bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Familial Appendiceal Neuroendocrine Tumor
Authors: Ghattas Souad , Hadeer Ribal Aby , Maalouf Hani , Al Bitar Jad , Younes Ahmad , Rahban Hind , El Rassi Ziad 
Published: August 2023

ABSTRACT
The risk of developing appendiceal neuroendocrine tumor (aNET) may be attributed to multiple factors. A familial clustering is found in less than 1% of the cases. We report the case of a 25-year-old woman who initially presented with a clinical presentation of acute appendicitis and was subsequently diagnosed with aNET by histopathological examination after an emergency appendectomy. While revealing the result to the patient, she was found to have a positive family history of appendiceal carcinoid tumor. Although rare and only found in 1% of the cases, aNET found in family history should raise the suspicion of neuroendocrine tumors in other family members.
Ischemic Colitis Due to Idiopathic Myointimal Hyperplasia of the Mesenteric Veins
Authors: Noujaim Michael G. , Tang Helen , Kalisz Kevin , Iranzad Natasha , Wild Daniel 
Published: August 2023

ABSTRACT
Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a rare and poorly understood noninflammatory ischemic colitis. First reported by Genta and Haggitt in 1991, the disease typically presents with chronic abdominal pain, weight loss, and diarrhea with or without hematochezia in middle-aged men. IMHMV is frequently misdiagnosed as an inflammatory bowel disease. The pathophysiology of IMHMV involves the proliferation of the intimal smooth muscle in mesenteric veins leading to bowel ischemia. The etiology of this process remains unknown. There are no good medical therapies for IMHMV, and surgical resection, a curative intervention, is typically required to make the diagnosis. We present the case of a 66-year-old man with IMHMV diagnosed with endoscopic biopsies.
Topology of tropical moduli spaces of weighted stable curves in higher genus
Authors: Kannan Siddarth , Li Shiyue , Serpente Stefano , He Yun Claudia 
Published: August 2023

Abstract
We study the topology of moduli spaces of weighted stable tropical curves Δg

,w
with fixed genus and unit volume. The space Δg

,w
arises as the dual complex of the divisor of singular curves in Hassett’s moduli space M
g

,w
of weighted stable curves. When the genus is positive, we show that Δg

,w
is simply connected for any choice of weight vector w. We also give a formula for the Euler characteristic of Δg

,w
in terms of the combinatorics of the weight vector.
Non-local gradients in bounded domains motivated by continuum mechanics: Fundamental theorem of calculus and embeddings
Authors: Bellido José Carlos , Cueto Javier , Mora-Corral Carlos 
Published: August 2023

Abstract
In this article, we develop a new set of results based on a non-local gradient jointly inspired by the Riesz

s

s

-fractional gradient and peridynamics, in the sense that its integration domain depends on a ball of radius

δ
>
0

\delta \gt 0

(horizon of interaction among particles, in the terminology of peridynamics), while keeping at the same time the singularity of the Riesz potential in its integration kernel. Accordingly, we define a functional space suitable for non-local models in calculus of variations and partial differential equations. Our motivation is to develop the proper functional analysis framework to tackle non-local models in continuum mechanics, which requires working with bounded domains, while retaining the good mathematical properties of Riesz

s

s

-fractional gradients. This functional space is defined consistently with Sobolev and Bessel fractional ones: we consider the closure of smooth functions under the natural norm obtained as the sum of the

L

p

{L}^{p}

norms of the function and its non-local gradient. Among the results showed in this investigation, we highlight a non-local version of the fundamental theorem of calculus (namely, a representation formula where a function can be recovered from its non-local gradient), which allows us to prove inequalities in the spirit of Poincaré, Morrey, Trudinger, and Hardy as well as the corresponding compact embeddings. These results are enough to show the existence of minimizers of general energy functionals under the assumption of convexity. Equilibrium conditions in this non-local situation are also established, and those can be viewed as a new class of non-local partial differential equations in bounded domains.
Assessing OpenStreetMap roads fitness-for-use for disaster risk assessment in developing countries: The case of Burundi
Authors: Campalani Piero , Pittore Massimiliano , Renner Kathrin 
Published: August 2023

AbstractEvidence shows how disasters caused by extreme weather events are surely becoming more frequent at all latitudes, and are definitely representing an ever-growing risk in the floods- and landslides-prone territory of Burundi. The still present inequalities of its society and the vulnerable economy make this African country a very relevant and particularly complex case for hazards risk management. A fundamental step in this task is to correctly map the so-called exposure elements to risk, which most notably comprise the population and households, the critical infrastructure, and the transportation network. In this article, we assess the quality of the OpenStreetMap (OSM) roads database in Burundi at national level, with a perspective in its fitness-for-use in the assistance for disaster risk mitigation purposes, which were adopted in the context of a recent multi-hazards risk assessment and mapping exercise on behalf of the International Organisation for Migration. Despite not touching all aspects of volunteered geographic information data quality that are commonly found in literature for a comprehensive assessment, we believe the information provided in this study can be of help for stakeholders in their decision to use the OSM dataset in an otherwise data-scarce area.
Avoiding stress on non-lexical material in nouns and verbs: predictable verb prosody in Serbo-Croatian stress standard varieties
Authors: Simonović Marko , Kager René 
Published: August 2023

Abstract
We consider two asymmetries reported in the literature on word prosodic systems: the tendency to allow more prosodic contrast in nouns than in verbs and the tendency to avoid stress on functional material. We focus on the interaction between these two tendencies and propose a formal mechanism to handle this interaction couched in Optimality Theory. In a case study on a group of standard Serbo-Croatian varieties that have predictable stress in verbs but contrastive stress in nouns, we develop an analysis of predictable and morphologically conditioned stress assignment. Our analysis features a family of constraints militating against stress on non-lexical material on three different levels: stress on inflection proper (
*Infl-Stress-1), stress on non-lexical material in the locality domain of inflection (
*Infl-Stress-2), and stress on non-lexical material altogether (
*Infl-Stress-3). Analyzing a class of prosodically exceptional denominal and borrowed verbs, we show that lexical-category effects exist between and within categories: denominal verbs allow exceptional preservation of nominal stress, which leads to additional prosodic contrast in this class of verbs. Finally, we explore the option of subsuming exceptionally contrast-preserving borrowed verbs under denominal verbs, offering arguments in favor of the hotly debated view from the literature that verbs are universally borrowed as denominal.
Effect of Cu addition on microstructure and corrosion behavior of Al–15Mg2Si composite
Authors: Hesami Leila , Taghiabadi Reza , Ghoncheh Mohammad Hossein , Emami Mohammad , Saghafi Yazdi Morteza 
Published: August 2023

Abstract
The Cu effect on the microstructure and corrosion resistance of Al–15Mg2Si composites was studied. The results showed that Cu addition decreased the average size of primary Mg2Si (Mg2SiP) particles, changed the hopper-like Mg2SiP particles to polyhedrals, and caused the formation of θ-Al2Cu and Q-Al5Mg8Si6Cu2 compounds in the composite matrix. According to the image analysis results, increasing the Cu content from 0.01 to 5 wt% halved the average size of Mg2SiP particles, increased their fraction by about 40 %, and increased the composite porosity content. The electrochemical impedance spectroscopy showed that adding 5 wt% of Cu resulted in an increase of about 3.7 times in the corrosion resistance as compared to Al–15Mg2Si composite. The beneficial effects of Cu were also confirmed by the potentiodynamic polarization experiments. Cu addition seems to promote less intense general corrosion than the base alloy’s localized attack.
Hyperpolarization-Activated Cation Channels Shape the Spiking Frequency Preference of Human Cortical Layer 5 Pyramidal Neurons
Authors: Inibhunu Happy , Moradi Chameh Homeira , Skinner Frances , Rich Scott , Valiante Taufik A. 
Published: August 2023

AbstractDiscerning the contribution of specific ionic currents to complex neuronal dynamics is a difficult, but important, task. This challenge is exacerbated in the human setting, although the widely characterized uniqueness of the human brain compared with preclinical models necessitates the direct study of human neurons. Neuronal spiking frequency preference is of particular interest given its role in rhythm generation and signal transmission in cortical circuits. Here, we combine the frequency-dependent gain (FDG), a measure of spiking frequency preference, and novelin silicoanalyses to dissect the contributions of individual ionic currents to the suprathreshold features of human layer 5 (L5) neurons captured by the FDG. We confirm that a contemporary model of such a neuron, primarily constrained to capture subthreshold activity driven by the hyperpolarization-activated cyclic nucleotide gated (h-) current, replicates key features of thein vitroFDG both with and without h-current activity. With the model confirmed as a viable approximation of the biophysical features of interest, we applied new analysis techniques to quantify the activity of each modeled ionic current in the moments before spiking, revealing unique dynamics of the h-current. These findings motivated patch-clamp recordings in analogous rodent neurons to characterize their FDG, which confirmed that a biophysically detailed model of these neurons captures key interspecies differences in the FDG. These differences are correlated with distinct contributions of the h-current to neuronal activity. Together, this interdisciplinary and multispecies study provides new insights directly relating the dynamics of the h-current to suprathreshold spiking frequency preference in human L5 neurons.
SISTEMAS INTEGRADOS DE GESTIÓN
Authors: Mahecha Lagos Nancy Constanza , Gómez Luisa Fernanda , Moreno Rodriguez Ingrid Carolina , Londoño Restrepo Diana Catalina , Camacho Camacho Hernando 
Published: August 2023

Los Sistemas de Gestión se han constituido en el referente más utilizado y confiable en las prácticas empresariales para cumplir con las expectativas de los diferentes grupos de interés, proveen confianza y mejoran la aceptación de los clientes. Sin embargo, la implementación de varios sistemas de manera independiente ha abocado a las organizaciones a perder su eficiencia en la gestión de sistemas, situación que ha impulsado el desarrollo de propuestas metodológicas de integración de sistemas. Esta investigación tiene como objetivo realizar una revisión de los aspectos que han marcado la evolución de la integración de los sistemas de gestión, profundizando en la comprensión de las dimensiones base de las metodologías de integración y a partir de estas, presenta un análisis comparativo de los principales metodologías encontradas. La investigación es de tipo cualitativo, utilizando el método de revisión de la literatura. En la etapa de búsqueda de información se identificaron los principales artículos de estado del arte donde se describe la evolución y características del proceso de integración de sistemas de gestión. La segunda etapa consistió en una revisión a profundidad, interpretación y análisis de las principales dimensiones y metodologías de integración identificadas. Los resultados de la investigación permitieron describir el proceso de integración a partir de sus beneficios, motivadores y dificultades; identificar cuatro dimensiones conceptuales del proceso de integración: estratégica, metodológica, nivel de integración e integración de auditorías internas y comparar los principales referentes de integración: PAS 99, UNE 66177 y Handbook, ISO 9001, IUMS.
The Effect of Different Concentrations of Bee Venom on Kidney Tissue of Albino Male Rats Rattus
Authors: Ubaid Jenan Mohammed , Hassan Walaa Salih 
Published: August 2023

In this study, 60 males of albino rats (Rattus rattus) were tested to study the effect of BV on kidney tissue at two doses of 10 and 40 µg/kg and two times after 10 and 15 days. The sample included 40 rats divided into two groups; 20 rats for each group. These groups were injected intraperitoneally according to the mentioned periods and were considered as a control group. The results exhibited renal tubule dilation and slight atrophy of glomerular tuft in the kidneys of rats treated with 10 µg/kg for 10 days compared to kidneys in the control treatment. Furthermore, 10 µg/kg treatment for 15 days has caused renal tubule dilation and degeneration with cytoplasmic vacuolation. Our findings also showed a slight atrophy of the glomerular tuft as well as a reduction in the number of glomeruli in this subcapsular area. The results also indicate regeneration of kidney tubules in rats given 40 µg/kg for 10 days. Meanwhile, sections of the kidney for rats that were given 40 µg/kg for 15 days exhibited a slight atrophy of glomerular tuft hypertrophied tubular epithelial cells.
Unmanned Aerial Vehicle Aeromagnetic Analyses Reveal the Causative Faults and Seismogenic Mechanism of the 2021 Ms 6.0 Luxian, China, Earthquake
Authors: Zhao Junhao , Jiao Liguo , Lei Yu , Tu Jiyao 
Published: August 2023

Abstract
On 16 September 2021, an Ms 6.0 earthquake occurred in Luxian, Sichuan, China, breaking the historical record of no earthquake with magnitude ≥ M 6 along the Huaying Mountain fault belt. The regional geological structure is primarily controlled by the northeast-striking fault belt, but the long axis of the isoseismic line, distribution of early aftershocks and coseismic rupture plane all strike northwest, posing challenges to the seismogenic mechanism. To investigate this, we conducted a 400  km2 unmanned aerial vehicle (UAV) aeromagnetic survey near the epicenter, with a line spacing of 1 km. Through aeromagnetic analyses, combined with the spatial distribution of relocated foreshocks and aftershocks, we outline potential basement causative faults and a change in the structural trend between the shallow and deep portions of the seismic zone. We conjecture that the Luxian earthquake was triggered by the hydrofracturing-driven reactivation of a pre-existing northwest-striking and southwest-dipping basement fault, of which the upward propagation induced extrusion and dislocation at the hypocenter within the sedimentary layer. The special structural configurations for the focal area could contribute to the stress concentration and occurrence of large earthquakes.
IN VITRO ANTIBACTERIAL ACTIVITY OF EUCALYPTUS (Melaleuca leucadendra) OIL AGAINST METHICILLIN-RESISTANT Staphylococcus aureus (MRSA)
Authors: Constantia Lidwina Targanski  , Wiwin Retnowati  , Mohammad Fathul Qorib  , Manik Retno Wahyunitisari  , Wilda Mahdani  
Published: August 2023

Highlights

The use of eucalyptus oil is natural and risk-free. It has a lengthy history of use as a traditional medicine in Asia, including Indonesia.
It has been demonstrated that eucalyptus oil possesses antibacterial activity against MRSA, and this activity was controlled by the oil's concentration.

Abstract
Background: Eucalyptus (Melaleuca leucadendra) oil is used by Indonesians as an herbal medicine. Eucalyptus containing 1,8-cineol at 72.30% is expected to be used as an antibacterial. Objective: The study aimed to assess the antibacterial activity of eucalyptus oil against Methicillin-resistant Staphylococcus aureus (MRSA) bacteria in vitro. Material and Method: The materials used were eucalyptus oil (M. leucadendra) in various concentrations with ethyl acetate as solvent. The research method used was the agar-well diffusion assay. The MRSA was suspended to 0.5 McFarland turbidity. The MRSA suspension was thoroughly swabbed onto the surface of the Mueller-Hinton agar plate. The wells were made with a diameter of 0.6 mm on Muller-Hinton agar aseptically and 100 µl of eucalyptus oil was put into the well using a micropipette and incubated for 24 hours at 37°C. The diameter of the inhibition zone was measured with a caliper. Statistical analysis using the SPSS software edition 23. Result: Eucalyptus oil solution starting from a concentration of 10% to 100% had an antibacterial response, which could be seen by the formation of a bacterial inhibition zone around the eucalyptus oil (M. leucadendra) wells. The inhibition ability of eucalyptus oil against MRSA bacteria was greatest at a concentration of 90% with an inhibition zone of 31.26 mm. It was found that the concentration of eucalyptus oil affected the diameter of the bacterial inhibition area. Conclusion: Eucalyptus oil has been shown to have antibacterial activity against MRSA and was influenced by the concentration of the oil.
TUBERCULIN SKIN TEST AND INTERFERON-γ RELEASE ASSAY ON THE DIAGNOSIS OF TUBERCULOUS SPONDYLITIS
Authors: Hadid Tsabita , Faris Muhammad , Betty Agustina Tambunan  
Published: August 2023

Highlights

TST and IGRA have a significant correlation with the diagnosis of patients with Tuberculous Spondylitis.
Various factors may affect the results of TST and IGRA. Thus, the use of TST and IGRA can be adjusted according to the condition of the hospital, the availability of diagnostic tools, the health worker’s physical examination results, and the patient's medical history.

Abstract
Background: Tuberculous spondylitis or Pott’s disease is extrapulmonary tuberculosis that is still a concern to health workers because of the broad spectrum of its clinical symptoms. Delay in diagnosis is very common in this disease. Therefore, its diagnostic tool needs to be thoroughly reviewed to determine its effectiveness. The diagnostic tools studied in this study were Tuberculin Skin Test (TST) and Interferon-γ Release Assay (IGRA). Objective: To analyze the role of TST and IGRA as diagnostic tools for the diagnosis of tuberculous spondylitis. Material and Method: This study used a systematic review method to analyze topic-related kinds of literature written in English and Indonesian found on PubMed, Scopus, ProQuest, and Web of Science databases. The literature screening process was carried out based on the PRISMA 2020 Guidelines. Result: Sixteen types of literature were included for a total of 116 patients. TST was detected positive in 45 (63%) and negative in 21 (30%) of a total of 66 patients with Pott’s disease. IGRA was detected positive in 51 (77%), negative in 8 (12%), and indeterminate in 2 (3%) of a total of 61 patients with Pott’s disease. Conclusion: TST and IGRA results significantly correlate with the diagnosis of tuberculous spondylitis. Both tests are still relevant for use in the diagnosis of the disease. IGRA and TST are used according to the needs of health workers and patients’ health backgrounds.
Efektivitas Patch Transdermal Ekstrak Etanol Daun Insulin (Smallanthus sonchifolius) Terhadap Kadar Glukosa Darah dan Histopatologi Pankreas Tikus Putih
Authors: Wijayanti Ni Putu Pirna , Hendriati Lucia , Hamid Iwan Sahrial , Widodo Teguh , Kuncorojakti Suryo 
Published: August 2023

<p><span lang="EN-US">Diabetes melitus adalah penyakit metabolik yang ditandai dengan hiperglikemia akibat kelainan sekresi insulin, kerja insulin atau keduanya. Salah satu permasalahan yang dihadapi dalam pengobatan pasien diabetes adalah kepatuhan terhadap terapi obat. Daun insulin (<em>Smallantus sonchifolius</em>) memiliki efek menurunkan kadar gula darah, tetapi pada penggunaan jangka panjang per oral dapat menimbulkan efek samping terbentuknya lesi ginjal. Rute penghantaran alternatif untuk meningkatkan kepatuhan pasien dan menurunkan efek samping adalah penghantaran transdermal. Tujuan penelitian ini untuk mengetahui efek <em>patch</em> transdermal ekstrak etanol daun insulin terhadap kadar gula darah dan gambaran histopatologi pankreas tikus. Tikus putih yang telah diinduksi aloksan dibagi menjadi 6 kelompok perlakuan yaitu: kontrol positif (metformin per oral), <em>patch</em> tanpa ekstrak daun insulin dengan peningkat penetrasi <em>Tween 60</em>, <em>patch</em> tanpa ekstrak daun insulin dengan peningkat penetrasi <em>Span 80</em>, <em>patch</em> ekstrak daun insulin dengan <em>Tween 60</em>, dan <em>patch</em> ekstrak daun insulin dengan <em>Span 80</em>. Dosis ekstrak etanol daun insulin yang digunakan sebesar 400 mg/kgBB. Pengamatan terhadap kadar gula darah dan gambaran histopatologi pankreas dilakukan selama 14 hari. Analisis data menggunakan Anova satu jalan. Penggunaan <em>patch</em> transdermal ekstrak daun insulin menurunkan gula darah tikus sejak hari ke-1 dan pada hari ke-9 menghasilkan kadar gula darah tikus lebih rendah dibandingkan metformin per oral. Penambahan peningkat penetrasi <em>Tween 60</em> dan <em>Span 80</em> meningkatkan penurunan kadar gula darah. Hasil yang sama juga didapatkan pada parameter gambaran histopatologi pankreas tikus. Berdasar hasil penelitian, pemberian <em>patch</em> transdermal ekstrak etanol daun insulin (<em>Smallanthus sonchifolius</em>) dapat menurunkan kadar glukosa darah dan mempengaruhi gambaran hispatologi pankreas pada tikus putih. </span></p>
Assessment of the Model for Calculating the Mass of the Coolant of the First Circuit of the Nuclear Power Plant with VVER-1000 Units
Authors: Koba Kostyantyn , Lys Stepan , Kravets Taras , Yurasova Oksana , Galyanchuk Igor 
Published: August 2023

During the design of the nuclear power plant with VVER-1000 units, which today form the basis of the nuclear power industry of Ukraine, the development of information and computing systems (IСS) was insufficient to solve many tasks due to the small capacities of computing systems. Currently, newer ones, the computing capabilities of which are thousands of times greater than their predecessors, have replaced many IСS. IСS download currently does not exceed 1 %...2 %, this is due to the use of simplified models. A model is proposed that adequately describes the considered processes and can work in real time, which significantly increases the range of use. It has a small computational effort, so it can be implemented on the existing IСS. A method has been proposed which, as a result of testing, has shown its effectiveness and, in some cases, higher accuracy and resolution.