bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choosing more aggressive commitment contracts for others than for the self
Authors: Brimhall Craig I. , Tannenbaum David , VanEpps Eric M. 
Published: April 2023

Abstract
Commitment contracts are a strategy for binding self-control failures, such as skipping a gym visit or breaking a dieting regime, to monetary penalties. Despite evidence that commitment contracts with stronger penalties improve self-control, they are relatively underused. Across 5 experiments, we find that decision makers are less likely to select commitment contracts with more severe penalties (i.e., anti-charity contracts) for themselves than they are for others. This self-other difference in contract choice arises because decision makers believe anti-charity contracts will be more effective for others than for themselves. Our results suggest that people recognize the potential effectiveness of using more aggressive commitment contracts to overcome self-control problems, but view themselves as an exception to that general rule.
Deontological sceptical theism proved
Authors: Hendricks Perry 
Published: April 2023

AbstractIn this article, I argue that sceptical theists have too narrow a focus: they consider only God's axiological reasons, ignoring any non-axiological reasons he may have. But this is a mistake: predicting how God will act requires knowing about his reasons in general, and this requires knowing about both God's axiological and non-axiological reasons. In light of this, I construct and defend a kind of sceptical theism – Deontological Sceptical Theism – that encompasses all of God's reasons, and briefly illustrate how it renders irrelevant certain charges of excessive sceptical and how it evaporates equiprobability objections. Furthermore, I put forth a simple argument in favour of Deontological Sceptical Theism, which shows that everyone (at least currently) ought to endorse it.
The Promise and Pitfalls of Government Guidance Funds in China
Authors: Wei Yifan , Ang Yuen Yuen , Jia Nan 
Published: April 2023

AbstractIn 2005, the Chinese government deployed a new financial instrument to accelerate technological catch-up: government guidance funds (GGFs). These are funds established by central and local governments partnering with private venture capital to invest in state-selected priority sectors. GGFs promise to significantly broaden capital access for high-tech ventures that normally struggle to secure funding. The aggregate numbers are impressive: by 2021, there were more than 1,800 GGFs, with an estimated target capital size of US$1.52 trillion. In practice, however, there are notable gaps between policy ambition and outcomes. Our analysis finds that realized capital fell significantly short of targets, particularly in non-coastal regions, and only 26 per cent of GGFs had met their target capital size by 2021. Several factors account for this policy implementation gap: the lack of quality private-sector partners and ventures, leadership turnover and the inherent difficulties in evaluating the performance of GGFs.
Soil environmental DNA metabarcoding in low-biomass regions requires protocol optimization: a case study in Antarctica
Authors: Olmedo-Rojas Pamela , Jeunen Gert-Jan , Lamare Miles , Turnbull Johanna , Terauds Aleks , Gemmell Neil , Fraser Ceridwen I. 
Published: April 2023

AbstractEnvironmental DNA is a powerful tool for monitoring biodiversity. Although environmental DNA surveys have successfully been implemented in various environments, protocol choice has been shown to affect results and inferences. Thus far, few method comparison studies for soil have been undertaken. Here, we optimized the workflow for soil metabarcoding through a comparative study encompassing variation in sampling strategy (individual and combined samples), DNA extraction (PowerSoil®, NucleoSpin® Soil, PowerSoil® + phosphate buffer and NucleoSpin® Soil + phosphate buffer) and library preparation (one-step and two-step quantitative polymerase chain reaction methods). Using a partial 18S rRNA marker, a total of 309 eukaryotic taxa across 21 phyla were identified from Antarctic soil from one site in the Larsemann Hills. Our optimized workflow was effective with no notable reduction in data quality for a considerable increase in time and cost efficiency. The NucleoSpin® Soil + phosphate buffer was the best-performing extraction method. Compared to similar studies in other regions, we obtained low taxonomic coverage, perhaps because of the paucity of Antarctic terrestrial organisms in genetic reference databases. Our findings provide useful methodological insights for maximizing efficiency in soil metabarcoding studies in Antarctica and other low-biomass environments.
Antarctic science in Chile: a bibliometric analysis of scientific productivity during the 2009–2019 period
Authors: González-Aravena Marcelo , Krüger Lucas , Rebolledo Lorena , Jaña Ricardo , Aguayo-Lobo Anelio , Leppe Marcelo , Rondon Rodolfo , Santa-Cruz Francisco , Salinas Carla , Trevisan Cristine , Cárdenas César A. 
Published: April 2023

AbstractThe changes implemented in 2005 in the development strategies of Antarctic science carried out by Chile have had a positive impact on the scientific productivity of the Chilean Antarctic Science Program (PROCIEN). We analysed scientometric indicators from between 2009 and 2019. The bibliographic data were extracted from the Web of Science database using search query keywords. We used multiple correspondence analysis to identify specific trends and also network analyses of international collaboration in VOSviewer. The number of Antarctic science publications in Chile has gradually increased from 21 in 2009 to 95 in 2019. The rise in the number of articles was higher in journals for the first impact factor quartile. Research lines showing increased first-quartile impact factor papers corresponded to Antarctic ecosystems, biotechnology and geosciences. The main geographical domains in which such research activities have been carried out corresponded to in the South Shetland Islands and the Antarctic Peninsula. Fieldwork data are the main sources for the production of scientific articles, and there are three science platforms within which most of these papers concentrate. The diversification of funding sources, the implementation of improvements in the selection process and Chile's alignment with Scientific Committee on Antarctic Research programmes have contributed to improving the science that Chile has developed in Antarctica.
Holocene volcanic eruptions of the Malpaís de Zacapu and its pre-Hispanic settlement history
Authors: Reyes-Guzmán Nanci , Siebe Claus , Chevrel Magdalena Oryaëlle , Pereira Grégory , Mahgoub Ahmed Nasser , Böhnel Harald 
Published: April 2023

AbstractThe Michoacán-Guanajuato volcanic field (MGVF) hosts >1,400 monogenetic structures younger than 5 Ma. Here we focus on the Malpaís de Zacapu Late Holocene cluster located in the western part of the Zacapu lacustrine basin, situated in the heart of native Purepecha province. The Malpaís de Zacapu comprises four distinct eruptions: the Infiernillo lava flow emitted at ~1450 b.c.; Malpaís Las Víboras, a purely effusive eruption at ~1000 b.c.; the Capaxtiro compound lava flow at ~150 b.c.; and the most recent eruption, the Malpaís Prieto lava flow at ~a.d. 900. Although these lava flows are not inhabited today, they were densely populated in pre-Hispanic times (before a.d. 1521), especially during the Milpillas phase (a.d. 1200–1450). Volcanological studies (geochemical studies and detailed mapping using high-resolution DEM from LiDAR) allowed us to characterize these eruptions in terms of their magma source (rock chemical composition, mineral assemblage), age (radiocarbon and paleomagnetic dating), magnitude and dynamics (volume, morphology of the deposits), as well as lava flow emplacement duration. The findings allow us to infer the potential impact that these eruptions had on the pre-Hispanic settlement history of the area.
Nueva perspectiva sobre el sistema de organización territorial epiclásico en la región de Zacapu, Michoacán
Authors: Pereira Grégory , Dorison Antoine , Quezada Ramírez Osiris , Gillot Céline , Michelet Dominique 
Published: April 2023

ResumenEl período de aproximadamente tres siglos (600–900 d.C.), que corresponde al epiclásico, fue el escenario de una notable expansión de los asentamientos en la cuenca de Zacapu y sus alrededores. Si bien la zona parecía carecer de núcleos monumentales mayores equivalentes a los que se conocían en las regiones vecinas del Bajío o del sur de las tierras altas michoacanas, los trabajos recientes en la parte noroeste del Malpaís de Zacapu cambian esta concepción. Los datos proporcionados por medio del LiDAR y nuevos trabajos de campo revelaron complejos monumentales de dimensiones inéditas para la zona que estructuran una red de asentamientos menores distribuidos en un amplio territorio. Estos descubrimientos ofrecen nuevos datos sobre la arquitectura pública y doméstica de la época. La distribución de estos asentamientos y su relación con áreas dedicadas a la explotación de recursos agrícolas y mineros permiten vislumbrar un sistema más complejo e integrado, el cual pudo tener elementos comunes al de un altepetl. El objetivo de este artículo es presentar esta nueva información y reevaluar, a partir de ella, la organización territorial del período considerado.
Evaluation of dose calculation accuracy of a commercial radiotherapy treatment planning system for adjacent radiation fields
Authors: Rasouli Ali , Naraqi Arani Mahmud , Aliasgharzadeh Akbar , Farhood Bagher 
Published: April 2023

AbstractBackground:Adjacent radiation fields are applied in some radiotherapeutic cases. When using these radiation fields, considerable dose errors across the junction of radiation fields are possible. Therefore, it is necessary to evaluate the accuracy of the dose calculated by treatment planning system (TPS) when using the adjacent radiation fields. The present study aimed to quantify the dose calculation accuracy of ISOgray TPS for the photon-photon adjacent fields.Materials and methods:To assess the accuracy of dose calculations, the dose profiles were first measured by a Semiflex ionization chamber at 1, 1·5, 5 and 10 cm depths for different field sizes (6 × 6, 10 × 10 and 20 × 20 cm2), source to surface distances (SSDs) (90, 100 and 110 cm) and beam angles (0º, 15º, 30º and 45º). In the second step, the data at corresponding depths were extracted from the ISOgray TPS. Finally, the dosimetric performance of TPS was evaluated using a gamma index analysis.Results:The overall dose calculation accuracy of ISOgray TPS was within the acceptable range for the build-up region (with acceptance criteria of dose difference (DD) = 15% and distance to agreement (DTA) = 3 mm) and the depths after the build-up region (with acceptance criteria of DD = 5% and DTA = 3 mm). Moreover, the overall accuracy of dose calculations was not affected by the field size and the SSD. It was also shown that the accuracy of dose calculations was similar for the adjacent radiation fields with beam angles of 0º, 15 º and 30 º, while a considerable decrease in the pass rate values is obtained for the adjacent radiation field with 45 º beam angle. A more detailed analysis of the findings revealed that the accuracy of dose calculations in the match line regions of the adjacent radiation fields for 1 cm beam profiles was within the acceptable range; however, it declined for other depths.Conclusions:The findings showed that the overall dose calculation accuracy of ISOgray TPS was acceptable for evaluated adjacent radiation fields. However, the accuracy of dose calculations in the match line regions of the adjacent radiation fields for the depth after build-up was not within the acceptable range.
A survey inquiry into behavioral foundations of hate speech regulations: evidence from Japan
Authors: Hirose Kentaro , Kim Hae , Kohno Masaru 
Published: April 2023

AbstractThis paper highlights the concept of dignity as the cornerstone that justifies hate speech regulations in democratic societies. In political theory and constitutional law, the primacy of dignity as the moral and legislative justification for regulating hate speech has already been addressed by dignitarianism, especially in the course of debate with free speech advocates. We aim to augment this important claim in the normative literature with empirical data. Specifically, based on our survey conducted in Japan, where its first national anti-hate speech law had only recently been enacted and ordinary citizens were thus less predisposed of the debate, we show that citizens' concerns about the dignity of a targeted victim lead them to support regulations. Our analysis further clarifies the possible mechanisms of the dignitarian rationale, revealing not only the people's public-centered expectation regarding the societal consequences of hate speech, which dignitarians emphasized, but also the importance of more individual-based judgments regarding morality and justice, in shaping their regulatory attitudes.
Blood pressure surveillance in cancer patients treated with immune checkpoint inhibitors
Authors: Tan Sean , Spear Ella , Sane Nikhita , Nelson Adam J. , Nerlekar Nitesh , Segelov Eva , Nicholls Stephen J. 
Published: April 2023

AbstractImmune checkpoint inhibitors (ICI) are cancer therapies that have been associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). Blood pressure (BP) measurements are routinely performed during day oncology center visits for administration of ICI therapy but are often not assessed temporally to screen and monitor hypertension, which could independently increase the risk of ASCVD in cancer survivorship. This study reports the feasibility of using serial BP measurements from routine visits to day oncology center to diagnose and monitor hypertension control in cancer patients receiving ICIs.
Near-field terahertz nonlinear optics with blue light
Authors: Pizzuto Angela , Ma Pingchuan , Mittleman Daniel M. 
Published: April 2023

AbstractThe coupling of terahertz optical techniques to scattering-type scanning near-field microscopy (s-SNOM) has recently emerged as a valuable new paradigm for probing the properties of semiconductors and other materials on the nanoscale. Researchers have demonstrated a family of related techniques, including terahertz nanoscopy (elastic scattering, based on linear optics), time-resolved methods, and nanoscale terahertz emission spectroscopy. However, as with nearly all examples of s-SNOM since the technique’s inception in the mid-1990s, the wavelength of the optical source coupled to the near-field tip is long, usually at energies of 2.5 eV or less. Challenges in coupling of shorter wavelengths (i.e., blue light) to the nanotip has greatly inhibited the study of nanoscale phenomena in wide bandgap materials such as Si and GaN. Here, we describe the first experimental demonstration of s-SNOM using blue light. With femtosecond pulses at 410 nm, we generate terahertz pulses directly from bulk silicon, spatially resolved with nanoscale resolution, and show that these signals provide spectroscopic information that cannot be obtained using near-infrared excitation. We develop a new theoretical framework to account for this nonlinear interaction, which enables accurate extraction of material parameters. This work establishes a new realm of possibilities for the study of technologically relevant wide-bandgap materials using s-SNOM methods.
Reversal of the diabetic bone signature with anabolic therapies in mice
Authors: Marino Silvia , Akel Nisreen , Li Shenyang , Cregor Meloney , Jones Meghan , Perez Betiana , Troncoso Gaston , Meeks Jomeeka , Stewart Scott , Sato Amy Y. , Nookaew Intawat , Bellido Teresita 
Published: April 2023

AbstractThe mechanisms underlying the bone disease induced by diabetes are complex and not fully understood; and antiresorptive agents, the current standard of care, do not restore the weakened bone architecture. Herein, we reveal the diabetic bone signature in mice at the tissue, cell, and transcriptome levels and demonstrate that three FDA-approved bone-anabolic agents correct it. Diabetes decreased bone mineral density (BMD) and bone formation, damaged microarchitecture, increased porosity of cortical bone, and compromised bone strength. Teriparatide (PTH), abaloparatide (ABL), and romosozumab/anti-sclerostin antibody (Scl-Ab) all restored BMD and corrected the deteriorated bone architecture. Mechanistically, PTH and more potently ABL induced similar responses at the tissue and gene signature levels, increasing both formation and resorption with positive balance towards bone gain. In contrast, Scl-Ab increased formation but decreased resorption. All agents restored bone architecture, corrected cortical porosity, and improved mechanical properties of diabetic bone; and ABL and Scl-Ab increased toughness, a fracture resistance index. Remarkably, all agents increased bone strength over the healthy controls even in the presence of severe hyperglycemia. These findings demonstrate the therapeutic value of bone anabolic agents to treat diabetes-induced bone disease and suggest the need for revisiting the approaches for the treatment of bone fragility in diabetes.
Plasma metabolomic characterization of SARS-CoV-2 Omicron infection
Authors: Li Xue , Liu Yimeng , Xu Guiying , Xie Yi , Wang Ximo , Wu Junping , Chen Huaiyong 
Published: April 2023

AbstractOmicron variants of SARS-CoV-2 have spread rapidly worldwide; however, most infected patients have mild or no symptoms. This study aimed to understand the host response to Omicron infections by performing metabolomic profiling of plasma. We observed that Omicron infections triggered an inflammatory response and innate immune, and adaptive immunity was suppressed, including reduced T-cell response and immunoglobulin antibody production. Similar to the original SARS-CoV-2 strain circulating in 2019, the host developed an anti-inflammatory response and accelerated energy metabolism in response to Omicron infection. However, differential regulation of macrophage polarization and reduced neutrophil function has been observed in Omicron infections. Interferon-induced antiviral immunity was not as strong in Omicron infections as in the original SARS-CoV-2 infections. The host response to Omicron infections increased antioxidant capacity and liver detoxification more than in the original strain. Hence, these findings suggest that Omicron infections cause weaker inflammatory alterations and immune responses than the original SARS-CoV-2 strain.
Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1
Authors: Xu Dan-Hong , Du Jian-Kui , Liu Shi-Yu , Zhang Hui , Yang Lu , Zhu Xiao-Yan , Liu Yu-Jian 
Published: April 2023

AbstractNeuronal apoptosis has been well-recognized as a critical mediator in the pathogenesis of depressive disorders. Tissue kallikrein-related peptidase 8 (KLK8), a trypsin-like serine protease, has been implicated in the pathogenesis of several psychiatric disorders. The present study aimed to explore the potential function of KLK8 in hippocampal neuronal cell apoptosis associated with depressive disorders in rodent models of chronic unpredictable mild stress (CUMS)-induced depression. It was found that depression-like behavior in CUMS-induced mice was associated with hippocampal KLK8 upregulation. Transgenic overexpression of KLK8 exacerbated, whereas KLK8 deficiency attenuated CUMS-induced depression-like behaviors and hippocampal neuronal apoptosis. In HT22 murine hippocampal neuronal cells and primary hippocampal neurons, adenovirus-mediated overexpression of KLK8 (Ad-KLK8) was sufficient to induce neuron apoptosis. Mechanistically, it was identified that the neural cell adhesion molecule 1 (NCAM1) may associate with KLK8 in hippocampal neurons as KLK8 proteolytically cleaved the NCAM1 extracellular domain. Immunofluorescent staining exhibited decreased NCAM1 in hippocampal sections obtained from mice or rats exposed to CUMS. Transgenic overexpression of KLK8 exacerbated, whereas KLK8 deficiency largely prevented CUMS-induced loss of NCAM1 in the hippocampus. Both adenovirus-mediated overexpression of NCAM1 and NCAM1 mimetic peptide rescued KLK8-overexpressed neuron cells from apoptosis. Collectively, this study identified a new pro-apoptotic mechanism in the hippocampus during the pathogenesis of CUMS-induced depression via the upregulation of KLK8, and raised the possibility of KLK8 as a potential therapeutic target for depression.
Confusion around Certification of Vision Impairment (CVI) and registration processes—are patients falling through the cracks?
Authors: Pardhan Shahina , Driscoll Robin , Ingleton Hilary , Slade John , Bowen Michael , Lovell-Patel Rupal , Farrell Sarah , Bourne Rupert , Mahoney Simon , Ahluwalia Sanjiv , Trott Mike 
Published: April 2023

Abstract
Background
In the UK, the Certificate of Vision Impairment (CVI) certifies a person as sight impaired (partially sighted) or severely sight impaired (blind). This is completed by ophthalmologists and passed with the patient’s consent to their GP, their local authority, and The Royal College of Ophthalmologists Certifications office. Once a person is certified, they can be registered by their local authority which is voluntary but enables the person to access rehabilitation or habitation services, financial concessions, welfare benefits and other services provided by local authorities.

Methods
We conducted semi-structured individual interviews with 17 patients with a diagnosed eye condition, 4 Eye Clinic Liaison Officers (ECLO) and 4 referring optometrists around their experiences around CVI and registration processes. Analysis of themes was conducted with results synthesised in a narrative analysis.

Results
Patients reported lack of clarity around the processes of certification and registration, benefits of certification and what happens beyond certification, the type of support that they are entitled to, delays in accessing support. Optometrists appear not to engage with the process much, especially if the patient is being treated by the hospital eye service.

Conclusion
Vision loss can be a devastating experience for the patient. There is a lack of information and confusion around the process. The lack of a joined-up process between certification and registration needs to be addressed if we are to provide the support that patients deserve in order to improve their quality of life and wellbeing.