bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interannual variation of summer sea surface temperature in the Amundsen Sea, Antarctica
Authors: Yu Lu-Sha , He Hailun , Leng Hengling , Liu Hailong , Lin Pengfei 
Published: March 2023

This paper investigates the interannual variability of January sea surface temperature (SST) in the Amundsen Sea (AS) during the period 1982–2022. SST in the Pine Island Bay (PIB) is found to exhibit the most significant interannual variation, with a standard deviation up to 0.6°. Composite analysis indicates that, in warmer years, the January SST at PIB is approximately 1° higher on average than that in cooler years, and its variation in warmer (cooler) years corresponds to lower (higher) sea ice concentration (SIC) and more (less) surface heat flux; the latter factor is primarily influenced by the albedo of SIC. Further analysis suggests that variability in January SIC is largely dominated by northward sea ice motion during the previous November (r = −0.82), which is consistent with the presence of a contemporaneous northerly 10 m wind anomaly trigged by the Amundsen Sea Low (ASL). The ASL-associated northerly wind anomaly drives northward sea ice motion, reduces SIC, and thus increases the downward heat flux that ultimately results in warmer SST, and vice versa. This study identifies the possible mechanism of anomalous January SST in the PIB, which could provide an important clue for seasonal forecasts of summer SST in the AS.
Development and performance of a clear aligner film loaded with sustained release hydrogen peroxide gel
Authors: Cheng Yuxun , Fang Shishu , Liu Xulin , Li Xin , Song Zhixin , Ma Yanning , Jin Zuolin 
Published: March 2023

Introduction: Clear aligner treatment (CAT) has become popular over recent years because it is both comfortable and aesthetically acceptable. However, most of patients undergoing orthodontic treatment request dental bleaching. A safe and controlled bleaching treatment at the same time as the clear aligner treatment can save time and improve patient satisfaction with the outcome of the treatment.Aim: This study was aimed to develop a thermoforming film loaded with hydrogen peroxide as a clear aligner and detect its efficiency on teeth blenching and its influence on shear bonding strength for attachment.Methods: The thermoforming film loaded with sodium alginate-dopamine/Mesoporous silica nanoparticles compound gel was immersed in 6 wt% hydrogen peroxide solution and the hydrogen peroxide was loaded into mesoporous silica nanoparticle channels by capillary action. Then, a thermoforming film loaded with sustained-release hydrogen peroxide gel was made. Six dentition models were prepared with 90 isolated human premolars and divided into the experiment group, the condition control group and the blank control group, respectively. Then, the experiment group wore the clear aligner made by the thermoforming film loaded with hydrogen peroxide for 40 days; the conditional control group wore the clear aligner made by the ordinary thermoforming film for 40 days; and the blank control group wore no clear aligner. The aligners were updated every 10 days and the color of teeth was measured every 10 days. Tooth color should be determined by specific parameters (L, a* and b*). What’s more, in order to determine the influence of the thermoforming film loaded with sustained-release hydrogen peroxide gel on shear bonding strength for attachment. The shear bonding strength of attachment of isolated premolars were measured.Results: Isolated premolars treated by bleaching experiments showed an increase in L value (ΔL = 7.76 ± 0.64) and a decrease in both a* (Δa = −0.82 ± 0.12) and b* (Δb = −3.10 ± 0.21) values. However, the isolated premolars in conditional control group and blank control group exhibited that an decrease in L value (ΔLCCG = −0.91 ± 0.24; ΔLBCG = −0.86 ± 0.15)and a increase in both a* (ΔaCCG = 0.19 ± 0.05; ΔaBCG = 0.18 ± 0.04) and b* (ΔbCCG = 0.43 ± 0.11; ΔbBCG = 0.31 ± 0.10) value. While the shear bonding strength for attachment after bleaching was 22.78 ± 2.28 MPa, which had no significant change compared with the shear bonding strength for attachment without bleaching experiment (22.21 ± 2.77 MPa) (p &gt; 0.05). Conclusion: A thermoforming film featuring the sustained release of hydrogen peroxide had a good bleaching effect on isolated teeth and had no significant influence on the shear bonding strength for attachment.
A descriptive study of the clinical impacts on COVID-19 survivors using telemonitoring (The TeleCOVID Study)
Authors: Chow Josephine Sau Fan , D’Souza Annamarie , Ford Megan , Marshall Sonia , San Miguel Susana , Parameswaran Ahilan , Parsons Mark , Ramirez Jacqueline , Teramayi Rumbidzai , Maurya Nutan 
Published: March 2023

BackgroundThere is increasing evidence that COVID-19 survivors are at increased risk of experiencing a wide range of cardiovascular complications post infection; however, there are no validated models or clear guidelines for remotely monitoring the cardiac health of COVID-19 survivors.ObjectiveThis study aims to test a virtual, in-home healthcare monitoring model of care for detection of clinical symptoms and impacts on COVID-19 survivors. It also aims to demonstrate system usability and feasibility.MethodsThis open label, prospective, descriptive study was conducted in South Western Sydney. Included in the study were patients admitted to the hospital with the diagnosis of COVID-19 between June 2021 and November 2021. Eligible participants after consent were provided with a pulse oximeter to measure oxygen saturation and a S-Patch EX to monitor their electrocardiogram (ECG) for a duration of 3 months. Data was transmitted in real-time to a mobile phone via Bluetooth technology and results were sent to the study team via a cloud-based platform. All the data was reviewed in a timely manner by the investigator team, for post COVID-19 related symptoms, such as reduction in oxygen saturation and arrhythmia.Outcome measureThis study was designed for feasibility in real clinical setting implementation, enabling the study team to develop and utilise a virtual, in-home healthcare monitoring model of care to detect post COVID-19 clinical symptoms and impacts on COVID-19 survivors.ResultsDuring the study period, 23 patients provided consent for participation. Out of which 19 patients commenced monitoring. Sixteen patients with 81 (73.6%) valid tests were included in the analysis and amongst them seven patients were detected by artificial intelligence to have cardiac arrhythmias but not clinically symptomatic. The patients with arrhythmias had a higher occurrence of supraventricular ectopy, and most of them took at least 2 tests before detection. Notably, patients with arrhythmia had significantly more tests than those without [t-test, t (13) = 2.29, p &lt; 0.05].ConclusionsPreliminary observations have identified cardiac arrhythmias on prolonged cardiac monitoring in 7 out of the first 16 participants who completed their 3 months follow-up. This has allowed early escalation to their treating doctors for further investigations and early interventions.
Model transfer from 2D to 3D study for boxing pose estimation
Authors: Lin Jianchu , Xie Xiaolong , Wu Wangping , Xu Shengpeng , Liu Chunyan , Hudoyberdi Toshboev , Chen Xiaobing 
Published: March 2023

IntroductionBoxing as a sport is growing on Chinese campuses, resulting in a coaching shortage. The human pose estimation technology can be employed to estimate boxing poses and teach interns to relieve the shortage. Currently, 3D cameras can provide more depth information than 2D cameras. It can potentially improve the estimation. However, the input channels are inconsistent between 2D and 3D images, and there is a lack of detailed analysis about the key point location, which indicates the network design for improving the human pose estimation technology.MethodTherefore, a model transfer with channel patching was implemented to solve the problems of channel inconsistency. The differences between the key points were analyzed. Three popular and highly structured 2D models of OpenPose (OP), stacked Hourglass (HG), and High Resolution (HR) networks were employed. Ways of reusing RGB channels were investigated to fill up the depth channel. Then, their performances were investigated to find out the limitations of each network structure.Results and discussionThe results show that model transfer learning by the mean way of RGB channels patching the lacking channel can improve the average accuracies of pose key points from 1 to 20% than without transfer. 3D accuracies are 0.3 to 0.5% higher than 2D baselines. The stacked structure of the network shows better on hip and knee points than the parallel structure, although the parallel design shows much better on the residue points. As a result, the model transfer can practically fulfill boxing pose estimation from 2D to 3D.
Comparison of micro-radiofrequency therapy and tolterodine for the treatment of newly diagnosed overactive bladder: A retrospective cohort study
Authors: Tang Min , Liu Jin , Zhao Chesong , Wang Chengming , Zhang Qian , Du Mulong , Meng Xiaoxin , Li Pu 
Published: March 2023

PurposeThis study aimed to retrospectively compare the efficacy and safety of micro-radiofrequency (RF) therapy through the urethra vs. oral tolterodine tartrate in the treatment of newly diagnosed overactive bladder (OAB).Materials and methodsIn this study, 46 patients who were newly diagnosed with moderate-to-severe OAB were included; 23 of them underwent the micro-RF treatment procedure, and the other 23 patients took tolterodine. Bladder diaries were recorded 3 days before treatment and during the follow-up period on 1, 3, and 7 weeks after micro-RF therapy or oral tolterodine. Micturition parameters including daily voiding times, daily urge urinary incontinence (UI) episodes, daily urgency episodes, mean volume per micturition, post-void residual volume (PVR), maximum urine flow rate (Qmax), overactive bladder symptom score (OABSS), and quality of life (QoL) score were analyzed.ResultsAll 46 patients underwent either micro-RF or oral tolterodine treatment, as well as a complete follow-up. The incidence of adverse events in the micro-RF group was 8.7% (2/23), and that in the tolterodine group was 43.5% (10/23). The following two adverse events happened in the micro-RF group: an injury to the urethra during catheterization in a man and a urinary tract infection in a woman, both of which were relieved or disappeared after day 3. The adverse effects in the tolterodine group were mainly dry mouth (4/23), dysuria (5/23), and constipation (8/23), but none of the patients withdrew from the drug therapy. Compared to pre-therapy, all parameters of both groups, including daily voiding times, daily urgency episodes, mean volume per micturition, OABSS, and QoL score, demonstrated significant improvements during follow-up in 7 weeks after therapy, except for daily UI episodes in the tolterodine group, while the above parameters showed bigger improvements in the micro-RF group than in the tolterodine group. Besides, the general treatment efficacy of micro-RF was 73.9% (17/23), which was significantly better than tolterodine (10/23, 43.5%), and the difference was 30.4% [95% CI: 3.4–57.5%, p = 0.036].ConclusionIn this retrospective study, we found that micro-RF therapy is safe and more effective than oral tolterodine for newly diagnosed moderate-to-severe OAB in a short-term follow-up. Stronger evidence would be provided through a well-designed, prospective, randomized controlled trial.
Haploidentical vs. HLA-matched donor hematopoietic stem-cell transplantation for pediatric patients with acute lymphoblastic leukemia in second remission: A collaborative retrospective study of the Spanish Group for Bone Marrow Transplantation in Children (GETMON/GETH) and the Spanish Childhood Relapsed ALL Board (ReALLNet)
Authors: Moreno Celia , Ramos-Elbal Eduardo , Velasco Pablo , Aguilar Yurena , Gonzáález Martínez Berta , Fuentes Carolina , Molinos Águeda , Guerra-García Pilar , Palomo Pilar , Verdu Jaime , Adán Pedroso Rosa María , Vagace José Manuel , López-Duarte Mónica , Regueiro Alexandra , Tasso María , Dapena José Luis , Salinas José Antonio , Navarro Samuel , Bautista Francisco , Lassaletta Álvaro , Lendínez Francisco , Rives Susana , Pascual Antonia , Rodríguez Antonia , Pérez-Hurtado José María , Fernández José María , Pérez-Martínez Antonio , González-Vicent Marta , Díaz de Heredia Cristina , Fuster José Luis 
Published: March 2023

IntroductionStudies addressing the role of haploidentical as alternative to HLA-matched donors for stem cell transplantation (SCT) often include patients with diverse hematological malignancies in different remission statuses.MethodsWe compared outcomes of children with acute lymphoblastic leukemia (ALL) undergoing SCT in second complete remission (CR2) from haploidentical (n = 25) versus HLA-matched donor (n = 51).ResultsPatients were equally distributed across both groups according to age, immunophenotype, time to and site of relapse, relapse risk-group allocation, and minimal residual disease (MRD) before SCT. Incidence of graft failure, acute graft versus host disease (GVHD), and other early complications did not differ between both groups. We found no differences in overall survival (58.7% versus 59.5%; p = .8), leukemia free survival (LFS) (48% versus 36.4%; p = .5), event free survival (40% versus 34.4%; p = .69), cumulative incidence (CI) of subsequent relapse (28% versus 40.9%; p = .69), treatment related mortality (24% versus 23.6%; p = .83), CI of cGVHD (4.5% versus 18.7%; p = .2), and chronic GVHD-free and leukemia-free survival (44% versus 26.3%; p = .3) after haploidentical donor SCT. Chronic GVHD (HR = 0.09; p=.02) had protective impact, and MRD ≥ 0.01% before SCT (HR = 2.59; p=.01) had unfavorable impact on LFS.DiscussionThese results support the role of haploidentical donor SCT in children with ALL in CR2.
The difference in mean arterial pressure induced by remimazolam compared to etomidate in the presence of fentanyl at tracheal intubation: A randomized controlled trial
Authors: Huang Xiaofang , Cao Huiyu , Zhang Cuiwen , Lan Hongmeng , Gong Xiaofang , Li Ruijie , Lin Yan , Xu Bing , Chen Huihe , Guan Xuehai 
Published: March 2023

Background: Combined use of hypnotic and opioids during anesthesia inductions decreases blood pressure. Post-induction hypotension (PIHO) is the most common side effect of anesthesia induction. We aimed to compare the difference in mean arterial pressure (MAP) induced by remimazolam with that induced by etomidate in the presence of fentanyl at tracheal intubation.Methods: We assessed 138 adult patients with American Society of Anesthesiologists physical status I–II who underwent elective urological surgery. Patients were randomly allocated to receive either remimazolam or etomidate as alterative hypnotic in the presence of fentanyl during anesthesia induction. Comparable BIS values were achieved in both groups. The primary outcome was the difference in the MAP at tracheal intubation. The secondary outcomes included the characteristics of anesthesia, surgery, and adverse effects.Results: The MAP was higher in the etomidate group than in the remimazolam group at tracheal intubation (108 [22] mmHg vs. 83 [16] mmHg; mean difference, −26; 95% confidence interval [CI], −33 to −19; p &lt; 0.0001). Heart rate was significantly higher in the etomidate group than in the remimazolam group at tracheal intubation. The patients’ condition warranted the administration of ephedrine more frequently in the remimazolam group (22%) than in the etomidate group (5%) (p = 0.0042) during anesthesia induction. The remimazolam group had a lower incidence of hypertension (0% vs. 9%, p = 0.0133), myoclonus (0% vs. 47%, p &lt; 0.001), and tachycardia (16% vs. 35%, p = 0.0148), and a higher incidence of PIHO (42% vs. 5%, p = 0.001) than the etomidate group during anesthesia induction.Conclusion: Remimazolam was associated with lower MAP and lower heart rate compared to etomidate in the presence of fentanyl at tracheal intubation. Patients in the remimazolam group had a higher incidence of PIHO, and their condition warranted the administration of ephedrine more frequently than in the etomidate group during anesthesia induction.
Study on the ground impact vibration intensity model of high energy warhead explosion
Authors: Wang Liangquan , Kong Deren , Shang Fei 
Published: March 2023

Introduction: In the warhead explosion process, the ground impact vibration intensity will directly affect the target buildings and instruments safety, and it is also of great significance to accurately evaluate the ammunition explosion damage power.Methods: In this study, the finite element numerical simulation method was used to analyze the explosion shock wave pressure and ground shock vibration velocity of TNT explosive with a mass of 100 kg∼1000 kg, and the ground transmission medium of sandy soil, C35 and C140 concrete, and the shock wave pressure and ground shock vibration velocity propagation and distribution law was clarified. Based on the explosion similarity law and dimensional analysis method, a ground impact vibration velocity theoretical calculation model with clear physical significance is established by introducing the property ground propagation medium parameters, taking into account the factors affecting the ground impact vibration velocity.Results: The model calculation accuracy is verified by the measured data. The verification results show that the model calculation accuracy is higher than 91.8%, which improves the calculation accuracy of the explosion site ground impact vibration velocity.Discussion: This research provides more accurate and scientific theory and data support for the ammunition explosion damage power evaluation, and provides a reference for the shock and vibration resistance performance design of instruments, equipment and buildings. It has strong engineering application value.
Characterization of MdMYB68, a suberin master regulator in russeted apples
Authors: Xu Xuan , Guerriero Gea , Domergue Frederic , Beine-Golovchuk Olga , Cocco Emmanuelle , Berni Roberto , Sergeant Kjell , Hausman Jean-Francois , Legay Sylvain 
Published: March 2023

IntroductionApple russeting is mainly due to the accumulation of suberin in the cell wall in response to defects and damages in the cuticle layer. Over the last decades, massive efforts have been done to better understand the complex interplay between pathways involved in the suberization process in model plants. However, the regulation mechanisms which orchestrate this complex process are still under investigation. Our previous studies highlighted a number of transcription factor candidates from the Myeloblastosis (MYB) transcription factor family which might regulate suberization in russeted or suberized apple fruit skin. Among these, we identified MdMYB68, which was co-expressed with number of well-known key suberin biosynthesis genes.MethodTo validate the MdMYB68 function, we conducted an heterologous transient expression in Nicotiana benthamiana combined with whole gene expression profiling analysis (RNA-Seq), quantification of lipids and cell wall monosaccharides, and microscopy.ResultsMdMYB68 overexpression is able to trigger the expression of the whole suberin biosynthesis pathway. The lipid content analysis confirmed that MdMYB68 regulates the deposition of suberin in cell walls. Furthermore, we also investigated the alteration of the non-lipid cell wall components and showed that MdMYB68 triggers a massive modification of hemicelluloses and pectins. These results were finally supported by the microscopy.DiscussionOnce again, we demonstrated that the heterologous transient expression in N. benthamiana coupled with RNA-seq is a powerful and efficient tool to investigate the function of suberin related transcription factors. Here, we suggest MdMYB68 as a new regulator of the aliphatic and aromatic suberin deposition in apple fruit, and further describe, for the first time, rearrangements occurring in the carbohydrate cell wall matrix, preparing this suberin deposition.
Benefits of personal music listening for family caregivers of critically ill patients during the post-COVID era
Authors: Yoo Ga Eul , Na Sungwon , Kim Soo Ji , Kim Jeongmin 
Published: March 2023

ObjectiveThis descriptive study surveyed family caregivers of patients in intensive care units (ICUs) during the COVID-19 pandemic to examine the impact of musical listening on their psychological well-being.MethodThe data collected in this study compared with collected from similar research conducted before the COVID-19 pandemic in 2017. The previous study had 195 participants, and the current study had 92. To measure the participants’ psychological well-being, the Korean version of the Center for Epidemiologic Studies Depression Scale and the World Health Organization Quality of Life Scale were administered. An investigator-constructed questionnaire was also used to collect information related to participants’ engagement in music activities including music listening in their everyday lives and their perceptions of music’s benefits.ResultsA two-way ANOVA showed significant effects for time (e.g., before vs. during COVID-19) and involvement in personal music listening (yes vs. no) on current emotional state, with family caregivers reporting significantly greater negative emotions during COVID-19 than before and personal music listening having a positive effect on perceived emotions. For quality of life there was no significant time effect, while the listening effect was statistically significant, indicating a significantly higher quality of life in the group who engaged in music listening in their everyday lives compared to the group who did not. There were no significant time or listening effects for perceived level of depression.ConclusionGiven the COVID-19 situation and the need to transition to a post-pandemic era, this study suggests that music listening can be an effective option for family caregivers to implement as a resource for attenuating emotional distress and enhancing self-care.
Correlating electroconvulsive therapy response to electroencephalographic markers: Study protocol
Authors: Subramanian Subha , Labonte Alyssa K. , Nguyen Thomas , Luong Anhthi H. , Hyche Orlandrea , Smith S. Kendall , Hogan R. Edward , Farber Nuri B. , Palanca Ben Julian A. , Kafashan MohammadMehdi ,   CET-REM Study Group
Published: March 2023

IntroductionElectroconvulsive therapy (ECT) is an effective intervention for patients with major depressive disorder (MDD). Despite longstanding use, the underlying mechanisms of ECT are unknown, and there are no objective prognostic biomarkers that are routinely used for ECT response. Two electroencephalographic (EEG) markers, sleep slow waves and sleep spindles, could address these needs. Both sleep microstructure EEG markers are associated with synaptic plasticity, implicated in memory consolidation, and have reduced expression in depressed individuals. We hypothesize that ECT alleviates depression through enhanced expression of sleep slow waves and sleep spindles, thereby facilitating synaptic reconfiguration in pathologic neural circuits.MethodsCorrelating ECT Response to EEG Markers (CET-REM) is a single-center, prospective, observational investigation. Wireless wearable headbands with dry EEG electrodes will be utilized for at-home unattended sleep studies to allow calculation of quantitative measures of sleep slow waves (EEG SWA, 0.5–4 Hz power) and sleep spindles (density in number/minute). High-density EEG data will be acquired during ECT to quantify seizure markers.DiscussionThis innovative study focuses on the longitudinal relationships of sleep microstructure and ECT seizure markers over the treatment course. We anticipate that the results from this study will improve our understanding of ECT.