bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pendampingan Wali Murid Paud Aisyiyah Bumirejo Dalam Meningkatkan Kesehatan Anak Untuk Mencegah Stunting
Authors: Handayani Estrin , Nabila Shafiyah , Saputri Nadya Aprilia , Salsabila Zahra Putri , Musyaffa Farhan Fatkhi 
Published: May 2023

Abstract: The high number of stunting incidents is a concern of the government. Some of the causes of stunting are a lack of intake that is absorbed by the body starting from still in the womb until after birth, lack of access to health services, and lack of access to clean water and sanitation. Therefore, it is necessary to make efforts to prevent stunting by improving diet, parenting, and sanitation. With the problem of stunting cases still being high in the Magelang Regency area and it was noted that in the Pedak Bumirejo Village area, Mungkid District, there were still cases of stunting, the Integrated Community Service team at the Muhammadiyah University of Magelang will conduct training for the parents of PAUD Aisyiyah Bumirejo students. The UNIMMA PPMT team will implement the assistance of parents and teachers of PAUD Aisyiyah Bumirejo as a specific nutrition intervention effort for children. This activity aims to reduce the number of stunting cases in the Pedak Bumirejo area, Mungkid District, Magelang Regency.Keywords: Stunting, Child nutrition, PHBS, PAUD Aisyiyah Bumirejo, ParentsAbstrak: Tingginya angka kejadian stunting menjadi perhatian pemerintah. Beberapa penyebab stunting itu sendiri adalah kurangnya asupan yang diserap oleh tubuh mulai dari masih didalam kandungan sampai dengan setelah lahir, kurangnya akses ke pelayanan kesehatan, kurangnya akses air bersih dan sanitasi. Oleh karena itu perlu dilakukan upaya pencegahan stunting dengan perbaikan pola makan, pola asuh dan sanitasi. Dengan permasalahan kasus stunting yang masih tinggi di wilayah Kabupaten Magelang dan tercatat bahwa di wilayah Desa Pedak Bumirejo Kecamatan Mungkid masih ada kasus stunting, maka tim Pengabdian Pada Masyarakat Terpadu Universitas Muhammadiyah Magelang, akan melaksanakan pelatihan bagi para wali murid PAUD Aisyiyah Bumirejo. Tim PPMT UNIMMA ini akan menerapkan pendampingan Wali murid dan guru PAUD Aisyiyah Bumirejo sebagai upaya intervensi gizi spesifik pada anak. Tujuan dari kegiatan ini adalah mengurangi angka kasus stunting di wilayah Pedak Bumirejo Kecamatan Mungkid Kabupaten Magelang. Kata Kunci: Stunting, Gizi anak, PHBS, PAUD Aisyiyah Bumirejo, Orangtua
PENGARUH KONSUMSI BAWANG PUTIH (Allium sativum) TERHADAP TEKANAN DARAH PADA WANITA LANJUT USIA DENGAN HIPERTENSI DI WILAYAH KERJA PUSKESMAS TAKTAKAN KOTA SERANG
Authors: Siti rochmah Siti rochmah , Suprihatin  , Jenny Anna Siauta  
Published: May 2023

Hipertensi mempunyai dampak lanjut Penyakit Jantung Koroner (PJK) serta dapat menimbulkan komplikasi penyakit lain yang berbahaya jika dibiarkan tanpa perawatan yang tepat. Penanganan hipertensi dapat dilakukan dengan teknik farmakologi dan non farmakologi salah satunya dengan pemberian air perasan bawang putih.
Dalam penelitian ini bertujuan untuk mengetahui pengaruh konsumsi bawang putih terhadap tekanan darah pada lansia dengan hipertensi di wilayah kerja Puskesmas Taktakan Kota Serang. Desain penelitian menggunakan metode penelitian quasy experimental design ini menggunakan pendekatan one group pretest-postest design. Sampel dikumpulkan menggunakan quota sampling berjumlah 22 lansia wanita dengan hipertensi. Lembar observasi yang digunakan untuk mengukur penurunan tekanan darah lansia sebelum dan sesudah pemberian bawang putih. Analisa data dilakukan dengan uji non-parametrik yaitu uji wilcoxon dan uji Mann Whitney. Hasil Penelitian diperoleh Rata-rata tekanan darah sistolik pada penderita hipertensi sebelum mengkonsumsi bawang putih 169,55 mmHg dan sesudah mengkonsumsi bawang putih 136,82 mmHg. Sedangkan Rata-rata tekanan darah diastolik pada penderita hipertensi sebelum mengkonsumsi bawang putih 99,55 mmHg dan sesudah mengkonsumsi bawang putih 85,00 mmHg. Kesimpulan penelitian ini konsumsi bawang putih berpengaruh terhadap penurunan tekanan darah pada lansia dengan hipertensi. Diharapkan kepada masyarakat agar mampu memanfaatkan bawang putih sebagai salah satu obat herbal yang bermanfaat bagi kesehatan khususnya untuk penurunan tekanan darah bagi penderita hipertensi

Kata Kunci : lansia, hipertensi, bawang putih
PENGARUH REBUSAN CACING AFRICAN NIGHT CRAWLER TERHADAP PERTUMBUHAN BAKTERI SALMONELLA THYPI
Authors: Aini  
Published: May 2023

Previous studies have conducted experiments using earthworms. The results showed that earthworms were able to inhibit the growth of Salmonella typhi bacteria. The purpose of this study was to determine the effect of different concentrations of boiled water for African night crawler earthworms on the resulting inhibition zone.
The type of research used is experimental research. The population of this study was the African night crawler worm in Narmada District. The sample of this study was the African night crawler worm in Batu Kantar Hamlet, Narmada Village, Narmada District.The conclusion of this study was that there was no effect of different concentrations of boiled water for African night crawler earthworms on the inhibition zone including the medium inhibition zone formed in the first treatment until the fifth treatment was different, this happened because of the difference in thickness and thickness of the pure strain of Salmonella typhosa on the media. Muller Hinton Agar (MHA).
A high ratio of linoleic acid (n-6 PUFA) to alpha-linolenic acid (n-3 PUFA) adversely affects early stage of human neuronal differentiation and electrophysiological activity of glutamatergic neurons in vitro
Authors: Dec Karolina , Alsaqati Mouhamed , Morgan Joanne , Deshpande Sumukh , Wood Jamie , Hall Jeremy , Harwood Adrian J. 
Published: May 2023

Introduction: There is a growing interest in the possibility of dietary supplementation with polyunsaturated fatty acids (PUFAs) for treatment and prevention of neurodevelopmental and neuropsychiatric disorders. Studies have suggested that of the two important classes of polyunsaturated fatty acids, omega-6 (n-6) and omega-3 (n-3), n-3 polyunsaturated fatty acids support brain development and function, and when used as a dietary supplement may have beneficial effects for maintenance of a healthy brain. However, to date epidemiological studies and clinical trials on children and adults have been inconclusive regarding treatment length, dosage and use of specific n-3 polyunsaturated fatty acids. The aim of this study is to generate a simplified in vitro cell-based model system to test how different n-6 to n-3 polyunsaturated fatty acids ratios affect human-derived neurons activity as a cellular correlate for brain function and to probe the mechanism of their action.Methods: All experiments were performed by use of human induced pluripotent stem cells (iPSCs). In this study, we examined the effect of different ratios of linoleic acid (n-6) to alpha-linolenic acid in cell growth medium on induced pluripotent stem cell proliferation, generation of neuronal precursors and electrophysiology of cortical glutamatergic neurons by multielectrode array (MEA) analysis.Results: This study shows that at a n-6:n-3 ratio of 5:1 polyunsaturated fatty acids induce stem cell proliferation, generating a large increase in number of cells after 72 h treatment; suppress generation of neuronal progenitor cells, as measured by decreased expression of FOXG1 and Nestin in neuronal precursor cells (NPC) after 20 days of development; and disrupt neuronal activity in vitro, increasing spontaneous neuronal firing, reducing synchronized bursting receptor subunits. We observed no significant differences for neuronal precursor cells treated with ratios 1:3 and 3:1, in comparison to 1:1 control ratio, but higher ratios of n-6 to n-3 polyunsaturated fatty acids adversely affect early stages of neuronal differentiation. Moreover, a 5:1 ratio in cortical glutamatergic neurons induce expression of GABA receptors which may explain the observed abnormal electrophysiological activity.
Activation of Kupffer cells in NAFLD and NASH: mechanisms and therapeutic interventions
Authors: Xu Gao-Xin , Wei Song , Yu Chao , Zhao Si-Qi , Yang Wei-Jun , Feng Yong-Heng , Pan Chao , Yang Kun-Xing , Ma Yong 
Published: May 2023

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are emerging as the leading causes of liver disease worldwide. These conditions can lead to cirrhosis, liver cancer, liver failure, and other related ailments. At present, liver transplantation remains the sole treatment option for end-stage NASH, leading to a rapidly growing socioeconomic burden. Kupffer cells (KCs) are a dominant population of macrophages that reside in the liver, playing a crucial role in innate immunity. Their primary function includes phagocytosing exogenous substances, presenting antigens, and triggering immune responses. Moreover, they interact with other liver cells during the pathogenesis of NAFLD, and this crosstalk may either delay or exacerbate disease progression. Stimulation by endogenous signals triggers the activation of KCs, resulting in the expression of various inflammatory factors and chemokines, such as NLRP3, TNF-α, IL-1B, and IL-6, and contributing to the inflammatory cascade. In the past 5 years, significant advances have been made in understanding the biological properties and immune functions of KCs in NAFLD, including their interactions with tissue molecules, underlying molecular mechanisms, signaling pathways, and relevant therapeutic interventions. Having a comprehensive understanding of these mechanisms and characteristics can have enormous potential in guiding future strategies for the prevention and treatment of NAFLD.
Evaluation of the relationship between left atrial strain and exercise tolerance in patients with hypertrophic cardiomyopathy by treadmill stress echocardiography
Authors: Su Ye , Li Chunmei , Yin Lixue 
Published: May 2023

ObjectiveThe aim of this study is to evaluate the left atrial strain (LAS) in patients with hypertrophic cardiomyopathy (HCM) by treadmill exercise stress echocardiography, combined with three-dimensional speckle tracking technology, for predicting exercise tolerance.MethodsA total of 97 patients with HCM who underwent treadmill exercise stress echocardiography were recruited in Sichuan Provincial People's Hospital between January 2018 and January 2021, and 30 control subjects were selected to be included in the normal group. HCM patients with their metabolic equivalents (METS) ≤ 6.0 were included in the HCM-1 group, while those with METS &gt; 6.0 were included in the HCM-2 group. The LAS and exercise tolerance were analyzed. The ultrasound parameters that could predict a decrease in exercise tolerance were screened, and a predictive model was constructed.ResultsIt was found that METS, Rest-LASr, Rest-LAScd, and Rest-LASct were significantly lower in HCM patients than those in normal controls. There was a significant difference in age, Target_HR, LVMI, LAVI, E/e'-Rest, E/e'-Peak, Rest-LASr, Rest-LAScd, and Rest-LASct between the HCM-1 and the HCM-2 groups. LASr is an independent resting echocardiographic predictor of METS ≤ 6.0. LASr remained significant for predicting different subtypes (AHCM, asymmetric HCM, and obstructive HCM). Rest-LASr (AUC 0.990) was better at predicting METS ≤ 6.0 than Peak-E/e' (AUC 0.753). A multivariate model (LASr + Age + Target_HR) was established for METS prediction.ConclusionLeft atrial reservoir strain (LASr) has the strongest association with METS ≤ 6.0. The LASr is an independent resting predictor of METS ≤ 6.0 and has a good performance record in predicting different subtypes of HCM. Compared with the traditional parameters, Peak-E/e' and Rest-E/e', Rest-LASr is the best predictor. Rest-LASr can serve as a reliable method for HCM patients who are unable to undergo exercise testing but require an urgent evaluation of their METS, which provides a basis for clinical treatment decision-making and treatment effect evaluation.
Characteristic identification of seismogenic electromagnetic anomalies based on station electromagnetic impedance
Authors: Fan Ye , Hu Wenbao , Han Bing , Tang Ji , Wang Xiao , Ye Qing 
Published: May 2023

The main components of seismo-electromagnetic research are the deep underground electromagnetic seismogenic environment, electromagnetic field changes at different stages of the seismogenic process, and the physical mechanism and change rules of electromagnetic properties of the earth’s interior. Traditional electric and magnetic methods mainly analyze the single field change of the geoelectric field, geomagnetic field, or resistivity at frequencies less than 1 Hz. These do not include the extremely low-frequency band that is sensitive to seismic events, so it is difficult to obtain the characteristics of time-spatial variations and propagation characteristics precursors. In comparison, magnetotelluric stations observe magnetotelluric fields containing seismogenic-induced electromagnetic disturbances, and the observation frequency band is wide. In this paper, the three-dimensional numerical simulation method is used to calculate the magnetotelluric apparent resistivity anomaly generated by resistivity changes in the seismogenic zone, and the forward algorithm of arbitrarily orientated dipole source in layered earth is used to simulate the response of low-frequency pre-earthquake electromagnetic radiation. The magnetotelluric response including seismogenic resistivity anomaly and pre-earthquake electromagnetic radiation is obtained using the field component composition method. The frequency characteristics and spatial distribution characteristics of apparent resistivity anomalies are systematically analyzed, and the results are of important significance for the observation, data processing, and identification and analysis of seismic electromagnetic anomalies in different seismogenic processes.
Testicular dysfunction at diagnosis in children and teenagers with haematopoietic malignancies improves after initial chemotherapy
Authors: Lopez Dacal Jimena , Prada Silvina , Correa Brito Lourdes , Ropelato Maria Gabriela , Ballerini Maria Gabriela , Rodriguez Maria Eugenia , Gutiérrez Marcela E. , Soria Marcela , Morán Lorena , Ferraro Cristina , Bedecarrás Patricia , Drelichman Guillermo , Aversa Luis , Bergadá Ignacio , Rey Rodolfo A. , Grinspon Romina P. 
Published: May 2023

IntroductionHematopoietic malignancies are the most frequent type of cancer in childhood. Recent advances in cancer treatment have significantly improved survival until adulthood. There is an extensive literature on the effects of cancer treatment on the gonadal axis in adult survivors of childhood cancer mainly focused on sperm production, but scarce information exists on the immediate impact of cancer and its treatment in boys.ObjectivesIn this work, we determined the status of the hypothalamic-pituitary-testicular (HPT) axis function at diagnosis and the immediate impact of chemotherapy at the start of treatment in children and adolescents with hematopoietic malignancies.Subjects and methodsIn a prospective study of 94 boys and adolescents with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML) or non-Hodgkin lymphoma (NHL), we determined serum AMH, inhibin B and FSH to assess the gonadotrophin-Sertoli cell component of the HPT axis, and testosterone and LH to evaluate the gonadotrophin-Leydig cell component, at diagnosis and after 3 months of chemotherapy. Secondarily, the general health state was evaluated.ResultsIn prepubertal boys, at diagnosis, AMH, inhibin B and FSH were lower compared to the reference population, reflecting an FSH-Sertoli cell axis dysfunction. After 3 months of chemotherapy, all hormone concentrations increased. At pubertal age, at diagnosis, AMH and inhibin B were lower compared to the reference population for Tanner stage, with inappropriately normal FSH, suggesting a primary Sertoli cell dysfunction with insufficient gonadotrophin compensation. The LH-Leydig cell axis was mildly disrupted. After 3 months of chemotherapy, inhibin B and AMH were unchanged while median FSH levels rose to values that exceeded the reference range, indicating a significant impairment of Sertoli cell function. Testosterone normalized concomitantly with an abnormal LH elevation reflecting a compensated Leydig cell impairment. General health biomarkers were impaired at diagnosis and improved after 3 months.ConclusionThe HPT axis function is impaired in boys with hematopoietic malignancies before the initiation of chemotherapy. There is a primary testicular dysfunction and a concomitant functional central hypogonadism that could be due to an impaired overall health. The HPT axis function improves during the initial 3 months of chemotherapy concomitantly with the general health state. However, in pubertal boys the dysfunction persists as shown by elevated gonadotropin levels after 3 months.
High carrier frequency of a nonsense p.Trp230* variant in HSD3B2 gene in Ossetians
Authors: Makretskaya Nina , Kalinchenko Natalia , Tebieva Inna , Ionova Sofya , Zinchenko Rena , Marakhonov Andrey , Tiulpakov Anatoly 
Published: May 2023

BackgroundCongenital adrenal hyperplasia (CAH) caused by 3β-HSD deficiency is a rare form of congenital adrenal deficiency with an autosomal recessive type of inheritance. Previously we have demonstrated that a single nucleotide variant (SNV) p.Trp230* in the homozygous state is a frequent cause of CAH among the indigenous population of North Ossetia-Alania represented by Ossetians.MethodsGenotyping of the NM_000198.3:c.690G&gt;A p.Trp230* variant was performed by Real-time PCR. 339 healthy individuals of Ossetian origin were included in the study. Allele frequencies, Fisher’s confidence intervals (CI) were calculated using the WinPepi v. 11.65 software. Comparison of allele frequencies was performed with the z-score test for two proportions.ResultsEight heterozygous carriers of c.690G&gt;A variant in HSD3B2 gene were detected in 339 samples investigated. The total allele frequency of p.Trp230* variant was 0.0118 (n=8/678, 95% CI=0.0051–0.0231). Accordingly, the heterozygous carrier rate was 0.0236 (n=8/339). The frequency of CAH caused by p.Trp230* variant in HSD3B2 in Ossetian population was 1:7183 or 13.9 per 100,000 (95% CI: 1:1874–1:38447 or 3–53 per 100,000).ConclusionThe results demonstrate high frequency of p.Trp230* variant in Ossetians, which is most likely attributed to a founder effect.
Distinct serum steroid profiles between adrenal Cushing syndrome and Cushing disease
Authors: Gao Chang , Ding Li , Zhang Xiaona , Yuan Menghua , Tang Shaofang , Li Wei , Ye Yuanyuan , Liu Ming , He Qing 
Published: May 2023

BackgroundDifferentiating between adrenal Cushing syndrome (adrenal CS) and Cushing disease (CD) can be challenging if there are equivocal or falsely elevated adrenocorticotropic hormone (ACTH) values. We aim to investigate the diagnostic value of serum steroid profiles in differentiating adrenal CS from CD.MethodA total of 11 serum steroids in adrenal CS (n = 13) and CD (n = 15) were analyzed by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Age- and gender-specific steroid ratios were generated by dividing the actual steroid concentration by the upper limit of the relevant reference range. A principal component analysis (PCA) and an orthogonal partial least squares discriminant analysis (OPLS-DA) were performed.ResultsThe PCA and OPLS-DA analyses showed distinct serum steroid profiles between adrenal CS and CD. Dehydroepiandrosterone sulfate (DHEA-S), dehydroepiandrosterone (DHEA), and androstenedione ratios were identified as biomarkers for discrimination by variable importance in projection (VIP) in combination with t-tests. The sensitivity and specificity of DHEA-S ratios &lt;0.40 were 92.31% (95% CI 64.0%–99.8%) and 93.33% (95% CI 68.1%–99.8%), respectively, in identifying adrenal CS. The sensitivity and specificity of DHEA ratios &lt;0.18 were 100% (95% CI 75.3%–100.0%) and 100% (95% CI 78.2%–100.0%), respectively, in identifying adrenal CS.ConclusionOur data support the clinical use of the DHEA-S and DHEA ratios in the differential diagnosis of adrenal CS and CD, especially when falsely elevated ACTH is suspected.
FABP3, FABP4, and heart rate variability among patients with chronic schizophrenia
Authors: Hung Wei-Chin , Yu Teng-Hung , Wu Cheng-Ching , Lee Thung-Lip , Tsai I-Ting , Hsuan Chin-Feng , Chen Chun-Yu , Chung Fu-Mei , Lee Yau-Jiunn , Tang Wei-Hua 
Published: May 2023

IntroductionThe prevalence of cardiovascular disease (CVD) and CVD-related deaths in patients with schizophrenia is high. An elevated risk of CVD has been associated with low heart rate variability (HRV). There is increasing evidence that fatty acid-binding protein (FABP)3 and FABP4 play roles in the development and progression of CVD. This study aimed to explore the association of circulating FABP3/FABP4 levels with HRV in patients with chronic schizophrenia.MethodsWe included 265 consecutive patients with chronic schizophrenia who attended a disease management program. We used an enzyme-linked immunosorbent assay for the measurement of plasma concentrations of FABP3 and FABP4. Standard HRV was recorded at baseline following a standard protocol. Mean high- and low-frequency (HF/LF) HRV values were analyzed by tertile of FABP3 and FABP4 using one-way analysis of variance, and linear regression analysis was performed to assess trends.ResultsA positive association between FABP3 and creatinine was found in multiple regression analysis. In addition, negative associations between levels of hematocrit, hemoglobin, HF HRV, and estimated glomerular filtration rate (eGFR) with FABP3 were also found. Moreover, positive associations between FABP4 with body mass index, diabetes mellitus, hypertension, systolic blood pressure, low-density lipoprotein-cholesterol, triglycerides, creatinine, and FABP3 were found. Furthermore, negative associations between levels of high-density lipoprotein-cholesterol, eGFR, and HF HRV with FABP4 were found. We also found a significant inverse association between FABP3 and HF HRV (p for trend = 0.008), and significant inverse associations between FABP4 with HF and LF HRV (p for trend = 0.007 and 0.017, respectively).DiscussionTogether, this suggests that elevated levels of FABP3 and FABP4 may be linked to health problems related to CVD in patients with chronic schizophrenia.