bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening and validation of potential markers associated with uterine corpus endometrial carcinoma and polycystic ovary syndrome based on bioinformatics methods
Authors: Wu Ruishan , Wu Cailin , Zhu Bingming , Li Jin , Zhao Wenzhong 
Published: June 2023

Background: Endometrial cancer (UCEC) is a commonly occurring tumor in females, and polycystic ovary syndrome (PCOS) is closely related to UCEC, but the molecular mechanisms remain unclear. This article aims to explore potential molecular mechanisms in UCEC and PCOS, as well as identify prognostic genes for UCEC.Methods: Bioinformatics methods were employed to screen for DEGs in UCEC and PCOS. The shared DEGs were analyzed by constructing a protein-protein interaction (PPI) network using the String database and Cytoscape software. The enrichment analysis was performed using Metascape. The shared DEGs associated with the prognosis of UCEC were identified through univariate and lasso Cox regression methods. A multivariate Cox regression model was constructed and internally validated. The expression and test efficiency of the key prognostic genes were verified using external datasets for UCEC and PCOS. Furthermore, the Gepia database was utilized to analyze the expression of key prognostic genes and their correlation with the disease-free survival (RFS) of UCEC. Tumor mutation burden (TMB), immune infiltration, and the correlation of immune cells were assessed for the prognostic genes of UCEC.Results: There were 151 shared DEGs identified between UCEC and PCOS through bioinformatics screening. These shared DEGs were primarily enriched in leukocyte activation. Following model construction and verification, nine genes were determined to be prognostic for UCEC from the shared DEGs. Among them, TSPYL5, KCNJ15, RTN1, HMOX1, DCAF12L1, VNN2, and ANXA1 were confirmed as prognostic genes in UCEC through external validation. Additionally, RTN1 was identified as a key gene in both UCEC and PCOS. Gepia analysis revealed that higher expression of RTN1 was associated with RFS in UCEC. Immune infiltration analysis of the shared DEGs demonstrated significant differences in the expression of various immune cells between UCEC high and low TMB groups. The seven key prognostic genes in UCEC exhibited regulatory relationships with immune cells.Conclusion: This study identified TSPYL5, KCNJ15, RTN1, HMOX1, DCAF12L1, VNN2, and ANXA1 as the key prognostic DEGs of UCEC. These genes are associated with UCEC survival, TMB, immune cell infiltration, and immune cell regulation. Among them, RTN1 may serve as a potential biomarker for both UCEC and PCOS.
Sex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes
Authors: Zakiniaeiz Yasmin , Gueorguieva Ralitza , Peltier MacKenzie R. , Verplaetse Terril L. , Roberts Walter , McKee Sherry A. , Cosgrove Kelly P. 
Published: June 2023

IntroductionSex differences exist in tobacco smoking. Women have greater difficulty quitting smoking than men. Tobacco smoking is driven by the reinforcing effects of nicotine, the primary addictive component in cigarettes. Nicotine binds to nicotinic acetylcholine receptors, facilitating dopamine release in striatal and cortical brain regions. Dysregulated dopamine D2/3 receptor signaling in the dorsolateral prefrontal cortex (dlPFC) is associated with cognitive deficits such as impairments in attention, learning, and inhibitory control that impede quit attempts. Sex steroid hormones, such as estradiol and progesterone, influence drug-taking behaviors, through dopaminergic actions, suggesting that their influence may explain sex differences in tobacco smoking. The goal of this study was to relate dlPFC dopamine metrics to sex steroid hormone levels in people who smoke and healthy controls.MethodsTwenty-four (12 women) people who smoke cigarettes and 25 sex- and age-matched controls participated in two same-day [11C]FLB457 positron emission tomography scans, one before and one after amphetamine administration. D2R availability (BPND) at baseline and after amphetamine administration was calculated. On the same day, plasma samples were collected for the analysis of sex steroid hormone levels: estradiol, progesterone, and free testosterone.ResultsWomen who smoke had trending lower levels of estradiol than their sex-matched counterparts. Men who smoke had higher levels of estradiol and trending higher levels of free testosterone than their sex-matched counterparts. Among women only, lower estradiol levels were significantly associated with lower pre-amphetamine dlPFC BPND.Discussion/conclusionThis study demonstrated that lower estradiol levels are associated with lower dlPFC D2R availability in women which may underlie difficulty resisting smoking.
Sex-specific reference values for total, central, and peripheral latency of motor evoked potentials from a large cohort
Authors: Cantone Mariagiovanna , Lanza Giuseppe , Fisicaro Francesco , Bella Rita , Ferri Raffaele , Pennisi Giovanni , Waterstraat Gunnar , Pennisi Manuela 
Published: June 2023

BackgroundDifferentiating between physiologic and altered motor evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) is crucial in clinical practice. Some physical characteristics, such as height and age, introduce sources of variability unrelated to neural dysfunction. We provided new age- and height-adjusted normal values for cortical latency, central motor conduction time (CMCT), and peripheral motor conduction time (PMCT) from a large cohort of healthy subjects.MethodsPreviously reported data from 587 participants were re-analyzed. Nervous system disorders were ruled out by clinical examination and magnetic resonance imaging. MEP latency was determined as stimulus-to-response latency through stimulation with a circular coil over the “hot spot” of the First Dorsal Interosseous and Tibialis Anterior muscles, during mild tonic contraction. CMCT was estimated as the difference between MEP cortical latency and PMCT by radicular magnetic stimulation. Additionally, right-to-left differences were calculated. For each parameter, multiple linear regression models of increasing complexity were fitted using height, age, and sex as regressors.ResultsMotor evoked potential cortical latency, PMCT, and CMCT were shown to be age- and height-dependent, although age had only a small effect on CMCT. Relying on Bayesian information criterion for model selection, MEP cortical latency and PMCT were explained best by linear models indicating a positive correlation with both height and age. Also, CMCT to lower limbs positively correlated with height and age. CMCT to upper limbs positively correlated to height, but slightly inversely correlated to age, as supported by non-parametric bootstrap analysis. Males had longer cortical latencies and CMCT to lower limbs, as well as longer PMCT and cortical latencies to upper limbs, even when accounting for differences in body height. Right-to-left-differences were independent of height, age, and sex. Based on the selected regression models, sex-specific reference values were obtained for all TMS-related latencies and inter-side differences, with adjustments for height and age, where warranted.ConclusionA significant relationship was observed between height and age and all MEP latency values, in both upper and lower limbs. These set of reference values facilitate the evaluation of MEPs in clinical studies and research settings. Unlike previous reports, we also highlighted the contribution of sex.
Effect of transdermal drug delivery therapy on anxiety symptoms in schizophrenic patients
Authors: Zhu Cuifang , Wang Xin-Yue , Zhao Jing , Long Bin , Xiao Xudong , Pan Ling-Yi , Yuan Ti-Fei , Chen Jian-Hua 
Published: June 2023

ObjectiveTo evaluate the efficacy and safety of transdermal drug delivery therapy for schizophrenia with anxiety symptoms.MethodsA total of 80 schizophrenic patients (34 males and 56 females) with comorbid anxiety disorders were randomly assigned to the treatment group (n = 40) and the control group (n = 40) with 6 weeks of follow-up. The patients in the treatment group received the standard antipsychotic drug treatment along with transdermal drug delivery therapy. The evaluation of the patients included the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD-17), and treatment emergent symptom scale (TESS) at baseline, 3 weeks, and 6 weeks after transdermal drug delivery therapy. The Positive and Negative Symptom Scale (PANSS) was assessed at baseline and after 6 weeks of treatment.ResultsAfter 3 and 6 weeks of treatment, the HAMA scale scores in the treatment group were lower than those in the control group (p &lt; 0.001). However, there were no significant differences in the HAMD-17 scale scores, PANSS total scores, and subscale scores between the two groups (p &gt; 0.05). Additionally, no significant differences in adverse effects were observed between the two groups during the intervention period (p &gt; 0.05). After 6 weeks of penetration therapy, there was a low negative correlation between total disease duration and the change in HAMA scale score (pretreatment-posttreatment) in the treatment group.ConclusionCombined traditional Chinese medicine directed penetration therapy can improve the anxiety symptoms of patients with schizophrenia and has a safe profile.
Indocyanine green angiography for lower incidence of anastomotic leakage after transanal total mesorectal excision: a propensity score-matched cohort study
Authors: Chen Hengkai , Ye Linfang , Huang Changyu , Shi Yingjun , Lin Fangzhou , Ye Honghao , Huang Yongjian 
Published: June 2023

BackgroundAnastomotic leakage (AL) is the most serious complication that can arise during colorectal surgery. Indocyanine green (ICG) angiography offers an intraoperative assessment of colonic vascular perfusion in real time. We aimed to assess ICG’s effects on the AL rate in patients who have undergone transanal total mesorectal excision (TaTME) for rectal cancer.MethodsThis retrospective cohort study was conducted at our center from October 2018 to March 2022 to analyze the clinical data of patients with rectal cancer who have undergone TaTME after propensity score matching (PSM). The primary outcome was the proximal colonic transection line modification and clinical AL rate.ResultsA total of 143 patients in the non-ICG group and 143 patients in the ICG group were included after PSM. The proximal colonic transection line of seven patients in the non-ICG group was modified, while 18 were in the ICG group (4.9% vs. 12.5%, p = 0.023). Twenty-three patients (16.1%) in the non-ICG group and five patients (3.5%) in the ICG group were diagnosed with AL (p &lt; 0.001). The ICG group had a less hospital readmission rate than the non-ICG group (0.7% vs. 7.7%, p = 0.003). The between-group differences in basic line and other outcomes were not significant.ConclusionsICG angiography is a safe and feasible method to help surgeons identify potentially poor colonic vascular perfusion and modify the proximal colonic transection line, resulting in a significant reduction in AL and hospital readmission rates.
Acupuncture for postoperative gastrointestinal dysfunction in cancer: a systematic review and meta-analysis
Authors: Lin Dezhi , Ou Yangxu , Li Longlong , Wu Kexin , Zhang Qiang , Yan Jiayin , Kuang Kunlin , Peng Dezhong 
Published: June 2023

BackgroundPostoperative gastrointestinal dysfunction (PGD) in cancer is the commonest and most severe postoperative complication in patients with cancer. Acupuncture has been widely used for PGD in cancer. This study aimed to evaluate the efficacy and safety of acupuncture for PGD in cancer.MethodsWe comprehensively searched eight randomised controlled trials (RCTs) of acupuncture for PGD in cancer published until November 2022. Time to first flatus (TFF) and time to first defecation (TFD) were the primary outcomes, and time to bowel sound recovery (TBSR) and the length of hospital stay (LOS) were the secondary outcomes. The Cochrane Collaboration Risk of Bias Tool was used to assess the quality of the RCTs, and the Grading of Recommendations Assessment, Development, and Evaluations (GRADE) system was used to evaluate the certainty of the evidence. The meta-analysis was performed using RevMan 5.4, and a publication bias test was performed using Stata 15.1.ResultsSixteen RCTs involving 877 participants were included in this study. The meta-analysis indicated that acupuncture could effectively reduce the TFF, TFD, and TBSR compared with routine treatment (RT), sham acupuncture, and enhanced recovery after surgery (ERAS). However, acupuncture did not shorten the LOS compared with RT and ERAS. The subgroup analysis revealed that acupuncture could significantly reduce the TFF and TFD. Acupuncture effectively reduced the TFF and TFD in all cancer types included in this review. Besides, local acupoints in combination with distal acupoints could reduce the TFF and TFD, and distal–proximal acupoints could significantly reduce the TFD. No trial reported adverse events of acupuncture.ConclusionsAcupuncture is an effective and relatively safe modality for treating PGD in cancer. We anticipate that there will be more high-quality RCTs involving more acupuncture techniques and cancer types, focusing on combining acupoints for PGD in cancer, further determining the effectiveness and safety of acupuncture for PGD in patients with cancer outside China.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42022371219.
Predictors of health-related quality of life in outpatients with coronary heart disease
Authors: Frøjd Lars Aastebøl , Munkhaugen John , Papageorgiou Costas , Sverre Elise , Moum Torbjørn , Dammen Toril 
Published: June 2023

IntroductionHealth-related quality of life (HRQoL) is an important treatment target in patients with coronary heart disease (CHD) and is associated with poor outcomes. Therefore, it is of clinical importance to identify the key determinants of HRQoL among these patients. There is, however, limited knowledge of how a comprehensive set of psychosocial factors influence HRQoL. We aimed to determine the relative associations of clinical and psychosocial factors with mental and physical components of HRQoL in a sample of CHD outpatients.MethodsThis cross-sectional study included 1,042 patients 2–36 (mean 16) months after a CHD event recruited from two general Norwegian hospitals with a combined catchment area making up 7% of the Norwegian population, representative with regards to demographic and clinical factors. We collected data on HRQoL, demographics, comorbidities, coronary risk factors, and psychosocial factors. HRQoL was assessed using the Short Form 12 (SF12), which comprises a Mental Component Scale (MCS), and the Physical Component Scale (PCS). Crude and multi-adjusted linear regression analyses were used to investigate the association between covariates and MCS and PCS.ResultsMean age was 61 [standard deviation (SD) 10] years, 20% were females, 18% had type D personality, 20% significant depression symptoms, 14% significant symptoms of anxiety whereas 45% reported insomnia. The presence of type D personality (β: −0.19), significant symptoms of depression (β: −0.15), and the presence of insomnia (β: −0.13) were negatively associated with MCS, but not PCS in multi-adjusted analyses. The presence of chronic kidney disease (β: −0.11) was associated with reduced MCS, whereas the presence of chronic obstructive pulmonary disease (β: −0.08) and low physical activity (β: −0.14) were negatively associated with PCS. Younger age was associated with lower MCS, whereas older age was associated with lower PCS.DiscussionWe conclude that Type D personality, depressive symptoms, insomnia, and chronic kidney disease were the strongest determinants of the mental component of HRQoL. Assessing and managing these psychological factors among CHD outpatients may improve their mental HRQoL.
Understanding the associations between personality traits and mental health in people with epilepsy and healthy controls
Authors: Kang Weixi 
Published: June 2023

ObjectivesThe aim of the current study was to test how epilepsy could moderate the associations between Big Five personality traits and mental health.MethodsThis cross-sectional study analyzed data from Understanding Society: UK Household Longitudinal (UKHLS), which relies on a complex multi-stage stratified sampling design. Personality traits were measured by the Big Five inventory whereas mental health where measured by the GHQ-12. A hierarchical regression and two multiple regressions were performed on 334 people with epilepsy with a mean age of 45.14 ± 15.88 years old (41.32% males) and 26,484 healthy controls (42.5% males) with a mean age of 48.71 ± 17.04 years old.ResultsNeuroticism was positively related to worse mental health in both people with epilepsy and healthy controls with a stronger relationship in people with epilepsy, but Conscientiousness was negatively related to worse mental health in both people with epilepsy and healthy controls. Moreover, Openness and Extraversion were negatively related to worse mental health in healthy controls but not in people with epilepsy.ConclusionPersonality traits are closely related to mental health in both people with epilepsy and healthy controls. Clinicians should use findings from this study to detect people with epilepsy who may be at high risk of poor mental health based on their personality traits.
Using virtual reality to assess gesture performance deficits in schizophrenia patients
Authors: Pavlidou Anastasia , Gorisse Geoffrey , Banakou Domna , Walther Sebastian 
Published: June 2023

IntroductionGesture performance deficits are prevalent in schizophrenia patients and are strongly associated with poor social communication skills and community functioning, affecting their overall quality of life. Currently, video-recording technology is widely used in clinical settings to assess gesture production deficits in schizophrenia patients. Nevertheless, the subjective evaluation of video-recordings can encumber task assessment. The present study will aim to use virtual reality to examine its potential use as an alternative tool to objectively measure gesture performance accuracy in schizophrenia patients and healthy controls.MethodsGesture performance in the virtual reality setting will be based on the well-established Test of Upper Limb Apraxia. Participants will be immersed in a virtual environment where they will experience themselves being embodied in a collocated virtual body seen from a first-person perspective. Motion trackers will be placed on participants' hands and elbows to track upper body movements in real-time, and to record gesture movement for later analysis. Participants will see a virtual agent sitting across from them, with a virtual table in between. The agent will perform various types of gestures and the participants' task will be to imitate those gestures as accurately as possible. Measurements from the tracking devices will be stored and analyzed to address gesture performance accuracy across groups.DiscussionThis study aims to provide objective measurements of gesture performance accuracy in schizophrenia patients. If successful, the results will provide new knowledge to the gesture literature and offer the potential for novel therapeutic interventions using virtual reality technologies. Such interventions can improve gesturing and thus advance social communication skills in schizophrenia patients.
Umbrella systematic review finds limited evidence that school absence explains the association between chronic health conditions and lower academic attainment
Authors: Jay Matthew A. , Sanders-Ellis David , Blackburn Ruth , Deighton Jessica , Gilbert Ruth 
Published: June 2023

IntroductionAbsence from school is more frequent for children with chronic health conditions (CHCs) than their peers and may be one reason why average academic attainment scores are lower among children with CHCs.MethodsWe determined whether school absence explains the association between CHCs and academic attainment through a systematic review of systematic reviews of comparative studies involving children with or without CHCs and academic attainment. We extracted results from any studies that tested whether school absence mediated the association between CHCs and academic attainment.ResultsWe identified 27 systematic reviews which included 441 unique studies of 7, 549, 267 children from 47 jurisdictions. Reviews either covered CHCs generally or were condition-specific (e.g., chronic pain, depression, or asthma). Whereas reviews found an association between a range of CHCs (CHCs generally, cystic fibrosis, hemophilia A, end-stage renal disease (pre-transplant), end-stage kidney disease (pre-transplant), spina bifida, congenital heart disease, orofacial clefts, mental disorders, depression, and chronic pain) and academic attainment, and though it was widely hypothesized that absence was a mediator in these associations, only 7 of 441 studies tested this, and all findings show no evidence of absence mediation.ConclusionCHCs are associated with lower academic attainment, but we found limited evidence of whether school absence mediates this association. Policies that focus solely on reducing school absence, without adequate additional support, are unlikely to benefit children with CHCs.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=285031, identifier: CRD42021285031.
Voluntary blood donation knowledge, attitude, and practice among adult populations of Hosanna Town, South Ethiopia: a community-based cross-sectional study
Authors: Mussema Abdulhakim , Bawore Solomon Gebre , Abebaw Tewodros , Tadese Wegayehu , Belayineh Melsew , Yirga Abel , Mohammed Tofik , Seid Abdurezak Mohammed 
Published: June 2023

IntroductionEven though blood donation has increased in the past decades, it remains a challenge worldwide. An adequate blood supply can only be assured through voluntary blood donation. There is inadequate information on the level of blood donation practice in the current study area. This study aimed to assess the knowledge, attitude, practice, and associated factors toward voluntary blood donation among Hosanna town adult populations.MethodsA cross-sectional study was conducted from 1 May 2022 to 30 June 2022, on a total of 422 adult populations of Hosanna town. A simple random sampling technique was used to select the study subjects. Data were collected by face-to-face interviews using a structured pre-tested questionnaire. The levels of knowledge, attitude, and practice of participants toward voluntary blood donation were measured using a set of questions. Data were analyzed using SPSS version 25. Chi-square and odds ratios were calculated, and the results were presented with words and tables.ResultsIn this study, a total of 422 participants enrolled with a response rate of 96.6%. Of the total respondents, 204 (48.3%), 209 (49.5%), and 123 (29.15%) study participants had good knowledge, favorable attitude, and experience of blood donation, respectively. Participants' sex being male and having favorable attitudes were found to have significant associations with blood donation practice. Furthermore, it was found that male participants were more than two and a half times more likely to donate blood than female participants (AOR: 2.53; 95% CI: 1.54, 4.15). Those who had favorable attitudes were found more than three and a half times more likely to donate blood than those having unfavorable attitudes (AOR: 3.54; 95% CI: 1.32, 9.46)Conclusion and recommendationsA large proportion of adult populations had poor knowledge, unfavorable attitudes, and low practice toward voluntary blood donation. Therefore, local and national blood banks and transfusion agencies should design strategies that can be implemented to improve the knowledge or attitude of the adult population and motivate the population to donate blood voluntarily.