bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of preoperative venous thromboembolism on patients undergoing TURBT: Perioperative outcomes and healthcare costs from US insurance claims data
Authors: Tresh Anas S. , Del Giudice Francesco , Li Shufeng , Basran Satvir , De Berardinis Ettore , Carino Dalila , Santarelli Valerio , Rocco Bernardo , Shighinolfi Maria Chiara , Mayr Roman , Ferro Matteo , Autorino Riccardo , Bignante Gabriele , Crocetto Felice , Barone Biagio , Pichler Renate , Subiela José Daniel , Velasco Jorge Caño , Moschini Marco , Mari Andrea , Gallioli Andrea , Soria Francesco , Albisinni Simone , Krajewski Wojciech , Łaszkiewicz Jan , Nowak Łukasz , Szydełko Tomasz , Challacombe Benjamin , Nair Rajesh , Chung Benjamin I. 
Published: January 2025

AbstractObjectivesTo assess the impact of a positive history of venous thromboembolism (VTE) on perioperative outcomes, including length of in‐hospital stay, readmission rates, 90‐day postoperative complications, and healthcare costs in bladder cancer (BCa) patients undergoing transurethral resection of bladder tumour (TURBT) in the United States.Patients and MethodsPatients aged ≥18 years with a BCa diagnosis undergoing TURBT were identified in the Merative® Marketscan® Research de‐identified databases between 2007 and 2021. Multivariable logistic regression adjusted by relevant perioperative confounders was used to investigate the association between diagnosis of VTE before TURBT and 90‐day complication rates, new postoperative VTE events, re‐hospitalization, and total hospital expenditures (2021 US dollars). Sensitivity analyses on VTE severity (pulmonary embolism [PE], deep venous thrombosis [DVT] or superficial thrombophlebitis/phlebitis [SVT]), as well as TURBT extent (minor vs. major) were additionally examined.ResultsIn total, 139 800 patients were identified, with 5.3% having preoperative VTE, including DVT (n = 3112, 42.20%), PE (n = 2046, 27.74%) and SVT (n = 2217, 30.06%). A history of preoperative VTE predicted higher rates of any complication (adjusted odds ratio [aOR] 1.28, 95% CI 1.14–1.43) and also higher rates of infectious and haemorrhagic complications. Additionally, preoperative VTE increased the risk of novel VTE events following TURBT (aOR 17.30, 95% CI 16.05–18.65), hospital length of stay (aOR 2.23, 95% CI 1.90–2.62), readmissions (aOR 1.47, 95% CI 1.39–1.56), and hospital associated costs (aOR 1.17, 95% CI 1.12–1.23). DVT and non‐minor TURBT procedures did not increase the risk of any, infectious, or haemorrhagic complications, but other associations were maintained regardless of the severity of VTE (PE, DVT, SVT) or TURBT extent (minor/major).ConclusionsA history of VTE before undergoing transurethral procedures for BCa is associated with significantly worse perioperative outcomes and higher healthcare costs. These findings may help us to counsel on the risks of the intervention and hopefully improve our ability to mitigate such risks.
Multiple Contrast Tests in the Presence of Partial Heteroskedasticity
Authors: Hasler Mario , Birr Tim , Hothorn Ludwig A. 
Published: January 2025

ABSTRACTThis paper proposes a general approach for handling multiple contrast tests for normally distributed data in the presence of partial heteroskedasticity. In contrast to the usual case of complete heteroskedasticity, the treatments belong to subgroups according to their variances. Treatments within these subgroups are homoskedastic, whereas treatments of different subgroups are heteroskedastic. New candidate as well as already existing approaches are described and compared by ‐simulations. Power simulations show that a gain in power is achieved when the partial heteroskedasticity is taken into account compared to procedures which wrongly assume complete heteroskedasticity. The new approaches will be applied to a phytopathological experiment.
Post‐COVID Hypertension With Hyperreninemic Hyperaldosteronism in a Pediatric Patient
Authors: Shi Vivian , Trinka Teresa , Faizan Mohammed 
Published: January 2025

ABSTRACTCOVID‐19 infection may predispose patients to long‐term renovascular complications. Early recognition and management are crucial for optimal outcomes. This case report underscores the importance of thorough follow‐up care for children recovering from COVID‐19, with a focus on monitoring blood pressure and renal function to mitigate long‐term renovascular disease.
Tolane‐Based Phosphino‐ and Arsino‐Ruthenium Complexes in Three Different Oxidation States: Ru(I), Ru(II) and Ru(III)
Authors: Rudin Benjamin , Stein Carolin A. M. , Ballmann Joachim 
Published: January 2025

AbstractTargeting Ru(III) and Ru(I) η2‐alkyne species, 2,2’‐(iPr2E)2‐substituted diphenylacetylenes (1‐E, E=P, As) were employed for the preparation of [ECCE]‐coordinated ruthenium complexes. The reactions between 1‐E and cis‐(MeCN)2(COD)RuCl2 led to the required Ru(II) starting materials cis‐[ECCE]RuCl2(MeCN) (3‐E). Upon oxidation of 3‐E with PhICl2, the Ru(III) target complexes [ECCE]RuCl3 (7‐E) were detectable for E=P and E=As, but only the arsa‐derivative 7‐As was obtained in a pure form, namely via oxidation of cis‐[AsCCAs]RuCl2(THT) (THT=tetrahydrothiophene). Upon reduction of compounds 3‐E, a hitherto unprecedented Ru(I) η2‐alkyne complex, [PCCP]RuCl (9), was obtained for E=P. The former square planar Ru(I) complex (9) was characterized comprehensively and examined in detail by means of DFT and CASSCF calculation. Upon treatment of 9 with TlPF6, a diamagnetic μ‐Tl‐bridged compound (10) with a nearly linear Ru−Tl−Ru array was formed and isolated in high yields. Careful analysis of the bonding situation suggested that the Ru−Tl−Ru moiety in 10 is best interpreted in terms of a 3c–4e− bond.
Conformational Engineering of Flexible Protein Fragments on the Surface of Different Nanoparticles: The Surface‐Atom Mobility Rules
Authors: Zhao Wenxian , Sun Yiwei , Che Laiyu , Wang Haifang , Cao Aoneng 
Published: January 2025

AbstractAs a newly emerging technology, conformational engineering (CE) has been gradually displaying the power of producing protein‐like nanoparticles (NPs) by tuning flexible protein fragments into their original native conformation on NPs. But apparently, not all types of NPs can serve as scaffolds for CE. To expedite the CE technology on a broader variety of NPs, the essential characteristic of NPs as scaffolds for CE needs to be identified. Herein, we investigate the potential of two distinct types of NPs as scaffolds for CE: CdSe/ZnS quantum dots (QDs), an ionic compound NP, and palladium NPs (PdNPs), a metal NP. The results demonstrate that while QDs cannot support the restoration of the native conformation and function of the complementary‐determining region (CDR) fragments of antibodies, PdNPs can. The notably disparate outcomes unequivocally show that the mobility of the surface atoms/adatoms of the NPs or the mobility of the conjugating bonds to the NPs is essential for CE, which allows the conjugated peptides to undergo a conformational change from their initial random conformation to their most stable native conformation under the constraints mimicking the native long‐range interactions in the original proteins. This discovery opens the door for CE on more NPs in the future.
The physical education curriculum in alternative provision schools in England: A Gramscian critique
Authors: Maher Anthony J. , Quarmby Thomas , Hooper Oliver , Wells Victoria , Slavin Lucy 
Published: January 2025

AbstractCurriculum is at the heart of education. It has been said that a broad and balanced physical education curriculum can contribute to young people developing socially, cognitively, affectively, and physically. As such, in this article, we draw on Antonio Gramsci's ideas of culture, power, and ideology to explore the physical education curriculum in alternative provision schools in England. We did this by generating qualitative data using semi‐structured interviews with 13 physical education practitioners working in 13 different alternative provision schools. Interviews were audio recorded, and audio recordings were transcribed verbatim, before being subjected to reflexive thematic analysis. The themes generated through these analytical processes were (1) Physical education curriculum should be tailored to the needs and preferences of pupils; (2) The National Curriculum, national qualifications, assessment arrangements and Ofsted inspection expectations influence curriculum decisions; and (3) Group sizes influence the physical education curriculum. We end this article by encouraging physical education and/or curriculum scholars to learn more about alternative provision settings because, at present, there is a dearth of research‐informed knowledge about them despite them becoming a much more prominent feature of the education landscape in England.
Role of balloon dilation test in identifying suitable candidates for gastric peroral endoscopic myotomy
Authors: Gantuya Boldbaatar , Inoue Haruhiro , Yamamoto Kazuki , Iwasaki Miyuki , Ushikubo Kei , Nishikawa Yohei , Tanaka Hidenori , Tanaka Ippei , Tanabe Mayo , Abiko Satoshi , Shimamura Yuto 
Published: January 2025

AbstractBackgroundPredicting successful outcomes of gastric peroral endoscopic myotomy (G‐POEM) is essential for identifying patients who are most likely to benefit from the procedure. This study aimed to evaluate the utility of the balloon dilation test (BDT) in optimizing patient selection for G‐POEM.MethodsA retrospective study was conducted from February 2021 to December 2023, including patients with refractory gastroparesis unresponsive to conventional medical treatments. All patients completed the Gastroparesis Cardinal Symptom Index (GCSI) questionnaire before and after G‐POEM. The pyloric ring balloon dilation test was performed prior to G‐POEM, with only patients who showed a positive response included. Procedural and clinical outcomes were analyzed.ResultsFive patients (three female and two male) with refractory gastroparesis were included. The median G‐POEM procedure time was 60 minutes (interquartile range [IQR] 32.5–110), and technical success was achieved in all cases. At a median follow‐up of 10 months (IQR 6–34), clinical response was observed in all patients (100%). The GCSI score improved significantly from a median of 17 (IQR 8–33) to 0 (IQR 0–4.5; p < 0.03) indicating significant improvement in clinical symptoms.ConclusionA positive response to the balloon dilation test appears to be a reliable predictor of successful short‐term outcomes following G‐POEM in patients with refractory gastroparesis.
Mechanistic Studies of Second Coordination Sphere Interactions in the Dioxygen Activation of a Copper(I) Complex with a N‐(2‐Ethoxyethanol)‐bis(2‐picolyl)amine Ligand
Authors: Granichny Alexander , Scholl Anna Leah , Würtele Christian , Schindler Siegfried 
Published: January 2025

AbstractWhile first coordination sphere interactions have been investigated in great detail for the reactivity of copper(I) model complexes with dioxygen, the interactions of the secondary coordination sphere with the bound dioxygen so far remain underexplored. A series of copper(I) complexes with ligands based on N‐(2‐ethoxyethanol)‐bis(2‐picolyl)amine (L(O)OH) were synthesized, and the reactivity towards dioxygen was monitored by low‐temperature stopped‐flow UV/vis spectroscopy. Various “oxygen adduct complexes” were observed, and the influence of the second coordination sphere interactions was analyzed. If the ether moiety or the hydroxy group in L(O)OH is removed/replaced, the formation of a trans‐μ‐1,2‐peroxido dicopper(II) complex or a bis(μ‐oxido) dicopper(III) complex is observed. Establishing stronger hydrogen bonding while maintaining the ether moiety leads to hydrogen bond stabilized trans‐μ‐1,2‐peroxido dicopper(II) complexes. Based on these results, we deduced that the copper(I) complex with L(O)OH as ligand reacts with dioxygen first to a hydrogen bond stabilized trans‐μ‐1,2‐peroxido dicopper(II) complex, which rapidly converts to a bis(μ‐oxido) dicopper(III) complex.
Prevalence and Zoonotic Risk of Multidrug‐Resistant Escherichia coli in Bovine Subclinical Mastitis Milk: Insights Into the Virulence and Antimicrobial Resistance
Authors: Chowdhury Tonmoy , Roy Mithu Chandra , Hossain Ferdaus Mohd Altaf 
Published: January 2025

ABSTRACTThe emergence of antibiotic‐resistant microorganisms has made antimicrobial resistance a global issue, and milk is a potential source for the propagation of resistant bacteria causing zoonotic diseases. Subclinical mastitis (SCM) cases, often overlooked and mixed with normal milk in dairy farms, frequently involve E. coli, which can spread through contaminated milk. We conducted this study to determine the prevalence of virulence genes, antibiotic resistance genes (ARGs), antimicrobial susceptibility, and the genetic relatedness of multidrug‐resistant (MDR) Shiga toxin‐producing E. coli (STEC) isolated from SCM milk. SCM‐positive bovine milk was subjected to E. coli detection using cultural, biochemical, and molecular methods. Further, we detected STEC virulence genes including stx1, stx2, and eaeA. STEC isolates were tested for ARGs including blaSHV, CITM, tetA, and aac(3)‐IV, and underwent antimicrobial susceptibility tests. Moreover, we performed a phylogenetic analysis of the stx1 gene of MDR‐STEC. SCM was detected in 47.2% of milk samples of which 50.54% were E. coli positive. About 17.20% of E. coli isolates contained STEC virulence genes, and stx2 was the most prevalent. Moreover, all STEC isolates harbored at least one of the ARGs, while about 43.75% of the isolates carried multiple ARGs. Additionally, all the STEC isolates showed multidrug resistance, and were found to be fully resistant against amoxicillin, followed by ampicillin (87.50%) and gentamycin (75%); and were mostly sensitive to aztreonam (81.25%) and meropenem (68.75%). In phylogeny analysis, the stx1 gene of isolated MDR‐STEC showed close relatedness with disease‐causing non‐O157 and O157 strains of different sources including cattle, humans, and food.
SMARCA4 Deficiency in Lung Cancer: From Signaling Pathway to Potential Therapeutic Targets
Authors: Zhang Mingzhu , Dong Youhong , Meng Rui , Zhang Dongdong 
Published: January 2025

ABSTRACTSMARCA4‐deficient lung cancer, including thoracic SMARCA4‐deficient undifferentiated tumors and SMARCA4‐deficient nonsmall‐cell lung carcinomas, is a rare and aggressive disease characterized by rapid progression and poor prognosis. This cancer was identified as a distinct entity with specific morphologic and molecular features in the 2021 WHO Classification of Thoracic Tumors. Molecular alterations in SMARCA4 are specific to this type of lung cancer. Deficiency in SMARCA4 suppresses the SWI/SNF tumor suppressor complex, driving tumor progression. Due to the lack of standardized treatment, most patients succumb to the disease within 6 months. This study provides a detailed analysis of the SMARCA4 pathway and its role in lung cancer. We analyzed potential therapeutic targets and agents to offer insights for the precise and effective treatment of SMARCA4‐deficient lung cancer.
Identifying Disease Associated Multi‐Omics Network With Mixed Graphical Models Based on Markov Random Field Model
Authors: Park Jaehyun , Won Sungho 
Published: January 2025

ABSTRACTIn this article, we proposed a new method named fused mixed graphical model (FMGM), which can infer network structures associated with dichotomous phenotypes. FMGM is based on a pairwise Markov random field model, and statistical analyses including the proposed method were conducted to find biological markers and underlying network structures of the atopic dermatitis (AD) from multiomics data of 6‐month‐old infants. The performance of FMGM was evaluated with simulations by using synthetic datasets of power‐law networks, showing that FMGM had superior performance for identifying the differences of the networks compared to the separate inference with the previous method, causalMGM (F1‐scores 0.550 vs. 0.730). Furthermore, FMGM was applied to identify multiomics profiles associated with AD, and significance association was found for the correlation between carotenoid biosynthesis and RNA degradation, suggesting the importance of metabolism related to oxidative stress and microbial RNA balance. R codes can be accessed as an R package “fusedMGM,” and an example data set and a script for analyses can be found at http://figshare.com/articles/dataset/FMGM_synthetic_data_example_zip/20509113.
Transferability of Single‐ and Cross‐Tissue Transcriptome Imputation Models Across Ancestry Groups
Authors: Pagnuco Inti , Eyre Stephen , Rattray Magnus , Morris Andrew P. 
Published: January 2025

ABSTRACTTranscriptome‐wide association studies (TWAS) investigate the links between genetically regulated gene expression and complex traits. TWAS involves imputing gene expression using expression quantitative trait loci (eQTL) as predictors and testing the association between the imputed expression and the trait. The effectiveness of TWAS depends on the accuracy of these imputation models, which require genotype and gene expression data from the same samples. However, publicly accessible resources, such as the Genotype Tissue Expression (GTEx) Project, are biased toward individuals of European ancestry, potentially reducing prediction accuracy into other ancestry groups. This study explored eQTL transferability across ancestry groups by comparing two imputation models: PrediXcan (tissue‐specific) and UTMOST (cross‐tissue). Both models were trained on tissues from the GTEx Project using European ancestry individuals and then tested on data sets of European ancestry and African American individuals. Results showed that both models performed best when the training and testing data sets were from the same ancestry group, with the cross‐tissue approach generally outperforming the tissue‐specific approach. This study underscores that eQTL detection is influenced by ancestry and tissue context. Developing ancestry‐specific reference panels across tissues can improve prediction accuracy, enhancing TWAS analysis and our understanding of the biological processes contributing to complex traits.
Striving for Unity in a Culturally Fragmented World: Nested Multiple Cultural Identifications Associated With Well‐Being Through Self‐Concept Clarity
Authors: Ozer Simon , Schwartz Seth J. 
Published: January 2025

ABSTRACTIn contemporary globalised societies, global awareness and identification, as well as local and regional identifications (other than national identity), may all become increasingly important for guiding people's sense of belonging and purpose and in turn their self‐concept. As the world has become increasingly interconnected, people increasingly identify with various cultures and worldviews within both local and global contexts. Attempts to reconcile these multiple cultural identities can lead to a sense of cultural dissonance as people struggle to integrate these identities into a coherent sense of self. Accordingly, various levels/types of cultural identifications must be integrated to establish an adaptable and coherent sense of self. In two studies among participants from the United States (N = 754), we investigate how nested cultural identification at the state, national and global levels are associated with well‐being indirectly through self‐concept clarity and multiple cultural configurations. Results indicate that national identification is positively, and compartmentalisation negatively, associated with self‐concept clarity and in turn with well‐being. State and global cultural identifications were linked to multicultural identity integration and, indirectly, to components of well‐being. Results are discussed regarding the globalised proliferation of cultural identifications and the associated challenge of maintaining a stable and coherent sense of self.
Electrically Active Biomaterials for Stimulation and Regeneration in Tissue Engineering
Authors: Park Jinyoung , Akbaba Gulsah Erel , Sharma Nidhi , Das Ritopa , Vinikoor Tra , Liu Yang , Le Duong Quang , Angadi Kishan , Nguyen Thanh Duc 
Published: January 2025

ABSTRACTIn the human body, bioelectric cues are crucial for tissue stimulation and regeneration. Electrical stimulation (ES) significantly enhances the regeneration of nerves, bones, cardiovascular tissues, and wounds. However, the use of conventional devices with stimulating metal electrodes is invasive and requires external batteries. Consequently, electrically active materials with excellent biocompatibility have attracted attention for their applications in stimulation and regeneration in tissue engineering. To fully exploit the potential of these materials, biocompatibility, operating mechanisms, electrical properties, and even biodegradability should be carefully considered. In this review, we categorize various electrically active biomaterials based on their mechanisms for generating electrical cues, such as piezoelectric effect, triboelectric effect, and others. We also summarize the key material properties, including electrical characteristics and biodegradability, and describe their applications in tissue stimulation and regeneration for nerves, musculoskeletal tissues, and cardiovascular tissues. The electrically active biomaterials hold great potential for advancing the field of tissue engineering and their demonstrated success underscores the importance of continued research in this field.
Successful Use of a Midline Catheter for Leukapheresis in Patients Undergoing Collection for Immune Effector Cell Therapy, Donor Lymphocyte Infusion, and Hematopoietic Progenitor Cell Collection
Authors: Bansal Rajat , Wiedel Anthony , Hastings Riley , Boutz Fred , Abdelhakim Haitham , Ahmed Nausheen , Mushtaq Muhammad Umair , McGuirk Joseph , Abhyankar Sunil 
Published: January 2025

ABSTRACTApheresis is essential to conducting hematopoietic cell transplantation and genetically engineered cellular therapy procedures. Many patients and donors require central venous catheter (CVC) access for apheresis due to lack of adequate peripheral venous access. CVC placement has risks of associated complications and requires additional institutional resources and expertise. We present a single institutional experience with 78 patients, who underwent a total of 87 apheresis procedures after placement of a midline catheter. This included 49 individuals who collected cells for immune effector cell therapy. Apheresis through midline catheter was successful in 81 out of 87 procedures. There were no midline catheter associated thromboses or infections. Six patients required placement of a backup CVC and were able to undergo apheresis without delay. Our experience shows that use of midline catheter for apheresis is feasible and generalizable to most populations requiring cellular therapy, with the potential to decrease utilization of limited healthcare resources.