bluuebunny/crossref_metadata_2025_split huggingface dataset:
Esthesioneuroblastoma: an institutional based descriptive study of a rare tumor
Authors: Vasudevan Geetha , Parampalli Srinivas Srilatha , Jaiprakash Padmapriya , Pujary Kailesh 
Published: July 2023

Background: Esthesioneuroblastoma is a slow-growing rare malignant neuroectodermal tumor arising from the olfactory epithelium. It has a bimodal incidence with peaks in the second and third decades of life and the sixth and seventh decades of life with equal incidence among men and women. Prognostic factors include the Hyams grade and modified Kadish stage. This study analyzed the clinicopathological features of esthesioneuroblastoma.
Materials and methods- Retrospective study of patients who were diagnosed with esthesioneuroblastoma at a tertiary care hospital between January 2012 and May 2019 was conducted. The research was performed according to the World Medical Association Declaration of Helsinki. Institutional research committee approval (IEC: 473/2019) was obtained.
Results: Clinicopathological profiles of 8 patients who were diagnosed with esthesioneuroblastoma during the period were included. Among the eight patients, five were female and three were male. Common presenting complaints were nasal obstruction, difficulty in breathing, epistaxis, local pain, and anosmia. The average age of presentation was 52 years, ranging from 14 to 73 years. Anterior rhinoscopic examination in these cases showed a polypoid mass located in the nasal cavity. According to the Hyams grading system, three of the eight cases were grade-2 and the remaining five cases were grade-3 Hyams histological grade. Three cases exhibited foci of ganglioneuroblastic transformation. Three patients had metastases to cervical lymph nodes and three patients had recurrence.
Conclusions: Esthesioneuroblastoma is a rare aggressive malignant tumor. It can exhibit divergent epithelial or ganglionic differentiation. A proper diagnosis should be made, graded and staged before proceeding to treatment.
Platelet count and platelet indices in patients of pregnancy-induced hypertension at a rural tertiary care hospital in western India
Authors: Mangala Nagare , Shaikh Alisha , Dangare Harsha 
Published: July 2023

Background: Pregnancy-induced hypertension is a serious complication during pregnancy causing maternal and fetal morbidity and mortality. Pregnancy-induced hypertension associated with thrombocytopenia can help in predicting the severity of the disease. The study aimed to study the platelet count, and platelet indices in Pregnancy induced hypertension patients and compare them with normotensive pregnant women.
Materials and methods: This was a case control study, conducted on patients visiting antenatal care (ANC) at a Tertiary care rural hospital in western India. Study population included a total of 82 patients, which were divided into 2 groups with 41 patients in each control (healthy pregnant women) and study groups (pregnant women with PIH). Patients with chronic hypertension and known case of thrombocytopenia were excluded from the study. The blood samples collected were processed on fully automated cell counter for estimation of platelet count and indices.
Results: The platelet count in the study group ranged from 186434.1±81086.9 whereas in the control group it was 268659±72206.9, showing that the platelet count was significantly lower in women with Pregnancy induced hypertension than in the control group. The MPV, PDW, systolic BP, diastolic BP was found to be significantly elevated in the study group as compared to the control group.
Conclusions: The present study concludes that blood parameter such as platelets count and platelet indices can be considered as an early, economical and easily available parameter for assessment of severity of PIH cases.
Gambaran Kualitas Layanan Kesehatan di Puskesmas Ngemplak Simongan
Authors: Putri Rita Amelia , Kusumo Wahyu Eko Giri , Desty Rani Tiara 
Published: July 2023

Service quality is one measure to assess public services. Public service is an activity or a series of activities in the context of fulfilling service needs in accordance with statutory regulations for every citizen and resident for goods, services and/or administrative services provided by public service providers. The state is obliged to serve every citizen and resident to fulfill their basic rights and needs within the framework of public services which are mandated by the 1945 Constitution. The Ngemplak Simongan Health Center is the first level implementing unit in providing health services in its working area, namely the village level. The purpose of this study was to see the extent to which the quality of health services at the Ngemplak Simongan Health Center was satisfied by looking at the elements of safety, effectiveness, patient-centered, timely, efficiency, fairness. The method used in this research is purposive sampling. The results showed that the health services at the Ngemplak Simongan Health Center were quite good, but there were still some that were lacking at this Health Center. It is hoped that the facilities and infrastructure available at the Ngemplak Simongan Health Center can improve the performance and quality of services provided. It is hoped that the Ngemplak Simongan Health Center can be better in providing services in the future by seeing that there is still dissatisfaction with health service users at the Ngemplak Simongan Health Center.
Erholung in siedlungsnahen Wäldern – gestern, heute und in Zukunft
Authors: Karn Susanne 
Published: July 2023

Abstract
Siedlungsnahe Wälder gehören zu den beliebtesten Naherholungsräumen und werden für Freizeitaktivitäten stark genutzt. Die Infrastruktur im Wald könnte jedoch verbessert und noch wirksamer für den Menschen gestaltet werden. Oftmals könnte mit wenigen Mitteln ein spürbarer Beitrag für die psychische und physische Gesundheit aller Waldnutzerinnen und -nutzer geleistet werden. In einer hier vorgestellten Publikation werden beispielhaft konkrete Massnahmen zur Verbesserung der Erholungsqualitäten im Wald aufgezeigt. Eine Toolbox unterstützt die Arbeit an der Erholungsplanung, und es werden Handlungsempfehlungen für den Planungsprozess gegeben. Beispielhafte Erholungswälder zeigen, welchen besonderen Wert sie für die Bevölkerung haben können, wenn verschiedene Aspekte genügend berücksichtigt sind.
Wer will schon astiges und krummes Rundholz?
Authors: Maurer Philipp 
Published: July 2023

Abstract
Erholung im Wald lebt von Sinneseindrücken. Gewisse Waldbilder und Wuchsformen faszinieren mehr als andere. Über gezielte gestalterische Eingriffe können wir mit Waldbau für Erholung ein gewünschtes Zielbild erreichen, analog dem Wirtschaftswald. Daraus lässt sich ein Geschäftsmodell mit Produkten und Bestellern ableiten. Auf der Bewirtschafterseite verlangt das Geschäftsmodell aber glaubwürdige Fachkompetenz, die heute im Bereich der Erholung erst ungenügend vorhanden ist.
Pengembangan Media Pembelajaran E-Booklet Virus Corona (Covid-19) sebagai Sumber Edukasi untuk Siswa SMA
Authors: Susilo Eko , Dewi Asih Fitriana 
Published: July 2023

Peristiwa pandemi virus corona (Covid-19) di Indonesia menyebabkan banyak perubahan, bahkan dalam kehidupan sehari-hari. Perubahan perilaku yang kondusif terhadap pencegahan virus corona (Covid-19) hendaknya didasari dari pemahaman masyarakat termasuk siswa di sekolah terutama terkait pencegahan penularannya. Sebagian besar Siswa SMA Negeri 1 Raman Utara menyatakan kurangnya kedisiplinan dalam menerapkan protokol kesehatan covid-19 dalam kehidupan sehari-hari, kurangnya pengetahuan dan pemahaman tentang virus corona (Covid-19), dan belum adanya media yang digunakan guru untuk mengedukasi pencegahan virus corona (Covid-19) sehingga siswa belum mendapatkan edukasi dalam pembelajaran yang optimal berkaitan infeksi virus corona (Covid-19) dan pencegahannya. Adapun Tujuan penelitian ini adalah (1) untuk mengembangkan media pembelajaran e-booklet virus crona (covid-19), (2) untuk menganalisis kelayakan media pembelajaran e-booklet virus crona (covid-19), dan (3) untuk menganalisis respon guru dan siswa terhadap media pembelajaran e-booklet virus crona (Covid-19) sebagai sumber edukasi untuk siswa SMA. Penelitian ini menggunakan metode Research and Development dengan model 4D dilakukan dengan tahap define (pendefinisian), tahap design (perencanaan), tahap develop (pengembangan) dan tahap disseminate (penyebaran). Penelitian ini hanya dibatasi sampai pada tahap develop (pengembangan) hal ini dikarenakan dalam penelitian ini tidak bertujuan untuk mengetahui seberapa jauh efektivitas kegiatan pembelajaran yang dikembangkan. Hasil penelitian yang telah dilakukan diantaranya sebagai berikut; hasil validasi ahli materi sebesar 92% dengan kategori “sangat layak”, hasil validasi ahli media sebesar 91% dengan kategori “sangat layak”. Penilaian respon guru memperoleh hasil sebesar 90% dengan kategori “sangat layak” dan penilaian respon 15 siswa memperoleh hasil skor sebesar 90% dengan kategori “sangat layak”. Sehingga hasil tersebut menunjukkan bahwa E-Booklet virus corona (Covid-19) yang dikembangkan layak dan dapat digunakan sebagai sumber edukasi untuk siswa SMA.
Non-payments in the Russian economy in the 1990s: An unforeseen institution
Authors: Chubais A. B. 
Published: July 2023

Among the large-scale processes that caused the greatest damage to the Russian economy and population in the 1990s and significantly undermined the prestige of the reformers, non-payments occupied a special place. To minimize their negative impact, long-time efforts were made by the government, the presidential administration and business (the author of this article had to actively participate in this). The article describes the scale, depth and duration of this phenomenon, analyzes the descriptions of its causes and ways to overcome it presented in the scientific literature, proposes the author’s understanding of the causes and real mechanisms of solution, formulates additions to the original concept of reform developed by a group of Moscow and Leningrad scientists in the second half of the 1980-x.
The house that Keynes built: Redecorating and overhaul of the monetary policy model
Authors: Moiseev S. R. 
Published: July 2023

The regular economic crisis prompts macroeconomists to revise their models. The monetary policy is no exception. As a result of the “Great Recession” in 2007-2009 and the COVID-­19 pandemic in 2020-2021, they were forced to refresh a look at the monetary policy models that define central bank’s short­term interest rate decisions. The principles of the New Keynesian economics lie behind most modern models of monetary policy. A set of equations based on several theoretical assumptions and simplifications leads to certain model conclusions. An active work to review the New Keynesian models in the 2020s is under way. Key improvements include financial sector modeling; replacing rational expectations with their alternatives, as well as representative economic agents with heterogeneous ones; finding microeconomic foundations for assumptions; and fiscal policy modeling.
A Literature Review on the Application of IRB Chairperson Guidelines 4: "Women Refugee Claimants Fearing Gender-Related Persecution" in Decision Making
Authors: Bah Haby 
Published: July 2023

<p>This paper examines Canada's "Women Refugee Claimants Fearing Gender-Related Persecution" and its implications on women asylum seekers in Canada. Canada's Women Refugee Claimants Fearing Gender-Related Persecution Guidelines were examined in order to get a better understanding of its impact on women seeking protection from gender based persecution. The first section of this paper looks at how certain refugee policies such as the Designated Country of Origin List and the Internal Flight Alternative have impacted women fleeing gender based persecution while the second</p>
<p>section discusses the implications of the guidelines on women asylum seekers refugee determination process. This paper provides background information on some of the unique forms of persecution that are specific to women and discusses the lack of women's issues within international refugee law. Lastly, this paper provides ways in which the guidelines can be improved to better support women fleeing gender based persecution.</p>
Yenilebilir Peyzajlar: Meyvesi Yenilebilen Bitki Türlerinin Peyzaj Mimarlığı Uygulamalarında Kullanma Uygunluğu
Authors: AK Tutku , GÜNEŞ Zehra 
Published: July 2023

Günümüzde geleneksel olarak yapılan peyzaj düzenlemelerinde çoğu kez meyvesi yenilebilen bitkilere yer verilirken, peyzaj mimarlarının yaptığı uygulmalarda daha çok süs bitkileri tercih edilmektedir. Bu araştırmanın amacı, yenilebelir peyzajlar kavramını tanıtarak, peyzaj mimarlarının yaptıkları düzenlmelerde meyvesi yenilen bitki türlerine yer vermesini sağlamaktır.
Bu amaç doğrultusunda, bu araştırmada meyvesi yenilebilen bitkilerin estetik ve fonksiyonel işlevleri değerlendirilerek, peyzaj mimarlığında kullanılabilirliği konunun uzmanlarınca belirlenmeye çalışılmıştır. Türkiye’de sıkça kullanılan 54 meyveli türe yer verilmiş, bu türlerin estetik ve fonksiyonel açıdan peyzaj mimarlığında kullanımlarının uygunluğunu saptanmaya çalışımıştır.
Araştırma sonucunda meyvesi yenebilen bazı bitki türlerinin estetik anlamda peyzaj mimarlığında kullanıma çok uygun olduğu, ancak fonsiyonel anlamda kullanıma kısmen uygun olduğu bulunmuştur. Bu bitkilerden hem estetik hem de fonksiyonel olarak peyzaj mimarlığında kullanıma uygun olanlar ise araştırma sonucunda belirlenmiştir.
METAMORFOSES DO CIRCUITO INFERIOR RESIDENCIAL: UMA ANÁLISE DA DINÂMICA COMERCIAL DO BAIRRO TRÊS IRMÃS, CAMPINA GRANDE-PB (2017-2018)
Authors: Pereira Davidson Matheus Félix , Diniz Lincoln da Silva , Costa Gustavo dos Santos 
Published: July 2023

O presente texto corresponde a algumas reflexões sobre o processo de segregação socioespacial e sua relação com a dinamização comercial nas periferias urbanas com o objetivo de compreender a dinâmica socioespacial da Feira Sudoeste no bairro Três Irmãs, Campina Grande. Para tanto, identificamos os principais fatores que resultaram na criação desta feira, bem como sua função na localidade, considerando a circulação de consumidores, comerciantes, mercadorias e capitais. Como opção teórico-metodológica, adotamos os conceitos de "circuito inferior residencial" e "circuito inferior central" trabalhados por Milton Santos em sua obra "O Espaço Dividido", isso nos possibilitou analisar as diferenças entre a dinâmica dos comércios periféricos com relação aos comércios ligados ao centro da cidade. Para tanto, utilizamos uma metodologia quali-quantitativa, pautada na pesquisa in loco, apropriando-se da aplicação de entrevistas semiestruturadas, de questionários estruturados, bem como, da captura de imagens fotográficas. De tal maneira, ao final da pesquisa constatamos que a respectiva feira exercia um importante papel na dinamização econômica do mencionado bairro, ofertando í s camadas mais pobres da população possibilidades de emprego e de consumo de produtos perecí­veis a baixo custo. Pode-se observar uma real estratificação socioespacial nessa área periférica, com a existência de moradores com diferentes possibilidades de acesso aos mercados localizados no centro da cidade.
Visualization of automatically combined disease maps and pathway diagrams for rare diseases
Authors: Gawron Piotr , Hoksza David , Piñero Janet , Peña-Chilet Maria , Esteban-Medina Marina , Fernandez-Rueda Jose Luis , Colonna Vincenza , Smula Ewa , Heirendt Laurent , Ancien François , Groues Valentin , Satagopam Venkata P. , Schneider Reinhard , Dopazo Joaquin , Furlong Laura I. , Ostaszewski Marek 
Published: July 2023

Introduction: Investigation of molecular mechanisms of human disorders, especially rare diseases, require exploration of various knowledge repositories for building precise hypotheses and complex data interpretation. Recently, increasingly more resources offer diagrammatic representation of such mechanisms, including disease-dedicated schematics in pathway databases and disease maps. However, collection of knowledge across them is challenging, especially for research projects with limited manpower.Methods: In this article we present an automated workflow for construction of maps of molecular mechanisms for rare diseases. The workflow requires a standardized definition of a disease using Orphanet or HPO identifiers to collect relevant genes and variants, and to assemble a functional, visual repository of related mechanisms, including data overlays. The diagrams composing the final map are unified to a common systems biology format from CellDesigner SBML, GPML and SBML+layout+render. The constructed resource contains disease-relevant genes and variants as data overlays for immediate visual exploration, including embedded genetic variant browser and protein structure viewer.Results: We demonstrate the functionality of our workflow on two examples of rare diseases: Kawasaki disease and retinitis pigmentosa. Two maps are constructed based on their corresponding identifiers. Moreover, for the retinitis pigmentosa use-case, we include a list of differentially expressed genes to demonstrate how to tailor the workflow using omics datasets.Discussion: In summary, our work allows for an ad-hoc construction of molecular diagrams combined from different sources, preserving their layout and graphical style, but integrating them into a single resource. This allows to reduce time consuming tasks of prototyping of a molecular disease map, enabling visual exploration, hypothesis building, data visualization and further refinement. The code of the workflow is open and accessible at https://gitlab.lcsb.uni.lu/minerva/automap/.
Can we achieve biomimetic electrospun scaffolds with gelatin alone?
Authors: Roldán Elisa , Reeves Neil D. , Cooper Glen , Andrews Kirstie 
Published: July 2023

Introduction: Gelatin is a natural polymer commonly used in biomedical applications in combination with other materials due to its high biocompatibility, biodegradability, and similarity to collagen, principal protein of the extracellular matrix (ECM). The aim of this study was to evaluate the suitability of gelatin as the sole material to manufacture tissue engineering scaffolds by electrospinning.Methods: Gelatin was electrospun in nine different concentrations onto a rotating collector and the resulting scaffold’s mechanical properties, morphology and topography were assessed using mechanical testing, scanning electron microscopy and white light interferometry, respectively. After characterizing the scaffolds, the effects of the concentration of the solvents and crosslinking agent were statistically evaluated with multivariate analysis of variance and linear regressions.Results: Fiber diameter and inter-fiber separation increased significantly when the concentration of the solvents, acetic acid (HAc) and dimethyl sulfoxide (DMSO), increased. The roughness of the scaffolds decreased as the concentration of dimethyl sulfoxide increased. The mechanical properties were significantly affected by the DMSO concentration. Immersed crosslinked scaffolds did not degrade until day 28. The manufactured gelatin-based electrospun scaffolds presented comparable mechanical properties to many human tissues such as trabecular bone, gingiva, nasal periosteum, oesophagus and liver tissue.Discussion: This study revealed for the first time that biomimetic electrospun scaffolds with gelatin alone can be produced for a significant number of human tissues by appropriately setting up the levels of factors and their interactions. These findings also extend statistical relationships to a form that would be an excellent starting point for future research that could optimize factors and interactions using both traditional statistics and machine learning techniques to further develop specific human tissue.
Comparative analysis of the sustainability and seismic performance of a social interest house using RC moment frames and bahareque as structural systems
Authors: Tello-Ayala Ken , Garcia-Troncoso Natividad , Silva Christian E. , Zúñiga-Olvera Carlos , Narvaez-Moran Julio , Malaga-Chuquitaype Christian , Mouka Theodora 
Published: July 2023

This study compares the seismic performance and environmental impact of a social housing structure designed with reinforced concrete with a structure using Guadua angustifolia “Kunth” cane. The aim is to contrast the implementation of an ecological material such as the Guadua cane, which is an accessible alternative due to its cost and construction time, versus the traditional reinforced concrete (RC) construction method. Both applied to social housing structures. The seismic performance of both methods is analyzed through nonlinear static analysis (pushover) with the objective of establishing the performance; structural and nonstructural damage, performance point, maximum displacements, and structural elements that induce structural failure; and acting forces, against a design earthquake (established by the NEC DS 2015 Standard), with a return period of 475 years. The environmental impact is evaluated through a life cycle assessment of the structure (LCA). Thus, the embodied carbon obtained from each structural element (foundations, beams, columns, floors, and roof support elements) was determined, considering material manufacturing, transportation, and construction. The results obtained demonstrated a higher seismic performance, with 70% less environmental impact on the Guadua cane structure.
AAV2 and AAV9 tropism and transgene expression in the mouse eye and major tissues after intravitreal and subretinal delivery
Authors: Koponen Sanna , Kokki Emmi , Tamminen Toni , Ylä-Herttuala Seppo 
Published: July 2023

Introduction: The eye is an excellent target for gene therapy because of its anatomical features. Gene therapy to treat ocular disorders relies on efficient gene delivery and transgene expression in the target cells. The aim of this study was to compare the biodistribution and safety of two different AAV serotypes after intravitreal (IVT) and subretinal injections.Methods: AAV2 (1 × 1012 vg/mL) and AAV9 (5 × 1012 vg/mL) vectors expressing an enhanced green fluorescent protein (EGFP) and an AAV9-empty (6 × 1011 vg/mL) vector were injected intravitreally or subretinally into both eyes of adult C57Bl/OlaHsd mice. The biodistribution of the viral vectors in the eye and off-target tissues was studied using qPCR. GFP expression was studied from cryosections, and GFP transduction efficacy was verified using immunohistostaining for GFP. In addition, electroretinography (ERG) was used to assess the effect of vectors on retinal function.Results: In addition to the eyes, viral vector copies were found in distant off-target tissues such as the liver, especially after AAV9-EGFP IVT and subretinal injections. AAV9-EGFP injections showed more GFP expression throughout the retina compared to AAV2-EGFP. AAV2-EGFP IVT showed transgene expression mainly in the ganglion cell layer, whereas subretinal injection showed GFP expression in the retinal pigment epithelium. In addition, GFP was expressed at a moderate level in the liver after both injection routes of AAV9 and in parts of the brain after all injection groups except AAV9-empty. Lowered a- and b-amplitude values were seen in ERG in both scotopic and photopic experiments after AAV9-EGFP subretinal injection compared to all other groups.Discussion: This study shows that intraocular injection of AAV2 and AAV9 transduces retinal cells. Although the more efficient transduction of the retina, negative effect on the retinal function, and off-target transgene expression of AAV9 makes AAV2 a more suitable gene delivery vector to treat ocular disorders.