bluuebunny/crossref_metadata_2025_split huggingface dataset:
Widespread epistasis shapes RNA Polymerase II active site function and evolution
Authors: Duan Bingbing , Qiu Chenxi , Sze Sing-Hoi , Kaplan Craig 
Published: March 2023

ABSTRACTMulti-subunit RNA Polymerases (msRNAPs) are responsible for transcription in all kingdoms of life. These enzymes rely on dynamic, highly conserved active site domains such as the so-called “trigger loop” (TL) to accomplish steps in the transcription cycle. Mutations in the RNA polymerase II (Pol II) TL confer a spectrum of biochemical and genetic phenotypes that suggest two main classes, which decrease or increase catalysis or other nucleotide addition cycle (NAC) events. The Pol II active site relies on networks of residue interactions to function and mutations likely perturb these networks in ways that may alter mechanisms. We have undertaken a structural genetics approach to reveal residue interactions within and surrounding the Pol II TL – determining its “interaction landscape” – by deep mutational scanning inSaccharomyces cerevisiaePol II. This analysis reveals connections between TL residues and surrounding domains, demonstrating that TL function is tightly coupled to its specific enzyme context.
Rolosense: Mechanical detection of SARS-CoV-2 using a DNA-based motor
Authors: Piranej Selma , Zhang Luona , Bazrafshan Alisina , Marin Mariana , Melikyan Gregory B. , Salaita Khalid 
Published: March 2023

AbstractAssays detecting viral infections play a significant role in limiting the spread of diseases such as SARS-CoV-2. Here we present Rolosense, a virus sensing platform that transduces the motion of synthetic DNA-based motors transporting 5-micron particles on RNA fuel chips. Motors and chips are modified with virus-binding aptamers that lead to stalling of motion. Therefore, motors perform a “mechanical test” of viral target and stall in the presence of whole virions which represents a unique mechanism of transduction distinct from conventional assays. Rolosense can detect SARS-CoV-2 spiked in artificial saliva and exhaled breath condensate with a sensitivity of 103copies/mL and discriminates among other respiratory viruses. The assay is modular and amenable to multiplexing, as we demonstrated one-pot detection of influenza A and SARS-CoV-2. As a proof-of-concept, we show readout can be achieved using a smartphone camera in as little as 15 mins without any sample preparation steps. Taken together, mechanical detection using Rolosense can be broadly applied to any viral target and has the potential to enable rapid, low-cost, point-of-care screening of circulating viruses.
Impact of participation in the belt and road initiative on regional economic resilience at province level
Authors: Yang Wei , Lao Xiaoyun , Zhou Qing , Liu Jian 
Published: March 2023

Purpose
This study aims to examine how participation in the Belt and Road Initiative (BRI) affects province-level regional economic resilience. In the context of dual circulation – the new development paradigm proposed by the Chinese Government – participating in the BRI is an important means of connecting both international and domestic circulations and achieving high economic resilience. The complex causal relationship between participation in the BRI and province-level regional economic resilience is investigated.

Design/methodology/approach
Based on the complex system view, this study uses fuzzy set qualitative comparative analysis (fsQCA) to examine the impact on regional economic resilience when provinces participate in the BRI through unimpeded trade, infrastructure connectivity, financial integration and people-to-people bonds under the two conditions of attention allocation and buffering capacity. Qualitative textual analysis is applied to analyse provincial work reports, and relevant statistical data are used to measure the economic resilience from 2013 to 2020.

Findings
The authors identified three condition configurations that lead to a high regional economic resilience at province-level and one condition configuration that lead to no high-level regional economic resilience.

Research limitations/implications
In-depth analyses of qualitative materials should be conducted to explain the systematic relationships among the conditions.

Originality/value
This research is of practical significance to the development of the theoretical framework and practices of the BRI in the context of dual circulation.
A comparative study of the predictive power of component-based approaches to structural equation modeling
Authors: Cho Gyeongcheol , Kim Sunmee , Lee Jonathan , Hwang Heungsun , Sarstedt Marko , Ringle Christian M. 
Published: March 2023

Purpose
Generalized structured component analysis (GSCA) and partial least squares path modeling (PLSPM) are two key component-based approaches to structural equation modeling that facilitate the analysis of theoretically established models in terms of both explanation and prediction. This study aims to offer a comparative evaluation of GSCA and PLSPM in a predictive modeling framework.

Design/methodology/approach
A simulation study compares the predictive performance of GSCA and PLSPM under various simulation conditions and different prediction types of correctly specified and misspecified models.

Findings
The results suggest that GSCA with reflective composite indicators (GSCAR) is the most versatile approach. For observed prediction, which uses the component scores to generate prediction for the indicators, GSCAR performs slightly better than PLSPM with mode A. For operative prediction, which considers all parameter estimates to generate predictions, both methods perform equally well. GSCA with formative composite indicators and PLSPM with mode B generally lag behind the other methods.

Research limitations/implications
Future research may further assess the methods’ prediction precision, considering more experimental factors with a wider range of levels, including more extreme ones.

Practical implications
When prediction is the primary study aim, researchers should generally revert to GSCAR, considering its performance for observed and operative prediction together.

Originality/value
This research is the first to compare the relative efficacy of GSCA and PLSPM in terms of predictive power.
Measuring the research funding landscape: a case study of BRICS nations
Authors: Shueb Sheikh , Gul Sumeer 
Published: March 2023

Purpose
The purpose of this study is to determine the funding ratio of BRICS nations in various research areas. The leading funding institutions that support research in the developing world have also been researched.

Design/methodology/approach
This study involves the funding acknowledgment analysis of the data retrieved from the “Clarivate Analytics' InCites database” under “22 specific research areas” to determine whether the publication was funded.

Findings
This study shows that China achieves the highest funding ratio of 88.6%, followed by Brazil (73.74%), Russia (72.93%) and South Africa (70.94%). However, India has the lowest funding ratio of 58.2%. For the subject areas, the highest funding ratio is by microbiology in Russia (86.6%), India (84.3%) and China (96.9%) and space science in Brazil (93.7%) and South Africa (94.82%). However, economics and business achieves the lowest funding ratio in Brazil (38.6%), India (20.1%) and South Africa (30.24%). Moreover, the regional funding agencies are the leading research sponsors in the BRICS nations.

Practical implications
This study implies increasing the funding ratio across various research areas, including arts, humanities and social sciences. The nations, particularly India, also need to gear up sponsoring the research to improve the funding ratio for scientific development, bringing overall good.

Originality/value
This study efforts to show the status of countries and research subjects in terms of funding ratio and reveals the prominent funders working toward scientific growth.
Bank lending and macroprudential policies: are Islamic banks differentially affected?
Authors: Albinali Abdulla 
Published: March 2023

PurposeThe purpose of the paper is to study the relevance of macroprudential policies (MPPs) in influencing bank lending in small open economies with dual banking systems.Design/methodology/approachIn the analysis, the author employed the dynamic panel data methodology as compared to alternate techniques since it is able to address potential endogeneity challenges.FindingsUsing quarterly data from the period 2002–2020, the author finds that MPPs are highly effective in containing the growth of public credit, whereas its impact on private credit is much less effective. The disaggregated findings reveal that macroprudential measures are less effective in containing the growth of private credit by Islamic banks.Originality/valueThe majority of studies on MPPs are focused on emerging and advanced economies, limiting their policy appeal from the standpoint of small open economies. In this connection, this paper contributes to the literature on the relevance of such policies for a small open economy with a dual banking system and significant hydrocarbon exports. The paper's analysis therefore holds relevance for similar economies, both in the region and elsewhere, on the role and relevance of MPPs with emphasis on Islamic banks.
Error management orientation: impact on service recovery performance, and the mediating role of self-efficacy
Authors: Guchait Priyanko 
Published: March 2023

Purpose
This paper investigates whether error management orientation (EMO) of hospitality employees influence their service recovery performance (SRP) through self-efficacy.

Design/methodology/approach
In Study 1, data was collected from 161 hotel managers in the USA. In Study 2, data was collected from 215 restaurant employees in Turkey. Partial least squares (PLS) method using SmartPLS 3.3.3 was used for data analysis.

Findings
The results indicated that EMO of hospitality employees increases their self-efficacy beliefs which in turn enhance their SRP. The findings were consistent in both studies.

Practical implications
Hospitality organizations should consider assessing EMO of individuals when making selection decisions. These organizations should also consider providing error management training to employees to develop their EMO, improve error management skills and performance.

Originality/value
To the best of the author’s knowledge, this is the first study that focuses on EMO of hospitality managers and employees. Error orientation refers to how individuals cope with and how they think about errors at work. Errors are part of our work lives, and a positive orientation toward errors (i.e. EMO) can have a significant impact on individuals’ work attitudes, behaviors and performances. This is the first study that examines EMO as an important predictor of SRP. This study also makes a contribution by studying the mediating effect of self-efficacy to understand the underlying mechanism that links EMO with SRP.
This ad’s for you: how personalized SNS advertisements affect the consumer–brand relationship
Authors: Tran Trang , Sen Sandipan , Van Steenburg Eric 
Published: March 2023

Purpose
Firms can now access users’ digital histories due to advances in technology and deliver personalized recommendations through social network sites (SNS) such as Facebook that offers advanced targeting options and reliable conversion tracking. This paper aims to examine the effects of personalized advertisements on SNS on the relationship between consumers and brands, tests the impact of brand attachment and experience on brand equity through personalized SNS ads and investigates the influence of such ads on branded products and services.

Design/methodology/approach
Two studies were conducted. Study 1 (n = 275) was a survey-based design that leveraged structural equation modeling to test the hypotheses, while Study 2 (n = 350) used experimental design to compare two groups who saw service brand ads versus those who saw product brand ads.

Findings
Results showed that SNS ads supporting the brand had a significant positive impact on respondents’ brand attachment and brand experience. In both studies, brand experience positively impacted all the elements of brand equity, while brand attachment was found to impact brand loyalty.

Originality/value
The findings illustrate how personalized ads for brands appearing on SNS can change consumer perceptions, thus affecting the consumer–brand relationship. The results bode well for brands considering leveraging SNS in their marketing mix, particularly when the strategy behind the advertising is brand building.
Does happiness raise test scores – does fear lower them – experimental evidence
Authors: Noussair Charles N. , Seaback Kierstin 
Published: March 2023

PurposeThe authors consider whether the emotional states of happiness and fear causally affect test performance using a new experiment. The paper aims to discuss this issue.Design/methodology/approachHappiness and fear are induced with 360-degree videos shown in virtual reality before participants take a test consisting of mathematics scholastic aptitude tests (SAT) questions.FindingsThe results show that scores improve by 0.48 standard deviations under the happiness condition, and the effect is particularly large for women (0.75 s.d.). Inducing fear has no effect on test scores.Originality/valueThis is one of the first studies to employ virtual reality for emotion induction. It establishes that test scores can be improved by inducing an emotional state of happiness shortly before the test.
Anti-corrosive agents based benzil-thiocarbohydrazone macrocyclic ligand-derived Cu (II) and Zn (II) chelates: template synthesis and physically admixing with epoxy coating
Authors: Elgammal Walid E. , Eliwa Essam M. , Goomaa Hosni A. , Owda Medhat E. , Abd El-Wahab H. 
Published: March 2023

Purpose
This paper aims to focus on the synthesis of the macrocyclic complexes (Cu and Zn) and their applications as anticorrosive materials in epoxy paint formulation for surface coating application.

Design/methodology/approach
A selected macrocyclic Cu(II) and Zn(II) complexes were prepared via template synthesis and characterized using Fourier transform infrared, thermal gravimetric analysis, scanning electron microscope, flexibility, hardness and adhesion of coating films prepared using epoxy paint.

Findings
The corrosion resistance of the epoxy-painted films was improved due to the incorporation of the Zn and Cu complexes into the formulation.

Originality/value
It was found that the metal complex-based formulation with Cu(II) and Zn(II) had outperformed the sample blank.
Parents’ mental state communication and children’s consumer behavior in the USA
Authors: Choi Eunjoo , Lapierre Matthew A. 
Published: March 2023

Purpose
Previous research has shown that children’s ability to understand mental states is related to their consumer development, yet it is unknown how parents can aid in this process. One possible way that parents may help is using mental state communication (i.e. communication that focuses on beliefs/intention to explain behavior by others). This study aims to examine whether this kind of communication is linked to children’s purchase requests through two potential mediators – active mediation and child socio-cognitive skills (i.e. Theory of Mind).

Design/methodology/approach
This study used a survey of 420 American mothers with children between the ages of 3 and 7. Respondents were given 12 scenarios describing typical parent–child interactions focused on discussing mental states and were asked how they would respond. Then, respondents were asked about demographic information, parenting style, mediation style, child socio-cognitive skills and child purchase requests.

Findings
Results showed both a direct and indirect negative association between parents’ mental state communication and children’s purchase requests via active advertising mediation. Contrary to expectations, active mediation was negatively associated with mental state communication and positively linked to child purchase requests. Children’s socio-cognitive skills were not associated with either parents’ mental state communication or children’s purchase requests.

Originality/value
To the best of the authors’ knowledge, this is the first known study that has examined mental state communication of parents as a potential predictor in shaping children’s purchase requests and found that it was negatively associated with it.
Sensory descriptive analysis of hard ciders from the Northeast and Mid‐Atlantic United States
Authors: Calvert Martha D , Neill Clinton L , Stewart Amanda C. , Lahne Jacob 
Published: March 2023

AbstractAlthough alcoholic or “hard” cider is a beverage of growing popularity throughout the Northeastern and Mid‐Atlantic United States (US), the industry lacks a consistent language for describing the sensory quality of its products. The main objective of this research was to explore the sensory attributes that can be used to describe a large representative sample (N = 42 samples) of ciders from Virginia, Vermont, and New York, using classical descriptive analysis (DA). The secondary objective of the research was to determine if cider samples’ sensory attributes differ based on extrinsic factors, such as style, packaging, and apple varieties. The study was conducted using a standard DA: 8 panelists were trained for 13 h to develop a lexicon of aroma, taste, and mouthfeel descriptors for 42 cider samples (15 single varietal ciders, 27 blended ciders). Then, subjects evaluated each cider in duplicate for all descriptive attributes in standard sensory‐evaluation conditions. Results were analyzed to determine overall differences among the individual cider samples, geographic origins, cider styles, and packaging formats, as well as significant differences across individual attributes. Herein, we report on 29 attributes that can be used to discriminate cider samples, as well as a subset of attributes which differentiate ciders based on extrinsic product variables. These results provide a framework for describing ciders from the Northeast and Mid‐Atlantic regions of the US, which may be further generalizable to other North American ciders. As well, these results highlight the potential for more descriptive, sensory‐based style guidelines may inspire future research related to cider production practices and terroir.
Ion release from oral piercings from in vitro acidic challenges
Authors: Masood M , Walsh LJ , Zafar S 
Published: March 2023

ABSTRACTObjectivesThis laboratory‐based study measured ion release from metallic piercings when exposed to organic acids (lactic, citric) and inorganic acids (phosphoric, hydrochloric) that could be encountered in the oral cavity.MethodsBarbell and ring oral piercings composed of stainless steel, titanium or gold‐plated titanium were submerged in 2 mL volumes of 0.1% lactic acid, 10% citric acid, 0.2% phosphoric acid, and 0.1% hydrochloric acid for 7 and 34 days. Ion release into the liquid was measured using inductively coupled plasma optical emission spectroscopy (ICPOES) and expressed in relationship to surface area. Surface changes from baseline were assessed using light and backscatter scanning electron microscopy (SEM).ResultsICPOES results showed that hydrochloric and phosphoric acid caused the greatest release of material per surface area. Released elements included (ranked highest to lowest): Fe, P, Ti, Na, Cr, S, Ni, Ca, Mg, K, Si, Al, V, Mn, Ba, and Co. SEM imaging identified qualitative surface changes consistent with corrosion, for most piercing types examined.ConclusionsUnder the exposure conditions used, inorganic acids cause greater metal dissolution than organic acids. Inorganic acids could therefore pose a risk of corrosion and leaching of ions from metallic oral piercings.
Bureaucratising Social Justice: The reproduction of social inequality through scholarship programs in Nepal
Authors: Pradhan Uma , Wallenius Todd John , Valentin Karen 
Published: March 2023

AbstractThis article draws on ethnographic data on the distribution of scholarship programs at two Nepali state‐run schools. Anchored in the cross‐field of educational anthropology and the anthropology of bureaucracy, this article examines schools not just as sites of learning but as institutions that control and regulate access through bureaucratized mechanisms. We draw attention to scholarship processes as inherently selective and requiring social and cultural capital, thus leading to what we term “the bureaucratization of social justice.”
A novel nonsense variant in the ATL3 gene is associated with disturbed pain sensitivity, numbness of distal limbs and muscle weakness
Authors: Mohammadi Sanaz , Jafari Khamirani Hossein , Baneshi Maryam , Kamal Neda , Manoocheri Jamal , Saffar Mahsa , Dianatpour Mehdi , Tabei Seyed Mohammad Bagher , Dastgheib Seyed Alireza 
Published: March 2023

AbstractIntroductionHereditary sensory neuropathy (HSN) describes as a heterogeneous group of peripheral neuropathies. HSN type 1 (HSN1) is one subtype characterized by distal sensory impairment that occurs in the form of numbness, tingling, or pain. To date, only two variants in the atlastin GTPase 3 (ATL3) gene have been identified that result in hereditary sensory neuropathy type 1F (HSN1F) with autosomal dominantinheritance.MethodsWe sudied and examined who present with sensory disturbances and muscle weakness in their lower limb. Patients underwent Whole Exome Sequencing and Sanger sequencing was performed in families for validation of detected variant.ResultsHere, we identified two Iranian families carrying the novel heterozygous stop variant NM_015459.5: c.16C>T, p.Arg6Ter in ATL3 that led to disturbed pain and touch sensitivity. This variant in the ATL3 gene was detected in both families (NM_015459.5: c.16C>T, p.Arg6Ter) by whole‐exome sequencing and confirmed by Sanger sequencing.ConclusionIn this study, the subjects manifested weakness of distal limb muscles and numbness of the lower extremities. In addition, some unusual features, including hearing problems and inability to sit and walk presented in one of the patients. Eventually, we provide a case‐based review of the clinical features associated with HSN1F. Hitherto, only 11 patients with HSN1F have been reported. We compared our findings to previously reported cases, suggesting that the clinical features are generally variable in the HSN1F patients.
Use of implantable cardioverter‐defibrillator in children supported with ventricular assist device: An analysis of data from the EUROMACS registry
Authors: Schweiger Martin , Amodeo Antonio , Vierecke Juliane , Hussein Hina , Berger Florian , de By Theo M. M. H. , Zimpfer Daniel , Sliwka Joanna , Davies Ben , Miera Oliver , Meyns Bart 
Published: March 2023

AbstractBackgroundData on the use and outcome of children on ventricular assist device (VAD) support provided with an implantable cardioverter‐defibrillator (ICD) remains poor.MethodsA retrospective analysis of the EUROMACS database on children supported with VAD < 19 years of age from January 1, 2009 to April 1, 2020. Patients with missing data on status of ICD, missing baseline and/or follow up information were excluded. The primary independent variable of interest was the concomitant presence or absence of an ICD at the time of VAD placement. Kaplan–Meier survival analysis was performed to evaluate survival differences between children on VAD with and without an ICD.ResultsOut of 303 patients provided with a VAD, 7% (7♀, 15♂) had an ICD implanted and formed the study group. Median age was 14 years, median weight was 43.5 kg, and median BSA was 1.39. Median Intermacs stage was 2 (range: 1–7). Seventeen patients (77%) were transplanted, 4 (18%) died while on support, and 1 (5%) was weaned from device after myocardial recovery. Median time on support was 68 days compared to 361 days in the control group (p: 0.01). Three patients underwent device exchange due to thrombus formation in the pump. There was no difference in survival between groups (p = 0.342).ConclusionThe presence of ICD in pediatric patients supported with a VAD is low (7%). Children on VAD support provided with an ICD do not have a survival benefit compared to children without an ICD.