bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEMS-scanning-based image projection simulation
Authors: Bainschab Markus , Baumgart Marcus , Travnik Aleš , Holzmann Dominik , Piot Adrien , Lagosh Anton , Pribošek Jaka 
Published: April 2023

Abstract
The absence of simulation tools to predict image quality significantly complicates the hardware and software development of MEMS scanning-based projection systems. In this work, we present a mathematical and simulational framework to accurately predict the quality of images projected by MEMS-based point-scanning projection systems. The described framework is applied to visualize different kinds of distortions limiting the image quality of scanning-based projection systems. The simulation of beam propagation through the system enables entirely correcting all distortions in the projected image. Finally, simulation results are compared to images projected using a custom-made MEMS scanning-based projection system. The presented results demonstrate the potential of adequate simulation tools for system hardware and software optimization. The presented simulation framework can lay the foundation for systematic studies of scanning-based image formation and the optimization of perceived image quality.
Ultrafast and high-throughput immunoassay test of anti-SARS-CoV-2 IgG antibodies in dogs
Authors: Gonçalves Ana Carolina Aparecida , Conzentino Marcelo , Barbosa Altina Bruna Souza , Doline Fernando Rodrigo , Nilsson Mariana Guimarães , Silva Aristeu Vieira , Kmetiuk Louise Bach , Biondo Alexander Welker , Huergo Luciano Fernandes 
Published: April 2023

Abstract
As SARS-CoV-2 has reportedly infected companion, livestock and wildlife species, animals may play a role as virus reservoirs and reverse zoonosis may become a significant risk. Since these host species may serve as ground for new variants, SARS-CoV-2 surveillance in animal species should be considered as crucial for pandemics prevention. Accordingly, the present study has aimed to validate a high-throughput ultrafast magnetic bead immunoassay to detect anti- SARS-CoV-2 IgG antibodies in dog serum samples. The assay was validated using serum from eleven positive dogs to SARS-CoV-2 by RT-qPCR and 160 pre-pandemic samples, reaching 72.7% to 81.8% sensitivity and 97.5 to 98.1% specificity. Thus, this novel assay has shown adequate performance of anti-SARS-CoV-2 antibodies detection and may be used for surveillance and research purposes.
Psycho-pharmacomicrobiomics: a systematic review and meta-analysis
Authors: Minichino Amedeo , Person Tabitha , Fanshawe Jack , Fusar-Poli Paolo , McGuire Philip , Burnet Philip , Lennox Belinda 
Published: April 2023

Abstract
Understanding the bi-directional interplay between the gut microbiome and the effects of psychotropics medications (“psycho-pharmacomicrobiomics”) could lead to improved treatment stratification and personalised interventions strategies in psychiatry. In this systematic review and meta-analysis, we explored first, whether psychotropic medications modify the gut microbiome, and second, if the gut microbiome affects the efficacy and tolerability of psychotropic drugs.
Following PRISMA guidelines, we searched from inception to November 2022 for longitudinal and cross-sectional studies investigating the effect of psychotropic medications (namely antipsychotic, antidepressants, and mood stabilisers) on the gut microbiome. The primary outcome was the difference in diversity metrics (alpha and beta) before and after treatment with psychotropics (longitudinal studies), and in medicated compared to unmedicated individuals (cross-sectional studies). Secondary outcomes included the association between gut microbiome features (at baseline and changes after treatment) with efficacy and tolerability outcomes. Random effect meta-analyses were conducted on alpha diversity metrics, while beta diversity metrics were pooled using distance data extracted from graphs. Summary statistics included SMD, 95% CI, and Higgins I2 for alpha diversity metrics, F and R values for beta diversity metrics.
Nineteen studies were included in our synthesis; twelve investigated antipsychotics and seven antidepressants. Results showed significant changes in alpha (SMD: 0.12; 95% CI: 0.01 to 0.23; P=0.04; I2: 14%) and beta (F=15.59; R2:0.05; P<0.001) diversity metrics following treatment with antipsychotics and antidepressants, respectively. Altered gut microbiome composition at baseline was associated with tolerability and efficacy outcomes across studies, including response to antidepressants (alpha diversity; SMD: 2.45; 95%CI: 0.50 – 4.40; P<0.001, I2: 0%). Females, but not males, patients treated with antipsychotics showed reduced alpha diversity compared to untreated controls (SMD: -0.68; 95% CI: -1.31 to -0.04; P=0.04; I2: 37.61%).
These findings suggest that: 1. Treatment with psychotropic medications are associated with altered gut microbiome composition; 2. The gut microbiome may influence the efficacy and tolerability of these medications. Further studies using translational approaches to clarify mechanisms and direction of causality are indicated.
A nomogram for predicting lymph node metastasis in early gastric signet ring cell carcinoma
Authors: You Hongwei , Chen Shengsen , Wang Shi 
Published: April 2023

Abstract
Background: At present, the risk factors of lymph node metastasis in early gastric signet ring cell carcinoma (SRCC) are not clear. The lymph node metastasis (LNM) rate and prognosis of early gastric SRCC are better than those of other undifferentiated cancers. With the development of endoscopic technology, the five-year survival rate of endoscopic treatment of early gastric cancer is similar to that of traditional surgery, and its quality of life is better than that of traditional surgery. Therefore, the aim of this study is to develop a nomogram that can predict the SRCC, hoping to help clinicians choose the best treatment strategy.
Methods: The data of 183 patients with early gastric SRCC who underwent radical gastrectomy with lymph node dissection in our hospital from January 2014 to June 2022 were retrospectively collected to establish a research cohort. The least absolute selection and shrinkage operator (Lasso) and multivariate regression analysis were used to identify the predictors of early gastric SRCC lymph node metastasis in the study cohort, and Nomogram was established. The receiver operating characteristic (ROC) curve, calibration curve and decision curve were used to evaluate the discrimination, accuracy and clinical practicability of the nomogram.
Results: The overall incidence of lymph node metastasis was 21.9% (40/183). Multivariate logistic regression analysis showed that tumor size and lymphovascular invasion (LVI) were independent risk factors for lymph node metastasis. Lasso regression analysis showed that tumor size, depth of invasion, LV, E-cad, dMMR, CA242, NLR and macroscopic type were related to LNM. The basic model 1, which included tumor size and LVI, had an area under curve(AUC) of 0.741 for predicting LNM. The addition of depth of invasion to model 1 resulted in significant improvements in AUC (P=0.023) and net reclassification index (NRI) (P < 0.001).The inclusion of dMMR and CA242 also improved NRI (P < 0.001). When type_1 was included, the AUC (P=0.017), Integrated discrimination Improvement (IDI) (P=0.003) and NRI (P=0.032) of the model were significantly improved. Therefore, we finally included tumor size, LVI, depth of invasion, dMMR, CA242 and macroscopic type to establish the nomogram, which showed good discrimination (AUC=0.823, 95%CI: 0.757-0.889) and calibration. Decision curve analysis showed that the nomogram had good clinical performance.
Conclusion: We developed a risk prediction model for lymph node status in early gastric signet ring cell carcinoma, which can be used for patient consultation and treatment decision-making.
Reliability of bioimpedance in the assessment of visceral fat in patients with obesity and metablic syndrome treated with liraglutide for 6 months
Authors: RODRIGUES CARLOS , freitas Frederico carioca 
Published: April 2023

Abstract
BACKGROUND Metabolic syndrome (MS) and obesity represent a public health problem worldwide and are associated with increased risk of type-II diabetes mellitus and cardiovascular disease. Bioimpedance analysis is a practical and effective way of evaluating body composition, especially with regard to abdominal fat. Liraglutide, the first GLP-1 analog approved for treatment of obesity, reduces body weight and improves cardiometabolic parameters.METHODS Prospective study on 103 adult obese patients with MS followed for 6 months. The treatment group (n = 57) received liraglutide at 3 mg/day, while the control group (n = 43) received sibutramine at 15 mg/day. All patients were submitted to bioimpedance analysis, physical examination and lab testing at baseline and at 6 months.RESULTS A greater reduction was observed in the treatment group with regard to fat mass (-10.5 [-14.3; -7.7] vs -7.65 [-10.5; -5.3], p = 0.001) and abdominal circumference (AC) (-13 [-16; -9] vs -6 [-9; -4], p < 0.001). In the bioimpedance analysis, liraglutide was associated with a greater reduction in the fat mass of both arms and the trunk (p < 0.05). AC and truncal fat mass were strongly correlated (rho = 0.531, p < 0.001) in the treatment group.CONCLUSION Treatment with liraglutide at 3 mg/day for 6 months efficiently promoted weight loss and improved bioimpedance, cardiometabolic and inflammatory parameters in obese MS patients. Bioimpedance analysis was found to be a practical and reliable way of quantifying loss of visceral fat in this patient population.
Circulating platelets and malaria severity: Two sides of the same coin among inhabitants of a Tropical Savannah region, Nigeria
Authors: Shittu Olalere , Oniya Mobolanle Oladipo , Olusi Titus Adeniyi 
Published: April 2023

Abstract
Changes in circulating platelets during different grades of malaria is of major concerns and its etiology is poorly understood. We appraised and evaluated the role of circulating platelets in the determination of severity of malaria among a cohort of outpatients living in Ilorin, Nigeria. A hospital-based cross sectional cohort of outpatients visiting public health facilities within the locality voluntarily enrolled for this study. Blood samples from 1,162 malaise patients were screened using routine protocols for Plasmodium parasite species identification, clinical conditions and circulating platelet levels. Seven hundred and seventy five individuals (775, 66.7%, p < 0.001) were malaria-positive. Samples from 387 (33.3%) uninfected healthy individuals were used as controls. Individuals with uncomplicated malaria (UCM) and complicated malaria (CM) across age-group was notable (p < 0.05). Children ≤ 5yrs had the highest number of individuals with CM (103, 45.2%) with relative risk ratio of 4.005 (95% CI: 2.964–5.413). UCM (471, 40.5%) occurred more than CM (304, 26.2%) (p > 0.05) across the groups. The geometric mean, 95% CI, median and IQR of populations with malaria thrombocytopenia were higher (181, 110.94 ± 2.207, 106.59–115.30, 118.00, and 39.00) than thrombocytosis (78, 624.64 ± 13.131, 598.49-650.79, 623.00 and 208). Seemingly, health controls recorded insignificant morbidity with respect to platelet counts. High P. falciparum parasitaemia count is reflective of platelet clump and the manifestation of several malaria pathogenesis. It is expedient to administer antipyretics as a premedication during febrile presentation.
Comprehensive management analysis of 75 deceased donors maintained in ICU: a single center experience
Authors: YAO Zhiyuan , LIU Yu , ZHAN Liying , QIU Tao , LI Guang , CHEN Zhongbao , FANG Xiaoyu , LIU Zhou , WU Wei , LIAO Zhaomin , XIA Wenfang 
Published: April 2023

Abstract
Objective To summarize and analyze the integrated management program of 75 deceased donors maintained in ICU of our hospital, so as to promote the development of organ transplantation.
Methods The data deceased donors maintained in ICU of our hospital from June 2020 to January 2022 were collected. The basic data, laboratory examination results, disease distribution and maintenance measures were retrospectively studied.
Results 75 patients were included, with a sex ratio (M/F) of 90.67% vs 9.33%, a median age of 55, a median ICU length of 4 days. Donors with higher APACHE II scores tended to enter the donation process faster (P=0.001). The primary disease of donors was mainly cerebral hemorrhage (53, 70.67%). 53 pathogens were detected in 58 patients (infection rate: 77.33%), mainly bacteria (42, 79.25%, Gram-negative mainly), Klebsiella pneumoniae, Acinetobacter baumannii and Escherichia coli were the most detected. 96.00% (72/75) donors successfully completed donation, mainly donation after cardiac death (65, 86.67%). 229 large organs and tissues were obtained from 72 donors, with an acquisition ratio of 1:3.14. The acquisition ratio of donors of different ages was statistically different (P<0.001). The overall organ utilization rate was 96.51% (221/229), and the kidney utilization rate in our hospital was 95.14% (137/144).
Conclusion ICU plays an irreplaceable role in organ transplantation. ICU staffs familiarize the integrated management program of deceased donors, which is helpful to promote the development of organ transplantation.
Association between calling and meaning in life among nursing students:the mediation effect of moral identity
Authors: Wang Xiaoxuan , Zhang Zhenxiang , Jiang Hu , Zhao Zhixin , Mei Yongxia , Wang Wenna , Lin Beilei , Chen Suyan 
Published: April 2023

Abstract
Background: Improving meaning in life is beneficial for nursing students to provide better service for patients in the future. As a result, it is important to explore factors affecting meaning in life in nursing students.
Objective: To investigate the mediating role of moral identity in the relationship between calling and meaning in life in nursing students.
Design: This study was a cross-sectional design.
Methods: A total of 10756 nursing students were recruited from November16 to January 17, 2023. The General Demographic Information Questionnaire, the Chinese Calling scale (CCS), the Moral Identity Measure (MIM), and the China Meaning Life Questionnaire (C-MLQ）were used to assess their socio-demographics, calling, moral identity, and meaning in life. Correlation analysis was used to examine the relationship between the three variables. The PROCESS macro was used to conduct mediation analysis. The study was compliant with the STROBE checklist.
Results: The valid questionnaires were 10583 (effective response rate: 98.39%). Most of the participants were female(85.47%),unmarried(98.74%) and rural students(79.09%). High moral identity and high calling were associated with better meaning in life (all P<0.05). Moral identity mediated the relationship between calling and meaning in life. The mediating effect was 65.14% of the total effect(0.454/0.697).
Conclusion: This study contributes to a broader understanding of the factors that influence nursing students' meaning in life. Calling may influence meaning in life, partly through moral identity. Educators can consider enhancing nursing students' meaning in life by increasing their moral identity and calling.
An Infinitary Model of Diagrammatic Calculus in Unbiased Monoidal Categories
Authors: Dheer Vihaan 
Published: April 2023

AbstractProperties of morphisms represented by so-called `string diagrams' of monoidal categories (and their braided and symmetric derivatives), mainly their resistance in value to isotopic deformation, have made the usage of graphical calculi commonplace in category theory ever since the correspondence between diagrams and tensor categories was rigorously established by Joyal and Street in 1991. However, we find it important to make certain additions to the existing theory of monoidal categories and their diagrams, with the goal of extending to so-called `infinitary monoidal categories'. Most crucially, we employ a structure inherently resistant to isotopic deformation, thus replacing topological details with categorical ones. In the process, we coherently introduce infinitary tensor product and transfinite composition into the diagrammatic formalism.
A cross-sectional study of imported malaria infections in Zanzibar
Authors: Fakih Bakar S. , Holzschuh Aurel , Ross Amanda , Stuck Logan , Abdul Ramadhan , Al-Mafazy Abdul-Wahid H. , Irema Imani , Mbena Abdallah , Thawer Sumaiyya G. , Shija Shija J. , Aliy Safia M. , Ali Abdullah , Fink Günther , Yukich Joshua , Hetzel Manuel W. 
Published: April 2023

Abstract
Background Zanzibar has made substantial progress in malaria control with the scaling-up of vector control, improved diagnosis, and artemisinin-based combination therapy. Parasite prevalence in the population has remained around 1% but imported infections from mainland Tanzania contribute to sustained local transmission. Understanding travel patterns between mainland Tanzania and Zanzibar and the risk of malaria infection may help to control the importation of infections to Zanzibar.Methods A rolling cross-sectional survey linked to routine reactive case detection of malaria was carried out in Zanzibar between May 2017 and October 2018. Households of patients diagnosed with malaria at health facilities (‘index cases’) were surveyed and household members were tested for malaria using rapid diagnostic tests and a sub-sample by quantitative PCR (qPCR). Interviews elicited a detailed travel history of all household members who had travelled within the past two months, including trips within and outside of Zanzibar. We estimated the association of malaria infection with travel destinations in pre-defined malaria endemicity categories, trip duration, and other co-variates.Results Of 17,891 survey participants, 1,177 (7%) reported a recent trip, of which 769 (65%) visited mainland Tanzania. Among travellers to mainland Tanzania with travel destination details and a qPCR result available, 64% (241/378) reported traveling to districts with a ‘high’ malaria endemicity and for 12% the highest endemicity category was ‘moderate’. Travelers to the mainland were more likely to be infected with malaria parasites (29%, 108/378) than those traveling within Zanzibar (8%, 16/206) or to other countries (6%, 2/17). Among travellers to mainland Tanzania, those visiting highly endemic districts had a higher odds of being qPCR-positive than those who travelled only to districts where malaria-endemicity was classified as low or very low (aOR = 7.0, 95% CI 1.9–25.5). Among travellers to the mainland, 110/378 (29%) never or only sometimes used a mosquito net during their travel.Conclusions Measures to reduce malaria importation to Zanzibar may benefit from identifying population groups traveling to highly endemic areas in mainland Tanzania. Targeted interventions to prevent and clear infections in these groups may be more feasible than screening and treating of all travellers at the port of entry.
Comparing Methods for Drug-Gene Interaction Prediction on the Biomedical Literature Knowledge Graph: Performance vs. Explainability
Authors: Aisopos Fotis , Paliouras Georgios 
Published: April 2023

Abstract
This paper applies different link prediction methods on a knowledge graphgenerated from biomedical literature, with the aim to compare their ability toidentify unknown drug-gene interactions and explain their predictions. Identifyingnovel drug-target interactions is a crucial step in drug discovery and repurposing.One approach to this problem is to predict missing links between drug and genenodes, in a graph that contains relevant biomedical knowledge. Such a knowledgegraph can be extracted from biomedical literature, using text mining tools. In thiswork, we compare state-of-the-art graph embedding approaches and contextualpath analysis on the interaction prediction task. The comparison reveals atrade-off between predictive accuracy and explainability of predictions. Focusingon explainability, we train a decision tree on model predictions and show how itcan aid the understanding of the prediction process. We further test the methodson a drug repurposing task and validate the predicted interactions againstexternal databases, with very encouraging results.
Analysing home-care services costing by microcosting: A scoping review
Authors: Silva Kênia Lara , Souza Amanda Damasceno , França Bruna Dias , Castro Edna Aparecida Barbosa , Lopes Elaine Silva , Junior Helvo Slomp , Oliveira Jurema , Coelho Karla Santa Cruz , Feuerwerker Laura Camargo Macrus , Rezende Lilian Cristina , Alemão Márcia Mascarenhas , Keulen Maria do Socorro Van , Pereira Paula Bertoluci Alves , Guimarães Rayssa Assunção , Souza Roseli Lino 
Published: April 2023

AbstractObjectiveto map models of Home Care services in the world and the costs associated with them.MethodScope review developed in five stages: identification of the research question; identification of relevant studies; selection of studies; analysis, grouping, synthesis and presentation of data. The search was carried out in seven scientific databases and the gray literature was searched. Texts were included containing a description of the Home Care model/service addressing measures, analyzes or cost comparison, as well as components and cost calculation methods. The texts found were evaluated by two independent researchers for judgment on inclusion. Forty articles that addressed service models and their costs were included and analyzed in depth, in this publication, the eight articles referring to the micro-costing method for calculating costs.ResultThe eight articles, which deal with the micro-costing method in calculating the costs of home care services, were published between 1997 and 2005, one in Spanish and seven in English. The texts deal with two service models: Hospital-at-Home and Home Visit Care. The direct cost components considered were: personnel, medication, inputs, diagnostic and therapeutic tests, transport, equipment depreciation; health care and support services. As indirect and fixed costs, the following were identified: general maintenance, management and administration, hospitality, inpatient units, archives and others, according to hospital cost accounting data. The studies adopt the benchmarks of cost-effectiveness or cost-minimization for economic evaluation. For the cost analysis, the concepts of cost savings and the difference between average cost and cost are used marginally.Conclusionthe concepts of health care costs were mostly approached from the accounting-financial perspective, with calculation of direct, variable or fixed costs. The economic or indirect costs related to the opportunity for HC, costs of family members who care for patients, absenteeism and loss of productivity due to illness are rare and partial in the studies included. This analysis reinforces the need to recognize costs as metadata in the management of health organizations, which means that cost information carries other information.