bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological and survival outcomes of 4L lymph node dissection in left lung adenocarcinoma and squamous cell carcinoma
Authors: Shen Leilei , Guo Juntang , Zhang Weidong , Liang Chaoyang , Chen Han , Liu Yang 
Published: April 2023

BackgroundWhether 4L lymph node dissection (LND) should be performed remains unclear and controversial. Prior studies have found that station 4L metastasis was not rare and that 4L LND may provide survival benefits. The objective of this study was to analyze the clinicopathological and survival outcomes of 4L LND from the perspective of histology.MethodsThis retrospective study included 74 patients with squamous cell carcinoma (SCC) and 84 patients diagnosed with lung adenocarcinoma (ADC) between January 2008 and October 2020. All patients underwent pulmonary resection with station 4L LND and were staged as T1-4N0-2M0. Clinicopathological features and survival outcomes were investigated based on histology. The study endpoints were disease-free survival (DFS) and overall survival (OS).ResultsThe incidence rate of station 4L metastasis was 17.1% (27/158) in the entire cohort, with 8.1% in the SCC group, and 25.0% in the ADC group. No statistical differences in the 5-year DFS rates (67.1% vs. 61.7%, P=0.812) and 5-year OS rates (68.6% vs. 59.3%, P=0.100) were observed between the ADC group and the SCC group. Multivariate logistic analysis revealed that histology (SCC vs. ADC: OR, 0.185; 95% CI, 0.049–0.706; P=0.013) was independently associated with 4L metastasis. Multivariate survival analysis showed that the status of 4L metastasis was an independent factor for DFS (HR, 2.563; 95% CI, 1.282–5.123; P=0.008) but not for OS (HR, 1.597; 95% CI, 0.749–3.402; P=0.225).ConclusionStation 4L metastasis is not rare in left lung cancer. Patients with ADC have a greater predilection for station 4L metastasis and may benefit more from performing 4L LND.
Diagnostic value of combination of biomarkers for malignant pleural mesothelioma: a systematic review and meta-analysis
Authors: Zhu Mucheng , Lu Zhenhua , Guo Hao , Gu Xiaoting , Wei Defang , Zhang Zhengyi 
Published: April 2023

IntroductionEarly-stage accurate diagnosis of malignant pleural mesothelioma (MPM) has always been a formidable challenge. DNA and protein as biomarkers for the diagnosis of MPM have received considerable attention, and yet the outcomes are inconsistent.MethodsIn this study, a systematic search employing PubMed, EMBASE, and Cochrane Library to identify relevant studies from the first day of databases to October 2021. Moreover, we adopt the QUADAS-2 to evaluate the quality of eligible studies and Stata 15.0 and Review Manager 5.4 software programs to perform the meta-analysis. Additionally, bioinformatics analysis was performed at GEPIA for the purpose of exploring relationship between related genes and the survival time of MPM patients.ResultsWe included 15 studies at the DNA level and 31studies at the protein level in this meta-analysis. All results demonstrated that the diagnostic accuracy of the combination of MTAP + Fibulin-3 was the highest with the SEN 0.81 (95% CI: 0.67, 0.89) and the SPE 0.95 (95% CI: 0.90, 0.97). And the bioinformatics analysis indicated that the higher MTAP gene expression level was beneficial to enhance the survival time of MPM patients.DiscussionNonetheless, as a result of the limitations of the included samples, it may be necessary to conduct additional research before drawing conclusions.Systematic review registrationhttps://inplasy.com/inplasy-2022-10-0043/, identifier INPLASY2022100043.
Primary ectopic meningioma in the thoracic cavity: A rare case report and review of the literature
Authors: Liu Xu , Liu Jiao , Nai Ting , Yang Yuxia , Hu Yuchang 
Published: April 2023

BackgroundMeningioma is a common type of intracranial tumor in adults. It rarely arises in the chest, with only a few case reports in the English literature. Here, we report the case of a patient with a primary ectopic meningioma (PEM) located in the thoracic cavity.Case presentationA 55-year-old woman presented with exercise-induced asthma, chest tightness, intermittent dry cough and fatigue for several months. Computed tomography revealed the presence of a huge mass in the thoracic cavity, with no connection to the spinal canal. Lung cancer and mesothelioma were suspected, and surgery was performed. Grossly, the mass was a grayish-white solid 9.5 cm × 8.4 cm × 5.3 cm in size. The microscopic morphology of the lesion was consistent with that of typical central nervous system meningioma. The pathological subtype was transitional meningioma. The tumor cells were arranged in a fascicular, whorled, storiform and meningithelial pattern, with occasional intranuclear pseudo-inclusions and psammoma bodies. In focal areas tumor cells were considerably dense, and the cells were round or irregular in shape, with less cytoplasm, uniform nuclear chromatin, and visible nucleoli and mitoses (2/10 HPF). By immunohistochemistry, the neoplastic cells showed strong and diffuse staining with vimentin, epithelial membrane antigen and SSTR2 with variable expression of PR, ALK and S100 protein. However, the cells were negative for GFAP, SOX-10, inhibin, CD34, STAT6, smooth muscle actin, desmin, CKpan, D2-40, WT-1, CK5/6 and CD45. The highest proliferation index by Ki-67 was 15%. The abnormal expression of ALK led to the initial misdiagnosis of an inflammatory myofibroblastic tumor. After 12 months of follow-up, no disease progression was observed.ConclusionThe presence of primary ectopic meningiomas in the thoracic cavity is extremely rare, and this tumor is easily misdiagnosed clinically. Imaging is suggested to determine the location and possible differential diagnosis, while the final diagnosis should be via pathological examination. Immunohistochemistry is crucial for disease diagnosis. Owing to our limited knowledge of PEM, its pathogenesis and tissue of origin remain unclear. Clinicians should pay close attention to such potential patients. The present case report may provide insights into the diagnosis and therapy of patients with this tumor.
Dietary ketone ester attenuates the accretion of adiposity and liver steatosis in mice fed a high-fat, high-sugar diet
Authors: Rushing Kelsey A. , Bolyard Mickey L. , Kelty Taylor , Wieschhaus Nicole , Pavela Gregory , Rector R. Scott , Plaisance Eric P. 
Published: April 2023

Objective: The ketone diester, R,S-1,3-butanediol diacetoacetate (BD-AcAc2), attenuates the accretion of adiposity and reduces hepatic steatosis in high-fat diet-induced obese mice when carbohydrate energy is removed from the diet to accommodate energy from the ester. Reducing carbohydrate energy is a potential confounder due to the well-known effects of carbohydrate restriction on components of energy balance and metabolism. Therefore, the current investigation was designed to determine whether the addition of BD-AcAc2 to a high-fat, high-sugar diet (with no reduction in carbohydrate energy) would attenuate the accretion of adiposity and markers of hepatic steatosis and inflammation.Methods: Sixteen 11-week-old male C57BL/6J mice were randomized to one of two groups for 9 weeks (n = 8 per group): 1) Control (CON, HFHS diet) or 2) Ketone ester (KE, HFHS diet + BD-AcAc2, 25% by kcals).Results: Body weight increased by 56% in CON (27.8 ± 2.5 to 43.4 ± 3.7 g, p &lt; 0.001) and by 13% in KE (28.0 ± 0.8 to 31.7 ± 3.1 g, p = 0.001). Non-alcoholic fatty liver disease activity scores (NAS) for hepatic steatosis, inflammation, and ballooning were lower in the KE group compared to CON (p &lt; 0.001 for all). Markers of hepatic inflammation [Tnfα (p = 0.036); Mcp1 (p &lt; 0.001)], macrophage content [(Cd68 (p = 0.012)], and collagen deposition and hepatic stellate cell activation [(αSma (p = 0.004); Col1A1 (p &lt; 0.001)] were significantly lower in the KE group compared to CON.Conclusion: These findings extend those of our previous work and show that BD-AcAc2 attenuates the accretion of adiposity and reduces markers of liver steatosis, inflammation, ballooning, and fibrosis in lean mice placed on a HFHS diet where carbohydrate energy was not removed to accommodate energy from addition of the diester.
Inequality and barriers in psychosis prevention: A systematic review on clinical high-risk for psychosis studies from developing countries
Authors: Loch Alexandre Andrade , Lopes-Rocha Ana Caroline , Fekih-Romdhane Feten , van de Bilt Martinus Theodorus , Salazar de Pablo Gonzalo , Fusar-Poli Paolo 
Published: April 2023

BackgroundThe clinical high-risk for psychosis (CHR) paradigm is one of the best studied preventive paradigms in psychiatry. However, most studies have been conducted in high-income countries. It is unclear if knowledge from such countries applies to low and middle-income countries (LAMIC), and if there are specific limitations hindering CHR research there. Our aim is to systematically review studies on CHR from LAMIC.MethodsA multistep PRISMA-compliant literature search was performed in PubMed and Web of Science for articles published until 1/03/2022, conducted in LAMIC, addressing the concept and correlates of CHR. Study characteristics as well as limitations were reported. Corresponding authors of the included studies were invited to answer an online poll. Quality assessment was done with the MMAT.ResultsA total of 109 studies were included in the review: none from low-income countries, 8 from lower middle-income countries, and 101 from upper middle-income countries. The most frequent limitations were small sample size (47.9%), cross-sectional design (27.1%), and follow-up issues (20.8%). Mean quality of included studies was of 4.4. Out of the 43 corresponding authors, 12 (27.9%) completed the online poll. They cited further limitations as few financial resources (66.7%), no involvement of population (58.2%) and cultural barriers (41.7%). Seventy five percent researchers reported that CHR research should be conducted differently in LAMIC compared to high-income countries, due to structural and cultural issues. Stigma was mentioned in three out of five sections of the poll.DiscussionResults show the discrepancy of available evidence on CHR in LAMIC, given the shortage of resources in such countries. Future directions should aim to increase the knowledge on individuals at CHR in such settings, and to address stigma and cultural factors that may play a role in the pathways toward care in psychosis.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=316816, CRD42022316816.
Type D personality to insomnia: Sleep reactivity, sleep effort, and sleep hygiene as mediators
Authors: Uygur Omer Faruk , Ahmed Oli , Uygur Hilal , Bahar Aynur , Hursitoglu Onur , Chung Seockhoon , Drake Christopher L. 
Published: April 2023

BackgroundInsomniacs are heterogenous group with very diverse personalities. We aimed to investigate the mediating role of sleep reactivity (SR), sleep hygiene (SH), and sleep effort (SE) in the relationship between Type D personality and insomnia.Materials and methodsWe conducted a cross-sectional survey among 474 participants. The survey comprised the sociodemographic data form, Insomnia Severity Index (ISI), D Type Personality Scale (DS-14), Ford Insomnia Response to Stress Test (FIRST), Glasgow Sleep Effort Scale (GSES), and Sleep Hygiene Index (SHI). We conducted hierarchical multiple regression analysis to identify the associations between age, sex, SR, Type D personality traits, SE, SH, and insomnia severity. We subsequently conducted mediation analyses to examine whether SR, SH, and SE mediated the relationship between Type D personality and insomnia.ResultsISI, DS-14, FIRST, SHI, and GSES scores were significantly higher in individuals with Type D personality. Female sex, SR, Type D personality traits, SE, and SH explained 45% of the variance in insomnia severity. When age, sex, insomnia response to stress, and Type D personality traits were controlled, SE and SH significantly explained 25% of the variance in insomnia severity (R2 = 0.45, R2 change = 0.25, F (6.474) = 65.58, p &lt; 0.001). SR, SE, and SH each played a partial mediating role between Type D personality and insomnia.ConclusionThe findings showed that individuals with Type D personality had high SR and that individuals with a higher number of these personality traits exhibited more severe insomnia symptoms through high SR, greater SE, and worse SH.
Effect of replacing whole wheat with broken rye as a sustainable grain in diets of fattening turkeys on growth performance, litter quality, and foot pad health
Authors: Lingens Jan Berend , Visscher Christian , Sürie Christian , Grone Richard , von Felde Andreas , Wilke Volker , Abd El-Wahab Amr 
Published: April 2023

IntroductionRye is one of the most important cereal crops in Central Europe, thus attempts have been made to include it in the diets of birds to reduce production costs, since the cost of feed accounts for as much as 50 %−70 % thereof. Nevertheless, the use of rye has been limited to date, particularly in turkeys. This study aimed to test the effects of rye inclusion up to 10 % on growth, excreta, and/or litter dry matter, and foot pad health.MethodsFour trials were performed with a total of 4,322, 4,307, 4,256, and 4,280 female turkeys (BUT BIG 6, Aviagen) for trials 1, 2, 3, and 4, respectively. All birds were fed commercial starter diets for the dietary phases 1 and 2 (up to d 35 of life). Thereafter, at the start of the study, the control group received commercial supplementary feed with 5 % or 10 % wheat until the end of the fattening period. The experimental group was offered supplementary feed to which instead of wheat increasing levels of rye were added stepwise from 5 % to 10 %.ResultsUsing supplementary feed with rye showed no significant differences in the final body weight between the control and experimental groups (10.9 vs. 10.8 kg). The dry matter content of fresh excreta for turkeys during the experimental period did not show significant differences between both groups, except at weeks 10 and 14 of life. The feed type (either control diet or experimental diet) did not significantly affect litter dry matter content between the groups throughout the experimental period. No significant differences were noted in food pad dermatitis scoring between both groups throughout the experimental period, except at weeks 11 and 16 of life. Overall, this study showed that including proportions of rye up to 10% could replace conventional ingredients and may increase sustainability in poultry production regardless of the addition of supplementary feed.
Combination of Farnesol with Common Antifungal Drugs: Inhibitory Effect against Candida Species Isolated from Women with RVVC
Authors: Nikoomanesh Fatemeh , Falahatinejad Mahsa , Černáková Lucia , dos Santos André Luis Souza , Mohammadi Shahla Roudbar , Rafiee Mitra , Rodrigues Célia Fortuna , Roudbary Maryam 
Published: April 2023

Background and Objectives: Vulvovaginal candidiasis (VVC) is a mucous membrane infection, with an increased rate of antifungal resistance of Candida species. In this study, the in vitro efficacy of farnesol alone or in combination with traditional antifungals was assessed against resistant Candida strains recovered from women with VVC. Materials and Methods: Eighty Candida isolates were identified by multiplex polymerase chain reaction (PCR), and the antifungal susceptibility to amphotericin B (AMB), fluconazole (FLU), itraconazole (ITZ), voriconazole (VOR), clotrimazole (CTZ), and farnesol was tested by the standard microdilution method. The combinations of farnesol with each antifungal were calculated based on the fractional inhibitory concentration index (FICI). Result: Candida glabrata was the predominant species (48.75%) isolated from vaginal discharges, followed by C. albicans (43.75%), C. parapsilosis (3.75%), a mixed infection of C. albicans and C. glabrata (2.5%) and C. albicans and C. parapsilosis (1%). C. albicans and C. glabrata isolates had lower susceptibility to FLU (31.4% and 23.0%, respectively) and CTZ (37.1% and 33.3%, respectively). Importantly, there was “synergism” between farnesol–FLU and farnesol–ITZ against C. albicans and C. parapsilosis (FICI = 0.5 and 0.35, respectively), reverting the original azole-resistant profile. Conclusion: These findings indicate that farnesol can revert the resistance profile of azole by enhancing the activity of FLU and ITZ in resistant Candida isolates, which is a clinically promising result.
Representation and Difference
Authors: López-Yánez María Gabriela 
Published: April 2023

During the Atlantic slavery period enslaved and freed Africans and Afro-descendants populated principally two areas in Ecuador: the Chota-Mira valley (Imbabura and Carchi provinces) and the northern part of Esmeraldas province. Afrodescendants from these territories created two music and dance-based events; Bomba del Chota and Marimba Esmeraldeña. Since their arrival, Afro-descendants in Ecuador have had a history of dehumanization that continues until the present day. Based on the testimonies of the Marimberos and Bomberos included in this paper, archival compilation and fieldwork research, I address questions of racialized representations of Marimba and Bomba in order to build towards the notion of communicative competence. Here I propose the shift of some of the representations of Marimba and Bomba from the current focus on stereotypical characteristics such as a naturalized happiness and hyper-sexuality, to an emphasis on Afro-Ecuadorians’ collective memories. Through a sonic composition and its theorization, a questioning of coloniality that sustains racialized representations and the exposure of key, but usually silenced, collective memories is proposed. By developing a sonic composition and analyzing it, I aim to contribute with crucial theoretical and practical strategies to deepen a much needed and timely understanding of Marimba and Bomba

1) This paper and its sonic composition are bas ed on a chapter of my PhD thesis entitled “Sounds of collective memories: A decolonial counter- representation of Afro-Ecuadorian Marimba Esmeraldeña and Bomba del Chota” (López-Yánez, 2020). I dedicate this paper to one of the most renowned, charismatic and wise Afro-Ecuadorian artist, the Marimbero Guillermo Ayoví Erazo -Papá Roncón-, who passed away on September 30th, 2022, while I was writing it.
Effect of Process Variables and Zeolite Adsorbent in Coffee Bean Drying
Authors: Soeswanto Bambang , Edi Wahyuni Ninik Lintang , Prihandini Ghusrina , Pratama Yusuf , Firmansyah Taufik Akbar , Widyabudiningsih Dewi 
Published: April 2023

Green coffee beans to be stored for transportation must meet storage quality standards, especially the maximum moisture content of 12.5%, so the drying process must be carried out to achieve quality standards, but still economical. The study aims to obtain optimum operating conditions on the drying of Arabica-type coffee beans using a fluidized bed dryer assisted by zeolite adsorbents in a separated fluidized bed prior to heating, as well as calculating the energy consumption of blowers and air heater. The operating conditions were varied, namely air flow rate of 1.79 – 2.29 m/s, air temperature of 45 o C, 50 o C, and 55 o C, zeolite adsorbent mass of 150 g, 175 g, and 200 g. The coffee beans quality tests carried out were the moisture, carbohydrates, protein content, and the visual appearance of the beans. The results show that the optimum drying process of coffee beans resulting a minimum protein and carbohydrate damage are the air velocity of 2.1 m/s, air temperature of 55°C, drying time of 240 minutes, and zeolite adsorbent mass of 150 grams, with energy consumption of 5.02 KWH (equivalent to 180 MJ/T). The addition of zeolite as much as 150 grams, 175 grams, and 200 grams as adsorbent was able to reduce the relative humidity (RH) of air by 16.65%, 18.60%, and 21.17% respectively. The drying rate of coffee beans is mainly influenced by air temperature (more predominantly) than the adsorption of air humidity by zeolite.
PENGARUH INOVASI PRODUK, KUALITAS PRODUK, DAN BENTUK KEMASAN TERHADAP MINAT BELI PRODUK TAHU
Authors: Saputra Jaya Aji , Bahrun Khairul 
Published: April 2023

The title of this research is. The Effect of Product Innovation, Product Quality, and Packaging Form on Interest in Buying Tofu Products (a case study of umkm mak mus in Ujung Market, Kepahiang Regency). (case study of UMKM Mak Mus in Ujung Market, Kepahiang Regency) . This study uses a quantitative approach with data analysis techniques using multiple regression analysis. The population in this study were all MSME customers who knew Mak Mus, whose number was unknown, with a sample of 90 respondents. This study used the Simple Random Sampling technique. Product innovation, product quality and packaging form simultaneously have a significant effect on buying interest. Product innovation, product quality and packaging form partially have a significant effect on buying interest.
Keywords: Product Innovation, Product Quality, Safety Form, Buying Interest
PENGARUH STRES KERJA MOTIVASI DAN KOMPENSASI TERHADA KEPUASAN KERJA KARYAWAN CV. Central Elekro
Authors: Aftariansyah Walpindri , Ratnawili Ratnawili 
Published: April 2023

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