bluuebunny/crossref_metadata_2025_split huggingface dataset:
Level of Awareness, Adoption and Constraints of Jasmine Growers
Authors: Anand G. , Jaisridhar P. , Janakirani A. , Karthikeyan C. , Sheeba S. Mercy 
Published: September 2023

The Tiruchirappalli (Trichy) and Dindigul districts of Tamil Nadu state were purposively taken for studying objectives viz., profile, awareness, adoption and constraints faced by the jasmine growers. The sampling technique was multi-stage purposive sampling and the research design adopted was descriptive method. A total sample size of 160 (jasmine growers). The secondary data was collected through structured interview schedule. The frequency and percentage were worked-out to quantify the secondary data. PRA preference ranking/problem ranking matrix methodology was used to rank the production and marketing led constraints based on the perceived level of severity by the jasmine growers. Likewise to study the determinants of awareness and adoption with that of the profile, the correction and regression co-efficient was used. It was evident that, there was cent percent awareness and adoption of variety, planting season. Though there was cent percent awareness on pruning technique, only 88.13 % adopted the practice. Very least awareness level (7.50 % & 14.38 %) was observed with respect to post harvest management practice like enhancing shelf-life and off-season flowering technology respectively. The proportion of non-adopter were high with respect to bio-fertilizer application (78.13 %), use of bio-stimulant (81.88 %), off-season flowering spraying (90.63 %) and enhancement of shelf-life through boric acid (100 %). Majority (71.88 %) of farmers were having only medium level of awareness, similarly little more than half (58.75 %) of the farmers had only medium level of adoption. The score obtained through problem matrix ranking revealed that, labour shortage during peak flowering season with highest mean score of 35.50 was ranked as foremost constraint in production and Price fluctuation /market risk with highest mean score of 37.50 was perceived as the foremost constraint in marketing of jasmine.
Influence of Organic Manure and Inorganic Fertilizers on Growth and Yield of Radish (Raphanus sativus L.) in Gird Region of Madhya Pradesh, India
Authors: Kumar Sumit , Kumar Pushpendra , Jatav Vinod , Dukpa Pinkey , Suman Shekhar 
Published: September 2023

A field experiment was conducted to study the effect of organic manure and inorganic fertilizers on growth and yield of Radish (Raphanus sativus L.) in Grid region of Madhya Pradesh as factorial based on the randomized block design(RBD) with three replication and Ten treatments viz., T1-(100% NPK through inorganic sources), T2-(100% NPK through Farm Yard manure (16t/ha)), T3-(100% NPK through Vermicompost (12t/ha)), T4-(100% NPK through Poultry Manure (9.48t/ha)), T5-(75% NPK+25%N through FYM), T6-(75% NPK+25% N through Vermicompost), T7-(75% NPK+25% N through Poultry manure), T8-(50% NPK+50% N through FYM), T9-(50% NPK+50% N through Vermicompost), T10-(50% NPK+50% N through Poultry manure) were made up of singlevariety Ivory white the experiment was planted in the CRC-II, School of agriculture, ITM University Gwalior. At all of the periodic crop growth phases except at 15 DAS, T6 showed significant plant height and leaf count increases across crop phases. T5, T6 had maximum heights; T3, T10 had minimum. T5, T6, T8 displayed the highest leaf counts; T1 the least. Leaf lengths followed a similar trend, with T8, T6 having the longest; T1 the shortest. Overall, T6 exhibited prominent growth in both height and leaf attributes, while T1 consistently showed the lowest values throughout all stages and measurements. The conventional practices T6 had significant positive influence on yield and yield attributing parameters, viz; root length (35.05cm), weight of whole plant (418.91g), initial fresh weight of roots (355.54g) but initial fresh weight of leaves (72.52g) in recorded in treatment T2, root diameter (50.61mm), girth of root (12.3cm), dry weight of leaves (13.49g) measured in T2, dry weight of root (102.19g), root yield per plot (21.33kg), root yield per hectare (319.98qha-1). Conclusion-: Economically the application of 75% NPK+25% N through vermicompost gave maximum net return (Rs. 262553.80) and BC ratio (3.94).
Determination of Virulence Genes in Extended Spectrum Beta Lactamase-Producing Escherichia coli Isolated from Fresh Leafy Vegetables Sold in Rivers State, Nigeria
Authors: Achinike Okwelle, Austin , Osakuade, Felicia O.  
Published: September 2023

Extended-spectrum β-lactamases (ESBL’S) are a rapidly growing group of β-lactamases which have the ability to hydrolyze third generation antibiotics such as Cephalosporins and Aztreonam. The aim of this study is the determination of virulence genes in ESBL- producing Escherichia. coli isolated from cabbage, spinach and water leaf. but are inhibited by Clavulanic Acid. The randomised experimental design was used to collect cabbage (Brassica oleracea), water leaf (Hydrophyllum macrophyllum) and spinach (Spinacia oleracea) samples from retailer sellers in two different markets (Choba and Rumuosi daily markets) of Obio/Akpor Local Government Area, Rivers State. Water leaf samples had a mean count of 2.9×103, spinach sample mean count was 2.8×104 Cfu/g and the highest, while the lowest mean count was obtained from cabbage samples; 1.6×103 Cfu/g. The study has established the presence of pathogenic E. coli (Enterohaemorrhagic) which are Shiga toxin producers that are Highly virulent with low infections doses.
Applicability of the 1470 Nm Diode Laser in Facial Aesthetics: An Evidence-Based Review
Authors: Furtado Gisele Rosada Donola , Barbosa Kledson Lopes , Costa Michelle Fechine , Lustosa Diogo Belas , Castilho Vivian Almeida , Tardin Claudia Dazzi dos Reis , Paulino Ana Carolina Pereira , Valenca Joao Luiz Batista , Gomes Flavianny Silva Artiaga Andrade 
Published: September 2023

Introduction: Endolaser or Endolift® is a minimally invasive procedure carried out using a diode laser with a wavelength that can range from 980 to 1470 nm. This laser is inserted into the subcutaneous layer through an optical fibre probe to reduce fat and induce skin retraction via neocollagenesis.
Objectives: To assess the effects of the 1470 nm diode laser on subdermal lipolysis and rejuvenation based on evidence-based practice.
Methodology: An evidence-based literature review was conducted to elucidate the impact of the 1470 nm diode laser on facial rejuvenation. This review involved an exploration of scientific articles published and accessible within the databases MEDLINE, PubMed, SCIELO, and LILACS, spanning the years from 2013 to 2023.
Results: Six reports utilising the 1470 nm diode laser for aesthetic purposes were identified, underscoring the prevailing knowledge gap regarding applying the 1470 nm diode laser for aesthetic purposes such as lipolysis and as an adjunct for facial rejuvenation.
Conclusion: While the 1470 nm diode laser is currently widespread within the domain of facial aesthetics, a constrained body of research with a high level of scientific evidence exists. This suggests an urgent requirement for well-designed further investigations, such as randomised clinical trials.
Are there metacognitive benefits of learner‐ and instructor‐generated visualizations?
Authors: Fiorella Logan , Jaeger Allison J. 
Published: September 2023

AbstractThis study explored how different formats of instructional visuals affect the accuracy of students' metacognitive judgments. Undergraduates (n = 133) studied a series of five biology texts and made judgments of learning. Students were assigned randomly to study the texts only (text only), study the texts with provided visuals (provided visuals group), study the texts and generate their own visuals (learner‐generated visuals group), or study the texts and observe animations of instructor‐generated visuals (instructor‐generated visuals group). After studying the texts and making judgments of learning, all students completed multiple‐choice comprehension tests on each text. The learner‐generated and instructor‐generated visuals groups exhibited significantly higher relative judgment accuracy than the text only and provided visuals groups, though this effect was relatively small. The learner‐generated visuals group also required more study time and was more likely to report the use of visual cues when making their judgments of learning.
Multifunctional Mesoporous Polydopamine‐Based Systematic Delivery of STING Agonist for Enhanced Synergistic Photothermal‐Immunotherapy
Authors: Zeng Wenfeng , Li Zimu , Huang Qili , Ding Chendi , Yang Li , Wang Wenyan , Shi Zhaoqing , Yang Yao , Chen Hongzhong , Mei Lin , Zeng Xiaowei 
Published: September 2023

AbstractThe therapeutic application of STING agonists in various malignancies has been limited by factors such as the inability of systemic administration and the immunosuppressive tumor microenvironment. Herein, this work reports a mesoporous polydopamine‐based multifunctional nanoplatform loaded with STING agonist MSA‐2 and chelated with Mn2+ for synergistic photothermal and STING activation‐based immunotherapy. The nanoplatform effectively delivers MSA‐2 to the tumor site and intelligently releases its contents through acid degradation, facilitated by the photothermal effect. Additionally, the thermal ablation of tumor tissue can induce immunogenic cell death, which helps alleviate the immunosuppressive tumor microenvironment, thereby enhancing the efficacy of MSA‐2. Furthermore, Mn2+ works as a dual‐acting STING sensitizer and MRI contrast agent which not only boosts the immune response but also allows real‐time MRI tracking of the nanoplatform. This strategy is proved highly efficacious both in impeding primary/metastatic tumor and in eliciting a robust tumor‐specific immune response. Collectively, an effective multifunctional nanoplatform for the systemic delivery of STING agonist which synergized photothermal therapy and STING pathway activation‐mediated immunotherapy is highlighted here to provide new ideas and strategies for optimizing combination therapy for cancer treatment.
Engineering Near‐Infrared Plasmonic Spiky Gold Nanostructures for Highly Efficient Surface‐Enhanced Raman Spectroscopy‐Guided Cancer Hyperthermia Therapy
Authors: Jiang Renting , Li Jianqin , Li Linhu , Lu Yaxuan , Zhang Huiming , Li Ming 
Published: September 2023

AbstractCancer phototheranostics utilizing plasmonic materials is attracting considerable interest due to its high spatiotemporal precision and specificity, remote controllability, superior therapeutic efficacy, and low systemic side effects. Exploring new plasmonic materials with excellent plasmonic and photothermal properties is at the frontier of cancer phototheranostics. Herein, this work systematically investigates the plasmonic and photothermal properties of spiky Au nanoparticles (NPs) with different shaped central cores – spiky Au nanosphere , spiky Au nanocube and spiky Au nanorod (AuNR). It is shown that the shape of the central core in spiky Au NPs has significant effects on their surface‐enhanced Raman spectroscopy (SERS) and photothermal performances, and spiky Au NPs of a spherical or cubic core are much superior for near‐infrared (NIR) SERS detection and hyperthermia therapy in comparison with spiky AuNRs. The spiky Au NP‐based SERS probes demonstrate the remarkable capability for SERS imaging of live cells and dynamic visualization of tumors in a 4T1 breast tumor mouse model after intravenous administration. Moreover, in vivo studies show exceptional hyperthermia therapeutic effects of such SERS probes against 4T1 breast tumors under NIR irradiation. This study suggests the potential utility of spiky Au NP‐based SERS probes for efficient SERS‐guided cancer hyperthermia therapy.
A Tumoricidal Lipoprotein Complex Electrostatically Stabilized on Mesoporous Silica as Nanotherapeutics and Nanoadjuvant for Potentiating Immunotherapy of Triple Negative Breast Cancer
Authors: Pei Wei , Li Yuqing , Wu Yixian , Wu Yuan , Cai Ling , Wang Shaozhuo , Wang Shoulin , Chen Jin 
Published: September 2023

AbstractAs the most aggressive subtype, triple‐negative breast cancer (TNBC) without definitive targets represents a high probability of metastasis. Nevertheless, the presence of high‐level tumor‐infiltrating lymphocytes in the TNBC tumor microenvironment (TME) suggests patients may benefit from immunotherapy. In this study, bovine α‐lactalbumin coupled with oleic acid that forms tumoricidal lipid–protein complex (BAMLET) is electrostatically stabilized on the surface of amino‐functionalized mesoporous silica nanoparticles (MSN‐NH2). It is found that MSN‐NH2 may cause partial conformational changes of immobilized proteins due to electrostatic interactions. Therefore, BAMLET covered MSN‐NH2 (BMSN) as a drug cargo that can not only induce selectively oncolytic effect but kill tumor cells with rapid kinetics. Moreover, the hemolytic activity of BMSN conjugated with pre‐formed serum protein corona is largely reduced which may avoid the poor hemocompatibility caused by BAMLET. Furthermore, the in vivo study indicates that the combinational use of drug‐loaded BMSN and immune checkpoint small‐molecule inhibitor can efficiently inhibit the growth of solid TNBC tumors and activate immune response by sufficient infiltration of immune cells in the TME and prevent the seeding of circulating tumor cells. Therefore, the constructed BMSN provides an integrated nanotherapeutics and a nanoadjuvant with superior anticancer performance to combat TNBC.
Bend‐Resistant and Energy‐Friendly GO‐PVA/PVA Polymer Electret Synaptic Transistors for Neuromorphic Computations
Authors: Fu Xiao , Liang Zhihao , Shuai Wentao , Li Yushan , Ning Honglong , Su Guoping , Lu Xubing , Xie Weiguang , Yao Rihui , Peng Junbiao 
Published: September 2023

AbstractPolymer electret synaptic transistor is a promising three‐terminal artificial synaptic device. In this work, the electrical characteristics of the composite insulator and transistor are enhanced by modulating the concentration of the 2D nanofiller graphene oxide (GO) and the stacked film structure based on a polyvinyl alcohol (PVA) matrix. The GO‐PVA/PVA polymer electret synaptic transistors before and after dynamic/static bending exhibit typical synaptic characteristics, including short‐term plasticity, long‐term plasticity, pair‐pulse facilitation, spike‐timing‐dependent plasticity, and “learning–forgetting–relearning” features. Importantly, the device exhibits good cycling stability, uniformity and linearity in the potentiation‐depression cycling test, which is beneficial for improving the accuracy of neuromorphic computations. Also, it shows extremely low energy consumption (≈0.32 fJ). The recognition accuracy of images is simulated based on the constructed artificial neural network, which achieves 86.8% for the MNIST dataset. In addition, the devices maintain high recognition accuracy after dynamic/static bending, indicating that the devices are extremely bend‐resistant. The GO‐PVA/PVA polymer electret synaptic transistor is expected to be a potential candidate for neuromorphic computations and electronic skin.
DNA Origami: From Molecular Folding Art to Drug Delivery Technology
Authors: Jiang Qiao , Shang Yingxu , Xie Yiming , Ding Baoquan 
Published: September 2023

AbstractDNA molecules that store genetic information in living creatures can be repurposed as building blocks to construct artificial architectures, ranging from the nanoscale to the microscale. The precise fabrication of self‐assembled DNA nanomaterials and their various applications have greatly impacted nanoscience and nanotechnology. More specifically, the DNA origami technique has realized the assembly of various nanostructures featuring rationally predesigned geometries, precise addressability, and versatile programmability, as well as remarkable biocompatibility. These features have elevated DNA origami from academic interest to an emerging class of drug delivery platform for a wide range of diseases. In this minireview, the latest advances in the burgeoning field of DNA‐origami‐based innovative platforms for regulating biological functions and delivering versatile drugs are presented. Challenges regarding the novel drug vehicle's safety, stability, targeting strategy, and future clinical translation are also discussed.
Tumor Microenvironment‐Responsive Nanoparticles Amplifying STING Signaling Pathway for Cancer Immunotherapy
Authors: Liu Dan , Liang Shuang , Ma Kongshuo , Meng Qian‐Fang , Li Xingang , Wei Jian , Zhou Mengli , Yun Kaiqing , Pan Yuanwei , Rao Lang , Chen Xiaoyuan , Wang Zhaohui 
Published: September 2023

AbstractInsufficient activation of the stimulator of interferon genes (STING) signaling pathway and profoundly immunosuppressive microenvironment largely limits the effect of cancer immunotherapy. Herein, tumor microenvironment (TME)‐responsive nanoparticles (PMM NPs) are exploited that simultaneously harness STING and Toll‐like receptor 4 (TLR4) to augment STING activation via TLR4‐mediated nuclear factor‐kappa B signaling pathway stimulation, leading to the increased secretion of type I interferons (i.e., 4.0‐fold enhancement of IFN‐β) and pro‐inflammatory cytokines to promote a specific T cell immune response. Moreover, PMM NPs relieve the immunosuppression of the TME by decreasing the percentage of regulatory T cells, and polarizing M2 macrophages to the M1 type, thus creating an immune‐supportive TME to unleash a cascade adaptive immune response. Combined with an anti‐PD‐1 antibody, synergistic efficacy is achieved in both inflamed colorectal cancer and noninflamed metastatic breast tumor models. Moreover, rechallenging tumor‐free animals with homotypic cells induced complete tumor rejection, indicating the generation of systemic antitumor memory. These TME‐responsive nanoparticles may open a new avenue to achieve the spatiotemporal orchestration of STING activation, providing a promising clinical candidate for next‐generation cancer immunotherapy.
Efficient CO2 Electroreduction to Multicarbon Products at CuSiO3/CuO Derived Interfaces in Ordered Pores
Authors: Li Qun , Wu Jiabin , Lv Lei , Zheng Lirong , Zheng Qiang , Li Siyang , Yang Caoyu , Long Chang , Chen Sheng , Tang Zhiyong 
Published: September 2023

AbstractElectrochemical CO2 conversion to value‐added multicarbon (C2+) chemicals holds promise for reducing CO2 emissions and advancing carbon neutrality. However, achieving both high conversion rate and selectivity remains challenging due to the limited active sites on catalysts for carbon–carbon (C─C) coupling. Herein, porous CuO is coated with amorphous CuSiO3 (p‐CuSiO3/CuO) to maximize the active interface sites, enabling efficient CO2 reduction to C2+ products. Significantly, the p‐CuSiO3/CuO catalyst exhibits impressive C2+ Faradaic efficiency (FE) of 77.8% in an H‐cell at −1.2 V versus reversible hydrogen electrode in 0.1 M KHCO3 and remarkable C2H4 and C2+ FEs of 82% and 91.7% in a flow cell at a current density of 400 mA cm−2 in 1 M KOH. In situ characterizations and theoretical calculations reveal that the active interfaces facilitate CO2 activation and lower the formation energy of the key intermediate *OCCOH, thus promoting CO2 conversion to C2+. This work provides a rational design for steering the active sites toward C2+ products.
Access to 2‐Sulfonyl‐4‐arylphenols and 2,6‐Bis‐sulfonyl 5‐Aryl‐4‐arylidene‐2‐cyclohexenones via Metal Triflates‐Catalyzed Domino Cyclocondensation of 1,3‐Bis‐sulfonylacetones and 3‐Arylacroleins
Authors: Chang Meng‐Yang , Hsueh Nai‐Chen 
Published: September 2023

AbstractHerein, metal triflates–catalyzed one‐pot domino cyclocondensation of 1,3‐bis‐sulfonylacetones and 3‐arylacroleins via (3+3) or (3+2+1) annulation has been proposed to construct diversified 2‐sulfonyl‐4‐arylphenols and 2,6‐bis‐sulfonyl 5‐aryl‐4‐arylidene‐2‐cyclohexenones. In this effective reaction, C−C and C=C bonds are formed via a cascade process and 3‐arylacrolein acts as a C3 and C1 synthon during the formation of a six‐membered ring system under mild conditions. A plausible mechanism has been proposed and discussed.
VOC of Inverted Perovskite Solar Cells Based on N‐Doped PCBM Exceeds 1.2 V: Interface Energy Alignment and Synergistic Passivation
Authors: Sun Xiuhong , Li Yonghai , Liu Dachang , Liu Ruichen , Zhang Bingqian , Tian Qingyong , Fan Bin , Wang Xianzhao , Li Zhipeng , Shao Zhipeng , Wang Xiao , Cui Guanglei , Pang Shuping 
Published: September 2023

AbstractPhenyl‐C61‐butyric acid methyl ester (PCBM) remains the most commonly used electron transport layer in inverted perovskite solar cells (IPSCs). However, its insufficient electrical properties and passivation ability limit the device's performance. In this study, it is demonstrated that introducing an appropriate amount of n‐type polymer N2200 into the PCBM can simultaneously enhance the electrical properties of PCBM and passivate the defects distributed on perovskite surface. This modification of PCBM leads to improved band alignment and enhanced electron mobility. Simultaneously, N2200 polymer contains electron donors such as O, S involved in passivating uncoordinated Pb2+ defects. The PCBM@N2200‐based IPSCs exhibit an enhanced open‐circuit voltage (VOC) of 1.20 V with the minimum 0.36 V voltage loss and reach the champion power conversion efficiency (PCE) of 24.53% (certified PCE is 24.05%) with narrow distribution. Impressively, the corresponding module achieves an efficiency of 20.30% (11.19 cm2). Moreover, the PCBM@N2200‐based IPSCs maintain 96% of their initial efficiency after operating at the maximum power point for 500 h, thanks to the interfacial passivation, improved uniformity, and increased hydrophobicity resulting from N2200 doping.
Effects of exercise on whole‐blood transcriptome profile in children with overweight/obesity
Authors: Altmäe Signe , Plaza‐Florido Abel , Esteban Francisco J. , Anguita‐Ruiz Augusto , Krjutškov Kaarel , Katayama Shintaro , Einarsdottir Elisabet , Kere Juha , Radom‐Aizik Shlomit , Ortega Francisco B. 
Published: September 2023

AbstractBackgroundThe current knowledge about the molecular mechanisms underlying the health benefits of exercise is still limited, especially in childhood. We set out to investigate the effects of a 20‐week exercise intervention on whole‐blood transcriptome profile (RNA‐seq) in children with overweight/obesity.MethodsTwenty‐four children (10.21 ± 1.33 years, 46% girls) with overweight/obesity, were randomized to either a 20‐week exercise program (intervention group; n = 10), or to a no‐exercise control group (n = 14). Whole‐blood transcriptome profile was analyzed using RNA‐seq by STRT technique with GlobinLock technology.ResultsFollowing the 20‐week exercise intervention program, 161 genes were differentially expressed between the exercise and the control groups among boys, and 121 genes among girls (p‐value <0.05), while after multiple correction, no significant difference between exercise and control groups persisted in gene expression profiles (FDR >0.05). Genes enriched in GO processes and molecular pathways showed different immune response in boys (antigen processing and presentation, infections, and T cell receptor complex) and in girls (Fc epsilon RI signaling pathway) (FDR <0.05).ConclusionThese results suggest that 20‐week exercise intervention program alters the molecular pathways involved in immune processes in children with overweight/obesity.