bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of red blood cell distribution width, neutrophil‐to‐lymphocyte ratio, and other hematologic parameters in canine acute pancreatitis
Authors: Johnson Meghan M. , Gicking John C. , Keys Deborah A. 
Published: August 2023

AbstractObjectiveTo determine if RBC distribution width (RDW), neutrophil‐to‐lymphocyte ratio (NLR), and other hematological parameters are associated with increased odds of in‐hospital mortality, increased length of hospitalization (LOH), or disease severity as measured by the Canine Acute Pancreatitis Severity (CAPS) score in dogs with acute pancreatitis (AP).DesignRetrospective, multicenter study from January 2016 to August 2020.SettingFour private emergency and specialty referral centers.AnimalsOn initial case search, 118 client‐owned dogs were identified with a clinical diagnosis of AP. Out of these cases, 114 dogs met inclusion criteria, defined as sudden onset of ≥2 compatible clinic signs (lethargy, anorexia, vomiting, or abdominal pain), a specific canine pancreatic lipase concentration >400 μg/L, hospital admission, as well as CBC and serum biochemistry run within 48 hours of initial hospitalization. Disease severity was calculated and measured using the CAPS score, in addition to LOH and in‐hospital mortality.InterventionsNone.Measurements and Main ResultsClinical endpoints were in‐hospital mortality, LOH, and disease severity, as evaluated by the CAPS score. Overall in‐hospital mortality was 36.8%. NLR was significantly associated with survival, with a higher percentage being associated with an increased likelihood of nonsurvival (odds ratio: 1.1, 95% confidence interval: 1.0–1.2;P = 0.006, adjustedP = 0.04). Increased NLR was found to be significantly associated with a longer LOH based on the unadjustedP‐value (P = 0.02) but was not statistically significant based on aP‐value adjusted for multiple comparisons (P = 0.12). No significant associations were noted when RDW, platelet‐to‐lymphocyte ratio, WBC count, mean platelet volume, RDW‐to‐platelet ratio, or RDW‐to‐total serum calcium ratio was evaluated against outcome measures.ConclusionsThis study retrospectively evaluated the prognostic utility of several readily available hematological parameters in dogs hospitalized for AP. Dogs with an increased NLR may have a higher risk of in‐hospital mortality and increased LOH, although future prospective studies are necessary to confirm these findings.
Assessment of a standing position during abdominal point‐of‐care ultrasound on abdominal fluid score in dogs
Authors: Buckley Christy , Seitz Marc , Wills Robert W. , Lee Alison M. 
Published: August 2023

AbstractObjectiveTo assess the use of a standing position during abdominal point‐of‐care ultrasound (POCUS) examination when evaluating dogs for peritoneal effusion.DesignRandomized prospective study over 17 months.SettingSingle‐center, university veterinary teaching hospital.AnimalsThirty dogs presenting for acute abdominal disease. Eligibility included suspicion for free peritoneal effusion and the ability to stand.InterventionsDogs underwent standing abdominal POCUS, right lateral abdominal POCUS, and a full abdominal ultrasound. We originally had nothing listed. It now includes all three ultrasound evaluations that were performed for each patient.Measurements and Main ResultsPatients underwent both a right lateral and standing abdominal POCUS via a previously described abdominal focused assessment with sonography for trauma (A‐FASTrl and A‐FASTs, respectively) technique in a randomized and sequential order followed by a full abdominal ultrasound (AUS‐full). The A‐FASTs examination included a right flank location in addition to the following standard views: subxiphoid, left flank, urinary bladder, and umbilicus. Five‐second cine loops were obtained at each location for each examination and reviewed in the order they were obtained. Locations for both A‐FAST exams were interrogated in the same order every time. The cine loops were scored for the degree of peritoneal effusion based on a previously published abdominal fluid scoring system by a board‐certified radiologist, radiology resident, and radiology intern. The overall abdominal fluid score (AFS) was compared to a subjective full abdominal ultrasound score given by a board‐certified radiologist. Six dogs had no peritoneal effusion, 13 had a small volume (AFS 1 or 2), and 11 had a moderate to large volume (AFS 3 or 4). Excellent agreement (intraclass correlation coefficient) was found between the A‐FASTs and A‐FASTrl techniques (0.95, 0.93, 0.94), good agreement between A‐FASTs and AUS‐full (0.80, 0.77, 0.82), and good agreement between A‐FASTrl and AUS‐full (0.80, 0.82, 0.84). The interobserver agreement was good (0.87) for the A‐FASTs technique and excellent (0.91) for the A‐FASTrl technique. Mean observer agreement score was excellent (0.94) when evaluating A‐FASTrl to A‐FASTs, good (0.86) when evaluating A‐FASTs to AUS‐full, and good (0.87) when evaluating A‐FASTrl to AUS‐full.ConclusionPerforming a standing abdominal POCUS examination may be a valid option for identifying and quantifying peritoneal effusion in situations when a more traditional right lateral approach cannot be performed.
Families of ϕ‐congruence subgroups of the modular group
Authors: Babei Angelica , Fiori Andrew , Franc Cameron 
Published: August 2023

AbstractWe introduce and study families of finite index subgroups of the modular group that generalize the congruence subgroups. Such groups, termed ϕ‐congruence subgroups, are obtained by reducing homomorphisms ϕ from the modular group into a linear algebraic group modulo integers. In particular, we examine two families of examples, arising on the one hand from a map into a quasi‐unipotent group, and on the other hand from maps into symplectic groups of degree four. In the quasi‐unipotent case, we also provide a detailed discussion of the corresponding modular forms, using the fact that the tower of curves in this case contains the tower of isogenies over the elliptic curve defined by the commutator subgroup of the modular group.
Copaiba oil improves pulmonary nitric oxide bioavailability in monocrotaline-treated rats
Authors: Campos-Carraro Cristina , Turck Patrick , de Lima-Seolin Bruna Gazzi , Teixeira Rayane Brinck , Zimmer Alexsandra , Araujo Alex Sander da Rosa , Belló-Klein Adriane 
Published: August 2023

Oxidative stress is involved in increased pulmonary vascular resistance (PVR) and right ventricular (RV) hypertrophy, characteristics of pulmonary arterial hypertension (PAH). Copaiba oil, an antioxidant compound, could attenuate PAH damage. This study’s aim was to determine the effects of copaiba oil on lung oxidative stress, PVR, and mean pulmonary arterial pressure (mPAP) in the monocrotaline (MCT) model of PAH. Male Wistar rats (170 g, n = 7/group) were divided into four groups: control, MCT, copaiba oil, and MCT + copaiba oil (MCT-O). PAH was induced by MCT (60 mg/kg i.p.) and, after 1 week, the treatment with copaiba oil (400 mg/kg/day gavage) was started for 14 days. Echocardiographic and hemodynamic measurements were performed. RV was collected for morphometric evaluations and lungs and the pulmonary artery were used for biochemical analysis. Copaiba oil significantly reduced RV hypertrophy, PVR, mPAP, and antioxidant enzyme activities in the MCT-O group. Moreover, increased nitric oxide synthase and decreased NADPH oxidase activities were observed in the MCT-O group. In conclusion, copaiba oil was able to improve the balance between nitric oxide and reactive oxygen species in lungs and the pulmonary artery and to reduce PVR, which could explain a decrease in RV hypertrophy in this PAH model.
Analytical solutions of spherical structures with relativistic corrections
Authors: Bhatti M. Z. , Ijaz S. , Almutairi Bander , Khan A. S. 
Published: August 2023

AbstractThis paper analyzes the characteristic of a non-static sphere along with anisotropic fluid distribution in the background of modified $$f(\mathcal {G})$$

f
(
G
)

theory. Conformal Killing vector is a productive constraint for computing reliable results for modified field equations. The occurrence of conformal Killing vector indicates the existence of symmetries in spacetime and it permits us to choose the coordinates that reduce the number of independent variables. Subsequently, for different conformal Killing vector choices, we obtain several types of precise analytical solutions for both non-dissipative and dissipative systems. We compute the matching conditions in the context of $$f(\mathcal {G})$$

f
(
G
)

gravity. In addition to this, we apply specific constraints to the matching conditions in an attempt to determine the significant results. Further, we proceed our investigation by utilizing quasi-homologous condition and vanishing complexity factor condition. Finally, we summarize all the important results which may help to understand the properties of astrophysical objects.
Dust emissions and OH masers: evidence for tracing advanced stages of HMPOs
Authors: Edris Khaled A. , Darwish Mohamed S. 
Published: August 2023

AbstractWe conducted a study using the Green Bank Telescope to investigate the correlation between OH masers and mm emission in high mass star forming regions (HMSFRs) using archival data from the Bolocam Galactic Plane Survey (BGPS) at 1.1 mm. Our objective was to gain insights into the physical characteristics, dynamics, and evolutionary status of these regions. Among the 27 OH maser sources examined, we found that 23 of them exhibited associations with multiple peaks of millimeter emission within a 30$$'$$

′

radius. Notably, two high mass protostellar object candidates, namely IRAS 18089-1732 and IRAS 19035 + 0641, displayed consistent tracers. Interferometer observations further supported our findings. Compared to methanol masers, OH masers exhibited a lower level of consistency with mm sources, with a coincidence rate of 11$$\%$$
%
at offsets of 0.5 arcsec or less. At 3$$''$$

′
′

offset, 13 (48$$\%$$
%
) OH maser sources were found to be associated with mm continuum emission, with 11 previously classified as evolved HMSFRs. However, at larger offsets of 20$$''$$

′
′

, the association rate increased significantly to 63$$\%$$
%
, indicating a broader spatial distribution of OH masers. This variation in offsets could be attributed to the presence of OH masers from different layers of the circumstellar disk. Our results suggest that the association between OH masers and mm emission may serve as a tracer for advanced stages of high mass protostellar objects. Future high angular resolution observations are recommended to enhance our understanding of this association.
Safety and Tolerability of Low-Dose Radiation and Stereotactic Body Radiotherapy + Sintilimab for Treatment-Naïve Stage IV PD-L1+ Non–Small Cell Lung Cancer Patients
Authors: Zhou Xiaojuan , Zhou Laiyan , Yao Zhuoran , Huang Meijuan , Gong Youling , Zou Bingwen , Zhu Jiang , Liu Yongmei , Peng Feng , Zhang Yan , Yu Min , Li Yanying , Na Feifei , Wu Yijun , Kang Kai , Xiu Weigang , Zhang Xuanwei , Zhou Lin , Xu Yong , Wang Jin , Wang Yan , Yang Xue , Wu Yuanjun , Li Rui , Zhang Yu , Yang Zhenzhou , Zhou Zhipeng , Bai Jing , Yi Xin , Tong Ruizhan , Yin Limei , Chen Chong , Niedermann Gabriele , Lu You , Xue Jianxin 
Published: August 2023

Abstract

Purpose:
Low-dose radiotherapy (LDRT) may enhance the synergistic antitumor effect of combined immunotherapy and stereotactic body radiotherapy (SBRT). The safety and efficacy of this novel triple-combination therapy were evaluated for the first time as first-line treatment for patients with metastatic non–small cell lung cancer (NSCLC).

Patients and Methods:
This prospective phase I study enrolled 29 patients and included a dose-escalation and dose-expansion phase. Patients received SBRT [30 Gray (Gy)/3f] to small lesions and LDRT (2 Gy/1f, 4 Gy/2f, or 10 Gy/5f) to a large lesion concurrently, followed by sintilimab (a programmed death-1 inhibitor). The primary endpoint was safety and tolerability; secondary endpoints included objective response rate (ORR), progression-free survival (PFS), and overall survival (OS).

Results:
No dose-limiting toxicities were observed during the dose-escalation phase; 4 Gy/2f was the recommended LDRT dose. Median follow-up was 15.6 months. Treatment-related adverse events (TRAE) occurred in 96.6% (28/29) of patients [grade ≥ 3; 20.7% (6/29)]; 2 patients (6.9%) discontinued due to TRAEs. Seven patients experienced pneumonitis (grade 2, n = 6; grade 3, n = 1). Immune-related adverse events were noted in 58.6% (17/29) of patients. In patients with tumor assessment (n = 28), ORR and confirmed ORR were 60.7% and 57.1%, respectively. Median PFS was 8.6 months (95% confidence interval, 3.7–16.5), and median OS was not reached. Exploratory analyses suggested both expanded and newly emerging T-cell receptor clonotypes were associated with better PFS.

Conclusions:
The findings indicate that the novel SBRT + LDRT + sintilimab therapy is safe and promising in patients with programmed death ligand-1–positive, driver gene–negative primary metastatic NSCLC.
Abstract A019: Development and characterization of novel pre-clinical models of SFPQ-TFE3-driven renal cell carcinoma
Authors: de Aragao Mendes Adrianna Amaral , Liu Hans , Woo Juhyung , Asrani Kaushal , Rosenberg Avi , Argani Pedram , Lotan Tamara 
Published: August 2023

Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR001) of the Conference Program/Proceedings.
Citation Format: Adrianna Amaral de Aragao Mendes, Hans Liu, Juhyung Woo, Kaushal Asrani, Avi Rosenberg, Pedram Argani, Tamara Lotan. Development and characterization of novel pre-clinical models of SFPQ-TFE3-driven renal cell carcinoma [abstract]. In: Proceedings of the AACR Special Conference: Advances in Kidney Cancer Research; 2023 Jun 24-27; Austin, Texas. Philadelphia (PA): AACR; Cancer Res 2023;83(16 Suppl):Abstract nr A019.
Abstract B004: Serine promotes invasive phenotype through enhanced translation of SNAIL in ccRCC
Authors: Karki Suman 
Published: August 2023

Abstract
Background: Metastatic clear cell renal cell carcinoma (ccRCC) is the most common type of renal carcinoma with a median survival rate of about 13 months and is refractory to chemotherapy. ccRCC is fundamentally a metabolic disease characterized by extensive reprogramming in amino acid metabolism. Serine is a nonessential amino acid (NEAA), and the serine biosynthetic pathway has been shown as an essential source of metabolic intermediates in many cancers. Analysis of the TCGA database reveals that ccRCC tumors have reduced levels of PHGDH, the first enzyme in the de novo serine biosynthesis pathway, and makes serine conditionally essential amino acid in these tumors. The role of serine in tumorigenesis is well established; however, its role in promoting invasive phenotype and metastasis is not explored. Methods: To gain insight into the role of nonessential amino acids in proinvaisive phenotypes, we performed wound healing and migration assays in the presence of individual NEAAs. The importance of serine synthesis for promoting invasive phenotype was also assessed by restoring PHGDH in low PHGDH ccRCC. Results: In an unbiased approach, we found that serine is required for the increased migratory and invasive phenotype in ccRCC. We also demonstrate that in low PHGDH ccRCC cells, exogenous serine is to maintain SNAIL expression and the enhanced migratory and invasive phenotype. We also show that serine depletion induces translational inhibition in low PHGDH ccRCC. Conclusion: The role of serine in tumorigenesis and cell proliferation is well established; however, its role in supporting invasive and metastatic phenotypes is previously unknown. Our data highlights a novel role for serine in promoting EMT through enhanced translational maintenance of SNAIL, which may be therapeutically targeted in ccRCC.
Citation Format: Suman Karki. Serine promotes invasive phenotype through enhanced translation of SNAIL in ccRCC [abstract]. In: Proceedings of the AACR Special Conference: Advances in Kidney Cancer Research; 2023 Jun 24-27; Austin, Texas. Philadelphia (PA): AACR; Cancer Res 2023;83(16 Suppl):Abstract nr B004.
Abstract B023: Using hypoxia to improve tumor infiltrating lymphocytes therapy in different subtypes of renal cell carcinoma
Authors: Potez Marine , Alkhouli Mohammed , Ali Johannes , Carter Michael , Beatty Matthew , Pilon-Thomas Shari , Chahoud Jad 
Published: August 2023

Abstract
BACKGROUND: Improving the long-term efficacy for advanced renal cell carcinoma (RCC) remains challenging after progression on first line therapy. Adoptive cell therapy (ACT) using tumor infiltrating lymphocytes (TIL) is a promising personalized immunotherapeutic approach to treating solid tumors. Previously, TIL therapy for clear cell RCC patients showed moderate success but did not account for the distinct immune microenvironments in different subtypes of RCC such as clear cell (ccRCC), papillary (pRCC) or unclassified (uRCC) known to have different response to immunotherapy. In addition, hypoxia plays a critical role in tumor progression and therapy resistance in RCC. Therefore, the aim of this study was to evaluate TIL expansion from different subtypes of RCC under varying oxygen concentrations. METHODS: Tumor types collected from 48 patients included ccRCC (81.25%), pRCC (16.7%) and uRCC (8.3%). Tumors were minced into fragments and cultured for 4 weeks in media supplemented with high dose IL-2 (6000 IU/mL). At the end of the 4 weeks, TIL were further expanded using a rapid expansion protocol (REP) in either 20% or 5% oxygen. TIL expansion, reactivity to autologous tumor, and phenotype were evaluated in pre-REP and post-REP samples. RESULTS: Among the ccRCC, 91.7% of the samples expanded, while 100% of the pRCC and uRCC expanded. pRCC expanded more TIL than ccRCC (1.05e8 vs 6.7e7 total TIL expanded, respectively) while uRCC expanded less than the other subtypes (2.03e7). Pre-REP reactivity against autologous tumors was high for all the subtypes (88.3%, 75% and 100% for ccRCC, pRCC and uRCC respectively). The T-cell phenotype across subtypes showed a tendency of more CD4+ T-cells and less CD8+ T-cells for pRCC and uRCC, compared to ccRCC. All subtypes that underwent REP were able to expand in both 20% and 5% O2 (hypoxia) conditions. TIL expanded in hypoxia had a significantly higher percentage of tissue resident memory T-cells (CD69+CD103+; 15.1%, p&lt;0.0001) when compared to the pre-REP TIL population (2%) or TIL expanded at 20% O2 (3.1%). CONCLUSION: These results demonstrate the feasibility of expanding tumor-reactive TIL from different subtypes of RCC for the first time, and highlight the advantage of exposing TIL to hypoxic conditions to enhance the differentiation of resident memory T-cells in TIL products.
Citation Format: Marine Potez, Mohammed Alkhouli, Johannes Ali, Michael Carter, Matthew Beatty, Shari Pilon-Thomas, Jad Chahoud. Using hypoxia to improve tumor infiltrating lymphocytes therapy in different subtypes of renal cell carcinoma [abstract]. In: Proceedings of the AACR Special Conference: Advances in Kidney Cancer Research; 2023 Jun 24-27; Austin, Texas. Philadelphia (PA): AACR; Cancer Res 2023;83(16 Suppl):Abstract nr B023.
STICH3C: Rationale and Study Protocol
Authors: Fremes Stephen E. , Marquis-Gravel Guillaume , Gaudino Mario F.L. , Jolicoeur E. Marc , Bédard Sylvain , Masterson Creber Ruth , Ruel Marc , Vervoort Dominique , Wijeysundera Harindra C. , Farkouh Michael E. , Rouleau Jean-Lucien , Karkhanis Reena , Arora Rakesh , Graham Michelle , Healey Jeff , Howlett Jonathan , Kiss Alex , Ko Dennis , Lee Doug , McGillion Michael , Sun Louise , Swartz Richard , Voisine Pierre , Bax Jeroen , Crea Filippo , Doenst Torsten , Jolly Sanjit , Koeber Lars V. , Lamy Andre , Lansky Alexandra , van der Meer Peter , Milojevic Milan , Omerovic Elmir , Petrie Mark , Reid Christopher , Sandner Sigrid , Sousa-Uva Miguel , Velazquez Eric , Verma Subodh , Stone Gregg W. , Spertus. John 
Published: August 2023

BACKGROUND:
Coronary artery bypass grafting (CABG) is the recommended mode of revascularization in patients with ischemic left ventricular dysfunction (iLVSD) and multivessel disease. However, contemporary percutaneous coronary intervention (PCI) outcomes have improved with the integration of novel technologies and refinement of revascularization strategies, and PCI is often used in clinical practice in this population. There is a lack of evidence from randomized trials comparing contemporary state-of-the-art PCI versus CABG for the treatment of iLVSD and multivessel disease. This was the impetus for the STICH3C trial (Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy), described here.

METHODS:
The STICH3C trial is a prospective, unblinded, international, multicenter trial with an expected sample size of 754 participants from ≈45 centers. Patients with multivessel/left main coronary artery disease and iLVSD with left ventricular ejection fraction ≤40% considered by the local Heart Team appropriate for and amenable to revascularization by both modes of revascularization will be randomized in a 1:1 ratio to state-of-the-art PCI or CABG.

RESULTS:
The primary end point is the composite of death from any cause, stroke, spontaneous myocardial infarction, urgent repeat revascularization, or heart failure readmission, summarized as a time-to-event outcome. The key hierarchical end point is time to death and frequency of hospitalizations for heart failure. The key safety outcome is a composite of major adverse events. Disease-specific quality-of-life and health economics measures will be compared between groups. Participants will be followed for a median of 5 years, with a minimum follow-up of 4 years.

CONCLUSIONS:
STICH3C will directly inform patients, clinicians, and international practice guidelines about the efficacy and safety of CABG versus PCI in patients with iLVSD. The results will provide novel and broad evidence, including clinical events, health status, and economic assessments, to guide care for patients with iLVSD and severe coronary artery disease.

REGISTRATION:

URL:
https://clinicaltrials.gov/
; Unique identifier: NCT05427370.
Seeing the Biblical World of Sodom-Mamre Through Surveillance
Authors: Alsen Carolyn 
Published: August 2023

Abstract
Genesis depicts a world of tension and collaboration among the groups and families that constitute the stories of the formation of early Israel. The obedience and behaviour of characters within the narrative determine covenantal inclusion or exclusion. The narrative of Sodom-Mamre can be interpreted as a story of surveillance, wherein characters observe each other and act based on their desire for knowledge and control. Though surveillance promises omniscience, knowledge ultimately remains limited. The divine character yearns to witness human experience, while the human characters act as mirrors to this impulse. Lot’s wife highlights the chasm between the desire to see and know and the limits of a gaze. Ultimately, this desire begets violence as the surveillant gaze produces cognitive dissonance and narcissism. This essay references surveillance studies, critical biblical scholarship, psychoanalytic and philosophical traditions concerning desire, particularly the desire of the eyes, the gaze, and ancient imperial surveillance practices.