bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of Gas Production From Clayey Silt Hydrate Reservoirs Based on Near Wellbore Artificial Fractures Constructed Using High-Pressure Rotating Water Jets Technology
Authors: Li Zhanzhao , Wan Tinghui , Yu Yanjiang , Liang Qianyong , Lu Hongfeng , Wang Jingli , Tian Lieyu , He Huice , Li Keliang , Qiu Haijun 
Published: January 2023

Over 90% of the global hydrate resources are stored in very-low-permeability clayey silt reservoirs. The low permeability significantly restricts the efficiency of gas and water flow into the production well. To enhance gas production efficiency in low-permeability hydrate reservoirs, the high-pressure rotating water jets (HPRWJ) technology is proposed to construct near wellbore artificial fractures (NWAFs) in hydrate reservoirs. The HPRWJ avoid the risks of hydraulic fracturing as well as large-scale reservoir damage, which makes it more suitable for constructing fractures in hydrate-bearing sediments (HBS). In this article, the site SH7 in the South China Sea is studied to evaluate the feasibility of this technology for enhancing gas production of low-permeability hydrate reservoirs by numerical simulation. The results show that the gas productivity is increased by approximately three times by using the HPRWJ technology to construct NWAFs with a depth of 3 m. It is suggested that the proposed technology is a promising method for improving gas production from the low-permeability hydrate reservoirs. Furthermore, the gas production performance is closely related to NWAF depth, NWAF permeability, and NWAF spacing. For the site SH7 in the South China Sea, the NWAF depth, permeability, and spacing are recommended as 3 m, 3D, and 3 m, respectively.
Variation characteristics of stress distribution in the subchondral bone of the knee joint of judo athletes with long-term stress changes
Authors: Li Zhiqiang , Xu Guanghua , Wang Chengjun , Wang Qiuyuan , Liu Caiping , Guo Tingting , Wu Lijun , Cao Diankang 
Published: January 2023

ObjectiveTo investigate the distribution of bone density in the subchondral bone tissue of the knee joint due to the mechanical stress load generated by judo, the bone tissue volume of different densities and the bone remodeling characteristics of the subchondral bone of the knee joint.MethodsCT imaging data of the knee joint were collected from 15 healthy individuals as controls and 15 elite judo athletes. Firstly, they were processed by the CTOAM technique, and secondly, the distribution pattern of high-density areas of the knee joint was localized using nine anatomical regions. In addition, three tomographic images were selected in the sagittal, coronal, and axial 2D image windows to observe the distribution of different densities of bone tissue. Finally, the percentage of bone tissue volume (%BTV) and bone remodeling trend of bone tissues with different densities were determined.ResultsIn this study, high-density areas were found in the 4th, 5th, and 6th regions of the articular surface of the distal femur and the 1st, 2nd, 3rd, 4th, 5th, 6th, 7th and 8th regions of the tibial plateau in judo athletes; the distribution of high-density areas on the articular surface of the distal femur in control subjects was similar with judo athletes, and high-density areas were mainly found in the 4th and 5th regions of the tibial plateau. The %BTV of low (401-500HU in the distal femur; 301-400 HU and 401-500HU in the tibial plateau), moderate, and high bone density was higher in judo athletes than in controls in the subchondral bone of the distal femur and tibial plateau (P&lt; 0.05).ConclusionThe history of compressive stresses, struck stresses, soft tissue tension and pull, self-gravity and intra-articular stress loading generated by the lower limb exercise technique of judo leads to specific forms of stress distribution and bone tissue remodeling in the subchondral bone tissue within the distal femur and tibia plateau.
LncRNA MALAT1 mediates osteogenic differentiation in osteoporosis by regulating the miR-485-5p/WNT7B axis
Authors: Zhou Yuan , Xu Zhuo , Wang Yuanyi , Song Qiang , Yin Ruofeng 
Published: January 2023

IntroductionAccumulating evidence demonstrates that long non-coding RNAs (lncRNAs) are associated with the development of osteoporosis.MethodsThis study aimed to investigate the effects of MALAT1 on osteogenic differentiation and cell apoptosis in osteoporosis. MALAT1 level, detected by RT-qPCR, was downregulated in hindlimb unloading (HU) mice and simulated microgravity (MG)-treated MC3T3-E1 cells. Moreover, osteogenic differentiation-related factor (Bmp4, Col1a1, and Spp1) levels were measured by RT-qPCR and Western blot. ALP activity was detected, and ALP staining was performed. Cell apoptosis was assessed by flow cytometry.ResultsThe results revealed that MALAT1 upregulated the expression of Bmp4, Col1a1, and Spp1, and enhanced ALP activity. Knockdown of MALAT1 suppressed their expression and ALP activity, suggesting that MALAT1 promoted osteogenic differentiation. Additionally, MALAT1 inhibited apoptosis, increased Bax and caspase-3 levels, and decreased Bcl-2 level. However, knockdown of MALAT1 had opposite results. In MG cells, MALAT1 facilitated osteogenic differentiation and suppressed apoptosis. Furthermore, miR-485-5p was identified as a target of MALAT1, and WNT7B was verified as a target of miR-485-5p. Overexpression of miR-485-5p rescued the promotion of osteogenic differentiation and the inhibition of apoptosis induced by MALAT1. Knockdown of WNT7B abolished the facilitation of osteogenic differentiation and the suppression of apoptosis induced by downregulation of miR-485-5p.DiscussionIn conclusion, MALAT1 promoted osteogenic differentiation and inhibited cell apoptosis through the miR-485-5p/WNT7B axis, which suggested that MALAT1 is a potential target to alleviate osteoporosis.
Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China
Authors: Liu Wei , Song Liying , Sun Wei , Fang Weijin , Wang Chunjiang 
Published: January 2023

BackgroundTo investigate the distribution of microbes and drug susceptibility in patients with diabetic foot infections (DFI) and provide guidance for clinical empirical treatment and the rational selection of antibacterial drugs.MethodsRetrospective analysis of the pathogenic bacterium distribution and antimicrobial susceptibility isolated from 581 DFI patients with different Wagner grades.ResultsThe 534 positive samples included 473 cases (88.58%)) of monomicrobial infections and 61 cases (11.42%) of polymicrobial infections before antibiotic therapy. A total of 656 strains were cultivated, including 387 (58.99%) strains of gram-positive organisms (GPOs), 235 (35.82%) gram-negative bacilli (GNB), and 21 (3.20%) fungal strains. Polymicrobial infections mainly occurred in patients with Wagner grade 3-4 ulcers. GPOs were predominant in Wagner grades 1-3 (grade 1: 96.67%, grade 2: 76.52%, grade 3 62.81%), and the most common was Staphylococcus aureus (grade 1: 31.66%, grade 2: 33.04%, grade 3 35.53%). GNB were predominant in grades 4-5 (grade 4: 51.46%, grade 5:60%), and the most common GNB in Wagner grades 4-5 was Proteus (grade 4:27.88%, grade 5: 42.86%), while the most common GPO was Enterococcus (grade 4:34.48%, grade 5:25.00%). Staphylococcus (including MRSA) and Enterococcus were still highly sensitive to vancomycin, linezolid, and tigecycline. Most GNB were still highly sensitive to meropenem, tigecycline, ertapenem, and amikacin. Proteus was most sensitive to amikacin (97.14%), followed by meropenem (92%) and ertapenem (80%).ConclusionThe distribution of microbes and antimicrobial susceptibility in DFI patients varied with different Wagner grades. The most appropriate antimicrobial therapy should be selected based on the pathogen culture and antimicrobial susceptibility.
Modeling and analysis of factors affecting the integration of Beijing Tianjin Hebei low carbon economy based on SDM model
Authors: Zhu Lin , Wu Hua , Xu Ying 
Published: January 2023

Background: Under the guidance of carbon peak and carbon neutral targets, China’s economic development is facing unprecedented challenges. It is of great strategic significance and value to study the integrated development of regional low-carbon economy. The harmonious development of Beijing-Tianjin-Hebei (Beijing-Tianjin-Hebei) has become a national strategy, and its importance is prominent.Objective: To promote the regional economic integration of Beijing-Tianjin-Hebei is the top priority of promoting the development of Beijing-Tianjin-Hebei integration at present, and is the key to achieving the coordinated development and mutual benefit of Beijing-Tianjin-Hebei.Methods: In this context, this paper studies the fuzzy control evaluation algorithm of regional economy based on SDM model. Realized the prediction of the expansion of the low-carbon economy in Beijing-Tianjin-Hebei, and put forward the development strategy of the economic integration of Beijing-Tianjin-Hebei. The ranking of regional competitiveness of fuzzy control evaluation method is in line with the reality of today’s economic expansion. The application of fuzzy rules improves the speed, accuracy and objectivity of evaluation.Results: The final experiment shows that the accuracy of the algorithm is very high, reaching 95.14%. In addition, the algorithm has higher efficiency and better performance. The fuzzy control evaluation algorithm of regional economy can better predict the economic growth of Beijing, Tianjin and Hebei.Conclusion: Propose the development strategy of Beijing-Tianjin-Hebei low-carbon economic integration to further promote the development of Beijing-Tianjin-Hebei integration and promote the adjustment and optimization of China’s economic structure.
Experimental study of rock wool on the farmland soil erosion and crop growth of winter wheat and its comprehensive evaluation
Authors: Li Wei , Liu Shanshan , Wang Yicheng , Qin Tianling , Zhang Xin , Li Chenhao , Feng Jianming 
Published: January 2023

Introduction: Droughts and flooding occur frequently due to climate change and human activities, which have significantly affected the ecological environment of farmland and crop production. Rock wool (RW) has some properties like high porosity and water retention capacity, and it is widely used in green roofing and agricultural production to reduce flood and drought disaster.Methods: We set 24 artificial rainfall experiments to analyze the impact of RW on the farmland runoff, soil water storage capacity (SWSC), nitrogen and phosphorus loss and crop growth. Finally, the Critic-Entropy comprehensive evaluation method was used to select the best solution for RW embedding.Results: The result shows that RW could reduce the runoff by 49.6%–93.3%, and it made the SWSC increase by .2%–11% Vol in the 10–70 cm depth. During the runoff process, the concentration of nitrogen and phosphorus decreased with the increase of the RW volume, while the nitrogen and phosphorus loss reduced by 51.9%–96.6% and 72.4%–96.4% respectively when RW was buried in the farmland, so RW could effectively promote soil and water conservation. Finally, RW increased the plant biomass and yield by a maximum of 12.1% and 20.4% respectively due to the large retention of water and nutrients. Therefore, combined with the above experimental result, this study indicates that RW could obtain the best comprehensive benefit in the embedding volume of 536.73 m3/ha.Discussion: When the volume of RW embedding was too large, RW easily caused insufficient water storage in short-duration rainfall or irrigation, which made the RW unable to release water to alleviate the soil water deficit during the critical growth period, which may result in drought events being aggravated and crop yield reduced. Overall, this study is conducive to clarifying the comprehensive application effect of RW in agricultural production, pollution control, and urban landscape, and it provides an important basis for expanding its application field and promoting the stability of farmland ecosystems.
Host vs. pathogen evolutionary arms race: Effects of exposure history on individual response to a genetically diverse pathogen
Authors: Walsh Daniel P. , Felts Brandi L. , Cassirer E. Frances , Besser Thomas E. , Jenks Jonathan A. 
Published: January 2023

IntroductionThroughout their range, bighorn sheep (Ovis canadensis) populations have seen significant disease-associated declines. Unfortunately, understanding of the underlying epidemiological processes driving the disease dynamics in this species has hindered conservation efforts aimed at improving the health and long-term viability of these populations. Individual response to pathogen exposure emerges from dynamic interactions between competing evolutionary processes within the host and pathogen. The host’s adaptive immune system recognizes pathogens and mounts a defensive response. Pathogens have evolved strategies to overcome adaptive immune defenses including maintaining high genetic diversity through rapid evolution. The outcomes of this evolutionary warfare determine the success of pathogen invasion of the host and ultimately the success of conservation efforts.MethodsDuring an epizootic dominated by a single strain, we explore these host-pathogen dynamics by examining the variation in effects of pathogen invasion on captive bighorn sheep with differing histories of exposure to genetically diverse strains ofMycoplasma ovipneumoniae(Movi). We monitored clinical signs of disease and sampled animals and their environment to detect spread of Movi among 37 bighorn sheep separated into nine pens based on known exposure histories.ResultsWe documented Movi transmission within and across pens and we detected Movi DNA in air, water, and invertebrate samples. Higher levels of antibody to Movi prior to the epizootic were associated with a lower likelihood of presenting clinical signs of pneumonia. Nonetheless, higher antibody levels in symptomatic individuals were associated with more severe progressive disease, increased probability and speed of pneumonia-induced mortality, and reduced likelihood of returning to a healthy state. Bighorn sheep with previous exposure to a strain other than the predominant epizootic strain were more likely to recover.DiscussionOur results indicate that Movi-strain variability was sufficient to overwhelm the adaptive host immunological defenses. This outcome indicates, in free-ranging herds, past exposure is likely insufficient to protect bighorn sheep from infection by new Movi strains, although it influences the progression of disease and recovery within the herd. Therefore, given Movi-strain variability and the lack of immunological protection from past exposure, focusing management efforts on minimizing the introduction of Movi into bighorn herds, through separation of domestic and bighorn sheep and avoidance of management activities that create commingling of bighorn sheep carrying differing Movi strains, will likely be the most effective approach for reducing the effects of disease and achieving bighorn sheep conservation goals.
Primary sclerosing cholangitis and pancreatic cancer: A retrospective cohort study of United States veterans
Authors: Nguyen Anita , Torabi Sagvand Babak , Alizadeh Madeline , Nguyen Cydney , Scott William , von Rosenvinge Erik C. 
Published: January 2023

Primary sclerosing cholangitis (PSC) is associated with hepatobiliary and colorectal cancers, but it remains uncertain if PSC increases the risk for pancreatic cancer. While some European studies have suggested an increased risk of pancreatic cancer in PSC patients, other studies have not. And these studies did not well account for presence or absence of concomitant inflammatory bowel disease (IBD). The purpose of this study is to investigate the prevalence of pancreatic cancer in United States veterans with PSC both with and without IBD.MethodsThis retrospective study used International Classification of Diseases, Tenth Revision (ICD-10) codes to identify patients with PSC, IBD, and pancreatic cancer from the Veterans Affairs (VA) Corporate Data Warehouse. The prevalence of pancreatic cancer in patients with PSC only, IBD only, PSC with IBD, and neither PSC nor IBD were compared. Logistic regression was used to control for age, gender, chronic pancreatitis, diabetes mellitus, and tobacco and alcohol use.ResultsA total of 946 patients with PSC were identified from a population of over 9 million veterans. 486 (51.4%) of these had concurrent IBD. Additionally 112,653 patients with IBD without PSC were identified. When adjusted for confounding factors, patients with PSC had a significantly higher prevalence of pancreatic cancer compared to the general population and those with IBD without PSC (2.4% vs. 0.2% and 0.5%, respectively).ConclusionsVeterans with PSC, particularly those without concomitant IBD, have a high prevalence of pancreatic cancer compared to the general veteran population. Our findings support the need for multicenter prospective studies investigating the benefits of screening for pancreatic cancer in patients with PSC.
Efficacy and safety of neoadjuvant immunotherapy combined with chemoradiotherapy or chemotherapy in esophageal cancer: A systematic review and meta-analysis
Authors: Liu Yunsong , Bao Yongxing , Yang Xu , Sun Shuang , Yuan Meng , Ma Zeliang , Zhang Wanting , Zhai Yirui , Wang Yang , Men Yu , Qin Jianjun , Xue Liyan , Wang Jun , Hui Zhouguang 
Published: January 2023

BackgroundSignificant progress has been made in the investigation of neoadjuvant immune-chemoradiotherapy (NICRT) and neoadjuvant immune-chemotherapy (NICT) on the outcomes of esophageal cancer patients. To summarize the current developments, a systematic review and meta-analysis were conducted to evaluate the efficacy and safety of neoadjuvant immunotherapy combined with chemoradiotherapy or chemotherapy.MethodsA search strategy of prospective studies on esophageal cancer receiving neoadjuvant immunotherapy was predefined to scan PubMed, Embase, Cochrane, and additional major conferences for prospective studies. Efficacy was assessed by pathological complete response (pCR), major pathological response (MPR), and R0 resection rates. Safety was evaluated based on the incidence of grade ≥ 3 treatment-related adverse events (TRAEs), neoadjuvant therapy completion rate, surgical resection rate, and surgical delay rate. Differences between the NICRT and NICT groups were also analyzed.ResultsA total of 38 studies qualified for the analysis. The pooled pCR, MPR, and R0 resection rates were 30, 58, and 99%, respectively. The pCR and MPR in the NICRT vs. NICT group were 38% vs. 28% (p=0.078) and 67% vs. 57% (p=0.181), respectively. The pooled incidence of grade ≥ 3 TRAEs was 24% (NICRT,58%, I2 = 61% vs. NICT,18%, I2 = 79%; p&lt;0.001). In addition, the pooled neoadjuvant therapy completion and surgical resection rates were 92% and 85%, respectively; the difference was not statistically significant between the NICRT and NICT groups.ConclusionsNeoadjuvant immunotherapy combined with chemoradiotherapy or chemotherapy is effective and safe in the short term for locally advanced esophageal cancer. However, further randomized trials are needed to confirm which combined model is more favorable.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021284266, identifier CRD42021284266.
Impacts of river discharge, coastal geomorphology, and regional sea level rise on tidal dynamics in Pearl River Estuary
Authors: Li Xia , Cai Yanzi , Liu Zezheng , Mo Xiaobiao , Zhang Li , Zhang Cheng , Cui Baoshan , Ren Ze 
Published: January 2023

IntroductionRecently, accelerated sea-level rise (SLR) has raised major concerns on estuarine management and restoration because it modifies estuarine hydrodynamics, such as tidal inundation extent and amplitude, tidal current asymmetry, flood frequency, etc. Understanding underlying processes which regulate estuarine tidal dynamics is critical for mitigating potential impacts on the coastal population and development.MethodsWe selected the Pearl River Estuary (PRE), an estuary with a higher regional SLR compared to the global SLR as the study area. To identify the effects of regional SLR on tidal dynamics, we analyzed long-term records of four tidal variables from 19 gauge stations between 1952 and 2020, including annual highest tidal levels (AHTLs), annual lowest tidal levels (ALTLs), annual mean tidal ranges (AMTRs), and annual mean tidal levels (AMTLs).ResultsResults suggested that variability in tidal variables was site-specific. The AMTRs decreased gradually from offshore regions to the upper reaches of rivers with a maximum at the mouth of the estuary. In contrast, the magnitudes of the AHTLs, AMTLs, and ALTLs decreased when approaching the coastline. Distance to the coastline had the highest correlations with the AHTLs, ALTLs, and AMTLs, followed by river width and river depth. The local SLR was responsible for the temporal variability in AHTLs, ALTLs, and AMTLs at the estuarine mouth with correlation coefficients from 0.43 to 0.85 (P &lt; 0.001) but showed low correlations with these three tidal variables at the upper reaches of rivers (P &gt; 0.001). Instead, the tidal variables were highly correlated with river discharge at the upper reaches of rivers, especially for the AHTLs (correlation coefficient = 0.83, P &lt; 0.0001).ConclusionsOur study demonstrated that the tidal dynamics demonstrate significant spatial-temporal variability. Geomorphology, river discharge, and sea levels have jointly affected estuarine hydrodynamics.
Comparative analysis of four types of mesoscale eddies in the North Pacific Subtropical Countercurrent region - part II seasonal variation
Authors: Sun Wenjin , An Mengxuan , Liu Jishan , Liu Jie , Yang Jingsong , Tan Wei , Sian Kenny T. C. Lim Kam , Ji Jinlin , Liu Yu , Dong Changming 
Published: January 2023

The North Pacific Subtropical Countercurrent area (STCC) is high in mesoscale eddy activities. According to the rotation direction of the eddy flow field and the sign of temperature anomaly within the eddy, they can be divided into four categories: cyclonic cold-core eddy (CCE), anticyclonic warm-core eddy (AWE), cyclonic warm-core eddy (CWE) and anticyclonic cold-core eddy (ACE). CCE and AWE are called normal eddies, and CWE and ACE are named abnormal eddies. Based on the OFES data and vector geometry automatic detection method, we find that at the sea surface, the maximum monthly number of the CCE, AWE, CWE, and ACE occurs in December (765.70 ± 52.05), January (688.20 ± 82.53), August (373.40 ± 43.09) and August (533.00 ± 56.92), respectively. The number of normal eddies is more in winter and spring, and less in summer and autumn, while abnormal eddies have the opposite distribution. The maximum rotation velocity of the four types of eddies appears in June (11.71 ± 0.75 cm/s), June (12.24 ± 0.86 cm/s), May (10.63 ± 0.99 cm/s) and June (9.97 ± 0.91 cm/s), which is fast in winter and spring. The moving speed of the four types of eddies is almost similar (about 10 ~ 11 cm/s). The amplitude of normal and abnormal eddies is both high in summer and autumn, and low in winter and spring, with larger amplitudes in normal than abnormal eddies. The eccentricity (defined as the eccentricity of the ellipse obtained by fitting the eddy boundary) of the four types of eddies is also close to each other, and their variation ranges from 0.7 to 0.8, with no apparent seasonal variation. The vertical penetration depth, which has no significant seasonal difference, is 675.13 ± 67.50 m in cyclonic eddies (CCE and CWE), which is deeper than that 622.32 ± 81.85 m in anticyclonic eddies (ACE and AWE). In addition, increasing the defined temperature threshold for abnormal eddies can significantly reduce their numbers but does not change their seasonal variation trend.