bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imputation of missing values for cochlear implant candidate audiometric data and potential applications
Authors: Pavelchek Cole , Michelson Andrew P. , Walia Amit , Ortmann Amanda , Herzog Jacques , Buchman Craig A. , Shew Matthew A. 
Published: February 2023

Objective
Assess the real-world performance of popular imputation algorithms on cochlear implant (CI) candidate audiometric data.

Methods
7,451 audiograms from patients undergoing CI candidacy evaluation were pooled from 32 institutions with complete case analysis yielding 1,304 audiograms. Imputation model performance was assessed with nested cross-validation on randomly generated sparse datasets with various amounts of missing data, distributions of sparsity, and dataset sizes. A threshold for safe imputation was defined as root mean square error (RMSE) <10dB. Models included univariate imputation, interpolation, multiple imputation by chained equations (MICE), k-nearest neighbors, gradient boosted trees, and neural networks.

Results
Greater quantities of missing data were associated with worse performance. Sparsity in audiometric data is not uniformly distributed, as inter-octave frequencies are less commonly tested. With 3–8 missing features per instance, a real-world sparsity distribution was associated with significantly better performance compared to other sparsity distributions (Δ RMSE 0.3 dB– 5.8 dB, non-overlapping 99% confidence intervals). With a real-world sparsity distribution, models were able to safely impute up to 6 missing datapoints in an 11-frequency audiogram. MICE consistently outperformed other models across all metrics and sparsity distributions (p < 0.01, Wilcoxon rank sum test). With sparsity capped at 6 missing features per audiogram but otherwise equivalent to the raw dataset, MICE imputed with RMSE of 7.83 dB [95% CI 7.81–7.86]. Imputing up to 6 missing features captures 99.3% of the audiograms in our dataset, allowing for a 5.7-fold increase in dataset size (1,304 to 7,399 audiograms) as compared with complete case analysis.

Conclusion
Precision medicine will inevitably play an integral role in the future of hearing healthcare. These methods are data dependent, and rigorously validated imputation models are a key tool for maximizing datasets. Using the largest CI audiogram dataset to-date, we demonstrate that in a real-world scenario MICE can safely impute missing data for the vast majority (>99%) of audiograms with RMSE well below a clinically significant threshold of 10dB. Evaluation across a range of dataset sizes and sparsity distributions suggests a high degree of generalizability to future applications.
Fermented dairy foods consumption and depressive symptoms: A meta-analysis of cohort studies
Authors: Luo Yupeng , Li Zhuo , Gu Liya , Zhang Kui 
Published: February 2023

Background
The gut-brain axis has been potentially proposed as a link between the intake of fermented dairy foods and depression. We carried out this meta-analysis on published cohort studies to estimate the overall depression risk of fermented dairy foods intake.

Methods
We searched the CNKI (China National Knowledge Infrastructure) and PubMed databases for all articles within a range of published years from 2010 to 2022 on the association between fermented dairy foods intake and depression.

Results
Finally, 8 studies met the inclusion criteria for this study, with 83,533 participants. Overall, there was statistical evidence of significantly decreased depression risk was found to be associated with fermented dairy foods intake (OR = 0.89, 95% CI = 0.81–0.98). In subgroup analysis, cheese and yogurt consumptions were significantly associated with decreased depression risk (OR = 0.91, 95% CI = 0.84–0.98 for cheese and OR = 0. 84, 95% CI = 0.72–0.99 for yogurt). However, we failed to find superabundant intake of fermented dairy foods intake decreased the risk of depression.

Conclusion
Our meta-analysis indicated that fermented dairy foods intake may have potential beneficial effect on depression via the gut-brain axis.
Oil Powers: A History of the U.S.–Saudi Alliance, Victor McFarland (2020)
Authors: Bukovich Keith 
Published: February 2023

Review of: Oil Powers: A History of the U.S.–Saudi Alliance, Victor McFarland (2020)
New York: Columbia University Press, 384 pp.,
ISBN 978-0-23119-727-4, p/bk, $35.00
Perbedaan Variasi Ketebalan Media Filter Arang Aktif Terhadap Penurunan Kadar Total Dissolved Solids (TDS)
Authors: Wowor Bunga Yunasthania , Hanurawaty Neneng Yety , Yulianto Bambang 
Published: February 2023

Latar belakang: Total Dissolved Solids (TDS) merupakan benda padat terlarut yaitu semua mineral, logam, garam serta anion-kation yang terlarut dalam air. Metode filtrasi dapat menurunkan kadar Total Dissolved Solids (TDS) dan dapat menggunakan media filter arang aktif. Penelitian ini bertujuan untuk mengetahui penurunan kadar Total Dissolved Solids (TDS) dengan perbedaan variasi ketebalan media filter arang aktif.Metode: Penelitian ini bersifat eksperimen dengan desain penelitian pretest-postest without control. Penelitian ini dilakukan dengan 3 perlakuan dan masing-masing perlakuan sebanyak 6 kali pengulangan. Populasi dalam penelitian ini adalah air bersih yang berasal dari sumur di PT. X dengan sampel sebanyak 36 sampel.Hasil: Penurunan kadar Total Dissolved Solids (TDS) pada air bersih menggunakan media filter arang aktif dengan ketebalan 100 cm didapatkan rata–rata 909 mg/l, ketebalan 110 cm didapatkan rata–rata 700,5 mg/l, dan ketebalan 120 cm didapatkan rata–rata 608,8 mg/l.Simpulan: Filter dengan media arang aktif pada tiga ukuran ketebalan yang berbeda efektif menurunkan kadar Total Dissolved Solids (TDS) pada air bersih di Industri Susu X. Peneliti selanjutnya dapat melakukan penelitian lebih lanjut mengenai timelife media filter arang aktif dalam mengadsorpsi kadar Total Dissolved Solids (TDS). ABSTRACTTitle: Differences of Variations in the Thickness of Activated Charcoal Filter Media as Adsorption Media for Filtration Equipment in Reducing Total Dissolved Solids (TDS) Levels in Clean Water in Dairy Industry X, Cinambo District, Bandung CityBackground: Total Dissolved Solids (TDS) are dissolved solids, namely all minerals, metals, salts and anions dissolved in water. Filtration methods can reduce Total Dissolved Solids (TDS) levels and can use activated charcoal filter media. This study aims to determine the decrease in Total Dissolved Solids (TDS) levels with different variations in the thickness of activated charcoal filter media.Method: This research is an experimental research design with pretest-posttest without control. This research was conducted with 3 treatments and each treatment was repeated 6 times. The population in this study is clean water from wells at PT. X with a sample of 36 samples.Result: Reducing Total Dissolved Solids (TDS) levels in clean water using activated charcoal filter media with a thickness of 100 cm obtained an average of 909 mg/l, a thickness of 110 cm obtained an average of 700.5 mg/l, and a thickness of 120 cm obtained an average of an average of 608.8 mg/l. Conclusion: Filters with activated charcoal media at three different thickness sizes are effective according to the levels of Total Dissolved Solids (TDS) in clean water Dairy Industry X. Future researchers can conduct further research regarding the timelife of activated charcoal filter media in adsorption of Total Dissolved Solids (TDS) levels.
Pengembangan Modul Praktikum Fisika Dasar Digital pada Materi Listrik Magnet sebagai Upaya Adaptasi Kebiasaan Baru
Authors: Muttaqin Rodhotul , Setyaningsih Natalia Erna , Nurbaiti Upik 
Published: February 2023

Online practicum is one of the learning solutions during the pandemic but requires adjustments both in terms of material and practicum modules. The purpose of this study was to develop a Digital Fundamental physics Practicum Module on Electromagnetic Materials. The module developed is in the form of a digital module for Fundamental physics Practicum assisted by an integrated practicum video. The Research and Development Model chosen is a 4-D Development Model which has four process stages, namely Define, Design, Development, and Disseminate. The results of the validation of the material experts obtained that the coverage and accuracy aspects of the material obtained a percentage score of 80% and the aspect of material recency received a score of 93%. The results of the validation of linguists found that aspects of language suitability and communicative use of language obtained a percentage score of 93%. In addition, the aspect of using language that stimulates student curiosity has a score of 80%. The results of media expert validation found that the media presented in the digital practicum module had the accuracy of using media in the form of images and videos, aesthetics in images and videos, as well as a clear and systematic description of video interpretation with an average score of 93%. The feasibility test resulted in an average percentage score of 86%, this means that the module is in the very feasible category
Short-term outcomes after simultaneous gastrectomy plus cholecystectomy in gastric cancer: A pooling up analysis
Authors: Kang Bing , Liu Xu-Rui , Peng Dong 
Published: February 2023

AbstractThe purpose of this study was to evaluate the short-term outcomes after simultaneous gastrectomy plus cholecystectomy in gastric cancer patients. PUBMED, EMBASE, and the Cochrane Library were searched from inception to Apr 15, 2021. Short-term surgical outcomes were compared between the simultaneous gastrectomy plus cholecystectomy group and the gastrectomy only group. Five retrospective studies with 3,315 patients and 1 randomized controlled trial with 130 patients were included. There was no significant difference in age, sex, surgical methods, or reconstruction. In terms of short-term outcomes, no significance was found in postoperative complications (odds ratio, OR = 1.08,I2= 24%, 95% CI = 0.78–1.50,P= 0.65), postoperative biliary complications (OR = 0.98,I2= 0%, 95% CI = 0.43–2.25,P= 0.96), mortality (OR = 1.28,I2= 0%, 95% CI = 0.49–3.37,P= 0.61), and postoperative hospital stay (MD = −0.10,I2= 0%, 95% CI = −0.73–0.54,P= 0.77) between the two groups. Simultaneous gastrectomy plus cholecystectomy in gastric cancer patients is safe and does not increase the short-term outcomes.
Ultra-thin grating coupler for guided exciton-polaritons in WS2 multilayers
Authors: Cho HyunHee , Shin Dong-Jin , Sung Junghyun , Gong Su-Hyun 
Published: February 2023

Abstract
An ultra-thin transition metal dichalcogenide (TMDC) layer can support guided exciton-polariton modes due to the strong coupling between excitons and photons. Herein, we report the guided mode resonance in an ultra-thin TMDC grating structure. Owing to the strong exciton resonances in TMDCs, a TMDC grating structure shows guided-mode resonance even at a thickness limit of ∼10 nm and is capable of realizing polaritonic dispersion in a monolithic grating structure. We investigated the polarization and thickness dependence of the optical dispersion relations of the tungsten disulfide (WS2) grating structure. In addition, we confirmed that the monolithic WS2 grating coupler can be used to couple the near-field guided exciton-polariton out into the far field. We believe that ultra-thin TMDC layers can facilitate sub-wavelength nanophotonic applications.
A Meta-analysis of the Effects of High-Intensity Interval Training and Small-Sided Games on Sprint Performance in Adolescents
Authors: Zhang Zhi Yong , Ji Hong Shen , He Jia Xin , Huang Lin Jie , Ding Shi Cong , Sun Jian , Li Duan Ying 
Published: February 2023

ABSTRACT
This study aimed to compare the effects of high-intensity interval training (HIIT) and small-sided games (SSGs) on sprint performance in adolescent athletes in team sports and to provide reference data for training adolescent team-sport athletes. The literature search was performed in PubMed, Web of Science, Scopus, Embase, and SPORTDiscus. Seven eligible articles were selected according to the inclusion and exclusion criteria. HIIT was significantly better than SSGs in the improvement of linear sprint ability (LSA) (standardized mean difference [SMD] = 0.35; p = 0.007). Within-group comparisons showed that both HIIT (SMD = 0.45; p = 0.0007) and SSGs (SMD = 0.27; p = 0.04) effectively improved LSA. There was no significant difference between HIIT and SSGs in the improvement of repeated sprint ability (RSA) (SMD = −0.05; p = 0.77). Within-group comparisons showed no significant differences but a larger effect size of HIIT (SMD = 0.36) than that of SSGs (SMD = 0.17). HIIT is superior to SSGs in improving LSA. Although HIIT is not the best training method for sprint ability, it improves aerobic capacity and speed performance, helping athletes save time and improve training efficiency. HIIT and SSGs have similar training effects on RSA.
FTO negatively regulates the cytotoxic activity of natural killer cells
Authors: Kim Seok‐Min , Oh Se‐Chan , Lee Sun‐Young , Kong Ling‐Zu , Lee Jong‐Hee , Kim Tae‐Don 
Published: February 2023

AbstractN6‐Methyladenosine (m6A) is the most abundant epitranscriptomic mark and plays a fundamental role in almost every aspect of mRNA metabolism. Although m6A writers and readers have been widely studied, the roles of m6A erasers are not well‐understood. Here, we investigate the role of FTO, one of the m6A erasers, in natural killer (NK) cell immunity. We observe that FTO‐deficient NK cells are hyperactivated. Fto knockout (Fto−/−) mouse NK cells prevent melanoma metastasis in vivo, and FTO‐deficient human NK cells enhance the antitumor response against leukemia in vitro. We find that FTO negatively regulates IL‐2/15‐driven JAK/STAT signaling by increasing the mRNA stability of suppressor of cytokine signaling protein (SOCS) family genes. Our results suggest that FTO is an essential modulator of NK cell immunity, providing a new immunotherapeutic strategy for allogeneic NK cell therapies.
Host inflammatory dynamics reveal placental immune modulation by Group B Streptococcus during pregnancy
Authors: Kuperwaser Felicia , Avital Gal , Vaz Michelle J , Noble Kristen N , Dammann Allison N , Randis Tara M , Aronoff David M , Ratner Adam J , Yanai Itai 
Published: February 2023

AbstractGroup B Streptococcus (GBS) is a pathobiont that can ascend to the placenta and cause adverse pregnancy outcomes, in part through production of the toxin β‐hemolysin/cytolysin (β‐h/c). Innate immune cells have been implicated in the response to GBS infection, but the impact of β‐h/c on their response is poorly defined. We show that GBS modulates innate immune cell states by subversion of host inflammation through β‐h/c, allowing worse outcomes. We used an ascending mouse model of GBS infection to measure placental cell state changes over time following infection with a β‐h/c‐deficient and isogenic wild type GBS strain. Transcriptomic analysis suggests that β‐h/c‐producing GBS elicit a worse phenotype through suppression of host inflammatory signaling in placental macrophages and neutrophils, and comparison of human placental macrophages infected with the same strains recapitulates these results. Our findings have implications for identification of new targets in GBS disease to support host defense against pathogenic challenge.
Diabetes Retinopathy Prevalence and Risk Factors among Diabetic Patients Seen at Highland Eye Clinic Mutare Zimbabwe: A Retrospective Study
Authors: Tatenda Lewis Musokeri , Mena Wani , Salissou Maibouge Tanko Mahamane 
Published: February 2023

Objective: To determine the prevalence of diabetic retinopathy and its association with hypertension, age, gender, and fasting blood glucose level.Methods: This retrospective study assessed the prevalence of diabetic retinopathy with its associated risk factors on 135 diabetic patients, aged 18 years and above, visiting the Highland Eye Clinic Mutare, Zimbabwe. Data were collected on the age, sex, and type of retinopathy. Based on the identified retinopathy, subjects were divided into no retinopathy, non-proliferative diabetic renopathy, and proliferative diabetic retinopathy groups. Analysis were then performed using multivariate and univariate regression analyses to test the association between the presence of retinopathy and several risk factors, and results were presented in percentages, with P< 0.05 considered to show statistical significance.Results: The average age of the subjects this study was 60.8 ± 14 with female subjects constituted more than half of the total number of subjects (58.5%). Forty four percent were overweight (BMI 25-30), 34.8 % were obese, and the overall prevalence of diabetic retinopathy was 31.1% (non-proliferative diabetic renopathy, 20%; proliferative renopathy, 11.1%). The proportion of subjects with retinopathy increased with duration of DM, being 23.3% in those with a DM duration of less than 10 years and 46.6% in those with a DM duration of more than 10 years. Age and hypertension were significantly associated with the presence of diabetic retinopathy (P< 0.05) in univariate analysis, but no association was identified between retinopathy and fasting blood glucose (chi-square test, P =0.0965)Conclusion: The prevalence of diabetic retinopathy (DR) is high (31.1%), Non-proliferative DR is more common than the proliferative (DR). There is a strong association between diabetic retinopathy, hypertension, and age.
Development of a system of integrated assessment of efficiency of cardiac care in the Russian Federation regions
Authors: Mikhailov I. A. , Omelyanovsky V. V. , Semenov V. Yu. 
Published: February 2023

Highlights. Methodology for the development of a system of indicators for the integral assessment of effectiveness and efficiency of cardiac care (cardiovascular surgery) in the subjects of the Russian Federation is proposed and tested.Indicators, such as the length of stay, the number of operations on the heart and blood vessels, the number of ambulatory patients have high overall rating and consistency of expert opinions.Aim. To develop a system of indicators for assessment of the effectiveness of cardiac care, cardiovascular surgery in particular, in the Russian Federation regions.Methods. The study using expert surveys was conducted in the form of a structured interview. At the first stage, the primary selection of indicators was carried out using the annual public and field reports of the national medical research center. At the second stage, experts were selected and the level of expert competence was assessed. In total, out of 14 interviewed specialists, 10 were defined as experts. The average expert authority coefficient was 0.89. To quantify the degree of agreement between the experts` answers, Kendall's coefficient of concordance (W) was calculated. The significance of differences was assessed using the nonparametric Friedman test.Results. The following indicators are recommended as indicators for rating efficiency of cardiac care in the regions of the Russian Federation: mortality after heart surgery, vascular surgery and percutaneous coronary interventions; mortality from diseases of the circulatory system; the number of ambulatory patients; the ratio of the number of endovascular interventions to the total number of discharged patients who suffered from acute coronary syndrome.Conclusion. The selected indicators can be used both for the rating of the constituent entities of the Russian Federation, and in the development of federal projects or ministerial target programs. The results of the study can also be used to organize a system for monitoring the effectiveness of the implementation of these projects and programs.
A modern view on the diagnostic role of endothelial dysfunction biomarkers and the possibilities of its correction
Authors: Zakharyan E. A. , Ageeva E. S. , Shramko Yu. I. , Malyi K. D. , Gurtovaya A. K. , Ibragimova R. E. 
Published: February 2023

Highlights. The article presents a review of literature data on the diagnostic role of endothelial dysfunction biomarkers. The review provides an overview of the main indicators, their significance in various pathologies, and presents possible therapeutic strategies for preventing endothelial dysfunction.Abstract. Endothelial dysfunction is a characteristic feature of each stage of the cardiovascular continuum – a series of events from hypertension to the development of atherosclerosis and coronary heart disease, thrombus formation, myocardial infarction, and heart failure. Due to the prominent role of endothelial dysfunction in the pathogenesis of many vascular diseases, it is a significant therapeutic target. It is important to note that circulating markers of endothelial activation and damage characterize the severity of the disease and can be used to evaluate the efficacy of treatment and subsequent prognosis. The purpose of this review is to provide up–to-date data on endothelial function, discussing its clinical relevance in the cardiovascular continuum, the latest insights in molecular and cellular biology, and their implications for clinical practice, with a focus on new methods of therapeutic approaches for correcting endothelial dysfunction.
Minimally invasive aortic valve neocuspidization using autologous pericardium – first experience
Authors: Komarov R. N. , Ismailbev A. M. , Ognev O. O. , Dzyundzya A. N. , Danachev A. O. , Saliba M. B. , Lenkovets M. 
Published: February 2023

Highlights. Conducting minimally invasive aortic valve neocuspidization using autologous pericardium is a difficult task due to pericardial harvesting. Thoracoscopic harvesting of the pericardium provides a pericardial patch of sufficient size under visual control. Thus, thoracoscopic pericardial harvesting can transfer all advantages of minimally invasive cardiac surgery to aortic valve neocuspidization using autologous pericardium.Abstract. Minimally invasive aortic valve (AV) replacement is associated with a decrease in the traumatic nature of the procedure, the length of hospital stay, severity of pain, and provides faster rehabilitation and better cosmetic look compared to the gold standard incision in cardiac surgery –median sternotomy. AV neocuspidization using autologous pericardium is safe, associated with excellent hemodynamic parameters in short- and medium-term follow up. However, this technique requires a large pericardial patch to later form new leaflets, thus complicating the use of minimally invasive approach with this type of intervention. We have addressed this issue by introducing thoracoscopic pericardial harvesting. We report two successful cases of minimally invasive AV neocuspidization using autologous pericardium harvested through a thoracoscopic approach with peripheral cardiopulmonary bypass.