bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of salvage surgery with or without reirradiation for skull base meningiomas recurring after prior radiotherapy
Authors: Rubino Franco , Schur Solon , McGovern Susan L. , Kamiya-Matsuoka Carlos , DeMonte Franco , Raza Shaan M. 
Published: February 2023

OBJECTIVE
Long-term follow-up of meningiomas has demonstrated recurrence rates ranging from 2.5% to 48% after 10 years, depending on histology grade. There are limited data available to guide the management of recurrent and previously irradiated skull base meningiomas, and challenges related to salvage surgery, reirradiation, and lack of clear systemic therapy strategies remain. In this study, the authors analyzed data from their experience with recurrent and previously irradiated meningiomas to assess the impact of salvage surgery and reirradiation on progression-free survival (PFS).

METHODS
A retrospective cohort study of 48 patients with recurrent and previously irradiated meningiomas who were treated between 1995 and 2021 was conducted. Data were extracted from medical records and included clinical, radiological, and pathologic reports. Patients were clustered according to WHO grades. The authors analyzed the complications related to reirradiation and salvage surgery and the impact of different treatment modalities on PFS using Cox proportional hazard ratios.

RESULTS
Forty-eight patients (33 with WHO grade I, 11 with WHO grade II, and 4 with WHO grade III meningiomas) were treated for 143 recurrences after their first radiation treatment. For WHO grade I meningiomas, there was no change in tumor control rates with adjuvant repeat radiotherapy (HR 0.784, 95% CI 0.349–1.759; p = 0.55), and in terms of extent of resection (EOR), subtotal resection (STR) alone was associated with an increased risk of recurrence when compared with gross-total resection (GTR) (HR 3.38, 95% CI 1.268–9.036; p = 0.0189). For WHO grade II meningiomas, GTR did not significantly confer improved tumor control relative to STR (HR 0.42, 95% CI 0.17–1.037; p = 0.055), but adjuvant repeat radiotherapy after STR was associated with improved outcomes (HR 0.316, 95% CI 0.13–0.768; p = 0.0029). Finally, for WHO grade III meningiomas, EOR did not correlate with outcomes (HR 0.75, 95% CI 0.22–2.482; p = 0.588), but repeat radiotherapy alone was associated with a decreased odds of progression (HR 0.276, 95% CI 0.078–0.97; p = 0.0028).

CONCLUSIONS
This study examined the impact of retreatment on PFS in a large cohort of patients with recurrent meningiomas that had been previously irradiated. At the time of recurrence, WHO grade I meningiomas exhibited improved PFS with GTR, subtotally resected WHO grade II meningiomas appeared to have improved PFS when reirradiated, and reirradiation in WHO grade III meningiomas showed improved PFS.
Endovascular treatment versus standard medical treatment for basilar artery occlusion: a meta-analysis of randomized controlled trials
Authors: Yu Ying , Lou Yake , Cui Rongrong , Miao Zhongrong , Lou Xin , Ma Ning 
Published: February 2023

OBJECTIVE
Acute ischemic stroke caused by basilar artery occlusion (BAO) is devastating, but the optimal treatment for patients with BAO remains controversial. In this study, the authors aimed to investigate the safety and efficacy of endovascular treatment (ET) versus standard medical treatment (SMT) in patients with BAO.

METHODS
The PubMed, Embase, and Cochrane Library databases were searched for randomized controlled trials (RCTs). The primary outcome was good functional outcome, defined as a modified Rankin Scale (mRS) score of 0–3 at 90 days. The secondary efficacy outcome was excellent functional outcome defined as an mRS score of 0–2 at 90 days. The safety outcomes included mortality at 90 days and symptomatic intracranial hemorrhage (sICH). Subgroup analyses were carried out based on race (Asian or non-Asian).

RESULTS
Four RCTs of 988 patients (556 in the ET group and 432 in the SMT group) were included in this meta-analysis. The proportion of good functional outcome in the ET group was significantly higher than that in the SMT group (45.1% vs 29.6%; number needed to treat 6.45; RR 1.54, 95% CI 1.16–2.06; p = 0.003, I2 = 60%). The subgroup analysis based on race showed a significant difference between Asian and non-Asian race in the primary outcome (p = 0.03, I2 = 78.5%). Patients in the ET group had a higher rate of excellent functional outcome at 90 days than those in the SMT group (34.9% vs 20.6%; RR 1.83, 95% CI 1.07–3.12; p = 0.03, I2 = 80%). Patients in the ET group had a lower mortality at 90 days (35.6% vs 45.4%; RR 0.77, 95% CI 0.66–0.89; p = 0.0007, I2 = 0%) but a higher rate of sICH (5.4% vs 0.5%; RR 8.29, 95% CI 2.49–27.66; p = 0.0006, I2 = 0%) than those in the SMT group.

CONCLUSIONS
ET may improve the functional outcome and reduce mortality at 90 days but increase the risk of sICH compared with SMT in patients with BAO. This conclusion needs to be confirmed in non-Asian populations in future studies.
Systematic review registration no.: CRD42022357718 (https://www.crd.york.ac.uk/prospero/)
Clinical outcomes of the traditional dual growing rod technique combined with apical pedicle screws in the treatment of early-onset scoliosis: preliminary results from a single center
Authors: Yang Yang , Su Zhe , Wang Shengru , Du You , Zhao Yiwei , Lin Guanfeng , Ye Xiaohan , Wu Nan , Zhuang Qianyu , Zhang Terry Jianguo 
Published: February 2023

OBJECTIVE
Limited control of an apical deformity is a major disadvantage in the traditional dual growing rod (TDGR) technique. Previous literature has reported the results of apical pedicle screw placement (APS) as an apical control technique in patients with early-onset scoliosis (EOS). However, the clinical outcomes, indications, and complications of the TDGR technique combined with APSs have not been well described. The purpose of this study was to evaluate the preliminary clinical outcomes of the TDGR technique combined with APSs in EOS patients.

METHODS
Clinical data of 12 patients with EOS who were treated with the TDGR technique combined with APSs at the index surgery at the authors’ center from January 2010 to January 2020, with a minimum 2-year follow-up, were retrospectively reviewed. Indications for the use of APSs included 1) no vertebral segmentation failure, fused ribs, or multiple hemivertebrae at the apex; 2) at least 2 normal discs around the apex; and 3) proper development of apical pedicles on the convex side. Etiology, age at index surgery, number of lengthening procedures, follow-up duration, and complications were recorded. Radiographic measurements included Cobb angle, apical vertebral translation (AVT), apical vertebral rotation (AVR), thoracic kyphosis, lumbar lordosis, spine height, and space available for the lung (SAL).

RESULTS
The mean follow-up period was 4.0 ± 1.4 years, with a mean of 4.8 lengthening procedures per patient. The mean Cobb angle improved from 61.7° ± 10.4° to 19.9° ± 9.0° after the index surgery (19.6° ± 9.4° at the latest follow-up). The mean postindex AVT decreased to 16.8 ± 8.9 mm from a preindex AVT of 56.3 ± 9.7 mm and further improved to 13.6 ± 10.0 mm at the latest follow-up. The mean annual increases in T1–12 and T1–S1 height were 9.0 ± 4.7 mm and 13.9 ± 6.5 mm, respectively. The SAL improved from 0.91 to 1.04 at the latest follow-up. AVR improved significantly after the index surgery (p = 0.013), while minor deterioration was observed after repeat lengthening procedures. Five complications (2 implant related and 3 alignment related) occurred in 4 patients.

CONCLUSIONS
For EOS patients with good flexibility (without segmentation failure or multiple hemivertebrae at the apex), the TDGR technique combined with APSs can improve primary curve correction, maintain good correction results, and allow continuous spine growth, which may reduce the risks of complications during lengthening treatment. More multicenter prospective studies with larger samples are needed to further validate the findings of this study.
Mean Atd Angle among Type 2 Diabetes Mellitus Patients Visiting a Tertiary Care Centre: A Descriptive Cross-sectional Study
Authors: Shrestha Sheprala , Mansur Dil Islam , Tamrakar Rajendra , Shrestha Pragya , Maskey Sunima 
Published: February 2023

Introduction: An atd angle is one of the dermatoglyphic patterns which is an indication of the degree of distal displacement of the axial triradius on the palm. This is one of the markers of diabetes mellitus that is used as a screening tool in order to reduce the risk of onset and initiate early treatment. The aim of this study is to find the mean atd angle among type 2 diabetes mellitus patients visiting a tertiary care centre.
Methods: This descriptive cross-sectional study was done among diabetic patients in a tertiary centre from 9 June 2021 to 5 May 2022. Ethical approval was taken from Institutional Review Committee (Reference number: KUSMS/IRC 40/2021). Both palm prints of study subjects were taken and the atd angle was measured. Convenience sampling was done. Point estimate and 95% confidence interval were calculated.
Results: Among 133 palm prints of diabetic patients, the mean atd angle was 42.13±4.73° (male: 41.90±4.75° and female: 42.35±4.70°). The right palms showed mean atd angle of 42.31±4.42° and that of left palms was 41.94±5.04°.
Conclusions: The mean atd angle among type 2 diabetes mellitus patients is similar to other studies done in similar settings.
Mindfulness and Care Experience in Family Caregivers of Persons Living with Dementia
Authors: Tolea Magdalena I. , Camacho Simone , Cohen Iris R. , Galvin James E. 
Published: February 2023

Background: Greater mindfulness, the practice of awareness and living in the moment without judgement, has been linked to positive caregiving outcomes in dementia caregivers and its impact attributed to greater decentering and emotion regulation abilities. Whether the impact of these mindfulness-based processes varies across caregiver subgroups is unclear. Objective: Analyze cross-sectional associations between mindfulness and caregiver psychosocial outcomes, considering different caregiver and patient characteristics. Methods: A total of 128 family caregivers of persons living with Alzheimer’s disease and related disorders were assessed on several mindfulness measures (i.e., global; decentering, positive emotion regulation, negative emotion regulation) and provided self-reported appraisals of caregiving experience; care preparedness; confidence, burden, and depression/anxiety. Bivariate relationships between mindfulness and caregiver outcomes were assessed with Pearson’s correlations and stratified by caregiver (women versus men; spouse versus adult child) and patient (mild cognitive impairment (MCI) versus Dementia; AD versus dementia with Lewy bodies; low versus high symptom severity) characteristics. Results: Greater mindfulness was associated with positive outcomes and inversely associated with negative outcomes. Stratification identified specific patterns of associations across caregiver groups. Significant correlations were found between all mindfulness measures and caregiving outcomes in male and MCI caregivers while the individual mindfulness component of positive emotion regulation was significantly correlated to outcomes in most caregiver groups. Conclusion: Our findings support a link between caregiver mindfulness and improved caregiving outcomes and suggest directions of inquiry into whether the effectiveness of dementia caregiver-support interventions may be improved by targeting specific mindfulness processes or offering a more inclusive all-scope approach depending on individual caregiver or patient characteristics.
Psychosocial health and activities during the COVID-19 pandemic
Authors: Göktaş Ayşe , Varlı Murat 
Published: February 2023

BACKGROUND: The COVID-19 pandemic has become a major cause of stress at work. OBJECTIVE: To examine the effect of self-management and self-control skills on perceived stress of employees in the COVID-19 period. METHODS: The study’s self-administered survey included demographics and the Perceived Stress Scale (PSS) and Self-Control and Self-Management Scale (SCMS). Associations with PSS were determined using a multiple variable linear regression analysis. RESULTS: Scores for stress (28.45±7.82) and self-management (55.73±12.15) were moderate for employees. Of the 181 employees, 41.43% had a mild, 52.48% had moderate, and 6.07% had severe stress levels. Stress was significantly associated with lower self-management level. A negative relation was found between SCMS and PSS (p = 0.000, r = –0.320). Employees with high self-management skills had low stress levels. Employees also reported negative changes to physical activity, income and sleep. Gender, occupation, income category, compliance with COVID-related rules and self-management were associated with levels of stress (p < 0.05). The regression model explained 24.8% of the variance in stress perception (R2 = 0.248, F = 11.452, p = 0.000). Multiple linear regression analysis showed gender (β = 5.089, 95% CI: 2.820 to 7.358, p = 0.000) compliance with COVID-related rules (β = 2.274, CI: 0.066 to 4.483, p = 0.044), a decrease in income (β = 2.051, CI: –0.64 to 4.166, p = 0.057) and self-management (β = -0.173, CI: –0.258 to –0.087, p = 0.000) were significantly associated with lower scores in the stress perception. CONCLUSION: Self-control and self-management were associated with a decline in mental health. Health-promotion strategies directed at adopting or maintaining positive self-control and self-management-related behaviors should be utilized to address increases in psychological distress during the COVID-19 pandemic.
EVALUATION OF THE POTENTIAL OF ONION PEEL COMPOSITE AS AN ADSORBENT FOR THE REMOVAL OF CATIONS IN FISH POND WASTEWATER
Authors: Aliyu A. O. , Musa Faiza Kallamu  , Faruruwa M. D. , Okunola O. J. 
Published: February 2023

Toxic metals in wastewater when discharge in to the environment can accumulate in vital organs when ingested, and get concentrated through the food chain causing poisonous effects to living organisms. Alumina modified onion peel composite was used in this study as an adsorbent for the removal of lead, nickel, chromium, copper and zinc ions from Fish pond wastewater via adsorption process. Batch adsorption experiments were conducted to examine the effect of adsorbent dosage, pH, adsorbate concentration, and contact time on the adsorption of the cations. The optimum adsorbent dosage was 0.3g, pH was 2, contact time was 60 mins and initial concentration was found to be 10 mg/l. The concentration of metal ions present were analyzed using Atomic Absorption Spectrophotometer. The characterization by Fourier Transform Infrared (FTIR) showed absorbance peaks that correspond to hydroxyl, aldehyde, alkyl, amide and carboxylic acid functional groups. These functional groups helped in enhancing the adsorption of the metal ions. Scanning Electron microscope (SEM) analysis was carried out for the morphological characteristics of the adsorbent, before and after adsorption. The experimental isotherm data were analyzed using linear form of Langmuir and Freundlich isotherm models. The Langmuir isotherm provided the best fit for the sorption of Zn2+, Cu2+, Cr3+ and Pb2+ ions with the correlation coefficient (R2) as 0.981, 0.994, 0.9192 and 0.9478 respectively while the Freundlich isotherm had a best fit for the sorption of Ni2+ with the correlation coefficient (R2) of 0.9574. The maximum monolayer adsorption (qm) for copper was found to be the highest
PENGARUH KOMBINASI EKSTRAK BAWANG MERAH DAN AIR KELAPA PADA TAHAP MULTIPLIKASI PLANLET KENTANG (Solanum tuberosum [L.] cv. Granola) MENGGUNAKAN MEDIA MURASHIGE DAN SKOOG (MS)
Authors: Asyahidah Rr Khoirunnisa , Nugrahani Pangesti , Makhziah Makhziah 
Published: February 2023

Peningkatan produktivias tanaman kentang dapat dilakukan dengan penyediaan bibit unggul yang bersertifikat seperti menggunakan metode perbanyakan secara kultur jaringan. Tujuan dari penelitian ini ialah menganalisis Pengaruh Kombinasi Ekstrak Bawang Merah Dan Air Kelapa Terhadap Pertumbuhan In-Vitro Planlet Kentang (Solanum Tuberosum [L.] cv. Granola) Pada Media Murashige Dan Skoog (MS). Rancangan percobaan yang digunakan Rancangan Acak Lengkap (RAL) Faktorial Penelitian menggunakan 2 faktor perlakuan yaitu pemberian ekstrak bawang merah menggunakan 4 taraf B0(kontrol), B1(20 g L-1), B2(30 g L-1), B3(40 G L-1) dan air kelapa menggunakan 4 taraf K0(kontrol), K1(50 ml L-1), K2(75 ml L-1) dan K3(100 ml L-1). Hasil penelitian menunjukkan terdapat interaksi dengan kombinasi terbaik 20 g ekstrak bawang merah dan 50 ml air kelapa memberi pengaruh nyata pada perameter pertumbuhan panjang planlet dengan planlet kentang secara in vitro.
KOMPOSISI VEGETASI DI RUANG TERBUKA HIJAU DATARAN RENDAH, SURABAYA TIMUR
Authors: Tarigan Puji Lestari , Dewanti Felicitas Deru 
Published: February 2023

Keragaman jenis tumbuhan dapat ditemukan pada kondisi lahan yang berbeda. Di Ruang Terbuka Hijau terdapat berbagai jenis tanaman yang tumbuh bebas. Kualitas ruang terbuka sangat berkaitan dengan vegetasi yang tumbuh di ruang tersebut, yang menyangkut jenis, bentuk, lokasi tanam, jumlah dan kondisinya. Struktur dan komposisi vegetasi tumbuhan dipengaruhi oleh interaksi komponen ekosistem lainnya sehingga vegetasi yang tumbuh secara alami merupakan hasil interaksi dari berbagai faktor lingkungan. Vegetasi dataran rendah sangat bervariasi. Untuk mengetahui keanekaragaman vegetasi pada Ruang Terbuka Hijau di dataran rendah dapat menggunakan analisis vegetasi. Analisis vegetasi merupakan suatu cara untuk mempelajari susunan dan atau komposisi vegetasi pada sekelompok tumbuhan. Alat dan bahan yang digunakan pada penelitian yaitu, meteran, tali rapia, cangkul kecil, alat tulis dan kamera. Metode yang digunakan pada penelitian ini adalah metode kuadrat. Metode kuadrat merupakan cara yang mudah dan cepat untuk mengetahui komposisi, dominansi, dan menaksir komposisi vegetasi. Ukuran kuadrat yang digunakan yaitu, 1x1 m. Pengamatan dilakukan sebanyak 8 ulangan. Penentuan analisis dilakukan dengan melempar kuadrat ke areal secara acak. Parameter pengamatan terdiri dari; Kerapatan (K), Kerapatan Relatif (KR), Frekuensi (F), Frekuensi Relatif (FR) dan Indeks Nilai Penting (INP). Hasil pengamatan menunjukkan bahwa Cyperus rotundus memiliki nilai K=60, KR=29,8%, FM=37,5%, FR=11,1%, dan INP=40,9%. Tumbuhan ini mendominasi Ruang Terbuka Hijau pada dataran rendah, Surabaya Timur. Karena tumbuhan tersebut memiliki daya adaptasi yang besar dalam pertumbuhan dan perkembangannya. Keberadannya mendukung fungsi ekologis Ruang Terbuka Hijau.
PENGARUH KONSENTRASI ZAT PENGATUR TUMBUH ATONIK PADA DUA VARIETAS TANAMAN JAHE (Zingiber officinale) PADA PERTUMBUHAN FASE VEGETATIF
Authors: Risano Ardito , Sutini Sutini , Pribadi Didik Utomo 
Published: February 2023

Tanaman jahe (Zingiber officinale) merupakan salah satu komoditas tanaman yang termasuk dalam suku Zingiberaceae yang dikenal dengan ginger. Tanaman jahe merupakan rempah yang paling populer dan dimanfaatkan bangsa Eropa pada jaman dahulu. Selain sebagai tanaman herbal, tanaman jahe menyimpan zat antioksidan yang berguna bagi kesehatan tubuh manusia. Pada tahun 2016, produksi tanaman jahe cenderung mengalami penurunan sedangkan permintaan terus meningkat. Oleh karena itu, perkembangbiakan tanaman jahe dapat dilakukan dengan menggunakan zat pengatur tumbuh auksin yang dapat memacu pertumbuhan dan perkembangan tanaman jahe. Tujuan penelitian ini adalah untuk mengetahui formulasi yang optimal terhadap pertumbuhan tanaman jahe pada fase vegetatif. Penelitian dilakukan pada bulan februari hingga bulan April di Lahan Pertanian, Fakultas Pertanian, Universitas Pembangunan Nasional “Veteran” Jawa Timur. Penelitian ini menggunakan percobaan yang disusun menggunakan Rancangan Acak Lengkap (RAL) dan diulang sebanyak 3 kali. Faktor I Konsentrasi ZPT Atonik sebesar 0 ml/l (kontrol), Konsentrasi ZPT Atonik sebesar 2 ml/l, Konsentrasi ZPT Atonik sebesar 4 ml/l, Konsentrasi ZPT Atonik sebesar 6 ml/l, Konsentrasi ZPT Atonik sebesar 8 ml/l, dan Konsentrasi ZPT Atonik sebesar 10 ml/l. Faktor II Varietas Jahe Emprit, dan Varietas Jahe Merah. Hasil penelitian menunjukkan perbedaan dosis konsentrasi Zat Pengatur Tumbuh (ZPT) Atonik terhadap berat kering pada fase vegetatif memiliki nilai BNT 5% sejumlah 7,95. Hal ini disebabkan karena pemberian auksin yang tepat dapat meningkatkan penyerapan unsur hara melalui akar. Pada hasil penelitian juga didapatkan perbedaan yang nyata pada perbedaan varietas tanaman jahe yang berbeda nyata terhadap panjang akar dengan nilai BNT 5% sejumlah 12,46. Hal ini disebabkan karena hormon tersebut dapat memacu serta memacu uatu aktivitas biokimia. Pada diameter batang memiliki perbedaan yang nyata pada perbedaan varietas tanaman jahe yang berbeda nyata dengan nilai BNT 5% sejumlah 0,36. Hal ini disebabkan karena bahan yang digunakan untuk menyuplai pembentukan rimpang tersedia dalam jumlah banyak, maka rimpang yang terbentuk lebih besar dan memengaruhi diameter rimpang.
A hybrid individual-based mathematical model to study bladder infections
Authors: Lasri Doukkali Anas , Lorenzi Tommaso , Parcell Benjamin J. , Rohn Jennifer L. , Bowness Ruth 
Published: February 2023

IntroductionBladder infections are common, affecting millions each year, and are often recurrent problems.MethodsWe have developed a spatial mathematical framework consisting of a hybrid individual-based model to simulate these infections in order to understand more about the bacterial mechanisms and immune dynamics. We integrate a varying bacterial replication rate and model bacterial shedding as an immune mechanism.ResultsWe investigate the effect that varying the initial bacterial load has on infection outcome, where we find that higher bacterial burden leads to poorer outcomes, but also find that only a single bacterium is needed to establish infection in some cases. We also simulate an immunocompromised environment, confirming the intuitive result that bacterial spread typically progresses at a higher rate.ConclusionsWith future model developments, this framework is capable of providing new clinical insight into bladder infections.