bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative evaluation the rationality of the use of FOLFOX regimen in patients with metastatic colorectal cancer based on AHP weighted TOPSIS method
Authors: Zou Jian , Zhong Jia-yun , Zou Rui , Huang Dan , Liu Yu , Liu Yan-xin , Gong Wen-jun , Li Xi-wen , Tao Jia , Yang Xiao-lai 
Published: September 2023

Abstract
Purpose
Adopts Analytic Hierarchy Process (AHP) and Technique for Order Preference by Similarity to Ideal Situation (TOPSIS) to assess and rank different indicators of evaluation index and evaluate the rationality of the use of FOLFOX regimen in patients with metastatic CRC.
Methods
The evaluation criteria for the rationality of the use of FOLFOX regimen was established with reference to the dispensatory and application guidelines by using AHP weight, and TOPSIS method was adopts to retrospectively analyze and evaluate the rationality of the use of FOLFOX regimen in 176 cases in the medical records of our hospital from July to December 2022.
Results
Established evaluation criteria included 3 primary indexes (indication, medication process, management indicator) and 18 secondary parameters. Chemotherapy regimens selection, therapeutic evaluation and discontinuation of drug indications ranked top 3 secondary parameters (relative weight coefficient were 0.08352, 0.06257, 0.06217, respectively). The primary inappropriate types and scores of FOLFOX regimen were preconditioning, dose selection and therapeutic evaluation (deducted scores were 429.44, 416.97, 306.59 respectively). Among 176 cases, 49 cases (27.84%) had a relative proximity (Ci) equal to 100%, 87 cases (49.43%) 100%-80%, 29 cases (16.48%) 80%-60% and 11 cases (6.25%) below to 60%. The major problems were vomiting risk was not assessed (16.13%), insufficient dose of cytotoxic agents (15.66%) and treatment effects were not evaluated according to WHO standards (11.52%).
Conclusions
The evaluation criteria of the rationality of clinical application of FOLFOX regimen were established by AHP-TOPSIS method. The evaluation results obtained by this method were quantifiable, scientific and credible. The phenomenon of irrational use of these drugs in our hospital is relatively common, and the management should be strengthened in clinical application.
Implications for cancer survivors
AHP weighted TOPSIS method can quantitatively evaluate the rationality of anti-cancer drugs by integrating multiple indicators.
Conformal Invariance of Clifford Monogenic Functions in the Indefinite Signature Case
Authors: Liang Chen , Libine Matvei 
Published: September 2023

Abstract

We extend constructions of classical Clifford analysis to the case of indefinite non-degenerate quadratic forms. Clifford analogues of complex holomorphic functions -- called monogenic functions -- are defined by means of the Dirac operators that factor a certain wave operator. One of the fundamental features of quaternionic analysis is the invariance of quaternionic analogues of holomorphic function under conformal (or Mobius) transformations. A similar invariance property is known to hold in the context of Clifford algebras associated to positive definite quadratic forms. We generalize these results to the case of Clifford algebras associated to all non-degenerate quadratic forms. This result puts the indefinite signature case on the same footing as the classical positive definite case.
Friction and Wear Performance of High Carbon Grey Cast Iron
Authors: Chen Tiefang , Wang Chenggang , Yan Ruifang , Li Feng , Wang Jiandong , Wang Jinguo 
Published: September 2023

Abstract
In this paper, the friction and wear properties of gray cast iron with different carbon content at different ambient temperatures and the failure forms of gray cast iron friction and wear are studied, which has a certain guiding significance for the manufacture of gray cast iron brake discs. The research concludes that under low-temperature wear conditions, the graphite in the gray cast iron structure can enter into the interface between the friction pair, have a lubricating effect on the wear surface, and reduce the friction coefficient and wear loss of the gray cast iron material. As the graphite content in the gray cast iron structure increases, the lubrication and protection effect of the graphite increases, and the wear failure of gray cast iron is mainly caused by plastic deformation-induced fatigue peeling. Under high-temperature wear conditions, an oxide layer gradually forms on the wear surface. With the increase of experiment temperature, the thickness of the oxide layer increases on the wear surface. When the oxide layer formed on the wear surface reaches a certain level of thickness, the internal expansion stress of the oxide layer increases considerably, causing the oxide layer to peel off and increase the roughness of the wear surface, friction coefficient, and wear loss. Additionally, with the increase of the graphite content in the gray cast iron structure, the surface is more prone to oxidation, leading to the increase of friction coefficient and wear loss. The wear failure of gray cast iron is mainly caused by oxidation layer peeling.
Identification and expression analysis of the SKP1-like gene family under phytohormone and abiotic stresses in apple (Malus domestica)
Authors: Shao Miao , Wang Ping , Gou Huimin , Ma ZongHuan , Chen Baihong , Mao Juan 
Published: September 2023

Abstract
Background
Ubiquitination participated in plant hormone signaling and stress response to adversity. SKP1-Like, a core component of the SCF (Skp1-Cullin-F-box) complex, is the final step in catalyzing the ubiquitin-mediated protein degradation pathway. However, the SKP1-Like gene family has not been well characterized in response to abiotic stresses and hormonal treatments in apple.
Results
Our study revealed that 17 MdSKP1-Like gene family members with conserved domain of SKP1 were identified in apples and were unevenly distributed on eight chromosomes. And the MdSKP1-Like genes located on chromosomes 1, 10 and 15 were highly homologous. The MdSKP1-like genes were divided into 2 subfamilies according to the evolutionary affinities of monocotyledons and dicotyledons. MdSKP1-like members of the same group or subgroup show some similarity in gene structure and conserved motifs. The predicted results of protein interactions showed that members of the MdSKP1 class family have strong interactions with members of the F-Box family of proteins. Selection pressure analysis showed that MdSKP1-Like gene were in purifying selection. Tissue-specific expression analysis showed that most MdSKP1-Like gene family members were highly expressed in flowers and leaves. We also found that the upstream cis-elements of MdSKP1-Like genes contained a variety of elements related to light regulation, drought, low temperature, many hormone response elements, etc. Thus, qRT-PCR also confirmed that the MdSKP1-Like gene is indeed involved in the response of apple to hormonal and abiotic stress treatments.
Conclusions
Our research provides some theories for regulating MdSKP1-Like gene expression in response to hormonal and abiotic stresses to improve stress resistance in apples.
Fetal Head-to-Perineum Distance as a Predictor of Successful Vaginal Delivery: A Secondary Analysis of Intrapartum Ultrasound Data
Authors: Horst Wagner , Valle Juliana Barros do , Godoy Eduardo Duarte Pinto , Silva Jean Carl 
Published: September 2023

Abstract

Purpose:
The primary aim of this secondary analysis is to assess the clinical utility of intrapartum ultrasound measurements of the fetal head-to-perineum distance (HPD) as a predictor for successful vaginal delivery.
Methods:
This secondary analysis was conducted on a cross-sectional study involving 33 pregnant women admitted for labor. HPD was measured using intrapartum ultrasound by certified sonographers. Additional variables such as age, BMI, and gestational age were also considered.
Results:
Our findings reveal a significant relationship between HPD and the occurrence of vaginal delivery. The odds ratio was calculated as 0.60 (95% Confidence Interval: 0.42-0.88), remaining significant after adjusting for other variables.
Conclusion:
In this secondary analysis, HPD measurements via intrapartum ultrasound were found to effectively predict the likelihood of vaginal delivery. This method offers a streamlined approach for labor management without sacrificing predictive accuracy.
SD: sequence-based evolutionary distance algorithm for the Phylogenetic analysis of highly divergent proteins
Authors: Pan Xian-Ming , Cao Wei , Wu Lu-Yun , Xia Xia-Yu , Chen Xiang , Wang Zhi-Xin 
Published: September 2023

Abstract
Because of the lack of an accurate sequence-based algorithm for estimating the evolutionary distance between distant homologous protein sequences, the phylogenetic analysis problem remains unsolved. Here, we propose a sequence-based evolutionary distance algorithm termed sequence distance (SD), which innovatively incorporates site-to-site correlation within protein sequences into the distance estimation. In protein superfamilies, SD can effectively distinguish evolutionary relationships both within and between protein families, producing phylogenetic trees that closely align with those based on structural information, even with sequence identity less than 20%. SD is highly correlated with the similarity of the protein structure, and can calculate evolutionary distances for thousands of protein pairs within seconds using a single CPU, which is significantly faster than most protein structure prediction methods that demand high computational resources and long run times. The development of SD will significantly advance phylogenetics, providing researchers with a more accurate and reliable tool for exploring evolutionary relationships.
Control Design for an Exoskeleton System Based on the Human Gait
Authors: Lee Chi-Ying , Tsai I-Haur , Yen Jia-Yush , Hsu Wei-Li 
Published: September 2023

Abstract
Exoskeleton systems are wearable devices originally designed to enhance the physical abilities of humans, and subsequently for medical rehabilitation purposes. Impedance control is primarily used to achieve adaptability in exoskeleton control research. The concept of motion balance has not yet been applied to exoskeleton systems, which led us to propose a digital-twin concept, which operates in parallel with the operator. The digital twin is calculated by analyzing the dynamic characteristics of the entire human body, with the aim of determining the joint torques required to maintain balance and stability. If a discrepancy is detected between operator movements and the torques calculated using the digital twin, the system promptly provides assistance to ensure the safe operation of the exoskeleton.
This study implemented the digital twin by utilizing the MATLAB Simscape modeling tool to construct a bipedal robot model that conforms to human body proportions and simulates real human postures. The zero-moment point was used as a reference point in the model for the interaction forces between the bipedal robot and the ground. We adopted the cart-table model to simplify the gait balance control of the bipedal robot model. The controller outputs an assistive force at the position of the center of mass to maintain balance during walking. Finally, we converted the assistive force into ankle joint outputs to enhance gait stability and ensure that the waveform and numerical outputs were closer to real human data found in the literature.
A Potential Strategy against Clinical Carbapenem-Resistant Enterobacteriaceae: Antimicrobial Activity Study of Sweetener-Decorated Gold Nanoparticles in Vitro and in Vivo
Authors: Liu Haifeng , Huang Zeyu , Chen Huanchang , Zhang Ying , Yu Pinting , Hu Panjie , Zhang Xiaotuan , Cao Jianming , Zhou Tieli 
Published: September 2023

Abstract
Background
Carbapenem-resistant Enterobacteriaceae (CRE) present substantial challenges to clinical intervention, necessitating the formulation of novel antimicrobial strategies to counteract them. Nanomaterials offer a distinctive avenue for eradicating bacteria by employing mechanisms divergent from traditional antibiotic resistance pathways and exhibiting reduced susceptibility to drug resistance development. Non-caloric artificial sweeteners, commonly utilized in the food sector, such as saccharin, sucralose, acesulfame, and aspartame, possess structures amenable to nanomaterial formation. In this investigation, we synthesized gold nanoparticles decorated with non-caloric artificial sweeteners and evaluated their antimicrobial efficacy against clinical CRE strains.
Results
Among these, gold nanoparticles decorated with aspartame (ASP_Au NPs) exhibited the most potent antimicrobial effect, displaying minimum inhibitory concentrations ranging from 4 to 16 µg/mL. As a result, ASP_Au NPs were chosen for further experimentation. Elucidation of the antimicrobial mechanism unveiled that ASP_Au NPs substantially elevated bacterial reactive oxygen species (ROS) levels, which dissipated upon ROS scavenger treatment, indicating ROS accumulation within bacteria as the fundamental antimicrobial modality. Furthermore, findings from membrane potential assessments suggested that ASP_Au NPs may represent a potential antimicrobial modality via depolarization of bacterial membranes. In addition, experiments involving crystal violet demonstrated effective suppression of bacterial biofilm formation by ASP_Au NPs. Moreover, ASP_Au NPs demonstrated notable efficacy in the treatment of Galleria mellonella bacterial infection and acute abdominal infection in mice, concurrently mitigating the organism's inflammatory response. Crucially, evaluation of in vivo safety and biocompatibility established that ASP_Au NPs exhibited negligible toxicity at bactericidal concentrations.
Conclusions
Our results demonstrated that ASP_Au NPs exhibit promise as innovative antimicrobial agents against clinical CRE.
Shaped Controlled Polyindole decorated Vanadium Selenide nanosheets: A worthy approach using Hydrotrope for asymmetric supercapacitors
Authors: Vhatkar Shashikant Shivaji , Mathew Helen Treasa , Abhisek Kumar , Oraon Ramesh 
Published: September 2023

Abstract
Polyindole (PIN) has been one of the rising promising conducting polymers of this decade, attracting researchers’ attention worldwide. This can be attributed to better redox activity and physicochemical stability. Several techniques had reported synthesis of PIN in organic and aqueous media. However, it has been always reported as difficult. Challenges such as mixed morphology, irregular particle size and undesired agglomeration are among several outcomes’ researchers face. Hence, for the first time we present hydrotopically engineered chemical oxidative polymerisation of indole in the presence of Vanadium selenide (VS) in aqueous media. A hydrotrope is a compound that enhances the aqueous solubility of organic compound. The resulting nanocomposite was comprised of decorated polyindole over self-assembled 1D vanadium selenide, giving a 3D sheet like structure, as evident from FESEM studies. The results also highlighted uniform decoration of PIN over the background of VS. Besides, the physicochemical interaction between PIN and VS had been validated using Fourier transform infrared (FTIR) and XRD analysis. Furthermore, electrochemical studies through cyclic voltammetry, galvanic charging discharging techniques for the nanocomposite revealed improved specific capacitance of PV (w.r.t VS) as evidenced from the higher voltametric output current than VS. Electrochemical impedance also corroborated the superior charge transfer at lower frequencies, suggesting the real time applications of the nanocomposite. Lastly, to compliment the electrochemical performance, the nano composite was also used in fabrication of asymmetric super capacitor, which was used to illuminate LED and power a digital stopwatch to augment the conductivity and real time charge storage ability of the as synthesised nanocomposite. To the best of our knowledge, synthesis of PV nano composite using hydrotrope – tetra n-octyl ammonium bromide in aqueous medium can be a promising electrode material for fabrication of super capacitor, resulting in a synergistic enhancement of vanadium selenide using PIN.
Geochemistry of the Guadalupian - Lopingian Carbonate Rocks from the NE Sichuan Basin, China: Implications for Paleo-oceanic Environment and Provenance
Authors: Yao Shengyang , Mou Chuanlong , Zhou Gang , Wang Qiyu , Wang Xiuping , Ren Peng , Zan Bowen 
Published: September 2023

Abstract
The Dongwu Movement (including the eruption of the Emeishan Large Igneous Province (ELIP) ) , as the last part of the Hercynian cycle in the Yangtze region is an essential event between the Guadalupian and Lopingian, which has significant implications for the Paleo-oceanic environment and Paleoclimate of the area. To study the changes in the sedimentary environment in the Guadalupian and Lopingian, the Zhenba section was selected to analyze trace elements and rare earth elements. Trace elements and rare earth elements indicate that in the Guadalupian, the limestone samples had prominent typical shallow-water seawater deposition characteristics and were less affected by terrigenous detritus, which was an arid oxidation environment (Sr/Cu ranges from 4 to 1381; Rb/Sr value is low; δCe<1, Ceanom<-0.1; Er/Nd ranges from 0.1 to 0.27; Y/Ho ranges from 44 to 72), while in the Lopingian, the limestone samples were more affected by terrigenous detritus, which was a humid climate with the weak oxidation-reduction environment (Sr/Cu ranges from 1 to 656; Rb/Sr value is high; δCe tends to 1, Ceanom greater than and close to -0.1; Er/Nd<0.1; Y/Ho ranges from 26 to 44). The geochemical diagrams of TiO2-Al2O3, Al2O3-REE, La-Th-Sc, Th-Co-Zr/10, Th-Sc-Zr/10 and 87Sr/ 86Sr of the sample indicate that the terrigenous detrites of the sample should mainly come from the South Qinling active continental margin, rather than the weathering of Emeishan basalt. Acid bentonite should come from the Paleo-Tethys island arc or the island arc formed by the subduction of the South China Plate to the North China Plate, rather than ELIP. These evidences support the view that the North China Plate may have collided with the South China Plate in the middle to late Wujiaping.
Merger to monopoly in a vertically differentiated duopoly with positional effects
Authors: Skartados Panagiotis , Zacharias Eleftherios 
Published: September 2023

Abstract
We provide an alternative behavioral approach to the well-known argument that a merger to monopoly is desirable only when it is accommodated by a (supply-side) technology transfer and cost reduction. When consumers are subject to positional effects, like status or envy, there are instances where a merger to monopoly may be welfare-enhancing due to a (demand-side) utility-increasing argument.
JEL Classification: L11; D11; D42.
Risk Factors for Pyogenic Liver Abscess Caused by Klebsiella pneumoniae: A Retrospective Study
Authors: Lyu Yunxiao , Wang Bin 
Published: September 2023

Abstract
Background: Pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae can vary in severity, and several risk factors for the development of PLA have been implicated. However, few studies to date have explored these risk factors.
Methods: In this retrospective study spanning from February 2013 to December 2022, we investigated patients with PLA caused by K. pneumoniae infection. Using logistic regression analysis, we sought to identify factors associated with positive blood culture, septic shock, and intensive care unit (ICU) admission.
Results: The study involved 200 patients. We found that an elevated procalcitonin (PCT) level (odds ratio [OR]: 1.02, p = 0.03), higher glucose (GLU) level (OR: 1.13, p = 0.03), and lower total cholesterol (TC) level (OR: 0.43, p = 0.01) were associated with a higher likelihood of positive blood bacteriological culture. Additionally, an increased PCT level (OR: 1.03, p = 0.02) and lower TC level (OR: 0.25, p < 0.01) were associated with an elevated risk of septic shock. Furthermore, a higher PCT level (OR: 1.04, p < 0.01) was associated with a higher probability of ICU admission.
Conclusion: In patients with PLA caused by K. pneumoniae, the PCT, GLU, and TC levels were found to be associated with positive blood culture, septic shock, and ICU admission.
Kink Waves in Twisted and Expanding Magnetic Tubes
Authors: Ruderman M. S. , Petrukhin N. S. , Petrukhin N.S. 
Published: September 2023

Abstract
We study kink and fluting waves in expanding and twisted magnetic-flux tubes. We use the thin-tube and zero-beta plasma approximations. The equilibrium magnetic field is force-free with a constant proportionality coefficient between the electrical current and magnetic field. We derive the equation governing the kink and fluting wave in a tube. Using this equation we study the propagation of kink waves in a particular case of a magnetic tube homogeneous in the axial direction. We show that while there is only one propagating kink wave with the phase speed equal to the kink speed in an untwisted tube, in a twisted tube there are two wave modes, accelerated and decelerated. The phase speed of the accelerated wave exceeds the kink speed, while the phase speed of the decelerated wave is less than the kink speed. We also show that the standing modes are defined by the same eigenvalue problem as that in the case of an untwisted tube. Hence, the frequencies of the standing wave modes are not affected by the twist. This implies that the seismological results based on the observation of the standing wave mode frequencies remain valid when the twist is taken into account. The only effect of twist is the variation of the direction of polarisation of the coronal magnetic loop displacement along the loop. As a result an apparent node can be detected near the loop apex if only one component of the loop displacement is observed. This can lead to a wrong conclusion that the observed coronal loop kink oscillation was the first overtone while in fact it was the fundamental mode.