bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily exposure to virtual nature reduces symptoms of anxiety in college students
Authors: Browning Matthew H. E. M. , Shin Seunguk , Drong Gabrielle , McAnirlin Olivia , Gagnon Ryan J. , Ranganathan Shyam , Sindelar Kailan , Hoptman David , Bratman Gregory N. , Yuan Shuai , Prabhu Vishnunarayan Girishan , Heller Wendy 
Published: January 2023

AbstractExposure to natural environments offers an array of mental health benefits. Virtual reality provides simulated experiences of being in nature when outdoor access is limited. Previous studies on virtual nature have focused mainly on single "doses" of virtual nature. The effects of repeated exposure remain poorly understood. Motivated by this gap, we studied the influence of a daily virtual nature intervention on symptoms of anxiety, depression, and an underlying cause of poor mental health: rumination. Forty college students (58% non-Hispanic White, median age = 19) were recruited from two U.S. universities and randomly assigned to the intervention or control group. Over several weeks, anxious arousal (panic) and anxious apprehension (worry) decreased with virtual nature exposure. Participants identifying as women, past VR users, experienced with the outdoors, and engaged with the beauty in nature benefited particularly strongly from virtual nature. Virtual nature did not help symptoms of anhedonic depression or rumination. Further research is necessary to distinguish when and for whom virtual nature interventions impact mental health outcomes.
SVCT2-GLUT1-mediated ascorbic acid transport pathway in rat dental pulp and its effects during wound healing
Authors: Ohkura Naoto , Yoshiba Kunihiko , Yoshiba Nagako , Edanami Naoki , Ohshima Hayato , Takenaka Shoji , Noiri Yuichiro 
Published: January 2023

AbstractAscorbic acid (AA; vitamin C) plays a crucial role in the biosynthesis and secretion of collagen to produce the organic matrix of hard tissues. Nevertheless, the detailed mechanism by which AA induces reparative dentinogenesis is still unknown. This study aimed to investigate the pathway and function of AA during wound healing in a rat pulpotomy model. Sodium-dependent vitamin C transporter (SVCT) 2 and glucose transporter (GLUT) 1 were detected in odontoblasts, endothelial cells, and nerve fibers in normal pulp tissues. SVCT2 and GLUT1 were also expressed in odontoblast-like cells in pulpotomized tissues of Wistar rats, and immunopositive cells of SVCT2 were significantly increased at 5 days after pulpotomy (p < 0.05). By contrast, osteogenic disorder Shionogi (ODS) rats, which cannot generate AA, also expressed SVCT2 and GLUT1 in normal and wound healing conditions. However, in ODS rats, when compared with the AA-addition group, the formation of dentin bridges in the AA-loss group was not evident, a layer of osteopontin was significantly increased beneath the wound surface (p < 0.05), and alpha smooth muscle actin at the odontoblast-like cells observed along this layer was significantly increased (p < 0.05), but not Nestin. Moreover, the amounts of type 1 collagen generated in the reparative dentin and beneath the wound healing site were significantly diminished (p < 0.05). Macrophages expressing CD68 and CD206 increased beneath the wound site. Hence, AA may be involved in odontoblast-like cell differentiation and anti-inflammatory response during dental pulp wound healing. Our results provide new insights into the function of AA through SVCT2 and GLUT1 in reparative dentinogenesis and may help in developing new therapeutic targets for dental pulpal disease.
Phase II study comparing nasal pressure monitoring with capnography during invasive endoscopic procedures: a single-center, single-arm trial
Authors: Nagashima Hiroki , Mikata Rintaro , Isono Shiroh , Ogasawara Sadahisa , Sugiyama Harutoshi , Ohno Izumi , Yasui Shin , Matsumura Tomoaki , Koroki Keisuke , Kusakabe Yuko , Miura Yoshifumi , Kan Motoyasu , Maruta Shikiko , Yamada Toshihito , Takemura Ryo , Sato Yasunori , Kato Jun , Kato Naoya 
Published: January 2023

AbstractNasal pressure signal is commonly used to evaluate obstructive sleep apnea. This study aimed to assess its safety for respiratory monitoring during sedation. A total of 45 adult patients undergoing sedation with propofol and fentanyl for invasive endoscopic procedures were enrolled. While both nasal pressure and capnograph signals were continuously recorded, only the nasal pressure signal was displayed. The primary outcome was the incidence of oxygen desaturation below 90%. The secondary outcomes were the ability to predict the desaturation and incidence of harmful events and false alarms, defined as an apnea waveform lasting more than 3 min without desaturation. Of the 45 participants, 43 completed the study. At least one desaturation event occurred in 12 patients (27.9%; 95% confidence interval 15.3–43.7%). In these 12 patients, more than half of the desaturation events were predictable in 9 patients by capnography and 11 patients by nasal pressure monitoring (p = 0.59). In the 43 patients, false alarms were detected in 7 patients with capnography and 11 patients with nasal pressure monitoring (p = 0.427). Harmful events unrelated to nasal pressure monitoring occurred in 2 patients. Nasal pressure monitoring is safe and possibly useful for respiratory monitoring despite false alarms during sedation.
Elucidating the toxicity mechanism of AFM2 and the protective role of quercetin in albino mice
Authors: Onur Muhammed , Yalçın Emine , Çavuşoğlu Kültiğin , Acar Ali 
Published: January 2023

AbstractAflatoxin M2(AFM2) is a type of mycotoxin detected in milk or dairy products from animals consuming contaminated feed. In this study, the toxicity mechanism of AFM2and the protective effects of quercetin were investigated in albino mice. For this purpose, the mice were divided into 6 groups and the groups were fed with quercetin and AFM2. The toxic effects of AFM2and the protective properties of quercetin were investigated using physiological, biochemical and cytogenetic parameters. The genotoxic mechanism of AFM2and the protective role of quercetin were investigated by molecular docking, which is an in silico model. As a result, 16 mg/kg b.w AFM2administration caused serious changes in body weight, organ index, kidney and liver weight, and deterioration of antioxidant/oxidant balance in liver and kidney organs. The decrease in glutathione levels along with an increase in malondialdehyde (MDA) levels in the liver and kidney after AFM2administration indicates that oxidative stress is induced. The increases in alanine transaminase (ALT) and aspartat transaminase (AST) levels, which are indicators of liver damage, and the increases in serum levels of blood urea nitrogen (BUN) and creatinine, which are indicators of kidney damage, confirm the damage in both organs. AFM2also caused genotoxicity by inducing micronucleus (MN) and chromosomal abnormalities (CAs) in bone marrow tissue. It has been determined that AFM2, which exhibits genotoxicity as a result of its clastogenic and aneugenic effects, causes CAs by interacting with DNA. Quercetin provided significant protection by improving liver and kidney tissues, partial normalization in serum parameter levels, and severe reductions in MN and CAs. The highest protection was determined as 74.1% against dicentric chromosome formations in 50 mg/kg b.w quercetin application. The interaction of quercetin with xanthine oxidase and nitric oxide synthase enzymes was determined in silico with an inhibition constant in the range of 283.71–476.17 nM. These interactions cause changes in the activity of enzymes, reducing the oxidative load in the cell, and in this way, quercetin provides protection. All toxic effects induced by AFM2were decreased with quercetin administration dose-dependently, and this protective effect was associated with quercetin's reduction of oxidative load by inhibiting the free radical-producing enzyme. All toxic effects caused by AFM2were decreased with quercetin administration in a dose-dependent manner, and this protective effect was associated with quercetin's reduction of oxidative load by inhibiting the enzyme that produces free radicals.
Effect of gonadotropin-releasing hormone agonist monotherapy and combination therapy with growth hormone on final adult height in girls with central precocious puberty
Authors: Cho Ah Young , Shim Young Suk , Lee Hae Sang , Hwang Jin Soon 
Published: January 2023

AbstractThis study aimed to compare clinical parameters, including final adult height (FAH), in girls with central precocious puberty treated with gonadotropin-releasing hormone agonists (GnRHa) with and without growth hormone (GH). This retrospective study reviewed data of 210 girls with precocious puberty who had reached FAH in a long-term trial of GnRHa treatment. The subjects were divided into the GnRHa treatment group (n = 188), and the combined GnRHa + GH treatment group (n = 22). Chronological age, bone age, height, height standard deviation score, predicted adult height (PAH), FAH, Tanner stage, and hormone levels were assessed during the treatment period. At the start of treatment, PAH was 156.35 ± 6.34 cm in the GnRHa monotherapy group and 150.41 ± 5.32 cm in the GnRHa + GH group (P < 0.001). At the end of treatment, PAH was 166.25 ± 5.26 cm in the GnRHa group and 164.07 ± 4.99 cm in the combined GnRHa + GH treatment group, which had increased compared to the start of treatment. The FAH in the GnRHa group and GnRHa + GH combination group were 161.07 ± 4.78 cm and 159.63 ± 3.8 6 cm, respectively, without significant difference. In addition, the height gain (FAH–PAH) was significantly higher in the GnRHa + GH group than the GnRHa group (9.22 ± 6.03 cm vs. 4.72 ± 5.01 cm, P < 0.001). In girls with central precocious puberty, the height gain in the FAH compared to PAH at the start of treatment was significantly higher with the GnRHa + GH combination treatment.
Evolution of acquired resistance in a ROS1+ KRAS G12C+ NSCLC through the MAPK pathway
Authors: Priest Katherine , Le Anh , Gebregzabheir Amanuail , Nijmeh Hala , Reis Gregory B. , Mandell Melanie , Davies Kurtis D. , Lawrence Carolyn , O’Donnell Emily , Doebele Robert C. , Bao Liming , Aisner Dara L. , Schenk Erin L. 
Published: January 2023

AbstractPatients with metastatic NSCLC bearing a ROS1 gene fusion usually experience prolonged disease control with ROS1-targeting tyrosine kinase inhibitors (TKI), but significant clinical heterogeneity exists in part due to the presence of co-occurring genomic alterations. Here, we report on a patient with metastatic NSCLC with a concurrent ROS1 fusion and KRAS p.G12C mutation at diagnosis who experienced a short duration of disease control on entrectinib, a ROS1 TKI. At progression, the patient continued entrectinib and started sotorasib, a small molecule inhibitor of KRAS p.G12C. A patient-derived cell line generated at progression on entrectinib demonstrated improved TKI responsiveness when treated with entrectinib and sotorasib. Cell-line growth dependence on both ROS1 and KRAS p.G12C was further reflected in the distinct downstream signaling pathways activated by each driver. Clinical benefit was not observed with combined therapy of entrectinib and sotorasib possibly related to an evolving KRAS p.G12C amplification identified on repeated molecular testing. This case supports the need for broad molecular profiling in patients with metastatic NSCLC for potential therapeutic and prognostic information.
Urbanites’ mental health undermined by air pollution
Authors: Cao Zhi , Zhou Jingbo , Li Meng , Huang Jizhou , Dou Dejing 
Published: January 2023

AbstractThe rising mental health difficulties of the urban population in developing countries may be attributed to the high levels of air pollution. However, nationwide large-scale empirical works that examine this claim are rare. In this study, we construct a daily mental health metric using the volume of mental-health-related queries on the largest search engine in China, Baidu, to test this hypothesis. We find that air pollution causally undermines people’s mental health and that this impact becomes stronger as the duration of exposure to air pollution increases. Heterogeneity analyses reveal that men, middle-aged people and married people are more vulnerable to the impact of air pollution on mental health. More importantly, the results also demonstrate that the cumulative effects of air pollution on mental health are smaller for people living in cities with a higher gross domestic product per capita, more health resources, larger areas of green land and more sports facilities. Finally, we estimate that with a one-standard-deviation increase of fine particulate matter (26.3 μg m−3), the number of people who suffer from mental health problems in China increases by approximately 1.15 million. Our findings provide quantitative evidence for the benefits of reducing air pollution to promote mental health and well-being.
Uncertain future of sustainable fisheries environment in eastern boundary upwelling zones under climate change
Authors: Chang Ping , Xu Gaopeng , Kurian Jaison , Small R. Justin , Danabasoglu Gokhan , Yeager Stephen , Castruccio Frederic , Zhang Qiuying , Rosenbloom Nan , Chapman Piers 
Published: January 2023

AbstractUpwelling along ocean eastern boundaries is expected to intensify due to coastal wind strengthening driven by increasing land-sea contrast according to the Bakun hypothesis. Here, the latest high-resolution climate simulations that exhibit drastic improvements of upwelling processes reveal far more complex future upwelling changes. The Southern Hemisphere upwelling systems show a future strengthening in coastal winds with a rapid coastal warming, whereas the Northern Hemisphere coastal winds show a decrease with a comparable warming trend. The Bakun mechanism cannot explain these changes. Heat budget analysis indicates that temperature change in the upwelling region is not simply controlled by vertical Ekman upwelling, but also influenced by horizontal heat advection driven by strong near-coast wind stress curl that is neglected in the Bakun hypothesis and poorly represented by the low-resolution models in the Coupled Model Intercomparison Project. The high-resolution climate simulations also reveal a strong spatial variation in future upwelling changes, which is missing in the low-resolution simulations.
The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells
Authors: Küster Lukas , Paraschiakos Themistoklis , Karakurt Kader Ebru , Schumacher Udo , Diercks Björn-Philipp , Windhorst Sabine 
Published: January 2023

Abstract
Expression of Ins(1,4,5)P3-kinase-A (ITPKA), the neuronal isoform of Ins(1,4,5)P3-kinases, is up-regulated in many tumor types. In particular, in lung cancer cells this up-regulation is associated with bad prognosis and it has been shown that a high level of ITPKA increases migration and invasion of lung cancer cell lines. However, since ITPKA exhibits actin bundling and Ins(1,4,5)P3-kinase activity, it was not clear which of these activities account for ITPKA-promoted migration and invasion of cancer cells. To address this issue, we inhibited endogenous actin bundling activity of ITPKA in lung cancer H1299 cells by overexpressing the dominant negative mutant ITPKAL34P. Analysis of actin dynamics in filopodia as well as wound-healing migration revealed that ITPKAL34P inhibited both processes. Moreover, the formation of invasive protrusions into collagen I was strongly blocked in cells overexpressing ITPKAL34P. Furthermore, we found that ATP stimulation slightly but significantly (by 13%) increased migration of cells overexpressing ITPKA while under basal conditions up-regulation of ITPKA had no effect. In accordance with these results, overexpression of a catalytic inactive ITPKA mutant did not affect migration, and the Ins(1,4,5)P3-kinase-inhibitor GNF362 reversed the stimulating effect of ITPKA overexpression on migration. In summary, we demonstrate that under basal conditions the actin bundling activity controls ITPKA-facilitated migration and invasion and in presence of ATP the Ins(1,4,5)P3-kinase activity slightly enhances this effect.
Overlapping community‐based particle swarm optimization algorithm for influence maximization in social networks
Authors: Zhang Lei , Liu Yutong , Yang Haipeng , Cheng Fan , Liu Qi , Zhang Xingyi 
Published: January 2023

AbstractInfluence maximization, whose aim is to maximise the expected number of influenced nodes by selecting a seed set of k influential nodes from a social network, has many applications such as goods advertising and rumour suppression. Among the existing influence maximization methods, the community‐based ones can achieve a good balance between effectiveness and efficiency. However, this kind of algorithm usually utilise the network community structures by viewing each node as a non‐overlapping node. In fact, many nodes in social networks are overlapping ones, which play more important role in influence spreading. To this end, an overlapping community‐based particle swarm optimization algorithm named OCPSO for influence maximization in social networks, which can make full use of overlapping nodes, non‐overlapping nodes, and their interactive information is proposed. Specifically, an overlapping community detection algorithm is used to obtain the information of overlapping community structures, based on which three novel evolutionary strategies, such as initialisation, mutation, and local search are designed in OCPSO for better finding influential nodes. Experimental results in terms of influence spread and running time on nine real‐world social networks demonstrate that the proposed OCPSO is competitive and promising comparing to several state‐of‐the‐arts (e.g. CGA, CMA‐IM, CIM, CDH‐SHRINK, CNCG, and CFIN).
Uncertainties in asteroseismic grid-based estimates of the ages of halo stars
Authors: Moser S. , Valle G. , Dell’Omodarme M. , Degl’Innocenti S. , Prada Moroni P. G. 
Published: January 2023

Context. Stellar age determinations for field stars are crucial for studying the evolutionary history of the Galaxy. The vast majority of the research in this area has so far been focused on stars with typical disk characteristics.
Aims. Nowadays, the availability of high-quality asteroseismic data for stars with typical halo characteristics makes it possible to extend such investigations. The aim of this paper is to study the precision and theoretical biases in the age determinations of halo stars adopting both asteroseismic and classic observational constraints.
Methods. We adopt the well-tested SCEPtER pipeline, covering evolutionary phases up to the red giant branch (RGB). The fitting grids contain stars with mass in the range of [0.7; 1.0] M⊙ and metallicity [Fe/H] from −2.5 to −0.5, which are typical ranges seen in the halo population. We investigate several scenarios characterised by different adopted observational uncertainties. We also assess the impact of systematic discrepancies between the recovery grid models and target stars by computing several synthetic grids of stellar models with perturbed input physics.
Results. We achieve more precise asteroseismic age estimates for old metal-poor stars than for more metallic stars. In our reference scenario (errors in Δν and νmax of 2.5% and 5% respectively), we recover ages for stars in the main sequence (MS) or subgiant branch (SGB) with a typical 10%−20% precision, while we recover those of RGB stars with a precision of about 60%. However, recent observations allow tighter constraints on asteroseismic parameters by about a factor of 3. With this assumption, the age precision in RGB improved to 20%, while few modifications occur in the other analysed evolutionary phases. Our investigation of the relevance of systematic discrepancies between grid models and target stars shows that a mismatch in the mixing-length parameter value between grids and targets (from 1.9 to 1.74) leads to significant bias in the age estimations for MS stars (about 10%), but this bias is smaller for SGB and RGB stars. Neglecting the microscopic diffusion effect in the recovery grid leads to a typical 40% bias in age estimates for stars on the MS. Finally, we applied the age estimation technique to stars in globular clusters, adopting typical observational uncertainties from the literature. We find a precision in age estimates of around 20% for MS stars and up to 40% for RGB stars. These uncertainties are greater than those obtained with classical methods, which are therefore still to be preferred. We also applied the SCEPtER pipeline to the age determination of the stars of the cluster M4, relying on asteroseismic data for seven RGB stars from the literature. We obtain a cluster age of 11.9 ± 1.5 Gyr and a mass at the turn-of off 0.86 ± 0.04 M⊙, which are in good agreement with literature results.
HARPS-N high spectral resolution observations of Cepheids
Authors: Nardetto N. , Gieren W. , Storm J. , Hocdé V. , Pietrzyński G. , Kervella P. , Mérand A. , Gallenne A. , Graczyk D. , Pilecki B. , Poretti E. , Rainer M. , Zgirski B. , Wielgórski P. , Hajdu G. , Górski M. , Karczmarek P. , Narloch W. , Taormina M. 
Published: January 2023

Context. The Baade-Wesselink (BW) method of distance determination of Cepheids is used to calibrate the distance scale. Various versions of this method are mainly based on interferometry and/or the surface-brightness color relation (SBCR).
Aims. We quantify the impact of the SBCR, its slope, and its zero point on the projection factor. This quantity is used to convert the pulsation velocity into the radial velocity in the BW method. We also study the impact of extinction and of a potential circumstellar environment on the projection factor.
Methods. We analyzed HARPS-N spectra of η Aql to derive its radial velocity curve using different methods. We then applied the inverse BW method using various SBCRs in the literature in order to derive the BW projection factor.
Results. We find that the choice of the SBCR is critical: a scatter of about 8% is found in the projection factor for different SBCRs in the literature. The uncertainty on the coefficients of the SBCR affects the statistical precision of the projection factor only little (1–2%). Confirming previous studies, we find that the method with which the radial velocity curve is derived is also critical, with a potential difference on the projection factor of 9%. An increase of 0.1 in E(B − V) translates into a decrease in the projection factor of 3%. A 0.1 mag effect of a circumstellar envelope (CSE) in the visible domain is rather small on the projection factor, about 1.5%. However, we find that a 0.1 mag infrared excess in the K band due to a CSE can increase the projection factor by about 6%.
Conclusions. The impact of the surface-brightness color relation on the BW projection factor is found to be critical. Efforts should be devoted in the future to improve the SBCR of Cepheids empirically, but also theoretically, taking their CSE into account as well.