bluuebunny/crossref_metadata_2025_split huggingface dataset:
A scoping review of the unmet needs of patients diagnosed with idiopathic pulmonary fibrosis (IPF)
Authors: Bramhill Carita , Langan Donna , Mulryan Helen , Eustace-Cook Jessica , Russell Anne-Marie , Brady Anne-Marie 
Published: September 2023

AbstractTitleA scoping review of the unmet needs of patients diagnosed with idiopathic pulmonary fibrosis (IPF).AimsPatients diagnosed with IPF have a high symptom burden and numerous needs that remain largely unaddressed despite advances in available treatment options. There is a need to comprehensively identify patients’ needs and create opportunities to address them. This scoping review aimed to synthesise the available evidence and identify gaps in the literature regarding the unmet needs of patients diagnosed with IPF.MethodsThe protocol for the review was registered with Open Science Framework (DOI 10.17605/OSF.IO/SY4KM). A systematic search was performed in March 2022, in CINAHL, MEDLINE, Embase, PsyhcoInfo, Web of Science Core Collection and ASSIA Applied Social Science Index. A comprehensive review of grey literature was also completed. Inclusion criteria included patients diagnosed with IPF or PF; English language only and date range 2011-2022. A range of review types were included. Data was extracted using a data extraction form. Data was analysed using descriptive and thematic analysis. A total of 884 citations were reviewed. Ethical approval was not required.Results52 citations were selected for final inclusion. Five themes were identified: psychological impact of an IPF diagnosis; adequate information and education: at the right time and in the right way; high symptom burden support needs; referral to palliative care and advanced care planning (ACP) and health service provision-a systems approach.ConclusionThis review highlights the myriad of needs patients with IPF have and highlights the urgent need for a systems approach to care, underpinned by an appropriately resourced multi-disciplinary team. The range of needs experienced by patients with IPF are broad and varied and require a holistic approach to care including targeted research, coupled with the continuing development of patient-focused services and development of a clinical care programme.
Epidermal barrier dysregulation in atopic skin predisposes for excessive growth of the allergy-associated yeastMalassezia
Authors: Ruchti Fiorella , Zwicky Pascale , Becher Burkhard , Dubrac Sandrine , LeibundGut-Landmann Salomé 
Published: September 2023

ABSTRACTThe skin barrier is vital for protection against environmental threats including insults caused by skin-resident microbes. Dysregulation of the barrier is a hallmark of atopic dermatitis (AD) and ichthyosis, with variable consequences for host immune control of colonizing commensals and opportunistic pathogens. While sensitisation toMalassezia, the most abundant commensal fungus of the skin, is common in AD, its relevance for pathogenesis remains unclear. Here we show that in barrier-disrupted skin,Malasseziaacquires enhanced fitness. This is not a consequence of the dysregulated allergic immune status characteristic for AD but is rather explained by structural and metabolic changes in the cutaneous niche that provide increased accessibility and a favourable lipid profile, to which the lipid-dependent yeast adapts for enhanced nutrient assimilation. These findings reveal fundamental insights into the role of the mycobiota in the pathogenesis of common skin barrier disorders.
Targeting monocytic Occludin impairs monocyte transmigration and HIV neuroinvasion
Authors: Brychka Diana , Ayala-Nunez Nilda Vanesa , Bare Yonis , Dupas Amandine , Partiot Emma , Mittelheisser Vincent , Lucansky Vincent , Goetz Jacky G. , Osmani Nael , Gaudin Raphael 
Published: September 2023

AbstractTransmigration of circulating monocytes from the bloodstream toward the central nervous system (CNS) represents a hallmark of neuroinflammation and plays an important role during viral encephalitis and HIV-associated neurocognitive disorders (HAND). The molecular mechanisms involved in monocyte transmigration through endothelia has been extensively studied, but how monocytes locally unzip tight junction-associated proteins (TJAPs) of the endothelium composing the neurovascular unit (NVU) to reach the CNS remains poorly understood. Here, we show that human circulating monocytes express the TJAP Occludin (OCLN) to promote transmigration through cerebral microvessel endothelial cells. Silencing monocytic OCLN (mOCLN) impairs monocyte transmigration, while mOCLN overexpression increases transmigration. Using high-resolution live cell imaging, we observed that mOCLN clusters at the monocyte-endothelium interface during the transmigration process, forming a transient ring of mOCLN at the site of diapedesis. Furthermore, we designed OCLN-derived peptides targeting its extracellular loop (EL) 1 or 2 to prevent potential trans-homotypic interactions of mOCLN with endothelial OCLN. We found that transmigration of human monocytes was significantly inhibited upon treatment with the EL2 peptidein vitroand in zebrafish embryos, while preserving vascular integrity. Monocyte transmigration toward the brain is an important process for HIV neuroinvasion and here, we showed that the treatment of transmigrating monocytes with the EL2 peptide prevents the dissemination of HIV to cerebral organoids. In conclusion, our study identifies an important role for monocytic OCLN during transmigration and provides a proof-of-concept for the development of mitigation strategies to prevent HIV neuroinvasion.
The intervening influence of the quality of health-care administrative process on the relationship between facilities management service quality and patients’ health-care experience in Ghana
Authors: Amankwah Oti , Choong Weng Wai , Boakye-Agyeman Naana Amakie , Afrane Ebenezer 
Published: September 2023

Purpose
Patient-centred strategies should be applied in health-care facilities management (HcFM) to guarantee service quality to meet patients’ needs and ensure quality patient health-care experience. This paper aims to examine the intervening influence of the quality of health-care administrative process (QAP) on the association between health-care facilities service quality and patients’ experiences with medical care.

Design/methodology/approach
A quantitative technique was used for this cross-sectional study in three Ghanaian teaching hospitals. A total of 622 relevant questionnaires were used for the analysis of the study using SEM-PLS.

Findings
The intervening influence of the QAP on the relationship between HcFM service quality (empathy and tangibility) and patients’ health-care experience (PHcE) were reinforced whilst that of reliability, responsiveness and assurance were not reinforced. The association between the QAP and PHcE was also established.

Research limitations/implications
A high-quality health-care workforce (both core and supporting) and quality work environment provided by the FM department and QAP are essential during quality-of-care delivery, to reduce threats to patient safety to achieve exceptional PHcE. The constraint on the study is that information was gathered from only Ghana. Hence, the generalisation of the findings will be a challenge. Thus, in future, it is proposed that a comparative study across a developed country and a developing country can be conducted. Future research can assess the influence of the health-care internal appearance on patients’ satisfaction.

Practical implications
Practically, the administrative system can be improved by reducing patients overall waiting time. Steps must also be taken to reduce the problem of needless administrative tasks and practices to simplify administrative practices and improve patients’ total health-care experience (core health-care delivery and HcFM), as this influence patients’ total health-care experience.

Originality/value
To the best of the authors’ knowledge, this empirical validation is one of the initial studies in service quality and FM to examine how health-care administrative process quality affects the relationship between FM service quality and patients’ experiences with medical care. This framework can be adapted for research in different countries to extend knowledge.
Study on (3+1)-dimensional nonlocal Boussinesq equation: multiple soliton solutions
Authors: Wazwaz Abdul-Majid , Alshehri Mansoor , El-Tantawy Samir A. 
Published: September 2023

Purpose
This study aims to explore novel solitary wave solutions of a new (3 + 1)-dimensional nonlocal Boussinesq equation that illustrates nonlinear water dynamics.

Design/methodology/approach
The authors use the Painlevé analysis to study its complete integrability in the Painlevé sense.

Findings
The Painlevé analysis demonstrates the compatibility condition for the model integrability with the addition of new extra terms.

Research limitations/implications
The phase shifts, phase variables and Hirota’s bilinear algorithm are used to furnish multiple soliton solutions.

Practical implications
The authors also furnish a variety of numerous periodic solutions, kink solutions and singular solutions.

Social implications
The work formally furnishes algorithms for investigating several physical systems, including plasma physics, optical communications and oceans and seas, among others.

Originality/value
This paper presents an original work using a newly developed Painlevé integrable model, as well as novel and insightful findings.
A train timetable rescheduling approach based on multi-train tracking optimization of high-speed railways
Authors: Wang Rongsheng , Zhang Tao , Yuan Zhiming , Ding Shuxin , Zhang Qi 
Published: September 2023

PurposeThis paper aims to propose a train timetable rescheduling (TTR) approach from the perspective of multi-train tracking optimization based on the mutual spatiotemporal information in the high-speed railway signaling system.Design/methodology/approachFirstly, a single-train trajectory optimization (STTO) model is constructed based on train dynamics and operating conditions. The train kinematics parameters, including acceleration, speed and time at each position, are calculated to predict the arrival times in the train timetable. A STTO algorithm is developed to optimize a single-train time-efficient driving strategy. Then, a TTR approach based on multi-train tracking optimization (TTR-MTTO) is proposed with mutual information. The constraints of temporary speed restriction (TSR) and end of authority are decoupled to calculate the tracking trajectory of the backward tracking train. The multi-train trajectories at each position are optimized to generate a time-efficient train timetable.FindingsThe numerical experiment is performed on the Beijing-Tianjin high-speed railway line and CR400AF. The STTO algorithm predicts the train’s planned arrival time to calculate the total train delay (TTD). As for the TSR scenario, the proposed TTR-MTTO can reduce TTD by 60.60% compared with the traditional TTR approach with dispatchers’ experience. Moreover, TTR-MTTO can optimize a time-efficient train timetable to help dispatchers reschedule trains more reasonably.Originality/valueWith the cooperative relationship and mutual information between train rescheduling and control, the proposed TTR-MTTO approach can automatically generate a time-efficient train timetable to reduce the total train delay and the work intensity of dispatchers.
Does CSR digitalization improve the sustainable competitive performance of SMEs? Evidence from an emerging economy
Authors: Ahmad Maqsood , Wu Qiang , Ahmed Shakeel 
Published: September 2023

Purpose
This study aims to investigate the influence of the digitalization of corporate social responsibility (CSR) on the sustainable competitive performance (SCP) of small- and medium-sized enterprises (SMEs) in an emerging economy and to examine the moderating effect of digital organizational culture on this relationship.

Design/methodology/approach
Data collection was conducted through a survey completed by 311 owners and top managers operating in service, trading and manufacturing sector SMEs positioned within the twin cities of Pakistan. A convenient purposively sampling technique and snowball method were used for data collection, and structural equation modeling was used for data analysis.

Findings
The results of this study suggest that CSR digitalization has a markedly positive influence on the SCP. Digital organizational culture appears to moderate these relationships.

Practical implications
This study highlights the importance of considering CSR digitalization and fostering a digital organizational culture for SMEs to achieve SCP. The findings provide valuable insights for strategic decision-makers, including owners, CEOs and senior management of SMEs, to enhance their knowledge concerning how and why a digital organizational culture makes it easier to digitalize CSR activities, with the ultimate objective of ensuring SCP and SME growth. Overall, the findings of this study have practical implications for policymakers and managers in SMEs as they can promote the adoption of digital technologies in CSR initiatives and develop a digital organizational culture within the organization. This would contribute to enhancing the SCP of SMEs. Thus, this research is beneficial for business actors, policymakers and researchers seeking to enhance SMEs’ SCP.

Social implications
This study provides valuable guidance to the senior management of SMEs regarding successfully adopting and integrating digital technologies into their CSR practices. This integration can lead to increased social and environmental benefits, which positively impact both business and society. Policymakers can use these findings to develop policies and initiatives to encourage CSR digitalization among SMEs. By providing support and incentives for digital transformation, policymakers can help SMEs adopt digital tools to improve their CSR performance, contributing to economic growth and sustainability.

Originality/value
This study pioneers research on the links between CSR digitalization, digital organizational culture and the SCP of SMEs. This study contributes to the literature by defining CSR digitalization as an antecedent to the SCP of SMEs. In addition, this study underlines the significance of CSR digitalization for the achievement of SMEs’ SCP of SMEs with the moderating role of digital organizational culture. Overall, this study enriches the resource base view literature through empirical evidence.
Cu-Cu joint with Sn-58Bi/Porous Cu/Sn-58Bi transient liquid phase bonding under formic acid atmosphere
Authors: Xiong Bifu , He Siliang , Ge Jinguo , Li Quantong , Hu Chuan , Yan Haidong , Shen Yu-An 
Published: September 2023

Purpose
This paper aims to examine the effects of bonding temperature, bonding time, bonding pressure and the presence of a Pt catalyst on the bonding strength of Cu/SB/P-Cu/SB/Cu joints by transient liquid phase bonding (TLPB).

Design/methodology/approach
TLPB is promising to assemble die-attaching packaging for power devices. In this study, porous Cu (P-Cu) foil with a distinctive porous structure and Sn-58Bi solder (SB) serve as the bonding materials for TLPB under a formic acid atmosphere (FA). The high surface area of P-Cu enables efficient diffusion of the liquid phase of SB, stimulating the wetting, spreading and formation of intermetallic compounds (IMCs).

Findings
The higher bonding temperature decreased strength due to the coarsening of IMCs. The longer bonding time reduced the bonding strength owing to the coarsened Bi and thickened IMC. Applying optimal bonding pressure improved bonding strength, whereas excessive pressure caused damage. The presence of a Pt catalyst enhanced bonding efficiency and strength by facilitating reduction–oxidation reactions and oxide film removal.

Originality/value
Overall, this study demonstrates the feasibility of low-temperature TLPB for Cu/SB/P-Cu/SB/Cu joints and provides insights into optimizing bonding strength for the interconnecting materials in the applications of power devices.
An innovative method for human height estimation combining video images and 3D laser scanning
Authors: Ciampini Claudio , Petrillo Antonella , Zomparelli Federico , Groutas Stefano 
Published: September 2023

AbstractDigitalization has increased the number of video surveillance systems that sometimes capture crime images. Traditional methods of human height estimation use projective geometry. However, sometimes they cannot be used because the video camera surveillance system is not available or has been moved and there are no reference lines on the frame. Scientific studies have developed a new method for human height estimation using 3D laser scanning. This model necessarily requires a series of approximations, which increase the final measurement error. To overcome this problem, in the present study, images of a subject are projected directly on the 3D model, estimating the height of the subject. This article describes the methodological approach adopted through the analysis of a real case study in a controlled environment executed by Carabinieri Forensic Investigation Department (Italy). The aim is to obtain a human anthropometric measure derived from frames extracted from the videos associated with the digital survey of the framed area obtained with 3D laser scanning and point cloud analysis. The result is the height estimation of five subjects filmed by a camera obtained through the combination of 2D images extracted by a DVR/surveillance systems with 3D laser scanning. Results show that most estimated measurements are less than the real measurement of the subject; it also depends on the posture of the subject while walking. Furthermore, results shows the differences between the real height and the estimated height with a statistical approach.
Eco‐parcel: An approach to identify and describe attractions to support adapting nature‐based tourism destinations to climate‐change impacts
Authors: Kilungu Halima , Munishi Pantaleo K. 
Published: September 2023

AbstractInforming climate‐change adaptation measures for nature‐based tourism destinations is contingent on understanding how individual attractions respond to the impact of climate change. There is, however, no evidence of the existence of specific approaches for linking individual attractions to climate change. The eco‐parcel approach is therefore devised to address the gap. The approach follows three simple steps: (1) identifying and defining individual tourist attractions (2) describing and creating a link between individual attractions and their supporting ecosystems using land cover as a proxy; (3) assessing the importance of discrete landscape patches (eco‐parcels) for tourism. The three steps employ literature reviews, tourists' preference surveys and GIS data collection techniques. The operationalisation of the approach in Tanzanian Serengeti and Kilimanjaro National parks case studies shows that the approach is capable of establishing a list of attractions that a destination has and creating spatial–temporal links between attractions and their supporting ecosystems. In conclusion, the eco‐parcel approach allows accurate assessment of the likely losses or gains of individual attractions in the event of climate change, providing information on destination‐specific climate adaptation strategies and, thus, a useful tool for adapting NBT to climate‐change impacts.
Differentiation of human primary testicular cells in the presence of SCF using the organoid culture system
Authors: Nikmahzar Aghbibi , Koruji Morteza , Jahanshahi Mehrdad , Khadivi Farnaz , Shabani Maryam , Dehghani Sanaz , Forouzesh Mehdi , Jabari Ayob , Feizollahi Narjes , Salem Maryam , Ghanami Gashti Nasrin , Abbasi Yasaman , Abbasi Mehdi 
Published: September 2023

AbstractPurposeDevelopment of organoids using human primary testicular cells has remained a challenge due to the complexity of the mammalian testicular cytoarchitecture and culture methods. In this study, we generated testicular organoids derived from human primary testicular cells. Then, we evaluated the effect of stem cell factor (SCF) on cell differentiation and apoptosis in the testicular organoid model.MethodsThe testicular cells were harvested from the three brain‐dead donors. Human spermatogonial stem cells (SSCs) were characterized using immunocytochemistry (ICC), RT‐PCR and flow cytometry. Testicular organoids were generated from primary testicular cells by hanging drop culture method and were cultured in three groups: control group, experimental group 1 (treated FSH and retinoic acid (RA)), and experimental group 2 (treated FSH, RA and SCF), for five weeks. We assessed the expression of SCP3 (Synaptonemal Complex Protein 3) as a meiotic gene, PRM2 (Protamine 2) as a post‐meiotic marker and apoptotic genes of Bax (BCL2‐Associated X Protein) and Bcl‐2 (B‐cell lymphoma 2), respectively by using RT‐qPCR. In addition, we identified the expression of PRM2 by immunohistochemistry (IHC).ResultsRelative expression of SCP3, PRM2 and Bcl‐2 were highest in group 2 after five weeks of culture. In contrast, BAX expression level was lower in experimental group 2 in comparison with other groups. IHC analyses indicated the highest expression of PRM2 as a postmeiotic marker in group 2 in comparison to 2D culture and control groups but not find significant differences between experimental group 1 and experimental group 2 groups. Morphological evaluations revealed that organoids are compact spherical structures and in the peripheral region composed of uncharacterized elongated fibroblast‐like cells.ConclusionOur findings revealed that the testicular organoid culture system promote the spermatogonial stem cell (SSC) differentiation, especially in presence of SCF. Developed organoids are capable of recapitulating many important properties of a stem cell niche.
When DNA can't help: The osteobiographical profile and stable isotope analysis as auxiliary tools for refining genealogical relationships, on the example of the Swéerts‐Sporck family
Authors: Cvrček Jan , Drtikolová Kaupová Sylva , Vytlačil Zdeněk , Zazvonilová Eliška , Velemínský Petr 
Published: September 2023

AbstractResearch into the family of the Counts Swéerts‐Sporck raised doubts regarding their biographical data, particularly concerning a child who died in 1817, later identified as Philipp Swéerts‐Sporck, and his siblings Joseph and Barbara. These were alleged to include a pair of dizygotic twins, but DNA could not be used to clarify their relationships. Carbon and nitrogen isotopes were therefore measured in their first permanent molars, whereas Philipp's biological age was estimated based on his skeleton. Philipp died at an older age than the written sources claim; an isotopic similarity was found between Joseph and Barbara, but Philipp differed.