bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interdisziplinäre Empfehlungen zur Behandlung des fortgeschrittenen Nierenzellkarzinoms
Authors: Miller Kurt , Bergmann Lothar , Doehn Christian , Grünwald Viktor , Gschwend Jürgen E. , Ivanyi Philipp , Kuczyk Markus A. 
Published: July 2023

ZusammenfassungIn den letzten zwei Jahren sind Anti-VEGFR-Tyrosinkinase-Inhibitoren (TKI) in der Erstlinientherapie des fortgeschrittenen Nierenzellkarzinom nahezu komplett durch Immuntherapie-Kombinationen mit Checkpoint-Inhibitoren ersetzt worden. Die Prognose der Patienten konnte damit nochmals deutlich verbessert werden. In den entsprechenden Zulassungsstudien wurden mediane Überlebenszeiten von drei bis vier Jahren erreicht. Die TKI-Monotherapie hat bei günstigem Progressionsrisiko, bei Kontraindikationen gegen eine Immuntherapie und im Kontext der SARS-CoV-2-Pandemie aber weiterhin einen Stellenwert.Die Frage, welche Therapie für welche Patient/-innen geeignet ist, stellt sich vor dem Hintergrund von zwei CPI-TKI-Kombinationen und einer reinen CPI-Kombination als neuem Erstlinien-Standard auf einer neuen Basis. Temsirolimus und die Kombination Bevacizumab + Interferon-alpha spielen nahezu keine Rolle mehr. In der Zweitlinientherapie wurde für Nivolumab und Cabozantinib nach TKI-Vortherapie ein signifikanter Überlebensvorteil gegenüber Everolimus gezeigt. Die Kombination Lenvatinib + Everolimus sowie Axitinib sind weitere zugelassene Substanzen. Auch für TKI liegen Daten vor, allerdings mit begrenzter Aussagekraft. Everolimus als Monotherapie ist durch die neuen Optionen in der Zweitlinie abgelöst worden. Insgesamt fehlt es an Biomarkern, die bei der Therapiewahl unterstützen könnten. Die kürzlich erfolgte Aktualisierung der S3-Leitlinie war daher ein wichtiger Schritt, um evidenzbasiert in der klinischen Praxis Orientierung zu geben.Bei potenziell komplexeren Therapiealgorithmen und gleichzeitig nur wenig Evidenz muss auch die Frage nach der optimalen Sequenztherapie neu diskutiert werden. Die meisten Zweitlinien-Optionen wurden nach Versagen einer gegen VEGF-gerichteten TKI-Therapie geprüft, die nur noch für eine Minderheit der Patient/-innen infrage kommt.Im Rahmen eines interdisziplinären Expertengesprächs wurden im November 2020 die aktuelle Datenlage einschließlich neuerer Studienergebnisse sowie relevante Kriterien für die individuelle Therapieentscheidung diskutiert. Auch die SARS-CoV-2-Pandemie fand dabei Berücksichtigung. Ziel war es, gemeinsame Empfehlungen auf Basis der aktuell publizierten Daten und der eigenen klinischen Erfahrung für den Praxisalltag abzuleiten. Die Ergebnisse werden in dieser Publikation vorgestellt.
A Review of Mental Health Issues in High-Performance and Elite-Level
Cycling
Authors: Smith Alexander , Buadze Ana , Colangelo Jill , Liebrenz Michael 
Published: July 2023

AbstractDespite the public health benefits of cycling in the general population, mental
health issues may be evident in high-performance and elite-level competitive
domains. With prominent riders disclosing their experiences with psychiatric
symptoms, distinctive socioenvironmental factors could exacerbate
psychopathological vulnerabilities. This suggests a need for greater mental
health awareness amongst stakeholders, supplemented by actions from
international and national federations and regulators. To synthesise relevant
observations about psychiatric concerns in high-performance and elite-level
cycling, we conducted a keyword search of articles in APA PsycINFO, PubMed, and
Scopus based on specified exclusion criteria. Thirteen papers were identified
that examined mental health issues in high-performance and/or
elite-level cycling per classifications from the World Health
Organization’s International Classification of Diseases 11th Revision. A
large proportion of articles illustrated eating disorder symptomatology, but
others discussed attention deficit/hyperactivity disorder, anxiety
disorder, depression, sleep wake disorders, and substance use disorder. Existing
literature underlines important considerations for all stakeholders within the
cycling community around mental health initiatives and care provisions, which
are currently lacking across the sport. Such programmes could incorporate
consensus statements, psychiatric screening, psychoeducation, stigma-reducing
policies, and athlete advocacy. These can help mitigate socioenvironmental risk
factors and prioritise athlete wellbeing over performance-centred
motivations.
Excisão de tumor fibroso solitário na chanfradura ciática com compressão do nervo ciático – Um raro caso clínico
Authors: Fontainhas Tiago , Costa Ana Sofia , Sousa Rui , Resende Ana Flávia , Nelas João , Pereira David 
Published: July 2023

ResumoÉ apresentado um caso clínico de uma paciente de 41 anos, sem antecedentes pessoais de relevo, que foi estudada por dor abdominal difusa autolimitada, tendo sido detectada incidentalmente uma massa tumoral extrabdominal, extraperitoneal ao nível da chanfradura ciática direita. Durante o estudo do caso, a doente resolveu as queixas abdominais, mas desenvolveu quadro de ciatalgia, irradiada para o pé direito e dor tipo choque elétrico. Biópsia guiada por TAC revelou tratar-se de uma neoplasia mesenquimatosa dos tecidos moles, de baixo grau, com características que a enquadram em um tumor fibroso solitário extrapleural. A paciente foi referenciada para a equipe de bacia do serviço de ortopedia para excisão cirúrgica da lesão, tendo sido operada sem intercorrências – excisão total da lesão, com margens livres, foi obtida e o exame anatomopatológico foi compatível com o realizado na biópsia. Após excisão da lesão, ocorreu resolução completa dos sintomas relacionados com compressão do nervo ciático.
Osteotomia de redução da cabeça femoral por sequelas de doença de Legg-Calvé-Perthes: Relato de caso
Authors: Fontainhas Tiago , Pereira David , Costa Ana Sofia , Sousa Rui , Resende Ana Flávia , Nelas Joaquim 
Published: July 2023

ResumoA doença de Legg-Calvé-Perthes (DLCP) origina comumente sequelas na morfologia da articulação coxofemoral. Uma variante comum é a cabeça do fêmur não-esférica e sobredimensionada, associada a um colo femoral curto e grande trocânter elevado, que origina conflito femuroacetabular (CFA). A inovadora técnica de luxação cirúrgica do quadril de Ganz abriu novas possibilidades de tratamento para CFA, incluindo a originada por sequelas de DLCP, sem aumentar o risco de necrose avascular da cabeça femoral. Na coxa magna elipsoide resultante de DLCP, constatou-se que o desgaste articular era mais acentuado na porção central da cabeça do fêmur e que o terço lateral está íntegro, pois não articula com o acetábulo. Para estes casos, foi desenvolvida a técnica de osteotomia de redução da cabeça femoral, que resseca a porção danificada da cabeça femoral e restabelece a sua esfericidade. Os resultados a curto prazo são encorajadores. O presente relato de caso apresenta um paciente com sequelas de DLCP tratado com osteotomia de redução da cabeça femoral.
Current Trends in Vaccine Development for Hereditary Colorectal Cancer Syndromes
Authors: Bowen Charles M. , Sinha Krishna M. , Vilar Eduardo 
Published: July 2023

AbstractThe coming of age for cancer treatment has experienced exponential growth in the last decade with the addition of immunotherapy as the fourth pillar to the fundamentals of cancer treatment—chemotherapy, surgery, and radiation—taking oncology to an astounding new frontier. In this time, rapid developments in computational biology coupled with immunology have led to the exploration of priming the host immune system through vaccination to prevent and treat certain subsets of cancer such as melanoma and hereditary colorectal cancer. By targeting the immune system through tumor-specific antigens—namely, neoantigens (neoAgs)—the future of cancer prevention may lie within arm's reach by employing neoAg vaccines as an immune-preventive modality for hereditary cancer syndromes like Lynch syndrome. In this review, we discuss the history, current trends, utilization, and future direction of neoAg-based vaccines in the setting of hereditary colorectal cancer.
Hereditary Colorectal Cancer Syndromes Registry: What, How, and Why?
Authors: Abbass Mohammad Ali , Poylin Vitaliy , Strong Scott 
Published: July 2023

AbstractCaring for patients with colorectal cancer inherited cancer syndromes is complex, and it requires a well-thought integration process between a multidisciplinary team, an accessible database, and a registry coordinator. This requires an aligned vision between the administrative business team and the clinical team.Although we can manage most of the cancers that those patients develop according to oncologic guidance, the future risk of patients and their families might add emotional and psychological burdens on them in the absence of a well-qualified and trained team where balancing quality of life and cancer risk are at the essence of decision making.
Frequency of OXA-Type carbapenemases among carbapenem-resistant Acinetobacter baumannii in clinical isolates from adult intensive care unit in India
Authors: Seshatri Shanmugapriya , Charan Jaykaran , Tak Vibhor , Nag Vijaya Lakshmi , Varthya Shoban Babu , Ambwani Sneha 
Published: July 2023

Objectives:
Acinetobacter baumannii is a highly virulent bacteria in modern health care, with a high ability to acquire antimicrobial resistance. Carbapenemases production appears to be the most common mechanism involved in drug resistance to carbapenem. As the prevalence of carbapenem-resistant A. baumannii was high in intensive care unit (ICU) patients, this study was designed to find the frequency of oxacillinases (OXA) genes including OXA-23, OXA-24, OXA-51, and OXA-58.

Materials and Methods:
A clinical specimen was collected from patients admitted to the adult ICU. DNA was isolated from carbapenem-resistant A. baumannii and amplified using conventional polymerase chain reaction technique and gel electrophoresis for visualization of results.

Statistical Analysis:
Data were entered into Microsoft Excel and was analyzed using SPSS version 23 (IBM SPSS statistics, Somers New York, United States).

Results:
The frequency of the OXA-23 gene was high with 87.5%, followed by OXA-51 gene with 73.2%. All 56 isolates were negative for the OXA-24 and OXA-58 genes. We also found that both OXA-23 and OXA-51 genes coexisted in 40 (71.4%) isolates. No significant difference was found between drug-resistant genes (OXA-23 and OXA-51) and clinical outcomes. The relationship between the presence of OXA gene was compared between survivors and nonsurvivors, which was found out to be nonsignificant. The presence of OXA genes showed no significant increase in the length of hospital stay. The significant association between acute physiology and chronic health evaluation IV scores and clinical outcome was calculated, and it was evident in the comparison of the discharged and died groups.

Conclusion:
Early detection of these drug-resistant genes by molecular methods is essential in decreasing the spread of carbapenem-resistant A. baumannii.
Is there power in Mad knowledge?
Authors: Rose Diana 
Published: July 2023

AbstractThis paper addresses some conceptual and organizational questions which bear on the issue of whether those designated mad can produce knowledge from, about, and beyond their experience. Ideas encapsulated in concepts such as lack of reason and epistemic justice are deployed as well as the individuation that characterizes both the clinical encounter and services generally. It is argued that these prevent such knowledge making in itself and dissipate the structures which would enable it. The paper looks at ways in which the silencing of the mad has been broken and at responses which suppress or recuperate such developments. It argues, nonetheless, that counter-narratives are being established that resist these responses. Several empirical studies provide evidence to support the argument.
Superconductivity determined by the S–H framework in CH4-inserted S–H framework hydrides under high pressures
Authors: Yao Shunwei , Hu Wenjing , Wang Ben , Peng Lin , Shi Tingting , Liu Xiaolin , Chen Jing , Lin Jia , Yao Dao-Xin , Chen Xianfeng 
Published: July 2023

Recently, a debate is raising the concern of possible carbonaceous sulfur hydrides with room-temperature superconductivity around 270 GPa. In order to systematically investigate the structural information and relevant natures of C–S–H superconductors, we performed an extremely extensive structure search and first-principles calculations under high pressures. As a result, the metastable stoichiometries of CSH7, C2SH14, CS2H10, and CS2H11 were unveiled under high pressure, which can be viewed as CH4 units inserted into the S–H framework. Given the super-high superconductivity of Im3̄m-SH3, we performed electron–phonon coupling calculations of these compounds,the metastable of R3m-CSH7, Cm-CSH7, Cm-CS2H10, P3m1-CS2H10, Cm-CS2H11, and Fmm2-CS2H11 are predicted to become good phonon-mediated superconductors that could reach Tc of 130, 120, 72, 74, 92, and 70 K at 270 GPa, respectively. Furthermore, we identified that high Tc is associated with the large contribution of the S–H framework to the electron density of states near the Fermi level. Our results highlight the importance of the S–H framework in superconductivity and verify that the suppression of density of states of these carbonaceous sulfur hydrides by CH4 units results in Tc lower than that of Im3̄m-SH3, which could act as a useful guidance in the design and optimization of high-Tc superconductors in these and related systems.
Metacognitive approaches to collaborative writing
Authors: Sato Masatoshi 
Published: July 2023

Collaborative writing (CW) presents unique L2
learning opportunities. While previous research primarily used
cognitive and social approaches, the current chapter proposes a
metacognitive approach to (1) advance our understanding of how CW
supports L2 learning, and (2) explore pedagogical ideas that may
further enhance CW effectiveness, that is, metacognitive instruction
on CW. Three CW features relevant to both face-to-face and
technology-mediated communication will be focused on. First,
collaborative interaction – a prerequisite for CW to be effective –
can be explained by metacognitive theories. Second, the provision
and incorporation of feedback may be related to learners’
metacognition. Third, the CW sequence – planning what to write,
drafting a text, and editing the text together – closely corresponds
to metacognitive regulatory skills, that is, planning, monitoring,
and evaluation.
Unsupervised learning in hexagonal boron nitride memristor-based spiking neural networks
Authors: Afshari Sahra , Xie Jing , Musisi-Nkambwe Mirembe , Radhakrishnan Sritharini , Sanchez Esqueda Ivan 
Published: July 2023

Abstract
Resistive random access memory (RRAM) is an emerging non-volatile memory technology that can be used in neuromorphic computing hardware to exceed the limitations of traditional von Neumann architectures by merging processing and memory units. Two-dimensional (2D) materials with non-volatile switching behavior can be used as the switching layer of RRAMs, exhibiting superior behavior compared to conventional oxide-based devices. In this study, we investigate the electrical performance of 2D hexagonal boron nitride (h-BN) memristors towards their implementation in spiking neural networks (SNN). Based on experimental behavior of the h-BN memristors as artificial synapses, we simulate the implementation of unsupervised learning in SNN for image classification on the Modified National Institute of Standards and Technology dataset. Additionally, we propose a simple spike-timing-dependent-plasticity (STDP)-based dropout technique to enhance the recognition rate in h-BN memristor-based SNN. Our results demonstrate the viability of using 2D-material-based memristors as artificial synapses to perform unsupervised learning in SNN using hardware-friendly methods for online learning.
Enhanced photocatalytic activity and antiviral evaluation of CuO@Fe2O3 NC for amoxicillin degradation and SARS-CoV-2 treatment
Authors: Legmairi Souheila , Meneceur Souhaila , Hasan Gamil Gamal , Eddine Laouini Salah , Mohammed Hamdi Ali , Alharthi Fahad , Abdullah Johar Amin Ahmed 
Published: July 2023

Abstract
Copper oxide nanoparticles (CuO NPs) and CuO NPs decorated with hematite (Fe2O3) nanocomposites (CuO@Fe2O3 NC) were biosynthesized by a green method using Portulaca oleracea leaves extract. The NC were characterized using various techniques, including x-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive x-ray spectroscopy, and UV–vis spectroscopy. The results showed that the synthesized CuO and CuO@Fe2O3 NC were crystalline with a monoclinic crystal structure and contained functional groups responsible for catalytic activity. The size of the nanocomposites ranged from 39.5 to 45.9 nm, and they exhibited a variety of agglomerated or aggregated shapes. The CuO@Fe2O3 NC showed improved photocatalytic activity for the degradation of antibiotics in water and wastewater and promising antiviral activity against SARS-CoV-2, indicating its potential for use in disinfection applications. The study investigated the impact of irradiation time on the photocatalytic degradation of Amoxicillin and found that increasing the irradiation time led to a higher degradation rate. The band gap energy (E
g) for pure CuO NPs was around 2.4 eV and dropped to 1.6 eV with CuO@Fe2O3 NC. In summary, the CuO@Fe2O3 NC has the potential to be an efficient photocatalyst and promising antiviral agent for environmental remediation. The CuO@Fe2O3 nanocomposites have been found to possess a high degree of efficacy in inactivating SARS-CoV-2 infectivity. The results of the study indicate that the nanocomposites exhibit potent anti-viral properties and hold significant potential for use in mitigating the spread of the virus.
A new dental CBCT metal artifact reduction method based on a dual-domain processing framework
Authors: Tang Hui , Lin Yu Bing , Jiang Su Dong , Li Yu , Li Tian , Bao Xu Dong 
Published: July 2023

Abstract

Objective. Cone beam computed tomography (CBCT) has been wildly used in clinical treatment of dental diseases. However, patients often have metallic implants in mouth, which will lead to severe metal artifacts in the reconstructed images. To reduce metal artifacts in dental CBCT images, which have a larger amount of data and a limited field of view compared to computed tomography images, a new dental CBCT metal artifact reduction method based on a projection correction and a convolutional neural network (CNN) based image post-processing model is proposed in this paper. Approach. The proposed method consists of three stages: (1) volume reconstruction and metal segmentation in the image domain, using the forward projection to get the metal masks in the projection domain; (2) linear interpolation in the projection domain and reconstruction to build a linear interpolation (LI) corrected volume; (3) take the LI corrected volume as prior and perform the prior based beam hardening correction in the projection domain, and (4) combine the constructed projection corrected volume and LI-volume slice-by-slice in the image domain by two concatenated U-Net based models (CNN1 and CNN2). Simulated and clinical dental CBCT cases are used to evaluate the proposed method. The normalized root means square difference (NRMSD) and the structural similarity index (SSIM) are used for the quantitative evaluation of the method. Main results. The proposed method outperforms the frequency domain fusion method (FS-MAR) and a state-of-art CNN based method on the simulated dataset and yields the best NRMSD and SSIM of 4.0196 and 0.9924, respectively. Visual results on both simulated and clinical images also illustrate that the proposed method can effectively reduce metal artifacts. Significance. This study demonstrated that the proposed dual-domain processing framework is suitable for metal artifact reduction in dental CBCT images.
Calculation of the DNA damage yield and relative biological effectiveness in boron neutron capture therapy via the Monte Carlo track structure simulation
Authors: Han Yang , Geng Changran , Liu Yuanhao , Wu Renyao , Li Mingzhu , Yu Chenxi , Altieri Saverio , Tang Xiaobin 
Published: July 2023

Abstract

Objective. Boron neutron capture therapy (BNCT) is an advanced cellular-level hadron therapy that has exhibited remarkable therapeutic efficacy in the treatment of locally invasive malignancies. Despite its clinical success, the intricate nature of relative biological effectiveness (RBE) and mechanisms responsible for DNA damage remains elusive. This work aims to quantify the RBE of compound particles (i.e. alpha and lithium) in BNCT based on the calculation of DNA damage yields via the Monte Carlo track structure (MCTS) simulation. Approach. The TOPAS-nBio toolkit was employed to conduct MCTS simulations. The calculations encompassed four steps: determination of the angle and energy spectra on the nuclear membrane, quantification of the database containing DNA damage yields for ions with specific angle and energy, accumulation of the database and spectra to obtain the DNA damage yields of compound particles, and calculation of the RBE by comparison yields of double-strand break (DSB) with the reference gamma-ray. Furthermore, the impact of cell size and microscopic boron distribution was thoroughly discussed. Main results. The DSB yields induced by compound particles in three types of spherical cells (radius equal to 10, 8, and 6 μm) were found to be 13.28, 17.34, 22.15 Gy Gbp−1 for boronophenylalanine (BPA), and 1.07, 3.45, 8.32 Gy Gbp−1 for sodium borocaptate (BSH). The corresponding DSB-based RBE values were determined to be 1.90, 2.48, 3.16 for BPA and 0.15, 0.49, 1.19 for BSH. The calculated DSB-based RBE showed agreement with experimentally values of compound biological effectiveness for melanoma and gliosarcoma. Besides, the DNA damage yield and DSB-based RBE value exhibited an increasing trend as the cell radius decreased. The impact of the boron concentration ratio on RBE diminished once the drug enrichment surpasses a certain threshold. Significance. This work is potential to provide valuable guidance for accurate biological-weighted dose evaluation in BNCT.
A kinetic Monte Carlo study of positive streamer interaction with complex dielectric surfaces
Authors: Marskar R , Meyer H K H 
Published: July 2023

Abstract
We present a computational study of positive streamers in air propagating over dielectric plates with square channels running orthogonal to the propagation direction. The study uses a newly developed non-kinetic Particle-In-Cell model based on Îto diffusion and kinetic Monte Carlo, which does not introduce artificial smoothing of the plasma density or photo-electron distributions. These capabilities permit the computational study to use high-resolution grids with large time steps, and also incorporates geometric shielding for particle and photon transport processes. We perform Cartesian 2D simulations for channel dimensions ranging from 250 µm to 2 mm, and track streamers over a distance of 4 cm and times ranging up to 300 ns, for various voltages ranging from 15 kV to 30 kV. These baseline simulations are supplemented by additional studies on the effects of transparency to ionizing radiation, streamer reignition, dielectric permittivity, and 3D effects. The computer simulations show: 1) Larger channels restrict streamer propagation more efficiently than narrow channels, and can lead to arrested surface streamers. 2) Geometric shielding of ionizing radiation substantially reduces the number of starting electrons in neighboring channels, and thus also reduces the onset point of streamer reignition. 3) Decreasing the streamer channel separation leads to slower streamers. 4) Increasing the dielectric permittivity increases the discharge velocity. The results are of generic value to fields of research involving streamer-dielectric interactions, and in particular for high-voltage technology where streamer termination is desirable.