bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olivine‐Type MgMn0.5Zn0.5SiO4 Cathode for Mg‐Batteries: Experimental Studies and First Principles Calculations
Authors: Pérez‐Vicente Carlos , Rubio Saúl , Ruiz Rafaela , Zuo Wenhua , Liang Ziteng , Yang Yong , Ortiz Gregorio F. 
Published: January 2023

AbstractMagnesium driven reaction in olivine‐type MgMn0.5Zn0.5SiO4 structure is subject of study by experimental tests and density functional theory (DFT) calculations. The partial replacement of Mn in Oh sites by other divalent metal such as Zn to get MgMn0.5Zn0.5SiO4 cathode is successfully developed by a simple sol–gel method. Its comparison with the well‐known MgMnSiO4 olivine‐type structure with (Mg)M1(Mn)M2SiO4 cations distribution serves as the basis of this study to understand the structure, and the magnesium extraction/insertion properties of novel olivine‐type (Mg)M1(Mn0.5Zn0.5)M2SiO4 composition. This work foresees to extend the study to others divalent elements in olivine‐type (Mg)M1(Mn0.5M0.5)M2SiO4 structure with M = Fe, Ca, Mg, and Ni by DFT calculations. The obtained results indicate that the energy density can be attuned between 520 and 440 W h kg−1 based on two properties of atomic weight and redox chemistry. The presented results commit to open new paths toward development of cathodes materials for Mg batteries.
A case of rapid canine nephroblastoma presumed metastasis documented with advanced imaging
Authors: Seddon Kathleen , Smith Patrick , Romine Jessica 
Published: January 2023

AbstractA 1.5‐year‐old, female, entire German shepherd dog was presented for evaluation of an abdominal mass. The dog had a 4‐month history of polydipsia, polyuria, diarrhoea, and weight loss despite polyphagia. Abdominal ultrasound confirmed a large abdominal mass suspected to be uterine in origin. An exploratory celiotomy revealed a 4.3 kg, 26 × 17 × 17 cm multinodular mass entirely encompassing the uterus, left ovary and left kidney. A combined ovariohysterectomy and left nephrectomy were undertaken. Histopathology confirmed stage ΙΙ renal nephroblastoma with favourable histology. Chemotherapy was declined and 86 days following surgery, significant abdominal metastases were identified on a computed tomography scan. The patient was euthanased 113 days after surgery due to progressive disease. This is the first report to display the rapid presumed metastasis of a canine nephroblastoma, without gross metastasis at initial surgical resection, through advanced imaging. This is also the first reported case of polyphagia despite weight loss as a presenting clinical sign.
Introduction: Inhabiting Vulnerability Throughout the Life Course
Authors: Spini Dario , Widmer Eric 
Published: January 2023

AbstractThis chapter presents the vulnerability framework used in the different sections chapters of this book. Vulnerability is defined as a process of resource loss in one or more life domains that threatens individuals in three major steps: (1) an inability to avoid individual, social or environmental stressors, (2) an inability to cope effectively with these stressors, and (3) an inability to recover from stressors or to take advantage of opportunities by a given deadline. The chapter also stresses the importance of resources, reserves and stressors to understand the dynamics of vulnerability throughout the life span. This life course perspective of vulnerability processes is better understood through three main perspectives: multidimensional (across life domains), multilevel (using micro, meso and macro perspectives) and multidirectional (the study of vulnerability life trajectories should envisage all possible directions, namely stability, decline, recovery, growth trajectories and in long-term). We also argue in this chapter that a vulnerability framework enables researcher to understand the craft of our lives and the responses, be they individual (through agency), collective (through support) or institutional (social policies) that can be given to life events, life transitions, and to the stressors that individuals inevitably face sooner or later in their life.
How Family and Other Close Ties Shape Vulnerability Processes
Authors: Rossier Clémentine , Bernardi Laura , Baersywil Marie , Oris Michel , Sapin Marlène , Widmer Eric 
Published: January 2023

AbstractWhile close relations include both intimate family members and close friends, the transmission of socioeconomic resource remains largely confined within families. Moreover, family-transmitted values and sociopsychological skills are incorporated during childhood, and emotional and instrumental support is still mainly assumed by family members. These overlapping exchanges mean that family ties constitute durable resource for individuals, but that families are (also) damaging in case of tie dissolution, poor relational quality or gendered family practices. In this chapter, we examine how family and friends affect vulnerability processes differently by using three longitudinal datasets on long-term couples, lone parents, and ageing individuals, as well cross-sectional data on adults’ personal networks, collected with support from LIVES. We found that ambivalent and sometimes negative (i.e., resource depletion) aspects of family relationships emerge, in particular, in situations in which other key resources (including friendship ties) are missing, typically with the occurrence of stressful life events. Conversely, negative family events are more quickly overcome when sufficient resources (including friends) are available. Interestingly, some negative life events, such as job loss, are better dealt with through sparser personal networks. By contrast, normative life events act as densifiers or enlargers of both elective and family networks.
Synthesis: Vulnerability in Context
Authors: Spini Dario , Vacchiano Mattia 
Published: January 2023

AbstractVulnerability lies in the articulation of different levels. Constraints or opportunities, resources or stressors to people’ lives unfold at the intersection of micro-individual processes and macro-structural levels during the life course. This section explores five directions through which LIVES addresses these interactions across different meso-level contexts: (1) Vandecasteele and colleagues explain how socio-economic inequalities are structured across neighborhoods and communities, emphasising the importance of geographical contexts; (2) Hoffman and colleagues study inequalities in mental health by considering people’s relational contexts and the interaction between their networks and their social identities; (3) Bonvin and colleagues explain how the implementation of social policies depends on the functioning of organisations and the working conditions of those social agents who are in contact with vulnerable groups; (4) Burton-Jeangros and Vagnoli look at how the vulnerability of HIV-positive women is influenced and negotiated within medical and institutional contexts; (5) Rossier and colleagues focus on the importance of the family context and the structure of opportunities and constraints it provides during the life course. Together, looking at urban, relational and organisational contexts, these studies show important facets of vulnerability at the meso level.
Childhood Socioeconomic Disadvantage and Health in the Second Half of Life: The Role of Gender and Welfare States in the Life Course of Europeans
Authors: Cullati Stéphane , Sieber Stefan , van der Linden Bernadette Wilhelmina Antonia , Orsholits Dan , von Arx Martina , Boisgontier Matthieu P. , Cheval Boris 
Published: January 2023

AbstractResources and reserves influence the development of vulnerability in old age. When individuals lack resources throughout their life trajectories, or when they lack reserves to cope with unforeseen events, they become at risk of poor health in old age. The LIFETRAIL project, funded by the NCCR LIVES, examined the life course precursors—especially during childhoohevald—of health in old age. This chapter reviews the findings from the LIFETRAIL project with a reserve’s perspective. First, it describes the role of educational achievements as a potential life course mediator that can reduce the impact of childhood misfortune on health in older age. Second, it considers the role of welfare states as a proxy of structural protection against the risk of socioeconomic adversities during the life course and examine their protecting role on health in old age. Third, it provides empirical analyses describing the potential interactions between education and welfare state on health in old age.
Life Calendars for the Collection of Life Course Data
Authors: Morselli Davide , Berchtold André 
Published: January 2023

AbstractLife course studies involve the use of longitudinal data. Focusing on vulnerability processes that unfold in the medium or long term only reinforces this use, by requiring long sequences of data. However, traditional prospective data collection methods are not always compatible with restricted research time. The alternative is to collect retrospective data, sometimes in combination with prospective ones, and life calendars are a tool of choice for this kind of task. Although several methodological studies have shown that calendar data outperform conventional retrospective question lists, the quality of retrospective and prospective data is likely not to be the same. Hence, it is crucial to develop life calendars able to enhance the correct recall of past information, and to be able to demonstrate the accuracy of the resulting data. Moreover, with the advent of online data collection, the perspective to replace paper-and-pencil life calendars by electronic ones, and to make them self-administered, could help generalize this kind of data collection, but it also implies additional challenges. This chapter draws on several experiments with life calendars performed within the NCCR LIVES. It shows that life calendars can capture accurate data, and that online calendars have now become more than just a possibility.
Combining Event History and Sequence Analysis to Study Vulnerability over the Life Course
Authors: Studer Matthias , Gauthier Jacques-Antoine , Le Goff Jean-Marie 
Published: January 2023

AbstractThe life-course paradigm insists on the need to study trajectories and how they unfold over time. Two broad families of methodological strategies are generally used for this purpose. The first strategy focuses on the occurrence of events or transitions describing the dynamics of life trajectories. The second strategy emphasizes the holistic nature of trajectories or processes of categorical states by relying on sequence analysis. This chapter reviews recent methodological development combining these two approaches often presented as irreconcilable. “Competing Trajectory Analysis” aims to analyze jointly the occurrence of an event and the “trajectory” that immediately follows it. On the other hand, the “Sequence History Analysis” approach uses sequence analysis to better describe how an unfolding trajectory is linked with the occurrence of an upcoming event. The chapter proposes a theoretical presentation of these approaches discussing their respective strength and weaknesses for life-course research and more specifically the study of vulnerability over the life course. The added value of each approach is illustrated through a study of the relationship between divorce and professional trajectories using the retrospective data from the Swiss Household Panel.
Synthesis: Combining Methods for the Analysis of Vulnerability Processes Across the Life Course
Authors: Berchtold André , Ghisletta Paolo 
Published: January 2023

AbstractThe analysis of vulnerability processes throughout life implies several methodological difficulties. In this review chapter, we look back on more than 10 years of methodological innovations developed within the NCCR LIVES. Concerning data collection issues, although the prospective survey remains the gold standard for obtaining longitudinal data, retrospective data collected through specially adapted tools such as life calendars allow for a rapid completion of data sequences. Moreover, alternative sampling schemes based on network methods can reach individuals not likely to be included in traditional probabilistic samples. This also requires the development and use of more global data collection modes, combining qualitative and quantitative data, and allowing participants to respond in the manner best suited to their specific situations and capacities. What is true regarding data collection is also a requirement for data analysis: it is often essential to combine the strengths of different analytical tools such as traditional longitudinal analyses and survival analysis, the aim being to study the occurrence of specific events without losing sight of an individual’s prior trajectories over their life course. Finally, the chapter also addresses the issues of multichannel analyses and missing data.
When Mobility Meets Gender in the Transnational Life-Course
Authors: Le Feuvre Nicky , Davoine Eric , Cangià Flavia 
Published: January 2023

AbstractThis chapter explores the spillover effects of transnational mobility on professional and private life spheres, paying particular attention to the gender dynamics of vulnerability. From an interdisciplinary perspective, our aim is to explore the vulnerabilities associated with various forms of geographical mobility in societies (see Forbes-Mewett, 2020) characterised by increasing levels ofspatial displacement (Cresswell, 2006; Kaufmann, 2020) and by uneven shifts in gender norms across countries and among social groups (Bornatici et al., 2021; Daly, 2020; Esping-Andersen, 2009). We define transnational mobility as a physical displacement across borders that is imbued with a wide array of meanings, imaginaries and practices (Frello, 2008; Salazar & Smart, 2011). As a complex human experience, mobility is always entangled with other aspects of the life course (Cangià, 2021). Here, we are particularly interested in the interplay between the experience of transnational mobility, including different forms of short- or longterm cross-border relocation, and the gender configurations of professional and family life. Our empirical studies cover a diverse selection of geographically mobile and immobile people, including those who are commonly associated with privileged forms of transnational movement (Amit, 2011) and those who are often perceived as more constrained movers.
Social Policies, Vulnerability and the Life Course: A Complex Nexus
Authors: Bonvin Jean-Michel , Tabin Jean-Pierre , Perriard Anne , Rosenstein Emilie , Lovey Max 
Published: January 2023

AbstractSocial policies are designed to tackle vulnerability processes, providing additional resources to vulnerable target groups and helping them overcome stressing situations. However, empirical observations have shown that social policies may also reinforce vulnerability in certain cases. This can be better explained if one considers vulnerability as a multi-level process. Vulnerability is experienced by individuals at micro-level: it is then characterised by multidimensionality where diverse spheres of life can be affected; vulnerability is then framed as a social issue at macro level, requiring the setting up of adequate policy; this macro notion of vulnerability is then implemented at meso-level by agents that are called to translate the macro level notion of vulnerability into actual public action. There may be a gap or a discrepancy between the different notions of vulnerability as experienced at micro level, framed as social problem at macro level and implemented as public action at meso level. This gap may result in paradoxical situations where social policies do not provide adequate resources or submit their access to stringent conditions acting as stressors, thus reinforcing cumulative disadvantage rather than counteracting it. Examples from studies conducted within the NCCR-LIVES illustrate some of these paradoxical situations.
Exploring the potential of FCC-hh to search for particles from B mesons
Authors: Boyarsky Alexey , Mikulenko Oleksii , Ovchynnikov Maksym , Shchutska Lesya 
Published: January 2023

Abstract
The Future Circular hadron Collider (FCC-hh) is a proposed successor of the Large Hadron Collider (LHC). FCC-hh would push both the energy and intensity frontiers of searches for new physics particles. In particular, due to higher energy and luminosity than at the LHC, at FCC-hh there would be produced around ≃ 30 times larger amount of B mesons and ≃ 120 times of W bosons, which then may decay into feebly interacting particles. In this paper we demonstrate the potential of FCC-hh by studying its sensitivity to heavy neutral leptons (HNLs) with masses mN< mB. We consider various locations of a displaced decay volume embedded in the planned infrastructure of FCC-hh. We demonstrate that FCC-hh may substantially improve the reach of the parameter space of HNLs as compared to the searches proposed at the LHC.
Kindliche vordere Kreuzbandruptur mit komplexer Außenmeniskusverletzung und Knorpelfragmentablösung der posterolateralen Tibia
Authors: Szalay Alexander , Runer Armin , Ehmann Yannick , Imhoff Andreas B. , Mehl Julian , Achtnich Andrea 
Published: January 2023

ZusammenfassungEin 11-jähriger Junge erleidet ein Distorsionstrauma des Kniegelenks mit einer Ruptur des vorderen Kreuzbands (VKB), Läsion des Außenmeniskus und Ablösung eines Knorpelfragments am posterolateralen Tibiaplateau. Aufgrund der konträren Nachbehandlungsschemata dieser schwerwiegenden Kombinationsverletzung erfolgt eine zweizeitige operative Versorgung. In einem ersten arthroskopischen Eingriff werden die Meniskus- und Knorpelverletzung behandelt. Nach stattgefundener Knorpeleinheilung erfolgt eine epiphysenschonende Rekonstruktion des vorderen Kreuzbands.
Pea protein–sugar beet pectin binders can provide cohesiveness in burger type meat analogues
Authors: Moll Pascal , Salminen Hanna , Schmitt Christophe , Weiss Jochen 
Published: January 2023

AbstractMethylcellulose is commonly used in meat analogues for binding ingredients. In this study, we compared the binding properties of a methylcellulose hydrogel (5% w/w) to a novel, clean-label binder based on a mixture of pea protein and sugar beet pectin (r = 2:1, 22.5% w/w, pH 6.0) with and without laccase addition in a burger type meat analogue. It was shown that the pea protein–pectin binder glued vegetable protein particles and fat mimic particles together prior to cooking and frying, thereby improving forming of the mass into burger patties. Furthermore, sensory analysis revealed that the cohesiveness of the fried burger patties was better when the protein–pectin binder was used. However, the used binder system did not affect the hardness of the burger patties indicating that the binders rather affected the coherence of the structural elements. Burgers with solid fat particles were rated better in terms of appearance as compared to emulsified fat particles, since the former were not visible. This study is useful to better understand meat analogue product design for a higher acceptance among consumers.
Comparing anticipatory and stop-signal response inhibition with a novel, open-source selective stopping toolbox
Authors: Wadsley Corey G. , Cirillo John , Nieuwenhuys Arne , Byblow Winston D. 
Published: January 2023

AbstractResponse inhibition is essential for terminating inappropriate actions and, in some cases, may be required selectively. Selective stopping can be investigated with multicomponent anticipatory or stop-signal response inhibition paradigms. Here we provide a freely available open-source Selective Stopping Toolbox (SeleST) to investigate selective stopping using either anticipatory or stop-signal task variants. This study aimed to evaluate selective stopping between the anticipatory and stop-signal variants using SeleST and provide guidance to researchers for future use. Forty healthy human participants performed bimanual anticipatory response inhibition and stop-signal tasks in SeleST. Responses were more variable and slowed to a greater extent during the stop-signal than in the anticipatory paradigm. However, the stop-signal paradigm better conformed to the assumption of the independent race model of response inhibition. The expected response delay during selective stop trials was present in both variants. These findings indicate that selective stopping can successfully be investigated with either anticipatory or stop-signal paradigms in SeleST. We propose that the anticipatory paradigm should be used when strict control of response times is desired, while the stop-signal paradigm should be used when it is desired to estimate stop-signal reaction time with the independent race model. Importantly, the dual functionality of SeleST allows researchers flexibility in paradigm selection when investigating selective stopping.
Differentiability Properties for Boundary Control of Fluid-Structure Interactions of Linear Elasticity with Navier-Stokes Equations with Mixed-Boundary Conditions in a Channel
Authors: Hintermüller Michael , Kröner Axel 
Published: January 2023

AbstractIn this paper we consider a fluid-structure interaction problem given by the steady Navier Stokes equations coupled with linear elasticity taken from (Lasiecka et al. in Nonlinear Anal 44:54–85, 2018). An elastic body surrounded by a liquid in a rectangular domain is deformed by the flow which can be controlled by the Dirichlet boundary condition at the inlet. On the walls along the channel homogeneous Dirichlet boundary conditions and on the outflow boundary do-nothing conditions are prescribed. We recall existence results for the nonlinear system from that reference and analyze the control to state mapping generalizing the results of (Wollner and Wick in J Math Fluid Mech 21:34, 2019) to the setting of the nonlinear Navier-Stokes equation for the fluid and the situation of mixed boundary conditions in a domain with corners.
Improved benefit of continuing luspatercept therapy: sub-analysis of patients with lower-risk MDS in the MEDALIST study
Authors: Germing Ulrich , Fenaux Pierre , Platzbecker Uwe , Buckstein Rena , Santini Valeria , Díez-Campelo María , Yucel Aylin , Tang Derek , Fabre Shannon , Zhang George , Zoffoli Roberto , Ha Xianwei , Miteva Dimana , Hughes Christina , Komrokji Rami S. , Zeidan Amer M. , Garcia-Manero Guillermo 
Published: January 2023

AbstractRed blood cell transfusion independence (RBC-TI) is an important goal in treating lower-risk myelodysplastic syndromes with ring sideroblasts. In the phase 3 MEDALIST study, RBC-TI of ≥ 8 weeks was achieved by significantly more luspatercept- versus placebo-treated patients in the first 24 weeks of treatment. In this post hoc analysis, we evaluated RBC transfusion units and visits based on patients’ baseline transfusion burden level and the clinical benefit of luspatercept treatment beyond week 25 in initial luspatercept nonresponders (patients who did not achieve RBC-TI ≥ 8 weeks by week 25) but continued luspatercept up to 144 weeks. RBC transfusion burden, erythroid response, serum ferritin levels, and hemoglobin levels relative to baseline were evaluated. Through week 25, fewer RBC transfusion units and visits were observed in luspatercept-treated patients versus placebo, regardless of baseline transfusion burden. This continued through 144 weeks of luspatercept treatment, particularly in patients with low baseline transfusion burden. Sixty-eight patients were initial nonresponders at week 25 but continued treatment; most (81%) received the maximum dose of luspatercept (1.75 mg/kg). Sixteen percent achieved RBC-TI for ≥ 8 weeks during weeks 25–48, 26% had reduced RBC transfusion burden, 10% achieved an erythroid response, 44% had reduced serum ferritin, and hemoglobin levels increased an average of 1.3 g/dL from baseline. These data have implications for clinical practice, as transfusion units and visits are less in luspatercept-treated patients through week 25 regardless of baseline transfusion burden, and continuing luspatercept beyond week 25 can potentially provide additional clinical benefits for initial nonresponders. Trial registration: NCT02631070.