bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond brain injury biomarkers: chemoattractants and circulating progenitor cells as biomarkers of endogenous rehabilitation effort in preterm neonates with encephalopathy
Authors: Efstathiou N. , Soubasi V. , Koliakos G. , Kantziou K. , Kyriazis G. , Slavakis A. , Dermentzoglou V. , Michalettou I. , Drosou-Agakidou V. 
Published: May 2023

IntroductionPreclinical work and studies in adults have shown that endogenous regeneration efforts that involve mobilization of progenitor cells take place after brain injury. However, kinetics of endogenous circulating progenitor cells (CPCs) in preterm neonates is not well described, particularly their possible role regarding brain injury and regeneration. We aimed to assess the kinetics of CPCs in neonates with encephalopathy of prematurity in relation to brain injury biomarkers, chemoattractants and relevant antenatal and postanal clinical factors, in an effort to outline the related pathophysiology.Materials and methods47 preterm neonates (of 28–33 weeks GA) were enrolled: 31 newborns with no or minimal brain injury (grade I IVH) and 16 prematures with encephalopathy (grade III or IV IVH, PVL or infarct). Peripheral blood samples obtained on days 1, 3, 9, 18 and 45 after birth were analyzed using flow cytometry, focusing on EPCs (early and late Endothelial Progenitor Cells), HSCs (Hematopoietic Stem Cells) and VSELs (Very Small Embryonic-Like Stem Cells). At the same time-points serum levels of S100B, Neuron-specific Enolase (NSE), Erythropoietin (EPO), Insulin-like growth factor-1 (IGF-1) and SDF-1 were also measured. Neonates were assessed postnatally with brain MRI, and with Bayley III developmental test at 2 years of corrected age.ResultsPreterms with brain injury proved to have significant increase of S100B and NSE, followed by increase of EPO and enhanced mobilization mainly of HSCs, eEPCs and lEPCs. IGF-1 was rather decreased in this group of neonates. IGF-1 and most CPCs were intense decreased in cases of antenatal or postnatal inflammation. S100B and NSE correlated with neuroimaging and language scale in Bayley III test, providing good prognostic ability.ConclusionThe observed pattern of CPCs’ mobilization and its association with neurotrophic factors following preterm brain injury indicate the existence of an endogenous brain regeneration process. Kinetics of different biomarkers and associations with clinical factors contribute to the understanding of the related pathophysiology and might help to early discriminate neonates with adverse outcome. Timely appropriate enhancement of the endogenous regeneration effort, when it is suppressed and insufficient, using neurotrophic factors and exogenous progenitor cells might be a powerful therapeutic strategy in the future to restore brain damage and improve the neurodevelopmental outcome in premature infants with brain injury.
Posttraumatic stress disorder symptoms among healthcare workers during the Omicron era
Authors: Yin YuanYuan , Han Sizhu , Guan Jiaoqiong , Wang DuanWei , Wang HaiRong , Yuan Ti-Fei , Yang Ying 
Published: May 2023

BackgroundThe COVID-19 pandemic has caused significant psychological stress among healthcare workers. This study aimed to clarify the factors that influenced health workers’ posttraumatic stress disorder (PTSD) symptoms.MethodA total of 443 healthcare workers from eight Mental Health Centers in Shandong were recruited to attend an online survey. Participants completed self-evaluation measures of exposure to the COVID-19 environment and PTSD symptoms, as well as measures of potential protective factors such as euthymia and perceived social support.ResultsAbout 45.37% of healthcare workers had severe symptoms of PTSD symptoms. Healthcare workers with more serious PTSD symptoms were significantly related to higher exposure to COVID-19 (r = 0.177, p &lt; 0.001), as well as lower levels of euthymia (r = −0.287, p &lt; 0.001) and perceived social support (r = −0.236, p &lt; 0.001). The structural equation model (SEM) further revealed that the impact of exposure to COVID-19 on PTSD symptoms was partially mediated by euthymia, and moderated by perceived social support, especially from others (e.g., friends, leaders, relatives and colleagues).ConclusionThese findings suggested that improving the state of euthymia, getting social support from others could alleviate PTSD symptoms among healthcare workers during the COVID-19.
Psychometric properties of the Italian version of the staff attitude to coercion scale: an exploratory factor analysis
Authors: Venturini Paola , Bassi Giulia , Salcuni Silvia , Kotzalidis Georgios D. , Telesforo Carla Ludovica , Salustri Eleonora , Trevisi Manuela , Roselli Valentina , Tarsitani Lorenzo , Infante Vittorio , Niolu Cinzia , Polselli Gianmarco , Boldrini Tommaso 
Published: May 2023

AimsThe current study aimed to validate the Italian version of the Staff Attitude to Coercion Scale (SACS), which assesses mental health care staff’s attitudes to the use of coercion in treatment.MethodsThe original English version of the SACS was translated into Italian, according to the back-translation procedure. Subsequently, it was empirically validated by performing an exploratory factor analysis on a sample of 217 mental health professionals (Mean = 43.40 years, SD = 11.06) recruited form Italian general hospital (acute) psychiatric wards (GHPWs), with at least 1 year of work experience (i.e., inclusion criteria).ResultsResults confirmed the three-factor solution of the original version for the Italian version of the SACS, though three items loaded on different factors, compared to the original. The three extracted factors, explained 41% of total variance, and were labeled similarly to the original scale and according to their respective item content, i.e., Factor 1 “Coercion as offending” (items: 3, 13, 14, and 15), Factor 2 “Coercion as care and security” (items: 1, 2, 4, 5, 7, 8, and 9), and Factor 3 “Coercion as treatment” (items: 6, 10, 11, and 12). The internal consistency of the three-factor model of the Italian version of the SACS was assessed through Cronbach’s α and yielded acceptable indexes, ranging from 0.64 to 0.77.ConclusionThe present findings suggest that the Italian version of the SACS is a valid and reliable tool that can be used to assess healthcare professionals’ attitudes toward coercion.
Developing and evaluating a professional development plan pilot for doctors in unaccredited posts: A pilot study
Authors: Thistlethwaite Jill , McGirr Lara , Vial Toni 
Published: May 2023

Purpose

In Australia, doctors from their third-year post graduation who are not on specialist training pathways frequently work in unaccredited posts with varying amounts of education and support. In 2019, the New South Wales Ministry of Health (NSW Health) and the Health Education and Training Institute (HETI) agreed on a pilot process for these doctors to develop a professional development plan (PDP). The pilot aimed to implement the process and evaluate its feasibility and acceptability.

Methodology/approach

The process was piloted at four sites in 2021. The evaluation methodology was informed by the non-adoption, abandonment and challenges to scale-up, spread and sustainability (NASSS) framework with data derived from site meetings, interviews with doctors in unaccredited positions and PDP supervisors, and analysis of PDPs and time required.

Findings

A total of 42 doctors undertook the PDP process, of whom 25 were interviewed. Of the 28 supervisors recruited, 13 were interviewed. Three sites reported successful implementation, with most doctors having a PDP in progress. Despite challenges associated with the diversity of the workforce and workplaces, all sites were supportive of the process being rolled out with appropriate resourcing.

Research implications

The research findings indicated that embedding a PDP process more widely across the state will be complex due to the diversity of the workforce and clinical workplaces.

Practical implications

The PDP process, while acceptable and feasible, needs to adapt to local circumstances, including the workforce, supervisory capacity and experience, individual doctor needs and available resources.

Originality

The evaluation supports the need for a supported PDP process for doctors in unaccredited positions.

Limitations

The findings may not be transferable to all NSW Health facilities or to other states or territories. Doctors who consented to be interviewed were more likely to be positive about the process than those who did not. The study did not include a cost evaluation or explore cost-effectiveness due to the short time frame.
Energy Metabolism Dysregulation in Chronic Kidney Disease
Authors: Li Ying , Gu Wanjun , Hepokoski Mark , Pham Hai , Tham Rick , Kim Young Chul , Simonson Tatum S. , Singh Prabhleen 
Published: May 2023

Key Points

There is significant enrichment in metabolic pathways in early stages in the subtotal nephrectomy model of CKD.Proximal tubular mitochondrial respiration is suppressed likely from mitochondrial dysfunction in substrate utilization and ATP synthesis.There is significant suppression of pyruvate dehydrogenase and increased glycolysis in proximal tubules.

Background
CKD is a significant contributor to morbidity and mortality. A better understanding of mechanisms underlying CKD progression is indispensable for developing effective therapies. Toward this goal, we addressed specific gaps in knowledge regarding tubular metabolism in the pathogenesis of CKD using the subtotal nephrectomy (STN) model in mice.

Methods
Weight- and age‐matched male 129X1/SvJ mice underwent sham or STN surgeries. We conducted serial GFR and hemodynamic measurements up to 16 weeks after sham and STN surgery and established the 4-week time point for subsequent studies.

Results
For a comprehensive assessment of renal metabolism, we conducted transcriptomic analyses, which showed significant enrichment of pathways involved in fatty acid metabolism, gluconeogenesis, glycolysis, and mitochondrial metabolism in STN kidneys. Expression of rate-limiting fatty acid oxidation and glycolytic enzymes was increased in STN kidneys, and proximal tubules in STN kidneys exhibited increased functional glycolysis but decreased mitochondrial respiration, despite an increase in mitochondrial biogenesis. Assessment of the pyruvate dehydrogenase complex pathway showed significant suppression of pyruvate dehydrogenase, suggesting decreased provision of acetyl CoA from pyruvate for the citric acid cycle to fuel mitochondrial respiration.

Conclusion
Metabolic pathways are significantly altered in response to kidney injury and may play an important role in the disease progression.
PENCEGAHAN PENYEBARAN BERITA HOAX TENTANG PESAN BERANTAI PENCULIKAN DI DAERAH TANGERANG, BANTEN
Authors: Meilinda Vivi 
Published: May 2023

Dengan semakin banyaknya orang yang memiliki akses ke internet, hoax menjadi semakin umum di Indonesia. yang mengejutkan, ibu rumah tangga merupakan mayoritas penyebar hoax, salah satu penyebab dari dampak buruk penggunaan internet, seperti berita palsu, pelanggaran privasi, cyberbullying, konten kekerasan, dan pornografi adalah rendahnya literasi media digital. mayoritas dari ratusan berita palsu tersebut melibatkan penipuan di bidang teknologi informasi (fintech), politik, kesehatan, atau bencana alam. kegagalan masyarakat dalam melakukan pengecekan fakta di media sosial memiliki dampak yang serius. Polisi dapat menjerat mereka dengan pelanggaran UU ITE karena saat ini masih minimnya pengetahuan tentang deteksi hoax, kegiatan ini berpusat pada pemberdayaan masyarakat melalui literasi media digital.
ДО ВИЗНАЧЕННЯ ГАЛЬМІВНИХ ВЛАСТИВОСТЕЙ АВТОПОЇЗДА З ЧАСТКОВО ЗАПОВНЕНОЮ ЦИСТЕРНОЮ
Authors: САХНО Володимир , МУРОВАНИЙ Ігор , ПОЛЯКОВ Віктор , ПОПЕЛИШ Денис 
Published: May 2023

Збільшення обсягів перевезень і розширення номенклатури перевезених вантажів, що перевозяться вимагають удосконалення структури і продуктивності автотранспортних засобів (АТЗ). Суттєвим резервом підвищення ефективності використання АТЗ є збільшення кількості вантажів, що перевозяться автопоїздами без значного збільшення їх кількості на автомобільних дорогах. Вирішити цю проблему можна за допомогою великотоннажних автопоїздів, у тому числі багатоланкових. У зв'язку з цим одним із найважливіших завдань є необхідність забезпечення таких автопоїздів необхідним рівнем гальмівних властивостей.
У роботі показано, що при частково заповненій цистерні змінюються динамічні якості колісних транспортних засобів внаслідок великих переміщень центру мас вантажу в резервуарі, що призводить до додаткових навантажень, що діють на конструкцію цистерни, а також суттєвого зниження стійкості, керованості і гальмівних властивостей транспортних засобів, що визначаються нормальними реакціями опорної поверхні на його колеса (осі). У роботі визначені нормальні реакції опорної поверхні для різного ступеня заповнення цистерни і для автопоїзда з жорстким вантажем. Розділення внутрішнього об`єму цистерни на окремі секції майже не впливає на максимальне значення сили інерції у разі гальмування автопоїзда із сталим уповільненням, але при цьому частота коливань цієї сили є більшою. При цьому рух рідини відносно цистерни призводить до зменшення гальмівного шляху. Поділ цистерни на секції, як і ступінь її заповнення також впливають на довжину шляху – найкоротший у автопоїзда з односекційною цистерною із 50% наповненням.
Ключові слова: автопоїзд, цистерна, ступінь заповнення, секційність цистерни, нормальна реакція, уповільнення, гальмівний шлях
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PRESTASI KERJA KARYAWAN PADA PT BPR GUNUNG SLAMET CILACAP
Authors: Hasanah Nurul , Kurniawan Satrio Agung 
Published: May 2023

ABSTRACTThe research is entitled “Analysis of Factors Influencing Employees’ Performance at the PT BPR Gunung Slamet, Cilacap”. The objective of the research is to analyze the enfluense of organization culture, organizational commitment, and work experience upon job performance of employees’ working at the PT BPR Gunung Slamet, Cilacap. The proposed hypothesis is organization culture, commitment organizational, and work experience in parsial influences employees’ performance. Instrument of analysis employed in the research is multiple linear regression and determination coefficient.Keywords:Organization Culture;Commitment Organizational;Work Experience;Work Achievement. Penelitian ini mengambil judul “Analisis Faktor-Faktor Yang Mempengaruhi Prestasi Kerja Karyawan Pada PT BPR Gunung Slamet Cilacap”. Tujuan dalam penelitian ini adalah untuk Mengetahui dan menganalisis pengaruh budaya organisasi , komitmen organisasi, dan pengalaman kerja secara signifikan terhadap prestasi kerja karyawan pada PT BPR Gunung Slamet Cilacap. Hipotesis yang dikemukakan adalah: Satu, Budaya Organisasi Berpengaruh Secara Signifikan Terhadap Prestasi Kerja Karyawan Pada PT BPR Gunung Slamet Cilacap; Dua, Komitmen Organisasi Berpengaruh Secara Signifikan Terhadap Prestasi Kerja Karyawan Pada PT BPR Gunung Slamet Cilacap; Tiga, Pengalaman Kerja Berpengaruh Secara Signifikan Terhadap Prestasi Kerja Karyawan Pada PT BPR Gunung Slamet Cilacap. Analisis yang digunakan untuk menguji hipotesis penelitian ini adalah Analisis regresi linier berganda dan koefisien determinasi.Kata Kunci: Budaya Organisasi; Komitmen Organisasi; Pengalaman Kerja; Prestasi Kerja.
PENGARUH STRES KERJA DAN KOMITMEN ORGANISASIONAL TERHADAP KINERJA PEGAWAI PADA SEKRETARIAT DAERAH KABUPATEN TASIKMALAYA
Authors: Wibisino Taufik 
Published: May 2023

The purpose of this study was to know and analyze the stress of work and organizational commitment and employee performance, and the effect of work stress and organizational commitment to employee performance at the District Secretariat Tasikmalaya regency. The method used is a survey method. The procedure of collecting data obtained through interviews, questionnaires and literature. The sampling technique used purposive sampling with a population of civil servants in the Office of the Regional Secretariat of Tasikmalaya regency as many as 100 people. Data analysis technique used is path analysis. The analysis showed that work stress and organizational commitment and employee performance significantly influence employee performance Tasikmalaya regency Regional Secretariat either partially or simultaneously. Employees should be able to manage job stress wisely. Keywords: job stress, organizational commitment, employee performanceTujuan penelitian ini adalah mengetahui dan menganalisis mengenai stres kerja dan komitmen organisasional serta kinerja pegawai,dan pengaruh stres kerja dan komitmen organisasional terhadap kinerja pegawai pada Sekretariat Daerah KabupatenTasikmalaya. Metode penelitian yang digunakan adalah metode survey. Prosedur pengumpulan data diperoleh melalui wawancara, kuesioner dan studi pustaka. Teknik pengambilan sampel menggunakan porposive samplingdengan populasi pegawai negeri sipil di lingkungan Kantor Sekretariat Daerah Kabupaten Tasikmalaya sebanyak 100 orang. Teknik analisis data yang digunakan adalah analisis jalur. Hasil analisis menunjukkan bahwa stres kerja dan komitmen organisasional serta kinerja pegawai berpengaruh signifikan terhadap kinerja pegawai pada Sekretariat Daerah KabupatenTasikmalayabaik secara parsial maupun simultan. Sebaiknya pegawai mampu mengelola stress kerja secara bijaksana. Kata kunci: stres kerja, komitmen organisasional, kinerja pegawai.
PENGARUH STRUKTUR MODAL DAN UKURAN PERUSAHAAN TERHADAP PROFITABILITAS PADA PERUSAHAAN OTOMOTIF YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Lorenza Dhea , Kadir Muh Akob , Sjahruddin Herman 
Published: May 2023

we sought to analyze the impact of capital structure and company size on the profitability of automotive companies listed on the Indonesian Stock Exchange over the period 2015-2018. The sample in this study consisted of 14 sampling companies using the method sampling. The analytical tool used is a multiple linear regression analysis aimed at analyzing the relationship between capital structure variables and firm size to profitability using SPSS v.25 software.The results show that the capital structure (DER) has a negative effect and the firm's size has no significant effect on profitability. This study has limitations in the number of data units and only uses automotive sub-companies, thus limiting the research. This research has practical implications for investors and management companies in making financial decisions related to observed variables. Previous research has largely analyzed the profitability of the company, this study shows the results of two factors that are tested with similar (negative) results in the modeling so that they can be used as the originality of this study.Keywords: debt to equity ratio; total assets; return on assetKami mencoba menganalisis pengaruh struktur modal dan ukuran perusahaan terhadap profitabilitas pada perusahaan otomotif yang terdaftar di Bursa Efek Indonesia periode 2015-2018. Sampel pada penelitian ini terdiri dari 14 perusahaan dan penarikan sampel yang dilakukan menggunakan metode purposive sampling. Alat analisis yang digunakan adalah analisis regresi linear berganda yang bertujuan untuk menganalisis hubungan antara variabel struktur modal dan ukuran perusahaan terhadap profitabilitas dengan menggunakan software SPSS v.25.Hasil penelitian menunjukkan bukti bahwa struktur modal (DER) berpengaruh negatif dan ukuran perusahaan berpengaruh tidak signifikan terhadap profitabilitas. Penelitian ini memiliki keterbatasan pada jumlah unit data dan hanya menggunakan perusahaan sub-sektor otomotif saja sehingga membatasi penelitian ini. Penelitian ini berimplikasi secara praktis kepada investor dan manajemen perusahaan dalam mengambil keputusan keuangan terkait dengan variabel yang diamati. Penelitian terdahulu sangat banyak yang menganalisis profitabilitas perusahaan, penelitian ini menunjukkan hasil dari kedua kausalitas yang diuji dengan hasil yang serupa (negative) dalam suatu pemodelan sehingga dapat digunakan sebagai orisinalitas penelitian ini.Kata Kunci: debt to equity ratio; total aset; return on asset
PENGARUH ALOKASI KREDIT DAN HARGA KREDIT TERHADAP PROFITABILITAS DENGAN RISIKO KREDIT SEBAGAI VARIABEL INTERVENING
Authors: Mulyani Elis Listiana , Sari Dewi Permata , Mufreni Alfin Nurfahmi 
Published: May 2023

The purpose of this study is to find out and analyze the effect of credit ratio(Loan to Funding Ratio /Â LFR) and credit price (Loan Pricing) on profitability (Net Profit Margin) with credit risk (NonÂ Performing Loan / NPL) as Intervening Variable. The research was conducted on banking listed onÂ the Indonesia Stock Exchange.The research method used is descriptive analysis with the data used is secondary data in the form ofÂ Income and Balance Sheet statements on banks listed on the Indonesia Stock Exchange. AnalyticalÂ tools use financial ratios in the form of Loan to Funding Ratio (LFR), Loan Pricing, Credit RiskÂ (Non Performing Loan) and Net Profit Margin and intervening regression analysis.Based on the results of research it is known that Credit Risk (NPL) becomes a partial interveningÂ variable between Loan Funding Rastio against Net Profit Margin (NPM), while between CreditÂ Price (Loan Pricing)against Net Profit Margin, Credit Risk (NPL) becomes a perfect interveningÂ variable. Tujuan Penelitian ini adalah untuk mengetahui dan menganalisis pengaruh rasio kredit (Loan toÂ Funding Ratio /LFR) dan harga kredit (Loan Pricing) terhadap profitabilitas (Net Profit Margin)Â dengan risiko kredit (Non Performing Loan/NPL) sebagai Variabel Intervening .Penelitian dilakukanÂ pada Perbankan yang tercatat di Bursa Efek Indonesia.Metode Penelitian yang digunakan adalah analisis deskriptif dengan data yang digunakan adalah dataÂ sekunder berupa laporan Keuangan Laba Rugi dan Neraca pada Perbankan yang tercatat di BursaÂ Efek Indonesia .Alat analisis menggunakan rasio keuangan berupa Loan to Funding Ratio (LFR),Â Loan Pricing ( Harga Kredit) , Risiko Kredit ( Non Performing Loan) dan Net Profit Margin danÂ analisis regressi intervening . Berdasarkan hasil penelitian diketahui bahwa bahwa Risiko Kredit (NPL) menjadiÂ variableÂ intervening parsial antara Loan Funding Rastio terhadap Net Profit Margin (NPM), sedangkan antara Harga Kredit ( Loan Pricing) terhadap Net Profit Margin, Risiko Kredit (NPL) menjadivariable intervening sempurna .
Vertrauen und Kontrolle im Rahmen der Integrierten Projektabwicklung (IPA)/Trust and Control in the context of Integrated Project Delivery
Authors: Haghsheno Shervin , Väth Cornelius , Schmidt Jan-Simon , Hanau Anna , Budau Maximilian R.-D. , Frantz Lena 
Published: May 2023

Im Ausland kommen seit vielen Jahren erfolgreich Projektabwicklungsmodelle wie „Project Alliancing“ und „Integrated Project Delivery“ zum Einsatz. Diese Modelle unterscheiden sich insbesondere durch frühe Integration wesentlicher Projektbeteiligter und auf den Projekterfolg ausgerichtete gemeinsame Anreizsysteme von traditionellen Modellen. In Deutschland werden diese Modelle unter dem Begriff „Integrierte Projektabwicklung“ (IPA) subsumiert.

Die erfolgreiche Umsetzung von IPA erfordert in der Regel ein hohes Maß an Vertrauen. Gleichzeitig kann eine gewisse Form der Kontrolle sinnvoll oder dringend erforderlich sein. Der folgende Beitrag geht daher der Frage nach, welche Elemente den Grad des Vertrauens zwischen den Partnern in einem IPA-Projekt beeinflussen und inwieweit im Gegenzug Kontrolle erforderlich ist. Dazu wurden Aspekte der IPA, die Vertrauen erfordern beziehungsweise beeinflussen, identifiziert und deren Ausgestaltung in Abhängigkeit vom Vertrauensgrad analysiert.