bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of stress factors in the formation of gastroesophageal reflux disease in children: characteristics of anxiety-phobic and depressive disorders
Authors: Shubina M. V. , Tereshchenko S. Yu. , Gorbacheva N. N. 
Published: July 2023

Introduction. There is enough evidence of the influence of the psycho-emotional state of children on the development of gas-troesophageal reflux disease, numerous studies reveal anxiety and depressive disorders in them. However, there is no common understanding of the specific causal relationships underlying the pathogenesis of this disease.Aim. To identify the features and possible causes of anxiety and depressive disorders in children with gastroesophageal reflux disease and analyze their role using Yu.I. Burlan's system-vector psychology.Materials and methods. 677 adolescents aged 11-17 years were examined on the basis of the pediatric department in the Clinic of the Research Institute of Medical Problems of the North (Krasnoyarsk). The gastroesophageal reflux diseasewas diagnosed by testing according to the Russian version of the Gastroesophageal Reflux Disease Questionnaire. Computerized testing “The Development and Well-Being Assessment” was used to identify mental disorders.Results. In children with gastroesophageal reflux disease, all kinds of fears were significantly more common: fear of separation - 50.0 (25.1-74.9)%; darkness, thunderstorms, thunder, heights - 66.7 (38.6-86.1)%; blood injections, wounds - 58.3 (31.6-80.8)%; loud noise - 33.3 (13.9-61.4)%; to be far from home - 41.7 (19.2-68.4)%. 41.7 (19.2-68.4)% of children had manifestations of depression, which is 2 times more often than in the control group, and every fourth had self-harm. Separation from friends, panic attacks, fear of death, melancholy, resentment, learning problems, appearance were indicated as the causes of depression.Conclusions. The causal relationships disclosed by the system-vector psychology, according to which certain stress factors play an important role in the development of gastroesophageal reflux disease. These factors depend on the type of character: for emotional children, these are all kinds of fears, phobias, breaking emotional ties, problems in relationships with others, and for obedient and calm children - resentment, learning problems and any factor of novelty (change of the usual environment, living conditions, team).
Tourism in a Unique Destination
Authors: Moloni Pelagia 
Published: July 2023

Tourism in Antarctica has been dynamically developed in recent decades, although it is located in a small geographical part of continent. The main reason that visitors plan a trip to the destination, when the opportunity is given, is the natural landscape and wildlife. In addition, overheating of the planet that causes ice to melt has enhanced the feeling of fear as there is severe environmental concern for the coming years. Space and seasonal exclusions make it even more special and the tourist product which is offered by this continent is expensive and requires a lot of preparation. Tourism activity in such a fragile environment has sparked several reactions in the past, mainly from the scientific community, as it is the main recipient of the negative effects of tourism. Furthermore, organized efforts have been made so that the offered product will promote more environmentally friendly trips that will affect the ecosystem as little as possible.
The main objective of this research is to analyze this kind of tourism because of the need for new forms. The positive and negative impacts that tourism can have on the environment and the statistics on arrivals and countries of origin of tourists in recent years are analyzed. Moreover, the tourist packages that seem to be in the greatest demand of visitors are presented. The main research question of this paper is whether this destination can host intense tourism activity. Following an extensive bibliographic review, the research makes it clear that the study area cannot support strong tourism activity even though future tourism forecasts report an additional increase in arrivals.
Abating eutrophication on urban lakes: a case study of Kabaka's Lake, Uganda
Authors: Nakagiri Anne , Mutyaba Abel , Onyutha Charles , Okurut Kenan 
Published: July 2023

AbstractEutrophication of water bodies is a challenge in many urban areas. This study measured and modelled quantitatively the pollutant nutrient load of an urban lake (80,596 m2), and assessed both external (constructed wetland) and internal (dredging) eutrophication extenuation measures. For the past 25 years, there has been redistribution (p &lt; 0.005) of the lake's catchment land use, with built-up area increasing by 78.5%, and a reduction in vegetated (37.2%) and water surface (1.8%) areas. A 92.2% reduction in the lakes receiving wetland footprint (p = 0.000003) was noted, with increased nutrient load. The lake's light attenuation was found to be dominated by algae, limited by nitrogen and classified under the oligotrophic class (Trophic State Index &lt; 40), with a threat of eutrophication in an estimated 25 years. Scenario analyses show that the construction of a wetland in the remaining 0.54 hectares of natural wetland will reduce total phosphorus by 35% and total nitrate by 45% (p = 0.05), whereas dredging the lake could reduce them by 80% each (p = 0.0005). Watershed management is the only sustainable solution to control nutrient flow into the lake and enable self-cleansing, factoring in the design of the receiving wetland and groundwater sources.
Struvite separation from wastewater and its use with sulfur-oxidizing bacteria improves phosphorus utilization in alkaline soil
Authors: Rehman Sana ur , Ijaz Shahzada Sohail , Raza Muhammad Ali , Fatima Shroz , Javed Nabeeha , Irfan Muhammad , Hussain Sajad , Siddiqa Ayesha , Lateef Muhammad , Khan Atta ur Rehman , Khan Rameez Akram , Ahmad Touqeer 
Published: July 2023

AbstractA major portion of phosphatic fertilizer comes from the limiting natural resource, rock phosphate, which demands a timely alternative. Struvite, a crystalline mineral of low solubility, is a worthwhile alternative. Evaluation of the local wastewater streams for their ability to precipitate struvite and its capability as phosphatic fertilizer under an alkaline soil environment was studied. Two stirring speeds, a pH range of 8.0–11.0, and a constant molar ratio were used to optimize local wastewater streams for struvite precipitation. Struvite was used in five different combinations to assess the release of phosphorus (P), including control (no P source), single superphosphate, struvite, struvite + sulfur, and rock phosphate with or without inoculation of sulfur-oxidizing bacteria (SOB). For struvite precipitation, low stirring speeds are ideal because the precipitates readily sink to the bottom once they form. Furthermore, the amalgamation of SOB with sulfur significantly improved P use efficiency under alkaline soils through increased phosphorus sources solubility and enabled optimum wheat production due to its low solubility in an alkaline soil condition. Due to its capacity to recycle phosphorus from wastewater, struvite is poised to emerge as a sustainable fertilizer and had an opportunity to capture a share of this expanding market.
Специфика исполнительных когнитивных функций у людей с разным опытом употребления алкоголя
Authors: Пешковская Анастасия Г. 
Published: July 2023

Introduction. Executive functions are multidimensional cognitive processes that provide organization and regulation of behavior. Impairments in executive functions are considered to be a risk factor for addiction, including alcohol dependence. However, it is not clear which domains of executive functions are the most vulnerable and how their changes relate to progression to addiction.
Methods. A total of 244 individuals with different alcohol consumption experiences (78 with safe alcohol consumption and 166 with diagnosed alcohol dependence) participated in this study. Executive functions were investigated with the Go/No-Go task, the Simon Test, the Wisconsin Card Sorting Test, and the Corsi Block-Tapping Test, implemented in a computerized version on the Cognitive Symphony platform (Russia). In participants with alcohol dependence, data on dependence duration, remission duration, and treatment courses were also considered.
Results of the study showed that participants with alcohol dependence had significantly lower outcomes of executive cognition performance than those who practiced safe alcohol consumption. In particular, alcohol-dependent participants performed worse in cognitive control task (p = 0.0001), attention task (p = 0.026), and cognitive flexibility task (p = 0.006 and p = 0.040). Working memory was also found to be vulnerable, with all alcohol-dependents who performed with lower working memory span compared to participants with safe alcohol consumption (p = 0.044). Subsequent regression analysis showed that cognitive control errors and cognitive flexibility errors in individuals with alcohol dependence were associated with years of alcohol abuse (p < 0.01). In addition, the higher rate of progression to alcohol dependence, the more vulnerable was working memory (p = 0.002559).
Discussion. The study showed that executive cognition vulnerability in people with alcohol dependence was associated with alcohol abuse duration and dependence progression rate. The study results may contribute to intervention programs that target executive cognitive functions in alcohol addicts and those at high risk for alcohol dependence.
Happiness in the Workplace of Women Lecturers Based on Work-Family Balance and Work Engagement
Authors: Handayani Nita Sri , Ancok Djamaludin , Putri Dian Kemala 
Published: July 2023

Introduction. Happiness at work is one of the components that can determine the achievement of one's success at work. Lecturers are teaching staff at the tertiary level who are an important component of the education system. Lecturers who have happiness at work will have a higher work engagement with their work, have a high concentration in doing their work, are always enthusiastic in doing all their work, and are always enthusiastic in completing all their work. The purpose of this study was to theoretically test the variables of work-family balance and work engagement on the happiness of female lecturers.
Methods. This research is quantitative research with non-experimental methods. Respondents in this study consisted of 200 female lecturer respondents, who had worked for at least 1 year, had been married for at least 1 year, and had a Masters's degree. The sampling technique in this study was purposive sampling. There are three measurement tools used in this study, namely happiness at work, work-family balance, and work engagement.
Results and Discussion. Retrieval of data in this study using a questionnaire in the form of google form. Testing the validity of this study using the Content Validity Ratio (CVR) which involves an expert in psychology. Data analysis in this study used multiple linear regression analysis techniques with the help of the SPSS.26 for windows program. The research results show that the hypothesis in this study is accepted. This means that the work-family balance and work engagement variables have a very significant effect on the happiness of female lecturers by 67.8%.
Cytotoxic and DNA-binding Capacity of Titanocene Functionalized
Mesoporous Nanoparticles in Breast Cancer Cell Lines MCF-7 and
MDA-MB-231
Authors: Serrano-Pindado Álvar , Iorhemba Michael Aondona , Díaz-García Diana , Díaz-Sánchez Miguel , Mena-Palomo Irene , Gómez-Ruiz Santiago , Prashar Sanjiv 
Published: July 2023

Aims:
The fight against cancer is an active research topic that combines several disciplines to find
suitable agents to treat various tumours.

Background:
Following cisplatin, organometallic compounds, including titanocene derivatives, have been tested
as antitumoral agents. However, key issues still need to be addressed in metallodrug chemotherapy relating
to solubility, stability, and dosage. Mesoporous silica nanoparticles, being low toxic biocompatible materials
with high loading capacity, are ideal candidates to overcome these problems.

Objective:
This study aimed to prepare and structurally characterize titanocene functionalized mesoporous silica
nanoparticles and evaluate their cytotoxic activity against cancer cells.

Methods:
The preparation of titanocene functionalized mesoporous silica nanoparticles was achieved by synthetic
protocols, involving either grafting or tethering. Characterization was carried out using standard techniques,
FT-IR, XRD, XRF, TEM, and BET. The titanocene functionalized materials were studied as antitumoral
agents in the breast cancer lines MCF-7 and MDA-MB-231.

Results:
The functionalized MSN showed promising antitumoral activity against cells lines MCF-7 and MDAMB-
231 up to 9 times more than titanocene alone.

Conclusion:
This study reported the potential of titanocene-functionalized mesoporous silica nanoparticles in
future chemotherapeutic actions.
Flavonoid and Chalcone Scaffolds as Inhibitors of BACE1: Recent
Updates
Authors: Narayanan Anishma Payyappilliparambil , Jayan Jayalakshmi , Sudevan Sachithra Thazhathuveedu , Dhyani Archana , Zachariah Subin Mary , Mathew Bijo 
Published: July 2023

Abstract:
Flavonoids and chalcones are two major classes of chemical moieties that have a vast
background of pharmacological activities. Chalcone is a subclass of flavonoids whose therapeutic
potential has been implicated due to an array of bioactivities. A lot of research works have shown
interest in investigating the neuroprotective effect of these molecules, and have revealed them to be
much more potent molecules that can be used to treat neurodegenerative disorders. Beta-site APP
cleaving enzyme (BACE1), which is majorly found in the brain, is one of the reasons behind the
development of Alzheimer’s disease (AD). Flavonoids and chalcones have proven clinical data that
they inhibit the production of Aβ plaques that are involved in the progression of AD. In this article,
we have provided a detailed chronological review of the research work on the BACE1 inhibiting
potency of both flavonoids and chalcones. Almost all the flavonoids and chalcones mentioned in
this article have shown very good in vitro and in vivo BACE1 inhibiting activity. The docking
studies and the structural importance of some BACE1-inhibiting flavonoids, as well as chalcones,
are also mentioned here.
A Mini-review on Recent Strategies and Applications of Nanomedicines to Combat
Antimicrobial Resistance
Authors: Chahar Kanak , Sharma Yash , Patel Preeti , Asati Vivek , Das Kurmi Balak 
Published: July 2023

Abstract:
One of the key factors contributing to mortality and morbidity globally is infectious ailments. According
to recent statistics from WHO, amplified antimicrobial resistance occurrence among bacteria signifies the utmost
threat to global public health. Bacteria have developed various strategies to resist antimicrobials, including enzymatic
inactivation of antibiotics, drug efflux, modifications of the antibiotic molecule or chemical alteration of the antibiotic,
limited drug uptake, etc. Furthermore, the inefficiency of antimicrobial drugs against resistant bacteria due to
low solubility, instability, and associated side effects augments challenges to combat these resistant pathogens. This
has attracted the attention of researchers to create nano-delivery and targeting techniques. This review presents an
overview of antimicrobial resistance (AMR), its various subtypes, as well as mechanisms involved in AMR. This
review also describes current strategies and applications of various nanocarriers, including nanoparticles, liposomes,
lipid-based nanoparticles, micelles, and polymeric nanoparticles.
The Role of Histone Deacetylases in NLRP3 Inflammasomesmediated Epilepsy
Authors: Kuang Xi , Chen Shuang , Ye Qingmei 
Published: July 2023

Abstract:Epilepsy is one of the most common brain disorders that not only causes death worldwide, but also affects the daily lives of patients. Previous studies have revealed that inflammation plays an important role in the pathophysiology of epilepsy. Activation of inflammasomes can promote neuroinflammation by boosting the maturation of caspase-1 and the secretion of various inflammatory effectors, including chemokines, interleukins, and tumor necrosis factors. With the in-depth research on the mechanism of inflammasomes in the development of epilepsy, it has been discovered that NLRP3 inflammasomes may induce epilepsy by mediating neuronal inflammatory injury, neuronal loss and blood-brain barrier dysfunction. Therefore, blocking the activation of the NLRP3 inflammasomes may be a new epilepsy treatment strategy. However, the drugs that specifically block NLRP3 inflammasomes assembly has not been approved for clinical use. In this review, the mechanism of how HDACs, an inflammatory regulator, regulates the activation of NLRP3 inflammasome is summarized. It helps to explore the mechanism of the HDAC inhibitors inhibiting brain inflammatory damage so as to provide a potential therapeutic strategy for controlling the development of epilepsy.
Nabiximols is Efficient as Add-On Treatment for Patients with Multiple
Sclerosis Spasticity Refractory to Standard Treatment: A Systematic
Review and Meta-Analysis of Randomised Clinical Trials
Authors: Kleiner Dénes , Horváth István László , Bunduc Stefania , Gergő Dorottya , Lugosi Katalin , Fehérvári Péter , Hegyi Péter , Csupor Dezső 
Published: July 2023

Background:
Spasticity affects 54% of multiple sclerosis (MS) patients at disease onset, but
this rate gradually increases with disease progression. Spasticity does not fully respond to standard
treatment in one-third of the patients.

Objective:
Our systematic review and meta-analysis assessed whether add-on nabiximols, can improve
MS-associated refractory spasticity.

Methods:
The systematic literature search was performed in Web of Science, MEDLINE, Scopus, CENTRAL,
and Embase, on 15/10/2021, without restrictions. We included in the review blinded, randomized,
placebo-controlled trials evaluating the efficacy of nabiximols in adult MS patients with refractory spasticity,
by comparison with placebo. The primary outcome was responder rate by spasticity numerical rating
scale (NRS). Secondary outcomes were spasticity-related parameters. We used random effect models
to calculate odds ratios (OR) or mean differences and the corresponding 95% CI. Bias-factors were assessed
with Cochrane risk of bias tool (RoB2). (PROSPERO ID: CRD42021282177).

Results:
We identified 9 eligible articles, of which 7 (1128 patients) were included in the meta-analysis.
The spasticity numerical rating scale (NRS) was significantly higher in the nabiximols group than in the
placebo group (OR 2.41 (95% CI 1.39; 4.18)). Secondary outcomes were in accordance with our primary
results. At least some concerns were detected in the risk of bias analysis.

Conclusion:
Our results indicate that nabiximols is efficient in MS associated spasticity, refractory to
standard treatment and it may be considered as add-on symptomatic therapy. Nevertheless, further studies
are needed to establish the optimal treatment protocol – dose, duration, moment of initiation, disease type.
Cognitive Effects of Lurasidone and Cariprazine: A Mini Systematic
Review
Authors: Olivola Miriam , Bassetti Nicola , Parente Serena , Arienti Vincenzo , Civardi Serena Chiara , Topa Pietro Alessandro , Brondino Natascia 
Published: July 2023

Abstract:
Cognitive deficits are associated with schizophrenia and show a progressive worsening, often
being unresponsive to treatment. New antipsychotic molecules acting as antagonist at the serotoninergic
5-hydroxytryptamine receptor 7 (e.g. lurasidone) or partial agonists at dopamine D3 receptor
(e.g. cariprazine) could have an impact on cognition in this patient group. The aim of the systematic
review is to explore the efficacy of lurasidone and cariprazine in improving cognition in both animal
models and human studies. The following terms: (lurasidone AND cognit*) OR (cariprazine AND
cognit*) were searched in Web of Science from inception to December 2021. We included all studies
that assessed changes in cognitive function after treatment with cariprazine or lurasidone. Of 201 selected
articles, 36 were included. Twenty-four articles used animal models (rats, mice and marmosets),
five evaluating the effects of cariprazine and 19 the effects of lurasidone. Twelve articles were clinical
studies (cariprazine n = 2; lurasidone n = 10). In both animal and human studies lurasidone showed a
greater efficacy on cognitive performance compared to placebo, quetiapine, ziprasidone or treatmentas-
usual. Cariprazine was superior to other antipsychotics in improving cognitive functions in both animal
and human studies. The cognitive effect of lurasidone could be explained by its potent antagonism
at the 5-HT7 receptors combined with partial agonism at 5-HT1A receptors. The pro-cognitive effect
of cariprazine is probably explained by its very high affinity for D3 receptors. Head-to-head studies
comparing lurasidone and cariprazine are needed to establish the “first-choice” treatment for cognitive
dysfunction associated with schizophrenia.
The Use of Enzyme Inhibitors in Drug Discovery: Current Strategies and
Future Prospects
Authors: Singh Kuldeep , Gupta Jeetendra Kumar , Pathak Devendra , Kumar Shivendra 
Published: July 2023

Abstract:
Enzyme inhibitors are an important therapeutic agent in drug discovery, as they can be used
to manipulate biochemical pathways to treat a wide range of diseases. Current strategies for enzyme inhibition
involve the use of small molecule inhibitors, natural products, or peptide-based inhibitors. These
inhibitors can be used to target and modulate the activity of enzymes, which in turn can affect the
progression of a particular disease. The future of enzyme inhibitor-based drug discovery lies in the development
of more selective and potent inhibitors, as well as the ability to target enzymes that are involved
in multiple pathways. Additionally, there is significant potential for the use of enzyme inhibitors
in combination with other therapeutic strategies, such as gene therapy. Finally, the development of novel
computational strategies for the design and optimization of enzyme inhibitor-based drugs is an exciting
area of research. Such strategies could lead to the discovery of new and more effective inhibitors,
which would facilitate the development of improved treatments for a variety of diseases. Hence, this review
focuses on some techniques for the discovery of enzyme inhibitors and their applications as various
therapeutic agents.
A Brief Insight into Nanotherapeutic Approaches in the Management of
Analgesia
Authors: Garg Kritika , Kumar G. Santhana , Soni Arun , Pawar Saurav 
Published: July 2023

Background:
Growing public awareness of chronic pain resulting from illness and injury
has prompted pharmaceutical researchers and drug corporations to create better, more targeted painkillers.
For effective pain management, prolonged analgesic medication delivery at the intended areas
continues to be a major problem such as addiction, tolerance and other serious side effects, which can
prolong suffering and decrease painkiller effectiveness.

Objective:
The present paper focuses on review of current advances in the field of pain treatment by
different nanoparticles formulations of various drugs, by enhancing their pharmacokinetic factors and
diminishing associated adverse effects.

Results:
According to literature survey, usage of nano-carriers enables the delivery of these drugs to
target locations with less systemic toxicity. Nanotechnology for varied therapeutic purposes, different
analgesics have been loaded onto different nano carriers, including those that are natural, synthetic,
and polymeric and proven to be beneficial in pain management.

Conclusion:
Overall, new nano based preparations and new ways to utilize existing medications in a
variety of circumstances is a multimodal approach to pain relief, have resulted in recent advancements
in the pharmacological management of pain.