bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition and biocontrol potential of Ochrobactrum pseudogrignonense NC1 against four Phytophthora species
Authors: Liu Jinming , Zhang Shiyu , Ma Haikun , Huang Jun , Xiang Meichun , Liu Xingzhong 
Published: June 2023

Abstract
Phytophthora species are highly destructive soilborne oomycetes pathogens that spread through infested soil and water. Ochrobactrum pseudogrignonense NC1 has been shown to inhibit plant parasitic nematodes via volatile organic compounds (VOCs). In this study, we investigated the inhibitory effect of O. pseudogrignonense NC1 against four Phytophthora species on agar plates and in vivo bioassay. We found that NC1 significantly inhibited the mycelial growth and zoospore production of all four species of Phytophthora in a dose-dependent manner. The half maximal inhibitory concentration (IC50) values for inhibition of mycelial growth (or zoospore production) were 26.0% (14.8%), 18.9% (14.2%), 20.3% (8.3%) and 46.9% (4%) for Phytophthora capsici Leonian, Phytophthora infestans, Phytophthora parasitica var. nicotiana and Phytophthora sojae, respectively. The biocontrol efficiency of NC1 was 46.3% in pepper seedlings against P. capsici, almost 100% in potato tubers against P. infestans, 60% in tomato leave against P. parasitica and 100% in soybean leave against P. sojae, respectively. Our findings suggest that O. pseudogrignonense NC1 has great potential as a biocontrol agent for managing Phytophthora diseases.
Bandwidth Enhancement of Micro Strip Patch Antenna for 5G Range Applications
Authors: kolli Venkatrao - , G Merlin Sheeba 
Published: June 2023

Abstract
The journey from 4G to 5G involves in lot many challenges in terms of spectrum sharing to antenna design to handle large bandwidths and work cooperatively. Compatible antenna design requirements include simple geometry, feed system, and scope for mass manufacturing. In this paper, the technique of designing antenna which can operate at 28GHz band has been demonstrated. The basic design is modified several times in terms of the feed line structure and the radiating patch geometry. In every stage the antenna is analyzed in terms of several radiation parameters to understand the radiation characteristics like pattern and gain. On the other hand, it is possible to study the effect of the geometrical non-uniformity along the plane of the feed line on the corresponding gain, pattern and resonant characteristics. The simulations are carried out on the HFSS and the analysis is performed on the simulated plots.
The fire regimes of the Southern Appalachians may radically shift under climate change.
Authors: Robbins Zachary , Loudermilk E. Louise , Mozelewski Tina G. , Jones Kate , Scheller Robert M. 
Published: June 2023

Abstract
Background: Increased drought due to climate change will alter fire regimes in mesic forested landscapes where fuel moisture typically limits fire spread, and where fuel loads are consistently high. These landscapes are often extensively modified by human land use change and management. We forecast the influence of varying climate scenarios on potential shifts in the wildfire regime across the mesic forests of the Southern Appalachians. This area has a long history of fire exclusion, land use change, and an expanding wildland urban interface. We considered interactions among climate, vegetation, and anthropogenic influences to forecast future fire regimes and changes to the forest structure. We used climate scenarios representing divergent drought patterns (overall drought trend and interannual variability) within a process-based fire model that captures the influence of climate, fuels, and fire ignition patterns and suppression.
Results: Compared to simulations using historical climate (1972-2018), future total burned area (2020-2100) increased by 42.3 % under high drought variability, 104.8 % under a substantial increase in drought severity, and 484.7 % when combined. Landscape patterns of fire exclusion and suppression drove the spatial variability of fire return intervals (FRI). Our projections indicate wide spatial variability in future fire regimes with some areas experiencing multiple fires per decade while others experience no fire. More frequent fires corresponded with increased oak prevalence and a reduction in the biomass of mesic hardwoods and maple; however, mesic hardwoods remained prevalent under all fire intervals because of their contemporary dominance.
Conclusions: Our study illustrates how future drought-fire-management interactions and a history of fire exclusion could alter future fire regimes and tree species composition. We find that increasing trends in drought magnitude and variability may increase wildfire activity, particularly in areas with minimal fire suppression. In ecosystems where fuel moisture (and not load) is the standard limitation to fire spread, increased pulses of drought may provide the conditions for more fire activity, regardless of effects on fuel loading. We conclude the effects of climate and human management will determine the novel conditions for both fire regime and ecosystem structure.
Blood donor biobank as a resource in personalized biomedical genetic research
Authors: Clancy Jonna , Ritari Jarmo , Vaittinen Eevaleena , Arvas Mikko , Tammi Silja , FinnGen FinnGen , Koskela Satu , Partanen Jukka 
Published: June 2023

Abstract
Backround
Health questionnaires and donation criteria result to accumulation of highly selected individuals in blood donor population. To understand better the usefulness of blood donor-based biobank in personalised disease-associated genetic studies and for possible personalised blood donation policies we evaluated the occurrence and distributions of common and rare disease-associated genetic variants in Finnish Blood Service Biobank.
Methods
We analysed among 31,880 blood donors the occurrence and geographical distribution of (i) 53 rare Finnish enriched disease-associated variants, (ii) mutations assumed to influence blood donation: four Bernard-Soulier syndrome and two hemochromatosis mutations, (iii) type I diabetes risk genotype HLA-DQ2/DQ8. In addition, we analysed the level of consanguinity in Blood Service Biobank.
Results
80.3% of blood donors carried at least one (range 0–9 per donor) of the rare variants, many in homozygous form as well. Donors carrying multiple rare variants were enriched in the Eastern Finland. Haemochromatosis mutation HFE C282Y homozygosity was 43.8% higher than expected, whereas mutations leading to Bernard-Soulier thrombocytopenia were rare. The frequency of HLA-DQ2/DQ8 genotype was slightly lower than in the general population. First-degree consanguinity was higher in Blood Service Biobank than in the general population.
Conclusion
We demonstrate that despite donor selection the Blood Service Biobank is a valuable resource for personalised medical research and for genotype-selected samples from unaffected individuals. Geographical genetic substructure of Finland enables efficient recruitment of donors carrying rare variants. Furthermore, we show that blood donor biobank material can be utilized for personalized blood donation policies.
Extreme storms can limit the expansion of the invasive species Caulerpa cylindracea in the rocky shore.
Authors: Sanz-Lazaro Carlos , Terradas-Fernández Marc , Casado-Coy Nuria 
Published: June 2023

Abstract
Invasive species constitute a major environmental concern worldwide and extreme events, favoured by climate change, are expected to enhance their invasibility, however more scientific evidence is needed to better understand this interaction. We tested manipulatively in the rocky shore how the invasibility of the alga Caulerpa cylindracea, one of the most deleterious exotic species worldwide, was affected as storms become more extreme. We found that low intensity storms with a high frequency enhanced the invasibility of C. cylindracea, while extreme storms, limited the invasibility of this alga. These effects did not only occur on the short-term, but also after several months after the disturbance, suggesting legacy effects. C. cylindracea having a low attachment capacity is expected to need other canopy-forming algae to facilitate its attachment to the substrate, while large bare rock patches may leave C. cylindracea too exposed to the wave effect on rocky shores hindering its survival in this habitat. This study suggests that extreme events do not necessarily enhance the invasibility of exotic species and can have contrasting effects depending on the habitat. Thus, the effects of extreme events on the invasibility of exotic species needs to be particularly studied in different habitats, so optimized management strategies can be adapted to each habitat in pursuit to mitigate as much as possible the effects of climate change.
Nitrate Reductase Drives Nutrition Control and Disease Resistance in Tomato (Solanum lycopersicum L.) Cultivars
Authors: Xu Huilian , Kong Mengmeng , Ali Qurban , Jing Hairong , Wang Fuli , Xu Qicong , Li Fenglan , Gu Jinsong , Shen Yu 
Published: June 2023

Abstract
Purpose
Nitrogen plays an important role in plant nutrition. Nitrate reductase can increase the activity can rapidly reduce the accumulation of nitrate in plant tissues and indirectly prevent the occurrence of diseases and insect pests. However, the excess of soluble nitrogen compounds in plants will induce plant diseases and insect pests.
Methods
In this study, the disease-resistant tomato cultivar 'Myko' and its parents were compared with the disease-susceptible tomato cultivar 'Momotaro', and the positive correlation was confirmed between the disease resistance and the enhanced nitrate reductase activity and the up-regulated NR1 (the gene of nitrate reductase).
Results
The expression level of the NR1 gene and the daily average yield of tomato fruit during the growth period were simulated by the modified Gaussian curve equation (y = YMe−α(x−τ)^2+YB (1 + βt)). Compared with Momotaro, Myoko F1 was less prone to disease and maintained relatively high photosynthetic capacity and fruit producing potential in the later stages, which showed that the above-average daily fruit yield and NR1 gene expression shifted rightward in the Gaussian curve. The high activity of nitrate reductase, and concentration as well as amino acids in Myoko F1 is much lower as compared to Momotaro.
Conclusions
In summary, the analysis of nitrate reductase genes and the mathematical models adopted indicate that the increase in nitrate reductase activity can promote nitrogen metabolism, reduce the accumulation of nitrate and amino acids in tomato leaves and fruits, and thus reduce the occurrence of tomato early leaf blight.
Disparities and Equity Dashboards in the Neonatal Intensive Care Unit: A Qualitative Study of Expert Perspectives
Authors: Razdan Sheila , Hedli Laura , Sigurdson Krista , Profit Jochen , Morton Christine 
Published: June 2023

Abstract
Objective:
Racial/ethnic disparities are well-described in the neonatal intensive care unit (NICU). We explore expert opinion on their root causes, potential solutions, and the ability of health equity dashboards to meaningfully address NICU disparities.
Study Design:
We conducted 12 qualitative semi-structured interviews, purposively selecting a diverse group of neonatal experts. We used grounded theory to develop codes, shape interviews, and conduct analysis.
Result:
Participants identified three sources of disparity: interpersonal bias, care process barriers, and social determinants of health, particularly as they affect parental engagement in the NICU. Proposed solutions included racial/cultural concordance, bolstering hospital-based resources, and policy interventions. Health equity dashboards were viewed as useful but limited because clinical metrics do not account for many of the aforementioned sources of disparities.
Conclusion:
Equity dashboards serve as a motivational starting point for quality improvement; future iterations may require novel, qualitative data sources to identify underlying etiologies of NICU disparities.
A realist review of power dynamics in the implementation of intersectoral collaborative health programmes and policies in LMICs: Protocol
Authors: Aivalli Praveenkumar , Dada Sara , Gilmore Brynne , Srini Prashanth Nuggehalli , De Brún Aoife 
Published: June 2023

Abstract
Introduction:
Intersectoral Collaboration (ISC) is increasingly recognised as a critical aspect of global health and an important prerequisite for developing integrated public health policies. However, in practice, ISC has proven challenging due to its complexity. While studies have documented factors that have facilitated ISC (like shared vision, leadership and clear delineation of sectoral roles) and those that have hindered ISC (including resource constraints, competing priorities and a lack of accountability), there is a limited understanding of the role of power on collaboration effectiveness while implementing ISC interventions. Thus, the present review is expected to bridge this knowledge gap by synthesising evidence from the literature on exploring how, why, for whom, under what circumstances and to what extent power dynamics between different sectors influence the collaboration while implementation of intersectoral health programmes and policies in Low and Middle-Income Countries (LMICs).
Method and analysis:
A realist review will be conducted to explain the role of power dynamics in the implementation of intersectoral policies through following a number of iterative steps: (1) Eliciting initial programme theories by engaging key experts for input and feedback, (2) Performing systematic and purposive searches for grey and peer-reviewed literature on Medline, Embase, CINAHL and Web of Science databases along with Google Scholar (3) Selecting appropriate documents while considering rigour and relevance, (4) Extracting data, (5) Synthesising data and (6) Refining the initial programme theory into a middle range realist theory. By generating Context-Mechanism-Outcome (CMO) configurations, this review seeks to understand how power dynamics between different sectors influence the implementation of intersectoral health programmes and policies and explore the mechanisms that trigger specific outcomes (implementation success or failure) in LMICs.
Discussion:
Given the complex nature of power dynamics in ISCs, realist philosophy is well suited to address the aim of this study. The findings from this review (refined programme theory) will be tested through case studies of the national nutrition mission in Assam, India, which uses an ISC approach to implement nutrition interventions. The outcomes of this synthesis are also expected to guide the implementation of other ISC approaches in similar settings.
Prophylactic versus Preemptive Modified Donor Lymphocyte Infusion for High-risk Acute Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: A Multicenter Retrospective Study
Authors: Yang Lu , Lai Xiaoyu , Yang Ting , Lu Ying , Liu Lizhen , Shi Jimin , Zhao Yanmin , Wu Yibo , Chen Yi , Yu Jian , Xiao Haowen , Ouyang Guifang , Ren jinhua , Cao Junjie , Hu Yongxian , Tan Yamin , Ye Yishan , Cai Zhen , Xu Weiqun , Huang He , Luo Yi 
Published: June 2023

Abstract
Donor lymphocyte infusion (DLI) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been widely used in preventing post-transplant relapse. We performed an intent-to-treat analysis to compare the clinical outcomes and superiority of prophylactic modified DLI (pro-DLI) and preemptive modified DLI (pre-DLI) in patients with high-risk relapse features acute leukemia. Pro-DLI was performed in 95 patients, whereas the pre-DLI cohort included 219 patients. Thirty-eight patients in the pre-DLI cohort became MRD positive and received pre-DLI. Pro-DLI cohort had lower 3-year cumulative incidence of relapse (CIR, 25.3% versus 38.0%, P = 0.01) and nonsignificant trend toward survival benefit (overall survival (OS), 65.2% versus 58.4%, P = 0.24; progression-free-survival (PFS), 63.4% versus 53.7%, P = 0.05). Multivariable analysis demonstrated a strong protective effect of pro-DLI on OS (hazard ratio (HR) = 0.62, P = 0.03), PFS (HR = 0.54, P = 0.003) and CIR (HR = 0.45, P = 0.001). Subgroup analysis of patients who received allo-HSCT at first complete remission (CR1) indicated that pro-DLI achieved lower 3-year CIR, higher non-relapse mortality (NRM), and no benefit on survival. In patients who received HSCT beyond CR1, pro-DLI significantly decreased CIR without increasing NRM and improved survival. Pro-DLI can be recommended for patients with high-risk features who received allo-HSCT beyond CR1 while pre-DLI could be chosen by those who transplanted in CR1.
Adverse event profile differences between Trastuzumab Emtansine and Trastuzumab Deruxtecan: a real-world, pharmacovigilance study
Authors: Liu Fen , Yin Guisen , Xue Shuyi , Rehman Faisal UL , Liao Dehua , Pan Yong 
Published: June 2023

Abstract
Introduction:
Trastuzumab emtansine(T-DM1) and trastuzumab deruxtecan (T-DXd, formerly DS-8201a), the human epidermal growth factor receptor 2 (HER-2)-targeted antibody-drug conjugate (ADC), are commonly used in metastatic breast cancer. However, their real-world safety profile has not been adequately compared.
Objective
We aimed to investigate the adverse event (AE) profile of T-DM1 and T-DXd reported by the US Food and Drug Administration Adverse Event Reporting System (FAERS).
Methods
All indications were searched for T-DM1 and T-DXd, as primary suspected drugs from FAERS data (December 2014 to December 2022). Disproportionality analyses were performed by reporting odds ratios (ROR). The AE with a total number of reports less than five or a lower limit of 95% confidence intervals (95% CI) of ROR less than one were excluded to avoid false positives༎
Results
6333 and 2032 reports of T-DM1 and T-DXd were submitted to FAERS. Finally, 171 and 42 significant signals for T-DM1 and T-DXd were systematically analyzed. The highest frequency and strongest signal of AE were neuropathy peripheral (4.90%) and hepatopulmonary syndrome (ROR = 487.34) for T-DM1, nausea (15.99%) and interstitial lung disease (ROR = 82.33) for T-DXd. Disproportionality analyses on the SOCs between T-DM1 and T-DXd were performed. T-DM1 occurred more frequently in cardiac disorders (ROR = 13.98), eye disorders (ROR = 3.88), hepatobiliary disorders (ROR = 1.42), infections and infestations (ROR = 1.32), investigations (ROR = 1.67), musculoskeletal and connective tissue disorders (ROR = 4.72), nervous system disorders (ROR = 4.61), skin and subcutaneous tissue disorders (ROR = 1.82), psychiatric disorders (ROR = 9.34) and vascular disorders (ROR = 6.38). While T-DXd occurred more frequently in blood and lymphatic system disorders, gastrointestinal disorders, administration site general condition disorders, metabolism and nutrition disorders, and respiratory, thoracic, and mediastinal disorders.
Conclusions
Significant differences in the AE profile between T-DM1 and T-DXd have been systematically described and analyzed, from which we recommend more attention should be paid to hematotoxicity, gastrointestinal toxicity, and ILD or pneumonia for T-DXd and thrombocytopenia, hepatobiliary disorder and peripheral neuropathy for T-DM1.
Therapeutic efficacy of Xingnaojing injection for ischemic stroke: A systematic review and meta-analysis of randomized controlled trials
Authors: Xiao Falin , Xue Jin , Huang Shiyu , Lai Yingyao , Zhu Weifeng , Zuo Zhengyun , Chen Lihua 
Published: June 2023

Abstract
Background
Stroke is one of the leading causes of human disability and death, and ischemic stroke constitutes 69.6–70.8% of all strokes. Xingnaojing injection (XNJ) is used to treat stroke in China, but its specific mechanism is not completely clear. This meta-analysis evaluated the clinical efficacy and safety of XNJ for ischemic stroke treatment and showed that XNJ could inhibit the inflammatory response of stroke patients.
Methods
Nine databases were searched from inception to 20 July 2021, following the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) criteria for systematic reviews and meta-analyses. Two reviewers independently screened studies, extracted data of interest, and assessed the risk of bias. Meta-regression and subgroup analysis evaluated the heterogeneity and its impact on the results.
Results
In total, 24 separate RCTs, which were all conducted in China and published from 2008 to 2021, involved 2522 patients with ischemic stroke. XNJ combined with CT were better than CT alone in overall response rate (RR = 1.15, 95%CI [1.12, 1.19], p = 0.00), NIHSS score (WMD=-3.38, 95%CI [-4.35, -2.40], p = 0.00), Barthel index (WMD = 8.19, 95%CI [5.70, 10.68], p = 0.00), TNF-α (SMD=-2.75, 95%CI [-3.67, -1.84], p = 0.00), IL-6 (SMD=-2.56, 95%CI [-3.34, -1.70], p = 0.00), and CRP (SMD=-1.30, 95%CI [-1.58, -1.01], p = 0.00). Meta-analysis of safety showed that the data were not statistically significant (p = 0.21). For adverse events with low certainty evidence, safety needs further verification.
Conclusions
Based on the results, XNJ combined with CT likely improved clinical symptoms compared with CT alone. The mechanism may be related to the neuroprotective and anti-inflammatory effects. More high-quality, multicenter, and large-sample RCTs should be tested and verified in the future.
Detection of Target Frequency from Multichannel SSVEP Based BCI System using combined approach of BSS-CCA
Authors: Ojha Mukesh Kumar , Sharma Rishi Raj , Mukul Manoj Kumar 
Published: June 2023

Abstract
This paper demonstrate the combined approach of Blind Source Separation (BSS) and canonical correlation analysis (CCA) to detect the frequency component of Steady state Visual evoked Potential (SSVEP) based Brain computer Interface (BCI) system from non-invasive recorded electroencephalography (EEG) signal. Detection of SSVEP frequency component with great accuracy is most challenging and difficult task for the development of SSVEP based BCI system. Canonical correlation analysis (CCA) is the most widely and rigorously employed method to detect the SSVEP frequency component from multichannel recorded EEG signal. But the presence of spontaneous EEG signal and artifacts that often occurs during the recording of scalp-based EEG signal may deteriorate the detection accuracy of SSVEP frequency component from recorded EEG signal. This work investigates the blind source separation (BSS) as preprocessing technique to decorrelate the source signal (SSVEP) from the recorded, mixed-signal (EEG) to improve the detection accuracy of SSVEP based BCI Inference system. In this paper, the author proposes second-order AMUSE-based BSS algorithms as preprocessing methods for multichannel EEG signals. The CCA technique employs the preprocessed signal to detect the SSVEP frequency components from the recorded EEG signal. The obtained finding indicates that the proposed BSS-CCA method significantly improved the SSVEP detection accuracy as compared to the standard CCA method. In addition to this, the author has also reported that selection of stimulus frequency also plays a vital role in order to improve the detection accuracy of SSVEP BCI system. The obtained result indicate that average detection is much more improved using when stimulus frequency is the range of alpha band (8Hz – 16Hz) as compared to stimulus frequency beyond alpha band (above 16Hz) using both CCA and BSS-CCA approach.