bluuebunny/crossref_metadata_2025_split huggingface dataset:
Анализ случаев неиммунной водянки новорожденных детей
Authors: Елюбаева Д.Б. , Сулейменова И.Е. , Плужникова Е.А. , Cултанова С.Б. , Божбанбаева Н.С. , Исаева Х. 
Published: June 2023

Актуальность: В настоящее время на долю неиммунной водянки плода (НВП) приходится 80-85% всех выявленных водянок плода, оставшиеся 10-15% связаны с аллоиммунизацией эритроцитов и определяются как изоиммунизация плода. Несмотря на достижения последних лет в области перинатологии и неонатологии, НВП все же остается патологией, характеризующейся высокой летальностью, как в антенатальном, так и в постнатальном периоде. Выживаемость детей с данной патологией, по различным данным, составляет от 27 до 36%.
Цель исследования – провести анализ случаев неиммунной водянки плода, родившихся в Центре перинатологии и детской кардиохирургии (Алматы) за период с января 2019 по декабрь 2022 года для оптимизации ведения данного контингента больных.
Материалы и методы: Проведен ретроспективный анализ 8 случаев НВП у новорожденных, находившихся в Отделении реанимации и интенсивной терапии для новорожденных “Центра перинатологии и детской кардиохирургии” (Алматы, Казахстан) с января 2019 г. по декабрь 2022 г. Изучены течение беременности и анамнез матерей, данные клинико-лабораторных и инструментальных исследований всех случаев НВП.
Результаты: Этиология НВП была установлена во всех 8 (100%) случаях. Летальный исход составил 62,5% за счет множественных пороков развития, тяжелых комбинированных пороков сердца и генетических патологий, выживаемость – 37,5%.
Заключение: При НВП необходим комплексный диагностический подход, включающий следующие обследования плода: УЗИ, Эхо-КГ, кариотипирование для ранней диагностики. После рождения ребенка требуется мультидисциплинарный подход с вовлечением комплексных методов диагностики и назначением патогенетического и посиндромного лечения, которое будет способствовать повышению выживаемости новорожденных.
Опыт применения простагландинов Е1-Е2 с целью индукции родов
Authors: Бищекова Б.Н. , Кожабекова Т.А. , Рахимова С.Б. , Тлеукул Н.А. , Рахимов А.Е. 
Published: June 2023

Актуальность: В последние годы наблюдается увеличение частоты индукции родов. В развитых странах индуцируют 25% от общего числа родов при доношенной и 20-30% при недоношенной беременности. Своевременная и правильная оценка готовности к родам («зрелости») шейки матки важна для определения прогноза предстоящих родов, и в частности, показаний и сроков индукции родов.
Цель исследования – сравнить эффективность и безопасность применения перорального мизопростола и вагинального динопростона для индукции родов в сроке 37-41 (±4 дня) недель беременности.
Материалы и методы: Проведено проспективное исследование данных 160 беременных, поступивших в городской родильный дом №5 г. Алматы в 2021-2022 гг. и родоразрешенных путем преиндукции/индукции родов. Основную группу составили беременные, применявшие мизопростол перорально (n=110), группа сравнения – женщины, которым вводили динопростон гель вагинально (n=50).
Результаты: Основными показаниями для индукции родов были: тенденция к перенашиванию (49,1% против 42,0% р=0.05), гипертензивные состояния (22,7% против 24,0% р=0.05), задержка роста плода (14,6% против 16,0% р=0.05) и маловодие – 13,6% против 18,0% р=0.05). Средняя доза мизопростола у первородящих составила 125-150 мкг, у повторнородящих 100-125 мкг. Динопростон гель (1 мг) вводился в задний свод влагалища. При необходимости через 6 часов вводилась вторая доза геля: 1-2 мг.
На фоне приема препаратов регулярная родовая деятельность развилась у 81,8% против 80,0% (р=0.05), самопроизвольные роды произошли у 88,2% против 90,0% (р=0.05) рожениц, т.е. существенной разницы в способе родоразрешения в зависимости от метода индукции не выявлено.
Заключение: Таким образом, своевременная подготовка шейки матки к родам путем перорального применения мизопростола (простагландина Е1) и динопростона (Простагландина Е2) является эффективным методом преиндукции родов. Практическая значимость данного исследования позволит более активно внедрять в практику методы индукции родов, а именно – пероральное и вагинальное применение простагландинов Е1 и Е2, в соответствии с действующими протоколами диагностики и лечения.
E-Cybernetique: Etika Berinternet Dalam Bersosial Media Bagi Anak-Anak Sekolah Dasar Di Pekon Suka Maju Kecamatan Ngaras Kabupaten Pesisir Barat Provinsi Lampung
Authors: Putri Intan , Mulyadi Ahmad Iman , Adli  , Dendi  , Nanda Syukerti  
Published: June 2023

The ethics of communicating on social media in using social media. The more technology develops, the more rapidly social media is in today's world, so that we can get to know media communication, namely in this study through social media. In using social media, of course you can't go around like that, but there are communication ethics that need to be considered, in using social media.
The use of the internet is indeed very helpful and relieves solving problems in everyday life. There is a positive side and a negative side. Therefore, parents and teachers have a very important role in supervising and directing their children in using the internet. Children can choose positive internet content. Indeed, there must be collaboration in instilling knowledge about internet use by separating oneself from negative things.
Currently the internet is very global in human life, especially in children. For them, the internet is really needed in completing many tasks, but it turns out that the internet also has negative effects on them. Moreover, elementary school age children who do not have mental maturity, are immature in acting and thinking, so they are easily swept up by the currents of globalization.
IDENTITAS DAN KARAKTER SUKU BAJO DI TOROSIAJE DI TENGAH ARUS GLOBALISASI
Authors: Yunus Rasid , Kamuli Sukarman , Ngiu Zulaecha 
Published: June 2023

Globalisasi berdampak pada terkikisnya kearifan lokal yang kaya akan nilai-nilai karakter positif. Hal demikian terjadi pula pada Suku Bajo di Torosiaje. Olehnya, sangatlah diperlukan upaya mendalam dan konstruktif untuk menjaga agar karakter positif Suku Bajo di Torosiaje benar-benar eksis. Adapun metode penelitian yang digunakan yakni metode kualitatif. Hasil penelitian menunjukkan bahwa identitas dan karakter Suku Bajo di Torosiaje nampak pada kegiatan karakter religius yang ditandai dengan secara kuantitas beragama muslim, terbuka dengan orang lain, dan cinta lingkungan. Karakter gotong-royong nampak pada bersama-sama membangun rumah warga. Karakter inovatif nampak pada mulai mengenal kegiatan ekonomi daratan dan membangun wisata terapung yang yang menonjolkan identitas Suku Bajo di Torosiaje. Berdasarkan temuan tersebut disarankan beberapa hal seperti pentingnya memadukan identitas dan karakter Suku Bajo di Torosiaje dengan tuntutan dan perkembangan zaman, agar identitas dan karakter Bajo di Torosiaje tetap terjaga meskipun di tengah perubahan akibat globalisasi.
Gebeliğin intrahepatik kolestazında hastalığın şiddeti ve tedaviye yanıtın perinatal sonuçlara etkisi
Authors: OKUDAN Ebru , AKALIN Münip , DEMİRCİ Oya 
Published: June 2023

Amaç: Gebeliğin intrahepatik kolestazı (GİHK) ile komplike olan gebeliklerde, serum safra asiti (SA) düzeyleri ve ursodeoksikolik asit (UDKA) tedavisine verilen cevabın perinatal sonuçlar üzerine etkisini araştırmaktır.
Gereçler ve Yöntem: Bu çalışmada Ocak 2013 ile Ocak 2018 tarihleri arasında üçüncü basamak bir merkezde GİHK nedeniyle takip edilen gebelikler retrospektif olarak analiz edildi. GİHK şiddeti, serum SA seviyelerine göre hafif (10–40 μmol/L), orta (40-80 μ mol/L) ve şiddetli (>80 μ mol/L) olarak gruplandırıldı. GİHK’nın şiddeti ve UDKA tedavisine verilen olumlu veya olumsuz yanıtın perinatal sonuçlar üzerine etkisi araştırıldı.
Bulgular: GİHK tanısı koyulan toplamda 200 gebe çalışmaya dahil edildi. Hastaların %65 (n=130)’inde hafif GİHK, %20 (n=40)’sinde orta şiddetli GİHK ve %15 (n=30)’inde şiddetli GİHK saptandı. GİHK tanısıyla takip edilen hastaların 4 (%2.0)’ünde ölü doğum gerçekleşti. Şiddetli GİHK hastalarında spontan preterm doğum oranı, orta ve hafif GİHK hastalarına kıyasla anlamlı olarak daha yüksekti (p=0.001). Şiddetli GİHK hastalarında ve UDKA tedavisine yanıt vermeyen hastalarda, ortalama doğum haftası, ortalama doğum ağırlığı, 1. ve 5. dakika Apgar skorları daha düşük, amniyosta mekonyum varlığı, yenidoğan yoğun bakım ünitesi ihtiyacı ve ölü doğum oranları daha yüksekti.
Sonuç: GİHK ile komplike olan gebelikler fetal ve neonatal olumsuz sonuçlar açısından artmış riske sahiptir. Maternal serum SA düzeyleri hastalığın siddeti ve olumsuz perinatal sonuçlarla ilişkilidir. Bununla birlikte, UDKA tedavisine verilen klinik cevap, fetal ve neonatal sonuçları öngörmede etkili olabilir.
Predicting Factors of Uterine Invasion in Early-Stage (FIGO 2014 Stage IB1–IIA2) Cervical Cancer
Authors: TOKALIOGLU Abdurrahman Alp , ÇELİK Fatih , ERSAK Burak , AYTEKİN Okan , SELCUK İlker , ÖZGÜRLÜK İzzet , MORALOĞLU TEKİN Özlem , ÖZDAL Bülent 
Published: June 2023

Objective: Uterine corpus involvement was demonstrated radiologically or diagnosed by endometrial biopsy in the previous reports. Thus, there are few studies that detect uterine corpus involvement in radical hysterectomy specimens. This study was designed to investigate the factors that influence uterine corpus involvement in surgically treated cervical cancer patients.
Materials and Methods: A total of 269 patients with clinical early-stage (stageIB1-IIA2) cervical cancer who underwent radical hysterectomy and pelvic-paraaortic lymphadenectomy at Zekai Tahir Burak Women's Health Training and Research Hospital and Ankara Bilkent City Hospital between January 2008 and August 2021 were recruited, and their clinicopathologic data were extracted from their patient files or the hospital's electronic database.
Results: Uterine invasion was positive in 102 (37.9%) patients. Tumor size of patients was ≤20 mm in 66 (24.5%) patients and >40 mm in 82 (30.5%). Parametrial invasion was detected in 44 (16.4%) patients. In the multivariate analysis; tumor type (adenocancer vs. other tumor types) (HR: 8.94; 95% CI: 3.569–22.401; p35 mm vs. ≤35 mm) (HR: 2.34; 95% CI: 1.234–4.440; p=0.009) depth of stromal invasion (>1/2 vs. ≤1/2) (HR: 6.63; 95% CI: 2.205–19.952; p
Description of Nilgirius pygoprominulus sp. n. (Opiliones, Assamiidae, Trionyxellinae) from China, with notes on its sexual dimorphism
Authors: Zhao Jingjing , Cheng Zien , Zhang Chao 
Published: June 2023

A new species of Nilgirius, N. pygoprominulus sp. n. (male and female) in the family Assamiidae from Yunnan Province, China, is described and illustrated herein. Sexual size dimorphism (male larger than female) is inconsistent with most assamiids. Other sexually dimorphic features (body shape, leg IV and pseudonychium) are reported.
Nilgirius pygoprominulus sp. n. is described as a new species of Trionyxellinae. Information about sexual dimorphism of the species is reported.
Défaites et victoires de la relation de l’être humain avec la Nature à la lumière de C. G. Jung
Authors: Liard Véronique 
Published: June 2023

La nature est omniprésente dans l’œuvre de Jung. La première partie de l’article donne un aperçu du lien que l’homme Jung a entretenu toute sa vie avec tous les domaines du vivant. Puis l’interrogation porte sur le lien entre Nature et Civilisation. Avec l’évolution de la science et l’industrialisation, l’homme civilisé s’est-il éloigné de la Nature, dont les premiers hommes étaient encore proches, au point de préférer son confort à la protection de l’environnement ? Peut-on alors simplement parler d’une victoire de l’être humain sur la Nature ? Dans la mesure où, pour Jung, notre psyché est une partie de la Nature, peut-on affirmer que l’être humain est maître de sa propre nature ? La méconnaissance persistante qu’il a de lui-même ne fait-elle pas écho à l’ignorance des méfaits infligés depuis si longtemps à la Nature ?
Use of Female External Urinary Catheters in a Burn Intensive Care Unit: Benefits and Challenges
Authors: Won Paul , Craig Jasmine , Nevarez Claudia , Gillenwater T. Justin , Yenikomshian Haig A. 
Published: June 2023

Background
Burn patients have a relatively high rate of indwelling Foley catheter use because of their need for complex fluid management and wound care. However, Foley catheter use is associated with risks, including urinary tract infection. For female patients, an external urinary catheter is an alternative.

Objectives
To evaluate the use of female external urinary catheters in a burn intensive care unit and to develop a standard protocol.

Methods
This study involved female patients admitted to a burn intensive care unit from 2017 to 2020. An initiative to increase the use of female external urinary catheters was begun in 2019. A retrospective review of medical records was used to determine rates of indwelling and external catheter use and of catheter-associated urinary tract infection before and after implementation of the initiative.

Results
Of 77 female burn patients admitted to the unit between 2019 and 2020, 56 (73%) required indwelling Foley catheterization, a significant decrease from 94% before the initiative (P = .002). The mean duration of indwelling Foley catheter use decreased significantly from 19.4 days to 10.47 days (P = .049). Female external urinary catheters were used in 21 patients (27%). No patients with female external urinary catheters contracted urinary tract infections, compared with 9 patients with indwelling Foley catheters.

Conclusion
The use of female external urinary catheters may help reduce the risk of urinary tract infection in female burn patients. Further research is needed to refine the protocol for use of these devices and determine their safety profile.
Motivation Behind Managing Employee Information in the Banking Sector: Comparative Study Between Sri Lanka and New Zealand
Authors: Perera A. 
Published: June 2023

The purpose of this study is to investigate motivations behind managing employee information in banking sector in Sri Lanka and New Zealand. Specially, this study answers for two research questions first, why does the banking sector in Sri Lanka manage employee information and second, how does the motivations to manage employee information in banking sector in Sri Lanka different to New Zealand. Qualitative method was employed in this study and data was collected through in-depth interviews. Responses were analysed using content analysis. The findings revealed that both banking sectors in Sri Lanka and New Zealand manage employee information to achieve two purposes; internal management and external reporting. Although the study identified various differences, some of the reasons for managing employee information in both Sri Lanka and New Zealand appear similar.
COVID-19 vaccination hesitancy in South Africa: Biblical discourse
Authors: Netshapapame Tshifhiwa S. 
Published: June 2023

Churches have always been regarded as a safe haven during calamities. This changed during COVID-19 lockdown when churches were forced to shut down. The COVID-19 pandemic has posed a new normal to the world at large, calling for immediate action from authorities and introducing vaccination as an antidote. However, some religious practitioners as a vehicle of change through the institution of the church have been acting on the contrary because it discourages the uptake of vaccines, leading to vaccine hesitancy. COVID-19 vaccine hesitancy has been observed in the Christian community because Christians use Bible verses as a scapegoat for not getting a jab. There is a chasm that exists between faith and science, and it perpetuates the discourse of vaccine hesitancy.Contributions: This article applies a qualitative descriptive phenomenological approach and seeks to address the conspiracy theories and the use of Bible verses as discourse on vaccine uptake.
Chemoprevention curcumin analog 1.1 promotes metaphase arrest and enhances intracellular reactive oxygen species levels on TNBC MDA-MB-231 and HER2-positive HCC1954 cells
Authors: Novitasari Dhania , Jenie Riris Istighfari , Kato Jun-ya , Meiyanto Edy 
Published: June 2023

Background and purpose:
Previous studies highlighted that chemoprevention curcumin analog-1.1 (CCA-1.1) demonstrated an antitumor effect on breast, leukemia, and colorectal cancer cells. By utilizing immortalized MDA-MB-231 and HCC1954 cells, we evaluated the anticancer properties of CCA-1.1 and its mediated activity to promote cellular death.

Experimental approach:
Cytotoxicity and anti-proliferation were assayed using trypan blue exclusion. The cell cycle profile after CCA-1.1 treatment was established through flow cytometry. May-Grünwald-Giemsa and Hoechst staining were performed to determine the cell cycle arrest upon CCA-1.1 treatment. The involvement of CCA-1.1 in mitotic kinases (aurora A, p-aurora A, p-PLK1, and p-cyclin B1) expression was investigated by immunoblotting. CCA-1.1-treated cells were stained with the X-gal solution to examine the effect on senescence. ROS level and mitochondrial respiration were assessed by DCFDA assay and mitochondrial oxygen consumption rate, respectively.

Findings/Results:
CCA-1.1 exerted cytotoxic activity and inhibited cell proliferation with an irreversible effect, and the flow cytometry analysis demonstrated that CCA-1.1 significantly halted during the G2/M phase, and further assessment revealed that CCA-1.1 caused metaphase arrest. Immunoblot assays confirmed CCA-1.1 suppressed aurora A kinase in MDA-MB-231 cells. The ROS level was elevated after treatment with CCA-1.1, which might promote cellular senescence and suppress basal mitochondrial respiration in MDA-MB-231 cells.

Conclusion and implications:
Our data suggested the in vitro proof-of-concept that supports the involvement in cell cycle regulation and ROS generation as contributors to the effectiveness of CCA-1.1 in suppressing breast cancer cell growth.
Integrative bioinformatics analysis of ACS enzymes as candidate prognostic and diagnostic biomarkers in colon adenocarcinoma
Authors: Parsazad Ehsan , Esrafili Farina , Yazdani Behnaz , Ghafarzadeh Saghi , Razmavar Namdar , Sirous Hajar 
Published: June 2023

Background and purpose:
Acyl-CoA synthetase (ACS) enzymes play an important role in the activation of fatty acids. While many studies have found correlations between the expression levels of ACS enzymes with the progression, growth, and survival of cancer cells, their role and expression patterns in colon adenocarcinoma are still greatly unknown and demand further investigation.

Experimental approach:
The expression data of colon adenocarcinoma samples were downloaded from the Cancer Genome Atlas (TCGA) database. Normalization and differential expression analysis were performed to identify differentially expressed genes (DEGs). Gene set enrichment analysis was applied to identify top enriched genes from ACS enzymes in cancer samples. Gene ontology and protein-protein interaction analyses were performed for the prediction of molecular functions and interactions. Survival analysis and receiver operating characteristic test (ROC) were performed to find potential prognostic and diagnostic biomarkers.

Findings/Results:
ACSL6 and ACSM5 genes demonstrated more significant differential expression and LogFC value compared to other ACS enzymes and also achieved the highest enrichment scores. Gene ontology analysis predicted the involvement of top DEGs in fatty acids metabolism, while protein-protein interaction network analysis presented strong interactions between ACSLs, ACSSs, ACSMs, and ACSBG enzymes with each other. Survival analysis suggested ACSM3 and ACSM5 as potential prognostic biomarkers, while the ROC test predicted stronger diagnostic potential for ACSM5, ACSS2, and ACSF2 genes.

Conclusion and implications:
Our findings revealed the expression patterns, prognostic, and diagnostic biomarker potential of ACS enzymes in colon adenocarcinoma. ACSM3, ACSM5, ACSS2, and ACSF2 genes are suggested as possible prognostic and diagnostic biomarkers.
The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine-induced conditioned place preference in male rat
Authors: Jokar Zahra , Khatamsaz Saeed , Alaei Hojjatallah , Shariati Mehrdad 
Published: June 2023

Background and purpose:
The central nucleus of the amygdala (CeA) is one of the nuclei involved in the reward system. The aim of the current study was to investigate the electrical stimulation (e-stim) effect of the CeA in combination with dopamine D1 receptor antagonist on morphine-induced conditioned place preference (CPP) in male rats.

Experimental approach:
A 5-day procedure of CPP was used in this study. Morphine was administered at an effective dose of 5 mg/kg, and SCH23390 as a selective D1 receptor antagonist was administrated into the CeA. In addition, the CeA was stimulated with an intensity of the current of 150 μA. Finally, the dependence on morphine was evaluated in all experimental groups.

Findings /Results:
Morphine significantly increased CPP. While the blockade of the D1 receptor of the CeA reduced the acquisition phase of morphine-induced CPP. Moreover, the combination of D1 receptor antagonist and e-stim suppressed morphine-induced CPP, even it induced an aversion.

Conclusion and implication:
The current study suggests that the administration of dopamine D1 receptor antagonist into the CeA in combination with e-stim could play a prominent role in morphine dependence.
Comparative evaluation of antibacterial efficacy of active oxygen containing versus other dentifrices against Streptococcus mutans count in children with early childhood caries: A clinico-microbiological study
Authors: Jindal Tanvi , Srivastava Nikhil , Rana Vivek , Kaushik Noopur , Sharma Preeti , Pruthi Tushar 
Published: June 2023

ABSTRACT

Background:
Fluoridated dentifrices have been used for the prevention of dental caries since ages. However, to avoid the risk of fluorosis, the use of newer nonfluoridated options in dentifrices has shown a great interest in reducing Streptococcus mutans (SM) in early childhood caries (ECC).

Aim:
The study aimed to evaluate the antimicrobial efficacy of active oxygen (AO)-based dentifrice with amine fluoride (AF)-, sodium monofluorophosphate (SMP)-, herbal (HB)-, and tricalcium phosphate (TCP)-based dentifrices on SM count in children with ECC.

Materials and Methods:
Two hundred and fifty children aged 3–6 years with def ≥4 were selected and randomly divided into five groups of 50 each, based on the type of dentifrices used; Group I: AO-based, Group II: TCP, Group III: SMP, Group IV: AF, and Group V: HB dentifrice, and were asked to brush twice daily for 15 days. The saliva samples were collected at baseline, and after 15 days, cultured for SM colonies count.

Results:
Difference in colony-forming units (CFU)/ml between baseline and 15 days was highly significant in all the five groups (P < 0.001). Significant difference was observed in SM count after 15 days between Groups I and IV (P = 0.017), while nonsignificant differences were seen when compared with Groups II, III, and V (P = 0.975, 0.137, and 0.992).

Conclusions:
All the dentifrices were efficacious in reducing SM count in children with ECC. Although AO dentifrice showed superior results when compared to SMP, TCP, and HB, it did not prove to be superior to AF.