bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Humidity‐Enhanced Adhesion of Geckos: Deep Neural Network‐Assisted Multi‐Scale Molecular Modeling
Authors: Materzok Tobias , Eslami Hossein , Gorb Stanislav N. , Müller‐Plathe Florian 
Published: January 2023

AbstractA higher relative humidity leads to an increased sticking power of gecko feet to surfaces. The molecular mechanism responsible for this increase, however, is not clear. Capillary forces, water mediating keratin‐surface contacts and water‐induced softening of the keratin are proposed as candidates. In previous work, strong evidence for water mediation is found but indirect effects via increased flexibility are not completely ruled out. This article studies the latter hypothesis by a bottom‐up coarse‐grained mesoscale model of an entire gecko spatula designed without explicit water particles, so that capillary action and water‐mediation are excluded. The elasticity of this model is adjusted with a deep neural network to atomistic elastic constants, including water at different concentrations. Our results show clearly that on nanoscopic flat surfaces, the softening of keratin by water uptake cannot nearly account for the experimentally observed increase in gecko sticking power. Here, the dominant mechanism is the mediation of keratin‐surface contacts by intervening water molecules. This mechanism remains important on nanostructured surfaces. Here, however, a water‐induced increase of the keratin flexibility may enable the spatula to follow surface features smaller than itself and thereby increase the number of contacts with the surface. This leads to an appreciable but not dominant contribution to the humidity‐increased adhesion. Recently, by atomistic grand‐canonical molecular dynamics simulation, the room‐temperature isotherm is obtained for the sorption of water into gecko keratin, to the authors’ knowledge, the first such relation for any beta‐keratin. In this work, it relates the equilibrium water content of the keratin to the ambient relative humidity.
Fast Living 3D Printing via Free Radical Promoted Cationic RAFT Polymerization
Authors: Zhao Bowen , Li Jiajia , Li Guangliang , Yang Xinrui , Lu Shaopu , Pan Xiangqiang , Zhu Jian 
Published: January 2023

AbstractThe application of reversible deactivation radical polymerization techniques in 3D printing is emerging as a powerful method to build “living” polymer networks, which can be easily postmodified with various functionalities. However, the building speed of these systems is still limited compared to commercial systems. Herein, a digital light processing (DLP)‐based 3D printing system via photoinduced free radical‐promoted cationic reversible addition‐fragmentation chain transfer polymerization of vinyl ethers, which can build “living” objects by a commercial DLP 3D printer at a relatively fast building speed (12.99 cm h−1), is reported. The polymerization behavior and printing conditions are studied in detail. The livingness of the printed objects is demonstrated by spatially controlled postmodification with a fluorescent monomer.
Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example
Authors: Meng Qi , Ding Binbin , Ma Ping'an , Lin Jun 
Published: January 2023

AbstractProgrammed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) and immunogenic cell death (ICD), as important cell death mechanisms, are widely reported in cancer therapy, and understanding the relationship between the two is significant for clinical tumor treatments. Considering that vast nanodrugs are developed to induce tumor PCD and ICD simultaneously, in this review, the interrelationship between PCD and ICD is described using nanomedicines as examples. First, an overview of PCD patterns and focus on the morphological differences and interconnections among them are provided. Then the interrelationship between apoptosis and ICD in terms of endoplasmic reticulum stress is described by introducing various cancer treatments and the recent developments of nanomedicines with inducible immunogenicity. Next, the crosstalk between non‐apoptotic (including necrosis, ferroptosis, pyroptosis, and autophagy) signaling pathways and ICD is introduced and their relationship through various nanomedicines as examples is further illustrated. Finally, the relationship between PCD and ICD and its application prospects in the development of new ICD nanomaterials are summarized. This review is believed to deepen the understanding of the relationship between PCD and ICD, extend the biomedical applications of various nanodrugs, and promote the progress of clinical tumor therapy.
Anion Storage of MXenes
Authors: Wang Guanyao , Park Jae Min , Kang Taehun , Lee Sang Joon , Park Ho Seok 
Published: January 2023

AbstractRecently, anion storage materials have gained significant attention owing to the widened cell voltage and additional anion storing capacity for a large energy density. MXenes are considered as the emerging anion storing materials owing to their sufficient interlayer spacing, rich surface chemistries, tunable structures, remarkable electrochemical properties, and mechanical integrity. Herein, a comprehensive review on the anion storage of MXenes covering their anion storage mechanism and state‐of‐the‐art chemical strategies for the improved anion storage performances is reported. The recent progress of MXenes on aluminum ion batteries, metal halogen batteries, halogen ion batteries, and electrochemical electrode deionization is addressed. The scientific and technical challenges and the research direction into the anion storage of MXenes are also addressed and finally the authors’ perspective on anion storage of MXenes is provided. Therefore, this review offers an insight into the rational design of MXenes for anion storage materials and the correlation of surface chemistries and structural modifications with anion storage properties for the applications into electrochemical energy storage and water purification.
An efficient in‐gel digestion method on small amounts of protein sample from large intact gel pieces
Authors: Kano Keiko , Noda Saki , Sato Shinya , Kuwata Keiko , Mishiro‐Sato Emi 
Published: January 2023

AbstractIn‐gel digestion is an essential method, but there has been concern that a large ratio of gel volume to protein volume will reduce digestion efficiency and make it difficult to recover peptides after digestion. Few methods for handling large gel pieces have been established. Therefore, we optimized the in‐gel digestion method to handle large intact gel pieces containing small amounts of proteins.As a model for large intact gel pieces containing small amounts of protein, gel pieces of 7 × 10 mm in size obtained by short‐range sodium dodecyl‐sulfate polyacrylamide gel electrophoresis of 150 ng of total protein extracted from Arabidopsis cells were used. The use of a positive pressure manifold and 96‐well filter enabled rapid and uniform liquid exchange and gel drying, even when handling multiple gel pieces, and reduced the labor required for a liquid exchange. This facilitated the study of conditions using multiple gels and enabled a detailed study of the enzyme solution permeation and elution methods. By using the optimized method, we were able to establish a method for recovering small amounts of protein from large intact gel pieces without compromising reproducibility or recovery rate.
Resistant Starch as a Novel Carrier for Delivery of Probiotics Exploring Effectiveness of Two Different Strategies of Encapsulation
Authors: Gani Adil , Akther Gazalla , Ashwar Bilal Ahmad , Jhan Faiza , Shah Asima 
Published: January 2023

AbstractIn the present study, three probiotic strains viz. Bifidobacterim bifidum, Lactobacillus casei, and Lactobacillus plantarum were encapsulated in resistant starch derived from Indian horse chestnut (HRS) and rice (RRS) by using freeze drying and emulsification techniques. Encapsulation yield for probiotics was found to be in the range of 71.9%–73.3% and 70.2.2%–73.4% using emulsification and freeze drying techniques. ATR‐FTIR spectral analysis of all the microcapsules reveals peaks in the range of 1332–1371 cm−1 and 2910–2925 cm−1 confirming the presence of encapsulated probiotics. Scanning electron microscopy (SEM) shows granules with size ranging from 4 to 25 µm having different shapes. Cells encapsulated via emulsification show significantly better survivability during storage for a period of 3 months. Moreover, the survival rate of all the three microencapsulated probiotic cells remains comparably better under simulated gastrointestinal conditions than the free cells with minimal difference between the two techniques of encapsulation.
Exploring Links Between Aural Lexical Knowledge and L2 Listening in Arabic and Japanese Speakers: A Close Replication of Cheng, Matthews, Lange and McLean (2022)
Authors: Matthews Joshua , Masrai Ahmed , Lange Kriss , McLean Stuart , Alghamdi Emad A. , Kim Young Ae , Shinhara Yukie , Tada Saori 
Published: January 2023

AbstractAural lexical knowledge (ALK) is crucial for second language (L2) listening. Despite its importance, there is scant research that has validly explored the relationship between ALK and L2 listening across different English as a Foreign Language (EFL) contexts. In an effort to broaden this research base, the current study closely replicates a previous study, Cheng et al. (2022), which measured single‐word ALK, phrasal verb ALK and L2 listening comprehension among participants with Chinese as a first language (L1). The current study administered the same instruments but did so among 147 Japanese and 131 Arabic‐speaking English language learners. Results indicated that the capacity of ALK to predict variance in L2 listening for the Japanese group (R2 = .38) was similar to that observed in the original study (R2 = .42). However, the results for the Arabic‐speaking group were very different to that of the original study and showed an unexpectedly strong relationship between ALK and L2 listening (R2 = .92). Future research directions and pedagogical implications are discussed.
Higher-spin self-dual Yang-Mills and gravity from the twistor space
Authors: Herfray Yannick , Krasnov Kirill , Skvortsov Evgeny 
Published: January 2023

Abstract
We lift the recently proposed theories of higher-spin self-dual Yang-Mills (SDYM) and gravity (SDGR) to the twistor space. We find that the most natural room for their twistor formulation is not in the projective, but in the full twistor space, which is the total space of the spinor bundle over the 4-dimensional manifold. In the case of higher-spin extension of the SDYM we prove an analogue of the Ward theorem, and show that there is a one-to-one correspondence between the solutions of the field equations and holomorphic vector bundles over the twistor space. In the case of the higher-spin extension of SDGR we show show that there is a one-to-one correspondence between solutions of the field equations and Ehresmann connections on the twistor space whose horizontal distributions are Poisson, and whose curvature is decomposable. These data then define an almost complex structure on the twistor space that is integrable.
Representation Varieties of Twisted Hopf Links
Authors: González-Prieto Ángel , Muñoz Vicente 
Published: January 2023

AbstractIn this paper, we study the representation theory of the fundamental group of the complement of a Hopf link with n twists. A general framework is described to analyze the $${{\,\textrm{SL}\,}}_r({\mathbb {C}})$$

SL

r

(
C
)

-representation varieties of these twisted Hopf links as byproduct of a combinatorial problem and equivariant Hodge theory. As application, close formulas of their E-polynomials are provided for ranks 2 and 3, both for the representation and character varieties.
Developmental pathways of depressive symptoms via parenting, self-evaluation and peer relationships in young people from 3 to 17 years old: evidence from ALSPAC
Authors: Zhao Mengya , Ford Tamsin , Panayiotou Margarita , Karl Anke 
Published: January 2023

Abstract
Purpose
Self-evaluation and interpersonal factors are theoretically and empirically linked to depression in young people. An improved understanding of the multifactorial developmental pathways that explain how these factors predict depression could inform intervention strategies.

Methods
Using structural equation modeling, this study explored whether self-evaluation and interpersonal factors were associated with adolescent depressive symptoms in a population-based sample (n = 11,921; Avon Longitudinal Study of Parents and Children, ALSPAC), across four development stages: early and late childhood plus early and middle adolescence from 3 to 17 years old.

Results
Early good parenting practices predicted self-esteem, fewer peer difficulties, good friendships and fewer depressive symptoms in late childhood development outcomes. Higher self-esteem and less negative self-concept mediated the effect of early good parenting practice on reduced depressive symptoms in middle adolescence. The hypothesized erosion pathway from depressive symptoms in late childhood via higher levels of negative self-concept in early adolescence to depressive symptoms in middle adolescence was also confirmed. Additionally, peer difficulties played a mediation role in developing depressive symptoms. Contrary to the hypothesis, poor friendships predicted fewer depressive symptoms. The analysis supported a developmental pathway in which good parenting practices in early childhood led to fewer peer difficulties in late childhood and to less negative self-concept in early adolescence, which in turn predicted fewer depressive symptoms in middle adolescence.

Conclusion
The social-developmental origin of youth depressive symptoms was supported via the effect of peer relationships in late childhood on self-evaluation in early adolescence.
Evolving pinched submanifolds of the sphere by mean curvature flow
Authors: Baker Charles , Nguyen Huy The 
Published: January 2023

AbstractIn this paper, we prove convergence of the high codimension mean curvature flow in the sphere to either a round point or a totally geodesic sphere assuming a pinching condition between the norm squared of the second fundamental form and the norm squared of the mean curvature and the background curvature of the sphere. We show that this pinching is sharp for dimension $$n\ge 4$$

n
≥
4

but is not sharp for dimension $$n=2,3$$

n
=
2
,
3

. For dimension $$n=2$$

n
=
2

and codimension 2, we consider an alternative pinching condition which includes the normal curvature of the normal bundle. Finally, we sharpen the Chern–do Carmo–Kobayashi curvature condition for surfaces in the four sphere - this curvature condition is sharp for minimal surfaces and we conjecture it to be sharp for curvature flows in the sphere.
Audiological outcome after stapes surgery in relation to prosthesis type
Authors: Handke Vanessa , Agha-Mir-Salim Parwis , James Paul , Müller Alexander 
Published: January 2023

Abstract
Purpose
Different techniques are used to fix crimp and CliP® Piston stapes prostheses to the long process of the incus (LPI). The CliP® Piston provides a stiff connection in contrast to the static bended loop of the crimp prosthesis, which imitates the physiological incudostapedial joint (ISJ) and thereby potentially leads to different hearing outcome.

Methods
In a retrospective single-center study of German-speaking one hundred and ninety patients who underwent stapes surgery CliP® Piston or crimp prostheses between the years of 2016 and 2019 by the same surgeon and in the same setting. Pre- and postoperative bone- (BC) and air-conduction (AC) pure-tone thresholds, pre- and postoperative air–bone gap (ABG) for 0.5, 1, 1.5, 2, 3, 4 kHz and the surgery time were examined.

Results
The postoperative bone conduction thresholds were significantly lower in the frequencies between 0.5 and 3 kHz and the mean ABG was < 10 dB in most cases independent of the prosthesis used. Crimp prosthesis showed a significantly better closure of the ABG at 0.5 kHz.

Conclusions
The audiological outcome after stapes surgery is dependent on the type of prosthesis used, as reflected by the frequency-specific air–bone gap. The better ABG closure with the crimp prosthesis might be the result of the connection to the LPI imitating the physiological ISJ. The crimp prosthesis may be the better choice if use of hearing aids is expected postoperatively.
From Deutsche Zeitschrift to International Journal of Legal Medicine—100 years of legal medicine through the lens of journal articles
Authors: Schmeling Andreas , Fracasso Tony , Pfeiffer Heidi , Wirth Ingo 
Published: January 2023

Abstract
From volume 67 (1970) onwards, the journal appeared under the new bilingual title Zeitschrift für Rechtsmedizin—Journal of Legal Medicine. The editorial board was expanded and internationalised. From 1970 to 1990, 1416 articles were published in 36 volumes. 1036 articles were in German and 380 in English. The authors of 411 articles came from non-German-speaking countries. Compared to the periods under review in the first two parts of our article series, the proportion of papers on forensic genetics increased significantly between 1970 and 1990, with a small increase in publications on the identification of unknown dead bodies. An opposite trend was observed in the articles on forensic psychiatry and psychology, sexual medicine and social medicine. This development reflects a further sharpening of the discipline’s profile.
Matching-adjusted indirect comparison of asciminib versus other treatments in chronic-phase chronic myeloid leukemia after failure of two prior tyrosine kinase inhibitors
Authors: Atallah Ehab , Mauro Michael J. , Hochhaus Andreas , Boquimpani Carla , Minami Yosuke , Maheshwari Vikalp Kumar , Saini Lovneet , Corbin Regina , Réa Delphine 
Published: January 2023

Abstract
Purpose
The current standard of care for chronic-phase chronic myeloid leukemia (CP-CML) is tyrosine kinase inhibitors (TKIs). Treatment recommendations are unclear for CP-CML failing ≥ 2 lines of treatment, partly due to the paucity of head-to-head trials evaluating TKIs. Thus, matching-adjusted indirect comparisons (MAICs) were conducted to compare asciminib with competing TKIs in third- or later line (≥ 3L) CP-CML.

Methods
Individual patient-level data for asciminib (ASCEMBL; follow-up: ≥ 48 weeks) and published aggregate data for comparator TKIs (ponatinib, nilotinib, and dasatinib) informed the analyses. Major molecular response (MMR), complete cytogenetic response (CCyR), and time to treatment discontinuation (TTD) were assessed, where feasible.

Results
Asciminib was associated with statistically significant improvements in MMR by 6 (relative risk [RR]: 1.55; 95% confidence interval [CI]: 1.02, 2.36) and 12 months (RR: 1.48; 95% CI: 1.03, 2.14) vs ponatinib. For CCyR, the results vs ponatinib were similar by 6 (RR: 1.11; 95% CI: 0.81, 1.52) and 12 months (RR: 0.97; 95% CI: 0.73, 1.28). Asciminib was associated with improvements in MMR by 6 months vs dasatinib but with a CI overlapping one (RR 1.52; 95% CI: 0.66, 3.53). Asciminib was associated with statistically significant improvements in CCyR by 6 (RR: 3.57; 95% CI: 1.42, 8.98) and 12 months (RR: 2.03; 95% CI: 1.12, 3.67) vs nilotinib/dasatinib. Median TTD was unreached for asciminib in ASCEMBL. However, post-adjustment asciminib implied prolonged TTD vs nilotinib and dasatinib, but not vs ponatinib.

Conclusion
These analyses demonstrate favorable outcomes with asciminib versus competing TKIs, highlighting its therapeutic potential in ≥ 3L CP-CML.
Allografts and lateral extra-articular tenodesis for revision anterior cruciate ligament reconstruction: enhanced rotational stability and improved functional outcomes
Authors: Minguell Monyart Joan , Moreira Borim Felipe , Revertè Vinaixa Maria Mercedes , Portas-Torres Irene , Pijoan Bueno Joan , Castellet Feliu Enric , Joshi Jubert Nayana 
Published: January 2023

Abstract
Purpose
Multiple studies have shown higher failure rate and patient-reported outcomes to be significantly worse following revision anterior cruciate ligament reconstructive (ACLR) surgery, especially using allografts. One of the reasons being rotational instability. Because of this, augmentation with lateral extra-articular tenodesis (LET) is often considered. Good short-term results in regards to functional and perceived scores and low complication rate can be expected in revision ACLR using allografts in combination with LET.

Methods
Between 2014 and 2021, 46 patients were registered for revision ACLR using allografts and extra-articular augmentation (modified Lemaire) and included in this prospective study. Patients’ demographic and clinical data were collected preoperatively, postoperatively, and during the follow-up period of 12 months.

Results
Patient-reported functional outcomes were statistically significant for IKDC, Lysholm, and SF-12 physical scale (p < 0.05). Tegner score showed a decreased number of patients who were able to return to sport at their previous level (p = 0.001). Stability examination tests (Lachman and pivot-shift) showed significant improvements. Concomitant lesions were present in 76.1% of patients. Ten patients (21.7%) presented major complications, including six cases of anteroposterior instability, three cases of knee pain and one graft re-rupture.

Conclusion
Revision procedures are inherently challenging with a high number of associated chondral and meniscus lesions. However, good short-term functional outcomes and enhanced rotational stability with an acceptable complication rate can be expected in most cases where revision ACLR using allografts is augmented with LET.

Study design
Prospective; Case series; Level of evidence IV.
Evaluation of perioperative D-dimer concentration for predicting postoperative deep vein thrombosis following hepatobiliary-pancreatic surgery
Authors: Sakamoto Teruhisa , Murakami Yuki , Hanaki Takehiko , Kihara Kyoichi , Matsunaga Tomoyuki , Yamamoto Manabu , Takano Shuichi , Tokuyasu Naruo , Hasegawa Toshimichi , Fujiwara Yoshiyuki 
Published: January 2023

Abstract
Purpose
This study was performed to investigate the predictive value of the perioperative D-dimer concentration for the development of postoperative deep vein thrombosis (DVT) after hepatobiliary-pancreatic (HBP) surgery.

Methods
The subjects of this retrospective study were 178 patients who underwent HBP surgery in our hospital between January, 2017 and December, 2021. The D-dimer concentration was measured preoperatively and on postoperative days (POD) 1, 3, and 5. Postoperative DVT was diagnosed based on compression ultrasonography in both lower limbs on POD 6 or 7.

Results
Postoperative DVT developed in 21 (11.8%) of the 178 patients. The D-dimer concentration was significantly higher in the patients with than in those without postoperative DVT before surgery and on PODs 1, 3, and 5. The highest area under the curve of the D-dimer concentration for predicting DVT was 0.762 on POD 3. Multivariate analysis revealed that the D-dimer concentration on POD 3 was an independent predictive risk factor for postoperative DVT, along with the preoperative estimated glomerular filtration rate. Preoperative albumin and D-dimer concentrations were also identified as independent predictive factors of an increase in D-dimer concentration on POD 3.

Conclusions
The D-dimer concentration on POD 3 is a useful predictor of DVT after HBP surgery.