bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulatory influence of exercise training against Cisplatin inveigled inflammatory markers and dyslipidemia in rats
Authors: Parastesh Mohammad , Aria Behzad , Abbasi Yusef , Yousefvand Zahra 
Published: February 2023

Abstract
Background and objective: Cisplatin treats some cancers, but its side effects have questioned its use. It seems that exercise activity can reduce its side effects. The present study aimed to investigate the impact of two types of exercise training on some inflammatory markers and dyslipidemia induced by Cisplatin in rats.
Methods: 24 Sprague Dawley rats were divided into four groups: Healthy control (HC), Cisplatin control (CC), Cisplatin moderate-intensity continuous training (C-MICT), and Cisplatin high-intensity interval training (C-HIIT). Intraperitoneal injection induced irradiation at a 5‏mg/kg dose dissolved in normal saline. The exercise training lasted ten weeks.
Results: Cisplatin significantly increased Interleukin-6 (IL-6; p<0.05) and tumor necrosis factor-alpha (TNF-α; p<0.05) in the cisplatin control group. However, there was no difference between IL-6 in the HC, C-MICT, and C-HIIT groups. The TNF-α in the two training groups was higher than the healthy control group (p<0.05) but lower than the Cisplatin control group (p<0.05). Also, the two training groups observed no significant difference between serum levels of IL-6 and TNF-α (p>0.05). Total cholesterol (TC), Triglycerides (TG), and Low-density lipoprotein cholesterol (LDL-C) were significantly higher in CC than in other groups (p<0.05) but High-density lipoprotein cholesterol (HDL-C) was lower(p<0.05). Both types of exercise training caused a significant decrease in LDL, TC, and TG(p<0.05), and a significant increase in HDL-C (p>0.05). Finally, there was no difference between the two types of exercise training on lipoproteins(p>0.05).
Conclusion: It seems that MICT and HIIT can reduce inflammatory responses and improve blood lipids profile in rats induced by Cisplatin.
Evolutionary Algorithm for Optimized CNN Architecture Search Applied to Real-Time Boat Detection in Aerial Images
Authors: Zerrouk Ilham , Moumen Younes , Khiati Wassim , Habchi Ali El , Berrich Jamal , Bouchentouf Toumi 
Published: February 2023

Abstract
When processing the detection of boats on aerial images by neural networks, we have always been concerned about the execution time of these networks in the equipment on board the Unmanned AerialVehicle (UAV). The UAV, throughout its mission, will capture images that must be processed in realtime. For this, an execution time optimized network is essential. This article proposes a method for searching for optimized detection networks, for a given dataset, using an evolutionary algorithm. The search uses mutations as a mechanism of evolution that affect the structure of the network and the hyper-parameters of its layers. Its fitness function allows the choice of architectures that are not very greedy in terms of operations favoring small networks whose advantages are to be fast and quick to train and thus to accelerate the search algorithm. Thanks to this method we were able to obtain detection networks with performance similar to the initial network (parent) but with much fewer operations allowing considerable gains in terms of execution times in an environment embedded on a drone.
The role of structural distortions in triggering the metal to insulator transition in NdNiO3
Authors: Gomes Mariana , Balagopalan Manjunath , Vilarinho Rui , Bassou Abderrazzak Ait , Silva Bruna , Oliveira João , Almeida Bernardo , Almeida Abílio , Kreisel Jens , Tavares Pedro , Íñiguez Jorge , Moreira Joaquim 
Published: February 2023

Abstract
The role of the structural distortions on the metal to insulator transition (MIT) of NdNiO3 is still a controversial topic. NdNiO3 ceramic, 260 nm and 110 nm thin films deposited onto (001)-oriented LaAlO3 substrates were studied to unravel the effect of structural symmetry breaking on the electronic phase transition. Resistivity measurements evidence the coexistence of metallic and insulating states below the TMI, while magnetization measurements confirm the expected TMI = TN for all samples. The structural symmetry was investigated across the MIT, through Raman scattering spectroscopy, with the orthorhombic Pnma phase being found at high temperatures, but the emergence of the monoclinic P21/n phase only occurring well below TMI, which is an unexpected experimental result since the structural transition has been understood as a necessary trigger for the MIT. These experimental results, which are noticeably independent of the sample type/quality, imply a temperature difference between the structural and electronic/magnetic ordering, thus contrasting with current theoretical models.
Analyses of natural okra extracts as corrosion inhibitors on mild steel in acidic medium
Authors: Sulaimon Aliyu Adebayo , Murungi Pearl Isabellah , Tackie-Otoo Bennet Nii , Nwankwo Princess Christiana , Bustam Mohamad Azmi 
Published: February 2023

Abstract
Plant extracts have been shown to effectively inhibit the corrosion of metals. Using the Box-Behnken, gravimetric, and electrochemical techniques, analyses were designed to investigate the anti-corrosion potential of okra in a 1M HCl medium. The inhibition performances derived from the various methods were in good agreement, demonstrating that physio-chemisorption was effective and adhered to the Langmuir isotherm. The efficiency of okra mucilage powder was 96% at a much lower concentration, compared to 91.2% and 88.4% for the unsieved extract and gelly-okra filtrate, respectively. FTIR results showed the presence of several functional groups that promoted adsorption, and TGA analysis revealed that the extract had high thermal stability. The FESEM analysis also revealed evidence of adsorption. It was determined that corrosion inhibition by okra mucilage extract was primarily influenced by temperature, followed by extract concentration, with immersion time having the least effect. From the model optimization goal, 200ppm, 60°C, and 24h for 89.98% IE gave a high desirability. The results showed the high capacity of okra as an efficient biodegradable corrosion inhibitor.
Mediterranean Diet and Associations with the Gut Microbiota and Pediatric-Onset Multiple Sclerosis: a Trivariate Analysis
Authors: Mirza Ali , Zhu Feng , Knox Natalie , Black Lucinda , Daly Alison , Bonner Christine , Domselaar Gary Van , Bernstein Charles , Marrie Ruth Ann , Hart Janace , Yeh Eluen Ann , Bar-Or Amit , O’Mahony Julia , Zhao Yinshan , Hsiao William , Banwell Brenda , Waubant Emmanuelle , Tremlett Helen 
Published: February 2023

Abstract

The interplay between diet and the gut microbiota in multiple sclerosis (MS) is poorly understood. We conducted a case-control study to assess an interrelationship between diet, the gut microbiota, and MS by including 95 participants (44 pediatric-onset MS cases, 51 unaffected controls) enrolled from the Canadian Pediatric Demyelinating Disease Network study. All had completed a food-frequency questionnaire ≤ 21-years of age, and 59 also provided a stool sample. A 1-point increase in a Mediterranean diet score was associated with 37% reduced MS odds (95%CI: 10–53%). Higher fiber and iron intakes were also associated with reduced MS odds. Diet, not MS, explained inter-individual gut microbiota variation. Several gut microbes abundances were associated with both the Mediterranean diet score and MS presence, and these microbes were potential mediators of the protective associations of a healthier diet. Findings suggest that the potential interaction between diet and the gut microbiota is relevant in MS.
Perceived stigma of COVID-19 patients in Shanghai, China, in the third year of the pandemic: A cross-sectional social impact survey
Authors: Deng Ziru , Bernot Ausma , Davies Sara E. 
Published: February 2023

Abstract
Introduction
Social stigma associated with Covid-19 infection has been reported around the world. This paper investigates the level of self-reported perceived stigma among people infected with COVID-19 in Shanghai, China, in the third year of the pandemic to determine changes in perceived stigma and individual level variables associated with perceived stigma.
Methods
We conducted a self-reported two-part online survey (n = 144 responses) by employing a convenience sampling method of COVID-19 patients in Shanghai. The first part of the survey collects sociodemographic information of the respondents and the second part outlines 24 items of the Social Impact Scale (SIS), which measures social rejection, financial insecurity, internalized shame, social isolation. We ran Wilcoxon signed-ranks test, Kruskal-Wallis test, and linear regression analysis to assess the levels of perceived stigma differences.
Results
The study finds that the overall level of self-reported stigma during the COVID-19 lockdowns in Shanghai in 2022 was moderate, and lower than that compared to the self-reported perceived stigma study in Wuhan in 2020. In Shanghai, the severity of the disease and hospitalization times had most impact on financial insecurity and feelings of social isolation. These experiences were not gendered. Recovery measures, including economic considerations, need to pay particular attention to those who experienced severe disease.
Dual inhibition of thioredoxin 1/ glutathione induces ferroptosis in chronic myeloid leukemia cells
Authors: Cao Peng , Sun Xiaoyan , Zhang Chunli , Fan Bo , Liu Qingyu , Wang Shuxia , Chen Ting , Cai Xueting , Wang Xiaoqing , Hu Chunping , Sun Han-Dong , Wen Zhongpei , Puno Pematenzin 
Published: February 2023

Abstract
Ferroptosis is an iron-dependent cell death induced by the oxidation of polyunsaturated fatty acids. In recent years, ferroptosis has garnered tremendous potential in cancer therapy. However, the significance pathways of ferroptosis in chronic myeloid leukemia (CML) therapy are still poorly understood. Here, we investigated the role of a critical antioxidant protein, thioredoxin 1 (Trx1), in regulating ferroptosis in CML cells. First, we showed that Trx1 expression was higher in patients with CML than in healthy controls. Specifically, Trx1 knockdown suppressed cell growth and slowed tumor progression in xenograft models. Pharmacological inhibitors of Trx1 also attenuated cell growth, reduced colony formation, and caused CML cell death. Second, we showed that decreased Trx1 expression enhanced the cytotoxicity of the glutathione (GSH) biosynthesis inhibitor buthionine sulfoximine. Mechanistically, the combined inhibition of Trx1 and GSH synthesis disrupted the homeostasis of cellular reactive oxygen species as evidenced by increased ROS and malondialdehyde; and decreased GSH. Importantly, inhibition of Trx1 significantly resentisized GSH-depletion induced ferroptosis in CML cells. Finally, targeting Trx1 and GSH synthesis with small-molecule inhibitors caused a synergic effect on CML cells both in vitro and in vivo.Together, these results highlight an critical role of Trx1 in GSH-depletion induced ferroptosis and provide clues for dual inhibition of the Trx1 and GSH system as a combinatorial strategy for CML therapy.
Cellular Schwannoma of the Kidney: a case report and review of the literature
Authors: Liu Jiong , An Xiaojing , Yang Bin , Zhang Wei , Dong Xiaoxia 
Published: February 2023

Abstract
Background: Cellular schwannomas (CS) are uncommon tumors derived the schwan cell of peripheral nerve,which are rare in the kidneys, and only individual cases have been reported. Because there are no typical clinical symptoms and imaging features, CS is usually misdiagnosed as synovial sarcoma or malignant peripheral nerve sheath tumor (MPNST) resulting in overtreatment.
Case presentation: A 68-year-old woman presented to hospital without clinical symptoms, who was incidentally found to have an renal-occupying lesion during physical examination. Abdominal computed tomography and magnetic resonance imaging revealed a solid lesion in the middle of the left kidney. The lesion was 5.7 × 3.6cm2.
Conclusions: CS was diagnosed depend on the combination of pathomorphology, immunohistochemistry and molecular. The patient underwwent surgery. Follow-up data were available and no recurrence or metastasis found.
Neural encoding with unsupervised spiking convolutional neural network
Authors: Wang Chong , Yan Hongmei , Huang Wei , Sheng Wei , Wang Yuting , Fan Yun-Shuang , Liu Tao , Zou Ting , Li Rong , Chen Huafu 
Published: February 2023

Abstract
Accurately predicting the brain responses to various stimuli is big challenge in neuroscience. Although recent fMRI studies have made significant breakthroughs in neural encoding using convolutional neural networks (CNNs), there remains critical gaps between the computational rules of traditional artificial neurons and real biological neurons. Here, we present a spiking CNN (SCNN)-based framework to accomplish neural encoding in a more biologically plausible way. The framework extracts visual features of the image stimuli using the unsupervised SCNN and predicts fMRI responses from the SCNN features using a receptive field-based regression algorithm. Experimental results on both handwritten characters and natural images demonstrate that our approach can achieve surprisingly good encoding performance and be used for realizing “brain reading” tasks such as image reconstruction and image identification. Our work suggests that SNN can serve as a promising tool for neural encoding.
Investigating genetic overlap between antidepressant and lithium response and treatment resistance in major depressive disorder
Authors: Lu Yi , Xiong Ying , Karlsson Robert , Song Jie , Kowalec Kaarina , Rück Christian , Sigstrom Robert , Jonsson Lina , Clements Caitlin , Andersson Evelyn , Boberg Julia , Lewis Cathryn , Sullivan Patrick , Landén Mikael 
Published: February 2023

Abstract
Treatment response and resistance in major depressive disorder (MDD) are suggested to be heritable. Due to significant challenges in defining treatment-related phenotypes, our understanding of their genetic bases is limited. This study aimed to derive a stringent definition of treatment resistance and to investigate genetic overlap between treatment response and resistance in MDD. Using electronic medical records on the use of antidepressants and electroconvulsive therapy (ECT) from Swedish registers, we derived the phenotype of treatment-resistant depression (TRD) within ~ 4 500 individuals with MDD in three Swedish cohorts. Considering antidepressants and lithium are first-line treatment and augmentation used for MDD, respectively, we generated polygenic risk scores of antidepressant and lithium response for individuals with MDD, and evaluated their associations with treatment resistance by comparing TRD with non-TRD. Among 1 778 ECT-treated MDD cases, nearly all (94%) used antidepressants before first ECT, and the vast majority had at least one (84%) or two (61%) antidepressants of adequate duration, suggesting these MDD cases receiving ECT were resistant to antidepressants. We found that TRD cases tend to have lower genetic load of antidepressant response than non-TRD, although the difference was not significant; furthermore, TRD cases had significantly higher genetic load of lithium response (OR = 1.10–1.12 under different definitions). The results support evidence of heritable components in treatment-related phenotypes and highlight the overall genetic profile of lithium-sensitivity in TRD. This finding further provides a genetic explanation for lithium efficacy in treating TRD.
Using Free Online Readings to Teach Introduction to American Government
Authors: Kaufman Chelsea 
Published: February 2023

Abstract
Several studies have examined using electronic textbooks as compared to print textbooks, or open educational resources (OER) compared to commercial textbooks. Fewer studies, however, examine the use of free or low-cost online readings that are not an OER textbook or assigned in conjunction with a textbook. In my introductory American Government course, all assigned course readings were items that students could access for free online or through the university library. The use of these free or low-cost materials should have provided similar benefits to students as the adoption of an OER textbook typically would, namely cost savings. At the same time, they could have drawbacks similar to OERs and electronic textbooks, such as students having difficulty finding information within the text or accessing materials if they do not have home Internet access. Furthermore, this approach required more preparatory work for the instructor. Based on a survey of my students in the course, I found that students had positive evaluations of the course materials and recommended that they be used in future courses. As expected, their overall assessments were similar to those of electronic textbooks and OERs.
Food Insecurity and Dental Caries in Rural Mexican Populations
Authors: Romo-Sáenz César Iván , Chavez-Reyes Erika Marlene , Gomez-Flores Ricardo , González-Flores María Norma , Sosa-Martínez Ricardo , Cruz-Fierro Norma , Elizondo-Elizondo Jose , Garza-Ramos Myriam Angelica 
Published: February 2023

Abstract
Objectives
Food insecurity (FI) is a priority for government and health organizations. Over 95% of the world's population has a carious lesion or will develop one before death. This study evaluated the association between FI and oral health in two rural communities in Chiapas, Mexico.
Materials and methods
The study was conducted with patients attending an oral health campaign for dental check-ups. Data were collected between April and August of 2017 using the Latin-American and Caribbean Scale of Food Security (ELCSA) and the International Caries Detection and Assessment System (ICDAS). We included 209 participants from the communities of Siltepec and Huehuetan, Mexico; 67% were women.
Results
The results of the ELCSA were mild FI in 43% (n = 91), moderate FI in 22% (n = 45), and severe FI (n = 6) in 3%; 32% had food security. The ICDAS results were initial decay with a mean of 6.22, moderate decay with a mean of 1.81, and extensive decay with a mean of 1.77.
Conclusions
In this study, the FI level was lower than in other rural populations in Mexico. The level of dental caries found was expected for this population.
Clinical Relevance
Food insecurity is associated with dental caries. Food insecure individuals have a higher probability of severe dental caries. Identifying these individuals and addressing the factors related to food insecurity can be useful in rural communities.
Hold It Close: Male Octopus Hold Their Hectocotylus Closer to Their Body
Authors: Weertman Willem , Scheel David 
Published: February 2023

Abstract
The right third arm of the male octopus is the hectocotylized arm. This arm is modified by anatomy specialized to hold and transfer sperm packets to the female, and lacks suckers at the distal end. Male octopus may be distinguished by the skilled eye from their habit of holding their hectocotylus closer to their body in a protective manner, although this observation has never been described quantitatively. We utilized a three-step process of data annotation, pose estimation model training, and model inference to show that this common observation is true of Octopus rubescens. In 2338 images, the eyes, mantle tip, and arm tips of 2 male (n = 1152) and 3 female (n = 1085) octopuses were annotated by an experimenter. These images were then used to train a DeepLabCut pose estimation model which achieved a RMSE of 1.78 cm. This model was then used to annotate 11.4 hours (n = 408985 images) of 4 female and 8 male octopuses moving across the middle of a large aquarium. We then compared the human annotated data, and the model inference data separately. In both datasets we compared the arm tip to eye centered point distances, as well as the octopus centric arm tip 90% kernel density estimation area. In both the training dataset and the model inference datasets we found a common result. Male O. rubescens hold their third to the right arm closer to their body than all seven other arms while the females do not.
Fabrication of a Uniform Chromate Conversion Coating on Zn Alloy for Improved Corrosion Resistance in Humid Environments
Authors: Ha Seonghye , Eun Jakyung , Choi Changhoon , Cho Soohyoun , Jeon Sangmin 
Published: February 2023

Abstract
We developed a facile method to produce a uniform chromate conversion (CC) coating on zinc alloy-plated steel substrates (ZS). When an acidic CC solution is applied to ZS (C-ZS), zinc is dissolved and chromium ions are reduced to form a chromate coating. In localized areas where zinc is excessively dissolved, zinc hydroxide particles are formed, which hinders the formation of a uniform chromate film, leaving the areas vulnerable to further corrosion (i.e., the formation of dark spots) when exposed to high humidity conditions. To suppress the excessive dissolution of zinc, the ZS surface was pretreated with thiolated polyethylene oxide to form a hydrophilic self-assembled monolayer. A more uniform protective CC coating was obtained on the pretreated ZS, resulting in superior corrosion resistance under high humidity conditions.
Organic Dots-PVA as a Platform for Wound Dressing
Authors: Afkhami Hamed , Oskouie Iman Menbari , Mohammadi Leili , Dezfuli Amin Shiralizadeh 
Published: February 2023

Abstract
We utilize a new nanocomposite material to give a report about a new platform for wound dressing. It is worth mentioning synergistic mixing graphene quantum dots (as a type of organic dots (ODs)) and polyvinyl alcohol (PVA) are materials participating in fabrication of the nanocomposite mentioned. We brought staphylococcus aureus as a gram-positive bacterium and pseudomonas aeruginosa as a gram-negative bacterium into play to optimize their antibacterial activity. We evaluated Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for OD/PVA nanocomposite. Our optimizations resulted as a persistent level against methicillin-resistant staphylococcus aureus (MRSA) in higher ratios of OD. Vitro studies and MTT assay were used for determination the optimum ratio of OD to PVA. We quantified burned wound infection models and the colony forming units CFUs in the burn wound which were in vivo studies by a standard colony counting method. Finally, the results show the mechanism of antibacterial activity of nanocomposite described as a contact mediated oxidative stress induction.