bluuebunny/crossref_metadata_2025_split huggingface dataset:
A meta‐analysis examined the effect of topical nursing application of antimicrobial as a prophylaxis for the stoppage of surgical wound infection in colorectal surgery
Authors: Wang Xue , Fu Liming , Guo Shaoning , Fang Xuedong 
Published: February 2023

AbstractTo assess the impact of topical antimicrobial (TA) as a prophylaxis for the stoppage of surgical wound infection (SWI) in colorectal surgery (CS), we lead a meta‐analysis. 9160 participants with CS were enrolled in the chosen studies; 4719 of them used TA, while 4441 served as controls. To assess the effectiveness of TA application in lowering SWIs following CS, odds ratios (OR) with 95% confidence intervals (CIs) were computed with a dichotomous technique with a fixed‐ or random‐effect model. Significantly lower SWIs post CS for TA as whole (OR, 0.50; 95% CI, 0.38–0.64; P < .001), gentamicin collagen sponge and beads (OR, 0.52; 95% CI, 0.32–0.86; P = .01), triclosan impregnated fascial suture (OR, 0.57; 95% CI, 0.38–0.84; P = .005), antibiotic powder, ointment, lavage, or injection for the abdominal wound (OR, 0.35; 95% CI, 0.21–0.59; P < .001), and ionised silver dressing on the closed abdominal wound (OR, 0.45; 95% CI, 0.27–0.77; P = .003) compared to control. Significantly lower SWIs post CS for TA as a whole, gentamicin collagen sponge and beads, triclosan impregnated fascial sutures, antibiotic powder, ointment, lavage, or injection for the abdominal wound, and ionised silver dressing on the closed abdominal wound compared with control. The low sample size of 8 out of the 39 included studies in this meta‐analysis calls for precaution when analysing the outcomes.
A critical review of the role of ettringite in binders composed of CAC–PC–C$ and CSA–PC–C$
Authors: Noor Lamiya , Tuinukuafe Atolo , Ideker Jason H. 
Published: February 2023

AbstractEttringite‐accelerated binders composed of CAC–PC–C$ (calcium aluminate cement–Portland cement–calcium sulfate) and CSA–PC–C$ (calcium sulfoaluminate cement–Portland cement–calcium sulfate) have been used widely for indoor applications, such as self‐leveling floor screeds, underlayment, and tile adhesives owing to their rapid setting, early strength gain, and shrinkage compensation properties. These properties also make these binders appealing candidates for outdoor rapid repair (e.g., highways, bridge decks, and airfield pavements). However, a central question remains: Does ettringite remain stable in outdoor exposure conditions? If so, which factors will contribute positively/negatively to the long‐term stability of ettringite in these systems? To address these questions, this critical review presents the current state of knowledge regarding the hydration of ternary binders composed of CAC–PC–C$ and CSA–PC–C$ with respect to ettringite formation and the factors affecting the stability of ettringite thereafter. The purpose of this review paper is to synthesize and analyze current research regarding conditions that promote or deter ettringite stability, establish what information is missing, unclear, or contradictory, and identify remaining research needs to address the identified knowledge gaps.
Change in Cutibacterium acnes phylotype abundance and improvement of clinical parameters using a new dermocosmetic product containing Myrtus communis and Celastrol enriched plant cell culture extracts in patients with acne vulgaris
Authors: Mias Céline , Thouvenin Marie Dominique , Gravier Eleonore , Dalmon Sandrine , Bouyer Karine , Alvarez Sandrine , Mengeaud Valerie , Ribet Virginie , Bessou‐Touya Sandrine , Duplan Hélène 
Published: February 2023

AbstractBackgroundAcne is a multifactorial chronic inflammatory disease of the pilosebaceous unit, where Cutibacterium acnes plays a main role. Recent papers demonstrated that specific C. acnes phylotypes were correlated with the severity of inflammatory acne and reported a specific loss of C. acnes phylotype diversity in this context.ObjectivesThe aim of this exploratory study was to evaluate the efficacy of a new dermocosmetic product containing Myrtus communis and Celastrol‐enriched plant cell culture extracts on C. acnes phylotype abundance and clinical parameters in subjects with mild to moderate acne vulgaris.MethodsCutibacterium acnes phylotype diversity was evaluated by single‐locus sequence typing sequencing on the nonlesional areas of the forehead, that is, areas excluding inflammatory lesions (papules and pustules) on day 1 (D1) and after 56 days (D57) of twice daily application of the dermocosmetic product on the whole face. Clinical efficacy on acne was also assessed by acne lesion counting and Global Evaluation Acne (GEA) score on D1 and D57.ResultsOur study confirmed the link between the presence of some C. acnes phylotypes and acne severity. The dermocosmetic cream was linked to a positive impact on C. acnes phylotypes: a significant decrease in pro‐pathogen phylotype IC and increase in nonpathogen phylotype IB were observed in the nonlesional areas of acne on D57 compared to D1. In parallel, the clinical results showed a significant decrease in inflammatory and comedonal acne lesions and a significant improvement in the acne severity according to the GEA score.ConclusionsThis study showed that the application of a new dermocosmetic product containing M. communis and Celastrol‐enriched plant cell culture extracts was linked to a change in the C. acnes phylotype abundance and an improvement in acne severity.
Development of a PCR assay for the specific identification of the fish pathogen Tenacibaculum piscium
Authors: Saldarriaga‐Córdoba Mónica , Araya‐León Henry , Irgang Rute , Avendaño‐Herrera Ruben 
Published: February 2023

AbstractTenacibaculosis is an emerging disease that severely affects salmonid farming in Chile, producing high mortalities and causing great economic losses. This work describes a novel PCR assay for the specific detection of Tenacibaculum piscium, a species recently described and identified in tenacibaculosis outbreaks in Norway and Chile. The designed primers amplified a 678‐bp fragment of the peptidase gene (peptidase M23 family) from T. piscium. This method is specific for T. piscium; no other chromosomal DNA amplification products were obtained for other Tenacibaculum species. In pure cultures, the PCR assay detected up to 500 pg of DNA, or the equivalent of 2.44 ± 0.06 × 104 CFU/ml. For seeded fish samples (i.e., gills, liver, kidney, and mucus), the sensitivity limit was 4.88 ± 0.11 × 106 CFU/g, sufficient to detect T. piscium in acute infections in fish. Notably, this sensitivity level was 100‐fold lower for DNA extracted from mucus samples. As compared to other existing methodologies (e.g., gene sequencing), the PCR approach described in this work allowed for the easiest detection of T. piscium in mucus samples obtained from challenged fish, an important outcome considering that the identification of this bacterium is difficult. Our results indicate that the designed specific primers and PCR method provide a rapid and specific diagnosis of T. piscium.
A comprehensive review on the application of ultrasound for the preservation of fruits and vegetables
Authors: Ahmad Faizan , Mohammad Zahra H. , Zaidi Sadaf , Ibrahim Salam A. 
Published: February 2023

AbstractUltrasound technology is a green and environment‐friendly technology that rarely causes thermal damage to food products. In this review, we present an overview of the application of ultrasound technology for the dehydration of food products, including pre‐treatments such as ultrasound, osmotic dehydration, and ultrasound‐assisted osmotic dehydration. Dehydration promotes the preservation of food products and increases the shelf life of the food products by reducing water activity. In addition, the ultrasound‐assisted drying of food products is highlighted. The influence of ultrasound and ultrasound‐assisted osmotic dehydration parameters on drying kinetics and food quality is also discussed. The application of pre‐treatments enhances the mass transfer rate, increases the drying rate and drying efficiency, reduces drying time, and helps to retain food properties such as texture and nutrition value. Generally, ultrasound and osmotic dehydration application decreases water activity, increases rehydration ability, improves product color, and reduces nutrient losses. To conclude, we have discussed the use of ultrasound applications for improving the quality and safety of produce before and after the drying process.
Effect of pesticide application on Salmonella survival on inoculated tomato leaves
Authors: Gu Ganyu , Murphy Claire M. , Hamilton Alexis M. , Zheng Jie , Nou Xiangwu , Rideout Steven L. , Strawn Laura K. 
Published: February 2023

AbstractOutbreaks of Salmonellosis have been traced to contaminated tomato. The produce production environment poses a risk for Salmonella contamination; however, little is known about the effects of pest management practices on Salmonella during production. The study objective was to evaluate pesticide application on the inactivation of Salmonella on tomato leaves. Thirty greenhouse‐grown tomato plants were inoculated with S. enterica serovars Newport or Typhimurium. Inoculation was performed by dipping tomato leaves in an 8‐log CFU/mL Salmonella suspension with 0.025% (vol/vol) Silwet L‐77 surfactant for 30 s, for a starting concentration of 6–7 log CFU/mL. Plants were treated with one of four pesticides, each with a different mode of action [acibenzolar‐S‐methyl, copper‐hydroxide, peroxyacetic acid (PAA), and streptomycin]. Pesticides were applied at manufacturers' labeled rate for plant disease management with water as a control treatment. Salmonella was enumerated at 0.125 (3 h), 2, 6, and 9 days post‐inoculation (dpi), and counts log‐transformed. Growth of Salmonella was not observed. At 2 dpi, PAA and streptomycin significantly reduced surface Salmonella concentrations of inoculated tomato leaves (0.7 and 0.6‐log CFU/g, respectively; p ≤ 0.05), while significant Salmonella log reduction occurred in the ground tomato leaves after copper hydroxide treatment (0.8‐log CFU/g; p ≤ 0.05), compared to the control. No significant differences in Salmonella populations on tomato leaf surface and in ground leaves were observed from 2 to 9 dpi, regardless of pesticide application. These findings suggest single in‐field pesticide applications may not be an effective mitigation strategy in limiting potential Salmonella contamination. Future research, including multiple in‐field pesticide applications, or pesticide use in combination with other mitigation strategies, may offer intriguing management practices to limit possible preharvest contamination.
Prolonged endocrine therapy in the management of hormone receptor‐positive early‐stage breast cancer: What is the appropriate duration?
Authors: Micha John P. , Rettenmaier Mark A. , Bohart Randy D. , Goldstein Bram H. 
Published: February 2023

AbstractAimThe clinical benefits associated with 5 years of endocrine therapy in the treatment of hormone receptor‐positive, early‐stage breast cancer (ESBC) have been well‐substantiated. However, numerous studies have reported on the results of extended (i.e., >5 years) endocrine therapy to further effectuate a clinical benefit, with varying outcomes. Hence, the purpose of this study is to review these prolonged investigations and endeavor to clarify their corresponding treatment implications.MethodsWe reviewed the study findings from several randomized controlled trials and meta‐analyses, which incorporated clinical outcomes from pre‐and postmenopausal, hormone receptor‐positive, ESBC patients.ResultsHormone receptor‐positive, ESBC patients treated with 5 years of endocrine therapy, who are node‐negative with tumors <2 cm, will unlikely benefit from five additional years of treatment. Conversely, in women with larger tumors and node‐positive disease, 7–8 total years of endocrine therapy may be indicated. Ultimately, clinicians should also consider the attendant side effects from endocrine therapy, namely bone fractures, namely cardiovascular symptoms, and vasomotor symptoms, when considering the appropriate treatment regimen.ConclusionsWhile increased duration of endocrine therapy may selectively accord significant clinical benefits, prior to determining the patient's treatment interval, physicians should also assess the cumulative side effects from endocrine therapy when endeavoring to maintain treatment compliance and bolster quality of life.
The impact of assisted reproductive technology on the risk of postpartum hemorrhage: Difference by the mode of delivery and embryo transfer
Authors: Yamamura Akitoshi , Okuda Akiko , Abe Akiko , Kashihara Yuki , Kozono Yuki , Sekiyama Kentaro , Yoshioka Yumiko , Higuchi Toshihiro 
Published: February 2023

AbstractAimThe frequency of postpartum hemorrhage (PPH) is increasing in developed countries, and some reports suggest that assisted reproductive technology (ART) increases various perinatal complications, including PPH. We investigated whether the effect of ART pregnancies on the incidence of PPH is modified by the mode of delivery.MethodsA retrospective cohort study was performed. We analyzed the medical records of 2914 pregnant women, including 411 pregnancies achieved by ART, which were delivered in our hospital from 2017 to 2020. PPH was defined as hemorrhage exceeding the 90th percentile of blood loss per the mode of delivery and number of fetuses. Multivariable logistic regression analysis was used to assess the association between ART and PPH. Propensity score‐matched analyses were used to assess the difference in the incidence of PPH by the mode of delivery.ResultsAs previously reported, multivariable logistic regression analysis showed that ART pregnancy is an independent risk factor for PPH. Propensity score‐matched analysis for with and without ART showed a 3.39‐fold higher incidence of PPH for ART pregnancy in the vaginal delivery group (p < 0.001).ConclusionsThe effect of ART pregnancies on the incidence of PPH differed depending on the mode of delivery. Only in vaginal delivery, ART pregnancy increased the incidence of PPH.
Enhancing claim classification with feature extraction from anomaly‐detection‐derived routine and peculiarity profiles
Authors: Duval Francis , Boucher Jean‐Philippe , Pigeon Mathieu 
Published: February 2023

AbstractUsage‐based insurance is becoming the new standard in vehicle insurance; it is therefore relevant to find efficient ways of using insureds' driving data. Applying anomaly detection (AD) to vehicles' trip summaries, we develop a method allowing to derive a “routine” and a “peculiarity” anomaly profile for each vehicle. To this end, AD algorithms are used to compute a routine and a peculiarity anomaly score for each trip a vehicle makes. The former measures the anomaly degree of the trip compared with the other trips made by the concerned vehicle, while the latter measures its anomaly degree compared with trips made by any vehicle. The resulting anomaly scores vectors are used as routine and peculiarity profiles. Features are then extracted from these profiles, for which we investigate the predictive power in the claim classification framework. Using real data, we find that features extracted from the vehicles' peculiarity profile improve the classification.
Ramelteon for delirium prevention in hospitalized patients: An updated meta‐analysis and trial sequential analysis of randomized controlled trials
Authors: Yu Chia‐Ling , Carvalho Andre F. , Thompson Trevor , Tsai Tzu‐Cheng , Tseng Ping‐Tao , Tu Yu‐Kang , Yang Szu‐Nian , Yang Fu‐Chi , Chang Cheng‐Ho , Hsu Chih‐Wei , Hsu Tien‐Wei , Liang Chih‐Sung 
Published: February 2023

AbstractAlthough ramelteon has been examined as a relatively new therapeutic option for delirium prevention, current evidence to evaluate its efficacy is limited. We conducted an updated meta‐analysis and examine the reliability of existing evidence regarding the effect of ramelteon on delirium prevention in hospitalized patients. Seven major electronic databases were systematically searched to identify randomized controlled trials examining the efficacy of ramelteon in delirium prevention. Data were pooled using a frequentist‐restricted maximum‐likelihood random‐effects model. A trial sequential analysis was performed using relative risk reduction thresholds of 50%. The primary outcome was the incidence of delirium (reported as odds ratio with 95% confidence intervals). The secondary outcomes were the days of delirium, all‐cause mortality, and all‐cause discontinuation. Of 187 potentially eligible studies identified, 8 placebo‐controlled randomized controlled trials (n = 587) were included. This updated meta‐analysis showed that ramelteon was associated with lower odds of delirium occurrence than placebo (0.50; 0.29−0.86; I2 = 17.48%). In trial sequential analysis, the effect of ramelteon across the superiority boundary when using a relative risk reduction threshold ranging from 40% to 60%. In subgroup analyses, ramelteon compared with placebo was associated with lower odds of delirium occurrence in the elderly group (k = 5; 0.28; 0.09−0.85; I2 = 27.93%) and multiple dosage group (k = 5; 0.34; 0.14−0.82; I2 = 44.24%) but not in the non‐elderly and non‐multiple dosage groups. When considering surgical patients and medical patients separately, ramelteon showed a trend in the treatment of delirium prevention in both groups, while these findings were not statistically significant. No significant between‐group differences were found in the secondary outcomes. The current meta‐analysis provides updated and reliable evidence that ramelteon, in comparison with placebo, reduces the risk of delirium among hospitalized patients.
Heterogenity of planetesimal collisional plume probed by glass inclusions in metal globules of Sierra Gorda 013, an unusual CBa‐like chondrite
Authors: Lorenz C. A. , Ivanova M. A. , Zinovieva N. G. , Ryazantsev K. M. , Korochantsev A. V. 
Published: February 2023

AbstractMetal‐rich carbonaceous CB chondrites are generally assumed to be materials accreted from the gas–dust plume formed in catastrophic collisions of planetesimals, at least one of which was differentiated into a metal core and silicate shell. Micron‐sized inclusions of siliceous alkali‐rich glasses associated with sulfides were found in the metal globules of the Sierra Gorda 013 (SG 013), a CBa‐like chondrite. These inclusions are unusual carriers of volatile alkalis which are commonly depleted in CB chondrites. The inclusions are presented by two types: (1) Al‐bearing Nb‐poor glass associated with daubréelite and (2) Nb‐bearing Ca,Al,Mg‐poor glass associated with an unknown Na‐bearing Cr‐sulfide. The glass compositions do not correspond to equilibrium condensation, evaporation, or melting. The Nb‐bearing glass has a superchondritic Nb/Ta ratio (31) most likely indicating the fractionation of Nb and Ta in the high‐temperature gas–dust impact plume due to condensation from vapor or evaporation of precursor Nb‐rich particles. The glasses are interpreted as reaction products between refractory plume condensate particles (or possibly planetary or chondritic solids) with relatively low‐temperature K‐Na‐Si‐rich gas in oxidized conditions, possibly in a common plume vapor reservoir. Compositional differences indicate that the glasses and sulfides originated from several different sources under different fO2, fS2, andTconditions and were likely combined together and transported to the metal globule formation region by material flows in the heterogeneous impact plume. The glass–sulfide particles were enclosed in the globules aggregated from smaller solid or molten metal grains. The metal globules were further melted during transport to the high‐temperature plume region or by plume shockwave heating. Thus, the composition of the glasses, the host metal, and the main mass of SG 013 shows dynamic heterogeneity of physical conditions and impact plume composition after a large‐scale planetesimal collision.
Phylogenetic patterns of bioactive secondary metabolites produced by fungal endosymbionts in morning glories (Ipomoeeae, Convolvulaceae)
Authors: Quach Quynh N. , Clay Keith , Lee Stephen T. , Gardner Dale R. , Cook Daniel 
Published: February 2023

SummaryHeritable fungal endosymbiosis is underinvestigated in plant biology and documented in only three plant families (Convolvulaceae, Fabaceae, and Poaceae). An estimated 40% of morning glory species in the tribe Ipomoeeae (Convolvulaceae) have associations with one of two distinct heritable, endosymbiotic fungi (Periglandula and Chaetothyriales) that produce the bioactive metabolites ergot alkaloids, indole diterpene alkaloids, and swainsonine, which have been of interest for their toxic effects on animals and potential medical applications. Here, we report the occurrence of ergot alkaloids, indole diterpene alkaloids, and swainsonine in the Convolvulaceae; and the fungi that produce them based on synthesis of previous studies and new indole diterpene alkaloid data from 27 additional species in a phylogenetic, geographic, and life‐history context. We find that individual morning glory species host no more than one metabolite‐producing fungal endosymbiont (with one possible exception), possibly due to costs to the host and overlapping functions of the alkaloids. The symbiotic morning glory lineages occur in distinct phylogenetic clades, and host species have significantly larger seed size than nonsymbiotic species. The distinct and widely distributed endosymbiotic relationships in the morning glory family and their alkaloids provide an accessible study system for understanding heritable plant–fungal symbiosis evolution and their potential functions for host plants.
Developing eminence in STEMM: An interview study with talent development and STEMM experts
Authors: Luo Linlin , Stoeger Heidrun 
Published: February 2023

AbstractIn the present day, we need outstanding scientists, engineers, mathematicians, and medical science researchers more than ever to solve the world's most pressing issues, such as climate change, water contamination, and cyber security. Naturally, we ask the question: What does it take to develop eminence in science, technology, engineering, mathematics, and medical science (STEMM)? To answer this question, we interviewed two relevant groups of experts: 14 talent development researchers and 14 STEMM experts. The interview questions were developed based on the theoretical framework of the Actiotope Model of Giftedness and the related educational and learning capital approach that differentiates five types of exogenous resources (educational capital) and five types of endogenous resources (learning capital) that feed into talent development toward eminence. The results show that all types of capital were regarded as important by the experts for developing eminence in STEMM. However, there were also differences. We describe the educational and learning capital that talent development researchers and STEMM experts considered to be important for talent development in STEMM, as well as the similarities and differences between the two groups.