bluuebunny/crossref_metadata_2025_split huggingface dataset:
Training Load Quantification in Women’s Elite Football: A Season-Long Prospective Cohort Study
Authors: Karlsson Ulrik B. , Vagle Markus , Wiig Håvard , Luteberget Live S. 
Published: April 2023

The aim of this study was to investigate (1) if there are differences in training load and intensity between the different training days within a microcycle and (2) if training load and intensity within the different training days are stable over the course of a season. Data were collected over a full season from a team in the women’s premier division in Norway. External load (total distance, high-speed-running distance, sprint distance, and the combined number of accelerations and decelerations [ACCDEC]) was assessed using a 10-Hz GPS system with a built-in accelerometer. Internal load was assessed through session rating of perceived exertion, which was multiplied with session duration (session rating of perceived exertion-load). Training days were classified in relation to their proximity to the upcoming match day (MD): MD − 4, MD − 3, MD − 2, and MD − 1. Contents on these days were standardized according to a weekly periodization model followed by the coaching staff. Differences between training days were analyzed using a linear mixed-effects model. All training days were significantly different from each other across multiple variables. ACCDEC values were highest on MD − 4 (147.5 [13.0] ACCDEC count), and all distance variables were highest on MD − 3. All measures of training load were significantly reduced from MD − 3 to MD − 2 (effect size [ES] = 1.0–4.1) and from MD − 2 to MD − 1 (ES = 1.6-4.3). A significant negative effect across the season was observed for session rating of perceived exertion-load and ACCDEC (ES = 0.8–2.1). These results provide evidence that elite female football teams can be successful in differentiating training load between training days when implementing a weekly periodization approach.
Estimated neonatal survival of very preterm births across the care pathway: a UK cohort 2016–2020
Authors: Seaton Sarah E , Agarwal Ridhi , Draper Elizabeth S , Fenton Alan C , Kurinczuk Jennifer J , Manktelow Bradley N , Smith Lucy K 
Published: April 2023

ObjectiveCurrently used estimates of survival are nearly 10 years old and relate to only those babies admitted for neonatal care. Due to ongoing improvements in neonatal care, here we update estimates of survival for singleton and multiple births at 22+0to 31+6weeks gestational age across the perinatal care pathway by gestational age and birth weight.DesignRetrospective analysis of routinely collected data.SettingA national cohort from the UK and British Crown Dependencies.PatientsBabies born at 22+0to 31+6weeks gestational age from 1 January 2016 to 31 December 2020.InterventionsNone.Main outcome measuresSurvival to 28 days.ResultsEstimates of neonatal survival are provided for babies: (1) alive at the onset of care during the birthing process (n=43 763); (2) babies where survival-focused care was initiated (n=42 004); and (3) babies admitted for neonatal care (n=41 158). We have produced easy-to-use survival charts for singleton and multiple births. Generally, survival increased with increasing gestational age at birth and with increasing birth weight. For all births with a birthweight over 1000 g, survival was 90% or higher at all three stages of care.ConclusionsSurvival estimates are a vital tool to support and supplement clinical judgement within perinatal care. These up-to-date, national estimates of survival to 28 days are provided based on three stages of the perinatal care pathway to support ongoing clinical care. These novel results are a key resource for policy and practice including counselling parents and informing care provision.
BiallelicNPR1loss of function variants are responsible for neonatal systemic hypertension
Authors: Capri Yline , Kwon Theresa , Boyer Olivia , Bourmance Lucas , Testa Noe , Baudouin Véronique , Bonnefoy Ronan , Couderc Anne , Meziane Chakib , Tournier-Lasserve Elisabeth , Heidet Laurence , Melki Judith 
Published: April 2023

BackgroundEarly-onset isolated systemic hypertension is a rare condition of unknown genetic origin. Renovascular, renal parenchymal diseases or aortic coarctation are the most common causes of secondary systemic hypertension in younger children and neonates. We investigated the genetic bases of early-onset isolated systemic hypertension.MethodsWhole-exome sequencing (WES) was followed by variant filtering and Sanger sequencing for validation and familial segregation of selected variants in a large consanguineous family. mRNA expression was performed to evaluate the impact of the predicted pathogenic variant on gene expression. WES or Sanger sequencing was performed in additional unrelated affected individuals.ResultsIn one consanguineous family with four children presenting with isolated neonatal-onset systemic hypertension, we identified homozygous stop–gain variant in theNPR1gene (NM_000906.4:c.1159C>T (p.Arg387Ter)) in the affected individuals. This variant leads to a dramatic reduction of NPR1 RNA levels.NPR1gene analysis of additional families allowed the identification of another family with two affected children carrying homozygous frameshift variant inNPR1(NM_000906.4:c.175del (p.Val59TrpfsTer8)).ConclusionWe show for the first time that biallelic loss of function ofNPR1is responsible for isolated neonatal-onset systemic hypertension in humans, which represents a new autosomal recessive genetic cause of infantile systemic hypertension or cardiogenic shock. This is consistent with studies reporting early-onset systemic hypertension and sudden death in Npr1-deficient mice.NPR1gene analysis should be therefore investigated in infants with early-onset systemic hypertension with or without cardiogenic shock of unknown origin.
Matter radius of the doubly-magic $$^{56}$$Ni measured in a storage ring
Authors: von Schmid M. , Aumann T. , Bagchi S. , Bönig S. , Csatlós M. , Dillmann I. , Dimopoulou C. , Egelhof P. , Eremin V. , Furuno T. , Geissel H. , Gernhäuser R. , Harakeh M. N. , Hartig A.-L. , Ilieva S. , Kalantar-Nayestanaki N. , Kiselev O. , Kollmus H. , Kozhuharov C. , Krasznahorkay A. , Kröll Th. , Kuilman M. , Litvinov S. , Litvinov Yu. A. , Mahjour-Shafiei M. , Mutterer M. , Nagae D. , Najafi M. A. , Nociforo C. , Nolden F. , Popp U. , Rigollet C. , Roth R. , Roy S. , Scheidenberger C. , Steck M. , Streicher B. , Stuhl L. , Thürauf M. , Uesaka T. , Weick H. , Winfield J. S. , Winters D. , Woods P. J. , Yamaguchi T. , Yue K. , Zamora Cardona J. C. , Zenihiro J. ,   EXL Collaboration
Published: April 2023

AbstractThe matter radius of the doubly magic$$^{56}$$56Ni was extracted from a measurement of the differential cross section by employing, for the first time, elastic proton scattering in inverse kinematics with a radioactive beam at$$E_{kin}=390.2$$Ekin=390.2 MeV/nucleon circulating in a storage ring and passing an internal hydrogen gas-jet target with a revolution frequency of around 2 MHz. The novel experimental scheme is based on UHV-compatible Si detectors operated as active vacuum windows, which were implemented in the ESR storage ring at GSI. A matter radius$$<r_{m}^{2}>^{1/2}=3.74^{+0.03}_{-0.06}$$<rm2>1/2=3.74-0.06+0.03 fm was extracted for the doubly-magic self-conjugate nucleus$$^{56}$$56Ni.
A bouncing cosmology from VECROs
Authors: Brandenberger Robert , Mitchell Gabrielle A. 
Published: April 2023

AbstractWe argue that, in the same way that in a black hole space-time VECROs will form in order to cancel the gravitational effects of a collapsing mass shell and prevent the formation of a singularity, in a contracting universe a gas of VECROs will form to hold up the contraction, prevent a Big Crunch singularity, and lead to a nonsingular cosmological bounce.
An Evaluation Study of 2D and 3D Teleconferencing for Remote Physical Therapy
Authors: Jun Hanseul , Shaik Husam , DeVeaux Cyan , Lewek Michael , Fuchs Henry , Bailenson Jeremy 
Published: April 2023

Abstract
The present research investigates the effectiveness of using a telepresence system compared to a video conferencing system and the effectiveness of using two cameras compared to one camera for remote physical therapy. We used Telegie as our telepresence system, which allowed users to see an environment captured with RGBD cameras in 3D through a VR headset. Since both telepresence and the inclusion of a second camera provide users with additional spatial information, we examined this affordance within the relevant context of remote physical therapy. Our dyadic study across different time zones paired 11 physical therapists with 76 participants who took on the role of patients for a remote session. Our quantitative questionnaire data and qualitative interviews with therapists revealed several important findings. First, after controlling for individual differences among participants, using two cameras had a marginally significant positive effect on physical therapy assessment scores from therapists. Second, the spatial ability of patients was a strong predictor of therapist assessment. And third, the video clarity of remote communication systems mattered. Based on our findings, we offer several suggestions and insights towards the future use of telepresence systems for remote communication.
What Determines the Leading Mode of Wintertime Northern Hemisphere Snow-Cover Interannual Variability?
Authors: Luo Yue , Yang Xiu-Qun , Sun Linyuan , Tao Lingfeng 
Published: April 2023

Abstract
The Northern Hemisphere snow-cover (NHSC) interannual variability can serve as a crucial source of climate predictability. However, the spatiotemporal characteristics of the NHSC interannual variability and associated formation mechanism lack a thorough investigation using the latest reliable datasets. In this observationally based study, we identify the leading mode of the wintertime NHSC interannual variability and reveal the major determinants and mechanisms for forming the mode. Results show that the leading mode exhibits a hemispheric dipole pattern characterized by snow-cover anomalies in the central-eastern United States and Europe, contrary to those in the Tibetan Plateau (TP). Importantly, the leading mode of TP-only snow-cover variability is essentially a regional manifestation of the dipole NHSC anomaly pattern. The wintertime hemispheric atmospheric circulation anomaly mode, that is, the Arctic Oscillation (AO), primarily determines the dipole NHSC anomaly pattern via altering snowfall and snowmelt. During a positive phase of AO, an anomalous atmospheric anticyclone over the midlatitude North Atlantic favors increased warm-air advection over the central-eastern United States and Europe, reducing the snowfall and the snow cover there. Meanwhile, the anomalously warm atmospheric thermal condition in Europe accompanied by enhanced westerly moisture flux convergence tends to heat the underlying land surface via reducing upward sensible heat flux and increasing downward longwave radiation, thereby causing increased snowmelt and decreased snow cover in northeastern Europe. Associated with the aforementioned atmospheric circulation anomalies, an anomalous atmospheric cyclone prevailing over the TP tends to cause increased southeasterly moisture flux convergence, favoring snowfall and snow increase in the TP.
Examining safety and efficacy of a fixed concentration heparin dosing strategy for anticoagulation in neonatal extracorporeal membrane oxygenation
Authors: Tewary Shambhavi , Sontakke Sanket , Dean Kiri , Ellis David , Ghose Arun , Kanthimathinathan Hari Krishnan 
Published: April 2023

Objectives The paediatric intensive care unit changed heparin infusion dosing from a variable weight-based concentration to a fixed concentration strategy, when smart pump-based drug library was introduced. This change meant significantly lower rates of infusion were needed for the same dose of heparin in the neonatal population. We performed a safety and efficacy assessment of this change. Methods We performed a retrospective single-centre evaluation based on data from respiratory VA-extracorporeal membrane oxygenation (ECMO) patients weighing ≤5 kg, pre and post the change to fixed strength heparin infusion. Efficacy was analysed by distribution of activated clotting times (ACT) and heparin dose requirements between the groups. Safety was analysed using thrombotic and haemorrhagic event rates. Continuous variables were reported as median, interquartile ranges, and non-parametric tests were used. Generalised estimating equations (GEE) were used to analyse associations of heparin dosing strategy with ACT and heparin dose requirements in the first 24 h of ECMO. Incidence rate ratios of circuit related thrombotic and haemorrhagic events between groups were analysed using Poisson regression with offset for run hours. Results 33 infants (20 variable weight-based, 13 fixed concentration) were analysed. Distribution of ACT ranges and heparin dose requirements were similar between the two groups during the ECMO run and this was confirmed by GEE. Incidence rate ratios of thrombotic (fixed v weight-based) (1.9 [0.5–8], p = .37), and haemorrhagic events (0.9 [0.1–4.9], p = .95) did not show statistically significant differences. Conclusions Fixed concentration dosing of heparin was at least equally effective and safe compared to a weight-based dosing.
Danger of floating venous thrombosis: myth or reality?
Authors: Chernukha Larisa , Khrebtiy Yaroslav , Khrebtii Halyna 
Published: April 2023

Introduction To date, the problem of venous thromboembolism and its consequences remains relevant, despite significant progress in the development of phlebology and technologies. Aim In our study, we tried to assess the “danger” of floating DVTs, methods and features of conservative and surgical treatment of patients with floating DVTs, analyze the results of treatment of this group of patients, and draw conclusions based on our data. Materials and methods The results of treatment of 1297 patients with venous thromboembolism for the period 2011–2022 were analyzed. 104 patients were treated with floating deep vein thrombosis, 1193 patients had occlusive proximal venous thrombosis. Results In our study, we determined the danger of floating DVT by comparing the facts of the migration of thrombotic masses in the proximal direction according to the results of treatment in two groups of patients. The first group consisted of 10 patients with proximal floating venous thromboses who were implanted with cava filters, the second group consisted of 28 patients with occlusive proximal venous thrombosis who were implanted with cava filters. Embolism occurred in 40.0% of cases floating DVT, while no cases of embolism were detected in occluding DVT ( p < 0.01). Groups of patients with the length of the floating part of the thrombus up to 5 cm were analyzed. Anticoagulant therapy was used in 42 cases; thrombectomy was performed in 52 cases. There was no case of pulmonary embolism when treated with both conservative and surgical methods. Conclusions Based on our research, it can be stated that floating thrombosis of deep veins of proximal venous segments is a type of thrombosis that has an increased risk of thromboembolic complications when the length of the floating part is 5 cm or more.
The impact of metformin on survival in diabetes patients with operable colorectal cancer: A nationwide retrospective cohort study
Authors: Chu Ping-Teng , Chuang Tzu-Jung , Huang Shu-Hung , Wu Tung-Ho , Huang Wei-Chun , Wang Jui-Ho 
Published: April 2023

Objective To investigate the impact of metformin on survival of diabetic patients following surgery for colorectal cancer (CRC). Methods This was a retrospective cohort study. From Taiwan’s population-based National Health Insurance Research Database (NHIRD) we identified 12,512 patients with CRC and type II diabetes who underwent curative surgery between 2000 and 2012. Of these, 6222 patients were included in a matched cohort. Using Cox regression models with time-dependent covariates we examined the impact of metformin on survival. Results Average duration of follow-up was 49 and 54 months for metformin users and non-users, respectively. Cox proportional hazard model showed that metformin was associated with 5-year overall survival benefit (Hazard ratio, 0.23 [95% CI, 0.20–0.26]) and inverse association with risk of liver metastasis (Hazard ratio, 0.79 [95% CI, 0.68–0.93]). Conclusions Metformin was associated with a survival benefit in diabetic patients with CRC following surgery, and an inverse association with risk of liver metastases suggesting a potential anti-tumorigenic effect.
Association of Patient-Reported Anxiety and Pain After Alveolar Bone Grafting
Authors: Mirzaie Sarah , Oberoi Michelle K. , Huang Kelly X. , Caprini Rachel M. , Malapati Sri Harshini , Dejam Dillon , Bedar Meiwand , Cronin Brendan J. , Khetpal Sumun , Lee Justine C. 
Published: April 2023

Objective To evaluate the role of psychosocial well-being on perioperative pain and opioid use among patients with cleft lip and palate (CLP) undergoing alveolar bone grafting (ABG). Design Retrospective review. Setting Tertiary level craniofacial clinic. Participants 34 patients with CLP (median age: 11.7 years), including 25 (73.5%) unilateral CLP and 9 (26.5%) bilateral CLP, who underwent ABG from 2015 to 2022. Interventions ABG using iliac crest bone graft. Patients were prospectively administered four patient-reported psychosocial instruments from the Patient-Reported Outcomes Measurement Information System. Main Outcome Measures Perioperative opioid use in morphine equivalent dosage/kilogram, patient-reported pain scores, and length of hospital stay after ABG. Results Patient-reported anxiety (r = 0.41, p = 0.02) and depressive symptoms (r = 0.35, p = 0.04) correlated to higher perioperative opioid usage. Multivariable regression models including psychosocial scores, total acetaminophen usage, length of surgery, and other simultaneous surgeries were developed for total opioid usage, patient-reported pain, and length of hospital stay. Patient-reported anxiety was independently predictive of higher perioperative opioid use (β=0.36, p = 0.01) and higher pain scores (β=0.39, p = 0.02), but not length of hospital stay. Conclusions We identified an association for patient-reported anxiety and perioperative opioid use and pain in a CLP cohort undergoing ABG. Future considerations in preoperative patient and family consultation may be indicated in patients self-reporting higher anxiety in an effort to minimize perioperative opioid usage.
Brain Tumor Radiogenomic Classification of O6-Methylguanine-DNA Methyltransferase Promoter Methylation in Malignant Gliomas-Based Transfer Learning
Authors: Sakly Houneida , Said Mourad , Seekins Jayne , Guetari Ramzi , Kraiem Naoufel , Marzougui Mehrez 
Published: April 2023

Artificial Intelligence (AI) is the subject of a challenge and attention in the field of oncology and raises many promises for preventive diagnosis, but also fears, some of which are based on highly speculative visions for the classification and detection of tumors. A brain tumor that is malignant is a life-threatening disorder. Glioblastoma is the most prevalent kind of adult brain cancer and the 1 with the poorest prognosis, with a median survival time of less than a year. The presence of O6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation, a particular genetic sequence seen in tumors, has been proven to be a positive prognostic indicator and a significant predictor of recurrence. This strong revival of interest in AI is modeled in particular to major technological advances which have significantly increased the performance of the predicted model for medical decision support. Establishing reliable forecasts remains a significant challenge for electronic health records (EHRs). By enhancing clinical practice, precision medicine promises to improve healthcare delivery. The goal is to produce improved prognosis, diagnosis, and therapy through evidence-based sub stratification of patients, transforming established clinical pathways to optimize care for each patient’s individual requirements. The abundance of today’s healthcare data, dubbed “big data,” provides great resources for new knowledge discovery, potentially advancing precision treatment. The latter necessitates multidisciplinary initiatives that will use the knowledge, skills, and medical data of newly established organizations with diverse backgrounds and expertise. The aim of this paper is to use magnetic resonance imaging (MRI) images to train and evaluate your model to detect the presence of MGMT promoter methylation in this competition to predict the genetic subtype of glioblastoma based transfer learning. Our objective is to emphasize the basic problems in the developing disciplines of radiomics and radiogenomics, as well as to illustrate the computational challenges from the perspective of big data analytics.
Computed Tomography Neurography for Visualization of the In Vivo Nervous System: A Proof of Concept
Authors: McCarthy James E. , Serkova Natalie J. 
Published: April 2023

Background: The human peripheral nervous system embodies anatomical, physiologic, and diagnostic perplexities that remain unexplained. Yet in the course of human history, there are no mechanisms, such as computed tomography (CT) or radiography, by which to image the peripheral nervous system in vivo using a contrast agent that is identified by ionizing radiation, which would aid in surgical navigation, diagnostic radiology, and basic science thereof. Methods: A novel class of contrast was created by linking iodine to lidocaine. The radiodensity of 0.5% experimental contrast molecule was compared with a control of 1% lidocaine by placing 1.5-mL aliquots of each liquid into centrifuge tubes and performing micro–computed tomography (micro-CT) synchronously under identical settings. Physiologic binding to the sciatic nerve was evaluated by injecting 10 mg of the experimental contrast and 10 mg of the control into the contralateral sciatic nerve, and documenting loss of hindlimb function and recovery. In vivo visualization of the sciatic nerve was evaluated by injecting 10 mg of experimental contrast or control into either sciatic nerve and imaging the hindlimbs under identical conditions using micro-CT. Results: The mean Hounsfield unit of the contrast was 56.09 compared with −0.48 for control (116-fold increase, P = .0001). Hindlimb paresis revealed similar degree of paresis, baseline recovery, and time to recovery. In vivo enhancement between the contralateral sciatic nerves was similar. Conclusion: Iodinated lidocaine offers a viable mechanism for in vivo peripheral nerve imaging using CT; however, it requires modification to improve in vivo radiodensity.