bluuebunny/crossref_metadata_2025_split huggingface dataset:
Densified mixture design algorithm: A novel mix design concept and its application for green concretes incorporating industrial by‐products
Authors: Nguyen Tan‐Hung , Limongan Andrian H. , Nguyen May Huu , Hwang Chao‐Lung , Huynh Trong‐Phuoc 
Published: January 2023

AbstractDespite the fact that densified mixture design algorithm (DMDA) has been identified as a promising tool for green concrete mix design, its use in real practice has still been minimal worldwide. Due to the lack of precise information on DMDA computation in earlier studies, this work proposes DMDA including fly ash and ground granulated blast‐furnace slag as a viable way to improve the long‐term performance of green concrete. To encourage the use of DMDA, this study offers a detailed description of the DMDA mix design, as well as a step‐by‐step standard operating procedure and an empirical example of the computation. Assessments of the long‐term performance of green mixtures (self‐consolidating concrete and high‐performance concrete) and ordinary Portland cement concrete (designed using the conventional method of American Concrete Institute, ACI) were made. Performances of the ACI (O6000 mixture) and DMDA concretes (S6000 and H6000 mixtures) were then compared in terms of compressive strength, elastic modulus, shrinkage, and creep strain. As a result, all of the concrete samples attained the target strength of above 41 MPa (6000 psi) after only 28 days. Moreover, compressive strength, elastic modulus, shrinkage, and creep strain increased significantly in all of the concretes over curing time. Importantly, the experimental results confirmed that both types of DMDA concrete exhibited higher compressive strength and better long‐term performance than the ACI concrete under elastic modulus, creep, and shrinkage aspects.
Analysis on temporal variation law of ozone pollution and meteorological driving factors in Pudong New Area of Shanghai
Authors: Guan Jie , Geng Zhixin , Yang Fan , Zhang Xiaojiao , Chen Shuai , Guo Yaoguang 
Published: January 2023

AbstractIn order to deeply understand the influence of meteorological drivers on ozone (O3) pollution during the high season and explore O3 pollution control options, we analyzed the temporal variation characteristics of O3 pollution based on the ambient air observation data of Pudong New Area, Shanghai from 2020 to 2021, studied the influence of meteorological drivers on O3 pollution, and explored seasonal emission reduction options based on the results of EKMA (Empirical Kinetics Modeling Approach) curves. The results show that the seasonal O3 concentration variation is spring > summer > autumn > winter; relative humidity, temperature and wind speed are the main meteorological drivers of O3 pollution; the cross‐regional transport of high O3 concentrations and precursors from the south and southwest has a strong influence on the local O3 concentration; Pudong New Area is in the “VOCs control zone” during the O3 pollution period in May. Therefore, it is important to control the production and emission of local VOCs and to strengthen the synergistic control of O3 and its precursors between regions for the control of spring O3 in Pudong New Area.
Potential application of domestic solar dryers for coriander leaves: Drying kinetics, thermal efficiency, and quality assessment
Authors: Kaur Sukhanjot , Singh Manpreet , Zalpouri Ruchika , Kaur Kulwinder 
Published: January 2023

AbstractCoriander (Coriandrum sativum L.) is a highly perishable crop with a shelf‐life of a few days under refrigerated conditions. Solar drying is one of the economical, hygienic and eco‐friendly methods of food preservation. During this study, fresh coriander was pre‐treated in a solution of 0.1% magnesium chloride, 0.1% sodium bicarbonate and 2.0% KMS for 15 min before solar or open sun drying. There were two types of solar dryers used, namely: PAU advanced domestic solar dryer and PAU domestic solar dryer. Solar dryers were evaluated and compared with open sun drying for drying kinetics, thermal efficiency, and product quality. The quality parameters determined were total color difference, total flavonoid content, total chlorophyll content, and ascorbic acid content. For drying of coriander, ADSD achieved the maximum thermal efficiency (18.56%) and minimum solar energy input (12.56 MJ/kg) out of the various drying systems under consideration. Additionally, ADSD samples had the highest quality retention in terms of the highest total flavonoid content (1.23 mg/100 g), total chlorophyll content (24.14 mg/100 g) and ascorbic acid content (24.29 mg/100 g).
Analysis and prediction of plastic waste composite construction material properties using machine learning techniques
Authors: Jain Devansh , Bhadauria Sudhir Singh , Kushwah Suresh Singh 
Published: January 2023

AbstractThe use of plastic‐based composites as building materials may be one method of recycling plastic waste. Plastic pollution has emerged as a global issue since our planet is becoming increasingly engulfed in plastic waste. In order to preserve a long‐term sustainable ecosystem, alternative methods of recycling this plastic trash would be extremely beneficial. In this study, the six attributes, which are ingredients used to make plastic composite construction material, are used to predict five target variables or properties of plastic composite construction material, such as compressive strength, flexural strength, split tensile strength, density, and water absorption. Five machine learning techniques random forest, Decision Tree, Ridge, Lasso, and Linear regression have been used to get the best prediction model for the properties of plastic composite construction material. The correlation method has been used to analyze the relationships among the properties and ingredients of plastic composite construction material. Analytical results for K‐fold cross‐validation show that random forest and decision tree form the best predictive models, having greater prediction accuracy than the rest of the machine learning algorithms. This pioneering work provides a simple and convenient method for predicting various properties of plastic‐based composite construction material and finding the impact of each composition mix on various properties.
Developing smart city services using intent‐aware recommendation systems: A survey
Authors: Rafique Wajid , Hafid Abdelhakim Senhaji , Qadir Junaid 
Published: January 2023

AbstractSmart cities could be defined as urban areas that use Information and Communication Technology (ICT) to solve city problems in efficient and sustainable ways. Intent‐aware Recommender Systems (IARS) within ICT play a crucial role in filtering useless information according to user demands and assist in decision‐making in various smart city platforms. In smart cities, the user traces on IoT, RFIDs, mobiles, and smart sensors capture actual user intent of performing an activity and enhance user satisfaction by proposing optimal services. This paper presents a detailed literature survey of the field of IARS and how it can be used for developing smart city services. First, we present the evolution of IARS with the development of computing technology. Then, we present case studies, synergies, advances, and a reference implementation architecture of IARS for smart cities. We discuss requirements for developing smart city services using IARS. Furthermore, we devise a comprehensive taxonomy of applications and techniques of IARS using different performance parameters. Finally, we elaborate on current issues, challenges, and future research directions in IARS; these directions we believe will pave the way for autonomous service provisioning in smart cities.
Life‐space mobility among home‐living older adults with care needs and clinical depression—A cross‐sectional analysis
Authors: Lech Sonia , Mümken Sandra , Kessler Eva‐Marie , Gellert Paul 
Published: January 2023

AbstractObjectivesWhile life‐space mobility is key for wellbeing, social participation and access to health care, vulnerable older adults face physical and mental barriers that may restrict mobility. The present exploratory study examined associations between physical functional limitations, depressive symptoms, life‐space mobility and outpatient health care utilization.MethodsCross‐sectional data from 197 community‐dwelling older adults with care needs and clinical depression was collected. Life‐space assessment composite score (LS‐C), instrumental activities of daily living scale (iADL), Geriatric Depression Scale (GDS‐12) and outpatient health care utilization have been assessed. Multiple regression analyses were conducted.ResultsMean LS‐C score was 31.8 (SD = 17.7, range: 0–92), indicating low mobility levels. Depressive symptoms (β = −0.21, p = 0.001) and iADL (β = 0.54, p < 0.001) were significantly related with life‐space mobility, over and above age and living alone. An interaction effect between depressive symptoms and iADL was not significant (β = −0.07, 0.17, p = 0.26). Moreover, life‐space mobility was positively associated with primary care (β = 0.19, p = 0.02) and mental health care utilization (β = 0.33, p < 0.001).ConclusionsLife‐space mobility appears to be largely restricted in home‐living vulnerable older adults with clinically significant depression; and factors associated with these restrictions appear to be physical and mental. The interplay of depression, mobility and health care utilization and its potential for interventional approaches need further investigations. Present findings underline an urgent need for new health care services that allow mobility‐impaired older patients to receive mental health outpatient treatment in their own home.Clinical trial registrationThe trial was prospectively registered with the ISRCTN registry (Trial registration number: ISRCTN55646265, registered February 15, 2019).
Using insights from personality dynamics to move developmental metatheory forward: Integrating insights from relational developmental systems metatheory and whole trait theory
Authors: Dykhuis Elise M. , Warren Michael T. , Meindl Peter , Jayawickreme Eranda 
Published: January 2023

AbstractDevelopmental science benefits from a rich tradition of conceptual frameworks, such as Relational Developmental Systems metatheory, that seek to understand the individual ⇔ context relations that promote thriving across the lifespan. However, there are substantive methodological challenges associated with capturing individual‐level and contextual variables, let alone the dynamics between them. These challenges have encouraged the perpetuation of simple models that focus on either individuals or their contexts alone, or as parallel processes with little attention to the dynamics of the relations. In this paper, we engage in cross‐disciplinary dialogue between developmental and personality science (adding to recent work being done by those in personality development) and highlight the benefits that developmental science can reap by adopting several recent advancements in dynamic personality theory and the methods used to test them. In addition, we discuss what personality science might gain from applying a developmental lens to their research questions. Such integration may also help personality scientists better understand how developmental theory can complement their methods for understanding the development of individual differences over time. Ultimately, the two fields can use their similar missions of understanding the development of individual differences in order to support one another in pursuing good science.
Exploration of immunotherapy in advanced pulmonary lymphoepithelioma‐like carcinoma
Authors: Pang Lan‐Lan , Liao Jun , Huang Yi‐Hua , Gan Jia‐Di , Zhuang Wei‐Tao , Lv Yi , Liang Wei‐Ting , Zhang Li , Fang Wen‐Feng 
Published: January 2023

AbstractPulmonary lymphoepithelioma‐like carcinoma (PLELC) is a rare and histologically distinctive subtype of nonsmall cell lung cancer (NSCLC). High expression of programmed death ligand 1 (PD‐L1) and scarcity of druggable driver mutations raise the potential of immunotherapy for advanced PELEC. However, evidence on the clinical impact of immune‐checkpoint inhibitors (ICIs) remained limited and unconvincing. The present study retrospectively enrolled advanced PLELC patients who received ICIs either as up‐front or salvage therapy in SYSUCC between March 15, 2017 and March 15, 2022. The comparative efficacy of chemoimmunotherapy vs chemotherapy in the first‐line setting and chemoimmunotherapy vs ICIs monotherapy in the ≥2 line setting was investigated. A total of 96 patients were finally enrolled; 49 PLELC patients received immunotherapy plus platinum‐based chemotherapy, while 45 patients received platinum‐based chemotherapy as first‐line treatment. Patients with chemoimmunotherapy significantly obtain more survival benefits than those receiving chemotherapy (median progression‐free survival [PFS]: 15.6 vs 8.6 months, P = .0015). Additionally, patients with chemoimmunotherapy obtained more PFS benefits than those with ICIs monotherapy in the ≥2 line of therapy (median PFS: 21.7 months vs 7.8 months, P = .094). A significant correlation was observed between prognostic nutritional index (PNI) and favorable treatment outcomes in patients receiving first‐line chemoimmunotherapy (median PFS: 17.8 months vs 7.6 months, P < .0001). Likewise, patients in the monocyte‐to‐lymphocyte ratio (MLR)‐high group had significantly shorter PFS than the MLR‐low group (median PFS: 11.2 months vs not reached, P = .0009). Our study elucidated the superior efficacy of ICIs therapy, especially chemoimmunotherapy in advanced PLELC, which may provide new insight into the role of immunotherapy in advanced PLELC.
A study of the role of multiple layer‐by‐layer assembled bionic extracellular matrix in promoting wound healing via activation of the Wnt signaling pathway
Authors: Wang Zehui , Cao Kun , Yan Di , Ge Yangjing , Li Ruiyuan , Liu Yanwen , Ma Ting , Sun Xiaojuan 
Published: January 2023

AbstractWound healing is a multicellular collaborative process in which the adhesion and proliferation of fibroblasts in the wound is the basis for ensuring rapid wound healing, and in this process, it can promote the regeneration and remodeling of tissue and extracellular matrix. Studies have shown that Arg‐Gly‐Asp adhesive peptide (RGD) and basic fibroblast growth factor (bFGF) can stimulate the adhesion and proliferation of fibroblasts by activating the Wnt/β‐catenin signaling pathway, respectively. This study adopts the principle of layer‐by‐layer self‐assembly, and the binding force formed by electrostatic attraction and Schiff base was used to combine bFGF and RGD with collagen membrane to form a biomimetic membrane that is non‐cytotoxic with strong biocompatibility that could promote soft tissue healing. The surface characteristics of MLCM and the sustained release concentration of bFGF in vitro were measured, and the effects of MLCM on cell viability, proliferation, migration, and wound healing by means of Wnt/catenin pathways were studied through cell experiments and animal experiments under the comparison of negative control groups and positive control groups. The results showed that MLCM could stimulate wound healing more actively and had a positive effect on cell activity, proliferation, and migration. During wound healing, MLCM activates the Wnt/β‐catenin signaling pathway and inhibition of Wnt/β‐catenin signaling pathway significantly reduces the positive effects of MLCM on wound healing.
Inhibition of autophagic flux by the curcumin analog EF‐24 and its antiproliferative effect on MCF‐7 cancer cells
Authors: Li Jun , Wang Song‐He , Liu Yang‐Ting , Zhang Qin , Zhou Guang‐Zhou 
Published: January 2023

Abstract5‐Bis[(2‐fluorophenyl)methylene]‐4‐piperidinone (EF‐24) is a curcumin analog, which was identified for its physiochemical stability and diverse pharmacological functions. In the present study, EF‐24 was added to the breast cancer cell line MCF‐7 and its cellular effects were characterized. The results indicated that EF‐24 possessed antiproliferative and antimigratory activities on MCF‐7 cells as determined by MTT assay, wound healing, and transwell assay, respectively. In addition, the autophagosomal vesicles could be detected by acridine orange staining and electron microscope analysis in EF‐24‐treated cells. Conversion of LC3‐I to LC3‐II was also investigated following EF‐24 treatment of the cells. However, the expression analysis of p62 and LC3 revealed that EF‐24 could inhibit autophagic flux in MCF‐7 cells. Confocal microscopy suggested that EF‐24 could inhibit the degradation of autophagic vesicles by blocking the fusion of autophagosomes with lysosomes. EF‐24 could also induce apoptosis of MCF‐7 cells as determined by Hoechst 33342 staining, flow cytometry analysis, and western blot analysis. Moreover, treatment of the cells with the autophagy inhibitor 3‐MA enhanced the PARP1 cleavage of EF‐24‐treated MCF‐7 cells, which indicated the crosstalk between autophagy and apoptosis in breast cancer cells. Additional investigation of EF‐24 should be performed in future studies to assess its antiproliferation and antimigratory effects on MCF‐7 cells. However, the current results provide a solid foundation for the potential in vivo anticancer activity of this compound.
Facial and opercular muscles in the Anguilliformes (Elopomorpha: Teleostei): Comparative anatomy and phylogenetic implications for the basal position of Protanguilla
Authors: Espíndola Vinicius C. , Johnson G. David , De Pinna Mario C. C. 
Published: January 2023

AbstractThe teleost order Anguilliformes, true eels, comprises more than 1000 described species in 20 families, commonly known as eels, congers, morays, and gulper eels. Comprehensive studies of Anguilliformes are limited, resulting in a lack of consensus for morphology‐based phylogenetic hypotheses. A detailed morphological analysis of the cephalic and opercular myology offers a promising new source of characters to help elucidate the intrarelationships of Anguilliformes. Our study is the most extensive myological analysis for the group and includes 97 terminal taxa, with representatives from each of the 20 families of Anguilliformes plus outgroup clades. Results demonstrate that muscle characters inform phylogenetic relationships within Anguilliformes, and we propose two new synapomorphies for all extant members, including Protanguilla palau, the “living fossil”—adductor mandibulae originating on the parietal (vs. restricted to suspensorium) and segmentum mandibularis absent (vs. present). Exceptions for the first condition characterize highly modified saccopharyngoids, and for the second one, Notacanthidae. More importantly, we suggest three new synapomorphies for the remaining extant anguilliforms (except in highly modified saccopharyngoids)—adductor mandibulae originates on the frontals (vs. frontals naked), adductor mandibulae stegalis is separated from the rictalis (vs. ricto‐stegalis fused into a single piece), and the levator operculi inserts on the lateral surface of the opercle (vs. medial surface of the opercle). Our phylogenetic optimization strongly corroborates the hypothesis that Protanguilla is the sister group of all other extant eels. A further goal of this paper is to clearly document the substantive conflicts between the available molecular data and the extensive and diverse morphological evidence.
Estimation of tropical cyclone (TC) rainfall risk in South Korea using the integrated TC track and semi‐physical TC rainfall models
Authors: Alcantara Angelika L. , Ahn Kuk‐Hyun 
Published: January 2023

AbstractUtilizing historical records is limited in estimating the full distribution of plausible tropical cyclone (TC) risk due to insufficient samples. To alleviate this limitation, this study presents a semi‐physical TC rainfall model to produce spatially and temporally resolved TC rainfall sequences for a proper TC risk assessment. The model incorporates a statistical‐based track model that follows the Markov renewal process to generate synthetic TC tracks for any number of years, with a physics‐based model that acknowledges the interaction between TCs and the environment to generate tropical cyclone rainfall. After simulating the TC rainfall data, we then fit it to a probability distribution function to explore the spatially heterogeneous risk induced by landfalling TCs. The procedure is applied in South Korea as a case study to conduct a country‐scale‐based vulnerability evaluation from damaging TC impacts. As a result, we show that the proposed TC model is promising in producing sufficient numbers of TC tracks that do not only follow the spatial distribution of the historical data but also reveal hidden paths that could be utilized in examining scenarios outside what have been historically observed. Results also demonstrate that the model is suitable for properly estimating the amount of TC‐induced rainfall across various locations over the study area. The generated TC rainfall sequences allow us to reliably characterize higher return periods that are often underestimated or overlooked when the observed data is employed due to sampling limitations. Moreover, our model can properly capture the distribution of rainfall extremes that follow a heterogeneous pattern throughout the study area and vary per return period. Overall, our results show that the proposed approach is effective in providing sufficient TC sequences that could help in improving TC risk assessment.
Recognizing neonatal refeeding syndrome and thiamin supplementation: A case report
Authors: Bradley Caitlin , Hansen Anne , Levy Philip , Hashim Emily 
Published: January 2023

AbstractRefeeding syndrome (RS) is a condition characterized by electrolyte derangements, thiamin deficiency, and organ dysfunction after the provision of nutrition to an individual who had been deprived of nutrients. Published guidelines outlining the recognition and definition of RS exist for adult and children, but there are limited newborn‐specific guidelines because of a paucity of available literature and variation in reporting. We describe a small‐for‐gestational‐age, full‐term newborn with neonatal encephalopathy who underwent therapeutic hypothermia. Electrolyte derangements and lactic acidosis developed and persisted after the introduction of intravenous nutrition. After the exclusion of other etiologies, neonatal RS was suspected, and the newborn was treated with thiamin. We provide a brief review of the current literature on neonatal RS, present a case report consistent with neonatal RS, and provide suggestions for the utility of thiamin replacement in newborns with suspected neonatal RS.