bluuebunny/crossref_metadata_2025_split huggingface dataset:
Projecting the Potential Budget Impact Analysis of Paliperidone Palmitate in Egyptian Adult Patients with Schizophrenia
Authors: Elsisi Gihan , Ezzat Mohamed , Ramadan Mohamed 
Published: August 2023

Background: Schizophrenia is a serious mental disorder that has greater negative consequences on role functioning than many other severe chronic diseases. Objective: We evaluated the economic impact of long-acting injections of paliperidone palmitate (PP) vs daily oral antipsychotics to treat chronic schizophrenia from a societal perspective over a 2-year period. Methods: A static budget impact model was developed to compare PP with daily oral antipsychotics (risperidone, olanzapine, and aripiprazole) in the treatment of patients with chronic schizophrenia. Our study included treatments used during relapse and hospitalization, validated by an expert panel. The clinical parameters were extracted from the PRIDE trial. Direct medical costs and indirect costs were measured. The unit cost of drug acquisition for all medications was extracted from the public sector. One-way sensitivity analyses were conducted. Results: The target population in our model was estimated to be 142 incident patients. In the first year, the total drug costs in Egyptian pounds (EGP) for PP and oral antipsychotics were £2.7 million and £724 004, respectively, while the total medical costs for PP and oral antipsychotics were £3 million and £5.6 million, respectively. In the second year, the total drug costs for PP and oral antipsychotics were £2.7 million and £724 004, respectively, while the total medical costs for PP and oral antipsychotics were £3 million and £5 million, respectively. The total costs for PP (£11.6 million) over 2 years were less than those of oral antipsychotics without PP (£12.7 million). PP produced an estimated budget savings of £1 046 561 (budget savings per patient per year, £3667). In addition, PP resulted in the avoidance of 18 hospitalizations per year compared with the without-PP arm. Sensitivity analyses showed that the percent of hospitalizations for both oral antipsychotics and PP had the greatest impact on the results. Conclusion: The lower hospitalization rates associated with PP offset the increase in drug costs. PP may potentially be cost-saving compared with the standard of care in chronic schizophrenia in Egyptian representative healthcare settings. Policy makers may consider this approach to improve patient outcomes and budget sustainability.
Experiencias y valoración del profesorado respecto del liderazgo de docentes directivos
Authors: Jara Pacheco Jazmín , Pérez Cruz Pablo , Altamirano Soto Marcela 
Published: August 2023

El ejercicio del liderazgo en la gestión escolar es un desafío que tienen todas las escuelas en Chile y en el mundo, más aún en aquellos sistemas educativos en donde el imperativo es transitar a ciclos de mejora que apunten hacia una mayor equidad, inclusión y justicia social. Este desafío involucra no sólo potenciar habilidades y aprendizajes de los estudiantes sino también renovar y despertar motivaciones en el cuerpo docente, generando sentido de pertenencia, compromiso y responsabilidad frente al quehacer educativo. En esta investigación se indaga la experiencia y la valoración del profesorado sobre los distintos tipos de liderazgo que ejercen los docentes directivos, a través de un enfoque cualitativo y diseño fenomenológico, utilizando para ello la técnica de la entrevista en profundidad, se entrevistó a 20 profesores de diversas instituciones educativas. Entre los resultados se destaca la valoración de liderazgos de tipo instruccional y distribuido, aparece de manera incipiente el enfoque de justicia social, por sobre otros, y como el impacto que tienen los docentes directivos en la organización escolar determina cómo será el desempeño docente y la eficacia-eficiencia de la institución educativa.
Statistical Relationship between Long-duration High-energy Gamma-Ray Emission and Solar Energetic Particles
Authors: Bruno A. , de Nolfo G. A. , Ryan J. M. , Richardson I. G. , Dalla S. 
Published: August 2023

Abstract
Large solar eruptions are often associated with long-duration γ-ray emission extending well above 100 MeV. While this phenomenon is known to be caused by high-energy ions interacting with the solar atmosphere, the underlying dominant acceleration process remains under debate. Potential mechanisms include continuous acceleration of particles trapped within large coronal loops or acceleration at coronal mass ejection (CME)-driven shocks, with subsequent back-propagation toward the Sun. As a test of the latter scenario, previous studies have explored the relationship between the inferred particle population producing the high-energy γ-rays and the population of solar energetic particles (SEPs) measured in situ. However, given the significant limitations on available observations, these estimates unavoidably rely on a number of assumptions. In an effort to better constrain theories of the γ-ray emission origin, we reexamine the calculation uncertainties and how they influence the comparison of these two proton populations. We show that, even accounting for conservative assumptions related to the γ-ray flare, SEP event, and interplanetary scattering modeling, their statistical relationship is only poorly/moderately significant. However, though the level of correlation is of interest, it does not provide conclusive evidence for or against a causal connection. The main result of this investigation is that the fraction of the shock-accelerated protons required to account for the γ-ray observations is >20%–40% for six of the 14 eruptions analyzed. Such high values argue against current CME-shock origin models, predicting a <2% back-precipitation; hence, the computed number of high-energy SEPs appears to be greatly insufficient to sustain the measured γ-ray emission.
Detection of the Low-stellar-mass Host Galaxy of a z ∼ 6.25 Quasar with JWST
Authors: Stone Meredith A. , Lyu 吕 Jianwei 建伟 , Rieke George H. , Alberts Stacey 
Published: August 2023

Abstract
We characterize the stellar mass of J2239+0207, a z ∼ 6.25 sub-Eddington quasar (M
1450 = −24.6), using dedicated JWST/NIRCam medium-band observations of a nearby point-spread function star to remove the central point source and reveal the underlying galaxy emission. We detect the host galaxy in two bands longward of the Balmer break, obtaining a stellar mass of ∼1010
M
⊙, more than an order of magnitude less than this quasar’s existing measured [C ii] dynamical mass. We additionally calculate the mass of J2239+0207's central supermassive black hole using JWST/NIRSpec integral field unit observations, and determine that the black hole is ∼15 times more massive than predicted by the local M
BH–M
* relation, similar to many high-redshift quasars with dynamical masses determined via millimeter-wave line widths. We carefully consider potential selection effects at play, and find that even when z ∼ 6 quasars are compared to a local sample with similarly determined dynamical masses, many of the high-redshift quasars appear to possess overmassive black holes. We conclude z ∼ 6 quasars are likely to have a larger spread about the M
BH–M
* relation than observed in the local Universe.
Hidden Companions to Intermediate-mass Stars. IX. Discovery of a 1.5 M
⊙, 1 au Companion to the Primary within the Multiple HIP 57606*
Authors: Waisberg Idel , Klein Ygal , Katz Boaz 
Published: August 2023

Abstract
HIP 57606 is an intermediate-mass a ∼ 88 au visual binary (A+B) that also has 680 au (C) and a 120,000 au (D) companions. Here we report on a VLTI/GRAVITY interferometric observation that revealed that the primary star A is itself a close binary with a 83% K band flux ratio companion at a projected separation ρ = 14.8 mas ↔ 1.0 au. Through isochrone fitting we find masses M
Aa = 1.58M
⊙, M
Ab = 1.49M
⊙ and M
B = 1.15M
⊙ and an age 1 Gyr for the inner triple. The latter will evolve to become a double or triple white dwarf system within about 6 Gyr and which will be under the dynamical influence of the outer companion C.
Inventory of tiger- and ground-beetles (Coleoptera, Caraboidea, Cicindelidae and Carabidae) in two sampling seasons of the Gorongosa National Park, Mozambique
Authors: Serrano Artur , Baptista Martim , Carvalho Rui , Boieiro Mário , Mendes Sara , Bartz Marie , Timóteo Sérgio , Azevedo-Pereira Henrique , Aguiar Carlos , Alves da Silva António , Alves Joana , Briones Maria , Borges Paulo , Sousa José , Martins da Silva Pedro 
Published: August 2023

The Gorongosa National Park (Mozambique) is one of the most emblematic protected areas in Africa, well known for its vertebrate biodiversity and restoration ecology efforts following the Mozambican civil war in 1992. The invertebrate biodiversity of Gorongosa National Park is still poorly studied, although the scarce information available indicates the existence of a rich number of species, namely in the case of tiger- and ground-beetles (Coleoptera, Caraboidea). Moreover, the study of arthropod assemblages is key for designing conservation practices since they are potentially accurate biodiversity and ecological indicators. Hence, the diversity assessment of Caraboidea beetles using standardised methodologies is likely to provide a new insight for future conservation planning and help to quantify the effects of climate change in areas identified as vulnerable to anthropogenic pressures, such as the Gorongosa National Park.We report the occurrence of five tiger beetles (Cicindelidae) and 93 ground-beetles (Carabidae) species/morphospecies in Gorongosa National Park from a field survey funded by the ECOASSESS project. Sampling was performed in the four main habitat types present in the Park (miombo tropical forest, mixed dry forest, transitional forest and grasslands) between 25 October and 25 November 2019. In this sampling window, the turnover of Caraboidea species from the dry season to the wet season was recorded for the first time. Twenty-eight species of ground-beetles are new records to Mozambique, including three new subgenera and three new genera. Additional information on species phenology and habitat preferences is also provided.
A new species of Paracedicus Fet, 1993 (Araneae, Desidae) from Turkey
Authors: Gündüz Gökhan 
Published: August 2023

The desid spider genus Paracedicus Fet, 1993 comprises seven species distributed in the western Palaearctic. From Turkey, only Paracedicus baram Levy, 2007 has been recorded so far.
A new species, Paracedicus turcicus sp. nov., is described, based on specimens of both sexes collected in Eastern Anatolia. Detailed morphological description and photographs are provided. Additionally, a key to all species of the genus and a distribution map are provided.
Urinary Symptoms Among People With Neurogenic Lower Urinary Tract Dysfunction (NLUTD) Vary by Bladder Management
Authors: Tractenberg Rochelle E. , Groah Suzanne L. , Frost Jamie K. , Yumoto Futoshi , Rounds Amanda K. , Ljungberg Inger H. 
Published: August 2023

Objectives
To determine whether assessment and decision-making around urinary symptoms in people with neurogenic lower urinary tract dysfunction (NLUTD) should depend on bladder management.

Methods
Three surveys of urinary symptoms associated with NLUTD (USQNBs) were designed specific to bladder management method for those who manage their bladders with indwelling catheter (IDC), intermittent catheter (IC), or voiding (V). Each was deployed one time to a national sample. Subject matter experts qualitatively assessed the wording of validated items to identify potential duplicates. Clustering by unsupervised structural learning was used to analyze duplicates. Each item was classified into mutually exclusive and exhaustive categories: clinically actionable (“fever”), bladder-specific (“suprapubic pain”), urine quality (“cloudy urine”), or constitutional (“leg pain”).

Results
A core of 10 “NLUTD urinary symptoms” contains three clinically actionable, bladder-specific, and urine quality items plus one constitutional item. There are 9 (IDC), 11 (IC), and 8 (V) items unique to these instruments. One decision-making protocol applies to all instruments.

Conclusion
Ten urinary symptoms in NLUTD are independent of bladder management, whereas a similar number depend on bladder management. We conclude that assessment of urinary symptoms for persons with NLUTD should be specific to bladder management method, like the USQNBs are.
Intravesical Lactobacillus rhamnosus GG Alters Urobiome Composition and Diversity Among People With Neurogenic Lower Urinary Tract Dysfunction
Authors: Groah Suzanne L. , Rounds Amanda K. , Pérez-Losada Marcos 
Published: August 2023

Background
Neurogenic bladder is associated with bacterial colonization and frequent urinary tract infections.

Objectives
To explore the effects of one to two doses of intravesical Lactobacillus rhamnosus GG (LGG) on the urobiomes of adults with spinal cord injury/disease (SCI/D) who manage their bladders with intermittent catheterization (IC).

Methods
This was a pilot substudy within an 18-month phase 1 clinical trial of self-instilled intravesical LGG for urinary symptoms as directed by the Self-Management Protocol using Probiotics (SMP-Pro). Urine samples were collected monthly when participants were asymptomatic. When SMP-Pro “trigger” symptoms (cloudier and/or more foul-smelling urine) occurred, urine samples were collected immediately pre-LGG instillation and 24 to 48 hours after LGG instillation. Urine was collected via a new catheter, immediately placed on ice/freezer, and processed within 12 hours. Genomic DNA was isolated, and the V4 region of the 16S rRNA bacterial gene was amplified and high throughput sequenced. Amplicon sequence variants were inferred and bacterial composition, community structure, and variation across clinical phenotypes were determined.

Results
126 urine samples were collected from 26 participants (SCI/D = 23; multiple sclerosis = 2; spina bifida = 1) between 20 and 57 years of age. The urobiomes were characterized by four dominant phyla (&gt;1%): Bacteroidetes, Firmicutes, Proteobacteria, and Actinobacteria, which were comprised of six dominant genera (&gt;3%): Escherichia/Shigella (29.1%), Klebsiella (22.4%), Proteus (15.2%), Aerococcus (6.3%), Streptococcus (6.0%), and Pluralibacter (3.0%). Post-LGG samples were associated with a decline in Escherichia/Shigella predominance (p &lt; .001) and altered bacterial diversity (p &lt; .05).

Conclusion
Among people with SCI/D who use IC, intravesical LGG alters the bacterial composition and diversity of the urine ecosystem, potentially disrupting the uropathogenic urobiome.
Pengaruh Penggunaan LPM MATA Terhadap Pemenuhan Kebutuhan Informasi Mahasiswa Ilmu Komunikasi Universitas Tidar
Authors: Wulandari Dita , Al Maliki Fatahilah , Pamungkas Muhammad Romli 
Published: August 2023

Penelitian ini dilakukan untuk mengetahui bagaimana pengaruh penggunaan LPM MATA terhadap pemenuhan kebutuhan informasi mahasiswa Ilmu Komunikasi Universitas Tidar. LPM MATA merupakan sebuah unit kegiatan mahasiswa berbentuk lembaga yang menjadi wadah penampung dan penyebaran berita informasi terkait kampus maupun nasional. Penelitian ini bertujuan untuk menganalisis bagaimana pengaruh yang dihasilkan dari penggunaan media LPM MATA terhadap pemenuhan kebutuhan informasi mahasiswa program studi Ilmu Komunikasi. Metode penelitian yang digunakan adalah kuantitatif dengan metode survei. Pengambilan sampel menggunakan teknik nonprobablity sampling berjenis purposive sampling. Populasi dalam penelitian ini adalah mahasiswa aktif program studi Ilmu Komunikasi Universitas Tidar yang mengetahui informasi terkait LPM MATA dan mengikuti LPM MATA. Sedangkan sampel yang diambil menggunakan rumus slovin menjadi dasar keputusan dalam menentukan jumlah responden yang mengisi kuesioner secara online, yakni sebanyak 90 orang responden. Teknik analisis yang digunakan adalah analisis deskriptif, uji normalitas, uji korelasi, uji regresi linear sederhana, dan uji koefisien determinasi. Berdasarkan analisis menggunakan uji T didapati hasil tidak ada pengaruh antara penggunaan LPM MATA terhadap pemenuhan kebutuhan informasi mahasiswa Ilmu Komunikasi Untidar.
The Benefits of Gamification on User Experience: A Systematic Literature Review
Authors: Putri Mutia Fadhila , Razi A Muhammad 
Published: August 2023

influence the success of a product, and gamification is one purposed method which is expected to improve the user experience. But actually, whether gamification can provide benefits to increase user experience has not explicitly been explained before. This study purpose identifies the benefits implementation gamification for improving the user experience. To achieve the objectives, this study conducts the systematic literature review that summarized all the studies required in Gamification and User experience context. This study has discovered 539 papers and do three steps to select primary studies through kitchenham method with the results of the first stage is 314 research papers. Then, for the 2nd stage find 50 papers, and finally, the 3rd stage finds 16 best papers. During a systematic literature review, the study is a variety approach depends on two clustered such as intangible and tangible benefits. This study identified gamification have positive intangible and tangible benefits for improving the user experience.
The Role of Cryptocurrencies in Shaping the Future of Mobile Money Services in Lusaka, Zambia.
Authors: Nyika Andrew Mweemba 
Published: August 2023

Purpose: This research provides a comprehensive exploration of the intersection between cryptocurrencies and mobile money services, particularly in the Zambian context. The study illuminates both the potential and the challenges of integrating cryptocurrencies with mobile money services, providing a novel contribution to the existing body of knowledge.
Methodology: Utilizing descriptive and inferential statistics, the study reveals a moderately strong positive correlation between cryptocurrency usage and both the volume and frequency of mobile money transactions. However, it also identifies significant barriers to adoption, including a lack of user awareness, security concerns, regulatory ambiguity, and the volatility of cryptocurrencies.
Findings Through thematic, content, and comparative analysis, the study underscores the regulatory challenges, increased security risks, and the added burdens of compliance with anti-money laundering (AML) and know-your-customer (KYC) regulations associated with the integration of cryptocurrencies. Moreover, the research identifies the potential disruption of existing mobile money systems by blockchain technology and the significant infrastructural investments and regulatory adaptation that it necessitates.
Unique contribution to theory, policy and practice: The research proposes two strategies for aligning the regulatory frameworks for mobile money services and cryptocurrencies in Zambia: development of specific regulations or guidelines for cryptocurrencies that align with existing mobile money rules, and establishment of a separate regulatory framework that addresses the unique characteristics of cryptocurrencies. In highlighting the transformative potential of blockchain technology and the importance of user perspectives and regional variables in the integration process, the study offers valuable insights for researchers, policymakers, and practitioners. The research underscores the necessity for a responsive approach, continuous review, and update of regulatory frameworks, emphasizing consumer protection, market stability, and the promotion of innovation. While the research confirms the promising opportunities, cryptocurrencies offer to enhance mobile money services, it also emphasizes the need for careful consideration of potential adverse effects. Future research is encouraged to continue exploring this rapidly evolving field, broadening the geographical scope, and focusing on user education and robust security measures.
A Multicomponent Cognitive Intervention May Improve Self-Reported Daily Function of Adults With Subjective Cognitive Decline
Authors: Chang Ling-Hui , Tang Yuan Ling , Chiu Ming-Jang , Wu Chien-Te , Mao Hui-Fen 
Published: August 2023

Abstract
Importance: Limited evidence exists to support cognitive intervention improving the daily function of adults with subjective cognitive decline (SCD).
Objective: To examine the preliminary efficacy of a group-based multicomponent cognitive intervention that integrates Lifestyle Redesign® (LR) techniques.
Design: Single-arm two-period crossover trial; 16-wk waiting period, 16-wk intervention, and 16-wk follow-up.
Setting: Memory clinic in a medical center, Taiwan.
Participants: Purposive sample of adults ages &gt;55 yr with SCD.
Intervention: Sixteen 1.5-hr weekly multicomponent sessions of cognitive training, cognitive rehabilitation, psychological intervention, and lifestyle intervention.
Outcomes and Measures: Primary outcomes were (1) self-reported daily function, measured with the Activities of Daily Living Questionnaire (ADLQ) and Cognitive Failure Questionnaire; (2) performance-based daily function, measured with the Brief University of California San Diego Performance-Based Skills Assessment–Traditional Chinese Version; and (3) functional cognition, measured with the Contextual Memory Test (CMT) and Miami Prospective Memory Test. Secondary outcomes included cognitive functions, anxiety, and depression.
Results: Seventeen participants completed the intervention; 4 missed the follow-up. The generalized estimating equations model showed significant changes from baseline to pretest (control) and pretest to posttest (intervention) on the ADLQ (p = .014) and CMT–delayed (p = .003). Effects remained at the 16-wk follow-up. After adjusting for the effects of covariates, the self-reported daily function of participants ages ≤ 63 yr improved more than that of other participants (p = .003).
Conclusions and Relevance: Multicomponent cognitive interventions integrating LR techniques may improve self-reported daily function and context-dependent memory function of adults with SCD, with efficacy sustained at follow-up.
What This Article Adds: A group-based multicomponent cognitive intervention consisting of cognitive training, cognitive rehabilitation, psychoeducation, and lifestyle intervention may provide benefits for the daily function and cognitive function of adults with SCD.
Risankizumab (Skyrizi)
Authors: CADTH  
Published: August 2023

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses risankizumab (Skyrizi), 600 mg IV infusion for induction therapy at week 0, week 4, and week 8, followed by maintenance therapy with risankizumab 360 mg by subcutaneous injection at week 12 and every 8 weeks thereafter.
Indication: The treatment of adults with moderately to severely active Crohn disease who have an inadequate response, intolerance, or demonstrated dependence to corticosteroids, or an inadequate response, intolerance, or loss of response to immunomodulators or biologic therapies.