bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of national context in the relationship between founder CEO and IPO performance
Authors: Tupper Christina , Mehta Anju 
Published: June 2023

Purpose
Although founders are often replaced with external CEOs prior to firms making IPOs, firms that do retain founder CEOs generally perform better at IPO. However, this relationship may be contingent upon context. This study aims to investigate how national context influences the relationship between a founder CEO and IPO long-run performance. The authors hypothesize that founder-CEOs will perform better in IPO firms in countries where managerial discretion, future orientation, and the level of conformity to professionalize management are high, and uncertainty avoidance is low.

Design/methodology/approach
Using insights from the upper echelon and institutional theory, the authors used hierarchical linear modeling to analyze over 1,000 firms across eight countries.

Findings
Founder CEOs perform best in IPO firms in a national context where managerial discretion is low, uncertainty avoidance is high and the level of conformity is high.

Originality/value
This study contributes to a growing area of cross-national IPO research in management by investigating the relationship between culture, management and IPO performance.
Digital skills and entrepreneurial intentions for final-year undergraduates: entrepreneurship education as a moderator and entrepreneurial alertness as a mediator
Authors: Abaddi Samer 
Published: June 2023

PurposeThis study aims to test the impact of digital skills on the entrepreneurial intentions of last-year undergraduate students in Jordanian universities, especially after the Coronavirus disease pandemic and the digital transformation in education and business patterns. In addition, it aims to assess the role of entrepreneurial alertness as a mediator and entrepreneurship education as a moderator in the relationship between the independent and dependent variables.Design/methodology/approachThe quantitative study used a questionnaire distributed to 401 students from different Jordanian universities. The data was collected over 2 months and two structural equation models were developed using AMOS 25 to examine the relationship.FindingsA significant negative relationship was found between digital skills and entrepreneurial intentions of last-year undergraduate students in Jordanian universities post-coronavirus disease 2019 (COVID-19) pandemic. A fully mediating role of the alertness variable has appeared in addition to a significant moderating role of entrepreneurship education.Originality/valueThis is the first study that attempts to investigate the impact of digital skills on students' entrepreneurial intentions in Jordan after the COVID-19 pandemic, In addition, it is one of the few studies that assess the mediator's and moderator's effects on the same conditions. Finally, the study provided a review of the definitions and models used as part of the contribution to upcoming reviews.
Involvement of the genus Corynebacterium in the pathogenesis of pigmented intratarsal keratinous cyst
Authors: Yoshikawa Miyuki , Rokunohe Daiki , Takahashi Mika , Korekawa Ayumi , Nakajima Koji , Nakano Hajime , Akemoto Yui , Kurose Akira , Sawamura Daisuke 
Published: June 2023

AbstractIntratarsal keratinous cyst (IKC) is a benign cystic lesion of the eyelid that retains keratin flakes. IKCs are usually yellow to white cystic lesions but rarely become brown or gray‐blue, making clinical diagnosis difficult. The mechanisms by which dark brown pigments are generated in pigmented IKC are unclear. The authors report a case of pigmented IKC that had melanin pigments within the lining of the cyst wall and within the cyst. Focal infiltrates of lymphocytes were observed in the dermis, particularly beneath the cyst wall in areas with more melanocytes and intense melanin deposition. These pigmented parts faced bacterial colonies inside the cyst, which were identified to be Corynebacterium species in a bacterial flora analysis. The pathogenesis of pigmented IKC in relation to inflammation and bacterial flora is discussed.
Boldness predicts plasticity in flight responses to winds
Authors: Gillies Natasha , Weimerskirch Henri , Thorley Jack , Clay Thomas A. , Martín López Lucía Martina , Joo Rocío , Basille Mathieu , Patrick Samantha C. 
Published: June 2023

Abstract

Behavioural plasticity can allow populations to adjust to environmental change when genetic evolution is too slow to keep pace. However, its constraints are not well understood. Personality is known to shape individual behaviour, but its relationship to behavioural plasticity is unclear.

We studied the relationship between boldness and behavioural plasticity in response to wind conditions in wandering albatrosses (Diomedea exulans).

We fitted multivariate hidden Markov models to an 11‐year GPS dataset collected from 294 birds to examine whether the probability of transitioning between behavioural states (rest, prey search and travel) varied in response to wind, boldness and their interaction.

We found that movement decisions varied with boldness, with bolder birds showing preferences for travel, and shyer birds showing preferences for search. For females, these effects depended on wind speed. In strong winds, which are optimal for movement, females increased time spent in travel, while in weaker winds, shyer individuals showed a slight preference for search, while bolder individuals maintained preference for travel.

Our findings suggest that individual variation in behavioural plasticity may limit the capacity of bolder females to adjust to variable conditions and highlight the important role of behavioural plasticity in population responses to climate change.
Pervasive impacts of climate change on the woodiness and ecological generalism of dry forest plant assemblages
Authors: Moura Mario R. , do Nascimento Fellipe A. O. , Paolucci Lucas N. , Silva Daniel P. , Santos Bráulio A. 
Published: June 2023

Abstract

Climate emergency is a significant threat to biodiversity in the 21st century, but species will not be equally affected. In summing up the responses of different species at the local scale, we can assess changes in the species quantity and composition of biotic assemblages.

We used more than 420K curated occurrence records of 3060 plant species to model current and future patterns of plant species distribution in one of the world's largest tropical dry forests—the Caatinga. While allowing different model extrapolation scenarios, we estimated potential changes in the species richness and composition of dryland plant assemblages in response to projected climate change, and assessed how the ecological generalism and woodiness of plant assemblages can be impacted by the climate crisis.

More than 99% of plant assemblages were projected to lose species by 2060, with biotic homogenisation—the decrease in spatial beta diversity—forecasted in 40% of the Caatinga. The replacement of narrow‐range woody species by wide‐range non‐woody ones should impact at least 90% of Caatinga plant assemblages. The exacerbated species loss in the dryland plant assemblages was connected to the heterogenisation and homogenisation of biotic assemblages. Still, the magnitude of climate change impacts on ecological generalism and woodiness patterns of dryland plant assemblages differ according to the direction of the biotic change process.

Synthesis. The future increase in aridity will change the patterns of woodiness and ecological generalism of tropical dry forest plant assemblages by decreasing vegetation diversity and complexity. The projected biotic changes in dryland plant assemblages indicate the erosion of ecosystem services linked to biomass productivity and carbon storage. We highlight the importance of long‐term conservation planning for maintaining tropical dry forests.
Women as Frontier‐Makers in the Llibre dels fets of James I of Aragon
Authors: Snowden Emma 
Published: June 2023

AbstractMuch of the reign of James I of Aragon (1213–76) was devoted to the conquest and colonisation of Islamic Majorca and Valencia, as he elaborates in his Llibre dels fets, or Book of Deeds. This article offers a close reading of the role of women and feminine figures in the Llibre, arguing that James portrays them as frontier‐makers who signal and embody the Christianisation of previously Islamic territory. It also explores what the relationship between women and the frontier can tell us about the gendered construction of power in thirteenth‐century Aragon.
Restin protein expression in non‐small cell lung cancer
Authors: Nana Frank Aboubakar , Lamberts Virginie , Hoton Delphine , Stanciu Claudia Pop , Lecocq Marylène , Carlier François M. , Duplaquet Fabrice , Pirard Lionel , Pilette Charles , Bihin Benoît , Ocak Sebahat 
Published: June 2023

AbstractBackgroundRestin is a member of the melanoma‐associated antigen (MAGE) superfamily. Its expression has been reported to be up‐ or downregulated in cancer. Preclinical data suggest it is a tumor suppressor. In this study, we aimed to evaluate restin expression and prognostic value in non‐small cell lung cancer (NSCLC).MethodsRestin expression was analyzed by immunohistochemistry in three tissue microarrays consisting of formalin‐fixed/paraffin‐embedded NSCLC specimens from 113 patients, represented in triplicate. Restin staining H‐score was the result of the staining intensity (0‐no, 1‐weak, 2‐moderate, and 3‐strong) multiplied by the percentage of stained tumor cells; it was defined as low if 1–100, moderate if 101–200, and strong if 201–300. Haverage‐score was the average H‐score in the triplicate. Restin Haverage‐scores were tested for correlations with clinical and pathological characteristics and patient outcome.ResultsRestin expression was localized to the cytoplasm, with nuclear enhancement, of 112/113 (99.1%) NSCLCs. Restin Haverage‐scores were 0 in 1/113 (0.88%), low in 15/113 (13.3%), moderate in 48/113 (42.5%), and strong in 49/113 (43.4%) NSCLCs. Restin Haverage‐scores did not correlate with NSCLC histological subtype, disease stage, recurrence/progression‐free, or overall survival.ConclusionRestin is moderately to strongly expressed in the majority of NSCLC tumors but its expression has no prognostic value in patients with NSCLC.
The experiences of people with disability and their families/carers navigating the NDIS planning process in regional, rural and remote regions of Australia: Scoping review
Authors: Veli‐Gold Sarah , Gilroy John , Wright Wayne , Bulkeley Kim , Jensen Heather , Dew Angela , Lincoln Michelle 
Published: June 2023

AbstractBackgroundAustralia's National Disability Insurance Scheme (NDIS) was launched in 2013 to provide financial support packages for people with disability to purchase supports and services to enhance independence. People with disability are required to develop a plan with the National Disability Insurance Agency (NDIA), the government department responsible for managing the NDIS. This scoping review aims to ascertain the level of research into people's experience of the NDIS planning process in these geographic areas.MethodologyResearch publication databases were searched using a specific search string to identify research about people with disability and their families/carer's experiences of the NDIS planning process in regional, rural and remote regions of Australia. The Mixed Methods Appraisal Tool (MMAT) was adopted to appraise the quality of the research publications. Research publications focused on Aboriginal and Torres Strait Islander people were additionally appraised using the Aboriginal and Torres Strait Islander Quality Appraisal Tool developed by the Centre for Excellence in Aboriginal Chronic Disease Knowledge Translation and Exchange. A thematic synthesis of the publications' contents was undertaken to ascertain people with disabilities and carers experience of the NDIS planning process.ResultsTen (N = 10) research papers were found that met the inclusion criteria. Two papers were policy reviews and reported on the improvements of the NDIS planning process since its conception. The analysis found the research archive focused on five themes: (1) healthcare workforce and NDIA staff; (2) NDIS package holders and carers lack of awareness of the NDIS; (3) cultural/socio‐economic barriers; (4) travel funding; and (5) emotional burden of the NDIS planning process.ConclusionThere are limited papers available that explore people's experiences of the NDIS planning process in regional, rural and remote regions of Australia. This systematic review illuminates the difficulties, barriers and concerns of people with disability and their carers about the planning process.
Short‐course subcutaneous treatment with PQ Grass strongly improves symptom and medication scores in grass allergy
Authors: de Kam P. J. , Zielen S. , Bernstein J. A. , Berger U. , Berger M. , Cuevas M. , Cypcar D. , Fuhr‐Horst A. , Greisner W. A. , Jandl M. , Laßmann S. , Worm M. , Matz J. , Sher E. , Smith C. , Steven G. C. , Mösges R. , Shamji M. H. , DuBuske L. , Borghese F. , Oluwayi K. , Zwingers T. , Seybold M. , Armfield O. , Heath M. D. , Hewings S. J. , Kramer M. F. , Skinner M. A. 
Published: June 2023

AbstractBackgroundA modified grass allergen subcutaneous immunotherapy (SCIT) product with MicroCrystalline Tyrosine and monophosphoryl lipid‐A as an adjuvant system (Grass MATA MPL [PQ Grass]) is being developed as short‐course treatment of grass‐pollen allergic rhinitis (SAR) and/or rhinoconjunctivitis. We sought to evaluate the combined symptom and medication score (CSMS) of the optimized cumulative dose of 27,600 standardized units (SU) PQ Grass in a field setting prior to embarking on a pivotal Phase III trial.MethodsIn this exploratory, randomized, double‐blind, placebo‐controlled trial subjects were enrolled across 14 sites (Germany and the United States of America). Six pre‐seasonal subcutaneous injections of PQ Grass (using conventional or extended regimens) or placebo were administered to 119 subjects (aged 18–65 years) with moderate‐to‐severe SAR with or without asthma that was well‐controlled. The primary efficacy endpoint was CSMS during peak grass pollen season (GPS). Secondary endpoints included Rhinoconjunctivitis Quality of Life Questionnaire standardized (RQLQ‐S) and allergen‐specific IgG4 response.ResultsThe mean CSMS compared to placebo was 33.1% (p = .0325) and 39.5% (p = .0112) for the conventional and extended regimens, respectively. An increase in IgG4 was shown for both regimens (p < .01) as well as an improvement in total RQLQ‐S for the extended regimen (mean change −0.72, p = .02). Both regimens were well‐tolerated.ConclusionsThis trial demonstrated a clinically relevant and statistically significant efficacy response to PQ Grass. Unprecedented effect sizes were reached for grass allergy of up to ≈40% compared to placebo for CSMS after only six PQ Grass injections. Both PQ Grass regimens were considered equally safe and well‐tolerated. Based on enhanced efficacy profile extended regime will be progressed to the pivotal Phase III trial.
The adipose‐derived stem cell peptide ADSCP2 alleviates hypertrophic scar fibrosis via binding with pyruvate carboxylase and remodeling the metabolic landscape
Authors: Li Jingyun , Yin Yiliang , Zou Jijun , Zhang Enyuan , Li Qian , Chen Ling , Li Jun 
Published: June 2023

AbstractAimThe purpose of this study was to investigate the function and mechanism of a novel peptide derived from adipose‐derived stem cell‐conditioned medium (ADSC‐CM).MethodsMass spectrometry was applied to identify expressed peptides in ADSC‐CM obtained at different time points. The cell counting kit‐8 assay and quantitative reverse transcription polymerase chain reactions were performed to screen the functional peptides contained within ADSC‐CM. RNA‐seq, western blot, a back skin excisional model of BALB/c mice, the peptide pull‐down assay, rescue experiments, untargeted metabolomics, and mixOmics analysis were performed to thoroughly understand the functional mechanism of selected peptide.ResultsA total of 93, 827, 1108, and 631 peptides were identified in ADSC‐CM at 0, 24, 48, and 72 h of conditioning, respectively. A peptide named ADSCP2 (DENREKVNDQAKL) derived from ADSC‐CM inhibited collagen and ACTA2 mRNAs in hypertrophic scar fibroblasts. Moreover, ADSCP2 facilitated wound healing and attenuated collagen deposition in a mouse model. ADSCP2 bound with the pyruvate carboxylase (PC) protein and inhibited PC protein expression. Overexpressing PC rescued the reduction in collagen and ACTA2 mRNAs caused by ADSCP2. Untargeted metabolomics identified 258 and 447 differential metabolites in the negative and positive mode, respectively, in the ADSCP2‐treated group. The mixOmics analysis, which integrated RNA‐seq and untargeted metabolomics data, provided a more holistic view of the functions of ADSCP2.ConclusionOverall, a novel peptide derived from ADSC‐CM, named ADSCP2, attenuated hypertrophic scar fibrosis in vitro and in vivo, and the novel peptide ADSCP2 might be a promising drug candidate for clinical scar therapy.
Testing indirect effect with a complete or incomplete dichotomous mediator
Authors: Jia Fan , Wu Wei , Chen Po‐Yi 
Published: June 2023

AbstractPast methodological research on mediation analysis mainly focused on situations where all variables were complete and continuous. When issues of categorical data occur combined with missing data, more methodological considerations are involved. Specifically, appropriate decisions need to be made on estimation methods of the indirect effects and on confidence intervals for testing the indirect effects with accommodations of missing data. We compare strategies that address these issues based on a model with a dichotomous mediator, aiming to provide guidelines for researchers facing such challenges in practice.
Data Stories of Water: Studying the Communicative Role of Data Visualizations within Long‐form Journalism
Authors: Garreton M. , Morini F. , Paz Moyano D. , Grün G.‐C. , Parra D. , Dörk M. 
Published: June 2023

AbstractWe present a methodology for making sense of the communicative role of data visualizations in journalistic storytelling and share findings from surveying water‐related data stories. Data stories are a genre of long‐form journalism that integrate text, data visualization, and other visual expressions (e.g., photographs, illustrations, videos) for the purpose of data‐driven storytelling. In the last decade, a considerable number of data stories about a wide range of topics have been published worldwide. Authors use a variety of techniques to make complex phenomena comprehensible and use visualizations as communicative devices that shape the understanding of a given topic. Despite the popularity of data stories, we, as scholars, still lack a methodological framework for assessing the communicative role of visualizations in data stories. To this extent, we draw from data journalism, visual culture, and multimodality studies to propose an interpretative framework in six stages. The process begins with the analysis of content blocks and framing elements and ends with the identification of dimensions, patterns, and relationships between textual and visual elements. The framework is put to the test by analyzing 17 data stories about water‐related issues. Our observations from the survey illustrate how data visualizations can shape the framing of complex topics.
A Comparative Evaluation of Visual Summarization Techniques for Event Sequences
Authors: Zinat Kazi Tasnim , Yang Jinhua , Gandhi Arjun , Mitra Nistha , Liu Zhicheng 
Published: June 2023

AbstractReal‐world event sequences are often complex and heterogeneous, making it difficult to create meaningful visualizations using simple data aggregation and visual encoding techniques. Consequently, visualization researchers have developed numerous visual summarization techniques to generate concise overviews of sequential data. These techniques vary widely in terms of summary structures and contents, and currently there is a knowledge gap in understanding the effectiveness of these techniques. In this work, we present the design and results of an insight‐based crowdsourcing experiment evaluating three existing visual summarization techniques: CoreFlow, SentenTree, and Sequence Synopsis. We compare the visual summaries generated by these techniques across three tasks, on six datasets, at six levels of granularity. We analyze the effects of these variables on summary quality as rated by participants and completion time of the experiment tasks. Our analysis shows that Sequence Synopsis produces the highest‐quality visual summaries for all three tasks, but understanding Sequence Synopsis results also takes the longest time. We also find that the participants evaluate visual summary quality based on two aspects: content and interpretability. We discuss the implications of our findings on developing and evaluating new visual summarization techniques.
Tac‐Anticipator: Visual Analytics of Anticipation Behaviors in Table Tennis Matches
Authors: Wang Jiachen , Wu Yihong , Zhang Xiaolong , Zeng Yixin , Zhou Zheng , Zhang Hui , Xie Xiao , Wu Yingcai 
Published: June 2023

AbstractAnticipation skill is important for elite racquet sports players. Successful anticipation allows them to predict the actions of the opponent better and take early actions in matches. Existing studies of anticipation behaviors, largely based on the analysis of in‐lab behaviors, failed to capture the characteristics of in‐situ anticipation behaviors in real matches. This research proposes a data‐driven approach for research on anticipation behaviors to gain more accurate and reliable insight into anticipation skills. Collaborating with domain experts in table tennis, we develop a complete solution that includes data collection, the development of a model to evaluate anticipation behaviors, and the design of a visual analytics system called Tac‐Anticipator. Our case study reveals the strengths and weaknesses of top table tennis players' anticipation behaviors. In a word, our work enriches the research methods and guidelines for visual analytics of anticipation behaviors.
Evaluating View Management for Situated Visualization in Web‐based Handheld AR
Authors: Batch A. , Shin S. , Liu J. , Butcher P. W. S. , Ritsos P. D. , Elmqvist N. 
Published: June 2023

AbstractAs visualization makes the leap to mobile and situated settings, where data is increasingly integrated with the physical world using mixed reality, there is a corresponding need for effectively managing the immersed user's view of situated visualizations. In this paper we present an analysis of view management techniques for situated 3D visualizations in handheld augmented reality: a shadowbox, a world‐in‐miniature metaphor, and an interactive tour. We validate these view management solutions through a concrete implementation of all techniques within a situated visualization framework built using a web‐based augmented reality visualization toolkit, and present results from a user study in augmented reality accessed using handheld mobile devices.