bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical manifestations and vision-related quality of life in pediatric uveitis
Authors: Li Yiran , Yang Liu 
Published: May 2023

Purpose:
To analyze clinical manifestations, visual ability, and quality of life in pediatric uveitis and to explore factors affecting visual ability and quality of life.

Methods:
This cross-sectional study included 40 patients with pediatric uveitis in the database of Ophthalmology of Peking University First Hospital. All patients completed the Cardiff visual ability questionnaire for children (CVAQC) and pediatric quality of life inventory measurement models (PedsQL4.0).

Results:
A total of 40 cases (68 eyes) with pediatric uveitis were included in this study. Better visual acuity in the better eye was predictive of lower CVAQC, education, and distance vision scores. Better visual acuity in the worse eye was predictive of a lower CVAQC score and distance vision. Better CVAQC scores were predictive of lower PedsQL4.0, physical health, psychosocial health, and school functioning scores.

Conclusion:
Patients with pediatric uveitis tend to be seriously affected by ocular complications. The visual ability of patients with pediatric uveitis decreases significantly. Better visual acuity in the better eye is associated with better total visual ability, education, and distance vision. Better visual acuity in the worse eye is associated with better total visual ability and distance vision. Health-related quality of life is related to vision ability in pediatric uveitis.
Incidence, clinical features, risk factors, and outcomes of Intraocular inflammation following Brolucizumab in Indian eyes – A multicentric study
Authors: Chakraborty Debdulal , Mondal Soumen , Sengupta Sabyasachi , Abbas Zahir , Chandra Khushboo , Boral Subhendu , Maiti Aniruddha , Roy Sangeeta , Mukherjee Angshuman , Das Arnab , Chakraborty Somnath , Nag Pinaki 
Published: May 2023

Purpose:
To report the incidence, clinical features, potential risk factors, and outcomes of intraocular inflammation (IOI) following brolucizumab in Indian eyes.

Methods:
All consecutive patients diagnosed with brolucizumab-induced IOI from 10 centers in eastern India between October 2020 and April 2022 were included.

Results:
Of 758 injections given during the study period across centers, 13 IOI events (1.7%) were recorded attributable to brolucizumab. The IOI occurred after the first dose in two eyes (15%) (median 45 days after brolucizumab), second dose in six eyes (46%) (median = 8.5 days), and third dose (39%) in the remaining five eyes (median 7 days). Reinjections of brolucizumab were administered at a median interval of 6 weeks (interquartile range = 4–10 weeks) in the 11 eyes, where IOI occurred after the second or third dose. Eyes that experienced IOI after the third dose had received a significantly greater number of previous antivascular endothelial growth factor injections (median = 8) compared to those who developed it after the first or second dose (median = 4) (P = 0.001). Anterior chamber cells were seen in almost all eyes (n = 11, 85%), while peripheral retinal hemorrhages were seen in two eyes, and one eye showed branch artery occlusion. Two-thirds of patients (n = 8, 62%) recovered with a combination of topical and oral steroids, while remaining recovered with topical steroids alone. Irreversible visual loss was not seen in any eye, and median vision recovered to pre-IOI levels by 3 months’ time point.

Conclusion:
Brolucizumab-induced IOI was relatively rare, occurring in 1.7% of eyes, was more common after the second or third injection, especially in those who required frequent reinjections every 6 weeks, and occurred earlier with increasing number of previous brolucizumab injections. Continued surveillance is necessary even after repeated doses of brolucizumab.
Bibliometric analysis of pediatric glaucoma
Authors: Jain Divya , Dhua Anjan Kumar 
Published: May 2023

Purpose:
The research activity in pediatric glaucoma (PG) was qualitatively and quantitatively evaluated using a scientometric approach.

Methods:
The “Web of Science” database was accessed for primary bibliometric data regarding PG using search terms “pediatric glaucoma,” “paediatric glaucoma,” “congenital glaucoma,” and “childhood glaucoma.” The data was analyzed for total research productivity, citations, and scientific output in terms of journals, countries, institutions, and authors. The results were further characterized for coauthorship links and visualized by VOS viewer software. Also, the top 25 cited articles were reviewed with the above bibliometric characteristics.

Results:
One thousand two hundred and sixty-nine items were obtained from our search query from 1955 to 2022; these received 15,485 citations, originated from 78 countries. The top-3 contributing countries were the United States of America (n = 369), India (n = 134), and China (n = 127). LV Prasad Eye Institute (n = 58), Duke University (n = 44), and King Khalid Eye Specialist Hospital (n = 42) were the top-3 productive institutes. The top-3 prolific authors were Mandal AK (n = 53), Freedman, SF (n = 36), and Sarfarazi, M (n = 33). Journal wise, “Investigative Ophthalmology” (n = 187), “Journal of Glaucoma” (n = 92), and “Journal of AAPOS” (n = 68) were the journals in which the most articles were published. The top-25 cited documents received 3564 citations and were published between 1977 and 2016. The key areas of interest were basic sciences (genetics of childhood glaucoma) and surgical management.

Conclusion:
United States of America, LVPEI, Mandal AK, and “Investigative Ophthalmology” were the top rankers as far as the productivity and publications related to PG are concerned. Articles on molecular genetics in PG have received interest among the ophthalmology community.
Visual outcomes of early enhancement following small incision lenticule extraction versus laser in situ keratomileusis
Authors: Soundarya B , Sachdev Gitansha Shreyas , Ramamurthy Shreyas , Kumar Shreesha K , Dandapani Ramamurthy 
Published: May 2023

Purpose:
To compare visual outcomes of early enhancement following small incision lenticule extraction (SMILE) versus laser in situ keratomileusis (LASIK).

Methods:
Retrospective analysis of eyes (patients operated in the setting of a tertiary eye care hospital between 2014 and 2020) requiring early enhancement (within one year of primary surgery) was conducted. Stability of refractive error, corneal tomography, and anterior segment Optical Coherence Tomography (AS-OCT) for epithelial thickness was performed. The correction post regression was done using photorefractive keratectomy and flap lift in eyes, wherein the primary procedure was SMILE and LASIK, respectively. Pre- and post enhancement corrected and uncorrected distance visual acuity (CDVA and UDVA), mean refractive spherical equivalent (MRSE), and cylinder were analyzed. IBM SPSS statistical software.

Results:
In total, 6350 and 8176 eyes post SMILE and LASIK, respectively, were analyzed. Of these, 32 eyes of 26 patients (0.5%) post SMILE and 36 eyes of 32 patients (0.44%) post-LASIK required enhancement. Post enhancement (flap lift in LASIK, and PRK in SMILE group) UDVA was logMAR 0.02 ± 0.05 and 0.09 ± 0.16 (P = 0.009), respectively. There was no significant difference between the refractive sphere (P = 0.33) and MRSE (P = 0.09). In total, 62.5% of the eyes in the SMILE group and 80.5% in the LASIK group had a UDVA of 20/20 or better (P = 0.04).

Conclusion:
PRK post SMILE demonstrated comparable results to flap lift post LASIK and is a safe and effective approach for early enhancement post SMILE.
Imaging iridotrabecular contact in angle closure
Authors: Mansoori Tarannum 
Published: May 2023

Background:
With ultrasound biomicroscopy (UBM), radial scans are taken by using a typical ciliary process, to show the details of the iridocorneal angle, the anterior surface of the ciliary body, and its relation to the posterior iris. Appositional closure represents potentially reversible contact between the peripheral iris and trabecular meshwork. The appositional closure can further be classified according to the configuration of iridotrabecular contact (ITC). UBM can be performed in dark and light conditions, which has been shown to be useful for detecting changes in iridocorneal angle configuration associated with dark and light.

Purpose:
To image ITC configuration in appositional angle closure and also image iridocorneal angle in dark and bright light room illumination.

Synopsis:
UBM demonstrates two types of ITC configuration in appositional closure which are, B-type and S-type. It can also demonstrate the presence of sinus of Mapstone in S-type of ITC.

Highlights:
UBM allows imaging of dynamic changes in the iris and shows that the degree of appositional angle closure is a dynamic process that can change rapidly depending on the lighting conditions.

Video link:
https://youtu.be/tgN4SLyx6wQ.

Key words: Appositional angle closure, B and S type appositional closure, dark- light condition, ultrasound biomicroscopy
PERANAN KUALITAS PELAYANAN DALAM MENINGKATKAN KEPUASAN PELANGGAN PADA DINAS PENCEGAH DAN PEMADAM KEBAKARAN KOTA MEDAN
Authors: Sitio Fandi Winata , Hutapea Tito Santana 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui Peranan Kualitas Pelayanan dalam Meningkatkan Kepuasan Pelanggan pada Dinas Pencegah dan Pemadam kebakaran Kota Medan. Metode analisis data yang digunakan yaitu dengan metode deskriptif dan deduktif, Berdasarkan hasil pembahasan yang dilakukan maka dapat disimpulkan bahwa pelayanan yang telah diberikan oleh petugas pemadam kebakaran telah berjalan dengan baik dimana dalam melaksanakan pelayanan publik berdasarkan dimensi pelayanan yaitu sikap petugas, prosedur, waktu fasilitas dan pelayanan. Faktor-faktor yang mempengaruhi indeks kepuasan masyarakat pada seksi Pencegah dan Pemadam Kebakaran Kota Medan yaitu Sumber Daya Manusia yaitu kemampuan petugas pemadam kebakaran dalam melaksakan tugas sangat baik, ini dikarenakan para petugas telah mengikuti pelatihan tentang pencegahan dan pemadam kebakaran dan Sarana Prasarana. Dan penulis menyarankan supaya instansi terus mengembangkan kualitas pelayanan publik terhadap masyarakat kota Medan dan untuk peneliti selanjutnya sebaiknya ditambahkan faktor-faktor lainnya yang dapat mengembangkan peranan kualitas pelayanan bagi masyarakat.
PENGARUH PERPUTARAN MODAL KERJA TERHADAP CURRENT RASIO PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Zai Nirmawati , Sinaga Erni 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui pengaruh perputaran modal kerja terhadap current ratio pada perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia periode 2017-2019. Rumusan masalah penelitian yaitu apakah perputaran modal kerja berpengaruh terhadap current ratio dimana populasi penelitian adalah sebanyak 37 perusahaan teknik pengambilan sampel dilakukan berdasarkan teknik purposive sampling sesuai dengan kriteria yang ditentukan, sampel dalam penelitian adalah sebanyak 16 Perusahaan. Berdasarkan hasil pengujian hipotesis dapat disimpulkan: nilai signifikan uji-t Perputaran Modal Kerja = 0,806 > 0,05 atau nilai sebesar -0,251 < t tabel = 2,145 (α = 0,05/2; n-k-1), artinya bahwa H0 diterima dan Ha ditolak. Hasil uji regresi linear sederhana Y = 887,154 - 0,002 X, pada analisis koefisien determinasi atau R Square sebesar 0,004 dimana hasil ini dapat dijelaskan bahwa Perputaran Modal Kerja memberikan pengaruh terhadap Current Ratio (Y) sebesar 0,4% sedangkan sisanya adalah sebesar 99,996% dipengaruhi oleh faktor lain. Saran sebaiknya penelitian yang akan datang meneliti semua jenis perusahaan yang terdaftar di Bursa Efek Indonesia dengan pengamatan yang lebih panjang atau meneliti variabel lain yang mempengaruhi current ratio seperti perputaran kas, perputaran persediaan dan perputaran piutang.
PENGARUH MEREK TERHADAP PROSES KEPUTUSAN PEMBELIAN PRODUK DI PT. SUAN BAKERY MEDAN
Authors: Halawa Hendisman , Br Sinulingga Nuriyanti Febrina 
Published: May 2023

Merek merupakan suatu nama, simbol tanda desain atau gabungan diantaranya untuk dipakai sebagai identitas suatu perorangan, organisasi atau perusahaan pada barang dan jasa yang dimiliki untuk membedakan dengan produk jasa lainnya. Rumusan masalah dalam penelitian ini adalah apakah merek berpengaruh terhadap proses keputusan pembelian produk di PT. Suan Bakery Medan. Tujuan dari penelitian ini untuk mengetahui pengaruh merek terhadap proses keputusan pembelian di PT. Suan Bakery Medan. Hipotesis dalam penelitian ini adalah merek berpengaruh terhadap proses keputusan pembelian produk di PT.Suan Bakery. Penelitian ini menggunakan analisis uji regresi linear sederhana, uji determinasi, uji t. Jumlah sampel dalam penelitian ini adalah 82. Hasil penelitian menjawab rumusan masalah yaitu ada Pengaruh Aspek Merek Terhadap Proses Keputusan Pembelian Produk Di PT. Suan Bakery. Penelitian ini menunjukkan persamaan regresi dimana Y= 2,595+ 0,566 X yang artinya aspek merek memiliki pengaruh yang positif terhadap minat keputusan konsumen.

Dari hasil penelitian yang dilakukan diketahui hasil uji t dimana thitung = 8,767 sedangkan nilai ttabel =0,67757 sehingga thitung>ttabel yang artinya jika merek ditingkatkan maka minat konsumen juga akan meningkat. Maka kesimpulan dari penelitian ini adalah dari hasil uji koefisien determinasi pada R Sguare sebesar 0,490 hal ini menunjukkan bahwa minat beli konsumen 49% dipengaruhi oleh aspek merek dan sisanya 51% dipengaruhi oleh variabel lain diluar penelitian ini. Saran dari penelitian ini adalah akan lebih baik lagi jika aspek merek terus diterapkan dan ditigkatkan dengan disertai meningkatnya minat konsumen, karena karyawan PT. Suan Bakery akan memiliki peluang untuk menyalurkan kreativitasnya dengan ide merek yang lebih baik.
Բանաստեղծ գրականագետը (Վահագն Դավթյան – 100)
Authors: Քալանթարյան Ժենյա 
Published: May 2023

Հոդ­վա­ծում քննութ­յան են առն­վում Վա­հագն Դավթ­յա­նի գրա­կան-քննա­դա­տա­կան հոդ­ված­նե­րը, ո­րոնք վե­րա­բե­րում են հայ և տար­բեր ազ­գե­րի գրող­նե­րի (բա­նաս­տեղծ­նե­րի) և պա­րու­նա­կում են ընդ­հան­րա­կան նշա­նա­կութ­յուն ու­նե­ցող տե­սա­կան հար­ցադ­րում­ներ։ Այդ հար­ցա­դրում­նե­րը վե­րա­բե­րում են պոե­զիա­յի էութ­յա­նը, ա­վան­դույ­թի և նո­րա­րա­րութ­յան անխ­զե­լի կա­պին, գրա­կա­նութ­յան ազ­գա­յին բնույ­թին, թարգ­մա­նութ­յան խնդրին և­ այլն։ Դավթ­յա­նի հոդ­ված­նե­րը երկպ­լան են, ո­րով­հետև մի կող­մից բա­ցա­հայ­տում են ան­հատ գրո­ղի ա­ռան­ձնա­հա­տուկ կող­մե­րը, մյուս կող­մից՝ գրա­կա­նութ­յան ընդ­հա­նուր օ­րի­նա­չա­փութ­յուն­նե­րը։
Դավթ­յա­նի գրա­կա­նա­գի­տա­կան հոդ­ված­նե­րի հետ սեր­տո­րեն առնչ­վում են ընդ­հան­րա­պես մշա­կույ­թի և­ ար­վես­տի տար­բեր ճյու­ղե­րի՝ նկար­չութ­յան, ե­րաժշ­տութ­յան, թատ­րո­նի ու ռե­ժի­սու­րա­յի, ճար­տա­րա­պե­տութ­յան ու քան­դա­կա­գոր­ծութ­յան վաս­տա­կա­շատ գոր­ծիչ­նե­րի դի­ման­կար­նե­րը՝ նրանց ար­վես­տի՝ նրբո­րեն դիտ­ված հատ­կա­նիշ­նե­րի ընդգծ­մամբ։ Ն­մա­նա­տիպ հոդ­ված­նե­րը հա­կա­դարձ է­ֆեկ­տով ստեղ­ծում են հենց Դավթ­յան ար­վես­տա­գե­տի դի­ման­կա­րը։
Role of Pathya-Apathya in the Management of Prameha (Type-2 Diabetes Mellitus)
Authors: Mohit Sharma  , Prem Prakash Vyas  , Harish Kumar Singhal  
Published: May 2023

Before starting management of any disease three important things to be kept in mind that is etiology, well planning, and Pathya-Apathya. Pathya–Apathya plays important role in the management of various disorders. Prameha is one of such disorder in which Pathya-Apathya affect its morbidity. Etiology, etiopathogenesis with clinical manifestation of Prameha are very well described in ancient textbook like Charaka Samhita, Sushruta Samhita, Astanga Hridyam and Astanga Samgraha etc. In all treatise of Ayurveda, Prameha is considered as Santarpanajanya Vikara that is of three types i.e., Vataj, Pittaj and Kaphaja. Madhumeha mentioned under the heading of Vataj Prameha that is closely correlated to diabetes mellitus. Diabetes Mellitus is of two type viz., Type-1 Diabetes & Type-2 Diabetes. Among that, Type-2 diabetes is non-insulin dependent diabetes mellitus that occur in middle age. In this clinical entity insulin resistance was developed. In its management, Pathya–Apathya contributes a major role in controlling blood sugar level. Therefore, author attempted to highlight role of Pathya–Apathya (do’s & don’t) in the management of Type-2 Diabetes Mellitus.
Overview of gait rehabilitation in stroke
Authors: Sana Khalid  , Arshad Nawaz Malik  , Furqan Ahmed Siddiqi  , Farooq Azam Rathore  
Published: May 2023

Stroke is the 2nd leading cause of death globally after ischaemic heart disease and is expected to rise more by 2030. The estimated incidence of stroke in Pakistan is about 250/100,000 individuals. Difficulty in walking is present in approximately 80% of stroke survivors. About a quarter of stroke survivors, even after receiving rehabilitation have residual gait impairments requiring assistance in activities of daily life. Almost half of stroke patients after being discharged will have episodes of fall, with majority of these falls occurring in activities like “turning”. Gait is one of the key features to participate in community and occupational activities. Therefore, appropriate gait rehabilitation post stroke is crucial for functional independence and community ambulation. There are many approaches to gait rehabilitation based on different models of motor physiology and disease. Augmenting conventional therapies with novel techniques such as utilization of electromechanical means have improved gait rehabilitation in improving functions. The usage of technology in rehabilitation of patients with neurological deficits, is still novel in Pakistan. This review provides an overview of advancements in neurological and gait rehabilitation post stroke.
Keywords: Cerebrovascular accident, gait, muscle strength, rehabilitation, robotics, virtual reality.
Tirzepatide (Mounjaro) - a novel Pharmacotherapeutic Agent for Obesity
Authors: Khatri Tayyaba , Siddiqui Tasmiyah , Doultani Payal Rani 
Published: May 2023

Obesity and its consequential morbidities are a major global burden. with Pakistan having a national obesity risk of 6.5/10.(1) Raised BMI (body mass index-an index of weight to height ratio) along with obesity is one the prime risk factors that lead to numerous other non-transmissible diseases like heart diseases, Type 2 diabetes, osteoarthritis and certain carcinomas (Breast, ovarian, colon, liver, prostate, gall bladder). Lifestyle interventions can only produce modest (~5-10%) weight loss, necessitating other antiobesity interventions. Therefore, pharmacological approaches to losing weight are in the limelight. The U.S. (FDA) Food and Drug Administration has also authorized pharmacological treatment as a new treatment option to incorporate into weight management programme with concomitant dietary and physical behavioral remodeling in patients having 27 kg/m2 or higher BMI along with incidence of any of the following obesity-related comorbidities: T2DM, hypertension, or hypercholesterolemia (2).As of 2021 around 5 antiobesity medications (AOMs) have been approved by FDA so far but a recent randomized, placebo controlled double blind trial has incredibly unveiled the potential effects of tirzepatide as an antiobesity drug.
Tirzepatide (Mounjaro) is an exclusive and the only dual receptor agonist the mimicking actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) and therefore referred as “twincretin”. This drug, originally used to treat T2DM, has now been incredibly effective in treating obesity. According to a recent randomized control trial, 85% of participants with a 5.0 mg dose, 89% participants with a 10 mg dose and 91% participants with a 15 mg dose showed a significant reduction in weight(3) which is a corroborating evidence supporting tirzepatide as antiobesity drug. According to SURPASS-2 clinical trial, comparing efficacy of tirzepatide to semaglutide (a selective GLP-1 receptor agonist), tirzepatide was proven to reduce body weight and A1C levels more effectively than semaglutide demonstrating it to be better in treating not only diabetes but obesity(4). The SURMOUNT-1 trial, depicting the efficacy of tirzepatide, showed significant weight reduction of up to 22.5 % in obese adults (5)
Some of the adverse effects noted with its use were gastrointestinal events like nausea, vomiting and diarrhea. A few contraindications are gallbladder disease, pancreatitis, genetic predisposition of medullary thyroid carcinoma and MEN (multiple endocrine neoplasia) Type 2.
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Carmina. Livre VI
Authors: de L'Hospital Michel 
Published: May 2023

Le livre VI des Carmina de Michel de L’Hospital comprend treize épîtres hexamétriques composées entre 1562 et 1572, soit du début des guerres de religion au seuil de la Saint-Barthélemy. Deux épîtres sont adressées au cardinal de Lorraine et marquent la fin de la relation entre les deux hommes ; huit autres sont adressées à des serviteurs du roi (De Thou, Pibrac, Du Ferrier, Du Faur), à des juristes (Vacca) et à des philologues (Turnèbe, Corbinelli) ; enfin, trois sont dépourvues de destinataire précis. L’Hospital développe de profondes réflexions politiques, philosophiques, littéraires et religieuses. En sage observateur de son époque, dont il déplore les vices, il laisse une place de plus en plus ample à son idéal éthique et évangélique. La disgrâce du chancelier en 1568 nourrit une méditation sur la vieillesse et le salut. La mise en scène de la violence, physique ou verbale, offre au lecteur un miroir pour notre temps. L’édition fournit le texte latin établi sur les manuscrits collationnés avec les éditions imprimées de 1558 et 1732, une nouvelle traduction, en stiques, une présentation du contexte, une analyse et un commentaire. Le volume est complété d’une introduction, d’un index des lieux, des personnes et des matières.
Effects of New Agri Techniques on World Hunger
Authors: Mukasa James 
Published: May 2023

Purpose: The aim of the study was to examine the effect of new agriculture techniques on world hunger.
Methodology: This study adopted a desktop methodology. This study used secondary data from which include review of existing literature from already published studies and reports that was easily accessed through online journals and libraries.
Findings: The study revealed that new agri techniques has increased yield of crops. With advanced technology and modern crop varieties, farmers can produce more food with less land, water, and other resources. This can help to meet the growing demand for food as the global population continues to increase. Some of the new agri technique include adoption of GMOs, precision irrigation, precision agriculture and vertical farming.
Unique Contribution to Theory, Practice and Policy: The study was anchored theory of sustainable agriculture and theory of agricultural innovation systems (AIS). The study recommended that policies and institutional frameworks should be developed to support the adoption of modern technologies in agriculture including the provision of technical assistance, access to credit and market support. The study recommended there is need for financial incentives to encourage farmers to adopt new agricultural techniques.