bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does physical activity moderate the association between shorter leukocyte telomere length and incident coronary heart disease? Data from 54,180 UK Biobank participants
Authors: Xiang Meiruo , Pilling Luke C. , Melzer David , Kirk Ben , Duque Gustavo , Liu Rui , Kuchel George A. , Wood Andrew R. , Metcalf Brad , Diniz Breno S. , Hillsdon Melvyn , Kuo Chia-Ling 
Published: August 2023

AbstractTelomere shortening is a biological aging hallmark. The effect of short telomere length may be targeted by increased physical activity to reduce the risk of multiple aging-related diseases, including coronary heart disease (CHD). The objective was to assess the moderation effect of accelerometer-based physical activity (aPA) on the association between shorter leukocyte telomere length (LTL) relatively in the population sample and incident CHD. Data were from the UK Biobank participants with well-calibrated accelerometer data for at least 6.5 days (n = 54,180). Relative mean LTL at baseline (5–6 years prior to aPA assessment) was measured in T/S ratio, using a multiplex quantitative polymerase chain reaction (qPCR) technology, by comparing the amount of the telomere amplification product (T) to that of a single-copy gene (S). aPA measures included total number of events (at least 10-s continued physical activity > 32 milligravities [mg]), total volume, mean duration, mean intensity, and peak intensity of all events. LTL, aPA measures, and their interactions were associated with incident CHD (mean follow-up 6.8 years) using Cox proportional hazards models adjusting for covariates. Longer LTL (relative to the sample distribution) was associated with reduced incidence of CHD (adjusted hazard ratio [aHR] = 0.94 per standard deviation [SD] increase in LTL, [95% CI, 0.90 to 0.99], P = .010). Incidence of CHD was reduced by higher total volume of aPA (aHR = 0.82 per SD increase in LTL, [95% CI, 0.71 to 0.95], P = .010) but increased by higher total number of events (aHR = 1.11 per SD increase in LTL, [95% CI, 1.02 to 1.21], P = .020) after controlling for other aPA measures and covariates. However, none of the interactions between LTL and aPA measures was statistically significant (P = .171).
Regionalized life cycle inventory data collection and calculation for perennial forage production in Canada: methodological best practices and limitations
Authors: Pogue Sarah J. , Bamber Nicole , Imbeault-Tétreault Hugues , Baudoin Adeline , McPherson Aaron L. , Kega Steven , Tom Madavine , Kröbel Roland , Ominski Kim H. , Beauchemin Karen A. , Grant Brenna , McAllister Tim A. 
Published: August 2023

Abstract
Purpose
In Canada, 95–99% of produced forages are consumed domestically each year, mainly by beef cattle. Despite their importance, their contribution to the Canadian livestock industry and associated ecosystem services has not been investigated. This study developed a life cycle inventory (LCI) of perennial forage production in Canada averaged from 2009 to 2018.

Methods
LCI data were sourced or calculated from up-to-date, regionally resolved sources and models. Inputs to perennial forage production included the following: concrete, steel, and plastic usage; machinery fuel consumption; electricity, natural gas, and water use for irrigation; and synthetic and organic fertilizer, lime, and herbicide use. Assessed emissions included ammonia and nitrous oxide (N2O); carbon dioxide from energy use; herbicide, nitrate, and phosphate losses; and soil carbon accumulation. Results were expressed per metric tonne of harvested perennial forage dry matter at provincial and regional scales—Western Canada [British Columbia (BC), Alberta (AB), Saskatchewan (SK), Manitoba (MB)] and Eastern Canada [Ontario (ON), Québec (QC)].

Results and discussion
Rates of inputs varied, with generally lower nutrient but higher herbicide application in West vs. East. Irrigation was highest in BC, followed by AB and SK; energy consumption was highest in BC and lowest in QC. Higher N2O losses and nutrient losses via leaching and runoff in the East were partially due to greater soil moisture. Although total harvested perennial forage area declined from 6.43 to 5.23 million hectares from 2009 to 2018, these lands continued to accumulate soil carbon. The time period used to calculate average yields affected LCI estimates, as prairie yields were lower 1994–2003/1999–2008 due to drought. Furthermore, soil carbon sequestration estimates were affected by the annual change coefficients employed, underscoring the need for careful interpretation of LCI outputs. Results were compared to other studies and highlighted the importance of the choice of data and methods in creating LCI, and the need for transparency.

Conclusions
This first national LCI of perennial forage production in Canada provides a baseline for LCI inputs and outputs associated with this sector, highlighting provincial and regional differences. Outputs can be used to conduct future life cycle assessments to assess the environmental impacts of forage production and generate recommendations to improve sustainability, and for education and marketing purposes. This study demonstrates methodological best practices for LCI data mining and calculations, within available data and model limitations, thereby identifying gaps and providing a roadmap for other countries or sectors to develop detailed forage LCI.
Transformationsprozesse gestalten und evaluieren: Wirkmodelle als Ansatz um strategische Personalentwicklung mit Organisationsentwicklung zu verbinden
Authors: Berg Ann-Kathleen , Schulte Eva-Maria , Schultz Antonia , Kauffeld Simone 
Published: August 2023

ZusammenfassungAngesichts der Dringlichkeit ökologischer, ökonomische und sozialer Transformationsprozesse in deutschen Unternehmen gewinnen wirksame Personal- und Organisationsentwicklungen zunehmend an Bedeutung. Dieser Beitrag in der Zeitschrift Gruppe. Interaktion. Organisation. (GIO) führt Wirkmodelle als Instrument zur Klärung von Wirkungen von transformativen Personal- und Organisationsentwicklungsmaßnahmen ein. Mithilfe solcher theoriebasierter Evaluationsansätze lässt sich die Wirkweise komplexer Maßnahmen systematisch entwickeln und bewerten. Die Evaluation ermöglicht zudem einen Beitrag zur Gestaltung von Transformationsprozessen auf Mitarbeiterebene, im Unternehmen und der Gesellschaft abzuleiten. Anhand eines Fallbeispiels (Weiterbildungsformat VeränderungsMacher) wurde ein Wirkmodell für eine integrierte Personal- und Organisationsentwicklungsmaßnahme konstruiert und in einem Pilotprojekt mit 16 Fachkräften getestet. Durch induktive und deduktive Interviewanalysen mit Führungskräften (N = 13) wurde die Weiterbildung evaluiert, um den Soll- und Ist-Zustand der Lern- und Kompetenzzuwächse der Fachkräfte zu eruieren und die entwickelte Wirkmodellstruktur zu überprüfen. Deskriptive Daten von teilnehmenden Fachkräften (N = 24) bestätigen die angenommenen Wirkmechanismen dieser transformativen Weiterbildung. Die Ergebnisse werden hinsichtlich der Nützlichkeit von Wirkmodellen und der Contribution Analysis zur Gestaltung und Evaluation von Transformationsprozessen diskutiert. Zudem werden praktische Implikationen für die Anwendung der programmtheoretischen Methoden in Unternehmen aufgezeigt.
Zu heiß für Demokratie? Eine Neubetrachtung Montesquieus politischer Klimatheorie
Authors: Beckstein Martin 
Published: August 2023

ZusammenfassungMontesquieus politische Klimatheorie findet in der Politikwissenschaft wenig Anerkennung. Sie gilt als abwegig. Wenn sie nicht ins Lächerliche gezogen wird, dann vor allem deshalb, weil sie in einer Tradition eurozentrischer und rassistischer Stereotypisierung und Rechtfertigung kolonialer Ungerechtigkeit zu stehen scheint. Eine Neubetrachtung Montesquieus Klimatheorie ist jedoch mindestens aus drei Gründen geboten. Erstens ist die Theorie komplexer und zweitens plausibler als gemeinhin angenommen wird. Drittens wirft sie interessante Fragen über die integrationswissenschaftlichen Herausforderungen politikwissenschaftlicher Forschung sowie den Umgang mit dem anthropogenen Klimawandel auf.
Hydrozoans (Cnidaria) from the estuarine zone of the International Minho River, NW Iberian Peninsula, Atlantic Europe
Authors: de Araújo Costa Dimítri , Antunes Carlos , Rocha Sónia , Gomes Nuno 
Published: August 2023

AbstractIn environmental impact studies conducted in coastal regions, the survey of biodiversity is crucial in areas that are subject to interventions. As the characterization of aquatic invertebrates may indicate important issues that need to be addressed. In this regard, hydrozoans (Class Hydrozoa, Phylum Cnidaria) are recognised as important bioindicators. These organisms are characterized by biradial, tetramerous, or polymerous symmetry, a simple gastrovascular system, and non-cellular mesoglea. The aim of the present study was to perform the first descriptive survey of hydrozoan species found in the estuary of the International Minho River (shared by Portugal and Spain), which is classified as an Important Bird Area and is a site of the Natura 2000 network. Specimens were collected from the tidal marine, brackish and tidal freshwater wetland zones through 1) glass eel fishing bycatch using stow nets at flood tides around the new moon (length of float lines: 10 m; bottom anchored lead line: 15 m; height: 8 m; mesh size: 1–2 mm); 2) beam trawl fishing (bottom trawling for 10 min), including species associated with bivalves; 3) Van Veen grab sampler for sediment sampling; 4) on wood fragments in the saltmarsh of the Coura River (tributary of the Minho River); and 5) individuals on the leaves of aquatic plants. A total of 19 species were identified, four of which were first occurrences for Portugal, six for the mainland coast of the country, and one for Southern Europe [Diphasia fallax (Johnston, 1847)]. Three neotypes are also proposed for the species Hydra viridissima, Hydra oligactis and Gymnangium montagui based on the criteria of the International Commission on Zoological Nomenclature. As these organisms are considered bioindicators, the diversity of the hydrozoan community in the Minho River may indicate good water quality.
A review on the formation and remediations of polychlorinated dibenzo p-dioxins and dibenzo-furans (PCDD/Fs) during thermal processes with a focus on MSW process
Authors: Themba Nomathemba , Sibali Linda L. , Chokwe Tlou B. 
Published: August 2023

Abstract
Polychlorinated dibenzo-p-dioxins and dibenzo-furans (PCDD/Fs) are notorious pollutants classified as persistent organic pollutants (POPs), which even at trace levels can bio-accumulate in the environment and have negative effects on organisms. Due to their adverse health effects, countries around the globe have introduced stringent emission standards to reduce the formation of PCDD/Fs. Using data in the literature over the past two decades (2001 to 2023), this review discussed the PCDD/F emissions from incineration facilities, E-waste recycling, iron sintering, secondary metal smelting plants, and crematories. But the review only focused on pollutants and remediation strategies from the incineration processes. There are two heterogeneous mechanism pathways that lead to the formation of PCDD/Fs, firstly, the De novo phase, using macromolecules of carbon or polycyclic aromatic hydrocarbons to begin the synthesis, and secondly, the condensation reaction beginning with the rearrangement of the molecular structure of the precursor compound. On the remediation strategies, adsorption injections were the most preferred method; however, recent studies reported other strategies such as catalytic filtration systems, an electron beam system, and good combustion practices. This review concluded that a lot has been done to manage and prevent PCDD/F formation efficiently to the level which no longer poses a hazard to human health and the environment.

Graphical abstract
Study on the Mechanism of Eerdun Wurile’s Effects on Post-operative Cognitive Dysfunction by the TLR4/NF-κB Pathway
Authors: Qiao Yun , Li Huiru , Li Yan , Su Enboer , Wang Zhe , Che Limuge , Du Yiri 
Published: August 2023

AbstractThe object of our work was to observe whether the Mongolian medicine Eerdun Wurile (EW) improve postoperative cognitive dysfunction (POCD) by affecting the TLR4/NF-κB. Mice (6–8-week-old male C57BL/6 J) were selected to establish an animal model of POCD by combining intracerebroventricular injection of lipopolysaccharide and nephrectomy; EW formulation and EW basic formulation were administered intra-gastrically for 7 consecutive days. The cognitive performance was assessed by Morris water maze test. H&E staining was examined to detect alterations in hippocampal tissue. Immunohistochemical staining was performed to evaluate MyD88, NF-κB, TLR4, iNOS, and IBA-1 expressions; Western blotting and RT-qPCR were performed to evaluate MyD88, NF-κB, and TLR4. The expressions of IL-6, IL-1β, and TNF-α were evaluated by ELISA. Intracerebroventricular injection of lipopolysaccharide combined with nephrectomy induced cognitive dysfunction in mice, stimulated TLR4/NF-κB and microglia, and promoted the secretion of murine TNF-α, IL-1β, and IL-6. EW formulation and EW basic formulation treatment are able to suppress the TLR4/NF-κB pathway activation and microglia, and the serum cytokine secretions related to proinflammation, and restore the cognitive performance. EW formulation and EW basic formulation can improve POCD in mice, and TLR4/NF-κB pathway seems to be one of the important mechanisms in EW’s improvement of POCD.
Heart Failure with Recovered Ejection Fraction in Patients with Vinculin Loss-of-function Variants
Authors: Zahavich Laura , Akilen Rajadurai , George Kristen , Mital Seema 
Published: August 2023

AbstractPredictors of myocardial recovery in heart failure (HF) are poorly understood. We explored if vinculin (VCL) variants are associated with myocardial recovery in dilated cardiomyopathy (DCM). Six infants with DCM with a VCL loss-of-function (LOF) variant were identified. Median age at diagnosis was 2 months, median LV ejection fraction was 24%, and median LV end-diastolic diameter z-score was 10.8. All patients received HF medications. Five patients (83%) showed normalization of LV function at a median age of 2.7 years. One patient progressed to end-stage HF requiring heart transplant. This case series identified a unique phenotype of HF with reduced ejection fraction at presentation that evolved to HF with recovered EF in over 80% of infant DCM cases with LOF VCL variants. These findings have prognostic implications for counseling and management of VCL-associated DCM and highlight a possible genetic basis for HF with recovered ejection fraction.
Graphical abstract
Die Männerpartei: distinktiver Organisationstypus nur für Rechtsaußenparteien?
Authors: Höhne Benjamin 
Published: August 2023

ZusammenfassungIn der Populismusforschung dient der von Cas Mudde vergleichend herausgearbeitete Begriff der „Männerpartei“ zur Beschreibung rechtspopulistischer Parteien. Daran anknüpfend geht dieser Artikel auf Basis einer quantitativen Befragung aktiver Parteimitglieder im Vorfeld der Bundestagswahl 2017 (N = 7923) der Frage nach, inwiefern dieses Konzept auf die „Alternative für Deutschland“ übertragen werden kann und welche Unterschiede und Gemeinsamkeiten zu den sechs anderen im Deutschen Bundestag vertretenen Parteien bestehen. Während zum Wahlverhalten und zur Programmatik rechtspopulistischer Parteien schon länger internationale Forschungsarbeiten vorliegen, stellt die geschlechtliche Verfasstheit von rechten Parteiorganisationen ein Forschungsdesiderat dar. Die 2013 gegründete AfD ist ein besonders interessanter Forschungsgegenstand, da sie sich vom traditionellen Erscheinungsbild von Rechtsaußenparteien unterscheidet, insbesondere bei ihrer inklusiven innerparteilichen Demokratie sowie ihrer zumeist paritätischen Doppelspitze. Diese Genderanalyse zeigt, dass sich die AfD bei der Mitgliedschaft, den Einstellungen und der Partizipation zumeist von den anderen Parteien unterscheidet. Zwar weisen auch die verglichenen Parteien maskuline Prägungen auf, jedoch in abgeschwächter Intensität. Eine graduelle Differenzierung der AfD von den anderen Parteien erscheint hinsichtlich der Geschlechterdimension daher sinnvoller als eine distinktive. Ausgehend von den empirischen Befunden wird vorgeschlagen, die unpräzise Klassifikation der „Männerpartei“ durch eine mehrdimensionale Typologie zu ersetzen, die relationale Aussagen zur Genderdimension von Parteiorganisationen und deren Anti-Feminismus treffen kann. Diese parteienvergleichende Analyse möchte sowohl zur politikbezogenen Genderforschung als auch zur Parteienforschung, die populistische Parteiorganisationen fokussiert, beitragen.
Social Identity and Online Support Groups: A Qualitative Study with Family Caregivers
Authors: Daynes-Kearney Rosemary , Gallagher Stephen 
Published: August 2023

Abstract
Background
The purpose of this study was to explore whether a sense of collective or shared group identity was developed in one established online social support group for family caregivers and, if so, what did group identification mean for the group members and how was this cultivated in the group.

Methods
Eighteen semi-structured interviews were carried out with members of a family caregiver online support group in Ireland. Inductive and deductive reflexive thematic analysis drawing on the social identity approach (SIA) generated four main themes and several related subthemes.

Results
The first main theme generated was The group are a Tribe and the Tribe gets it, with subthemes: Invisibility as a common experience, my Tribe understands I am more than just a carer and Just being part of the Tribe can be enough. The second main theme generated was the Tribe is a lifeline and life-changing, with related subthemes: Our connection relieves experiences of loneliness and social isolation and Sharing knowledge, experience and support made me feel visible. The third and fourth main themes generated were The leadership of group moderators helped create the Tribe identity and Lessons that can be learnt. These findings are discussed in relation to the social identity approach, social isolation and loneliness.

Conclusions
We concluded that group identity can be cultivated through considered, active and balanced moderation, creating a safe, welcoming and supportive space where family caregivers are able to have fun and seek information, advice and emotional support, which helps relieve loneliness and social isolation.
DNAJB4 suppresses breast cancer progression and promotes tumor immunity by regulating the Hippo signaling pathway
Authors: Chen Yanru , Li Jingjia , Pu Lulan , Hu Jinghua , Fang Lingyu , Zhou Fangfang , Zhang Hongying , Yang Yi , Rong Xinxin , Deng Shishan , Hou Lingmi 
Published: August 2023

Abstract
Purpose
Breast cancer is the most common cancer worldwide. Low DNAJB4 expression levels are strongly correlated with poor prognosis in breast cancer patients. However, the molecular mechanism by which DNAJB4 regulates breast cancer progression is unclear.

Methods
The expression of DNAJB4 was validated in human breast cancer tissues, normal human breast tissues, and breast cancer cell lines. CCK-8, colony-forming, and wound healing assays were used to assess the biological effect of DNAJB4 overexpression on cell proliferation and migration in MCF-7 cell lines. Bioinformatic analysis was used to identify the DNAJB4 related pathways in breast cancer. Epithelial-mesenchymal transition (EMT)-related biomarkers and Hippo pathway components were quantified by Western blots. Luciferase and Western blot assays were used to validate which miRNA regulates DNAJB4. In addition, the effects of DNAJB4 on in vivo tumor growth were assessed in xenograft models.

Results
DNAJB4 was expressed at low levels in human breast cancer tissues and breast cancer cell lines and correlated with poor prognosis. DNAJB4 overexpression significantly inhibited cell proliferation and migration in vitro by activating the Hippo pathway. The dual-luciferase assay showed that hsa-miR-183-5p targeted DNAJB4. Moreover, the effects of DNAJB4 could be reversed by miR-183-5p. In addition, the expression of DNAJB4 was strongly correlated with immune infiltration levels. Notably, DNAJB4 overexpression markedly enhanced CD4 + and CD8 + T cells and reduced PD-L1 levels in 4T1 tumors via the Hippo pathway, which retarded tumor growth in a subcutaneous xenograft tumor mouse model of 4T1 cells.

Conclusions
The present study demonstrated that DNAJB4 overexpression inhibited the malignant biological behavior of breast cancer by regulating the Hippo pathway and tumor immunosuppressive environment.
Synthesis, Biological Activity, and the Effect of Ionization Radiation on the Spectral, XRD, and TGA Analysis of Cu(I), Cu(II), Zn(II), and Cd(II) Complexes
Authors: Aly Samar A. , Hassan Safaa S. , El-Boraey Hanaa A. , Eldourghamy Ayman , Abdalla Ehab M. , Alminderej Fahad M. , Elganzory Hussein H. 
Published: August 2023

AbstractNew complexes of molecular formulae of [Cu(H2L1)I] (B1), [Cu(H2L)2(ClO4)2](B2), [Zn (H2L)2(H2O)]SO4(B3) and [Cd(H2L)Cl]Cl(B4) of ligand N-phenyl-2-(p-tolylglycyl)hydrazine -1-carbothioamide (B) have been prepared and characterized by 1H-NMR, Mass spectra, FT-IR, elemental analyses, molar conductance, UV–visible spectra, magnetic susceptibility measurements, thermogravimetric analysis (TGA/DTG) and X-ray powder diffraction before and after irradiation. Elemental analyses indicate that the metal complexes have 1:1 (metal/ ligand) (B1 and B4) or 1:2 stoichiometry for complexes (B2 and B3). The results confirmed that gamma ray enhanced the stability of irradiated compounds as compared to non-irradiated compounds. XRD patterns proved that increasing the crystallinity of the samples and the particles is in nanosize range before and after gamma irradiation. These studies revealed that Cu(II) and Zn(II) complexes adopted octahedral geometry, and Cu(I) and Cd(II) complexes were found to be tetrahedral. The theoretical conformational structure analyses were performed using density functional theory for ligand and complexes at B3LYP functional with 6–31G basis set for ligand and LANL2DZ basis set for complexes. The ligand (B, A) and complexes (B1–B4) and (A1–A4) before and after irradiated have been tested for their inhibitory effect on the growth of bacteria against gram-positive (Streptococcus pyogenes) and gram-negative (Escherichia coli). Molecular docking investigation proved that the Zn(II) complex had interesting interactions with active site amino acids of topoisomerase II DNA gyrase enzymes (code: 2XCT).
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits and atypical pathological findings treated with corticosteroid and rituximab
Authors: Mori Machi , Tanaka Akihito , Maeda Kayaho , Saito Shoji , Furuhashi Kazuhiro , Maruyama Shoichi 
Published: August 2023

AbstractA 16-year-old girl with fever that appeared after taking the second COVID-19 vaccine presented to the clinic with a serum creatinine of 0.89 mg/dL and C-reactive protein of 6.9 mg/dL. She had proteinuria and microscopic hematuria, with slowly worsening kidney function. Her kidney biopsy showed fibrocellular crescents in seven of nine glomeruli that were observed under light microscopy. Another glomerulus showed endocapillary hypercellularity and mesangial cell proliferation. Electron-dense deposits were significant in the mesangial area, with monoclonal IgG1-κ and C3 deposition by immunofluorescence. The patient was diagnosed with proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) and atypical pathological finding of diffuse crescent formation. The treatment regimen for PGNMID has not yet been established, and the appropriate duration of treatment is unknown. In our case, considering that rituximab acts by binding to CD20 on the surface of B cells through its crystallizable fragment, it was administered in addition to prednisolone, which successfully decreased the proteinuria over time.