bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling and assessment of the flow and air pollutants dispersion during chemical reactions from power plant activities
Authors: Issakhov Alibek , Alimbek Aidana 
Published: March 2023

Abstract
In this work, numerical modeling and assessment of the dispersion of pollutants as a result of a chemical reaction from the activities of the Ekibastuz SDPP-1 was considered. The simulation was done on a valid thermal power plant. At the same time, to model the dispersion of pollutants NO, NO2 and CO were used, and the products NO2, HNO3 and CO2 from a chemical reaction with oxygen were also considered. The validation of the mathematical model, taking into account the chemical reaction, was carried out using several test problems and the obtained numerical results were compared with experimental data and numerical data of other authors. So in this work, estimates of the concentration level were given, both for pollutants and for products that were formed from a chemical reaction. As a result, the mass fractions of concentration and product were determined during a chemical reaction for various distances from chimneys. According to the data obtained, it can be noticed that, under the influence of diffusion, concentrations and products during a chemical reaction spread wider in width and due to this diffusion, the concentration level with an increase in the distance from the chimneys is lower. So, according to the data obtained, it is possible to assess the choice of the optimal distance of the thermal power plant from residential areas, at which the concentration of emissions and products from a chemical reaction will remain at a safe level.
Downregulation of RBM17 enhances cisplatin sensitivity and inhibits cell invasion in human hypopharyngeal cancer cells
Authors: Wang Xiaolin , Chen Deshang , Han Guoying , Wang Xiaomin , Liu Xuebao , Xu Binbin , Liu Weiwei , Li Hui , Zhang Mingjie , Ma Shiyin , Han Yuefeng 
Published: March 2023

Abstract
Most of advanced hypopharyngeal squamous cell carcinoma (HSCC) are resistant to chemotherapy, and there is still lack of effective treatment for HSCC now. The present study aimed to investigate whether downregulation of RNA-binding motif protein 17 (RBM17) could enhance cisplatin sensitivity and inhibit cell invasion in HSCC and the underlying mechanism. We observed that RBM17 was upregulated in tumor tissues and associated with poor progression. Treatment of FaDu cells with cisplatin increased RBM17 expression in mRNA levels. Downregulation of RBM17 enhanced cisplatin-mediated inhibition of FaDu cells. In addition, downregulation of RBM17 effectively suppressed tumor cell migration and invasion through the reversion of epithelial–mesenchymal transition. Moreover, downregulation of RBM17 could significantly slow tumor growth in FaDu xenograft tumor model. Liquid chromatography–mass spectrometry/mass spectrometry detection and independent PRM analysis showed that 21 differentially expressed proteins were associated with the downregulation of RBM17. Taken together, our study implied that downregulation of RBM17 could serve as a novel approach to enhance cisplatin sensitivity in HSCC.
The effect of removing a 2-downer edge or a cut 2-downer edge triangle for an eigenvalue
Authors: Toyonaga Kenji 
Published: March 2023

Abstract
Edges in the graph associated with a square matrix over a field may be classified as to how their removal affects the multiplicity of an identified eigenvalue. There are five possibilities:

+
2

+2

(2-Parter);

+
1

+1

(Parter); no change (neutral);

−
1

-1

(downer); and

−
2

-2

(2-downer). Especially, it is known that 2-downer edges for an eigenvalue comprise cycles in the graph. We investigate the effect for the statuses of other edges or vertices by removing a 2-downer edge. Then, we investigate the change in the multiplicity of an eigenvalue by removing a cut 2-downer edge triangle.
Blue Print Plant Model
Authors: Lange Annika , Magret Ihnen Deike , Knothe Thomas 
Published: March 2023

Abstract
In den letzten beiden Dekaden sind die Unsicherheiten und Abhängigkeiten externer Faktoren bei der Fabrikplanung gestiegen. Immer relevanter wird eine Datendurchgängigkeit, die quer zu den Planungsphasen verbessert wird, sodass externe und interne Änderungen sowie deren Auswirkungen auf die Planungsobjekte einfacher und schneller bewertet werden können. In dem Beitrag wird ein Konzept vorgestellt, welches mithilfe eines verteilten digitalen Fabrikzwillings, bereits in der frühen Planungsphase die Durchgängigkeit unterstützt. Die Vernetzung der Komponenten wird durch ein Unternehmensmodell realisiert, das entlang des Fabriklebenszyklus aufgebaut und angewendet wird.
Optimierte Auswahl von Fabrikelementen
Authors: Kreß Antonio , Metternich Joachim 
Published: March 2023

Abstract
Bei der Planung von Fabriken bestimmt die geeignete Auswahl der Fabrikelemente, wie gut eine Fabrik ihren geplanten Zweck erfüllt. Die Herausforderung bei den Auswahlentscheidungen besteht darin, die bestmögliche Auswahl in Bezug auf ein geplantes Ziel zu treffen, während gleichzeitig bestimmte Restriktionen, wie z. B. bei Budget oder Flächen, eingehalten werden müssen. In der Regel werden die Entscheidungen zur Auswahl von Fabrikelementen für jeden Fabrikbereich separat getroffen. Dabei wird entweder intuitiv oder auf der Basis von Heuristiken vorgegangen. In diesem Beitrag wird gezeigt, wie die Auswahl auf Basis eines ganzheitlichen Optimierungsansatzes erfolgen kann, durch das eine nutzenoptimale Fabrikkonfiguration unter Betrachtung vorab definierter Budgets ermöglicht wird. Darüber hinaus werden ein einfaches, vierstufiges Vorgehen sowie ein softwarebasiertes Konfigurationssystem vorgestellt. Das Optimierungsmodell wurde genutzt, um die Forschungs- und Lernfabrik FlowFactory des Forschungsinstituts PTW zu konfigurieren.
Energieoptimierte Produktionsplanung
Authors: Eckhoff Jannis , Adomat Vincent , Fette Marc 
Published: March 2023

Abstract
Faserverbundwerkstoffe sind ein wesentlicher Bestandteil der modernen Luftfahrtindustrie und einer der wichtigsten Treiber eines ressourceneffizienten Betriebs. Die energieoptimierte Verarbeitung von Kohlenstofffasern gewinnt dabei zunehmend an Bedeutung. Dieser Beitrag stellt aktuelle Bestrebungen zur Optimierung des Energieeinsatzes industrieller Faserverbundverarbeitung dar. Erneuerbare Energie bietet ein hohes Potenzial bei der Optimierung der Produktion, deren Grundlage die detaillierte Kenntnis der Energieintensität ist. Digitalisierung liefert die Erkenntnisse für eine solche Optimierung.
Zieltransformation in Ganzheitlichen Produktionssystemen
Authors: Dombrowski Uwe , Dreyer Maximilian 
Published: March 2023

Abstract
Zielorientierung in Ganzheitlichen Produktionssystemen ist essenziell für den wirtschaftlichen Erfolg produzierender Unternehmen. Handelnde müssen erkennen, welche Prozesse einen Zielbeitrag leisten und welches Verbesserungspotenzial in ihnen liegt. Vielschichtige Zielsysteme, unklare Zielbeiträge und eine hohe Methodenvielfalt erschweren die Zielausrichtung von Prozessen über Bereichs- und Prozessgrenzen hinweg. Dieser Beitrag benennt die Herausforderungen und schlägt einen Ansatz zu deren systematischer Bewältigung vor.
Exploring Canadian Career Firefighters’ Understanding of the Return-to-Work Process after Musculoskeletal Injuries
Authors: Killip Shannon 
Published: March 2023

BACKGROUND: Firefighters perform dangerous and physically demanding work, increasing their risk of musculoskeletal injuries that can lead to work absences. Return-to-work procedures can help firefighters return-to-work. The purpose was to explore what firefighters understand about return-to-work procedures in their workplaces, and what firefighters believe the facilitators and barriers to return-to-work are.
METHODS: Thirty-eight Canadian career firefighters were recruited for semi-structured interviews. Qualitative description methods were used to analyze the transcripts. Two researchers performed the inductive coding and thematic analysis.
RESULTS: Five themes were identified: 1. Variation in the return-to-work process knowledge among firefighters; 2. Accessible medical resources and treatments for the recovery of an injury; 3. Modified work must be meaningful and suitable; 4. Pressures to return-to-work too soon can lead to negative consequences; 5. Heavy physical demands of firefighting can make it more difficult to return-to-work. There was a variation in the experiences and understanding of return-to-work, as some firefighters were unaware of return-to-work procedures in their departments, while others had been through the return-to-work process for injuries they had sustained. Many reported facilitators for return-to-work were also reported as barriers in different contexts. For example, the availability of modified work allowed firefighters to return-to-work sooner and was seen as a facilitator by many firefighters, whereas some firefighters believed that the modified work lacked meaning, was not suitable, and acted as a barrier to returning to firefighting duties.
CONCLUSION: There is a lack of knowledge of the return-to-work processes; thus, firefighters should have access to clear return-to-work policies and procedures. Firefighters require treatments that are targeted to firefighting duties to help recover from injuries and regain functional physical abilities after an injury. Firefighters must be fully recovered, as returning to work too soon due to personal and workplace pressures can lead to re-injury or injuries to others.
Fall Risk Factors in Community-Dwelling Older Adults: An Umbrella Review Protocol
Authors: Saunders Stephanie 
Published: March 2023

BACKGROUND: Falls are among the leading cause of accidental injury in Canada, with one in three older adults experiencing a fall each year. This leads to disability, long-term pain, loss of independence, reduced quality of life, mental health challenges, and increased mortality risk. Alongside these injuries, falls are a growing national public health concern given their direct cost of over $2 billion a year. Further, with an aging Canadian population, the prevalence and incidence of falls are expected to increase at a rapid rate. A large body of literature has identified risk factors that contribute to falls in older adults, however, to date this literature has been disjointed and often groups together fall risks for different populations. To address these limitations, this review will aim to summarize the evidence identifying risk factors for falls in community-dwelling older adults (60 years).

METHODS: We searched seven databases (Medline, Embase, CINAHL, Cochrane Library, PsychINFO, Ageline) for articles that: are systematic reviews (including scoping reviews), include a population of community dwelling older adults (60 years), and report modifiable and non-modifiable factors that have shown to increase the risk for falls in prospective studies. Multiple independent reviewers will screen titles, abstracts, and full text articles, and perform data extraction and quality assessment. Risk factors will be synthesized narratively. Wherever possible, findings will be grouped according to the International Classification of Functional Disability (ICF).

ANTICIPATED IMPACT: Given the substantial amount of research conducted in this area, we anticipate that the identified risk factors for falls will cover a wide breadth. Further, our results will identify the risk factors that are of the utmost importance to consider when undertaking fall prevention efforts.
The Fusion of Public Health and Speech-Language Therapy in Schools: Has the Time Come?
Authors: Cahill Peter , Campbell Wenonah N 
Published: March 2023

BACKGROUND: The burden of communication disorders in school age children is substantial. These disorders are among the most prevalent in schools. Communication disorders are also linked to numerous sequalae, such as poor socio-emotional health, poor academic and professional outcomes, high levels of unemployment, and increased healthcare utilization and costs. Nevertheless, children with these disorders are among the least likely to receive services from a rehabilitation professional. In fact, more than half of school-aged children with a communication disorder do not receive any speech-language therapy support. Clearly, new approaches to communication disorders in schools are needed.

METHODS: We conducted a narrative review of scholarly and applied literature in three parts. The first justifies the fusion of public health and speech-language therapy in schools. The second explores public health frameworks for speech-language therapy and compares the same to tiered service delivery models recently implemented within schools. The third addresses the implications of this fusion for research in communication disorders and for clinical practice.

RESULTS: Traditional models of speech-language therapy clinical practice in schools are no longer sustainable given the current challenges posed by childhood communication disorders. A communication disability public health approach is needed to overcome these challenges. Tiered service delivery models provide an excellent opportunity to pivot speech-language therapy practice and research in schools towards a public health approach.

CONCLUSION: Through this narrative review, we argue that the future of speech-language therapy in schools must take advantage of advances in public health to respond to current child health needs in our communities. We strongly recommend the fusion of public health and school-based speech-language therapy to address the communication health needs of future generations.
A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulation
Authors: Mao Weiguang , Miller Clare M , Nair Venugopalan D , Ge Yongchao , Amper Mary Anne S , Cappuccio Antonio , George Mary‐Catherine , Goforth Carl W , Guevara Kristy , Marjanovic Nada , Nudelman German , Pincas Hanna , Ramos Irene , Sealfon Rachel S G , Soares‐Schanoski Alessandra , Vangeti Sindhu , Vasoya Mital , Weir Dawn L , Zaslavsky Elena ,   Biobank Team, Kim‐Schulze Seunghee , Gnjatic Sacha , Merad Miriam , Letizia Andrew G , Troyanskaya Olga G , Sealfon Stuart C , Chikina Maria 
Published: March 2023

AbstractDNA methylation comprises a cumulative record of lifetime exposures superimposed on genetically determined markers. Little is known about methylation dynamics in humans following an acute perturbation, such as infection. We characterized the temporal trajectory of blood epigenetic remodeling in 133 participants in a prospective study of young adults before, during, and after asymptomatic and mildly symptomatic SARS‐CoV‐2 infection. The differential methylation caused by asymptomatic or mildly symptomatic infections was indistinguishable. While differential gene expression largely returned to baseline levels after the virus became undetectable, some differentially methylated sites persisted for months of follow‐up, with a pattern resembling autoimmune or inflammatory disease. We leveraged these responses to construct methylation‐based machine learning models that distinguished samples from pre‐, during‐, and postinfection time periods, and quantitatively predicted the time since infection. The clinical trajectory in the young adults and in a diverse cohort with more severe outcomes was predicted by the similarity of methylation before or early after SARS‐CoV‐2 infection to the model‐defined postinfection state. Unlike the phenomenon of trained immunity, the postacute SARS‐CoV‐2 epigenetic landscape we identify is antiprotective.
Intraventricular Hemorrhage in Very Preterm Children: Mortality and Neurodevelopment at Age 5
Authors: Tréluyer Ludovic , Chevallier Marie , Jarreau Pierre-Henri , Baud Olivier , Benhammou Valérie , Gire Catherine , Marchand-Martin Laetitia , Marret Stéphane , Pierrat Véronique , Ancel Pierre-Yves , Torchin Héloïse 
Published: March 2023

OBJECTIVES
The objectives were to describe mortality and causes of death in children with intraventricular hemorrhage (IVH) and to study neurodevelopmental outcomes.

METHODS
The study was a secondary analysis of the French national prospective and population-based cohort EPIPAGE-2. Children were recruited in 2011. A standardized assessment was conducted at age 5. Children born before 32 weeks’ gestation and admitted to a NICU were eligible. Exposure was IVH defined by the Papile classification. Main outcomes were mortality, causes of death, and neurodevelopmental outcomes at age 5.

RESULTS
Among the 3468 children included, 578 (16.7%) had grade 1 IVH, 424 (12.2%) grade 2 IVH, and 114 (3.3%) grade 3 IVH; 144 (4.1%) had intraparenchymal hemorrhage (IPH). Mortality was 29.7% (36 of 114) for children with grade 3 IVH and 74.4% (109 of 144) for those with IPH; 67.6% (21 of 31) and 88.7% (86 of 97) of deaths, respectively, were because of withholding and withdrawing of life-sustaining treatment. As compared with no IVH, low-grade IVH was not associated with measured neurodevelopmental disabilities at age 5. High-grade IVH was associated with moderate and severe neurodevelopmental disabilities, reduced full-scale IQ, and cerebral palsy.

CONCLUSIONS
Rates of neurodevelopmental disabilities at age 5 did not differ between children without IVH and those with low-grade IVH. For high-grade IVH, mortality rate was high, mostly because of withholding and withdrawal of life-sustaining treatment, and we found a strong association with overall neurodevelopmental disabilities in survivors.
МАТЕМАТИЧНА МОДЕЛЬ ДЛЯ РОЗРАХУНКУ ПОХИБОК ОЦІНЮВАННЯ КУТОВИХ ШВИДКОСТЕЙ КОСМІЧНОГО АПАРАТА
Authors: Sidorov I. , Manoilenko А. 
Published: March 2023

В даний час відзначається підвищений інтерес до створення беcплатформенних інерційних навігаційних систем (БІНС), які складають інформаційне ядро ​​сучасних бортових комплексів орієнтації та навігації космічних апаратів (КА). БІНС можуть включати магнітометри, астродатчики, датчики кутових швидкостей (ДКШ). Точність орієнтації КА багато в чому залежить від складу БІНС. Наявність ДКШ в складі БИНС забезпечує кращу точність. У зв'язку з цим завдання, які пов'язані з фільтрацією "зашумлених" даних з ДКШ, оцінюванням і розрахунком похибок оцінок, калібруванням датчиків БІНС, є актуальними. У даній роботі запропонована математична модель для вирішення задачі розрахунку похибок оцінювання кутових швидкостей КА з урахуванням фільтрації "зашумлених" даних ДКШ. Модель включає: дискретну модель об'єкта спостереження - ДКШ і модель процесу вимірювань, яка враховує такі параметри ДКШ як нестабільність ціни імпульсу, неортогональність осей чутливості, нестабільність зміщення нулів, випадковий ухід (дрейф) датчика. В якості алгоритму фільтрації даних ДКШ про складові вектора кутової швидкості КА використаний оптимальний рекурентний фільтр Калмана, що дозволяє мінімізувати середню квадратичну помилку оцінювання вектора стану об'єкта і виділяти корисний сигнал на фоні випадкових перешкод. Такий фільтр для дискретних моделей об'єкта спостереження і процесу вимірювання дозволяє виконувати оптимальне оцінювання в реальному масштабі часу польоту КА. В якості вихідних даних прийняті параметри ДКШ типу ADIS-16350, який виконаний за MEMS-технологією. Наведено результати чисельного моделювання динамічних процесів фільтрації даних ДКШ і оцінювання кутових швидкостей КА, отримані значення похибок оцінювання.
ЦИФРОВЫЕ ПРАВА КАК НЕОТЪЕМЛЕМЫЕ ПРАВА ЧЕЛОВЕКА
Authors: САИДОВ Акмаль Холматович 
Published: March 2023

Автор отмечает необходимость переосмысления прав человека на получение информации в связи с трансформацией права и правовых институтов с учетом возможностей цифровых технологий на фоне формирования глобального информационного общества. В современных условиях главной задачей государства становится усовершенствование законодательства в области информации для предотвращения нарушений прав на неприкосновенность частной жизни, связанных с раскрытием личной и конфиденциальной информации в интернете.
ПРОБЛЕМЫ ИСПОЛЬЗОВАНИЯ СОЦИАЛЬНЫХ СЕТЕЙ В КАЧЕСТВЕ СРЕДСТВА ПОЛИТИЧЕСКОЙ КОММУНИКАЦИИ
Authors: АЖЕНЕ Абонго Машоод Жакоб 
Published: March 2023

Социальные медиа — самое популярное в мире средство политической коммуникации во всех политических структурах. Они стали платформой как для политических элит, так и для «низов», платформой, позволяющей общаться с гражданами и электоратом в избирательном округе, даже в мире международной политики. Основная цель данного исследования — определить проблемы социальных медиа как средства политической коммуникации. Социальные медиа являются жизненно важным инструментом для распространения массовой информации, однако некоторые лидеры не используют социальные медиа и даже не имеют ни одного аккаунта в социальных сетях. В рамках исследования попытамся определить причины этого.
Результаты исследования подчеркивают роль социальных медиа в современной политической коммуникации, проблемы, с которыми сталкиваются социальные медиа в области политической дезинформации, ложной идентичности, фальшивых новостей, интернет-фобии, а также влияние руководителей социальных медиа, которые подрывают их как средство политической коммуникации.
ОРИГИНАЛЬНОСТЬ ПРОИЗВЕДЕНИЯ КАК КРИТЕРИЙ ОХРАНОСПОСОБНОСТИ
Authors: ИСАЕВА Ольга Владимировна 
Published: March 2023

C развитием технологий на практике все чаще возникают споры о защите прав на те или иные объекты. Если российское законодательство прямо закрепляет лишь два требования к произведениям для их охраноспособности (результат творческой деятельности и выраженность в объективной форме), исходя из которых суды и вынуждены осуществлять оценку, то зарубежные законодательство и практика учитывают и иной критерий — оригинальность произведения. Автором статьи предпринята попытка продемонстрировать целесообразность придания критерию оригинальности силы условия охраноспособности произведения.
Artificial intelligence in orthodontics: A way towards modernization
Authors: Younus A Abrar , Ahmed Nausheer , Aymen Uroosa , Rahul N A 
Published: March 2023

Recent years, artificial intelligence technology has been a revolutionary tool in health care system, an increase in application of the technology noted significantly in Orthodontics as well. AI is an outstanding tool to help orthodontists as it can be utilized from the beginning to diagnose till the planning of the treatment. Along with speeding up the diagnosis and treatment processes, automation can cut labour expenses to zero.A well-trained AI model, which simulates human intelligence through machines, can aid in all kinds of linear, angular, and volumetric measurements in addition to helping identify landmarks, greatly reducing measurement time so that researchers can focus their efforts on discovering novel clinical insights. In this review article, artificial intelligence in orthodontics is discussed in relation to its use to clinical decision-making, diagnosis and treatment planning, estimation of growth and development, evaluating the facial proportion, prediction of cephalometric land mark and force system and also in analysing the soft tissue treatment outcomes.