bluuebunny/crossref_metadata_2025_split huggingface dataset:
Détente et loisirs en forêt – responsabilités et risques croissants
Authors: Pfund Jean-Laurent , Dirac Clémence , Schneider Olivier , Reinhard Michael 
Published: July 2023

Résumé
Les effets des changements climatiques sur les forêts inquiètent du point de vue sécuritaire, tant les propriétaires forestiers que les adeptes de détente et loisirs. Aujourd’hui réglées par des normes générales inscrites en particulier dans le Code des obligations, les responsabilités en cas d’accident liés à de tels effets se heurtent, dans le fond, à la question de la causalité et de la responsabilité du propriétaire. En fonction des évolutions politiques et réglementaires, certaines pistes de sécurisation juridique pourraient être intégrées dans des modifications du droit, telles que par exemple compléter l’art. 699 du Code civil. De plus, une clarification des devoirs d’entretien serait bienvenue, voire, en tant que piste théorique, la définition d’une responsabilité subsidiaire des autorités par rapport à des risques indépendants de l’entretien assuré par les propriétaires forestiers.
Dans l’intervalle, propriétaires forestiers, usagers et autorités peuvent formaliser des contrats ou conventions permettant de clarifier les responsabilités et limiter les risques pour chacun. Au-delà de tels arrangements volontaires, la prise en compte de la fonction d’accueil du public dans des zones prioritaires pourrait idéalement bénéficier d’un soutien et d’incitations semblables, par exemple, aux forêts jouant un rôle reconnu pour le maintien de la biodiversité. Il serait en effet imaginable de délimiter certaines zones et de soutenir de manière financière et technique des entretiens adaptés au maintien à long terme de cette fonction sociale, du point de vue sécuritaire comme du point de vue de l’attractivité du peuplement et des infrastructures pour les visiteurs.
STRATEGI PEMASARAN PRODUK UMRAH PADA TRAVEL SMARTS UMRAH LAMPUNG
Authors: Syamsiyah Nur 
Published: July 2023

This study uses the theory put forward by Kotler and Keller regarding the marketing mix, which is divided into the 7 Ps (product, promotion, price, place, people, process, and physical evidence), to discuss the marketing strategy for Umrah products at Travel Smart Umrah Lampung. This study aims to reveal the marketing strategy used by Travel Smarts Umrah to increase the number of pilgrims. This research is qualitative descriptive research, or field research, which uses primary and secondary data sources. The methods used to collect data are observation, interviews, and documentation. Based on the research conducted, Travel Smarts Umrah Lampung's marketing strategy to increase the number of pilgrims uses two methods: placing advertisements on all social media, going directly to prospective pilgrims, and distributing flyers through official Travel Smarts Umrah partners. In addition, through the ta'lim assembly, partnering with agencies, offering a bailout payment system, and prioritizing services for pilgrims.
Long-term effects of extractive and inclusive institutions on entrepreneurship persistence in Russian regions
Authors: Zemtsov S. P. , Tsareva Yu. V. 
Published: July 2023

Some institutions can restrict or stimulate the business activity, which affects long­term economic growth. To assess this influence on regional level, we have collected and processed historical data on the distribution of serfs, the creation of universities, and business activity over more than a century. By business activity, we mean various direct and indirect assessments of the involvement of the population in entrepreneurial activity: merchants, NEPmen, cooperatives, small businesses, etc. Although the geography of business activity has constantly changed, we can identify relatively stable centers (Moscow, St. Petersburg, the south of the Far Eastern Russia) and the periphery (some regions of the North Caucasus, the Central Black Earth and the Volga regions). Econometric calculations confirm the existence of a relationship between the current density of small businesses in the Russian regions and the density of cooperatives in the late Soviet period; the relationship with the density of retail enterprises disappears by the 1970s as the planned economy strengthens. But the relationship with the merchant class is ambiguous: only in some regions did the entrepreneurial culture manage to survive the Soviet period. We distinguish three main channels of influence of the historical level of business activity on the modern one: geographical, functional, and socio­cultural. According to the calculations, the earlier emergence of universities in the regions contributed to the spread of business culture and could stimulate the emergence of more inclusive institutions, but serfdom, as an extractive institution, on the contrary, could limit incentives for entrepreneurship. Even after a radical change in the political and economic regime, the influence of extractive institutions on business activity may persist, and inclusive institutions take a significant amount of time to take root.
SURVEY OF PUBLIC KNOWLEDGE ABOUT NEW NORMAL BEHAVIOR AFTER COVID-19
Authors: Juliasih Ni Njoman , Sari Renny Mareta , Setiyowati Eppy 
Published: July 2023

Introduction Coronavirus virus disease pandemic 2019 (Covid-19) has not shown improved health conditions, it is necessary to conduct an in-depth survey of public knowledge in carrying out healthy living behaviors after the Covid-19 pandemic. Clean and healthy living behavior is one of the efforts in maintaining personal and environmental hygiene. The purpose of the study was to conduct an analysis of public knowledge about clean and healthy living behaviors after the covid-19 pandemic.
Method Design used in qualitative research with explanatory survey approach. The technique of sampling snowballs over the internet online, an anonymous online instrument was developed using google form. Questionnaire links were sent via email, WhatsApp, and other social networks through researchers. The instrument packaged in structured questioner form (included as an additional file) consists of questions covering several fields: (1) sociodemographic data (age, gender and level of education), (2) New normal behavior habits include wearing a mask, washing hands with soap or hand sanitizer, social distancing, Do not a crowd with many people, keep the environment around the residence always clean and healthy, packaged in google form. Data recapitulation and processing are carried out with the help of IT, then qualitative analysis.
Research Results In this study, we conducted explorations related to sociodemographic, environmental hygiene around the place, healthy behavior habits including, wearing masks, hand washing, social distancing, availability of facilities for hand washing with hand sanitizer or hand washing with running water. The results showed that the community has carried out new normal behavior with awareness without any compulsion from anywhere. Thus new normal behavior includes, wearing masks, washing hands with running water or hand sanitizer and social distancing has become a new habit in order to break the chain of spread of 'covid 19.
Conclusion With a better understanding of the new normal behavior, people are able to break the indirect chain of transmission of COVID-19 in everyday life
Mazzig, Hen. The Wrong Kind of Jew: A Mizrahi Manifesto. Brentwood, TN: Wicked Son-Post Hill Press, 2022.
Authors: Margolin Elaine 
Published: July 2023

Review of Mazzig, Hen. The Wrong Kind of Jew: A Mizrahi Manifesto. Brentwood, TN: Wicked Son-Post Hill Press, 2022.
The role of short-chain fatty acids produced by gut microbiota in the regulation of pre-eclampsia onset
Authors: Cui Jinghan , Wang Jun , Wang Ying 
Published: July 2023

BackgroundPreeclampsia (PE) is a common pregnancy-related disorder characterized by disrupted maternal-fetal immune tolerance, involving diffuse inflammatory responses and vascular endothelial damage. Alterations in the gut microbiota (GM) during pregnancy can affect intestinal barrier function and immune balance.Aims and purposeThis comprehensive review aims to investigate the potential role of short-chain fatty acids (SCFAs), essential metabolites produced by the GM, in the development of PE. The purpose is to examine their impact on colonic peripheral regulatory T (Treg) cells, the pathogenic potential of antigen-specific helper T (Th) cells, and the inflammatory pathways associated with immune homeostasis.Key insightsAn increasing body of evidence suggests that dysbiosis in the GM can lead to alterations in SCFA levels, which may significantly contribute to the development of PE. SCFAs enhance the number and function of colonic Treg cells, mitigate the pathogenic potential of GM-specific Th cells, and inhibit inflammatory progression, thereby maintaining immune homeostasis. These insights highlight the potential significance of GM dysregulation and SCFAs produced by GM in the pathogenesis of PE. While the exact causes of PE remain elusive, and definitive clinical treatments are lacking, the GM and SCFAs present promising avenues for future clinical applications related to PE, offering a novel approach for prophylaxis and therapy.
Autoimmune thyroid disease disrupts immune homeostasis in the endometrium of unexplained infertility women—a single-cell RNA transcriptome study during the implantation window
Authors: Xie Jilai , Gu Aiyuan , He Huangyi , Zhao Qiaohang , Yu Ya , Chen Jian , Cheng Zhangliang , Zhou Ping , Zhou Qi , Jin Min 
Published: July 2023

ObjectiveAutoimmune thyroid disease (AITD) is known to be associated with unexplained infertility in women. Although the presence of antithyroid antibodies have been speculated to be a marker of an immune imbalance that might lead to implantation failure, its underlying mechanism influencing the endometrial receptivity remains to be elucidated. In this study, we used single-cell RNA sequencing (scRNA-seq) to dissect immune microenvironment in endometrium of AITD patients during window of implantation (WOI).MethodsWe collected CD45+ immune cell populations of endometrium samples of unexplained infertile women with AITD (n=3), as well as samples of AITD- controls (n=3). The cells were then processed with 10X Genomics Chromium for further analysis.ResultsWe characterized 28 distinct immune cell subtypes totally, and uncovered differences in the composition and gene expression patterns between AITD patients and controls. The proportions of T CD4+, cNK, ILC3, T CD8+GZMK+, T CD8+ Cytotoxic and ILC3 CD3E- cells were increased, and CD366+ uNK1 was decreased in AITD+ patients. And the abnormal expression of GNLY and chemokines was observed in AITD patients. In addition, uNK and T CD8+ Cytotoxic cells showed lower cytotoxicity but activation of immune response. Genes enriched in cell adhesion of ILC3 and Tregs were downregulated, while the number of ILC3 and Tregs were increased.ConclusionImmune imbalance exists in endometrium during WOI, which may impact embryo implantation.
Physiological and biochemical indicators in Norway spruces freshly infested by Ips typographus: potential for early detection methods
Authors: Stříbrská Barbora , Hradecký Jaromír , Čepl Jaroslav , Modlinger Roman , Tomášková Ivana , Jirošová Anna 
Published: July 2023

IntoductionThe bark beetle Ips typographus currently represents the primary pest of Norway spruce (Picea abies) in Central Europe. Early detection and timely salvage cutting of bark beetle-infested trees are functional management strategies for controlling bark beetle outbreaks. However, alternative detection methods are currently being developed, and possible indicators of bark beetle infestation can be assessed through changes in the physiological, biochemical, and beetle-acceptance characteristics of trees.MethodThis study monitored infested and non-infested Norway spruce trees before and 3 weeks after Ips typographus natural attack. Permanently installed sensors recorded physiological features, such as sap flow, tree stem increment, bark surface temperature, and soil water potential, to monitor water availability. Defensive metabolism characteristics, beetle host acceptance, and attractiveness to trees were monitored discretely several times per season. The forest stand that was later attacked by bark beetles had lower water availability during the 2018–2020 seasons compared to the non-attacked stands.ResultsAfter the attack, sap flow and tree stem increment were significantly lower in infested trees than in intact ones, and bark surface temperature moderately increased, even when measured in the inner forest stand from the shadowed side. Infested trees respond to attacks with a surge in monoterpene emissions. In addition, freshly infested trees were more accepted by males in the no-choice bioassays, and a significantly higher number of beetles were caught in passive traps in the first week of infestation.ConclusionThe most promising characteristics for early detection methods of bark beetle-infested trees include tree bark temperature measured only in certain meteorological conditions, elevated monoterpene emissions, and significantly high catches in passive traps.
Development of a radiomics nomogram to predict the treatment resistance of Chinese MPO-AAV patients with lung involvement: a two-center study
Authors: Chen Juan , Meng Ting , Xu Jia , Ooi Joshua D. , Eggenhuizen Peter J. , Liu Wenguang , Li Fang , Wu Xueqin , Sun Jian , Zhang Hao , Zhou Ya-Ou , Luo Hui , Xiao Xiangcheng , Pei Yigang , Li Wenzheng , Zhong Yong 
Published: July 2023

BackgroundPrevious studies from our group and other investigators have shown that lung involvement is one of the independent predictors for treatment resistance in patients with myeloperoxidase (MPO)–anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (MPO-AAV). However, it is unclear which image features of lung involvement can predict the therapeutic response in MPO-AAV patients, which is vital in decision-making for these patients. Our aim was to develop and validate a radiomics nomogram to predict treatment resistance of Chinese MPO-AAV patients based on low-dose multiple slices computed tomography (MSCT) of the involved lung with cohorts from two centers.MethodsA total of 151 MPO-AAV patients with lung involvement (MPO-AAV-LI) from two centers were enrolled. Two different models (Model 1: radiomics signature; Model 2: radiomics nomogram) were built based on the clinical and MSCT data to predict the treatment resistance of MPO-AAV with lung involvement in training and test cohorts. The performance of the models was assessed using the area under the curve (AUC). The better model was further validated. A nomogram was constructed and evaluated by DCA and calibration curves, which further tested in all enrolled data and compared with the other model.ResultsModel 2 had a higher predicting ability than Model 1 both in training (AUC: 0.948 vs. 0.824; p = 0.039) and test cohorts (AUC: 0.913 vs. 0.898; p = 0.043). As a better model, Model 2 obtained an excellent predictive performance (AUC: 0.929; 95% CI: 0.827–1.000) in the validation cohort. The DCA curve demonstrated that Model 2 was clinically feasible. The calibration curves of Model 2 closely aligned with the true treatment resistance rate in the training (p = 0.28) and test sets (p = 0.70). In addition, the predictive performance of Model 2 (AUC: 0.929; 95% CI: 0.875–0.964) was superior to Model 1 (AUC: 0.862; 95% CI: 0.796–0.913) and serum creatinine (AUC: 0.867; 95% CI: 0.802–0.917) in all patients (all p&lt; 0.05).ConclusionThe radiomics nomogram (Model 2) is a useful, non-invasive tool for predicting the treatment resistance of MPO-AAV patients with lung involvement, which might aid in individualizing treatment decisions.
Understanding a videogame home intervention for children with hemiplegia: a mixed methods multi-case study
Authors: Chan-Víquez Daniela , Khan Ajmal , Munce Sarah , Fehlings Darcy , Wright F. Virginia , Biddiss Elaine 
Published: July 2023

IntroductionAccess to rehabilitation therapies is a salient and growing issue for children with cerebral palsy (CP) and their families, motivating interest in home-based interventions. Bootle Blast is a low-cost, movement-tracking videogame that can be used at home to encourage upper limb (UL) functional exercise tailored to each child's abilities and therapy goals. The study objectives were to: 1) Establish the extent to which children achieve their self-directed play-time goal over a 12-week intervention, 2) Measure changes in UL motor outcomes, and 3) Explore participants' experiences of using Bootle Blast at home.MethodsMixed methods case series study of four children with hemiplegic cerebral palsy (HCP), each with a participating parent. Participants played Bootle Blast at home for 12 weeks. Study assessments occurred at baseline, post-intervention and four week follow up. A post-intervention interview explored participants' experiences. Game-logs provided play time and progress data.ResultsThree of four participants (8-13 yrs., Manual Ability Classification Level I-II) completed the intervention. One dropped out at week 6. Play-time goals were achieved in most weeks, with two of four children surpassing their overall intervention goals. Outcomes varied across the three participants, however consistent improvements were observed on the Canadian Occupational Performance Measure and the Box and Blocks Test. Inductive analysis generated four main themes: 1) Intrinsic motivators fostered play engagement, 2) Virtual play for real-world gains, 3) Therapy on demand (at home), and 4) Shifting the onus from the parent to the game. Integration of qualitative and quantitative data was important for interpreting play patterns/usage and clinical outcomes.DiscussionThis mixed methods study describes a novel videogaming intervention designed for home-rehabilitation for children with HCP and provides preliminary evidence to guide future study design and research.Clinical Trial Registration[https://clinicaltrials.gov/ct2/show/NCT04009031?recrs=h&amp;cond=Cerebral+Palsy&amp;cntry=CA&amp;city=Toronto&amp;draw=2&amp;rank=1], identifier [NCT04009031].
Causal relationship between kidney stones and gut microbiota contributes to the gut-kidney axis: a two-sample Mendelian randomization study
Authors: Liu Minghui , Zhang Youjie , Wu Jian , Gao Meng , Zhu Zewu , Chen Hequn 
Published: July 2023

BackgroundGut microbiota, particularly Oxalobacter formigenes, has been previously reported to be associated with kidney stones. However, the conflicting results from both observational and intervention studies have created substantial uncertainty regarding the contribution of Oxalobacter formigenes to the formation of kidney stone.MethodsWe employed a two-sample MR analysis to investigate the causal relationship between gut microbiota and kidney stones using GWASs summary statistics obtained from the MiBioGen and FinnGen consortia. Moreover, we conducted a reserve MR analysis to assess the direction of the causal associations between gut microbiota and kidney stones. The inverse variance weighted (IVW) approach represents the primary method of Mendelian Randomization (MR) analysis.ResultsOur analyses do not yield supportive evidence for a causal link between the genus Oxalobacter (OR = 0.99, 95% CI: 0.90–1.09, p = 0.811) and the formation of kidney stones. The order Actinomycetales (OR = 0.79, 95% CI: 0.65–0.96, p = 0.020), family Actinomycetaceae (OR = 0.79, 95% CI: 0.65–0.96, p = 0.019), family Clostridiaceae 1 (OR = 0.80, 95% CI: 0.67–0.96, p = 0.015), genus Clostridiumsensustricto 1 (OR = 0.81, 95% CI: 0.67–0.98, p = 0.030) and genus Hungatella (OR = 0.86, 95% CI: 0.74–0.99, p = 0.040) had protective effects on kidney stones, and the genus Haemophilus (OR = 1.16, 95% CI: 1.01–1.33, p = 0.032), genus Ruminococcaceae (UCG010) (OR = 1.38, 95% CI: 1.04–1.84, p = 0.028), genus Subdoligranulum (OR = 1.27, 95% CI: 1.06–1.52, p = 0.009) were risk factors for kidney stones. Differential abundance analysis provide no evidence of a association between Oxalobacter formigenes and kidney stones, and showed genus Subdoligranulum were risk factors for kidney stones. Reverse MR analysis did not indicate any causal association of kidney stones on gut microbiota. No considerable heterogeneity of instrumental variables or horizontal pleiotropy was observed.ConclusionOur two-sample MR study did not find any causal relationship between genus Oxalobacter and kidney stones. The association between gut microbiota and kidney stones does not solely depend on the presence of genus Oxalobacter/Oxalobacter formigenes. A more integrated approach using multiple omics platforms is needed to better understand the pathogenesis of kidney stones in the context of complex gene–environment interactions over time.
High level of agreement in a fixed vs. live cell-based assay for antibodies to myelin oligodendrocyte glycoprotein in a real-world clinical laboratory setting
Authors: Smith Tammy L. , Haven Thomas R. , Zuromski Lauren M. , Luong Kyphuong , Clardy Stacey L. , Peterson Lisa K. 
Published: July 2023

IntroductionAs recognition of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease becomes more widespread, the importance of appropriately ordering and interpreting diagnostic testing for this antibody increases. Several assays are commercially available for MOG testing, and based on a few small studies with very few discrepant results, some have suggested that live cell-based assays (CBA) are superior to fixed CBA for clinical MOG antibody testing. We aimed to determine the real-world agreement between a fixed and live CBA for MOG using two of the most commonly available commercial testing platforms.MethodsWe compared paired clinical samples tested at two national clinical reference laboratories and determined the real-world agreement between the fixed CBA and live CBA.ResultsOf 322 paired samples tested on both platforms, 53 were positive and 246 were negative by both methodologies (agreement 92.9%, Cohen’s kappa 0.78, [0.69-0.86]). Spearman correlation coefficient was 0.80 (p &lt; 0.0001). Of the discrepant results, only 1 of 14 results positive by the live CBA had a titer greater than 1:100, and only 1 of 9 results positive by the fixed CBA had a titer of greater than 1:80. Lower titers on the fixed CBA correlate to higher titers on the live CBA.ConclusionOverall, there is excellent agreement between fixed and live CBA for MOG antibody testing in a real-world clinical laboratory setting. Clinicians should be aware of which method they use to assess any given patient, as titers are comparable, but not identical between the assays.