bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced resolution and sensitivity acoustic-resolution photoacoustic microscopy with semi/unsupervised GANs
Authors: Le Thanh Dat , Min Jung-Joon , Lee Changho 
Published: August 2023

AbstractAcoustic-resolution photoacoustic microscopy (AR-PAM) enables visualization of biological tissues at depths of several millimeters with superior optical absorption contrast. However, the lateral resolution and sensitivity of AR-PAM are generally lower than those of optical-resolution PAM (OR-PAM) owing to the intrinsic physical acoustic focusing mechanism. Here, we demonstrate a computational strategy with two generative adversarial networks (GANs) to perform semi/unsupervised reconstruction with high resolution and sensitivity in AR-PAM by maintaining its imaging capability at enhanced depths. The b-scan PAM images were prepared as paired (for semi-supervised conditional GAN) and unpaired (for unsupervised CycleGAN) groups for label-free reconstructed AR-PAM b-scan image generation and training. The semi/unsupervised GANs successfully improved resolution and sensitivity in a phantom and in vivo mouse ear test with ground truth. We also confirmed that GANs could enhance resolution and sensitivity of deep tissues without the ground truth.
Effects of preoperative sarcopenia-related parameters on the musculoskeletal and metabolic outcomes after bariatric surgery: a one-year longitudinal study in females
Authors: Crispim Carvalho Nara Nóbrega , Martins Vinícius José Baccin , Filho João Modesto , de Arruda Neta Adélia da Costa Pereira , Pimenta Flávia Cristina Fernandes , de Brito Alves José Luiz 
Published: August 2023

AbstractReduced muscle mass and/or strength are risk factors for metabolic and musculoskeletal impairment. The present study evaluated anthropometric, metabolic, and musculoskeletal outcomes in females with and without sarcopenic-obesity parameters who underwent bariatric surgery during a 1-year follow-up. A prospective, single-center cohort study was conducted in females with obesity undergoing preoperative evaluation for surgery. In the preoperative period, females were allocated into obesity with sarcopenic-obesity parameters (SOP group, n = 15) and without sarcopenic-obesity parameters (obesity group, n = 21). Sarcopenic obesity parameters were defined as lower appendicular skeletal mass adjusted for weight (ASM/wt) and/or low handgrip strength (HGS). Anthropometric, metabolic, and musculoskeletal parameters were assessed before surgery and at 3 months, 6 months, and a 1-year after bariatric surgery. Weight loss was similar between groups (p > 0.05). Weight, body mass index, fat mass, body fat percentage, skeletal muscle mass, fat-free mass, fat-free mass index, HGS were reduced in both groups during the 1-year follow-up (p < 0.05). However, when muscle mass and strength were analyzed relative to body size, an improvement after bariatric surgery was found in both groups (p < 0.05). Total cholesterol, LDL-c, triglycerides, fasting glucose, glycated hemoglobin, insulin, and insulin resistance were reduced in both groups during the 1-year follow-up (p < 0.05). In addition, HDL-c serum concentration increased in females with and without sarcopenic-obesity parameters over the 1-year follow-up (p < 0.05). Both groups had decreased bone mineral density (BMD) at all sites (lumbar spine, femoral neck, and total femur) over the 1-year follow-up (p < 0.05). The highest quartile of ASM/wt was positively associated with BMD variables in a longitudinal analysis, suggesting that preserved ASM/wt in pre-surgery may be beneficial for BMD after 1 year of bariatric surgery. The results showed that bariatric surgery promotes similar musculoskeletal and metabolic changes in females with preserved muscle mass and strength or in females with sarcopenia-related parameters.
Photocatalytically reactive surfaces for simultaneous water harvesting and treatment
Authors: Ghosh Ritwick , Baut Adrien , Belleri Giorgio , Kappl Michael , Butt Hans-Jürgen , Schutzius Thomas M. 
Published: August 2023

AbstractAtmospheric water harvesting provides decentralized and sustainable supplies of fresh water in areas away from natural water resources. However, an important challenge is that water sources such as fog are subject to contamination from airborne pollutants, especially near population centres. Here we demonstrate a rationally designed system that can capture fog at high efficiency while simultaneously degrading organic pollutants. At the heart of our design is a wire mesh coated with anatase titanium dioxide nanoparticles embedded in a polymer matrix. Once activated by sunlight, the photoactive titanium dioxide layer decomposes organic molecules such as diesel, even in the absence of sunlight; moreover, the wettability of the mesh surface is engineered to enhance water extraction. In outdoor tests, the device can maintain a good fog harvesting performance as well as a water treatment efficiency of >85%. The continuous production of water with passive purification demonstrated in our study provides an energy-free solution to address water scarcity.
Measuring Articulatory Patterns in Amyotrophic Lateral Sclerosis Using a Data-Driven Articulatory Consonant Distinctiveness Space Approach
Authors: Teplansky Kristin J. , Wisler Alan , Green Jordan R. , Heitzman Daragh , Austin Sara , Wang Jun 
Published: August 2023

Purpose:
The aim of this study was to leverage data-driven approaches, including a novel articulatory consonant distinctiveness space (ACDS) approach, to better understand speech motor control in amyotrophic lateral sclerosis (ALS).

Method:

Electromagnetic articulography was used to record tongue and lip movement data during the production of 10 consonants from healthy controls (
n
= 15) and individuals with ALS (
n
= 47). To assess phoneme distinctness, speech data were analyzed using two classification algorithms, Procrustes matching (PM) and support vector machine (SVM), and the area/volume of the ACDS. Pearson's correlation coefficient was used to examine the relationship between bulbar impairment and the ACDS. Analysis of variance was used to examine the effects of bulbar impairment on consonant distinctiveness and consonant classification accuracies in clinical subgroups.

Results:

There was a significant relationship between the ACDS and intelligible speaking rate (area,
p
= .003; volume,
p
= .010), and the Amyotrophic Lateral Sclerosis Functional Rating Scale–Revised (ALSFRS-R) bulbar subscore (area,
p
= .009; volume,
p
= .027). Consonant classification performance followed a consistent pattern with bulbar severity, where consonants produced by speakers with more severe ALS were classified less accurately (SVM = 75.27%; PM = 74.54%) than the healthy, asymptomatic, and mild–moderate groups. In severe ALS, area of the ACDS was significantly condensed compared to both asymptomatic (
p
= .004) and mild–moderate (
p
= .013) groups. There was no statistically significant difference in area between the severe ALS group and healthy speakers (
p
= .292).

Conclusions:
Our comprehensive approach is sensitive to early oromotor changes in response due to disease progression. The preserved articulatory consonant space may capture the use of compensatory adaptations to counteract influences of neurodegeneration.

Supplemental Material:

https://doi.org/10.23641/asha.22044320
Large Interferometer For Exoplanets (LIFE)
Authors: Matsuo Taro , Dannert Felix , Laugier Romain , Quanz Sascha P. , Kovačević Andjelka B. ,   LIFE Collaboration
Published: August 2023

Context.A mid-infrared nulling-space interferometer offers a promising way to characterize thermal light from habitable planet candidates around Sun-like stars. However, one of the main challenges inherent in achieving this ambitious goal is the high-precision stability of the optical path difference and amplitude over a few days for planet detections and all the way up to a few weeks for in-depth characterization. This is related to mission parameters such as aperture size, number of apertures, and total instrument throughput.Aims.Here, we propose a new method called phase-space synthesis decomposition (PSSD) to shorten the stability requirement to a scale of minutes, significantly relaxing the technological challenges of the mission.Methods.By focusing on the consideration of what exactly modulates the planetary signal in the presence of the stellar leak and systematic error, PSSD prioritizes the modulation of the signals along the wavelength domain rather than baseline rotation. Modulation along the wavelength domain allows us to extract source positions in parallel to the baseline vector for each exposure. The sum of the one-dimensional data is converted into two-dimensional information. Based on the reconstructed image, we constructed a continuous equation and extract the spectra through the singular value decomposition, while efficiently separating them from a long-term systematic stellar leak.Results.We performed numerical simulations to investigate the feasibility of PSSD for the Large Interferometer For Exoplanets (LIFE) mission concept. We confirm that multiple terrestrial planets in the habitable zone around a Sun-like star at 10 pc can be detected and characterized despite high levels and long durations of systematic noise. We also find that PSSD is more robust against a sparse sampling of the array rotation compared to purely rotation-based signal extraction. Using PSSD as signal extraction method significantly relaxes the technical requirements on the signal stability and further increases the feasibility of the LIFE mission.
Facteurs prédicteurs de la mortalité périnatale suite à l’asphyxie & environnement de naissance : étude cas-témoins
Authors: Yakini Souad , Amane Mounia , Bou-Iselmane Maryama , Elghazouani Hanane , Iziki Hayat , Elqadiri Ichraq , Boutasoumaat Kaoutar , Bouaiti Elarbi , Barkat Amina 
Published: August 2023

L’asphyxie périnatale (AP) est une cause importante de mortalité et de morbidité lourdes, et/ ou à long terme; Chaque année dans le monde, l’OMS estime que l’AP entraine environ 4 millions des décès néonataux et un million d’enfants sévèrement handicapés;
La présente recherche a ciblé de bien déterminer les facteurs prédicteurs de la mortalité périnatale suite à l’asphyxie périnatale. C’est une étude cas témoins non apparié menée au niveau de la maternité du centre hospitalier universitaire Mohamed VI de Marrakech. Au cours de la période allant du 1avril 2022 au 30 juin 2022, 157 nouveau-nés atteints d’AP ont été inclus dans l’étude avec 31 cas et 126 témoins. Un cahier d’observation renfermant les données sociodémographiques, cliniques et biologiques des nouveau-nés a bien servit de base pour la collecte des données nécessaires.
Relativement aux résultats obtenus, plusieurs facteurs prédicteurs ont été associés significativement à la mortalité périnatale : les antécédents maternels [ (ORA =31,876, 95%, CI : (1,346; 755,149)]; le retard de croissance intra-utérin [(ORA= 4711,799), 95%, IC : ( 48,964, 453416,766)]; le score d’Apgar après 5 min : inferieur ou égale à 3 : [(ORA=139,75), 95%, CI : (16,523; 1182,01)], et les malformations congénitales : [(ORA=241,435), 95%, CI : (6,044; 9644,748)].
Plusieurs suggestions émergent, l’identification précoce des nouveau-nés à haut risque d’AP, et la mise en place des mesures efficaces de prévention, de diagnostic et de la prise en charge, sont tous des mesures cruciales afin d’éviter les complications délétères de l’AP dont la plus redoutable est la mortalité périnatale.
Altered Gene Expression of Cytochrome P450 and ABC Transporter in Human Hepatocellular Carcinoma HepG2 Cells Exposed to Bardoxolone Methyl
Authors: Nagai Katsuhito , Fukuno Shuhei , Miura Takeshi , Yasuda-Imanishi Eri , Konishi Hiroki 
Published: August 2023

AbstractBardoxolone methyl (BX) is expected to be an innovate therapeutic agent for chronic kidney disease (CKD). The aim of the present study was to examine whether the expression of subtypes of cytochrome P450 (CYP) and ABC transporters was altered in human hepatocellular carcinoma HepG2 cells by exposure to BX. The expression of mRNAs for CYP1A2, CYP2E1, P-glycoprotein, multidrug resistance-associated protein 1–3, and breast cancer resistance protein was significantly increased by exposure of HepG2 cells to BX, while the expression of CYP3A4 mRNA was significantly decreased under the same conditions. BX had no significant effect on the expression of mRNAs for CYP2C9 and CYP2C19 in HepG2 cells. In conclusion, this study demonstrated that the gene expression of several CYPs and ABC transporters in HepG2 cells was altered when exposed to BX, suggesting the need to pay careful attention to drug-drug interactions in patients receiving BX for CKD treatment.
Die Bedeutung von Kumpantieren für Opioidabhängige in Substitutionstherapie
Authors: Schulze Michael Christian 
Published: August 2023

ZusammenfassungZiel Viele Opioidabhängige haben Kumpantiere. In der Studie wird untersucht, welche Rolle sie in ihrem Leben spielen und welchen Einfluss sie auf die Suchterkrankung ausüben. Der Begriff Kumpantier unterstreicht, dass zwischen Mensch und Tier eine enge Beziehung besteht.Methodik Alle substituierten Opioidabhängigen aus zwei suchtmedizinischen Praxen in Berlin wurden befragt, ob sie Tiere besitzen. Mit 12 tierhaltenden Abhängigen wurden leitfadengestützte Interviews geführt, ergänzt durch einen Kurzfragebogen. Die Auswertung erfolgte mit der qualitativen Inhaltsanalyse.Ergebnisse 27 von 104 substituierten Opioidabhängigen (26%) besitzen Tiere, v. a. Katzen und Hunde. Für die 12 Befragten spielen die Tiere eine entscheidende Rolle in ihrem Leben. Sie weisen ihnen eine Aufgabe und Verantwortung zu, strukturieren ihren Tag, unterstützen sie emotional und lenken sie von negativen Gedanken und Gefühlen ab. Sie scheinen auch die Rückfallgefahr sowie den Suchtdruck zu mindern. Gegenüber den positiven Wirkungen der Tiere treten die negativen in den Hintergrund.Schlußfolgerungen Auf Grund ihrer hohen Bedeutung für die Abhängigen sollten Kumpantiere in die Überlegungen und Strategien der Behandlungsteams einbezogen werden und mehr Einrichtungen der Gesundheits- und Suchthilfe einen Zugang mit Tieren ermöglichen.
GC-MS analysis and in silico docking of constituents of Cinnamomum
malabatrum against CYP450 17α and CYP450 19 (Aromatase)- Key targets for
hyperandrogenism
Authors: Soumya V. , Deepa S. , Thachil Knolin.K. , Saravanan J. , Hariprasad R. 
Published: August 2023

AbstractPoly cystic ovary syndrome (PCOS) is considered as one of the common hormonal
disorders affecting 6–20% of women in their reproductive age
with characteristic features include anovulatory infertility, hyperandrogenism,
cystic follicles and insulin resistance. The gene CYP play an important role in
pathophysiology of hyperandrogenism associated with PCOS. An elevated androgens
are reported in PCOS condition due to overexpression of the enzyme
CYP450 17 α. As well as diminished levels of
aromatase (CYP450 19) were observed in several hyperandrogenic PCOS
patients. The powdered leafy material of Cinnamomum malabatrum was
subjected to Soxhlet extraction. The plant extract was subjected to Gas
chromatography-MS analysis (GC-MS), and the chromatogram obtained revealed the
presence of active chemical constituents like 1(10),9(11)-B-Homolanistadiene for
the first time and other potential compounds. Hypothesis has raised to interpret
the efficiency of phytoconstituents of Cinnamomum malabatrum on these
enzyme targets and which may be a novel drug candidate for the treatment and
maintenance of hyperandrogenism associated with PCOS. Thus, the results obtained
from the in-silico study of Cinnamomum malabatrum leaf extract
using computational approaches indicate that the phytoconstituents have good
affinities for the selected two key targets. ADME and PASS studies has been
performed for active phytoconstituents homolanistadiene, β-sitosterol,
cycloartenol and a pyrazole derivative, and results revealed the Lipinski
drug-likeness and pharmacological potential. In conclusion, this work throws a
new insight into the possibility of the active phytoconstituents on binding the
two active CYP45017 α and CYP45019 aromatase
enzymes which facilitates development of novel compounds for hyperandrogenism
associated with PCOS.
A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications
Authors: Alheety Mustafa A. , Mohammed Leqaa A. , Farhan Mohammed Alwan , Dadoosh Safaa A. , Majeed Abdulwahhab H. , Mahmood Ali Saadon , Mahmoud Zaid H. 
Published: August 2023

AbstractBenzimidazole is a heterocyclic compound that contains two nitrogen atoms and is formed by fusing a benzene ring with an imidazole. Benzimidazole and its derivatives are prepared in a range of ways, including condensation of o-phenylenediamine with carbonyl compounds (aldehydes and ketones) or with carboxylic acids and their derivatives. Benzimidazoles can also be prepared by rearranging other heterocyclic compounds such as quinoxaline derivatives and triazole derivatives. In recent decades, benzimidazoles have been prepared using green methods such as microwaves and ultrasound, the use of environmentally friendly catalysts, and by using photochemical reactions. Benzimidazoles have attracted the interest of scientists and researchers due to the great medical efficacy exhibited by such derivatives against various diseases. The benzimidazole derivatives show many pharmacological activities such as anticancer, anti-inflammatory, antioxidant, anticoagulant, and antiviral action. This review focuses on benzimidazole and its derivatives, the most important methods used for its preparation, as well as the biological applications of the compound in our daily lives.1 Introduction2 Imidazole and Benzimidazole3 Methods of Synthesis of Benzimidazole Derivatives3.1 Condensation of 2-Aminoaniline (o-Phenylenediamine)3.2 Via Rearrangement3.3 Green Synthesis of Benzimidazole4 Biological Activity of Benzimidazole Derivatives4.1 Anticancer Activity4.2 Anti-inflammatory Activity4.3 Antioxidant Activity4.4 Anticonvulsants Activity4.5 Anticoagulants Activity4.6 Antimicrobial Activity4.7 Other Biological Applications5 Conclusion
Comparative diagnostic yield of different endoscopic techniques for tissue sampling of upper gastrointestinal subepithelial lesions: a network meta-analysis
Authors: Facciorusso Antonio , Crinò Stefano Francesco , Fugazza Alessandro , Carrara Silvia , Spadaccini Marco , Colombo Matteo , Ramai Daryl , Mangiavillano Benedetto , Chandan Saurabh , Gkolfakis Paraskevas , Mohan Babu , Hassan Cesare , Repici Alessandro 
Published: August 2023

Abstract
Background There is limited evidence on the comparative diagnostic performance of endoscopic tissue sampling techniques for subepithelial lesions. We performed a systematic review with network meta-analysis to compare these techniques.
Methods A systematic literature review was conducted for randomized controlled trials (RCTs) comparing the sample adequacy and diagnostic accuracy of bite-on-bite biopsy, mucosal incision-assisted biopsy (MIAB), endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), and EUS-guided fine-needle biopsy (FNB). Results were expressed as relative risk (RR) and 95%CI.
Results Eight RCTs were identified. EUS-FNB was significantly superior to EUS-FNA in terms of sample adequacy (RR 1.20 [95%CI 1.05–1.45]), whereas none of the other techniques significantly outperformed EUS-FNA. Additionally, bite-on-bite biopsy was significantly inferior to EUS-FNB (RR 0.55 [95%CI 0.33–0.98]). Overall, EUS-FNB appeared to be the best technique (surface under cumulative ranking [SUCRA] score 0.90) followed by MIAB (SUCRA 0.83), whereas bite-on-bite biopsy showed the poorest performance. When considering lesions <20 mm, MIAB, but not EUS-FNB, showed significantly higher accuracy rates compared with EUS-FNA (RR 1.68 [95%CI 1.02–2.88]). Overall, MIAB ranked as the best intervention for lesions <20 mm (SUCRA score 0.86 for adequacy and 0.91 for accuracy), with EUS-FNB only slightly superior to EUS-FNA. When rapid on-site cytological evaluation (ROSE) was available, no difference between EUS-FNB, EUS-FNA, and MIAB was observed.
Conclusion EUS-FNB and MIAB appeared to provide better performance, whereas bite-on-bite sampling was significantly inferior to the other techniques. MIAB seemed to be the best option for smaller lesions, whereas EUS-FNA remained competitive when ROSE was available.
Serological Screening for Celiac Disease and Gastrointestinal
Absorption Disorders in Patients with Autoimmune Endocrine
Diseases
Authors: Akkurt Kocaeli Aysen , Cander Soner , Gül Özen Öz , Sisman Pınar , Ersoy Canan , Erturk Erdınc 
Published: August 2023

AbstractCeliac disease (CD) accompanying autoimmune endocrine diseases (AED) is generally
asymptomatic. This study aimed to evaluate the frequency of clinically overt or
silent CD in patients diagnosed with autoimmune endocrinopathy and the clinical
effects of silent CD in these endocrinopathies. The study included 166 patients
with known or newly diagnosed mono-/polyglandular AED and 90 age- and
gender-matched healthy controls. The patients were classified into four groups:
type 1 diabetes mellitus (DM) (n=44), Hashimoto’s thyroiditis
(HT) (n=68), Addison’s disease (AD) (n=17), and
autoimmune polyglandular syndrome (APS) (n=37). All subjects were
serologically screened for tissue transglutaminase antibody (tTG) IgA and IgG.
In addition, to evaluate the possible systemic consequences of CD, serum
parathormone (PTH), 25-hydroxicholecalsiferol (25-OH-Vit D), vitamin B12, folic
acid, iron, iron-binding capacity (IBC), and ferritin levels were measured. In
the total series, 193 (75.4%) individuals were females, and 63
(24.6%) were males. TTG IgA antibody positivity was found in 23 among
166 patients, while no positivity was encountered in the healthy control group.
The highest rates of positive tTg IgA frequency were detected in AD, with
29.4% (5/17). Serum 25-OH-Vit D, vitamin B12, folic acid, iron,
and ferritin levels were significantly lower in AEDs compared to controls
(p<0.001), and the lowest these parameters were detected in patients
with AD. The serologic CD prevalence is higher in autoimmune mono-/and
polyglandular endocrine diseases than in the control group. The data support
recommends regular screening for CD in all patients with AEDs.
Functionalized Aza-BODIPYs and Their Use in the Synthesis of Aza-BODIPY-Based Complex Systems
Authors: Ravikanth Mangalampalli , Yadav Bharti 
Published: August 2023

AbstractIn this account, we present syntheses of various functionalized aza-boron-dipyrromethene dyes (aza-BODIPYs) in which the functional groups are directly introduced at the 2- or 6-positions of the aza-BODIPYs or on aryl rings present at the 1-, 3-, 5-, and 7-positions of the aza-BODIPYs. Some of these functionalized aza-BODIPYs have been used for the synthesis of aza-BODIPY-based energy-transfer cassettes and light-harvesting complexes.1	Introduction2	Monofunctionalized Aza-BODIPYs2.1	2-/6-Monofunctionalized Aza-BODIPYs2.2	1-/3-/5-/7-Monofunctionalized Aza-BODIPYs3	Difunctionalized Aza-BODIPYs.3.1	2,6-Difunctionalized Aza-BODIPYs3.2	3,5-Difunctionalized Aza-BODIPYs3.3	1,7-Difunctionalized Aza-BODIPYs4	Miscellaneous5	Conclusion