bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-stage revision anterior cruciate ligament reconstruction reduces failure risk but leads to lesser clinical outcomes than single-stage revision after primary anterior cruciate ligament graft failure: a retrospective cohort study
Authors: Ifarraguerri Anna M. , Graham George D. , White Alexander B. , Berk Alexander N. , Gachigi Kennedy K. , Siparsky Patrick N. , Trofa David P. , Piasecki Dana P. , Fleischli James E. , Saltzman Bryan M. 
Published: January 2025

Abstract

Background
There are no studies that compare the outcomes and complications of single-versus two-stage revision anterior cruciate ligament reconstruction (ACLR) after primary ACLR failure. This purpose of this study is to examine clinical and functional outcomes and complications associated with single and two-stage revision ACLR after primary ACLR failure.

Methods
All patients who underwent single or two-stage revision ACLR after primary ACLR failure between 2012 and 2021 with a minimum of a 2 year follow-up were included. Patients were excluded if they were not treated at our single academic institution, had inadequate follow-up, or had incomplete medical records. Revision intraoperative data, concomitant injuries, and complications were collected by chart review. Return to sport, numerical pain rating scale (NPRS) score, Knee injury and Osteoarthritis Outcome Score (KOOS), and Veteran Rands 12-item health survey (VR-12 scores) were collected.

Results
The final analysis included 176 patients. A total of 147 (83.5%) had a single-stage revision ACLR (87 male, 60 female), and 29 (16.5%) had a two-stage revision ACLR (13 male, 16 female). Two-stage revision ACLR was significantly associated with anterior knee pain [odds ratio (OR) 4.36; 95% confidence interval (CI) 1.5 to 12.65; P = 0.007] but with lower failure rates (OR 0.12, 95% CI 0.02 to 0.9; P = 0.04). On multivariate analysis, a two-stage revision ACLR reduced the risk of graft failure by 85% (OR 0.15; 95% CI 0.02 to 1.17; P = 0.07). Two-stage revision ACLR was significantly associated with a lower KOOS pain score (OR −11.7; 95% CI −22.35 to −1.04; P = 0.031), KOOS symptoms score (OR −17.11; 95% CI −28.85 to −5.36; P = 0.004), KOOS Activities of Daily Living (ADL) score (OR −11.15; 95% CI −21.71 to −0.59; P = 0.039) and Veterans RAND 12-Item Health Survey (VR-12) physical component score (OR −9.99; 95% CI −15.77 to −4.22; P = 0.001).

Conclusions
The clinical outcomes and subjective patient scores significantly differed between the single-stage and two-stage revision ACLR after primary ACLR failure. Patients with a two-stage revision ACLR had a significantly reduced risk of revision graft failure but higher rates of postoperative anterior knee pain, lower pain scores, and lesser knee functional scores than single-stage revision patients.

Study design
Retrospective cohort study; level of evidence, 3
Self-harm in women in midlife: rates, precipitating problems and outcomes following hospital presentations in the multicentre study of self-harm in England
Authors: Clements Caroline , Bickley Harriet , Hawton Keith , Geulayov Galit , Waters Keith , Ness Jennifer , Kelly Samantha , Townsend Ellen , Appleby Louis , Kapur Nav 
Published: January 2025

Background
Suicide in women in the UK is highest among those in midlife. Given the unique changes in biological, social and economic risk factors experienced by women in midlife, more information is needed to inform care.

Aim
To investigate rates, characteristics and outcomes of self-harm in women in midlife compared to younger women and identify differences within the midlife age-group.

Method
Data on women aged 40–59 years from the Multicentre Study of Self-harm in England from 2003 to 2016 were used, including mortality follow-up to 2019, collected via specialist assessments and/or emergency department records. Trends were assessed using negative binomial regression models. Comparative analysis used chi-square tests of association. Self-harm repetition and suicide mortality analyses used Cox proportional hazards models.

Results
The self-harm rate in midlife women was 435 per 100 000 population and relatively stable over time (incident rate ratio (IRR) 0.99, p < 0.01). Midlife women reported more problems with finances, alcohol and physical and mental health. Suicide was more common in the oldest midlife women (hazard ratio 2.20, p < 0.01), while psychosocial assessment and psychiatric inpatient admission also increased with age.

Conclusion
Addressing issues relating to finances, mental health and alcohol misuse, alongside known social and biological transitions, may help reduce self-harm in women in midlife. Alcohol use was important across midlife while physical health problems and bereavement increased with age. Despite receiving more intensive follow-up care, suicide risk in the oldest women was elevated. Awareness of these vulnerabilities may help inform clinicians’ risk formulation and safety planning.
Associations of mental disorders in children with parents' subsequent mental disorders: nationwide cohort study from Finland and Denmark
Authors: Hakulinen Christian , Gutvilig Mai , Niemi Ripsa , Momen Natalie C. , Pulkki-Råback Laura , Böckerman Petri , Plana-Ripoll Oleguer , Komulainen Kaisla , Elovainio Marko 
Published: January 2025

Background
Intergenerational transmission of mental disorders has been well established, but it is unclear whether exposure to a child's mental disorder increases parents' subsequent risk of mental disorders.

Aims
We examined the association of mental disorders in children with their parents' subsequent mental disorders.

Method
In this population-based cohort study, we included all individuals with children born in Finland or Denmark in 1990–2010. Information about mental disorders was acquired from national registers. The follow-up period began when the parent's eldest child was 5 years old (for ICD-10 codes F10–F60) or 1 year old (for codes F70–F98) and ended on 31 December 2019 or when the parent received a mental disorder diagnosis, died, or emigrated from Finland or Denmark. The associations of mental disorders in children with their parents' subsequent mental disorders were examined using Cox proportional hazards models.

Results
The study cohort included 1 651 723 parents. In total, 248 328 women and 250 763 men had at least one child who had been diagnosed with a mental disorder. The risk of a parent receiving a mental disorder diagnosis was higher among those who had a child with a mental disorder compared with those who did not. For both parents, the hazard ratios were greatest in the first 6 months after the child's diagnosis (hazard ratio 2.04–2.54), followed by a subtle decline in the risk (after 2 years, the hazard ratio was 1.33–1.77).

Conclusion
Mental disorders in children are associated with a greater risk of subsequent mental disorders among their parents. Additional support is needed for parents whose children have been recently diagnosed with a mental disorder.
Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis
Authors: Benarous Xavier , Lahaye Hélène , Consoli Angèle , Cohen David , Labelle Réal , Guilé Jean-Marc 
Published: January 2025

Abstract

Background
This systematic review and meta-analysis evaluates the prevalence of disruptive mood dysregulation disorders (DMDD) in community-based and clinical populations.

Methods
PubMed and PsychINFO databases were searched, using terms specific to DMDD, for studies of prevalence and comorbidity rates conducted in youths below 18.

Results
Fourteen studies reporting data from 2013 to 2023 were included. The prevalence of DMDD in the community-based samples was 3.3% (95% confidence interval [CI], 1.4–6.0) and 21.9% (95% CI, 15.5–29.0) in the clinical population. The differences in the identification strategy of DMDD were associated with significant heterogeneity between studies in the community-based samples, with a prevalence of 0.82% (95% CI, 0.11–2.13) when all diagnosis criteria were considered. Anxiety, depressive disorders, and ADHD were the most frequent comorbidity present with DMDD. The association with other neurodevelopmental disorders remained poorly investigated.

Conclusions
Caution is required when interpreting these findings, considering the quality of the reviewed data and the level of unexplained heterogeneity among studies. This review stresses the importance of considering a strict adhesion to DMDD criteria when exploring its clinical correlates.
Quantitative approaches for studying G protein-coupled receptor signalling and pharmacology
Authors: Pearce Abigail , Redfern-Nichols Theo , Wills Edward , Rosa Matthew , Manulak Iga , Sisk Claudia , Huang Xianglin , Atakpa-Adaji Peace , Prole David L. , Ladds Graham 
Published: January 2025

ABSTRACT
G protein-coupled receptor (GPCR) signalling pathways underlie numerous physiological processes, are implicated in many diseases and are major targets for therapeutics. There are more than 800 GPCRs, which together transduce a vast array of extracellular stimuli into a variety of intracellular signals via heterotrimeric G protein activation and multiple downstream effectors. A key challenge in cell biology research and the pharmaceutical industry is developing tools that enable the quantitative investigation of GPCR signalling pathways to gain mechanistic insights into the varied cellular functions and pharmacology of GPCRs. Recent progress in this area has been rapid and extensive. In this Review, we provide a critical overview of these new, state-of-the-art approaches to investigate GPCR signalling pathways. These include novel sensors, Förster or bioluminescence resonance energy transfer assays, libraries of tagged G proteins and transcriptional reporters. These approaches enable improved quantitative studies of different stages of GPCR signalling, including GPCR activation, G protein activation, second messenger (cAMP and Ca2+) signalling, β-arrestin recruitment and the internalisation and intracellular trafficking of GPCRs.
Multicell Experiments for Marginal Treatment Effect Estimation of Digital Ads
Authors: Waisman Caio , Gordon Brett R. 
Published: January 2025

Randomized experiments with treatment and control groups are an important tool to measure the impacts of interventions. However, in experimental settings with one-sided noncompliance extant empirical approaches may not produce the estimands a decision maker needs to solve the problem of interest. For example, these experimental designs are common in digital advertising settings but typical methods do not yield effects that inform the intensive margin: how many consumers should be reached or how much should be spent on a campaign. We propose a solution that combines a novel multicell experimental design with modern estimation techniques that enables decision makers to solve problems with an intensive margin. Our design is straightforward to implement and does not require additional budget. We illustrate our method through simulations calibrated using an advertising experiment at Facebook, demonstrating its superior performance in various scenarios and its advantage over direct optimization approaches. This paper was accepted by Jean-Pierre Dubé, marketing. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.01185 .
Estimating the burden of underdiagnosis within England: A modelling study of linked primary care data
Authors: Anosova Olga , Head Anna , Collins Brendan , Alexiou Alexandros , Darras Kostas , Sutton Matt , Cookson Richard , Anselmi Laura , O’Flaherty Martin , Barr Ben , Kypridemos Chris 
Published: January 2025

Introduction
Undiagnosed chronic disease has serious health consequences, and variation in rates of underdiagnosis between populations can contribute to health inequalities. We aimed to estimate the level of undiagnosed disease of 11 common conditions and its variation across sociodemographic characteristics and regions in England.

Methods
We used linked primary care, hospital and mortality data on approximately 1.3 million patients registered at a GP practice for more than one year from 01/04/2008–31/03/2020 from Clinical Practice Research Datalink. We created a dynamic state model with six states based on the diagnosis and mortality of 11 conditions: coronary heart disease (CHD), stroke, hypertension, chronic obstructive pulmonary disease, type 2 diabetes, dementia, breast cancer, prostate cancer, lung cancer, colorectal cancer, and depression/anxiety. Undiagnosed disease was conceptualised as those who died with a condition but were not previously diagnosed. This was combined with observed data on the incidence of diagnosis, the case fatality rate in the diagnosed, and an assumption about how that rate varies with diagnosis to estimate the number of undiagnosed disease cases over the total number of disease cases (underdiagnosis) in each population group. We estimated underdiagnosis by year, sex, 10-year age group, relative deprivation, and administrative region. We then applied small-area estimation techniques to derive underdiagnosis estimates for health planning areas (CCGs).

Results
Levels of underdiagnosis varied between 16% for stroke and 69% for prostate cancer in 2018. For all diseases, the level of underdiagnosis declined over time. Underdiagnosis was not consistently concentrated in areas with high deprivation. For depression/anxiety and stroke, underdiagnosis was estimated to be higher in less deprived CCGs, whilst for CHD and T2DM, it was estimated to be higher in more deprived CCGs, with no apparent relationships for other conditions. We found no uniform spatial patterns of underdiagnosis across all diseases, and the relationship between age, deprivation and the probability of being undiagnosed varied greatly between diseases.

Discussion
Our findings suggest that underdiagnosis is not consistently concentrated in areas with high deprivation, nor is there a uniform spatial underdiagnosis pattern across diseases. This novel method for estimating the burden of underdiagnosis within England depends on the quality of routinely collected data, but it suggests that more research is needed to understand the key drivers of underdiagnosis.
A regularity result for incompressible elastodynamics equations in the ALE coordinates
Authors: Xie Binqiang 
Published: January 2025

Abstract
We consider incompressible inviscid elastodynamics equations with a free surface and establish regularity of solutions for these equations. Compared with previous result on this free boundary problem [X. Gu and F. Wang, Well-posedness of the free boundary problem in incompressible elastodynamic under the mixed type stability condition, J. Math. Anal. Appl., 482, (2020), 123529] in space H
3, we are able to establish regularity in space H
2.5+δ
upon the Arbitrary Lagrangian-Eulerian (ALE) coordinates. It is achieved by reformulating the system into a new formulation with the ALE coordinates, presenting uniform estimates for the pressure, tangential estimates for the system, as well as curl and divergence estimates.
Seismic response and damage model analysis of rocky slopes with weak interlayers
Authors: Zhao Yawen , Dong Jinyu , Liu Handong , Wang Chuang 
Published: January 2025

Abstract
A large-scale shaking table test of an anti-dip rock slope with a weak interlayer is conducted based on the Hongshiyan landslide induced by the Ludian earthquake. The dynamic failure mode energy damage identification method is analyzed using the Hilbert–Huang transformation and marginal spectrum theory. The result shows that the weak interlayer under horizontal loading amplifies the 5–10 and 25–30 Hz frequency signal and attenuates the 15–20 Hz signal. Within the hard rock, it amplifies the 5–15 Hz frequency signal and attenuates the 20–30 Hz signal. Under vertical loading, both weak interlayer and hard rock have an amplification effect on 5–30 Hz signal, and the amplification effect of weak interlayer is more significant. The horizontal seismic wave slope damage process can be divided into two stages: internal damage and obvious failure. When the horizontal seismic input amplitude reaches 0.2–0.3 g, internal damage occurs in the slope. The slope damage is primarily concentrated below two-third of the hard rock height and primarily in the shallow and surface regions of the slope. An input amplitude in the range of 0.4–0.5 g corresponds to the obvious failure stage. At this time, the slope first undergoes an obvious rupture in the rock above the weak layer; this rupture then extends upward to the top of the slope. Marginal spectral analysis results are consistent with the field model slope macroscopic rupture phenomenon.
Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
Authors: Mihajlović Filip , Andrić Ivana , Slović Živana , Vujović Maja , Piskulić Kristina , Đorđević Snežana 
Published: January 2025

Abstract

Introduction
Qualitative and quantitative testing of ethanol in post-mortem samples is an important analytical procedure that provides accurate, precise, and reliable results. Given the complexity of the issue, obtaining a realistic picture of lifelong alcoholemia requires supporting blood ethanol findings with analyses of alternative samples, primarily vitreous humor (VH).

Objective
The objective of this study was to develop and validate a headspace gas chromatography with flame ionization detection (HS/GC-FID) method for determining ethanol concentration in VH.

Materials and methods
Conditions for the HS/GC-FID method were established and the method was validated according to the guidelines of the European Medicines Agency. Validation parameters such as precision, accuracy, specificity, sensitivity, and linearity over a wide concentration range were evaluated through statistical analysis.

Results
The method demonstrated precision, accuracy, specificity, and sensitivity. Additionally, it proved to be linear across a wide concentration range and relatively fast, making it suitable for rapid and routine determination of ethanol concentration in VH, particularly for forensic applications.

Conclusion
Results from validation and application of the method to VH samples indicate that ethanol concentration in VH can be reliably determined using the presented HS/GC-FID method, making it a valuable tool in forensic investigations.
Effects of Movement Sonification Auditory Feedback on Repetitions and Brain Activity During the Bench Press
Authors: Garner Collin , Nachtegall Aubrey , Roth Edward , Sterenberg Alycia , Kim Daekyoo , Michael Timothy , Lee Sangwoo 
Published: January 2025

Abstract
Garner, C, Nachtegall, A, Roth, E, Sterenberg, A, Kim, D, Michael, T, and Lee, S. Effects of movement sonification auditory feedback on repetitions and brain activity during the bench press. J Strength Cond Res XX(X): 000–000, 2024—Auditory stimulation and feedback have been found to enhance aspects of motor performance such as motor learning, sense of agency, and movement execution. While music is the most common form of auditory stimulation during exercise, movement sonification (MoSo) may better facilitate motor performance through its use of music elements representing dynamic movements. Despite evidence of MoSo's benefits to motor performance, little is known about MoSo's influence on resistance exercise. The purpose of this research was to investigate the effects of MoSo auditory feedback on repetitions and brain activity during bench press. Twenty men performed bench press to failure in 3 sound conditions (no-sound, self-selected music, and MoSo). Repetition maximum (RM) was measured, and brain activity was analyzed using beta power spectral density (PSD) and frontal alpha asymmetry (FAA). A 1-way repeated measures analysis of variance (ANOVA) was conducted to compare data across sound conditions. To gain a deeper understanding of brain activity during bench press, a 2-way repeated measures ANOVA was performed to investigate changes in beta PSD and FAA over time using sound and timepoint as independent variables. A 1-way ANOVA showed that FAA in MoSo was significantly higher than in music and no-sound; however, no statistically significant differences were observed in RM and beta PSD between conditions. A 2-way ANOVA revealed that beta PSD and FAA increased significantly as bench press repetitions approached failure. Our study suggests that MoSo auditory feedback may not improve bench press repetitions, but it may increase brain activity during bench press better than listening to music.
Different External Cues Elicit Specific Kinetic Strategies During a Drop Jump in Well-Trained Adolescent Soccer Players
Authors: Barillas Saldiam R. , Lloyd Rhodri S. , Pedley Jason S. , Oliver Jon L. 
Published: January 2025

Abstract
Barillas, SR, Lloyd, RS, Pedley, JS, and Oliver, JL. Different external cues elicit specific kinetic strategies during a drop jump in well-trained adolescent soccer players. J Strength Cond Res XX(X): 000–000, 2024—The purpose of this study was to examine how different external cues that focus on jump height and ground contact time influence kinetic outcomes from a drop jump (DJ) in well-trained young soccer players. Following familiarization, 21 adolescent male soccer players performed 2 DJ trials under 4 different cue conditions: a height cue instructed subjects to jump to the ceiling, a ground contact cue instructed subjects to get off the ground as fast as possible, a combined condition joined both cues together, whereas a neutral cue with no external focus was used as a control condition. The height and contact time cues elicited specific kinetic responses that were significantly different to other conditions (p < 0.05); the height cue increasing impulses (d = 1.17–1.21) and jump height (d = 0.68), with the contact cue shortening ground contact time (GCT) (d = 1.27), increasing vertical stiffness (d = 1.48) and increasing force (d = 1.20–1.36). When combining the height and contact cue, a combination of significant (p < 0.05) kinetic responses were also observed, albeit to a lesser effect. Specifically, the combined cue increased impulse (d = 0.71–0.76) and jump height (d = 0.57) compared with a contact cue and a height cue, increased reactive strength index (d = 0.34), force (d = 0.69–0.83), and vertical stiffness (d = 0.75) while also reducing GCT (d = 0.69). Practitioners working with well-trained adolescent soccer players can use different external cues to effectively influence the kinetic strategies employed during a DJ.