bluuebunny/crossref_metadata_2025_split huggingface dataset:
PS-C07-3: PREVALENCE AND DEMOGRAPHIC PROFILE OF WHITE-COAT HYPERTENSION IN THE PATIENTS PRESENTING A TERTIARY CARE CENTER IN EASTERN NEPAL
Authors: Karki Prahlad , Ghimire Jeet P , Karki Biplave , Pandey Naveen K , Shah Prashant 
Published: January 2023

Background:
There is unequivocal evidence showing that at hospital environment BP levels are usually different from measures found at other settings. Therefore, ambulatory BP is expected to be more dependable, as well as allow the identification of a relevant subgroup of white-coat hypertension patient.

Methods:
This was a single center descriptive cross-sectional study conducted to assess the prevalence of white-coat hypertension among 50 participants consisting of 31 males and 19 females referred for 24 hour Ambulatory BP monitoring in B .P. Koirala Institute of Health Sciences, Dharan, Nepal, between October 2021 to December 2021.

Results:
The prevalence of white-coat hypertension was 19 (32%) among 50 participants, while 31(62%) of them had sustained hypertension. Prevalence of WCHTN and sustained hypertension in young age equal or less then 35 years was 4 (21.1%) and 10 (32.3%) respectively, similarly middle age 36–54 years was 13(68.4%) and 16(51.6%) and elderly equal or more then 55 years was 2(10.5%) and 5(16.1%) respectively. Most participants were of middle age group 36–54 years age. While of sex distribution pattern of WCHTN and sustained hypertension, male was 11(57.9%) and 20 (64.5%) respectively and female was 8(36.8%) and 15(48.4%) respectively. The association between the demographic variables age, sex and BMI and white-coat HTN was not statistically significant.

Conclusion:
The study showed that White-coat hypertension was more common in male patients and in middle age group 36–54 years, but was not statistically significant. Prevalence of white-coat hypertension was 19(38%). There was no significant association between white-coat hypertension and demographic variables.
PS-C09-1: CORRELATION OF SYMPATHETIC NERVOUS SYSTEM ACTIVITY AND BLOOD PRESSURE IN HYPERTENSIVE PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE
Authors: Kakouri Niki , Andrikou Ioannis , Konstantinidis Dimitrios , Siafi Eirini , Manta Eleni , Polyzos Dimitrios , Drogkaris Sotirios , Tatakis Fotis , Kariori Maria , Zamanis Ioannis , Iliakis Panagiotis , Papakonstantinou Pantelis , Grigoriou Kalliopi , Thomopoulos Costas , Tsioufis Konstantinos 
Published: January 2023

Objective:
Nonalcoholic fatty liver disease (NAFLD) is associated with hypertension and predicts future cardiovascular events. The purpose of this study was to investigate the effect of sympathetic nervous system (SNS) overactivity on blood pressure levels in hypertensive patients with and without NAFLD.

Design and method:
111 newly diagnosed untreated hypertensive patients (mean age 55 ± 10 years, 48 males, mean office systolic/diastolic BP 140 ± 14.8/88 ± 9.9 mmHg) without history of cardiovascular disease underwent office blood pressure (BP) measurements. NAFLD was diagnosed by liver ultrasound to separate patients into those with and without NAFLD. SNS activity was assessed by muscle sympathetic nerve activity (MSNA) based on established methodology (microneurography).

Results:
Hypertensive patients with NAFLD (n = 71) compared to those without NAFLD (n = 40) were younger (53 ± 10 vs 58 ± 9 years, respectively, p = 0.01) with greater body mass index (33 ± 10 vs 26 ± 3 kg/m2, p < 0.001). Also, male gender was more prevalent in the NAFLD group compared to the non-NAFLD group (52% vs 29%, respectively, p = 0.03), whereas there were no differences in glucose, low density lipoprotein levels and glomerular filtration rate. In NAFLD patients, MSNA was correlated with office diastolic BP (r = 0.24, p = 0.02) and in linear multiple regression analysis MSNA levels were an independent determinant of office diastolic BP levels (beta = 0.185, p = 0.05), while in the non NAFLD group, MSNA was not related to office BP levels (p = ns). MSNA levels were greater in hypertensives with NALFD compared to those without NAFLD (44.3 ± 9.5 vs 40 ± 7.5 bursts per minute, respectively, p < 0.04). Moreover, in multiple logistic regression analysis, MSNA was proven as an independent determinant of the presence of NAFLD (OR 1.2, 95% CI 1.01–1.5), p = 0.04).

Conclusions:
In conclusion, higher sympathetic nervous system activity, as assessed by MSNA, is associated with greater diastolic BP in NAFLD patients compared to their non-NAFLD counterparts. These findings suggest that SNS may contribute importantly to the regulation of BP in NAFLD patients.
PS-C09-3: DETECTION OF NOCTURNAL HYPERTENSION BY SELF-MEASUREMENT OF BLOOD PRESSURE MEASUREMENT
Authors: Ozono Ryoji 
Published: January 2023

Outside-office BP measurements are recommended for the diagnosis of hypertension because of its better prediction for the cardiovascular (CV) risks compared to that of office BP. Nocturnal hypertension (NH), detectable only by outside-office measurement, is a strong CV risk predictor. However, in the real-world clinical setting, ambulatory blood pressure monitoring is not routinely conducted at least in part because of its annoyance (clinical inertia). In the present study, usefulness of home BP self-measurement, much easier to practice, upon detecting NH was sought.
Subjects were patients with hypertension being treated in Ozono Clinc, Internal Medicine and Cardiology (n = 45, mean age72.8 +/-13, M26:F19). BP was self-measured by a sphygmomanometers provided by the clinic (OMRON HEM-7080 IC), which is equipped with timer-triggered BP measuring system at preset times. Patients were asked to record their morning BP (within one hour after getting-up) and evening BP (just before going to the bed). For detection of nocturnal BP, patients were informed to sleep with the cuffs set around their arms, then the recordings were obtained at 2:00. 3:00, 4:00 and 5:00. NH was defined as having the average of the four systolic BPs (SBPs) during sleep exceed 120 mmHg.
Among the 45 patients 23 (51%) had NH. Relations between the existence of morning hypertension (SBP > 130 mmHg) or evening hypertension (SBP > 130 mmHg) and the existence of NH was shown in the table. When morning or evening hypertension exist, the prevalence of NH was around 60%. On the other hand, if morning hypertension does not exist, the rate of NH is very low. Interestingly, some patients without evening hypertension develop NH during night. Home blood pressure measurement is a convenient and useful clinical tool to estimate NH.
PS-C09-5: AUSCULTATORY AND OSCILLOMETRIC AMBULATORY BLOOD PRESSURE MONITORING: METHODS COMPARISON IN ADULT PATIENTS
Authors: Zhemanyuk Svitlana Pavlina , Syvolap Vitaliy Victorovich 
Published: January 2023

Background/Introduction:
Ambulatory blood pressure monitoring (ABPM) is an out-of-office method of blood pressure (BP) detection in usual patients activities via oscillometric or auscultatory recording devices. Correct measurement is crucial as for diagnosis, as treatment purpose. There are different rules for each method exist, however, they are not respected much for ABPM.
The aim of the study was to compare a combined (oscillometric and auscultatory) ABPM device in adult individuals.

Methods:
One-hundred twenty-two patients had 24-hour clock-based definitions (nighttime: 01:00 to 05:59) ABPM patterns (mean age, 62 [95% CI, 60–63] years, 44% men) performed with a combined (oscillometric and AUSCULTATORY) device. Analyzing reading numbers in awake and night periods (not-valid: < 20 and < 7 readings, respectively) the validity was verified. Arterial hypertension was evaluated according to diurnal ABPM.

Results:
Twenty-four-hour systolic and diastolic BP were equal using auscultatory and oscillometric monitoring (140.3 and 139.6 mmHg, 77.2 and 79.0, respectively, NS). In hypertensions, 9.5% systolic and 4.0% diastolic BP patterns were outside the limits of agreements according to Bland-Altman analysis. Meanwhile, in normotensive individuals, 6.4% both for systolic and diastolic (for the population, 7.4% systolic and 5.0% diastolic BP).

Conclusion:
Using the oscillometric and auscultatory methods for ABPM show the same level of diurnal systolic and diastolic BP, but with the hypertension misclassification along with systolic BP rises in adults.
PS-C09-8: FEATURES OF DAILY BLOOD PRESSURE PROFILE IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBESITY
Authors: Duysenbaeva Aziza , Mirakbarova Kamola , Srojidinova Nigora 
Published: January 2023

Purpose of the study:
To study the daily profile of blood pressure in patients with arterial hypertension (AH) with obesity.

Materials and methods of the study:
The study included 71 patients with AH I-III degree (ESH, 2018) who received inpatient treatment. Obesity was defined according to the WHO classification (1997). The daily blood pressure profile was assessed using the Medicom-Combi device (Russia). Blood pressure was measured at intervals: day - 30 minutes, night - 60 minutes.

Results of the study:
Patients were divided into 3 groups depending on the degree of obesity: group 1 BMI 30–34.9 kg/m2 (43 patients), group 2 BMI 35–39.9 kg/m2 (19 patients) and group 3 BMI > 40 kg/m2 (9 patients). The compared groups had similar office SBP and DBP: 144.88 ± 21.84/88.14 ± 10.75 mm Hg. vs 143.42 ± 21.86/87.89 ± 9.76 mmHg vs 145.56 ± 17.40/87.78 ± 14.81 mmHg. Analysis of ambulatory blood pressure monitoring (ABPM) revealed that 3 grade obese patients with AH had significantly higher mean daily SBP values (124.98 ± 11.16 vs 120.00 ± 7.18 vs 132.22 ± 12.85 mm Hg, p < 0.018) and DBP (73.93 ± 8.86 vs 68.21 ± 4.71 vs 74.00 ± 7.68 mm Hg, p < 0.02), mean daily SBP (127.14 ± 10 .82 vs 120.95 ± 6.88 vs 134.11 ± 11.59 mmHg, p < 0.005), mean daily DBP (75.79 ± 9.41 vs 69.42 ± 4.98 vs 77.44 ± 7 .80 mm Hg, p < 0.012) compared with AH patients with 1–2 grade obesity. Variability in SBP and DBP did not differ significantly between the groups. The load index of SBP in the daytime was high in AH patients with 3rd grade obesity. Index of SBP daytime were 37.26 ± 29.31 (group 3 patients) vs 7.04 ± 9.78 (group 2) vs 16.35 ± 19.41% (group 1) p < 0.0009. A normal daily profile of SBP/DBP had 30.23%/37.21% of patients of the 1st group vs 21.05%/42.10% of patients of the 2nd group vs 33.33%/33.33% of patients of the 3rd group had, p < 0.145. The number of non-dippers in SBP was slightly higher in the group of patients with grade 1 obesity: night reduction speed (NRS) SBP/DBP 53.48%/ 46.51% in group 1 vs 52.63%/36.84% in group 2 vs 44.44%/ 33.33% in the third, p < 0.113. In the group of patients with grade 3 obesity, persons with daily SBP/DBP ‘night-picker’ profile significantly prevailed: 22.22%/22.22% vs 21.25%/21.05% vs 16.27% /13.95%, (in groups 3, 2, 1, respectively) p < 0.001. There were no patients with an excessive decrease in SBP and DBP at night.

Conclusion:
Patients with hypertension and obesity have more pronounced pronounced disturbances in the daily blood pressure profile, which contribute to an increased risk of developing complications of arterial hypertension.
PS-C10-8: ANALYSIS OF OFFICE SYSTOLIC BLOOD PRESSURE MEASURED BY VARIOUS METHODS IN DIFFERENT CONDITIONS
Authors: Muzik Jan , Peleska Jan , Holubova Anna , Camek Rene , Navratil Vojtech , Fiala Dominik , Doksansky Marek , Hana Karel , Kaspar Jan , Vranka Jakub , Hronova Julie , Chrolenko Anna , Jiravova Maria , Dolezil David , Jozifova Marie 
Published: January 2023

Objectives:
The aim of the study is to confirm results of our pilot study (presented ESH/ISH Glasgow 2021) and perform a detailed analysis of the larger sample size.

Design and Method:
BP monitors Nissei DM-3000 (both auscultatory and oscillometric), SunTech-40 and Fora P30 Plus, in both conditions, were used for office BP measurements (BPM) in triplets by one physician at the entry and exit phase of the 3 months home BP telemonitoring study. 122 treated patients with essential hypertension, aged 24–85 years, 60% of males, were referred by their physicians as well controlled. Their therapy was not changed during this study. Those starting BPMs in the office at the entry, started BPMs in the quiet room at the exit, and vice versa, approximately at the same time. On the other hand, the order of methods used both in the office and in the quiet room was not changed. Effects of gender, age, BMI, order of BPM (physician/quiet room - P/QR, order of BPM in triplets) and methods of BPM on systolic BP at the entry and exit of the study were evaluated. Linear mixed models with random effect of a patient were used for the statistical analysis of data.

Results:
Systolic BP (SBP) values significantly depended on the morning medication (yes, no, p = 0.005) and the method of BPM used (p < 0.001). SBP values of various methods varied in dependence on the phase of the study (entry, exit, p < 0.001), age (< 60,> = 60, p < 0.001) and BMI (< 30,> = 30, p < 0.001). SBP was not dependent on the measurement order P/QR significantly. If each method of BPM was analyzed independently on other ones, only auscultatory SBP depended significantly on the measurement order in triplets (p < 0.001). Decrease of mean SBP+SD from the first to the third BPM was seen only at the entry phase of the study - 128.8 + 13.0, 126.0 + 13.5 and 124.7 + 12.6 mmHg.

Conclusions:
Significant differences between BPM methods used in systolic BP measurement were found. Fora BP monitor showed especially higher mean SBP values probably due to a stress from the first contact with a telemonitoring equipment in the quiet room only at the entry (132.0 + 12.9) vs. (127.3 + 12.3) mmHg. We did not prove any influence of measurement order P/QR even when Fora was used in both attended and unattended conditions.
If an independent analysis of BPM methods was used, only auscultatory SBP depended significantly on the measurement order in triplets, whereas no significant influence was shown in oscillometric methods.
PS-C11-4: UPPER ARM SBP DECLINE ASSOCIATED WITH REPEATED CUFF-OSCILLOMETRIC INFLATION SIGNIFICANTLY CORRELATED WITH ARTERIAL STIFFNESS INDEX
Authors: Kawaura Noriyuki , Ishigami Tomoaki , Tamura Kouichi 
Published: January 2023

Background:
It is unknown how the repeated cuff-oscillometric inflations with blood pressure measurements are related to arterial stiffness and central arterial pressure, and how changes to the novel indexes of arterial stiffness, AVI (arterial velocity pulse index) and API (arterial pressure volume index) will be brought about by the repeated cuff-oscillometric inflations.

Aim:
We evaluated the clinical significance of the new non-invasive vascular indexes AVI and API in outpatients with various clinical backgrounds to explore potential utilities of these two indexes by using repeated cuff-oscillometric inflation in actual clinical settings.

Methods:
In 250 consecutive outpatients, we performed a cross-sectional, retrospective, single center, observational study to investigate arterial stiffness using blood pressure and the AVI and API with three times repeated measurements that used multifunctional blood pressure monitoring device, AVE-1500 (Shisei Datum, Tokyo, Japan).

Results:
Of the 250 enrolled subjects, 236 were analyzed. 62.7% of the patients were male, with an overall mean age of 68.1 ± 12.1. The mean SBP (systolic blood pressure) and DBP (diastolic blood pressure) of first time measurement were 133.07 ± 21.20 mmHg and 73.94 ± 13.56 mmHg, respectively. The mean AVI and API of first time measurement were 23.83 ± 8.30 and 31.12 ± 7.86, respectively. In each measurement with repeated measurements of BP (SBP/DBP), AVI and API, although DBP and AVI did not have the significant changes throughout the measurements, both SBP and API decreased significantly according to the measurement orders.

Conclusions:
In this study, upper arm SBP decline associated with repeated cuff-oscillometric inflation significantly correlated with arterial stiffness index. Furthermore, it would suggest that arterial stiffness could be predicted by the changes in repeated SBP measurements.
PS-C13-7: THE ROLE OF WATER HAMMER PRESSURE IN THE GLOMERULAR PODOCYTE SHEDDING AND RENAL PROGNOSIS
Authors: Abe Makoto , Kaiga Akiko , Ohira Takehiro , Ishimitsu Toshihiko , Tojo Akihiro 
Published: January 2023

Objective:
Urinary podocyte excretion is related to a reduction in glomerular podocyte numbers, glomerulosclerosis, and urinary protein selectivity. To elucidate the factors of urinary podocyte shedding and renal prognosis, we examined urinary podocytes in 120 renal biopsy patients.

Design and method:
Podocytes were identified in urinary sediments stained with fluorescent-labelled anti-podocalyxin antibodies in ten high power fields. The amounts of protein bands, separated by SDS-polyacrylamide gel electrophoresis, were calculated using an image software program. The renal prognosis, including induction of hemodialysis or 30% reduction in eGFR, was investigated.

Results:
Urinary podocyte excretion showed a higher positive correlation with albumin excretion compared to IgG, prealbumin, and transferrin, but not with low molecular weight proteins, including beta2-microglobulin and alpha1-microglobulin. The hemodynamic pressure on the glomerular capillary wall, including products of pulse pressure and pulse rate (water hammer pressure), was positively correlated with urinary podocyte excretion. Urinary podocyte excretion and Tamm-Horsfall protein were independent risk factors for renal prognosis.

Conclusions:
Urinary podocytes shed from glomerular capillaries by water hammer and were involved in albuminuria and renal prognosis of renal biopsy patients.
PS-C13-10: A PROFILE OF OUT-OF-HOSPITAL CARDIAC ARREST IN AMANG RODRIGUEZ MEMORIAL MEDICAL CENTER: A PROSPECTIVE COHORT STUDY
Authors: Jesus Donna Erika Evangelista De 
Published: January 2023

Objective:
For every minute of cardiac arrest without early intervention, chances of survival drop by 7 to 10%. It is crucial that CPR be initiated within 4 to 6 minutes to avoid brain death. Most out-of-hospital cardiac arrests (OHCA) occur in a residential setting where access to trained personnel and equipment are not readily available, resulting to poor victim outcomes. The objective of the study is to present the different patient, responder, and transport factors affecting out-of-hospital cardiac arrest among adult patients brought to Amang Rodriguez Memorial Medical Center.

Design and method:
This is a descriptive study done from August to November 2021 using a prospective cohort design. Participants of the study include adult patients aged 18 years and above brought to the emergency room who suffered from out-of-hospital cardiac arrest. Descriptive statistics was used to summarize the demographic and clinical characteristics of the patients.

Results:
63 participants were included in the study. Majority were male patients at 73.02%. Hypertension was identified as the top co-morbidity. Medical causes of arrest were identified in 96.83% of the cases. 90.48% of cardiac arrests occurred at home. Only 26 patients (41.27%) received pre-hospital intervention prior to ER arrival in the form of hands-only CPR. 60.32% were brought via self-conduction, the remainder by ambulances, which had no available equipment necessary to provide proper resuscitation. Average travel time from dispatch to ER arrival is 20 minutes.

Conclusion:
Overall survival of OHCA in our local setting remain dismal, as return of spontaneous circulation was not achieved in any of the patients. The small number of patients having pre-hospital CPR indicates the need for emphasis on training and community education.
PS-C13-13: BLOOD PRESSURE REACTIVITY AGAINST PHYSICAL ACTIVITY “ACTISENSITIVITY” EVALUATED BY MULTISENSOR-ABPM CHANGES BEFORE AND AFTER TREATMENT OF HEART FAILURE
Authors: Narita Keisuke , Hoshide Satoshi , Kario Kazuomi 
Published: January 2023

Introduction:
The pathological significance of blood pressure (BP) variability in patients with heart failure (HF) has not been fully elucidated. We propose the term Actisensitivity to describe such BP reactivity in response to physical activity; this new aspect of BP variability can be evaluated using our recently developed device, a multisensor-ambulatory BP monitoring (ABPM) device (TM-2441, A&D Co., Tokyo) equipped with an actigraph that can detect physical movements.

Methods:
In the present study, actisensitivity is defined as the slope of the regression line that is calculated from ambulatory systolic BP (SBP) with the log-transformed value corresponding 5-min average of physical activity just before each BP measurement. We prospectively assessed the changes in actisensitivity and ambulatory BP (ABP) parameters between patients with and without improved cardiac function during the treatment of HF. We assessed 20 patients with diagnosed HF (mean ± SD age, 63.3 ± 14.1 years; male, 65%; ischemic heart disease, 15%; atrial fibrillation, 25%) just after initial or adjusted treatments, and reassessed the multisensor-ABPM data at follow-up from 6–12 months after tailored treatment. Second, we divided these patients into an improved (n = 11 patients) and a not-improved (n = 9) cardiac-function group; an increase in echocardiographic left ventricular ejection fraction of ≧ 10%. We then compared the changes in actisensitivity and ABP parameters between the two groups.

Results:
Parameters of ABP variability, i.e., SD, coefficient of variation, and average real variability of SBP, did not change between baseline and follow-up in either group. However, the actisensitivity value tended to increase from baseline to follow-up in the improved group (1.0 ± 3.5 vs. 4.5 ± 3.5, p = 0.065), but not in the not-improved group. The degree of changes in actisensitivity from baseline to follow-up tended to be higher in the improved group than the not-improved group (3.5 ± 5.6 vs. -1.2 ± 4.8, p = 0.059) (Figure). Moreover, in the overall patient group, the change of actisensitivity from baseline to follow-up was significantly related to the changes of LVEF (r = 0.553, p = 0.011).

Conclusion:
To our knowledge, this is the first study to prospectively observe the changes of novel BP reactivity against physical activity in HF patients using the new multisensor-ABPM device. Our findings should help to elucidate the relationships between BP variability/hemodynamics during physical activity and cardiac function in patients with HF.