bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acid‐Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function
Authors: Liao Xu , Tang Min , Li Jiejing , Guo Runze , Zhong Chongbin , Chen Xiangzhou , Zhang Xuwei , Mo Hongwei , Que Dongdong , Yu Wenjie , Song Xudong , Li Hekai , Cai Yanbin , Yang Pingzhen 
Published: January 2025

AbstractRedox imbalance, including excessive production of reactive oxygen species (ROS) caused by mitochondrial dysfunction and insufficient endogenous antioxidant capacity, is the primary cause of myocardial ischemia‒reperfusion (I/R) injury. In the exploration of reducing myocardial I/R injury, it is found that protecting myocardial mitochondrial function after reperfusion not only reduces ROS bursts but also inhibits cell apoptosis triggered by the release of cytochrome c. Additionally, nuclear factor erythroid 2‐related factor 2 (Nrf2) is considered a potential therapeutic target for treating myocardial I/R injury by enhancing the cellular antioxidant capacity through the induction of endogenous antioxidant enzymes. In this study, a peptide‒drug conjugate OI‐FFG‐ss‐SS31(ISP) is developed by integrating the Nrf2 activator 4‐octyl itaconate (OI) and the mitochondria‐targeting protective peptide elamipretide (SS31), and its therapeutic potential for myocardial I/R injury is explored. The results showed that ISP could self‐assemble into nanofibers in response to the acidic microenvironment and bind to Keap‐1 with high affinity, thereby activating Nrf2 and enhancing antioxidant capacity. Simultaneously, the release of SS31 could improve mitochondrial function and reduce ROS, ultimately providing a restoration of redox homeostasis to effectively alleviate myocardial I/R injury. This study presents a promising acid‐triggered peptide‐drug conjugate for treating myocardial I/R injury.
Resonantly Enhanced Hybrid Wannier–Mott–Frenkel Excitons in Organic–Inorganic Van Der Waals Heterostructures
Authors: Fu Shaohua , Ding Jianwei , Lv Haifeng , Zheng Yue , Liu Shuangyan , Zhao Kun , Bai Zhiying , Shi Yumeng , He Dawei , Wang Rui , Zhao Jimin , Wu Xiaojun , Tang Dongsheng , Qiu Xiaohui , Wang Yongsheng , Zhang Xiaoxian 
Published: January 2025

AbstractHybrid excitons formed via resonant hybridization in 2D material heterostructures feature both large optical and electrical dipoles, providing a promising platform for many‐body exciton physics and correlated electronic states. However, hybrid excitons at organic–inorganic interface combining the advantages of both Wannier–Mott and Frenkel excitons remain elusive. Here, hybrid excitons are reported in the copper phthalocyanine/molybdenum diselenide (CuPc/MoSe2) heterostructure (HS) featuring strong molecular orientation dependence by low‐temperature photoluminescence and absorption spectroscopy. The hybrid Wannier–Mott–Frenkel excitons exhibit a large oscillator strength and display signatures of the Frenkel excitons in CuPc and the Wannier–Mott excitons in MoSe2 simultaneously through the delocalized electrons. The density functional theory (DFT) calculations further confirm the strong hybridization between the lowest unoccupied molecular orbital (LUMO) of CuPc and the conduction band minimum (CBM) of MoSe2. The out‐of‐plane molecular orientation is further employed to tune the hybridization strength and tailor the hybrid exciton states. The results reveal the hybrid excitons at the CuPc/MoSe2 interface with tunability by molecular orientation, suggesting that the organic–inorganic HS constitutes a promising platform for many‐body exciton physics such as exciton condensation and optoelectrical applications.
Metalloparticle‐Engineered Pickering Emulsion Displaying AAV‐Vectored Vaccine for Enhancing Antigen Expression and Immunogenicity Against Pathogens
Authors: Guo Zhaofei , Wu Fuhua , Guo Chenqi , Hu Rui , Ou Yangsen , Zhu Yining , Luo Shuang , Song Yuanshuai , He Penghui , He Chunting , Xu Yanhua , Tang Xue , Qin Ming , Wang Hairui , Du Guangsheng , Sun Xun 
Published: January 2025

AbstractRecombinant adeno‐associated viruses (rAAVs) have emerged as promising vaccine vectors due to their enduring efficacy with a single dose. However, insufficient cellular immune responses and the random and non‐specific distribution of AAVs post‐injection may hinder the development of AAV vaccines. Here, a novel Pickering emulsion platform stabilized by biomineralized manganese nanoparticles and aluminum hydroxide, which can rapidly and efficiently load AAVs, is reported. This platform confers AAVs with favorable in vivo distribution kinetics, diversifying AAV endocytic pathways with reduced dependency on the sialic acid receptor‐mediated route, and ultimately enhancing AAV infection efficiency in antigen present cells (APCs). Concurrently, the Pickering emulsion substantially boosts endogenous 2′3′‐cGAMP production, further activating the cGAS‐STING pathway for stronger immune responses and improving protective efficacy in bacterial infection models. The STING pathway activation also increases AAV target gene expression, potently augmenting the cross‐protective potential of AAV vaccines for COVID‐19. These synergistic effects ensure that effective immune responses are induced even at one‐fifth of the AAV vaccination dose, while the Pickering emulsion further reduces the accumulation of AAV in the liver, thereby improving their safety. The findings highlight the potential of Pickering emulsions as valuable enhancers for viral vectors, providing insights for their broader clinical applicability.
Matrix‐Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility
Authors: Shin Seung Jae , Bayarkhangai Buuvee , Tsogtbaatar Khaliunsarnai , Yuxuan Meng , Kim Sang‐Hyun , Kim Yong‐Jae , Taghizadeh Ali , Kim Daesan , Kim Dong‐Hwee , Lee Jung‐Hwan , Hyun Jeongeun , Kim Hae‐Won 
Published: January 2025

AbstractMacrophages encounter a myriad of biochemical and mechanical stimuli across various tissues and pathological contexts. Notably, matrix rigidity has emerged as a pivotal regulator of macrophage activation through mechanotransduction. However, the precise mechanisms underlying the interplay between mechanical and biochemical cues within the nuclear milieu remain elusive. Here We elucidate how the increased matrix rigidity drives macrophages to amplify alternatively‐activated (M2 phenotype) signaling cooperatively with biochemical cues (e.g., IL4/13) through altered nuclear mechanics. We demonstrate that reconstructed podosome‐like F‐actins and contractility induce nucleus deformation, opening nuclear pores, which facilitates nuclear translocation of the key transcription factor STAT6. Furthermore, the altered nuclear mechanics increases chromatin accessibility induced by H3K9 methylation, particularly of M2‐associated gene promoters. These cooperative events of the mechano‐chemical signaling at the cytoskeletal‐to‐nuclear domains facilitate M2 transcriptional activation and cellular functions. We further evidence the rigidity‐primed M2 macrophages are immunosuppressive and accumulated within stiffened tumors in patients. This study proposes a mechanism by which matrix mechanics crosstalks with biochemical signals to potentiate macrophage activation through nuclear mechanosensing and chromatin modifications, offering insights into macrophage mechanobiology and its therapeutic modulations.
Adult‐Onset Hypomagnesemia With Secondary Hypocalcemia Caused by a Novel Variant in TRPM6 Gene: A Case Report
Authors: Chen Yan , Liang Jian , Hu Yuhua , Hong Yunyun , Liu Qiang 
Published: January 2025

ABSTRACTHereditary hypomagnesemia with secondary hypocalcemia (HSH) is a rare autosomal recessive disorder caused by biallelic variants in the transient receptor potential melastatin 6 (TRPM6) gene, typically presenting in infancy. Currently, there is a lack of reports in the literature on adult‐onset cases. This case report describes a 51‐year‐old male with adult‐onset HSH, presenting with limb weakness, muscle spasms, and electrolyte imbalances, including severe hypomagnesemia (0.28 mmol/L). Genetic testing revealed a novel heterozygous variant in the TRPM6 gene (c.4914del, p.E1638Dfs*8), classified as likely pathogenic. The patient's symptoms significantly improved following magnesium supplementation, and his electrolyte levels gradually normalized. This case highlights the importance of considering HSH in patients with unexplained hypomagnesemia and emphasizes the role of genetic testing in confirming the diagnosis. The findings also suggest that magnesium supplementation can effectively alleviate symptoms and improve the quality of life in patients with adult‐onset HSH. Early recognition and treatment are crucial to prevent potential complications, such as neurological damage.
How do principals’ paternalistic leadership impact teachers’ emotional labor and efficacy: Do gender or region of teachers make a difference?
Authors: Huang Shenghua , Zhang Yanan , Yin Hongbiao 
Published: January 2025

AbstractUsing multigroup structural equation modelling, this study investigated the relationships between paternalistic leadership, emotional labour and teacher efficacy, as well as the moderating roles of gender and region among a group of Chinese primary school teachers. The overall results revealed that both authoritarianism and benevolence dimensions of paternalistic leadership have positive impacts on teachers’ emotional labour, albeit with different strengths. Stronger connections were found between authoritarianism and surface acting, and between benevolence and deep acting/the expression of naturally felt emotions. Surface acting was found to have more negative effects, while deep acting and the expression of naturally felt emotions were more positively associated with teacher efficacy. The results of multigroup structural equation modelling supported the invariant measurement models across gender and region, revealing notable differences subgroups. Theoretical contributions and practical implications are also discussed.
Exploring the Anti‐Adherence Potential of Skt35 to Combat Catheter‐Associated Staphylococcus aureus Infections: Efficacy, Toxicity and Mechanism of Action
Authors: Meenatchi Ramu , Priya Snega , Shreya Chakraborty , Gopi Sanjay , Rajagopal Rajakrishnan , Kaliraj S. , Kumaradoss Kathiravan Muthu , Arockiaraj Jesu 
Published: January 2025

ABSTRACTCatheter‐associated urinary tract infections (CAUTIs), often caused by biofilm‐forming Staphylococcus aureus, present significant clinical challenges. Skt35, a dioxopiperidinamide derivative of cinnamic acid, was investigated for its potential antibacterial and antibiofilm activities against S. aureus biofilms. The antibacterial effect of Skt35 was assessed using the zone of inhibition and microdilution methods, revealing a minimum inhibitory concentration (MIC) of 250 µM. Antibiofilm properties were confirmed through crystal violet assays, scanning electron microscopy and confocal laser scanning microscopy, showing significant biofilm inhibition at the Sub‐MIC. In an in vitro bladder model, Skt35‐coated silicone catheter tubes exhibited significant antiadhesive effects. Zebrafish embryo tests indicated no toxicity at concentrations up to 125 µM. Molecular docking and simulation analysis revealed strong binding affinities of Skt35 to Accessory Gene Regulator A (‐7.9 kcal/mol) and Lux Small protein (‐4.96 kcal/mol), suggesting potential disruption of quorum sensing and gene expression in S. aureus, making it a promising candidate for catheter coatings to prevent CAUTIs.
Long‐Term Bioprosthetic Valve Durability After Transcatheter Aortic Valve Replacement With Supra‐Annular Self‐Expanding Versus Intra‐Annular Balloon‐Expandable Valves in Patients With a Small Aortic Annulus
Authors: Matsuhiro Yutaka , Mizote Isamu , Nakamura Daisuke , Dohi Tomoharu , Maeda Koichi , Shimamura Kazuo , Kawamura Ai , Yamashita Kizuku , Kosugi Shumpei , Okuno Shota , Sugae Hiroki , Takeda Yasuharu , Sakata Yasushi 
Published: January 2025

ABSTRACTBackgroundThe long‐term valve durability of supra‐annular self‐expanding valves (SEV) and intra‐annular balloon‐expandable valves (BEV) in patients with small aortic annuli remains unexplored.AimsThis study aimed to determine the long‐term bioprosthetic valve durability with SEV versus BEV in patients with small aortic annuli.MethodsThis retrospective study included patients with severe aortic stenosis (AS) and an aortic annulus area of 430 mm2 or less who underwent transcatheter aortic valve replacement using SEV and BEV between October 2009 and December 2022. Based on the Valve Academic Research Consortium's three definitions, the endpoints were hemodynamic structural valve deterioration (SVD) and bioprosthetic valve failure (BVF). Inverse probability of treatment weighting (IPTW) was used to compare between the two groups and adjust for baseline characteristics. The Fine‐Gray subdistribution hazard model accounted for the competing risk of death.ResultsIn total, 565 patients (204 treated with SEV and 361 treated with BEV) were included. The median follow‐up duration was 3.6 years [2.0 years, 5.7 years], and the maximum was 12.3 years. Hemodynamic SVD and BVF were less frequently identified in the SEV group than in the BEV group (1.1% vs. 9.1% within 5 years, 0.7% vs. 8.1% within 5 years, respectively). On the IPTW adjusted Fine‐Gray subdistribution hazard model analysis, hemodynamic SVD was less frequent in SEV compared with BEV (Hazard Ratio [HR]: 0.16; 95% Confidence Interval [CI]: 0.04–0.56, p = 0.004). SEV was also associated with a lower BVF risk than BEV (HR: 0.25; 95% CI: 0.08–0.76, p = 0.015).ConclusionsSEV appears to be more suitable for long‐term valve durability in patients with a small aortic annulus.
Effect of structure parameters on solid particle erosion resistance coupled biomimetic anti‐erosion functional surface: A CFD‐DPM investigation
Authors: Dong Yunshan , Guo Jialiang , Yang Kun , Si Xiaodong , Pan Hongyu 
Published: January 2025

AbstractIn this study, the effect of structure parameters on solid particle erosion resistance coupled biomimetic surface was investigated, revealing the optimal structural parameters that minimized erosion. A calculation process of erosion characteristics using computational fluid dynamics (CFD) was developed to simulate the erosion physical process. Results indicated that as the bump diameter and the groove width increased, the erosion rate of the biomimetic surface decreased for a given particle size, but the influence of groove width was greater than that of bump diameter. For a given particle size, as the groove width‐to‐depth ratio increased, the erosion rate of the biomimetic surface decreased initially and then increased, with an optimal value between 2.5 and 3 that yielded the lowest erosion. Additionally, changes in particle collision velocity were primarily governed by the vortex scale and intensity within the groove, while changes in particle collision angle were mainly influenced by the groove scale and angle.
Selecting the Optimal DFT Functionals for Reproducing the UV‐Vis Properties of Transition‐Metal Photocatalysts
Authors: Fehér Péter Pál , Stirling András 
Published: January 2025

AbstractWe have applied our practice‐oriented TDDFT benchmark strategy to assess the performance of pure, hybrid, range‐separated hybrid and double‐hybrid functionals for reproducing the electronic spectra of a set of 137 transition‐metal complexes. Our results enable simple pre‐screening of new transition‐metal based photocatalysts. The reference data is based on recently published measurements, from which we have established a new database. The database is named TMPHOTCAT‐137 to reflect the number of complexes (with Cu, Ru, Ir, Fe, Au, Mo and W centres) included and the fact that all of them are either proven or potential photocatalysts. We have found that the M06 functional is the best performer both in terms of practical accuracy and consistency for all metals except Fe. While B3LYP is similarly accurate for Ru and Ir complexes, for the rest of the metals significant wavelength scaling is necessary. Compared to our previous benchmark for organic photocatalysts, double‐hybrid functionals exhibit considerably poorer results while the range separated hybrids CAM−B3LYP and ωB97X−D offer the most consistent performance for both datasets. Among the metals, iron proved to be most difficult for TDDFT: even M06 predicts singlet‐singlet absorption spectra and quintet ground states erroneously, especially for weak ligand fields (i. e., only Fe−N bonds). The functionals that do not exhibit this behaviour are the pure (GGA, meta‐GGA) functionals, but the role of HF exchange in the spectral prediction is equivocal; while functionals with high amounts of HF exchange perform insufficiently, smaller amount of exact exchange yields overall better performance (M06, B3LYP). We have also shown that inclusion of spin‐orbit coupling for the heavier metals does not improve the results. The updated spectrum optimizer code, the TMPHOTCAT‐137 database and the Jupyter Notebook used for analysis are available at github.com/PeterF1234/spectrum_optimizer.
Bioequivalence Study of Bedaquiline Fumarate Tablets in Healthy Chinese Subjects
Authors: Yang Man , Pei Yingzi , Chen Chen , Xi Jian , Xia Yue , Zhang Shuyu , Liu Huichen , Li Aimin 
Published: January 2025

AbstractBedaquiline fumarate tablets are a novel oral antimycobacterial drug. This study assessed the bioequivalence of a generic bedaquiline fumarate tablet compared to a reference tablet under fasting (n = 44) and fed (n = 24) conditions. Conducted as a single‐center, randomized, open‐label, 2‐sequence, crossover trial, 68 participants were randomly assigned to receive a 100‐mg dose of either the test or reference tablet, with a 42‐day washout period between doses. Blood samples were collected at prespecified time points from 0 hour (before administration) to 984 hours after administration. Plasma concentrations of bedaquiline were measured using a validated ultra‐performance liquid chromatography‐tandem mass spectrometry method. Safety was monitored throughout the study. Key pharmacokinetic parameters included maximum plasma concentration, area under the plasma concentration‐time curve (AUC) from 0 to 72 hours, AUC from time 0 to the last measurable concentration, AUC from 0 to 336 hours, and AUC from time 0 to infinity. The 90% confidence intervals for the geometric mean ratios of the test/reference formulations for maximum plasma concentration, AUC from 0 to 72 hours, AUC from 0 to 336 hours, AUC from time 0 to the last measurable concentration, and AUC from time 0 to infinity fell within the bioequivalence acceptance range of 80%‐125%. confirming bioequivalence between the 2 formulations in healthy Chinese volunteers. Moreover, a high‐fat diet can significantly elevate the exposure of bedaquiline. No serious adverse events occurred, and both formulations were well tolerated across all participants.
Three Party Post Quantum Secure Lattice Based Construction of Authenticated Key Establishment Protocol for Mobile Communication
Authors: Kumar Sunil , Mittal Gaurav , Yadav Arvind 
Published: January 2025

ABSTRACTA three‐party post‐quantum key agreement protocol involves server with two communicating parties securely agreeing on a shared secret key in a way that is resistant to quantum attacks. Once the shared secret key is shared using authenticated key agreement protocol, then user (A), and user (B) can use it for securing communication channel using symmetric‐key encryption AES‐256 algorithm. Although there are few third‐party post‐quantum authenticated and key agreement schemes exist, but the recent studies in this paper illustrates that they are not satisfying properties like unlinkability, anonymity, perfect forward secrecy, and signal leakage attacks. Therefore, the proposed protocol ensures anonymity, unlinkablity, perfect forward secrecy, and resistant against signal leakage attacks. The proposed protocol uses different random numbers for each of sessions and ensures freshness of the session key to maintain forward secrecy. In this protocol, the user (A) only communicates with server, and establish an authenticated session key with user (B) which avoids server overheads. The use of ring learning with errors (RLWE) instead of the simpler learning with errors (LWE) is primarily motivated by the need for efficiency, compactness, and scalability in cryptographic applications. A comparative study, including both performance and security assessments, demonstrates that the proposed design is more secure and efficient.
Integrating Embedding and LSHiForest in English Text Anomaly Detection
Authors: Tong Qingquan , Yao Rongju 
Published: January 2025

ABSTRACTIn the realm of natural language processing (NLP), anomaly detection plays a critical role in identifying irregularities and outliers within textual data. Traditional methods often struggle with the high‐dimensional and sparse nature of text data, leading to inefficiencies in detecting meaningful anomalies, especially in the big data application context. To address these challenges, this paper proposes the integration of LSHiForest (Locality‐Sensitive Hashing Isolation Forest) into the process of English text anomaly detection. LSHiForest, which synergistically combines the dimensionality reduction capabilities of locality‐sensitive hashing (LSH) with the robust outlier detection of Isolation Forest, offers a novel approach to handling the complexities of textual data. The proposed approach involves transforming English text into feature vectors, followed by the application of LSHiForest to detect anomalies across various text datasets. The effectiveness of this approach is evaluated through comparative experiments with traditional anomaly detection methods, with various performance metrics. The experimental results demonstrate that LSHiForest significantly improves the efficiency and accuracy of outlier identification in English text, particularly in scenarios involving large‐scale and high‐dimensional datasets.
The Effects of Grain Size on the Mechanical Properties of Nanocrystalline NiCoFe Nickel‐Based Medium Entropy Alloys
Authors: Lu Xuefeng , Chang Yajun , Qiu Zihan , Gong Shengli , Zhang Kexin , Yin Jiangtao , Ren Junqiang , Guo Xin 
Published: January 2025

AbstractThe effects of nanocrystalline NiCoFe nickel‐based medium entropy alloys on tensile mechanical properties as a function of increasing Fe/Co ratio are investigated by simulation methods. Ni60Co10Fe30 exhibits higher strength and is employed to investigate the effects of grain size on mechanical properties. The results reveal that a decrease in grain size leads to a reduction in Young's modulus, and the work‐hardening phenomenon is more pronounced in larger grain size samples compared to those with smaller grain sizes. The critical grain size for the transition from the Hall‐Petch relationship to the inverse Hall‐Petch effect is ≈9.65 nm. In the former region, the hindering effect of grain boundaries on dislocations results in an increase in average flow stress as grain size decreases, with dislocation motion serving as the primary deformation mechanism. In the latter phase, the softening effect associated with grain boundary migration leads to a decrease in alloy strength as grain size diminishes, indicating that grain boundary migration serves as the dominant deformation mechanism. These findings elucidate the critical role of grain size in the mechanical properties of NiCoFe alloys and have significant implications for the design of high‐performance medium entropy alloys.