bluuebunny/crossref_metadata_2025_split huggingface dataset:
Some Applications of Fixed Point Results for Monotone Multi-Valued and Integral Type Contractive Mappings.
Authors: NASSAR NASSAR AIMAN MAJID NASSAR , JUMAILI ALAA. M. F. AL. JUMAILI AL. , ZHEN ZHEN CHUAN NG , SEE SEE KEONG LEE 
Published: March 2023

Abstract
The motivation of the present paper is to introduce and establish some of new fixed point results for monotone Multi-valued functions in partially ordered complete D*-Metric spaces in the setting of , where the partial ordered set is obtained via a pair of functions Moreover, several of the existence and uniqueness of coupled fixed point theorems of mappings satisfying contractive conditions have been investigated and verified in the setting of partially ordered complete by using the concept of integrally type contractions with respect to partially ordered . Furthermore, we present appropriate examples as an application for our main results. Our results generalize and complement different well-known comparable results from the current literature.
2000 Mathematics Subject Classification. Primary: 47H09 and 47H10; Secondary: 54H25.
Genome-wide transcriptome and physiological analyses provide new insights into cadmium tolerance of tomato seedlings
Authors: Yuqiong Li , Quanwu Liang , Ge Song , Wu Jinfeng , Haihua Wang , Mingli Yan , Zhang Jihong 
Published: March 2023

Abstract
In China, cadmium (Cd) contamination has turned into a primary environmental concerns in agricultural soils. This research surveyed the molecular mechanism of biochemical and physiological in response to Cd stress in tomato plants. Cadmium treatment prominently restrained tomato root growth (by 43.46%), and stimulated their antioxidant enzyme activities (POD and CAT). Cadmium treatment reduced their dry weight of shoot and root at day 7, by 40.42% and 60.40%, respectively. During the entire processing period, total chlorophyll contents were decreased and the malondialdehyde (MDA) content increased. A comparative transcriptome (RNA-Seq) was assembled de novo and differentially expressed genes (DEGs) were surveyed among 7-day-old tomato plants with or without cadmium ion treatment for 24 h. 18,883 unigenes in total were grouped into 51 Gene Ontology (GO) categories and 89 Kyoto Encyclopedia of Genes and Genomes terms (KEGG). There were 1,716 differentially expressed genes (DEGs), 559 down- and 1157 up-regulated genes. Go term enrichment analysis revealed that multiple phytohormone-related signaling pathway were significantly enriched in DEGs. Most genes involved in lignin biosynthesis pathway were up-regulated, for instance, COMT and CCOMT. Cd2+ is absorbed into tomato root cells to generate ROS and gives rise to oxidative stress. The essential hormones biosynthesis such as ethylene, IAA and JA should be stimulated to induce the activation of signal proteins. Our results provide the basis for further understanding of Cd tolerance mechanisms in plants.
Cryptic diversity of Eviota (Teleostei: Gobiidae) and their habitat use in the shallow waters of Okinawa Island
Authors: Hanahara Nozomi 
Published: March 2023

Abstract

Eviota, known as dwarf gobies, is a diverse genus of marine fishes comprising more than 120 species found throughout the Indo-Pacific Ocean. A previous study has suggested that morphologically similar cryptic species of Eviotamay exist and that the species diversity may be significantly underestimated. This study evaluated the diversity of Eviotaspecies in three habitat types (tidal flats, reef flats, and moats) in the shallow waters (0–1 m in depth at low tide) of Okinawa Islandusing morphological characteristics and molecular phylogenetic analysis. Eleven morphospecies were classified into 17 molecular optical units(MOTUs), and cryptic species for which speciation may have occurred relatively recently were detected in the morphospecies Eviota abax, Eviota japonica, Eviota queenslandica, and Eviota prasina. Most MOTUs exhibited only one habitat use, whereas three MOTUs were found in multiple habitats. Among each cryptic Eviota species, both habitat segregation and habitat overlaps were found. Therefore, speciation in Eviota may occur without habitat segregation, and multiple other factors should be considered regarding speciation in Eviota.
Cohort Profile: Beijing Healthy Aging Cohort(BHACS)
Authors: Liu Miao , Yang Junhan , Wang Chunxiu , Yang Shanshan , Wang Jianhua , Hou Chengbei , Wang Shengshu , Li Xiaoying , Li Fang , Yang Hongbing , Li Haowei , Liu Shaohua , Chen Shimin , Hu Shimin , Li Xuehang , Li Zhiqiang , Li Rongrong , Li Huaihao , Bao Yinghui , Shi Yueting , Tang Zhe , Fang Xianghua , He Yao 
Published: March 2023

Abstract
BHACS was established to fill the lack of a large representative cohort of the elderly based on general populations and was designed to evaluate the prevalence, incidence, and natural history of cognitive decline, functional disability, and conventional vascular risk factors. The objectives were to determine the evolution of those diseases by estimating rates and impact factors of progression and reversion to adverse outcomes including dementia, cardiovascular events, cancer, and all-cause death. Therefore, it can provide evidence to help policy-makers develop better policies to promote healthy aging in China.
BHACS was formed by three cohorts in Beijing with a total population of 11 235 (6281 in urban, 4954 in rural), the baseline survey time and follow-up time differed between the three. BLSA was followed up in 2014 with the baseline survey completed in 2009; CCHS-Beijing was followed up twice in 2015-2016 and 2018-2019 as its baseline survey was performed in 2013-2015; BECHCS was followed up every two or three years with the baseline investigation completed in 2010-2014.
Data were collected using questionnaires, physical measurements, and laboratory analysis. Topics of BHACS include numerous physical and mental health indicators, living habits, and personal, familial, and socio-economic health determinants. There is no immediate plan to make the cohort data freely available in the public domain, specific proposals for further collaboration are welcome.
Improve the efficiency and accuracy of ophthalmologists' clinical decision-making based on AI technology
Authors: Guo Yingxuan , Huang Changke , Sheng Yaying , Zhang Wenjie , Ye Xin , Lian Hengli , Xu Jiahao , Chen Yiqi 
Published: March 2023

Abstract
Objective
This article proposes a named entity recognition model for electronic medical records in ophthalmology that integrates professional vocabulary information. The aim is to achieve structured processing of important clinical decision-making data and to develop a clinical aided diagnosis platform based on this. The effectiveness of this platform in improving the efficiency and accuracy of ophthalmologists in clinical diagnosis decision-making was validated.
Methods
Based on the best entity recognition model, we constructed the aided diagnosis platform. By conducting a controlled experiment that compared the use of the platform by doctors with different levels of experience, we analyzed the effectiveness of the aided diagnosis platform in improving diagnosis decision-making efficiency and accuracy.
Results
The SoftLexicon-Glove-Word2vec model had the highest F1 score at 93.02%. Both junior and senior doctors showed significant improvement in diagnosis efficiency and accuracy (P < 0.05) when using the platform. Regardless of whether the aided diagnosis platform was used or not, there were significant differences in diagnosis decision-making efficiency and accuracy between junior and senior doctors (P < 0.05).
Conclusion
The use of artificial intelligence technology to construct the aided diagnosis platform for fundus diseases can effectively improve the clinical decision-making ability of junior doctors, and improve the diagnosis efficiency and accuracy.
Web Accessibility in the Field of Social Services and Benefits in Romania
Authors: Marin Anca Monica , Popa Liliana 
Published: March 2023

Abstract
This paper examines the current situation in Romania in terms of web accessibility provided by two key institutions in the field of administering social services and benefits in Romania – County Directorates of Social Work and Child Protection (DGASPC) as well as County Pensions Houses (CJP). As the pandemic context further accelerated development of e-government worldwide, there is a strong need to ensure information and communication accessibility for persons with disabilities and persons with functional limitations in general. The assessment grid is represented by the Web Content Accessibility Guidelines (WCAG) 2.1 requirements and techniques, mainly regarding Level A, minimum level of conformance. Results underline significant discrepancies on implementing various accessibility characteristics among similar institutional bodies and the needs to take further steps on improved accessibility. The study adds knowledge on the larger topic of digital inclusion, as a contributor to enhanced social inclusion. It also contributes to the international debate on web accessibility evaluation and developing accessibility in web design, especially in the case of public authorities who have under their responsibility services directly addressed to persons with disabilities or to older persons with visual or hearing impairments.
The synzootic potential of common epidemics in chamois populations
Authors: Garrido-Amaro Cristina , Jolles Anna , Velarde Roser , López-Olvera Jorge Ramón , Serrano Emmanuel 
Published: March 2023

Abstract
Southern chamois (Rupicapra pyrenaica) is a medium-sized and gregarious mountain ungulate with populations affected by periodic outbreaks of border disease virus (BD), infectious keratoconjunctivitis (IKC), and sarcoptic mange (SM). Even though the impact of each disease on chamois populations has been described in detail, there is a lack of information about the potential impact of concomitant epidemics and the synzootic potential (co-occurring enzootic or epizootic processes producing worse health outcomes in wildlife) on chamois populations. Furthermore, whether a specific order of apparition of epidemics is more or less harmful for the host population is practically unknown not only for chamois but also for most mammal populations. Using a population viability analysis (PVA), we studied the consequences of multiple disease outbreaks with synzootic potential on growth rates and probabilities of extinction of virtual populations exposed to hard winters, density dependence and co-occurring BD, IKC and SM outbreaks. Such infections are not under cross-immunity nor density-dependent processes and thus are supposed to affect population demography independently. Heavy snowfalls are also likely to occur in our simulated populations. Our simulations showed that a second outbreak, even caused by a low virulent pathogen, causes an increase in the probability of extinction of the host population with regard to the first outbreak. IKC-BD and SM-BD affected populations had a higher risk of becoming extinct in 50 years confirming the extra risk of multiple outbreaks on the viability of the affected populations.
The EuFe2As2 magnetic state peculiarities as revealed by ESR
Authors: Talanov Yurii , Gimazov Ilnur , Zaripov Ruslan , Pervakov Kirill , Vlasenko Vladimir , Pudalov Vladimir , Teitel'baum Gregory 
Published: March 2023

Abstract
The magnetic state of the EuFe2As2 single crystal was investigated by means of electron spin resonance (ESR). ESR spectra of europium ions were obtained in the temperature range from 250 K to 4 K. To study the anisotropy, the in-plane angular dependences were obtained at temperatures of 15 K upon rotating a crystal around c-axis. The data analysis has shown that EuFe2As2 is an antiferromagnet with an easy anisotropy plane. Moreover, the second-order easy magnetization axis is observed for each of the two types of magnetic domains connected to structure twins arising from the tetragonal-to-orthorhombic crystal lattice transition.
Genome-wide detection of CNV regions between Anqing six-end-white and Duroc pigs
Authors: Qian Rong , Xie Fei , Zhang Wei , Dong Wei , Kong JuanJuan , Zhou Xueli , Wang Chonglong , Li Xiaojin 
Published: March 2023

Abstract
Anqing six-end-white pig is a native breed in Anhui Province. The pigs have the disadvantages of a slow growth rate, low proportion of lean meat, and thick back fat, but feature the advantages of strong stress resistance and excellent meat quality. Duroc pig is an introduced pig breed with a fast growth rate and high proportion of lean meat. With the latter breed featuring superior growth characteristics but inferior meat quality traits, the underlying molecular mechanism that causes these phenotypic differences between Chinese and foreign pigs is still unclear. In this study, copy number variation(CNV) detection was performed using the re-sequencing data of Anqing Six-end-white pigs and Duroc pigs, A total of 65,701 CNVs were obtained. After merging the CNVs with overlapping genomic positions, 881 CNV regions (CNVRs) were obtained. Based on the obtained CNVR information combined with their positions on the 18 chromosomes, a whole-genome map of the pig CNVs was drawn. GO analysis of the genes in the CNVRs showed that they were primarily involved in the cellular processes of proliferation, differentiation, and adhesion, and primarily involved in the biological processes of fat metabolism, reproductive traits, and immune processes. The difference analysis of the CNVs between the Chinese and foreign pig breeds showed that the CNV of the Anqing six-end-white pig genome was higher than that of the introduced pig breed Duroc. Six genes related to fat metabolism, reproductive performance, and stress resistance were found in genome-wide CNVRs (DPF3, LEPR, MAP2K6, PPARA, TRAF6, NLRP4).
Effect of Pantanal Fire Events on the Secondary Metabolism of Plants
Authors: Siqueira Camila Sório , Santos Vanessa Samúdio dos , Júnior Geraldo Alves Damasceno , Carollo Carlos Alexandre 
Published: March 2023

Abstract

We investigated the effects of fire on the secondary metabolites ofRhamnidium elaeocarpumin the Pantanal region. We analyzed the total phenol and tannin content of individuals from four different sampling groups and used LC-MS metabolomics techniques to observe the metabolites present in the samples and the thermogravimetric behavior of the species. Our findings suggest that recent fires did not significantly affect the species' phenolic metabolism, except for specimens affected by the 2020 megafire, which exhibited a decline in compounds due to leaching. The data suggests that recent fire incidents did not impact the phenolic metabolism of the species, and the high levels indicate that the species has a biochemical tolerance to the stress caused by seasonal fires. Metabolomic profiles showed intense biosynthesis of proanthocyanidin oligomers, which protect against oxidative stress and post-fire environmental disturbances. The results of the thermogravimetric behavior showed the species' thermotolerance and intrinsic relationship with secondary compounds. Overall, our study advanced our understanding of the impact of fire on woody species' metabolism. However, distinguishing whether chemical traits are an adaptive feature or a response to surrounding environmental factors presents a challenge.
Morphological and Phylogenetic Analyses Reveal a New Species of Anthracophyllum (Omphalotaceae, Agaricales) in Zhejiang Province, China
Authors: Yang Wen-Juan , Xu Miao , Zhang Jing , Zhou Fan , Le Zhi-Fang , Tong Wen-Jun , Song Hai-Yan , Jin Zhuo-Han , Cheng Qiu-Ge , Zhou Jian-Ping , Gao Yang , Zhai Zhi-Jun , Hu Hai-Jing , Chen Ming-Hui , Yin Hua , Wang Jiang , Hu Dian-Ming 
Published: March 2023

Abstract

During the investigations of macrofungi resources in Zhejiang Province, China, an interesting wood rot fungus was collected. Based on morphological and molecular phylogenetic studies, it was described as a new species Anthracophyllum sinense. A. sinense is characterized by its sessile, charcoal black and pleurotoid pileus; sparse, occasionally branches lamellae; oval basidiospores measuring (8–)9–11.2–13(–14) µm × (5–)6–6.6–8(–9) µm, with obvious spore tips; clavate basidia with obvious sterigmata; and non-heteromorphous cystidium. A. sinense established a separate lineage that was similar to A. archeri and A. lateritium in the phylogenetic tree.
A Context-Aware on-board Intrusion Detection System
Authors: Micale Davide , Matteucci Ilaria , Fenzl Florian , Rieke Roland , Patanè Giuseppe 
Published: March 2023

Abstract
Modern vehicles are becoming increasingly attractive from the perspective of possible intruders. The main reasons are twofold: modern vehicles are now connected to the outside world via Wi-Fi, Bluetooth, and mobile connection, such as LTE and 5G, and the increasing complexity of the on-board software enlarges the attack surface. In this article, we introduce CAHOOTv2, a context-sensitive intrusion detection system (IDS) that uses the vehicle’s sensors to determine driver habits and gather information about the environment to detect intruders. We use hyperparameter tuning to increase detection accuracy. To demonstrate the validity of the algorithm, we collected driving data from both an Artificial Intelligence (AI) and 39 humans. We include the AI driver to demonstrate that CAHOOTv2 is able to detect intrusions when the driver is both a human or an AI. The dataset is obtained using a modified version of MetaDrive simulator where we consider also the presence of an intruder able to perform the following types of intrusions: denial of service, replay, spoofing, additive and selective attacks. We make several experiments showing the benefits of hyperparameters tuning. The results of CAHOOTv2 are promising on detection of intrusions.
Global Well-Posedness for Eddy-Mean Vorticity Equations on T2
Authors: Cacchio' Yuri 
Published: March 2023

Abstract
We consider the two-dimensional, β-plane, eddy-mean vorticity equations for an incompressible flow, where the zonally averaged flow varies on scales much larger than the perturbation. We prove globalexistence and uniqueness of the solution to the equations on periodic settings.
Mathematics Subject Classification (2010). 35Q86.
The interlayer shear stress in a double-layered tube of finite length with cylindrical orthotropy and radial inhomogeneity subjected to end torsional loads
Authors: Wang Chung-Hao 
Published: March 2023

Abstract
The elastic torsion problem for a circular tube which contains two perfectly bounded layers of finite length is analyzed herein with the emphasis placed on the interlayer shear stress at the bonded interface. The material property for each layer is considered both cylindrically orthotropic and radially inhomogeneous. Analytical solutions for the whole structure are derived via a unified methodology and the shear stress on the bonding interface is readily available and thoroughly investigated. The results reveal that the interlayer shear stress near the end will arise when the end torsional load differs from the associated Saint Venant torsion. And a particular material property relationship existing between two layers and under a particular end loads is found that the end effects inducing the interlayer shear stress can be fully eliminated. Concluding from the investigations analyzed using the derived general solutions, the distributions and the variation trends of the interlayer shear stress at the bonding interface subject to the variations of the main controlled parameters are discussed and summarized.
DNA response and repair gene mutations as a signature for pembrolizumab response in never-smoker non-small lung cancer: real word approach and patient similarity network analysis
Authors: Filetti Marco , Occhipinti Mario , Cirillo Alessio , Scirocchi Fabio , Ugolini Alessio , Giusti Raffaele , Lombardi Pasquale , Daniele Gennaro , Botticelli Andrea , Russo Giuseppe Lo , Braud Filippo Maria , Marchetti Paolo , Nuti Marianna , Ferretti Elisabetta , Farina Lorenzo , Rughetti Aurelia , Petti Manuela 
Published: March 2023

Abstract
Purpose
Single-agent immune checkpoint inhibitor (IO) therapy is the standard of care for non-oncogene addicted advanced non-small cell lung cancer (aNSCLC) with PD-L1 ≥ 50%. High tumor mutation burden (H-TMB) is a notable biomarker for IO response. Smoking-induced harm generates H-TMB in smoking aNSCLC patients (S-pts), whereas never-smoking patients (NS-pts) usually have low TMB and are IO-unresponsive. However, NS-pts with H-TMB have not been well molecularly characterized.
Experimental design
Clinical data of 142 aNSCLC patients with PD-L1 ≥ 50% treated with first-line pembrolizumab were retrospectively collected. Next-generation sequencing was performed using the FoundationOne®CDx assay to correlate genomic alterations with clinical characteristics and response outcomes. Detected mutations were classified into eleven main pathways: cell cycle, Hippo, Myc, Notch, oxidative stress/Nrf2, PI3K, RTK/RAS/MAP, TGF-b, p53, b-catenin/Wnt, and DDR. Enrichment analysis was performed on pathways with at least one mutation per patient to characterize patient subgroups based on mutated pathways. Moreover, to further investigate the molecular characterization of patients’ subgroups, we built and analyzed the patient similarity network exploiting the mutational profile to compute the pairwise similarity between patients.
Results
There were 111 S-pts and 31 NS-pts; S-pts had higher TMB (median TMB: 8 vs. 4 Mut/Mb). However, 11 NS-pts had high TMB (median TMB: 16.39 Mut/Mb) and were significantly enriched in b-catenin/Wnt and DDR pathway mutations (p-values=0.0027 and 0.0014, respectively) compared to others and H-TMB/S-pts. Using publicly available molecular characterization data (of 853 NSCLC patients from 2 randomized controlled trials), DDR pathway mutations were confirmed to be enriched in NS-pts with H-TMB. In the real world cohort the subgroup of H-TMB/NS-pts with DDR pathway mutation showed better IO response and survival. Moreover, the similarity network analysis of the NS-pts revealed the presence of one subgroup characterized by high TMB, improved OS and a prevalence of DDR pathway mutations.
Conclusions
DDR signature has a potential role as additional generator of H-TMB in NS-pts. This subgroup of IO-responsive NS-pts may have better prognosis.