bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mediation model of learning organization, technology acceptance, and service innovation: accommodation purchase managers’ perceptions in Antalya, Turkey: Part II
Authors: Kalıpçı Mehmet Bahadır 
Published: January 2023

Purpose
This study aims to analyze the theoretical complexity that underlies purchase managers’ perceptions of their ability to take part in the implementation of a new back-office service strategy.

Design/methodology/approach
A survey of purchasing department managers in the Antalya (Turkey) region was conducted. The purchasing managers of Antalya’s five-star accommodation businesses comprise the research sample.

Findings
Within the scope of the study, 205 questionnaires were gathered. Factor analysis, correlation and regression analysis were applied to the obtained data. The learning organization (LO) consists of three factors (organization, group/team and individual), service innovation (SI) consists of two factors (employee innovation behavior and new service development) and technology acceptance (TA) consists of four factors (perceived usefulness, perceived ease of use, facilitating situations and social factors), according to the findings of the factor analysis. According to correlation analysis, LO, SI and TA all have positive and significant relationships. The LO has been observed to play an intermediary function in the relationship between TA and SI as a consequence of the analysis that determines the mediation effect.

Originality/value
This study which dealt with the dimensions of SI, TA and LO showed a proposed model which gives a better understanding of how the development of back-office system strategies is affected by LOs.
Decent work in traditional tourism destinations: Tourism Agenda 2030 perspective article
Authors: Maggi Rico , Vroegop Eva 
Published: January 2023

Purpose
Discussing tendencies and shortcomings in the current debate on promoting decent work in hospitality and tourism, this study aims to respond to recent calls for progress on improving employee well-being. It proposes elements of a productivity-based strategy embedded in a circular dynamic linking productivity, service quality, profitability and job quality to enhance tourism employees’ well-being in view of achieving Sustainable Development Goal 8 on decent work.

Design/methodology/approach
Drawing on recent empirical work on gift exchange theory, this viewpoint article presents a possible scenario that should stimulate debate among scholars and local policymakers of how decent work and quality of life can be achieved in traditional tourism destinations. This would fill a gap in the current debate, which focuses on quantitatively marginal alternative forms of tourism, to overcome problems inherent to growth-based tourism.

Findings
This contribution proposes a productivity-based development strategy supported by an incentive regulation policy targeting employers who provide tourist services in mass tourism destinations, promoting job quality to raise productivity and enhance service quality and in the end profitability.

Originality/value
This short article proposes a new perspective on promoting decent work in traditional tourism destinations based on gift exchange theory and discusses the scope for research essential to support a development based on the scenario described by a circular model.
Modelling harvest of Greenland barnacle geese and its implications in mitigating human–wildlife conflict
Authors: McIntosh Aimée L. S. , Bearhop Stuart , Hilton Geoff M. , Shaw Jessica M. , Johnson Fred A. 
Published: January 2023

Abstract

Arctic‐breeding goose populations have increased in recent decades and their expansion into agricultural areas has caused increasing conflict with farmers due to the damage they cause. Lethal control and scaring are common management strategies of conflict mitigation. Management typically focuses on local/national scales, making addressing the impact of localised control on the wider population challenging, particularly when populations move over large areas and cross international borders.

We construct an integrated population model (IPM) to assess the cumulative impact of all shooting harvest (hunting and derogation shooting) on the Greenland barnacle goose, Branta leucopsis. We use data from monitoring schemes throughout the migratory flyway and use population projections to evaluate the impact of potential future shooting strategies on abundance.

Our model suggests flyway abundance has declined since its 2012 peak, consistent with an increase in harvest rate and low productivity. Harvest rate increase was most pronounced on Islay (rising from 2% to 7% from 2011 to 2017), suggesting this was a probable cause of flyway abundance decline.

Islay abundance has declined since derogation shooting began in 2000, while abundance at other wintering sites has increased. This may indicate that declines in Islay abundance may be due to both shooting mortality and emigration from Islay.

Should future flyway‐level harvest rates increase, further declines in abundance could be expected, and are likely to be more pronounced if harvests are extended to the entire winter range. Conversely, should harvest rates decline, an increase in abundance is predicted. Projections can therefore be used to allocate flyway‐level harvest rates to alleviate local pressure without hindering flyway‐level management objectives.

Synthesis and applications. Our findings demonstrate the impact of local harvests on global abundance, emphasising the importance of internationally coordinated monitoring and management strategies of migratory species. IPMs provide a framework for adaptation to incorporate additional data when they become available and enable comparisons of future harvest scenarios to inform management strategies throughout the flyway.
Sociology after the postcolonial: Response to Julian Go's ‘thinking against empire’
Authors: Valluvan Sivamohan , Kapoor Nisha 
Published: January 2023

AbstractJulian Go's ‘Thinking Against Empire’ identifies the corpus of ‘anticolonial thought’ as being instructive for a wider rethinking of how sociology might rally its key conceptualisations of social relations. He insightfully identifies the marginalisation of such thinking from Sociology as an institutionalised discipline. In our response we take up some of the warnings Go provides in the closing sections of his essay—which concern the expanse of intellectual engagement being currently bracketed under or connected to the ‘anti‐colonial’, not least vis‐à‐vis the ‘decolonising/decolonial’ turn—to further unpack how the ‘anti‐colonial’ might be adapted for thinking through contemporary socio‐political dynamics. Offering, first, a precis of some particularities of British Sociology vis‐a‐vis the contributions of anticolonial social theory, this article then expands upon the dilemmas arising when anticolonial theory contemporaneous to the pre‐decolonisation era is transposed to contingencies of the present 21st century. Namely, whilst the anticolonial archive has proved invaluable to upending the omissions but also complicities of European social theory canons, allowing for a much more expansive sense of how the modern world and its violences were conjured and how we might accordingly escape its miseries, it is also clear that much of the postcolonial world has undergone sufficient shifts to warrant an adapted sense of how we consider the anti‐colonial for our current politics. We suggest that the important deviations which anti‐colonial theorisations might heed include the dangers of conflating the anticolonial with an affirmation of Global South, non‐white nativist identity; the need to recognise some key conjunctural premises by which the anticolonial is no longer geographically indexed to a straightforward Global North‐Global South distinction; and the need to acknowledge that, at its most radical, anticolonial thought is itself still invested in traversing both the dreams but also corruptions of those dreams as intrinsic to modernity.
RNA‐Seq‐Pop: Exploiting the sequence in RNA sequencing—A Snakemake workflow reveals patterns of insecticide resistance in the malaria vector Anopheles gambiae
Authors: Nagi Sanjay C. , Oruni Ambrose , Weetman David , Donnelly Martin J. 
Published: January 2023

AbstractWe provide a reproducible and scalable Snakemake workflow, called RNA‐Seq‐Pop, which provides end‐to‐end analysis of RNA sequencing data sets. The workflow allows the user to perform quality control, perform differential expression analyses and call genomic variants. Additional options include the calculation of allele frequencies of variants of interest, summaries of genetic variation and population structure, and genome‐wide selection scans, together with clear visualizations. RNA‐Seq‐Pop is applicable to any organism, and we demonstrate the utility of the workflow by investigating pyrethroid resistance in selected strains of the major malaria mosquito, Anopheles gambiae. The workflow provides additional modules specifically for An. gambiae, including estimating recent ancestry and determining the karyotype of common chromosomal inversions. The Busia laboratory colony used for selections was collected in Busia, Uganda, in November 2018. We performed a comparative analysis of three groups: a parental G24 Busia strain; its deltamethrin‐selected G28 offspring; and the susceptible reference strain Kisumu. Measures of genetic diversity reveal patterns consistent with that of laboratory colonization and selection, with the parental Busia strain exhibiting the highest nucleotide diversity, followed by the selected Busia offspring, and finally, Kisumu. Differential expression and variant analyses reveal that the selected Busia colony exhibits a number of distinct mechanisms of pyrethroid resistance, including the Vgsc‐995S target‐site mutation, upregulation of SAP genes, P450s and a cluster of carboxylesterases. During deltamethrin selections, the 2La chromosomal inversion rose in frequency (from 33% to 86%), supporting a previous link with pyrethroid resistance. RNA‐Seq‐Pop is hosted at: github.com/sanjaynagi/rna‐seq‐pop. We anticipate that the workflow will provide a useful tool to facilitate reproducible, transcriptomic studies in An. gambiae and other taxa.
Repeat dose steroid in high pain responders after total knee arthroplasty: A study protocol
Authors: Springborg Anders H. , Varnum Claus , Nielsen Niklas I. , Rasmussen Lasse E. , Kjærsgaard‐Andersen Per , Pleckaitiene Lina , Gromov Kirill , Troelsen Anders , Kehlet Henrik , Foss Nicolai B. 
Published: January 2023

AbstractPain after total knee arthroplasty (TKA) is a well‐known clinical problem potentially delaying ambulation and recovery. Perioperative glucocorticoids reduce pain and facilitate early recovery, but the optimal timing and dose are still unknown. High pain catastrophizers have an increased risk of poorly controlled postoperative pain, and moderate to severe pain at 24 h is associated with a risk of pain relapse at 48 h. To evaluate the effect of a repeat moderate dose of glucocorticoids after TKA in high pain catastrophizers presenting with moderate to severe pain 24 h postoperatively, having received preoperative high‐dose glucocorticoids. High pain catastrophizers (Pain Catastrophizing Scale > 20) undergoing TKA are screened 24 h postoperatively and are included if they experience moderate to severe pain (VAS > 30) during a 5 m walk test. The included patients will receive either oral 24 mg dexamethasone (n = 55) or placebo (n = 55) on the evening of Day 1 (~30–37 h) after surgery. In addition, patients receive a standard multimodal analgesic regimen, including paracetamol, celecoxib, local infiltration analgesia, and preoperative dexamethasone (1 mg/kg). Patients will fill out a pain diary for 7 days after surgery. The primary outcome is moderate to severe pain (VAS > 30) during a 5 m walk test on the morning of Day 2 after surgery. The secondary outcomes include cumulated pain at rest and during ambulation, cumulated use of rescue analgesics, quality of sleep, lethargy, dizziness, nausea, satisfaction with the analgesic regimen, length of stay, morbidity, mortality, and reasons for readmissions. Follow‐up is at 8 and 30 days. The data from this study will provide evidence for the effect of a repeated dose of dexamethasone as an analgesic adjuvant in patients undergoing TKA with a high risk of postoperative pain.
Staged treatment of placenta accreta spectrum: A combined surgical and radiological approach
Authors: West Simon , Martin Amy , Copping Ross , Gard Greg , Maher Richard , Seeho Sean 
Published: January 2023

BackgroundPlacenta accreta spectrum (PAS) is a rare but serious complication of pregnancy.AimsThe aim of this study was to determine maternal and neonatal outcomes following a combined surgical and interventional radiology (IR) approach to managing PAS, and the risks associated with this technique.Methods and MaterialsRetrospective cohort study of all cases of PAS in a tertiary maternity centre between January 2001 and July 2020. Women who underwent caesarean hysterectomy for histologically confirmed PAS with a staged surgical and IR approach were compared with those who underwent caesarean hysterectomy without IR. Maternal, neonatal outcomes, surgical and radiological complications were assessed.ResultsForty‐six women were included in the study, and 30/46 (65.2%) underwent the staged surgical and IR approach. Women in the staged group had less overall blood loss (1794 mL vs 3713 mL; P < 0.001), less requirement for blood transfusion (40% vs 75%; P < 0.001), and a lower mean volume of packed red cells transfused (2.5 vs 6.1 units). Anaesthetic and operative times were longer for the staged group (468 vs 189 min: 272 vs 141 min P < 0.001), respectively. There were no differences in rates of neonatal or maternal complications between the two groups.ConclusionThis study demonstrates that a staged procedure combining surgery and IR for PAS results in a considerable reduction in blood loss, need for transfusion, and units of packed red cells transfused compared with surgery alone. The staged procedure required significantly longer anaesthetic and operative times; however, there were no differences in maternal and neonatal morbidity.
Environmental risk assessment of propofol in wastewater: a narrative review of regulatory guidelines
Authors: Waspe J. , Orr T. 
Published: January 2023

SummaryConcerns relating to the negative environmental impacts of anaesthesia are increasing, and in recent years, there has been an environmentally motivated trend towards greater use of propofol‐based total intravenous anaesthesia. Consequently, the environmental burden of propofol waste and disposal, particularly into wastewater, has gained attention. Current literature reporting levels of propofol in wastewater are scarce and the threat this presents to the environment is unclear. We review the regulatory requirements for conducting an environmental risk assessment, with a focus on the process for analysing whether drugs or drug metabolites cause harm to aquatic species. Furthermore, we present a profile for the aquatic toxicity of propofol based on available data and discuss the implications of this for future practice.
Time trends, projections, and spatial distribution of low birthweight in Australia, 2009–2030: Evidence from the National Perinatal Data Collection
Authors: Huda M. Mamun , Callaway Leonie K. , Jackson Greg , Fatima Yaqoot , Cumming Janet , Biswas Tuhin , Paz Gonzalo R. , Boyle Fran , Sly Peter D. , Mamun Abdullah Al 
Published: January 2023

AbstractIntroductionInfants with low birthweight (LBW, birthweight <2500 g) have increased in many high‐resource countries over the past two decades. This study aimed to investigate the time trends, projections, and spatial distribution of LBW in Australia, 2009–2030.MethodsWe used standard aggregate data on 3 346 808 births from 2009 to 2019 from Australia's National Perinatal Data Collection. Bayesian linear regression model was used to estimate the trends in the prevalence of LBW in Australia.ResultsWefound that the prevalence of LBW was 6.18% in 2009, which has increased to 6.64% in 2019 (average annual rate of change, AARC = +0.76%). If the national trend remains the same, the projected prevalence of LBW in Australia will increase to 7.34% (95% uncertainty interval, UI = 6.99, 7.68) in 2030. Observing AARC across different subpopulations, the trend of LBW was stable among Indigenous mothers, whereas it increased among non‐Indigenous mothers (AARC = +0.81%). There is also an increase among the most disadvantaged mothers (AARC = +1.08%), birthing people in either of two extreme age groups (AARC = +1.99% and +1.53% for <20 years and ≥40 years, respectively), and mothers who smoked during pregnancy (AARC = +1.52%). Spatiotemporal maps showed that some of the Statistical Area level 3 (SA3) in Northern Territory and Queensland had consistently higher prevalence for LBW than the national average from 2014 to 2019.ConclusionOverall, the prevalence of LBW has increased in Australia during 2009–2019; however, the trends vary across different subpopulations. If trends persist, Australia will not achieve the Sustainable Development Goals (SDGs) target of a 30% reduction in LBW by 2030. Centering and supporting the most vulnerable subpopulations is vital to progress the SDGs and improves perinatal and infant health in Australia.
Australian women's views concerning non‐medical egg freezing and factors motivating freezing decisions
Authors: Arendt Molly , Oxlad Melissa 
Published: January 2023

AbstractObjectiveWe aimed to determine women's views about egg freezing for non‐medical reasons and the factors motivating freezing decisions.DesignIn this study, 514 women aged 18–44 years completed an online cross‐sectional survey exploring fertility knowledge, reproductive intentions and views concerning non‐medical egg freezing.MethodsData were analysed descriptively. Additionally, 14 variables noted as potential motivators in prior literature were entered into a multinomial regression to explore factors that would motivate women to consider freezing their eggs for non‐medical reasons.ResultsViews concerning non‐medical egg freezing were generally positive, with 61.3% of participants reporting that they would consider egg freezing (‘Yes’ or ‘Maybe’). Factors motivating decisions to freeze varied among women who responded ‘Yes’, ‘Maybe’ and ‘I don't know’ to whether they would consider freezing. The availability of Medicare subsidization and the procedure not affecting future fertility were significant predictors for all three groups of women.ConclusionsAcceptability of egg freezing for non‐medical reasons was moderate to high. However, there is a need for targeted fertility information to educate women about fertility and optimal times to conceive and freeze their eggs. Future research about views concerning non‐medical egg freezing among diverse populations and examining the health economics of this procedure would be beneficial.
Protocol for the TRANSLATE prospective, multicentre, randomised clinical trial of prostate biopsy technique
Authors: Bryant Richard J. , Yamamoto Hide , Eddy Ben , Kommu Sashi , Narahari Krishna , Omer Altan , Leslie Tom , Catto James W. F. , Rosario Derek J. , Good Daniel W. , Gray Rob , Liew Matthew P. C. , Lopez J. Francisco , Campbell Teresa , Reynard John M. , Tuck Steve , Barber Vicki S. , Medeghri Nadjat , Davies Lucy , Parkes Matthew , Hewitt Aimi , Landeiro Filipa , Wolstenholme Jane , Macpherson Ruth , Verrill Clare , Marian Ioana R. , Williams Roxanne , Hamdy Freddie C. , Lamb Alastair D. 
Published: January 2023

ObjectivesPrimary objectives: to determine whether local anaesthetic transperineal prostate (LATP) biopsy improves the detection of clinically significant prostate cancer (csPCa), defined as International Society of Urological Pathology (ISUP) Grade Group ≥2 disease (i.e., any Gleason pattern 4 disease), compared to transrectal ultrasound‐guided (TRUS) prostate biopsy, in biopsy‐naïve men undergoing biopsy based on suspicion of csPCa. Secondary objectives: to compare (i) infection rates, (ii) health‐related quality of life, (iii) patient‐reported procedure tolerability, (iv) patient‐reported biopsy‐related complications (including bleeding, bruising, pain, loss of erectile function), (v) number of subsequent prostate biopsy procedures required, (vi) cost‐effectiveness, (vii) other histological parameters, and (viii) burden and rate of detection of clinically insignificant PCa (ISUP Grade Group 1 disease) in men undergoing these two types of prostate biopsy.Patients and MethodsThe TRANSLATE trial is a UK‐wide, multicentre, randomised clinical trial that meets the criteria for level‐one evidence in diagnostic test evaluation. TRANSLATE is investigating whether LATP biopsy leads to a higher rate of detection of csPCa compared to TRUS prostate biopsy. Both biopsies are being performed with an average of 12 systematic cores in six sectors (depending on prostate size), plus three to five target cores per multiparametric/bi‐parametric magnetic resonance imaging lesion. LATP biopsy is performed using an ultrasound probe‐mounted needle‐guidance device (either the ‘Precision‐Point’ or BK UA1232 system). TRUS biopsy is performed according to each hospital's standard practice. The study is 90% powered to detect a 10% difference (LATP biopsy hypothesised at 55% detection rate for csPCa vs 45% for TRUS biopsy). A total of 1042 biopsy‐naïve men referred with suspected PCa need to be recruited.ConclusionsThis trial will provide robust prospective data to determine the diagnostic ability of LATP biopsy vs TRUS biopsy in the primary diagnostic setting.
Stimulation of platelet P2Y1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling
Authors: Arkless Kate L. , Pan Dingxin , Shankar‐Hari Manu , Amison Richard T. , Page Clive P. , Rahman Khondaker Miraz , Pitchford Simon C. 
Published: January 2023

Background and PurposePlatelet function during inflammation is dependent on activation by endogenous nucleotides. Non‐canonical signalling via the P2Y1 receptor is important for these non‐thrombotic functions of platelets. However, apart from ADP, the role of other endogenous nucleotides acting as agonists at P2Y1 receptors is unknown. This study compared the effects of ADP, Ap3A, NAD+, ADP‐ribose, and Up4A on platelet functions contributing to inflammation or haemostasis.Experimental ApproachPlatelets obtained from healthy human volunteers were incubated with ADP, Ap3A, NAD+, ADP‐ribose, or Up4A, with aggregation and fibrinogen binding measured (examples of function during haemostasis) or before exposure to fMLP to measure platelet chemotaxis (an inflammatory function). In silico molecular docking of these nucleotides to the binding pocket of P2Y1 receptors was then assessed.Key ResultsPlatelet aggregation and binding to fibrinogen induced by ADP was not mimicked by NAD+, ADP‐ribose, and Up4A. However, these endogenous nucleotides induced P2Y1‐dependent platelet chemotaxis, an effect that required RhoA and Rac‐1 activity, but not canonical PLC activity. Analysis of molecular docking of the P2Y1 receptor revealed distinct differences of amino acid interactions and depth of fit within the binding pocket for Ap3A, NAD+, ADP‐ribose, or Up4A compared with ADP.Conclusion and ImplicationsPlatelet function (aggregation vs motility) can be differentially modulated by biased‐agonist activation of P2Y1 receptors. This may be due to the character of the ligand‐binding pocket interaction. This has implications for future therapeutic strategies aimed to suppress platelet activation during inflammation without affecting haemostasis as is the requirement of current ant‐platelet drugs.LINKED ARTICLESThis article is part of a themed issue on Platelet purinergic receptor and non‐thrombotic disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.4/issuetoc