bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biphasic oxygen tension promotes the formation of transferable blastocysts in patients without euploid embryos in previous monophasic oxygen cycles
Authors: Chen Hsiu-Hui , Lee Chun-I , Huang Chun-Chia , Cheng En-Hui , Lee Tsung-Hsien , Lin Pin Yao , Chen Chien-Hong , Lee Maw-Sheng 
Published: January 2023

Abstract
This study evaluated whether the concentration of biphasic O2 (5–2%) promotes the formation of qualified blastocysts (QBs) and euploid blastocysts and increases the probability of cycles with transferable blastocysts. Total 90 patients (180 cycles) without euploid blastocysts in previous monophasic O2 (5%) cycles were enrolled for an additional cycle of biphasic O2 (5–2%). In the biphasic O2 (5–2%) tension group, the rate of QB (35.8%, 225/628) were significantly higher than those in the monophasic O2 (5%) group ( 23.5%, 137/582; p < 0.001). In addition, the number of euploid blastocysts (0.5 ± 0.8) and the percentage of cycles with transferable blastocysts were significantly higher in the biphasic O2 (5–2%) group (57.8%, 52/90) than in the monophasic O2 (5%) group (0 and 35.6%, 32/90, respectively; p = 0.003). Multivariable regression analysis also indicated that the QB rate and the probability of cycles with transferable blastocysts correlated with O2 tension (OR: 1.535, 95% CI: 1.325–1.777, and OR: 3.191, 95% CI: 1.638–5.679, respectively; p < 0.001). Biphasic O2 culture can be used as an alternative strategy to increase the number of euploid QBs and the probability of cycles with transferable blastocysts in patients with a poor prognosis.
Long-term outcomes after enterostomy for very early-onset inflammatory bowel disease with interleukin-10 signaling deficiency
Authors: Tang Zifei , Sun Song , Ji Min , Shi Peng , Wang Yuhuan , Huang Zhiheng , Huang Ying 
Published: January 2023

Abstract
Background: Very early-onset inflammatory bowel disease (VEOIBD) with interleukin-10 (IL10R) signaling deficiency usually requires enterostomy in patients who are refractory to traditional treatment. This study aimed to evaluate long-term outcomes after enterostomy for VEOIBD patients with IL10R signaling deficiency.
Methods: The medical records of all patients undergoing enterostomy for signaling deficiency were retrospectively assessed during 2012.1–2022.7 in a tertiary teaching hospital, Children’s Hospital of Fudan University, Shanghai, China. Data on disease history, diagnosis and detailsof enterostomy and stoma closure and follow-up were collected. Univariate and multivariate logistic regression analyses were used to evaluate the risk factors associated with the long-term outcome of delayed stoma closure.
Results: A total of 46 patients underwent an enterostomy, and these patients included 19 patients who required emergency enterostomy and 27 patients who required a selective enterostomy. After ten years of follow-up, 35 patients underwent hematopoietic stem cell transplantation(HSCT), and 25 patients were alive after HSCT. The median timeframe between HSCT and stoma closure was 19.6 [15.9,26.2] months. Nineteen patients underwent stoma closure and had an average age of3.9±1.5 years, and 6 patients were waiting for stoma closure. The multivariate logistic regression analysis showed that age atHSCT was an independent predictor of a shorter time to stoma (OR 1.09; 95% CI 0.99-1.19; p = 0.06). We also found a tendency difference in multiple intestinal lesions for the time of stoma closure (OR 3.22; 95% CI 0.37-27.77; p = 0.29).
Conclusions: This study determined the long-term outcomes after enterostomy for VEOIBD with interleukin-10 signaling deficiency. Early HSCT may facilitate shorter stoma closure times.
Retrospective observatory comparison of lumbar interbody fusion with pedicle screw fixation and cortical screw fixation for clinical outcome, including sagittal balance, in geriatric patients over 80 years old: a single-center, one-decade experience
Authors: Jang Giwuk , Lee Sanghoon , Park Jeongyoon , Ryu Seungjun , Zhang Hoyeol 
Published: January 2023

Abstract
Background

We aimed to retrospectively analyze the clinical and surgical outcomes following posterior lumbar interbody fusion plus pedicle screw fixation compared to midline lumbar fusion in patients aged ≥ 80 years with degenerative lumbar spine disease.

Methods

The study group comprised 68 patients aged ≥ 80 who underwent degenerative lumbar spinal surgery at our spine center between January 2011 and December 2020. Among them, 24 underwent posterior lumbar interbody fusion plus pedicle screw fixation, and the remaining 44 underwent midline lumbar fusion.

Results

No significant intergroup differences were found in age, sex ratio, follow-up duration, or surgical level. The Visual Analog Scale for lower back pain was significantly different between the two groups at 7 days after surgery (P = 0.049). The Oswestry Disability Index was significantly different between the two groups at 7 days after surgery (P = 0.05). The estimated blood loss and operative time differed significantly (P < 0.05). There was a statistically significant difference in the postoperative morbidities between the groups (P = 0.049).

Conclusions

Although the clinical outcomes were not significantly different between the two groups, the perioperative morbidity was better in the midline lumbar fusion group. Therefore, we conclude that midline lumbar fusion is not inferior to posterior lumbar interbody fusion plus pedicle screw fixation if there is a need for fusion in elderly patients over octogenarian.

Trial registration

The Institutional Review Board of National Health Insurance Service Ilsan Hospital approved this study (2022-01-027), and the requirement of informed consent was waived due to the study's retrospective nature.
Design and Introducing Quaternary Ammonium Hydroxide-Functionalized Graphene Oxide Quantum Dots as an Efficient Pseudo-Homogeneous Catalyst for Epoxidation of α,β-Unsaturated Ketones
Authors: Mohammed Mohammed Salim , Targhan Homa , Bahrami Kiumars 
Published: January 2023

Abstract
In present work, design and synthesis of a novel pseudo-homogeneous catalyst is described. For this purpose, amine-functionalized graphene oxide quantum dots (N-GOQDs) were prepared from graphene oxide (GO) by a facile one-step oxidative fragmentation approach. The prepared N-GOQDs were then decorated with quaternary ammonium hydroxide groups. Various characterization techniques clearly revealed that the quaternary ammonium hydroxide‐functionalized GOQDs (N-GOQDs/OH) have been successfully synthesized. TEM image revealed that the GOQDs particles are almost regularly spherical in shape and mono-dispersed with particle sizes <10 nm. The utility of the catalyst demonstrated toward epoxidation of α,β-unsaturated ketones in the presence of aqueous H2O2 as an oxidant at room temperature. The corresponding epoxide products were obtained in good to high yields. These procedure has the advantages of a green oxidant, high yields, involvement of non-toxic reagents and reusability of the catalyst without discernible loss in activity.
Evaluation of Learning in Remote Teaching using Digital Radiographic Image Database by Dental Students
Authors: Ferreira Joanna Rodrigues da Silva , Medeiros Mércia Lamenha , Dermeval Diego 
Published: January 2023

Abstract
The digital periapical radiographic image database was developed, implemented, and evaluated in association with PBL as an online teaching-learning strategy in the subject of Dental Radiology and Imaging. This qualitative-quantitative case study used an e-learning tool in six stages: pre-test and post-test; dialogical presentation; asynchronous study session; feedback and evaluation of reaction and motivation (Attention, Relevance, Confidence, and Satisfaction - ARCS). The analysis by triangulation of methods revealed that with significance, cognitive performance improved by 41.6\% between pre and post-tests. As for the motivational scale, 100\% of the students agreed that the activity was interesting, and the narratives expressed enthusiasm. There were divergences in the answers in the attention and confidence domains, signaling aspects that could be improved in the teaching-learning strategy. The application of e-learning facilitated the understanding of radiographic interpretation, making using these tools a promising approach.
Validation of novel catechol derivatives as potent Escherichia coli MetAP inhibitors using Molecular Docking and Molecular Dynamics Simulation
Authors: Chowdhury Abhishek , Laskar Monjur Ahmed , Panda Debashis , Choudhury Manabendra Dutta 
Published: January 2023

Abstract
Urinary tract infections (UTIs) are the most common form of nosocomial infection primarily caused by Escherichia coli. Complicated UTIs carries higher risk of treatment failure, recurrent infections and increased morbidity. Methionine aminopeptidase (MetAP) has got tremendous importance as bacterial drug target due to its role in cell growth and membrane integrity. However, participation of metal chelating residues and occurrence of the enzyme in human body complicates the process of selection of suitable inhibitor. This necessitates search of novel inhibitors with more interaction with active site residues as the MetAP has highly conserved active site residues. In this study, novel catechol derivatives were generated virtually and performed computational studies to find the best group of molecules with more stable binding.
The mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorder
Authors: Zhong Jing , Huang Xiao-Jie , Wang Xue-Mei , Xu Ming-Zhi 
Published: January 2023

Abstract
Background

Despite widespread acknowledgment of the impact of stressful life events on suicide risk, the understanding of the psychological mechanisms underlying the relationship between stressful life events and suicide risk in major depressive disorder (MDD) remain unclear. This study aim to examine whether the distress tolerance mediates the relationship between the stressful life events and suicide risk in patients with MDD.

Methods

A cross-sectional study was carried out among 125 Chinese patients with MDD, mean age was 27.05 (SD = 0.68) and 68.8% was females. The 17-item Hamilton Depression Rating scale (HAMD-17), the validated Chinese version of the Mini International Neuropsychiatric Interview (MINI) suicide module, Life Events Scale (LES) and Distress Tolerance Scale (DTS) were utilized to evaluate patient’s depressive symptoms, stressful life events, levels of distress tolerance, and suicide risk, respectively. Mediation analyses was used to test the mediation effect of distress tolerance on the relationship between stressful life events and suicide risk.

Results

75.2% patients with MDD had suicide risk. Pearson correlation analysis showed that stressful life events was positively correlated with suicide risk(r = 0.182, p<0.05). Stressful life events(r=-0.323, p<0.01) and suicide risk(r=-0.354, p<0.01) were negatively correlated with distress tolerance. Mediation analyses showed that the direct path from stressful life events to suicide risk was not significant (B = 0.012, 95% confidence interval (CI) [-0.017, 0.042]). Stressful life events can affect suicide risk indirectly through distress tolerance (B = 0.018, 95% CI [0.007, 0.031]), and the mediating effect accounts for 60.0% of the total effect.

Conclusion

Distress tolerance completely plays a mediating role between stressful life events and suicide risk. Further suicide prevention and intervention strategies should focus on increasing levels of distress tolerance in patients with MDD.
Self-reported quantity and quality of sleep in children and adolescents with a chronic condition compared to healthy controls
Authors: Biemans Drs. Camille F.M. , Nijhof Sanne L. , Gorter Prof. Dr. Jan Willem , Stevens Gonneke J.W.M. , de Putte Prof. Dr. Elise van , Hoefnagels Johanna W. , Berg Anemone van den , Ent Prof. Dr. Cornelis K. van der , Dudink Jeroen , Verschuren Olaf W. 
Published: January 2023

Abstract
Purpose
To assess self-reported quantity and quality of sleep in Dutch children with a chronic condition compared to healthy controls, compared to the recommended hours of sleep for youth.
Methods
Sleep quantity and quality were analyzed in children with a chronic condition (cystic fibrosis, chronic kidney disease, congenital heart disease, (auto-)immune disease, and medically unexplained symptoms (MUS); N = 291; 15 ± 3.1 years, 63.1% female. A subset of 171 children with a chronic condition were matched to healthy controls using Propensity Score matching, based on age and sex, ratio 1:4. Self-reported sleep quantity and quality were assessed with established questionnaires. Children with MUS were analyzed separately to distinguish between chronic conditions with and without an identified pathophysiological cause.
Results
Generally, children with a chronic condition met the recommended amount of sleep, however 22.3% reported poor sleep quality. No significant differences in sleep quantity and quality were found between the diagnosis groups. Children with a chronic condition and with MUS slept significantly more than healthy controls at ages 13, 15, and 16. Both at primary and secondary school, poor sleep quality was least frequent reported in children with a chronic condition and most often reported in children with MUS.
Conclusions
Overall, children with chronic conditions, including MUS, met the recommended hours of sleep for youth, and slept more than healthy controls. However, it is important to obtain a better understanding of why a substantial subset of children with chronic conditions, mostly children with MUS, still perceived their sleep quality as poor.
Working Women and Eldercare: A Qualitative Perspective
Authors: Govil Dipti , Sahoo Harihar , Chowdhury Biswabandita , James K.S. 
Published: January 2023

Abstract
Background
This paper aims to explore the elder caregiving process, the challenges faced by working women care providers, and the coping strategies adopted by them.
Methods
In-depth interviews with 48 participants from 25 multi-generational households were conducted in the slums of Mumbai and analysed using QSR-NVivo-10.
Results
A majority of the elderly had difficulty in mobility, were financially dependent on children, and had no social security. Working women caregivers supported the needs of the dependent elderly along with performing household chores and doing paid work. Though caregiving overstrained the care providers, strong family ties, acknowledgement of the contributions of the elderly during their young days, and the desire to set a precedent for the young generation did not let them step back from their duties. Sometimes, physically exhausted care providers unknowingly resorted to elderly abuse and neglect. At the same time, a bidirectional flow of support also existed. The expenditure on regular medication put families into financial distress, forcing women care providers to work to meet the needs of the family.
Conclusion
Conversations among generations helped a lot in enhancing family ties and reducing conflicts.
Prediction Model of Lung Adenocarcinoma Sorafenib Response Based on Random Forest
Authors: ding zhexin , Fei Dongying , Guo Lei 
Published: January 2023

Abstract
Background
Only some of the patients who were treated with sorafenib derive benefit, and they usually developed drug resistance around 6 months. This study aims to establish a response model of sorafenib to predict the sensitivity of lung adenocarcinoma cells.
Methods
In this study, gene expression data and sorafenib drug response data about 62 lung adenocarcinoma cell lines were analyzed from GDSC database. Random Forest algorithm was used to construct the model. GO, KEGG, and Reactome enrichment analysis was performed for the important genes in the model to explore the biological pathways involved by these genes, and constructed the gene set of sorafenib drug response related genes. Umap was used for nonlinear dimensional reduction of transcriptome data. Survival analysis was used to evaluate variable prediction ability. The predictive capabilities of a variable was summarized by the area under the curve (AUC).
Results
We obtained a Random Forest regression model and a gene set related to sorafenib response. The drug response genes were differentially expressed in sensitive cells and tolerant cells, and these genes were generally concentrated in mTOR, mitochondrial translation, redox metabolism and other important pathways. Ferroptosis and mitochondrial related reactions may play an important role in sorafenib response. In addition, in the TCGA database, we also found that the enrichment score of this gene set was significantly related to the prognosis of patients: A higher enrichment score of the gene set would lead to a worse prognosis and a lower score would show a better prognosis. Finally, area under the curve showed that this gene set can also be used to predict the prognosis of patients with lung adenocarcinoma.
Conclusion
In conclusion, we established a Random Forest model to predict cell resistance to sorafenib, and found a gene set related to sorafenib resistance. The gene set can predict the prognosis of patients with lung adenocarcinoma.
A Geochemical and Mineralogical Characterization of Soils Associated with Podoconiosis
Authors: Cooper Jamey N. , Nick Kevin E. 
Published: January 2023

Abstract
Podoconiosis is a disease that causes swelling and disfiguration of the lower legs that can be found in several developing countries where shoes are not regularly worn. The current model for the etiology of the disease proposes that mineralogical agents enter the lymph system through the skin leading to inflammation that causes swelling of the feet and legs. We collected 125 soil samples from 21 towns known to be associated with podoconiosis, 8 towns cited as unassociated with Podoconiosis as controls, and 3 towns of unknown status. Data collected for each soil sample included color, particle size, mineralogy, and geochemistry to distinguish unique components within the podoconiosis-associated soils. Our results indicate that podoconiosis-associated soils are more highly weathered than non-podoconiosis associated soils. The enrichment of kaolinite and gibbsite suggests that these minerals, their surface chemistry, and trace elements associated with them should be prioritized in future podoconiosis research. In addition, we found that color may be a valuable tool to identify soils that are of greater risk for inducing podoconiosis.
Sophorolipid inhibits histamine-induced itch by decreasing PLC/IP3R signaling pathway activation and modulating TRPV1 activity
Authors: Xu Rui-Qi , Ma Ling , Chen Timson , Zhang Wei-Xiong , Chang Kuan , Wang Jing 
Published: January 2023

Abstract
Biosurfactants are attracting much interest due to their potential application as therapeutic agents in the medical field. Previous studies have demonstrated that biosurfactant such as sophorolipid (SL) exhibits immunomodulatory effects. In this paper, we found the potential of sophorolipid for inhibiting histamine-induced itch and preliminarily explored its molecular basis. First, behavioral tests indicated that SL could remit the histamine-induced scratching behaviors of mice. Second, SL could suppress the the calcium influx induced by histamine, HTMT and VUF8430 in HaCaT cells. RT-PCR analysis showed that the histamine-induced upregulation of mRNA levels of phospholipase Cγ1 (PLCγ1), 1,4,5-trisphosphate receptor (IP3R), and protein kinase Cα (PKCα) could be inhibted by SL, suggesting that SL may impede the PLC-IP3R signaling pathway activated by histamine. In further tests, the capsaicin-induced calcium influx could also be inhibited by SL, and molecular docking analysis indicated the possible binding of SL with transient receptor potential vanilloid-1 (TRPV1). In summary, these results revealed that SL may inhibit histamine-induced itch by decreasing PLC/IP3R signaling pathway activation and modulating TRPV1 activity. This paper indicates that SL may be a useful treatment medicine for histamine-dependent itch.
On Design, Cost and Reliability Analysis of a Fault-Tolerant Multistage Interconnection Network Layout with Six Disjoint Paths
Authors: Sharma Vipin , Ansari Abdul Q. , Mishra Rajesh , Khanna Gaurav 
Published: January 2023

Abstract
Multistage interconnection networks (MINs) provide an efficient solution for communication between one or more processors and memory modules. These networks are suitable for computationally extensive applications. Although there exist a wide variety of fault-tolerant MIN designs, however there is always a scope of improvement in the design of MINs, which comes with challenges and trade-offs. More specifically there is always a need for fault-tolerant, reliable, and cost-effective designs of MINs, which can tolerate multiple switches and link failures. This always motivates a researcher to focus on various design options and architectural models to enhance performance of the MINs.Designing fault-tolerant MINs requires more disjoint paths from each source–destination (S-D) node pair capability to use all available paths effectively. This paper proposes a new MIN layout viz; 6DP-MIN, which provides six disjoint paths and 14/12 redundant paths for different S-D node pairs. This proposed 6DP-MIN is a modification of gamma interconnection network ( GIN). Performance of the proposed design layout (6-Disjoint Path MIN) has been evaluated in terms of fault-tolerance capability, all available paths, reliability (two-terminal, broadcast, and network), and cost per unit. The results have been compared with other variants of GINs such as SEGIN, SEGLNIN, 3-Disjoint gamma interconnection network, 3- disjoint path multistage interconnection networks, and 4-DGINs. The results suggests that the proposed 6DP-MIN is highly fault-tolerant and reliable with regards to other MINs used for comparison.
A Regularized Limited Memory Subspace Minimization Conjugate Gradient Method for Unconstrained Optimization
Authors: Sun Wumei , Liu Hongwei , Liu Zexian 
Published: January 2023

Abstract
In this paper, based on the limited memory techniques and subspace minimization conjugate gradient (SMCG) methods, a regularized limited memory subspace minimization conjugate gradient method is proposed, which contains two types of iterations. In SMCG iteration, we obtain the search direction by minimizing the approximate quadratic model or approximate regularization model. In RQN iteration, combined with regularization technique and BFGS method, a modified regularized quasi-Newton method is used in the subspace to improve the orthogonality. Moreover, some simple acceleration criteria and an improved tactic for selecting the initial stepsize to enhance the efficiency of the algorithm are designed. Additionally, an generalized nonmonotone line search is utilized and the global convergence of our proposed algorithm is established under mild conditions. Finally, numerical results show that, the proposed algorithm has a significant improvement over ASMCG_PR and is superior to the particularly well-known limited memory conjugate gradient software packages CG_DESCENT (6.8) and CGOPT(2.0) for the CUTEr library.
Mathematics Subject Classification (2000) 49M37 . 65K05 . 90C30