ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample: the SAPRIS-SERO multi-cohort study
Authors: Deschasaux-Tanguy Mélanie , Szabo de Edelenyi Fabien , Druesne-Pecollo Nathalie , Esseddik Younes , Allègre Julien , Srour Bernard , Galan Pilar , Hercberg Serge , Severi Gianluca , Zins Marie , Wiernik Emmanuel ,   SAPRIS-SERO study group,   SAPRIS-SERO coordination, Carrat Fabrice , Ancel Pierre-Yves , Bajos Nathalie , Charles Marie-Aline , Severi Gianluca , Touvier Mathilde , Zins Marie ,   Constances cohort, Kab Sofiane , Renuy Adeline , Le Got Stéphane , Ribet Céline , Pellicer Mireille , Wiernik Emmanuel , Goldberg Marcel , Zins Marie ,   E3N-E4N cohort, Artaud Fanny , Gerbouin-Rérolle Pascale , Enguix Mélody , Laplanche Camille , Gomes-Rimav Roselyn , Hoang Lyan , Correia Emmanuelle , Barry Alpha Amadou , Senina Nadège , Severi Gianluca ,   NutriNet-Santé cohort, de Edelenyi Fabien Szabo , Allègre Julien , Druesne-Pecollo Nathalie , Esseddik Younes , Hercberg Serge , Touvier Mathilde ,   Epipage2 and Elfe child cohorts, Charles Marie-Aline , Ancel Pierre-Yves , Benhammou Valérie , Ritmi Anass , Marchand Laetitia , Zaros Cecile , Lordmi Elodie , Candea Adriana , de Visme Sophie , Simeon Thierry , Thierry Xavier , Geay Bertrand , Dufourg Marie-Noelle , Milcent Karen ,   IPLESP – methodology and coordinating data center, Lusivika-Nzinga Clovis , Pannetier Gregory , Lapidus Nathanael , Goderel Isabelle , Dorival Céline , Nicol Jérôme , Robineau Olivier , Carrat Fabrice ,   Inserm, Lai Cindy , Belhadji Liza , Esperou Hélène , Couffin-Cadiergues Sandrine ,   Institut de Santé Publique, Gagliolo Jean-Marie ,   CEPH-Biobank, Blanché Hélène , Sébaoun Jean-Marc , Beaudoin Jean-Christophe , Gressin Laetitia , Morel Valérie , Ouili Ouissam , Deleuze Jean-François ,   Unité des Virus Emergents, Priet Stéphane , Villarroel Paola Mariela Saba , Fourié Toscane , Ali Souand Mohamed , Amroun Abdenour , Seston Morgan , Ayhan Nazli , Pastorino Boris , de Lamballerie Xavier , de Lamballerie Xavier , Carrat Fabrice , Touvier Mathilde 
Published: March 2023

AbstractABO blood type has been reported as a potential factor influencing SARS-CoV-2 infection, but so far mostly in studies that involved small samples, selected population and/or used PCR test results. In contrast our study aimed to assess the association between ABO blood types and SARS-CoV-2 infection using seroprevalence data (independent of whether or not individuals had symptoms or sought for testing) in a large population-based sample. Our study included 67,340 French participants to the SAPRIS-SERO multi-cohort project. Anti-SARS-CoV-2 antibodies were detected using ELISA (targeting the proteins spike (S) and nucleocapsid (NP)) and seroneutralisation (SN) tests on dried blood spots collected in May–November 2020. Non-O individuals (and especially types A and AB) were more likely to bear anti SARS-CoV-2 antibodies (ELISA-S, 2964 positive cases: ORnon-Ovs.O = 1.09[1.01–1.17], ORAvs.O = 1.08[1.00–1.17]; ELISA-S/ELISA-NP/SN, 678 triple positive cases: ORnon-Ovs.O = 1.19 [1.02–1.39], ORAvs.O = 1.19[1.01–1.41], ORABvs.O = 1.43[1.01–2.03]). Hence, our results provided additional insights into the dynamic of SARS-CoV-2 infection, highlighting a higher susceptibility of infection for individuals of blood types A and AB and a lesser risk for blood type O.