bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of MicroRNA for Pancreatic Cancer Screening in Patients With Diabetes
Authors: Kowada Akiko 
Published: January 2023

Objectives
The study aimed to assess the cost-effectiveness of microRNA compared with carbohydrate antigen 19-9, abdominal ultrasound, magnetic resonance imaging, endoscopic ultrasound, computed tomography, positron emission tomography, and no screening for pancreatic cancer (PC) screening in patients with diabetes.

Methods
We developed a state-transition model from a health care payer perspective and a lifetime horizon. We targeted 3 hypothetical cohorts of patients with long-standing type 2 diabetes (LSD), new-onset diabetes (NOD), and LSD having intraductal papillary mucinous neoplasm (IPMN), aged 40, 50, 60, and 70 years. The main outcomes were costs, quality-adjusted life-years, life expectancy life-years, incremental cost-effectiveness ratios, and deaths from PC.

Results
In the base-case analysis, abdominal ultrasound in patients with LSD and microRNA in patients with NOD and LSD having IPMN were the most cost-effective for all age groups. Cost-effectiveness was sensitive to PC incidence and the cost of microRNA. Probabilistic sensitivity analysis showed that microRNA was 42% to 54% cost-effective for NOD and 76% to 78% cost-effective for LSD having IPMN at a willingness-to-pay level of US $100,000 per quality-adjusted life-year gained. MicroRNA prevented 30,641 PC deaths in diabetic patients compared with no screening.

Conclusions
In patients with NOD and LSD having IPMN, microRNA-based PC screening is cost-effective and recommended for early PC detection.
Macronutrients Not Micronutrients Are Associated With the Risk of Pancreatic Cancer
Authors: Tayyem Reema F. , Ibrahim Mohammed O. , Abuhijleh Haya , Alatrash Razan M. , Al-Jaberi Tareq , Hushki Ahmad , Albtoush Yazan , Yacoub Shirin , Allehdan Sabika 
Published: January 2023

Objectives
Pancreatic cancer (PC) has been related directly to many risk factors; however, diet is considered one of the most modifiable risk factors. This study is designed to observe the associations between the intake of macromicronutrients and the risk of pancreatic cancer in a Jordanian population.

Methods
A case-control study included 100 patients with the incident and histologically confirmed PC and 309 control subjects frequency-matched on age, educational level, occupation, and marital status. Face-to-face interview was used to collect the study's sociodemographic, physical activity, and dietary information. Intakes of macronutrients and micronutrients were assessed by a validated food-frequency questionnaire. Multinomial logistic regression was used to calculate odds ratios and confidence intervals.

Results
The patients reported higher consumption of almost all the macromicronutrients and micronutrients as compared with control subjects. The highest tertile of dietary intake of carbohydrates, sugars, fats, saturated fats, monounsaturated fats, trans fats, cholesterol, and vitamin B3 was positively associated with PC risk (P
trend < 0.05). However, dietary intakes of polyunsaturated fats, omega-3, and some vitamins and minerals were not associated (P
trend > 0.05) with the risk of PC.

Conclusions
Our findings support the positive role of proteins, carbohydrates, sugars, fats, saturated fats, monounsaturated fats, trans fats, and cholesterol on pancreatic carcinogenesis.
Role of Chromogranin A in the Diagnosis and Follow-up of Neuroendocrine Tumors
Authors: Nguyen Mike , Li Michelle , Travers Avraham , Segelov Eva 
Published: January 2023

Objective
The aim of this study was to assess the utility of serum chromogranin A (CgA) along the clinical pathway of patients with neuroendocrine tumors (NETs).

Methods
A retrospective review of medical records was conducted of patients with NET who had at least 1 measurement of CgA between January 2015 and April 2021 at a large metropolitan Australian hospital. Chromogranin A was classified as increased or decreased if there was at least a 25% change in sequential levels and was compared with disease response by anatomical or functional imaging if within 6 weeks (considered concurrent).

Results
Of 102 patients with NETs, 67 had at least 1 serum CgA level: 50 had been ordered during diagnostic workup, of which 33 were elevated (sensitivity: 66%; 95% confidence interval, 51%–79%). Of 129 CgA results concurrent with imaging, the sensitivity for detecting progressive disease was 28% (95% confidence interval, 15%–44%).

Conclusions
Our findings support previous concerns that CgA adds little value in clinical decision-making.
Diagnostic Yield of Serial Pancreatic Juice Aspiration Cytologic Examination With Brush Cytology for Pancreatic Ductal Stenosis
Authors: Mie Takafumi , Sasaki Takashi , Takeda Tsuyoshi , Okamoto Takeshi , Mori Chinatsu , Furukawa Takaaki , Yamada Yuto , Kasuga Akiyoshi , Matsuyama Masato , Ozaka Masato , Sasahira Naoki 
Published: January 2023

Objectives
Serial pancreatic-juice aspiration cytologic examination (SPACE) is useful for diagnosis of pancreatic ductal stenosis. This study investigates the utility of adding brush cytology to SPACE during the same procedure.

Methods
We retrospectively analyzed consecutive patients who underwent SPACE with brush cytology for pancreatic ductal stenosis between February 2014 and July 2020 in our hospital.

Results
Thirty-four patients were included. Eleven had lesions in the pancreatic head lesions, and 23 had lesions in the pancreatic body or tail. Malignancies were found in 22 patients. Endoscopic ultrasound, computed tomography, and magnetic resonance imaging showed distal pancreatic duct dilation in 81.8% to 90.6% of cases, with a sensitivity of 63.0% to 65.5%. The sensitivity and diagnostic accuracy of SPACE, brush cytology, and SPACE with brush cytology were 63.6%, 50.0%, and 77.3% (P = 0.19) and 73.5%, 67.6%, and 82.4% (P = 0.42), respectively. No significant differences in diagnostic yield were observed for either pancreatic head lesions or pancreatic body/tail lesions. Post–endoscopic retrograde cholangiopancreatography pancreatitis was observed in 4 cases (11.8%).

Conclusions
The utility of adding brush cytology to SPACE was limited.
The Association Between Pancreatic Steatosis and Metabolic Syndrome
Authors: Bi Ye , Lin Hai-Yan , Li Ming-Long , Zhou Jie , Sun Xiang-Lan 
Published: January 2023

Objectives
To date, the complete natural history of pancreatic steatosis is unknown. This study aimed to investigate the association of fatty pancreas (FP) in the incidence of metabolic syndrome and its components among Chinese patients with a 5-year follow-up.

Methods
Three independent cross-sectional surveys were carried out in 2013, 2015, and 2018. Fatty pancreas was diagnosed via transabdominal sonography. Logistic regression analysis was used to estimate the correlation between FP and metabolic syndrome. New cases of metabolic syndrome and its components were estimated by Cox proportional hazards models.

Results

At baseline, 12,551 individuals classified into FP (n = 1010) and non-FP (n = 11,541) groups were finally enrolled. In cross-sectional analyses, odds ratio of FP was 2.378 (95% confidence interval [CI], 2.085–2.713; P < 0.001). In longitudinal analyses, FP was associated with the occurrence of metabolic syndrome (hazard ratio [HR], 3.179; 95% CI, 2.197–4.6; P < 0.001), type 2 diabetes mellitus (HR, 13.99; 95% CI, 7.865–24.883; P < 0.001), nonalcoholic fatty liver disease (HR, 31.843; 95% CI, 7.73–131.171; P < 0.001), and hypertension (HR, 12.801; 95% CI, 7.323–22.38; P < 0.001).

Conclusions
Pancreatic steatosis is strongly associated with the occurrence of metabolic syndrome and its components such as hypertension and diabetes.
Development and Validation of 18F-FDG PET/CT-Based Models for Predicting Successful Complete Cytoreduction During Primary Cytoreductive Surgery for Advanced Ovarian cancer
Authors: Kim Junhwan , Gil Joonhyung , Kim Se Ik , Hwangbo Suhyun , Noh Joseph J. , Lee Jeong-Won , Cheon Gi Jeong , Kim Jae-Weon , Cho Young Seok , Lee Maria 
Published: January 2023

Purpose
The aim of this study was to develop an 18F-FDG PET/CT-based model to predict complete cytoreduction during primary cytoreductive surgery (CRS) for ovarian cancer (OC).

Patients and Methods
We retrospectively identified patients with stage III–IV OC who underwent primary CRS between June 2013 and February 2020 at 2 tertiary centers. Patients from each hospital were assigned to training and test sets. The abdominal cavity was divided into 3 sections, and data for the PET/CT-derived parameters were collected through image analysis. Various prediction models were constructed by combining clinicopathologic characteristics and PET/CT-derived parameters. The performance of the model with the highest area under the receiver operating characteristic curve (AUC) was externally validated.

Results
The training and test sets included 159 and 166 patients, respectively. The median age of patients in the test set was 55 years; 72.3% of them had stage III tumors, and 65.4% underwent complete cytoreduction. Metabolic tumor volume, total lesion glycolysis, and the number of metastatic lesions above the upper margin of the renal vein (area A) were selected among the PET/CT parameters. The best predictive multivariable model consisted of CA-125 (<750 or ≥750 IU/mL), number of metastatic lesions (<2 or ≥2), and metabolic tumor volume of area A, predicting complete cytoreduction with an AUC of 0.768. The model was validated using a test set. Its predictive performance yielded an AUC of 0.771.

Conclusions
We successfully developed and validated a preoperative model to predict complete cytoreduction in advanced OC. This model can facilitate patient selection for primary CRS in clinical practice.
Comparison of the Detection Performance Between FAP and FDG PET/CT in Various Cancers
Authors: Chang Wen-Yi , Tseng Neng-Chuan , Chen Li-Yu , Chang Chi-Wei , Huang Ya-Yao , Huang Ya-Ting , Ou Yen-Chuan , Peng Nan-Jing 
Published: January 2023

Purpose18F-FDG is the dominant radiotracer in oncology; however, it has limitations. Novel labeled fibroblast activation protein (FAP) radiotracers have been developed and published in several studies. Thus, this meta-analysis aimed to compare the detection rates (DRs) of FDG and FAP, based on previous studies from a systematic review.MethodsPubMed/MEDLINE and Cochrane library databases were used to perform a comprehensive and systematic search and are updated to April 30, 2022. The DR, relative risk, and the SUVmaxwere calculated between the FAP and FDG tracers. Finally, the sensitivity, specificity, diagnostic odds ratio, and summary receiver operating characteristic curve of FAP and FDG were analyzed using gold and reference standards.ResultsThirty studies (1170 patients) were included in the meta-analysis. The relative risks of FAP DR for the primary tumor, recurrent tumor, lymph node metastasis, and distant metastasis were FDG 1.06- to 3.00-fold per patient and per lesion. For the primary tumor, FAP uptake was most intense in pancreatic cancer, followed by head and neck, cervical, colorectal, lung, gastric, and hepatocellular carcinoma, and was higher than FDG except for urological system cancer. The sensitivity (0.84–0.98), diagnostic odds ratio (19.36–358.47), and summary receiver operating characteristic curve (0.94–0.99) of FAP based on patient and lesion were better for primary tumors, LN metastasis, and distant metastasis than FDG.ConclusionsFibroblast activation protein is an extremely potential radiotracer to replace most of the use of FDG in oncology. It is noteworthy that the FAP tracers for primary tumors had low specificity despite excellent sensitivity and had lower uptake than FDG in urological system cancer. In addition, the difference in detection between FAP and FDG for LN metastasis could not be certain in sarcoma.
Incidental Finding of a Tongue Schwannoma Mimicking Local Recurrence of Squamous Cell Carcinoma on a Systematic Follow-up 18F-FDG PET/CT
Authors: Dzuko Kamga Jacques , Leclere Jean-Christophe , Conan-Charlet Virginie , Tissot Valentin , Abgral Ronan 
Published: January 2023

Abstract
Schwannomas are usually benign, rare, and slow-growing nerve sheath tumor composed of Schwann cells. They develop in the head and neck area in approximately 25% to 40% of cases, of which 1% in the oral cavity, where the tongue remains the preferred site. Malignant transformation occurs in approximately 8% to 10% cases. We report a unique case of a histologically proven FDG-avid schwannoma of the left mobile portion of the tongue, showing an 18F-FDG avidity on PET/CT, which was a false-positive result for local recurrence in a patient followed for squamous cell carcinoma.
Hypermetabolic Subserosal Uterine Leiomyoma With Synchronous Atypical Multiple Myeloma Mimicking Ovarian Malignancy With Multiple Bone Metastases on 18F-FDG PET/CT
Authors: Yao Xilan , Liu Weiting , Ou Xiaohong 
Published: January 2023

Abstract
Subserosal cystic myoma with intense FDG uptake can resemble malignant cystic ovarian tumor and may lead to a false-positive diagnosis. A 49-year-old woman presented with chest pain for 4 months, and the initial chest CT showed multiple bone lesions. 18F-FDG PET/CT revealed not only multiple osteolytic lesions with FDG uptake but also a highly FDG-avid mass abutting the right side of the uterus. Ovarian malignancy with multiple bone metastases was considered initially. Subsequent biopsy confirmed multiple myeloma, and a subserosal uterine myoma was diagnosed by transvaginal sonography.
Placing approach-avoidance conflict within the framework of multi-objective reinforcement learning
Authors: Enkhtaivan Enkhzaya , Nishimura Joel , Cochran Amy 
Published: January 2023

AbstractMany psychiatric disorders are marked by impaired decision-making during an approach-avoidance conflict. Current experiments elicit approachavoidance conflicts in bandit tasks by pairing an individual’s actions with consequences that are simultaneously desirable (reward) and undesirable (harm). We frame approach-avoidance conflict tasks as a multi-objective multi-armed bandit. By defining a general decision-maker as a limiting sequence of actions, we disentangle the decision process from learning. Each decision maker can then be identified as a multi-dimensional point representing its long-term average expected outcomes, while different decision making models can be associated by the geometry of their ‘feasible region’, the set of all possible long term performances on a fixed task. We introduce three example decision-makers based on popular reinforcement learning models and characterize their feasible regions, including whether they can be Pareto optimal. From this perspective, we find that existing tasks are unable to distinguish between the three examples of decision-makers. We show how to design new tasks whose geometric structure can be used to better distinguish between decision-makers. These findings are expected to guide the design of approach-avoidance conflict tasks and the modeling of resulting decision-making behavior.
The Resolvin D2-GPR18 Axis Enhances Bone Marrow Function and Limits Hepatic Fibrosis in Aging
Authors: Fitzgerald Hannah , Bonin Jesse L. , Sadhu Sudeshna , Lipscomb Masharh , Biswas Nirupam , Decker Christa , Nabage Melisande , Bossardi Ramon , Marinello Michael , Mena Agustina Hebe , Gilliard Kurrim , Spite Matthew , Adam Alejandro , MacNamara Katherine C. , Fredman Gabrielle 
Published: January 2023

AbstractAging is associated with non-resolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a pro-resolving ligand that acts through the G-protein coupled receptor (GPCR) called GRP18. Using an unbiased screen, we report increasedGpr18expression in macrophages from old mice and in livers from elderly humans that is associated with increased steatosis and fibrosis in middle-aged (MA) and old mice. MA mice that lack GPR18 on myeloid cells had exacerbated steatosis and hepatic fibrosis, which was associated with a decline in Mac2+ macrophages. Treatment of MA mice with RvD2 reduced steatosis and decreased hepatic fibrosis, correlating with increased Mac2+ macrophages, monocyte-derived macrophages and elevated numbers of monocytes in the liver, blood, and bone marrow. RvD2 acted directly upon the bone marrow to increase monocyte-macrophage progenitors. Using a transplantation assay we further demonstrated that bone marrow from old mice facilitated hepatic collagen accumulation in young mice, and transient RvD2 treatment to mice transplanted with bone marrow from old mice prevented hepatic collagen accumulation. Together, our study demonstrates that RvD2-GPR18 signaling controls steatosis and fibrosis and provides a mechanistic-based therapy for promoting liver repair in aging.
A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms
Authors: McSwiggen David T. , Liu Helen , Tan Ruensern , Puig Sebastia Agramunt , Akella Lakshmi B. , Berman Russell , Bretan Mason , Chen Hanzhe , Darzacq Xavier , Ford Kelsey , Godbey Ruth , Gonzalez Eric , Hanuka Adi , Heckert Alec , Ho Jaclyn J. , Johnson Stephanie L. , Kelso Reed , Klammer Aaron , Krishnamurthy Ruchira , Li Jifu , Lin Kevin , Margolin Brian , McNamara Patrick , Meyer Laurence , Pierce Sarah E. , Sule Akshay , Stashko Connor , Tang Yangzhong , Anderson Daniel J. , Beck Hilary P. 
Published: January 2023

AbstractThe regulation of cell physiology depends largely upon interactions of functionally distinct proteins and cellular components. These interactions may be transient or long-lived, but often affect protein motion. Measurement of protein dynamics within a cellular environment, particularly while perturbing protein function with small molecules, may enable dissection of key interactions and facilitate drug discovery; however, current approaches are limited by throughput with respect to data acquisition and analysis. As a result, studies using super-resolution imaging are typically drawing conclusions from tens of cells and a few experimental conditions tested. We addressed these limitations by developing a high-throughput single-molecule tracking (htSMT) platform for pharmacologic dissection of protein dynamics in living cells at an unprecedented scale (capable of imaging > 106cells/day and screening > 104compounds). We applied htSMT to measure the cellular dynamics of fluorescently tagged estrogen receptor (ER) and screened a diverse library to identify small molecules that perturbed ER function in real time. With this one experimental modality, we determined the potency, pathway selectivity, target engagement, and mechanism of action for identified hits. Kinetic htSMT experiments were capable of distinguishing between on-target and on-pathway modulators of ER signaling. Integrated pathway analysis recapitulated the network of known ER interaction partners and suggested potentially novel, kinase-mediated regulatory mechanisms. The sensitivity of htSMT revealed a new correlation between ER dynamics and the ability of ER antagonists to suppress cancer cell growth. Therefore, measuring protein motion at scale is a powerful method to investigate dynamic interactions among proteins and may facilitate the identification and characterization of novel therapeutics.
Programme responses for men who perpetrate intimate partner violence in the context of alcohol or other drugs: a scoping review
Authors: Nguyen Van , Kertesz Margaret , Davidson Jennifer , Humphreys Cathy , Laslett Anne-Marie 
Published: January 2023

Purpose
Substance use plays a significant role in the perpetration of much intimate partner violence (IPV). However, responses to these two issues are rarely integrated. Single focus programme responses can lead to poor outcomes for men as well as their families experiencing these intersecting issues. This scoping paper aims to establish the current state of knowledge on contextual factors influencing the development and implementation of combined programmes.

Design/methodology/approach
Four electronic databases were systematically searched in May 2021 and December 2021. Twenty-one peer-reviewed studies reporting on ten programmes were included.

Findings
This scoping review revealed that combined programme responses are an underdeveloped area of research and evaluation. The limited evidence base indicated systemic barriers hindering services’ capacity to expand this field of work, affecting implementation and outcomes. Support is required from the wider service systems to intervene in men’s perpetration of IPV in the context of substance use.

Practical implications
Findings in this scoping review demonstrate the importance of fostering a coordinated and collective response to IPV in the context of substance use. Combined programmes have the potential to reduce siloed practices, enabling more holistic responses for men with intersecting issues. However, researchers and policymakers must also address contextual issues hindering or enabling combined programmes’ implementation and development.

Originality/value
Mapping the evidence based on combined programmes provides direction for further development and research to expand this field of inquiry.
Climate-related financial disclosure in integrated reporting: what is the impact on the business model? The case of Poste Italiane
Authors: Galeone Graziana , Onorato Grazia , Shini Matilda , Dell’Atti Vittorio 
Published: January 2023

Purpose
Sustainable development has become a strategic priority for companies. The purpose of this study is to explain what paths a company can take to reconfigure its business model and corporate reporting tools in line with the United Nations’ Sustainable Development Goals (SDGs).

Design/methodology/approach
The research used a qualitative approach and drew on stakeholder and legitimacy theories to collect primary and secondary data through in-depth interviews, semi-structured questionnaires and observation of corporate documents.

Findings
Sustainability and climate change issues’ relevance in the business model and reporting requires improvement so that stakeholders can participate and become aware of the actions put in place to limit the climate challenge.

Research limitations/implications
The results of the case study cannot be subjected to statistical generalisation, as they focus on the Italian context and do not capture the regulatory divergence of different countries.

Practical implications
The results can help managers experiment with, orient, test and implement business model transformations to increase the level of sustainability within an organisation. In addition, disclosure of climate change risks and opportunities for the company and the resulting impacts, including financial impacts, is now recognised as a key urgency to support the achievement of the SDGs and the stakeholder decision-making process.

Originality/value
This study contributes to the literature by focusing on necessary developments for governance and strategy and on climate change disclosure to support investors’ and other stakeholders’ decision-making processes for corporate social responsibility.