bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival rates of adult patients with Hodgkin lymphoma who underwent ABVD versus escalated BEACOPP in a resource‐limited country: An observational study
Authors: Suwanban Tawatchai , Chamnanchanunt Supat , Thungthong Pravinwan , Nakhahes Chajchawan , Iam‐arunthai Kunapa , Akrawikrai Tananchai , Bunworasate Udomsak 
Published: May 2023

AbstractBackgroundThe survival rate of adult patients with Hodgkin lymphoma (HL) depends on the responses to standard chemotherapy, radiotherapy, or combined therapy. Resource‐limited countries face numerous obstacles in supporting patients with HL who undergo chemotherapy, especially in advanced stages.AimTo analyze the survival outcomes of adult patients with HL after combined‐modality treatment (CMT) with involved‐field or non‐involved‐field radiotherapy.Methods and ResultsWe retrospectively reviewed the medical records of 90 adult patients with HL who received CMT at Rajavithi Hospital, Bangkok between 2007 and 2021. Patients with stage I‐IV disease received different therapies depending on their risk group. The risk groups were evaluated according to initial response, bulky disease, and B symptoms. Patients (n = 90) who underwent CMT were followed up for 34.7 months (range, 1–141 months). The median follow‐up periods of early and advanced‐stage patients were 53.1 months and 23.5 months, respectively. The estimated 5‐year overall survival (OS) and progression‐free survival (PFS) rates of patients with advanced‐stage diseases were 85% and 62%, respectively. There was a difference in the 3‐year overall survival among advance‐stage patients who underwent ABVD (94%) compared to those administered BEACOPPesc (50%), and the 3‐year PFS (84%) among patients who underwent ABVD was higher than that among those administered BEACOPPesc (66%). Radiotherapy increased toxicity but did not improve the survival rate.ConclusionChemotherapy administered to patients with advanced‐stage adult HL was more effective than BEACOPPesc when ABVD was administered. Our findings are relevant for hospitals with limited resources.
Principles of Self‐Repairing Ability of Tripodal Ligand‐Stabilized Hybrid Cobalt Hydroxide Nanosheets for Alkaline Water Electrolysis
Authors: Nakajima Ritsuki , Taniguchi Tatsuya , Sasaki Yuta , Nishiki Yoshinori , Awaludin Zaenal , Nakai Takaaki , Kato Akihiro , Mitsushima Shigenori , Kuroda Yoshiyuki 
Published: May 2023

AbstractSelf‐repairing catalysts are promising new materials for achieving long lifetime of alkaline water electrolyzers powered by renewable energy. Catalytic nanoparticles dispersed in an electrolyte were deposited on the anode to repair a catalyst layer by electrolysis. A hybrid cobalt hydroxide nanosheet modified with tris(hydroxymethyl)aminomethane on the surface (Co‐ns) was used as a catalyst. Assuming a pseudo‐first‐order process, the rate constant of an electrochemical deposition was linearly correlated with the electrode potential during electrolysis. Thus, it is expected that the repair of the catalyst is automatically controlled by changes in the oxygen evolution reaction (OER) overpotential. The essential step of the electrochemical deposition was the anodic oxidation of Co2+ to Co3+. Surface modification of Co‐ns protects Co2+ against the autooxidation of Co2+ caused by the dissolved oxygen. The redox properties and organic modification of Co‐ns make them well‐suited for the self‐repairing of anode catalysts.
Fe and Mo Co‐Modulated Coral‐like Nickel Pyrophosphate in situ Derived from Nickel‐Foam for Oxygen Evolution
Authors: Guo Wen , Yang Tao , Zhang Hongyan , Zhou Hao , He Maoshuai , Wei Wenxian , Liang Wenjie , Zhou Yilin , Yu Tingting , Zhao Hong 
Published: May 2023

AbstractA highly active catalyst for the oxygen evolution reaction (OER) is critical to achieve high efficiency in hydrogen generation from water splitting. Direct conversion of nickel foam (NF) into nickel‐based catalysts has attracted intensive interest due to the tight interaction of the catalysts to the substrate surface. However, the catalytic performances are still far below expectation because of the problems of low catalyst amount, thin catalyst layer, and small active area caused by the limitations of the synthesis method. Herein, we develop a Fe3+‐induced synthesis strategy to transform the NF surface into a thicker catalyst layer. In addition to the excellent conductivity and high stability, the as‐prepared FeMo‐Ni2P2O7/NF catalysts expose more active sites and facilitate mass transfer due to their thicker catalyst layer and highly dense coral‐like micro‐nano structure. Furthermore, the Mo, Fe co‐modulation optimizes the adsorption free energies of the OER intermediates, boosting catalytic activities. Its catalytic activity is among the highest, and it exhibits a small Tafel slope of 34.71 mV dec−1 and a low overpotential of 161 mV for delivering a current density of 100 mA cm−2 compared to reported Ni‐based catalysts. The present strategy can be further used in the design of other catalysts for energy storage and conversion.
Designing online teaching curriculum to optimise learning for all students in higher education
Authors: Sheridan Lynn , Gigliotti Amanda 
Published: May 2023

AbstractDisruptions to higher education teaching have raised significant concerns over the best curriculum design for teaching online and for the inclusion of all students. Universal design for learning (UDL) together with curriculum research models – taxonomy of significant learning and integrated curriculum design (ICD), provides a curriculum approach to optimising students' learning and building engagement with learning online. This paper outlines the redesign process and decisions made to improve the curriculum design in an online sociology course in teacher education. The goals of the redesign were to optimise all student learning, engagement and perceived satisfaction. Data collection included student responses (pre and post), course evaluation, analytics and reflections from an expert reviewer. Analysis was guided by the UDL curriculum design principles of engagement, representation and action/expression. Emerging from this research is the need to ensure that online learning redesign is user‐friendly and engaging, with multiple supported learning opportunities for the students. This redesign strengthens the quality of online learning, with learning becoming more meaningful and learning activities incorporating elements that are reflective, instructional and social. One interesting aspect that emerged was the importance of the partnership between the academic and the instructional designer in the redesign process.
Problem solving in the mathematics curriculum: From domain‐general strategies to domain‐specific tactics
Authors: Foster Colin 
Published: May 2023

AbstractProblem solving is widely regarded as a fundamental feature within the school mathematics curriculum. However, there is considerable disagreement over what exactly problem solving is, and if and how it can be taught. In this article, I define problems as non‐routine tasks and propose the explicit teaching of domain‐specific problem‐solving tactics that are applicable over narrow ranges of mathematical content. This is in contrast to the widespread practice of attempting to teach domain‐general strategies that are supposedly applicable across diverse content areas. The proposed approach here systematically introduces students to a well‐defined set of high‐leverage content‐specific tactics, presented in a purposeful order and taught explicitly through the use of carefully chosen problems which those tactics dramatically unlock. I argue that this sequenced approach to teaching problem‐solving addresses concerns widely reported about the apparent unteachability of domain‐general problem‐solving strategies and has the potential to enable all students to benefit from a powerful problem‐solving mathematics curriculum.
Non‐verbal behaviour of professional soccer players performing in the absence or presence of fans
Authors: Furley Philip , Riedl Nina , Lobinger Babett 
Published: May 2023

AbstractThe present research tested the impact of score line, spectator presence and game location on athletes’ non‐verbal behaviour (NVB). Two studies (N = 240; N = 160) tested whether the NVB of soccer players differed as a function of score line, spectator‐presence and game location by asking participants to guess the current score, the dominance, pride and confidence of soccer players in videos. Results demonstrated that NVB ratings were more negative when the athletes were trailing (less dominant, less proud, and less confident) compared to leading. Study 1 showed more non‐verbal expressiveness (social facilitation) of pleasant feelings (being in a high lead) and lower expressiveness (social inhibition) of negative feelings (trailing) in the presence of spectators. Study 2 indicated that leading at away games led to higher non‐verbal expressiveness, whereas leading at home games led to less non‐verbal expressiveness in the presence of a supportive audience.
Distinct invasive patterns in situ between estrogen receptor‐positive and triple‐negative breast cancer through the intraductal tracking of carbon nanoparticles
Authors: Kuang Xinwen , Luo Zixuan , Sun Zhihong , Hu Jiawei , Liu Jianhua , Kong Deguang , Wang Guannan , Guo Liantao , Luo Lan , Zheng Weijie , Sun Shengrong , Rao Yan , Chen Chuang 
Published: May 2023

AbstractGiven that the transition from ductal carcinoma in situ (DCIS) to invasive breast cancer (BC) is crucial during the BC progression, the mechanism involved in the invasion transition behind triple‐negative breast cancer (TNBC) and estrogen receptor‐positive (ER‐positive) subtype has remained elusive. This article detected distinct invasion patterns of BC cells between the ER‐positive and TNBC using intraductal murine models with intraductal administration of carbon nanoparticles (CNPs). First, the feasibility of the utility of CNPs as a tracer was proved. The area ratio of CNPs and tumor cells invading the stroma at the late stage was found significantly higher than that in the early stage in MNU‐induced ER‐positive BC. However, opposite results were obtained in the triple‐negative model. Consequently, we proposed that the ER‐positive phenotype cells behave differently between different stages during tumor progression while there is no such difference in the invasion process of TNBC cells. The analysis regarding the duct integrity along with immunohistochemical characteristics further explained the distinct invasion features between the ER‐positive and triple‐negative subtypes. Last, the relationship between the duct thickness and the duct integrity suggested that ER‐positive tumors gradually increased in size within the lumen before the invasion. Overall, this study suggested the different invasion characteristics of ER‐positive BC and TNBC in vivo.
Nature's Blueprint: Chelation‐Assisted C−H Functionalization for Selective and Efficient Reactions in Aqueous Media
Authors: Wang Yini , Zhang Xiandie , Zhang Jian , Zhong Guofu 
Published: May 2023

AbstractEfficient and sustainable strategies for C−H functionalization are crucial in organic synthesis. Bioinspired catalytic systems have emerged as promising alternatives to traditional synthetic methods. These systems draw inspiration from nature‘s ability to selectively functionalize complex molecules in water‐based environments. Among these, chelation‐assisted C−H functionalization stands out due to its ability to guide the substrate towards the active site of the catalyst, thereby controlling the selectivity of the reaction. This review focuses on the use of chelation assistance to enhance the efficiency and selectivity of bioinspired C−H functionalization reactions in aqueous media. We cover aliphatic, aromatic, and alkenyl C−H functionalization, as well as tandem C−H activation/cyclization, utilizing metallocycle intermediates. Additionally, we highlight the underlying mechanisms of these reactions for a deeper understanding and development of novel methodologies.
Facilitating caregiver‐child interactions in home visiting: A qualitative observational study
Authors: Huber Luke Timothy , Molthen Faith , Cook Gina , Hughes‐Belding Kere 
Published: May 2023

AbstractFacilitating parent‐child interactions is a key component of evidence‐based early childhood home visiting programs. Several observational measures have been created to effectively capture home visiting activities from an operationalized perspective. While the field has a reasonable understanding of what home visitors can do to facilitate developmentally supportive interactions, and why, the how remains elusive for many home visitors. This qualitative study used a modified grounded theory approach to examine the facilitation of caregiver‐child interactions during home visits. Home visit video recordings previously coded using the Home Visit Rating Scale (HOVRS) A+ were selected based on facilitation quality. Sixteen home visits (8 lower‐ and 8 higher‐quality facilitation scores) were examined for differences in home visitor behaviors that support parent‐child interactions during visits. We identified contextual and specific behaviors that home visitors used to actively engage caregivers and children together in developmentally supportive interactions. Results revealed 11 home visitor behaviors that discriminated higher quality facilitation. These behaviors were categorized into four domains: environmental conditions, executing the activity, strengths‐based focus, and caregiver responses. This qualitative study highlights specific behaviors and professional development areas to support more effective home visiting services for a diverse population of families with young children.
Disruption of neurosteroid synthesis and release by tris(2,3‐dibromopropyl)isocyanurate in primary mouse cortical astrocytes in vitro
Authors: Szychowski Konrad A. , Skóra Bartosz 
Published: May 2023

AbstractNeurosteroidogenesis in astrocytes is crucial for the proper development and functioning of the brain. During this process, key neurohormones such as progesterone (P4), testosterone (T), and estradiol (E2) are produced. Proper production and release of neurosteroids can be affected by substances referred to as endocrine‐disrupting compounds (EDCs). Tris‐(2,3‐dibromopropyl)isocyanurate (TBC) is a representative of novel brominated flame retardants used to stop ignition or reduce fire‐related property damage to plastics, polyolefin, polyphenyl alkene, unsaturated polyester, synthetic rubber, and fibers. Interestingly, previous studies have shown that TBC can enhance the proliferation of estradiol‐sensitive breast cancers in vitro, which suggests that TBC has EDC properties. Therefore, given the suspected endocrine‐disrupting properties of TBC, the aim of the present study was to determine the impact of TBC on the neurosteroid (P4, T, and E2) production and secretion as well as the mRNA expression of key enzymes involved in its production in mouse astrocytes in vitro. Our paper shows that TBC increases P4 production with a strong decrease in T production, which is accompanied by a decrease in Cyp17a1 mRNA expression, that is, the main enzyme metabolizing P4 to T. Moreover, TBC in both studied concentrations increases P4 secretion in the culture medium. Finally, our studies have demonstrated an increase in the expression of Cyp19a1 mRNA, an enzyme metabolizing T to E2, with a simultaneous increase in the amount of E2 in cells. Our data clearly show that TBC in an in vitro environment acts as EDCs, which may lead to serious consequences for the proper development and functioning of the brain.
Targeting extracellular vesicle delivery to the lungs by microgel encapsulation
Authors: Cober Nicholas D. , Rowe Katelynn , Deng Yupu , Benavente‐Babace Ainara , Courtman David W. , Godin Michel , Stewart Duncan J. 
Published: May 2023

AbstractExtracellular vesicles (EVs) secreted by stem and progenitor cells have significant potential as cell‐free ‘cellular’ therapeutics. Yet, small EVs (<200 nm) are rapidly cleared after systemic administration, mainly by the liver, presenting challenges targeting EVs to a specific organ or tissue. Microencapsulation using natural nano‐porous hydrogels (microgels) has been shown to enhance engraftment and increase the survival of transplanted cells. We sought to encapsulate EVs within microgels to target their delivery to the lung by virtue of their size‐based retention within the pulmonary microcirculation. Mesenchymal stromal cell (MSC) derived EVs were labelled with the lipophilic dye (DiR) and encapsulated within agarose‐gelatin microgels. Endothelial cells and bone marrow derived macrophages were able to take up EVs encapsulated in microgels in vitro, but less efficiently than the uptake of free EVs. Following intrajugular administration, microgel encapsulated EVs were selectively retained within the lungs for 72h, while free EVs were rapidly cleared by the liver. Furthermore, microgel‐loaded EVs demonstrated greater uptake by lung cells, in particular CD45+ immune cells, as assessed by flow cytometry compared to free EVs. Microencapsulation of EVs may be a novel tool for enhancing the targeted delivery of EVs for future therapeutic applications.
Mapping sparse signed graphs to (K2k,M) $({K}_{2k},M)$
Authors: Naserasr Reza , Škrekovski Riste , Wang Zhouningxin , Xu Rongxing 
Published: May 2023

AbstractA homomorphism of a signed graph to is a mapping of vertices and edges of to (respectively) vertices and edges of such that adjacencies, incidences, and the signs of closed walks are preserved. We observe in this work that, for , the ‐coloring problem of a given graph can be captured by homomorphism to from a signed bipartite graph that is built from . Here assigns a negative sign to the edges of a perfect matching and a positive sign to the rest. Motivated by these reformulations and in connection with results on 3‐colorings of planar graphs, such as Grötzsch's theorem, we prove that any signed graph with the maximum average degree strictly less than admits a homomorphism to . For , we show that the maximum average degree being strictly less than 3 would suffice for a signed graph to admit a homomorphism to . Both of these bounds are tight. We discuss applications of our work to signed planar graphs and its connection to the study of homomorphisms of 2‐edge‐colored graphs. Among a number of interesting questions that are left open, a notable one is a possible extension of Steinberg's conjecture for the class of signed bipartite planar graphs.
Deep brain stimulation and intrathecal/intraventricular baclofen for glutaric aciduria type 1: A scoping review, individual patient data analysis, and clinical trials review
Authors: Shlobin Nathan A. , Hofmann Katherine , Keating Robert F. , Oluigbo Chima O. 
Published: May 2023

AbstractGlutaric aciduria type 1 (GA1) is an autosomal recessive disease frequently leading to dystonia. Deep brain stimulation (DBS), intrathecal baclofen (ITB), and intraventricular baclofen (IVB) are the current interventional treatment options for refractory dystonia. We performed a scoping review, individual patient data (IPD) analysis, and clinical trials review to summarize the existing literature on these interventions in this population, characterize outcomes, and suggest directions for future investigation. PubMed, Embase, and Scopus were searched following PRISMA guidelines. IPD were extracted from studies providing IPD for GA1 patients. ClinicalTrials.gov was reviewed. Of 139 articles, 7 studies with 10 patients were included. In study‐level data, 2/4 (50.0%) DBS studies found no improvement in dystonia and 3/3 (100%) on baclofen found decreased dystonia and enteral medication regimen. In the IPD analysis, four studies with 5 patients (2 IVB, 2 DBS, 1 ITB) were included. The average percent reduction in dystonia was 29.9% ± 32.5% (median:18%, IQR:18%–29.2%). Function improved in 4 (80.0%) patients. All patients with reported changes in enteral dystonia‐related medication regimen (3/3, 100%) reported reduction in medication usage. No patients (0%) had perioperative complications. Mean follow‐up length was 14.8 ± 12.2 months. No interventional clinical trials were found. ITB, IVB, and DBS represent present neuromodulatory approaches for the treatment of GA1. ITB and IVB reduce dystonia, while DBS has a heterogeneous effect. ITB and IVB improved function and reduced enteral medication regimens. These findings must be viewed with caution considering limited data and a serious risk of bias. Further large‐scale studies are necessary to determine indications for ITB, IVB, and DBS and elucidate treatment algorithms.
25‐hydroxycholesterol inhibits human papillomavirus infection in cervical epithelial cells by perturbing cytoskeletal remodeling
Authors: Li Boning , Hua Chen , Tian Pu , Sha Yiou , Zhang Lu , Wang Qian , Lu Lu , Jiang Shibo , Sui Long 
Published: May 2023

AbstractPersistent high‐risk human papilloma virus (HR‐HPV) infection is the main risk factor for cervical cancer, threatening women's health. Despite growing prophylactic vaccination, annual cervical cancer cases are still increasing and show a trend of younger onset age. However, therapeutic approaches towards HPV infection are still limited. 25‐hydrocholesterol (25HC) has a wide‐spectrum inhibitory effect on a variety of viruses. To explore efficient interventions to restrict HPV infection at an early time, we applied different pseudoviruses (PsV) to evaluate anti‐HPV efficacy of 25HC. We tested PsV inhibition by 25HC in cervical epithelial‐derived HeLa and C‐33A cells, using high‐risk (HPV16, HPV18, HPV59), possibly carcinogenic (HPV73), and low‐risk (HPV6) HPV PsVs. Then we established murine genital HPV PsV infection models and applied IVIS to evaluate anti‐HPV efficacy of 25HC in vivo. Next, with the help of confocal imaging, we targeted 25HC activity at filopodia upon HPV exposure. After that, we used RNA‐seq and Western blot analysis to investigate (1) how 25HC disturbs actin cytoskeleton remodeling during HPV infection and (2) how prenylation regulates the cytoskeletal remodeling signaling pathway. Our findings suggest that 25HC perturbs F‐actin rearrangement by reducing small GTPase prenylation. In this way, the phenomenon of HPV virion surfing was restricted, leading to failed infection.