bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hobbesian Natural Philosophy as Mixed Mathematics
Authors: Adams Marcus P 
Published: January 2025

Abstract
Chapter 5 offers an alternative account of the relationship of Hobbesian geometry to natural philosophy by arguing that mixed mathematics provides Hobbes with a model for thinking about it. In mixed-mathematics disciplines, such as optics, harmonics, and mechanics, one may borrow causal principles from one science and use them in another science without a deductive relationship. In Hobbes’s descriptions and practice of natural philosophy, one may appeal to everyday experience or experiments for the demonstration that something happens (the “that”) and borrow the cause (the “why”) from geometry. The chapter considers Hobbes’s comments concerning and relation to Aristotelian subalternate sciences and to Isaac Barrow’s broadening of mixed mathematics, contrasting these affinities to Hobbes’s contemporary John Wallis’s understanding. According to Hobbes, maker’s knowledge from geometry provides the “why” in mixed-mathematical explanations, and any explanation must be constrained by a priori principles of motion. The chapter examines three explanations in Hobbes’s natural philosophy and displays his behavior of borrowing and citing geometrical principles and then mixing those principles with appeals to experience. The chapter also contrasts the benefits of the mixed mathematics view with weaknesses of Shapin and Schaffer’s (1985) account of Hobbes’s dispute with Robert Boyle.
Experience in Hobbesian Civil Philosophy and Civil History
Authors: Adams Marcus P 
Published: January 2025

Abstract
Although Hobbes’s interests in the historical past are various and span his corpus, chapter 6 examines why Hobbes thought it was legitimate to borrow causal principles from civil philosophy within certain parts of historical explanations (called Hobbesian “historiography” in the chapter). This focus on historiography is motivated by a tension in Hobbes’s own view: although he places natural history and political history outside of the “subject” of philosophy because they are merely knowledge from sense, he admits that they are “useful” and even “necessary” for philosophy. Rather than understanding this as asserting a need for preparation in history by philosophers, chapter 6 shows that in an explanation of the historical past, both political history and civil philosophy (one of Hobbes’s two sciences) play essential roles: while political history demonstrates ‘that’ some event has occurred, civil philosophy provides the reason ‘why’ with a borrowed causal principle. Seeing this connection between civil philosophy and historiography illuminates the source of tension in Hobbes’s seemingly paradoxical statements about the place of history and shows that the explanations in chapter 45 of Leviathan Part IV are structurally analogous to those in the natural philosophy of De corpore Part IV, and so likewise are the explanations in the historiographical dialogue Behemoth and the natural-philosophical Dialogus Physicus.
High levels of heat stress among sugarcane workers in Thailand
Authors: Tantipanjaporn Tadpong , Povey Andrew , Shiels Holly A , van Tongeren Martie 
Published: January 2025

Abstract

Objectives
With continued global warming, the effects of elevated temperatures on the health of agricultural workers are a particular concern. This study characterized the levels of heat stress in Thai sugarcane workers and investigated whether season and harvesting method were associated with it.

Methods
Three hundred sugarcane workers in Nakhon Sawan Province, Thailand, were recruited, and information on demographics, working conditions, and clothing characteristics was collected from participants during the cooler months (n = 152 participants, mid-January to mid-February) and hotter month (n = 148, March). Heat stress was measured using the Wet Bulb Globe Temperature (WBGT) index, and the WBGT instruments were operated for a full work shift in the sugarcane fields where the participants worked. One-hour time weighted average (TWA) effective WBGT (WBGTeff-1hrTWA) estimates were determined for different times of the day based on the measured WBGT and clothing adjustment factor.

Results
The average WBGTeff-1hrTWA in the cooler months ranged from 22.5 °C during the early morning to 31.3 °C during the hottest time of the day, and for the hotter month, it ranged from 25.4 °C to 33.9 °C, respectively. The measured WBGT, natural wet-bulb temperature (Tnwb), dry-bulb temperature (Tdb), globe temperature (Tg), air velocity (Av), and absolute water vapor pressure (ea) were all statistically significantly higher in the hotter month than in the cooler months. Harvesting during the hotter month and harvesting burnt sugarcane were significantly associated with increased effective WBGT. The harvesters’ heat stress in both seasons exceeded the American Conference of Governmental Industrial Hygienists - Threshold limit value for 72.7% of the working time in the cooler months and 90.9% in the hotter month.

Conclusions
The heat stress in Thai sugarcane workers was high in both seasons, particularly in the hotter month and when harvesting burnt sugarcane. This results in a very high risk of developing heat-related health effects, and measures are needed to reduce heat stress. Heat stress in agricultural and other outdoor work in tropical climates is an immediate and growing problem.
Unveiling cross-reactivity: implications for immune response modulation in cancer
Authors: Pretti Marco Antônio M , Vieira Gustavo Fioravanti , Boroni Mariana , Bonamino Martín H 
Published: January 2025

Abstract
Antigen recognition by CD8+ T-cell receptors (TCR) is crucial for immune responses to pathogens and tumors. TCRs are cross-reactive, a single TCR can recognize multiple peptide-Human Leukocyte Antigen (HLA) complexes. The study of cross-reactivity can support the development of therapies focusing on immune modulation, such as the expansion of pre-existing T-cell clones to fight pathogens and tumors. The peptide-HLA (pHLA) surface has previously been used to identify TCR cross-reactivities. In the present work, we sought to perform a comprehensive analysis of peptide-HLA by selecting thousands of human and viral epitopes. We profit from established docking models to identify features from different spatial perspectives of HLA-A*02:01, explore similarities between self and non-self epitopes, and list potential cross-reactive epitopes of therapeutic interest. A total of 2631 unique epitopes from representative viral proteins or human proteins were modeled. We were able to demonstrate that cross-reactive CDR3 sequences from public databases recognize epitopes with similar electrostatic potential, charge, and spatial location. Using data from published studies that measured T-cell reactivity to mutated epitopes, we observed a negative correlation between epitope dissimilarity and T-cell activation. Most analysed cancer epitopes were more similar to self epitopes, yet we identified features distinguishing those more similar to viral antigens. Finally, we enumerated potential cross-reactivities between tumoral and viral epitopes and highlighted some challenges in their identification for therapeutic use. Moreover, the thousands of peptide-HLA complexes generated in our work constitute a valuable resource to study T-cell cross-reactivity.
Multidimensional structural analyses revealed a correlation between thalamic atrophy and white matter degeneration in idiopathic dystonia
Authors: Xu Jinping , Cheng Qinxiu , Zhang Yue , Luo Yuhan , Zhong Linchang , Liu Huiming , Zhang Haoran , Yang Zhengkun , Zhang Jiana , Ou Zilin , Yan Zhicong , Peng Kangqiang , Liu Gang 
Published: January 2025

Abstract
Although aberrant changes in grey and white matter are core features of idiopathic dystonia, few studies have explored the correlation between grey and white matter changes in this disease. This study aimed to investigate the coupling correlation between morphological and microstructural alterations in patients with idiopathic dystonia. Structural T1 imaging and diffusion tensor imaging were performed on a relatively large cohort of patients. Multidimensional structural analyses, including voxel-based analyses, voxel-based morphology, fixel-based analyses and surface-based morphometry, were performed to explore these structural alterations. Probabilistic tractography and correlation analyses were employed to examine these relationships. A total of 147 patients with idiopathic dystonia and 137 healthy controls were recruited in this study. There were no significant differences in the cortical morphometry between patients with idiopathic dystonia and healthy controls using voxel- and surface-based morphometry. However, the grey matter volume of the bilateral thalamus, fractional anisotropy in the right anterior corona radiata, right retrolenticular part of the internal capsule and right posterior corona radiata, and the fibre density and cross-section combined in the fibre tract connecting the left ventral posterolateral thalamic nucleus and left area 5 m, were significantly decreased in patients with idiopathic dystonia compared with those in healthy controls. Furthermore, the reduced grey matter volume in the right thalamus not only correlated with the disease duration but also with the reduced fractional anisotropy in the right posterior corona radiata and decreased the fibre density and cross-section combined in the fibre tract connecting the left ventral posterolateral thalamic nucleus and the left area 5 m in patients with idiopathic dystonia. These findings suggest that the thalamus is structurally impaired in idiopathic dystonia and that microstructural disruption in thalamocortical projections occurs secondary to thalamic atrophy.
Left coronary ostial isolation in a young boy caused by a dysplastic aortic valve: a case report
Authors: Fitzgerald Nicholas , Liava’a Matthew , Gnanappa Ganesh , Ayer Julian 
Published: January 2025

Abstract

Background
Ischaemic cardiac chest pain and coronary artery abnormalities are uncommon in children. The long-term implications of missed or delayed diagnosis are myocardial ischaemia and risk of sudden cardiac death. Improvement in non-invasive imaging has made diagnosis and surgical planning possible with multi-modal imaging.

Case summary
A 12-year-old boy with ischaemic chest pain caused by isolation of the left coronary ostium in the context of a dysplastic aortic valve. There was a delay to formal diagnosis. Surgical aortic valve repair resulted in complete resolution of symptoms. Ethics approved (SCHN: CCR2023/5).

Discussion
Isolation of the left coronary ostium caused by a dysplastic aortic valve (without supravalvar stenosis) is an example of a rare cause of ischaemic chest pain in children. To our knowledge, only 10 paediatric case reports are published in English. In reported cases, presenting features varied from poor feeding and a murmur in infants to chest pain, syncope, or cardiac arrest in adolescents. Historically, angiography during a cardiac catheter procedure was required for diagnosis; however, improvements in non-invasive imaging techniques have resulted in the diagnosis being possible on echocardiography (supported by computed tomography angiography or cardiac magnetic resonance imaging).
Small-scale genetic differentiation in mean flowering time, but not in plasticity, along a geothermal heating gradient
Authors: Valdés Alicia , Helmutsdóttir Vigdís F , Marteinsdóttir Bryndís , Ehrlén Johan 
Published: January 2025

Abstract
Genetic differentiation in traits is assumed to frequently occur in response to divergent natural selection. For example, developmental traits might respond to differences in climate. However, little is known about when and at which spatial scales environmental differences lead to genetic differentiation, and to what extent there is genetic differentiation also in trait plasticity. Using a crossing design and a greenhouse heating experiment, we investigated genetic differentiation in thermal sensitivity of flowering time in a perennial herb along small-scale gradients in geothermal soil heating in Iceland. We found additive genetic variation in both flowering time and thermal plasticity of flowering time. Genetic differentiation in the median flowering date of individuals showed a counter-gradient pattern; flowering being earlier at higher greenhouse temperatures, while at a given temperature individuals originating from warmer soils flowered later than individuals from colder soils. We found no corresponding pattern for plasticity, suggesting that genetic differentiation in phenology in response to soil heating has occurred through changes in trait means rather than in plasticity. Findings such as these identifying genetic trait differentiation along an environmental gradient are key to understand how environmental variation can drive the process of local adaptation, and to predict responses to future environmental changes.
Hyperbolicity and Model-Complete Fields
Authors: Szachniewicz Michał , Ye Jinhe 
Published: January 2025

Abstract
We study model-complete fields that avoid a given quasi-project variety $V$. There is a close connection between hyperbolicity of $V$ and the existence of the model companion for the theory of characteristic-zero fields avoiding rational points on $V$. This gives a model theoretic notion of hyperbolicity that we call excludability. In particular, we show that if $V$ is a Brody hyperbolic projective variety over ${\mathbb{Q}}$ with $V({\mathbb{Q}}) = \varnothing $, then the model companion, called $V\textrm{XF}$, exists. We also study some model-theoretic properties of $V\textrm{XF}$. This extends the results for curves by Will Johnson and the second author.
External quality assurance (EQA) network in South and South-East Asia: experience and results from an international EQA programme in One Health sector reference laboratories
Authors: Kostyanev Tomislav , Al-Mir Hiba , Prifti Kristi , Rasmussen Lone Brink , Abegaz Freshwork Ayalew , Teixeira Dos Santos Patrícia , Kwon Soo-Young , Prathan Rangsiya , Luang Tongkum Taradon , Chanchaithong Pattrarat , Santanirand Pitak , Kamjumphol Watcharaporn , Mogeni Ondari D , Guarnacci Tobin , Poudyal Nimesh , Holm Marianne , Paveenkittiporn Wantana , Chuanchuen Rungtip , Hendriksen Rene S 
Published: January 2025

Abstract

Objectives
External quality assurance (EQA) is an objective tool to assess laboratories’ diagnostic performance and their adherence to recognized international standards. External Quality Assessment in Asia (EQASIA) is an EQA network in South and South-East Asia established in 2020 with the aim of improving the quality of bacteriology diagnostics across all One Health sectors in the region. The aim of this paper is to provide a comprehensive overview of the EQA results collected from the EQASIA network and to assess improvements among the participating laboratories.

Methods
Six EQA rounds were conducted between 2021 and 2023, each composed of different panels of WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS) and The Food and Agriculture Organization of the United Nations (FAO) priority pathogens of interest to both the human and animal health sector.

Results
Between 24 and 32 laboratories signed up for six EQA rounds (EQA1–6). Participating laboratories were able to isolate and correctly identify most of the isolates across the EQA panels except for the Campylobacter spp. and Enterococcus spp. panels. The overall performance of laboratories across the six EQAs was between 75% and 100% (average 93.3% and median 93.6%). The obtained results showed a significant improvement in laboratories’ performance over time.

Conclusions
Laboratory capacity development and quality assurance in a microbiology laboratory are of particular importance especially in the context of antimicrobial resistance (AMR) and One Health surveillance. The EQASIA programme has the potential to validate laboratories’ performance in detecting important One Health pathogens, generating reliable data for effective surveillance to curb AMR.
Impact of climate change on the distribution of the citrus longhorned beetle Anoplophora chinensis (Coleoptera: Cerambycidae) and its host plants, Castanea mollissima and Castanea seguinii: a predictive analysis using optimized MaxEnt models
Authors: Zhang Liang , Wang Ping , Xie Guanglin , Wang Wenkai 
Published: January 2025

Abstract
The Anoplophora chinensis (Coleoptera: Cerambycidae) (Forster), a serious phytophagous pest threatening Castanea mollissima Blume and Castanea seguinii Dode, poses risks of ecological imbalance, significant economic loss, and increased management difficulties if not properly controlled. This study employs optimized MaxEnt models to analyze the potential distribution areas of A. chinensis and its host plants under current and future climate conditions, identifying their movement pathways and relative dynamics. Results indicate that all models achieved an average AUC value exceeding 0.86, demonstrating low complexity and high predictive accuracy. The key climatic variables influencing the geographic distribution of A. chinensis and its host plants include temperature and moisture-related bioclimatic variables such as mean diurnal range, minimum temp of coldest month, mean temp of wettest quarter, annual precipitation, precipitation of driest month, and precipitation seasonality. Under both current and future conditions, these 3 species are primarily distributed in the southwestern regions of China. Notably, the suitable growth area for all 3 species shows varying degrees of increase. Additionally, C. mollissima and C. seguinii exhibit a trend of eastward displacement in response to climate change. Overall, the findings provide significant practical value for the monitoring, early warning, and targeted control strategies for A. chinensis. Furthermore, these results offer a basis for timely conservation strategies to mitigate the potential impacts of climate change.
Chlorhexidine gluconate application, diabetes, revision surgery, and extended operative time increase risk for penile implant infection
Authors: Helo Sevann , Bonakdar Hashemi Milad , Ziegelmann Matthew J , Lybbert Daniel T , Piraino Javier , Guillen Lozoya Andres H , Köhler Tobias S 
Published: January 2025

Abstract

Background
Chlorhexidine gluconate (CHG) (0.05%) has recently been suggested as a dip and irrigation solution at time of inflatable penile prosthesis (IPP) surgery.

Aim
This study evaluated infection rates before and after implementing CHG protocol while investigating concurrent risk factors contributing to post operative infections.

Methods
A retrospective, consecutive cohort study was performed that included patients who underwent insertion of a Coloplast Titan IPP including both virgin and revision cases between 2021 and 2024. Cases performed from January 2021 to August 2022 utilized rifampin/gentamicin for dip and vancomycin/gentamicin for irrigation (ABX), whereas those from October 2022 to May 2024 utilized CHG for both dip and irrigation. Perioperative risk factors including dip and irrigation solution used at time of surgery were compared between groups.

Outcomes
We defined the incidence of postoperative infection and risk factors associated with infection in each group.

Results
The incidence of infection was significantly higher in the 0.05% CHG group (13/377) compared to the ABX group (0/320) (P &lt; .001). When analyzed separately by subgroup, virgin cases treated with CHG for dip and irrigation demonstrated a significantly higher infection rate (7/315) compared to those in the ABX group (0/280) (P = .012). Similarly, in revision cases, the CHG group also exhibited a significantly higher infection rate (0/40) than the ABX group (6/62) (P = .043).
Univariable analysis of the CHG cohort identified three significant risk factors for infection: diabetes mellitus (DM), extended operative time (OP), and revision surgery (P = .003, .001, and &lt; .001, respectively). Multivariable regression analysis revealed that patients with DM had a 5.7-fold increased risk of infection (OR: 5.70, P = .004), while those undergoing revision surgery faced a 5.3-fold higher risk (OR: 5.26, P = .004). Additionally, each minute increase in OP was associated with a 1% higher infection risk (OR: 1.01 per minute, P = .007). These associations remained significant after adjusting for all variables in the model.

Clinical Implications
Prosthetic surgeons should be cautious about adopting 0.05% CHG for both dip and irrigation in the absence of strong clinical evidence demonstrating its non-inferiority to antibiotic solutions.

Strengths and Limitations
This is the first clinical study reporting infection rates after IPP surgery using 0.05% CHG for both dip and irrigation. While retrospective and non-randomized, we present a relatively large sample size of patients.

Conclusions
Our findings identify four risk factors for penile prosthesis infection: usage of the 0.05% CHG solution for dip and irrigation solution of Coloplast hydrophilic-coated devices, DM, revision surgery, and extended OP.
Combining REBOUND and MESA: dynamical evolution of planets orbiting interacting binaries
Authors: Xing Zepei , Torres Santiago , Götberg Ylva , Trani Alessandro A , Korol Valeriya , Cuadra Jorge 
Published: January 2025

ABSTRACT
Although planets have been found orbiting binary systems, whether they can survive binary interactions is debated. While the tightest-orbit binaries should host the most dynamically stable and long-lived circumbinary planetary systems, they are also the systems that are expected to experience mass transfer, common envelope evolution, or stellar mergers. In this study, we explore the effect of stable non-conservative mass transfer on the dynamical evolution of circumbinary planets. We present a new script that seamlessly integrates binary evolution data from the 1D binary stellar evolution code mesa into the N-body simulation code rebound. This integration framework enables a comprehensive examination of the dynamical evolution of circumbinary planets orbiting mass-transferring binaries, while simultaneously accounting for the detailed stellar structure evolution. In addition, we introduce a recalibration method to mitigate numerical errors from updates of binary properties during the system’s dynamical evolution. We construct a reference binary model in which a $2.21\, \mathrm{ M}_\odot$ star loses its hydrogen-rich envelope through non-conservative mass transfer to the $1.76\, \mathrm{ M}_\odot$ companion star, creating a $0.38\, \mathrm{ M}_\odot$ subdwarf. We find the tightest stable semimajor axis for circumbinary planets to be $\simeq 2.5$ times the binary separation after mass transfer. Accounting for tides by using the interior stellar structure, we find that tidal effects become apparent after the rapid mass transfer phase and start to fade away during the latter stage of the slow mass transfer phase. Our research provides a new framework for exploring circumbinary planet dynamics in interacting binary systems.