bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization, synthesis, and characterization of co-electrospinning cellulose acetate/thermoplastic polyurethanes composite membrane for photodynamic antibacterial application
Authors: Hu Xianjin , Li Ting-Ting , Yang Lu , Zhang Ying , Shen Baolei , Ren Hai-Tao , Lin Jia-Horng , Lou Ching-Wen 
Published: March 2023

Abstract

Photodynamic antibacterial composite membranes were engineered by integrating photosensitizer/ antibacterial agent, into the polyurethane adhesive blend and coating the blend on co-electrospinning cellulose acetate(CA)/thermoplastic polyurethanes(TPU) composite membrane support for enhanced antibacterial performance. The central composite design (CCD) method based on the response surface method (RSM) was used for analysis to illustrate the influence of important variables. The optimized parameters of CCD were TPU (wt%) 22.64%, CA (wt%) 18.63, DMAC/acetone volume ratio 0.85, LiCl (wt%) 0.95%, voltage (kV) 23.33kV. Fiber diameter was the key response process output variable. The membranes were characterized by SEM, XPS, and molecular structure analyses. The model had excellent applicability as a tool to realize the average diameter of the CA/TPU bicomponent electrospun membrane. Results showed that after coating, the synergistic effects of photodynamic antibacterial and antibacterial agent performance on the Antibacterial composite membrane were achieved under ordinary daylight irradiation. The sterilization rate ofS. aureusandE. colicould achieve excellence at 99.2% and 93.4%, respectively. This method of preparing photodynamic antibacterial composite film provides a new direction for the design of medical antibacterial protective materials.
Grundy Number based Optimal Sensor Placement in 3D Wireless Sensor Networks
Authors: S Afizudeen , R Pavithra 
Published: March 2023

Abstract
Wireless sensor network (WSN) is recent occurrence in various domestic and industrial areas to collect reliable data using inter-linked intelligent sensors. The deployment of more sensors has an impact on the environment and consumes more energy since, these sensors communicate and transmits the data wirelessly. Thus, the efficient placement of sensors maximizes the network lifetime and minimizes the energy consumption. Many previous works of literature are replete with studies on coverage and connectivity satisfying Quality of Service (QoS) requirements in a two-dimensional area. In some applications that operate in real-time environment, the sensors are usually placed over three-dimensional volume. Hence, this paper focuses on coverage and connectivity problem which obliged under target Q-coverage constraint in 3D-terrain. A Grundy Number based DeterministicSensor Deployment (GN-DSD) algorithm is proposed to identify the sensor requirements and its optimal coordinates to achieve coverage requirement for targets. Additionally, a relay node deployment method is proposed to improve the network connectivity in 3D-terrain using Breadth First Search approach. Further, to increase the optimality for sensor coordinates, Grundy Number based Random Deployment algorithm (GN-RDA), Grundy Number based Cuckoo Search algorithm (GN-CSA) and Grundy Number based Genetic algorithm (GN-GA) are utilized. A series of simulation are done with various parameters, out of which GN-GA outperforms the existing algorithms.
Observe the therapeutic effect of EEG biofeedback on 82 patients with insomnia
Authors: Wang Huicong , Hou Yue , Wang Yuping , wang Hongxing , zhan shuqin , li ning , liu jianghong 
Published: March 2023

AbstractObjective:Insomniais the most prevalent clinical sleep disorder and is usually accompanied by some affective symptoms. To some extent, traditional interventions for insomnia remain some shortcomings. Hence, exploring potential novel interventions for insomnia is of great clinical significance. Recently, the biofeedback therapy (i.e. the electroencephalography EEG and electromyography EMG feedback) has been regarded as a new method for the treatment of insomnia following medication and physical therapy, where EEG information is fed back to the subject for the purpose of self-regulation of EEG activity. We aimed to explore the clinical efficacy of biofeedback for insomnia and its potential mechanisms.Methods:We recruited 82 patients with insomnia from the insomnia clinic of Xuanwu Hospital in this research. The EEG and EMG biofeedback training were conducted for 30 minutes. The EEG data of two minutes were also recorded each before and after the training section. The intervention was performed once every other day and included 10 times treatments in total. The Becker Depression Scale(BDI), state anxiety (S-STAI) and trait anxiety (T-STAI) of Spielberger State-Trait Anxiety Inventory (STAI), and Pittsburgh Sleep Quality Index(PQRI) scales were administered three times before treatment and after 1 treatment session, respectively.Results:Results showed that the scores of the PQRI scale after 1 trial of biofeedback treatmentwere significantly lower than those before treatment (p< 0.001). Furthermore, the score of the PQRI following 10 trials of biofeedback treatments were significantly lower than values following 5 trials of treatments (p< 0.001). More specifically, patients experienced a significant reduction in insomnia, an easier transition to natural sleep, a shorter time to fall asleep, fewer awakenings during sleep, and a much better quality of sleep. In addition, the scores of the BDI, S-STAI, and T-STAI scales after the treatments were significantly lower than those before the treatments (p<0.001), indicating that the patient's anxiety and depression were relieved. For the physiological results, compared with the baseline level, the patient's prefrontal EMG decreased, EEG alpha waves increased, and EEG beta and theta waves decreased after the biofeedback therapy.Conclusion:Our findings suggest that Biofeedback therapy is effective to relieve insomnia symptoms for insomnia patients. The potential mechanism of the biofeedback therapy might be that the therapy relaxes the patients’ mind (reflected by the alpha wave) and muscles (reflected by EMG), and reduces alertness states (reflected by Beta wave), which finally promotes the deep sleep (reflected by the Theta wave).
Clinical correlation with metabolic changes post cholecystectomy
Authors: FARRUGIA ALEXIA , Williams Nigel , Khan Saboor , Arasaradnam Ramesh P 
Published: March 2023

Abstract
Introduction
Bile acid diarrhoea (BAD) can occur due to disruption to the enterohepatic circulation such as following cholecystectomy. However, the mechanism behind this is as yet unknown. The aim of this study was to determine the rate of post-cholecystectomy diarrhoea and to assess whether FGF19 within the gallbladder was associated with the development of BAD.
Methods
This was a prospective case-control study in which patients were assessed pre- and post- cholecystectomy (study group) and compared with patients also having laparoscopic surgery but not cholecystectomy (control group). Their bowel habits and a GIQLI questionnaire was performed to compare the pre- and post-operative condition of the two groups. Gallbladder tissue sample was tested for FGF19 and PPARα in the study group patients. A subset had serum lipid levels, FGF19 and C4 measurements.
Results
Gallbladder PPAR α was found to have a significant correlation with stool consistency, with the lower the PPARα concentration the higher the Bristol stool chart number (i.e. looser stool). There were no significant correlation when assessing the effect of gallbladder FGF19 concentration on bowel habit, stool consistency, lipid levels, BMI or smoking.
The study group showed a significant increase in triglycerides post-operatively, however there were no changes in cholesterol, HDL and LDL levels. Correlation of the increased triglyceride levels with GIQLI, stool consistency and frequency showed no significant results.
Discussion and conclusion
While there is a general improvement in post operative quality of life, we did not find any direct evidence that FGF19 levels within the gallbladder impact the development of post-cholecystectomy diarrhoea. There was however a significant increase in triglycerides postoperatively. There was also no correlation with PPARα suggesting the observed rise is independent of this pathway. Further work is required particularly relating to the gut microbiome to further investigate this condition.
Predictive value of PET metabolic parameters for occult lymph node metastases in PET/CT defined node-negative patients with advanced epithelial ovarian cancer
Authors: Xue Bing , Wang Xihai 
Published: March 2023

Abstract
Accurate lymph node metastasis (LNM) prediction is crucial for patients with advanced epithelial ovarian cancer (AEOC) since it guides the decisions about lymphadenectomy. Many previous studies showed that occult lymph node metastasis was common in AEOC. The objective of our study is to quantitatively assess the probability of occult lymph node metastasis (OLNM) defined by 18F-Fluorodeoxyglucose (FDG) PET/CT in AEOC and explore relationship between ONNM and PET metabolic parameters. The patients with pathologically confirmed AEOC who underwent PET/CT for preoperative staging at our institute were reviewed. Univariate and multivariate analyses were performed to evaluate the predictive value of PET/CT-related metabolic parameters for OLNM. The result of our study showed metastatic TLG index had a better diagnostic performance than other PET/CT-related metabolic parameters. Two variables were independently and significantly associated with OLNM in multivariate analysis: metastatic TLG index and primary tumor location. The logistic model combining metastatic TLG index and primary tumor location might be a promising tool to effectively predict the individualized possibility of OLNM for AEOC patients.
Urban-Rural Disparities in Mortality due to Respiratory Tuberculosis in China: An Age-Period-Cohort Analysis from 1987 to 2021
Authors: su binbin , Ma Libing , Zhong Panliang , Chen Chen , zheng xiaoying 
Published: March 2023

Abstract
Background

China has a high disease burden of respiratory Tuberculosis (TB) and understanding the long-term trends in respiratory TB deaths and their epidemiological characteristics will assist China in achieving the WHO 2035 goal of ending the worldwide TB pandemic. To guide future respiratory TB preventive and intervention initiatives in China, this study thoroughly analyzed the secular trends of respiratory TB death statistics at a national level.

Methods

The annual estimate of respiratory TB mortality was derived from the National Health Commission (NHC). The trend pattern was detected using Joinpoint regression analysis, and the age-period-cohort model was used to estimate cohort and period effects.

Results

Between 1987 and 2021, China's respiratory TB mortality showed a consistent downward trend. respiratory TB mortality in urban areas decreased by 87% with an AAPC of -5.5% during the whole study period, while rural areas fell by 92% with an AAPC of -6.6%. There was a huge urban-rural disparity in respiratory TB mortality in China, with respiratory TB mortality in rural 2.05 times higher than that of the urban population in 1987, while by 2021 this figure had fallen to 1.32 times. respiratory TB mortality is higher in men than in women, and the relative risk gap has widened over time. Age effects in urban and rural areas presented inconsistent variation characteristics. The peak respiratory TB mortality rate occurs at 70–80 years of age in urban populations, whereas in rural with a peak occurs between 20 and 30 years. Overall, women had a higher mortality rate than men until the age of 25, but after 30 years, men's rates exceeded those of women. The period relative risk of respiratory TB mortality for urban and rural males and females showed a monotonic decreasing trend. And with the posterior shift of birth years, the cohort effect showed a decreasing trend.

Conclusion

There was a significant reduction in respiratory TB deaths between 1987–2021, particularly in rural areas. The risk of TB death is higher among men and rural populations. And the gap between urban and rural areas is widening, while the gender gap is closing. Certain groups such as children and older men need priority for prevention and control policies. The Chinese government should develop timely, effective, and targeted intervention strategies to further reduce respiratory TB mortality and help to achieve global respiratory TB control targets.

Trial registration

Not applicable.
Spatial differentiation of soil nutrients and their ecological chemometrics based on geographic detector in National Agricultural Park of Tangchang, Southwest China
Authors: Liu Jiufen , Gong Cang , Wang Shunxiang , Wang Liang , Tan Changhai , Wen Lang , Lu Haichuan 
Published: March 2023

Abstract
In order to analyze the spatial variability of soil nutrients and their ecological chemometrics in Tangchang Town, National Agricultural Park, 20 influencing factors were selected: soil pH, Cd, Hg, As, Cu, Pb, Cr, Zn, Ni, Se, elevation, slope, aspect, land use type, distance from industrial land, distance from commercial land, distance from railway, distance from residential area, distance from highway and distance from river. The effects of various influencing factors on the spatial variability of total organic carbon (TOC), total nitrogen (N), total phosphorus (P), total potassium (K) and ecological stoichiometry were analyzed by means of geographic detector. The results showed that there were significant differences in the spatial distribution of soil nutrients and their eco-stoichiometry in the study area, and TOC, N, P, K, C/N, C/P, C/K, N/P, N/K and P /K has a significant correlation with each other, and a significant correlation with soil properties. Factor detection showed that soil properties, distance from railway and distance from residential area had the most significant explanatory power to the spatial heterogeneity of soil nutrients and eco-stoichiometry. Interaction detection showed that the interaction between soil properties with other factors was the most important factor affecting the spatial differentiation of soil nutrients and their ecological chemometrics, and elevation, distance from railway and distance from residential area were also important factors. Risk detection showed that the differences of soil nutrients and their ecological stoichiometry were most significant in the subregions of soil properties (pH, Cd, Hg, As, Cu, Pb, Cr, Zn, Ni and Se).
Neuropilin-2 acts a critical determinant for epithelial-to-mesenchymal transition progression and aggressive behaviors of human head and neck cancervia the RSK1/Sox2/Zeb1 signaling pathway
Authors: Ahn Min-Hye , Kim Ji-Hoon , Choi Su-Jung , Kim Hyun-Ji , Park Dong-Guk , Oh Kyu-Young , Yoon Hye-Jung , Hong Seong-Doo , Lee Jae-Il , Shin Ji-Ae , Cho Sung-Dae 
Published: March 2023

Abstract
Background
Neuropilin-2 (NRP2) is a multifunctional single-pass transmembrane receptor that binds to two disparate ligands, namely, vascular endothelial growth factors (VEGFs) and semaphorins (SEMAs). It is reportedly involved in neuronal and vascular development. In this study, we uncovered the exact functional role of NRP2 and its molecular mechanism during aggressive behaviors and lymph node (LN) metastasis in human head and neck cancer (HNC) and identified algal methanol extract as a potential novel NRP2 inhibitor.
Methods In silico
analyses and immunohistochemistry were used to investigate the relationship between NRP2 expression and the prognosis of HNC patients. The functional role of NRP2 on the proliferation, migration, invasion, and cancer stem cell (CSC) properties of HNC cells was examined by MTS, soft agar, clonogenic, transwell migration and invasion assays, and sphere formation assays. Signaling explorer antibody array, western blot, and qPCR were performed toward the investigation of a molecular mechanism that is related to NRP2.
Results
NRP2 was highly expressed in HNC and positively correlated with LN metastasis and advanced tumor stage and size in patients. Using loss- or gain-of-function approaches, we found that NRP2 promoted the proliferative, migratory, and invasive capacities of human HNC cells. Furthermore, NRP2 regulated Sox2 expression to exhibit aggressiveness and CSC properties of human HNC cells. We demonstrated that p90 ribosomal S6 kinase 1 (RSK1) elevates the aggressiveness and CSC properties of human HNC cells, possibly by mediating NRP2 and Sox2. Zeb1 was necessary for executing the NRP2/RSK1/Sox2 signaling pathway during the induction of epithelial-to-mesenchymal transition (EMT) and aggressive behaviors of human HNC cells. Moreover, the methanol extract of Codium fragile (MECF) repressed NRP2 expression, inhibiting the RSK1/Sox2/Zeb1 axis, which contributed to the reduction of aggressive behaviors of human HNC cells.
Conclusions
These findings suggest that NRP2 is a critical determinant in provoking EMT and aggressive behaviors in human HNC through the RSK1/Sox2/Zeb1 axis, and MECF may have the potential to be a novel NRP2 inhibitor for treating metastasis in HNC patients.
Incidence and predictors of mortality among neonates admitted with perinatal asphyxia at west Oromia region referral hospitals, Ethiopia, 2022
Authors: Tesfaye Dawit , Adugna Chalachew , Getaneh Tewodros , Terefe Bewuketu 
Published: March 2023

Abstract

Background Perinatal asphyxia is one of the preventable and treatable causes of neonatal mortality. However it is the fifth largest cause of under-five mortality. There are both long-term and short-term neurodevelopmental consequences of perinatal asphyxia, which can result in disability or even death. Even though management advancements, it remains one of the key public health issues in underdeveloped countries, including Ethiopia. Comorbidities are also understated therefore adequate information regarding the incidence of death and its predictors is required. Methods A four-year retrospective follow-up study was conducted from October 03 to November 02, 2022. From a total sample size, 616 data were collected by nurses reviewing charts using Kobo Toolbox software. Data was exported to STATA Version 14 for analysis. Cox proportional hazard assumption was checked and the model for the data was selected by Akaike Information Criteria. Finally, an adjusted hazard ratio with 95% CI was computed, and variables with a P-value < 0.05 in the multivariable analysis were taken as significant predictors of death. Result The overall incidence of mortality was 38.86/1000 days (95%CI: 33.85–44.60). The median time of follow-up was 15 days (95% CI: 14–20). The proportion of deaths was 202 (32.79%, 95% CI: 29.18–36.61) among neonates with perinatal asphyxia. While distance from health facility > 10 KM is (AHR: 2.25; 95%CI: 1.60–3.17), direct oxygen (AHR = 1.83; 95% CI: 1.35–2.48), APGAR score < 3 at fifth minute (AHR = 2.63; 95% CI: 1.03–6.73), prolonged ROM (AHR = 1.41; 95% CI: 1.02–1.94), and stage III HIE (AHR = 2.02; 95% CI: 1.18–3.47) were a predictors of mortality, among neonates with perinatal asphyxia. Conclusion The study found that, neonatal mortality among perinatal asphyxia remains high. Therefore, in order to reduce neonatal mortality among asphyxiated neonates, reducing prolonged ROM, APGAR score < 3 at fifth minute, using direct oxygen, stage III HIE, and a place of residences more than 10KM away from health facility.
Ab initio calculation for electronic structure and optical property of tungsten carbide in a TiCN-based cermet for solar thermal applications
Authors: Hayakawa Shota , Chono Toshiharu , Watanabe Kosuke , Kawano Shoya , Nakamura Kazuma , Miyazaki Koji 
Published: March 2023

Abstract
We present an ab initio calculation to understand electronic structures and optical properties of a tungsten carbide WC being a major component of a TiCN-based cermet. We found that the WC has a fairly low-energy plasma excitation ~0.6 eV (2 µm) and therefore can be a good constituent of a solar selective absorber. The evaluated figure of merit for photothermal conversion is prominently high compared to those of the other materials included in the TiCN-based cermet. The imaginary part of the dielectric function is considerably small around the zero point of the real part of the dielectric function, corresponding to the plasma excitation energy. Therefore, a clear plasma edge appeared, ensuring the high performance of the WC as the solar absorber.
Age, chronic lung disease, and IgA levels influence the perturbation of respiratory microbial ecosystems in Common Variable Immunodeficiency
Authors: Pulvirenti Federica , Giuffrè Maria , Pentimalli Tancredi M. , Camilli Romina , Milito Cinzia , Villa Annalisa , Cerquetti Marina , Pantosti Annalisa , Quinti Isabella 
Published: March 2023

Abstract
Background
The respiratory tract microbiome is essential for human health and well-being and is determined by genetic, lifestyle, and environmental factors. Patients with Common Variable Immunodeficiency (CVID) suffer from respiratory and intestinal tract infections, leading to chronic diseases and increasing mortality. Alterations in CVID gut microbiota have been extensively analysed, while data on the respiratory microbiome ecosystem are limited.
Methods
The microbiome of oropharyngeal samples from 72 CVID adult patients and 26 age-matched controls were collected in a 12-month prospective study. Samples were analysed by metagenomic bacterial 16S ribosomal RNA sequencing and processed using the Quantitative Insights Into Microbial Ecology pipeline. Differentially abundant species have been identified and used to build a dysbiosis index. Microbiome alterations allowed the distinction between CVID and healthy status using a machine learning model trained on microbial abundance data.
Results
The oropharyngeal microbiome of CVID patients showed lower alpha- and beta-diversity, with a relatively increased abundance of the order Lactobacillales including the family Streptococcaceae. Undetectable serum IgA and COPD were associated with the higher abundance of the genera Haemophilus and Streptococcus, independently from recent antibiotic use. Patients with COPD featured a higher dysbiosis score.
Conclusions
Adult CVID patients showed an altered respiratory microbial ecosystem with enrichment with potentially pathogenic bacteria and decreased potentially protective species. Treatment aimed to replace mucosal IgA and possibly reduce upper respiratory infections by immunobiotics should gain attention.
A Constrained Filter for Indoor Localization Based on Multi-filter Fusion and NLOS Identification
Authors: Wang Yan , Chen Yun 
Published: March 2023

Abstract
Wireless sensor networks (WSN) are increasingly important in various fields. One of the main technologies of WSN is mobile node localization. And how to achieve precise node positioning in non-line-of-sight (NLOS) environments is a main challenge. In this paper, we propose a constrained filter NI-HCF based on NLOS identification and multi-filter fusion. We first process the measurements using Extended H-infinity filter (EHF) to obtain the predicted state vector. Subsequently, NLOS identification is conducted on measurements via residual analysis between predicted state vectors and measurements, categorizing them into LOS and NLOS groups. We send the classified measured values into Constrained Square-Root Unscented Kalman Filter (CSRUKF). This means that the measured value of LOS is processed with Square Root Unscented Kalman Filter (SRUKF). And NLOS measurements are utilized to determine a feasible domain. The sigma points outside the feasible domain can be projected into the feasible domain by solving the Semi-Definite Programming (SDP) problem. The final position estimate is obtained by the projected sigma points. Simulations and experimental tests indicate that the proposed algorithm achieves improved positioning precision in NLOS conditions and has better results compared with MPDA, IMM-EKF, RIMM, EKF and REKF.