bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide association and epistasis studies reveal the genetic basis of saline-alkali tolerance at the germination stage in rice
Authors: Zhang Guogen , Bi Zhiyuan , Jiang Jing , Lu Jingbing , Li Keyang , Bai Di , Wang Xinchen , Zhao Xueyu , Li Min , Zhao Xiuqin , Wang Wensheng , Xu Jianlong , Li Zhikang , Zhang Fan , Shi Yingyao 
Published: May 2023

IntroductionSaline-alkali stress is one of the main abiotic factors limiting rice production worldwide. With the widespread use of rice direct seeding technology, it has become increasingly important to improve rice saline-alkali tolerance at the germination stage. MethodsTo understand the genetic basis of saline-alkali tolerance and facilitate breeding efforts for developing saline-alkali tolerant rice varieties, the genetic basis of rice saline-alkali tolerance was dissected by phenotyping seven germination-related traits of 736 diverse rice accessions under the saline-alkali stress and control conditions using genome-wide association and epistasis analysis (GWAES).ResultsTotally, 165 main-effect quantitative trait nucleotides (QTNs) and 124 additional epistatic QTNs were identified as significantly associated with saline-alkali tolerance, which explained a significant portion of the total phenotypic variation of the saline-alkali tolerance traits in the 736 rice accessions. Most of these QTNs were located in genomic regions either harboring saline-alkali tolerance QTNs or known genes for saline-alkali tolerance reported previously. Epistasis as an important genetic basis of rice saline-alkali tolerance was validated by genomic best linear unbiased prediction in which inclusion of both main-effect and epistatic QTNs showed a consistently better prediction accuracy than either main-effect or epistatic QTNs alone. Candidate genes for two pairs of important epistatic QTNs were suggested based on combined evidence from the high-resolution mapping plus their reported molecular functions. The first pair included a glycosyltransferase gene LOC_Os02g51900 (UGT85E1) and an E3 ligase gene LOC_Os04g01490 (OsSIRP4), while the second pair comprised an ethylene-responsive transcriptional factor, AP59 (LOC_Os02g43790), and a Bcl-2-associated athanogene gene, OsBAG1 (LOC_Os09g35630) for salt tolerance. Detailed haplotype analyses at both gene promoter and CDS regions of these candidate genes for important QTNs identified favorable haplotype combinations with large effects on saline-alkali tolerance, which can be used to improve rice saline-alkali tolerance by selective introgression. DiscussionOur findings provided saline-alkali tolerant germplasm resources and valuable genetic information to be used in future functional genomic and breeding efforts of rice saline-alkali tolerance at the germination stage.
Are two naïve and distributed heads better than one? Factors influencing the performance of teams in a challenging real-time task
Authors: Blanchard Matthew D. , Kleitman Sabina , Aidman Eugene 
Published: May 2023

IntroductionCollective decisions in dynamic tasks can be influenced by multiple factors, including the operational conditions, quality and quantity of communication, and individual differences. These factors may influence whether two heads perform better than one. This study examined the “two heads are better than one” effect (2HBT1) in distributed two-person driver-navigator teams with asymmetrical roles performing a challenging simulated driving task. We also examined the influence of communication quality and quantity on team performance under different operational conditions. In addition to traditional measures of communication volume (duration and speaking turns), patterns of communication quality (optimality of timing and accuracy of instructions) were captured.MethodsParticipants completed a simulated driving task under two operational conditions (normal and fog) either as individual drivers (N = 134; 87 females, mean age = 19.80, SD = 3.35) or two-person teams (driver and navigator; N = 80; 109 females, mean age = 19.70, SD = 4.69). The normal condition was characterized by high visibility for both driver and navigator. The fog condition was characterized by reduced visibility for the driver but not for the navigator. Participants were also measured on a range of cognitive and personality constructs.ResultsTeams had fewer collisions than individuals during normal conditions but not during fog conditions when teams had an informational advantage over individuals. Furthermore, teams drove slower than individuals during fog conditions but not during normal conditions. Communication that was poorly timed and/or inaccurate was a positive predictor of accuracy (i.e., collisions) during the normal condition and communication that was well timed and accurate was a negative predictor of speed during the fog condition. Our novel measure of communication quality (i.e., content of communication) was a stronger predictor of accuracy, but volume of communication was a stronger predictor of time (i.e., speed).DiscussionResults indicate when team performance thrives and succumbs compared with individual performance and informs theory about the 2HBT1 effect and team communication.
Individual perspectives and mental maps of working conditions and intention to stay of physicians in academic medicine
Authors: Hasebrook Joachim , Hecke Juliane , Volkert Thomas , Singer Maren , Hinkelmann Juergen , Michalak Leonie , Hahnenkamp Klaus 
Published: May 2023

IntroductionJob satisfaction has a strong impact on the intention to stay which is an important aspect to counter skills shortage in academic medicine. The purpose of the three studies reported here is to find out what specific factors are relevant for the intention to stay and turnover intention of physicians in academic medicine –and what measures might have a positive impact on employee retention.MethodsIn an interview study combining qualitative and quantitative methods, we investigated how the individual mental representation of working conditions influences job satisfaction and its impact on the intention to stay. In total, 178 physicians from German university hospitals, residents, and physicians, in 15 departments of anesthesiology were interviewed and surveyed. In a first study, chief physicians participated in interviews about job satisfaction in academic hospitals. Answers were segmented into statements, ordered by topics, and rated according to their valence. In a second study, assistant physicians during and after their training period talked about strengths, weaknesses, and potential improvements of working conditions. Answers were segmented, ordered, rated, and used to develop a “satisfaction scale.” In a third study, physicians participated in a computer-led repertory grid procedure composing ‘mental maps’ of job satisfaction factors, filled in the job satisfaction scale and rated if they would recommend work and training in their clinic as well as their intention to stay.ResultsComparing the interview results with recommendation rates and intention to stay show that high workload and poor career perspectives are linked to a negative attitude. A positive attitude towards work environment and high intention to stay is based on sufficient personnel and technical capacities, reliable duty scheduling and fair salaries. The third study using repertory grids showed that the perception of current teamwork and future developments concerning work environment were the main aspects to improve job satisfaction and the intention to stay.DiscussionThe results of the interview studies were used to develop an array of adaptive improvement measure. The results support prior findings that job dissatisfaction is mostly based on generally known “hygiene factors” and whereas job satisfaction is due to individual aspects.
The prevalence of post-traumatic stress disorder in college students by continents and national income during the COVID-19 pandemic: a meta-analysis
Authors: Hu Biao , Yang Xiling , Tuo Xiaoqian 
Published: May 2023

IntroductionThe present study aimed to provide a more accurate representation of post-traumatic stress disorder (PTSD) in college students during COVID-19 by performing meta-analyses by continents, national income, and study majors, and comparing the results with estimated pooled prevalence.MethodsBased on the guideline of PRISMA, literature was searched in PubMed, Web of Science, and Embase. The prevalence of PTSD was estimated through a random model based on the different continents and levels of national income, as well as study majors, and compared with the pooled prevalence of PTSD among college students.ResultsTotally 381 articles were retrieved from electronic databases and 38 articles were included in the present meta-analysis. The results showed that the pooled prevalence of college students’ PTSD was 25% (95% CI: 21–28%). Prevalence estimates of PTSD among college students were statistically significant (p &lt; 0.00001) when stratified with geographical regions, income levels, and study majors. In comparison with the pooled prevalence of PTSD (25%), subgroups of Africa and Europe, lower-middle-income countries, and medical college students possessed higher prevalence estimates.DiscussionThe findings of the study showed that the prevalence of PTSD in college students worldwide during COVID-19 was relatively high and varied in different continents and countries with different income levels. Therefore, healthcare providers should pay attention to the psychologically healthy condition of college students during COVID-19.
It turned into something else: patients’ long-term experiences of transitions to or from telepsychotherapy during the COVID-19 pandemic
Authors: von Below Camilla , Bergsten Jenny , Midbris Therése , Philips Björn , Werbart Andrzej 
Published: May 2023

IntroductionThe shift from in-person therapy to telepsychotherapy during the COVID-19 pandemic was unprepared for, sudden, and inevitable. This study explored patients’ long-term experiences of transitions to telepsychotherapy and back to the office.MethodsData were collected approximately two years after the declaration of COVID-19 as a pandemic. Eleven patients were interviewed (nine women and two men, aged 28 to 56, six in psychodynamic psychotherapy, five in CBT). Treatments switched between in-person and video/telephone sessions. Interview transcripts were analyzed applying the qualitative methodology of inductive thematic analysis.Results(1) The patients experienced the process in telepsychotherapy as impeded. Interventions were difficult to understand and lost impact. Routines surrounding the therapy sessions were lost. Conversations were less serious and lost direction. (2) Understanding was made more difficult when the nuances of non-verbal communication were lost. (3) The emotional relationship was altered. Remote therapy was perceived as something different from regular therapy, and once back in the therapy room, the patients felt that therapy started anew. The emotional presence was experienced as weakened, but some of the patients found expressing their feelings easier in the absence of bodily co-presence. According to the patients, in-person presence contributed to their security and trust, whereas they felt that the therapists were different when working remotely, behaving in a more easygoing and familiar way, as well as more solution-focused, supportive and unprofessional, less understanding and less therapeutic. Despite this, (4) telepsychotherapy also gave the patients an opportunity to take therapy with them into their everyday lives.DiscussionThe results suggest that in the long run, remote psychotherapy was seen as a good enough alternative when needed. The present study indicates that format alternations have an impact on which interventions can be implemented, which can have important implications for psychotherapy training and supervision in an era when telepsychotherapy is becoming increasingly common.
Modeling the effect of loving pedagogy dispositions and teacher self-efficacy on teacher burnout
Authors: Chen Shuya 
Published: May 2023

IntroductionForeign language teaching is a demanding and challenging profession, and teacher burnout is a common issue in this field. There is a growing research interest in exploring the factors that can protect teachers from burnout and promote their well-being, as well as their effectiveness in the classroom. One such factor might be loving pedagogy, which refers to a teacher’s positive and compassionate attitudes and behaviors toward their students. This study aimed to examine the association between Dispositions toward Loving Pedagogy (DTLP), teacher self-efficacy, and teacher burnout among a sample of Chinese English as a foreign language (EFL) teachers.MethodsThe participants included 428 English teachers from various parts of China. Data on the three constructs were gathered using an electronic survey which comprised three valid questionnaires for these variables. Structural equation modeling (SEM) was used to test the hypothesized relations among the latent constructs.ResultsThe results indicated that loving pedagogy dispositions negatively affected teacher burnout and that teacher self-efficacy mediated the effect of loving pedagogy on burnout. More precisely, higher levels of loving pedagogy were associated with greater levels of teacher self-efficacy, which is in turn negatively affected teacher burnout.DiscussionThese outcomes shed more light on the importance of loving pedagogy dispositions for teachers’ mental health and well-being. The findings have implications for theory and practice, as they suggest that fostering loving pedagogy dispositions among teachers can help prevent burnout and promote their well-being. Teacher training programs could integrate this construct into their curricula to support teachers in developing these attitudes and behaviors. Additionally, future research could explore ways to enhance loving pedagogy and self-efficacy among teachers and assess their impact on teacher well-being and effectiveness.
Prevalence of depression and its association with quality of life among guardians of hospitalized psychiatric patients during the COVID-19 pandemic: a network perspective
Authors: Zhao Yan-Jie , Zhang Ling , Feng Yuan , Sha Sha , Lam Mei Ieng , Wang Yue-Ying , Li Jia-Xin , Su Zhaohui , Cheung Teris , Ungvari Gabor S. , Jackson Todd , An Feng-Rong , Xiang Yu-Tao 
Published: May 2023

BackgroundThe COVID-19 pandemic has greatly affected treatment-seeking behaviors of psychiatric patients and their guardians. Barriers to access of mental health services may contribute to adverse mental health consequences, not only for psychiatric patients, but also for their guardians. This study explored the prevalence of depression and its association with quality of life among guardians of hospitalized psychiatric patients during the COVID-19 pandemic.MethodsThis multi-center, cross-sectional study was conducted in China. Symptoms of depression and anxiety, fatigue level and quality of life (QOL) of guardians were measured with validated Chinese versions of the Patient Health Questionnaire – 9 (PHQ-9), Generalized Anxiety Disorder Scale – 7 (GAD-7), fatigue numeric rating scale (FNRS), and the first two items of the World Health Organization Quality of Life Questionnaire - brief version (WHOQOL-BREF), respectively. Independent correlates of depression were evaluated using multiple logistic regression analysis. Analysis of covariance (ANCOVA) was used to compare global QOL of depressed versus non-depressed guardians. The network structure of depressive symptoms among guardians was constructed using an extended Bayesian Information Criterion (EBIC) model.ResultsThe prevalence of depression among guardians of hospitalized psychiatric patients was 32.4% (95% CI: 29.7–35.2%). GAD-7 total scores (OR = 1.9, 95% CI: 1.8–2.1) and fatigue (OR = 1.2, 95% CI: 1.1–1.4) were positively correlated with depression among guardians. After controlling for significant correlates of depression, depressed guardians had lower QOL than non-depressed peers did [F(1, 1,101) = 29.24, p &lt; 0.001]. “Loss of energy” (item 4 of the PHQ-9), “concentration difficulties” (item 7 of the PHQ-9) and “sad mood” (item 2 of the PHQ-9) were the most central symptoms in the network model of depression for guardians.ConclusionAbout one third of guardians of hospitalized psychiatric patients reported depression during the COVID-19 pandemic. Poorer QOL was related to having depression in this sample. In light of their emergence as key central symptoms, “loss of energy,” “concentration problems,” and “sad mood” are potentially useful targets for mental health services designed to support caregivers of psychiatric patients.
Trends and burden in mental disorder death in China from 2009 to 2019: a nationwide longitudinal study
Authors: Wu Jiawen , Wang Yuzhu , Wang Lu , Wu Hengjing , Li Jue , Zhang Lijuan 
Published: May 2023

ObjectivesWe aimed to elucidate trends in the crude mortality rate (CMR), age-standardized mortality rate (ASMR), and burden of mental disorders (MD) in China.MethodsA longitudinal observational study was performed using the data of MD deaths in the National Disease Surveillance System (DSPs) during 2009–2019. The mortality rates were normalized using the Segis global population. Trends in the mortality of MDs stratified by age, gender, region, and residency, respectively. The burden of MD was evaluated using age-standardized person years of life loss per 100,000 people (SPYLLs) and average years of life lost (AYLL).ResultA total of 18,178 MD deaths occurred during 2009–2019, accounting for 0.13% of total deaths, and 68.3% of MD deaths occurred in rural areas. The CMR of MD in China was 0.75/100,00 persons (ASMR: 0.62/100,000 persons). The ASMR of all MDs decreased mainly due to the decrease in ASMR in rural residents. Schizophrenia and alcohol use disorder (AUD) were the leading causes of death in MD patients. The ASMR of schizophrenia and AUD was higher in rural residents than in urban residents. The ASMR of MD was highest in the 40–64 age group. As the leading causes of MD burden, the SPYLL and AYLL of schizophrenia were 7.76 person-years and 22.30 years, respectively.ConclusionAlthough the ASMR of all MDs decreased during 2009–2019, schizophrenia and AUD were still the most important causes of death for MDs. Targeted efforts focusing on men, rural residents, and the 40–64 years old population should be strengthened to decrease MD-related premature deaths.
The immaturity of patient engagement in value-based healthcare—A systematic review
Authors: van der Voorden Michael , Sipma Wim S. , de Jong Margriet F. C. , Franx Arie , Ahaus Kees C. T. B. 
Published: May 2023

IntroductionIn recent years, Value-Based Healthcare (VBHC) has been gaining traction, particularly in hospitals. A core VBHC element is patient value, i.e., what matters most to the patient and at what cost can this be delivered. This interpretation of value implies patient engagement in patient–doctor communication. Although patient engagement in direct care in the VBHC setting is well described, patient engagement at the organizational level of improving care has hardly been studied. This systematic review maps current knowledge regarding the intensity and impact of patient engagement in VBHC initiatives. We focus on the organizational level of a continuous patient engagement model.MethodsWe performed a systematic review following PRISMA guidelines using five electronic databases. The search strategy yielded 1,546 records, of which 21 studies were eligible for inclusion. Search terms were VBHC and patient engagement, or similar keywords, and we included only empirical studies in hospitals or transmural settings at the organizational level.ResultsWe found that consultation, using either questionnaires or interviews by researchers, is the most common method to involve patients in VBHC. Higher levels of patient engagement, such as advisory roles, co-design, or collaborative teams are rare. We found no examples of the highest level of patient engagement such as patients co-leading care improvement committees.ConclusionThis study included 21 articles, the majority of which were observational, resulting in a limited quality of evidence. Our review shows that patient engagement at the organizational level in VBHC initiatives still relies on low engagement tools such as questionnaires and interviews. Higher-level engagement tools such as advisory roles and collaborative teams are rarely used. Higher-level engagement offers opportunities to improve healthcare and care pathways through co-design with the people being served. We urge VBHC initiatives to embrace all levels of patient engagement to ensure that patient values find their way to the heart of these initiatives.
System Integrated Digital Empowering and teleRehabilitation to promote patient Activation and well-Being in chronic disabilities: A usability and acceptability study
Authors: Rossetto Federica , Borgnis Francesca , Isernia Sara , Foglia Emanuela , Garagiola Elisabetta , Realdon Olivia , Baglio Francesca 
Published: May 2023

IntroductionTelerehabilitation systems represent a promising way for the management of chronic disability, delivering technology-enabled rehabilitation outside the hospital setting. However, usability and acceptability assessment with users represents a critical starting point when using digital healthcare solutions. This study aims at evaluating the user experience with a Telerehabilitation system (SIDERA∧B) from the end-user side.MethodsSIDERA∧B consists of an asynchronous delivery of rehabilitation activities through multimedia digital contents and tele-monitoring of vital parameters with technological devices for individualized, home-based management of chronic conditions. Usability (with the System Usability Scale, SUS) and acceptability (using the Technology Acceptance Model, TAM - and The Service User Technology Acceptance Questionnaire, SUTAQ) data were analyzed from the dataset of the SIDERA∧B project (N = 112 patients with Chronic Heart Failure, Parkinson's Disease and Chronic Obstructive Pulmonary Disease). The possible influence of five external factors (i.e., technological expertise, education, sex, age, and level of disability) on TAM domains was tested using Spearman's Correlation analysis.ResultsResults showed a satisfactory level of technological usability (SUS Median = 77.5) and good scores in usability and learnability SUS subdomains (mean scores &gt; 2.5). Regarding technological acceptability, participants showed high scores (Median &gt; 4) in “Behavioral Intention”, “Perceived Usefulness”, and “Perceived Ease of Use” TAM domains. Finally, results from the SUTAQ scale highlighted that the SIDERA∧B system obtained optimal scores in all domains, especially in “Increased accessibility,” “Care personnel concerns,” and “Satisfaction.” Age (rho = −0.291, p = 0.002) and disability level (WHODAS Total score: rho = −0.218, p = 0.021) were the two external factors inversely associated with the Perceived Ease of Use.DiscussionThe age of digital transformation requires everyone to understand, accept and master the changes affecting modern-day healthcare. The usability and acceptability of the SIDERA∧B system were high across all end-users, despite the medium-low level of the technological expertise of the sample. These findings support the efficiency and the suitability of these digital solutions in the modern digital age transition of rehabilitation from inside to outside the clinic.