bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical guideline highlights for the hospitalist: 2022 American Heart Association/American Stroke Association Guideline for the management of patients with spontaneous intracerebral hemorrhage
Authors: Burroughs‐Ray Desirée C. , VanDillen Ariana F. , Jackson Christopher D. 
Published: February 2023

GUIDELINE TITLE2022 Guideline for the Management of Patients with Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke AssociationRELEASE DATEMay 2022PRIOR VERSIONGuidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association 2015DEVELOPERAmerican Heart Association and American Stroke AssociationFUNDING SOURCENoneTARGET POPULATIONAdult Patients with Spontaneous Intracerebral Hemorrhage
脂漏性角化症が侵入門戸と考えられた破傷風の1例(A case of tetanus in which the portal of entry was presumed to be seborrheic keratosis)
Authors: 詩乃 髙橋 , 加奈子 竹重 , 理夫 服部 , 雄二郎 濱野 , 泰 上條 , 浩 今村 
Published: February 2023

要旨87歳の男性が開口障害，嚥下困難のため経口摂取不能となり，他院に入院した。入院後から徐々に刺激による下肢の痙攣，筋緊張が出現し，気道閉塞による一過性の呼吸停止があり，当院へ転院搬送された。破傷風と診断し，破傷風トキソイド，破傷風免疫グロブリン，ペニシリンGを投与し，人工呼吸器管理および筋弛緩薬，鎮静薬，鎮痛薬，マグネシウム製剤などで全身管理を行った。明らかな外傷はなかったが，右前胸部の脂漏性角化症に浸出液を認めたため培養に提出したところ，Clostridium tetaniが検出され，腫瘤を切除した。経過は良好であり，気管切開孔を閉鎖し，リハビリ継続目的に転院した。脂漏性角化症が侵入門戸となって破傷風を発症した症例は，過去に報告されていない。破傷風は本邦では高齢者に多い疾患であり，高齢者には脂漏性角化症がほぼ必発である。また破傷風の治療においては，侵入門戸を検索し，必要があれば処置を行わなければならない。したがって，高齢者にごくありふれた疾患である脂漏性角化症が，Clostridium tetaniの侵入門戸となりうるということを，救急医が認識することは極めて重要と考える。
Improving Noninvasive Classification of Molecular Subtypes of Adult Gliomas With Diffusion‐Weighted MR Imaging: An Externally Validated Machine Learning Algorithm
Authors: Guo Yang , Ma Zeyu , Pei Dongling , Duan Wenchao , Guo Yu , Liu Zhongyi , Guan Fangzhan , Wang Zilong , Xing Aoqi , Guo Zhixuan , Luo Lin , Wang Weiwei , Yu Bin , Zhou Jinqiao , Ji Yuchen , Yan Dongming , Cheng Jingliang , Liu Xianzhi , Yan Jing , Zhang Zhenyu 
Published: February 2023

BackgroundGenetic testing for molecular markers of gliomas sometimes is unavailable because of time‐consuming and expensive, even limited tumor specimens or nonsurgery cases.PurposeTo train a three‐class radiomic model classifying three molecular subtypes including isocitrate dehydrogenase (IDH) mutations and 1p/19q‐noncodeleted (IDHmut‐noncodel), IDH wild‐type (IDHwt), IDH‐mutant and 1p/19q‐codeleted (IDHmut‐codel) of adult gliomas and investigate whether radiomic features from diffusion‐weighted imaging (DWI) could bring additive value.Study TypeRetrospective.PopulationA total of 755 patients including 111 IDHmut‐noncodel, 571 IDHwt, and 73 IDHmut‐codel cases were divided into training (n = 480) and internal validation set (n = 275); 139 patients including 21 IDHmut‐noncodel, 104 IDHwt, and 14 IDHmut‐codel cases were utilized as external validation set.Field Strength/SequenceA 1.5 T or 3.0 T/multiparametric MRI, including T1‐weighted (T1), T1‐weighted gadolinium contrast‐enhanced (T1c), T2‐weighted (T2), fluid attenuated inversion recovery (FLAIR), and DWI.AssessmentThe performance of multiparametric radiomic model (random‐forest model) using 22 selected features from T1, T2, FLAIR, T1c images and apparent diffusion coefficient (ADC) maps, and conventional radiomic model using 20 selected features from T1, T2, FLAIR, and T1c images was assessed in internal and external validation sets by comparing probability values and actual incidence.Statistical TestsMann–Whitney U test, Chi‐Squared test, Wilcoxon test, receiver operating curve (ROC), and area under the curve (AUC); DeLong analysis. P < 0.05 was statistically significant.ResultsThe multiparametric radiomic model achieved AUC values for IDHmut‐noncodel, IDHwt, and IDHmut‐codel of 0.8181, 0.8524, and 0.8502 in internal validation set and 0.7571, 0.7779, and 0.7491 in external validation set, respectively. Multiparametric radiomic model showed significantly better diagnostic performance after DeLong analysis, especially in classifying IDHwt and IDHmut‐noncodel subtypes.Data ConclusionRadiomic features from DWI could bring additive value and improve the performance of conventional MRI‐based radiomic model for classifying the molecular subtypes especially IDHmut‐noncodel and IDHwt of adult gliomas.Level of Evidence3.Technical EfficacyStage 2.
Novel carbon nanotube field effect transistor based dual output second‐generation current conveyor: Design and applications
Authors: Jogad Seema , Loan Sajad A. , Afzal Neelofer 
Published: February 2023

AbstractIn this work, we propose, design and simulate a new configuration of Class AB dual output (DO) second‐generation current conveyor (DO‐CCII). Two versions of this new DO‐CCII configuration are proposed: one employing 32 nm technology‐based carbon nanotube field effect transistor (CNTFET) and the other employing the conventional complementary MOS (CMOS). The HSPICE simulation studies have been performed to evaluate key performance parameters like current and voltage gains, voltage and current bandwidths (BW), the port X and Y resistances, total harmonic distortion of both proposed DO‐CCII configurations. It has been seen that ~388× and ~215× improvement in current and voltage BWs respectively have been achieved in the proposed CNTFET based DO‐CCII (CNTFET‐DO‐CCII) configuration in comparison to its CMOS counterpart (CMOS‐DO‐CCII). Similarly, desired port X and Y resistances have resulted substantially in the CNTFET based DO‐CCII configuration. Further, to evaluate the performance of proposed DO‐CCIIs, some applications such as sinusoidal oscillator, integrator and differentiator have been simulated and compared. In the designed oscillators, the effect of temperature on oscillating frequency has also been studied. A temperature insensitive behavior has been seen in the CNTFET‐DO‐CCII for a wide frequency range. Furthermore, it has been found that the optimization of number of CNTs, CNT diameter and inter‐CNT pitch of CNTFETs improve the performance of the proposed DO‐CCII.
Grapevine red blotch virus alters grape skin cell‐wall composition impacting phenolic extractability during winemaking
Authors: Rumbaugh Arran , Medina‐Plaza Cristina , Sudarshana Mysore R. , Oberholster Anita 
Published: February 2023

AbstractBACKGROUNDGrapevine red blotch virus (GRBV) is the causal agent of grapevine red blotch disease and is known to delay grape ripening. However, grape cell‐wall modifications during GRBV infection are largely unknown, even though the cell wall plays a large role in pathogenicity, viral interactions with host plants, and phenolic extractability during winemaking. Understanding the impact of GRBV infection on cell‐wall metabolism is important for the development of potential mitigations strategies. In this study, high‐throughput transcriptome sequencing was conducted on Vitis vinifera L. ‘Merlot’ grapes during ripening. The cell‐wall composition, phenolic content, and phenolic extractability at two different commercial harvest points were also determined.RESULTSLog fold changes indicated a strong induction in diseased grapes at harvest of several transcripts involved in cell‐wall solubilization and degradation. However, these observations did not translate to changes in cell‐wall composition at either harvest point in diseased grapes, potentially suggesting post‐transcriptional regulation. Moderate induction of pectin methylesterase inhibitor transcripts and transcripts associated with pathogenesis‐related proteins coincided with increases in pectin and soluble proteins in cell walls of diseased grapes at harvest. Both pectin and pathogenesis‐related proteins are known to retain phenolic compounds during winemaking.CONCLUSIONOur study corroborates this finding when the percentage extractability of flavonols in wines was significantly lower when made from GRBV‐infected fruit. These results suggest GRBV alters the grape cell walls, consequently decreasing phenolic extraction during winemaking. © 2023 Society of Chemical Industry.
Characteristics of Adults Undergoing Soft Tissue and Orthognathic Surgery for Obstructive Sleep Apnea
Authors: Durr Megan , Darbinian Jeanne , Ramirez Kimberly , Swisher Austin R. , Block‐Wheeler Nikolas R. 
Published: February 2023

ObjectiveTo identify clinical and demographic characteristics of adults with obstructive sleep apnea (OSA) undergoing soft tissue and orthognathic sleep surgery, assess temporal trends in surgery type and proportion of women undergoing surgery, and provide clinical perspective before wide‐spread implementation of hypoglossal nerve stimulation (HGNS).MethodsIn a retrospective cohort study, adults diagnosed with OSA from 2009 to 2016 were identified in a large integrated healthcare system. Characteristics between cohort members who did and did not undergo sleep surgeries were compared. Multivariable logistic regression models examined associations of different characteristics with whether surgery was performed.ResultsOf 172,216 adults with OSA, 2,262 (1.3%) underwent sleep surgery during 2009–2017. The most common sleep surgery was palate surgery (56.9%), which decreased proportionately over time. In multivariable analysis, older age and obesity were associated with lower odds of undergoing surgery. Those who underwent tonsillectomy and adenoidectomy were more likely to have larger tonsils and not require additional surgery, whereas tongue reduction recipients were more likely to have severe OSA and require multiple surgery types. The proportion of women undergoing surgery increased over time (p < 0.001 from trend test).ConclusionClinical and demographic characteristics associated with soft tissue and orthognathic sleep surgery were identified in a large adult cohort prior to widespread implementation of HGNS. An increase in sleep surgery among women and a decrease in palate surgery over time were observed. The findings provide clinical perspective on sleep surgery performed prior to implementation of HGNS and may inform future studies examining its associations with patient characteristics.Level of Evidence3 Laryngoscope, 133:1262–1270, 2023
“Smart” Stimuli‐responsive Injectable Gels for Bone Tissue Engineering Application
Authors: Li Hanke , Hao Zhuowen , Zhang Shuwei , Li Beihai , Wang Yi , Wu Xinxin , Hu Yingkun , Chen Renxin , Chen Tianhong , Li Jingfeng 
Published: February 2023

AbstractBone grafting, as the current gold‐standard for large scaled bone damage of various causes, has faced challenges from both the source and appliance. Emerging new tissue engineering substitutes are demonstrating more options and possibilities, with their improved biocompatibility, accessibility, and customizable function. Amongst them, injectable gels (IGs) are a class of gel material displaying astonishing non‐invasive properties and surgical viability. While possessing responsiveness toward specific stimuli, they change their physical form in vivo, thus serving as wonderful biomaterials and drug delivery systems. In this review, the mechanics of stimuli‐responsive IGs developed during the past decade are illustrated. Two branches of crosslinked gels – co‐valent and non‐covalent crosslinked IGs and their composition and customization are introduced. In conclusion, the present trend in bone tissue engineering research is summarized and made an outlook for future. It is hoped that this comprehensive review can provide a proper reference for the development of new IGs.
Massage therapy for children, adolescents, and young adults: Clinical delivery and effectiveness in hematology and oncology
Authors: Rodgers‐Melnick Samuel N. , Bartolovich Mandy , Desai Neha J. , Vasanna Smitha Hosahalli , Rivard Rachael L. , Owusu‐Ansah Amma , Ahuja Sanjay P. , Dusek Jeffery A. , Miller David W. 
Published: February 2023

AbstractBackgroundChildren, adolescents, and young adults with hematologic and/or oncologic conditions experience multiple, significant symptoms (e.g., pain, stress, and anxiety), which may be addressed by nonpharmacologic approaches such as massage therapy (MT). The purpose of this study was to describe the clinical delivery of MT provided by a certified pediatric massage therapist and assess effectiveness in two patient groups: those with sickle cell disease (SCD) or hematologic and/or oncologic conditions excluding SCD (HemOnc).MethodsInvestigators conducted a retrospective review of MT sessions provided to patients 0–39 years with hematologic and/or oncologic conditions at a large pediatric academic medical center.ResultsBetween October 2019 and December 2021, 3015 MT sessions were provided to 243 patients (171 HemOnc; 72 SCD) and documented in the electronic health record. Patients (mean age: 12.21 ± 7.19 years) were generally White (49.4%) or Black/African American (43.2%), non‐Hispanic (94.2%), and 52.3% female. Patients in the SCD group (vs. patients in the HemOnc group) reported significantly higher (p < .05) pretreatment pain (6.95 vs. 4.46), stress (6.47 vs. 4.58), and anxiety (6.67 vs. 4.59). All patients reported clinically and statistically significant (p < .001) mean reductions in pain (−2.25 ± 1.87), stress (−2.50 ± 1.73), and anxiety (−2.52 ± 1.69), with patients in the HemOnc group reporting greater mean pain change (−2.54 vs. −1.87) than patients in the SCD group.ConclusionsThis study supports the clinical effectiveness of MT for addressing acute pain, stress, and anxiety among youth with hematologic and/or oncologic conditions. Future research is needed to identify optimal MT utilization.
Empirical study of factors that influence the perceived usefulness of online mental health community members
Authors: Li Jing , Liu Dexi , Wan Changxuan , Liang Zifang , Zhu Tingshao 
Published: February 2023

AbstractOnline mental health communities have become a major platform where individuals can talk about their mental health problems and obtain social support. This study aims to understand the antecedents of perceived usefulness among members in an online mental health community, while providing reference for the managers and users of online mental health communities. We obtained a total of 143,190 posts from ReachOut.com released by the CLPsych2017 shared task. Then, we used text mining to derive the independent and dependent variables. Next, a structural equation model observing the perceived usefulness of online mental health community members was constructed from the perspective of an information adoption model. The informativeness of help‐seeking posts had a significant positive relationship with the information quality of reply posts; the information quality of reply posts was a significant positive predictor of perceived usefulness, with the information quality of reply posts partially mediating the relationship between the informativeness of help‐seeking posts and perceived usefulness. The information provided by online mental health community members' help‐seeking posts and the quality of replies were found to be the factors that influenced perceived usefulness. This study highlights the importance of the information quality of reply posts and provides useful insights for administrators who can help users to improve their response quality and obtain the support they need.
Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study
Authors: Yasuda Kazuya , Takeda Ryuichiro , Ikeda Ryuji , Ishida Yasushi 
Published: February 2023

AbstractAimYokukansan is a Japanese herbal medicine used in psychiatry to treat behavioral and psychological symptoms of dementia and other psychiatric symptoms. However, the glycyrrhizic acid included in this medicine can cause pseudoaldosteronism and hypokalemia. We aimed to identify the risk factors for hypokalemia due to yokukansan.MethodsA retrospective cohort study was conducted on patients previously treated with yokukansan. The risk factors were determined by comparing the hypokalemia group with the non‐hypokalemia group for each parameter.ResultsThis study included 304 patients who received yokukansan treatment between April 2009 and March 2019. We found that 17.4% (n = 53) of the patients experienced yokukansan‐induced hypokalemia. Risk factors detected as significantly different between patients with and without yokukansan‐associated hypokalemia were low serum potassium concentration before yokukansan administration, dose 7.5 g /day or more, and dementia. Hypokalemia occurred earlier in patients with low albumin, low potassium, and dementia.ConclusionIt is necessary to pay attention to hypokalemia onset when administering yokukansan at 7.5 g or more to patients with low potassium levels and dementia. Our findings suggest that potassium levels must be checked early after yokukansan administration, especially in patients with low albumin, low potassium, and dementia.
HCN‐induced embryo arrest: passion fruit as an ecological trap for fruit flies
Authors: Yang Jing , Zheng Lixia , Liao Yonglin , Fu Yueguan , Zeng Dongqiang , Chen Wensheng , Wu Weijian 
Published: February 2023

AbstractBACKGROUNDFruit flies are important economic pests of fruits, vegetables, and nuts all over the world. In this study, a permanent ecological trap, which was created by the ovicidal effect of phytogenic hydrogen cyanide (HCN) liberated from passion fruits due to oviposition by fruit flies and can be used in the pest management, were determined.RESULTSObservation of fruit fly eggs in Passiflora within the passion fruit cultivation region in southern China, from Aug 2019 to Oct 2020 showed that the exotic Passiflora attracted the native fruit flies to oviposit, but the eggs could not hatch. Using classical staging to categorize embryonic development and fumigation assays, we show that oviposition by fruit fly on passion fruits, release HCN from the cyanogenic mesocarp. Exposure of the eggs to HCN causes arrest of embryonic development and finally the death of eggs.CONCLUSIONOur results reveal that the life cycle of fruit fly in Passiflora is interrupted at the egg stage. Consequently, we predict that this ecological trap may be permanent. Extensive cultivation of the Passiflora vine as a dead‐end trap crop may be an effective avenue to reduce populations of fruit fly pests. © 2023 Society of Chemical Industry.
Meso‐Hannokinol inhibits breast cancer bone metastasis via the ROS/JNK/ZEB1 axis
Authors: Zhu Yuan , Yin Wei‐feng , Yu Pei , Zhang Chao , Sun Ming‐hui , Kong Ling‐yi , Yang Lei 
Published: February 2023

AbstractDistal metastases from breast cancer, especially bone metastases, are extremely common in the late stages of the disease and are associated with a poor prognosis. EMT is a biomarker of the early process of bone metastasis, and MMP‐9 and MMP‐13 are important osteoclastic activators. Previously, we found that meso‐Hannokinol (HA) could significantly inhibit EMT and MMP‐9 and MMP‐13 expressions in breast cancer cells. On this basis, we further explored the role of HA in breast cancer bone metastasis. In vivo, we established a breast cancer bone metastasis model by intracardially injecting breast cancer cells. Intraperitoneal injections of HA significantly reduced breast cancer cell metastasis to the leg bone in mice and osteolytic lesions caused by breast cancer. In vitro, HA inhibited the migration and invasion of breast cancer cells and suppressed the expressions of EMT, MMP‐9, MMP‐13, and other osteoclastic activators. HA inhibited EMT and MMP‐9 by activating the ROS/JNK pathway as demonstrated by siJNK and SP600125 inhibition of JNK phosphorylation and NAC scavenging of ROS accumulation. Moreover, HA promoted bone formation and inhibited bone resorption in vitro. In conclusion, our findings suggest that HA may be an excellent candidate for treating breast cancer bone metastasis.
A Signal Amplification Strategy Using ATP as a Co‐Reaction Accelerator for the Electrochemiluminescence of Ru(bpy)32+/HEPES System and Detection of Iodide Anions**
Authors: Xu Tingting , Xu Panpan , Xu Guilin , Liu Mengyao , Zhu Yinggui 
Published: February 2023

AbstractAdenosine triphosphate is an important biological molecule that provides energy and substrate for various cellular biochemical processes,it's ubiquitous in our lives. In this work, a novel electrochemiluminescence (ECL) sensor composed of Ru(bpy)32+, 2‐[4‐(2‐hydroxyethyl)piperazin‐1‐yl] ethanesulfonic acid (HEPES) and adenosine 5’‐triphosphate disodium salt (ATP) was developed for the first time. In this ECL system, Ru(bpy)32+ was used as the luminophore, HEPES buffer was served as the co‐reactant, and ATP was added to the system to amplify the luminous signal to investigate the ECL behavior. Through fluorescence spectroscopy, ECL spectroscopy, and cyclic voltammetry (CV), it can be hypothesized that the possible ECL mechanism is that ATP acts as an advanced co‐reaction promoter to accelerate the oxidation of HEPES to HEPES+⋅, more HEPES⋅ can be generated, which then reacts with oxidized Ru(bpy)33+ to emit stronger ECL signals. Subsequently, the influence of the ATP concentrations and the CV scanning speed was investaged. Moreover, it was observed that I− could quench the ECL intensity, the linear relationship range of I− concentration is from 10−3 to 10−6 m, the limit of detection is 3.7×10−8 m (signal/noise=3), therefore, a new, highly sensitive, and selective ECL approach for I− detection was created.
Presence of a Molecular Ligand alters the Solvent Behavior of an Ionic Liquid: A Combined Physicochemical Properties, FTIR Spectroscopy and Dynamic Light Scattering Investigation
Authors: Rout Alok , Mishra Satyabrata , Ramanathan Nagarajan 
Published: February 2023

AbstractThe physicochemical properties of an ionic liquid (IL) based extraction system depends on the type of cation and anion present and the type of extractant dissolved in it. In this paper, we have investigated the solvent behavior of a ionic liquid based system comprising of a diglycolamide based extractant: T2EHDGA (N,N,N’,N’‐tetra(2‐ethylhexyl) diglycolamide) dissolved in an imidazolium based ionic liquid: [C4mim][NTf2] (1‐butyl‐3‐methylimidazolium bis(trifluoromethanesulfonyl) imide). The properties of IL systems such as dynamic viscosity (η) and density (ρ) were measured as a function concentration of T2EHDGA, nitric acid and the experimental temperature using a rolling ball viscosmeter and a U‐tube densitometer. Viscosity and density of IL phase increase and decrease respectively in the presence of ligand in it. Dynamic Light Scattering (DLS) results obtained by DLS spectrometer inferred the aggregation behavior of IL phase and the average aggregate size of IL increases in presence of T2EHDGA. The water uptake by IL phase upon acid equilibration inferred from FTIR spectroscopy specified a decrease in visocisty and density of the solvent. The evaluation of molecular volume (Vm) and standard entropy (So) offered higher values for T2EHDGA as compared to [C4mim][NTf2] whereas, the lattice potential energy (UPot) showed reverse trend. The refractive index (n) of T2EHDGA/IL mixture measured by a refractometer suggested the considerable changes in presence of T2EHDGA and nitric acid.