bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain Oxygenation Response to Hypercapnia in Acute Brain Injured Patients
Authors: Anderloni Marco , Schuind Sophie , Salvagno Michele , Donadello Katia , Peluso Lorenzo , Annoni Filippo , Taccone Fabio Silvio , Bogossian Elisa Gouvea 
Published: May 2023

Abstract
Background
Cerebral hypoxia is a frequent cause of secondary brain damage in patients with acute brain injury. Although hypercapnia can increase intracranial pressure, it may have beneficial effects on tissue oxygenation. We aimed to assess the effects of hypercapnia on brain tissue oxygenation (PbtO2).
Methods
This single-center retrospective study (November 2014-June 2022) included all patients admitted to the Intensive Care Unit (ICU) after acute brain injury who required multimodal monitoring including PbtO2 and who underwent induced moderate hypoventilation and increased PaCO2, according to the decision of the treating physician. Patients with imminent brain death were excluded. “Responders” to hypercapnia were defined as those with an increase of at least 20% in PbtO2 values when compared to their baseline levels.
Results
On a total of 163 eligible patients, we identified 23 (14%) patients who underwent moderate hypoventilation (PaCO2 from 44 [42–45] to 50 [49–53] mmHg; p < 0.001) during the study period at a median of 6 (4–10) days following ICU admission; 6 patients had traumatic brain injury (TBI) and 17 had subarachnoid hemorrhage (SAH). A significant overall increase in median PbtO2 values from baseline [21 (19–26) to 24 (22–26) mmHg; p = 0.02] was observed. Eight (35%) patients were considered as “responders”, with a median increase of 7 (from 4 to 11) mmHg of PbtO2, while non-responders showed no changes (from − 1 to 2 mmHg of PbtO2). Due to the small sample size, no variable independently associated with PbtO2 response was identified. No correlation between the change in PaCO2 and in PbtO2 was observed.
Conclusions
In this study, a heterogeneous response of brain tissue oxygenation to induced hypercapnia was observed, but without any deleterious elevations of ICP.
Comparative Analysis of the Cutting Performances of SiAlON Ceramic, Cubic Boron Nitride and Carbide Cutting Tools for Titanium Machining
Authors: Phokobye Solomon Ntshiniki , Desai Dawood Ahmed , Tlhabadira Isaac , Sadiku Emmanuel Rotimi 
Published: May 2023

Abstract
The efficiency of machining operation is partly a function of the cutting parameters, such as the: cutting speed, depth of cut and cutting feed rate. With an effective cutting performance of any cutting tool, manufacturing industries will remain competitive and hence, strive to meet the dynamic service and functional requirements expected of the material. Hence, the purpose of this research is to experimentally perform a comparative analysis of the cutting performances of SiAlON, a ceramic alloy consisting of the elements: Silicon, Aluminium, Oxygen and Nitrogen, Cubic Boron Nitride (CBN) and Carbide cutting tools, during a titanium machining process. A face milling operation was performed on a computer numerical control (CNC) milling machine from these three different types of cutting tools, for the determination of the: cutting forces, cutting temperatures, cutting vibrations produced and the surface roughness, achieved during the machining of titanium (Ti-6Aℓ-4V) alloy. The Response Surface Methodology was adopted for the possible combination of the cutting parameters for the determination of the practical experimental results of the cutting responses.
Listeria Monocytogenes Meningoencephalitis in the Elderly Caused by Needle Injection: A Case Report
Authors: Du Yu , Xiang ShiZhao , Yang Ping 
Published: May 2023

Abstract
Background: Listeria is widely distributed in nature, and Listeria monocytogenes is the main strain that causes human infections. Listeriosis is usually a food-borne disease with low incidence and high mortality, and elderly individuals with low immunity are at a high risk of infection. However, we report a very rare case of injection-induced Listeria monocytogenesmeningoencephalitis in an elderly individual. The clinical characteristics of this case are different from those of healthy adults or food-borne infections with Listeria monocytogenes.
Case presentation: This case report describes an 80-year-old woman with diabetes who developed progressive coma, respiratory failure and shock due to repeated use of the same needle for injectinginsulin. Multiple examinations of cerebrospinal fluid pathogen culture werenegative, CT examination showed no specific changes, and the empirical use of antibiotics was ineffective. Listeria monocytogenes genes were found by next-generation sequencing of cerebrospinal fluid, and her infection was definitivelydiagnosed as Listeria monocytogenesmeningoencephalitis. After the appropriate antibiotic therapy, the patient's condition was well alleviated andreturned to normal life after six months of follow-up. Conclusions: We learned from the cases that Listeria monocytogenes meningoencephalitis in elderly individuals infected by nonfood-borne routes is characterized by occult onset, rapid progression, easily confused clinical manifestations and a low positive rate of cerebrospinal fluid culture. Due to easy misdiagnosis early on, a thorough examination should be started as soon as possible, and doctors should be aware of the symptoms of this disease. Early diagnosis and early treatment will helpreduce the mortality and debilitation caused by this disease.
The efficiency of Liposomal paclitaxel versus docetaxel in neoadjuvant chemotherapy on locally advanced nasopharyngeal carcinoma: a retrospective study
Authors: yang zhi , zuo quan , liu rong , wu hui , xiong li , jia Jieqi , xiang Zhibi 
Published: May 2023

Abstract
Purpose
This retrospective study aimed to explore the efficiency and untoward reaction of liposomal paclitaxel versus docetaxel for locally advanced nasopharyngeal carcinoma (NPC).
Methods
This study retrospectively enrolled 115 patients with NPC from our hospital from January 2018 to December 2021. Patients were divided into the liposomal paclitaxel (n = 71) and docetaxel groups (n = 44) following the neoadjuvant chemotherapy protocol. Objective response rate (ORR), progression-free survival (PFS), locoregional relapse-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were compared between the two groups.
Results
ORR was significantly improved in the liposomal paclitaxel group than in the docetaxel group (62.0% versus 40.9%, P = 0.028). The 3-year PFS (PFS: 84.4% versus 77.5%, P = 0.303), LRFS (95.8% versus 94.4%, P = 0.810), DMFS (87.2% versus 84.9%, P = 0.648), and OS (90.7% versus 88.8%, P = 0.306) revealed no significance. The neutrophil-to-lymphocyte ratio (hazard ratio [HR]: 3.510; P = 0.039) and distant metastasis (HR: 4.384; P = 0.035) were regarded as the risk factors using multivariate regression analysis. Moreover, the incidence of leukopenia at levels 1–2 in the liposomal paclitaxel group was significantly lower than in the docetaxel group (28.1% versus 79.5%, P < 0.05).
Conclusions
Liposomal paclitaxel had better efficacy in terms of short-term effects and lower incidence of leukopenia at levels 1–2 compared with the docetaxel group.
Reversed Phase Dispersive Liquid–Liquid Microextraction for Sensitive Ion Chromatographic Determination of Metal Cations in Sesame Oil
Authors: Jaberi Mohsen , Hashemi Payman , Rahimi Akram 
Published: May 2023

Abstract
Reversed-phase dispersive liquid-liquid microextraction (RP-DLLME) was proposed in the present work to separate and preconcentrate metal cations in sesame oil before their detection through ion chromatography-conductivity detection (IC-CDD). This method facilitates the direct extraction of cations like Na+, Pb2+, K+, Mg2+, and Ca2+ from oil specimens into an aqueous micro-drop to inject into the chromatography column. Four parameters were included in the process as the pH of water, volume of water and THF, and centrifugation time through a response surface technique. Five replicated analyses were performed under optimized circumstances (1.5 mL THF as a disperser and 60 µL water at pH 9 as an extraction solvent). Thus, recoveries of 110%, 108%, 107.2%, 104.2%, and 106.8% were displayed with respective standard deviations of 10.3, 9.8, 7.3, 9.7, and 6.7 for K+, Na+, Mg2+, Pb2+, and Ca2+. The detection limits (3σ) for the method were 0.007 µg mL− 1 for K+, 0.001 µg mL− 1 for Na+, 0.011 µg mL− 1 for Mg2+, 0.008 µg mL− 1 for Pb2+, and 0.009 µg mL− 1 for Ca2+. The method could successfully determine the existence of metal cations in four sesame oil specimens.
Understanding the interface between European wild boar (Sus scrofa) and domestic pigs (Sus scrofa domesticus) in Sweden through a questionnaire study
Authors: Ernholm Linda , Ståhl Karl , Neimanis Aleksija , Widgren Stefan , Sternberg-Lewerin Susanna 
Published: May 2023

Abstract
In recent years, the wildlife/livestock interface has attracted increased attention due to disease transmission between wild and domestic animal populations. The ongoing spread of African swine fever (ASF) in European wild boar (Sus scrofa) emphasize the need for further understanding of the wildlife/livestock interface to prevent disease spill-over between the wild and domestic populations. Wild boar may also act as a potential source for other infectious disease agents, although ASF may currently be considered the most severe threat from wild boar to domestic pigs. To gather information on the wild boar situation at commercial pig producing farms in Sweden, a digital questionnaire survey was distributed through the animal health services. Most pigs produced for commercial purposes in Sweden are raised without outdoor access. Around 80% of the responding pig producers saw wild boar or signs of wild boar activity in the vicinity of their farm at least once during the year. Observations were significantly correlated with geographical region, but there was no correlation between farm characteristics (farm size, main type of production, outdoor access) and observed wild boar presence or proximity. However, observations made in closer proximity to the farm were positively correlated with higher frequency of wild boar observations. Hunting and strategic baiting were the most common mitigation strategies used to keep wild boar at bay. At 12 out of 14 responding farms, pigs with outdoor access could be raised solely indoors, if needed. Pigs with outdoor access are required to be fenced in, but double fencing in these outdoor pig enclosures was not practiced by all. A perimeter fence surrounding any type of pig farm is very rare. More than half of the producers that grew crops with intended use for pigs reported crop damage by wild boar. This study shows that although pigs raised for commercial purposes in Sweden are, to a large extent, kept indoors the potential for indirect contact with wild boar exists and must be considered. Variable local situations may require an adaptive approach regarding biosecurity efforts.
An adaptive neural network sliding mode controller for nonlinear active suspension with uncertain parameters and non-ideal actuators
Authors: Shang Ting , Zhang Jianhong , Long Jiangqi 
Published: May 2023

Abstract
Active suspension systems (ASSs) are contributed to improving ride comfort and maneuverability. However, practical ASSs commonly suffer from nonlinear characteristics, uncertain parameters and non-ideal actuators, which always significantly deteriorate the control performance in practice. To overcome these issues, this paper proposes an adaptive neural network sliding mode control (ANNSMC) strategy for an ASS to achieve suspension performance improvements. Firstly, the skyhook system as a reference model which doesn’t require real-time measurement of road input is adopted to provide reference trajectories for the sprung mass displacement and velocity. In addition, an adaptive radial basis function neural network is designed and presented to deal with the effects of uncertain nonlinear functions in the dynamic system. Furthermore, the stability of the closed-loop system is proved by the Lyapunov stability theory. Finally, the effectiveness of the proposed controller is verified by numerical simulation and experimental platform, and the advantages of the proposed ANNSMC controller in suppressing suspension vibration are illustrated by comparing the performance of passive suspension (PS), sliding mode control (SMC) and linear quadratic regulator (LQR) controlled active suspension under different road excitations. The simulation and experimental results further demonstrate that the proposed controller can effectively suppress sprung mass vibrations and offers superior control performance despite the existence of nonlinear dynamics, uncertain parameters and non-ideal actuators.
Fabrication of Al/AlOx/Al junctions with high uniformity and stability on sapphire substrates
Authors: Zheng Yuzhen , Li Shuming , Ding Zengqian , Xiong Kanglin , Feng Jiagui , Yang Hui 
Published: May 2023

Abstract
Tantalum and aluminum on sapphire are widely used platforms for qubits of long coherent time. As quantum chips scale up, the number of Josephson junctions on Sapphire increases. Thus, both the uniformity and stability of the junctions are crucial to quantum devices, such as scalable superconducting quantum computer circuit, and quantum-limited amplifiers. By optimizing the fabrication process, especially, the conductive layer during the electron beam lithography process, Al/AlOx/Al junctions of sizes ranging from 0.0169 to 0.04 µm2 on sapphire substrates were prepared. The relative standard deviation of room temperature resistances (RN) of these junctions is better than 1.7% on 15 mm×15 mm chips, and better than 2.66% on 2 inch wafers, which is the highest uniformity on sapphire substrates has been reported. The junctions are robust and stable in resistances as temperature changes. The resistances increase by the ratio of 9.73% relative to RN as the temperature ramp down to 4K, and restore their initial values in the reverse process as the temperature ramps back to RT. After being stored in a nitrogen cabinet for 100 days, the resistance of the junctions changed by1.16% in average. The demonstration of uniform and stable Josephson junctions in large area paves the way for the fabrication of superconducting chip of hundreds of qubits on sapphire substrates.
Neurocomputational mechanisms of biased impression formation in lonely individuals
Authors: Park Soyoung , Bellucci Gabriele 
Published: May 2023

Abstract
Social impressions are fundamental in our daily interactions with other people but forming accurate impressions of our social partners can be biased to different extents. Loneliness has previously been suggested to induce biases that hinder the formation of accurate impressions of others for successful social bonding. Here, we demonstrated that despite counterfactual evidence, negative first impressions bias information weighting, leading to less favorable trustworthiness beliefs. Lonely individuals did not only have more negative expectations of others’ social behavior, but they also manifested a stronger weighting bias. Reduced orbitofrontal cortex (OFC) activity was associated with a stronger weighting bias in lonelier individuals and mediated the relationship between loneliness and this weighting bias. Importantly, stronger coupling between OFC and temporoparietal junction compensated for such effects, promoting more positive trustworthiness beliefs. These findings bear potential for future basic and clinical investigations on social cognition and the development of clinical symptoms linked to loneliness.
Inequities Among Hospital Donor Human Milk Access
Authors: Cohen Ronald , Joe Lenae , Kan Peiyi , Lee Henry , Toney-Noland Caroline 
Published: May 2023

Abstract
Objective
Donor human milk (DHM) can provide nutritional benefits to neonates. This study examines access to DHM and how structural barriers may exacerbate inequities.
Study Design
The median test and ANOVA test were used to compare the distribution maternal race/ethnicity and insurance status variables with DHM access for California NICUs in 2021.
Result
Across 124 NICUs, those serving a higher percentage of white families were more likely to have access to DHM (p = 0.04). NICUs with a higher percentage of Hispanic families were less likely to have access to DHM (p = 0.03). Hospitals that had higher proportions of uninsured patients were also less likely to have access to DHM (p = 0.015).
Conclusion
Inequities in DHM access and use among NICU infants begin at the structural level. Policies that reduce barriers to DHM access may reduce health inequities for Hispanic and uninsured families.
Oviposition preferences in temperate grasshoppers: Conserved temperature requirements but contrasting responses to humidity across species
Authors: Knapp Michal , Dvořák Tomáš 
Published: May 2023

Abstract
The right choice of an oviposition site is a crucial task for oviparous species without maternal care. In contrast to well investigated biotic factors, e.g., larval food preferences, parasitism, predation, and competition avoiding, abiotic factors affecting oviposition preferences in insects have been rarely investigated in comparative studies. To improve our current understanding of oviposition site selection in orthoptera, we investigated the influence of substrate temperature and moisture on oviposition behaviour for 14 temperate grasshopper species. Conspecific groups of adults were kept in arenas with simultaneous temperature and moisture gradients. For each ootheca produced during the experiment (1192 in total) we recorded its depth and local microclimatic conditions. Our results indicate that microclimatic oviposition preferences significantly differ among species, however, correlations between adult habitat preferences and microclimatic oviposition preferences were surprisingly weak. Even oligothermic species preferred substrate temperatures around 30°C and some xerothermic species preferred higher humidity. Hypothesized tendency to place oothecae closer to the ground within grass tussocks under hot and dry conditions was confirmed. It is possible that species evaluate microclimatic conditions for oviposition in the context of occupied habitat, i.e., in a relative rather than absolute manner.
Estimation of photosynthetic induction is significantly affected by inside and outside light intensity in Oryza genus
Authors: Xiong Zhuang , Xiao Jian , Zhao Jinfang , Liu Sicheng , Yang Desheng , Xiong Dongliang , Cui Kehui , Peng Shaobing , Huang Jianliang 
Published: May 2023

Abstract
Nowadays, an increasing number of scientists have realized the important role of photosynthetic induction and stomatal kinetics in regulating plant growth ang water use efficiency under fluctuating light environments. However, measurements of photosynthetic rate and stomatal conductance (gs) during light induction are differs among studies. On the other hands, it is still under debate whether steady- and non-steady state gs are related to stomatal morphology. Here, we observed a strong effect of inside and outside light intensity of leaf chamber on photosynthetic induction. Lower light significantly decreased photosynthetic induction by altering stomatal and biochemical processes. It is meaningful to measuring photosynthetic induction on a whole plants irradiated environment in the future. Moreover, higher density of smaller stomata contributed to the response of stomatal opening and photosynthetic rate to fluctuating light, but had little effect on gs,steady under a constant light condition. Our findings may be beneficial to estimate rice photosynthetic efficiency under fluctuating light environments in the future.
Identification of Mine Water Sources using a Multi-Dimensional Ion-Causative Nonlinear Algorithmic Model
Authors: Zheng Qiushuang , Liu Weitao , Yang Yang , Zhu Ye 
Published: May 2023

Abstract
This paper investigates the water quality system using the Piper diagram method to qualitatively analyze the distribution, characteristics, and laws of typical ion content. It also compares the differences between ion components of each aquifer with the closeness of the water body to be discriminated by combining statistical characteristic values. The R factor is utilized to simplify the index attributes, reduce input information dimension, and construct the coupled R-SVM discriminative model of Zhaogezhuang Mine. The input index is established as typical ion content, and the output is water source type. The discriminative model automatically establishes the mapping relationship between water quality indexes and discriminative criteria by learning the inherent property law between water quality samples. The independence components after dimensionality reduction are used as new discriminative indexes. The accuracy of the coupled model classification was 90.90% in the verification of the water source discrimination example of Zhaogezhuang mine. The coupled quantitative discriminant model based on R-factor and support vector machine provides an auxiliary verification and scientific decision for qualitative water chemistry analysis and provides a new idea for water source identification. Compared with the traditional qualitative way of water chemistry characteristics, Fisher function discrimination method, and single support vector machine model, this method improved the accuracy by more fully exploiting the internal laws of the data.
Perspectives on Acute Myeloid Leukemia Diagnosis: A Comparative Analysis of the Latest World Health Organization and the International Consensus Classifications
Authors: Jung Jin , Kwag Daehun , Kim Yonggoo , Lee Jong-Mi , Ahn Ari , Kim Hoon Seok , Bae Byunggyu , Park Silvia , Kim Hee-Je , Cho Byung-Sik , Kim Myungshin 
Published: May 2023

Abstract
This study compares and analyzes the 5th edition of the WHO classification (WHO 2022) and the International Consensus Classification (ICC) in the context of 861 acute myeloid leukemia (AML) patients from Seoul St. Mary's Hospital. Using WHO 2022, 154 patients were reclassified from WHO 2016, including 23 with KMT2A rearrangement and additional 23 with other genetic abnormalities. AML myelodysplasia-related (AML-MR) category was significantly affected by the WHO 2022, with 8.2% reclassified from AML with RUNX1 mutation and 15.2% from AML-not otherwise specified when the majority of them were from AML-myelodysplasia related changes (AML-MRC) according to WHO 2016. AML-MR showed significantly worse survival outcomes than AML defined by differentiation. Among the AML-MR subgroup, patients with a history of myelodysplastic syndrome or myelodysplastic syndrome/myeloproliferative disorder had a poorer prognosis compared to AML-MR defined by mutation and/or cytogenetics. ICC adopted three categories associated with AML-MRC: 34 patients with AML with mutated TP53, 169 with AML-MR-gene mutations, and 67 with AML-MR-cytogenetic abnormalities among included patients. AML with mutated TP53, mostly from AML-MRC, was an unfavorable subtype with poor prognostic outcomes. Our evaluation supports the refinements made in WHO 2022 and ICC of AML and proposes additional refinements to provide more accurate prognostic information.