bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic risks from climate-related disruptions at ports
Authors: Verschuur Jasper , Koks Elco , Hall Jim 
Published: March 2023

Abstract
Disruptions to ports from climate extremes can have systemic impacts on global shipping, trade and supply chains. By combining analysis of climatic risks at 1320 ports worldwide with a global model of transport flows, we pinpoint systemic risks to maritime transport, trade and global supply-chain networks as a result of port downtime. We estimate a total of 81 USD billion of global trade and 122 USD billion of economic activity being at-risk on average annually.
MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression
Authors: Arbesman Joshua , Chelakkot Vipin Shankar , Thomas Kiara , Romigh Todd , Fong Andrew , Li Lin , Ronen Shira , Chen Shuyang , Funchain Pauline , Ni Ying 
Published: March 2023

Abstract
MC1R, a G-protein coupled receptor, triggers ultraviolet light-induced melanin synthesis and DNA repair in melanocytes and is implicated in the pathogenesis of melanoma. Although it is widely expressed in different tissue types, its function in non-cutaneous tissue is relatively unknown. Herein, we demonstrate that disruptive MC1R variants associated with melanomagenesis are less frequently found in patients with several cancers. Further exploration revealed that breast cancer tissue shows a significantly higher MC1R expression than normal breast tissue, and knocking down MC1R significantly reduced cell proliferation in vitro and in vivo. Mechanistically, MC1R signaling through the MC1R-cAMP-CREB/ATF-1 and MC1R-ERK-NFκB axes regulated cyclin D1 expression, modulating G1-S transition in breast cancer cells. Our results revealed a novel association between MC1R and breast cancer, which could be potentially targeted therapeutically. Moreover, our results suggest that MC1R-enhancing/activating therapies should be used cautiously, as they might be pro-tumorigenic in certain contexts.
Semiconducting Copper Oxide Nanostructure Material and Their Modified Electrode for Electrocatalytic Oxidation of Hydrazine and Glucose
Authors: M Alexander , Pandian Arjun , K Pandian 
Published: March 2023

Abstract
The semiconducting copper oxide (CuO) nanostructure material is synthesized by carbon sphere used as template. The copper nitrate Cu(NO3)2 used as precursor and it has converted into CuO material like a Kernel structure with diameter 350 nm. It is applied to modify the glassy carbon electrode (GCE) for electro catalytic property of glucose and hydrazine oxidation; it shows a fast response and exhibited higher electro catalyst electrocatalytic oxidation of hydrazine and glucose. The electro catalytic behavior and applications were carried out by cyclic voltammetry in 0.1 M NaOH solution. The synthesized CuO nanomaterials have been characterized by FT-IR spectrum, X-Ray Photoelectron Spectra (XPS), DRS-UV spectra, Field Emission Scanning Electron Microscopy (FESEM) and Energy Dispersive X-ray pattern (EDX).
Intrinsic Instability of Rhombohedral (Hf, Zr)O2 Phases and Endurance Crisis of Hf-based Ferroelectric Devices
Authors: Wei Jinchen , Xu Guanghua , Huang Menglin , Wu Yuning , Li Wenwu , Xiang Hongjun , Chen Shiyou 
Published: March 2023

Abstract
Since the experimental report of rhombohedral HfO2 and Hf0.5Zr0.5O2 (HZO) phases on La0.7Sr0.3MnO3 (LSMO) substrate, they have attracted intensive attention as a new type of Hf-based ferroelectrics. However, ferroelectric devices with good endurance based on the rhombohedral phases (r-phases) have not been successfully fabricated so far. We find by first-principles calculations that the rhombohedral R3m and R3 structures have imaginary phonon modes and negative formation energies of point defects (O vacancies or interstitials), showing obviously that the r-phases are intrinsically unstable. The instability originates from the easy transformation from rhombohedral structures to non-rhombohedral structures, which has negligible or even no energy barrier, no matter at the strain-free state or under the compressive epitaxial strain from LSMO substrate. Non-rhombohedral phases such as ferroelectric orthorhombic and paraelectric monoclinic P21/m phase can coexist even if r-phases can be fabricated, and the easy transformation to paraelectric P21/m phase can cause quick fatigue and endurance crisis of devices. The experimentally observed monoclinic phase in HZO films grown on LSMO substrate should be attributed to the P21/m structure, which has the lowest-energy structure on LSMO substrate but was misidentified as the well-known P21/c structure. These results reveal the microscopic origin of the difficulty in fabricating r-phase HZO devices and provide a map for guiding the device endurance optimization through controlling epitaxial strain and suppressing defect formation.
A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: Utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment.
Authors: Hashimoto Naohito , Suzuki Tomonari , Ishizawa Keisuke , Nobusawa Sumihito , Yokoo Hideaki , Nishikawa Ryo , Yasuda Masanori , Sasaki Atsushi 
Published: March 2023

Abstract
EPN-ZFTA is a rare brain tumor for which prognostic factors are unclear and there is currently no effective immunotherapy or chemotherapy. Therefore, the present study investigated its clinicopathological features, evaluated the utility of MTAP and p16 IHC as surrogate markers of CDKN2A alterations, and characterized immune cells and immunological molecules in the microenvironment of EPN-ZFTA. Thirty surgically removed brain tumors, including 10 EPN-ZFTA, were subjected to IHC. MLPA was performed to detect CDKN2A HD in 20 ependymal tumors, including EPN-ZFTA. The 5-year OS and PFS rates of EPN-ZFTA were 90 and 60%, respectively. CDKN2A HD was detected in 2 cases of EPN-ZFTA by MLPA. These cases were immunohistochemically negative for both MTAP and p16 and recurred earlier after surgery. PD-L1 was negative in all cases of EPN-ZFTA, whereas B7-H3 expression was observed in all cases. Regarding lymphocyte/macrophage markers, the expression of Iba-1 and CD204 was high and the number of infiltrating lymphocytes was small in EPN-ZFTA. Collectively, the present results indicate the potential of MTAP and p16 IHC as useful surrogate markers of CDKN2A HD in EPN-ZFTA, and tumor-associated macrophages, including the M2 type, may contribute to its microenvironment.
Investigating gaseous pollutants emitted from Saipa automotive group and surrounding roads into the atmosphere using the combination of the AERMOD dispersion model and the MOVES model
Authors: Naghdi Soudabe , Mirmohammadi Mohsen , Karimzadegan Hassan , Ghodoosi Jamal 
Published: March 2023

Abstract
Due to the different types of pollution they put out, putting automotive factories in cities can hurt the air quality in those cities. The aim of this study is to investigate the simultaneous effects of the Saipa automobile industry and two surrounding highways on air quality. This study used Mehrabad meteorological station data for 2019 along with emission rates and topographical data to model the gaseous pollutants released from automobile factories and linear sources using AERMOD software. Field measurements of NO2 pollution by passive adsorbents confirmed the accuracy of the results with a 0.99 correlation, and the same average of two communities of modele and observed concentration. The Lashkari highway has the maximum yearly NO2 concentration of 1209 parts per billion at 515326.80 and 3953279.17 meters, 23 times the NAAQS, The Lashkari freeway had the greatest CO concentration, 12.6 parts per million, at 515326.80 and 3953279.17 meters, 1.4 times the NAAQS. Highway passengers are exposed to NO2 and CO levels above the NAAQS, demonstrating the need for highway and traffic law reform.
Effects of chronic heat stress on kidney damage, apoptosis, inflammation and HSPs of Acipenser baerii
Authors: Yang Shiyong , Chen Qianyu , Zhang Jiajin , Yan Chaozhan , Zhang Chaoyang , Xu Zihan , Li Caiyi , Huang Xiaoli , Luo Wei , Wu Jiayun , Li Yunkun 
Published: March 2023

Abstract
Chronic heat stress caused by global warming can have serious implications for fish survival. The kidney plays a central role in many homeostatic functions, including water and electrolyte regulation, as well as acid-base balance. However, there is limited knowledge about the effect of heat stress on fish kidneys, especially in cold-water fish species. In this study, we investigated the effects of mild heat stress (24℃, M) and high heat stress (28℃, H) on A. baerii kidneys using histological observation, flow cytometry detection, and RT-qPCR. Our histological observations revealed that heat stress significantly caused infiltration of inflammatory cells in the kidney, especially at 28℃. The flow cytometry assay demonstrated a significant increase in the number of apoptotic cells after heat stress at 28°C compared to the control group at 20°C (P < 0.05). Meanwhile, the mRNA expression levels of inflammation factors (IL-1β and TNF-α) did not differ significantly. However, the mRNA expression levels of heat shock proteins (HSP70, HSP90, and GRP75) were increased in A. baerii. In summary, this study provides insight into the effect of heat stress on A. baerii kidneys and contributes to understanding the coping strategies of cold-water fish to chronic heat stress.
Preservation and Sustainability of Earthen Architecture. The Vernacular Ksar of Khanguet Sidi Nadji in Algerian Sahara as a Case Study
Authors: Zaghez Imen , Attoui Redha , Saou-Dufrêne Bernadette 
Published: March 2023

Abstract
Man has always built and lived in earthen architecture. These have many qualities according to the geographical areas, specificities even if the agglomerations developed from social backgrounds and techniques that can highlight cultural convergences and policies. Algeria has a vernacular architectural heritage of recognized value, specifically in Sahara oases. Khanguet Sidi Nadji is a vernacular ksar and a typical pre-Saharan oasis in a mountain area, built out of an incomparable landscape integration and plasticity. Nowadays, through obsolescence and abandonment of this heritage, Ksar Khanguet Sidi Nadji is threatened with disappearance. In view of its deteriorated conditions, came this research to document this rammed earthen architecture, and to propose a new sustainable horizon of earthen heritage preservation. The main purpose of this research is how to achieve a conservation protocol for Khanguet Sidi Nadji, taking account of technical and philosophical challenges encountered while applying the method of anastylosis in reconstructing the remains of the ksar using existing components. Our study shows that the proposed conservation protocol is feasible and perfectly fits the targeted region with regard to its challenges and specificities.
Perceptions of COVID-19 risks and protective actions: a qualitative study in six Sudanese communities
Authors: Abdelmagid Nada , Ahmed Salma A.E. , Nurelhuda Nazik , Zainalabdeen Israa , Ahmed Aljaile , Abdalla Omama , Dawd Ahmed , Eldirdiri Ahmed , Ibrahim Omnia , Ismail Drij , AbuKoura Rahaf , Gaafar Reem , Dahab Maysoon 
Published: March 2023

Abstract
Background
Risk communication is an essential strategy in outbreak response. Understanding perceptions of health risks and protective behaviours is critical for informing effective risk communication during outbreaks. This study aimed to explore Coronavirus disease (COVID-19) knowledge, risk perception and precautionary behaviours during the early weeks of the COVID-19 epidemic in Sudan.
Methods
In-depth telephone interviews were conducted with 59 adults from six of urban, rural and forcibly displaced communities in Sudan. Participants were from households with members at higher risk of severe COVID-19 outcomes. We analysed data using participatory group analysis followed by a thematic inductive and deductive analysis of interview transcripts. We used the Health Belief Model to analyse, present and discuss the findings.
Results
Most participants perceived a high susceptibility to COVID-19, especially among older people, due to novelty and transmission characteristics of the disease. However, a few were mainly concerned about the livelihood implications of the government’s response. Our respondents had good knowledge about COVID-19 although there were a few misconceptions. Most participants viewed COVID-19 as a highly infectious, dangerous and fatal disease. Most participants understood the benefits of protective measures and reported complying with hand hygiene. A few reported complying with social and physical distancing, including stay-at-home orders. Compliance was generally poorer among older adults. Many participants reported substantial financial and social barriers to compliance and resistance to compliance in their communities fuelled by COVID-19 denialism, rumours, misinformation, and poorly enforced government restrictions.
Conclusion
High levels of knowledge and a high perceived susceptibility and severity of disease were not enough to motivate high levels of compliance with the protective measures in the study communities. Financial and social obligations to protective measures, coupled with COVID-19 denialism and rumours, were significant barriers to compliance. Early risk communication interventions should promote contextually appropriate, high-impact, low-cost interventions and tackle emerging rumours and misinformation.
Physical Exercise and Major Depressive Disorder in Adults: Systematic Review and Meta-analysis
Authors: Bedoya Edison Andrés Pérez , López Luisa Fernanda Puerta , Galvis Daniel Alejandro López , Jaimes Diego Alejandro Rojas , Moreira Osvaldo Costa 
Published: March 2023

Abstract
Background
The objective was to identify the benefits and harms of different physical exercise modalities in the symptomatology of major depressive disorder in adults without usual treatment.
Methods
We conducted a systematic review and meta-analysis of randomized controlled trials. Medline (via Ovid), Cochrane Central Register of Controlled Trials (CENTRAL), Embase, PsycInfo, Web of Science, Clinical Trials repository, gray literature, and manual search were searched from inception to November 2022 for relevant studies without language restriction. The following inclusion criteria were used for studies to determine their eligibility: randomized controlled trials (RCTs) in adults diagnosed with major depressive disorder who did not consume antidepressant medication or attended psychological therapy, with or without the presence of chronic communicable or non-communicable diseases, that compared physical exercise modalities with usual therapy, body-mind exercise or did not exercise. We excluded randomized controlled trials in development with pregnant women and adults with other mental health disorders such as bipolar disorder and anxiety. The risk of bias and quality of evidence were assessed using the Cochrane Risk of Bias II Tool and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE), respectively. The main outcome was depressive symptoms measured using validated depression scales after the intervention.
Results
The nine RCTs included 678 adults (211 men 31.12% and 467 women 68.88%) between 20 and 72 years old. The pooled standardized mean difference (SMD) of the 7 trials (12 interventions), calculated using the random effects model, was − 0.27 (95% CI [-0.58, 0.04) P = 0.09, indicating a small clinical effect in favor of exercise on the instruments scores that assess depressive symptoms, I2 = 76%. Sensitivity analyzes showed a moderate effect size, compared to primary outcomes, in favor of physical exercise: − 0.58 [-1.15, -0.01]. They even showed statistical significance: (P = 0.05); I² = 85%. Subgroup analyzes demonstrated that the intervention (i.e., < 12 weeks duration, frequency 5 per 150 minutes per week, at high intensity and with supervision) and characteristics (i.e., less than 50 years of age, overweight and obese, and diagnosis of depression) could influence the overall effect of treatment.
Discussion
We found low- to very low-quality evidence supporting the effect of physical exercise, compared with usual therapy, body mind exercise or doing nothing, on symptoms of major depressive disorder. Physical exercise is safe, although it produces adverse events that can be easily controlled. We downgraded the certainty of the evidence due to methodological limitations, inconsistency and imprecision. These are preliminary results, well-designed and reported randomized controlled trials are required.
A SEIAR epidemic model for Covid-19 with migration and stochastic transmission
Authors: Mohammed Salman , Sahoo Prativa , Mohapatra Anushaya , Mohanty Sanjay Kumar 
Published: March 2023

Abstract
In the case of a highly infectious disease like covid-19, understanding the role of population migration is important and challenging. In this research, we study the global dynamics of a covid-19 epidemic model, which incorporates population migration and stochastic rate of transmission. It is shown that in both deterministic and stochastic environments, the models are globally Lyapunov stable near the disease-free equilibrium point, which is determined by a threshold parameter. More ever, the effect of migration on Covid-19 is analyzed, and it has been found that the number of infections as well as the peak value of the infection curve, is more when there is more population migrating, and the results are supported by numerical illustrations with their epidemiological relevance. The disease-free equilibrium of the associated time delay model is linearly asymptotically stable, and the endemic equilibrium has more bifurcation for higher values of the time delay parameter.
2000 MSC: 92B10
Cyberbullying on YouTube social media: Ria Ricis's feedback on haters
Authors: Diyanti Diyanti , Mazaya Vyki 
Published: March 2023

Interactive communication in virtual space enables free and uncontrolled communication. This study aims to know the communication of Ria Ricis and the netizen and her feedback on haters. Ria Ricis is an influencer who often gets a negative response the netizen on her social media contents. This study will look at Ria Ricis feedback communication patterns on YouTube with Wilbur Schramm's theory. The data source was based on the haters' comments on a video "Ricis reaction in reading hate comments on Tiktok…Wkwk" uploaded by RICIS TV YouTube channel. The data analysis technique used data reduction, display, and conclusion. The result showed that the communication process started from some Ria Ricis posts on a TikTok account get many negative comments from the netizen. Then, there was a lot of pressure from her fans. So, she then created a YouTube video as the Ria Ricis's positive feedback for the haters. A positive response to the haters is given to minimize the occurrence of an unhealthy communication atmosphere and to reduce endless communication conflicts. The results of this study contribute to strengthening the existence of Islamic communication principles which can become a moral basis for communication activities on social media. ***Komunikasi interaktif di ruang maya memungkinkan komunikasi yang bebas dan tidak terkendali. Studi ini bertujuan untuk mengetahui komunikasi Ria Ricis dan netizen serta tanggapannya terhadap haters. Ria Ricis merupakan salah satu influencer yang sering mendapatkan respon negatif dari netizen pada konten media sosialnya. Studi ini akan melihat pola komunikasi umpan balik Ria Ricis di YouTube dengan teori Wilbur Schramm. Sumber datanya berdasarkan komentar para haters pada video “Reaksi Ricis membaca komentar kebencian di Tiktok...Wkwk” yang diunggah kanal YouTube RICIS TV. Teknik analisis data menggunakan reduksi data, display data, dan penarikan kesimpulan. Hasil kajian menunjukkan bahwa proses komunikasi yang dimulai dari beberapa postingan Ria Ricis di akun TikTok mendapatkan banyak komentar negatif dari netizen. Kemudian, ada banyak tekanan dari para penggemarnya sehingga ia lantas membuat video YouTube sebagai tanggapan positif Ria Ricis terhadap para haters. Tanggapan positif terhadap para pembenci diberikan untuk meminimalisir terjadinya suasana komunikasi yang tidak sehat dan untuk meredam konflik komunikasi yang tidak berkesudahan. Hasil studi ini berkontribusi bagi penguatan eksistensi prinsip komunikasi Islam yang dapat menjadi basis moral bagi kegiatan berkomunikasi di media sosial.
Traditionalist salafi’s involvement in the religious moderation da’wah
Authors: Farooq Abdullah Hafiz Muhammad , Hakim Lukmanul , Syahidan M. 
Published: March 2023

Traditionalist Salafi groups differ from political and jihadist salafi groups. Traditionalist Salafi chose a moderate path in their preaching. This article aims to analyze the moderate path of Salafi Rodja in Indonesia. Using a qualitative method where data is collected through observation and reading the community's official website and interviewing key informants, we argue that Rodja as a traditionalist salafi in Indonesia develops a moderate way of preaching by applying two approaches. First, contextualizing the understanding of jihad by rejecting violence in the name of Islamic jihad. Second, engage in social activities by providing educational services and moral and material assistance to people in need. Both of these approaches show the humanization of salafi teachings which are usually associated with extremism. This fact shows that Indonesian traditionalist Salafi seeks to emphasize moderate and humanist religious ways in their preaching. However, the tendency to moderate the way (manhaj) of da'wah cannot be separated from its position as a breakaway among mainstream moderate Islamic groups (Nahdlatul Ulama and Muhammadiyah), in addition to the government's efforts to eradicate extremist movements. This study contributes to the strengthening of moderate da'wah discourse among splinter groups***Kelompok Salafi tradisionalis berbeda dengan kelompok Salafi politik dan jihadis. Salafi tradisionalis memilih jalan moderate dalam dakwahnya. Artikel ini bertujuan untuk menganalisis jalur moderat Salafi Rodja di Indonesia. Dengan menggunakan metode kualitatif di mana data dikumpulkan melalui observasi dan membaca website resmi komunitas serta mewawancarai informan kunci, kami berpendapat bahwa Rodja sebagai salafi tradisionalis di Indonesia mengembangkan cara dakwah moderat dengan menerapkan dua pendekatan. Pertama, mengkontekstualisasikan pemahaman jihad dengan menolak kekerasan atas nama jihad Islam. Kedua, terlibat dalam kegiatan sosial dengan menyediakan layanan pendidikan dan bantuan moril dan material kepada masyarakat yang membutuhkan. Kedua pendekatan ini menunjukkan humanisasi ajaran salafi yang biasanya sering diasosiasikan dengan ekstremisme. Fakta ini menunjukkan bahwa Salafi tradisionalis Indonesia berusaha untuk menekankan cara-cara keagamaan yang moderat dan humanis dalam dakwahnya. Namun, kecenderungan untuk memoderasi cara (manhaj) dakwah tidak lepas dari posisinya sebagai sempalan di antara kelompok arus utama Islam moderat (Nahdlatul Ulama dan Muhammadiyah), di samping upaya pemerintah memberantas gerakan ekstremis. Studi ini memberikan kontribusi bagi penguatan diskursus dakwah moderat dalam kalangan kelompok sempalan.