bluuebunny/crossref_metadata_2025_split huggingface dataset:
Juvenile colon cancer diagnosed by onset of intussusception: a case report suggestive of Lynch syndrome treated with laparoscopic colectomy
Authors: Ogata Ryosuke , Fujii Toshiyuki , Hino Keisuke , Tsunedomi Ryouichi , Nagano Hiroaki , Ishihara Tokuhiro , Kamei Toshiaki , Nagasaka Takeshi , Nagahiro Yosuke , Yoshida Kazuya , Ikeda Akihiko , Hashiyada Hiroshi , Nakamoto Kenbu , Kajiyama Mika , Yamashita Aogu , Inoue Motoshige , Okita Kiwamu , Hazama Shoichi 
Published: March 2023

Abstract
Background: One characteristic of Lynch syndrome, which is caused by germline mutations in a group of genes encoding mismatch repair proteins, is the early onset of colorectal cancer. Here, we report a rare case of juvenile colon cancer, diagnosed based on the onset of intussusception with high microsatellite instability (MSI) and the absence of BRAF mutations, which was suggestive of Lynch syndrome.
Case presentation: A 28-year-oldman presented with right lower abdominal pain for approximately 3 months and defecated blacky stool for several weeks. He visited our hospital because of increasingly intense right lower abdominal pain. Computed tomography revealed a contrast-enhanced tumor and lymph nodes with a crab-claw-like fitted image extending into the ascending colon. Colon endoscopy revealed a large submucosal tumor-like lesion with ulceration. Laparoscopy-assisted ileal resection with level 3 lymph node dissection was performed 3 days after the endoscopic reduction of the intussusception. The histological diagnosis was a poorly differentiated adenocarcinoma. Gene analysis of the resected tumor revealed high MSIand KRAS mutations, and the absence of BRAF mutations. Immunohistochemistry indicated the absence of MLH1 and PMS2 expression in tumors. Genetic analysis of peripheral blood and tumors revealed no pathological mutations in MLH1, MSH2, PMS2, or MSH6.
Conclusion
A rare case of Lynch-like syndrome was diagnosed with intussusception. MSI-high, wild-type BRAF, and the absence of MLH1 and PMS2 expression suggested Lynch syndrome. The absence of pathological mutations in germline and somatic genes suggests the possibility of MLH1 promoter methylation or MLH1 epimutation in the pathogenesis of this case.
Understanding fluoride adsorption from groundwater by alumina modified with alum using PHREEQC surface complexation model
Authors: Adu-Boahene Francis , Boakye Patrick , Agyemang Frank Ofori , Kanjua Jolly , Oduro‑Kwarteng Sampson 
Published: March 2023

Abstract

Fluoride is recognized as a vital ion for human and animal growth because of the critical role it plays in preventing skeletal and dental problems. However, when it is ingested at a higher concentration it can cause demineralization of teeth and bones resulting in fluorosis, therefore, the production of high-adsorptive capacity material which is also cost-effective is necessary for the treatment of fluorides. In this study, aluminium foil is valorised into alumina nanoparticles. The as-prepared alumina was modified with alum in two different ratios of 1:0.5 and 1:1 (alumina to alum w/w%) and later used as adsorbents for the removal of fluoride from groundwater. The adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), point of zero charge and X-ray diffraction (XRD). Different factors that influence the removal efficiency of fluorides such as pH, initial concentrations, contact time and adsorbent dosage were studied and optimized using a simulated fluoride solution. The optimum conditions obtained were used to test real groundwater. The static experiment conditions were used to calibrate the PHREEQC geochemical model which was later used to simulate the fluoride sorption onto the modified alumina at different conditions. PHREEQC was also coupled with parameter estimation software (PEST) to determine equilibrium constants for the surface reactions between the fluoride species and the adsorbent in a way that the simulations accurately reflect the outcomes of laboratory experiments. Isotherm studies were carried out on the adsorbents. Both Langmuir and Freundlich's non-linear models fitted well for the equilibrium data. However, with a higher coefficient of regression and low chi-square test values, the adsorption process was more of chemisorption on a monolayer surface. Kinetic studies were also carried out by using the non-linear equations from the pseudo-first-order and pseudo-second-order models. The pseudo-second-order model fitted well for the equilibrium data. The mechanism for the fluoride ion adsorption was also studied by the intraparticle (IP) diffusion model and was found that IP was not the rate-determining factor and therefore the most plausible mechanism for the sorption process was ion exchange or attraction of fluoride ions to the sorbent surface. The findings obtained from this research show that readily available waste could be valorised into a useful product that could be employed in the removal of fluoride from water samples, including groundwater, that may contain too much fluoride and pose a risk to the general public's health.
Trend Analysis Using Meteorological Data and Non-parametric Statistical Tests: A Case Study of Jodhpur, Rajasthan, India
Authors: Choudhary Surendra Singh , Saini Rashmi 
Published: March 2023

AbstractThis paper presents trend analysis and change point detection of time-series data of climatic rainfall and temperature data for more than one century (Year 1901–2017) for Jodhpur, Rajasthan, India. For detailed analysis, non-parametric test Mann-Kendall trend test (MK-test), Modified Mann-Kendall trend test (Modified MK test), and Modified Mann-Kendall trend test with pre-whitening (Modified MK-test PWMK), have been carried out for trend detection. In addition, Sen's Slope test has been performed to analyzed the magnitude of trend, whereas, Pettitt's test has been carried out to assess change point detection. Results indicated that Z-test of Mann-Kendall has shown overall positive trend in annual and all seasonal except winter season with respect to both the data i.e. Indian Meteorological Department (IMD) and the Climate Research Unit (CRU) data. Temperature analysis trends have shown a positive value for Z in yearly and all seasons, which indicated that there has been a general tendency toward rising temperatures. For annual and seasonal rainfall time series analysis, no shift has been observed; however, climatic variables have shifted for the past few years as a result of global changes in temperature and rainfall. Results revealed that trend assessment and shift point detection (annual and seasonal) rainfall was not more significantly changed at the 10% significant level. Three non-parametric statistical tests have shown that air temperature has increased at 10% significant level annually and on seasonal basis. Analysis of this study may be helpful to show the relationship among different parameters and determine the prediction of climatic data variables.
Investigating the Factor that Influences the Implementation of Virtual Reality for Science Learning
Authors: Sumardani Dadan , Lin Chih-Hung 
Published: March 2023

Abstract

Intensively developed virtual reality (VR) has great potential in education and can be reliably integrated into the classroom, fostering authenticity to facilitate the rapid developments in science. This research aims to investigate the factor that influence the implementation of VR and the correlation between each dimension of the technology acceptance model that can lead to intentions to use VR. The structural equation modeling is performed that was tested on participants of preservice teachers who performed simulated science explorations in the weightlessness concept. The results show that most participants believe that VR is useful in many educational contexts, including immersion, authentic learning, motivation, and engagement. Moreover, the predicted model has good explanatory power to predict intention to use VR in the classroom (R2 = 64.7%), influenced by usefulness, enjoyment, and absence of cybersickness. Educators and researchers should consider avoiding the 360-degree VR beyond the advantages of ease and economics, then adopt more comfortable and accessible graphics-based VR for implementation in the classroom, as well as the suitability of content for students to avoid any cybersickness.
Electromagnetically Induced Transparency Based on Spoof Localized Surface Plasmonic
Authors: Tong Jinye , Wang Yi , Xu Zhixia 
Published: March 2023

Abstract
In this paper, a pair of resonators to realize multiple electromagnetically induced transparency-like (EIT-like) transmission peaks operating in the microwave band is designed, where the symmetric double-ellipsoids (SDEs) and the spoof localized surface plasmons (spoof LSPs) are used as the bright and dark modes, respectively. In order to reveal the mechanism of multiple EIT-like, a simplified mechanical model consisting of multiple particles is derived to visualize the metamaterial. The simulation and measurement results are identical showing that the EIT-like metamaterial can produce three transparent EIT-like transmission peaks in the frequency range of 7 ~ 10 GHz. We next proposed a plasmonically induced transparency refractive index sensor working in the infrared regions and analyzed it by simulation to reveal the sensing potential of EIT-like metamaterial. In this sensor, the group delay is treated as a high-Q sensing parameter, which has broad applications in various surface sensing applications based on EIT-like metamaterials.
Association of LHCGR gene variant rs2293275 with the polycystic ovary syndrome risk: an updated meta-analysis
Authors: Ibrahim Mohanand A. , Almutairi Mikhlid H. , Almutairi Bader O. 
Published: March 2023

Abstract
Polycystic ovary syndrome (PCOS) is the most pervasive endocrinopathy among women of reproductive age and its etiopathogenesis is poorly understood. We aimed to evaluate the association of LHCGR polymorphic variant rs2293275 (p.Asn312Ser) with the PCOS risk. We performed a systematic literature survey and meta-analysis on 12 published studies containing rs2293275 and PCOS. Pooled odds ratio and confidence intervals were determined to evaluate the associations using STATA software. Bioinformatic analysis was also performed to evaluate the pathogenicity and conservation of LHCGR p.Asn312Ser. We analysed genotypic data from 2142 PCOS cases and 4464 controls from 12 independent studies. We did not find any cumulative association between the rs2293275 variant and the PCOS in the allelic model (G vs A: OR=1.30, 95%CI: 0.81 – 1.78, p>0.05) or genotypic dominant model (GG vs GA+AA: OR=1.08; 95%CI:0.65 – 1.51), with a fair heterogeneity among studies. The bioinformatic analysis revealed that the variant is highly frequent across different populations and the corresponding amino acid residue p.Asn312 is variable and unlikely to be pathogenic. The present meta-analysis indicated rs2293275 polymorphism of LHCGR gene may not modulate the risk of PCOS. More replicative studies are required to corroborate our findings.
Predictors of Willingness to Accept COVID-19 Vaccine Among Adult Clients Attending Bule Hora University Teaching Hospital,West Guji Southern Ethiopia
Authors: Huka Alo Edin , Alemeyehu Lami , Jara Dube , Ayele Angefa , Shifa Tofik 
Published: March 2023

Abstract

Background:Vaccines are effective and ultimate solution that can decrease the burden of Coronavirus disease-19 worldwide. However, poor knowledge and unwillingness to accept this vaccine are key barriers to manage the coronavirus disease-19 pandemic in different country including Ethiopia. The control of pandemic principal will depend on acceptance of coronavirus disease vaccine. Therefore, there is paucity of evidence on coronavirus disease vaccine acceptance in the study area. The current study was aimed to assess willingness to accept coronavirus disease-19 vaccine and associated factors among adult clients attending Bule Hora University Teaching Hospital, west Guji zone, southern Ethiopia.Methods:Institution based cross sectional study was conducted among 385 study participants which was selected by Systematic random sampling technique. Data was collected through observation and structured questionnaires from April 10 to May 30, 2022. The collected data was cleaned and entered into Epi data 3.1 software before being exported to SPSS 25 statistical software for analysis. Bi-variable and multi-variable binary logistic regression model was used to identify the predictors of coronavirus disease-19 vaccine acceptance. The strength of association was measured using AOR with 95% confidence interval and significance was declared at p- value < 0.05.Result: -Magnitude of willingness to accept coronavirus disease-19 vaccine was 67.5 % (95%Cl: 63 -72). Good knowledge (AOR= 2.07, (1.17-3.64), history of chronic disease (AOR= 2.59(1.4-4.78) government employee (AOR= 2.35(1.1-5), favorable attitude (AOR= 14.15(5.25-37.46) and good adherence (AOR=1.74(1.023-2.97) were factors that significantly associated with willingness to accept coronavirus disease-19 vaccine.Conclusion:Magnitude of willingness to accept coronavirus disease-19 vaccine was considerable and needs to be improved. Knowledge, attitude, chronic illness, adherence, and being government employee were factors that associated with willingness to accept coronavirus disease-19 vaccine. Community awareness, advocacy, social mobilization and health education should be given at different levels.
Minimizing the opportunity costs of carbon mitigation on farmland via restoration of salinized soils
Authors: Suganuma Hideki , Sakai Yuji , Takahashi Nobuhide , Egashira Yasuyuki , Utsugi Hajime , Sochacki Stanley J. , Harper Richard J. , Hamano Hiroyuki , Kawarasaki Satoko , Aikawa Shin-ichi , Kojima Toshinori , Yamada Koichi 
Published: March 2023

Abstract

Mass conversion of native vegetation to agricultural land-use triggered secondary salinity, a hydrological imbalance, which has damaged more than 1.75 million ha of farmland in south-western Australia. Various types of reforestation have been proposed and tested to restore the hydrological balance, however the economic returns from these cannot compete with existing farm practice and land-holders thus have a reluctance to adopt. An alternative approach has been to reforest abandoned saline areas with salinity and/or water-logging tolerant trees to avoid displacement of farming activities and to minimize opportunity costs.
We propose an improved evaluation methodology for saline site reforestation and in this paper test its feasibility. Three eucalypts species (Eucalyptus salubris, E. camaldulensis and E. sargentii) were planted adjacent to a salt scald in Wickepin, Western Australia, and their survival and growth were monitored under increasing soil salinity ranging from moderate (ECe: 400-800 mS m-1), high (800-1,600 mS m-1) or extreme (>1,600 mS m-1) with shallow (< 1 m depth) saline ground water (EC: 2,000-3,000 mS m-1). Survival and growth of E. sargentii and E. salubris in the saline discharge areas were comparable to those in the arable area, and reforestation by these species can thus avoid land competition and opportunity costs.
Factors that impact the persistence of women in STEM higher education: A systematic literature review
Authors: Joseph Jane 
Published: March 2023

Abstract

Around the world, nations are spending millions of dollars urging educators to implement measures to increase the retention of women in STEM education. Unfortunately, an aggressive response is elusive from the higher education sector for these desperate calls. Globally the percentage of women graduating in STEM has remained stagnant for the past decade, indicating the need for further investigation of strategies to retain women in STEM. This study aimed to investigate factors that impact the persistence of women in STEM higher education and identify strategies for improving their retention in STEM studies. This systematic literature review (SLR) using PRISMA guidelines identified five major categories of factors such as: sociocultural, psychological, supportive, environmental and pedagogical that could positively or negatively influence women’s persistence in STEM studies. The findings of the study indicate that knowledge of these factors can be utilised to create a fertile ground for women’s successful persistence in STEM education. Though several studies explored this topic and identified some of these factors discretely, this would be the first study to bring all these major factors together to build a powerful framework for retaining women in STEM studies. The study presents a framework, “A success model for retention of women in STEM higher education”, that recommends powerful retention strategies by incorporating these identified factors.
A Novel Recombinant Modified Vaccinia Ankara Virus expressing
Interleukin-13 Receptor α2 Antigen for Potential Cancer
Immunotherapy
Authors: Sato Yuki , Vatsan Ramjay , Joshi Bharat H. , Husain Syed R. , Puri Raj K. 
Published: March 2023

Background:
Genetically altered recombinant poxviruses hold great
therapeutic promise in animal models of cancer. Poxviruses can induce effective cellmediated
immune responses against tumor-associated antigens. Preventive and
therapeutic vaccination with a DNA vaccine expressing IL-13Rα2 can mediate partial
regression of established tumors in vivo, indicating that host immune responses against
IL-13Rα2 need further augmentation.

Objective:
The aim of the study is developing a recombinant modified vaccinia Ankara
(MVA) expressing IL-13Rα2 (rMVA-IL13Rα2) virus and study in vitro infectivity and
efficacy against IL-13Rα2 positive cell lines.

Methods:
We constructed a recombinant MVA expressing IL-13Rα2 and a green
fluorescent protein (GFP) reporter gene. Purified virus titration by infection of target cells
and immunostaining using anti-vaccinia and anti-IL-13Rα2 antibodies was used to
confirm the identity and purity of the rMVA-IL13Rα2.

Results:
Western Blot analysis confirmed the presence of IL-13Rα2 protein (~52 kDa).
Flow cytometric analysis of IL-13Rα2 negative T98G glioma cells when infected with
rMVA-IL13Rα2 virus demonstrated cell-surface expression of IL-13Rα2, indicating the
infectivity of the recombinant virus. Incubation of T98G-IL13Rα2 cells with varying
concentrations (0.1-100 ng/ml) of interleukin-13 fused to truncated Pseudomonas
exotoxin (IL13-PE) resulted in depletion of GFP+ fluorescence in T98G-IL13Rα2 cells.
IL13-PE (10-1000 ng/ml) at higher concentrations also inhibited the protein synthesis in
T98G-IL13Rα2 cells compared to cells infected with the control pLW44-MVA virus. IL13-
PE treatment of rMVA-IL13Rα2 infected chicken embryonic fibroblast and DF-1 cell line
reduced virus titer compared to untreated cells.

Conclusion:
rMVA-IL13Rα2 virus can successfully infect mammalian cells to express
IL-13Rα2 in a biologically active form on the surface of infected cells. To evaluate the
efficacy of rMVA-IL13Rα2, immunization studies are planned in murine tumor models.
Coronary Artery Aneurysms as a Cause of Acute Coronary Syndrome
Presentation - A Focused Review
Authors: Latif Azka , Tran Amy , Ahsan Junaid , Lateef Noman , Abusina Waiel , Kapoor Vikas , Ahsan Zoraiz , Ahmad Soban , Mirza Mohsin 
Published: March 2023

Abstract:
Coronary artery aneurysms (CAA) are defined as a dilation of a coronary vessel greater than 1.5 times the diameter of a local reference vessel. While CAAs tend to be incidental findings on imaging, they result in complications, such as thrombosis, embolization, ischemia, arrhythmias, and heart failure. Among symptomatic cases, chest pain has been the most common manifestation of CAAs. This necessitates an understanding of CAAs as a cause of acute coronary syndrome (ACS) presentation. However, due to the unclear pathophysiology of CAAs and their variable presentation complicated by similar ACS conditions, there is no clear strategy for CAA management. In this article, we will discuss the contribution of CAAs to ACS presentations and review the current management options for CAAs.
Potential of Herbal Extracts as Sunscreens and Antihyperpigmentation
Treatment
Authors: Kothapalli Lata , Bhosale Komal , Thomas Asha , Sawant Pooja 
Published: March 2023

Background:
Skin pigmentation is one of the most serious problems in the adult population
of all races. The underlying factors of skin pigmentation are excessive exposure to UV radiation, oxidative
stress, and other provocative causes that cause melasma, black spots, and post-inflammatory
hyperpigmentation. Hence, treating hyperpigmentation disorders is challenging.

Objective:
Skin pigmentation occurs as a process of melanin biosynthesis triggered by UV exposure.
Tyrosinase, an enzyme that catalyzes the rate-confining step in melanogenesis, if inhibited, can cause
skin hypopigmentation. This has evoked an interest in reviewing plant extracts/ phytoconstituents,
which can serve the purpose of sun protection and treat hyperpigmentation, ensuring skin glow for a
better quality of life.

Methods:
A literature search on Medline, PubMed, Embase, and Scopus databases was done using
various keywords like hyperpigmentation, melasma, skin-lightening agents, and sunscreen.

Results:
Sun protection products for canopy with photo-aging and skin pigmentation are recommended.
Tyrosinase inhibitors are first-line topical medicines available as single or combined topical formulations.
Hydroquinone, retinoids, corticosteroids, and kojic acid are clinically proven as exceptionally
powerful. However, the adverse effects reported with these small molecules largely impact skin
appearance, dermatitis, and exogenous ochronosis. Currently, there is a rising trend towards comfortable,
fascinating, and well-endured skin depigmenting agents from natural products that might be utilized
by a wide populace.

Conclusion:
This present study aimed at exploring plant and fruit extracts together with their active
ingredients as potential multitargeted anti-hyperpigmentation agents with sunscreen properties, tyrosinase
inhibition, and skin whitening effects.
COVID-19 Vaccination Program for Children: An Electronic Assessment
of Symptoms
Authors: Kumar Naman , Khora Arjun , Loomba Riya , Sharma Nikhil , Kumar Abhishek , Rana Ajay , Kamboj Rohit , Kamboj Sweta , Guarve Kumar , Guatam Surya Prakash 
Published: March 2023

Background:
The evolution of COVID-19 vaccinations, which are mostly seen as crucial
to curb the epidemic, is a result of remarkable and ground-breaking researches by scientists
around the world.

Objective:
The main goal of this study was to identify the significant adverse reactions of these
vaccines, specifically in Homo sapiens.

Methods:
In this research, a trial version of Qualtrics CoreXM software was used, and 18 questionnaires
were prototyped as part of an online survey that was done in the northern part of India.

Results:
The dataset included survey responses from 286 vaccinated (Corbevax) respondents' samples
detailing their demographics, daily activities, type of gastronomic preferences, and any prior
illnesses. The data were collected between March 24, 2022, and April 26, 2022. After analysis,
70.98% of respondents who took the first dose of the medication experienced side effects, while
50.62% of respondents who took the second dose of the medication stated the same. The major
side effects reported were injection site pain, fever, tiredness, body ache, headache, etc.

Conclusion:
After conducting a poll on children (aged 12-18) who had received the COVID-19 vaccination,
we concluded that immunizations rarely cause moderate side effects that are manageable.