bluuebunny/crossref_metadata_2025_split huggingface dataset:
International Teleworking in Latin America
Authors: Kabat Marina 
Published: January 2025

Desde la pandemia, América Latina experimentó un drástico crecimiento del número de trabajadores que se emplean en forma remota para empresas extranjeras. No obstante, los mismos cambios que facilitaron esta expansión del teletrabajo internacional aceleran la competencia global entre trabajadores, lo que junto con la crisis que atraviesa la industria del software, genera despidos y caída salarial. En este contexto, estudiamos las diferentes trayectorias de los países latinoamericanos, los rubros ocupacionales en que cada uno se inserta, las tensiones que estos cambios generan el ámbito doméstico y los desafíos que presentan para pensar estratégicamente el desarrollo regional. Since the pandemic, Latin America has experienced a drastic growth in the number of workers employed remotely by foreign companies. However, the same changes that facilitated this expansion of international teleworking have accelerated global competition between workers. This, along with the current crisis of the software industry, leads to layoffs and a drop in wages. This paper addresses the different paths of several Latin American countries, the occupational categories in which each one is inserted, the tensions that these changes produce in the domestic sphere, and the challenges they entail for thinking strategically about regional development.
Biomechanical Outcomes of Glenoid Bone Graft Fixation Techniques: A Systematic Review
Authors: Brinkman Joseph C. , Lin Eugenia A. , Moore M. Lane , Verma Nikhil N. , Tokish John M. 
Published: January 2025

Background: The Latarjet and other bony augmentation procedures are commonly used to treat anterior shoulder instability in the setting of significant glenoid bone loss. Although several fixation strategies have been reported, the biomechanical strength of these techniques remains poorly understood. Purpose: To perform a systematic review of the biomechanical strength of glenoid bony augmentation procedures for anterior shoulder instability. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic search of the Medline, Embase, Web of Science, and Cochrane Library databases was performed to identify biomechanical studies evaluating various fixation strategies for coracoid and other bone transfer procedures for anterior shoulder instability. Biomechanical results included load to failure with both compression and traction forces, stiffness, and cyclic displacement. The quality of included articles was assessed based on the Quality Appraisal for Cadaveric Studies (QUACS) scale. Results: A total of 21 biomechanical studies comprising 486 specimens were included. The number of screws used and the addition of washers were found to significantly increase rigidity and load to failure. The comparison of fixation techniques demonstrated mixed results in load to failure between screw and alternative constructs including suture buttons and suture anchors. However, studies that tested graft displacement consistently found more graft displacement in buttons compared with screws. The median and mean of the QUACS scale were both 12, with a range of 10-13. Conclusion: Biomechanical studies consistently demonstrated that when glenoid bone grafts were fixed with screws, the number of screws and use of washers significantly increased construct rigidity and load to failure. Different metal screw materials and sizes did not consistently demonstrate a significant difference in biomechanical strength. There are mixed results when comparing suture buttons to screw fixation. The evaluated studies revealed that all double metal screw constructs and the majority of suture button and anchor constructs were able to withstand the glenohumeral load reflective of activities of daily living using a 150-N threshold.
Impact of Apixaban Lead-In Therapy Duration After Parenteral Anticoagulation on Bleeding in Patients Treated for Venous Thromboembolism
Authors: Jackson Lauren , Gillion Amanda , Marler Jacob 
Published: January 2025

Background: Venous thromboembolism (VTE) treatment with apixaban uses a higher 10 mg twice daily regimen for 7 days (lead-in therapy). But, in patients with initial parenteral anticoagulation treatment or those with higher bleeding risk, clinicians may not always adhere to the full 7-day lead-in duration. Methods: This retrospective cohort study included adult patients admitted to the Veterans Affairs Health care System from January 2011 to April 2022, who received at least 24 hours of parenteral anticoagulation followed by lead-in apixaban therapy for VTE. The primary outcome evaluated bleeding among patients treated with shortened lead-in apixaban (study group) compared to the standard 7-day duration (control group). Results: Seventy-eight patients were included in the control and 65 in the study group. Most patients were treated for PE (72%) and received initial treatment with enoxaparin (71%). Duration of parenteral anticoagulation was longer in the study group (3.6 days ± 3.2 vs 2.5 days ± 1.9; P < .01), and length of apixaban lead-in therapy was decreased (4.1 days ± 2.2 vs 7 days; P < .01). The primary outcome of bleeding was higher in the study group (18.5% vs 5.1%; P = .02), with no difference in VTE recurrence. P2Y12 and P-gp inhibitor use, and increased creatinine and age were predictors of bleeding. Conclusion and Relevance: Bleeding events were increased in the study group, and patients with bleeding risk factors may not benefit from apixaban 10 mg twice daily. Larger studies are needed where apixaban lead-in therapy is omitted following parenteral anticoagulation in patients with bleeding risk factors.
Ultrasonographic and pedobarographic evaluation of the effectiveness of extracorporeal shock wave therapy in patients with plantar fasciitis
Authors: Alkan Gokhan , Elbasti Muhammet Sahin , Akgol Gurkan , Gulkesen Arif , Ulusoy Hasan 
Published: January 2025

Background Prior studies showing the effectiveness of extracorporeal shock wave therapy (ESWT) in patients with plantar fasciitis are mostly based on patient-reported measurements. Objective The aim of this study was to demonstrate the effectiveness of ESWT with ultrasonographic and pedobarographic measurements. Methods A total of 50 patients were included in the study. All patients were evaluated before and six weeks after ESWT treatment. Pain was evaluated with the Visual Analogue Scale (VAS), functional status with Foot Function Index (FFI), and quality of life with Short Form-36 (SF-36). Plantar pressure measurements were made with a pedobarography device, and plantar fascia thickness was measured with ultrasonography. Results After treatment, VAS-Pain decreased significantly. There was a statistically significant improvement in FFI scores after treatment. Similarly, a statistically significant improvement was seen in SF-36 scores. There was a significant decrease in ultrasonographic measurements of the plantar fascia thickness in the origo and midsection regions. There was a statistically significant decrease only in medial heel pressure measurements. Conclusion The results of this study showed that ESWT provides symptomatic and functional improvements in patients with plantar fasciitis as well as ultrasonographic plantar fascia thickness and pedobarographic medial heel pressure measurements.
The effects of abdominal muscle contraction using real-time feedback on adults with chronic low back pain: A pilot study
Authors: Choi Jongduk , Seong Jaehyeon 
Published: January 2025

Background This study aimed to examine the influence of real-time feedback on intentional abdominal muscle engagement in adults with chronic low back pain (CLBP) during daily activities. The research further sought to evaluate the outcomes of this training on neuromuscular control, pain perception, and functional capacity. Objective We compared a group of adults who received real-time feedback on changes in waist circumference with a group trained in abdominal contraction without real-time feedback. Methods Surface electromyographic (sEMG) signals were measured in the rectus abdominis (RA), external oblique (EO), internal oblique (IO), and erector spinae (ES) muscles. Pain intensity was assessed using the visual analog scale (VAS), and functional outcomes were assessed using the Oswestry Disability Index (ODI). Results After the intervention, sEMG signals of the RA, EO, and IO muscles were significantly higher in the experimental group. There were no significant differences in ES muscle activity between the groups. Both the experimental and control groups showed significant decreases in VAS and ODI scores after the intervention. Conclusion Intentional abdominal contraction aided by real-time feedback can improve functionality in patients with chronic low back pain.
Does Palatoplasty Technique Impact Resolution of Eustachian Tube Dysfunction?
Authors: Prosak Olivia L. , Du Jennifer , Gao Lily , Patel Kalpnaben R. , Zhao Shilin , Braun Stephan , Golinko Michael , Phillips James D. , Belcher Ryan H. 
Published: January 2025

Objective To determine whether palatoplasty technique affects the resolution of eustachian tube dysfunction and postoperative speech outcomes in children with cleft palate (CP). Design Retrospective cohort. Setting Multidisciplinary cleft and craniofacial clinic at a tertiary care center. Patients Seventy-three patients with nonsyndromic CP who underwent palatoplasty between 2005 and 2019. Inclusion criteria included soft palate repair with Furlow technique or intravelar veloplasty (IVV) and Veau classifications I-III. Interventions Either Furlow or IVV repair was performed based on the surgeon's clinical judgment. All patients had bilateral ear tubes placed prior to or at the time of palate repair, with postpalatoplasty ear tubes placed at the ENT surgeon's discretion. Patients received routine follow-up care for over 5 years. Data were analyzed with Wilcoxon tests, χ2 tests, and negative binomial regression. Main Outcome Measures Number of postpalatoplasty ear tubes placed, rates of velopharyngeal insufficiency, and speech surgery after palatoplasty in each group. Results Furlow repair patients required a similar number of postpalatoplasty ear tubes ( P = .321) and underwent additional sets at similar rates compared to those who underwent IVV repair. Negative binomial regression found no covariates (age, race, Veau, repair type, speech surgery, fistula repair) that predicted additional ear tube requirements. Conclusion Furlow repair patients required postpalatoplasty ear tubes at a similar rate compared to IVV repair patients. While the palatoplasty techniques differ, patients may still need the same amount of time for resolution of their eustachian tube dysfunction.
Mandibular Distraction Osteogenesis vs. Tracheostomy in the Management of Pierre Robin Sequence: A Systematic Review and Meta-Analysis
Authors: Lakhsmi Putri Indri , Islami Kusuma , Fitri Aisyah Imaniar , Pramanasari Rachmaniar , Kencono Wungu Citrawati Dyah 
Published: January 2025

Objective This study compares mandibular distraction osteogenesis (MDO) and tracheostomy in managing severe airway obstruction in patients with the Pierre Robin sequence (PRS). Design A systematic review and meta-analysis following PRISMA guidelines was performed. Literature searches were conducted across PubMed, ScienceDirect, Cochrane Library, Scopus, E.B.S.C.O., and Web of Science, including grey literature, covering studies until May 30, 2024. Study quality was assessed using the Newcastle-Ottawa Scale. Patients patients with Pierre Robin Sequence. Interventions Mandibular distraction osteogenesis (MDO) and tracheostomy. Main Outcome Measures Primary outcomes included airway management (tracheostomy avoidance for MDO, decannulation for tracheostomy) and feeding outcomes (G-tube placement). Secondary outcomes were hospital length of stay and associated costs. Results Thirteen studies were included. MDO and the MDO-first approach demonstrated significantly better airway outcomes (OR = 10.72, 95% CI = 1.97–58.44, p = 0.006; OR = 4.51, 95% CI = 2.61–7.79, p < 0.00001). MDO also reduced the need for G-tube placement (OR = 0.09, 95% CI = 0.04–0.18, p < 0.00001) and lowered hospital costs (MD = -47.90 thousand USD, 95% CI = -59.93 to −35.87, p < 0.0001). A shorter hospital stay was observed but was not statistically significant. Conclusions MDO offers better airway outcomes, lower G-tube placement rates, and reduced costs, making it a preferred option. Larger studies within the same syndromic status are needed to minimize confounding factors and validate these findings.
The effects of transcranial direct current stimulation on global cognition in patients with Alzheimer's disease: An update meta-analysis
Authors: Su Siyuan , Huang Ruihan , Liu Yongsheng 
Published: January 2025

Background Alzheimer's disease (AD) is a neurodegenerative disease. At present, there are currently no drugs that can cure AD. Objective A number of empirical studies have shown that transcranial direct current stimulation (tDCS) may be used to treat cognitive abnormalities in patients with AD. We will through meta-analysis reviews tDCS overall research on the effects of cognitive function in patients with AD. Methods Systematic searches were performed in the PubMed, Embase, and Cochrane Library databases from their creation until 8 March 2024. Using a fixed effect model and random effect model to evaluate the average difference between the treatment group and control group (MD) and its 95% confidence interval (CI). Results The study included 10 randomized controlled trials (Nactive = 165, Nsham = 167). The results of the overall analysis showed that tDCS did not significantly improve the overall cognitive function (SMD = 0.17; 95%CI = −0.05, 0.39; p = 0.14; I² = 51%). Quality of life of AD patients after treatment was also evaluated, but no improvement was seen. Subgroup analysis showed no significant improvement in global cognitive function after tDCS treatment. The sensitivity analysis to confirm the reliability of the data, risk assessment did not find any high-risk projects. Conclusions The tDCS treatment did not improve cognitive function in patients with AD. Further empirical research in the future will help to explore new schemes for tDCS to improve cognitive function of patients.
Treatment of anterior rim fractures of the distal radius with an anterior rim plate: A retrospective study
Authors: Chen Kuan-Po , Chen I-Chien , Wu Chin-Hsien , Tseng Tzu-Ming , Ma Ching-Hou , Tu Yuan-Kun 
Published: January 2025

Treatment of distal radial fractures that include small anterior rim fragments can be difficult. We retrospectively reviewed 19 patients in whom an anterior rim plate with locking screws was used. After a median follow-up of 18 months (range 6–32; interquartile range (IQR) 14, 26), the median wrist flexion and extension arc was 70° (range 50–80; IQR 60, 70), the median grip strength was 80% of the contralateral side (range 52–104; IQR 77, 88), the median visual analogue scale score for pain was 0 (range 0–5; IQR 0, 1), the median disabilities of the arm, shoulder and hand score was 2 (range 0–59; IQR 0, 11) and the median modified Mayo wrist score was 80 (range 35–100; IQR 75, 85). Two patients exhibited loss of reduction; one was treated conservatively and the other underwent revision surgery. Our findings support anterior rim plates as a treatment option for anterior rim fractures if they are properly placed. Level of evidence: IV
Effectiveness and safety of oral vancomycin for the treatment of inflammatory bowel disease associated with primary sclerosing cholangitis: a systematic review and pooled analysis
Authors: Sannaa Wassel , Almasry Mazen , Peedikayil Mustafa , Grimshaw Alyssa A. , Attamimi Mashary , AlMutairdi Abdulelah , Al-Bawardy Badr 
Published: January 2025

Background: Inflammatory bowel disease (IBD) occurs in up to 70%–80% of patients with primary sclerosing cholangitis (PSC). Oral vancomycin therapy (OVT) has been reported to be effective in the treatment of IBD associated with PSC (IBD-PSC). Objectives: To examine the effectiveness and safety of OVT in the treatment of IBD-PSC by performing a systematic review and pooled analysis of the literature. Design: We performed a systematic review and pooled analysis of studies reporting IBD clinical response to OVT in IBD-PSC. Data sources and methods: A systematic search was conducted in Cochrane Library, Embase, Google Scholar, Medline, PubMed, Scopus, and Web of Science from database inception to June 3, 2024. We included adult and pediatric studies that reported on clinical response (defined as any improvement in IBD-related clinical symptoms) of IBD-PSC patients treated with OVT (including pre- and post-liver transplantation cohorts). Pooled analyses of OVT response and safety were performed. Results: A total of 21 (open-label, non-controlled) studies including 290 patients with IBD-PSC treated with OVT were included. The median duration of OVT to treat IBD-PSC was 32.5 weeks (interquartile range (IQR): 19–83 weeks). The total daily dose of OVT ranged from 250 to 1500 mg. Concomitant treatment included the following: mesalamine in 14.5% ( n = 42), advanced therapies in 10.7% ( n = 31), and immunosuppressive agents in 14.1% ( n = 41). Clinical response was noted in 47.6% (138/290) and clinical remission in 43.5% (100/230). The biochemical remission rate post-OVT was 68.8% (55/80) and endoscopic remission was 39.4% (80/203). Three studies ( n = 11) reported no episodes of acute cholangitis while on OVT. Five studies ( n = 69) reported an incidence rate of 8.7% of vancomycin-resistant enterococci post-OVT to treat IBD-PSC. Conclusion: OVT was associated with clinical response/remission in almost half of patients with IBD-PSC with a favorable side effect profile. Further prospective randomized trials are needed to confirm the dosing, efficacy, treatment duration, and long-term safety of OVT for the treatment of IBD-PSC. Trial registration: The study protocol was registered with PROSPERO a priori (no. CRD42023438341).
Discovery of Active Ingredients Oleanolic Acid, Ursolic Acid, and Arbutin for in Vitro Anti-Melanoma: Network Pharmacology and Experimental Validation
Authors: Ma Junjie , Wang Jihong , Tao Yang , Zeng Guangzhi , Yang Xingyan , Lai Qi 
Published: January 2025

Objective Antitumor effects of the medicinal herb Prinsepia utilis Royle ( P. utilis) have been reported. This study aimed to identify the potential functional components and molecular mechanisms of P. utilis in the treatment of melanoma through network pharmacology and experimental verification. Methods Bioinformatics database and pharmacology analysis platform of the Chinese medicine system were used to obtain the active components of P. utilis, and the potential targets were predicted by the Swiss Target Prediction database. Disease targets associated with melanoma were retrieved from the Genecard database. Network topology analysis and functional enrichment analysis were conducted to screen out the core targets and related signal pathways. The molecular docking method was employed to evaluate the core target binding to bioactive ingredients of P. utilis, and a molecular biology experimental approach was performed to predict and verify the potential molecular mechanism of P. utilis in treating melanoma. Results KEGG pathway analysis revealed the enrichment of multiple cancer-related pathways and signaling pathways. Oleanolic acid (OA), Ursolic acid (UA), Arbutin are the active ingredients of P. utilis. The crude extract of P. utilis was able to inhibit melanin in A375 cells. The active compounds OA and UA in P. utilis can significantly inhibit the growth and migration ability of human melanoma cells A375 while inducing apoptosis and inhibiting tyrosinase activity and melanin synthesis. In contrast, arbutin does not show obvious performance in these biological activities. Conclusion These findings suggest that OA and UA are promising as more effective anti-melanoma active ingredients in P. utilis. In conclusion, these studies suggest that OA and UA can protect against melanoma by regulating tyrosine to inhibit melanogenesis.
De novo thyroid eye disease following COVID vaccination several years after radioiodine therapy
Authors: Mukunda Athira , James Jovito , Jacob Rhea , Varughese George I , Nayak Ananth U 
Published: January 2025

Lesson The delayed onset of thyroid eye disease is well recognised but less commonly perceived in routine clinical practice and this case report serves as a reminder for a high index of suspicion in at-risk patients.
Dissemination through trusted credible messengers: 133 weeks of the Flint Community Webinar on COVID-19
Authors: Uphold Heatherlun , Lewis E. Yvonne , Drahota Amy , Warren Blair , Edwards-Johnson Jennifer , Crawford Mary Katherine , Sadler Richard , Woolford Susan J. , Ellington Roni , Zimmerman Marc , Grodzinski Alison , Furr-Holden C. Debra 
Published: January 2025

Background Community access to evidence-based information is critical, especially during a pandemic, as it can impact knowledge and adoption of health behaviors that affect health disparities. The field of dissemination and implementation (D&I) science is ideally positioned to address this need through its focus on reducing the research-to-practice gap through improved distribution of information. The purpose of this paper is to describe the creation of a weekly webinar series about COVID-19 directed toward community members, and the extent to which webinars were found useful and increased awareness of evidence-based information and services. Lessons learned about this dissemination strategy as well as the selection and involvement of trusted credible messengers (TCMs) to share information are discussed. Method Data were derived from Zoom attendance reports, YouTube views, and survey responses collected about the weekly webinar series over 133 weeks from March 20, 2020 through September 30, 2022. Results The webinar reached a minimum of 877 unique within-webinar participants, representing more than 9,190 in-webinar participant hours and an additional 17,303 YouTube views. A consistent base of weekly attendees (e.g., service providers, community members) reported increasing levels of satisfaction and utility over time. Conclusions This study supports the use of a community webinar series to disseminate evidence-based, locally relevant information through TCMs to improve community access to knowledge of health information and resource utility.