bluuebunny/crossref_metadata_2025_split huggingface dataset:
A posteriori error analysis of space-time discontinuous Galerkin methods for the ε-stochastic Allen–Cahn equation
Authors: Antonopoulou Dimitra C , Egwu Bernard , Yan Yubin 
Published: August 2023

Abstract
In this work, we apply an a posteriori error analysis for the space-time, discontinuous in time, Galerkin scheme, which has been proposed in Antonopoulou (2020, Space-time discontinuous Galerkin methods for the $\varepsilon $-dependent stochastic Allen–Cahn equation with mild noise. IMA J. Num. Analysis, 40, 2076–2105) for the $\varepsilon $-dependent stochastic Allen–Cahn equation with mild noise $\dot{W}^\varepsilon $ tending to rough as $\varepsilon \rightarrow 0$. Our results are derived under low regularity since the noise even smooth in space is assumed only one-time continuously differentiable in time, according to the minimum regularity properties of Funaki (1999, Singular limit for stochastic reaction–diffusion equation and generation of random interfaces. Acta Math. Sinica, 15, 407–438). We prove a posteriori error estimates for the $m$-dimensional problem, $m\leq 4$ for a general class of space-time finite element spaces. The a posteriori bound is growing only polynomially in $\varepsilon ^{-1}$ if the step length $h$ is bounded by a positive power of $\varepsilon $. This agrees with the restriction posed so far in the a priori error analysis of continuous finite element schemes for the $\varepsilon $-dependent deterministic Allen–Cahn or deterministic and stochastic Cahn–Hilliard equation. As an application, we examine tensorial elements where the discrete solution is approximated by polynomial functions of separated space and time variables; the a posteriori estimates there involve dimensions, and the space, time discretization parameters. We then consider the special case of the mild noise $\dot{W}^\varepsilon $ as defined in Weber (2010, On the short time asymptotic of the stochastic Allen–Cahn equation. Ann. Inst. Henri Poincare Probab. Stat., 46, 965–975) through the convolution of a Gaussian process with a proper mollifying kernel, which is then numerically constructed. Finally, we provide some useful insights for the numerical algorithm, and present for the first time some numerical experiments of the scheme for both one- and two-dimensional problems in various cases of interest, and compare with the deterministic ones.
Manufacturing Processes of a Purified Microbiome Therapeutic Reduce Risk of Transmission of Potential Bacterial Pathogens in Donor Stool
Authors: McChalicher Christopher W J , Lombardo Mary-Jane , Khanna Sahil , McKenzie Gregory J , Halvorsen Elizabeth M , Almomani Sanabel , Schuster Brian , Hasson Brooke R , McGovern Barbara H , Ege David S , Auniņš John G 
Published: August 2023

Abstract

Background
Although fecal microbiota transplant has been used to prevent recurrent Clostridioides difficile infection (rCDI), documented pathogen transmissions highlight inherent safety risks of minimally processed stool. We describe manufacturing processes for fecal microbiota spores, live (VOWST; VOS, formerly SER-109), a microbiota-based oral therapeutic of Firmicutes spores.

Methods
Bacterial inactivation kill curves were obtained after ethanol exposure for 4 model organisms spiked into process intermediates.

Results
Bacterial log reduction factors ranged from 6.5 log10 to 7.4 log10 and lysis of spiked organisms occurred rapidly within 30 seconds.

Conclusions
These experiments demonstrate substantial and rapid inactivation of representative organisms, supporting the potential benefit of VOS manufacturing processes to mitigate risk.
Natural Resource Exploitation and Military Spending
Authors: Conrad Justin 
Published: August 2023

Abstract
Why do some states allocate more resources to their military than others? Governments are likely to perceive acute threats to their authority and legitimacy when they face insurgencies in which rebel groups earn significant revenues from the exploitation of natural resources. In response, governments allocate greater amounts to their military budgets. Using data on the exploitation of natural resources by rebel groups and defense spending for states around the world, I find that states where rebel groups profit from natural resources allocate more to their defense budgets than other states. This finding holds even after controlling for the presence of civil conflict itself. The study suggests that rebel exploitation of resources may have an indirect impact on interstate relations: If states indeed face a security dilemma, then increased spending resulting from these internal dynamics is likely to exacerbate the problem.
Yeasts as sustainable biocontrol agents against ochratoxigenic Aspergillus species and in vitro optimization of ochratoxin A detoxification
Authors: Cardoso Gimenes Danielle , Ono Mario Augusto , de Souza Suguiura Igor Massahiro , Macagnan Rafaela , Sartori Daniele , Borsato Dionisio , Pelegrinelli Fungaro Maria Helena , Ono Elisabete Yurie Sataque 
Published: August 2023

Abstract

Aims
The aims of this study were to evaluate the potential of Hanseniaspora opuntiae, Meyerozyma caribbica, and Kluyveromyces marxianus for in vitro biocontrol of Aspergillus ochraceus, A. westerdijkiae, and A. carbonarius growth, the ochratoxin A (OTA) effect on yeast growth, and yeast in vitro OTA detoxification ability using an experimental design to predict the combined effects of inoculum size, incubation time, and OTA concentration.

Methods and Results
Predictive models were developed using an incomplete Box–Behnken experimental design to predict the combined effects of inoculum size, incubation time, and OTA concentration on OTA detoxification by the yeasts. The yeasts were able to inhibit fungal growth from 13% to 86%. Kluyveromyces marxianus was the most efficient in inhibiting the three Aspergillus species. Furthermore, high OTA levels (100 ng ml−1) did not affect yeast growth over 72 h incubation. The models showed that the maximum OTA detoxification under optimum conditions was 86.8% (H. opuntiae), 79.3% (M. caribbica), and 73.7% (K. marxianus), with no significant difference (P &gt; 0.05) between the values predicted and the results obtained experimentally.

Conclusion
The yeasts showed potential for biocontrol of ochratoxigenic fungi and OTA detoxification, and the models developed are important tools for predicting the best conditions for the application of these yeasts as detoxification agents.
The effects of dietary essential fatty acid ratios and linoleic acid level in grow–finish pigs
Authors: Becker Spenser L , Humphrey Dalton C , Karriker Locke A , Brown Justin T , Skoland Kristin J , Greiner Laura L 
Published: August 2023

Abstract
The objective of this study was to investigate the effects of dietary linoleic acid level and the ratio of linoleic acid:linolenic acid (LA:ALA) on the growth performance, expression of genes associated with lipid metabolism, and inflammatory status of grow–finish pigs. A total of 300 growing pigs (body weight [BW] = 41.1 ± 6.3 kg) were randomly assigned to either a high (30 g/kg; HLA) or low (15 g/kg; LLA) dietary linoleic acid level with a high (23:1; HR), moderate (13:1; MR) or low (4:1; LR) dietary LA:ALA in a 2 × 3 factorial design. Diets were fed across three 28-d phases and were balanced for dietary metabolizable energy. Pigs were housed five pigs per pen in single-sex pens. Blood samples were collected on days 0, 21, 42, and 84, and synovial fluid was collected from the hock joint on days 0 and 84 for inflammatory marker analysis. Data were analyzed as repeated measures using PROC MIXED (SAS 9.4) with initial BW as a covariate, pen as the experimental unit, and LA level, LA:ALA, sex, phases, and their interactions as fixed effects. Compared to HLA, LLA pigs tended to have increased BW at days 56 and 84 (P = 0.088). There was no effect of LA × LA:ALA for growth performance. For the overall days 0 to 84 growth period, pigs fed HR had increased ADG compared to MR, with pigs receiving LR performing intermediate of MR and HR. Gilts receiving HR diets had increased day 84 BW compared to gilts receiving the low and moderate LA:ALA (P = 0.006), which was a result of improved overall days 0 to 84 ADG compared to gilts receiving the MR diets (P = 0.023). Barrows fed LR had improved BW on day 56 compared to MR and HR and higher final BW compared to HR, with MR performing intermediately (P = 0.006). This was a result of greater days 0 to 84 ADG (P = 0.023). Overall, C-reactive protein (CRP), tumor necrosis factor-α (TNFα), and interleukin-6 were reduced in the plasma of pigs over time (P ≤ 0.037). Across all treatments, CRP and TNFα were reduced in the hock and carpus synovial fluid on day 84 vs. day 0 (P ≤ 0.049). In conclusion, LA:ALA ratios utilized in this study can be fed at varying linoleic acid levels without impacting growth or inflammation. Additionally, LA:ALA ratios can differentially impact the growth of gilts and barrows.
A century of Illinois hover flies (Diptera: Syrphidae): museum and citizen science data reveal recent range expansions, contractions, and species of potential conservation significance
Authors: Clem C Scott , Hart Lily V , McElrath Thomas C 
Published: August 2023

Abstract
Hover flies of the family Syrphidae are a highly diverse group of insects that exhibit varied life histories and provide numerous ecosystem services. Despite their importance, they are highly understudied, and many biological and distributional patterns remain unknown in regions like the midwestern United States. Data from specimens exist in regional insect collections but is largely undigitized and thus inaccessible to much of the scientific community. Here, we report our efforts to identify, recurate, and digitize thousands of specimens from the Illinois Natural History Survey Insect Collection. We then combine these data with existing datasets to compile a comprehensive checklist of Illinois hover fly fauna, assess for temporal range expansion/contraction trends, and identify species of potential conservation significance. All total, the over 20,000 specimens/records we examined revealed 209 species within 71 genera and all 4 subfamilies of Syrphidae to have ever occurred in Illinois. Based on previously published data, 68 of these species are new Illinois state records and 36 expand the previously known range significantly. Numerous species found in Illinois historically have only recently been reported further north, while others of historically southern distribution appear to be extending their range northward, possibly due to anthropogenic factors like climate change. Furthermore, 73 species have not been reported in Illinois since at least 1995, and 27 are deemed to be of potential conservation significance with few to no recent records in the Midwest or elsewhere. Our findings illustrate the importance of routine expansion, curation, and digitization of natural history collections.
Efficacy of an enhanced recovery after surgery pathway to manage pain, nausea and vomiting after head and neck surgeries with free tissue transfer reconstruction
Authors: Imai Takayuki , Takasago Teiko , Momma Yumiko , Chiba Tomoyo , Nakanome Ayako , Morita Sinkichi , Hasegawa Kohsei , Ito Kazue , Goto Takahiro , Asada Yukinori 
Published: August 2023

Abstract

Background
Pain and post-operative nausea and vomiting are the main factors that impair the quality of recovery after surgery. Very few reports have analyzed patient-reported outcomes to investigate the efficacy of an enhanced recovery after surgery protocol to alleviate these symptoms after head and neck surgeries with free tissue transfer reconstruction.

Methods
We investigated post-operative pain and post-operative nausea and vomiting in 47 patients who underwent head and neck surgeries with free tissue transfer reconstruction with enhanced recovery after surgery support between February 2021 and August 2022. Patient-reported outcomes were assessed using the visual analog scale and Japanese version of the Quality of Recovery-40.

Results
Significant increases in the mean visual analog scale scores for pain and post-operative nausea and vomiting were observed only on post-operative Day 1 compared with preoperative values (pain: 3.19 ± 2.78 vs. 1.96 ± 2.42, P = 0.0408; post-operative nausea and vomiting: 1.52 ± 2.09 vs. 0.54 ± 1.37, P = 0.0194). From post-operative Day 2, there were no significant differences between the pre- and post-operative visual analog scale scores, and no significant increases in the incidences of moderate or severe pain and post-operative nausea and vomiting compared with preoperatively. The Japanese version of the Quality of Recovery-40 score for post-operative pain showed no significant deterioration compared with preoperatively, while the Japanese version of the Quality of Recovery-40 score for post-operative nausea and vomiting showed significant deterioration compared with the preoperative value on post-operative Days 2, 4 and 7.

Conclusions
The visual analog scale and Japanese version of the Quality of Recovery-40 scores for post-operative pain and visual analog scale score for post-operative nausea and vomiting suggested that the enhanced recovery after surgery strategy favorably controlled pain and post-operative nausea and vomiting after head and neck surgeries with free tissue transfer reconstruction. However, as the post-operative Japanese version of the Quality of Recovery-40 score for post-operative nausea and vomiting was lower than the preoperative value, there is still a need for further improvement of the enhanced recovery after surgery pathway.
The transcriptional activator Klf5 recruits p300-mediated H3K27ac for maintaining trophoblast stem cell pluripotency
Authors: Dou Chengli , Wu Linhui , Zhang Jingjing , He Hainan , Xu Tian , Yu Zhisheng , Su Peng , Zhang Xia , Wang Junling , Miao Yi-Liang , Zhou Jilong 
Published: August 2023

AbstractThe effective proliferation and differentiation of trophoblast stem cells (TSCs) is indispensable for the development of the placenta, which is the key to maintaining normal fetal growth during pregnancy. Kruppel-like factor 5 (Klf5) is implicated in the activation of pluripotency gene expression in embryonic stem cells (ESCs), yet its function in TSCs is poorly understood. Here, we showed that Klf5 knockdown resulted in the downregulation of core TSC-specific genes, consequently causing rapid differentiation of TSCs. Consistently, Klf5-depleted embryos lost the ability to establish TSCs in vitro. At the molecular level, Klf5 preferentially occupied the proximal promoter regions and maintained an open chromatin architecture of key TSC-specific genes. Deprivation of Klf5 impaired the enrichment of p300, a major histone acetyl transferase of H3 lysine 27 acetylation (H3K27ac), and further reduced the occupancy of H3K27ac at promoter regions, leading to decreased transcriptional activity of TSC pluripotency genes. Thus, our findings highlight a novel mechanism of Klf5 in regulating the self-renewal and differentiation of TSCs and provide a reference for understanding placental development and improving pregnancy rates.
Evaluation of In2Care mosquito stations for suppression of the Australian backyard mosquito, Aedes notoscriptus (Diptera: Culicidae)
Authors: Paris Véronique , Bell Nicholas , Schmidt Thomas L , Endersby-Harshman Nancy M , Hoffmann Ary A 
Published: August 2023

Abstract
Aedes notoscriptus (Skuse) is a container-inhabiting mosquito endemic to Australia that vectors arboviruses and is suspected to transmit Mycobacterium ulcerans, the cause of Buruli ulcer. We evaluated the effectiveness of the In2Care station, which suppresses mosquito populations via the entomopathogenic fungus, Beauveria bassiana, and the insect growth regulator pyriproxyfen, the latter of which is autodisseminated among larval habitats by contaminated mosquitoes. A field trial was conducted using 110 In2Care stations in a 50,000 m2 area and results were compared to 4 control areas that did not receive the treatment. Efficacy was evaluated by comparing egg counts and measuring larvicidal impact in surrounding breeding sites. Laboratory experiments validated the effect of B. bassiana on adult survival. Results of this field trial indicate that, 6 wk after the In2Care stations were deployed, treatment site ovitraps contained 43% fewer eggs than control site ovitraps, and 33% fewer eggs after 10 wk, suggesting that the In2Care station was able to reduce the egg density of Ae. notoscriptus. Population reduction remained evident for up to 3 wk after In2Care stations were removed. Treatment site ovitraps had significantly fewer Ae. notoscriptus eclosing than control site ovitraps, confirming the pyriproxyfen autodissemination feature of the stations. An average reduction of 50% in adult eclosion was achieved. Exposure to B. bassiana resulted in four-times higher mortality among adult mosquitoes. Additionally, using fresh In2Care nettings led to an 88% decrease in average survival compared to 4-wk-old nettings. The use of In2Care stations has potential for suppressing Ae. notoscriptus egg density.
Could conditioned medium be used instead of stem cell transplantation to repair spinal cord injury in animal models? Identifying knowledge gaps
Authors: Hajisoltani Razieh , Taghizadeh Mona , Hamblin Michael R , Ramezani Fatemeh 
Published: August 2023

Abstract
The drawbacks of stem cell (SC) therapies have led to investigations of SC conditioned medium (CM) instead of SC transplantation in the repair of spinal cord injury (SCI). However, the effectiveness of CM in comparison with cell transplantation in SCI models remain an open and intriguing question. The focus of this review was to survey existing publications addressing this comparison. The review included articles from electronic databases Medline, Embase, Scopus, and Web of Science that included comparisons of the effects of CM versus SC transplantation and versus controls on locomotion after SCI. The search yielded 5 studies and 6 experiments. The results indicated that there was insufficient evidence to conclude that treatment with CM and source cells were equally effective (SMD = 0.12; 95% CI = −0.36 to 0.59; p = 0.07). Regarding investigations of separate effects of SCs versus CM, there currently is limited evidence on efficacy in SCI models. This highlights a notable concern affecting this field. Thus, we identified critical knowledge gaps concerning comparisons of the efficacy of therapeutic application of SC and their derived CM on functional recovery following SCI.
Confidence tubes for curves on SO(3) and identification of subject-specific gait change after kneeling
Authors: Telschow Fabian J E , Pierrynowski Michael R , Huckemann Stephan F 
Published: August 2023

AbstractIn order to identify changes of gait patterns, e.g. due to prolonged occupational kneeling, which might be a major risk factor for the development of knee osteoarthritis, we develop confidence tubes for curves following a perturbation model on SO(3) using the Gaussian kinematic formula which are equivariant under gait similarities and have precise coverage even for small sample sizes. Applying them to gait curves from eight volunteers undergoing kneeling tasks and adjusting for different walking speeds and marker replacement at different visits, allows us to identify at which phases of the gait cycle the gait pattern changed due to kneeling.
Influenza: seasonality and travel-related considerations
Authors: Kakoullis Loukas , Steffen Robert , Osterhaus Albert , Goeijenbier Marco , Rao Sowmya R , Koiso Satoshi , Hyle Emily P , Ryan Edward T , LaRocque Regina C , Chen Lin H 
Published: August 2023

Abstract

Rationale for review
This review aims to summarize the transmission patterns of influenza, its seasonality in different parts of the globe, air travel- and cruise ship-related influenza infections and interventions to reduce transmission.

Key findings
The seasonality of influenza varies globally, with peak periods occurring mainly between October and April in the northern hemisphere (NH) and between April and October in the southern hemisphere (SH) in temperate climate zones. However, influenza seasonality is significantly more variable in the tropics. Influenza is one of the most common travel-related, vaccine-preventable diseases and can be contracted during travel, such as during a cruise or through air travel. Additionally, travellers can come into contact with people from regions with ongoing influenza transmission. Current influenza immunization schedules in the NH and SH leave individuals susceptible during their respective spring and summer months if they travel to the other hemisphere during that time.

Conclusions/recommendations
The differences in influenza seasonality between hemispheres have substantial implications for the effectiveness of influenza vaccination of travellers. Health care providers should be aware of influenza activity when patients report travel plans, and they should provide alerts and advise on prevention, diagnostic and treatment options. To mitigate the risk of travel-related influenza, interventions include antivirals for self-treatment (in combination with the use of rapid self-tests), extending the shelf life of influenza vaccines to enable immunization during the summer months for international travellers and allowing access to the influenza vaccine used in the opposite hemisphere as a travel-related vaccine. With the currently available vaccines, the most important preventive measure involves optimizing the seasonal influenza vaccination. It is also imperative that influenza is recognized as a travel-related illness among both travellers and health care professionals.
Custom Iris Prosthesis for Subtotal Traumatic Aniridia From Combat Ocular Trauma
Authors: Gensheimer William G 
Published: August 2023

ABSTRACT
Traumatic aniridia from combat ocular trauma can cause visual disability. A 41-year-old male Army Veteran was referred for evaluation of light sensitivity and glare secondary to subtotal traumatic aniridia of his left eye from an improvised explosive device blast. A custom-made artificial iris prosthesis was implanted in the ciliary sulcus and secured using Gore-Tex sutures. After surgery, the patient reported improvement of his light sensitivity and quality of life. The custom iris prosthesis is a surgical option for visual disability resulting from traumatic aniridia from combat ocular trauma.
Constraints to the semimajor axis of outer particles with nodal librations by general relativity effects
Authors: Zanardi M , de Elía G C , Dugaro A , Coronel C F 
Published: August 2023

ABSTRACT
We study nodal librations of outer particles in the framework of the elliptical restricted three-body problem including general relativity (GR) effects. From an analytical treatment based on secular interactions up to quadrupole level, we derive equations that define the nodal libration region of an outer test particle, which depends on the physical and orbital parameters of the bodies of the system. From this, we analyse how the GR constrains the semimajor axis of outer test particles that experience nodal librations under the effects of an inner planet around a single stellar component. Such an upper limit of the semimajor axis, which is called a2,lim, depends on the mass of the star ms, the mass m1, the semimajor axis a1, and the eccentricity e1 of the inner planet, and the eccentricity e2 of the outer test particle. On the one hand, our results show that the greater m1, a1, and e2 and the smaller ms, the greater the value of a2,lim. On the other hand, for fixed ms, m1, a1, and e2, a2,lim does not strongly depend on e1, except for large values of such an orbital parameter. We remark that N-body experiments of particular scenarios that include GR show results consistent with the analytical criteria derived in this research. Moreover, the study of hypothetical small body populations of real systems composed of a single star and an inner planetary-mass companion show that the GR effects can play a very important role in their global dynamics.