bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive evaluation of immune dysregulation and altered cytotoxic markers in secondary hemophagocytic lymphohistiocytosis (sHLH)
Authors: Wang Yun , Yuan Xu , Wang Ting , Wei Wei , Wu Shiji , hou hongyan 
Published: July 2023

Abstract
Background
Host immune dysfunction plays a crucial role in the onset, progression, and outcome of hemophagocytic lymphohistiocytosis (HLH). This study aimed to comprehensively evaluate the peripheral immune profiles in patients with newly diagnosed secondary hemophagocytic lymphohistiocytosis (sHLH), and explore their predictive value for patient prognosis.
Methods
A total of 77 patients with sHLH were enrolled in this study, with 31 of them experiencing mortality. Flow cytometry was used to assess the percentages, absolute numbers, and phenotypes of lymphocyte subsets. Simultaneously, cytokine levels and routine laboratory indicators were also collected.
Results
In patients with sHLH, the percentages of CD3 + T cells, CD4 + T cells, and NK cells were found to be decreased, while the percentages of CD8 + T cells and B cells were increased compared to healthy controls. Similarly, when compared to disease controls (DCs), the percentages of CD3 + T cells and CD4 + T cells were decreased, while the percentages of NK cells were increased. Furthermore, the absolute numbers of lymphocyte subsets were significantly impaired in sHLH patients. Specifically, a notable decreased in EMRA CD8 + T cells were observed. Additionally, there was a significant increase in the proportion of plasma cells within the B cell population. We further investigated the prognostic value of immune indicators in sHLH. Kaplan-Meier survival analysis revealed that lower levels of CD3 + T cells, higher levels of APTT and IL-6 were associated with a poor prognosis in sHLH patients.
Conclusions
The lymphocyte subsets in the sHLH group exhibited dysregulation, with significant impairments observed in the absolute numbers of various lymphocyte subsets. Notably, CD3 + T cells and IL-6 were identified as critical markers for predicting prognosis and identifying potential treatment targets in HLH.
Nanofluid Assisted-Chemical Oil Recovery Process at High Temperature and High Salinity Conditions: Nanofluid Stability, Interfacial Tension, Contact Angle, Microscale Experimental Investigation
Authors: Hashemi Mohammad , Tamsilian Yousef , Kord Shahin 
Published: July 2023

Abstract
One of the most important aspects to use the nanofluid flow through the oil recovery process is physical and chemical constraints at high salinity and temperature, harsh conditions, leading to the instability and further problems. In this study, the stability of various nanoparticles, Al2O3, SiO2, ZrO2, TiO2, Fe2O3, nanoclay, and ZnO, were examined upon the concentration (0.01 to 3 wt%), temperature (ambient and 75℃), salinity (20,000 to 80,000 ppm), pH (2 to 12), and stabilizers of polyethylene glycol, polyvinylpyrrolidone, guar gum, Triton X-100, sodium dodecyl sulfate, cetrimonium bromide. Then, the most stable nanofluid was nominated to investigate the oil recovery mechanisms by performing interfacial tension (IFT), wettability alteration, and micromodel flooding analyses. Zinc oxide and silicon dioxide nanofluids were maintained their stability at the harsh conditions and guar gum showed a good performance in stabilizing nanofluids, compared to other nanofluids agglomerated. According to the results of the IFT reduction upon the nanofluid and reservoir crude oil (1.64 mN/m), wettability alteration of carbonate cores (113.68 degree) and micromodel experiments (additional recovery of 32.23% and 6.27% in the secondary and tertiary flooding, respectively) all compared to the seawater, the ZnO nanofluid stabilized by guar gum was an excellent candidate to use in the oil recovery projects.
Soil bio-solarization and Trichoderma asperellum suppress black root rot disease and increase strawberry yield
Authors: Abd-El-Kareem Farid , Saied Nehal M. , Elshahawy Ibrahim E. , Abd-Elgawad Mahfouz 
Published: July 2023

Abstract
Trichoderma asperellum applied as pellets, disks, or spore suspension against the causal agents of strawberry-black root rot disease represented by three fungal species was tested. The pellets/disks could significantly reduce the growth area of the pathogenic fungi Rhizoctonia solani, Fusarium solani, and Macrophomina phaseolina in vitro. Solarization via mulching soil with transparent polyethylene sheets could affect these pathogens. It reduced the counts of the fungi buried in cloth bags at 1–10 cm of soil surface by 70, 65, and 65% for R. solani, F. solani, and M. phaseolina, respectively relative to unmulched soil. Yet, the more depths of bags in soil, the less the mulching affects the three pathogens. In two field experiments, the disease incidence and severity were more reduced when T. asperellum pellets/suspension was integrated with bio-solarization (mulching soon after bio-fumigation with Al-Abour Compost®)) than any single treatment. The highest reductions obtained by T. asperellum pellets combined with bio-solarization averaged 75 and 73.8%, respectively. Bio-solarization with Actamyl affected the disease incidence/severity to a lesser extent. All tested treatments significantly boosted yield of strawberry plants. Strawberry yield and activities of the pathogenesis-related proteins peroxidase and chitinase showed favorable responses almost parallel to the extent of reduction in the disease incidence and severity caused by all treatments. The highest yield increase achieved via combining T. asperellum pellets with bio-solarization was 160.8%. Our results support hypothetical biocontrol potential that T. asperellum and bio-solarization together with adequate phytosanitary measures can reliably control strawberry-black root rot disease and enhance strawberry yield.
Prediction of lymph node metastasis in patients with papillary thyroid cancer based on radiomics analysis and intraoperative frozen section: a retrospective study
Authors: Lv Xin , Lu Jing-Jing , Hou Yi-Ru , Song Si-Meng , Hu Yan-Jun , Yan Yan , Yu Tao , Ye Dong-Man 
Published: July 2023

Abstract

Purpose To evaluate the diagnostic efficiency among clinical model, radiomics model and nomogram that combined radiomics features and frozen section (FS) analysis for the prediction of lymph node (LN) metastasis for the patients with papillary thyroid cancer (PTC). Methods A total of 208 patients with PTC were retrospectively enrolled. The patients were divided into two groups randomly for training groups and validation groups. The Least absolute shrinkage and selection operator (LASSO) regression were used for the selection of radiomics feature extracted from ultrasound (US) images. Univariate and multivariate logistic analysis were used to select predictors including clinical characteristics and FS associated with the status of LN. The clinical model, radiomics model and nomogram were subsequently established. Results Multivariate analysis indicated that age, size group, Adler grade, ACR score and the psammoma body group were independent predictors to predict lymph node metastasis (LNM). The results showed that in the training group, nomogram had better performance than clinical model (P > 0.05) and radiomics model (P < 0.05). In the validation group, the results were similar to the training group, nomogram had a little higher diagnostic efficiency than clinical model (P > 0.05) and radiomic model (P > 0.05). Both in the training and validation group, nomogram had minor non-significant improvements in AUC compared to clinical model and significant improvements compared to radiomic model, however, the sensitivity of nomogram was a little higher. Conclusion We proposed that the nomogram combined the radiomics features and FS had the promise to create a substantial biomarker for predicting LNM of patients with PTC.
Undernutrition and Associated Factors Among Young Patients on Anti-retroviral Therapy in North Shoa, Oromia, Etiopia,2022. A Facility- Based Cross-sectional Study
Authors: Nigussie Fikadu , Sahlu Degemu , Gizaw Seifu 
Published: July 2023

Abstract

Background Undernutrition and the Human Immunodeficiency Virus (HIV) are related in a complex and harmful way and are both exceedingly prevalent throughout the world, particularly in sub-Saharan Africa. In Ethiopia, the prevalence of undernutrition ranged from 12.3–43% and the prevalence of stunting and thinness among HIV-infected adolescents were 39%) and 14% respectively. There is no study among young patients living with Human Immunodeficiency Virus and ART. Therefore, this study aims to assess the prevalence of undernutrition and its associated factor among young infected with HIV and following ART clinics at the north Shoa health facilities in Oromia, Ethiopia. Methods A facility-based cross-sectional study was conducted. A probability-proportional sampling method was used to select 387 participants and pretested, interview-administered questionnaires were used to collect the data. The information was entered into EpiData and analyzed with SPSS. A 95% confidence interval and a P-value less than 0.05 were used to identify predictor variables, and an adjusted odds ratio (AOR) was used to assess the strength of the association. Result The prevalence of stunting and thinness in the study was 37% (95% CI: 32.0,41.9) and 13.4% (95%, CI:10.3, 16.9) respectively. Being male (AOR 1.5, 95%CI: 1.0,2.4), educational level of caregiver(AOR 7.8, 95%CI: 3.5, 17.2), and having a family income ≤ 1500 ETB (AOR 7.8,95%CI:3.5,17.2) were significantly associated with stunting while being male (AOR = 2.59,95% CI: 1.25,5.40), nutritional counseling (AOR 4.05,95% CI:1.64,10.02), Skipping meal (AOR 4.97,95%CI:2.08,11.9) and educational level of caregiver (AOR 4.18,95% CI:1.82,9.60) were significantly associated with thinness. Conclusion The prevalence of stunting and thinness among HIV-infected adolescents and youth in the study area was consistent with EDHS and higher than the EDHS report respectively. Sex, skipping a meal, nutritional counseling, and family size were significantly associated with thinness and Sex, educational level of the caregiver, and family income was significantly associated with stunting.
In Search of Conceptual Clarity about the Structure of Psychopathic Traits in Children: A Network-based Proposal
Authors: López-Romero Laura , Andershed Henrik , Romero Estrella , Cervin Matti 
Published: July 2023

Abstract
Psychopathic traits in childhood have been revealed as potential identifiers of risk, being predictive of later forms of behavioral maladjustment. Yet, it is still under debate how psychopathic traits in children should be best conceptualized and which dimensions to use for construct definition and prediction. The present study aims to examine the structure of psychopathic traits in childhood, and its predictive value, by using a combination of traditional factor analysis and more recent network-based methods. Data on psychopathic traits, as measured by the Child Problematic Traits Inventory (CPTI), were collected in a large sample of children (n = 2,454; 48.2% girls), aged 3 to 6 at the onset of the study (Mage = 4.26; SD = 0.91), who were followed-up one and two years later using parent- and teacher-reports. Results showed that psychopathic traits measured via CPTI are best conceptualized as five latent factors encompassing grandiosity, deceitfulness, callousness, impulsivityand need of stimulation, a result that converged across informants and time. Callousness and grandiosity emerged as central traits using network analysis of parent-reports, while deceitfulness was most central using teacher-reports. Finally, callousness, impulsivity and deceitfulness emerged as the best predictors of concurrent, prospective and stable conduct problems. These results provide a refined structure of psychopathic traits in children that better accounts for the core elements of the construct. Additional theoretical and practical implications will be discussed in terms of assessment, diagnostic classification and tailored prevention/intervention.
Ferroptosis-related lncRNAs guiding osteosarcoma prognosis and immune microenvironment
Authors: Yang Mingyi , Su Yani , Xu Ke , Zheng Haishi , Yuan Qilings , Cai Yongsong , Aihaiti Yirixiati , Xu Peng 
Published: July 2023

Abstract
Objective: To study the ferroptosis-related LncRNAs (FRLncs) that can guide the prognosis and immune microenvironment of osteosarcoma (OS), and provide a basis for clinical decision-making of OS.
Methods: 86 OS transcriptome data and clinical data were downloaded from The Cancer Genome Atlas (TCGA) database, GSE19276 data set was downloaded from Gene Expression Omnibus (GEO) database, and ferroptosis-related genes (FRGs) list were obtained from FerrDb database. Differential FRGs related to OS were obtained by combined analysis of 86 OS transcriptome data and GSE19276 data set, and FRLncs related to OS were obtained by co-expression analysis. Univariate COX regression analysis and Lasso Cox regression analysis were used to construct the OS risk prognostic model of FRLncs. Further risk curve analysis, survival analysis, (Receiver operating characteristic curve, ROC) curve analysis and independent prognosis analysis were performed. Model validation of clinical groupings was performed to observe whether risk-prognostic models were applicable to patients in different clinical groups. Single sample Gene Set Enrichment Analysis (ssGSEA) explored differential immune cells and immune functions in risk prognostic models. Immune checkpoint differential analysis obtained immune checkpoint-related genes associated with OS prognosis.
Results: Finally, 13 FRLncs that could guide OS prognosis and immune microenvironment were obtained, including 5 high-risk FRLncs (AP000757.1, AL035530.2, AC006160.1, PRR34-AS1 and LINC01719) and 8 low-risk FRLncs (AC090559.1, AC100847.1, MIS18A-AS1, ITCH-IT1, AL031722.1, AC027575.2, AC104561.1 and NBR2). 8 types of immune cells (B cells, macrophages, neutrophils, natural killer (NK) cells, plasmacytoid dendritic cells (pDCs), helper T cells, tumor infiltrating lymphocytes (TIL) and regulatory T cells (Treg)) and 4 immune functions (APC-co-stimulation, check-point, cytolytic-activity and T cell- co-inhibition) were down-regulated in the high-risk group. In addition, we also obtained 17 immune checkpoint-related genes associated with OS prognosis, of which LGALS9, BTLA and TNFSF15 had extremely high statistical significance(P＜0.001).
Conclusion: The FRLncs that can guide OS prognosis and immune microenvironment and the immune checkpoint-related genes associated with OS prognosis found in this study provide a theoretical basis for OS survival research and clinical decision-making.
Numerical modeling of the asymmetric hot plate method considering lateral convective losses
Authors: Dia Mohameth , DIALLO Mamadou , Faye Mactar , Sambou Vincent 
Published: July 2023

Abstract
In this study, a numerical model of the asymmetric hot plate method was developed to determine the thermal properties of materials. The proposed model considers the convective heat loss around the device. First, a numerical calculation code is developed to determine the temperature evolution at the measurement points. This calculation code is then used to perform a reduced sensitivity study on various parameters. The Levenberg-Marquardt algorithm was used to identify the thermal properties of different materials from the thermogram. The impacts of the convection coefficient h and insulation thickness on the calculation of the estimates were studied. Finally, an experimental study was conducted using several materials. The thermal properties were compared with experimental results obtained using other measurement methods. A satisfactory agreement was obtained.
An approach to analyse the error performance of linear receivers for Multi-User Massive MIMO communication systems under Imperfect CSI
Authors: Hosany Mussawir , Rajkumarsingh Bhimsen , FOWDUR Pawan 
Published: July 2023

Abstract
The massive MIMO communication system for cellular networks has shown excellent performance in terms of high spectral and energy efficiencies in recent years. This achievement has been due to the assiduous research undertaken in terms of formulating mathematical expressions to compute these efficiencies. The purpose of this work is to find a generalized approach to compute the error rates of a user terminal connected to a linear receiver of a Massive MIMO system. In line with the objectives set for present and future cellular networks to achieve ultra-reliable communication systems the issue of finding bit error rates required per user terminal is evaluated for a range of BS antennas is addressed in this paper. The approach employed to tackle this issue is to consider three practical linear receivers such as Maximum Ratio Combining (MRC), Zero-Forcing (ZF), Minimum Mean Square Error (MMSE) altogether with an uncorrelated Rayleigh fading environment in the case of imperfect Channel State Information (CSI). Based on solid mathematical foundations, the approach to find the Bit Error Rate (BER) closed-form expressions which are simple to evaluate and have not been reported in literatures yet, are derived for MPSK and MQAM modulation techniques. We verified the validity of our analysis by simulating all mathematical formulations using Matlab R2018 and we showed interesting results such as the number of BS antennas required to achieve the desired BER for a specific uplink receiver and modulation scheme. The mathematical analysis presented in this work can be applied to future cellular systems to compute the distribution of error rates for a user with a given number of BS antennas and modulation scheme. Moreover, Machine Learning algorithms could be applied to the analysis presented to predict the bit error rates for any user terminal in the cellular network.
WITHDRAWN: Biosynthesis of silver nanoparticles using Actinidia deliciosa peels extract: Optimization, characterization, and catalytic activity for methylene blue dye degradation
Authors: Agha Maya Kassem , Maatouk Batoul , Mhanna Rami , El-Dakdouki Mohammad 
Published: July 2023

Abstract
The green synthesis of silver nanoparticles (AgNPs) was successfully achieved using Actinidia deliciosa (kiwifruit) peels aqueous extract as a bioreducing agent under optimized synthesis conditions. TEM and SEM images revealed quasi-spherical monodisperse nanoparticles 25 nm in diameter. The hydrodynamic diameter of the nanoparticles was 106 nm as determined by DLS, and the highly negative ζ-potential (-34 mV) supported its superior colloidal stability. EDX confirmed that silver is a major constituent of the nanoparticles. XRD diffractograms confirmed the crystallinity of the nanoparticles and its face-centered cubic (fcc) lattice structure. The functional groups in the plant’s phytochemicals facilitating the reduction of Ag+ ions and stabilizing the formed AgNPs were identified using FTIR. Phytochemical analysis by colorimetric assays revealed that the kiwifruit peel extract was rich in phenolic compounds. The biosynthesized AgNPs induced instant discoloration of the methylene blue dye with 1.6 mg of nanoparticles used. The degradation reaction followed second order kinetics.
Efficacy of probiotics or synbiotics in critically ill patients: A systematic review and meta- analysis
Authors: Lou Jiaqi , Cui Shengyong , Huang Neng , Jin Guoying , Chen Cui , Fan Youfen , Zhang Chun , Li Jiliang 
Published: July 2023

Abstract
Background
This latest systematic review and meta-analysis aim to examine the effects of probiotic and synbiotic supplementation in critically ill patients.
Methods
Relevant articles were retrieved from PubMed, Embase, the Cochrane Database, and the Web of Science. The primary output measure was the incident of vendor associated pneumonia, and the secondary outputs were diarra, Clostridium diffusion infection (CDI), incident of sepsis, incident of hospital acquired pneumonia, incident of any infection, duration of mechanical exploitation, in hospital morality, length of hospital stay, ICU morality rate, And length of ICU stay. Data were pooled and expressed as relative risk (RR) and standardized mean difference (SMD) with a 95% confidence interval (CI).
Results
Third three studies were included in this systematic review and meta-analysis, with 4065 patients who received probiotics or synbiotics (treatment group) and 3821 patients who received standard care or placebo (control group). The pooled data from all included studies demonstrated that the treatment group has significantly reduced incidence of vessel associated pneumonia (VAP) (RR = 0.80; 95% CI: 0.67–0.96; p = 0.021, I2 = 52.5%) and sepsis (RR = 0.97; 95% CI: 0.66–1.42; p = 0.032, I2 = 54.4%), As well as significantly increased duration of mechanical exploitation (SMD=-0.47; 95% CI: -0.74–0.20, p = 0.012, I2 = 63.4%), length of hospital stay (SMD=-0.33; 95% CI: -0.57–0.08, p = 0.000, I2 = 74.2%), ICU mobility (RR = 0.95; 95% CI: 0.71–1.27; p = 0.004, I2 = 62.8%), And length of ICU stay [SMD=-0.29; 95% CI: -0.58-0.01; p = 0.000, I2 = 82.3%)] than the control group There were no significant differences in diarra, CDI, incidence of hospital acquired pneumonia, and in hospital morality between the two groups.
Conclusion
Our meta-analysis showed that probiotic and synbiotic supplements are beneficial for critically ill patients as they significantly reduce the incidence of vendor associated pneumonia and sepsis, as well as the duration of mechanical exploitation, length of hospital stay, length of ICU stay, and ICU morality How, this intervention has minimal impact on diarra, CDI, incidence of hospital acquired pneumonia, and in hospital morality in critically ill patients.
Exploring transcription processes when children with and without reading and writing difﬁculties produce written text using speech recognition
Authors: Kraft Sanna , Rønneberg Vibeke , Rack John , Thurfjell Fredrik , Wengelin Åsa 
Published: July 2023

The aim of this study was to investigate composition and error-correction processes, and their relationship with production rate, in children, age 10-12, with and without reading and writing difficulties using speech-to-text (STT) to write expository texts in Swedish. Measures of individual abilities: working memory, spelling ability and decoding ability, and the ability to interact with the STT tool under optimal conditions (STT success rate) were collected.
For both those with and without difficulties, neither working memory, nor spelling or decoding ability predicted burst length nor accuracy. Only a child’s STT success rate did predict accuracy during text composition. Further, none of the individual abilities predicted choice of error-correction modality (keyboard or STT) or error correction functionality. This indicates that the children’s behavior were independent of these abilities.
Furthermore, production rate was significantly predicted by both burst length and accuracy, and by working memory, but not by error-correction behaviour, nor by spelling or decoding ability. This indicates that composing text using STT is a cognitively complex process placing heavy demands on working memory. Dictating more than one word at a time and combining STT and keyboard use were identified as two useful strategies that can be taught in STT instruction.