bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group
Authors: Ursini Francesco , Ruscitti Piero , Addimanda Olga , Foti Rosario , Raimondo Vincenzo , Murdaca Giuseppe , Caira Virginia , Pigatto Erika , Cuomo Giovanna , Lo Gullo Alberto , Cavazzana Ilaria , Campochiaro Corrado , Naclerio Caterina , De Angelis Rossella , Ciaffi Jacopo , Mancarella Luana , Brusi Veronica , Marchetti Elena , Motta Francesca , Visentini Marcella , Lorusso Sebastiano , De Santis Maria , De Luca Giacomo , Massaro Laura , Olivo Domenico , Pellegrini Roberta , Francioso Francesca , Luppino Jessica , Di Cola Ilenia , Foti Roberta , Varcasia Giuseppe , Caso Francesco , Reta Massimo , Dagna Lorenzo , Selmi Carlo , Iagnocco Annamaria , Giacomelli Roberto , Iannone Florenzo , Ferri Clodoveo 
Published: June 2023

ObjectivesTo better define the spectrum of new-onset post-COVID-19 and post-COVID-19 vaccine inflammatory rheumatic diseases (IRD) from a large multicentric observational study.MethodsConsecutive cases of IRD encountered during a 12-month period and satisfying one of the following inclusion criteria: (a) onset of the rheumatic manifestations within 4 weeks from SARS-CoV-2 infection or (b) onset of the rheumatic manifestations within 4 weeks from the administration of one of the COVID-19 vaccines ws recruited.ResultsThe final analysis cohort comprised 267 patients, of which 122 (45.2%) in the post-COVID-19 and 145 (54.8%) in the postvaccine cohort. Distribution of IRD categories differed between the two cohorts: the post-COVID-19 cohort had a higher percentage of patients classified as having inflammatory joint diseases (IJD, 52.5% vs 37.2%, p=0.013) while the post-vaccine cohort had a higher prevalence of patients classified as polymyalgia rheumatica (PMR, 33.1% vs 21.3%, p=0.032). No differences were detected in the percentage of patients diagnosed with connective tissue diseases (CTD 19.7% vs 20.7%, p=0.837) or vasculitis (6.6% vs 9.0%, p=0.467). Despite the short follow-up period, IJD and PMR patients’ response to first-line therapy was favourable, with both groups achieving a drop in baseline disease activity scores of ~30% and ~70% respectively.ConclusionOur article reports the largest cohort published to date of new-onset IRD following SARS-CoV-2 infection or COVID-19 vaccines. Although causality cannot be ascertained, the spectrum of possible clinical manifestations is broad and includes IJD, PMR, CTD and vasculitis.
Gold Nanostars Obviate Limitations to Laser Interstitial Thermal Therapy (LITT) for the Treatment of Intracranial Tumors
Authors: Srinivasan Ethan S. , Liu Yang , Odion Ren A. , Chongsathidkiet Pakawat , Wachsmuth Lucas P. , Haskell-Mendoza Aden P. , Edwards Ryan M. , Canning Aidan J. , Willoughby Gavin , Hinton Joseph , Norton Stephen J. , Lascola Christopher D. , Maccarini Paolo F. , Mariani Christopher L. , Vo-Dinh Tuan , Fecci Peter E. 
Published: June 2023

Abstract

Purpose:
Laser interstitial thermal therapy (LITT) is an effective minimally invasive treatment option for intracranial tumors. Our group produced plasmonics-active gold nanostars (GNS) designed to preferentially accumulate within intracranial tumors and amplify the ablative capacity of LITT.

Experimental Design:
The impact of GNS on LITT coverage capacity was tested in ex vivo models using clinical LITT equipment and agarose gel–based phantoms of control and GNS-infused central “tumors.” In vivo accumulation of GNS and amplification of ablation were tested in murine intracranial and extracranial tumor models followed by intravenous GNS injection, PET/CT, two-photon photoluminescence, inductively coupled plasma mass spectrometry (ICP-MS), histopathology, and laser ablation.

Results:
Monte Carlo simulations demonstrated the potential of GNS to accelerate and specify thermal distributions. In ex vivo cuboid tumor phantoms, the GNS-infused phantom heated 5.5× faster than the control. In a split-cylinder tumor phantom, the GNS-infused border heated 2× faster and the surrounding area was exposed to 30% lower temperatures, with margin conformation observed in a model of irregular GNS distribution. In vivo, GNS preferentially accumulated within intracranial tumors on PET/CT, two-photon photoluminescence, and ICP-MS at 24 and 72 hours and significantly expedited and increased the maximal temperature achieved in laser ablation compared with control.

Conclusions:
Our results provide evidence for use of GNS to improve the efficiency and potentially safety of LITT. The in vivo data support selective accumulation within intracranial tumors and amplification of laser ablation, and the GNS-infused phantom experiments demonstrate increased rates of heating, heat contouring to tumor borders, and decreased heating of surrounding regions representing normal structures.
Functional Genetic Variants in TGFβ1 and TGFβR1 in miRNA-Binding Sites Predict Outcomes in Patients with HPV-positive Oropharyngeal Squamous Cell Carcinoma
Authors: Niu Zihao , Sun Peng , Liu Hongliang , Wei Peng , Wu Jia , Huang Zhigang , Gross Neil D. , Shete Sanjay , Wei Qingyi , Zafereo Mark E. , Calin George A. , Li Guojun 
Published: June 2023

Abstract

Purpose:
TGFβ1 and TGFβ receptor 1 (TGFβR1) participate in regulation of the host's immune system and inflammatory responses and may serve as prognostic biomarkers for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC).

Experimental Design:
This study included 1,013 patients with incident OPSCC, of whom 489 had tumor HPV16 status determined. All patients were genotyped for two functional polymorphisms: TGFβ1 rs1800470 and TGFβR1 rs334348. Univariate and multivariate Cox regression models were performed to evaluate associations between the polymorphisms and overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS).

Results:
Patients with TGFβ1 rs1800470 CT or CC genotype had 70%–80% reduced risks of OS, DSS, and DFS compared with patients with TT genotype, and patients with TGFβR1 rs334348 GA or GG genotype had 30%–40% reduced risk of OS, DSS, and DFS compared with patients with AA genotype. Furthermore, among patients with HPV-positive (HPV+) OPSCC, the same patterns were observed but the risk reductions were greater: up to 80%–90% for TGFβ1 rs1800470 CT or CC genotype and 70%–85% for TGFβR1 rs334348 GA or GG genotype. The risk reductions were still greater (up to 17 to 25 times reduced) for patients with both TGFβ1 rs1800470 CT or CC genotype and TGFβR1 rs334348 GA or GG genotype compared with patients with both TGFβ1 rs1800470 TT genotype and TGFβR1 rs334348 AA genotype among patients with HPV+ OPSCC.

Conclusions:
Our findings indicate that TGFβ1 rs1800470 and TGFβR1 rs334348 may individually or jointly modify risks of death and recurrence in patients with OPSCC, particularly those with HPV+ OPSCC undergoing definitive radiotherapy, and may serve as prognostic biomarkers, which could lead to better personalized treatment and improved prognosis.
Incidence of Stroke in the Aboriginal and Non-Aboriginal Populations of Australia: A Data Linkage Study
Authors: Balabanski Anna H. , Nedkoff Lee , Brown Alex , Thrift Amanda G. , Pearson Odette , Guthridge Steven , Dos Santos Angela , Kleinig Timothy J. , Katzenellenbogen Judith M. 
Published: June 2023

BACKGROUND:
Most estimates of stroke incidence among Aboriginal and Torres Strait Islander (hereinafter Aboriginal) Australians are confined to single regions and include small sample sizes. We aimed to measure and compare stroke incidence in Aboriginal and non-Aboriginal residents across central and western Australia.

METHODS:
Whole-population multijurisdictional person-linked data from hospital and death datasets were used to identify stroke admissions and stroke-related deaths (2001–2015) in Western Australia, South Australia, and the Northern Territory. Fatal (including out-of-hospital deaths) and nonfatal incident (first-ever) strokes in patients aged 20-84 years were identified during the 4-year study period (2012–2015), using a 10-year lookback period to exclude people with prior stroke. Incidence rates per 100 000 population/year were estimated for Aboriginal and non-Aboriginal populations, age-standardized to the World Health Organization World Standard population.

RESULTS:

In a population of 3 223 711 people (3.7% Aboriginal), 11 740 incident (first-ever) strokes (20.6% regional/remote location of residence; 15.6% fatal) were identified from 2012 to 2015, 675 (5.7%) in Aboriginal people (73.6% regional/remote; 17.0% fatal). Median age of Aboriginal cases (54.5 years; 50.1% female) was 16 years younger than non-Aboriginal cases (70.3 years; 44.1% female;
P
<0.001), with significantly greater prevalence of comorbidities. Age-standardized stroke incidence in Aboriginal people (192/100 000 [95% CI, 177–208]) was 2.9-fold greater than in non-Aboriginal people (66/100 000 [95% CI, 65–68]) aged 20-84 years; fatal incidence was 4.2-fold greater (38/100 000 [95% CI, 31–46] versus 9/100 000 [95% CI, 9–10]). Disparities were particularly apparent at younger ages (20–54 years), where age-standardized stroke incidence was 4.3-fold greater in Aboriginal people (90/100 000 [95% CI, 81–100]) than non-Aboriginal people (21/100 000 [95% CI, 20–22]).

CONCLUSIONS:
Stroke occurred more commonly, and at younger ages, in Aboriginal than non-Aboriginal populations. Greater prevalence of baseline comorbidities was present in the younger Aboriginal population. Improved primary prevention is required. To optimize stroke prevention, interventions should include culturally appropriate community-based health promotion and integrated support for nonmetropolitan health services.
Redescription of Naricolax stocki (Roubal, 1981) (Copepoda, Cyclopoida, Bomolochidae) recovered from Acanthopagrus schlegelii (Bleeker, 1854) (Actinopterygii) in Japan, with the description of its copepodid V
Authors: Izawa Kunihiko 
Published: June 2023

Abstract
Naricolax stocki (Roubal, 1981) is redescribed based on specimens of both sexes, recovered from the blackhead seabream Acanthopagrus schlegelii (Bleeker, 1854) (Perciformes, Sparidae) in Japan. Both sexes of its copepodid V are described for the first time.
Changes during early copepodid development of podoplean copepods: common ancestry or convergence
Authors: Ferrari Frank D. , von Vaupel Klein J. Carel 
Published: June 2023

Abstract
Examples are given of parasitic podopleans that change behaviour, and often morphology, between the first and second copepodid stages. The first copepodid is free-swimming, dispersive and infective; the second copepodid is found attached to or within its host and usually has undergone changes in morphology. Among free-living podopleans, changes in behaviour but not morphology are documented. Strengths and weaknesses of different evolutionary explanations are considered for these changes, including descent from a common free-living ancestor, convergences from several free-living ancestors, or a mixed model. More observations of free-living podopleans, like harpacticoids and cyclopoids, closely associated with the benthos, would be particularly valuable in testing each explanation.
Effects of salinity on growth and related indicators of gonadal development in Exopalaemon carinicauda (Decapoda, Caridea, Palaemonidae)
Authors: Pang Zhiyu , Zhao Zhenhui , Gao Jiayi , Deng Deng , Deng Kangyu , Xu Jing , Gao Huan 
Published: June 2023

Abstract
To explore the effects of salinity on the growth and gonadal development of Exopalaemon carinicauda, shrimps were raised at five different levels of salinity (16, 20, 24, 28, 32) in a water environment. The growth, performance in ovarian development, ovarian nutrient concentration, as well as vitellogenin and sex hormone levels were measured. The results showed that the final body weight and specific growth rate of E. carinicauda increased at first and then decreased with increasing salinity (), with the fastest growth occurring at salinity 24. The gonadosomatic index increased at first and then decreased with increasing salinity (), with the highest index also occurring at salinity 24. The ovarian maturation rate of E. carinicauda was highest at salinity 28, and the concentration of total protein, total cholesterol, and triglycerides in the ovaries similarly increased at first until salinity 24, and then decreased with increasing salinity (). Likewise, the concentration of vitellogenin in the hepatopancreas increased at first and then decreased with increasing salinity (), with the highest concentration occurring at salinity 24. The concentration of estradiol in E. carinicauda ovaries was highest in the groups at salinities 24 and 28. These results show that salinity levels of 24-28 were the most suitable for promoting the maturation of parent shrimps, and thus would likely be optimal for industrial culturing.
Majority-Minority Relations and Targeted Violence
Authors: Amin Husnul , Muhammad Niaz 
Published: June 2023

Abstract
Using a conflict model to analyse Majority-Minority relations (M-M), this paper focuses on the Hazara community in Afghanistan. Assuming M-M relations are power relations, the struggle for control among divergent ethnic groups has persisted. The Hazaras have historically resided in several provinces and experienced various forms of targeted violence. Millions have fled to other countries to escape persecution. This research diverges from dominant approaches that focus only on ethnicity and religion as the causes of violence against the Hazaras. Instead, the paper examines other factors that have been largely neglected by conflict studies literature. Based on historical data, the study finds that the Hazaras’ geostrategic location in Afghanistan, their alliances with Pashtun tribes, and their struggle for autonomy have been the primary factors contributing to the targeted violence against them. Therefore, while ethnicity and religion may have made the Hazaras vulnerable to violence, they are not the main causes of violence.
“To Draw a Body, Human or Beast, One Must Study Anatomy”
Authors: Didouan Amandine Victoria 
Published: June 2023

Abstract
Contributing to the merging fields of art history, visual culture, and history of science, this article brings forward Carlo Ruini’s (1530–1598) equine anatomical treatise Dell’Anotomia et dell’Infermità del Cavallo (1598). The introduction of Ruini’s epistemic imagery, specifically a flayed horse depicted in what has been termed the “foreshortened-frontalized-equestrian” pose, offers a new perspective to existing art historical scholarship, hypothesising on the role of anatomy in depictive choices within early modern equestrian portraiture. The anatomical poses and postures originally found in Dell’Anotomia reappear in portraits of equine subjects by Rubens and his followers thus challenging currently held academic theories concerning their source of inspiration. The application of elements from Ruini’s Dell’Anotomia within a seventeenth-century practical guide for artists further underscores anatomy’s influence on equestrian portraiture, thus evidencing a deliberate response to the relationship between science, early modern equestrian culture, and art.
“Put the Brassiere on the Cross”
Authors: Peretz Jeremy Jacob 
Published: June 2023

Abstract
Komfa is a Guyanese practice involving elaborate rituals dedicated to “the Seven Nations” of ancestor-spirits who re/present colonial British demography. Komfa’s Spanish nation is most frequently understood as presenting queer subjecthood through overtly sexualized and (trans)gendered performances. To Guyanese, “Spanish” generally refers to Venezuelans. Pre- and post-emancipation histories of mobility within the borderlands of Guyana and Venezuela illuminate how Komfa practitioners embrace ambiguities of “noncompliant” genders and sexualities. Devotees who embody Spanish spirits tend to be transgender, identify as gay or antiman, and/or share intimate relations with partners of the same sex. Many also engage in sex labor. Such orientations, identifications, and occupations performed during trance possession and “secular” contexts of daily life may be re-valued through Komfa, providing non-conforming Guyanese with a refuge from societal discriminations through which they transform conceptions of selfhood by embracing the agencies and lived experiences of “non-Guyanese” within a symbolic economy of erotic alterity.
Towards a New Reconstruction of the Proto-Yeniseian Sound System. Part I: Word-Initial Consonants
Authors: Bonmann Svenja , Fries Simon , Korobzow Natalie , Günther Laura , Hill Eugen 
Published: June 2023

Abstract
We present correspondence sets involving word-initial consonants and including all known members of the Yeniseian language family. The data can be used for a systematic application of the comparative method, implying both the reconstruction of proto-phonemes and subsequent phylogenetic research questions (intrafamilial subdivisions among the Yeniseian languages according to shared phonological innovations). Key findings include (I) the discovery of an isogloss which separates Ket, Yugh and Pumpokol from Kott, Assan and Arin in terms of word-initial labial and dental plosives (voiced in the former group, voiceless in the other) and (II) the inference that Proto-Yeniseian (PY), i.e., the last common ancestor of all Yeniseian languages, probably had a two-layered system of plain voiced and plain voiceless stops. We do not see evidence for the postulation of lateral affricates. In addition, there are three correspondences of sibilants and uvulars, respectively, but we cannot, as yet, plausibly posit proto-phonemes in these cases.
Unpacking the Idea of Modernization of Chinese-Style Higher Education: A Policy Narrative Analysis
Authors: Li Jian , He Yunshu 
Published: June 2023

Abstract
Higher education in China is the high-end and leading part of the whole education system. The development height of higher education to some extent represents and determines the height of national development. China’s higher education plays an irreplaceable and decisive strategic role in the realization of Chinese-style modernization. This study explores the idea of modernization of Chinese-style higher education from the perspective of a policy narrative analysis. The background of the modernization of Chinese higher education, the core idea of modernization of Chinese higher education, connotation, and characteristics of the modernization of Chinese higher education have been analyzed in this study.
Acromioclavicular Joint Space Size in a Nigerian Patient cohort
Authors: Olanipekun H. L. , Ohagwu C. C. , Okonkwo P. O. , Ikegwuonu N. C. , Egwuanumku K. I. , Ezugwu E. E. 
Published: June 2023

Objective: To establish normative data on the width of the acromioclavicular (AC) joint space using sonography, based on a selected Nigerian cohort without any shoulder injury or pathology. Materials and Methods: A cross-sectional study was conducted on the normal AC joints of randomly selected Nigerians. A sonographer performed the examination and obtained all the width measurements of AC joint space, using a GE LOGIQP6 ultrasound system and a multiple-frequency linear transducer. Results: The width of the AC joint space was equal on both sides, measuring 5.6 ± 1.2 mm for the right and 5.6 ± 1.2 mm for the left ( P = .701). The mean width of both joint spaces differed between men and women, with the men having a wider space ( P < .05). Age had a strong negative predictive relationship, with the AC joint space width and both joint spaces decreasing with age ( P < .001). Weight and body mass index had weak negative predictive relationships with both joint space widths ( P < .001). Participant height had a very weak positive predictive relationship with both joint space widths ( P < .05). Conclusion: Normative data on the width of the AC joint space, in a randomly selected Nigerian cohort, are provided and may be clinically useful in the ongoing sonographic assessment of the AC joint.
Patterns of physical activity over time in older patients rehabilitating after hip fracture surgery: a preliminary observational study
Authors: van Dartel Dieuwke , Wang Ying , Hegeman Johannes H. , Vermeer Marloes , Vollenbroek-Hutten Miriam M. R. ,   on behalf of the Up&Go after a hip fracture group, Broersma B. , Brouwer K. , Folbert E. C. , Gerrits T. , Gommers S. M. , Harperink A. J. M. , Hofstra P. T. , Kemerink op Schiphorst M. M. , Lammerink-Smienk N. M. , Luttje M. P. , Marissen-Heuver D. K. , Mars P. M. M. , Nijhuis-Geerdink M. A. H. , Nijmeijer W. S. , Oude Luttikhuis A. H. S. , Oude Weernink T. M. , de Pagter C. , Schokker-Viergever J. , Vlaskamp R. T. J. , Voortman M. , Woudsma S. 
Published: June 2023

Abstract
Background
To investigate patterns of continuously monitored physical activity in older patients rehabilitating after hip fracture surgery and the association with patient characteristics.

Methods
Physical activity of surgically treated hip fracture patients aged 70 years or older, who were rehabilitating at a skilled nursing home, was continuously monitored using a tri-axial accelerometer. The intensity of physical activity per day was calculated from the accelerometer signals to describe the daily physical activity levels of the enrolled patients. The patterns of three different aspects of physical activity were investigated: overall physical activity, overall variability, and day-to-day variability. Two experts in the geriatric rehabilitation field helped identifying unique physical activity patterns for each aspect based on visual analysis. Eighteen healthcare professionals independently classified each patient in one of the predefined patterns for each aspect. Differences between physical activity patterns and patient characteristics were assessed using a Kruskal–Wallis or Fisher’s Exact Test.

Results
Physical activity data from 66 older patients were used in this preliminary study. A total of six unique patterns were identified for overall physical activity and overall variability, and five unique patterns for the day-to-day variability. The most common pattern found for the overall physical activity and day-to-day variability had a S-shape, which first slowly increased, then steeply increased, and subsequently flattened (n = 23, 34.8%). A N-shape pattern was found the most common pattern for overall variability, which first slowly increased, then steeply increased, then decreased and lastly increased (n = 14, 21.2%). The functionality at admission to rehabilitation, measured with the Barthel Index, and the duration of rehabilitation stay differed between the patterns of physical activity.

Conclusions
Multiple patterns of physical activity among older patients during hip fracture rehabilitation were found in this preliminary study. The functionality at admission to rehabilitation and the duration of rehabilitation stay were associated with the different patterns found in this study. Results of this study highlight the importance of personalized hip fracture treatment.