bluuebunny/crossref_metadata_2025_split huggingface dataset:
Red cell distribution width and neutrophil-lymphocyte ratio as inflammatory markers in patients with rheumatoid arthritis
Authors: Kushwaha Shekhar , Kaushik Reshma , Kakkar Rajesh , Kaushik Rajeev 
Published: March 2023

ObjectivesThe aim was to study the red cell distribution width (RDW) and neutrophil-lymphocyte ratio (NLR) as inflammatory markers and their correlation with clinical disease activity parameters in patients with rheumatoid arthritis (RA).Material and methodsThis observational cross-sectional study included 100 randomly selected patients with RA. Disease Activity Score with 28-joint counts and erythrocyte sedimentation rate (DAS28–ESR) was taken as a marker of disease activity. The diagnostic value of NLR and RDW in RA was assessed.ResultsThe majority (51%) of cases showed mild disease activity. The mean NLR in cases was 3.88 ±2.59. Mean RDW was 16.25 ±2.49%. Neutrophil-lymphocyte ratio significantly correlated with ESR (p = 0.026), severity of pain (p = 0.013), osteoporosis (p = 0.014) and radiographic joint erosions (p = 0.048), but not with DAS28–ESR (p > 0.05) and C-reactive protein (CRP) (p > 0.05). Red cell distri-bution width showed a significant correlation only with NLR (p = 0.009). The positive predictive values of NLR and RDW for disease activity were 93.3% and 90% and the negative predictive values were 20% and 16.7% respectively. For NLR, the area under the curve (AUC) was 0.78 (p = 0.001) and at a cut-off value of 1.63, the diagnostic sensitivity was 97.7% and specificity 50%. For RDW, the AUC was 0.43 (p = 0.40) and at a cut-off value of 14.52, the diagnostic sensitivity was 70.5% and specificity 41.7%. The sensitivity and specificity of NLR were higher than those of RDW. A significant difference was seen between the AUC of NLR and RDW (p = 0.02).ConclusionsNeutrophil-lymphocyte ratio is a valuable inflammatory marker in patients with RA, but RDW is not useful in this regard.
Systemic sclerosis and rheumatoid arthritis overlap syndrome – management of severe cardiac, pulmonary and articular involvement
Authors: Pinto Ana Sofia , Santos Filipe , Paiva Dinis Sara , Madeira Nathalie , Fonseca Ferreira Joana , Vaz Claúdia 
Published: March 2023

IntroductionThe presence of another rheumatological condition in patients with systemic sclerosis (SSc) is not uncommon. To report a case of a patient with SSc-RA overlap and perform a review of the cases re-ported in the literature.Material and MethodsA chart review of the present case report was performed. After, we performed a literature search in MEDLINE, EMBASE and Cochrane databases.ResultsWe included 26 articles. Sixty-three patients were reviewed, 51 were female with a mean age of 45.03 years at the time of the first diagnosis. Sixty-three patients were diagnosed with limited cu-taneous SSc. Regarding organ involvement, the most frequently reported were cutaneous, vascular, pulmonary and gastrointestinal involvement. Erosions were presenting 65.08% of patients. A panoply of treatments was used.ConclusionsThe authors concluded that screening for an associated disease should be encouraged since the overlap with SSc may affect prognosis and treatment.
Rain process models and convergence to point processes
Authors: Hottovy Scott , Stechmann Samuel N. 
Published: March 2023

Abstract. A variety of stochastic models have been used to describe time series of precipitation or rainfall.
Since many of these stochastic models are simplistic,
it is desirable to develop connections between the stochastic models
and the underlying physics of rain.
Here, convergence results are presented for such a connection
between two stochastic models:
(i) a stochastic moisture process as a physics-based
description of atmospheric moisture evolution and (ii) a point process for rainfall time series
as spike trains.
The moisture process has dynamics that switch after the moisture hits a threshold, which represents the onset of rainfall and thereby
gives rise to an associated rainfall process.
This rainfall process is characterized by its
random holding times for dry and wet periods. On average, the holding times for the wet periods are much shorter than the dry ones, and, in the limit of short wet periods, the rainfall process converges to a point process that is a spike train.
Also, in the limit, the underlying moisture process becomes a
threshold model with a teleporting boundary condition.
To establish these limits and connections,
formal asymptotic convergence is shown using the Fokker–Planck equation, which provides some intuitive understanding. Also, rigorous convergence is proved in mean square with respect to continuous functions of the moisture process and convergence in mean square with respect to generalized functions of the rain process.
Primal Familiarity
Authors: Polster Erving 
Published: March 2023

ABSTRACT
This article proposes a concept of primal familiarity, which gives increased importance to a fusion of basic life energy and the everyday happenings in our lives. It expands attention to the vital role that this accentuation of familiarity plays not only in our everyday lives but also in the psychotherapy process and its communal possibilities. It also highlights the concept of ordinary familiarity as a guiding force that illuminates the geography of a lifetime. It expands these principles to create a communal relevance in the form of Life Focus Groups. These groups represent the expansion of ordinary therapeutic practice into the development of lifelong congregations, bringing attention to the nature of living in community, as contrasted with the more personal individual benefits of ordinary psychotherapy. It represents psychotherapy as an heir to religion, and as a force in the communal exploration of the lives people live.
Enhancing Dialogue about Cultural Difference through Gestalt Group Work Theory and Practice
Authors: Tucker Patricia 
Published: March 2023

ABSTRACTGestalt therapy groups hold a unique potential to enhance our cultural understanding of one another through the use of communication structures that create and maintain the conditions for authentic dialogue and provide a safe container for group participants. This article details aspects of Gestalt theory that support the development of a broader sociocultural lens through modeling and teaching communication guidelines that help to facilitate groups. Group members are supported in reaching toward dialogue as they strive to gain a deeper meeting with the cultural other.
Recent changes in cross-regional convergence patterns
Authors: Auciello Iván , Puente Sergio 
Published: March 2023

RationaleEconomic convergence measured by income per capita refers to the process whereby lower income regions post higher growth, so that over time cross-regional differences diminish. This process was quite intense in Spain from 1980 to 2008 when, coinciding with the onset of the financial crisis, it came to a halt. Accordingly, it is of interest to document this phenomenon and investigate its possible causes.Takeaways•Economic convergence between the Spanish regions was intense from 1980 to 2008, when it came to a halt following the outbreak of the financial crisis.•Labour productivity, largely driven by capital accumulation, was the main determinant of the convergence process between 1980 and 2008. It is also the main contributor to its subsequent stagnation.•However, in the most recent period, population ageing, which is especially pronounced in regions with higher income per capita, has helped to narrow the differences, albeit not sufficiently to offset the impact of the other factors.
Estudio exploratorio para la validación de la Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) en la población con Esclerosis Múltiple Remitente Recurrente del Hospital San Juan de Dios en Santiago de Chile
Authors: Matus Paulina , Carrasco Tamara , Guajardo Grisell , López Valeria , Rivera Javiera , Toledo Lilian , Quezada Camilo 
Published: March 2023

La evaluación cognitiva en personas con esclerosis múltiple (EM), es un área fundamental a tener en cuenta en el proceso de intervención, debido a la alta prevalencia de deterioro cognitivo el cual es considerado como discapacitante y que repercute en la calidad de vida de la persona que lo padece y en su red más próxima.
En la actualidad se ha recomendado la evaluación cognitiva por medio de la BICAMS (del inglés Brief International Cognitive Assessment for MS), que es una batería específica para evaluar a personas con EM, pero que no cuenta con su validación en nuestro país. Es por esto que el presente estudio busca determinar los factores que se deben considerar para su futura validación. La muestra estuvo compuesta por 38 personas con EMRR y como resultado se obtuvo que sí influyen en el rendimiento cognitivo los factores de edad y género, no así escolaridad, meses de evolución de la enfermedad y nivel de discapacidad. Dentro de las pruebas cognitivas el BVMT-R es el que más demostró, y de forma significativa, relación con las variables de edad y género. Se recomienda aumentar el tamaño muestral y aplicarlo en otras regiones del país para contar con una muestra representativa de la población chilena.
THE EFFORTS OF THE PROSPERITY IN ERADICING THE CRIME OF MONEY LAUNDERING (A Research in the Legal Area of the Medan District Attorney)
Authors: Akmal Samosir  
Published: March 2023

As for who became objective from study ie For know the role of the prosecutor's office in eradicating money laundering crimes, knowing the obstacles faced by prosecutors in eradicating money laundering crimes and knowing the efforts made by prosecutors in tackling money laundering crimes . Results study This show Role attorney in eradication follow criminal washing Money started from stage tracking , blocking , confiscation , confiscation And stage return . Obstacles encountered attorney in eradication follow criminal washing Money covers constraint juridical like overlap overlapping authority investigation And transaction finances done in a manner cash. Then constraint technical covering lack of understanding follow Criminal Washing Money By Regulated Society In Law No. 8 of 2010., Lack Courage investigator In Carry out the Investigation Process follow Criminal Washing Money , Lack Amount Owning Investigator Honesty High, Lack Quality / ability understanding investigator To follow Criminal Washing Money . Attempts made attorney in cope follow criminal washing Money through effort juridical And effort technical . Effort juridical like do coordination with operational Police And coordination With Affiliated institutions in the Criminal Justice System (CJS). This is Law enforcement officials should coordinate and cooperate well with all relevant agencies in implementing law enforcement against perpetrators of money laundering so that law enforcement efforts can run well and optimally. Coordination between law enforcement agencies needs to be improved so that there are no overlapping investigations nor money laundering investigation for the predicate crime, so that efforts to eradicate money laundering crimes can proceed quickly and in accordance with what is aspired to. It is advisable for law enforcement officers to carry out good socialization to all relevant agencies and the public in the implementation of law enforcement against perpetrators of money laundering crimes so that law enforcement efforts can run well and optimally.
Effect on Video Conference’s Education in Mandangin’s Community Health Center’s Healthcare Knowledge about Acute Diarrhea in Children
Authors: Alpha Fardah Athiyyah  , Andy Darma  , Dwiyanti Puspitasari  , Khadijah Rizky Sumitro  , Ni Nyoman Metriani Nesa  , Steven Christian Susianto  , Muhammad Faizi  , Reza Gunadi Ranuh  , Subijanto Marto Sudarmo  
Published: March 2023

Introduction: The involvement and ability of health workers in Mandangin Island in early managing acute diarrhea in children to reduce infant mortality due to diarrhea are very important. This study aimed to determine the effect of community development Faculty of Medicine Universitas Airlangga - Dr. Soetomo General Academic Hospital Surabaya in a seminar on Early Management of Acute Diarrhea in Children using video conference to educate health care workers (HCWs) at the Mandangin Community Health Center.
Material and Methods: This cross-sectional study was designed on 20 HCWs at the Mandangin community health center. Subjects were evaluated for demographic data (gender, age, occupation, last education), and the knowledge was assessed using a pre-test before the seminar was given. We used questionnaire about acute diarrhea containing 10 questions with maximum score 100. The seminar was given through video conferences with form classical lecturer and a case study on acute diarrhea, and subjects attended the seminar in Community Health Center’s Hall. We assessed knowledge after the seminar using the same questionnaire with randomization in question and answer and compared the pre-and post-test using the Wilcoxon Rank sum test.
Results: Most of the subjects were midwifery, with a mean age of 32.4 ± 5.75 years old, 45% with D-3 last education and 80% were female. There was a significant difference between pre-and post-test in acute diarrhea in children (47.89±20.7 vs 64.74±22.94) (p=0.008).
Conclusion: Video conference education effectively increased health care workers' knowledge about acute diarrhea in children
Normative Data of Fugl Meyer Assessment on Upper Extremity in Post Stroke Population
Authors: Yasmin Naila , Tahir Iqra , Jabeen Hira , Yousaf Qandeel , Batool Umber 
Published: March 2023

Background: Stroke is clinically diagnosed as an acute, localized neurological impairment that is caused by vascular damage (infarction, hemorrhage) to the central nervous system. This main leading cause of demise and dysfunction worldwide resulting in frequent deficit, hemiplegia, which briefly affects upper limb. This multicentered study is the first to provide updated normative reference values for FMA-UE in post stroke adults in wide range of age in Pakistan’s population.
Objective: To determine Pakistani normative values of Fugl-Meyer Assessment on upper extremity in post Stroke Population.
Methods: Descriptive cross-sectional study on 1260 post-stroke patients was conducted in various public and private physiotherapy centers of country using Fugl-Meyer Assessment (Upper-Extremity) FMA-UE scale after ethical approval. Hemiplegic survivors of both genders aged 45-75 years were taken using convenience sampling technique, informed consent was taken. Statistics was done using SPSS version25.
Results: Patients included were 88.3% ischemic and 11.7% hemorrhagic. 44.1% were in acute phase (less than 2 weeks) while 55.9% were in sub-acute (2 weeks to 6 months) phase. Mean score of FMA-UE was 88.63±30.09. The cutoff score/mean value for motor impairment and sensation was recorded as 41.49 ±19.7 and 8.6±3.9 while passive joint motion and pain were calculated 18.93±5.47 and 19.57±5.1 respectively.
Conclusion: The scoring, in acute and subacute phases, accentuate the need to follow Pakistani specific modified norms in Asian inhabitants instead of reference values applicable on western population.
Keywords: Fugl-Meyer scale, Hemiplegia, Motor control, Post Stroke, Upper extremity.
New species of Pavlovophyceae (Haptophyta) and revision of the genera Exanthemachrysis, Rebecca and Pavlova
Authors: Véron Benoît , Rougier Etienne , Taylor Anthony , Goux Didier 
Published: March 2023

The justification of the 4 genera that currently compose the class Pavlovophyceae is based on a low number of species and a relative paucity of available, traceable and referenced cultures. Previous integrative phylogeny work revealed strains that can refine and strengthen our knowledge of the genera in the class. The application of multiple light and electron microscopy techniques allowed us to prioritize the cytomorphological characters (pyrenoid, thylakoid, stigma, knob-scales, life stage / life cycle) used for the taxonomy of these algae and to describe two new species: Exanthemachrysis fresneliae Véron sp. nov. and Rebecca billardiae Véron sp. nov. Consequently, revisions of the two genera Exanthemachrysis Lepailleur emend. Véron and Rebecca Green emend. Véron were made. In addition, the genus Pavlova Butcher emend Véron is revised in the light of these characters. Particular emphasis is placed on the life stages and habitat of the species.
Pengaruh Penggunaan Metode Talaqqi Terhadap Hafalan Qur’an (Juz ‘Amma) Siswa Pada Program Ekstrakurikuler Tahfidz Di SMP-IT Jannatul Firdaus
Authors: Habibah  , Khairuddin YM  
Published: March 2023

Metode yang digunakan dalam proses pembelajaran Al-Qur’an dengan cara murid bertemu atau berhadapan langsung dengan gurunya, sehingga dia memerhatikan langsung bagaimana cara melafazhkan huruf-huruf Al-Quran oleh gurunya, sehingga tajwid dan fasahahnya bagus. Penelitian ini menggunakan pendekatan kuantitatif dengan pendekatan field research. Populasi dalam penelitian ini adalah seluruh siswa sebanyak 160 siswa dan sampel yang diambil sebesar 23 siswa. Penelitian ini dilakukan menggunakan beberapa teknik pengumpulan data yaitu observasi, angket, unjuk kerja, wawancara, dan dokumentasi. Sedangkan analisis datanya dengan menggunakan analisis regresi linier sederhana yaitu terdapat tiga langkah: uji normalitas, uji regresi linear dan uji t. Sebelum melakukan analisis regresi linear sederhana terlebih dahulu data diuji validitas dan reabilitasnya. Penelitian ini memproleh kesimpulan bahwa nilai ????ℎ???????????????????? sebesar 2,343 > (lebihbesar) dari nilai ???????????????????????? 2,080, sehingga dapat disimpulakan bahwa variabel (X) berpengaruh terhadap variabel (Y). Artinya Ho ditolak dan Ha diterima karena ada pengaruh penggunaan metode talaqqi terhadap hafalan Qur’an (Juz ‘Amma) siswa pada program ekstrakurikuler tahfidz di SMP Swasta IT Jannatul Firdaus Desa Perlis Kec. Brandan Barat Kab. Langkat.
Éléments de validation d’une échelle de mesure des connaissances métacognitives liées à la lecture numérique
Authors: Lafontaine Dominique , Jude Nina , Leck Johanna 
Published: March 2023

Cette étude vise à identifier des traces de validité d’une échelle de mesure des connaissances métacognitives de la lecture numérique inédite, développée pour le PISA 2018 et, plus particulièrement, à établir si cette échelle mesure des connaissances relevant de la lecture plutôt que de la littératie numérique. Les données des 37 pays de l’OCDE ont été utilisées. Les résultats montrent que l’échelle de connaissances métacognitives présente une forte corrélation avec les performances en lecture et avec deux échelles ayant subi un processus de validation de la mesure de la métacognition en lecture. Cette échelle est aussi significativement liée à l’intérêt des élèves, à leur concept de soi et à leur sentiment d’efficacité en lecture, mais n’est pas liée avec leur utilisation des TIC, leur intérêt ou leur sentiment d’efficacité perçue dans ce domaine. Les résultats appuient le fait que l’échelle mesure des connaissances relevant de la lecture plutôt que de la littératie numérique et mettent en évidence une corrélation robuste entre les connaissances métacognitives et les performances en lecture.
Élaboration d’un questionnaire d’autoévaluation de la compétence interculturelle des directions d’établissement scolaire de langue française au Québec et au Nouveau-Brunswick
Authors: Gélinas-Proulx Andréanne , Jacquin Philippe , Labelle Jean , Cambron-Prémont Amélie 
Published: March 2023

En cette ère d’inclusion, force est d’admettre que les directions d’établissement scolaire, qui baignent ou non dans un contexte de diversité ethnoculturelle, linguistique et religieuse, ont intérêt à développer leur compétence interculturelle. Or, comment conscientiser les directions et savoir si elles ont développé une telle compétence ? Compte tenu d’un tel enjeu, l’objectif de cet article est de présenter le processus d’élaboration d’un questionnaire d’autoévaluation de la compétence interculturelle des directions d’établissement scolaire de langue française au Québec et au Nouveau-Brunswick, qui comprend 1) la recension de questionnaires portant sur cette compétence, 2) la construction d’une banque d’items, 3) le recueil de preuves basées sur le contenu, 4) l’élaboration de la version préliminaire du questionnaire d’autoévaluation, 5) le prétest et 6) l’accumulation de preuves basées sur la structure interne. Finalement, un questionnaire d’autoévaluation préliminaire de 43 items est proposé. Les limites de la recherche et les retombées de ce questionnaire d’autoévaluation préliminaire sont mentionnées en conclusion.
In vitro and in silico evaluations of actinomycin X2and actinomycin D as potent anti-tuberculosis agents
Authors: Qureshi Kamal Ahmad , Azam Faizul , Fatmi Muhammad Qaiser , Imtiaz Mahrukh , Prajapati Dinesh Kumar , Rai Pankaj Kumar , Jaremko Mariusz , Emwas Abdul-Hamid , Elhassan Gamal Osman 
Published: March 2023

Background
Multidrug-resistant tuberculosis (MDR-TB) is one of the world’s most devastating contagious diseases and is caused by the MDR-Mycobacterium tuberculosis (MDR-Mtb) bacteria. It is therefore essential to identify novel anti-TB drug candidates and target proteins to treat MDR-TB. Here, in vitro and in silico studies were used to investigate the anti-TB potential of two newly sourced actinomycins, actinomycin-X2 (act-X2) and actinomycin-D (act-D), from the Streptomyces smyrnaeus strain UKAQ_23 (isolated from the Jubail industrial city of Saudi Arabia).

Methods
The anti-TB activity of the isolated actinomycins was assessed in vitro using the Mtb H37Ra, Mycobacterium bovis (BCG), and Mtb H37Rv bacterial strains, using the Microplate Alamar Blue Assay (MABA) method. In silico molecular docking studies were conducted using sixteen anti-TB drug target proteins using the AutoDock Vina 1.1.2 tool. The molecular dynamics (MD) simulations for both actinomycins were then performed with the most suitable target proteins, using the GROningen MAchine For Chemical Simulations (GROMACS) simulation software (GROMACS 2020.4), with the Chemistry at HARvard Macromolecular Mechanics 36m (CHARMM36m) forcefield for proteins and the CHARMM General Force Field (CGenFF) for ligands.

Results
In vitro results for the Mtb H37Ra, BCG, and Mtb H37Rv strains showed that act-X2 had minimum inhibitory concentration (MIC) values of 1.56 ± 0.0, 1.56 ± 0.0, and 2.64 ± 0.07 µg/mL and act-D had MIC values of 1.56 ± 0.0, 1.56 ± 0.0, and 1.80 ± 0.24 µg/mL respectively. The in silico molecular docking results showed that protein kinase PknB was the preferred target for both actinomycins, while KasA and pantothenate synthetase were the least preferred targets for act-X2and act-D respectively. The molecular dynamics (MD) results demonstrated that act-X2 and act-D remained stable inside the binding region of PknB throughout the simulation period. The MM/GBSA (Molecular Mechanics/Generalized Born Surface Area) binding energy calculations showed that act-X2 was more potent than act-D.

Conclusion
In conclusion, our results suggest that both actinomycins X2 and D are highly potent anti-TB drug candidates. We show that act-X2is better able to antagonistically interact with the protein kinase PknB target than act-D, and thus has more potential as a new anti-TB drug candidate.