bluuebunny/crossref_metadata_2025_split huggingface dataset:
Streptomyces rugosispiralis sp. nov., a Novel Actinobacterium Isolated from Peat Swamp Forest Soil That Produces Ansamycin Derivatives and Nocardamines
Authors: Weeraphan Trinset , Supong Khomsan , Sripreechasak Paranee , Jutakanoke Rumpa , Kowinthanaphat Supalerk , Tanasupawat Somboon , Pittayakhajonwut Pattama , Phongsopitanun Wongsakorn 
Published: September 2023

Actinomycetes, especially the genus Streptomyces, are one of the most promising sources of bioactive natural products. In this study, a novel Streptomyces strain, RCU-064T, was isolated from a soil sample collected from a peat swamp forest in Thailand. Strain RCU-064T showed the highest 16S rRNA gene sequence similarity (99.06%) with Streptomyces malaysiensis NBRC 16446T. Based on a polyphasic approach, strain RCU-064T represents a novel species of the genus Streptomyces, for which the name Streptomyces rugosispiralis sp. nov. is proposed. The chemical isolation of the crude ethyl acetate extracts of the strain led to the isolation of six compounds: (1) geldanamycin, (2) 17-O-demethylgeldanamycin, (3) reblastatin, (4) 17-demethoxyreblastatin, (5) nocardamine, and (6) dehydroxynocardamine. These compounds were evaluated for their biological activities. All compounds showed no antimicrobial activity against tested microorganisms used in this study. Compounds (1)–(4) displayed cytotoxic activity against the NCI-H187 cell line, with IC50 values ranging from 0.045–4.250 µg/mL. Cytotoxicity against the MCF-7 cell line was found in compounds (1) and (3) with IC50 values of 3.51 and 1.27 µg/mL, respectively. Compounds (5) and (6) exhibited cytotoxicity only against Vero cells (IC50 of 16.57 µg/mL) and NCI-H187 cells (IC50 of 13.96 µg/mL), respectively. These results indicate that peat swamp forest soil remains a promising reservoir of novel actinomycetes capable of producing bioactive natural products.
Associations of Dietary Inflammatory Potential with Esophageal Precancerous Lesions and Esophageal Squamous-Cell Cancer: A Cross-Sectional Study
Authors: Dong Jingwen , Gao Min , Li Lin , Pan Xiaoyu , Chen Sheng-Yin , Li Jun , Smith-Warner Stephanie A. , Li Xiaoguang , Wang Hui , Zheng Jiali 
Published: September 2023

Chronic inflammation plays a central role in the progression from esophageal precancerous lesions (EPLs) to esophageal squamous-cell cancer (ESCC). However, few studies have investigated the relationship between the overall inflammatory potential of diets and EPLs and ESCC. We aimed to study the association between the Dietary Inflammatory Index (DII) and EPLs and ESCC. As part of the National Cohort of Esophageal Cancer (NCEC) in China, 3967 residents (1993 men and 1974 women) aged from 40 to 69 years living in Yanting County received free gastroscopy screenings from 2017 to 2019. Dietary intake during the past year was assessed at enrollment of the cohort before screening and DII scores were calculated based on 28 food parameters. EPLs (classified into mild, moderate, and severe dysplasia) and ESCC were histologically confirmed by biopsy. Multivariable logistic regression was used to examine the associations of DII scores with EPLs and ESCC. A total of 312 participants were diagnosed with EPLs (226 with mild dysplasia, 40 with moderate dysplasia, and 46 with severe dysplasia) and 72 were diagnosed with ESCC. A statistically significant positive association was observed between DII scores and overall EPLs (ORT3 vs. T1 = 1.45, 95%CI = 1.01–2.09); the association was similar but not statistically significant for mild dysplasia (ORone-unit-increment = 1.11, 95%CI = 0.95–1.34) and for moderate and severe dysplasia combined (ORone-unit-increment = 1.15, 95%CI = 0.87–1.51). The association with ESCC was similar in magnitude but not significant, likely due to the small number of cases. In this cross-sectional study of a population in China at high risk of ESCC, DII scores were positively associated with odds of EPLs and ESCC. Consumption of anti-inflammatory foods may be beneficial to prevent EPLs and ESCC.
Chinese Sumac Fruits (Rhus chinesis Mill.) Alleviate Type 2 Diabetes in C57BL/6 Mice through Repairing Islet Cell Functions, Regulating IRS-1/PI3K/AKT Pathways and Promoting the Entry of Nrf2 into the Nucleus
Authors: Liu Xiaojing , Cai Shengbao , Yi Junjie , Chu Chuanqi 
Published: September 2023

This research aimed to probe the potential alleviative effects of ethanol extracts of Chinese sumac (Rhus chinesis Mill.) fruits against type 2 diabetes mellitus (T2DM) in C57BL/6 mice induced by high-fat/high-fructose diet (HFFD) and streptozotocin. The results showed that the ethanol extracts could significantly regulate blood glucose levels, glycosylated hemoglobin, blood lipids, insulin, and insulin resistance, while also restoring endogenous oxidative stress. Pathological and immunohistochemical analyses revealed that the extracts partially restored the physiological function of islet cells. Furthermore, Western blotting results suggested that the extracts could regulate the protein expression in IRS-1/PI3K/AKT signaling pathway, and immunofluorescence findings demonstrated their potential to promote the translocation of Nrf2 into the nucleus. This study elucidated a novel finding that ethanol extracts derived from Chinese sumac fruits have the potential to alleviate symptoms of T2DM in mice. Moreover, these findings could offer valuable scientific insights into the potential utilization of R. chinensis fruits as nutritional supplement and/or functional food to prevent or ameliorate diabetes.
Assessing Student Support Services in Open and Distance Learning: The Case of Botswana Open University
Authors: Majaule Fidzani Agnes 
Published: September 2023

ABSTRACT
To ensure that all students studying through the open and distance learning (ODL) system have enduring learning experience and success, there is a need for a practical and effective student support system. Research in the United Kingdom and elsewhere has shown that the rate of attrition is higher in ODL when compared to the conventional systems. In an ODL environment, student support services entail academic, psychosocial, and administrative support. Botswana Open University (BOU) is no exception to having pitfalls considering the queries raised by students. This study assessed the effectiveness of student support services in an ODL institution like BOU. The researchers adopted Tinto’s Student Integration Model as their theoretical benchmark. The model states that students are more likely to remain enrolled in an institution if they become connected to the social and academic life of that institution. A qualitative design involving interviewing tutors, students, heads of departments, tutor coordinators, and the student counsellor allowed for collection of data that was thematically analysed. The findings identified challenges related to administrative, academic and psychosocial support. Based on these findings, recommendations were made to improve student support services at BOU.
Key words: Student Support Services, Open and Distance Learning, eLearning Support, Academic support, Psychosocial support, administrative support
Counseling on the Use of Lime (Citrus aurantifolia) as Pharmaceutical Preparations in the Making of Mouthwash and hand Sanitizer
Authors: Herman Herman , H. Ambo Lau Sulfiyana , Zulfiah Zulfiah 
Published: September 2023

Health services, including in the form of health counselling and traditional medicine, are one of the most elementary health service programs considering the level of the ratio of the population to the centre, health service units and health workers who do not meet the ideal balance, so a breakthrough and smart steps are needed in responding to this. I was counselling on the Use of Lime (Citrus aurantifolia) as a Pharmaceutical Preparation in the Making of Mouthwash (Mouthwash) and Hand Sanitizer ( Antibacterial Hand Sanitizer) with the aim of improving the degree of health in the mouth and using Lime as a hand sanitiser. The methods of these activities are identification of the target objectives of the training, tools and materials used, good communication methods that are easy to understand, visualisation, evaluation, and feedback so that it can be concluded that counselling on the use of Lime as a pharmaceutical preparation in the manufacture of Mouthwash and Hand Sanitizer is a concern for healthy living in the surrounding community for the better. Thus creating a healthy and prosperous society.
Multihop MIMO Full-Duplex Relay Networks with Short-Packet URLLCs
Authors: Ngo Hoang Tu , Lee Kyungchun 
Published: September 2023

<p>In this study, we investigate multihop multipleinput multiple-output (MIMO) full-duplex relay (FDR) networks with short-packet ultra-reliability and low-latency communications (uRLLCs), where transmit-antenna selection/maximumratio combining and transmit-antenna selection/selection combining are leveraged as diversity techniques. Under quasistatic Rayleigh-fading channels and the finite-blocklength theory, the end-to-end block-error rate (BLER) performance of the considered FDR is analyzed and compared with that of halfduplex relaying systems, from which the effective throughput (ETP), energy efficiency (EE), reliability, and latency are also investigated. To analyze the diversity order and gain further insights into the system design, an asymptotic BLER analysis in the high signal-to-noise ratio regime is provided. However, the derived analytical expressions contain non-elementary functions, making them intricate for practical implementations, particularly in real-time configurations. Therefore, we have introduced a deep multiple-output neural network with short execution time, low computational complexity, and highly accurate estimation to overcome this hurdle. This network can serve as an efficient tool to rapidly respond to the necessary system parameters, such as transmit power and blocklength, when the services request specific ETP, EE, reliability, and latency. To corroborate the correctness of the theoretical analysis, extensive simulation results are provided under varying impacts of system parameters.<br>
</p>
Performance Analysis of a Downlink mmWave Communication in an IRS-Based Large-scale MIMO Networks
Authors: Onal Beyza , Kabaoglu Nihat 
Published: September 2023

<p>The tremendous advances in communication technologies require next-generation communication systems to be optimally designed in terms of speed, reliability, cost, energy consumption, spectral efficiency, ecosystem compatibility, and sustainability. With these requirements in mind, this paper discusses downlink millimeter wave communication for a large-scale multiple-input multiple-output system equipped with a group of intelligent reconfigurable surfaces, one of the potential candidates for 6G wireless networks, considering 5G physical mmWave channel models. In addition to the precoder, beamformer, and combiner design of the proposed system model, the theoretical average pairwise error probability and achievable rate expressions are derived. Furthermore, an upper bound for the achievable rate is derived. Simulation results clearly show that the performance of the proposed model is close to the theoretical bounds of the performance metrics and clearly demonstrates its superiority compared to a similar model based on index modulation.</p>
DESIGUALDADE DE GÊNERO NA ATENÇÃO PRIMÁRIA À SAÚDE: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Wellington Severino Alves Mamedes  , Dinair Ferreira Machado  , Margareth Aparecida Santini de Almeida  
Published: September 2023

A violência contra a mulher, o distanciamento masculino do cuidado em saúde primário e a discriminação contra as pessoas LGBTQIA+, lésbicas, gays, bissexuais, transgênero, queer, intersexo, assexual, são expressões do construto social de gênero que estão postas como desafios aos profissionais de saúde, que devem desenvolver estratégias de enfrentamento a essas iniquidades sociais em saúde. Por outro lado, a ordem societária pautada na desigualdade de gênero cria barreiras de acesso aos serviços de saúde e consecutivamente aumentam as disparidades sociais. Este estudo objetivou identificar, na literatura, os fatores que contribuíram para a (re) produção da desigualdade de gênero no âmbito da Atenção Primária à Saúde brasileira. Para isso, foi realizada uma revisão integrativa da literatura, cuja amostra final foi composta por 40 artigos. A coleta de dados foi realizada nas bases de dados: Scientific Eletronic Library Online (SciELO) e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Os estudos foram selecionados por meio dos descritores controlados combinados com operadores booleanos: (Gender and Health OR Género y Salud OR Gênero e Saúde) AND (Primary Health Care OR Atención Primaria de Salud OR Atenção Primária à Saúde). No corpus de analise, destacou-se a prevalência dos estudos qualitativos. Os estudos evidenciaram que, nos serviços de atenção primária, a concepção de gênero é orientado por preceitos biologizantes, frutos de um modelo de atenção em saúde biomédico que além de fragmentar as ações dos profissionais de saúde, impede que haja uma abordagem sociocultural de emancipação, corroborando assim para efetivação e naturalização da desigualdade de gênero.
ESTRATEGIAS DE CREACIÓN DE VALOR COMPARTIDO PARA LA AGENDA 2030 EN GRUPOS HOTELEROS: UNA MIRADA CUALITATIVA
Authors: Claudia Carolina Lacruhy Enríquez  
Published: September 2023

El objetivo del estudio consiste en evaluar si los grupos hoteleros de Los Cabos, México efectúan estrategias de Creación de Valor compartido que inciden en la Agenda 2030 a través de la comunicación acciones en su página web corporativa. La metodología fue de enfoque cualitativo con alcance exploratorio y descriptivo; se diseñó un modelo de observación de las páginas web corporativas, con una muestra en cadena a seis grupos hoteleros que representan el 20% del sector en la región sudcaliforniana. Los principales resultados mostraron que los grupos hoteleros tienen acciones de creación de valor compartido (100%), que aportan a los ODS (100%), tiene fundaciones de apoyo para la comunidad (100%), solamente el 33% tiene una articulación directa en plan estratégico para la competitividad, y el 83% comunica acciones sociales y de sostenibilidad. Se determinaron estrategias definidas en los tres ejes de la creación de valor compartido: preconcebir los productos y mercados, redefinir la productividad en la cadena de valor, y permitir el desarrollo de clústeres locales. La Asociación de Hoteles tiene un papel clave como clúster en la coordinación de esfuerzos conjuntos para el bienestar de los visitantes y comunidad residente. Las acciones presentan una conexión de ventaja competitiva y aborda aportaciones para los siete problemas sociales en el contexto local, que son transversales a los 17 ODS, sin embargo, tienen el área de oportunidad de que no miden los avances. En conclusión, la guía de observación permitió llevar acabo un análisis sistemático de la comunicación de acciones por parte de los grupos hoteleros, facilitó la detección de buenas prácticas y áreas de oportunidad.
PULMONARY TUBERCULOSIS AS A RISK FACTOR FOR THE DEVELOPMENT OF CHRONIC GENERALIZED PERIODONTITIS
Authors: Лунина Н.А. , Великая О.В. , Олейник О.И. 
Published: September 2023

Исследование посвящено актуальной проблеме стоматологии - хроническому генерализованному пародонтиту у больных туберкулёзом лёгких. Заболевания пародонта благоприятствуют развитию и отягощают течение общесоматических заболеваний, и соответственно наоборот, предопределяя хронический генерализованный пародонтит, как злободневную медико-социальную проблему современности. При коморбидной инфекционной патологии, включая туберкулез лёгких, фронтальными воротами для инфекции является полость рта. В работе проведён анализ влияния туберкулёза лёгких на развитие хронического генерализованного пародонтита. Описаны современные стоматологические индексы, применяемые при исследовании пародонта. Исследование проводили в двух сопоставимых по полу и возрасту группах, сравнивая индексные показатели и клинические проявления пародонтита. Для определения плана диспансерного мониторинга за пациентами, у которых в анамнезе присутствуют хроническое воспаление пародонта на фоне коморбидного хронического инфекционного заболевания необходимо обращать внимание на компетентностную дифференцированную тактику, направленную на пролонгированную программу лекарственной терапии и реабилитации, которые зависят от тяжести заболевания, неудовлетворительного характера течения патологического процесса в пародонте
The study is devoted to an urgent problem of dentistry - chronic generalized periodontitis in patients with pulmonary tuberculosis. Periodontal diseases favor the development and aggravate the course of general somatic diseases, and, accordingly, vice versa, predetermining chronic generalized periodontitis as a topical medical and social problem of our time. In comorbid infectious pathology, including pulmonary tuberculosis, the oral cavity is the frontal gateway for infection. The paper analyzes the influence of pulmonary tuberculosis on the development of chronic generalized periodontitis. Modern dental indices used in the study of periodontal disease are described. The study was conducted in two groups comparable in gender and age, comparing index indicators and clinical manifestations of periodontitis. To determine the plan of dispensary monitoring of patients who have a history of chronic periodontal inflammation against the background of comorbid chronic infectious disease, it is necessary to pay attention to competence-based differentiated tactics aimed at a prolonged program of drug therapy and rehabilitation, which depend on the severity of the disease, the unsatisfactory nature of the course of the pathological process in the periodontal
Azo dye degrading bacteria and their mechanism: A review
Authors: Upadhyay Manasi , Mondal Ahana , Saha Biswajit 
Published: September 2023

Major part of the aesthetics and beauty of idols, textiles, paper, paintings industries, etc. finds its roots in the use of colours (azo compound). These synthetic dyes can not degrade easily by physical and chemical means and are toxic for the environment and animals including humans. Even if they get degraded, it becomes difficult to get rid of the secondary toxic products. Microbes especially bacteria can be used which results cheap, eco friendly and complete degradation of azo dye products without production of any secondary toxic products (or secondary products with way lesser toxicity). Also, it requires no new chemical to be added (in an attempt to degrade azo dye) in an already polluted environment, as the bacterial enzymes would do the job without requiring any other added chemicals. This review article discusses the use of bacteria for azo dye degradation, the bacterial enzymes such as laccase etc. that degrade azo dye and how they work to decolourise the dyes, the common genetic elements found in the different bacteria that can degrade azo dye. This article also includes information on future prospects and some genetically modified organism (GMO) that are being/ (can be) brought to use for dye degradation and pollution reduction.
Percepción de Riesgos y Cultura Ambiental en Profesionales y Estudiantes de la UPSE de la Provincia de Santa Elena – Ecuador
Authors: Ordóñez Villao Carlota , Salas Díaz Rodolfo Javier , Chiriboga Diva Elizalde 
Published: September 2023

El presente artículo analiza los patrones de percepción de riesgo en relación a la preocupación ambiental de los fenómenos ambientales percibidos por los estudiantes de la Universidad Estatal Peninsular de Santa Elena. Método. A través del instrumento “listado de Situaciones de Riesgo (Mikulic, 2011)”, mediante estudio exploratorio, descriptivo, considerando las variables: edad, género y nivel educativo de los participantes de una muestra pequeña (n>30), para corroborar la normalidad de la variable cualitativa, la hipótesis se sustenta en el test de normalidad de Shapiro-Wilk, donde se la plantea de la siguienteforma: Resultados. Se puede entender desde la lógica que los sectores donde viven expuestos, determinarán más la vulnerabilidad y entendimiento de percibir los fenómenos climáticos. Se halló una mayor percepción de riesgo en un área con tendencias a huracanes y tormentas 72% y 68% vivir cerca de una planta nuclear? Conclusión. Se entiende que la acción humana en su cotidianidad va percibiendo los riesgos desde un contexto sociocultural, una buena preparación anticipada permitiría tener criterios preventivos y minimizar los riesgos de impacto que estos puedan generar en el ser humano.
Asteroseismology and Spectropolarimetry of the Exoplanet Host Star λ Serpentis
Authors: Metcalfe Travis S. , Buzasi Derek , Huber Daniel , Pinsonneault Marc H. , van Saders Jennifer L. , Ayres Thomas R. , Basu Sarbani , Drake Jeremy J. , Egeland Ricky , Kochukhov Oleg , Petit Pascal , Saar Steven H. , See Victor , Stassun Keivan G. , Li Yaguang , Bedding Timothy R. , Breton Sylvain N. , Finley Adam J. , García Rafael A. , Kjeldsen Hans , Nielsen Martin B. , Ong J. M. Joel , Rørsted Jakob L. , Stokholm Amalie , Winther Mark L. , Clark Catherine A. , Godoy-Rivera Diego , Ilyin Ilya V. , Strassmeier Klaus G. , Jeffers Sandra V. , Marsden Stephen C. , Vidotto Aline A. , Baliunas Sallie , Soon Willie 
Published: September 2023

Abstract
The bright star λ Ser hosts a hot Neptune with a minimum mass of 13.6 M
⊕ and a 15.5 day orbit. It also appears to be a solar analog, with a mean rotation period of 25.8 days and surface differential rotation very similar to the Sun. We aim to characterize the fundamental properties of this system and constrain the evolutionary pathway that led to its present configuration. We detect solar-like oscillations in time series photometry from the Transiting Exoplanet Survey Satellite, and we derive precise asteroseismic properties from detailed modeling. We obtain new spectropolarimetric data, and we use them to reconstruct the large-scale magnetic field morphology. We reanalyze the complete time series of chromospheric activity measurements from the Mount Wilson Observatory, and we present new X-ray and ultraviolet observations from the Chandra and Hubble space telescopes. Finally, we use the updated observational constraints to assess the rotational history of the star and estimate the wind braking torque. We conclude that the remaining uncertainty on the stellar age currently prevents an unambiguous interpretation of the properties of λ Ser, and that the rate of angular momentum loss appears to be higher than for other stars with a similar Rossby number. Future asteroseismic observations may help to improve the precision of the stellar age.
Visual Orbits and Alignments of Planet-hosting Binary Systems
Authors: Lester Kathryn V. , Howell Steve B. , Matson Rachel A. , Furlan Elise , Gnilka Crystal L. , Littlefield Colin , Ciardi David R. , Everett Mark E. , Fajardo-Acosta Sergio B. , Clark Catherine A. 
Published: September 2023

Abstract
Roughly half of Solar-type planet hosts have stellar companions, so understanding how these binary companions affect the formation and evolution of planets is an important component to understanding planetary systems overall. Measuring the dynamical properties of planet host binaries enables a valuable test of planet formation in multistar systems and requires knowledge of the binary orbital parameters. Using high-resolution imaging, we have measured the relative astrometry and visual orbits of 13 binary systems where one of the stars is known to host a transiting exoplanet. Our results indicate that the mutual inclination between the orbits of the binary hosts and the transiting planets are well aligned. Our results for close binary systems (a < 100 au) complement past work for wide planet host binaries from Gaia.