bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal ℓ1-robust tracking for autoregressive plant with unknown nominal model
Authors: Sokolov V. 
Published: September 2023

This paper addresses the problem of adaptive optimal robust
tracking for a discrete-time plant with unknown parameters
of autoregressive nominal model and unknown bias of
bounded external disturbance. Upper bounds of unbiased external
disturbance and gains of uncertainties in output and
control are assumed to be know. The optimal tracking problem
is to minimize the guaranteed worst-case steady-state
upper bound of the tracking error for a given bounded reference
signal. Solution of the problem is based on optimal
set-membership estimation of unknown non-identifiable parameters
and treating the control criterion as the identification
criterion. Optimal on-line set-membership estimation
becomes computationally tractable due to a linear-fractional
representation of the control criterion.
Massless Stueckelberg particle, solutions with cylindric symmetry
Authors: Semenyuk O. , Pletyuhov V. , Buryy A. , Ivashkevich A. , Red'kov V. 
Published: September 2023

The massless Stueckelberg field is studied in cylindrical coordinates.
The field function consists of the scalar, 4-vector,
and antisymmetric tensor. Physically observable components
are the scalar and 4-vector. We apply the Stueckelberg
tetrad-based matrix equation, generalized to arbitrary Riemannian
space, including any curvilinear coordinates in the
Minkowski space. We construct solutions with cylindric symmetry,
while the operators of energy, of the third projection
of the total angular momentum, and the third projection of
the linear momentum are diagonalized. After separating the
variables we derive the system of 11 first-order differential
equations in polar coordinate. It is solved with the use of the
Fedorov–Gronskiy method. According to this method, all 11
functions are expressed through 3 main funcions. According
to the known procedure we impose the differential constraints,
which are consistent with the all 11 equations and
allow us to transform these equations to algebraic form. This
algebraic system is solved by standard methods. As a result,
we obtain 5 linearly independent solutions. The problem of
eliminating the gauge solutions will be studied in a separate
paper.
Efecto de la hemodiálisis de alto flujo en la dosis de eritropoyetina en pacientes con enfermedad renal crónica
Authors: Aguilar-Rodríguez Ana , Hinostroza-Yanahuaya Julie , Lopera-Quintanilla María T. 
Published: September 2023

Objetivo: Evaluar el requerimiento de eritropoyetina (EPO) tras el cambio de membrana de bajo a alto flujo en pacientes prevalentes en hemodiálisis. Secundariamente determinar la variación de β2-microglobulina, Proteína C reactiva (PCR) y ferritina. Material y métodos: Estudio retrospectivo observacional en pacientes prevalentes en hemodiálisis en dos centros de diálisis en Perú. Se determinaron las características clínicas y demográficas de los pacientes. Se determinó hemoglobina, porcentaje de saturación de transferrina, ferritina, Kt/V y dosis de EPO basal y cada 3 meses durante los 12 meses posteriores al cambio de dializador. Adicionalmente se determinó la PCR y β2-microglobulina a los 3, 6 y 12 meses. Resultados: Se incluyeron 58 pacientes que cumplieron con los criterios de inclusión y exclusión. La dosis de EPO basal fue 5 763,55 ± 3 000,69 UI/semana y a los 12 meses, 4031,18 ± 2 663,95 UI/semana (p=0,000) y la hemoglobina basal 11,10 ± 1,24 g/dl y a los 12 meses 11,69 ± 1,28 g/dl (p=0, 077). La β2-microglobulina disminuyó de 45,64 ± 11,39 mg/l a 26,26 ± 8,02 mg/l a los 12 meses (p=0,000). Conclusiones: En la población de estudio la dosis de EPO disminuyó 30% a los 12 meses sin cambios en la hemoglobina. La β2-microglobulina disminuyó 42,5% al año.
Condicionantes para la participación laboral de las personas con discapacidad por lesión medular atendidas en un instituto especializado de rehabilitación
Authors: Casallo Castilla Carmen Natividad 
Published: September 2023

Objetivo: Determinar los factores condicionantes para la participación laboral de las personas con discapacidad por lesión medular de un instituto especializado de rehabilitación. Material y métodos: Estudio observacional, retrospectivo y relacional; se incluyeron 224 pacientes con lesión medular del Departamento de Investigación, Docencia, y Atención en Ayuda al Tratamiento del Servicio de Rehabilitación Profesional que fueron atendidos en el periodo 2016 al 2019. Se recolectaron variables clínicas, sociodemográficas y contextuales; y la actividad económica antes y después de la lesión. Resultados: El 65 % de pacientes fueron del sexo masculino, de edad media de 38,61 ± 13,33; según el nivel de lesión medular el 85,3% de pacientes tenía paraplejia, el 62,5% con grado de lesión en la escala ASIA A; el tiempo de evolución fue de más de 1 año 30,4%, estado civil soltero 52,2%, de procedencia Lima y provincias el 51,3%, con grado de instrucción de secundaria 50,9%, nivel socioeconómico de pobreza extrema en 61%. Se encontró diferencia significativa entre la participación laboral antes de la LM y el sexo (p<0,01) y la condición laboral (p<0,0069). La participación laboral después de la LM tuvo una diferencia significativa con el nivel socioeconómico (p<0.005) y el grado de lesión en la escala ASIA (p<0,014). El análisis de regresión logística mostró que el único factor asociado con la participación laboral fue el tiempo transcurrido de la lesión medular (p=0,039; OR=19,9). Conclusiones: Los pacientes con LM con menores ingresos económicos ubicados en grupos de pobreza pobre extremo y no extremo tuvieron mayor participación laboral; así como los que tuvieron un mayor grado de lesión en la escala ASIA. Asimismo, el único factor predictor de la participación laboral fue el tiempo transcurrido desde la lesión.
Meningkatkan Kemampuan Apresiasi Tari Traditional Dengan Model Pembelajaran Case Based Learning
Authors: Prihanita Kusuma Wardani  , Ojang Cahyadi  , Elindra Yetti  
Published: September 2023

Tari Tradisional merupakan salah satu kesenian yang harus dilestarikan, dalam mempelajari kesenian, terdapat nilai nilai sosial budaya, moral, dan nilai keindahan yang patut untuk diapresiasikan. Tari tradisional menjadi penting untuk diapresiasi karena selain mengandung nilai keindahan, didalamnya juga mengandung nilai kesehatan, pesan moral, cerita, serta nasihat. Kemampuan apresiasi sangat penting dimiliki oleh peserta didik supaya dapat meningkatkan rasa ingin melestarikan dan bangga akan kebudayaannya. Penelitian ini bertujuan untuk meningkatkan kemampuan apresiasi siswa terhadap tari tradisional melalui penerapan model pembelajaran case based learning. Penelitian ini merupakan penelitian tindakan kelas dengan model Kemmis dan Mc Taggart, menggunakan analisis kuantitatif statistik dan kualitatif deskriptif. Teknik pengumpulan data melalui observasi, wawancara, tes dan dokumentasi pada siswa kelas X IPA 6 SMA Negeri 2 Depok. Penelitian ini dilakukan dalam II siklus sejumlah 38 siswa, pengambilan data dilakukan pada Siklus I dan Siklus II. Hasil dari penelitian ini terlihat adanya peningkatan pada data pra siklus dengan rata rata 69,7 dan meningkat pada siklus I dengan rata rata 75,3 dan meningkat pada siklus II dengan rata rata 89,32 dengan ketuntasan pada siklus I sebesar 50% dan siklus 2 sebesar 99%, yang berarti terdapat peningkatan terhadap hasil proses pembelajaran apresiasi tari tradisional dengan model pembelajaran case based learning.
Design and Implementation of a National Program to Monitor the Prevalence of SARS-CoV-2 IgG Antibodies in England Using Self-Testing: The REACT-2 Study
Authors: Ward Helen , Atchison Christina , Whitaker Matthew , Davies Bethan , Ashby Deborah , Darzi Ara , Chadeau-Hyam Marc , Riley Steven , Donnelly Christl A. , Barclay Wendy , Cooke Graham S. , Elliott Paul 
Published: September 2023

Data System. The UK Department of Health and Social Care funded the REal-time Assessment of Community Transmission-2 (REACT-2) study to estimate community prevalence of SARS-CoV-2 IgG (immunoglobulin G) antibodies in England. Data Collection/Processing. We obtained random cross-sectional samples of adults from the National Health Service (NHS) patient list (near-universal coverage). We sent participants a lateral flow immunoassay (LFIA) self-test, and they reported the result online. Overall, 905 991 tests were performed (28.9% response) over 6 rounds of data collection (June 2020–May 2021). Data Analysis/Dissemination. We produced weighted estimates of LFIA test positivity (validated against neutralizing antibodies), adjusted for test performance, at local, regional, and national levels and by age, sex, and ethnic group and area-level deprivation score. In each round, fieldwork occurred over 2 weeks, with results reported to policymakers the following week. We disseminated results as preprints and peer-reviewed journal publications. Public Health Implications. REACT-2 estimated the scale and variation in antibody prevalence over time. Community self-testing and -reporting produced rapid insights into the changing course of the pandemic and the impact of vaccine rollout, with implications for future surveillance. (Am J Public Health. 2023;113(11):1201–1209. https://doi.org/10.2105/AJPH.2023.307381 )
One World Surgery
Authors: Overman Kelsey , Nicholson Peter , Nunziato Carl , Antunez Merlin , Daly Peter , Forseth Michael 
Published: September 2023

Abstract:
One World Surgery (OWS) is a medical mission organization that treats a variety of orthopaedic conditions and focuses on local partnerships, education, capacity-building, and high-quality care. OWS runs a Honduran ambulatory surgery center (ASC) with >50 full-time local staff; it operates year-round and accommodates visiting surgical teams bimonthly. Across its 12-year history, 8,703 surgical procedures have been performed and 54,940 total consults have been completed, with increasing autonomy of the local medical staff. From 2009 through 2021, OWS has provided 74 million U.S. dollars in surgical and consult patient care. By addressing global surgical disparities via life-enhancing surgical care in low- and middle-income country (LMIC) settings, the OWS ASC mission model may be a useful blueprint for other medical missions.
CFD-DEM Approach to Study the Proppant Transport and Placement under Different Perforation Conditions in Tortuous Hydraulic Fractures
Authors: Li Jun , Kuang Shibo , Huang Fayuan , Liu Pingli 
Published: September 2023

Summary
Hydraulic fracturing technology is widely used to extract unconventional and conventional gas/oil reservoirs. However, the distribution and packing pattern of the proppant remain as significant concerns in hydraulic fracturing, because they help enhance unconventional reservoir production by optimizing operational parameters. Previous studies focused on the proppant transport mechanism with critical factors, such as the perforation condition (perforation properties), in a straight fracture model, but the simplified fracture shape cannot generate enough actual results because the fracture is tortuous after shear displacement. As a result, there is a need to further study the effect of perforation conditions on proppant transport and distribution in tortuous fractures. The aim of this study is to present a combined numerical approach using computational fluid dynamics (CFD) and discrete element method (DEM) to simulate the fluid phase and proppant behavior, respectively. The CFD-DEM model was validated against the experimental results and found to be suitable for predicting proppant transport and distribution with different perforation conditions. The main conclusions are summarized as follows: (1) In various degrees of the tortuous fracture model, the final proppant packing shape was overall quadrilateral under the top- and middle-perforation injection modes. On the contrary, the proppant packing shape was triangular under bottom-perforation injection mode, resulting in a low dune height near the perforation. Furthermore, the final packing patterns changed from double-peaked stack to sole-peaked stack due to the injection mode changing to multiple-perforation injection mode. (2) In the tortuous fracture model, the bottom-perforation injection and multiple-perforation injection mode strategies should be applied first to improve the proppant transport efficiency.
Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson's disease: A DNA co-methylation network analysis
Authors: Lunnon Katie , Harvey Joshua , Smith Adam , Weymouth Luke , Smith Rebecca , Castanho Isabel , Hubbard Leon , Creese Byron , Bresner Kate , Williams Nigel , Pishva Ehsan 
Published: September 2023

Abstract
Parkinson’s disease is a highly heterogeneous disorder, encompassing a complex spectrum of clinical presentation including motor, sleep, cognitive and neuropsychiatric symptoms. We aimed to investigate genome-wide DNA methylation networks in post-mortem Parkinson’s disease brain samples and test for region-specific association with common neuropsychiatric and cognitive symptoms. Of traits tested, we identify a co-methylation module in the substantia nigra with significant correlation to depressive symptoms and with ontological enrichment for terms relevant to neuronal and synaptic processes. Notably, expression of the genes annotated to the methylation loci present within this module are found to be significantly enriched in neuronal subtypes within the substantia nigra. These findings highlight the potential involvement of neuronal-specific changes within the substantia nigra with regard to depressive symptoms in Parkinson’s disease.
Actuation performance of a microstructure with spin-current volume effect
Authors: Ono Takahito , Huang Yi-Te , Suzuki Kenta , Arisawa Hiroki , Kikkawa Takashi , Saitoh Eiji 
Published: September 2023

Abstract
In this work, the actuation of micromechanical structures based on spin-current volume effect (SVE) using an amorphous magnetic film of Tb20Fe24Co56 (TFC) with volume magnetostriction (VM) is demonstrated, and the actuation performances are evaluated. A 2 mm-diameter circular polyimide diaphragm coated with thin TFC/non-magnetic metal (NM) films is prepared as the micromechanical structure, and Pt, Cu, and W are used as the NM film. When an AC charge current flows through the TFC/NM film on the diaphragm under an external magnetic field in the diaphragm plane and orthogonal to the charge current, an AC spin-current flows in the NM film due to the spin-Hall effect. In the SVE, the spin-current transports angular momentum from the NM to TFC films, which modulates the magnetization fluctuation of the TFC film due to the spin-transfer torque, causing the volume modulation based on spin-lattice coupling. Thus, this SVE can induce the mechanical actuation of micromechanical structures. The force generated by the SVE actuation is evaluated from the mechanical resonance of the diaphragm, and it is found that the power density of the diaphragm actuator with the TFC/Pt films is larger than 1.17×106 W/m3 at 20 mA peak-to-peak AC current under 0.72 T magnetic field. This SVE is effective as a new actuation mechanism for microsystems.
Characteristics of Posterior Precortical Vitreous Pockets Visualized by Swept-Source OCT and en face OCT
Authors: Du Liping , An guangqi , Zhang Min , Lei Bo , Xin Xiaoyu , liu pei , Zhao Yu , Chen Haoxiang , Jin Xuemin 
Published: September 2023

Abstract
Purpose
To determine the characteristics of posterior precortical vitreous pockets (PPVPs) and to observe vitreous changes in myopic eyes by swept-source optical coherence tomography (SS-OCT) and en face imaging in a cohort of the Chinese Han population.
Methods
This was a cross-sectional study. Volunteers (235 participants, 374 eyes) received an SS-OCT examination. The heights and widths of the PPVPs were measured by SS-OCT. The area of the PPVPs was measured en face. The relationships between PPVP size and sex, age, axial length (AL) and spherical equivalent (SE) were evaluated.
Results
The mean width and height were 6711.64 ± 1241.87 µm and 662.47 ± 326.39 µm, respectively. The area of the PPVPs was 30.296 ± 9.114 mm2. Boat-shaped, oval, and hook-shaped PPVPs were observed in 73.26%, 21.12%, and 5.62% of all eyes, respectively; 73.53% of all PPVPs had channels communicating with Cloquet’s tubes. There was a significant difference in the PPVP width among the different age groups (F = 7.76, P = 0.002). Age had a positive correlation with the PPVP width (r = 0.526, P = 0.001). The PPVP height showed significant differences among the different age groups (F = 3.098, P = 0.027). However, there were no correlations between the AL and the PPVP width or height (P = 0.280; P = 0.328, P = 0.057, respectively).
Conclusions
Age and myopia affect the size of PPVPs. SS-OCT greatly facilitates visualization of the complex structure of the vitreous.
Brief Summary Statement:
Characteristics of PPVPs
Mild therapeutic hypothermia alleviated myocardial ischemia/reperfusion injury via targeting SLC25A10 to suppress mitochondrial apoptosis
Authors: Ma Senlin , Song Yun , Xu Yanxin , Wang Chao , Yang Yifan , Zheng Yanchao , Lu Qiuxin , Chen Qingjiang , Wu Jian , Wang Bin , Chen Mingquan 
Published: September 2023

Abstract
Purpose
Myocardial ischemia/reperfusion injury (MI/RI) is identified as a severe vascular emergency and the treatment strategy of MI/RI still needs further improvement. The present study aimed to investigate the potential effects of mild therapeutic hypothermia (MTH) on MI/RI and underlying mechanisms.
Methods
In in vivoexperiments, rats were subjected to ischemia/reperfusion (I/R) injury with MTH treatment. Cardiac function, myocardial injury, and mitochondrial apoptosis pathway were determined. Total proteins of rat myocardium were obtained for LC-MS/MS analysis. In in vitro experiments, AC16 cardiomyocytes were subjected to hypoxia and reoxygenation (H/R) with MTH treatment. The effects of MTH treatment on myocardial cell injury, mitochondrial dysfunction, mitochondrial apoptosis pathway induced by H/R were analyzed.
Results
In I/R rats, MTH treatment significantly improved the cardiac function and myocardial injury, and inhibited the activation of mitochondrial apoptosis pathway. Meanwhile, MTH treatment also attenuated myocardial infarction size and alleviated myocardial structural damage induced by I/R. The results of proteomics identified SLC25A10 as the main target of MTH treatment. Consistently, the expressions of SLC25A10 in I/R rat myocardium and H/R cardiomyocytes were significantly suppressed, which was effectively reversed by MTH treatment. In H/R cardiomyocytes, MTH treatment significantly improved cell injury, mitochondrial dysfunction, and inhibited the activation of mitochondrial apoptosis pathway. As expected, SLC25A10 deletion partially abolished the protective effects of MTH treatment on H/R cardiomyocytes.
Conclusions
These findings suggested that MTH treatment could protect against MI/RI by modulating SLC25A10 expression to suppress mitochondrial apoptosis pathway, providing new theoretical basis for clinical application of MTH treatment for MI/RI.
E2F7 as a Dual Regulator of Tumor Suppression and Chemoresistance in Glioblastoma multiforme
Authors: Meng Jiao , Qian Wei , Yang Zhenkun , Gong Lingli , Xu Daxing , Huang Hongbo , Jiang Xinyi , Pu Zhening , Yin Ying , Zou Jian 
Published: September 2023

Abstract
Background
Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer, and chemoresistance poses a significant challenge to the survival and prognosis of GBM. Although numerous regulatory mechanisms contributing to chemoresistance have been identified, many questions remain unanswered. This study aims to identify the mechanism of temozolomide (TMZ) resistant in GBM.
Methods
Since a temozolomide (TMZ) resistance model in vivo has been published in our group, the present study has employed transcriptome sequencing and experiments to analyze the function of E2F7 in GBM during the TMZ treatment, and the ChIPBase and PROMO database was used to explore the upregulators of E2F7 in TMZ resistance tumors, further in vivo and in vitro experiments are required to confirm the results.
Results
The study revealed that E2F7 was significantly upregulated in TMZ resistant tumors, high expression of E2F7 inhibited GBM tumorigenesis and growth, and promoted chemoresistance by reducing drug uptake and facilitating efflux. Furthermore, we observed increased phosphorylation and activation of the p53 protein in TMZ-resistant tumors, which directly contributed to the transcriptional upregulation of E2F7.
Conclusions
E2F7 serves as a poor prognostic indicator for GBM, and potentially plays a crucial role in promotion of TMZ resistance, and the activation of the p53 protein in these TMZ resistance, which directly contributed to the transcriptional upregulation of E2F7.
Zero-shot learning enables instant denoising and super-resolution
in optical fluorescence microscopy
Authors: Dai Qionghai , Qiao Chang , Zeng Yunmin , Meng Quan , Chen Xingye , Chen Haoyu , Jiang Tao , Wei Rongfei , Guo Jiabao , Fu Wenfeng , Lu Huaide , Li Di , Wang Yuwang , Qiao Hui , Wu Jiamin , Li Dong 
Published: September 2023

Abstract
Computational super-resolution (SR) methods, including conventional analytical algorithms and deep learning models, have substantially improved optical microscopy. Among them, supervised deep neural networks have demonstrated outstanding SR performance, however, demanding abundant high-quality training data, which are laborious and even impractical to acquire due to the high dynamics of living cells. Here, we develop zero-shot deconvolution networks (ZS-DeconvNet) that instantly enhance the resolution of microscope images by more than 1.5-fold over the diffraction limit with 10-fold lower fluorescence than ordinary SR imaging conditions in an unsupervised manner without the need for either ground truths or additional data acquisition. We demonstrate the versatile applicability of ZS-DeconvNet on multiple imaging modalities, including total internal reflection fluorescence microscopy, three-dimensional (3D) wide-field microscopy, confocal microscopy, lattice light-sheet microscopy, and multimodal structured illumination microscopy (SIM), which enables multi-color, long-term, super-resolution 2D/3D imaging of subcellular bioprocesses from mitotic single cells to multicellular embryos of mouse and C. elegans.
Potential Role of Vitamin D and Antimicrobial Peptide LL-37 in Severity of Dental Caries: an Exvivo Study
Authors: Nireeksha Nireeksha , Hegde Mithra N , N Suchetha Kumari 
Published: September 2023

Abstract
Vitamin D performs various functions as a hormone by promoting calcium absorption but the role of vitamin D is most important is in the role in innate immunity cell differentiation, cell maturation through its genomic effects via vitamin D receptor. The immune response also plays a major role in tooth surface and supporting structure destruction and playing a major factor in high caries formation. The inflammatory cytokines are released has proinflammatory cytokines and stimulate cells in disease process. Therefore, in the present study we have evaluated the association of salivary vitamin D, LL-37, interleukins 6 and 17A in various levels of severity of dental caries. The study showed that, the salivary vitamin D statistically decreased with increasing severity of caries which showed that vitamin D plays an important role in prevention of caries.. Antimicrobial peptide LL-37 was higher in caries free group but was not statistically significant, salivary IL-6 level was higher in caries active group but intergroup comparison did not show significant difference, this could be attributed to the pro inflammatory activity of Interleukin 6. Salivary IL-17A did not show statistically significant between caries active and caries free group, this could be attributed to the levels of salivary LL-37 in saliva.