bluuebunny/crossref_metadata_2025_split huggingface dataset:
Andragogia no ensino superior
Authors: Ferreira Tássia Fernandes , Magalhães Junior Antônio Germano , Nóbrega-Therrien Silvia Maria 
Published: December 2022

A Andragogia e seus pressupostos comportam elementos fundamentais ao desenvolvimento do ensino e da aprendizagem de adultos, contemplando questões específicas que requerem atenção por parte dos educadores. Nesse ínterim, no presente artigo objetivou-se compreender a percepção de professores de licenciaturas sobre a importância dos pressupostos andragógicos de Malcolm Knowles. Para isso, partiu-se da seguinte questão: “Os professores de licenciaturas, ainda que possam não saber especificamente o que é Andragogia, percebem como importantes os pressupostos desta?”. Utilizou-se da abordagem de métodos mistos (JOHNSON; ONWUEGBUZIE, 2004), com aplicação de instrumentos de viés quantitativo e elaboração de gráficos, e com análise de cunho qualitativo. Foram sujeitos desta pesquisa 21 professores de nível superior em cursos de licenciaturas, respondentes de um questionário online, dividido em duas seções: questões que abordavam o perfil dos professores; e perguntas sobre a Andragogia e o grau de importância atribuído aos seis pressupostos andragógicos. Conforme análise, verificou-se que os seis pressupostos foram classificados pela maior parte dos 21 professores como importante/muito importante com uma pequena parcela (dois professores, correspondendo a 9,5%) que se utilizou da classificação “pouco importante”. Dessa maneira, considera-se que o questionamento central da pesquisa, supramencionado, foi respondido afirmativamente. À vista dos resultados obtidos, reafirma-se a importância da difusão do conhecimento sobre Andragogia e seus pressupostos, uma vez que proporciona aos professores maior fundamentação teórica e subsídios em suas práticas, possibilitando-lhes ressignificá-las.
COMPREHENSIVE METHOD OF ENERGY-EFFICIENT WORKLOAD PROCESSING IN THE INFORMATION AND COMMUNICATION NETWORK
Authors: Prokopets Nataliia , Globa Larysa 
Published: December 2022

Background. Peculiarities of the workload in a modern information and communication network (ICN) determine specific requirements for energy efficiency, performance and availability of its processing system. Existing approaches to increase energy efficiency and performance of workload processing do not take into account the possibility of dynamic changes in ICN workload arrival rate and individual energy consumption characteristics of computing nodes of the system.
Objective. The purpose of the paper is to increase the energy efficiency and performance of ICN workload processing while meeting the requirements for the availability of the processing system, taking into account dynamic changes in the input workload arrival rate and the individual characteristics of the computing nodes’ energy consumption.
Methods. A mathematical model of the workload processing system was built using the queueing theory methods, and an ontological model of this system was built using intelligent data analysis methods, which made it possible to quantitatively and qualitatively describe the complex relationships between system parameters and workload processing efficiency indicators. On the basis of the built models, a comprehensive method of energy-efficient workload processing was proposed, which differs from the known ones by the use of individual energy consumption models of computing nodes, combining the advantages of horizontal scaling and energy-efficient scheduling taking into account dynamic changes in workload arrival rate.
Results. The efficiency of ICN workload processing is increased by 15.722% according to the efficiency criterion, which includes energy efficiency and performance indicators, compared to the known energy-efficient Backfill approach while meeting the requirements for the availability of the processing system.
Conclusions. The energy efficiency, performance and availability of the ICN workload processing system can be improved by combining horizontal scaling and energy-efficient scheduling approaches using individual energy consumption models of computing nodes and taking into account dynamic changes in the input workload arrival rate.
HEURISTIC ALGORITHMS FOR FINDING THE MINIMUM STEINER TREE IN THE PROBLEM OF OPTIMIZING THE DEPLOYMENT AND MOTION CONTROL OF SEVERAL FLYING INFORMATION AND TELECOMMUNICATION ROBOTS
Authors: Lysenko Olexandr , Valuiskyi Stanislav , Novikov Valeriy , Sushyn Ihor , Chumachenko Serhii , Guida Oleksandr 
Published: December 2022

Background. The article explores the problem of combining the motion control of existing FITRs and the deployment of new FITRs so that the number of new FITRs deployed to support the communication of terrestrial subscribers can be minimized. This problem is formulated as the Steiner Minimum Tree Problem (SMT) with existing mobile Steiner points with a constraint on the edges length of the network graph.
Objective. Improve the mathematical model for ensuring the connectivity of episodic radio networks using FITRs and improve the algorithms for providing the connectivity of episodic radio networks using FITRs.
Methods. The two algorithms (deploying new FITRs before moving existing FITRs, and moving existing FITRs before deployment of new FITRs) separate the problem and solve the deployment problem, the movement one after the other. In contrast, the algorithm for deploying new FITRs while moving existing FITRs optimizes the deployment problem and the control of movement across and solves these two problems simultaneously.
Results. A proposed method includes three heuristic algorithms for placing new FITRs, taking into account the movement of existing FITRs (that is, considering scenarios for moving existing FITRs: deploying new FITRs before, after, or during the movement of existing FITRs) for the SMT problem with existing mobile Steiner points with a constraint on the edges length of the network graph.
Conclusions. Evaluation of the effectiveness of the proposed algorithms in various scenarios shows that algorithms taking into account the movement of existing FITRs are always more efficient (in terms of the number of newly added FITRs) than an algorithm without taking into account the movement of existing FITRs.
Systematic Review of Barriers and Facilitators to Complementary Feeding in Preterm Infants
Authors: Li Jun , Liu Xiyao , Zeng Lin , Zhou Qianling , Han Tongyan 
Published: December 2022

Abstract
Background: It has been reported that preterm infants may experience feeding difficulties in complementary food introduction. There is a lack of a comprehensive summary of the current evidence of the difficulties in complementary food introduction of preterm infants and how to intervene or solve these difficulties. So the purpose of this review is to systematically analyze the difficulties and solutions in the existing literature on it.
Methods: A literature search was conducted in PubMed, Web of Science, Cochrane library and Scopus databases for the studies about complementary feeding in preterm infants. The time range of the search was from January 2012 to December 2021. Included studies were summarized and organized into two perspectives: (1) the difficulties of complementary feeding in preterm infants; (2) related factors influencing feeding difficulties and possible interventions.
Results: A total of 6 articles were included in the systematic review ultimately. Three studies were cross-sectional study and the other three were longitudinal study. The current evidence demonstrated that feeding problems such as vomiting, gagging, food refusal, and chewing and swallowing difficulty might occur in complementary foods introduction in preterm infants. And preterm infants were more likely to experience these difficulties than full-term infants. Possible causes of these feeding difficulties include endotracheal intubation, gastric tube feeding, formula feeding, neonatal surgery, parenteral nutrition, etc. However, the available literatures do not provide specific intervention methods or guidelines to facilitate the complementary feeding in preterm infants.
Conclusions: More experiments are needed to explore appropriate interventions to solve the problems and facilitate complementary feeding in preterm infants during infancy, and promote catch-up growth and develop good eating habits for preterm infants.
Understanding the spatial heterogeneity of Covid-19 vaccination uptake: a case study of England
Authors: Chen Huanfa , Cao Yanjia , Feng Lingru , Zhao Qunshan , Torres José Rafael Verduzco 
Published: December 2022

Abstract

Background
The global Covid-19 pandemic has caused numerous deaths and illnesses, posing unprecedented social and economic challenges to many countries. One of the key strategies to contain the pandemic is mass vaccination programme. However, vaccination rates vary across space and socio-economic factors, and are likely to depend on the accessibility to vaccination services. There is a lack of quantitative understanding of how spatial-socio-economic factors influence the Covid-19 vaccination rates in England.
Methods
We investigated the percentage of over-18 fully vaccinated people at the small-area level across England up to 18 November 2021. We used (multiscale) geographically weighted regression to model the spatially heterogeneous relationship between vaccination rates and socio-economic determinants, including ethnic, age, economic, and accessibility factors.
Results
This study indicates that the selected model can explain 83.2% of the total variance of vaccination rates. The variables exhibiting a positive association with vaccination rates in most areas include proportion of population over 40, car ownership, average household income, and accessibility to vaccination. In contrast, population under 40, low multiple deprivation level, and black or mixed ethnicity are negatively associated with the vaccination rates.
Conclusions
Our findings indicate the importance of improving the spatial accessibility to vaccinations in developing regions and among specific population groups in order to promote Covid-19 vaccination.
Injectable bioactive copper-based metal organic framework embedded dual-crosslinked alginate hydrogel for potential antimicrobial applications
Authors: Gwon Kihak , Lee Seonhwa , Kim Youngmee , Choi Jun , Kim Sujin , Kim Sung-Jin , Hong Hye Jin , Hwang Youngmin , Mori Munemasa , Lee Do Nam 
Published: December 2022

Abstract
Background:
The antibiotic resistance of pathogenic microbes due to the overuse of antibiotics is a growing threat to the public health and can eventually reduce the therapeutic effects of antibiotics. Hydrogel-based systems for local delivery of antibiotics can be a solution to this problem. Metal-organic frameworks (MOFs) have received considerable interest for use as antimicrobial materials due to their high porosity, large surface area to volume, diverse structures, and tunable topologies.
Methods:
In this study, we developed MOF-encapsulated and dual (photo & chemical)-crosslinkable alginate hydrogel as an antimicrobial scaffold. We synthesized antimicrobial Cu(AZPY)-MOF using solvothermal reaction and encapsulated them in an alginate-based hydrogel via visible light photo-crosslinking and calcium ion-induced chemical-crosslinking processes.
Results:
Powder X-ray diffraction, Fourier-transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy confirmed the successful fabrication of Cu(AZPY)-MOF encapsulated alginate hydrogel. The mechanical strength of the dual-crosslinked hydrogels was better than that of the photo-crosslinked hydrogel. Encapsulation of Cu(AZPY)-MOF in an alginate hydrogel resulted in a further increase in the mechanical strength of the hydrogel owing to the additional interaction of alginate with Cu-MOF. Moreover, the Cu(AZPY)-MOF encapsulated alginate hydrogel exhibited excellent antibacterial and antifungal properties against two bacterial strains (i.e., MRSA and S. mutans) and one fungal strain (C. albicans) as well as negligible cytotoxicity toward MEFs.
Conclusions:
The antimicrobial agents encapsulated dual-crosslinkable alginate hydrogel developed in this study is a promising candidate for use in tissue engineering and biomedical field.
A comprehensive mechanistic model of adipocyte signaling with layers of confidence
Authors: Lövfors William , Magnusson Rasmus , Jönsson Cecilia , Gustafsson Mika , Olofsson Charlotta , Cedersund Gunnar , Nyman Elin 
Published: December 2022

Abstract
Adipocyte cellular signaling, normally and in type 2 diabetes, is far from fully understood. We have earlier developed detailed dynamic mathematical models for a number of well-studied, and partially overlapping, signaling pathways in adipocytes. Still, these models only cover a fraction of the total cellular response. For a broader coverage of the response, large-scale phosphoproteomic data and systems level knowledge on protein interactions are key. However, methods to combine detailed dynamic models with large-scale data, using information about the confidence of included interactions, are lacking. Here, we have created a new method where we first establish a core model by connecting our partially overlapping models of adipocyte cellular signaling with focus on: 1) lipolysis and fatty acid release, 2) glucose uptake, and 3) the release of adiponectin. We then use prior knowledge on protein interactions to identify phosphosites downstream of the core model. Using publicly available phosphoproteome data for the insulin response in adipocytes, we test if the identified downstream phosphosites can be added to the model. The additions of the downstream phosphosites are tested in a parallel pairwise approach with low computation time. We iteratively collect the accepted additions into a layer, and use the newly added layer to find new downstream phosphosites. We find that the first 15 layers (60 added phosphosites) with the highest confidence can correctly predict independent inhibitor-data (70-90 \% correct), and that this ability decrease when we add layers of decreasing confidence. In total, 60 layers (3,926 phosphosites) can be added to the model and still keep predictive ability. Finally, we use this large layered model to simulate systems-wide alterations in adipocytes in type 2 diabetes -- simulations made possible for the first time -- with the method developed herein.
What the Phub? Consequences of phone snubbing behavior at work: a mixed-method experiment
Authors: Ochs Carli , Jaunin Astride , Kosnowski Nathalie , Sauer Juergen 
Published: December 2022

Abstract
This mixed-method experiment aimed to investigate the impact of phubbing (i.e. ignoring someone while giving attention to one’s smartphone) on performance, first impressions, and subjective state. 93 participants took part in a simulated job interview based on the Trier Social Stress Test, composed of an interview and a mental arithmetic task. During both tasks, participants in the experimental group were repeatedly phubbed. Results of a within-session analysis revealed that participants in the experimental group performed significantly faster on a mental arithmetic task when they were not phubbed. As expected, phubbed participants judged the interviewer to be less professional and less fair than participants in the control group. Furthermore, the participants’ subjective state was affected by phubbing, with self-esteem decreasing and negative affect increasing. Lastly, a qualitative analysis of participants' responses revealed tendencies to rationalize the interviewer’s phubbing behavior. This study demonstrated negative effects of phubbing on first impressions, subjective state and objective measures of performance in a professional setting.
Nonlinear feedback, double bracket dissipation and port control of Lie-Poisson systems
Authors: Hochgerner Simon 
Published: December 2022

Abstract
Methods from controlled Lagrangians, double bracket dissipation and interconnection and damping assignment -- passivity based control (IDA-PBC) are used to construct nonlinear feedback controls which (asymptotically) stabilize previously unstable equilibria of Lie-Poisson Hamiltonian systems. The results are applied to find an asymptotically stabilizing control for the rotor driven satellite, and a stabilizing control for Hall magnetohydrodynamic flow.
Niche shift and global potential distribution of the invasive species Trioza erytreae, vector of the citrus Huanglongbing disease
Authors: Pérez-Bonet Sergio , López María Ángeles , Abellán Pedro 
Published: December 2022

Abstract
Invasive species pose a major threat to biodiversity, ecological structure of habitats and agriculture, especially in a setting of climatic change. The impact of these species also has a major role in the spread of exotic vector-borne diseases, which may cause substantial economic losses in agriculture if cultivated species are among those affected by these diseases. The African citrus psyllid, Trioza erytreae (Del Guercio), has recently become an invasive species in Europe. This species, which has been known as a pest of trees in the family Rutaceae in Africa for a long period of time, is cause for major concern by its potential effects on citrus orchards, of particular economic importance in southern European countries. Through the evaluation of macroclimatic niches occupied by invasive and native populations and the use of species distribution modelling, we have predicted the potential global geographic distribution of the species, which shows high suitability in a wide range of areas in every continent, as well as quantified and evaluated differences in the macroclimatic niches occupied by invasive and native populations of the species, demonstrating a high similarity and therefore conservatism between the climatic conditions occupied by the species in both ranges. These results provide valuable information that can be used in planning conservation actions in order to reduce risk of invasion by the species.
Up-regulation of miR-208a aggravates high-fat -diet-induced cardiomyocytes injury by targeting IRS-2/PI3K/AKT pathway
Authors: Bi Ye , Wang Yan , Wang Yao , Wang Zhibin , Sun Lan 
Published: December 2022

Abstract
Background: Previous studies found that the myocardial function is damaged in obese mice induced by a high-fat diet, with the increased miRNA-208a and decreased IRS-2.
Method: Herein, miR-208a(-/-) knockout and C57BL/6J wild-type mice were divided into the normal diet and high‑fat diet groups, separately. Expressions of p-IRS-2, PI3K, p-AKT, NPPA, AKT, IRS-2, MYH6, MYH7 and Glut4 were determined using immunohistochemical staining. Furthermore, western blotting was performed to identify proteins.
Cardiomyocytes were isolated from neonatal rats, and the cardiomyocytes injury model was induced by PA. CCK-8 was conducted to assess the viability of cardiomyocytes, and the glucose uptake of cardiomyocytes was measured using glucose uptake test.
Result: H&E staining revealed that the degree of hypertrophy and swelling of cardiomyocytes and cardiac fibrosis of miR208a-/- knockout mice in the high-fat diet group was significantly increased. Moreover, high levels of IRS-2, p-AKT, AKT, NPPA ,GLUT4, MYH7 and MYH6 expression in miR208a-/- knockout mice. Therefore, AKT, MYH6, IRS-2, NPPA in miR208a-/- knockout mice of high-fat diet.
In PA-treated cardiomyocytes, the viability was markedly declined and glucose uptake was significantly reduced, while the lipid accumulation and fibrosis were significantly enhanced. Most importantly, the cardiomyocytes injury induced by PA was aggravated in miR-208a-3p upregulated cardiomyocytes, but alleviated in miR-208a-3pdownregulated cardiomyocytes.
Conclusion: Our results indicate that the high expression of miR-208a promote the suppression of IRS-2/PI3K/AKT signaling pathway. Meanwhile, miR-208a-3p contributes to promoting PA-induced cardiomyocyte injury, which may be a biomarker of cardiomyocyte injury in lipotoxic cardiomyopathy.
Relationships between carboxylate-based nutrient-acquisition strategies, phosphorus-nutritional status and rare earth element accumulation in plants
Authors: Wiche Oliver , Dittrich Christine , Pourret Olivier , Monei Nthati , Heim Juliane , Lambers Hans 
Published: December 2022

Abstract
Background and Aims A split-root approach was used to explore how phosphorus (P) nutrition influences accumulation of rare earth elements (REE) in plant species with different P-acquisition strategies beyond the commonly explored REE-phosphate precipitation.
Methods Six species (Triticum aestivum, Brassica napus, Pisum sativum, Cicer arietinum, Lupinus albus, and Lupinus cosentinii) were cultivated with a split-root system on two sand types. Phosphorus availability was controlled on one root side by watering the plants with different P-containing solutions (100 µM P, 0 µM P). Carboxylate release and changes in pH were measured on both sides. Concentrations of nutrients, cadmium (Cd), aluminium (Al), light REE (LREE: La–Eu), and heavy REE (HREE: Gd–Lu, including Y) in roots and shoots were analyzed by ICP-MS.
Results Triticum aestivum, B. napus and C. arietinum did not respond to a low P supply with elevated carboxylate release. These species accumulated more REE when the P supply was low and higher REE concentrations were proportional to declining plant growth. However, P. sativum, L. albus and L. cosentiniiaccumulated less REE when P-supply was low. Plants that strongly acidified the rhizosphere and released low quantities of dicarboxylates accumulated more REE (with higher LREE/HREE ratios) than species that released tricarboxylates.
Conclusion Our findings suggest that REE accumulation strongly depended on rhizosphere acidification, in concert with the amount and composition of carboxylates determining the exclusion of REE-carboxylate complexes. Leaf REE signatures may be a promising indicator as a screen tool for carboxylate-based processes in the rhizosphere using an ionomic approach.
Zeolite-Y loaded chitosan nanoparticles nanocomposite as endodontic intra-canal medicament: synthesis, antimicrobial and cytotoxic activity: An in vitro study
Authors: Ibrahim Amir I. O. , Moodley Desigar , Maboza Ernest , Olivier Annette , Petrik Leslie 
Published: December 2022

Abstract

Objectives
To synthesize a bioactive nanocomposite intra-canal medicament using chitosan nanoparticles (Ch-Np), loaded into Zeolite-Y as a carrier, and evaluate its antimicrobial activity in the presence and absence of tissue inhibitors. Also, to evaluate its cytotoxic activity against fibroblast cells.
Materials and methods
A concentration of 3% (w/v) electrosprayed Ch-Np was mixed with Zeolite-Y in a concentration of 53.3 (w/v) and characterized using Scanning Electron Microscopy (SEM), and Energy Dispersive Spectroscopy Analysis (EDS). The antimicrobial activity was evaluated against Streptococcus mutans and Enterococcus faecalis using the agar diffusion test, and Time-Kill Test performed by using the broth micro-dilution technique in presence of tissue inhibitors. The cytotoxicity was evaluated against Balb/c 3T3 mouse fibroblast cells using the standard MTT assay.
Results
The mixture resulted in a white paste with a crystalline-like structure under SEM. EDS analysis showed a reduction in the anatomical percentage of Zeolite-Y, indicating cation exchange with Ch-Np. A mean diameter inhibition zones of 9.57 mm for S. mutans and 7.85 mm for E. faecalis were observed, indicating antimicrobial activity. S. mutans and E. faecalis were completely eradicated in the presence of tissue inhibitors. The Ch-Np-Zeolite nanocomposite promotes the growth of 3T3 fibroblast cells significantly (p = 0.00).
Conclusions
Zeolite-Y loaded chitosan nanoparticle nanocomposite completely eradicated S. mutans and E. faecalis even in the presence of tissue inhibitors while maintaining its biocompatibility.
Clinical relevance:
The novel Ch-Np-Zeolite nanocomposite exhibits antimicrobial activity against endodontic pathogens while maintaining its biocompatibility, providing the potential to be used as a novel intra-canal medicament.