bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global trends of traditional Chinese exercises for musculoskeletal disorders treatment research from 2000 to 2022: A bibliometric analysis
Authors: Guan Chong , Gu Yuanjia , Cheng Ziji , Xie Fangfang , Yao Fei 
Published: February 2023

BackgroundTraditional Chinese exercise has been shown to be effective in relieving long-term chronic pain, physical dysfunction, decreased ability to participate in society and decreased quality of life in musculoskeletal diseases. In recent years, there has been a steady increase in publications on the treatment of musculoskeletal disorders by traditional Chinese exercises. The purpose of this study is to review the characteristics and trends of Chinese traditional exercise studies on musculoskeletal diseases published since 2000 through bibliometric analysis, and identify current research hotspots, so as to guide the direction of future research.MethodsPublications regarding traditional Chinese exercises for musculoskeletal disorders from 2000 to 2022 were downloaded from the Web of Science Core Collection. VOSviewer 1.6.18 and CiteSpace V software were used for bibliometric analyses. Bibliometric visualization and comparative analysis were conducted for authors, cited authors, journals, co-cited journals, institutions, countries, references, and keywords.ResultsA total of 432 articles were obtained, with an upward trend over time. The most productive countries and institutions in this field are the USA (183) and Harvard University (70). Evidence-based Complementary and Alternative Medicine (20) was the most prolific journal, Cochrane Database System Review (758) was the most commonly cited journal. Wang Chenchen published the largest number of articles (18). According to high frequency keywords, the hot spot musculoskeletal disorder and the type of traditional Chinese exercise are knee osteoarthritis and Tai Chi.ConclusionThis study provides a scientific perspective for the research of traditional Chinese exercises for musculoskeletal disorders and provides valuable information for researchers to discover the current research status, hot spots and new trends of future research.
Prior knowledge-based precise diagnosis of blend sign from head computed tomography
Authors: Wang Chen , Yu Jiefu , Zhong Jiang , Han Shuai , Qi Yafei , Fang Bin , Li Xue 
Published: February 2023

IntroductionAutomated diagnosis of intracranial hemorrhage on head computed tomography (CT) plays a decisive role in clinical management. This paper presents a prior knowledge-based precise diagnosis of blend sign network from head CT scans.MethodWe employ the object detection task as an auxiliary task in addition to the classification task, which could incorporate the hemorrhage location as prior knowledge into the detection framework. The auxiliary task could help the model pay more attention to the regions with hemorrhage, which is beneficial for distinguishing the blend sign. Furthermore, we propose a self-knowledge distillation strategy to deal with inaccuracy annotations.ResultsIn the experiment, we retrospectively collected 1749 anonymous non-contrast head CT scans from the First Affiliated Hospital of China Medical University. The dataset contains three categories: no intracranial hemorrhage (non-ICH), normal intracranial hemorrhage (normal ICH), and blend sign. The experimental results demonstrate that our method performs better than other methods.DiscussionOur method has the potential to assist less-experienced head CT interpreters, reduce radiologists' workload, and improve efficiency in natural clinical settings.
A 1-Tesla MRI system for dedicated brain imaging in the neonatal intensive care unit
Authors: Berson Elisa R. , Mozayan Ali , Peterec Steven , Taylor Sarah N. , Bamford Nigel S. , Ment Laura R. , Rowe Erin , Lisse Sean , Ehrlich Lauren , Silva Cicero T. , Goodman T. Rob , Payabvash Seyedmehdi 
Published: February 2023

ObjectiveTo assess the feasibility of a point-of-care 1-Tesla MRI for identification of intracranial pathologies within neonatal intensive care units (NICUs).MethodsClinical findings and point-of-care 1-Tesla MRI imaging findings of NICU patients (1/2021 to 6/2022) were evaluated and compared with other imaging modalities when available.ResultsA total of 60 infants had point-of-care 1-Tesla MRI; one scan was incompletely terminated due to motion. The average gestational age at scan time was 38.5 ± 2.3 weeks. Transcranial ultrasound (n = 46), 3-Tesla MRI (n = 3), or both (n = 4) were available for comparison in 53 (88%) infants. The most common indications for point-of-care 1-Tesla MRI were term corrected age scan for extremely preterm neonates (born at greater than 28 weeks gestation age, 42%), intraventricular hemorrhage (IVH) follow-up (33%), and suspected hypoxic injury (18%). The point-of-care 1-Tesla scan could identify ischemic lesions in two infants with suspected hypoxic injury, confirmed by follow-up 3-Tesla MRI. Using 3-Tesla MRI, two lesions were identified that were not visualized on point-of-care 1-Tesla scan: (1) punctate parenchymal injury versus microhemorrhage; and (2) small layering IVH in an incomplete point-of-care 1-Tesla MRI with only DWI/ADC series, but detectable on the follow-up 3-Tesla ADC series. However, point-of-care 1-Tesla MRI could identify parenchymal microhemorrhages, which were not visualized on ultrasound.ConclusionAlthough limited by field strength, pulse sequences, and patient weight (4.5 kg)/head circumference (38 cm) restrictions, the Embrace® point-of-care 1-Tesla MRI can identify clinically relevant intracranial pathologies in infants within a NICU setting.
Ferroptosis-related genes are involved in asthma and regulate the immune microenvironment
Authors: Wang Haixia , Jia Yuanmin , Gu Junlian , Chen Ou , Yue Shouwei 
Published: February 2023

Background: Asthma was a chronic inflammatory illness driven by complicated genetic regulation and environmental exposure. The complex pathophysiology of asthma has not been fully understood. Ferroptosis was involved in inflammation and infection. However, the effect of ferroptosis on asthma was still unclear. The study was designed to identify ferroptosis-related genes in asthma, providing potential therapeutic targets.Methods: We conducted a comprehensive analysis combined with WGCNA, PPI, GO, KEGG, and CIBERSORT methods to identify ferroptosis-related genes that were associated with asthma and regulated the immune microenvironment in GSE147878 from the GEO. The results of this study were validated in GSE143303 and GSE27066, and the hub genes related to ferroptosis were further verified by immunofluorescence and RT-qPCR in the OVA asthma model.Results: 60 asthmatics and 13 healthy controls were extracted for WGCNA. We found that genes in the black module (r = −0.47, p &lt; 0.05) and magenta module (r = 0.51, p &lt; 0.05) were associated with asthma. CAMKK2 and CISD1 were discovered to be ferroptosis-related hub genes in the black and magenta module, separately. We found that CAMKK2 and CISD1 were mainly involved in the CAMKK-AMPK signaling cascade, the adipocytokine signaling pathway, the metal cluster binding, iron-sulfur cluster binding, and 2 iron, 2 sulfur cluster binding in the enrichment analysis, which was strongly correlated with the development of ferroptosis. We found more infiltration of M2 macrophages and less Tregs infiltration in the asthma group compared to healthy controls. In addition, the expression levels of CISD1 and Tregs were negatively correlated. Through validation, we found that CAMKK2 and CISD1 expression were upregulated in the asthma group compared to the control group and would inhibit the occurrence of ferroptosis.Conclusion: CAMKK2 and CISD1 might inhibit ferroptosis and specifically regulate asthma. Moreover, CISD1 might be tied to the immunological microenvironment. Our results could be useful to provide potential immunotherapy targets and prognostic markers for asthma.
Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness
Authors: Silva-Gutiérrez Alexis , Artigas-Arias Macarena , Alegría-Molina Andrea , Guerra-Vega Pablo , Navarrete Pablo , Venegas Ángela , Montecinos Carlos , Vásquez Lorena , Moraga Karen , Rubilar César , Villagrán Germán , Parada Rodrigo , Vitzel Kaio Fernando , Marzuca-Nassr Gabriel Nasri 
Published: February 2023

Objective: Quantify and categorize by sex, age, and time spent on mechanical ventilation (MV), the decline in skeletal muscle mass, strength and mobility in critically ill patients infected with SARS-CoV-2 and requiring mechanical ventilation while at intensive care unit (ICU).Design: Prospective observational study including participants recruited between June 2020 and February 2021 at Hospital Clínico Herminda Martin (HCHM), Chillán, Chile. The thickness of the quadriceps muscle was evaluated by ultrasonography (US) at intensive care unit admission and awakening. Muscle strength and mobility were assessed, respectively, through the Medical Research Council Sum Score (MRC-SS) and the Functional Status Score for the Intensive Care Unit Scale (FSS-ICU) both at awakening and at ICU discharge. Results were categorized by sex (female or male), age (&lt;60 years old or ≥60 years old) and time spent on MV (≤10 days or &gt;10 days).Setting: Intensive care unit in a public hospital.Participants: 132 participants aged 18 years old or above (women n = 49, 60 ± 13 years; men n = 85, 59 ± 12 years) admitted to intensive care unit with a confirmed diagnosis of severe SARS-CoV-2 and requiring MV for more than 48 h were included in the study. Patients with previous physical and or cognitive disorders were excluded.Interventions: Not applicable.Results: Muscle thickness have significantly decreased during intensive care unit stay, vastus intermedius (−11%; p = 0.025), rectus femoris (−20%; p &lt; 0.001) and total quadriceps (−16%; p &lt; 0.001). Muscle strength and mobility were improved at intensive care unit discharge when compared with measurements at awakening in intensive care unit (time effect, p &lt; 0.001). Patients ≥60 years old or on MV for &gt;10 days presented greater muscle loss, alongside with lower muscle strength and mobility.Conclusion: Critically ill patients infected with SARS-CoV-2 and requiring MV presented decreased muscle mass, strength, and mobility during their intensive care unit stay. Factors associated with muscle mass, such as age &gt;60 years and &gt;10 days of MV, exacerbated the critical condition and impaired recovery.
Perceived meaning of life and satisfaction with life: A research synthesis using an online finding archive
Authors: Sameer Yomna , Eid Yasmine , Veenhoven Ruut 
Published: February 2023

Introduction“Meaning” and “happiness” are leading topics in positive psychology, but their relationship is not well understood. The first step to better understanding is to inspect the pattern of correlations found in the research literature. Specifically, we seek answers to the following questions of fact: (1) Is there a correlation between perceived meaning of life and satisfaction with life? (2) If so, is that correlation positive or negative? (3) How strong is this correlation? (4) How variable is this correlation across persons and situations? (5) Do the correlations differ across components of happiness? (6) What aspects of meaning are most/least associated with happiness? (7) What sources of meaning are most/least associated with happiness? (8) Does seeing meaning relate differently to happiness than searching for meaning?MethodWe took stock of the available research findings, using the World Database of Happiness, which holds standardized descriptions of 171 observed relations between perceived meaning of life and satisfaction with life.ResultsWe found strong correlations between happiness and the degree of perceived meaning in life but little correlation with the pursuit of meaning. While the correlation with the degree of meaning is positive at the micro-level of individuals, it appears to be negative at the macro-level of nations.DiscussionHaving established the above mentioned matters of fact, we considered the following questions on causality: (1) Is there an innate need for meaning? (2) How does the perceived meaning of life otherwise affect satisfaction with life? (3) How does satisfaction with life affect the perceived the meaning of life? (4) Why is the correlation positive at the micro-level of individuals, but negative at the macro-level of nations?ConclusionsWe conclude that there is no innate human need for meaning. Still, the perceived meaning of life can affect life satisfaction in various other ways, while life satisfaction will also affect the sense of meaning. Both positive and negative effects can be involved, the balance of which tends to be positive for seeing meaning but close to neutral for pursuing meaning.
Death anxiety, resilience, and family cohesion in parents of children and adolescents in the end stages of life
Authors: Mohammadi Fateme , Zahra Masoumi Seyedeh , Oshvandi Khodayar , Bijani Mostafa , Nikrouz Leila 
Published: February 2023

PurposeAdolescents in the end stages of life impose a lot of psychological stress on other family members, which may affect their resilience and quality of life. So, the aim of the present study was to investigate death anxiety, family adaptability and cohesion, and resilience in the parents of children and adolescents who were at the end stages of life.MethodsThis is a cross-sectional study. Two hundred and ten parents were selected by convenience sampling and completed the questionnaires such as demographics survey, the death anxiety scale, Connor-Davidson resilience scale, family adaptability, and cohesion scale. Data were analyzed by descriptive statistics (frequency, percentage, mean, and standard deviation), independent t-test, ANOVA, and multiple linear regressions. The significance level was set at p &lt; 0.05.ResultThe findings showed that death anxiety in parents of children and adolescents in the end stages of life has a significant inverse correlation with family adaptability and cohesion (p &lt; 0.001, r = −0.92) and resilience (p &lt; 0.001, r = −0.90). The variables of family adaptability and cohesion, resilience, number of children, the children’s illness duration, and marital status can predict 61.34% of the death anxiety variance in these parents.ConclusionThe parents of children and adolescents in end stages of life reported high death anxiety and moderate family adaptability and cohesion, but low resilience. Accordingly, pediatric nurses and healthcare policymakers should develop comprehensive support plans for these parents to facilitate their adaptation and increase their family adaptability and cohesion.
Experiences of seeking and accessing medical care among persons with major depression: A qualitative descriptive study of persons with depression in China
Authors: Zhou Yan Hua , Leung Doris , Lin Jian Kui , Hu Li Chan , Lin Xiao Yang , Zhang Xuelin , Mak Yim Wah 
Published: February 2023

IntroductionA large number of people in China are affected by depression, yet tend to delay seeking treatment. This study aims to explore persons living with depression and their journey of diagnoses and seeking professional medical help in China.MethodsSemi-structured interviews were conducted with 20 persons who visiting physicians to be diagnosed and receive professional help from a large mental health center in Guangzhou, Guangdong province, China. Individual interviews were conducted and data were analyzed using content analysis.ResultsThree themes were identified from the findings: (1) “noticed something was wrong”; (2) negotiated decisions with their own narratives and the personal suggestions of others; and (3) gave new meaning to their experiences of depression, whereby they sought medical treatment.DiscussionThe findings of the study indicated that the impact of progressive depressive symptoms on the participants’ daily lives was a strong motivation for them to seek professional help. The obligation to care for and support their family prevented them from initially disclosing their depressive symptoms to family members, but eventually prompted them to seek professional help and persist in follow-up treatment. Some participants experienced unexpected benefits (e.g., relief at no longer feeling “alone”) during their first visit to the hospital for depression or when they were diagnosed with depression. The results suggest a need to continue to actively screen for depression and provide more public education to prevent negative assumptions and reduce public and personal stigmatization of those with mental health problems.
Biological interpretation of the sporadic sputum smear-positive-culture-negative outcome for patients with tuberculosis undertaking treatments
Authors: Luo Jingjing , Yu Xia , Dong Lingling , Huo Fengmin , Ma Yifeng , Liang Qian , Shang Yuanyuan , Huang Hairong 
Published: February 2023

IntroductionThe objective of the study was to identify the causes of smear-positive-culture-negative (S+/C–) outcomes of patients with tuberculosis during the treatment course.MethodsA laboratory-based retrospective study was performed at the Beijing Chest Hospital in China. Within the study period, all patients with pulmonary tuberculosis (PTB) who undertook anti-TB treatments and yielded smear positive outcomes with simultaneous culture outcomes on sputa were considered. Patients were classified into three groups: (I) performed LJ medium culture only; (II) performed BACTEC MGIT960 liquid culture only; and (III) performed both LJ culture and MGIT960 culture. The S+/C– rates of each group were analyzed. The clinical medical records regarding patient category, follow-up bacteriologic examination data, and treatment response were investigated.ResultsIn total, 1,200 eligible patients were enrolled, and the overall S+/C– rate was 17.5% (210/1,200). Group I had obviously higher S+/C– rate (37%) than group II (18.5%) and group III (9.5%). When solid and liquid cultures were considered independently, the S+/C– outcome was observed more frequently in the solid culture group than in the liquid culture group (30.4%, 345/1,135 vs. 11.5%, 100/873; p &lt; 0.001, χ2 = 102.64). Among the 102 S+/C– patients who had follow-up cultures performed, 35 (34.3%) had positive culture outcomes. Whereas among the 67 patients with follow-up information for more than 3 months but without supportive bacteriological evidence, 45 (67.2%, 45/67) had unfavorable prognosis (including relapse and unimproved conditions), and only 22 (32.8%, 22/67) patients had improved conditions. Compared with new cases, retreated cases produced S+/C– outcomes more frequently and had more chances to be cultivated bacilli successfully afterward.ConclusionsAmong our patients, the sporadic smear positive and culture negative outcomes for sputa are more likely associated with the technical failures of culture than with dead bacilli, and this is especially noteworthy for LJ medium culture.
Multidimensional poverty of persons with disabilities in China: An analysis of poverty reduction effect of employment services
Authors: Wang Xiaofeng , Guo Jiamin , Li Hu 
Published: February 2023

IntroductionDisability is a global public health problem, and poverty due to illness and disability has always been a major problem and challenge for global poverty governance. In order to eradicate poverty, China has carried out a series of welfare reforms and employment interventions for people with disabilities. The purpose of this study is to examine the levels of multidimensional poverty of persons with disabilities aged 16–59 in China and the poverty reduction effect of employment services.MethodsThe Alkire-Foster (AF) method is applied to measure and decompose the multidimensional poverty index (MPI) of people with disabilities in this study. In order to make the results more robust, ordinary least squares (OLS) regression and the combination of propensity score matching and difference-in-differences (PSM-DID) are used to study the effect of employment services on multidimensional poverty of the disabled.ResultsThe results show that among persons with disabilities aged 16–59, about 90% are deprived in at least one dimension, and about 30% are in a state of severe multidimensional poverty until 2019. The contributions of deprivation in the dimensions of education and social participation are remarkably higher than dimensions of economy, health and insurance. In addition, employment services have a significant improvement effect on multidimensional poverty, which is reflected not only in the economic dimension, but also in the dimensions of education, insurance and social participation.ConclusionPeople with disabilities are generally in multidimensional poverty in China, and their abilities in learning and social integration are seriously inadequate. Employment services have played a great role in improving poverty, but the improvement has been different in different dimensions and different disability categories. These findings provide important evidence for recognizing multidimensional poverty of persons with disabilities and the poverty reduction effect of employment services, which will help to formulate more reasonable public policies to eradicate poverty.
Forest degradation modifies litter production, quality, and decomposition dynamics in Southern temperate forests
Authors: Leal Fabiola , Aburto Felipe , Aguilera Natalia , Echeverría Cristian , Gatica-Saavedra Paula 
Published: February 2023

IntroductionAnthropic disturbances are driving unprecedented changes in forest ecosystem functions and biogeochemical processes, hindering the forests’ benefits to society. Litter decomposition is one of the most critical processes that regulate forests’ carbon and nutrient cycling. However, how forest degradation affects litter decomposition and elemental dynamics requires further examination. The main objective of this study was to evaluate the effect of forest degradation on the production and decomposition of litter and C,N, and P dynamics in a temperate forest in south-central Chile.MethodsLitter traps and litter bags were installed in three Long Term Research Forest Plots (LTER) representing different conservation states: mature, secondary, and degraded Nothofagus forests.Results and DiscussionThe total litter input varied between 3.5 to 1.1 Mg ha–1 year–1 in the mature and degraded forests, respectively. We found the highest lignin and nutrient levels in the degraded forest and the lowest in the mature forest. In the mature forest, 44% of the initial litter was decomposed, while in the degraded forest it only reached 7%. Decomposing litter showed the lowest C:N and C:P ratios in the mature forest most of the year. The balance between inputs and outputs yielded a more substantial litter accumulation in the mature forests.ConclusionOur results strongly suggest that anthropogenic degradation altered litter quality and nutrient dynamics while decreasing litter production and decomposition.