bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlación entre los niveles elevados del índice neutrófilo/linfocito y el tiempo de estancia hospitalaria de los pacientes con síntomas moderados por COVID-19
Authors: Rueda Lara Nataly Alejandra , Sánchez Salazar Andrés Antonio , Rodríguez Cifuentes Luis Arturo 
Published: March 2023

Introducción: Desde el 2019 han surgido casos del síndrome respiratorio agudo severo causado por el coronavirus 2 (SARS-CoV-2), conocido como COVID-19, en Wuhan, China. Esta infección se expandió a todo el mundo, siendo reconocida como una pandemia por la OMS el 11 de marzo del 2020. La mayoría de los casos presentan síntomas leves como, fiebre de bajo grado y tos seca, sin embargo, la enfermedad puede llegar a ser fatal. Pacientes con características de riesgo presentan mayor riesgo de infección y de peor pronóstico. Los pacientes con enfermedad severa pueden progresar rápidamente a fallo respiratorio agudo, síndrome de dificultad respiratoria agudo, acidosis metabólica, coagulopatía y choque séptico. Objetivo: El propósito de este estudio fue evaluar la relación entre los niveles del índice neutrófilo/linfocito y el desenlace de la enfermedad (días de estancia hospitalaria, ingreso a intensivo y/o mortalidad) de los pacientes con síntomas moderados por COVID 19 en el periodo de junio-septiembre 2020. Metodología: Se utilizaron datos de 406 pacientes de la base de datos del IGSS, que fueron clasificados con sintomatología moderada. De estos se recolectaron datos generales, valores de laboratorio al ingreso y desenlace (días de estancia hospitalaria, ingreso a intensivo y/o mortalidad). Resultados: De los 406, el 61% fueron diagnosticados por prueba de PCR y 39% por prueba de antígeno. Las comorbilidades más frecuentes fueron: hipertensión arterial, en 33% (132) de los pacientes, diabetes mellitus 24% (98), y enfermedad renal crónica 12% (49). La media del índice neutrófilo/linfocito (N/L) en el estudio fue de 9.22, mayor a lo reportado por la literatura como normal que es 1.65. Los pacientes con traslado a UTIA contaban con un índice N/L promedio en 14.83. Conclusión: Existe una leve, pero significativa correlación entre el tiempo de estancia hospitalaria y el índice neutrófilo/linfocito, con un valor p de 0.03671 y una r de Spearman de 0.10. Además, existe una diferencia significativa en la distribución del índice N/L en pacientes que fueron trasladados a la UTIA (p = 0.002878).
Impact du management ministériel de la réforme LMD sur sa réussite
Authors: Chabchoub Ahmed 
Published: March 2023

Le LMD ( ou Processus de Bologne) est une réforme pédagogique et structurelle suggérée par l’Union Européenne à ses partenaires du Sud (notamment les pays du Maghreb) pour mettre leur système universitaire au niveau de la norme Européenne (Chabchoub, 2006). Entrée en vigueur à partir de 2004, pour la Tunisie, cette réforme devait réaliser deux innovations majeures :
- Transformer la structure des études universitaires (souvent hétéroclites) en 3, 5, 8 à savoir, 3 années pour la Licence, 5 pour le Master et 8 pour le Doctorat. Cette structure devait se généraliser sur tous les régimes d’étude, sauf pour les études médicales.
- Introduire à l’occasion une réforme pédagogique profonde en :
- Invitant les professeurs à enseigner autrement que par les méthodes magistrales,
- Encourageant les étudiants à apprendre autrement,
- Incitant les enseignant à évaluer leurs étudiants autrement que par le biais de la restitution des connaissances apprises par cœur, dans la plupart des cas (Circulaire organique du 25/9/2003).
Mais comme le souligne Cros (2006), la réussite d’une réforme éducative dépend souvent de la manière dont elle a été managée et conduite. En effet, selon qu’elle soit conduite « Top –Dawn », ou en association étroite avec les parties prenantes (ici les enseignants), une réforme pédagogique peut, soit échouer soit réussir.
Le présent article qui traite de l’Impact du management ministériel de la Réforme LMD sur sa réussite (cas de la Tunise), essaiera de répondre aux deux questions suivantes :
- Comment le Ministère tunisien de l’enseignement supérieur a-t-il conduit la réforme LMD et selon quel style de management ?
- Quel a été l’impact de ce style de management sur la réussite de la dite réforme, 10 ans après ?
Gebelikte intrauterin exitusla sonuçlanan şiddetli trombositopeni ve literatürün gözden geçirilmesi
Authors: KAYACIK GÜNDAY Özlem , EROGLU Hasan 
Published: March 2023

Amaç: Şiddetli trombositopeni ve intrauterin exitus fetusun eşlik ettiği bir gebeliği ve bunun yönetimini literatürü gözden geçirerek sunmayı amaçladık
Olgu sunumu: 21 yaşında, 24 hafta tekil gebeliği olan hasta, bulantı, kusma, burun kanaması şikayeti ile başvurdu. TA: 110/ 70 mmHg, nabız: 85/ dk idi. Herhangi bir obstetrik patoloji saptanmayan hastada, şiddetli trombositopeni (plt: 9000/ uL) saptandı. Hb: 13 g/ dl, ALT: 12 U/ L, AST: 40 U/ L, Albumin: 2,47 g/ dl, kreatinin: 0,83 mg/dl, total biluribin: 0,27 mg/dl idi ve immün trombositopeni ön tanısı ile, 1 Ü aferez ve 1 Ü havuzlanmış trombosit transfüzyonu ve 32 mg/gün prednol tedavisi uygulandı; kontrol plt: 36000/ uL idi. Hastanın 10 gün sonraki kontrolünde, plt: 6000/ uL ve fetal kalp atımı izlenmemesi üzerine, terminasyon kararı verildi. Vital bulgular: TA: 130/ 80, nabız: 98/ dk, ateş: 36 0C idi. Hb:6,7 g/ dl, plt: 6000/ uL, total biluribin 0,88 mg/ dl, ALT: 28 U/ L, AST: 70 U/ L, LDH: 2297 U/L, Haptoglobin
Variability of serum anti-Mullerian hormone level and antral follicle count in an unstimulated menstrual cycle
Authors: DİZDAR Merve , KALE İbrahim , ESEN İlgi , BAYIK Rahime 
Published: March 2023

Aim: To evaluate the variability of anti-Mullerian hormone (AMH) and antral follicle count (AFC) in an unstimulated menstrual cycle.
Materials and Method: The study was designed on 50 women who had regular menstrual cycles and did not have any systemic disease or previous ovarian surgery. Serum AMH levels and antral follicle counts of all participants were evaluated three times in the same menstrual cycle in the early and late follicular phase and luteal phase. To evaluate the intracyclic AMH fluctuation according to age, participants were divided into two groups; younger (
Dung beetles from two sustainable-use protected forests in the Brazilian Amazon
Authors: Carvalho Edrielly C. , Maldaner Maria , Costa-Silva Vinicius , Sehn Heivanice , Franquini Carol , Campos Vinicius , Seba Vinicius , Maia Laís , Vaz-de-Mello Fernando , França Filipe 
Published: March 2023

The Amazon Forest is one of the world's most biodiverse ecosystems and yet its protected areas are understudied concerning insects and other invertebrates. These organisms are essential for tropical forests due to their ecological processes, with some species being very sensitive to habitat disturbances. Dung beetles (Coleoptera, Scarabaeidae, Scarabaeinae) have been used as bioindicators for more than 30 years and were surveyed to assess the insect biodiversity of two sustainable-use forest reserves in the Brazilian Amazon.
We report inventories of dung beetles from two Amazonian forest reserves in Pará State, Brazil: the Tapajós National Forest and the Carajás National Forest. Surveys were carried out with baited-pitfall traps installed in 2010, 2016, 2017 and 2019. We collected a total of 3,772 individuals from 19 genera and 96 species. We highlight the importance of Amazonian protected areas as refugia for insect biodiversity, particularly dung beetles, which contribute to many key ecosystem processes.
Long-Term Safety and Efficacy of Ixekizumab in Patients With Axial Spondyloarthritis: 3-year Data From the COAST Program
Authors: Deodhar Atul , Poddubnyy Denis , Rahman Proton , Ermann Jeorg , Tomita Tetsuya , Bolce Rebeca , Leage Soyi Liu , Kronbergs Andris , Johnson Caroline , Araújo Joana , Leung Ann , van der Heijde Désirée 
Published: March 2023

ObjectiveTo report safety and efficacy of ixekizumab (IXE) from the COAST program at 3 years, including 1 year from the originating studies (COAST-V, COAST-W, and COAST-X), and 2 years from COAST-Y.MethodsIn COAST-Y, patients continued with the dose received at the end of the originating study at week 52: 80 mg IXE either every 4 weeks (Q4W) or every 2 weeks (Q2W). Placebo-treated patients from COAST-X received IXE Q4W in COAST-Y. Starting at week 116 (week 64 of COAST-Y), patients receiving IXE Q4W could be escalated to Q2W. Safety for patients receiving ≥ 1 dose of IXE and efficacy for patients receiving ≥ 1 dose of IXE Q4W was assessed. Data are summarized as observed.ResultsFor the 932 patients who received ≥ 1 dose of IXE (Q2W or Q4W) through 3 years, treatment-emergent adverse events (TEAEs) occurred at an incidence rate (IR) of 38.0 per 100 patient-years (PYs). The most frequently reported were infections (IR 25.7 per 100 PYs) and injection site reactions (IR 7.4 per 100 PYs); the majority of TEAEs were mild or moderate in severity. In total, 7.1% of TEAEs led to discontinuation (IR 3.1 per 100 PYs). All patient groups receiving IXE Q4W assessed through 3 years saw sustained improvements in Ankylosing Spondylitis Disease Activity Score, clinically important improvement, and other efficacy end points.ConclusionThe 3-year safety profile of IXE in the COAST program is consistent with the previously established long-term safety profile. IXE Q4W provided sustained improvement of disease activity in patients who received treatment through 3 years. (ClinicalTrials.gov:NCT02696785[COAST-V],NCT02696798[COAST-W],NCT02757352[COAST-X], andNCT03129100[COAST-Y])
Assessment of the breeding system in the Algerian narrow coastal endemism Anacyclus linearilobus (Anthemideae, Asteraceae)
Authors: Sánchez-Albert Adrián , Torices Rubén , Kaid-Harche Meriem , Álvarez Inés 
Published: March 2023

The breeding system of Anacyclus linearilobus, an annual and endemic species restricted to dune ecosystems of the Algerian coast were assessed through the effect of self-fertilization and intra- and inter-population artificial crosses on the probability of producing viable seeds in 20 individuals from two populations in a common garden. The breeding system was determined for each individual by the self-incompatibility index (ISI). These results were compared with those published for other species of the genus, A. clavatus, A. homogamos and A. valentinus. Results of experimental crosses showed that there was high variation in the female reproductive success between individuals of A. linearilobus, like that found in its sister species, A. valentinus. Unlike the other species in the genus that are self-incompatible, A. linearilobus showed a mixed mating system, with a majority of self-incompatible individuals, others partially self-incompatible and some self-compatible. We argue that this strategy may be related to reproductive assurance in this endemic, annual species whose effective population size has been reduced probably due to individual mating incompatibilities.
Prognostic Utility of a Modified Pediatric Index of Mortality 3 Score Incorporating Nutritional Status: An Observational Study
Authors: Iqbal Zahid Sayeed , Parameswaran Narayanan 
Published: March 2023

Background:
The pediatric index of mortality 3 (PIM 3) score is one of the main scores for predicting mortality risk in pediatric intensive care units (PICUs). However, it does not consider nutritional status in its calculation. The inclusion of the same may improve its performance in developing countries.

Aims:
We aimed to develop a modified PIM 3 score incorporating nutritional status in its calculation. We also aimed to assess the prognostic utility of the modified score and to compare the performance of the modified score with the existing PIM 3 score.

Setting and Design:
The modified score was developed based on retrospective data analysis from a PICU in a tertiary care hospital in South India. Testing the scores was accomplished through a prospective observational study in the same PICU.

Subjects and Methods:
All the parameters required to calculate the PIM 3 score and anthropometric parameters were collected. Then, multivariable logistic regression analysis was performed to obtain coefficients for each variable, and an equation for the modified score was framed. The performance of the modified score was prospectively tested in the PICU and compared with the existing PIM 3 score using standardized mortality ratio (SMR) and area under the receiver operator characteristics (ROC) curve.

Results:
A total of 191 patients were included in the retrospective cohort for developing the modified equation, and the same was tested in 82 patients of the prospective cohort. Out of the 82 patients in the prospective arm, 14 (17%) died in the PICU. Total mortality predicted for the modified and original scores was 15.28 and 9.27, SMR was 0.92 and 1.51 and area under the ROC curve was 0.68 (95% confidence intervals [CI]: 0.48–0.89) and 0.69 (95% CI: 0.49–0.88), respectively.

Conclusions:
While both scores have poor discrimination ability, the modified PIM 3 score has an SMR value closer to one, suggesting better reliability.
Identification of the candidate genes of diagnosing rheumatoid arthritis using the single-cell sequencing technology and T cell subclusters analysis of patients with rheumatoid arthritis
Authors: Liu Yajing , Fan Shaoguang , Meng Shan 
Published: March 2023

Objectives: This study aims to analyze the heterogeneity among different cell types in peripheral blood mononuclear cells (PBMC) in rheumatoid arthritis (RA) patients and to analyze T cell subsets to obtain key genes that may lead to RA.
Materials and methods: The sequencing data of 10,483 cells were obtained from the GEO data platform. The data were filtered and normalized initially and, then, principal component analysis (PCA) and t-Distributed Stochastic Neighbor Embedding (TSNE) cluster analysis were performed using the Seurat package in R language to group the cells, thereby obtaining the T cells. The T cells were subjected to subcluster analysis. The differentially expressed genes (DEGs) in T cell subclusters were obtained, and the hub genes were determined by Gene Ontology (GO) functional enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and protein-protein interaction (PPI) network construction. Finally, the hub genes were validated using other datasets in the GEO data platform.
Results: The PBMC of RA patients were mainly divided into T cells, natural killer (NK) cells, B cells, and monocyte cells. The number of T cells was 4,483, which were further divided into seven clusters. The pseudotime trajectory analysis showed that the differentiation of T cells developed from cluster 0 and cluster 1 to cluster 5 and cluster 6. Through GO, KEGG and PPI analysis, the hub genes were identified. After validation by external data sets, nine genes were identified as candidate genes highly associated with the occurrence of RA, including CD8A, CCL5, GZMB, NKG7, PRF1, GZMH, CCR7, GZMK, and GZMA.
Conclusion: Based on single-cell sequencing analysis, we identified nine candidate genes for diagnosing RA, and validated their diagnostic value for RA patients. Our findings may provide new sights for the diagnosis and treatment of RA.
MiR-30e-5p deficiency exerts an inhibitory effect on inflammation in rheumatoid arthritis via regulating Atl2 expression
Authors: Liu Shanshan , Wang Kai , Li Ju , Liu Yan , Zhang Zhongyuan , Meng Deqian 
Published: March 2023

Objectives: This study aims to investigate the inflammatory effect of the microRNA (miRNA) miR-30e-5p on rheumatoid arthritis (RA) development in RA mice and fibroblast-like synoviocytes (FLS).
Materials and methods: MiR-30e-5p and atlastin GTPase 2 (Atl2) expression in RA tissues and RA-FLS was evaluated using real-time quantitative polymerase chain reaction. The function of miR-30e-5p in inflammation of RA mice and RA-FLS was analyzed by enzyme-linked immunosorbent assay (ELISA) and Western blotting. 5-ethynyl-2ˊ-deoxyuridine (EdU) assay was used to detect RA-FLS proliferation. Luciferase reporter assay was to confirm the interaction between miR-30e-5p and Atl2.
Results: MiR-30e-5p expression was upregulated in the tissues from RA mice. Silencing miR-30e-5p alleviated inflammation in RA mice and RA-FLS. MiR-30e-5p negatively modulated Atl2 expression. Atl2 knockdown exerted a proinflammatory effect on RA-FLS. Atl2 knockdown rescued the inhibitory effect of miR-30e-5p knockdown on proliferation and inflammatory response of RA-FLS.
Conclusion: MiR-30e-5p knockdown inhibited the inflammatory response in RA mice and RA-FLS through Atl2.
The Performance of the Solar Panel Installation Configuration in the Face of Lighting Changes
Authors: Asnil Asnil , Hazman Hanif 
Published: March 2023

Partial shadow is one of the factors that affect the efficiency of solar panels, besides temperature and humidity. Partial shade reduces the performance of the solar panel and gives rise to some local maximums. One effort to reduce the negative effects of this partial shade is to reconfigure the installation of solar panels. This study aims to examine the effect of partial shadows with various solar panel configurations. The 3x3 system was used in this study, with several configurations namely Series Parallel (SP), Total Cross Tied (TCT), Triple Tied (TT), Bridge Link (BL), and Honey Comb (HC). The test results are monitored through a Visual Basic-based interface that displays data in graphical form. The test results show that the configuration that produces the most energy is TCT followed by TT, BL, HC and SP which produces the lowest energy from all tests.
Bayangan parsial merupakan salah satu faktor yang mempengaruhi efisiensi dari panel surya, disamping suhu dan kelembapan. Bayangan parsial membuat kinerja panel surya tidak maksimal dan menimbulkan beberapa titik maksimum lokal. Salah satu upaya untuk mengurangi efek negatif dari bayangan parsial ini adalah dengan melakukan rekonfigurasi pemasangan panel surya. Penelitian ini bertujuan untuk melihat pengaruh bayangan parsial dengan berbagai konfigurasi pemasangan panel surya. Sistem yang digunakan adalah 3x3 dengan konfigurasi Series Parallel (SP), Total Cross Tied (TCT), Triple Tied (TT), Bridge Link (BL), dan Honey Comb (HC). Hasil pengujian dimonitoring melalui interface berbasis Visual Basic yang menampilkan data dalam bentuk grafik. Hasil pengujian menunjukkan konfigurasi yang menghasilkan energi paling besar adalah TCT kemudian diikuti oleh TT, BL, HC dan SP menghasilkan energi yang paling rendah dari semua pengujian.
Risk Management Analysis in Container Yard Development Projects in Eastern Indonesia
Authors: Muttaqin Prafajar Suksessanno , Novitasari Nia , Setyawan Erlangga Bayu 
Published: March 2023

A container yard is a place for storing containers, a place for cleaning, and repairs, as well as a place for carrying out container surveys. Currently planning the construction of a container yard in Eastern Indonesia is being carried out. In its construction, a container yard requires large investment costs due to many factors such as the difficulty and high cost of transporting raw materials, permits that require planning, to the need for proper business processes in order to provide smooth operational activities by minimizing risk. The purpose of this study is to identify the risks and causes of risks involved in the container depot development project in Eastern Indonesia using the quantitative risk assessment (QRA) method, so as to provide the most influential risk management recommendations. The research succeeded in identifying 24 risks and 24 causes of risk. Furthermore, from the calculation results, it was concluded that there were 9 most influential risks.
Depo kontainer merupakan tempat penyimpanan kontainer, tempat pembersihan, perbaikan, serta tempat untuk pelaksanaan survei kontainer. Saat ini sedang dilakukan perencanaan pembangunan depo kontainer di Indonesia Timur. Dalam pembangunanya, depo kontainer membutuhkan biaya investasi yang besar yang disebabkan banyak faktor seperti sulit dan tingginya biaya transportasi bahan baku, perizinan yang membutuhkan perencanaan, hingga kebutuhan akan adanya proses bisnis yang tepat agar dapat memberikan kelancaran pada aktivitas operasional dengan meminimasi risiko. Tujuan penelitian ini adalah mengindenfitikasi risiko dan penyebab risiko yang terdapat pada proyek pembangunan depo kontainer di Indonesia Timur dengan metode quantitative risk assessment (QRA), sehingga dapat memberikan usulan penanganan risiko yang paling berpengaruh. Penelitian berhasil mengidentifikasi 24 risiko dan 24 penyebab risiko. Lebih lanjut dari hasil perhitungan disimpulkan ada 9 risiko paling berpengaruh.
The Role Of Motivation In Mediating Culture Work And The Work Concept Of Work From Home (Wfh) On Employee Performance Post Pandemic Covid- 19 At Pt Tasblock Industry Indonesia
Authors: Sustenance Ananda Lubis Fazar , Syaifuddin Syaifuddin 
Published: March 2023

Work culture is something, a habit that is carried out in an activity that is impossible to change quickly a set of behaviors, feelings and psychological frameworks that are deeply internalized and shared by members of the organization ”. Osborn and Plastrik (2002:252 ) A person who feels his life satisfaction is fulfilled, then carrying out his work he enjoys his experiences which are accompanied by the level of joy Alston & Dudley (in Hurlock, 1980), where life satisfaction has brought an employee to work with high awareness and motivation for their duties and responsibilities. This research was conducted to prove the most appropriate model in influencing employee performance through motivation, Work from Home (WFH) Culture work Research approach using Structural Equation Modeling (SEM). of the 117 population of employees and taken 54 using the PT. Indonesian Industrial Tasblock.
. Collecting data using a questionnaire is a way for researchers to obtain research data. Results This study shows that the Work and Work From Home curriculum directly has a significant effect on Employee Performance and the Work and Work From Home curriculum affects Employee Performance. Finally, indirectly, motivation has a significant effect in mediating the Curtur of Work and Work From Home on Employee Performance.
Phytochemical Screening and Formulation of Hand Sanitizer Gel Preparations from Temu Hitam Rhizome Extract (Curcuma aeruginosa Roxb)
Authors: Sari Rika Puspita , Efa Harnis Zola , Irmayanti Harahap Nina 
Published: March 2023

Temu Hitam (Curcuma aeruginosa Roxb) is one of the most widely grown plants in Indonesia at an altitude of 400–750 m asl and contains many secondary metabolites, including flavonoids, alkaloids, saponins, tannins, and curcuminoids, which in the test had antibacterial activity and growth inhibitors. worm larvae in the gastrointestinal tract and the effect of increasing the body's immunity The purpose of this study was to identify the content of secondary metabolites contained in the rhizome of black turmeric, which would then be formulated into gel hand sanitizer preparations. Secondary metabolite testing was conducted on alkaloids, flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides. Three different hand sanitizer gel formulations were created using different extract concentrations, 5%, 10%, and 15%. Evaluation tests were then run on the preparations, including stability, organoleptic, homogeneity, pH, and dispersion tests. Alkaloids, flavonoids, tannins, saponins, and steroids were found in the temu hitam rhizome, according to the results of secondary metabolite testing. The dosage form was semi-solid, had a light brown to blackish brown hue, a distinct spice scent, was homogeneously prepared, and had a pH of 7.0, according to the examination of the formulation results 4,1 ± 0,17; 4,4 ± 0,19; 4,9 ± 0,08; 4,9 ± 0,09, viscosity 2378 ± 209,9; 3340 ± 220,7; 4509 ± 285,6; 4881 ± 276,7; and spreadability test 5; 6,2; 5,4; 4,9 cm . The conclusion of this study is that the results of the phytochemical screening of simplicia and the ethanolic extract of the Temu Hitam rhizome showed positive results, containing secondary metabolites of alkaloids, flavonoids, tannins, saponins, glycosides, and steroids/triterpenoids that can be formulated into hand sanitizer gel preparations that meet the requirements for preparation evaluation.