bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obesity, cardiovascular risk, and lifestyle: cross-sectional and prospective analyses in a nationwide Spanish cohort
Authors: Valenzuela Pedro L , Santos-Lozano Alejandro , Saco-Ledo Gonzalo , Castillo-García Adrián , Lucia Alejandro 
Published: June 2023

Abstract

Aims
To assess whether overweight and obesity are independently associated with cardiometabolic health [as categorized based on the presence/absence of cardiovascular disease (CVD) risk factors (diabetes, hypercholesterolaemia, or hypertension)], and the role of lifestyle on this association.

Methods and results
A nationwide cohort of Spanish adults (18–64 years) was studied using a cross-sectional design and prospective observational design. Lifestyle-related factors (physical activity, sleeping characteristics, alcohol drinking, and smoking) were registered, and participants were classified as having an ‘unhealthy’ or ‘healthy’ cardiometabolic status attending to the presence or absence, respectively, of ≥1 CVD risk factor. A number of 596 111 participants (44 ± 9 years, 67% male) were studied at baseline, with prospective analyses in a subcohort [n = 302 061; median follow-up, 2 years (range, 2 to 5)]. Compared to normal weight, overweight and obesity were associated with a higher prevalence [odds ratio, 1.67 (95% confidence interval, 1.61–1.67) and 2.70 (2.69–2.78), respectively] and incidence [1.62 (1.59–1.67) and 2.70 (2.63–2.78)] of an unhealthy cardiometabolic status. Meeting physical activity guidelines reduced the odds of an unhealthy cardiometabolic status at baseline [0.87 (0.85–0.88)] among individuals with overweight/obesity, as well as of transitioning from a healthy status to an unhealthy status during the follow-up [0.87 (0.84–0.94)]. No significant associations were found for the remainder of lifestyle factors.

Conclusion
Overweight and obesity are independently associated with an unhealthy cardiometabolic status. Regular physical activity attenuates not only the prevalence but also the incidence of CVD risk factors.
Utility of Plasma Microbial Cell-Free DNA Whole-Genome Sequencing for Diagnosis of Invasive Aspergillosis in Patients With Hematologic Malignancy or COVID-19
Authors: Lee Ki Hyun , Won Dongju , Kim Jinnam , Lee Jung Ah , Kim Chang Hyup , Kim Jung Ho , Jeong Su Jin , Ku Nam Su , Choi Jun Yong , Yeom Joon-Sup , Cho Hyunsoo , Chung Haerim , Cheong June-Won , Lee Seung-Tae , Jang Ji Eun , Shin Saeam , Ahn Jin Young 
Published: June 2023

Abstract

Background
We evaluated the clinical accuracy and utility of whole-genome sequencing (WGS) of plasma microbial cell-free DNA (cfDNA) as a novel noninvasive method in diagnosing invasive aspergillosis (IA) in patients with hematologic malignancy (HM) or coronavirus disease 2019 (COVID-19).

Methods
Adults with HM or COVID-19 and suspected IA were recruited. IA cases were retrospectively diagnosed according to EORTC/MSG definitions and ECMM/ISHAM criteria for HM and COVID-19 patients, respectively. The results of cfDNA WGS were compared with the conventional diagnosis.

Results
Microbial cfDNA WGS was performed 53 times from 41 participants (19 from HM, 16 from COVID-19, and 7 from the control group). In participants with HM, Aspergillus cfDNA was detected in 100% of proven IA and 91.7% of probable IA cases. In participants with COVID-19, 50.0% of probable IA were positive for Aspergillus in cfDNA WGS. Concordance between Aspergillus cfDNA detection and proven/probable IA conventional diagnosis was significantly higher in participants with HM than in those with COVID-19. IA diagnosed using EORTC/MGS definitions showed significantly high concordance between Aspergillus cfDNA detection and proven/probable IA.

Conclusions
Aspergillus cfDNA detection strongly correlated with proven/probable IA diagnosed using EORTC/MSG definitions and could be used as an additional diagnostic tool for IA.
Impact of kinship support on child mortality in the Upper East Region of Ghana: assessing the Grandmother Hypothesis
Authors: Wak George , Bangha Martin , Aborigo Raymond , Anarfi John , Kwankye Stephen 
Published: June 2023

AbstractBackgroundThe grandmother is an important kin member whose contribution to childcare and survival has been recognized in the literature, hence the Grandmother Hypothesis. This article examines the effect of the presence of a grandmother on child mortality.MethodsData were obtained from the Navrongo Health and Demographic Surveillance System, located in the Upper East Region of Ghana. Children born between January 1999 and December 2018 were included in the analysis. Person-months lived for each child were generated. The multilevel Poisson regression technique was employed to investigate the effect of a grandmother on child survival.ResultsIn all, 57 116 children were included in the analysis, of which 7% died before age 5 y. Person-months were generated for the children, which produced 2.7 million records, with about 487 800 person-years. After controlling for confounders, results showed that children in households with paternal grandmothers are 11% less likely to die compared with those without paternal grandmothers. However, when other confounders were taken into accounts, the beneficial effect of maternal grandmothers disappeared.ConclusionsWe conclude that the presence of grandmothers improves child survival, thus sustaining the Grandmother Hypothesis. The experiences of these grandmothers should be tapped to improve child survival, particularly in rural areas.
An update of the predicted lean yield equation for the Destron PG-100 optical grading probe
Authors: Bohrer Benjamin M , Wang Yifei , Dorleku Justice B , Campbell Cheryl P , Mandell Ira B 
Published: June 2023

Abstract
The objective was to update the equation used for prediction of pork carcass leanness with the Destron PG-100 optical grading probe. A recent cutout study (completed in 2020–2021) consisting of 337 pork carcasses was used for this research. An updated equation was generated using a calibration dataset (N = 188 carcasses) and prediction precision and prediction accuracy of the new equation was evaluated using a validation dataset (N = 149 carcasses). The updated equation was generated using forward stepwise multiple regression selection techniques in PROC REG of SAS, and the same parameters as the existing equation were used to fit the model. The updated Destron equation [89.16298 – (1.63023 × backfat thickness) – (0.42126 × muscle depth) + (0.01930 × backfat thickness2) + (0.00308 × muscle depth2) + (0.00369 × backfat thickness × muscle depth)] and the existing Destron equation [68.1863 – (0.7833 × backfat thickness) + (0.0689 × muscle depth) + (0.0080 × backfat thickness2) – (0.0002 × muscle depth2) + (0.0006 × backfat thickness × muscle depth)] were similar in their prediction precision for determination of carcass lean yield (LY), with the updated equation R2 = 0.75 and root mean square error (RMSE) = 1.97 and the existing equation R2 = 0.75 and RMSE = 1.94. However, when prediction accuracy was evaluated using the variance explained by predictive models based on cross-validation (VEcv) and Legates and McCabe’s efficiency coefficient (E1), the updated equation (VEcv = 67.97%; E1 = 42.41%) was much more accurate compared with the existing equation (VEcv = −117.53%; E1 = −69.24%). Furthermore, when accuracy was evaluated by separating carcasses into 3% carcass LY groupings ranging from less than 50% LY to greater than 62% LY, the existing equation correctly estimated carcass LY 8.1% of the time, while the updated equation correctly estimated carcass LY 47.7% of the time. In an effort to further compare the abilities of the updated equation, comparisons were made with an advanced automated ultrasonic scanner (AutoFom III), which scans the entire carcass. The prediction precision of the AutoFom III was R2 = 0.83 and RMSE = 1.61, while the AutoFom III correctly estimated carcass LY 38.2% of the time and prediction accuracy calculations for the AutoFom III were VEcv = 44.37% and E1 = 21.34%). Overall, refinement of the Destron PG-100 predicted LY equation did not change prediction precision, but substantially improved prediction accuracy.
Evidentialism and Epistemic Duties to Inquire
Authors: McWilliams Emily C 
Published: June 2023

AbstractAre there epistemic duties to inquire? The idea enjoys intuitive support. However, prominent evidentialists argue that our only epistemic duty is to believe well (i.e., to have doxastically justified beliefs), and doing so does not require inquiry. Against this, I argue that evidentialists are plausibly committed to the idea that if we have epistemic duties to believe well, then we have epistemic duties to inquire. This is because on plausible evidentialist views of evidence possession (i.e., views that result in plausible theories of evidentialist justification), inquiry is sometimes a necessary constitutive means of forming doxastically justified beliefs—beliefs that are proportioned to and based on one's evidence. So, either evidentialist views of evidence possession commit them to epistemic duties to inquire or they lead to independently implausible theories of evidentialist justification. My discussion also has important implications for the zetetic turn in epistemology, since I argue that evidentialists who are staunchly opposed to epistemic norms on inquiry have reason to reconsider.
Clinical Utility and Patient Distribution of Brief Resolved Unexplained Event Classification for Apparent Life-Threatening Events
Authors: Tanaka Daiki , Amagasa Shunsuke , Kikuchi Nanae , Sasaki Ryuji , Uematsu Satoko , Tsuji Satoshi , Kubota Mitsuru , Nakagawa Satoshi 
Published: June 2023

Objectives
In 2016, brief resolved unexplained events (BRUEs) were proposed as alternative concepts to apparent life-threatening event (ALTE). The clinical utility of managing ALTE cases according to the BRUE classification is controversial. To verify the clinical utility of the BRUE criteria, we evaluated the proportion of ALTE patients who met and those who did not meet the BRUE criteria and assessed the diagnoses and outcomes of each group.

Methods
We retrospectively investigated patients with ALTE younger than 12 months who visited the emergency department of the National Center for Child Health and Development from April 2008 to March 2020. The patients were classified into the higher-risk and lower-risk BRUE groups; however, those who did not meet the BRUE criteria were classified into the ALTE-not-BRUE group. We evaluated the diagnoses and outcomes of each group. Adverse outcomes included death, recurrence, aspiration, choking, trauma, infection, convulsions, heart disease, metabolic disease, allergies, and others.

Results
Over the period of 12 years, a total of 192 patients were included, among which 140 patients (71%) were classified into the ALTE-not-BRUE group, 43 (22%) into the higher-risk BRUE group, and 9 (5%) into the lower-risk BRUE group. Adverse outcomes occurred in 27 patients in the ALTE-not-BRUE group and 10 patients in the higher-risk BRUE group. No adverse outcome occurred in the lower-risk BRUE group.

Conclusions
Many of the patients with ALTE were classified into the ALTE-not-BRUE group, suggesting that replacing ALTE with BRUE is difficult. Although patients classified as lower-risk BRUE showed no adverse outcomes, there were only a few of them. In the pediatric emergency medicine setting, the BRUE risk classification may be beneficial for certain patients.
Common molecular signatures between coronavirus infection and Alzheimer’s disease reveal targets for drug development
Authors: Abyadeh Morteza , Yadav Vijay K. , Kaya Alaattin 
Published: June 2023

AbstractCognitive decline has been reported as a common consequence of COVID-19, and studies have suggested a link between COVID-19 infection and Alzheimer’s disease (AD). However, the molecular mechanisms underlying this association remain unclear. To shed light on this link, we conducted an integrated genomic analysis using a novel Robust Rank Aggregation method to identify common transcriptional signatures of the frontal cortex, a critical area for cognitive function, between individuals with AD and COVID-19. We then performed various analyses, including the KEGG pathway, GO ontology, protein-protein interaction, hub gene, gene-miRNA, and gene-transcription factor interaction analyses to identify molecular components of biological pathways that are associated with AD in the brain also show similar changes in severe COVID-19. Our findings revealed the molecular mechanisms underpinning the association between COVID-19 infection and AD development and identified several genes, miRNAs, and TFs that may be targeted for therapeutic purposes. However, further research is needed to investigate the diagnostic and therapeutic applications of these findings.
Generative artificial intelligence GPT-4 accelerates knowledge mining and machine learning for synthetic biology
Authors: Xiao Zhengyang , Li Wenyu , Moon Hannah , Roell Garrett W. , Chen Yixin , Tang Yinjie J. 
Published: June 2023

AbstractKnowledge mining from synthetic biology journal articles for machine learning (ML) applications is a labor-intensive process. The development of natural language processing (NLP) tools, such as GPT-4, can accelerate the extraction of published information related to microbial performance under complex strain engineering and bioreactor conditions. As a proof of concept, we used GPT-4 to extract knowledge from 176 publications on two oleaginous yeasts (Yarrowia lipolyticaandRhodosporidium toruloides). After integration with a molecule inventory database, the outcome is a total of 2037 data instances and 28 features, which serve as machine learning inputs. The structured datasets enabled ML approaches (e.g., a random forest model) to predict Yarrowia fermentation titers with high accuracy (R2of 0.86 for unseen test data). Via transfer learning, the trained model could also assess the production capability of the non-conventional yeast,R. toruloides, for which there are fewer published reports. This work demonstrated the potential of generative artificial intelligence to speed up information extraction from research articles, thereby improving design-build-test-learn (DBTL) cycles for commercial biomanufacturing development.
Contact toxicity, antifeedant activity and oviposition preference of osthole against agricultural pests
Authors: Dong Fang , Chen Xin , Xingyuan Men , Li Zhuo , Kong Yujun , Yuan Yiyang , Ge Feng 
Published: June 2023

AbstractOsthole, the dominant bioactive constituent inCnidium monnieri, has been shown to exhibit acute insecticidal activities. However, its detailed toxicity, antifeedant and oviposition preference effects against agricultural pests has not been fully understood, which has greatly hindered its practical applications. This study is designed to investigate the contact toxicity, antifeedant activity and oviposition preference of osthole against three agricultural pests (T. urticae,M. persicaeandB. dorsalis) to evaluate its potential agricultural applications. Our results showed thatCnidium monnieri(L.) Cusson (CMC) have a high osthole content of 11.4 mg/g. Osthole exhibited a comparable level of acute toxicity againstT. urticaeto four other coumarins found in CMC. Osthole demonstrated significant insecticidal activity against first instar nymphs and adults ofT. urticaeandM. persicaein a dose-dependent manner, but not againstB. dorsalisadults. Osthole exposure reduced the fecundity and prolonged the developmental time ofT. urticaeandM. persicae. Leaf choice bioassays revealed potent antifeedant activity inT. urticae. Furthermore, femaleB. dorsalisshowed a distinct preference for laying eggs in mango juice with 0.02 mg/mL osthole at 48 hours, a preference which persisted at 96 hours. These results provide valuable insights into the toxicity, repellent activity, and attractant activity of osthole, thereby contributing to its expanded use in pest control.
Service with a sense of belonging: navigating work–family conflict and emotional irritation in the service efforts of health professionals
Authors: Iqbal Juman , Shagirbasha Shameem , Madhan Kumar P. 
Published: June 2023

PurposeThe service effort behavior (SEB) of health professionals may be impeded by many factors. This study aims to draw upon the conservation of resources and stressor–strain–outcome theories to test a moderated mediation model that explores how work–family conflict (WFC) influences SEB. The mediating effect of emotional irritation (EI) and the moderating effect of organizational identification (OI) was also tested.Design/methodology/approachData was collected over two waves from 524 health professionals working across India and was tested using SPSS PROCESS macros and Amos 24.FindingsThe results revealed that WFC has a significantly negative relationship with SEB, and EI mediates the relationship between the two variables. The mediation process was further moderated by OI.Originality/valueThere is an absolute scarcity of evidence that has explored the association of WFC and SEB with the mediating role of EI. Along with offering a nuanced understanding of these relationships, this study also presents some interesting insights to health-care administrators.
Parents' attending status and alcohol consumption on family cohesion and satisfaction at art festivals
Authors: Liu Yi , Draper Jason , Madera Juan M. , Taylor D. Christopher 
Published: June 2023

PurposeThis study explores the effects of parents' attending status and alcohol consumption (scenario based) on their feelings of happiness, relaxation, family cohesion and family satisfaction.Design/methodology/approachThis study uses a 2 (attending status: with a child or without a child) X 3 (alcohol consumption: water, a cup of beer or four cups of beers) between-subjects experimental design on an art festival and employs relational cohesion theory while spillover theory.FindingsThe results reveal (1) significant differences between parents' attending status on happiness and relaxation; (2) significant differences between alcohol consumption on happiness, family cohesion, and family satisfaction and (3) happiness significantly mediates the effect of parents' alcohol consumption on family cohesion and family satisfaction.Practical implicationsAttending art festivals provides families with a chance to consolidate family relationships. Art festival planners could promote the festival through enhancing participants' family cohesion and satisfaction through potential family leisure activities.Originality/valueEvents are an emerging topic in the hospitality and tourism discipline in recent years. Social impacts, especially family-related outcomes, on art festivals are barely examined. Additionally, while alcohol consumption is common in festivals, the influence of alcohol consumption on the attendees' emotions and behaviors is under-researched.
Are supply chain partnerships developed and implemented according to their potential?
Authors: Enz Matias G. , Lambert Douglas M. 
Published: June 2023

PurposeGrounded in contingency theory and strategic fit theory, the goal for this research was to determine if managers differentiate in terms of the degree of partnership when allocating resources for planning, joint operating controls, communication and other management components to relationships and if this differentiation is based on the Partnership Model (Lambert et al., 1996).Design/methodology/approachIn total, 381 managers representing 31 relationships participated in one-and-a-half-day partnership meetings, and the authors analyzed how the management components were implemented in each relationship compared to the recommendations in the Partnership Model.FindingsManagers did not differentiate types of partnerships which led to over-resourcing relationships with low potential and under-resourcing those with the highest potential for creating value. The principles of contingency theory and strategic fit were not used for managing relationships.Research limitations/implicationsContingency theory combined with the relationship view suggests that management components should not be implemented at the same level for all relationships, but in the 31 relationships studied different partnership types were not managed based on their potential.Practical implicationsThe research reinforces the need for a formal structure like the Partnership Model to establish joint goals for a relationship and guide management in implementation.Originality/valueEffective supply chain management depends on the ability of managers to differentiate among partnership types and fit relational mechanisms that are appropriate. However, researchers tend to generalize their findings to all partnerships regardless of potential. The authors found support for the Partnership Model published in IJLM in 1996 as a method to resource different types of partnerships following the contingency perspective and strategic fit theory.
Two kinds of properties of knowledge networks, knowledge diversity and recombinant innovation: a patent analysis in the wind energy field
Authors: Ju Hailong , Fang Yiting , Zhu Yezhen 
Published: June 2023

Purpose
Prior literature has long argued that knowledge networks contain great opportunities for innovation, and researchers can identify these opportunities using the properties of knowledge networks (PKNs). However, previous studies have examined only the relationship between structural PKNs (s-PKNs) and innovation, ignoring the effect of qualitative PKNs (q-PKNs), which refer to the quality of the relationship between two elements. This study aims to further investigate the effects of q-PKNs on innovation.

Design/methodology/approach
Using a panel data set of 2,255 patents from the Chinese wind energy industry, the authors construct knowledge networks to identify more PKNs and examine these hypotheses.

Findings
The results show that q-PKNs significantly influence recombinant innovation (RI), reflecting the importance of q-PKNs analysed in this study. Moreover, the results suggest that the combinational potential of an element with others may be huge at different levels of q-PKNs.

Originality/value
This study advances the understanding of PKNs and RI by exploring how q-PKNs impact RI. At different levels of PKNs, the potential of the elements to combine with others and form innovation are different. Researchers can more accurately identify the opportunities for RI using two kinds of PKNs. The findings also provide important implications on how government should provide support for R&D firms.