bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAP-targeted PET imaging in gastrointestinal malignancies: a comprehensive review
Authors: Arçay Öztürk Ayça , Flamen Patrick 
Published: August 2023

AbstractF18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) plays a crucial role in tumour diagnosis, staging, and therapy response evaluation of various cancer types and has been a standard imaging modality used in clinical oncology practice for many years. However, it has certain limitations in evaluating some particular gastrointestinal cancer types due to low FDG-avidity or interphering physiological background activity. Fibroblast activation protein (FAP), a protein of the tumour microenvironment, is overexpressed in a wide range of cancers which makes it an attractive target for both tumour imaging and therapy. Recently, FAP-targeted radiopharmaceuticals are widely used in clinical research and achieved great results in tumour imaging. Considering the limitations of FDG PET/CT and the lack of physiological FAP-targeted tracer uptake in liver and intestinal loops, gastrointestinal cancers are among the most promising indications of FAP-targeted imaging. Herein, we present a comprehensive review of FAP-targeted imaging in gastrointestinal cancers in order to clarify the current and potential future role of this class of molecules in gastrointestinal oncology.
The nature of the Pacific plate as subduction inputs to the northeastern Japan arc and its implication for subduction zone processes
Authors: Fujie Gou , Kodaira Shuichi , Obana Koichiro , Yamamoto Yojiro , Isse Takehi , Yamada Tomoaki , No Tetsuo , Nakamura Yasuyuki , Miura Seiichi 
Published: August 2023

AbstractDevastating megathrust earthquakes and slow earthquakes both occur along subducting plate interfaces. These interplate seismic activities are strongly dependent on the nature of the plate interface, such as the shape of the plate interface and the materials and physical conditions along the plate interface. The oceanic plate, which is the input to the subduction zone, is the first order control on the nature of the plate interface. To reveal the nature of the subduction inputs to the northeastern Japan arc, we have conducted large-scale controlled-source seismic surveys of the northwestern part of the oceanic Pacific plate. The obtained seismic data have revealed (1) oceanic plate structural evolution caused by plate bending prior to subduction, suggesting the promotion of the oceanic plate hydration; (2) spatial variation of the oceanic plate structure, such as variations in the thickness of sediment and crust; (3) that the spatial variations are caused by both ancient plate formation processes and more recent volcanic activities; and (4) that spatial variations of the nature of the subduction inputs show good correlation with the along-strike variations in the seismic structure and seismic activities after subduction, including the coseismic slip distribution of the 2011 Tohoku earthquakes and the structural differences between the northern and the southern Japan Trench. These observations indicate that the incoming oceanic plate structure is much more spatially variable than previously thought and also imply that the spatial variation of the subduction inputs is a key controlling factor of the spatial variation of various processes in subduction zones, including interplate seismic activities and evolution of the forearc structure.
Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties
Authors: Chen Ying , Wang Xing , Tao Sheng , Wang Qi , Ma Pan-Qin , Li Zi-Biao , Wu Yun-Long , Li Da-Wei 
Published: August 2023

AbstractThe treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating diabetic wounds due to their excellent hydrophilicity, good drug-loading ability and sustained drug release properties. As a typical example, hyaluronic acid dressing (Healoderm) has been demonstrated in clinical trials to improve wound-healing efficiency and healing rates for diabetic foot ulcers. However, the drug release and degradation behavior of clinically-used hydrogel wound dressings cannot be adjusted according to the wound microenvironment. Due to the intricacy of diabetic wounds, antibiotics and other medications are frequently combined with hydrogel dressings in clinical practice, although these medications are easily hindered by the hostile environment. In this case, scientists have created responsive-hydrogel dressings based on the microenvironment features of diabetic wounds (such as high glucose and low pH) or combined with external stimuli (such as light or magnetic field) to achieve controllable drug release, gel degradation, and microenvironment improvements in order to overcome these clinical issues. These responsive-hydrogel dressings are anticipated to play a significant role in diabetic therapeutic wound dressings. Here, we review recent advances on responsive-hydrogel dressings towards diabetic wound healing, with focus on hydrogel structure design, the principle of responsiveness, and the behavior of degradation. Last but not least, the advantages and limitations of these responsive-hydrogels in clinical applications will also be discussed. We hope that this review will contribute to furthering progress on hydrogels as an improved dressing for diabetic wound healing and practical clinical application.
Bioengineered skin organoids: from development to applications
Authors: Hong Zi-Xuan , Zhu Shun-Tian , Li Hao , Luo Jing-Zhi , Yang Yu , An Yang , Wang Xi , Wang Kai 
Published: August 2023

AbstractSignificant advancements have been made in recent years in the development of highly sophisticated skin organoids. Serving as three-dimensional models that mimic human skin, these organoids have evolved into complex structures and are increasingly recognized as effective alternatives to traditional culture models and human skin due to their ability to overcome the limitations of two-dimensional systems and ethical concerns. The inherent plasticity of skin organoids allows for their construction into physiological and pathological models, enabling the study of skin development and dynamic changes. This review provides an overview of the pivotal work in the progression from 3D layered epidermis to cyst-like skin organoids with appendages. Furthermore, it highlights the latest advancements in organoid construction facilitated by state-of-the-art engineering techniques, such as 3D printing and microfluidic devices. The review also summarizes and discusses the diverse applications of skin organoids in developmental biology, disease modelling, regenerative medicine, and personalized medicine, while considering their prospects and limitations.
Using remotely delivered Spring Forest Qigong™ to reduce neuropathic pain in adults with spinal cord injury: protocol of a quasi-experimental feasibility clinical trial
Authors: Van de Winckel Ann , Carpentier Sydney , Deng Wei , Zhang Lin , Battaglino Ricardo , Morse Leslie 
Published: August 2023

Abstract
Background
About 69% of Americans living with spinal cord injury (SCI) suffer from long-term debilitating neuropathic pain, interfering with the quality of daily life. Neuropathic pain is refractory to many available treatments—some carrying a risk for opioid addiction—highlighting an urgent need for new treatments. In this study, we will test our hypothesis that Spring Forest Qigong™ will reduce SCI-related neuropathic pain by improving body awareness. We will determine whether remotely delivered Qigong is feasible and we will collect data on neuropathic pain, and other reported associations with pain such as spasms frequency and/or severity, functional performance, mood, and body awareness.

Methods
In this quasi-experimental pilot clinical trial study, adults with SCI will practice Qigong at home with a 45-min video, at least 3 × /week for 12 weeks. The Qigong practice includes movements with guided breathing and is individualized based on functional abilities, i.e., the participants follow along with the Qigong movements to the level of their ability, with guided breathing, and perform kinesthetic imagery by focusing on the feeling in the whole body as if doing the whole-body Qigong movement while standing. The highest, average, and lowest neuropathic pain ratings perceived in the prior week will be recorded weekly until the 6-week follow-up. The other outcomes will be collected at 5 time points: at baseline, midway during the Qigong intervention (6 weeks), after the Qigong intervention (12 weeks), after a 6-week and 1-year follow-up. Rate parameters for the feasibility markers will be estimated based on the participants who achieved each benchmark.

Discussion
The University of Minnesota (UMN)’s Institutional Review Board (IRB) approved the study (IRB #STUDY00011997). All participants will sign electronic informed consent on the secure UMN REDCap platform. The results will be presented at academic conferences and published in peer-reviewed publications.

Trial registration
ClinicalTrial.gov registration number: NCT04917107, (this protocol paper refers to the substudy), first registered 6/8/2021.
3D biofabrication of diseased human skin models in vitro
Authors: Ahn Minjun , Cho Won-Woo , Park Wonbin , Lee Jae-Seong , Choi Min-Ju , Gao Qiqi , Gao Ge , Cho Dong-Woo , Kim Byoung Soo 
Published: August 2023

Abstract

Human skin is an organ located in the outermost part of the body; thus, it frequently exhibits visible signs of physiological health. Ethical concerns and genetic differences in conventional animal studies have increased the need for alternative in vitro platforms that mimic the structural and functional hallmarks of natural skin. Despite significant advances in in vitro skin modeling over the past few decades, different reproducible biofabrication strategies are required to reproduce the pathological features of diseased human skin compared to those used for healthy-skin models. To explain human skin modeling with pathological hallmarks, we first summarize the structural and functional characteristics of healthy human skin. We then provide an extensive overview of how to recreate diseased human skin models in vitro
,
including models for wounded, diabetic, skin-cancer, atopic, and other pathological skin types. We conclude with an outlook on diseased-skin modeling and its technical perspective for the further development of skin engineering.
ARGONAUTE 1: a node coordinating plant disease resistance with growth and development
Authors: Zhao Zhi‑Xue , Yang Si-Jia , Yin Xiao-Xiao , Yan Xiu-Lian , Hassan Beenish , Fan Jing , Li Yan , Wang Wen-Ming 
Published: August 2023

AbstractArgonaute (AGO) proteins are highly conserved and widely distributed across various organisms. They mainly associate with small RNAs (sRNAs) and act as integral players of the RNA-induced silencing complex in the RNA interference (RNAi) pathway, regulating gene expression at transcriptional and post-transcriptional levels, thereby mounting diverse fine-tuning functions in a variety of biological processes. Since the discovery and functional characterization of the first AGO in Arabidopsis, our understanding of the functions of AGO proteins has grown rapidly throughout the plant kingdom. AGO1 attracts investigators’ attention because it forms an autoregulatory loop with miR168 and associates with other endogenous sRNAs and cross-kingdom exogenous sRNAs to relay all-round functions. AGO1 associates with endogenous sRNAs that form a complicated regulatory network via targeting a large body of downstream genes involved in growth, development, and stress-induced responses. Host AGO1 may also be exploited by cross-kingdom exogenous sRNAs generated by parasitic organisms to facilitate their colonization via suppressing host defense genes. Moreover, many pathogenic microbes directly target host AGO1 to facilitate their infection via suppression of the host RNAi pathway. Thus, we focus on plant AGO1 and provide an overview of our current understanding of the roles of AGO1 in the coordination of plant disease resistance with growth and development. We also discuss the perspectives in the dissection of the AGO1-mediated signal transduction pathway.
Static aeroelasticity analysis of a rotor blade using a Gauss-Seidel fluid-structure interaction method
Authors: Li Jiaxing , Luo Jiaqi , Liu Yaolong , Han Zhonghua 
Published: August 2023

AbstractThe present study introduces a Gauss-Seidel fluid-structure interaction (FSI) method including the flow solver, structural statics solver and a fast data transfer technique, for the research of structural deformation and flow field variation of rotor blades under the combined influence of steady aerodynamic and centrifugal forces. The FSI method is illustrated and validated by the static aeroelasticity analysis of a transonic compressor rotor blade, NASA Rotor 37. An improved local interpolation with data reduction (LIWDR) algorithm is introduced for fast data transfer on the fluid-solid interface of blade. The results of FSI calculation of NASA Rotor 37 show that when compared with the radial basis function (RBF) based interpolation algorithm, LIWDR meets the interpolation accuracy requirements, while the calculation cost can be greatly improved. The data transmission time is only about 1% of that of RBF. Moreover, the iteration step of steady flow computation within one single FSI has little impact on the converged aerodynamic and structural results. The aerodynamic load-caused deformation accounts for nearly 50% of the total. The effects of blade deformation on the variations of aerodynamic performance are given, demonstrating that when static aeroelasticity is taken into account, the choke mass flow rate increases and the peak adiabatic efficiency slightly decreases. The impact mechanisms on performance variations are presented in detail.
Management of a rare isolated left main coronary artery ostial stenosis in a young patient: a case report
Authors: Buck Johanna M. , Schramm René , Renner André , Gummert Jan F. , Guenther Sabina P. W. 
Published: August 2023

Abstract
Background
Isolated congenital ostial stenosis of the left coronary artery (LCA) is extremely rare, and available literature is limited. Long-term treatment success is key in the choice of treatment strategy due to the mostly young age of the patients. Here, we present a clinical case and shed light on the surgical treatment strategies including their pitfalls.

Case presentation
We describe a 20-year-old male who presented to the emergency department with recurrent typical angina pectoris symptoms (CCS class II). Computed tomography and coronary angiography revealed isolated ostial stenosis of the LCA, with prominent collaterals from the right coronary artery. The patient was operated on and intra-operative findings showed a severely narrowed LCA ostium that appeared to be fibrotic, and to originate from a similarly fibrotic left coronary sinus of the aortic root. The LCA was excised from the left coronary sinus, and trimmed until the coronary artery lumen appeared macroscopically normal. The fibrotic left coronary sinus was resected and replaced with a bovine pericardial patch, into which the coronary artery was re-inserted. During weaning from cardiopulmonary bypass, we faced a diminished left ventricular function. We attributed this to insufficient myocardial protection. Isolated antegrade cardioplegia had been used, which, for technical reasons, had to be administered separately to the right and left coronary artery after aortotomy. In the setting of huge collaterals from the right to the left coronary artery, a steal-effect likely occurred. After prolonged reperfusion, the left ventricular function recovered, and the further post-operative course was unremarkable.

Conclusions
For the surgical treatment of congenital ostial stenosis of the LCA, both ostium reconstruction and coronary artery bypass grafting have been described. The advantage of ostium reconstruction as chosen here is to create a physiological flow and supply situation to the affected myocardial areas. Furthermore, in case of other downstream events, such as the development of coronary artery disease, all further therapeutic options are preserved.
Special attention should be paid to the administration of cardioplegia in these patients. Combined ante and retrograde cardioplegia administration probably would have achieved more extensive myocardial protection in our case.
Comparison of the outcomes of endoscopic versus microscopic approach in cholesteatoma surgery: a randomized clinical study
Authors: Hamela Mo’men Ali Ameen , Abd-Elnaseer Osama , El-Dars Mohamed Monir , El-Antably Adel 
Published: August 2023

Abstract
Background
Endoscopic ear surgery is a new, less invasive otologic procedure. Since 1990s, it has been grown in prominence because of anatomical and physiological theories. It offers a view of hidden places, avoids mastoidectomies and endaural vertical and postauricular incisions, and has many other benefits over microscopic surgery. The purpose of this study was to distinguish the difference between the outcomes of microscopic and endoscopic cholesteatoma surgery.

Methods
Eighty individuals who were diagnosed with cholesteatoma participated in this randomized clinical research. Patients were randomly allocated into two equivalent treatment groups. One group submitted to tympanoplasty via microscopic ear surgery and the other group had exclusive trans-canal endoscopic ear surgery. All patients had preoperative otomicroscopic and radiologic assessment to ensure cholesteatoma diagnosis. Audiological evaluations were also obtained.

Results
There was no discernible difference in the tested groups’ operational times, air-bone gaps, or air conduction. The endoscopic surgery group healed significantly more quickly than the microscopic surgery group (5.4 0.5 vs 7.7 0.5 weeks, p > 0.001). The frequency of residual lesions (5.0% vs 22.5%, p = 0.023) and recurrence (7.5% vs 27.5%, p = 0.019) was significantly lower in the endoscopic group of patients.

Conclusions
When comparing healing times, rates of residual disease and rates of recurrence, endoscopic surgery clearly outperforms microscopic surgery. The endoscope encourages visualization and magnification of anatomy while being less invasive thanks to its improved picture quality, lighting, and capacity to “see around the corner.” Additionally, a significant portion of viable mastoid tissues and healthy mucosa were preserved.
Central auditory processing abilities in individuals with tinnitus and normal hearing sensitivity: a systematic review
Authors: S. Sanjay , Vinod Vibha , Jain Chandni 
Published: August 2023

Abstract
Background
Tinnitus is the perception of sound when there is no external sound stimulus. Individuals with tinnitus may have altered neurological system corresponding to the auditory pathway. Therefore, central auditory processing abilities, which rely on the central auditory pathway, may be affected. This study reviewed the published studies regarding the impact of tinnitus on central auditory processing abilities.

Main text
A total of 3087 studies were identified, of which 18 fulfilled the eligibility criteria and were included in the review. The included studies scored good or fair in the quality assessment checklist. The review showed that individuals who had tinnitus with normal hearing sensitivity performed poorly on temporal resolution tests, speech perception in noise, localization, and auditory memory. However, temporal patterning and dichotic tests were not shown to be affected by tinnitus.

Conclusion
The audiologists involved in tinnitus assessment are recommended to include central auditory processing tests in routine evaluation for the early diagnosis and intervention for subjects with tinnitus.
Laser drilling: reviewing the effect of purging system and formation parameters
Authors: ElNeiri Mohamed Hosin , Dahab Abdel Sattar Abdel Hamid , Abdulaziz Abdulaziz Mohamed , Abdelghany Khalid Mahmoud 
Published: August 2023

AbstractLaser drilling is capable of reducing drilling costs and time. In laser drilling, a high rate of penetration (ROP) can be achieved, and the hole is cased due to laser interaction once it is drilled. In addition, laser technology can substitute conventional perforation techniques with no formation damage. Rock cutting with a laser beam is affected by various variables that fall within three categories; the rock parameters, purging system and experimental setup, and laser parameters. Each set of these categories affects the rock lasing process. Formation parameters include rock type, sample size, orientation, and the type of fluids saturating the rock sample. The purging system parameters include the type of purging system, application parameters, and the purging medium. Laser parameters involve laser type, laser application mode, beam power, duration, intensity, and frequency.This paper reviews several experimental works performed by institutes, researchers, and entities to provide the reader with a comprehensive knowledge base for further experimental work, modeling for laser drilling, and studies. Because performed laser drilling experimental work is huge and covers tremendous aspects, only the purging system and effect of formation parameters were considered in this review, while laser parameters will be presented in a later paper. Results showed that the laser can drill swiftly through all rock types in conventional vertical, directional, or horizontal drilling. For optimum laser drilling, the purging system and its parameters must be carefully chosen, including the type of system, purging gas, gas pressure, distance to the lased sample surface, and the purging angle. The optimum purging system uses nitrogen as a purging fluid.
Adding Ovarian Suppression to Tamoxifen for Premenopausal Women With Hormone Receptor–Positive Breast Cancer After Chemotherapy: An 8-Year Follow-Up of the ASTRRA Trial
Authors: Baek Soo Yeon , Noh Woo Chul , Ahn Sei-Hyun , Kim Hyun-Ah , Ryu Jai Min , Kim Seung Il , Lee Eun-Gyeong , Im Seock-Ah , Jung Yongsik , Park Min Ho , Park Kyong Hwa , Kang Su Hwan , Jeong Joon , Park Eunhwa , Kim Sung Yong , Lee Min Hyuk , Kim Lee Su , Lim Woosung , Kim Seonok , Kim Hee Jeong 
Published: August 2023

PURPOSE To determine the updated long-term outcomes of the Addition of Ovarian Suppression to Tamoxifen in Young Women With Hormone-Sensitive Breast Cancer Who Remain Premenopausal or Regain Vaginal Bleeding After Chemotherapy (ASTRRA) trial. PATIENTS AND METHODS This study is a post-trial follow-up of the ASTRRA trial, involving 1,483 premenopausal women younger than 45 years treated with definitive surgery after completing adjuvant or neoadjuvant chemotherapy for estrogen receptor–positive breast cancer. Patients were randomly assigned in a 1:1 ratio to complete 5 years of tamoxifen (TAM) alone (TAM-only) or 5 years of TAM with ovarian function suppression (OFS) for 2 years (TAM + OFS). The primary end point was disease-free survival (DFS), and the secondary end point was overall survival (OS). RESULTS At 106.4 months of median follow-up, there was a continuous significant reduction in the DFS event rate in the TAM + OFS group. The 8-year DFS rate was 85.4% in the TAM + OFS group and 80.2% in the TAM-only group (hazard ratio [HR], 0.67; 95% CI, 0.51 to 0.87). There were no significant differences in OS between the two groups. The OS rate was 96.5% in the TAM + OFS group and 95.3% in the TAM-only group (HR, 0.78; 95% CI, 0.49 to 1.25). CONCLUSION Adding OFS for 2 years to adjuvant TAM with a longer follow-up resulted in consistent DFS benefits, suggesting that adding OFS to TAM should be considered for patients who remain in a premenopausal state or resume ovarian function after chemotherapy.