bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and feasibility study of ex vivo expanded allogeneic-NK cells infusion in patients with acute pneumonia caused by COVID-19
Authors: Ahmadvand Mohammad , Barough Mahdieh Shokrollahi , Hashemi Zahra Sadat , Sanati Hassan , Abbasvandi Fereshteh , Yunesian Masud , Majidzadeh-A Keivan , Makarem Jalil , Aghayan Hamid Reza , Abedini Atefeh , Ghavamzadeh Ardeshir , Forooshani Ramin Sarrami 
Published: August 2023

Abstract
Background
NK cells are the most active innate immune cells in antiviral immunity, which are impaired by SARS-COV2 infection. Infusion of allogeneic NK cells might be a complementary treatment to boost immune system function in COVID-19 patients. In this project, we focused on COVID-19 patients with low inspiratory capacity (LIC). This project aims to evaluate the feasibility and safety of allogeneic NK cell infusion as an intervention for respiratory viral disease.

Methods
A non-blind two arms pilot study was designed and conducted after signing the consent form. Ten matched patients, in terms of vital signs and clinical features, were enrolled in the control and intervention groups. Approximately 2 × 10^6 cells/kg of NK cells were prepared under GCP (good clinical practice) conditions for each patient in the intervention group. The control group was under the same conditions and drug regimen except for the treatment with the prepared cells. Then, infused intravenously during 20 min in the ICU ward of Masih Daneshvari Hospital. The clinical signs, serological parameters, and CTCAE (Common Terminology Criteria for Adverse Events) were recorded for safety evaluation and the feasibility of project management were evaluated via designed checklist based on CONSORT.

Results
There were no symptoms of anaphylaxis, hypersensitivity, significant changes in blood pressure, cardiovascular complications, and fever from injection time up to 48 h after cell infusion. The mean hospitalization period in the control and intervention groups was 10 and 8 days, respectively. The blood O2 saturation level was raised after cell infusion, and a significantly lower mean level of inflammatory enzymes was observed in the intervention group following discharge compared to the control group (p < 0.05). The inflammatory parameters differences at the discharge date in cell therapy group were highly negative.

Conclusion
Intravenous infusion of ex vivo-expanded allogeneic NK cells was safe and feasible. However, the efficacy of this approach to reducing the severity of disease in COVID-19 patients with LIC could not be determined.

Trial registration
Name of the registry: NKCTC. IRCT20200621047859N2. December 29, 2020. URL of trial registry record: https://www.irct.ir/trial/49382
Efficacy of polymethylmethacrylate membrane hemodiafilter Filtryzer® PMF™-21A in improving pruritus in hemodialysis patients: a prospective interventional study
Authors: Takahashi Naoko , Mano Jun , Uchida Kenta , Yoshizawa Taku , Kumagai Junko , Kawanishi Hideki , Tsuchiya Shinichiro , Moriishi Misaki , Masaki Takao 
Published: August 2023

Abstract
Background
Hemodialysis-associated pruritus (HAP) occurs in 60–80% of hemodialysis patients. This significant complication not only decreases quality of life through sleep disturbance and depression, but also leads to poor survival outcomes. The polymethylmethacrylate (PMMA) membrane was the first synthetic polymer membrane for the hollow-fiber artificial kidney created in 1977. PMMA membrane dialyzers have been reported to be effective for improving various complaints, including pruritus, and nutritional status. In Japan, a PMMA membrane hemodiafilter Filtryzer® PMF™-A (PMF-A) was launched in November 2021 and subsequently became available for online hemodiafiltration (OHDF). This study aimed to determine whether PMF-A effectively improves pruritus in hemodialysis patients.

Methods
Participants were 20 patients (median age 74.5 years) on predilution OHDF (pre-OHDF) or postdilution OHDF (post-OHDF) using an Asymmetric Triacetate Membrane® hemodiafilter (FIX-210E eco or FIX-210S eco), who were experiencing pruritus of “very mild” or higher severity based on the Shiratori severity score either during the daytime or nighttime. After switching to post-OHDF with PMF-21A (substitution flow rate: 10 L/session), the substitution flow rate was gradually increased according to results of pruritus evaluation every 2 weeks over 3 months. The primary endpoint was the severity of pruritus evaluated using visual analogue scale (VAS) and the Shiratori severity score. Secondary endpoints included white blood cell count (WBC), hemoglobin level (Hb), platelet count (Plt), serum albumin level (Alb), high-sensitivity C-reactive protein (hsCRP), IL-6, dry weight (DW), and solute removal performance.

Results
The median VAS score was significantly decreased 2 weeks after switching compared with baseline (44 mm) and remained significantly decreased at Week 12 (22 mm; p < 0.01). From baseline to Week 12, 16 patients (80%) showed improvement in VAS score. The percentage of patients with mild to moderate daytime pruritus according to the Shiratori severity score decreased significantly from 80.0% to 45.0% (p < 0.05), whereas no significant change was observed for nighttime pruritus (p = 0.267). Pre-dialysis serum β2-MG levels were significantly higher at Week 12 compared with baseline. No significant changes were observed in WBC, Hb, Plt, serum Alb, hsCRP, IL-6, or DW.

Conclusions
OHDF with PMF-21A may be more effective in improving HAP.
Unclassified bronchopulmonary foregut malformation in a 2-year-old girl
Authors: Kanai Risa , Fukumoto Koji , Miyake Hiromu , Kawasaki Tatsuya , Okuyama Katsumi , Iwafuchi Hideto , Koyama Masashi 
Published: August 2023

Abstract
Background
Bronchopulmonary foregut malformation (BPFM) is a rare congenital anomaly characterized by a fistula between an isolated portion of respiratory tissue and the esophagus or stomach. Srikanth et al. reported that BPFMs can be categorized into four groups, and that an unclassified BPFM is extremely rare. Herein, we present an unclassified BPFM group III and IV subtype in a 2-year-old girl.

Case presentation
At a gestational age of 36 weeks, a 1535-g female neonate was born as one of the dichorionic diamniotic twins. She had vertebral abnormality, anovestibular fistula, pulmonary artery sling, small right lung, mediastinal shift with dextrocardia, tracheal stenosis, and radial hemimelia. After birth, she was diagnosed with VACTERL association. She exhibited consolidation of the right upper lobe (RUL) in the neonatal period; however, she had no respiratory symptoms and was kept under observation in an outpatient visit. At 24 months, she was urgently admitted with acute pneumonia, and the upper gastrointestinal series revealed the right upper bronchus arising from the lower esophagus. Therefore, she underwent RUL resection. Intraoperatively, the right lung had no lobulations. RUL was ventilated by the esophageal bronchus (BPFM group III); however, the S6 lesion was ventilated by both the normal bronchial system and esophageal bronchus (close to BPFM group IV). The S6 lesion did not satisfy the definition of group IV as it did not have systemic blood supply. Hence, we decided to preserve the S6 lesion to save lung capacity as much as possible. The esophageal bronchus was transected using a 5-mm stapler. Due to lobulation failure, RUL was resected using an electric scalpel and 5-mm staplers along with the demarcation line by ventilation from the normal bronchus. The postoperative course was uneventful, and the patient could regain oral function without pneumonia or respiratory distress.

Conclusions
For neonates with repeated consolidation and pneumonia, BPFM must be considered as one of the differential diagnoses. Regarding BPFM treatment, early recognition and imaging are necessary. To determine the resection area of the lung, it is crucial to consider the segment of ventilation from the normal bronchi.
ΤΙΤΙΚΑ ΔΗΜΗΤΡΟΥΛΙΑ, Τα ηλεκτρονικά σώματα κειμένων και η ανάλυσή τους. Ερευνητικές προοπτικές για τη μελέτη της λογοτεχνίας
Authors: Δημητρούλια Τιτίκα 
Published: August 2023

Les corpus numériques et leur analyse. Perspectives interprétatives dans l’étude de la littérature
Cet article se propose de donner un aperçu de l’utilisation des corpus numériques dans les études littéraires et de l’apport de leur analyse à l’aide des outils numériques à la recherche. Il vise à présenter brièvement, dans une perspective herméneutique, la textométrie, comme cette méthode s’appelle dans le domaine francophone où elle a une longue histoire, de discuter les problèmes relatifs aux outils de traitement de la langue grecque, et de donner quelques exemples de son application à l’étude de la littérature néohellénique. Son objectif serait d’encourager l’explora- tion de la méthode par les chercheurs grecs, dans le cadre la transformation numérique de la recherche des sciences humaines et sociales.
What makes an excellent labour ward co-ordinator? Insights from the multidisciplinary team
Authors: Bunford Debra , Collier Lesley , Greaves Peta Jane 
Published: August 2023

Background/Aims Poor multidisciplinary teamwork on labour wards may lead to adverse consequences for women and babies. The labour ward co-ordinator is a central role in the multidisciplinary team; however, there has been little research into explore the skills and attributes necessary for this role. This study aimed to explore the labour ward co-ordinator's skills and attributes and their impact on multidisciplinary team working. Methods Constructive grounded theory was used to explore the perceptions of 21 labour ward multidisciplinary team members recruited using theoretical sampling from a maternity unit in northern England. Results Labour ward co-ordinators play significant roles in ward organisation, team situational awareness and a well-functioning multidisciplinary team. Co-ordinators had situational awareness through a ‘helicopter view’ of the ward, supported decision making and were approachable. Excellent labour ward co-ordinators used situational awareness to pre-empt emergencies and forward plan. Conclusions The labour ward co-ordinator role requires a different skillset to that of midwives delivering one-to-one care in labour. To develop midwives into the co-ordinator role, attention to continuing professional development is essential. Recruitment of consultant midwives dedicated to supporting midwives delivering care to women in labour should be considered.
Influence of temperature and humidity on scattering characteristics of aerosol particles in the terahertz band
Authors: Gao Xuan , An Yingzhao , Han Yiping , Wang Jiajie , Cui Zhiwei , Briard Paul 
Published: August 2023

The terahertz band is considered to be the next breakthrough point to revolutionize communication technology, attributed to its rich spectrum resources. The study of terahertz atmospheric transmission characteristics is important in guiding the terahertz communication window selection process. In this report, based on the equivalent medium theory, the scattering characteristics of terahertz Gaussian beams by moist media are discussed. Numerical results show that the extinction coefficient of particles is mainly affected by the humidity, and the scattering efficiency is affected by both temperature and humidity. When the temperature is over 273 K and the humidity is 0.5, the extinction efficiency shows a trend of increasing initially and decreasing afterwards. Hence, the appropriate temperature is beneficial to minimizing the attenuation coefficient.
Analysis of altered level of blood-based biomarkers in prognosis of COVID-19 patients
Authors: Shrestha Mahendra Raj , Basnet Ajaya , Tamang Basanta , Khadka Sudip , Maharjan Rajendra , Maharjan Rupak , Chand Arun Bahadur , Thapa Suresh , Rai Shiba Kumar 
Published: August 2023

Introduction
Immune and inflammatory responses developed by the patients with Coronavirus Disease 2019 (COVID-19) during rapid disease progression result in an altered level of biomarkers. Therefore, this study aimed to analyze levels of blood-based biomarkers that are significantly altered in patients with COVID–19.

Methods
A cross-sectional study was conducted among COVID-19 diagnosed patients admitted to the tertiary care hospital. Several biomarkers–biochemical, hematological, inflammatory, cardiac, and coagulatory–were analyzed and subsequently tested for statistical significance at P<0.01 by using SPSS version 17.0.

Results
A total of 1,780 samples were analyzed from 1,232 COVID-19 patients (median age 45 years [IQR 33–57]; 788 [63.96%] male). The COVID-19 patients had significantly (99% Confidence Interval, P<0.01) elevated levels of glucose, urea, alanine transaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), ferritin, D-Dimer, and creatinine phosphokinase-MB (CPK-MB) compared to the control group. However, the levels of total protein, albumin, and platelets were significantly (P<0.01) lowered in COVID-19 patients compared to the control group. The elevated levels of glucose, urea, WBC, CRP, D-Dimer, and LDH were significantly (P<0.01) associated with in-hospital mortality in COVID-19 patients.

Conclusions
Assessing and monitoring the elevated levels of glucose, urea, ALT, AST, ALP, WBC, CRP, PCT, IL-6, ferritin, LDH, D-Dimer, and CPK-MB and the lowered levels of total protein, albumin, and platelet could provide a basis for evaluation of improved prognosis and effective treatment in patients with COVID-19.
The association between COVID-19 preventive behaviors and mental health conditions
Authors: Wachira Elizabeth , Chavan Bhakti , Nganga-Good Carolyn , Kingori Caroline 
Published: August 2023

Background
An unintended consequence of COVID-19 quarantine preventive measures, is the increased prevalence of anxiety and depression. The purpose of this study was to examine the association between COVID-19 preventive behaviors and mental health conditions.

Methods
A cross-sectional study was conducted using secondary data collected weekly from US adults aged 18 and older nationwide as part of the COVID-19 Household Impact Survey (CIS) from the University of Chicago. Logistic regression examined associations between COVID-19 preventive behaviors (wearing a face mask, washing or sanitizing hands, and keeping six-feet distance from those outside their household), mental health conditions (self-reporting feeling nervous, anxious, or on edge, feeling lonely, and feeling hopeless about the future and a history of a mental health condition) and demographic factors.

Results
Majority of study participants were under 60 years (62.2%), female (55.8%), and non-Hispanic White (72.2%). Overall, participants more likely to have followed all three COVID-19 measures were those who reported high psychological distress compared to those with low distress for feeling anxious (adj. OR 1.16, 95% CI: 1.06–1.28, p = 0.002), lonely (adj. OR 1.12, 95% CI: 1.02–1.23, p = 0.019) or hopeless (adj. OR 1.10, 95% CI: 1.00–1.21, p = 0.043) for more than a day during the past 7 days.

Conclusion
Our findings highlight that individuals with mental health conditions reported more psychological distress. Specifically, feeling depressed, anxious, lonely, and hopeless were triggered and exacerbated as a result of the pandemic and may have long-term effects on general well-being and productivity. Therefore, our findings have important implications on the need to include mental health promotion as part of pandemic response efforts. This includes developing policies and allocating funding so as to ensure sustainable mental health interventions and support, public and provider education on the importance of screening for mental health issues.
Using gamma-band transcranial alternating current stimulation (tACS) to improve sleep quality and cognition in patients with mild neurocognitive disorders due to Alzheimer’s disease: A study protocol for a randomized controlled trial
Authors: Lu Hanna , Li Jing , Yang Natalie Shu , Lam Linda Chiu Wa , Ma Suk Ling , Wing Yun Kwok , Zhang Li 
Published: August 2023

Background
Sleep disturbances are highly prevalent in patients with age-related neurodegenerative diseases, which severely affect cognition and even lead to accumulated β-amyloid. Encouraging results from recent studies on transcranial direct current stimulation (tDCS) showed moderate positive effects on sleep quality in preclinical Alzheimer’s disease (AD). Compared to tDCS, transcranial alternating current stimulation (tACS) enables the entrainment of neuronal activity with optimized focality through injecting electric current with a specific frequency and has significant enhancement effects on slow wave activities.

Methods and design
This is a randomized, double-blind, sham-controlled clinical trial comparing 40 Hz tACS with tDCS in mild neurocognitive disorders due to AD with sleep disturbances. Magnetic resonance imaging (MRI) data is used to construct personalized realistic head model. Treatment outcomes, including sleep quality, cognitive performance and saliva Aβ levels will be conducted at baseline, 4th week, 8th week, 12th week and 24th week.

Conclusions
It is expected that the repeated gamma-band tACS will show significant improvements in sleep quality and cognitive functions compared to tDCS and sham tDCS. The findings will provide high-level evidence and guide further advanced studies in the field of neurodegenerative diseases and sleep medicine.

Trial registration
ClinicalTrials.gov Identifier: NCT05544201.
Uso da lei de newcomb-benford: uma contribuição à auditoria de conformidade contábil na Rede Federal de Educação Profissional e Tecnológica
Authors: Oliveira da Silva Jailson , Rodrigues Boente Diego 
Published: August 2023

Objetivo: Analisar o potencial da LNB de utilização como ferramenta de auditoria de conformidade contábil das despesas orçamentárias e patrimoniais da Rede Federal de Educação Profissional e Tecnológica (RFEPT).
Método: Foi realizado um estudo de caráter descritivo, com abordagem quantitativa, por meio dos testes z, qui-quadrado e MDA, utilizando-se de dados secundários das despesas orçamentárias e patrimoniais de 42 instituições que compõem a Rede Federal de Educação Profissional e Tecnológica. Os dados foram extraídos utilizando-se o sistema Tesouro Gerencial, sendo coletados dados do período de 2017 a 2020.
Resultados/Discussão: As hipóteses de que os dados orçamentários e patrimoniais das entidades da RFEPT selecionadas não apresentam discrepâncias com os parâmetros da LNB não foi confirmada para a maioria dos casos selecionados, conforme testes z, qui-quadrado e MDA, sendo possível observar distorções em alguns dígitos dos valores analisados, que podem estar associadas a erros, fraudes ou a características particulares das transações das entidades. Os resultados encontrados apontam para a possibilidade de utilização da LNB como uma importante técnica nos trabalhos de auditoria na RFEPT.
Contribuições: O estudo avança na discussão sobre o uso da LNB como ferramenta de auditoria de conformidade contábil ao apresentar resultados no cenário da Rede Federal de Educação Profissional e Tecnológica.
Exploring anticancer activity of the Indonesian guava leaf (Psidium guajavaL.) fraction on various human cancer cell lines in anin vitrocell-based approach
Authors: Prakoso Nurcahyo Iman , Nita Mila Tria 
Published: August 2023

AbstractBreast and cervical cancers are the leading cause of death in women, and chemotherapy with cytotoxins is the usual treatment. This study evaluated the cytotoxicity of guava leaf (Psidium guajavaL.) extracts as an alternative chemotherapeutic drug. Although many studies related to the cytotoxic effects of guava leaf (Psidium guajavaL.) on cancer cells have been reported, the effects of guava leaf fractions on human breast and cervical cancer cells (T47D, MCF-7, and HeLa) have never been evaluated. Herein, we researched candidate activities of ethanol, ethyl acetate, andn-extracts from guava leaf fractions and their effect on various human cancer cell lines (T47D, MCF-7, and HeLa cells). The cytotoxicity test was carried out using the microtetrazolium assay for all fractions. We confirmed and showed thein vitroantitumor activity of guava leaf (Psidium guajavaL.) fractions in human breast and cervical cancer cells. We found that the effectiveness of anticancer activity increased from ethanol to ethyl acetate ton-hexane fraction. This work underlines the potential ofn-hexane fraction as a chemotherapeutic drug. These novel results have important implications for further isolation, identification, and characterization ofPsidium guajavaL.-based anti-cancer extracts.
A characterization of the simple Ree groups 2𝐹4(𝑞2) by their character codegrees
Authors: Yang Yong 
Published: August 2023

Abstract
The codegree of a character 𝜒 of a finite group 𝐺 is

cod
⁡

(
χ
)

:=

|

G
:

ker
⁡

(
χ
)

|

χ
⁢

(
1
)

.

\operatorname{cod}(\chi):=\frac{\lvert G:\ker(\chi)\rvert}{\chi(1)}.

We show that the set of codegrees of the Ree groups

F
4

2

⁢

(

q
2

)

{}^{2}F_{4}(q^{2})

(

q
2

=

2

2
⁢
n

+
1

q^{2}=2^{2n+1}

,

n
≥
1

n\geq 1

) determines the groups up to isomorphism.
Qua-Objects, (Non-)Derivative Properties and the Consistency of Hylomorphism
Authors: Campdelacreu Marta , Oms Sergi 
Published: August 2023

Abstract
Imagine a sculptor who molds a lump of clay to create a statue. Hylomorphism claims that the statue and the lump of clay are two different colocated objects that have different forms, even though they share the same matter. Recently, there has been some discussion on the requirements of consistency for hylomorphist theories. In this paper, we focus on an argument presented by Maegan Fairchild, according to which a minimal version of hylomorphism is inconsistent. We argue that the argument is unsound or, at best, it just points to a well-known problem for hylmorphist theories. Additionally, we explore some general consequences of this fact.
Synthesis and crystal structure of (3E,5S,10S,13S,14S,17Z)-17-ethylidene-10,13-dimethylhexadecahydro-3H-cyclopenta[α] phenanthren-3-one O-(4-fluorobenzoyl) oxime, C28H36FNO2
Authors: Yue Lan , Wei Peng , Ye Jiang-Hei , He Kang , Zou Juan 
Published: August 2023

Abstract
C28H36FNO2, orthorhombic, P212121 (no. 19), a = 6.3277(3) Å, b = 11.9665(19) Å, c = 32.2419(19) Å, V = 2441.4(2) Å3, Z = 4, R
gt(F) = 0.0537, wR
ref(F
2) = 0.1403, T = 273(2) K.
National Identity in Media Discourses from Russia and Ukraine: Amid the 2022 Russo-Ukrainian War
Authors: Xu Bangjun , Tao Yuan 
Published: August 2023

Summary
This paper, based on the corpus of the news from TASS and UKRINFORM between February 24 and March 5, 2022, investigates different concerns of the two media platforms regarding conflict discourses, and analyzes their different naming strategies of social actors from the perspective of critical discourse analysis (CDA). It is found that Russian and Ukrainian media attempted to construct different national identities for each other through distinct discourse strategies. The Russian TASS named Ukraine a security threat while including Donbas as Russia’s in-group member. It also utilized out-group discourse strategies to exclude western countries, such as the United States, from its friend circle. The Ukrainian media discourse from UKRINFORM, however, grouped Ukraine itself together with western countries allied with the United States while stigmatizing Russia and excluding the Donbas region. The current research shows that the politically driven principle is commonly used in the media discourses from TASS and UKRINFORM as the representative national media of the two countries.