bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KINERJA PENGELOLAAN KEUANGAN DAERAH PROVINSI MALUKU
Authors: Marselina Dona , Soselia Kimberly Emma , Ningrum Cerafika Sri , Pangestu Novaldo Fardinan , Lero Agnes Febrina , Kristanti Putriana 
Published: May 2023

ABSTRACT This study aims to analyze the regional financial performance of Maluku Province from 2019 to 2021. The research method uses descriptive statistical analysis. The analysis tool uses the measurement of independence ratio, effectiveness ratio, efficiency ratio, activity ratio, and growth ratio. This study analyzes the results of the data management obtained. The data used is historical data, namely secondary data in the form of published regional government financial reports. The findings show that the financial management performance of the Maluku Province in terms of the level of independence is very low with a pattern of instructive relationships with very effective and efficient management, an unbalanced activity ratio between operating expenditures and capital expenditures, and very low growth. Recommendations for the regional government of the Maluku Province to increase the budget and realization of their own regional income, so that the level of independence, effectiveness, efficiency, activity, and growth increases. Keywords: Area, Finance, Maluku Province, Management, Performance. ABSTRAK Penelitian ini bertujuan untuk menganalisis kinerja keuangan daerah Provinsi Maluku pada tahun 2019 sampai dengan tahun 2021. Metode penelitian menggunakan analisis statistik deskriptif. Alat analisis menggunakan pengukuran rasio kemandirian, rasio efektivitas, rasio efisiensi, rasio aktivitas, dan rasio pertumbuhan. Penelitian ini menganalisis hasil pengelolaan data yang diperoleh. Data yang digunakan merupakan data historis, yaitu data sekunder berupa laporan keuangan pemerintah daerah yang dipublikasikan. Temuan menunjukkan bahwa kinerja pengelolaan keuangan Provinsi Maluku dalam hal tingkat kemandirian rendah sekali dengan pola hubungan instruktif dengan pengelolaan yang sangat efektif, efisien, rasio aktivitas yang belum seimbang antara belanja operasi dengan belanja modal, dan pertumbuhan yang sangat rendah. Rekomndasi bagi pemerintah daerah Provinsi Maluku untuk meningkatkan anggaran dan realisasi pendapatan asli daerahnya, supaya tingkat kemandirian, efektifitas, efisiensi, aktivitas, dan pertumbuhan naik, membuat kebijakan dalam pengelolaan keuangan daerah yang dapat memberikan dampak positif kesejahteraan masyarakat. Kata kunci: Daerah, Keuangan, Kinerja, Pengelolaan, Provinsi Maluku
Does knowledge and brand image affect the intention to save in Islamic banks?
Authors: Adiyati Alfi Khaerah , Arwiyanah Arwiyanah , Baharuddin Jukri , Affandy Fachrudin Fiqry , Firdaus Muhammad Anang 
Published: May 2023

Purpose- This study aims to determine the effect of knowledge and brand image variables related to the interest of IAIN Fattahul Muluk Papua students in saving at Islamic banks. Method- This research is a quantitative research using multiple regression analysis method with two X variables and one Y variable and the data in this study were obtained from 62 students who were collected through questionnaires distributed. Result- The results of the study show that knowledge and brand image have a significant effect on students' interest in saving at Islamic banks. Implication- This research has implications for increasing students' knowledge of Islamic banks by providing courses that are directly integrated into the application of products and services in Islamic banks. Furthermore, to increase the brand image of Islamic banks among students, they can continue to collaborate between the two institutions. Originality- This study looks directly at the influence of knowledge and brand image by students which will be able to influence them to save at Islamic banks. Considering that there are not too many Islamic banks in the province of Papua and they are still very new.
Risk analysis of meteorological, agricultural, and hydrological drought events and study of drought propagation features: a case study in the upper Tapti River sub-basin, Central India
Authors: Kanthavel P. , Saxena C. K. , Singh R. K. 
Published: May 2023

Abstract
As a natural hazard, drought is a complex multivariate phenomenon that requires more comprehensive analysis. In this study, we studied meteorological, agricultural, and hydrological drought events with precipitation, soil moisture, and stream flow data for the study area. The risk analysis for drought duration and severity of three kinds of drought events were analyzed with univariate and three kinds of bivariate return periods based on the copula. Furthermore, the propagation of three kinds of drought was studied. From the investigation, it is observed that agricultural drought events are longer and more severe, besides the risk associated with agricultural drought is high compared to other kinds of drought. Moreover, the average time taken for meteorological drought to propagate into agricultural drought is 4.3 months and for the hydrological drought is 3.8 months for the river basin. The comprehensive study of three kinds of drought is helpful to adopt suitable drought management plans in the region.
Network Pharmacology and Intestinal Microbiota Analysis Revealing the
Mechanism of Punicalagin Improving Bacterial Enteritis
Authors: Huang Shuyun , Wang Ying , Zhu Qingsong , Guo Hongmin , Hong Zongyuan , Zhong Shuzhi 
Published: May 2023

Background:
The Chinese medicine punicalagin (Pun), the most important active ingredient
in pomegranate peel, has significant bacteriostatic and anti-inflammatory properties. The
potential mechanisms of Pun for bacterial enteritis, however, are unknown.

Objective:
The goal of our research is to investigate the mechanism of Pun in the treatment of bacterial
enteritis using computer-aided drug technology, as well as to investigate the intervention
effect of Pun on mice with bacterial enteritis using intestinal flora sequencing.

Methods:
The targets of Pun and Bacterial enteritis were obtained by using the specific database,
and cross-targets were screened among these targets, followed by PPI and enrichment analysis of
the targets. Furthermore, the degree of binding between Pun and key targets was predicted through
molecular docking. After successfully establishing the bacterial enteritis model in vivo, mice were
randomly assigned to groups. They were treated for 7 days, the symptoms were observed daily,
and the daily DAI and body weight change rate were calculated. Following administration, the
intestinal tissue was removed, and the contents were separated. The tight junction protein expression
was detected in the small intestine by the immunohistochemical method; ELISA and Western
Blot (WB) were performed to detect the expressions of tumor necrosis factor-α (TNF-α) and interleukin-
6 (IL-6) in the serum and intestinal wall of mice. The 16S rRNA sequence was used to determine
the composition and diversity of the intestinal flora of mice.

Results:
In total, 130 intersection targets of Pun and disease were screened by network pharmacology.
The enrichment analysis showed cross genes were closely related and enriched in the cancer
regulation and the TNF signal pathway. The active components of Pun could specifically bind
to the core targets TNF, IL-6, etc., determined from molecular docking results. In vivo experiment
results showed that the symptoms in the PUN group mice were alleviated, and the expression levels
of TNF-α and IL-6 were significantly reduced. A Pun can cause substantial changes in the intestinal
flora of mice in terms of structure and function.

Conclusion:
Pun plays a multi-target role in alleviating bacterial enteritis by regulating intestinal flora.
Recent Advancements and Applications of Size Exclusion Chromatography
in Modern Analysis
Authors: Bhatia Rohit , Kumari Yogindra , Chopra Arshdeep 
Published: May 2023

Abstract:
In recent years, size exclusion chromatography (SEC) has gained valuable and impactable
recognition among various chromatographic techniques. Also addressed as other names, viz. gel permeation
chromatography, steric-exclusion chromatography, etc., SEC is typically taken into consideration for
the fractionation and molecular weight determination of biomolecules and large macromolecules (proteins
and polymers) using porous particles. A homogenous mixture of molecules dispersed in the mobile phase
is introduced to the chromatographic column, which provides a solid support in the form of microscopic
beads (the stationary phase). The beads act as “sieves” and purify small molecules, which become temporarily
trapped inside the pores. Some of the advantages that SEC offers over other chromatographic techniques
are short analysis time, no sample loss, good sensitivity, and requirement for less amount of mobile
phase. In the proposed manuscript, we have deliberated various proteomic applications of size exclusion
chromatography, which include the isolation of extracellular vesicles in cancer, isolation of human
synovial fluid, separation of monoclonal antibodies, as well as several tandem techniques, such as deep
glycoproteomic analysis using SEC-LC-MS/MS, analysis of mammalian polysomes in cells and tissues
using tandem MS-SEC, SEC-SWATH-MS profiling of the proteome with a focus on complexity, etc.
Secrecy Performance Review for IoT-based Cognitive Farming System
Authors: Chopra Khyati , Alam M. Afshar 
Published: May 2023

Abstract:
Smart farm management has complex challenges; therefore, there is a need to improve
the overall adaptability, profitability, and environmental soundness of the farming systems. Agricultural
production can be enhanced with the help of IoT-based cognitive tools. The rapid increase
in IoT-based smart systems has raised critical concerns about efficiently utilizing the wireless spectrum.
To drastically bring the improvement in the utilization of the wireless spectrum, cognitive radio
(CR) has emerged as an effective solution. The inherent openness and broadcast nature of the
wireless medium have given rise to many security issues in cooperative networks. Informationtheoretic
security or physical layer security (PLS) is evolved as an efficacious wireless prototype
for reliable transmissions to avert the eavesdropper from expropriating transmittal data on the wireless
connections. Security is the key factor in these networks as they are exposed and active in behavior,
thus, are susceptible to fraudulent activities. We investigated the performance of the CR
system in terms of secrecy and also examined the system in terms of diversity receipt and selection
of relay. The secrecy outcome of channel state information at the sender was also studied. The detrimental
effects of fading in cooperative networks were also extensively discussed. Cooperative diversity
was examined by deploying MRC and SC strategies at receptors. It has been deduced that CSI
knowledge at the sender also has an eloquent concussion on the secrecy of the cognitive system.
Preparation and Evaluation of Medicated Formulation for Dry Eye
Authors: Singh Nishita , Maurta Rahul , Mishra Sudhanshu , Jain Deepti 
Published: May 2023

Introduction:
The current research involved the study of chondroitin sulfate polymer to prevent
moisture loss, which was formulated to treat dry eye.

Methods:
The ophthalmic formulation was prepared with 5% liquid paraffin wax, 10% carbowax, and 1%
glycerine. Furthermore, its usefulness in ophthalmology was analyzed by measuring parameters like pH,
isotonicity, turbidity, viscosity, % moisture loss, vapor pressure, and in-vitro and in-vivo corneal damage.

Results:
We successfully adjusted the pH and osmolality of the F2 formulation to the desired physiological
levels, providing the opportunity to reduce the harmful reaction as well as inflammation and dehydration.
In addition, viscosity plays an important role in ophthalmic preparation. Consequently, the stability
studies of optimized formulation indicated no remarkable changes in physical properties, including pH,
viscosity, phase separation, and turbidity. Furthermore, a vapor pressure manometer studied the percentage
of moisture loss. Interestingly, the HET-CAM test correlated properly with the findings of the Draize
eye inflammation test. Moreover, the in-vivo irritation test of the optimized system showed that it was
tolerable, with no signs of irritation in the rabbit eye compared to the marketed formulation. In addition,
the F2 formulation demonstrated better results than the marketed corneal preparation. Thereby, from the
results, it can be concluded that the simple manometer apparatus can be the best method for evaluating
moisture loss prevention for dry eyes. No study or investigation has been reported before for ophthalmic
preparation.

Conclusion:
Altogether, chondroitin sulfate with carbowax 1000 and liquid paraffin-based ophthalmic
preparation can be considered a promising approach for preventing dryness of the eye.
Soluble Interleukin-2 Receptor Level in Hypertensive Patients with COVID-19-associated Pneumonia
Authors: Skakun Oleksii , Seredyuk Nestor , Fedorov Sergiy , Verbovska Olha 
Published: May 2023

Introduction. Soluble interleukin-2 receptor (sIL-2R) is considered to be an important biomarker that reflects the condition of patients with COVID-19. The establishment of its predictive ability in hypertensive patients with COVID-19-associated pneumonia is perspective.
Aim. This study aimed to evaluate of serum sIL-2R level and to establish its predictive ability for severe/critical clinical condition and mortality in patients with COVID-19-associated pneumonia and arterial hypertension.
Materials and methods. 135 unvaccinated adult patients hospitalized for COVID-19-associated pneumonia were enrolled in the study. 106 (78.5%) patients were hypertensive.
Results. There was higher median serum sIL-2R level at hospital admission in hypertensive patients (5.87 [4.51–8.16] ng/mL) than in non-hypertensive patients (4.99 [3.56–6.14] ng/mL) (p=0.037). There was no statistically significant difference in sIL-2R levels at admission in patients with moderate, severe and critical clinical conditions among hypertensive patients (p=0.171 according to the Kruskal-Wallis test). But among non-hypertensive patients, serum sIL-2R was higher in patients with severe condition (5.73 [4.90–8.90] ng/mL) than in patients with moderate condition (3.87 [2.71–5.37] ng/mL) (p=0.041 according to the Kruskal-Wallis test, post-hoc Dunn’s test: p=0.012). There was no statistically significant difference in the median serum sIL-2R level between non-survivors (7.80 [5.96–9.94] ng/mL) and survivors (5.62 [4.29–7.71] ng/mL) (p=0.066). In hypertensive patients, serum sIL-2R level failed to predict in-hospital mortality (AUC=0.664, p=0.075), development of severe/critical clinical conditions (AUC=0.583, p=0.138), and need for supplemental oxygen (AUC=0.589, p=0.121).
Conclusions. Hypertensive patients have higher serum sIL-2R levels at hospital admission than non-hypertensive patients. There is no statistically significant association between sIL-2R level at hospital admission and disease severity or in-hospital mortality in hypertensive patients. sIL-2R level at hospital admission failed to predict in-hospital mortality, development of severe/critical conditions, and need for supplemental oxygen in hypertensive patients. sIL-2R level is suggested to have the poor predictive ability in hypertensive patients.
Keywords: COVID-19, hypertension, sIL-2R, prediction, pneumonia.
Conceptualizing Interprofessional Digital Communication and Collaboration in Health Care: Protocol for a Scoping Review
Authors: Nordmann Kim , Sauter Stefanie , Möbius-Lerch Patricia , Redlich Marie-Christin , Schaller Michael , Fischer Florian 
Published: May 2023

Background
Effective communication and collaboration among health professionals are essential prerequisites for patient-centered care. However, interprofessional teams require suitable structures and tools to efficiently use their professional competencies in the service of high-quality care appropriate to the patient’s life situation. In this context, digital tools potentially enhance interprofessional communication and collaboration and lead to an organizationally, socially, and ecologically sustainable health care system. However, there is a lack of studies systematically assessing the critical factors for successfully implementing tools for digitally supported interprofessional communication and collaboration in the health care setting. Furthermore, an operationalization of this concept is missing.

Objective
The aim of the proposed scoping review is to (1) identify factors influencing the development, implementation, and adoption processes of digital tools for interprofessional communication in the health care sector and (2) analyze and synthesize the (implicit) definition, dimensions, and concepts of digitally supported communication and collaboration among health care professionals in the health care setting. Studies focusing on digital communication and collaboration practices among health care professionals, including medical doctors and qualified medical assistants, in any health care setting will be included in this review.

Methods
To address these objectives, an in-depth analysis of heterogeneous studies is needed, which is best achieved through a scoping review. Within this proposed scoping review, which adheres to the Joanna Briggs Institute methodology, 5 databases (SCOPUS, CINAHL, PubMed, Embase, and PsycInfo) will be searched for studies assessing digital communication and collaboration among various health care professionals in different health care settings. Studies focusing on health care providers or patient interaction through digital tools and non–peer-reviewed studies will be excluded.

Results
Key characteristics of the studies included will be summarized through descriptive analysis, using diagrams and tables. We will synthesize and map the data and conduct a qualitative in-depth thematic analysis of definitions and dimensions of interprofessional digital communication and collaboration among health care and nursing professionals.

Conclusions
Results from this scoping review may help in establishing digitally supported collaborations between various stakeholders in the health care setting and successfully implementing new forms of interprofessional communication and collaboration. This could facilitate the transition to better coordinated care and encourage the development of digital frameworks.

International Registered Report Identifier (IRRID)
PRR1-10.2196/45179
Impact of Social Reference Cues on Misinformation Sharing on Social Media: Series of Experimental Studies
Authors: Jones Christopher M , Diethei Daniel , Schöning Johannes , Shrestha Rehana , Jahnel Tina , Schüz Benjamin 
Published: May 2023

Background
Health-related misinformation on social media is a key challenge to effective and timely public health responses. Existing mitigation measures include flagging misinformation or providing links to correct information, but they have not yet targeted social processes. Current approaches focus on increasing scrutiny, providing corrections to misinformation (debunking), or alerting users prospectively about future misinformation (prebunking and inoculation). Here, we provide a test of a complementary strategy that focuses on the social processes inherent in social media use, in particular, social reinforcement, social identity, and injunctive norms.

Objective
This study aimed to examine whether providing balanced social reference cues (ie, cues that provide information on users sharing and, more importantly, not sharing specific content) in addition to flagging COVID-19–related misinformation leads to reductions in sharing behavior and improvement in overall sharing quality.

Methods
A total of 3 field experiments were conducted on Twitter’s native social media feed (via a newly developed browser extension). Participants’ feed was augmented to include misleading and control information, resulting in 4 groups: no-information control, Twitter’s own misinformation warning (misinformation flag), social cue only, and combined misinformation flag and social cue. We tracked the content shared or liked by participants. Participants were provided with social information by referencing either their personal network on Twitter or all Twitter users.

Results
A total of 1424 Twitter users participated in 3 studies (n=824, n=322, and n=278). Across all 3 studies, we found that social cues that reference users’ personal network combined with a misinformation flag reduced the sharing of misleading but not control information and improved overall sharing quality. We show that this improvement could be driven by a change in injunctive social norms (study 2) but not social identity (study 3).

Conclusions
Social reference cues combined with misinformation flags can significantly and meaningfully reduce the amount of COVID-19–related misinformation shared and improve overall sharing quality. They are a feasible and scalable way to effectively curb the sharing of COVID-19–related misinformation on social media.
Efficacy of Naprapathy in Brachial Plexus Injury: Protocol for a Randomized Clinical Trial
Authors: Xiao Bin , Zhao Lishu , Huang Yong , Ma Anqi , Pei Baoshun , Li Zhengyu , Gu Fei 
Published: May 2023

Background
Clinical rehabilitation for brachial plexus injury is difficult in terms of chronic pain and dysfunction. Physiotherapy is considered a routine intervention for rehabilitation. Common physical therapy may require a variety of instruments. One approach that does not need instruments, but belongs to the field of complementary and alternative medicine, is naprapathy. Naprapathy, also called Tuina in China, has been applied in rehabilitation after brachial plexus injury for a long time. Naprapathy can relieve chronic neuropathic pain, promote local blood circulation, and improve body edema. Naprapathy can passively help improve motor functions in patients with peripheral nerve injury. However, the efficacy of naprapathy in improving rehabilitation after brachial plexus injury is unclear.

Objective
This study aims to evaluate the additional value of naprapathy when combined with conventional physical therapy for the treatment of brachial plexus injury.

Methods
This will be a single-center randomized controlled trial. A total of 116 eligible patients with brachial plexus injury will be randomly divided into an experimental group (naprapathy plus physical therapy group) or a control group (physical therapy group). The participants will be followed up for 4 weeks of treatment. Observation outcomes will include the visual analog scale score, upper limb index, electromyography findings, and adverse reactions, among others. The measuring points for outcomes will be the baseline and the completion of treatment. In addition, a quality control group independent from the research team will be set up to control the quality of the trial. Finally, the data will be analyzed using SPSS software (version 21.0; IBM Corp).

Results
The study is recruiting participants. The first participant was enrolled in September 2021. As of January 2023, a total of 100 participants have been enrolled. The trial is expected to be completed by September 2023. The study protocol was approved by the Ethics Review Committee of Yue Yang Hospital affiliated with the Shanghai University of Traditional Chinese Medicine (2021-012).

Conclusions
One limitation of this trial is that we will be unable to achieve strict double-blinding because of the features of naprapathy. The trial aims to contribute reliable evidence for decision-making in naprapathy for treating brachial plexus injury.

Trial Registration
Chinese Clinical Trial Registry ChiCTR2100043515; http://www.chictr.org.cn/showproj.aspx?proj=122154

International Registered Report Identifier (IRRID)
DERR1-10.2196/46054