bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rotten to the core – a neurofunctional signature of subjective core disgust generalizes to socio-moral contexts
Authors: Gan Xianyang , Zhou Feng , Xu Ting , Liu Xiaobo , Zhang Ran , Zheng Zihao , Yang Xi , Zhou Xinqi , Yu Fangwen , Li Jialin , Cui Ruifang , Wang Lan , Yuan Jiajin , Yao Dezhong , Becker Benjamin 
Published: June 2023

Abstract
While disgust originates in the hard-wired mammalian distaste response, the conscious experience of disgust in humans strongly depends on subjective appraisal and may even extend to sociomoral contexts. In a series of studies, we combined functional magnetic resonance imaging (fMRI) with machine-learning based predictive modeling to establish a comprehensive neurobiological model of subjective disgust. The developed neurofunctional signature accurately predicted momentary self-reported subjective disgust across discovery (n=78) and pre-registered validation (n=30) cohorts and generalized across core disgust (n=26) and sociomoral (unfair offers; n=43) contexts. Disgust experience was encoded in distributed cortical and subcortical systems, and exhibited distinct and shared neural representations with subjective fear or negative affect in interoceptive-emotional awareness and conscious appraisal systems while the signatures most accurately predicted the respective target experience. We provide an accurate fMRI-signature for disgust with a high potential to resolve ongoing evolutionary and clinical debates.
Long-term cognitive outcomes in Susac syndrome
Authors: Piura Yoav , Bregman Noa , Kave' Gitit , Karni Arnon , Kolb Hadar , Vigiser Ifat , Shiner Tamara , Regev Keren 
Published: June 2023

Abstract
Background
Susac syndrome (SuS) is a rare autoimmune disorder mediated by the occlusion of micro-blood vessels in the brain, retina, and inner ear. Approximately 15% of cases present with the classic triad of CNS dysfunction, visual disturbances, and sensorineural hearing loss. While the literature is abundant about the severe, acute encephalopathy of SuS, not much is known about the extent of cognitive sequela in the post-era of efficient immunomodulatory treatment.
Methods
We report global cognitive function using a battery of cognitive tests in ten recovering SuS patients with an average of 2.9 (SD = 1.41) years post-disease onset.
Results
Patients showed intact delayed memory (both verbal and non-verbal) but below-average scores on tests of executive functions, and deficits in attention and copying. Results are discussed in light of the initial severity and extent of corpus callosum involvement on brain MRI.
Conclusions
study results suggest that the main cognitive sequela of SuS involves deficits in visual attention and executive functions possibly due to Corpus Callosum involvement. Additionally, this report supports a favorable prognosis for patients with SuS who receive a fast and efficacious immunomodulatory treatment protocol suggested in 2018.
Mobile health (mHealth) interventions for psychiatry in Switzerland and Russia: a comparative study
Authors: Chivilgina Olga , Elger Bernice S. , Fedotov Ilya , Jotterand Fabrice 
Published: June 2023

Abstract
During the past decade, the use of digital technology to promote mental health has increased dramatically. Additionally, the consequences of the COVID pandemic, such as travel restrictions and the disruption of face-to-face interactions, have led to an increase in the usage of digital technologies. A wide variety of technologies have been developed, ranging from messaging chat bots to virtual reality technologies and from direct-to-consumer apps to technologies that are fully integrated into clinical care tools. Russia and Switzerland have not been blind spots on the map of such technologies. However, the use of digital technology to promote mental health has taken different paths in these two healthcare settings. The following study is based on the opinions of mental health specialists in both countries in 2019–2020 regarding the use of digital health technologies in psychiatry. We investigate the state of adoption of digital technologies in the field of mental health, the meaning of such technology and the factors that are crucial to the use of such technology in psychiatry. Our study also explores the structural and legal barriers to technology adoption in Switzerland and Russia.
B7H3 Targeting Gold Nanocage pH-Sensitive Conjugates for Precise and Synergistic Chemo-Photothermal Therapy against NSCLC
Authors: Chen Bing , Zheng Kaifan , Fang Shubin , Huang Kangping , Chu Chengchao , Zhuang Junyang , Lin Jin , Li Shaoguang , Yao Hong , Liu Ailin , Liu Gang , Lin Jizhen , Lin Xinhua 
Published: June 2023

Abstract
Background: The strategy of combining a drug delivery with an immune checkpoint target has been widely investigated in cancer therapy, but the remarkable benefit to patients from this strategy is still limited. B7 homolog 3 protein (B7-H3), also known as CD276 (B7-H3/CD276), is a promising anti-cancer therapeutic target that is broadly overexpressed on the surface of malignant cells and tumor vasculature, that is, associated with poor prognosis. Herein, we report B7H3 targeting doxorubicin (Dox)-conjugated gold nanocages (B7H3/Dox@GNCs) with pH-responsive drug release as a selective, precise, and synergistic chemotherapy-photothermal therapy agent against non-small-cell lung cancer (NSCLC).
Results: In vitro, B7H3/Dox@GNCs showed tumor acidic microenvironment responsive Dox release, enhanced intracellular uptake, promoted cell cycle arrest, and increased apoptosis in B7H3 overexpressing NSCLC cells. B7H3/Dox@GNCs also exhibited tumor tissue targeting and acidic environment responsive sustained drug release in xenograft tumor models, wherein they synchronously destroyed B7H3 positive tumor cells, tumor-associated vasculature, and stroma fibroblasts.
Conclusion: This study presents a dual-compartment targeted B7H3 multifunctional gold conjugate system that can precisely control Dox exposure in a spatio-temporal manner without evident toxicity and suggests a general strategy for synergistic therapy against NSCLC.
Whether the wobbling W156 is a pre-requisite for efficient PET biodegradation by IsPETase
Authors: Yin Qingdian , Zhang Jiaxing , Ma Sen , Gu Tao , Wang Mengfan , You Shengping , Ye Sheng , Su Rongxin , Wang Yaxin , Qi Wei 
Published: June 2023

Abstract
IsPETase displayed great potential for mitigating PET contamination under moderate temperatures attributed to its specific high activity towards PET, while rapid activity loss limited its commercial viability. Herein, a thermostable S92P/D157A variant (Tm=70.8 °C) was constructed, enabling a 109.3-fold increase in products released from amorphous PET depolymerization at 40 °C. Further depolymerization of untreated post-consumer PET in a 360-times expanded reaction system obtained 20.09 mM products (95.0% TPA). Crystal structure characterized the “wobbling” W156 residue fixed at substrate-binding conformation in S92P/D157A variant, which stabilized the enzyme structure and could provide steady interaction with the substrate. Further MD simulations cement the importance of conformation selection and the contribution of W156. The different structure-function relationship observed raised the question of “whether the wobbling W156 is a pre-requisite for efficient PET biodegradation”. Especially, the S92P/D157A variant could serve as a starting point for further engineering and a potential candidate for industrial PET depolymerization processes.
Incidentally discovered parathyroid lipoadenoma in thyroid surgery: a case report and review of the literature
Authors: Wang Yihan , yuan meiyu , chen yan , Fu Yantao 
Published: June 2023

Abstract
Background: Parathyroid lipoadenoma is a rare type of parathyroid adenoma, described as a single parathyroid adenoma with more than 50% fat on histologic examination and an unknown etiology, which is one of the rare causes of primary hyperparathyroidism. The difficulty of parathyroid lipoma is mainly diagnosed by preoperative imaging localization. We hope to arouse attention to the parathyroid adenoma which is difficult to locate through our case report.
Case Description: The patient was a middle-aged male with a body mass index (BMI) of 38.4 who admitted to our hospital with a 40-day history of an untreated thyroid nodule. We incidentally discovered parathyroid lipoadenoma in his thyroid surgery. His prognosis was good, and there were no signs of recurrence at his 12-month follow-up appointment.
Conclusions: We believe that parathyroid lipoadenoma needs to rely on paraffin pathology to make a final diagnosis.This case report serves as a reminder that patients with preoperative unprovoked primary hyperparathyroidism and negative imaging findings may have a parathyroid lipoadenoma. During intraoperative thyroidectomy or lymph node dissection, it is important to carefully examine the adipose tissue for the possibility of parathyroid lipoadenoma, as this can lead to postoperative hypoparathyroidism or even intractable hypocalcemia.
Serum electrolyte imbalance in severely malnourished children at hospitals in North-central Ethiopia
Authors: Seid Mohammed Abdu , Adella Getachew Asmare , Kassie Gizchew Ambaw , Mengstie Misganaw Asmamaw , Dejenie Tadesse Asmamaw , Zemene Melkamu Aderajew , Dessie Anteneh Mengist , Kebede Yenealem Solomon , Bantie Berihun , Bayih Wubet Alebachew , Abebe Endeshaw Chekol , Gesese Molalegn Mesele , Feleke Sefineh Fenta , Anley Denekew Tenaw 
Published: June 2023

Abstract

Background – Severe acute malnutrition (SAM) raises the risk of death and disability associated with diarrhea owing to electrolyte depletion. Children with SAM have severely disrupted physiology and metabolism, and if vigorous refeeding begins before metabolic and electrolyte imbalances have been resolved, fatality rates are significant. No study has been conducted in Ethiopia on this topic, so this study was aimed at assessing electrolyte imbalance and its associated factors in under-5 children with severe acute malnutrition.
Methods – Hospital-based case control study was conducted at south Gondar Hospitals from October to December, 2021. Children under-went physical examination and had blood drawn for serum glucose, hemoglobin and electrolytes investigation. A semi-structured questionnaire consisting socio-demographic, clinical and personal variable as well as associated factors for electrolyte imbalance was applied. Both bi-variable and multivariable binary logistic regression analyses was performed. Both bi-variable and multivariable logistic regression were done. We performed crude odds ratio and adjusted odds ratio at 95% CI. In the final model, variables with a p-value < 0.05 was declared as statistically significant.
Result – We enrolled 232 children (116 cases and 116 controls). The mean age was 38.0 (SD±12.8) for cases and 37.1 (SD±13.1) for controls respectively. Sixty-one (52.6%) cases and 66 (56.9%) controls were female participants respectively. Hypokalemia [26.7%,16.4%]) and hyponatremia [25%, 14.7%] were frequently seen among cases and controls respectively. Death was recorded in 11 (9.5%) of cases. Edema (AOR=2.3; 1.4-4.7), not-vaccinated (AOR=1.2; 0.3-2.4) and diarrhea (AOR: 3.02; 1.09–8.63) were significantly associated with electrolyte derangement.
Conclusion: Electrolyte derangements, specifically hypokalemia and hyponatremia, were common in malnourished children. Having edema, not being fully vaccinated, and diarrhea were independent determinants of electrolyte derangement in malnourished children. Electrolyte levels should be measured in all severely malnourished cases to detect asymptomatic electrolyte imbalance.
Assessing the potential of genetic resource introduction into elite germplasm: a collaborative multiparental population for Flint maize
Authors: Sanchez Dimitri , Allier Antoine , Sadoun Sarah Ben , Tristan Mary-Huard , Bauland Cyril , Palaffre Carine , Lagardère Bernard , Madur Delphine , Combes Valérie , Melkior Stephane , Bettinger Laurent , Murigneux Alain , Moreau Laurence , Charcosset Alain 
Published: June 2023

Abstract
Genetic diversity is crucial for maintaining genetic gains and ensuring breeding program’s long-term success. In a closed breeding program, selection inevitably leads to a loss of genetic diversity. While managing diversity can delay this loss, introducing external sources of diversity is necessary to bring back favorable genetic variation. Genetic resources exhibit greater diversity than elite materials, but their lower performance levels hinder their use. Establishing a bridging population that involves crosses between elite materials and diversity donors is a way to create improved genotypes that facilitate the incorporation in elite germplasm of original favorable variations coming from the donors.. Promising crosses in bridging populations can be identified thanks to their usefulness criterion (UC), which estimates progeny performance after selection, based on the average performance and the genetic variance of the cross. This paper documents experimentally these parameters in the framework of a collaborative multi-parental BC1-S2 population that includes materials from multiple breeding companies crossed to different donors. This program aims at enhancing the flint maize elite germplasm, which has only utilized so far a limited portion of the diversity available in genetic resources. Our findings show contrasted variances and UCs among crosses, resulting in an expected mean performance gain of 5% over the initial elite material. They make it possible to identify the most promising donor for each partner. They also suggest that one more generation, i.e. 3 in total, of crossing to the elite is required to fully exploit the potential of a donor.
Influence of How Rurality is Defined on Readmission Risk Factors for Younger Ischemic Stroke Survivors
Authors: Barfield LeeAnn , McGee Blake T. 
Published: June 2023

Abstract
Background.
Stroke is an expensive and destructive disease. Rural residence is linked to lower use of evidence-based stroke care interventions and higher risk of complications for stroke survivors. The purpose of this study was to examine predictors of 30-day readmission after acute ischemic stroke in patients aged 19–64 years and evaluate multiple specifications of rurality as risk factors for readmission.
Methods.
Data from the Healthcare Cost and Utilization Project for ischemic stroke survivors hospitalized during 2012–2015 were analyzed from six states. The urban influence code was utilized for patient location as an ordinal (large metropolitan, small metropolitan, micropolitan, or not metropolitan/micropolitan) and dichotomous variables. Logistic regression models of planned and unplanned readmission were built for each patient location variable.
Results.
After covariate adjustment, inhabitants of large metropolitan areas had higher odds of unplanned (but not planned) readmission compared to all others. However, the urban-rural distinction was not predictive of planned or unplanned readmission when specified any other way (any metro vs. non-metro, rural vs. all others, or as a 4-level ordinal variable).
Conclusions.
Urban-rural influence can be described as a predictor of unplanned readmission for younger ischemic stroke survivors when defined as large metropolitan areas compared to all others. The association between urban-rural location and unplanned readmission was sensitive to how urban-rural influence was operationalized. This finding demonstrates the importance of thoughtful attention to how rural and urban status are defined in research studies designed to document rural health disparities and interventions to address them.
Thinking about it: The impact of COVID-19 related stimuli on Prospective Memory
Authors: Vicentin Stefano , Cantarella Giovanni , Cona Giorgia , Bisiacchi Patrizia 
Published: June 2023

Abstract

Since 2020, information regarding COVID-19 has been a constant presence in the news and in our thoughts. Does this burden affect abilities essential to everyday functioning, such as Prospective Memory (PM), the ability to remember to perform an intention in the future? To answer this question, we proposed a PM paradigm composed of a Baseline and a PM conditions, between which a video clip was inserted. One of three possible video clips was displayed to each participant, presenting either neutral, negative, or COVID-related contents. To evaluate participants’ well-being and experience with the pandemic, the DASS-21 scale and the COVID-19-PTSD questionnaire were administered. A linear mixed effect (LME) model revealed a significant effect of the video on performance: participants that saw the COVID-related clip performed significantly better in the PM condition than participants in the other conditions, whereas the presentation of the video displaying negative contents was associated with decreased accuracy in the PM condition compared to the Baseline. Altogether, these results indicate a different effect of the exposure to “classical” negative contents (associated with decreased performance) and pandemic-related ones, that showed instead to improve accuracy. This counterintuitive finding seems to suggest that COVID-related stimuli are processed as “acute stressors” rather than negative stimuli. The explanatory power of the LME Model calculated on accuracy increased when the scores in the anxiety subscale of the DASS-21 were included suggesting a detrimental role of anxiety on our ability to perform a PM task.
Leucine rich repeat LGI family member 3: integrative analyses support its prognostic association with pancreatic adenocarcinoma
Authors: Yun Hye-Young 
Published: June 2023

Abstract
Leucine rich repeat LGI family member 3 (LGI3) is a member of the LGI protein family. Previous studies have reported that LGI3 serves as a multifunctional cytokine and is expressed in adipose tissue, skin, and brain tissue. LGI3 may also be involved in cytokine networks in various cancers. This study aimed to analyze differentially expressed genes in pancreatic adenocarcinoma (PAC) tissues and PAC cohort data in order to evaluate the prognostic role of LGI3. The expression microarray and the PAC cohort data were analyzed by bioinformatic methods for differential expression, protein-protein interactions, functional enrichment and pathway analyses, gene co-expression network analysis, and prognostic association analysis. Results showed that LGI3 expression was significantly reduced in PAC tissues. Nineteen upregulated genes and 31 downregulated genes in PAC tissues were identified as LGI3-regulated genes. Protein-protein interaction network analysis demonstrated that 92% (46/50) of the LGI3-regulated genes that were altered in PACs belonged to a protein-protein interaction network cluster. Functional enrichment and gene co-expression network analyses demonstrated how these genes were associated with various processes including inflammatory and immune responses, metabolic processes, cell differentiation, and angiogenesis. PAC cohort analyses revealed that low expression levels of LGI3 were significantly associated with poor PAC prognosis. Analysis of favorable or unfavorable prognostic gene products in PAC showed that 93 LGI3-regulated genes were differentially associated with PAC prognosis. Taken together, these results suggested that LGI3 may be a potential prognostic marker of PAC.
Anchorage mechanism of bamboo-steel composite rockbolts subjected to the coupled effect of tensile and shear stress
Authors: Ren Feifan , Huang Qiangqiang , Wang Guan , Li Zhuang 
Published: June 2023

Abstract
Earthen heritage sites are of high cultural and scientific value. However, most of earthen heritage sites have been severely damaged and are in urgent need of repair. To address this issue, a novel rockbolt, bamboo-steel composite rockbolt (BSCR), has been proposed and widely employed in earthen site protection. However, research on the anchorage mechanism of BSCR lags behind engineering practice, particularly with regard to its behavior under the coupled effect of tensile and shear stress. In this study, combined with centrifugal test results, a numerical model was established and validated and a comparative analysis of the anchorage mechanism between conventional rockbolt (CR) and BSCR was also conducted. The results show that BSCR with a larger diameter and bending stiffness is superior to CR in protecting earthen heritage sites. Moreover, reducing the rockbolt inclination angle and increasing the number of rockbolt layers can mitigate slope deformation resulting from the coupled effect of tensile and shear stress. Increasing the length of BSCR can enhance the stability of bolted slopes; however, excessive extending the rockbolt length is inefficient due to the effect of the effective anchorage length of the rockbolt. These findings provide valuable insights into the use of BSCR in earthen site protection and may provide a reference for further research on its anchorage mechanism under complex stress conditions.
IoT based Investigation of Augment March C _ Algorithm: Heuristic Approach
Authors: Mathur Vinita , Pundir Aditya Kumar , Singh Sanjay Kumar 
Published: June 2023

Abstract
In this paper an effective novel memory management strategies for IoT framework standard over MQTT with raspberry pi field protocol is used in RAID 6 (Redundant array of independent drives) for data storage. RAID 6 offers a long data retention time for archiving as well as it provides a high fault and drive failure tolerance rate. The probability of rebuild failure rate as proposed to 0.397%with RAID 5. In This paper we have proposed a memory management strategies based on IoT framework for effective testing and repairing. For this a novel memory testing approach i.e. Improvised March C- (IM-March C-) Algorithm has been used with cases 32*8*1, 64*8*1, 256*8*1 for certain predefined injected-random fault at certain location in a RAID 6. The presented work has been tested on SPARTAN 2E, SPARTAN 3E, VIRTEX 2, VIRTEX 4, VIRTEX 5. From the Results it is clear that proposed algorithm has better fault coverage, require less tracing time (0.14 sec) and better device utilization.