bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glutamine defended the kidneys versus lead intoxication via elevating endogenous antioxidants, reducing inflammation and carbonyl stress as well as improving insulin resistance and dyslipidemia
Authors: Mahdavifard Sina Mahdavifard. , Najafzadeh Newruz 
Published: July 2023

Abstract
Objective(s):
Kidneys are primarily sensitive to lead (Pb) poisoning due to their cardinal role in lead excretion. Then, we studied the effect of glutamine (Gln) on lead nephrotoxicity in rats by assessing the histopathological and biochemical parameters (the renal NF-kβ expression, metabolic profile, oxidative stress, inflammatory markers, methylglyoxal (MGO), and glyoxalase-I activity).
Materials and Methods
Forty rats were allotted into four groups (ten rats in each): normal (N), Gln treated N, Pb intoxication (Pbi), and Gln treated Pbi. The treated groups took 0.1% Gln in drinking water for one month. To motivate lead poisoning, rats gained 50 mg/l lead acetate in drinking water for one month. Oxidative stress indices (total glutathione, its reduced and oxidized forms, and their ratios as well as advanced protein oxidation products, malondialdehyde, and ferric ion reducing power) and inflammatory markers (renal nuclear factor-kβ expression, interleukin 1β level, and myeloperoxidase activity) were measured. Further, metabolic profile (fasting blood sugar, insulin, insulin sensitivity, lipid profile, and atherogenic index) and renal dysfunction parameters were also determined. Pb-induced renal damage and dysfunction were assessed with Histopathological examination.
Results
In the kidney of Pbi rats, the glomerulus was damaged. Gln prevented kidney damage and reduced kidney dysfunction parameters. In addition, Gln decreased oxidative stress and inflammation in sera and kidney homogenates as well as improved insulin resistance, dyslipidemia, and carbonyl stress (p < 0.001).
Trypanosoma cruzi amastigote transcriptome analysis reveals heterogenous populations with replicating and dormant parasites
Authors: Desale Hans , Herrera Claudia , Dumonteil Eric 
Published: July 2023

Abstract
Trypanosoma cruzi is a protozoan parasite causing Chagas disease, with a complex life cycle involving different stages in insect vectors and mammalian hosts. Amastigotes are an intracellular form that replicates in the cytoplasm of host cells, and recent studies suggested that dormant forms may be contributing to parasite persistence, suggesting cellular heterogeneity among amastigotes. We investigated here if a transcriptomic approach could identify some heterogeneity in intracellular amastigotes and identify a dormant population. We used gene expression data derived from bulk RNA-sequencing of T. cruzi infection of human fibrobasts for deconvolution using CDSeq, which allows to simultaneously estimate amastigote cell-type proportions and cell-type-specific expression profiles. Six amastigote subpopulations were identified, confirming intracellular amastigotes heterogeneity, and one population presented characteristics of non-replicative dormant parasites, based on replication markers and TcRAD51 expression. Transcriptomic approaches appear to be powerful to understand T. cruzi cell differentiation and expansion of these studies could provide further insight on the role different cell types in parasite persistence and Chagas disease pathogenesis.
Screening of potential phytocompounds against Atherosclerosis by directing Liver X Receptor alpha (LXRα): A computational manoeuvre
Authors: Lokhande Kiran Bharat , Pawar Sarika Vishnu , Nawani Neelu , Wani Minal , Swamy K. Venkateswara , Ghosh Payel , Kale Arti Abhijit 
Published: July 2023

Abstract
Liver X receptor alpha (LXRα) is a nuclear receptor family member that is expressed in the liver, and has gained pharmacological interest for its role in the reduction of atherosclerosis, a long-term inflammatory disorder that affects the artery wall and is characterized by alterations in lipid metabolism. LXRα activators appear to be promising targets for preventing and/or treating these pathological conditions. The current work intends to perform a computational analysis of the IMPPAT database with LXRα. This comprehensive study will serve as a foundation for the investigation of novel plant-derived LXRα agonists against atherosclerosis. LXRα (PDB ID: 3IPU) was used as a target molecule for docking analysis. The docking scores of top five phytocompounds from the IMPAAT database, namely Betaxanthin, Adlumidiceine, Miraxanthin III S, Lupinisoflavone E, and p-Coumaroyl triacetic acid, ranged from - 35.88 kcal/mol to - 32.46 kcal/mol. The docking analysis was validated further by a 100 ns molecular dynamics study, which revealed fewer fluctuations in RMSD along with stable intermolecular interactions of lead phytocompounds with the targeted LXRα protein. The enrichment calculation metrics also validated the efficiency of the docking procedure. As evidenced by the MM-GBSA study, the binding free energies (ΔGbind) score up to -71.219 kcal/mol, with no violations in terms of drug likeliness and ADMET predictions, indicated the promising nature of these phytocompounds as drug candidates against atherosclerosis. These in silico studies, in particular, aid in analyzing phytocompounds roles as potential lead drugs, paving the way for in vitro and in vivo assessments for the development of novel anti-atherosclerosis drugs.
Growth of diamond in liquid metal at 1 atmosphere pressure
Authors: Gong Yan , Luo Da , Choe Myeonggi , Seong Won Kyung , Bakharev Pavel , Wang Meihui , Lee Seulyi , Shin Tae Joo , Lee Zonghoon , Ruoff Rodney S. 
Published: July 2023

Abstract
Natural diamonds were (and are) formed (some, billions of years ago) in the Earth’s upper mantle in metallic melts in a temperature range of 900–1400°C and at pressures of 5–6 GPa1,2; indeed, diamond is thermodynamically stable under high pressure and high temperature (HPHT) conditions as per the phase diagram of carbon3. Scientists at General Electric invented and used a HPHT apparatus in 1955 to synthesize diamonds from melted iron sulfide at about 7 GPa and 1600°C4–6. There is an existing paradigm that diamond can be grown using liquid metals only at both high pressure (typically 5–6 GPa) and high temperature (typically 1300–1600°C) where it is the stable form of carbon7. Here, we describe the growth of diamond crystals and polycrystalline diamond films with no seed particles using liquid metal but at 1 atmosphere pressure, and at 1025°C, breaking this paradigm. Diamond grew at the interface of liquid metal composed of gallium, iron, nickel, and silicon and a graphite crucible, by catalytic activation of methane and diffusion of carbon atoms in the subsurface region of the liquid metal. Raman spectroscopy with 13C-labeling proves that methane introduced into the growth chamber is the carbon source for many of the regions of newly grown diamond. The new growth diamonds were studied by Raman spectroscopy, scanning and transmission electron microscopy, X-ray diffraction, and photoluminescence. Growth of (metastable) diamond in liquid metal at moderate temperature and 1 atm pressure opens many possibilities for further basic science studies and for the scaling of this type of growth.
Inherent Characterstics of Recycled Concrete Aggregate by Limited Substitution of Cement With Ashes Like GGBS and Fly Ash Powder
Authors: vvs sarma , shaik subhan alisha , Pala Gireesh kumar , Sampangi Arun Chaitanya , thumati venkateswararao 
Published: July 2023

Abstract
The current study aims to estimate the strength performance of recycled aggregate concrete (RAC) applied in structural concrete by partially substituting cement with fly ash and ground granulated blast furnace slag (GGBS). The purpose of this project is to get a deeper understanding of the characteristics of RAC using GGBS and fly ash as additional cement materials. Concrete specimens containing various ratios of recycled coarse aggregate, fly ash, and GGBS are casted as part of our experiment. Analysis and comparison of the outcomes with the reference concrete mixture are performed. The results of this study will help advance sustainable concrete technology and serve as a foundation for designing RAC for structural applications that incorporates recycled coarse aggregate, fly ash, and GGBS. In our study we conducted tests like Compressive strength of concrete, split tensile strength of the concrete, Flexural strength of the concrete, recycled aggregate used partially in our study is 20%, 40%,60% and GGBS powder used partially in cement with percentages of 10,15,20 and parlay with fly ash content partially used in cement with percentages of 10,15,20. Our observation from this project is we good acceptable values combinedly at the percentages of 40% Recycled aggregate and 15 percentages of both GGBS and FA .We can have further research work by implementing the same research with wide verity range of cement materials.
Analysis of the curative effect and risk factors for recurrence of modified Sistrunk procedure on thyroglossal duct cyst in children
Authors: Zhang Ge , Li Xiaodan , Hao Jinsheng , Zhang Jie , Li Yanzhen , Zhang Xuexi , Liu Qiao , Sun Nian , Liu Zhiyong , Chen Ziwei , Liu Yuwei , Ji Tingting , Pang Wei , Wang Shengcai , Ni Xin 
Published: July 2023

Abstract
Objectives
The present study aimed to retrospectively summarize the optimization experience of the modified Sistrunk (mSis) procedure, analyze the curative efficacy of this procedure in the treatment of children with thyroglossal duct cyst (TGDC), and investigate the related risk factors for recurrence.
Methods
A retrospective analysis was conducted on children undergoing mSis procedure from March 2012–December 2021. Based on our practical experience, the mSis procedure has been optimized in the following details: the resection at the cartilaginous joint of hyoid bone, core out to the foramen cecum, and the resection and ligation techniques of the fistula near the foramen cecum. Medical history, physical examination characteristics, ultrasound characteristics, and prognosis were evaluated by regression analysis.
Results
Of the 391 children with TGDC, the recurrence rate was 2.30% and the recurrence time ranged from 0.5–34 (average, 7.2) months after the procedure. During the follow-up, 10 children had local wound infection but no recurrence and none had other complications. In the Poisson regression model, the p-values of the three factors of clearness of lesion boundary, surgical history, and lesion diameter were < 0.05 and the relative risk (RR) values corresponding to the above three risk factors, such as Exp (B), were 27.918, 10.054, and 6.606, respectively.
Conclusion
The present study made optimizations based on the previous mSis procedure and integrated the complete resection and less injury. Thus, the procedure was safe and effective with fewer complications and a low recurrence rate. In addition, the indistinct lesion boundary, surgical history, and large lesion diameter were independent risk factors for disease recurrence.
Level of Evidence: IV
Likely Hydrolysis of Phoenix dactylifera Cell Wall Pectin by Fusarium oxysporum Pectin Methylesterase and Endo-polygalacturonase Activity Revealed in Vitro
Authors: Cherif Brahim , Karkachi Noureddine , Yezli Wassim , Henni Jamal Eddine , Kihal Mebrouk 
Published: July 2023

Abstract
Fusarium oxysporum forma specialis albedinis is the causal agent of Phoenix dactylifera vascular fusariosis. It hydrolyzes the pectocellulosic wall of Phoenix dactylifera vascular tissue. Pectinases hydrolyze cell wall pectin, but they are not active in all strains, so it is not clear whether such hydrolysis is a mechanism of pathogenesis. This research tries to answer this question by testing the significance of pectin methylesterase and endo-polygalacturonase activity in hydrolyzing P. dactylifera cell wall pectin and suggests their mechanism of pathogenesis. Six F. oxysporum strains isolated from P. dactylifera of Beni Abbes and Ghardaia provinces were grown in glucose and in pectin, and the enzyme activity was measured with titrimetric methods. The activity in all strains was quantified and then compared with growth carbohydrates and provinces with statistical tests. We found that pectin methylesterase from both growth conditions hydrolyzed pectin, but endo-polygalacturonase was not active in glucose. Surprisingly, statistical tests showed that this inhibition was not caused by carbon catabolite repression. Pectin methylesterase was more active than endo-polygalacturonase in pectin and in strains isolated from P. dactylifera of Beni Abbes. We suggest that F. oxysporum inhibits endo-polygalacturonase, using an unknown mechanism. We conclude that the product of hydrolysis gradually blocks sap circulation and causes maceration of the rachis. We revealed that F. oxysporumhas a significant pectin methylesterase and endo-polygalacturonase activity, which can hydrolyze the cell wall pectin of P. dactylifera. Themaceration of date palms may be caused by these enzymes, and endo-polygalacturonase inhibition is not directly caused by glucose.
Intravascular large B-cell lymphoma (IVLBCL): Subtle Presentation and Challenging Diagnosis
Authors: Bendari Ahmed 
Published: July 2023

Abstract
Intravascular large B-cell lymphoma (IVLBCL) is a rare, clinically aggressive lymphoma defined by the proliferation of atypical lymphoma cells in the lumen of all sized blood vessels, particularly capillaries. The reasons for this unusual neoplastic cell proliferation are still only partially understood. IVLBCL is considered stage IV lymphoma and manifests with a variety of nonspecific signs and symptoms. Patients with IVBCL usually do not present with lymphadenopathy. The tumor cells invade the blood vessels of multiple organs such as the central nervous system, skin, lungs, kidneys, and bone marrow. Common presenting symptoms are based on the organ affected and include mental status changes and fever of unknown origin. Although immunochemotherapy has significantly improved the often-poor prognosis of this kind of lymphoma, a large percentage of patient’s relapse.
We present a 63-year-old man who had been diagnosed with high grade B cell lymphoma in the bone marrow in March 2021 and was in remission state after completing six cycles of chemotherapy. There was no abnormal FDG uptake on a post-chemotherapy PET/CT scan. Patient presented to the ER 1 year later with fever and dyspnea. The entire workup was completed and showed pancytopenia and elevated ESR. PET/CT scans revealed a widespread increase in FDG uptake in both the lungs and spleen. Lung biopsy revealed large, atypical cells only within alveolar septae and vessels that were positive for CD20 and PAX-5 and had high proliferation rate based on Ki67. The diagnosis of IVLBCL was made.
IVLBCL has a low incidence rate with non-specific clinical presentation. The diagnosis can be easily missed in both clinical, radiological and the corresponding histopathological findings. Radiological finding and CT scan are not sensitive enough and may miss the lesion. Even though the PET/CT scan is more sensitive, the definitive diagnosis of IVLBCL relies mainly on histopathology and immunohistochemistry, at which point awareness and high suspicious of this entity by the pathologist is most necessary.
Videolecciones: el toque humano en una virtualidad instalada
Authors: Martinez Canto Eugenio , Baccelli Sandra , Distéfano María Laura 
Published: July 2023

Este artículo explora el impacto del uso de materiales audiovisuales en los procesos de enseñanza y aprendizaje, particularmente en la asignatura Análisis Matemático A de las carreras de Ingeniería, en la Universidad Nacional de Mar del Plata (Argentina). Se presentan las distintas etapas en el diseño, elaboración e implementación de diversos recursos. Los contenidos abordados a través de estos materiales corresponden a Curvas Planas. Como parte del proceso de uso de estos materiales se implementó la modalidad conocida como Aula Invertida, donde la actividad del estudiante tiene lugar antes y durante la clase presencial. El marco teórico utilizado para analizar los aspectos didácticos es el Enfoque Ontosemiótico. La evaluación de estos materiales y de su impacto se efectuó a través de encuestas a docentes y estudiantes. Estos últimos valoraron positivamente estos recursos y mostraron preferencia por aquellos videos con la presencia visible de un profesor explicando en lugar de presentaciones de PowerPoint con voz en off. Se extendió la implementación de este tipo de materiales hacia otros contenidos de la asignatura. De esta manera, se favorece tanto la participación activa del estudiante en su proceso de aprendizaje como un acercamiento a las preferencias de una generación nativa digital.
Delineation of groundwater potential zones and identification of artificial recharge sites in the Kinnerasani Watershed, India, using remote sensing-GIS, AHP, and Fuzzy-AHP techniques
Authors: Shekar Padala Raja , Mathew Aneesh 
Published: July 2023

Abstract

The sustainable management of groundwater resources is crucial for ecological diversity, human health, and economic growth. This study employs scientific concepts and advanced techniques, including the analytic hierarchy process (AHP) and Fuzzy-AHP, to identify groundwater potential zones (GWPZs). Thematic maps representing drainage density, elevation, soil, geomorphology, slope, land use and land cover, and rainfall are used to delineate the GWPZs. Both techniques are employed to assign weights to these thematic maps based on their characteristics and water potential. The study revealed that in the investigated area, 17.76 and 18.27% of the final GWPZs (AHP and Fuzzy-AHP) can be classified as having poor potential, while 72.79 and 71.07% are categorized as having moderate potential. Moreover, 9.45 and 10.69% of the final GWPZs are identified as having high potential using the AHP and Fuzzy-AHP models, respectively. Receiver operating characteristics (ROCs) analysis is employed to validate these findings, demonstrating that the Fuzzy-AHP technique achieves an accuracy of 74% in identifying GWPZs in the region. This study utilizes the best method derived from both models to identify 26 suitable locations for artificial recharge sites. The reliable findings of this research offer valuable insights into decision-makers and water users in the Kinnerasani Watershed.
Simultaneous immobilization of heavy metals and nutrient elements in contaminated sediment using a novel composite agent product
Authors: Fu Xiaori , Huo Peishu , Wang Wenji , Li Dexiao , Liu Xiaojing , Zeng Guilu , Lyu Shuguang 
Published: July 2023

Abstract

In this research, an innovative type of sediment resource treatment agent (SRA) was synthesized successfully, which could immobilize ammonia nitrogen (NH3-N), total phosphorus (TP), potassium (K), and simultaneously stabilize cadmium (Cd), lead (Pb), chromium (Cr), copper (Cu), nickel (Ni), and zinc (Zn) in dredged sediment. The effects of SRA dosage on stabilizing the nutrient elements and heavy metals were investigated. The results demonstrated that the increase of SRA dosage significantly enhanced the stabilization of nutrients and heavy metals. The 14-day rainwater infiltration and rainwater scouring experiments were carried out. With the simulation test of rainwater infiltration, the stabilization ratios of Cr, Cu, Ni, Pb, Zn, Cd, NH3-N, TP, and K with 2% SRA addition reached 80.8%, 76.8%, 80.3%, 77.5%, 78.0%, 72.7%, 64.3%, 73.9%, and 73.9%, respectively. Under the action of rainwater scouring, the stabilization ratios of Cr, Cu, Ni, Pb, Zn, Cd, NH3-N, TP, and K with 6.4% SRA addition reached 84.6%, 84.0%, 77.6%, 87.3%, 80.0%, 61.5%, 76.2%, 77.8%, and 91.7%, respectively. Therefore, the results demonstrate that SRA is an excellent composite material in stabilizing heavy metals while reserving the nutrients in dredged sediment, thus showing great potential in the application for dredged sediment resource treatment.
Level of disclosure in sustainability reports in accordance with the Global Reporting Initiative (GRI)
Authors: Três Pamela , Domenico Daniela Di , Três Naline 
Published: July 2023

Objective: Analyze the level of disclosure in sustainability reports in accordance with the Global Reporting Initiative (GRI), through a descriptive study, with document analysis and a quantitative procedure.
Methodology: The research population comprised all companies listed on B3 that published sustainability reports through their respective websites, in the years 2015 to 2020, the sample being composed of 103 companies.
Results: The study points out that the group of organizational profile indicators presented the highest average of disclosure with 96.34%. From another perspective, the groups of items related to market presence, safety practices, indigenous peoples' rights and marketing and labeling had the lowest disclosure rate, 26.10%. It is conclude that as there is greater complexity in the items related to indicators of sustainability reports in accordance with the GRI model, the level of disclosure by companies is reduced. Thus, the complexity of the information of certain items is related to the probability of non-disclosure.
Contributions of the study: Therefore, in this study, all indicators of greater and lesser complexity were analyzed, highlighting that as there is greater complexity and effort on the part of companies in the items related to indicators of sustainability reports in accordance with the GRI model, the a lower level of disclosure by companies. In this way, the complexity of the information of certain items is related to the probability of non-disclosure.
Influence of using the budget and heuristic biases on the professional competencies of bean counters and business partners
Authors: Wohlemberg Tiago Ramos , Villalba Veronica Ahimaras , Dal Vesco Delci Grapegia , Toigo Leandro Augusto 
Published: July 2023

Objective: The objective of this research is to verify if the use of diagnostic or interactive budgets, moderated by heuristic behaviors, influences the controllers' professional competencies.
Methodology: This is a descriptive research study carried out by means of a survey with 109 individuals who work as controllers. In order to meet the research objective, in addition to diagnosing the data by counting the answers, a logistic regression model was used, chosen by means of the Wald Backward Stepwise method.
Results: The results found in the research indicate that there is predominance of competencies linked to the bean counter profile in the controllers' work functions. Regarding use of the budget, it was found that using the interactive budget to communicate goals to their work teams is characteristic of controllers whose professional competencies belong to the business partner profile and present behaviors influenced by heuristics and who, regardless of such influence, use the interactive budget for discussion of actions; whereas use of the diagnostic budget for managerial planning is characteristic of bean counters. It was also found that heuristic components are present in the controllers' behaviors, especially those of Anchoring and Availability, although it was not possible to directly link them to these individuals' professional competencies.
Contributions of the study: The theoretical contributions of the study clarify the relationship between the specific uses of diagnostic or interactive budgets influenced by heuristic behaviors and the controllers' professional competencies. The research expands the debate on the controller's role that prevails in Brazil.