bluuebunny/crossref_metadata_2025_split huggingface dataset:
New seed coating containing Trichoderma viride with anti-pathogenic properties
Authors: Turkan Sena , Mierek-Adamska Agnieszka , Kulasek Milena , Konieczna Wiktoria B. , Dąbrowska Grażyna B. 
Published: June 2023

Background
To ensure food security in the face of climate change and the growing world population, multi-pronged measures should be taken. One promising approach uses plant growth-promoting fungi (PGPF), such as Trichoderma, to reduce the usage of agrochemicals and increase plant yield, stress tolerance, and nutritional value. However, large-scale applications of PGPF have been hampered by several constraints, and, consequently, usage on a large scale is still limited. Seed coating, a process that consists of covering seeds with low quantities of exogenous materials, is gaining attention as an efficient and feasible delivery system for PGPF.

Methods
We have designed a new seed coating composed of chitin, methylcellulose, and Trichoderma viride spores and assessed its effect on canola (Brassica napus L.) growth and development. For this purpose, we analyzed the antifungal activity of T. viride against common canola pathogenic fungi (Botrytis cinerea, Fusarium culmorum, and Colletotrichum sp.). Moreover, the effect of seed coating on germination ratio and seedling growth was evaluated. To verify the effect of seed coating on plant metabolism, we determined superoxide dismutase (SOD) activity and expression of the stress-related RSH (RelA/SpoT homologs).

Results
Our results showed that the T. viride strains used for seed coating significantly restricted the growth of all three pathogens, especially F. culmorum, for which the growth was inhibited by over 40%. Additionally, the new seed coating did not negatively affect the ability of the seeds to complete germination, increased seedling growth, and did not induce the plant stress response. To summarize, we have successfully developed a cost-effective and environmentally responsible seed coating, which will also be easy to exploit on an industrial scale.
Integrating robotics into wildlife conservation: testing improvements to predator deterrents through movement
Authors: Breck Stewart W. , Schultz Jeffrey T. , Prause David , Krebs Cameron , Giordano Anthony J. , Boots Byron 
Published: June 2023

Background
Agricultural and pastoral landscapes can provide important habitat for wildlife conservation, but sharing these landscapes with wildlife can create conflict that is costly and requires managing. Livestock predation is a good example of the challenges involving coexistence with wildlife across shared landscapes. Integrating new technology into agricultural practices could help minimize human-wildlife conflict. In this study, we used concepts from the fields of robotics (i.e., automated movement and adaptiveness) and agricultural practices (i.e., managing livestock risk to predation) to explore how integration of these concepts could aid the development of more effective predator deterrents.

Methods
We used a colony of captive coyotes as a model system, and simulated predation events with meat baits inside and outside of protected zones. Inside the protected zones we used a remote-controlled vehicle with a state-of-the art, commercially available predator deterrent (i.e., Foxlight) mounted on the top and used this to test three treatments: (1) light only (i.e., without movement or adaptiveness), (2) predetermined movement (i.e., with movement and without adaptiveness), and (3) adaptive movement (i.e., with both movement and adaptiveness). We measured the time it took for coyotes to eat the baits and analyzed the data with a time-to-event survival strategy.

Results
Survival of baits was consistently higher inside the protected zone, and the three movement treatments incrementally increased survival time over baseline except for the light only treatment in the nonprotected zone. Incorporating predetermined movement essentially doubled the efficacy of the light only treatment both inside and outside the protected zone. Incorporating adaptive movement exponentially increased survival time both inside and outside the protected zone. Our findings provide compelling evidence that incorporating existing robotics capabilities (predetermined and adaptive movement) could greatly enhance protection of agricultural resources and aid in the development of nonlethal tools for managing wildlife. Our findings also demonstrate the importance of marrying agricultural practices (e.g., spatial management of livestock at night) with new technology to improve the efficacy of wildlife deterrents.
Assessment of Risk Factors for Primary Open-angle Glaucoma
Authors: Mhadi Mohcine El , Ouafi Aziz El 
Published: June 2023

Introduction: primary open-angle glaucoma (POAG) is a chronic and progressive anterior optic neuropathy characterized by perimetric alterations and pathological excavation of the optic disc in the absence of other ocular pathologies or congenital anomalies. It is usually accompanied by an increase in intraocular pressure. Gonioscopic examination confirms that the iridocorneal angle is open. The term "risk factor" is defined as a condition statistically leading to an increased risk of occurrence of an event. The purpose of our work is to list the main risk factors of POAG.
Patients and Methods: This is a retrospective study carried out in our ophthalmology department over a period of 4 years between January 2018 and December 2021, involving one hundred patients with POAG followed in glaucoma consultation.
Results: These are 100 cases, with an average age of 64.27, with a male predominance. The most found risk factors in our series are: age, intraocular hypertension (IOH), thin cornea, arterial hypertension, diabetes and family history of glaucoma.
Conclusion: The identification of the main risk factors of POAG at the individual level is a major data of the management. Knowing these factors helps to monitor patients at risk more carefully and to adjust the treatment more appropriately in patients likely to develop glaucoma or to aggravate already known glaucoma. More efforts are required for early screening and education on POAG in communities, especially in a POAG high-risk population.
Disclosing the Intra‐Catalyst Non‐Covalent Interactions in Tetrahydropyran‐Based Dipeptidic Catalysts
Authors: García‐Monzón Irma , Borges‐González Jorge , Morales Ezequiel Q. , Fernández Israel , Martín Tomás 
Published: January 2025

AbstractHerein, we describe how minor structural modifications to our bifunctional organocatalysts based on sugar amino acids (SAAs) can alter the network of non‐covalent interactions (NCIs) within the catalyst, leading to significant changes in their catalytic activity. This is attributed to the intra‐catalyst NCIs, which induce conformational changes that are reflected in the transition state of the rate‐determining step of the Michael addition of aldehydes to trans‐β‐nitrostyrenes. Through kinetic experiments, conformational analysis, and DFT calculations, we found that the presence of a methoxy group at the C4 position of the tetrahydropyran ring reduces the catalytic activity by a factor of five compared to the catalyst without the methoxy group. Additionally, we have identified the different intra‐catalyst NCIs, both attractive and repulsive, that drive the conformational changes, ultimately modifying the energy levels of the transition states of the rate‐ and enantioselectivity‐determining step of the reaction.
A brief history of remote sensing of soybean
Authors: Prince Czarnecki Joby M. , Samiappan Sathishkumar , Bheemanahalli Raju , Huang Yanbo , Shammi Sadia Alam 
Published: January 2025

AbstractThe last 20 years have been a period of significant advancement in the tools available for remote sensing of soybean [Glycine max (L.) Merr.] in terms of price, ease of use, quality of information provided, and range of available research applications. This review article posits that now is an appropriate time to reflect on the previous two decades of research effort devoted to remote sensing of soybean to gain an appreciation for how far the field has come, while also acknowledging how much work remains to be performed. Structured by field management activities, this review is based on selected works culled from a broad search. These works contributed meaningful knowledge specific to soybean or elucidated key points not presented in those more intentionally focused on soybean. While there were many successes in the varied applications of remote sensing in soybean research, taking this 20‐year perspective also exposed areas of unmet expectations. Advances in knowledge are hampered by systemic challenges with inconsistent results and confounding factors imposed by research settings. There is potential to address these challenges by tempering expectations for what is possible and addressing reporting standards and data needs, specifically related to machine learning. The future is bright, but a concerted community effort is needed to continue to advance the state of knowledge into the next 20 years.
Hydrostability of Boroxines
Authors: Ono Kosuke 
Published: January 2025

AbstractBoroxines, six‐membered heterocyclic compounds with alternating O and B atoms, are readily formed by dehydration of boronic acids, while it is also known to be readily hydrolyzed to boronic acids under wet conditions. Therefore, hydrolysis is one of major problems for boroxine‐based architectures and materials, although they have self‐healing properties that can be restored simply by dehydration. In recent years, interesting studies have been reported to improve the hydrostability of boroxines, with some boroxines being stable even in water. This review categorizes and summarizes the findings on the enhancement of the hydrostability of boroxines according to the methods used.
How do Indigenous students and their families define success in education? Reporting on the results of Indigenous‐led qualitative interviews and participatory diagramming
Authors: Hughes Jarrod , Turnbull Claudia , Li Scarlett , King Jesse , Smith Leila 
Published: January 2025

AbstractIndigenous education has long been considered a critical area to the fulfilment of Indigenous rights and the rectification of Indigenous socioeconomic exclusion. Several approaches have been adopted to try and lift Indigenous education outcomes, most of which have failed to reach their intended targets. These approaches have occurred with limited Indigenous control and have consistently fallen short in measuring what matters to Indigenous students and families. Little research has been conducted on how Indigenous students and their families in Australia define educational success, particularly within the urban context. If Indigenous education outcomes are to improve, policy needs to reflect the aspirations and values of Indigenous students and families. Underpinned by an Indigenous Research Methodology, this paper explores how Indigenous students and their parents/carers define educational success. It finds that definitions vary in significant ways to policy definitions. While educational success is typically indicated by narrow measures of attendance, academic achievement and Year 12 completion in policy, definitions of educational success of the Indigenous participants in this research is far broader. The findings of this paper suggest that policymakers need to look beyond the narrow targets currently used to measure educational success if outcomes for Indigenous students are to improve.
Insights into LATE from postmortem imaging
Authors: Yushkevich Paul A. , Denning Amanda E , Levorse Lisa M , Ittyerah Ranjit , Sadeghpour Niyousha , Robinson John L. , Arezoumandan Sanaz , Ravikumar Sadhana , Ohm Daniel T , Schuck Theresa , Irwin David J , Lee Eddie B , Bahena Alejandra , Trotman Winifred , Das Sandhitsu R. , Wolk David A , Wisse Laura E.M. , de Flores Robin , Insausti Ricardo , Khandelwal Pulkit , Athalye Chinmayee 
Published: January 2025

AbstractBackgroundLimbic‐predominant age‐related TDP‐43 encephalopathy (LATE) is a neurodegenerative disease that is often comorbid with Alzheimer's disease (AD) and for which there are no reliable specific chemical or PET biomarkers available. Recent progress in disease‐modifying treatments for AD elevates the need for reliable in vivo detection of LATE and other comorbid neurodegenerative diseases. The promise of postmortem and antemortem MRI studies in LATE is that they will lead to the discovery of patterns of neurodegeneration associated with TDP‐43 pathology that could be reliably detected in vivo and used as a biomarker of LATE.MethodSeveral groups, including ours, have imaged brain tissue (e.g., whole hemisphere, or intact temporal lobe) from autopsies conducted in older adults with and without cognitive impairment. Specimens were imaged using high‐field, high‐resolution magnetic resonance imaging (MRI) and quantitative maps of cortical thickness were derived. Statistical associations between these structural measures and either computationally derived quantitative or expert‐assigned semi‐quantitative markers of TDP‐43 and tau pathology are computed as statistical parametric maps and statistically thresholded to identify clusters of significant associations. Alternatively, such associations can be derived from antemortem imaging studies, where MRI is performed in living individuals and linked to postmortem pathology measures.ResultBoth TDP‐43 and tau pathology are linked to cortical thinning in the medial temporal lobe, as revealed by postmortem and antemortem studies. Patterns of thinning associated with each pathology are distinct yet overlapping, and sensitive to cohort selection, choice of pathology measure, and other factors.ConclusionReliable in vivo detection of TDP‐43 based on in vivo MRI signatures is likely possible but requires effort from the community to pool scarce ex vivo imaging and pathology datasets, standardization of quantitative pathology and MRI measures, and extensive validation.
A cluster randomized trial: Exploratory quantitative analysis comparing resident outcomes for two approaches to promote non‐pharmacological, resident‐centered dementia care in nursing homes
Authors: Shier Victoria , Bae‐Shaaw Yuna H. , Sood Neeraj , Chew Felicia M , Piersol Catherine V , Lekovitch Cara A. , Como Dominique H. , Wong Carin M. , Morris Mike , Leland Natalie E 
Published: January 2025

AbstractBackgroundResident advocates and national nursing home dementia care initiatives have prioritized non‐pharmacological approaches to manage behavioral and psychological symptoms of Alzheimer’s Disease and related dementias. Evidence supports both team‐ and problem‐based approaches to non‐pharmacological dementia care, but the comparative effectiveness of these two approaches has not been examined.MethodWe implemented a cluster randomized controlled trial in 53 nursing homes ot compare the team‐based and problem‐based approaches to dementia care. Nursing homes in the team‐based approach arm completed a five‐module facility‐wide training, which provided a common language and shared knowledge across all staff. The problem‐based approach engaged in discipline‐specific web‐based training. Resident assessment data from the Minimum Data Set 3.0 was analyzed. Primary outcomes were antipsychotic medication use, behavioral symptoms, rejection of care, and wandering. Secondary outcomes were unintentional weight loss, falls, depression and restraint use. We compared change in outcomes from the six months baseline period to six months follow‐up period across study arms using a difference‐in‐differences model.ResultThe percentage of residents with wandering increased 3.51 percentage points (p = 0.02) in the team‐based approach arm compared to the problem‐based approach arm, with no evidence of associated adverse events (e.g., falls, unintentional weight loss). There was no statistically significant difference in antipsychotic medication use or other resident outcomes across arms. However, the reduction in rejection of care and the increase in behavioral symptoms in the team‐based approach compared to the problem‐based approach were potentially clinically meaningful differences between the two arms.ConclusionResults suggest a benefit for resident wandering in the team‐based approach. While findings are exploratory, training for all nursing home staff that accounts for diverse education and training needs may influence care delivery and have benefits for residents with dementia.
Fostering the delivery of non‐pharmacological nursing home dementia care: Designing and executing a multi‐site pragmatic clinical trial
Authors: Leland Natalie E , Shier Victoria , Lekovitch Cara A. , Bae‐Shaaw Yuna H. , Sood Neeraj , Day Claire E , Cass Paul , Como Dominique H. , Wong Carin M. , Chew Felicia M 
Published: January 2025

AbstractBackgroundNursing home (NH) staff face daily challenges caring for the residents living with dementia (e.g., management of behavioral and psychological symptoms). Research supports the delivery of team‐ and problem‐based non‐pharmacological approaches to dementia care. The team‐based approach includes dementia training for all NH staff using a common language and strategies to support continuity and sustainability. The problem‐based approach capitalizes on the discipline‐specific expertise of the professional healthcare providers (e.g., rehabilitation) to target emergent issues. Prior work has not compared the two approaches. Our objective is to determine if there is a difference between these non‐pharmacological dementia care approaches with respect to resident outcomes and satisfaction and acceptability among NH staff and family caregivers.MethodWe will describe the development and execution of a community‐engaged pragmatic clinical trial that compared team‐ and problem‐based approaches to NH dementia care. The trial leveraged a convergent mixed methods design in order to examine (a) comparative effectiveness of two dementia care approaches on long‐term NH resident outcomes (e.g., off‐label antipsychotic medications), (b) whether either approach was protective against the negative consequences of COVID‐19, and (c) NH staff and family caregiver perspectives of the care approaches (e.g., application, recommendations, sustainability). Data collection included the NH Minimum Data Set, electronic medical records, and interviews with NH staff and families of residents living with dementia.Result80 NHs were randomized to one of the two treatment approaches. This presentation will share considerations for designing and implementing pragmatic trials in a United States NH context. Designing this NH pragmatic trial required a multi‐level implementation framework, which accounted for variations in societal, contextual, and encounter level factors related to the approaches as well as peripheral factors impacting NH care more broadly. Successful completion of the study required the active engagement of a community‐engaged Advisory Committee.ConclusionThe design and execution of NH implementation research should consider intervention‐specific and peripheral factors spanning levels of influence and be anchored in community‐engagement methodology. Results of the trial can provide health system leaders and policymakers with evidence on how to advance dementia care in an effort to optimize resident outcomes.
Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI
Authors: Liou Jr‐Jiun , Li Jinghang , Berardinelli Jacob , Jin Hecheng , Santini Tales , Noh Jaehoon , Farhat Nadim , Aizenstein Howard J , Yong William , Head Elizabeth , Ikonomovic Milos D , Ibrahim Tamer S , Kofler Julia 
Published: January 2025

AbstractBackgroundHigh‐resolution and high‐contrast postmortem MRI can unveil structural abnormalities overlooked by antemortem MRI, making it well‐suited for targeted pathology assessments. In community cohorts, limbic‐predominant age‐related TDP‐43 encephalopathy (LATE) pathology is linked with smaller amygdala [Makkinejad 2019 Neurobiol Aging] and hippocampal volumes [Josephs 2015 Ann Neurol]. Whether a similar association exists in Down syndrome (DS) remains unexplored. This study investigates the potential correlation of amygdala and hippocampal atrophy with AD and LATE pathology in both DS and AD.Methods7T postmortem ex vivo MRI scans (n=67, comprising 13 DS and 54 AD) and a subset of antemortem MRI scans (n=17) were obtained. Manual segmentation of the hippocampus and amygdala was performed. The resulting volumes, normalized to fresh brain weight and adjusted for age, sex, and ApoE4, were correlated with pathological findings, including Thal phase, Braak stage, LATE stage, and the presence of hippocampal sclerosis (HS).ResultsPostmortem‐antemortem volume correlation was significant for the hippocampus (p=0.0066) but not the amygdala. Compared to AD, individuals with DS had significantly lower hippocampal (p=0.0004) and amygdala (p=0.0002) volumes. In the DS group, lower hippocampal (p=0.0051) and amygdala (p=0.0127) volumes correlated with more severe Braak stage, with no significant correlations with Thal phase. In two DS cases that exhibited LATE or HS, trends toward smaller hippocampal volume were observed. In AD, lower hippocampal volume correlated with more severe Thal phase (p=0.0020), Braak stage (p=0.0081), LATE stage (p=0.0017), and the presence of HS (p<0.0001), whereas lower amygdala volume correlated with more severe LATE stage (p=0.0160) and HS (p=0.0139) but not with Thal phase or Braak stage.Conclusions7T postmortem MRI protocol produced good alignment of postmortem volumes with antemortem findings and revealed correlations between volume measures and neuropathological burden. In AD, hippocampal volume is influenced by both AD and LATE pathologies, whereas amygdala volume appears to be influenced primarily by LATE. In DS, hippocampal volume is smaller than in AD and primarily influenced by tau pathology. Future investigation will also explore Lewy body pathology and its potential association with hippocampal and amygdala volume changes in DS and AD.