bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards engineering the perfect defect in high-performing permanent magnets
Authors: Giron Stefan , Pollin Nikita , Adabifiroozjaei Esmaeil , Yang Yangyiwei , Kovacs Andras , Almeida Trevor , Ohmer Dominik , Uestuener Kaan , Katter Matthias , Radulov Iliya , Dunin-Borkowski Rafal , Farle Michael , Durst Karsten , Zhang Hongbin , Alff Lambert , Ollefs Katharina , Xu Bai-Xiang , Gutfleisch Oliver , Molina-Luna Leopoldo , Skokov Konstantin , Gault Baptiste 
Published: May 2023

Abstract

Permanent magnets draw their properties from a complex interplay, across multiple length scales, of the composition and distribution of their constituting phases, that act as building blocks, each with their associated intrinsic properties 1. Gaining a fundamental understanding of these interactions is hence key to decipher the origins of their magnetic performance2 and facilitate the engineering of better-performing magnets, through unlocking the design of the “perfect defects” for ultimate pinning of magnetic domains3. Here, we deployed advanced multiscale microscopy and microanalysis on a bulk Sm2(CoFeCuZr)17 pinning-type high-performance magnet with outstanding thermal and chemical stability 4. Making use of regions with different chemical compositions, we showcase how both a change in the composition and distribution of copper, along with the atomic arrangements enforce the pinning of magnetic domains, as imaged by nanoscale magnetic induction mapping. Micromagnetic simulations bridge the scales to provide an understanding of how these peculiarities of micro- and nanostructure change the hard magnetic behaviour of Sm2(CoFeCuZr)17 magnets. Unveiling the origins of the reduced coercivity allows us to propose an atomic-scale defect and chemistry manipulation strategy to define ways toward future hard magnets.
Geographical Distance Predicts Psychiatric Treatment Retention for Hispanic WomenWith Comorbid Major Depression and Breast Cancer
Authors: CHEN YING , Markowitz John C , Blanco Carlos , Hershman Dawn L , Zhang Joy T , Hellerstein David J 
Published: May 2023

Abstract
Purpose
Depression is among the most common comorbid psychiatric disorders for patients with breast cancer. Depression can decrease patient quality of life and adversely affect cancer treatment if untreated. We sought to identify treatment barriers to women with breast cancer treated with psychotherapy for depression. Findings may help policy makers and researchers determine funding and design of future studies involving this population, especially in communities with high rates of health disparities.
Methods
We used data from a randomized trial for women with breast cancer and current DSM-IV non-psychotic unipolar major depressive disorder (MDD). Patients were randomly assigned to 12 weeks of one of three psychotherapies and attrition was assessed by whether subjects completed 12 weekly treatment sessions. Descriptive analyses and logistic regression were used to identify treatment barriers. R shiny was used to determine the residence of study participants.
Results
Of 134 randomized patients, 84 (62.7%) were Hispanic. Fifty-nine (44%) either did not start or dropped out of treatment, 49 (83.1%) of them Hispanic. Being a Hispanic woman, less educated, and living geographically distant significantly predicted attrition. Single Hispanic mothers had significantly higher attrition risk than married and/or childless women.
Conclusion
Identifying barriers to treatment is important to improve treatment adherence for women with concurrent diagnoses of breast cancer and MDD, especially for traditionally underserved minorities. Additional support, such as affordable tele-medicine, multi-language assistance, financial aid for transportation and child-care, and allocating more funds to assist some identified barriers should be considered to improve treatment adherence and outcomes.
Radiomics-based predictive model of Growth Hormone Status in Children with Short Stature on Contrast-enhanced T1WI Images
Authors: Zhuang Yijiang , Luo Yi , Liao Qianyi , Zhang Siqi , Lin Guisen , Mo Tong , Zeng Hongwu 
Published: May 2023

Abstract
Background
A predictive model for growth hormone status in children were constructed, by extracting radiomic features based on pituitary post-contrast T1WI images, and its evaluation efficacy was assessed.
Methods
Biochemical examination data and MRI data of short stature were collected. All patients were treated in Shenzhen Children's Hospital between October 2019 and December 2019. Patients were divided into two groups, growth hormone normal (GHN) and growth hormone deficient group (GHD), according to growth hormone (GH) peak value. GHN, GH VPeak≥10 ng/ml; GHD, GH VPeak <10 ng/ml. Independent Samples t-tests were employing to evaluate the differences in age between the two groups. The differences in age between the two groups were compared using independent-samples t-tests. Then all patients were randomly divided into training and validation groups by the ratio of 7:3. The ROIs were set as the whole pituitary gland, by drawing the outline of whole gland. Radiomics features were extracted using PyRadiomics package. There are 4 steps in radiomics feature selection: Intra-group Correlation, Independent Sample t-Test, least absolute shrinkage and selection operator (LASSO), and Spearman Correlation Analysis. Building the model with Support Vector Machine, Using Receiver Operating Characteristic (ROC) Curves and calculating the Area Under the Curve (AUC) to evaluate the efficiency of the model.
RESULTS
There were 300 cases of short stature, 136 cases (45.3%) in the GHN, and 164 cases (54.7%) in the GHD. Total 1316 radiomics features were extracted from the images. After 4 steps screening, remaining 13 radiomics features were used for model construction. AUC was used to assessed the predictive accuracy of GH status model; its value for training group and validation group were 0.78 and 0.66 separately.
CONCLUSION
This study builds a practicable and efficiency GH status model for predicting growth hormone status of short stature patients. It provides a novel and non-invasive approach for growth hormone status evaluation, which would be very helpful for clinic treatment strategy decision.
The β-1,4-glucanase gene EuEG1 overexpression improve in vitro micrografting of Eucommia ulmoides
Authors: Wang Lei , Wang Runying , Li Yi , Zhao Yichen , Zhao De-gang 
Published: May 2023

Abstract
The difficulty of adventitious root formation poses a major constraint to the Eucommia ulmoides tissue culture and genetic transformation. Micrografting can provide a new way for in vitro transplantation of genetic transformation. This study used transgenic rootless test-tube seedlings as scions and seedlings from seed as rootstocks for micrografting to avoid the problem of rooting of tissue culture seedlings and study the role of EuEG1 gene in the graft healing process. In this study, it has verified that EuEG1 gene can improve in vitro micrografting of Eucommia ulmoides. Research has found that the overexpression of EuEG1 in transgenic plants (TP) being used as scions for micrografting presented a significantly higher survival rate than the wild-type (WT) and empty vector (EV) regenerated seedling scions. Paraffin section observation showed that more callus tissue appeared at the junction of transgenic scions, and the connection with the rootstock was more complete, which is beneficial for wound healing. The results give new insights into Eucommia ulmoides in vitro micrografting, and indicate that EuEG1 gene can promote wound healing and improve the grafting survival rate.
Extranodal Rosai-Dorfman Disease Manifesting as Sjögren’s Syndrome Combined with Panuveitis and Hypertrophic Pachymeningitis: A Case Report and Review of Literature
Authors: Xu Jing , Huang Meihua , Dong Binsong , Jian Min , Chen Jinyu , Zhang Naiyuan , Ou Chunlian , Wu Yongming , Wang Dongmei 
Published: May 2023

Abstract
Background: Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by massive lymphadenopathy and systemic extranodal lesions.
Case presentation: We present a case of 28-year-old female who presented with recurrent blurred vision in her right eye for 3 months. Her left eye had been blinded and atrophied a decade prior. She subsequently developed a headache, fever, and impaired mental status. Cranial MRI indicated hypertrophic pachymeningitis (HP), and 18F-FDG PET/CT revealed significant FDG uptake in the left dura mater. Autoimmune testing revealed elevated anti-nuclear, anti-SS-A, and anti-SS-B antibodies. Incisional biopsy of the atrophic eyeball revealed RDD with marked polyclonal plasmacytosis. The patient was diagnosed with RDD accompanied by multisystem involvement, including Sjögren’s syndrome (SS), panuveitis, and HP. Treatment with methylprednisolone over several weeks resulted in significant improvement.
Conclusions: This is the first reported case of RDD presenting with SS in combination with panuveitis and HP. Although RDD is rarely diagnosed in young patients, interdisciplinary collaboration is essential to prevent delayed diagnosis.
The Study on Software Architecture Smell Refactoring
Authors: Kuo Jong-Yih , Hsieh Ti-Feng , Lin Yu-De , Lin Hui-Chi 
Published: May 2023

Abstract
Maintenance and complexity issues in software development continue to increase because of new requirements and software evolution, and refactoring is required to help software adapt to the changes. The goal of refactoring is to fix smells in the system. Fixing architectural smells requires more effort than other smells because it is tangled in multiple components in the system. Architecture smells refer to commonly used architectural decisions that negatively impact system quality. They cause high software coupling, create complications when developing new requirements, and are hard to test and reuse. This paper presented a tool to analyze the causes of architectural smells such as cyclic dependency and unstable dependency and included a priority metric that could be used to optimize the smell with the most refactoring efforts and simulate the most cost-effective refactoring path sequence for a developer to follow. Using a real case scenario refactoring path was evaluated with real refactoring execution, and the validity of the path was verified.
Cuproptosis-related genes establishment score system to assess the prognosis and immune microenvironment in cholangiocarcinoma
Authors: Liu Qiang , Zhu Jianpeng , Huang Zhicheng , Bian Ying , Liu Xiaodie , Zhang Jinglei , Zheng Liyun , Gu Ye , Chen Yan , Xu Dongchao , Zhang Xiaofeng , Yang Jianfeng , Shen Hongzhang , Jin Hangbin 
Published: May 2023

Abstract
Background
Cuproptosis is a novel type of mediated cell death strongly associated with the progression of several cancers and has been implicated as a potential therapeutic target. However, the role of cuproptosis in cholangiocarcinoma (CCA) for prognostic prediction, subgroup classification, and therapeutic strategies remains largely unknown.
Methods
A systematic analysis was conducted among 146 cuproptosis-related genes (CRGs) and clinical information based on independent mRNA and protein datasets to elucidate the potential mechanisms and prognostic prediction value of CRGs. A ten-CRG prediction model was constructed, and its effects on CCA prognosis were significantly connected to poor patient survival. Additionally, the expression patterns of our model included genes that were validated with several CCA cancer cell lines and a normal biliary epithelial cell line.
Results
First, a ten-CRG signature (ADAM9, ADAM17, ALB, AQP1, CDK1, MT2A, PAM, SOD3, STEAP3 and TMPRSS6) displayed excellent predictive performance for the overall survival of CCA. The low-cuproptosis group had a significantly better prognosis than the high-cuproptosis group with transcriptome and protein cohorts. Second, compared with the high-risk and low-risk groups, the two groups displayed distinct tumor microenvironments, reduced proportions of endothelial cells and increased levels of cancer-associated fibroblasts based on CIBERSORTx and EPIC analyses. Third, patients’ sensitivities to chemotherapeutic drugs and immune checkpoints revealed distinctive differences between the two groups. Finally, in replicating the expression patterns of the ten genes, these results were validated with qRT‒PCR results validating the abnormal expression pattern of the target genes in CCA.
Conclusions
Collectively, we established and verified an effective prognostic model that could separate CCA patients into two heterogeneous cuproptosis subtypes based on the molecular or protein characteristics of ten CRGs. These findings may provide potential benefits for unveiling molecular characteristics, and defining subgroups could improve the early diagnosis and individualized treatment of CCA patients.
CD39 inhibits increased inflammation and promotes resolution of gout
Authors: Luo chengyu , Liu Xingyue , Shao  , Liu  , Gao Jie , Tao Jinhui 
Published: May 2023

Abstract
Background
Gout is a self-limiting inflammatory arthritis induced by the formation of urate crystals due to hyperuricemia. Recent studies have shown that the pathogenesis of gout involves the participation of extracellular ATP, and the synergistic effect of MSU and extracellular ATP can cause gout. CD39 is an ATP hydrolase that is distributed on the surface of macrophages and almost all other immune cells, and it can inhibit inflammation caused by ATP. This suggests that CD39 may inhibit the aggravation of gout inflammation and participate in the remission mechanism of gout.
Methods
The expression of CD39 mRNA in PBMCs from gout patients, PBMCS from gout model rats and THP-1 cells stimulated by MSU were detected and analyzed. CD39 knockdown was carried out by lentivirus in a monosodium urate (MSU) induced rat model, and CD39 inhibitor was used in MSU induced mouse model. After CD39 was blocked, the activation level of NLRP3 inflammasome and the incidence of gout were observed.
Results
The results showed that the deletion of CD39 aggravated MSU-induced gouty arthritis and delayed the remission of gout. Furthermore, it promoted the activation of the NLRP3 inflammasome signaling pathway and the release of IL-1βin macrophages.
Conclusions
Our results confirm that CD39 is elevated in the gout inflammatory environment, and its presence inhibits the aggravation of inflammation and promotes the resolution of gout.
Biomarkers in endurance exercise - Individualized regulation and predictive value
Authors: Hacker Sebastian , Keck Johannes , Reichel Thomas , Eder Klaus , Ringseis Robert , Krüger Karsten , Krüger Britta 
Published: May 2023

Abstract

Objectives The high inter-individual variability of exercise response complicates the efficient use of blood-based biomarkers in sports. To address the problem, a useful algorithm to characterize the individual regulation and predictive value of different candidate markers will be developed.Methods Forty-nine participants completed two identical exercise trials. Blood samples were collected before, immediately after, 3 hours after and 24 hours after completion of exercise. Plasma concentrations of interleukin (IL-) 1RA, IL-8, IL-15, IL-10, CK, CRP, LDH, cortisol and thiobarbituric acid reactive substances (TBARS) were measured. Individualized regulation was analyzed using k-means clustering and a Group Assignment Quality Score (GAQ). Regression trees with a bootstrapped-aggregated approach were used to assess the predictive qualities of the markers.Results For most of the markers studied, a distinction can be made between individuals who show a stronger or weaker response to a particular endurance training program. The regulation for IL-10, IL-6, IL-8 and CK exhibited a high degree of stability within the individuals. Regarding the predictive power of the markers, for all dependent variables, the most accurate predictions were obtained for cortisol and IL-8 based on the baseline value. For CK, a good prediction of recovery of maximal strength and subjective feeling of exhaustion can be made. For IL-1RA and TBARS, especially their re-regulation can be predicted if the baseline level is known.Perspectives Focusing individual variations in biomarker responses, our results suggest the combined use of IL-6, IL-8, IL-10, and CK for the personalized management of stress and recovery cycles following endurance exercise.
NOD-like-receptor signaling pathway mediates inflammation and triggers cerebral injury in cerebral venous thrombosis
Authors: Zhou Yifan , Jiang Huimin , Wei Huimin , Xiao Xuechun , Liu Lu , Zhou Chenxia , Ma Wei , Ji Xunming , Zhou Chen 
Published: May 2023

Abstract
Background
Cerebral venous thrombosis (CVT) is a special type of stroke with an increasing incidence. However, the pathophysiological mechanisms remain elusive, which hinders a comprehensive understanding of CVT. We used a CVT model in rats to elucidate the mechanism of neurological damage.
Methods
We constructed a CVT model to examine neurological function and performed neuroimaging. RNA-Seq and biological information technology were utilized to analyze the transcriptome features of the Sham, middle cerebral artery occlusion (MCAO), and CVT groups, subsequently selecting significantly upregulated signaling pathways in the CVT rat brain. The activation of signaling pathways and immune cells in CVT was confirmed through flow cytometry (FC), real-time quantitative polymerase chain reaction (qPCR), and immunofluorescence staining (IF).
Results
Twenty-four hours after CVT establishment, rats exhibited significant Magnetic resonance imaging (MRI)-T2 hyperintensity and neurological impairment compared to sham rats. Transcriptome profiling showed that the inflammatory response was a significant and specific characteristic of the CVT group compared with the sham and MCAO groups. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of differentially expressed genes (DEGs) indicated that the DEGs were mainly enriched in the gene set of inflammation-related responses. Single-sample gene set enrichment analysis (ssGSEA) also suggested that the immune inflammatory response score was increased significantly. Furthermore, Immune-AI mouse revealed that microglia were the most significantly elevated immune inflammatory cells after CVT. GSEA indicated that the nucleotide-binding oligomerization domain (NOD)-like-receptor signaling pathway was significantly upregulated compared to other inflammatory signaling pathways, and then, key driver analysis (KDA) of DEGs in the NOD-like-receptor signaling pathway revealed that Nod-2 and other genes were the core genes. Importantly, inhibiting the NOD-like-receptor signaling pathway in CVT rats resulted in neurological function improvement and infarct size reduction.
Conclusions
The microglia-mediated inflammatory response and NOD-like-receptor signaling pathway activation are significant pathological changes in brain injury after CVT. This study may enhance comprehension of the pathological mechanisms underlying CVT and provide novel insights for further investigation into injuries in CVT.
Cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma compared to population norms and healthy controls: an exploratory study
Authors: Gates Priscilla , Dhillon Haryana. M , Krishnasamy Mei , Wilson Carlene , Gough Karla 
Published: May 2023

Abstract
Purpose
Cancer-related cognitive impairment is an adverse consequence of cancer and its treatment. There has been little research with patients with aggressive lymphoma. We describe self-reported cognitive function and neuropsychological performance data in patients with lymphoma and compare them with healthy controls and population norms. Associations between patients’ neuropsychological performance, cognitive function and distress are also examined.
Methods
Secondary analysis of data from a longitudinal feasibility study of 30 participants with newly diagnosed aggressive lymphoma and 72 healthy controls was performed. Participants completed validated self-report measures and neuropsychological tests before, and 6–8 weeks after chemotherapy. Healthy controls completed the FACT-Cog and neuropsychological tests at enrolment and six-months later. Mixed models were used to analyse FACT-Cog and neuropsychological test scores. Kendall’s Tau provided a measure of association between global deficit and data from other measures.
Results
Patients and healthy controls were well matched on demographics. Differences between the two groups’ neuropsychological test scores were mostly large-sized; patients’ performance was poorer both before and after chemotherapy (most p < 0.001). The same pattern was observed for impact of perceived cognitive impairment on quality-of-life (both p < 0.001), but not perceived cognitive impairment or abilities (all p > 0.10). Associations between neuropsychological performance, self-reported cognitive function and distress, were trivial to small-sized (all p > 0.10).
Conclusion
For many patients with aggressive lymphoma, impaired neuropsychological test performance and impact of perceived impairments on quality-of-life precede chemotherapy and are sustained 6–8 weeks after chemotherapy. Our data support the need for further longitudinal studies with this population to better understand targets for interventions to address cognitive impairment.
The effect of fatigue on postural control in individuals with multiple sclerosis: A systematic review
Authors: Sedaghati Parisa , Alghosi Mohammad , Hosseini Freshteh 
Published: May 2023

Abstract
Background: Fatigue is the most disabling ‎symptom for individuals with multiple ‎sclerosis which can significantly affect postural control by impairing the ability of the central nervous system to modulate sensory inputs and coordinate motor responses. This systematic review aimed to accumulate the existing evidence. This systematic review aimed to investigate the effect of ‎fatigue on postural control in individuals with multiple ‎sclerosis.‎
Methods: This systematic review was performed in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement and registered in PROSPERO with ID CRD42022376262‎. Web of Science, PubMed, Scopus, and Google Scholar was systematically searched until January 2023, and a manual search was performed using the reference lists of included studies. Two authors independently selected the studies, extracted data, and evaluated their ‎methodological quality using the Downs and Black checklist. The process was later discussed ‎with a third author.‎
Results: Five studies were included in this review, of which consistent evidence investigating a direct ‎relationship between fatigue and ‎postural control in individuals with multiple ‎sclerosis. All the studies reported negative effects on postural control. Four ‎studies executed walking tests as fatigue protocols, and one study used a strength testing protocol for both legs, which served as a fatigue-inducing activity‎.
Conclusions: The available evidence suggests that individuals with multiple ‎sclerosis may experience postural control deficits due to fatigue. However, the present body of literature exhibits limitations in terms of its quality and methodology. Gender differences, balance, fatigue task, and muscle function are important factors that need to be taken into account when investigating the relationship between fatigue and postural control deficits in MS. Further high-quality research is necessary to comprehend the complex interplay between MS-related fatigue and postural control deficits after physical activity.