bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outpatient pediatric cardiology consultations in a tertiary academic hospital
Authors: Alturkestani Razan N , Bahafzalla Rafeef A. , Safhi Maha A. , Hasanain Anhar M. , Bahaidarah Saud A. 
Published: July 2023

ABSTRACT

Objectives:
Cardiac diseases in the pediatric population can be congenital or acquired. If the diagnosis and treatment are early, the chance for survival increases. Thus, this study aimed to determine the indications for pediatric cardiology consultations in a single tertiary hospital in Jeddah, Saudi Arabia.

Materials and Methods:
This study was conducted in 2020–2021 at a tertiary center in Jeddah, Saudi Arabia. Patients younger than 14 years of age who were referred by outpatient clinics or those who presented to the emergency department and needed outpatient cardiac evaluation were included in this study. Inpatient referrals were excluded. The Statistical Package for the Social Sciences version 21 was used for statistical analyses.

Results:
A total of 416 referred patients were included in this study. New patients accounted for 74% of the referrals, while known patients accounted for 26%. The median age was 2.728 years, with 56.3% being male participants. The three most common reasons for referral were: evaluation of cardiac function (21.6%), follow-up evaluation of fetal/neonatal diagnosis (19.5%), and heart murmurs (16.8%).

Conclusion:
Most of the referrals were new patients. Of those who underwent echocardiography, 48.2% had abnormal results. We recommend further studies to help guide the direction of the residents’ education and to provide better patient healthcare services.
بعض الدراسات الجراحية على الفتاقات في الأغنام و الماعز
Authors: اكريم المهدى محمد , حجازي اشرف عبدالحميد 
Published: July 2023

تصاب الأغنام و الماعز بانواع عديدة من الفتاقات مثل السي والبطنى و الاربي و التي يعتمد تشخيصها غالبا على الاعراض الاكلينيكية وتاتى أهمية دراستها لما تسببه من خسائر اقتصادية ناجمة عن قلة الإنتاج و التكاثر بالإضافة الى بعض المشاكل الهضمية . في هذا البحث تمت دراسة 23 حالة اكلينيكية من الأغنام و الماعز المصابة بالفتق منها 17 حالة من الأغنام (9اناث و 8 ذكور ) و 6حالات ماعز ( 5 اناث وذكر واحد ) من سلالات مختلفة .تم في هذه الدراسة تحديد كل من العمر ، تاريخ المرض ، نوع الفتق ، حجم فتحة الفتق ، درجة الالتصاق ومحتويات الفتق .كما ركزت الدراسة على طرق التخدير و العلاج الدوائي والجراحي . وكانت نتائج البحث كالاتى محتويات الفتق تكون جزء من الثرب يتبعه الأمعاء ثم المنفحة و الكرش و الرحم الحامل .الفتق السري و الصنفي يحدث كثيرا في الحيوانات النى عمرها اقل من عام ولكن الفتق البطنى و الاربي يوجد بكثرة في الحيوانات الكبيرة . الالتصاق بين محتويات الفتق و الجدار الداخلى للفتق موجود في كل الحالات ولكنه يزيد بمرور الوقت على الإصابة وتم دراسة نوع الخيوط الجراحية والخياطات المستخدمة في اغلاق فتحة الفتق . ومن تلك الدراسة خلصنا الى ان : دراسة تاثير نوع الفتق وفترة حدوثه على نوع الخيط المستعمل في العملية الجراحية . دراسة حجم الفتق في نوع الخيط المستعمل .
Aspects of the development of hypothyroid cardiomyopathy associated with chronic systemic inflammation
Authors: Horodynska О.Yu. , Muravlova О.V. , Shaienko Z.О. , Dvornyk І.L. 
Published: July 2023

Background. Cardiovascular manifestations are rated first among the symptoms of hypothyroidism. Since the highest prevalence of both coronary heart disease (CHD) and hypothyroidism is observed in the age group over 50 years old, the problem of combination of these nosologies in older people is increasing. Aim of the study is to investigate the structural and functional state of the left ventricular myocardium in hypothyroidism and CHD associated with chronic systemic inflammation. Materials and methods. To reach the objectives of the study, a randomized controlled clinical trial has been conducted in parallel groups of patients with hypothyroidism, CHD and combination of both. To form the main group, a screening analysis of 556 medical histories of patients with hypothyroidism and CHD during the period of 2006–2015 has been made, which were selected for further study. Results. It has been found that myocardial hypertrophy develops in all groups of patients, a decrease in thyroid function leads to remodeling of the left ventricular myocardium with the development of eccentric hypertrophy and the progression of systolic heart failure in comorbidity. A direct correlation between reduced ejection fraction and elevated interleukin-8 level has been detected. Evaluation of the state of chronic systemic inflammation revealed a significant increase in the level of interleukin-8 in patients with coronary heart disease associated with hypothyroidism (7.66 ± 2.18 pg/ml; p < 0.05). This indicate that the persistence of pro-inflammatory state in patients with combined pathology is a negative prognostic factor for the development of cardiovascular complications. Conclusion. During echocardioscopy of patients with hypothyroidism, the impaired central hemodynamics can be determined by the indicators of the diastolic and systolic heart function. In patients with isolated hypothyroidism and in combination with coronary heart disease, thickening of the left ventricular myocardial walls is noted, which proves the specificity of changes in the heart geometry that leads to the development of eccentric hypertrophy. This can be considered as the marker of a “hypothyroid” heart whose severity can determine the severity of hypothyroidism. Activation of chronic systemic inflammation is more pronounced in conditions of comorbidity, with a negative prognostic effect on the state of the cardiovascular system.
Emerging Problem Evaluation of Hypocalcemia in Super Vasmol Hair Dye Poisoning Patients: Clinical Study in RIMS, Kadapa
Authors: Babu K. Leela Prasad , Kareemulla Shaik , Ramani M. , Nagamani L. , Abhishek B. , Bai K. Sravanthi 
Published: July 2023

Introduction: One of the most frequent method of suicide attempt in India is intentional super vasmol poisoning. If it is untreated, it leads to many complications such as, rhabdomyolysis, angioedema, acute kidney injury, and hypocalcemia. Of all above mentioned; hypocalcemia can cause pathologies of the neuromuscular, cardiovascular, and respiratory systems. Early detection and treatment of the issue can reduce the diseases and fatalities that are related to it.
Aim: This study aims to assess the incidence, clinical manifestations, and management of hypocalcemia in super vasmol poisoning patients.
Methods: A prospective observational study was undertaken on 50 super vasmol poisoning patients for about six months at the government general hospital, RIMS, Kadapa from November 2021 to April 2022. Only subjects who are willing to give their consent were included in the study. All trial participants were observed for the duration of their hospital stay to evaluate hypocalcemia.
Results: Out of the 50 subjects, 22 (44%) were male, 28 (56%) were female, and the majority (40%) were in between the age group of 21 to 30 years. 15 patients (30%) out of the 50 subjects were developed with hypocalcemia, particularly those who consumed more than 50 ml of super vasmol. We observed that 66.5% of subjects received parenteral calcium gluconate while 33.5% subjects received oral calcium carbonate.
Conclusion: Hypocalcemia is a hidden complication of super vasmol poisoning, and there is a need to raise awareness among the among medical professionals about the necessity of routinely checking serum calcium levels as well as public regarding the dangers of super vasmol.
Keywords: Super vasmol, Toxicity, Hypocalcemia, Hospitalization, Counselling.
Potential activity of Stevia rebaudiana Bert. in Inhibiting Cyclooxygenase and Lipooxygenase Enzymes as Anti-inflammatory Candidates: A Molecular Docking Study and ADMET Prediction
Authors: Adelia Meida , Setiawansyah Arif , Sitindaon Rina SE 
Published: July 2023

Stevia rebaudiana Bert. is one of the plants that has been traditionally used to treat inflammation. Numerous articles have reported scientific evidence of the anti-inflammatory activity of Stevia rebaudiana Bert. However, research regarding the bioactive contributing to its anti-inflammatory activity has never been discovered. This study was implemented to identify the molecules regulating the anti-inflammatory activity of Stevia rebaudiana Bert. and assess their pharmacokinetics and toxicological profile. The potent phytochemical derived from Stevia rebaudiana Bert. was screened via a molecular docking approach using autodock 4.2 assisted by ADT interface to COX-1, COX-2, and 5-LOX. The ADMET assessment was undertaken via biosig pkCSM web server. Molecular docking results revealed that β-sitosterol, campesterol, and stigmasterol exhibited high affinity to COX-1, COX-2, and 5-LOX with free energy of binding value of -11.12, -11.43, and -10.62 kcal/mol for COX-1, -11.45, -11.34, and -11.84 kcal/mol for COX-2, and -5.95, -11.34, and -9.08 kcal/mol for 5-LOX, respectively. The ADMET prediction also indicated those bioactive have an excellent pharmacokinetics and toxicity profile. Therefore, β-sitosterol, campesterol, and stigmasterol can be considered to be developed as anti-inflammation agents. However, further research regarding their anti-inflammatory activities including in vitro and in vivo assays is necessary to be implemented.
Keywords: anti-inflammation, molecular docking, Stevia rebaudiana Bert.
Sociological Study on Residents' Perception of Special Economic Zone Regarding the Consequent Change in the Area; A Case Study of District Faisalabad
Authors: Javaid Laraib , Kousar Noureen , Anjum Farkhana , Nida Nida , Anwar Maria , Javaid Umbreen 
Published: July 2023

CPEC is a hot topic among the entire world and its growth in the Islamic Republic of Pakistan has been fruitful. Special economic zones helped in encouraging foreign and domestic finances, employability, business, and financial stability resulting in infrastructural development; upgraded technology, human capital expansion and fiscal reforms for the host country. This investigation aimed to visualize the socio-economic effect on local people and the way how they perceive the special economic zone beneath the CPEC (China-Pakistan Economic Corridor) initiative. A quantitative research approach was adopted to achieve the goal of this research; to analyze these social and economic levels. The data was acquired through a well-structured interview schedule. The target population was the villagers living near the industrial zone, District Faisalabad. Tehsil Chak Jhumra was selected by using the purposive sampling technique due to the reason for declared Special Economic Zone. The purpose of this investigation was to look at the socio-economic impact of the special economic zone (district Faisalabad) on local people underneath the (China-Pakistan Economic Corridor) CPEC perspective. This study has filled the aperture and examined the direct socio-economic impact of the special economic zone for local citizens of Pakistan This study has drawn a true picture of the present scenario; to what extent Special Economic Zone has a direct impact on them and their positive or negative thinking over it.
Heart team consultations for patients with severe coronary artery disease or valvular heart disease in the era of the COVID-19 pandemic: a single-center experience
Authors: Jonik Szymon , Boszko Maria , Sztemberg Elena , Łepecki Dominik , Grodziński Bartłomiej , Mikusek-Pham Van Marcin , Marchel Michał , Kochman Janusz , Kuśmierczyk Mariusz , Opolski Grzegorz , Grabowski Marcin , Mazurek Tomasz 
Published: July 2023

IntroductionThe Heart Team (HT) as a group of experienced specialists is responsible for optimal decision-making for high-risk cardiac patients. The aim of this study was to investigate the impact of the COVID-19 pandemic on HT functioning.MethodsIn this retrospective, single-center study, we evaluated the cooperation of HT in terms of the frequency of meetings, the number of consulted patients, and the trends in choosing the optimal treatment strategies for complex individuals with severe coronary artery disease (CAD) or valvular heart disease (VHD) before and during the COVID-19 pandemic in Poland.ResultsFrom 2016 to May 2022, 301 HT meetings were held, and a total of 4,183 patients with severe CAD (2,060 patients) or severe VHD (2,123 patients) were presented. A significant decrease in the number of HT meetings and consulted patients (2019: 49 and 823 vs. 2020: 44 and 542 and 2021: 45 and 611, respectively, P &lt; 0.001) as well as changes in treatment strategies—increase of conservative, reduction of invasive (2019: 16.7 and 51.9 patients/month vs. 2020: 20.4 and 24.8 patients/month and 2021:19.3 and 31.6 patients/month, respectively, P &lt; 0.001)—were demonstrated with the spread of the COVID-19 pandemic. As the pandemic slowly receded, the observed changes began to return to the pre-pandemic trends.ConclusionsThe COVID-19 pandemic resulted in a decrease in the number of HT meetings and consulted patients and significant reduction of invasive procedures in favor of conservative management. Further studies should be aimed to evaluate the long-term implications of this phenomenon.
Áldás vagy átok? A munka és a munkaerőpiac jövőjét meghatározó tényezők
Authors: Gödör Zsuzsanna 
Published: July 2023

A technikai technológiai innovációk, és a nyomukban meginduló fejlődés, rendszerint különböző formában és mértékben, de mindig is hatással volt a munka világára, a munkaerőpiaci folyamatokra, a munkát végző emberekre. Ezek a változások jelentős társadalmi hatásokkal járnak. Ezek egy része tartósnak bizonyul, más részük csak rövidtávon jelentkező, ezért átmeneti. A folyamatok egy része egyértelműen pozitív hatásokat eredményez: az új, tudás-intenzív iparágak megjelenése és megerősödése új esélyeket teremt a túlnépesedő társadalmak egyes problémáinak enyhítésére, és az emberi életminőség, az egyéni és társadalmi jóllét növelésére. Ugyanakkor a felgyorsuló technikai–technológiai fejlődés nyomán számtalan új, eddig ismeretlen kihívásnak kell megfelelnünk. A mostani változások sajátosságát leginkább azok korábban nem tapasztalt gyorsuló üteme, és sebessége jelenti. Mindez megnöveli a gazdasági döntések bizonytalanságát, ami egyértelmű munkapiaci hatásokat is eredményez. Azt ma már nem vitatják, hogy az információs technológiák elterjedésével meg kellett változnia a munka egyes jellemzőinek, és ennek nyomán a munkaerőhöz kapcsolódó foglalkoztatási formáknak is. A foglalkozási viszonyok folytonossá váló változása elengedhetetlenné tette az eddigi, munkavégzéssel kapcsolatos definíciók és magatartásformák átalakulását. A munka világának gyökeres átalakulását igényli és kikényszeríti az ipari forradalom küszöbön álló új periódusa. A tanulmány célja annak bemutatása, melyek a munka és a munkaerőpiac jövőbeni dimenziói, továbbá azok meghatározó és befolyásoló tényezői. Ennek keretében a munka és a munkaerőpiaci viszonyok ezzel kapcsolatos változásával, a változások társadalmi-gazdasági kiváltó okaival és várható következményeivel foglalkozik. Bemutatja a munka átalakuló világának hagyományostól eltérő új meghatározó tendenciáit, a fő érintettek, a munkavállalók és a munkaadók előtt álló kihívásokat.
Albert Ballin (English edition)
Authors: Gerhardt Johannes 
Published: July 2023

His was an unprecedented rise to the top: from the thirteenth child of a poor Jewish emigrant agent to the "sovereign of shipping" and "friend" of the Kaiser. It is hardly surprising that Alfred Ballin was one of the foremost figures of Wilhelmine Empire. From the beginning, he attracted attention at Hamburg-Amerikanische Packetfahrt-Aktien-Gesellschaft, known as Hapag for short. Under its manager Ballin, Hapag became the largest shipping line in the world.
From 1907 until his tragic death on November 9th 1918, Ballin belonged to the board of trustees of the Hamburg Scientific Fondation, to which he also contributed in a special way.
Ballin's biography sketches the unusual life of this man, who personified perhaps more than any of his comtemporaries the prominence and power of the second German Empire but at the same time also experienced its limits and weaknesses.
Emotional and cognitive states of geriatric patients during the COVID-19 pandemic – an observational study
Authors: Sadura-Sieklucka Teresa , Szczuka Joanna , Targowski Tomasz 
Published: July 2023

IntroductionThe authors of the study assessed the emotional and cognitive state of geriatric patients during the COVID-19 pandemic and tried to answer the question: were there any differences in this state in geriatric patients at different stages of the pandemic?Material and methodsThe study included 518 patients of 60 years old and above of the Department of Geriatrics in Warsaw. To collect data, the following tools of psychological measurement were applied: the Mini-Mental State Examination scale and Geriatric Depression Scale. In order to test the differences in the means between the groups, a Chi-square test (with Yates’s correction for continuity when the class size did not exceed 8 items) was used. For the comparison of the three groups, the Kruskal-Wallis (ANOVA) test was performed.ResultsIt was found that the majority of geriatric patients (73% of respondents) do not show symptoms of depressed mood. But there are statistically significant differences in the results of the patients’ cognitive state tests depending on the time of examination. Patients examined before the pandemic tended to demonstrate a better cognitive state than patients at the beginning of the pandemic and in its later stages. Nevertheless, there are no significant differences in the cognitive functioning of patients examined at the beginning and later in the pandemic.ConclusionsThe number of geriatric patients with symptoms of depression significantly increased when visits of relatives prohibition were introduced. However, the number of patients with depression returned to its previous level later in the pandemic.
This phenomenon may indicate psychological adaptation to the situation. The presented results of observation suggest that the introduction of limitations is less important than the particular perception of one’s situation and adaptation to that.
The Effect of Service Quality, Facilities and Location on Customer Satisfaction
Authors: Winata Edi 
Published: July 2023

This research was conducted to see the effect of waiters service quality, facilities and location on customer satisfaction at Mutia Garden Medan Restaurant. By using quantitative descriptive data analysis methods, and the analysis model is multiple linear regression, coefficient determination (R2), simultaneous test (F test), partial test (t test), while the application used to process data is spss 22 this study was conducted. The sampling technique used is simple random sampling, obtained a sample of 125 people as customers of this restaurant. By using questionnaires the authors did for data collection. From the results of data processing, it was found that the variables of service quality, facilities and location had a positive and significant effect on guest satisfaction both simultaneously and partially.
Pengembangan Buku Elektronik (E-Book) sebagai Media Pembelajaran Ekstrakurikuler Wajib Pramuka
Authors: Rahmadhani Sutrisza , Supriadi Supriadi , Okra Riri , Efriyanti Liza 
Published: July 2023

Penelitian ini dilatarbelakangi tentang persoalan peserta didik yang sering kehilangan buku dan materi pembelajaran pkstrakuerikuler pramuka sehingga kesulitan bagi peserta didik dalam memahami matei. Pengembangan E-book bertujuan memudahkan peserta didik dan pembimbing dalam proses pemahaman pramuka, baik itu pemahaman teori maupun praktek. Penelitian ini menggunakan metode Research and Development (RnD), dan pada tahapan pengembangannya memakai metode waterfall dengan model Pressman. Aplikasi dibangun dengan memakai software sublimetext, photoshop, coreldrar, filmora, dan memakai Bahasa pemrograman HTML dan CSS sebagai back end dan CSS bootsratp sebagai front end. Produk penelitian ini diuji dengan menggunakan formula rumus Aiken’s “V” untuk uji validitas, Formula Moment kappa untuk mendapatkan hasil uji praktikalitas dan formula Gain Score untuk mendapatkan nilai dari uji efektifitas. Berdasarkan ketiga pengujian yang telah didapatkatkan bahwa produk valid dengan hasil nilai 0.81 dengan kategori valid, hasil uji praktis dengan nilai 0.86 dengan kategeori kepraktisan tinggi, dan nilai efektifitas yaitu sebesar 0,88 dengan katergoi efetifitas sangat tinggi. Produk ini dapat mempermudah peserta didik dalam mengikuti kegiatan ekstrakurikuler pramuka dan dapat memprmudah pembimbing pramuka dalam menjelaskan materi pramuka.
Abstract
This research is motivated by the problem of students who often lose books and scout extracurricular learning materials so that it is difficult for students to understand the material. E-book development aims to facilitate students and supervisors in the process of understanding scouts, both theoretical and practical understanding. This study uses the Research and Development (RnD) method, and at the stage of development it uses the waterfall method with the Pressman model. The application is built using sublimetext, photoshop, coreldrar, filmora software, and uses HTML and CSS programming languages ​​as the back end and CSS bootsratp as the front end. The product of this research was tested using the Aiken's "V" formula to test the validity, the Moment kappa formula to get the results of the practicality test and the Gain Score formula to get the value of the effectiveness test. Based on the three tests that have been obtained, it is found that the product is valid with a value of 0.81 with a valid category, practical test results with a value of 0.86 with a high practicality category, and an effectiveness value of 0.88 with a very high effectiveness category. This product can make it easier for students to participate in scout extracurricular activities and can make it easier for scout supervisors to explain scout material