bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of idiopathic nephrotic syndrome during the Covid-19 pandemic in the Paris area (France) and in the Netherlands
Authors: Veltkamp Floor , Thenot Victoire , Mussies Carlijn , van Lieshout Bas , Peters-Sengers Hessel , Kers Jesper , Khan Djera H. , Hogan Julien , Florquin Sandrine , Bouts Antonia H. M. , Dossier Claire ,   on behalf of the NEPHROVIR network, the LEARNS consortium
Published: May 2023

Abstract
Background
The aetiology of idiopathic nephrotic syndrome (INS) remains partially unknown. Viral infections have been associated with INS onset. Since we observed fewer first onset INS cases during the Covid-19 pandemic, we hypothesised that lower INS incidence was the result of lockdown measures. Therefore, the aim of this study was to evaluate the incidence of childhood INS before and during the COVID-19 pandemic in two independent European INS cohorts.

Methods
Children with new INS in the Netherlands (2018–2021) and Paris area (2018–2021) were included. We estimated incidences using census data for each region. Incidences were compared using two proportion Z-tests.

Results
A total of 128 and 324 cases of first onset INS were reported in the Netherlands and Paris area, respectively, corresponding to an annual incidence of 1.21 and 2.58 per 100,000 children/year. Boys and young children (< 7 years) were more frequently affected. Incidence before and during the pandemic did not differ. When schools were closed, incidence was lower in both regions: 0.53 vs. 1.31 (p = 0.017) in the Netherlands and 0.94 vs. 2.63 (p = 0.049) in the Paris area. During peaks of hospital admissions for Covid-19, no cases were reported in the Netherlands or Paris area.

Conclusions
Incidence of INS before and during the Covid-19 pandemic was not different, but when schools were closed during lockdown, incidence was significantly lower. Interestingly, incidences of other respiratory viral infections were also reduced as was air pollution. Together, these results argue for a link between INS onset and viral infections and/or environmental factors.

Graphical abstract
Symptom burden survey and symptom clusters in patients with cervical cancer: a cross-sectional survey
Authors: Zhou Kai-nan , Wang Yan , Xie Yi , Yang Shu-han , Liu Su-ying , Fang Yu-hang , Zhang Ying 
Published: May 2023

Abstract
Purpose
The purpose of this study is to determine the incidence and severity of symptoms of patients with cervical cancer within 6 months after radiotherapy and chemotherapy, form a symptom burden report, evaluate the distribution characteristics of symptoms, identify symptom clusters, and provide a basis for clinical doctors and nurses to improve the symptom management of patients with cervical cancer after radiotherapy and chemotherapy.

Methods
The patients with cervical cancer within 6 months after radiotherapy and chemotherapy were recruited to investigate their symptom burden. Exploratory factor analysis was used to identify symptom clusters.

Results
A total of 250 patients participated in the study. The study found that the most common symptom among the 40 symptoms was fatigue, and the most serious symptom was nocturia. Based on the occurrence rate and severity of symptoms, nine symptom clusters were identified, including psycho–emotion-related symptom cluster, pain–disturbed sleep-related symptom cluster, menopausal symptom cluster, tinnitus–dizziness-related symptom cluster, urinary-related symptom cluster, dry mouth–bitter taste-related symptom cluster, intestinal-related symptom cluster, memory loss–numbness-related symptom cluster, and emaciation-related symptom cluster. The three most serious symptom clusters are pain–disturbed sleep-related symptom cluster, urinary-related symptom cluster, and memory loss–numbness-related symptom cluster.

Conclusion
The symptoms of patients with cervical cancer within 6 months after radiotherapy and chemotherapy are complex, and nine symptom clusters can be identified according to the incidence and severity of symptoms. We can find the potential biological mechanism of each symptom cluster through the discussion of previous mechanism research and clinical research. The number of symptom clusters and the number of symptoms within the symptom cluster are closely related to the symptom evaluation scale selected for the study. Therefore, the symptom cluster study urgently needs a targeted symptom evaluation scale that can comprehensively reflect the patient’s condition.
Efficacy in urinary symptom burden, psychological distress, and self-efficacy of education-enhanced interventions in prostate cancer patients: a systematic review and meta-analyses
Authors: Martín-Núñez Javier , Raya-Benítez Julia , López-López Laura , Calvache-Mateo Andrés , Heredia-Ciuró Alejandro , Navas-Otero Alba , Valenza Marie Carmen 
Published: May 2023

Abstract
Background
Worldwide, prostate cancer is both the second-most diagnosed cancer and most common solid tumor in men. Prostate cancer patients present with a symptom burden that is compounded by the impact of medical oncology treatment, affecting different domains of their perceived health status. Education active techniques are a key role in chronic disease to increase participation in their recovery.

Purpose
The purpose of the current review was to examine the efficacy of education-enhanced in urinary symptom burden, psychological distress, and self-efficacy in patients diagnosed with prostate cancer.

Methods
A wide search of the literature was conducted for articles from their inception to June 2022. Only randomized controlled trials were included. Data extraction and methodologic quality assessment of the studies were carried out by two reviewers. We previously registered the protocol of this systematic review on PROSPERO (CRD42022331954).

Results
A total of six studies were included in the study. After education-enhanced intervention showed significant improvements in any of perceived urinary symptom burden, one in psychological distress, and one in self-efficacy in the experimental group. The meta-analysis showed that education-enhanced interventions have a significant effect on depression.

Conclusion
Education-enhanced could have positive effects on urinary symptom burden, psychological distress, and self-efficacy in prostate cancer survivors. Our review was unable to demonstrate the best timing to apply education-enhanced strategies.
Best-response planning for urban fleet coordination
Authors: Martí Pasqual , Jordán Jaume , Julian Vicente 
Published: May 2023

AbstractThe modeling of fleet vehicles as self-interested agents brings a realistic perspective to open fleet transportation research. This feature allows us to model the fleet operation from a non-cooperative point of view. In this work, we study parcel delivery in a city with limited resources (roads and charging stations). We designed and implemented a system composed of a multi-agent planner and a game-theoretic coordination algorithm: a Best-Response Fleet Planner. The system allows for the self-organization of the transportation system by coordinating a fleet of self-interested electric vehicles. The system’s operation is optimized together with resource usage while preserving the agents’ private interests, allowing each agent to plan its actions. The results show that our system has higher scalability than similar approaches, allowing it to function for a considerable number of agents in settings that feature congestion and conflicts. Additionally, overall solution quality is improved compared to other coordination systems, reducing congestion and avoiding unnecessary waiting times.
The shortage of surgeons in Japan: Results of an online survey of qualified teaching hospitals that take part in the surgical training programs for board certification by the Japan Surgical Society
Authors: Takami Hideki , Kodera Yasuhiro , Eguchi Hidetoshi , Kitago Minoru , Murotani Kenta , Hirano Satoshi , Kitagawa Yuko , Ikeda Norihiko , Mori Masaki 
Published: May 2023

Abstract
Purpose
A collapse in regional healthcare through the maldistribution of physicians has been a long-debated issue in Japan and amidst this situation, a new system of board certification was initiated. The Japan Surgical Society (JSS) conducted a nation-wide survey to grasp the current distribution of surgeons in Japan, and their roles.

Methods
All 1976 JSS-certified teaching hospitals were invited to respond to a web-based questionnaire. The responses were analyzed to seek a solution to the current issues.

Results
Responses to the questionnaire were received from 1335 hospitals. The surgical departments of medical universities serve as an internal labor market and were the source of surgeons for most hospitals. More than 50% of teaching hospitals throughout the country claimed a shortage of surgeons even in well-populated prefectures such as Tokyo and Osaka. Hospitals rely on surgeons to cover the deficits in medical oncology, anesthesiology, and emergency medicine. These additional responsibilities were identified as significant predictors of a shortage of surgeons.

Conclusions
Surgeon shortage is a serious issue throughout Japan. Given the limited number of surgeons and surgical trainees, hospitals should make every effort to recruit specialists in the additional fields where surgeons are filling the gaps and allow surgeons to engage more in surgery.
Surgical management of Warthin tumor: long-term follow-up of 224 patients from 2002 to 2018
Authors: Bonavolontà Paola , Germano Cristiana , Committeri Umberto , Orabona Giovanni Dell’Aversana , Piombino Pasquale , Abbate Vincenzo , Maglitto Fabio , Iaconetta Giorgio , Califano Luigi 
Published: May 2023

Abstract

Purpose
Warthin tumors (WT) are the second most common benign parotid gland neoplasms. They can occur as synchronous or metachronous lesions in 6–10% of cases. This study aims to compare the complication rate in 224 patients who underwent extracapsular dissection (ECD) or superficial parotidectomy (SP) for the treatment of a WT.

Methods
This retrospective study was conducted at the Department of Maxillo-Facial Surgery at the University of Naples “Federico II” from February 2002 to December 2018 on a group of patients who underwent surgical treatment for WT. The type of surgical technique was chosen based on Quer’s classification. The complications evaluated were facial nerve palsy, hematoma, Frey’s syndrome, and bleeding.

Results
A total of 224 patients treated from 2002 to 2018 for Warthin tumor were included in the study. Two hundred elven had solitary tumors (94.1%) and 13 had multicentric lesions (5.8%), of which 9 cases presented synchronous lesions and 4 cases presented metachronous lesions. Extracapsular dissection (ECD) was performed in 130 patients (58.3% of cases) and superficial parotidectomy (SP) in the other 94 (41.7% of cases).

Conclusions
We consider both surgical techniques as valid. In our opinion, it is essential to study each case based on Quer’s Classification to obtain the best surgical outcome. Based on a lower observed rate of complications such as facial nerve palsy, Frey’s syndrome, and bleeding, ECD seems to be the best option for the surgical treatment of Quer Class I lesions.
The whole genomic analysis of the Orf virus strains ORFV-SC and ORFV-SC1 from the Sichuan province and their weak pathological response in rabbits
Authors: Du Guoyu , Wu Jinyan , Zhang Cheng , Cao Xiaoan , Li Lingxia , He Jijun , Zhang Yong , Shang Youjun 
Published: May 2023

AbstractThe Orf virus (ORFV) is a member of the Parapoxvirus genus of the Poxviridae family and can cause contagious diseases in sheep, goats, and wild ungulates. In the present study, two ORFV isolates (ORFV-SC isolated from Sichuan province and ORFV-SC1 produced by 60 passages of ORFV-SC in cells) were sequenced and compared to multiple ORFVs. The two ORFV sequences had entire genome sizes of 14,0707 bp and 141,154 bp, respectively, containing 130 and 131 genes, with a G + C content of 63% for the ORFV-SC sequence and 63.9% for the ORFV-SC1 sequence. Alignment of ORFV-SC and ORFV-SC1 with five other ORFV isolates revealed that ORFV-SC, ORFV-SC1, and NA1/11 shared > 95% nucleotide identity with 109 genes. Five genes (ORF007, ORF20, ORF080, ORF112, ORF116) have low amino acids identity between ORFV-SC and ORFV-SC1. Mutations in amino acids result in changes in the secondary and tertiary structure of ORF007, ORF020, and ORF112 proteins. The phylogenetic tree based on the complete genome sequence and 37 single genes revealed that the two ORFV isolates originated from sheep. Finally, animal experiments demonstrated that ORFV-SC1 is less harmful to rabbits than ORFV-SC. The exploration of two full-length viral genome sequences provides valuable information in ORFV biology and epidemiology research. Furthermore, ORFV-SC1 demonstrated an acceptable safety profile following animal vaccination, indicating its potential as a live ORFV vaccine.
Acceptability, access, and uptake of human papillomavirus vaccination in mental health populations: a scoping review
Authors: King Keith D. , Fernandez-Sanchez Higinio , MacDonald Shannon E. 
Published: May 2023

Abstract
Aim
The purpose of this study is to describe the scope, breadth, and depth of the existing literature on the acceptability of, access to, and uptake of HPV vaccine in mental health populations.

Subject and methods
Human papillomavirus (HPV) is responsible for significant cancer morbidity and mortality. Effective vaccines are available; however, uptake is suboptimal. Mental disorders are common, and people with mental disorders are known to have lower rates of cancer screening and reduced uptake of preventive health measures than the general population. This scoping review involved a comprehensive search of published literature. Two independent reviewers screened articles in duplicate and extracted data. Data were analyzed and mapped using quantification of study characteristics.

Results
There were 16 quantitative studies included, all conducted in high-resource countries. Studies were focused on youth and adolescents (n = 8), youth and adults (n = 3), or adults (n = 5); and explored substance use disorder (n = 9), mental disorders such as anxiety, depression or others (n = 6), or developmental/intellectual disabilities (n = 4). One study looked at gender identity disorder. There were studies about access to (n = 4), acceptability of (n = 4), and uptake of (n = 13) HPV vaccination. No studies described a theoretical approach to their work.

Conclusion
There is limited research available on the relationship between mental health and HPV vaccination acceptability, access, or uptake. Efforts should be made to extend both quantitative and qualitative literature in this area, including using theoretical frameworks to improve the transferability of research into practice.
FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation
Authors: Mieczkowski Kamil , Popeda Marta , Lesniak Dagmara , Sadej Rafal , Kitowska Kamila 
Published: May 2023

AbstractThe role of fibroblast growth factor receptor 2 (FGFR2), an important mediator of stromal paracrine and autocrine signals, in mammary gland morphogenesis and breast cancer has been extensively studied over the last years. However, the function of FGFR2 signalling in the initiation of mammary epithelial oncogenic transformation remains elusive. Here, FGFR2-dependent behaviour of nontumorigenic model of mammary epithelial cells was studied. In vitro analyses demonstrated that FGFR2 regulates epithelial cell communication with extracellular matrix (ECM) proteins. Silencing of FGFR2 significantly changed the phenotype of cell colonies in three-dimensional cultures, decreased integrins α2, α5 and β1 protein levels and affected integrin-driven processes, such as cell adhesion and migration. More detailed analysis revealed the FGFR2 knock-down-induced proteasomal degradation of integrin β1. Analysis of RNA-seq databases showed significantly decreased FGFR2 and ITGB1 mRNA levels in breast tumour samples, when compared to non-transformed tissues. Additionally, high risk healthy individuals were found to have disrupted correlation profiles of genes associated with FGFR2 and integrin signalling, cell adhesion/migration and ECM remodelling. Taken together, our results strongly suggest that FGFR2 loss with concomitant integrin β1 degradation is responsible for deregulation of epithelial cell-ECM interactions and this process may play an important role in the initiation of mammary gland epithelial tumorigenesis.
Structural Properties of Gibbsian Point Processes in Abstract Spaces
Authors: Betsch Steffen 
Published: May 2023

AbstractIn the language of random counting measures, many structural properties of the Poisson process can be studied in arbitrary measurable spaces. We provide a similarly general treatise of Gibbs processes. With the GNZ equations as a definition of these objects, Gibbs processes can be introduced in abstract spaces without any topological structure. In this general setting, partition functions, Janossy densities, and correlation functions are studied. While the definition covers finite and infinite Gibbs processes alike, the finite case allows, even in abstract spaces, for an equivalent and more explicit characterization via a familiar series expansion. Recent generalizations of factorial measures to arbitrary measurable spaces, where counting measures cannot be written as sums of Dirac measures, likewise allow to generalize the concept of Hamiltonians. The DLR equations, which completely characterize a Gibbs process, as well as basic results for the local convergence topology, are also formulated in full generality. We prove a new theorem on the extraction of locally convergent subsequences from a sequence of point processes and use this statement to provide existence results for Gibbs processes in general spaces with potentially infinite range of interaction. These results are used to guarantee the existence of Gibbs processes with cluster-dependent interactions and to prove a recent conjecture concerning the existence of Gibbsian particle processes.
cDNA Cloning, Heterologous Expression, Cytotoxicity, and Inhibitory Effects of a Disintegrin from Bothrops ammodytoides Venom
Authors: Clement Herlinda , Corrales-García Ligia Luz , Rivas-Mercado Eric , Garza-Ocañas Lourdes , Corzo Gerardo 
Published: May 2023

AbstractAn mRNA transcript that codes for a Disintegrin and a Metalloprotease from a venom gland of the viper Bothrops ammodytoides was isolated. Vector pCR®2.1-TOPO was used to clone the Disintegrin transcript and then subcloned in the pET-28a vector to express the protein in the E. coli strain BL21. The recombinant disintegrin, HisrDisintegrin, comprises 38 residues at the N-terminal and 75 residues of the Disintegrin, including 14 cysteines or 7 disulfide bonds. HisrDisintegrin was obtained soluble in the intracellular fraction and separated by affinity chromatography. The experimental molecular mass of HisrDisintegrin, 11,750.8 Da, agreed with its theoretical value, including the cleavage of a Met residue caused by a bacterial post-translational modification. HisrDisintegrin was folded in in vitro conditions and then purified, finding a main fraction with a comparable molecular mass. The HisrDisintegrin contains an alpha/beta structure, as observed by circular dichroism. Its biological activity demonstrated the growth reduction of the human endothelial (HMEC-1) cells and the human mammary gland adenocarcinoma (MDA-MB-231). Furthermore, HisrDisintegrin inhibits the adhesion of HMEC-1 and MDA-MB-231 cells to the proteins of the extracellular matrix (laminin (LN), fibronectin (FN), and vitronectin (VN)).
First insight into microplastic groundwater pollution in Latin America: the case of a coastal aquifer in Northwest Mexico
Authors: Alvarado-Zambrano Daniela , Rivera-Hernández José R. , Green-Ruiz Carlos 
Published: May 2023

Abstract
Microplastics have been studied on biota and other environmental domains, such as soils. Despite the importance of groundwater as a resource for millions of people worldwide as drinking water and personal hygiene, domestic, agricultural, mining, and industrial purposes, there are very few studies concerning microplastics in this domain around the world. We present the first study in Latin America addressing this topic. Six capped boreholes were analyzed in terms of abundance, concentration, and chemical characterization, at three different depths, from a coastal aquifer in Northwest Mexico. This aquifer is highly permeable and affected by anthropogenic activities. A total of 330 microplastics were found in the eighteen samples. In terms of concentration, the interval ranged from 10 to 34 particles/L, with an average of 18.3 particles/L. Four synthetic polymers were identified: isotactic polypropylene (iPP), hydroxyethylcellulose (HEC), carboxylated polyvinyl chloride (PVC), and low-density polyethylene (LDPE); with iPP being the most abundant (55.8%) in each borehole. Agriculture activities and septic outflows are considered the potential regional sources of these contaminants into the aquifer. Three possible transport pathways to the aquifer are suggested: (1) marine intrusion, (2) marsh intrusion, and (3) infiltration through the soil. More research about the occurrence, concentration, and distribution of the different kinds of microplastics in groundwater is needed to have a better understanding of the behavior and health risks to organisms, including human beings.
Students’ preferences with university teaching practices: analysis of testimonials with artificial intelligence
Authors: Álvarez-Álvarez Carmen , Falcon Samuel 
Published: May 2023

AbstractUniversity teaching practices impact student interest, engagement, and academic performance. This paper presents a study that uses artificial intelligence (AI) to examine students’ preferences for university teaching practices. We asked students in various fields open-ended questions about the best teaching practices they had experienced. Due to the large amount of data obtained, we used the AI-based language model Generative Pretrained Transformer-3 (GPT-3) to analyse the responses. With this model, we sorted students’ testimonies into nine theory-based categories regarding teaching practices. After analysing the reliability of the classifications conducted by GPT-3, we found that the agreement between humans was similar to that observed between humans and the AI model, which supported its reliability. Regarding students’ preferences for teaching practices, the results showed that students prefer practices that focus on (1) clarity and (2) interaction and relationships. These results enable the use of AI-based tools that facilitate the analysis of large amounts of information collected through open methods. At the didactic level, students’ preferences and demand for clear teaching practices (in which ideas and activities are stated and shown without ambiguity) that are based on interaction and relationships (between teachers and students and among students themselves) are demonstrable.