bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geo-climatic variability and adult asthma hospitalization in Fars, Southwest Iran
Authors: Kanannejad Zahra , Shokri Yousef , Alyasin Soheila , Ghatee Mohammad Amin , Soleimanian Saeede 
Published: April 2023

Asthma is a chronic respiratory disease resulting from a complex interaction between genetic and environmental factors. Many environmental factors have been associated with incidence or prevalence of asthma although there is still limited knowledge of major environmental causes of asthma in the general population. This study, for the first time, investigated the effects of climatic and geographical variability on asthma hospitalization among an adult population living in Fars province, southwest Iran. During the study period, the home addresses of patients hospitalized with acute asthma from 2016 to 2019 were mapped. The effects of geo-climatic factors including temperature, rainfall, humidity, evaporation, number of rainy and frosty days, slope, and land covers were assessed on adult asthma hospitalization by Geographical Information System (GIS). Data were analyzed using univariate and multivariate binary logistic regression. A total of 349 patients were recruited, including 157 (44.98%) males and 192 (55%) females. The mean age was 57.77 ± 18.84 years, ranging from 19 to 98 years. Asthmatic patients came from a total of 82 points including villages, towns, and cities. In the univariate analysis, urban setting (OR = 13) and Mean Annual Rainy Days (OR = 1.03) were identified as the factors associated with increased asthma hospitalization, while Mean Annual Temperature (MAT) (OR = 0.927), MinMAT (OR = 0.933), MaxMAT (OR = 0.925), Mean Annual Evaporation (MAE) (OR = 0.999), and slope (OR = 0.925) negatively affected asthma hospitalization. Urban setting was considered the only significant factor in multivariate analysis (OR = 11.026). The major risk zones for adulthood acute asthma in southwest Iran were urban settings and areas with higher numbers of rainy days, lower temperatures, and evaporation at lower slopes.
Gene polymorphisms of inflammatory factors in liver cirrhosis
Authors: Xiao Sailan , Pan Xiongfeng , Huang Xun , Liu Yamin , Wen Shi Wu , Liu Aizhong 
Published: April 2023

Introduction: Studies on the association between gene polymorphisms of various inflammatory factors and liver cirrhosis have been inconsistent. The purpose of this study was to comprehensively summarize the available evidence on the association between gene polymorphisms of inflammatory factors and liver cirrhosis through a systematic review.Methods: We searched databases of PubMed, EMBASE, Web of Science, and the Cochrane Library for relevant articles published from building databases to 25 September 2022. A systematic review and meta‐analysis were performed to investigate the association between gene polymorphisms of various inflammatory factors and liver cirrhosis. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of association.Results: A total of 43 articles were included in the systematic review and of them, 22 articles were included in the meta‐analysis. The gene polymorphisms of IL-10–1082 GA + AA vs. GG (OR = 1.43, 95% CI = 1.12–1.83), IL-10–1082 AA vs. GG (OR = 2.03, 95% CI = 1.36–3.02), IL-18 -137 GG vs. CC (OR = 3.84, 95% CI = 1.29–11.40), TGF-β1 -509 T vs. C (OR = 2.52, 95% CI = 1.42–4.48), and IFN-γ +874 T vs. A (OR = 1.98, 95% CI = 1.32–2.98) were associated with liver cirrhosis significantly and no association was observed in other gene polymorphisms included in the meta‐analysis. The review of inflammatory factors gene polymorphisms that were only reported by a single study indicated 19 gene polymorphisms were risk factors and 4 gene polymorphisms were protective factors for liver cirrhosis, while the association between other 27 gene polymorphisms and liver cirrhosis were not statistically significant.Discussion: This study suggests that IL-10 -1082G/A, IL-18 -137G/C, TGF-β1 -509T/C, and IFN-γ +874T/A were potentially associated with the risk of liver cirrhosis susceptibility. These findings may provide comprehensive evidence for genetic susceptibility and immunogenetic pathology of liver cirrhosis.
Dependence of microstructural evolution on the geometric structure for serviced DZ125 turbine blades
Authors: Xie Yadan , Zhao Jianjiang , Fu Haoran , Wei Hua 
Published: April 2023

The turbine blades were directionally solidified by a high-rate solidification process by the Bridgman technique using directional solidified Ni-based master superalloy DZ125 and operated on the engine bench with a high-temperature gas environment of more than 1500 °C from combustor and high-speed rotation of more than 13500 rpm for 400 h. A service-environment-based model was put forward to simulate the distribution of temperature and stress on the DZ125 blade in service. It was found that the distribution of temperature and stress on the serviced DZ125 blade was closely related to its geometric structure. The microstructural evolution of the serviced DZ125 blade was analyzed and the variations of microstructures with temperature and stress were investigated by using a scanning electron microscope. The results revealed that the evolution process of microstructures on the serviced DZ125 blade was different from that of the standard sample tested at constant temperature and uniaxial tensile stress. The reason for this discrepancy was explored using a combination of finite-element calculation and diffusion coefficient calculation.
Ginsenoside Rg1 can reverse fatigue behavior in CFS rats by regulating EGFR and affecting Taurine and Mannose 6-phosphate metabolism
Authors: Lei Chaofang , Chen Jiaxu , Huang Zhen , Men Yinian , Qian Yue , Yu Mingzhi , Xu Xinyi , Li Lin , Zhao Xin , Jiang Youming , Liu Yueyun 
Published: April 2023

Background: Chronic fatigue syndrome (CFS) is characterized by significant and persistent fatigue. Ginseng is a traditional anti-fatigue Chinese medicine with a long history in Asia, as demonstrated by clinical and experimental studies. Ginsenoside Rg1 is mainly derived from ginseng, and its anti-fatigue metabolic mechanism has not been thoroughly explored.Methods: We performed non-targeted metabolomics of rat serum using LC-MS and multivariate data analysis to identify potential biomarkers and metabolic pathways. In addition, we implemented network pharmacological analysis to reveal the potential target of ginsenoside Rg1 in CFS rats. The expression levels of target proteins were measured by PCR and Western blotting.Results: Metabolomics analysis confirmed metabolic disorders in the serum of CFS rats. Ginsenoside Rg1 can regulate metabolic pathways to reverse metabolic biases in CFS rats. We found a total of 34 biomarkers, including key markers Taurine and Mannose 6-phosphate. AKT1, VEGFA and EGFR were identified as anti-fatigue targets of ginsenoside Rg1 using network pharmacological analysis. Finally, biological analysis showed that ginsenoside Rg1 was able to down-regulate the expression of EGFR.Conclusion: Our results suggest ginsenoside Rg1 has an anti-fatigue effect, impacting the metabolism of Taurine and Mannose 6-phosphate through EGFR regulation. This demonstrates ginsenoside Rg1 is a promising alternative treatment for patients presenting with chronic fatigue syndrome.
Novel Approach for a Controlled Delivery of Essential Oils during Long-Term Maize Storage: Clove Bud and Pennyroyal Oils Efficacy to Control Sitophilus zeamais, Reducing Grain Damage and Post-Harvest Losses
Authors: Sousa Pedro A. S. , Neto Joana , Barbosa Joana V. , Peres Joana , Magro Ana , Barros Graça , Sousa José M. , Magalhães Fernão D. , Mexia António , Aguiar Ana A. R. M. , Bastos Margarida M. S. M. 
Published: April 2023

Maize grains represent a significant contribution for assuring food safety all over the globe. Sitophilus zeamais (Motschulsky) (Coleoptera: Curculionidae), also known as the maize weevil, is one of the most destructive pests in stored maize, causing qualitative and quantitative losses. To control S. zeamais populations in maize storage sites, synthetical chemical insecticides are applied. However, these are often used wastefully, have environmental implications, and can induce the development of resistant populations. In this work, the insecticidal and grain protecting efficacy of an innovative macro-capsule delivery device, loaded with essential oils from Clove bud and Pennyroyal, as well as their combined solutions, was tested against naturally S. zeamais-infested maize grains. The blend of both compounds incorporated in a controlled release device reduced losses by more than 45% over a long storage period of twenty weeks, diminishing the survivability of maize weevils by over 90%. The usage of the blend at a concentration of 370 μL⋅Lair−1 with an antioxidant showed the best results, however, by halving the concentration (185 μL⋅Lair−1), a significant control of S. zeamais populations was still achieved.
Secondary Metabolites Profiling, Antimicrobial and Cytotoxic Properties of Commiphora gileadensis L. Leaves, Seeds, Callus, and Cell Suspension Extracts
Authors: Al-Abdallat Ayed M. , Adayileh Batool K. , Sawwan Jamal S. , Shibli Rida , Al-Qudah Tamara S. , Abu-Irmaileh Bashaer , Albdaiwi Randa N. , Almaliti Jehad , Bustanji Yasser 
Published: April 2023

Commiphora gileadensis L. is an important endangered medicinal plant that belongs to the family Burseraceae. In this study, C. gileadensis callus culture was established successfully using mature leaves as explants cultured on Murashige and Skoog (MS) media supplemented with 24.50 μM of indole butyric acid (IBA) and 2.22 μM 6-Benzylaminopurine (BAP) (callus induction media). The obtained callus was maintained on MS medium supplemented with 16.11 μM naphthalene acetic acid (NAA) in combination with 6.66 μM BAP, which resulted in a substantial increase in callus fresh and dry weights. The cell suspension culture was established successfully using liquid callus induction media supplemented with 3.0 mg·L−1 proline. Thereafter, the chemical constituents of different C. gileadensis methanolic extracts (callus, cell suspension, leaves, and seeds) were profiled, and their cytotoxic and antimicrobial properties were investigated. The LC-MS GNPS analyses were applied for chemical profiling of the methanolic plant extracts, and several natural products were identified, including flavonols, flavanones, and flavonoids glycosides, with two unusual families that included puromycin, 10-hydroxycamptothecin, and justicidin B. The methanolic extracts have shown selective antimicrobial and cytotoxic properties against different microbes and cancer cell lines. For instance, leaf extract showed the highest zone of inhibition for Staphylococcus aureus, while cell suspension culture was effective against Staphylococcus epidermidis and Staphylococcus aureus. All extracts showed selective activity against A549 cell lines for the cytotoxicity assay, while the leaf extract had a broad cytotoxic effect against all tested cell lines. This study revealed that C. gileadensis callus and cell suspension cultures can be employed to increase the in vitro formation of biologically active compounds that may have cytotoxicity and antibacterial action against different cancer cell lines and bacterial species. Further studies are required to isolate and identify such constituents that corroborate the observed activities.
Numerical Approximation of a Time-Fractional Modified Equal-Width Wave Model by Using the B-Spline Weighted Residual Method
Authors: AL-saedi Akeel A. , Rashidinia Jalil 
Published: April 2023

Fractional calculus (FC) is an important mathematical tool in modeling many dynamical processes. Therefore, some analytical and numerical methods have been proposed, namely, those based on symmetry and spline schemes. This paper proposed a numerical approach for finding the solution to the time-fractional modified equal-width wave (TFMEW) equation. The fractional derivative is described in the Caputo sense. Indeed, the B-spline Galerkin scheme combined with functions with different weights was employed to discretize TFMEW. The L2 and L∞ error norm values and the three invariants I1, I2, and I3 of the numerical example were calculated and tabulated. A comparison of these errors and invariants was provided to confirm the efficiency and accuracy of the proposed method.
evaluación operativa anual y su impacto en la gestión estratégica de las organizaciones. Caso Universidad San Gregorio de Portoviejo
Authors: Valdiviezo Pinargote Gloria Cecilia , Bravo Rosillo Gissela 
Published: April 2023

La evaluación operativa anual es un aspecto fundamental para medir la gestión periódica de los objetivos, metas, programas, proyectos y acciones que se vinculan a la gestión estratégica; constituye, además, un proceso relevante para la mejora continua y medición de los estándares de eficiencia y eficacia en las organizaciones. El objetivo de esta investigación es determinar el impacto de la evaluación operativa anual durante el periodo 2015-2019 en la gestión estratégica de la Universidad San Gregorio de Portoviejo. Se utlizó el método cuantitativo y cualitativo, explicativo y correlacional. A través de los resultados se destacó la consecución de proyectos entre los tiempos programados y la inversión realizada, el autofinanciamiento para la ejecución de los proyectos académicos, investigación y vinculación y la formación como un aspecto relevante para el seguimiento y ejecución de proyectos de manera efectiva. Se concluyó que la sinergia y articulación entre las áreas permite una alineación a las diferentes estrategias que representan los medios para alcanzar los objetivos estratégicos; asimismo, se puntualiza la necesidad de adoptar medidas preventivas y correctivas para mejorar la gestión estratégica con el involucramiento de los actores claves.
Amino Acids and Their Derivatives in Oncology: A Review
Authors: Нефёдов Л.И. 
Published: April 2023

Наблюдаемые при злокачественном росте особенности изменения аминокислотного состава биологических жидкостей и тканей специфически характеризуют онкологическую патологию. В значительной степени они формируются в результате метаболической конкуренции за общие субстраты, необходимые для обеспечения пластических и энергетических потребностей опухоли и других тканей организма. Направленная коррекция метаболических сдвигов в организме при онкологических заболеваниях может быть достигнута путем применения отдельных аминокислот или их комбинаций в качестве лекарственных средств. Предлагаемый аспект разработки новых рецептур лекарственных препаратов на основе аминокислот и родственных соединений ориентирован на коррекцию метаболических нарушений, возникающих при онкологической патологии, и во многом базируется на полученных нами результатах исследований особенностей формирования аминокислотного пула в биологических жидкостях и тканях при отдельных формах онкологической патологии. Показано, что содержание в инфузионных растворах высокоочищенных аминокислот должно в первую очередь определяться значениями их физиологической (эндогенной) концентрации, что отличает такие инфузионные растворы от традиционно используемых, в которых содержание аминокислот рассчитывается исходя из суточной потребности в них организма человека – без должного учета регулирующего действия вводимых соединений.
Changes in the amino acid pool of physiological fluids and their stock in tissues in malignant growth characterize cancer in a specific way. To a large extent, these changes are formed as a result of metabolic competition for common substrates for the plastic and energy needs of the body and the tumor. Targeted correction of metabolic shifts in oncopathology can be achieved by using particular amino acids or their combinations as medications. The proposed method of elaborating new drug formulations based on amino acids and related compounds is focused on the correction of metabolic disorders arising in oncopathology, and it is largely based on our studies’ findings concerning features of the amino acid "pool" formation in biological fluids and tissues in certain forms of oncopathology. The content of highly purified amino acids in infusion solutions should be primarily determined by their physiological (endogenous) concentrations, which distinguishes such infusion solutions from those traditionally used, in which the content of amino acids is calculated on the basis of daily requirements of the human body, without due consideration of administered compounds’ regulatory effect.
The Relationship Between Knowledge Level and Diet Behavior in Hypertension Patiens at Lepak Public Health Center
Authors: Taufandas Maruli , Apriani Susmita Sari  , Leni Syne Andriani  , Emdat Suprayitno  
Published: April 2023

Hypertension is an increase of systolic blood pressure at least 140 mmHg or diastolic pressure atleast 90 mmHg. Factors that influence hypertension are consumption of foods generally contain a lot of salt, high fat and high sugar. Bad diet behavior and knowledge level can influence this. To determine the relationship of level knowledge and diet behaviour of hypertension patients in Lepak Primary Health Centre.The design study using a quantitative analytical observational with cross sectional approach.The number of samples were 59 respondents and taken by using purposive sampling approach.The statistical test used in this study is the Spearman Rank test.There is a relationship between level knowledge with diet behavior of hypertension patients, with p value= 0,000 (p <0.05). The next test to determine the strength of the correlation between the level of knowledge and behavior with a value of 0.373, which means that the strength of the category relationship is quite strong and the direction of the relationship is positive.High knowledge and more positive attitudes have a good impact for hypertension patients, so that it can be recommended for patients to improve knowledge and attitudes to become the basic for following basi s to recommended diet.
PENGARUH BUDAYA ORGANISASI DAN EMPLOYE ENGGAMENT TERHADAP KINERJA KARYAWAN PADA PT. BUMI MINERAL SULAWESI
Authors: Yunus Yunus , Kasran Muhammad , Sampetan Suparni 
Published: April 2023

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh budaya organisasi dan employee enggament terhadap kinerja karyawan pada PT. Bumi Mineral Sulawesi. Sampel dalam penelitian ini terdiri dari 70 responden. hipotesis di uji dengan analisis regresi linear berganda menggunakan Aplikasi SMART PLS. Hasil penelitian pengaruh budaya organisasi terhadap kinerja karyawan berpengaruh positif signifikan terhadap kinerja karyawan, employee enggament berpengaruh positif terhadap kinerja karyawan
Kata Kunci: budaya organisasi, employee enggament, dan kinerja karyawan
Controlling the magnetism of oxide semiconductor nanoparticles of TiO2 prepared by a milling method
Authors: Yamanouchi Taiga , Nakazawa Takuto , Fukawa Akihiro , Takase Kouichi 
Published: April 2023

Abstract
In this study, we prepared pristine TiO2 nanoparticles with RT ferromagnetism using a pulverizing method. Annealing under gas circumstances (H2, O2, vacuum) confirmed the controlling possibility of the magnetism, including diamagnetism, paramagnetism, and ferromagnetism, of nanoparticles. Our findings showed that saturation magnetization is also controllable. This result is of great importance in the realization of Si-based spintronics devices because no prohibited transition metal elements were used in this study.
PANDANGAN TOKOH AGAMA TERHADAP PENGELOLAAN ZAKAT FITRAH UNTUK MELUNASI HUTANG PEMBANGUNAN MASJID
Authors: Ulum Bahrul , Mukhammad Nur Azis  
Published: April 2023

Pengelolaan zakat fitrah di Dusun Kalipakem Kecamatan Donomulyo sering dilakukan oleh takmir masjid dan mushala. Zakat fitrah bukan sekedar disalurkan terhadap fakir miskin, tetapi disalurkan pula untuk membiayai pembangunan masjid/mushala. Kenyataan ini tentunya melatar belakangi pandangan tokoh agama Dusun Kalipakem Kecamatan Donomulyo berhubungan dengan penyaluran zakat fitrah untuk pembangunan masjid.
Rumusan masalah pada penelitian ini meliputi : 1) Bagaimana pengelolaan zakat di Dusun Kalipakem Kecamatan Donomulyo? 2) Bagaimana pandangan tokoh agama Dusun Kalipakem Kecamatan Donomulyo terhadap pengelolaan zakat fitrah untuk hutang pembangunan masjid? Kajian dalam penelitian ini bertujuan untuk : 1) Mendeskripsikan pengelolaan zakat di Dusun Kalipakem Kecamatan Donomulyo. 2) Menganalisis pandangan tokoh agama Dusun Kalipakem Kecamatan Donomulyo terhadap pengelolaan zakat fitrah untuk hutang pembangunan masjid.
Modeling and Detection of Dynamic Position Sensor Offset Error in PMSM Drives
Authors: Kuruppu Sandun , Abeyratne Sunil , Hettiarachchi Sandun 
Published: April 2023

<p> Rotor position information obtained through a position sensor is crucial for proper field-oriented control (FOC) of permanent magnet synchronous machine based high dynamic energy conversion applications. In applications such as transportation and industrial, PMSM energy conversion systems are subjected to harsh environmental conditions such as vibration, shock, and thermal shock causing mechanical interfaces holding positions sensors to fail, introducing error to the position measurement. A dynamic position sensor offset error (DPSOE), being such a failure mode has the potential to degrade system torque output or more adversely, reverse machine torque output that may cause catastrophic outcomes. This paper evaluates different DPSOE scenarios, presents an approach to model the failure mode for analysis and proposes two novel and robust DPSOE detection methods for PMSM drive systems. The proposed detection methods are analytically proven and supported by simulation and experimental results under multiple operating conditions proving robustness. </p>
Blockage and RIS Cooperative Joint Beamforming for mmWave MIMO Systems
Authors: Sarker Md Abdul Latif , Baek Minjin , Seog Han Dong 
Published: April 2023

<p>The revised version has been submitted to the IEEE Transactions on Vehicular Technology.</p>
<p><br></p>
<p> A reconfigurable intelligent surface (RIS) is a kind of metasurface that provides an adaptable way of controlling the propagation of radio signals in wireless systems, allowing for improved coverage and system efficiency. Instead of the traditional RIS-assisted single-to-multiple reflection channel, we present a time-variant location-based hybrid reflection channel(TL-HRC) model in this paper. The designed TL-HRC model can easily tune a cooperative situation between the mobile blockage and RIS in millimeter wave massive multiple-input and multiple-output systems and satisfactorily scale a high received power gain. Based on the designed TL-HRC model, we establish a joint active and passive beamforming problem for the weighted sum rate maximization and propose an alternative optimization with a RIS element selection (AO-RES) algorithm to tackle the challenging high dimensional coupled parameters. Through simulation experiments the effectiveness of the proposed TL-HRC-based AO-RES algorithm is validated in terms of the weighted sum rate with the case of perfect channel state information.</p>