bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photometric and spectroscopic properties of the eclipsing system V864 Monocerotis
Authors: Park Jang-Ho , Lee Jae Woo , Hong Kyeongsoo 
Published: September 2023

Abstract
We present the orbital period variability and evolutionary status of the W UMa-type binary system V864 Mon from accurately measured fundamental parameters. New BV photometric observations of this system were performed in 2019 January and 2022 January, and the first high-resolution spectroscopic observations were carried out on three nights between 2019 January and March. A total of 29 times of minimum light were collected to examine the behavior of the orbital period. Our analysis of these timings indicates a continuous period increase at a rate of +2.62 × 10−7 d yr−1 over the past 20 years, which can be interpreted as a mass transfer from the less massive primary to the secondary component with a rate of 1.22 × 10−7 M⊙ yr−1. We measured the radial velocities (RVs) for both components, and determined the effective temperature and projected rotational velocity of the more massive secondary star to be Teff,2 = 5450 ± 94 K and v2sin i = 192 ± 40 km s−1, respectively, from the comparison of the observed spectrum at the primary minimum and the theoretical models. The individual masses and radii of both components were determined from a simultaneous analysis of the light and RV curves, which are M1 = 0.34 ± 0.02 M⊙, R1 = 0.69 ± 0.01 R⊙, and M2 = 1.06 ± 0.04 M⊙, R2 = 1.16 ± 0.02 R⊙, respectively. Our results indicate that V864 Mon is a W-subtype of W UMa stars with time-varying spot activity. The positions in the mass-luminosity and mass-radius diagrams indicate that the secondary star belongs to the main-sequence region, while the hotter primary is located beyond the terminal-age main sequence.
Research Agenda for Physical Therapy From the American Physical Therapy Association
Authors: Stevens-Lapsley Jennifer , Hicks Gregory E , Zimney Kory , Slaven Emily J , Manal Tara Jo , Jeffries Lynn M 
Published: September 2023

Abstract

Research agendas play an important role in directing scholarly inquiry in a field. The Research Agenda for Physical Therapy From the American Physical Therapy Association (APTA) outlines research priorities that are vital to advancing physical therapist practice and the profession. The development of the research agenda included multiple iterative steps and feedback from stakeholders. A research agenda subgroup (n = 6) of the APTA Scientific and Practice Affairs Committee (SPAC), with APTA staff support, gathered information on existing research agendas, developed draft priority descriptions, and gathered feedback via surveys. The subgroup first conducted an environmental scan of the research agendas in the physical therapy and rehabilitation fields. To gather information about research priorities, APTA’s Technology and Organizational Performance department distributed a survey to 3 samples. APTA staff organized the feedback, and SPAC edited and synthesized a draft agenda. This draft was sent out in survey form to the original samples and to members of the APTA Academy of Research. Concurrently, a repeat environmental scan was conducted. A final draft of the research agenda was sent for final review to a smaller cohort (n = 95) that included content experts in each of the main categories of the agenda as identified by the APTA Academy of Research. The SPAC research agenda subgroup reviewed and incorporated the information into the final draft. The final research agenda includes priorities in topical areas (population health, mechanistic research, clinical research, education/professional development research, health services research, and workforce development) identified as key in the evolution of our profession.

Impact
The Research Agenda for Physical Therapy From APTA identifies research priorities within the profession vital to advancing the practice and profession of physical therapy. The research agenda has 6 key areas of focus: population health research, mechanistic research, clinical research, education and professional development research, health services research, and workforce research. Researchers, funding agencies, and public policy makers can use the research agenda to concentrate research efforts around these areas.
Tetrahedral framework nucleic acids enhance the chondrogenic potential of human umbilical cord mesenchymal stem cells via the PI3K/AKT axis
Authors: Fu Liwei , Li Pinxue , Wu Jiang , Zheng Yazhe , Ning Chao , Liao Zhiyao , Yuan Xun , Ding Zhengang , Zhang Zhichao , Sui Xiang , Shi Sirong , Liu Shuyun , Guo Quanyi 
Published: September 2023

Abstract
The field of regenerative medicine faces a notable challenge in terms of the regeneration of articular cartilage. Without proper treatment, it can lead to osteoarthritis. Based on the research findings, human umbilical cord mesenchymal stem cells (hUMSCs) are considered an excellent choice for regenerating cartilage. However, there is still a lack of suitable biomaterials to control their ability to self-renew and differentiate. To address this issue, in this study using tetrahedral framework nucleic acids (tFNAs) as a new method in an in vitro culture setting to manage the behaviour of hUMSCs was proposed. Then, the influence of tFNAs on hUMSC proliferation, migration and chondrogenic differentiation was explored by combining bioinformatics methods. In addition, a variety of molecular biology techniques have been used to investigate deep molecular mechanisms. Relevant results demonstrated that tFNAs can affect the transcriptome and multiple signalling pathways of hUMSCs, among which the PI3K/Akt pathway is significantly activated. Furthermore, tFNAs can regulate the expression levels of multiple proteins (GSK3β, RhoA and mTOR) downstream of the PI3K-Akt axis to further enhance cell proliferation, migration and hUMSC chondrogenic differentiation. tFNAs provide new insight into enhancing the chondrogenic potential of hUMSCs, which exhibits promising potential for future utilization within the domains of AC regeneration and clinical treatment.
Effects of allergen immunotherapy on follicular regulatory T cells
Authors: Sun Shi-Ran , Yao Yin , Liu Zheng 
Published: September 2023

Purpose of review
Emerging evidence indicating that the dysfunction of T follicular regulatory (TFR) cells contributes to excessive immunoglobulin E (IgE) production and the development of allergic diseases. Conversely, allergen immunotherapy (AIT) modulates TFR cells abundance and function to promote immune tolerance. This review focus on the role of TFR cells in allergic diseases and AIT, with the objective of providing novel insights into the mechanisms underlying immune tolerance of AIT and proposing the potential targeting of TFR cells in the context of allergic diseases.

Recent findings
Numerous studies have consistently demonstrated that TFR cells play a pivotal role in the inhibition of class switch recombination to IgE in both humans and specific murine models. This suppression is attributed to the actions of neuritin and IL-10 secreted by TFR cells, which exert direct and indirect effects on B cells. In patients with allergic rhinitis, reduced frequencies of circulating or tonsillar TFR cells have been reported, along with impaired functionality in suppressing IgE production. AIT, whether administered subcutaneously or sublingually, reinstates the frequency and functionality of TFR cells in allergic rhinitis patients, accompanied by changes of the chromatin accessibility of TFR cells. The increase in TFR cell frequency following AIT is associated with the amelioration of clinical symptoms.

Summary
TFR cells exert an inhibitory effect on IgE production and demonstrate a correlation with the clinical efficacy of AIT in patients with allergic rhinitis, suggesting TFR cells hold promise as a therapeutic target for allergic diseases and potential biomarker for AIT.
Force Profile as Surgeon-Specific Signature
Authors: Baghdadi Amir , Guo Eddie , Lama Sanju , Singh Rahul , Chow Michael , Sutherland Garnette R. 
Published: September 2023

Objective:
To investigate the notion that a surgeon’s force profile can be the signature of their identity and performance.

Summary background data:
Surgeon performance in the operating room is an understudied topic. The advent of deep learning methods paired with a sensorized surgical device presents an opportunity to incorporate quantitative insight into surgical performance and processes. Using a device called the SmartForceps System and through automated analytics, we have previously reported surgeon force profile, surgical skill, and task classification. However, an investigation of whether an individual surgeon can be identified by surgical technique has yet to be studied.

Methods:
In this study, we investigate multiple neural network architectures to identify the surgeon associated with their time-series tool-tissue forces using bipolar forceps data. The surgeon associated with each 10-second window of force data was labeled, and the data were randomly split into 80% for model training and validation (10% validation) and 20% for testing. Data imbalance was mitigated through subsampling from more populated classes with a random size adjustment based on 0.1% of sample counts in the respective class. An exploratory analysis of force segments was performed to investigate underlying patterns differentiating individual surgical techniques.

Results:
In a dataset of 2819 ten-second time segments from 89 neurosurgical cases, the best-performing model achieved a micro-average area under the curve of 0.97, a testing F1-score of 0.82, a sensitivity of 82%, and a precision of 82%. This model was a time-series ResNet model to extract features from the time-series data followed by a linearized output into the XGBoost algorithm. Furthermore, we found that convolutional neural networks outperformed long short-term memory networks in performance and speed. Using a weighted average approach, an ensemble model was able to identify an expert surgeon with 83.8% accuracy using a validation dataset.

Conclusions:
Our results demonstrate that each surgeon has a unique force profile amenable to identification using deep learning methods. We anticipate our models will enable a quantitative framework to provide bespoke feedback to surgeons and to track their skill progression longitudinally. Furthermore, the ability to recognize individual surgeons introduces the mechanism of correlating outcome to surgeon performance.
Determinants of Outcome with Reoperative Surgery for Pseudomyxoma Peritonei in 186 Patients
Authors: Sugarbaker Paul H. , Chang David 
Published: September 2023

Objective:
To describe the long-term survival and clinical- and treatment-related variables that determine the outcome of repeat cytoreductive surgery (CRS) for mucinous appendiceal neoplasms with peritoneal dissemination.

Summary Background:
After patients with peritoneal dissemination of an appendiceal mucinous neoplasm have a CRS, disease progression may require secondary cytoreductive surgery (SCRS) and other treatments performed in a timely manner to prolong survival and help preserve an optimal quality of life.

Methods:
The clinical- and treatment-related variables associated with the index CRS and the SCRS were statistically assessed for their impact on survival.

Results:
One hundred eighty-six of 687 complete CRS patients (27.1%) had SCRS. The median follow-up was 10 years and the median survival was 12 years. There were 95 males (51%) and the median age was 45.0 years. Survival benefit was associated with the index CRS by use of early postoperative intraperitoneal chemotherapy (EPIC) with 5-fluorouracil [Hazard ratio (HR), 0.4; P = 0.0004]. Also, survival of low-grade mucinous appendiceal neoplasms versus mucinous appendiceal adenocarcinoma (HR, 2.8; P < 0.0001) was improved. The interval between index CRS and SCRS was significant at ≤12 months versus 12–36 months versus >36 months (P < 0.0001). Change in peritoneal cancer index and disease distribution as focal or diffuse was significant by univariant and multivariant analyses.

Conclusions:
If the CRS was complete, the use of EPIC 5-fluorouracil, the interval between the index CRS and the SCRS, the histologic grade of the mucinous neoplasm, and the extent of recurrent disease were prognostic variables that should be used to help select patients for SCRS.
History and Evolution of Hip Design to Decrease Failure
Authors: Russell Thomas A. , Klima Matthew L. 
Published: September 2023

Summary:
The evolution of fracture fixation designs over the past 100 years is coupled with incredible advances in materials and manufacturing technology. Failures are unavoidable and should be evaluated from the perspective of refining our technology and technique to improve patient outcomes. Failure after intramedullary fixation of hip fractures is multifactorial with contributions from an unsuccessful surgery, some preventable, some unavoidable, and rarely, design and manufacturing errors. However, whenever implants are disseminated to large population groups with variable individual anatomy, physiology, and associated comorbidities, unexpected and unpredicted weaknesses in the design and surgical technique will be discovered. Surgeons have multiple choices for nail selection with specific and critical technical requirements. The surgeon should evaluate each patient individually and determine the treatment based on patient anatomy and morphology of the fracture. The surgical approach should be modified over time after deciding how best to improve surgical treatment based on the current scientific studies.
Pertrochanteric Nonunion: When and Why to Consider a Medullary Implant
Authors: Githens Michael 
Published: September 2023

Summary:
Pertrochanteric nonunion management is a technically challenging problem. When repair is undertaken rather than conversion arthroplasty, successful treatment revolves around accurate deformity correction, preservation of vascularity, and stable durable fixation. The decision to use an extramedullary or intramedullary implant should be influenced by nonunion-specific characteristics and patient-related conditions. Failure to understand these nuances when selecting an implant strategy often results in treatment failure. The primary purpose of this article was to discuss these variables and delineate when an intramedullary implant should be considered for treatment of a pertrochanteric nonunion. The secondary purpose was to describe the author's preferred surgical technique for implant-driven deformity correction and compression when choosing an intramedullary nail.
Residency Training Pathways of Program Directors and Chiefs/Chairs in Plastic Surgery
Authors: Lentskevich Marina A. , Reddy Narainsai K. , Yau Alice , Gosain Arun K. 
Published: September 2023

Background:
Medical students interested in plastic surgery may become discouraged by barriers to career development during residency training. This study surveyed plastic surgery program directors (PDs) and chiefs/chairs to highlight the pathway followed by academic leaders in these positions.

Methods:
A self-administered anonymous survey was sent to a list of 189 PDs and chiefs/chairs identified via plastic surgery residency programs’ websites. Chi-squared tests assessed answer distributions.

Results:
Of the 189 recipients (25.9%), 49 completed the survey. Respondents’ medical school graduation range was 1973–2009. Seventeen respondents entered a plastic surgery residency directly after medical school, and 32 began in another specialty. Comparison between these two groups showed no significant differences in preference rank of their program (P = 0.671). A total of 18 respondents conducted an academic enrichment year, but timing of this year differed significantly based on the initial specialty match (P = 0.012). There was no significant perceived difficulty in gaining recognition by gender (P = 0.107) or race (P = 0.125). Six respondents did not match into the specialty of first choice; five did not complete their initial residency programs; three did not match into plastic surgery at first attempt.

Conclusions:
Information on residency training pathways and barriers to career development of current academic leaders will improve transparency as to potential stumbling blocks that current PDs and chief/chairs of plastic surgery residency programs have faced during their initial training. This will help current trainees anticipate these stumbling blocks and place these in perspective based on the experience of senior plastic surgeons.
Surgical Management of Sirenomelia: A Case Study
Authors: Bhagat Neel D. , Patel Aadarsh , Gross Jeffrey N. , Borschel Gregory H. 
Published: September 2023

Background:
Sirenomelia is a rare congenital condition characterized by fusion of the lower limbs. Patients with sirenomelia generally do not survive long after birth because the condition is associated with multisystem organ dysfunction due to developmental anomalies. Considering the low incidence and few cases surviving the neonatal period, there is minimal understanding regarding the surgical management of sirenomelia. We present a unique case of an infant born with type 1 sirenomelia, absence of external genitalia, presence of a cloaca, absence of the bladder, and presence of an imperforate and vestigial anus, who not only survived the birth process, but, at the age of 11 months, was determined to be a candidate for surgical separation of the lower extremities.

Methods:
This case was approached much like a dorsal rectangular flap syndactyly release. Large Z-plasty flaps were designed and raised, and the soft tissue within the skin bridge was meticulously dissected to preserve anatomy and to provide adequate skin flaps without perineal skin grafting. A quadrangular flap was designed to reconstruct the perineum and produce a neo-vulva using de-epithelialization.

Results:
Successful lower extremity separation was achieved. There were no major postoperative complications. The patient progressed with lower extremity function, and eventually achieved independent ambulation.

Conclusions:
Management of sirenomelia is incredibly challenging, and data to guide surgical management are limited. This report details our approach to a successful lower extremity separation, repair, and neo-vulvar reconstruction in a case of type I sirenomelia.
Genotypes of Stim1 and the proximal region on chromosome 1 exert opposite effects on stroke susceptibility in stroke-prone spontaneously hypertensive rat
Authors: Ohara Hiroki , Takeuchi Fumihiko , Kato Norihiro , Nabika Toru 
Published: September 2023

Background:
The stroke-prone spontaneously hypertensive rat (SHRSP) is a genetic model for cerebral stroke. Although a recent study on a congenic SHRSP suggested that a nonsense mutation in stromal interaction molecule 1 (Stim1) encoding a major component of store-operated Ca2+ entry was a causal variant for stroke in SHRSP, this was not conclusive because the congenic region including Stim1 in that rat was too wide. On the other hand, we demonstrated that the Wistar–Kyoto (WKY)-derived congenic fragment adjacent to Stim1 exacerbated stroke susceptibility in a congenic SHRSP called SPwch1.71. In the present study, we directly examined the effects of the Stim1 genotype on stroke susceptibility using SHRSP in which wild-type Stim1 was knocked in (called Stim1-KI SHRSP). The combined effects of Stim1 and the congenic fragment of SPwch1.71 were also investigated.

Methods:
Stroke susceptibility was assessed by the stroke symptom-free and survival periods based on observations of behavioral symptoms and reductions in body weight.

Results:

Stim1-KI SHRSP was more resistant to, while SPwch1.71 was more susceptible to stroke than the original SHRSP. Introgression of the wild-type Stim1 of Stim1-KI SHRSP into SPwch1.71 by the generation of F1 rats ameliorated stroke susceptibility in SPwch1.71. Gene expression, whole-genome sequencing, and biochemical analyses identified Art2b, Folr1, and Pde2a as possible candidate genes accelerating stroke in SPwch1.71.

Conclusion:
The substitution of SHRSP-type Stim1 to wild-type Stim1 ameliorated stroke susceptibility in both SHRSP and SPwch1.71, indicating that the nonsense mutation in Stim1 is causally related to stroke susceptibility in SHRSP.
Research Letter: TBI Severity Moderates the Association Between Subjective and Objective Attention in Older Veterans
Authors: Rantins Peter , Ly Monica , Clark Alexandra L. , Weigand Alexandra J. , Alshaheri Durazo Alin , Merritt Victoria C. , Bangen Katherine J. , Thomas Kelsey R. 
Published: September 2023

Objective:
This study examined the moderating effect of traumatic brain injury (TBI) history on subjective and objective cognition across multiple cognitive domains.

Setting, Participants, and Design:
Participants included 242 Vietnam-era veterans with a history of no TBI (n = 86), mild TBI (n = 74), or moderate-to-severe TBI (n = 82) from the observational Department of Defense-Alzheimer's Disease Neuroimaging Initiative (DoD-ADNI) study.

Main Measures:
Objective cognition was the outcome and was measured using neuropsychological measures in the domains of memory, attention/executive functioning, and language. Subjective cognition was measured using the memory, divided attention, and language subscales from the Everyday Cognition (ECog) measure. TBI severity status was the moderating variable.

Results:
Veterans with a history of moderate-to-severe TBI had a stronger negative association between subjective and objective attention relative to participants without a TBI (P = .002). Although this association did not differ between mild TBI and no TBI history groups (P = .100), the association between subjective and objective attention for the mild TBI group was intermediate to the no TBI and moderate-to-severe TBI history groups. TBI status did not moderate associations between subjective and objective memory or language.

Conclusion:
Results highlight the importance of assessing subjective and objective cognition in older veterans and the relevance of attention in the context of TBI history. More work is needed to better understand the intersection of TBI and aging and how these factors may be used to guide individualized assessment and treatment approaches for older veterans.
Comparison Between Ocular Biometric Parameters and Intraocular Pressure With and Without Contact Lenses
Authors: Noya-Padin Veronica , Nores-Palmas Noelia , Giraldez Maria Jesus , Yebra-Pimentel Eva , Pena-Verdeal Hugo 
Published: September 2023

Objectives:
To compare the values of central corneal thickness, anterior chamber depth (ACD), lens thickness (LT), vitreous length (VL), axial length (AL), and corneal-compensated intraocular pressure performed with and without contact lenses (CL).

Methods:
Forty volunteer participants (16 men and 24 women, 24.2±2.9 years) were recruited. In a single visit, participants underwent autorefraction, keratometry, biometry, topography, pachymetry, and tonometry with the naked eye (without CL). Then, biometry, pachymetry, and tonometry were repeated twice wearing two CL (somofilcon A and nesofilcon A) fitted in a random order.

Results:
Many of the ocular biometric values were affected by the use of CL during measurements (paired t test; all P≤0.003), except for LT and VL (Wilcoxon test; both P≥0.272). Corneal-compensated intraocular pressure was also affected by contact lens wear during measurements, obtaining lower values when wearing them (Wilcoxon test; all P≤0.001).

Conclusions:
Central corneal thickness, ACD, AL, and corneal-compensated intraocular pressure measurements cannot be performed while wearing CL. However, LT and VL measurements were not affected by any contact lens use. In addition, it was observed that ACD results from both devices are not interchangeable either when measured with the naked eye or using any contact lens.