bluuebunny/crossref_metadata_2025_split huggingface dataset:
Segmented spin‐echo echo‐planar imaging improves whole‐brain BOLD functional MRI in awake pigeon brains
Authors: Khodadadi Mina , Helluy Xavier , Güntürkün Onur , Behroozi Mehdi 
Published: September 2023

AbstractFunctional magnetic resonance imaging (fMRI) in awake small animals such as pigeons or songbirds opens a new window into the neural fundaments of cognitive behavior. However, high‐field fMRI in the avian brain is challenging due to strong local magnetic field inhomogeneities caused by air cavities in the skull. A spoiled gradient‐echo fMRI sequence has already been used to map the auditory network in songbirds, but due to susceptibility artifacts only 50% of the whole brain could be recorded. Since whole‐brain fMRI coverage is vital to reveal whole‐brain networks, an MRI sequence that is less susceptible to these artifacts was required. This was recently achieved in various bird species by using a rapid acquisition with relaxation enhancement (RARE) sequence. Weak blood oxygen level‐dependent (BOLD) sensitivity, low temporal resolution, and heat caused by the long train of RF refocusing pulses are the main limits of RARE fMRI at high magnetic fields. To go beyond some of these limitations, we here describe the implementation of a two‐segmented spin‐echo echo‐planar imaging (SE‐EPI). The proposed sequence covers the whole brain of awake pigeons. The sequence was applied to investigate the auditory network in awake pigeons and assessed the relative merits of this method in comparison with the single‐shot RARE sequence. At the same imaging resolution but with a volume acquisition of 3 s versus 4 s for RARE, the two‐segmented SE‐EPI provided twice the strength of BOLD activity compared with the single‐shot RARE sequence, while the image signal‐to‐noise ratio (SNR) and in particular the temporal SNR were very similar for the two sequences. In addition, the activation patterns in two‐segmented SE‐EPI data are more symmetric and larger than single‐shot RARE results. Two‐segmented SE‐EPI represents a valid alternative to the RARE sequence in avian fMRI research since it yields more than twice the BOLD sensitivity per unit of time with much less energy deposition and better temporal resolution, particularly for event‐related experiments.
The effect of team cultural tightness and transformational leadership on employee creative behavior: A cross‐level moderated mediation model
Authors: Shi Kan , Song Xudong , Zhou Ruihua , Zhou Wei 
Published: September 2023

AbstractIn recent years, “cultural tightness–looseness” refers to the strength of social norms and tolerance for deviant behaviors perceived by individuals in society, and team cultural tightness applied at the organizational level represents the strength of team norms. According to the cultural tightness–looseness theory, this study explores the influence of team cultural tightness on employee creative behavior, as well as the moderating role of transformational leadership and the mediating role of work engagement. A questionnaire method was used to survey five enterprise organizations in China through three stages, and 288 paired questionnaires were finally obtained from leaders and employees. The results found that team cultural tightness has a significant negative effect on employee creative behavior through the mediating effect of work engagement. In other words, the more the team culture in the workplace tends to be loose, the more it stimulates employee work engagement, which in turn promotes employee creative behavior. In addition, transformational leadership played a significant positive moderating role in the model. Under the influence of transformational leadership style, the negative impact of team cultural tightness on employee work engagement and creative behavior can be mitigated. The study enriches the understanding of the influence and action mechanism of the cultural tightness–looseness theory on employee creative behavior. In future research, the action mechanism of team cultural tightness interacting with different leadership styles to influence employee creative behavior will be explored more deeply.
Spontaneous emotional regulation under experimental emotional condition: The role of working memory
Authors: Calero Alejandra Daniela , Formoso Jésica , Injoque‐Ricle Irene , Barreyro Juan Pablo , Burin Débora Inés 
Published: September 2023

AbstractThe present research studied the bidirectional effects of working memory (WM) capacity and emotional regulation; that is, the effect of WM capacity on spontaneous emotional regulation and whether the emotional valence to be regulated has a differential impact on performance in a second WM task. Participants (79) first completed a WM span task (Digit Span), then a self‐report emotional intelligence task, which was followed by randomly assigned mock Positive‐feedback, Negative‐feedback, or No‐feedback. In the Negative‐feedback and Positive‐feedback conditions, a dummy report based on participants’ responses to the Trait Meta Mood‐ 21 was shown on the screen. After that, participants completed another WM task (Running Span). An ordinary least squares multiple linear regression was used to evaluate the predictive power of WM span and experimental condition on post‐feedback test performance. The model yielded a significant effect on post‐feedback test performance for Negative‐feedback and a marginal significant effect for the interaction of this parameter with WM span. The results showed that participants in the Negative‐feedback condition performed worse than those assigned to other conditions, and individuals with a higher WM capacity were less susceptible to negative experimental stimuli.
Switching from intravenous vancomycin to oral antibiotics reduces adverse events in a retrospective cohort of outpatients with orthopedic infections
Authors: Gallagher Chanah K. , Cummins Heather , Benefield Russell J. , Certain Laura K. 
Published: September 2023

AbstractIntroductionVancomycin is frequently used for prolonged courses in treating osteoarticular infections despite a high rate of adverse drug events (ADE). The objective of this study was to evaluate the safety and effectiveness of transitioning to oral therapy compared to continuing parenteral vancomycin in patients with orthopedic infections.MethodsWe conducted a single‐center, retrospective cohort study of patients with orthopedic infections discharged on parenteral vancomycin with a planned duration of at least 4 weeks. We compared rates of ADE while on vancomycin to rates of ADE after switching to an oral regimen. As a secondary analysis, we compared unplanned hospital readmission within 60 days and treatment failure at 1 year between patients who were transitioned to oral antibiotics within 4 weeks of vancomycin initiation and those that were not.ResultsTwo hundred twenty‐eight patients met the inclusion criteria. Vancomycin was associated with significantly greater toxicity compared to oral regimens. Fifty‐one patients had an adverse event while on vancomycin (5.87 ADE per 1000 patient‐days) while 9 patients had an adverse event on oral therapy (1.49 ADE per 1000 patient‐days) (Rate difference 4.39 per 1000 patient days, 95% CI: 2.52 to 6.26 events per 1000 patient‐days). In proportional hazards analysis, transition to an oral antibiotic regimen was independently associated with a lower rate of ADE (aHR 0.12, 95% CI: 0.02–0.86). Forty‐one patients (18%) were transitioned to oral therapy within 4 weeks; these patients did not have an increased rate of unplanned readmission (12.2% vs 17.1%) or treatment failure (17.1% vs 21.9%).ConclusionsPatients transitioned to oral therapy within 4 weeks of discharge had significantly fewer adverse events and similar incidences of 1‐year treatment failure compared to patients maintained on parenteral vancomycin. Substituting oral antibiotics for parenteral vancomycin is a potential strategy to minimize vancomycin toxicity during the treatment of orthopedic infections.
4D printable shape memory polyurethane with quadruple hydrogen bonding assembly
Authors: Xu Yuanyang , Wang Yanjun , Wei Hongxiu , Dai Tiancheng , Li Zhen , Li Jiehua , Luo Feng , Tan Hong 
Published: September 2023

AbstractFour‐dimensional (4D) printing is an emerging technology for fabricating customizable tissue engineering implants. 4D printed implants with shape memory properties are expected to provide new application opportunities for minimally invasive surgery. A great challenge is to prepare the biodegradable materials with robust mechanical properties for 4D printing ink. Herein, biodegradable thermoplastic polyurethanes (TPUs) based on IPDI, PEG, PCL, and diols with UPy motifs are synthesized. The pendant UPy motifs can dimerize to form physical crosslinking by quadruple hydrogen bonding assembly, accompanying with significant improving the mechanical properties, self‐healing capability and shape memory effect. With an optimal UPy content, the PU‐U2‐25% shows robust mechanical properties and much better shape memory effect compared with the PU‐U2‐0% without UPy. Moreover, the TPUs show a facile processing at relative low temperature approximately 100 °C which avoid degradation at high processing temperature. Combined with the good processability, self‐healing capacity and shape memory effect of the PU‐U2‐25%, we primary demonstrated its 4D printing potential for various specimens. This work proposed a new strategy to design TPUs integrating the merits of linear and pendant physical crosslinking motifs to obtained excellent comprehensive properties, which would develop the 4D printable materials for applications of personalized and minimally invasive treatment.
A nonparametric control chart for monitoring count data mean
Authors: Tang Linli , Li Jun 
Published: September 2023

AbstractCount data monitoring has important applications in many fields. However, most of the existing control charts for monitoring count data are parametric. Parametric control charts can be problematic when the underlying parametric distributional assumption does not hold for the particular application. On the other hand, nonparametric control charts do not require such distributional assumptions, and are more desirable in real‐world situations where the underlying distribution cannot be easily described using a parametric distribution. In this paper, we extend the nonparametric control chart for continuous data monitoring proposed by Li to count data monitoring. To guarantee a desired in‐control performance, we further adopt the bootstrap procedure proposed by Gandy and Kvaløy to help determine the control limit of our proposed control chart. Our simulation studies and real data analysis show that the proposed control chart performs well across a variety of settings, and compares favorably with other existing nonparametric control charts for count data.
Depressed, stressed, and inflamed: C‐reactive protein linked with depression symptoms in midlife women with both childhood and current life stress
Authors: Metcalf Christina A. , Johnson Rachel L. , Duffy Korrina A. , Freeman Ellen W. , Sammel Mary D. , Epperson C. Neill 
Published: September 2023

AbstractTo determine whether the relationship between inflammatory factors and clinically significant depression symptoms is moderated by high exposure to adverse childhood experiences and current life stressors in a longitudinal community cohort of midlife women. Methods: Participants from the Penn Ovarian Ageing Study community cohort (age at baseline: M = 45.3 [SD = 3.8]) were included in analyses if they had a blood sample measuring basal inflammatory markers during at least one visit where depression symptom severity and current stressful life events were also assessed (N = 142, average number of visits per participant = 1.75 [SD = 0.92]). Approximately annually over the course of 16 years, participants self‐reported depression symptom severity using the Centre for Epidemiologic Studies Depression (CESD) Scale, provided menstrual diaries to determine menopause stage, and contributed blood samples. Residual blood samples were assayed for interleukin (IL)‐6, IL 1‐beta (IL‐1β), tumour necrosis factor alpha (TNF‐α), and high sensitivity C‐reactive protein (hsCRP). Early life stress was quantified using the Adverse Childhood Experiences questionnaire (low [0–1 experience(s)] versus high [≥ 2 experiences]). Current stressful life events were assessed using a structured interview (low [0–1 events] vs. high [≥ 2 events]). Generalised estimating equation models were used to model associations with the outcome of interest—clinically significant depression symptoms (CESD ≥16)—and risk factors: inflammatory marker levels (log transformed), adverse childhood experiences group, and current life stressors group. Covariates included menopause stage, age at study baseline, body mass index, race, and smoking status. We found a significant three‐way interaction between log hsCRP levels, adverse childhood experiences group, and current life stressors group on likelihood of experiencing clinically significant depression symptoms (OR: 4.33; 95% CI: 1.22, 15.46; p = 0.024) after adjusting for covariates. Solely for women with high adverse childhood experiences and with high current life stressors, higher hsCRP was associated with higher odds of having clinically significant depression symptoms (OR: 1.46; 95% CI 1.07, 1.98; p = 0.016). This three‐way interaction was not significant for IL‐6, IL‐1β, or TNF‐α. For women in midlife with exposure to high adverse childhood experiences and multiple current life stressors, elevated levels of CRP were uniquely associated with clinically significant depression symptoms. Early life adversity and current life stressors represent identifiable individual risk factors whose negative impact may be curtailed with inventions to target inflammation in midlife women.
Cyclin D1—Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors
Authors: Pedraza Neus , Monserrat Ma Ventura , Ferrezuelo Francisco , Torres-Rosell Jordi , Colomina Neus , Miguez-Cabello Federico , Párraga Javier Picañol , Soto David , López-Merino Esperanza , García-Vilela Celia , Esteban José A. , Egea Joaquim , Garí Eloi 
Published: September 2023

AbstractNuclear Cyclin D1 (Ccnd1) is a main regulator of cell cycle progression and cell proliferation. Interestingly, Ccnd1 moves to the cytoplasm at the onset of differentiation in neuronal precursors. However, cytoplasmic functions and targets of Ccnd1 in post-mitotic neurons are unknown. Here we identify the α4 subunit of gamma-aminobutyric acid (GABA) type A receptors (GABAARs) as an interactor and target of Ccnd1–Cdk4. Ccnd1 binds to an intracellular loop in α4 and, together with Cdk4, phosphorylates the α4 subunit at threonine 423 and serine 431. These modifications upregulate α4 surface levels, increasing the response of α4-containing GABAARs, measured in whole-cell patch-clamp recordings. In agreement with this role of Ccnd1–Cdk4 in neuronal signalling, inhibition of Cdk4 or expression of the non-phosphorylatable α4 decreases synaptic and extra-synaptic currents in the hippocampus of newborn rats. Moreover, according to α4 functions in synaptic pruning, CCND1 knockout mice display an altered pattern of dendritic spines that is rescued by the phosphomimetic α4. Overall, our findings molecularly link Ccnd1–Cdk4 to GABAARs activity in the central nervous system and highlight a novel role for this G1 cyclin in neuronal signalling.
What makes German manufacturing plants move locations?
Authors: Krenz Astrid 
Published: September 2023

AbstractIn this paper, the relocation decisions of manufacturing plants across the NUTS-3 regions of the German economy are investigated. A relocation decision concerns whether a plant (an incumbent) moves its location from one region to another over a given time period or whether it remains in the same region. This decision is distinct from a location decision (of a start-up). To analyze the relocations of plants, the rich information of the official German regional statistics as well as the official German firm statistics that are maintained by the German Federal Statistical Office and the Statistical Offices of the Federal States is exploited for the first time. Both pull and push factors that influence relocation decisions are investigated. The results reveal that, in particular, regional road infrastructure and accessibility of regions as well as the quality of the available labor force positively affect the decision to relocate a plant in the German economy. A reduction of 10% in travel time by road to reach the three nearest agglomeration centers leads to an increase in relocation probability of about 9.5% on average. Policy implications involve the need for improvement of accessibility and infrastructure as well as incentives to support human capital in order to attract businesses to move to a region.
Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma: an international retrospective study on behalf of the European paediatric Soft tissue sarcoma Study Group Imaging Committee
Authors: van Ewijk Roelof , Chatziantoniou Cyrano , Adams Madeleine , Bertolini Patrizia , Bisogno Gianni , Bouhamama Amine , Caro-Dominguez Pablo , Charon Valerie , Coma Ana , Dandis Rana , Devalck Christine , De Donno Giulia , Ferrari Andrea , Fiocco Marta , Gallego Soledad , Giraudo Chiara , Glosli Heidi , ter Horst Simone A. J. , Jenney Meriel , Klein Willemijn M. , Leemans Alexander , Leseur Julie , Mandeville Henry C. , McHugh Kieran , Merks Johannes H. M. , Minard-Colin Veronique , Moalla Salma , Morosi Carlo , Orbach Daniel , Ording Muller Lil-Sofie , Pace Erika , Di Paolo Pier Luigi , Perruccio Katia , Quaglietta Lucia , Renard Marleen , van Rijn Rick R. , Ruggiero Antonio , Sirvent Sara I. , De Luca Alberto , Schoot Reineke A. 
Published: September 2023

Abstract
Objective
To investigate the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) as a predictive imaging marker after neoadjuvant chemotherapy in patients with rhabdomyosarcoma.

Material and methods
We performed a multicenter retrospective study including pediatric, adolescent and young adult patients with rhabdomyosarcoma, Intergroup Rhabdomyosarcoma Study group III/IV, treated according to the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 or MTS2008 studies. DW-MRI was performed according to institutional protocols. We performed two-dimensional single-slice tumor delineation. Areas of necrosis or hemorrhage were delineated to be excluded in the primary analysis. Mean, median and 5th and 95th apparent diffusion coefficient (ADC) were extracted.

Results
Of 134 included patients, 82 had measurable tumor at diagnosis and response and DW-MRI scans of adequate quality and were included in the analysis. Technical heterogeneity in scan acquisition protocols and scanners was observed. Mean ADC at diagnosis was 1.1 (95% confidence interval [CI]: 1.1–1.2) (all ADC expressed in * 10−3 mm2/s), versus 1.6 (1.5–1.6) at response assessment. The 5th percentile ADC was 0.8 (0.7–0.9) at diagnosis and 1.1 (1.0–1.2) at response. Absolute change in mean ADC after neoadjuvant chemotherapy was 0.4 (0.3–0.5). Exploratory analyses for association between ADC and clinical parameters showed a significant difference in mean ADC at diagnosis for alveolar versus embryonal histology. Landmark analysis at nine weeks after the date of diagnosis showed no significant association (hazard ratio 1.3 [0.6–3.2]) between the mean ADC change and event-free survival.

Conclusion
A significant change in the 5th percentile and the mean ADC after chemotherapy was observed. Strong heterogeneity was identified in DW-MRI acquisition protocols between centers and in individual patients.

Graphical Abstract
Impact of residual tumor cells in the stem cell collection on multiple myeloma patients receiving autologous stem cell transplantation
Authors: Xu Jingyu , Yan Wenqiang , Fan Huishou , Liu Jiahui , Li Lingna , Du Chenxing , Deng Shuhui , Sui Weiwei , Xu Yan , Qiu Lugui , An Gang 
Published: September 2023

AbstractAutologous stem cell transplantation (ASCT) is the standard therapy for patients with transplant-eligible multiple myeloma (TEMM). However, the ideal depth of response required before ASCT and the impact of residual tumor cells in the stem cell collection (SCC) on survival remains unclear. Here we collected data of 89 patients with TEMM undergoing ASCT and analyzed the minimal residual disease of SCC (cMRD) and bone marrow (BM) (mMRD) before transplantation. Before ASCT, 31.5% and 76.4% of patients achieved MRD negativity in BM and SCC, respectively. Tumor cells were less in SCC samples than that in BM samples. Neoplastic cells in SCC could be observed in patients with different responses after induction therapy, and there were no significant differences in the percentage and level of cMRD among these subgroups (P > 0.05). No correlation was found between the cMRD status and the response patients achieved after ASCT (P > 0.05). The median follow-up was 26.8 months. mMRD negativity before ASCT was associated with longer PFS (55.9 vs. 27.1 months; P = 0.009) but not OS (not reached vs. 58.9 months; P = 0.115). Patients with different cMRD statuses before ASCT experienced similar PFS (40.5 vs. 76.4 months for negativity vs. positivity; P = 0.685) and OS (not reached vs. 58.8 months for negativity vs. positivity; P = 0.889). These results suggested that detectable cMRD does not significantly predict the inferior post-ASCT response or shorter survival, and patients are eligible to undergo ASCT upon achieving partial response.
Considerations on surgical strategies and associated risk profiles for endoscopic tumor biopsies within the third ventricle and periaqueductal region
Authors: Teping Fritz , Oertel Joachim 
Published: September 2023

Abstract
Introduction
Neuroendoscopic techniques have proven to be a successful and minimally-invasive technique for tumor biopsies within the third ventricle in pediatric patients. However, a comprehensive assessment of associated surgical strategies, techniques, and morbidity is essential to optimize patient outcomes.

Methods
This retrospective study analyzed full endoscopic tumor biopsies in pediatric patients with tumors in the third ventricle and periaqueductal region. Data from 1995 to 2022 were collected from medical records, imaging, and intraoperative video documentation.

Results
In this study, 16 shear endoscopic tumor biopsies were performed using the transventricular transforaminal approach. Tumors were located in the anterior or mid part of the third ventricle (50%) or in the periaqueductal and pineal recess region (50%). Preoperative hydrocephalus was seen in 81.25%. Tumor biopsies were harvested successfully in all cases. Simultaneous ETV was performed in 12 (75%) cases and additional septostomy in 3 (18.75%). Significant intraoperative bleeding occurred in 3 cases (18.75%). All bleeding situations could be successfully managed with continuous irrigation. Histopathology revealed astrocytoma as the predominant diagnosis (75%). No new neurologic deficits were observed, except for one case of transient oculomotor nerve paralysis after ETV. Hydrocephalus persisted in 18.6% of all cases with the need of urgent ventriculoperitoneal shunting in two patients.

Conclusion
In conclusion, neuroendoscopy emerges as an effective technique for tumor biopsies within the third ventricle in pediatric patients, offering the added advantage of simultaneous treatment of obstructive hydrocephalus. However, it is essential to acknowledge the specific intra- and postoperative risks associated with various surgical strategies. The safe management and achievement of favorable clinical results demand extensive experience and expertise.