bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fulfilling the promise of applied developmental science: Is it time to reconsider our approach?
Authors: Holochwost Steven J. , Mills‐Koonce W. Roger , Brown Eleanor D. 
Published: January 2023

AbstractThe promise of applied developmental science is that we can use scientific methods to promote positive human development and improve the lives of children and families. However, the present political environment in the United States makes the creation of research‐informed federal policy difficult, even when the evidence supporting a given policy is unequivocal. In this essay, we hope to begin a conversation about how we, as applied developmental scientists, may modify our approach in order to best fulfill the promise of applied developmental science. To begin this conversation, we discuss the potential for establishing long‐term partnerships with smaller entities, including state and municipal governments and non‐governmental organizations to narrow the gap between what we know about children and families and the policies and programs that impact them. This ‘bottom‐up’ approach has a long lineage in applied developmental science, and is currently enjoying a renaissance through the burgeoning interest in researcher‐practitioner partnerships. Whether implicitly or explicitly, these partnerships often incorporate a systems perspective on children's development; here, we review why embracing a systems perspective may increase the likelihood of crafting policies and programs that can improve the lives of children and families.
Biodegradable and antithrombogenic chitosan/elastin blended polyurethane electrospun membrane for vascular tissue integration
Authors: Selvaras Thiviya , Alshamrani Somyah Ali , Gopal Rathosivan , Jaganathan Saravana Kumar , Sivalingam Sivakumar , Kadiman Suhaini , Saidin Syafiqah 
Published: January 2023

AbstractCurrent commercialized vascular membranes to treat coronary heart disease (CHD) such as Dacron and expanded polytetrafluoroethylene (ePTFE) have been associated with biodegradable and thrombogenic issues that limit tissue integration. In this study, biodegradable vascular membranes were fabricated in a structure of electrospun nanofibers composed of polyurethane (PU), chitosan (CS) and elastin (0.5%, 1.0%, and 1.5%). The physicochemical properties of the membranes were analyzed, followed by the conduction of several test analyses. The blending of CS and elastin has increased the fiber diameter, pore size and porosity percentage with the appearance of identical chemical groups. The wettability of PU membranes was enhanced up to 39.6%, demonstrating higher degradation following the incorporation of both natural polymers. The PU/CS/elastin electrospun membranes exhibited a controlled release of CS (Higuchi and first‐order mechanisms) and elastin (Higuchi and Korsmeyer‐Peppas mechanisms). Delayed blood clotting time was observed through both activated partial thromboplastin time (APTT) and partial thromboplastin time (PT) analyses where significantly delay of 26.8% APTT was recorded on the PU membranes blended with CS and elastin, in comparison with the PU membranes, supporting the membrane's antithrombogenic properties. Besides, these membranes produced a minimum of 2.6 ± 0.1 low hemolytic percentage, projecting its hemocompatibility to be used as vascular membrane.
Bmi‐1 Overexpression Improves Sarcopenia Induced by 1,25(OH)2D3 Deficiency and Downregulates GATA4‐Dependent Rela Transcription
Authors: Wang Qiuyi , Zhao Jingyu , Chen Haiyun , Zhou Jiawen , Chen Ao , Zhang Jin'ge , Wang Yue , Mao Zhiyuan , Wang Jiachen , Qiu Xuehan , Chen Yutong , Wang Rong , Zhang Yongjie , Miao Dengshun , Jin Jianliang 
Published: January 2023

AbstractSarcopenia increases with age, and an underlying mechanism needs to be determined to help with designing more effective treatments. This study aimed to determine whether 1,25(OH)2D3 deficiency could cause cellular senescence and a senescence‐associated secretory phenotype (SASP) in skeletal muscle cells to induce sarcopenia, whether GATA4 could be upregulated by 1,25(OH)2D3 deficiency to promote SASP, and whether Bmi‐1 reduces the expression of GATA4 and GATA4‐dependent SASP induced by 1,25(OH)2D3 deficiency in skeletal muscle cells. Bioinformatics analyses with RNA sequencing data in skeletal muscle from physiologically aged and young mice were conducted. Skeletal muscles from 2‐month‐old young and 2‐year‐old physiologically aged wild‐type (WT) mice and 8‐week‐old WT, Bmi‐1 mesenchymal transgene (Bmi‐1Tg), Cyp27b1 homozygous (Cyp27b1−/−), and Bmi‐1TgCyp27b1−/− mice were observed for grip strength, cell senescence, DNA damage, and NF‐κB‐mediated SASP signaling of skeletal muscle. We found that muscle‐derived Bmi‐1 and vitamin D receptor (VDR) decreased with physiological aging, and DNA damage and GATA4‐dependent SASP activation led to sarcopenia. Furthermore, 1,25(OH)2D3 deficiency promoted DNA damage‐induced GATA4 accumulation in muscles. GATA4 upregulated Rela at the region from −1448 to −1412 bp at the transcriptional level to cause NF‐κB‐dependent SASP for aggravating cell senescence and muscular dysfunction and sarcopenia. Bmi‐1 overexpression promoted the ubiquitination and degradation of GATA4 by binding RING1B, which prevented cell senescence, SASP, and dysfunctional muscle, and improved sarcopenia induced by 1,25(OH)2D3 deficiency. Thus, Bmi‐1 overexpression improves sarcopenia induced by 1,25(OH)2D3 deficiency, downregulates GATA4‐dependent Rela transcription, and sequentially inhibits GATA4‐dependent SASP in muscle cells. Therefore, Bmi‐1 overexpression could be used for translational gene therapy for the ubiquitination of GATA4 and prevention of sarcopenia. © 2023 American Society for Bone and Mineral Research (ASBMR).
Brand extension failure and parent brand penalty: The role of implicit theories
Authors: Jain Shailendra Pratap , Mathur Pragya , Isaac Mathew S. , Mao Huifang , Maheswaran Durairaj 
Published: January 2023

AbstractGiven that the vast majority of brand extensions fail, it is important to understand how extension failure influences consumer judgments of the parent brand that launched the extension. In the brand extension literature, there is a paucity of research on the role of consumer characteristics in influencing response to such failures. To fill this gap, the present research examines the impact of consumers' implicit theory orientation—their perspective on whether personality traits are malleable versus fixed—on the severity of negative feedback effects following extension failure. Seven studies show that entity theorists, who believe in the fixedness of personality traits, penalize parent brands more than incremental theorists, who endorse trait malleability. This brand penalty effect arises because as compared to incremental theorists, entity theorists are motivated to view brands as a cohesive group and therefore equate extension failure with the diminishment of the overarching parent brand. This effect is more likely when brand cohesiveness is low or ambiguous, but it is less likely when brand cohesiveness is high. Furthermore, while entity theorists are more likely to reduce brand evaluations after extension failure, the two groups do not differ in parent brand evaluations after extension success.
Machine learning‐driven blood transcriptome‐based discovery of SARS‐CoV‐2 specific severity biomarkers
Authors: Krishnamoorthy Pandikannan , Raj Athira S , Kumar Himanshu 
Published: January 2023

AbstractThe Coronavirus disease 2019 (COVID‐19) pandemic, caused by rapidly evolving variants of severe acute respiratory syndrome coronavirus (SARS‐CoV‐2), continues to be a global health threat. SARS‐CoV‐2 infection symptoms often intersect with other nonsevere respiratory infections, making early diagnosis challenging. There is an urgent need for early diagnostic and prognostic biomarkers to predict severity and reduce mortality when a sudden outbreak occurs. This study implemented a novel approach of integrating bioinformatics and machine learning algorithms over publicly available clinical COVID‐19 transcriptome data sets. The robust 7‐gene biomarker identified through this analysis can not only discriminate SARS‐CoV‐2 associated acute respiratory illness (ARI) from other types of ARIs but also can discriminate severe COVID‐19 patients from nonsevere COVID‐19 patients. Validation of the 7‐gene biomarker in an independent blood transcriptome data set of longitudinal analysis of COVID‐19 patients across various stages of the disease showed that the dysregulation of the identified biomarkers during severe disease is restored during recovery, showing their prognostic potential. The blood biomarkers identified in this study can serve as potential diagnostic candidates and help reduce COVID‐19‐associated mortality.
Persistent hypersomnia following repetitive mild experimental traumatic brain injury: Roles of chronic stress and sex differences
Authors: Portillo Edwin , Zi Xiaomei , Kim Yeonho , Tucker Laura B. , Fu Amanda , Miller Lauren A. , Valenzuela Krystal S. , Sullivan Genevieve M. , Gauff Amina K. , Yu Fengshan , Radomski Kryslaine L. , McCabe Joseph T. , Armstrong Regina C. 
Published: January 2023

AbstractTraumatic brain injury (TBI) is often more complicated than a single head injury. An extreme example of this point may be military service members who experience a spectrum of exposures over a prolonged period under stressful conditions. Understanding the effects of complex exposures can inform evaluation and care to prevent persistent symptoms. We designed a longitudinal series of non‐invasive procedures in adult mice to evaluate the effects of prolonged mild stress and head injury exposures. We assessed anxiety, depression, and sleep–wake dysfunction as symptoms that impact long‐term outcomes after mild TBI. Unpredictable chronic mild stress (UCMS) was generated from a varied sequence of environmental stressors distributed within each of 21 days. Subsequently, mice received a mild blast combined with closed‐head mild TBI on 5 days at 24‐h intervals. In males and females, UCMS induced anxiety without depressive behavior. A major finding was reproducible sleep–wake dysfunction through 6‐ to 12‐month time points in male mice that received UCMS with repetitive blast plus TBI events, or surprisingly after just UCMS alone. Specifically, male mice exhibited hypersomnia with increased sleep during the active/dark phase and fragmentation of longer wake bouts. Sleep–wake dysfunction was not found with TBI events alone, and hypersomnia was not found in females under any conditions. These results identify prolonged stress and sex differences as important considerations for sleep–wake dysfunction. Furthermore, this reproducible hypersomnia with impaired wakefulness is similar to the excessive daytime sleepiness reported in patients, including patients with TBI, which warrants further clinical screening, care, and treatment development.
Synthesizing cross‐design evidence and cross‐format data using network meta‐regression
Authors: Hamza Tasnim , Chalkou Konstantina , Pellegrini Fabio , Kuhle Jens , Benkert Pascal , Lorscheider Johannes , Zecca Chiara , Iglesias‐Urrutia Cynthia P. , Manca Andrea , Furukawa Toshi A. , Cipriani Andrea , Salanti Georgia 
Published: January 2023

AbstractIn network meta‐analysis (NMA), we synthesize all relevant evidence about health outcomes with competing treatments. The evidence may come from randomized clinical trials (RCT) or non‐randomized studies (NRS) as individual participant data (IPD) or as aggregate data (AD). We present a suite of Bayesian NMA and network meta‐regression (NMR) models allowing for cross‐design and cross‐format synthesis. The models integrate a three‐level hierarchical model for synthesizing IPD and AD into four approaches. The four approaches account for differences in the design and risk of bias (RoB) in the RCT and NRS evidence. These four approaches variously ignoring differences in RoB, using NRS to construct penalized treatment effect priors and bias‐adjustment models that control the contribution of information from high RoB studies in two different ways. We illustrate the methods in a network of three pharmacological interventions and placebo for patients with relapsing–remitting multiple sclerosis. The estimated relative treatment effects do not change much when we accounted for differences in design and RoB. Conducting network meta‐regression showed that intervention efficacy decreases with increasing participant age. We also re‐analysed a network of 431 RCT comparing 21 antidepressants, and we did not observe material changes in intervention efficacy when adjusting for studies' high RoB. We re‐analysed both case studies accounting for different study RoB. In summary, the described suite of NMA/NMR models enables the inclusion of all relevant evidence while incorporating information on the within‐study bias in both observational and experimental data and enabling estimation of individualized treatment effects through the inclusion of participant characteristics.
Frightened or familiarised? Permanent residents' and second‐home owners' risk perceptions of extreme weather events
Authors: Czarnecki Adam , Dacko Aneta , Dacko Mariusz , Skowera Barbara 
Published: January 2023

AbstractThe number and severity of extreme weather events have been increasing globally. Given the vulnerabilities of second homes to natural disasters, it is important to learn how their owners consider the related risks. This paper investigates the extreme weather‐event risk perceptions and their preconditions between second‐home owners and local people in the Little Beskid mountains in Poland. The results show that, despite significant differences in social, demographic and presence–absence terms, the two populations were very similar with respect to risk perception. It then lays the ground for community preparedness and successful recovery from extreme weather hazards.
Evaluation of preservation protocols for oxygen‐sensitive minerals within laminated aquatic sediments
Authors: Ledesma Gabrielle , Islam Raisa , Swanner Elizabeth D. 
Published: January 2023

AbstractLaminated sediments can record seasonal changes in sedimentation of material from anoxic waters, including minerals of the redox‐sensitive elements Fe, Mn, and S that form under varying oxygen levels, mineral saturation conditions, and from microbial metabolism. However, preserving the oxygen‐sensitive minerals for identification is challenging when preservation of the spatial arrangement of laminae is also required. In this study, we compare methods for embedding sedimentary materials from anoxic waters and sediments from Brownie Lake, Minnesota, USA for analysis of the speciation for Fe, Mn, and S using synchrotron‐based X‐ray absorption near edge spectroscopy (XANES). We found that acetone dehydration and resin replacement in a 100% N2glovebox successfully preserved the speciation of Fe and Mn minerals within laminated sediments. However, acetone removed some sulfur species from sediments, and epoxies contained sulfur species, which challenged identification of native sulfur species. Results from this study will aid researchers who are interested in spatial analysis of oxygen sensitive sediments, soils, or microbial mats in choosing a preservation method.
Rough hypoellipticity for the heat equation in Dirichlet spaces
Authors: Hou Qi , Saloff‐Coste Laurent 
Published: January 2023

AbstractThis paper aims at proving the local boundedness and continuity of solutions of the heat equation in the context of Dirichlet spaces under some rather weak additional assumptions. We consider symmetric local regular Dirichlet forms, which satisfy mild assumptions concerning (1) the existence of cut‐off functions, (2) a local ultracontractivity hypothesis, and (3) a weak off‐diagonal upper bound. In this setting, local weak solutions of the heat equation, and their time derivatives, are shown to be locally bounded; they are further locally continuous, if the semigroup admits a locally continuous density function. Applications of the results are provided including discussions on the existence of locally bounded heat kernel; structure results for ancient (local weak) solutions of the heat equation.
Strata ofp‐origamis
Authors: Flake Johannes , Thevis Andrea 
Published: January 2023

AbstractGiven a two‐generated group of prime‐power order, we investigate the singularities of origamis whose deck group acts transitively and is isomorphic to the given group. Geometric and group‐theoretic ideas are used to classify the possible strata, depending on the prime‐power order. We then show that for many interesting known families of two‐generated groups of prime‐power order, including all regular, or powerful ones, or those of maximal class, each group admits only one possible stratum. However, we also construct examples of two‐generated groups of prime‐power order, which do not determine a unique stratum.
Comprehensive characterization and building of National Registry of von Hippel–Lindau disease in Brazil
Authors: Dallagnol Tabatha Nakakogue , Da Cás Eduardo , Junior Odery Ramos , Casali‐da‐Rocha José Cláudio 
Published: January 2023

BackgroundVon Hippel‐Lindau (VHL) disease is an autosomal dominant disorder caused by pathogenic variants in VHL gene. The common manifestations include hemangioblastomas (HB) of the central nervous system (CNS) and retina (RH); pheochromocytoma (PHEO); clear cell renal cell carcinoma (ccRCC); pancreatic and renal cysts (PRC) and pancreatic neuroendocrine neoplasm (PNEN).MethodsThe first characterization of VHL in Brazil was published in 2003 and included 20 families with a history of VHL. The aim of this study was to expand the previous Brazilian cohort to include more families, as well as to collect prospectively both clinical and molecular characteristics of patients with VHL to build the VHL Brazilian Registry (VHLBR). Patients with VHL were selected through review of data from medical records of experts and from social networks of support for families with VHL in Brazil.ResultsA total of 142 subjects representing 62 unrelated Brazilian families with VHL were registered. The mean age of VHL onset was 28.78 years old and 128 individuals (90.1%) had at least one VHL‐related lesion. CNS HB was the most common manifestation occurring in 91 (71%) patients, followed by multiple PRC (48.4%), RH (39.8%), ccRCC (28.9%), PHEO (12.5%) and PNEN (7.8%). Of the 97 subjects whose presence of VHL variants was confirmed, 51 (52.6%) had missense variants, 22 (22.7%) large deletions, 10 (10.3%) frameshift, 7 (7.2%) splice site, 4 (4.1%) nonsense and 3 (3.1%) in‐frame deletions. Regarding surveillance, 115 (81%) participants had at least one physician responsible for their outpatient follow‐up; however, 69 (60%) of them did not report a regular frequency of tests.ConclusionWe built the largest prospective VHLBR with organized collections of clinical and genetic data from families with VHL, which will be helpful to guide policies for VHL care and oncogenetics in Brazil. Although there have been improvements in diagnosis and clinical screening methods, VHL care in Brazil is still deficient, especially regarding surveillance and regular medical appointments with experts.
Lp error estimate of nonlinear Schrödinger equation using a two‐grid finite element method
Authors: Hu Hanzhang 
Published: January 2023

AbstractA two‐grid finite element scheme is presented for nonlinear Schrödinger equation. superconvergence error estimates of finite element solutions based on bound of finite element solutions is proved. The optimal order error estimations of the two‐grid solution in the and norm are given without any time‐step size conditions. It is shown, both theoretically and numerically, that the coarse space can be extremely coarse, with no loss in the order of accuracy.
A novel local Hermite radial basis function‐based differential quadrature method for solving two‐dimensional variable‐order time fractional advection–diffusion equation with Neumann boundary conditions
Authors: Liu Jianming , Li Xin Kai , Hu Xiuling 
Published: January 2023

AbstractA novel Hermite radial basis function‐based differential quadrature (H‐RBF‐DQ) method is presented in this paper based on 2D variable order time fractional advection–diffusion equations with Neumann boundary conditions. The proposed method is designed to treat accurately for derivative boundary conditions, which considerably improve the approximation results and extend the range of applicability for the method of RBF‐DQ. The advantage of the present method is that the Hermite interpolation coefficients are only dependent of the point distribution yielding a substantially better imposition of boundary conditions, even for time evolution. The proposed algorithm is thoroughly validated and is demonstrated to handle the fractional calculus problems with both Dirichlet and Neumann boundaries very well.
Tumor region associated with specific processing speed outcomes
Authors: Peterson Rachel K. , Ng Rowena , Ludwig Natasha N. , Jacobson Lisa A. 
Published: January 2023

AbstractObjectiveProcessing speed (PS) is a vulnerable cognitive skill in pediatric cancer survivors as a consequence of treatments and, less consistently, tumor region. Studies conventionally examine graphomotor PS; emerging research suggests other aspects of PS may be impacted. This study examined types of PS in pediatric brain tumor survivors to determine which aspects are impaired. Given discordance across studies, we additionally investigated the relationship between brain region and PS.MethodsThe sample consisted of 167 pediatric brain tumor patients (100 supratentorial). PS (oral naming, semantic fluency, phonemic fluency, motor speed, graphomotor speed, visual scanning) was gathered via clinical neuropsychological assessment. To examine PS by region, infratentorial and supratentorial groups were matched on age at diagnosis and neuropsychological assessment, and time since diagnosis.ResultsThe whole sample performed below normative means on measures of oral naming (p < .001), phonemic fluency (p < .001), motor speed (p = .03), visual scanning (p < .001), and graphomotor speed (p < .001). Only oral naming differed by region (p = .03), with infratentorial tumors associated with slower performance. After controlling for known medical and demographic risk factors, brain region remained a significant predictor of performance (p = .04). Among the whole sample, greater than expected proportions of patients with impairment (i.e., >1 standard deviation below the normative mean) were seen across all PS measures. Infratentorial tumors had higher rates of impairments across all PS measures except phonemic fluency.ConclusionsResults indicate pediatric brain tumor survivors demonstrate weaknesses in multiple aspects of PS, suggesting impairments are not secondary to peripheral motor slowing alone. Additionally, tumor region may predict some but not all neuropsychological outcomes in this population.
Design and characterization of multijunction photovoltaic laser power converters for nonuniform irradiance light profiles
Authors: Delgado Marina , García Iván , Hinojosa Manuel , Algora Carlos 
Published: January 2023

AbstractNonuniform irradiance profiles of lasers used in power‐by‐light systems deteriorate the efficiency of photovoltaic laser power converters. We analyze three approaches to deal with this efficiency loss: (1) to design the power converter front grid for the nonuniform light received from the power‐by‐light system; (2) to strengthen the peak current and decrease the series resistance of tunnel junctions; and (3) to homogenize the light spot impinging the power converter by simply distancing it from the laser fiber. In the context of these approaches, this paper tackles the optimization of multijunction photovoltaic laser power converters to achieve their maximum efficiency under nonuniform irradiance profiles, without using any optical element to homogenize them and, this way, reproducing realistic operating conditions. As a direct application of the design shown in this paper, we have increased the experimental efficiency of our GaAs devices by up to 3% absolute for a nominal laser wavelength of 857 nm.