bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure−Activity Relationship and Solubility Studies of N1‐Substituted Quinoxaline‐2,3‐diones as Kainate Receptor Antagonists
Authors: Chałupnik Paulina , Vialko Alina , Pickering Darryl S. , Nielsen Birgitte , Bay Yasmin , Skov Kristensen Anders , Hinkkanen Markus , Szczepańska Katarzyna , Karcz Tadeusz , Latacz Gniewomir , Johansen Tommy N. , Szymańska Ewa 
Published: June 2023

AbstractKainate receptors are a class of ionotropic glutamate receptors that respond to the excitatory neurotransmitter glutamate in the central nervous system and play an important role in the development of neurodegenerative disorders and the regulation of synaptic function. In the current study, we investigated the structure‐ activity relationship of the series of quinoxaline‐2,3‐diones substituted at N1, 6, and 7 positions, as ligands of kainate homomeric receptors GluK1‐3 and GluK5. Pharmacological characterization showed that all derivatives obtained exhibited micromolar affinity at GluK3 receptors with Ki values in the range 0.1–4.4 μM range. The antagonistic properties of the selected analogues: N‐(7‐fluoro‐6‐iodo‐2,3‐dioxo‐3,4‐dihydroquinoxalin‐1(2H)‐yl)‐3‐sulfamoylbenzamide, N‐(7‐(1H‐imidazol‐1‐yl)‐6‐iodo‐2,3‐dioxo‐3,4‐dihydroquinoxalin‐1(2H)‐yl)‐3‐sulfamoylbenzamide and N‐(7‐(1H‐imidazol‐1‐yl)‐2,3‐dioxo‐6‐(phenylethynyl)‐3,4‐dihydroquinoxalin‐1(2H)‐yl)‐3‐sulfamoylbenzamide at GluK3 receptors, were confirmed by an intracellular calcium imaging assay. To correlate in vitro affinity data with structural features of the synthesized compounds and to understand the impact of the substituent in N1 position on ability to form additional protein‐ligand interactions, molecular modeling and docking studies were carried out. Experimental solubility studies using UV spectroscopy detection have shown that 7‐imidazolyl‐6‐iodo analogues with a sulfamoylbenzamide moiety at the N1 position are the best soluble compounds in the series, with molar solubility in TRISS buffer at pH 9 more than 3‐fold higher compared to NBQX, a known AMPA/kainate antagonist.
An efficient fuzzy‐based task offloading in edge‐fog‐cloud architecture
Authors: Yadav Pratibha , Vidyarthi Deo Prakash 
Published: June 2023

AbstractIn a hierarchical edge‐fog‐cloud architecture, edge devices possess limited resources and energy. To contain with, it can offload some tasks generated by the Internet of Things (IoT) to the fog and cloud. Several factors influence this task‐offloading decision, including hardware features, network conditions, and application characteristics. Most of the research studies, in task offloading systems, have confined to changing parameter values, whereas very few have considered fuzzy‐based dynamic approaches for resource allocation. This work proposes a fuzzy‐based task offloading technique (FBOT) for scheduling the tasks (both compute and data‐intensive) to the appropriate nodes of the fog‐cloud system. The proposed method incorporates a vague logic‐based fuzzy task scheduler for scheduling various tasks at the fog layer. This helps to reduce the waiting time for the compute‐intensive tasks and minimizes the starvation problem of data‐intensive tasks. In addition, the proposed technique decreases the task completion time and selects the best computing nodes for each tasks. To validate the performance of the proposed technique, extensive simulation studies have been carried out on various parameters. Compared with the baseline algorithms, the results show that the proposed method offers an average improvement of 30% in terms of the total time of the task.
Examining an integrated sociocultural and objectification model of thinness‐ and muscularity‐oriented disordered eating in Chinese older men and women
Authors: Barnhart Wesley R. , Cui Tianxiang , Zhang Hengyue , Cui Shuqi , Zhao Yiqing , Lu Yining , He Jinbo 
Published: June 2023

AbstractObjectiveWe tested an integrated model of three prominent theories of disordered eating (tripartite influence theory, objectification theory, and social comparison theory) in a sample of older Chinese men and women.MethodChinese older men (n = 270) and women (n = 160) completed questionnaires assessing the tripartite influence, objectification, and social comparison theories and thinness‐ and muscularity‐oriented disordered eating. Two structural equation models were tested in Chinese older men and women.ResultsThe integrated model showed good model fit and described meaningful variance in thinness‐ and muscularity‐oriented disordered eating in Chinese older men and women. Higher appearance pressures were uniquely related to higher muscularity‐oriented disordered eating in men. Across both gender groups, higher thinness internalization was uniquely related to higher thinness‐ and muscularity‐oriented disordered eating, and in women only, higher muscularity internalization was uniquely related to lower thinness‐oriented disordered eating. In men, higher upward and downward body image comparisons were uniquely related to higher and lower, respectively, muscularity‐oriented disordered eating. In women, higher upward body image comparisons were only uniquely related to higher muscularity‐oriented disordered eating while higher downward body image comparisons were uniquely related to both outcomes. Higher body shame was uniquely related to higher thinness‐oriented disordered eating across both groups and in men alone, higher body shame was also uniquely related to higher muscularity‐oriented disordered eating.DiscussionFindings, which tested the integration of tripartite influence, objectification, and social comparison theories, inform the prevention and treatment of disordered eating in Chinese older populations.Public SignificanceThe present study is the first to describe theories of disordered eating (tripartite influence, objectification, and social comparison) in Chinese older adults. Findings suggested good model fit and the integrated models described meaningful variance in thinness‐ and muscularity‐oriented disordered eating in Chinese older women and men. Findings extend existing theories of disordered eating and, pending further study, may inform theory‐driven prevention and treatment approaches in Chinese older adults.
Serum TGF‐β as a predictive biomarker for severe disease and fatality of COVID‐19
Authors: Frischbutter Stefan , Durek Pawel , Witkowski Mario , Angermair Stefan , Treskatsch Sascha , Maurer Marcus , Radbruch Andreas , Mashreghi Mir‐Farzin 
Published: June 2023

AbstractFor targeted intervention in coronavirus disease 2019 (COVID‐19), there is a high medical need for biomarkers that predict disease progression and severity in the first days after symptom onset. This study assessed the utility of early transforming growth factor β (TGF‐β) serum levels in COVID‐19 patients to predict disease severity, fatality, and response to dexamethasone therapy. Patients with severe COVID‐19 had significantly higher TGF‐β levels (416 pg/mL) as compared to patients with mild (165 pg/mL, p < 0.0001) or moderate COVID‐19 (241 pg/mL; p < 0.0001). Receiver operating characteristics area under the curve values were 0.92 (95% confidence interval [CI] 0.85–0.99, cut‐off: 255 pg/mL) for mild versus severe COVID‐19, and 0.83 (95% CI 0.65–1.0, cut‐off: 202 pg/mL) for moderate versus severe COVID‐19. Patients who died of severe COVID‐19 had significantly higher TGF‐β levels (453 pg/mL) as compared to convalescent patients (344 pg/mL), and TGF‐β levels predicted fatality (area under the curve: 0.75, 95% CI 0.53–0.96). TGF‐β was significantly reduced in severely ill patients treated with dexamethasone (301 pg/mL) as compared to untreated patients (416 pg/mL; p < 0.05). Early TGF‐β serum levels in COVID‐19 patients predict, with high accuracy, disease severity, and fatality. In addition, TGF‐β serves as a specific biomarker to assess response to dexamethasone treatment.
Gold polycarbonate microchannels for electrochemical applications
Authors: Ogończyk D. , Jankowski P. 
Published: June 2023

AbstractIn this paper, we present gold‐plating polycarbonate (PC) microchannels. The fabrication of the gold microfluidic channels is achieved by tuning the sequence of reagent insertion into milled and closed submillimeter PC system channels. The resulting gold surface can be utilized in many applications where the benefits of microfluidics, (bio)chemistry of surfaces, and electrochemistry can be combined.Here, we combine the advantages of electrochemistry with microfluidics by mixing the gold sensor with microfluidics. This approach differs from the classic one – the sensor will undergo modifications (e. g., shape and size) depending on the specific scientific problem and will be designed individually; hence its characteristics will be changed. Our goal in this work is to indicate new possibilities for combining two methodologies – electrochemistry and microfluidics. In our work, we emphasize that it confirms the validity of our chosen concept (proof‐of‐concept).In this work, we present one such application, the use of a gold microfluidic channel as a working electrode (WE). We describe the microchip‘s construction and electrochemical characterization, including the gold flow‐through WE, the Ag/AgCl wire pseudo‐reference, and the Pt auxiliary electrode. The measured current is the result of the flow through a rectangular duct of the gold microchannel electrode embedded in the four walls of the chip.
Nickel oxyhydroxide/zinc hydroxide/rGO as a promising candidate for hybrid energy storage and clean energy generation
Authors: Baral Apurba , Bose Navonil , Show Bibhutibhushan , Bandyopadhyay Nil Ratan , Mukherjee Nillohit 
Published: June 2023

AbstractMetal hydroxides are the upcoming materials in the field of energy storage applications. In this work, a mixed metal hydroxide‐based carbon composite, that is, nickel oxyhydroxide/zinc hydroxide/rGO, was successfully synthesized through single step hydrothermal process. The synthesized material was thoroughly characterized using x‐ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy and field emission scanning electron microscopy. Detailed electrochemical analysis was performed through cyclic voltammetry, constant current charge‐discharge analysis and electrochemical impedance spectroscopy. The material exhibited impressive values of specific capacitance (541 F/g), energy density (75 Wh/kg) and power density (2592 W/kg). The electrodes were found to be sufficiently robust and reliable. A symmetric storage device was also fabricated using the synthesized composite followed by thorough electrochemical analyses of the same. A flexible piezoelectric nanogenerator was fabricated by impregnating the polymer PVDF with the synthesized composite that yielded an open circuit voltage of ~50 V and power density of 3117 W/m3. This opens up the possibilities of using the developed material in real life applications.
Deep learning on mixed frequency data
Authors: Xu Qifa , Wang Zezhou , Jiang Cuixia , Liu Yezheng 
Published: June 2023

AbstractIn deep learning, it is common to encounter data observed at different frequencies. Mixed data sampling (MIDAS) is an efficient technique for handling mixed frequency data, where a high frequency predictor is converted into a set of low frequency variables using the frequency alignment approach and parametric function constraints. This efficiently prevents the proliferation of parameters, ensuring the consistency of data frequency. We introduce the MIDAS technique into the deep learning architecture and develop a novel deep learning‐MIDAS (DL‐MIDAS) model, which enables to conduct deep learning on raw mixed frequency data directly. Its efficacy is then illustrated through extensive Monte Carlo simulations and a real‐world application. The simulation experiments show that the DL‐MIDAS model is able to explore nonlinear patterns in mixed frequency data and achieves more stable and accurate prediction results than several competing models, such as the artificial neural network for mixed frequency data (ANN‐MIDAS), long short‐term memory (LSTM), and MIDAS regressions. Additionally, the real‐world application of predicting the inflation rate of China also confirms the strength of DL‐MIDAS. The model can exploit high frequency information contained in financial market to produce timely and accurate prediction results on the inflation rate.
Thermotropic Colloidal Liquid‐Crystalline Hydroxyapatite Nanorod Hybrids Containing a Forklike Mesogen
Authors: Uchida Junya , Kiguchi Ryuta , Kato Riki , Kato Takashi 
Published: June 2023

AbstractWe here report the development of new thermotropic colloidal liquid‐crystalline (LC) organic/inorganic hybrids consisting of a hydroxyapatite (HAp)/poly(acrylic acid) (PAA) nanorod and a dendritic forklike mesogen. Complexation of the HAp/PAA nanorod covered with negatively charged PAA and a cationic forklike mesogen through electrostatic interactions and cation metathesis results in the surface modification of the HAp/PAA nanorod with the forklike mesogen. While the HAp/PAA nanorod forms a lyotropic colloidal LC phase in the aqueous dispersion, the HAp/PAA nanorod modified with the forklike mesogen exhibits thermotropic colloidal LC phases in the solvent‐free states. The biomineral‐based organic/inorganic colloidal liquid crystals exhibiting thermotropic LC properties have potential for the development of new stimuli‐responsive sustainable materials.
Gastrointestinal barrier integrity and mucosal inflammation as risk factors of blood stream infections in children treated for acute lymphoblastic leukaemia
Authors: De Pietri Silvia , Weischendorff Sarah , Rathe Mathias , Frandsen Thomas Leth , Hasle Henrik , Nersting Jacob , Nielsen Claus H. , Moser Claus , Müller Klaus 
Published: June 2023

AbstractChemotherapy‐induced mucositis increases the risk of blood stream infections (BSI) due to translocation of bacteria across the intestinal epithelium. Our study investigated if quantitative measures of intestinal mucositis severity, including plasma citrulline (a marker of functional enterocytes) and CCL20 (an intestinal immune homeostatic chemokine), could identify patients at risk of BSI. A total of 106 children with ALL undergoing induction treatment (NOPHO ALL 2008) were included and information regarding BSI episodes was collected from the patients' medical records. Twenty‐seven patients (25%) developed BSI during induction. Patients with BSI had a larger decrease in citrulline after chemotherapy than patients without BSI, and nearly all BSI episodes (25/27) occurred in the group of patients exhibiting a drop in citrulline (OR = 6.4 [95% CI: 1.4‐29.3], P = .008). Patients who developed BSI had higher plasma CCL20 levels on days 8, 15 and 22 than patients without BSI (all P < .05), and elevated CCL20 levels on day 8 increased the risk of subsequent BSI (OR = 1.57 [1.11‐2.22] per doubling of CCL20 level, P = .01) in a multivariable logistic regression analysis. These findings suggest that children with ALL who develop BSI during chemotherapy are characterised by more severe intestinal mucositis, as measured by plasma citrulline and CCL20. These markers may be useful in early risk stratification to guide treatment decisions.
Composite pheochromocytoma associated with neurofibromatosis type 1
Authors: Tachibana Akira , Iida Kota , Itami Yoshitaka , Hashimura Masaya , Hosokawa Yukinari , Fujimoto Kiyohide 
Published: June 2023

IntroductionComposite pheochromocytoma is a rare tumor, occurring in only 3% of pheochromocytomas. We report a case of composite pheochromocytoma with neurofibromatosis type 1.Case presentationA 42‐year‐old man was referred to our department for further evaluation of an incidentally detected right adrenal tumor. He was a patient at another hospital for neurofibromatosis type 1. The serum and urinary catecholamine levels exceeded the normal range. Abdominal computed tomography and magnetic resonance imaging showed a 2.8 cm diameter right adrenal tumor, and 123I‐metaiodobenzyguanidine scintigraphy showed radioisotope uptake. He was diagnosed with pheochromocytoma and underwent a right laparoscopic adrenalectomy. Histopathological examination revealed that the tumor consisted of a pheochromocytoma and ganglioneuroma. The final diagnosis was composite pheochromocytoma‐ganglioneuroma. Five years after surgery, no recurrence was observed.ConclusionPreoperative diagnosis of composite pheochromocytoma‐ganglioneuroma is difficult; therefore, histopathological examination is necessary for a definitive diagnosis. Pheochromocytoma management requires lifelong follow‐up.
Structure design and hydraulic performance analysis of drip emitters based on vortex energy dissipation
Authors: Wang Yue , Liu Ning‐ning , Wang Zhen‐hua , Tan Ming‐dong , Xu Xin , Xing Shao‐bo 
Published: June 2023

AbstractThe centre of the vortex within the drip irrigation emitter easily forms a low‐speed or zero‐velocity zone, which easily causes sediment deposition and blocks the narrow channel of the emitter. To solve this problem, a funnel‐shaped drip irrigation emitter was designed and optimized. Numerical simulations and field tests were conducted to compare and analyse the flow index, energy dissipation coefficient and relative energy dissipation ratio of the emitter. The results showed: (1) When the incident angle (θ) of the diversion channel increased from 0 to 37.4°, the energy dissipation increased from 20% to 64%. The main way of energy dissipation in the emitter changed from impingement of water to viscous drag in the vortex. (2) Under normal pressure, the energy dissipation coefficient of the vortex energy dissipation scheme (F5) was 60% higher than that of the impingement energy dissipation scheme (F1). The flow index of F5 was lower than that of F1 in both the high‐pressure and low‐pressure regions, which was in the range of 0.433–0.466. (3) Due to the spiral flow, there was a vortex with a large axial velocity inside the conical cavity, which can effectively avoid sediment deposition in the vortex centre.
Payment versus charitable donations to attract agricultural and natural resource survey participation
Authors: Penn Jerrod M. , Hu Wuyang 
Published: June 2023

AbstractThis analysis provides two case studies comparing direct payment versus charitable donations on respondents' behalf as survey participation incentives. The first examines agricultural producers' willingness to participate in several hypothetical surveys. Donation to charity significantly increases producers' willingness to participate relative to direct payment. The second case study examines forest landowners' willingness to participate in an actual, one‐time survey. Neither payment nor donation incentives improve participation among mail respondents and donations are less effective versus payment among online respondents. If they do not decrease participation, then donations may be preferred, requiring less effort to process a smaller number of transactions.
Identification of a Biallelic Missense Variant in Gasdermin D (c.823G > C, p.Asp275His) in a Patient of Atypical Gorham‐Stout Disease in a Consanguineous Family
Authors: Uehara Daniela Tiaki , Muramatsu Tomoki , Ishii Senichi , Suzuki Hidetsugu , Fukushima Kazuyuki , Arasaki Yasuhiro , Hayata Tadayoshi , Inazawa Johji , Ezura Yoichi 
Published: June 2023

ABSTRACTGorham–Stout disease (GSD), also called vanishing bone disease, is a rare osteolytic disease, frequently associated with lymphangiomatous tissue proliferation. The causative genetic background has not been noted except for a case with a somatic mutation in KRAS. However, in the present study, we encountered a case of GSD from a consanguineous family member. Whole‐exome sequencing (WES) analysis focusing on rare recessive variants with zero homozygotes in population databases identified a homozygous missense variant (c.823G > C, p.Asp275His) in gasdermin D (GSDMD) in the patient and heterozygous in his unaffected brother. Because this variant affects the Asp275 residue that is involved in proteolytic cleavage by caspase‐11 (as well as ‐4 and ‐5) to generate an activating p30 fragment required for pyroptotic cell death and proinflammation, we confirmed the absence of this cleavage product in peripheral monocytic fractions from the patient. A recent study indicated that a shorter p20 fragment, generated by further cleavage at Asp88, has a cell‐autonomous function to suppress the maturation of osteoclasts to resorb bone matrix. Thus, the present study suggests for the first time the existence of hereditary GSD cases or novel GSD‐like diseases caused by GSDMD deficiency. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
RETN gene polymorphisms interact with alcohol dependence in association with depression
Authors: Xu Xiaoyan , Xu Zeping , Zhou Fan , Chen Lijing , Li Huai , Niculescu Michelle , Shen Guanghui , Wu Liujun , Wang Wei , Chen Li , Liu Yanlong , He Jue , Wang Fan , Yang Fan 
Published: June 2023

AbstractBackgroundPrevious studies suggest that alcohol dependence is associated with increased risk of depression. The occurrence of depressive symptoms is related to polymorphisms in various genetic regions. This study aimed to investigate the interaction of RETN gene polymorphisms (rs1477341, rs3745368) with alcohol dependence on depressive symptoms in adult male during acute alcohol withdrawal.MethodsA total of 429 male adults were recruited in this study. Alcohol dependence was assessed using the Michigan alcoholism screening test (MAST). Depression was assessed using the 20‐item self‐rating depression scale (SDS). Hierarchical regression analysis was used to evaluate the interaction between genes and alcohol dependence on depression. Region of significance (ROS) test was used to explain the interaction effect. The strong and weak forms of the differential susceptibility and diathesis models were used to determine which fits the data better.ResultsOur results showed that MAST scores were significantly positively associated with SDS scores (r = 0.23, p < 0.01) in alcohol‐dependent patients during alcohol withdrawal. The interaction between genotype and alcohol dependence was significant (β = −0.14, p < 0.05) in a strong diathesis‐stress model. Susceptibility for depression symptoms was associated with alcohol dependence in RETN rs1477341 A carriers. Specifically, those that showed more alcohol dependence and the A allele of RETN rs1477341 exhibited more depression symptoms. However, RETN rs3745368 had no significant interaction with alcohol dependence.ConclusionsThe A allele of RETN rs1477341 may correlate with susceptibility to depression symptoms in alcohol‐dependent individuals during acute alcohol withdrawal.