bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting the state of synchronization of financial time series using cross recurrence plots
Authors: Shabani Mostafa , Magris Martin , Tzagkarakis George , Kanniainen Juho , Iosifidis Alexandros 
Published: June 2023

AbstractCross-correlation analysis is a powerful tool for understanding the mutual dynamics of time series. This study introduces a new method for predicting the future state of synchronization of the dynamics of two financial time series. To this end, we use the cross recurrence plot analysis as a nonlinear method for quantifying the multidimensional coupling in the time domain of two time series and for determining their state of synchronization. We adopt a deep learning framework for methodologically addressing the prediction of the synchronization state based on features extracted from dynamically sub-sampled cross recurrence plots. We provide extensive experiments on several stocks, major constituents of the S &P100 index, to empirically validate our approach. We find that the task of predicting the state of synchronization of two time series is in general rather difficult, but for certain pairs of stocks attainable with very satisfactory performance (84% F1-score, on average).
Clavicular bone defects managed with free vascularised fibular grafting: evidence to date
Authors: Wakefield Sophia M. , Giannoudis Vasileios P. , Giannoudis Peter V. 
Published: June 2023

AbstractReconstructive surgery of the clavicle using free vascularised fibula grafting (FVFG) is sometimes required for the management of severe bone loss or non-union. As the procedure is relatively rare, there is no universal agreement on the management and outcome. This systematic review aimed to first, identify the conditions for which FVFG has been applied; second, to gain an understanding of the surgical techniques used; and third, to report outcomes related to bone union, infection eradication, function and complications. A PRISMA strategy was used. Medline, Cochrane Central Register of Controlled Trials, Scopus and EMBASE library databases were interrogated using pre-defined MeSH terms and Boolean operators. Quality of evidence was evaluated based on OCEBM and GRADE systems. Fourteen studies based on 37 patients were identified with a mean follow-up time of 33.3 months. The most common reasons for the procedure were: fracture non-union; tumours requiring resection; post-radiation treatment osteonecrosis and osteomyelitis. The operation approaches were similar, involving graft retrieval, insertion and fixation and vessels chosen for reattachment. The mean clavicular bone defect size was 6.6 cm (± 1.5), prior to FVFG. Bone union occurred in 94.6% with good functional outcomes. Complete infection eradication occurred in those with preceding osteomyelitis. The main complications were broken metalwork, delayed union/non-union and fibular leg paraesthesia (n = 20). The mean re-operation number was 1.6 (range 0–5.0). The study demonstrates that FVFG is well tolerated and has a high success rate. However, patients should be advised about complication development and re-intervention requirement. Interestingly, overall data is sparse with no large cohort groups or randomised trials.
Response in axillary lymph nodes to neoadjuvant chemotherapy for breast cancers: correlation with breast response, pathologic features, and accuracy of radioactive seed localization
Authors: Clark Beth Z. , Johnson Ronald R. , Berg Wendie A. , McAuliffe Priscilla , Bhargava Rohit 
Published: June 2023

Abstract
Objectives
This study examined the accuracy of radioactive seed localization (RSL) of lymph nodes (LNs) following neoadjuvant chemotherapy (NAC) for invasive breast carcinoma, recorded pathologic features of LNs following NAC, evaluated concordance of response between breast and LNs, and identified clinicopathologic factors associated with higher risk of residual lymph node involvement.

Methods
Clinical records, imaging, and pathology reports and slides were retrospectively reviewed for 174 breast cancer patients who received NAC. Chi-square and Fisher’s exact tests were used to compare differences in risk of residual lymph node disease.

Results
Retrieval of biopsied pre-therapy positive LN was confirmed in 86/93 (88%) cases overall, and in 75/77 (97%) of cases utilizing RSL. Biopsy clip site was the best pathologic feature to confirm retrieval of a biopsied lymph node. Pre-therapy clinical N stage > 0, positive pre-therapy lymph node biopsy, estrogen and progesterone receptor positivity, Ki67 < 50%, HR + /HER2− tumors, and residual breast disease had higher likelihood of residual lymph node disease after NAC (p < 0.001).

Conclusions
RSL-guided LN excision improves retrieval of previously biopsied LNs following NAC. The pathologist can use histologic features to confirm retrieval of targeted LNs, and tumor characteristics can be used to predict a higher risk of residual LN involvement.
Educational Participatory Design in the Crossroads of Histories and Practices – Aiming for Digital Transformation in Language Pedagogy
Authors: Kinnula Marianne , Iivari Netta , Kuure Leena , Molin-Juustila Tonja 
Published: June 2023

AbstractSome level of digital technology design skills and competencies is important in any profession but in their education and work life this is often ignored. We explore the potential of Educational Participatory Design (EPD) in transforming work practices within diverse disciplines. This is done through a transdisciplinary case where EPD was used as an approach for transforming language teacher education seen to respond too slowly to technological advancements in society and work life. Based on our findings, we propose EPD as a useful approach for building the design agency of future professionals with various disciplinary and professional backgrounds. In the context of real-life work practice with students as future workers, EPD invites them to act as ‘designers’ envisioning novel practices and technologies for their own work, engaging their ‘users’ in the PD processes. EPD as a novel methodological approach integrates design with work practice learning and education and therefore, we suggest, belongs to the core expertise of CSCW research and design interested in the digital transformation of work practices.
Rotation invariant GPS trajectory mining
Authors: Leodolter Maximilian , Plant Claudia , Brändle Norbert 
Published: June 2023

AbstractMining of GPS trajectories of moving vehicles and devices can provide valuable insights into urban systems, planning and operational applications. Understanding object motion often requires that the spatial-temporal matching of trajectories be invariant to shifting, scaling and rotation. To this end, Procrustes analysis enables to transform one data set of a trajectory to represent another set of data as closely as possible. We propose a novel shift-scale-rotation invariant Procrustes distance metric based on the Kabsch algorithm, which calculates the optimal rotation matrix by minimizing the root-mean squared deviation between two paired sets of points of trajectories or trajectory segments. We present two novel runtime efficient algorithms which are based on our proposed distance metric: 1) the sliding-shifting-scaling-Kabsch-rotation (S3KR) algorithm for detecting recurring short query patterns in longer motion trajectories and 2) a novel time series subsequence clustering algorithm to group GPS trajectory data and to discover prototypical patterns. We demonstrate the potential of our proposed sliding Procrustes analysis algorithms by applying it on real-world GPS trajectories collected in urban and rural areas from different transport modes, as well as on nautical GPS trajectories. We also demonstrate that our methods outperform the state of the art in accuracy and runtime on synthetic and real world data.
Suicidal Risk and Depression in Pregnant Women in Times of Pandemic
Authors: Solis Mirta , Valverde-Barea Mercedes , Gutiérrez-Rojas Luis , Romera Inmaculada , Cruz-Bailén Sheila , Jiménez-Fernández Sara 
Published: June 2023

Abstract
Purpose
Pregnancy is a risk period for the development of mental disorders. About 10% of pregnant women worldwide experience a mental disorder, mainly depression, and this percentage has been aggravated by the COVID-19 pandemic. This study aims to understand the impact of COVID-19 on the mental health of pregnant women.

Methods
Three hundred and one pregnant women in the week 21.85 ± 9.9 were recruited through social media and pregnant women forums from September 2020 to December 2020. A multiple-choice questionnaire was administered to evaluate the sociodemographic characteristics of the women, the care provided, and different aspects related to COVID-19. A Beck Depression Inventory was also delivered.

Results
Of the pregnant women 23.5% had seen or had considered seeing a mental health professional during pregnancy. Predictive models using multivariate logistic regression found that this fact was associated with an increased risk of depression (OR = 4.22; CI 95% 2.39–7.52; P < 0.001). Among women with moderate-severe depression, it was associated with an increased risk of having suicidal thoughts (OR = 4.99; CI 95% 1.11–27.9; P = 0.044) and age was found to be a protective variable (OR = 0.86; CI 95% 0.72–0.98; P = 0.053).

Conclusions
The COVID-19 pandemic represents a major mental health challenge for pregnant women. Despite the decrease in face-to-face visits, there are opportunities for health professionals to identify the existence of psycho-pathological alterations and suicidal ideation by asking the patient if she is seeing or considering seeing a mental health professional. Therefore, it is necessary to develop tools for early identification to ensure correct detection and care.
Luvadaxistat: A Novel Potent and Selective d-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia
Authors: Fradley Rosa , Goetghebeur Pascal , Miller David , Burley Russell , Almond Sarah , Gruart i Massó Agnès , Delgado García José M. , Zhu Bin , Howley Eimear , Neill Jo C. , Grayson Ben , Gaskin Philip , Carlton Mark , Gray Ian , Serrats Jordi , Davies Ceri H. 
Published: June 2023

AbstractN-methyl-d-aspartate (NMDA) receptor hypofunctionality is a well-studied hypothesis for schizophrenia pathophysiology, and daily dosing of the NMDA receptor co-agonist, d-serine, in clinical trials has shown positive effects in patients. Therefore, inhibition of d-amino acid oxidase (DAAO) has the potential to be a new therapeutic approach for the treatment of schizophrenia. TAK-831 (luvadaxistat), a novel, highly potent inhibitor of DAAO, significantly increases d-serine levels in the rodent brain, plasma, and cerebrospinal fluid. This study shows luvadaxistat to be efficacious in animal tests of cognition and in a translational animal model for cognitive impairment in schizophrenia. This is demonstrated when luvadaxistat is dosed alone and in conjunction with a typical antipsychotic. When dosed chronically, there is a suggestion of change in synaptic plasticity as seen by a leftward shift in the maximum efficacious dose in several studies. This is suggestive of enhanced activation of NMDA receptors in the brain and confirmed by modulation of long-term potentiation after chronic dosing. DAAO is highly expressed in the cerebellum, an area of increasing interest for schizophrenia, and luvadaxistat was shown to be efficacious in a cerebellar-dependent associative learning task. While luvadaxistat ameliorated the deficit seen in sociability in two different negative symptom tests of social interaction, it failed to show an effect in endpoints of negative symptoms in clinical trials. These results suggest that luvadaxistat potentially could be used to improve cognitive impairment in patients with schizophrenia, which is not well addressed with current antipsychotic medications.
Moral foundations theory and the narrative self: towards an improved concept of moral selfhood for the empirical study of morality
Authors: van den Berg Tom Gerardus Constantijn , Corrias Luigi Dennis Alessandro 
Published: June 2023

AbstractWithin the empirical study of moral decision making, people’s morality is often identified by measuring general moral values through a questionnaire, such as the Moral Foundations Questionnaire provided by Moral Foundations Theory (MFT). However, the success of these moral values in predicting people’s behaviour has been disappointing. The general and context-free manner in which such approaches measure moral values and people’s moral identity seems crucial in this respect. Yet, little research has been done into the underlying notion of self. This article aims to fill this gap. Taking a phenomenological approach and focusing on MFT, we examine the concept of moral self that MFT assumes and present an improved concept of moral self for the empirical study of morality. First, we show that MFT adopts an essentialist concept of moral self, consisting of stable moral traits. Then, we argue that such a notion is unable to grasp the dynamical and context sensitive aspects of the moral self. We submit that Ricoeur’s narrative notion of identity, a self that reinterprets itself in every decision situation through self-narrative, is a viable alternative since it is able to incorporate context sensitivity and change, while maintaining a persisting moral identity. Finally, we argue that this narrative concept of moral self implies measuring people’s morality in a more exploratory fashion within a delineated context.
‘Experience’, ordinary and philosophical: a corpus study
Authors: Sytsma Justin , Fischer Eugen 
Published: June 2023

AbstractCommon arguments for realism about phenomenal consciousness contend that this is a folk concept, with proponents expecting it to be lexicalised in ordinary language. In English, the word ‘experience’ is typically regarded as the best candidate. This predicts that ‘experience’ will be used to refer to mental states and episodes, not only in philosophical but also in ordinary discourse. We conduct a corpus study in order to assess this claim and to understand the actual use of the word in non-academic, academic, and philosophical discourse. In non-academic discourse, uses that refer to knowledge or sources of knowledge, and to public events, are found to dominate. Uses that refer to mental states or episodes dominate only in the philosophy of mind (and not even in philosophy at large).
The potential role of micro-RNA 125b-5p level in predicting outcome from thrombolytic therapy in patients with acute ischemic stroke
Authors: Mostafa Sara , Al Masry Hatem , Hussein Mona , Abd Elkareem Rehab M. , Masoud Mohammed M. 
Published: June 2023

AbstractSeveral studies highlighted a significant role of specific miRNA as diagnostic and prognostic biomarkers for acute ischemic stroke. The aim of this work was to study micro-RNA 125b-5p level in patients with acute ischemic stroke in relation to stroke etiology, risk factors, severity and outcome. This case–control study was conducted on 40 patients with acute ischemic stroke eligible for receiving rt-PA and 40 age and sex matched healthy controls, Patients were submitted to neurological and radiological assessment. Functional outcome after 3 months was assessed using the modified Rankin Scale (mRS). Plasma micro-RNA 125b-5p levels were measured for both patients and control groups by quantitative real time PCR. MiRNA-125b-5p was extracted from the plasma samples then Real-time quantitative reversed transcription PCR (RT-qPCR) analysis was done. To analyze miRNA-125b-5p expression in plasma, the ∆Cq value of miRNA-125b-5p was calculated by subtracting Cq of miRNA-125b-5p from the average Cq of MiRNA RNU6B.
Stroke patients had significantly higher circulating micro-RNA 125b-5p levels in comparison to healthy controls (P value = 0.01). The circulating levels of micro-RNA 125b-5p were positively correlated with stroke severity assessed by National Institutes of Health Stroke Scale (NIHSS) and infarction size. Stroke patients with poor outcome had significantly higher circulating levels of micro-RNA 125b-5p in comparison to those with good outcome (P value ≤ 0.001). The circulating levels of micro-RNA 125b-5p were significantly higher in patients who developed complications after receiving rt-PA (P value ≤ 0.001). Logistic regression model revealed that each unit increase in micro-RNA125b-5p decreased the odds of good outcome by 0.095 (95% CI 0.016–0.58, P value = 0.011). Plasma micro-RNA 125b-5p is significantly elevated is ischemic stroke patients. It is positively correlated with stroke severity and strongly associated with poor outcome and complications after thrombolytic therapy.
Turkey adenovirus 3: ORF1 gene sequence comparison between vaccine-like and field strains
Authors: Quaglia Giulia , Di Francesco Antonietta , Catelli Elena , Mescolini Giulia , Lupini Caterina 
Published: June 2023

AbstractHaemorrhagic enteritis is an economically significant disease reported in the majority of the countries where turkeys are raised intensively; it is caused by Turkey adenovirus 3 (TAdV-3). The aim of this study was to analyse and compare the ORF1 gene 3′ region from turkey haemorrhagic enteritis virus (THEV) vaccine-like and field strains in order to develop a molecular diagnostic method to differentiate the strains from each other. Eighty samples were analysed by sequencing and phylogenetic analyses using a new set of polymerase chain reaction (PCR) primers targeting a genomic region spanning the partial ORF1, hyd and partial IVa2 gene sequences. A commercial live vaccine was also included in the analysis. The results showed that 56 of the 80 sequences obtained in this study showed ≥99.8% nucleotide identity with the homologous vaccine strain sequence. Three non-synonymous mutations – ntA1274G (aaI425V), ntA1420C (aaQ473H) and ntG1485A (aaR495Q) – were detected in the THEV field strains but not in the vaccine strain. Phylogenetic analysis confirmed the clustering of the field and vaccine-like strains in different phylogenetic branches. In conclusion, the method employed in this study could be a useful tool towards making a correct diagnosis. The data could contribute to the knowledge of field distribution of THEV strains and increase the limited existing information available on native isolates around the world.
Die paradoxe Wirkung von Altersbildern auf das Alters- und Gesundheitserleben älterer Menschen – Befunde einer quantitativen und qualitativen Studienreihe
Authors: Wangler Julian , Jansky Michael 
Published: June 2023

Zusammenfassung
Hintergrund
Öffentlich zirkulierende Altersbilder spielen eine zentrale Rolle für Verhaltenszuschreibungen in Bezug auf ältere Menschen sowie die individuelle Wahrnehmung des Alterungsprozesses. Bislang fehlt es an Erkenntnissen, inwieweit Altersbilder sich auf das Alters- und Gesundheitserleben sowie Selbstkonzepte älterer Menschen auswirken können.

Ziel der Arbeit
Die Studienreihe hat ältere Proband*innen kontrolliert mit prototypischen medialen Altersdarstellungen konfrontiert. Es wurden Auswirkungen auf Einstellungen zum Alter und persönliches Älterwerden ermittelt. Von Interesse war, inwiefern die Konfrontation mit dem Stimulusmaterial Auswirkungen auf das Empfinden von Älterwerden, Gesundheit und Körperlichkeit zeigt.

Material und Methoden
Aufbauend auf einer inhaltsanalytischen Vorstudie wurden im Jahr 2020 insgesamt 910 Proband*innen ab 60 Jahre im Rahmen einer quasiexperimentellen Befragung mit unterschiedlichen Altersframes konfrontiert. Ergänzend wurden im Jahr 2022 insgesamt 36 fokussierte Interviews mit älteren Menschen geführt, denen jeweils ein Stimulus in Form eines Artikels vorgelegt wurde, der Alter und Älterwerden in spezifischer Weise präsentiert.

Ergebnisse
Die Ergebnisse belegen, dass die Rezeption eines negativen Altersframes zu einer Verbesserung des Selbstbildes älterer Menschen führt. Die Rezeption des positiven Altersframes führt hingegen zu einer Verschlechterung des Selbstbildes. Im Zuge der Interviews wurde deutlich, dass die Konfrontation mit einer positiv überhöhten Altersdarstellung bei den Befragten zu Unsicherheit, Stress und Selbstzweifeln führte. Die Hälfte der Befragten stellte fest, die Anforderungen an ein „modernes“ Altern nicht erfüllen zu können und fühlte sich entsprechend schlecht.

Schlussfolgerung
Mediale Altersdarstellungen zeigen komplexe und scheinbar paradoxe Wirkungen. So treten negative Effekte für das Selbst- und Alterserleben bei älteren Menschen auf, wenn eine Altersdarstellung einseitig positiv ausfällt. Es kann vermutet werden, dass hierbei soziale Vergleichsprozesse stattfinden. Insgesamt bestätigt die Studienreihe, dass Altersbilder in ihren Auswirkungen auf die Wahrnehmung von Alterungs- und Gesundheitsprozessen hoch relevant sind.
Governance by Uncertainty: Changing Patterns in China’s Environmental Enforcement
Authors: van der Kamp Denise Sienli 
Published: June 2023

AbstractGovernance in China is often characterized as dualistic. On the one hand, the state invests in stable, rule-based institutions to support effective policy implementation. Yet the state also engages in sudden regulatory campaigns, overstepping its own laws to implement rapid changes in key sectors. Businesses in China have developed coping mechanisms to weather these uncertainties; they cultivate political ties or learn to accommodate unexpected disruptions. Yet in the sphere of environmental policy implementation, businesses across the spectrum are starting to complain that local environmental enforcement feels unpredictable, even arbitrary. What constitutes unpredictable enforcement in an environment already characterized by high levels of regulatory uncertainty? What changes in environmental enforcement are driving these complaints? Using original data on nine years of city-level enforcement measures, I show that both campaign-style and rule-based enforcement have been increasing in intensity and frequency since the mid-2010s. Through qualitative evidence, I show how these two approaches work at cross purposes, generating mixed signals on which strategies businesses should use to reduce pollution or to mitigate regulatory uncertainty. Data shows that this is a nationwide pattern, which explains why business—even experienced, well-connected businesses—are complaining about arbitrary state action. This study draws attention to emerging stress tests of China’s dualistic governance, while delving into what these changes portend for state-business relations in China.
On curves on Hirzebruch surfaces
Authors: Martens Gerriet 
Published: June 2023

AbstractWe call a smooth irreducible projective curve a Castelnuovo curve if it admits a birational map into the projective r-space such that the image curve has degree at least 2r+1 and the maximum possible geometric genus (which one can calculate by a classical formula due to Castelnuovo). It is well known that a Castelnuovo curve must lie on a Hirzebruch surface (rational ruled surface). Conversely, making use of a result of W. Castryck and F. Cools concerning the scrollar invariants of curves on Hirzebruch surfaces we show that curves on Hirzebruch surfaces are Castelnuovo curves unless their genus becomes too small w.r.t. their gonality. We analyze the situation more closely, and we calculate the number of moduli of curves of fixed genus g and fixed gonality k lying on Hirzebruch surfaces, in terms of g and k.