bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling
Authors: Danhof Heather A. , Lee Jihwan , Thapa Aanchal , Britton Robert A. , Di Rienzi Sara C. 
Published: March 2023

AbstractIntestinal microbes impact the health of the intestine and organs distal to the gut.Limosilactobacillus reuteriis a human intestinal microbe that promotes normal gut transit1, the anti-inflammatory immune system2–4, wound healing5–7, normal social behavior in mice8–10, and prevents bone reabsorption11–17. Each of these functions is impacted by oxytocin18–22, and oxytocin signaling is required forL. reuteri-mediated wound healing5and social behavior9; however, the initiating events in the gut that lead to oxytocin stimulation and related beneficial functions remain unknown. Here we found evolutionarily conserved oxytocin production in the intestinal epithelium through analysis of single-cell RNA-Seq datasets and imaging of human and mouse intestinal tissues. Moreover, human intestinal organoids produce oxytocin, demonstrating that the intestinal epithelium is sufficient to produce oxytocin. We subsequently found thatL. reuterifacilitates oxytocin secretion directly from human intestinal tissue and human intestinal organoids. Finally, we demonstrate that stimulation of oxytocin secretion byL. reuteriis dependent on the gut hormone secretin, which is produced in enteroendocrine cells23, while oxytocin itself is produced in enterocytes. Altogether, this work demonstrates that oxytocin is produced and secreted from enterocytes in the intestinal epithelium in response to secretin stimulated byL. reuteri. This work thereby identifies oxytocin as an intestinal hormone and provides mechanistic insight into avenues by which gut microbes promote host health.
An Acoustically Controlled Microrobot Modelled onSpirocheteBacteria
Authors: Deng Yong , Paskert Adrian , Zhang Zhiyuan , Wittkowski Raphael , Ahmed Daniel 
Published: March 2023

ABSTRACTAs a next-generation toolkit, microrobots can transform a wide range of fields, including micromanufacturing, electronics, microfluidics, tissue engineering, and medicine. While still in their infancy, acoustically actuated wireless microrobots are becoming increasingly attractive, as acoustic control can generate large propulsive forces, requires relatively simple microrobot design, and does not entail complex manipulation systems. However, the interaction of acoustics with microstructure geometry is poorly understood to date, and its study is necessary for developing next-generation acoustically powered microrobots. We present here a mass-manufactured acoustically driven helical microrobot capable of locomotion using a fin-like double-helix microstructure. This microrobot responds to sound stimuli and mimics the spiral motion of natural microswimmers such as spirochetes. The asymmetric double helix interacts with the incident acoustic field, inducing a propulsion torque that causes the microrobot to rotate around its long axis. Moreover, our microrobot has the unique feature of its directionality being switchable by simply tuning the acoustic frequency. We demonstrate this locomotion in 2D and 3D artificial vasculatures using a single sound source. Since ultrasound is widely used as an imaging modality in clinical settings, our robotic system can integrate seamlessly into practice; thus, our findings could contribute to the development of next-generation smart microrobots.One-Sentence SummaryWe present an acoustically driven helical microrobot capable of corkscrew-like locomotion using a double-helix microstructure.
A nanobody-based strategy for rapid and scalable purification of native human protein complexes
Authors: Stevens Taylor Anthony , Tomaleri Giovani Pinton , Hazu Masami , Wei Sophia , Nguyen Vy N. , DeKalb Charlene , Voorhees Rebecca M. , Pleiner Tino 
Published: March 2023

AbstractNative isolation of proteins in high yield and purity is a major bottleneck for analysis of their three- dimensional structure, function, and interactome. Here, we present a streamlined workflow for the rapid production of proteins or protein complexes using lentiviral transduction of human suspension cells, combined with highly-specific nanobody-mediated purification and proteolytic elution. (1) First, generation of a plasmid coding for a protein of interest fused to an N- or C- terminal GFP or ALFA peptide tag is rapidly achieved using the lentiviral plasmid toolkit we have designed. (2) Human suspension cell lines stably expressing the tagged fusion protein can be generated in <5 days using lentiviral transduction. (3) Leveraging the picomolar affinity of the GFP and ALFA nanobodies for their respective tags, proteins expressed even at low levels can be specifically captured from the resulting cell lysate in a variety of conditions, including detergents and mild denaturants. (4) Finally, rapid and specific elution of tagged or untagged proteins under native conditions is achieved within minutes at 4°C using an engineered SUMO protease. We demonstrate the wide applicability of the method by purifying multiple challenging soluble and membrane protein complexes to high purity from human cells. Our strategy is also directly compatible with many widely used GFP expression plasmids, cell lines and transgenic model organisms; is faster than alternative approaches, requiring ∼8 days from cloning to purification; and results in substantially improved yields and purity.
Beware of the watchdog! Role communication in job advertisements for management accountants
Authors: Rieg Robert , Meier Jan-Hendrik , Finckh Carmen 
Published: March 2023

PurposeJob advertisements are important means of communicating role expectations for management accountants to the labor market. They provide information about which roles are sought and expected. However, which roles are communicated in job advertisements is unknown so far.Design/methodology/approachWith a text-mining approach on a large sample of 889 job ads, the authors extract information on roles, type of firm and hierarchical position of the management accountant sought.FindingsThe results indicate an apparent mix of different role types with a strong focus on a classic watchdog role. However, the business partner role is more often sought for leadership positions or in family businesses and small- and medium-sized enterprises (SME).Research limitations/implicationsThe main limitation is the lack of an agreed-upon measurement instrument for roles in job offers. The study results imply that corporate practice is not as theory-driven as is postulated and communicated in the management accounting community. This indicates the existence of a research-practice gap and tensions between different actors in the management accounting field.Practical implicationsThe results challenge the current role discussion of professional organizations for management accountants as business partners.Originality/value The authors contribute the first study, which explicitly analyzes the communication of roles in job offers for management accountants. It indicates a discrepancy between scholarly discussion on roles and management accountants' work from an employer's perspective.
Challenge and hindrance demands of doctoral education: conceptualization, scale development and validation
Authors: Acharya Vrinda , Rajendran Ambigai , Prabhu Nandan 
Published: March 2023

PurposeThe present study develops, conceptualizes and validates a scale based on the transactional stress theory to assess the perceived challenge and hindrance demands of doctoral programs that impact doctoral students’ psychological well-being.Design/methodology/approachThis research employs an exploratory-mixed methodology comprising five phases with a sequential qualitative-quantitative approach. A rigorous scale development process is adopted to validate the instrument’s psychometric properties. The study respondents are Indian full-time doctoral students in the management discipline.FindingsThe findings show that the construct of perceived challenge and hindrance demands is a first-order four-factor and a second-order two-factor model. The study has validated the scale to capture the challenge and hindrance demands of doctoral research programs with the following sub-constructs: doctoral program resource inadequacies, doctoral program ambiguity, doctoral program workload and complexity.Practical implicationsThe recommended challenge demands and hindrance demands (CHD) scale provides a benchmark for doctoral institutes and program supervisors in focussing on research students’ perception of their doctoral education demands to reduce the strain and increase their well-being during their doctoral program journey.Originality/valueHindrance demands adversely influence the motivation resources needed for doctoral education; challenge demands positively impact the research students’ internal resources.
The effect of cause-related marketing on the green consumption attitude–behaviour gap in the cosmetics industry
Authors: Venciute Dominyka , Kazukauskaite Migle , Correia Ricardo Fontes , Kuslys Marius , Vaiciukynas Evaldas 
Published: March 2023

PurposeThe aim of the article is to analyze the effect of cause-related marketing on the attitude–behaviour gap of green consumption in the cosmetics industry. Specifically, the authors examine the relationship between attitude towards the environment, attitude towards green consumption, subjective norms of green consumption, green consumption intention, green consumption behaviour and cause-related marketing.Design/methodology/approachA cross-sectional research design was used to test the results of a random sample of 241 respondents and quantitative research was conducted using the data collected through an online questionnaire.FindingsThe research expanded the current knowledge on the effect of cause-related marketing on consumers’ green purchase behaviour and the findings suggested that green cosmetics producers and sellers should clearly define their target audience before choosing the type of cause-related marketing, as it mainly influences those consumers who have a positive attitude towards green consumption.Research limitations/implicationsThe implications of the research are relevant for marketing specialists, managers and agencies who are looking to promote green cosmetics products.Practical implicationsBefore promoting green cosmetics products, it is important to understand who the target consumer is and whether they have a positive attitude towards the environment, green consumption and also if they are affected by acquaintances’ opinions.Originality/valueThe study contributes to the already existing academic literature by providing a greater understanding of the effect of cause-related marketing on the attitude–behaviour gap of green consumption.
Parole hustle: a preliminary study on the lived experiences of females serving parole in Nelson Mandela Bay
Authors: Thornton Jessica Leigh 
Published: March 2023

Purpose
This paper aims to shift from the male offender perspective in attempts to explore the stories and lived experiences of five females on parole in Nelson Mandela Bay, as most correctional research in South Africa focuses on the male offender experience. The experiences of females are largely ignored both in terms of reform and in research, and while only a few South African studies on female criminality have emerged, little is known about the impact of incarceration and reintegration on their livelihoods.

Design/methodology/approach
This paper makes use of an ethnographic approach as the narrative follows the complex realities of females on parole to include their voice, depth and experience in the debate within the parole experiences measure framework. This study made use of five individual interviews and observations, which were complemented by existing literature.

Findings
This paper provides insights on the experiences, vulnerabilities, challenges, fears and concerns of females on parole and the relative social costs of their incarceration. The experiences allow for a deeper understanding of the shades of their experiences of powerlessness, gender-specific sexualisation and exploitation, economic vulnerability and destitution and social alienation and exclusion which uniquely influences behavioural and emotional deficits.

Research limitations/implications
Because the number of females on parole in Nelson Mandela Bay is few, this study could only interview five female offenders. Yet, as this study is ethnographic in nature, it offers a deep understanding of these five female offenders.

Practical implications
This research offers an insight into the social ills faced by female on parole. This work highlights the effects of incarceration are often felt by females long after their release since their experience of imprisonment affects their future prospects, damaging and debilitating. This paper suggests self-reclamation that could lead to positive reactions towards rehabilitative and reintegration. This research opens up the larger debate and does not offer tangible recommendations.

Originality/value
This paper fulfils an identified need to study parole amongst female offenders.
Red tourism in China: emotional experiences, national identity and behavioural intentions
Authors: Wang Jinwei , Sun Jie , Wang Guoquan , Yang Li , Zhang Yijie , Morrison Alastair M. 
Published: March 2023

Purpose
This study aims to examine the empirical linkages among emotional experiences, national identity and behavioural intentions for red tourism in China.

Design/methodology/approach
Partial least squares structural equation modelling was applied to data from two rounds of surveys of 1,095 on-site visitors to Zunyi and Yan’an, two well-known red tourism cities in China.

Findings
Emotional experiences significantly affect national identity, with positive emotions significantly affecting national identity. Positive emotions also significantly influenced behavioural intentions, national identity positively influenced behavioural intentions and national pride mediated the relationship of “positive emotion → behavioural intentions”. In addition, previous experience played a moderating role in the relationship of “positive emotion → national pride”.

Originality/value
This research produced new insights on red tourism emotional experiences by clarifying its types, connotations and influences. It contributes to a better understanding of national identity antecedents and outcomes in red tourism. Findings revealed the significant role of red tourism in cultivating national identity and provide implications for academic research and practical development of red tourism.
Paying attention to pigs: negotiating equity and equality in global environmental governance in Suau, Papua New Guinea
Authors: Pascoe Sophie , Minnegal Monica 
Published: March 2023

AbstractThe idea of ‘equity’, largely grounded in Western legal tradition, has come to permeate evaluations of what is fair and just within environmental governance programmes. But what constitutes equity in climate change and conservation projects? And does everyone affected by such projects see equity as desirable? Local encounters with global environmental governance interventions in Suau, Milne Bay Province of Papua New Guinea, provide an entry point to explore these questions. Drawing on ethnographic fieldwork with communities implicated in the Central Suau Reducing Emissions from Deforestation and Forest Degradation (REDD+) Pilot Project and in Save the Forest conservation projects, we examine tensions around conceptions of equity and equality between project proponents and local communities, as well as between individuals within those communities. By paying attention to talk about pigs in Suau, and tracing the intersections between reciprocity and trade, we explore how people negotiate equity and equality. We emphasize that this negotiation is central to Suau ideas of fairness. While the REDD+ and Save the Forest projects work to ensure ‘equitable’ distribution of benefits among supposedly equivalent actors, we show how this may actually close down possibilities for negotiation of outcomes that local people consider fair.
Assessing the difference in racial and ethnic disparities in access to and use of care between Traditional Medicare and Medicare Advantage
Authors: Gangopadhyaya Anuj , Zuckerman Stephen , Rao Nikhil 
Published: March 2023

AbstractObjectiveTest whether racial‐ethnic disparities in the access and use of care differ between Traditional Medicare (TM) and Medicare Advantage (MA).Data SourceSecondary data from the 2015–2018 Medicare Current Beneficiary Survey (MCBS).Study DesignMeasure Black‐White and Hispanic‐White disparities in access to care and use of preventive services within TM, within MA, and assess the difference‐in‐disparities between the two programs with and without controls for factors that could influence enrollment, access, and use.Data Collection/ExtractionPool 2015–2018 MCBS data and restrict to non‐Hispanic Black, non‐Hispanic White, or Hispanic respondents.Principal FindingsBlack enrollees have worse access to care relative to White enrollees in TM and MA, particularly for cost‐related measures such as not having problems paying medical bills (11–13 pp. lower for Black enrollees; p < 0.05) and satisfaction with out‐of‐pocket costs (5–6 pp. lower; p < 0.05). We find no difference in Black‐White disparities between TM and MA. Hispanic enrollees have worse access to care relative to White enrollees in TM but similar access relative to White enrollees in MA. Hispanic‐White disparities in not delaying care due to cost and not reporting problems paying medical bills are narrower in MA relative to TM by about 4 pp (significant at the p < 0.05 level) each. We find no consistent evidence that Black‐White or Hispanic‐White differences in the use of preventive services differ between TM and MA.ConclusionsAcross the measures of access and use studied here, racial and ethnic disparities in MA are not substantially narrower than in TM for Black and Hispanic enrollees relative to White enrollees. For Black enrollees, this study suggests that system‐wide reforms are required to reduce existing disparities. For Hispanic enrollees, MA does narrow some disparities in access to care relative to White enrollees but, in part, because White enrollees do not do as well in MA as they do in TM.
Subchondral insufficiency fracture of the femoral head in a patient with ankylosing spondylitis: Case report and literature review
Authors: Lee Yeo‐Jin , Kim Yong‐Gil 
Published: March 2023

AbstractSubchondral insufficiency fracture (SIF) of the femoral head occurs in patients with osteoporosis, elderly women, and renal or liver transplant recipients. Although SIF has been reported in several patients with rheumatic disease, SIF of the femoral head has not been reported in patients with ankylosing spondylitis (AS), and the association between AS and SIF has not been determined. A 48‐year‐old man with AS presented with pain in his left hip for 2 months. He had been diagnosed with AS and radiographic bilateral grade 3 sacroiliitis 11 years earlier. He had been treated with subcutaneous adalimumab 40 mg biweekly for more than 10 years, during which time his condition remained stable. This patient was obese but had no other known predisposing conditions, such as old age, overexertion, osteoporosis, steroid use, or transplantation. He had never taken steroids. X‐rays showed no specific findings, other than mild osteoarthritis in both hips. However, pelvic magnetic resonance imaging demonstrated flattening and subchondral irregularity with a large amount of bone marrow edema, confirming a diagnosis of SIF of the femoral head. Thus, even in patients with AS having no significant risk factors, SIF should be considered as part of the differential diagnosis of hip pain.
Germination, overcoming seed dormancy and endozoochory dispersal by cattle of native species from natural grassland
Authors: de Azevedo Eduardo Bohrer , Pagel Reimar , Maggio Lilian Pedroso , Chiapinotto Diego Martins , Conterato Ionara Fátima , Schneider Angelo Alberto , Schaedler Carlos Eduardo , de David Diego Bitencourt 
Published: March 2023

AbstractNatural grasslands, one of the main ecosystems worldwide, are under threat and native species are desired when addressing restoration issues. The main processes for grasslands restoration success are plant establishment and seed addition in the soil. Thus, it requires overcoming barriers that prevent germination and seed dispersal strategies. This study aimed to assess the germination potential, treatments to overcome seed dormancy and endozoochory dispersal of forage native species by cattle. Seeds from 21 native species from the four most common botanical families (Poaceae, Asteraceae, Fabaceae and Cyperaceae) were collected in a natural grassland area (Pampa Biome) and used in the experiments. Experiment I: germination under controlled conditions of all species was carried out and compared to commercial forage (Paspalum notatum cv. “Pensacola”). Experiment II: three treatments to overcome seed dormancy (mechanical and chemical scarification; priming agent) were tested in six species. Experiment III: the recovery, viability and germination of native P. notatum Flüggé and Desmodium incanum DC seeds from cattle faeces were evaluated. The results show that Paspalum umbrosum Trin. and Saccharum angustifolium Nees have high germination potential when compared to commercial forage. The treatments to overcome seed dormancy increased the germination of D. incanum, Paspalum plicatulum Michx. and Paspalum dilatatum Poir. Total seed recovery of 15% (P. notatum) and 26% (D. incanum), without affecting seed viability, show that cattle are able to supply the soil seed bank with native species. Germination potential, treatments to overcome seed dormancy and endozoochory dispersal of forage native species may be exploited in natural grassland restoration.
Analysis of the sublingual artery using contrast‐enhanced computed tomography
Authors: Takahashi Akira , Kamada Kumiko , Fukuda Naoyuki , Kudoh Keiko , Takamaru Natsumi , Kurio Naito , Sugawara Chieko , Miyamoto Youji 
Published: March 2023

AbstractIntroductionThis in vivo study aimed to clarify the position of the sublingual artery (SLA) relative to the mandibular bone and to infer the potential risk for injury during dental implant surgery.MethodsContrast‐enhanced computed tomography images of the mouth of 50 edentulous patients (100 sides) treated at Tokushima University Hospital were reviewed. Curved planar reconstructed images perpendicular to the alveolar ridge were processed and classified into molar, premolar, canine, and incisor regions. The SLA and its branches were identified, and the distance from the mandible to the SLA was measured.ResultsThe SLA was located close to the mandible (<2 mm) in the molar, premolar, canine, and incisor segments in 12.0% (95% confidence interval 5.6%–18.4%), 20.6% (12.6%–28.7%), 30.5% (21.3%–39.8%), and 41.8% (28.8%–54.9%) cases, respectively. The SLA was located within ±3 mm craniocaudally to the upper wall of the mandibular canal in the molar and premolar regions in 50% of cases and within ±5 mm craniocaudally to the mylohyoid ridge in the canine and incisor regions in the other cases, with no sex or age‐related differences. The vertical distance from the alveolar ridge to the SLA was influenced by sex and age owing to alveolar resorption, indicating that the alveolar ridge is not a reliable reference for predicting SLA position.ConclusionsAs the risk of SLA injury always exist during dental implant placement and there is no way to confirm the SLA pathways in a patient, clinicians must avoid injuring the sublingual soft tissue.