bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic spatiotemporal correlation coefficient based on adaptive weight
Authors: Mo Guoli , Tan Chunzhi , Zhang Weiguo , Yu Xuezeng 
Published: January 2023

AbstractRisk management is an important aspect of financial research because correlations among financial data are essential in evaluating portfolio risk. Among various correlations, spatiotemporal correlations involve economic entity attributes and are interrelated in space and time. Such correlations have therefore drawn increasing attention in financial risk management. However, classical correlation measurements are typically based on either time series correlations or spatial dependence; they cannot be directly applied to financial data with spatiotemporal correlations. The spatiotemporal correlation coefficient model with adaptive weight proposed in this paper can (1) address the absolute quantity, dynamic quantity, and dynamic development of financial data and (2) be used for risk grading, financial risk evaluation, and portfolio management. To verify the validity and superiority of this model, cluster analysis results and portfolio performance are compared with a classical model with time series correlation or spatial correlation, respectively. Empirical findings show that the proposed coefficient is highly effective and convenient compared to others. Overall, our method provides a highly efficient financial risk management method with valuable implications for investors and financial institutions.
Khangchiu: the youth dormitory of Liangmai Naga
Authors: Daimai Kailadbou 
Published: January 2023

AbstractThis paper is an attempt to highlight the significance of youth dormitory system of the Liangmai Naga of Manipur. This traditional institution played a vital role in imparting value education and maintaining the social fabric among the pre-literate Liangmai community. In the past, it serves as the cultural center, where young boys and girls are molded to become responsible adult members of the community. However, this highly developed institution of the Liangmai Naga has now disintegrated. Change in religious belief and the advent of modern education has been attributed for the decline of khangchiu. The paper reflexively analyzes the origin and decline of this traditional institution as well as the roles and functions it played in the traditional Liangmai society. The main objective of the paper is to document the systematic operation of the youth dormitory system so as to bring better understanding of this traditional institution to the younger generations.
Developmental assessment of infants with congenital heart disease: a cross-sectional study
Authors: Sheta Sahar , Amin Omnia R. , Elkateb Ahmed , El Toukhy Noha , Sayed Shaimaa 
Published: January 2023

Abstract
Background
Recently, marked improvement of medical and surgical care for infants with congenital heart disease led to a growing population with a high risk of developmental delay. We aimed to identify developmental delay in these infants and its risk factors. So, we performed a cross-sectional study on 100 infants with congenital heart disease to assess their development by using Vineland Adaptive Behaviour Scale. We searched for risk factors for developmental delay in these infants. Correlations were conducted between the degree of developmental delay and the potential risk factors. To our knowledge, this study has not been conducted in developing countries before.

Results
The median age of the study group is 12.5 months, but it is equivalent to 9.5 months by using Vineland Adaptive Behaviour Scale. There was a statistically significant developmental delay in infants who had risk factors such as prematurity, history of neonatal intensive care unit admission, anemia, stunted growth, underweight, central cyanosis, or abnormal electroencephalographic.

Conclusions
Developmental delay is a common complication in infants with congenital heart disease. It has many risk factors; some of them could be modifiable as anemia, stunted growth, and underweight. Thus, early screening for developmental delay and its risk factors is of a great value. This could help in applying preventive measures and early intervention programs. Vineland Adaptive Behaviour Scale is a reliable tool in determination of developmental delay in infants with congenital heart disease.
Imaging of tubercular mastitis presenting as recurrent breast nodules and abscesses: a rare case report
Authors: Singhal Annu , Kataria Bhavya , Sharma Swati 
Published: January 2023

Abstract
Background
Tubercular mastitis could be a rare diagnostic find clinically. It is largely seen in Asian, African and alternative non-developed countries and might occur with coincident primary tuberculosis of the respiratory tract or spine. Primary breast tuberculosis (TB) is even rarer and presents with non-specific clinical signs of continual breast masses, inflammation and sinus tracts. It can be similar to bacterial inflammation/abscess and malignant pathologies on imaging. The key to identification could be a holistic combination of imaging, clinical, biochemical and histopathological analysis.

Case presentation
We discuss a case of a 41-year-old lady who conferred at the start with tender breast nodules that progressed to continual, multiple abscesses and sinus tract formation. It had been an unusual and unanticipated presentation in breast followed by uncommon events throughout the course of the treatment forcing us to re-evaluate the primary diagnosis. A sequence of multiple diagnostic imaging and histopathological evaluations confirmed the identification of tubercular mastitis. Following prolonged treatment, there was vital reduction within the range and size of nodules and abscesses.

Conclusions
Such cases imitate bacterial abscess and cancer in their clinical presentation and imaging findings and are imperative to be diagnosed via a myriad of diagnostic tests with histopathology. Such a clinical presentation should warrant a differential of granulomatous inflammation of the breast in cases of non-responders to incision and drainage, prolonged antibiotic medical therapy and prolonged anti-tubercular treatment up to twenty four months after assessment of the individual response.
Prevalence of coronary artery fistula in adults performing coronary CT angiography among Egyptian population: a single center study
Authors: Mubarak Amr Ahmed 
Published: January 2023

Abstract
Background
The prevalence of coronary artery fistula (CAF) among Egyptian population is increasing due to widespread availability of coronary CT angiography using high-end CT scanners. The purpose of this observational study was to determine the incidence and types of CAF detected among Egyptian population during routinely performed coronary CT angiography.

Results
Among the 2263 retrospectively evaluated CT coronary angiography studies, CAF was detected only in 17 (0.75%) patients with proximal LAD being the commonest vessel of origin; in 5 cases (29.4%) and main pulmonary artery (MPA) the commonest site of fistula termination; in 3 cases (17.6%). Indeterminate site of fistula termination was present in two cases (11.7%) due to limited scan coverage.

Conclusions
Multislice coronary CT angiography is a useful non-invasive imaging modality for diagnosis of CAF by demonstrating vessel of origin, course and site of termination, with CAF prevalence and types among Egyptian population being reported in this study based on routinely performed coronary CT angiography.
Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats
Authors: Pingili Ravindra Babu , Vemulapalli Sridhar , Mullapudi Surya Sandeep , Dirisala Vijaya R. , Chanumolu Harsha Sai , Kilaru Naveen Babu 
Published: January 2023

Abstract
Background
Metoprolol is a substrate of CYP3A4, 2B6, CYP2D6, CYP2C9, and p-glycoprotein (p-gp). Hesperetin was reported as an inhibitor of cytochrome P-450 (CYP) enzymes and p-gp. The objective of this study was to investigate the effect of hesperetin on the pharmacokinetics of metoprolol in rats and in vitro models. In in vivo studies, male Wistar rats were treated with metoprolol (30 mg/kg) once a day for 15 consecutive days alone and in combination with hesperetin (25, 50, and 100 mg/kg). Blood samples were withdrawn from the tail vein on the 1st day in the single-dose pharmacokinetic study and on the 15th day in the repeated-dose pharmacokinetic study. In in vitro studies, metoprolol was incubated in the presence or absence of hesperetin and traditional p-gp inhibitors using rat-everted gut sacs. Reverse phase-high-performance liquid chromatography (RP-HPLC) was used to determine the amounts of metoprolol in the plasma and incubated samples (RP-HPLC).

Results
The Cmax, AUC, and half-life (t1/2) of metoprolol significantly increased by twofold compared to the metoprolol group in rats pre-treated with hesperetin. The clearance and volume of distribution both decreased significantly. Metoprolol transport was dramatically increased in the presence of hesperetin and quinidine (standard p-gp inhibitor) in in vitro study.

Conclusion
The present study results revealed that hesperetin significantly increased the absorption of metoprolol in rats and everted gut sacs in vitro might be due to the inhibition of CYP and p-gp.
Varied presentations of complicated rhinosinusitis in COVID era: a rational approach to management
Authors: Thakur Shivali , Patnaik Uma , Saxena Pavitra , Tevatia Manvir Singh , Dwivedi Gunjan , Kumari Abha , Rao Nusumu Purnachandra , Sood Amit 
Published: January 2023

Abstract
Aim
To study the various presentations and manifestations of complicated rhinosinusitis in COVID era- ranging from bacterial rhino sinusitis to invasive fungal rhino sinusitis.

Methods
Design-A retrospective observational study was carried out from March 2020 to May 2021. Setting-Tertiary care hospital subjects—all COVID-positive patients who had paranasal sinus involvement. Methods-Patients were evaluated based on their symptomatology profile. Fungal stains and culture were carried out for all. They underwent Magnetic resonance Imaging and Computed Tomography scan on case-to-case basis, apart from routine nasal endoscopy. All were managed both medically and surgically depending upon their diagnosis. The natural course including outcomes, was studied, documented and analyzed.

Results
Out of 496 patients presenting with sinonasal disease, 126 were COVID-positive, 16 patients had complicated rhino sinusitis, of which 4 patients had complicated rhinosinusitis with intraorbital, intracranial or combined complications. All patients were managed successfully with combined medical and surgical approach. Twelve patients had invasive mucormycosis with overall mortality rate of 37%.

Conclusion
Complicated sinusitis was encountered in COVID-positive patients either when they were being actively treated for COVID-19 or as part of post-COVID sequalae. Though rhino-orbito-cerebral mucormycosis constituted the major disease burden in such patients but the possibility of bacterial rhino sinusitis with or without complications must also be kept in mind while evaluating such patients. We must remember every complicated rhinosinusitis in COVID-positive patient may not be mucor and manage appropriately.
The devil is in the detail: a critique of nine editorials published by the International Task Force on Benzodiazepines
Authors: Brandt Jaden 
Published: January 2023

SUMMARYSince 2018, the International Task Force on Benzodiazepines (ITFB), a group of academic psychiatrists and academic psychologists, has advocated that clinical guidelines should change to promote benzodiazepines from second- to first-line treatment for anxiety disorders, accept their use as maintenance treatment for anxiety conditions (in particular, panic disorder) and increase their use in gastrointestinal disorders. There is merit in much of what the ITFB argues, but in this article I analyse four major claims it has made in opinion editorials that I believe are not fully supported by the available evidence.
The first appearance of EEG evidence in a UK court of law: a cautionary tale
Authors: Barrett Ken 
Published: January 2023

SummaryElectroencephalogram-based evidence was accepted in a UK law court for the first time in 1939. This paper gives an account of that case, not previously clinically reported, and the individuals involved. Why it was not published in the literature at the time is explored and parallels with more recent technologies are highlighted.
Supporting return to work after psychiatric hospitalization—A cluster randomized study (RETURN-study)
Authors: Hamann Johannes , Lang Anne , Riedl Lina , Blank Daniela , Kohl Monika , Brucks Adele , Goretzko David , Bühner Markus , Waldmann Tamara , Kilian Reinhold , Falkai Peter , Hasan Alkomiet , Keck Martin E. , Landgrebe Michael , Heres Stephan , Brieger Peter 
Published: January 2023

Abstract

Background
If people with episodic mental-health conditions lose their job due to an episode of their mental illness, they often experience personal negative consequences. Therefore, reintegration after sick leave is critical to avoid unfavorable courses of disease, longer inability to work, long payment of sickness benefits, and unemployment. Existing return-to-work (RTW) programs have mainly focused on “common mental disorders” and often used very elaborate and costly interventions without yielding convincing effects. It was the aim of the RETURN study to evaluate an easy-to-implement RTW intervention specifically addressing persons with mental illnesses being so severe that they require inpatient treatment.

Methods
The RETURN study was a multi-center, cluster-randomized controlled trial in acute psychiatric wards addressing inpatients suffering from a psychiatric disorder. In intervention wards, case managers (RTW experts) were introduced who supported patients in their RTW process, while in control wards treatment, as usual, was continued.

Results
A total of 268 patients were recruited for the trial. Patients in the intervention group had more often returned to their workplace at 6 and 12 months, which was also mirrored in more days at work. These group differences were statistically significant at 6 months. However, for the main outcome (days at work at 12 months), differences were no longer statistically significant (p = 0.14). Intervention patients returned to their workplace earlier than patients in the control group (p = 0.040).

Conclusions
The RETURN intervention has shown the potential of case-management interventions when addressing RTW. Further analyses, especially the qualitative ones, may help to better understand limitations and potential areas for improvement.
Evolutionary dynamics in networked trust games with diverse investment patterns
Authors: Shang Lihui , Zhang Tiantian , Chang Min 
Published: January 2023

Abstract
Most previous works study the evolution of trust by commonly assuming that investors adopt a deterministic investment strategy. In this work, we propose a mechanism of diverse investment in the trust game model on social networks, where each investor adopts a probabilistic strategy by considering the trustworthiness level in the local group to decide whether to invest or not. Extensive simulation results suggest that the proposed mechanism inhibits the untrustworthy behavior and limits its spread, thus stabilizing the cooperative cluster of investors and trustworthy trustees. Therefore, the trust level and global wealth are greatly enhanced comparing to the traditional setup with homogeneous investment pattern. The strong investment diversity can even eliminate untrustworthiness completely despite the fact that the severe temptation condition is disadvantageous to the evolution of trust. We also investigate the impact of investment diversity on trust game model embedding in different network structures with different initial conditions, where we observe similarly positive evolutionary outcomes. We hope these observations can provide valuable insights into further exploring the improvement of trust in real life.
Preconception Thyrotropin Levels and Thyroid Function at Early Gestation in Women With Hashimoto Thyroiditis
Authors: Moleti Mariacarla , Alibrandi Angela , Di Mauro Maria , Paola Giuseppe , Perdichizzi Laura Giovanna , Granese Roberta , Giacobbe Annamaria , Scilipoti Angela , Ragonese Marta , Ercoli Alfredo , Benvenga Salvatore , Vermiglio Francesco 
Published: January 2023

Abstract

Context
Preconception optimization of thyroid function in women with Hashimoto thyroiditis (HT) is highly recommended to prevent/reduce the risk of thyroid insufficiency at early gestation.

Objective
This work aimed to evaluate the prevalence of first-trimester thyroid insufficiency in HT women with preconception thyrotropin (T0-TSH) values consistently less than or equal to 2.5 mIU/L with or without levothyroxine (LT4) treatment, and to calculate T0-TSH cutoffs that best preconceptionally identified HT women requiring first-trimester LT4 adjustment/prescription.

Methods
Serum TSH was obtained at 4- to 6-week intervals from 260 HT pregnant women (122 on LT4 [Hypo-HT]; 138 euthyroid without LT4 [Eu-HT]), prospectively followed from preconception up to pregnancy term. Receiver operating characteristic (ROC) curves were plotted to identify T0-TSH cutoffs best predicting first-trimester TSH levels greater than 2.5 mIU/L (diagnostic criterion [DC] 1) and greater than 4.0 mIU/L (DC 2).

Results
At first trimester, TSH was greater than 2.5 mIU/L in approximately 30% of both Hypo-HT and Eu-HT women, and greater than 4.0 mIU/L in 19.7% Hypo-HT and 10.1% Eu-HT women (P = .038). The optimal ROC-based T0-TSH cutoffs found were 1.24 mIU/L/1.74 mIU/L in Hypo-HT, and 1.73 mIU/L/2.07 mIU/L in Eu-HT women, for DC 1 and DC 2, respectively. T0-TSH values exceeding these cutoffs resulted in a statistically significantly increased risk of first-trimester thyroid insufficiency (odds ratio [OR] [95% CI)] 15.92 [5.06-50.15] and 16.68 [5.13-54.24] in Hypo-HT; 16.14 [6.47-40.30] and 17.36 [4.30-70.08] in Eu-HT women, for DC 1 and DC 2, respectively).

Conclusion
The preconception TSH cutoffs that guaranteed a first-trimester TSH less than 2.5 mU/L in hypothyroid- and euthyroid-HT women were, respectively, almost 50% (1.24 mU/L) and 30% (1.73 mU/L) lower than this gestational target, and 1.74 mU/L and 2.07 mU/L in hypothyroid- and euthyroid-HT women, respectively, for a gestational target of 4.0 mU/L.
Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through α5 integrin signaling
Authors: Li Xiaofei , McLain Callie , Samuel Michael S. , Olson Michael F. , Radice Glenn L. 
Published: January 2023

ABSTRACTThe cardiomyocyte phenotypic switch from a proliferative to terminally differentiated state results in the loss of regenerative potential of the mammalian heart shortly after birth. Nonmuscle myosin IIB (NM IIB)-mediated actomyosin contractility regulates cardiomyocyte cytokinesis in the embryonic heart, and NM IIB levels decline after birth, suggesting a role for cellular tension in the regulation of cardiomyocyte cell cycle activity in the postnatal heart. To investigate the role of actomyosin contractility in cardiomyocyte cell cycle arrest, we conditionally activated ROCK2 kinase domain (ROCK2:ER) in the murine postnatal heart. Here, we show that α5/β1 integrin and fibronectin matrix increase in response to actomyosin-mediated tension. Moreover, activation of ROCK2:ER promotes nuclear translocation of Yap, a mechanosensitive transcriptional co-activator, and enhances cardiomyocyte proliferation. Finally, we show that reduction of myocardial α5 integrin rescues the myocardial proliferation phenotype in ROCK2:ER hearts. These data demonstrate that cardiomyocytes respond to increased intracellular tension by altering their intercellular contacts in favor of cell–matrix interactions, leading to Yap nuclear translocation, thus uncovering a function for nonmuscle myosin contractility in promoting cardiomyocyte proliferation in the postnatal heart.
NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naïve pluripotent stem cells
Authors: Maskalenka Katsiaryna , Alagöz Gökberk , Krueger Felix , Wright Joshua , Rostovskaya Maria , Nakhuda Asif , Bendall Adam , Krueger Christel , Walker Simon , Scally Aylwyn , Rugg-Gunn Peter J. 
Published: January 2023

ABSTRACT
Gene duplication events can drive evolution by providing genetic material for new gene functions, and they create opportunities for diverse developmental strategies to emerge between species. To study the contribution of duplicated genes to human early development, we examined the evolution and function of NANOGP1, a tandem duplicate of the transcription factor NANOG. We found that NANOGP1 and NANOG have overlapping but distinct expression profiles, with high NANOGP1 expression restricted to early epiblast cells and naïve-state pluripotent stem cells. Sequence analysis and epitope-tagging revealed that NANOGP1 is protein coding with an intact homeobox domain. The duplication that created NANOGP1 occurred earlier in primate evolution than previously thought and has been retained only in great apes, whereas Old World monkeys have disabled the gene in different ways, including homeodomain point mutations. NANOGP1 is a strong inducer of naïve pluripotency; however, unlike NANOG, it is not required to maintain the undifferentiated status of human naïve pluripotent cells. By retaining expression, sequence and partial functional conservation with its ancestral copy, NANOGP1 exemplifies how gene duplication and subfunctionalisation can contribute to transcription factor activity in human pluripotency and development.
Intravital imaging of Wnt/β-catenin and ATF2-dependent signalling pathways during tumour cell invasion and metastasis
Authors: Stoletov Konstantin , Sanchez Saray , Gorroño Irantzu , Rabano Miriam , Vivanco Maria d. M. , Kypta Robert , Lewis John D. 
Published: January 2023

ABSTRACT
Wnt signalling has been implicated as a driver of tumour cell metastasis, but less is known about which branches of Wnt signalling are involved and when they act in the metastatic cascade. Here, using a unique intravital imaging platform and fluorescent reporters, we visualised β-catenin/TCF-dependent and ATF2-dependent signalling activities during human cancer cell invasion, intravasation and metastatic lesion formation in the chick embryo host. We found that cancer cells readily shifted between states of low and high canonical Wnt activity. Cancer cells that displayed low Wnt canonical activity showed higher invasion and intravasation potential in primary tumours and in metastatic lesions. In contrast, cancer cells showing low ATF2-dependent activity were significantly less invasive both at the front of primary tumours and in metastatic lesions. Simultaneous visualisation of both these reporters using a double-reporter cell line confirmed their complementary activities in primary tumours and metastatic lesions. These findings might inform the development of therapies that target different branches of Wnt signalling at specific stages of metastasis.