bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PROSES PENGAJUAN KREDIT USAHA RAKYAT (KUR) BANK NEGARA INDONESIA (PERSERO) TBK KCU SUNGAI PENUH TAHUN 2022
Authors: Hastin Mira 
Published: September 2023

Penelitian ini bertujuan untuk menganalisa prosedur pengajuan Kredit Usaha Rakyat pada Bank BNI Cabang Sungai Penuh, syarat pengajuan Kredit Usaha Rakyat pada Bank BNI Cabang Sungai Penuh, BNI menyikapi berkas permohonan nasabah yang lengkap tetapi belum dilakukan perjanjian kredit. Jenis penelitian yang digunakan adalah deskriptif kualitatif. Sumber data yang digunakan adalah sumber data primer yang bersumber dari observasi dan wawancara. Sedangkan data sekunder yaitu sumber data yang diperoleh dari dokumentasi dan studi pustaka. Pengumpulan data field research melalui observasi, wawancara dan dokumentasi. Hasil penelitian ini menunjukan bahwa PT Bank Negara Indonesia (persero), TBK KCU. Sungai Penuh sudah menjalani proses pengajuan kredit sesuai standar operasional prosedur dan telah terlaksana dengan efektif dan efisien. Syarat pengajuan kredit usaha rakyat adalah usaha layak untuk dibiayai yang dimulai dari pengisian formulir permohonan kredit, penyerahan berkas persyaratan, pemeriksaan berkas persyaratan, wawancara, pemeriksaan ke lapangan, keputusan kredit, perjanjian kredit dan pencairan kredit. Persyaratan KUR ditetapkan oleh Permenko dan BNI. Syaratnya berupa dokumen-dokumen diantaranya: usaha layak untuk dibiayai, Identitas diri beserta pasangan, memiliki legalitas usaha seperti SIUP dan NPWP jaminan yang diserahkan antara lain: SHM/SHGB+IMB. Persyaratan tambahan untuk nasabah yang melakukan top up adalah rekening koran pinjaman 6 bulan. Menyikapi berkas permohonan kredit nasabah yang lengkap akan tetapi belum dilakukan perjanjian kredit yaitu dengan mengkonsolidasi berkas-dikirim ke wilayah dan pusat. Dalam pemberian kredit, BNI cabang sungai penuh menggunakan prinsip 5 c yaitu character yaitu watak atau sifat, capacity yaitu kemampuan, capital yakni modal, condition of economy yaitu kondisi ekonomi atau faktor eksternal dan collateral yaitu jaminan.
Pandemi Covid-19 Mengungkapkan Peran Non-Manusia Dalam Tradisi Silaturahmi
Authors: Tihurua Ode Zulkarnain Sahji 
Published: September 2023

Pandemic covid-19 telah mengungkapkan pentingnya peran non-manusia dalam kehidupan kita (baca: manusia), termasuk dalam menciptakan atau merubah tradisi yang kita pegang sejak lama. Artikel ini mengkaji tradisi “Jalan Awat” yang dilakukan masyarakat Geser pada tanggal 2 dan tanggal 3 setiap bulan Syawal (hari kedua dan ketiga hari raya Idul Fitri) di Era Pandemi Covid-19. Tradisi jalan awat merupakan tradisi silaturahmi yang banyak dipraktekan oleh berbagai kebudayaan di Indonesia. Temuan penelitian ini mengungkapkan bagaimana satu entitas non-manusia (baca: covid-19) yang ukurannya sangat mikro mampu merubah tradisi silaturahmi suatu masyarakat yang sudah dilaksanakan secara turun-temurun. Tulisan ini menggunakan konsep “entanglements” dari Anna L. Tsing dan konsep “konstruksi budaya lingkungan” dari Roy Ellen untuk menjelaskan bagaimana keterlibatan non-manusia dalam kehidupan bersama dengan manusia dalam pembentukan dan perubahan tradisi silaturahmi. Artikel ini juga menemukan model silaturahmi yang khas pada tradisi jalan awat yang disebut sebagai “silaturahmi kolektif”. Artikel ini merupakan hasil penelitian lapangan yang dilakukan oleh penulis di desa Geser pada idul fitri tahun 2020 dan tahun 2021.
Investigaciones sobre la poesía del siglo de Oro (2017-2020)
Authors: Rodríguez Mansilla Fernando 
Published: September 2023

Este artículo recoge las principales tendencias críticas de la investigación dedicada a la poesía del Siglo de Oro en el periodo 2017-2020. Mediante la recopilación de ediciones, monografías, volúmenes monográ/cos en revistas y libros, así como artículos, se identi/can los principales temas y perspectivas que se han generado en estos últimos años. Se comentan, igualmente, las líneas de investigación de los grupos más activos dedicados a la poesía aurisecular. Se veri/ca que esta área de estudio se encuentra en buen estado de salud, dado el volumen de producción, la innovación en los enfoques y la vitalidad de los grupos.
La escritura del remedio en el "Guzmán de Alfarache" de Mateo Alemán y en el Apócrifo de Mateo Luján de Saavedra
Authors: Le Gal-Grasset Gaëlle 
Published: September 2023

Abundan en el Guzmán de Alfarache las referencias a la materia médica y, más particularmente, a los remedios. Tanto la cantidad como la especi+cidad de los empleos literales y metafóricos recalcan el profundo arraigamiento de la escritura del remedio en la autobiografía +cticia de Mateo Alemán. No obstante, y a pesar de las líneas de continuidad que existen entre la primera parte de 1599 y la segunda de 1604, cabe preguntarse qué papel desempeñó la secuela apócrifa de 1602 en la reescritura de la segunda parte auténtica alemaniana. Este artículo pretende mostrar cómo, al imitar la escritura del remedio de Mateo Alemán, Mateo Luján de Sayavedra obligó a su ilustre predecesor a rea+rmar su poética propia, diferenciándose del copiador.
El vino como remedio y la "Vinosa enfermedad". Juan de la Cueva frente a la tradición del Elogio paradójico
Authors: Molinaro Antonietta 
Published: September 2023

El trabajo se propone analizar un elogio paradójico sobre el vino y su palinodia por Juan de la Cueva. Tras destacar las peculiaridades temáticas y formales del vino como objeto de alabanza, entre burla y erudición, la atención se centra en el marcado componente polémico de las dos composiciones. La resemantización por parte de Cueva del reconocido tópico burlesco de la oposición entre Baco y Febo se interpreta a la luz de la actitud con,ictiva del autor hacia los entornos académicos sevillanos y de su frustrada aspiración de reconocimiento poético en el parnaso hispalense.
A case report on digital preoperative design, clinical application and finite element analysis for a patient with ankylosing spondylitis kyphosis
Authors: Zhu Lei , Zhang Chi , Peng Li , Cheng Zifei , Liang Xiuwen 
Published: September 2023

Objective: By assessing a case of ankylosing spondylitis (AS) after thoracic lumbar protrusion deformity in a digital model and verifying its effectiveness after surgery for orthopaedic surgery process simulation, a finite element model was established for biomechanical experiments.Method: A 56-year-old patient with AS underwent preoperative thoracic lumbar spine computed tomography. The data were reconstructed using MIMICS16.0 software and modelled to design and measure the nailing parameters. A three-dimensional model was established using ANSYS14.0 software, and the actual surgical procedure was simulated using biomechanical experiments. The model was verified by comparing the X-ray films obtained from patients during preoperative forward bending, stretching and lateral flexion, with the model further tested using the Hueter-Volkmann principle.Result: On comparing the measurements across three different load cases (forward bending, after stretching and lateral flexion) in patients with AS after thoracic lumbar protrusion deformity and the original X-ray images, no difference was found between the model of deformation and real patient movement displacement across the vertebral body. On simulating the stress distribution, the measured T10-L4 vertebral body stress values at every point in the injured vertebrae were, on the whole, directed at both the upper and lower ends and exhibited a decreasing trend, and the stress distribution gradually decreased from the injured vertebrae (T12 and L1) to the upper and lower ends.Conclusion: The accuracy of the research model is high, the geometric similarity is good and relevant applied anatomy can be undertaken using the model parameter measurement. This study provides a successful example of the application of digital technology in the field of spinal deformity and a novel idea for the treatment of AS-related kyphosis.
Advances of nanotechnology for intracerebral hemorrhage therapy
Authors: Wang Jiayan , Wang Tianyou , Fang Mei , Wang Zexu , Xu Wei , Teng Bang , Yuan Qijuan , Hu Xin 
Published: September 2023

Intracerebral hemorrhage (ICH), the most devastating subtype of stoke, is of high mortality at 5 years and even those survivors usually would suffer permanent disabilities. Fortunately, various preclinical active drugs have been approached in ICH, meanwhile, the therapeutic effects of these pharmaceutical ingredients could be fully boosted with the assistance of nanotechnology. In this review, besides the pathology of ICH, some ICH therapeutically available active drugs and their employed nanotechnologies, material functions, and therapeutic principles were comprehensively discussed hoping to provide novel and efficient strategies for ICH therapy in the future.
A graph-based explanatory model for room-based energy efficiency analysis based on BIM data
Authors: Kiavarz Hamid , Jadidi Mojgan , Esmaili Payam 
Published: September 2023

Introduction: In recent years, the growing interest in building energy consumption and estimation has led to a wealth of energy data and Building Information Modelling (BIM), providing ample opportunities for data-driven algorithms to be widely applied in the building industry. However, despite promising accuracy in data-driven models for building energy estimation, they only consider building elements and their attributes independently and neglect the interconnected relationship of building elements. Also, Current data-driven models lack interpretability and are often treated as black boxes. As a result, the models cannot be fully trusted for engineering without reasoning the underlying mechanisms behind the estimation.Method: This paper emphasizes the potential of graph-based learning algorithms, specifically GraphSAGE, in utilizing the enriched semantic, geometry, and room topology information derived from BIM data. The aim is to identify critical zones within the building based on their energy consumption characteristics. Besides that, the paper proposed a GraphSAGE explainable model by adopting the SHAP with the proposed NE-GraphSAGE prediction model to make more transparency behind the data-driven models.Results and Discussion: Preliminary results demonstrate the potential to improve pre-construction and post-construction steps by identifying critical zones in buildings and identifying the parameters which affected the efficiency of the zones with low energy consumption.
Identification and validation of a small molecule targeting ROR1 for the treatment of triple negative breast cancer
Authors: Gupta Shradheya R. R. , Ta Tram M. , Khan Maryam , Singh Archana , Singh Indrakant K. , Peethambaran Bela 
Published: September 2023

Introduction: Breast cancer is the most common cancer in women, with roughly 10–15% of new cases classified as triple-negative breast cancer (TNBC). Traditional chemotherapies are often toxic to normal cells. Therefore, it is important to discover new anticancer compounds that target TNBC while causing minimal damage to normal cells. Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1) is an oncofetal protein overexpressed in numerous human malignancies, including TNBC. This study investigated potential small molecules targeting ROR1.Methodology: Using AutoDock Vina and Glide, we screened 70,000 chemicals for our investigation. We obtained 10 representative compounds via consensus voting, deleting structural alerts, and clustering. After manual assessment, compounds 2 and 4 were chosen for MD simulation and cell viability experiment. Compound 4 showed promising results in the viability assay, which led us to move further with the apoptosis assay and immunoblotting.Results: Compound 4 (CID1261330) had docking scores of −6.635 and −10.8. It fits into the pocket and shows interactions with GLU64, ASP174, and PHE93. Its RMSD fluctuates around 0.20 nm and forms two stable H-bonds indicating compound 4 stability. It inhibits cell proliferation in MDA-MB-231, HCC1937, and HCC1395 cell lines, with IC50 values of approximately 2 μM to 10 μM, respectively. Compound 4 did not kill non-malignant epithelial breast cells MCF-10A (IC50 &gt; 27 μM). These results were confirmed by the significant number of apoptotic cells in MDA-MB-231 cells (47.6%) but not in MCF-10A cells (7.3%). Immunoblot analysis provided additional support in the same direction.Discussion: These findings collectively suggest that compound 4 has the potential to effectively eliminate TNBC cells while causing minimal harm to normal breast cells. The promising outcomes of this study lay the groundwork for further testing of compound 4 in other malignancies characterized by ROR1 upregulation, serving as a proof-of-concept for its broader applicability.
Safety and efficacy of His-Purkinje system pacing in the treatment of patients with atrial fibrillation and heart failure: a systematic review and meta-analysis
Authors: Guan Lin , Wang Chuanhe , Guan Xueqing , Cheng Gong , Sun Zhijun 
Published: September 2023

AimTo evaluate the safety and efficacy of the His-Purkinje system pacing (HPCSP) in the treatment of individuals with atrial fibrillation (AF) complicated by heart failure (HF).MethodsThe PubMed, Cochrane Library, Web of Science, and Embase databases were searched through September 1, 2022. The literature was initially screened based on the inclusion and exclusion criteria. The baseline characteristics of the subjects, implantation success rate, New York Heart Association (NYHA) classification, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd), QRS duration, pacing threshold, and impedance were extracted and summarized; statistical analysis was performed using RevMan 5.3 software.ResultsIn all, 22 articles were included, involving 1,445 patients. Compared to biventricular pacing (BiVP), HPCSP resulted in improved cardiac function, including increased ejection fraction (MD = 5.69, 95% CI: 0.78–10.60, P = 0.02) and decreased LVEDd (MD = −3.50, 95% CI: −7.05–0.05, P = 0.05). It was also correlated with shorter QRS duration (MD = −38.30, 95% CI: −60.71–−15.88, P &lt; 0.01) and reduced all-cause mortality and rehospitalization events (RR = 0.72, 95% CI: 0.57–0.91, P &lt; 0.01) in patients. Left bundle branch pacing (LBBP) lowered the pacing threshold (MD = 0.47; 95% CI: 0.25–0.69; P &lt; 0.01), and there was no statistical difference in the rate of endpoint events when comparing these two physiologic pacing modalities (RR = 1.56, 95% CI: 0.87–2.80, P = 0.14).ConclusionThe safety and efficacy of HPCSP in patients with AF and HF were verified in this meta-analysis. HPCSP can reverse cardiac remodeling and has great clinical application value. Relatively speaking, His-bundle pacing (HBP) can maintain better ventricular electro-mechanical synchronization, and the pacing parameters of LBBP are more stable.Systematic Review RegistrationPROSPERO (CRD42022336109)
The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study
Authors: Salmanipour Alireza , Ghaffari Jolfayi Amir , Sabet Khadem Nazanin , Rezaeian Nahid , Chalian Hamid , Mazloomzadeh Saeideh , Adimi Sara , Asadian Sanaz 
Published: September 2023

BackgroundPrompt interventions prevent adverse events (AE) in hypertrophic cardiomyopathy (HCM). We evaluated the pattern and the predictive role of feature tracking (FT)-cardiac magnetic resonance (CMR) imaging parameters in an HCM population with a normal left ventricular ejection fraction (LVEF) and a low fibrosis burden.MethodsThe CMR and clinical data of 170 patients, consisting of 142 HCM (45 ± 15.7 years, 62.7% male) and 28 healthy (42.2 ± 11.26 years, 50% male) subjects, who were enrolled from 2015 to 2020, were evaluated. HCM patients had a normal LVEF with a late gadolinium enhancement (LGE) percentage below 15%. Between-group differences were described, and the potent predictors of AE were determined. A P-value below 0.05 was considered significant.ResultsLV global longitudinal, circumferential, and radial strains (GLS, GCS, and GRS, respectively) and the LV myocardial mass index (MMI) were different between the healthy and HCM cases (all Ps &lt; 0.05). Strains were significantly impaired in the HCM patients with a normal MMI. A progressive decrease in LVGLS and a distinct fall in LVGCS were noted with a rise in MMI. AE were predicted by LVGLS, LVGCS, and the LGE percentage, and LVGCS was the single robust predictor (HR, 1.144; 95% CI, 1.080–1.212; P = 0.001). An LVGCS below 16.2% predicted AE with 77% specificity and 58% sensitivity.ConclusionsLV strains were impaired in HCM patients with a normal EF and a low fibrosis burden, even in the presence of a normal MMI. CMR parameters, especially FT-CMR values, predicted AE in our HCM patients.
Opportunities for digital health technology: identifying unmet needs for bipolar misdiagnosis and depression care management
Authors: Kark Sarah M. , Worthington Michelle A. , Christie Richard H. , Masino Aaron J. 
Published: September 2023

IntroductionDigital health technologies (DHTs) driven by artificial intelligence applications, particularly those including predictive models derived with machine learning methods, have garnered substantial attention and financial investment in recent years. Yet, there is little evidence of widespread adoption and scant proof of gains in patient health outcomes. One factor of this paradox is the disconnect between DHT developers and digital health ecosystem stakeholders, which can result in developing technologies that are highly sophisticated but clinically irrelevant. Here, we aimed to uncover challenges faced by psychiatrists treating patients with major depressive disorder (MDD). Specifically, we focused on challenges psychiatrists raised about bipolar disorder (BD) misdiagnosis.MethodsWe conducted semi-structured interviews with 10 United States–based psychiatrists. We applied text and thematic analysis to the resulting interview transcripts.ResultsThree main themes emerged: (1) BD is often misdiagnosed, (2) information crucial to evaluating BD is often occluded from clinical observation, and (3) BD misdiagnosis has important treatment implications.DiscussionUsing upstream stakeholder engagement methods, we were able to identify a narrow, unforeseen, and clinically relevant problem. We propose an organizing framework for development of digital tools based upon clinician-identified unmet need.
Testosterone deficiency impairs cardiac interfibrillar mitochondrial function and myocardial contractility while inducing oxidative stress
Authors: do Val Lima Patrícia Ribeiro , Ronconi Karoline Sousa , Morra Elis Aguiar , Rodrigues Paula Lopes , Ávila Renata Andrade , Merlo Eduardo , Graceli Jones B. , Simões Maylla Ronacher , Stefanon Ivanita , Ribeiro Júnior Rogério Faustino 
Published: September 2023

IntroductionClinical studies have shown that low levels of endogenous testosterone are associated with cardiovascular diseases. Considering the intimate connection between oxidative metabolism and myocardial contractility, we determined the effects of testosterone deficiency on the two spatially distinct subpopulations of cardiac mitochondria, subsarcolemmal (SSM) and interfibrillar (IFM).MethodsWe assessed cardiac function and cardiac mitochondria structure of SSM and IFM after 12 weeks of testosterone deficiency in male Wistar rats. Results and DiscussionResults show that low testosterone reduced myocardial contractility. Orchidectomy increased total left ventricular mitochondrial protein in the SSM, but not in IFM. The membrane potential, size and internal complexity in the IFM after orchidectomy were higher compared to the SHAM group. However, the rate of oxidative phosphorylation with all substrates in the IFM after orchidectomy was lower compared to the SHAM group. Testosterone replacement restored these changes. In the testosterone-deficient SSM group, oxidative phosphorylation was decreased with palmitoyl-L-carnitine as substrate; however, the mitochondrial calcium retention capacity in IFM was increased. There was no difference in swelling of the mitochondria in either group. These changes in IFM were followed by a reduction in phosphorylated form of AMP-activated protein kinase (p‐AMPK‐α), peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PGC‐1α) translocation to mitochondria and decreased mitochondrial transcription factor A (TFAM). Testosterone deficiency increased NADPH oxidase (NOX), angiotensin converting enzyme (ACE) protein expression and reduced mitochondrial antioxidant proteins such as manganese superoxide dismutase (Mn-SOD) and catalase in the IFM. Treatment with apocynin (1.5 mM in drinking water) normalized myocardial contractility and interfibrillar mitochondrial function in the testosterone depleted animals. In conclusion, our findings demonstrate that testosterone deficiency leads to reduced myocardial contractility and impaired cardiac interfibrillar mitochondrial function. Our data suggest the involvement of reactive oxygen species, with a possibility of NOX as an enzymatic source.
Effects of concurrent aerobic and resistance training on vascular health in type 2 diabetes: a systematic review and meta-analysis
Authors: Chen Shengju , Zhou Kaixiang , Shang Huayu , Du Mingyang , Wu Linfeng , Chen Yu 
Published: September 2023

ObjectiveTo determine the impacts of concurrent aerobic and resistance training on vascular structure (IMT) and function (PWV, FMD, NMD) in type 2 diabetes (T2D).MethodsThe electronic databases PubMed, Web of Science Core Collection, Cochrane Library, Embase, Scopus, CINAHL, and SPORTDiscus were systematically searched for articles on “type 2 diabetes” and “concurrent training” published from inception to August 2, 2022. We included randomized controlled trials that examined the effects of concurrent training versus passive controls on IMT, PWV, FMD and NMD in T2D.ResultsTen studies were eligible, including a total of 361 participants. For IMT, concurrent training showed a slight decrease by 0.05 mm (95% CI −0.11 to 0.01, p &gt; 0.05). concurrent training induced an overall significant improvement in FMD by 1.47% (95% CI 0.15 to 2.79, p &lt; 0.05) and PWV by 0.66 m/s (95% CI −0.89 to −0.43, p &lt; 0.01) in type 2 diabetics. However, concurrent training seemed to exaggerate the impaired NMD (WMD = −2.30%, 95% CI −4.02 to −0.58, p &lt; 0.05).ConclusionsConcurrent training is an effective method to improve endothelial function and artery stiffness in T2D. However, within 24 weeks concurrent training exacerbates vascular smooth muscle dysfunction. More research is needed to explore whether longer and/or higher-intensity concurrent training interventions could enhance the vascular structure and smooth muscle function in this population.Systematic review registrationwww.crd.york.ac.uk/PROSPERO/, identifier CRD42022350604.