bluuebunny/crossref_metadata_2025_split huggingface dataset:
Re-recognize early recurrence of persistent atrial fibrillation
Authors: Fu Kaixuan , Zhu Xuefeng , Chu Hongxia , Zhong Lin , Wang Zhen , Li Wenjing , Wang Chunxiao , Li Jianping , Gong Lei , Wang Guangqiang , Yao Rao , Wang Lihong 
Published: May 2023

AimsFew studies on early recurrence (ER) focused on patients with persistent atrial fibrillation (AF). We aimed to investigate the characteristics and clinical significance of ER in patients with persistent AF after catheter ablation (CA).MethodsA total of 348 consecutive patients who underwent first-time CA for persistent and long-standing persistent AF between January 2019 and May 2022 were investigated.ResultsAbout 5/348 (1.44%) patients who failed to convert to sinus rhythm after CA were excluded. A total of 110/343 (32.1%) patients had ER, in which 98 (89.1%) were persistent and 50.9% occurred in the first 24 h after CA. Compared with the patients without ER, those with ER were more likely to have late recurrence (LR) (92.7% vs. 1.7%, P &lt; 0.001) during a median follow-up of 13 (IQR 6–23) months. ER was the most significant independent predictor for LR (OR 120.5, 95% CI 41.5–349.8, P &lt; 0.001). ER as atrial flutter (AFL) had a lower risk of LR when compared with ER as AF (P = 0.011) and both AF and AFL (P = 0.003). Early intervention of the patient with ER improved the short-term outcomes (P &lt; 0.001), not long-term outcomes. Only 22/251 (8.76%) patients of LR appears among those who had no recurrence in the first month.ConclusionsPatients with persistent AF may not have a blanking period but rather have a risk period. Clinical significance of the blanking period should be given differential treatment between paroxysmal AF and persistent AF.
Hypothyroidism and rheumatoid arthritis: a two-sample Mendelian randomization study
Authors: Gao Yang , Fan Zheng-Rui , Shi Fang-Yuan 
Published: May 2023

BackgroundMeta-analysis of genome-wide association studies (GWAS) data showed that the relationship between hypothyroidism and rheumatoid arthritis (RA) risk remains under debate. This study is conducted to test the causal relationship of hypothyroidism and RA.MethodsA two-sample Mendelian randomization (TSMR) analysis was employed to estimate the causality of hypothyroidism and rheumatoid arthritis in European ancestry and Asian ancestry. Integrating the effects generated by TSMR, functional annotations and noncoding variant prediction framework were applied to analyze and interpret the functional instrument variants (IVs).ResultsThe results of the inverse variance weighted method showed a strong significant causal relationship between hypothyroidism and risk of RA in European ancestry [odds ratio (OR) = 1.96; 95% confidence interval (CI) 1.49, 2.58; p &lt; 0.001]. The outcomes of MR-Egger, weighted median, weighted mode, and simple mode also showed that hypothyroidism was significantly associated with increased risk of RA in European ancestry. The MR-PRESSO method also showed significant results [Outlier-corrected Causal Estimate = 0.70; standard error (SE) = 0.06; p &lt; 0.001]. An independent dataset and an Asian ancestry dataset were applied to estimate and obtain the coincident results. Furthermore, we integrated the effect of variants in TSMR analysis, functional annotations, and prediction methods to pinpoint the single-nucleotide polymorphism (SNP) rs4409785 as one of the causal variants, which suggested that this variant could impact the binding of CTCF-cohesin and play a vital role in immune cells.ConclusionIn this study, we prove that hypothyroidism is significantly causally associated with increased RA risk, which has not been shown in previous studies. Furthermore, we pinpoint the potential causal variants in RA.
Stapled peptide PROTAC induced significantly greater anti-PD-L1 effects than inhibitor in human cervical cancer cells
Authors: Shi Yu-Ying , Wang An-Jin , Liu Xue-Lian , Dai Meng-Yuan , Cai Hong-Bing 
Published: May 2023

IntroductionImmune checkpoint inhibitors (ICIs) are monoclonal antibodies that target immune checkpoints that suppress immune cell activity. Low efficiency and high resistance are currently the main barriers to their clinical application. As a representative technology of targeted protein degradation, proteolysis-targeting chimeras (PROTACs) are considered to have potential for addressing these limitations.MethodsWe synthesized a stapled peptide-based PROTAC (SP-PROTAC) that specifically targeted palmitoyltransferase ZDHHC3 and resulted in the decrease of PD-L1 in human cervical cancer cell lines. Flow cytometry, confocal microscopy, protein immunoblotting, Cellular Thermal Shift Assay (CETSA), and MTT assay analyses were conducted to evaluate the effects of the designed peptide and verify its safety in human cells.ResultsIn cervical cancer celllines C33A and HeLa, the stapled peptide strongly downregulated PD-L1 to &lt; 50% of baseline level at 0.1 μM. DHHC3 expression decreased in both dosedependentand time-dependent manners. MG132, the proteasome inhibitor, can alleviate the SP-PROTAC mediated degradation of PD-L1 in human cancer cells. In a co-culture model of C33A and T cells, treatment with the peptide induced IFN-γ and TNF-α release in a dose-dependent manner by degrading PD-L1. These effects were more significant than that of the PD-L1 inhibitor, BMS-8.ConclusionsCells treated with 0.1 μM of SP-PROTAC or BMS-8 for 4 h revealed that the stapled peptide decreased PD-L1 more effectively than BMS-8. DHHC3-targeting SP-PROTAC decreased PD-L1 in human cervical cancer more effectively than the inhibitor BMS-8.
Safe Discharge Home With Telemedicine of Patients Requiring Nasal Oxygen Therapy After COVID-19
Authors: Dinh Aurélien , Mercier Jean-Christophe , Jaulmes Luc , Artigou Jean-Yves , Juillière Yves , Yordanov Youri , Jourdain Patrick ,   The AP-HP/Universities/INSERM COVID-19 Research Collaboration
Published: May 2023

Introduction: The COVID-19 pandemic created challenges to healthcare systems worldwide. To allow overwhelmed hospitals to focus on the most fragile and severely ill patients, new types of management had to be set up. During the pandemic, patients with COVID-19 from greater Paris area were monitored at home using a web-based remote system called COVIDOM™, using self-administered questionnaires, which triggered alerts to a regional control center. To ease hospital discharge and to prevent hospital from being overwhelmed, patients still requiring low-flow oxygen therapy discharged home were also included in this telemedicine solution. We aim to evaluate the safety of this original management.Methods: We conducted a retrospective multicenter cohort of patients discharged home from hospital after COVID-19 and still requiring nasal oxygen therapy, who were monitored by questionnaire and trained physicians using COVIDOM. During late follow-up, the status of the patients using a Euro-Qol (EQ-5D-5L) questionnaire, and the Medical Research Council (MRC) Dyspnea scale was collected.Results: From March 21st to June 21st 2020, 73 COVID-19 patients still receiving nasal oxygen at hospital discharge were included. Median [Inter-Quartile Range (IQR)] age was 62.0 [52.5–69.0] years, 64.4% were male. Altogether, risk factors were observed in 49/73 (67%) patients, mainly hypertension (35.6%), diabetes mellitus (15.1%) and active neoplasia (11.0%). Among the cohort, 26% of patients were previously managed in ICU. Oxygen therapy was required for a median [IQR] of 20 [16–31] days. No death or urgent unplanned hospitalization were observed during the COVIDOM telemonitoring. During the late follow-up evaluation (6 months after inclusion), the mean EQ-5D-5L questionnaire score was 7.0 ± 1.6, and the mean MRC dyspnea scale was 0.8 ± 1.0, indicating absence of dyspnea. Five patients have died from non-COVID causes.Conclusions: In this preliminary study, early discharge home of patients with severe COVID-19 disease who still required low-oxygen therapy seems to be safe.
Evaluation of single-delay arterial spin labeling-based spatial coefficient of variation and histogram-based parameters in relation to cerebrovascular reserve in patients with Moyamoya disease
Authors: Fahlström Markus , Svedung Wettervik Teodor , Enblad Per , Lewén Anders , Wikström Johan 
Published: May 2023

IntroductionSingle-delay Arterial Spin Labeling (ASL)-based spatial coefficient of variation (CoVCBF) has been suggested as a measure of hemodynamic disturbance in patients with cerebrovascular diseases. However, spatial CoVCBF and other histogram-based parameters such as skewness and kurtosis and the volume of the arterial transit time artefact (ATAvol), has not been evaluated in patients with MMD nor against cerebrovascular reserve (CVR). The aim of this study was to assess whether any associations between spatial CoVCBF, skewness, kurtosis, and ATAvol are present and to analyze any potential associations with CVR, derived from single-delay ASL in patients with MMD.MethodsFifteen MMD patients were included before or after revascularization surgery. Cerebral blood flow (CBF) maps were acquired using pseudo-continuous ASL before, and 5, 15, and 25 min after an intravenous acetazolamide injection. CVRmax was defined as the highest percentual increase in CBF at any of the three post-injection time points. A vascular territory template was spatially normalized to each patient, including the bilateral anterior, middle, and posterior cerebral arteries. All affected anterior and middle cerebral artery regions and all unaffected posterior cerebral artery regions were included, based on Suzuki grading by digital subtraction angiography.ResultsSignificant differences between affected and unaffected regions were found for CBF, CVRmax, and ATAvol. No association was found between CVRmax and any other parameter. High correlations were found between spatial CoVCBF, skewness and ATAvol.ConclusionSpatial CoVCBF derived from single-delay ASL does not correlate with CVR in patients with MMD. Moreover, skewness and kurtosis did not provide additional information of clinical value.
Younger age and induction failure predict outcomes in infant leukemia: 30 years of experience in a tertiary center
Authors: Ochoa-Fernández Bárbara , Galán-Gómez Víctor , Guerra-García Pilar , Sanromán Sonsoles , Martínez Isabel , Bueno David , Mozo Yasmina , Sisinni Luisa , Losantos Itsaso , González Berta , Pérez-Martínez Antonio 
Published: May 2023

ObjectivesThis study aimed to evaluate the characteristics and outcomes of infant patients with leukemia.MethodsA retrospective analysis was conducted in a cohort of 39 patients diagnosed with infant leukemia from 1990 to 2020 who underwent treatment at the pediatric hemato-oncology department of a tertiary hospital in Madrid, Spain.ResultsOf the 588 diagnosed cases of childhood leukemia, 39 (6.6%) cases were infant leukemia. The 5-year event-free survival and the 5-year overall survival were 43.6% (SE 4.1) and 46.5% (SD 24.08), respectively. In a univariate analysis, a younger age at diagnosis was associated with poorer outcomes (p = 0.027), as was induction failure (p = 0.0024). Patients treated with hematopoietic stem cell transplantation had better outcomes than non-transplanted patients (p = 0.001); however, the group comparisons that exclude patients who were unable to undergo transplantation due to refractoriness/relapse or death during treatment showed no significant differences.ConclusionsThe main risk factors that affected survival in our study were an age younger than 6 months and a poor response to induction therapy. It is important to identify poor prognostic factors in this population in order to seek different approaches that could improve outcomes.
Blunted diurnal interleukin-6 rhythm is associated with amygdala emotional hyporeactivity and depression: a modulating role of gene-stressor interactions
Authors: Hakamata Yuko , Hori Hiroaki , Mizukami Shinya , Izawa Shuhei , Yoshida Fuyuko , Moriguchi Yoshiya , Hanakawa Takashi , Inoue Yusuke , Tagaya Hirokuni 
Published: May 2023

BackgroundThe immune system has major roles in the brain and related psychopathology. Disrupted interleukin-6 secretion and aberrant amygdala emotional reactivity are well-documented in stress-related mental disorders. The amygdala regulates psychosocial stress-related interleukin-6 affected by related genes. These led us to comprehensively examine the relationship between interleukin-6, amygdala activity, and stress-related mental symptoms under gene-stressor interactions.MethodsOne hundred eight nonclinical participants with various levels of anxiety/depression underwent magnetic resonance imaging scans during an emotional face task for amygdala activity and saliva collection (at 10-time points across 2 days) for the total output and diurnal patterns of interleukin-6. Gene-stressor interactions between rs1800796 (C/G) and rs2228145 (C/A) and stressful life events for the biobehavioral measures were explored.ResultsThe blunting of interleukin-6 diurnal pattern was associated with hypoactivation of the basolateral amygdala in response to fearful (vs. neutral) faces (t = 3.67, FWE-corrected p = 0.003), and was predominantly observed in individuals with rs1800796 C-allele homozygotes and negative life changes in the past year (F = 19.71, p &lt; 0.001). When considered in a comprehensive model, the diminished diurnal pattern predicted greater depressive symptoms (β = −0.40), modulated by the amygdala hypoactivity (β = 0.36) and rs1800796-stressor interactions (β = −0.41; all p &lt; 0.001).ConclusionHere we show that the blunted interleukin-6 diurnal rhythm predicts depressive symptoms, modulated by amygdala emotional hyporeactivity and gene-stressor interactions. These findings indicate a potential mechanism underlying vulnerability to depressive disorders, suggesting their early detection, prevention, and treatment through the understanding of immune system dysregulation.
Emm type distribution of group A Streptococcus in China during 1990 and 2020: a systematic review and implications for vaccine coverage
Authors: Xiang Caixin , Zhang Jianzhong , Zhao Fei , You Yuanhai 
Published: May 2023

BackgroundThe recent increase of group A Streptococcus (GAS) infections in Europe has aroused global concern. We aim to provide molecular biological data for GAS prevention and control in China by analyzing the temporal shift of emm type.MethodsWe collected studies reporting GAS emm types in China from 1990 to 2020 by PRISMA statement and established a summary database including emm types and literature quality assessment. Based on the database we analyzed the geographic distribution of emm types from 1990 to 2020 and assessed the coverage of the known GAS 30-valent vaccine. Outbreak-associated emm types that had been reported over the past 30 years were also included.Results47 high quality studies were included for a systematic analysis of emm type distribution. This generated a database including totally 12,347 GAS isolates and 85 emm types. Shift of dominant emm type was witnessed during the past 30 years in China. In mainland China, dominant types changed from emm3, emm1, emm4, emm12 in 1990s to emm12 and emm1 in 2000s and 2010s. Hong Kong and Taiwan were dominated by emm12, emm4 and emm1, of which emm4 reduced but emm12 increased in 2010s significantly. From 1990 to 2020, newly found emm types were increasingly reported in various regions of China. The reported 30-valent M protein vaccine covered 26 M types prevalent in China, including all dominant types.
Antibiotic Susceptibility Patterns and Virulence-Associated Factors of Vancomycin-Resistant Enterococcal Isolates from Tertiary Care Hospitals
Authors: Doss Susai backiam Arockia , Duraisamy Senbagam , Karuppaiya Palaniyandi , Balakrishnan Senthilkumar , Chandrasekaran Balaji , Kumarasamy Anbarasu , Raju Amutha 
Published: May 2023

This study explored the prevalence of multi-drug resistance and virulence factors of enterococcal isolates obtained from various clinical specimens (n = 1575) including urine, blood, pus, tissue, catheter, vaginal wash, semen, and endotracheal secretions. Out of 862 enterococcal isolates, 388 (45%), 246 (29%), 120 (14%), and 108 (13%) were identified as Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, and Enterococcus hirae, respectively, using standard morphological and biochemical methods. The antibiotic resistance profile of all these enterococcal isolates was checked using the disc diffusion technique. High-level resistance was observed for benzylpenicillin (70%) and vancomycin (43%) among E. faecalis and E. faecium isolates, respectively. This study also revealed the prevalence of ‘multi-drug resistance (resistant to 3 antibiotic groups)’ among the vancomycin-resistant enterococcal strains, and this was about 11% (n = 91). The virulence determinants associated with vancomycin resistance (VR) were determined phenotypically and genotypically. About 70 and 39% of E. faecalis and E. faecium isolates showed to be positive for all four virulence factors (gelatinase, protease, hemolysin, and biofilm). Among the several virulence genes, gelE was the most common virulence gene with a prevalence rate of 76 and 69% among E. faecalis and E. faecium isolates, respectively. More than 50% of VRE isolates harbored other virulence genes, such esp, asa, ace, and cylA. Similarly, the majority of the VR enterococcal isolates (n = 88/91) harbored vanA gene and none of them harbored vanB gene. These results disclose the importance of VR E. faecalis and E. faecium and the associated virulence factors involved in the persistence of infections in clinical settings.
Tradisi Besahian: Budaya, Religiositas dan Modernisasi dalam Sistem Pertanian Masyarakat Ogan Ilir
Authors: Otoman Otoman , Panorama Maya , Mikail Kiki 
Published: May 2023

This article examines the socio-cultural changes of society in the midst of the currents of globalization. It is assumed that there is a shift in the Besahian tradition in the Malay community of Embacang Ogan Ilir village which has been a social system in agricultural culture. This study aims to analyze the impact of such shifts because of the global influence of Islam and modernization in the agricultural system. The method used is qualitative explanatory with observation techniques, interviews, and documentation studies. The results showed that the Malay community of Embacang village is a community with a socio-cultural and religious background that is quite religious. The Besahian tradition as the culture of the Malay community of Embacang village reflects the values of religiosity influenced by Islam as a religion embraced by all citizens of its community, such as deliberation, help, togetherness, equality, justice, and friendship. The Besahian tradition on it has undergone an evolutive shift because of modernization in the agricultural system. Agricultural machinery technology is not only shifting the role of human labor, which is the fulcrum in the Besahian tradition, but also slowly but surely shifting the religiosity values contained in the tradition.
Peningkatan Konsentrasi Belajar dengan Yoga Anak
Authors: Sofiyanti Ida , Setyowati Heni 
Published: May 2023

Preschool-age children are children aged 3-6 years where in this period physical growth slows down and psychosocial and cognitive growth will increase. During this period, children can develop their curiosity and be able to speak well. Playing is a tool that children use to develop their social relations with other people in their surroundings, so that at this time it requires concentration in learning. Several studies explain that practicing yoga can help children become calmer and more focused, as well as improve children's ability to plan or concentrate on learning. This service is carried out in 3 stages, namely the first stage is the selection of targets for the application of children's yoga, namely at an early age, the second stage is the application of children's yoga, the third stage is the evaluation of activities by measuring the concentration of learning at an early age. Community service activities are going well and smoothly, there is an expansion of the results of community service with the results of previous research where the level of concentration in children's learning is good. It is hoped that activities like this can take place irrationally so that other preschoolers can feel them.

ABSTRAK
Anak usia prasekolah merupakan anak yang berumur 3-6 tahun dimana pada periode ini terjadi pertumbuhan fisik yang menjadi lambat dan pertumbuhan psikososial dan kognitif akan mengalami kenaikan. Periode ini anak dapat mengembangkan rasa ingin tahunya serta mampu berbicara dengan baik. Bermain merupakan alat yang digunakan anak untuk mengembangkan sosialnya terhadap orang lain di lingkungan sekitarnya, sehingga pada masa ini dibutuhkan konsentrasi dalam belajar. Beberapa studi menjelaskan bahwa latihan yoga dapat membantu anak menjadi lebih tenang dan lebih fokus, dan meningkatkan kemampuan anak dalam melakukan perencanaan atau berkonsentrasi dalam belajar. Pengabdian ini dilaksanakan dalam 3 tahap yaitu Tahap Pertama adalah pemilihan sasaran penerapan yoga anak yaitu pada anak usia dini, Tahap kedua adalah penerapan yoga anak, Tahap ketiga adalah evaluasi kegiatan dengan pengukuran konsetrasi belajar pada anak usia dini. Kegiatan pengabdian masyarakat berjalan dengan baik dan lancar, terdapat kesesuaian hasil pengabdian dengan hasil-hasil penelitian terdahulu dimana tingkat konsentrasi belajar pada anak menjadi baik. Diharapkan kegiatan seperti ini dapat berlangsung secara berkesinambungan agar manfaatnya bisa dirasakan oleh anak prasekolah lainnya.
MEDIA SOSIAL SEBAGAI ALAT PEMASARAN DALAM KEPUTUSAN PEMBELIAN SMARTPHONE SAMSUNG
Authors: Sutrisno Exsel Kristianto , Aprillia Ariesya 
Published: May 2023

Berkembangnya teknologi informasi menuntut kita untuk terus mengikuti, di samping itu perlu adanya penunjang bagi kita seperti smartphone yang mana terjadi juga peningkatan pengguna internet di kalangan masyarakat. Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh media sosial sebagai alat pemasaran terhadap keputusan pembelian. Objek penelitian ini yaitu Mahasiswa Program Studi S-1 Manajemen Universitas Kristen Maranatha. Penelitian ini menggunakan metode penelitian kuantitatif. Pengumpulan data menggunakan penelitian survei dengan melakukan penyebaran kuesioner secara online dengan penggunaan skala Likert. Untuk analisis instrumen penelitian menggunakan uji validitas dan reliabilitas, adanya uji asumsi klasik seperti uji normalitas dan heteroskedastisitas. Kemudian teknik analisis data menggunakan uji analisis regresi linier sederhana dan koefisien determinasi (R2). Untuk pengujian hipotesis penelitian menggunakan uji t. Hasil penelitian menunjukkan bahwa adanya pengaruh media sosial sebagai alat pemasaran terhadap keputusan pembelian smartphone Samsung.Â Kata Kunci: pemasaran media sosial; keputusan pembelian; smartphone
CORPORATE GOVERNANCE TERHADAP NILAI PERUSAHAAN PADA BEBERAPA PENELITIAN SKRIPSI PERGURUAN TINGGI, STUDI META ANALISIS
Authors: Putri Arshinta Chandra , Mamamoba Paulus Yusuf , Angelina Angelina , Meiden Carmel 
Published: May 2023

Dengan menggunakan metode sistem meta-analisis, kami melakukan penelitian untuk menentukan dampak Good Corporate Governance terhadap nilai perusahaan, berdasarkan beberapa hipotesis dari mahasiswa Kwik Kian Gie. Nilai perusahaan sebagai variabel terikat adalah harga yang tersedia yang harus dibayarÂ pembeli masa depan ketika menjual perusahaan. Proksi yang digunakan adalah Tobin's Q. Periode penelitian yang digunakan adalah dari tahun 2010 hingga 2019. Teknik pengambilan sampel dilakukan dengan menggunakan metode purpose-driven sampling yang menghasilkan 20 sampel.Â Untuk mengintegrasikan data hasil penelitian disertasi dan mengetahui dampak corporate governance terhadap nilai perusahaan, peneliti melakukan pengujian dengan menggunakan teknik meta-analitik. HasilÂ meta analisis menunjukkan bahwa variabel kepemilikan manajemen, kepemilikan institusional, komite audit, dan ukuran komite berpengaruh terhadap nilai perusahaan. KesimpulanÂ penelitian ini menunjukkan bahwa kepemilikan manajemen, kepemilikan organisasi, ukuran dewan direksi, dan ukuran dewan auditor perusahaan berpengaruh terhadap nilai perusahaan.