bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orofacial findings and orthodontic treatment conditions in patients with down syndrome – a retrospective investigation
Authors: Möhlhenrich Stephan Christian , Schmidt Peter , Chhatwani Sachin , Kniha Kristian , Tsipkis Alan , Jackowski Joachim , Schulte Andreas G. , Danesh Gholamreza 
Published: May 2023

Abstract
Introduction
The most common chromosomal anomaly is Down syndrome/Trisomy 21, which can be associated with varying degrees of intellectual disability and physical malformation. Specific orofacial characteristics regarding orthodontic treatment options and features are described on the basis of a patient collective from the Witten/Herdecke University, Germany.

Methods
Data of 20 patients (14 boys and 6 girls, mean age: 11.69 ± 3.94 years) who underwent orthodontic treatment between July 2011 and May 2022 were analyzed. Baseline skeletal and dental conditions were assessed, as well as the presence of hypodontia, displacements, and treatment-related root resorptions. The treatment need was evaluated based on the main findings according to the German KIG classification. In addition, treatment success was determined in relation to patient compliance.

Results
The patient group was characterized predominantly by a class III relationship (ΔANB: −2.07 ± 3.90°; ΔWITS: −3.91 ± 4.33 mm) and a brachyfacial cranial configuration (ΔML-NL: −4.38 ± 7.05°, ΔArGoMe: − 8.45 ± 10.06°). The transversal discrepancy of the dental arch width from maxilla to mandible was −0.91 ± 3.44 mm anteriorly and −4.4 ± 4.12 mm posteriorly. Considering the orthodontic indication groups, the most frequent initial finding and treatment indication represented hypodontia (85%), followed by frontal (75%) and unilateral lateral (35%) crossbite. In 55% of the cases, the teeth had a regular shape, but in 35% a generalized and in 15% an isolated hypoplasia. Only 25% of the patients could be treated with a fixed multiband appliance due to sufficient cooperation. In each of these patients, varying degrees of root resorptions were detected during treatment, and 45% of all treatments had to be terminated prematurely due to a lack of cooperation by patients or parents.

Conclusion
The extent of dental and skeletal malformations and the high rate of findings requiring treatment in patients with Down syndrome represent a significant indication for orthodontic therapy, which can be well illustrated by the KIG classification. However, this is in contrast to the eventually increased risk of root resorption, with significantly reduced patient cooperation. A compromised treatment outcome and process must be expected. Consequently, the orthodontic treatment must be simple and realistic to achieve fast and therapeutically satisfactory treatment result.
Culture adaptation for enhanced biogas production from birch wood applying stable carbon isotope analysis to monitor changes in the microbial community
Authors: Hashemi Seyedbehnam , Solli Linn , Lien Kristian M. , Lamb Jacob J. , Horn Svein Jarle 
Published: May 2023

AbstractBirch wood is a potential feedstock for biogas production in Northern Europe; however, the lignocellulosic matrix is recalcitrant preventing efficient conversion to methane. To improve digestibility, birch wood was thermally pre-treated using steam explosion at 220 °C for 10 min. The steam-exploded birch wood (SEBW) was co-digested with cow manure for a period of 120 days in continuously fed CSTRs where the microbial community adapted to the SEBW feedstock. Changes in the microbial community were tracked by stable carbon isotopes- and 16S r RNA analyses. The results showed that the adapted microbial culture could increase methane production up to 365 mL/g VS day, which is higher than previously reported methane production from pre-treated SEBW. This study also revealed that the microbial adaptation significantly increased the tolerance of the microbial community against the inhibitors furfural and HMF which were formed during pre-treatment of birch. The results of the microbial analysis indicated that the relative amount of cellulosic hydrolytic microorganisms (e.g. Actinobacteriota and Fibrobacterota) increased and replaced syntrophic acetate bacteria (e.g. Cloacimonadota, Dethiobacteraceae, and Syntrophomonadaceae) as a function of time. Moreover, the stable carbon isotope analysis indicated that the acetoclastic pathway became the main route for methane production after long-term adaptation. The shift in methane production pathway and change in microbial community shows that for anaerobic digestion of SEBW, the hydrolysis step is important. Although acetoclastic methanogens became dominant after 120 days, a potential route for methane production could also be a direct electron transfer among Sedimentibacter and methanogen archaea.
SOCS1 methylation level is associated with prognosis in patients with acute-on-chronic hepatitis B liver failure
Authors: Li Feng , Zhang Ying , Wang Zhao-Hui , Gao Shuai , Fan Yu-Chen , Wang Kai 
Published: May 2023

Abstract
Background
Glucocorticoids could greatly improve the prognosis of patients with acute-on-chronic hepatitis B liver failure (ACHBLF). Suppressor of cytokine signaling (SOCS) 1 methylation has been shown to be associated with mortality in ACHBLF.

Methods
Eighty patients with ACHBLF were divided into group glucocorticoid (GC) and group conservative medical (CM). Sixty patients with chronic hepatitis B (CHB), and Thirty healthy controls (HCs) served as control group. SOCS1 methylation levels in peripheral mononuclear cells (PBMCs) was detected by MethyLight.

Results
SOCS1 methylation levels were significantly higher in patients with ACHBLF than those with CHB and HCs (P < 0.01, respectively). Nonsurvivors showed significantly higher SOCS1 methylation levels (P < 0.05) than survivors in both GC and CM groups in ACHBLF patients. Furthermore, the survival rates of the SOCS1 methylation-negative group were significantly higher than that of the methylation-positive group at 1 month (P = 0.014) and 3 months (P = 0.003) follow-up. Meanwhile, GC group and CM group had significantly lower mortality at 3 months, which may be related to application of glucocorticoid. In the SOCS1 methylation-positive group, the 1-month survival rate was significantly improved, which may be related to GC treatment (P = 0.020). However, no significant difference could be observed between the GC group and CM group in the methylation-negative group (P = 0.190).

Conclusions
GC treatment could decrease the mortality of ACHBLF and SOCS1 methylation levels might serve as prognostic marker for favorable response to glucocorticoid treatment.
Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging
Authors: Li Yinan , Huang Xiu , Jin Jing , Zhang Haohao , Yang Kai , Han Jingxia , Lv Ying , Sun Yu , Yao Cheng , Lin Tingting , Zhu Caibin , Liu Huijuan 
Published: May 2023

Abstract
Background
Ultraviolet A (UVA) irradiation can lead to skin damage and premature skin aging known as photoaging. This work found that UVA irradiation caused an imbalance between dermal matrix synthesis and degradation through the aberrant upregulation of transgelin (TAGLN) and studied the underlying molecular mechanism.

Results
Co-immunoprecipitation and proximal ligation assay results showed that TAGLN can interact with USP1. USP1 can be retained in the cytoplasm by TAGLN in UVA-induced cells, which inhibits the interaction between USP1/zinc finger E-box binding homeobox 1 (ZEB1), promote the ubiquitination degradation of ZEB1, and lead to photoaging. TAGLN knockdown can release USP1 retention and help human skin fibroblasts (HSFs) resist UVA-induced damage. The interactive interface inhibitors of TAGLN/USP1 were screened via virtual docking to search for small molecules that inhibit photoaging. Zerumbone (Zer), a natural product isolated from Zingiber zerumbet (L.) Smith, was screened out. Zer can competitively bind TAGLN to reduce the retention of USP1 in the cytoplasm and the degradation of ZEB1 ubiquitination in UV-induced HSFs. The poor solubility and permeability of Zer can be improved by preparing it as a nanoemulsion, which can effectively prevent skin photoaging caused by UVA in wild-type (WT) mice. Zer cannot effectively resist the photoaging caused by UVA in Tagln−/− mice because of target loss.

Conclusions
The present results showed that the interaction of TAGLN and USP1 can promote ZEB1 ubiquitination degradation in UV-induced skin photoaging, and Zer can be used as an interactive interface inhibitor of TAGLN/USP1 to prevent photoaging.
Does type of funding affect reporting in network meta-analysis? A scoping review of network meta-analyses
Authors: Veroniki Areti Angeliki , Wong Eric Kai Chung , Lunny Carole , Martinez Molina Juan Camilo , Florez Ivan D. , Tricco Andrea C. , Straus Sharon E. 
Published: May 2023

Abstract
Background
Evidence has shown that private industry-sponsored randomized controlled trials (RCTs) and meta-analyses are more likely to report intervention-favourable results compared with other sources of funding. However, this has not been assessed in network meta-analyses (NMAs).

Objectives
To (a) explore the recommendation rate of industry-sponsored NMAs on their company’s intervention, and (b) assess reporting in NMAs of pharmacologic interventions according to their funding type.

Methods
Design: Scoping review of published NMAs with RCTs.
Information Sources: We used a pre-existing NMA database including 1,144 articles from MEDLINE, EMBASE and Cochrane Database of Systematic Reviews, published between January 2013 and July 2018.
Study Selection: NMAs with transparent funding information and comparing pharmacologic interventions with/without placebo.
Synthesis: We captured whether NMAs recommended their own or another company’s intervention, classified NMAs according to their primary outcome findings (i.e., statistical significance and direction of effect), and according to the overall reported conclusion. We assessed reporting using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension to NMA (PRISMA-NMA) 32-item checklist. We matched and compared industry with non-industry NMAs having the same research question, disease, primary outcome, and pharmacologic intervention against placebo/control.

Results
We retrieved 658 NMAs, which reported a median of 23 items in the PRISMA-NMA checklist (interquartile range [IQR]: 21–26). NMAs were categorized as 314 publicly-sponsored (PRISMA-NMA median 24.5, IQR 22–27), 208 non-sponsored (PRISMA-NMA median 23, IQR 20–25), and 136 industry/mixed-sponsored NMAs (PRISMA-NMA median 21, IQR 19–24). Most industry-sponsored NMAs recommended their own manufactured drug (92%), suggested a statistically significant positive treatment-effect for their drug (82%), and reported an overall positive conclusion (92%). Our matched NMAs (25 industry vs 25 non-industry) indicated that industry-sponsored NMAs had favourable conclusions more often (100% vs 80%) and were associated with larger (but not statistically significantly different) efficacy effect sizes (in 61% of NMAs) compared with non–industry-sponsored NMAs.

Conclusions
Differences in completeness of reporting and author characteristics were apparent among NMAs with different types of funding. Publicly-sponsored NMAs had the best reporting and published their findings in higher impact-factor journals. Knowledge users should be mindful of this potential funding bias in NMAs.
Strategies to improve genomic predictions for 35 duck carcass traits in an F2 population
Authors: Cai Wentao , Hu Jian , Fan Wenlei , Xu Yaxi , Tang Jing , Xie Ming , Zhang Yunsheng , Guo Zhanbao , Zhou Zhengkui , Hou Shuisheng 
Published: May 2023

Abstract
Background
Carcass traits are crucial for broiler ducks, but carcass traits can only be measured postmortem. Genomic selection (GS) is an effective approach in animal breeding to improve selection and reduce costs. However, the performance of genomic prediction in duck carcass traits remains largely unknown.

Results
In this study, we estimated the genetic parameters, performed GS using different models and marker densities, and compared the estimation performance between GS and conventional BLUP on 35 carcass traits in an F2 population of ducks. Most of the cut weight traits and intestine length traits were estimated to be high and moderate heritabilities, respectively, while the heritabilities of percentage slaughter traits were dynamic. The reliability of genome prediction using GBLUP increased by an average of 0.06 compared to the conventional BLUP method. The Permutation studies revealed that 50K markers had achieved ideal prediction reliability, while 3K markers still achieved 90.7% predictive capability would further reduce the cost for duck carcass traits. The genomic relationship matrix normalized by our true variance method instead of the widely used $$\sum {2p}_{i}(1-{p}_{i})$$

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could achieve an increase in prediction reliability in most traits. We detected most of the bayesian models had a better performance, especially for BayesN. Compared to GBLUP, BayesN can further improve the predictive reliability with an average of 0.06 for duck carcass traits.

Conclusion
This study demonstrates genomic selection for duck carcass traits is promising. The genomic prediction can be further improved by modifying the genomic relationship matrix using our proposed true variance method and several Bayesian models. Permutation study provides a theoretical basis for the fact that low-density arrays can be used to reduce genotype costs in duck genome selection.
Children and adolescents coping with home isolation and social distancing during Covid-19 in Qatar: a cross sectional study with qualitative items
Authors: Zainel Abduljaleel Abdullatif , Daher-Nashif Suhad , Al-Maadeed Alyaa Nasser , Qotba Hamda Abdulla , Al Mujalli Hanan , Al-Kohji Sadriya Mohd 
Published: May 2023

Abstract
Background
Covid-19 related studies report psychological impacts during home isolation and social distancing. Despite that, children and adolescents were able to adopt coping strategies that assisted in lowering severe levels of psychological disorders. This study aims to report on the psychosocial implications of social distancing and isolation on children of different nationalities who reside in Qatar, and to reveal their coping ways.

Methods
This is a cross sectional study with qualitative component at its end. The study is a part of a larger study that reported the results of a national screening for psychological disorders experienced by children and adolescents in Qatar. A bilingual online questionnaire included close-ended and one open-ended question to screen for psychological changes and identify coping strategies practiced by children and adolescents (7–18 years) during home-isolation and social distancing. The quantitative questionnaire had five main sections as follows: the sociodemographic characteristics, Spence Children’s Anxiety Scale, Kutcher Adolescent Depression Scale, and Clinical Anger Scale). The last section screened for eight different coping strategies. The summative content analysis was used to analyze the open-ended question “What practices do you do at home that make you happy?”. First, open coding was used (for identification), followed by the axial coding (for comparison), and lasted by sorting of coping strategies inductively.

Results
Six thousand six hundred and eight (6608) subjects participated between June 23 and July 18, 2020. The clinical outcomes of the study had varying prevalence and levels of severity, which ranged from mild to severe. Higher prevalence was noted for adjustment disorder 66.5% (n = 4396), and generalized anxiety 60% (n = 3858), in comparison to depression 40% (n = 2588). Additionally, participants reported using cognitive, spiritual, social, and physical coping strategies. Eight higher order themes were identified to reflect the coping strategies: playing with siblings or pets, gardening, cooking, practicing arts and crafts, and doing chores. Furthermore, Sociodemographic factors such as ethnicity, religion and family status played a considerable role in choosing the type of coping strategy.

Conclusion
The uniqueness of the study is bringing the psychosocial implications of social distancing through the voices of children and adolescents, and coping strategies from their perspective. These results are of importance for educational and healthcare systems that are recommended to collaborate even in “normal” times to prepare these age categories for any future crises. The importance of daily lifestyle and family is highlighted as protectors, and crucial factors in emotional management.
New cell sources for CAR-based immunotherapy
Authors: Mazinani Marzieh , Rahbarizadeh Fatemeh 
Published: May 2023

AbstractChimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in preclinical and clinical trials, resulting in six FDA-approved CAR-T products currently available in the market. Despite impressive clinical outcomes, concerns about treatment failure associated with low efficacy or high cytotoxicity of CAR-T cells remain. While the main focus has been on improving CAR-T cells, exploring alternative cellular sources for CAR generation has garnered growing interest. In the current review, we comprehensively evaluated other cell sources rather than conventional T cells for CAR generation.
Exploration of issues, challenges and latest developments in autonomous cars
Authors: Padmaja B. , Moorthy CH. V. K. N. S. N. , Venkateswarulu N. , Bala Myneni Madhu 
Published: May 2023

AbstractAutonomous cars have achieved exceptional growth in the automotive industry in the last century in terms of reliability, safety and affordability. Due to significant advancements in computing, communication and other technologies, today we are in the era of autonomous cars. A number of prototype models of autonomous cars have been tested covering several miles of test drives. Many prominent car manufacturers have started investing huge resources in this technology to make it commercialize in the near future years. But to achieve this goal still there are a number of technical and non-technical challenges that exist in terms of real-time implementation, consumer satisfaction, security and privacy concerns, policies and regulations. In summary, this survey paper presents a comprehensive and up-to-date overview of the latest developments in the field of autonomous cars, including cutting-edge technologies, innovative applications, and testing. It addresses the key obstacles and challenges hindering the progress of autonomous car development, making it a valuable resource for anyone interested in understanding the current state of the art and future potential of autonomous cars.
Threshold optimization and random undersampling for imbalanced credit card data
Authors: Leevy Joffrey L. , Johnson Justin M. , Hancock John , Khoshgoftaar Taghi M. 
Published: May 2023

AbstractOutput thresholding is well-suited for addressing class imbalance, since the technique does not increase dataset size, run the risk of discarding important instances, or modify an existing learner. Through the use of the Credit Card Fraud Detection Dataset, this study proposes a threshold optimization approach that factors in the constraint True Positive Rate (TPR) ≥ True Negative Rate (TNR). Our findings indicate that an increase of the Area Under the Precision–Recall Curve (AUPRC) score is associated with an improvement in threshold-based classification scores, while an increase of positive class prior probability causes optimal thresholds to increase. In addition, we discovered that best overall results for the selection of an optimal threshold are obtained without the use of Random Undersampling (RUS). Furthermore, with the exception of AUPRC, we established that the default threshold yields good performance scores at a balanced class ratio. Our evaluation of four threshold optimization techniques, eight threshold-dependent metrics, and two threshold-agnostic metrics defines the uniqueness of this research.
Explaining tourist revisit intention using natural language processing and classification techniques
Authors: Gregoriades Andreas , Pampaka Maria , Herodotou Herodotos , Christodoulou Evripides 
Published: May 2023

AbstractRevisit intention is a key indicator of business performance, studied in many fields including hospitality. This work employs big data analytics to investigate revisit intention patterns from tourists’ electronic word of mouth (eWOM) using text classification, negation detection, and topic modelling. The method is applied on publicly available hotel reviews that are labelled automatically based on consumers’ intention to revisit a hotel or not. Topics discussed in revisit-annotated reviews are automatically extracted and used as features during the training of two Extreme Gradient Boosting models (XGBoost), one for each of two hotel categories (2/3 and 4/5 stars). The emerging patterns from the trained XGBoost models are identified using an explainable machine learning technique, namely SHAP (SHapley Additive exPlanations). Results show how topics discussed by tourists in reviews relate with revisit/non revisit intention. The proposed method can help hoteliers make more informed decisions on how to improve their services and thus increase customer revisit occurrences.
Ectopic recurrence craniopharyngioma: series report and literature review
Authors: Ji Chenxing , Cheng Haixia , Zhou Xiang , Cao Xiaoyun , Qiao Nidan , Shi Chengzhang , Zhang Yichao , Ye Zhao , Zhao Yao 
Published: May 2023

Abstract
Background
Craniopharyngioma is a common intracranial tumor located in the sellar-suprasellar region. Due to the involvement of adjacent structures, it can lead to increased intracranial pressure, visual impairment, and endocrine deficiencies. Surgical resection is the primary treatment, but it is a tough challenge to achieve total resection, which will led to the frequency of recurrences and progressions. Among them, distant spread is extremely rare, but important complication, identifying and providing proper therapy, is crucial.

Methods
We report two cases of ectopic recurrence craniopharyngioma and make a literature review for the published similar case reports.

Results
Our literature review revealed 63 cases (including our patient). The onset age in children group and adult group ranges from 2–14 years old (6.70 ± 3.33) to 17–73 years old (40.63 ± 15.58), while the interval year between tumor initiation and ectopic recurrence ranges from 0.17–20 (7.28 ± 6.76) years to 0.3–34 (6.85 ± 7.29). Achieving gross total resection seems not to prevent the ectopic recurrence. The major pathology of ectopic recurrence craniopharyngioma is adamantinomatous type. The most common site of ectopic recurrence is frontal lobe. According to the pathogenesis, 35 cases were seeding along the surgical approach, and 28 cases were seeding via the CSF pathway.

Conclusion
Ectopic recurrence craniopharyngioma is rare, but it can lead to serious symptoms. Delicate surgical procedure can help to reduce the risk of ectopic recurrence, and standardized follow-up can provide valuable information for treatment.