bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmentally appropriate mental health literacy content for school-aged children and adolescents
Authors: Kågström Anna , Juríková Laura , Guerrero Zoe 
Published: May 2023

AbstractAlthough improving the mental health of children and adolescents has become a global priority, resources outlining developmentally appropriate content for improving mental health literacy (MHL) across school-aged children are scarce. A comprehensive, life-course approach to building MHL is needed to address the evolving competencies, needs, capacities, and risk factors for mental health, especially to establish school-based interventions that can be equitably and sustainably implemented. We conducted a theoretical review highlighting the relation of research and practice in building MHL through developmentally appropriate knowledge and competencies for children and adolescents. A two-pronged review of the literature was conducted to provide an overview of (1) research with a focus on neurobiological, psychological, cognitive, and social developmental milestones of school-aged children relevant for building MHL and (2) evidence-based and theory-driven content for the development of universal MHL interventions for children and adolescents considering the four components of MHL. A map of relevant key milestones highlights the range of development that occurs and ample opportunity for increasing universal MHL during these sensitive years primed for learning. We reflect on current understandings and global considerations for MHL interventions with an emphasis on applying developmental science to the future strengthening of intervention development, uptake, adaptation, implementation, evaluation, and scale-up.
Stabilise and symmetrise the deformation of buckling metamaterial for tunable vibration bandgaps
Authors: Liu Encai , Fang Xin , Zhu Peidong , Wen Jihong 
Published: May 2023

Abstract
Mechanical metamaterials have attracted extensive attention. This paper reports a metamaterial with tunable elastic wave bandgaps based on bistable buckling structure. First, we find that deformation of two symmetric buckling shells is intrinsically asymmetric, which blocks the realisation of robust tunability. Based on an analytical model, we clarify that the mechanisms for this intrinsic asymmetricity are the bifurcations on force–deformation curves. Then we propose a superposition method of buckling shells, which can realise the symmetric deformation for robust tunable stiffness. Using this variable-stiffness oscillator, we design a metamaterial sandwich beam, and numerically and experimentally demonstrate its tunable bandgap for vibration suppression. This paper presents the unusual deformation process of buckling elements widely used for constructing metamaterials, and provides a robust way to realise metamaterials with tunable vibration bandgaps.
Temporal patterns of energy intake identified by the latent class analysis in relation to prevalence of overweight and obesity in Iranian adults
Authors: Jayedi Ahmad , Shafiei Neyestanak Mahdi , Djafarian Kurosh , Shab-Bidar Sakineh 
Published: May 2023

AbstractWe aimed to identify temporal patterns of energy intake and investigate their association with adiposity. We performed a cross-sectional study of 775 adults in Iran. Information about eating occasions across the day was collected by three 24-h dietary recalls. Latent class analysis (LCA) was used to identify temporal eating patterns based on whether or not an eating occasion occurred within each hour of the day. We applied binary logistic regression to estimate the OR and 95 % CI of overweight and obesity (defined as BMI of 25–29·9 and ≥ 30 kg/m2, respectively) across temporal eating patterns while controlling for potential confounders. LCA grouped participants into three exclusive sub-groups named ‘Conventional’, ‘Earlier breakfast’ and ‘Later lunch’. The ‘Conventional’ class was characterised by high probability of eating occasions at conventional meal times. ‘Earlier breakfast’ class was characterised by high probability of a breakfast eating occasion 1 h before the conventional pattern and a dinner eating occasion 1 h after the conventional pattern, and the ‘Later lunch’ class was characterised by a high probability of a lunch eating occasion 1 h after the conventional pattern. Participants in the ‘Earlier breakfast’ pattern had a lower likelihood of obesity (adjusted OR: 0·56, 95 % CI: 0·35, 0·95) as compared with the ‘Conventional’ pattern. There was no difference in the prevalence of obesity or overweight between participants in the ‘Later lunch’ and the ‘Conventional’ patterns. We found an inverse association between earlier eating pattern and the likelihood of obesity, but reverse causation may be a plausible explanation.
The study of bioavailability and endogenous circadian rhythm of menaquinone-7, a form of vitamin K2, in healthy subjects
Authors: Du Fan , Yan Min , Duan Lili , Xie Guolong , Yao Xiuhua , Hu Wenjing , Liu Yu , Meng Min , Chen Jiepeng , Shao Di 
Published: May 2023

AbstractMenaquinone-7 (MK-7), a multipotent vitamin K2, possesses a wide range of biological activities, a precise curative effect and excellent safety. A simple and rapid LC-APCI-MS/MS method for the determination of MK-7 in human plasma with single liquid–liquid extraction (LLE) extraction and 4·5-min analysis time has been developed and validated. Four per cent bovine serum albumin (BSA) was used as surrogate matrix for standard curves and endogenous baseline subtraction. This method was reproducible and reliable and was used to analyse of MK-7 in human plasma. The endogenous circadian rhythm and bioavailability of MK-7 were investigated in two randomised single-dose, open, one-way clinical trials (Study I and Study II). A total of five healthy male subjects were enrolled in Study I and 12 healthy male subjects in Study II. Single-dose (1 mg) of MK-7 was given to each subject under fasting condition, and all eligible subjects were given a restricting VK2 diet for 4 d prior to drug administration and during the trial. The experiment results of Study I demonstrated that endogenous MK-7 has no circadian rhythm in individuals. Both studies showed MK-7 are absorbed with peak plasma concentrations at about 6 h after intake and has a very long half-life time.
Irrigation pumps in late colonial Taiwan: Farmers’ utilization of technology and the transition to rice cultivation
Authors: Tsuru Shuntaro 
Published: May 2023

AbstractThis article describes how Taiwanese farmers adopted irrigation pumps to enhance their livelihoods under the shifting relationship of sugar and rice production in late colonial Taiwan. I argue that farmers utilized commercial technologies to make a living and prosper within the established order of Japanese colonial rule. With allocated procurement districts granting exclusive purchasing rights over sugarcane, sugar companies maintained substantial influence over sugarcane cultivation. However, with the proliferation of Penglai rice and new agricultural implements, the situation of the farmers changed substantially. Serious problems in the sugar industry due to economic depression and the rising price of rice in the 1930s led farmers to shift from sugarcane to rice cultivation by introducing a variety of pumps. Those with the means installed new motor pumps, while others independently constructed wind pumps by combining newly introduced parts with older techniques. Despite a prohibition by the colonial government, farmers continued installing pumps until the government established a planned economy in preparation for war. Moreover, distribution of pump capacity through both sales and sharing shows that Taiwanese farmers sought to maintain an informal yet significant cohesion throughout the process of agricultural commercialization. By focusing on the social dynamics surrounding agricultural technologies, this article challenges simplistic portrayals of technology transfer from Japan to the colonies.
The Uses and Abuses of Legal Pluralism: A View from the Sideline
Authors: Herzog Tamar 
Published: May 2023

AbstractThis text takes issue with how present day debates regarding legal pluralism affect our vision of the past, as well as limit the horizons of possibilities in the future. It suggests that the genealogy of these debates determined what would be seen, and what ignored, and that, as a result, it has privileged some aspects, while forgetting the importance of others.
Self-reported quality of life before, during, and after pregnancy in women with CHD
Authors: Wedlund Frida , Hlebowicz Joanna 
Published: May 2023

AbstractBackground:Adults with CHD are a growing patient group and childbirth is a relatively new phenomenon. EQ-5D is commonly used to measure health-related quality of life. We sought to investigate EQ-5D status before, during, and after pregnancy in women with CHD.Methods:We identified 128 pregnancies in 86 CHD women giving birth in Skåne County during 2009–2021. Repeated measures ANOVA was performed to test for differences between the five EQ-5D domains, EQ-VAS, and EQ-index over time points before, the second trimester, the third trimester, and after pregnancy.Results:Mean age at estimated childbirth was 30.3 (± 4.7) years; 56.25% of births were vaginal deliveries and 43.75% were Caesarean sections. The cohort consisted of patients with double outlet right ventricle (4.7%), transposition (Mustard/Senning 2.3%, arterial switch 4.7%), aortic anomalies (19.5%), Fallot’s anomaly (16.4%), single ventricle (3.9%), shunt lesions (11.7%), cardiomyopathies (4.7%), coronary anomalies (1.6%), arrythmias (0.8%), and valve lesions: aortic (19.5%), mitral (5.5%), and pulmonary (4.7%). The women reported significantly worse mobility (p = 0.007) and higher pain/discomfort (p = 0.049) at trimester 3 compared to before pregnancy. The women had lower EQ-5D index during trimester 3 compared to after pregnancy (p = 0.004). We saw worse mobility during Tri 2 comparing multiparity with primiparity (p = 0.046). Looking at delivery mode, we noted significantly higher anxiety/depression before pregnancy (p =0.023) in women that had a Caesarean section.Conclusions:In this study, women with CHD reported worse mobility and a higher pain level during Tri 3, although the overall health-related quality of life is acceptably high.
To what extent do institutional arrangements shape the excludability of resource systems? Lessons from French farms
Authors: Kassis Grâce 
Published: May 2023

AbstractThe question of the impact of institutional arrangements on the nature of goods is insufficiently addressed in the literature. By the nature of goods, we refer to the economic taxonomy of goods, meaning their privateness is defined according to their degrees of excludability and subtractability. This paper aims to fill this research gap by examining whether institutional arrangements developed for the management of private goods can reduce the degrees of excludability of these goods. To this end, we analyse four collective farmland management projects in the Isère department in France. We adapt the tool of property as a bundle of rights in order to characterize the impact of these projects on the nature of farmland. Our results show that the distribution of land rights, as well as the rules designed to define land rights, influence the degree of excludability of farmland. We discuss the impact of these findings on public policy-making.
Effect of Combined Subsurface Structures and Steps on Hyporheic Exchange
Authors: Tajari M. , Omid M. H. , Dehghani A. A. , Ghameshlou A. N. , Boano F. 
Published: May 2023

AbstractThe deployment of artificial structures in streambeds has been proposed as a way to enhance 21 hyporheic exchange, and numerical models can be used to quantify their effects. In this study, combinations of different structures—that is, boxes, steps and a new type of subsurface structure (L‐shaped structure)—were considered to evaluate their potential applicability on river restoration. Flow‐3D and COMSOL were applied to simulate surface and subsurface flow, respectively. The performance of the structures was evaluated on the basis of hyporheic flow and residence time distributions. For the structure sizes here considered, results showed for steps (single step, combination of two steps) and L‐shaped structures (single L‐shaped structure, combination of two L‐shaped structures) most hyporheic flowpaths return to the stream after 5 and 2.5 hr, respectively. Instead, shorter residence times (<0.25 hr) were found for boxes (single box, combination of two boxes). For combinations of steps and permeable boxes, the values of hyporheic flow per unit width are higher (0.35 and 0.3 m2/hr, respectively) than for the combination of L‐shaped (0.06 m2/hr). As a result, the combinations of steps and boxes are more effective in increasing hyporheic flow. However, when subsurface structures are combined with steps the resulting hyporheic exchange is dominated by the steps. Therefore, the combined use of in‐stream and subsurface structures separately may increase their benefits for hyporheic exchange, but when steps are the other subsurface structures provide minor advantages.
Reconstructing the Unsaturated Flow Equation From Sparse and Noisy Data: Leveraging the Synergy of Group Sparsity and Physics‐Informed Deep Learning
Authors: Song Wenxiang , Shi Liangsheng , Hu Xiaolong , Wang Yanling , Wang Lijun 
Published: May 2023

AbstractData‐driven scientific discovery methods have been developed and applied to discover governing equations from data, involving the attempt to discover the unsaturated flow equation in soils from data. However, an important but unresolved problem is how to reconstruct the unsaturated flow equation from highly noisy and scarce discrete data. In this study, we present a new deep‐learning framework: DeepGS (deep‐learning‐based group sparsity framework), that leverages the synergy of group sparsity and physics‐informed deep learning (PIDL) to reconstruct the latent governing equation for unsaturated flow. In particular, we design a strategy that decomposes the identification of the unsaturated flow equation into two tasks: the determination of the partial differential equation structure and the reconstruction of the nonlinear coefficients. The tasks can be seamlessly handled by group sparse regression and the PIDL approach. Through the training, it realizes the simultaneous reconstruction of soil moisture dynamics and unsaturated flow governing equation. A series of comprehensive numerical experiments are conducted to determine the optimal architecture and test its performance. The results show the efficacy and robustness of DeepGS, which significantly outperform previous methods. We also conclude that accurately reconstructing soil moisture dynamics and spatiotemporal derivatives from noisy and scarce data play a critical role in governing equation discovery. This study further demonstrates the potential of discovering the governing equation for unsaturated flow from data in more complex scenarios, where rich and accurate soil moisture observations are generally intractable to access.
How Does Tropical Cyclone Genesis Frequency Respond to a Changing Climate?
Authors: Zhao Jiuwei , Wang Fang , Zhan Ruifen , Guo Yipeng , Huang Xin , Liu Chao 
Published: May 2023

AbstractGlobal tropical cyclone (TC) genesis frequency (TCGF) has been documented to decrease or increase linearly in a changing climate. However, our numerical experiments show that the global TCGF exhibits a parabolic relation with spatio‐uniform climate changes in sea surface temperature (SST) from −15 K to 5 K relative to the present climate, with the peak in the 5 K‐cooler climate. The parabolic relation is found in all TC basins except the eastern North Pacific where TCGF keeps increasing with the changing climate. TCGF can be expressed as the product of the frequency of TC seeds and the TC survival rate (SR). Further analysis shows that this parabolic structure in the global TCGF depends on TC seeds rather than the TC SR. The TC SR exhibits an increasing trend with the SST increase, while TC seeds show a consistent change with TCGF, which might be linked to the changes in low‐level relative humidity.
Function Model Based on Nonlinear Transient Rheology of Rocks: An Analysis of Decadal GNSS Time Series After the 2011 Tohoku‐oki Earthquake
Authors: Dhar Sambuddha , Muto Jun 
Published: May 2023

AbstractThe postseismic Global Navigation Satellite System (GNSS) time series after the 2011 Tohoku‐oki earthquake is often empirically explained by one or more logarithmic and exponential decay functions. However, a function model with these decay functions struggles to illuminate various deformation mechanisms. Here, we propose a new function model incorporating laboratory‐derived constitutive laws (power‐law flow and velocity‐strengthening friction) utilized in mechanical postseismic models of the last decade. We demonstrated that our function model accurately predicts the decade‐long time series of inland GNSS stations, including coastal areas where significant postseismic uplift continues now. Moreover, it decomposes them into displacements due to viscoelastic relaxation and afterslip, similar to results produced by previous stress‐dependent postseismic models of the 2011 Tohoku‐oki earthquake. This physics‐based function model is an effective tool to ease the process of forecasting long‐term GNSS time series by dividing them into two dominant mechanisms at the plate interface and the surrounding viscoelastic mantle.
The hydrocortisone-responsive urinary metabolome of premature infants
Authors: Torgerson Dara , Guardado Miguel , Steurer Martina , Chapin Cheryl , Hernandez Ryan D. , Ballard Philip L. 
Published: May 2023

Abstract
Background
Extremely premature infants are at risk for circulatory collapse or respiratory failure that are often treated with hydrocortisone (HC); however, there is no information on the metabolic consequences of this therapy.

Methods
Longitudinal urine samples from infants <28 weeks gestation in the Trial of Late Surfactant were analyzed by untargeted UHPLC:MS/MS. Fourteen infants who received a tapering course of HC beginning at 3 mg/kg/day for ≥9 days were compared to 14 matched control infants. A secondary cross-sectional analysis by logistic regression used urines from 314 infants.

Results
Of 1145 urinary metabolites detected, abundance of 219, representing all the major biochemical pathways, changed at p < 0.05 in the HC-treated group with 90% decreasing; 3 cortisol derivatives increased ~2-fold with HC therapy. Only 11% of regulated metabolites remained responsive at the lowest HC dose. Regulated metabolites included two steroids and thiamin that are associated with lung inflammation in infants. HC responsiveness was confirmed in 57% of metabolites by cross-sectional analysis.

Conclusions
HC treatment of premature infants influenced in a dose-dependent manner abundance of 19% of identified urinary metabolites of diverse biochemical systems, primarily reducing concentrations. These findings indicate that exposure to HC reversibly impacts the nutritional status of premature infants.

Impact

Hydrocortisone treatment of premature infants with respiratory failure or circulatory collapse alters levels of a subset of urinary metabolites representing all major biochemical pathways.

This is the first description of the scope, magnitude, timing and reversibility of metabolomic changes in infants in response to hydrocortisone, and it confirms corticosteroid regulation of three biochemicals that are associated with lung inflammatory status.

The findings indicate a dose-dependency of hydrocortisone for metabolomic and anti-inflammatory effects, that prolonged therapy may lower the supply of many nutrients, and that monitoring concentrations of cortisol and inflammation markers may be a useful clinical approach during corticosteroid therapy.
DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship?
Authors: Harju Tekla , Hurme-Niiranen Anri , Suo-Palosaari Maria , Nygaard Nielsen Stine , Hinttala Reetta , Schmiegelow Kjeld , Uusimaa Johanna , Harila Arja , Niinimäki Riitta 
Published: May 2023

AbstractHepatotoxicity is a frequent complication during maintenance therapy of acute lymphoblastic leukemia (ALL) with 6-mercaptopurine and methotrexate. Elevated levels of methylated 6-mercaptopurine metabolites (MeMP) are associated with hepatotoxicity. However, not all mechanisms are known that lead to liver failure in patients with ALL. Variants in the POLG gene, which encodes the catalytic subunit of mitochondrial DNA polymerase gamma (POLG1), have been related to drug-induced hepatotoxicity, for example, by sodium valproate. The association of common POLG variants with hepatotoxicity during maintenance therapy was studied in 34 patients with childhood ALL. Of the screened POLG variants, four different variants were detected in 12 patients. One patient developed severe hepatotoxicity without elevated MeMP levels and harbored a heterozygous POLG p.G517V variant, which was not found in the other patients.
Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity
Authors: Wen Jianbin , Zellner Andreas , Braun Nils Christian , Bajaj Thomas , Gassen Nils Christian , Peitz Michael , Brüstle Oliver 
Published: May 2023

AbstractFIP200 plays important roles in homeostatic processes such as autophagy and signaling pathways such as focal adhesion kinase (FAK) signaling. Furthermore, genetic studies suggest an association of FIP200 mutations with psychiatric disorders. However, its potential connections to psychiatric disorders and specific roles in human neurons are not clear. We set out to establish a human-specific model to study the functional consequences of neuronal FIP200 deficiency. To this end, we generated two independent sets of isogenic human pluripotent stem cell lines with homozygous FIP200KO alleles, which were then used for the derivation of glutamatergic neurons via forced expression of NGN2. FIP200KO neurons exhibited pathological axonal swellings, showed autophagy deficiency, and subsequently elevated p62 protein levels. Moreover, monitoring the electrophysiological activity of neuronal cultures on multi-electrode arrays revealed that FIP200KO resulted in a hyperactive network. This hyperactivity could be abolished by glutamatergic receptor antagonist CNQX, suggesting a strengthened glutamatergic synaptic activation in FIP200KO neurons. Furthermore, cell surface proteomic analysis revealed metabolic dysregulation and abnormal cell adhesion-related processes in FIP200KO neurons. Interestingly, an ULK1/2-specific autophagy inhibitor could recapitulate axonal swellings and hyperactivity in wild-type neurons, whereas inhibition of FAK signaling was able to normalize the hyperactivity of FIP200KO neurons. These results suggest that impaired autophagy and presumably also disinhibition of FAK can contribute to the hyperactivity of FIP200KO neuronal networks, whereas pathological axonal swellings are primarily due to autophagy deficiency. Taken together, our study reveals the consequences of FIP200 deficiency in induced human glutamatergic neurons, which might, in the end, help to understand cellular pathomechanisms contributing to neuropsychiatric conditions.