bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of tafasitamab with or without lenalidomide added to first-line R-CHOP for DLBCL: the phase 1b First-MIND study
Authors: Belada David , Kopeckova Katerina , Bergua Burgues Juan Miguel , Stevens Don , André Marc , Persona Ernesto Perez , Pichler Petra , Staber Philipp B. , Trneny Marek , Duell Johannes , Waldron-Lynch Maeve , Wagner Steve , Mukhopadhyay Amitava , Dirnberger-Hertweck Maren , Burke John M. , Nowakowski Grzegorz S. 
Published: June 2023

Abstract
Anti-CD19 immunotherapy tafasitamab is used in combination with lenalidomide in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) who are ineligible for autologous stem cell transplant. Open-label, phase 1b, First-MIND study assessed safety and preliminary efficacy of tafasitamab + R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) ± lenalidomide as first-line therapy in patients with DLBCL. From December 2019 to August 2020, 83 adults with untreated DLBCL (International Prognostic Index 2-5) were screened and 66 were randomly assigned (33 per arm) to R-CHOP-tafasitamab (arm T) or R-CHOP-tafasitamab-lenalidomide (arm T/L) for 6 cycles. Primary end point was safety; secondary end points included end-of-treatment (EoT) overall response rate (ORR) and complete response (CR) rate. All patients had ≥1 treatment-emergent adverse event, mostly grade 1 or 2. Grade ≥3 neutropenia and thrombocytopenia occurred, respectively, in 57.6% and 12.1% (arm T) and 84.8% and 36.4% (arm T/L) of patients. Nonhematologic toxicities occurred at similar rates among arms. R-CHOP mean relative dose intensity was ≥89% in both arms. EoT ORR was 75.8% (CR 72.7%) in arm T and 81.8% (CR 66.7%) in arm T/L; best ORR across visits was 90.0% and 93.9%. Eighteen-month duration of response and of CR rates were 72.7% and 74.5% (arm T) and 78.7% and 86.5% (arm T/L); 24-month progression-free and overall survival rates were 72.7% and 90.3% (arm T) and 76.8% and 93.8% (arm T/L). Manageable safety and promising signals of efficacy were observed in both arms. Potential benefit of adding tafasitamab + lenalidomide to R-CHOP is being investigated in phase 3 frontMIND (NCT04824092). This study is registered at www.clinicaltrials.gov as #NCT04134936.
Pre-copulatory choices drive post-copulatory decisions: mechanisms of female control shift across different life stages
Authors: Sentenská Lenka , Scott Catherine E. , Baruffaldi Luciana , Andrade Maydianne C. B. 
Published: June 2023

Abstract
Background
The ‘wallflower’ hypothesis proposes females mate indiscriminately to avoid reproductive delays. Post-copulatory mechanisms may then allow ‘trading up’, favouring paternity of future mates. We tested links between pre- and post-copulatory choice in Latrodectus geometricus female spiders paired sequentially with two males. These females copulate as adults or as subadults and store sperm in paired spermathecae. Choosy adults have a higher risk of delays to reproduction than subadults.

Results
We predicted low pre-copulatory, but high post-copulatory choice at first matings for adults and the opposite for subadults. At second matings, we expected all females would prefer males superior to their first. We found all females mated indiscriminately at their first pairing, but in contrast to subadults, adults usually allowed only a single insertion (leaving one of their paired spermatheca empty); a mechanism of post-copulatory choosiness. Adult-mated females were more likely to remate than subadult-mated females when they became adults, showing a preference for larger males, while subadult-mated females tended to prefer males of greater size-corrected mass.

Conclusions
Our results show that the ‘wallflower’ effect and ‘trading up’ tactics can be utilized at different life stages, allowing females to employ choice even if rejecting males is costly.
Coronary embolism due to probable clinical bioprosthetic aortic valve thrombosis: a case report
Authors: Ananda Roshan A , Zhang Zhihua 
Published: June 2023

Abstract
Background
Coronary embolism is a relatively rare but important non-atherosclerotic cause of acute coronary syndrome, mainly caused by atrial fibrillation and mechanical heart valve thrombosis due to subtherapeutic anticoagulation. There have been increasing reports of bioprosthetic valve thrombosis (BPVT), but thromboembolic events are rare and mainly affect the cerebrovascular system. Coronary embolism is an extremely rare complication of BPVT.

Case presentation
A 64-year-old male presented with non-ST-Elevation myocardial infarction (NSTEMI) to an Australian regional health service. Three years ago, he had undergone Bentall procedure with bioprosthetic aortic valve replacement for severe aortic regurgitation and significant aortic root dilatation. Diagnostic coronary angiography revealed embolic occlusion of first diagonal branch in the absence of underlying atherosclerosis. Prior to NSTEMI presentation, the patient was clinically asymptomatic apart from the progressive increase in transaortic mean pressure gradient on transthoracic echocardiography which was first detected seven months after surgical aortic valve replacement. Transoesophageal echocardiography showed restrictions of the aortic leaflet opening but no evidence of mass or vegetation. After eight weeks of warfarin therapy, the raised aortic valve gradient returned to normal. Lifelong warfarin was prescribed, and patient remained clinically well at 39-month follow-up.

Conclusion
We experienced a case of coronary embolism in a patient with probable BPVT. Reversible bioprosthetic valve hemodynamic deterioration after anticoagulation strongly supports the diagnosis in the absence of histopathology. Early moderate-to-severe hemodynamic valve deterioration warrants further investigations, including cardiac computed tomography and sequential echocardiography, to investigate for probable BPVT and consideration of timely anticoagulation initiation to prevent thromboembolic events.
Primary care physicians' perspectives and challenges on managing multimorbidity for patients with dementia: a Japan–Michigan qualitative comparative study
Authors: Tsunawaki Shinji , Abe Michiko , DeJonckheere Melissa , Cigolle Christine T. , Philips Kristin K. , Rubinstein Ellen B. , Matsuda Masakazu , Fetters Michael D. , Inoue Machiko 
Published: June 2023

AbstractBackgroundMultimorbidity management can be extremely challenging in patients with dementia. This study aimed to elucidate the approaches of primary care physicians in Japan and the United States (US) in managing multimorbidity for patients with dementia and discuss the challenges involved.MethodsThis qualitative study was conducted through one-on-one semi-structured interviews among primary care physicians, 24 each from Japan and Michigan, US. Thematic and content analyses were performed to explore similarities and differences among each country’s data.ResultsPrimary care physicians in Japan and Michigan applied a relaxed adherence to the guidelines for patients’ chronic conditions. Common challenges were the suboptimal consultation time, the insufficient number or ability of care-coordinating professionals, patients’ conditions such as difficulties with self-management, living alone, behavioral issues, and refusal of care support. Unique challenges in Japan were free-access medical systems and not being sure about the patients’ will in end-of-life care. In Michigan, physicians faced challenges in distance and lack of transportation between clinics and patients’ homes and in cases where patients lacked the financial ability to acquire good care.ConclusionsTo improve the quality of care for patients with multimorbidity and dementia, physicians would benefit from optimal time and compensation allocated for this patient group, guidelines for chronic conditions to include information regarding changing priority for older adults with dementia, and the close collaboration of medical and social care and community resources with support of skilled care-coordinating professionals.
Clinical features of COVID-19 among patients with end-stage renal disease on hemodialysis in the context of high vaccination coverage during the omicron surge period: a retrospective cohort study
Authors: Beck Nam-Seon , Song Soomin , Park Taesung , Hong So-Hyeon , Jeong-Eun Jang , Kim Kyoung-Hwan , Im Joung-Il , Hong Sae-Yong 
Published: June 2023

Abstract
Background
We determined the clinical presentation and outcomes of the Omicron variant of severe acute respiratory syndrome coronavirus 2 infection in hemodialysis patients and identified the risk factors for severe coronavirus disease (COVID-19) and mortality in the context of high vaccination coverage.

Methods
This was a retrospective cohort study involving hemodialysis patients who were vaccinated against COVID-19 during March–September 2022, when the Omicron variant was predominant, and the COVID-19 vaccination rate was high. The proportion of people with severe COVID-19 or mortality was evaluated using univariate logistic regression.

Results
Eighty-three (78.3%) patients had asymptomatic/mild symptoms, 10 (9.4%) had moderate symptoms, and 13 (12.3%) had severe symptoms. Six (5.7%) patients required intensive care admission, two (1.9%) required mechanical ventilation, and one (0.9%) was kept on high-flow nasal cannula. Of the five (4.7%) mortality cases, one was directly attributed to COVID-19 and four to pre-existing comorbidities. Risk factors for both severe COVID-19 and mortality were advanced age; number of comorbidities; cardiovascular diseases; increased levels of aspartate transaminase, lactate dehydrogenase, blood urea nitrogen/creatinine ratio, brain natriuretic peptide, and red cell distribution; and decreased levels of hematocrit and albumin. Moreover, the number of COVID-19 vaccinations wasa protective factor against both severe disease and mortality.

Conclusions
Clinical features of hemodialysis patients during the Omicron surge with high COVID-19 vaccination coverage were significant for low mortality. The risk features for severe COVID-19 or mortality were similar to those in the pre-Omicron period in the context of low vaccination coverage.
Neoadjuvant chemotherapy with modified FOLFOXIRI for locally advanced rectal cancer to transform effectively EMVI and MRF from positive to negative: results of a long-term single center phase 2 clinical trial
Authors: Zhang Wen , Zhou Haitao , Jiang Jun , Zhu Yuelu , Zou Shuangmei , Jiang Liming , Tang Yuan , Liang Jianwei , Sun Yongkun , Jiang Zhichao , Qu Wang , Li Ying , Zhou Aiping 
Published: June 2023

Abstract
Purpose
Chemoradiotherapy (CRT) remains the standard treatment for locally advanced rectal cancer (LARC). This phase 2 clinical trial was designed to evaluate the efficacy and safety of neoadjuvant triplet chemotherapy with mFOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin, and irinotecan) in LARC.

Patients and methods
The patients with LARC (the lower edge more than 5 cm from the anal verge) received up to 5 cycles of mFOLFOXIRI. MRI was performed to assess the baseline and postchemotherapy TN stage. Radical resection was performed within 4–6 weeks from the last dose of chemotherapy if the tumor shrank or remained stable. Adjuvant chemotherapy with mFOLFOX6 or XELOX was recommended. Postoperative radiation was planned for R1 resection, ypT4b, ypN2 and a positive CRM. The primary endpoint was the pathological complete response (pCR) rate.

Results
From February 2016 to March 2019, 50 patients were enrolled. Forty-eight (96%) were clinically node-positive, 28 (56.5%) with MRF invasion and 39 (78.4%) were EMVI positive. The median cycle of neoadjuvant mFOLFOXIRI chemotherapy was 5 (range,1–5). A total of 46/50 (92%) patients underwent total mesorectal excision (TME) surgery, all with R0 resection. The pCR rate was 4.3% (2/46). Twenty-three of 46 (50%) patients with cN + achieved a pathological node-negative status. The proportions of pathologically positive CRM and EMVI were 2.2% and 34.7%, respectively. Adjuvant radiotherapy was given to 14/46 (30.4%) patients. The most common Grade 3 or > toxicities included neutrocytopenia (50%), leukopenia (14%) and diarrhea (12%) during the neoadjuvant chemotherapy period. Clinically meaningful postoperative complications included pneumonia (n = 1), pelvic infection (n = 1) and anastomotic fistula (n = 1). With a median follow-up time of 51.2 months, local recurrences and distant metastases were confirmed in 3 (6.5%) and 9 (19.6%) of cases, respectively. The 3-year disease free survival (DFS) and overall survival (OS)rates were 75.8% and 86.8%.

Conclusion
Neoadjuvant chemotherapy with mFOLFOXIRI yielded a significant down-staging effect and seemed to be effective in eliminating EMVI and transforming the positive MRF to negative in LARC. The survival results are promising. The long-term follow-up showed promising DFS and OS rates accompanied by a favorable safety profile.

Trial registration
ClinicalTrials.gov identifier: NCT03443661, 23/02/2018.
The safety and effectiveness of a novel annular keratopigmentation technique; a cross-sectional survey of patients
Authors: Alafaleq Munirah , van Haselen Robert , Ferrari Francis 
Published: June 2023

Abstract
Purpose
We investigated safety aspects and other patient experiences related to a novel Femtosecond Laser Assisted Annular Keratopigmentation technique (FLAAK).

Setting
Espace Nouvelle Vision Clinic in Paris.

Methods
Monocentric, post-operative, cross-sectional survey of patients who returned to the clinic for a color correction after the FLAAK procedure. Whilst waiting for their color retouch, consenting patients completed a questionnaire about their experiences following the FLAAK procedure. Aspects related to side-effects or discomfort as well as patient satisfaction were assessed.

Results
The questionnaire was completed by 42 of 51 patients returning to the clinic for a color retouch (27 females, 15 males; mean age 37.6 years). Pain was experienced by 34 (81%) patients, dry eyes by 32 (76%) patients, glare by 23 (56%) patients, red eyes by 28 (67%) patients, and tingling by 30 (71%) patients; no patient experienced visual halos. All experienced post-operative symptoms were of a transient nature. Symptoms like pain, tingling, glare and red eyes disappear in less than 48 h after surgery in approximately 50% of the cases, and ocular dryness in 22% of cases., The median duration of these symptoms in patients for whom the symptoms were still present after 48 h, is 7 days. Patient satisfaction with the aesthetical result (scale ranging from 0 to 10) was on average 8,1 (SD 1,6).

Conclusion
The FLAAK procedure performed for purely aesthetic purposes appears to be safe and is associated with high patient satisfaction.
The risk of obstructive sleep apnea is highly correlated with depressive symptoms among the Korean adults population: results from the 2020 Korea National Health and Nutrition Examination Survey
Authors: Lee Mi-Sun , Lee Hooyeon 
Published: June 2023

Abstract
Objectives
We aimed to examine the association between Obstructive Sleep Apnea (OSA) risk, health behaviors, and depressive symptoms in a representative Korean sample.

Methods
Cross-sectional data from the 2020 Korea National Health and Nutrition Examination Survey (KNHANES) were analyzed. The sample included 4,352 adults aged 40 years and older. Multiple linear regression analysis was performed to examine the association between OSA risk, health behaviors, and depressive symptoms.

Results
In total, 23.1% of the participants reported a high risk of OSA. Of the respondents, 39.8%, 19.0%, 27.2%, and 8.7% reported hypertension, snoring, tiredness, and observed apnea, respectively. The prevalence of moderate-severe depressive symptoms among adults with high-risk OSA was 7.5%. The significant associations between OSA risk and sex with PHQ-9 were shown in univariate linear regression. In the multiple linear regression analysis, the association between high risk of OSA and PHQ-9 showed in total (B = 1.58; P < 0.001), male (B = 1.21; P < 0.001), and female (B = 1.93; P < 0.001).

Conclusions
A high risk of OSA was associated with an increased prevalence of depressive symptoms. Monitoring the risk factors of depressive symptoms, including OSA, or unhealthy behaviors may decrease the mental health issues of middle-aged and older adults.
Community Wise—effects and participant perceptions of a community- based -positive health intervention for older inhabitants of low SES neighbourhoods: a mixed-methods approach
Authors: Platzer Feline , Steverink Nardi , Haan Marieke , Vorstman Jiska , de Greef Mathieu , Goedendorp Martine 
Published: June 2023

Abstract
Background
The Community Wise (CW) intervention applies a community-based approach to improve the physical fitness, self-management ability, loneliness, social cohesion, and well-being of older adults living in neighbourhoods characterized by lower socioeconomic status (SES).

Methods
Participants (N = 108) were recruited using several strategies, including door-to-door visits and community key peers. The study was based on a pre-test/post-test design. Outcomes were assessed through mixed methods using questionnaires, performance tests, semi-structured interviews, and focus-group sessions.

Results
Results showed significant improvements on aerobic endurance and shoulder flexibility, but no significant improvements on self-management ability, social cohesion, loneliness, or well-being. Qualitative data analysis did indicate that participants experienced improvements on social connectedness with members of the group, as well as on self-management ability.

Conclusion
The results of the intervention seem to depend on programme fidelity and method of assessment. Adapting the intervention and including more older adults with poor health status could lead to better outcomes in the future. This results of this study should be interpreted in light of the complexity and methodological challenges of conducting a community-based health-promotion intervention for this target group.

Trail registration
Retrospective registration.
A network analysis of subjective well-being in Chinese high school students
Authors: Wang Shiwei , Zhao Siqi , Guo Yan , Huang Chengjing , Zhang Pei , She Lu , Xiang Bing , Zeng Jing , Zhou Feng , Xie Xinyan , Yang Mei 
Published: June 2023

Abstract
Background
The psychological situation of high school students during adolescence is not promising, and the most obvious manifestation is the lack of subjective well-being (SWB). This network analysis presents a model of the interaction and correlation between different items of SWB, identifying the most central items for high school students.

Methods
Through offline and online surveys, 4,378 questionnaires were sent out and finally 4,282 Chinese high school students were available. The response rate was 97.807%. The study used the eLASSO method to estimate the network structure and centrality measures. This algorithm used the EBIC to select the best neighbor factor for each node.

Results
The average age for high school students was 16.320 years old and the average SWB score was 76.680. The distribution of SWB between male and female students was significant different (P < 0.001). S8 (Have you been anxious, worried, or upset) was the node with the highest strength and expected influence. The network structure and centrality remained stable after discarding 75% of the sample at random. Except for S15 (How concerned or worried about your health have you been), all nodes were positively correlated with each other (P < 0.01). The network structure of SWB was similar for female and male students (network strength: 8.482 for male participants; 8.323 for female participants; P = 0.159), as well as for rural and urban students (network strength: 8.500 for rural students; 8.315 for urban students; P = 0.140).

Conclusion
Targeting S8 (Have you been anxious, worried, or upset) as a potential intervention target may increase high school students’ SWB effectively.
School closures and well-being-related topic searches on Google during the COVID-19 pandemic in Sub-Saharan Africa
Authors: Anaduaka Uchechi Shirley , Oladosu Ayomide Oluwaseyi 
Published: June 2023

AbstractBackgroundFollowing the outbreak of the 2020 coronavirus, governments adopted non-pharmaceutical interventions (NPIs) to save lives. The NPIs have been deemed to have unintended consequences on mental health and well-being. This study aimed to estimate the impact of the COVID-19 pandemic-induced school closures on the relative search volumes (RSVs) of well-being-relevant topics in 30 low and lower- middle income countries in Sub-Saharan Africa.MethodsGoogle Trends search data, difference-in-differences and event study methods were used to evaluate the impact on the related search volume (RSV) of well-being related topic queries in Sub-Saharan Africa.ResultsThe results suggest positive and significant increases in the search intensity for anger, boredom, fear, sleep, exercise, and prayer. Contrary to other studies, we find no discernible effects on the relative search volumes (RSVs) on loneliness, sadness, and suicide.ConclusionOur findings suggest that the pandemic and the associated restrictions had a mixed effect on well-being-related searches. We recommend increased vigilance and proactive communication from the government and policy makers with the general population in times of emergencies when social policies that restrict lives and liberties need to be adopted.
Association of Ureaplasma infection pattern and azithromycin treatment effect with bronchopulmonary dysplasia in Ureaplasma positive infants: a cohort study
Authors: Chen Xueyu , Huang Xuemei , Lin Yanqing , Lin Bingchun , Yang Chunyu , Huang Zhifeng , Yang Chuanzhong 
Published: June 2023

Abstract
Background
It is unclear whether Ureaplasma-associated pneumonia and azithromycin treatment affect the risk for bronchopulmonary dysplasia (BPD).

Methods
A retrospective cohort study was performed in very low birth weight (VLBW) infants who tested positive for Ureaplasma within 72 h after birth in a tertiary unit. Chest X-ray (CXR) and laboratory test were performed before and after azithromycin treatment. Multivariate logistic regression analysis was used to identify the independent association between BPD and Ureaplasma-associated pneumonia, as well as BPD and effective azithromycin treatment.

Results
A total of 118 infants were included in the current study, of whom 36 developed BPD (defined as supplemental oxygen needed at postmenstrual age 36 weeks or discharge). The rate of BPD was significantly higher in infants with Ureaplasma-associated pneumonia (44.6%) compared to infants with Ureaplasma colonization (17.7%, P = 0.002). After adjusting for confounders, an effective azithromycin treatment was significantly associated with reduced risk of BPD [odd ratio (OR) 0.011; 95% confidence interval (CI): 0.000–0.250), whereas Ureaplasma-associated pneumonia was not significantly associated with BPD (OR 1.835; 95% CI: 0.548–6.147).

Conclusion
Effective Azithromycin treatment in Ureaplasma positive VLBW infants was associated with a reduced risk of BPD.