bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Insights of ANGPTL-3 on Modulating Cholesterol Efflux
Capacity Induced by HDL Particle
Authors: Lai Min , Jiang Xiang , Wang Bin , Cheng Ye , Su Xin 
Published: April 2023

Background:
Angiopoietin-like protein 3 (ANGPTL-3) modulates lipid
metabolism and the risk of coronary artery disease (CAD), especially stable angina (SA),
via suppressing lipoprotein lipase (LPL). However, whether there are other mechanisms
is not elucidated yet. The current research explored the modulatory roles of ANGPTL-3
on high-density lipoprotein (HDL), which further affects atherosclerotic development

Methods:
A total of 200 individuals were enrolled in the present study. Serum ANGPTL-
3 levels were detected via enzyme-linked immunosorbent assays (ELISA). Cholesterol
efflux capacity induced by HDL particles was detected through H3-cholesterol loading
THP-1 cell.

Results:
The serum ANGPTL-3 levels presented no significant discordance between the
SA group and the non-SA group, whereas the serum ANGPTL-3 levels in type 2
diabetes mellitus (T2DM) group were significantly elevated compared with those in the
non-T2DM group [428.3 (306.2 to 736.8) ng/ml vs. 298.2 (156.8 to 555.6) ng/ml, p
<0.05]. Additionally, the serum ANGPTL-3 levels were elevated in patients with low TG
levels compared to those in patients with high TG levels [519.9 (377.6 to 809.0) ng/ml
vs. 438.7 (329.2 to 681.0) ng/ml, p <0.05]. By comparison, the individuals in the SA
group and T2DM group presented decreased cholesterol efflux induced by HDL particles
[SA: (12.21±2.11)% vs. (15.51±2.76)%, p <0.05; T2DM: (11.24±2.13)% vs. (14.65±
3.27)%, p <0.05]. In addition, the serum concentrations of ANGPTL-3 were inversely
associated with the cholesterol efflux capacity of HDL particles (r=-0.184, p <0.05).
Through regression analysis, the serum concentrations of ANGPTL-3 were found to be
an independent modulator of the cholesterol efflux capacity of HDL particles
(standardized β=-0.172, p <0.05).

Conclusion:
ANGPTL-3 exhibited a negative modulatory function on cholesterol efflux
capacity induced by HDL particles.
Delivering a Home-Based Exercise Program to Youth With Osteogenesis Imperfecta: Protocol for a Comparative-Approach Study
Authors: Powell Georgia , Gagnon Marianne , Komarova Svetlana , Rauch Frank , Veilleux Louis-Nicolas 
Published: April 2023

Background
Osteogenesis imperfecta (OI) is a rare bone fragility disorder associated with muscle weakness. Individuals with OI may therefore benefit from exercise interventions aiming to improve muscle and bone strength. Given the rarity of OI, many patients do not have access to exercise specialists who are familiar with the disorder. As such, telemedicine, the provision of health care through technology to provide care at a distance, may be well suited for this population.

Objective
The main objectives are (1) to investigate the feasibility and cost-effectiveness of 2 telemedicine approaches for the delivery of an exercise intervention for youth with OI and (2) to assess the impact of the exercise intervention on muscle function and cardiopulmonary fitness in youth with OI.

Methods
Patients with OI type I (the mildest form of OI; n=12, aged 12-16 years) from a pediatric orthopedic tertiary hospital will be randomized to receive a 12-week remote exercise intervention in either (1) a supervised group (n=6), monitored every session, or (2) a follow-up group (n=6), receiving monthly progress update appointments. Participants will undergo the following pre- and postintervention evaluations: sit-to-stand test, push-up test, sit-up test, single-legged balance test, and a heel-rise test. Both groups will be given the same 12-week exercise regimen, which includes cardiovascular, resistance, and flexibility training. For each exercise training session involving the supervised group, a kinesiologist will provide instructions to participants through live video sessions using a teleconferencing application. On the other hand, the follow-up group will discuss their progress with the kinesiologist every 4 weeks over a teleconferencing video call. Feasibility will be assessed by recruitment, adherence, and completion rates. A cost-effectiveness analysis of both approaches will be computed. Changes in muscle function and cardiopulmonary fitness will be examined between the 2 groups, pre- and postintervention.

Results
It is anticipated that the supervised group will have higher adherence and completion rates compared to the follow-up group, which may be associated with greater physiological benefits; however, it may not be as cost-effective compared to the follow-up approach.

Conclusions
By determining the most feasible telemedicine approach, this study may serve as a basis for providing increased access to specialized adjunct therapies for individuals with rare disorders.

International Registered Report Identifier (IRRID)
PRR1-10.2196/40262
Optometrists' Perspectives Regarding Artificial Intelligence Aids and Contributing Retinal Images to a Repository: Web-Based Interview Study
Authors: Constantin Aurora , Atkinson Malcolm , Bernabeu Miguel Oscar , Buckmaster Fiona , Dhillon Baljean , McTrusty Alice , Strang Niall , Williams Robin 
Published: April 2023

Background
A repository of retinal images for research is being established in Scotland. It will permit researchers to validate, tune, and refine artificial intelligence (AI) decision-support algorithms to accelerate safe deployment in Scottish optometry and beyond. Research demonstrates the potential of AI systems in optometry and ophthalmology, though they are not yet widely adopted.

Objective
In this study, 18 optometrists were interviewed to (1) identify their expectations and concerns about the national image research repository and their use of AI decision support and (2) gather their suggestions for improving eye health care. The goal was to clarify attitudes among optometrists delivering primary eye care with respect to contributing their patients’ images and to using AI assistance. These attitudes are less well studied in primary care contexts. Five ophthalmologists were interviewed to discover their interactions with optometrists.

Methods
Between March and August 2021, 23 semistructured interviews were conducted online lasting for 30-60 minutes. Transcribed and pseudonymized recordings were analyzed using thematic analysis.

Results
All optometrists supported contributing retinal images to form an extensive and long-running research repository. Our main findings are summarized as follows. Optometrists were willing to share images of their patients’ eyes but expressed concern about technical difficulties, lack of standardization, and the effort involved. Those interviewed thought that sharing digital images would improve collaboration between optometrists and ophthalmologists, for example, during referral to secondary health care. Optometrists welcomed an expanded primary care role in diagnosis and management of diseases by exploiting new technologies and anticipated significant health benefits. Optometrists welcomed AI assistance but insisted that it should not reduce their role and responsibilities.

Conclusions
Our investigation focusing on optometrists is novel because most similar studies on AI assistance were performed in hospital settings. Our findings are consistent with those of studies with professionals in ophthalmology and other medical disciplines: showing near universal willingness to use AI to improve health care, alongside concerns over training, costs, responsibilities, skill retention, data sharing, and disruptions to professional practices. Our study on optometrists’ willingness to contribute images to a research repository introduces a new aspect; they hope that a digital image sharing infrastructure will facilitate service integration.
Motivational Message Framing Effects on Physical Activity Dynamics in a Digital Messaging Intervention: Secondary Analysis
Authors: Lee Alexandra M , Hojjatinia Sahar , Courtney Jimikaye B , Brunke-Reese Deborah , Hojjatinia Sarah , Lagoa Constantino M , Conroy David E 
Published: April 2023

Background
Digital smartphone messaging can be used to promote physical activity to large populations with limited cost. It is not clear which psychological constructs should be targeted by digital messages to promote physical activity. This gap presents a challenge for developing optimal content for digital messaging interventions.

Objective
The aim of this study is to compare affectively framed and social cognitively framed messages on subsequent changes in physical activity using dynamical modeling techniques.

Methods
We conducted a secondary analysis of data collected from a digital messaging intervention in insufficiently active young adults (18-29 years) recruited between April 2019 and July 2020 who wore a Fitbit smartwatch for 6 months. Participants received 0 to 6 messages at random per day across the intervention period. Messages were drawn from 3 content libraries: affectively framed, social cognitively framed, or inspirational quotes. Person-specific dynamical models were identified, and model features of impulse response and cumulative step response were extracted for comparison. Two-way repeated-measures ANOVAs evaluated the main effects and interaction of message type and day type on model features. This early-phase work with novel dynamic features may have been underpowered to detect differences between message types so results were interpreted descriptively.

Results
Messages (n=20,689) were paired with valid physical activity monitoring data from 45 participants for analysis. Received messages were distributed as 40% affective (8299/20,689 messages), 39% social-cognitive (8187/20,689 messages), and 20% inspirational quotes (4219/20,689 messages). There were no statistically significant main effects for message type when evaluating the steady state of step responses. Participants demonstrated heterogeneity in intervention response: some had their strongest responses to affectively framed messages, some had their strongest responses to social cognitively framed messages, and some had their strongest responses to the inspirational quote messages.

Conclusions
No single type of digital message content universally promotes physical activity. Future work should evaluate the effects of multiple message types so that content can be continuously tuned based on person-specific responses to each message type.
The Chinese Version of the Breast Cancer Literacy Assessment Tool: Translation, Adaptation, and Validation Study
Authors: Shan Yi , Ji Meng 
Published: April 2023

Background
Breast cancer is the most common cancer among Chinese women, with an age-standardized prevalence of 21.6 cases per 100,000 women. Limited cancer health literacy reduces females’ ability to engage in cancer prevention and detection. It is necessary to assess Chinese women’s breast cancer literacy to deliver targeted interventions and effective education. However, there is no Breast Cancer Literacy Assessment Tool (B-CLAT) available in China currently.

Objective
This study aimed to translate and linguistically and culturally adapt the B-CLAT into a simplified-Chinese version (C-B-CLAT), and then validate its psychometric properties by administering it to Chinese college students.

Methods
First, we translated the B-CLAT into a simplified-Chinese version and verified its validity and reliability using rigorous translation and validation guidelines proposed in previous studies. We then evaluated the psychometric properties among 50 female participants with a mean age of 19.62 (SD 1.31) years recruited from Nantong University, China.

Results
Items 1, 6, 8, 9, 10, 16, 17, 20, 21, 22, 23, 24, 25, 26, 29, and 30 were deleted to increase the relevant subscale internal consistency. Items 3, 12, 13, 14, 18, 20, 27, and 31 were deleted due to their Cronbach α being lower than .5 in the test-retest analysis. After deletion, the internal consistency of the entire scale was fair with α=.607. The prevention and control subscale had the highest internal consistency with α=.730, followed by the screening and knowledge subscale with α=.509, while the awareness subscale had the lowest internal consistency with α=.224. The intraclass correlation coefficient for the C-B-CLAT (items 2, 4, 5, 7, 11, 15, 28, 32, 33, and 34) was fair to excellent (odds ratio [OR] 0.88, 95% CI 0.503-0.808). The values of Cronbach α for items 2, 4, 5, 7, 11, 15, 28, 32, 33, and 34 ranged from .499 to .806, and the α value for the C-B-CLAT was .607. This indicates fair test-retest reliability. The mean difference in the C-B-CLAT scores between stage 1 and stage 2 was 0.47 (OR 0.67, 95% CI −0.53 to 1.47), which was not significantly different from zero (t48=0.945; P=.35). This result implies that the C-B-CLAT produced the same scores at stage 1 and stage 2 on average, thus showing good agreement in the C-B-CLAT scores between stage 1 and stage 2. The SD of the difference was 3.48. The 95% limits of agreement were −6.34 to 7.28.

Conclusions
We developed a simplified-Chinese version of the B-CLAT through translation and adaptation. Psychometric properties testing has proven this version valid and reliable for assessing breast cancer literacy among Chinese college students.
Anomalias gravimetricas y espesor de corteza en la region de Oaxaca, México
Authors: Mena M. , De la Fuente M. , Morán D. , Espíndola J. M. , Nuñez-Cornú F. , Medina F. 
Published: April 2023

Se presentan los mapas gravimétricos de anomalías de Bouguer simple, de aire libre y residual isostático para el Estado de Oaxaca y zonas adyacentes (México). También se presenta un modelo de estructura de corteza para la costa de Oaxaca basado en los datos gravimétricos y en los perfiles sísmicos de refracción realizados durante 1987 en la costa sur del Pacífico Mexicano. Se utilizaron las velocidades sísmicas obtenidas en estos mismos perfiles para el cálculo de las densidades empleadas en la elaboración de los modelos de corteza.Los perfiles gravirnétricos reportados son los siguientes: Puerto Angel-Teotitlán del Camino, Puerto Ángel-Salina Cruz, y Puerto Ángel-Punta Maldonado.De Punta Maldonado a Salina Cruz se obtiene un espesor de corteza continental de 26.5 km en promedio, con densidades de 2.53 g/cm3 para Jos cuerpos superficiales y de 2.81 g/cm3 para los cuerpos profundos. En seguida se encuentra la corteza oceánica, con una densidad de 2.84 g/cm3 y 4 km de espesor, que se introduce por debajo de la corteza continental con un ángulo de subduc ción de 14.5° aproximadamente. Finalmente, en la base se encuentra el manto superior con una densidad de 3.21 g/cm3. En el modelo propuesto para el perfil Puerto Angel-Teotitlán del Camino encontramos un cuerpo con una densidad de 2.9 g/cm3 que podría corresponder a un cuerpo ígneo intrusivo de composición máfica. De Puerto Angel a Punta Maldonado se observa un horst delimitado por fallas en las partes laterales. En el perfil Puerto Angel-Salina Cruz se observa una depresión que sugiere la existencia de un graben.doi: sin doi
Accidental subdural block after epidural anesthesia in obstetric patient: Case report
Authors: Kesapragada Rajasekhar , Abdelmegeed Naema Ahmed , ALakkad Ashraf 
Published: April 2023

Background: Although often overlooked, subdural anesthesia is a relatively common complication. It can present with a wide range of symptoms, from unexpectedly high sensory and limited motor blocks to significant hemodynamic and respiratory effects.
Case Presentation: This case report documents the labor and delivery of a 26-year-old primigravida at 40 weeks gestation who requested an epidural at 4 cm. A 500 ml lactated Ringer's solution bolus was initiated prior to the procedure and a Tuohy needle, size 18-gauge, was utilized to locate the epidural space. Following a negative aspiration and falling meniscus test, a bolus of 8 ml containing a combination of 0.2% ropivacaine with 2 mcg/ml fentanyl was administered, resulting in a brief drop in blood pressure, which responded to ephedrine. An epidural infusion of 0.2% ropivacaine with 2 mcg/ml fentanyl was then started and continued until the decision was made to perform a caesarean section due to lack of progress. Prior to surgery, the epidural was supplemented with 15 ml of 0.75% ropivacaine and 50 mcg of fentanyl. Following the successful delivery of a healthy baby, the patient reported difficulty breathing, and her oxygen saturation dropped to 90%. She was intubated without medication and later extubated after the completion of surgery. The epidural provided pain relief for six hours postoperatively and the patient recovered fully without any neurological deficits.
Conclusion: The case report describes an epidural anesthesia that resulted in respiratory depression and unconsciousness without sympatholysis. The local anesthetic diffused into the dura- arachnoid interface, or the subdural space, which facilitated the movement of the anesthetic cephalad. However, the patient experienced complete neurological recovery. This case demonstrates the importance of careful monitoring and prompt intervention in the event of complications during epidural anesthesia.
Keywords: subdural anesthesia, primigravida, ropivacaine, unconsciousness.
The Role of the EAEU and the SCO in the Eurasia Environmental Safety Space Formation
Authors: Efremova M. S. 
Published: April 2023

Recently, most of the existing environmental problems have not only not been solved but have also worsened. There is a growing understanding in the public consciousness that the tools that have been used so far in solving these problems do not cope with the tasks formulated, among other things, in the UN Sustainable Development Goals. Accordingly, the interest in analyzing existing environmental problems and finding ways to solve them is taking an increasing place in the process of defining and implementing the policies of most states and their interaction with activists of environmental social movements.Aim. Development of new ideas and directions for improving environmental policy, including within the framework of increasing the intensity of integration processes in the Eurasian space covering the EAC and SCO countries.Tasks. In the article are analyzed the experience of EAC and SCO countries in the process of ecological safe space creation.Methods. In the article were used elements of comparative and systematic approaches and general scientific methods of analysis, synthesis, deduction, and induction.Results. The study revealed the need to consider new trends in the environmental policy of the Russian Federation also under development of integration processes within the Eurasian space from the perspective of political ecology.Conclusion. Based on the analysis, the following main environmental problems that exist in the Russian Federation were identified: waste management issues, water pollution, destruction of forests, skepticism about “alternative” and “green” energy. However, environmental problems, as a rule, affect more than one country, so they need to be solved through integration with other states. Now the development of a “green” economy is a promising direction within the Eurasian space.
Conjugation of the Integration Potentials of the Legal Framework of the EAEU and the CIS: Current State and Prospects for Improvement
Authors: Maryshev A. A. 
Published: April 2023

Aim. Give a reasoned assessment of the prospects for integration interaction between the Commonwealth of Independent States and the Eurasian Economic Union.Tasks. Tell about the beginning of the functioning of the Commonwealth of Independent States and give the structure of actually functioning bodies of the Commonwealth, substantiate the legitimacy of choosing the Eurasian Economic Union as a “hard core” of post-Soviet integration, assess the prospects of the idea of conjugation of the integration potentials of the CIS and the EAEU, tell about the joint work of the CIS and the EAEU to eliminate conflicts in their legal acts, substantiate the need for further work of the CIS and the EAEU within the framework of the emerging Greater Eurasian Partnership.Methods. To create the author’s version of the system of CIS bodies, institutional approaches were used in conjunction with structural and functional approaches. The “integration matryoshka” of the CIS — FTA — EAEU was built by the modeling method. Using the method of comparative analysis, the work of the working group on conjugation of the EAEU law and the legal framework of the CIS was analyzed. The forecasting method was used to justify the further work of the CIS and the EAEU within the framework of the emerging Greater Eurasian Partnership.Results. On the basis of specific examples, recommendations are given for combining soft and hard approaches for the development of the EAEU and the CIS with the prospect of building a Greater Eurasian Partnership in the future. Thus, the EAEU should pay attention to strengthening the supranational structure of the association, as well as to the practice of ASEAN dialogue mechanisms. At the same time, following the example of the EU, one should not create an excessive bureaucracy and exert excessive pressure on countries by interfering in their internal affairs.Conclusions. The contradiction between national and supranational interests is the most profound problem in any integration association, including the EAEU and the CIS. However, there is no universal method for solving this problem. The EAEU and the CIS should combine in their practice the experience of the EU and ASEAN as a hard and soft approach to balancing national and supranational interests.
The Specifics of the Internal Image of the People’s Republic of China in News Publications
Authors: Ivannikov N. S. , Pravdina E. E. 
Published: April 2023

This study is aimed to analyze the methods of forming the internal image of the People’s Republic of China in the domestic media as part of the coverage of an initially negative topic — the coronavirus epidemic, as well as characterizing the PRC’s strategy for positioning its own image.Aim. Reveal the specifics of the coverage of the COVID-19 epidemic, considering it as a method of forming the internal political image of the People’s Republic of China in the online news media.Tasks. Determine the techniques used by domestic news network media to form the state image among the audience, based on a content analysis of a corpus of Chinese articles on the topic of the coronavirus epidemic.Methods. In order to determine the specifics of the coverage of the epidemic in the Chinese media, a qualitative and quantitative content analysis was carried out using a set of parameters developed by the authors, which includes the possibility of sampling, lexical heading analysis, sentiment analysis, and frame analysis.Results. The government of the PRC is able to form a positive discourse in covering an initially negative situation, such as the spread of the COVID-19 virus and the resulting pandemic, which is fully reflected both in the headlines and in the tone of the texts and the use of certain frames. Such an opportunity is provided by such factors as: the state’s ability to control the press at a high level, the Golden Shield international information filtering system, which is specific to the People’s Republic of China, censorship and taboo coverage of a number of topics that are undesirable from the official point of view of the Communist Party of China.Conclusion. When analyzing the Chinese sample corpora, it was concluded that the Chinese government is pursuing a targeted policy to create a positive image through high control over local news publications. The internal image formation is in line with the concept of building a socialist society with Chinese characteristics, promoting the construction of a community of common destiny for mankind, fighting hegemony and imperialism in the world, resolutely defending national sovereignty, security and technological development, and promoting cooperation under the “One Belt, One Road” Initiative.