bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neighborhood factors and triple negative breast cancer: The role of cumulative exposure to area‐level risk factors
Authors: Siegel Scott D. , Brooks Madeline M. , Berman Jesse D. , Lynch Shannon M. , Sims‐Mourtada Jennifer , Schug Zachary T. , Curriero Frank C. 
Published: March 2023

AbstractBackgroundDespite similar incidence rates among Black and White women, breast cancer mortality rates are 40% higher among Black women. More than half of the racial difference in breast cancer mortality can be attributed to triple negative breast cancer (TNBC), an aggressive subtype of invasive breast cancer that disproportionately affects Black women. Recent research has implicated neighborhood conditions in the etiology of TNBC. This study investigated the relationship between cumulative neighborhood‐level exposures and TNBC risk.MethodsThis single‐institution retrospective study was conducted on a cohort of 3316 breast cancer cases from New Castle County, Delaware (from 2012 to 2020), an area of the country with elevated TNBC rates. Cases were stratified into TNBC and “Non‐TNBC” diagnosis and geocoded by residential address. Neighborhood exposures included census tract‐level measures of unhealthy alcohol use, metabolic dysfunction, breastfeeding, and environmental hazards. An overall cumulative risk score was calculated based on tract‐level exposures.ResultsUnivariate analyses showed each tract‐level exposure was associated with greater TNBC odds. In multivariate analyses that controlled for patient‐level race and age, tract‐level exposures were not associated with TNBC odds. However, in a second multivariate model that included patient‐level variables and considered tract‐level risk factors as a cumulative exposure risk score, each one unit increase in cumulative exposure was significantly associated with a 10% increase in TNBC odds. Higher cumulative exposure risk scores were found in census tracts with relatively high proportions of Black residents.ConclusionsCumulative exposure to neighborhood‐level risk factors that disproportionately affect Black communities was associated with greater TNBC risk.
Raw or roasted Brosimum alicastrum seed powder as a nutritional ingredient in composite sugar‐snap cookies
Authors: Carter Chad T. , Northcutt Julie K. 
Published: March 2023

AbstractBackground and ObjectivesBrosimum alicastrum seeds have been a common indigenous food source from southern Mexico to Bolivia for centuries. Yet, information on how roasting affects the nutrition of baked goods made from this seed powder is lacking. A study was conducted to determine nutritional properties of raw and roasted B. alicastrum seeds and sugar snap cookies made from composite flour with equal quantities of wheat and B. alicastrum seed.FindingsUsing a 50% composite blend of raw or roasted B. alicastrum seed powder produced cookies with higher moisture, fat, carbohydrate, and ash than cookies made from 100% all‐purpose wheat flour. Roasting seeds increased total carotenoid content of seed powder but reduced levels of five of the nine essential amino acids.ConclusionB. alicastrum seed powder can be used at a 50% level composite blend with wheat to increase fat, carbohydrate, total carotenoids, calcium, copper, magnesium, phosphorus, potassium, zinc, and sodium levels in cookies without compromising fiber, vitamin C, iron, or manganese content.Significance and NoveltyRaw or roasted B. alicastrum seed powder can be used as a composite blend with wheat to enhance or maintain the nutritional composition of baked goods, such as sugar snap cookies.
A novel Block Bi‐diagonalization based pre‐coding scheme for bit error reduction in mutiple input multiple output‐orthogonal frequency division multiplexing
Authors: Paul Prajit , Roy Bappadittya , Bhattacharjee Anup Kumar 
Published: March 2023

SummaryThe MIMO‐OFDM increases spectral efficiency without the use of channel state information (CSI). However, the bit error rate (BER) in the MIMO‐OFDM model increases dramatically due to the increase in nonlinear distortion in the power amplifier (PA). In this research, a novel pre‐coder integrated MIMO‐OFDM technology is designed for effective BER reduction, and its performance is analyzed. The discrete wavelet‐based OFDM system is one of the key ideas to present good orthogonal by emphasizing orthogonal wavelets. It helps to mitigate inter‐symbol interference (ISI) and noise within the channel by extending the bandwidth (BW) compared to conventional OFDM systems. But, DWT‐OFDM highly suffered due to downsampling, which degrades system efficiency. To overcome this, a redundant discrete wavelet transform (RDWT) is proposed in this article to enhance spectral efficiency. For modulation, 16‐bit quadrature amplitude modulation (QAM) is introduced in this work. In addition to this, a block bi‐diagonalization (BBD) pre‐coder technique is proposed to mitigate unwanted noise and interference in the MIMO‐OFDM system. The performance measures such as ergodic sum capacity, BER, throughput, average jitter noise power, mean square error (MSE), and power consumption are analyzed using the MATLAB platform. The proposed method obtains the ergodic sum capacity of 6.25 bps/Hz, a BER of 0.021, a throughput of 95.2%, MSE of −0.47, and a power consumption of 1.15 μW. The simulative results prove the efficacy of the proposed method.
A Plio‐Pleistocene eustatic and storm‐controlled mixed carbonate–siliciclastic marine ramp deposit in south‐west Florida: An example of sediment homogenisation with maintenance of carbonate‐producing organisms
Authors: Missimer Thomas M. , Hegy Michael 
Published: March 2023

AbstractMixed siliciclastic and carbonate sediments are common in the stratigraphic record, but fully homogenised mixes are not. Many occurrences of mixed sediment sequences are dominated by end‐members with stacking of ‘nearly pure’ lithfacies (e.g. cyclothems containing alternating sandstone, limestone and coal units). The Plio‐Pleistocene sediments within south‐west Florida provide insights into the occurrence of fully homogenised siliciclastic/carbonate deposits. In all defined environments from lagoon to supratidal to inner tidal to beach to offshore to coral reef, quartz sand coexists with carbonates. Perhaps the key feature that allowed full homogenisation of the sediments within all facies and subfacies was the relatively shallow water (<10 m), which facilitated mixing during low‐order eustatic sea‐level events and storms. However, four factors contributed to the full homogenisation of the sediment types without termination or inhibition of carbonate organism growth. These factors are (1) the shallow water allowing wave‐driven sediment transport (all environments within the wave orbital depth), (2) close proximity and perhaps irregular nature of the depositional environment boundaries, (3) low influx rate of quartz sand via longshore transport, and (4) the lack of significant terrigenous mud transport into the system. Mixing processes at the large‐scale included movement of sediments from one depositional environment to another during storms, mixing along facies boundaries, and in situ mixing within autochthonous and parautochthonous mollusc death assemblages. At the smaller scale, mixing occurred by bioturbation and diagenetic dissolution of carbonate skeletal grains during minor high sea‐level stands.
Mortality in anorexia nervosa and bulimia nervosa: A population‐based cohort study in Taiwan, 2002–2017
Authors: Tseng Mei‐Chih Meg , Chien Li‐Nien , Tu Chao‐Ying , Liu Hung‐Yi 
Published: March 2023

AbstractObjectiveTo investigate natural‐ and unnatural‐cause mortality at different follow‐up time points in Taiwanese patients with anorexia nervosa (AN) and bulimia nervosa (BN).MethodIn this longitudinal cohort study, 330,393 patients, including 2143 patients with AN, 13,590 with BN, and 20 times as many respective non‐AN and non‐BN patients, were followed up for 16 years. We performed conditional Cox regression survival analysis to examine the risk of mortality in the AN and BN groups relative to the comparison group.ResultsA total of 1242 patients died, including 101 and 343 patients with AN and BN, respectively. Mortality rates for AN and BN were 5.42 and 2.90 deaths per 1000 person‐years, respectively. Compared with the non‐AN group, the AN group had a significantly higher risk of both natural‐ and unnatural‐cause mortality, and the BN group had a significantly higher risk of unnatural‐cause mortality. Suicide was the most common cause of death, and suicide risk was significantly higher in both the AN and BN groups. All‐cause mortality risk was the highest at the beginning of follow‐up and markedly declined in the AN group. In the BN group, all‐cause mortality risk was lower but stable at follow‐up. The risk of unnatural‐cause mortality remained high throughout the follow‐up period for both the groups.ConclusionsEarly detection and treatment for associated physical problems in patients with AN are crucial. Regular monitoring for unnatural‐cause mortality events (mainly suicide) in AN and BN over time is also crucial.Public SignificanceAN had a significantly higher risk of both natural‐ and unnatural‐cause mortality and BN had a significantly higher risk of death from unnatural causes. All‐cause mortality risk was highest at the beginning of follow‐up in AN, but unnatural‐cause mortality risk remained high throughout the follow‐up period for both groups. Our findings imply that early detection and treatment in AN and regular monitoring for unnatural‐cause mortality events in AN and BN are crucial.
Environmental DNA survey of the Winter Salmonosphere in the Gulf of Alaska
Authors: Deeg Christoph M. , Li Shaorong , Esenkulova Svetlana , Hunt Brian P. V. , Schulze Angela D. , Miller Kristina M. 
Published: March 2023

AbstractPacific salmon (Oncorhynchus spp.) are a foundation species around the north Pacific, yet many wild populations have experienced steep declines over the last decades associated with decreased marine survival. Due to limited sampling, our understanding of the dynamic North Pacific Ocean ecosystem remains poor and factors impacting marine survival of salmon remain largely unknown, specifically in the winter when salmon face limited resources. Here, we present a late winter ecosystem‐wide environmental DNA (eDNA) survey performed in 2019 and 2020 in the Gulf of Alaska. Our eDNA data refines the ocean distribution and relative abundance of Pacific salmon, as well as their prey such as copepods. Vertical diurnal migrators like myctophids and squid that are prey and/or competitors of salmon and represent the bulk of the open ocean biomass in the Gulf of Alaska. We detected these species irrespective of time of day in the eDNA data, resolving the nighttime bias associated with trawl catches. Furthermore, eDNA uncovered cryptic predators of salmon such as salmon sharks (Lamna ditropis) and beaked whales (Ziphiidae) not evident from catch or observer data. Open‐ocean communities of the central Gulf of Alaska were characterized by low species richness in contrast to hotspots of biological activity associated with oceanographic features such as eddies and the continental shelf. Network analysis revealed the ecological interactions that salmon navigate in the open‐ocean ecosystem by identifying key prey species, competitors, and predators and revealed the negative impact of the northern sea nettle (Chrysaora melanaster) on salmon that was associated with a marine heatwave in 2019. Finally, we highlight the utility of eDNA for open ocean ecosystem research and provide recommendations for further surveys. This dataset, complementing traditional survey methods, illustrates the winter salmonosphere in the North Pacific Ocean at improved resolution and provides a baseline for future research.
Privacy‐preserving authentication scheme for digital twin‐enabled autonomous vehicle environments
Authors: Chen Chien‐Ming , Miao Qingkai , Kumar Sachin , Wu Tsu‐Yang 
Published: March 2023

AbstractCurrently, the automotive industry has entered a period of considerable advancement, shifting towards the development of safe, comfortable, and connected autonomous vehicles. However, the need for real‐time sensing, computation, and communication may lead to information overflow in autonomous cars, resulting in data redundancy. Furthermore, anticipating traffic conditions beyond a vehicle's field of view can be quite difficult owing to the restricted range of communication systems. To solve these problems, digital twin systems have been developed for autonomous driving environments. Because autonomous vehicles are driven on open public road networks, this function may jeopardize vehicles, user‐identifying information, and sensitive data. Hence, an authentication scheme that can be deployed in digital‐twin‐enabled autonomous vehicle environments is needed. In this study, we propose a privacy‐preserving authentication mechanism. To establish the security of the proposed method, we performed a formal security analysis based on the real‐or‐random model. Furthermore, we assessed the performance of the proposed scheme, and our results demonstrate that it can reduce calculation and transmission costs.
Resource allocation and user assignment schemes in cellular supported industrial IoT networks
Authors: Ferdouse Lilatul , Khwaja Ahmed Shaharyar , Anpalagan Alagan , Stimpson Brad , Arad Ali , Woungang Isaac 
Published: March 2023

AbstractIndustrial Internet of Things (IIoT) deployment underlying cellular networks has been drawing increasing attention in recent years. In this work, we consider group based resource allocation for industrial IoT networks where cellular‐IoT (C‐IoT) devices support uplink transmission for multiple IoT groups/clusters. The joint group and subcarrier optimization problem is formulated for maximizing the cell/group throughput under the optimal group member selection, subcarrier and minimum data rate constraints. Depending on the interference information, the interference aware group allocation (IA‐GA) is proposed to find the cellular user and cellular‐IoT device grouping for each subcarrier. However, to achieve the maximizing the cell/group throughput, another iterative algorithm, namely genetic algorithm based group allocation (GA‐GA) method is proposed, which provides an optimal solution for the user grouping in the most of the cases where an iterative technique is used for the sub‐carrier allocation. Simulations results show that the proposed IA‐GA and GA‐GA methods provide enhanced cell throughput gain and accessibility of the C‐IoTs.
Origin and evolution of vanadium‐rich oxide and titanite phases in lamprophyre and mafic dykes from the Nuapada diamondiferous Lamproite field, BastarCraton‐EasternGhats Mobile belt contact, India: Metallogenic and geodynamic implications
Authors: Pandey Rohit , Singh Mahendra Kumar , Rao N. V. Chalapathi 
Published: March 2023

Transitional boundaries of the craton and mobile belt mark diverse and long‐term tectono‐thermal events like hot and cold lithospheric contact, back‐arc‐type subduction, and also constitute a favourable locale for metallogeny. The exact nature and origin of such metallogenic enrichment in the lithospheric mantle source beneath contact zones are still uncertain. The contact of Bastar Craton and the Eastern Ghat Mobile Belt (EGMB), India, provides an ideal geological setup to study the metallogenic enrichment processes. In this study, we present a detailed petrographic and mineralogical investigation of various iron oxide phases and titanites in spatially and temporally distinct lamprophyre and mafic dykes from the diamondiferous Nuapada Lamproite Field (NLF) at the contact between Bastar Craton and EGMB. Diverse textural assemblages of oxides, namely, trellis, sandwich‐type exsolutions and reaction–replacement, are widespread. Ilmenites, magnetites and titanites from the mafic dykes as well as lamprophyre exhibit an anomalous enrichment of vanadium (V2O3up to 3.7 wt%), whereas ilmenites are also characterized by their elevated manganese content (MnO up to 3.8 wt%). Mineral chemistry‐based plots and thermo‐oximetric studies suggest the magmatic origin of iron oxides belonging to the Fe–Ti–V‐type ore in which partitioning and sequestration of the elements were controlled by differential crystallization, exsolution and fractionation rather than any imprints of contamination. Multiphase sequestration of vanadium as well as manganese in lamprophyre and mafic dykes, separated in space as well in relative depths of origin, signifies the presence of a fertile mantle. The role of subduction‐derived metasomatized fluids as a causative factor of vanadium metallogeny in this domain is evaluated. Low‐Mg and high‐Mn ilmenites of this study are consistent with the reported occurrences of diamonds from the NLF and adjoining areas of the Bastar Craton.
Depth‐resolved attenuation mapping of the human ovary and fallopian tube using optical coherence tomography
Authors: Li Shuying , Luo Hongbo , Kou Sitai , Hagemann Ian S. , Zhu Quing 
Published: March 2023

AbstractDue to the lack of reliable early‐diagnostic tools, most ovarian cancers are diagnosed at late stages. Although optical coherence tomography (OCT) has shown promise for identifying diseased ovaries and fallopian tubes at an earlier stage, previous studies either did not provide quantitative scattering mapping or simply used Beer's law to fit the scattering coefficients of each A‐line. In this paper, we calculated the pixel‐wise attenuation coefficients of ovaries and fallopian tubes in OCT images. Data from 73 freshly excised human ovaries and fallopian tubes from 36 patients have shown that statistical features are statistically different between cancerous ovaries, infundibula, and fimbriae and normal ones.
Structure and stability of the sH binary hydrate cavity and host‐guest versus guest‐guest interactions therein: A DFT approach
Authors: Mondal Sukanta , Jana Gourhari , Srivastava Hemant K. , Sastry Garikapati N. , Chattaraj Pratim Kumar 
Published: March 2023

AbstractThe intrinsic ability of clathrate hydrates to encage gaseous molecules is explored. Encapsulation ability depends on the cavity size and the type of guest gaseous species in addition to the physical parameters, temperature and pressure. Here we have reported the structure, stability and nature of interaction in dissimilar guest occupied sH hydrate cavity. Diatomic gas molecules and small polyatomic hydrocarbons are considered as guests. The irregular icosahedron (51268) cavity of sH hydrate is the host. Different thermodynamic parameters for the guest molecules encapsulation were calculated using three different hybrid DFT functionals, B3LYP, M05‐2X, M06, and moreover using dispersion correction (PBE0‐D3). With the consideration of large H‐bonded systems the 6‐31G* and cc‐pVTZ basis sets were used for two set of computations. To disclose the nature of interaction between the host‐guest systems as well as the interaction between the guest molecules inside the host the non‐covalent interaction (NCI) indices and energy decomposition analysis (EDA) were done. Impact of host‐guest and guest‐guest interactions are discussed.
Partially hydrolyzed guar gum upregulates heat shock protein 27 in intestinal Caco‐2 cells and mouse intestine viamTOR and ERK signaling
Authors: Rini Dina Mustika , Yamamoto Yoshinari , Suzuki Takuya 
Published: March 2023

AbstractBACKGROUNDThe intestinal epithelium acts as a barrier against harmful luminal materials, thus preventing intestinal diseases and maintaining intestinal health. Heat shock protein 27 (HSP27) promotes intestinal epithelial integrity under both physiological and stressed conditions. The effects of partially hydrolyzed guar gum (PHGG) on HSP27 expression in intestinal Caco‐2 cells and mouse intestines were investigated.RESULTSThe present study showed that PHGG upregulated HSP27 expression in Caco‐2 cells without upregulating Hspb1, the gene encoding HSP27. Feeding PHGG increased HSP25 expression in epithelial cells of the small intestine of mice. Inhibition of protein translation using cycloheximide suppressed PHGG‐mediated HSP27 expression, indicating that PHGG upregulated HSP27 via translational modulation. Signaling inhibition of the mechanistic target of rapamycin (mTOR) and phosphatidyl 3‐inositol kinase reduced PHGG‐mediated HSP27 expression, whereas mitogen‐activated protein kinase kinase inhibition by U0126 increased HSP27 expression, irrespective of PHGG administration. PHGG increases mTOR phosphorylation and reduces extracellular signal‐regulated protein kinase (ERK) phosphorylation.CONCLUSIONPHGG‐mediated translation of HSP27 in intestinal Caco‐2 cells and mouse intestine via the mTOR and ERK signaling pathways may promote intestinal epithelial integrity. These findings help us better understand how dietary fibers regulate the physiological function of the intestines. © 2023 Society of Chemical Industry.
Assessing Obstetric Anal Sphincter Injuries
Authors: Zhao Baihua , Li Yinbo , Tang Yingchun , Guo Yuyang , Yang Yalin , Wen Lieming , Dietz Hans Peter 
Published: March 2023

ObjectivesTo explore the differences in assessing obstetric anal sphincter injuries (OASI) between transperineal ultrasound (TPUS) and endoanal ultrasound (EAUS) and test relationships between ultrasound findings and anal incontinence (AI) symptoms.MethodsA group of 196 women with a history of vaginal delivery was recruited. OASI was detected in a set of 5 slices by EAUS and 8 slices by TPUS. OASI grading was performed on TPUS rules and EAUS rules. A “significant sphincter defect” was diagnosed by TPUS and EAUS using “2/3 rules.” Symptoms of AI were determined using the St Mark's Incontinence Score (SMIS). Ultrasound findings were compared between the two methods and correlated with symptoms.ResultsOf 196 women, 29 (14.8%) suffered from AI with a mean SMIS of 12.1 ± 4.5, and 70 (35.7%) women with a mean age of 57 years had suspected OASI on imaging. Twenty‐one (10.7%) “significant defects” were diagnosed by TPUS and 24 (12.2%) by EAUS. OASI Grades on TPUS had good agreement with EAUS rules (k = 0.70, P < .001). Logistic regression analysis showed that OASI Grade on imaging and “significant sphincter defects” seen on both forms of imaging were associated with AI symptoms. The odds ratio was 46 and 38 for “significant defects” on TPUS and EAUS, and 14 and 7 for OASI 3b+ on TPUS and EAUS in predicting AI, respectively.Conclusions“Significant defects” diagnosed by EAUS or TPUS and OASI Grade 3b+ predict AI symptoms. The diagnostic performance of endoanal and exoanal ultrasound (EAUS and TPUS) appear to be very similar.
Soil fertility thresholds driven by sand content indicate drylands degradation phases on the Tibetan Plateau
Authors: Cai Qin‐Yue , Wang Xiang‐Sheng , Ma Tao , Ye Jian‐Sheng 
Published: March 2023

AbstractUnderstanding the process of dryland degradation is crucial to combating desertification and maintaining land sustainability. To identify important indicators of dryland degradation, we conducted a field survey of 46 drylands spanning an aridity gradient across the Tibetan Plateau. Our random forest model suggested that soil sand content was the most important predictor of variation in soil fertility (carbon, nitrogen, and phosphorus). Most soil fertility showed a nonlinear and abrupt decline with increasing soil sand content, and displayed three sequential thresholds. First, soil organic carbon sharply decreased beyond a soil sand content threshold of 47%. Second, exceeding a subsequent threshold of 70%, the total nitrogen and light fraction carbon declined dramatically with increasing soil sand content. Finally, soil heavy fraction carbon, inorganic carbon, and total carbon were drastically reduced when the soil sand content exceeded 80%. The three soil fertility thresholds along the gradient of the soil sand content indicated a sequence of dryland degradation phases. Our findings provide an approach for detecting the severity of dryland degradation and suggest vulnerable areas of degradation on the Tibetan Plateau.