bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental fatigue increases perception of effort but does not compromise the inhibitory control of football referees during a match simulation physical task
Authors: Lopes de Lima Cássio Zacarias , de Sousa Fortes Leonardo , Pires Daniel Alvarez , Souza Machado Hugo Enrico , Socorro Dantas Oliveira Andreza Do , Coswig Victor Silveira , Penna Eduardo Macedo 
Published: January 2025

AbstractExecutive functioning (EF) in referees is associated with their decision‐making during a match and can be affected by mental fatigue (MF), a psychobiological state induced by prolonged periods of cognitive activity or high cognitive demand within a short timeframe. Therefore, the aim of this study was to investigate the impact of MF on EF and the perception of effort during a physical task for football referees. Twelve male professional football referees were recruited (32 ± 7.3 years; 1.75 ± 0.06 cm; 85 ± 13.32 kg; 41.4 ± 5.92 mL kg−1 min−1 VO2max), visiting the laboratory on three occasions: one for characterization and familiarization and two experimental manipulations: high cognitive load (MF) and low cognitive load. After manipulations, they performed a physical task designed to replicate the physical demands of an official match. During the physical task, executive functioning was tested with a reaction time task and the ratings of perceived effort were assessed using subjective scales. The results revealed no effect of MF on response time performance (p = 0.395). However, higher perceptions of effort were observed in the high cognitive load condition (p = 0.018), which may impact physical performance. Despite the alteration in the perception of effort due to mental fatigue, executive function performance of football referees remained unimpaired.
Simultaneous Energy, Fresh Water, and Biogas Production Process Utilizing Solar Thermal and Sewage Sludge
Authors: Imandoust Milad , Alghorayshi Seyed Taher Kermani , Abbasi Solmaz , Seifollahi Mehran , Zahedi Rahim 
Published: January 2025

ABSTRACTMinimizing the detrimental effects of global warming and pollution from fossil fuel consumption is essential to meet the growing demand for energy and fresh water, making it imperative to adopt renewable energy alternatives. The integration of solar energy and biomass in hybrid renewable energy systems will grow in importance. The proposed study introduces a new design that facilitates the simultaneous production of power, biogas, and fresh water in a continuous process. The present research aims to tackle the challenge of utilizing multiple renewable energy sources, such as solar and biomass, to generate power, fuel, and fresh water. To achieve this, a 4‐stage multi‐effect desalination system will be employed for desalinating seawater. This paper discusses combining hybrid solar and biomass feedstocks to address the challenge of maintaining consistent energy production in renewable solar power plants at night, when there is no sunlight. The challenge at hand involves assessing various factors using ASPEN Plus software, such as solar heat transfer fluid (SHTF), sewage sludge flowrates, biogas production, output waste stream of gasification reactor, power generation, and freshwater production. Additionally, the payback period for this project is approximately 4.8 years, with a net present value (NPV) of around 560 million dollars. By performing a sensitivity analysis, the viability of the designed process and the quality of the resulting products were effectively demonstrated. From the gasification process, an impressive 76.8586 tons per hour of syngas, composed of carbon monoxide and hydrogen, was generated. Additionally, the power output of the system reached 34.547 MW, while simultaneously producing approximately 783 m3/h of fresh water. Due to efficient energy recovery throughout the entire process, only 25 MW of solar power was required. Despite efforts, fresh water production was only operating at a 50% productivity level. To supply the required solar energy during daylight hours, a total of 38,908 square meters of Parabolic trough collector (PTC) was necessary. According to the environmental analysis, the primary concern is the detrimental effect of pollution on human health. Solar collectors and sea water desalination units account for over 95% of the pollution. The revelation showed that combining solar and biomass energy resources could provide a sustainable solution to meet the rising demand for fresh water, electricity, and fuel.
Comparing Ultraviolet and Photocatalytic Disinfection Techniques and Their Synergistic Effects on Pesticide Presence and Quality Parameters in Grapes
Authors: Sindhu Susmitha , Lakshmipathy Kavitha , R Lithiyal , R Sushmithashri , K Manoj Aswin , C K Sunil , D Chidanand 
Published: January 2025

ABSTRACTThe efficacy of ultraviolet (UV) and photocatalytic disinfection techniques, individually and synergistically, in degrading pesticide residues and maintaining quality parameters in grapes were investigated. A bench‐scale photocatalytic reactor equipped with UV lamps and photocatalysts (TiO₂ and ZnO) was used for the treatments. LC‐MS/MS was employed to check the presence and absence of pesticide residues after UV and photocatalyst treatments. UV‐C treatment alone showed an absence of chlorpyrifos and cyprodinil pesticides, whereas UV‐C with TiO₂ or ZnO led to near‐complete degradation of all pesticides found in grapes. Quality assessments showed a reduction in total phenolic content (TPC) from 269.4 ± 36.2 to 239.7 ± 30.2 mg GAE/100 g with UV‐C alone, whereas addition of TiO₂ improved TPC to 273.2 ± 18.3 mg GAE/100 g. Total flavonoid content (TFC) decreased significantly to 17.04 mg QE/100 g with UV‐C, but less so with UV‐B and UV‐A. Ascorbic acid content dropped from 34.91 to 15.75 mg/L with UV‐C, but UV‐B and UV‐A retained more ascorbic acid. Microbial analysis showed a reduction in total plate count from 6.30 ± 0.04 to 3.19 ± 0.10 log CFU/g with UV‐C. Overall, the combined treatments of photocatalysts assisted with UV demonstrated an environmentally friendly method for enhancing grape safety and quality, presenting a viable alternative for postharvest disinfection.
Developmental Trajectories and Differences in Functional Brain Network Properties of Preterm and At‐Term Neonates
Authors: López‐Guerrero N. , Alcauter Sarael 
Published: January 2025

ABSTRACTPremature infants, born before 37 weeks of gestation can have alterations in neurodevelopment and cognition, even when no anatomical lesions are evident. Resting‐state functional neuroimaging of naturally sleeping babies has shown altered connectivity patterns, but there is limited evidence on the developmental trajectories of functional organization in preterm neonates. By using a large dataset from the developing Human Connectome Project, we explored the differences in graph theory properties between at‐term (n = 332) and preterm (n = 115) neonates at term‐equivalent age, considering the age subgroups proposed by the World Health Organization for premature birth. Leveraging the longitudinal follow‐up for some preterm participants, we characterized the developmental trajectories for preterm and at‐term neonates, for this purpose linear, quadratic, and log‐linear mixed models were constructed with gestational age at scan as an independent fixed‐effect variable and random effects were added for the intercept and subject ID. Significance was defined at p < 0.05, and the model with the lowest Akaike Information Criterion (AIC) was selected as the best model. We found significant differences between groups in connectivity strength, clustering coefficient, characteristic path length and global efficiency. Specifically, at term‐equivalent ages, higher connectivity, clustering coefficient and efficiency are identified for neonates born at later postmenstrual ages. Similarly, the characteristic path length showed the inverse pattern. These results were consistent for a variety of connectivity thresholds at both the global (whole brain) and local level (brain regions). The brain regions with the greatest differences between groups include primary sensory and motor regions and the precuneus which may relate to the risk factors for sensorimotor and behavioral deficits associated with premature birth. Our results also show non‐linear developmental trajectories for premature neonates, but decreased integration and segregation even at term‐equivalent age. Overall, our results confirm altered functional connectivity, integration and segregation properties of the premature brain despite showing rapid maturation after birth.
Disease characteristics and outcomes of acute myeloid leukemia in germline RUNX1 deficiency (Familial Platelet Disorder with associated Myeloid Malignancy)
Authors: Ernst Martijn P. T. , Versluis Jurjen , Valk Peter J. M. , Bierings Marc , Tamminga Rienk Y. J. , Hooimeijer Louise H. , Döhner Konstanze , Gresele Paolo , Tawana Kiran , Langemeijer Saskia M. C. , Van der Reijden Bert A. , Podgornik Helena , Sever Matjaz , Tvedt Tor H. A. , Vulliamy Tom , Fitzgibbon Jude , Dokal Inderjeet , Baliakas Panagiotis , Bastida José M. , Pohlkamp Christian , Haferlach Torsten , Larcher Lise , Soulier Jean , Schutgens Roger E. G. , Freson Kathleen , Duployez Nicolas , Löwenberg Bob , Ericson Katrin , Cammenga Jörg , Ripperger Tim , Raaijmakers Marc H. G. P. 
Published: January 2025

AbstractFamilial Platelet Disorder with associated Myeloid Malignancy (FPDMM, FPD/AML, RUNX1‐FPD), caused by monoallelic deleterious germline RUNX1 variants, is characterized by bleeding diathesis and predisposition for hematologic malignancies, particularly myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Clinical data on FPDMM‐associated AML (FPDMM‐AML) are limited, complicating evidence‐based clinical decision‐making. Here, we present retrospective genetic and clinical data of the largest cohort of FPDMM patients reported to date. We describe 159 European patients (from 94 families) of whom 134 were evaluable for the development of malignant disease. Sixty developed a hematologic malignancy (44.8%), most frequently AML (36/134, 26.9%) or MDS (18/134, 13.4%). Somatic alterations of RUNX1 by gene mutation (48%) and chromosome 21 aberrations (14.3%) were the most common somatic genetic aberrations in FPDMM‐AML, followed by FLT3‐ITD mutations (24.1%). Somatic RUNX1 and FLT3‐ITD mutations were not detected in FPDMM‐associated MDS, suggesting important contributions to leukemic transformation. Remission‐induction chemotherapy resulted in complete remission in 80% of FPDMM‐AML patients with a 5‐year overall survival (OS) of 50.4%. Survival outcome was non‐inferior compared to a large cohort of newly diagnosed adult RUNX1‐mutated AML (5‐year OS 36.6%, p = 0.5), with relatively infrequent concurrent adverse risk somatic aberrations (ASXL1 mutation, monosomal karyotype, monosomy 5/del 5q) in FPDMM‐AML. Collectively, data support the notion that step‐wise leukemic evolution in FPDMM is associated with distinct genetic events and indicate that a substantial subset of FPDMM‐AML patients achieves prolonged survival with conventional AML treatment, including allogeneic stem cell transplant. These findings are anticipated to inform personalized clinical decision‐making in this rare disorder.
Risk Factors and Pharmacological Interventions Impacting Cerebrovascular Ischemic Events in Giant Cell Arteritis: A Narrative Review
Authors: Siddiqui Muhammad Osama , Syed Mohammad Ali , Qureshi Ayaan Ahmed , Imam Mustafa Hussain , Motwani Jatin , Kumari Verkha , Siddiqui Arooba , Ul Ain Noor , Jaber Mohammed Hammad 
Published: January 2025

ABSTRACTIntroductionGiant cell arteritis (GCA) is a common vasculitis predominantly affecting larger vessels, especially in individuals aged 70–79. Cerebrovascular ischemic events (CIE), such as stroke and transient ischemic attacks, are serious but rare complications of GCA, with a pooled prevalence of 4%. Some studies found that within 2 weeks of GCA diagnosis, 74% and 34% of patients experience transient or severe ischemic events, respectively.AimsOur study aims to help physicians better manage GCA patients to reduce GCA‐related CIE by indicating important risk factors and pharmacological intervention to prevent GCA‐related CIE, particularly in the first few days of diagnosis when the risk of CIE is highest.MethodsA comprehensive literature search was conducted using Pubmed, Google Scholar, Scopus, and other relevant medical databases. As this study was a narrative review, the literature search was done in a nonsystematic manner. Studies published from 2000 to 2024 were reviewed in a nonsystematic manner for information on incidence, pathology, risk factors, pharmacological intervention, and management of GCA‐related CIE.ResultsFindings indicate that age, male gender, hypertension, and smoking significantly increase the risk of GCA‐related CIE, while factors such as anemia, higher body mass index (BMI), and elevated inflammatory markers (C‐reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) appear to have protective effects. Symptoms of ischemia in the ophthalmic artery were identified as the strongest predictors of CIE. Pharmacological treatments, including glucocorticoids and tocilizumab, are instrumental in managing and potentially preventing CIE in GCA patients, with adjunctive therapies such as aspirin and antiplatelet agents also showing promise.ConclusionGCA‐related CIE such as stroke can be very debilitating and deadly conditions, particularly when GCA is initially diagnosed. However, with early diagnosis and proper management of risk factors, GCA‐related CIE can be prevented and its severity can be reduced. Ischemia in the ophthalmic artery is found to strongly predict GCA‐related CIE while aspirin and antiplatelet agent during the first 3 months may prevent GCA‐related CIE. Risk factors such as BMI and smoking may help in stratifying the risk of GCA‐related CIE. This review underscores the importance of further studies with detailed, well‐designed approaches to risk factor analysis to strengthen these associations. Identifying these risk factors is crucial for reducing morbidity and mortality, equipping physicians to better assess and mitigate the risk of CIE in GCA patients.
Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion
Authors: Lauritzen Inger , Bini Anaïs , Bécot Anaïs , Gay Anne‐Sophie , Badot Céline , Pagnotta Sophie , Chami Mounia , Checler Frédéric 
Published: January 2025

AbstractEmerging evidence indicates that autophagy is tightly connected to the endocytic pathway. Here, we questioned the role of presenilins (PSENs 1 and 2), previously shown to be involved in autophagy regulation, in the secretion of small endocytic‐originating extracellular vesicles known as exosomes. Indeed, while wild‐type cells responded to stimuli promoting both multivesicular endosome (MVE) formation and secretion of small extracellular vesicles (sEVs) enriched in canonical exosomal proteins, PSEN‐deficient cells were almost unaffected to these stimuli. Moreover, in PSEN‐deficient cells, the re‐expression of either PSEN1 or the functional active PSEN1delta9 mutant led to a rescue of most sEV secretion, while the deletion of PSEN1 alone almost fully phenocopied total PSEN invalidation. We found that the lack of sEV secretion in PSEN‐deficient cells was also due to overactivated autophagy promoting MVEs to degradation rather than to plasma membrane fusion. Hence, in these cells, the autophagic blocker bafilomycin A1 (BafA1) not only increased the intracellular levels of the MVE protein CD63, but also turned on sEV secretion by stimulating autophagy‐dependent unconventional secretion. In that case, sEVs arised from amphisomes and were enriched in both canonical exosomal proteins and lysosomal‐autophagy‐associated cargo. Altogether, we here demonstrate that PSENs, and particularly PSEN1, act as hub proteins controlling the balance between endosomal/autophagic degradation and secretion. More generally, our findings strengthen the view of a strong interconnection between the endocytic and autophagic pathways and their complementary roles in sEV secretion.
Genetic medicine of familial and hereditary pancreatic cancer: Recent update in the era of precision cancer medicine
Authors: Matsubayashi Hiroyuki , Kiyozumi Yoshimi , Ono Hiroyuki 
Published: January 2025

AbstractIn Japan, 5 years have passed since the initiation of precision cancer medicine, and recent data accumulation in familial pancreatic cancer (FPC) and hereditary pancreatic cancer is outstanding. Multigene germline panel tests (MGPTs) have revealed that 7%–18% of patients with pancreatic cancer (PC) harbor pathogenic germline variants (PGVs), almost equal to the levels of breast, ovarian, endometrial, and colorectal cancers, with a higher incidence in FPC (14%–26%). The majority of PGVs seen in PC patients are clinically actionable and associated with homologous recombination (HR) pathways (6%–10%, particularly BRCA1/2 in 5%–6%), and the clinical guidelines recommend or propose genetic testing for all PC patients. Consensus guidelines have been established for most of the hereditary syndromes associated with PC risks, and surveillances of the pancreas and other at‐risk organs are recommended for PGV carriers. Hereditary breast and ovarian cancer (HBOC) is the commonest hereditary cancer syndrome that has moderately increasing life‐time risks of PC (3%–7% in Western countries); however, recent Japanese research demonstrated a higher risk level (BRCA1: 16%, BRCA2: 14%). Moreover, recent evidence has suggested a risk linkage between PC and ovarian cancer in HBOC pedigrees. High scores of homologous recombination deficiency suggest biallelic dysfunction of BRCA or other HR‐related genes, and the likely effectiveness of platinum agents and PARP inhibitors against PCs. Remote counseling and testing are possible option in the future genetic medicine. As PC ranks in the second commonest target of precision cancer medicine in Japan, we must treat the patients and manage their at‐risk relatives efficiently.
“Privacy Is a Privilege”: A Thematic Analysis of the Concerns and Advice of Canadians Crowdfunding for Basic Living Needs
Authors: Grewal Ashmita , Snyder Jeremy , Crooks Valorie 
Published: January 2025

ABSTRACTCrowdfunding campaigners can struggle with protecting their personal information while providing a compelling case for why their campaign is worthy of support. Little research has examined donation‐based crowdfunding campaigners' experience of protecting their sensitive health‐related information while trying to meet their fundraising goals. Our research uses semi‐structured interviews to explore the concerns of donation‐based crowdfunding campaigners who are raising funding for health and/or housing‐related reasons, which can be considered basic‐living needs. Participants were primarily recruited through two methods: identifying potential participants through a database of scraped crowdfunding campaigns and posting calls for participants on Twitter, Craigslist, and Reddit. We interviewed 24 participants from Canada. All participants were above the age of 19 and crowdfunded for their own health and/or housing‐related needs. Thematic analysis was conducted to identify broad domains that encapsulate participants' privacy concerns and the advice they have for others related to privacy protection. Participants identified three areas of privacy‐related concerns arising from their experience of creating a crowdfunding campaign for themselves: (1) the public nature of crowdfunding campaigns and related harms; (2) being messaged or intrusively probed by potential donors; and (3) the information collection and sharing by platforms. Based on their experiences of crowdfunding, participants recommended people considering starting a crowdfunding campaign to be both cautious and specific; be informed; and consider the uncertainties related to the practice of crowdfunding. Our analysis indicates campaigners are often unaware of the significant pressures they will face to give up their privacy in exchange for financial support. Participants' privacy‐related concerns are complex and intertwined. Better intervention from crowdfunding platforms and government policymakers can help better inform and protect these campaigners.
The Study of the Skeletal Remains of the 16th Century Italian Commander Alessandro Farnese and His Wife, Maria D'Aviz
Authors: Donato Laura , Cucurachi Nicola , Ubelaker Douglas H. , Armocida Emanuele , Camatti Jessika , Treglia Michele , Marsella Luigi Tonino , Cecchi Rossana 
Published: January 2025

ABSTRACTEntheseal changes are indicators of persistent and long‐term changes induced by occupational activity and refer to marks on the skeleton where a muscle, tendon, or ligament inserts into the periosteum. Their study makes it possible to deduce further information about the person to whom the human bone remains belong. The authors present here the analysis of these markers on the bone remains of two Italian historical figures who lived in the 16th century. In 2021, the exhumation of the remains of Alessandro Farnese and Maria D'Aviz was authorized for study purposes and the skeletal remains were examined. The data collected from the examination of the mortal remains of Alessandro Farnese are compatible with historical data about his biography. As a skilled leader and assiduous sportsman, he showed signs of entheseal changes in his bone tissue attributable to physical activities. On the other hand, the case of Maria D'Aviz differs significantly from that of Alessandro Farnese in that her bone segments show no signs of entheseal changes. The analysis carried out on the remains results to be very useful in verifying the comparison with the elements present in their biography. The possibility of confirming the connection between entheseal changes and lifestyle habits is fundamental to increasing credibility in the application of these elements in the process of identifying nameless bodies in the forensic context.