bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Online Mammography Database with Biopsy Confirmed Types
Authors: Cai Hongmin , Wang Jinhua , Dan Tingting , Li Jiao , Fan Zhihao , Yi Weiting , Cui Chunyan , Jiang Xinhua , Li Li 
Published: March 2023

AbstractBreast carcinoma is the second largest cancer in the world among women. Early detection of breast cancer has been shown to increase the survival rate, thereby significantly increasing patients’ lifespan. Mammography, a noninvasive imaging tool with low cost, is widely used to diagnose breast disease at an early stage due to its high sensitivity. Although some public mammography datasets are useful, there is still a lack of open access datasets that expand beyond the white population as well as missing biopsy confirmation or with unknown molecular subtypes. To fill this gap, we build a database containing two online breast mammographies. The dataset named by Chinese Mammography Database (CMMD) contains 3712 mammographies involved 1775 patients, which is divided into two branches. The first dataset CMMD1 contains 1026 cases (2214 mammographies) with biopsy confirmed type of benign or malignant tumors. The second dataset CMMD2 includes 1498 mammographies for 749 patients with known molecular subtypes. Our database is constructed to enrich the diversity of mammography data and promote the development of relevant fields.
Blue-light background impairs visual exogenous attention shift
Authors: Yang Chien-Chun , Tsujimura Sei-ichi , Yeh Su-Ling 
Published: March 2023

AbstractPrevious research into the effects of blue light on visual-spatial attention has yielded mixed results due to a lack of properly controlling critical factors like S-cone stimulation, ipRGCs stimulation, and color. We adopted the clock paradigm and systematically manipulated these factors to see how blue light impacts the speed of exogenous and endogenous attention shifts. Experiments 1 and 2 revealed that, relative to the control light, exposure to the blue-light background decreased the speed of exogenous (but not endogenous) attention shift to external stimuli. To further clarify the contribution(s) of blue-light sensitive photoreceptors (i.e., S-cone and ipRGCs), we used a multi-primary system that could manipulate the stimulation of a single type of photoreceptor without changing the stimulation of other photoreceptors (i.e., the silent substitution method). Experiments 3 and 4 revealed that stimulation of S-cones and ipRGCs did not contribute to the impairment of exogenous attention shift. Our findings suggest that associations with blue colors, such as the concept of blue light hazard, cause exogenous attention shift impairment. Some of the previously documented blue-light effects on cognitive performances need to be reevaluated and reconsidered in light of our findings.
Subsistence of early anatomically modern humans in Europe as evidenced in the Protoaurignacian occupations of Fumane Cave, Italy
Authors: Marín-Arroyo Ana B. , Terlato Gabriele , Vidal-Cordasco Marco , Peresani Marco 
Published: March 2023

AbstractDocumenting the subsistence strategies developed by early modern humans is relevant for understanding the success of their dispersal throughout Eurasia. Today, we know that there was not a single colonization event and that the process was progressive while coping with the MIS3 abrupt climatic oscillations. Modern humans expanded into the continent by adapting to different topographic situations and by exploiting resources in diverse ecological niches. The northern part of Italy is one of the first European regions where early modern humans are documented. Here, we present the subsistence regimen adopted by the Protoaurignacian groups in two different levels in Fumane Cave based on archaeozoological data. New radiocarbon dates confirm an overlap between Uluzzian and Protoaurignacian occupations, around 42 and 41,000 cal BP, and reveal that modern humans occupied the cave from GI10 to GS9, the last level coinciding with the Heinrich Event 4. The data indicate seasonal site occupations during late spring/summer and that prey exploitation was focused mostly on ibex and chamois, killed in nearby areas. The whole faunal assemblage suggests the presence of early modern humans in a cold environment with mostly open landscapes and patchy woodlands. The estimation of net primary productivity (NPP) in Fumane, compared with other contemporaneous Italian sites, reflects how the NPP fluctuations in the Prealpine area, where Fumane is located, affected the biotic resources in contrast to known Mediterranean sites. From a pan-European perspective, the spatiotemporal fluctuation of the NPP versus the subsistence strategies adopted by Protoaurignacian groups in the continent supports rapid Homo sapiens dispersal and resilience in a mosaic of environments that were affected by significant climate changes.
Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib
Authors: Till Kathleen J. , Abdullah Mariah , Alnassfan Tahera , Janet Gallardo Zapata , Marks Thomas , Coma Silvia , Weaver David T. , Pachter Jonathan A. , Pettitt Andrew R. , Slupsky Joseph R. 
Published: March 2023

AbstractMantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma that is incurable with existing therapies, and therefore presents a significant unmet clinical need. The ability of this disease to overcome therapy, including those that target the B cell receptor pathway which has a pathogenic role in MCL, highlights the need to develop new treatment strategies. Herein, we demonstrate that a distinguishing feature of lymph node resident MCL cells is the expression of phosphatidylinositol 3-kinase γ (PI3Kγ), a PI3K isoform that is not highly expressed in other B cells or B-cell malignancies. By exploring the role of PI3K in MCL using different PI3K isoform inhibitors, we provide evidence that duvelisib, a dual PI3Kδ/γ inhibitor, has a greater effect than PI3Kδ- and PI3Kγ-selective inhibitors in blocking the proliferation of primary MCL cells and MCL cell lines, and in inhibiting tumour growth in a mouse xenograft model. In addition, we demonstrated that PI3Kδ/γ signalling is critical for migration of primary MCL cells and cell lines. Our data indicates that aberrant expression of PI3Kγ is a critical feature of MCL pathogenesis. Thus, we suggest that the dual PI3Kδ/γ duvelisib would be effective for the treatment of mantle cell lymphoma.
Smoking-induced subgingival dysbiosis precedes clinical signs of periodontal disease
Authors: Tamashiro Ryan , Strange Leah , Schnackenberg Kristin , Santos Janelle , Gadalla Hana , Zhao Lisa , Li Eric C. , Hill Emilie , Hill Brett , Sidhu Gurjit S. , Kirst Mariana , Walker Clay , Wang Gary P. 
Published: March 2023

AbstractSmoking accelerates periodontal disease and alters the subgingival microbiome. However, the relationship between smoking-associated subgingival dysbiosis and progression of periodontal disease is not well understood. Here, we sampled 233 subgingival sites longitudinally from 8 smokers and 9 non-smokers over 6–12 months, analyzing 804 subgingival plaque samples using 16 rRNA sequencing. At equal probing depths, the microbial richness and diversity of the subgingival microbiome was higher in smokers compared to non-smokers, but these differences decreased as probing depths increased. The overall subgingival microbiome of smokers differed significantly from non-smokers at equal probing depths, which was characterized by colonization of novel minority microbes and a shift in abundant members of the microbiome to resemble periodontally diseased communities enriched with pathogenic bacteria. Temporal analysis showed that microbiome in shallow sites were less stable than deeper sites, but temporal stability of the microbiome was not significantly affected by smoking status or scaling and root planing. We identified 7 taxa—Olsenella sp., Streptococcus cristatus, Streptococcus pneumoniae, Streptococcus parasanguinis, Prevotella sp., Alloprevotella sp., and a Bacteroidales sp. that were significantly associated with progression of periodontal disease. Taken together, these results suggest that subgingival dysbiosis in smokers precedes clinical signs of periodontal disease, and support the hypothesis that smoking accelerates subgingival dysbiosis to facilitate periodontal disease progression.
Emotion recognition based on group phase locking value using convolutional neural network
Authors: Cui Gaochao , Li Xueyuan , Touyama Hideaki 
Published: March 2023

AbstractElectroencephalography (EEG)-based emotion recognition is an important technology for human–computer interactions. In the field of neuromarketing, emotion recognition based on group EEG can be used to analyze the emotional states of multiple users. Previous emotion recognition experiments have been based on individual EEGs; therefore, it is difficult to use them for estimating the emotional states of multiple users. The purpose of this study is to find a data processing method that can improve the efficiency of emotion recognition. In this study, the DEAP dataset was used, which comprises EEG signals of 32 participants that were recorded as they watched 40 videos with different emotional themes. This study compared emotion recognition accuracy based on individual and group EEGs using the proposed convolutional neural network model. Based on this study, we can see that the differences of phase locking value (PLV) exist in different EEG frequency bands when subjects are in different emotional states. The results showed that an emotion recognition accuracy of up to 85% can be obtained for group EEG data by using the proposed model. It means that using group EEG data can effectively improve the efficiency of emotion recognition. Moreover, the significant emotion recognition accuracy for multiple users achieved in this study can contribute to research on handling group human emotional states.
Hydrological controls on base metal precipitation and zoning at the porphyry-epithermal transition constrained by numerical modeling
Authors: Stoltnow Malte , Weis Philipp , Korges Maximilian 
Published: March 2023

AbstractOre precipitation in porphyry copper systems is generally characterized by metal zoning (Cu–Mo to Zn–Pb–Ag), which is suggested to be variably related to solubility decreases during fluid cooling, fluid-rock interactions, partitioning during fluid phase separation and mixing with external fluids. Here, we present new advances of a numerical process model by considering published constraints on the temperature- and salinity-dependent solubility of Cu, Pb and Zn in the ore fluid. We quantitatively investigate the roles of vapor-brine separation, halite saturation, initial metal contents, fluid mixing and remobilization as first-order controls of the physical hydrology on ore formation. The results show that the magmatic vapor and brine phases ascend with different residence times but as miscible fluid mixtures, with salinity increases generating metal-undersaturated bulk fluids. The release rates of magmatic fluids affect the location of the thermohaline fronts, leading to contrasting mechanisms for ore precipitation: higher rates result in halite saturation without significant metal zoning, lower rates produce zoned ore shells due to mixing with meteoric water. Varying metal contents can affect the order of the final metal precipitation sequence. Redissolution of precipitated metals results in zoned ore shell patterns in more peripheral locations and also decouples halite saturation from ore precipitation.
Release of sterile Aedes aegypti mosquitoes: chilling effect on mass-reared males survival and escape ability and on irradiated males sexual competitiveness
Authors: Sánchez-Aldana-Sánchez Génesis Alejandra , Liedo Pablo , Bond J. Guillermo , Dor Ariane 
Published: March 2023

AbstractIn the sterile insect technique, it is important to measure the impact of mass-rearing and handling of sterile males to allow a successful control of the target wild population. This study evaluates the effect of pre-release chilling on the survival, escape ability, and sexual competitiveness of male Aedes aegypti. To determine survival and escape ability, mosquitoes were chilled at 4 °C using four different treatments of either one exposure (25 min) or two consecutive exposures (25 + 25 min, 25 + 50 min, 25 + 100 min). For sexual competitiveness, two different treatments were evaluated, chilling for 25 min once and twice. Results showed that the longest exposure to chilling caused a significant reduction of survival time, from 67 to 54 days. Escape ability was reduced by the first chilling from 25 to 7% and with the second chilling, it was reduced from 30 to 24% in the control to 4.9, 2.0 and 0.5% for 25, 50 and 100 min, respectively. Sexual competitiveness index was reduced from 1.16 in the control, to 0.32 and − 0.11 for treatments involving one and two chilling periods, respectively. It is recommended to increase the chilling temperature and reduce the exposure time to reduce the harmful effects on sterile males.
EHR foundation models improve robustness in the presence of temporal distribution shift
Authors: Guo Lin Lawrence , Steinberg Ethan , Fleming Scott Lanyon , Posada Jose , Lemmon Joshua , Pfohl Stephen R. , Shah Nigam , Fries Jason , Sung Lillian 
Published: March 2023

AbstractTemporal distribution shift negatively impacts the performance of clinical prediction models over time. Pretraining foundation models using self-supervised learning on electronic health records (EHR) may be effective in acquiring informative global patterns that can improve the robustness of task-specific models. The objective was to evaluate the utility of EHR foundation models in improving the in-distribution (ID) and out-of-distribution (OOD) performance of clinical prediction models. Transformer- and gated recurrent unit-based foundation models were pretrained on EHR of up to 1.8 M patients (382 M coded events) collected within pre-determined year groups (e.g., 2009–2012) and were subsequently used to construct patient representations for patients admitted to inpatient units. These representations were used to train logistic regression models to predict hospital mortality, long length of stay, 30-day readmission, and ICU admission. We compared our EHR foundation models with baseline logistic regression models learned on count-based representations (count-LR) in ID and OOD year groups. Performance was measured using area-under-the-receiver-operating-characteristic curve (AUROC), area-under-the-precision-recall curve, and absolute calibration error. Both transformer and recurrent-based foundation models generally showed better ID and OOD discrimination relative to count-LR and often exhibited less decay in tasks where there is observable degradation of discrimination performance (average AUROC decay of 3% for transformer-based foundation model vs. 7% for count-LR after 5–9 years). In addition, the performance and robustness of transformer-based foundation models continued to improve as pretraining set size increased. These results suggest that pretraining EHR foundation models at scale is a useful approach for developing clinical prediction models that perform well in the presence of temporal distribution shift.
The ratio of TAPSE to PASP predicts prognosis in lung transplant candidates with pulmonary arterial hypertension
Authors: Ishii Satoshi , Minatsuki Shun , Hatano Masaru , Saito Akihito , Yagi Hiroki , Shimbo Mai , Soma Katsura , Fujiwara Takayuki , Itoh Hidetaka , Konoeda Chihiro , Sato Masaaki , Takeda Norifumi , Daimon Masao , Nakajima Jun , Komuro Issei 
Published: March 2023

AbstractLung transplantation (LT) is the only option for patients with pulmonary arterial hypertension (PAH) refractory to maximal medical therapy. However, some patients referred for LT could survive without LT, and its determinants remain unclear. This study aimed to elucidate prognostic factors of severe PAH at the referral time. We retrospectively analyzed 34 patients referred for LT evaluation. The primary outcome was a composite of death or LT. Over a median follow-up period of 2.56 years, eight patients received LT and eight died. Compared with LT-free survival group, pulmonary arterial systolic pressure (PASP) was higher (p = 0.042), and the ratio of tricuspid annular plane systolic excursion (TAPSE) to PASP (TAPSE/PASP) was lower (p = 0.01) in LT or death group. In receiver operating characteristic analysis, the area under the curve was 0.759 (95% confidence interval 0.589–0.929) for TAPSE/PASP to predict primary outcome, and the optimal cut-off value was 0.30 mm/mmHg (sensitivity 0.875 and specificity 0.667). In a multivariate analysis, TAPSE/PASP was independently associated with death or LT. Kaplan–Meier analysis showed a better LT-free survival in patients with TAPSE/PASP ≧0.30 mm/mmHg than in those with < 0.30 mm/mmHg (p = 0.001). Low-level TAPSE/PASP could be a poor prognostic factor in PAH patients referred for LT evaluation.
A Pleistocene origin of the strandflat coastal platform in southwestern Scandinavia
Authors: Fossen Haakon 
Published: March 2023

AbstractAn impressively extensive shore platform, the strandflat, is cut 20–50 km into hard crystalline bedrock along most of the Norwegian coastline. Its age and origin have been debated for more than a century, including a model that it represents a weathered, buried and re-exposed Triassic surface. Resolving this issue requires integrated examination of the coastal area together with the offshore Mesozoic rift margin. Here I combine new 3D broadband seismic, bathymetric, and onshore elevation data along coastal West Norway and find that the near-horizontal strandflat postdates both the west-sloping onshore “paleic” surface and the offshore Jurassic denudation surface. It also postdates tilted North Sea Neogene sediments. Consistent with low-temperature thermochronologic data, this shows that the strandflat is a Pleistocene geomorphic feature formed through periods of varying climatic conditions, facilitated by preexisting fault and fracture zones. It is not part of an inherited Mesozoic landscape.
Punicalagin protects against impaired skeletal muscle function in high-fat-diet-induced obese mice by regulating TET2
Authors: Meng Xiangyuan , Tian Chunyan , Xie Chenqi , Zhang Hao , Wang Haoyu , Zhang Mai , Lu Zhenquan , Li Duo , Chen Lei , Gao Tianlin 
Published: March 2023

Punicalagin supplementation protects against obesity-induced impairment of the skeletal muscle function via regulating the protein stability of TET2 and the enzymatic activity of TET2 demethylation.
C3N2: the missing part of highly stable porous graphitic carbon nitride semiconductors
Authors: Cai Xinyong , Chen Jiao , Wang Hongyan , Ni Yuxiang , Chen Yuanzheng , King R. Bruce 
Published: March 2023

With two suitable organic units (TAPA and HADQ), H-C3N2 and T-C3N2 are designed and proposed based on the high possibility for experimental realization. They show different structural features and exceptional optoelectronic properties.
Detection of emotional and behavioural changes after traumatic brain injury: A comprehensive survey
Authors: Vutakuri Neha 
Published: March 2023

AbstractTraumatic brain injury (TBI) can affect normal brain function and may be caused by a vehicle accident, falling, and so on. The purpose of this survey is to provide clear knowledge of TBI, the causes of TBI, the impacts of TBI, and the role of family members and friends in recovery. TBI affects the daily life of the patients, both physically and mentally. After TBI, the patients may experience many emotional and behavioural changes because of a lack of certain brain functions. These changes affect their personal and social relationships. On the other hand, these changes depend on the severity of the TBI (i.e. mild, moderate, or severe), which is measured using the Glasgow coma score. Generally, three processes are used for emotion recognition: preprocessing, feature extraction, and emotion recognition. Preprocessing is performed for landmark detection and pose normalisation, which improves the performance of emotion detection. Feature extraction and emotion recognition are performed by various deep learning techniques, such as convolution neural networks and long short‐term memory. These techniques recognise the behavioural and emotional changes (depression, anxiety, anger, personality changes etc.) of TBI patients using facial expressions. Family members and friends play an important role in TBI patients' recovery, the extent of which is based on the severity of the TBI. The care of family members and friends leads to quick recovery and rehabilitation of patients from TBI. Finally, testing is performed using Computed Tomography images, Magnetic Resonance Imaging images, Electroencephalography signals, and patient demographics, which together show that the deep learning methods achieve better performance in terms of accuracy, precision, recall, and F‐measure in recognising emotional and behavioural changes after TBI. The authors conclude with a summary of the future of emotional and behavioural change prediction methods for TBI patients.
Design of 60 GHz millimeter‐wave SIW antenna for 5G WLAN/WPAN applications
Authors: Al Soufy Khaled A. , Al‐ashwal Nagi H. , Swillam M. A. , Al‐Kamali Faisal S. , D'Amours Claude , Marish Essa M. , Alnajjar Ali N. 
Published: March 2023

AbstractBroadband millimeter Wave (mmWave) transmission at the 60 GHz band is a great prospect to meet the demanding high data rate requirements of future wireless personal area network (WPAN) and wireless local area network (WLAN) 5G networks. This paper proposes a single layer H‐plane sectoral horn mmWave antenna at 60 GHz using substrate integrated waveguide (SIW) technology for the future high‐speed short range WPAN and WLAN networks. The benefits of the proposed antenna are high gain, low cost, small size, and ease of integration with other planar circuits. The proposed SIW horn is constructed with RT/duroid 5880 substrate, which has a relative permittivity and loss tangent with a thickness of 0.508 mm. The novelty of this work is; a wider bandwidth is achieved by adding striplines at the horn aperture to match the antenna with air and to increase the antenna operating bandwidth. In addition, the antenna gain is improved by adding a dielectric lens with the striplines at the radiating end. During these steps, the antenna parameters are tuned and optimized to achieve the best results as compared to related previous studies. The proposed antenna's performance is analyzed in terms of gain, return loss (S11) and radiation pattern at a frequency of 60 GHz. Simulation results are carried out by using industry standard software, Computer Simulation Technology (CST) microwave studio. The designed antenna achieves a peak gain of 13 dB and impedance bandwidth when , 8.6 GHz (13.688%) for the reflection coefficient of . The results show that the proposed antenna achieves stable tunable 60 GHz frequency performance, which makes it feasible to deploy in WLAN/WPAN operating in mmWave bands.