bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased parental effort fails to buffer the cascading effects of warmer seas on common guillemot demographic rates
Authors: Wanless Sarah , Albon Steve D. , Daunt Francis , Sarzo Blanca , Newell Mark A. , Gunn Carrie , Speakman John R. , Harris Michael P. 
Published: May 2023

Abstract

Climate warming can reduce food resources for animal populations. In species exhibiting parental care, parental effort is a ‘barometer’ of changes in environmental conditions. A key issue is the extent to which variation in parental effort can buffer demographic rates against environmental change.

Seabirds breed in large, dense colonies and globally are major predators of small fish that are often sensitive to ocean warming. We explored the causes and consequences of annual variation in parental effort as indicated by standardised checks of the proportions of chicks attended by both, one or neither parent, in a population of common guillemots Uria aalge over four decades during which there was marked variation in marine climate and chick diet. We predicted that, for parental effort to be an effective buffer, there would be a link between environmental conditions and parental effort, but not between parental effort and demographic rates.

Environmental conditions influenced multiple aspects of the prey delivered by parents to their chicks with prey species, length and energy density all influenced by spring sea surface temperature (sSST) in the current and/or previous year. Overall, the mean annual daily energy intake of chicks declined significantly when sSST in the current year was higher.

In accordance with our first prediction, we found that parental effort increased with sSST in the current and previous year. However, the increase was insufficient to maintain chick daily energy intake. In contrast to our second prediction, we found that increased parental effort had major demographic consequences such that growth rate and fledging success of chicks, and body mass and overwinter survival of breeding adults all decreased significantly.

Common guillemot parents were unable to compensate effectively for temperature‐mediated variation in feeding conditions through behavioural flexibility, resulting in immediate consequences for breeding population size because of lower adult survival and potentially longer‐term impacts on recruitment because of lower productivity. These findings highlight that a critical issue for species' responses to future climate change will be the extent to which behavioural buffering can offer resilience to deteriorating environmental conditions.
Why do Historians Ignore Digital Analysis? Bring on the Luddites
Authors: Blaxill Luke 
Published: May 2023

AbstractThis article argues that historians have failed to grasp the profound opportunities afforded by computational analysis. Despite the abundance of machine‐readable data liberated by digitisation—alongside tools and exemplar studies—there has been no widespread embrace of text mining or revival of cliometrics. This ambivalence has arisen mainly through apathy and side‐lining of computational analysis to a specialist methodological niche. The absence of justification is damaging to the intellectual vitality of the discipline and its capacity to face the dawning age of data science.The article calls for an urgent debate about the historian and the computer. More than anything else, this requires sceptics to come forward to meet the advocates to discuss how we face the future. British political history has a proud tradition of methodological innovation and there is no better subfield in which to begin a debate that has fundamental implications for the whole discipline.
Real‐world tolerance and outcomes of oxaliplatin‐based adjuvant chemotherapy for stage III colon cancer—Does dose intensity matter?
Authors: Yoon Robert , Wilkinson Kate , Gabriel Gabriel , Kadaan Nasreen , Roberts Tara , Lim Stephanie , Asghari Ray , Lee Cheok Soon , Chua Wei , Ng Weng 
Published: May 2023

AbstractIntroductionFluoropyrimidine and oxaliplatin‐based adjuvant chemotherapy delivered as 5‐fluorouracil, leucovorin and oxaliplatin (FOLFOX), or capecitabine and oxaliplatin (CAPOX) is the standard of care for resected stage III colon cancer. Without randomized trial data, we compared real‐world dose intensity, survival outcomes, and tolerability of these regimens.MethodsRecords of patients treated with FOLFOX or CAPOX in the adjuvant setting for stage III colon cancer across four institutions in Sydney during 2006–2016 were reviewed. The relative dose intensity (RDI) of fluoropyrimidine and oxaliplatin of each regimen, disease‐free survival (DFS), overall survival (OS), and incidence of grade ≥2 toxicities were compared.ResultsCharacteristics of patients receiving FOLFOX (n = 195) and CAPOX (n = 62) were evenly matched. FOLFOX patients had a higher mean RDI for both fluoropyrimidine (85% vs. 78%, p < 0.01) and oxaliplatin (72% vs. 66%, p = 0.06). In spite of a lower RDI, CAPOX patients trended toward a better 5‐year DFS (84% vs. 78%, HR = 0.53, p = 0.068) and similar OS (89% vs. 89%, HR = 0.53, p = 0.21) compared to the FOLFOX group. This difference was most pronounced in the high‐risk (T4 or N2) group where 5‐year DFS was 78% versus 67% (HR = 0.41, p = 0.042). Patients receiving CAPOX experienced more grade ≥2 diarrhea (p = 0.017) and hand‐foot syndrome (p < 0.001) but not peripheral neuropathy or myelosuppression.ConclusionIn a real‐world setting, patients who received CAPOX had similar OS rates when compared to those receiving FOLFOX in the adjuvant setting in spite of lower RDI. In the high‐risk population, CAPOX appears to demonstrate a superior 5‐year DFS over FOLFOX.
Prognostic impact of complex and/or monosomal karyotypes in post‐transplant poor cytogenetic acute myeloid leukaemia: A quantitative approach
Authors: Jo Tomoyasu , Arai Yasuyuki , Oshima Shinichiro , Kondo Tadakazu , Harada Kaito , Uchida Naoyuki , Doki Noriko , Fukuda Takahiro , Tanaka Masatsugu , Ozawa Yukiyasu , Kuriyama Takuro , Ikegame Kazuhiro , Katayama Yuta , Ota Shuichi , Ara Takahide , Kawakita Toshiro , Onizuka Makoto , Ichinohe Tatsuo , Atsuta Yoshiko , Yanada Masamitsu ,   the Japanese Society for Transplantation and Cellular Therapy (JSTCT)
Published: May 2023

SummaryTo evaluate the prognostic impact of complex karyotype (CK) and/or monosomal karyotype (MK) in combination with various clinical factors on allogeneic stem cell transplantation (HSCT) outcomes of patients with acute myeloid leukaemia (AML), we analysed the registry database of adult AML patients who underwent allogeneic HSCT between 2000 and 2019 in Japan. Among 16 094 patients, those with poor cytogenetic risk (N = 3345) showed poor overall survival (OS) after HSCT (25.3% at 5 years). Multivariate analyses revealed that CK and/or MK (hazard ratio [HR], 1.31 for CK without MK; 1.27 for MK without CK; and 1.73 for both), age at HSCT ≥50 years (HR, 1.58), male sex (HR, 1.40), performance status ≥2 (HR, 1.89), HCT‐CI score ≥3 (HR, 1.23), non‐remission status at HSCT (HR, 2.49), and time from diagnosis to HSCT ≥3 months (HR, 1.24) independently reduced post‐HSCT OS among patients with poor cytogenetic risk AML. A risk scoring system based on the multivariate analysis successfully stratified patients into five distinct groups for OS. This study confirms the negative effects of CK and MK on post‐HSCT outcomes, and offers a powerful risk scoring system for predicting prognoses after HSCT among AML patients with unfavourable cytogenetics.
Final results of a phase II study of CHOEP plus lenalidomide as initial therapy for patients with stage II–IV peripheral T‐cell lymphoma
Authors: Stuver Robert , Horwitz Steven M. , Advani Ranjana H. , Vose Julie M. , Lee Hun Ju , Mehta‐Shah Neha , Zain Jasmine M. , Haverkos Bradley , Lechowicz Mary Jo , Moskowitz Alison J. , Pham Luu Q. , Leyden Elizabeth , Ansell Stephen M. , Lunning Matthew A. 
Published: May 2023

SummaryThere remains no one standard induction for nodal‐based peripheral T‐cell lymphoma (PTCL). We conducted a phase II study of lenalidomide plus CHOEP as a novel induction strategy. Patients received CHOEP at standard doses in combination with 10 mg of lenalidomide on days 1–10 of a 21‐day cycle for six cycles of therapy followed by observation, high‐dose therapy with autologous stem cell rescue, or maintenance lenalidomide per provider preference. Among 39 patients evaluable for efficacy, the objective response rate after six cycles was 69%, with complete response in 49%, partial response in 21%, stable disease in 0% and progressive disease in 13%. Thirty‐two patients (82%) completed full induction, and seven patients (18%) discontinued for toxicity, primarily hematologic. Any grade hematologic toxicity occurred in over 50% of patients, with grade 3 or 4 febrile neutropenia occurring in 35% of patients despite mandated growth factors. With a median followup of surviving patients of 21.3 months, the estimated 2‐year progression‐free and overall survival were 55% (95% CI 37%–70%) and 78% (95% CI 59%–89%), respectively. In sum, six cycles of lenalidomide plus CHOEP resulted in a modest response rate primarily due to hematologic toxicity, which prevented all patients from completing planned induction.
A Survey of Personalized Interior Design
Authors: Wang Y.T. , Liang C. , Huai N. , Chen J. , Zhang C.J. 
Published: May 2023

AbstractInterior design is the core step of interior decoration, and it determines the overall layout and style of furniture. Traditional interior design is usually laborious and time‐consuming work carried out by professional designers and cannot always meet clients' personalized requirements. With the development of computer graphics, computer vision and machine learning, computer scientists have carried out much fruitful research work in computer‐aided personalized interior design (PID). In general, personalization research in interior design mainly focuses on furniture selection and floor plan preparation. In terms of the former, personalized furniture selection is achieved by selecting furniture that matches the resident's preference and style, while the latter allows the resident to personalize their floor plan design and planning. Finally, the automatic furniture layout task generates a stylistically matched and functionally complete furniture layout result based on the selected furniture and prepared floor plan. Therefore, the main challenge for PID is meeting residents' personalized requirements in terms of both furniture and floor plans. This paper answers the above question by reviewing recent progress in five separate but correlated areas, including furniture style analysis, furniture compatibility prediction, floor plan design, floor plan analysis and automatic furniture layout. For each topic, we review representative methods and compare and discuss their strengths and shortcomings. In addition, we collect and summarize public datasets related to PID and finally discuss its future research directions.
The use of transesophageal echocardiography to predict surgical complexity scoring system for degenerative mitral valve repair
Authors: Bhatt Himani V. , Lisann‐Goldman Lauren , Baron Elvera L. , Salter Benjamin S. , Lin Hung‐Mo , Itagaki Shinobu , Anyanwu Anelechi C. , Adams David H. , Fischer Gregory W. , El‐Eshmawi Ahmed 
Published: May 2023

AbstractBackgroundFor severe mitral valve (MV) degenerative disease, repair is recommended. Prediction of repair complexity and referral to high volume centers can increase rates of successful repair. This study sought to demonstrate that TEE is a feasible imaging modality to predict the complexity of surgical MV repair.MethodsTwo hundred TEE examinations of patients who underwent MV repair (2009–2011) were retrospectively reviewed and scored by two cardiac anesthesiologists. TEE scores were compared to surgical complexity scores, which were previously assigned based on published methods. Kappa values were reported for the agreement of TEE and surgical scores. McNemar's tests were used to test the homogeneity of the marginal probabilities of different scoring categories.ResultsTEE scores were slightly lower (2[1,3]) than surgical scores (3[1,4]). The agreement was 66% between the scoring methods, with a moderate kappa (.46). Using surgical scores as the gold standard, 70%, 71%, and 46% of simple, intermediate and complex surgical scores, respectively, were correctly scored by TEE. P1, P2, P3, and A2 prolapse were easiest to identify with TEE and had the highest agreement with surgical scoring (P1 agreement 79% with kappa .55, P2 96% [kappa .8], P3 77% [kappa .51], A2 88% [kappa .6]). The lowest agreement between the two scores occurred with A1 prolapse (kappa .05) and posteromedial commissure prolapse (kappa .14). In the presence of significant disagreement, TEE scores were more likely to be of higher complexity than surgical. McNemar's test was significant for prolapse of P1 (p = .005), A1 (p = .025), A2 (p = .041), and the posteromedial commissure (p < .0001).ConclusionTEE‐based scoring is feasible for prediction of the complexity of MV surgical repair, thus allowing for preoperative stratification.
On the ambiguity of job search
Authors: Chan Ying Tung , Yip Chi Man 
Published: May 2023

AbstractWho knows the underlying productivity distribution function? Interestingly, this ambiguous function is often referenced to make decisions including job creations, wage determinations, contract formulations, etc. To investigate how ambiguity shapes labor markets, we integrate ambiguity preferences into the Diamond‐Mortensen‐Pissarides (DMP) model. We find that ambiguity‐averse job‐ and talent‐hunters are conservative. Our quantitative analysis indicates that but for the ambiguity, the American unemployment rate would have increased in the postwar era. This paper generalizes the DMP model, enhances our understanding of the labor market, and calls for policies concerning labor market information.
A longitudinal cohort study of mediators of health‐related quality of life after pediatric epilepsy surgery or medical treatment
Authors: Smith Mary Lou , Puka Klajdi , Speechley Kathy N. , Ferro Mark A. , Connolly Mary B. , Major Philippe , Gallagher Anne , Almubarak Salah , Hasal Simona , Ramachandrannair Rajesh , Andrade Andrea , Xu Qi , Leung Edward , Snead O. Carter , Widjaja Elysa 
Published: May 2023

AbstractObjectivesThe purpose of this longitudinal cohort study was to examine the variables that influence health‐related quality of life (HRQOL) after epilepsy surgery in children. We examined whether treatment type (surgical vs medical therapy) and seizure control are related to other variables that have been shown to influence HRQOL, namely depressive symptoms in children with epilepsy or their parents, and the availability of family resources.MethodsIn total, 265 children with drug‐resistant epilepsy were recruited from eight epilepsy centers across Canada at the time of their evaluation for candidacy for epilepsy surgery and were assessed at baseline, 6‐month, 1‐year, and 2‐year follow‐up. Parents completed the Quality of Life in Childhood Epilepsy Questionnaire (QOLCE‐55) and measures of family resources and depression; children completed depression inventories. Causal mediation analyses using natural effect models were used to evaluate the extent to which the relationship between treatment and HRQOL was explained by seizure control, child and parent depressive symptoms, and family resources.ResultsOverall, 111 children underwent surgery and 154 were treated with medical therapy only. The HRQOL scores of surgical patients were 3.4 points higher (95% confidence interval [CI]: −0.2, 7.0) relative to medical patients at the 2‐year follow‐up after adjusting for baseline covariates, with 66% of the effect of surgery attributed to seizure control. Child or parent depressive symptoms and family resources had negligible mediation effects between treatment and HRQOL. The effect of seizure control on HRQOL was not mediated by child or parent depressive symptoms, or by family resources.SignificanceThe findings demonstrate that seizure control is on the causal pathway between epilepsy surgery and improved HRQOL in children with drug‐resistant epilepsy. However, child and parent depressive symptoms and family resources were not significant mediators. The results highlight the importance of achieving seizure control to improve HRQOL.
Von Willebrand Disease: Gaining a global perspective
Authors: O'Sullivan Jamie M. , Tootoonchian Ellia , Ziemele Baiba , Makris Michael , Federici Augusto B. , Khayat Djambas Claudia , El Ekiaby Magdy , Rotellini Dawn , Sidonio Robert F. , Iorio Alfonso , Coffin Donna , Pierce Glenn F. , Stonebraker Jeffrey , James Paula D. , Lavin Michelle 
Published: May 2023

AbstractIntroductionRecent guidelines for von Willebrand Disease (VWD) highlighted the challenges in diagnosis and management. Identifying the number of persons with VWD (PwVWD) internationally will help target support to aid diagnosis of PwVWD.AimTo examine international registration rates of PwVWD, the influence of income status, geographical region and the age and sex profile. Cumulatively, these data will be used to inform future strategy from the World Federation of Haemophilia (WFH) to address unmet clinical and research needs.MethodsData from the 2018/2019 WFH Annual Global Survey (AGS) were analysed, providing a global perspective on VWD registration.ResultsRegistration rates are lowest in South Asia (0.6/million population) and highest in Europe/Central Asia (50.9/million population, 0.005%), but below the expected prevalence rate (0.1%). National economic status impacted VWD registration rates, reflecting variation in access to optimal healthcare infrastructure. Females represented the majority of PwVWD globally, however, in low‐income countries (LIC) males predominated. Age profile varied, with markedly higher rates of paediatric registrations in North America, Middle East and North Africa and South Asia. Rates of type 3 VWD registrations were significantly influenced by economic status (81% of VWD diagnoses in LIC), suggesting only the most severe VWD types are diagnosed in resource limited settings.ConclusionSignificant variation in registration rates of PwVWD exist internationally and is influenced by income status and the presence of HTC networks. Improved understanding of registration rates will enable targeting of advocacy to improve awareness, diagnosis and support for PwVWD internationally.Key points
Registration rates of People with Von Willebrand Disease (PwVWD) vary internationally and are influenced by national income status
Although females represent the majority of PwVWD globally, in low income countries (LIC) males predominated, possibly related to stigma surrounding gynaecological bleeding.
Rates of type 3 VWD registration were significantly influenced by economic status (81% of VWD diagnoses in LIC), suggesting only the most severe VWD types are diagnosed in resource limited settings.
Basement membrane thickness helps to differentiate hypopigmented mycosis fungoides from clinical and pathological mimickers
Authors: Abdelkader Heba A. 
Published: May 2023

AbstractBackgroundHypopigmented mycosis fungoides (HMF) is a relatively rare subtype of mycosis fungoides (MF). The diagnosis of HMF can be quite challenging in case of insufficient diagnostic criteria due to the diverse conditions that present with hypopigmented lesions. This study aimed to evaluate the usefulness of the assessment of the basement membrane thickness (BMT) in the diagnosis of HMF.MethodsA retrospective study was conducted on biopsy specimens of 21 HMF and 25 non‐HMF cases who presented with hypopigmented lesions. The thickness of the basement membrane was evaluated in periodic acid‐Schiff (PAS)‐stained sections.ResultsThe mean BMT was significantly higher in the HMF group than in the non‐HMF group (P < 0.001). The best cut‐off value of mean BMT for the detection of HMF verified in ROC analysis was 32.7 μm (P < 0.001) with a sensitivity of 85.7% and a specificity of 96%.ConclusionEvaluation of BMT can be a useful tool to distinguish HMF from other causes of hypopigmented lesions in doubtful cases. We suggest the use of “ BMT more than 33 μm” as a histopathologic criterion of HMF.
Cryoprotective effect of three oligosaccharides on freezing–thawing induced krill mince: with emphasis on physicochemical changes and gelation properties
Authors: Wang Yueyue , Jiang Pengfei , Fu Baoshang , Qi Libo , Shang Shan 
Published: May 2023

SummaryThe physicochemical and gelation properties of krill mince were investigated in relation to the cryoprotective effect of kappa‐carrageenan (KC), carrageenan oligosaccharides (CGO), chitosan oligosaccharides (COS), and alginate oligosaccharides (AOS). The water‐holding capacity of krill mince decreased during freezing–thawing (FT) circles, but KC and three oligosaccharides prevented this decline by increasing hydrogen and ionic bonding. The denaturation and degradation of proteins in krill samples added with oligosaccharides were alleviated with less decrease in protein solubility and Ca2+‐ATPase activity, as well as higher intensity protein bands of myosin heavy chain and paramyosin subject to 9‐FT circles. The notable increase in TBARS value (P < 0.05) was observed after 3‐FT circles, however, with relatively lower values with the addition of AOS and CGO, demonstrating antioxidative ability against lipid oxidation. Additionally, CGO exhibited higher protein secondary structure maintenance stability, evidenced by a less dramatic decrease in α‐helical fraction than other oligosaccharides. The overall gelation and textural properties of krill mince with CGO could be better maintained with no more than 3‐FT circles.
Physicochemical characteristics of air classification products of sprouted wheat (Zhoumai 27) flour
Authors: Guo Jia , Feng Chunlu , Bian Ke 
Published: May 2023

SummarySprouting negatively impacts wheat processing and edibility. Sprouted wheat flour (SWF) was air‐classified into three categories based on particle sizes, F1 (>45 μm), F2 (20–45 μm), and F3 (<20 μm). The sizes were examined using a laser particle size analyser and scanning electron microscopy. Their components, such as starch, protein properties, rheology, and dough microstructure, were also examined. After air classification, reducing sugar, damaged starch, amylase, protease, and inferior gluten components were primarily concentrated in F3. Decreasing particle size considerably impaired gelation strength, gluten quality, rheology properties, and dough microstructure. Compared with SWF, these characteristics significantly improved in F1. The results suggested that air classification could induce SWF component fractionation. The inferior components that reduce the quality of SWF were enriched in fine flour. Thus, removing these inferior components can considerably improve SWF rheological quality and dough structure. These results can provide useful information on the important effect of air classification on the quality of SWF products. Moreover, the study findings provide a reference for future application of air classification of SWF.