bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Model Pembelajaran Think Talk Write Menggunakan Media Power Point untuk Meningkatkan Komunikasi Siswa
Authors: Yuniati Fatma , Haryanto Sri , Firdaus Firdaus 
Published: March 2023

Abstract: This study aims to determine how the level of communication skills is seen from the group of students' initial understanding and the level of students' final understanding. Is there a difference, and how much is the increase in students' communication results after applying the Think Talk Write model using PowerPoint media? This type of quantitative research with quasi-experiments utilizing a control group design. The population in the study was class VIII A as the control class and class VIII B as the experimental class, each of which consisted of 20 students. Data collection was obtained using the method of documentation, testing, and communication observation. The results showed that the application of the TTW Learning Model (Think Talk Write) using PowerPoint media to improve students' communication skills for the initial level of student communication results was included in the low category, with an average of 48.70 for the control class and 48.70 for the experimental type. The story of student communication is obtained from the pre-test scores. The students' final communication results increased after treatment, averaging 72.75 for the control class and 90.30 for the experimental type. The students' last communication level was obtained from the post-test scores. In conclusion, there are differences in improving communication results using the Think Talk Write (TTW) learning model using PowerPoint (PPT) media to improve student communication.

Keywords: Student Communication, PowerPoint, Think Talk Write
Study of the effectiveness of antimicrobial dressings with chlorhexidine bigluconate in the prevention of catheter-related blood-stream infections in pediatric intensive care units
Authors: Dmytriev Dmytro , Nazarchuk Oleksandr , Babina Yuliana 
Published: March 2023

Introduction. Nosocomial infections are risk factors associated with in-hospital mortality. Among other factors, these infections are strongly associated with invasive devices. In pediatric patients, a central venous catheter (CVC) is one of the most common causes of catheter-related bloodstream infection (CRBSI).
Background. To investigate the effectiveness of antimicrobial chlorhexidine dressings compared with standard dressings in the prevention of central venous catheter-related bloodstream infections.
Methods. 20 children who were treated in the intensive care unit were randomly divided into two groups of 10: a group that used chlorhexidine dressings and a group that used standard dressings (comparison group). Patient care was carried out in accordance with asepsis and antisepsis rule. The primary outcomes were a comparative study of microbiological researches of peripheral blood blood culture and catheter blood sample. But the final results were cultures from the tip of the catheter (at least 5 cm) after removal of the catheter in case of clinical symptoms of KAIK or in case of planned removal of the catheter due to the lack of its further need.
Results. Catheter colonization occurred in 3 patients in the control group (3 %) and in 2 patients in the chlorhexidine dressing group (2 %). Catheter-related bloodstream infections occurred in 3 patients in the control group (3%), and in patients in the chlorhexidine group, no microorganisms were isolated by microbiological examination of the implantation sites (0 %). Although more patients in the comparison group had catheter-related bloodstream infections, the difference in infection rates between the two groups was insignificant (P = 0.07).
Conclusions. The use of chlorhexidine-impregnated dressings reduced the incidence of catheter-related bloodstream infections, contamination, colonization, and local catheter infection in the pediatric intensive care unit, but there was no significant difference compared with the use of standard dressings. This study needs further study in pediatric patients.
Quercetin as an effective antioxidant against superoxide radical
Authors: Cizmarova Beata , Hubkova Beata , Birkova Anna 
Published: March 2023

Background: Quercetin is considered one of the most studied flavonols widely found in fruits and vegetables. Food preparation and storage affect the level of quercetin in food, as these processes can cause a partial or complete reduction in flavonol levels. Quercetin, as a bioactive compound, has beneficial effects on the human body and with various diseases due to its potent antioxidant properties. Quercetin is a scavenger of free radicals and exerts its effects in various body fluids (e.g., saliva, synovial fluid, blood). Because of this, it is essential to know the effect of pH on its antioxidant properties.Objective: This study aims to determine the antioxidant capacity of quercetin against superoxide radicals depending on pH using a spectroscopic method.Methods: The antioxidant properties of quercetin in the concentration range from 5 to 50 μg/ml against superoxide radicals were measured at pH values of 6.5 to 8. Superoxide radicals were generated in the photooxidation reaction of methionine with riboflavin. Inhibition of superoxide radicals by quercetin was detected spectrophotometrically in reaction with NTB.Results: Quercetin is an effective superoxide radical scavenger with the highest antioxidant capacity observed at a slightly acidic pH of 6.5. The antioxidant activity of quercetin increased with increasing concentration; effective antioxidant capacity of quercetin was in the experiment at a concentration above 30 µg/ml.Conclusion: Quercetin is a widely occurring flavonoid with many beneficial effects on the human body related to its antioxidant properties. Quercetin is an effective scavenger of superoxide radicals. Its correct dosage, processing, and storage, which significantly affect the antioxidant properties of quercetin, have a considerable impact on the effects of quercetin in the prevention and treatment of diseases. Since pH significantly affects biochemical processes in living organisms, our results could contribute to expanding information on the antioxidant properties of quercetin as a rich natural source of medicinal substances, depending on pH.Keywords:quercetin, antioxidant, superoxide radical, spectrophotometry
Periarticular muscle status affects in vivo tibio-femoral joint loads after total knee arthroplasty
Authors: Winkler Tobias , Bell Louisa , Bender Alwina , Trepczynski Adam , Duda Georg N. , Baur Alexander J. D. , Damm Philipp 
Published: March 2023

Background: Total knee arthroplasty (TKA) is a highly effective treatment for severe knee osteoarthritis that is increasingly performed in younger, more active patients. As postoperative muscular impairments may negatively affect surgical outcomes and implant longevity, functional muscle recovery gains increasing importance in meeting future patient demands. This study aimed to assess the status of periarticular muscles in the long-term follow-up after TKA and to evaluate its impact on in vivo tibio-femoral joint loads.Methods: A case series was created, with eight patients with knee osteoarthritis. All subjects received an instrumented knee implant in unilateral TKA. Native computed tomography scans, acquired pre and postoperatively, were used to evaluate distal muscle volumes and fatty infiltration. In vivo tibio-femoral joint loads were measured telemetrically during standing, walking, stair climbing and chair rising and were correlated to muscle status.Results: Postoperatively a reduction in fatty infiltration across all periarticular muscles was pronounced. High average peak loads acted in the tibio-femoral joint ranging from 264% during stand-to-sit activities up to 341% body weight (BW) during stair descent. Fatty infiltration of the m. quadriceps femoris and hamstrings were associated with increased tibio-femoral joint contact forces during walking (r = 0.542; 0.412 and 0.766).Conclusion: The findings suggest that a fatty infiltration of periarticular muscles may lead to increased tibio-femoral joint contact forces. However, we only observed weak correlations between these parameters. Improvements in functional mobility and the restoration of a pain-free joint likely explain the observed postoperative reductions in fatty infiltration. Perioperative rehabilitation approaches targeting residual impairments in muscle quality could, contribute to reduced tibio-femoral joint loads and improved long-term outcomes of TKA. However, it has to be pointed out that the study included a small number of patients, which may limit its validity.
Time-restricted feeding’s effect on overweight and obese patients with chronic kidney disease stages 3-4: A prospective non-randomized control pilot study
Authors: Lao Bei-ni , Luo Jiang-hong , Xu Xue-yi , Fu Li-zhe , Tang Fang , Ouyang Wen-wei , Xu Xin-zhu , Wei Meng-ting , Xiao Bing-jie , Chen Lin-yi , Wu Yi-fan , Liu Xu-sheng 
Published: March 2023

BackgroundTime-restricted feeding (TRF) has become a popular weight loss method in recent years. It is widely used in the nutritional treatment of normal obese people and obese people with chronic diseases such as diabetes mellitus and hypertension, and has shown many benefits. However, most TRF studies have excluded chronic kidney disease (CKD) patients, resulting in a lack of sufficient evidence-based practice for the efficacy and safety of TRF therapy for CKD. Therefore, we explore the efficacy and safety of TRF in overweight and obese patients with moderate-to-severe stage CKD through this pilot study, and observe patient compliance to assess the feasibility of the therapy.MethodsThis is a prospective, non-randomized controlled short-term clinical trial. We recruited overweight and obese patients with CKD stages 3-4 from an outpatient clinic and assigned them to either a TRF group or a control diet (CD) group according to their preferences. Changes in renal function, other biochemical data, anthropometric parameters, gut microbiota, and adverse events were measured before the intervention and after 12 weeks.ResultsThe change in estimated glomerular filtration rate (eGFR) before and after intervention in the TRF group (Δ = 3.1 ± 5.3 ml/min/1.73m2) showed significant improvement compared with the CD group (Δ = -0.8 ± 4.4 ml/min/1.73m2). Furthermore, the TRF group had a significant decrease in uric acid (Δ = -70.8 ± 124.2 μmol/L), but an increase in total protein (Δ = 1.7 ± 2.5 g/L), while the changes were inconsistent for inflammatory factors. In addition, the TRF group showed a significant decrease in body weight (Δ = -2.8 ± 2.9 kg) compared to the CD group, and body composition indicated the same decrease in body fat mass, fat free mass and body water. Additionally, TRF shifted the gut microbiota in a positive direction.ConclusionPreliminary studies suggest that overweight and obese patients with moderate-to-severe CKD with weight loss needs, and who were under strict medical supervision by healthcare professionals, performed TRF with good compliance. They did so without apparent adverse events, and showed efficacy in protecting renal function. These results may be due to changes in body composition and alterations in gut microbiota.
Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors
Authors: Gil Joan , Marques-Pamies Montserrat , Valassi Elena , Serra Guillermo , Salinas Isabel , Xifra Gemma , Casano-Sancho Paula , Carrato Cristina , Biagetti Betina , Sesmilo Gemma , Marcos-Ruiz Jennifer , Rodriguez-Lloveras Helena , Rueda-Pujol Anna , Aulinas Anna , Blanco Alberto , Hostalot Cristina , Simó-Servat Andreu , Muñoz Fernando , Rico Marta , Ibáñez-Domínguez Javier , Cordero Esteban , Webb Susan M. , Jordà Mireia , Puig-Domingo Manel 
Published: March 2023

IntroductionDifferent medical therapies have been developed for pituitary adenomas. However, Non-Functioning Pituitary Neuroendocrine Tumors (NF-PitNET) have shown little response to them. Furthermore, epithelial-mesenchymal transition (EMT) has been linked to resistance to medical treatment in a significant number of tumors, including pituitary adenomas.MethodsWe aimed to evaluate the expression of EMT-related markers in 72 NF-PitNET and 16 non-tumoral pituitaries. To further explore the potential usefulness of medical treatment for NF-PitNET we assessed the expression of somatostatin receptors and dopamine-associated genes.ResultsWe found that SNAI1, SNAI2, Vimentin, KLK10, PEBP1, Ki-67 and SSTR2 were associated with invasive NF-PitNET. Furthermore, we found that the EMT phenomenon was more common in NF-PitNET than in GH-secreting pituitary tumors. Interestingly, PEBP1 was overexpressed in recurrent NF-PitNET, and could predict growth recurrence with 100% sensitivity but only 43% specificity. In parallel with previously reported studies, SSTR3 is highly expressed in our NF-PitNET cohort. However, SSTR3 expression is highly heterogeneous among the different histological variants of NF-PitNET with very low levels in silent corticotroph adenomas.ConclusionNF-PitNET showed an enhanced EMT phenomenon. SSTR3 targeting could be a good therapeutic candidate in NF-PitNET except for silent corticotroph adenomas, which express very low levels of this receptor. In addition, PEBP1 could be an informative biomarker of tumor regrowth, useful for predictive medicine in NF-PitNET.
HIDEA syndrome: A new case report highlighting similarities with ROHHAD syndrome
Authors: Harvengt J. , Lumaka A. , Fasquelle C. , Caberg J. H. , Mastouri M. , Janssen A. , Palmeira L. , Bours V. 
Published: March 2023

Context: ROHHAD syndrome presents a significant resemblance to HIDEA syndrome. The latter is caused by biallelic loss-of-function variants in the P4HTM gene and encompasses hypotonia, intellectual disabilities, eye abnormalities, hypoventilation, and dysautonomia. We report the first patient identified with HIDEA syndrome from our ROHHAD cohort.Clinical case: Our patient was a 21-month-old girl who had a history of severe respiratory infections requiring intensive care, hypotonia, abnormal eye movements, and rapid weight gain. Polysomnography identified severe central hypoventilation. During her follow-up, a significant psychomotor delay and the absence of language were gradually observed. The prolactin levels were initially increased. Hypothermia was reported at 4 years. Exome sequencing identified a new homozygous truncating P4HTM variant.Discussion: Our patient met the diagnosis criteria for ROHHAD, which included rapid weight gain, central hypoventilation appearing after 1.5 years of age, hyperprolactinemia suggesting hypothalamic dysfunction, and autonomic dysfunction manifesting as strabismus and hypothermia. However, she also presented with severe neurodevelopmental delay, which is not a classic feature of ROHHAD syndrome. HIDEA syndrome presents similarities with ROHHAD, including hypoventilation, obesity, and dysautonomia. To date, only 14% of endocrinological disturbances have been reported in HIDEA patients. Better delineation of both syndromes is required to investigate the eventual involvement of P4HTM, a regulator of calcium dynamics and gliotransmission, in ROHHAD patients.Conclusion: In the case of clinical evidence of ROHHAD in a child with abnormal neurological development or eye abnormalities, we suggest that the P4HTM gene be systematically interrogated in addition to the analysis of the PHOX2B gene. A better delineation of the natural history of HIDEA is required to allow further comparisons between features of HIDEA and ROHHAD. The clinical similarities could potentially orient some molecular hypotheses in the field of ROHHAD research.
Perspectives on DMPA-SC for self-injection among adolescents with unmet need for contraception in Malawi
Authors: Ali Gracious , Porter Erlank Chelsey , Birhanu Frehiwot , Stanley Melinda , Chirwa Jessie , Kachale Fannie , Gunda Andrews 
Published: March 2023

IntroductionMalawi has made progress in expanding access to modern contraceptive methods over the last decade, including the introduction of depot-medroxyprogesterone acetate subcutaneous (DMPA-SC) in 2018. DMPA-SC offers women the option to self-inject at home and may benefit adolescents with unmet need for contraception due to its discretion. This qualitative study was conducted to assess perspectives and preferences of adolescents with unmet need for contraception regarding the self-injection option of DMPA-SC in Malawi.MethodsSix focus group discussions were conducted involving 36 adolescents with unmet need for contraception (aged between 15 and 19 years, married and never-married) in October 2021 in three districts in Malawi. Data were coded inductively and analyzed thematically, using Dedoose software. Two validation workshops were conducted with other adolescents with unmet need in February 2022 to elucidate the preliminary findings.ResultsDMPA-SC attributes such as discretion and reduced facility visits were ranked most appealing by both married and never-married adolescents, particularly for adolescents needing covert contraception use. Concerns about self-injection included fear of pain, injury, and doubt in ability to self-inject. Never-married adolescents had additional concerns around privacy at home if using covertly, and fears of affecting long-term fertility. Overall, health surveillance assistants (community-based healthcare workers) were voted to be the most private, convenient, and affordable sources for potential DMPA-SC self-injection training.ConclusionSelf-injection of DMPA-SC may offer an appealing option for adolescents in Malawi, aligning most closely to the needs of married adolescents who may wish to delay or space pregnancies conveniently and discreetly, and who also may face fewer access barriers to receiving self-injection training from health care providers. Access barriers including stigma and concerns about privacy at home for adolescents needing to use contraception covertly would need to be adequately addressed if never-married adolescents were to consider taking up this option.
Gender-based violence, religion and forced displacement: Protective and risk factors
Authors: Pertek Sandra , Block Karen , Goodson Lisa , Hassan Pakinam , Hourani Jeanine , Phillimore Jenny 
Published: March 2023

IntroductionThis paper examines the relationship between gender-based violence (GBV) and religion in a range of forced displacement contexts. While it has been acknowledged that religion frequently shapes experiences of GBV survivors, little is known about the influences of religion on GBV experiences in forced displacement and its potential role in strengthening interventions.MethodsUtilizing empirical evidence from 58 interviews from the SEREDA project with forced migrants in Sweden, UK, Turkey and Australia, we outline the interactions between religious resources and GBV in migrants' forced displacement experiences. We conceptualise religious resources as comprising religious ideas, religious practices, religious experience and religious organization.ResultsSurvivors talked about religion spontaneously when responding to questions relating to resilience, coping mechanisms, and risk factors. Religion acted as both a “protective” and “risk” factor for GBV experiences. Religious beliefs were assets in coping with GBV experiences, but also contributed to creating an environment in which violence was normalized, exposing women to further harm. Religious practices supported survivors emotionally to cope with GBV but also some practices posed risks. Religious organizations in many cases served as a lifeline for many displaced women, offering practical and emotional support, however religious leaders at times encouraged survivors to stay in abusive relationships. Religious experiences “empowered” and “disempowered” survivors across the processes of forced migration.DiscussionWe demonstrate the relevance and importance of acknowledging the role of religion in the experiences of GBV in forced displacement. Our analysis advances the understanding of religious resources as both protective and risk factors that affect forced migrants' experiences of GBV over time and place. We suggest a way forward for practitioners and researchers to account for the roles of religion in experiences of GBV and forced displacement, as opportunities and barriers to GBV prevention and response, and to work with religious leaders and local faith communities to strengthen protection of survivors.
Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials
Authors: Long Zhiyong , Xiang Wang , He Qi , Xiao Wei , Wei Huagen , Li Hao , Guo Hua , Chen Yuling , Yuan Mengxia , Yuan Xiao , Zeng Liuting , Yang Kailin , Deng Yuxuan , Huang Zhen 
Published: March 2023

ObjectiveTo evaluate safety and efficacy of dietary polyphenols in the treatment of rheumatoid arthritis (RA).MethodsCNKI, Pubmed, Cochrane library, Embase were searched to collect randomized controlled trials (RCTs) of dietary polyphenols in the treatment of RA. The databases were searched from the time of their establishment to November 8nd, 2022. After 2 reviewers independently screened the literature, extracted data, and assessed the risk of bias of the included studies, Meta-analysis was performed using RevMan5.4 software.ResultsA total of 49 records (47 RCTs) were finally included, involving 3852 participants and 15 types of dietary polyphenols (Cinnamon extract, Cranberry extract, Crocus sativus L. extract, Curcumin, Garlic extract, Ginger extract, Hesperidin, Olive oil, Pomegranate extract, Puerarin, Quercetin, Resveratrol, Sesamin, Tea polyphenols, Total glucosides of paeony). Pomegranate extract, Resveratrol, Garlic extract, Puerarin, Hesperidin, Ginger extract, Cinnamon extract, Sesamin only involve in 1 RCT. Cranberry extract, Crocus sativus L. extract, Olive oil, Quercetin, Tea polyphenols involve in 2 RCTs. Total glucosides of paeony and Curcumin involve in more than 3 RCTs. These RCTs showed that these dietary polyphenols could improve disease activity score for 28 joints (DAS28), inflammation levels or oxidative stress levels in RA. The addition of dietary polyphenols did not increase adverse events.ConclusionDietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc. However, more RCTs are needed to verify or modify the efficacy and safety of dietary polyphenols.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022315645.