bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological and metabolomic analysis reveals maturity stage-dependent nitrogen regulation of vitamin C content in pepper fruit
Authors: Zhang Lu , Zhang Fen , Wang Yuan , Ma Xiao , Shen Yuanpeng , Wang Xiaozhong , Yang Huaiyu , Zhang Wei , Lakshmanan Prakash , Hu Yuncai , Xu Jiuliang , Chen Xinping , Deng Yan 
Published: January 2023

Pepper is one of the most vitamin C enriched vegetables worldwide. Although applying nitrogen (N) fertilizer is an important practice for high fruit yield in pepper production, it is still unclear how N application regulates pepper fruit vitamin C anabolism at different maturity stage. To further the understanding, we combined physiological and metabolomic analysis to investigate the fruit vitamin C content (including ascorbic acid (AsA) and dehydroascorbic acid (DHA)), related enzyme activity and non-targeted metabolites of field-grown chili pepper produced under different N levels at mature green and red stages. The results showed that increasing N application reduced AsA content in pepper fruit at both maturity stages, but highly elevated DHA content only at mature green stage. Regardless of N application level, AsA content displayed an increasing trend while DHA content was reduced as pepper fruit maturity advanced, resulting in a higher content of total vitamin C at the mature green stage. The L-galactose pathway, D-galacturonate pathway, and myo-inositol pathway were identified for AsA biosynthesis. The involved precursor metabolites were mainly negatively regulated by increasing N application, and their accumulation increased when pepper fruit developed from green to red stage. Meanwhile, the activities of key enzymes and metabolites in relation to degradation and recycling processes of AsA and DHA were increased or did not change with increasing N application, and they were differently influenced as fruit maturing. As a result, the recommended N application level (250 kg N ha-1) could maintain relatively high total vitamin C content in pepper fruits without yield loss at both maturity stages. These findings highlight the importance of optimizing N application level to maximize vitamin C content in pepper fruits, and provide a better understanding of the maturity stage-dependent N regulation on vitamin C anabolism.
How does mathematical modeling competency affect the creativity of middle school students? The roles of curiosity and guided inquiry teaching
Authors: Wang Tian , Zhang Libin , Xie Zhiyong , Liu Jian 
Published: January 2023

IntroductionMathematical modeling has become a crucial competence in mathematics education in many countries and regions due to the increasingly complex real-world problems that students face in the 21st century. Previous research has shown that mathematical modeling contributes to the development of students’ creativity, particularly with respect to stimulating and protecting the curiosity of children. However, previous studies have not explored or examined the relationships among middle school students’ mathematical modeling competency, curiosity, and creativity based on data drawn from large-scale assessments and have not investigated the influence of teachers’ teaching methods in this context.MethodsThis study used convenience sampling to select 4,531 seventh-grade students from eastern and western, urban and rural areas in China. Online tests and questionnaires were used to measure their mathematical modeling competency, curiosity, creativity and guided inquiry teaching, and a moderated mediation model was used to analyze the effect of mathematical modeling competency on creativity.ResultsThe results showed the following. (1) There are statistically significant differences between boys and girls in terms of their mathematical modeling competency, curiosity, and creativity. Specifically, boys score significantly higher than girls on these variables. (2) Creativity exhibits a statistically significant positive correlation with mathematical modeling competency, curiosity, and guided inquiry teaching. (3) Curiosity mediates the relationship between mathematical modeling competency and creativity, and guided inquiry teaching moderates the influence of curiosity. In high-level guided inquiry teaching classes, curiosity has a stronger influence on creativity, and it mediates the relationship between mathematical modeling competency and creativity more strongly.DiscussionThis study empirically verified the influence of mathematical modeling competency on creativity and provided a possible way to cultivate children’s creativity. Future research should use longitudinal analysis to verify the causal relationship between mathematical modeling competency and creativity and to systematically explore the possible path by which mathematical modeling competency affects creativity.
Promotion mechanism of high-involvement human resource management practices to employees’ bootlegging: A moderated mediation model
Authors: Jia Jianfeng , Liu Zhi , Liu Weipeng , Hu Jieli 
Published: January 2023

IntroductionBootlegging is a frontier topic in micro-innovation literature. Existing research on the external environment-antecedents of employees’ bootlegging focuses mainly on organizational innovation management practices and leadership. The relationship between human resource management and employees’ bootlegging is still unclear. Thus, we follow the stimuli-organism-response model and use psychological ownership theory to examine a moderated mediation model with psychological ownership as a mediator and Chinese traditionality as a moderator to interpret how and when high-involvement human resource management practices influence employees’ bootlegging.MethodsWe administered three-wave time-lagged surveys to 251 employees and used SEM analysis to test the hypotheses.ResultsThe results show that high-involvement human resource management practices is positively related to employees’ psychological ownership. Whereas psychological ownership, in turn, positively related to bootlegging. Meanwhile, employees’ psychological ownership plays a significant mediating role between high-involvement human resource management practices and employees’ bootlegging. The results further showed that employees’ Chinese traditionality weakens the influence of psychological ownership on bootlegging and the mediating effect of employees’ psychological ownership between high-involvement human resource management practices and employees’ bootlegging.DiscussionThis study makes several contributions to the bootlegging antecedent mechanism research. Specifically, it expands the understanding of the antecedents of bootlegging from a new perspective of human resource management, enriches the bootlegging-promotive cognition path from the perspective of psychological ownership, and enriches the proximal boundary in bootlegging antecedent mechanism from the perspective of individual personality. This study also inspires enterprises in innovation and talent management.
Psychological birth trauma: A concept analysis
Authors: Sun Xiaoqing , Fan Xuemei , Cong Shengnan , Wang Rui , Sha Lijuan , Xie Hongyan , Han Jingjing , Zhu Zhu , Zhang Aixia 
Published: January 2023

AimTo define and analyze the concept of psychological birth trauma.DesignThe concept analysis method of Walker and Avant was used.MethodEight databases (PubMed, CINAHL Complete, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang, VIP Information Chinese Journal Service Platform, and Chinese BioMedicine Literature Database) were searched from inception to July 2022 for studies focused on psychological birth trauma.ResultsOf the 5,372 studies identified, 44 ultimately met the inclusion criteria. The attributes identified were (1) women’s subjective feelings, (2) intertwined painful emotional experiences, (3) originating in the birth process, and (4) lasting until postpartum. Antecedents were divided into two groups: pre-existing antecedents and birth-related antecedents. Consequences were identified as negative and positive.ConclusionPsychological birth trauma is a more complex and comprehensive concept than previously thought, and should be regarded as a separate postpartum mental health problem. This study deepens the understanding of psychological birth trauma through a comprehensive concept analysis and also puts forward some suggestions for the prevention, identification, and intervention of psychological birth trauma, which provides a basis for assisting in the identification of psychological birth trauma and provides a reference for the development of rigorous assessment tools and the design of appropriate interventions in the future. Further research is needed to update and refine this concept.
Understanding the influencing mechanism of users’ participation in live streaming shopping: A socio-technical perspective
Authors: Dong Xueyan , Liu Xu , Xiao Xuan 
Published: January 2023

IntroductionIn live streaming shopping, exploring the influencing mechanism of consumers’ participation is an important prerequi site for understanding consumer behavior in social commerce activities. The purpose of this study is to explore the relationship betw een technological and social factors (visibility, media richness, guidance shopping and real-time interactivity) in live streaming shop ping and consumers’ purchase intention. The mediating roles of attraction and cognitive assimilation were also examined.MethodsThis study collected 425 pieces of data through questionnaire survey. The structural equation model is established based on S-O-R frame. The hypothesis is tested by structural equation model.ResultsOur study found that that real-time interactive and media richness positively affect attraction; visibility, guidance shopping and media richness positive affect cognitive assimilation; cognitive assimilation and attraction positive affect consumers’ purchase intention; cognitive assimilation and attraction play a partial mediating role in the influence of technology and social factors on cons umers’ purchase intention of live streaming shopping.DiscussionFrom the perspective of socio-technical, this study explores the influence mechanism of different influencing factors on consumers’ purchase intention in live streaming shopping. This study expands the application of IT affordance theory in the context of live streaming shopping, and reveals the mediating role of attraction and cognitive assimilation between social, technological factors and consumers’ purchase intention.
P300 event-related potentials in patients with different subtypes of depressive disorders
Authors: Wang Yun , Li Canxin , Liu Xiaohua , Peng Daihui , Wu Yan , Fang Yiru 
Published: January 2023

ObjectiveTo explore the differences in event-related potentials (ERPs) of the subclinical types of major depressive disorders (MDD): melancholic (MEL), atypical (ATY), and anxious (ANX).MethodsPatients with MDD treated in the Clinical Department of Shanghai Mental Health Center between September 2017 and December 2020 were prospectively included. This study was approved by the Ethics Committee of the Shanghai Mental Health Center. They were evaluated using the Mini-International Neuropsychiatric Interview (MINI), 17-item Hamilton Depression Scale (HAMD-17), 30-item Self-rated Inventory of Depressive Symptomatology (IDS-30SR), 16-item Quick Inventory of Negative Symptom Scale (QIDS-16SR), and auditory and visual P300 ERPs.ResultsFinally, 27, 14, and 20 patients with MEL, ATY, and ANX MDD were included in this study, respectively. There were no significant differences in demographic characteristics and HAMD-17, IDS-30SR, and QIDS-16SR total scores among the three groups (all P &gt; 0.05). On the C3 lead, the latency for patients with MEL MDD was the longest, and the latency for patients with ATY MDD was the shortest (MEL vs. ATY vs. ANX: 373.89 ± 6.60 vs. 344.79 ± 9.78 vs. 359.33 ± 7.62, P = 0.039). On the Pz lead, the latency for patients with MEL MDD was the longest, and the latency for patients with ATY MDD was the shortest (MEL vs. ATY vs. ANX: 376.14 ± 6.51 vs. 347.21 ± 9.42 vs. 362.22 ± 8.63, P = 0.047). There were no differences in visual P300 ERPs among the three groups.ConclusionThere are significant differences in auditory C3 and Pz latency among MEL, ATY, and ANX MDD. These differences could help diagnose the subtype of MDD.
Determinants and prediction of Chlamydia trachomatis re-testing and re-infection within 1 year among heterosexuals with chlamydia attending a sexual health clinic
Authors: Xu Xianglong , Chow Eric P. F. , Fairley Christopher K. , Chen Marcus , Aguirre Ivette , Goller Jane , Hocking Jane , Carvalho Natalie , Zhang Lei , Ong Jason J. 
Published: January 2023

BackgroundChlamydia trachomatis (chlamydia) is one of the most common sexually transmitted infections (STI) globally, and re-infections are common. Current Australian guidelines recommend re-testing for chlamydia 3 months after treatment to identify possible re-infection. Patient-delivered partner therapy (PDPT) has been proposed to control chlamydia re-infection among heterosexuals. We aimed to identify determinants and the prediction of chlamydia re-testing and re-infection within 1 year among heterosexuals with chlamydia to identify potential PDPT candidates.MethodsOur baseline data included 5,806 heterosexuals with chlamydia aged ≥18 years and 2,070 re-tested for chlamydia within 1 year of their chlamydia diagnosis at the Melbourne Sexual Health Center from January 2, 2015, to May 15, 2020. We used routinely collected electronic health record (EHR) variables and machine-learning models to predict chlamydia re-testing and re-infection events. We also used logistic regression to investigate factors associated with chlamydia re-testing and re-infection.ResultsAbout 2,070 (36%) of 5,806 heterosexuals with chlamydia were re-tested for chlamydia within 1 year. Among those retested, 307 (15%) were re-infected. Multivariable logistic regression analysis showed that older age (≥35 years old), female, living with HIV, being a current sex worker, patient-delivered partner therapy users, and higher numbers of sex partners were associated with an increased chlamydia re-testing within 1 year. Multivariable logistic regression analysis also showed that younger age (18–24 years), male gender, and living with HIV were associated with an increased chlamydia re-infection within 1 year. The XGBoost model was the best model for predicting chlamydia re-testing and re-infection within 1 year among heterosexuals with chlamydia; however, machine learning approaches and these self-reported answers from clients did not provide a good predictive value (AUC &lt; 60.0%).ConclusionThe low rate of chlamydia re-testing and high rate of chlamydia re-infection among heterosexuals with chlamydia highlights the need for further interventions. Better targeting of individuals more likely to be re-infected is needed to optimize the provision of PDPT and encourage the test of re-infection at 3 months.
Short-term efficacy of non-pharmacological interventions for global population with elevated blood pressure: A network meta-analysis
Authors: Shao Taihang , Liang Leyi , Zhou Chengchao , Tang Yaqian , Gao Wenqing , Tu Yusi , Yin Yue , Malone Daniel C. , Tang Wenxi 
Published: January 2023

BackgroundThis study aims to compare the potential short-term effects of non-pharmacological interventions (NPIs) on prehypertensive people, and provide evidence for intervention models with potential in future community-based management.MethodsIn this Bayesian network meta-analysis, Pubmed, Embase, and Web of science were screened up to 16 October 2021. Prehypertensive patients (systolic blood pressure, SBP 120–139 mmHg/diastolic blood pressure, DBP 80–89 mmHg) with a follow-up period longer than 4 weeks were targeted. Sixteen NPIs were identified during the scope review and categorized into five groups. Reduction in SBP and DBP was selected as outcome variables and the effect sizes were compared using consistency models among interventions and intervention groups. Grade approach was used to assess the certainty of evidence.ResultsThirty-nine studies with 8,279 participants were included. For SBP, strengthen exercises were the most advantageous intervention group when compared with usual care (mean difference = −6.02 mmHg, 95% CI −8.16 to −3.87), and combination exercise, isometric exercise, and aerobic exercise were the three most effective specific interventions. For DBP, relaxation was the most advantageous intervention group when compared with usual care (mean difference = −4.99 mmHg, 95% CI −7.03 to −2.96), and acupuncture, meditation, and combination exercise were the three most effective specific interventions. No inconsistency was found between indirect and direct evidence. However, heterogeneity was detected in some studies.ConclusionNPIs can bring short-term BP reduction benefits for prehypertensive patients, especially exercise and relaxation. NPIs could potentially be included in community-based disease management for prehypertensive population once long-term real-world effectiveness and cost-effectiveness are proven.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=151518, identifier: CRD42020151518.
Socio-demographic and geographic disparities of population-level food insecurity during the COVID-19 pandemic in Thailand
Authors: Phulkerd Sirinya , Thongcharoenchupong Natjera , Chamratrithirong Aphichat , Gray Rossarin Soottipong , Pattaravanich Umaporn , Ungchusak Chantana , Saonuam Pairoj 
Published: January 2023

IntroductionThis study investigated the prevalence of food insecurity, and the association between socio-demographic and geographic factors and food insecurity in Thailand during the COVID-19 pandemic.MethodsThe study extracted data on 5,066 persons age 15 years or older from a nationally-representative sample survey of Thai households, conducted during June-December 2021. The respondents were asked about food insecurity, socio-demographic characteristics, debt, and role of the primary household food provider. Binary logistic regression analysis was used to investigate the association between the variables and food insecurity.ResultsOf the total sample, 28.6% had food insecurity. The highest probability of having food insecurity (p &lt; 0.001) was observed in persons age 15–29 years, with no formal education, and in the lowest quartile of income. The highest probability of having food insecurity was found among respondents residing in the northeast, which is the poorest and with the least development status among geographic regions in Thailand. Respondents who reported having onerous personal debt and being the main household food provider were 1.4 and 2.3 times as likely to have food insecurity as those with no debt and not being the main food provider, respectively (p &lt; 0.001).ConclusionThis suggests that government attention is required in developing policies and strategies to improve food security through addressing the socio-economic determinants, and buffer the negative impact of a national crisis on diets. Investment to improve household income and raise the educational profile of the population is needed. Addressing the regional disparities in food security requires area-specific measures which target the most vulnerable population groups.
The role of CRYAB in tumor prognosis and immune infiltration: A Pan-cancer analysis
Authors: Cheng Lang , Zou Xiong , Wang Jiawei , Zhang Jiange , Mo Zengnan , Huang Houbao 
Published: January 2023

PurposeThere is evidence that the Crystallin Alpha B (CRYAB) gene is involved in the regulation of the tumor microenvironment and influences tumor prognosis in some cancers. However, the role of CRYAB gene in prognosis and immunology in pan-cancer is still unclear.MethodsIn this study, we analyzed the transcriptional profiles and survival data of cancer patients from The Cancer Genome Atlas (TCGA) database. CRYAB gene and its relationships with pan-cancer were analyzed using R packages, TIMER2.0, GEPIA2, Sangerbox, UALCAN, cBioPortal, ESTIMATE algorithm, and STRING. Besides, real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) was utilized to detect CRYAB expression in KIRC and a human KIRC cell line (Caki-1).ResultsWe found that CRYAB expression was different in tumors and adjacent tumors in human cancers, affecting patients’ prognosis in 15 cancer types. Additionally, CRYAB expression significantly correlated with tumor microenvironment (TME), immune checkpoints (ICP), tumor mutational burden (TMB), and microsatellite instability (MSI) in human cancers. Besides, CRYAB expression was positively associated with the immune infiltration of cancer-associated fibroblasts (CAFs) and endothelial cells in most human cancers. Based on enrichment analysis, the most prevalent CRYAB gene mechanism in malignant tumors may be through anti-apoptotic activity. Moreover, some FDA-approved drugs were found to be associated with CRYAB and might be potential cancer therapeutic candidates.ConclusionsCRYAB is a crucial component of the TME and influences immune cell infiltration, making it a promising biomarker to assess immune infiltration and prognosis in many malignancies.
Efficacy of autologous mesenchymal stromal cell treatment for chronic degenerative musculoskeletal conditions in dogs: A retrospective study
Authors: Armitage Andrew J. , Miller Joanna M. , Sparks Tim H. , Georgiou Alex E. , Reid Jacqueline 
Published: January 2023

IntroductionThe objective of this study was to retrospectively analyze clinical data from a referral regenerative medicine practice, to investigate the efficacy of autologous mesenchymal stromal cells (MSC) in 245 dogs deemed unresponsive to conventional treatment by their referring vet.MethodsDiagnostic imaging [radiology and musculoskeletal ultrasound (MSK-US)] identified musculoskeletal pathology holistically. MSCs, produced according to current guidelines, were initially administered with PRP by targeted injection to joints and/or tendons, with a second MSC monotherapy administered 12 weeks later to dogs with severe pathology and/or previous elbow arthroscopic interventions. Dogs with lumbosacral disease received epidural MSCs with additional intravenous MSCs administered to dogs with spondylosis of the cervical, thoracic and lumbar spine. All dogs received laser therapy at 10 J/cm2at the time of treatment and for 5 sessions thereafter. Objective outcome measures (stance analysis, range of joint motion, pressure algometry) and validated subjective outcome measures (owner reported VetMetrica HRQL™ and veterinary pain and quality of life impact scores) were used to investigate short and long-term (6–104 weeks) efficacy. Outcome data were collected at predetermined time windows (0–6, 7–12, 13–18, 19–24, 25–48, 49–78, 79–104) weeks after initial treatment.ResultsThere were statistically significant improvements in post compared with pre-treatment measures at all time windows in stance analysis, shoulder and hip range of motion, lumbosacral pressure algometry, and to 49–78 weeks in carpus and elbow range of motion. Improvements in 4 domains of quality of life as measured by VetMetricaTM were statistically significant, as were scores in vet-assessed pain and quality of life impact. In dogs receiving one initial treatment the mean time before a second treatment was required to maintain improvements in objective measures was 451 days. Diagnostic imaging confirmed the regenerative effects of MSCs in tendinopathies by demonstrating resolution of abnormal mineralization and restoration of normal fiber patterns.DiscussionThis represents the first study using “real-world” data to show that cell-based therapies, injected into multiple areas of musculoskeletal pathology in a targeted holistic approach, resulted in rapid and profound positive effects on the patient's pain state and quality of life which was maintained with repeat treatment for up to 2 years.