bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isopropyl alcohol inhalation versus 5-HT3 antagonists for treatment of nausea: a meta-analysis of randomised controlled trials
Authors: Kimber James S. , Kovoor Joshua G. , Glynatsis John M. , West Samuel J. , Mai Thi Thien Nhi , Jacobsen Jonathan Henry W. , Ovenden Christopher D. , Bacchi Stephen , Hewitt Joseph N. , Gupta Aashray K. , Edwards Suzanne , Taverner Fiona J. , Watson David I. 
Published: September 2023

Abstract
Purpose
Nausea is a common and unpleasant sensation for which current therapies such as serotonin (5-HT3) antagonists are often ineffective, while also conferring a risk of potential adverse events. Isopropyl alcohol (IPA) has been proposed as a treatment for nausea. We aimed to compare IPA with 5-HT3 antagonists for the treatment of nausea across all clinical settings.

Methods
MEDLINE, EMBASE, PubMed, CENTRAL and CINAHL were searched from inception to 17 July 2023 for randomised controlled trials (RCTs) comparing inhaled IPA and a 5-HT3 antagonist for treatment of nausea. Severity and duration of nausea, rescue antiemetic use, adverse events and patient satisfaction were the outcomes sought. Risk of bias (RoB) was assessed using Cochrane RoB 2. Random-effects model was used for meta-analysis. Combination of meta-analyses and narrative review was used to synthesise findings. The evidence was appraised using GRADE.

Results
From 1242 records, 4 RCTs were included with 382 participants. Participants receiving IPA had a significantly lower mean time to 50% reduction in nausea (MD − 20.06; 95% CI − 26.26, − 13.85). Nausea score reduction at 30 min was significantly greater in the IPA group (MD 21.47; 95% CI 15.47, 27.47). IPA led to significantly reduced requirement for rescue antiemetics (OR 0.60; 95% CI 0.37, 0.95; p = 0.03). IPA led to no significant difference in patient satisfaction when compared with a 5-HT3 antagonist. The overall GRADE assessment of evidence quality ranged from very low to low.

Conclusion
IPA may provide rapid, effective relief of nausea when compared with 5-HT3 antagonists.
Outcomes of Metaplastic Breast Cancer Versus Triple‐Negative Breast Cancer: A Propensity Score Matching Analysis
Authors: Tan YuPing , Yang Biao , Chen YuHong , Yan Xi 
Published: September 2023

AbstractPurposeThis study aims to compare the survival outcomes of metaplastic breast cancer (MPBC) with triple‐negative breast cancer (TNBC) and identify prognostic factors that influence the survival outcomes of MPBC patients and TNBC patients.MethodsPatients with nonmetastatic MPBC or TNBC were reviewed from our database. Patients’ clinicopathologic and molecular features were analyzed with respect to outcomes, including disease‐free survival (DFS) and overall survival (OS). Propensity score matching (PSM) with a one‐to‐three matching between MPBC patients and TNBC patients was performed.ResultsA total of 857 female patients (76 MPBC patients and 781 TNBC patients) were included in this study. A subgroup of triple‐negative MPBC (n  =  60) was matched with TNBC (n  =  180) cases based on patient characteristics and treatments. Kaplan–Meier analysis indicated that the MPBC group was associated with worse OS and DFS before (P  =  0.0046 both) and after (P  =  0.011 and P  =  0.0046, respectively) PSM. Multivariable analysis revealed that a higher T stage (T > 2) (P  =  0.032) and higher lymph node stage (N3 vs. N0‐2, P  =  0.012) were associated with worse OS after PSM. For DFS, the MPBC group (P  =  0.012), higher T stage (T > 2) (P  =  0.032), and higher lymph node stage (N3 vs. N0‐2, P  =  0.045) were associated with worse DFS. Among the 76 MPBC patients, a higher T stage and mesenchymal differentiation were associated with worse OS (pT1/2 vs. pT3/4 and mesenchymal differentiation vs. other subtypes, P  =  0.007 and P  =  0.011, respectively).ConclusionsCompared with TNBC, MPBC was associated with worse OS and DFS. Mesenchymal differentiation has a worse DFS than other subtypes of MPBC.
To shield or not to shield: shielding may have unintended effects on patient dose in CT
Authors: Larjava Heli Riitta Sinikka , Eneh Chibuzor T. M. , Niiniviita Hannele M. 
Published: September 2023

Abstract
Objectives
The aim of the patient out-of-plane shield is to reduce the patient radiation dose. Its effect on tube current modulation was evaluated with the out-of-plane shield visible in the localizer but absent in the scan range in chest CT with different CT scanners.

Methods
An anthropomorphic phantom was scanned with six different CT scanners from three different vendors. The chest was first scanned without any shielding, and then with the out-of-plane shield within the localizer but outside the imaged volume. All pitch values of each scanner were used. The tube current values with and without the out-of-plane shield were collected and used to evaluate the effect of overscanning and tube current modulation (TCM) on patient radiation dose.

Results
The highest increase in cumulative mA was 217%, when the pitch was 1.531. The tube current value increased already 8.9 cm before the end of the scanned anatomy and the difference between the tube current of the last slices (with and without the out-of-plane shield in the localizer) was 976%.

Conclusion
Applying an out-of-plane shield outside the scanned volume but visible in the localizer images may increase the patient dose considerably if the scanner’s TCM function is based only on localizer images.

Clinical relevance statement
The use of an out-of-plane shield in CT may strongly increase the tube current modulation and thus provide the patient with a higher radiation dose.

Key Points
• Applying an out-of-plane shield outside the scanned volume but visible in the localizer images may increase patient radiation dose considerably.
• The effect is visible with scanners that use solely localizer-based tube current modulation.
• Features like overscanning may be difficult for the user to notice when planning the scanning, and yet they may affect tube current modulation and through it to patient dose.
Bone turnover in lactating and nonlactating women
Authors: Nerius Lena , Vogel Mandy , Ceglarek Uta , Kiess Wieland , Biemann Ronald , Stepan Holger , Kratzsch Jürgen 
Published: September 2023

Abstract
Purpose
During lactation, bone turnover increases, reflecting the mobilization of Calcium from maternal skeletal stores and resulting in bone loss. However, mechanisms are not yet fully understood, and previous studies have been comparatively small. We aim to assess bone metabolism during lactation by comparing bone-metabolism-related-parameters between large cohorts of lactating and nonlactating women.

Methods
In a retrospective cohort study, we recruited 779 postpartum women and 742 healthy, nonpregnant, nonlactating controls. Postpartum women were examined 3 and 6 months after delivery and retrospectively assigned to either the exclusively breastfeeding (exc-bf) group if they had exclusively breastfed or the nonexclusively breastfeeding (nonexc-bf) group if they had not exclusively breastfed up to the respective visit. Serum levels of PTH, Estradiol, total Calcium, Phosphate, and bone turnover markers (ßCTX, P1NP, Osteocalcin) were compared between the groups.

Results
Bone turnover markers were significantly increased in exc-bf and nonexc-bf women compared with the controls (all ps < .001). ßCTX was approximately twice as high in exc-bf women than in the controls. PTH levels were marginally higher in exc-bf (p < .001) and nonexc-bf women (p = .003) compared with the controls (6 months). Estradiol was suppressed in exc-bf women compared with the controls (p < .001, 3 months).

Conclusion
Exc-bf and even nonexc-bf states are characterized by an increase in bone formation and resorption markers. The PTH data distribution of exc-bf, nonexc-bf, and control groups in the underpart of the reference range suggest that lactational bone loss is relatively independent of PTH.
Ochratoxin A biodegradation by Agaricus campestris and statistical optimization of cultural variables
Authors: Söylemez Tuncay , Yamaç Mustafa , Eninanç Ayşe Betül , Yıldız Zeki 
Published: September 2023

AbstractThe goal of this study is to identify the optimum conditions for ochratoxin A (OTA) biodegradation by the supernatant of Agaricus campestris strain. The Plackett–Burman and Box–Behnken methods were used to determine optimum OTA degradation conditions of Agaricus campestris under various incubation conditions. The Plackett–Burman method was planned through 16 varied experiments with 15 variants. The three most potent variants, sucrose, yeast extract and wheat bran, were selected using the Box–Behnken methodology. Ochratoxin A biodegradation ratio of 46.67% has been specified in only 1 h under ideal growing conditions. This is the first report on the optimization of OTA biodegradation by Agaricus campestris. When compared to previously published articles, it can be asserted that Agaricus campestris has promise based on its OTA biodegradation ratio in only 1 h of reaction time.
Effects of a homework implementation method (MITCA) on school engagement
Authors: Vieites T. , Díaz-Freire F. M. , Rodríguez S. , Rodríguez-Llorente C. , Valle A. 
Published: September 2023

AbstractMITCA (homework implementation method) was born with the purpose of turning homework into an educational resource capable of improving the self-regulation of learning and the school engagement of students. In this article, following the current theoretical framework, we evaluate the impact of the MITCA method on school engagement in students in the 5th and 6th years of Primary Education. While the control group of students who did not participate in the 12 weeks of MITCA (N = 431; 61% of 5th grade) worsened significantly in emotional, behavioral, and cognitive engagement, these pre-post differences do not reach significance for the group that has participated in MITCA, even observing a tendency to improve. After the intervention, the students who participated in MITCA (N = 533; 50.6% of 5th grade) reported greater emotional and behavioral engagement than the students in the control group. MITCA students showed positive emotions, were happier in school and were more interested in the classroom, paid more attention in class, and were more attentive to school rules. The conditions of the tasks’ prescription proposed by MITCA would not only restrain the lack of engagement but would also improve students’ emotional and behavioral engagement in school found in the last years of Primary Education. In the light of the results, a series of educational strategies related to the characteristics of these tasks, such as the frequency of prescription and the type of correction are proposed.
Biomechanical characterization of tissue types in murine dissecting aneurysms based on histology and 4D ultrasound-derived strain
Authors: Hegner Achim , Cebull Hannah L. , Gámez Antonio J. , Blase Christopher , Goergen Craig J. , Wittek Andreas 
Published: September 2023

AbstractAbdominal aortic aneurysm disease is the local enlargement of the aorta, typically in the infrarenal section, causing up to 200,000 deaths/year. In vivo information to characterize the individual elastic properties of the aneurysm wall in terms of rupture risk is lacking. We used a method that combines 4D ultrasound and direct deformation estimation to compute in vivo 3D Green-Lagrange strain in murine angiotensin II-induced dissecting aortic aneurysms, a commonly used mouse model. After euthanasia, histological staining of cross-sectional sections along the aorta was performed in areas where in vivo strains had previously been measured. The histological sections were segmented into intact and fragmented elastin, thrombus with and without red blood cells, and outer vessel wall including the adventitia. Meshes were then created from the individual contours based on the histological segmentations. The isolated contours of the outer wall and lumen from both imaging modalities were registered individually using a coherent point drift algorithm. 2D finite element models were generated from the meshes, and the displacements from the registration were used as displacement boundaries of the lumen and wall contours. Based on the resulting deformed contours, the strains recorded were grouped according to segmented tissue regions. Strains were highest in areas containing intact elastin without thrombus attachment. Strains in areas with intact elastin and thrombus attachment, as well as areas with disrupted elastin, were significantly lower. Strains in thrombus regions with red blood cells were significantly higher compared to thrombus regions without. We then compared this analysis to statistical distribution indices and found that the results of each aligned, elucidating the relationship between vessel strain and structural changes. This work demonstrates the possibility of advancing in vivo assessments to a microstructural level ultimately improving patient outcomes.
Triggers affecting crayfish burrowing behaviour
Authors: Peeters Edwin T. H. M. , de Vries Robin , Elzinga Jesper , Ludányi Mercédesz , van Himbeeck Robbert , Roessink Ivo 
Published: September 2023

AbstractSurface water inhabiting crayfish are well-known for the impact on their surroundings. This impact has been related to loss of biodiversity and deteriorating water quality for invasive crayfish. Crayfish dig burrows for various reasons like lack of natural shelters, avoiding an upcoming drought, or high crayfish density and this may lead to increased sediment transport and accelerated bank instability. All crayfish are considered to have burrowing capability, but not all species have been observed burrowing. Studies comparing this behaviour among different species in standardized ways are scarce. Crayfish burrowing was investigated under standardized laboratory conditions to reveal differences among species and their sex. All studied species occur in the Netherlands and were the native Astacus astacus (Linnaeus, 1758), the Eurasian Pontastacus leptodactylus (Eschscholtz, 1823) and the invasive North American Faxonius virilis (Hagen, 1870), F. limosus (Rafinesque 1817), Pacifastacus leniusculus (Dana, 1852), Procambarus acutus (Girard 1852), and P. clarkii (Girard, 1852). As burrowing triggers were evaluated presence of shelter, increased light intensity, increased water temperature, and increased crayfish density. Results showed species-specific and sometimes sex-specific differences in burrowing behaviour among crayfish. The response to burrowing triggers was also species-specific and no two species reacted identical to all triggers. Absence of shelter was a strong driver to burrow for A. astacus, F. limosus and F. virilis, while increased light intensity triggered burrowing behaviour in P. leptodactylus, P. acutus and P. clarkii and lowered activity of F. limosus. Burrowing behaviour of P. clarkii was mostly influenced by increased water temperature. Significant differences between females and males were observed for P. leptodactylus, P. leniusculus and P. acutus in the shelter, increased density and increased water temperature treatment, respectively. Understanding the triggers that invoke burrowing may help managing populations of these invasive species.
Dose-related responses of broiler chickens to black velvet tamarind (Dialium guineense) stem bark supplementation: carcass characteristics, organ weight and intestinal biometry
Authors: Ogbuewu Ifeanyichukwu P. , Mbajiorgu Christian A. 
Published: September 2023

AbstractCarcass characteristics, organ weights, and intestinal biometry of broiler chickens fed diets supplemented with black velvet tamarind (Dialium guineense) stem bark (BSB) were assessed. Two hundred, day-old Ross 308 broilers were divided into 4 groups of 50 chickens, and each group replicated five times. Each group were assigned to one experimental diet in a completely randomised design designated T0 (0), T1 (0.5), T2 (1.0) and T3 (1.5 g BSB/kg feed). Data obtained on carcass characteristics, organ weights, and intestinal biometry were analysed statistically. Results showed that BSB was low in crude protein (6.42%) and high in crude fibre (30.65%) and ash (9.35%). Broiler chickens fed diet T1 had significantly higher (P < 0.05) breast and drumstick weights than those offered the other 3 diets. There were significant differences (P < 0.05) in the abdominal fat pad, liver, proventriculus, gizzard weight, and intestinal biometry of broiler chickens in all the groups. Results also showed that dietary BSB supplementation level had a quadratic effect (P < 0.05) on breast, drumstick, liver, proventriculus weight, abdominal fat pad, and intestinal biometry of broiler chickens. In contrast, dietary BSB supplementation levels had linear effect (P < 0.05) on gizzard weight. It can be concluded that BSB is rich in ash and fibre, and is suitable as a feed additive in broiler chicken diets at a level not beyond 0.5 g/kg feed for best organ weight, carcass yield, intestinal biometry. Thus, there is potential to utilize BSB for improved productivity of broiler chickens.
Prominent Themes and Blind Spots in Diversity and Inclusion Literature: A Bibliometric Analysis
Authors: van Bommel H. M. , Hubers F. , Maas K. E. H. 
Published: September 2023

AbstractThis study aims to examine the development of diversity and inclusion (D&I) literature and identify its prominent themes and blind spots. The research was conducted using bibliometric analysis on the Web of Science database and included 2510 publications. Results showed that the development of D&I literature had increased exponentially since the 1960s, mainly due to different political and societal events. The geographic development showed that research was primarily conducted in developed countries where quotas and other legislation are implemented. The thematic development revealed a stable but narrow focus on diversity management, board diversity, and team diversity, with little attention to inclusion. The keyword analysis strongly emphasized surface-level diversity, such as gender, race, and cultural diversity, while deep-level diversity received less attention. This study concludes that previous D&I literature has mainly focused on the financial effects of D&I and neglected other elements, such as the effects on social performance, its ethical implications, and the relationship between diversity and inclusion. The study recommends future research to expand the interpretation of diversity, examine the relationship between diversity and inclusion, and explore the effects of diversity on non-financial outcomes such as social performance and ethics. This study provides a valuable contribution to the field of business ethics by highlighting the blind spots in D&I literature and encouraging future research to consider the ethical implications of diversity in the workplace.
Assessing Household’s Municipal Waste Segregation Intentions in Metropolitan Cities of Pakistan: A Structural Equation Modeling Approach
Authors: Akmal Tanzila , Jamil Faisal , Raza Muhammad Haseeb , Magazzino Cosimo , Hussain Babar 
Published: September 2023

AbstractThere is a growing concern about inappropriate waste disposal and its negative impact on human health and the environment. The objective of this study is to understand household waste segregation intention considering psychological, institutional, and situational factors simultaneously. Insights into the motivations of household waste segregation drivers may assist in a better knowledge of how to pursue the most efficient and effective initiatives. For this purpose, data from a representative sample comprising 849 households is obtained from the twin cities of Islamabad and Rawalpindi (Pakistan). The empirical analysis employs a Structural Equation Modeling (SEM) approach, showing that policy instruments have significant direct and indirect impacts on households’ segregation intentions. The results highlight that government policy instruments strengthen personal and perceived norms for waste segregation intentions, resulting in an external intervention that would encourage intrinsic motivation. Therefore, policy actions become the main entry point for initiating waste segregation behavior. Public policy must continue to emphasize waste segregation since it may help resource recovery. This is imperative because the environment is a shared resource, and its conservation increases social welfare.
Hungarian population norms for the 15D generic preference-accompanied health status measure
Authors: Nikl Anna , Janssen Mathieu F. , Brodszky Valentin , Rencz Fanni 
Published: September 2023

Abstract
Objectives
15D is a generic preference-accompanied health status measure covering a wide range of health areas, including sensory functions. The aim of this study was to establish population norms for the 15D instrument in Hungary.

Methods
2000 members of the Hungarian adult general population participated in an online cross-sectional survey in August 2021. The sample was broadly representative in terms of gender, age groups, highest level of education, geographical region, and settlement type. Index values were derived using the Norwegian 15D value set. In addition to providing population norms, mean index values were computed for 32 physical and 24 mental health condition groups.

Results
Most respondents (78.7%) reported problems in at least one 15D domain. The most problems were reported with sleeping (50.7%), followed by vitality (49.2%), distress (43.6%), discomfort and symptoms (31.2%), depression (31.1%), sexual activities (29.6%), breathing (28.1%), and vision (27.8%). The mean 15D index value was 0.810. With advancing age categories, the 15D index values showed an inverse U-shaped curve. Generally, mean index values in respondents with mental health conditions were lower [range 0.299 (post-traumatic stress disorder) to 0.757 (smoking addiction)] than those of respondents with physical conditions [range 0.557 (liver cirrhosis) to 0.764 (allergies)].

Conclusions
This study provided 15D population norms of the Hungarian general population; furthermore, this is the first study to provide population norms for the 15D in any country. The values established in this study can serve as benchmarks for evaluating efficacy outcomes in clinical trials, quantifying disease burden and identifying unmet needs.
A curated multivariate approach to study efficacy and optimisation of a prototype vaccine against teladorsagiasis in sheep
Authors: Palarea-Albaladejo Javier , McNeilly Tom N. , Nisbet Alasdair J. 
Published: September 2023

AbstractThis work discusses and demonstrates the novel use of multivariate analysis and data dimensionality reduction techniques to handle the variety and complexity of data generated in efficacy trials for the development of a prototype vaccine to protect sheep against theTeladorsagia circumcinctanematode. A curated collection of data dimension reduction and visualisation techniques, in conjunction with sensible statistical modelling and testing which explicitly model key features of the data, offers a synthetic view of the relationships between the multiple biological parameters measured. New biological insight is gained into the patterns and associations involving antigen-specific antibody levels, antibody avidity and parasitological parameters of efficacy that is not achievable by standard statistical practice in the field. This approach can therefore be used to guide vaccine refinement and simplification through identifying the most immunologically relevant antigens, and it can be analogously implemented for similar studies in other areas. To facilitate this, the associated data and computer codes written for the R open system for statistical computing are made freely available.