bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early pain in females is linked to late pathological features in murine experimental osteoarthritis
Authors: Valdrighi Natália , Blom Arjen B. , van Beuningen Henk M. , Vitters Elly L. , Helsen Monique M. , Walgreen Birgitte , van Lent Peter L.E.M. , Koenders Marije I. , van der Kraan Peter M. , van de Loo Fons A.J. , Blaney Davidson Esmeralda N. 
Published: June 2023

Background
Osteoarthritis (OA) is a progressive joint disease and a major cause of chronic pain in adults. The prevalence of OA is higher in female patients, who tend to have worse OA outcomes, partially due to pain. The association between joint pain and OA pathology is often inconclusive. Preclinical research studies have largely overlooked sex as a potential determinant in joint pain during OA. This study aimed to investigate the role of sex in joint pain in the collagenase-induced OA (CiOA) model and its link with joint pathology.

Methods
Multiple aspects of pain were evaluated during identically executed experiments of CiOA in male and female C57BL/6J mice. Cartilage damage, osteophyte formation, synovial thickness, and cellularity were assessed by histology on day 56. The association between pain and pathology was investigated, disaggregated by sex.

Results
Differences in pain behavior between sexes were found in the majority of the evaluated pain methods. Females displayed lower weight bearing ability in the affected leg compared to males during the early phase of the disease, however, the pathology at the end stage was comparable between sexes. In the second cohort, males displayed increased mechanical sensitivity in the affected joint compared to females but also showed more cartilage damage at the end stage of the model. Within this cohort, gait analysis showed varied results. Males used the affected paw less often and displayed dynamic weight-bearing compensation in the early phase of the model. These differences were not observed in females. Other evaluated parameters displayed comparable gait behavior between males and females. A detailed analysis of individual mice revealed that seven out of 10 pain measurements highly correlated with OA histopathology in females (Pearson r range: 0.642–0.934), whereas in males this measurement was only two (Pearson r range: 0.645–0.748).

Conclusion
Our data show that sex is a determinant in the link between pain-related behavior with OA features. Therefore, to accurately interpret pain data it is crucial to segregate data analysis by sex to draw the correct mechanistic conclusion.
A Study on People's Participation in the Conservation of Rural Tanks for Sustainable Rural Development in Cuddalore District, Tamil Nadu, India
Authors: Balamurugan P. 
Published: June 2023

The participation of people in any task of the activity shows the perfect and fulfills the requirements of society in general and individual in specific. The sustainable development in rural area requires the natural resources conservation with the effective people’s participation for the sustainable utilization without damage. At this juncture, rural tanks play a very crucial role in the process of sustainable development in its command area. Many numbers of tank institution are functioning for each tank system to resolve the issues related to maintenance of rural tanks and water sharing disputes between the head reach and tail-end users. Less people’s participation and lack of attention of water users of the rural tanks shown that the rural tank systems have been reduced and retrenched, which resulted in decreasing the total crop land under cultivation and reduction in the benefits available. Some of the rural tanks have been destroyed and urbanised due to intensity of population and enhancement of modern marketing. All these endangered issues are due to lack of people’s participation and prolonged misuse and severe encroachment. They are caused to push and create the problem of water scarcity and resources logging.
Based on the background stated above, an attempt has been made to analyse the conservation of rural tanks for sustainable rural development through effective people’s participation.
A Study on Consumer Buying Behaviour of Insecticide in Prayagraj Uttar Pradesh
Authors: Shukla Akash , Barker Nitin , Sunil Kale Pranil 
Published: June 2023

Insecticides are the substances which are used to kill insects. They have the potential to alter ecosystem components majorly and are toxic to animals as well as humans. Some insecticides become concentrated as they spread in the food chain. Insecticides are insecticides that are formulated to kill, harm, repel or mitigate one or more species of insect. Insecticides work in different ways. Some insecticides disrupt the nervous system, whereas others may damage their exoskeletons, repel them or control them by some other means. They can also be packaged in forms including sprays, dusts, gels, and baits.
It has been revealed during the study that there is availability factor which are affecting buying behaviour of TAKAF by different categories of respondents are availability at wholesaler shop (29.16%), availability at retailer shop (58.33%) and availability on online platform (12.50%) respectively. It has been revealed during the study that there is quality factor which are affecting buying behaviour of TAKAF by different categories of respondents are preventive (33,33%), curative (37.50%) and Safe to applicator (29.16%) respectively. It has been found during the study that the major constraint in marketing of TAKAF was the high cost of transportation with 30 respondents response ranked I, followed by shortage of trading ranked II, followed by Price fluctuation with 18 respondents response ranked III, followed by High cost storage with 16 respondents response ranked IV, followed by High prices with 15 respondent response ranked V, followed by storage with 14 respondents response ranked VI and lastly delayed sales with 6 respondent response ranked VII.
Effects of Pretilachor Pyribenzoxim Pollution on the Water Quality, Serum Biochemical Indices, and Behavioural Response of Oreochromis niloticus Juveniles
Authors: Adene Ibidun Comfort 
Published: June 2023

Aims: The effects of Pretilachor pyribenzoxim (PP) pollution on the water quality, serum biochemical indices, and behavioural response of Oreochromis niloticus Juveniles were studied.
Study Design: The completely randomized design was used in this study.
Place and Duration of Study: The experiment was carried out in the Central Laboratory of the Fisheries and Aquaculture Department, Faculty of Agriculture, Adekunle Ajasin University Akungba-Akoko, Nigeria, between January and March 2023.
Methodology: The experiment was carried out in 30 L of non-chlorinated and aerated water in rectangular plastic tanks (45cm x 30cm x 30cm). 250 juveniles O. niloticus of both sexes were collected from Federal University of Technology, Akure, Ondo state and acclimatized for 14days in the laboratory. During rearing period, the fish were fed coppen feed at 2% body weight. In a definitive test, a group of 10 fish specimen (11.3-17.5cm length and 10.5-32.3g weight) were treated at random to nominal PP doses of 0.0, 0.10, 0.125, 0.150, 0.175, and 0.2 ml being diluted in 30 litres of water and labelled T1. T2, T3, T4, T5 and T6, respectively in triplicate. The LC50 of PP, test water's physicochemical, behavioural responses and serum biochemical indices were determined.
Results: The dissolved oxygen depleted (P<0.05) in T5 and T6, compared to T1 and the rest of the treatments. The water conductivity increases (P<0.05) with an increased concentration of PP contamination. The water's total dissolved solids levels increased progressively with an increase in PP concentration. The total dissolved solids in T5 and T6 were similar (P>0.05) to T4 but lower (P<0.05) than T1 and T2. Juveniles in treatments 2, 3, 4, 5 and 6 shows behavioural responses such as loss of reflex, fin deformation, erratic swimming, air gulping, and moulting. The serum total protein of the juveniles in treatments 2, 3, 4, 5 and 6 was lower (P<0.05) than T1. Serum creatinine level increased with increased PP contamination from treatments 1 to 6. The serum aspartate aminotransferase (AST) of the juvenile in T3, T4, T5 and T6 were higher (P<0.05) than in T1. The serum Alanine aminotransferase (ALT) of the juvenile in T2, T3, T4, T5 and T6 were significantly (P<0.05) higher than T1.
Conclusion: The exposure of juvenile O.niloticus to PP contamination affected the physicochemical properties of water, behaviour and Serum biochemicals of juvenile O. niloticus fish. Hence, leaching of pp into water bodies through Agricultural activities should be mornitored to reduce lost of fish which can lead to economic detune.
Evaluation of Antidiabetic Effect of Crude Aqueous Extract of Nut, Leaf and Stem Parts of Vigna subterranae on Streptozotocin-Induced Diabetic Rats
Authors: Abigail Adugbe , Godwin Vongdip Nanman , Uduakobong Obot Blessing , Luka Carol D. 
Published: June 2023

Diabetes is a metabolic disorder characterized by abnormally high blood glucose level. One of the plants frequently used to manage diabetes is Vigna subterrenea, also known as the Bambaranut. The aim of this study is to verify the usefulness of this plant to mitigate the effects of diabetes. Thirty (30) Wistar rats weighing 170-200 g were used for this evaluation, the rats were randomly divided into six groups namely; group A: normal control, group B: diabetic control, group C: metformin (500 mg), group D: leaf extract (1000 mg), group E: stem extract (1000 mg), and group F: nut extract (1000 mg). Alkaloids, flavonoids, saponins, balsam carbohydrate, phenol, steroids, and cardiac glycosides were all identified during the phytochemical screening of aqueous extracts. Intraperitoneal injections were used to cause diabetes using streptozotocin across groups and treatment commenced after 48 hours of induction upon confirmation of diabetes mellitus. The sacrifices of animals occurred after a 28-day session of treatment. For hematological and biochemical examination, blood, liver, kidney, and pancreas were obtained. Significantly lowering of fasting blood sugar in the extract treatment groups resulted in improved biochemical markers (P≤0.05). Serum enzyme markers showed a significant drop (P≤0.05) while High Density Lipoprotein (HDL) level increased considerably when compared with diabetic control. Also, when compared to the diabetic control group, the markers of kidney function all noticeably dropped, while electrolyte levels rose. Additionally, there was a significant positive impact on hematological parameters. In accordance with the results of this investigation, V subterrenea is a potent hypoglycemia and hypolipidemic agent on streptozotocin-induced diabetic rats.
Resolution of aortic regurgitation due to Venturi effect after device closure of ruptured sinus of Valsalva aneurysm
Authors: Kumar Dhiraj , Kesavan Vishnu , Lanjewar Charan P. , Sabnis Girish 
Published: June 2023

AbstractWe describe a case of a ruptured sinus of Valsalva with severe aortic regurgitation treated by transcatheter device closure. The regurgitation was purely due to leaflet entrapment because of the hemodynamic Venturi effect which was effectively treated.
Bulk-boundary thermodynamic equivalence: a topology viewpoint
Authors: Zhang Ming , Jiang Jie 
Published: June 2023

Abstract
Setting the cosmological constant to be dynamical, we study the bulk and boundary thermodynamics of charged Anti-de Sitter black holes. We develop mass/energy formulas in terms of thermodynamic state functions for the extended thermodynamics, mixed thermodynamics, and boundary conformal field theory thermodynamics. We employ the residue method to study the topological properties of the phase transitions. Our analysis reveals that the bulk and boundary thermodynamics are topologically equivalent for both criticalities and first-order phase transitions in the canonical ensembles, as well as for the Hawking-Page(-like) phase transitions in the grand canonical ensembles. Additionally, those three kinds of phase transitions are shown to be distinguished by their unique topological charges. Our results exemplify the gravity-gauge duality in terms of topology.
Asymptotic dynamics of three dimensional supergravity and higher spin gravity revisited
Authors: Merbis Wout , Neogi Turmoli , Ranjbar Arash 
Published: June 2023

Abstract
We reconsider the Hamiltonian reduction of the action for three dimensional AdS supergravity and W3 higher spin AdS gravity in the Chern-Simons formulation under asymptotically anti-de Sitter boundary conditions. We show that the reduction gives two copies of chiral bosons on the boundary. In particular, we take into account the holonomy of the Chern-Simons connection which manifests itself as zero mode of the momentum of the boundary chiral boson. We provide an equivalent formulation of the boundary action which we claim to be the geometric action on symplectic leaves of a (super-)Virasoro or a higher spin WN Poisson manifold in the case of supergravity or higher spin gravity respectively, where the intersection of leaves (given in terms of leaves representatives) can be identified as the bulk holonomy. This concludes the extension to non-linear algebras where the notion of coadjoint representation is not well-defined. The boundary Hamiltonian depends on a choice of boundary conditions and is equivalent to the Schwarzian action for corresponding Brown-Henneaux boundary conditions. We make this connection explicit in the extended supersymmetric case. Moreover, we discuss the geometric action in the case of W3 AdS3 gravity in both $$ \mathfrak{sl} $$
sl
(3) highest weight representations based on principal and diagonal $$ \mathfrak{sl} $$
sl
(2) embeddings.
Positivity bounds on Higgs-Portal dark matter
Authors: Kim Seong-Sik , Lee Hyun Min , Yamashita Kimiko 
Published: June 2023

Abstract
We consider the positivity bounds for WIMP scalar dark matter with effective Higgs-portal couplings up to dimension-8 operators. Taking the superposed states for Standard Model Higgs and scalar dark matter, we show that the part of the parameter space for the effective couplings, otherwise unconstrained by phenomenological bounds, is ruled out by the positivity bounds on the dimension-8 derivative operators. We find that dark matter relic density, direct and indirect detection and LHC constraints are complementary to the positivity bounds in constraining the effective Higgs-portal couplings. In the effective theory obtained from massive graviton or radion, there appears a correlation between dimension-8 operators and other effective Higgs-portal couplings for which the strong constraint from direct detection can be evaded. Nailing down the parameter space mainly by relic density, direct detection and positivity bounds, we find that there are observable cosmic ray signals coming from the dark matter annihilations into a pair of Higgs bosons, WW or ZZ.
Quantum Kerr-de Sitter black holes in three dimensions
Authors: Panella Emanuele , Svesko Andrew 
Published: June 2023

Abstract
We use braneworld holography to construct a three-dimensional quantum-corrected Kerr-de Sitter black hole, exactly accounting for semi-classical backreaction effects due to a holographic conformal field theory. By contrast, classically there are no de Sitter black holes in three-dimensions, only geometries with a single cosmological horizon. The quantum Kerr black hole shares many qualitative features with the classical four-dimensional Kerr-de Sitter solution. Of note, backreaction induces inner and outer black hole horizons which hide a ring singularity. Moreover, the quantum-corrected geometry has extremal, Nariai, and ultracold limits, which appear as fibered products of a circle and two-dimensional anti-de Sitter, de Sitter, and Minkowski space, respectively. The thermodynamics of the classical bulk black hole, described by the rotating four-dimensional anti-de Sitter C-metric, has an interpretation on the brane as thermodynamics of the quantum black hole, obeying a semi-classical first law where the Bekenstein-Hawking area entropy is replaced by the generalized entropy. For purposes of comparison, we derive the renormalized quantum stress-tensor due to a free conformally coupled scalar field in the classical Kerr-de Sitter conical geometry and perturbatively solve for its backreaction.
Asymptotic accelerated expansion in string theory and the Swampland
Authors: Calderón-Infante José , Ruiz Ignacio , Valenzuela Irene 
Published: June 2023

Abstract
We study whether the universal runaway behaviour of stringy scalar potentials towards infinite field distance limits can produce an accelerated expanding cosmology à la quintessence. We identify a loophole to some proposed bounds that forbid such asymptotic (at parametric control) accelerated expansion in 4d $$ \mathcal{N} $$
N
= 1 supergravities, by considering several terms of the potential competing asymptotically. We then analyse concrete string theory examples coming from F-theory flux compactifications on Calabi-Yau fourfolds, extending previous results by going beyond weak string coupling to different infinite distance limits in the complex structure moduli space. We find some potential candidates to yield asymptotic accelerated expansion with a flux potential satisfying $$ \gamma =\frac{\left\Vert \nabla V\right\Vert }{V}<\sqrt{2} $$
γ
=

‖
∇
V
‖

V

<

2

along its gradient flow. However, whether this truly describes an accelerated expanding cosmology remains as an open question until full moduli stabilization including the Kahler moduli is studied. Finally, we also reformulate the condition for forbidding asymptotic accelerated expansion as a convex hull de Sitter conjecture which resembles a convex hull scalar WGC for the membranes generating the flux potential. This provides a pictorial way to quickly determine the asymptotic gradient flow trajectory in multi-moduli setups and the value of γ along it.
Akzidentelle vs. vorgetäuschte Kettensägenverletzung am Unterschenkel
Authors: Ackermann Ines , Müller Anna , Baisch Severine , Kunz Sebastian Nico 
Published: June 2023

ZusammenfassungAkzidentelle Verletzungen mit einer Kettensäge betreffen oftmals den Oberschenkel, den Kopf und die Finger. Verletzungen des Unterschenkels sind vergleichsweise seltener. Im Rahmen einer rechtsmedizinischen Beurteilung derartiger Vorfälle ist neben der unmittelbaren, tatsächlichen Verletzungsbeurteilung v. a. die Rekonstruktion des Tathergangs essenziell. Es gilt hier, besonders die Vortäuschung eines Unfalls und somit eine Selbstbeibringung auszuschließen bzw. zu bestätigen.Ausgehend von einem Fallbeispiel werden in der vorliegenden Arbeit die rechtsmedizinischen und wundmorphologischen Aspekte von Verletzungen mit einer Kettensäge analysiert und im Rahmen von experimentellen Vergleichsversuchen mit dem Verletzungsbild durch ein Messer und eine Glasscherbe verglichen.Mit einer Stihl-MSA-160C-Motorsäge wurden an einer Schweinekeule mehrere Schnitte gesetzt und diese hinsichtlich ihrer Morphologie Vergleichsschnitten eines Küchenmessers und einer Glasscherbe gegenübergestellt.Anhand spezifischer Wundmerkmale, der Schnittführung sowie der Überwindung des Sicherheitsschalters bei entsprechender Griffhaltung der Säge konnte im aktuellen Fall die Verletzung zweifelsfrei einem Unfallgeschehen zugeordnet werden.
Pathological findings associated with Dipetalonema spp. (Spirurida, Onchocercidae) infection in two species of Neotropical monkeys from Brazil
Authors: Ehlers Luiza Presser , Slaviero Mônica , De Lorenzo Cíntia , Fagundes-Moreira Renata , de Souza Viviane Kelin , Perles Lívia , Baggio-Souza Vinicius , Bezerra-Santos Marcos Antonio , Modrý David , Benovics Michal , Panziera Welden , Driemeier David , Pavarini Saulo Petinatti , Soares João Fabio , Otranto Domenico , Sonne Luciana 
Published: June 2023

AbstractAmong vector-borne helminths, filarioids of the genus Dipetalonema (Spirurida: Onchocercidae) localize in several tissues and body cavities of several animal species, causing mild to moderate lesions. The pathological findings associated with Dipetalonema spp. infection in Neotropical monkeys from southern Brazil are herein described, along with a fatal case due to filarial polyserositis and entrapment of an intestinal segment. At necropsy, nematodes were observed in abdominal and thoracic cavities, or in the pericardium of 37 (31.3%) out of the 118 individuals examined (i.e., 35 Alouatta guariba clamitans and two Sapajus nigritus). In addition, at histology, 27.0% of positive animals presented microfilarie (inside blood vessels of lung, spleen, liver, and brain) and 8.1% presented adult nematodes in the heart, lung, and liver. In two cases, cross-sections of filarioids were associated with areas of epicardial thickening with intense fibrosis and pyogranulomatous inflammation in the brain, heart, liver, lungs, or spleen. The DNA fragment was amplify using the cox1 gene, sequenced and analyzed to identify the nematode species collected; presence of Wolbachia was assessed in the filarioids using the 16S rRNA gene. At BLAST analysis of the cox1 gene, 10 sequences showed 91.7% nucleotide identity with Dipetalonema gracile, and two with D. gracile (98.5%) and Dipetalonema graciliformis (98.3%). Phylogenetic analyses clustered sequences of the cox1 obtained in this study in two clades corresponding with the host species. Wolbachia sp. endosymbiont was detected in four samples. Data herein reported provide a description of pathological lesions associated with the infection by Dipetalonema spp., suggesting that they may cause disease in Neotropical monkeys. In addition, a better understanding of diversity and biology of Dipetalonema spp. in South America is needed to assess the impact they may cause in native non-human primates from Brazil.
Dysphagia Prevalence and Outcomes Associated with the Evolution of COVID-19 and Its Variants in Critically Ill Patients
Authors: Clayton Nicola A. , Freeman-Sanderson Amy , Walker Elizabeth 
Published: June 2023

AbstractData collected during the 2020–21 COVID-19 alpha wave indicated dysphagia prevalence rates up to 93%. Whilst many patients recovered during hospital admission, some experienced persistent dysphagia with protracted recovery. To explore (1) prevalence, (2) treatment, and (3) recovery patterns and outcomes for swallowing, in the ICU patient with Delta and subsequent variants of COVID-19. Prospective observational study. Patients admitted to 26 Intensive Care Units (ICUs) over 12 months, diagnosed with COVID-19, treated for survival and seen by Speech–Language Pathology (SLP) for clinical swallowing assessment were included. Demographic, medical, SLP treatment, and swallowing outcome data were collected. 235 participants (63% male, median age = 58 years) were recruited. Median mechanical ventilation was 16 days, and ICU and hospital length of stay (LOS) were 20 and 42 days, respectively. ICU-Acquired Weakness (54%) and delirium (49%) were frequently observed. Prevalence of dysphagia was 94% with the majority (45%) exhibiting profound dysphagia (Functional Oral Intake Scale = 1) at initial assessment. Median duration to initiate oral feeding was 19 days (IQR = 11-44 days) from ICU admission, and 24% received dysphagia rehabilitation. Dysphagia recovery by hospital discharge was observed in 71% (median duration = 30 days [IQR = 17-56 days]). Positive linear associations were identified between duration of intubation, mechanical ventilation, hospital and ICU LOS, and duration to SLP assessment (p = 0.000), dysphagia severity (p = 0.000), commencing oral intake (p = 0.000), dysphagia recovery (p < 0.01), and enteral feeding (p = 0.000). Whilst older participants had more severe dysphagia (p = 0.028), younger participants took longer to commence oral feeding (p = 0.047). Dysphagia remains highly prevalent in ICU COVID-19 patients. Whilst invasive ventilation duration is associated with swallowing outcomes, more evidence on dysphagia pathophysiology is required to guide rehabilitation.