bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic challenges of heart failure with preserved ejection fraction: focus on echocardiography
Authors: Ivanova A. A. , Dzhioeva O. N. , Lavrenova E. A. , Rogozhkina E. A. , Drapkina O. M. 
Published: June 2023

Aim. To assess the features of diagnosing heart failure with preserved ejection fraction (HFpEF) using echocardiographic markers and diastolic stress test (DST) according to a survey of ultrasound and functional diagnostics specialists in the Russian Federation.Materials and methods. As part of the study, an anonymous survey of 155 ultrasound and functional diagnostic specialists from various Russian regions was conducted. We proposed to answer whether they routinely assess certain echocardiographic parameters necessary for diagnosing HFpEF. The specialists also indicated whether they conduct DST and whether they have the opportunity to refer the patient to this study.Results. A frequency analysis of the responses received was carried out. In routine practice, 83,2% of specialists measure the left ventricular (LV) ejection fraction by Simpson method, 76,1% — by Teichholz method. In addition, 80% of responders analyses LV mass index, 76,1% — relative LV wall thickness, 60% — tricuspid annular plane systolic excursion, 56,8% — left atrial volume index, 51.6% — E/e´ ratio, 94,8% — pulmonary artery systolic pressure, left ventricular global longitudinal strain — 16,1%, 7,7% — left atrial longitudinal strain. Also, 9,7% of specialists conduct DST on their own, while 41,3% have the opportunity to refer patients.Conclusion. The low assessment rate of some ultrasonic HFpEF mar­kers and DST among functional diagnostics specialists in the Russian Federation reduces the detection rate of HFpEF. It is necessary to develop diagnostic algorithms based mainly on clinical and anam­nestic data and available for use by doctors of any specialty.
Impact of a multidisciplinary approach and patient routing on the outcomes of treatment of patients with hepatocellular cancer
Authors: Petkau V. V. , Bessonova E.  N. , Breder V. V. , Tarkhanov A.  A. , Kiseleva K. E. 
Published: June 2023

Introduction: Hepatocellular cancer (HCC) is the sixth most common form of cancer worldwide and the third most common cause of cancer death. The long-term results of treatment are influenced by organizational decisions aimed at increasing the availability of specialized care. The purpose of our study is to evaluate the impact of rerouting and the introduction of a multidisciplinary approach on overall survival (OS) of patients with HCC. Materials and methods. A retrospective study was conducted to study the treatment tactics and results of treatment in all patients with HCC registered in the Sverdlovsk Regional Oncological Cancer Registry with a diagnosis of HCC from 2015 to 2021. A comparative analysis was carried out in 3 groups of patients: the control group, before changes, group of patients after changes in routing, and a group of patients with multidisciplinary approach involving a gastroenterologist/hepatologist and an interventional oncologist.Results: There is an increase in the number of patients who received advice from an oncologist and referred for specialized treatment: 12.0 %, 19.5 % and 34.9 %, respectively (p < 0.001). Median OS increased significantly only in the multidisciplinary approach group of 3.1 versus 2.2 months (p = 0.002). Low overall survival rates are associated with a large proportion of late stages. A significant increase in OS was registered in the group of patients with BCLC C stage: from 3.4 months to 12.5 months (p = 0.046).Conclusions: Simplifying the patient's route from a gastroenterologist to an oncologist shortens the time to treatment start, increases the number of patients who receive advisory assistance in an oncological dispensary, but does not affect OS. A multidisciplinary approach allows more patients to receive specialized care. At the same time, the maximum effect on OS is noted at the BCLC C stage.
Meta-analysis of studies on the effectiveness of adding anti-PD1 antibodies to the first-line chemotherapy in advanced esophageal cancer
Authors: Fedyanin M. Yu. , Tryakin A. A. , Rays A. B. , Kononets P. V. , Abou-Haidar O. B. , Gladilina I. A. , Malikhova O. A. , Tyulyandin S. A. , Stilidi I. S. 
Published: June 2023

Introduction: The results of six randomized control trials have been published by 2022, which evaluated the efficacy of adding PD-1 inhibitors to the first-line chemotherapy in patients with metastatic esophageal cancer. However, it still remains unclear which patients derive the most clinical benefit from combined therapy. Therefore, it is necessary to evaluate the efficacy of the combination of anti-PD1 treatment with chemotherapy in different patient subgroups.Materials and methods: We conducted a meta-analysis of randomized controlled trials in patients with stage IV esophageal cancer who received anti-PD1 drugs with different chemotherapeutic regimens in the first-line setting to select patients who benefit the most from the combined therapy.Results: Six randomized trials were included in the analysis for a total of 3,813 patients. Patients who received combination therapy had significantly longer OS (HR = 0.69, 95% CI: 0.63-0.75; p < 0.001), PFS (HR = 0.62, 95% CI: 0.56-0.69; p < 0.001), and better ORR (OR = 2.12, 95% CI: 1.85-2.42; p < 0.001) than those who received chemotherapy alone. Subgroup analyses showed no benefit of adding PD1-inhibitors to chemotherapy in patients with PD-L1 CPS <1 in terms of OS (HR = 0.58, 95 % CI: 0.31-1.1; p = 0.1) as well as in never-smokers (HR = 0.9, 95% CI: 0.67-1.23; p = 0.52).Conclusions: The addition of PD-1 inhibitors to the first-line chemotherapy in patients with metastatic esophageal cancer significantly improves treatment outcomes. Our results could not strongly suggest the selected patients' cohort which would benefit the most from the combination of PD-1 inhibitors and chemotherapy use.
Organ preservation treatment of patients with atypical hyperplasia and endometrial cancer: current trends
Authors: Petrozhitskaya A.  A. , Tandelov R.  K. , Zaitcev N.  A. , Morkhov K.  Yu. 
Published: June 2023

The high prevalence and steady increase in the incidence of endometrial cancer dictate the need to prevent and improve the effectiveness of treatment of this disease. The solution of these issues is possible either by expanding the indications for surgical treatment in endometrial proliferative processes, or by improving conservative methods of therapy, which is of priority importance, since some patients often have the question of preserving reproductive function.Leading oncogynecological communities have come to a consensus: conservative treatment with preservation of fertility is possible and safe for young patients with endometrioid endometrial cancer of a high degree of differentiation, limited to endometrial damage only. According to published studies, the use of progestins gives a high frequency response to treatment in patients with atypical hyperplasia and early endometrial cancer. Combined treatment methods, including the use of metformin or hysteroscopic resection after drug therapy, can reduce the frequency of relapses.In the absence of larger prospective studies, it is very important to consider a woman's overall health and fertility potential before recommending conservative treatment for early endometrial cancer. It is necessary to conduct further randomized controlled trials in order to provide more convincing evidence of the benefits of a particular technique.
Development and Testing of a Mathematics Learning Application
Authors: Fadlil Arif Ahmad , Purbohadi Dwijoko , Riyadi Slamet 
Published: June 2023

Distance learning, or online learning, is essential for both teachers and students as they work to create a system of education to function during a pandemic. Therefore, this research aims to develop a CAI media-based learning application for teaching fractions in mathematics. The survey results conducted at SDN 1 Sukerejo Boyolali revealed that students encountered the most trouble with fractions. Hence, their comprehension of the mathematics learning application was evaluated. The pre-test and post-test results of 30 students in both the control and experiment classes demonstrated that the application was easier to use than direct or traditional learning methods.
Aspek Hukum Perdata dalam Kontrak Bisnis Pariwisata dan Dampak Untuk Pembangunan Ekonomi di Indonesia
Authors: Perwira I Nyoman Satria , Handayani I Gusti Ayu Ketut Rachmi , Karjoko Lego 
Published: June 2023

The tourism sector is experiencing a very rapid development by giving birth to various variations of tourism business activities. Where this tourism business activity sometimes experiences problems in carrying out tourism business contracts. This study aims to analyze the civil law aspects of tourism business contracts in Indonesia and the impact of tourism business on economic development in Indonesia. This research is a normative research, prescriptive, with a regulatory and conceptual approach. The results of the study found that a) Aspects of civil law in the tourism business in Indonesia have an important role in it As we know tourism has tourist activities whose activities are a business. It is undeniable that a business relationship starts from a contract. In the absence of a contract, it is impossible for a business relationship to be carried out in which there is an agreement regulated in article 1313 of the Civil Code (Civil Code) known as an agreement. And b) The impact of the tourism business on economic development in Indonesia in general, the greater the contribution of the tourism sector to the economy of a region, the greater the contribution of the tourism sector in improving the economic welfare of the people in the region.
Neurofibroma of Adrenal gland- A rare case report
Authors: N Ankita , K Nagarekha , Shanthi M , Shashirekha Patil 
Published: June 2023

Neurofibroma of the adrenal glands is rare, most common site of presentation are head and neck region and along the nerves. With the us of computed tomography , magnetic resonance imaging , an ultrasonography for the detection of adrenals masses is increasing. On computed tomography neurogenic tumours frequently appear as a distinct, smooth or lobulated mass. All varieties of neurogenic tumours may exhibit calcification But for confirmation of the lesion histopathological examination and immunohistochemistry is a must. Neurofibroma of adrenals although rare but a possibility. Immunohistochemistry plays an important role in confirming the diagnosis. IHC helps in definitive diagnosis which helps clinicians with management of the patient.
Estudo da prevalência da infecção puerperal no hospital maternidade de referência do município de Juazeiro do Norte - CE
Authors: Santana Ana Paula Nascimento de , Santana Cícera Érica Nascimento , Tavares Maria Jeanne De Alencar 
Published: June 2023

<p>Infecção puerperal é aquela que se origina no aparelho genital, após parto recente. Com o objetivo de analisar a incidência e prevalência de infecção puerperal, analisou-se 303 prontuários de puérperas atendidas na maternidade durante o ano de 2009, onde 57 correspondiam à infecção puerperal. Elaborou-se um estudo exploratório, documental, retrospectivo. Utilizou-se um roteiro para a coleta de dados e constatou-se um elevado percentual de puérperas na faixa etária entre 16 e 20 anos (28%), sendo 44% primigesta. A via de parto mais prevalente foi a cesariana (60%), sendo que a maioria (53%) ocorreu pelo risco materno-fetal. Internação, a maioria (53%) por 24 horas após o parto, 48 horas (44%) e 72 horas (3%). Após a alta, 16% voltaram a maternidade antes das 24 horas. Diagnósticos: Endomiometrite (36%), infecção do períneo 17%, períneo vulvovaginite-cervicite 3%, infecções da ferida operatória 23% e mastite 21%. Os antibióticos profiláticos utilizados foram: Cefalotina (39%) e Metronidazol (36%), para o tratamento da infecção Cefalotina (53%), Metronidazol (9%) e Cefalexina (38%). Conclui-se que a incidência e prevalência de infecção puerperal devem-se a maior parte devido ao alto índice de partos cesáreos na unidade, os outros fatores podem estar relacionados à assistência, uso de antibióticos e outras causas.</p>
Matemática e multiplicação: dificuldades e novos olhares em torno deste ensino
Authors: Pires Maria José Da Silva , Abrantes Nyedja Nara Furtado de , Borba Valéria Maria De Lima 
Published: June 2023

<p>Este trabalho, como ponto de partida para discussões sobre a matemática e as dificuldades dos educandos no processo de resolução de problemas em multiplicação, no 4º ano do Ensino Fundamental I, tem a finalidade de identificar as principais dificuldades destes alunos neste processo, bem como, a partir das informações coletadas, apresentar uma análise para compreendermos como tem sido a prática das professoras, tecendo considerações sobre estratégias para o desenrolar de um ensino dinâmico e proveitoso nesta área, supostamente, complexa e difícil. Os dados obtidos do questionário aplicado com as duas professoras, sujeitos desta pesquisa, estando inseridas na Escola Pública, uma na cidade de Sousa/PB e a outra em Cajazeiras/PB, serviram para confrontação e, ao mesmo tempo, reflexão dos estudos teóricos sobre a temática e prática das mesmas. Constatamos que as dificuldades existem quanto à resolução de problemas em multiplicação, porém, as mesmas muitas vezes advêm de um ensino mecânico e tradicional.</p>
SimpleWay process: parceria entre academia e indústria através de engenharia de software aplicada a projetos reais
Authors: Rodrigues Nadja Da Nóbrega , Estrela Naylla Vieira de Almeida 
Published: June 2023

<span>Entendendo a necessidade de integração entre academia e indústria, este artigo relata a estratégia de uso de recursos técnicos de uma Empresa Júnior (EJ) da Área de Ciência da Computação enquanto instrumentos para ensino e aprendizagem de Engenharia de Software aplicada. A metodologia associada ao estudo baseou-se no uso de um Processo de Desenvolvimento de Software (PDS) específico, desenvolvido para a EJ, e do ambiente criado para este PDS, como instrumentos na instanciação de projetos reais da EJ ou fictícios, em sala de aula. As principais contribuições do uso do PDS e do seu ambiente foram o aumento na qualidade dos projetos e o valor agregado aos alunos, através da utilização de boas práticas da indústria.</span>
فعالية إستراتجية قوّة اثنين في تعليم معارة الاستماع ومهارة الكتابة في مدرسة مفتاح العلوم الابتدائية الإسلامية لامونجان
Authors: Ningrum Amaliyah Herawati Puji 
Published: June 2023

ABSTRACT
The purpose of this study was to know the use, to know supporting and inhibiting factors and to know the effectiveness of the power of two strategy in listening skill and writing skill learning at Miftahul Ulum islamic elementary school Lamongan. This study uses a qualitative approach and quantitative approach. This study uses the experimental method, the type of design is pre-experimental design. with a one-group pretest-posttest design model. Data collection techniques in the form of tests, interviews and observation. The research subjects were all fourth grade students of Miftahul Ulum islamic elementary school Lamongan. The results of this study indicate that the application of the power of two strategy in listening skill learning is effective. Evidenced in the average value of students. Average score from the pretest value of 66.79 and the posttest value of 82.04. And from the results of the paired sample t-test, the t table value 8,006 is greater than the t tabel value 2,052, which concludes that is rejected and is accepted. So it can be said that there is an effectiveness of the power of two strategy in listening skill and writing skill learning at Miftahul Ulum islamic elementary school Lamongan.
مستخلص البحث
أهداف البحث هم لتعريف استخدام إستراتجية قوة اثنين، ولتعريف عوامل الداعمة والعائقة إستراتجية قوة اثنين، ولتعريف فعالية إستراتجية قوة اثنين في تعليم مهارة الاستماع ومهارة مهارة الكتابةفي مدرسة مفتاح العلوم الابتدائية الإسلامية لامونجان. استخدم هذا البحث المدخل النوعي والكمي الوصفي. طريقة تجريبية مع نوع التصميم pra-experiment design، بتصميم مجموعة واحدة باختبارالقبلي والبعدي (one-group pretest-posttest design). طريقة جمع البيانات هم الاختبار، مقابلة وملاحظة. المبحوث في هذا البحث الجامعي يعني تلاميذ في الفصل الرابع مدرسة مفتاح العلوم الابتدائية الإسلامية لامونجان. نتائج هذا البحث أن استخدام إستراتجية قوة اثنين (The Power Of two) في تعليم مهارة الاستماع ومهارة الكتابة فعلية. قيمة المتوسط من متوسط ​​قيمة اختبار القبلي 66.79 ومتوسط ​​قيمة اختبار البعدي 82.04. من حصّل الاختبار Paired Sampel T-Test أن ظهر قيمة (t hitung) 8.006 و (t tabel) 2 ،052 والتي توضح أن قيمة (t hitung) أكبر من قيمة (t tabel). هذا يدل على فرضية مرفوض و مقبول. لذلك تم كان فعالية إستراتجية قوة اثنين (The Power Of Two) في تعليم مهارة الاستماع ومهارة الكتابة في مدرسة مفتاح العلوم الابتدائية الإسلامية لامونجان.
الكلمات الإشارية : إستراتجية قوة اثنين، مهارة الاستماع، مهارة مهارة الكتابة
The صعوبات التعلم مهارة في القراءة لتلاميذ الصف العاشر في المدرسة الثانوية الإسلامية الحكومية 5 جومبانج
Authors: Aini Hanifah Qurotul 
Published: June 2023

Kesulitan belajar pada keterampilan membaca adalah hambatan ketika proses mengingat atau memahami apa yang dibaca yang dialami oleh siswa ketika pembelajaran bahasa arab. Sebagian besar siswa yang mengalami kesulitan belajar dalam membaca, dapat mengakibatkan masalah lain dalam memahami materi pelajaran bahasa arab. Tujuan penelitian ini adalah (1) Untuk mengetahui tingkat kesulitan belajar keterampilan membaca (Maharah Al Qira’ah) pada siswa kelas Madrasah Aliyah Negeri 5 Jombang, (2) Untuk mengetahui faktor – faktor yang dapat mempengaruhi kesulitan belajar keterampilan membaca (Maharah Al Qira’ah) pada siswa kelas X Madrasah Aliyah Negeri 5 Jombang dan solusinya. Dalam penelitian ini peneliti menggunakan pendekatan deskriptif kualitatif. Pengumpulan data dilakukan dengan wawancara, observasi dan tes. Setelah data di peroleh, kemudian di analisis dengan mereduksi data, menyajikan data dan memverifikasi atau menarik kesimpulan . Kesulitan belajar keterampilan membaca (Maharah Al Qira’ah) yang dialami siswa adalah kesulitan pada pengucapan Bahasa Arab, dialek Bahasa Arab, tata Bahasa Arab (qawaid), dan pemahaman bacaan. Hasil penelitian menunjukkan: (1) Tingkat kesulitan Belajar Bahasa pada pada tata Bahasa Arab (qawaid) 79% , pengucapan Bahasa Arab 67%, pada dialeg Bahasa Arab 67%, pada pemahaman bacaan 26%. (2) Faktor kesulitan belajar keterampilan membaca (Maharah Al Qira’ah) ada dua, yaitu faktor internal dan faktor eksternal. Faktor internal meliputi kurangnya minat siswa, latar belakang siswa berbeda – beda, pengalaman dan kompetensi bahasa yang dimiliki siswa yang rendah. Faktor eksternal meliputi faktor guru, faktor media pembelajaran, faktor metode pembelajaran, dan faktor lingkungan.
Kata-Kata Kunci: Kesulitan Belajar, Keterampilan membaca (Maharah Al Qira’ah)
وسيلة بادليت في تعليم المفردات العربية في المدرسة الابتدائية الإسلامية الأهلية محمدية 18 سومبريجو
Authors: Hajidah Lucy 
Published: June 2023

ملخص
بعد البحث فإن المشكلة التي تنشأ في عملية تعليم مفردات البسمة العربية في المدرسة الابتدائية الإسلامية الأهلية محمدية ثمانية عشر سومبريجو، وهي معرفة معنى المفردات التي تم سجنها منخفضة نسبيا، ويجدون صعوبة في فهم معنى المفرودات. ومن هنا قرر الباحث استخدام وسيلة تعليمية تتطور اليوم، وهي وسيلة البادليت في تعليم المفرودات بهدف أن يتمكن التلاميذ من تقوية ذاكرتهم للمفرودات التي تم تعلمها وتحسين إتقانهم للمفرودات، خاصة فيما يتعلق بحفظ المفرودات ومعنى المفردات العربية. الأهداف من هذه البحث هو لمعرفة فعالية وسيلة بادليت في تعليم فهم معاني المفردات العربية. طريقة البحث المستخدمة هي استخدام المنهج التجريبي مع النوع شبه التجريبي. مع مصادر البيانات في هذه الدراسة هم مدير ومعلمي وتلاميذ الفصل السادس في المدرسة الابتدائية، والعينة المستخدمة في هذه الدراسة هي الفصل السادس (أ) كفصل تجريبي والفصل السادس (ب) كفصل ضابط. في حين أن الطرق المستخدمة في جمع البيانات هي الاختبار والملاحظة. أما بالنسبة لتقنيات تحليل البيانات باستخدام اختبار التطبيع واختبار التجانس، فهي مستمرة مع اختبار الفرضيات باستخدام اختبار N-Gain واختبار Man Whitney بسبب بيانات غير طبيعية. فإن نتائج اختبار Man Whitney لتعليم فهم معاني المفردات القيمة، وهي sig. 0،000<0,05 ، من هذه القيمة يوجد فرق كبير بين استخدام وسيلة بادليت والتعليم التقليدي بحيث يمكن تفسير أن التعليم باستخدام وسيلة بادليت فعال في تعليم فهم معاني المفردات، لذلك يمكن استنتاج الفرضية أن Ho مرفوض وHa مقبول.
الكلمة الأساسية :وسيلة بادليت، تعليم المفردات

ABSTRAK
Masalah yang muncul dalam proses pembelajaran kosa kata bahsa arab di MI Muhammadiyah 18 Sumberrejo yaitu mengetahui makna mufrodat yang sudah diajarakan masih relatif rendah, serta mengalami kesulitan dalam memahami makna mufrodat. Dengan demikian, peneliti memutuskan untuk menggunakan media pembelajaran yang berkembang pada zaman sekarang yaitu aplikasi Padlet dalam pembelajaran mufrodat dengan tujuan agar siswa dapat memperkuat memori mereka mengenai mufrodat yang telah dipelajari khususnya dalam hal pemaknaan kosa kata bahasa arab. Tujuan dari penelitian ini adalah untuk mengetahui keefektifitasan Aplikasi Padlet dalam pembelajaran pemahaman makna kosa kata bahasa arab. Metode penelitian yang digunakan dalam penelitian ini adalah dengan menggunakan Metode Eksperimen dengan jenis Quasi Eksperimen. Dengan sumber data dalam penelitian ini adalah kepala sekolah, guru dan siswa kelas VI, sampel yang di gunakan dalam penelitian ini adalah kelas VI A yang sebagi kelas eksperimen dan kelas VI B sebagai Kelas Kontrol. Sedangkan untuk pengumpulan data mengunakan tes dan Observasi. untuk teknik analisis data menggunakan uji normalisa dan uji homogenitas di lanjutkan dengan uji hipotesis menggunakan uji N-Gain dan uji man whitney karena data tidak normal. Hasil uji man whitney pembelajaran pemahaman kosa kata memiliki nilai yaitu sig. 0,000<0,05, dari nilai tersebut dapat di arti bahwa pembelajaran menggunakan aplikasi padlet efektif dalam pembelajaran pemahaman kosa kata bahasa arab, Jadi hipotesis dapat di simpulkan bahwa Ho ditolak dan Ha diterima.
Kata Kunci : Media Padlet, Pembelajaran Kosakata.
AUTHENTIC HAPPINESS OF NUN WHO HAVE MUSLIM PARENTS
Authors: Riskasari Windah 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui gambaran kebahagiaan otentik biarawati yang memiliki orang tua muslim. Responden dalam penelitian ini terdapat tiga orang biarawati dari Kongregasi Puteri Kasih. Karakteristik responden adalah sudah memasuki masa bina lanjut dan memiliki latar belakang orang tua muslim. Penelitian menggunakan pendekatan kualitatif dengan metode penelitian fenomenologi. Berdasarkan hasil dan analisis data dipahami bahwa gambaran kebahagiaan otentik biarawati dapat dilihat dari bagaimana hidup religius yang dipilih yaitu menjadi biarawati mampu membuat biarawati bersyukur atas pilihan kehidupan yang dijalaninya dan memutuskan untuk setia dengan Tuhan sampai akhir hayat. Perasaan syukur muncul dari bagaimana subyek menikmati hidup panggilannya yang dirasa penuh dengan berkat dari Tuhan. Pilihan hidup membiara yang terus dijalani dengan dukungan dari keluarga membiasakan subyek melakukan aktivitas bersama dengan orang banyak membuat munculnya sikap-sikap keseharian yang menunjukkan adanya kekuatan khas dan kebijakan personal yang ditampilkan dalam bentuk perilaku dari kearifan dan pengetahuan, keberanian, kemanusiaan dan cinta, keadilan, kesederhanaan, serta transendensi yang dimiliki subyek.
Hydrothermal Synthesis of Hematite (α-Fe2O3) from Indonesia Iron Sand
Authors: Furqonul Hakin Al Hadi  , Tanti Haryati  , Novita Andarini  , Suwardiyanto  , Sulistiyo Yudi Aris 
Published: June 2023

High potency of Indonesian iron sand can be optimized by transforming to valuable iron oxide product namely Hematite (α-Fe2O3). Hydrothermal synthesis was carried out to transform iron oxide phase to hematite that can be analyzed by x-ray diffraction method. Utilization of ion sand as raw material produced multyphase in product reaction, while the usage of Fe(OH)x that extracted from iron sand attained high purity of hematite. The best conditions of reaction were at 160 oC for 24 h. Higher temperature and longer time reaction transformed α- α-Fe2O3 to be γ-Al2O3 and Fe3O4 as more stable phase.