bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smoking and secondary ACL rupture are detrimental to knee health post ACL injury—a Bayesian analysis
Authors: Nicholls Micah , Ingvarsson Thorvaldur , Filbay Stephanie , Lohmander Stefan , Briem Kristin 
Published: August 2023

AbstractPurposeTo identify potential prognostic factors for patient‐reported outcomes in an Icelandic cohort of ACL injured subjects.MethodsAll knee MRI reports written in Iceland between the years 2001 to 2011 were read to identify individuals with a possible ACL injury. These individuals were contacted and asked to complete an online questionnaire regarding their injury and current knee related health. The questionnaire collected information on years since surgery, injury circumstance, brace use, physiotherapy, ACL surgery, second ACL injury and current smoking status. In addition, the baseline status of their meniscii were assessed from the original MRI report and medical records were used to identify any subsequent, non‐ACL surgery. The patient‐reported Knee Osteoarthritis and Injury Outcome Score (KOOS) was used assess current knee related health. A Bayesian proportional odds model was used to assess the effect of all potential prognostic factors above as well as age and sex on KOOS outcomes.ResultsA total of 408 subjects completed the questionnaire indicating that they did rupture their ACL. The following variables were associated with worse outcomes across all KOOS subscales: having a subsequent arthroscopy, reinjury to your ACL, and smoking. Having physiotherapy for 9 months was associated with worse KOOS pain scores than having 6 months of physiotherapy. Conversely KOOS pain score tended to be higher if you injured your knee during sports.ConclusionReinjuring your ACL, smoking and having subsequent (non‐ACLR) surgery predict your knee related health following an ACL injury. Strategies should be implemented to reduce the risk of secondary ACL injury, and patients should be strongly advised not to smoke.
Perioperative lung function following flow controlled ventilation for robot-assisted prostatectomies in steep trendelenburg position: an observational study
Authors: Syrafe Mustafa , Köhne Wiebke , Börgers Andre , Löwen Heinrich , Krege Susanne , Groeben Harald 
Published: August 2023

AbstractBackgroundSteep Trendelenburg position combined with capnoperitoneum can lead to pulmonary complications and prolonged affection of postoperative lung function. Changes in pulmonary function occur independent of different modes of ventilation and levels of positive end-expiratory pressure (PEEP). The effect of flow-controlled ventilation (FCV) has not been evaluated yet. We perioperatively measured spirometric lung function parameters in patients undergoing robot-assisted prostatectomy under FCV. Our primary hypothesis was that there is no significant difference in the ratio of the maximal mid expiratory and inspiratory flow (MEF50/MIF50) after surgery.MethodsIn 20 patients, spirometric measurements were obtained preoperatively, 40, 120, and 240 min and 1 and 5 days postoperatively. We measured MEF50/MIF50, vital capacity (VC), forced expiratory volume in 1 s (FEV1), and intraoperative ventilation parameters.ResultsMEF50/MIF50 ratio increased from 0.92 (CI 0.73–1.11) to 1.38 (CI 1.01–1.75,p < 0.0001) and returned to baseline within 24 h, while VC and FEV1 decreased postoperatively with a second nadir at 24 h and only normalized by the fifth day (p < 0.0001). Compared to patients with PCV, postoperative lung function changes similarly.ConclusionFlow-controlled ventilation led to changes in lung function similar to those observed with pressure-controlled ventilation. While the ratio of MEF50/MIF50 normalized within 24 h, VC and FEV1 recovered within 5 days after surgery.
Successful endovascular embolization of the common hepatic artery for pseudoaneurysm associated with pancreatic fistula after liver transplantation: a case report
Authors: Sasaki Kazuki , Asaoka Tadafumi , Kobayashi Shogo , Iwagami Yoshifumi , Yamada Daisaku , Tomimaru Yoshito , Noda Takehiro , Wada Hiroshi , Gotoh Kunihito , Takahashi Hidenori , Maeda Noboru , Kimura Yasushi , Ono Yusuke , Doki Yuichiro , Eguchi Hidetoshi 
Published: August 2023

Abstract
Background
After orthotopic liver transplantation (OLT), complications such as hepatic artery stenosis, thrombosis, and bleeding are possible. Hepatic artery pseudoaneurysms (HAP) are prone to rupture, rupture hemorrhage, and increased mortality risk. Endovascular treatment of HAP may result in recurrence, even after successful embolization with thrombin. Formation of a HAP in the common hepatic artery (CHA) is challenging because the CHA is the only artery in the liver graft after OLT. Therefore, CHA embolization in HAP is not an initial option. We report a case of HAP at the CHA after OLT that was treated with endovascular therapy, resulting in the occlusion of the CHA with coil embolization, achieving a radical cure.

Case presentation
A 59-year-old man with decompensated hepatitis C virus cirrhosis underwent deceased donor whole-liver transplantation after graft failure of a living donor liver transplantation. After the second transplantation, the patient developed infectious narrow-necked HAP at the CHA associated with postoperative pancreatic fistula. Repeated transcatheter arterial embolization with thrombin and n-butyl-2-cyanoacrylate was unsuccessful, as confirmed by postprocedure angiography, which revealed recanalization and regrowth of the HAP. Eight months after the first transcatheter arterial embolization, the patient presented with a chief complaint of abdominal pain due to an enlarged HAP. Angiography of the superior mesenteric artery (SMA) revealed a collateral bypass around the bile duct from the SMA to the liver graft. Coil embolization of the HAP in the CHA completely occluded the HAP without complications. More than 2 years after coil embolization, the liver graft function test results remained within normal limits without HAP recurrence.

Conclusions
HAP at the CHA after liver transplantation can be fatal if ruptured. Because the liver is a highly angiogenic organ, even if initial treatment is not successful, radical treatment to occlude the CHA with HAP is possible if sufficient collateral vessels are developed.
Tubular intestinal duplication extending from the stomach to the ileum associated with multiple intestinal atresia and situs inversus: a case report
Authors: Higashidate Naruki , Sakamoto Saki , Saikusa Nobuyuki , Koga Yoshinori , Masui Daisuke , Nakahara Hirotomo , Nakamura Misa , Saikusa Mamoru , Kinoshita Masahiro , Kaji Tatsuru 
Published: August 2023

Abstract
Background
Duplication of the alimentary tract can occur in any of its parts. For duodenal duplication, complete resection is particularly difficult when the ampulla of Vater is on the duplicated lumen and a deliberate management is necessary.

Case presentation
A 0-day female baby was referred to our department due to abdominal distention. The X-ray examination showed dextrocardia and opacity of the liver on the left side and abdominal ultrasonogram revealed remarkable intestinal dilatation. Therefore, urgent laparotomy was performed on the day of birth. Complete situs inversus of the abdominal organs was revealed, and the origin of the jejunum was on the left side and was accompanied by tubular intestinal duplication. The origin of the duplicated intestine was at the pancreatic head’s dorsal area. There were two points of type Шa atresia on the ileum. Therefore, we spared the duplicated intestine with a length of 3 cm to secure the passage of the biliary and pancreatic juices by a functional-side-to-side anastomosis with a 45-mm Endo-GIA™ camel load (Medtronic, Minneapolis, MN, USA). The ileum was transected at the distal side of the atresia point, and end-to-end jejunoileostomy was performed. Postoperative gastrointestinal series revealed remnants of the duplicated alimentary tract on the dorsal area of the stomach.

Conclusions
Identifying the position of the ampulla of Vater is crucial in the surgery of alimentary tract duplication with duodenal involvement. However, in the present case, it was difficult to identify whether the ampulla of Vater was on the true or duplicated lumen, and we had to spare the duplicated duodenum. Stapler anastomosis could be performed safely even in neonatal cases.
Hypnosis to reduce fear of falling in hospitalized older adults: a feasibility randomized controlled trial
Authors: Cuvelier Clémence , Hars Mélany , Zamorani-Bianchi Maria Pia , Herrmann François R. , Wieczorkiewicz Catherine Ducharne , Zekry Dina , Gold Gabriel , Trombetti Andrea 
Published: August 2023

Abstract
Background
Fear of falling is associated with numerous negative health outcomes in older adults and can limit the rehabilitation process. Hypnosis is now recognized as an effective treatment for a variety of conditions, especially anxiety and pain, which can be integrated safely with conventional medicine. The objective of this study was to assess the feasibility and acceptability of a hypnosis intervention in hospitalized older adults to reduce fear of falling.

Methods
In this feasibility randomized controlled trial, 32 older patients, hospitalized in geriatric rehabilitation wards, were randomly allocated (1:1 ratio) to either an intervention group (hypnosis, 2 sessions, one per week, plus usual rehabilitation program) or a control group (usual rehabilitation program only). Clinical assessors and statistician were blinded to group allocation. Primary outcomes were recruitment rate, retention rate, and adherence to the intervention. Exploratory outcomes, analyzed according to the intention-to-treat principle, included impact of hypnosis on fear of falling (assessed by a new scale perform-FES), functional status, in-hospital falls, and length of hospital stay.

Results
Recruitment rate was 1.3 patients per week. The recruitment of the population sample was achieved in 5.5 months. The retention rate did not differ significantly between groups and a good adherence to the hypnosis intervention was achieved (77% of patients received the full intervention). No adverse event related to the hypnosis intervention was observed. Regarding exploratory clinical outcomes, no differences were found between groups on any outcome.

Conclusion
Hypnosis is feasible and well accepted in a geriatric hospitalized population undergoing rehabilitation. Further pilot work should be conducted, with an increased number of hypnosis sessions, before conducting a full-scale trial to conclude whether, or not, hypnosis is effective to reduce fear of falling.

Trial registration
NCT04726774.
Development and validation of a simulation-based assessment tool in colonoscopy
Authors: Jaensch Claudia , Jensen Rune D. , Paltved Charlotte , Madsen Anders H. 
Published: August 2023

Abstract
Background
Colonoscopy is difficult to learn. Virtual reality simulation training is helpful, but how and when novices should progress to patient-based training has yet to be established. To date, there is no assessment tool for credentialing novice endoscopists prior to clinical practice. The aim of this study was to develop such an assessment tool based on metrics provided by the simulator. The metrics used for the assessment tool should be able to discriminate between novices, intermediates, and experts and include essential checklist items for patient safety.

Methods
The validation process was conducted based on the Standards for Educational and Psychological Testing. An expert panel decided upon three essential checklist items for patient safety based on Lawshe’s method: perforation, hazardous tension to the bowel wall, and cecal intubation. A power calculation was performed. In this study, the Simbionix GI Mentor II simulator was used. Metrics with discriminatory ability were identified with variance analysis and combined to form an aggregate score. Based on this score and the essential items, pass/fail standards were set and reliability was tested.

Results
Twenty-four participants (eight novices, eight intermediates, and eight expert endoscopists) performed two simulated colonoscopies. Four metrics with discriminatory ability were identified. The aggregate score ranged from 4.2 to 51.2 points. Novices had a mean score of 10.00 (SD 5.13), intermediates 24.63 (SD 7.91), and experts 30.72 (SD 11.98). The difference in score between novices and the other two groups was statistically significant (p<0.01). Although expert endoscopists had a higher score, the difference was not statistically significant (p=0.40). Reliability was good (Cronbach’s alpha=0.86). A pass/fail score was defined at 17.1 points with correct completion of three essential checklist items, resulting in three experts and three intermediates failing and one novice passing the assessment.

Conclusion
We established a valid and reliable assessment tool with a pass/fail standard on the simulator. We suggest using the assessment after simulation-based training before commencing work-based learning.
Effectiveness of music-based interventions for cognitive rehabilitation in Parkinson’s disease: a systematic review of randomized controlled clinical trials
Authors: Citon Leonardo Francisco , Hamdan Amer Cavalheiro 
Published: August 2023

Abstract
Background
Music-based interventions are promising for cognitive rehabilitation in Parkinson’s disease; however, systematic reviews covering the topic are scarce.

Objective
To analyze the effectiveness of music-based interventions for cognitive rehabilitation in PD.

Method
Systematic review study based on PRISMA criteria. The descriptors Parkinson’s disease, Parkinson’s disease, idiopathic Parkinson’s disease, music-based interventions, music therapy, music training, auditory stimulation, music, rhythm, rhythmic, cognition, and cognitive were used. Five databases were searched PubMed/MEDLINE, PsycInfo, Scopus, Web of Science, and Cochrane in May 2022. Only randomized controlled trials with no limit on publication date or language were included. Risk of bias was assessed following Cochrane Collaboration criteria for development of systematic intervention reviews.

Results
Nine hundred nineteen articles were found by the descriptors; 266 were excluded for being repeated; 650 for not meeting the inclusion criteria. The remaining three articles were included and analyzed. The interventions consisted of practices with emphasis on rhythm and were conducted in groups. Risks of important biases were observed, such as lack of blinding in the allocation of participants and in the assessment of outcomes, as well as incomplete data for some outcomes.

Conclusion
Overall, the results showed no evidence of efficacy of music-based interventions for cognitive outcomes in PD.
Toxic effect of cyanobacterial (blue–green algae) extracts as natural pesticides for the control of Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae)
Authors: Sharanappa C. H. , Bheemanna M. , Prabhuraj A. , Harischandra R. Naik , Nagaraj M. Naik , Saroja N. Rao , Kariyanna B. 
Published: August 2023

AbstractBackgroundTheSpodoptera frugiperda(J. E. Smith) (Lepidoptera: Noctuidae) is a cosmopolitan polyphagous pest that feeds on nearly 80 species of plants The pest can cause upto 100% damage to crops if neglected. It is also resistant to the most of the chemical molecules available in the market, so it is necessary to identify alternate technology to combat this pest.ResultsThe crude cyanobacterial extracts of hexane, petroleum ether, ethanol and methanol extracts ofSpirulinasp. andNostoc muscorumwere evaluated against second instar larvae ofS. frugiperdathrough diet overlay method of bioassay. The results revealed thatN. muscorumhexane extract andN. muscorumpetroleum ether extract recorded the lowest LC50value of 49.09 and 61.37 ppm, respectively. This was followed bySpirulinahexane extract,Spirulinapetroleum ether extract,N. muscorumethanol extract,N. muscorummethanol extract,Spirulinaethanol and methanol extract which were recorded 173.16, 227.22, 530, 730, 970 and 1000 ppm, respectively. Further, their potential effects on different biological parameters ofS. frugiperda,viz. larval duration, pupal duration, percent pupation, pupal weight, pupal malformation, adult malformation, percent adult emergence, fecundity, and male and female adult longevity, were studied. The significant effects on different biological parameters were recorded byN. muscorumhexane and petroleum ether extract, followed bySpirulinahexane and petroleum ether extract. Similarly, an experiment was repeated for the confirmation of the first set of results, which followed by a similar trend. The first-ever novel study onS. frugiperdaconcluded that crude extracts ofSpirulinasp. andN. muscorumextracts showed significant effects in causing larval mortality and affecting different biological parameters.ConclusionsThe experimental results can be recommended as a potential source of natural pesticides for the control ofS. frugiperda.
Static and natural frequency investigation of FGP beams considering thermal effects and design parameters
Authors: Azizzadeh Arsalan , Behjat Bashir 
Published: August 2023

AbstractThis study presents a static analysis and natural frequency analysis of functionally graded laminated piezoelectric beams based on the Euler–Bernoulli theory using the finite element method. A simple power law is used to vary all material properties across the thickness, except for Poisson’s ratio. The effect of laminate configuration and volume fraction index on the deflection and natural frequency of beams made of functionally graded piezoelectric materials (FGPM) is investigated, and the relationship between deflection and different volume fraction indices under thermal, electrical, and mechanical loads is explored. The study shows that there is a certain volume fraction index that maximizes or minimizes deflection. Additionally, the variation of natural frequency in relation to the power law index is examined. The findings of this research are useful for the development of sensors and actuators in different environments, and the appropriate operation point of the structure can be selected based on the behavior of the sensor or actuator of the beam.
The barriers and facilitators to young people’s engagement with bidirectional digital sexual health interventions: a mixed methods systematic review
Authors: Bennett Clare , Musa Massirfufulay Kpehe , Carrier Judith , Edwards Deborah , Gillen Elizabeth , Sydor Anna , Dunn Catherine , Jones-Mahoney Kaye , Nute Alex , Kelly Daniel 
Published: August 2023

Abstract
Background
Sexual health is fundamental to the overall health and wellbeing of individuals and to the social and economic development of communities and countries. However, internationally young people endure a disproportionate burden of sexually transmitted infections and unintended pregnancies which can be associated with poor psycho-social outcomes. Digital sexual health interventions have been developed to increase young people’s access to sexual health services, but are currently underutilised.

Aim
This systematic review sought to identify the barriers and facilitators to young people’s engagement with bidirectional digital sexual health interventions, which are standalone two-way tailored interventions between a young person and healthcare professional.

Methods
The review was conducted in accordance with the JBI methodology for mixed methods systematic reviews, following a convergent integrated approach to synthesis and integration of qualitative and quantitative evidence. Searches of ten electronic databases were conducted, spanning database inception to January 2022. No restrictions were imposed on language, geographical location or community setting. All included studies were critically appraised with JBI Critical Appraisal tools. Data extraction was performed using standardised tools, followed by data transformation. Data synthesis followed the convergent integrated approach. Each stage was conducted by two independent reviewers.

Results
Eight thousand four hundred thirty-nine titles and abstracts and, subsequently, 255 full-texts underwent review. Nine studies were selected for inclusion with no studies added following forward and backward citation tracking. The included studies comprised three qualitative and six quantitative designs. Three meta synthesised findings were identified: (1) The design of a digital intervention for adolescent sexual health needs to reflect the end users’ specific needs (2) Young people need to feel comfortable when using a digital sexual health intervention (3) Potential barriers to engagement need to be addressed. The review identified that although barriers and facilitators to promoting young people’s engagement with bidirectional digital sexual health interventions are nuanced, young people’s privacy and security need to be prioritised for them to engage with digital interventions, regardless of the platform of choice.

Conclusions
Co-production of digital sexual health services, in partnership with young people, has shaped many of the insights reported in this systematic review. Further international research which places an emphasis on young people’s perspectives is vital to unleash the full potential of digital technology in this domain.
Primary Adrenal Insufficiency Masked by an Eating Disorder Diagnosis in an Adolescent Male
Authors: Nichols Presley , Rahming Virginia , Weiner Alyson , Sopher Aviva B 
Published: August 2023

Abstract
We describe a 14-year-old male who was followed for several years for the diagnoses of avoidant restrictive food intake disorder and generalized anxiety disorder before being diagnosed with primary adrenal insufficiency (PAI) or Addison disease. The patient presented multiple times to different facilities with worsening symptoms of anorexia, nausea, vomiting, and anxiety in the months leading up to diagnosis of PAI. Dehydration and hypotension, occurring relatively late in the course of his illness, were attributed to poor intake and vomiting. Hyponatremia was attributed to his psychotropic medication, olanzapine, and to dehydration. During his third hospitalization, he was diagnosed with PAI; treatment with stress-dose glucocorticoid therapy resulted in rapid clinical improvement. This case serves as a reminder that adrenal insufficiency must be considered in the differential diagnosis of eating disorders because signs and symptoms of adrenal insufficiency can overlap and progress insidiously. Additionally, we recognize that the diagnostic process is intertwined with a patient's medical history and use this opportunity to discuss cognitive, specifically anchoring, bias in academic medicine.