bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does adopting a healthy diet improve periodontal parameters in patients susceptible to periodontal disease? A systematic review
Authors: Glavin Charlotte , Gartshore James , Jackson Guy , Bonsor Steve 
Published: January 2025

Abstract
Objectives
The aim of this systematic review is to evaluate evidence relating to whether adopting a diet, associated with improved outcomes for chronic systemic diseases with an inflammatory component, can improve periodontal parameters in patients with periodontal diseases.

Data sources
Electronic databases and one platform were systematically searched; Medline, Embase, Web of Science and the Cochrane Library including references of relevant studies.

Data selection and extraction
1220 studies were identified of which 9 studies were eligible; 4 RCT’s, 1 controlled trial and 4 observational cohort studies

Data synthesis
8 out of 9 studies found improved periodontal parameters associated with a diet that was low in refined carbohydrates, low in saturated fats, high in fibre and high in nutrition but the studies were low to medium quality of evidence and the diets, method of recording the diets and periodontal parameters varied between the studies as did the study duration and age of participants.

Conclusion
Current evidence supports the hypothesis that adopting a healthy diet has the potential to positively impact periodontal parameters in patients with periodontal diseases, particularly in the older population but the effects may be negated by confounding factors such as smoking. 9 studies were included in the review which were rated moderate or low quality of evidence.
Heterochromatic gene silencing controls CD4+ T cell susceptibility to regulatory T cell-mediated suppression in a murine allograft model
Authors: Noguerol Julie , Laviolette Karl , Zahm Margot , Chaubet Adeline , Sahal Ambrine , Détraves Claire , Torres Romain , Demont Clothilde , Adoue Véronique , Joffre Carine , Cammas Florence , van Meerwijk Joost PM , Joffre Olivier P. 
Published: January 2025

AbstractProtective immune responses require close interactions between conventional (Tconv) and regulatory T cells (Treg). The extracellular mediators and signaling events that regulate the crosstalk between these CD4+ T cell subsets have been extensively characterized. However, how Tconv translate Treg-dependent suppressive signals at the chromatin level remains largely unknown. Here we show, using a murine bone marrow allograft model in which graft rejection is coordinated by CD4+ T cells and can be inhibited by Treg, that Treg-mediated T cell suppression involves Heterochromatin Protein 1 α (HP1α)-dependent gene silencing. Unexpectedly, our screen also reveals that T cells deficient for HP1γ or the methyltransferase SUV39H1 are better repressed by Treg than their wild-type counterparts. Mechanistically, our transcriptional and epigenetic profiling identifies HP1γ as a negative regulator of a gene network functionally associated with T-cell exhaustion, including those encoding the inhibitory receptors PD-1 and LAG-3. In conclusion, we identify HP1 variants as rheostats that finely tune the balance between tolerance and immunity. While HP1α converts immunosuppressive signals into heterochromatin-dependent gene silencing mechanisms, HP1γ adjusts Tconv sensitivity to inhibitory environmental signals.
Comparative measurement of short-term fluoride release and inhibition of caries around restoration by ion releasing restorative materials: an in vitro study
Authors: El-Adl Eman T. , Ebaya Maha M. , Habib El-Sayed E. , Zaghloul Nadia M. 
Published: January 2025

AbstractThe main objective of the current study is to compare short-term fluoride release of three ion releasing restorative materials and assess their inhibitory effect on secondary caries. Materials used in this study included, Self-adhesive hybrid composite (group A), Ion releasing flowable composite liner (group B), and alkasite restorative material (group C). Twenty-two discs were fabricated from each material for short-term fluoride release test, conducted on days 1, 7, and 14. For assessing secondary caries inhibition, sixty-six sound molar teeth were used and standardized class V cavities were prepared. Teeth were divided into three groups according to each material, followed by 800 cycles of thermocycling. Subsequently, teeth were immersed in a solution containing cariogenic bacteria for 30 days. After that, teeth were sectioned bucco-lingually and analyzed using a polarized light microscope to measure inhibition area, outer lesion depth, and extension. Data was statistically analyzed using different tests. The study results revealed a statistically significant differences in fluoride release existed among materials. Self-adhesive hybrid composite exhibited the highest fluoride release. Lesion extension and depth were statistically significantly greater next to Ion-releasing flowable composite liner. The inhibition areas next to the Self-adhesive hybrid composite were statistically significantly larger than the other two materials. In conclusion, all tested ion-releasing restorative materials displayed fluoride release and the potential to inhibit secondary caries formation. Self-adhesive hybrid composite demonstrated the highest fluoride-releasing potential and the greatest ability to inhibit secondary caries. Conversely, Ion-releasing flowable composite liner exhibited the least fluoride release with minimal secondary caries inhibition. Increasing fluoride release correlated with larger inhibition areas and reduced outer lesion depth and extension.
Emerging biofilm formation and disinfectant susceptibility of ESBL-producing Klebsiella pneumoniae
Authors: Khalefa Hanan S. , Arafa Amany A. , Hamza Dalia , El-Razik Khaled A. Abd , Ahmed Zeinab 
Published: January 2025

AbstractKlebsiella pneumoniae is an opportunistic pathogen responsible for various infections in humans and animals. It is known for its resistance to multiple antibiotics, particularly through the production of Extended-Spectrum Beta-Lactamases (ESBLs), and its ability to form biofilms that further complicate treatment. This study aimed to isolate and identify K. pneumoniae from animal and environmental samples and assess commercial disinfectants’ effectiveness against K. pneumoniae isolates exhibiting ESBL-mediated resistance and biofilm-forming ability in poultry and equine farms in Giza Governorate, Egypt. A total of 320 samples, including nasal swabs from equine (n = 60) and broiler chickens (n = 90), environmental samples (n = 140), and human hand swabs (n = 30), were collected. K. pneumoniae was isolated using lactose broth enrichment and MacConkey agar, with molecular confirmation via PCR targeting the gyrA and magA genes. PCR also identified ESBL genes (blaTEM, blaSHV, blaCTX-M, blaOXA-1) and biofilm genes (luxS, Uge, mrkD). Antimicrobial susceptibility was assessed, and the efficacy of five commercial disinfectants was evaluated by measuring inhibition zones. Klebsiella pneumoniae was isolated from poultry (13.3%), equine (8.3%), wild birds (15%), water (10%), feed (2%), and human hand swabs (6.6%). ESBL and biofilm genes were detected in the majority of the isolates, with significant phenotypic resistance to multiple antibiotics. The disinfectants containing peracetic acid and hydrogen peroxide were the most effective, producing the largest inhibition zones, while disinfectants based on sodium hypochlorite and isopropanol showed lower efficacy. Statistical analysis revealed significant differences in the effectiveness of disinfectants against K. pneumoniae isolates across various sample origins (P < 0.05). The presence of K. pneumoniae in animal and environmental sources, along with the high prevalence of ESBL-mediated resistance and biofilm-associated virulence genes, underscores the zoonotic potential of this pathogen. The study demonstrated that disinfectants containing peracetic acid and hydrogen peroxide are highly effective against ESBL-producing K. pneumoniae. Implementing appropriate biosecurity measures, including the use of effective disinfectants, is essential for controlling the spread of resistant pathogens in farm environments.
Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003–2016
Authors: Lan Youmian , Zheng Qiongbing , Li Meijing , Chen Jiexin , Huang Dongyang , Lin Ling 
Published: January 2025

AbstractInsulin resistance (IR) and abdominal obesity are key in osteoarthritis (OA) development. The triglyceride glucose (TyG) index, along with indicators such as the visceral adiposity index (VAI), and lipid accumulation product (LAP), are increasingly used to measure IR. This study aims to explore the associations between surrogate IR indexes and OA, assessing their diagnostic efficacy within American populations. This study included 14,715 adults from the National Health and Nutrition Examination Survey 2003–2016. Logistic regression models and restricted cubic spline were used to explore the relationship between surrogate IR indexes and OA. Receiver operating characteristic curves were constructed to assess the diagnostic efficacy of these indices, with the area under the curve (AUC) as the metric. TyG, glucose triglyceride-waist circumference (TyG-WC), glucose triglyceride-body mass index (TyG-BMI), glucose triglyceride-waist height ratio (TyG-WHtR), VAI and LAP were significantly and positively associated with the prevalence of OA (all p < 0.01). After adjusting for various potential confounders, TyG-WC, TyG-BMI, TyG-WHtR and LAP remained significantly correlated with the prevalence of OA. Furthermore, restricted cubic spline revealed a nonlinear association between TyG-BMI, TyG-WHtR and LAP (all P-non-linear < 0.05). Receiver operating characteristic curves indicated that TyG-WHtR (AUC 0.633) demonstrated more robust diagnostic efficacy. Additionally, the sensitivity analysis produced results consistent with the primary findings. TyG and its combination with obesity indicators and LAP, are positively associated with the prevalence of OA, with TyG-WHtR showing the highest diagnostic efficacy.
Electret integrated magnetic field sensor based on magnetostrictive polymer composite with nT resolution
Authors: Zimoch Lukas , Schröder Stefan , Elzenheimer Eric , Kaps Sören , Strunskus Thomas , Faupel Franz , Höft Michael , Adelung Rainer 
Published: January 2025

AbstractThe pursuit for advanced magnetoelectric field sensors has gained momentum, driven by applications in various fields, ranging from biomedical applications to soft robotics and the automotive sector. In this context, a capacitive read-out based magnetostrictive polymer composite (MPC) sensor element is introduced, offering a new perspective on magnetic field detection. The sensor element’s unique feature is the possibility to independently tailor its mechanical and magnetic properties. When compared to other composite-based magnetic field sensors, the limit of detection (LoD) is three orders of magnitude lower (95.6 nT/√Hz at a resonance frequency of 160.5 Hz). In contrast to other electret-based ME sensors, the LoD is reduced by a factor of 20. To the best of the authors’ knowledge, this work marks the first comprehensive attempt to characterize a sensor magnetically, aligning with the thorough assessment standards of ME sensors. This study aims to narrow the disparity between established magnetic field sensors, featuring consistent characterization protocols, and the novel MPC sensors, which often undergo limited magnetic characterization as part of their evaluation. The presented sensor, built from readily available materials, offers a versatile and tuneable platform for magnetic field detection, and ongoing research aims to unlock its full potential in diverse applications.
Translational and clinical comparison of whole genome and transcriptome to panel sequencing in precision oncology
Authors: Kerle Irina A. , Gross Thomas , Kögler Anja , Arnold Jonas S. , Werner Maximilian , Eckardt Jan-Niklas , Möhrmann Elena E. , Arlt Marie , Hutter Barbara , Hüllein Jennifer , Richter Daniela , Schneider Martin M. K. , Hlevnjak Mario , Möhrmann Lino , Hanf Dorothea , Heilig Christoph E. , Kreutzfeldt Simon , Teleanu Maria-Veronica , Schröck Evelin , Hübschmann Daniel , Horak Peter , Heining Christoph , Fröhling Stefan , Glimm Hanno 
Published: January 2025

AbstractPrecision oncology offers new cancer treatment options, yet sequencing methods vary in type and scope. In this study, we compared whole-exome/whole-genome (WES/WGS) and transcriptome sequencing (TS) with broad panel sequencing by resequencing the same tumor DNA and RNA as well as normal tissue DNA for germline assessment, from 20 patients with rare or advanced tumors, who were originally sequenced by WES/WGS ± TS within the DKFZ/NCT/DKTK MASTER program from 2015 to 2020. Molecular analyses resulted in a median number of 2.5 (gene panel) to 3.5 (WES/WGS ± TS) treatment recommendations per patient. Our results showed that approximately half of the therapy recommendations (TRs) of both sequencing programs were identical, while approximately one-third of the TRs in WES/WGS ± TS relied on biomarkers not covered by the panel. Eight of 10 molecularly informed therapy implementations were supported by the panel, the remaining two were based on biomarkers absent from the panel, highlighting the potential additional clinical benefit of WGS and TS.
Applying Normalisation Process Theory to a peer-delivered complex health intervention for people experiencing homelessness and problem substance use
Authors: Foster Rebecca , Carver Hannah , Matheson Catriona , Pauly Bernie , Wallace Jason , MacLennan Graeme , Budd John , Parkes Tessa 
Published: January 2025

Abstract
Background
The Supporting Harm Reduction through Peer Support (SHARPS) study involved designing and implementing a peer-delivered, harm reduction intervention for people experiencing homelessness and problem substance use. Normalisation Process Theory (NPT) provided a framework for the study.

Methods
Four Peer Navigators (individuals with personal experience of problem substance use and/or homelessness) were recruited and hosted in six third sector (not-for-profit) homelessness services in Scotland and England (United Kingdom). Each worked with participants to provide practical and emotional support, with the aim of reducing harms, and improving well-being, social functioning and quality of life. NPT guided the development of the intervention and, the process evaluation, which assessed the acceptability and feasibility of the intervention for this cohort who experience distinct, and often unmet, health challenges. While mixed-methods data collection was undertaken, this paper draws only on the qualitative data.

Results
The study found that, overall, the intervention is feasible, and acceptable to, the intervention participants, the Peer Navigators and staff in host settings. Some challenges were encountered but these were outweighed by benefits. NPT is particularly useful in encouraging our team to focus on the relationship between different aspects of the intervention and context(s) and identify ways of maximising ‘fit’.

Conclusions
To our knowledge, this is the first application of NPT to this cohort, and specifically by non-clinicians (peers) in non-healthcare settings (homelessness services). Our application of NPT helped us to identify ways in which the intervention could be enhanced, with the key aim of improving the health/well-being of this underserved group.
Neuro‐adaptive fractional order prescribed performance backstepping control for a class of strict‐feedback non‐linear systems
Authors: Zhao Le , Yang Guanci , Luo Kexin , He Ling 
Published: January 2025

AbstractTo suppress the non‐linear motion for a class of strict‐feedback fractional order non‐linear systems, and to improve their transient and steady‐state performance, a neuro‐adaptive prescribed performance backstepping control strategy suitable for a class of strict‐feedback non‐linear systems is proposed in this paper. Firstly, the interval Type‐2 fuzzy neural network is constructed to approximate the unknown non‐linear functions. Secondly, the tracking differentiator is introduced to address the problem of ‘explosion of complexity’ associated with the technique framework of backstepping. Then, a prescribed performance backstepping controller composed of predetermined performance functions and equivalent transformed errors, which can ensure that the tracking errors converge with the predetermined performance intervals for a class of strict‐feedback non‐linear systems, is designed within the technique framework of backstepping control. Finally, the stability analysis, two simulation experiments and comparative experiment results are presented to demonstrate the feasibility and effectiveness of the designed controller.
Evolution of the Sérsic index up to z = 2.5 from JWST and HST
Authors: Martorano M. , van der Wel A. , Baes M. , Bell E. F. , Brammer G. , Franx M. , Gebek A. , Meidt S. E. , Miller T. B. , Nelson E. , Nersesian A. , Price S. H. , van Dokkum P. , Whitaker K. E. , Wuyts S. 
Published: January 2025

Context. The Hubble Space Telescope (HST) has long been the only instrument able to allow us to investigate the structure of galaxies up to redshift z = 3, limited to the rest-frame UV and optical. The James Webb Space Telescope (JWST) is now unveiling the rest-frame near-IR structure of galaxies, less affected by dust attenuation and more representative of their underlying stellar mass profiles.
Aims. We measure the evolution with redshift of the rest-frame optical and near-IR Sérsic index (n), and examine the dependence on stellar mass and star-formation activity across the redshift range 0.5 ≤ z ≤ 2.5.
Methods. For an HST-selected parent sample in the CANDELS fields we infer rest-frame near-IR Sérsic profiles for ≈15 000 galaxies in publicly available NIRCam imaging mosaics from the COSMOS-Web and PRIMER surveys. We augment these with rest-frame optical Sérsic indices, previously measured from HST imaging mosaics.
Results. The median Sérsic index evolves slowly or not at all with redshift, except for very high-mass galaxies (M⋆ > 1011 M⊙), which show an increase from n ≈ 2.5 to n ≈ 4 at z < 1. High-mass galaxies have higher n than lower-mass galaxies (the sample reaches down to M⋆ = 109.5 M⊙) at all redshifts, with a stronger dependence in the rest-frame near-IR than in the rest-frame optical at z > 1. This wavelength dependence is caused by star-forming galaxies that have lower optical than near-IR n at z > 1 (but not at z < 1). Both at optical and near-IR wavelengths, star-forming galaxies have lower n than quiescent galaxies, confirming and fortifying the result that across cosmic time a connection exists between star-formation activity and the radial stellar mass distribution. Besides these general trends that confirm previous results, two new trends emerge: (1) at z > 1 the median near-IR n varies strongly with star formation activity, but not with stellar mass, and (2) the scatter in near-IR n is substantially higher in the green valley (0.25 dex) than on the star-forming sequence and among quiescent galaxies (0.18 dex) – this trend is not seen in the optical because dust and young stars contribute to the variety in optical light profiles. Our newly measured rest-frame near-IR radial light profiles motivate future comparisons with radial stellar mass profiles of simulated galaxies as a stringent constraint on processes that govern galaxy formation.
Étude qualitative descriptive, complémentaire à l’étude de 2021, sur l’utilisation de la simulation dans les enseignements des éducations en santé dans les instituts de formation en soins infirmiers d’Île-de-France
Authors: Pavageau Alice , Marchand Claire 
Published: January 2025

Introduction : Les professionnels de santé sont amenés à développer des compétences éducatives et préventives au service des prises en soins des patients. La formation infirmière prévoit une compétence spécifique que les étudiants abordent sur le plan théorique mais qu’ils ont peu l’occasion de mettre en pratique lors des stages. La simulation semble pouvoir pallier ce manque d’opportunités. Objectif : L’étude complémentaire à l’étude de 2021 vise à décrire plus précisément comment la simulation est utilisée dans les enseignements des éducations en santé en IFSI. Méthodes : Étude descriptive qualitative menée auprès de formateurs d’IFSI d’Île-de-France utilisant la simulation dans leurs enseignements des éducations en santé. Résultats : Dix entretiens semi-directifs ont été conduits dont neuf sont exploités. De façon générale, les formateurs utilisent le jeu de rôle particulièrement pour les enseignements de l’ETP. Les objectifs des séances visent l’application d’une étape de l’ETP et le développement d’une posture au service de l’éducation. Discussion : Les phases de la simulation respectent les recommandations de la HAS mais l’évaluation mériterait d’être davantage travaillée afin d’identifier les apprentissages réels par les séances de simulation. Les patients mériteraient d’être davantage impliqués dans ces projets au service de la professionnalisation des étudiants.
Association between Clot Waveform Analysis Parameters and the Severity of Liver Cirrhosis
Authors: Thanapirom Kessarin , Suksawatamnuay Sirinporn , Thaimai Panarat , Ananchuensook Prooksa , Kijrattanakul Pitiphong , Angchaisuksiri Pantep , Tangkijvanich Pisit , Treeprasertsuk Sombat , Komolmit Piyawat 
Published: January 2025

Background Clot waveform analysis (CWA) provides a global assessment of hemostasis and may be useful for patients with cirrhosis with complex hemostatic abnormalities. This study aimed to assess the association between prothrombin time (PT-) and activated partial thromboplastin time (aPTT-) based CWA parameters and cirrhosis severity and prospectively evaluate the role of CWA in predicting mortality and acute decompensation (AD) over 1 year.
Methods This prospective study included adult patients with cirrhosis between June 2021 and December 2023 at Chulalongkorn University Hospital. The PT- and aPTT-based CWA parameters were obtained using an automated coagulation analyzer.
Results A total of 560 patients with cirrhosis were included; 165 (29.5%) and 47 (11.5%) had Child–Turcotte–Pugh (CTP) B and C cirrhosis, respectively. The PT- and aPTT-based CWA parameters, including maximum velocity (min1), maximum acceleration (min2), and maximum deceleration (max2), were significantly lower (p ≤ 0.05) in patients with decompensated cirrhosis than in those with compensated cirrhosis. Additionally, CWA values were significantly higher in patients with higher CTP and Model for End-Stage Liver Disease (MELD) scores. Multivariable analysis revealed that liver stiffness (LS) and max2 of PT-based CWA assay were independently associated with CTP B/C. In addition, min2 and max2 of PT-based CWA assay were independently associated with 1-year mortality. No significant differences in CWA parameters were observed between patients with and without portal vein thrombosis. CWA parameters were not related to AD during the 1-year follow-up.
Conclusion A hypocoagulable profile based on CWA parameters is associated with advanced-stage cirrhosis. CWA may be a useful objective marker for assessing cirrhosis severity and predicting 1-year mortality.