bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pro-inflammatory response of monocytes in systemic sclerosis
Authors: Kirichenko Tatiana V. , Markin Alexander M. , Gerasimova Elena V. , Popkova Tatiana V. , Markina Yuliya V. , Tolstik Taisiya V. , Bogatyreva Anastasia I. , Orekhov Alexander N. 
Published: June 2023

Abstract
Objective.
The investigation of inflammatory response of immune cells is one of the most actual trends in research of autoimmune disorders including SSc. This study was aimed to investigate the inflammatory cytokines secretion and to evaluate the pro-inflammatory status of blood-derived monocytes in SSc.
Methods.
The study included 35 SSc and 25 heathy participants. Secretion of inflammatory cytokines TNF-α a, IL1β, CCL2 and IL8 was measured by ELISA in primary culture of monocytes/macrophages after stimulation with LPS on day 1 and 6 of incubation to assess the pro-inflammatory activation and immune tolerance of monocytes. Impaired tolerance of immune response is characterized by increased secretion of inflammatory mediators in response to re-stimulation.
Results.
Basal secretion of TNF-α, IL1β, CCL2 and IL8 was significantly higher in SSc patients than in healthy subjects. After the first LPS-stimulation secretion of TNF-α and IL1β, but not CCL2 and IL8 was also higher in SSc group. In 24 hours after re-stimulation, the secretion of IL1β, CCL2 and IL8, but not TNF-α increased significantly in SSc group compared to healthy control. CCL2 secretion by re-stimulated monocytes was 1.8-fold higher than in cells without re-stimulation in SSc group, that was significantly different from healthy subjects.
Conclusion.
The study results demonstrate pro-inflammatory activation and impaired immune tolerance of monocytes in SSc. The violation of immune response in terms of CCL2 may be an important factor of the chronification of inflammation in SSc. Thus, CCL2 should be considered as therapeutic target for the development of immunomodulatory strategies for SSc treatment.
Stability estimates for the expected utility in Bayesian optimal experimental design
Authors: Duong Duc-Lam , Helin Tapio , Rojo-Garcia Jose Rodrigo 
Published: June 2023

Abstract
We study stability properties of the expected utility function in Bayesian optimal experimental design. We provide a framework for this problem in a non-parametric setting and prove a convergence rate of the expected utility with respect to a likelihood perturbation. This rate is uniform over the design space and its sharpness in the general setting is demonstrated by proving a lower bound in a special case. To make the problem more concrete we proceed by considering non-linear Bayesian inverse problems with Gaussian likelihood and prove that the assumptions set out for the general case are satisfied and regain the stability of the expected utility with respect to perturbations to the observation map. Theoretical convergence rates are demonstrated numerically in three different examples.
Partial observation risk-seeking insider trading in continuous time*
Authors: xiao kai 
Published: June 2023

Abstract
In this paper, a continuous-time insider trading model is investigated, we require that
an insider is a risk-seeking and market makers may receive partial signal on risky asset. With
the help of fifiltering theory and dynamic programming principle, the uniqueness and existence of
linear equilibrium is established. It shows that (i) as time goes by, residual information decrease,
but both trading intensity and market liquidity are increasing; (ii) As partial observation precise
increase, both market liquidity and residual information are decreasing, however, the trading
intensity will increase. On the whole, the risk-seeking insider is eager to trade all the trading
period
ASAP: an automatic sequential assignment program for solid state multidimensional NMR spectra
Authors: Chen Bo 
Published: June 2023

Abstract

We describe an automatic sequential assignment program (ASAP) for congested solid state NMR (ssNMR) spectra. Given the residue type assignments determined from the well resolved spectra, ASAP first applies auto-residue type assignment strategy (ARTIST) to group individual resonances in unassigned congested spectra into matched residue type assignments, accounting for all possible combinations. Then matched residue type assignment pairs are sequentially allocated by Monta Carlo simulated annealing (MCSA) algorithm. Analytical expressions are derived for critical steps to achieve optimized annealing, in agreement with direct visualization of assignments migration during annealing, provided by the diagnostic tools in ASAP. We point out that there are three types of local minima associated with mis-allocations of assignments in sequential assignment. Owing to the correlation established by ARTIST between inputs, ASAP demonstrates superior robustness against local minima compared to standard MCSA. Alternative strategies are described for accelerated convergence towards global minima and to avoid local minima. Taken together, the efficiency, accuracy and capability of structural determination by ssNMR can be greatly enhanced by ASAP.
Analysis of the learning curve for Retzius-sparing Robot-assisted radical prostatectomy for a single surgeon
Authors: Hussein Hany , Maitra Neil , Tay June , Saxionis Ioannis , Makin-Taylor Robert , Sivathasan Sailantra , Smart Sonny , Warren Anne , Shah Nimish , Lamb Benjamin Wilfrid 
Published: June 2023

Abstract
Background
The learning curve for retzius sparing robotic radical prostatectomy is not fully understood.
Objective
This study attempts to identify the learning-curve across the first 130 cases of a single surgeon.
Design, Setting, and Participants:
All retzius sparing robotic radical prostatectomy cases performed by a single surgeon at a high-volume tertiary hospital between April 2019 and July 2022 were included.
Outcome Measurements and Statistical Analysis:
Outcome measures included positive surgical margin rate, complication rates and unplanned readmission to hospital, postoperative urinary continence, erectile function, and PSA measurement. Cases were divided chronologically into 3 groups and differences between groups assessed.
Results and Limitation:
130 RS-RARP cases were identified. Differences were found between groups in several areas. Positive surgical margin rate fell between Group 1 (30.2%) and Group 3 (9.1%). Safety, post-operative continence, erectile function and PSA remained stable. Median patient age increased between group 1 (59yrs) and Group 3 (66.5yrs) (P = 0.04). Proportion of patients with stage > T2 increased between Group 1 (27.9%) and Group 2 (41.9%) (P = 0.036). Median console time increased between Group 1 (120 mins) and Group 2 (150 mins,) (P = 0.01). Median gland weight increased between Group 1 (28g) and Group 3 (35.5g) (P < 0.001).
Conclusions
The positive surgical margin rate improved over the learning curve, despite the complexity of cases increasing, reflected in older patients, larger prostates and higher stage disease. Safety and functional outcomes are excellent throughout. The learning curve might be facilitated by careful case selection favouring smaller prostates with less advanced disease.
Patient Summary:
We analysed the learning-curve for Retzius-sparing robotic radical prostatectomy. Across the first 130 cases positive surgical margin rate fell; safety and continence remained excellent. Selection of smaller and less advanced cases may facilitate learning.
Beta diversity of freshwater algal communities: Influence of different dispersal mechanisms
Authors: Cochak Crislaine , Zanon Felipe Morais , Pineda Alfonso , Lansac-Tôha Fernando Miranda , Jati Susicley , Velho Luiz Felipe Machado 
Published: June 2023

Abstract
Although animal vectors facilitate algal dispersal, the specific role of individual vectors in the temporal dynamics of algal community establishment remains unclear. In this study, we investigated the effects of wind and animal vectors, specifically amphibians and odonates, on temporal variation in algal composition and abundance. We conducted a 33-day field experiment in 2018 with four treatments that included different propagule additives. We identified 74 algal species from 11 taxonomic groups, with Chlorophyceae being the most abundant. Species richness and density varied significantly after day 12. Similarity in species composition and density increased over time in all treatments, with more species added at the beginning of the experiment and more species lost at the end. Our results suggest that different vectors had different effects on the local beta-temporal diversity of algal communities. The influence of morphological differences among vectors and the number of dispersal vectors on the variation of beta diversity and community characteristics was observed. We found that dissimilarity changed more rapidly when there were multiple vectors capable of dispersing more individuals and species. The effectiveness of algal dispersal by different animal vectors and its influence on the temporal dynamics of algal communities can vary in different environments and over longer periods of time. Overall, our study highlights the importance of understanding dispersal control and its relationship to the temporal dynamics of algal communities
Upgrade of waste stabilization ponds to improve effluents for reuse purposes
Authors: Sinn Jochen , Agrawal Shelesh , Orschler Laura , Schubert Selina , Lackner Susanne 
Published: June 2023

AbstractWaste stabilization pond (WSP) systems exist in many countries affected by climate change causing increasing demand for irrigation water. There is little long-term experience with WSP in Africa, and thus, this study provides a comprehensive investigation of a WSP in Namibia. One of its treatment trains was upgraded with mechanical and anaerobic pre-treatment, and post-treatment and compared to a second train without upgrades. The pre-treatment showed positive results on COD, TSS and partially pathogen removal. E. coli were reduced to the new EU reuse standard of 1,000 MPN/100 mL for fodder irrigation, P. aeruginosa stagnated and Enterococci levels increased. The main pathogen reduction happened during pre-treatment and in the baffled facultative pond. In contrast, the post-treatment only reduced 5% of algae-based chlorophyll-a. Among the top 20 genera, Pseudomonas was most dominant. With different upgrades, hygiene requirements especially for restricted fodder irrigation can be reached. At the same time, high total tCOD and TN effluent values did not meet different reuse standards. But as the tCOD mainly consists of algae, adding biomass and TN fertilizer to the barren soil, it raised the question if all parameters set in the standards are applicable for WSP or should be adapted to their specific purpose.
Evaluating the impact of projected CO2, temperature, and rainfall change on groundwater resources in a rice–wheat dominated cropping region of northwestern India
Authors: Kumar Satyendra , Nand Viveka , Narjary Bhaskar , Harode Pavan Kumar , Islam Adlul , Yadav R. K. , Kamra S. K. 
Published: June 2023

Abstract

Increasing CO2 concentration, temperature rise, and changes in rainfall due to climate change are expected to influence groundwater resources in irrigated agricultural regions. A simulation study using AquaCrop and MODFLOW models was undertaken to assess the combined effects of increasing CO2 concentrations, temperature, and rainfall changes on groundwater behavior in a rice–wheat cropping region of northwest India. Simulations were carried out for the 2016–2099 period under two scenarios: increasing CO2 concentrations corresponding to different RCPs (Scenario-I) and at a constant CO2 concentration of 369.4 ppm (Scenario-II). The results indicate that elevated CO2 negates the effect of rising temperature on evapotranspiration (ET) and water demand, and thus, lower ET is simulated under Scenario-I than Scenario-II for different RCPs during the future periods. The lower projected ET resulted in lower rice (2.3%–6.3%) and wheat (1.4%–16.1%) irrigation demand under Scenario-I than under Scenario-II. Of all RCPs, the lowest groundwater level (GWL) decline of 9.2, 20.5, and 24.4 m from the reference GWL (18.85 m) at the end of the early, mid-, and end-century periods, respectively, is projected under RCP8.5 and Scenario-I. Simulation results indicate that CO2 concentration plays an important role while assessing climate change effects on groundwater in irrigated agricultural systems.
Polyphenolic Nano-formulations: A New Avenue against Bacterial Infection
Authors: Farhadi Faegheh , Eghbali Samira , Torabi Parizi Sousan , Jamialahmadi Tannaz , Gumpricht Eric , Sahebkar Amirhossein 
Published: June 2023

:
The gradual emergence of new bacterial strains impervious to one or more antibiotics
necessitates discovering and applying natural alternatives. Among natural products,
various polyphenols exhibit antibacterial activity. However, polyphenols with biocompatible
and potent antibacterial characteristics are limited due to low aqueous solubility
and bioavailability; therefore, recent studies are considering new polyphenol formulations.
Nanoformulations of polyphenols, especially metal nanoparticles, are currently being
investigated for their potential antibacterial activity. Nanonization of such products increases
their solubility and helps attain a high surface-to-volume ratio and, therefore, a
higher reactivity of the nanonized products with better remedial potential than nonnanonized
products. Polyphenolic compounds with catechol and pyrogallol moieties efficiently
bond with many metal ions, especially Au and Ag. These synergistic effects exhibit
antibacterial pro-oxidant ROS generation, membrane damage, and biofilm eradication.
This review discusses various nano-delivery systems for considering polyphenols as antibacterial
agents.
Potent Lipophilic Melatoninergic x-fluoro-y-methoxy Substituted Phenylalkylamides:
Molecular Dynamics Calculations and in vitro Modified Release in
Aqueous Media from Tablet Formulations
Authors: Vlachou Marilena , Siamidi Angeliki , Anagnostopoulou Dionysia , Protopapa Chrystalla , Kompogennitaki Rodoula , Sakellaropoulou Aikaterini , Efstathiou Natasa , Papanastasiou Ioannis , Billia Maria , Mavromoustakos Thomas 
Published: June 2023

Introduction:
We report herein on the design and development of matrix tablets containing potent
synthetic melatonin (MLT) receptor analogues, the x-fluoro-y-methoxy substitiuted phenylalkylamides (compounds
I-IV), the preparation and melatoninergic potency of which was recently communicated.

Methods:
The presence of the fluorine atom in compounds I-IV, besides not affecting their binding affinity,
compared to the pineal hormone melatonin, it also slows down their metabolism, which is a major drawback of
MLT. However, as fluorine increases the lipophilicity, solid pharmaceutical formulations of I-IV, involving the
appropriate biopolymers for their modified release in aqueous media, were developed in the context of the present
work.

Results:
The release profile of analogues I-IV was found to be similar to that of MLT and also of the commercially
available drug, Circadin®. Some of these systems are suitable for dealing with sleep onset problems,
whilst others for dealing with combined sleep onset/sleep maintenance problems.

Conclusion:
Apart from the nature and relevant content of the formulants used, this bimodal release profile of
the new analogues depends, to a large extent, on the diverse structural arrangement of their side chains in space,
as nicely demonstrated by the molecular dynamics calculations, conducted in the context of this study.
Volatile Oil Containing Plants as Phytopharmaceuticals to Treat Psoriasis:
A Review
Authors: Vyas Priyanka J. , Wagh Shivani S. , Kalaskar Mohan G. , Patil Kalpesh R. , Sharma Ajay K. , Kazmi Imran , Al-Abbasi Fahad A. , Alzarea Sami I. , Afzal Obaid , Altamimi Abdulmalik S.A. , Gupta Gaurav , Patil Chandragouda R. 
Published: June 2023

Introduction:
Psoriasis is a chronic skin condition caused by an autoimmune response
that accelerates the life cycle of skin cells, resulting in the characteristic symptoms of scaling,
inflammation, and itching.

Methods:
Palliative treatment options for psoriasis often prioritize the use of volatile oils. These
oils contain monoterpenes, sesquiterpenes, and phenylpropanoids that are intricately linked to the
molecular cascades involved in the pathogenesis and symptoms of psoriasis. To evaluate the antipsoriatic
efficacy of volatile oils and their components, we conducted a systematic review of
scientific studies. Our literature search encompassed various online databases, including PubMed,
BIREME, SCIELO, Open Grey, Scopus, and ScienceDirect. The selected studies included experimental
in vitro/in vivo assessments as well as clinical studies that examined the potential of volatile
oils and their extracts as antipsoriatic agents. We excluded conference proceedings, case reports,
editorials, and abstracts. Ultimately, we identified and evaluated a total of 12 studies for
inclusion in our analysis.

Results:
The data collected, compiled, and analyzed strongly support the interaction between volatile
oils and their constituents with the key molecular pathways involved in the pathogenesis of
psoriasis and the development of its symptoms. Volatile oils play a significant role in the palliative
treatment of psoriasis, while their chemical constituents have the potential to reduce the symptoms
and recurrence of this condition.

Conclusion:
The current review highlights that the constituents found in volatile oils offer distinct
chemical frameworks that can be regarded as promising starting points for the exploration and
development of innovative antipsoriatic agents.
The Golden Spice for Life: Turmeric with the Pharmacological Benefits of Curcuminoids Components, Including Curcumin, Bisdemethoxycurcumin, and Demethoxycurcumins
Authors: Shahrajabian Mohamad Hesam , Sun Wenli 
Published: June 2023

Background:
Turmeric (Curcuma longa L.), belonging to the Zingiberaceae family, is a
perennial rhizomatous plant of tropical and subtropical regions. The three major chemical components
responsible for the biological activities of turmeric are curcumin, demethoxycurcumin, and bisdemethoxycurcumin.

Method:
The literature search included review articles, analytical studies, randomized control experiments,
and observations, which have been gathered from various sources, such as Scopus, Google
Scholar, PubMed, and ScienceDirect. A review of the literature was carried out using the keywords:
turmeric, traditional Chinese medicine, traditional Iranian medicine, traditional Indian medicine, curcumin,
curcuminoids, pharmaceutical benefits, turmerone, demethoxycurcumin, and bisdemethoxycurcumin.
The main components of the rhizome of the leaf are α-turmerone, β-turmerone, and arturmerone.

Result:
The notable health benefits of turmeric are antioxidant activity, gastrointestinal effects, anticancer
effects, cardiovascular and antidiabetic effects, antimicrobial activity, photoprotector activity,
hepatoprotective and renoprotective effects, and appropriate for the treatment of Alzheimer's disease
and inflammatory and edematic disorders

Discussion:
Curcuminoids are phenolic compounds usually used as pigment spices with many health
benefits, such as antiviral, antitumour, anti-HIV, anti-inflammatory, antiparasitic, anticancer, and antifungal
effects. Curcumin, bisdemethoxycurcumin, and demethoxycurcumin are the major active and
stable bioactive constituents of curcuminoids. Curcumin, which is a hydroponic polyphenol, and the
main coloring agent in the rhizomes of turmeric, has anti-inflammatory, antioxidant, anti-cancer, and
anticarcinogenic activities, as well as beneficial effects for infectious diseases and Alzheimer's disease.
Bisdemethoxycurcumin possesses antioxidant, anti-cancer, and anti-metastasis activities. Demethoxycurcumin,
which is another major component, has anti-inflammatory, antiproliferative, and
anti-cancer activities and is the appropriate candidate for the treatment of Alzheimer's disease.

Conclusion:
The goal of this review is to highlight the health benefits of turmeric in both traditional
and modern pharmaceutical sciences by considering the important roles of curcuminoids and other
major chemical constituents of turmeric.
Experiences of a Novel Structured Foot Examination Form for Patients With Diabetes From the Perspective of Health Care Professionals: Qualitative Study
Authors: Andersson Susanne , Scandurra Isabella , Nyström Ulrika , Varemo Marika , Hellstrand Tang Ulla 
Published: June 2023

Background
Diabetes is a growing threat to public health, and secondary diseases like foot complications are common. Foot ulcers affect the individual’s quality of life and are a great cost to society. Regular foot examinations prevent foot ulcers and are a recommended approach both in Sweden and worldwide. Despite existing guidelines, there are differences in the execution of the foot examination, which results in care inequality. A structured foot examination form based on current guidelines was developed in this study as the first step toward digitalized support in the daily routine, and was validated by diabetes health care professionals.

Objective
The study aimed to validate a structured foot examination form by assessing health care professionals’ experiences of working with it “foot side” when examining patients with diabetes.

Methods
Semistructured interviews were held in a focus group and individually with 8 informants from different diabetes professions, who were interviewed regarding their experiences of working with the form in clinical practice. The users’ data were analyzed inductively using qualitative content analysis. The study is part of a larger project entitled “Optimised care of persons with diabetes and foot complications,” with Västra Götaland Region as the responsible health care authority, where the results will be further developed.

Results
Experiences of working with the form were that it simplified the foot examination by giving it an overview and a clear structure. Using the form made differences in work routines between individuals apparent. It was believed that implementing the form routinely would contribute to a more uniform execution. When patients had foot ulcers, the risk categories (established in guidelines) were perceived as contradictory. For example, there was uncertainty about the definition of chronic ulcers and callosities. The expectations were that the future digital format would simplify documentation and elucidate the foot examination, as well as contribute to the accessibility of updated and relevant data for all individuals concerned.

Conclusions
The foot examination form works well as a support tool during preventive foot examination, creates a basis for decision-making, and could contribute to a uniform and safer foot examination with more care equality in agreement with current guidelines.

Trial Registration
ClinicalTrials.gov NCT05692778; https://clinicaltrials.gov/ct2/show/NCT05692778