bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-treatment functional connectivity of the cingulate cortex predicts anti-suicidal effects of serial ketamine infusions
Authors: Chen Xiaoyu , Zhang Bin , Yuan Shiqi , Luo Xin , Wang Mingqia , Hu Yiru , Zhou Yanling , Ning Yuping 
Published: March 2023

Abstract

Background
Although ketamine can rapidly decrease suicidal ideation (SI), its neurobiological mechanism of action remains unclear. Several areas of the cingulate cortex have been implicated in SI; therefore, we aimed to explore the neural correlates of the anti-suicidal effect of ketamine with cingulate cortex functional connectivity (FC) in depression.

Methods
Forty patients with unipolar or bipolar depression with SI underwent six infusions of ketamine over 2 weeks. Clinical symptoms and resting-state functional magnetic resonance imaging data were obtained at baseline and on day 13. Remitters were defined as those with complete remission of SI on day 13. Four pairs of cingulate cortex subregions were selected: the subgenual anterior cingulate cortex (sgACC), pregenual anterior cingulate cortex (pgACC), anterior mid-cingulate cortex (aMCC), and posterior mid-cingulate cortex (pMCC), and whole-brain FC for each seed region was calculated.

Results
Compared with non-remitters, remitters exhibited increased FC of the right pgACC–left middle occipital gyrus (MOG) and right aMCC–bilateral postcentral gyrus at baseline. A high area under the curve (0.91) indicated good accuracy of the combination of the above between-group differential FCs as a predictor of anti-suicidal effect. Moreover, the change of SI after ketamine infusion was positively correlated with altered right pgACC–left MOG FC in remitters (r = 0.66, p = 0.001).

Conclusions
Our findings suggest that the FC of some cingulate cortex subregions can predict the anti-suicidal effect of ketamine and that the anti-suicidal mechanism of action of ketamine may involve alteration of FC between the right pgACC and left MOG.
The Pleasures of Domesticity
Authors: Bier Laura 
Published: March 2023

AbstractThis article analyzes Egyptian print advertisements of gas stoves, refrigerators, and washing machines as a way to consider how the technopolitics of Egyptian modernity intersected with gender politics—both at the level of state policy and in everyday life—in the two decades following the 1952 revolution. It argues that the proliferation of advertisements for Egyptian-made stoves, refrigerators, and washing machines found in the popular press during this period envisioned domestic technology as a critical building block in a gendered social contract between the state and the Egyptian people. Aimed exclusively at women, such ads stressed values like pleasure, abundance, affordability, and leisure—a vision of society where every housewife could achieve her dreams and every family could have a modern kitchen. These idealized images were not a new feature of household advertisements. However, the language of pleasure, beauty, and happiness used to advertise household goods prior to the revolution became embedded in new gendered definitions of citizenship after it. Advertisements also depicted women as primary beneficiaries of Egyptian state socialism and, in doing so, papered over some of the tensions in the state’s plan to mobilize women as workers, housewives, and consumers.
Saving the Modern Woman
Authors: Mustonen Liina 
Published: March 2023

AbstractThis article looks at how specific gendered practices and ideas about female bodies were instrumentalized in the struggle for political authority during Egypt’s transitional period between 2011 and 2013. It argues that in the aftermath of the uprising, when Islamists won the parliamentary and presidential elections in Egypt, the figure of the “modern” woman gained renewed political significance. By exploring Egyptian English-language women’s lifestyle magazines, the article illustrates how socioeconomically privileged, Cairo-based women crafted “modern” female bodies and engaged in what Lila Abu-Lughod calls the “politics of modernity.” By delving into the world of Cairo’s wealthy and fashionable producers of lifestyle magazines, the article shows how specific bodily techniques and vocabularies of neoliberal feminism helped construct the idea of a “modern” woman. The “modern” female body then provided a location from which other bodies, considered traditional or not yet modern, could be judged. During Egypt’s transitional period, it was not the victimized Muslim woman who needed to be saved but the modern woman who felt that her lifestyle was under attack from Islamists. Based on an analysis of visual images and discourses, the article provides a contemporary example of the use of “modern” gendered subjecthood in creating hierarchies between women.
Productive Disengagement
Authors: Fard GG 
Published: March 2023

AbstractThis article examines whether academic representations of LGBTQ Iranians have increased over time and whether they have had harmful or beneficial ethical impacts. The article defines measures of “harm” and “benefit” by drawing on and adding to Canada’s Tri-Council Policy Statement on Ethical Conduct for Research Involving Humans. Such measures are then used to survey scholarship produced about LGBTQ Iranians. Results show that scholarly interest in “LGBTQ Iran” has increased from 2001 on. The article demonstrates the complexity of balancing ethical measures in research and argues that the benefits of representing marginalized groups may not always outweigh their related harms. Ultimately, a methodology of “productive disengagement” is advanced for researchers who seek to forego representation rather than pursue it.
Case Report: Identification of likely recurrent CEP290 mutation in a child with Joubert syndrome and cerebello-retinal-renal features.
Authors: Spahiu Lidvana , Sayer John A , Behluli Emir , Liehr Thomas , Temaj Gazmend 
Published: March 2023

Background. Joubert syndrome (JS) is a rare autosomal recessive ciliopathy with an estimated prevalence of 1 in 100,000. JS is characterized by hyperpnoea, hypotonia, ataxia, developmental delay and various neuropathological abnormalities in the brain including cerebellar hypoplasia and cerebellar vermis aplasia. JS can also have variable multi-organ involvement, including the retina, kidneys, liver, and musculoskeletal system. Methods and Results. Here we report a clinical description of two-year-old girl presenting with breathing difficulties, hyperechoic kidneys with loss of corticomedullary differentiation. Brain magnetic resonance imaging revealed the typical molar tooth sign consistent with a clinical diagnosis of JS and retinal examination showed severe retinal dystrophy leading to blindness. Molecular genetic analysis using whole exome sequencing and Sanger sequence confirmation demonstrated a homozygous mutation (c.5493delA, p.(A1832fs*19) in CEP290 which segregated from either parent and was consistent with the multisystem ciliopathy phenotype. This precise variant has been described previously in 2 families from the Kosovar-Albanian region suggesting this allele is a recurrent mutation in this population. Conclusions. Mutations in CEP290 lead to multisystem ciliopathy syndromes and molecular genetic diagnostics of such cases allows precise diagnosis, screening of at risk relatives and appropriate management.
Relationship between anal swab PCR for SARS-CoV-2 with gastrointestinal clinical manifestations and severity of COVID-19 infection in Indonesia
Authors: Muzellina Virly Nanda , Abdullah Murdani , Kurniawan Juferdy , Rizka Aulia 
Published: March 2023

Introduction: Coronavirus disease 2019 (COVID-19) cases caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Indonesia remain high. The virus can bind with ACE2 receptor which is not only found in the lungs, but also in the digestive tract. Thus, it allows SARS-CoV-2 infection in the gastrointestinal tract, gastrointestinal manifestations, and detection of viral RNA on anal swab using polymerase chain reaction (PCR). There hasn’t been similar study about the role of anal swab in Indonesia yet. Therefore, this study aims to determine the relationship between SARS-COV-2 anal swab PCR with gastrointestinal clinical manifestations, and the severity of COVID-19 in Indonesia. Methods: This is an analytical study with cross-sectional design. Samples were obtained from hospitalized COVID-19 patients from July 2020 to January 2021. Demographic data, clinical manifestations, severity, and SARS-CoV-2 anal swabs PCR were collected using case report form. Results: A total of136 patients were analyzed. 52 patients (38.2%) had positive SARS-CoV-2 anal swabs PCR and 84 patients (61.8%) had negative results. The most common gastrointestinal clinical manifestations were nausea and vomiting in 69 patients (50.7%), anorexia in 62 patients (45.6%), and abdominal pain in 31 patients (22.8%). There were 114 patients (83,8%) classified as mild-moderate symptoms and 22 patients (16,2%) classified as severe-critical symptoms. There was a statistically significant relationship between the gastrointestinal tract SARS-CoV-2 infection and gastrointestinal clinical manifestations (P=0.031). There was no statistically significant relationship between the gastrointestinal SARS-CoV-2 infection and the severity of COVID-19 infection (P = 0.844). Conclusions: This study showed there is a significant relationship between SARS-CoV-2 anal swab PCR with gastrointestinal clinical manifestations. There is no significant relationship between anal swab PCR with the severity of COVID-19 infection. Further studies should aim to assess the relationship using larger samples while also assessing the possibility of fecal-oral transmission.
A detailed methodology for the long-term in vitro culture and analysis of three-dimensional, self-structuring bone models generated from cell lines or primary osteoblastic cell populations
Authors: Finlay Melissa , Hill Laurence A , Neag Georgiana , Patel Binal , Chipara Miruna , Lamont Hannah C , Frost Kathryn , Patrick Kieran , Lewis Jonathan W , Nicholson Thomas , Edwards James , Jones Simon W , Grover Liam M , Naylor Amy J 
Published: March 2023

Background: There are insufficient in vitro bone models that accommodate long-term culture of osteoblasts and support their differentiation to osteocytes. The increased demand for effective therapies for bone diseases, and the ethical requirement to replace animals in research, warrants the development of such models. Here we present an in-depth protocol to prepare, create and maintain three-dimensional, in vitro, self-structuring bone models that support osteocytogenesis and long-term osteoblast survival (>1 year). Methods: Osteoblastic cells are seeded on a fibrin hydrogel, cast between two beta-tricalcium phosphate anchors. Analytical methods optimised for these self-structuring bone model (SSBM) constructs, including qPCR, immunofluorescence staining and XRF, are described in detail. Results: Over time, the cells restructure and replace the initial matrix with a collagen-rich, mineralising one; and demonstrate differentiation towards osteocytes within 12 weeks of culture. Conclusions: Whilst optimised using a secondary human cell line (hFOB 1.19), this protocol readily accommodates osteoblasts from other species (rat and mouse) and origins (primary and secondary). This simple, straightforward method creates reproducible in vitro bone models that are responsive to exogenous stimuli, offering a versatile platform for conducting preclinical translatable research studies.
Using Decision Analysis to Determine the Feasibility of a Conservation Translocation
Authors: Keating Laura M. , Randall Lea , Stanton Rebecca , McCormack Casey , Lucid Michael , Seaborn Travis , Converse Sarah J. , Canessa Stefano , Moehrenschlager Axel 
Published: March 2023

Conservation translocations, intentional movements of species to protect against extinction, have become widespread in recent decades and are projected to increase further as biodiversity loss continues worldwide. The literature abounds with analyses to inform translocations and assess whether they are successful, but the fundamental question of whether they should be initiated at all is rarely addressed formally. We used decision analysis to assess northern leopard frog reintroduction in northern Idaho, with success defined as a population that persists for at least 50 years. The Idaho Department of Fish and Game was the decision maker (i.e., the agency that will use this assessment to inform their decisions). Stakeholders from government, indigenous groups, academia, land management agencies, and conservation organizations also participated. We built an age-structured population model to predict how management alternatives would affect probability of success. In the model, we explicitly represented epistemic uncertainty around a success criterion (probability of persistence) characterized by aleatory uncertainty. For the leading alternative, the mean probability of persistence was 40%. The distribution of the modelling results was bimodal, with most parameter combinations resulting in either very low (<5%) or relatively high (>95%) probabilities of success. Along with other considerations, including cost, the Idaho Department of Fish and Game will use this assessment to inform a decision regarding reintroduction of northern leopard frogs. Conservation translocations may benefit greatly from more widespread use of decision analysis to counter the complexity and uncertainty inherent in these decisions. History: This paper has been accepted for the Decision Analysis Special Issue on Decision Analysis to Advance Environmental Sustainability. Funding: This work was supported by the Wilder Institute/Calgary Zoo, the U.S. Fish and Wildlife Service [Grant F18AS00095], the NSF Idaho EPSCoR Program and the National Science Foundation [Grant OIA-1757324], and the Hunt Family Foundation. Supplemental Material: The online appendix is available at https://doi.org/10.1287/deca.2023.0472 .
Validity and intrarater reliability of a novel device for assessing Plantar flexor strength
Authors: O’Neill Seth , Weeks Alice , Nørgaard Jens Eg , Jorgensen Martin Gronbech 
Published: March 2023

IntroductionPlantar flexor weakness is an identified prospective factor for developing Achilles tendinopathy. Various authors have reported relationships between symptoms and weakness of this muscle group. Despite this relationship, many clinicians and researchers fail to examine Plantar flexor strength due to the cumbersome, stationary and expensive nature of an isokinetic dynamometer (IKD), known as the “Gold Standard”. This study examined the validity and reliability of a fast, easy and portable device for assessing plantarflexion.MethodsValidity between the Cybex NORM® by Humac and the C-Station by Fysiometer was explored using Pearson correlation coefficient. Participants were randomly selected to start in the Cybex NORM® or the FysioMeter C-Station. Intra-rater reliability on the C-station was investigated by test-retest two days apart using Intraclass Correlation Coefficient (ICC). All testing involved isometric maximal force of the soleus muscle with the knee at 90 degrees flexion.Results40 healthy university students were recruited for the validity part, while 65 healthy university students were recruited for the reliability part of the study. The mean peak torque on the IKD was 198.55Nm (SD 94.45) versus 1443.88 (412.82)N on the C-Station. The results of the Pearson correlation revealed an r-value of r = 0.72 with a 95%CI 0.52–0.84. The test re-test reliability was calculated as an ICC of 0.91 with a (95%CI 0.86–0.94).ConclusionsThe C-Station by Fysiometer appears to provide valid measures and have excellent reliability for Plantar flexor isometric strength. It would appear suitable for both clinical and research work.
Epidemiology and demographics of slipped capital femoral epiphysis in South Korea: A nationwide cohort study
Authors: Kim Nak Tscheol , Min Jae Jung , Ji Eunjeong , Park Moon Seok , Sung Ki Hyuk 
Published: March 2023

Background
This study investigated the epidemiology and demographics of slipped capital femoral epiphysis (SCFE) in South Korea using a nationwide population-based database.

Methods
Information on sex, age at onset, endocrine comorbidities, history of growth hormone therapy, history of radiation therapy, surgical methods, and complications in patients with SCFE aged younger than 18 years between 2007 and 2019 was retrieved from the Korean Health Insurance Review and Assessment Service database.

Results
Data were available for 586 children (429 boys, 157 girls). The average age at onset was 11.1 ± 1.8 years (boys, 11.3 ± 1.9; girls, 10.6 ± 1.5). Five hundred and twenty-nine (90.3%) patients were aged 9–14 years; the incidence rate in this age group was 6.0/100,000 (95% confidence interval, 5.5–6.6) and significantly higher in boys (8.4 vs 3.5, p<0.001). There was a significant increase in the annual incidence rate from 0.96/100,000 in 2009 to 2.05/100,000 in 2019 (p = 0.006). Ninety-five patients (16.2%) had endocrine comorbidities or a history of hormone/radiation therapy. Osteotomy and internal fixation were performed in 59 patients and in situ pinning in 527. Seventy-six patients developed postoperative complications.

Conclusion
The annual incidence rate of SCFE in South Korea has increased since 2009.
SARS-CoV-2 transmission among health care workers, an outbreak investigation using whole-genome sequencing
Authors: te Paske K. S. , Tienen C. van , Dunk D , Pelt D. van , Smit P. W. 
Published: March 2023

Background
We report an outbreak investigation to map intra-hospital transmission among health care workers (HCW) using epidemiological and whole-genome sequencing data.

Methods
Fourteen clinical wards (COVID-19 and non-COVID-19) with high infection rates of SARS-CoV-2 among HCW were selected and demographical, epidemiological and sequencing data were collected of all HCW testing positive by RT-PCR. Clustered cases were identified based on first disease onsets and differences in single nucleotide polymorphisms (SNP’s) and were analysed for additional characteristics.

Results
Data was collected for 123 HCW. Out of 123 HCW, 65 (53%) worked at eight non-COVID-19 wards, 56 (46%) at four COVID-19 wards, one (<1%) worked on several wards and for one (<1%) it was unknown. One major cluster (n = 34) and three minor clusters (n = 2,3,4; total n = 9) comprising of 43 HCW (35%) were found after comparing our study population (n = 123) with the circulating regional sequences (n = 819). In clustered cases work was most often the suspected source of infection and continuing work while having symptoms occurred in all clusters, ranging from 1–6 days.

Conclusion
Our findings strongly indicate transmission of SARS-CoV-2 among HCW. Whole-genome sequencing is useful for identification of clusters and can give direction to targeted infection prevention measures.
Preterm birth and maternal heart disease: A machine learning analysis using the Korean national health insurance database
Authors: Lee Jue Seong , Choi Eun-Saem , Hwang Yujin , Lee Kwang-Sig , Ahn Ki Hoon 
Published: March 2023

Background
Maternal heart disease is suspected to affect preterm birth (PTB); however, validated studies on the association between maternal heart disease and PTB are still limited. This study aimed to build a prediction model for PTB using machine learning analysis and nationwide population data, and to investigate the association between various maternal heart diseases and PTB.

Methods
A population-based, retrospective cohort study was conducted using data obtained from the Korea National Health Insurance claims database, that included 174,926 primiparous women aged 25–40 years who delivered in 2017. The random forest variable importance was used to identify the major determinants of PTB and test its associations with maternal heart diseases, i.e., arrhythmia, ischemic heart disease (IHD), cardiomyopathy, congestive heart failure, and congenital heart disease first diagnosed before or during pregnancy.

Results
Among the study population, 12,701 women had PTB, and 12,234 women had at least one heart disease. The areas under the receiver-operating-characteristic curves of the random forest with oversampling data were within 88.53 to 95.31. The accuracy range was 89.59 to 95.22. The most critical variables for PTB were socioeconomic status and age. The random forest variable importance indicated the strong associations of PTB with arrhythmia and IHD among the maternal heart diseases. Within the arrhythmia group, atrial fibrillation/flutter was the most significant risk factor for PTB based on the Shapley additive explanation value.

Conclusions
Careful evaluation and management of maternal heart disease during pregnancy would help reduce PTB. Machine learning is an effective prediction model for PTB and the major predictors of PTB included maternal heart disease such as arrhythmia and IHD.
An Unusual Case of Ascites
Authors: Nah Chung Yau , Fueng-Hin Liang Raymond 
Published: March 2023

ABSTRACT
Cirrhotic portal hypertension is the most common cause of new-onset ascites. The clinician, however, should be cognizant of rarer causes of ascites, especially when clinical and laboratory parameters are not in keeping with cirrhosis. We present a case of urinoma as the cause of an initial presentation of ascites.
Universal Health Coverage di Bali: Konsep, Implementasi, dan Tantangan
Authors: Anggapurana Pidada Ida Bagus 
Published: March 2023

Universal Health Coverage(UHC) muncul bertujuan untuk memberikan sebuah jaminan pelayanan kesehatan secara berkualitas kepada setiap individu tanpa terkecuali. Indonesia merupakan salah satu negara yang telah mendorong terselenggaranya konsep UHC melalui berbagai pendekatan. Seperti mengeluarkan regulasi, mendorong reformasi-birokrasi, hingga skema-skema teknis di dalamnya. Idealitas di atas kertas ternyata masih memenuhi beberapa kendala di lapangan yang menyebabkan tidak sedikit pemerintah daerah ikut membuat sebuah program jaminan berbasis lokalitas. Salah satu daerah yang telah melakukan inisiatif dalam mewujudkan jaminan kesehatan universal adalah Kabupaten Badung dengan program Krama Badung Sehat (KBS). Sehingga penelitian ini memunculkan pertanyaan bagaiamana konsep dan implementasi dari jaminan kesehatan daerah yang dikeluarkan oleh Pemerintah Kabupaten Badung dengan nama program Krama Badung Sehat(KBS). Kemudian tantangan seperti apa yang dihadapi oleh Pemerintah Daerah Kabupaten Badung dalam pengimplementasian program tersebut. Metode penelitian ini menggunakan Penelitian ini menggunakan pendekatan kualitatif dan dianalisis secara deskriptif. Jenis data yang digunakan dalam penelitian ini adalah data primer dan data sekunder. Selanjutnya teknik pengumpulan data menggunakan wawancara, observasi, dan studi dokumentasi. Hasil penelitian ini menunjukan bahwa Pemerintah Daerah Kabupaten Badung menciptakan program Krama Badung Sehat (KBS) sebagai upaya dalam menjamin pelayanan kesehatan bagi masyarakat Badung. Pada implementasinya, program KBS memiliki banyak manfaat tambahan dibandingkan program JKN-KIS secara spesifik ada lebih dari 15 manfaat yang tidak tercover oleh JKN. Meskipun telah dirancang sedemikian rupa akan tetapi program KBS masih memiliki tantangan antara lain pertama adalah kurang masifnya sosialisasi. Kedua adalah diperlukannya sebuah perencanaan yang strategis. Ketiga Keterbatasan finansial.
Kata Kunci : Kramas Badung Sehat, Universal Health Coverage(UHC), Program Kesehatan JKN,