bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mismatch repair factor Mlh1-Pms1 uses ATP to compact and remodel DNA
Authors: Collingwood Bryce W. , Bhalkar Amruta N. , Manhart Carol M. 
Published: January 2025

ABSTRACTIn eukaryotes, mismatch repair begins withMutS homolog (MSH) complexes, which scan newly replicated DNA for mismatches. Upon mismatch detection, MSH complexes recruit the PCNA- stimulated endonuclease Mlh1-Pms1/PMS2 (yeast/human), which nicks the DNA to allow downstream proteins to remove the mismatch. Past work has shown that although Mlh1-Pms1 is an ATPase and this activity is importantin vivo, ATP is not required to nick DNA. Our data, using yeast as a model, suggests that Mlh1-Pms1 forms oligomeric complexes that drive DNA conformational rearrangements using the protein’s ATPase activity. Experiments with non-B-form DNA structures, common in microsatellite regions, show that these structures inhibit Mlh1-Pms1’s activities, likely through impeding Mlh1-Pms1-dependent DNA conformational changes. This could explain an additional mode for instability in these regions of the genome. These findings highlight the importance of DNA compaction and topological rearrangements in Mlh1-Pms1’s function and provide insight into how mismatch repair relies on DNA structure to coordinate events.GRAPHICAL ABSTRACT
Environmental, Developmental, and Genetic Conditions Shaping Monarch Butterfly Migration Behavior
Authors: Tsai Hsiang-Yu , Molina Cristian , Pleasants John , Kronforst Marcus R. 
Published: January 2025

AbstractMonarch butterflies in North America migrate south each autumn, but the mechanisms that initiate their migratory flight remain incompletely understood. We investigated environmental, developmental, and genetic factors that contribute to directional flight by testing summer and autumn-generation monarchs in three flight simulators: two at ground level (with and without wind blockage) and a novel balloon-based system that raised butterflies 30 meters into the air. Monarchs reared under autumn-like conditions in a growth chamber during the summer were also tested to explore the influence of developmental cues. Autumn generation monarchs demonstrated significant southwestern flight orientation, observed exclusively in the balloon simulator, underscoring the importance of high-altitude flight for migratory behavior. Summer generation monarchs reared under autumn-like conditions displayed southward orientation, larger wing sizes, and partial reproductive diapause, indicating specific seasonal environmental cues that are sufficient to induce migratory traits. In contrast, a lab line of monarchs reared in captivity since 2016 exhibited diminished wing size and reduced orientation ability, even when raised outdoors in the autumn, consistent with a loss of migratory traits in the absence of migration. Surprisingly, butterflies in the balloon simulator tended to orient upwind, which suggests that wind may also serves as a directional cue during migration. These findings highlight the critical roles of altitude, wind, and environmental cues in monarch migration and validate the balloon flight simulator as a powerful tool for studying migratory behavior. This research advances our understanding of the initiation of monarch migration and informs strategies for conservation efforts amidst environmental change.
An extended thermal pressure equation of state for sodium fluoride
Authors: Clough Lewis A. , Funnell Nicholas P. , Ridley Christopher J. , Daisenberger Dominik , Hriljac Joseph A. , Lozinšek Matic , Angel Ross J. , Parsons Simon 
Published: January 2025

The effect of pressure and temperature on the unit-cell volume of NaF has been measured by X-ray powder diffraction at ambient pressure between 12 and 300 K and neutron powder diffraction up to 5 GPa between 140 and 350 K. These data have been combined with high-pressure volume data at 300 and 950 K to 25 GPa and adiabatic bulk modulus data to 650 K to define an equation of state for NaF relating molar volume to both temperature and pressure. The model combines a fourth-order Birch–Murnaghan equation of state at 295 K with a Mie–Grüneisen–Debye model for thermal pressure. The parameters of the model set at 295 K and ambient pressure are as follows: reference unit-cell volume V
0 = 14.9724 (5) cm3 mol−1, isothermal bulk modulus K
0T
= 46.79 (14) GPa, first derivative of the bulk modulus K′0T
= 5.72 (12), second derivative of the bulk modulus K′′0T
= −0.43 (4) GPa−1, Debye temperature T
MGD = 459 (3) K, and Anderson Grüneisen parameters γ0 = 1.547 (11) and q = 0.94 (18).
An analysis of literacy differences related to the identification and dissemination of misinformation in Japan
Authors: Yamaguchi Shinichi , Oshima Hidetaka , Watanabe Tomoaki , Osaka Yukiko , Tanihara Tsukasa , Inoue Eri , Tanabe Shinnosuke 
Published: January 2025

Purpose
This study aims to examine the relationship between various types of literacy on one hand and identification of misinformation and dissemination of such information on the other, in search for better countermeasures against misinformation.

Design/methodology/approach
Based on data from a large-scale survey, models are constructed and analyzed to assess the relationships of literacy with both the identification of inaccuracies and dissemination behavior.

Findings
Regarding the identification of misinformation, individuals with high critical thinking attitudes (subjective literacy) are less likely to recognize misinformation, while other objective literacies do not have a significant relationship. Regarding dissemination behavior, individuals with high information literacy, media literacy and critical thinking scores tend not to disseminate misinformation, whereas those with high critical thinking attitudes are more likely to disseminate such information.

Originality/value
First, it quantitatively elucidates the relationships various literacies have with the accuracy judgment and dissemination behavior of misinformation. This highlights the effectiveness of objective indicators of literacies and the need for caution regarding subjective literacy – i.e. self-confidence in their own literacy. Second, it provides a cross-disciplinary analysis of the relationships, covering not only oft-studied politics and health care but also various other fields, thereby identifying comprehensive literacy strategies against misinformation. Third, it addresses differences in dissemination methods and offers insights into more practical countermeasures.
Contemporary value of historical business culture: the role of merchant guild culture in firm internationalization
Authors: Huang Jianbo , Su Hengyi , Wu Hanqi 
Published: January 2025

PurposeMerchant guild culture derives from business practices associated with medieval and early modern merchant guilds. This study aims to investigate the nexus between merchant guild culture and firm internationalization as well as the factors that moderate this nexus.Design/methodology/approachBased on the distribution of the ten merchant guilds in China and data on Chinese listed companies, this study uses the geographical proximity-based method to measure the intensity of merchant guild culture, which is the nearest distance between the ten merchant guilds’ origins and each firm’s registered address.FindingsThis study provides robust evidence that merchant guild culture positively relates to the degree of firm internationalization. It also documents that this nexus is stronger for firms with overseas background executives and those situated in highly marketized regions.Practical implicationsThe findings of this study have valuable implications for both governments and firms. Governments can leverage local cultures to promote the internationalization of domestic firms, particularly in emerging economies with rich cultural heritage. Firms can further enhance their internationalization efforts by hiring more executives with overseas backgrounds.Originality/valueThis study advances the imprinting literature, provides a novel perspective on the antecedents of firm internationalization and expands research on the contemporary value of historical business culture.
Karma-related influences on moral obligation and empathy: an ethical perspective
Authors: Duong Cong Doanh , Pham Dan Khanh , Ngo Thi Viet Nga , Tran Nhat Minh , Dao Van Thanh 
Published: January 2025

PurposeThis study aims to explore how the three dimensions of karma – karmic duty orientation, indifference to rewards and equanimity – influence empathy and moral obligation, with implications for social economics.Design/methodology/approachThe research was conducted on a valid sample of 401 university students in Vietnam, using hierarchical regression to test formulated hypotheses.FindingsThe analysis reveals that karmic duty orientation and indifference to rewards significantly enhance empathy and moral obligation, indicating that individuals with a strong sense of moral duty and intrinsic motivation are more likely to engage in ethical and pro-social behaviors. Equanimity was not found to impact empathy or moral obligation significantly.Practical implicationsOrganizations and policymakers should focus on cultivating moral duties, intrinsic motivations and resilience in ethical behavior to promote social responsibility and sustainability and ensure long-term social and economic stability.Originality/valueThis study contributes to social economics by integrating ethical dimensions of karma into the analysis of moral behavior, offering a fresh perspective that challenges traditional economic models centered on self-interest. The research provides a comprehensive framework for understanding how moral principles influence economic decisions and social outcomes.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-07-2023-0571
Beyond the farm gate: addressing labour and human right issues occurring downstream in the textiles and apparel value chain
Authors: Boersma Martijn , Mellick Zoe , Payne Alice , Coneybeer Justine , Maguire Rowena , O'Brien Erin , Rissanen Timo 
Published: January 2025

PurposeOur research seeks to understand how actors in the Australian cotton industry can address downstream labour and human rights risks in the textiles and apparel value chain.Design/methodology/approachTaking the Australian cotton industry as the site of our action research project, we conducted a qualitative thematic analysis of 19 interviews, supplemented by industry engagement and desktop research.FindingsWe identify seven opportunities for action by the Australian cotton industry to address downstream labour and human rights risks, which are articulated in the context of a strategic enforcement approach.Originality/valueThe research focuses on opportunities for action to address downstream labour and human rights risks, thereby going beyond the traditional interventions by fashion brands and retailers that target upstream actors.
Patent value evaluation based on Bayesian optimized XGBoost model
Authors: Gao Panjun , Qi Yong , Zhao Hongye , Li Xing 
Published: January 2025

PurposeThe purpose of this study is to address the critical need for patent value evaluation within patent management, particularly in the context of the digital economy. Recognizing the importance of utilizing historical data, this research aims to uncover effective methodologies that enhance the appraisal of patent value, which is vital for informed decision-making in the management of scientific and technological advancements.Design/methodology/approachThis study introduces a comprehensive evaluation model by analyzing various factors that influence patent value. An index system is constructed that integrates technical, economic and legal aspects to facilitate a nuanced assessment of patents. The methodological core of this research is the development of an XGBoost patent value appraisal model, which incorporates Bayesian optimization to refine the evaluation process. The model’s validity is tested through empirical analysis of patents in the rapidly evolving sector of cloud computing.FindingsThe empirical results demonstrate that the XGBoost model, strengthened by Bayesian optimization, outperforms traditional categorization techniques. The proposed model shows superior performance in terms of accuracy, precision, recall rate and operational feasibility. These findings indicate a significant improvement in the precision of patent potential and value assessments, leading to more reliable and actionable insights for patent management.Originality/valueThis study introduces a novel patent evaluation model that combines XGBoost with Bayesian optimization. XGBoost enhances performance by integrating weak learners, ideal for complex, nonlinear problems like patent valuation. Bayesian optimization refines hyperparameters efficiently using prior distributions and known results. Its practical implications for patent management and technology exploration are substantial, offering a new tool for strategic decision-making.
The evolution of the content of the “right to work” for refugees within the contemporary international human rights system
Authors: ElBatrawy Farah 
Published: January 2025

PurposeWith the multiple crises unfolding worldwide, the number of refugees has been increasing. One of the fundamental rights central to the well-being and protection of refugees is the “right to work,” and this paper aims to investigate how the right to work for refugees evolved from an international normative perspective.Design/methodology/approachThe paper employs a legal analysis approach in examining the texts of selected legal and policy instruments around the “right to work” to analyse how this right has evolved but with a specific emphasis on the three elements of decent work”: (1) access to the labour market, (2) conditions of work and (3) social protection.FindingsThe paper finds that the elements of decent work have been more or less tackled within the different instruments under review; however, they are almost never in the same clause that relates to the right to work. Social protection is always stated in different standalone clauses. There has also been a shift throughout the instruments in the role of the host states, with a softer language on the responsibilities host states should assume.Originality/valueThe study contributes to the literature on refugee rights by showing how each of the elements of decent work has evolved through the different legal and policy instruments, contributing to a stronger interpretation of the right to work for refugees as the right to decent work.
Information sharing in agri-food supply chains: insights from the Kenya dairy supply chain
Authors: Obonyo Edwin , Formentini Marco , Ndiritu S. Wagura 
Published: January 2025

Purpose
The purpose of this paper is to explore information sharing (IS) in triadic supply chain relationships through social capital lenses in the Kenyan dairy supply chain context, a setting challenged by the need to increase transparency and improve supply chain performance.

Design/methodology/approach
The study used a multiple-case study design. Data was collected using a range of methods, including semi-structured interviews. Six cases with a triadic unit of analysis were identified and analyzed within the Kenya dairy supply chain.

Findings
The study finds that IS and the presence of social capital hinge on the type of triad and the size of the involved suppliers. The study discovers different outcomes of IS on the development of social capital, highlighting the challenges for buyers to develop social capital with second-tier suppliers, while it may be beneficial for horizontal relationships between first-tier suppliers.

Originality/value
This study contributes to extant literature on IS in supply chains by exploring different types of triadic relationships in dairy supply chains in an emerging country context. The type of triad is an antecedent of information, providing a unique and novel insight. Furthermore, the study highlights distinct contextual characteristics of Africa that can influence the IS process.
Business process improvements using SERVQUAL, FMEA and text-mining methods for processing the voice of customer
Authors: Ghifari Zakka Hammadi , Astanti Ririn Diar 
Published: January 2025

PurposeThis study proposes a new framework for business process improvement (BPI) by identifying areas of improvement based on customer complaints.Design/methodology/approachThe proposed framework comprises several stages. The first stage captures the voice of customer (VoC) in the form of customer complaints. The complaints are processed using text mining and sentiment analysis. Negative sentiments indicate areas for improvement by matching words with SERVQUAL dimensions. The FMEA method is used to identify business processes that need to be improved.FindingsThe opposing quality dimensions of SERVQUAL can be incorporated into a database for later identifying consumer complaints. FMEA can be used to identify potential failures in aspects that correspond to consumer complaints; therefore, improvement areas can be identified. The proposed framework, applied to a garment manufacturer, shows that the SERVQUAL dimensions, which were originally intended for service companies, can be adapted to manage customer complaints to support BPI in manufacturing companies.Practical implicationsThe framework can be used by either the manufacturing or service industries to handle customer complaints and use the complaint analysis results to identify improvement areas to avoid the same complaints occurring in the future.Originality/valueIn this study, the construction of a database based on the SERVQUAL dimension to match sentiment results, where negative sentiment indicates improvement, and the use of FMEA to indicate specific business processes that should be improved is novel and has not yet been proposed by previous studies.
Optimizing diesel engine performance and emissions with heated high-pressure fuel lines: an experimental study
Authors: Shashidhara Vijay Vailaya , Prabhu Ravikantha , Nayak Vignesh , Gonsalves Joseph , Murugesh Varun 
Published: January 2025

Purpose
This study aims to propose and evaluate a simpler technology to reduce harmful emissions from diesel engines by preheating the fuel before injection into the combustion chamber.

Design/methodology/approach
A spring-type heater coil with suitable insulation was installed on the high-pressure fuel pipeline to preheat the fuel. Experiments were conducted at a standard injection timing of 23° before top dead center, across 25%, 50%, 75% and 100% of full load. The fuel was preheated to 100°C, 160°C and 220°C for each engine load. Engine performance, emissions and thermal balance were analyzed for preheated and unheated diesel.

Findings
This study found that preheated fuel improved combustion characteristics, with higher pressure rise and net heat release rates during diffusion combustion. Brake thermal efficiency increased by 8.75% to 10.58%, and brake-specific fuel consumption decreased by up to 9.18%. Emissions significantly dropped: nitrogen oxides by up to 51%, smoke density by up to 63%, carbon monoxide by up to 67% and hydrocarbon by up to 25%. Thermal balance results showed increased useful work and reduced heat losses, particularly at higher preheating temperatures.

Originality/value
This research presents a novel and simpler approach to enhancing diesel engine performance and reducing emissions by preheating the fuel. The findings demonstrate significant improvements in efficiency and substantial reductions in harmful emissions, highlighting the potential of preheated fuel as a viable solution for cleaner diesel engine operation.
Clinical characteristics of bullous pemphigoid patients of different ages and the possible mechanism
Authors: Chen Xinyi , Zhang Bingjie , Mao Xuming , Wang Yiman , Yang Yuyan , Liu Yangchun , Chen Fangyuan , Li Li 
Published: January 2025

AbstractBullous pemphigoid (BP) is an acquired autoimmune bullous disease that often occurs in elderly patients. Some BP patients with early age of disease onset were observed to have difficulty in receiving applicable disease control. It remains challenging for clinicians to choose the appropriate treatment for these patients. This study aimed to analyze the differences between patients of different ages at disease onset and further explore the possible mechanism of these differences between patients of different ages. A total of 215 BP patients seen at the dermatology department of Peking Union Medical College Hospital between January 2009 and September 2020 were included. The patients were allocated to five groups according to the age at disease onset. Clinical data were collected through medical records and telephone follow‐up interviews. Analyses of anti‐BP180 antibody subclasses, anti‐BP230 antibodies, complement fixation, serum cytokine levels, and single nucleotide polymorphisms (SNPs) were conducted. Nearly 52% of patients under 60 were misdiagnosed on their first visit, often presenting with oral mucosal involvement. The anti‐BP180 immunoglobulin (Ig) E titers and C3 deposition increased in patients under 60 (p = 0.044 and p = 0.014, respectively), while the anti‐BP230 IgG titers decreased (p = 0.043). The hospitalization rate of patients under 50 was significantly higher than that of patients aged 80 and older (p < 0.001). The patients under 60 had a significantly higher serum concentration of interleukin (IL)‐13, tumor necrosis factor (TNF)‐α, and interferon gamma (IFN‐γ) (p < 0.005, respectively). We observed significant differences in the distribution of genotypes or alleles of TNF‐α rs1799964, TNF‐α rs1800630, and IFN‐γ rs2069705. Approximately one‐third of the elderly patients suffered from neurological diseases. Elderly patients usually presented with peripheral eosinophilia (p = 0.013). No significant difference was identified in the recurrence rate and complement‐activating capacity among the age groups. In conclusion, the early age of BP onset was associated with a more severe clinical presentation, higher titers of anti‐BP180 IgE, lower titers of anti‐BP230 IgG, and significantly higher serum concentrations of IL‐13, TNF‐α, and IFN‐γ. It may also be associated with the presence of SNPs of cytokines, including TNF‐α rs1799964, TNF‐α rs1800630, and IFN‐γ rs2069705 variants.