bluuebunny/crossref_metadata_2025_split huggingface dataset:
O uso de inibidores da SGLT2 e o seu impacto na doença arterial coronariana: Uma revisão de literatura
Authors: Batista Paulo Eduardo Mallmann , Monges Adriana Ester Arzamendia , Baldissera Pâmela Mantovani 
Published: September 2023

Introdução: A Síndrome Coronariana Aguda é responsável por mais de um milhão das internações hospitalares por ano. Pessoas com Diabetes Mellitus tipo 2 possuem um fator de risco aumentado para desenvolver tal síndrome. Os inibidores do co-transportador sódio glicose tipo 2 (SGLT2), medicação inicialmente desenvolvida como hipoglicemiante, vêm apresentando respostas favoráveis à proteção de eventos cardiovasculares nesta população. Objetivo: Esta revisão busca avaliar o benefício do uso de inibidores da SGLT2 em pacientes com doença arterial coronariana e sua relação com os desfechos clínicos (mortalidade e tempo de internação). Método: Trata-se de uma revisão narrativa da literatura, com levantamento de dados nas bases: Scielo, e MEDLINE. Incluíram-se artigos completos, nas linguagens inglês, português e espanhol, publicados a partir de 2005. Foram excluídos trabalhos duplicados, com fuga do objetivo, incompletos e em outros idiomas. Um total de 51 estudos compuseram esta revisão. Resultados e Discussão: Os inibidores SGLT2 são uma classe de agentes hipoglicemiantes que reduzem a reabsorção de glicose nos tubos renais proximais, aumentando a excreção urinária de glicose por meio de um mecanismo independente de insulina. Essas drogas são conhecidas por aliviar o estresse oxidativo e a disfunção endotelial, regular negativamente a inflamação sistêmica e a atividade simpática, estimular a produção de eritropoetina, melhorar a energia do coração e reduzir a pré-carga, a pós-carga e a massa ventricular. Embora seu impacto nos resultados ateroscleróticos em grandes estudos de resultados cardiovasculares tenha sido mínimo, essas propriedades deveriam, em teoria, ser benéficas para pacientes com síndrome coronariana aguda. Conclusão: inibidores da SGLT2 parecem promissores no tratamento de síndrome coronariana aguda, podendo ser capaz de melhorar a sobrevida e os desfechos nesta população.
A sífilis em Pernambuco: uma análise epidemiológica dos últimos cinco anos
Authors: Gomes Thamara Ferreira , Cunha Maximiliano Heleno Alexandre , Silva Monique Evelyn Alves da , Silva Natacha Ingrid Almeida da , Cavalcanti Luma Agra , Lima Amanda Vitória Costa , Marques Maria Fernanda Silva 
Published: September 2023

Objetivo: analisar o histórico epidemiológico de sífilis adquirida nos últimos cinco anos em Pernambuco. Metodologia: estudo epidemiológico ecológico, retrospectivo, descritivo com abordagem quantitativa, listando os números pertinentes necessários para a investigação do comportamento da sífilis adquirida no estado de Pernambuco. Resultados: no período de 2017 a 2021 foram notificados 30.594, deste total, os indivíduos de 20 a 29 anos responsáveis por 35,2% dos casos, o sexo masculino ultrapassa o número de casos de sífilis adquirida em todos os anos, exceto, em 2017. A doença está distribuída principalmente em pessoas de 20 a 29 anos, de raça/cor parda e branca, do sexo masculino e também no grupo daqueles que concluíram o ensino médio. Conclusão: a série temporal mostrou que houve aumento dos casos ao longo dos anos, bem como tendência de aumento da sífilis adquirida todavia a COVID-19 impactou nos dados de 2020. As ações de saúde devem continuar para melhorar o acesso ao diagnóstico e à notificação, com foco no tratamento, cura e ações de educação em saúde, para controlar e prevenir novos casos mesmo em municípios com alto índice de desenvolvimento humano.
Cirurgia videolaparoscópica na população pediátrica e suas aplicações
Authors: Teixeira Janayna Fraga 
Published: September 2023

Introdução: a cirurgia laparoscópica é um dos cinco principais campos de progresso na cirurgia pediátrica na última década do século XX e tem sido um avanço progressivo o que permitiu o desenvolvimento de um grande número de procedimentos cirúrgicos por técnica minimamente invasiva. No entanto, cabe analisar de forma especial como essa técnica se desenvolve em pacientes pediátricos, visto que, há complicações e aplicações para esse grupo da população, que necessita de avaliações criteriosas quando se realiza procedimentos. Objetivo: analisar relatos de caso, artigos e estudos que mostrem quais são as vantagens e as desvantagens da realização da cirurgia videolaparoscopia em pacientes pediátricos Metodologia: Trata-se de uma revisão sistemática de literatura com estudos publicados nas seguintes bases de dados: National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Biblioteca Virtual em Saúde (BVS) e EBSCO Information Services. Foram analisadas fontes relevantes inerentes ao tema, utilizando como um dos principais critérios a escolha de artigos atuais, originais e internacionais. Após leitura criteriosa das publicações, 4 artigos não foram utilizados devido aos critérios de exclusão. Assim, totalizaram-se 12 artigos científicos para a revisão. Resultados: A apendicite aguda demonstrou ser o maior exemplo de condição cirúrgica em que o cirurgião pediátrico pode realizar a videolaparoscopia e oferecer uma melhor evolução ao paciente em relação à técnica convencional. No entanto, notou-se que quanto menor a idade, maiores os riscos de prejuízos e não recomendação desse procedimento, especialmente em recém-nascidos. Conclusão: Em crianças, a videolaparoscopia é indicada com segurança para apendicectomia, retirada da vesícula, correção de fluxo gastroesofágico, testículo intra-abdominal (quando o testículo não desceu para a bolsa escrotal), cisto no ovário e alguns tipos de biópsias.
Neuropsychological and Clinical Correlations of Optical Coherence Tomography Findings in Patients with Schizophrenia
Authors: SAKALLI KANİ Ayşe , ŞAHİN ÇAM Cansun , BİBEROĞLU ÇELİK Esra , DURAL Uzay , DURAN DÖNMEZ Melike , AKKAYA TURHAN Semra , TOKER Ebru , YILDIZ Mesut 
Published: September 2023

Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters.
Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters.
Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior ( ρ – .422, p
Efficacy and mechanism of Baicao Fuyanqing suppository on mixed vaginitis based on 16S rRNA and metabolomics
Authors: Wang Qi , Wang Pengjiao , Yuan Minyan , Zhang Min , Zhang Shuo , Sun Xiaodong , Shang Leyuan , Liu Yujie , Zhao Yanni , Jiang Nan , Gao Xiuli 
Published: September 2023

BackgroundMixed vaginitis is the infection of the vagina by at least two different pathogens at the same time, both of which contribute to an abnormal vaginal environment leading to signs and symptoms. Baicao Fuyanqing suppository (BCFYQ) is a Miao ethnomedicine, used to treat various vaginitis. The aim of this study was to investigate the efficacy and possible mechanism of BCFYQ in the treatment of mixed vaginitis based on 16S rRNA high-throughput sequencing and metabonomics.MethodsEscherichia coli and Candida albicans were used to establish mixed vaginitis model in SD rats. Three groups of low, medium and high doses (0.18/0.36/0.64 g.kg-1) were established, and administered vaginally once a day for 6 consecutive days. After the last administration, vaginal pH and IL-1β, IL-2, IL-13 and IgA levels were measured, and the vaginal tissue was examined pathologically. In addition, the vaginal flora was characterised by 16S rRNA, and endogenous metabolites in the vaginal tissue were detected by UHPLC-Q-Exactive MS.ResultsCompared with the model group, BCFYQ can reduce the vaginal pH of rats, make it close to the normal group and improve the damaged vaginal epithelial tissue. The results of ELISA showed that BCFYQ decreased the levels of IL-1 β and IL-2 and increased the levels of IL-13 and IgA (P&lt;0.05). In addition, BCFYQ may increase the abundance of vaginal flora, especially Lactobacillus. The differential metabolite enrichment pathway suggests that the therapeutic mechanism of BCFYQ is mainly related to lipid metabolism and amino acid metabolism.ConclusionOur research shows that BCFYQ has a good therapeutic effect on mixed vaginitis. It repairs the damaged vaginal mucosa by regulating the vaginal flora and lipid metabolism disorders to improve the local immune function of the vagina and inhibit the growth and reproduction of pathogens.
Case report: A rare case of left ventricular noncompaction in two Chinese siblings with becker muscular dystrophy caused by deletion of exons 10 to 12 in the DMD gene
Authors: Li Jingdong , Zhu Wanyue , Su Guanhua , Zhu Feng , Shuai Xinxin , Meng Yidi , Zhang Jiaming , Chen Hao 
Published: September 2023

BackgroundBecker muscular dystrophy (BMD) is an inherited X-linked recessive condition resulting from mutations of the DMD gene encoding dystrophin. Left ventricular noncompaction (LVNC) is a rare cardiomyopathy morphologically characterized by abnormal myocardial trabeculae and deep recesses in the left ventricle. LVNC in BMD patients has only rarely been reported.Case reportIn the present study, we identified a deletion mutation in exons 10 to 12 (EX10_12 del) of the DMD gene (reference sequence NM_004006.2) in two Chinese siblings with BMD and LVNC by high throughput targeted next-generation sequencing (NGS) and quantitative polymerase chain reaction (qPCR). The proband was a 22-year-old man admitted with dyspnea, abdominal distention, and polyserositis. It is noteworthy that both the proband and his younger brother manifested progressive muscular atrophy and creatine kinase (CK) elevation. Light and electron microscopy examination of muscle biopsies showed the typical features of dystrophinopathies. Cardiac magnetic resonance imaging and echocardiography demonstrated that both brothers had an enlarged left ventricle, LVNC, and reduced left ventricular ejection fraction. Finally, the proband underwent heart transplantation at age 26 with an event-free follow-up over 4 years post-transplantation.ConclusionThis case further enriches our knowledge of the symptoms, genotype, cardiac performance, management, and prognosis of BMD patients complicated by LVNC. It is recommended that early comprehensive cardiac evaluation should be considered for patients with BMD to exclude LVNC, as this may have a significant impact on their prognosis.
Clinical characteristics and risk factors of in-hospital mortality among patients undergoing percutaneous pericardiocentesis
Authors: Wybraniec Maciej T. , Kampka Zofia , Drabczyk Mateusz , Zielonka Marek , Urbaniec Przemysław , Wypych Grzegorz , Cichoń Małgorzata , Szatan Tomasz , Jastrzębski Paweł , Mizia-Stec Katarzyna 
Published: September 2023

BackgroundPercutaneous pericardiocentesis represents a salvage procedure in case of cardiac tamponade and diagnostic procedure in chronic pericardial effusion of unknown source. The study aimed to analyze the clinical characteristics of patients subject to pericardiocentesis and the predictors of in-hospital mortality.MethodsThe study represents a registry that covered consecutive patients undergoing percutaneous pericardiocentesis from 2011 to 2022 in high-volume tertiary reference center. Electronic health records were queried to obtain demographic and clinical variables. The primary endpoint was in-hospital mortality, while secondary endpoint was the need for recurrent pericardiocentesis.ResultsOut of 132 456 patients hospitalized in the prespecified period, 247 patients were subject to percutaneous pericardiocentesis (53.9% women; median age of 66 years) who underwent 273 procedures. In-hospital death was reported in 14 patients (5.67%), while recurrent pericardiocentesis in 24 patients (9.72%). Iatrogenic cause was the most common etiology (42.5%), followed by neoplastic disease (23.1%) and idiopathic effusion (14.57%). In logistic regression analysis in-hospital mortality was associated with myocardial infarction (MI)-related etiology (p = 0.001) and recurrent/persistent cardiogenic shock (p = 0.001).ConclusionsIatrogenic etiology and neoplastic disease seem to be the most common indications for pericardiocentesis, while in-hospital mortality was particularly high in patients with spontaneous tamponade in the course of MI.
Investigation on the coordinated operation control technology of distributed new energy grid connection using artificial intelligence algorithms
Authors: Lu Yonglin , Sun Jinyong , Hu Jinying , Chen Rui , Liao Yifa , Shang Jingrui 
Published: September 2023

New energy power generation has strong randomness and volatility. Especially in the case of a high proportion of NE (network security) power generation, its sudden random power generation in a short period of time will seriously affect the stable operation of the power grid. Therefore, this paper proposes BP neural network algorithm to study the distributed NE grid-connected cooperative operation control technology. First of all, this paper studies the artificial intelligence algorithm in detail and applies it to the coordinated operation control of distributed NE grid-connected; then, based on the status quo of renewable energy PG (power generation), this paper establishes a suitable wind speed time series model, and thus proposes an optimization model based on a rolling scheduling optimization algorithm. The experimental results show that the average running time of the rolling scheduling optimization algorithm is maintained at about 0.2 s, which can effectively realize online operation. In addition, through rolling adjustment, the error between the total output curve of the unit and the actual total output curve of the unit can be significantly reduced. The research shows that the rolling scheduling optimization algorithm has a good optimization effect, can promote the coordinated development of wind farms and power systems, and increase the capacity of power systems.
A nomogram based on collagen signature for predicting the immunoscore in colorectal cancer
Authors: Jiang Wei , Yu Xian , Dong Xiaoyu , Long Chenyan , Chen Dexin , Cheng Jiaxin , Yan Botao , Xu Shuoyu , Lin Zexi , Chen Gang , Zhuo Shuangmu , Yan Jun 
Published: September 2023

ObjectivesThe Immunoscore can categorize patients into high- and low-risk groups for prognostication in colorectal cancer (CRC). Collagen plays an important role in immunomodulatory functions in the tumor microenvironment (TME). However, the correlation between collagen and the Immunoscore in the TME is unclear. This study aimed to construct a collagen signature to illuminate the relationship between collagen structure and Immunoscore.MethodsA total of 327 consecutive patients with stage I-III stage CRC were included in a training cohort. The fully quantitative collagen features were extracted at the tumor center and invasive margin of the specimens using multiphoton imaging. LASSO regression was applied to construct the collagen signature. The association of the collagen signature with Immunoscore was assessed. A collagen nomogram was developed by incorporating the collagen signature and clinicopathological predictors after multivariable logistic regression. The performance of the collagen nomogram was evaluated via calibration, discrimination, and clinical usefulness and then tested in an independent validation cohort. The prognostic values of the collagen nomogram were assessed using Cox regression and the Kaplan−Meier method.ResultsThe collagen signature was constructed based on 16 collagen features, which included 6 collagen features from the tumor center and 10 collagen features from the invasive margin. Patients with a high collagen signature were more likely to show a low Immunoscore (Lo IS) in both cohorts (P&lt;0.001). A collagen nomogram integrating the collagen signature and clinicopathological predictors was developed. The collagen nomogram yielded satisfactory discrimination and calibration, with an AUC of 0.925 (95% CI: 0.895-0.956) in the training cohort and 0.911 (95% CI: 0.872-0.949) in the validation cohort. Decision curve analysis confirmed that the collagen nomogram was clinically useful. Furthermore, the collagen nomogram-predicted subgroup was significantly associated with prognosis. Moreover, patients with a low-probability Lo IS, rather than a high-probability Lo IS, could benefit from chemotherapy in high-risk stage II and stage III CRC patients.ConclusionsThe collagen signature is significantly associated with the Immunoscore in the TME, and the collagen nomogram has the potential to individualize the prediction of the Immunoscore and identify CRC patients who could benefit from adjuvant chemotherapy.
Prediction of lactate concentrations after cardiac surgery using machine learning and deep learning approaches
Authors: Kobayashi Yuta , Peng Yu-Chung , Yu Evan , Bush Brian , Jung Youn-Hoa , Murphy Zachary , Goeddel Lee , Whitman Glenn , Venkataraman Archana , Brown Charles H. 
Published: September 2023

BackgroundAlthough conventional prediction models for surgical patients often ignore intraoperative time-series data, deep learning approaches are well-suited to incorporate time-varying and non-linear data with complex interactions. Blood lactate concentration is one important clinical marker that can reflect the adequacy of systemic perfusion during cardiac surgery. During cardiac surgery and cardiopulmonary bypass, minute-level data is available on key parameters that affect perfusion. The goal of this study was to use machine learning and deep learning approaches to predict maximum blood lactate concentrations after cardiac surgery. We hypothesized that models using minute-level intraoperative data as inputs would have the best predictive performance.MethodsAdults who underwent cardiac surgery with cardiopulmonary bypass were eligible. The primary outcome was maximum lactate concentration within 24 h postoperatively. We considered three classes of predictive models, using the performance metric of mean absolute error across testing folds: (1) static models using baseline preoperative variables, (2) augmentation of the static models with intraoperative statistics, and (3) a dynamic approach that integrates preoperative variables with intraoperative time series data.Results2,187 patients were included. For three models that only used baseline characteristics (linear regression, random forest, artificial neural network) to predict maximum postoperative lactate concentration, the prediction error ranged from a median of 2.52 mmol/L (IQR 2.46, 2.56) to 2.58 mmol/L (IQR 2.54, 2.60). The inclusion of intraoperative summary statistics (including intraoperative lactate concentration) improved model performance, with the prediction error ranging from a median of 2.09 mmol/L (IQR 2.04, 2.14) to 2.12 mmol/L (IQR 2.06, 2.16). For two modelling approaches (recurrent neural network, transformer) that can utilize intraoperative time-series data, the lowest prediction error was obtained with a range of median 1.96 mmol/L (IQR 1.87, 2.05) to 1.97 mmol/L (IQR 1.92, 2.05). Intraoperative lactate concentration was the most important predictive feature based on Shapley additive values. Anemia and weight were also important predictors, but there was heterogeneity in the importance of other features.ConclusionPostoperative lactate concentrations can be predicted using baseline and intraoperative data with moderate accuracy. These results reflect the value of intraoperative data in the prediction of clinically relevant outcomes to guide perioperative management.
Evaluation of macular neovascularization activity in pathological myopia: a comparison between optical coherence tomography and OCT-angiography
Authors: Li Xin , Jing Ruixia , Li Xue , Wang Zhen 
Published: September 2023

PurposeThe purpose of this study was to suggest a novel approach to assessing the activity of macular neovascularization (MNV) in pathological myopia (PM) by comparing optical coherence tomography (OCT) with OCT-angiography (OCT-A).MethodsThe Zeiss Cirrus HD-5000 was used to obtain OCT and OCT-A images of PM-MNV. The objective was to examine the characteristics of PM-MNV lesions and investigate the relationship between PM-MNV activity and changes in retinal structure in 54 patients (54 eyes). To analyze the OCT parameters associated with PM-MNV activity and their clinical significance in terms of sensitivity and specificity, we used OCT-A as a reference.ResultsThis study included 72 patients (72 eyes), of whom 54 had good image quality and were considered for analysis. The study evaluated various OCT characteristics of MNV lesions, including the elevation of an external limiting membrane (ELM), ellipsoidal zone (EZ), retinal pigment epithelium (RPE) elevation, and EZ/RPE interruption, to identify possible parameters associated with PM-MNV activity. The interobserver consistency was found to be almost perfect. In the evaluation of PM-MNV activity, the sensitivity of ELM elevation, EZ interruption, and RPE interruption was found to be 66.7% (low), 88.4% (high), and 95.6% (high), respectively. However, the specificity was found to be 71.4% (moderate), 71.4% (moderate), and 25.4% (poor), respectively. This indicates that the current evaluation methods are not accurately assessing PM-MNV activity. We developed a new comprehensive method that used EZ interruption as the primary parameter and ELM elevation and RPE interruption as secondary parameters to evaluate PM-MNV activity with a sensitivity of 97.8% and a specificity of 85.4%.ConclusionIn PM-MNV, a novel comprehensive diagnostic method combining EZ interruption, ELM elevation, and RPE interruption might be a valuable indicator to evaluate PM-MNV activity.