bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of biochemical, hormonal, and mineral compositions of preovulatory and cystic ovarian follicles in buffalo during the non-breeding season
Authors: Kumar Brijesh , Kumawat B.L. , Khan F.A. , Das G.K. , Maurya S.K. , Chandra P. , Vandana  , Singh Jai , Sachan Vikas , Jan M.H. , Narayanan K. 
Published: March 2023

SummaryThis study is a comparative analysis of the biochemical, hormonal, and mineral compositions of follicular fluid in preovulatory and cystic follicles of water buffalo (Bubalus bubalis). In total, reproductive tracts from 215 buffalo along with intact ovaries were collected randomly from an abattoir. The incidence of cystic conditions found in this study was 3.72% (8/215), involving the right ovary in 62.5% of instances and the left ovary in 37.5% of instances during the non-breeding season. Follicular fluid was aspirated from preovulatory follicles (12–15 mm diameter, oestrogen-active, follicular phase or stage IV corpus luteum on one of the two ovaries, n = 10) and cystic follicles (at least 20 mm diameter, no corpus luteum on any one of the two ovaries, n = 8). The follicular fluid samples were assayed for biochemical components (uric acid, creatinine, blood urea nitrogen, cholesterol, total protein, glucose, ascorbic acid, and alkaline phosphatase), hormones (progesterone, estradiol, and insulin), and minerals (calcium, magnesium, phosphorus, copper, zinc, and cobalt). Cystic follicles had greater (P < 0.05) concentrations of creatinine, blood urea nitrogen, cholesterol, progesterone, copper, zinc, and cobalt, and lesser (P < 0.05) concentrations of uric acid, glucose, ascorbic acid, estradiol, insulin, calcium, magnesium, and phosphorus compared with preovulatory follicles. These results indicated the marked differences in follicular fluid composition between preovulatory and cystic follicles in buffalo. Some of the changes were indicative of oxidative stress and disturbed steroidogenesis, two important mechanisms shown to be associated with cystic ovarian disease in various species. Further studies are warranted to investigate whether these differences are directly or indirectly involved in the formation of cystic follicles or are mere manifestations of the condition.
Early spontaneous closure of large arterial ducts in two term neonates with Ebstein anomaly after failed attempts of transcatheter closure
Authors: Haddad Raymond N. , Bonnet Damien , Malekzadeh-Milani Sophie 
Published: March 2023

AbstractIn neonatal Ebstein’s anomaly of the tricuspid valve, prolonged ductal patency in patients without anatomic pulmonary valve atresia can be deleterious. Circular shunts may develop in patients with different degrees of pulmonary and tricuspid insufficiency. Closure of the arterial duct may result in haemodynamic improvement in particular scenarios. The transcatheter approach is a valuable closure alternative despite some technical difficulties in large-sized arterial ducts and low birth weight neonates. Herein, we report on two consecutive term newborns with Ebstein’s anomaly and large arterial ducts in whom mechanical stimulus of the arterial duct during failed attempts of transcatheter closure led after two days to definitive closure followed by good clinical outcomes.
When old institutions pay off: a new entrepreneurial state in South Korea and its limit in incorporating small firms into semiconductor production
Authors: Yang Nareum , Yun Ji-Whan 
Published: March 2023

AbstractThis study discusses why South Korea has not always succeeded in the ‘entrepreneurial state’ approach – defined as policy efforts to move away from the old developmental state model to a new industrial system of innovation in which small- and medium-sized enterprises (SMEs) are incorporated – by focusing on the limitation of new semiconductor industrial policies of the former Moon Jae-in government (2017–2022). Conventionally, many scholars have exclusively ascribed this limitation to large businesses' (chaebol's) practice of in-house production. Building upon historical institutionalism and its concept of increasing returns, alternatively, we shift attention to the way the Moon government played its entrepreneurial role. We argue that, as the government sought increasing returns from the developmental state idea and institution, the likelihood of wider SME incorporation decreased. Nationalism enabled the government to control the policymaking process but made it difficult to obtain new information through policy contestation. The government depended on developmental alliance to increase policy visibility through the chaebol's capabilities, but demands of small firms were downplayed. This study proposes to construct a more theoretical framework with which to explain how the old political economy model affects new entrepreneurial goals.
Differentiating Abnormal, Normal, and Ideal Personality Profiles in Multidimensional Spaces
Authors: Gutiérrez Fernando , Peri Josep Maria , Aluja Anton , Baillés Eva , Sureda Bárbara , Gutiérrez-Zotes Alfonso , Vall Gemma , Calvo Natalia , Ferrer Marc , Cavero Myriam , Mallorquí Aida , Villamón Silvia Edo , de Alba Amanda Meliá , Rodríguez M. Ángeles Ruipérez 
Published: March 2023

Abstract: Current dimensional taxonomies of personality disorder (PD) establish that intense traits do not suffice to diagnose a disorder, and additional constructs reflecting dysfunction are required. However, traits appear able to predict maladaptation by themselves, which might avoid duplications and simplify diagnosis. On the other hand, if trait-based diagnoses are feasible, it is the whole personality profile that should be considered, rather than individual traits. This takes us into multidimensional spaces, which have their own particular – but poorly understood – logic. The present study examines how profile-level differences between normal and disordered subjects can be used for diagnosis. The Dimensional Assessment of Personality Pathology – Basic Questionnaire (DAPP-BQ) and the Personality Inventory for DSM-5 (PID-5) were administered to a community and a clinical sample each (total n = 1,925 and 3,543 respectively). Intense traits proved to be common in the general population, so empirically-based thresholds are indispensable not to take as abnormal what is at most unideal. Profile-level parameters such as Euclidean and Mahalanobis distances outperformed individual traits in predicting mental problems and equaled the performance of published measures of dysfunction or severity. Personality profiles can play a more central role in identifying disorders than is currently acknowledged, provided that adequate metrics are used.
Fully Controlled 6 Meters per Pixel Equatorial Mosaic of Mars From Mars Reconnaissance Orbiter Context Camera Images, Version 1
Authors: Robbins Stuart J. , Kirchoff Michelle R. , Hoover Rachael H. 
Published: March 2023

AbstractNASA's Mars Reconnaissance Orbiter (MRO) spacecraft has operated around Mars since March 2006. The Context Camera (CTX) aboard MRO has returned >125,000 images of Mars, mostly at 5–6 m per pixel (mpp), providing ≈99% coverage with good‐quality images. Reconstruction of MRO's orbit and camera pointing from ground tracking are offset from the Mars global coordinate system. This work focuses on correcting those data for the more than 50,000 images in the equatorial region of Mars, between ±30° latitude, which comprises 50% of Mars' surface area. Determining and making these corrections in a relative control (image‐to‐image) and absolute or full control (image‐to‐ground reference) greatly improves the utility of the image data. Based on this work, the 95th percentile of tie points were offset from the Mars coordinate system by ≈155 m, corresponding to ≈28 CTX pixels. Controlling the more than 50,000 images was accomplished through an efficient, automated approach with additional manual input and validation, described herein. The mosaic was generated with semi‐manual image order from these controlled data and is provided at both 6 mpp and 100 mpp. The mosaic is available to the community through NASA's Planetary Data System Imaging & Cartography Annex.
New Insight Into the Transition From a SAR Arc to STEVE
Authors: Gillies D. M. , Liang J. , Gallardo‐Lacourt B. , Donovan E. 
Published: March 2023

AbstractIn this study, we present an analysis of the spectral transition of a Stable Auroral Red (SAR) arc to Strong Thermal Emission Velocity Enhancement (STEVE) emission observed by the Transition Region Explorer (TREx) Spectrograph on the night of 10 April 2022, recorded overhead in Lucky Lake, Saskatchewan. On this night, we see an unusually bright (∼2 kR) SAR arc with enhanced ionospheric flow channels in the conjugate southern hemisphere. Over a short time, on the order of minutes, we observe the spectra change from the typical SAR arc pure redline (630 and 636 nm) emission to the air glow continuum, a broadband enhancement across all wavelengths, characteristic of STEVE. We propose the presence of threshold conditions required for the SAR arc to evolve into STEVE. In addition, we present parameters such as transition times, luminosities, and arc motion to be applied to ionospheric models.
Spatiotemporal Drought Variation in Midlatitude East Asia Over the Past Half Millennium
Authors: Deng Yang , Gao Linlin , Gou Xiaohua 
Published: March 2023

AbstractDrought is a recurring challenge, especially in the arid and semi‐arid regions. Therefore, understanding its spatial and temporal variation is important for pre‐disaster planning and sustainable water resource management during drought. However, the sparse and short length of the instrumental records in midlatitude East Asia hampered the full understanding of drought variation, especially at multidecadal and longer timescales. Here, we compiled a tree‐ring network of 364 chronologies in midlatitude East Asia and reconstructed the variation of the averaged May–August Standardized Precipitation Evapotranspiration Index at a spatial resolution of 0.5° × 0.5°, for the period 1501–2000 CE. The reconstruction captured the spatial and temporal variation of actual drought well and has a strong association with a drought atlas that was derived from historical documents. The study area has experienced an expansion of dry areas during the past decades; however, it is still within the natural variability of the past half millennium. According to drought variation during the instrumental period, the study area was divided into four subregions; however, running correlations showed that drought variation in some subregions was similar in past centuries, except in recent decades. This study provides new data for understanding the spatiotemporal variability of drought in midlatitude East Asia, and the vanished correlation between drought variation in some regions during the past decades indicates the complex forcing mechanism of regional drought variation.
Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine
Authors: Qiu Shaofu , Chen Zhao , Zhu Airu , Zeng Qiuhui , Liu Hongbo , Liu Xiaoqing , Ye Feng , Jin Yingkang , Wu Jie , Yang Chaojie , Wang Qi , Chen Fangli , Chen Lan , Tian Sai , Du Xinying , Hu Qingtao , Cheng Jinling , Chen Canjie , Li Fang , Sun Jing , Wang Yanqun , Zhao Jingxian , Zhao Jincun , Song Hongbin 
Published: March 2023

AbstractPersistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases displayed low levels of inflammatory and interferon response, weak antibody response, diminished circulating follicular helper T cells (cTfh), and inadequate specific CD4+ and CD8+ T-cell responses during infection, which is distinct from symptomatic infections and resembling impaired immune activation. Administration of a single dose of Ad5-nCoV vaccine to 10 of these PA cases elicited rapid and robust antibody responses as well as coordinated B-cell and cTfh responses, resulting in successful viral clearance. Vaccine-induced antibodies were able to neutralize various variants of concern and persisted for over 6 months, indicating long-term protection. Therefore, our study provides an insight into the immune status of PA infections and highlights vaccination as a potential treatment for prolonged SARS-CoV-2 infections.
Delayed diagnosis resulting in increased disease burden in multiple myeloma: the legacy of the COVID-19 pandemic
Authors: Carmichael Jonathan , Seymour Frances , McIlroy Graham , Tayabali Sarrah , Amerikanou Rosie , Feyler Sylvia , Popat Rakesh , Pratt Guy , Parrish Christopher , Ashcroft A. John , Jackson Graham H. , Cook Gordon 
Published: March 2023

AbstractThe COVID-19 pandemic has had global healthcare impacts, including high mortality from SARS-CoV-2 infection in cancer patients; individuals with multiple myeloma (MM) are especially susceptible to poor outcomes. However, even for MM patients who avoided severe infection, the ramifications of the pandemic have been considerable. The consequences of necessary socio-geographical behavior adaptation, including prolonged shielding and interruptions in delivery of non-pandemic medical services are yet to be fully understood. Using a real-world dataset of 323 consecutive newly diagnosed MM patients in England, we investigated the impact of the COVID-19 pandemic on routes to myeloma diagnosis, disease stage at presentation and relevant clinical outcomes. We demonstrate increasing MM presentations via emergency services and increased rates of bony and extra-medullary disease. Differences were seen in choice of induction therapy and the proportion of eligible patients undertaking autologous stem cell transplantation. Whilst survival was statistically inferior for emergency presentations, significant survival differences have yet to be demonstrated for the entire cohort diagnosed during the pandemic, making extended follow-up critical in this group. This dataset highlights wide-ranging issues facing MM patients consequent of the COVID-19 pandemic, with full impacts for clinicians and policy-makers yet to be elucidated.
Understanding opposing predictions of Prochlorococcus in a changing climate
Authors: Bian Vincent , Cai Merrick , Follett Christopher L. 
Published: March 2023

AbstractStatistically derived species distribution models (SDMs) are increasingly used to predict ecological changes on a warming planet. ForProchlorococcus, the most abundant phytoplankton, an established statistical prediction conflicts with dynamical models as they predict large, opposite, changes in abundance. We probe the SDM at various spatial-temporal scales, showing that light and temperature fail to explain both temporal fluctuations and sharp spatial transitions. Strong correlations between changes in temperature and population emerge only at very large spatial scales, as transects pass through transitions between regions of high and low abundance. Furthermore, a two-state model based on a temperature threshold matches the original SDM in the surface ocean. We conclude that the original SDM has little power to predict changes whenProchlorococcusis already abundant, which resolves the conflict with dynamical models. Our conclusion suggests that SDMs should prove efficacy across multiple spatial-temporal scales before being trusted in a changing ocean.
Stereoselective C–O silylation and stannylation of alkenyl acetates
Authors: Hu Ying , Peng Jiali , Hu Binjing , Wang Jixin , Jing Jing , Lin Jie , Liu Xingchen , Qi Xiaotian , Li Jie 
Published: March 2023

AbstractFacile formation of carbon-heteroatom bonds is a long-standing objective in synthetic organic chemistry. However, direct cross-coupling with readily accessible alkenyl acetates via inert C‒O bond-cleavage for the carbon-heteroatom bond construction remains challenging. Here we report a practical preparation of stereoselective tri- and tetrasubstituted alkenyl silanes and stannanes by performing cobalt-catalyzed C‒O silylation and stannylation of alkenyl acetates using silylzinc pivalate and stannylzinc chloride as the nucleophiles. This protocol features a complete control of chemoselectivity, stereoselectivity, as well as excellent functional group compatibility. The resulting alkenyl silanes and stannanes show high reactivities in arylation and alkenylation by Hiyama and Stille reactions. The synthetic utility is further illustrated by the facile late-stage modifications of natural products and drug-like molecules. Mechanistic studies suggest that the reaction might involve a chelation-assisted oxidative insertion of cobalt species to C‒O bond. We anticipate that our findings should prove instrumental for potential applications of this technology to organic syntheses and drug discoveries in medicinal chemistry.
High interspecific competitiveness of the invasive plant Xanthium italicum Moretti severely reduces the yield and quality of Carthamus tinctorius L.
Authors: Ma Xia , Hou Mingcai , Ma Miao 
Published: March 2023

AbstractSafflower is an annual herb of Compositae, which has great economic value. To explore the impact of invasive weedXanthium italicumMoretti on the economic crop safflower, field experiments were conducted, the growth-related characters and the relative intensity of competition between the two species was explored. The results showed that under monoculture conditions, the stem height, crown width, stem diameter and the biomass ofX. italicumroot, stem and leaves were 1.14, 1.96, 1.82, 4.42, 4.21 and 3.99 times as high as those of safflower, respectively. When the two species coexisted, the growth related characters ofX. italicumwere further significantly improved, while the growth related characters of safflower were significantly decreased. When coexisted withX. italicum, the corolla biomass, hydroxysafflor yellow A content of corolla, seed yields, 100-seed weight, and seed oil content of safflower in the interplanted treatment 90.04%, 33.11%, 63.89%, 40.58%, and 25.61% lower than those in the monocultured treatment, respectively. Relative yield (RY) and Competitive balance index (CB) ofX. italicumand safflower showed that the interspecific competitiveness ofX. italicumwas significantly higher than that of safflower. Under the competitive inhibition ofX. italicum,not only the vegetative growth, but also the reproductive growth, yield, and quality of the economic organs of safflower were significantly negatively impacted. Together, our findings provide important scientific basis for evaluating the invasion risks and consequences of safflower’s cropland ecosystem byX. italicum.
αSiC - βSiC - graphene composites
Authors: Razmjoo Ali , Baharvandi Hamid Reza , Ehsani Nasser 
Published: March 2023

AbstractIn this study, the mechanical properties of the pressureless sintered samples of α-SiC based composite containing 0–3 wt.% graphene and 0–15 wt.% nano β-SiC were investigated. Simultaneous usage of nano β-SiC and graphene and transformation of β-SiC (3C) to α-SiC (6H/4H) resulted in elongation of secondary α-SiC grains, which significantly improved the mechanical properties (e.g. fracture toughness) of SiC ceramics. According to the results, the highest Relative density of 99.04%, Young’s modulus of 537.76 GPa and fracture toughness of 5.73 MPa × m1/2 were obtained in the sample containing 5 wt.% nano β-SiC and 1 wt.% graphene (5B1G). In addition, two methods of measuring bending strength including three-point bending tests and biaxial tests (piston-on-three-ball) were compared. Strip-shaped specimens were prepared for three-point bending test and disc-shaped specimens were prepared for biaxial bending test. Each bending test was evaluated using a universal testing machine. The results showed that the biaxial bending strength is less than the three-point bending strength. Also, the maximum three-point bending strength of 582.01 MPa and biaxial bending of 441.56 MPa were obtained in 5 wt.% Nano β-SiC and 1 wt.% Graphene samples (5B1G). Studies have shown that in addition to the many advantages of using the biaxial bending method, the results have a very similar trend to the three-point bending strength. Also, the most-increased hardnesses of 28.03 GPa and 29.97 GPa were seen in the sample containing 5 wt.% nano β-SiC (5B) with forces of 10 N and 1 N, respectively. One of the effective mechanisms in improving the fracture toughness of α-SiC ceramics is crack deflection/bridging. Also, the difference in thermal expansion of the α-SiC matrix and the reinforcements, leading to the creation of residual stresses between the matrix grains and the reinforcement, is effective in improving the mechanical properties (e.g. strength and fracture toughness).
Tunable growth of one-dimensional graphitic materials: graphene nanoribbons, carbon nanotubes, and nanoribbon/nanotube junctions
Authors: Lou Shuo , Lyu Bosai , Chen Jiajun , Qiu Lu , Ma Saiqun , Shen Peiyue , Zhang Zhichun , Xie Yufeng , Liang Qi , Watanabe Kenji , Taniguchi Takashi , Ding Feng , Shi Zhiwen 
Published: March 2023

AbstractGraphene nanoribbons (GNRs) and carbon nanotubes (CNTs), two representative one-dimensional (1D) graphitic materials, have attracted tremendous research interests due to their promising applications for future high-performance nanoelectronics. Although various methods have been developed for fabrication of GNRs or CNTs, a unified method allowing controllable synthesis of both of them, as well as their heterojunctions, which could largely benefit their nano-electronic applications, is still lacking. Here, we report on a generic growth of 1D carbon using nanoparticles catalyzed chemical vapor deposition (CVD) on atomically flat hexagonal boron nitride (h-BN) substrates. Relative ratio of the yielded GNRs and CNTs is able to be arbitrarily tuned by varying the growth temperature or feeding gas pressures. The tunability of the generic growth is quantitatively explained by a competing nucleation theory: nucleation into either GNRs or CNTs by the catalysts is determined by the free energy of their formation, which is controlled by the growth conditions. Under the guidance of the theory, we further realized growth of GNR/CNT intramolecular junctions through changing H2 partial pressure during a single growth process. Our study provides not only a universal and controllable method for growing 1D carbon nanostructures, but also a deep understanding of their growth mechanism, which would largely benefit future carbon-based electronics and optoelectronics.
Live-cell photoactivated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
Authors: Hou Yufeng , Laasmaa Martin , Li Jia , Shen Xin , Manfra Ornella , Nordén Einar S. , Le Christopher , Zhang Lili , Sjaastad Ivar , Jones Peter P. , Soeller Christian , Louch William E. 
Published: March 2023

AbstractCa2+ sparks constitute the fundamental units of Ca2+ release in cardiomyocytes. Here we investigate how ryanodine receptors (RyRs) collectively generate these events by employing a transgenic mouse with a photoactivated label on RyR2. This allowed correlative imaging of RyR localization, by super-resolution photoactivated localization microscopy, and Ca2+ sparks, by high-speed imaging. Two populations of Ca2+ sparks were observed: stationary events and ‘traveling’ events that spread between neighboring RyR clusters. Traveling sparks exhibited up to eight distinct releases, sourced from local or distal junctional sarcoplasmic reticulum. Quantitative analyses showed that sparks may be triggered by any number of RyRs within a cluster, and that acute β-adrenergic stimulation augments intracluster RyR recruitment to generate larger events. In contrast, RyR ‘dispersion’ during heart failure facilitates the generation of traveling sparks. Thus, RyRs cooperatively generate Ca2+ sparks in a complex, malleable fashion, and channel organization regulates the propensity for local propagation of Ca2+ release.