bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elephant on the Dance Floor: Revealing the Significance of Dancers’ Sex in Coalition Quality Assessments
Authors: Metin Ceren , Tekozel Mert 
Published: August 2023

Abstract
Collective dances are considered to serve as a strategic tool to convey information about the internal stability and collective action capabilities of performing coalitions. This communicative function not only aids in ally recruitment but also facilitates decision-making to manage conflicts within coalitions. While previous empirical studies mainly focused on mechanical aspects like dance simultaneity, the influential role of dancers' sex, a crucial coalitional component, is often overlooked. Considering that sex is detected very quickly and automatically by others, ignoring dancers’ sex may make the ecological validity of previous findings questionable. Moreover, no research currently examines how dancers’ sex influences the coalition quality assessments made by passive observers. To address this gap, the present study investigates potential differences in coalition quality ratings between dances performed solely by males and females. Drawing from the evolutionary perspective on male participation in coalitional dynamics, particularly the outgroup male target hypothesis, we propose that male dancers would be perceived as having higher coalition quality than female dancers, and dancers’ sex effect would exceed the effect of movement simultaneity type. The results confirm our hypothesis, highlighting that it is dancers' sex, rather than movement simultaneity type, that plays a primary role in coalition evaluations. Implications are discussed through the lens of error management theory, the outgroup male target hypothesis, and the recognition of sex as a dominant social cue.
Ureteral stricture formation after endoscopic removal of obstructing stones: Could it be predicted with well assessed radiological parameters?
Authors: Sahin Cahit , Sobay Resul , Arikan Ozgur , Uslu Mehmet , Bicaklioglu Fatih , Karaca Yavuz , Sahinler Emre Burak , Sarica Kemal 
Published: August 2023

Abstract
The possible role of well-assessed radiological parameters in the prediction of ureteral stricture formation in cases with impacted obstructive ureteral calculi has been evaluated 46 adult patients with or without ureteral stricture formation after ureteroscopic stone management were included. In addition to stone size and some certain radiological parameters including ureteral wall thickness (UWT ) of the involved ureter at the impacted stone site was also measured and noted on computed tomography (CT) images. Parameters were evaluated in two subgroups of cases namely: Group 1: patients in whom a ureteral stricture formed after endoscopic stone removal and Group 2: patients normal ureteral anatomy without any stricture formation. The possible relationship between the UWT values and degree of hydronephrosis (HN) with subsequent stricture formation was comparatively evaluated. All of the stones were proximal ureteral calculi in both groups. Both the degree of HN and proximal ureteral diameter (PUD) parench was higher in cases with stricture formation. Additionally, mean parenchymal thickness was lower and mean values of UWT measurements at the stone site were 3.70 ± 0.97mm and 2.17 ± 0.26 mm in Group 1 and 2 respectively. A cut off value 2.49 mm for UWT was found to be highly predictive for stricture formation. UWT value calculated at the obstructing stone site was found to be predictive enough for the likelihood of ureteral stricture formation with high sensitivity and specifcity. This evaluation along with some other radiological parameters may enable the urologists to follow such cases on this aspect with necessary mesaures taken.
Statins Effect on Oncologic Outcome in Larynx Squamous Cell Carcinoma: Commentary on Our Clinical Experience
Authors: Zoccali Federica , Vincentiis Marco , Colizza Andrea , Cicala Stefano Domenico , Greco Antonio , Zaccarelli Fabiana , Niccolini Giovanni Francesco , Filaferro Luca , Fusconi Massimo 
Published: August 2023

Abstract
Background Some studies have suggested a protective role of statins in Head and Neck Squamous Cell Carcinoma (HNSCC) even though the real contribution of statins to morbidity and survival remains unclear.Porpose The aim of this study is to correlate the statin intake with the incidence and the prognosis of larynx cancer.Study Design Observational retrospective case-control with a consecutive enrollment.Methods The aim of this study is to retrospectively evaluate the oncological protection and the outcome of the statin intake in a population of patients affected by larynx squamous cell carcinoma that underwent total or partial laryngectomy. We enrolled and analyzed statin intake among 157 patients. Overall survival (OS) was compared between patients underwent total or partial laryngectomy assuming statin or not. We analyzed if statin intake could be statistically significant in increasing the overall survival. We also evaluated whether a less advanced stage of the tumor could be related to statin intake.Results The Kaplan-Meier survival curves for oncologic population assuming statins was 96.8% while it was 92.4% for patients that were not assuming statins. The Cox multivariate regression analysis didn’t identify a statistically significant OS benefit with statin intake.Conclusions Statin intake at the time of diagnosis of squamous cell carcinoma of the larynx has shown an improved OS even though statin consumption didn’t appear as a statistically significant variable probably due to the small number of patients analyzed.
Blockchain-based verifiable multi-keyword searchable encryption scheme with de-duplication support
Authors: Feng Tao , Qiu Zhen , Fang Junli , Wu Yi , Ma Rong 
Published: August 2023

Abstract
Searchable encryption technologies aim to retrieve data stored in ciphertext on cloud servers. However, the imperceptible flaws of cloud servers, such as data corruption and data duplication, are prone to trigger concerns of data owners about economic damage and privacy disclosure in the era of the digital economy. Moreover, single-keyword searchable encryption fails to cater to the fine-grained and diversified search demand in practical settings. Additionally, the revolutionary blockchain technology is propelling the evolution of trade fairness. Hence, we proposed a fine-grained multi-keyword searchable encryption scheme based on blockchain under the Modify Decisional Diffie-Hellman (MDDH) assumption. Specifically, ameliorated ciphertext-policy attribute-based encryption is employed to realize fine-grained access and attribute revocation, and data label technology is adopted to achieve de-duplication. Finally, the security analysis and experimental results show that our scheme achieves desired practical security and performance goals.
Psychomotor development, emotional regulation, and executive functions in 2-years-old children after a threatened preterm labour: a prospective study
Authors: Campos-Berga Laura , Moreno-Giménez Alba , Almansa Belén , Ghosn Farah , Buesa Julia , Lizarán Marta , Diago Vicente , Vento Máximo , García-Blanco Ana 
Published: August 2023

Abstract

Objective
A threatened preterm labour (TPL) represents an adverse prenatal event with potential long-term consequences on offspring’ neurodevelopment, regardless of prematurity condition. The aim of this study was to assess TPL impact on children’s psychomotor and socioemotional development at 2 years of age.
Methods
A cohort of mother-infants was recruited at the time of TPL diagnoses and followed up until 30 months of children’s corrected age. Participants were classified in three groups regarding gestational age at delivery: Full-term TPL (n = 35), Late Preterm TPL (n = 67), Very Preterm TPL (n = 41). A Control group (n = 62) of mothers without TPL and their infants born at term completed the sample. Children’s assessment was performed using the Ages & Stages Questionnaires for psychomotor development, the Early Childhood Behavior Questionnaire–Very Short Form for temperament, and the Behavior Rating Inventory of Executive Function-Preschool Version for executive functions. Then, MANCOVA were conducted to detect differences between groups.
Results
TPL children, regardless of delivery time, showed worse emotional regulation (ps < .03) and more inhibition problems (ps < .02) than control ones. In addition, Very preterm TPL children exhibited lower psychomotor development (ps ≤ .040), more difficulties in working memory (ps ≤ .002) and planification/organization (ps ≤ .003) domains.
Conclusion
TPL per se may represent a risk factor for children’s neurodevelopmental disturbances, specifically in emotional and regulation competences, even in the absence of prematurity.
“PBT-SCREEN”, a high-throughput screening platform to identify new therapeutic agents for Medulloblastoma Group 3
Authors: Fallon Ines , Hernando Henar , Almacellas Olga , Marti-Fuster Berta , Spadoni Cesare , Méndez Eva , Bigner Darrell D 
Published: August 2023

Abstract
Background
Pediatric brain tumors (PBTs) represent about 25% of all pediatric cancers and are the most common solid tumors in children and adolescents. Medulloblastoma (MB) is the most frequently occurring malignant PBT, accounting for almost 10% of all pediatric cancer deaths. MB Group 3 (MB G3) accounts for 25–30% of all MB cases and has the worst outcome, particularly when associated with MYC amplification. However, no targeted treatments for this group have been developed so far. PBTs differ significantly from their adult counterparts in terms of driver genetic mutations, origin, and tumor microenvironment. As a result, drugs approved for adults often fail to be effective or lead to undesirable toxicity in children.
Methods
We have used a broad panel of pediatric MB G3 and healthy human cell lines to develop in vitro efficacy and toxicity assays, both in 2D and 3D and in high-throughput screening (HTS) format. A pilot HTS campaign with 1.280 lead-like compounds was performed to validate the screening platform.
Results
We have set up, optimized, and validated 2D and 3D efficacy and toxicity models ensuring that they correctly identify positive and negative compounds, and a high reproducibility, so they could be used in our screening platform. PBT-SCREEN was further validated by conducting a pilot HTS campaign, detecting 8 active compounds against MB cell lines. All detected hits were acting via caspase activation. Compounds targeted 6 MB-related cancer targets, some of them currently approved or in clinical trials in pediatric patients with PBTs, including MB. Hits were then combined, identifying 3 synergistic combinations, one currently being studied in the clinics for recurrent MB and other PBTs.
Conclusion
We have set up and validated PBT-SCREEN, an HTS pediatric platform specifically designed to identify new therapies for MB G3 patients. PBT-SCREEN accounts for tumor heterogenicity, limited efficacy, and unacceptable toxicity from the very early stage of drug development, which makes it an ideal in vitro tool to develop new drugs that are not only effective but safer for children with medulloblastoma. Its versatility extends to various PBTs, therefore providing targeted therapies to pediatric brain tumors that are crucial.
The Challenges of Ensuring Quality Education at Tertiary Level: An Assessment of Comilla University
Authors: Al-Amin Mohammad , Al-Amin Mohammad 
Published: August 2023

Abstract
The essence of quality education at the tertiary level is inevitable and part of the parcel of nation-building in the technological era because of the foundation of a country. The prime purpose of the state has to assure standard education at all levels to improve social, economic, political, and cultural advancement. It is found that some vital elements such as infrastructural settings, institutional and financial supports, research atmosphere, standard curriculum, teachers’ skills and recruitment, library and lab facilities, and other environmental factors influence the quality of higher education. However, still, now Bangladesh fighting with several major drawbacks for ensuring the quality of higher education. The objective of the present study is to investigate the challenges in terms of academic issues and environmental drawbacks at Comilla University. The study was conducted based on a mixed method using primary and secondary data where primary data was collected by using a survey questionnaire and Key Informative Interviews (KIIs). It is revealed that unplanned infrastructure, poor institutional supports, insufficient residential settings, lack of library facilities, research environment, absence of ingredients and cooperation, accountability, security and hygiene, political stability, poor curriculum and training, and misuse of resources hinder the quality education of Comilla University. The potential recommendations are provided to take immediate steps by UGC, the government, and University’s internal authority to improve the present circumstances.
Experimental evaluation on the effect of biochar addition with anaerobic digestion of the tannery wastewater to improve biogas production
Authors: Asefa Solomon Kebede , Ancha Venkata Ramayya , Habtu Nigus Gabbiye , Sundar Lingala Syam 
Published: August 2023

Abstract

The use of biochar as an additive material in various compositions to the anaerobic digestion of the tannery wastewater was investigated. Pyrolytic biochar made from Khat waste with different compositions was added to anaerobic batch digesters in laboratory-scale experiments. Biogas digesters of 500 ml volume were used to explore the effects of biochar on anaerobic digestion in the ratios of 5, 10, 15, and 20% (w/w) at constant mesophilic temperature (38 °C). The results show that for five experimental tests in digesters (D0, D1, D2, D3, and D4), which contains 0, 5, 10, 15, and 20% of biochar, the cumulative methane and biogas yields were, respectively, 17.04, 41.2, 43.8, 51.6, 48.6% and 150, 520, 680, 760, 690ml. Compared to the cumulative methane production efficiency of the digester without biochar (D0), the addition of 5, 10, 15, and 20% biochar had more favorable effects and increased the efficiency by 58.6, 61.1, 66.98, and 64.94%, respectively. From these results, adding 15% of biochar to anaerobic digestion causes a three-fold increase in methane compared to the control and more positive effects than all other biochar compositions. According to this result, the right dose of biochar must be added to maximize biogas production.
Biochemical Aspects of the Spiral Grain Formation in Scots Pine (Pinus
Sylvestris L.) Wood. Some Differences and Similarities with Biochemical
Indicators of Abnormal Xylogenesis in Karelian Birch (Betula Pendula
Roth Var. Carelica (Mercl.) Hämet-Ahti)
Authors: Nikerova Kseniya Mihajlovna , Galibina Natalia Alekseevna , Sinkevich Sergey Mihajlovich , Sofronova Irina Nikolaevna , Borodina Marina Nikolaevna , Moshchenskaya Yuliya Leonidovna , Tarelkina Tatiana Vladimirovna , Klimova Anna Vladimirovna 
Published: August 2023

Background:
AOS enzymes can be biochemical indicators of abnormal xylogenesis in
Scots pine, and this mechanism has similar features with the metabolic base of abnormal xylogenesis
in Karelian birch.

Objective:
AOS enzymes’ activity in 150-300-year-old Pinus sylvestris L. wood with straight--
grained wood and right-twisted spiral-grained wood, expressed in varying degrees (5-20 angle),
grew in three sample plots in lingonberry and blueberry pine forest stands of different ages
(100-300 years) in the middle taiga subzone in the Republic of Karelia.

Methods:
Plant tissues were ground in liquid nitrogen in a uniform mass and homogenized at 4°C in
the buffer containing 50 mM HEPES (pH 7.5), 1 mM EDTA, 1 mM EGTA, 3 mM DTT, 5 mM
MgCl2 and 0.5 mM PMSF. After 20 min extraction, the homogenate was centrifuged at 10000 g for
20 min (MPW-351R, Poland). The sediment was washed in the buffer thrice. The pooled supernatant
and sediment were dialyzed at 4°C for 18-20 h against a tenfold diluted homogenization buffer.
The enzymes' activity was determined spectrophotometrically (Spectrophotometer SF-2000,
OKB Spectr, Russia). Proteins in the extracts were quantified by the method of Bradford.

Results:
The study showed that the activity of SS, ApInv, CAT, POD and PPO in xylem and PPO
in phloem were biochemical indicators for abnormal wood of P. sylvestris. We noticed an increase
in sucrose metabolism in the apoplast and the activity of POD and PPO under spiral-grain wood
formation like under figured wood formation earlier. We assume that the alternative pathway of sucrose
metabolism (an indicator of abnormal xylogenesis in B. pendula var. carelica plants) that
lead to restructuring of AOS enzymes have the same biochemical regularities in the spiral-grain
wood formation in P. sylvestris.

Conclusion:
The study showed that the differences in the AOS enzyme's activity in P. sylvestris
during the formation of straight-grained and spiral-grained wood were revealed for the first time.
The increased CAT, POD and PPO activities in xylem with a decrease in SS and an increase in Ap-
Inv during spiral-grained wood formation can be biochemical markers of these structural anomalies.
Metabolic regularities found in the AOS enzyme complex during spiral-grained wood formation
do not contradict those found earlier during figured wood formation in B. pendula var. carelica.
The identified patterns can form the base for diagnostics of P. sylvestris wood quality in forest
seed plantations and in their natural growth, which is necessary both for fundamental science and
in various industry areas while high-quality material harvesting.
Development and Validation of a Risk Prediction Algorithm for
Evaluating the Efficacy of Postoperative Adjuvant TACE Therapy for
Hepatocellular Carcinoma
Authors: Tao Jie , Shi Xiaoli , Feng Xu , Wu Xinhua , Qi Shiguai , Feng Guoying , Yang Xu , Zhao Yufei , Zuo Hangjia , Shi Zhengrong 
Published: August 2023

Background and Purpose:
There is a lack of a reliable outcome prediction model for
patients evaluating the feasibility of postoperative adjuvant transarterial chemoembolization (PATACE)
therapy. Our goal was to develop an easy-to-use tool specifically for these patients

Methods:
From January 2013 to June 2017, patients with hepatocellular carcinoma from the Liver
Center of the First Affiliated Hospital of Chongqing Medical University received postoperative adjuvant
Transarterial chemoembolization (TACE) therapy after liver cancer resection. A Cox proportional
hazards model was established for these patients, followed by internal validation (enhanced
bootstrap resampling technique) to further evaluate the predictive performance and discriminanceevaluate
the predictive performance and discriminance, and compare it with other predictive
models. The prognostic factors considered included tumour number, maximum tumor diameter,
Edmondson-Steiner (ES) grade, Microvascular invasion (MVI) grade, Ki67, age, sex, hepatitis
B surface antigen, cirrhosis, Alpha-fetoprotein (AFP), Albumin-bilirubin (ALBI) grade, Childpugh
grade, body mass index (BMI), Neutrophil-lymphocyte ratio (NLR), Platelet-to-lymphocyte
ratio (PLR).

Results:
The endpoint of the study was overall survival. The median overall survival was 36
(95%CI: 34.0-38.0) months, with 1-year, 2-year and 3-year survival rates being 96.3%, 84.0% and
75.3%, respectively. Tumour number, MVI grade, and BMI was incorporated into the model,
which had good differentiation and accuracy. Internal validation (enhanced bootstrap) suggested
that Harrell’s C statistic is 0.72. The model consistently outperforms other currently available
models.

Conclusion:
This model may be an easy-to-use tool for screening patients suitable for PA-TACE
treatment and guiding the selection of clinical protocols. But further research and external validation
are required.
Neuroendocrinological and Clinical Aspects of Leptin
Authors: Yanik Tulin , Durhan Seyda Tugce 
Published: August 2023

Abstract:
Obesity is characterized by an abnormal increase in adipose tissue mass and is regarded as
a neurobehavioral as well as a metabolic disorder. Increases in body fat are caused by even slight,
long-term discrepancies between energy intake and energy expenditure. It is a chronic condition
linked to the metabolic syndrome, a spectrum of risky conditions, such as diabetes, high blood pressure,
and heart disease. With a swiftly rising prevalence, obesity has emerged as a significant global
health concern. Leptin influences the brain’s neuroendocrine and metabolic processes, which is important
for maintaining energy homeostasis. White adipose tissue secretes the majority of leptin, and
there is a positive correlation between leptin levels in the blood and body fat percentages. The central
nervous system is also modulated by leptin levels to modify energy intake and usage. The idea of an
obesity cure sparked excitement after it was discovered more than 25 years ago. However, the leptin
medication only effectively reduces weight in patients with congenital leptin insufficiency and not in
patients with typical obesity who may also have leptin resistance. Recent research has focused on the
role of leptin in managing weight reduction and preventing “yo-yo dieting”. This review concentrates
on the neurological effects of leptin with a focus on therapeutic and diagnostic applications, particularly
for childhood obesity.
Alterations in Peripheral Metabolites as Key Actors in Alzheimer’s Disease
Authors: Sheng Can , Chu Xu , He Yan , Ding Qingqing , Jia Shulei , Shi Qiguang , Sun Ran , Song Li , Du Wenying , Liang Yuan , Chen Nian , Yang Yan , Wang Xiaoni 
Published: August 2023

Abstract:Growing evidence supports that Alzheimer’s disease (AD) could be regarded as a metabolic disease, accompanying central and peripheral metabolic disturbance. Nowadays, exploring novel and potentially alternative hallmarks for AD is needed. Peripheral metabolites based on blood and gut may provide new biochemical insights about disease mechanisms. These metabolites can influence brain energy homeostasis, maintain gut mucosal integrity, and regulate the host immune system, which may further play a key role in modulating the cognitive function and behavior of AD. Recently, metabolomics has been used to identify key AD-related metabolic changes and define metabolic changes during AD disease trajectory. This review aims to summarize the key blood- and microbial-derived metabolites that are altered in AD and identify the potential metabolic biomarkers of AD, which will provide future targets for precision therapeutic modulation.
A Critical Assessment of COVID-19 Genomic Vaccines
Authors: Sabbah Dima A. , Hajjo Rima , Sunoqrot Suhair 
Published: August 2023

Abstract:
Vaccines are instrumental tools to fight against novel and re-emerging pathogens and
curb pandemics. Vaccination has been an integral part of the multifaceted public health response to
the COVID-19 pandemic. Diverse vaccine platforms have been designed and are currently at different stages of development. Some vaccines are still in early biological testing, while others have
been launched after being approved by regulatory agencies worldwide. Genomic vaccines that deliver parts of the viral DNA or RNA to host cells have gained popularity recently due to their high
efficiency and fast manufacture. Furthermore, recent clinical studies encouraged the use of different vaccine platforms within the primary vaccination course to enhance the efficacy of vaccination.
Herein, we discuss COVID-19 genomic vaccines, which deliver viral genetic material to host cells
through diverse biotechnology platforms, including viral vector vaccines, messenger RNA nucleic
acid vaccines, and DNA nucleic acid vaccines. We compare and contrast vaccine characteristics,
composition, and pros and cons among different genomic vaccine platforms as well as non-genomic vaccines. This review summarizes all current knowledge about COVID-19 genomic vaccines,
which could be highly valuable to researchers interested in public health and vaccine development.