bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating biomedical research literature in the blogosphere: a case study of diabetes and glycated hemoglobin (HbA1c)
Authors: Gruzd Anatoliy , Black Fiona A. , Le Thi Ngoc Yen , Amos Kathleen 
Published: February 2023

<p>Objective: The research investigated the relationship between biomedical literature and blogosphere discussions about diabetes in order to explore the role of Web 2.0 technologies in disseminating health information. Are blogs that cite biomedical literature perceived as more trustworthy in the blogosphere, as measured by their popularity and interconnections with other blogs? </p>
<p>Methods: Web mining, social network analysis, and content analysis were used to analyze a large sample of blogs to determine how often biomedical literature is referenced in blogs on diabetes and how these blogs interconnect with others in the health blogosphere. </p>
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<p>Results: Approximately 10% of the 3,005 blogs analyzed cite at least 1 article from the dataset of 2,246 articles. The most influential blogs, as measured by in- links, are written by diabetes patients and tend not to cite biomedical literature. In general, blogs that do not cite biomedical literature tend not to link to blogs that do. </p>
<p>Conclusions: There is a large communication gap between health professional and personal diabetes blogs. Personal blogs do not tend to link to blogs by health professionals. Diabetes patients may be turning to the blogosphere for reasons other than authoritative information. They may be seeking emotional support and exchange of personal stories. </p>
Enabling Community Through Social Media
Authors: Gruzd Anatoliy , Haythornthwaite Caroline 
Published: February 2023

<p>Background: Social network analysis provides a perspective and method for inquiring into the structures that comprise online groups and communities. Traces from interaction via social media provide the opportunity for understanding how a community is formed and maintained online. </p>
<p>Objective: The paper aims to demonstrate how social network analysis provides a vocabulary and set of techniques for examining interaction patterns via social media. Using the case of the #hcsmca online discussion forum, this paper highlights what has been and can be gained by approaching online community from a social network perspective, as well as providing an inside look at the structure of the #hcsmca community. </p>
<p>Methods: Social network analysis was used to examine structures in a 1-month sample of Twitter messages with the hashtag #hcsmca (3871 tweets, 486 unique posters), which is the tag associated with the social media–supported group Health Care Social Media Canada. Network connections were considered present if the individual was mentioned, replied to, or had a post retweeted. </p>
<p>Results: Network analyses revealed patterns of interaction that characterized the community as comprising one component, with a set of core participants prominent in the network due to their connections with others. Analysis showed the social media health content providers were the most influential group based on in-degree centrality. However, there was no preferential attachment among people in the same professional group, indicating that the formation of connections among community members was not constrained by professional status. </p>
<p>Conclusions: Network analysis and visualizations provide techniques and a vocabulary for understanding online interaction, as well as insights that can help in understanding what, and who, comprises and sustains a network, and whether community emerges from a network of online interactions. </p>
Interval prediction of order statistics and record values using concomitants of order statistics and record values for Morgenstern family of distributions
Authors: Muraleedharan Laji , Chacko Manoj 
Published: February 2023

In this paper, we discuss the problem of predicting intervals for future order statistics and k-record values based on observed concomitants of order statistics and observed concomitants of k-record values arising from a Morgenstern family of distributions. The coverage probabilities obtained are accurate and independent of the parent distribution. A real data set is also considered to exemplify the proposed methodologies developed in this paper.
Journal of Statistical Research 2022, Vol. 56, No. 1, pp. 55-72
Implicancias del Programa Scratch en el proceso de aprendizaje: una revisión bibliográfica
Authors: Huaripata-Huaripata Angélica 
Published: February 2023

El reciente estudio tiene como fin indagar y analizar la información de investigaciones teóricas y empíricas sobre el Programa Scratch y su implicancia en el proceso de aprendizaje, por ello se han recopilado y analizado información relevante, teniendo como resultado la revisión de 45 investigaciones de los cuales se ha considerado 24 artículos científicos que se encuentran alineados al objetivo planteado. En los estudios revisados se utiliza como metodología la investigación bibliográfica documental y como instrumento la lectura crítica de antecedentes, teniendo en cuenta la referencia de estudios de los seis últimos años de publicación. En los resultados se instituyó la implicancia del Programa Scratch en el proceso de aprendizaje, por ello, es primordial el uso de software educativo en la labor docente, porque permite al profesor tener claro los propósitos de aprendizaje que busca, la forma más creativa para que los dicentes pueden alcanzar los estándares a lo largo de la actividad de aprendizaje. Se concluye que la aplicación del Programa Scratch ha evolucionado el ámbito educativo de forma óptima, cambiando las estrategias rutinarias del proceso de enseñar; por aquellas que favorecen en los escolares el desarrollo de habilidades tecnológicas.
Gestión del talento humano en el entorno BANI
Authors: Huicab-García Yhadira 
Published: February 2023

El entorno BANI (acrónimo de brittle, anxius, non-linear, incompreensivel, que traducido al español, es: frágil, ansioso, no lineal e incomprensible), se desarrolla a partir del año 2020, donde las personas, organizaciones y naciones se vieron afectadas por la pandemia sanitaria por diversos cambios en el entorno. El presente proyecto de investigación realiza un análisis en la gestión del talento humano en el entorno BANI para las organizaciones, en donde se investigan las estrategias centradas en la gestión y retención del talento humano a nivel operativo, que desarrollan las empresas en los momentos donde se genera un entorno quebradizo, inestable, ambiguo e incomprensible y se valida la prospectiva estratégica con la variable talento humano de la organización.
La metodología que se sigue es una investigación documental que permita analizar las tendencias de la gestión del talento humano y estudio de los entornos interno y externo, VICA y BANI, analizar estrategias que implementan muchas organizaciones para fidelizar el talento humano de la organización. La investigación documental es una técnica de investigación cualitativa, las técnicas utilizadas durante el proceso de investigación fueron los grupos focales, las entrevistas semi-estructuradas, encuestas para la caracterización poblacional y aplicación de una escala tipo Likert para tener el índice de calidad ambiental percibida, a través de un cuestionario estructurado, permitiendo estudiar la cultura organizacional o corporativa, liderazgo empresarial, responsabilidad social empresarial, productividad, gerencia del cambio, replantear la empresa en el corto plazo, riesgos, disrupción, adaptación a entornos VICA y BANI.
Una mirada a la educación ubicua, y su eventual interacción con los sistemas cognitivos
Authors: Rivadeneira-Ramos Edgar , Galarza-Schoenfeld Juan 
Published: February 2023

Este trabajo ha volcado su mirada a la necesidad de encontrar un nuevo posible escenario de lo que es la educación ubicua, haciendo que como parte de ese modelo se integre a los sistemas cognitivos, para orientar un entorno mucho más ajustado a las necesidades de los beneficiarios (estudiantes y profesores).
Se inicia analizando el efecto de la pandemia del COVID-19 en el sistema académico, sin dejar de considerar el hecho cierto de que la tecnología está presente en este ámbito desde hace mucho tiempo, pero las condiciones presentadas desde el primer trimestre del año 2020, ha hecho que este sea un tema de creciente relevancia.
La problemática se resume en el conflicto que poseen los alumnos universitarios, en cuanto a realizar las diligencias académicas en un ambiente on-line, al no poseer un modelo tecnológico que les brinde aptitudes para la elaboración de las actividades tomando en cuenta sus existentes necesidades, asimismo considerando la autonomía de elección de tiempo y lugar para atender sus responsabilidades de una forma mucho más eficiente y efectiva para el sistema. De ahí se desprende la revisión documental desarrollada y el planteamiento de una aproximación de solución, eventualmente viable.
Intervención del padre en las actividades de crianza del hijo o hija
Authors: Giler-Giler Rosa , Cevallos-Vera Katherine , Mendoza-Castro Andrea 
Published: February 2023

El presente artículo tiene por objeto el estudio de las funciones del padre en la crianza del niño o niña en el entorno familiar, por generaciones se han designado roles en la sociedad: a los hombres como el proveedor del hogar, a las mujeres como un ser reproductivo, quien lleva 9 meses en su vientre al infante y da lactancia materna, esta desigualdad en la distribución de las actividades domésticas y de cuidado es lo que motiva en este artículo a analizar la participación de los hombres en las actividades de crianza en el hogar, particularmente en el cuidado directo de hijos e hijas de 1 a 3 años. Se busca dar respuesta a preguntas como ¿participan los hombres padres en las actividades de crianza, con hijos e hijas de 1 a 3 años, en las actividades de cuidado directo?, ¿en qué actividades y cuánto tiempo le dedican a las mismas? ¿Cuál es la responsabilidad del padre en el hogar? Para el desarrollo de este trabajo se utilizó como técnica la encuesta dirigida a 36 familias del Centro de Desarrollo Infantil María de la Merced de la ciudadela Jaime Roldos, del cantón Junín, provincia de Manabí, logrando extraer las conclusiones de este trabajo investigativo.
A experiência dos familiares frente à participação em visitas virtuais aos pacientes internados na UTI-COVID durante a pandemia
Authors: Batista Juliana dos Santos , Bastos Mayara Yasmim Borges , Palma Thamires , Aceti Daniela 
Published: February 2023

Objetivo: Analisar a experiência dos familiares que realizaram visita virtual (VV) à pacientes internados na UTI COVID do Hospital Sírio Libanês, durante a pandemia. Método: Estudo transversal descritivo e exploratório, que utilizou entrevista semi-estruturada desenhada para tal finalidade. As questões de múltipla escolha foram analisadas através de estatísticas descritivas e a questão aberta através do método Discurso do Sujeito Coletivo (DSC), que trabalha a análise dos dados empíricos de natureza verbal para configurar um sujeito coletivo portador de discurso social. Resultados e discussão: População do estudo majoritariamente formada adultos jovens (89,47%) do sexo masculino (77,60%), com escolaridade superior (65,78%), conectados da cidade de São Paulo (63%), que nunca tinham participado de VV (93,42%). Consideraram o tempo de visita satisfatório (88,15%) e a realização extremamente importante (78,94%), sentindo-se melhor emocionalmente após a realização (92,1%). As temáticas identificadas no relato de experiência foram categorizadas como: alternativa diante a restrição de visitas, o medo de contaminação e a distância, recurso de enfrentamento emocional e de suporte ao luto, participação da família no cuidado e ajuda na recuperação do paciente, presença de ansiedade por quebra de expectativas sobre o funcionamento da visita, alternativa para aproximação com pacientes intubados, para despedida e condução por psicólogos proporcionando cuidado e acolhimento. Conclusão: A experiência com VV foi considerada exitosa, sendo recurso de aproximação para familia, podendo se estender para ocasiões além da pandemia. Sugere-se ampliar as discussões sobre melhores práticas em VV, incluindo aspectos relacionados à segurança e autonomia.
Pemberian Myofascial Release untuk Menurunkan Nyeri Myofascial Low Back Pain pada Karyawan Administrasi
Authors: Yani Fitri 
Published: February 2023

Nyeri Myofascial adalah masalah nyeri musculoskeletal yang umum, dengan nyeri myofascial punggung bagian bawah (myofascial low back pain) menjadi salah satu daerah yang paling sering terkena. Myofascial release merupakan intervensi yang banyak digunakan untuk mengurangi nyeri myofascial. Penelitian ini bertujuan membuktikan myofascial release dapat menurunkan nyeri myofascial punggung bagian bawah (myofascial low back pain). Penelitian menggunakan desain experimental dengan pre-test dan post test one grup yang berisikan 10 sampel dengan dosis intervensi diberikan selama 4 minggu dengan 3 kali dalam seminggu. Pengukuran nyeri menggunakan Visual analogue scale dan dengan cara mengukur nyeri sebelum dan sesudah intervensi. Sampel dengan kriteria inklusi positif nyeri myofascial low back pain dan kriteria eksklusi diantaranya subjek memiliki kelainan fraktur clavicula atau vertebra. Terjadi penurunan nyeri pada sampel yang berarti menunjukkan myofascial release dapat menurunkan nyeri secara bermakna.
4-Allyl-2-methoxyphenol modulates the expression of genes involved in efflux pump, biofilm formation and sterol biosynthesis in azole resistant Aspergillus fumigatus
Authors: Sen Pooja , Gupta Lovely , Vijay Mukund , Vermani Sarin Maansi , Shankar Jata , Hameed Saif , Vijayaraghavan Pooja 
Published: February 2023

IntroductionAntifungal therapy for aspergillosis is becoming problematic because of the toxicity of currently available drugs, biofilm formation on host surface, and increasing prevalence of azole resistance in Aspergillus fumigatus. Plants are rich source of bioactive molecules and antimicrobial activity of aromatic bioactive compounds draws attention because of its promising biological properties. The present study elucidated the antibiofilm activity of 4-allyl-2-methoxyphenol (eugenol) against azole-resistant environmental A. fumigatus isolates.MethodsSoil samples were collected from agricultural fields across India; azole-resistant A. fumigatus (ARAF) were isolated followed by their molecular identification. Antibiofilm activity of eugenol was calculated via tetrazolium based-MTT assay. The expression of the multidrug efflux pumps genes MDR1, MDR4, transporters of the MFS gene, erg11A gene encoding 14α demethylase, and transcription regulatory genes, MedA, SomA and SrbA, involved in biofilm formation of A. fumigatus were calculated by quantitative real time PCR.ResultsOut of 89 A. fumigatus isolates, 10 were identified as azole resistant. Eugenol exhibited antibiofilm activity against ARAF isolates, ranging from 312 to 500 µg/mL. Confocal laser scanning microscopy analysis revealed absence of extracellular matrix of ARAF biofilm after eugenol treatment. The gene expression indicated significantly low expression of efflux pumps genes MDR1, MDR4, erg11A and MedA in eugenol treated ARAF isolates when compared with untreated isolates.ConclusionsOur results demonstrate that eugenol effects the expression of efflux pump and biofilm associated genes as well as inhibits biofilm formation in azole resistant isolates of A. fumigatus.
In vitro digestion and human gut microbiota fermentation of Bletilla striata polysaccharides and oligosaccharides
Authors: Wang Qiqi , Chen Huimin , Yin Mingzhu , Cheng Xue , Xia Hui , Hu Haiming , Zheng Junping , Zhang Zhigang , Liu Hongtao 
Published: February 2023

BackgroundBletilla striata is one of the commonly used traditional Chinese medicine. B. striata polysaccharides (BP) and oligosaccharides (BO) are one of the main components of B. striata, which have been proved to have a variety of biological activities. However, the digestion and fermentation characteristics of BP and BO are still unclear.MethodsThe study evaluated different prebiotic effects of BP and BO by in vitro simulating digestion and gut microbiota fermentation.ResultsThe results show that the simulating saliva partly degraded BP, but had no effect on BO. The molecular weights of BP and BO remained basically unchanged in gastric and intestinal digestion. In addition, BP and BO could be rapidly degraded and utilized by gut microbiota. During in vitro fermentation, the growth rates of the BP and BO groups were higher than that of the Control group and the pH value and total carbohydrate content in BP group and BO group decreased significantly. Although the reducing sugar level in the BO group decreased rapidly, it remained at a low level in the BP group. Both BP and BO improved the composition and structure of gut microbiota, indicative of the upregulated abundances of Streptococcus and Veillonella, and the downregulated populations of Escherichia and Bacteroides. There were differences in the SCFA production by gut microbiota and antioxidant activities between the BP and BO groups. The fermentation broth of the BP group displayed a stronger suppression of O2-, but a higher scavenging effect on DPPH for the BO group.ConclusionsBP and BO displayed different digestion and fermentation characteristics in vitro due to their distinct polymerization degrees. The study point towards the potential of BP and BO as prebiotics in the application to human diseases by selectively regulating gut microbiota in the future.
Value of baseline characteristics in the risk prediction of atrial fibrillation
Authors: He Jiacheng , Liu Sen , Yang Cuiwei , Wei Yong 
Published: February 2023

IntroductionAtrial fibrillation (AF) is prone to heart failure and stroke. Early management can effectively reduce the stroke rate and mortality. Current clinical guidelines screen high-risk individuals based solely on age, while this study aims to explore the possibility of other AF risk predictors.MethodsA total of 18,738 elderly people (aged over 60 years old) in Chinese communities were enrolled in this study. The baseline characteristics were mainly based on the diagnosis results of electrocardiogram (ECG) machine during follow up, accompanied by some auxiliary physical examination basic data. After the analysis of both independent and combined baseline characteristics, AF risk predictors were obtained and prioritized according to the results. Independent characteristics were studied from three aspects: Chi-square test, Mann–Whitney U test and Cox univariate regression analysis. Combined characteristics were studied from two aspects: machine learning models and Cox multivariate regression analysis, and the former was combined with recursive feature elimination method and voting decision.ResultsThe resulted optimal combination of risk predictors included age, atrial premature beats, atrial flutter, left ventricular hypertrophy, hypertension and heart disease.ConclusionPatients diagnosed by short-time ECG machines with the occurrence of the above events had a higher probability of AF episodes, who are suggested to be included in the focus of long-term ECG monitoring or increased screening density. The incidence of risk predictors in different age ranges of AF patients suggests differences in age-specific patient management. This can help improve the detection rate of AF, standardize the management of patients, and slow down the progression of AF.
The use of modified TI-RADS using contrast-enhanced ultrasound features for classification purposes in the differential diagnosis of benign and malignant thyroid nodules: A prospective and multi-center study
Authors: Zhou Ping , Chen Feng , Zhou Peng , Xu Lifeng , Wang Lei , Wang Zhiyuan , Yu Yi , Liu Xueling , Wang Bin , Yan Wei , Zhou Heng , Tao Yichao , Liu Wengang 
Published: February 2023

ObjectivesTo evaluate the diagnostic efficacy of a modified thyroid imaging reporting and data system (TI-RADS) in combination with contrast-enhanced ultrasound (CEUS) for differentiating between benign and malignant thyroid nodules and to assess inter-observer concordance between different observers.MethodsThis study included 3353 patients who underwent thyroid ultrasound (US) and CEUS in ten multi-centers between September 2018 and March 2020. Based on a modified TI-RADS classification using the CEUS enhancement pattern of thyroid lesions, ten radiologists analyzed all US and CEUS examinations independently and assigned a TI-RADS category to each thyroid nodule. Pathology was the reference standard for determining the diagnostic performance (accuracy (ACC), sensitivity (SEN), specificity (SPN), positive predictive value (PPV), and negative predictive value (NPV)) of the modified TI-RADS for predicting malignant thyroid nodules. The risk of malignancy was stratified for each TI-RADS category-based on the total number of benign and malignant lesions in that category. ROC curve was used to determine the cut-off value and the area under the curve (AUC). Cohen’s Kappa statistic was applied to assess the inter-observer agreement of each sonological feature and TI-RADS category for thyroid nodules.ResultsThe calculated malignancy risk in the modified TI-RADS categories 5, 4b, 4a, 3 and 2 nodules was 95.4%, 86.0%, 12.0%, 4.1% and 0%, respectively. The malignancy risk for the five categories was in agreement with the suggested malignancy risk. The ROC curve showed that the AUC under the ROC curve was 0.936, and the cutoff value of the modified TI-RADS classification was &gt;TI-RADS 4a, whose SEN, ACC, PPV, NPV and SPN were 93.6%, 91.9%, 90.4%, 93.7% and 88.5% respectively. The Kappa value for taller than wide, microcalcification, marked hypoechoic, solid composition, irregular margins and enhancement pattern of CEUS was 0.94, 0.93, 0.75, 0.89, 0.86 and 0.81, respectively. There was also good agreement between the observers with regards to the modified TI-RADS classification, the Kappa value was 0.80.ConclusionsThe actual risk of malignancy according to the modified TI-RADS concurred with the suggested risk of malignancy. Inter-observer agreement for the modified TI-RADS category was good, thus suggesting that this classification was very suitable for clinical application.
For small (1-3cm) nonfunctional adrenal incidentaloma (NFAI), which option is more appropriate for conservative treatment or surgery?
Authors: Li Xuwen , Xiao Song , Zhan Xiangpeng , Yu Yue , Zhang Cheng , Xi Haibo , Wang Gongxian , Zhou Xiaochen 
Published: February 2023

ObjectiveTo compare the efficacy and safety between conservative treatment and surgery for the patients with small (1-3cm) nonfunctional adrenal incidentaloma (NFAI).MethodsThe patients with small (1-3cm) NFAI who received conservative treatment or surgery in our hospital from November 2018 to December 2019 were retrospectively collected. A total of 83 patients were included in this study. They were divided into two groups according to the treatment methods: the surgery group (n=51) and the conservative treatment group (n=32).Then patients’ demographics, tumor characteristics, functional indicators and complications were compared. Statistical analysis was performed using t-test for continuous variables and Pearson chi-square test or Fisher’s exact test for categorical variables.ResultsAt the time of diagnosis, after 3 months, after 6 months, after 12 months, and after 24 months, we found that there was no significant difference between the two groups in systolic blood pressure, diastolic blood pressure, serum potassium levels, and hormone levels. 51 patients chose to have surgery, of which 41 patients chose RLA and 10 patients chose RARLA. RARLA group patients had the highest total cost and conservative treatment group patients had the lowest cost, and the difference was significant (P &lt; 0.001). There was no significant difference in tumor size in the conservative treatment group between at the time of diagnosis and after 24 months (P = 0.305).ConclusionSurgical treatment is more effective for 1-3cm NFAI, but conservative treatment is safer and more economical. Follow-up after conservative or surgical treatment is necessary.