bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-layer seromuscular Continuous Versus Two-Layers Intestinal Anastomosis Of Small bowel in Baghdad Teaching Hospital (A prospective Study)
Authors: Habash Mohammed M. , Hammoudi Yahya K. , Sulaiman Tharwat I. 
Published: June 2023

Background: Anastomosis may be done with the help of stapling devices, by using double layered suturing technique or by a single layer technique.Patients and methods: A prospective study conducted in Baghdad Teaching Hospital, Iraq. A total of sixty- four patients were included in this study. They were divided into two groups; group A, 28 patients, single layer seromuscular continuous anastomosis was done and group B, 36 patients underwent conventional double layered anastomosis.Objective: The aim of the study is to prove that a single layer continuous technique can be constructed in a significantly less time with similar rate of complications compared with two layers technique.
Results: There were, 15 male (53.6%) and 13 (46.4%) female within group A and 20 (55.6%) male and 16 (44.4%) female within the group B. There was no significant difference in gender distribution or mean age between or within groups. Bullet and sharp nail injuries to the abdomen were the most common causative agents followed by malignant disease of GIT. Wound infection was the most frequent complication in both groups as fourteen patient out of 64 (21.9%) developed wound infection; 8 of them were among group B. There was no significant difference in the incidence of anastomotic leakage; in group A was 3.6%, while in group B was 4.7%. The average time for the construction of the single layer anastomosis was 20 min and in double layer it was 35 min. The difference in average time is statistically significant
Conclusion: The single-layer continuous anastomosis requires less time to construct and has a similar risk of leakage compared with the two-layer technique. It also costs less than any other method and can be safely introduced into a surgical training program.
HIGIENITAS DALAM BISNIS PARIWISATA: ANALISIS BIBLIOMETRIK PADA DATABASE SCOPUS
Authors: Prayitno Andaru Rachmaning Dias 
Published: June 2023

Higienitas merupakan salah satu faktor yang perlu diperbaiki guna meningkatkan produktivitas dalam sektor pariwisata. Berdasarkan laporan The Travel and Tourism Competitiveness Report yang dirilis oleh World Economic Forum (WEF) di tahun 2019, Indonesia memperoleh skor 5 dari 7. Kebersihan lingkungan, sanitasi, dan toilet menjadi tolok ukur tersendiri bagi higienitas di Indonesia dan memerlukan perhatian khusus. Penelitian ini menggunakan database scopus. Artikel ini menganalisis karakteristik publikasi, peneliti, universitas, dan kontribusi negara di bidang higienitas berwisata dari tahun 2003-2023 dengan menggunakan metode bibliometrik. Metode ini berguna karena melibatkan analisis kuantitatif sejumlah besar literatur, menggunakan metode matematika dan statistik. Hasil menunjukkan terdapat 372 dokumen dengan India, Indonesia, dan United States sebagai negara dengan artikel paling banyak diterbitkan di bidang tersebut. Adapun rekomendasi kebijakan yaitu perlu meningkatkan pembangunan dan perbaikan sarana prasarana yang dapat menunjang higienitas, sehingga wisatawan tidak ragu untuk melakukan aktivitas pariwisata. Penelitian selanjutnya diharapkan berfokus pada perilaku masyarakat terhadap pemanfaatan sarana dan prasarana penunjang pilar higienitas serta menumbuhkan kesadaran untuk menjaga keberlangsungan dalam jangka panjang.
Keywords: Higienitas, Ekonomi Pariwisata, Bibliometrik
Pengujian Erosi pada Kemiringan Dan kepadatan Tanah organik
Authors: Fatmawati Suci 
Published: June 2023

Penelitian ini memiliki latar belakang yaitu adanya kemiringan dan kepadatan tanah organik yang bervariasi sehingga sangat menentukan jumlah erosi yang terjadi pada suatu daerah sehingga diperlukan penelitian untuk mengetahui jumlah erosi yang terjadi. Rumusan masalah yang dikaji yaitu bagaimana pengaruh erosi terhadap kemiringan dan kepadatan tanah juga intensitas hujan. Penelitian ini bertujuan untuk menganalisis pengaruh serta hubungan antara erosi dengan kemiringan lereng, intensitas curah hujan dan kepadatan tanah yang terjadi pada tanah organik. Metode pembanding yang digunakan adalah USLE (Universal Soil Loss Equation) dalam menentukan jumlah erosi pada tanah yang memiliki kadar organik dengan total 18,67%. Dari penelitian yang dilakukan di laboratorium dengan tiga variasi intensitas hujan yaitu 23 mm/jam, 34 mm/jam dan 51 mm/jam didapatkan hasil berupa jumlah erosi sebesar meningkat 40 %, untuk tingkat kemiringan dengan tiga variasi yaitu 10◦, 15◦dan 20◦ menghasilkan peningkatan jumlah erosi sebesar 30 %. Hasil penelitian dengan variasi kepadatan 60% dan 70% menunjukkan hasil penurunan jumlah erosi sebesar 3 %. Dengan demikian kesimpulan yang dapat diperoleh yaitu semakin besar kemiringan lereng, intensitas hujan, dan kadar organik tanah maka erosi yang terjadi pada suatu daerah akan semakin besar pula.
Pengendalian Biaya dan Waktu dengan Metode Earned Value pada Proyek Penyelesaian Gedung Sudirman Office Kecamatan Ujung Pandang Kota Makassar
Authors: Apriansyah Aris , Bachmid Sofyan , Watono Watono , Muin Suriati Abd 
Published: June 2023

Proyek pembangunan gedung Sudirman Office Kecamatan Ujung Pandang Kota Makassar dengan nilai kontrak Rp.8.038.735.740,00 dijadwalkan selesai dalam kurun waktu 32 minggu. Dengan adanya keterlambatan selama 6 minggu dari minggu ke-8 hingga minggu ke-14 dikarenakan banyak pekerja tidak hadir seperti terisolasi di daerah dan karantina, maka dilakukan pengendalian waktu sehingga biaya akhir tidak melewati nilai kontrak. Tujuan dari penelitian ini adalah mengetahui besarnya biaya tiga indikator earned value, yaitu BCWS, BCWP, dan ACWP serta menghitung perkiraan besarnya biaya dan waktu yang diperlukan untuk penyelesaian pengerjaan proyek. Data yang didapat dari proyek antara lain Master Schedule proyek, kurva S, Rencana Anggaran Biaya (RAB), laporan mingguan proyek dan biaya aktual proyek. Metode yang digunakan pada penelitian ini adalah metode Earned Value yang didalamnya memadukan unsur biaya dan waktu serta prestasi fisik pekerjaan. Dari hasil analisa diketahui bahwa biaya yang dikeluarkan lebih besar dari biaya yang dianggarkan ditunjukkan dengan nilai CPI = 0,98 dan waktu pelaksanaan lebih lambat dari jadwal rencana ditunjukkan dengan nilai SPI = 0,84. Hasil perhitungan perkiraan biaya akhir proyek sebesar Rp.8.216.411.445,19 dengan perkiraan waktu penyelesaian 38 minggu, menunjukkan bahwa proyek mengalami keterlambatan 7 minggu dari 32 minggu yang direncanakan.
Dragon Fruit Peel Extract and Encapsulated Catfish Oil Formulation in Gummy Candy with Potential In Vitro Antihyperglycemia Properties
Authors: Aurelia Jovita , Trifena Felicia , Levi Kelvin , Marcella Maria , Septiyani  , Agustinah Widya 
Published: June 2023

Red dragon (Hylocereus polyrhizus) fruit peel as household waste was still underutilized although it was high in bioactive compounds with antioxidant and antidiabetic properties. The oil extract of freshwater fish, such as catfish (Pangasius sp.) was high in monounsaturated fatty acids with reported antihyperglycemia properties. The objectives of this study were to encapsulate catfish oil extract, determine the most liked formulation of gummy candy with dragon fruit peel extract and encapsulated fish oil beads content, and analyze the proximate content and in vitro α-amylase inhibition activity of the most liked gummy candy formulation. The methods consisted of dragon fruit peel extraction, encapsulation of catfish oil extract using sodium alginate, gummy candy formulation, sensory evaluation, and analysis of color, proximate, and α-amylase inhibition activity. Twenty five percent w/w of the gummy candy ingredients were composed of the extracts and encapsulation beads at 1:1, 1:3, and 3:1 weight ratios. Encapsulation of the fish oil could mask the fishy odor in the gummy candy. All formulation could be molded into gummy candy perfectly and showed chewy texture. The addition of dragon fruit peel extract could increase the yellowness value, while the fish oil beads decreased the lightness value of the candy. The most liked gummy candy formulation was F3 (ratio 3:1). It was composed of 54.47% water, 1.59% db ash, 5.77% db fat, 1.82% db protein, 36.36% db carbohydrates and showed 46.49% α-amylase inhibition activity.
Mesenchymal stem cells induce dynamic immunomodulation of airway and systemic immune cells in vivo but do not improve survival for mice with H1N1 virus-induced acute lung injury
Authors: Tan Yuan , Wang Yan , Souza-Moreira Luciana , Wang Chi , Murray Aidan B. P. , Salkhordeh Mahmoud , Florian Maria , McIntyre Lauralyn , Stewart Duncan J. , Mei Shirley H. J. 
Published: June 2023

Introduction: Influenza A virus (IAV)-induced acute lung injury (ALI) is characterized by pronounced proinflammatory activation and respiratory lung dysfunction. In this study, we performed deep immune profiling on airway and circulating immune cells to examine the effect of immunomodulation and therapeutic outcomes of mesenchymal stem cells (MSCs) therapy in mice with IAV-induced ALI.Methods: Animals were inoculated intranasally with H1N1 IAV, followed by intravenous administration of vehicle, or human clinical-grade, bone marrow-derived MSCs 24-h later, and monitored for six days to evaluate the survival. In another set of animals, bronchoalveolar lavage (BAL) fluid and whole blood were collected three days after infection for flow or mass cytometry (CyTOF) immune profiling analysis.Results: Immune cell population and phenotypic shifts in blood were mapped by CyTOF. Increases were observed in granulocytes and myeloid-derived cells in blood from vehicle-treated animals. While MSC treatment accentuated changes in these populations, naïve B, antibody-secreting B cells, and T cells were decreased in MSC-treated animals at day 3. Compared to sham animals, IAV infection induced a significant 5.5-fold increase in BAL total cell counts, including CD4+ and CD8+ T cells, CD19+ B cells, CD11b + Ly6G + neutrophils, and CD11b + Ly6C + monocytes. MSC treatment significantly decreased BAL total cell counts in IAV-infected mice, specifically the number of infiltrating CD4+ T cells and CD11b + Ly6G + neutrophils. In contrast, there were increases in CD8+ T cells, B cells, and monocytes in the alveolar space in MSC-treated animals. Phenotypic immune cell profiling of blood and BAL revealed a significantly higher proportion of the monocyte population with the M2 phenotype (CD206) in MSC-treated animals; however, this failed to confer protective effects in the survival of infected mice or reduce viral titer in the lung. Further investigation revealed that MSCs were susceptible to IAV infection, leading to increased cell death and potentially affecting their efficacy.Conclusion: These findings provided in vivo evidence that MSCs promote the selective recruitment of immune cells to the site of infection during IAV infection, with reductions in proinflammatory phenotypes. However, MSCs offered no survival benefit in IAV-infected animals, possibly due to MSCs’ H1N1 IAV susceptibility and subsequent cell death.
Hypertension, smoking, and preexistence of multiple cardiac risk factors correlate with carfilzomib-induced cardiovascular adverse events in a racially diverse population
Authors: Doran Stacey , Mysore Manu , Kassaian Seyed Ebrahim , Kotloff Ethan , Kamangar Farin , Emadi Ashkan , Apata Jummai , Barr Brian 
Published: June 2023

BackgroundUse of the proteasome inhibitor carfilzomib has become a standard of care in patients with relapsed/refractory multiple myeloma. An association between carfilzomib and cardiovascular adverse events has been well documented, but this had not been investigated in a racially diverse population. Black patients in particular are underrepresented in the reported outcomes of treatment with carfilzomib.ObjectiveThe purpose of this study was to identify risk factors for carfilzomib-associated cardiovascular events in a diverse, single-center population.MethodsWe conducted a retrospective review of 161 patients with multiple myeloma treated with carfilzomib between 2011 and 2020 at the University of Maryland Medical Center. Over half (86) were Black patients, with the remainder (75) being White patients. We did a multivariate analysis to determine risk factors for developing cardiovascular events during treatment with carfilzomib.ResultsThere was no statistically significant association with cardiotoxicity and race, gender, or age at first dose of carfilzomib. In multivariable analysis, patients with history of hypertension had a higher risk of cardiotoxicity [adjusted odds ratio (OR): 2.5; 95% CI: 1.1–5.9; P = 0.03] as did those with a history of smoking [OR: 2.8; 95% CI: 1.3–6.4; P = 0.01].ConclusionsHere we report the largest cohort of Black patients treated with carfilzomib as yet reported. The results of this single center retrospective study show history of hypertension and smoking are associated with carfilzomib associated cardiotoxicity in a diverse patient population. There is a need for well-designed prospective studies enrolling a diverse population to investigate potential interventions to prevent carfilzomib-associated cardiotoxicity.
Advanced perception and control method of harmful gas during construction period of coal tunnel based on DeepAR
Authors: Cao Shengye , Yang Meng , Hu Juyi , Chen Jianzhong 
Published: June 2023

Effective real-time treatment and control of harmful gases are key to ensuring the safety of tunnel construction workers. Currently, the monitoring ability of harmful gases is insufficient to match the processing needs, which poses significant risks to the safety of tunnel construction workers. This paper proposes an advanced perception and treatment method for harmful gases during tunnel construction, utilizing the DeepAR algorithm. Real-time monitoring of the concentration and diffusion of harmful gases is conducted, and a harmful gas concentration prediction model is established using the DeepAR algorithm, achieving advanced perception of harmful gases during tunnel construction. The harmful gas treatment plan is developed in advance, and the effectiveness of the proposed method is demonstrated by simulation testing under realistic field scenarios and comparing with other prediction models. The method was applied in a coal mine tunnel in Qinghai Province, achieving an accuracy rate of 94.3%, which is higher compared to those obtained using RNN and LSTM algorithms. Moreover, the computational time is less than 60 s. The method provides timely perception of the concentration distribution of harmful gases in the tunnel and proposes targeted treatment measures, verifying the effectiveness of the prediction model from the perspective of practical engineering application.
Bioinformatic analysis of the molecular mechanisms underlying the progression of bone defects
Authors: Liu Hao , Zhao Xuan , Li Yin , Yi Jiang , Zhang Chenxi , Zheng Ziyang , Dai Siming , Yin Guoyong , Zhao Shujie 
Published: June 2023

BackgroundThe pathophysiology of bone defects (BDs) is complex, and the treatment for bone defects, in particular massive bone defects, remains a major clinical challenge. Our study was conducted to explore the molecular events related to the progression of bone defects a common clinical condition.MethodsFirst, microarray data of GSE20980 were obtained from the Gene Expression Omnibus (GEO) database, where 33 samples in total were used to analyze the molecular biological processes related to bone defects. Next, the original data were normalized and differentially expressed genes (DEGs) were identified. Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted. Finally, a protein–protein interaction (PPI) network was constructed and the trends of the different genes were confirmed.ResultsCompared with the samples of non-critical size defects (NCSD), the samples of critical size defects (CSD) had 2057, 827, and 1,024 DEGs at 7, 14, and 21 days post injury, respectively. At day 7, the DEGs were significantly enriched in metabolic pathways, at day 14 the DEGs were predominantly enriched in G-protein coupled signaling pathways and the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, and at day 21 the DEGs were mainly enriched in circadian entrainment and synaptic-related functions. The PPI network showed similar results. Quantitative real-time PCR (qRT-PCR) and western blot (WB) were performed to validate the partial results of sequencing.ConclusionThis study provides some clues about the molecular mechanism behind bone defects, which should contribute to scientific research and clinical treatment of this condition.
Prevalence and risk factors of sarcopenia in idiopathic pulmonary fibrosis: a systematic review and meta-analysis
Authors: Li Jiaye , Lu Ye , Deng Mingming , Tong Run , Zhang Qin , Bian Yiding , Miao Jinrui , Wang Zilin , Zhou Xiaoming , Hou Gang 
Published: June 2023

BackgroundSarcopenia often occurs as a comorbidity in many diseases which ultimately affects patient prognosis. However, it has received little attention in patients with idiopathic pulmonary fibrosis (IPF). This systematic review and meta-analysis aimed at determining the prevalence and risk factors of sarcopenia in patients with IPF.MethodsEmbase, MEDLINE, Web of Science, and Cochrane databases were searched using relevant MeSH terms until December 31, 2022. The Newcastle-Ottawa Scale (NOS) was used for quality assessment and data analysis were performed using Stata MP 17.0 (Texas, USA). A random effects model was adopted to account for differences between articles, and the I2 statistic was used to describe statistical heterogeneities. Overall pooled estimates obtained from a random effects model were estimated using the metan command. Forest plots were generated to graphically represent the data of the meta-analysis. Meta-regression analysis was used for count or continuous variables. Egger test was used to evaluate publication bias and, if publication bias was observed, the trim and fill method was used.Main resultsThe search results showed 154 studies, and five studies (three cross-section and two cohort studies) with 477 participants were finally included. No significant heterogeneity was observed among studies included in the meta-analysis (I2 = 16.00%) and our study's publication bias is low (Egger test, p = 0.266). The prevalence of sarcopenia in patients with IPF was 26% (95% CI, 0.22–0.31). The risk factors for sarcopenia in patients with IPF were age (p = 0.0131), BMI (p = 0.001), FVC% (p &lt; 0.001), FEV1% (p = 0.006), DLco% (p ≤ 0.001), and GAP score (p = 0.003).ConclusionsThe pooled prevalence of sarcopenia in patients with IPF was 26%. The risk factors for sarcopenia in IPF patients were age, BMI, FVC%, FEV1%, DLco%, and GAP score. It is important to identify these risk factors as early as possible to improve the life quality of patients with IPF.
The micro and macro interactions in acute autoimmune encephalitis: a study of resting-state EEG
Authors: Luo Xin , Liao Jie , Liu Hong , Tang Qiulin , Luo Hua , Chen Xiu , Ruan Jianghai 
Published: June 2023

ObjectiveEarly recognition of autoimmune encephalitis (AIE) is often difficult and time-consuming. Understanding how the micro-level (antibodies) and macro-level (EEG) couple with each other may help rapidly diagnose and appropriately treat AIE. However, limited studies focused on brain oscillations involving micro- and macro-interactions in AIE from a neuro-electrophysiological perspective. Here, we investigated brain network oscillations in AIE using Graph theoretical analysis of resting state EEG.MethodsAIE Patients (n = 67) were enrolled from June 2018 to June 2022. Each participant underwent a ca.2-hour 19-channel EEG examination. Five 10-second resting state EEG epochs with eyes closed were extracted for each participant. The functional networks based on the channels and Graph theory analysis were carried out.ResultsCompared with the HC group, significantly decreased FC across whole brain regions at alpha and beta bands were found in AIE patients. In addition, the local efficiency and clustering coefficient of the delta band was higher in AIE patients than in the HC group (P &lt; 0.05). AIE patients had a smaller world index (P &lt; 0.05) and higher shortest path length (P &lt; 0.001) in the alpha band than those of the control group. Also, the AIE patients' global efficiency, local efficiency, and clustering coefficients decreased in the alpha band (P &lt; 0.001). Different types of antibodies (antibodies against ion channels, antibodies against synaptic excitatory receptors, antibodies against synaptic inhibitory receptors, and multiple antibodies positive) showed distinct graph parameters. Moreover, the graph parameters differed in the subgroups by intracranial pressure. Correlation analysis revealed that magnetic resonance imaging abnormalities were related to global efficiency, local efficiency, and clustering coefficients in the theta, alpha, and beta bands, but negatively related to the shortest path length.ConclusionThese findings add to our understanding of how brain FC and graph parameters change and how the micro- (antibodies) scales interact with the macro- (scalp EEG) scale in acute AIE. The clinical traits and subtypes of AIE may be suggested by graph properties. Further longitudinal cohort studies are needed to explore the associations between these graph parameters and recovery status, and their possible applications in AIE rehabilitation.
Development and validation of platelet-to-albumin ratio as a clinical predictor for diffuse large B-cell lymphoma
Authors: Wang Jinghan , Li Linjie , Yu Fang , Zhang Junyu , Mao Liping , Chen Bocheng , Hu Xuelian , Zhou Hongmei , Xie Wanzhuo , Tong Hongyan , Jin Jie 
Published: June 2023

IntroductionDiffuse large B-cell lymphoma (DLBCL) is the most common subtypes of lymphoma. Clinical biomarkers are still required for DLBCL patients to identify high-risk patients. Therefore, we developed and validated the platelet-to-albumin (PTA) ratio as a predictor for DLBCL patients.MethodsA group of 749 patients was randomly divided into a training set (600 patients) and an internal validation set (149 cases). The independent cohort of 110 patients was enrolled from the other hospital as an external validation set. Penalized smoothing spline (PS) Cox regression models were used to explore the non-linear relationship between the PTA ratio and overall survival (OS) as well as progression-free survival (PFS), respectively.ResultsA U-shaped relation between the PTA ratio and PFS was identified in the training set. The PTA ratio less than 2.7 or greater than 8.6 was associated with the shorter PFS. Additionally, the PTA ratio had an additional prognostic value to the well-established predictors. What’s more, the U-shaped pattern of the PTA ratio and PFS was respectively validated in the two validation sets.DiscussionA U-shaped association between the PTA ratio and PFS was found in patients with DLBCLs. The PTA ratio can be used as a biomarker, and may suggest abnormalities of both host nutritional aspect and systemic inflammation in DLBCL.