bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of cognitive behavioural therapy for insomnia in people with comorbid insomnia and sleep apnoea: A systematic review and meta‐analysis
Authors: Sweetman Alexander , Farrell Seamas , Wallace Douglas M. , Crawford Megan 
Published: March 2023

SummaryComorbid insomnia and sleep apnoea (COMISA) is a highly prevalent and debilitating sleep disorder. Cognitive behavioural therapy for insomnia (CBTi) may be an appropriate treatment for COMISA; however, no previous study has systematically reviewed and meta‐analysed literature reporting on the effect of CBTi in people with COMISA. A systematic literature search was conducted across PsychINFO and PubMed (n = 295). In all, 27 full‐text records were independently reviewed by at least two authors. Forward‐ and backward‐chain referencing, and hand‐searches were used to identify additional studies. Authors of potentially eligible studies were contacted to provide COMISA subgroup data. In total, 21 studies, including 14 independent samples of 1040 participants with COMISA were included. Downs and Black quality assessments were performed. A meta‐analysis including nine primary studies measuring the Insomnia Severity Index indicated that CBTi is associated with a large improvement in insomnia severity (Hedges’ g = −0.89, 95% confidence interval [CI] −1.35, −0.43). Subgroup meta‐analyses indicated that CBTi is effective in samples with untreated obstructive sleep apnoea (OSA) (five studies, Hedges’ g = −1.19, 95% CI −1.77, −0.61) and treated OSA (four studies, Hedges’ g = −0.55, 95% CI −0.75, −0.35). Publication bias was evaluated by examining the Funnel plot (Egger's regression p = 0.78). Implementation programmes are required to embed COMISA management pathways in sleep clinics worldwide that currently specialise in the management of OSA alone. Future research should investigate and refine CBTi interventions in people with COMISA, including identifying the most effective CBTi components, adaptations, and developing personalised management approaches for this highly prevalent and debilitating condition.
Forecasting inflation with a zero lower bound or negative interest rates: Evidence from point and density forecasts
Authors: Anderl Christina , Caporale Guglielmo Maria 
Published: March 2023

AbstractThis paper investigates the predictive power of the shadow rate for the inflation rate in countries with a zero lower bound (the US, the UK and Canada) and in those with negative rates (Japan, the Euro Area and Switzerland). Using shadow rates obtained from two different models (the WX(3) and the KANSM(2) ones) and for different LB parameters we compare the out‐of‐sample forecasting performance of an inflation model including a shadow rate with a benchmark one excluding it. Both specifications are estimated by OLS (Ordinary Least Squares) and includes a range of macroeconomic factors computed by means of principal component analysis. Both point and density forecasts of the inflation rate are evaluated. The models including the shadow rate are found to outperform the benchmark ones according to both sets of criteria except in countries operating an official inflation targeting regime. Both types of shadow rates appear to produce equally accurate out‐of‐sample inflation forecasts.
Are wearable electronic vision enhancement systems (wEVES) beneficial for people with age‐related macular degeneration? A scoping review
Authors: Miller Andrew , Crossland Michael D. , Macnaughton Jane , Latham Keziah 
Published: March 2023

AbstractIntroductionAge‐related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the United Kingdom. It has a wide‐ranging detrimental impact on daily living, including impairment of functional ability and quality of life. Assistive technology designed to overcome this impairment includes wearable electronic vision enhancement systems (wEVES). This scoping review assesses the usefulness of these systems for people with AMD.MethodsFour databases (Cumulative Index to Nursing and Allied Health Literature, PubMed, Web of Science and Cochrane CENTRAL) were searched to identify papers that investigated image enhancement with a head‐mounted electronic device on a sample population that included people with AMD.ResultsThirty‐two papers were included: 18 studied the clinical and functional benefits of wEVES, 11 investigated use and usability and 3 discussed sickness and adverse effects.ConclusionsWearable electronic vision enhancement systems provide hands‐free magnification and image enhancement producing significant improvements in acuity, contrast sensitivity and aspects of laboratory‐simulated daily activity. Adverse effects were infrequent, minor and spontaneously resolved with the removal of the device. However, when symptoms arose, they sometimes persisted with continued device usage. There are multi‐factorial influences and a diversity of user opinions on promotors to successful device use. These factors are not exclusively driven by visual improvement and incorporate other issues including device weight, ease of use and inconspicuous design. There is insufficient evidence of any cost–benefit analysis for wEVES. However, it has been shown that a user's decision to make a purchase evolves over time, with their estimates of cost falling below the retail price of the devices. Additional research is needed to understand the specific and distinct benefits of wEVES for people with AMD. Further patient‐centred research should assess the benefits of wEVES in user‐led activities when directly compared with alternative coping strategies, allowing professionals and users to make better prescribing and purchasing decisions.
Resistance to evidence and the duty to believe
Authors: Simion Mona 
Published: March 2023

AbstractThis article develops and defends a full account of the nature and normativity of resistance to evidence, according to which resistance to evidence is an instance of input‐level epistemic malfunctioning. At the core of this epistemic normative picture lies the notion of knowledge indicators, as evidential probability increasing facts that one is in a position to know; resistance to evidence is construed as a failure to uptake knowledge indicators.
The future of intensive tilapia production and the circular bioeconomy without effluents: Biofloc technology, recirculation aquaculture systems, bio‐RAS, partitioned aquaculture systems and integrated multitrophic aquaculture
Authors: Zimmermann Sergio , Kiessling Anders , Zhang Jiasong 
Published: March 2023

AbstractModern tilapia farming with low use of water aims, as in circular bioeconomy, to reduce inputs and fully reuse waste and effluents, closing flows or links of economic and ecological resources and decentralizing production systems (local production and local consumption). Concerns over diseases, market demand for a clean, sustainable and ecologically correct aquaculture, with greater and more efficient controls, increased predictability and repeatability of activities, are leading to a series of structural changes in the reuse of water and effluents through various closed recirculation systems with the reuse of waste as nutrients. In recent decades, one of the most important innovations and trends of tilapia culture is towards circular bioeconomy, characterized in this review by several recirculation systems, such as biofloc technology (BFT), recirculation aquaculture systems (RASs), bio‐RAS, partitioned aquaculture systems (PASs with split ponds, SPs; and in pond recirculation system, IPRS) and integrated multitrophic aquaculture (IMTA). The future of tilapia culture meshes with urban agriculture and waste fermentation, where low‐demand water recirculation systems will be the protagonists in the disruption of industries in five main sectors (materials, energy, information, transport and food/health), that still today focus on extraction, into a more sustainable local model.
Feed‐food competition in global aquaculture: Current trends and prospects
Authors: van Riel Anne‐Jo , Nederlof Marit A. J. , Chary Killian , Wiegertjes Geert F. , de Boer Imke J. M. 
Published: March 2023

AbstractFeed‐food competition is the allocation of resources that can be used to feed humans to animal feed instead, a current but unsustainable practise not well documented for aquaculture. Here, we analysed feed‐food competition in aquaculture using two measures; natural trophic levels (TLs) and species‐specific human‐edible protein conversion ratios (HePCRs). The HePCR equals the ratio of human edible protein in feed (input) to the human edible protein in animal produce (output). To provide prospects on aquaculture's potential to convert human inedible by‐products into edible biomass, data on aquaculture production were collected and categorized based on natural TLs. HePCRs were computed for four aquaculture species produced in intensive aquaculture systems: Atlantic salmon, common carp, Nile tilapia and whiteleg shrimp. Under current feed use, we estimated that the carp, tilapia and shrimp considered were net contributors of protein by requiring ~0.6 kg of human edible protein to produce 1 kg of protein in the fillet/meat. Considering soya bean meal and fishmeal as food‐competing ingredients increased the HePCR to ~2 and turned all of the case‐study species into net consumers of protein. To prevent this increase, the use of high‐quality food‐competing ingredients such as fishmeal, or soya bean products should be minimized in aquaculture feed. In the future, the role of aquaculture in circular food systems will most likely consist of a balanced mix of species at different TLs and from different aquaculture systems, depending on the by‐products available.
Subclinical atherosclerosis in patients with hidradenitis suppurativa treated with TNF inhibitors
Authors: Oba Muazzez Cigdem , Askin Ozge , Gunver Mehmet Guven , Kocaarslan Gokce , Alis Deniz Can , Engin Burhan 
Published: March 2023

AbstractBackgroundHidradenitis suppurativa (HS) is an independent risk factor for the development of subclinical atherosclerosis. Tumour necrosis factor (TNF) inhibitors are effective for the treatment of recalcitrant moderate‐to‐severe HS. However, the effect of treatment with TNF inhibitors on subclinical atherosclerosis in HS patients has not been previously investigated.ObjectivesIn this study, we aimed to assess changes in biochemical parameters (fasting blood glucose and lipid levels) and carotid intima‐media thickness (CIMT) values in Hurley stage II and III HS patients undergoing treatment with TNF inhibitors.MethodsThis was a single center prospective study including 30 patients with Hurley stage II and III HS and 30 healthy controls (HCs). Baseline values of biochemical parameters and CIMT were compared to the values recorded after at least 6 months of TNF inhibitor therapy.ResultsCIMT values of the HS patients significantly exceeded those of HCs (for right p = 0.011 and for left p = 0.017). After at least 6 months of TNF inhibitor therapy, there was a statistically significant decrease in fasting blood glucose (p = 0.001), whereas total cholesterol levels significantly increased (p = 0.001). CIMT values also significantly increased (for right p = 0.02 and for left p = 0.01).Study limitations and conclusionsSmall sample size is limitation of the current study. Our study shows that patients with Hurley stage II and III HS undergoing TNF inhibitor therapy are under risk for progression of subclinical atherosclerosis.
Standard and modified glabellar flap for medial canthus reconstruction following mass removal in three dogs and two cats
Authors: Sarfaty Havi , Ezra‐Elia Raaya , Kahane Nili , Sandalon Shai , Segev Yifat , Sebbag Lionel 
Published: March 2023

AbstractPurposeTo describe the surgical technique and clinical outcomes of the glabellar flap and its modification for the reconstruction of the medial canthus following resection of tumors in three dogs and two cats.MethodsThree dogs (7‐, 7‐, and 12.5‐year‐old mixed breeds) and two cats (10‐ and 14‐year‐old Domestic shorthair) presented with a 7–13 mm tumor affecting the eyelid and/or conjunctiva in the medial canthal region. Following en bloc mass excision, an inverted V‐shaped skin incision was made in the glabellar region (i.e., the area between the eyebrows in humans). The apex of the inverted V‐shaped flap was rotated in three cases, whereas a horizontal sliding movement was performed in the other two cases to better cover the surgical wound. The surgical flap was then trimmed to fit the surgical wound and sutured in place in two layers (subcutaneous and cutaneous).ResultsTumors were diagnosed as mast cell tumors (n = 3), amelanotic conjunctival melanoma (n = 1), and apocrine ductal adenoma (n = 1). No recurrence was noted in a follow‐up time of 146 ± 84 days. Satisfactory cosmetic outcome with normal eyelids closure was achieved in all cases. Mild trichiasis was present in all patients and mild epiphora was noted in 2/5 patients, but there were no associated clinical signs such as discomfort or keratitis.ConclusionsThe glabellar flap was easy to perform and provided a good outcome in terms of cosmetic, eyelid function, and corneal health. Postoperative complications from trichiasis appear to be minimized by the presence of the third eyelid in this region.
Finding solutions for the management of e-waste on Otago University’s Dunedin campus
Authors: Fatima Faiqua 
Published: March 2023

Electronic waste is a matter of increasing concern in many countries. Ewaste comprises of inoperative laptops, tablets, batteries, etc. that must be disposed of safely. Global statistics show that in 2019, 53.6 million metric tons of e-waste was created. E-waste consists of chemicals and metals, if disposed with food waste and general waste, this waste can turn toxic and harm human and environmental health by polluting the environment by leaching of lead, mercury, and arsenic. Therefore, it is important to minimise electronic waste generated to ultimately minimise the risk of pollution and maintain a standard of sustainability. Furthermore, it is important for consumers to understand that e-waste relates to many of the Sustainable Development Goals charted out by the United Nations. This project is based on finding practical solutions to help minimise e-waste and to improve disposal methods at the Dunedin Campus of the University of Otago. Previously, similar projects were undertaken in some universities globally to help tackle e-waste. To find solutions, companies dealing with the disposal of e-waste were approached and their methods were observed, as similar methods could be applied at the university. The project was started by familiarising with the current solutions on campus, including E-waste Recycling Centre and by understanding the material flow. Following which, interviews with select participants took place, where we obtained an understanding of their processes. To finish, a diagram that illustrates the flow of materials was constructed to help with a better understanding of current methods and future methods.
Supervised by Ray O'Brien, Head of Sustainability, Sustainability Office, Univeristy of OtagoScholarship funded by: Waste Management NZ
Food Waste
Authors: Lawrence Demi 
Published: March 2023

This research project explored solutions for food waste reduction and mitigation across Te Whatu Ora / New Zealand Public Hospital systems by looking at the case study of Dunedin Public Hospital. Directly relating and supporting Sustainable Development Goal (SDG) 12.3, to halve global food waste at consumer and retail levels by 2030. This research was done by analysing appropriate literature exploring food and organic waste management strategies in national and international hospital service sectors and systems, further using the Food Recovery Hierarchy as a framework, which ranks the effects of these strategies when looking at them financially, environmentally and socially. Furthermore, this research looks at the barriers and enablers of the suggested organic waste management strategies. A food waste audit was conducted at Dunedin Public Hospital to assess and quantify the current organic waste within the system. The key questions of this study are: How do we prevent organic waste in the first place (preparation strategies)? What can we do with the organic waste produced to prevent it from going to landfills? What items in the food system are the most wasted? How much Greenhouse gas (GHG) is produced by this organic waste going to landfill? Organic waste produces methane, occupies land mass and has the potential for groundwater contamination. Ten per cent of total global GHG Emissions come from food waste, 22% of which is occurring at the consumption level. The key impact of this research is to mitigate organic waste going to landfills to reduce further climate change, thus benefiting environmentally, socially and economically.
Supervised by: Ray O'Brien & Craig Cliff, Sustainability Office, University of OtagoScholarship funded by: Te Whatau Ora Southern
Supplemental Material: Linking Pacific Plate formation and Early Cretaceous metallogenic response on the circum-Pacific continental margins
Authors: Wu Chao , Chen Huayong 
Published: March 2023

<p>Table S1: Materials properties used in 2-D numerical experiments. Figure S1. Numerical modelling results of temperature by I2VIS for Jiaodong of E. China at ca. 120 Ma (A), SE coast of China at ca. 105 Ma (B), North America at ca. 120 Ma (C), South Peru (D), and North Chile at 110 Ma (E). Figure S2: Numerical modelling results of bulk strain by I2VIS for Jiaodong of East China at ca. 120 Ma (A), SE coast of China at c. 105 Ma (B), North America at ca. 120 Ma (C), South Peru (D), and North Chile at 110 Ma (E). Figure S3: Numerical modelling results by I2VIS for present (0 Ma) South America (A) and Solomon Islands (B). Supplemental Text: Reconstructing plate kinetics using GPlates and Rheological model. </p>
Perceived Appropriateness of Assessing for Health-related Socioeconomic Risks Among Adult Patients with Cancer
Authors: Vu Milkie , Boyd Kelly , De Marchis Emilia H. , Garnache Bridgette G. , Gottlieb Laura M. , Gross Cary P. , Lee Nita K. , Lindau Stacy Tessler , Mun Sophia , Winslow Victoria A. , Makelarski Jennifer A. 
Published: March 2023

Abstract

Cancer treatment can trigger or exacerbate health-related socioeconomic risks (HRSR; food/housing insecurity, transportation/utilities difficulties, and interpersonal violence). The American Cancer Society and National Cancer Institute recommend HRSR screening and referral, but little research has examined the perceptions of patients with cancer on the appropriateness of HRSR screening in healthcare settings. We examined whether HRSR status, desire for assistance with HRSRs, and sociodemographic and health care–related factors were associated with perceived appropriateness of HRSR screening in health care settings and comfort with HRSR documentation in electronic health records (EHR). A convenience sample of adult patients with cancer at two outpatient clinics completed self-administered surveys. We used χ2 and Fisher exact tests to test for significant associations. The sample included 154 patients (72% female, 90% ages 45 years or older). Thirty-six percent reported ≥1 HRSRs and 27% desired assistance with HRSRs. Overall, 80% thought it was appropriate to assess for HRSRs in health care settings. The distributions of HRSR status and sociodemographic characteristics were similar among people who perceived screening to be appropriate and those who did not. Participants who perceived screening as appropriate were three times as likely to report prior experience with HRSR screening (31% vs. 10%, P = 0.01). Moreover, 60% felt comfortable having HRSRs documented in the EHR. Comfort with EHR documentation of HRSRs was significantly higher among patients desiring assistance with HRSRs (78%) compared with those who did not (53%, P &lt; 0.01). While initiatives for HRSR screening are likely to be seen by patients with cancer as appropriate, concerns may remain over electronic documentation of HRSRs.

Significance:
National organizations recommend addressing HRSRs such as food/housing insecurity, transportation/utilities difficulties, and interpersonal violence among patients with cancer. In our study, most patients with cancer perceived screening for HRSRs in clinical settings as appropriate. Meanwhile, concerns may remain over the documentation of HRSRs in EHRs.
Patient Characteristics, Outcomes, and Effects of Dapagliflozin According to the Duration of Heart Failure: A Prespecified Analysis of the DELIVER Trial
Authors: Kondo Toru , Jering Karola S. , Borleffs C. Jan Willem , de Boer Rudolf A. , Claggett Brian L. , Desai Akshay S. , Dobreanu Dan , Inzucchi Silvio E. , Hernandez Adrian F. , Janssens Stefan P. , Jhund Pardeep S. , Kosiborod Mikhail N. , Lam Carolyn S.P. , Langkilde Anna Maria , Martinez Felipe A. , Petersson Magnus , Vinh Pham Nguyen , Vaduganathan Muthiah , Solomon Scott D. , McMurray John J.V. 
Published: March 2023

Background:
How patient characteristics and outcomes vary according to the duration of heart failure (HF) is unknown in individuals with mildly reduced or preserved ejection fraction. We compared these, and the efficacy and safety of dapagliflozin, according to the time from diagnosis of HF in a prespecified analysis of the DELIVER trial (Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure).

Methods:
HF duration was categorized as ≤6 months, >6 to 12 months, >1 to 2 years, >2 to 5 years, or >5 years. The primary outcome was the composite of worsening HF or cardiovascular death. The effect of treatment was examined by HF duration category.

Results:

The number of patients in each category was as follows: 1160 (≤6 months), 842 (>6 to 12 months), 995 (>1 to 2 years), 1569 (>2 to 5 years), and 1692 (>5 years). Patients with longer-duration HF were older and had more comorbidities with worse symptoms. The rate of the primary outcome (per 100 person-years) increased with HF duration: ≤6 months, 7.3 (95% CI, 6.3 to 8.4); >6 to 12 months, 7.1 (6.0 to 8.5); >1 to 2 years, 8.4 (7.2 to 9.7); >2 to 5 years, 8.9 (7.9 to 9.9); and >5 years, 10.6 (9.5 to 11.7). Similar trends were seen for other outcomes. The benefit of dapagliflozin was consistent across HF duration category: the hazard ratio for the primary outcome in the ≤6-month group was 0.67 (95% CI, 0.50 to 0.91); >6 to 12 months, 0.78 (0.55 to 1.12); >1 to 2 years, 0.81 (0.60 to 1.09); >2 to 5 years, 0.97 (0.77 to 1.22); and >5 years, 0.78 (0.64 to 0.96;
P
interaction
=0.41). The absolute benefit was greatest in longest-duration HF; the number needed to treat for HF >5 years was 24 versus 32 for ≤6 months.

Conclusions:
Patients with longer-duration HF were older, had more comorbidities and symptoms, and had higher rates of worsening HF and death. The benefits of dapagliflozin were consistent across HF duration. Even patients with long-standing HF and generally mild symptoms are not stable, and it is not too late for such patients to benefit from a sodium–glucose cotransporter 2 inhibitor.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03619213.