bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protocol for the development of guidance for collaborator and partner engagement in health care evidence syntheses
Authors: Tugwell Peter , Welch Vivian , Magwood Olivia , Todhunter-Brown Alex , Akl Elie A. , Concannon Thomas W. , Khabsa Joanne , Morley Richard , Schunemann Holger , Lytvyn Lyubov , Agarwal Arnav , Antequera Alba , Avey Marc T. , Campbell Pauline , Chang Christine , Chang Stephanie , Dans Leonila , Dewidar Omar , Ghersi Davina , Graham Ian D. , Hazlewood Glen , Hilgart Jennifer , Horsley Tanya , John Denny , Jull Janet , Maxwell Lara J. , McCutcheon Chris , Munn Zachary , Nonino Francesco , Pardo Pardo Jordi , Parker Roses , Pottie Kevin , Rada Gabriel , Riddle Alison , Synnot Anneliese , Ghogomu Elizabeth Tanjong , Tomlinson Eve , Toupin-April Karine , Petkovic Jennifer 
Published: August 2023

Abstract
Background
Involving collaborators and partners in research may increase relevance and uptake, while reducing health and social inequities. Collaborators and partners include people and groups interested in health research: health care providers, patients and caregivers, payers of health research, payers of health services, publishers, policymakers, researchers, product makers, program managers, and the public. Evidence syntheses inform decisions about health care services, treatments, and practice, which ultimately affect health outcomes.
Our objectives are to:
A. Identify, map, and synthesize qualitative and quantitative findings related to engagement in evidence syntheses
B. Explore how engagement in evidence synthesis promotes health equity
C. Develop equity-oriented guidance on methods for conducting, evaluating, and reporting engagement in evidence syntheses

Methods
Our diverse, international team will develop guidance for engagement with collaborators and partners throughout multiple sequential steps using an integrated knowledge translation approach:
1. Reviews. We will co-produce 1 scoping review, 3 systematic reviews and 1 evidence map focusing on (a) methods, (b) barriers and facilitators, (c) conflict of interest considerations, (d) impacts, and (e) equity considerations of engagement in evidence synthesis.
2. Methods study, interviews, and survey. We will contextualise the findings of step 1 by assessing a sample of evidence syntheses reporting on engagement with collaborators and partners and through conducting interviews with collaborators and partners who have been involved in producing evidence syntheses. We will use these findings to develop draft guidance checklists and will assess agreement with each item through an international survey.
3. Consensus. The guidance checklists will be co-produced and finalised at a consensus meeting with collaborators and partners.
4. Dissemination. We will develop a dissemination plan with our collaborators and partners and work collaboratively to improve adoption of our guidance by key organizations.

Conclusion
Our international team will develop guidance for collaborator and partner engagement in health care evidence syntheses. Incorporating partnership values and expectations may result in better uptake, potentially reducing health inequities.
The cost of inadequate postharvest management of pulse grain: Farmer losses due to handling and storage practices in Uganda
Authors: Ariong Richard M. , Okello Daniel M. , Otim Michael Hilary , Paparu Pamela 
Published: August 2023

Abstract
Background
Investing in postharvest technologies is one way of reducing food losses with the aim of achieving food security, but it is often overlooked. In this study, we assessed the losses and costs associated with the harvest and postharvest practices used by smallholder bean farmers in Uganda. We also estimated the grain Moisture Content (MC) associated with traditional storage practices.

Results
Harvest and postharvest handling practices result in a loss of about 22% of the crop harvest. The cost associated with this loss is 17% of the output value. In addition, the common storage practices used by farmers are unable to maintain the required grain MC of ≤ 13%. As even a slight change in grain MC can significantly impact storage duration, we found that 74% of farmers fail to meet the required MC, resulting in a loss of anticipated price premiums over an average storage duration of 80 days. Our econometric estimates suggest that storing grain in bags placed above the floor surface could reduce MC by an additional 1.5%.

Conclusions
Our predictions indicate that farmers who use traditional practices should store bean grains for less than 60 days, or they should adopt better storage practices to increase shelf life and ensure food safety. If more farmers had placed their grain above the floor surface, 48% rather than 26% would have met the required MC at 90 days. It is worth noting that poor postharvest handling has significant economic implications and can lead to food safety concerns due to quality failures in the grain. To address these issues, there is a need to scale up interventions that increase farmer access to postharvest technologies.
Oligofructose improves small intestinal lipid-sensing mechanisms via alterations to the small intestinal microbiota
Authors: Weninger Savanna N. , Herman Chloe , Meyer Rachel K. , Beauchemin Eve T. , Kangath Archana , Lane Adelina I. , Martinez Taylor M. , Hasneen Tahia , Jaramillo Sierra A. , Lindsey Jason , Vedantam Gayatri , Cai Haijiang , Cope Emily K. , Caporaso J. Gregory , Duca Frank A. 
Published: August 2023

Abstract
Background
Upper small intestinal dietary lipids activate a gut-brain axis regulating energy homeostasis. The prebiotic, oligofructose (OFS) improves body weight and adiposity during metabolic dysregulation but the exact mechanisms remain unknown. This study examines whether alterations to the small intestinal microbiota following OFS treatment improve small intestinal lipid-sensing to regulate food intake in high fat (HF)-fed rats.

Results
In rats fed a HF diet for 4 weeks, OFS supplementation decreased food intake and meal size within 2 days, and reduced body weight and adiposity after 6 weeks. Acute (3 day) OFS treatment restored small intestinal lipid-induced satiation during HF-feeding, and was associated with increased small intestinal CD36 expression, portal GLP-1 levels and hindbrain neuronal activation following a small intestinal lipid infusion. Transplant of the small intestinal microbiota from acute OFS treated donors into HF-fed rats also restored lipid-sensing mechanisms to lower food intake. 16S rRNA gene sequencing revealed that both long and short-term OFS altered the small intestinal microbiota, increasing Bifidobacterium relative abundance. Small intestinal administration of Bifidobacterium pseudolongum to HF-fed rats improved small intestinal lipid-sensing to decrease food intake.

Conclusion
OFS supplementation rapidly modulates the small intestinal gut microbiota, which mediates improvements in small intestinal lipid sensing mechanisms that control food intake to improve energy homeostasis.
A synbiotic mixture of selected oligosaccharides and bifidobacteria assists murine gut microbiota restoration following antibiotic challenge
Authors: Hoedt Emily C. , Hueston Cara M. , Cash Nora , Bongers Roger S. , Keane Jonathan M. , van Limpt Kees , Ben Amor Kaouther , Knol Jan , MacSharry John , van Sinderen Douwe 
Published: August 2023

Abstract
Background
Typically, animal models studying gastrointestinal microbiotas compromised in early life have employed either germ-free animals or mice treated with a cocktail of antibiotics. Such studies intend to mimic scenarios of infants born by caesarean section and/or subjected to antibiotic treatment. However, the antibiotics used in these studies are rarely prescribed to infants. Therefore, an early life model was developed in which the murine gastrointestinal microbiota was severely disrupted by clindamycin treatment.

Results
In this mouse model, we investigated the extent supplementation with a synbiotic mixture of prebiotics, being scGOS/lcFOS with the human milk oligosaccharide 2’-Fucosyllactose (2’-FL), in combination with or without single strain or mix of “infant type” bifidobacteria, can rescue an antibiotic-compromised microbiota. Shotgun metagenomic sequencing showed that the microbiota was severely disrupted by the clindamycin challenge. No recovery was observed 3 weeks post-challenge in the scGOS/lcFOS/2’FL group, while the group that received the synbiotic treatment of scGOS/lcFOS/2’-FL with Bifidobacterium breve NRBB01 showed partial recovery. Strikingly in the scGOS/lcFOS/2’-FL group receiving the mixture of bifidobacteria resulted in a recovery of the microbiota disruption. Histological analyses showed that the clindamycin-treated animals at the end of the experiment still suffered from mild oedema and villi/colonic crypt irregularities which was ameliorated by the synbiotic intervention.

Conclusion
Our study demonstrates that supplementation of synbiotic mixture of scGOS/lcFOS/2’-FL in combination with a specific mix of infant-type bifidobacterial strains is able to partially revive an antibiotic-perturbed gastrointestinal microbiota.
The efficacy of non-invasive brain stimulation in the treatment of children and adolescents with Anorexia Nervosa: study protocol of a randomized, double blind, placebo-controlled trial
Authors: Ursumando Luciana , Ponzo Viviana , Monteleone Alessio Maria , Menghini Deny , Fucà Elisa , Lazzaro Giulia , Esposito Romina , Picazio Silvia , Koch Giacomo , Zanna Valeria , Vicari Stefano , Costanzo Floriana 
Published: August 2023

Abstract
Background
Current psychological and pharmacological treatments for Anorexia Nervosa (AN) provide only moderate effective support, and there is an urgent need for research to improve therapies, especially in developing age. Non-invasive brain stimulation has suggested to have the potential to reducing AN symptomatology, via targeting brain alterations, such as hyperactivity of right prefrontal cortex (PFC). We suppose that transcranial direct current stimulation (tDCS) to the PFC may be effective in children and adolescents with AN.

Methods
We will conduct a randomized, double blind, add-on, placebo-controlled trial to investigate the efficacy of tDCS treatment on clinical improvement. We will also investigate brain mechanisms and biomarkers changes acting in AN after tDCS treatment. Eighty children or adolescent with AN (age range 10–18 years) will undergo treatment-as-usual including psychiatric, nutritional and psychological support, plus tDCS treatment (active or sham) to PFC (F3 anode/F4 cathode), for six weeks, delivered three times a week. Psychological, neurophysiological and physiological measures will be collected at baseline and at the end of treatment. Participants will be followed-up one, three, six months and one year after the end of treatment. Psychological measures will include parent- and self-report questionnaires on AN symptomatology and other psychopathological symptoms. Neurophysiological measures will include transcranial magnetic stimulation (TMS) with electroencephalography and paired pulse TMS and repetitive TMS to investigate changes in PFC connectivity, reactivity and plasticity after treatment. Physiological measures will include changes in the functioning of the endogenous stress response system, body mass index (BMI) and nutritional state.

Discussion
We expect that tDCS treatment to improve clinical outcome by reducing the symptoms of AN assessed as changes in Eating Disorder Risk composite score of the Eating Disorder Inventory-3. We also expect that at baseline there will be differences between the right and left hemisphere in some electrophysiological measures and that such differences will be reduced after tDCS treatment. Finally, we expect a reduction of endogenous stress response and an improvement in BMI and nutritional status after tDCS treatment. This project would provide scientific foundation for new treatment perspectives in AN in developmental age, as well as insight into brain mechanisms acting in AN and its recovery.
Trial registration The study was registered at ClinicalTrials.gov (ID: NCT05674266) and ethical approval for the study was granted by the local research ethics committee (process number 763_OPBG_2014).
Survival outcome of patients undergoing salvage surgery for hypopharyngeal cancer after failure of primary curative treatment: a retrospective study
Authors: Chotipanich Adit 
Published: August 2023

Abstract
Objectives
Salvage surgery for hypopharyngeal cancer remains a major challenge, and only a few studies have been conducted. In this study, we review our 10 years of experience in treating patients with hypopharyngeal cancer. The main aim of this study is to analyze survival outcomes in patients who underwent salvage surgery compared with those who had complete remission or inoperable residual tumors.

Methods
Chart reviews were performed for all patients with hypopharyngeal squamous cell carcinoma who underwent curative treatment at a tertiary care hospital between 2009 and 2019. Data on survival, clinical course, and complications were analyzed.

Results
Salvage surgery was performed in 15 of the 34 patients with residual hypopharyngeal cancer. Of these, 10 patients with isolated residual neck disease underwent salvage neck dissection, and five patients with residual primary tumors underwent salvage total or partial laryngopharyngectomy.
The overall 3-year survival rate of patients who underwent salvage surgery was 33.3%. Patients who underwent salvage neck dissection alone had significantly better survival rates than those who received palliative treatment, with median survival times of 21 and 12 months, respectively. The median survival time of patients who underwent laryngopharyngectomy for residual primary tumors was 14 months, which was not significantly different from that of patients who received palliative treatments.

Conclusion
Salvage surgery was associated with improved survival in patients with hypopharyngeal cancer and isolated residual neck disease. Nevertheless, the survival benefit of salvage surgery in patients with residual primary disease remains unclear.
Liquidity and uncertainty: digital adaptation of a complex intervention for people with severe mental illness during the COVID-19 lockdown
Authors: Frost Julia , Hobson-Merrett Charley , Gask Linda , Clark Michael , Pinfold Vanessa , Plappert Humera , Reilly Siobhan , Gibson John , Richards Deborah , Denyer Rebecca , Byng Richard 
Published: August 2023

Abstract
Background
This paper explores the extent to which the implementation and evaluation of a collaborative care model of face-to-face service delivery for people with severe mental illness was viable during the first UK lockdown associated with COVID-19. The PARTNERS2 cluster randomised controlled trial and process evaluation were co-designed with service users and carers. The aim of this paper is to explore whether digital adaptation of the PARTNERS model for people with severe mental illness during the COVID-19 lockdown was equitable, in terms of fostering collaboration and trust in a vulnerable population.

Results
We collected qualitative data from multiple sources during lockdown and subsequently constructed case-studies of participating secondary care workers. We adopted Bauman’s notions of liquid modernity to inform our analysis, and identified that digital adaptation during lockdown was only successful where organisational policies, care partner skills and service users’ existing resources were optimal.

Conclusion
PARTNERS2 can be delivered digitally by a care partner to support people with severe mental illness to identify and work towards their goals when existing resources are optimal. However, at a time of increased need, we identified that people who are very unwell and living with limited access to resources and opportunities, remained disenfranchised at great cost.

Trial registration
ISRCTN 95702682, registered 26.10.2017
Population-level antagonism between FGF and BMP signaling steers mesoderm differentiation in embryonic stem cells
Authors: Gattiglio Marina , Protzek Michelle , Schröter Christian 
Published: August 2023

ABSTRACT
The mesodermal precursor populations for different internal organ systems are specified during gastrulation by the combined activity of extracellular signaling systems such as BMP, Wnt, Nodal and FGF. The BMP, Wnt and Nodal signaling requirements for the differentiation of specific mesoderm subtypes in mammals have been mapped in detail, but how FGF shapes mesodermal cell type diversity is not precisely known. It is also not clear how FGF signaling integrates with the activity of other signaling systems involved in mesoderm differentiation. Here, we address these questions by analyzing the effects of targeted signaling manipulations in differentiating stem cell populations at single-cell resolution. We identify opposing functions of BMP and FGF, and map FGF-dependent and -independent mesodermal lineages. Stimulation with exogenous FGF boosts the expression of endogenous Fgf genes while repressing Bmp ligand genes. This positive autoregulation of FGF signaling, coupled with the repression of BMP signaling, may contribute to the specification of reproducible and coherent cohorts of cells with the same identity via a community effect, both in the embryo and in synthetic embryo-like systems.
Development of an FeOOH Electrocatalyst for Water Oxidation from the Recycling of Disposable Body Warmers
Authors: Suginaga Taki , Tsunekawa Shun , Harada Kazuki , Tomomune Masahiro , Hasuike Rina , Fujimoto Keika , Wang Ke-Hsuan , Kawai Takeshi , Yoshida Masaaki 
Published: August 2023

Abstract
An electrocatalyst to promote the water oxidation reaction was obtained by the recycling of disposable body warmers with simple treatments. This material catalytically decomposed water molecules to generate oxygen gas. X-ray diffraction and Fe K-edge X-ray absorption spectroscopy analyses indicated that the catalyst was composed of the β-FeOOH structure. The recycling of waste materials was achieved by the application of disposable body warmers as β-FeOOH catalysts for water oxidation.
Business and publication model of surgical journals: a bibliometric analysis
Authors: Qazi Shurjeel Uddin , Usmani Shajie Ur Rehman , Naveed Naveen , Ansari Huzaifa , Qazi Sana , Altaf Zahabia 
Published: August 2023

Background: The research community is increasingly recognizing the significance of understanding journal business models and their influence on the dissemination and readership of scholarly literature. This has sparked discussions on publisher payment models, exemplified by the recent termination of the subscription contract between the University of California and Elsevier. Methods: Scopus was used as the primary database to extract the list of surgery journals and other variables related to journal metrics. SCImago Journal Ranking (SJR) was used to extract information about the journals such as name and type of publisher, language and location model of the journal and publication model. Data were analyzed using SPSS version 26. Results: More than half of surgical journals were published by university publishers (54.2%). Similarly more than half of the journals are of European origin (53%). About 1/3 of the surgical journals employ open access publication model. We obserevd a greater number of orthopedic subspeciality journals (19%). SJR was higher for university and commercial type of publishers. Conclusion: A small number of multinational commercial corporations dominate the publication of surgery journals, leading to significant centralization. Despite the majority of surgery journals being open access, their impact is similar to that of subscription-based journals.
Midiatização e disputa de sentidos na Amazônia: identidade cultural versus securitização
Authors: Machado da Silveira Ada Cristina , Hartmann Camila , Barros Bock Marjorie 
Published: August 2023

O artigo decorre de uma investigação da midiatização de processos comunicacionais no âmbito das fronteiras internacionais do Brasil em sua relação com países colindantes. A comunicação midiática é problematizada com a análise da atividade noticiosa realizada por via digital em contexto da Amazônia transfronteiriça. Investigamos as condições de exercício da comunicação de proximidade na mídia da tríplice fronteira Brasil, Colômbia e Peru (BRA-COL-PE). A metodologia consiste em uma revisão bibliográfica sobre o tema. A abordagem teórica considera prescrições de documentos oficiais dos Estados nacionais, além de literatura no tema da midiatização e da comunicação de proximidade. A análise do papel da mídia para a democratização e desenvolvimento da coesão local envolve considerar sua capacidade de superar a concepção de fronteira como espaço de fluxo em favor de um espaço de lugar. Nossa hipótese é a de que a compreensão da comunicação de proximidade exerce o mandato de integração tensionando as dimensões da identidade cultural transfronteiriça em construção com a dimensão securitária. Os resultados consideram que a ecologia midiática local concede suporte à atualização midiatizada da identidade cultural transfronteiriça, ao mesmo tempo em que reitera sentidos securitários, e o faz modalizando o impacto de políticas externas distintas e soberanistas para as fronteiras nacionais, no caso, de três Estados nacionais.
A Two-Step Synthetic Control Approach for Estimating Causal Effects of Marketing Events
Authors: Li Kathleen T. , Shankar Venkatesh 
Published: August 2023

Marketing researchers are often interested in estimating causal effects when a randomized experiment is infeasible. The synthetic control (SC) method has emerged as a powerful tool in these quasiexperimental settings. It is important to verify the SC parallel pretrends assumption, the testable part of the identifying assumption, because its violation may lead to biased estimates. However, no formal test exists, so researchers have to rely on visual inspection. Even with a formal test, researchers still need to know how to balance the bias-efficiency trade-off for the estimate. We fill this void and advance the two-step synthetic control (TSSC) approach that comprises a formal test for the SC pretrends assumption in the first step and recommends an appropriate method that balances the dual goal of reducing bias and increasing efficiency in the second step. Simulations show that the TSSC approach performs favorably in the bias-variance (bias-efficiency) trade-off. Applying the TSSC approach, we find that New York State’s repeal of the tampon tax caused a positive and significant (2.08%) increase in weekly tampon sales. Using theory, simulations, and empirics, we demonstrate the importance, validity, and usefulness of the TSSC approach. This paper was accepted by Matthew Shum, marketing. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4878 .