bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between pain, nerve injury and clinical outcomes after flexor tendon injuries in zones 1-2: a retrospective cohort study
Authors: Beckmann-Fries Vera , Calcagni Maurizio , Schrepfer Lorena , Kaempfen Alexandre , Vögelin Esther , Tobler-Ammann Bernadette 
Published: March 2023

Introduction The influence of pain and a concomitant digital nerve injury on the course of rehabilitation after flexor tendon injury remains ambiguous. The objectives of the study were to: i) analyse the evolution of pain spanning one year after a primary flexor tendon repair in zones 1–3; ii) examine the differences in pain levels in patients with and without digital nerve injury; and iii) evaluate the relationship between pain, digital nerve injury and pain medication, total active motion (TAM), DASH scores and patient satisfaction. Methods Data from 189 patients were retrieved from a flexor tendon registry between 2014 and 2020. Differences in pain, TAM, DASH and patient satisfaction were analysed. Multiple linear and binary logistic regression analyses were performed to determine the relationship between clinical outcomes. Results Pain significantly decreased in the course of rehabilitation ( p < 0.001 to 0.006). No relationship could be identified between nerve injury and pain ( p = 0.21–0.97). In week 6, the presence of pain and a nerve injury were significantly associated with lower TAM scores ( p = 0.001). In week 13, pain during motion ( p < 0.001) and the presence of a nerve injury ( p = 0.036) were significantly associated with worse DASH scores. Patient satisfaction was significantly inversely correlated to pain during motion in weeks 13 and 26 ( p < 0.001). Conclusion We found a significant relationship between pain during motion and pain medication intake, TAM, DASH scores and patient satisfaction. It is therefore advisable to closely monitor this parameter after flexor tendon injuries. Study registration This multi-center cohort study is registered under https://clinicaltrials.gov : NCT04312412 .
Prevalence of Imaging Detected Silent Male Breast Cancer in Autopsy Specimens: Study of the Disease Held by Image-Guided Biopsies
Authors: Sidiropoulou Zacharoula , Vasconcelos Ana Paula , Couceiro Cristiana , Santos Carlos Dos , Araújo Ana Virginia , Alegre Inês , Santos Claudia , Costa Filipa , Cardoso Diogo , Cardoso Vasco , Sampaio Rita , Cardoso Fátima , Gascon Pere 
Published: March 2023

Introduction: Regarding male breast cancer, a rare disease comprising ∼1% of breast cancers, data are generally scant. The present study aimed to quantify the imaging detected breast cancer in male gender corpses, determining in this way the prevalence of silent breast cancer in male gender. Methodology: The population target has been male corpses without clinical expression of breast cancer. Seventy-four male corpses have been submitted to bilateral subcutaneous radical mastectomy. Samples have been submitted to echography and mammography imaging and every lesion superior to BI-RADS 4a has been excised. Results: One excisional biopsy has been performed and no case of breast cancer has been identified. Discussion: Our findings suggest that screening of the general population for male breast cancer is not necessary.
The Longer-Term Effects of a Single Bupivacaine Exposure on the Mechanical Properties of Native Cartilage Explants
Authors: Callan Kylie T. , Otarola Gaston , Brown Wendy E. , Athanasiou Kyriacos A. , Wang Dean 
Published: March 2023

Objective The purpose of this study was to determine the in vitro effects of a single exposure of bupivacaine on the mechanical properties of bovine cartilage explants at 3 weeks. Design Femoral condyle articular cartilage explants were aseptically harvested from juvenile bovine stifle joints before being exposed to chondrogenic medium containing 0.50% (wt/vol) bupivacaine, 0.25% (wt/vol) bupivacaine, or no medication (control) for 1 hour. Explants were then washed and maintained in culture in vitro for 3 weeks before testing. Cell viability, tensile and compressive mechanical properties, histological properties, and biochemical properties were then assessed. Results Explants exhibited a dose-dependent decrease in mean tensile Young’s modulus with increasing bupivacaine concentration (9.86 MPa in the controls, 6.48 MPa in the 0.25% bupivacaine group [ P = 0.048], and 4.72 MPa in the 0.50% bupivacaine group [ P = 0.005]). Consistent with these results, collagen content and collagen crosslinking decreased with bupivacaine exposure as measured by mass spectrometry. Compressive properties of the explants were unaffected by bupivacaine exposure. Explants also exhibited a trend toward dose-dependent decreases in viability (51.2% for the controls, 47.3% for the 0.25% bupivacaine-exposed group, and 37.0% for the 0.50% bupivacaine-exposed group [ P = 0.072]). Conclusions Three weeks after 1-hour bupivacaine exposure, the tensile properties of bovine cartilage explants were significantly decreased, while the compressive properties remained unaffected. These decreases in tensile properties corresponded with reductions in collagen content and crosslinking of collagen fibers. Physicians should be judicious regarding the intra-articular administration of bupivacaine in native joints.
Bilateral contracture of the carpal and digital flexor muscles resulting in carpal flexural deformity in a cat
Authors: Vrijsen Emily , Hamon Martin , Picavet Pierre , Bouvy Bernard , Balligand Marc 
Published: March 2023

Case summary A 12-year-old neutered female domestic shorthair cat was presented with bilateral progressive forelimb lameness that was unresponsive to anti-inflammatory drugs. Bilateral carpal flexural deformity with hyperflexion of multiple toes of the right forelimb was observed. In the absence of abnormalities detected on radiographs and ultrasound, a bilateral contracture of the carpal and digital flexor muscles was diagnosed. Treatment consisted of single-session bilateral selective tenectomies (5 mm) of the flexor carpi ulnaris, flexor carpi radialis and superficial digital flexor muscle tendons on the left forelimb and tendons of the flexor carpi ulnaris muscle, and branches of the third and fourth digit of the deep digital flexor muscle on the right forelimb. Two months postoperatively, selective tenectomies (10 mm) were performed due to contracture recurrence on the left forelimb. The subjective outcome was rated as good 6 months postoperatively. Relevance and novel information Digital and/or carpal contractures are rarely described in (feline) veterinary medicine and are limited to a few case reports. The exact aetiology remains unknown. A traumatic/iatrogenic origin seems to be the most likely cause. Surgery is indicated, consisting of selective tenectomy and/or tenotomy, and is associated with minor complications and an excellent outcome. This case report describes the presence, treatment and successful outcome of a cat with bilateral carpal and digital flexor muscle contractures resulting in carpal flexural deformity with valgus deviation treated with selective tenectomies.
Assessing Appropriateness for Shoulder Arthroplasty Using a Shared Decision-Making Process
Authors: Razmjou Helen , Christakis Monique , Nam Diane , Drosdowech Darren , Sheth Ujash , Wainwright Amy , Richards Robin 
Published: March 2023

Purpose The primary purpose of this study was to validate an appropriateness decision-aid tool as a part of engaging patients with glenohumeral arthritis in their surgical management. The associations between the final decision to have surgery and patient characteristics were examined. Materials and Methods This was an observational study. The demographics, overall health, patient-specific risk profile, expectations, and health-related quality of life were documented. Visual analog scale and the American Shoulder & Elbow Surgeon (ASES) measured pain and functional disability, respectively. Clinical and imaging examination documented clinical findings and extent of degenerative arthritis and cuff tear arthropathy. Appropriateness for arthroplasty surgery was documented by a 5-item Likert response survey and the final decision was documented as ready, not-ready, and would like to further discuss. Results Eighty patients, 38 women (47.5%), mean age: 72(8) participated in the study. The appropriateness decision aid showed excellent discriminate validity (area under the receiver operating characteristic curve value of 0.93) in differentiating between patients who were “ready” and those who were “not-ready” to have surgery. Gender ( P  =  0.037), overall health ( P  =  .024), strength in external rotation ( P  =  .002), pain severity ( P  =  .001), ASES score ( P < .0001), and expectations ( P  =  .024) were contributing factors to the decision to have surgery. Imaging findings did not play a significant role in the final decision to have surgery. Conclusions A 5-item tool showed excellent validity in differentiating patients who were ready to have surgery versus those who were not. Patient's gender, expectations, strength, and self-reported outcomes were important factors in reaching the final decision.
Are Prospective Criteria or Objective Clinical Measures Utilized in Return to Play (RTP) Decision Making After Ankle Surgery? A Scoping Review
Authors: Wright Cynthia J. , Robinson Anastasia B. J. , Waldrop Norman E. , Anderson Robert B. , Clanton Thomas O. 
Published: March 2023

Background: Manuscripts discussing return to play (RTP) following ankle surgery are common. However, the definition for RTP and the method by which it is determined remains unclear. The purpose of this scoping review was to clarify how RTP is defined following ankle surgery in physically active patients, to identify key factors informing RTP decision making (such as objective clinical measures), and make recommendations for future research. Methods: A scoping literature review was performed in April 2021 using PubMed, EMBASE, and Nursing and Allied Health databases. Thirty studies met inclusion criteria: original research following ankle surgery reporting at least 1 objective clinical test and documentation of RTP. Data were extracted for study methods and outcomes (RTP definition, RTP outcomes, and objective clinical tests). Results: The scoping review found studies on 5 ankle pathologies: Achilles tendon rupture, chronic lateral ankle instability, anterior ankle impingement, peroneal tendon dislocation, and ankle fracture. RTP criteria were not provided in the majority of studies (18/30 studies). In the studies that provided them, the RTP criteria were primarily based on time postsurgery (8/12) rather than validated criteria. Objective clinical outcome measures and patient-reported outcome measures (PROMs) were documented for each surgery when available. Both clinical outcomes and PROMs were typically measured >1 year postsurgery. Conclusion: In physically active patients who have had ankle surgery, RTP remains largely undefined and is not consistently based on prospective objective criteria nor PROMS. We recommend standardization of RTP terminology, adoption of prospective criteria for both clinical measures and PROMs to guide RTP decision making, and enhanced reporting of patient data at the time of RTP to develop normative values and determine when the decision to RTP is not safe. Level of Evidence: Level IV, scoping review.
The Lasting Impact of Generational Mentors: Drs. Joseph G. McCarthy and Henry K. Kawamoto
Authors: Clappier Mona , Choe Joshua , Barnett Sarah , Miller Meghan , Bradley James P. 
Published: March 2023

Background: Within the field of plastic and craniofacial surgery, Joseph G. McCarthy, M.D. and Henry K. Kawamoto Jr., M.D., D.D.S. have both dedicated a significant portion of their career, time, and effort to mentoring the next generation of surgeons. Our study reflects the impact of these generational mentors by analyzing the career paths and academic contributions of their graduate plastic and craniofacial surgeon mentees. It also highlights the unique mentorship styles of Drs. McCarthy and Kawamoto. Methods: Academic productivity of trainees under Drs. Kawamoto and McCarthy who completed a craniofacial fellowship (n = 81) or plastic surgery residency (n = 270) from 1984 to 2016 were assessed using institutional records. Curriculum vitae, practice websites, and personal correspondence were used to record practice type, geographic location, academic titles, societal leadership roles, mission trip involvement, and bibliometric data (publications, citations, h-index, grants). Results: The craniofacial fellows studied had a mean time since completion of fellowship training of 21 ± 11 years. Three-fourths had active craniofacial practices (75.3%) and over half of the fellows continued to practice in an academic setting (56.8%). The majority continued their surgical practice in the United States with a distribution of 24.7% in the Northeast, 29.6% in the South, 11.1% in the Midwest, and 25.9% in the West. Many became Division/Department Chiefs (42.0%), Craniofacial Directors (45.7%) and professional societal leaders (49.4%). Many sustained research productivity with an average of 77 ± 136 publications; 2070 ± 5459 citations; and h-index of 17 ± 16. An additional analysis of plastic surgery residents showed almost as robust of an academic interest: 34.5% were appointed Chief; 52 ± 95 mean publications; 1808 ± 4517 citations; and h-index of 15 ± 15. These numbers superseded other plastic surgery graduates. Conclusions: The McCarthy and Kawamoto craniofacial fellows and plastic surgery residents were noted to have impressive academic records. Mentorship relationships should be envisioned as a 2-way “Give-Get” relationship that will improve clinical skills, research productivity, and patient care.
Feminizing Genioplasty: A Review of Operative Techniques and Clinical Outcomes
Authors: Khetpal Sumun , Baker Nusaiba F. , Hu Vivian , Dejam Dillon , Patel Harsh , Morgan Katarina B. J. , Wolfe Erin M. , Lee Justine C. 
Published: March 2023

Background: Facial feminization procedures can be performed to alleviate gender dysphoria among transfeminine or non-binary patients. Moreover, the chin may play an important role in immediate identification and recognition of the face as cis-masculine or cisfeminine, and thus, can be addressed via feminizing genioplasty in the transfeminine population. The purpose of this study was multi-fold: 1) perform a systematic literature review to investigate the current methods utilized to feminize the chin, and 2) study clinical outcomes within an institutional cohort undergoing feminizing genioplasty. Methods: A systematic literature review was conducted in order to survey articles that discussed techniques and clinical considerations when performing genioplasty among transgender females and nonbinary patients. In addition, a retrospective review of such patients undergoing genioplasty by the senior author was conducted. Variables collected included demographic factors, operative details, and postoperative outcomes. Results: Query of the PubMed database resulted in forty articles after removal of duplicates. Eleven studies that discussed surgical technique about genioplasty in facial feminization surgery were selected for analysis and discussion. Commonly discussed techniques were surgical incision, horizontal and vertical reduction, and material used for fixation. Eighty-seven patients were included in our institutional cohort. Approximately half of the patients underwent 2-piece reduction genioplasty, while 8 patients had 1-piece reduction. Horizontal osteotomies and vertical osteotomies were performed in the majority of patients. About one-third of patients received osseous augmentation via centralized osteotomy segments and cranial bone grafts. Conclusions: The core tenets of feminization of the chin lie in the reduction in both horizontal and vertical planes, as well as the creation of harmony with other facial structures. Our analysis presents an updated review of these principles, as well as an in-depth analysis of the senior author’s technique in feminization of the chin in transgender women.
Plastic behaviour of clay materials for the manufacture of fast-drying red ceramics
Authors: Nandi Vitor de Souza , Zaccaron Alexandre , Raupp-Pereira Fabiano , Arcaro Sabrina , Bernardin Adriano Michael , Montedo Oscar Rubem Klegues 
Published: March 2023

AbstractFast drying (~60 min) is useful for optimizing production processes by increasing productivity and reducing costs and environmental impacts, especially in red ceramic industries in Brazil. However, suitable clays are necessary and, currently, studies focused on the plastic behaviour of clays with compositions suitable for extrusion, especially for fast drying, are scarce. Therefore, in this study, three different clays from the same mineral deposit were studied for producing clay-based structural products via fast drying. The clays were characterized according to their chemical, mineralogical and thermal properties, particle size, cation-exchange capacity, specific surface area and open pore volume distribution. Ten formulations were developed using a simplex-centroid mixture design of experiments and their plasticity index (PI) values were determined. The response surfaces of the formulations were evaluated according to their PI, while the formation characteristics were determined according to their extrusion workability factor values. Formulations F5 (50.0 wt.% yellow clay and 50.0 wt.% green clay) and F8 (66.6 wt.% yellow clay, 16.7 wt.% grey clay and 16.7 wt.% green clay; PI = 15.5–16.6%) displayed optimal extrusion properties, followed by formulations F7 (33.3 wt.% yellow clay, 33.3 wt.% grey clay and 33.3 wt.% green clay) and F10 (16.7 wt.% yellow clay, 16.7 wt.% grey clay and 66.6 wt.% green clay; PI = 13.8–14.2%), which are within acceptable extrusion index values. Thus, the chosen formulations have significant potential for use in the manufacture of fast-drying red ceramics.
Longitudinal patient-reported outcomes in patients receiving chimeric antigen receptor T-cell therapy
Authors: Johnson P. Connor , Dhawale Tejaswini , Newcomb Richard A. , Amonoo Hermioni L. , Lavoie Mitchell W. , Vaughn Dagny , Karpinski Kyle , El-Jawahri Areej 
Published: March 2023

Abstract
Chimeric antigen receptor T-cell therapy (CAR-T) has transformed the treatment for relapsed/refractory hematologic malignancies; however, data on patient-reported outcomes in CAR-T are limited. We conducted a longitudinal study of adults with hematologic malignancies receiving CAR-T. We assessed quality of life (QOL; functional assessment of cancer therapy–general), psychological distress (hospital anxiety and depression scale, patient health questionnaire-9, posttraumatic stress disorder [PTSD] checklist), and physical symptoms (Edmonton symptom assessment scale–revised) at baseline, 1 week, 1, 3, and 6 months after CAR-T. We used linear mixed models to identify factors associated with QOL trajectory. We enrolled 103 of 142 eligible patients (3 did not receive CAR-T). QOL (B = 1.96; P &lt; .001) and depression (B = −0.32; P = .001) worsened by 1 week and improved by 6 months after CAR-T. At 6 months, 18%, 22%, and 22% reported clinically significant depression, anxiety, and PTSD symptoms, respectively. At 1 week, 52% reported severe physical symptoms, declining to 28% at 6 months after CAR-T. In unadjusted linear mixed models, worse Eastern Cooperative Oncology Group performance status (B = 1.24; P = .042), receipt of tocilizumab (B = 1.54; P = .042), and receipt of corticosteroids for cytokine release syndrome and/or neurotoxicity (B = 2.05; P = .006) were associated with higher QOL trajectory. After CAR-T, QOL declined, and depression increased early, followed by improvements in QOL, psychological distress, and physical symptoms by 6 months after infusion. A significant minority of patients reported substantial psychological distress and physical symptoms longitudinally.
Erythroferrone exacerbates iron overload and ineffective extramedullary erythropoiesis in a mouse model of β-thalassemia
Authors: Olivera Joseph , Zhang Vida , Nemeth Elizabeta , Ganz Tomas 
Published: March 2023

Abstract
β-thalassemia is characterized by chronic hepcidin suppression and iron overload, even in patients who have not undergone transfusion. The HbbTh3/+ (Th3/+) mouse model of nontransfusion–dependent β-thalassemia (NTDBT) partially recapitulates the human phenotype but lacks chronic hepcidin suppression, progressive iron accumulation into adulthood, or the interindividual variation of the rate of iron loading observed in patients. Erythroferrone (ERFE) is an erythroid regulator that suppresses hepcidin during increased erythropoiesis. ERFE concentrations in the sera of patients with NTDBT correlate negatively with hepcidin levels but vary over a broad range, possibly explaining the variability of iron overload in patients. To analyze the effect of high ERFE concentrations on hepcidin and iron overload in NTDBT, we crossed Th3/+ mice with erythroid ERFE–overexpressing transgenic mice. Th3/ERFE-transgenic mice suffered high perinatal mortality, but embryos at E18.5 showed similar viability, appearance, and anemia effects as Th3/+ mice. Compared with Th3/+ littermates, adult Th3/ERFE mice had similarly severe anemia but manifested greater suppression of serum hepcidin and increased iron accumulation in the liver, kidney, and spleen. The Th3/ERFE mice had much higher concentrations of serum ERFE than either parental strain, a finding attributable to both a higher number of erythroblasts and higher production of ERFE by each erythroblast.Th3/+ and Th3/ERFE mice had similar red blood cell count and shortened erythrocyte lifespan, but Th3/ERFE mice had an increased number of erythroid precursors in their larger spleens, indicative of aggravated ineffective extramedullary erythropoiesis. Thus, high ERFE concentrations increase the severity of nontransfusional iron overload and ineffective erythropoiesis in thalassemic mice but do not substantially affect anemia or hemolysis.