bluuebunny/crossref_metadata_2025_split huggingface dataset:
Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2
Authors: Cheng Fang-Ju , Ho Chien-Yi , Li Tzong-Shiun , Chen Yeh , Yeh Yi-Lun , Wei Ya-Ling , Huynh Thanh Kieu , Chen Bo-Rong , Ko Hung-Yu , Hsueh Chen-Si , Tan Ming , Wu Yang-Chang , Huang Hui-Chi , Tang Chih-Hsin , Chen Chia-Hung , Tu Chih-Yen , Huang Wei-Chien 
Published: June 2023

Abstract
Background
Artemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since ancient China due to its anti-microbial infection, anti-allergy, and anti-inflammation activities. Therefore, the potential of A. argyi and its constituents in reducing the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was investigated in this study.

Results
Among the phytochemicals in A. argyi, eriodictyol and umbelliferone were identified to target transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) proteins, the essential factors for the cellular entry of SARS-CoV-2, in both FRET-based enzymatic assays and molecular docking analyses. These two ingredients of A. argyi suppressed the infection of ACE2-expressed HEK-293 T cells with lentiviral-based pseudo-particles (Vpp) expressing wild-type and variants of SARS-CoV-2 spike (S) protein (SARS-CoV-2 S-Vpp) via interrupting the interaction between S protein and cellular receptor ACE2 and reducing the expressions of ACE2 and TMPRSS2. Oral administration with umbelliferone efficiently prevented the SARS-CoV-2 S-Vpp-induced inflammation in the lung tissues of BALB/c mice.

Conclusions
Eriodictyol and umbelliferone, the phytochemicals of Artemisia argyi, potentially suppress the cellular entry of SARS-CoV-2 by preventing the protein binding activity of the S protein to ACE2.
Modified rank sum nonparametric CFAR to combat clutter edge
Authors: Xiangwei Meng , Yuan Meng 
Published: June 2023

AbstractThe classical rank sum (RS) nonparametric constant false alarm rate (CFAR) detector plays an important role in the theoretical study and practical application of radar target detection. In order to improve the ability of the classical RS nonparametric detector to control the false alarm rate at clutter edges, a modified rank sum (MRS) nonparametric CFAR based on the mean ratio of the samples in the leading and lagging windows is proposed. The analytical expressions of the detection probability and false alarm rate of the MRS nonparametric CFAR in homogeneous background and at clutter edges are derived, and a comparison to the performance of the classical RS nonparametric detector along with some conventional parametric CFAR schemes in homogeneous background, multiple targets situation and clutter edges is made. The numerical results show that the detection performance of the MRS nonparametric CFAR in homogeneous background and in a moderate number of interfering targets situation is close to that of the classical RS nonparametric detector, and its ability to control the rise of the false alarm rate at clutter edges is evidently improved.
Asymptomatic hepatic pseudoaneurysm identified 25 days after knife injury: a case report
Authors: Sugi Tomoyuki , Maruyama Tsunehiko , Nozaki Reiji , Kawahara Masato , Kamoshida Megumi , Narita Sakura , Takaku Hideya , Azuma Kazuaki , Chiba Yoshiro , Oda Tatsuya 
Published: June 2023

Abstract
Background
Hepatic pseudoaneurysm (HPA) is a rare complication that can occur after liver trauma and carries a high risk of rupture. HPA is usually asymptomatic until rupture, so performing routine surveillance of liver trauma patients is important. Most posttraumatic HPA occurs within the first week after injury, so surveillance imaging ~ 7 days postinjury is suggested.

Case presentation
We herein report a 47-year-old man who was diagnosed with asymptomatic HPA 25 days after a knife injury. The patient was transferred to the emergency room after attempting suicide by stabbing himself in his abdomen with a knife. The knife was surgically removed, and the postoperative course was uneventful. Computed tomography (CT) on postoperative day (POD) 12 showed no HPA. However, follow-up CT on POD 25 revealed HPA. The HPA was treated with coil embolization. The patient was discharged with no complications. One year after the injury, the patient had no recurrence or medical problems.

Conclusion
When managing patients with penetrating liver trauma, it is important to note that HPA may not be identifiable on CT early after injury but may still develop later.
Cancer morbidity and mortality trends in Trinidad and Tobago (2008–2018)
Authors: Gopaul Chavin D. , Singh Aruna , Williams Akil , Ventour Dale , Thomas Davlin 
Published: June 2023

Abstract
Purpose
Cancer is a leading cause of death in the Caribbean, and the Republic of Trinidad and Tobago is no exception. Evidence suggests that cancer incidence and mortality may vary based on demographic factors across the different cancer types. This study aimed to investigate the incidence and mortality trends associated with cancer cases in Trinidad and Tobago for the period 2008–2018, across different age groups, gender, and ethnicity.

Methods
Data on 15,029 incident cancer cases were reported to the Dr. Elizabeth Quamina Cancer Registry between 2008 and 2018. The retrospective data were analyzed by sex, ancestry, and age, and were reported using Trinidad and Tobago population statistics for the period 2008–2018.

Results
The incidence of prostate and breast cancers was high among males and females, respectively. Among males, the highest cancer mortality was associated with prostate, lung, colon, blood, and pancreatic cancers, respectively. Among females, the highest cancer mortality was associated with breast, ovary, colon, blood, and pancreatic cancers. The frequency of occurrence of the top five cancer sites was the highest among Afro-Trinidadians followed by Indo-Trinidadians. Most females diagnosed with breast cancer were at a localized stage, while most males diagnosed with breast cancer were at a distant or regional stage. Most individuals diagnosed with blood cancer were at a distant stage. For lung and colon cancer, the stage of diagnosis for most males and females was either distant or unknown. Majority of males are diagnosed with prostate cancer at an unknown stage.

Conclusions
The findings indicate highest cancer incidence and mortality occur among Afro-Trinidadians. The stage at diagnosis varies across cancer types and gender.
Volume of the proximal half of the thoracic aorta is the most comprehensive FDG-PET/CT indicator of arterial aging throughout adulthood
Authors: Hurstel Moira , Joly Laure , Imbert Laetitia , Zimmermann Gaetan , Roch Véronique , Schoepfer Pauline , Lamiral Zohra , Salvi Paolo , Benetos Athanase , Verger Antoine , Marie Pierre-Yves 
Published: June 2023

Abstract
Introduction
18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and computed tomography (CT) features of the proximal and more elastic half of the thoracic aorta are known to correlate with aorta stiffness in older populations. This prospective study aimed to analyze the changes in these FDG-PET/CT features between young, middle-aged, and older adults, and investigate associations with arterial stiffness and blood pressure (BP).

Methods
Young (< 40 years), middle-aged (40-to-60 years), and older (> 60 years) adults, who underwent an FDG-PET/CT, were prospectively recruited. FDG-PET/CT features of the proximal half of the thoracic aorta were analyzed relative to the age categories, BP and carotid-femoral pulse wave velocity (PWV), a reference indicator of aorta stiffness.

Results
We included 79 patients (38 women; 22 young, 19 middle-aged, and 38 older adults). An increase in age category was associated with increases in mean standardized uptake values (SUVs) of blood and aorta and most significantly in aorta SUV heterogeneity, represented by SUV standard deviation (SUV-SD), aorta calcification volume, and the aorta volume indexed to body surface area. However, this indexed aorta volume was the sole variable: (i) exhibiting a stepwise increase from young (median: 25 cm3/m2 [interquartile range: 20–28 cm3/m2]), to middle-aged (41 [30–48] cm3/m2, p < 0.001 vs. Young), and older (62 [44–70] cm3/m2, p < 0.001 vs. middle-age) adults, and (ii) selected in the multivariate predictions of systolic, diastolic, and pulse BP. Indexed aorta volume was also a multivariate predictor of PWV but in association with SUV-SD and hypertension.

Conclusion
In a population of patients referred to an FDG-PET/CT investigation, the indexed volume of the proximal and more elastic half of the thoracic aorta is the most comprehensive indicator of arterial aging. This imaging parameter exhibits a stepwise increase from young to middle-aged and older adults, is strongly linked to inter-individual changes in both arterial stiffness and BP, and thus, could help assess the early phases of arterial aging.
Trial registration ClinicalTrial.gov, NCT03345290. Registered 17 November 2017, https://clinicaltrials.gov/ct2/show/NCT03345290?term=NCT03345290&draw=2&rank=1
The predictive role of personality traits and demographic features on post-traumatic stress disorder in a sample of COVID-19 hospitalized patients
Authors: Mousavi Nazanin , Effatpanah Mohammad , Molaei Aghil , Alesaeidi Samira 
Published: June 2023

Abstract
Background
Hospitalized COVID-19 patients suffer from psychological and psychiatric disorders such as post-traumatic stress disorder, depression, and anxiety. Because there was no comprehensive study on psychological factors in hospitalized COVID-19 patients in Iran, we investigated the predictive role of personality traits and demographic features on post-traumatic stress disorder in COVID-19 hospitalized patients.

Results
In this research method first, 160 patients selected randomly and completed relevant questionnaires, which are prepared online. We examined the multivariate linear regression between the mentioned variables. The results showed that the independent variables are able to predict changes in post-traumatic stress disorder (P < 0.001). The percentage of explanation of changes in dependent variables was equal to 0.77, 0.65, 0.71, and 0.68, respectively.

Conclusion
People’s personality traits play a key role in facing and responding to stressful environmental events for instance COVID-19 pandemic, and as a result, some personality traits such as conscientiousness protect people from stress even though, neuroticism personality trait cause instability and make people more stresses, identifying these traits and treating them is.
Towards an objective measurement of sleep quality in non-human animals: using the horse as a model species for the creation of sleep quality indices
Authors: Greening Linda , Allen Sian , McBride Sebastian 
Published: June 2023

ABSTRACT
Sleep disturbance is observed across species, resulting in neurocognitive dysfunction, poor impulse control and poor regulation of negative emotion. Understanding animal sleep disturbance is thus important to understand how environmental factors influence animal sleep and day-to-day welfare. Self-reporting tools for sleep disturbance commonly used in human research to determine sleep quality cannot be transferred to non-verbal animal species research. Human research has, however, successfully used frequency of awakenings to create an objective measurement of sleep quality. The aim of this study was to use a novel sleep-quality scoring system for a non-human mammalian species. Five separate sleep quality indices calculations were developed, using frequency of awakenings, total sleep time and total time spent in different sleep states. These indices were applied to a pre-existing data set of equine sleep behaviour taken from a study investigating the effects of environmental change (lighting and bedding) on the duration of time in different sleep states. Significant treatment effects for index scores both differed and aligned with the original sleep quantity results, thus sleep quality may be a useful alternative measurement of sleep disturbance that could be used to investigate impactful (emotional, cognitive) effects on the animal.
Attitudes toward and knowledge of collaboration of dental and medical practice among medical students in Southern India: a cross-sectional questionnaire survey
Authors: Atul Kumar Harshit , Uppoor Ashita , Kadakampally David , Unnikrishnan B , Mithra Prasanna 
Published: June 2023

Background: Enhancing oral health care services provided through inter-professional collaboration between medical and dental practitioner is important, and even essential. The purpose of this study is to assess the attitude toward and knowledge of medical-dental collaborative practice among medical students attending colleges in Southern India. Methods: A cross sectional questionnaire survey was conducted by inviting 900 medical students and interns of medical colleges in coastal South India with prior information and permission. The questionnaire consisted of 11 questions to assess attitude toward and knowledge of medical-dental collaborative practice and was distributed in pen & paper format to participants who agreed to take part in the study. Chi square test was employed for data analysis. The responses obtained were correlated with age, gender and year of study of participants using Pearson’s correlation test Results: Most of the students agreed that oral health was an integral part of systemic health, however participants disagreed on attending compulsory rotation in dentistry at a statistically significant level (p<0.05), moreover participants did not agree with physicians having an active role in motivating their patients for regular dental check-up. 82% of the medical students believe that dental check-up should be included in health packages under health insurance. A statistically significant (p<0.05) difference was observed among 3 rd year & 4 th year students and interns and also it was found that female students provided more positive responses towards medical-dental collaboration. Conclusions: Even though medical students showed fairly positive attitudes and knowledge towards dentistry, the analysis within the study groups showed that knowledge and attitudes regarding the collaborative practice worsened over the academic years among the medical students.
Attitude towards dengue control efforts with the potential of digital technology during COVID-19: partial least squares-structural equation modeling
Authors: Purnama Sang Gede , Susanna Dewi , Achmadi Umar Fahmi , Eryando Tris 
Published: June 2023

Background: Dengue fever is still a public health issue in Indonesia, and during the coronavirus disease 2019 (COVID-19) pandemic, integrated digital technology will be required for its control. This study aims to identify critical indicators influencing attitudes towards dengue control related to the potential for implementing digital technology. Methods: This was a cross-sectional survey, with 515 people willing to fill out an online questionnaire. The analysis was conducted using Partial Least Square-Structural Equation Modelling (PLS-SEM). There were 46 indicators used to assess attitudes toward dengue control, which were organized into six variables: the need for digital information systems, perceptions of being threatened with dengue, the benefits of dengue control programs, program constraints, environmental factors and attitudes in dengue control. Results: The source of information needed for dengue control was mainly through social media. There was a positive relationship between perception of environmental factors to perception of dengue threat, perception of program constraints, perception of program benefits, and perception of digital technology needs. Perception of program benefits and threatened perception of dengue have a positive relationship with perception of digital technology needs. Conclusions: This model showed the variables perception of digital technology and perception of benefits had a positive association with attitude towards dengue control
Evaluating the clinical outcomes of thulium fiber laser (TFL) in comparison to holmium laser in the treatment of urinary tract stones – A systematic review
Authors: Tritanto Rio , Deswanto Isaac 
Published: June 2023

Holmium:Yttrium-Aluminum-Garnet (Ho:YAG) had been considered the gold standard for treating urinary tract stones. However, advancements in laser technology have introduced thulium fiber laser (TFL) as a potential alternative. Preliminary studies have indicated that TFL may have certain advantages over Ho:YAG laser in lithotripsy. This systematic review compared the clinical outcomes of TFL and Ho:YAG laser for urinary tract stone treatment, focusing on operating time, stone-free rate (SFR), retropulsion, and complications. A systematic search was conducted on PubMed and ScienceDirect for original articles published within the last 5 years, comparing the clinical outcomes of Ho:YAG and TFL in lithotripsy. Inclusion criteria were English-language studies focusing on Ho:YAG and TFL laser energy for urinary tract stones, with accessible full-text articles comparing clinical outcomes. Excluded were studies discussing lasers for conditions other than urinary tract stones or using lasers other than TFL and Ho:YAG. Four studies (544 procedures) met the criteria and underwent risk of bias assessment using Risk of Bias 2 (ROB-2) for randomized trials and Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) for cohort studies. The data were presented in tables and charts. In this review, TFL demonstrated a shorter operating time compared to Ho:YAG (and higher stone-free rates in two studies. TFL also had a lower incidence of stone retropulsion. Intra-operative complication rates varied between the groups for ureterorenoscopy (URS) and retrograde intrarenal surgery (RIRS) procedures, while TFL had a higher rate of prolonged haematuria during mini percutaneous nephrolithotomy (PCNL) procedures. Postoperative complications were similar in both groups. Limitations of this review include procedural and laser setting heterogeneity, a small number of studies, and the lack of registration and protocols. In conclusion, TFL is an effective and safe alternative to Ho:YAG laser for lithotripsy, offering shorter operation time, higher stone-free rates, and reduced stone retropulsion.
PKD1 gene mutation and ultrasonographic characterization in cats with renal cysts
Authors: Jaturanratsamee Kotchapol , Jiwaganont Palin , Sukumolanan Pratch , Petchdee Soontaree 
Published: June 2023

Background: Polycystic kidney disease (PKD) has a complex phenotype partly explained by genetic variants related to this disease. Ultrasonography is a promising approach for defining clinical signs. This study aimed to assess kidney characteristics in cats with Polycystin-1 (PKD1) gene mutations and wild-type cats. Kidney characteristics were identified by ultrasonography. Methods: A total of 108 cats of variable breeds aged an average of 37.01±3.50 months were included. Blood examination and biochemical tests were evaluated. For cystic formation, renal ultrasound was performed. The PKD1 gene mutation was identified via polymerase chain reaction (PCR) and DNA sequencing. Matrix correlation and effectiveness of ultrasound for PKD1 mutation detection were determined. Results: The results showed that 19.44% of cats had PKD1 mutations, a high prevalence in Persian and Persian-related breed cats. Our results demonstrated the characteristics of kidneys in wild-type cats and cats with gene mutations. Based on ultrasonography results, there was an association between cats with gene mutations and cyst formation. The findings indicated that ultrasound did not detect cysts in cats aged 4-36 months, supporting the evidence that PKD1 gene mutations may not be present. This study found high sensitivity and renal specificity ultrasound for PKD1 heterozygous mutation. Moreover, cystic formation via renal ultrasound showed an increased risk for PKD1 mutation 2,623 times compared to normal kidneys. Conclusions: Ultrasonographic examination, coupled with genetic investigations, may help to clarify the phenotypic variability of PKD1. The phenotypic profile of PKD1 will guide therapeutic outcomes and reduce the prevalence of PKD morbidity and mortality in cats.
The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study
Authors: Koritala Bala S. C. , Dakup Panshak P. , Porter Kenneth I. , Gaddameedhi Shobhan 
Published: June 2023

Background: The natural day-night cycle synchronizes our circadian rhythms, but modern work practices like night shifts disrupt this pattern, leading to increased exposure to nighttime light. This exposure is linked to various health issues. While some studies have explored the effects of night shifts on human circadian rhythms, there is limited research on the consequences of long-term exposure to shift-work light conditions. Rodents can provide valuable insights into these effects. This study aimed to examine how short- or long-term exposure to rotating shifts and chronic jetlag affects the core circadian oscillators in the liver and skin of mammals. Methods: C57BL/6J male mice were subjected to simulated shift-work light conditions, including short-term or long-term rotating shifts and chronic jet-lag conditions. Liver and skin samples were collected every four hours over a 24-hour period on the second day of constant darkness. RNA was extracted and qRT-PCR analysis was conducted to measure the circadian gene expression in liver and skin tissues. Circadian rhythm analysis using CircaCompare compared the control group to mice exposed to shift-work light conditions. Results: The liver's circadian clock is significantly altered in mice under long-term rotating shift conditions, with a lesser but still noticeable impact in mice experiencing chronic jetlag. However, short-term rotating shift conditions do not significantly affect the liver's circadian clock. Conversely, all three simulated shift conditions affect the skin's circadian clock, indicating that the skin clock is more sensitive to shift-work light conditions than the liver clock. Compared to the liver, the skin's circadian clock is greatly affected by long-term rotating shift conditions. Conclusions: The study findings indicate more pronounced disturbances in the canonical clock genes of the skin compared to the liver under simulated shift-work light conditions. These results suggest that the skin clock is more vulnerable to the effects of shift-work.