bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatoblastoma in an elderly woman: A case report simulating a pancreatic neuroendocrine tumour with emphasis on cytomorphological features
Authors: Saoud Carla , Wu Annie A. , Fishman Elliot K. , Hruban Ralph H. , Ali Syed Z. 
Published: December 2022

AbstractPancreatoblastoma (PB), a rare malignant epithelial neoplasm, is the most common pancreatic neoplasm of childhood. It is exceptionally rare in the adult population and its occurrence is limited to case reports. Although the neoplastic cells of PB can have a number of different directions of differentiation, PB is defined by the combination of neoplastic cells with acinar differentiation and squamoid morules. We report a case of a female patient in her 70s who presented with elevated creatinine level, concerning a kidney disorder, and was found to have an abdominal mass on CT scan. Fine needle aspiration (FNA) showed cellular smears with numerous 3‐dimentional clusters of acinar cells and scattered squamoid morules. A cell block showed sheets of cells, some of which formed acini. Numerous squamoid morules were noted and were highlighted by nuclear labelling with antibodies to B‐catenin in the cell block. The FNA diagnosis was rendered as “carcinoma with acinar differentiation, favour pancreatoblastoma.” Subsequent histological findings confirmed the PB diagnosis. Next generation sequencing detected a CTNNB1 mutation. Given the wide usage of FNA in the preoperative diagnosis of pancreatic masses, the cytopathologist needs to be aware of the morphological features of PB and its cytological differential diagnosis, even in an elderly patient. The differential diagnosis includes acinar cell carcinoma, pancreatic neuroendocrine tumour, and solid pseudopapillary neoplasm. In conclusion, the cytological finding of neoplastic cells with acinar differentiation combined with squamous morules and/or mesenchymal elements in the smears and more commonly in the cell blocks appears to be the most specific finding for the diagnosis of PB.
Selective responding to human ostensive communication is an early developing capacity of domestic dogs
Authors: Byosiere Sarah‐Elizabeth , Mundry Roger , Range Friederike , Virányi Zsófia 
Published: December 2022

AbstractOstensive communication, communication motivated not only by an informative intention, but also by an intention to make this informative intention overt, is thought to be restricted to human signalers and to rely on metacognitive skills. On the receiver side, human infants and dogs have been found to selectively respond to human ostensive communication, even if it remains unclear whether they are able to discern the underlying intentions. At present only animals with extensive experiences with humans have demonstrated a response to human attention calling, suggesting that this sensitivity may be an exaptation of communicative skills allowing for context‐specific responding to intraspecific signals. We investigated whether dogs could respond to subtle cues of ostension without clear attention‐calling and how this skill varies across age and with different human‐given signals. Using a two‐way object choice task, we evaluated whether dogs of different ages followed, with their gaze and with their choices, ostensive human pointing and gaze more than a formally similar but non‐ostensive gesture and a directional gaze cue. Dogs followed pointing more than gaze, and older dogs followed the directional cues more accurately than younger dogs. Independent of cue type, we found that dogs of all ages responded to human ostensive signals more than similar directional cues motivated by no communicative intention. Given that dogs are sensitive to subtle cues of ostensive communication from an early age, and that this does not appear to change with age, we suggest that living close to humans may have selected for this skill.Research HighlightsLike human infants, dogs followed human ostensive cues more than non‐ostensive cues both by their approach behavior and their differential looking behavior.Dogs differentiated between ostensive and non‐ostensive human cues from an early age on, without their attention having been called explicitly in advance.Dogs followed human‐given pointing cues more than human‐given gaze cues, independent of age or intention (ostensive or non‐ostensive).The early developing sensitivity of dogs to human ostension suggests that living close to humans may have selected for this skill.
On Problematic Situations and Problematizations: Study Practices and the Pragmatics of a World to‐Be‐Made
Authors: Schildermans Hans 
Published: December 2022

AbstractIn this article, Hans Schildermans suggests practices of study as a way for universities to respond to socio‐ecological questions, issues, and problems related to the Anthropocene. He elaborates the concept of study practices by drawing on traditional pragmatic notions, such as problematic situation and problematization, as these are articulated in John Dewey's theory of inquiry. Prompted by concerns about the closed problem–solution nexus, as well as questions concerning the (egological) worldview underlying this theory, Schildermans aims to reread these ideas through the lens of contemporary authors such as Isabelle Stengers. In doing so, he articulates the educational dynamics of practices of study that address problematic situations, with specific attention to matters of educational futurity. In other words, centrally important to this analysis is the question of how these practices of study participate in a world in‐the‐making by activating possible futures — or, to formulate it somewhat differently, how practices of study give shape to a pragmatics of a world to‐be‐made
Behavioral responses of two small‐sized rodents, Phyllotis vaccarum and Abrothrix andina, to energy challenges of high‐altitude habitats in the Andes Mountains
Authors: Ruperto Emmanuel Fabián , Menéndez Josefina , Taraborelli Paula Andrea , Scattolón Federico Omar , Sassi Paola Lorena 
Published: December 2022

AbstractIn mountain environments, both temperature and food availability vary strongly with altitude, leading to a major challenge to the thermo‐energetic balance of organisms. In this sense, the behavioral repertoire is crucial for animals' adequacy because it implies a short‐term response in the face of environmental changes. In this paper, we explored the behavioral versatility of Phyllotis vaccarum and Abrothrix andina (Rodentia: Cricetidae), two of the mammal species with the highest altitudinal distribution worldwide. By radiotelemetry, we analyzed the activity pattern, home range, and microhabitat selection in populations of both species inhabiting at 2300 and 3100 m altitude in the Central Andes of Argentina. We found that A. andina was diurnal at 3100 m and cathemeral at 2300 m a.s.l., while P. vaccarum was nocturnal at both elevations. Moreover, home range size was larger in A. andina males at 3100 m in contrast to females at identical altitude and males at 2300 m; while, in P. vaccarum, there were no differences according to altitude or sex. Furthermore, we recorded a complex and species‐specific microhabitat selection pattern at different altitudes. Finally, the magnitude of behavioral variability was higher in A. andina than in P. vaccarum for all the traits analyzed. These results are discussed with emphasis on the impact of behavioral traits and their plasticity for species adequacy in high‐altitude environments.
Valorization of different landrace and commercial sorghum (Sorghum bicolor (L.) Moench) straw varieties by anaerobic digestion
Authors: de la Lama‐Calvente David , Fernández‐Rodríguez María José , Gandullo Jacinto , Desena Irene , de la Osa Clara , Feria Ana Belén , Jiménez‐Rodríguez Antonia , Borja Rafael 
Published: December 2022

AbstractTo reduce the impact on the environment and enhance the sustainability of resources, it is necessary to promote and strengthen the use of landrace cultivars that advocate regenerative agriculture. In this study, the growth and development as well as the anaerobic digestion (AD) of six different landrace cultivars, two commercial hybrids cultivars and a public genotype of Sorghum bicolor have been evaluated. The landrace cultivars, in general, presented greater heights, biomass yields and compactness shoots as well as similar or an improvement in grain production compare to the commercial varieties. The AD of the different sorghum straws was performed in batch mode at mesophilic temperature (35°C). The landrace cultivar Zahina (ZH) obtained the highest final methane yield (413 ± 79 NL CH4 kg−1 VS, volatile solids) but the landrace cultivars Zahina gigante (ZHG) and Trigomillo (TG) were the ones that obtained the highest methane per biomass production (13.7 and 12.7 NL CH4 shoot unit−1, respectively). By contrast, the commercial varieties were the ones that obtained the lowest methane yields. Two mathematical models, first‐order kinetics and the Transference Function model, were used to fit the experimental data with the aim of describing and simulating the anaerobic biodegradation of these S. bicolor straw varieties and obtaining the kinetic constants. Both models allowed for adequately fitting the experimental results of methane production with time. In particular, the fastest biomethanization occurred using the commercial variety PR88Y20 (PR88) (specific rate constant k = 0.148 ± 0.008 days−1), while the slowest one was obtained from Panizo (PAN) variety (k = 0.064 ± 0.005 days−1). In addition, the highest values of the maximum methane production rate, Rm, were attained for the varieties ZH and PR88, which were 87.1% and 71.3% higher than that achieved for the PAN variety, which exhibited the lowest value.
A novel, fixed‐dose calcipotriol and betamethasone dipropionate cream for the topical treatment of plaque psoriasis: Direct and indirect evidence from phase 3 trials discussed at the 30thEADV Congress 2021
Authors: Pinter Andreas , Gold Linda Stein , Reich Adam , Green Lawrence J. , Praestegaard Morten , Selmer Johan , Armstrong April W. , Danø Anne , Dhawan Sunil , Galván Jordi , Stallknecht Sandra E. , Trebbien Paw , Augustin Matthias 
Published: December 2022

AbstractFour posters about the novel, fixed‐dose calcipotriol and betamethasone dipropionate cream (CAL/BDP cream) based on Poly‐Aphron Dispersion (PAD) Technology were presented at the 30th European Academy of Dermatology and Venereology (EADV) Congress 2021 and are summarized here. CAL/BDP cream was compared in two randomized, phase 3 trials to vehicle and active comparator (CAL/BDP gel/topical suspension [TS]) in adults with plaque psoriasis (NCT03802344 and NCT03308799). Pooled data from both trials demonstrated significant greater efficacy in favour of CAL/BDP cream for all efficacy endpoints, including PGA treatment success, mPASI, and mPASI75 compared to CAL/BDP gel/TS. CAL/BDP cream was well tolerated and comparable to CAL/BDP gel/TS with no adverse drug reactions with a frequency >1%. In the NCT03308799 study, CAL/BDP cream demonstrated a substantial improvement in the proportion of participants achieving a minimum 4‐point improvement on the peak pruritus numeric rating scale (NRS) score compared with vehicle at Weeks 1, 4 and 8. CAL/BDP cream also improved quality of life (QoL), as assessed through the Dermatology Life Quality Index (DLQI), and the EQ‐VAS at Week 8 compared with active comparator. Treatment convenience of CAL/BDP cream, as measured by the Psoriasis Treatment Convenience Scale, was superior to CAL/BDP gel/TS at all studied timepoints, including questions addressing formulation's greasiness and overall treatment satisfaction. Finally, an indirect comparison following the Bucher's method of adjusted indirect comparison and the difference‐in‐differences method was conducted to compare CAL/BDP cream and CAL/BDP foam, as both therapies have been compared to CAL/BDP gel/TS. Indirect evidence showed that treatment with CAL/BDP cream was associated with a trend for greater QoL improvement than CAL/BDP foam when DLQI improvement was assessed at the recommended treatment duration of 8 weeks for CAL/BDP cream and 4 weeks for CAL/BDP foam. CAL/BDP cream was statistically superior versus CAL/BDP foam in four out of five treatment satisfaction domains.
Tomato detection based on convolutional neural network for robotic application
Authors: Liu Shihui , Zhai Binliang , Zhang Jiantao , Yang Leping , Wang Jiaze , Huang Ke , Liu Mingyue 
Published: December 2022

AbstractThe development of agricultural robots and the promotion of agricultural production automation are important means to alleviate the shortage of agricultural labor. Fruit and vegetable detection is a prerequisite for accurate harvesting by robots. It directly determines the efficiency and quality of harvesting operations. In order to meet the requirements of target positioning and recognition of tomato harvesting robots, this paper studies tomato recognition technology based on YOLOv3 convolutional neural network algorithm. And the tomato detection process of the YOLOv3 model is presented. The YOLOv3 model training dataset is constructed based on greenhouse tomato plants. The test results show that the model based on the YOLOv3 convolutional neural network has a better detection effect.
Provider knowledge, beliefs, and self‐efficacy to deprescribe opioids and sedative‐hypnotics
Authors: Gray Shelly L. , Fornaro Rachyl , Turner Justin , Boudreau Denise M. , Wellman Robert , Tannenbaum Cara , Marcum Zachary A. , Balderson Benjamin , Cook Andrea , Jacobsen Anna Liss , Phelan Elizabeth A. 
Published: December 2022

AbstractBackgroundWhile many studies have assessed and measured patient attitudes toward deprescribing, less quantitative research has addressed the provider perspective. We thus sought to describe provider knowledge, beliefs, and self‐efficacy to deprescribe, with a focus on opioids and sedative‐hypnotics.MethodsAn electronic anonymous survey was distributed to primary care providers at Kaiser Permanente Washington. Two reminder emails were sent. The survey included 10 questions on general deprescribing, and six questions each specific to opioid and sedative‐hypnotic deprescribing. Knowledge questions used a multiple‐choice response option format. Questions addressing beliefs and self‐efficacy (i.e., confidence) used a 0–10 Likert scale. Scales were dichotomized at ≥7 to define agreement (belief questions) or confidence (self‐efficacy questions). We calculated descriptive statistics to summarize the responses.ResultsOf 370 eligible primary care providers, 95 (26%) completed the survey. For general deprescribing questions, a majority believed that lack of patient willingness, withdrawal symptoms and fear of symptom return, and time constraints impeded deprescribing. Approximately half chose the correct answers about opioid deprescribing, 21% were confident that they could alleviate patient concerns about opioid tapering, and 32% were confident managing chronic non‐cancer pain without opioids. For sedative‐hypnotics, 64%–87% of respondents correctly answered questions about risks and the relative effectiveness of alternatives, but only one‐third correctly answered a question about sedative‐hypnotic tapering. Roughly half were confident in their ability to successfully engage patients in sedative deprescribing conversations and select alternatives. Only 54% and 34% were confident in writing a tapering protocol for opioids and sedative‐hypnotics, respectively.ConclusionResults suggest that raising provider awareness of patient willingness to deprescribe, addressing knowledge gaps, and increasing self‐efficacy for deprescribing are important targets for improving deprescribing. Support for writing tapering protocols and prescribing evidence‐based drug and non‐drug alternatives may be important to improve care.
Inflation Expectations, Inflation Target Credibility, and the COVID‐19 Pandemic: Evidence from Germany
Authors: COLEMAN WINNIE , NAUTZ DIETER 
Published: December 2022

AbstractUsing the exact wording of the European Central Bank's definition of price stability, we started a representative online survey of German citizens in January 2019 that is designed to measure long‐term inflation expectations and the credibility of the inflation target. Our results indicate that credibility has decreased in our sample period, particularly in the course of the deep recession implied by the Covid‐19 pandemic. Interestingly, even though inflation rates in Germany have been clearly below 2% for several years, credibility has declined mainly because Germans increasingly expect that inflation will be much higher than 2% over the medium term. We investigate how inflation expectations and the impact of the pandemic depend on personal characteristics including age, gender, education, and political attitude.
Optimizing the vaginal microbiome as a potential strategy to reduce heterosexual HIV transmission
Authors: Armstrong Eric , Kaul Rupert , Cohen Craig R. 
Published: December 2022

AbstractBacterial vaginosis (BV) is a proinflammatory genital condition characterized by high vaginal bacterial diversity and a paucity of Lactobacillus species. BV has been linked to an elevated risk of HIV acquisition among HIV‐negative women and of forward HIV transmission to male sex partners among women living with HIV (adjusted hazard ratios of 1.69 and 3.17, respectively), potentially by eliciting genital inflammation in women with BV and their male sex partners. BV is also highly prevalent among women in sub‐Saharan Africa, suggesting that BV treatment may have potential as an HIV prevention strategy. BV is typically treated with antibiotics but recurrence rates are high, possibly because treatment does not directly promote Lactobacillus growth. More recently, BV treatment strategies incorporating live biotherapeutic lactobacilli have led to sustained optimization of the vaginal microbiome and a decrease in inflammatory biomarkers previously associated with HIV susceptibility. Future studies are urgently needed to evaluate BV treatment strategies that can optimize the vaginal microbiome in the long term through colonization with H2O2‐producing vaginal lactobacilli and to assess whether vaginal microbiota optimization is able to reduce the risk of HIV transmission.
PETROLEUM SYSTEMS ANALYSIS OF THE EASTERN ARABIAN PLATE: CHEMOMETRICS BASED ON A REVIEW OF THE GEOCHEMICAL CHARACTERISTICS OF OILS IN JURASSIC – CENOZOIC RESERVOIRS
Authors: Baniasad Alireza , Littke Ralf , Abeed Qusay 
Published: December 2022

This paper presents the results of an integrated geochemical study of oils in Jurassic – Cenozoic reservoirs in the eastern region of the Arabian Plate. The main objective was to analyze the active petroleum systems at a regional scale across the study area which extends from NE Iraq to SE Oman and includes the entire Persian Gulf. The dataset for the study consisted of more than 500 crude oil samples from 112 oil fields and 11 different reservoir units. This dataset was compiled from both the literature and re‐evaluated geochemical and stable isotope analyses, augmented by new analytical studies.The study documents regional variations and trends in the bulk and molecular properties and stable isotope ratios of the oil samples. Two overall clans and twelve genetic oil families and sub‐families were distinguished using multivariate statistical analysis (chemometrics) based on biomarker parameters. The age, lithology, depositional setting and organic matter type of the respective source rocks for each family/sub‐family was inferred from oil geochemical fingerprints.The results provide insights into the key geological factors that control the number, size and geochemical character of oil fields in the eastern Arabian Plate. The geographical extent of the various oil families was assessed and used to evaluate charge access and to predict migration directions and migration pathways in the study area.The results indicate the value of implementing multivariate statistical analysis on “big data” along with state‐of‐the‐art geological petroleum systems analysis and interpretation of biomarker and oil composition data to investigate complex and extended petroleum systems.
Dysphagia treatments in Parkinson's disease: A systematic review and meta‐analysis
Authors: Cheng Ivy , Sasegbon Ayodele , Hamdy Shaheen 
Published: December 2022

AbstractBackgroundThe majority of patients with Parkinson's disease (PD) develop oropharyngeal dysphagia during the course of their disease. However, the efficacy of dysphagia treatments for these patients remains controversial. Therefore, we conducted this systematic review and meta‐analysis to evaluate treatment efficacy based on the evidence from randomized controlled trials (RCTs).MethodsFive electronic databases were systematically searched from inception date to April 2022. Two reviewers independently extracted and analyzed the data. The outcome measures were changes in swallowing‐related characteristics based on instrumental swallowing assessments.Key ResultsAn initial search identified 187 RCT studies of relevance. After screening, nine studies with a total sample size of 286 were included in the meta‐analysis. The pooled effect size for all dysphagia treatments compared with control comparators was significant and medium (SMD [95% CI] = 0.58 [0.22, 0.94],p = 0.001;I2 = 50%). Subgroup analysis revealed a significant and medium pooled effect size for stimulation treatments (brain stimulation, peripheral neurostimulation and acupuncture) (SMD [95% CI] = 0.54 [0.15, 0.92];p = 0.006;I2 = 22%). Specifically, the effect sizes for the single RCTs on neuromuscular stimulation (SMD [95% CI] = 1.58 [0.49, 2.86];p = 0.005) and acupuncture (SMD [95% CI] = 0.82 [0.27, 1.37];p = 0.003) were significant and large.Conclusions and InferencesOur results showed that overall, dysphagia treatments, particularly stimulation treatments, can potentially benefit PD patients. However, given the limited number of small RCTs for each type of treatment, the evidence remains weak and uncertain. Further large‐scale, multicenter RCTs are warranted to fully explore their clinical efficacy in the PD population.