bluuebunny/crossref_metadata_2025_split huggingface dataset:
O VELHO E O NOVO: AS TRANSFORMAÇÕES DA PAISAGEM DO BAIRRO SÃO CONRADO EM ARACAJU-SE / THE OLD AND THE NEW: THE TRANSFORMATIONS OF THE LANDSCAPE OF THE NEIGHBORHOOD ARE CONRADO IN ARACAJU-SE
Authors: Teles Dayane Suelen Pereira Nascimento , Pinheiro Fabiana dos Santos , Pereira Ronald dos Santos , Sampaio Andrecksa Viana Oliveira 
Published: June 2023

Esse artigo analisa a dinâmica das transformações do bairro São Conrado em Aracaju- SE, desde a sua institucionalização até os dias atuais. Ressaltando que, com a criação da Fábrica Santa Cruz e a expansão do Distrito Industrial da capital sergipana surgiram às primeiras concentrações populacionais. No entanto, ao longo dos anos, principalmente no momento de sua institucionalização, diversos problemas socioeconômicos (saneamento, infraestrutura viária e social, etc.) refletiram na vida dos moradores, estando esses localizados num espaço de transição entre bairros centrais e periféricos da capital. Recentemente, a paisagem do bairro ganha novas formas, em especial pelo avanço do capital imobiliário. Em meio a essas transformações, a população local enxerga a paisagem do bairro, de maneira diferenciada. Para tanto, é válido analisar as diferentes visões das mudanças da paisagem, com o intuito de compreender as contradições inerentes à lógica de organização espacial contemporânea. Os resultados apresentados são a reconstituição histórica do bairro, as transformações da paisagem ao longo dos anos e as demandas e a percepção dos moradores sobre o referido bairro.ABSTRACTThis article analyzes the dynamics of the transformations of the São Conrado neighborhood in Aracaju - SE, from its institutionalization to the present day. Emphasizing that, with the creation of the Santa Cruz Factory and the expansion of the Industrial District of the Sergipe capital, emerged the first population concentrations. However, over the years, mainly at the moment of its institutionalization, several socioeconomic problems (sanitation, road and social infrastructure, etc.) reflected in the life of the residents, being located in a space of transition between central and peripheral districts of the capital. Recently, the landscape of the neighborhood has gained new forms, especially by the advance of real estate capital. In the midst of these transformations, the local population sees the landscape of the neighborhood, in a different way. In order to do so, it is valid to analyze the different visions of landscape changes, in order to understand the contradictions inherent in the logic of contemporary spatial organization. The results presented are the historical reconstruction of the neighborhood, the transformations of the landscape over the years and the demands and the perception of the residents about the neighborhood.Keywords: Landscape; Landscape transformations; Contradictions of spatial organization.
Intelectuais e o Debate Sobre Violência Revolucionária nos Anos 1980: O Caso das Revistas Punto de Vista e La Ciudad Futura
Authors: Leite Isabel Cristina 
Published: June 2023

As revistas são fontes privilegiadas para análise de temas contemporâneos à sua existência. Neste artigo analisaremos o debate sobre a violência revolucionária por intelectuais de esquerda que tiveram alguma relação com organizações revolucionárias nos anos 1960-1970. Buscaremos este debate nas revistas Punto de Vista e La Ciudad Futura, revistas de linha editorial de esquerda, cujos editores, em algum momento de suas vidas, militaram e trabalharam juntos em outras experiências editoriais semelhantes. Daremos ênfase nas discussões dos anos 1980, período que, em alguma medida, as análises sofreram influência da teoria dos demônios, tirando da discussão a responsabilidade da sociedade na crescente onda de violência ocorrida naqueles anos. Estas primeiras análises críticas à atuação das esquerdas evitam tocar em pontos mais incômodos, como a dimensão ética e moral da cultura guerrilheira, desmitificando seus heróis e criticando os chamados “justiçamentos”.
Ventral Pallidal GABAergic Neuron Calcium Activity Encodes Cue-Driven Reward Seeking and Persists in the Absence of Reward Delivery
Authors: Scott Alexandra , Palmer Dakota , Newell Bailey , Lin Iris , Cayton Christelle A. , Paulson Anika , Remde Paige , Richard Jocelyn M. 
Published: June 2023

Reward-seeking behavior is often initiated by environmental cues that signal reward availability. This is a necessary behavioral response; however, cue reactivity and reward-seeking behavior can become maladaptive. To better understand how cue-elicited reward seeking becomes maladaptive, it is important to understand the neural circuits involved in assigning appetitive value to rewarding cues and actions. Ventral pallidum (VP) neurons are known to contribute to cue-elicited reward-seeking behavior and have heterogeneous responses in a discriminative stimulus (DS) task. The VP neuronal subtypes and output pathways that encode distinct aspects of the DS task remain unknown. Here, we used an intersectional viral approach with fiber photometry to record bulk calcium activity in VP GABAergic (VP GABA) neurons in male and female rats as they learned and performed the DS task. We found that VP GABA neurons are excited by reward-predictive cues but not neutral cues and that this response develops over time. We also found that this cue-evoked response predicts reward-seeking behavior and that inhibiting this VP GABA activity during cue presentation decreases reward-seeking behavior. Additionally, we found increased VP GABA calcium activity at the time of expected reward delivery, which occurred even on trials when reward was omitted. Together, these findings suggest that VP GABA neurons encode reward expectation, and calcium activity in these neurons encodes the vigor of cue-elicited reward seeking.SIGNIFICANCE STATEMENTVP circuitry is a major driver of cue-evoked behaviors. Previous work has found that VP neurons have heterogenous responses and contributions to reward-seeking behavior. This functional heterogeneity is because of differences of neurochemical subtypes and projections of VP neurons. Understanding the heterogenous responses among and within VP neuronal cell types is a necessary step in further understanding how cue-evoked behavior becomes maladaptive. Our work explores the canonical GABAergic VP neuron and how the calcium activity of these cells encodes components of cue-evoked reward seeking, including the vigor and persistence of reward seeking.
Effects of NALCN-Encoded Na+Leak Currents on the Repetitive Firing Properties of SCN Neurons Depend on K+-Driven Rhythmic Changes in Input Resistance
Authors: Yang Nien-Du , Mellor Rebecca L. , Hermanstyne Tracey O. , Nerbonne Jeanne M. 
Published: June 2023

Neurons in the suprachiasmatic nucleus (SCN) generate circadian changes in the rates of spontaneous action potential firing that regulate and synchronize daily rhythms in physiology and behavior. Considerable evidence suggests that daily rhythms in the repetitive firing rates (higher during the day than at night) of SCN neurons are mediated by changes in subthreshold potassium (K+) conductance(s). An alternative “bicycle” model for circadian regulation of membrane excitability in clock neurons, however, suggests that an increase in NALCN-encoded sodium (Na+) leak conductance underlies daytime increases in firing rates. The experiments reported here explored the role of Na+leak currents in regulating daytime and nighttime repetitive firing rates in identified adult male and female mouse SCN neurons: vasoactive intestinal peptide-expressing (VIP+), neuromedin S-expressing (NMS+) and gastrin-releasing peptide-expressing (GRP+) cells. Whole-cell recordings from VIP+, NMS+, and GRP+neurons in acute SCN slices revealed that Na+leak current amplitudes/densities are similar during the day and at night, but have a larger impact on membrane potentials in daytime neurons. Additional experiments, using anin vivoconditional knockout approach, demonstrated that NALCN-encoded Na+currents selectively regulate daytime repetitive firing rates of adult SCN neurons. Dynamic clamp-mediated manipulation revealed that the effects of NALCN-encoded Na+currents on the repetitive firing rates of SCN neurons depend on K+current-driven changes in input resistances. Together, these findings demonstrate that NALCN-encoded Na+leak channels contribute to regulating daily rhythms in the excitability of SCN neurons by a mechanism that depends on K+current-mediated rhythmic changes in intrinsic membrane properties.SIGNIFICANCE STATEMENTElucidating the ionic mechanisms responsible for generating daily rhythms in the rates of spontaneous action potential firing of neurons in the suprachiasmatic nucleus (SCN), the master circadian pacemaker in mammals, is an important step toward understanding how the molecular clock controls circadian rhythms in physiology and behavior. While numerous studies have focused on identifying subthreshold K+channel(s) that mediate day-night changes in the firing rates of SCN neurons, a role for Na+leak currents has also been suggested. The results of the experiments presented here demonstrate that NALCN-encoded Na+leak currents differentially modulate daily rhythms in the daytime/nighttime repetitive firing rates of SCN neurons as a consequence of rhythmic changes in subthreshold K+currents.
Assessment of CLOs, PLOs, ILOs, SLOs: An academic programme for educational theatre as a model
Authors: Zaghloul H. S. 
Published: June 2023

Introduction. Educational theatre combines integrated opportunities and forms of education using theatrical arts. It develops in students the ability to use their proactive experiences into absorbing and challenge social reality. The educational value of theatre and performing arts is widely recognised, leading to the integration of theater programmes into the curriculum of universities globally. These programmes are overseen by specialised departments, and universities have established resources for instruction and training. Aim. The present research aims to evaluate the educational outcomes of the Academic Programme for Educational Theatre at the Faculty of Specific Education at Mansoura University in Egypt to ensure that the graduates are ready for the changing conditions of the economy and the needs of the labour market. Concerning the same, the adoption of educational theatre as a model had not been evaluated in the country. Methodology and research methods. The current study finds the role of SLOs, CLOs, PLOs, and ILOs as measures to examine the impact of the educational theatre model. Using a mixed method with the survey of 50 students and interviews of 20 faculty members of the Academic Programme for Educational Theatre, the identification of educational theatre’s impact on the learning outcomes of students is determined. Results. The results show that academic educational programmes depend on the performing arts and the participation of the learner in vocal performance, acting, and movement, activate the learning process and make the educational environment more effectively and greatly improve the learning and practice process. The results also emphasised the significance of educational institutions, particularly universities, in adopting academic programmes that incorporate practical experience, training, hands-on activities, and utilising appropriate evaluation methods. Scientific novelty. These academic educational models help engage students to create a positive emotional state, drive curiosity, strive to excel, build national character, focus on social issues, and believe in their capabilities. Practical significance. Accreditation of academic programmes based on practice and training develops students psychologically and mentally and raises the level of academic achievement and professional and personal development. Therefore, the study recommended the adoption of educational theatre courses in Egypt to ensure that the students are prepared to adapt to the changes in the labour market.
Hipertensión arterial renovascular en niños. Informe de tres casos
Authors: Gahona Villegas Junior R , Reyes Jurado Pamela , Ríos Méndez Raúl E 
Published: June 2023

ANTECEDENTES: La hipertensión (HTA) renovascular es una patología poco frecuente en la edad pediátrica, existe compromiso del flujo sanguíneo renal por obstrucción de su arteria. La confirmación del diagnóstico se realiza mediante angiografía digital de substracción. La HTA debe ser controlada con terapia antihipertensiva. El tratamiento resolutivo es mediante angioplastia percutánea con balón o stent.
CASOS CLÍNICOS: Se presentan tres casos de niños de 1, 5 y 10 años con HTA a quienes se les realizó estudios de laboratorio e imagen no invasivos con resultados no concluyentes. Dada la alta sospecha de estenosis renal, se les realizó angiografía renal por cateterismo evidenciando estenosis de la arteria renal principal o de sus ramas, en el mismo acto se hizo angioplastia con balón en los 3 casos. Se logró disminuir y mantener la presión arterial inferior al p<95 sin medicación en dos de los casos. A los 3 años de seguimiento, solo uno de ellos mantiene medicación antihipertensiva y requiere nueva dilatación con balón y colocación de stent.

CONCLUSIONES: En esta serie los métodos de diagnóstico por imagen no invasivos no fueron concluyentes, informando solamente acerca de la asimetría renal. Niveles elevados de renina, aldosterona y alcalosis mixta generan alta sospecha para el diagnóstico. El tratamiento con IECA y ARA ll no tuvo repercusión en la función renal y podrían ser considerados como primera línea de tratamiento bajo monitoreo constante. La angiografía por cateterismo fue diagnóstica y terapéutica en el mismo acto.

PALABRAS CLAVE: hipertensión arterial, niños, estenosis arteria renal, angiografía renal, hiperreninemia
Insights into Candida Albicans: A New Perspective on Pathogenic Factors and Regulatory Mechanisms
Authors: Kamali Mohadeseh , Sarvtin Mehdi Taheri 
Published: June 2023

Candida albicans (C. albicans) is a polymorphic fungus that exists as a natural flora in the skin and mucosal surfaces of the body. However, under certain conditions, such as immunodeficiency, mucosal damage, antibiotic use, and cancer, this fungus can cause superficial and systemic infections. C. albicans is the most common opportunistic pathogenic fungus in humans and causes 60% of mucosal infections and 40% of candidemia cases. Several pathogenic factors have been identified that contribute to the pathogenic potential of this fungus. Among these factors, we can mention: hypha production, attachment, and biofilm formation, secretion of hydrolase enzymes, acquisition of micronutrients, adaptation to oxygen and nitrogen deficiency conditions, and growth at temperatures above 37 °C. This review article will investigate the pathogenic factors of C. albicans and their regulatory factors. For this purpose, articles published in national and international scientific databases, including PubMed/MEDLINE, Google Scholar, Elsevier databases, IranMedex, Scopus, SID, and Science Direct, were used. Keywords such as: “Candida,” “Fungi,” “Pathogenesis,” and “Virulence” were used to find the articles.
Effects of the Phytocompound Combination against Dysbiosis Induced by AGE-Rich High-fat Diet in Mice
Authors: Ghanbari Fahimeh , Abedpoor Navid , Peymani Maryam , Asadi-Yousefabad Seyedeh-leili , Lotfi Marzieh , Sheikhha Mohammad Hasan , Mazaheri-Naeini Mahta 
Published: June 2023

Background and Aims: The composition of the Microbiota can be influenced by various lifestyle and environmental factors, including diet. We designed a study to investigate the improving effects of plant extract, the combination of turmeric, ginger, boswellia, and cat’s claw on the abundance of key members of the gut microbiota, Bacteroidetes, Akkermansia muciniphila (A. muciniphila), Faecalibacterium prausnitzii (F. prausnitzii), Firmicutes and Bifidobacterium in mice treated with advanced glycation end products (AGE) rich high-fat diet (HFD).
Materials and Methods: Eighteen 2-month age male C57BL/6 mice were adopted to a regular diet for 1 week and then fed with an HFD or regular diet. After 8 weeks of diet, animals received plant extract concurrently with HFD for 8 weeks. Stools were taken, DNA of stool samples was extracted, and qPCR of 16s rDNA universal primers was performed. Then the effect of plant extract on dysbiosis induced by AGE-rich HFD was accessed.
Results: Our results revealed the frequencies of Bacteroidetes (p=0.001), A. muciniphila (p= 0.0005), F. prausnitzii (p<0.0001), and Bifidobacterium (p= 0.0008) were reduced, whereas the frequency of Firmicute was increased in the AGE-rich HFD group. A significant increase in the F/B ratio was observed in the HFD group than in the regular diet group (p= 0.0003). plant extract reduced the F/B ratio and improved gut microbiota homeostasis.
Conclusion: Plant extract restored gut microbiota patterns in HFD-treated mice. It seems more studies are required to prove the application of plant extracts for modulating the gut microbiota as a promising new biomarker with potential for therapeutic applications.
Investigating the impact of demographic factors and working with computers on the hand grip and pinch strength of office workers
Authors: MH Hosseini , Sharifzadeh GH R , Akbari A 
Published: June 2023

Introduction: In office tasks, pinch gripping of tools such as pen, paper, mouse, and keys are required during most working hours. This study aimed to determine the effect of demographic factors and working with a computer on office workers' hand grip and pinch strength.
Materials and Methods: In this cross-sectional analytical study, after recording the demographic characteristics, the hand grip and pinch strength of 174 employees of 20 offices of Birjand city with at least 3 hours of daily computer work was measured using a Jamar hand dynamometer and Saehan pinch gauge. The data were analyzed by SPSS statistical software version 16. In addition to descriptive statistics, ANOVA, independent t-test, and Pearson correlation coefficient were used.
Results: The mean and standard deviation related to the age of the subjects were 37.5 ± 7.15 and 13 ± 7.35 years. The relationship between the hand grip and pinch strength with the variables of sex, height, weight, and Handedness (except the tip of the males) was significant (P<0.05), but with the variables of BMI, work experience, and age (except palmar of the dominant hand) was not significant. Computer work duration significantly affected the dominant hand's grip strength and both hands' palmar and tip pinch (P<0.05).
Conclusion: The results of this study show the effect of computer work duration on reducing office workers' hand grip and pinch strength. Therefore, it is recommended to apply ergonomic principles to maintain hand grip and pinch strength of computer users.
Investigating the relationship between demographic characteristics, job stress and work ability in nurses: A cross-sectional descriptive study
Authors: Imenpanah M , Sadra Abargouei N , Sadri Esfahani A 
Published: June 2023

Introduction: Nurses play a critical role in the health of society. Previous studies have reported a high level of occupational stress in the nursing community. Therefore, the present study investigates the relationship between demographic characteristics and job stress on nurses' workability.
Materials and Methods: 408 nurses participated in this cross-sectional descriptive study. Data were collected using a demographic information questionnaire, nurses' job stress scale (NSS), and work ability index (WAI). SPSS version 24 statistical software and independent t-tests, one-way analysis of variance (ANOVA), and Pearson correlation were used for data analysis. The significance level in the present study was considered less than 0.05.
Results: The mean and standard deviation of the age of the nurses was 33.6 ± 5.1 years. 78.2% of the participants (319 nurses) were women, and the rest were men. 68.7% of female nurses (280 people) were married. Nurses had high job stress and poor workability. A significant negative relationship was observed between job stress and nurses' workability (P<0.001). Age and work experience had a negative significant relationship with occupational stress and a positive significant relationship with workability. Also, nurses with higher education had lower job stress and higher workability.
Conclusion: Considering the negative impact of occupational stress on the nurses' workability, it is suggested that the relevant managers identify and eliminate the factors that cause occupational stress to maintain health, improve the ability to work, and increase the productivity of nurses, to reduce the amount of occupational stress and improve the workability of nurses.
CHINESE POVERTY REDUCTION MODEL: A VIRILE TOOL FOR ACHIEVING POVERTY REDUCTION IN NIGERIA BY 2030
Authors: Adewale Omotayo Vincent , Adeyinka Adewole Joseph , Damilola Ogunlokun Ayodele 
Published: June 2023

Various strategies have been used by Nigerian government in a bid to stem the tide of rising poverty in the country but poverty appears not to have been abated judging from the available statistics. However, China has been able to reduce its poverty from 57% to less than 1% between 1999 and 2020. Therefore, this study appraised empirically the efficacy of Chinese poverty reduction model reducing poverty in Nigeria. Both the CBN Statistical Bulletin and World Bank Development Indicators were used as sources for the data. The data were analyzed using regression utilizing the Ordinary Least Square method. The results showed that agricultural productivity, a component of China's strategy to combat poverty, had a significant impact on reducing poverty in Nigeria. Additionally, it was discovered that government spending on social services, another Chinese strategy, had a beneficial effect on the eradication of poverty. It was discovered that a 1% increase in the amount spent on social and community services in Nigeria resulted in a 21% decline in the country's poverty rate. However, it was found that agricultural spending was inversely correlated with capital income, which went against the theoretical prediction. Therefore, it was determined that the Chinese model for decreasing poverty, which incorporates better agricultural techniques, higher social security, and community services, will be effective in significantly lowering poverty in Nigeria by 2030.Keywords: Poverty Reduction, Chinese Model, Agricultural Productivity, Social and Community Expenditure
Raw Denim as a Means of Communication: Self Expression and Identity
Authors: Rahmandani Fadhli , Sari Ratna Permata 
Published: June 2023

Fashion plays an important role in the self-identity formation processes. In this sense, jeans are getting increasingly popular as it has become a trend in fashion. This study examines how raw denim becomes a form of self-expression for its wearer. Applying a qualitative approach, this study has gathered the empirical data through in-depth interviews and observations to an Indonesian denim community called as INDIGO. This study shows that raw denim users have several ways to express themselves as raw denim users. Denim has characteristics that allow for personalization according to one’s body shape, especially the creases and fades that mark the daily habits of the wearer. Denim becomes a representation of the wearers and a way to express their self identity. In order to show that they are a denimhead, one must consider every related actions they take in using raw denim, including joining in a denim community. Keywords: denim, fashion, self expression, identity, Indonesian denim community.