bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are current warning and responses systems suitable to respond to emerging infectious diseases?
Authors: Fernandez de Cordoba Farini Claudia 
Published: August 2023

Abstract
Socio-economic, environmental and ecological factors, as well as several natural hazards, have repeatedly been shown to drive emerging infectious-disease risk. However, these drivers are largely excluded from surveillance, warning and response systems. This paper identifies, analyses and categorises 64 warning and response systems for infectious diseases. It finds that 80% of them are “reactive” – they wait for disease outbreaks before issuing an alert and implementing mitigating strategies. Only 6% of the warning and response systems were “prevention-centred.” These both monitored and were linked to strategies that addressed drivers of disease emergence and re-emergence. This paper argues that warning systems’ failure to conceptualise emerging infectious diseases as part of an integrated human, animal and environmental system stems from inadequate multi-sectoral collaboration and governance, compounded by barriers to data sharing and integration. This paper reviews existing approaches and frameworks that could help to build and expand prevention-centred warning and response systems. It also makes recommendations to foster multi-sectoral collaboration in governance and warning systems for infectious diseases. This includes proposing solutions to address compartmentalisation in international agreements, developing One Health national focal points and expanding bottom-up initiatives.
An assessment of adaptation measures to enhance wheat productivity under climate change during early, mid and end of 21st century in Indian Punjab
Authors: Prabhjyot-Kaur  , Sandhu S. S. , Kothiyal Shivani , Kaur Jatinder 
Published: August 2023

AbstractCERES-Wheat model was used to simulate wheat yield with ensemble model data for three time slices (2030–2050, 2050–2070 and 2070–2090) and four representative concentration pathway (RCP) scenarios (2.6, 4.5, 6.0 and 8.5) for four agroclimatic zones (ACZs) of Punjab. The study was conducted for wheat cultivars (HD2967 and PBW725) with two adaptation measures, i.e. shift in sowing dates and shift in sowing date plus additional nitrogen doses. The results showed that 24th November was the optimized sowing date and the yield were higher when supplemented with higher N doses (190 and 230 kg/ha). For the three time slices under RCP2.6 scenario, an increase in yield with combined adaptation measures for four ACZs and respectively for cvs. HD2967 and PBW725 ranged 16–32 and 16–33% (ACZII), 11–39 and 22–43% (ACZIII), 8–47 and 20–51% (ACZIV) and 15–32 and 22–42% (ACZV). Similarly, under stabilization scenarios (RCP4.5 and 6.0) the yield increased with combined adaptation measures and respectively for cvs. HD2967 and PBW725 ranged 15–32 and 14–31% (ACZII), 10–40 and 19–52% (ACZIII), 5–44 and 7–53% (ACZIV) and 14–32 and 20–42% (ACZV). The shortening of the maturity period for the two cultivars ranged 24–34 (ACZII), 21–36 (ACZIII), 9–19 (ACZIV) and 21–32 (ACZV) days under the future scenarios. Under the RCP8.5 scenario, the wheat cultivars were unable to yield higher even with combined adaptation measures during the end of 21st century. Thus, wheat would be a sustainable crop option under climate change in the state, if the sowing date was shifted to 24th November and supplemented with higher N dose.
Patterns of experience, expression, and physiology of stress relate to depressive symptoms and self-injurious thoughts and behaviors in adolescents: a person-centered approach
Authors: Carosella Katherine A. , Wiglesworth Andrea , Bendezú Jason José , Brower Rylee , Mirza Salahudeen , Mueller Bryon A. , Cullen Kathryn R. , Klimes-Dougan Bonnie 
Published: August 2023

AbstractBackgroundPreliminary evidence shows that discordance in stress experience, expression, and physiology (EEP) in adolescents is linked to depression, suicidal ideation (SI), non-suicidal self-injury (NSSI), and brain functioning. This study employs person-centered analysis to probe the relationship between stress responses, psychopathology, and neural patterns in female adolescents who are oversampled for engagement in NSSI.MethodsAdolescent females (N = 109, ages 12–17) underwent a social stress test from which self-report measures of stress experience, observer ratings of stress expression, and physiological metrics of stress (via salivary cortisol) were obtained. Multi-trajectory modeling was employed to identify concordant and discordant stress EEP groups. Depressive symptoms, SI and attempt, NSSI engagement, frontal and limbic activation to emotional stimuli, and resting state fronto-limbic connectivity were examined in the EEP groups derived from the multi-trajectory models.ResultsFour groups were identified, three of which demonstrated relatively concordant EEP and one which demonstrated discordant EEP (High Experience-High Expression-Low Physiology). Further, replicating past research, the High Experience-High Expression-Low Physiology discordant group exhibited higher depressive symptoms, SI, suicide attempt, and NSSI episodes (only for sensitivity analyses based on past year) relative to other EEP groups. No significant group differences in brain functioning emerged.ConclusionResults indicate that within-person, multi-level patterns in stress responding capture risk for dysfunction including depression and self-injurious thoughts and behaviors. Further interrogating of system-level stress functioning may better inform assessment and intervention efforts.
Baseline benzodiazepine exposure is associated with greater risk of transition in clinical high-risk for psychosis (CHR-P): a meta-analysis
Authors: Raballo Andrea , Poletti Michele , Preti Antonio 
Published: August 2023

AbstractBackgroundEmerging meta-analytical evidence indicates that baseline exposure to antipsychotics and to antidepressants in individuals at clinical high-risk for psychosis (CHR-P) have opposite prognostic effects as regards imminent transition to psychosis, with antipsychotics associated with higher risk and antidepressants associated with a lower risk in comparison to not-exposed individuals. Despite their common use, baseline exposure to benzodiazepines (BDZ) in CHR-P has surprisingly received poor attention as a potential risk modulator for transition to psychosis. The current systematic review and meta-analysis were performed to fix such a knowledge gap.MethodsSystematic scrutiny of Medline and Cochrane library, performed up to 31 December 2022, searching for English-language studies on CHR-P reporting numeric data about the sample, the transition outcome at a predefined follow-up time and raw data on BDZ baseline exposure in relation to such outcome.ResultsOf 1893 identified records, five studies were included in the systematic review and meta-analysis. The proportion of participants with exposure to BDZ at baseline ranged from 5.5% (one study) to 46.2%, with an average of 16.8%. At the end of the period of observation, i.e., the follow-up as reported in the study, 28.4% [95% confidence interval (CI) 19.7–39.1%] participants developed psychosis among the BDZ-exposed against 9.3% (7.3 to 11.9%) among the controls. CHR-P participants who were already under BDZ treatment at baseline had more than double chance of transition to psychosis than CHR-P participants who were BDZ-naïve. The risk ratio (RR) was 2.42 (95% CI 1.38–4.23) in the common effects model (z = 3.09; p = 0.002), and 2.40 (1.53 to 3.77) in the random-effects model (z = 5.40; p = 0.006; tau-squared = 0.0). There was no relevant heterogeneity: Cochran's Q = 1.49; df = 4; p = 0.828; I2 = 0.0% (95% CI 0.0–79%). Quality was good in four studies.ConclusionsOngoing BDZ exposure at inception in CHR-P is associated with a higher risk of transition to psychosis at follow up. This meta-analytic association, which echoes a similar effect of baseline antipsychotic exposure, plausibly indicates that the clinicians' prescription of pharmacological intervention captures some form of prognostically-relevant information (e.g. an anxiety permeated mental state requiring BDZ prescription) that are not adequately encompassed by current CHR-P categorical criteria.
NOVEL STABILITY CONDITIONS FOR SOME GENERALIZATION OF NICHOLSON’S BLOWFLIES MODEL WITH STOCHASTIC PERTURBATIONS
Authors: SHAIKHET LEONID , ABBAS SYED 
Published: August 2023

AbstractWe consider a generalization of the well-known nonlinear Nicholson blowflies model with stochastic perturbations. Stability in probability of the positive equilibrium of the considered equation is studied. Two types of stability conditions: delay-dependent and delay-independent conditions are obtained, using the method of Lyapunov functionals and the method of linear matrix inequalities. The obtained results are illustrated by numerical simulations by means of some examples. The results are new, and complement the existing ones.
Rice genetic resources for organic agriculture under hill ecology: evaluation and usefulness
Authors: Kapoor Chandan , Raj Chandramani , Avasthe Ravikant , Basandrai Daisy , Pattanayak Arunava K. , Aditya Jay Prakash , Das S. P. , Sharma Vikas , Singh Matber , Singh Shweta 
Published: August 2023

AbstractRice cultivation in hills is challenged by sub-optimum weather conditions, low soil fertility, low temperature and moisture stress which impedes in attaining high productivity. To address this, four studies were carried out at ICAR Sikkim Centre, Gangtok, India to evaluate relative performance of local organic cultivars and conventionally bred varieties under an organic farming system. Conventionally bred varieties yielded significantly higher (45%) than local cultivars under recommended timely sown conditions whereas local cultivars showed superiority in grain yield under late sown conditions coinciding with low temperature during flowering to grain filling. Genotypes did not show significant interaction when organic or conventional production conditions were compared. For grain yield, there was a significant variation for variety × year interaction under organic system. Local organic cultivars had reduced grain yield and associated traits under rainfed upland conditions. Panicles per unit area had a significant positive association with grain yield in all production environments (organic lowland, organic upland, conventional lowland and conventional upland). Overall, the study indicates using local cultivars as donors for specific stress tolerance traits in background of high yielding genotypes to enhance rice yields sustainably under organic system in hills.
Design of a compact sigma slotted dual-mode UWB antenna for wireless body area network applications
Authors: Venkatesh P. , Narmadha T. V. 
Published: August 2023

AbstractThis article presents the design of a novel sigma slotted circular monopole antenna for wireless body area network applications. The design is proceeded with a sigma-shaped slot etched on the circular radiator with Rogers 4003C substrate. The size of the proposed antenna is 30 × 30 × 1 mm3. With partial ground plane, the bandwidth characteristics of the antenna have been enhanced. The designed antenna covers 2–10 GHz of the ultra wideband, thereby providing more than 106% bandwidth. The antenna exhibits high gain values of 1.95, 3.23, 3.46, and 5.95 dB at 2.45, 3.45, 5.8, and 9.5 GHz, respectively. The proposed design operates on off-body mode at 2.45 GHz and on-body mode at 5.8 GHz, thus acting as a dual-mode antenna. To ensure the health and safety measure, specific absorption rate analysis was done for both low and high values of input power and also with Cartesian and cylindrical human arm models. Bending analysis was also done. The time domain parameter group delay was also analyzed for the proposed antenna for on- and off-body scenarios. The prototype was fabricated, and validation of simulation results was done for free space and on-body scenarios.
Mars Global Surveyor’s Mars Orbiter Camera (MOC) Wide‐Angle Images (1999–2006): 1. Data Processing
Authors: Robbins Stuart J. 
Published: August 2023

AbstractEarth‐based telescopes and Mars‐orbiting spacecraft have revealed Mars to be a dynamic body with periodic changes spanning hours to years, and other changes that present no discernible pattern. Understanding these surface and atmospheric variations requires observing and tracking them, and that requires global, consistent image data that spans several years. In support of that goal, the Mars Orbiter Camera Wide Angle “daily global map” images, in both red and blue, have undergone a modern processing with photometric corrections. They have been projected and blended into equirectangular and polar stereographic monochromatic and synthetic three‐color mosaics in intervals of 1 day and ΔLs = 2°, 5°, 10° (approximately 4 days, 10 days, and 2.5 weeks, respectively). The full data set presents three dimensions of Mars—location, time, and color—while ranges or values within each dimension can be combined in different ways, presenting a highly complex interplay for exploration. In this work, the methods to generate the data are presented along with an overview of the data set. In the companion paper (Robbins, 2023a, https://doi.org/10.1029/2022JE007621), several new observations are made along with replication of known, previously described phenomena.
Phases of Enhanced Exhumation During the Cretaceous and Cenozoic Orogenies in the Eastern European Alps: New Insights From Thermochronological Data and Thermokinematic Modeling
Authors: Wölfler Andreas , Wolff Reinhard , Hampel Andrea , Hetzel Ralf , Dunkl István 
Published: August 2023

AbstractAustroalpine nappes in the Eastern European Alps have preserved the record of orogenies in the Cretaceous and Cenozoic but their cooling and exhumation history remains poorly constrained. Here we use low‐temperature thermochronology and thermokinematic modeling to unravel the exhumation history of the Austroalpine nappes in the Gurktal Alps. Our data reveal marked differences between the exhumation of units located at different positions within the nappe stack and relative to the Adriatic indenter. Units located at a high structural level and farther away from the indenter cooled through the zircon fission track closure temperature in the Late Cretaceous and have resided at depths of ≤5–6 km since the Oligocene, as indicated by apatite fission track ages of 35–30 Ma. Thermokinematic modeling constrained that these units experienced enhanced exhumation (∼0.60 km/Ma) between ∼99 and ∼83 Ma due to syn‐ to late‐orogenic Late Cretaceous extension. After a phase of slow exhumation (∼0.02 km/Ma), the exhumation rate increased to ∼0.16 km/Ma at ∼34 Ma due to the onset of the Europe‐Adria collision. In contrast, zircon fission track ages from units at a lower structural level and near the indenter indicate cooling during the Eocene; apatite fission track ages cluster at ∼15 Ma. These units were rapidly exhumed (∼0.76 km/Ma) from ∼44 to ∼39 Ma during an Eocene phase of shortening prior to the Europe‐Adria collision. After slow exhumation (∼0.13 km/Ma) between ∼39 and ∼18 Ma, the exhumation rate increased to ∼0.27 km/Ma in the wake of Miocene escape tectonics in the Eastern Alps.
Downscaling CORDEX Through Deep Learning to Daily 1 km Multivariate Ensemble in Complex Terrain
Authors: Quesada‐Chacón Dánnell , Baño‐Medina Jorge , Barfus Klemens , Bernhofer Christian 
Published: August 2023

AbstractHigh spatio‐temporal resolution near‐surface projected data is vital for climate change impact studies and adaptation. We derived the highest statistically downscaled resolution multivariate ensemble currently available: daily 1 km until the end of the century. Deep learning models were employed to develop transfer functions for precipitation, water vapor pressure, radiation, wind speed, and, maximum, mean and minimum temperature. Perfect prognosis is the particular statistical downscaling methodology applied, using a subset of the ReKIS data set for Saxony as predictands, the ERA5 reanalysis as during‐training predictors and the CORDEX‐EUR11 ensemble as projected predictors. The performance of the transfer functions was validated with the VALUE framework, yielding highly satisfactory results. Particular attention was given to the three major perfect prognosis assumptions, for which several tests were carried out and thoroughly discussed. From the latter, we corroborated their fulfillment to a high degree, thus, the derived projections are considered adequate and relevant for impact modelers. In total, 18 runs for RCP85, 1 for RCP45, and 4 for RCP26 were downscaled under both stochastic and deterministic approaches. This multivariate ensemble could drive more accurate and diverse impact studies in the region. Generally, the projected climatologies are in agreement with coarser resolution projections. Nevertheless, statistical particularities were observed for some projections, thus, a list of caveats for potential users is given. Due to the scalability of the presented methodology, further possible applications with additional datasets are proposed. Lastly, several potential improvement prospects are discussed toward the ideal subsequent iteration of the perfect prognosis statistical downscaling methodology.
Response Analysis on Multi‐Parameters in the 2022 Tonga Volcanic Eruption Using Satellite‐Ground Combined Data
Authors: Jiang Nan , Gao Zhaorui , Xu Yan , Xu Tianhe , Guo Ao , Wu Yuhao , Li Song 
Published: August 2023

AbstractThe Tonga volcano (TVE) erupted with a mass of energy released into the plate and atmosphere, causing variations in the relevant geophysical parameters. Thus, we creatively apply the observations from space‐borne and ground‐based sensors to reveal the characterizations of up to four items (tropospheric response, sea surface temperature (SST), surface deformation, and ionospheric reaction). The results of precipitable water vapor from space‐borne and ground‐based data show that tropospheric response has a trend of rising first, after the volcano event dropping sharply, then recovering to the normal level. The reaction of SST shows a slight rise of 0.5–1°C caused by the incident. Examining ground‐based Global Navigation Satellite System station coordinates illustrates that the volcano eruption causes surface deformations up to 46 cm in the northeast direction. Eventually, for the ionospheric reaction, a similar characterization of the tropospheric response is found in the total electron content variation. These are the first comprehensive analyses showing the impacts of the TVE on multiple types of parameters using both space‐borne and ground‐based data from low to high frequency.
Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis
Authors: Lee Ein , Song Chang-Hyun , Bae Sung-Jin , Ha Ki-Tae , Karki Rajendra 
Published: August 2023

AbstractPyroptosis, apoptosis, necroptosis, and ferroptosis, which are the most well-studied regulated cell death (RCD) pathways, contribute to the clearance of infected or potentially neoplastic cells, highlighting their importance in homeostasis, host defense against pathogens, cancer, and a wide range of other pathologies. Although these four RCD pathways employ distinct molecular and cellular processes, emerging genetic and biochemical studies have suggested remarkable flexibility and crosstalk among them. The crosstalk among pyroptosis, apoptosis and necroptosis pathways is more evident in cellular responses to infection, which has led to the conceptualization of PANoptosis. In this review, we provide a brief overview of the molecular mechanisms of pyroptosis, apoptosis, necroptosis, and ferroptosis and their importance in maintaining homeostasis. We discuss the intricate crosstalk among these RCD pathways and the current evidence supporting PANoptosis, focusing on infectious diseases and cancer. Understanding the fundamental processes of various cell death pathways is crucial to inform the development of new therapeutics against many diseases, including infection, sterile inflammation, and cancer.
After cell death: the molecular machinery of efferocytosis
Authors: Moon Byeongjin , Yang Susumin , Moon Hyunji , Lee Juyeon , Park Daeho 
Published: August 2023

AbstractCells constituting a multicellular organism die in a variety of ways throughout life, and most of them die via apoptosis under normal conditions. The occurrence of apoptosis is especially prevalent during development and in tissues with a high cellular turnover rate, such as the thymus and bone marrow. Interestingly, although the number of apoptotic cells produced daily is known to be innumerable in a healthy adult human body, apoptotic cells are rarely observed. This absence is due to the existence of a cellular process called efferocytosis that efficiently clears apoptotic cells. Studies over the past decades have focused on how phagocytes are able to remove apoptotic cells specifically, swiftly, and continuously, resulting in defined molecular and cellular events. In this review, we will discuss the current understanding of the clearance of apoptotic cells at the molecular level.
Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis
Authors: Yao Fenyong , Huang Shisheng , Liu Jiahui , Tan Chunhua , Xu Mengqi , Wang Dengkui , Huang Maoqing , Zhu Yiyao , Huang Xingxu , He Shuijin 
Published: August 2023

AbstractHaploinsufficient mutation in arginine and glutamine-rich protein 1 (Arglu1), a newly identified pre-mRNA splicing regulator, may be linked to neural developmental disorders associated with mental retardation and epilepsy in human patients, but the underlying causes remain elusive. Here we show that ablation of Arglu1 promotes radial glial cell (RG) detachment from the ventricular zone (VZ), leading to ectopic localized RGs in the mouse embryonic cortex. Although they remain proliferative, ectopic progenitors, as well as progenitors in the VZ, exhibit prolonged mitosis, p53 upregulation and cell apoptosis, leading to reduced neuron production, neuronal loss and microcephaly. RNA seq analysis reveals widespread changes in alternative splicing in the mutant mouse embryonic cortex, preferentially affecting genes involved in neuronal functions. Mdm2 and Mdm4 are found to be alternatively spliced at the exon 3 and exon 5 respectively, leading to absence of the p53-binding domain and nonsense-mediated mRNA decay (NMD) and thus relieve inhibition of p53. Removal of p53 largely rescues the microcephaly caused by deletion of Arglu1. Our findings provide mechanistic insights into cortical malformations of human patients with Arglu1 haploinsufficient mutation.