bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of indocyanine green-mediated fluorescence molecular imaging technology in liver tumors resection: a systematic review and meta-analysis
Authors: Zhu Gang , Qiu Xing , Zeng Longfei , Zou Zhirui , Yang Liu , Nie Shanmao , Wang Zuanyu , Zhang Xin , Tang Jinquan , Pan Yong , Tang Shaozhen , Wu Tao 
Published: June 2023

BackgroundThis meta-analysis was dedicated to evaluating the safety and effectiveness of indocyanine green (ICG) -mediated fluorescence molecular imaging (FMI) technology in liver tumors resection.MethodsA literature search of PubMed, Embase databases, Cochrane Library, and Web of Science was performed to identify all clinical controlled studies exploring the effects of fluorescence imaging on liver tumors resection. Quality assessment and data extraction of studies were conducted independently by 3 reviewers. Mean difference (MD) and odds ratio (OR) with 95% confidence interval (CI) were calculated using a fixed-effects or random-effects model. The meta-analysis was performed with RevMan 5.3 software.Results14 retrospective cohort studies (RCSs) involving a total of 1227 patients were finally included. The results showed that Fluorescence-assisted liver tumors resection could improve the R0 resection rate (OR = 2.63; 95% CI: 1.46~4.73, p = 0.001), reduce overall complications (OR = 0.66; 95% CI: 0.44~0.97, p = 0.04), biliary fistula (OR = 0.20; 95% CI: 0.05~0.77, p = 0.02), intraoperative blood loss (MD = −70.76, 95% CI: −106.11 to −35.41; p &lt; 0.0001), and shortens hospital stay (MD = −1.41, 95% CI: −1.90 to −0.92; p &lt; 0.00001). There were no significant differences in the incidences of operative time (MD = −8.68, 95% CI: −18.59 to −1.22; p = 0.09), complications of grade III or above (OR = 0.73; 95% CI: 0.43~1.25, p = 0.26), liver failure (OR = 0.86; 95% CI: 0.39~1.89, p = 0.71), and blood transfusion (OR = 0.66; 95% CI: 0.42~1.03, p = 0.07).ConclusionCurrent evidence suggests that ICG-mediated FMI technology could enhance the clinical effectiveness of patients with liver tumors resection and is clinically worthy of promotion.Systematic review registrationPROSPERO, identifier CRD42022368387.
Metabolic bulk volume predicts survival in a homogeneous cohort of stage II/III diffuse large B-cell lymphoma patients undergoing R-CHOP treatment
Authors: Jin Hyun , Jin Myung , Lim Chae Hong , Choi Joon Young , Kim Seok-Jin , Lee Kyung-Han 
Published: June 2023

PurposeAccurate risk stratification can improve lymphoma management, but current volumetric 18F-fluorodeoxyglucose (FDG) indicators require time-consuming segmentation of all lesions in the body. Herein, we investigated the prognostic values of readily obtainable metabolic bulk volume (MBV) and bulky lesion glycolysis (BLG) that measure the single largest lesion.MethodsThe study subjects were a homogeneous cohort of 242 newly diagnosed stage II or III diffuse large B-cell lymphoma (DLBCL) patients who underwent first-line R-CHOP treatment. Baseline PET/CT was retrospectively analyzed for maximum transverse diameter (MTD), total metabolic tumor volume (TMTV), total lesion glycolysis (TLG), MBV, and BLG. Volumes were drawn using 30% SUVmax as threshold. Kaplan–Meier survival analysis and the Cox proportional hazards model assessed the ability to predict overall survival (OS) and progression-free survival (PFS).ResultsDuring a median follow-up period of 5.4 years (maximum of 12.7 years), events occurred in 85 patients, including progression, relapse, and death (65 deaths occurred at a median of 17.6 months). Receiver operating characteristic (ROC) analysis identified an optimal TMTV of 112 cm3, MBV of 88 cm3, TLG of 950, and BLG of 750 for discerning events. Patients with high MBV were more likely to have stage III disease; worse ECOG performance; higher IPI risk score; increased LDH; and high SUVmax, MTD, TMTV, TLG, and BLG. Kaplan–Meier survival analysis showed that high TMTV (p = 0.005 and &lt; 0.001), MBV (both p &lt; 0.001), TLG (p &lt; 0.001 and 0.008), and BLG (p = 0.018 and 0.049) were associated with significantly worse OS and PFS. On Cox multivariate analysis, older age (&gt; 60 years; HR, 2.74; 95% CI, 1.58–4.75; p &lt; 0.001) and high MBV (HR, 2.74; 95% CI, 1.05–6.54; p = 0.023) were independent predictors of worse OS. Older age (hazard ratio [HR], 2.90; 95% CI, 1.74–4.82; p &lt; 0.001) and high MBV (HR, 2.36; 95% CI, 1.15-6.54; p = 0.032) were also independent predictors of worse PFS. Furthermore, among subjects ≤60 years, high MBV remained the only significant independent predictor of worse OS (HR, 4.269; 95% CI, 1.03–17.76; p = 0.046) and PFS (HR, 6.047; 95% CI, 1.73–21.11; p = 0.005). Among subjects with stage III disease, only greater age (HR, 2.540; 95% CI, 1.22–5.30; p = 0.013) and high MBV (HR, 6.476; 95% CI, 1.20–31.9; p = 0.030) were significantly associated with worse OS, while greater age was the only independent predictor of worse PFS (HR, 6.145; 95% CI, 1.10–4.17; p = 0.024).ConclusionsMBV easily obtained from the single largest lesion may provide a clinically useful FDG volumetric prognostic indicator in stage II/III DLBCL patients treated with R-CHOP.
Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models
Authors: Kaehler Meike , Osteresch Pia , Künstner Axel , Vieth Stella Juliane , Esser Daniela , Möller Marius , Busch Hauke , Vater Inga , Spielmann Malte , Cascorbi Ingolf , Nagel Inga 
Published: June 2023

IntroductionResistance in anti-cancer treatment is a result of clonal evolution and clonal selection. In chronic myeloid leukemia (CML), the hematopoietic neoplasm is predominantly caused by the formation of the BCR::ABL1 kinase. Evidently, treatment with tyrosine kinase inhibitors (TKIs) is tremendously successful. It has become the role model of targeted therapy. However, therapy resistance to TKIs leads to loss of molecular remission in about 25% of CML patients being partially due to BCR::ABL1 kinase mutations, while for the remaining cases, various other mechanisms are discussed.MethodsHere, we established an in vitro-TKI resistance model against the TKIs imatinib and nilotinib and performed exome sequencing.ResultsIn this model, acquired sequence variants in NRAS, KRAS, PTPN11, and PDGFRB were identified in TKI resistance. The well-known pathogenic NRAS p.(Gln61Lys) variant provided a strong benefit for CML cells under TKI exposure visible by increased cell number (6.2-fold, p &lt; 0.001) and decreased apoptosis (-25%, p &lt; 0.001), proving the functionality of our approach. The transfection of PTPN11 p.(Tyr279Cys) led to increased cell number (1.7-fold, p = 0.03) and proliferation (2.0-fold, p &lt; 0.001) under imatinib treatment.DiscussionOur data demonstrate that our in vitro-model can be used to study the effect of specific variants on TKI resistance and to identify new driver mutations and genes playing a role in TKI resistance. The established pipeline can be used to study candidates acquired in TKI-resistant patients, thereby providing new options for the development of new therapy strategies to overcome resistance.
Restoration of soil quality of degraded grassland can be accelerated by reseeding in an arid area of Northwest China
Authors: Lu Qi , Ma Hongbin , Zhou Yao , Liu Jindi , Shen Yan 
Published: June 2023

Grassland restoration measures control soil degradation and improve soil quality (SQ) worldwide, but there is little knowledge about the effectiveness of restoration measures affecting SQ in arid areas, and the restoration rate of degraded grasslands to natural restoration grasslands and reseeded grasslands remains unclear. To establish a soil quality index (SQI) to evaluate the effects of different grassland restoration measures on SQ, continuous grazing grassland (CG) (as a reference), grazing exclusion grassland (EX), and reseeding grassland (RS) were selected and sampled in the arid desert steppe. Two soil indicator selection methods were conducted (total data set (TDS) and minimum data set (MDS)), followed by three SQ indices (additive soil quality index (SQIa), weighted additive soil quality index (SQIw), and Nemoro soil quality index (SQIn)). The results indicated that SQ was better assessed using the SQIw(R2 = 0.55) compared to SQIaand SQInfor indication differences among the treatments due to the larger coefficient of variance. The SQIw-MDS value in CG grassland was 46% and 68% lower than that of EX grassland and RS grassland, respectively. Our findings provided evidence that restoration practices of grazing exclusion and reseeding can significantly improve the SQ in the arid desert steppe, and native plant reseeded can accelerate soil quality restoration.
Parent-implemented augmented communication intervention and young children with Down syndrome: an exploratory report
Authors: Romski MaryAnn , Sevcik Rose A. , Barton-Hulsey Andrea , Fisher Evelyn , King Marika , Albert Phebe , Kaldes Gal , Walters Casy 
Published: June 2023

IntroductionYoung children with Down syndrome (DS) present with speech and language impairments very early in childhood. Historically, early language intervention for children with DS included manual signs, though recently there has been an interest in the use of speech-generating devices (SGDs). This paper examines the language and communication performance of young children with DS who participated in parent-implemented communication interventions that included SGDs. Specifically, we compared the functional vocabulary usage and communication interaction skills of children with DS who received augmented communication interventions (AC) that included an SGD with those children with DS who received spoken communication intervention (SC).MethodsTwenty-nine children with DS participated in this secondary data analysis. These children were part of one of two longitudinal RCT studies investigating the effectiveness of parent-implemented augmented communication interventions in a larger sample of 109 children with severe communication and language impairments.ResultsThere were significant differences between children with DS in the AC and SC groups in terms of the number and proportion of functional vocabulary targets used and the total vocabulary targets provided during the intervention at sessions 18 (lab)and 24 (home).DiscussionOverall, the AC interventions provided the children with a way to communicate via an SGD with visual-graphic symbols and speech output, while the children in the SC intervention were focused on producing spoken words. The AC interventions did not hinder the children’s spoken vocabulary development. Augmented communication intervention can facilitate the communication abilities of young children with DS as they are emerging spoken communicators.
Chasing elusive expressive writing effects: emotion-acceptance instructions and writer engagement improve outcomes
Authors: Rude Stephanie S. , Lantrip Crystal , Aguirre Vanessa A. , Schraegle William A. 
Published: June 2023

IntroductionPennebaker’s expressive writing (EW) paradigm in which participants are encouraged to explore their “deepest thoughts and feelings” about a difficult experience in several short writing sessions has yielded impressive mental health outcomes and holds great promise as a cost-effective intervention. Yet results have been difficult to replicate and it is unclear what conditions are necessary for observing the effect. Our aim was to discover reasons for the variability in EW outcomes. We explored the impact of augmenting writing instructions to encourage acceptance of emotional experience, which we thought would encourage engagement with writing; and we examined essay length, an index of writer engagement, as a possible moderator of writing outcomes.MethodsWe compared traditional expressive writing (tEW), conducted according to Pennebaker’s paradigm in which participants write about a self-chosen emotional experience for 15 min at a time on each of three closely spaced days, with an acceptance-enhanced version (AEEW), identical except that it supplemented traditional instructions with encouragement of an accepting approach to emotional experience, and with a control condition which asked participants to write about their use of time on particular days. Self-reported depression was the outcome measure.ResultsEssay length (a proxy for writer engagement) moderated effects of writing at posttest 2 weeks later: Condition differences were found only for participants who wrote longer essays: For these participants the AEEW condition outperformed both control and tEW; and tEW did not differ significantly from control.ConclusionFindings suggest that degree of engagement in the writing process may partially explain the puzzle of variable outcomes in the EW literature. Results also provide practical guidance: those who are motivated to engage deeply in the writing process are most likely to benefit; and encouraging writers to accept and to openly explore emotional experience is expected to enhance benefits.
A multi-country One Health foodborne outbreak simulation exercise: cross-sectoral cooperation, data sharing and communication
Authors: Alves Frederico , Artursson Karin , Bloch Juliette , Brisabois Anne , Imberechts Hein , Jokelainen Pikka , La Ragione Roberto , Lindblad Mats , Forss Rebecca Litzell , Marston Denise A. , Parvizi Omid , Tuominen Lena , Omazic Anna 
Published: June 2023

IntroductionThe awareness of scientists and policy makers regarding the requirement for an integrated One Health (OH) approach in responding to zoonoses has increased in recent years. However, there remains an overall inertia in relation to the implementation of practical cross-sector collaborations. Foodborne outbreaks of zoonotic diseases continue to affect the European population despite stringent regulations, evidencing the requirement for better ‘prevent, detect and response’ strategies. Response exercises play an essential role in the improvement of crisis management plans, providing the opportunity to test practical intervention methodologies in a controlled environment.MethodsThe One Health European Joint Programme simulation exercise (OHEJP SimEx) aimed at practicing the OH capacity and interoperability across public health, animal health and food safety sectors in a challenging outbreak scenario. The OHEJP SimEx was delivered through a sequence of scripts covering the different stages of a Salmonella outbreak investigation at a national level, involving both the human food chain and the raw pet feed industry.ResultsA total of 255 participants from 11 European countries (Belgium, Denmark, Estonia, Finland, France, Italy, Norway, Poland, Portugal, Sweden, the Netherlands) took part in national level two-day exercises during 2022. National evaluations identified common recommendations to countries aiming to improve their OH structure to establish formal communication channels between sectors, implement a common data sharing platform, harmonize laboratory procedures, and reinforce inter-laboratory networks within countries. The large proportion of participants (94%) indicated significant interest in pursuing a OH approach and desire to work more closely with other sectors.DiscussionThe OHEJP SimEx outcomes will assist policy makers in implementing a harmonized approach to cross-sector health-related topics, by highlighting the benefits of cooperation, identifying gaps in the current strategies and suggesting actions required to better address foodborne outbreaks. Furthermore, we summarize recommendations for future OH simulation exercises, which are essential to continually test, challenge and improve national OH strategies.
Spousal concordance in adverse childhood experiences and the association with depressive symptoms in middle-aged and older adults: findings across China, the US, and Europe
Authors: Sun Weidi , Ren Ziyang , Zhu Siyu , Cheng Siqing , Liu Wen , Li Ho Cheung William , Xia Wei , Yuan Changzheng , Adeloye Davies , Rudan Igor , Canoy Dexter , Song Peige 
Published: June 2023

BackgroundAdverse childhood experiences (ACEs) are associated with higher depressive risks in adulthood. Whether respondents’ ACEs are associated with their own depressive symptoms in adulthood and whether this association extends to their spouses’ depressive symptoms remain unexplored.MethodsData were from China Health and Retirement Longitudinal Study (CHARLS), the Health and Retirement Study (HRS), and the Survey of Health, Ageing and Retirement in Europe (SHARE). ACEs were categorized into overall, intra-familial, and extra-familial ACEs. Correlations of couples’ ACEs were calculated using Cramer’s V and partial Spearman’s correlation. Associations of respondents’ ACEs with spousal depressive symptoms were assessed using logistic regression, and mediation analyses were conducted to explore the mediating role of respondents’ depressive symptoms.ResultsSignificant associations between husbands’ ACEs and wives’ depressive symptoms, with odds ratios (ORs) and 95% confidence intervals (CIs) of 2.09 (1.36–3.22) for 4 or more ACEs in CHARLS, and 1.25 (1.06–1.48) and 1.38 (1.06–1.79) for 2 or more ACEs in HRS and SHARE. However, wives’ ACEs were associated with husbands’ depressive symptoms only in CHARLS and SHARE. Findings in intra-familial and extra-familial ACEs were consistent with our main results. Additionally, respondents’ depressive symptoms mediated more than 20% of the effect of respondents’ ACEs on spousal depressive symptoms.ConclusionWe found that ACEs were significantly correlated between couples. Respondents’ ACEs were associated with spousal depressive symptoms, with respondents’ depressive symptoms mediating the association. The bidirectional implications of ACEs on depressive symptoms should be considered within household and effective interventions are warranted.
Associations between underlying diseases with COVID-19 and its symptoms among adults: a cross-sectional study
Authors: Wang Binghan , Yuan Shuyan , Ruan Shuke , Ning Xiuyuan , Li Hanrui , Liu Yuanhao , Li Xiuyang 
Published: June 2023

BackgroundSpecific underlying diseases were reported to be associated with severe COVID-19 outcomes, but little is known about their combined associations. The study was aimed to assess the relations of number of and specific underlying diseases to COVID-19, severe symptoms, loss of smell, and loss of taste.MethodsA total of 28,204 adult participants in the National Health Interview Survey 2021 were included. Underlying diseases (including cardiovascular diseases, cancer, endocrine diseases, respiratory diseases, neuropsychiatric diseases, liver and kidney diseases, fatigue syndrome, and sensory impairments), the history of COVID-19, and its symptoms were self-reported by structured questionnaires. Multivariable logistic regression models were used to assess the combined relation of total number of underlying diseases to COVID-19 and its symptoms, while mutually adjusted logistic models were used to examine their independent associations.ResultsAmong the 28,204 participants (mean ± standard deviation: 48.2 ± 18.5 years), each additional underlying disease was related to 33, 20, 37, and 39% higher odds of COVID-19 (odds ratio [OR]: 1.33, 95% confidence interval [CI]: 1.29–1.37), severe symptoms (OR: 1.20, 95% CI: 1.12–1.29), loss of smell (OR: 1.37, 95% CI: 1.29–1.46), and loss of taste (OR: 1.39, 95% CI: 1.31–1.49). In addition, independent associations of sensory impairments with COVID-19 (OR: 3.73, 95% CI: 3.44–4.05), severe symptoms (OR: 1.37, 95% CI: 1.13–1.67), loss of smell (OR: 8.17, 95% CI: 6.86–9.76), and loss of taste (OR: 6.13, 95% CI: 5.19–7.25), cardiovascular diseases with COVID-19 (OR: 1.13, 95% CI: 1.03–1.24), neuropsychiatric diseases with severe symptoms (OR: 1.41, 95% CI: 1.15–1.74), and endocrine diseases with loss of taste (OR: 1.28, 95% CI: 1.05–1.56) were observed.ConclusionA larger number of underlying diseases were related to higher odds of COVID-19, severe symptoms, loss of smell, and loss of taste in a dose–response manner. Specific underlying diseases might be individually associated with COVID-19 and its symptoms.
Outcomes of Emergency Groin Hernia Repair in the Elderly: A Systematic Review
Authors: Piltcher-da-Silva Rodrigo , Sasaki Vivian Laís , Bettini Luiz Francisco Cravo , Soares Pedro San Martin , Valandro Isabelle Garibaldi , Cavazzola Leandro Totti 
Published: June 2023

Introduction: The number of surgeries for groin hernia (GH) among the elderly follows the increase in life expectancy of the population. The greater number and severity of comorbidities in this group increases the surgical risk, promoting discussion regarding the indication of elective surgery and the benefits of watchful waiting approach (WWA). The aim of the present study was to evaluate the outcomes of emergency hernia surgery among the elderly population.Materials and methods: A systematic review was performed in Pubmed and Scielo databases for the past early 10 years, until July 2022. The subject was groin hernia in the emergency setting focusing the elderly population. The PRISMA statement was followed and the classification of elderly was based on the World Health Organization’s definition.Results: A total of 1,037 results were returned and we ended with nine original articles with emphasis in groin hernia in the emergency among the elderly population. In these subjects, the complications rate ranged between 21.2% and 28.9% and the mortality rate ranged between 1.2% and 6%. Cardiopulmonary disease, high ASA and Charlson’s scales were associated with greater risk of complications and death.Conclusion: Emergency GH surgery in the elderly population carries an increased risk of complications and mortality. GH surgery is safe or, at least, less harmful when done electively. The risk and benefits of WWA and upfront surgery needs to be assessed and exposed to the patients. Our review sugest that elective surgery should be the option over WWA in this patient population.
Liderazgo y personalización de la política. Sánchez y Casado en las elecciones generales de 2019: el papel constructor de las televisiones generalistas al bipartidismo
Authors: Pop Anastasia-Ioana , Marín Pérez Benjamín , Pérez-Sánchez Javier 
Published: June 2023

El artículo aborda la cobertura televisiva de los principales líderes y partidos candidatos a la presidencia del gobierno de España durante las dos elecciones generales de 2019. El objetivo es ofrecer un análisis del tratamiento que las cadenas más importantes, TVE, Antena 3 y Telecinco hicieron de las dos campañas electorales en sus informativos de máxima audiencia para medir su aportación a la personalización de la política a través de los líderes y comprobar si contribuyen al posicionamiento mediático de unos partidos más que a otros. Se sustenta en un método cuantitativo, identificando diferentes elementos comunes, y complementado con un análisis cualitativo basado en el estudio del contenido de las noticias. En ambos casos se tienen en cuenta las menciones a los candidatos y partidos a través de las entradillas del presentador, la voz en off del periodista, la rotulación, el contenido de las imágenes y las intervenciones de los líderes que aparecen en las 266 piezas que se han estudiado. Las cadenas, además de dar mayor protagonismo a los líderes que a los propios partidos, privilegian la figura de Pablo Casado y Pedro Sánchez sobre el resto de los candidatos. Los informativos analizados otorgan un mayor protagonismo a los líderes del PSOE y del PP que a los del resto de fuerzas políticas, contribuyendo de esta manera al bipartidismo en España.