bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gait optimization and energy-based stability for biped locomotion using large-scale programming
Authors: Xie Ye , Gao Chengzhi , Zhu Shiqiang , Yan Xufei , Kong Lingyu , Xie Anhuan , Gu Jason , Zhang Dan 
Published: April 2023

AbstractThis paper presents a gait optimization method to generate the locomotion pattern for biped and discuss its stability. The main contribution of this paper is a newly proposed energy-based stability criterion, which permits the dynamic stable walking and could be straight-forwardly generalized to different locomotion scenarios and biped robots. The gait optimization problem is formulated subject to the constraints of the whole-body dynamics and kinematics. The constraints are established based on the modelling of bipedal hybrid dynamical systems. Following the whole-body modelling, the system energy is acquired and then applied to create the stability criterion. The optimization objective is also established on the system energy. The gait optimization is solved by being converted to a large-scale programming problem, where the transcription accuracy is improved via the spectral method. To further reduce the dimensionality of the large-scale problem, the whole-body dynamics is re-constructed. The generalization of the optimized gait is improved by the design of feedback control. The optimization examples demonstrate that the stability criterion naturally leads to a cyclic biped locomotion, though the periodicity was not previously imposed. Two simulation cases, level ground walking and slope walking, verify the generalization of the stability criterion and feedback control. The stability analyses are carried out by investigating the motions of centre of gravity and centre of pressure. It is revealed that if the tracked speed is above 0.3 m/s or the biped accelerates/climbs the slope, the stability criterion accomplishes the dynamic stable walking, where zero moment point criterion is not strictly complied.
Aspirations and limitations: the state of world music education in secondary schools in multicultural Manchester
Authors: Nissen James 
Published: April 2023

AbstractThis article examines the state of world music education in secondary schools in Manchester, analysing school curricula and exam specifications alongside interviews conducted with teachers. World music occupies a significant position in music education at Key Stage 3, but its scope becomes progressively limited at higher levels. While teachers recognise the benefits of world music education for promoting cultural understanding and social inclusion, they struggle to maintain it throughout their programmes because of barriers related to examinations, teaching materials and school resources. This creates a dysfunctional learning trajectory that discourages students from studying music, particularly disadvantaging those from weaker socio-economic backgrounds. Nevertheless, teachers’ perspectives, often overshadowed by government policy, evidence strong aspirations to implement multicultural music education in practice.
Relatively hyperbolic groups with strongly shortcut parabolics are strongly shortcut
Authors: HODA NIMA , KRISHNA M S SURAJ 
Published: April 2023

AbstractWe show that a group that is hyperbolic relative to strongly shortcut groups is itself strongly shortcut, thus obtaining new examples of strongly shortcut groups. The proof relies on a result of independent interest: we show that every relatively hyperbolic group acts properly and cocompactly on a graph in which the parabolic subgroups act properly and cocompactly on convex subgraphs.
Assessment of cell-free DNA and apoptosis in an oocyte microenvironment: promising biomarkers to predict intracytoplasmic sperm injection outcomes
Authors: Debbarh Hasnae , Jamil Malak , Jelloul Hasnae , Zakaria Achraf , Louanjli Noureddine , Cadi Rachida 
Published: April 2023

SummaryCell-free DNA (cf-DNA) is defined as DNA fragments that are released into the body fluids from apoptosis or necrosis cells, including follicular fluid (FF), which can affect the microenvironment of the oocyte associated with infertility. We aimed to investigate a relationship between apoptosis of cumulus cells (CCs) and cf-DNA levels in FF and clinical outcomes of women undergoing intracytoplasmic sperm injection (ICSI). Therefore, 82 FF samples were collected, and the corresponding CCs were isolated for ICSI procedures. FF cf-DNA concentration was quantified using ALU-quantitative polymerase chain reaction (PCR), and CCs DNA fragmentation index (DFI) was evaluated by the terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labelling (TUNEL) method. We found that cf-DNA and DFI levels were significantly higher in FF and CCs samples related to the age of women ≥37 years compared with the age of women < 37 years. Moreover, in older and younger women, FF cf-DNA and CCs DFI levels were significantly lower when the anti-Müllerian hormone (AMH) level was > 1.1 ng/ml compared with when AMH ≤ 1.1 ng/ml. In addition, patients with a low number of retrieved oocytes ≤ 6 had significantly higher levels of CCs DFI and FF cf-DNA than women with a higher number of retrieved oocytes > 6. Additionally, we observed that higher levels of cf-DNA and DFI were associated with poor oocyte maturity and poor embryo quality. Finally, cf-DNA and DFI levels were significantly lower in pregnant women than in non-pregnant ones. We conclude that DFI and cf-DNA levels in the oocyte microenvironment could have potential use in evaluating oocyte and embryo developmental competence.
Solving Rehabilitation Scheduling Problems via a Two-Phase ASP Approach
Authors: CARDELLINI MATTEO , DE NARDI PAOLO , DODARO CARMINE , GALATÀ GIUSEPPE , GIARDINI ANNA , MARATEA MARCO , PORRO IVAN 
Published: April 2023

AbstractA core part of the rehabilitation scheduling process consists of planning rehabilitation physiotherapy sessions for patients, by assigning proper operators to them in a certain time slot of a given day, taking into account several legal, medical, and ethical requirements and optimizations, for example, patient’s preferences and operator’s work balancing. Being able to efficiently solve such problem is of upmost importance, in particular after the COVID-19 pandemic that significantly increased rehabilitation’s needs. In this paper, we present a two-phase solution to rehabilitation scheduling based on Answer Set Programming, which proved to be an effective tool for solving practical scheduling problems. We first present a general encoding and then add domain-specific optimizations. Results of experiments performed on both synthetic and real benchmarks, the latter provided by ICS Maugeri, show the effectiveness of our solution as well as the impact of our domain-specific optimizations.
Characterization of Western Himalayan small-seeded red beans (Phaseolus vulgaris L.) for yield, quality and resilience
Authors: Sofi Parvaze A , Shafi Sadiah , Fatima Samreen , Rani Sujeela , Ahmad Rayees , Banoo Aqleema , Gani Saima , Zargar Sajad Majeed , Padder B. A. , Zaffar Aaqif , Nabi Asha , Jha Prakash 
Published: April 2023

AbstractWestern Himalayan region is a rich repository of common bean genetic resources evolved over generations of farmer selection. The bean variability encompasses various use categories such as dry, snap and shelled beans. The present study aimed to characterize 40 small-seeded red common bean genotypes collected from different districts of Kashmir valley as well as Poonch, Rajouri and Bhaderwah areas of Jammu which are world famous for their beans. Based on 5-year evaluation, there was substantial variability for various qualitative traits as well as quantitative traits. Among variability parameters, higher PCV and GCV values were recorded for plant height, seed yield per plant and number of pods per plant and low for days to maturity, seed length and pod length. High heritability was recorded for all the traits ranging from 78.72 to 94.87%. There was substantial variability in root traits scored in laboratory and greenhouse as well as canopy temperature depression and relative water content. Various genotypes were found resistant to bean common mosaic virus (WB-N-1, WB-N-11, WB-1318, WB-401, WB-451, WB-1634); anthracnose (WB-1634 WB-83, WB-258, WB-1282, WB-1304); angular leaf spot (WB-6, WB-1634, WB-258, WB-451, N-1 and N-10); Fusarium wilt (WB-341, WB-451, WB-N-1 and WB-1587) and Ascochyta blight (WB-6). Similarly WB-92 was highly resistant to shattering. The genotypes WB-341, WB-1634, WB-N-1 performed better under water stress, WB-N-1 and WB-1634 were resistant to multiple diseases and WB-1634 had better cooking quality. The genotypes identified can be used in bean improvement programmes and have also been submitted to NBPGR for long-term storage.
Producers marketing a novel crop: a field-level view of hemp market channels
Authors: Hill Rebecca , Jablonski Becca B.R. , Van Laney , Wang Ming , Patalee Buddhika , Shepherd Jonathan , LeRoux Matt , Mark Tyler , Mooney Daniel F. , Thilmany Dawn 
Published: April 2023

Abstract
We assess emerging relationships between production decisions and market channel selection among a small sample of hemp growers (22) in Colorado and Kentucky using qualitative interviews. We found producers differences by market channel, product and state. For instance, producers who relied on intermediated marketing strategies cultivated more acres on average and used fewer distinct market channels and strategies than those relying on direct markets. Product differences were found regarding processing, storage and perishability. Respondents identified four factors critical to their choice of market channels for their hemp products: research, profitability, trust and knowledge. The findings can help inform public and private decision-making regarding best hemp marketing practices and future needs of the hemp industry.
Interseismic Coupling, Asperity Distribution, and Earthquake Potential on Major Faults in Southeastern Tibet
Authors: Li Yanchuan , Shan Xinjian , Gao Zhiyu , Huang Xing 
Published: April 2023

AbstractSoutheastern (SE) Tibet is one of the most seismically active regions in mainland China, but the spatial distribution of interseismic coupling that quantifies seismic hazard is unknown along most major faults. In this study, we constructed an elastic block model to invert Global Positioning System data for slip rates and locking coefficients along 20 major faults in SE Tibet. Our results identify 27 strongly coupled fault segments with locking coefficients >0.5, defined as potential seismogenic asperities, extending laterally for 36–330 km. Quantitative calculations of seismic moment budgets on these seismogenic asperities indicate that they are capable of generating Mw 6.4–7.7 earthquakes in the next few decades, of which the Anninghe, Daliangshan and Red River faults have the potential for Mw ≥ 7.5 earthquakes. The interseismic coupling model provides a component for probabilistic analysis of future seismic hazards in densely populated Southwest China.
The Distribution of Small‐Scale Irregularities in the E‐Region, and Its Tendency to Match the Spectrum of Field‐Aligned Current Structures in the F‐Region
Authors: Ivarsen Magnus F. , Lozinsky Adam , St‐Maurice Jean‐Pierre , Spicher Andres , Huyghebaert Devin , Hussey Glenn C. , Galeschuk Draven , Pitzel Brian , Vierinen Juha 
Published: April 2023

AbstractWe associate new data from icebear, a coherent scatter radar located in Saskatchewan, Canada, with scale‐dependent physics in the ionosphere. We subject the large‐scale icebear 3D echo patterns (treated as 2D point clouds) to a data analysis technique hitherto never applied to the ionosphere, a technique that is widely applied in cosmological red‐shift surveys to characterize the spatial clustering of galaxies. The technique results in a novel method to calculate the spatial power spectral density of the greater ionospheric irregularity field. We compare results from this method to in‐situ plasma density and magnetic field observations from the Swarm mission. We show that there is a remarkable similarity between echo clustering spectra in the E‐region and the field‐aligned current structuring spectrum observed in the F‐region: a clear and characteristic preferred scale (5 km) both in the E‐ and F‐region spectra. We discuss the possibility that this represents evidence of an energy injection into the ionospheric irregularity field via energetic particle precipitation, but offer alternative interpretations with wider connotations for the ionosphere‐magnetosphere system. These findings open new and promising avenues of research for the study of the location of ionospheric scatter echoes with 3D information. It constitutes a novel way to consider the pattern of ionospheric irregularities over wide fields of view when there is an abundance of radar echoes, which allows for the analysis of radar data as point clouds.
A 0.82 μVrms ultralow 1/f noise bandgap reference for a MEMS gyroscope
Authors: Zou Junjun , Wei Qi , Ju Chunge , Liao Hua , Gu Haoyu , Xing Bowen , Zhou Bin , Zhang Rong 
Published: April 2023

AbstractHigh-precision microelectromechanical system (MEMS) gyroscopes are significant in many applications. Bias instability (BI) is an important parameter that indicates the performance of a MEMS gyroscope and is affected by the 1/f noise of the MEMS resonator and readout circuit. Since the bandgap reference (BGR) is an important block in the readout circuit, reducing its 1/f noise is key to improving a gyroscope’s BI. In a traditional BGR, the error amplifier is applied to provide a virtual short-circuit point, but it introduces the main low-frequency noise sources. This paper proposes an ultralow 1/f noise BGR by removing the error amplifier and applying an optimized circuit topology. In addition, a simplified but accurate noise model of the proposed BGR is obtained to optimize the BGR’s output noise performance. To verify this design, the proposed BGR has been implemented in a 180 nm CMOS process with a chip area of 545 × 423 μm. The experimental results show that the BGR’s output integrated noise from 0.1 to 10 Hz is 0.82 μV and the thermal noise is 35 nV/√Hz. Furthermore, bias stability tests of the MEMS gyroscope fabricated in our laboratory with the proposed BGR and some commercial BGRs are carried out. Statistical results show that reducing the BGR’s 1/f noise can nearly linearly improve the gyroscope’s BI.
Normal range and predictors of serum erythroferrone in infants
Authors: Bäckström Fredrik , Chmielewska Anna , Domellöf Magnus , Berglund Staffan K. 
Published: April 2023

Abstract
Background
Erythroferrone (ERFE) has been identified as a hepcidin-regulating hormone synthetized by erythroblasts correlating to the erythropoietic activity and the needs for iron substrate in bone marrow of adults. The present study aimed to assess the ERFE serum concentrations and its predictors in infants.

Methods
ERFE was explored at 4 time points during the first year of life in 45 healthy, breastfed, normal birth weight (NBW) infants, and 136 marginally low birth weight infants (LBW, 2000–2500 g) receiving iron (N = 58) or placebo (N = 78) between 6 weeks and 6 months of age.

Results
ERFE concentrations were low at birth, increasing gradually during the first year of life. In NBW infants, reference ranges (5th to 95th percentile) were at 6 weeks <0.005–0.99 ng/mL and at 12 months <0.005–33.7 ng/mL. ERFE was higher in LBW infants at 6 weeks but lower at 12 months compared to NBW and minimally affected by iron supplementation among LBW infants. Correlations of ERFE with erythropoietic and iron status markers were weak and inconsistent.

Conclusions
The role of ERFE in the crosstalk of erythropoiesis and iron homeostasis remains unclear in infants and further studies on ERFE in infants and older children are warranted within the framework of the erythropoietin–ERFE–hepcidin axis.

Impact

Normal range of erythroferrone in healthy infants is described for the first time.

Erythroferrone in infants lacks correlation to iron status and markers of erythropoiesis.

The findings indicate differences in infant regulation of iron homeostasis as compared to adults.

The findings point to a need to study infant erythropoiesis separately from its adult counterpart.

The findings may have clinical impact on management strategies of iron-loading anemia in infancy.
Unexplored diversity and ecological functions of transposable phages
Authors: Zhang Mujie , Hao Yali , Yi Yi , Liu Shunzhang , Sun Qingyang , Tan Xiaoli , Tang Shan , Xiao Xiang , Jian Huahua 
Published: April 2023

AbstractPhages are prevalent in diverse environments and play major ecological roles attributed to their tremendous diversity and abundance. Among these viruses, transposable phages (TBPs) are exceptional in terms of their unique lifestyle, especially their replicative transposition. Although several TBPs have been isolated and the life cycle of the representative phage Mu has been extensively studied, the diversity distribution and ecological functions of TBPs on the global scale remain unknown. Here, by mining TBPs from enormous microbial genomes and viromes, we established a TBP genome dataset (TBPGD), that expands the number of accessible TBP genomes 384-fold. TBPs are prevalent in diverse biomes and show great genetic diversity. Based on taxonomic evaluations, we propose the categorization of TBPs into four viral groups, including 11 candidate subfamilies. TBPs infect multiple bacterial phyla, and seem to infect a wider range of hosts than non-TBPs. Diverse auxiliary metabolic genes (AMGs) are identified in the TBP genomes, and genes related to glycoside hydrolases and pyrimidine deoxyribonucleotide biosynthesis are highly enriched. Finally, the influences of TBPs on their hosts are experimentally examined by using the marine bacterium Shewanella psychrophila WP2 and its infecting transposable phage SP2. Collectively, our findings greatly expand the genetic diversity of TBPs, and comprehensively reveal their potential influences in various ecosystems.
Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice
Authors: Everette Kelcee A. , Newby Gregory A. , Levine Rachel M. , Mayberry Kalin , Jang Yoonjeong , Mayuranathan Thiyagaraj , Nimmagadda Nikitha , Dempsey Erin , Li Yichao , Bhoopalan Senthil Velan , Liu Xiong , Davis Jessie R. , Nelson Andrew T. , Chen Peter J. , Sousa Alexander A. , Cheng Yong , Tisdale John F. , Weiss Mitchell J. , Yen Jonathan S. , Liu David R. 
Published: April 2023

AbstractSickle-cell disease (SCD) is caused by an A·T-to-T·A transversion mutation in the β-globin gene (HBB). Here we show that prime editing can correct the SCD allele (HBBS) to wild type (HBBA) at frequencies of 15%–41% in haematopoietic stem and progenitor cells (HSPCs) from patients with SCD. Seventeen weeks after transplantation into immunodeficient mice, prime-edited SCD HSPCs maintained HBBA levels and displayed engraftment frequencies, haematopoietic differentiation and lineage maturation similar to those of unedited HSPCs from healthy donors. An average of 42% of human erythroblasts and reticulocytes isolated 17 weeks after transplantation of prime-edited HSPCs from four SCD patient donors expressed HBBA, exceeding the levels predicted for therapeutic benefit. HSPC-derived erythrocytes carried less sickle haemoglobin, contained HBBA-derived adult haemoglobin at 28%–43% of normal levels and resisted hypoxia-induced sickling. Minimal off-target editing was detected at over 100 sites nominated experimentally via unbiased genome-wide analysis. Our findings support the feasibility of a one-time prime editing SCD treatment that corrects HBBS to HBBA, does not require any viral or non-viral DNA template and minimizes undesired consequences of DNA double-strand breaks.
The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice
Authors: Fan Yong , Støving René Klinkby , Berreira Ibraim Samar , Hyötyläinen Tuulia , Thirion Florence , Arora Tulika , Lyu Liwei , Stankevic Evelina , Hansen Tue Haldor , Déchelotte Pierre , Sinioja Tim , Ragnarsdottir Oddny , Pons Nicolas , Galleron Nathalie , Quinquis Benoît , Levenez Florence , Roume Hugo , Falony Gwen , Vieira-Silva Sara , Raes Jeroen , Clausen Loa , Telléus Gry Kjaersdam , Bäckhed Fredrik , Oresic Matej , Ehrlich S. Dusko , Pedersen Oluf 
Published: April 2023

AbstractAnorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are women and it has a population prevalence of about 1%, but evidence-based treatment is lacking. The pathogenesis of AN probably involves genetics and various environmental factors, and an altered gut microbiota has been observed in individuals with AN using amplicon sequencing and relatively small cohorts. Here we investigated whether a disrupted gut microbiota contributes to AN pathogenesis. Shotgun metagenomics and metabolomics were performed on faecal and serum samples, respectively, from a cohort of 77 females with AN and 70 healthy females. Multiple bacterial taxa (for example,Clostridiumspecies) were altered in AN and correlated with estimates of eating behaviour and mental health. The gut virome was also altered in AN including a reduction in viral–bacterial interactions. Bacterial functional modules associated with the degradation of neurotransmitters were enriched in AN and various structural variants in bacteria were linked to metabolic features of AN. Serum metabolomics revealed an increase in metabolites associated with reduced food intake (for example, indole-3-propionic acid). Causal inference analyses implied that serum bacterial metabolites are potentially mediating the impact of an altered gut microbiota on AN behaviour. Further, we performed faecal microbiota transplantation from AN cases to germ-free mice under energy-restricted feeding to mirror AN eating behaviour. We found that the reduced weight gain and induced hypothalamic and adipose tissue gene expression were related to aberrant energy metabolism and eating behaviour. Our ‘omics’ and mechanistic studies imply that a disruptive gut microbiome may contribute to AN pathogenesis.
Neurocognitive bases of self-monitoring of inner speech in hallucination prone individuals
Authors: Stephan-Otto Christian , Núñez Christian , Lombardini Federica , Cambra-Martí Maria Rosa , Ochoa Susana , Senior Carl , Brébion Gildas 
Published: April 2023

AbstractVerbal hallucinations in schizophrenia patients might be seen as internal verbal productions mistaken for perceptions as a result of over-salient inner speech and/or defective self-monitoring processes. Similar cognitive mechanisms might underpin verbal hallucination proneness in the general population. We investigated, in a non-clinical sample, the cerebral activity associated with verbal hallucinatory predisposition during false recognition of familiar words —assumed to stem from poor monitoring of inner speech—vs. uncommon words. Thirty-seven healthy participants underwent a verbal recognition task. High- and low-frequency words were presented outside the scanner. In the scanner, the participants were then required to recognize the target words among equivalent distractors. Results showed that verbal hallucination proneness was associated with higher rates of false recognition of high-frequency words. It was further associated with activation of language and decisional brain areas during false recognitions of low-, but not high-, frequency words, and with activation of a recollective brain area during correct recognitions of low-, but not high-, frequency words. The increased tendency to report familiar words as targets, along with a lack of activation of the language, recollective, and decisional brain areas necessary for their judgement, suggests failure in the self-monitoring of inner speech in verbal hallucination-prone individuals.