bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrategias metodológicas activas para desarrollar el pensamiento crítico en estudiantes de secundaria de EBR
Authors: Ojose Machuca Mag. Mónica Candy 
Published: January 2023

Las estrategias metodológicas son las técnicas que permiten construir el aprendizaje de los estudiantes la cual debe ser propuesta adecuadamente por el docente con la finalidad de promover a desarrollar el pensamiento crítico reflexivo, encaminadas a las soluciones de situaciones complejas y toma de decisiones autónomas en cada uno los alumnos. El presente articulo científico tiene como objetivo determinar el efecto que ejerce las estrategias metodológicas activas de aprendizaje en el desarrollo del pensamiento crítico en los estudiantes de zonas urbanas y rurales del nivel secundario de EBR , el método de investigación utilizado es el científico de tipo longitudinal, de nivel explicativo y diseño pre experimental con una muestra seleccionada de 25 estudiantes de zona urbana y 25 estudiantes de zona rural del tercer grado de educación secundaria ,se aplicó una prueba de entrada para determinar el nivel del pensamiento crítico de los estudiantes posteriormente a ello se desarrolló sesiones de aprendizaje , en la que se consideró las metodologías activas como la elaboración de un ensayo, desarrollo de cuestionarios ,socio drama, árbol de problemas, elaboración de textos argumentativos, estudio de casos ,debates ,elaboración de historietas, organizadores(cuadro comparativo, mapa mental ,espina de Ishikawa). Posterior a ello se llevó a cabo la evaluación de salida, la interpretación de los resultados se realizó teniendo en cuenta la estadística descriptiva mediante tablas, los datos cumplen con los criterios de distribución normal y homogeneidad de varianza. Los resultados determinan que si existe diferencia significativa (p=0.00)en el pensamiento crítico (prueba de entrada y salida ,mediante las estrategias metodológicas activas en los estudiantes de tercer grado del nivel secundario de EBR, con un aumento de 20 puntos entre la evaluación de entrada y la evaluación de salida en estudiantes de zona urbana y 18 punto de aumento entre la evaluación de entrada y salida de los estudiantes de la zona rural , por lo que se concluye lo siguiente: las estrategias metodológicas activas de aprendizaje aplicadas en el desarrollo de las sesiones de aprendizaje en los estudiantes de tercer grado del nivel secundaria de EBR si influyen significativamente en el desarrollo del pensamiento crítico
Sistema inteligente para la detección del SARS CoV-2
Authors: Yibale Toledo Jahzeel Andre , Soto Hernández Brenda Nataly , Kevin Fernando Arrieta Lozano Kevin Fernando , Castillo Ortiz Sindya Yadira , Flores Cabrera Julio Cesar 
Published: January 2023

Actualmente se vivió una pandemia que sorprendió a todos, no se tenía forma de controlar al personal que lograba ingresar a instituciones, centros comerciales, hospitales, etc. Para lograr controlar el acceso de las personas y así evitar contagios masivos del virus, entre otras situaciones que se percataron en ese entonces. Debido a esa problemática surgida, se dio la idea de implementar un sistema que ayude a tener un control del acceso de las personas y con ayuda de un manejador de base de datos se guarde su información y los resultados que arroje al cuestionario que se desea aplica en esta aplicación, para así dar un resultado aproximado de la probabilidad que pueda tener un contagio o no del virus, y para ser más certero, que el encargado del acceso pueda tener manejo de los resultados y toman en cuenta el resultado que arroje la aplicación para dar acceso dependiendo de lo que marque la encuesta.
El presente trabajo tiene como principal objetivo el desarrollo de una aplicación móvil para prevenir el contagio por el virus "SARS-CoV-2" dentro del Instituto Tecnológico de Iguala. En el cual en la APP se pondrán mediante un cuestionario los síntomas del presente virus y los usuarios puedan responder cuál de los síntomas que han tenido y mediante sus respuestas determinar si es seguro su ingreso a la institución o no, al momento de ingresar el código QR que arroja al final de la encuesta y que guarda sus datos, esto lo hace más fácil de utilizar y más ágil. Además de agregar una adaptación para que sea utilizado en más pandemias posteriores, ya que esta pandemia (Covid19) no es el primer caso en el mundo que se logre dar a conocer, por eso tiene la función de ser implementada y adaptada para otros momentos, con otros posibles casos.
Adult Onset Langerhans Cell Histiocytosis: A Single Center Experience
Authors: ÇELİK Serhat , GÜVEN Zeynep Tuğba , AŞIK Onur , KEKLİK Muzaffer , KAYNAR Leylagül , ESER Bülent , ÇETİN Mustafa , ÜNAL Ali 
Published: January 2023

Aim: Langerhans cell histiocytosis (LCH) is a proliferative disease caused by abnormal proliferation of histiocytes in the bone marrow dendritic cell structure. LCH is very rare in adults and its incidence is 1-2 cases per million. Therefore, there is still no clear management plan in adults. It was aimed to evaluate the very rare adult LCH patients.
Materials and Methods: Ten LCH patients who were followed up at Erciyes University Hematology Department between January 2010 and January 2020 were included.
Results: Eight (80%) of them were male and 2 (20%) were female. The median age of the patients was 34.5 ± 8.4 (23-52) years. Although the most common involvement at the time of diagnosis was bone in 7 patients (70%) and lung in 3 patients (30%); pituitary, tympanic membrane, liver and brain involvement were also observed. Three (30%) patients had single system involvement and 7 (70%) had multisystem. Four (40%) patients had relapsed and all had multisystemic involvement. The BRAF V600E mutation could be performed in 3 patients. It was negative in two patients and positive in 1 patient. All patients still have remission.
Conclusion: Unlike children, LCH has a better course in adults. The most important approach is to determine single or multisystem involvement. In our patients with single system involvement, we obtained response with corticosteroid and surgery alone. We have observed that vinblastin plus metilprednizolon treatment is a good option for multisystemic involvement. In relapsed patients, we obtained a significant response with clofarabine.
ANALISIS PENGARUH PENYERTAAN MODAL NEGARA, SOLVABILITAS, LIKUIDITAS DAN PERTUMBUHAN AKTIVA TERHADAP KINERJA KEUANGAN BUMN
Authors: Mada Andreas , Dati Titis Wahyu 
Published: January 2023

Financial performance was an indicator that showed the future prospects for the company's sustainability. By researching financial performance, it will likely be able to measure the effectiveness of providing state equity participation to Indonesia's State-Owned Enterprises (SOEs) because every year, the government always allocates a large budget. However, few SOEs were losing money, and the losses were increasing yearly. Furthermore, it aimed to analyze the effect of solvency, liquidity, and asset growth on the financial performance of Indonesian SOE recorded on the BUMN20 Index for the 2018– 2020 period. Data was collected by using purposive sampling. Twelve SOEs listed on the BUMN20 Index were used as research samples. The analysis technique was multiple linear regression. State equity participation was calculated by comparing equity with total assets. The solvency ratio used was the debt ratio and the liquidity ratio used was the current ratio. Asset growth was calculated by calculating the annual change in total assets, while ROE and ROA calculated financial performance. The study showed that state equity participation had no significant effect on financial performance, while solvency and asset growth significantly negatively affected financial performance. The liquidity had a significant negative effect on financial performance when measured by ROE, while if measured by ROA, the results were insignificant. Kinerja keuangan merupakan indikator yang menunjukkan prospek keberlangsungan perusahaan pada masa yang akan datang. Dengan melakukan penelitian pada kinerja keuang- an diharapkan mampu mengukur keefektifan pemberian PMN pada perusahaan BUMN karena setiap tahunnya pemerintah selalu mengalokasikan anggaran yang besar untuk Penyertaan Modal Negara pada BUMN. Namun, tidak sedikit BUMN yang justru merugi dan kerugiannya semakin besar setiap tahunnya. Selain itu, penelitian ini juga bertujuan menganalisis pengaruh solvabilitas, likuiditas dan pertumbuhan aktiva pada kinerja keuangan Badan Usaha Milik Negara yang tercatat pada Indeks BUMN20 periode 2018–2020. Teknik sampling yang dipakai pada penelitian ini adalah purposive sampling. Terdapat 12 (dua belas) BUMN yang tercatat pada Indeks BUMN20 yang dipakai sebagai sampel penelitian. Teknik analisis yang dipakai adalah regresi linear berganda. Hasil penelitian menyimpulkan bahwa penyertaan modal negara tidak berpengaruh secara signifikan pada kinerja keuangan, sedangkan solvabilitas dan pertumbuhan aktiva berpengaruh negatif signifikan pada kinerja keuangan. Adapun likuiditas berpengaruh negatif signifikan pada kinerja keuangan jika diukur dengan ROE, sedangkan jika diukur dengan ROA hasilnya adalah tidak signifikan.
Finding Peas in the Early Universe with JWST
Authors: Rhoads James E. , Wold Isak G. B. , Harish Santosh , Kim Keunho J. , Pharo John , Malhotra Sangeeta , Gabrielpillai Austen , Jiang Tianxing , Yang Huan 
Published: January 2023

Abstract
The Early Release Observations (EROs) of JWST beautifully demonstrate the promise of JWST in characterizing the universe at Cosmic Dawn. We analyze the Near Infrared Spectrograph ERO spectra of three z ∼ 8 galaxies to determine their metallicities, gas temperatures, and ionization. These galaxies offer the first opportunity to understand the physical properties of Epoch-of-Reionization galaxies through detailed rest-optical emission-line spectroscopy. We show that these objects have metal abundances

12
+
log
[
O

/

H
]

≈

6.9–8.3, based on both the T

e
method and on a recent calibration of the R
23 metallicity indicator. Since the spectra are some of the earliest science data from JWST, we compare several line ratios with values expected from robust physics, to validate our measurement procedures. We compare the abundances and emission-line ratios to a nearby sample of Green Pea galaxies—a population of nearby emission-line galaxies whose UV properties resemble Epoch-of-Reionization galaxies, and which often have large Lyman continuum escape fractions. The JWST data show striking further similarities between these high-redshift galaxies and nearby Green Peas. The z ∼ 8 galaxies span the metallicity range covered by Green Peas. They also show the compact morphology that is typical of emission-line-dominated galaxies at all redshifts. Based on these similarities with Green Peas, it is likely that these are the first rest-optical spectra of galaxies that are actively driving cosmological reionization.
Transition Into Practice: Outcomes of a Nurse Residency Program
Authors: Miller Cheryl M. , Meyer Kelsey , Riemann Laurie A. , Carter Benjamin T. , Brant Jeannine M. 
Published: January 2023

Background
Nurse residency programs (NRPs) have been proposed to meet the educational needs of new graduate nurses and facilitate the transition into practice. Although most studies indicate the benefits of NRPs to assist nurses during transition into practice, only one study compared an NRP with a control group. This study examined whether nurses in an NRP transitioned into practice more successfully than nurses in a traditional orientation program.

Method
This study enrolled 106 newly employed graduate nurses into study arms by unit: a nurse residency intervention group or a control group of standard nursing orientation. Casey-Fink Readiness for Practice, Nurse Retention, and Nurse Job Satisfaction surveys measured group outcomes.

Results
Readiness for practice improved significantly for nurse residents, as did nurse retention perceptions, indicating that nurse residents were more likely to be retained at the organization. The 1- and 2-year nurse retention rates during the 3 years of the study showed marked improvement.

Conclusion

The NRP resulted in improved readiness for practice, improved nurse retention, and higher job satisfaction compared with standard orientation.

[
J Contin Educ Nurs
. 2023;54(1):32–39.]
Do Jaw Deformities Adversely Affect Largemouth Bass?
Authors: Sylvia Andrea , Weber Michael J. , Froman Tyler 
Published: January 2023

Abstract
Largemouth Bass Micropterus nigricans anglers have mainly adopted catch-and-release practices with limited direct fishing mortality. However, catch-and-release angling could cause delayed mortality and nonlethal effects that could potentially affect population dynamics. For instance, hooking can result in jaw deformities, with unknown subsequent effects on vulnerability to angling, condition, growth, and mortality. Our objectives were to assess the prevalence of Largemouth Bass jaw deformities and test for differences in angling vulnerability, growth, condition, size structure, and mortality of fish with and without jaw deformities. Largemouth Bass were captured by electrofishing and by anglers at 41 tournaments at Brushy Creek Lake, Iowa, between April and August 2015. Jaw deformities were observed in 7.0% of fish caught at tournaments and 3.3% caught while electrofishing (5.8% overall). Angling recapture rates of tagged fish with (78.9%) and without (76.8%) jaw deformities were similar. Condition, growth, size structure, and mortality of fish with and without jaw deformities were also similar. Our results indicate jaw deformities have little effect on Largemouth Bass angling vulnerability, condition, growth, or survival; however, we still recommend careful handling of fish to minimize injuries that may occur during angling.
High Similarity in Winter Diet between Imperiled New England Cottontail and Invasive Eastern Cottontail
Authors: Carter Wales A. , McGreevy Thomas J. , Gerber Brian D. , Mayer Amy E. , Sullivan Mary E. , Tefft Brian C. , Husband Thomas P. 
Published: January 2023

Abstract
Ongoing declines in the imperiled New England cottontail Sylvilagus transitionalis have coincided with the introduction and expansion of the closely related eastern cottontail Sylvilagus floridanus. These paired population trends have led to the inference of competition between the two species. Competition between native and introduced species has often involved overlapping use of food resources, but limited effort has been spent to analyze the diets of New England cottontail and eastern cottontail and to evaluate the potential for resource competition. We used microhistologic analysis of fecal pellets to assess the winter diets of both species and we compared diet composition with available plant communities to evaluate their preferences for dietary items across southern New England and southeastern New York. We found no differences in diets between New England cottontail and eastern cottontail, although diets did differ between regions within the study area. Diet preferences also were consistent between the species and largely excluded nonnative plant genera. Our results demonstrate that these species are generalist herbivores and that there is high potential for competition for food resources in the winter between them, although the present lack of diet partitioning may indicate the presence of other factors limiting competition. This study highlights the need for careful evaluation of interactions between native and nonnative species, a prerequisite for developing conservation plans that appropriately account for interspecific competition.
Molecular bases for inherited human complement component C6 deficiency in two unrelated individuals.
Authors: Nishizaka H , Horiuchi T , Zhu Z B , Fukumori Y , Nagasawa K , Hayashi K , Krumdieck R , Cobbs C G , Higuchi M , Yasunaga S , Niho Y , Volanakis J E 
Published: January 2023

Abstract
Deficiency of the sixth component of complement (C6D) is frequently associated with recurrent neisserial infections, especially meningitis caused by Neisseria meningitidis. We here report the molecular bases of C6D in two unrelated subjects, one African American (case 1) and the other Japanese (case 2). Screening all 17 exons of the C6 gene and their boundaries by exon-specific PCR/single strand conformation polymorphism demonstrated aberrant single stranded DNA fragments in exon 12 of case 1 and exon 2 of case 2. Nucleotide sequencing of the amplified DNA fragments revealed a homozygous single-base deletion (G1936) in exon 12 case 1 and a heterozygous single base deletion (C291/C292/C293/C294) in exon 2 of case 2. Both mutations resulted in frame shifts and premature termination of the C6 polypeptide. Sequence-specific oligonucleotide probe hybridization and direct sequencing of exon 12 amplified from genomic DNA further supported the homozygosity of the mutation in case 1. Case 2 is apparently compound heterozygote, but the putative mutation in the other allele of the C6 gene remains unknown. Both case 1 and case 2 were homozygous for the C6A allotype. These data indicate that at least three distinct mutational events can cause C6D, single nucleotide deletions in exons 2 and 12, and a mutation yet unidentified. Thus, similar to other complement protein deficiencies, the pathogenesis of C6D appears to be heterogeneous.
Adenosine pathway is associated with the control of immune activation and inflammation in nonprogressive SIV infection (VIR1P.1009)
Authors: He Tianyu , Brocca Cofano Egidio , Gillespie Delbert , Xu Cui Ling , Kristoff Jan , Ross Samantha , Ma Dongzhu , Haret-Richter George Sebastian , Rinaldo Charles , Jackson Edwin , Macatangay Bernard , Apetrei Cristian , Pandrea Ivona 
Published: January 2023

Abstract
Adenosine (ADO) is associated with immunosuppression in multiple diseases, yet its role in modulating immune activation/inflammation (IA/INFL) in HIV-1/SIV infection is unclear. We compared changes in ADO pathway-associated markers between African green monkeys (AGMs) that control SIV-related IA/INFL and pigtailed macaques (PTMs) that exhibit IA/INFL associated with AIDS progression. CD39/CD73 and CD26 (which promote ADO production or breakdown to inosine) were assessed by flow cytometry on T cells from blood, lymph nodes (LNs) and intestine of AGMs and PTMs pre and post SIV infection. ADO was measured by mass spectrometry in frozen tissues. Baseline CD39/CD73 expression on Tregs from LNs and intestine were intrinsically high in AGMs and remained high throughout SIV infection. CD26 and inosine did not change in AGMs. In the gut, basal ADO was high in AGMs and further increased early after infection. Conversely, in PTMs, CD26 expression dramatically increased in the gut early in infection, a change associated with increased inosine. CD39/CD73 only increased during late infection in PTMs. Our results suggest a key role for ADO in the control of IA/INFL in nonprogressive SIV infections and that ADO production may be counteracted by the early increase of CD26 in pathogenic HIV/SIV. Furthermore, changes of ADO levels predominately occur in the gut rather than in blood or LNs, suggesting that future studies of the ADO pathway should focus on mucosal sites of viral replication.
Targeted IL-10 locally suppresses inflammation in atherosclerotic sites
Authors: Volpatti Lisa R , Hubbell Jeffrey A 
Published: January 2023

Abstract
Atherosclerosis is a main contributor to cardiovascular disease, the leading cause of death in the U.S. Preventative measures include statins or dietary changes to reduce “bad cholesterol” or low-density lipoprotein (LDL) that accumulates on arterial walls to form plaques. However, these treatment options often lead to surgical interventions associated with high cost and morbidity. Although atherosclerosis is now recognized as a chronic inflammatory disease, no therapies targeting the underlying immunology are currently approved.
The objective of this project is to locally suppress inflammation at atherosclerotic sites. IL-10 has been shown to suppress vascular inflammation, but its poor pharmacokinetic profile and possible side effects limit its therapeutic potential. To overcome these challenges, we engineered fusion proteins in which one side is IL-10 and the other side is an antibody fragment (Fab) that binds to protein epitopes of LDL. Thus, we specifically target IL-10 to atherosclerotic plaques.
We validated the fusion proteins in vitro, confirming Fab binding affinity with surface plasmon resonance and IL-10 bioactivity in a macrophage-like cell line. We subsequently evaluated their immunosuppressive effect in the apolipoprotein E−/− mouse model of atherosclerosis. LDL-binding Fab-IL-10 constructs significantly reduced the total number of leukocytes, macrophages, T cells, and B cells in the aorta to levels similar to wild type mice. Conversely, neither IL-10 fused to a Fab of irrelevant specificity nor native IL-10 showed any differences to untreated mice. Therefore, plaque-targeted Fab-IL-10 constructs effectively suppress local inflammation and show promise as novel atherosclerosis therapies.
Supported by NIH NHLBI T32, Chicago Immunoengineering Innovation Center
Pandemic-induced pan-academic educational response in a minority university.
Authors: Fazal Nadeem , Faridi Hafeez 
Published: January 2023

Abstract
Education system is extremely vulnerable to the consequences caused by COVID-19, especially the need to strengthen pharmacy education. We utilized this opportunity to rebuild education post-pandemic at Chicago State University College of Pharmacy. Of many avenues opened to development, teachers obligated to update their digital competencies. The pandemic had widened achievement gaps and exposed weaknesses in education systems we had an opportunity now to reimagine a more equitable and resilient education system that delivered a better education to all minority students. Current educational set up was built when our understanding of human learning and learners, knowledge, and skills, as well as teaching pedagogy and teachers’ expertise was quite different from present. Pandemic gave us one-time life window of opportunity to pause and update our educational needs. The purpose of this project was to support such a process of exchange of knowledge. The panic button was sounding and both educators and students were baffled by how to proceed in the wake of pandemic. We encouraged to implementing technology into science education in a way allowing both teachers and students to develop collaborative skill sets and advance adaptability. We recognized the need to support not only students but also students’ families, especially in vulnerable minority communities. We found a “spring effect” and found that pandemic-induced suppression of education bounced back and even rise above the level of past normal. Since it has involved the whole world (pandemic) the educational response should be (pan-academic) and hopefully it will serve as a solution to global problem (panacea) like (vaccine) for all.