bluuebunny/crossref_metadata_2025_split huggingface dataset:
A food system transformation can enhance global health, environmental conditions and social inclusion
Authors: Bodirsky Benjamin , Beier Felicitas , Humpenöder Florian , Leip Debbora , Crawford Michael , Chen David , von Jeetze Patrick , Springmann Marco , Soergel Bjoern , Nicholls Zebedee , Strefler Jessica , Lewis Jared , Heinke Jens , Müller Christoph , Karstens Kristine , Weindl Isabelle , Führlich Pascal , Mishra Abhijeet , Bacca Edna Molina , Stevanovic Miodrag , Koberle Alexandre , Wang Xiaoxi , Singh Vartika , Hunecke Claudia , Collignon Quitterie , Schreinemachers Pepijn , Dietz Simon , Kanbur Ravi , Dietrich Jan , Lotze-Campen Hermann , Popp Alexander 
Published: June 2023

Abstract

The current global food system has detrimental outcomes for global health, environmental conditions and social inclusion. A coherent vision of a desirable food system can guide a sustainable food system transformation and help to structure political processes and private decisions by quantifying potential benefits, facilitating debates about co-benefits and trade-offs, and identifying key measures for desirable change. Such a transformation requires integrating measures targeting human diets, livelihoods, biosphere integrity, and agricultural management.
Here, we apply a global food and land system modeling framework to quantify the impacts of 23 food system measures by 2050. Our multi-criteria assessment shows that a food system transformation can improve outcomes for health, the environment, social inclusion, and the economy. All individual measures come with trade-offs, particularly those targeting agricultural management, while few trade-offs and multiple co-benefits are linked to dietary change measures. By combining measures in packages, trade-offs can be reduced and co-benefits enhanced. We show that a sustainable food system also requires a transformation of the overall economy to stop global warming, reduce absolute poverty, and create alternative employment options. Within the context of a cross-sectoral sustainable development pathway, the food system transformation improves 14 of our 15 outcome indicators.
Ultrahigh-Conductive Covalent Organic Framework Films
Authors: Wang Rui , Lyu Hang , Ho Gerald Siu Hang Poon , Chen Huanhuan , Yuan Yufei , Bang Ki-Taek , Kim Yoonseob 
Published: June 2023

Abstract
Chemically inert organic networks exhibiting electrical conductivity comparable to metals can advance organic electronics, catalysis, and energy storage systems. Covalent organic frameworks (COFs) have emerged as promising materials for those applications due to their high crystallinity, porosity, and tunable functionality. However, their low conductivity has limited their practical utilization. In this study, we developed copper-coordinated-fluorinated-phthalocyanine and 2,3,6,7-tetrahydroxy-9,10-anthraquinone-based COF (CuPc-AQ-COF) films with ultrahigh-conductivity. The COF films exhibited an electrical conductivity of 1.53 × 103 S m–1 and a Hall mobility of 6.02 × 102 cm2 V–1 s–1 at 298 K, reaching the level of metals. The films were constructed by linking phthalocyanines and anthraquinones through vapor-assisted synthesis. The high conductivity properties of the films are attributed to the molecular design of the CuPc-AQ-COFs and the generation of high-quality crystals via the vapor-assisted method. Density functional theory analysis revealed that an efficient donor–acceptor system between the copper-coordinated phthalocyanines and anthraquinones significantly promoted charge transfer. Overall, the CuPc-AQ-COF films set new records of COF conductivity and mobility and represent a significant step forward in the development of COFs for electronic, catalytic, and electrochemical applications.
Analyzing the Facial Action Units associated with genuine and fake pain caused by inferior alveolar nerve block in Syrian children: a cross-sectional study
Authors: Alkhouli Muaaz , Al-Nerabieah Zuhair , Dashash Mayssoon 
Published: June 2023

Abstract
This study aimed to investigate the association between facial action units (FAUs) and pain levels in Syrian children, focusing on both genuine and fake pain expressions. A total of 300 Syrian children aged 6-9 years participated in the study. Pain levels were assessed using a validated pain scale (FLACC), and facial expressions were analyzed using the Facial Action Coding System (FACS). The children were asked to mimic their feelings after receiving a dental injection to elicit fake pain expressions. Statistical analysis, including multinomial logistic regression and chi-square tests, was conducted to determine the AUs associated with each pain level and to compare the differences between real and fake pain expressions. The results revealed significant associations between specific AUs and pain levels. For real pain expressions, the most activated AUs across different pain levels with positive coefficient values
of correlation (P-value ＜0.01) were analyzed. In contrast, for fake pain expressions, AU12 and AU38 were consistently observed to be the most activated. These findings suggest that certain AUs are uniquely associated with fake pain expressions, distinct from those observed in real pain expressions. Furthermore, there were no significant differences between boys and girls in terms of their genuine and fake pain expressions, indicating a similar pattern of AU activation (P-value ＞0.05). It was concluded that AUs 4, 6, 41, and 46 were associated with mild pain, and AUs 4, 6, 41, 46, and 11 were associated with moderate pain cases. In severe pain, AUs 4, 6, 7, 9, 11, and 43 were associated. In fake pain feelings, AU43, AU38, and AU12 were the most activated with no difference between boys and girls.
WITHDRAWN: Screening and identification of the potential diagnostic genes for Parkinson's Disease based on Machine Learning algorithm
Authors: Peng Haoran , Chen Siyuan , Wu Shaopu , Shi Xiaoxue , Ma Jianjun , Yang Hongqi , Li Xue 
Published: June 2023

Abstract
Background: Parkinson’s disease (PD) is one of the common neurodegenerative diseases, which have an increasingly morbidity rate, and the genetic markers of PD are receiving increasing attention currently.
Method: From the Gene Expression Omnibus (GEO) database, we downloaded five array datasets which from the brain tissue of patients with PD and healthy people. We screened the differentially expressed genes (DEGs) between PD and healthy control samples while performed intersection analysis with Weighted Gene Coexpression Network Analysis (WGCNA) genes. Then three machine learning algorithms were employed the least absolute shrinkage and selection operator (LASSO) regression, supported vector machine recursive feature elimination (SVM-RFE) and the Random Forest (RF) analyze to selected the hub gene of PD. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of hub gene. Subsequently, the reverse transcription quantitative polymerase chain reaction (RT-qPCR) experimentwas utilized to confirm the expression of hub gene based on the clinic samples. Finally, the correlations between the expression of hub gene and immune cell ratios were investigated using the CIBERSORT algorithm.
Results: Based on the GEO database, 254 overlapping genes were screened from DEG and the blue modules of WGCNA. Functional enrichment analysis showed that these candidate disease genes were associated with PD and might participated in the progression of PD through the MAPK signaling pathway. Two hub genes (EAF2 and HTR1F) were subsequently selected through machine learning algorithms, and the ROC analysis showed that the area under curve (AUC) of both genes were all greater than 0.7 in the experimental datasets and validation datasets. Afterwards, the results of the RT-qPCR experiments demonstrated that the mRNA expression of EAF2 and HTR1F were lower in patients with PD, which consistent with the gene expression results in the GEO dataset. Finally, CIBERSORT analysis indicated the changes of the immune environment in PD patients, and revealed the types of immune cells associated with the expression of EAF2and HTR1F.
Conclusion: Two hub genes of PD, EAF2 and HTR1F, were identified by machine learning algorithms, which might provide a significant target for potential diagnosis and personalized treatment of PD in the future.
Sulfamic Acid Functionalized PVC: A Remarkably Efficient Heterogeneous Reusable Catalyst for the Acid-Catalyzed Reactions
Authors: Wang Zhenzhen , Zhang Rui , Liu Dan , Jiang Dabo , You Tingting , Niu Pan , Chen Quanzhou , He Kejie , Ren Litao , Xu Longjun 
Published: June 2023

Abstract
Sulfamic acid functionalized polyvinyl chloride catalysts (PVC-N-SO3H, N = EDA, DTA, TTA, TPA, PHA) were prepared as efficient heterogeneous solid acid catalysts via two-steps treatment processes. The prepared catalysts were characterized by X-ray diffraction analysis (XRD), TG thermograms/derivative thermogravimetric (TG/DTG), transmission electron microscope (TEM), elemental mappings and energy-dispersive spectroscopy analyses (STEM-EDS), and FT-IR measurements (FT-IR) as well as acid-base back-titration. The acetalization of aldehydes (ketones) and alcohols to acetal (ketal) was selected to evaluate the acid catalytic performance of PVC-N-SO3H. The results showed that PVC-EDA-SO3H exhibit excellent activity and reusability due to its highly exposed sulfonic acid sites, high surface acid density (2.28 mmol g− 1) for the conversion of aldehydes (ketones) to acetal (ketal). This new solid acid has obvious advantages in reusability and catalytic activity over traditional homogeneous concentrated sulfuric acid and heterogeneous sulfonated resin catalysts. Furthermore, PVC-EDA-SO3H exhibited an excellent catalytic performance in the synthesis of 12 acetals (ketals) as well as a good compatibility in the hydroxyalkylation of phenol with formaldehyde to bisphenol F (BPF) and the esterification reaction of oleic acid and methanol to biodiesel. More importantly, it could also be recovered easily and used repeatedly at least nine times without an obvious decrease in the activity.
Status improvement in water and wastewater fixed facilities: Success and challenges of 11 Swedish water utilities as case studies
Authors: Najar Nasik , Persson Kenneth M. 
Published: June 2023

Abstract
Reinvestment in water and wastewater (WW) facilities is a challenge for Swedish water utilities. Nationwide, 4% of 184 organizations meet the requirements for a sustainable WW facility status according to the sustainability index (SI), the Swedish benchmark system. Eleven Swedish municipal WW organizations that had improved the status of their facilities were examined and are presented as good learning examples. Managers/strategists of nine of the organizations were interviewed in depth. Our aims were to concretize the used strategies and to clarify success factors and challenges, as well as to support WW organizations that want to improve their results. The nine surveyed organizations showed a clear desire to move toward sustainability. For example, setting aside 1% of the whole replacement value per year for reinvestment (which is embedded in the policymakers’ business plan) and the use of its own staff for construction work significantly aided the Arvika company's goals. All organizations were found to have a 10-year plan for renewal at the strategic, tactical, and operational levels. Five organizations that had made more significant progress also had more specific 3-year plans and were linked to robust economies. New investments came at the expense of reinvestments because all municipalities are expanding.
Aging and Diabetic Kidney Disease: Emerging Pathogenetic
Mechanisms and Clinical Implications
Authors: Chen Yi , Kanwar Yashpal S. , Chen Xueqin , Zhan Ming 
Published: June 2023

Abstract:
Diabetic kidney disease (DKD) is one of the leading causes of chronic kidney
disease (CKD) and end-stage renal disease (ESRD) worldwide. With the overpowering
trend of aging, the prevalence of DKD in the elderly is progressively increasing. Genetic
factors, abnormal glucose metabolism, inflammation, mitochondrial dysregulation, and
oxidative stress all contribute to the development of DKD. Conceivably, during aging, these
pathobiological processes are likely to be intensified, and this would further exacerbate
the deterioration of renal functions in elderly patients, ultimately leading to ESRD.
Currently, the pathogenesis of DKD in the elderly is not very well-understood. This
study describes an appraisal of the relationship between diabetic nephropathy and aging
while discussing the structural and functional changes in the aged kidney, the impact of
related mechanisms on the outcome of DKD, and the latest advances in targeted therapies.
Network Pharmacology and Molecular Docking to Unveil the Mechanism of
Shudihuang against Amyotrophic Lateral Sclerosis
Authors: Wu Haidong , Wang Tong , Li Xiaojing , Tian Yueqin 
Published: June 2023

Background:
Shudihuang has been clinically proven to be an effective Chinese medicine compatible with the treatment of amyotrophic lateral sclerosis. However, the underlying mechanism of Shudihuang against amyotrophic lateral sclerosis remains unclear.

Objectives:
The present study aims to elucidate the possible mechanism of Shudihuang in treating ALS using network pharmacology and molecular docking.

Methods:
The primary active components of Shudihuang and their relevant targets were identified by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and the Swiss Target Prediction database, respectively. The ALS-related targets were obtained from the Disgenet and OMIM databases. The shared targets were derived by the intersection of disease-associated and component-associated targets and then introduced into the Cytoscape software to construct a network of drug-component-target. In addition, protein interaction relationships among the shared targets were analyzed by the STRING and Cytoscape software. Furthermore, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) functional enrichment analysis were conducted by the Metascape platform. The binding activities between the hub targets and the active components were assessed with molecular docking.

Results:
Dousterol and glutathione were identified as the core components of Shudihuang, and the hub targets of ALS are PTGS2, PPARG, ESR1, IGF-1R, and MAPK3, with the highest degrees in the PPI network. The finding that dousterol and glutathione had a good affinity with PTGS2, PPARG, ESR1, IGF-1R, and MAPK3 also supported this. Finally, it was revealed that Shudihuang treatment of ALS predominantly involves estrogen-related pathways such as nuclear receptor activity and steroid binding.

Conclusion:
In summary, this study suggested that the main active components of Shudihuang (stigmasterol and sitosterol) may exert a critical effect in ALS treatment by binding to hub targets (PTGS2, PPARG, ESR1, IGF-1R, and MAPK3) and then modulating estrogen receptor-related pathways to attenuate glutamate excitotoxicity, inhibit oxidative stress and antagonize inflammation.
The Effect of PEGylation on Drugs’ Pharmacokinetic Parameters; from
Absorption to Excretion
Authors: Khajeei Ali , Masoomzadeh Salar , Gholikhani Tooba , Javadzadeh Yousef 
Published: June 2023

Abstract:
Until the drugs enter humans life, they may face problems in transportation, drug delivery,
and metabolism. These problems can cause reducing drug’s therapeutic effect and even increase its side
effects. Together, these cases can reduce the patient's compliance with the treatment and complicate the
treatment process. Much work has been done to solve or at least reduce these problems. For example,
using different forms of a single drug molecule (like Citalopram and Escitalopram); slight changes in
the drug’s molecule like Meperidine and α-Prodine, and using carriers (like Tigerase®). PEGylation is a
recently presented method that can use for many targets. Poly Ethylene Glycol or PEG is a polymer that
can attach to drugs by using different methods and resulting sustained release, controlled metabolism,
targeted delivery, and other cases. Although they will not necessarily lead to an increase in the effect of
the drug, they will lead to the improvement of the treatment process in certain ways. In this article, the
team of authors has tried to collect and carefully review the best cases based on the PEGylation of drugs
that can help the readers of this article.
Edible Herbal Medicines as an Alternative to Common Medication for
Sleep Disorders: A Review Article
Authors: Hosseini Azar , Mobasheri Leila , Rakhshandeh Hassan , Rahimi Vafa Baradaran , Najafi Zohreh , Askari Vahid Reza 
Published: June 2023

Abstract:
Insomnia is repeated difficulty in falling asleep, maintaining sleep, or experiencing lowquality
sleep, resulting in some form of daytime disturbance. Sleeping disorders cause daytime fatigue,
mental confusion, and over-sensitivity due to insufficient recovery from a sound sleep. There are some
drugs, such as benzodiazepines and anti-histaminic agents, which help to sleep induction and insomnia
cure. However, the prolonged administration is unsuitable because of tolerance and dependence.
Therefore, the researchers attempt to find new medicines with lesser adverse effects. Natural products
have always been good sources for developing new therapeutics for managing diseases such as cancer,
cardiovascular disease, diabetes, insomnia, and liver and renal problems. Ample research has justified
the acceptable reason and relevance of the use of these herbs in the treatment of insomnia. It is worth
noting that in this study, we looked into various Persian herbs in a clinical trial and in vivo to treat insomnia,
such as Artemisia annua, Salvia reuterana, Viola tricolor, Passiflora incarnata, lettuce, and
Capparis spinose. According to research, herb extracts and fractions, particularly n-butanol fractions
with non-polar agents, impact the benzodiazepine receptors and have hypnotic properties. Also, alkaloids,
glycosides, flavonoids, saponins, and tannins in practically every plant are mentioned making
them the popular natural compounds to help with sleep disorders and promote calmness.
Pyrene Appendant Triazole-based Chemosensors for Sensing Applications
Authors: Maddeshiya Tarkeshwar , Jaiswal Manoj K. , Tamrakar Arpna , Mishra Gargi , Awasthi Chhama , Pandey Mrituanjay D. 
Published: June 2023

Abstract:
Over the last two decades, the design and development of fluorescent chemosensors for the targeted detection of Heavy Transition-metal (HTM) ions, anions, and biological ana-lytes, have drawn much interest. Since the introduction of click chemistry in 2001, triazole moie-ties have become an increasingly prominent theme in chemosensors. Triazoles generated via click reactions are crucial for sensing various ions and biological analytes. Recently, the number of studies in the field of pyrene appendant triazole moieties has risen dramatically, with more sophisticated and reliable triazole-containing chemosensors for various analytes of interest de-scribed. This tutorial review provides a general overview of pyrene appendant-triazole-based chemosensors that can detect a variety of metal cations, anions, and neutral analytes by using modular click-derived triazoles.
Association between Self-perceptions of Periodontal Health and Electronic Cigarette use in Young Adults
Authors: Miguras Maite , Leon-Rios Ximena Alejandra 
Published: June 2023

Background:
The present study aimed to determine the association between self-perceptions of periodontal health and electronic cigarette use.

Material and Methods:
The study used an observational, analytical and cross-sectional design. 189 young adults aged 18 to 29 from the Metropolitan area of Lima, Peru, were recruited. In order to evaluate self-reported periodontal health, a questionnaire conceived by Quiroz et al. (2017) was used. This includes 13 questions divided into two dimensions (habits and self-perceived periodontal health). Poisson regression with robust variance was used to examine associations between qualitative variables and calculate raw and adjusted prevalence ratios.

Results:
59.46% of participants using electronic cigarettes were found to have a poor perception of gum health. Statistically significant associations were produced between poor perceptions of gum health and vaping, regarding both raw data (PR=0.81; 95% CI: 0.69-0.95; p=0.011) and data adjusted to consider covariates (PR=0.82; 95% CI: 0.69-0.97; p=0.021). No associations were observed for the dimensions of bleeding during brushing, reddish, and/or swollen gums.

Conclusion:
A relationship was found between poor perceptions of gum health and electronic cigarette use.
Evaluation of Knowledge, Awareness, Preparedness, and Measures among Dental Technicians Attending COVID-19 in Jordan
Authors: Bakri Isra Abdulkarim AL , Khader Yousef , Al Hourani Zeid Ahmad , Alshatrat Sabha Mahmoud 
Published: June 2023

Introduction:During the pandemic of COVID-19, Jordan imposed strict measures and abandoned selected medical procedures. Due to the high risk of cross-infection among dental team members, dental clinics and laboratories were subjected to definite regulations before being allowed back to work.Aims:This survey aims to assess the knowledge, awareness and preparedness of dental technicians in Jordan regarding COVID-19. Also, to investigate prevention measures for dental technicians working during the COVID-19 pandemic.Methods:A cross-sectional self-administered online survey was distributed electronically as a Google formviasocial media platforms. The study population consisted of registered dental technicians working in public and private laboratories in Jordan. The questionnaire consisted of a series of questions; demographic characteristics; knowledge and awareness about COVID-19, and the preparedness and measures to practice dental laboratory procedures during the pandemic.Results:This study included a total of 90 dental technicians (31 females and 59 males); their ages ranged from 22-60 years old. Almost all the participants (90%) were found knowledgeable about COVID-19. Governmental organizations, and visual and social media were the main sources of information. The majority of participants (>85%) encouraged drifting to digital dental technology protocols during COVID-19 pandemic. More than 65% of the participants reported COVID-19 very dangerous and considered themselves in a high risk of COVID-19 transmission.Conclusion:Most dental technicians have sufficient knowledge about COVID-19. However, most of them are not prepared to deal with impressions, restorations, and dentures of infected/suspected cases. Educational and training programs regarding COVID-19 among dental technicians are significantly needed.