bluuebunny/crossref_metadata_2025_split huggingface dataset:
Appropriately representing convective heating is critical for predicting catastrophic heavy rainfall in 2021 in Henan Province of China
Authors: Xu Mingyue , Zhao Chun , Gu Jun , Feng Jiawang , Li Gudongze , Guo Jianping 
Published: April 2023

Abstract
An unprecedented heavy rainfall event occurred in Henan Province of central China during 19–20 July 2021 with the maximum hourly rainfall rate of 201.9 mm, which broke the historical record in mainland China. To investigate the impacts of predicted atmospheric circulation on the regional convection-permitting prediction of this event, two sets of nested experiments with different convective parameterizations (GF and MSKF) in the outer domain and at convection-permitting resolution in the inner domain are performed with the Weather Research and Forecasting (WRF) model. The analysis found the prediction of ‘21.7’ rainstorm at convection-permitting resolution in the inner domain is largely affected by convective scheme in the outer domain. The atmospheric circulation forcing from the outer domain with different convective schemes is significantly different, which ultimately affects the regional synoptic pattern and precipitation in the refined region through lateral boundary forcing. The difference in regional prediction at convection-permitting resolution can be mitigated by adjusting convective latent heat parameterization in the outer domain. This work highlights that appropriately parameterizing convective latent heat is the key to provide reasonable large-scale forcing for regionally predicting this catastrophic heavy rainfall event at convection-permitting resolution, which may also be applicable to other events and other regions.
Magnetic Li–M (M = Ni, Ni0.8Cu0.2, Cr) layered oxides nanoparticles for Li-ion batteries electrodes
Authors: Solzi M , Cugini F , Scaravonati S , Galli G , Pontiroli D , Attolini G , Besagni T , Delgado G E , Sagredo V 
Published: April 2023

Abstract
Nanoparticles of Li–Ni, Li–(Ni, Cu) and Li–Cr layered oxides, with potential applications as cathode materials in lithium batteries, were prepared by solid-state reaction and sol-gel method. The combination of structural analysis and magnetic characterization allowed the clear identification of the phases present in the synthesized nanoparticles. The main component of Li–Ni oxide nanoparticles is the electrochemically active and ferrimagnetic phase Li1−z
Ni1+z
O2, whereas those of Li–Cr oxide are the antiferromagnetic phases LiCrO2 and Cr2O3. A small substitution of Cu for Ni in Li–Ni oxide determines the formation of nanoparticles in which the main phase is the antiferromagnetic phase Li1−z
Ni1+z
O2. Operation tests in lithium batteries and post-mortem analysis, aimed at assessing the potential of metal oxide nanoparticles as cathode materials, were performed on all samples.
Investigations on mechanical and durability properties for pavement quality concrete using hybrid fibres
Authors: Mahto Shiva Kumar , Sinha Sanjeev , Venkataramana Vavitikalva , Chakravarty Hillol 
Published: April 2023

Abstract
Hybrid fiber reinforced concrete was used to develop pavement quality concrete (PQC) to overcome the disadvantages associated with rigid pavements prepared with plain cement concrete. Hooked-end steel (ST) fiber of 60 mm in length and polypropylene (PP) fiber with a length of 36 mm were used as reinforcement for the hybrid fiber concrete mix. The proportion of ST and PP fibers used was upto 1% with which PP fibers varied from 0 to 0.45% at a 0.15% increment in the total mix. This study aims to assess the various strength workability and durability issues of the concrete mixes. Significant improvement in the properties of mechanical and durability characteristics was observed in the results with the addition of these fibers as compared to control cement concrete. Among all the mix proportions, the overall performance of the mixture by adding steel fiber at 0.85% and polypropylene fiber at 0.15% contents was found to be the best. However, a slight increase in water absorption value was observed by the incorporation of fibers into concrete due to increased thickness in the transition zone and porosity.
Alternative Abdominal Wall Plication Techniques: A Review of Current Literature
Authors: Gilbert Michael M , Anderson Spencer R , Abtahi Ali R 
Published: April 2023

Abstract

Abdominoplasty is one of the most common procedures performed in plastic surgery. By removing redundant skin and fat tissue, body contouring narrows the waist and achieves a naturally flattened appearance. To achieve this, one technique frequently utilized is plication of the abdominal rectus sheath. Although abdominal wall plication is commonly performed during abdominoplasty, there is a lack of consensus regarding which plication method provides the best outcomes. Each variation addresses some of the common intraoperative and postoperative complications of abdominoplasty. These include extended operating time, rupture of the plication, epigastric bulging, and patient postoperative dissatisfaction. Many plication techniques have been described in the literature, but no single technique has been adopted by plastic surgeons as the gold standard. Here we present a narrative comparison of current published literature reporting novel or modified abdominoplasty plication techniques. This includes diagrams of each procedure, sutures utilized, and key concepts of each plication technique. Discussion regarding how these modifications change operating time, alter epigastric bulging, and improve the ability to narrow the waist is provided. The purpose of this paper is to provide a concise source document for plastic surgeons to reference when choosing a plication method to use during abdominoplasty.

Level of Evidence: 4
Cortico-limbic disruption, material-specificity, and deficits in cognitive-affective theory of mind
Authors: Singh Varsha , Grewal Kirat S , Vibha Deepti , Singh Rajesh K , Ramanujam Bhargavi , Nehra Ashima , Chandra Sarat P , Gaikwad Shailesh , Babu Indupriya , Tripathi Manjari 
Published: April 2023

Abstract
The Theory of Mind deficit due to cognitive-affective disintegration is a poorly understood cognitive consequence of cortical and subcortical disruption in right temporal lobe epilepsy. Following Marr's trilevel approach, we used the material-specific processing model to understand the Theory of Mind deficit in drug-resistant epilepsy (N = 30). We examined pre- and post-surgery changes in first-order (somatic-affective, non-verbal component) and second-order Theory of Mind (cognitive-verbal component) in three groups formed using: (i) seizure side (right versus left), (ii) right temporal epilepsy (right temporal lobe epilepsy versus non-right temporal lobe epilepsy), and (iii) right temporal lobe epilepsy with amygdalohippocampectomy (right temporal lobe epilepsy versus left temporal lobe epilepsy amygdalohippocampectomy versus non-amygdalohippocampectomy). We observed a marked deficit in the first-order Theory of Mind in the right temporal lobe amygdalohippocampectomy group; we mapped this deficit to decline in the non-verbal component of Theory of Mind (somatic-affective component). Preliminary results support using a material-specific processing model to understand the Theory of Mind deficits in right temporal lobe epilepsy amygdalohippocampectomy. Malleability of verbal processing in presence of deterioration of non-verbal processing might have clinical relevance for post-surgery recovery in right temporal lobe epilepsy amygdalohippocampectomy. Documenting the material-specific nature of deficits (verbal versus non-verbal) in non-western, linguistically, and socioeconomically diverse country enables us to understand the problem of heterogeneity in post-surgery cognitive consequences in the right amygdalohippocampectomy.
Perfusion gradients promote delayed perihaematomal oedema in intracerebral haemorrhage
Authors: Fainardi Enrico , Busto Giorgio , Scola Elisa , Casetta Ilaria , Mizutani Katsuhiro , Consoli Arturo , Boulouis Gregoire , Padovani Alessandro , Morotti Andrea 
Published: April 2023

AbstractPerihaematomal oedema is a potential therapeutic target to improve outcome of patients with intracerebral haemorrhage, but its pathophysiology remains poorly elucidated. We investigated the longitudinal changes of cerebral perfusion and their influence on perihaematomal oedema development in 150 patients with intracerebral haemorrhage who underwent computed tomography perfusion within 6 h from onset, at 24 h and at 7 days. Perfusion parameters were measured in haemorrhagic core, perihaematomal rim, surrounding normal appearing and contralateral brain tissue. Computed tomography perfusion parameters gradually improved from the core to the periphery in each time interval with an early increase at 24 h followed by a delayed decline at 7 days compared with admission values (P &lt; 0.001). Multivariable linear regression analysis showed that haematoma volume and cerebral blood flow gradient between normal appearing and perihaematomal rim were independently associated with absolute perihaematomal oedema volume in the different time points (within 6 h, B = 0.128, P = 0.032; at 24 h, B = 0.133, P = 0.016; at 7 days, B = 0.218, P &lt; 0.001). In a secondary analysis with relative perihaematomal oedema as the outcome of interest, cerebral blood flow gradient between normal appearing and perihaematomal rim was an independent predictor of perihaematomal oedema only at 7 days (B = 0.239, P = 0.002). Our findings raise the intriguing hypothesis that perfusion gradients promote perihaematomal oedema development in the subacute phase after intracerebral haemorrhage.
Glucocorticoid metabolites in an ex situ nocturnal bird, the tropical screech owl Megascops choliba: effects of sex, activity period and inter-individual variation
Authors: Barbosa-Moyano Heriberto , Sobral Gisela , de Oliveira Claudio Alvarenga 
Published: April 2023

Abstract
Glucocorticoids mediate physiological processes to obtain energy, presenting daily variation in basal levels that may be related to behavioural activity pattern. Identification of plasticity in the secretion of these hormones is essential to understand their effects on physiology and behaviour of wild birds and, therefore, their success in their natural or artificial environment. Serial endocrine evaluations are facilitated by implementing non-invasive methodologies that minimize possible effects of manipulation on the animal’s physiological variables. However, non-invasive endocrine-behavioural studies in nocturnal birds, such as owls, are immature. The present work aimed to validate an enzyme immunoassay (EIA) to quantify glucocorticoid metabolites (MGC) in Megascops choliba as well as to evaluate differences in their production at the individual, sexual or daily level. We recorded the behaviour of nine owls during three continuous days to establish activity budget under captive conditions and aiming to correlate with daily MGC variation. The EIA proved to be effective in analytical assays and in pharmacological testing with synthetic ACTH, validating this immunoassay for the species. Additionally, individual differences in MGC production were confirmed in relation to the time of day, especially at 1700 and 2100, but not in relation to sex. During night hours, the owls showed greater behavioural activity, positively related to MGC values. Higher MGC concentrations were significantly related to greater expressions of active behaviours, such as maintenance, while lower MGC concentrations were recorded during moments of higher alertness and resting. The results presented show daily MGC variation to be inversed in this nocturnal species. Our findings can aid future theoretical studies of daily rhythm and evaluations of challenging and/or disturbing situations that result in changes in behaviour or hormonal cascades of these changes in ex situ populations of owls.
Paravertebral block combined with serratus anterior plane block after video-assisted thoracic surgery: a prospective randomized controlled trial
Authors: Dusseaux Marie-Mélody , Grego Victor , Baste Jean-Marc , Besnier Emmanuel , Boujibar Fairuz , Koscianski Godefroy , Ben Yahia Mohamed Mehdi , Compere Vincent , Clavier Thomas , Vannier Margot , Selim Jean 
Published: April 2023

Abstract

OBJECTIVES
Adequate pain management after thoracoscopic surgery is a major issue in the prevention of respiratory complications. The combination of the paravertebral block (PVB) with the serratus anterior plane block (SAPB) may decrease postoperative pain. The objective of this study was to evaluate the impact of the combination of PVB and SAPB on the consumption of morphine and pain after video- or robot-assisted thoracic surgery.

METHODS
The main objective of this randomized controlled trial was to compare the cumulative postoperative morphine consumption at 24 h between a group having PVB (PVB group) and a group having PVB and SAPB (PV-SAPB group). Postoperative pain at 6 and 24 h and morphine-related complications were also assessed.

RESULTS
A total of 112 patients were included with 56 in each group. There was no difference in median cumulative morphine consumption at 24 h between the 2 groups (P = 0.1640). At 6 h, the median postoperative pain was higher in the PVB group compared to the PV-SAPB group (3 [0; 4] vs 2 [0; 3], P = 0.0231). There were no differences between the 2 groups for pain at 24 h and morphine-related complications.

CONCLUSIONS
We did not find any difference in morphine consumption between the 2 groups. Our results suggest that the combination of PVB and SAPB for video-assisted thoracic surgery or robot-assisted thoracic surgery is safe effective and reliable and could be an alternative to PVB alone in certain indications.
Acetylation of MLH1 by CBP increases cellular DNA mismatch repair activity
Authors: Zhang Mu , Zhao Jiawei , Glazer Peter M , Bai Wenlong , Bepler Gerold , Zhang Xiaohong Mary 
Published: April 2023

Abstract
The DNA mismatch repair (MMR) proteins recognize and repair DNA base pair mismatches and insertions/deletions of DNA that have occurred during DNA replication. Additionally, they are involved in regulation of the DNA damage response, including cell cycle checkpoints and apoptosis. Therefore, regulation of these proteins is essential for maintaining genomic integrity. It has been recognized that post-translational modifications, such as phosphorylation, ubiquitination, and acetylation, are being used as an important means to regulate the functions and stability of MMR proteins. Here, we report that a histone acetyltransferase CREB binding protein (CBP) interacts with and acetylates MLH1, a component of the MutLα complex (MLH1–PMS2). Moreover, CBP stabilizes MLH1 by preventing it from degradation via the ubiquitin–proteasome degradation pathway. Consistently, acetylation induced by a pan-histone deacetylase inhibitor, Trichostatin A, promotes the assembly between the MutSα (MSH2–MSH6) and MutLα complexes. Furthermore, overexpression of CBP enhances MMR activities in cells. Overall, our results suggest a novel role of CBP in prolonging MLH1 stability and enhancing MutSα–MutLα complex formation, leading to increased cellular MMR activity.
Beauveria bassiana rewires molecular mechanisms related to growth and defense in tomato
Authors: Proietti Silvia , Falconieri Gaia Salvatore , Bertini Laura , Pascale Alberto , Bizzarri Elisabetta , Morales-Sanfrutos Julia , Sabidó Eduard , Ruocco Michelina , Monti Maurilia M , Russo Assunta , Dziurka Kinga , Ceci Marcello , Loreto Francesco , Caruso Carla 
Published: April 2023

Abstract
Plant roots can exploit beneficial associations with soil-inhabiting microbes, promoting growth and expanding the immune capacity of the host plant. In this work, we aimed to provide new information on changes occurring in tomato interacting with the beneficial fungus Beauveria bassiana. The tomato leaf proteome revealed perturbed molecular pathways during the establishment of the plant–fungus relationship. In the early stages of colonization (5–7 d), proteins related to defense responses to the fungus were down-regulated and proteins related to calcium transport were up-regulated. At later time points (12–19 d after colonization), up-regulation of molecular pathways linked to protein/amino acid turnover and to biosynthesis of energy compounds suggests beneficial interaction enhancing plant growth and development. At the later stage, the profile of leaf hormones and related compounds was also investigated, highlighting up-regulation of those related to plant growth and defense. Finally, B. bassiana colonization was found to improve plant resistance to Botrytis cinerea, impacting plant oxidative damage. Overall, our findings further expand current knowledge on the possible mechanisms underlying the beneficial role of B. bassiana in tomato plants.
A new perspective on completeness and finitist consistency
Authors: Santos Paulo Guilherme , Sieg Wilfried , Kahle Reinhard 
Published: April 2023

Abstract
In this paper, we study the metamathematics of consistent arithmetical theories $T$ (containing $\textsf {I}\varSigma _{1}$); we investigate numerical properties based on proof predicates that depend on numerations of the axioms. Numeral Completeness. For every true (in $\mathbb {N}$) sentence $\vec {Q}\vec {x}.\varphi (\vec {x})$, with $\varphi (\vec {x})$ a $\varSigma _{1}(\textsf {I}\varSigma _1)$-formula, there is a numeration $\tau $ of the axioms of $T$ such that $\textsf {I}\varSigma _1\vdash \vec {Q}\vec {x}. \texttt {Pr}_{\tau }(\ulcorner \varphi (\overset {\text{.} }{\vec {x}})\urcorner )$, where $\texttt {Pr}_{\tau }$ is the provability predicate for the numeration $\tau $.
Numeral Consistency. If $T$ is consistent, there is a $\varSigma _{1}(\textsf {I}\varSigma _1)$-numeration $\tau $ of the axioms of $\textsf {I}\varSigma _{1}$ such that $\textsf {I}\varSigma _1\vdash \forall\, x. \texttt {Pr}_{\tau }(\ulcorner \neg \textit {Prf}(\ulcorner \perp \urcorner , \overset {\text{.}}{x})\urcorner )$, where $\textit {Prf}(x,y)$ denotes a $\varDelta _{1}(\textsf {I}\varSigma _1)$-definition of ‘$y$ is a $T$-proof of $x$’. Finitist consistency is addressed by generalizing a result of Artemov:
Partial finitism. If $T$ is consistent, there is a primitive recursive function $f$ such that, for all $n\in \mathbb {N}$, $f(n)$ is the code of an $\textsf {I}\varSigma _{1}$-proof of $\neg\, \textit{Prf}(\ulcorner \perp \urcorner ,\overline {n})$.
These results are not in conflict with Gödel’s Incompleteness Theorems. Rather, they allow to extend their usual interpretation and show a deep connection to reflections in Hilbert’s last papers of 1931.
Stable bulged G-quadruplexes in the human genome: identification, experimental validation and functionalization
Authors: Papp Csaba , Mukundan Vineeth T , Jenjaroenpun Piroon , Winnerdy Fernaldo Richtia , Ow Ghim Siong , Phan Anh Tuân , Kuznetsov Vladimir A 
Published: April 2023

Abstract
DNA sequence composition determines the topology and stability of G-quadruplexes (G4s). Bulged G-quadruplex structures (G4-Bs) are a subset of G4s characterized by 3D conformations with bulges. Current search algorithms fail to capture stable G4-B, making their genome-wide study infeasible. Here, we introduced a large family of computationally defined and experimentally verified potential G4-B forming sequences (pG4-BS). We found 478 263 pG4-BS regions that do not overlap ‘canonical’ G4-forming sequences in the human genome and are preferentially localized in transcription regulatory regions including R-loops and open chromatin. Over 90% of protein-coding genes contain pG4-BS in their promoter or gene body. We observed generally higher pG4-BS content in R-loops and their flanks, longer genes that are associated with brain tissue, immune and developmental processes. Also, the presence of pG4-BS on both template and non-template strands in promoters is associated with oncogenesis, cardiovascular disease and stemness. Our G4-BS models predicted G4-forming ability in vitro with 91.5% accuracy. Analysis of G4-seq and CUT&Tag data strongly supports the existence of G4-BS conformations genome-wide. We reconstructed a novel G4-B 3D structure located in the E2F8 promoter. This study defines a large family of G4-like sequences, offering new insights into the essential biological functions and potential future therapeutic uses of G4-B.
DIANA-microT 2023: including predicted targets of virally encoded miRNAs
Authors: Tastsoglou Spyros , Alexiou Athanasios , Karagkouni Dimitra , Skoufos Giorgos , Zacharopoulou Elissavet , Hatzigeorgiou Artemis G 
Published: April 2023

Abstract
DIANA-microT-CDS is a state-of-the-art miRNA target prediction algorithm catering the scientific community since 2009. It is one of the first algorithms to predict miRNA binding sites in both the 3′ Untranslated Region (3′-UTR) and the coding sequence (CDS) of transcripts, with increased performance. Its current version, DIANA-microT 2023 (www.microrna.gr/microt_webserver/), brings forward a significantly updated set of interactions. DIANA-microT-CDS has been executed utilizing annotation information from Ensembl v102, miRBase 22.1 and, for the first time, MirGeneDB 2.1, yielding more than 83 million interactions in human, mouse, rat, chicken, fly and worm species. Additionally, this version delivers predicted interactions of miRNAs encoded from 20 viruses against host transcripts from human, mouse and chicken species. Numerous resources have been interconnected into DIANA-microT, including DIANA-TarBase, plasmiR, HMDD, UCSC, dbSNP, ClinVar, as well as miRNA/gene abundance values for 369 distinct cell-lines/tissues. The server interface has been redesigned allowing users to use smart filtering options, identify abundance patterns of interest, pinpoint known SNPs residing on binding sites and obtain miRNA-disease information. The contents of DIANA-microT webserver are freely accessible and can also be locally downloaded without any login requirements.
SUP: a probabilistic framework to propagate genome sequence uncertainty, with applications
Authors: Becker Devan , Champredon David , Chato Connor , Gugan Gopi , Poon Art 
Published: April 2023

AbstractGenetic sequencing is subject to many different types of errors, but most analyses treat the resultant sequences as if they are known without error. Next generation sequencing methods rely on significantly larger numbers of reads than previous sequencing methods in exchange for a loss of accuracy in each individual read. Still, the coverage of such machines is imperfect and leaves uncertainty in many of the base calls. In this work, we demonstrate that the uncertainty in sequencing techniques will affect downstream analysis and propose a straightforward method to propagate the uncertainty. Our method (which we have dubbed Sequence Uncertainty Propagation, or SUP) uses a probabilistic matrix representation of individual sequences which incorporates base quality scores as a measure of uncertainty that naturally lead to resampling and replication as a framework for uncertainty propagation. With the matrix representation, resampling possible base calls according to quality scores provides a bootstrap- or prior distribution-like first step towards genetic analysis. Analyses based on these re-sampled sequences will include a more complete evaluation of the error involved in such analyses. We demonstrate our resampling method on SARS-CoV-2 data. The resampling procedures add a linear computational cost to the analyses, but the large impact on the variance in downstream estimates makes it clear that ignoring this uncertainty may lead to overly confident conclusions. We show that SARS-CoV-2 lineage designations via Pangolin are much less certain than the bootstrap support reported by Pangolin would imply and the clock rate estimates for SARS-CoV-2 are much more variable than reported.