bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacogenomics—a New Frontier for Individualized Treatment of Parkinson’s
Disease
Authors: Liu Jia-Si , Chen Ying , Shi Dan-Dan , Zhang Bao-Rong , Pu Jia-Li 
Published: December 2022

Background:
Parkinson’s disease (PD) is the second most common neurodegenerative disease
with a significant public health burden. It is characterized by the gradual degeneration of dopamine
neurons in the central nervous system. Although symptomatic pharmacological management remains
the primary therapeutic method for PD, clinical experience reveals significant inter-individual
heterogeneity in treatment effectiveness and adverse medication responses. The mechanisms behind
the observed interindividual variability may be elucidated by investigating the role of genetic variation
in human-to-human variances in medication responses and adverse effects.

Objective:
This review aims to explore the impact of gene polymorphism on the efficacy of antiparkinsonian
drugs. The identification of factors associated with treatment effectiveness variability might
assist the creation of a more tailored pharmacological therapy with higher efficacy, fewer side outcomes,
and cheaper costs.

Methods:
In this review, we conducted a thorough search in databases such as PubMed, Web of Science,
and Google Scholar, and critically examined current discoveries on Parkinson's disease pharmacogenetics.
The ethnicity of the individuals, research methodologies, and potential bias of these
studies were thoroughly compared, with the primary focus on consistent conclusions.

Results:
This review provides a summary of the existing data on PD pharmacogenetics, identifies its limitations,
and offers insights that may be beneficial for future research. Previous studies have investigated
the impact of gene polymorphism on the effectiveness and adverse effects of levodopa. The trendiest
genes are the COMT gene, DAT gene, and DRD2 gene. However, limited study on other anti-Parkinson's
drugs has been conducted.

Conclusion:
Therefore, In order to develop an individualized precision treatment for PD, it is an inevitable
trend to carry out multi-center, prospective, randomized controlled clinical trials of PD pharmacogenomics
covering common clinical anti-PD drugs in large, homogeneous cohorts.
Preventive Effects of Achillea Millefolium, Rosa Damascena and Origanum
Majorana Hydroalcoholic Extracts on Breast Cancer in Female Mice
Authors: Nabatchian Fariba , Ashtiani Mojtaba , Teimourpour Amir , Davoudi Negin , Niknam Sara , Afrisham Reza 
Published: December 2022

Introduction:
Breast cancer is overall considered the second most frequently recognized
cancer worldwide. Several studies have recently reported the antitumoral properties of some
medicinal herbs such as Yarrow (Achillea millefolium), Marjoram (Origanum majorana), and Rose
(Rosa damascena Mill L). Therefore, the current study aimed to evaluate the effect of the
hydroalcoholic extract of these plants on breast cancer prevention in female mice.

Methods:
Mice were classified into five ten‐mice groups: normal control (untreated group), tumor
group (treated with 4T1 cells), and treatment groups (treated with 4T1 cells+ Yarrow or Rose and
Marjoram plants). Then, the levels of cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen
(CEA), superoxide dismutase (SOD), and total antioxidants were determined. Finally, the tumor size
was evaluated.

Results:
The hydroalcoholic extract of Yarrow herb significantly decreased the levels of CA-15-3
and CEA (P-value = 0.008 and P-value = 0.018, respectively). In addition, hydroalcoholic extracts of
Yarrow, Rose, and Marjoram plants significantly reduced tumor size in comparison with the tumor
group (P-value < 0.001 for Yarrow, and P-value = 0.004 for Rose and Marjoram plants). Yarrow
herb had the significantly highest effect on tumor size in comparison with Rose and Marjoram plants
(P-value = 0.011 for both plants). However, no significant differences were found among the groups
treated with the plants in comparison with the tumor mice in terms of SOD and total antioxidants (Pvalue
> 0.05).

Conclusion:
Our findings revealed that A. millefolium had the greatest antitumor effects on mice
with breast cancer in comparison with O. majorana and R. damascena herbs. However, more
complementary studies are needed in this regard.
High Value Compounds and Bioactivity of Rice Bran, Rice Bran Protein:
A Review
Authors: Kalita Pratap , Ahmad Abdul Baquee , Sen Saikat , Deka Bhargab , Hazarika Quri Kiran , Kapil Manas Jyoti , Pachuau Lalduhsanga 
Published: December 2022

Abstract:
Rice bran and rice bran protein are important sources of minerals, energy, and vitamins.
Other bioactive compounds are abundantly available to exert therapeutical activity. Healthpromoting
activities of high-value compounds of rice bran were significant, as observed in recent
studies. A variety of bioactive components present in rice bran and rice bran extract are responsible
to exhibit therapeutical potential like chemopreventive, cardioprotective, hepatoprotective,
immunomodulatory, neuroprotective, and lipid-lowering activity. Several bioactivity representative
compounds like γ-oryzanol, ferulic acid, caffeic acid, tricin, protocatechuic acid, vanillic acid,
coumaric acid, phytic acid, isoferulic acid, gallic acid, γ-amino butyric acid, sinapic acid, saturated
and unsaturated fatty acids, vitamin E complexes, β-sitosterol, stigmasterol, campesterol,
cyanidin-3-glucoside, peonidin-3-glucoside, quercetin, rutin, kaemferol, β-carotene, lutein, vitamin
B and lycopene are known to display significant health benefits. The bioactive components
produced therapeutical effects by regulation of different mechanisms like increasing faecal excretion,
reducing oxidative stress, reducing the level of malondialdehyde (MDA), regulation of
NF-kb activation, reduction of proinflammatory cytokines production, suppression of SREBP-1,
reduction in the expression of anti-apoptotic protein Bcl-2, elevated the expression of proapoptotic
protein Bax, up-regulating P53 expression and suppressing COX-2. Several research
engines like PubMed, google scholar, science direct, etc. were used to collect the data on the mentioned
keywords. Recent scientific works were included in this article. In this review paper, we
profiled the high-value compounds and focused on their antioxidant, anti-hyperlipidemic, antidiabetic,
and anticancer activity with their possible mechanism of action.
Physiological and Psychological Effects of Parent-Delivered Traditional Thai Massage in Children With Autism: Protocol for a Randomized Controlled Trial
Authors: Ruan Hui , Eungpinichpong Wichai , Wu Hua , Aonsri Chanada 
Published: December 2022

Background
Although many autistic children receive massage as a complementary therapy, it is not included in evidence-based practice for autism because evidence of its efficacy is lacking. Further, prior studies have failed to identify objective indicators of core symptoms or elucidate their mechanisms.

Objective
We developed a parent-delivered traditional Thai massage (TTM) intervention for children with autism, aiming to experimentally determine whether children with autism truly experience positive effects from parent-delivered TTM and determine possible mechanisms of the observed effects.

Methods
A 2-armed, parallel randomized controlled trial was conducted between February 2022 and June 2022. Forty-eight children with autism (aged 7-12 years) were recruited from the Hainan Special Education School and randomly assigned to either a parental TTM or control group at a ratio of 1:1 based on random numbers generated with Online Research Randomizer. The generated sequences were concealed in an opaque envelope. Individuals in the parental TTM group received 16 parent-delivered TTM sessions over 8 weeks at the school’s health room after school, and the control group maintained a normal daily routine. Outcomes were assessed on admission, after 8 weeks, and at a 2-month follow-up and included the effect of massage treatment on autism symptoms, measured with the Autism Treatment Evaluation Checklist score (evaluated by parents and a blinded teacher), physiological parameters (ie, heart rate variability and gait), and the Parenting Stress Index, Fourth Edition–Short Form.

Results
We finished all data collection on June 20, 2022. Data analysis will be started, and we expect to publish results in 2023.

Conclusions
This study will provide further evidence for massage treatment of autism and provide support for family-based care.

Trial Registration
Chinese Clinical Trial Registry ChiCTR2100051355; https://tinyurl.com/3dwjxsw5

International Registered Report Identifier (IRRID)
DERR1-10.2196/41839
Leucemia plasmocitária primária: relato de caso e revisão sistemática sobre seus fatores prognósticos
Authors: Couto Maria Carolina Barreto Moreira , Almeida Lara Maria Carneiro de , Almeida Mariane Carvalho de , Oliveira Janine Magalhães Garcia de 
Published: December 2022

A leucemia de células plasmocitárias (LCP) é uma neoplasia hematológica rara, de caráter agressivo, ainda sem consenso quanto ao melhor esquema terapêutico e prognóstico da doença. Alguns estudos a consideram como uma variante do mieloma múltiplo. O objetivo deste estudo foi realizar um relato de caso e desenvolver uma revisão sistemática da literatura sobre os fatores prognósticos relacionados a essa enfermidade. Esta revisão sistemática seguiu o protocolo PRISMA, utilizou o PubMED como base de dados, buscando estudos que avaliassem fatores prognósticos da LCP. Os estudos selecionados foram posteriormente avaliados quanto a sua qualidade pelo protocolo STROBE. A primeira busca identificou 260 artigos. Após aplicado critério de exclusão, dez foram selecionados. Destes, oito avaliaram fatores prognósticos clínicos e laboratoriais; cinco avaliaram, além disso, fatores citogenéticos; e um avaliou apenas a idade como fator prognóstico. A qualidade dos estudos, avaliada pelo protocolo STROBE, apresentou uma classificação média de 79,1%. Nos estudos analisados, idade > 65 ou > 60 anos, performance status ECOG > 2, hipercalcemia, aumento de lactato desidrogenase (LDH), aumento da creatinina, plaquetopenia e hipoalbuminemia foram encontrados como preditores de prognóstico ruim. Foram também demonstradas alterações citogenéticas consideradas de alto risco, como as translocações e deleções de genes. Diversas condições clínicas, laboratoriais e citogenéticas parecem estar associadas ao pior prognóstico na LCP. O conhecimento desses fatores pode interferir na prática clínica. Entretanto, ainda são necessários estudos mais robustos, multicêntricos e com maior número amostral para aprofundar o conhecimento sobre essa patologia.
DYNAMIC MODEL OF BEAM DEFORMATION WITH CONSIDER NONLOCAL IN TIME ELASTIC PROPERTIES OF THE MATERIAL
Authors: Sidorov Vladimir , Badina Elena , Tsarev Roman 
Published: December 2022

In this paper, the problem of numerical dynamic calculation of a beam made of composite material with a developed internal structure is considered. The elastic properties are assumed to be nonlocal in time. A short review of the existing methods for mathematical modeling of the dynamic behavior of elements with a developed internal structure was carried out. A non-local in time model of dynamic deformation of a bending beam is constructed. Since the finite element analysis (FEA) is the most demanded numerical method for mechanical systems analysis, a non-local dynamic deformation model is integrated into the algorithm of this method. The equilibrium equation of the structure in motion is solved by an explicit scheme. The damping matrix is obtained from the condition of stationarity of the total deformation energy of a moving mechanical system. A one-dimensional non-local in time model was implemented in the MATLAB software package.
LA ACUSACIÓN CONSTITUCIONAL A AUTORIDADES REGIONALES Y PROVINCIALES EN LA CONSTITUCIÓN DEL 80
Authors: Boffil Chávez Eduardo 
Published: December 2022

La Constitución de 1980 crea y regula las autoridades que ejercen el gobierno y la administración, tanto en las regiones como en las provincias. A lo largo de su vigencia se verifican tres momentos. Primeramente, la Carta originaria suponía una regulación que contaba con Intendentes y Gobernadores como principales autoridades. Luego este diseño fue reformado en parte por la Ley Nº 19.097 que creó al Gobierno Regional. Finalmente, con la Ley Nº 20.990 se vislumbran cambios importantes: se eliminan los cargos de Intendente y Gobernador, pasando a existir los Delegados Presidenciales, tanto regionales como provinciales, así como un Gobernador Regional, el cual es elegido popularmente.
Desde el origen de la Carta, los Intendentes y Gobernadores eran acusables constitucionalmente por infracción de la Constitución y por los delitos de traición, sedición, malversación de fondos públicos y concusión. La Ley Nº 20.990 reemplazó a estos sujetos pasivos por los Delegados Presidenciales, tanto regionales como provinciales. Sin embargo, el constituyente derivado incurrió en una inconsistencia al regular la acusación del Gobernador Regional, que la hace inaplicable.
Tantangan Kebijakan Satu Data Indonesia
Authors: Ardani Irfan , Cahyani Heti Sri Hari 
Published: December 2022

Accurate vital statistics can be used to formulate health programs and policies. The problem is the overlapping and fragmented data sources in several agencies that record data on deaths and causes of death. The Indonesia’s One Data policy was created to organize the data generated by each agency that performs public data collection, recording and reporting. The purpose of this study is to examine the challenges of implementing the Indonesia’s One Data policy in the registration system of deaths and causes of death in DKI Jakarta Province. Data analysis uses the World Wide Web Foundation's framework of data openness, including legal frameworks, political barriers, coordination, and data quality. This study found that there are many regulations regarding data integration, but there are still overlaps in the recording and reporting systems. Coordination between agencies and political egos of each agency affect the quality of the data produced. In conclusion, weak coordination and sectoral political egos are still obstacles to implementing the One Data Indonesia policy. This study suggests eliminating data fragmentation and conducting data interoperability so that it is more accurate to use as a basis for policymaking.
Abstrak
Statistik hayati kematian dan penyebab kematian yang akurat dapat dimanfaatkan sebagai dasar penyusunan program dan kebijakan kesehatan berbasis bukti. Permasalahan yang ada adalah sumber data yang tumpang tindih dan terfragmentasi di beberapa instansi yang melakukan fungsi pencatatan data kematian dan penyebab kematian. Kebijakan Satu Data Indonesia dibuat untuk mengorganisir data yang dihasilkan oleh setiap instansi yang melakukan pengumpulan, pencatatan dan pelaporan data publik. Tujuan penelitian ini mengkaji gambaran tantangan implementasi kebijakan Satu Data Indonesia pada sistem pencatatan kematian dan penyebab kematian di Provinsi DKI Jakarta. Analisis data menggunakan teori menurut World Wide Web Foundation tentang keterbukaan data yang terdiri dari variabel legal framework, political barriers, koordinasi, serta kualitas data. Hasil penelitian ini menemukan dari sisi regulasi telah banyak diatur tentang integrasi data, tetapi masih ada tumpang tindih sistem pencatatan dan pelaporan. Koordinasi antar instansi dan ego politik masing-masing instansi berpengaruh pada kualitas data yang dihasilkan. Kesimpulannya, hambatan koordinasi dan ego politik sektoral masih menjadi kendala dalam pelaksanaan kebijakan Satu Data Indonesia. Penelitian ini menyarankan untuk membuka fragmentasi data dan melakukan koordinasi interoperabilitas data sehingga data yang dihasilkan lebih akurat untuk digunakan sebagai dasar pembuatan kebijakan.
KEJADIAN DEMAM BERDARAH DENGUE (DBD) DI INDONESIA TAHUN 2010-2019
Authors: Arisanti Maya , Suryaningtyas Nungki Hapsari 
Published: December 2022

Dengue Haemorrhagic Fever (DHF) control focuses on preventation efforts with the mosquito nest eradication movement (PSN). The larva free number (ABJ) is an indicator of the success of PSN and early prevention by ensuring a negative house with Aedes sp. This research is descriptive used secondary data on Indonesia’s health profile in 2010-2019. This study describes cases of DHF, incidence rate and larva free rate (ABJ) for 10 years. The results showed that DHF cases in Indonesia from 2010-2019 fluctuating where the higehest cases occurred in 2016 which was 204.171 cases and the lowest occurred in 2018 which was 65.602 cases. The highest incidence of DHF occurred in 2016 which was 78,85 per 100.000 population. Indonesia’s ABJ for 10 years is still below the target <95% in the range 24,1-80,2%. Transmission of DHF still occurs in Indonesia, this can be seen from the still finding cases of DHF every year and indicators of morbidity due to DHF which is still high above 49 per 100.000 population. The low ABJ affects the occurrence of dengue cases in Indonesia.
TINDAK LANJUT TERHADAP PENERAPAN ELEKTRONIK VOTING DALAM PELAKSANAAN PEMILIHAN KEPALA DAERAH BERDASARKAN PERATURAN PERUNDANG-UNDANGAN
Authors: Willia Saputra Beni , Johan Nasution Bahder 
Published: December 2022

The thesis focuses on determining the application of Electronic Voting used for the General Election of Regional Heads in Indonesia. Electronic Voting is a system that utilizes electronic devices and processes digital information to create ballots, cast votes, calculate vote acquisitions, display vote acquisitions and maintain and generate audit trails. E-voting is considered to be applied for utilization on the scale of General Elections to Regions that one may achieve election effectiveness and efficiency. Aside from that, it can decrease costs of realization, shorten the voting time to the vote-counting process, and certain other advantages obtained from the realization of Electronic Voting. The problem of this research is how to follow up the juridical regulation on the realization of e-voting in the utilization of Regional Head Election based on the laws and regulations in Indonesia, furthermore find out the legal problems of implementing e-voting in the Regional Head Election in Indonesia. The type of research used is normative juridical, namely legal research methods execute by examining library materials or secondary materials. The previous section has broadly described that there is a vacuum of Electronic Voting system in the application of the General Election to the Regions. After all, there is no KPU regulation whichever would be used as the basis for applying this Electronic Voting system, as much as this system demand to be reviewed It be implemented yet because there are deficiencies in the application of the Electronic Voting System process that would eventually fail the implementation.
novos percursos do fotojornalismo
Authors: Leitão Juliana Andrade 
Published: December 2022

Este artigo se propõe a refletir sobre quais caminhos o fotojornalismo está traçando para se manter relevante e atento às críticas que dizem respeito, principalmente, às práticas que envolvem a captura das imagens de notícias. O que desencadeou as discussões aqui levantadas foi o anúncio do Prêmio do Ano do World Press Photo, que diz o seguinte: “Pela primeira vez nos 67 anos de história do World Press Photo, o World Press Photo of the Year é uma fotografia sem pessoas”. A discussão utiliza principalmente Susan Sontag, Ariella Azoulay e Charlotte Cotton para problematizar a imagem fotográfica que possui um grande impacto dentro da sociedade e não está impune às questões de conflitos de narrativas e desinformação como qualquer outra forma de linguagem. O prêmio evidencia uma forma de narrar as histórias fora de um padrão estabelecido e reforçado ao longo da história do fotojornalismo, colocando em questão um debate sobre alteridade.
Pterygium Surgery: Autologous Blood or Suture for Conjunctival Autografting?
Authors: Akioud Wafae , Hamzi Abderrahmane , Khamaily Mehdi , Mozarie Yassine , Oubaaz Abdelbare 
Published: December 2022

Purpose: The aim of our study is to compare two different techniques for conjunctival autografting: surgical suturing and autologous blood coagulum.

Methods: In this prospective study, we randomly divided 30 patients with primary pterygium into two groups similar in matter of age and sexe distribution. Group 1 underwent surgical suturing for conjunctival autografting and Group2 underwent sutureless autologous blood coagulum for that matter. We evaluated the primary outcome in terms of operative time, patients’ discomfort, graft displacement, graft failure and recurrences. The follow-up rate was at day1, week 1, month 1, 3 months and 6 months.

Results: The operative time and patients’ discomfort were considerably reduced using the blood coagulum method (Operative time :15±3 minutes for Group 2 versus 32±2 minutes for Group1) (Patients discomfort p value <0.001). The graft failure and displacement were, however, higher in Group 2 compared to the first Group (p value for both is <0.001). The recurrence rate was equal in both groups.

Conclusion: The use of autologous blood coagulum for conjunctival autografting is less time consuming and more comfortable for patients. However, the graft failure and displacement are more common with this technique.
Sejarah Konversi Khalifah Al-Rasul Menjadi Khalifatullah
Authors: Khoiri Mif Tahul 
Published: December 2022

AbstrakArtikel ini membahas sejarah konversi khalifah al-rasul menjadi khalifatullah, yang mana, dalam perjalanan sejarah Islam pasca wafatnya rasulullah, kepemimpinan dalam Islam mengalami beberapa kali pergantian. Setelah rasulullah wafat, kepemimpinan di kendalikan oleh empat sahabat nabi, yakni Abu Bakar As-Shidiq, Umar Bin Khattab, Utsman Bin Affan, dan Ali Bin Abi Tholib. Yang mana keempat sahabat ini dikenal dengan sebutan Khulafaur Rasyidin. Pasca kepemimpinan khulafaur rasyidin, kepemimpinan selanjutnya beralih ke Dinasti Umayyah yang terdiri dari empat belas pemimpin. Kemudian setelah dinasti Umayyah tumbang, munculah kepemimpinan Dinasti Abbasiyah yang dipimpin oleh 37 pemimpin. Yang mana dari munculnya dinasti abbasiyah inilah gejolak selain khalifah Abu al-Abbas al-Saffah, konversi dari khalifah al-rasul menjadi khalifatullah mulai tampak. Di akhir berdirinya dinasti abbasiyah tersebut, ketika abbasiyah mulai lemah, berdirilah dua kekhalifahan yakni, kekhalifahan Fatimiyah di Afrika Utara dan kekhalifahan Dinasti umayyah II Andalusia.Kata kunci: Sejarah, Konversi, Khalifah al-rasul, khalifatullah. AbstractThis article discusses the history of conversion of the caliph of al-rasul to khalifatullah. Which, in the course of Islamic history after the death of the apostle, leadership in Islam experienced several changes. After the Prophet's death, leadership was handled by four Companions of the Prophet, Abu Bakr As-Shidiq, Umar Bin Khattab, Utsman Bin Affan, and Ali Bin Abi Tholib. Which these four friends are known as Khulafaur Rasyidin. After the rulership of khulafaur rasyidin, the leadership then shifted to the Umayyad Dynasty consisting of fourteen leaders. Later after the Umayyad dynasty collapsed, the leadership of the Abbasid Dynasty led by 37 leaders. Which of the emergence of this abbasiyah dynasty is the turmoil besides Caliph Abu al-Abbas al-Saffah, the conversion of the caliph al-rasul to khalifatullah began to appear. At the end of the abbasiyah dynasty, when abbasiyah began to weaken, stood two caliphate namely, the Fatimid caliphate in North Africa and the Caliphate of the umayyah Dynasty of Andalusia II.Keywords: History, Conversion, Caliph al-rasul, khalifatullah.