bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel and Predictive QSAR Model and Molecular Docking: New Natural
Sulfonamides of Potential Concern against SARS-Cov-2
Authors: Moussa Nathalie , Mando Huda 
Published: July 2023

Background:
Since the outbreak of the COVID-19 pandemic in 2019, the world has been racing to develop effective drugs for treating this deadly disease. Although there are now some vac-cines that have somewhat alleviated global panic, the lack of approved drugs remains a persistent challenge. Consequently, there is a pressing need to discover new therapeutic molecules.

Methods:
In this study, we explore the application of a quantitative structure−activity relationship (QSAR) model to predict the efficacy of 28 cyclic sulfonamide derivatives against SARS-CoV-2. The model was developed using multiple linear regression, and six molecular descriptors were identified as the most significant factors in determining the inhibitory activity. This proposed QSAR model holds the potential for aiding the virtual screening and drug design process in the development of new and more effective SARS-CoV-2 inhibitors. The model was also applied to seven natural products primary sulfonamides and sulfamates, demonstrating promising activity

Results:
The study results indicated that the atom count, as represented by the descriptor nCl, had the most significant impact on the inhibitory activity against SARS-CoV-2. The proposed model was val-idated using various statistical parameters, confirming its validity, robustness, and predictiveness, with a high correlation coefficient (R2) of 0.77 for the training group and 0.95 for the test group. Further-more, we predicted the activity of seven natural compounds, and among them, Dealanylascamycin exhibited the highest predicted activity. Subsequently, Dealanylascamycin was docked to SARS-CoV-2 and the results of the docking study further strengthened its potential as a promising candidate against COVID-19, suggesting that it should be considered for further optimization and validation.

Conclusion:
Our findings demonstrate promising predicted inhibitory activity against SARS-CoV-2 for seven natural products, primary sulfonamides, and primary sulfamates.
Progress on Polyolefin/Graphene Nanocomposites with High Dielectric
Constant and Low Dielectric Loss for Electrical Applications
Authors: Aldosari Haia , Madkhali Nawal , Algasser Saja , Khairy M. 
Published: July 2023

Introduction:
The attached oxygen functional group in graphene oxide (GO) with layers
that are about 1.1 ± 0.2 nm thick, has hindered the performance of electrical characteristics. Diminution
of the oxygen functional group, and increasing the carbon/oxygen (C/O) ratio can enhance electrical
conductivity.

Method:
This study investigated the effect of graphene derivatives (C/O) ratios on the dielectric properties
of low-density polyethylene (PE) made of metallocene, as well as polypropylene (PP)
and mixtures of them. The oxygen functional groups were reduced by utilizing graphene oxide (GO)
and reduced graphene oxide (rGO). The effect of GO and rGO-based polyolefin produced by solution
blending while lowering the oxygen functional group is explored.

Result:
The surface morphology and chemical structure were examined by using a scanning electron
microscope (SEM) and Fourier Transformed Infrared Spectroscopy (FTIR). The electrical characteristics
of the composite films, such as their loss factor (tan δ) and dielectric constant, permittivity and
conductivity, and imaginary permittivity were examined. At room temperature, measurements were
performed at frequencies ranging from 300 Hz to 8 MHz. ε'; the dielectric permittivity and imaginary
permittivity (ε") of polymer/ reduced graphene oxidehowever, these values rapidly decreased with increasing

Conclusion:
The alternating current conductivity of the composites was likewise shown to increase
with increasing frequency.
Dimensions of Interactive Pervasive Game Design: Systematic Review
Authors: Kai Liu , Tan Wee Hoe , Saari Erni Marlina 
Published: July 2023

Background
As the gaming industry grows around the world, playing pervasive games is becoming an important mode of entertainment. A pervasive game is one in which the game experience extends into the actual world or where the fictive world of the game merges with the physical world. How pervasive games can adapt to the ever-changing nature of technology and design in current society requires a comprehensive review.

Objective
In this systematic review, we aimed to measure and analyze 4 dimensions of pervasive games through development, technology, experience, and evaluation. Moreover, we also aimed to discover and interpret their relationship with game, interaction, experience, and service design.

Methods
We first chose 3 well-known databases, Web of Science, Scopus, and EBSCO, and searched from 2013 to April 2022. A strictly thorough Boolean search for research keywords such as “pervasive game,” “design,” and “interactive” resulted in 394 relevant articles. These articles were identified, screened, and checked for eligibility to find valid and useful articles, which were then categorized and analyzed using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method.

Results
The systematic selection was finally left with 40 valid and valuable articles. After categorization and analysis, all articles were classified according to 4 main themes, which were design and development (11/40, 28%), interaction and technology (15/40, 38%), users and experience (9/40, 23%), and evaluation and service (5/40, 13%). These 4 main areas can be subdivided into several smaller areas.

Conclusions
In the 4 areas of game design, interaction design, experience design, and service design, many scholars have studied pervasive games and made contributions. Although the development and technology of pervasive games have evolved with the times, there is still a need to strengthen emerging design concepts within pervasive games.
Pengaruh Latar Belakang Pendidikan, Pemanfaatan Teknologi Informasi dan Pemahaman Akuntansi Terhadap Kualitas Laporan Keuangan Pemerintah Daerah (Studi Pada OPD di Pemerintah Kabupaten Muara Bungo)
Authors: Wulan D Anissa , Yudi Yudi , Friyani Rita 
Published: July 2023

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh latar belakang pendidikan, pemanfaatan teknologi informasi dan pemahaman akuntansi terhadap kualitas laporan keuangan pemerintah daerah di Kabupaten Muara Bungo, mengingat Pemerintah Kabupaten Muara Bungo mendapat opini wajar tanpa pengecualian dari Badan Pemeriksaan Keuangan Republik Indonesia (BPK-RI) untuk Laporan Keuangan Pemerintah Daerah (LKPD) tahun 2018.
Populasi dalam penelitian ini adalah seluruh OPD yang ada di Kabupaten Muara Bungo. Data yang digunakan adalah data primer yang diperoleh dari responden melalui penyebaran kuesioner. Responden dalam penelitian ini adalah kepala subbagian keuangan dan staff subbagian keuangan. data diperoleh kemudian dilakukan analisis regresi linier berganda antara variabel independen dengan variabel dependen baik secara parsial maupun secara simultan.
Hasil penelitian menunjukkan bahwa : (1) latar belakang pendidikan tidak berpengaruh terhadap kualitas laporan keuangan pemerintah daerah, (2) pemanfaatan teknologi informasi berpengaruh terhadap kualitas laporan keuangan pemerintah daerah, (3) pemahaman akuntansi berpengaruh terhadap kualitas laporan keuangan pemerintah daerah, (4) latar belakang pendidikan, pemanfaatan teknologi informasi, dan pemahaman akauntansi secara simultan berpengaruh terhadap kualitas laporan keuangan pemerintah daerah.
IMPLEMENTASI K-MEANS DALAM PENGELOMPOKAN PENYEBARAN PENYAKIT DBD DI JAWA BARAT
Authors: Rosiana Puput Silva , Mohsa Alpin Apriliansyah , Umaidah Yuyun 
Published: July 2023

Penyakit menular ini disebut penyakit demam berdarah atau DBD adalah penyakit infeksi virus aedes aegyppti yang akut yang disebabkan oleh virus dengue yang di tularkan melalui gigitan pada nyamuk. Berdasarkan tahun 2020, terjadi 24 ribu kasus infeksi DBD di Provinsi Jawa Barat. Maka dari itu, pada penelitian ini mengenai penyakit atau infeksi virus DBD pada Provinsi Jawa Barat menjadi sangat penting untuk dilakukan penelitian untuk menemukan pola penyebaran pada kasus ini. Data yang digunakan dalam penelitian ini berasal dari Open Data Jawa Barat, yaitu portal resmi data terbuka milik Pemerintah Provinsi Jawa Barat. Data yang diambil adalah data yang terkait dengan kasus infeksi Demam Berdarah Dengue (DBD) berdasarkan provinsi dari tahun 2014 hingga 2021. Open Data Jawa Barat menyediakan data dari Perangkat Daerah di lingkungan Pemerintah Provinsi Jawa Barat guna memenuhi kebutuhan masyarakat akan data yang akurat dan terkini. Kemudian data ini akan diseleksi, dari total terdapat 9 atribut hanya 3 atribut saja yang dipilih yaitu nama kabupaten kota, jumlah kasus, dan tahun. Jumlah anggota cluster 0 menunjukan 139 data dan kriteria rendah 139 data, lalu untuk cluster 1 menunjukan 33 data dengan kriteria tinggi 33 data, dan untuk cluster 2 memiliki 260 data dengan kriteria sedang 260 data. Evaluasi yang digunakan yaitu dengan teknik silhouette score dengan hasil score 0,5931974349414901.
Formulasi Dan Uji Aktivitas Antibakteri Sediaan Sabun Cair Ekstrak Bunga Cengkeh (Syzygium aromaticum L.) Dengan Variasi Konsentrasi Carbopol 940 Terhadap Bakteri Staphylococcus aureus ATCC 25923
Authors: Khatimah Husnul , Aisiyah Siti , Wulandari Destik 
Published: July 2023

Liquid soap is one of the preparations to prevent skin infections caused by bacteria. One of the bacteria that causes infection is Staphylococcus aureus. The content of flavonoids, tannins and alkaloids found in clove flowers (Syzygium aromaticum L.) can inhibit antibacterial activity. This study aims to determine the effect of varying concentrations of carbopol 940 on the physical quality of liquid soap preparations of clove flower extract, having antibacterial activity against Staphylococcus aureus bacteria and which formula has the best physical quality. The results showed that variations in carbopol 940 affected the physical quality of the liquid soap preparation, i.e. the increasing concentration of carbopol 940 affected the viscosity and free alkali. All formulas have antibacterial activity of 26.27 (F4); 25.90 (F5); 25.52 (F6). The formula with the best physical quality and antibacterial activity was formula 4 with a concentration of 0.5% carbopol 940 and had an inhibitory effect on bacteria of 26.27 mm. AbstrakSabun cair adalah salah satu persiapan untuk mencegah infeksi kulit yang disebabkan oleh bakteri. Salah satu bakteri yang menyebabkan infeksi adalah Staphylococcus aureus. Kandungan flavonoid, tanin, dan alkaloid yang ditemukan dalam bunga cengkeh (Syzygium aromaticum L.) dapat menghambat aktivitas antibakteri. Penelitian ini bertujuan untuk menentukan efek variasi konsentrasi carbopol 940 pada kualitas fisik dari persiapan sabun cair ekstrak bunga cengkeh, yang memiliki aktivitas antibakteri terhadap bakteri Staphylococcus aureus, dan formula mana yang memiliki kualitas fisik terbaik. Hasil penelitian menunjukkan bahwa variasi carbopol 940 mempengaruhi kualitas fisik dari persiapan sabun cair, yaitu peningkatan konsentrasi carbopol 940 mempengaruhi viskositas dan alkali bebas. Semua formula memiliki aktivitas antibakteri sebesar 26,27 (F4); 25,90 (F5); 25,52 (F6). Formula dengan kualitas fisik dan aktivitas antibakteri terbaik adalah formula 4 dengan konsentrasi carbopol 940 0,5% dan memiliki efek penghambatan bakteri sebesar 26,27 mm.
The presence of anthracosis is associated with the environmental air quality of zoo, wildlife, and companion animals in Jeollabuk-do Province, South Korea
Authors: Leya Mwense , Oh Byungkwan , Ha Seungmin , Bao Tien Huyen Ton Nu , Cha Jang Ock , Park Seok-Chan , Han Jae-Ik , Lim Chae Woong , Kim Bumseok 
Published: July 2023

Abstract

OBJECTIVE
To determine pulmonary anthracosis in zoo, wildlife, and companion animals of Jeollabuk-do Province, South Korea.

ANIMALS
A total of 350 animals of 61 different species, belonging to 3 classes (mammals: n = 38; avian: 21; and reptiles: 2) from different habitats in Jeollabuk-do Province, were examined.

PROCEDURES
Gross lung examination and tissue sampling were done at postmortem, and histopathological analysis was microscopically done on hematoxylin and eosin–stained slides.

RESULTS
Macroscopic analysis of anthracotic lung tissue revealed minute (pinpoint size) spots and black pigmentation in a scattered and/or coalescing fashion. The presence of carbon particles was noted in 154 (44%, 154/350) cases. Based on habitation, zoo animals had the highest frequency of anthracosis in the lung (55.2%, 69/125), followed by companion animals (45.2%, 56/124) and wildlife animals (28.7%, 29/101). There was an association between habitation and the presence of anthracosis (P < .05).

CLINICAL RELEVANCE
This study revealed evidence that the presence of anthracosis is associated with the environmental air quality of zoo, wildlife, and companion animals in Jeollabuk-do Province, South Korea. Air pollution may affect the respiratory health of the endangered species at the Jeonju Zoo as well as the human population. Continuous monitoring of particulate matter and establishing policies that control industrialization around the province would enable quick action to curb any potential respiratory health risks to animals kept in the urban cities of the province.
Vertebral fixation does not affect recovery or recurrence of cervical intervertebral disc herniation in small dogs (< 15 kg)
Authors: Kikuchi Yuki , Takahashi Fumitaka , Toki Minae , Shimada Masakazu , Hara Yasushi , Yamaguchi Shinya 
Published: July 2023

Abstract

OBJECTIVE
To compare the prognosis of small dogs with cervical intervertebral disc herniation (C-IVDH) when treated with ventral slot decompression (VSD) alone or with concomitant vertebral fixation (VF).

ANIMALS
Small dogs (n = 303) weighing < 15 kg diagnosed with C-IVDH and treated with VSD.

PROCEDURES
We recorded signalment, cervical myelopathy grade, surgical site, use of VF, degree of adjacent disc degeneration, recovery, recurrence, recurrence site, and postoperative course, including the time elapsed from recovery to recurrence. We examined factors associated with recovery and recurrence during the 30-month postoperative period using multivariate logistic regression analysis.

RESULTS
VF did not affect recovery (P = .79). However, nonchondrodystrophic breeds had poorer recovery (OR, 5.89; P = .023) than chondrodystrophic breeds, and a higher preoperative cervical myelopathy grade (grade 3 or 4) was associated with poorer recovery (OR, 7.09 or 3.46, respectively; P = .019 or .042, respectively), compared with grade 1. VF did not affect recurrence (P = .79); however, increasing age was associated with recurrence (OR, 1.79; P = .001).

CLINICAL RELEVANCE
In small dogs weighing < 15 kg, there was no difference in postoperative recovery and recurrence rates after VSD with or without concomitant VF. Therefore, in small dogs with C-IVDH, even if the slot volume is increased to remove sufficient disc material during VSD, a good prognosis can be achieved with or without VF.
Addition of two full-thickness simple interrupted sutures to standard incisional gastropexy increases gastropexy biomechanical strength
Authors: Pan Yi , Mann F. A. , Wagner-Mann Colette , Winholtz R. A. 
Published: July 2023

Abstract

OBJECTIVE
To compare the acute strength (failure load and work to failure) of standard incisional gastropexy (SIG) and modified incisional gastropexy (MIG).

ANIMALS
37 pig cadavers.

PROCEDURES
Stomachs and right abdominal walls were harvested from pigs euthanized for reasons unrelated to this study. The tissues were stored in lactated Ringer’s solution overnight in a 5 °C cooler. Matching body wall and stomach tissue pairs were randomized and divided into 2 groups, on which either SIG or MIG was performed the following day. The MIG technique was identical to SIG except 2 additional simple interrupted sutures, 1 cranial and 1 caudal to the continuous suture line, were placed full thickness into the stomach to ensure engagement of the submucosa. After gastropexy, the samples underwent biomechanical testing. Information regarding change in position and load was generated by the MTESTQuattro software. Mode of failure was examined after the procedure was complete.

RESULTS
The MIG had higher failure load and work to failure compared to SIG. All failures were caused by gastric tissue tearing.

CLINICAL RELEVANCE
The MIG is biomechanically superior to SIG and may provide more security than SIG during healing. However, clinical study is needed to ascertain if there is a difference in gastropexy failure and complications between these 2 techniques.
Using a mixed layered soil model to optimize the layout of coastal direct current (DC) grounding electrodes
Authors: Liu Xuan , Deng Changzheng , Han Xinyue , Zhong Shiling , Liu Jiaming 
Published: July 2023

Abstract
In recent years, with the rapid development of the coastal economy and the large-scale development of marine resources, power demand has risen sharply. So it is urgent to promote the construction of UHVDC projects. Coastal saline areas often contain more chloride and other salts than other inland areas due to the high humidity, salinity and light intensity of the marine climatic and environmental conditions, which lead to the different electrical performance of grounding electrodes under different layouts. Therefore, one of the key issues to realizing the rapid development of UHVDC in coastal countries is how to choose the best layout of the coastal DC grounding electrode. It is intended to simulate the coastal environment and establish a mixed stratified soil model using CDEGS to verify the validity of the model through experiments in this paper. Based on the mixed soil model, the changes in grounding resistance, surface potentials and step voltage of grounding electrode sites under zigzag shape, two-row and circular shapes layouts are studied. The results show that when the zigzag shape layout is selected, the ground potential amplitude of the grounding electrode is reduced by 45.77% and 42.7%, the step voltage amplitude is decreased by 39.85% and 32.22%, and the grounding resistance is decreased by 28.45% and 27.68%, compared with the two-row and circular layout. In addition, its utilization rate of electrodes is better than the other two layout shapes.
Innovative reform strategy of college music education art practice based on information fusion technology
Authors: Deng Meng 
Published: July 2023

Abstract
This paper is designed to improve the efficiency and quality of teaching and learning efforts and to meet the multidimensional information needs of music educators and learners. From the perspective of information fusion technology, we build a multi-source information fusion system based on the basic system architecture. The maximum likelihood, least squares, and D-S algorithms were used to calculate and construct the sampling evaluation index equations. A survey of the teaching methods used in music teaching in colleges and universities was conducted to analyze three strategies needed for college education reform: innovative teaching methods, strengthening teachers’ music competence and quality, and establishing feedback mechanisms for college music teaching evaluation. The combined survey results show that 72% of music teachers believe their teaching skills have been greatly enhanced, while students’ willingness to take music lessons after using information integration technology has all risen to over 80%.Therefore, in the process of music teaching in colleges and universities, the integration of information integration technology can not only improve students’ interest in learning but also improve teachers’ teaching ability, which provides a certain degree of reference for the reform of music teaching in colleges and universities.
Innovative reform strategy of Chinese language and literature education practice for college students based on information fusion technology
Authors: Zeng Xiao 
Published: July 2023

Abstract
With the rapid development and updating of information technology and the gradual increase of economic and social influence, the Chinese language, as an important discipline in China’s higher education, has undergone a great transformation in its teaching conditions and teaching environment in the information age. To obtain more reliable information and better reform and innovation, this paper analyzes the machine model established based on information fusion and investigates the employment situation of Chinese language and literature graduates in university colleges and universities in the past five years to analyze the improvement of employment under the information fusion model establishment. The results show that the teaching process of Chinese language and literature can be well optimized through the machine learning model and is no longer homogeneous compared with the traditional teaching process of Chinese language and literature. The information fusion model can provide a certain degree of help in the employment of students in this major. Therefore, the introduction of information fusion technology is indispensable in the process of reform and innovation of the Chinese language and literature, and schools should also increase relevant courses and policies to encourage college students to actively cooperate with the reform and practice process.
Analysis on the path of integrating traditional culture into illustration design based on visual communication
Authors: Hu Wenbo 
Published: July 2023

Abstract
The illustration is a very intuitive form of language expression in modern graphic design. It expresses character scenes, allegorical dialogues, etc. in the form of vivid paintings. Synthesizing the connotation and form of all aspects from literature to art. Illustration art pervades all areas of daily life. It can be said that its formal beauty has become a fashion trend in the decorative art world. Based on the back-propagation algorithm, this paper constructs a BPA-transformation model. Through comparative analysis, it can be seen that illustrations that are not integrated into the theme of Peking Opera have low story inclusion, only 45%. As for the illustrations that incorporate Peking Opera themes, the storyline is highly inclusive, accounting for 68%. Illustrations that incorporate traditional Peking Opera themes are highly realistic, up to 93%. Through comparative analysis, the integration of ink and wash artistic conception is relatively high. Ink illustrations are 40% more innovative.
Research on the cultivation and evaluation system of effective teaching ability of college teachers’ classrooms based on artificial intelligence algorithm
Authors: Xu Chang 
Published: July 2023

Abstract
To better improve student performance and make students more receptive to knowledge, a study of artificial intelligence algorithms for the development and evaluation of college teachers’ teaching skills is proposed. Connections are established with multiple neurons in the periphery through dendrites and axons, and weighted integration of neuronal inputs to the next neuron, given an intelligent learning target. The sensitivity is back-propagated in the adjustment of model parameters, and the centroids are selected to calculate the Euclidean distance to obtain an accurate prediction model, and the weight parameters and bias vectors of the model are adjusted. Using a two-by-two comparison to determine the hierarchical factors, the weights of the relative importance of all factors at each level were calculated and ranked, and the multi-level index system was formed according to the constraint relationship between factors. According to the hierarchical structure of the teaching ability of college teacher educators and the opinions of some experts, the weights of each element in each matrix were determined to reasonably evaluate the effective teaching ability of college teachers in the classroom. The analysis results show that the artificial neural network model has a relative error value of about 1.5% and high numerical accuracy in evaluating teachers’ classroom teaching ability by hierarchical analysis.