bluuebunny/crossref_metadata_2025_split huggingface dataset:
The benefits of adjuvant chemotherapy for upper tract urothelial carcinoma require at least three cycles
Authors: Yumioka Tetsuya , Morizane Shuichi , Muraoka Kuniyasu , Oono Hirofumi , Isoyama Tadahiro , Sakaridani Naoyuki , Ono Koji , Sejima Takehiro , Kadowaki Hiroyuki , Hikita Katsuya , Honda Masashi , Takenaka Atsushi 
Published: June 2023

Abstract
Background
Upper urinary tract urothelial carcinoma (UTUC) is uncommon. In advanced cases, radical nephroureterectomy (RNU) alone is not curative, and recurrence and metastasis are likely to occur. Adjuvant chemotherapy (AC) is an evidence-based treatment. However, the optimal number of AC cycles is not clear. This multicenter study investigated the number of cycles required for the beneficial effects of AC in Japanese patients with UTUC.
Methods
Patients who were diagnosed with UTUC and underwent RNU at our hospital and affiliated hospitals from January 2010 to September 2020 were included in the study. Patients with pathological T3 or higher or lymph node metastasis were observed or given AC, and their responses were compared. The AC regimens included gemcitabine and cisplatin or gemcitabine and carboplatin. Patients were classified into three groups: the observation group, the two cycles of AC group, and the three to four cycles of AC group. Patients were also classified into two groups: the observation and two cycles of AC group and the three to four cycles of AC group. The survival curves for recurrence-free survival (RFS) and cancer-specific survival (CSS) were evaluated using Kaplan–Meier analyses.
Results
Of the 133 patients enrolled in the study, 24 received 2 cycles of AC, 37 received 3–4 cycles, and 72 were observed only. The median RFS for all patients was 3.58 years, and the median CSS for all patients was 4.77 years. The 5-year RFS was 67.1% for the 3–4 cycles of AC group and 41.7% for the observation and two cycles of AC group. The 5-year CSS was 72.2% for the 3–4 cycles of AC group and 35.9% for the observation and two cycles of AC group. RFS and CSS were significantly longer in the three to four cycles of AC group compared to the observation and 2 cycles group (P = 0.048 and P = 0.005 respectively).
Conclusion
AC prolonged RFS and CSS in the real-world setting. However, at least three cycles of AC are required to achieve beneficial effects in patients with UTUC.
Optimized Schwarz Domain Decomposition Algorithms for the Closest Point Method on Closed Manifolds
Authors: Yazdani Alireza , Haynes Ronald D. , Ruuth Steven J. 
Published: June 2023

Abstract
The closest point method (CPM) is an embedding method that represents surfaces using a function that maps points in a neighbourhood of the surface to their closest points on the surface. This mapping brings intrinsic data onto the embedding space, allowing us to numerically approximate surface intrinsic partial differential equations by standard numerical methods in a tubular neighbourhood of the surface. Solving the surface positive Helmholtz equation by the CPM paired with finite differences yields a large, sparse, and non-symmetric linear system. Here Schwarz domain decomposition methods (DDMs) provide partitioned, parallel algorithms to solve these linear systems. We theoretically investigate the convergence of optimized Schwarz-CPM methods for 1-manifolds in Rd. The analysis is followed by numerical experiments for verification.
AMS Classification: 65N25 , 65N55
DFT calculations for Adsorption of H2S and other natural gas compounds on M-BTC MOF clusters
Authors: Braga Mateus U. C. , Perin Gabriel H. , Oliveira Leonardo H. , Arroyo Pedro A. 
Published: June 2023

Abstract
Desulfurization is a necessary process to reduce the corrosiveness of natural gas. In this regard, H2S adsorption on porous materials is the focus of study for development of new eco-friendly technologies. Although there are many experimental and theoretical studies about gas adsorption on MOFs, so far, there has been no theoretical work about desulfurization of natural gas or biogas through H2S adsorption on MOF BTC. Therefore, the objective of this study is to preselect which metal center, M2+ = Co2+, Ni2+, Cu2+, or Zn2+, has the highest potential for selective desulfurization of natural gas. DFT calculations were performed at B3LYP‑D3/6‑311++G(2d,p)+LanL2DZ level for H2O, H2S, COS, CO2, and CH4 adsorption on M-BTC MOF clusters in order to obtain equilibrium geometries of adsorption complex, adsorption energies and thermodynamic properties. It was found that Zn-BTC MOF cluster has the highest potential for selective H2S removal from dry natural gas streams, as it has an adsorption energy of ‑79.4 kJ mol‑1, which is 2.4 times higher than CH4. Furthermore, it is an exothermic and thermodynamically favorable process. Through NBO and EDA analyses, it was found that d electrons transfer from adsorbate to unoccupied orbitals of metal center contributes mainly to H2S chemisorption on Zn-BTC and Co-BTC, while for CO2 and CH4 adsorption, non-bonded interactions predominate. Most of the gases coordinate to coordinatively unsaturated site of BTC MOF cluster at axial position, indicating a stronger interaction with metal center compared to linkers.
YY1-induced lncRNA00511 promotes melanoma progression via the miR-150- 5p/ADAM19 axis
Authors: Chen yani , Fu Xinrui , Guo Hua , Fu Xinyao , Shi Kesong , Gao Tian , Yu Haiquan 
Published: June 2023

Abstract

Background
Long noncoding RNAs (lncRNAs) are key regulators of oncogenic processes, and one such lncRNA is lncRNA511 (LINC00511), which is associated with breast, stomach, lung, and colorectal cancers. However, its specific involvement in melanoma remains unclear. Here, we aimed to investigate the expression and functional role of LINC00511 in melanoma.
Methods
We examined the expression of LINC00511 in melanoma cell lines (A375 and SK-Mel-28) and melanoma tissues obtained from patients. We conducted knockdown experiments to assess the effects of LINC00511 on melanoma cell migration, invasion, and tumor growth in vivo. To investigate LINC00511 transcription regulators, we performed chromatin immunoprecipitation assays. Additionally, we analyzed the subcellular localization of LINC00511 and confirmed that its interaction with microRNA-150-5p (miR-150-5p) by RNA immunoprecipitation assay (RIP), miRNA pull-down and luciferase reporter assay. Furthermore, we conducted rescue assays to validate our findings, namely on the LINC00511/miR-150-5p/ADAM19 axis and its impact on the PI3K/AKT pathway.
Results
LINC00511 was found to be highly expressed in melanoma cell lines and patient tissues. Knockdown of LINC00511 resulted in the inhibition of melanoma cell migration, invasion, and subcutaneous tumor growth in vivo. Yin Yang 1 (YY1) was identified as the transcription factor responsible for LINC00511 upregulation. Furthermore, LINC00511 was predominantly localized in the cytoplasm and exhibited direct interaction with miR-150-5p. Knockdown of miR-150-5p rescued the effects of LINC00511 silencing on melanoma cells. Moreover, we identified ADAM19 as a downstream target of miR-150-5p, its overexpression promoted melanoma cell proliferation. Rescue assays confirmed that LINC00511 acted as a competing endogenous RNA, sponging miR-150-5p and increasing ADAM19 expression, culminating in activation of the PI3K/AKT pathway.
Conclusion
This study establishes LINC00511 as an oncogenic lncRNA in melanoma and defines the novel LINC00511/miR-150-5p/ADAM19 axis, which represents a promising therapeutic target for melanoma treatment. Further investigations targeting this axis hold potential for improving outcomes in melanoma patients.
Exposure to hyperoxemia worsens survival and neurological outcome in patients supported by veno-arterial extracorporeal membrane oxygenation: a meta-analysis
Authors: Tigano Stefano , Caruso Alessandro , Liotta Calogero , Via Luigi La , Vargas Maria , Romagnoli Stefano , Giovanni Landoni , Sanfilippo FILIPPO 
Published: June 2023

Abstract

Background Veno-arterial Extracorporeal Membrane Oxygenation (VA-ECMO) is a rescue treatment in refractory cardiogenic shock (CS) or refractory cardiac arrest (CA). Exposure to hyperoxemia is common during VA-ECMO, and its impact on patient’s outcome remains unclear. Methods We conducted a systematic review (PubMed and Scopus) and metanalysis investigating the effects of exposure to hyperoxemia on mortality and poor neurological outcome in patients supported by VA-ECMO. Whenever provided, we used the Odds Ratio (OR) adjusted for confounders. Results are reported as OR and 95% confidence interval (CI). Subgroup analyses were conducted according to VA-ECMO indication and hyperoxemia thresholds. Results Data from 11 observational studies were included. Ten studies reported data on mortality (6 on refractory CA and 4 on CS), and 4 on neurological outcome. Hyperoxemia exposure was associated with higher mortality (OR:1.81, 95%CI [1.22–2.71]; p = 0.003; I2 = 81%) and worse neurological outcome (OR:1.97, 95%CI [1.30–2.96]; p = 0.001; I2 = 0%). Magnitude and effect of these findings remained valid in subgroup analyses conducted according to different hyperoxemia thresholds (> 200 or > 300 mmHg) and VA-ECMO indication, although the association with mortality remained uncertain in the refractory CA population (p = 0.07). Analysis restricted only to studies providing data in adjusted OR confirmed the increased mortality (OR:1.72, 95%CI [1.00-2.97]; p = 0.05) and poorer neurological outcome (OR:1.99, 95%CI [1.18–3.37]; p = 0.01) in patients exposed to hyperoxemia. Conclusions Hyperoxemia exposure after initiation of VA-ECMO is associated with an almost doubled increased probability of poor neurological outcome and mortality. Clinical efforts should be made to avoid severe hyperoxemia during VA-ECMO support.
Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance
Authors: Piska Kamil , Koczurkiewicz-Adamczyk Paulina , Jamrozik Marek , Bucki Adam , Kołaczkowski Marcin , Pękala Elżbieta 
Published: June 2023

Abstract
Purpose
ABC transporters are transmembrane proteins involved in ATP-dependent translocation of organic compounds across cellular membranes. Among them, ABCB1 (P-glycoprotein, MDR1) transporter is one of the most important involved in cancer multi-drug resistance. It also plays a significant role in cancer resistance against anthracyclines, an anticancer group of drugs, including doxorubicin and daunorubicin. Carbonyl reductases and aldo-keto reductases metabolize anthracyclines to carbonyl-reduced, hydroxy metabolites, which have impaired cytotoxic properties. However, metabolites efflux by ABCB1 transporter is not well characterized, while it may be the mechanism responsible for the metabolites' lack of activity.
Methods
In this study recombinant ABCB1 ATPase transporter assay; anthracyclines accumulation assay in resistant cells overexpressing ABCB1; and molecular modeling were used to investigate anthracyclines: doxorubicin and daunorubicin and their carbonyl-reduced metabolites (doxorubicinol, daunorubicinol) susceptibility for ABCB1-dependent efflux.
Results
Based on the kinetics parameters of ATPase activity of ABCB1, it was found that daunorubicinol exerted an exceptionally high potential for being effluxed by the ABCB1 transporter. ABCB1 was found to significantly affect the accumulation pattern of studied chemicals in resistant cancer cells. Doxorubicin and daunorubicin accumulation was influenced by the activity of ABCB1 modulator – valspodar.
Conclusions
Results indicate that ABCB1 activity affects not only anthracyclines but also their metabolites. The effect of ABCB1 on metabolites may be even higher than for parent anthracyclines. Therefore crosstalk between the process of anthracyclines metabolism and metabolites efflux may be the mechanism of impairing anticancer properties of anthracyclines metabolites.
Efficient and green deodorization of sea cucumber peptides by using a low concentration of hydrogen peroxide
Authors: Liu Biying , Su Yongwang , Lv Daofei , Xu Feng , Zhang Yan , Chen Xin , Yuan Wenbing 
Published: June 2023

Abstract
Deodorization of sea cucumber peptides (SCPs) is of great significance due to their potential applications as functional food, anti-fatigue products, skin care products, and cosmetics, etc.; currently, however, there is a lack of a proven way to achieve it. Herein, we develop a safe, green, efficient, and low-cost approach to deodorizing SCPs with a low concentration of medical-grade hydrogen peroxide. The effects of hydrogen peroxide treatment on the deodorization of SCPs including concentration, reaction time, and temperature were studied here. Intensities of the fishy aftertaste of SCPs were rated by sensory evaluation in single-factor and orthogonal experiments. The deodorization experimental conditions were optimized by orthogonal experiments. The experimental results show that the best deodorization conditions of SCPs in the presence of hydrogen peroxide are as follows: the concentration of hydrogen peroxide is 816.2 mmol∙L-1, the deodorization temperature and time is 35°C and 30 min respectively, and the sensory evaluation of the obtained-product is 1.4. And the contents of the total nitrogen and the amino acid nitrogen of these deodorized SCPs are stable. Correspondingly, the moisturizer containing deodorized SCPs is highly stable and has significantly less fishy odor than a moisturizer containing untreated SCPs.
Assembly nanoparticle arrays decorated with ultrathin AAO nanopores for highly sensitive SERS substrate
Authors: Dong Jun , Li Chenlu , Wang Yan , Cao Yi , Fan Yimeng , Han Qingyan , Gao Wei , Wang Yongkai , Qi Jianxia , Sun Mengtao 
Published: June 2023

Abstract
Surface-enhanced Raman scattering (SERS) is widely employed because it offers quick, microscopic, and traceless detection. This study used high-voltage and low-voltage ultrasonic oscillation to embed precious metal nanoparticles into the pores of chemically modified ultra-thin anodic alumina (AAO) films, resulting in a highly sensitive three-dimensional SERS substrate. We improve the substrate's stability and Raman activity by adjusting the particle alloy ratio. For the substrate in this alloy ratio, the Raman signal of probe molecules (Rh6G) adsorbed on the substrate surface is enhanced. the enhancement factor (EF) was as high as 1.40×107, the relative standard deviation (RSD) of 10.6%, and the concentration of Rh6G shows a linear relationship with Raman intensity, with a linear correlation coefficient of 0.961. In addition, we evaluated the substrate's detection effect on thiram molecules, surprisingly, the catalytic effect of the substrate on PATP molecules was discovered during this process. It has been proven that this structure has both good plasmon photocatalytic properties and good practicality and high sensitivity as a Raman enhanced substrate.
Predictive value of the number of metastatic lymph nodes and lymph node ratio on the prognosis of patients with FIGO 2018 stage IIICp cervical cancer: a multi-center retrospective study
Authors: Ye Yanna , Li Zhiqiang , Chen Xiaolin , Huang Yahong , Yao Jilong , Lu Anwei , Lang Jinghe , Liu Ping , Chen Chunlin 
Published: June 2023

Abstract
Purpose
To identify the cut-off values for the number of metastatic lymph nodes (nMLN) and lymph node ratio (LNR) that can predict outcomes in patients with FIGO 2018 IIICp cervical cancer (CC).
Methods
Patients with CC who underwent radical hysterectomy with pelvic lymphadenectomy were identified for a propensity score-matched (PSM) cohort study. A receiver operating characteristic (ROC) curve analysis was performed to determine the critical nMLN and LNR values. Five-year overall survival (OS) and disease-free survival (DFS) rates were compared using the Kaplan–Meier and Cox proportional hazard regression analyses.
Results
This study included 3,135 CC patients with stage FIGO 2018 IIICp from 47 Chinese hospitals between 2004 and 2018. Based on ROC curve analysis, the cut-off values for nMLN and LNR were 3.5 and 0.11, respectively. The final cohort consisted of nMLN ≤ 3 (n = 2,378) and nMLN > 3 (n = 757) groups and LNR ≤ 0.11 (n = 1,748) and LNR > 0.11 (n = 1,387) groups. Significant differences were found in survival between the nMLN ≤ 3 vs. the nMLN > 3 (post-PSM, OS: 76.8% vs. 67.9%, P = 0.003; hazard ratio [HR]: 1.411, 95% confidence interval [CI]: 1.108–1.798, P = 0.005; DFS: 65.5% vs. 55.3%, P < 0.001; HR: 1.428, 95% CI: 1.175–1.735, P < 0.001), and the LNR ≤ 0.11 and LNR > 0.11 (post-PSM, OS: 82.5% vs. 76.9%, P = 0.010; HR: 1.407, 95% CI: 1.103–1.794, P = 0.006; DFS: 72.8% vs. 65.1%, P = 0.002; HRs: 1.347, 95% CI: 1.110–1.633, P = 0.002) groups.
Conclusion
This study found that nMLN > 3 and LNR > 0.11 were associated with poor prognosis in CC patients.
CO2/CH4 glow discharge plasma. Part II: Study of plasma catalysis interaction mechanisms on CeO2
Authors: Garcia-Soto Carolina A. , Baratte Edmond , Silva Tiago , Guerra Vasco , Parvulescu Vasile I. , Guaitella Olivier 
Published: June 2023

Abstract

In situ FTIR transmission experiments for CO2 and CO2-CH4 plasma were performed for a fundamentalstudy of surface plasma interaction with cerium oxide (CeO2) as catalytic surface. Utilizing a DC glow dischargeplasma reactor at low pressure, it was observed that CO2 gas adsorbs in the surface forming tridentatecarbonates and hydrogen carbonates. When CO2-CH4 plasma is ignited, formate species were formed whilecarbonate species disappeared from the surface. The CeO2 pellet has also been placed downstream the plasmain order to observe the role of the gas composition at the exit of CO2-CH4 plasma on CeO2 without any heatingor strong electric field. In addition, the effect of water was investigated in several surface phenomena. OH groups play an important role in the reaction with tridentate carbonates to generate formates under plasma.The gas phase chemistry of the CO2-CH4 plasma used here has been described in details in the part I of this work. The conclusions drawn on the gas phase contribute to the understanding of the observed phenomenaon CeO2. These results enlighten the complex mechanisms occurring during CO2-CH4 plasma reactions onsurfaces that could help in the improvement of CO2 recycling.
Shaping Exciton Dynamics in 2D Semiconductors by Tailored Ultrafast Pulses
Authors: Meron Omri , Arieli Uri , Bahar Eyal , Deb Swarup , Shalom Moshe Ben , Haim Suchowski 
Published: June 2023

Abstract
Excitonic resonances in two-dimensional semiconductors play a crucial role in enhancing nonlinear light-matter interactions. However, the influence of resonant dynamics on the time-dependent behavior of these nonlinear effects has received little attention, as optical wave-mixing is commonly assumed to be instantaneous. In this study, we investigate the impact of excited state dynamics on the generation of second and third-order nonlinearities from Monolayer WSe2 in ambient conditions. By shaping a sub-10fs driving pulse to complement the exciton resonant dynamics, we demonstrate a significant enhancement of four-wave-mixing beyond what is achieved using a transform-limited pulse. Conversely, a time-reversed pulse shape leads to destructive quantum interference effects, suppressing nonlinear generation. We apply this technique simultaneously to two successive exciton states, showcasing the selective choice in the resonant state that produces nonlinearity. The ability to control nonlinear carrier dynamics in two-dimensional semiconductors holds promise for remote noninvasive optical manipulation in optoelectronic devices.
Atlantic Coast water quality in Santa Catarina (Southern Brazil): multivariate analysis and influence of land use and occupation
Authors: Leite Camila Marcon Carvalho , Girardi Rubia , Costa Thiago Guimarães , Sánchez Gerly Mattos , Piazza Gustavo Antonio , Constante Vinicius Tavares 
Published: June 2023

Abstract
This study analyzed data from the quarterly analysis of water quality monitoring in the State of Santa Catarina (Southern Brazil) from the Qualiágua Program. The results of collections carried out in 2019–2021 of 23 analytical parameters in 40 municipalities that comprise the Santa Catarina State coastal slope are presented. The Principal Component Analysis (PCA) technique was applied to the analyzed parameters to verify those that refer to the same sources of contamination and the correlations between them. The data on land use and occupation of the hydrographic basins of each monitoring point were also analyzed complementarily, using data from MonitoraSC. The results showed that the parameters: electrical conductivity, total and dissolved solids and chloride concentration are responsible for most of the data variability, having more influence at monitoring points close to the ocean. On the other hand, nitrate and turbidity are influenced by soil management. Finally, total phosphorus, ammoniacal nitrogen and thermotolerant coliforms had a greater relationship with points that are influenced by urban areas. The PCA analysis was successfully used in establishing these relationships at the points analyzed along the coast in Santa Catarina State. The results obtained will help inspection and decision-making processes related to public policies for water uses in the State and can be used for other locations.
Body measurement changes in adults with pectus excavatum after the Nuss procedure: A study of 272 patients
Authors: Htut Nay , Tzeng I-Shiang , Fan Yu-Jiun , Cheng Yeung-Leung 
Published: June 2023

Abstract
Background
Pectus excavatum is the most common congenital abnormality of the chest wall. Most patients with pectus excavatum have slim bodies. Some studies have been conducted on the physical growth of children and adolescents who underwent the Nuss procedure. This study aimed to evaluate body measurement changes in adult patients with pectus excavatum after the Nuss procedure.
Methods
A total of 272 adult pectus excavatum patients, who underwent the Nuss procedure and pectus bars removal from August 2014 to December 2020, were evaluated retrospectively. Body measurements [body height, body weight (BW), and body mass index (BMI)] of the patients were collected before Nuss repair and after bar removal. Associations between changes in body measurements and clinical and radiological features were evaluated.
Results
BW and BMI were significantly increased after pectus bar removal compared to preoperative parameters (62.3 ± 9.7 kg vs 60.8 ± 8.3 kg, P < 0.01 and 20.4 ± 2.6 vs 20.1 ± 2.4, P = 0.01, respectively). In further analysis, young males (< 30 years, n = 226) or those with more severe deformity (Haller index in CT ≥ 4, n = 104), had a significant improvement in BW and BMI (62.2 ± 8.9 kg vs 60.1 ± 7.1 kg, P < 0.01 and 20.4 ± 2.6 vs 19.9 ± 2.1, P < 0.01; 62.9 ± 9.7 kg vs 60 ± 8.3 kg, P < 0.01 and 20.5 ± 2.6 vs 20 ± 2.4, P < 0.01, respectively) after removal of the bar.
Conclusions
BW and BMI were significantly increased after completing surgical correction of pectus excavatum using the Nuss procedure, in young adult males or patients with more pronounced deformities.