bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managerial inclusiveness and corporate innovation in China
Authors: Deng Siyi , He Jie 
Published: July 2023

AbstractThis study explores how managerial inclusiveness affects corporate innovation. Using an annual dataset of A‐share Chinese listed companies from 2008 to 2021, we find that managerial inclusiveness is positively related to corporate innovation. Market competition and team heterogeneity positively moderate the relationship between managerial inclusiveness and innovation. In addition, managerial inclusiveness in state‐owned enterprises plays a more significant role in promoting corporate innovation than it does in non‐state‐owned enterprises. By investigating the mechanism of influence, we found that inclusive managers can promote corporate innovation by relaxing internal controls and increasing corporate risk‐taking.
Vintage capital and trade credit
Authors: Khoo Joye , Cheung Adrian (Wai Kong) 
Published: July 2023

AbstractThis paper examines whether and how capital age influences trade credit extended by suppliers. We find that firms with older capital are associated with a reduction in trade credit offered by suppliers, which is consistent with the view that vintage capital, with outdated technology, is detrimental to firms. Employee outside opportunity, labour mobility and organisational capital are important factors that moderate the association between capital age on trade credit. Our findings are not driven by specific industry sectors or periods and remain robust to alternative measures of trade credit and to endogeneity concerns. In addition, we show evidence that shareholders view vintage capital as value‐destructive. In sum, this study reveals that risk exposure associated with capital age matters for corporate trade credit decisions.
Colorectal polyp outcomes after participation in the seAFOod polyp prevention trial: Evidence of rebound elevated colorectal polyp risk after short‐term aspirin use
Authors: Downing Amy , Fenton Hayley , Nickerson Claire , Loadman Paul M. , Williams Elizabeth A. , Rees Colin J. , Brown Louise C. , Morris Eva J. A. , Hull Mark A. 
Published: July 2023

SummaryBackgroundThe seAFOod polyp prevention trial was a randomised, placebo‐controlled, 2 × 2 factorial trial of aspirin 300 mg and eicosapentaenoic acid (EPA) 2000 mg daily in individuals who had a screening colonoscopy in the English Bowel Cancer Screening Programme (BCSP). Aspirin treatment was associated with a 20% reduction in colorectal polyp number at BCSP surveillance colonoscopy 12 months later. It is unclear what happens to colorectal polyp risk after short‐term aspirin use.AimTo investigate colorectal polyp risk according to the original trial treatment allocation, up to 6 years after trial participation.MethodsAll seAFOod trial participants were scheduled for further BCSP surveillance and provided informed consent for the collection of colonoscopy outcomes. We linked BCSP colonoscopy data to trial outcomes data.ResultsIn total, 507 individuals underwent one or more colonoscopies after trial participation. Individuals grouped by treatment allocation were well matched for clinical characteristics, follow‐up duration and number of surveillance colonoscopies. The polyp detection rate (PDR; the number of individuals who had ≥1 colorectal polyp detected) after randomization to placebo aspirin was 71.1%. The PDR was 80.1% for individuals who had received aspirin (odds ratio [OR] 1.13 [95% confidence interval 1.02, 1.24]; p = 0.02). There was no difference in colorectal polyp outcomes between individuals who had been allocated to EPA compared with its placebo (OR for PDR 1.00 [0.91, 1.10]; p = 0.92).ConclusionIndividuals who received aspirin in the seAFOod trial demonstrated increased colorectal polyp risk during post‐trial surveillance. Rebound elevated neoplastic risk after short‐term aspirin use has important implications for aspirin cessation driven by age‐related bleeding risk. ISRCTN05926847.
Exploring the role of ex vivo metabolism on blood and plasma measurements of oxytocin among women in the third stage of labour: A post hoc study
Authors: Oliver Victoria L. , Siederer Sarah , Cahn Anthony , Gajewska‐Knapik Katarzyna , Gibson Rachel A. , Goodall Cleo , Kirkpatrick Carl , Murray Jack , Nguyen Tri‐Hung , Schneider Ian , Lambert Pete , McIntosh Michelle P. , Parry Simon 
Published: July 2023

AimsTo examine the role of ex vivo oxytocin metabolism in post‐dose peptide measurements.MethodsThe stability of oxytocin (Study 1) and oxytocinase activity (Study 2) in late‐stage pregnancy blood was quantified using liquid‐chromatography tandem mass‐spectrometry (LC–MS/MS) and a fluorogenic assay, respectively. Analyses were conducted using blood from pregnant women (>36 weeks gestation) evaluated in lithium heparin (LH), ethylenediaminetetraacetic acid (EDTA) and BD P100 blood collection tubes with or without protease inhibitors. In addition, plasma oxytocin concentrations following administration of oxytocin 240 IU inhaled, 5 IU intravenous or 10 IU intramuscular in women in third stage of labour (TSL) were analysed using enzyme‐linked immunosorbent assay (ELISA) and LC–MS/MS to understand how quantified peptide concentrations differ between these analytical methods (Study 3).ResultsStudy 1: Oxytocin was stable in blood collected into EDTA tubes with or without protease inhibitors but not in LH tubes. Study 2: Blood collected into all EDTA‐containing collection tubes led to near‐complete inhibition of oxytocinase (≤100 min). In plasma, a 35% reduction in oxytocinase activity was observed in LH tubes with EDTA added. In plasma from late‐stage pregnancy compared to nonpregnant participants, the oxytocinase activity was approximately 11‐fold higher. Study 3: Plasma oxytocin concentrations from nonpregnant or women in TSL following exogenous oxytocin administration were ≤33 times higher when analysed using ELISA vs. LC–MS/MS methods.ConclusionsCollection of blood from late‐stage pregnant women into tubes containing EDTA inhibits oxytocinase effectively stabilizing oxytocin, suggesting low concentrations of oxytocin after dose administration reflect rapid in vivo metabolism.
Individual‐level brain morphological similarity networks: Current methodologies and applications
Authors: Cai Mengjing , Ma Juanwei , Wang Zirui , Zhao Yao , Zhang Yijing , Wang He , Xue Hui , Chen Yayuan , Zhang Yujie , Wang Chunyang , Zhao Qiyu , Xue Kaizhong , Liu Feng 
Published: July 2023

AbstractAimsThe human brain is an extremely complex system in which neurons, clusters of neurons, or regions are connected to form a complex network. With the development of neuroimaging techniques, magnetic resonance imaging (MRI)‐based brain networks play a key role in our understanding of the intricate architecture of human brain. Among them, the structural MRI‐based brain morphological network approach has attracted increasing attention due to the advantages in data acquisition, image quality, and in revealing the structural organizing principles intrinsic to the brain. This review is to summarize the methodology and related applications of individual‐level morphological networks.BackgroundThere have been a growing number of studies related to brain morphological similarity networks. Conventional morphological networks are intersubject covariance networks constructed using a certain morphological indicator of a group of subjects; individual‐level morphological networks, on the other hand, measure the morphological similarity between brain regions for individual brains and can reflect the morphological information of single subjects. In recent years, individual morphological networks have demonstrated significant worth in exploring the topological changes of the human brain under both normal and disease conditions. Such studies provided novel perspectives for understanding human brain development and exploring the pathological mechanisms of neuropsychiatric disorders.ConclusionThis paper mainly focuses on the studies of brain morphological networks at the individual level, introduces several ways for network construction, reviews representative work in this field, and finally points out current problems and future directions.
Moving beyond eat less, move more using willpower: Reframing obesity as a chronic disease impact of the 2020 Canadian obesity guidelines reframed narrative on perceptions of self and the patient–provider relationship
Authors: English Sara , Vallis Michael 
Published: July 2023

SummaryObesity is becoming recognized as a complex, chronic medical condition. However, the dominant treatment narrative remains that goal weight can be achieved by eating less, moving more using willpower, placing responsibility for change on the person with obesity (PwO). This study evaluated the impact of revising this narrative, to viewing obesity as a treatable medical condition, on internalized weight bias and perceived patient–provider relationship. PwO were recruited into an online study in which two videos were presented; the first showing a traditional doctor endorsing the eat less, move more approach, and the second showing a doctor describing obesity as a treatable medical condition. After each video participants were asked to imagine that they were being treated by that doctor and completed the Weight Bias Internalization Scale (WBIS) and the Patient–Health Care Provider Communication Scale (PHCPCS). A total of 61 PwO (52% response rate) completed the protocol. Compared to the traditional narrative video, the revised narrative video resulted in significant reductions in WBIS scores and significant increases in the PHCPCS scores and was preferred by participants. Within the context of this small‐scale study evidence supports that the revised narrative promoting obesity as a complex, chronic but treatable medical condition that is not the result of personal failure has a positive impact on the perceived patient–provider relationship and is associated with reductions in internalized weight bias. This evidence supports the need to help PwO reframe obesity from a personal failure to a legitimate medical condition worthy of care.
Rubber's inclusion in zero‐deforestation legislation is necessary but not sufficient to reduce impacts on biodiversity
Authors: Warren‐Thomas Eleanor , Ahrends Antje , Wang Yunxia , Wang Maria M. H. , Jones Julia P. G. 
Published: July 2023

AbstractAgricultural commodity production is a major driver of tropical deforestation and biodiversity loss. Natural rubber from Hevea brasiliensis, a valuable commodity without viable substitutes, has recently been included in the European Union (EU) deforestation regulation that aims to halt imports of goods containing embedded deforestation. Sustained growth in demand for rubber is driven by increasing tire production, caused by rising transport flows and personal car ownership. We show that average natural rubber yields remain static, meaning 2.7–5.3 million ha of additional plantations could be needed by 2030 to meet demand. A systematic literature search identified 106 case studies concerning transitions to and from rubber, revealing that substantial rubber plantation area expansion since 2010 has occurred at the expense of natural forest. Eliminating deforestation from rubber supply chains requires support for millions of smallholder growers to maintain or increase production from existing plantations, without land or water degradation. Supply chain traceability efforts offer opportunities to deliver such support. While the inclusion of rubber in EU legislation is a positive step, it is critical to ensure that smallholders are not marginalized to avoid exacerbating poverty, and that other markets follow suit to avoid displacement of rubber‐driven deforestation to unregulated markets.
Transfusion requirements and complication rate in β‐thalassemia intermedia due to heterozygous β‐globin gene mutation and triplicated α‐globin genes
Authors: Bonello‐Palot Nathalie , Benoit Audrey , Agouti Imane , Hamouda Ilyes , Brousse Valentine ,   NaThalY Network, Badens Catherine 
Published: July 2023

AbstractIntroductionThe heterozygous condition for β‐thalassemia mutation associated with an extra functional α‐globin gene can produce a Thalassemia Intermedia (TI) phenotype. This genotype is the second in frequency in the French Thalassemia Registry NaThalY that prospectively collects laboratory and clinical data.Materials and MethodsThe present report analyses transfusion needs, iron overload (ferritin, hepatic and cardiac iron concentrations), and complication rates in 45 patients included in NaThalY and presenting a heterozygous β0 or β+‐thalassemia mutation associated with a triplication at HBA locus. This cohort was compared to a cohort of patients with TI due to mutations in the beta‐globin gene only and included in the French registry.ResultsPatients with an extra functional α‐globin gene showed a less severe anemia, lower transfusion needs and lower complication rates than those with TI related to the β‐globin gene only. Nevertheless, some of them displayed complications such as cholelithiasis or extramedullary hematopoiesis. In addition, one third of the cohort needed transfusions and another third was under iron chelation.ConclusionThe genotype associating a heterozygous β0 or β+‐thalassemia mutation with a triplication at HBA locus should be accurately diagnosed as it could lead to symptomatic anemia and to potential iron overload and iron‐related complications even in patients with no transfusion need.
Persistence of a proinflammatory status after treatment of the acute myocardial infarction
Authors: da Silva Leandro Santos , Germano Danielle Borges , Fonseca Francisco Antonio Helfenstein , Shio Marina Tiemi , da Silva Nali Luiz Henrique , Tuleta Izabela Dorota , Juliano Yára , de Oliveira Izar Maria Cristina , Ribeiro Ana Paula , Kato Juliana Tieko , do Amaral Jônatas Bussador , França Carolina Nunes 
Published: July 2023

AimTo evaluate the lipid‐lowering and antiplatelet combined strategies on the expression of the receptors CCR2, CCR5, and CX3CR1 and the percentage of CCR2, CCR5, and CX3CR1 cells in monocyte subtypes after acute myocardial infarction.MethodsProspective, randomized, open‐label study, with blinded analyses of endpoints (PROBE,ClinicalTrials.govIdentifier: NCT02428374, registration date: April 28, 2015). Participants were treated with rosuvastatin 20 mg or simvastatin 40 mg plus ezetimibe 10 mg, as well as ticagrelor 90 mg or clopidogrel 75 mg. The chemokine receptors CCR2, CCR5, and CX3CR1 were analyzed by real‐time polymerase chain reaction as well as the percentages of CCR2, CCR5, and CX3CR1 cells in the monocyte subtypes (classical, intermediate, and non‐classical), which were quantified by flow cytometry, at baseline, and after 1 and 6 months of treatment.ResultsAfter comparisons between the three visits, regardless of the treatment arm, there was an increase in CCR2 expression after treatment, as well as an increase in intermediate monocytes CCR2+ and a reduction in non‐classical monocytes CCR2+ at the end of treatment. There was also a lower expression of CCR5 after treatment and an increase in classical and non‐classical monocytes CCR5+. Concerning CX3CR1, there were no differences in the expression after treatment; however, there were reductions in the percentage of intermediate and non‐classical monocytes CX3CR1+ at the end of treatment.ConclusionsThe results suggest the persistence of the inflammatory phenotype, known as trained immunity, even with the highly‐effective lipid‐lowering and antiplatelet therapies.Geriatr Gerontol Int 2023; 23: 700–707.
Predictive model containing gene signature and shear wave elastography to predict patient outcomes after Kasai surgery in biliary atresia
Authors: Wang Guotao , Chen Huadong , Sun Panpan , Zhou Wenying , Jiang Hong , Zhong Zhihai , Chen Meixi , Xie Xiaoyan , Luo Zhenhua , Zhou Luyao 
Published: July 2023

AbstractAimsInfants with biliary atresia (BA) are treated with Kasai portoenterostomy (KPE) surgery, but many BA patients need subsequent salvage liver transplants. The aim of this study is to develop a comprehensive gene‐clinical model based on two‐dimensional shear wave elastography (2DSWE), liver gene expression, and other clinical parameters to predict response to KPE for BA patients.MethodsDifferentially expressed gene patterns between liver samples of BA (n = 102) and non‐BA control (n = 14) were identified using RNA sequencing analysis. Biliary atresia patients were then randomly assigned to training and validation cohorts. Gene classifier based on the differentially expressed genes was built in the training cohort. Nomogram models with and without gene classifier were further constructed and validated for predicting native liver survival of BA patients. The utility of the nomograms was compared by C‐index.ResultsUsing the least absolute shrinkage and selection operator model, we generated a nine‐gene prognostic classifier. The nomogram based on the nine‐gene classifier, age, preoperative 2DSWE, and albumin had the better C‐index compared to gene classifier alone in the training cohort (0.83 [0.76–0.90] vs. 0.69 [0.61–0.77], p = 0.003) and the validation cohort (0.74 [0.67–0.82] vs. 0.62 [0.55–0.70], p = 0.001). Using risk scores developed from the nomogram, the 12‐month survival rates of BA patients with native liver were 35.7% (95% confidence interval [CI], 22.7–56.3) in the high‐risk group and 80.8% (95% CI, 63.4–100.0) in the low‐risk group in the validation cohort.ConclusionsThe comprehensive genetic‐clinical nomogram based on preoperative 2DSWE, liver gene expression, and other clinical parameters can accurately predict response to KPE.
Aroma of peach fruit: a review on aroma volatile compounds and underlying regulatory mechanisms
Authors: Li Xiaoying , Gao Peng , Zhang Chenguang , Xiao Xiao , Chen Caixia , Song Fuhang 
Published: July 2023

SummaryPeach is a highly significant economic fruit renowned for its juicy flesh, delectable taste, and pleasant aroma, which has made it a consumer favourite. Improving fruit quality often involves enhancing its aroma, as it is widely acknowledged that the aroma of a fruit plays a crucial role. However, the formation of aroma volatiles is dynamic and varies with fruit development and ripening and is closely linked to genetic background, cultivation management, and post‐harvest treatment. In recent years, many studies have been conducted to investigate the biosynthetic pathways involved in generating fruit aroma. However, the understanding of the underlying regulatory mechanisms remains limited. With the advancement in molecular biology and multi‐omics techniques, researchers have gained fresh insights into the molecular functions of peach genes, which holds significant implications for enhancing fruit flavour and advancing modern breeding programs. This review aims to summarise the most recent findings pertaining to aroma volatile compounds, shed light on the underlying regulatory mechanisms, and dissect the primary fields of peach fruit aroma research. Its purpose is to provide critical information that will facilitate a profound investigation into the specific components responsible for peach aroma and the mechanisms by which they are regulated.
Eras of designer Tregs: Harnessing synthetic biology for immune suppression
Authors: Tuomela Karoliina , Salim Kevin , Levings Megan K. 
Published: July 2023

SummarySince their discovery, CD4+CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly established as a critical cell type for regulating immune homeostasis through a plethora of mechanisms. Due to their immunoregulatory power, delivery of polyclonal Tregs has been explored as a therapy to dampen inflammation in the settings of transplantation and autoimmunity. Evidence shows that Treg therapy is safe and well‐tolerated, but efficacy remains undefined and could be limited by poor persistence in vivo and lack of antigen specificity. With the advent of new genetic engineering tools, it is now possible to create bespoke “designer” Tregs that not only overcome possible limitations of polyclonal Tregs but also introduce new features. Here, we review the development of designer Tregs through the perspective of three ‘eras’: (1) the era of FOXP3 engineering, in which breakthroughs in the biological understanding of this transcription factor enabled the conversion of conventional T cells to Tregs; (2) the antigen‐specificity era, in which transgenic T‐cell receptors and chimeric antigen receptors were introduced to create more potent and directed Treg therapies; and (3) the current era, which is harnessing advanced genome‐editing techniques to introduce and refine existing and new engineering approaches. The year 2022 marked the entry of “designer” Tregs into the clinic, with exciting potential for application and efficacy in a wide variety of immune‐mediated diseases.
An alternative assessment approach to global logistics performance evaluation: Common weight H‐DEA approach
Authors: Yu Ming‐Miin , Rakshit Ipsita 
Published: July 2023

AbstractThe goal of this study is to investigate the objective importance of the categories and sub‐indicators constituting the Logistics Performance Index (LPI) and try to answer which of these LPI's indicators has the most significant importance and to provide a guidance tool for policymakers to devise policies in logistics and transportation. Hence, this study puts forth an integrated multi‐attribute decision‐making technique coalesced with the hierarchical data envelopment analysis and assurance region. For different income groups and regions, this model is employed to reassess the scores and rankings of LPI that are obtained from the World Bank. Displaying a higher objectivity than World Bank's method, the results demonstrate no substantial difference in the rankings obtained under both the proposed and World Bank's methods. Moreover, service delivery performance was found to be more vital to LPI than policy regulations. In terms of global weighting, of the six sub‐indicators, timeliness is the most important. These findings provide a guidance tool for policymakers to devise policies in logistics as well as in transportation. With the common weights that have been utilized, the results may direct toward different priorities in terms of policies, compared to World Bank.
Multicultural personality and intergroup forgiveness between United States political parties
Authors: Perez Michael J. , Kenworthy Jared B. , Salter Phia S. 
Published: July 2023

AbstractThe purpose of this research was to investigate whether multicultural personality orientation as measured by the Multicultural Personality Questionnaire short form (MPQ) predicted intergroup forgiveness, decisions to forgive, revenge intentions, and avoidance intentions in the context of U.S. political conflict. We conducted three replicated studies across three different political, contextual samples. Study 1 was collected from a majority liberal, majority People of Color sample (N = 301), Study 2 was a majority liberal, majority White sample (N = 125), and Study 3 was a majority conservative, majority White sample (N = 160). Participants in these studies completed items from the MPQ short form and read a hypothetical political violence event committed against their political ingroup by a political outgroup. Overall, we found that the cultural empathy subscale of the MPQ short form was a consistent positive predictor of forgiveness even in the presence of other relevant predictors such as strength of ingroup identification and political ideology. We also performed a mini meta‐analysis across our three collected studies which further supported cultural empathy as a consistent positive predictor of intergroup forgiveness.