bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Harmonic Generation from Crystalline and Amorphous Gallium Phosphide Nanofilms
Authors: Tilmann Benjamin , Huq Tahiyat , Possmayer Thomas , Dranczewski Jakub , Nickel Bert , Zhang Haizhong , Krivitsky Leonid , Kuznetsov Arseniy I. , de S. Menezes Leonardo , Vezzoli Stefano , Sapienza Riccardo , Maier Stefan A. 
Published: June 2023

AbstractGallium phosphide (GaP) is a promising material for nanophotonics, given its large refractive index and a transparency over most of the visible spectrum. However, since easy phase‐matching is not possible with bulk GaP, a comprehensive study of its nonlinear optical properties for harmonic generation, especially when grown as thin films, is still missing. Here, second harmonic generation is studied from epitaxially grown GaP thin films, demonstrating that the absolute conversion efficiencies are comparable to a bulk wafer over the pump wavelength range from 1060 to 1370 nm. Furthermore, the results are compared to nonlinear simulations, and the second order nonlinear susceptibility is extracted, showing a similar dispersion and magnitude to that of the bulk material. Furthermore, the third order nonlinear susceptibility of amorphous GaP thin films is extracted from third harmonic generation to be more than one order of magnitude larger than that of the crystalline material, and generation of up to the fifth harmonic is reported. The results show the potential of crystalline and amorphous thin films for nonlinear optics with nanoantennas and metasurfaces, particularly in the visible to near infrared part of the spectrum.
Normalizing Input–Output Relationships of Cancer Networks for Reversion Therapy
Authors: Joo Jae Il , Park Hwa‐Jeong , Cho Kwang‐Hyun 
Published: June 2023

AbstractAccumulated genetic alterations in cancer cells distort cellular stimulus‐response (or input–output) relationships, resulting in uncontrolled proliferation. However, the complex molecular interaction network within a cell implicates a possibility of restoring such distorted input–output relationships by rewiring the signal flow through controlling hidden molecular switches. Here, a system framework of analyzing cellular input–output relationships in consideration of various genetic alterations and identifying possible molecular switches that can normalize the distorted relationships based on Boolean network modeling and dynamics analysis is presented. Such reversion is demonstrated by the analysis of a number of cancer molecular networks together with a focused case study on bladder cancer with in vitro experiments and patient survival data analysis. The origin of reversibility from an evolutionary point of view based on the redundancy and robustness intrinsically embedded in complex molecular regulatory networks is further discussed.
Human adaptation to cold and warm climatic conditions: A comparison between two geographically diverse Indigenous populations
Authors: Ghosh Sudipta 
Published: June 2023

AbstractObjectivesThe present study aims to compare body adiposity and blood pressure (BP) in two climatically and ethnically diverse populations, examining whether thermoregulatory adaptive mechanism may protect Indigenous populations from exhibiting adverse consequences of increased adiposity.MethodsA cross sectional sample of 404 subjects, of which 200 were Monpa and 204 were Santhal, from two ethnically and geographically distinct populations of India were studied. Body mass index (BMI; kg/m2), fat mass (FM; kg), fat free mass (kg), and percent body fat (%BF) were calculated for evaluation of body adiposity. Multivariate multiple regression analysis was adopted to examine the influence of age and sex of populations under study, on body adiposity and BP variables.ResultsBMI, %BF, and FM were found to be significantly higher (p ˂ .001) among the Monpa males and females compared with their Santhal counterparts. In contrast, the prevalence of hypertension among Monpa and Santhal is comparable (3.5%Monpa vs. 3.9%Santhal for systolic BP; 8.5%Monpa vs. 8.3%Santhal for diastolic BP). Adiposity, as quantitated by the fat mass index and %BF was significantly (p ˂ .001) correlated to age and sex of study population, explaining ~75.3% and ~75.4% of total variations of these variables, respectively.ConclusionsOverall the present study suggests that modern human populations follow thermoregulatory mechanism for adaptation to different climatic conditions. Consequently, greater adiposity was evident among the Monpa who adapt to the cold climate, in comparison to their Santhal counterparts who dwell in warm climate.
Steered Quantum Coherence as a Signature of Topological Quantum Phase Transitions in the Extended XY Model
Authors: Du Ming‐Ming , Gu Shi‐Pu , Zhong Wei , Yan Xiao‐Jing , Zhou Lan , Sheng Yu‐Bo 
Published: June 2023

AbstractIn recent years, there has been a surge of interest in exploring coherence measures and correlation measures to characterize topological quantum phase transitions (TQPTs). Here, motivated by the continued push in this direction, the steered quantum coherence (SQC) in the extended XY model is studied to analyze its capability in characterizing TQPTs. It is shown that the first derivative of SQC succeeds in signaling different critical points of TQPTs. In particular, it is found that the SQC is a long‐range correlation and the first derivative of SQC can always accurately identify TQPTs for different site distance.
Mit sichtbarem Licht schaltbare Benzimidazol‐Azo‐Arene wirken als β‐Arrestin2 funktionell selektive Cannabinoid‐Rezeptor 2 Agonisten
Authors: Steinmüller Sophie A. M. , Fender Julia , Deventer Marie H. , Tutov Anna , Lorenz Kristina , Stove Christophe P. , Hislop James N. , Decker Michael 
Published: June 2023

AbstractDer Cannabinoid 2 Rezeptor (CB2R) besitzt großes therapeutisches Potential bei zahlreichen pathophysiologischen Prozessen wie z. B. der Neuroinflammation. Signalweg‐selektive Liganden werden benötigt, um mangelnden klinischen Erfolg zu überwinden und um die Zusammenhänge zwischen einzelnen Signalwegen und deren therapeutischen Effekten zu beleuchten. Hier berichten wir vom Design und der Synthese eines photoschaltbaren chemischen Gerüsts basierend auf der “privilegierten” Struktur des Benzimidazols und seiner Anwendung als funktionell selektiven CB2R “Wirksamkeitsschalter” (”efficacy switch”). Benzimidazol‐Azo‐Arene bieten großes Potential für eine breite Erweiterung der Photopharmakologie auf eine Vielzahl optisch adressierbarer biologischer Zielstrukturen. Wir haben dieses Gerüst verwendet, um Substanz 10 d zu entwickeln, ein “trans‐on” Agonist, der als molekulare Sonde dient, um den β‐Arrestin2 (βArr2) Signalweg am CB2R zu untersuchen. Die selektive Aktivierung des βΑrr2 Signalweges wurde mittels CB2R Internalisierung und βArr2 Rekrutierung nachgewiesen, während keine Aktivierung bei der Betrachtung von Gα16 oder mini‐Gαi auftrat. Insgesamt stellt Substanz 10 d den ersten Licht‐abhängigen funktionell selektiven Agonisten dar, mit dem die komplexen βArr2‐abhängigen Mechanismen der Endozytose am CB2R untersucht werden können.
Visible‐Light Photoswitchable Benzimidazole Azo‐Arenes as β‐Arrestin2‐Biased Selective Cannabinoid 2 Receptor Agonists
Authors: Steinmüller Sophie A. M. , Fender Julia , Deventer Marie H. , Tutov Anna , Lorenz Kristina , Stove Christophe P. , Hislop James N. , Decker Michael 
Published: June 2023

AbstractThe cannabinoid 2 receptor (CB2R) has high therapeutic potential for multiple pathogenic processes, such as neuroinflammation. Pathway‐selective ligands are needed to overcome the lack of clinical success and to elucidate correlations between pathways and their respective therapeutic effects. Herein, we report the design and synthesis of a photoswitchable scaffold based on the privileged structure of benzimidazole and its application as a functionally selective CB2R “efficacy‐switch”. Benzimidazole azo‐arenes offer huge potential for the broad extension of photopharmacology to a wide range of optically addressable biological targets. We used this scaffold to develop compound 10 d, a “trans‐on” agonist, which serves as a molecular probe to study the β‐arrestin2 (βarr2) pathway at CB2R. βΑrr2 bias was observed in CB2R internalization and βarr2 recruitment, while no activation occurred when looking at Gα16 or mini‐Gαi. Overall, compound 10 d is the first light‐dependent functionally selective agonist to investigate the complex mechanisms of CB2R‐βarr2 dependent endocytosis.
Preparation of spherical phenol‐formaldehyde beads from phenol‐liquefied wood and the characteristics of carbonized materials
Authors: Lee Wen‐Jau , Hsiao Nien‐Chih , Chen Yi‐Chun 
Published: June 2023

AbstractIn this study, wood of Cryptomeria japonica D. Don (Japanese fir) was liquefied with phenol as a solvent. Phenol‐liquefied wood was mixed with formalin and spherical phenol‐formaldehyde resin (PF) beads were prepared by a two‐stage suspension polymerization reaction. The influence of the kind and dosage of polyvinyl alcohol (PVA) on the particle size distribution, mechanical strength and thermal properties of spherical PF beads were investigated. The results show that PF beads prepared with partially saponified PVA as a granulating agent are smaller than 75 μm, while the PF beads prepared with fully saponified PVA have larger diameters. However, the average diameter of spherical PF beads decreased with the increase of PVA addition. Thermogravimetric analysis (TGA) indicates that the initial thermal degradation temperature of the PF beads is around 150°C, and the main weight loss occurs between 400 and 600°C. Among them, the PF beads with BF‐04 as the granulating agent have the best heat resistance, and have the highest char yield at 800°C. The Brunauer, Emmett and Teller surface adsorption shows that the internal structure of the carbonized spherical PF beads is microporous pores. Carbonized beads prepared with high PVA adding have large absorption volume.
Effect of oxygen content on the preoxidation structure of polyacrylonitrile fibers
Authors: Zhou Hang , Lan Zecheng , Xiao Jing , Wang Yu , Xu Lianghua 
Published: June 2023

AbstractDuring the preoxidation process of polyacrylonitrile (PAN) fibers, the diffusion behavior of oxygen from skin to core can lead to the formation of radially uneven structure of fibers, which affects the mechanical properties of subsequent PAN carbon fibers. Here we examine the effect of oxygen content on the subsequent structure evolution of fibers with different preoxidation structure, by using13C Solid‐state NMR analysis (13C‐NMR), optical density characterization, differential scanning calorimetry analysis, and thermalgravimetric analysis. The results show that increasing the oxygen content during the subsequent heat treatment can effectively reduce the radial structure difference of fiber, its efficiency is related to the preoxidation degree of fibers. For fibers with lower preoxidation degree, namely less heat treatment work (W), the radial structure difference disappears when the oxygen content reaches 29%. Further study shows that the improvement of radial structure of preoxidized fibers improved fiber thermal stability, its efficiency is also related to theWof fibers; when theWof fibers is 5, the carbonization yield at 800°C increased from 56.79% to 62.61%, which is 10.25% higher; when theWof fibers is 20, under the same oxygen content range, the carbonization yield increased from 68.97% to 69.60%, which is only 0.913% higher.
Step by step progress to achieve an icephobic silicone‐epoxy hybrid coating: Tailoring matrix composition and additives
Authors: Adja Akré Anne Simone , Sobhani Sarah , Momen Gelareh , Fofana Issouf , Carrière Julie 
Published: June 2023

AbstractThis study details the fabrication of an icephobic coating for steel produced using a silicone–epoxy hybrid resin; the coating has good mechanical properties and weathering resistance for outdoor applications. Silicone–epoxy hybrid resins and amino‐functional silane‐curing agents were selected for investigation and applied to steel samples. Wettability, ice adhesion strength, and the mechanical and weathering resistance properties of the developed coatings were assessed using a drop‐shape analyzer, Fourier transform infrared, X‐ray photoelectron spectroscopy, as well as push‐off, tensile, and QUV tests. The possible correlation between ice adhesion strength and Young modulus was also investigated. The best‐performing matrix in terms of mechanical properties and weathering resistance had its surface energy characteristics altered—via two fluorinated silicone additives at various concentrations—to lower ice adhesion strength. For the steel substrates, the optimized additive‐altered surface showed a lower ice adhesion strength (decreasing from 362 to 94 kPa) with an adhesion reduction factor of 10.6. The fabricated coatings can serve as a protective layer for marine harbor infrastructures.
The effects ofCOVID‐19 on information management in remote and hybrid work environments
Authors: Nakash Maayan , Bouhnik Dan 
Published: June 2023

AbstractThis empirical research examines the effects of the COVID‐19 pandemic on information management (IM) in remote or hybrid work. We present an in‐depth statistical analysis of 716 responses to questionnaires received from employees and managers of four Israeli government ministries. The participants were asked to report characteristics such as accessibility, retrieval speed, ease of locating, and relevance of information, in order to assess the quality of organizational IM before and during COVID‐19. The findings reveal that IM quality was maintained even when organizations were forced to quickly adapt to working remotely during the pandemic. Regardless of work location, differences in perception of IM were found among organizations of different sizes: large, medium, and small. The majority of respondents who reported not using IM systems (IMS) before COVID‐19 also stated that even after the pandemic's onset, they still did not use them. A lower frequency of IMS use has been associated with a decline in IM quality. Given the far‐reaching changes in IM induced by the pandemic, many of which have the potential to be long‐lasting, these findings serve as an opening for valuable future research.
LABS: Laboratory Automation and Batch Scheduling – A Modular Open Source Python Program for the Control of Automated Electrochemical Synthesis with a Web Interface
Authors: Hielscher Maximilian M. , Dörr Maurice , Schneider Johannes , Waldvogel Siegfried R. 
Published: June 2023

AbstractWith LABS, an open source Python‐based lab software is established that enables users to orchestrate automated synthesis setups. The software consists of a user‐friendly interface for data input and system monitoring. A flexible backend architecture enables the integration of multiple lab devices. The software allows users to easily modify experimental parameters or routines and switch between different lab devices. Compared to previously published projects, we aim to provide a more widely applicable and easily customizable automation software for any experimental setup. The usefulness of this tool was demonstrated in the oxidative coupling of 2,4‐dimethyl‐phenol to the corresponding 2,2’‐biphenol. In this context, the suitable electrolysis parameters for flow electrolysis were optimized by way of design of experiments.
Considerations for practitioners using applied behavior analysis therapy with autistic deaf/hard of hearing clients
Authors: Edmier Kathleen , Kazee Amanda , Yosick Rachel 
Published: June 2023

AbstractThere is scarce research on adapting evidence‐based practices, such as Applied Behavior Analysis (ABA)‐based therapy, for Deaf/Hard of Hearing (DHH) children diagnosed with autism spectrum disorder (ASD). The current case involved delivering intensive ABA‐based intervention for improving communication skills to a 5‐year‐old child, Lilly, with dual diagnoses of DHH and ASD. Teaching procedures were modified to include consideration of deaf cultural norms, incorporation of American Sign Language (ASL)‐specific instructional procedures, and consultation with an ASL interpreter within all intervention sessions. Outcome data measured by the Verbal Behavior Milestones Assessment and Placement Program (VB‐MAPP) reflected rapid skill acquisition across multiple verbal operants within a 7‐month admission. Recommendations on how to deliver intensive ABA‐based intervention services to children with dual diagnoses of DHH and ASD are provided for further research and discussion. Utilizing modified behavior analytic procedures can provide increased access to needed services for this population.
Towards sustainability: An environmental strategy choice, environmental performance, and the moderating role of stakeholder pressure
Authors: Seroka‐Stolka Oksana 
Published: June 2023

AbstractNowadays, many companies face to adopt environmental strategies (ESs) that improve performance and fulfill the requirements of stakeholders. The aim of this study is to investigate the relationship between the choice of ES and environmental performance (EP) and also to examine the moderating effect of stakeholder pressure (SP) on this relationship. Additionally, it tests the direct impact of SP on EP. The linear regression model is used to analyze these tested interactions. Although the effect of the environmental strategic choice on EP has been investigated by scholars, the moderating impact of SP on this relation has scarcely been explored. Furthermore, the previous research studies on the linkage between SP and EP has provided mix results. The results of the study show that there is a significant and positive influence of the choice of ES on EP. The empirical examination indicates that enterprises, which adopt proactive ESs, obtain increased EP than companies with reactive ESs. The research also confirms the direct and positive influence of SP on EP. However, the results from Hayes' PROCESS technique do not confirm a statistically significant effect of SP moderation on the relationship between the choice of ES and EP.
Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Authors: Cartmel Brenda , Li Fang‐yong , Zhou Yang , Gottlieb Linda , Lu Lingeng , Mszar Reed , Harrigan Maura , Ligibel Jennifer A. , Gogoi Radhika , Schwartz Peter E. , Risch Harvey A. , Irwin Melinda L. 
Published: June 2023

AbstractBackgroundIn randomized trials in women with breast cancer, exercise has been shown to have beneficial effects on cancer‐related circulating biomarkers that may impact survival. Such studies are lacking for ovarian cancer.MethodsThis secondary analysis of a published randomized controlled trial examined the impact of a 6‐month exercise intervention versus attention‐control on change in prespecified circulating biomarkers (cancer antigen 125 (CA‐125), C‐reactive protein (CRP), insulin‐like growth factor‐1(IGF‐1), insulin and leptin) in a subset of participants who provided a fasting blood draw (N = 104/144) at enrollment and at 6 months. Change in biomarkers between study arms was compared using a linear mixed effects model analysis. An exploratory analysis of the exercise intervention versus attention‐control on all‐cause mortality included all (N = 144) participants. All statistical tests were two‐sided.ResultsParticipants included in the biomarker analysis were 57.0 ± 8.8 (mean ± SD) years old and 1.6 ± 0.9 years post‐diagnosis. Adherence to the exercise intervention was 176.4 ± 63.5 min/week. Post intervention IGF‐1 (group difference in change: −14.2 (−26.1 to −2.3) ng/mL (least squared means (95% CI))) and leptin (−8.9 (−16.5 to −1.4) ng/mL) were significantly reduced in the exercise group (N = 53) compared to those in attention‐control (N = 51). No group difference in change was seen for CA‐125 (p = 0.54), CRP (p = 0.95), or insulin (p = 0.37). With median follow‐up of 70 months [range 6.6–105.4 months], 50/144 (34.7%) (exercise group; 24/74 (32.4%) versus attention‐control group; 26/70 (37.1%)) participants died with no between group difference in overall survival (p = 0.99).ConclusionsFurther studies are needed to determine the clinical significance of exercise‐induced changes in cancer‐related circulating biomarkers in women with ovarian cancer.
Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition
Authors: Clasen Joanna L. , Mabunda Rita , Heath Alicia K. , Kaaks Rudolf , Katzke Verena , Schulze Matthias B. , Birukov Anna , Tagliabue Giovanna , Chiodini Paolo , Tumino Rosario , Milani Lorenzo , Braaten Tonje , Gram Inger , Lukic Marko , Luján‐Barroso Leila , Rodriguez‐Barranco Miguel , Chirlaque María‐Dolores , Ardanaz Eva , Amiano Pilar , Manjer Jonas , Huss Linnea , Ljungberg Börje , Travis Ruth , Smith‐Byrne Karl , Gunter Marc , Johansson Matthias , Rinaldi Sabina , Weiderpass Elisabete , Riboli Elio , Cross Amanda J. , Muller David C. 
Published: June 2023

AbstractBackgroundRenal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology.Materials & MethodsWe investigated associations of age at menarche and age at menopause, pregnancy‐related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.ResultsDuring 15 years of follow‐up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and women who were older at age of first pregnancy had lower rates of RCC (30 years + vs. <20 years HR = 0.53, 95% CI 0.34, 0.82). Additionally, we identified a positive association for hysterectomy (HR = 1.43 95% CI 1.09, 1.86) and bilateral ovariectomy (HR = 1.67, 95% CI 1.13, 2.47), but not unilateral ovariectomy (HR = 0.99, 95% CI 0.61, 1.62) with RCC risk. No clear associations were found for age at menarche, age at menopause or exogenous hormone use.ConclusionOur results suggest that parity and reproductive organ surgeries may play a role in RCC aetiology.
Three Undescribed Flavonoids and Amide from Abrus mollis Hance with Hepatoprotective Effects
Authors: Du Kaicheng , Li Xingyao , Zheng Changwei , Ju Yan , Meng Dali 
Published: June 2023

AbstractThrough a phytochemical investigation of Abrus mollis Hance, a folk medicinal plant in China, we isolated and identified three undescribed compounds, including two flavonoids and one amides alkaloid, along with nine known from this plant. Their structures were elucidated by analyses of 1D, 2D NMR, HR‐ESI‐MS, ECD, and DP4+ analysis. Furthermore, we evaluated the hepatoprotective effects of all twelve compounds on D‐GalN‐induced Brl‐3 A cells. According to the results, at a concentration of 25 μM, the cell survival rates were observed to be 71.92±0.34 %, 70.03±1.29 %, and 69.11±1.90 % for compound 2, 4, and 11, respectively. Further experimental studies showed that compound 2 (EC50 5.76±0.37 μM) showed more significant protective activity than the bicyclol.