bluuebunny/crossref_metadata_2025_split huggingface dataset:
Need Analysis of Workshops for Effective Teaching among teachers at Secondary School level in Karachi, Pakistan
Authors: Karim Rabia Abdul , Niazi Salma , Saeed Farida 
Published: January 2023

Nowadays, teachers’ role is considered as a vital place in the academic success of students because they have a strong impact on helping, shaping, creating, supporting and establishing student’s strengths, goals and facilitating them to explore knowledge. It is essential that the teachers should be equipped to the professional skills and competencies as well as possess required qualities and characteristics that are needed in learning process. Today, teacher has to develop their skills and broaden their approach for teaching through a wide range of creative activities and share various innovative ideas that can be incorporated in teaching to engage students in an effective manner as well as able to apply different strategies to keep students motivated during learning process. For this purpose teacher has to involve in various training sessions especially workshops as they are very helpful for that need. The main objectives of this study is to highlight the importance of workshop for teachers to enhance the abilities of classroom management & implementation for latest techniques, better understanding of students learning needs and more productivity towards effective teaching process. The method that was used in this study was descriptive method. The population of study was consisted on teachers of private schools in Karachi. Within those 100 teachers from 32 schools were selected as sample for the data collection by using questionnaire. The results revealed the essential importance of workshop at school level as a growing need of effective teaching-learning process among teachers and students. One of the major challenges of countless social and economic issues is low-quality education system. Among all the SDGs, SDG4 mainly highlights to provide high quality education. SDG4 means, striving to have every child receiving high-quality education by 2030.The major hindrance in learning skill is being taught by the teachers, who are not interested in the professional development programs. Teachers training workshops are becoming one of the important sources to cope with continuous changes occurring in teaching-learning process therefore it should be a part of educative setup from school level. In the light of results, recommendations were also presented such as training workshop should be conducted as per need of diverse aspect of teaching skills and practices, feedback is essential need to the fast changing demands of teaching learning process and to develop the mode of participation in it among teachers for advancement at their work places. The students trained and guided by the professionally equipped teachers would be in a better position to put their knowledge and abilities into greater use for economic development and growth of the country.
Effect of Contextual Inquiry Approach on Interest Towards Science and Achievement in Earth Science among Grade 10 Students
Authors: Taratara-Fadero Aizelle 
Published: January 2023

This study determined the effect of the contextual inquiry approach (CIA) on interest in science and achievement in Earth Science among grade 10 students at Ferrol National High School. In CIA, students are doing inquiry-based learning using situations and materials that are within their context and locality. The pretest–posttest control group quasi-experimental design was employed in the study, which involved two matched classes of 30 students each, both implementing the 7Es inquiry model: elicit, explore, engage, explain, elaborate, evaluate, and extend. The experimental class used the CIA in conducting the activities and providing examples about the concept while the control group used pictures in delivering 10 learning competencies in Earth Science topics. The instruments used were the 40-item researcher-made achievement test in Earth Science and 12-item Science Inventory Test modified from the Program for International Student Assessment. Results showed that the CIA helped improve students’ achievement in Earth science (ƞp2 = .11). In classes implementing the 7Es inquiry model, CIA is comparable to the conventional teaching approach (CTA) in improving students’ interest in science. However, interest in science and achievement in Earth Science are not related to each other. This advances the argument that the attitude-achievement paradox is possibly existent among Filipino learners.
Rancang Bangun Inkubator Tetas Telur Otomatis di Peternakan Unggas Dengan Metode Proportional Integral Derivative
Authors: Sugiarto  
Published: January 2023

Penelitian ini bertujuan untuk merancang dan membangun inkubator tetas telur otomatis yang mempunyai tingkat keberhasilan penetasan atau daya tetas yang tinggi. Penelitian dilaksanakan di Peternakan Ayam Marno. Penelitian ini menggunakan Metode Prototype yang meliputi desain sistem, perancangan hardware, perancangan software, pengujian hardware dan software, dan analisis pengujian. Pada sistem kontrol suhu digunakan pengontrol tegangan AC dengan kendali PID untuk mendapatkan kestabilan suhu yang tinggi. Sistem kontrol kelembapan mengunakan kontrol ON-OFF untuk mengontrol kerja kipas dan humidifier sehingga kelembapan dapat diatur sesuai yang dibutuhkan selama proses penetasan. Pemutaran telur dilakukan secara otomatis menggunakan modul RTC DS1307 yang memutar telur 180º setiap 2 jam sekali dengan penggerak motor AC. Pengecekan penetasan telur menggunakan sensor PIR sebagai pendeteksi gerakan, dan buzzer serta Modul NodeMCU ESP8266 sebagain notifikasi dan mengirimkan pesan ke telegram. Untuk mengantisipasi pemadaman listrik selama proses penetasan digunakan baterai 12V 10Ah dan perangkat inverter 500W sebagai backup sumber listrik cadangan. Sistem kontrol suhu yang dirancang menggunakan kontroler PID menggunakan Arduino dengan nilai Kp= 25, Ki= 20 dan Kd=10 yang didapat dengan metode trial and error, berosilasi kurang dari 0.2ºC dari nilai acuan yang ditetapkan 39ºC. Sistem kontrol kelembapan menggunkan kontroler ON-OFF mampu mempertahan nilai kelembapan sesuai yang dibutuhkan dalam penetasan telur ayam. Inkubator tetas telur yang dirancang di harapkan dapat menetaskan telur ayam kampung dengan baik.
Implementasi Metode Vector Space Model pada Aplikasi Makanan Sehat Untuk Penderita Penyakit Kronis
Authors: Tashid Tashid , Hidayat Wahyu 
Published: January 2023

Di Indonesia jumlah penyandang penyakit kronis, kusus nya penyakit hipertensi secara nasional pada tahun 2018 juga masih tinggi, yaitu sebesar 34,1%, tetapi yang terdiagnosis oleh tenaga kesehatan dan atau riwayat minum obat hanya sebesar 8,8%. Bila tidak dideteksi secara dini dan mendapat pengobatan yang memadai, hipertensi dapat menimbulkan kerusakan pada organ vital, antara lain: jantung, ginjal. Semakin tinggi tekanan darah, semakin tinggi pula kerusakan yang ditimbulkan hingga dapat menyebabkan gagal ginjal, penyakit jantung koroner, dan stroke. Hipertensi yang tidak terkontrol juga dapat menyebabkan kebutaan dan gagal jantung berdasarkan hasil penelitian diketahui kematian akibat komplikasi hipertensi mencapai 9,4 juta setiap tahunnya di seluruh dunia. Oleh karena itu peneliti membuat sebuah Aplikasi Menu makanan sehat untuk penderita penyakit kronis berbasis android dengan menggunakan salah satu metode dalam Text Mining yaitu Vector Space Model (VSM). Metode ini digunakan untuk mengukur kemiripan antara suatu dokumen dengan suatu query. Pada aplikasi yang akan dibuat, Pengguna yang memiliki penyakit kronis, bisa memasukan keywoard pada mesin pencarian, nantinya aplikasi akan memberikan rekomendasi makanan yang sesuai dengan keywoard yang di masukan. Dari penelitian ini diharapkan dapat menghasilkan sebuah aplikasi menu makanan sehat untuk penderita penyakit kronis berbasis android yang dapat membantu masyarakat dalam mengetahui solusi menu makanan sehat untuk penderita penyakit kronis.
Sistem Penunjang Keputusan PNS Berprestasi dan Teladan Dilingkungan Dinas Kominfo Kabupaten Tanah Datar Menggunakan Metode SAW
Authors: Firdaus Rahmad 
Published: January 2023

Sistem Penunjang Keputusan merupakan sebuah sistem yang dibuat untuk menunjang seseorang membuat keputusan yang akurat dan tepat. Menurut data yang didapat dari Dinas Komunikasi dan Informatika Kabupaten Tanah Datar saat ini pelaksanaan kegiatan PNS berprestasi dan teladan menerapkan sistem pencatatan manual yang datanya masih direkap menggunakan Microsoft excel sehingga hal tersebut masih dibilang tidak efektif dan efisien dalam pengolahan data serta pengambilan keputusan yang masih terbilang subjektif tanpa adanya data pendukung dan nilai yang pasti terhadap sebuah keputusan sehingga menimbulkan pertanyaan dan menjadi buah bibir oleh Pegawai Negeri Sipil yang lain. Untuk menyelesaikan permasalahan tersebut dibutuhkan aplikasi SPK berbasis web dengan menggunakan metode Simple Additive Weight (SAW) untuk menunjang pelaksanaan kegiatan PNS berprestasi dan teladan. Aplikasi tersebut dikembangkan dengan kerangka website HTML, dengan bahasa pemrograman PHP dan MySQL sebagai database. Hasil akhir dari penelitian ini adalah terciptanya aplikasi Sistem Penunjang Keputusan PNS berprestasi dan teladan yang dapat menunjang pelakasanaan kegiatan.
Juliano, hacedor de mártires y arquetipo de maldad
Authors: Sánchez Jaén Jesús 
Published: January 2023

Resumen
El ejemplo que podía representar la tolerancia de Juliano resultó tan peligroso que se combatió su imagen de manera expeditiva, llegando al extremo de convertirlo en la personificación del Mal. A tal fin se le atribuyeron crímenes y martirios ficticios, creando un estereotipo que perduró durante varios siglos y que ejemplificaba la aniquilación del enemigo, no solo del pagano, sino también del hereje. Juliano y sus crímenes se convirtieron en algo así como una metáfora de la derrota que Dios infringe a los rivales de la Iglesia oficial.
Radio Advertising in Italy at the Time of the Pandemic
Authors: Sergio Giuseppe 
Published: January 2023

The article focuses on a specific form of advertising – radio advertising – at a time when it was called upon to change itself, namely during the first phase of the Coronavirus pandemic. Taking into consideration a corpus of radio advertisements broadcast during the programme La Zanzara, on air on Radio24, the main rhetorical, morpho-syntactic and lexical aspects are considered. The linguistic profile that emerges is not particularly lively, nor do the adverts show that they have fully adapted to the pandemic.
Projective Embeddings of Ball Quotients, Birational to a Bi-elliptic Surface
Authors: Kasparian Azniv 
Published: January 2023

For a neat lattice $$\Gamma < SU(1,2)$$, whose quotient $${\mathbb B} / \Gamma$$ is birational to a bi-elliptic surface, we compute the dimensions of the cuspidal $$\Gamma$$-modular forms $$[ \Gamma,n]_o$$ and all modular forms $$[ \Gamma, n]$$ of weight $$n \geq 2. $$ The work provides a sufficient condition for a subspace $$V \subset [ \Gamma, n]$$ to determine a regular projective embedding of the Baily-Borel compactification $$\widehat{ {\mathbb B} / \Gamma}$$ and applies this criterion to a specific example.
Two New Modifications of the InterCriteria Analysis
Authors: Vassilev Peter , Todorova Lyudmila , Popov Elenko , Georgieva Radostina , Slavov Chavdar , Atanassov Krassimir 
Published: January 2023

In the present work two modifications of the InterCriteria Analysis are proposed in order to extend its theoretical foundation. The results obtained from the application of these methods over real data (from patients with prostate carcinoma) have been analyzed to determine the reliability of the calculated consonance and dissonance.
The similarity scores obtained by the modified versions of the InterCriteria Analysis are close to those given by the classical InterCriteria Analysis, as well as to the values of the correlation coefficients between the considered criteria. This shows the reliability of the proposed modification with respect to determining the consonance and dissonance between criteria in different problems.
Assessment of Quality of Life Among Patients With Recurrent Clostridioides difficile Infection Treated with Investigational Oral Microbiome Therapeutic SER-109
Authors: Garey Kevin W. , Jo Jinhee , Gonzales-Luna Anne J. , Lapin Brittany , Deshpande Abhishek , Wang Elaine , Hasson Brooke , Pham Sissi V. , Huang Shirley P. , Reese Pat Ray , Wu Henry , Hohmann Elizabeth , Feuerstadt Paul , Oneto Caterina , Berenson Charles S. , Lee Christine , McGovern Barbara , vonMoltke Lisa 
Published: January 2023

ImportanceRecurrent Clostridioides difficile infection (CDI) is a debilitating disease leading to poor health-related quality of life (HRQOL), loss of productivity, anxiety, and depression. The potential association of treatment with HRQOL has not been well evaluated.ObjectivesTo explore the association of SER-109 compared with placebo on HRQOL in patients with recurrent CDI up to week 8.Design, Setting, and ParticipantsThis study was a secondary analysis of a randomized, double-blind, placebo-controlled trial that took place at 56 sites in the US and Canada from July 2017 to April 2020 and included 182 patients randomized to SER-109 or placebo groups.InterventionsSER-109 or placebo (4 capsules once daily for 3 days) following antibiotics for CDI.Main Outcomes and MeasuresExploratory analysis of HRQOL using the disease specific Clostridioides difficile Quality of Life Survey (Cdiff32) assessed at baseline, week 1, and week 8.ResultsIn this study, 182 patients (109 [59.9%] female; mean age, 65.5 [16.5] years) were randomized to SER-109 (89 [48.9%]) or placebo (93 [51.1%]) groups and were included in the primary and exploratory analyses. Baseline Cdiff32 scores were similar between patients in the SER-109 and placebo groups (52.0 [18.3] vs 52.8 [18.7], respectively). The proportion of patients with overall improvement from baseline in the Cdiff32 total score was higher in the SER-109 arm than placebo at week 1 (49.4% vs 26.9%; P = .012) and week 8 (66.3% vs 48.4%; P = .001).Greater improvements in total and physical domain and subdomain scores were observed in patients in the SER-109 group compared with placebo as early as week 1, with continued improvements observed at week 8. Among patients in the placebo group, improvements in HRQOL were primarily observed in patients with nonrecurrent CDI while patients in the SER-109 group reported improvements in HRQOL, regardless of clinical outcome.Conclusions and RelevanceIn this secondary analysis of a phase 3 clinical trial, SER-109, an investigational microbiome therapeutic was associated with rapid and steady improvement in HRQOL compared with placebo through 8 weeks, an important patient-reported outcome.Trial RegistrationClinicalTrials.gov Identifier: NCT03183128
High‐Efficiency Reactive Oxygen Species Generation by Multiphase and TiO6 Distortion‐Mediated Superior Piezocatalysis in Perovskite Ferroelectrics
Authors: Huang Yanli , Lv Boyan , Zhao Chunlin , Yin Jie , Wang Yabin , Wang Yang , Fu Xinmiao , Wu Tianmin , Wu Jiagang , Zhang Xianzeng 
Published: January 2023

AbstractPiezocatalysis, governed by piezo‐potential within piezoelectrics, has gained prominence for reactive oxygen species (ROS) generation, which is significant to environmental and biological applications. However, designing piezocatalysts with excellent piezocatalytic performance in a wide temperature and efficient charge carrier separation ability is still challenging. Herein, eco‐friendly BaTiO3 (BT)‐based perovskite ferroelectrics with tailored multiphase coexistence in a wide temperature range are constructed to boost higher piezoelectricity and large piezo‐potential, which is attributed to decreased polarization anisotropy by flat Gibbs energy profile. Elevated piezo‐potential in designed BT‐based piezocatalyst guarantees high‐efficient generation rate of •OH (200 µmol g−1 h−1) and •O2− (40 µmol g−1 h−1) by ultrasound stimulation, which is 3.5 times more than that of pure BT. Besides, piezocatalytic capacity to degrade dye wastewater shows a rate constant of 0.0182 min−1 and gives an antibacterial rate of 95% within 30 min for eliminating E. coli. Theoretical simulations validate that the local distortion of TiO6 octahedra also contributes to piezocatalytic performance by inducing electron–hole pairs separation in real space, and better response to slight structural deformation. This work is important to design high‐performance piezocatalysts with high‐efficiency ROS generation for sewage treatment and sonodynamic therapy.
Screening of Zwitterionic Liposomes with Red Blood Cell‐Hitchhiking and Tumor Cell‐Active Transporting Capability for Efficient Tumor Entrance
Authors: Zhao Zhihao , Feng Yupu , Xiang Jiajia , Liu Jing , Piao Ying , Shao Shiqun , Tang Jianbin , Zhou Zhuxian , Shen Youqing 
Published: January 2023

AbstractThe active transport of nanoparticles into the solid tumor through cell transcytosis has shown great promise in cancer nanomedicine, but it is challenging to develop efficient active transporting nanomedicines with the potential for clinical translation. Here, a type of tertiary amine oxide (TAO)‐containing zwitterionic liposomal nanocarriers is developed that can hitchhike red blood cells (RBCs) to tumor blood vessels and enter solid tumors through transcytosis. To boost the active‐transporting capability, a library of the TAO liposomes (TAOLs) with different chemical structures and particle sizes is constructed and screened by their stability and active transporting capability. Two types of TAOLs are identified that can induce efficient tumor cell transcytosis through rapid macropinocytosis and endoplasmic reticulum/Golgi‐involved exocytosis. It is found that these zwitterionic TAOLs can hitchhike RBCs to gain long blood circulation, get off the cell at the tumor site, effectively enter the tumor through transcytosis, and infiltrate the whole tumor. The chemotherapeutic drug‐loaded liposomes can stop the tumor progression of mice bearing human hepatocellular carcinoma HepG2 cells, exhibiting superior antitumor activity compared to the traditional liposomal drug. This study demonstrates a strategy to construct effective active transporting liposomal nanomedicines for efficient tumor entrance.
Novel Ionizable Lipid Nanoparticles for SARS‐CoV‐2 Omicron mRNA Delivery
Authors: Long Jinrong , Yu Changxiao , Zhang Honglei , Cao Yiming , Sang Ye , Lu Haitao , Zhang Zhen , Wang Xin , Wang Huanyu , Song Gengshen , Yang Jing , Wang Shengqi 
Published: January 2023

AbstractmRNA‐based therapy has emerged as the most promising nucleic acid therapy in the fight against COVID‐19. However, a safe and efficacious systemic delivery remains a challenge for mRNA therapy. Lipid nanoparticles (LNPs) are currently widely used in mRNA delivery vehicles. Here, a series of ionizable LNPs is rationally designed. YK009‐LNP is an optimal delivery platform to carry mRNA. YK009‐LNP exhibits higher mRNA delivery efficiency, a more favorable biodistribution pattern, and better safety than the approved MC3‐LNP. In addition, mRNA encoding severe acute respiratory syndrome coronavirus 2 Omicron receptor binding domain protein is synthesized and intramuscular administration of mice with YK009‐LNP‐Omicron mRNA induces a robust immune response and immune protective effect. A novel mRNA delivery vehicle with more powerful delivery efficiency and better safety than the approved LNPs is provided here.
Flexible Zinc–Air Batteries with Ampere‐Hour Capacities and Wide‐Temperature Adaptabilities
Authors: Zhong Xiongwei , Zheng Zhiyang , Xu Jiahe , Xiao Xiao , Sun Chongbo , Zhang Mengtian , Ma Jiabin , Xu Baomin , Yu Kuang , Zhang Xuan , Cheng Hui‐Ming , Zhou Guangmin 
Published: January 2023

AbstractFlexible Zn–air batteries (FZABs) have significant potentials as efficient energy storage devices for wearable electronics because of their safeties and high energy‐to‐cost ratios. However, their application is limited by their short cycle lives, low discharge capacities per cycle, and high charge/discharge polarizations. Accordingly, herein, a poly(sodium acrylate)–polyvinyl alcohol (PANa–PVA)–ionic liquid (IL) hydrogel (PANa–PVA–IL) is prepared using a hygroscopic IL, 1‐ethyl‐3‐methylimidazolium chloride, as an additive for twin‐chain PANa–PVA. PANa–PVA–IL exhibits a high conductivity of 306.9 mS cm−1 and a water uptake of 2515 wt% at room temperature. Moreover, a low‐cost bifunctional catalyst, namely, Co9S8 nanoparticles anchored on N‐ and S‐co‐doped activated carbon black pearls 2000 (Co9S8‐NSABP), is synthesized, which demonstrates a low O2 reversibility potential gap of 0.629 V. FZABs based on PANa–PVA–IL and Co9S8‐NSABP demonstrate high discharge capacities of 1.67 mAh cm−2 per cycle and long cycle lives of 330 h. Large‐scale flexible rechargeable Zn–air pouch cells exhibit total capacities of 1.03 Ah and energy densities of 246 Wh kgcell−1. This study provides new information about hydrogels with high ionic conductivities and water uptakes and should facilitate the application of FZABs in wearable electronics.
Computer‐Aided Design and Analysis of Spectrally Aligned Hybrid Plasmonic Nanojunctions for SERS Detection of Nucleobases
Authors: Davison Gemma , Jones Tabitha , Liu Jia , Kim Juhwan , Yin Yidan , Kim Doeun , Chio Weng‐I Katherine , Parkin Ivan P. , Jeong Hyeon‐Ho , Lee Tung‐Chun 
Published: January 2023

AbstractHybrid plasmonic nanojunctions with optimal surface‐enhanced Raman scattering (SERS) activity are designed via a computer‐aided approach, and fabricated via time‐controlled aqueous self‐assembly of core@shell gold@silver nanoparticles (Au@Ag NPs) with cucurbit[7]uril (CB7) upon simple mixing. The authors showed that SERS signals can be significantly boosted by the incorporation of a strong plasmonic metal and the spectral alignment between the maximal localized surface plasmon resonance (LSPR) and a laser wavelength used for SERS excitation. In a proof‐of‐concept application, SERS detection of nucleobases with a 633‐nm laser has been demonstrated by positioning them within the nanojunctions via formation of host–guest complexes with CB7, achieving rapid response with a detection limit down to sub‐nanomolar concentration and an enhancement factor (EF) up to ≈109–1010, i.e., the minimum required EF for single‐molecule detection. Furthermore, machine‐learning‐driven multiplexing of nucleobases is demonstrated, which shows promise in point‐of‐care diagnosis of diseases related to oxidative damage of DNA and wastewater‐based epidemiology.
SERS Detection of Breast Cancer‐Derived Exosomes Using a Nanostructured Pt‐Black Template
Authors: Li Xinyue , Keshavarz Meysam , Kassanos Panagiotis , Kidy Zahra , Roddan Alfie , Yeatman Eric , Thompson Alex J. 
Published: January 2023

AbstractAt present, there are no cancer treatments that are both non‐invasive and highly accurate. New tests that can diagnose cancer at an early stage would help to facilitate such improved therapies, and many recent studies have focused on the development of liquid biopsy tests for this purpose. Exosomes are extracellular vesicles secreted by cells as a means of communication that can be simply collected from blood samples. Current studies have shown the potential of surface‐enhanced Raman spectroscopy (SERS) in differentiating cancerous cells from healthy cells. Herein, a bespoke platinum‐black (Pt‐black) SERS template is developed—via a cost‐effective fabrication method of electroplating—to detect malfunctioned (cancerous) exosomes. The results demonstrate that the Pt‐black SERS substrate exhibits stable and consistent spectra, which produces the high reproducibility required for a reliable diagnostic template. More importantly, using the Pt‐black SERS template allows for the differentiation of cancer‐derived exosomes (extracted from 4T1 cells—a triple‐negative breast cancer cell line) and exosomes from healthy fibroblast cells with an 83.3% sensitivity and a 95.8% specificity. This study establishes the potential of the Pt‐black template in detecting cancerous exosomes and lays a solid foundation for future studies in the clinical application of SERS in cancer diagnosis.