bluuebunny/crossref_metadata_2025_split huggingface dataset:
Walter Pater and Non-Darwinian Science
Authors: Kistler Jordan 
Published: January 2023

Abstract
Walter Pater’s engagement with nineteenth-century science has long been acknowledged, but critics have often characterized it in negative terms. This essay demonstrates that while Pater viewed Darwinian evolutionary theory negatively, insisting that it ‘stealthily withdraws the apparently solid earth itself from beneath one’s feet’ (Plato and Platonism, 1893), he embraced non-Darwinian theories of development. Peter J. Bowler has argued that an ‘eclipse of Darwinism’ or ‘non-Darwinian revolution’ took place in the second half of the nineteenth century, in which there was widespread public acceptance of the transmutation of species but not of the mechanism of adaptation and natural selection proposed by Darwin. Instead, as Bowler demonstrates, the prevailing understanding of evolution was of a non-Darwinian variety that emphasized form over function and design over random chance. I suggest that within these theories, such as the transcendental morphology propounded by Richard Owen, Pater finds a physical manifestation of his own particular philosophic blend of materialism and idealism. Viewed through this lens, many of Pater’s theories in art and philosophy become clearer, such as his belief in the ‘limitations’ of sculpture, discussed in Studies in the History of the Renaissance. Instead of viewing this as a denigration of sculpture as the art form furthest from the ideal, this essay demonstrates that Pater viewed sculpture in terms of the archetype of transcendental morphology: something both material and immaterial, simple and yet also ideal. Far from retreating from the spectre of contemporary science, as many critics suggest Pater does, Pater views science and the humanities as complementary disciplines, or homologues, sharing an underlying structure.
OsTKPR2 is part of a sporopollenin-producing metabolon required for exine formation in rice
Authors: Yang Huiting , Liu Feng , Wang Wang , Rui Qingchen , Li Ge , Tan Xiaoyun , Ye Jie , Shen Haodong , Liu Yanping , Liu Wenlong , Tang Rong , Hu Jingru , Liu Kai , Zhang Yunhui , Zhan Huadong , Wang Yihua , Bao Yiqun 
Published: January 2023

AbstractThe sporopollenin polymer is a major component of the pollen exine. Fatty acid derivatives synthesized in the tapetum are among the precursors of sporopollenin. Progress has been made to understand sporopollenin metabolism in rice; however, the underlying molecular mechanisms remain elusive. We found that OsTKPR2 and OsTKPR1 share a similar expression pattern, and their coding proteins have a similar subcellular localization and enzyme activities towards reduced tetraketide α-pyrone and hydroxylated tetraketide α-pyrone. Unexpectedly, OsTKPR1pro:OsTKPR2-eGFP could not rescue the phenotype of ostkpr1-4. Three independent ostkpr2 mutant lines generated by CRISPR/Cas9 displayed reduced male fertility to various extents which were correlated with the severity of gene disruptions. Notably, the anther cuticle, Ubisch bodies, and pollen development were affected in the ostkpr2-1 mutant, where a thinner pollen exine was noticed. OsTKPR1 and OsTKPR2 were integrated into a metabolon including OsACOS12 and OsPKS2, which resulted in a significant increased enzymatic efficiency when both OsTKPR1 and OsTKPR2 were present, indicating the mutual dependence of OsTKPR2 and OsTKPR1 for their full biochemical activities. Thus, our results demonstrated that OsTKPR2 is required for anther and pollen development where an OsTKPR2-containing metabolon is functional during rice sporopollenin synthesis. Furthermore, the cooperation and possible functional divergence between OsTKPR2 and OsTKPR1 is also discussed.
Association between Serum α-Klotho Levels and Behçet Disease
Authors: Jafari Nakhjavani Mohammad Reza , Ghorbanihaghjo Amir , Malek Mahdavi Aida , Nemati Negin , Rashtchizadeh Nadereh , Abedi Azar Sima , Khabbazi Alireza 
Published: January 2023

Abstract

Background
Endothelial dysfunction (ED) has a well-known role in promoting vascular inflammation in Behçet disease (BD). α-klotho is involved in regulation of endothelial function, and its reduction has been reported to be associated with ED.

Objective
To assess serum α-klotho in patients with BD, compared with healthy control individuals.

Methods
In a cross-sectional study, 55 patients with BD and 30 age- and sex-matched healthy controls were enrolled, and their serum levels of α-klotho were measured.

Results
Common clinical symptoms in patients with BD were oral aphthous ulcers, uveitis, and genital ulcers. Median (IQR) serum α-klotho levels in the BD and control groups were 0.30 (0.20–0.70) and 1.00 (0.70–2.52) ng/mL, respectively. The difference was statistically significant (P = .005). No significant correlation was observed between serum α-klotho and age (r = 0.194; P = .14). Serum α-klotho levels in patients with uveitis were significantly lower.

Conclusion
α-klotho may have a role in the pathogenesis of ED and is a potential biomarker for uveitis in BD.
Increases in CLIA-Waived Testing Sites Since the Start of the COVID-19 Pandemic
Authors: Xia Yang , Anderson Nancy 
Published: January 2023

AbstractThe number of testing sites receiving their first Certificate of Waiver (CoW) under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) increased significantly after the start of the COVID-19 pandemic. We compared the first-time CoWs in 2020–2021 to those in 2018–2019. The total number of first-time CoWs during 2020–2021 was more than twice what it was in 2018–2019, corresponding to population testing needs during the COVID-19 pandemic, especially in assisted living facility, pharmacy, physician office, and school/student health service settings. This study highlighted the need to strengthen clinical testing strategies to be better prepared for future public health emergencies.
Influenza Vaccine Effectiveness and Test-Negative Study Design Within the Department of Defense
Authors: Sayers David R , Iskander John K 
Published: January 2023

ABSTRACT
Test-negative observational studies are routinely used to assess vaccine effectiveness. This test method consistently shows lower annual vaccine effectiveness in the highly vaccinated U.S. military compared to the general population. Incorporating other test designs and broader impact measures may better estimate influenza vaccine benefits in highly vaccinated groups.
Reading the tea leaves in the Mbh–M*,sph and Mbh–Re,sph diagrams: dry and gaseous mergers with remnant angular momentum
Authors: Graham Alister W , Sahu Nandini 
Published: January 2023

ABSTRACT
We recently revealed that bulges and elliptical galaxies broadly define distinct, superlinear relations in the (black hole mass, Mbh)–(spheroid stellar mass, M*,sph) diagram or Mbh−M*,sph diagram, with the order-of-magnitude lower Mbh/M*,sph ratios in the elliptical galaxies due to major (disc-destroying, elliptical-building) dry mergers. Here, we present a more nuanced picture. Galaxy mergers, in which the net orbital angular momentum does not cancel, can lead to systems with a rotating disc. This situation can occur with either wet (gas-rich) mergers involving one or two spiral galaxies, e.g. NGC 5128, or dry (relatively gas-poor) collisions involving one or two lenticular galaxies, e.g. NGC 5813. The spheroid and disc masses of the progenitor galaxies and merger remnant dictate the shift in the Mbh−M*,sph and Mbh−Re,sph diagrams. We show how this explains the (previously excluded merger remnant) Sérsic S0 galaxies near the bottom of the elliptical sequence and core-Sérsic S0 galaxies at the top of the bulge sequence, neither of which are faded spiral galaxies. Different evolutionary pathways in the scaling diagrams are discussed. We also introduce two ellicular (ES) galaxy types, explore the location of brightest cluster galaxies and stripped ‘compact elliptical’ galaxies in the Mbh−M*,sph diagram, and present a new merger-built Mbh−M*,sph relation which may prove helpful for studies of nanohertz gravitational waves. This work effectively brings into the fold many systems previously considered outliers with either overly massive or undermassive black holes relative to the near-linear Mbh−M*,sph ‘red sequence’ patched together with select bulges and elliptical galaxies.
Use of time dependent data in Bayesian global 21-cm foreground and signal modelling
Authors: Anstey Dominic , de Lera Acedo Eloy , Handley Will 
Published: January 2023

ABSTRACT
Global 21-cm cosmology aims to investigate the cosmic dawn and epoch of reionization by measuring the sky averaged H i absorption signal, which requires, accurate modelling of, or correction for, the bright radio foregrounds and distortions arising from chromaticity of the antenna beam. We investigate the effect of improving foreground modelling by fitting data sets from many observation times simultaneously in a single Bayesian analysis, fitting for the same parameter set by performing these fits on simulated data. We find that for a hexagonal dipole antenna, this simultaneous fitting produces a significant improvement in the accuracy of the recovered 21-cm signal, relative to fitting a time average of the data. Furthermore, the recovered models of the foreground are also seen to become more accurate by up to a factor of ∼2–3 relative to time averaged fitting. For a less chromatic log spiral antenna, no significant improvement in signal recovery was found by this process. However, the modelling of the foregrounds was still significantly improved. We also investigate extending this technique to fit multiple data sets from different antennas simultaneously for the same parameters. This is also found to improve both 21-cm signal and foreground modelling, to a higher degree than fitting data set from multiple times from the same antenna.
A rapid optical and X-ray timing study of the neutron star X-ray binary Swift J1858.6−0814
Authors: Shahbaz T , Paice J A , Rajwade K M , Veledina A , Gandhi P , Dhillon V S , Marsh T R , Littlefair S , Kennedy M R , Breton R P , Clark. C J 
Published: January 2023

ABSTRACT
We present a rapid timing analysis of optical (HiPERCAM and ULTRACAM) and X-ray (NICER) observations of the X-ray transient Swift J1858.6−0814 during 2018 and 2019. The optical light curves show relatively slow, large amplitude (∼1 mag in gs) ‘blue’ flares (i.e. stronger at shorter wavelengths) on time-scales of ∼minutes as well as fast, small amplitude (∼0.1 mag in gs) ‘red’ flares (i.e. stronger at longer wavelengths) on time-scales of ∼seconds. The ‘blue’ and ‘red’ flares are consistent with X-ray reprocessing and optically thin synchrotron emission, respectively, similar to what is observed in other X-ray binaries. The simultaneous optical versus soft- and hard-band X-ray light curves show time- and energy-dependent correlations. The 2019 March 4 and parts of the June data show a nearly symmetric positive cross-correlations (CCFs) at positive lags consistent with simple X-ray disc reprocessing. The soft- and hard-band CCFs are similar and can be reproduced if disc reprocessing dominates in the optical and one component (disc or synchrotron Comptonization) dominates both the soft and hard X-rays. A part of the 2019 June data shows a very different CCFs. The observed positive correlation at negative lag in the soft band can be reproduced if the optical synchrotron emission is correlated with the hot flow X-ray emission. The observed timing properties are in qualitative agreement with the hybrid inner hot accretion flow model, where the relative role of the different X-ray and optical components that vary during the course of the outburst, as well as on shorter time-scales, govern the shape of the optical/X-ray CCFs.
Preconception paternal alcohol exposure decreases IVF embryo survival and pregnancy success rates in a mouse model
Authors: Roach Alexis N , Zimmel Katherine N , Thomas Kara N , Basel Alison , Bhadsavle Sanat S , Golding Michael C 
Published: January 2023

AbstractIncreasingly, couples struggling with fertility turn to assisted reproductive techniques, including IVF, to have children. Despite the demonstrated influence of periconception male health and lifestyle choices on offspring development, studies examining IVF success rates and child health outcomes remain exclusively focused on maternal factors. Using a physiologically relevant mouse model, we tested the hypothesis that chronic paternal preconception alcohol intake adversely affects IVF success and negatively impacts IVF offspring fetoplacental growth. Using a voluntary, binge-like mouse model, we exposed sexually mature C57BL/6J males to three preconception treatments (0% (Control), 6% EtOH or 10% EtOH) for 6 weeks, isolated and cryopreserved caudal sperm from treated males, and then used these samples to fertilize oocytes before assessing IVF embryo developmental outcomes. We found that preconception paternal alcohol use reduced IVF embryo survival and pregnancy success rates in a dose-dependent manner, with the pregnancy success rate of the 10% EtOH treatment falling to half those of the Controls. Mechanistically, we found that preconception paternal alcohol exposure disrupts embryonic gene expression, including Fgf4 and Egfr, two critical regulators of trophectoderm stem cell growth and placental patterning, with lasting impacts on the histological organization of the late-term placenta. The changes in placental histoarchitecture were accompanied by altered regulation of pathways controlling mitochondrial function, oxidative phosphorylation and some imprinted genes. Our studies indicate that male alcohol use may significantly impede IVF success rates, increasing the couple’s financial burden and emotional stress, and highlights the need to expand prepregnancy messaging to emphasize the reproductive dangers of alcohol use by both parents.
Postoperative Inflammation and Fever After Elective Aortic Valve and Aortic Root Replacement: A Retrospective Cohort Study
Authors: Keijmel Stephan P , Zwartkruis Iris M M , Jongenotter Jochem , Geuzebroek Guillaume S C , Kouijzer Ilse J E 
Published: January 2023

Abstract

Background
Fever after cardiac surgery is common. More knowledge of postoperative fever could lead to better patient selection for diagnostic workup and empirical antibiotic treatment. We aimed to analyze the postoperative course of inflammation and fever after elective aortic valve and aortic root replacement.

Methods
In a retrospective single-center cohort study, we included 3 groups of patients after elective cardiac surgery: aortic root with aortic valve replacement (Bentall procedure, from 2014 to 2021), valve-sparing root replacement (VSRR, from 2014 to 2021), and isolated surgical aortic valve replacement (SAVR, from 2018 to 2021). Exclusion criteria were age &lt;18 years, cardiac surgery other than described, use of deep-hypothermic circulatory arrest, reoperations, and preexisting infections. Primary outcome measure was the number of patients per group with postoperative fever (≥38°C). Secondary outcome measures were the percentage of patients per group with infections and outcome.

Results
Among 307 patients included (76 Bentall, 40 VSRR, 191 SAVR), 71% had postoperative fever. Fever occurred significantly more often in the Bentall (84%) and VSRR group (83%) compared with patients after SAVR (64%, P = .001). Seventeen patients had fever due to infection versus 202 with diagnoses of postoperative inflammation. In case of infection, fever was significantly higher (38.8°C vs 38.4°C, P = .03), and both the number of days with fever and hospital admission duration were significantly longer.

Conclusions
Postoperative fever is more often observed after Bentall procedure and VSRR compared to SAVR. In diagnoses of infection, there is a higher and prolonged fever.
Color-scalable flow cytometry with Raman tags
Authors: Nishiyama Ryo , Hiramatsu Kotaro , Kawamura Shintaro , Dodo Kosuke , Furuya Kei , de Pablo Julia Gala , Takizawa Shigekazu , Min Wei , Sodeoka Mikiko , Goda Keisuke 
Published: January 2023

AbstractFlow cytometry is an indispensable tool in biology and medicine for counting and analyzing cells in large heterogeneous populations. It identifies multiple characteristics of every single cell, typically via fluorescent probes that specifically bind to target molecules on the cell surface or within the cell. However, flow cytometry has a critical limitation: the color barrier. The number of chemical traits that can be simultaneously resolved is typically limited to several due to the spectral overlap between fluorescence signals from different fluorescent probes. Here, we present color-scalable flow cytometry based on coherent Raman flow cytometry with Raman tags to break the color barrier. This is made possible by combining a broadband Fourier-transform coherent anti-Stokes Raman scattering (FT-CARS) flow cytometer, resonance-enhanced cyanine-based Raman tags, and Raman-active dots (Rdots). Specifically, we synthesized 20 cyanine-based Raman tags whose Raman spectra are linearly independent in the fingerprint region (400 to 1,600 cm−1). For highly sensitive detection, we produced Rdots composed of 12 different Raman tags in polymer nanoparticles whose detection limit was as low as 12 nM for a short FT-CARS signal integration time of 420 µs. We performed multiplex flow cytometry of MCF-7 breast cancer cells stained by 12 different Rdots with a high classification accuracy of 98%. Moreover, we demonstrated a large-scale time-course analysis of endocytosis via the multiplex Raman flow cytometer. Our method can theoretically achieve flow cytometry of live cells with &gt;140 colors based on a single excitation laser and a single detector without increasing instrument size, cost, or complexity.
Efficacy and Dose of Rehabilitation Approaches for Severe Upper Limb Impairments and Disability During Early Acute and Subacute Stroke: A Systematic Review
Authors: Doumen Steff , Sorba Luca , Feys Peter , Tedesco Triccas Lisa 
Published: January 2023

AbstractObjectiveThe purpose of this study was to examine the evidence of the efficacy of rehabilitation approaches for improving severe upper limb impairments and disability during acute and early subacute stroke, taking into consideration the dosage of therapy.MethodsRandomized controlled trials from PubMed, Web of Science, and Scopus databases were searched by 2 independent researchers. Studies were selected if they involved active rehabilitation interventions that were conducted in the acute stage (&lt;7 days after stroke) or the early subacute stage (&gt;7 days–3 months after stroke), with the aim of improving severe upper limb motor impairments and disability. Data were extracted on the basis of the type and effect of rehabilitation interventions and on the dosage (duration, frequency, session length, episode difficulty, and intensity). Study quality was assessed using the Physiotherapy Evidence Database Scale.ResultsTwenty-three studies (1271 participants) with fair to good methodological quality were included. Only 3 studies were performed in the acute stage. Regardless of the type of intervention, upper limb rehabilitation was found to be beneficial for severe upper limb impairments and disability. Robotic therapy and functional electrical stimulation were identified as the most popular upper limb interventions; however, only a limited number of studies showed their superiority over a dose-matched control intervention for severe upper limb impairments in the subacute stage. A longer rehabilitation session length (&lt;60 minutes) did not seem to have a larger impact on the magnitude of improved upper limb impairments.ConclusionDifferent rehabilitation approaches seem to improve severe upper limb impairments and disability in the subacute stage after stroke; however, they are not distinctly superior to standard care or other interventions provided at the same dosage.ImpactRobotic therapy and functional electrical stimulation add variety to rehabilitation programs, but their benefit has not been shown to exceed that of standard care. Further research is necessary to identify the impact of dosage parameters (eg, intensity) on severe upper limb motor impairments and function, especially in the acute stage.
Extending time-series models for irregular observational gaps with a moving average structure for astronomical sequences
Authors: Ojeda C , Palma W , Eyheramendy S , Elorrieta F 
Published: January 2023

ABSTRACT
In this study, we introduce a novel moving-average model for analyzing stationary time-series observed irregularly in time. The process is strictly stationary and ergodic under normality and weakly stationary when normality is not assumed. Maximum likelihood (ML) estimation can be efficiently carried out through a Kalman algorithm obtained from the state-space representation of the model. The Kalman algorithm has order O(n) (where n is the number of observations in the sequence), from which it is possible to efficiently generate parameter estimators, linear predictors, and their mean-squared errors. Two procedures were developed for assessing parameter estimation errors: one based on the Hessian of the likelihood function and another one based on the bootstrap method. The behaviour of these estimators was assessed through Monte Carlo experiments. Both methods give accurate estimation performance, even with relatively small number of observations. Moreover, it is shown that for non-Gaussian data, specifically for the Student's t and generalized error distributions, the parameters of the model can be estimated precisely by ML. The proposed model is compared to the continuous autoregressive moving average (MA) models, showing better performance when the MA parameter is negative or close to one. We illustrate the implementation of the proposed model with light curves of variable stars from the OGLE and HIPPARCOS surveys and stochastic objects from Zwicky Transient Facility. The results suggest that the irregular MA model is a suitable alternative for modelling astronomical light curves, particularly when they have negative autocorrelation.