bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of mentalization and epistemic trust with internalizing and externalizing problems in adolescence: A gender‐sensitive structural equation modeling approach
Authors: Locati Francesca , Benzi Ilaria Maria Antonietta , Milesi Alberto , Campbell Chloe , Midgley Nicholas , Fonagy Peter , Parolin Laura 
Published: July 2023

AbstractIntroductionMentalization, operationalized as reflective functioning (RF), allows individuals to interpret actions as caused by intentional mental states. Previous research highlighted the gender‐specific associations between adolescents' internalizing and externalizing difficulties and mentalizing impairments. In addition, research suggested that mentalizing facilitates the creation of epistemic trust (ET) to evaluate social information as accurate, reliable, and relevant. However, few investigations explored the concurrent associations between RF, ET, and adolescent psychopathology.MethodsA sample of 447 Italian cisgender adolescents (57% assigned females at birth; age range 12–19 years old; Mage = 15.54, SD = 1.98) self‐reported RF (RFQY‐5), ET towards mother, father, and peers (IPPA) and mental health problems (YSR‐112). Gender‐specific structural equation modeling explored the associations between RF, ET, and internalizing/externalizing problems.ResultsResults suggested an excellent fit for the theoretical model and revealed gender‐related associations. In females, findings suggest that ET mediates the association between RF and psychopathology, with indirect associations from RF through ET to lower internalizing and externalizing problems. However, in males, RF and ET display independent associations with psychopathology.ConclusionOverall, findings suggest that ET might be a transdiagnostic factor playing different roles associated with adolescent psychopathology. Indeed, links between RF and ET might help to explore gender differences in mental health problems in this developmental phase.
TWEAK promotes inflammatory response in liver fibrosis
Authors: Kong Yun , Yang Yi , Wu Shasha , Li Wenyan 
Published: July 2023

AbstractThis study aimed to investigate the role and mechanism of tumor necrosis factor‐like weak inducer of apoptosis (TWEAK) in liver fibrosis. The liver Kupffer cells (KCs) and mononuclear macrophages (J774A.1) were used as the objects of study to induce M1 polarization with LPS/IFN‐γ. After TWEAK intervention, the M1 cell proportion and marker cytokine levels were detected. Thereafter, CD266 expression was silenced, and NLRP3 expression was inhibited by the NLRP3 inhibitor, so as to investigate the impact of TWEAK on M1 polarization of KCs. In addition, the mouse model of liver fibrosis was constructed to observe the influence of TWEAK on mouse liver fibrosis. According to our results, TWEAK promoted M1 polarization of liver KCs and J774A.1 cells, and silencing CD266 expression or treatment with the NLRP3 inhibitor suppressed the effect of TWEAK. In the mouse experiment, it was discovered that after knocking down NLRP3 expression or using NLRP3 inhibitor to antagonize the effect of TWEAK, the mouse liver function and M1 cell level in liver tissues were improved.
MRI Radiomics Features of Adenohypophysis Determine the Activation of Hypothalamic‐Pituitary‐Gonadal Axis in Peri‐Puberty Children
Authors: Liu Dong , Lv Wenzhi , Liu Weiyin Vivian , Tian Tian , Qin Yuanyuan , Li Yakun , Liu Qin , Cai Jianjian , Gao Sikang , Ding Guojun , Zhao Yunyun , Zhou Yiran , Xie Yan , Zhu Wenzhen 
Published: July 2023

BackgroundThe status of the hypothalamic‐pituitary‐gonadal (HPG) axis is important for assessing the onset of physiological or pathological puberty. The reference standard gonadotropin‐releasing hormone (GnRH) stimulation test requires hospital admission and repeated blood samples. A simple noninvasive method would be beneficial.ObjectivesTo explore a noninvasive method for evaluating HPG axis activation in children using an MRI radiomics model.Study TypeRetrospective.PopulationTwo hundred thirty‐nine children (83 male; 3.6–14.6 years) with hypophysial MRI and GnRH stimulation tests, randomly divided a training set (168 children) and a test set (71 children).Field Strength/Sequence3.0 T, 3D isotropic fast spin echo (CUBE) T1‐weighted imaging (T1WI) sequences.AssessmentRadiomics features were extracted from sagittal 3D CUBE T1WI, and imaging signatures were generated using the least absolute shrinkage and selection operator (LASSO) with 10‐fold cross‐validation. Diagnostic performance for differential diagnosis of HPG status was compared between a radiomics model and MRI features (adenohypophyseal height [aPH] and volume [aPV]).Statistical TestsReceiver operating characteristic (ROC) and decision curve analysis (DCA). A P value <0.05 was considered statistically significant.ResultsEight hundred fifty‐one radiomics features were extracted and reduced to 10 by the LASSO method in the training cohort. The radiomics model based on CUBE T1WI showed good performance in assessment of HPG axis activation with an area under the ROC curve (AUC) of 0.81 (95% CI: 0.71, 0.91) in the test set. The AUC of the radiomics model was significantly higher than that of aPH (0.81 vs. 0.65) but there was no significant difference compared to aPV (0.81 vs. 0.78, P = 0.58). In DCA analysis, the radiomics signature showed higher net benefit over the aPV and aPH models.Data ConclusionsThe MRI radiomics model has potential to assess HPG axis activation status noninvasively, potentially providing valuable information in the diagnosis of patients with pathological puberty onset.Evidence Level4Technical EfficacyStage 2
Plasma versus serum for extracellular vesicle (EV) isolation: A duel for reproducibility and accuracy for CNS‐originating EVs biomarker analysis
Authors: Taha Hash Brown 
Published: July 2023

AbstractBlood‐derived extracellular vesicles (EVs) are a popular source of biomarkers for central nervous system (CNS) diseases, but inconsistencies in isolation and analysis hinder their clinical translation. This review summarizes recent studies that investigate the impact of different anticoagulated plasma and serum on the yield, purity, and molecular content of EVs. Specifically, the studies compare ethylenediaminetetraacetic acid (EDTA), citrate, heparin plasma, and serum and highlight the risk of contamination from platelet‐derived EVs. Here, I offer practical guidelines for standardizing EV isolation and analysis, recommending the use of plasma anticoagulated with acid‐citrate‐dextrose (ACD) or citrate followed by EDTA and heparin, subgroup analyses for samples from different biobank repositories, and avoiding serum and plasma‐to‐serum transformation. Other factors like illness, age, gender, meal timing, exercise, circadian timing, and arm pressure during blood draw can alter EV signatures. Yet, how these variables interact with different anticoagulated plasma or serum samples is unclear, necessitating further research. Furthermore, whether the changes are dependent on the isolation or quantification methodology remains an area of investigation. Importantly, the perspective emphasizes the need for consistency in experimental methodologies to improve the reproducibility and clinical applicability of CNS‐originating EV biomarker studies. The proposed guidelines, along with ongoing efforts to standardize blood sample handling and collection, may facilitate the development of more reliable and informative CNS‐originating EV biomarkers for diagnosis, prognosis, and treatment monitoring of CNS diseases.
Liquid‐Core Optical Fibers—A Dynamic Platform for Nonlinear Photonics
Authors: Chemnitz Mario , Junaid Saher , Schmidt Markus A. 
Published: July 2023

AbstractSoftphotonics has emerged as a new discipline that utilizes soft matter (i.e., liquids, gels, bio‐materials) as waveguide materials with versatile functionalities. The flexible properties of soft matter show great potential for further exploiting nonlinear in‐fiber phenomena to gain more insights into their fundamental dynamics and to inspire a new generation of broadband optical light sources and signal processors that are adaptable, reconfigurable, and biocompatible. In particular, incorporating solvents with extraordinary temperature sensitivity, miscibility, and nonlinearity into optical fibers has spawned a series of inventions and fundamental scientific findings over the last decades. This review highlights the current state of development of nonlinear photonics in liquid‐filled fibers. The current state of knowledge in the linear and nonlinear material properties of the most prominent solvents (CS2, CCl4, C2Cl4, benzene and its derivatives) are revisited, and recent advances in nonlinear liquid‐core fiber optics, including a special highlight on phenomena that are unique to liquids, such as modified solitary states and local dispersion control are summarized. Finally, the leading scientific challenges for advancing the field, which highlights liquid‐core fibers as a rich platform for science and technology, are discussed.
THE POWER OF INTERCONNECTION: FRANCES HESSELBEIN IN HER OWN WORDS
Authors: Bailey Darlyne 
Published: July 2023

AbstractThe author, Professor, and Dean Emeritus at Bryn Mawr College's Graduate School of Social Work and Social Research, writes about her long‐standing relationship with Frances Hesselbein. The article revolves around an interview in late 2016 between Bailey and Hesselbein for a special issue of the multidisciplinary journal Reflections: Narratives of Professional Helping. According to the author, the “issue focused on the relationship between the individual and organizations…” and it centers around Hesselbein's professional career, beginning with her leadership of the Girl Scouts of the USA in the mid‐1970s.
THE IMPORTANCE OF LEGACY IN THE LIFE AND WORK OF FRANCES HESSELBEIN
Authors: Dittmar James K. 
Published: July 2023

AbstractThe author, the founder, and director of the M.S. in Organizational Leadership program at Geneva College, writes about his friendship with Frances Hesselbein, a fellow Pennsylvanian. He writes about the importance of legacy and personal/family history within Frances’ work and leadership. This is especially true for her upbringing in the small city of Johnstown. “For Frances,” he writes, legacy “was a direct connection to her past: a past that played a significant role in her maturity as a person and servant leader.” He recounts many years of Frances’ family history, and discusses a tour he and his wife spent with Frances in that area, in which they spent “a memorable day touring various places that were special to Frances.”
GRACE IN CHARACTER, FRANCES HESSELBEIN’S WAY
Authors: Kolditz Tom 
Published: July 2023

AbstractThe author founded the Doerr Institute for New Leaders at Rice University, designed and directed the Leadership Development Program at the Yale School of Management, and was Head of the Department of Behavioral Sciences and Leadership at West Point, retiring as a Brigadier General. He worked directly with Frances Hesselbein at West Point, and recounts that “anyone who knew Frances reveled in her respect for others—one of the Army’s key values. But her ability to demonstrate those values in her controlled, polite, graciousness to others was truly remarkable. In the 21 years, I was privileged to know her, I studied her intently as a leader. Her grace gave her the ability to influence others gently but firmly—“no one can say ‘no’ to Frances” was a popular adage, and the absolute truth.”
HOW A GREAT MENTOR & A GREAT MISSION CAN CHANGE YOUR LIFE AND THE WORLD
Authors: Perez Torin 
Published: July 2023

AbstractThe author, an anti‐racism educator, and Diversity, Equity and Inclusion leader, first met Frances Hesselbein at a book talk in New York City by Joan Kuhl, also an author in this special issue of Leader to Leader. The author and Frances “quickly became friends of the heart,” and his mentor. He recounts that “Frances sat front and center at my TED Talk in 2016, and when I did a keynote in 2018 at my alma mater—Lafayette College in Easton, PA. With both invitations, without hesitation she said “I’ll be there” and in typical Frances fashion she arrived earlier than everyone else so she could get the best seat.” He continues: “You’ve got to find a mentor who believes in you. A mentor who wants you to be heard. A mentor who asks you and knows what your mission is, so they can marvel when you bring that mission to life, and guide you if you go astray.”
FRANCES HESSELBEIN: THE MOST KIND‐HEARTED LEADER OF OUR TIME
Authors: Reiss Robert 
Published: July 2023

AbstractThe author, who conducted over 1,000 interviews on the nationally syndicated The CEO Show, and is Publisher of The CEO Forum Magazine, writes about his friendship with Frances Hesselbein. He recounts particular, lasting memories of their time together, and “that highlight the ways Frances demonstrated that greatness as a leader in her everyday interactions.” He believes that even after turning 100, she “retained the joy of a child” and “stayed so young at heart.” She relished human contact and placed an emphasis on looking one’s best. In the author’s 2013 Forbes article about her, he quotes Frances’ advice for leaders: “Practice self‐awareness, self‐evaluation, and self‐improvement, if we are aware that our manners – language, behavior, and actions – are measured against our values and principles, we are able to more easily embody the philosophy, leadership is a matter of how to be, not how to do.”
FRANCES HESSELBEIN AND PETER DRUCKER: MASTERCLASSES IN PRODUCTIVE LONGEVITY
Authors: Rosenstein Bruce 
Published: July 2023

AbstractThe author is the managing editor of Leader to Leader, who has written two books about Frances Hesselbein's longtime friend and collaborator Peter Drucker. He notes their productive longevity, characterized by each being awarded the Presidential Medal of Freedom, the United States’ highest civilian honor, at an advanced age: Frances at 82 and Peter at 92. The two did not meet and start collaborating until the early 1980s, when Frances was in her mid‐sixties and Peter in his early‐seventies. Frances lived to be 107 and Peter to almost 96. Their professional collaborations are recounted, and legacies are assessed. The author writes that “their striving for excellence resonated with their readers and followers. Their drive for excellence never wavered. And their success was aided by recognizing the limits of aging, and working around those limits.”
THE LESSONS AND LEGACY OF FRANCES HESSELBEIN—MY PERSONAL REFLECTIONS ON A BELOVED MENTOR AND FRIEND
Authors: Shambaugh Rebecca 
Published: July 2023

AbstractThe author is the founder of Women in Leadership and Learning, one of the first leadership development programs for women in the country, and leads her own consulting firm, SHAMBAUGH Leadership. She knew Frances Hesselbein for nearly a quarter century. She notes that “Frances used her strengths generously and selflessly in the service of others, and in doing so, became a driving force shaping timeless leadership principles and management philosophy.” She further recounts indelible impressions of Frances’ quiet power: “She saw in others what was not visible to them and reinforced the power of purpose that is the foundation for what we do and why we thrive. She never failed to leave you with something vital to strive for or do. She always expected you to not only be your best self, but to reach beyond what you thought you were capable of.”
The impact of service robots on consumer response: Examining the roles of consumers' service expertise and technology expertise
Authors: Zheng Xiaoyun , Wang Yao‐Chin , Wei Wei , Zhang Lu , Huo Da 
Published: July 2023

AbstractService robots as an example of service innovation has been of great interest to researchers as it could produce greater value‐in‐use for consumers during service encounters. However, the question of how and why service robots may affect consumers remains inadequately understood. Leveraging service‐dominant logic and the heuristic‐systematic model, Study 1 examines the impacts of service innovation types on brand equity and the moderating role of consumer expertise. Study 2 explores whether cognitive and emotional trust can bridge the underlying mechanism. We find that consumers with higher levels of service expertise rate firms with supportive innovation (vs. interactive innovation) higher in brand equity. On the other hand, service novices rate firms with both types of service innovation similarly. Emotional trust significantly mediates the effect mentioned above. In addition, consumers with high technology expertise will better recognize firms' service innovation efforts regardless of innovation type. Our findings extend the service innovation literature by demonstrating how individual‐level factors such as consumer expertise help explain the relationships between various types of service robots and consumer response. Moreover, we reveal the importance for service brands to invest in different service robots based on target groups and build emotional trust with consumers.
Children's Oncology Group's 2023 blueprint for research: Diversity and health disparities
Authors: Winestone Lena E. , Beauchemin Melissa P. , Bona Kira , Kahn Justine , Prasad Pinki , Robles Joanna M. , Velez Maria C. ,   the Diversity and Health Disparities Committee
Published: July 2023

AbstractThe Children's Oncology Group (COG) Diversity and Health Disparities Committee's (DHDC's) mission is to guarantee the highest standard of care for children and adolescents and young adults (AYA) with cancer regardless of ethnic, racial, gender, or socioeconomic background. We strive to identify and address issues of disparity within the existing scientific structure of COG and to support research across COG to improve survival by ensuring equitable access to COG‐sponsored clinical trials. We are committed to advance COG‐led research identifying mechanistic drivers of disparities and, concurrently, evaluating interventions to alleviate disparities in the COG trial setting. As trials identify the most promising therapies, diverse representation is critical to ensure that findings are relevant to everyone. Factors impacting clinical trial participation among vulnerable populations are complex, consisting of barriers at societal, systems, and individual levels. Recent efforts by investigators within DHDC demonstrated that trial‐embedded collection of family‐reported sociodemographic data and social determinants of health (SDoH) is feasible and acceptable in the context of COG. Diversity in the pediatric oncology workforce is essential and one potential approach to improving representation on clinical trials. To support and retain diverse oncology providers and researchers, a Minority Young Investigator Award (MYIA) was created to facilitate opportunities for graduating trainees and YIs with an interest in childhood cancer disparities research within COG. Although there are challenges to achieve the DHDC's priorities, only through collaboration and support for this work we will be able to elucidate mechanisms underlying inferior survival outcomes for historically marginalized children and AYA, and more importantly, implement interventional investigation to improve outcomes.
In‐depth analysis of the xanthine oxidase inhibitors of Cicer arietinum L.‐based receptor–ligand affinity coupled with complex chromatography
Authors: Hou Wanchao , Niu Huazhou , Liu Zhen , Zhang Yuchi , Li Sainan , Liu Chunming 
Published: July 2023

AbstractIntroductionCicer arietinum L. is the choice of health food for people with diabetes, hypertension, and hyperlipidemia. As an essential source of high‐nutrition legumes, it is also an important source of dietary isoflavones.ObjectivesIn order to improve the preparation efficiency of natural plants, a rapid biological activity screening and preparation of xanthine oxidase inhibitors from C. arietinum L. was established.MethodsXanthine oxidase (XOD) inhibitors were rapidly screened using ultrafiltration liquid chromatography–mass spectrometry (UF‐LC–MS) based on receptor–ligand affinity. The change in XOD activity was evaluated by enzymatic reaction kinetics measurement. The potential bioactive compounds were verified through molecular docking. In addition, the biological activity of ligands screened was separated and purified by complex chromatography. The structures of the compounds were identified by nuclear magnetic resonance spectroscopy.ResultsThree active ingredients, namely daidzin, daidzein, calycosin with XOD binding affinities were identified and isolated from the raw plant materials via semi‐preparative high‐performance liquid chromatography (HPLC), 0–60 min, 5–50% B and countercurrent chromatography (CCC) (ethyl acetate/acetic acid/water [5:0.8:10, v/v/v]).ConclusionThis study will help to elucidate the mechanisms of action of natural plants of interest at the molecular level and could also provide more opportunities for the discovery and development of new nutritional value from other natural resources.
Scalar Field Evolution at Background and Perturbation Levels for a Broad Class of Potentials
Authors: Leon Genly , Chakraborty Saikat , Ghosh Sayantan , Solanki Raja , Sahoo P.K. , González Esteban 
Published: July 2023

AbstractIn this paper, a non‐interacting scalar field cosmology with an arbitrary potential using the f‐deviser method that relies on the differentiability properties of the potential is investigated. Using this alternative mathematical approach, a unified dynamical system analysis at a scalar field's background and perturbation levels with arbitrary potentials is presented. For illustration, a monomial and double exponential potential is considered. These two classes of potentials comprise the asymptotic behavior of several classes of scalar field potentials, and, therefore, they provide the skeleton for the typical behavior of arbitrary potentials. Moreover, the linear cosmological perturbations in the matterless case by considering three scalar perturbations: the evolution of the Bardeen potentials, the comoving curvature perturbation, the so‐called Sasaki‐Mukhanov variable, or the scalar field perturbation in uniform curvature gauge is analyzed. Finally, an exhaustive dynamical system analysis for each scalar perturbation is presented, including the evolution of Bardeen potentials in the presence of matter.
Therapeutic effect of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves on ischemic stroke via the microbiota–gut–brain axis
Authors: Wang Rongjin , Sun Yuzhen , Wang Meiyuan , Li Hanlin , Liu Shu , Liu Zhongying 
Published: July 2023

AbstractEleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves (ESL) are widely used to treat ischemic stroke (IS); however, the specific mechanism remains unclear. The microbiota–gut–brain axis plays a critical role in IS and has become a potential therapeutic target. This study aimed to reveal and verify the therapeutic effect of ESL on IS through the microbiota–gut–brain axis. Ultra‐high‐performance liquid chromatography coupled with mass spectrometry‐based untargeted/targeted metabolomics combined with 16S rRNA microbiota sequencing strategy were used to investigate the regulatory effect of ESL on the metabolism and intestinal microenvironment after IS. Lactobacillus reuteri and Clostridium butyricum were used to treat rats with IS to verify that elevated levels of probiotics are key factors in the therapeutic effect of ESL. The results showed that IS significantly altered the accumulation of 41 biomarkers, while ESL restored their concentrations back to normal. Moreover, ESL alleviated the dysbiosis of gut microbiota brought on by IS, by reducing the abundance of pathogens and increasing the abundance of probiotics (e.g., Lactobacillus reuteri and Clostridium butyricum); this could reduce post‐stroke injury, thereby having a certain protective effect on IS. This study reveals that ESL plays an important role in treating IS through the microbiota–gut–brain axis, maintaining metabolic homeostasis in vivo.