bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Sostac's Digital Marketing Planning Strategy on Marketing Performance Through Competitive Advantage
Authors: Suharyati Suharyati , Handayani Tati , Nobelson Nobelson 
Published: July 2023

The majority of MSMEs in the Sukmajaya sub-district, Depok, are engaged in the culinary field, totaling 771 MSMEs out of a total of 2,835 MSMEs. The decline in the number of MSMEs in 2020 due to the Covid-19 pandemic has made it difficult for MSMEs to market their products. On the other hand, during this period, SMEs emerged with digital innovation. Digital marketing planning is necessary for MSMEs in running their business to create a competitive advantage and improve marketing performance. MSMEs that do not implement digital marketing in running their business will be left behind and lose customers because customer buying behavior has changed towards digital.
This research is quantitative descriptive research using the SmartPLS 3.0 tool to analyze the effect of each variable. The type of data is primary data by distributing questionnaires to 125 Culinary MSME respondents in the Sukmajaya sub-district, Depok city via Google form. In this study, data analysis techniques were carried out in the form of descriptive data analysis and inferential data analysis, and hypothesis testing.
The results of the study prove that digital marketing planning using the SOSTAC method has a positive and significant effect on Competitive advantage, SOSTAC Digital marketing planning has a positive and significant effect on marketing performance and Competitive advantage has a positive and significant effect on marketing performance. The results of the study show that SOSTAC Digital Marketing Planning has a positive and significant indirect relationship to marketing performance through competitive advantage, which is bigger than the direct relationship. Thus, in SOSTAC Digital Marketing Planning, to achieve marketing performance, MSME actors must first be able to create a competitive advantage.
2006-2017 Yılları Arasında İnşa Edilen Post-Modern Hükümet Konakları
Authors: TOPTAŞ Rahşan 
Published: July 2023

Öz
Çalışmamızda 2006-2012 yılları arasında inşa edilen hükümet konakları ele alınmıştır. Hükümet konaklarının Osmanlı İmparatorluğu’ndan günümüze kadar Türk mimarlık tarihi çerçevesinde geçirdiği değişim ve gelişim ele alınarak tümevarım yöntemi ile günümüzdeki durum ortaya konulmaya çalışılmıştır. İç İşleri Bakanlığı verileri ana kaynak olarak kabul edilmiştir. 260 adet konağın bu boyutta bir çalışma için detaylı incelemesinin mümkün olmaması nedeni ile genel, tarihi, cephe özellikleri ve tipolojileri üzerinde toplu olarak durulmuştur. Konakların mimarlık dönemleri içerisinde meydana gelen üslup değişimlerinden etkilendiği görülmüştür. 2006-2017 tarihleri arasında inşa edilen konakların özellikle Osmanlı Geç Dönem ve I. Ulusal Mimarlık Dönemi kamu binalarından plan, cephe ve üslup bakımından etkilendiği görülmüştür. Ele alınan dönemin hükümet konakları açısından postmodern bir yaklaşımla inşa edildikleri düşünülmektedir.
Overconsolidated Stress and Strain Condition of Pavement Layers as a Result of Preloading during Construction
Authors: Vámos Máté János , Szendefy János 
Published: July 2023

The stiffness and resilient behavior of soils are essential input properties when designing pavements. There are many material models that take into account the stress dependency of stiffness. In pavements, horizontal stresses generally differ from conventional soils because of the preloading of the pavement during construction. In this research, standardized pavement cross sections were analyzed using finite element software with advanced soil constitutive models, and equations describing their behavior were calibrated with the back-analysis of in-situ and laboratory measurements. The pavement was modelled as comprising 4 layers: asphalt pavement, well graded crushed stone base course, granular subbase course and fine-medium sandy subgrade. The ratio of horizontal and vertical stresses σ3/σ1 and strains ε3/ε1 were investigated and assessed in the function of depth and loading, and recommendations are given for the description of these functions. The recommendations give useful input data for future practical applications such as simplified calculation methods that are capable of determining the permanent settlement beneath flexible pavements without the use of finite element methods.
Influence of probiotic supplementation on the growth performance, plasma variables, and ruminal bacterial community of growth-retarded lamb
Authors: Mao Huiling , Ji Wenwen , Yun Yan , Zhang Yanfang , Li Zhefeng , Wang Chong 
Published: July 2023

IntroductionGrowth-retarded lambs would reduce the economic incomes of sheep farming. Nutritional interventions are supposed to promote gastrointestinal health and the compensatory growth of growth-retarded lambs. This study evaluated the effects of probiotic supplementation on the growth performance, plasma characteristics and ruminal bacterial community of growth-retarded lambs.MethodsTwenty-four 50-days old male Hu lambs, including 8 healthy lambs (13.2 ± 1.17 kg) and 16 growth-retarded lambs (9.46 ± 0.81 kg), were used in this study. The 8 healthy lambs were fed the basal diet and considered the positive control (GN), and the other 16 growth-retarded lambs were randomly assigned into 2 groups (basal diet without probiotic [negative control, GR] and basal diet supplementation with 1 g/kg concentrate feed probiotic [GRP]), with each group having 4 replicate pens. The feeding trial lasted for 60 days with 7 days for adaptation.ResultsThe results showed that dietary supplementation with probiotic increased (p &lt; 0.05) the average daily gain and dry matter intake of growth-retarded lambs. For growth-retarded lambs, supplementation with probiotic increased (p &lt; 0.05) the activities of superoxide dismutase and glutathione peroxidase, as well as the concentrations of growth hormone and immunoglobulin G. Furthermore, the highest (p &lt; 0.05) concentrations of interleukin-6, interferon-gamma and tumor necrosis factor alpha were observed in the GR group. The concentrations of total volatile fatty acids and acetate in growth-retarded lambs were increased by probiotic supplementation (p &lt; 0.05). The relative abundances of Ruminococcus, Succiniclasticum and Acidaminococcus were lower (p &lt; 0.05) in growth-retarded lambs. However, probiotic supplementation increased (p &lt; 0.05) the relative abundances of these three genera.DiscussionThese results indicate that dietary supplementation with probiotic are promising strategies for improving the growth performance of growth-retarded lambs by enhancing immunity and altering the ruminal microbiota.
Molecular epidemiology, risk factors, and outcomes of carbapenem-resistant Klebsiella pneumoniae infection in a tertiary hospital in eastern China: for a retrospective study conducted over 4 years
Authors: Cheng Jun , Zhao Dongmei , Ma Xuejiao , Li Jiabin 
Published: July 2023

ObjectivesCarbapenem-resistant Klebsiella pneumoniae (CRKP) have been extensively disseminated worldwide, resulting in increased mortality. We performed a retrospective analysis of the epidemiology and risk factors for the outcome of CRKP infection in a general teaching hospital in China.MethodsA molecular and clinical study was conducted for 98 CRKP in a tertiary hospital from January 2013 to December 2016. Carbapenemase gene detection, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST) were performed. Logistic regression was also used to identify the risk factors associated with 30-day mortality.ResultsThe production of KPC carbapenemase was the main resistant mechanism, and KPC carbapenemase increased annually with a significant difference. However, the molecular outcome revealed the dominance and diversity in CRKP with 24 sequence types (STs) and 59 PFGE types (PTs). The ST11 CRKP strains, which showed a significant increasing trend year by year, were documented as predominant in our study. Additionally, the predominant ST11 CRKP corresponding to PT10 and PT15 continued to exhibit their characteristic patterns. Importantly, the newly identified PT09 and PT16 strains, corresponding to the ST11 lineage, were only discovered in 2016. Meanwhile, factors affecting 30-day mortality and ST11 proportionality with CRKP infection were assessed, and ST11, appropriate empirical treatment, and hospital stays were found to be independently associated with 30-day mortality.ConclusionThe ST11 CRKP strains played a dominant role in the process; however, the homology of these strains was polymorphic, and the advantage clusters were subject to changes through evolution. Furthermore, in addition to appropriate empirical treatment and hospital stays, ST11 CRKP was independently associated with 30-day mortality. To the best of our knowledge, this association was reported for the first time.
Identification of a novel CNV at the APC gene in a Chinese family with familial adenomatous polyposis
Authors: Li Juyi , He Chengzhi , Gong Jing , Wang Xiufang , Liu Chao , Deng Aiping , Zhu Lin 
Published: July 2023

Introduction: Familial adenomatous polyposis (FAP) is the second most commonly inherited colorectal cancer (CRC) predisposition caused by germline mutations within the adenomatous polyposis coli (APC) gene. The molecular defects and clinical manifestations of two FAP families were analyzed, and individual prevention strategies suitable for mutation carriers in different families were proposed.Methods and results: The pathogenic gene mutations were identified among the two families using whole-exome sequencing and verified with Sanger sequencing or quantitative polymerase chain reaction (qPCR). One novel (GRCh37:Chr5: 112145676–112174368, del, 28,692 bp) and a known (c.C847T:p.R283X) mutation in the APC gene were pathogenic mutations for FAP, according to the sequencing data and tumorigenesis pattern among the family members. The two mutations led to a premature translational stop signal, synthesizing an absent or disrupted protein product.Conclusion: Our findings expand the known germline mutation spectrum of the APC gene among the Chinese population. This reaffirms the importance of genetic testing in FAP. Genetic consultation and regular follow-ups are necessary for the individualized treatment of cancer-afflicted families with APC expression deficiency. Additional work is required to develop safe and effective chemotherapy and immunotherapy for FAP based on the mutation type.
Pregnancy after kidney transplantation: an observational study on maternal, graft and offspring outcomes in view of current literature
Authors: Stavart Louis , Verly Camille , Venetz Jean-Pierre , Baud David , Legardeur Helene , Vial Yvan , Golshayan Dela 
Published: July 2023

IntroductionPregnancy after kidney transplantation (KTx) is considered to have a high risk of non-negligible complications for the mother, the allograft, and the offspring. With an increased incidence of these pregnancies over the past decades, transplant nephrologists and specialized obstetricians face increasing challenges, with scarce literature regarding long-term outcomes.MethodsWe retrospectively collected data from all women with at least one live birth pregnancy after KTx who were followed at our tertiary hospital between 2000 and 2021 to study maternal, graft and fetal outcomes.ResultsTen patients underwent 14 live birth pregnancies after KTx. Preponderant maternal complications were stage 1 acute kidney injury (43%), urinary tract infections (UTI, 43%), progression of proteinuria without diagnostic criteria for preeclampsia (29%), and preeclampsia (14%). Median baseline serum creatinine at conception was 126.5 µmol/L [median estimated glomerular filtration rate (eGFR) 49 mL/min/1.73m2], and eGFR tended to be lower than baseline at follow-ups. Overall, there was no increase in preexisting or occurrence of de novo donor-specific antibodies. No graft loss was documented within the 2-year follow-up. There were nine premature births (64%), with a median gestational age of 35.7 weeks. The median birth weight, height, and head circumference were 2,560 g, 45.5 cm, and 32.1 cm, respectively. These measurements tended to improve over time, reaching a higher percentile than at birth, especially in terms of height, but on average remained under the 50th percentile curve.DiscussionOverall, pregnancies after KTx came with a range of risks for the mother, with a high prevalence of cesarean sections, emergency deliveries, UTI, and preeclampsia, and for the child, with a high proportion of prematurity, lower measurements at birth, and a tendency to stay under the 50th percentile in growth charts. The short- and long-term impact on the allograft seemed reassuring; however, there was a trend toward lower eGFR after pregnancy. With these data, we emphasize the need for a careful examination of individual risks via specialized pre-conception consultations and regular monitoring by a transplant nephrologist and a specialist in maternal–fetal medicine during pregnancy. More data about the long-term development of children are required to fully apprehend the impact of KTx on offspring.
Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice
Authors: Wang Jing , Lu Yujiao , Carr Christopher , Dhandapani Krishnan M. , Brann Darrell W. 
Published: July 2023

IntroductionChronic neuroinflammation can exist for months to years following traumatic brain injury (TBI), although the underlying mechanisms remain poorly understood.MethodsIn the current study, we used a controlled cortical impact mouse model of TBI to examine whether proinflammatory senescent cells are present in the brain long-term (months) after TBI and whether ablation of these cells via administration of senolytic drugs can improve long-term functional outcome after TBI. The results revealed that astrocytes and microglia in the cerebral cortex, hippocampus, corpus callosum and lateral posterior thalamus colocalized the senescent cell markers, p16Ink4a or p21Cip1/Waf1 at 5 weeks post injury (5wpi) and 4 months post injury (4mpi) in a controlled cortical impact (CCI) model. Intermittent administration of the senolytic drugs, dasatinib and quercetin (D + Q) beginning 1-month after TBI for 13 weeks significantly ablated p16Ink4a-positive- and p21Cip1/Waf1-positive-cells in the brain of TBI animals, and significantly reduced expression of the major senescence-associated secretory phenotype (SASP) pro-inflammatory factors, interleukin-1β and interleukin-6. Senolytic treatment also significantly attenuated neurodegeneration and enhanced neuron number at 18 weeks after TBI in the ipsilateral cortex, hippocampus, and lateral posterior thalamus. Behavioral testing at 18 weeks after TBI further revealed that senolytic therapy significantly rescued defects in spatial reference memory and recognition memory, as well as depression-like behavior in TBI mice.DiscussionTaken as a whole, these findings indicate there is robust and widespread induction of senescent cells in the brain long-term after TBI, and that senolytic drug treatment begun 1-month after TBI can efficiently ablate the senescent cells, reduce expression of proinflammatory SASP factors, reduce neurodegeneration, and rescue defects in reference memory, recognition memory, and depressive behavior.
Efficacy of opioids for traumatic pain in the emergency department: a systematic review and Bayesian network meta-analysis
Authors: Fu Yawen , Liu Qiang , Nie Hu 
Published: July 2023

Aim: To systematically assess and rank the efficacy of opioid medications for traumatic pain in the emergency department in terms of pain relief, adverse events and rescue analgesia.Methods: Four databases were systematically searched until 26 September 2022: PubMed, Embase, Cochrane Library, and Web of Science. Outcomes were pain relief, adverse events (dizziness, hypotension, pruritus, sedation), and rescue analgesia. For each outcome, network plots were drawn to exhibit direct and indirect comparisons, and rank probabilities were utilized to rank the efficacy of different opioids.Results: Twenty studies of 3,040 patients were eligible for this network meta-analysis. According to the rank probabilities, the top three analgesic medications for pain relief may be sufentanil (78.29% probability of ranking first), buprenorphine (48.54% probability of ranking second) and fentanyl (53.25% probability of ranking third); buprenorphine (31.20%), fentanyl (20.14%) and sufentanil (21.55%) were least likely to cause dizziness; the top three analgesic medications which were least likely to cause hypotension were buprenorphine (81.64%), morphine (45.02%) and sufentanil (17.27%); butorphanol (40.56%), morphine (41.11%) and fentanyl (14.63%) were least likely to cause pruritus; the top three medications which were least likely to cause sedation were hydrocodone + acetaminophen (97.92%), morphine (61.85%) and butorphanol (55.24%); patients who received oxycodone (83.64%), butorphanol (38.31%) and fentanyl (25.91%) were least likely to need rescue analgesia in sequence.Conclusion: Sufentanil, buprenorphine and fentanyl may be superior to other opioid medications in terms of pain relief and the incidence of dizziness, hypotension and pruritus, which might be selected as opioid analgesics for traumatic pain in the emergency setting.
Effects of pre-anthesis low-temperature stress on the mineral components in wheat grains
Authors: Ji Wenbin , Hu Xinyi , Kang Meng , Qiu Xiaolei , Liu Bing , Tang Liang , Zhu Yan , Cao Weixing , Liu Leilei 
Published: July 2023

IntroductionThe nutritional value of wheat is important to human health. Despite minerals being essential nutrients for the human body, they are often neglected in consideration of the nutritional quality of cereal grains. Extreme low-temperature events have become more frequent due to the current environmental unpredictability, and it is yet unknown how the mineral components in grains are affected by low temperature.MethodsTo provide valuable information for enhancing the nutritional quality of wheat under potential climatic conditions, we treated different cold-sensitive wheat cultivars at four low-temperature levels during the individual and combined stages of jointing and booting in controlled-environment phytotrons. Results and DiscussionIn general, the contents of P, K, Ca, and Zn in the cold-sensitive cultivar (Yangmai16) and K in the cold-tolerant cultivar (Xumai30) were enhanced by low temperature. However, the accumulation of minerals in mature grains was reduced under low-temperature treatment, except for P, Ca, and Zn in Yangmai16. In addition, the mineral content and accumulation in Yangmai16 (except for Fe) were more susceptible to low temperature during the combined stages, while the mineral content and accumulation of K, Fe, and Zn in Xumai30 were more susceptible to low temperature during the booting stage. Moreover, Yangmai16 under extremely low temperatures (T3 and T4) during booting and Xumai30 under all low-temperature treatments during the combined stages had lower comprehensive evaluation values. These findings offer a crucial reference for enhancing the nutritional quality of wheat grains under climate change.
Improving collegiate student-athletes’ well-being: exploring the roles of openness to experience, knowledge sharing and perceived coaching effectiveness
Authors: Ni Peihao , Feng Ligang 
Published: July 2023

IntroductionCollegiate student-athletes often encounter various stressors stemming from academic study and athletic training, which can potentially have negative effects on their well-being. This study investigates how collegiate student-athletes’ openness to experience and their engagement in knowledge sharing influence their well-being, as well as the moderating role of perceived coaching effectiveness.MethodsTo examine these relationships, we propose and test a conceptual framework using an online survey conducted among collegiate student-athletes from a southeastern province of China. The participants consisted of 484 collegiate student-athletes who voluntarily participated in the study. We used regression analysis and mediation analysis to test the proposed relationships among the variables.ResultsOpenness to experience has a positive impact on knowledge sharing (β = 0.552, p &lt; 0.05); knowledge sharing with peers positively affects collegiate student-athlete well-being (β = 0.415, p &lt; 0.05) and mediates the relationship between openness to experience and collegiate student-athlete well-being (β = 0.086, p &lt; 0.05). Perceived coaching effectiveness positively moderates the relationship between openness to experience and knowledge sharing (β = 0.170, p &lt; 0.05).DiscussionOur study contributes to the collegiate student-athlete literature by shedding light on the factors that influence their well-being, with insights that bear important managerial implications for universities and coaches.
Psychiatric manifestations of Kleefstra syndrome: a case report
Authors: Yoshida Kazunari , Müller Daniel J. , Desarkar Pushpal 
Published: July 2023

BackgroundKleefstra syndrome is a rare genetic condition, which affects at least 1 in 120,000 individuals who have a neurodevelopmental disorder, characterized by the core clinical phenotype of intellectual disability, hypotonia, severe speech delay, and distinct facial characteristics with additional clinical features including sleep disturbance, overweight, psychiatric disorders, and autism spectrum disorder. To date, a limited number of case reports of Kleefstra syndrome with psychiatric manifestations have been reported.Case presentationWe reported a case of a 35-year-old male diagnosed with Kleefstra syndrome, who also had diagnoses of autism spectrum disorder and moderate to severe intellectual disability. He exhibited various psychiatric manifestations, including temporarily manic-like symptoms, excessive eating/overweight, addictive/gambling behaviors, inappropriate and unsafe internet use, sleep disturbance, rigid routines, and behaviors that challenged in the form of meltdowns. These symptoms were eventually relatively successfully managed with a combination of non-pharmacological and pharmacological treatments.ConclusionTo our knowledge, there is only a limited number of case reports that detail patients with Kleefstra syndrome exhibiting various psychiatric manifestations. Our report adds further knowledge to the paucity of literature and highlights the effectiveness of a combination of non-pharmacological and pharmacological treatments for behavioral/psychiatric difficulties in Kleefstra syndrome.