bluuebunny/crossref_metadata_2025_split huggingface dataset:
CCKAR is a biomarker for prognosis and asynchronous brain metastasis of non-small cell lung cancer
Authors: Liang Nan , Sun Suohui , Li Zheng , Wu Tao , Zhang Chunpu , Xin Tao 
Published: January 2023

BackgroundNon-small cell lung cancer (NSCLC) is the most common histological type of lung cancer, and brain metastasis (BM) is the most lethal complication of NSCLC. The predictive biomarkers and risk factors of asynchronous BM are still unknown.Materials and methodsA total of 203 patients with NSCLC were enrolled into our cohort and followed up. The clinicopathological factors such as tumor size, T stage, lymphatic invasion, metastasis and asynchronous BM were investigated. CCKAR expression in NSCLC and resected BM was assessed by IHC, and CCKAR mRNAs in NSCLC and para-tumor tissues were estimated by qRT-PCR. The correlations between CCKAR expression, BM and other clinicopathological factors were assessed by chi-square test, and prognostic significance of CCKAR was estimated by univariate and multivariate analyses.ResultsCCKAR was highly expressed in NSCLC tissues compared with para-tumor tissues. CCKAR expression in NSCLC was significantly associated with asynchronous BM. The BM percentages for NSCLC patients with low and high CCKAR were surprisingly 5.2% and 66.6%, respectively. CCKAR expression and BM were unfavorable factors predicting unfavorable outcome of NSCLC. Moreover, CCKAR expression in NSCLC was an independent risk factor of asynchronous BM.ConclusionsCCKAR is a prognostic biomarker of NSCLC. CCKAR expression in NSCLC is positively associated with asynchronous BM, and is a risk factor of asynchronous BM from NSCLC.
A novel homozygous SLC39A14 variant in an infant with hypermanganesemia and a review of the literature
Authors: Zhang Meijiao , Zhu Liping , Wang Huiping , Hao Ying , Zhang Qingping , Zhao Chunyan , Bao Xinhua 
Published: January 2023

BackgroundManganese (Mn) is an essential trace metal necessary for good health; however, excessive amounts in the body are neurotoxic. To date, three genes (SLC30A10, SLC39A8, and SLC39A14) have been discovered to cause inborn errors in Mn metabolism in humans. As very rare diseases, the clinical features require further clarification.MethodsA male Chinese patient who mainly presented with hypermanganesemia and progressive parkinsonism–dystonia was recruited for this study. We collected and analyzed clinical information, performed whole-exome sequencing (WES), and reviewed the relevant literature.ResultsThe motor-developmental milestones of the patient were delayed at the age of 4 months, followed by rapidly progressive dystonia. The patient displayed elevated Mn concentrations in blood and urine, and brain magnetic resonance imaging (MRI) showed symmetrical hyperintensity on T1-weighted images and hypointensity on T2-weighted images in multiple regions. A novel homozygous variant of the SLC39A14 gene (c.1058T &gt; G, p.L353R) was identified. The patient was treated with disodium calcium edetate chelation (Na2CaEDTA). Three months later, mild improvement in clinical manifestation, blood Mn levels, and brain MRI was observed. To date, 15 patients from 10 families have been reported with homozygous mutations of SLC39A14, with a mean age of onset of 14.9 months. The common initial symptom is motor regression or developmental milestone delay, with a disease course for nearly all patients involving development of progressive generalized dystonia and loss of ambulation before treatment. Additionally, hypermanganesemia manifests as Mn values ranging from 4- to 25-fold higher than normal baseline levels, along with brain MRI results similar to those observed in the recruited patient. Nine SLC39A14 variants have been identified. Seven patients have been treated with Na2CaEDTA, and only one patient achieved obvious clinical improvement.ConclusionWe identified a novel SLC39A14 mutation related to autosomal recessive hypermanganesemia with dystonia-2, which is a very rare disease. Patients present motor regression or delay of developmental milestones and develop progressive generalized dystonia. Chelation therapy with Na2CaEDTA appears to effectively chelate Mn and increase urinary Mn excretion in some cases; however, clinical response varies. The outcome of the disease was unsatisfactory. This study expands the genetic spectrum of this disease.
Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation
Authors: Wang Lusheng , Yang Kaiye , Jing Rongrong , Zhao Wengang , Guo Keke , Hu Zhenlin , Liu Guangrong , Xu Nuo , Zhao Jungang , Lin Li , Gao Shuang 
Published: January 2023

Background: Exposure to ultraviolet B (UVB) radiation can damage the epidermis barrier function and eventually result in skin dryness. At present, little work is being devoted to skin dryness. Searching for active ingredients that can protect the skin against UVB-induced dryness will have scientific significance.Methods:Saussurea involucrata polysaccharide (SIP) has been shown to have significant antioxidant and anti-photodamage effects on the skin following UVB irradiation. To evaluate the effect of SIP on UVB-induced skin dryness ex vivo, SIP-containing hydrogel was applied in a mouse model following exposure to UVB and the levels of histopathological changes, DNA damage, inflammation, keratinocyte differentiation, lipid content were then evaluated. The underlying mechanisms of SIP to protect the cells against UVB induced-dryness were determined in HaCaT cells.Results: SIP was found to lower UVB-induced oxidative stress and DNA damage while increasing keratinocyte differentiation and lipid production. Western blot analysis of UVB-irradiated skin tissue revealed a significant increase in peroxisome proliferator-activated receptor-α (PPAR-α) levels, indicating that the underlying mechanism may be related to PPAR-α signaling pathway activation.Conclusions: By activating the PPAR-α pathway, SIP could alleviate UVB-induced oxidative stress and inhibit the inflammatory response, regulate proliferation and differentiation of keratinocytes, and mitigate lipid synthesis disorder. These findings could provide candidate active ingredients with relatively clear mechanistic actions for the development of skin sunscreen moisturizers.
Revisiting differential control of sympathetic outflow by the rostral ventrolateral medulla
Authors: Kulkarni Soumya S. , Mischel Nicholas A. , Mueller Patrick J. 
Published: January 2023

The rostral ventrolateral medulla (RVLM) is an important brain region involved in both resting and reflex regulation of the sympathetic nervous system. Anatomical evidence suggests that as a bilateral structure, each RVLM innervates sympathetic preganglionic neurons on both sides of the spinal cord. However, the functional importance of ipsilateral versus contralateral projections from the RVLM is lacking. Similarly, during hypotension, the RVLM is believed to rely primarily on withdrawal of tonic gamma aminobutyric acid (GABA) inhibition to increase sympathetic outflow but whether GABA withdrawal mediates increased activity of functionally different sympathetic nerves is unknown. We sought to test the hypothesis that activation of the ipsilateral versus contralateral RVLM produces differential increases in splanchnic versus adrenal sympathetic nerve activities, as representative examples of functionally different sympathetic nerves. We also tested whether GABA withdrawal is responsible for hypotension-induced increases in splanchnic and adrenal sympathetic nerve activity. To test our hypothesis, we measured splanchnic and adrenal sympathetic nerve activity simultaneously in Inactin-anesthetized, male Sprague-Dawley rats during ipsilateral or contralateral glutamatergic activation of the RVLM. We also produced hypotension (sodium nitroprusside, i.v.) before and after bilateral blockade of GABAA receptors in the RVLM (bicuculline, 5 mM 90 nL). Glutamate (100 mM, 30 nL) injected into the ipsilateral or contralateral RVLM produced equivalent increases in splanchnic sympathetic nerve activity, but increased adrenal sympathetic nerve activity by more than double with ipsilateral injections versus contralateral injections (p &lt; 0.05; n = 6). In response to hypotension, increases in adrenal sympathetic nerve activity were similar after bicuculline (p &gt; 0.05), but splanchnic sympathetic nerve activity responses were eliminated (p &lt; 0.05; n = 5). These results provide the first functional evidence that the RVLM has predominantly ipsilateral innervation of adrenal nerves. In addition, baroreflex-mediated increases in splanchnic but not adrenal sympathetic nerve activity are mediated by GABAA receptors in the RVLM. Our studies provide a deeper understanding of neural control of sympathetic regulation and insight towards novel treatments for cardiovascular disease involving sympathetic nervous system dysregulation.
Meta-analysis of the intervention effects of taekwondo on metabolic syndrome indicators
Authors: Han Zhengfa , Ju Hanyu 
Published: January 2023

Objective: To quantify the effect of taekwondo as an intervention on the indicators of metabolic syndrome and identify an intervention plan with the optimal effects.Methods: Combining the Cnki.net, Wanfang, PubMed, Web of Science, Embase, KISS, RISS, and DBPIA databases, this paper retrieved relevant references in Chinese, English, and Korean, applied Review Manager 5.4 software to evaluate the methodological quality of the included references according to the Cochrane manual, and utilized Comprehensive Meta-Analysis version 3.7 to perform statistical analyses.Result: A total of 45 references and 1079 related subjects were included in the analysis. The results of the meta-analysis showed that taekwondo has a beneficial effect on all indicators of metabolic syndrome (Hedges’ g [effect size] = −0.615, −0.672, −0.497, −0.785, −0.591, and 0.435; p &lt; 0.05). Subgroup analysis revealed the superior intervention effect of taekwondo on metabolic syndrome in women compared to men, middle-aged and elderly compared to other age groups, and abnormal metabolic syndrome indicators compared to normal values. Moreover, the best results were obtained for longer intervention durations—12 weeks—three times per week, for 40–50 min per session. In addition, the combination of intervention types (poomsae, kick, and taekwondo gymnastics) showed optimal effects. The exercise intensity should consider the characteristics of the intervention object and be generally set to medium or high intensity.Conclusion: Taekwondo can effectively improve metabolic syndrome, as evidenced by decreased body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), and triglyceride (TG) levels and increased high-density lipoprotein cholesterol (HDL-C) level. Taekwondo had the greatest effect on quinquagenarian women with abnormal levels of metabolic syndrome indicators. To maximize the intervention effect of taekwondo on metabolic syndrome, an exercise prescription of high-intensity poomsae, kick, and taekwondo gymnastics performed in 40–50 min sessions, three times weekly for 12 weeks is recommended.
Examining bedtime procrastination, study engagement, and studyholism in undergraduate students, and their association with insomnia
Authors: Alshammari Tahani K. , Rogowska Aleksandra M. , Basharahil Raghad F. , Alomar Sumayyah F. , Alseraye Sarah S. , Al Juffali Lobna A. , Alrasheed Nouf M. , Alshammari Musaad A. 
Published: January 2023

IntroductionCompulsive overstudying, known as studyholism, is an emerging behavioral addiction. In this study, we examine the prevalence of, and the relationships between, insomnia, study engagement, studyholism, bedtime procrastination among undergraduate students.MethodsThe Studyholism (SI-10), Athens Insomnia (AIS), and bedtime procrastination scales were administered to a convenience sample of 495 university students.ResultsOur findings indicate that the prevalence of insomnia was 75.31%, high studyholism was found in 15.31% of the sample, and increased study engagement was detected in 16.94%. Gender differences analysis revealed that females reported higher studyholism and bedtime procrastination than males. Fifth-year students had higher levels of studyholism than internship (p &lt; 0.001), first-year (p &lt; 0.01), and sixth-year students (p &lt; 0.05). Insomnia was positively related to studyholism and bedtime procrastination. Furthermore, insomnia can be positively predicted by studyholism and bedtime procrastination. Participants with a medium level of studyholism were twice as likely to experience insomnia as those with a low level. Studyholics were six times more susceptible to insomnia than students with low studyholism levels. Compared to individuals with low bedtime procrastination levels, those with medium and high bedtime procrastination were twice as likely to report insomnia.ConclusionOur study highlights the interplay between insomnia, studyholism, and bedtime procrastination. Further, the findings indicate the need to increase awareness of insomnia.
Safety, effectiveness and hesitancy of COVID-19 vaccination in children: A cross-sectional study in Pakistan
Authors: Zaufishan Zaufishan , Usman Muhammad , Fishan Mumtaz Khandah , Bilal Rabiea , Arshad Alina , Khan Humaira Majeed 
Published: January 2023

BackgroundThe elevated risk of serious complications like myocarditis and pericarditis after COVID-19 vaccination, especially in adolescent has been reported in some instances that need to be tested in regional populations and different ethnicity groups. The purpose of the study was to evaluate the side effects, hesitancy, and effectiveness outcomes following COVID-19 vaccination among children in Pakistan.MethodsThe study was planned using a cross-sectional design and data from Children and Adolescents (CA) was collected through a convenient sampling method using a validated questionnaire between February to July 2022. A total of 1,108 CA between the age of 12–18 years who received one or two doses of vaccine were selected and data were collected through direct interviews with respondents.ResultsThe results showed that among 99.8% of respondents who received the Pfizer COVID-19 vaccine, 72.3% of respondents were partially vaccinated (with one dose) while 27.7% were fully vaccinated (with two doses). COVID vaccination regime had a favorable safety profile in children as compared to adults. Vaccine hesitancy in children was reported to be 52.4% and the most common reasons for hesitance were the assumption that the vaccine is not safe (23.7%), the vaccine is not required (19.6%) and the vaccine is not effective (10.4%). The reported side effects were mainly mild (88.5%) followed by moderate (10.6%) and only 0.8% were of severe intensity. Post-vaccination local side effects of mild intensity were common with an onset of an average of 24 h (68%) and a duration of 2–3 days (60.6%). The reported side effects were significantly associated with gender (p = 0.00) while age had no significant effect on the occurrence of side effects. Overall, the vaccine was well tolerated by children and adolescents and was effective in preventing the reoccurrence of COVID-19 infection in 99.9% of participants.ConclusionCOVID-19 vaccine by Pfizer approved by the FDA for use in CA 12–18 years of age was well tolerated with a good safety profile and no serious adverse drug reactions were reported. The vaccine side effects were mild (88.5%) and lasted for an average of 2–3 days only (60.4%). The vaccine was effective in safeguarding Children against COVID-19 infection.
PENGARUH TINGKAT FINANCIAL LITERACY, TINGKAT PENDAPATAN DAN PERILAKU INVESTOR TERHADAP KEPUTUSAN INVESTASI INDIVIDU
Authors: Nuramelia Sulis , Rahayu Sri 
Published: January 2023

Pasar modal memegang peranan penting di zaman perekonomian modern sebagai sumber utama dalam penyediaan modal industri maupun komersial. Hal ini ditunjukkan dengan kenaikan jumlah investor berdasarkan data Kustodian Sentral Efek Indonesia (KSEI) 2021. Penelitian ini bertujuan untuk mengetahui Pengaruh Tingkat Literasi Keuangan, Tingkat Pendapatan dan Perilaku Investor Terhadap Keputusan Investasi Individu (Studi Empiris Terhadap Calon Investor Di Beberapa Daerah Di Indonesia). Teknik pengambilan sampel data melalui penyebaran kuesioner online kepada responden dengan menggunakan metode purposive sampling. Populasi penelitian adalah calon investor berusia 20-60 tahun di Papua, Maluku, Sulawesi, Jawa, Bali, Kalimantan dan Sumatera. Sebanyak 119 calon investor dijadikan sampel dalam penelitian ini. Analisis data yang digunakan adalah analisis regresi linier berganda, diuji menggunakan program Statistical Package For The Social Science (SPSS) versi 23 dan Microsoft Excel 2010. Berdasarkan hasil penelitian dapat disimpulkan bahwa tingkat literasi keuangan dan perilaku investor berpengaruh positif dan signifikan terhadap keputusan investasi individu, sedangkan tingkat pendapatan tidak berpengaruh terhadap keputusan investasi. Kata kunci: Tingkat Literasi Keuangan; Tingkat Pendapatan; Perilaku Investor; Keputusan Investasi Individu
The Contemporary Landscape and Future Directions of Intratumoral Immunotherapy
Authors: Brito-Orama Sebastian , Sheth Rahul A. 
Published: January 2023

ABSTRACT
Systemically administered immunotherapies have revolutionized the care of patients with cancer; however, for many cancer types, most patients do not exhibit objective responses. Intratumoral immunotherapy is a burgeoning strategy that is designed to boost the effectiveness of cancer immunotherapies across the spectrum of malignancies. By locally administering immune-activating therapies into the tumor itself, immunosuppressive barriers in the tumor microenvironment can be broken. Moreover, therapies too potent for systemic delivery can be safely administered to target location to maximize efficacy and minimize toxicity. In order for these therapies to be effective, though, they must be effectively delivered into the target tumor lesion. In this review, we summarize the current landscape of intratumoral immunotherapies and highlight key concepts that influence intratumoral delivery, and by extension, efficacy. We also provide an overview of the breadth and depth of approved minimally invasive delivery devices that can be considered to improve delivery of intratumoral therapies.
Dampak Penggunaan Handphone Terhadap Interaksi Sosial Remaja Studi Kasus Siswa Kelas IX SMPN 12 Poleang Barat
Authors: Ramang Ramang 
Published: January 2023

Penelitian ini bertujuan untuk mengetahui dampak dari penggunaan handphone terhadap interaksi sosial remaja, studi kasus siswa kelas IX SMPN 12 Poleang Barat. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan metode studi kasus. Hasil penelitian menunjukkan bahwa intensitas penggunaan handphone tinggi mencapai 3-7 jam perhari. WhatsApp, tiktok dan facebook merupakan tiga aplikasi yang paling sering diakses oleh siswa. Penggunaan ini memberikan dampak positif seperti mendapatkan pengetahuan luas, mempermudah komunikasi dan melatih kreativitas anak. Akan tetapi, penggunaan tanpa adanya kontrol dari orangtua memberikan dampak negatif diantaranya ancaman pornoaksi akibat mengikuti konten yang sedang viral, membuat atau sekadar membagikan gambar yang tidak pantas di grup-grup whatsApp kelas, menjadikan remaja lebih individualis, menjadikan hubungan interaksi sosial yang tercipta baik antar teman sebaya, hingga guru dan orang tua cenderung kurang sopan, dan membuat remaja kurang peka terhadap lingkungan sekitar
Pendekatan Konsep Merdeka Belajar Dalam Pembelajaran Seni Tari Di Era Industri 4.0 Untuk Mewujudkan Profil Pelajar Pancasila
Authors: Nawanti Rita Dwi 
Published: January 2023

Industri 4.0 adalah perkembangan zaman terkini berkaitan dengan otomasi dan pertukaran data teknologi pabrik. Agar dapat mengikuti zaman, kemampuan dan karakter dari siswa digiring mengikuti visi misi dari sebuah negara sekarang yakni mengejar ketertinggalan serta dapat setara dengan negara- negara maju lainnya. Dalam Kabinet Indonesia Maju, Nadiem Makarim; mentri pendidikan dan kebudayaan RI menggagas konsep pendidikan Merdeka Belajar dengan menekankan 4 aspek perubahan yakni USBN, UN, RPP dan Zonasi. Penekanan ini membuat pergeseran pendekatan pembelajaran khususnya Matapelajaran Seni Budaya (Seni Tari). Tujuan penelitian ini untuk mengetahui tingkat efektifitas konsep Merdeka Belajar terhadap pembelajaran Seni Tari di era industri 4.0. Menggunakan kajian teoritis pada konsep Merdeka Belajar dan hubungannya dengan tujuan pendidikan Negara Indonesia. Didapatkan konsep Merdeka Belajar sangatlah efektif dan fleksibel jika diterapkan dengan baik. Siswa dituntut untuk lebih aktif dan inovatif dalam mengolah ilmu serta pengetahuannya sehingga peran guru tidak hanya sebagai informan, namun lebih pada fasilitator sekaligus motivator dalam pembelajaran. Pondasi keaktifan siswa ditanamkan sejak sekolah dasar sebagai karakter yang akan mereka bawa dijenjang berikutnya. Kemajuan teknologi pada era Industri 4.0 juga mendukung variasi media pembelajaran yang lebih kompleks dan menarik dalam belajar Seni Tari Kesimpulannya konsep Merdeka Belajar yang didukung kemajuan teknologi era Industri 4.0 sangat efektif dalam pembelajaran seni Tari sehingga sesuai dengan tujuan Ki Hajar Dewantara, manusia pembelajar bisa “mangaju- aju salira, mangaju- aju bangsa, mangaju- aju manungsa” (membahagiakan diri, membahagiakan bangsa, membahagiakan kemanusiaan).
Tinjauan Kelengkapan Laporan Operasi Sectio Caesarea Di Rsud Kembangan 2022
Authors: Hidayat Adil , Widjaja Lily , Rosmala Dewi Deasy , Fannya Puteri 
Published: January 2023

Latar Belakang : Laporan Operasi merupakan catatan dokter terkait langkah langkah yang dilakukan saat pembedahan pasien. Laporan operasi harus segera dibuat setelah pembedahan dan dimasukkan dalam rekam kesehatan.
Tujuan : Tujuan dari penelitian ini adalah mengetahui kelengkapan pengisian laporan operasi pasien operasi caesar di RSUD Kembangan.
Metode : Metode penelitian yang dilakukan adalah metode deskriptif dengan analisis kuantitatif, untuk menggambarkan kelengkapan pengisian laporan operasi di RSUD Kembangan.
Hasil : Berdasarkan hasil penelitian mengenai Standar Prosedur Operasional pengisian lembar laporan operasi caesar di RSUD Kembangan Jakarta sudah ada, dimana sudah terdapat Standar Prosedur Operasional (SPO) yang mengatur tentang pengisian laporan operasi di RSUD Kembangan tetapi belum semua prosedur terlaksana, 2 point prosedur yang belum terlaksana dimana belum adanya buku catatan yang mencatat laporan operasi yang belum diisi dan pengisian laporan operasi masih dilaksanakan di ruang rawat inap, belum tersedianya buku catatan yang mencatat laporan operasi yang belum diisi. Hasil analisis kuantitatif dari 79 laporan operasi didapatkan kelengkapannya dengan persentase 96,3%.
Kesimpulan: Dampak dari ketidaklengkapan laporan operasi yaitu ada beberapa berkas yang tidak lengkap yang tidak dapat dipakai sebagai barang bukti yang sah bila dibutuhkan dipengadilan, menggangu proses keberlanjutan proses pengobatan, bagi pasien bpjs klaim menjadi terhambat, membuat proses kelanjutan pengobatan terganggu karna riwayat pengobatan pasien tidak lengkap, tidak lengkapnya laporan operasi juga berpengeraruh terhadap akreditasi rumah sakit.