bluuebunny/crossref_metadata_2025_split huggingface dataset:
FORMATION OF TECHNICAL COMPETENCE IN FUTURE SPECIALISTS OF THE FOOD INDUSTRY AS A COMPONENT PROFESSIONAL COMPETENCE
Authors: Dubova Nataliia , Lyulchenko Vyacheslav 
Published: April 2023

The article examines the problem of training a future specialist in the food industry in the system of higher education institutions, and in particular focuses on the formation of technical competence. The relevance of this problem and the main approaches to the problem of the formation of technical competence among future specialists in the food industry in the process of obtaining the “bachelorʼs” level are highlighted and characterized. It is highlighted that the formation of technical competence among future specialists in the food industry is possible when mastering professional and free-choice disciplines with the implementation of competence-based, interdisciplinary and interdisciplinary pedagogical approaches. It has been proven that a successful solution to this problem is possible through the establishment of effective pedagogical conditions and the use of active learning methods for the formation of technical competence in future specialists in the food industry. The formation of technical competence in the future specialist of the food industry, as the main component of professional competence, in the education system of higher education institutions, is possible thanks to the separation of pedagogical conditions and the introduction of an interdisciplinary, interdisciplinary and competence approach. Having analyzed research, scientific literature and the main aspects of the educational process of training future specialists in the specialty 015.37 Professional education, we were able to establish the relevance of the formation of technical competence. The formation of technical competence in the future specialist of the food industry, as the main component of professional competence, in the education system of higher education institutions, is possible thanks to the separation of pedagogical conditions and the introduction of an interdisciplinary, interdisciplinary and competence approach. This pedagogical approach will be a full-fledged guarantee of mastering all components of the professional-pedagogical system and involves mastering technical knowledge, technical concepts, technical understanding and development of technical abilities to perform professional activities.
Keywords: specialist; professional competence; technical competence; educational process; acquirer; institution of higher education; interdisciplinary approach; interdisciplinary approach; competence approach; active methods.
COGNITIVE PROCESS FEATURES OF HIGHER EDUCATION STUDENTS IN THE MODERN INFORMATION ENVIRONMENT
Authors: Melnyk Alla 
Published: April 2023

It is substantiated in the psychological and pedagogical context the necessity of studying the characteristics of the digital generation, which are represented by modern students in accordance with the theory of generations by W. Strauss and N. Howe. It is determined that the cognitive process transformations and psychological characteristics of the individual, which reflect the phenomenon of clip thinking, exacerbate the problems of higher education student professional training. The essence of the phenomenon is the interrupted display of the information flow with a high speed of switching information fragments, without taking into account the connections between them, contributing to the lack of perception integrity of the information content and its reflective assimilation. Its main advantages are the high speed of information processing, dynamism in cognitive activity, accelerated and protective brain reaction to a large amount of information. At the same time, its key disadvantages are interpreted as the inability to perceive a long linear sequence of homogeneous information, including book texts; reduced attention span and lower academic performance and knowledge acquisition; increased inability to isolate the main point or think critically. The main ways of effective pedagogical interaction with students of the digital generation in the educational process are the active use of mobile learning, the combination of high-quality content and interesting interactive elements; computer visualisation of educational information, modification of the presentation format through creolized texts, the introduction of ideas of fragmentary presentation of material with preliminary structuring and its gradual deepening; the introduction of technologies for the development of critical thinking, including the method of “6 journalistic questions”.
Keywords: higher education student; digital generation; cognitive processes; clip thinking; multitasking; reduced attention span; online content; visualization; critical thinking.
Le becfigue, petit passereau de Méditerranée
Authors: Aubaile-Sallenave Françoise 
Published: April 2023

Abstract
Fig-eaters are small passerines of various genus (Sylviidés, Acrocéphalidés et Phylloscopidés); They change their diet in the time of fruits, passing from insectivorous to fructivorous. As a result they get stouter, acquiring a delicious grease which meant they became a target for hunting from Antiquity to the present day resulting in their near extinction. We know a very elaborate, long and precise recipe from Babylon. After the Greeks and Romans, Byzantines and Arabs appreciated and consumed these birds, that were prepared according to various recipes. Nevertheless, in the Arab cultures, two kinds of texts show the interest for those small birds: first, medical and paramedical texts of the hippocratic tradition, and second, texts of cookery books that provide recipes while sometimes quoting physicians. Arab authors attributed aphrodisiacal and medical properties to these small birds, but they also were suspicious of them.

Résumé
Les becfigues sont des petits passereaux de divers genres des Sylviidés, Acrocéphalidés et Phylloscopidés. Ils changent de régime à l’époque des fruits passant d'insectivores à frugivores. Par ce fait ils grossissent et acquièrent une graisse d'un goût délicieux qui les ont fait abondamment rechercher, depuis l'Antiquité, au risque de les faire disparaître. Nous avons déjà une recette très élaborée, longue et précise à Babylone. Après les Grecs et les Romains, les Byzantins et Arabes les ont appréciés et consommés selon des recettes variées. Dans les cultures arabes, cependant, deux sortes de textes montrent l'intérêt porté à ces petits oiseaux. D'une part les textes médicaux et paramédicaux relevant de la tradition hippocratique, d'autre part, les textes des livres de cuisine donnant des recettes, tout en citant parfois les médecins. On attribuait à ces oiseaux des propriétés à la fois aphrodisiaques et médicales, mais on s'en méfiait.
Access and Barriers to Health Services Among Sexual and Gender Minority College Students
Authors: Dermody Sarah 
Published: April 2023

<p>College is a vital time to address mental health and substance use, especially among at-risk populations like sexual and gender minority (SGM) students. The current study compared patterns of mental health symptoms and substance use, access to corresponding resources, and endorsed barriers to accessing services between SGM and non-SGM college students. Data came from 1,892 college students throughout Oregon (72.7% female; 3.6% gender minority [GM]; 21.5% sexual minority [SM]; age 18–60 years old) who completed an online survey about their sexual and gender identity, mental health and substance use symptoms, utilization of campus services, and barriers to accessing such services. Continuous and dichotomous outcomes were compared between SGM subgroups using multiple linear and logistic regressions, respectively, adjusting for sex assigned at birth, year of studies, and race/ethnicity. SGM students reported significantly higher levels of psychological distress than non-SGM counterparts (<em>p</em>s < .05). Compared with non-SM individuals, bi/pansexual students demonstrated greater odds of marijuana use (<em>p</em> < .001) and misuse of prescription drugs (<em>p</em> < .05). Compared with non-SGM students, GM, bi/pansexual, and asexual/different SM identity students had greater odds of using on-campus psychological services <em>(ps</em> < .001). Among those who did not use any services, SGM students reported more barriers to obtaining these services than their non-SGM counterparts. SGM students exhibited disparities in psychological distress, some substance use outcomes, and barriers to obtain services on campus. These findings substantiate the need for additional supports for SGM students’ mental health and substance use on college campuses. (PsycInfo Database Record (c) 2022 APA, all rights reserved)</p>
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Decellularized rat submandibular gland as an alternative scaffold for dental pulp regeneration
Authors: Shi Yuanyuan , Wang Yingxin , Shan Zhaochen , Gao Zhenhua 
Published: April 2023

Introduction: Decellularized extracellular matrix has been recognized as an optimal scaffold for dental pulp regeneration. However, the limited amount of native dental pulp tissue restricts its clinical applications. The submandibular gland shares some basic extracellular matrix components and characteristics with dental pulp. However, whether decellularized submandibular gland extracellular matrix (DSMG) can be used as an alternative scaffold for dental pulp regenerative medicine is unclear.Methods: Thus, we successfully decellularized the whole rat submandibular gland and human dental pulp, and then conducted in vitro and in vivo studies to compare the properties of these two scaffolds for dental pulp regeneration.Results: Our results showed that extracellular matrix of the submandibular gland had great similarities in structure and composition with that of dental pulp. Furthermore, it was confirmed that the DSMG could support adhesion and proliferation of dental pulp stem cells in vitro. In vivo findings revealed that implanted cell-seeded DSMG formed a vascularized dental pulp-like tissue and expressed markers involved in dentinogenesis and angiogenesis.Discussion: In summary, we introduced a novel accessible biological scaffold and validated its effectiveness as an extracellular matrix-based tissue engineering scaffold for dental pulp regenerative therapy.
Intensified biodiesel production from waste cooking oil and flow pattern evolution in small-scale reactors
Authors: Tsaoulidis Dimitrios , Garciadiego-Ortega Eduardo , Angeli Panagiota 
Published: April 2023

In this paper, the transesterification reaction of waste cooking oil (WCO) with methanol using KOH as catalyst to produce biodiesel was performed in a micro-reactor (1 mm ID) using a cross-flow inlet configuration. The effects of different variables such as, methanol-to-oil molar ratio, temperature, catalyst concentration, and residence time on biodiesel yield, as well as the associated flow patterns during the transesterification reaction were investigated and the relationship between flow characteristics and mass transfer performance of the system was examined. The work reveals important aspects and the links between the hydrodynamic behaviour and the mass transfer performance of the intensified reactors. It was found that high yield (&gt;90%) of biodiesel can be achieved in one-stage reaction using cross-flow micro-reactors for a wide range of conditions, i.e., methanol-to-oil molar ratio: 8–14, catalyst concentration: 1.4%–1.8% w/w, temperature: 55°C–60°C, and residence times: 55–75 s.
Decreased macular choriocapillaris in thyroid-associated ophthalmopathy: focusing on chorioretinal folds with and without optic disc edema
Authors: Zeng Peng , Liang Jia-qi , Peng Yuan-yu , Fan Shu-xian , Wang Jing , Zhou Shi-you , Tian Peng , Wang Mei 
Published: April 2023

PurposeThe aim of this study was to evaluate the vessel density (VD) of the macular choriocapillaris (CC) and retina in thyroid-associated ophthalmopathy (TAO) patients with chorioretinal folds (CRFs) with and without optic disc edema (ODE) and the correlations of these characteristics with visual function.MethodThis was a cross-sectional study. Twenty TAO patients with CRFs (35 eyes) and 20 normal subjects (normal group, 40 eyes) were recruited at the Ophthalmology Department of the Sun Yat-sen Memorial Hospital from March 2018 to October 2022. Then, CRF patients were divided into two groups, the ODE and non-ODE groups (NODE), based on the presence or absence of ODE. All the patients underwent optical coherence tomography angiography (OCTA) and the VD of the macular CC and retina was computed. The correlation of VD and visual function was analyzed.ResultsCompared with the normal group, the macular whole-image VD in the retinal superficial layer (SLR-mwiVD: 49.82 ± 3.38 in the normal group, 42.44 ± 5.40 in the NODE group, and 42.51 ± 5.37 in the ODE group), deep layer (DLR-mwiVD: 51.05 ± 6.23 in the normal group, 45.71 ± 6.66 in the NODE group, and 46.31 ± 5.48 in the ODE group), and CC (CC-mwiVD: 70.23 ± 2.47 in the normal group, 68.04 ± 3.73 in the NODE group, and 63.09 ± 6.51 in the ODE group) was decreased in the NODE (all p &lt; 0.05) and ODE group (all p &lt; 0.01). There was no difference in these parameters except CC-mwiVD between the ODE and NODE groups. The CC-mwiVD in the ODE group (63.09 ± 6.51) was significantly reduced compared with that in the NODE group (68.04 ± 3.73, p = 0.004). All these VD parameters were negatively correlated with BCVA, VF-PSD, and P100 latency and positively associated with VF-MD, P100 amplitude, and HRR scores (all p &lt; 0.05).ConclusionsThere was a significant decrease in the VD of the macular CC and retina of patients with CRFs with or without ODE, which was correlated with visual dysfunction. The VD of the macular CC in CRF patients with ODE was significantly reduced compared with that in the NODE group, but similar results were not observed in the retina.
Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity
Authors: Allam Venkata Sita Rama Raju , Waern Ida , Taha Sowsan , Akula Srinivas , Wernersson Sara , Pejler Gunnar 
Published: April 2023

IntroductionAsthma is characterized by an imbalance between proteases and their inhibitors. Hence, an attractive therapeutic option could be to interfere with asthma-associated proteases. Here we exploited this option by assessing the impact of nafamostat, a serine protease inhibitor known to neutralize mast cell tryptase.MethodsNafamostat was administered in a mouse model for asthma based on sensitization by house dust mite (HDM) extract, followed by the assessment of effects on airway hyperreactivity, inflammatory parameters and gene expression.ResultsWe show that nafamostat efficiently suppressed the airway hyperreactivity in HDM-sensitized mice. This was accompanied by reduced infiltration of eosinophils and lymphocytes to the airways, and by lower levels of pro-inflammatory compounds within the airway lumen. Further, nafamostat had a dampening impact on goblet cell hyperplasia and smooth muscle layer thickening in the lungs of HDM-sensitized animals. To obtain deeper insight into the underlying mechanisms, a transcriptomic analysis was conducted. This revealed, as expected, that the HDM sensitization caused an upregulated expression of numerous pro-inflammatory genes. Further, the transcriptomic analysis showed that nafamostat suppressed the levels of multiple pro-inflammatory genes, with a particular impact on genes related to asthma.DiscussionTaken together, this study provides extensive insight into the ameliorating effect of nafamostat on experimental asthma, and our findings can thereby provide a basis for the further evaluation of nafamostat as a potential therapeutic agent in human asthma.
Three doses of a recombinant conjugated SARS-CoV-2 vaccine early after allogeneic hematopoietic stem cell transplantation: predicting indicators of a high serologic response—a prospective, single-arm study
Authors: Barkhordar Maryam , Chahardouli Bahram , Biglari Alireza , Ahmadvand Mohammad , Bahri Tanaz , Alaeddini Farshid , Sharifi Aliabadi Leyla , Noorani Seied Saeid , Bagheri Amiri Fahimeh , Biglari Mohammad , Shemshadi Mohammad Reza , Ghavamzadeh Ardeshir , Vaezi Mohammad 
Published: April 2023

BackgroundAllogeneic hematopoietic stem cell transplant (allo-HSCT) recipients must be vaccinated against SARS-CoV-2 as quickly as possible after transplantation. The difficulty in obtaining recommended SARS-CoV-2 vaccines for allo-HSCT recipients motivated us to utilize an accessible and affordable SARS-CoV-2 vaccine with a recombinant receptor-binding domain (RBD)–tetanus toxoid (TT)-conjugated platform shortly after allo-HSCT in the developing country of Iran.MethodsThis prospective, single-arm study aimed to investigate immunogenicity and its predictors following a three-dose SARS-CoV-2 RBD–TT-conjugated vaccine regimen administered at 4-week (± 1-week) intervals in patients within 3–12 months post allo-HSCT. An immune status ratio (ISR) was measured at baseline and 4 weeks (± 1 week) after each vaccine dose using a semiquantitative immunoassay. Using the median ISR as a cut-off point for immune response intensity, we performed a logistic regression analysis to determine the predictive impact of several baseline factors on the intensity of the serologic response following the third vaccination dose.ResultsThirty-six allo-HSCT recipients, with a mean age of 42.42 years and a median time of 133 days between hematopoietic stem cell transplant (allo-HSCT) and the start of vaccination, were analyzed. Our findings, using the generalized estimating equation (GEE) model, indicated that, compared with the baseline ISR of 1.55 [95% confidence interval (CI) 0.94 to 2.17], the ISR increased significantly during the three-dose SARS-CoV-2 vaccination regimen. The ISR reached 2.32 (95% CI 1.84 to 2.79; p = 0.010) after the second dose and 3.87 (95% CI 3.25 to 4.48; p = 0.001) after the third dose of vaccine, reflecting 69.44% and 91.66% seropositivity, respectively. In a multivariate logistic regression analysis, the female sex of the donor [odds ratio (OR) 8.67; p = 0.028] and a higher level donor ISR at allo-HSCT (OR 3.56; p = 0.050) were the two positive predictors of strong immune response following the third vaccine dose. No serious adverse events (i.e., grades 3 and 4) were observed following the vaccination regimen.ConclusionsWe concluded that early vaccination of allo-HSCT recipients with a three-dose RBD–TT-conjugated SARS-CoV-2 vaccine is safe and could improve the early post-allo-HSCT immune response. We further believe that the pre-allo-HSCT SARS-CoV-2 immunization of donors may enhance post-allo-HSCT seroconversion in allo-HSCT recipients who receive the entire course of the SARS-CoV-2 vaccine during the first year after allo-HSCT.
An artificial intelligence-based approach for identifying rare disease patients using retrospective electronic health records applied for Pompe disease
Authors: Lin Simon , Nateqi Jama , Weingartner-Ortner Rafael , Gruarin Stefanie , Marling Hannes , Pilgram Vinzenz , Lagler Florian B. , Aigner Elmar , Martin Alistair G. 
Published: April 2023

ObjectiveWe retrospectively screened 350,116 electronic health records (EHRs) to identify suspected patients for Pompe disease. Using these suspected patients, we then describe their phenotypical characteristics and estimate the prevalence in the respective population covered by the EHRs.MethodsWe applied Symptoma's Artificial Intelligence-based approach for identifying rare disease patients to retrospective anonymized EHRs provided by the “University Hospital Salzburg” clinic group. Within 1 month, the AI screened 350,116 EHRs reaching back 15 years from five hospitals, and 104 patients were flagged as probable for Pompe disease. Flagged patients were manually reviewed and assessed by generalist and specialist physicians for their likelihood for Pompe disease, from which the performance of the algorithms was evaluated.ResultsOf the 104 patients flagged by the algorithms, generalist physicians found five “diagnosed,” 10 “suspected,” and seven patients with “reduced suspicion.” After feedback from Pompe disease specialist physicians, 19 patients remained clinically plausible for Pompe disease, resulting in a specificity of 18.27% for the AI. Estimating from the remaining plausible patients, the prevalence of Pompe disease for the greater Salzburg region [incl. Bavaria (Germany), Styria (Austria), and Upper Austria (Austria)] was one in every 18,427 people. Phenotypes for patient cohorts with an approximated onset of symptoms above or below 1 year of age were established, which correspond to infantile-onset Pompe disease (IOPD) and late-onset Pompe disease (LOPD), respectively.ConclusionOur study shows the feasibility of Symptoma's AI-based approach for identifying rare disease patients using retrospective EHRs. Via the algorithm's screening of an entire EHR population, a physician had only to manually review 5.47 patients on average to find one suspected candidate. This efficiency is crucial as Pompe disease, while rare, is a progressively debilitating but treatable neuromuscular disease. As such, we demonstrated both the efficiency of the approach and the potential of a scalable solution to the systematic identification of rare disease patients. Thus, similar implementation of this methodology should be encouraged to improve care for all rare disease patients.
Impact of novel agent therapies on immune cell subsets and infectious complications in patients with relapsed/refractory multiple myeloma
Authors: John Lukas , Miah Kaya , Benner Axel , Mai Elias K. , Kriegsmann Katharina , Hundemer Michael , Kaudewitz Dorothee , Müller-Tidow Carsten , Jordan Karin , Goldschmidt Hartmut , Raab Marc S. , Giesen Nicola 
Published: April 2023

IntroductionInfections are a leading cause of morbidity and mortality in patients with multiple myeloma (MM). MethodsTo examine the effects of modern second-generation novel agent therapy on immune cell subsets, in particular CD4+-T-cells, and infectious complications in patients with relapsed/refractory MM (RRMM), we conducted a prospective cohort study in 112 RRMM patients. ResultsSubstantially decreased CD4+-T-cells &lt;200/µl before initiation of relapse therapy were detected in 27.7% of patients and were associated with a higher number of previous lines of therapy. Relapse therapy with carfilzomib or pomalidomide showed a significant further decrease of CD4+-T-cells. All novel agents led to a significant decrease of B-cell counts. Overall, infections were frequent with 21.3% of patients requiring antibacterial therapy within the first 3 months of relapse therapy, 5.6% requiring hospitalization. However, in the setting of standard antimicrobial prophylaxis in RRMM patients with very low CD4+-T-cells, no significant association of CD4+T-cell count and an increased risk of infection could be detected. DiscussionOur findings imply that reduced CD4+-T-cell numbers and infections are common in patients with RRMM. We also demonstrate an association with the number of previous therapies and certain substances suggesting an increased need for personalized prophylaxis strategies for opportunistic infections in this patient cohort.