bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender diversity and leadership in Radiation Oncology in Australia and New Zealand
Authors: Hesselberg Gina , James Melissa , Turner Sandra , Gupta Nishant , Mackenzie Penny 
Published: February 2023

AbstractIntroductionThere has been a groundswell of discussion and activism surrounding gender diversity. Given the growing importance of this issue, a working group was established under the Faculty of Radiation Oncology (FRO) of the Royal Australian and New Zealand College of Radiologists' (RANZCR) Economics and Workforce Committee (EWC) to review the current status of gender diversity within radiation oncology (RO) in Australia and New Zealand.MethodsDe‐identified data were provided from two recent FRO workforce censuses conducted in 2014 and 2018 with permission from the EWC. Further data were provided via direct correspondence with staff at the RANZCR and the Trans‐Tasman Radiation Oncology Group (TROG), the major RO research group in Australasia. The data were collated in February 2021.ResultsOur results showed that compared to females, male radiation oncologists were more likely to be engaged in full‐time active clinical work, hold a postgraduate degree and obtain a consultant or fellowship position following graduation. Male fellows were more likely to have leadership positions within RANZCR and TROG and self‐identify as holding any leadership position. The 2018 census revealed that within the trainee cohort, there was almost an equal number of male and female trainees as well as an equal number of male and female trainees holding a postgraduate degree.ConclusionThis review is an important first exploration into gender diversity across Australia and New Zealand's RO workforce. Whilst our study indicates that gender disparities exist, there are some indications that this may be equalizing out over time.
SAPHO syndrome with Takayasu arteritis successfully treated with tofacitinib
Authors: Ru Chen , Qian Tangliang , Liu Xiaoping , Wang Chaoxin , Li Weizhong , Hou Xiujuan , Li Chen 
Published: February 2023

AbstractSAPHO syndrome is an autoinflammatory disease with a variety of clinical manifestations, which may be accompanied by other systemic inflammatory diseases in addition to the typical manifestations of common synovitis, acne, pustulosis, hyperostosis, and osteitis. Here, we report the first case of SAPHO syndrome combined with Takayasu arteritis.
Serious spondylodiscitis, septic sacroiliitis and multiple abscesses after ozone therapy for low back pain: A case report on good response to combined treatment with empiric antibiotic and neridronate
Authors: Erroi Francesca , Rotondo Cinzia , Sciacca Stefania , Trotta Antonello , Cantatore Francesco Paolo , Corrado Addolorata 
Published: February 2023

AbstractOzone therapy is a minimally invasive technique now widely used for the treatment of pain due to herniated discs. In literature there are conflicting results concerning its real effectiveness and few data about its possible complications. In this case report we present a case of spondylodiscitis, septic arthritis and gluteal abscess following the execution of 4 sessions of ozone therapy. Given the impossibility of isolating the etiological agent, an empirical antibiotic therapy with an overall duration of 6 weeks was set up, initially with daptomycin and ceftriazone, to which was added after 2 days metronidazole, administered intravenously; after 20 days the cephalosporin was replaced with oral amoxicillin/clavulanate. Neridronate was added to treat bone edema and to avoid bone erosion. The patient showed improvement of both clinical conditions and inflammation indexes, and was discharged after 4 weeks without further complications at follow‐up. Few cases are reported in the literature about spondylodiscitis secondary to ozone treatment, and just 1 case is described about the use of neridronate as additive drug to antibiotic treatment in spondylodiscitis to avoid bone disruption and surgery complications.
Real‐world practice in Peyronie's disease management: Results from a national survey of urologists
Authors: Brant Aaron , Basourakos Spyridon P. , Lewicki Patrick , Kang Caroline , Marinaro Jessica , Punjani Nahid , Kashanian James A. 
Published: February 2023

AbstractBackgroundDespite many available treatments for Peyronie's disease (PD), practice patterns of available therapeutics are not well characterized.ObjectiveWe conducted a national survey of urologists to characterize real‐world practice patterns of PD management and to characterize the use of therapies discouraged by the American Urological Association guidelines on PD management.Materials and methodsA 34‐item survey was distributed via RedCap to urologists who treat patients with PD in all American Urological Association sections. Questions elicited demographic information as well as practices in the diagnosis and treatment of PD. Comparisons were made with Pearson's chi‐squared test. The primary outcome was reported use of therapies discouraged by the American Urological Association guidelines on PD.ResultsA total of 145 respondents completed the survey, of whom 19% were fellowship trained in andrology/sexual medicine, 36% practiced in an academic setting, and 50% had at least 20 years in practice. Only 60% of respondents reporting performing in‐office curvature assessment prior to commencing intralesional injection or surgical treatment, with higher prevalence in andrology/sexual medicine fellowship‐trained versus non‐fellowship‐trained urologists (85% vs. 54%, p = 0.003). The most popular treatment modalities were collagenase clostridium histolyticum (61% of respondents), phosphodiesterase‐5 inhibitors (54%), and penile traction (53%). Twenty‐one percent of respondents reported currently using a treatment that is explicitly discouraged by the American Urological Association guidelines (extracorporeal shockwave therapy for curvature, L‐carnitine, omega‐3 fatty acids, or vitamin E).DiscussionPatients seeking PD treatment may be offered different therapies, some of which are not evidence‐based, depending on the treating urologist. This study is limited by self‐selection and response bias. Its strength is that it represents a cross‐sectional overview of real‐world practice patterns in PD management, which has not been previously described.ConclusionsA significant proportion of urologists reported PD management practices that are not evidence‐based and not guideline‐supported.
Limb salvage surgery reconstructive techniques following long‐bone lower limb oncological resection: a systematic review and meta‐analysis
Authors: Hovav Oliver , Kolonko Sarah , Zahir Syeda Farah , Velli Gina , Chouhan Prem , Wagels Michael 
Published: February 2023

AbstractBackgroundLimb salvage surgery (LSS) is now considered the gold standard surgical treatment for lower limb bone sarcomas. However, there is a paucity of literature comparing the various LSS reconstructive options. The aim of this systematic review and meta‐analysis was to compare functional outcomes and complications of LSS reconstructive techniques.MethodsThe primary aim of the meta‐analysis was to determine functional outcomes from the pooled data utilizing the Musculoskeletal Tumour Society score (MSTS). Comparisons could then made for this outcome between biological and prosthetic, vascularised and non‐vascularised, and prosthetic and composite reconstructions. The secondary aim was to compare complication outcomes of each reconstruction. Standardized mean difference (Cohen's d) and odds ratios were estimated using a random effects model.ResultsFourteen studies with a total of 785 patients were included. We found structural failure was 75% less likely to occur in prosthetic reconstruction compared to biological (OR = 0.24; 95% CI: 0.07–0.79; P = 0.02). We did not find any evidence of difference in function (MSTS score) between vascularised verses non‐vascularised reconstructions (Cohen's d = −1.14; 95% CI = −3.06 to 0.78; I2 = 87%). Other analyses comparing complications found no difference between the reconstructive groups.ConclusionThe study found no correlation between functional outcomes and the type of LSS reconstruction. Structural failure was more likely to occur in biological when compared with prosthetic reconstruction. There was no correlation between the incidence of other complications and the type of LSS technique. This suggests a role for improved approaches to reconstruction methods including bioprinting and bioresorbable devices.
Pulmonary important outcomes after extremely preterm birth: Parental perspectives
Authors: Thivierge Emilie , Luu Thuy Mai , Bourque Claude Julie , Barrington Keith J. , Pearce Rebecca , Jaworski Magdalena , Janvier Annie 
Published: February 2023

AbstractAimTo describe pulmonary important outcomes (PIO) reported by parents of children born extremely preterm.MethodsOver 1‐year, all parents of children aged 18 months–7‐years born <29 weeks' GA were asked regarding their perspectives. The proportion of parents who described PIO and the themes they invoked were examined. Results were analysed using mixed methods.ResultsAmong parental responses (n = 285, 98% participation rate), 44% spoke about PIO, invoking 24 themes pertaining to NICU hospitalisation and/or long‐term respiratory health. Some themes had an impact primarily on the child (e.g. exercise limitation), while the majority had an impact on the whole family (e.g. hospital readmissions). None mentioned oxygen at 36 weeks nor bronchopulmonary dysplasia (BPD). The proportion of responses invoking PIO were statistically similar between parents of children with and without BPD, born before or after 25 weeks or with birthweight < or ≥750 g. PIO were more likely to be mentioned in males and among those readmitted for respiratory problems.ConclusionParents describe many PIO, most related to the functional impact of lung disease on their child (and family), rather than the diagnosis of BPD itself. Most of these PIO are not primary outcomes in large neonatal trials nor collected in neonatal databases.
Letter: comment on Park et al – the association of non‐alcoholic fatty liver disease between parents and adolescent children – authors' reply
Authors: Park Yewan , Sinn Dong Hyun , Gwak Geum‐Youn 
Published: February 2023

LINKED CONTENTThis article is linked to Park et al papers. To view these articles, visit https://doi.org/10.1111/apt.17257 and https://doi.org/10.1111/apt.17390
Oral mucosal graft ureteroplasty versus ileal ureteric replacement: a meta‐analysis
Authors: You Yongqiang , Gao Xincheng , Chai Shuaishuai , Chen Jiawei , Wang Jianli , Zhang Hao , Zhou Yuancheng , Yu Zehao , Cheng Gong , Li Bing , Xiao Xingyuan 
Published: February 2023

ObjectivesTo describe outcomes of oral mucosal graft ureteroplasty (OMGU) and ileal ureter replacement (IUR) and determine the relative merits of both procedures.MethodsDatabases (including PubMed, Embase and Cochrane) were interrogated for eligible trials that assessed outcomes of OMGU or IUR from 2000 to 30 July 2022. The variables analysed were reconstruction success rates, stricture length, hospital stays, perioperative complications and long‐term complications.ResultsA total of 23 single‐arm studies were included. The pooled reconstruction success rates for OMGU and IUR were 94.9% (95% confidence interval [CI] 91.0%–97.7%) and 85.8% (95% CI 81.0%–90.0%), respectively. Stricture length of patients in the OMGU and IUR groups were 3.73 (95% CI 3.17–4.28) and 11.55 (95% CI 9.82–13.29) cm, respectively. The maximal stricture length repaired by OMGU was 8 cm. The hospital stays were 5.85 (95% CI 3.88–7.82) and 11.55 (95% CI 6.93–16.17) days in the OMGU and IUR groups, respectively. The incidences of low‐grade postoperative complications were 13.6% (95% CI 6.9%–20.3%) and 27.3% (95% CI 19.5%–35.1%), high‐grade postoperative complications were 4.6% (95% CI 1.8I–8.5%) and 13.0% (95% CI 9.4%–17.1%), and long‐term complications (occurred at > 3months) were 9.0% (95% CI 1.7%–20.0%) and 35.4% (95% CI 25.8%–45.6%) in the OMGU and IUR groups, respectively.ConclusionAn OMGU is an effective, minimally invasive, and safe alternative to IUR for the management of long ureteric strictures. OMGU was the preferred treatment for long ureteric strictures, especially obstructed ureter segments of ≤8 cm.
Multigenerational care or parental care? Familial care types, social–emotional development and mediation of parent–child relationship of single‐parent children in mainland China
Authors: Wang Miao , Fan Yao , Zhang Qingzhu , Sun Qian , Wan Guowei , Hong Jun Sung 
Published: February 2023

AbstractChildren from single‐parent families are at risk for problems related to social–emotional development (SED). This study investigated the associations between familial care types and single‐parent children's SED, and the possible pathways through the mediation of parent–child relationship. This study analysed 431 single‐parent children (50.0% girls) drawn from a local database with a total of 2507 children studying in Grades 4 to 8. We compared the SED of single‐parent children in multigenerational care and those in parental care. We then tested the possible mediating effect of parent–child relationship between familial care types and children's SED. The study found that there were no deficits in the SED of single‐parent children in multigenerational care compared with those in parental care. Multigenerational care had no direct relationship with the SED of single‐parent children after the mediator of the parent–child relationship was entered. The parent–child relationship mediated the associations between familial care types and four dimensions of the single‐parent children's SED. These findings provided support for multigenerational and parental care, and also directions for family care strategies and developing social service programmes to promote the SED of single‐parent children in China.
Microreticular perineurioma: A new morphological subtype of a rare entity
Authors: Salah Haneen T. , D'ardis Julieta A. , Enos Tyler , Klimas Natasha , Gerber Howard B. 
Published: February 2023

AbstractPerineurioma is a benign peripheral nerve sheath tumor. Several subtypes have been described, including plexiform, reticular, and sclerosing. The reticular variant has been previously described as having a net or lace‐like growth pattern consisting of large anastomosing cords of spindle‐shaped cells. We report a case of an 11‐year‐old male who presented with a 2‐year history of a slowly enlarging, tan‐white lesion on the finger. Microscopically, the lesion consisted of cells with ovoid nuclei and delicate, elongate cytoplasmic processes, arranged in a microreticular pattern. The lesional cells were markedly positive for epithelial membrane antigen and claudin‐1. Based on these features and the unusual morphology, the case was called a microreticular perineuroma. The patient underwent complete excision of the lesion with no recurrence 9 months after follow‐up. To our knowledge, this is the first reported case of this morphologic variant. Awareness of this entity is important to avoid inappropriate management.
How does e‐commerce demonstration city improve urban innovation? Evidence from China
Authors: Zhou Cai , Li Bowen 
Published: February 2023

AbstractThis paper provides a feasible way to realize urban innovation through the e‐commerce pilot. Based on the data of 289 cities in China from 2002 to 2019, we examine the impact of the National E‐commerce Demonstration City pilot on urban innovation with a staggered difference‐in‐differences method. The results show that after becoming a pilot city of National E‐commerce Demonstration Cities (NEDC), the quantity and quality of urban innovation have improved. Further, NEDC policy plays a greater role in promoting innovation in economically agglomerated areas, first‐and third‐tier cities and areas with a higher degree of marketization. Finally, NEDC policy can affect the level of urban innovation by optimizing the allocation of innovation factors, improving the efficiency of credit resource allocation and forming the logistics scale effect.
Brentano's theory of intentionality
Authors: Montague Michelle 
Published: February 2023

AbstractChapters Five through Nine of Book Two of Brentano's 1874 Psychology From an Empirical Standpoint were republished in 1911 with a substantive Appendix of Brentano's remarks. In the Appendix Brentano makes a significant addition to his theory of intentionality. In particular, he introduces new modes within the mode of presentation itself. These new modes are needed to account for our thinking about anything in a relational structure (in recto and in obliquo modes) and for our thoughts about time (the temporal mode). I want to suggest that in the end Brentano simply takes relations to be different kinds of modes.
Extending eco‐evolutionary theory with oligomorphic dynamics
Authors: Lion Sébastien , Sasaki Akira , Boots Mike 
Published: February 2023

AbstractUnderstanding the interplay between ecological processes and the evolutionary dynamics of quantitative traits in natural systems remains a major challenge. Two main theoretical frameworks are used to address this question, adaptive dynamics and quantitative genetics, both of which have strengths and limitations and are often used by distinct research communities to address different questions. In order to make progress, new theoretical developments are needed that integrate these approaches and strengthen the link to empirical data. Here, we discuss a novel theoretical framework that bridges the gap between quantitative genetics and adaptive dynamics approaches. ‘Oligomorphic dynamics’ can be used to analyse eco‐evolutionary dynamics across different time scales and extends quantitative genetics theory to account for multimodal trait distributions, the dynamical nature of genetic variance, the potential for disruptive selection due to ecological feedbacks, and the non‐normal or skewed trait distributions encountered in nature. Oligomorphic dynamics explicitly takes into account the effect of environmental feedback, such as frequency‐ and density‐dependent selection, on the dynamics of multi‐modal trait distributions and we argue it has the potential to facilitate a much tighter integration between eco‐evolutionary theory and empirical data.
A pharmacokinetic model of antiseizure medication load to guide care in the epilepsy monitoring unit
Authors: Ghosn Nina J. , Xie Kevin , Pattnaik Akash R. , Gugger James J. , Ellis Colin A. , Sweeney Elizabeth , Fox Emily , Bernabei John M. , Johnson Jenaye , Boccanfuso Jacqueline , Litt Brian , Conrad Erin C. 
Published: February 2023

AbstractObjectiveEvaluating patients with drug‐resistant epilepsy often requires inducing seizures by tapering antiseizure medications (ASMs) in the epilepsy monitoring unit (EMU). The relationship between ASM taper strategy, seizure timing, and severity remains unclear. In this study, we developed and validated a pharmacokinetic model of total ASM load and tested its association with seizure occurrence and severity in the EMU.MethodsWe studied 80 patients who underwent intracranial electroencephalographic recording for epilepsy surgery planning. We developed a first order pharmacokinetic model of the ASMs administered in the EMU to generate a continuous metric of overall ASM load. We then related modeled ASM load to seizure likelihood and severity. We determined the association between the rate of ASM load reduction, the length of hospital stay, and the probability of having a severe seizure. Finally, we used modeled ASM load to predict oncoming seizures.ResultsSeizures occurred in the bottom 50th percentile of sampled ASM loads across the cohort (p < .0001, Wilcoxon signed‐rank test), and seizures requiring rescue therapy occurred at lower ASM loads than seizures that did not require rescue therapy (logistic regression mixed effects model, odds ratio = .27, p = .01). Greater ASM decrease early in the EMU was not associated with an increased likelihood of having a severe seizure, nor with a shorter length of stay.SignificanceA pharmacokinetic model can accurately estimate ASM levels for patients in the EMU. Lower modeled ASM levels are associated with increased seizure likelihood and seizure severity. We show that ASM load, rather than ASM taper speed, is associated with severe seizures. ASM modeling has the potential to help optimize taper strategy to minimize severe seizures while maximizing diagnostic yield.
Are mergers and acquisitions beneficial to consumers? Evidence from the property‐liability insurance industry
Authors: Shim Jeungbo 
Published: February 2023

AbstractWe examine price changes associated with mergers and acquisitions (M&As) in the U.S. property‐liability insurance industry. We classify M&As into intrastate M&As, where the acquirer and the target previously operated in the same local market, and interstate M&As, where the acquirer and the target operated in different local markets. We show that insurance prices of acquiring firms decrease following interstate M&As, whereas there is no significant effect of M&As on price changes in intrastate consolidation. Using an interaction term between interstate M&A indicators and acquirers’ efficiency, we find evidence to suggest that acquirers’ efficiency can explain the price decrease in interstate M&As. It appears that acquirers’ efficiency can be passed on to consumers, and interstate M&As have a beneficial effect on consumers in the form of reduced prices.
Ediacaran–Cambrianbioturbation did not extensively oxygenate sediments in shallow marine ecosystems
Authors: Cribb Alison T. , van de Velde Sebastiaan J. , Berelson William M. , Bottjer David J. , Corsetti Frank A. 
Published: February 2023

AbstractThe radiation of bioturbation during the Ediacaran–Cambrian transition has long been hypothesized to have oxygenated sediments, triggering an expansion of the habitable benthic zone and promoting increased infaunal tiering in early Paleozoic benthic communities. However, the effects of bioturbation on sediment oxygen are underexplored with respect to the importance of biomixing and bioirrigation, two bioturbation processes which can have opposite effects on sediment redox chemistry. We categorized trace fossils from the Ediacaran and Terreneuvian as biomixing or bioirrigation fossils and integrated sedimentological proxies for bioturbation intensity with biogeochemical modeling to simulate oxygen penetration depths through the Ediacaran–Cambrian transition. Ultimately, we find that despite dramatic increases in ichnodiversity in the Terreneuvian, biomixing remains the dominant bioturbation behavior, and in contrast to traditional assumptions, Ediacaran–Cambrian bioturbation was unlikely to have resulted in extensive oxygenation of shallow marine sediments globally.