bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adultos mayores: sus prioridades diferenciadas en áreas rurales y urbanas en una población mexicana
Authors: Amador Licona Norma , Guízar Mendoza Juan Manuel 
Published: June 2023

Aunque múltiples países en Latinoamérica han firmado la Convención Interamericana sobre la Protección de los Derechos Humanos de las Personas Mayores, aún falta mucho por hacer en esta población. El objetivo de este trabajo es conocer las necesidades actuales que expresan los adultos mayores tanto en el área urbana como rural en una población de México. Mediante la realización de 5 grupos focales (3 en el área urbana y 2 en la rural), junto con la asignación de prioridad de las necesidades identificadas mediante un cuestionario auto-aplicable y anónimo, se identificó que, la necesidad considerada en primer lugar fue la atención en salud, seguido de adecuaciones en la vivienda propias para adultos mayores en todo el grupo. Las necesidades de cultura/diversión y apoyo administrativo, aunque no alcanzaron diferencia significativa en la priorización, la primera presentó tendencia a ser más prioritaria para el área urbana y la segunda para la rural. El ejercicio, capacitación/desarrollo y apoyo legal se identificaron con mayor prioridad en el área rural que en la urbana. La necesidad de vestido se identificó en los últimos lugares de prioridad sin diferencia de selección entre los grupos.
Association of Body Mass Index and Abdominal Obesity with Incidence of Atrial Fibrillation in Heart Failure with Preserved Ejection Fraction
Authors: Huang Xinyi , Liu Xiao , Jiang Yuan , Cao Zhengyu , Wu Maoxiong , Chen Zhiteng , Sun Runlu , Yu Peng , Ma Jianyong , Zhu Wengen , Chen Yangxin , Wu Guifu , Zhang Yuling , Wang Jingfeng 
Published: June 2023

Introduction:
The association between obesity and atrial fibrillation (AF) incidence in
heart failure with preserved ejection fraction (HFpEF) patients is currently unclear. Our analyses
and results are based on the whole Treatment of Preserved Cardiac Function Heart Failure with an
Aldosterone Antagonist (TOPCAT) trial (placebo and spironolactone).

Methods:
A total of 2138 subjects without baseline AF were included in the trial. Kaplan-Meier
(K-M) curves and Cox regression with hazard ratios (HRs) and confidence intervals (CIs) were
used to assess the incidence of AF with obesity.

Results:
Of 2138 HFpEF patients without baseline AF, 1165 were obese (body mass index [BMI]≥
30 kg/m2). The K-M curve showed obese patients developed AF more than overweight (25≤
BMI ≤29.9 kg/m2) patients (p=0.013), confirmed by multivariable analysis, while there’s no statistical
difference between overweight and normal weight (18.5≤ BMI ≤24.9 kg/m2) patients. The occurrence
of AF increased by 3% for every kg/m2 increase in BMI (adjusted HR, aHR: 1.03; 95%
CI: 1.00-1.06), with a positive linear association (p for nonlinear: 0.145). Obesity was associated
with AF incidence (aHR: 1.62; 95% CI: 1.05-2.50) compared with non-obesity (including overweight
and normal-weight patients). Abdominal obesity was associated with increased AF incidence
(aHR: 1.70; 95% CI: 1.04-2.77), and AF incidence rose by 18% per centimeter in circumference
(aHR: 1.18; 95% CI:1.04-1.34).

Conclusion:
Obesity and abdominal obesity increase the incidence of AF in HFpEF patients. Further
studies need to determine whether there is a difference in AF in response to spironolactone
across obese HFpEF pheno groups.

Clinical Trial Registration::
URL: https://clinicaltrials.gov. Unique identifier: NCT00094302. Registered
on October 15, 2004
Correlation Analysis between T790M Status and Clinical Characteristics
of Patients with EGFR-sensitive Mutation Advanced NSCLC who
Progressed after the First Generation and First-line EGFR-TKIs
Administration: A Real-world Exploratory Study
Authors: Zhen Ye , Xu Ying-Bo , Deng Ruo-Ying , Li Meng , Ma Min-Ting , Zhou Zhi-Guo , Meng Qing-Ju , Gong Ya-Ning , Zhao Li-Yan , Liu Yi-Bing 
Published: June 2023

Aims:
The present study is to investigate the association between T790M status and clinical
characteristics of patients with EGFR-sensitive advanced non-small cell lung cancer (NSCLC)
who progressed the initial epidermal growth factor receptor tyrosine kinase inhibitors (EGFRTKIs)
administration.

Methods:
A total of 167 patients with EGFR-sensitive mutations advanced NSCLC who had successful
genetic tests and progressed the initial EGFR-TKI treatment were included in this study retrospectively.
The clinical and demographic characteristics of these patients were collected, which
were manifested as pathological type, metastasis location, initial biopsy method, initial genetic test
specimens, and baseline gene mutations status. Correlation analysis between T790M status and
these characteristics was performed and prognostic analysis regarding the different subgroups was
carried out accordingly.

Results:
The prevalence of secondary T790M after resistance to initial EGFR-TKIs among the 167
patients was 52.7%. Correlation analysis indicated that the median progression-free Survival (PFS)
to initial EGFR-TKIs >12 months were more likely to develop secondary T790M in univariate
analysis. However, the conclusion failed to show statistically significant in multivariate analysis.
Additionally, patients with intracranial progression of initial EGFR-TKIs therapy were associated
with secondary EGFR-T790M. However, it should be noted that those whose best overall response
was partial response (PR) during the EGFR-TKI therapy were relevant to secondary T790M.
Furthermore, The median PFS of the initial EGFR-TKIs administration was longer among patients
with T790M positive mutation and patients with PR reaction than those without T790M mutation
and patients with stable disease (SD), respectively (median PFS: 13.6 vs. 10.9 months, P=0.023)
and (median PFS: 14.0 vs. 10.1 months, P=0.001).

Conclusion:
This retrospective study highlighted the real-world evidence that the best efficacy and
intracranial progression with initial EGFR-TKIs therapy among patients with advanced NSCLC
might be the promising indicators to predict the occurrence of EGFR-T790M. Patients with PR
reaction and T790M positive mutation conferred longer PFS of the initial EGFR-TKIs administration.
Also, the conclusion should be confirmed in more patients with advanced NSCLC subsequently.
Recent Updates on Transdermal Drug Delivery Approaches for the
Management of Gout and its Clinical Perspective
Authors: Harwansh Ranjit K. , Mishra Soumya , Mazumder Rupa , Deshmukh Rohitas , Rahman Akhlaquer 
Published: June 2023

Abstract:
Oral and injectable drug administration have recently been replaced with transdermal
drug delivery (TDD) approaches, which are less intrusive, less likely to be rejected by patients,
and easier to administer. There is still room for improvement in the treatment of gout with the use
of a TDD system. Gout has become a worldwide epidemic and a severe threat to human beings.
Gout treatment can be accomplished in various ways, including orally and intravenously. Several
traditional options are still useless, cumbersome, and potentially dangerous. Hence, gout therapeutic
options are desperately required for more effective and less toxic drug delivery methods. Antigout
medications using TDD could substantially influence obese people in the future, even if most
trials are still in the animal stages. Thus, this review aimed to provide a concise overview of recent
TDD technologies and anti-gout medication delivery methods that improved therapeutic efficacy
and bioavailability. Moreover, clinical updates on investigational drugs have been discussed to
address the potential findings against gout.
Study on the Electrical and Geometrical Parameters of Micro Electrical
Discharge Machining
Authors: Tafraouti Asmae , Layouni Yasmina , Kleimann Pascal 
Published: June 2023

Introduction:
Micro-Electrical Discharge Machining (μEDM) is a technique for noncontact
machining of conductive or semiconductor materials. It is mainly adapted to machining hard
materials. Its principle is based on the creation of electrical discharges between the micro tool and the
workpiece, which are immersed in a dielectric.

Methods:
Methods: It is a complementary process to mechanical or laser micromachining techniques or microelectronics (RIE, DRIE, LIGA). These methods can reach a resolution of 50 nm, but their main drawback is that they are mainly dedicated to silicon. The µEDM process depends on several physical, geometrical, and/or electrical parameters that need to be optimized in order to achieve a resolution lower than 5 µm in a reproducible way. The objective of this paper is to study the effect of the applied voltage VEE and the micro-tool diameter on the machining performances (removed volume, lateral gap, machining depth, and crater shape).

Result:
Result: The optimal parameters were used during drilling holes. An applied voltage of VEE = 50V was used as an optimal parameter.

Conclusion:
Concerning the diameter of the micro tool, we propose to use large diameter wires
(Φ=250μm; Φ=125μm) during the roughing phase for machining complex structures and small diameter
micro tools (Φ=80μm; Φ=40μm; Φ=20μm) during the finishing phase.
Contributing factors in learning programmable logic controller using path analysis
Authors: Zakarijah Masduki , Utomo Pramudi , Rochayati Umi , Mashoedah Mashoedah , Suprapto Suprapto , Sony Arya 
Published: June 2023

Learning Programmable Logic Controller (PLC) programming is influenced by several factors, that is: lecturer competence in PLC programming, adequacy of information technology infrastructure in learning, availability of learning media, vocational guidance procedures, and learning motivation. The purpose of this study: (a) to describe the factors that contribute to PLC programming learning, (b) to formulate a PLC programming competency model, and (c) to examine the determinants of PLC programming learning. Model testing method using Path Analysis. The results of this analysis are expected to be able to describe the relational patterns between variables in learning PLC programming, as well as the direct and indirect impacts on the mastery of PLC programming competencies. Keywords: PLC programming competency, path analysis, vocational education.
Reducing Clinical Trial Monitoring Resources and Costs With Remote Monitoring: Retrospective Study Comparing On-Site Versus Hybrid Monitoring
Authors: Fu Zhiying , Liu Xiaohong , Zhao Shuhua , Yuan Yannan , Jiang Min 
Published: June 2023

Background
Clinical research associates (CRAs) monitor the progress of a trial, verify the data collected, and ensure that the trial is carried out and reported in accordance with the trial protocol, standard operating procedures, and relevant laws and regulations. In response to monitoring challenges during the COVID-19 pandemic, Peking University Cancer Hospital launched a remote monitoring system and established a monitoring model, combining on-site and remote monitoring of clinical trials. Considering the increasing digitization of clinical trials, it is important to determine the optimal monitoring model for the general benefit of centers conducting clinical trials worldwide.

Objective
We sought to summarize our practical experience of a hybrid model of remote and on-site monitoring of clinical trials and provide guidance for clinical trial monitoring management.

Methods
We evaluated 201 trials conducted by our hospital that used on-site monitoring alone or a hybrid monitoring model, of which 91 trials used on-site monitoring alone (arm A) and 110 used a hybrid model of remote and on-site monitoring (arm B). We reviewed trial monitoring reports from June 20, 2021, to June 20, 2022, and used a customized questionnaire to collect and compare the following information: monitoring cost of trials in the 2 models as a sum of the CRAs’ transportation (eg, taxi fare and air fare), accommodation, and meal costs; differences in monitoring frequency; the number of monitored documents; and monitoring duration.

Results
From June 20, 2021, to June 20, 2022, a total of 320 CRAs representing 201 sponsors used the remote monitoring system for source data review and the verification of data from 3299 patients in 320 trials. Arm A trials were monitored 728 times and arm B trials were monitored 849 times. The hybrid model in arm B had 52.9% (449/849) remote visits and 48.1% (409/849) on-site visits. The number of patients’ visits that could be reviewed in the hybrid monitoring model increased by 34% (4.70/13.80; P=.004) compared with that in the traditional model, whereas the duration of monitoring decreased by 13.8% (3.96/28.61; P=.03) and the total cost of monitoring decreased by 46.2% (CNY ¥188.74/408.80; P<.001). These differences were shown by nonparametric testing to be statistically significant (P<.05).

Conclusions
The hybrid monitoring model can ensure timely detection of monitoring issues, improve monitoring efficiency, and reduce the cost of clinical trials and should therefore be applied more broadly in future clinical studies.
Cooking the Course from Scratch
Authors: Petrovic-Dzerdz Maristela , Marini Anthony 
Published: June 2023

Applying course design fundamentals grounded in sound pedagogy is a critical first step when creating outcome-based, student-centred learning experiences. In the described three-hour workshop, the participants worked collaboratively to design a learning activity that included recognition of prerequisite skills and learning outcomes aligned with both instructional strategies and assessment processes. On completion of the activity, each group presented to all participants who, along with facilitators, provided constructive feedback on all components of the designed activity. Workshop satisfaction feedback from seven sessions (four in-class and three online) indicates that the participants were highly satisfied and felt more confident in applying the fundamentals when designing learning activities for their courses.
Keywords: course design, learning experience, teaching, educational development.
AirTouch Communications’ Innovative Disclosure: “Proportionate Financial Data”
Authors: Zeff Stephen A. 
Published: June 2023

ABSTRACT
This note relates and discusses the financial reporting innovation in the 1990s by AirTouch Communications, Inc., a wireless telephone service provider. The innovation was intended to show the parent company’s proportionate ownership share of its subsidiaries’ and joint ventures’ operations, restating key figures from the income statement and operating cash flow. The author corresponded with AirTouch’s then chief financial officer (CFO) for an explanation of the reasoning behind the innovation. Another issue that this note addresses is the opinion given by the audit firm on supplemental disclosures that depart from GAAP.
Fire Resistance of a Building Element with Intumescent Fire Protection: Standard Assessment and Express Analysis
Authors: Martynov A. V. , Grekov V. V. , Popova O. V. 
Published: June 2023

Introduction. The paper considers the problem of fire resistance assessment of building structures with intumescent fire protection. For the results reliability, a fire test should be carried out only when the intumescent coating at the facility is ready, which will make it possible to detect hidden factors of violation of its quality and prevent collapse in case of a possible fire. The work objective is to test the express analysis of intumescent coatings in comparison with standard methods for fire resistance assessment.Materials and Methods. The elements of building structures covered with fire-resistant intumescent paint Defender M Solvent with different diluent content were studied. The fire resistance of the coatings was determined by two methods. The first one is an express analysis. The following indicators were recorded:– general appearance of the coked cellular material (CCM);– swelling coefficient;– CCM compressive and shear-tear strength of the boundary layer.The second one is a standard approach according to the requirements of ISO 834-75 (GOST 30247.0-94). The indicators were:– time to reach the critical temperature;– critical deflection during heating.Results. In addition to the above indicators, testing also took into account the amount of diluent. The CCM swelling coefficient, CCM compression force, tensile strength and density were considered. The revealed patterns are systematized in a table. The obtained indicators were compared with the technical requirements for the material. The period during which the steel substrate of the sample reaches a critical temperature is recorded. It is established that with an increase in this time, the coefficient of swelling of the protective layer (CCM) and its shear-tear strength increases. At the same time, the values of compressive strength and CCM density decrease. When the intumescent paint is diluted beyond the norm, the fire protection parameters deteriorate and the fire resistance limit R45 is not reached. The research results are visualized in the form of diagrams. They confirm that the express analysis makes it possible to reasonably judge the suitability or unsuitability of the paint for fire protection, if the required fire resistance limit is R45.Discussion and Conclusions. In comparison with the results of the application of standard techniques, the effectiveness of the express analysis technique and the correctness of the results of the assessment of intumescent fire protection were confirmed. In construction conditions, an express CCM analysis will be sufficient to determine the quality of an intumescent fire retardant coating.
On the Issue of Assessing the Levels of Noise and Vibration Impacts on Workers of Industrial Enterprises of the Republic of Kazakhstan
Authors: Shirvanov R. B. , Zhumagaliyev I. K. 
Published: June 2023

Introduction. Ensuring safe and comfortable working conditions is one of the most important tasks in the organization of modern production processes that have a direct impact on employee productivity, injuries and occupational diseases. Despite all the efforts made both at the state and departmental levels, the current state of occupational safety and health of industrial workers in the Republic of Kazakhstan continues to remain at an insufficiently high level. The main cause of occupational injuries and occupational diseases is the impact on working personnel of dangerous and harmful production factors, one of which is an increased level of noise and vibration from production equipment. The authors analyze statistical data on the number of cases of injuries, their types and causes of occurrence in workers by sectors of the economy of the republic. The influence of noise and vibration on the health of workers is considered. It is found that an increased level of noise and vibration effects causes injuries to a lesser extent, and occupational diseases to a greater extent. The work objective is instrumental measurement of noise and vibration levels in the workplaces of production sites of a machine-building enterprise and assessment of working conditions there to develop effective measures to reduce the harmful effects on the health of workers.Materials and Methods. Statistical data on occupational injuries and occupational diseases were used as basic information, as well as the results of instrumental measurements of the level of noise and vibration effects on workers using the methods set out in GOST ISO 9612-2016 and GOST 31319-2006, taking into account Order of the Minister of Health of the Republic of Kazakhstan of February 16, 2022 № KR DSM-15 «On approval of hygienic standards to physical factors that have an impact on a person».Results. The results of the conducted research allowed us to conclude that about 22.6% of workplaces at production sites are characterized by harmful and dangerous working conditions in terms of noise and vibration effects on workers.Discussion and Conclusion. Based on the results of the study, a plan of priority measures was developed to reduce the harmful effects of increased noise and vibration in the workplace. The authors also recommend a special working regime, benefits and additional payments to employees for working conditions that do not meet safety requirements.
Assessment of the Impact of Oil Production Processes on the Health of the Population of Oil-Producing Areas of the Irkutsk Region
Authors: Khamidullina E. A. , Vasileva V. V. 
Published: June 2023

Introduction. The state of the population health depends on the ecological and hygienic well-being of the territory. In places with developed oil production, there is a long-term impact of pollutants on the human body and, as a result, corresponding diseases develop. This is evidenced by numerous domestic and foreign studies, but the territory of the Irkutsk region is not covered by such studies. Therefore, the work objective is to assess the impact of oil production processes on the incidence of the population of oil-producing regions of the Irkutsk region.Materials and Methods. The source materials were the statistical indicators of overall and primary disease incidence of the population of the regions of the Irkutsk region for the period from 2016 to 2019, posted on the website of medical statistics of the Irkutsk region. For the calculation of the non-carcinogenic risk, we have used environmental monitoring data from an oil-producing company based on average daily concentrations of pollutants in oil-producing areas.Results. It is shown that oil-producing areas are characterized by extremely high incidence rates for such groups of diseases as respiratory diseases, diseases of the circulatory system, diseases of the musculoskeletal system, diseases of the digestive system, diseases of the genitourinary system, as well as deviations in pregnancy, childbirth and the postpartum period. Infant mortality rates in these territories are up to 4 times higher than the corresponding average indicators for the Irkutsk region as a whole. The calculation of non-carcinogenic risk showed an excess over the permissible values accepted in Russia.Discussion and Conclusions. The results of the analysis testify to the unfavorable medical and demographic situation in the territories under discussion. The pronounced excess of the incidence rate for the presented groups of diseases in the oilfield areas in comparison with the territories taken for comparison reflects the possible impact of environmental pollution on the health of the population. A connection between the growth of infant mortality in the territories under consideration and the beginning of the industrial development of hydrocarbon deposits in these places has been revealed. The contribution of oil companies to the socio-economic development of the regions, including co-financing of medical care for the population, could partially offset the negative impact of industrial processes.