bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential effects of lifestyle interventions on continuous glucose monitoring metrics in persons with type 2 diabetes: a randomized cross-over trial
Authors: de Hoogh Iris M. , Snel Tim , Kamstra Regina J.M. , Krone Tanja , de Graaf Albert A. , Pijl Hanno 
Published: January 2025

Abstract

Background
The effects of lifestyle on glucose metabolism significantly differ between individuals. Hyperglycemia in type 2 diabetes is driven by tissue-specific insulin resistance and reduced beta-cell capacity, whose relative contribution varies between persons, potentially affecting the impact of lifestyle interventions. We quantified effects of lifestyle on continuously measured glucose (CGM) metrics and evaluated how these differ between type 2 diabetes phenotypes.
Methods
Forty persons with type 2 diabetes wore a CGM for 11 periods of 4 days, of which 3 control and 4 duplicated intervention periods (2x low carbohydrate diet, 2x Mediterranean diet, 2x walking after each meal and 2x ‘active day’ (hourly 5-minute exercise bouts)). Tissue-specific insulin resistance and beta-cell function were quantified using an OGTT. A linear mixed effects model quantified lifestyle impact on CGM metrics.
Results
On overage, low carbohydrate diet, walking after meal and active day, but not the Mediterranean diet, resulted in lower mean glucose (7.74, 8.37, 8.40 and 8.70 mmol/L, respectively) as compared to control (8.66 mmol/L) in participants who did not restrict carbohydrate intake at baseline. Notably, the magnitude and direction of effects varied between individuals. For instance, the low carbohydrate diet had more beneficial effects for persons who had liver- or combined insulin resistance with poor beta-cell function than for individuals who only had poor beta-cell function.
Conclusions
On average, traditional lifestyle interventions improved CGM metrics within 4 days. Importantly, the effects appear to vary depending on the diabetes phenotype, thus pointing to the need for personalized lifestyle treatment.
Dutch Trial Register: NL7848.
Correlation between Body Mass Index (BMI) and Early Postoperative Pain in Adults Undergoing Arthroscopic Partial Meniscectomy
Authors: Liu Songlang , Liao Hongxing , Yang Yali , Sun Jianguang 
Published: January 2025

Abstract

Background
Arthroscopic partial meniscectomy surgery has become a common treatment for meniscal injuries; however, early postoperative pain significantly affects patient satisfaction with this surgery. Previous studies have largely explored the differences between arthroscopic partial meniscectomy and conservative rehabilitation, as well as factors affecting postoperative quality of life, with less focus on the relationship between the preoperative body mass index (BMI) and early postoperative pain following arthroscopic partial meniscectomy. This study is based on early feedback from patients after arthroscopic meniscal repair surgery, where the primary concern is early postoperative pain, to analyze the correlation between preoperative BMI and early postoperative pain after arthroscopic meniscal repair in adults.
Methods
We retrospectively analyzed clinical data from 221 adult patients who underwent arthroscopic partial meniscectomy at Meizhou People's Hospital, Guangdong Province, China, in 2023. Univariate and multivariate logistic regression analyses, stratified analysis, and threshold effect assessment were employed to evaluate the impact of preoperative BMI, age, sex, disease duration, cartilage injury severity, and meniscal injury grade on postoperative pain. A fitted curve between BMI and postoperative visual analog scale (VAS) score was plotted to visualize the correlation, and the model's efficacy was analyzed via receiver operating characteristic (ROC) curves.
Results
After adjusting for confounding factors through univariate and multivariate analyses, preoperative BMI (β = 0.20, P < 0.01), with an odds ratio of 1.23 and a 95% confidence interval of 1.09–1.38, was identified as a significant factor influencing early postoperative pain. The relationship between the two variables was nonlinear, with a threshold effect revealing BMI = 25.7 as a critical inflection point, where pain significantly changed. The ROC curve analysis indicated that BMI has moderate predictive power for postoperative pain risk (AUC = 0.67).
Conclusion
A significant correlation exists between preoperative BMI and early postoperative pain following arthroscopic partial meniscectomy, with a nonlinear relationship and a key inflection point at BMI = 25.7. This finding can aid in the creation of personalized treatment, management and rehabilitation plans, thus improving patient satisfaction after surgery.
Enhancing Quantum Key Distribution Efficiency and Security
Authors: Ajlouni Naim , Almassri Abdelrahman , Atallah Rasha Ragheb 
Published: January 2025

Abstract

Quantum Key Distribution (QKD) is a cornerstone of next-generation cryptographic technologies, offering unparalleled security by utilizing the principles of quantum mechanics. However, practical implementations of QKD face significant challenges, including inefficiencies in key generation, susceptibility to noise, and vulnerabilities to eavesdropping. This work addresses these challenges by proposing a machine learning (ML)-driven approach to optimize QKD protocols, focusing on enhancing both efficiency and security. In this work it is intended to evaluate three advanced protocols Adaptive, Entanglement-Based, and Hybrid under varying conditions such as key length, noise levels, and channel stability. The ML models will include ensemble learning models namely Random Forest and XGBoost, the models will analyze the impact of key parameters on protocol performance and predict efficiency with high accuracy. The results reveal that the Adaptive protocol significantly outperforms the Entanglement-Based and Hybrid protocols, achieving an efficiency of up to 0.80 for a key length of 2500 bits, compared to 0.24 for the Entanglement-Based protocol and 0.26 for the Hybrid protocol. The Adaptive protocol also demonstrates superior detection probability (ranging from 0.84 to 0.85) and a higher probability of detecting eavesdropping (ranging from 0.43 to 0.45). Furthermore, correlation analysis shows a strong positive relationship (r = 0.9985) between key length and efficiency for the Adaptive protocol, highlighting its scalability. In contrast, the Entanglement-Based protocol shows consistent but lower performance across all metrics, while the Hybrid protocol offers a compromise but remains less efficient than the Adaptive protocol. By integrating ML with quantum cryptography, this work bridges the gap between theoretical advancements and practical implementations, providing a scalable framework for optimizing QKD systems in real-world applications. The findings underscore the importance of protocol design and optimization in achieving secure and efficient quantum communication, paving the way for the quantum internet of the future.
Hypertensive choroidopathy with bilateral serous retinal detachment as the presenting finding in malignant hypertension
Authors: KILINÇ Ali Kutay , AYDIN Ali , BURKE Cahit 
Published: January 2025

Abstract

Background
Secondary hypertension, particularly in young patients, can manifest as malignant hypertension with ocular complications. We report a case of hypertensive choroidopathy with serous retinal detachment as the initial presentation of malignant hypertension in a young woman with renal failure secondary to antimalarial treatment.
Case Presentation:
A 19-year-old woman with a history of renal failure following antimalarial treatment treatment presented with sudden, bilateral vision loss (right eye: 20/200, left eye: 20/40). Fundus examination revealed asymmetrical choroidal involvement with serous retinal detachment, more pronounced in the right eye. Her blood pressure was markedly elevated at 230/130 mmHg. Following blood pressure control with the patient's vision improved to 20/20 in both eyes, and the serous retinal detachments resolved completely.
Conclusion
This case highlights the importance of considering hypertensive choroidopathy in young patients with secondary hypertension presenting with sudden vision loss. Prompt diagnosis and blood pressure management can lead to complete visual recovery.
Progressive speech impairment as the first manifestation of amyotrophic lateral sclerosis: Case report and literature review
Authors: Bernales Jhordan Alexis Paredes , Navarro Henry Flores , Serruto Andre Nelson Sotomayor 
Published: January 2025

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a rare neurodegenerative disease with an incidence of 1.59 per 100,000 people per year. It is characterized by the progressive loss of upper and lower motor neurons, leading to muscle weakness, neuromuscular dysfunction, and eventual severe disability. This case report presents a 62-year-old male patient from Tarapoto who initially exhibited progressive dysarthria as his sole symptom. Two months later, he developed dysphagia for solids and liquids and weakness in his right lower limb. The diagnosis of ALS was established using the revised El Escorial and Awaji-Shima criteria, supported by electromyography findings indicative of acute denervation and chronic reinnervation in multiple segments, including bulbar and thoracic areas. Complementary studies, such as brain tomography, revealed cortico subcortical frontoparietal atrophy without significant findings suggesting other associated pathologies. The patient’s management included physical and speech therapy over multiple sessions, resulting in mild improvements in dysarthria and dysphagia, allowing greater fluency in speech and better tolerance to liquid intake. However, specific pharmacological therapies for ALS, such as riluzole, edaravone, or mitochondrial dysfunction-targeted combinations, were unavailable, limiting the potential to delay disease progression. During his evolution, the patient developed episodes of bronchitis treated with antitussive and mucolytic therapy, with no significant pulmonary complications. Bulbar phenotype ALS, present in 25–30% of cases, poses a diagnostic challenge due to its variable clinical presentation and inevitable progression. This case highlights the importance of comprehensive, multidisciplinary management, including early interventions to address physical, psychological, and social symptoms, as well as palliative strategies to optimize the quality of life for the patient and their family. Although non-pharmacological therapy achieved partial improvements, early access to approved treatments and specialized resources could have provided greater functional and survival benefits.
Bioanalysis, Analysis, Chemistry, and Pharmacological Aspects of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors
Authors: Jain Sunidhi , Patil Roshani , Sharma Sanjay 
Published: January 2025

Abstract:
The development of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIFPHIs),
such as Roxadustat (ROX), Enarodustat (ENA), Desidustat (DES), Vadadustat (VAD), Molidustat
(MOL), and Daprodustat (DAP), has significant effects on anemia in chronic kidney disease.
This review presents comprehensive information about the synthesis, pharmacology, and
analysis of HIF-PHIs across several matrices. The literature has presented several approaches for
quantifying HIF-PHIs in diverse sample matrices. Furthermore, HIF-PHIs exhibit similar modes of
action, demonstrating distinct pharmacokinetic parameters. The pharmacological insights encompass
their half-life, mechanism of action, absorption, distribution, metabolism, excretion, and therapeutic
uses. Research indicates that most studies concentrate on hyphenated methodologies for
drug estimation in various biological fluids. Consequently, this study assesses the biological efficacy
of HIF-PHIs and elucidates the analytical methodologies currently employed for measurement
across various matrices.
Influence of Multidrug Resistance 1 Gene Variants on Response to Intravenous Methylprednisolone Pulse in Systemic Lupus Erythematosus
Patients: Preliminary Results
Authors: Attia Doaa H.S. , Dorgham Dalia Ahmed Hamza , Al Maghraby Ahmed Amin , Abdelrazik Manal B. , Aly Ezzat Dina 
Published: January 2025

Introduction/Objectives:
Genetic variations could explain individual responses to
drugs. This case-control study aimed to investigate the association between the multidrug resistance
1 (MDR1) gene exonic single nucleotide variants (SNVs), rs1128503/C1236T and
rs1045642/C3435T, and the response to intravenous methylprednisolone in Egyptian patients with
active systemic lupus erythematosus (SLE).

Method:
Real-time polymerase chain reaction was used. Patients were divided into responders
and resistant based on the SLE Disease Activity Index (SLEDAI). The degree of improvement
was determined according to a 7-point Likert scale.

Results:
The study included 80 patients: 40 patients with renal flares and 40 patients with extrarenal
flares. In patients with extrarenal flares, 71.4% of responders had the CT+TT model of the
C1236T variant versus 36.8% of resistant patients (p = 0.028); the T allele was detected in 47.6%
of responders versus 23.7% of resistant patients (p = 0.026). Patients with the TT and CT genotypes,
TT+CT model, and T allele of the C1236T variant had significant improvement based on
the Likert scale compared with the CC genotype, CC model and C allele (p = 0.049, 0.038, 0.010
and <0.001, respectively). In the renal subgroup, patients with the CC genotype and C allele of the
C3435T variant had significant improvement based on the Likert scale compared with the CT
genotype and T allele (p = 0.028 and 0.046, respectively). Patients with the CC model had significantly
lower post-treatment proteinuria compared with the TT+CT model (p = 0.024).

Conclusion:
MDR1 C1236T variant allele and C3435T wild allele seem to enhance the response
to glucocorticoids in Egyptian patients with active SLE.
Date Palm Fruit (Phoenix dactylifera L.) Ameliorated Some Premenstrual
Symptoms: Results from an Intervention Trial for 5 Consecutive Menstrual
Cycles
Authors: Al-Sayyed Hiba F. , Takruri Hamed R. , Bakir Nawal A. , Takruri Dima H. , Hamed Nour M. , Rizeq Lana T. , Sweidan Dima H. 
Published: January 2025

Introduction/Objectives:
Premenstrual syndrome (PMS) is the group of symptoms that
occur before menses and remit after that. The pathophysiology of PMS is related to hormonal disturbances.
Date palm fruit (Phoenix dactylifera L.) has many functional properties that are beneficial
for women's health. This study aimed to investigate the effect of feeding dates on PMS symptoms.

Method:
The fruit was fed conveniently to 36 volunteers, 16 and 20 in the control and dates
groups, respectively. To monitor PM symptoms, a questionnaire was developed, validated, and
tested for reliability.

Results:
Results of this research yielded a valid (KMO, Barlett factor, and ꭕ2 test values of 0.541,
<0.001, and 0.105 respectively) reliable (Cronbach’s-α value= 0.761) questionnaire. Feeding dates
caused earlier onset of mood changes (0.017*), heavy bleeding (0.012*), and bleeding clots
(0.025*). The onset of mood changes correlated significantly (P=0.048*) and negatively (r2= -
0.347) with luteinizing hormone. Additionally, prolactin was correlated significantly and negatively
with the onset of abdominal cramps. Within the same line, progesterone was correlated negatively
with vaginal secretions (r2= - 0.389, P=0.016*). On the other hand, breast tenderness was
correlated (r2=0.391) significantly (P=0.022*) with 17-β-estradiol.

Conclusion:
This study showed an ameliorating effect of dates on some PMS symptoms, i.e., abdominal
cramps, mood changes, heavy bleeding, vaginal secretions, and bleeding clots.
Effect of Oral Posaconazole on Venetoclax Plasma Concentration and its Efficacy in Patients with Acute Myeloid Leukemia
Authors: Guo Mengqi , He Yingzhi , Du Jingwen , Qiu Dezhi , Qin Yinjie , Huang Yuxian 
Published: January 2025

Background:
BCL-2 was the first gene identified to have antiapoptotic effects, and
venetoclax is an oral selective BCL-2 inhibitor, which has great potential in the treatment of patients
with acute myeloid leukemia (AML) who are not candidates for intensive therapy. Notably,
posaconazole, an oral antifungal drug, is also a strong factor that can affect blood venetoclax concentrations.
To the best of our knowledge, the relationship between BCL-2 expression, posaconazole,
and venetoclax, as well as their influence on treatment efficacy and the prognosis of patients
with AML, has not been reported.

Objectives:
In this single-center retrospective study, the relationship between BCL-2 expression
and blood venetoclax concentration was analyzed in 35 patients with AML. After that, we explored
the differences in curative effect, adverse reactions, and outcomes between patients with
different BCL-2 expression levels and patients with different venetoclax concentration levels, respectively.

Methods:
BCL-2 mRNA expression levels were examined by reverse transcription quantitative
PCR. Blood venetoclax concentrations were measured using high-performance liquid chromatography-
tandem mass spectrometry.

Results:
The results revealed that among patients with AML, those with lower primary BCL-2 expression
had a higher complete remission (CR) rate (p =0.005), overall response (OR) rate (p
<0.0001), and progression-free survival time (p =0.04). Posaconazole was revealed to be a strong
factor that was able to increase blood venetoclax concentration (p <0.001) and CR rate in the venetoclax
plus posaconazole group compared to that in the venetoclax monotherapy group (p
=0.002); however, no significant difference was identified in the occurrence of adverse reactions
between these groups. Among low and high-blood venetoclax concentration groups, the event-free
survival of the former group was significantly higher (p =0.013).

Conclusion:
Higher levels of BCL-2 expression at initial diagnosis may have adverse effects on
the efficacy and prognosis of patients, and higher levels of venetoclax concentration may advance
the time of adverse reactions in patients, thus adversely affecting event-free survival (EFS).
A Deep Learning Method for Identifying G-Protein Coupled Receptors based on a Feature Pyramid Network and Attention Mechanism
Authors: Lv Zhe , Hu Siqin , Wei Xin , Qiu Wangren 
Published: January 2025

Background:
G-protein coupled receptors (GPCRs) represent a large family of membrane
proteins, distinguished by their seven-transmembrane helical structures. These receptors play a pivotal
role in numerous physiological processes. Nowadays, many researchers have proposed computational
methods to identify GPCRs. In the past, we introduced a powerful method, EMCBOW-GPCR,
which was designed for this purpose. However, the feature extraction technique employed is susceptible
to out-of-vocabulary errors, indicating the potential for enhanced accuracy in GPCR identification.

Methods:
To solve the challenges, we propose a novel approach termed GPCR-AFPN. This method
leverages the FastText algorithm to effectively extract features from protein sequences. Additionally,
it employs a powerful deep neural network as the predictive model to improve prediction accuracy.

Results:
To validate the efficacy of the proposed GPCR-AFPN method, we conducted five-fold
cross-validation and independent tests, respectively. The experimental results indicate that GPCRAFPN
outperforms existing methods.

Conclusion:
Overall, our proposed method, GPCR-AFPN, can improve the accuracy of GPCR identification.
For the convenience of researchers interested in applying our latest advancements, a userfriendly
webserver for GPCR-AFPN is available at www.lzzzlab.top/gpcrafpn/, and the corresponding
code can be downloaded at https://github.com/454170054/GPCR-AFPN.

conclusion:
GPCR-AFPN has a significant advantage for the identification of GPCRs compared to the current state-of-the-art methods of the field.

other:
For the convenience of researchers interested in applying our latest advancements, a user-friendly webserver for GPCR-AFPN is available at http://47.121.208.99/gpcrafpn/ and the corresponding code can be downloaded at https://github.com/454170054/GPCR-AFPN.
Rare of Gaucher's Disease Complication of Splenic Multiple Gaucheroma
Authors: Çukadar Nursima , Vezi̇roğlu İrem Erdoğan , Kara Canan Sehit , Karahan Okkes Ibrahim , Talih Tutkun , Bayram Fahri 
Published: January 2025

Background:
Gaucheromas, pseudotumors composed of Gaucher cells, are rare complications
of Gaucher’s Disease (GD). They are usually seen in patients receiving enzyme replacement.
Surgery is generally not recommended for these benign masses in treatment management.
Most patients treated with Enzyme Replacement Therapy (ERT) show organ enlargement and improvement
in laboratory values. In our case, no change in the size of the lesions was observed despite
4 years of standard dose ERT.

Case presentation:
A 27-year-old female, not having a known chronic disease and occasionally
consulting doctors due to bone pain, weakness, and fatigue, visited the emergency department
with the complaint of a nosebleed four years ago. The patient was found to have hepatosplenomegaly
in physical examination and was referred to the hematology clinic because of pancytopenia.
According to the physical examination and laboratory results, the desired leukocyte glucocerebrosidase
level was 0.4 micromol/lt/hour (normal range > 2.5). Homozygous mutations of
p.L483P and L483P were observed in genetic tests. Based on these results, the patient was diagnosed
with GD. Although the patient received regular weekly treatment for 4 years, no significant
change was observed in the spleen size. The patient was admitted to the hospital in April 2022
with complaints of abdominal fullness and indigestion. Her quality of life was deteriorating due to
massive splenomegaly. A splenectomy was performed on the patient. In our case, splenic
gaucheroma, a rare complication of Gaucher’s disease, was found to be present.

Conclusion:
These masses, which are a rare complication of GD, have started to be better recognized
by radiologists and clinicians thanks to the case series shared, and it is clear that there is a
need for standardization and further research in this field. With an increase in the number of cases
and experiences in this field, there will inevitably be different and new developments in follow-up
and treatment approaches.