bluuebunny/crossref_metadata_2025_split huggingface dataset:
National Treatment Patterns and Outcomes for Hospitalized Patients with Chronic Limb-Threatening Ischemia and End-Stage Kidney Disease
Authors: Shah Samir K. , Neal Dan , Berceli Scott A. , Segal Mark , Cooper Michol A. , Huber Thomas S. , Upchurch Gilbert R. , Scali Salvatore T. 
Published: December 2022

Background Chronic limb-threatening ischemia (CLTI) can be associated with dismal outcomes but there are limited real-world data to further define the impact of end-stage kidney disease (ESKD) on outcomes nationally in this subset of patients. We sought to characterize national patterns of inpatient treatment of CLTI and compare outcomes in patients without ESKD. Methods The National Inpatient Sample was queried from 2015-2018 for all hospital admissions including treatment for CLTI. Mixed-effects linear and logistic regression models were used to estimate the effect of ESKD on outcomes and treatment choice. Results We identified 11 652 hospital admissions with CLTI alone and 2705 with CLTI + ESKD. Hospital admissions with CLTI + ESKD patients included patients who were younger (66 vs 69 years, P < .0001), less likely to be white (39% vs 63%, P < .0001), and more likely to reside in lower income large metropolitan areas. Admissions for CLTI + ESKD patients had a lower likelihood of open arterial reconstruction (OR .40, P < .0001) and a higher likelihood of endovascular revascularization or major limb amputation (OR 1.70, P < .0001). Admissions for CLTI + ESKD also had a 4.5- and 1.5-fold higher odds of in-hospital death and complications. These findings were associated with a longer LOS ( P < .0001), increased probability of discharge to rehabilitation facility (50% vs 41%, P < .0001), and greater hospital charges (median, $107 K vs $85 K, P < .0001). Conclusions Compared to hospital admissions for patients without ESKD, admissions for patients with CLTI + ESKD demonstrated distinctive demographic characteristics, a lower likelihood of open revascularization and a higher likelihood of endovascular revascularization and major limb amputation. Chronic limb-threatening ischemia + ESKD hospital admissions showed worse overall outcomes and greater resource utilization compared to CLTI admissions without ESKD.
Left Internal Mammary Artery Operative Topography for MIDCAB and TECAB Procedures
Authors: Rams Daniel , Batko Jakub , Bartuś Krzysztof , Filip Grzegorz , Kowalewski Mariusz , Litwinowicz Radosław 
Published: December 2022

Objective: The left internal mammary artery (LIMA) is a common arterial graft in minimally invasive coronary surgery (MICS), such as minimally invasive coronary artery bypass grafting (MIDCAB) or totally endoscopic coronary artery bypass (TECAB). The aim of this study was to perform an analysis of the LIMA operative topography during MICS. Methods: A total of 104 computed tomography angiographies were analyzed retrospectively using 3-dimensional reconstruction and visualization software. Measurements were developed in relation to the anatomical midpoint of the sternal body (SBMP). Parameters were evaluated as lengths, distances, diagonals, or categorical descriptions. Results: A total of 208 internal mammary arteries of each side were analyzed with the following results: (1) LIMA width = 2.7 mm, (2) SBMP–LIMA bifurcation length = 6.2 cm, (3) SBMP–LIMA distance = 3.2 ± 0.5 cm, (4) xiphoid midpoint–LIMA distance = 3.5 ± 0.7 cm, (5) sternal line–LIMA distance = 1.7 ± 0.3 cm, (6) xiphoid end projection–LIMA bifurcation length = 2.2 ± 1.0 cm, (7) midsternal line–LIMA bifurcation distance = 3.3 ± 0.8 cm, (8) xiphoid end–LIMA bifurcation diagonal = 4.1 ± 0.9 cm, (9) LIMA–left coronary artery distance = 7.0 ± 1.4 cm at the proximal and 7.1 ± 1.3 cm at the distal segment, and (10) LIMA–left anterior descending artery distance = 5.5 ± 1.1 cm at proximal, 4.3 cm at middle, and 4.2 ± 1.5 cm at distal segment. The extent of LIMA bifurcation ranged from the level of 5 (1%) to 7 (6%) rib cartilages. Conclusions: Based on the detailed surgical anatomy of LIMA, it was concluded that the fourth intercostal space should be considered as an appropriate approach for MIDCAB or TECAB in the studied region.
Type of Work and Preoperative Ability to Perform Work Affect Return to Usual Work Following Proximal Interphalangeal Joint Arthroplasty for Osteoarthritis
Authors: Notermans Bo J. W. , Teunissen Joris S. , Selles Ruud W. , de Boer Luitzen H. L. ,   the Hand Wrist Study Group, van der Heijden Brigitte E. P. A. 
Published: December 2022

Background: The time until return to work (RTW) and possible factors affecting this time after proximal interphalangeal (PIP) joint arthroplasty are unknown. Therefore, we aim to evaluate the RTW after PIP joint arthroplasty for osteoarthritis and assess factors affecting the time until return to their usual work. Methods: We used prospectively gathered data from 74 patients undergoing PIP joint arthroplasty with daily hand surgery practice routine outcome collection. Standardized RTW questionnaires were completed at 6 weeks and 3, 6, and 12 months after surgery. Return to work was defined as the first time a patient reported returning to work and performing the original work for a minimum of 50% of the original hours a week, as stated in the patient’s contract. Second, we evaluated baseline factors affecting the time until RTW. Results: The probability of RTW within 12 months after surgery was 88%. The median time until RTW was 8 weeks (interquartile range: 4-10). Physical occupational intensity (hazard ratio [HR]: 0.36, P = .001) and the baseline Michigan Hand Outcomes Questionnaire work scores (HR: 1.02, P = .005) were independently associated with RTW. Conclusion: In conclusion, patients returned to work after a median of 8 weeks following PIP arthroplasty. Patients with medium or heavy physical occupations returned to work later than patients with light physical occupations. Better patient-reported work outcomes at baseline also led to an earlier RTW. This information can be valuable for providing adequate information during the preoperative consultation.
“It’s a lonely battle”: A qualitative study of older adult Canadians’ experiences with chronic obstructive pulmonary disease medication adherence and support
Authors: Skerry Leanne , Kervin Emily , Freeze Tracy A. , Brillant Andrew , Woodland Jennifer , Hanson Natasha 
Published: December 2022

Background: Medication adherence is critical for optimal management of chronic obstructive pulmonary disease (COPD) and is influenced by patient, treatment and societal factors. Currently, little is known about the patient perspectives of older adult Canadians with COPD regarding medication adherence. Therefore, the purpose of this study was to explore the lived experiences of older Canadian adults with COPD regarding medication adherence and management. Methods: Semi-structured interviews were conducted with 20 community-dwelling older adults with COPD, and iterative thematic analysis was performed. Results: Six themes emerged from these data: (1) continuity of care, (2) importance of pharmacy for information and care, (3) medication self-management, (4) “there needs to be more information,” (5) drug costs a concern and (6) “it’s a lonely battle.” Conclusion: Findings suggested a need for improved continuity of care, disease-related information provision and means of addressing psychosocial needs. Holistic approaches to patient education and self-management, with consideration for varying health literacy, are needed.
Design and logistical considerations for the randomized adaptive non-inferiority storage-duration-ranging CHIlled Platelet Study
Authors: Zantek Nicole D , Steiner Marie E , VanBuren John M , Lewis Roger J , Berry Nicholas S , Viele Kert , Krachey Elizabeth , Dean J Michael , Nelson Stacy , Spinella Philip C 
Published: December 2022

Background: Platelet transfusion is a potentially life-saving therapy for actively bleeding patients, ranging from those undergoing planned surgical procedures to those suffering unexpected traumatic injuries. Platelets are currently stored at room temperature (20°C–24°C) with a maximum storage duration of 7 days after donation. The CHIlled Platelet Study trial will compare the efficacy and safety of standard room temperature–stored platelets with platelets that are cold-stored (1°C–6°C), that is, chilled, with a maximum of storage up to 21 days in adult and pediatric patients undergoing complex cardiac surgical procedures. Methods/Results: CHIlled Platelet Study will use a Bayesian adaptive design to identify the range of cold storage durations for platelets that are non-inferior to standard room temperature–stored platelets. If cold-stored platelets are non-inferior at durations greater than 7 days, a gated superiority analysis will identify durations for which cold-stored platelets may be superior to standard platelets. We present example simulations of the CHIlled Platelet Study design and discuss unique challenges in trial implementation. The CHIlled Platelet Study trial has been funded and will be implemented in approximately 20 clinical centers. Early randomization to enable procurement of cold-stored platelets with different storage durations will be required, as well as a platelet tracking system to eliminate platelet wastage and maximize trial efficiency and economy. Discussion: The CHIlled Platelet Study trial will determine whether cold-stored platelets are non-inferior to platelets stored at room temperature, and if so, will determine the maximum duration (up to 21 days) of storage that maintains non-inferiority. Trial registration: ClinicalTrials.gov, NCT04834414
Exploring perceived stress from caring for coronavirus disease (COVID-19) patients in nurses: a qualitative study
Authors: Pourgholam Nima , Zareiyan Armin , Farsi Zahra , Abbasiyan Koorosh 
Published: December 2022

Background: The coronavirus pandemic has increased the perceived stress among people worldwide. The new coronavirus issue has recently put nursing staff under severe stress. Aims: This study aimed to evaluate the stress perceived by nurses in caring for new coronavirus patients. Methods: This qualitative conventional content analysis was conducted from February and March 2021. Twelve nurses working in the inpatient care wards for COVID-19 patients in Tehran hospitals were enrolled using purposive sampling. Data were collected through in-depth and semi-structured interviews and collection continued until reaching data saturation. All interviews were recorded, transcribed, reviewed and analysed using the Graneheim and Lundman method. Results: One main category, five categories and 19 sub-categories emerged from the data. The nurses experienced ‘the process of transition from unknown conditions’. Caregiving stress, impression on all aspects of life, COVID as a strange disease, stress caused by patient characteristics and stress reduction over time were issues in the formation of stress in nurses caring for patients with COVID-19. Conclusions: The findings indicated that nurses caring for COVID-19 patients experience varying levels of stress for a variety of interrelated reasons. Knowing how nurses perceive the stress of caring for patients with COVID-19 can aid in the development of practical steps to reduce stress and make nurses more comfortable.
Cancer immune profiling unveils biomarkers, immunological pathways, and cell type score associated with glioblastoma patients’ survival
Authors: Moreno Daniel Antunes , da Silva Luciane Sussuchi , Gomes Isabella , Leal Letícia Ferro , Berardinelli Gustavo Noriz , Gonçalves Gisele Melo , Pereira Caio Augusto , Santana Iara Viana Vidigal , Matsushita Marcus de Medeiros , Bhat Krishna , Lawler Sean , Reis Rui Manuel 
Published: December 2022

Introduction: Glioblastoma (GBM), isocitrate dehydrogenase ( IDH) wild-type ( IDHwt), and grade 4 astrocytomas, IDH mutant ( IDHmut), are the most common and aggressive primary malignant brain tumors in adults. A better understanding of the tumor immune microenvironment may provide new biomarkers and therapeutic opportunities. Objectives: We aimed to evaluate the expression profile of 730 immuno-oncology-related genes in patients with IDHwt GBM and IDHmut tumors and identify prognostic biomarkers and a gene signature associated with patient survival. Methods: RNA was isolated from formalin-fixed, paraffin-embedded sections of 99 tumor specimens from patients treated with standard therapy. Gene expression profile was assessed using the Pan-Cancer Immune Profiling Panel (Nanostring Technologies, Inc., Seattle, WA, USA). Data analysis was performed using nSolverSoftware and validated in The Cancer Genome Atlas. In addition, we developed a prognostic signature using the cox regression algorithm (Least Absolute Shrinkage and Selection Operator). Results: We found 88 upregulated genes, high immunological functions, and a high macrophage score in IDHwt GBM compared to IDHmut tumors. Regarding IDHwt GBM, we found 24 upregulated genes in short-term survivors (STS) and overexpression of CD274 (programmed death-ligand 1, PD-L1). Immune pathways, CD45, cytotoxic, and macrophage scores were upregulated in STS. Two different prognostic groups were found based on the 12-gene signature (CXCL14, PSEN2, TNFRSF13C, IL13RA1, MAP2K1, TNFSF14, THY1, CTSL, ITGAE, CHUK, CD207, and IFITM1). Conclusion: The elevated expression of immune-oncology-related genes was associated with worse outcome in IDHwt GBM patients. Increased immune functions, CD45, cytotoxic cells, and macrophage scores were associated with a more aggressive phenotype and may provide promising possibilities for therapy. Moreover, a 12 gene-based signature could predict patients’ prognosis.
Trends of intrauterine device insertion and ‘Googling’ about intrauterine devices before and during the COVID-19 pandemic in Australia
Authors: D’Arcy Sarah , Cao Chester , Ahn Steve , Allan Victoria , Ahmadvand Alireza 
Published: December 2022

Objective The COVID-19 pandemic significantly disrupted access to primary care in Australia. This could have negatively impacted reproductive health services rates such as intrauterine device insertion rates, and interest in seeking information about intrauterine devices by searching on Google. We aimed to assess the trends of, and the association between, the actual Medicare service utilization rates for intrauterine device insertion and searching about intrauterine devices on Google, before and during the COVID-19 pandemic. Methods We conducted systematic analyses of secondary data from June 2017 to May 2022, using Medicare and Google Trends data sources. We visualized the rates of intrauterine device insertion, plus Google's search volumes about ‘Intrauterine device’ and ‘Progestin IUDs’ as topics. Then, we assessed the correlation between intrauterine device insertion rates and Google search, using Spearman correlation. Results The average yearly rates of intrauterine device insertion increased noticeably from 25.1–26.3 in 2018–2019 to 29.3–31.2 per 100,000 population in 2020–2021 (12–18% increase). The highest monthly intrauterine device insertion rate nationally (37 per 100,000 population) was seen in March 2021. By June 2020, search term use for the two intrauterine device-related topics returned to much higher levels (50% increase for ‘Progestin IUDs’, and 54% for ‘Intrauterine device’, respectively). A moderately strong correlation was seen between actual intrauterine device insertion rates and search on Google about intrauterine devices (Spearman rho = 0.61, p < 0.000). Conclusion We demonstrated a moderately strong correlation between trends of intrauterine device insertion rates and search on Google about intrauterine devices, before and during the COVID-19 pandemic in Australia. Googling about intrauterine devices could, therefore, be a useful indicator to gauge future interest in actual intrauterine device insertion for months thereafter.
What Knowledge is of Most Worth? Considering the Neo-Confucians in the Contemporary Debate Between Moral and Intellectual Learning
Authors: Shekitka John Patrick 
Published: December 2022

Highlights The perennial debate regarding the relative usefulness of various forms of knowledge, especially between the theoretical and practical and the intellectual and moral, lies at the heart of education in both past and present times in both the West and China (de Bary, 1988, 2004, 2005, 2015). Neo-Confucians remain relevant in the 21st century and can help us to understand and elucidate contemporary debates in education—specifically, to answer the question Spencer asked nearly a century and a half ago: “What knowledge is of most worth?”. Mencius, Zhu Xi, Wang Yangming, Xu Ai, and Kang Youwei advocated for a type of learning that would strongly resonate with John Dewey (1938) and Paulo Freire (1970, 1978). Foundational philosophies of education, particularly in the United States, have drawn heavily on 20th century European-American thinkers; this article attempts to correct this myopia and broaden perspectives.
Thermal investigation and physiochemical interaction of H2O and C2H6O2 saturated by Al2O3 and γAl2O3 nanomaterials
Authors: M. Alharbi Khalid Abdulkhaliq , Adnan  
Published: December 2022

Applications: The interaction of nanoparticles and base solvents of different nature attained much interest of the researchers in the recent time. These use in medication, detection of cancer cells, applied thermal engineering, and electrical and mechanical engineering. Among the broad range of applications, investigation of nanofluid through converging/diverging channel is important which is of much interest in the field of medical sciences. Purpose and methodology: The core purpose of this study is to introduce a new heat transfer model for two natures of nanofluids with bi host solvents. The model in hand achieved through nanofluid expressions, similarity equations and induction of novel dissipation effects. At later stage, numerical treatment is performed to explore the actual behaviour of nanofluids inside the oblique walls which is very important. Core findings: From the drawn results, it is found that the motion could be controlled by expanding the channel walls ([Formula: see text]) and high Re and in Al2O3-H2O it is optimum. The nanofluids based on Al2O3 and C2H6O2 have much ability to transmit heat than the other nanofluids. Moreover, dissipation effects ([Formula: see text]) played significant role and boosted the temperature while keeping [Formula: see text] and [Formula: see text], respectively. Also, the study is validated and achieved good agreement between existing and the current study.
Adverse Events in Patients Receiving Placebo in Phase III Trials of Biologics for Psoriasis: A Systematic Review and Meta-Analysis
Authors: Ajenthen Gayathri Devaraj , Egeberg Alexander , Melgaard Katrine Elsner , Loft Nikolai 
Published: December 2022

Background Patients and practitioners often consider the risk of side effects when starting a treatment for psoriasis and often consult reported adverse events (AE) in studies. However, most of these AEs are unrelated to treatment and patients consider what is the risk of an event should you not start a treatment. This is what would be observed in the placebo-arm of clinical trials. Objective To investigate the proportion of patients experiencing AEs during treatment with placebo in clinical trials. Methods We conducted a systematic literature search using PubMed, Embase and Web of Science databases for phase 3 randomized clinical trials that registered adverse events of using placebo vs biological agents for psoriasis. The search term was “ Psoriasis AND (Phase III OR Phase 3)”. Results Of 7142 screened articles, 54 were included in the metanalysis. The pooled proportion of placebo-treated patients experiencing any AEs was .52 (95% Cl: .51 to .53) after 12 weeks and .53 (95% Cl: .50 to .55) after 16 weeks. The pooled proportion of patients with any serious AEs was .02 (95% Cl: .01 to .02) and .03 (95% Cl: .02 to .03) after 12 and 16 weeks, respectively. The most common AEs in placebo-treated patients were infections, nasopharyngitis, and headache. Conclusion About half of the patients with moderate-to-severe psoriasis not starting an active treatment would experience disease events that would be categorized as AEs during a 12-16 weeks period.
The tetraspanin CD53 protects stressed hematopoietic stem cells via promotion of DREAM complex–mediated quiescence
Authors: Greenberg Zev J. , Paracatu Luana Chiquetto , Monlish Darlene A. , Dong Qian , Rettig Michael , Roundy Nate , Gaballa Rofaida , Li Weikai , Yang Wei , Luke Cliff J. , Schuettpelz Laura G. 
Published: December 2022

Abstract
The hematopoietic stem cell (HSC) cycle responds to inflammatory and other proliferative stressors; however, these cells must quickly return to quiescence to avoid exhaustion and maintain their functional integrity. The mechanisms that regulate this return to quiescence are not well understood. Here, we show that tetraspanin CD53 is markedly upregulated in HSCs in response to a variety of inflammatory and proliferative stimuli and that the loss of CD53 is associated with prolonged cycling and reduced HSC function in the context of inflammatory stress. Mechanistically, CD53 promotes the activity of the dimerization partner, RB-like, E2F, and multi-vulva class B (DREAM) transcriptional repressor complex, which downregulates genes associated with cycling and division. Proximity labeling and confocal fluorescence microscopy studies showed that CD53 interacts with DREAM-associated proteins, specifically promoting the interaction between Rbl2/p130 and its phosphatase protein phosphatase 2A (PP2A), effectively stabilizing p130 protein availability for DREAM binding. Together, these data identified a novel mechanism by which stressed HSCs resist cycling.
Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial
Authors: Burke G. A. Amos , Vinti Luciana , Kabickova Edita , Beishuizen Auke , Tacyildiz Nurdan , Uyttebroeck Anne , Kang Hyoung Jin , Luisi Flavio , Minard-Colin Véronique , Burkhardt Birgit , Tamegnon Monelle , Sun Steven , Curtis Madeliene , Deshpande Sanjay , Nottage Kerri , Howes Angela , Srinivasan Srimathi , Bhojwani Deepa , Norris Robin , Cairo Mitchell 
Published: December 2022

Abstract
Part 1 results of the open-label, randomized, global phase 3 SPARKLE trial supported continued assessment of ibrutinib with either modified rituximab, ifosfamide, carboplatin, and etoposide (RICE) or rituximab, vincristine, ifosfamide, carboplatin, idarubicin, and dexamethasone (RVICI) in pediatric patients with relapsed/refractory (R/R) mature B-cell non-Hodgkin lymphoma (B-NHL). We report final results of Part 2 evaluating the efficacy of ibrutinib plus RICE or RVICI vs RICE/RVICI alone. Patients aged 1 to 30 years (initial diagnosis &lt;18 years) were randomized 2:1 to receive ibrutinib with or without RICE/RVICI. Primary endpoint was event-free survival (EFS) based on independent committee-confirmed events. Fifty-one patients were enrolled. Median age was 15 years; Burkitt lymphoma, Burkitt leukemia, and Burkitt-like lymphoma (total: 45%) and diffuse large B-cell lymphoma/primary mediastinal B-cell lymphoma (51%) were the most common subtypes. At the preplanned interim analysis, median EFS was 6.1 vs 7.0 months with ibrutinib plus RICE/RVICI vs RICE/RVICI, respectively (hazard ratio, 0.9; 90% confidence interval, 0.5-1.6; P = .387); further enrollment was ceased. With ibrutinib plus RICE/RVICI vs RICE/RVICI, median overall survival was 14.1 vs 11.1 months, overall response rate was 69% vs 81%, and 46% vs 44% proceeded to stem cell transplantation. In both treatment arms, 100% of patients experienced grade ≥3 treatment-emergent adverse events. No EFS benefit was seen with ibrutinib. Salvage was generally poor in patients who received prior rituximab, regardless of treatment arm. No new safety signals were observed. Ibrutinib exposure in pediatric patients fell within the target range of exposure in adults. Trial is registered on www.clinicaltrials.gov (NCT02703272)