bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical power is a key threshold determining the magnitude of post‐exercise hypotension in non‐hypertensive young males
Authors: Lei Tze‐Huan , Wang I‐Lin , Chen Yi‐Ming , Liu Xin‐Hao , Fujii Naoto , Koga Shunsaku , Perry Blake , Mundel Toby , Wang Faming , Cao Yinhang , Dobashi Kohei , Kondo Narihiko , Li Hao‐Yu , Goulding Richie P. 
Published: September 2023

AbstractThe effect of different exercise intensities on the magnitude of post‐exercise hypotension has not been rigorously clarified with respect to the metabolic thresholds that partition discrete exercise intensity domains (i.e., critical power and the gas exchange threshold (GET)). We hypothesized that the magnitude of post‐exercise hypotension would be greater following isocaloric exercise performed above versus below critical power. Twelve non‐hypertensive men completed a ramp incremental exercise test to determine maximal oxygen uptake and the GET, followed by five exhaustive constant load trials to determine critical power and W′ (work available above critical power). Subsequently, criterion trials were performed at four discrete intensities matched for total work performed (i.e., isocaloric) to determine the impact of exercise intensity on post‐exercise hypotension: 10% above critical power (10% > CP), 10% below critical power (10% < CP), 10% above GET (10% > GET) and 10% below GET (10% < GET). The post‐exercise decrease (i.e., the minimum post‐exercise values) in mean arterial (10% > CP: −12.7 ± 8.3 vs. 10% < CP: v3.5 ± 2.9 mmHg), diastolic (10% > CP: −9.6 ± 9.8 vs. 10% < CP: −1.4 ± 5.0 mmHg) and systolic (10% > CP: −23.8 ± 7.0 vs. 10% < CP: −9.9 ± 4.3 mmHg) blood pressures were greater following exercise performed 10% > CP compared to all other trials (all P < 0.01). No effects of exercise intensity on the magnitude of post‐exercise hypotension were observed during exercise performed below critical power (all P > 0.05). Critical power represents a threshold above which the magnitude of post‐exercise hypotension is greatly augmented.
A Dynamic Insulation Technique for Building Envelop by Using Microchannels
Authors: Shafiee Shahin , Dicko Hamed 
Published: September 2023

Abstract
Initially designed for electronic system cooling, microchannels represent innovative technologies that can also be harnessed to augment the thermal resistance of building walls. When employed as an additional insulation layer within the building envelope, they have the potential to replace traditional insulating materials like wool, polystyrene, wood fiber, and cotton denim. This article explores modeling and simulation results pertaining to the performance of microchannels integrated into a standard building wall, aiming to provide dynamic thermal resistance for the building envelope. The simulations were conducted using aluminum microchannels featuring a rectangular profile, and various working fluids (air and water) were considered to assess system performance under different fluid conditions. To ensure laminar flow conditions in both working fluids, the Reynolds number was controlled within the range of 100–900 across multiple runs. The simulation and analysis outcomes underscore the viability of fluid flow through microchannels within building walls as a promising insulation technique capable of delivering dynamic thermal resistance and enhancing energy efficiency across diverse building types. Furthermore, the results emphasize that the utilization of water-based fluid within microchannels outperforms air-based fluid flow, particularly in terms of heat transfer and heat dissipation capabilities.
Semiautomatic Training Load Determination in Endurance Athletes
Authors: Dausin Christophe , Ruiz-Carmona Sergio , De Bosscher Ruben , Janssens Kristel , Herbots Lieven , Heidbuchel Hein , Hespel Peter , Cornelissen Véronique , Willems Rik , La Gerche André , Claessen Guido , _ _ 
Published: September 2023

Background: Despite endurance athletes recording their training data electronically, researchers in sports cardiology rely on questionnaires to quantify training load. This is due to the complexity of quantifying large numbers of training files. We aimed to develop a semiautomatic postprocessing tool to quantify training load in clinical studies. Methods: Training data were collected from two prospective athlete’s heart studies (Master Athlete’s Heart study and Prospective Athlete Heart study). Using in-house developed software, maximal heart rate (MaxHR) and training load were calculated from heart rate monitored during cumulative training sessions. The MaxHR in the lab was compared with the MaxHR in the field. Lucia training impulse score, based on individually based exercise intensity zones, and Edwards training impulse, based on MaxHR in the field, were compared. A questionnaire was used to determine the number of training sessions and training hours per week. Results: Forty-three athletes recorded their training sessions using a chest-worn heart rate monitor and were selected for this analysis. MaxHR in the lab was significantly lower compared with MaxHR in the field (183 ± 12 bpm vs. 188 ± 13 bpm, p < .01), but correlated strongly (r = .81, p < .01) with acceptable limits of agreement (±15.4 bpm). An excellent correlation was found between Lucia training impulse score and Edwards training impulse (r = .92, p < .0001). The quantified number of training sessions and training hours did not correlate with the number of training sessions (r = .20) and training hours (r = −.12) reported by questionnaires. Conclusion: Semiautomatic measurement of training load is feasible in a wide age group. Standard exercise questionnaires are insufficiently accurate in comparison to objective training load quantification.
Protocol for a systematic review and meta-analysis of tobacco-cessation interventions delivered perioperatively
Authors: Harrogate Suzanne R , Barnes Jonathan David , Gupta Swati , Rudd Sarah , Banerjee Trisha , Thomas Kyla , Hinchliffe Robert , Mouton Ronelle 
Published: September 2023

IntroductionTobacco smoking is associated with a substantially increased risk of perioperative complications. The perioperative period is an opportunity to introduce tobacco-cessation strategies. A previous systematic review provided evidence that perioperative interventions increase short-term abstinence and may reduce postoperative complications. The evidence base has since expanded, with the subsequent publication of numerous randomised studies. This protocol outlines a systematic review examining the impact of perioperative tobacco-cessation interventions on successful abstinence from tobacco smoking, and on the incidence of perioperative complications.Methods and analysisA systematic search of the literature will be run across EMBASE (Ovid), MEDLINE (Ovid), CINAHL (Ebsco) and PsycInfo (ProQuest), from inception to present, using text words and subject headings. Randomised controlled trials published in English, examining adults in the perioperative period and reporting the outcomes from tobacco-cessation interventions will be included.Abstract screening and data extraction will be performed by five reviewers. Each abstract will be screened by two blinded reviewers, with discrepancies resolved by group consensus. The primary outcome will be point prevalence abstinence from tobacco-use at the time of surgery. Secondary outcomes are prolonged abstinence from tobacco use at 6 months and 12 months, and postoperative complications. Any other reported outcomes will be documented in the descriptive analysis. The review will also describe details of the investigated perioperative tobacco-cessation interventions. If sufficient studies report relevant data, meta-analysis of the primary and secondary outcomes will be undertaken. Results will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement.Ethics and disseminationNo ethical approval is required. Results will be disseminated by open-access, peer-reviewed journal publication and conference presentations. Results will underpin future work to modify perioperative tobacco-cessation interventions to enhance engagement and accessibility, and to develop trials aiming to facilitate abstinence from tobacco-use in patients presenting for surgery.
Belgian Endothelial Surgical Transplant of the Cornea (BEST cornea) protocol: clinical and patient-reported outcomes of Ultra-Thin Descemet Stripping Automated Endothelial Keratoplasty (UT-DSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK) – a multicentric, randomised, parallel group pragmatic trial in corneal endothelial decompensation
Authors: Ní Dhubhghaill Sorcha , de Bruyn Barbara , Claerhout Ilse , Claes Kim , Deconinck Ann , Delbeke Heleen , Huizing Manon , Krolo Iva , Muijzer Marc , Oellerich Silke , Roels Dimitri , Termote Karolien , Van den Bogerd Bert , Van Gerwen Veerle , Verhaegen Iris , Wisse Robert , Wouters Kristien , Consortium The BEST cornea , Duchesne Bernard , Koppen Carina 
Published: September 2023

ObjectivesCorneal blindness is the third most frequent cause of blindness globally. Damage to the corneal endothelium is a leading indication for corneal transplantation, which is typically performed by lamellar endothelial keratoplasty. There are two conventional surgical techniques: Ultra-Thin Descemet Stripping Automated Endothelial Keratoplasty (UT-DSAEK) and Descemet Membrane Endothelial Keratoplasty (DMEK). The purpose of this study is to compare both techniques.Methods and analysisThe trial compares UT-DSAEK and DMEK in terms of clinical and patient reported outcomes using a pragmatic, parallel, multicentric, randomised controlled trial with 1:1 allocation with a sample size of 220 participants across 11 surgical centres. The primary outcome is the change in best-corrected visual acuity at 12 months. Secondary outcomes include corrected and uncorrected vision, refraction, proportion of high vision, quality of life (EQ-5D-5L and VFQ25), endothelial cell counts and corneal thickness at 3, 6 and 12 months follow-up appointments. Adverse events will also be compared 12 months postoperatively.Ethics and disseminationThe protocol was reviewed by ethical committees of 11 participating centres with the sponsor centre issuing the final definitive approval. The results will be disseminated at clinical conferences, by patient partner groups and open access in peer-reviewed journals.Governance of the trialBoth, trial management group and trial steering committee, are installed with representatives of all stakeholders involved including surgeons, corneal bankers, patients and external experts.Trial registration numberNCT05436665.
Analysis and comparison of clinical practice guidelines regarding treatment recommendations for chronic tinnitus in adults: a systematic review
Authors: Meijers Sebastiaan , Stegeman Inge , van der Leun Josephine A , Assegaf Saloua A , Smit Adriana L 
Published: September 2023

ObjectivesTo determine if, and to what extent, published clinical practice guidelines for the treatment of chronic tinnitus vary in their recommendations.DesignSystematic review of guidelines.Data sourcesPubMed, EMBASE and GIN electronic databases were searched in March 2022 and the search was updated in June 2023.Eligibility criteriaWe included clinical practice guidelines that gave recommendations on the treatment of tinnitus. No language restrictions were applied.Data extraction and synthesisTwo independent reviewers extracted the data and used the AGREE checklist to report on reporting.ResultsA total of 10 guidelines were identified and included, published between 2011 and 2021. Recommendations for 13 types of tinnitus treatments were compared. Large differences in guideline development and methodology were found. Seven of the 10 guidelines included a systematic search of the literature to identify the available evidence. Six of the 10 guidelines used a framework for the development of the guideline. Reporting was poor in multiple guidelines. Counselling and cognitive behavioural therapy were the only treatments that were recommended for treating tinnitus associated distress by all guidelines that reported on these topics. Tinnitus retraining therapy, sound therapy, hearing aids and cochlear implantation were not unanimously recommended either due to the lack of evidence, a high risk of bias or judgement of no beneficial effect of the specific treatment.ConclusionsThere were notable differences with respect to whether guidelines considered the available evidence sufficient enough to make a recommendation. Notably, we identified substantial differences in the rigour of guideline design and development. Reporting was poor in many guidelines. Future guidelines could benefit from the use of reporting tools to improve reporting and transparency and the inclusion of guideline experts and patients to improve the quality of clinical practice guidelines on tinnitus.
Early restricted oxygen therapy after resuscitation from cardiac arrest (ER-OXYTRAC): protocol for a stepped-wedge cluster randomised controlled trial
Authors: Yamamoto Ryo , Yamakawa Kazuma , Endo Akira , Homma Koichiro , Sato Yasunori , Takemura Ryo , Yamagiwa Takeshi , Shimizu Keiki , Kaito Daiki , Yagi Masayuki , Yonemura Taku , Shibusawa Takayuki , Suzuki Ginga , Shoji Takahiro , Miura Naoya , Takahashi Jiro , Narita Chihiro , Kurata Saori , Minami Kazunobu , Wada Takeshi , Fujinami Yoshihisa , Tsubouchi Yohei , Natsukawa Mai , Nagayama Jun , Takayama Wataru , Ishikura Ken , Yokokawa Kyoko , Fujita Yasuo , Nakayama Hirofumi , Tokuyama Hideki , Shinada Kota , Taira Takayuki , Fukui Shoki , Ushio Noritaka , Nakane Masaki , Hoshiyama Eisei , Tampo Akihito , Sageshima Hisako , Takami Hiroki , Iizuka Shinichi , Kikuchi Hitoshi , Hagiwara Jun , Tagami Takashi , Funato Yumi , Sasaki Junichi , ER-OXYTRAC study group 
Published: September 2023

IntroductionCardiac arrest is a critical condition, and patients often experience postcardiac arrest syndrome (PCAS) even after the return of spontaneous circulation (ROSC). Administering a restricted amount of oxygen in the early phase after ROSC has been suggested as a potential therapy for PCAS; however, the optimal target for arterial partial pressure of oxygen or peripheral oxygen saturation (SpO2) to safely and effectively reduce oxygen remains unclear. Therefore, we aimed to validate the efficacy of restricted oxygen treatment with 94%–95% of the target SpO2during the initial 12 hours after ROSC for patients with PCAS.Methods and analysisER-OXYTRAC (early restricted oxygen therapy after resuscitation from cardiac arrest) is a nationwide, multicentre, pragmatic, single-blind, stepped-wedge cluster randomised controlled trial targeting cases of non-traumatic cardiac arrest. This study includes adult patients with out-of-hospital or in-hospital cardiac arrest who achieved ROSC in 39 tertiary centres across Japan, with a target sample size of 1000. Patients whose circulation has returned before hospital arrival and those with cardiac arrest due to intracranial disease or intoxication are excluded. Study participants are assigned to either the restricted oxygen (titration of a fraction of inspired oxygen with 94%–95% of the target SpO2) or the control (98%–100% of the target SpO2) group based on cluster randomisation per institution. The trial intervention continues until 12 hours after ROSC. Other treatments for PCAS, including oxygen administration later than 12 hours, can be determined by the treating physicians. The primary outcome is favourable neurological function, defined as cerebral performance category 1–2 at 90 days after ROSC, to be compared using an intention-to-treat analysis.Ethics and disseminationThis study has been approved by the Institutional Review Board at Keio University School of Medicine (approval number: 20211106). Written informed consent will be obtained from all participants or their legal representatives. Results will be disseminated via publications and presentations.Trial registration numberUMIN Clinical Trials Registry (UMIN000046914).
Arab reactions towards Russo-Ukrainian war
Authors: Tamer Moayadeldin , Khamis Mohamed A. , Yahia Abdallah , Khaled SeifALdin , Ashraf Abdelrahman , Gomaa Walid 
Published: September 2023

AbstractThe aim of this paper is to analyze the Arab peoples reactions and attitudes towards the Russo-Ukraine War through the social media of posted tweets, as a fast means to express opinions. We scrapped over 3 million tweets using some keywords that are related to the war and performed sentiment, emotion, and partiality analyses. For sentiment analysis, we employed a voting technique of several pre-trained Arabic language foundational models. For emotion analysis, we utilized a pre-constructed emotion lexicon. The partiality is analyzed through classifying tweets as being ‘Pro-Russia’, ‘Pro-Ukraine’, or ‘Neither’; and it indicates the bias or empathy towards either of the conflicting parties. This was achieved by constructing a weighted lexicon of n-grams related to either side. We found that the majority of the tweets carried ‘Negative’ sentiment. Emotions were not that obvious with a lot of tweets carrying ‘Mixed Feelings’. The more decisive tweets conveyed either ‘Joy’ or ‘Anger’ emotions. This may be attributed to celebrating victory (‘Joy’) or complaining from destruction (‘Anger’). Finally, for partiality analysis, the amount of tweets classified as being ‘Pro-Ukraine’ was slightly greater than Pro-Russia’ at the beginning of the war (specifically from Feb 2022 till April 2022) then slowly began to decrease until they nearly converged at the start of June 2022 with a shift happening in the empathy towards Russia in August 2022. Our Interpretation for that is with the initial Russian fierce and surprise attack at the beginning and the amount of refugees who escaped to neighboring countries, Ukraine gained much empathy. However, by April 2022, Russian intensity has been decreased and with heavy sanctions the U.S. and West have applied on Russia, Russia has begun to gain such empathy with decrease on the Ukrainian side.
Abstract IA05: Nodal and systemic Immune effects of radiation in HNSCC
Authors: Darragh Laurel B. , Gadwa Jacob , Boss Keara , Karam Sana D. 
Published: September 2023

Abstract
When combined with immunotherapy, HPV-unrelated HNSCC has a high incidence of local and regional recurrence. Since nodal metastasis remains a common pattern of spread for HNSCC, elective nodal irradiation (ENI) is commonly employed to eradicate potential microscopic disease in non-involved lymph nodes. Given our developing understanding that (1) immune cells are highly radio-sensitive, and (2) that anti-tumor T cell priming, and expansion, occur in the draining lymph nodes (DLNs), we tested whether RT directed at gross tumor only could increase the effectiveness of immunotherapies. Using preclinical models and samples from canine and human trials, we tested the effects of RT with or without ENI. Immune cell differences in the tumor tissue, DLNs, and blood were characterized with flow cytometry. We found that tumor only irradiation decreased local and distant tumor growth and increased survival but increased regional recurrence. Sentinel lymph node resection or irradiation was effective at reducing regional metastasis. We show that the effectiveness of tumor only RT is likely mediated via induction of a systemic immune response dependent on antigen recognition by T cells in the DLNs. These data support the hypothesis that effective anti-tumor immunotherapy treatment requires a systemic, antigen-dependent immune response which is primed in the DLNs.
Citation Format: Laurel B. Darragh, Jacob Gadwa, Keara Boss, Sana D. Karam. Nodal and systemic Immune effects of radiation in HNSCC [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Innovating through Basic, Clinical, and Translational Research; 2023 Jul 7-8; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2023;29(18_Suppl):Abstract nr IA05.
Abstract PO-047: A novel saliva miRNA panel of promising diagnostic biomarkers for oral cancer: The association of miR-21 with smoking history
Authors: Vageli Dimitra , Doukas Panagiotis G. , Judson Benjamin L. 
Published: September 2023

Abstract
Introduction: Tobacco use is implicated in the carcinogenesis of oral squamous cell carcinoma (OSCC), which is associated with poor survival if not diagnosed early. It is urgent to develop a novel non-invasive and highly sensitive risk assessment and diagnostic method to screen OSCC. Here, we explored salivary miRNAs as a screening method for OSCC in a high-risk group of patients, such as smokers. Materials and methods: Saliva was collected from 44 individuals (23 HPV-negative OSCC; 21 controls; an equal number of smokers and non-smokers). Twenty head and neck cancer-related miRNA markers were analyzed by qPCR, using dual-labeled probes (miR-20A, miR-21, miR-27B, miR-29A, miR-29B, miR-29C, miR-31, miR-34a, miR-99a, miR-125a, miR-136, miR-139, miR-155, miR-192, miR-200A, miR-375, miR-425A, miR-451a, miR-504, miR-3928; RNU6 control), and by Welch’s t-test and ROC (receiver operating characteristic) curve; GraphPad Prism 7.0. Results: A panel of 4 miRNA markers (miR-21, miR-136, miR-3928, miR-29B) was found to be significantly overexpressed in the saliva of OSCC versus healthy controls with a diagnostic ability (p&lt;0.05 by Welch’s t-test; AUC (area under the ROC curve): 64-85%, sensitivity: 50-67%, specificity: 32-38%; 95% confidence interval; by ROC curve analysis). “Oncomir” miR-21 levels (miR-21/RNU6) were found to be significantly higher in the saliva of OSCC patients with a smoking history (mean ± SD: 0.17 ± 0.19) versus never-smokers (mean ± SD: 0.0056 ± 0.0075) (p&lt;0.05; by t-test) with a diagnostic ability (AUC: 90%, sensitivity: 68%, specificity: 30%; 95% confidence interval). Conclusions: We provide a novel panel of non-invasive, easy-to-apply, and sensitive biomarkers, for the diagnosis of oral cancer, including miR-21 in individuals with a smoking history, encouraging their validation in a large group of head and neck cancer patients.
Citation Format: Dimitra Vageli, Panagiotis G. Doukas, Benjamin L. Judson. A novel saliva miRNA panel of promising diagnostic biomarkers for oral cancer: The association of miR-21 with smoking history [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Innovating through Basic, Clinical, and Translational Research; 2023 Jul 7-8; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2023;29(18_Suppl):Abstract nr PO-047.