bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Single Multiomics Transistor for Electronic Detection of SARS‐Cov2 Variants Antigen and Viral RNA Without Amplification
Authors: Ban Deependra K. , Hajian Reza , Winton Alexander J. , Eom Ryan , Gupta Ankit , Kane Alexander A. , Liu Sanchao , Sampath Rangarajan , Farrell Michael L. , Coppock Matthew B. , Goldsmith Brett , Aran Kiana 
Published: April 2023

AbstractThe SARS‐CoV‐2 pandemic caused a public health crisis throughout the world and highlighted the need for rapid and sensitive testing as a countermeasure. A sensitive and specific biosensor platform is developed for the detection of antigen and RNA of SARS‐CoV‐2, and its variant (B1.1.529). The demonstrated biosensor platform combines unique protein catalyzed capture bioreceptors (PCCs) for antigen capture and a chimeric (RNA‐DNA) probe for RNA detection using LwaCas13a collateral cleavage activity atop graphene field effect transistors (gFETs). The reported biosensor is able to differentiate unprocessed 104 pfu m−1 samples of SARS‐CoV‐2 from Influenza and Rhinovirus. The limit of detection (LOD) calculated for SARS‐CoV‐2 antigen is 103 in buffer and 104 PFU mL−1 in 10% saliva, while LOD of ≈65 am calculated for viral RNA isolate without amplification. To provide a high reliability of detection, the role of internal and external factors with respect to gate voltage is further analyzed by Principal Component Analysis (PCA). Based on PCA analysis, the authors are able to classify the samples as pathogen positive or negative (Y > 0: Positive for pathogen, Y < 0: Negative for pathogen). The reported platform can be quickly adapted for multi‐omics and multiplexed diagnosis of continuously evolving biothreats and global pandemics.
Scalable Synthesis of Bulk TiO2 Hybrids Toward Efficient Li‐Storage Performance in “Rocking‐Chair” Type Full‐Cell Assembly With High Voltage LiNi0.5Mn1.5O4 Cathode
Authors: Jyothilakshmi Shaji , Subramanyan Krishnan , Lee Yun‐Sung , Aravindan Vanchiappan 
Published: April 2023

AbstractExploring anode materials with outstanding safety, high capacities, and superior rate performance for lithium‐ion batteries (LIBs) remains a constant objective. A simple and green synthesis method with an excellent electrochemical performance of a TiO2 bronze/anatase hybrid is herein reported as an anode at different temperature conditions (400 °C, 450 °C, and 500 °C) for LIBs. The Li‐ion insertion/extraction properties are studied in a half‐cell assembly (Li/TiO2) and subsequently in a “rocking‐chair” type full‐cell configuration with a high voltage LiNi0.5Mn1.5O4 (LNMO) cathode. In both half and full‐cell assemblies, all three TiO2 hybrids exhibit promising results with an initial discharge capacity of >165 mAh g−1 at a current rate of 0.05 A g−1 along with a capacity retention of >90% after 100 cycles. The initial coulombic efficiency of ≈78% is observed for the full‐cell, LNMO/TiO2‐400 °C, with a maximum energy density of 192.75 Wh kg−1 and good cyclability at room temperature conditions.
Review on III–V Semiconductor Nanowire Array Infrared Photodetectors
Authors: Li Ziyuan , He Zeyu , Xi Chenyang , Zhang Fanlu , Huang Longsibo , Yu Yang , Tan Hark Hoe , Jagadish Chennupati , Fu Lan 
Published: April 2023

AbstractIn recent years, III–V semiconductor nanowires have been widely investigated for infrared photodetector applications due to their direct and suitable bandgap, unique optical and electrical properties, flexibility in device design and to create heterostructures, and/or grow on a foreign substrate such as Si with more effective strain relaxation compared with planar structures. In particular, vertically aligned and ordered nanowire arrays have emerged as a promising photodetector platform, since their geometry‐related light absorption and carrier transport properties can be tailored to achieve high photodetector performance and new functionalities. In this article, the state‐of‐the‐art progress in the development of various types of infrared photodetectors based on III–V semiconductor nanowire arrays is reviewed. The nanowire synthesis/fabrication methods are introduced briefly at first, followed by discussions on the working principle and device performance of various types of nanowire array‐based photodetectors and their emerging applications. Finally, we analyze the challenges and present the perspectives for the development of future low‐cost, large‐scale, high‐performance nanowire array infrared photodetectors for practical applications.
Perennial forages in cold‐humid areas: Adaptation and resilience‐building strategies toward climate change
Authors: Thivierge Marie‐Noëlle , Bélanger Gilles , Jégo Guillaume , Delmotte Sylvestre , Rotz C. Alan , Charbonneau Édith 
Published: April 2023

AbstractIn the continental cold and humid areas of northeastern North America, climate change by mid‐century may increase the yield potential of perennial forage species as a result of increased temperature and atmospheric CO2 concentration, and a longer growing season compared to the 1990−2000 period. More winter thaws and less snow cover along with more summer drought events, however, may reduce winter survival and summer regrowth, thus potentially reducing the persistence of perennial forages over time. Based on nearly two decades of research on the effects of climate change on forages in cold and humid areas of northeastern North America, through field experiments and modeling, we summarize in this review the expected effects of climate change on forage production in terms of yield, nutritive value, and winter survival. We also propose a set of 12 adaptation and resilience‐building strategies for forage systems that can be implemented at the field and farm levels. Research priorities for the future, including the improvement of species, forage management practices, and modeling tools, are also identified. Implementing strategies to alleviate or take advantage of the effects of a changing climate may improve productivity and resilience of well‐adapted forage systems in cold and humid areas.
Dualkatalytisch‐Photochemische H‐Atomtransfer/Kobaltkatalysesequenz Ermöglicht Desaturative Synthese von Phenolen aus Cyclohexanonen
Authors: Caldora Henry P. , Zhang Zhenhua , Tilby Michael J. , Turner Oliver , Leonori Daniele 
Published: April 2023

AbstractPhenole gehören zu den grundlegendsten aromatischen Strukturen, die nicht nur in einer Vielzahl von Naturstoffen zu finden sind, sondern auch routinemäßig für die Herstellung von wertvollen Produkten eingesetzt werden. Die Synthese hochsubstituierter Phenolderivate kann jedoch äußerst komplex sein, wenn das gewünschte Substitutionsmuster nicht durch die dirigierenden Effekte der elektrophilen aromatischen Substitution (SEAr) erreicht werden kann. In diesem Aufsatz präsentieren wir einen alternativen und mechanistisch einzigarten Ansatz zur Phenolsynthese, der saturierte Cyclohexanone als Ausgangsstoffe verwendet. Dieser bei Raumtemperatur ablaufende Prozess wird durch die Nutzung von violettem Licht ermöglicht und kennzeichnet sich durch den Einsatz einer Anthrachinon‐Kobalt‐Dualkatalyse, welcher vier aufeinanderfolgende Wasserstoffatomtransfers ermöglicht.
Role of stemness‐related genes TIMP1, PGF, and SNAI1 in the prognosis of colorectal cancer through single‐cell RNA‐seq
Authors: Shen Yan , Ni Siyi , Li Si , Lv Bin 
Published: April 2023

AbstractBackgroundColorectal cancer (CRC) is a fatal malignant tumor with poor prognosis. Cancer stem cells (CSCs) can cause metastasis, recurrence and drug resistance in CRC. This research aimed to analyze stemness‐related prognostic genes of CRC based on single‐cell RNA‐sequencing (scRNA‐seq) data.MethodsDESeq2 was applied to analyze the differentially expressed genes (DEGs). The mRNA stemness index (mRNAsi) was calculated by one‐class logistic regression (OCLR). The stemness‐related cells were analyzed based on scRNA‐seq dataset GSE166555. Monocle 2 algorithm was used for stemness‐related cells pseudotime trajectory analysis. The stemness‐related prognostic genes were analyzed by clusterProfiler and survival package. The stemness of CRC cells was detected by spheroid formation assay, and the expression of stemness‐related prognostic genes was verified by qRT‐PCR and Western blot.Results7916 DEGs between the CRC and normal tissues were obtained. The mRNAsi of the CRC tissues was shown to be significantly higher than that of the normal tissues. 7 and 8 cell types were annotated respectively in the normal and CRC tissues through analysis of the scRNA‐seq data. Cell–cell interactions (CCIs) in the tumor tissues were revealed to be significantly enhanced than that in the normal tissues. By calculating the ‘stemness score’, CSCs, epithelial cells (EPCs) and cancer‐associated fibroblasts (CAFs) were defined as stemness‐related cells. Through pseudotime trajectory analysis, 2111 genes were identified as state 2‐specific genes. Then, 41 genes were obtained by taking intersection of the up‐regulated genes with state 2‐specific genes and marker genes of CSCs, EPCs and CAFs. The univariate COX regression analysis revealed 5 stemness‐related prognostic genes (TIMP1, PGF, FSTL3, SNAI1 and FOXC1). Kaplan–Meier curve analysis indicated that the higher the expression of 5 genes, the lower the survival rate. In vitro cell experiment confirmed that the expression of TIMP1, PGF and SNAI1 was consistent with that revealed by bioinformatics analysis.ConclusionsTIMP1, PGF and SNAI1 were identified as stemness‐related prognostic genes of CRC, and possibly potential therapeutic targets for CRC.
Single‐cell characteristics and malignancy regulation of alpha‐fetoprotein‐producing gastric cancer
Authors: Mei Yanxia , Li Ming , Wen Jihang , Kong Xiangxing , Li Jun 
Published: April 2023

AbstractObjectiveTo characterize alpha‐fetoprotein (AFP)‐producing gastric cancer (AFPGC) at the single‐cell level and to identify regulatory factors for AFP expression and malignancy.MethodsScRNA‐seq was performed on two tumors collected from patients with AFPGC. InferCNV and sub‐clustering were applied to identify typical AFPGC cells, followed by AddModuleScore, pathway enrichment, Pseudo‐time, and Scenic analyses. Data from a gastric cancer (GC) cohort were collected for conjoint analysis. The analytical results were verified by cell experiments and immunohistochemistry.ResultsAFPGC cells are similar to hepatocytes in transcriptome and transcriptional regulation, with kinetic malignancy‐related pathways, compared to the common malignant epithelium. In addition, compared to common GC cells, malignancy‐related pathways, such as epithelial‐mesenchymal transition (EMT) and angiogenesis, were upregulated in AFPGC. Mechanistically, Dickkopf‐1 (DKK1) was found to be associated with AFP expression and malignant phenotype upon combining our scRNA‐seq data with a public database, which was further verified by a series of in vitro experiments and immunohistochemistry.ConclusionWe demonstrated the single‐cell characteristics of AFPGC and that DKK1 facilitates AFP expression and malignancy.
A five arm natural history study of nasal vestibulitis
Authors: Cathcart‐Rake Elizabeth J. , Zahrieh David , Smith Deanne , Young Susan , McCue Shaylene , O'Connor Amanda , Thomé Stephan , Lacouture Mario , Register Terra , Piens Jill , Friday Bret B. , Loprinzi Charles L. 
Published: April 2023

AbstractIntroductionNasal symptoms are frequently reported by patients undergoing chemotherapy.MethodsEligible patients planning to receive paclitaxel, docetaxel, nab‐paclitaxel, bevacizumab without a concomitant taxane, or “other” (non‐taxane, non‐bevacizumab) chemotherapy regimens were invited to participate in this prospective study. Patients reported nasal symptoms prior to each dose of chemotherapy.ResultsThe percentage of patients (95% CI) who reported nasal symptoms was the same for patients who received bevacizumab or nab‐paclitaxel, 82.6% (61.2%, 95.1%). There were no significant differences among the proportions of patients experiencing nasal symptoms within the paclitaxel, nab‐paclitaxel, and bevacizumab cohorts. Patients in the nab‐paclitaxel cohort were more likely to experience symptoms than those in the non‐taxane non‐bevacizumab cohort or docetaxel cohort (p = 0.001, p = 0.001). Patients in the bevacizumab cohort were more likely to experience nasal symptoms than those in the non‐taxane non‐bevacizumab cohort (p = 0.03).ConclusionNasal vestibulitis symptoms are common in patients receiving chemotherapy, especially those receiving paclitaxel, docetaxel, and bevacizumab. Further investigations into treatments of this symptom complex are warranted.
Inequalities in survival and care across social determinants of health in a cohort of advanced lung cancer patients in Quebec (Canada): A high‐resolution population‐level analysis
Authors: Qureshi Samia , Boily Gino , Boulanger Jim , Pagé Élisabeth , Strumpf Erin 
Published: April 2023

AbstractBackgroundAdvanced lung cancer patients exposed to breakthrough therapies like EGFR tyrosine kinase inhibitors (EGFR‐TKI) may experience social inequalities in survival, partly from differences in care. This study examined survival by neighborhood‐level socioeconomic and sociodemographic status, and geographical location of advanced lung cancer patients who received gefitinib, an EGFR‐TKI, as first‐line palliative treatment. Differences in the use and delay of EGFR‐TKI treatment were also examined.MethodsLung cancer patients receiving gefitinib from 2001 to 2019 were identified from Quebec's health administrative databases. Accounting for age and sex, estimates were obtained for the median survival time from treatment to death, the probability of receiving osimertinib as a second EGFR‐TKI, and the median time from biopsy to receiving first‐line gefitinib.ResultsAmong 457 patients who received first‐line treatment with gefitinib, those living in the most materially deprived areas had the shortest median survival time (ratio, high vs. low deprivation: 0.69; 95% CI: 0.47–1.04). The probability of receiving osimertinib as a second EGFR‐TKI was highest for patients from immigrant‐dense areas (ratio, high vs. lowdensity: 1.95; 95% CI: 1.26–3.36) or from Montreal (ratio, other urban areas vs. Montreal: 0.39; 95% CI: 0.16–0.71). The median wait time for gefitinib was 1.27 times longer in regions with health centers peripheral to large centers in Quebec or Montreal in comparison to regions with university‐affiliated centers (95% CI: 1.09–1.54; n = 353).ConclusionThis study shows that real‐world variations in survival and treatment exist among advanced lung cancer patients in the era of breakthrough therapies and that future research on inequalities should also focus on this population.
A Novel Near‐IR Absorbing Ruthenium(II) Complex as Photosensitizer for Photodynamic Therapy and its Cetuximab Bioconjugates
Authors: Martínez‐Alonso Marta , Gandioso Albert , Thibaudeau Chloé , Qin Xue , Arnoux Philippe , Demeubayeva Nurikamal , Guérineau Vincent , Frochot Céline , Jung Alain C. , Gaiddon Christian , Gasser Gilles 
Published: April 2023

AbstractA novel Ru(II) cyclometalated photosensitizer (PS), Ru‐NH2, for photodynamic therapy (PDT) of formula [Ru(appy)(bphen)2]PF6 (where appy=4‐amino‐2‐phenylpyridine and bphen=bathophenanthroline) and its cetuximab (CTX) bioconjugates, Ru‐Mal‐CTX and Ru‐BAA‐CTX (where Mal=maleimide and BAA=benzoylacrylic acid) were synthesised and characterised. The photophysical properties of Ru‐NH2 revealed absorption maxima around 580 nm with an absorption up to 725 nm. The generation of singlet oxygen (1O2) upon light irradiation was confirmed with a 1O2 quantum yield of 0.19 in acetonitrile. Preliminary in vitro experiments revealed the Ru‐NH2 was nontoxic in the dark in CT‐26 and SQ20B cell lines but showed outstanding phototoxicity when irradiated, reaching interesting phototoxicity indexes (PI) >370 at 670 nm, and >150 at 740 nm for CT‐26 cells and >50 with NIR light in SQ20B cells. The antibody CTX was successfully attached to the complexes in view of the selective delivery of the PS to cancer cells. Up to four ruthenium fragments were anchored to the antibody (Ab), as confirmed by MALDI‐TOF mass spectrometry. Nonetheless, the bioconjugates were not as photoactive as the Ru‐NH2 complex.
Predictors of hemodynamic response to mitral transcatheter edge‐to‐edge repair
Authors: Samimi Sahar , Chavez Ponce Alejandra , Alarouri Hasan S. , Shaer Ahmed El , Eleid Mackram F. , Guerrero Mayra E. , Rihal Charanjit S. , Alkhouli Mohamad 
Published: April 2023

AbstractBackgroundImprovement in left atrial pressure (LAP) during transcatheter edge‐to‐edge repair (TEER) is associated with improved outcomes. We sought to investigate the predictors of optimal hemodynamic response to TEER.MethodsWe identified patients who underwent TEER at Mayo Clinic between May 2014 and February 2022. Patients with missing LAP data, an aborted procedure, and those undergoing a concomitant tricuspid TEER were excluded. We performed a logistic regression analysis to identify predictors of optimal hemodynamic response to TEER (defined as LAP ≤ 15 mmHg).ResultsA total of 473 patients were included (Mean age 78.5 ± 9.4 years, 67.2% males). Overall, 195 (41.2%) achieved an optimal hemodynamic response after TEER. Patients who did not achieve an optimal response had higher baseline LAP (20.0 [17–25] vs. 15.0 [12–18] mmHg, p < 0.001), higher prevalence of AF (68.3% vs. 55.9%, p = 0.006), functional MR (47.5% vs. 35.9%, p = 0.009), annular calcification (41% vs. 29.2%, p = 0.02), lower left ventricular EF (55% vs. 58%, p = 0.02), and more frequent postprocedural severe MR (11.9% vs. 5.1%, p = 0.02) and elevated mitral gradient >5 mmHg (30.6% vs. 14.4%, p < 0.001). In the multivariate logistic regression analysis, AF (OR = 0.58; 95% CI = 0.35–0.96; p = 0.03), baseline LAP (OR = 0.80; 95% CI = 0.75–0.84; p < 0.001) and postprocedural mitral gradient <5 mmHg (OR = 0.35; 95% CI = 0.19–0.65; p < 0.001), were independent predictors of achieving an optimal hemodynamic response. In the multivariate model, residual MR was not independently associated with optimal hemodynamic response.ConclusionsOptimal hemodynamic response is achieved in 4 in 10 patients undergoing TEER. AF, higher baseline LAP, and higher postprocedural mitral gradient were negative predictors of optimal hemodynamic response after TEER.
Estimation of the chain propagation rate constants of propylene polymerization and ethylene‐1‐hexene copolymerization catalyzed with MgCl2‐supported Ziegler–Natta catalysts
Authors: Zhong Wentao , Xu Tao , Shen Xianrong , Fu Zhisheng , Cai Xiaoxia , Liu Haitao , Wang Qi , Fan Zhiqiang 
Published: April 2023

AbstractIn olefin polymerization with MgCl2‐supported Ziegler–Natta (Z–N) catalysts, the apparent propagation rate constant (kp)a calculated by Rp = (kp)a [C*] CMe (CMe is equilibrium monomer concentration in the reaction system) declines with reaction time for gradually developed monomer diffusion limitation in the polymer/catalyst particles. In this work, a simplified multi‐grain particle model was proposed to build correlation between (kp)a and other kinetic parameters that can be determined experimentally. Rate profiles of propylene polymerization and ethylene‐1‐hexene copolymerization by three MgCl2‐supported Z–N catalysts were determined, and the (kp)a data was calculated using [C*] determined by quench‐labelling the propagation chains with acyl chloride. Decline of (kp)a in each polymerization process was precisely fitted by the linear correlation between lg(kp)a and [(ρcatmp)/(ρpmcat) + 1]1/3 developed on the particle model. Real propagation rate constant (kp) was estimated by extrapolating the fitting line to the starting point of polymerization, where no concentration gradient exists. According to the particle model, the slope of the lg(kp)a versus [(ρcatmp)/(ρpmcat) + 1]1/3 line (lgd) represents the degree of monomer diffusion limitation. Variations of parameter d found in the studied reaction systems can be reasonably explained based on the knowledge of olefin diffusion in the polymer phase.
Effects of an educational physical activity intervention in young women with newly diagnosed breast cancer: Findings from the Young and Strong Study
Authors: Ligibel Jennifer A. , Zheng Yue , Barry William T. , Sella Tal , Ruddy Kathryn J. , Greaney Mary L. , Rosenberg Shoshana M. , Emmons Karen M. , Partridge Ann H. 
Published: April 2023

AbstractBackgroundObesity and inactivity are poor prognostic factors in breast cancer, but less is known regarding physical activity (PA) and weight patterns in young breast cancer survivors.MethodsThe Young and Strong Study was a cluster‐randomized trial evaluating education and support interventions for young women (age <45 years) with newly diagnosed breast cancer. Sites were randomized 1:1 to a Young Women's Intervention (YWI) or a contact‐time control physical activity intervention (PAI). Changes in PA and weight were compared between groups using general estimating equations to evaluate clustered binary and Gaussian data.ResultsA total of 467 patients enrolled between July 2012 and December 2013 across 54 sites. Median age at diagnosis was 40 years (range, 22–45). At baseline, median body mass index (BMI) was 25.4 kg/m2 (range, 16.1–61.1), and participants reported a median of 0 minutes (range, 0–2190) of moderate/vigorous PA/week. PA increased significantly over time in both groups (p < .001), with no difference between groups at any time point. BMI increased modestly but significantly (p < .001) over time in both groups. Provider attention to PA was observed in 74% of participants on PAI and 61% on YWI (p = .145) and correlated with PA at 12 months (median 100 min/week of PA in participants with provider attention to PA vs. 60 min/week in those without, p = .016).ConclusionsIn a cohort of young women with breast cancer, rates of obesity and inactivity were high. PA and BMI increased over time and were not impacted by an educational PA intervention. Findings provide important information for developing lifestyle interventions for young breast cancer survivors.
Water resource management and financial performance in high water‐sensitive corporates
Authors: Ji Yuguang , Ji Maoli , Yang Gang , Dong Shulan 
Published: April 2023

AbstractWater is a valuable resource in the world, and water resource management is an important aspect of corporate social responsibility. Does water resource management affect corporate financial performance? What is the influencing path? To find the potential relationship and influencing mechanism between water resource management and corporate financial performance, based on configuration thinking, we selected 259 A‐share listed manufacturing corporates from 2015 to 2021 as research samples, using fuzzy set qualitative comparative analysis method (fsQCA) to explore the configuration and influencing path of water resource management affecting financial performance. Then we analyzed it with the configuration that CSR score (excluding “environmental responsibility”) affects financial performance. Our results show that: (1) poor water management and low CSR score will lead to bad corporate financial performance, but the former's severity of negative impact on corporate financial performance is more than that of the latter. Specific configurations indicate that companies with little water‐related concrete actions implemented and technology innovation will severely hurt the financial performance. (2) Good water resources management cannot directly achieve high financial performance while high CSR score can make it, indicating that water resource management is a necessary but not sufficient condition for high corporate financial performance. Our research has unmasked the "black box" influencing mechanism of water resource management on corporate financial performance to some extent, which makes the configuration relationship between water resource management and financial performance clearer, therefore owns certain theoretical significance and practical value in the field of CSR and environmental management.