bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trauma-Informed Care Practices to Support Caregivers of Children with Severe Illness: Protocol for A Systematic Review
Authors: Jibb Lindsay Anne , Pomeroy Beverley Claire , Carriere Carmen , Hashemi Elham , Zaffino Isabella , Panesar Prabdeep , Hwang Kyobin , Mitchell Mikaela , Hildenbrand Aimee , Coleman Mary , Lee Esther Joomi 
Published: July 2023

Abstract
Background
Family caregivers of children with life-limiting illness or chronic complex medical conditions experience significant psychological challenges related to the diagnosis, treatment, and care of their child. Trauma-informed (or trauma- and resiliency-informed) care interventions targeted at directly preventing or managing trauma-related symptoms using psychological approaches have potential to improve distress and distress-related symptoms among caregivers. The overall objective of this parent-led systematic review is to synthesize the literature on the effect of trauma-informed care services for the prevention and management of traumatic stress and related symptoms in the family caregivers of children with life-limiting or complex medical conditions.
Methods
Our systematic review will identify studies reviewing the effectiveness of trauma-informed care services for the prevention and management of traumatic stress and related symptoms in family caregivers. We will search Medline, PsycInfo, Embase, CINAHL, Cochrane CENTRAL, the Applied Social Sciences Index and Abstracts, and Social Services Abstracts databases for articles describing trauma-informed care interventions for these family caregivers. All titles and abstracts will be screened independently and in duplicate with discrepancies resolved by caregivers with lived experience. The same process will be used for full-text articles. Data abstraction will also be conducted independently and in duplicate with team members who are caregivers resolving discrepancies. Data analysis will involve syntheses of study results to better understand intervention effect and related complexities.
Discussion
This family caregiver initiated- and co-lead systematic review will identify, appraise, and report on the effectiveness of trauma-informed care interventions aiming to prevent or manage traumatic stress and related symptoms in the family caregivers of children with life limiting illnesses. This review will provide needed data to inform the co-design and implementation of high-quality care services aimed at health improvements for families of children with life-limiting or chronic complex medical conditions.
Systematic review registration: PROSPERO 2022 CRD42022331536 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022331536
Efficient plunge milling cutter and process for two-dimensional cavity
Authors: Guo Minglong , Wei Zhaocheng , Wang Dong , Zhang Zhihong , He Shaolin , Li Jiasheng 
Published: July 2023

Abstract
Plunge milling, as a recognized high-efficiency metal cutting process, is an ideal choice for roughing machining of deep groove and cavity parts. However, due to the severe cutting load of plunge milling, especially the problem of plunge milling collision, and the lack of cavity plunge milling process, its engineering application has always been unsatisfactory. In this paper, starting from the cutter design, the inward-inclined structure of cutting edge is proposed, which can effectively avoid the sharp increase in cutting load caused by plunge milling collision, and realize in-situ cutter retraction. At the same time, the dislocation chip-separation structure of cutting edge is also proposed, which can effectively reduce the plastic deformation of cutting layer, and the maximum cutting force is reduced by about 55%. Based on the design of above high-performance plunging cutter, considering the constraints of material residue and isolated corner, the plunging milling process strategies for open cavity, semi-closed cavity and closed cavity are planned. Finally, the influence law of machining parameters on cutting force is explored. The set up series of verification experiments show that the inward-inclined structure and dislocation chip-splitting structure of plunge milling cutter are reasonable, and the process strategies and machining parameters of cavity plunge milling are feasible. Compared with the traditional layer milling, the machining efficiency is increased by about 3.3 times.
DFT and TD-DFT calculation of new aryl cyanomethylene-quinone mono-oximes-based small molecules for organic photovoltaic
Authors: lakrikh Siham , hachim mouhi eddine , Ghaleb adib 
Published: July 2023

Abstract
We calculated electrical characteristics of eight compounds based on aryl-cyano-methylene-quinone mono-oximes using density functional theory (DFT) with base set B3LYP/6-311G (d). Some of theoretical factors, such as energy of HOMO (EHOMO), energy of LUMO (ELUMO), and Gap energy (Egap) are highly relevant in the photovoltaic sector. On the other hand, we investigated our results by determining electronic and spectroscopic properties using TD-DFT and with base set B3LYP/6-311G (d), in order to define the wavelengths of studied molecules, tracing the visible and ultra-violet spectrum, and determine the transition states. The achieved results and developed attributes show that these molecules could be extremely efficient in the renewable energy industry.
Clinical and epidemiological features of Lyme neuroborreliosis in adults and factors associated with polyradiculitis, facial palsy and encephalitis or myelitis
Authors: Radzišauskienė Daiva , Urbonienė Jurgita , Jasionis Arminas , Klimašauskienė Aušra , Malickaitė Radvilė , Petrulionienė Agnė , Vitkauskaitė Monika , Kaubrys Gintaras 
Published: July 2023

Abstract
The clinical course of Lyme neuroborreliosis (LNB) is highly variable. Delayed diagnosis and treatment still remain actual challenges. Moreover, there is a lack of studies analyzing the factors associated with different LNB syndromes. We aimed to analyze clinical and epidemiological features of LNB in hospitalized adults. A retrospective study was performed in the years 2010–2021. A total of 103 patients were involved in the study, 100 with early, and three with late LNB. Patients with early LNB most often presented polyradiculitis (75/100, (75%)), which was also the most common initial neurological syndrome. Peripheral facial palsy was diagnosed in 53/100 (53%) patients, in 16/53 (30.2%) cases both facial nerves were affected. Encephalitis or myelitis was diagnosed in 14% of patients with LNB. A total of 76/103 (73.8%) patients were discharged with residual symptoms or signs. One patient presenting encephalomyelitis died because of bacterial complications. We found that female sex and untreated erythema migrans (EM) were associated with the development of isolated polyradiculitis, the absence of EM was associated with the development of peripheral facial palsy, and a fever of ≥ 38˚C and pleocytosis of ≥ 300x106/l were associated with encephalitis or myelitis in patients with early LNB.
Assessing multiple free-roaming dog control strategies in a flexible agent-based model
Authors: Yoak A. J. , Calinger K. , Hiby E. 
Published: July 2023

Abstract
Management of free-roaming dog populations is required to mitigate the threat of pathogens like rabies, minimize conflict with people, wildlife, and livestock and improve dog welfare. Historically, lethal removal has been the primary management tool, but is giving way to more humane sterilization and vaccination strategies. However, the implementation of control can vary widely between locations. This work describes an agent-based stochastic model, ‘StreetDogSim’ that can be used as a planning tool to investigate the predicted impact of different strategies with variable implementation approaches and adjustable parameters to match local conditions. Here, we explore the effects of different management strategies including lethal, vaccine-only, and vaccinate and sterilize, with additional variation in their duration, intensity, and vaccine quality on important population metrics such as overall size, demographics, vaccination coverage, time until effective population suppression, and duration of suppression. Under most model parameterizations, a strategy that targets females for sterilization with vaccination outperforms all other options with respect to population control and demographic changes.
A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: A randomized, double-blinded, placebo-controlled clinical trial
Authors: samiraninezhad nazafarin , Rezaee Mostafa , Gholami Ahmad , Amanati Ali , Mardani Maryam 
Published: July 2023

Abstract
Objectives
Considering the prevalence of oral mucositis, we aimed to use the analgesic effects of doxepin with antimicrobial and bio-adhesive nature of chitosan to fabricate a nano-formulation for treatment of chemotherapy-induced oral mucositis.
Materials and Method
Nanogel was fabricated via ionic gelation and characterized. Sixty patients were randomly divided and received four different treatments for 14 days: diphenhydramine + aluminum-magnesium mouthwash (control), doxepin mouthwash (DOX MW), chitosan nanogel (CN), and doxepin/chitosan nanogel (CN + DOX). Lesions were assessed with four indices, national cancer institute (NCI), world health organization (WHO), and corld conference on clinical and research in nursing (WCCNR) and visual analogue scale (VAS) before and 3, 7, and 14 days after interventions. Kruskal Wallis test was used for pairwise comparison.
Results
CN had semisolid consistency, uniform spherical shape, an average size of 47.93 ± 21.69 nm and a zeta potential of + 1.02 ± 0.16 mV. Three days after intervention CN + DOX reduced WHO, WCCNR and VAS scores significantly more than control. Seven days after intervention CN + DOX reduced NCI and WCCNR significantly more than control; and it reduced WCCNR significantly more than CN. Fourteen days after intervention CN + DOX reduced NCI significantly more than control.
Conclusion
Chitosan-based doxepin nano-formulation might be a promising alternative for routine treatments of oral mucositis.
Leader-Follower Formation Tracking for Differential-Drive Wheeled Mobile Robots with Uncertainties and Disturbances based on Immune Fuzzy Quasi-Sliding Mode Control
Authors: Goto Willy John Nakamura , Martins Nardênio 
Published: July 2023

Abstract
Mobile robotics has drawn attention of researchers due to its variety of applications. In this paper, for nonholonomic differential-drive wheeled mobile robots with an embedded PD dynamic controller, a robust kinematic controller based on sliding mode theory is designed considering the trajectory tracking problem and its extension to the formation control by multiple robots using the leader-follower separation-bearing strategy. A classical sliding mode control has some drawbacks such as the chattering phenomenon and the requirement of a priori knowledge of the disturbances effects boundary for its design. Thus, this paper aims to propose the design of an approach inspired by an immune regulation mechanism, also using a simple fuzzy boundary layer method, in replacement of the discontinuous portion of the controller, adjusting its gains with no need to know the uncertainties and disturbances boundaries as well as suppressing the chattering. The effectiveness of the proposed controller is shown by simulation results and its stability is proved by the Lyapunov theorem.
Decreasing hospitalizations through geriatric hotlines: A prospective French multicenter study of people aged 75 and above
Authors: Goethals Luc , Barth Nathalie , Martinez Laure , Lacour Noémie , Tardy Magali , Bohatier Jérôme , Bonnefoy Marc , Annweiler Cédric , Dupre Caroline , Bongue Bienvenu , Celarier Thomas 
Published: July 2023

Abstract
Background
The Emergency unit of the hospital (Department) (ED) is the fastest and most common way for most French general practitioners (GPs) to respond to the complexity of managing older adults patients with multiple chronic diseases. In 2013, French regional health authorities proposed to set up telephone hotlines to promote interactions between GP clinics and hospitals. The main objective of our study was to analyze whether the hotlines and solutions proposed by the responding geriatrician reduced the number of hospital admissions, and more specifically the number of emergency room admissions
Methods
We conducted a multicenter observational study from April 2018 to April 2020 at seven French investigative sites. A questionnaire was completed by all hotline physicians after each call.
Results
The study population consisted of 4,137 individuals who met the inclusion and exclusion criteria. Of the 4,137 phone calls received by the participants, 64.2% (n = 2 657) were requests for advice, and 35.8% (n = 1,480) were requests for emergency hospitalization. Of the 1,480 phone calls for emergency hospitalization, 285 calls resulted in hospital admission in the emergency room (19.3%), and 658 calls in the geriatric short stay (44.5%). Of the 2,657 calls for advice/consultation/delayed hospitalization, 9.7% were also duplicated by emergency hospital admission.
Conclusion
This study revealed the value of hotlines in guiding the care of older adults. The results showed the potential effectiveness of hotlines in preventing unnecessary hospital admissions or in identifying cases requiring hospital admission in the emergency room. Hotlines can help improve the care pathway for older adults and pave the way for future progress.
Trial registration
Registered under Clinical Trial Number NCT03959475. This study was approved and peer-reviewed by the Ethics Committee for the Protection of Persons of Sud Est V of Grenoble University Hospital Center (registered under 18-CETA-01 No.ID RCB 2018-A00609-46).
Body Mass Index and Perceived Labor Control: Could weight stigma explain differences in birth experience?
Authors: Whelan Anna R , Polnaszek Brock E , Recabo Olivia , Clark Melissa A , Lewkowtiz Adam K , Ayala Nina K 
Published: July 2023

Abstract
Background
Individuals with a body mass index (BMI) of ≥ 30 kg/m2 experience weight stigma when interacting with the healthcare system. There is limited data on how weight stigma impacts patient’s experience of obstetric care. This study aims to assess perceived control over the birth process and compare patients with BMI ≥ 30 to those with BMI < 30.
Methods
We performed a secondary analysis of a cross-sectional study of term patients. Postpartum, participants completed the Labour Agentry Scale (LAS), a validated tool to assess perceived control over labor/birth. Continuous LAS scores were compared between patients with BMI < 30 and BMI ≥ 30.
Results
There was no difference in LAS between those with BMI ≥ 30 and BMI < 30. When stratified by World Health Organization (WHO) class of BMI, those with BMI ≥ 40 had a significantly lower LAS scores than those with BMI < 30 (147 vs. 163, p = 0.02), however, this finding was no longer significant after controlling for length of labor and cesarean birth.
Conclusion
Only participants with the highest BMI experienced decreased control over labor, and this finding was no longer significant after controlling for mode of delivery and length of labor. Further research is necessary into how weight stigma influences birthing people’s experience.
Accuracy of automated computer-aided risk scoring systems to estimate the risk of COVID-19: a retrospective cohort study
Authors: Faisal Muhammad , Mohammed Mohammed Amin , Richardson Donald , Fiori Massimo , Beatson Kevin 
Published: July 2023

Abstract

Background: In the UK National Health Service (NHS), the patient’s vital signs are monitored and summarised into a National Early Warning Score (NEWS) score. A set of computer-aided risk scoring systems (CARSS) was developed and validated for predicting in-hospital mortality and sepsis in unplanned admission to hospital using NEWS and routine blood tests results. We sought to assess the accuracy of these models to predict the risk of COVID-19 in unplanned admisisons during the first phase of the pandemic.
Methods: Adult (>=18 years) non-elective admissions discharged (alive/deceased) between 11-March-2020 to 13-June-2020 from two acute hospitals with an index NEWS electronically recorded within ±24 hours of admission. We identified COVID-19 admission based on ICD-10 code ‘U071’ which was determined by COVID-19 swab test results (hospital or community). We assessed the performance of CARSS (CARS_N, CARS_NB, CARM_N, CARM_NB) for predicting the risk of COVID-19 in terms of discrimination (c-statistic) and calibration (graphically).
Results: The risk of in-hospital mortality following emergency medical admission was 8.4% (500/6444) and 9.6% (620/6444) had a diagnosis of COVID-19. For predicting COVID-19 admissions, the CARS_N model had the highest discrimination 0.73 (0.71 to 0.75) and calibration slope 0.81 (0.72 to 0.89) compared to other CARSS models: CARM_N (discrimination:0.68 (0.66 to 0.70) and calibration slope 0.47 (0.41 to 0.54)), CARM_NB (discrimination:0.68 (0.65 to 0.70) and calibration slope 0.37 (0.31 to 0.43)), and CARS_NB (discrimination:0.68 (0.66 to 0.70) and calibration slope 0.56 (0.47 to 0.64)).
Conclusions: The CARS_N model is reasonably accurate for predicting the risk of COVID-19. It may be clinically useful as an early warning system at the time of admission especially to triage large numbers of unplanned hospital admissions because requires no additional data collection and is readily automated.
Overexpression of OsHSP 18.0 in rice enhance tolerance to heavy metal stress
Authors: Tseng Tong-Seung , Rajendran Senthil Kumar , Liu Yi-Hsin , Wu Shaw-Jye , Lu Chung-An , Yeh Ching-Hui 
Published: July 2023

Abstract
Plants synthesis multiple families of sHSPs with monomer sizes ranging from 12 to 42 kDa, are the most diverse and more abundant than in other organisms (Wu et al., 2022). In addition to heat tolerance, the sHSPs suggesting that they may play important roles other cellular processes under normal conditions (Wu et al., 2022). Over the past decades, it has been observed that the expression of certain plant sHSPs is induced by a range of stressors, including heat, salt, drought, osmotic, hormonal, heavy metal, oxidative stresses, as well as developmental signals specific to plants (Wu, et al. 2022). In addition, a multitude of investigation have involved the overexpression of various sHSPs in both homologous and heterologous plant systems, including E. coli and Yeast models (Santhanagopalan, et al. 2015; Waters and Vierling 2020). The outcomes of many of these experiments have revealed that stress protection conferred by these proteins is restricted to specific conditions and narrow range of plant growth stages. On contrast, suppression of CI or CII sHSPs in A. thaliana by RNAi showed that these sHSPs were required for recovery from a severe heat stress (10 h at 45°C) and have independent functions (McLoughlin, et al. 2016; Wu, et al. 2022). However, additional investigations are needed to uncover further applications for these proteins.
Histofarcin Skin Test and an In-Vitro Antifungal Effects of Croton Macrostachyus against Mycelial Form of Histoplasma capsulatum Variety Farciminosum isolated from Horse in Adama City, Ethiopia
Authors: Tegegne Hailehizeb , Woldegiorgis Dese 
Published: July 2023

Abstract
Background: Epizootic Lymphangitis (EL) is a chronic debilitating disease of equines caused by Histoplasma capsulatum variety farciminosum (HCF). It is one of the major equine diseases with economics and equines welfare consequences. An experimental study design was conducted from Nov, 2021 to June, 2022 to assess the histofarcin skin test and evaluate the antifungal efficacy of Croton macrostachyus against the mycelium form of HCF. The histofarcin antigen used for histofarcin skin test was prepared from field isolates of HCF, identified from clinical cases of EL in cart horses from Adama City.
Result: Then, histofarcin skin test was evaluated on 60 horses, 15 clinically infected cases, and 45 healthy horses. Each horse was injected with 0.1ml of the histofarcin skin test antigen intradermally in the middle of the neck. The thickness of the skin was measured before the injection and 24 hrs post injection using Bar Knight Mc Lintock(McLK)-P0005) caliper. The sensitivity and specificity of histofarcin skin test were 100% and 95% respectively. An in vitro growth inhibitory effect of Croton macrostachyus against the mycelia form of HCF was evaluated. Two-fold serial dilutions of the methanol extracts of the plant were prepared and assessed. A culture media with no antifungal agent and media containing ketoconazole served as a negative and positive control, respectively.
Conclusion:The results showed that Croton macrostachyus have an inhibitory effect at concentrations ranging from 2.5mg/ml–10mg/ml. Thus, the minimum inhibitory concentration of the plant extract was found to be 2.5mg/ml. In conclusion, this study demonstrated that histofarcin skin test is a potential diagnostic tool for screening EL. Also, the methanol extracts of Croton macrostachyus showed good in-vitro growth inhibitory activity against the mycelial phase of HCF. Therefore, Validation of the performance of the histofarcin skin test assessment is necessary. Also, further investigation of the effects of C. macrostachyus on the yeast form of HCF is needed in addition to Phytochemial analysis (fractionation) and evaluation of the toxicity of the plant.
Behavioral Activity and Ranging Patterns of the Endemic Gelada Monkey (Theropithecus gelada) in and Around Jer Silase Monastry in North Shoa Zone, Ethiopia
Authors: Desalegn Tamenut 
Published: July 2023

AbstractThe study aimed to investigate the activity, ranging patterns, and habitat use of gelada monkeys. Understanding of behavioral ecology of primates in Jer Silase Monastery is crucial to their conservation and monitoring strategies. The study was carried out from January 2021 to October 2021 by considering both dry and wet seasons and by stratifying the study area as natural forest, cliff/rocky, and farmland. The instantaneous scan sampling method was employed to collect behavioral data. The activity pattern of three selected focal groups of geladas was studied, and predominant behavioral activities recorded GPS points every 15-minute intervals from beginning 7:00 h to dusk at 18:00 hr for 12 days per month. Mann-Whitney U test was employed to compare the seasonal variation of the behavioral activity patterns of geladas in the wet and dry seasons. A chi-square test (c2) of independence was also employed to examine the gelada monkeys’ behavior differently in different habitat types. Home range and day range length were determined by using Open Jump Toolbox (MOVEAN), and statistically tested by Mann–Whitney U test. A total of 5592 individual activity records were obtained during 2312 scan sampling on 120 study days. Feeding comprised 54.52% of the total scan, followed by moving 20.67% and socialization 11.95%. Habitat utilization of the gelada monkey in the three habitat types has a statistically significant difference (χ2 = 329.13, df = 2, p = 0.004). The result of multivariate analysis demonstrated that month has a statistically significant effect on an activity time budget Roy’s Largest Root = 2.7, F = 13.2, df = 4, p < 001, partial η2 = 0.653. The highest mean monthly travel distance of the focal group over the entire course of gelada recorded at the Cliff/rocky habitat was 2817.61 ± 582.57 m during the wet season. Geladas travel a longer daily range length and cover a wider home range size in the dry season. This shows the quality of the habitat is decreasing due to livestock grazing, agricultural expansion, and charcoal production. Therefore, to minimize such effects on gelada monkeys’ appropriate conservation measures should be implemented to conserve the gelada baboon.