bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protocol for a prospective, longitudinal study of cognitive impairment in young patients with cancer: a multidisciplinary neuroscience approach (MyBrain)
Authors: Nordhjem Barbara Johanne Thomas , Tjørnlund Morten , Thomsen Birthe Lykke , Hjerming Maiken , Kjær Troels Wesenberg , Pappot Helle , Hjalgrim Lisa Lyngsie 
Published: May 2023

IntroductionThe aim of this research is to investigate young cancer patients’ cognitive functioning and the underlying neurobiological mechanisms when cognitive functions are impaired. The MyBrain protocol is a multidisciplinary study that investigates cancer-related cognitive impairment in children, adolescents and young adults, combining neuropsychology, cognitive neuroscience and cellular neuroscience. The study is exploratory with a wide focus on trajectories of cognitive functions from diagnosis to the end of treatment and into survivorship.Methods and analysisProspective longitudinal study including patients diagnosed with non-brain cancers at age 7–29 years. Each patient is paired with a control matched on age and social circle.Primary objectiveEvaluation of neurocognitive function over time.Secondary objectivesEvaluation of self-perceived quality of life and fatigue, P300 in an electroencephalography (EEG) oddball paradigm, power spectrum in resting state EEG, serum and cerebrospinal fluid levels of biomarkers of neuronal damage, neuroplasticity, proinflammatory and anti-inflammatory markers and their association with cognitive function.Ethics and disseminationThe study is approved by the Regional Ethics Committee for the Capital Region of Denmark (no. H-21028495), and the Danish Data Protection Agency (no. P-2021-473). Results are expected to guide future interventions to prevent brain damage and support patients with cognitive difficulties.Trial registration numberThe article is registered at clinicaltrials.govNCT05840575(https://clinicaltrials.gov/ct2/show/NCT05840575)
Vaccine Preventable Disease Seroprevalence in a Nationwide Assessment of Timor-Leste (VASINA-TL): study protocol for a population-representative cross-sectional serosurvey
Authors: Arkell Paul , Sheridan Sarah L , Martins Nelson , Tanesi Maria Y , Gomes Nelia , Amaral Salvador , Oakley Tessa , Solano Vanessa , David Michael , Draper Anthony D K , Sarmento Nevio , da Silva Endang , Alves Lucsendar , Freitas Carlito , Machado Filipe de Neri , Gusmão Celia , da Costa Barreto Ismael , Fancourt Nicholas S S , Macartney Kristine , Yan Jennifer , Francis Joshua R 
Published: May 2023

IntroductionHistoric disruption in health infrastructure combined with data from a recent vaccine coverage survey suggests there are likely significant immunity gaps to vaccine preventable diseases and high risk of outbreaks in Timor-Leste. Community-based serological surveillance is an important tool to augment understanding of population-level immunity achieved through vaccine coverage and/or derived from prior infection.Methods and analysisThis national population-representative serosurvey will take a three-stage cluster sample and aims to include 5600 individuals above 1 year of age. Serum samples will be collected by phlebotomy and analysed for measles IgG, rubella IgG, SARS-CoV-2 antispike protein IgG, hepatitis B surface antibody and hepatitis B core antigen using commercially available chemiluminescent immunoassays or ELISA. In addition to crude prevalence estimates and to account for differences in Timor-Leste’s age structure, stratified age-standardised prevalence estimates will be calculated, using Asia in 2013 as the standard population. Additionally, this survey will derive a national asset of serum and dried blood spot samples which can be used for further investigation of infectious disease seroepidemiology and/or validation of existing and novel serological assays for infectious diseases.Ethics and disseminationEthical approval has been obtained from the Research Ethics and Technical Committee of the Instituto Nacional da Saúde, Timor-Leste and the Human Research Ethics Committee of the Northern Territory Department of Health and Menzies School of Health Research, Australia. Co-designing this study with Timor-Leste’s Ministry-of-Health and other relevant partner organisations will allow immediate translation of findings into public health policy, which may include changes to routine immunisation service delivery and/or plans for supplementary immunisation activities.
Self-medication with over-the-counter drugs among consumers: a cross-sectional survey in a Southwestern State in Nigeria
Authors: Akande-Sholabi Wuraola , Akinyemi Olamide Olubodunde 
Published: May 2023

ObjectivesThis study set out to assess the knowledge, perception and practices of consumers regarding self-medication with over-the-counter (OTC) drugs, the prevalence of risky practices and their associated factors in pharmacy outlets in Ibadan, Southwestern Nigeria.SettingA cross-sectional study was conducted using an interviewer administered questionnaire. Descriptive statistics and multivariate analysis were performed by using SPSS V.23 with statistical significance set at p<0.05.Participants658 adult consumers aged 18 years and above.Primary and secondary outcome measuresThe primary outcome was self-medication, measured using the following question: A positive answer indicates a self-medicated participant. Do you practise self-medication?ResultsRespondents who had practised self-medication with OTC drugs were 562 (85.4%), of which over 95% were involved in risky practice. Consumers agreed (73.4%) that OTC drugs can be recommended by pharmacists and perceived (60.4%) that OTC drugs are harmless regardless of how they are used. Reasons for practising self-medication with OTC drugs include: if it is a minor condition, I can take the initiative (90.9%), visiting a hospital wastes my time (75.5%) and ease accessibility of the pharmacy (88.9%). Overall, (83.7%) respondents had good practices of handling and use of OTC drugs, while (56.1%) had good knowledge of OTC drugs and identification of OTC drugs. Factors associated with consumer handling and use of OTC drugs in self-medication were older participants (p=0.01), those with postsecondary education (p=0.02), and who possessed good knowledge (0.02), were more likely to practise self-medication with OTC drugs.ConclusionThe study revealed a high prevalence of self-medication, good practices towards handling and use of OTC drugs, and moderate knowledge of OTC drugs by the consumers. This underscores the need for policy-makers to introduce measures to enforce consumer education by community pharmacists to minimise the risks of inappropriate self-medication with OTC drugs.
B lymphocytes in treatment-naive paediatric patients with lupus are epigenetically distinct from healthy children
Authors: Hui-Yuen Joyce , Jiang Kaiyu , Malkiel Susan , Eberhard Barbara Anne , Walters Heather , Diamond Betty , Jarvis James 
Published: May 2023

BackgroundSLE is likely triggered by gene–environment interactions. We have shown that most SLE-associated haplotypes encompass genomic regions enriched for epigenetic marks associated with enhancer function in lymphocytes, suggesting genetic risk is exerted through altered gene regulation. Data remain scarce on how epigenetic variance contributes to disease risk in paediatric SLE (pSLE). We aim to identify differences in epigenetically regulated chromatin architecture in treatment-naive patients with pSLE compared with healthy children.MethodsUsing the assay for transposase-accessible chromatin with sequencing (ATACseq), we surveyed open chromatin in 10 treatment-naive patients with pSLE, with at least moderate disease severity, and 5 healthy children. We investigated whether regions of open chromatin unique to patients with pSLE demonstrate enrichment for specific transcriptional regulators, using standard computational approaches to identify unique peaks and a false discovery rate of <0.05. Further analyses for histone modification enrichment and variant calling were performed using bioinformatics packages in R and Linux.ResultsWe identified 30 139 differentially accessible regions (DAR) unique to pSLE B cells; 64.3% are more accessible in pSLE than healthy children. Many DAR are found in distal, intergenic regions and enriched for enhancer histone marks (p=0.027). B cells from adult patients with SLE contain more regions of inaccessible chromatin than those in pSLE. In pSLE B cells, 65.2% of the DAR are located within or near known SLE haplotypes. Further analysis revealed enrichment of transcription factor binding motifs within these DAR that may regulate genes involved in pro-inflammatory responses and cellular adhesion.ConclusionsWe demonstrate an epigenetically distinct profile in pSLE B cells when compared with healthy children and adults with lupus, indicating that pSLE B cells are predisposed for disease onset/development. Increased chromatin accessibility in non-coding genomic regions controlling activation of inflammation suggest that transcriptional dysregulation by regulatory elements controlling B cell activation plays an important role in pSLE pathogenesis.
Identifying latent activity behaviors and lifestyles using mobility data to describe urban dynamics
Authors: Yang Yanni , Pentland Alex , Moro Esteban 
Published: May 2023

AbstractUrbanization and its problems require an in-depth and comprehensive understanding of urban dynamics, especially the complex and diversified lifestyles in modern cities. Digitally acquired data can accurately capture complex human activity, but it lacks the interpretability of demographic data. In this paper, we study a privacy-enhanced dataset of the mobility visitation patterns of 1.2 million people to 1.1 million places in 11 metro areas in the U.S. to detect the latent mobility behaviors and lifestyles in the largest American cities. Despite the considerable complexity of mobility visitations, we found that lifestyles can be automatically decomposed into only 12 latent interpretable activity behaviors on how people combine shopping, eating, working, or using their free time. Rather than describing individuals with a single lifestyle, we find that city dwellers’ behavior is a mixture of those behaviors. Those detected latent activity behaviors are equally present across cities and cannot be fully explained by main demographic features. Finally, we find those latent behaviors are associated with dynamics like experienced income segregation, transportation, or healthy behaviors in cities, even after controlling for demographic features. Our results signal the importance of complementing traditional census data with activity behaviors to understand urban dynamics.
Aphelenchoides koreanus n. sp. (Tylenchina: Aphelenchoididae) found in packaging wood from South Korea
Authors: Gu Jianfeng , Fang Yiwu , Ma Xinxin 
Published: May 2023

Summary
Aphelenchoides koreanus n. sp. isolated in Ningbo Port, P.R. China, from Pinus packaging wood from South Korea is described. It is characterised by the female length of 603 (511-687) μm, stout body shape (a = 24.4 (21.9-26.7)). The lateral field has four incisures. The slender stylet is 12.3 (11.7-13.4) μm long and has small basal swellings. The excretory pore is located posterior to the nerve ring. The hemizonid is immediately posterior to excretory pore, but sometimes invisible. The vagina is not sclerotised, and the vulva has strongly protruding lips and lacks a flap. The PUS is well developed and forms ca 30.6-41.9% of the vulva to anus distance. Tail sub-cylindrical, terminus bluntly rounded or slightly pointed, always bearing a very short mucron or a small projection, about 1 μm long. Males absent. The new species belongs to the group 1 category of Aphelenchoides species sensu Shahina. Phylogenetic analysis based on ITS sequences confirmed its status as a new species.
Large-Scale Anomalous Cyclone in the Western North Pacific
Authors: Wang Haili , Wang Chunzai 
Published: May 2023

Abstract
The large-scale anomalous anticyclone in the western North Pacific (WNP) has been extensively studied, but the large-scale anomalous cyclone has not received much attention in the past years. In this study, we use observational data to find that the occurrence numbers of the anomalous cyclone and anticyclone in the WNP have been roughly the same from 1979 to 2020. Our analyses indicate that the WNP anomalous cyclone is an interannual circulation anomaly in the WNP, which can persist from boreal autumn to the subsequent spring during a La Niña year and from spring to summer during a developing El Niño year. To confirm the roles of the central equatorial Pacific, tropical Indian Ocean, and central WNP sea surface temperatures, we perform a suite of model experiments using an atmospheric general circulation model. The model experiments demonstrate that central equatorial Pacific warming contributes to the WNP anomalous cyclone during a developing El Niño year. Cooling in the central equatorial Pacific or the tropical Indian Ocean alone cannot induce the WNP anomalous cyclone, but the combination of central equatorial Pacific cooling, tropical Indian Ocean cooling, and central WNP warming can jointly induce the WNP anomalous cyclone during a La Niña year. Similar to the WNP anomalous anticyclone, the WNP anomalous cyclone and its climatic impacts deserve attention.
Temporal and Spatial Amplification of Extreme Rainfall and Extreme Floods in a Warmer Climate
Authors: Faghih Mina , Brissette François 
Published: May 2023

Abstract
This work explores the relationship between catchment size, rainfall duration, and future streamflow increases on 133 North American catchments with sizes ranging from 66.5 to 9886 km2. It uses the outputs from a high spatial (0.11°) and temporal (1-h) resolution single model initial-condition large ensemble (SMILE) and a hydrological model to compute extreme rainfall and streamflow for durations ranging from 1 to 72 h and for return periods of between 2 and 300 years. Increases in extreme precipitation are observed across all durations and return periods. The projected increases are strongly related to duration, frequency, and catchment size, with the shortest durations, longest return periods, and smaller catchments witnessing the largest relative rainfall increases. These increases can be quite significant, with the 100-yr rainfall becoming up to 20 times more frequent over the smaller catchments. A similar duration–frequency–size pattern of increases is also observed for future extreme streamflow, but with even larger relative increases. These results imply that future increases in extreme rainfall will disproportionately impact smaller catchments, and particularly so for impervious urban catchments which are typically small, and whose stormwater drainage infrastructures are designed for long-return-period flows, both being conditions for which the amplification of future flow will be maximized.
Advanced Tropical Cyclone Prediction Using the Experimental Global ECMWF and Operational Regional COAMPS-TC Systems
Authors: Majumdar Sharanya J. , Magnusson Linus , Bechtold Peter , Bidlot Jean Raymond , Doyle James D. 
Published: May 2023

Abstract
Structure and intensity forecasts of 19 tropical cyclones (TCs) during the 2020 Atlantic hurricane season are investigated using two NWP systems. An experimental 4-km global ECMWF model (EC4) with upgraded moist physics is compared with a 9-km version (EC9) to evaluate the influence of resolution. EC4 is then benchmarked against the 4-km regional COAMPS–Tropical Cyclones (COAMPS-TC) system (CO4) to compare systems with similar resolutions. EC4 produced stronger TCs than EC9, with a >30% reduction of the maximum wind speed bias in EC4, resulting in lower forecast errors. However, both ECMWF predictions struggled to intensify initially weak TCs, and the radius of maximum winds (RMW) was often too large. In contrast, CO4 had lower biases in central pressure, maximum wind speed, and RMW. Regardless, minimal statistical differences between CO4 and EC4 intensity errors were found for ≥36-h forecasts. Rapid intensification cases yielded especially large intensity errors. CO4 produced superior forecasts of RMW, together with an excellent pressure–wind relationship. Differences in the results are due to contrasting physics and initialization schemes. ECMWF uses global data assimilation with no special treatment of TCs, whereas COAMPS-TC constructs a vortex for TCs with initial intensity ≥55 kt (∼28 m s−1) based on data provided by forecasters. Two additional ECMWF experiments were conducted. The first yielded improvements when the drag coefficient was reduced at high wind speeds, thereby weakening the coupling between the low-level winds and the surface. The second produced overly intense TCs when explicit deep convection was used, due to unrealistic mid–upper-tropospheric heating.

Significance Statement
Improved forecasts of tropical storms and hurricanes depend on advances in computer weather models. We tested an experimental high-resolution (4 km) version of the global ECMWF model against its 9-km counterpart to evaluate the influence of resolution on storm position and intensity. We also compared this with the 4-km U.S. Navy model, which is designed for tropical storms and hurricanes. Over a 3-month period during the active 2020 Atlantic hurricane season, we found that increasing the horizontal resolution improved intensity forecasts. The Navy model forecasts were superior for the radius of maximum winds and had lower intensity biases. Two additional experiments with the ECMWF model revealed the importance of simulating air–sea interaction in high winds and current challenges with explicitly simulating deep thunderstorm clouds in their system.
An Objective Method for Clustering Observed Vertical Thermodynamic Profiles by Their Boundary Layer Structure
Authors: Blount Dillon V. , Evans Clark , Jirak Israel L. , Dean Andrew R. , Kravtsov Sergey 
Published: May 2023

Abstract
This study introduces a novel method for comparing vertical thermodynamic profiles, focusing on the atmospheric boundary layer, across a wide range of meteorological conditions. This method is developed using observed temperature and dewpoint temperature data from 31 153 soundings taken at 0000 UTC and 32 308 soundings taken at 1200 UTC between May 2019 and March 2020. Temperature and dewpoint temperature vertical profiles are first interpolated onto a height above ground level (AGL) coordinate, after which the temperature of the dry adiabat defined by the surface-based parcel’s temperature is subtracted from each quantity at all altitudes. This allows for common sounding features, such as turbulent mixed layers and inversions, to be similarly depicted regardless of temperature and dewpoint temperature differences resulting from altitude, latitude, or seasonality. The soundings that result from applying this method to the observed sounding collection described above are then clustered to identify distinct boundary layer structures in the data. Specifically, separately at 0000 and 1200 UTC, a k-means clustering analysis is conducted in the phase space of the leading two empirical orthogonal functions of the sounding data. As compared to clustering based on the original vertical profiles, which results in clusters that are dominated by seasonal and latitudinal differences, clusters derived from transformed data are less latitudinally and seasonally stratified and better represent boundary layer features such as turbulent mixed layers and pseudoadiabatic profiles. The sounding-comparison method thus provides an objective means of categorizing vertical thermodynamic profiles with wide-ranging applications, as demonstrated by using the method to verify short-range Global Forecast System model forecasts.
A Nowcasting Approach for Low-Earth-Orbiting Hyperspectral Infrared Soundings within the Convective Environment
Authors: Kahn Brian H. , Berndt Emily B. , Case Jonathan L. , Kalmus Peter M. , Richardson Mark T. 
Published: May 2023

Abstract
Low-Earth-orbiting (LEO) hyperspectral infrared (IR) sounders have significant yet untapped potential for characterizing thermodynamic environments of convective initiation and ongoing convection. While LEO soundings are of value to weather forecasters, the temporal resolution needed to resolve the rapidly evolving thermodynamics of the convective environment is limited. We have developed a novel nowcasting methodology to extend snapshots of LEO soundings forward in time up to 6 h to create a product available within National Weather Service systems for user assessment. Our methodology is based on parcel forward-trajectory calculations from the satellite-observing time to generate future soundings of temperature (T) and specific humidity (q) at regularly gridded intervals in space and time. The soundings are based on NOAA-Unique Combined Atmospheric Processing System (NUCAPS) retrievals from the Suomi National Polar-Orbiting Partnership (Suomi NPP) and NOAA-20 satellite platforms. The tendencies of derived convective available potential energy (CAPE) and convective inhibition (CIN) are evaluated against gridded, hourly accumulated rainfall obtained from the Multi-Radar Multi-Sensor (MRMS) observations for 24 hand-selected cases over the contiguous United States. Areas with forecast increases in CAPE (reduced CIN) are shown to be associated with areas of precipitation. The increases in CAPE and decreases in CIN are largest for areas that have the heaviest precipitation and are statistically significant compared to areas without precipitation. These results imply that adiabatic parcel advection of LEO satellite sounding snapshots forward in time are capable of identifying convective initiation over an expanded temporal scale compared to soundings used only during the LEO satellite overpass time.

Significance Statement
Advection of low-Earth-orbiting (LEO) satellite observations of temperature and specific humidity forward in time exhibits skill in determining where and when convection eventually initiates. This approach provides a foundation for a new nowcasting methodology leveraging thermodynamic soundings derived from hyperspectral infrared (IR) sounders on LEO satellite platforms. This method may be useful for creating time-resolved soundings with the constellation of LEO satellites until hyperspectral infrared soundings are widely available from geostationary platforms.