bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of pharmacy‐led interventions: identification of facilitators and barriers for the design of a new model of care for asthma
Authors: Rajballi‐Naidoo Neera , Wilby Kyle John , Young Amber , Smith Alesha 
Published: August 2023

AbstractThe objective of this narrative review was to determine the facilitators and barriers identified in pharmacy‐led interventions that improve outcomes in patients with asthma and support the implementation of interventions in practice. EMBASE, Web of Science, Google Scholar, and PubMed were used to identify 17 relevant articles. Seven studies were randomised controlled studies and 10 were one‐arm, pre‐post evaluations of all participants enrolled. Questionnaires assessing asthma control, medicine adherence, and knowledge about asthma were used, while checklists were used to assess inhaler technique. Studies with planned interventions in a clinic or general practice setting and lasting for 6 months (compared to longer interventions of 48 weeks) were more successful in retaining participation in the program. Education was the key intervention in which inhaler technique training was the most common. Knowledge about the disease, its aetiology, trigger factors, and medication used were covered in 10 of the studies. Fifteen of the articles reported an improvement in the asthma of patients receiving intervention by the pharmacist, measured by their asthma control test scores, emergency department visits, or reduced emergency steroid prescriptions. This review highlights five key requirements for the success of pharmacy‐based interventions for asthma management: (a) developing and maintaining a skilled workforce; (b) close proximation of a general practitioner practice or clinic to the pharmacy; (c) patient education on the disease and medicine; (d) structured and standardised intervention and assessment; and (e) length of the intervention suitable to the pharmacist and the patient.
Cover Image
Authors: Guo Mingming , Qin Yujie , Sun Hezhi , Li Zhaoqun , Zhang Xinzhong , Wang Xinru , Yang Mei , Luo Fengjian , Chen Zongmao , Zhou Li 
Published: August 2023

The cover image is based on the Research Article Method validation for detection of afidopyropen and M440I007 in tea by Mingming Guo et al., https://doi.org/10.1002/jsfa.12691.image
A deep learning‐based simulator for comprehensive two‐dimensional GC applications
Authors: Minho Lucas Almir Cavalcante , Cardeal Zenilda de Lourdes , Menezes Helvécio Costa 
Published: August 2023

Among the main approaches for predicting the spatial positions of eluates in comprehensive two‐dimensional gas chromatography, the still under‐explored computational models based on deep learning algorithms emerge as robust and reliable options due to their high adaptability to the structure and complexity of the data. In this work, an open‐source program based on deep neural networks was developed to optimize chromatographic methods and simulate operating conditions outside the laboratory. The deep neural networks models were fit to convenient experimental predictors, resulting in scaled losses (mean squared error) equivalent to 0.006 (relative average deviation = 8.56%, R2 = 0.9202) and 0.014 (relative average deviation = 1.67%, R2 = 0.8009) in the prediction of the first‐ and second‐dimension retention times, respectively. Good compliance was observed for the main chemical classes, such as environmental contaminants: volatile, semivolatile organic compounds, and pesticides; biochemistry molecules: amino acids and lipids; pharmaceutical industry and personal care products and residues: drugs and metabolites; among others. On the other hand, there is a need for continuous database updates to predict retention times of less common compounds accurately. Thus, forming a collaborative database is proposed, gathering voluntary findings from other users.
A novel pillar[3]trianglimine macrocycle with a deep cavity used as a chiral selector to prepare a chiral stationary phase by thiol‐ene click reaction for enantioseparation in high‐performance liquid chromatography
Authors: Liang Rui‐Xue , Ma Qi‐Yu , Xiang Tuan‐Xiu , Zhang You‐Ping , Gong Ya‐Nan , Huang Bin , Wang Bang‐Jin , Xie Sheng‐Ming , Zhang Jun‐Hui , Yuan Li‐Ming 
Published: August 2023

A chiral pillar[3]trianglimine (C60H72N6O6) with a deep cavity has been developed as a chiral selector and bonded to thiolated silica by thiol‐ene click reaction to fabricate a novel chiral stationary phase for enantioseparation in high‐performance liquid chromatography. The enantioseparation performance of the fabricated chiral stationary phase has been evaluated by separating various racemic compounds, including alcohols, esters, amines, ketones, amino acids, and epoxides, in both normal‐phase and reversed‐phase elution modes. In total, 14 and 17 racemates have been effectively separated in these two separation modes, respectively. In comparison with two widely used chiral columns (Chiralcel OD‐H and Chiralpak AD‐H), our novel chiral stationary phase offered good chiral separation complementarity, separating some of the tested racemates that could not be separated or were only partially separated on these two commercial columns. The influences of analyte mass, mobile phase composition, and column temperature on chiral separation have been investigated. Good repeatability, stability, and column‐to‐column reproducibility of the chiral stationary phase for enantioseparation have been observed. After the fabricated column had been eluted up to 400 times, the relative standard deviations (n = 5) of resolution (Rs) and retention time of the separated analytes were < 0.39% and < 0.20%, respectively. The relative standard deviations (n = 3) of Rs and retention time for column‐to‐column reproducibility were < 4.6% and < 5.2%, respectively. This study demonstrated that the new chiral stationary phase has great prospects for chiral separation in high‐performance liquid chromatography.
Introduction to the Special Section on the International Society for Traumatic Stress Studies 38th Annual Meeting: Trauma as a transdiagnostic risk factor across the lifespan
Authors: Carter Sierra E. , Sumner Jennifer A. 
Published: August 2023

AbstractThis article serves as an introduction to the special section in the Journal of Traumatic Stress related to the 38th annual meeting of the International Society for Traumatic Stress Studies, held in Atlanta, Georgia (USA) in November 2022. The theme of this meeting, “Trauma as a Transdiagnostic Risk Factor Across the Lifespan,” provided an opportunity to recognize the far‐reaching impact of trauma and how traumatic experiences can become embedded into the mind, body, and societal spirit. This introductory article outlines the importance of harnessing multiple perspectives to address these wide‐ranging sequelae of trauma and provides an overview of the series of contributions to the special section.
Unmet clinical needs, burden of disease and treatment patterns in hidradenitis suppurativa: Real‐world experience from Spain
Authors: Vilarrasa Eva , Molina‐Leyva Alejandro , Martín Víctor , Coak Emily , Truman Isabel , Wallinger Hayley , Richardson Craig , Martorell Antonio 
Published: August 2023

AbstractBackgroundHidradenitis suppurativa (HS) is a chronic, inflammatory, debilitating skin disease. HS is difficult‐to‐treat, and a multifaceted treatment approach is recommended to achieve adequate clinical response. A greater understanding of HS treatment could help identify unmet clinical needs.ObjectivesTo evaluate disease characteristics and treatment patterns in a real‐world population of patients with HS in Spain.MethodsThis retrospective analysis utilised data collected from the Adelphi HS Disease Specific Programme between November 2020 and April 2021. Dermatologists completed patient record forms (PRFs) for consulting HS patients. Outcomes included disease severity, HS clinical signs, quality of life measures, medical treatments and previous surgeries.ResultsOverall, 53 dermatologists completed 332 PRFs, each representing one patient with HS. Based on physician‐judged disease severity at sampling, 73.8%, 22.9% and 3.3% of patients were classified as mild, moderate or severe, respectively. Overall, patients presented with 2.8±2.7 (mean±SD) HS symptoms, which increased with worsening disease severity. The most frequently reported symptoms were ‘inflammation/redness of HS lesions/abscess’ (45.9%), general pain/discomfort (39.9%) and pain on sitting (32.3%). Overall, patients reported a mean±SD Dermatology Life Quality Index score of 4.7±4.8, which increased with worsening disease severity (mild, 3.9±4.3; moderate, 8.7±5.1; moderate to severe, 9.0±5.1). When asked what effect HS had on everyday activities, a large proportion of patients reported that HS sometimes or greatly affected personal appearance/self‐confidence (66.0%), mood (60.2%), close personal relationships (60.4%), motivation (38.3%), leisure activities (43.0%) and feelings about the future (33.6%). At the time of HS diagnosis, the most frequently prescribed treatment regimens were topicals (70.7%), antibiotics (57.6%) and antiseptics (32.2%). At the time of sampling, the most common treatment regimens were biologics (43.8%), topicals (34.9%) and antibiotics (32.2%). The mean±SD number of surgical interventions was 0.6±0.8; incision and drainage (31.3%), local or limited excision (13.0%), and wide surgical excision of all hair‐bearing skin (9.9%) were the most common surgeries.ConclusionsThese real‐world data suggest a high disease burden in patients with HS in Spain. Patients received multiple treatments, and a notable proportion underwent surgery. More data are needed to define optimal HS management strategies.
Trends in Twitter Utilization Among Academic Otolaryngologists
Authors: Duggal Radhika , Mehrabi Shadi , Bryson Paul C. , Bowe Sarah N. 
Published: August 2023

ObjectiveTo characterize Twitter utilization among academic otolaryngologists and evaluate the relationship between Twitter utilization and research productivity.MethodsData were collected manually from accredited US otolaryngology residency programs from July–November 2021. Program and faculty demographics were documented, including citations and H‐index for faculty and Doximity reputation and US News and World Report ranking for programs. Twitter metrics were also recorded. Descriptive analyses and multivariable logistic regression models were used to identify predictors of Twitter utilization.ResultsCurrently, 333 (16%) faculty and 70 (62%) programs have a Twitter account. Of these, 36 (11%) and 27 (39%), respectively, were created in 2020. The regression model indicates that for each 5 unit increase in H‐index, the odds of having a Twitter account increase 22% (OR 1.22, 95% CI 1.10–1.34, p = 0.0009). The number of faculty with a Twitter account predicts the existence of program Twitter accounts (OR:1.49, 95% CI 1.01–2.19, p = 0.04). Finally, of the 323 faculty with a Twitter account and available Scopus profile, we found that the number of individuals with Twitter use out of proportion to their academic productivity was low (n = 8/323).ConclusionThe H‐index is a significant predictor of faculty Twitter accounts, whereas the number of faculty with Twitter is a significant predictor of program Twitter utilization. Although Twitter utilization is increasing, especially during the coronavirus pandemic, the findings indicate that there is ample room for growth, particularly amongst faculty with strong academic portfolios.Level of EvidenceNA Laryngoscope, 134:1190–1196, 2024
Soil aggregation and aggregate‐associated organic carbon flows are affected by different restoration patterns on reclaimed mine soil in the Loess Plateau of China
Authors: Bi Yinli , Li Mingchao , Du Xinpeng , Christie Peter 
Published: August 2023

AbstractVegetation restoration of land post‐mining can strengthen the development of soil aggregates and promote the accumulation of soil organic carbon (SOC), and Microbial restoration such as Arbuscular mycorrhizal fungi (AMF) can significantly improve the effect of vegetation restoration. However, the effects of different recovery modes (microbial and natural restoration) on soil macroaggregates development and the carbon flows of the organic carbon (OC) have been less studied on reclaimed mine soil. A 4‐year field experiment was conducted on opencast coal reclaimed areas in Inner Mongolia grassland, and three recovery modes were set up: artificial restoration, artificial restoration (inoculated with AMF) and natural restoration. Results showed that compared with the natural restoration, artificial restoration and AMF inoculation increased the OC, total glomalin‐related soil proteins (TGRSP) contents and the value of δ13C in macroaggregates (>0.25 mm) in deep soil (30–50 cm). The shallow roots were the most likely starting points of carbon flow in the natural recovery area surface soil, and artificial restoration inoculation with AMF increased the carbon flows between all levels of aggregates in deep soil, showing a carbon flow pattern from macroaggregates to microaggregates (<0.25 mm). Moreover, significant correlations among the TGRSP, SOC content, and δ13C value were recorded, indicating the SOC sequestration and stability of reclaimed mine soil were potentially associated with TGRSP. In summary, both natural restoration and artificial restoration had advantages and disadvantages on reclaimed mine soil, but the artificial restoration inoculation with AMF showed great potential in promoting the aggregate carbon flow and persistent SOC accumulation.
There is no such thing as a predatory journal
Authors: Downes Mike 
Published: August 2023

Key points
A journal is inanimate and incapable of predation, hence there is no such thing as a predatory journal.
The predators are the publishing company CEOs, journal owners and other complicit people.
Those committing fraud and identity theft should be prosecuted.
Less time and effort should be spent on scholarly investigations.
More time and effort should now be devoted to prosecutions.
The physiological response of an Antarctic key phytoplankton species to low iron and manganese concentrations
Authors: Balaguer Jenna , Thoms Silke , Trimborn Scarlett 
Published: August 2023

AbstractIron (Fe) and manganese (Mn) availability and the divergent requirements of phytoplankton species were recently shown to be potential important drivers of Southern Ocean community composition. Knowledge about Antarctic phytoplankton species requirements for Fe and Mn remains, however, scarce. By performing laboratory experiments and additional calculations of the photosynthetic electron transport, we investigated the response of the ecologically important species Phaeocystis antarctica under a combination of different Fe and Mn concentrations. Fe deprivation alone provoked typical physiological characteristics of Fe limitation in P. antarctica (e.g., lowered growth and photosynthetic efficiency). In comparison, under Mn deprivation alone, the growth and carbon production of P. antarctica were not impacted. Its tolerance to cope with low Mn concentrations resulted from an efficient photoacclimation strategy, including a higher number of active photosystems II through which fewer electrons were transported. This strategy allowed us to maintain similar high growth and carbon production rates as FeMn‐enriched cells. Due to its low Mn requirement, P. antarctica performed physiologically as Fe‐deprived cells under the combined depletion of Fe and Mn. Hence, our study reveals that different from other Southern Ocean phytoplankton species, P. antarctica possesses a high capacity to cope with natural low Mn concentrations, which can facilitate its dominance over others, potentially explaining its ecological success across the Southern Ocean.
Spontaneous and Microbiota‐Driven Degradation of Anthocyanins in an In Vitro Human Colon Model
Authors: Shehata Emad , Day‐Walsh Priscilla , Kellingray Lee , Narbad Arjan , Kroon Paul A. 
Published: August 2023

ScopeThe consumption of dietary anthocyanins is associated with various health benefits. However, anthocyanins are poorly bioavailable, and most ingested anthocyanins will enter the colon where they are degraded to small phenolic metabolites that are the main absorbed forms. Little is known about the processes of anthocyanin degradation in the gut and the role of the human gut microbiota. This study aims to determine the contribution of spontaneous and microbiota‐dependent degradation of anthocyanins in the human colon.Methods and resultsPurified anthocyanin extracts from black rice and bilberry were incubated in an in vitro human fecal‐inoculated pH‐controlled colon model over 24 h and anthocyanins were analyzed using HPLC‐DAD. The study shows that the loss of anthocyanins occurs both spontaneously and as a consequence of metabolism by the gut microbiota. The study observes that there is high variability in spontaneous degradation but only modest variation in total degradation, which included the microbiota‐dependent component. The degradation rate of anthocyanins is also shown to be dependent on the B‐ring substitution pattern and the type of sugar moiety, both for spontaneous and microbiota‐dependent degradation.ConclusionAnthocyanins are completely degraded in a model of the human colon by a combination of spontaneous and microbiota‐dependent processes.
A user independent denoising method for x‐nuclei MRI and MRS
Authors: Christensen Nichlas Vous , Vaeggemose Michael , Bøgh Nikolaj , Hansen Esben S. S. , Olesen Jonas L. , Kim Yaewon , Vigneron Daniel B. , Gordon Jeremy W. , Jespersen Sune N. , Laustsen Christoffer 
Published: August 2023

AbstractPurposeX‐nuclei (also called non‐proton MRI) MRI and spectroscopy are limited by the intrinsic low SNR as compared to conventional proton imaging. Clinical translation of x‐nuclei examination warrants the need of a robust and versatile tool improving image quality for diagnostic use. In this work, we compare a novel denoising method with fewer inputs to the current state‐of‐the‐art denoising method.MethodsDenoising approaches were compared on human acquisitions of sodium (23Na) brain, deuterium (2H) brain, carbon (13C) heart and brain, and simulated dynamic hyperpolarized 13C brain scans, with and without additional noise. The current state‐of‐the‐art denoising method Global‐local higher order singular value decomposition (GL‐HOSVD) was compared to the few‐input method tensor Marchenko‐Pastur principal component analysis (tMPPCA). Noise‐removal was quantified by residual distributions, and statistical analyses evaluated the differences in mean‐square‐error and Bland–Altman analysis to quantify agreement between original and denoised results of noise‐added data.ResultsGL‐HOSVD and tMPPCA showed similar performance for the variety of x‐nuclei data analyzed in this work, with tMPPCA removing ˜5% more noise on average over GL‐HOSVD. The mean ratio between noise‐added and denoising reproducibility coefficients of the Bland–Altman analysis when compared to the original are also similar for the two methods with 3.09 ± 1.03 and 2.83 ± 0.79 for GL‐HOSVD and tMPPCA, respectively.ConclusionThe strength of tMPPCA lies in the few‐input approach, which generalizes well to different data sources. This makes the use of tMPPCA denoising a robust and versatile tool in x‐nuclei imaging improvements and the preferred denoising method.
The effects of intervention with intravenous edaravone in Study 19 on hospitalization, tracheostomy, ventilation, and death in patients with amyotrophic lateral sclerosis
Authors: Brooks Benjamin Rix , Pioro Erik P. , Sakata Takeshi , Takahashi Fumihiro , Hagan Melissa , Apple Stephen 
Published: August 2023

AbstractIntroduction/AimsIntravenous (IV) edaravone is a US Food and Drug Administration–approved treatment for amyotrophic lateral sclerosis (ALS), shown in clinical trials to slow physical functional decline. In this study we compared the effect of IV edaravone (edaravone‐first group) versus placebo followed by IV edaravone (placebo‐first group) on survival and additional milestone events.MethodsThis work is a post hoc analysis of Study 19/MCI186‐19, which was a randomized, placebo‐controlled, phase 3 study investigating IV edaravone versus placebo. Study 19 and its 24‐week extension have been described previously (NCT01492686). Edaravone‐first versus placebo‐first group time to events for specific milestone(s) were analyzed post hoc. Time‐to‐event composite endpoints were time to death; time to death, tracheostomy, or permanent assisted ventilation (PAV); and time to death, tracheostomy, PAV, or hospitalization.ResultsThe risk for death, tracheostomy, PAV, or hospitalization was 53% lower among patients in the edaravone‐first vs placebo‐first groups (hazard ratio = 0.47 [95% confidence interval 0.25 to 0.88], P = .02). The overall effect of IV edaravone on ALS progression could be seen in the significant separation of time‐to‐event curves for time to death, tracheostomy, PAV, or hospitalization. ALS survival composite endpoint analyses (ALS/SURV) suggested a treatment benefit (least‐squares mean difference) for the edaravone‐first versus the placebo‐first group at week 24 (0.15 ± 0.05 [95% confidence interval 0.06 to 0.25], P < .01) and week 48 (0.11 ± 0.05 [95% confidence interval 0.02 to 0.21], P = .02).DiscussionThese analyses illustrate the value of timely and continued IV edaravone treatment, as earlier initiation was associated with a lower risk of death, tracheostomy, PAV, or hospitalization in patients with ALS.
Engaging a new generation of donors: A relationship management theory approach to communication between nonprofits and millennials
Authors: Parker Kimberly A. , Geegan Sarah A. , Pfeiffer Samantha N. , George Ansley M. , Jaffe Danielle E. , Grumbein Adriane , Scheuer Sylvia , Brown Allison D. 
Published: August 2023

AbstractCurrent evidence on philanthropic giving to nonprofit organizations (NPOs) suggests that NPOs are not successfully cultivating relationships with prospective donors in the millennial generation; this has negative implications for the organizations' future financial sustainability. The current investigation employed a framework grounded in relationship management theory to explore how NPOs can better engage with this target audience. A series of focus groups revealed nuanced factors that facilitated relationship‐building between millennials and NPOs, rooted in the theoretical constructs of trust and openness. These results can be used to guide NPOs' donor‐engagement strategies focused specifically on millennials, thus guiding long‐term donor relations efforts.
Solar parks as livestock enclosures can become key to linking energy, biodiversity and society
Authors: Zaplata Markus K. 
Published: August 2023

Abstract

The expansion of renewable energy generation sites in the landscape is controversial, as is repopulation by large predators, particularly wolves. Both range extensions are recent phenomena, and both lead to harsh incompatibilities that arise from exclusions.

Regarding solar parks, the problems would be solvable by a paradigm shift, namely towards inclusions. The required changes sound trivial: First, it would be more multifunctional to make use of the valuable plant growth in solar parks. Second, it would be more sustainable to rely on grazing rather than mowing for solar park maintenance. Grazing livestock would need to be protected from wolves by strong fencing.

If these changes become the reality, this could locally remove large predators like the wolf from the line of fire of social resistance. In addition, implementation would bring benefits across sectors by bringing together previously divergent and hardened utilization concepts, which would ultimately have positive impacts for renewable energy generation, biodiversity and society.

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