bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-step offer and return of multiple types of additional genomic findings to families after ultrarapid trio genomic testing in the acute care setting: a study protocol
Authors: Bouffler Sophie E , Lee Ling , Lynch Fiona , Martyn Melissa , Lynch Elly , Macciocca Ivan , Curnow Lisette , McCorkell Giulia , Lunke Sebastian , Chong Belinda , Marum Justine E , Delatycki Martin , Downie Lilian , Goranitis Ilias , Vears Danya F , Best Stephanie , Clausen Marc , Bombard Yvonne , Stark Zornitza , Gaff Clara L 
Published: June 2023

IntroductionAs routine genomic testing expands, so too does the opportunity to look for additional health information unrelated to the original reason for testing, termed additional findings (AF). Analysis for many different types of AF may be available, particularly to families undergoing trio genomic testing. The optimal model for service delivery remains to be determined, especially when the original test occurs in the acute care setting.Methods and analysisFamilies enrolled in a national study providing ultrarapid genomic testing to critically ill children will be offered analysis for three types of AF on their stored genomic data: paediatric-onset conditions in the child, adult-onset conditions in each parent and reproductive carrier screening for the parents as a couple. The offer will be made 3–6 months after diagnostic testing. Parents will have access to a modified version of the Genetics Adviser web-based decision support tool before attending a genetic counselling appointment to discuss consent for AF. Parental experiences will be evaluated using qualitative and quantitative methods on data collected through surveys, appointment recordings and interviews at multiple time points. Evaluation will focus on parental preferences, uptake, decision support use and understanding of AF. Genetic health professionals’ perspectives on acceptability and feasibility of AF will also be captured through surveys and interviews.Ethics and disseminationThis project received ethics approval from the Melbourne Health Human Research Ethics Committee as part of the Australian Genomics Health Alliance protocol: HREC/16/MH/251. Findings will be disseminated through peer-review journal articles and at conferences nationally and internationally.
Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism
Authors: Althoff Meghan Dolan , Peterson Ryan , McGrath Max , Jin Ying , Grasemann Hartmut , Sharma Sunita , Federman Alex , Wisnivesky Juan Pablo , Holguin Fernando 
Published: June 2023

BackgroundThe L-arginine metabolome is dysregulated in asthma, though it is not understood how longitudinal changes in L-arginine metabolism differ among asthma phenotypes and relate to disease outcomes.ObjectivesTo determine the longitudinal associations between phenotypic characteristics with L-arginine metabolites and their relationships with asthma morbidity.MethodsThis is a prospective cohort study of 321 patients with asthma followed semiannually for over 18 months with assessments of plasma L-arginine metabolites, asthma control, spirometry, quality of life and exacerbations. Metabolite concentrations and ratios were transformed using the natural logarithm.ResultsThere were many differences in L-arginine metabolism among asthma phenotypes in the adjusted models. Increasing body mass index was associated with increased asymmetric dimethylarginine (ADMA) and depleted L-citrulline. Latinx was associated with increased metabolism via arginase, with higher L-ornithine, proline and L-ornithine/L-citrulline levels, and was found to have higher L-arginine availability compared with white race. With respect to asthma outcomes, increasing L-citrulline was associated with improved asthma control and increasing L-arginine and L-arginine/ADMA were associated with improved quality of life. Increased variability in L-arginine, L-arginine/ADMA, L-arginine/L-ornithine and L-arginine availability index over 12 months were associated with increased exacerbations, OR 4.70 (95% CI 1.35 to 16.37), OR 8.69 (95% CI 1.98 to 38.08), OR 4.17 (95% CI 1.40 to 12.41) and OR 4.95 (95% CI 1.42 to 17.16), respectively.ConclusionsOur findings suggest that L-arginine metabolism is associated with multiple measures of asthma control and may explain, in part, the relationship between age, race/ethnicity and obesity with asthma outcomes.
Correlation between gestational age and level of sensory block in spinal
anesthesia
Authors: Kim Hyunjee 
Published: June 2023

Background and objectives
To identify a specific correlation between progression of
gestational age and level of sensory block in spinal anesthesia in
patients undergoing cervical cerclage.

Methods
The medical records of patients who underwent cervical cerclage
under spinal anesthesia using hyperbaric bupivacaine between March 2016
and May 2018 were retrospectively reviewed. The primary outcome measure
was the correlation between gestational age and sensory block level of
spinal anesthesia. Secondary outcomes included the correlations between
gestational age and reduction in blood pressure and length of the
postanesthesia care unit (PACU) stay. The Pearson correlation test,
partial correlation test, and linear regression were used to identify
relationships and to adjust for confounding variables.

Results
Of the 261 cases reviewed, there was a linear and significant
correlation between gestational age and sensory block level, reduction
in systolic blood pressure during surgery, reduction in systolic blood
pressure during PACU, and length of PACU stay, after adjusting for
confounding factors (partial correlation coefficient=0.71, p<0.001;
0.27, p<0.001; 0.25, p<0.001; 0.21, p=0.001, respectively). A
1-day increase in gestational age corresponded to an increase of 0.04
dermatomes in sensory block level (95% CI 0.035 to 0.045,
p<0.001).

Conclusion
Results demonstrated that as the gestational age progressed, sensory
block level increased, blood pressure was decreased, and length of PACU
stay increased after spinal anesthesia. Sensory block increased by 0.28
dermatomes when the pregnancy progressed 1 week. Further controlled
prospective studies are needed to support this relationship.

Trial registration number
NCT0000538.
AN ADAPTIVE ELLIPTICAL CURVE CRYPTOGRAPHY-RIVEST-SHAMIR-ADLEMAN-BASED ENCRYPTION FOR IoT HEALTHCARE SECURITY MODEL WITH BLOCKCHAIN TECHNOLOGY
Authors: MOHANA M. , DEOTARE VILAS V. , PREETHA N. S. NINU , BRAMMYA G. 
Published: June 2023

The healthcare systems follow the path of client-server architecture in a centralized manner for managing the patient’s health information with the secure storage process. Medical data can be preserved in every medical institution that remains safely in silos. It could be able to access without proper authorization and cannot be transferred. At the same time, while handling massive data, the clinics or hospitals are fragile enough to govern the patient’s health information as the system is confined with such security constraints. Rather than other methodologies, blockchain plays a pivotal part in the medical industry for storing medical data in a secure manner. Since the blockchain represents a reliable and scalable decentralized network, it can conquer certain challenges of classical methods. Furthermore, the Internet of Things (IoT) is an emerging process of fetching data by wearing some sensors and devices. Through these intelligent elements, the healthcare data can be shared and enriched with the data quality for effective healthcare services. Nevertheless, this connection becomes vulnerable to data privacy and security because the data management relies on open service networks. In order to overcome these effects, a novel IoT-derived blockchain model is proposed for storing and authenticating purposes. Initially, medical data are collected from different benchmark sources and subjected to the data encryption phase. Then, encryption is performed with the help of Adaptive Elliptical Curve Cryptography and Rivest-Shamir-Adleman (A-ECC-RSA), where the key optimization is done by utilizing Enhanced Sand Cat Swarm Optimization (ESCSO). Further, encrypted data are stored in the blockchain and finally authentication access is performed with the help of Adaptive Bidirectional Long Short-Term Memory (ABiLSTM) using biometric information, where the BiLSTM parameters are optimally selected by developed ESCSO. Thus, the developed model will attain an effective security rate than conventional models that can be established through several experiments on the proposed model.
Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold
Authors: Griessinger Emmanuel , Pereira-Martins Diego , Nebout Marielle , Bosc Claudie , Saland Estelle , Boet Emiline , Sahal Ambrine , Chiche Johanna , Debayle Delphine , Fleuriot Lucile , Pruis Maurien , De Mas Véronique , Vergez François , Récher Christian , Huls Gerwin , Sarry Jean-Emmanuel , Schuringa Jan Jacob , Peyron Jean-François 
Published: June 2023

Abstract

Dependency on mitochondrial oxidative phosphorylation (OxPhos) is a potential weakness for leukemic stem cells (LSC) that can be exploited for therapeutic purposes. Fatty acid oxidation (FAO) is a crucial OxPhos-fueling catabolic pathway for some acute myeloid leukemia (AML) cells, particularly chemotherapy-resistant AML cells. Here, we identified cold sensitivity at 4°C (cold killing challenge; CKC4), commonly used for sample storage, as a novel vulnerability that selectively kills AML LSCs with active FAO-supported OxPhos while sparing normal hematopoietic stem cells. Cell death of OxPhos-positive leukemic cells was induced by membrane permeabilization at 4°C; by sharp contrast, leukemic cells relying on glycolysis were resistant. Forcing glycolytic cells to activate OxPhos metabolism sensitized them to CKC4. Lipidomic and proteomic analyses showed that OxPhos shapes the composition of the plasma membrane and introduces variation of 22 lipid subfamilies between cold-sensitive and cold-resistant cells. Together, these findings indicate that steady-state energy metabolism at body temperature predetermines the sensitivity of AML LSCs to cold temperature, suggesting that cold sensitivity could be a potential OxPhos biomarker. These results could have important implications for designing experiments for AML research to avoid cell storage at 4°C.

Significance:
Mitochondrial metabolism fueled by FAO alters the membrane composition and introduces membrane fragility upon cold exposure in OxPhos-driven AML and in LSCs.
See related commentary by Jones, p. 2441
Patient-Centric Approaches for Phase I Combination Trials Come on Stage
Authors: Hernando-Calvo Alberto , Garralda Elena 
Published: June 2023

Summary:A disruptive clinical trial design allowed Drilon and colleagues to demonstrate proof of concept of the potential of PF-07284892 to overcome resistance mechanisms to targeted therapies in the clinic.See related article by Drilon et al., p. 1789 (7).
Association Between the Route of Administration and Formulation of Estrogen Therapy and Hypertension Risk in Postmenopausal Women: A Prospective Population-Based Study
Authors: Kalenga Cindy Z. , Metcalfe Amy , Robert Magali , Nerenberg Kara A. , MacRae Jennifer M. , Ahmed Sofia B. 
Published: June 2023

Background:
Hypertension is the leading global cause of cardiovascular disease and premature mortality in women. The effects of postmenopausal hormone therapy (HT) on blood pressure are uncertain but may be related to route of estrogen administration and formulation of estrogen. We sought to determine the association between route of administration and formulation of estrogen HT and hypertension risk in postmenopausal women.

Methods:

Population-based cohort study with women aged ≥45 years who filled ≥2 consecutive prescriptions for estrogen-only HT, identified from linked provincial health administrative data from Alberta, Canada, between 2008 and 2019. The primary outcome, incident hypertension, was identified using standardized
International Classification of Diseases
,
Ninth and Tenth Revision
. Cox proportional hazard models were used to calculate hazard ratios (HRs) for hypertension in women using oral HT compared with nonoral HT (transdermal, vaginal, or intramuscular).

Results:
In total, 112 240 women used an estrogen-only form of HT. Oral estrogen was associated with a higher risk of hypertension compared with both transdermal (HR, 1.14 [95% CI, 1.08–1.20]) and vaginal (HR, 1.19 [95% CI, 1.13–1.25]) estrogens. Conjugated equine estrogen was associated with an increased risk of hypertension compared with estradiol (HR, 1.08 [95% CI, 1.04–1.14]) but not estrone (HR, 1.00 [95% CI, 0.93–1.10]). Duration of estrogen exposure and cumulative dose of estrogen was positively associated with risk of hypertension.

Conclusions:
Oral estrogen-only HT use was associated with an increased risk of hypertension in women. In women using estrogen-only HT, nonoral estradiol at the lowest dose and for the shortest time-period is associated with the lowest risk of hypertension.
Accuracy of Measurements of the Structural Reserve for Upper Limb Function in Patients With Moderate-to-Severe Stroke
Authors: Yoo Yeun Jie , Jun So Yeon , Park Eun Jin , Kim Youngkook 
Published: June 2023

BACKGROUND:
The structural integrity of the corticospinal tract (CST) is an important biomarker of poststroke upper limb recovery. Injured CST undergoes Wallerian degeneration rostrocaudally during the first few months. However, there is no standardized measurement of the structural integrity of the CST. This study aimed to determine the measurement accuracy of the structural integrity of the CST.

METHODS:
This cross-sectional study included 50 consecutive patients with middle cerebral artery stroke who underwent diffusion tensor imaging upon transfer from the acute stroke unit to the inpatient rehabilitation facility (2018–2022). We evaluated hemiplegic upper limb function using Shoulder Abduction and Finger Extension (SAFE) scores. Fractional anisotropy values representing the structural integrity of the CST were evaluated using 4 region of interest-based and 2 tract-based measurements, including the posterior limb of internal capsule, cerebral peduncle, pons, pontomedullary junction, entire CST, and CST in the brainstem. Multivariate linear regression models and the area under the curve (AUC) were used to determine measurement accuracy for hemiplegic upper limb function.

RESULTS:

The structural integrity of the CST at the pontomedullary junction showed the highest explanatory power, followed by the entire CST, in the multivariate linear regression models (adjusted R
2
=
0.459 and 0.425, respectively). The structural integrity of the CST at the pontomedullary junction also showed the highest AUC, followed by the entire CST, in discriminating patients with a SAFE score of <8 or 5 from those with SAFE ≥8 or 5 (SAFE <8: AUC, 0.90 [95% CI, 0.80–1.00]; AUC, 0.83 [0.66–0.99]; SAFE <5: AUC, 0.87 [0.77–0.96]; AUC, 0.83, [0.72–0.95], respectively).

CONCLUSIONS:
The structural integrity of the CST measured at the pontomedullary junction or entire CST demonstrated the highest accuracy for hemiplegic upper limb function in the subacute phase of stroke.
Where Are Children in Missiology? English- Language Publications over the Past Decades
Authors: Scott David H. 
Published: June 2023

Abstract
Twenty-five years ago, it was claimed that only two articles existed in missiological journals that directly considered children and mission together. This article updates and systematizes that research, analyzing the results in English-language publications decade-by-decade in conversation with other trends to better understand and engage with children and young people in the church, in the world, and in the academy. It observes that the number and quality of missiological research and writing related to children and mission in academic journals has greatly expanded over the past decades, even if there is room for further growth.
Spirit-Possession in Fiji: The Pastoral Challenges of Discerning and Healing
Authors: Hoare Francis 
Published: June 2023

Abstract
Spirit possession elicits two common responses – rites to exorcise Satan or medical intervention. Drawing on pastoral experiences in the two major cultures of Fiji, this paper examines different types of spirit possession from the perspectives of social anthropology, psychology, and theology, which all play important roles in dealing with cases of spirit possession. Understanding of and communication within the local cosmology is important. Pastoral discernment is emphasized, especially in cases of ancestor possession, which are common in the indigenous Fijian culture. The character of the pastoral worker and relationship with the patient are also of great importance in the healing process. So too is the healing power of religious ritual and symbol, as will be shown in cases of possession within both cultures. To achieve as accurate a diagnosis as possible, a mixture of spirituality, psychology, and socio-cultural analysis may be necessary for healing.
The Northern League (1991–2020)
Authors: Bouillaud Christophe 
Published: June 2023

Abstract
This article aims to clarify the attitude of the Italian Northern League (Lega Nord) toward the Catholic Church and Catholic faith, since its creation in 1991. The article examines the evolution of the party from the merger of the northern regionalist parties under the leadership of Umberto Bossi (1991–2012) until its current form and its reengineering by its new leader, Matteo Salvini, as a national(ist) League (Lega) aiming to win votes and mandates all over Italy and to become the dominant party of the Italian right. Be it under Bossi or Salvini, the Lega Nord/Lega has always opposed both the humanist teaching of the Catholic Church and mainstream Catholic social organizations, while pretending to defend the “Catholic identity” of the “North,” before turning to the entire country. Under Salvini’s leadership, the Lega joined forces with some rightist Catholic groups prone to complain about Pope Francis’s deemed treason of the Catholic identity, and so reinforced its conservative orientation. As I will show in this article, in the medium term, the enduring success of the Lega Nord/Lega illustrates the decline of mainstream Catholicism in Italy.
Brentano on Act, Content and Intentionality
Authors: Textor Mark 
Published: June 2023

Abstract
This article offers a reconstruction of Brentano’s notion of act content that identifies the content of a mental act with a combination of marks (Merkmale) or a single such mark. The author will first clarify the role act content plays in Brentano’s philosophy of psychology and then go on to locate the proposed notion of content in the historical context of Brentano’s work as well as in his writings at the time of Psychologie. The author will defend this notion against potential objections and explore its explanatory potential.
Judgement and Intentionality in Early Brentano
Authors: van der Schaar Maria 
Published: June 2023

Abstract
There are two notions of intentionality: the first contains the thesis that our acts of thinking, judging and loving have a content; the second that our mental acts are about something external to the act. Brentano uses the term ‘intentionality’ only in relation to the first notion; for him, intentionality does not function as a bridge between the mind and the external world. Is it possible for a phenomenologist like Brentano to give an account of the second notion of intentionality? It is argued that this is possible, but not without introducing the notion of judgement. A comparison with Mill’s distinction between connotation and denotation, and with Frege’s distinction between sense and reference shows how original Brentano’s theory is.
Von den mannigfachen Ausdrücken der „intentionalen Inexistenz“ bei Franz Brentano
Authors: Marques de Carvalho Joelma 
Published: June 2023

Abstract
In this article I provide an overview of the many different terms that Brentano sometimes uses as synonyms or as explanations for “intentional inexistence”. The many terms associated with intentional inexistence appear in many different contexts, and we can conclude that Brentano uses these terms primarily to describe a property that is accidental and dependent on the subject from which it arises and with which it passes away. Ontologically, both properties and substances exist, but the former requires a substance (the subject) for its existence. A mental act is to be considered as a first-order property, whereas the content (or part of the mental act) can be understood as an accident of that accident.
Das intentionale Objekt als Unding
Authors: Ierna Carlo 
Published: June 2023

Abstract
The so-called “intentional object” occupies a central position in the debates about intentionality in Brentano and the Brentano School. How does it relate to the correlate, the content, or the intended, possibly external, transcendent object? Does it perhaps even coincide with one of these? There was no clear consensus on this neither in Brentano’s time nor today. In order to develop a new perspective on the problem of the intentional object, I would like to introduce a deliberately radical interpretation and related terminological change: what if we were to avoid any talk of “object” in this context altogether? Perhaps this could help avoid the ambiguities and misunderstandings associated with talk of “intentional objects.” In my contribution I would like to sketch such an interpretation and consider whether this attempt could be useful to reframe the debate.
Der Gegenstandsbegriff als terminologische Hürde für Brentanos Konzeption intentionaler Inexistenz
Authors: Brandl Johannes L. 
Published: June 2023

Abstract
Brentano’s use of the expression ‘intentional inexistence’ poses a considerable terminological problem. This is due not only to the expressions ‘intentional’ and ‘inexistence’ contained in it. The biggest hurdle is the liberal use of the expression ‘object’, which is encouraged by Brentano’s notion of intentional inexistent (or immanent) objects. Carlo Ierna tries to meet this problem with a strategy that allows to hold on to the notion of intentional inexistence without accepting immanent objects. The originality of his interpretation lies, as I will show in my commentary, in the fact that it tries to achieve its goal by terminological measures alone. Following the same line, I will argue that Brentano’s self-correction, made in the second edition of his Psychology, can also be interpreted in this context as a terminological move.
Streiten über Geschmack
Authors: Luxenburger Matthias 
Published: June 2023

Abstract
The aim of this article is to refute the aphorism “There is no arguing about taste”. On the one hand, judgements of taste arise from individual feelings, on the other hand, they claim to be universally valid. The question of whether there can be sensible dispute about taste arises from this conflict between subjectivity and universality. The article shows how sensible dispute is possible without denying the subjective character of the judgement. Dispute leads to an explication of the standard that determined the individual judgement of taste. Based on this, three stages of sensible dispute open up: adjustment of the standard, improvement of the standard, and idealisation of the standard. Thus, the article demonstrates not only that it is possible to argue about taste in a sensible way, but also on which levels such a dispute can take place.