bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early sensory gain control is dominated by obligatory and global feature-based attention in top-down shifts of combined spatial and feature-based attention
Authors: Gundlach Christopher , Wehle Sebastian , Müller Matthias M 
Published: August 2023

AbstractWhat are the dynamics of global feature-based and spatial attention, when deployed together? In an attentional shifting experiment, flanked by three control experiments, we investigated neural temporal dynamics of combined attentional shifts. For this purpose, orange- and blue-frequency-tagged spatially overlapping Random Dot Kinematograms were presented in the left and right visual hemifield to elicit continuous steady-state-visual-evoked-potentials. After being initially engaged in a fixation cross task, participants were at some point in time cued to shift attention to one of the Random Dot Kinematograms, to detect and respond to brief coherent motion events, while ignoring all such events in other Random Dot Kinematograms. The analysis of steady-state visual-evoked potentials allowed us to map time courses and dynamics of early sensory-gain modulations by attention. This revealed a time-invariant amplification of the to-be attended color both at the attended and the unattended side, followed by suppression for the to-be-ignored color at attended and unattended sides. Across all experiments, global and obligatory feature-based selection dominated early sensory gain modulations, whereas spatial attention played a minor modulatory role. However, analyses of behavior and neural markers such as alpha-band activity and event-related potentials to target- and distractor-event processing, revealed clear modulations by spatial attention.
Exploring exposure to multiple psychosocial work factors: prospective associations with depression and sickness absence
Authors: Lunen Jonas Christian , Rugulies Reiner , Sørensen Jeppe K , Andersen Lars L , Clausen Thomas 
Published: August 2023

Abstract

Background
Most studies on the psychosocial working environment have focused on evaluating the isolated effect of individual psychosocial work factors or looked at effects through a lens of theories such as job strain or effort–reward imbalance. However, to fathom the intricate nature of workers’ experience of occupational strain, there is a need to investigate the combined and cumulative effects of multiple exposures to psychosocial work factors on workers’ health.

Methods
In this prospective cohort study, we created an additive index (range 0–4) on number of baseline exposures to quantitative demands, emotional demands, role conflicts, and workplace bullying. Via logistic regression and Cox regression, we estimated the association between the additive index of psychosocial work factors and depressive disorder and long-term sickness absence (LTSA). We assessed the onset of depressive disorder using the Major Depression Inventory at 6-month follow-up and the onset of LTSA using a national register during 12-month follow-up.

Results
For onset of depressive disorder, high exposure to any one [odds ratio (OR) 2.98], two (OR 3.14), three (OR 6.44) and all four (OR 9.62) adverse psychosocial work factors predicted a statistically significant increased risk. For onset of LTSA, high exposure to any one [hazard ratio (HR) 1.13], two (HR 1.67), three (HR 2.31) and all four (HR 4.04) psychosocial work factors predicted an increased risk. The two latter associations were statistically significant. Trend tests indicated an exposure–response relationship for both outcomes.

Conclusions
Workers reporting exposure to multiple adverse psychosocial work factors had a higher risk of developing depressive disorder and LTSA.
Musculoskeletal corticosteroid injection and risk of acute coronary syndrome: a case control study
Authors: Thomas Katharine , Schonmann Yochai 
Published: August 2023

Abstract

Background
Musculoskeletal corticosteroid injection (CSI) is a frequently used treatment, considered safe with a low incidence of minor side effects.

Objective
To investigate whether the incidence of acute coronary syndrome (ACS) is increased following corticosteroid injection for musculoskeletal conditions.

Methods
Data were reviewed from 41,276 patients aged over 40 years and hospitalised with ACS between January 2015 and December 2019. Each ACS case was allocated up to 10 control patients from their primary care clinic, matched for age and sex. The cases and controls were reviewed for orthopaedic or rheumatological consultation including a CSI procedure and occurring prior to the hospital admission date. The incidence of CSI was compared between the case and control groups.

Results
Data from a total of 413,063 patients were reviewed, 41,276 ACS cases and 371,787 controls. The mean age was 68.1, standard deviation (SD) = 13.1, 69.4% male. In the week prior to their hospital admission, 118 ACS patients were treated with CSI compared with 495 patients in the control group; odds ratio (OR) = 1.95 (1.56–2.43). In total, 98% of CSI procedures were carried out by orthopaedic specialists. An association between ACS and prior CSI was strongest in the days immediately prior to hospitalisation: OR = 3.11 (2.10–4.61) for patients who were injected 1 day before ACS. The association between ACS and CSI declined with increasing time between injection and hospital admission: at 90 days OR = 1.08 (0.98–1.18). The association remained robust when cardiovascular risk factors, history of rheumatological disease, and other co-morbidity were taken into consideration.

Conclusions
Musculoskeletal corticosteroid injection appears to substantially increase the risk of acute coronary syndrome.
Cardiac rehabilitation: pedagogical education strategies have positive effect on long-term patient-reported outcomes
Authors: Pedersen C G , Nielsen C V , Lynggaard V , Zwisler A D , Maribo T 
Published: August 2023

Abstract
This study examined whether patients attending cardiac rehabilitation (CR) based on the pedagogical strategy learning and coping (LC) led to improved health-related quality of life (HRQL), reduced symptoms of anxiety and depression and improved self-management 6 and 12 months after the completion of CR compared with patients attending CR based on the pedagogical strategy ‘Empowerment, Motivation and Medical Adherence’ (EMMA). A pragmatic cluster-controlled trial of two pedagogical strategies, LC and EMMA, including 10 primary health care settings and 555 patients diagnosed with ischaemic heart disease and referred to CR between August 2018 and July 2019 was conducted. In total, 312 patients replied to the questionnaires collected at baseline, 12 weeks, 6 months and 12 months after completing CR. Linear regression analyses adjusted for potential confounder variables and cluster effects were performed. We found clinically relevant and statistically significant improvements in HRQL, anxiety, depression and self-management after completing CR. The improvements were sustained at 6 and 12 months after the completion of CR. We found no differences between the two evidence-based patient education strategies. In conclusion, this study supports the use of evidence-based patient education strategies, but there is no evidence to suggest that one pedagogical strategy is superior to the other.
Exploring the determinants of successful implementation of a preventive mental health and wellness intervention for Afghan refugee families: a qualitative analysis
Authors: Rosenberg Julia , McDonough Ryan Patricia , Brown Camille , Schaffer Rachel , O’Brien Caroline , Ganjavi Fereshteh , Sharifi Mona 
Published: August 2023

Abstract
Many refugee children experience trauma in early childhood. Effective, tailored interventions are needed to improve refugee children’s access to preventive mental health. We interviewed refugee-serving stakeholders and parents participating in an evidence-based preventive mental health and wellness intervention adapted for Afghan refugee children and families who may have experienced trauma. Interview guide development was informed by two implementation science frameworks: the Consolidated Framework for Implementation Research and the Model for Adaptation Design and Impact. A three-person team coded transcripts via rapid qualitative analysis, and the study team reached consensus on themes. Six refugee-serving facilitators and five refugee parents discussed key determinants of successful implementation. Themes included: (i) modeling cultural humility to promote communication about emotions; (ii) needed linguistic support and referral networks to avoid miscommunications and missed communications; (iii) bridging connections between children, families and schools; (iv) different takeaways, or differing goals and expectations between facilitators and participants; and (v) timely, specific cultural considerations to overcome participation barriers. Overall, we found key determinants of successful implementation of a preventive mental health and wellness intervention for refugee children and families included adaptations to enhance cultural humility and sensitivity to cultural context while strengthening communication among facilitators, children and families.
Arginine methylation of RNA-binding proteins is impaired in Huntington’s disease
Authors: Ratovitski Tamara , Kamath Siddhi V , O'Meally Robert N , Gosala Keerthana , Holland Chloe D , Jiang Mali , Cole Robert N , Ross Christopher A 
Published: August 2023

AbstractHuntington’s disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in the HD gene, coding for huntingtin protein (HTT). Mechanisms of HD cellular pathogenesis remain undefined and likely involve disruptions in many cellular processes and functions presumably mediated by abnormal protein interactions of mutant HTT. We previously found HTT interaction with several protein arginine methyl-transferase (PRMT) enzymes. Protein arginine methylation mediated by PRMT enzymes is an important post-translational modification with an emerging role in neurodegeneration. We found that normal (but not mutant) HTT can facilitate the activity of PRMTs in vitro and the formation of arginine methylation complexes. These interactions appear to be disrupted in HD neurons. This suggests an additional functional role for HTT/PRMT interactions, not limited to substrate/enzyme relationship, which may result in global changes in arginine protein methylation in HD. Our quantitative analysis of striatal precursor neuron proteome indicated that arginine protein methylation is significantly altered in HD. We identified a cluster highly enriched in RNA-binding proteins with reduced arginine methylation, which is essential to their function in RNA processing and splicing. We found that several of these proteins interact with HTT, and their RNA-binding and localization are affected in HD cells likely due to a compromised arginine methylation and/or abnormal interactions with mutant HTT. These studies reveal a potential new mechanism for disruption of RNA processing in HD, involving a direct interaction of HTT with methyl-transferase enzymes and modulation of their activity and highlighting methylation of arginine as potential new therapeutic target for HD.
Exclusive Enteral Nutrition Alleviates Th17-Mediated Inflammation via Eliminating Mechanical Stress–Induced Th17-Polarizing Cytokines in Crohn’s-like Colitis
Authors: Geesala Ramasatyaveni , Zhang Ke , Lin You-Min , Johnson John C , Cong Yingzi , Cohn Steven , Shi Xuan-Zheng 
Published: August 2023

Abstract

Background and Aims
Exclusive enteral nutrition (EEN) with a liquid diet is the only established dietary treatment for Crohn’s’ disease (CD). However, the mechanism of action of EEN in CD is unclear. T helper 17 (Th17) immune response plays a critical role in CD. We hypothesized that EEN alleviates Th17 response by eliminating mechanical stress–induced expression of Th17-polarizing cytokines.

Methods
A rat model of Crohn’s-like colitis was established by intracolonic instillation of TNBS (65 mg/kg in 250 µL of 40% ethanol). Control rats were treated with saline. We characterized immunophenotypes and molecular changes of the colon in control and colitis rats with and without EEN treatment. Th17 differentiation was determined using coculture assays.

Results
TNBS instillation induced transmural inflammation with stenosis in the inflammation site and a marked increase of Th17-polarizing cytokines interleukin (IL)-6 and osteopontin and the Th17 cell population in the mechanically distended preinflammation site (P-site). EEN treatment eliminated mechanical distention and the increase of IL-6, osteopontin, and Th17 response in the P-site. IL-6 and osteopontin expression was found mainly in the muscularis externa. Mechanical stretch of colonic smooth muscle cells in vitro induced a robust increase of IL-6 and osteopontin. When naïve T cells were cultured with conditioned media from the P-site tissue or stretched cells, Th17 differentiation was significantly increased. Inhibition of IL-6, but not deletion of osteopontin, blocked the increase of Th17 differentiation.

Conclusions
Mechanical stress induces Th17-polarizing cytokines in the colon. EEN attenuates Th17 immune response by eliminating mechanical stress–induced IL-6 in Crohn’s-like colitis.
Group Equations With Abelian Predicates
Authors: Ciobanu Laura , Garreta Albert 
Published: August 2023

Abstract
In this paper, we begin the systematic study of group equations with abelian predicates in the main classes of groups where solving equations is possible. We extend the line of work on word equations with length constraints, and more generally, on extensions of the existential theory of semigroups, to the world of groups. We use interpretability by equations to establish model-theoretic and algebraic conditions, which are sufficient to get undecidability. We apply our results to (non-abelian) right-angled Artin groups and show that the problem of solving equations with abelian predicates is undecidable for these. We obtain the same result for hyperbolic groups whose abelianisation has torsion-free rank at least two. By contrast, we prove that in groups with finite abelianisation, the problem can be reduced to solving equations with recognisable constraints, and so this is decidable in right-angled Coxeter groups, or more generally, graph products of finite groups, as well as hyperbolic groups with finite abelianisation.
Feeding dietary fermentable fiber improved fecal microbial composition and increased acetic acid production in a nursery pig model
Authors: Zhang Gang , Zhao Jinbiao , Song Xiaoming , Yang Meiyu , Wang Haotian , Wu Yi 
Published: August 2023

Abstract
The objective of this study was to determine the fermentable fiber (FF) content of several common fibrous ingredients fed to nursery pigs, and then evaluate the effect of dietary FF level on growth performance and fecal microbial composition. In experiment 1, 54 nursery pigs were randomly allotted to be fed nine diets with six replicate pigs per diet. Dietary treatments included a corn–soybean meal basal diet and eight test diets based on a mixture of the corn–soybean meal diet and corn distillers dried grains with solubles, sunflower meal, oat bran, wheat bran, corn bran, sugar beet pulp (SBP), apple pomace (AP) or soybean hulls (SH). In experiment 2, 180 nursery pigs were housed in 30 pens (six pigs per pen) and randomly allotted to be fed five diets with different FF to total dietary fiber (TDF) ratios, which were 0.52, 0.55, 0.58, 0.61, and 0.64, respectively. Results showed that the FF content in SBP, AP, and SH was greater (P &lt; 0.01) than that in other ingredients. Water binding capacity of fibrous ingredients was positively correlated (P &lt; 0.05) to the digestibility of TDF, acid detergent fiber, and non-starch polysaccharides in test ingredients. Pigs fed the SBP, AP and SH diets had greater (P &lt; 0.05) fecal acetic acid and total short-chain fatty acids (SCFAs) concentrations compared with pigs fed other diets. Fecal acetic acid and total SCFAs concentrations were positively correlated (P &lt; 0.05) with FF content in experimental diets. Average daily weight gain and average daily feed intake of pigs quadratically increased (P &lt; 0.01) as the ratios of FF to TDF increased. Pigs in FF64% group showed higher (P &lt; 0.05) ACE index and fecal acetic acid concentration compared with pigs fed the dietary FF/TDF ratio of 0.52 to 0.61. Compared with the classification system of soluble dietary fiber and insoluble dietary fiber, FF could better describe the mechanism by which dietary fiber has beneficial effects on pig gut health.
Prediction of available energy and amino acid digestibility of Chinese sorghum fed to growing–finishing pigs
Authors: Feng Ganyi , Li Rui , Jiang Xianji , Yang Gang , Tian Mingzhou , Xiang Qiang , Liu Xiaojie , Ouyang Qing , Long Cimin , Huang Ruilin , Yin Yulong 
Published: August 2023

Abstract
Two experiments were conducted to determine digestible energy (DE), metabolizable energy (ME), as well as the standardized ileal digestibility (SID) of crude protein (CP) and amino acids (AA) in 10 sorghum samples fed to pigs. In experiment 1, 22 crossbred barrows (Duroc × Yorkshire × Landrace, Initial body weight [BW]: 70.0 ± 1.8 kg) were selected and allotted to a replicated 11 × 3 incomplete Latin square design, including a basal diet and 10 sorghum energy diets and three consecutive periods. Each period had 7 d adaptation and 5 d total feces and urine collection. The DE and ME were determined by the total collection and the difference method. In experiment 2, 22 crossbred barrows (Duroc × Yorkshire × Landrace, Initial BW: 41.3 ± 1.2 kg) that had a T-cannula installed in the distal ileum were assigned to a replicated 11 × 3 incomplete Latin square design, including an N-free diet and 10 sorghum diets. Each period had 5 d adaptation and 2 d ileal digesta collection. The basal endogenous N losses were measured by the N-free diet method. All diets in experiment 2 were added 0.30% titanium dioxide as an indigestible marker for calculating the ileal CP and AA digestibility. On an as-fed basis, the DE and ME contents in sorghum were 3,410 kcal/kg (2,826 to 3,794 kcal/kg) and 3,379 kcal/kg (2,785 to 3,709 kcal/kg), respectively. The best-fit prediction equation for DE and ME were DE = 6,267.945 − (1,271.154 × % tannin) − (1,109.720 × % ash) (R2 = 0.803) and ME = 51.263 + (0.976 × DE) (R2 = 0.994), respectively. The SID of CP, Lys, Met, Thr, and Trp (SIDCP, SIDLys, SIDMet, SIDThr, and SIDTrp) in 10 sorghum samples were 78.48% (69.56% to 84.23%), 74.27% (61.11% to 90.60%), 92.07% (85.16% to 95.40%), 75.46% (66.39% to 80.80%) and 87.99% (84.21% to 92.37%), respectively. The best prediction equations for SID of CP and the first four limiting AAs were as following: SIDCP = 93.404 − (21.026 × % tannin) (R2 = 0.593), SIDCP = 42.922 − (4.011 × % EE) + (151.774 × % Met) (R2 = 0.696), SIDLys = 129.947 − (670.760 × % Trp) (R2 = 0.821), SIDMet = 111.347 − (232.298 × % Trp) (R2 = 0.647), SIDThr = 55.187 + (3.851 × % ADF) (R2 = 0.609) and SIDTrp = 95.676 − (10.824 × % tannin) (R2 = 0.523), respectively. Overall, tannin and ash are the first and second predictors of DE and ME values of sorghum, respectively, and the tannin, EE, Trp, ash, CF, and ADF can be used as the key predictors for SID of CP and first four limiting AAs.
Iron requirements of broiler chickens as affected by supplemental phytase
Authors: Feijo Julmar Costa , Vieira Sergio Luiz , Horn Raquel Medeiros , Altevogt Walter Edmundo , Tormes Giovane 
Published: August 2023

Abstract
Iron is routinely supplemented in broiler feeds intending to prevent dietary deficiencies. The present research was conducted with the objective of assessing Fe requirements of broilers when fed supplemental phytase. A total of 1,280 1-d-old male Cobb × Cobb 500 were distributed in a 2 × 5 factorial arrangement (phytase-supplemented feeds × 5 graded increases of supplemental Fe) in 80 battery cages, eight replications of eight chicks each. The trial was replicated once. Chicks were fed a Fe-deficient diet without phytase (Fe analyzed at 31.30 ± 3.79 mg/kg) from placement to 7 d and then randomly distributed into battery cages with corresponding dieting treatments with or without phytase and graded increases of supplemental Fe. Feeds were formulated with corn and soybean meal (SBM), laboratory-grade calcium carbonate, and phosphoric acid; therefore, the vast majority of dietary Fe originated from corn and SBM (analyzed diet had 53.3 ± 1.41 mg/kg Fe). Phytase was added in excess to the producer recommendation of 1,000 FYT (4,452 ± 487 FYT/kg analyzed) such that phytate degradation was expected to be maximized. Supplemental Fe was from laboratory-grade ferrous sulfate heptahydrate (FeSO47H2O) which was increasingly added to the feeds (analyzed Fe in the supplemented feeds were: 53.3 ± 1.41, 65.5 ± 0.59, 77.2 ± 1.97, 87.6 ± 1.72, 97.7 ± 1.33 mg/kg). There were no interactions between phytase and dietary Fe for any response throughout the study (P &gt; 0.05). Supplementing phytase had no effects on Fe intake or Fe excretion, as well as on hematocrit (Ht), hemoglobin (Hb), ferritin, Fe contents in the liver or thigh muscle color (P &gt; 0.05). However, phytase-supplemented feeds produced better live performance as well as higher ileal digestible energy and Fe digestibility (P &lt; 0.05). No effects were found for dietary Fe in live performance at day 28 (P &gt; 0.05). On the other hand, increasing dietary Fe led to linear increases in Fe retention and excretion, Fe contents in livers, as well as Ht and Hb at 14 d (P &lt; 0.05). Quadratic responses (P &lt; 0.05) were observed for Hb at 21 d, serum ferritin on days 14, 21, and 28 (maximum responses were 83.3, 104.0, 91.9, and 88.3 mg/kg Fe, respectively). In conclusion, supplementing Fe adding to a total of 97.7 mg/kg dietary Fe did not affect live performance traits. However, the average of Fe-related blood parameters was maximized at 91.9 mg/kg dietary Fe. Supplementing phytase provided a significant increase in Fe digestibility.
An approximate method for calculating anisotropy parameters and reflectivity of shales with horizontal fractures
Authors: Chen Chao , Yin Xingyao , Chen Zuqing , Liu Xiaojing , Wang Jingbo 
Published: August 2023

Abstract
Shale is a typical medium of transverse isotropy with a vertical axis of symmetry (VTI), and its strong anisotropy is mainly due to the combined effect of intrinsic anisotropy and that induced by horizontal fractures. To calculate the anisotropy parameters of shale, a physical rock model is built based on Hudson's thin-coin fracture model and Schoenberg's linear-sliding model, and an approximate theoretical calculation method for Thomsen's anisotropy parameters of VTI media with horizontal fractures is proposed. These calculation results using the proposed method confirm that this anisotropy contributed to by horizontal fractures cannot be ignored to the overall anisotropy of shale. To simplify Rüger's formula that is an approximate theoretical formula for calculating the anisotropic reflection coefficients of VTI media, a new four-term approximate formula is derived in a standard reflectivity form based on Rüger's and Aki–Richards’ formulas. The simulation results of a VTI theoretical model and logging data of shale reservoirs show that there is only a small difference between the newly derived four-term formula and Rüger's formula for incidence angles &lt;40°, and the new four-term formula can correctly reveal the seismic amplitude-versus-offset (AVO) characteristics of VTI media and fully retain the corresponding anisotropic seismic responses. Compared to Rüger's formula, the proposed new formula only has four terms of unknown parameters and can directly decouple Thomsen's anisotropy parameter ε from them, which helps to alleviate the ill-posed problems of simultaneous inversion of multiple parameters and enhance its application potential in seismic inversion of VTI media as shale.