bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREdiction and Diagnosis using Imaging and Clinical biomarkers Trial in Traumatic Brain Injury (PREDICT-TBI) study protocol: an observational, prospective, multicentre cohort study for the prediction of outcome in moderate-to-severe TBI
Authors: Nasrallah Fatima , Bellapart Judith , Walsham James , Jacobson Esther , To Xuan Vinh , Manzanero Silvia , Brown Nathan , Meyer Jason , Stuart Janine , Evans Tracey , Chandra Shekhar S , Ross Jason , Campbell Lewis , Senthuran Siva , Newcombe Virginia , McCullough James , Fleming Jennifer , Pollard Clifford , Reade Michael 
Published: April 2023

IntroductionTraumatic brain injury (TBI) is a heterogeneous condition with a broad spectrum of injury severity, pathophysiological processes and variable outcomes. For moderate-to-severe TBI survivors, recovery is often protracted and outcomes can range from total dependence to full recovery. Despite advances in medical treatment options, prognosis remains largely unchanged. The objective of this study is to develop a machine learning predictive model for neurological outcomes at 6 months in patients with a moderate-to-severe TBI, incorporating longitudinal clinical, multimodal neuroimaging and blood biomarker predictor variables.Methods and analysisA prospective, observational, cohort study will enrol 300 patients with moderate-to-severe TBI from seven Australian hospitals over 3 years. Candidate predictors including demographic and general health variables, and longitudinal clinical, neuroimaging (CT and MRI), blood biomarker and patient-reported outcome measures will be collected at multiple time points within the acute phase of injury. The predictor variables will populate novel machine learning models to predict the Glasgow Outcome Scale Extended 6 months after injury. The study will also expand on current prognostic models by including novel blood biomarkers (circulating cell-free DNA), and the results of quantitative neuroimaging such as Quantitative Susceptibility Mapping and Dynamic Contrast Enhanced MRI as predictor variables.Ethics and disseminationEthical approval has been obtained by the Royal Brisbane and Women’s Hospital Human Research Ethics Committee, Queensland. Participants or their substitute decision-maker/s will receive oral and written information about the study before providing written informed consent. Study findings will be disseminated by peer-review publications and presented at national and international conferences and clinical networks.Trial registration numberACTRN12620001360909.
Clinicians’ perspectives on planned interventions tested in the Otago MASTER feasibility trial: an implementation-based process evaluation study
Authors: Ribeiro Daniel C , Wilkinson Amanda , Voney Melanie , Sole Gisela , Lamb Sarah E , Abbott J Haxby 
Published: April 2023

ObjectivesThis study reports a process evaluation of the Otago MASTER (MAnagement of Subacromial disorders of The shouldER) feasibility trial. This mixed-methods, process evaluation study was conducted parallel to the Otago MASTER feasibility trial. Our aims were to investigate: (1) supervised treatment fidelity of the interventions and (2) clinicians’ perceptions of the trial interventions through a focus group.DesignNested process evaluation study using a mixed-methods approach.SettingOutpatient clinic.ParticipantsFive clinicians (two men, three women) aged 47–67 years, with clinical experience of 18–43 years and a minimum of postgraduate certificate training, were involved with the delivery of interventions within the feasibility trial. We assessed treatment fidelity for supervised exercises through audit of clinicians’ records and compared those with the planned protocol. Clinicians took part in a focus group that lasted for approximately 1 hour. The focus group was transcribed verbatim and focus group discussion was analysed thematically using an iterative approach.ResultsThe fidelity score for the tailored exercise and manual therapy intervention was 80.3% (SD: 7.7%) and for the standardised exercise intervention, 82.9% (SD: 5.9%). Clinicians’ perspectives about the trial and planned intervention were summarised by one main theme ‘conflict experienced between individual clinical practice and the intervention protocol’, which was supported by three subthemes: (1) programme strengths and weaknesses; (2) design-related and administrative barriers; and (3) training-related barriers.ConclusionThis mixed-methods study assessed supervised treatment fidelity of interventions and clinicians’ perceptions on planned interventions tested in the Otago MASTER feasibility trial. Overall, treatment fidelity was acceptable for both intervention arms; however, we observed low fidelity for certain domains within the tailored exercise and manual therapy intervention. Our focus group identified several barriers clinicians faced while delivering the planned interventions. Those findings are of relevance for planning the definite trial and for researchers conducting feasibility trials.Trial registration numberANZCTR: 12617001405303.
Does doctors’ personality differ from those of patients, the highly educated and other caring professions? An observational study using two nationally representative Australian surveys
Authors: Ammi Mehdi , Fooken Jonas , Klein Jill , Scott Anthony 
Published: April 2023

ObjectivesPersonality differences between doctors and patients can affect treatment outcomes. We examine these trait disparities, as well as differences across medical specialities.DesignRetrospective, observational statistical analysis of secondary data.SettingData from two data sets that are nationally representative of doctors and the general population in Australia.ParticipantsWe include 23 358 individuals from a representative survey of the general Australian population (with subgroups of 18 705 patients, 1261 highly educated individuals and 5814 working in caring professions) as well as 19 351 doctors from a representative survey of doctors in Australia (with subgroups of 5844 general practitioners, 1776 person-oriented specialists and 3245 technique-oriented specialists).Main outcome measuresBig Five personality traits and locus of control. Measures are standardised by gender, age and being born overseas and weighted to be representative of their population.ResultsDoctors are significantly more agreeable (a: standardised score −0.12, 95% CIs −0.18 to −0.06), conscientious (c: −0.27 to –0.33 to −0.20), extroverted (e: 0.11, 0.04 to 0.17) and neurotic (n: 0.14, CI 0.08 to 0.20) than the general population (a: −0.38 to –0.42 to −0.34, c: −0.96 to –1.00 to −0.91, e: −0.22 to –0.26 to −0.19, n: −1.01 to –1.03 to −0.98) or patients (a: −0.77 to –0.85 to −0.69, c: −1.27 to –1.36 to −1.19, e: −0.24 to –0.31 to −0.18, n: −0.71 to –0.76 to −0.66). Patients (−0.03 to –0.10 to 0.05) are more open than doctors (−0.30 to –0.36 to −0.23). Doctors have a significantly more external locus of control (0.06, 0.00 to 0.13) than the general population (−0.10 to –0.13 to −0.06) but do not differ from patients (−0.04 to –0.11 to 0.03). There are minor differences in personality traits among doctors with different specialities.ConclusionsSeveral personality traits differ between doctors, the population and patients. Awareness about differences can improve doctor–patient communication and allow patients to understand and comply with treatment recommendations.
Population-based assessment of cardiovascular complications of rheumatic heart disease in Fiji: a record-linkage analysis
Authors: Parks Tom , Narube Litia , Perman Mai Ling , Sakumeni Kelera , Fong James J , Engelman Daniel , Colquhoun Samantha M , Steer Andrew C , Kado Joseph 
Published: April 2023

ObjectiveTo determine population-based rates of non-fatal complications of rheumatic heart disease (RHD).DesignRetrospective cohort study based on multiple sources of routine clinical and administrative data amalgamated by probabilistic record-linkage.SettingFiji, an upper-middle-income country, where most of the population has access to government-funded healthcare services.ParticipantsNational cohort of 2116 patients with clinically apparent RHD aged 5–69 years during 2008 and 2012.Primary and secondary outcome measuresThe primary outcome was hospitalisation for any of heart failure, atrial fibrillation, ischaemic stroke and infective endocarditis. Secondary outcomes were first hospitalisation for each of the complications individually in the national cohort as well as in hospital (n=1300) and maternity (n=210) subsets. Information on outcomes was obtained from discharge diagnoses coded in the hospital patient information system. Population-based rates were obtained using relative survival methods with census data as the denominator.ResultsAmong 2116 patients in the national cohort (median age, 23.3 years; 57.7% women), 546 (25.8%) were hospitalised for an RHD complication, a substantial proportion of all cardiovascular admissions in the country during this period in those aged 0–40 years (heart failure, 210/454, 46.3%; ischaemic stroke 31/134, 23.1%). Absolute numbers of RHD complications peaked during the third decade of life with higher population-based rates in women compared with men (incidence rate ratio 1.4, 95% CI 1.3 to 1.6, p<0.001). Hospitalisation for any RHD complication was associated with substantially increased risk of death (HR 5.4, 95% CI 3.4 to 8.8, p<0.001), especially after the onset of heart failure (HR 6.6, 95% CI 4.8 to 9.1, p<0.001).ConclusionsOur study defines the burden of RHD-attributable morbidity in the general population of Fiji, potentially reflecting the situation in low-income and middle-income countries worldwide. Hospitalisation for an RHD complication is associated with markedly increased risk of death, re-emphasising the importance of effective early prevention.
Effects of manual therapy combined with therapeutic exercise versus routine physical therapy on brain biomarkers in patients with chronic non-specific neck pain in Thailand: a study protocol for a single-blinded randomised controlled trial
Authors: Chaikla Rungtawan , Sremakaew Munlika , Kothan Suchart , Saekho Suwit , Wantanajittikul Kittichai , Uthaikhup S 
Published: April 2023

IntroductionStructural brain alterations in pain-related areas have been demonstrated in patients with non-specific neck pain. While manual therapy combined with therapeutic exercise is an effective management for neck pain, its underlying mechanisms are poorly understood. The primary objective of this trial is to investigate the effects of manual therapy combined with therapeutic exercise on grey matter volume and thickness in patients with chronic non-specific neck pain. The secondary objectives are to assess changes in white matter integrity, neurochemical biomarkers, clinical features of neck pain, cervical range of motion and cervical muscle strength.Methods and analysisThis study is a single-blinded, randomised controlled trial. Fifty-two participants with chronic non-specific neck pain will be recruited into the study. Participants will be randomly allocated to either an intervention or control group (1:1 ratio). Participants in the intervention group will receive manual therapy combined with therapeutic exercise for 10 weeks (two visits per week). The control group will receive routine physical therapy. Primary outcomes are whole-brain and regional grey matter volume and thickness. Secondary outcomes are white matter integrity (fractional anisotropy and mean diffusivity), neurochemical biomarkers (N-acetylaspartate, creatine, glutamate/glutamine, myoinositol and choline), clinical features (neck pain intensity, duration, neck disability and psychological symptoms), cervical range of motion and cervical muscle strength. All outcome measures will be taken at baseline and postintervention.Ethics and disseminationEthical approval of this study has been granted by Faculty of Associated Medical Science, Chiang Mai University. The results of this trial will be disseminated through a peer-reviewed publication.Trial registration numberNCT05568394.
Transcription factor Fli-1 impacts the expression of CXCL13 and regulates immune cell infiltration into the kidney in MRL/lpr mouse
Authors: Sato Shuzo , Zhang Xian K , Matsuoka Naoki , Sumichika Yuya , Saito Kenji , Yoshida Shuhei , Matsumoto Haruki , Temmoku Jumpei , Fujita Yuya , Asano Tomoyuki , Migita Kiyoshi 
Published: April 2023

ObjectiveFriend leukaemia virus integration 1 (Fli-1) regulates chemokine/cytokine expression and thus plays an important role in the development of lupus nephritis. Chemokine CXC ligand 13 (CXCL13) is a chemokine that promotes the formation of ectopic lymphoid structures and has been reported to be associated with the pathogenesis of lupus nephritis. The relationship between Fli-1 and CXCL13 is unknown. This study aims to elucidate whether Fli-1 impacts CXCL13 expression and contributes to the progression of lupus-like nephritis in adult MRL/lpr mouse.MethodsSerum CXCL13 levels were measured in adult wild-type (WT) MRL/lpr mice and Fli-1 heterozygote knockout (Fli-1+/−) MRL/lpr mice (4 months old or older) using ELISA. Renal mRNA expression (CXCL13 and related molecules) was measured using real-time PCR method. Kidneys were removed, stained and evaluated using a pathology scoring system. The grade of CXCL13 or CXC-chemokine receptor type 5 (CXCR5)-positive immune cell infiltration into the kidney was evaluated using immunostaining with anti-CXCL13 or anti-CXCR5 antibodies. We also used immunofluorescence staining with CXCL13- and CD11b-specific antibodies to detect the infiltration of CXCL13/CD11b double-positive immune cells.ResultsSerum CXCL13 levels in Fli-1+/−MRL/lpr mice were significantly lower than that in WT MRL/lpr mice (545.5 and 960.5 pg/mL, p=0.02). Renal expression of CXCL13 mRNA and SRY-related HMG box4 (Sox4) (an important factor for B-cell development) levels were significantly lower in Fli-1+/−MRL/lpr mice. Renal histology scores in WT MRL/lpr mice revealed significantly increased glomerular inflammation. Despite similar interstitial immune cell infiltration into the kidney, the number of CXCL13- and CXCR5-positive cells was significantly lower in Fli-1+/−MRL/lpr mice than in WT mice. Furthermore, immunofluorescence staining revealed that Fli-1+/-MRL/lpr mice had significantly fewer CXCL13/CD11b double-positive immune cells.ConclusionFli-1 regulates renal Sox4 mRNA expression and infiltration of CXCR5-positive cells as well as CXCL13/CD11b double-positive immune cells into the kidney, which affects CXCL13 expression and lupus-like nephritis.
Performance of the 2022 ACR/EULAR giant cell arteritis classification criteria for diagnosis in patients with suspected giant cell arteritis in routine clinical care
Authors: Molina-Collada Juan , Castrejón Isabel , Monjo Irene , Fernández-Fernández Elisa , Torres Ortiz Gabriela , Álvaro-Gracia Jose María , de Miguel Eugenio 
Published: April 2023

ObjectiveTo examine the performance of the new 2022 American College of Rheumatology (ACR)/EULAR giant cell arteritis (GCA) classification criteria for diagnosis in routine clinical care.MethodsMulticentric retrospective observational study of patients referred to two ultrasound (US) fast track clinics. Patients with GCA were compared with unselected controls with suspected GCA. The gold standard for GCA diagnosis has been clinical confirmation after 6 months of follow-up. All patients underwent an US exam of temporal and extracranial arteries (carotid, subclavian and axillary) at baseline. Fluorodeoxyglucose-positron emission tomography/CT was performed according to standard clinician criteria. The performance of the new 2022 ACR/EULAR GCA classification criteria was evaluated in all patients with GCA across different subsets of the disease.ResultsA total of 319 patients (188 cases, 131 controls) were included for analysis (mean age 76 years, 58.9% females). Overall, the 2022 EULAR/ACR GCA classification criteria had a sensitivity of 92.6% and a specificity of 71.8%, using GCA clinical diagnosis as external criterion and the area under the curve (AUC) was 0.928 (95% CI 0.899 to 0.957). Isolated large vessel-GCA showed a sensitivity of 62.2% and a specificity of 71.8% (AUC 0.691 (0.592 to 0.790)), while biopsy‐proven GCA showed a sensitivity of 100% and a specificity of 71.8% (AUC 0.989 (0.976 to 1)). Overall sensitivity and specificity of the 1990 ACR criteria was 53.2% and 80.2%, respectively.ConclusionsThe new 2022 ACR/EULAR GCA classification criteria showed adequate diagnostic accuracy in patients with suspected GCA under routine care, and an improvement on the sensitivity and specificity of the 1990 ACR classification criteria in all patient subsets.
Faster Supervised Average Consensus in Adversarial and Stochastic Anonymous Dynamic Networks
Authors: Kamenev Aleksandar , Kowalski Dariusz R. , Mosteiro Miguel A. 
Published: April 2023

How do we reach consensus on an average value in a dynamic crowd without revealing identity? In this work, we study the problem of average network consensus in Anonymous Dynamic Networks (ADN). Network dynamicity is specified by the sequence of topology-graph isoperimetric numbers occurring over time, which we call the isoperimetric dynamicity of the network. The consensus variable is the average of values initially held by nodes, which is customary in the network-consensus literature. Given that having an algorithm to compute the average one can compute the network size (i.e., the counting problem) and vice versa, we focus on the latter.
We present a deterministic distributed average network consensus algorithm for ADNs that we call isoperimetric Scalable Coordinated Anonymous Local Aggregation, and we analyze its performance for different scenarios, including worst-case (adversarial) and stochastic dynamic topologies. Our solution utilizes supervisor nodes, which have been shown to be necessary for computations in ADNs. The algorithm uses the isoperimetric dynamicity of the network as an input, meaning that only the isoperimetric number parameters (or their lower bound) must be given, but topologies may occur arbitrarily or stochastically as long as they comply with those parameters.
Previous work for adversarial ADNs overestimates the running time to deal with worst-case scenarios. For ADNs with given isoperimetric dynamicity, our analysis shows improved performance for some practical dynamic topologies, with cubic time or better for stochastic ADNs, and our experimental evaluation indicates that our theoretical bounds could not be substantially improved for some models of dynamic networks.
Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia
Authors: Glytsou Christina , Chen Xufeng , Zacharioudakis Emmanouil , Al-Santli Wafa , Zhou Hua , Nadorp Bettina , Lee Soobeom , Lasry Audrey , Sun Zhengxi , Papaioannou Dimitrios , Cammer Michael , Wang Kun , Zal Tomasz , Zal Malgorzata Anna , Carter Bing Z. , Ishizawa Jo , Tibes Raoul , Tsirigos Aristotelis , Andreeff Michael , Gavathiotis Evripidis , Aifantis Iannis 
Published: April 2023

Abstract

BH3 mimetics are used as an efficient strategy to induce cell death in several blood malignancies, including acute myeloid leukemia (AML). Venetoclax, a potent BCL-2 antagonist, is used clinically in combination with hypomethylating agents for the treatment of AML. Moreover, MCL1 or dual BCL-2/BCL-xL antagonists are under investigation. Yet, resistance to single or combinatorial BH3-mimetic therapies eventually ensues. Integration of multiple genome-wide CRISPR/Cas9 screens revealed that loss of mitophagy modulators sensitizes AML cells to various BH3 mimetics targeting different BCL-2 family members. One such regulator is MFN2, whose protein levels positively correlate with drug resistance in patients with AML. MFN2 overexpression is sufficient to drive resistance to BH3 mimetics in AML. Insensitivity to BH3 mimetics is accompanied by enhanced mitochondria–endoplasmic reticulum interactions and augmented mitophagy flux, which acts as a prosurvival mechanism to eliminate mitochondrial damage. Genetic or pharmacologic MFN2 targeting synergizes with BH3 mimetics by impairing mitochondrial clearance and enhancing apoptosis in AML.

Significance:
AML remains one of the most difficult-to-treat blood cancers. BH3 mimetics represent a promising therapeutic approach to eliminate AML blasts by activating the apoptotic pathway. Enhanced mitochondrial clearance drives resistance to BH3 mimetics and predicts poor prognosis. Reverting excessive mitophagy can halt BH3-mimetic resistance in AML.
This article is highlighted in the In This Issue feature, p. 1501
Filosofia, humanidades clássicas e ciências humanas e sociais: atualidade de uma agenda no Brasil de hoje
Authors: Domingues Ivan 
Published: April 2023

O artigo trata da relação entre Humanidades, Ciências Humanas e Sociais e Filosofia, considerada à luz dos projetos pedagógico e epistêmico das humanidades clássicas, tendo por fio condutor a Renascença italiana e os Studia Humanitatis, com a Filosofia como disciplina-piloto. Ao fazer o trânsito para a modernidade, com o surgimento das ciências humanas e sociais e o descentramento da filosofia, haverá o colapso dos projetos pedagógico e epistêmico dos Studia dos renascentistas, num ambiente de pesada cultura disciplinar, tendo por resultado a ultrafragmentação do conhecimento, levada a cabo sem qualquer perspectiva de unificação. O resultado é o mal-estar epistemológico, que vai junto com a ideia de perda de relevância da filosofia, ao se ver afastada dos processos pedagógico e epistêmico das ciências, e, paralelamente, das próprias disciplinas científicas, impedidas, em razão da ultrafragmentação, de nos dar uma visão unificada da humanidade e da realidade humana circundante. Tal situação levará ao questionamento acerca da oportunidade de relançamento do projeto pedagógico-epistêmico das Humanidades Clássicas, visando vencer o mal-estar epistemológico e a síndrome da irrelevância da filosofia e das ciências empíricas do homem. Contudo, como mostraremos, tal relançamento não poderá consistir numa volta aos Studia ou em sua retomada pura e simples, mas deverá dar-se em novas bases científicas e filosóficas, levado a cabo em bases interdisciplinares, e não mais holísticas, com a filosofia como disciplina-piloto, como na Renascença. Neste cenário, o Brasil será considerado e uma proposta condizente com o nosso contexto acadêmico e a realidade nacional nos dias de hoje será feita.
Super Mario Meets AI: Experimental Effects of Automation and Skills on Team Performance and Coordination
Authors: Dell'Acqua Fabrizio , Kogut Bruce , Perkowski Patryk 
Published: April 2023

Abstract
This article studies the effects of the introduction of artificial intelligence into teams in a laboratory experiment. We randomly assign automated co-workers into “laboratory firms” who are playing a team-based game on the Nintendo Switch console. We demonstrate that even in a task where AI outperforms humans, automation decreases overall team performance and increases coordination failures. These effects are especially large in the short-term and in low- and medium-skilled teams. Moreover, automation reduces team trust and individual effort provision. Our results support the implication that improving collaborative human-machine teams is key to the positive transformation that AI may bring to organizations.
Heuristics in Self-Evaluation: Evidence from the Centralized College Admission System in China
Authors: Li Hongbin , Qiu Xinyao 
Published: April 2023

Abstract
Using administrative data on the Chinese National College Entrance Examination, we study how left-digit bias affects college applications. We find strong discontinuities in students' admission outcomes at 10-point thresholds. Students with scores just below multiples of 10 make more conservative college application choices that place them into less selective colleges and majors. In contrast, students who score at or just above multiples of 10 aim and achieve higher but are at greater risk of overshooting. The discontinuity reveals that, despite the educational and labor market consequences, students' self-evaluation based on exam scores is subject to information-processing heuristics.