bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying a theory of change approach to develop and pilot a universal mental health literacy curriculum for adolescents
Authors: Kagstrom Anna , Juríková Laura , Pešout Ondřej , Šimsa Benjamin , Winkler Petr 
Published: May 2023

AbstractUniversal evidence‐based prevention and promotion programs lack in availability and scalability for child and adolescent mental health in Central and Eastern Europe. This paper describes the process of applying the theory of change to plan, develop, and pilot a mental health literacy intervention in Czech schools. The process of using theory of change to develop a complex intervention for mental health literacy is described across three stages: formative development, piloting, and evaluation. The application of evidence‐based intervention was discussed within 64 diverse stakeholder meetings and tested over 2 years of piloting. The resulting theory of change map is described in the context of consideration for modifications, revisions, and recommendations for successful implementation of the developed intervention. Continued monitoring and evaluation and a formal evaluation of the effectiveness of mental health literacy curriculum within the region will be essential before scale‐up.
A porcine bladder model of pre‐clinical urodynamics demonstrates increased afferent nerve activity during filling
Authors: Moore R. Hart , Ghatas Mina P. , Rogers Devin , Bednarz Christopher , Shields Michael , Grob Gabrielle , Burkett Linda S. , Muthusamy Selvaraj , Speich John E. , Klausner Adam P. 
Published: May 2023

AbstractIntroduction and ObjectivesUrodynamics are the accepted gold standard for the evaluation of multiple forms of voiding dysfunction. However, the tests are expensive, invasive, poorly reproducible, and often prone to artifacts. Therefore, there is a pressing need to develop next‐generation urodynamics. The purpose of this study was to develop a novel ex vivo porcine bladder urodynamics model with afferent pelvic nerve signaling that can be used as a preclinical surrogate for bladder sensation.MethodsPorcine bladders including the ureters and vascular supply were harvested from local abattoirs using an established protocol in both male and female animals. Ex vivo bladder perfusion was performed using physiologic MOPS (3‐(N‐morpholino) propanesulfonic acid) buffer solution. The pelvic nerve adjacent to the bladder was grasped with micro‐hook electrodes and electroneurogram (ENG) signals recorded at 20 kHz. Bladders were filled with saline at a nonphysiologic rate (100 mL/min) to a volume of 1 L using standard urodynamics equipment to simultaneously record intravesical pressure. ENG amplitude was calculated as the area under the curve for each minute, and ENG firing rate was calculated as number of spikes (above baseline threshold) per minute. At the conclusion of the experiment, representative nerve samples were removed and processed for nerve histology by a pathologist (hematoxylin and eosin and S100 stains).ResultsA total of 10 pig bladders were used, and nerve histology confirmed the presence of nerve in all adequately processed samples. Vesical pressure, ENG firing rate, and ENG amplitude all increased as a function of filling. During filling tertiles (low fill: min 1–3, med fill: min 4–6, and high fill: min 7–10), normalized pressures were 0.22 ± 0.04, 0.38 ± 0.05, and 0.72 ± 0.07 (cmH2O). Similarly, normalized ENG firing rates were 0.08 ± 0.03, 0.31 ± 0.06, and 0.43 ± 0.04 spikes/minute, respectively, and normalized nerve amplitudes were 0.11 ± 0.06, 0.39 ± 0.06, and 0.56 ± 0.14) μV, respectively. Strong relationships between average normalized pressure values and averaged normalized ENG firing rate (r2 = 0.66) and average normalized ENG amplitude (r2 = 0.8) were identified.ConclusionsThe ex vivo perfused porcine bladder can be used as a preclinical model for the development of next‐generation urodynamics technologies. Importantly, the model includes a reproducible method to measure afferent nerve activity that directly correlates with intravesical pressure during filling and could potentially be used as a surrogate measure of bladder sensation.
In situ reinforced poly(ether ether ketone) nanocomposites by covalently modified multiwalled carbon nanotubes via surface‐grafting polymerization
Authors: Jiang Zilong , Chen Tianwu , Wang Zhaoyang , Han Jinxuan , Zhang Chunling , Jiang Bo , Shang Yingshuang , Zhang Haibo 
Published: May 2023

AbstractCovalent modification of multiwalled carbon nanotubes (MWCNTs) is an efficient way to improve the interfacial interaction and compatibility between MWCNTs and the matrix. In this article, MWNCTs were covalently modified by 4,4′‐difluorobenzophenone (DB) to allow temperature‐tolerant functional groups on the walls. These surface‐functionalized MWCNTs (MWCNTs‐DB) were then attached to poly(ether ether ketone) (PEEK) resins by in situ grafting polymerization, to prepare high‐strength PEEK nanocomposites. The addition of 1 wt% MWCNTs‐DB improved the tensile and flexural strength of the PEEK nanocomposite by 28% and 22%, respectively, compared with pristine PEEK. In particular, the optimal break at strain of the PEEK nanocomposites reaches 39%. The glass transition temperature of the PEEK nanocomposites increased from 148 to 153°C, indicating strong interfacial interactions between MWNCTs and PEEK. Furthermore, scanning electron microscopy images confirmed the amelioration of MWNCTs dispersion in PEEK resins achieved by in situ grafting polymerization. Our results demonstrate the potential of surface‐functionalized carbon nanotubes for use in high‐temperature applications and offer innovative protocols for designing and preparing high‐performance nanocomposites with enhanced mechanical properties, which could have applications in various fields such as aerospace, automotive, and biomedical engineering.
Abnormalities of the corpus callosum. Can prenatal imaging predict the genetic status? Correlations between imaging phenotype and genotype
Authors: Nguyen Toan , Heide Solveig , Guilbaud Lucie , Valence Stéphanie , Perre Saskia Vande , Blondiaux Eléonore , Keren Boris , Quenum‐Miraillet Geneviève , Jouannic Jean‐Marie , Mandelbrot Laurent , Picone Olivier , Guet Agnès , Tsatsaris Vassilis , Milh Mathieu , Girard Nadine , Vincent Marie , Nizon Mathilde , Poirsier Céline , Vivanti Alexandre , Benachi Alexandra , Portes Vincent des , Guibaud Laurent , Patat Olivier , Spentchian Myrtille , Frugère Lisa , Héron Delphine , Garel Catherine 
Published: May 2023

AbstractObjectiveRecent studies have evaluated prenatal exome sequencing (pES) for abnormalities of the corpus callosum (CC). The objective of this study was to compare imaging phenotype and genotype findings.MethodThis multicenter retrospective study included fetuses with abnormalities of the CC between 2018 and 2020 by ultrasound and/or MRI and for which pES was performed. Abnormalities of the CC were classified as complete (cACC) or partial (pACC) agenesis of the CC, short CC (sCC), callosal dysgenesis (CD), interhemispheric cyst (IHC), or pericallosal lipoma (PL), isolated or not. Only pathogenic (class 5) or likely pathogenic (class 4) (P/LP) variants were considered.Results113 fetuses were included. pES identified P/LP variants for 3/29 isolated cACC, 3/19 isolated pACC, 0/10 isolated sCC, 5/10 isolated CD, 5/13 non‐isolated cACC, 3/6 non‐isolated pACC, 8/11 non‐isolated CD and 0/12 isolated IHC and PL. Associated cerebellar abnormalities were significantly associated with P/LP variants (OR = 7.312, p = 0.027). No correlation was found between phenotype and genotype, except for fetuses with a tubulinopathy and an MTOR pathogenic variant.ConclusionsP/LP variants were more frequent in CD and in non‐isolated abnormalities of the CC. No such variants were detected for fetuses with isolated sCC, IHC and PL.
The role of colorblind racism and white fragility in maintaining racist bullying in middle school
Authors: Jones Tiffany M. , Williford Anne , Malorni Angela , McCowan Kristin , Becker Kaylee , Halac Tess , Lea Charles H. , Spencer Michael S. 
Published: May 2023

AbstractThe present study sought to understand how colorblind racism (CBR) and white fragility (WF) influence the presence and perpetration of racist bullying in a middle school setting. Five focus groups and one interview (n = 20) were conducted with school administrators, teachers, and racially and ethnically diverse students to elicit their experiences and perspectives concerning racist bullying. Focus groups were analyzed using template analysis. Racist bullying was a common experience among racial and ethnic minoritized students. CBR and WF were evident as white students and teachers claimed students had similar experiences regardless of race, they minimized the impact of racist bullying, and silenced discussions of race and racism. CBR and WF were critical drivers of the maintenance of racist bullying in this middle school, and thus important to address in efforts to prevent racist bullying.
Meaning‐centered pain coping skills training for patients with metastatic cancer: Results of a randomized controlled pilot trial
Authors: Winger Joseph G. , Kelleher Sarah A. , Ramos Katherine , Check Devon K. , Yu Justin A. , Powell Victoria D. , Lerebours Reginald , Olsen Maren K. , Keefe Francis J. , Steinhauser Karen E. , Porter Laura S. , Breitbart William S. , Somers Tamara J. 
Published: May 2023

AbstractObjectiveFor patients with advanced cancer, pain is a common and debilitating symptom that can negatively impact physical, emotional, and spiritual well‐being. This trial examined the feasibility and initial effects of Meaning‐Centered Pain Coping Skills Training (MCPC), a cognitive‐behavioral pain management intervention with an emphasis on enhancing meaning (i.e., a personal sense of purpose, worth, and significance) and peace.MethodsWe enrolled 60 adults with stage IV solid tumor cancers and moderate‐severe pain between February 2021 and February 2022. Participants were randomized 1:1 to MCPC + usual care or usual care alone. Meaning‐Centered Pain Coping Skills Training consisted of four weekly 60‐min individual sessions via videoconference or telephone, delivered by a trained therapist using a manualized protocol. Participants completed validated measures of pain severity, pain interference, pain self‐efficacy, spiritual well‐being (i.e., meaning, peace, and faith), and psychological distress at baseline and 5‐week and 10‐week follow‐ups.ResultsAll feasibility metrics exceeded prespecified benchmarks. Fifty‐eight percent of screened patients were eligible, and 69% of eligible patients consented. Of those assigned to MCPC, 93% completed all sessions and 100% of those who completed follow‐ups reported using coping skills weekly. Retention was strong at 5‐week (85%) and 10‐week (78%) follow‐ups. Meaning‐Centered Pain Coping Skills Training participants reported better scores than control participants across outcome measures, including moderate‐to‐large sized differences at 10‐week follow‐up in pain severity (Cohen's d = −0.75 [95% confidence interval: −1.36, −0.14]), pain interference (d = −0.82 [‐1.45, −0.20]), and pain self‐efficacy (d = 0.74 [0.13, 1.35]).ConclusionsMCPC is a highly feasible, engaging, and promising approach for improving pain management in advanced cancer. Future efficacy testing is warranted.Trial registrationClinicalTrials.gov Identifier: NCT04431830, registered 16 June 2020.
The paediatric physiotherapy curricula landscape: A survey of United Kingdom entry‐level programs
Authors: Chesterton Paul , Chesterton Jennifer 
Published: May 2023

AbstractBackground and PurposeTo identify the paediatric curriculum content covered in entry‐level physiotherapy programs within the United Kingdom (UK), and report faculties perceived importance. Strengths, weaknesses, barriers and facilitators, to the implementation of paediatric content were explored.MethodsA cross‐sectional online questionnaire captured entry‐level physiotherapy programme leaders' perceptions of paediatric programs.ResultsFifty‐five responses were submitted, providing a 67% completion rate. Faculty perceived that students' felt the inclusion of paediatric content within the curricula was ‘Important’ (Mean 3.60 ± SD 0.74). Of 30 diagnoses surveyed, only two were covered ‘Well’ within curriculums, despite 23 rated at least ‘Important’ by respondents. Of the 18 assessment/examination components, 13 were covered ‘Well’ with five ‘Somewhat’. All were considered to be at least ‘Important’. Perceived strengths were grouped into three main categories (1) integrated/lifespan approach, (2) links to clinical specialists, and (3) a broad/detailed curriculum. Perceived weaknesses included curriculum time pressures and paediatric placement availability.DiscussionThe majority of paediatric conditions were only somewhat covered by UK curriculums, despite respondents in the main believing they should be an important element of the entry‐level syllabus. Some UK physiotherapy entry‐level students may not be exposed to any paediatric teaching or clinical placements.
Upgrading on Per Protocol versus For Cause surveillance prostate biopsies: An opportunity to decreasing the burden of active surveillance
Authors: Wang Michael , Lange Andrew , Perlman David , Qi Ji , George Arvin K. , Ferrante Stephanie , Semerjian Alice , Sarle Richard , Cher Michael L. , Ginsburg Kevin B. ,   for the Michigan Urological Surgery Improvement Collaborative
Published: May 2023

AbstractBackgroundMost prostate cancer (PC) active surveillance (AS) protocols recommend “Per Protocol” surveillance biopsy (PPSBx) every 1–3 years, even if clinical and imaging parameters remained stable. Herein, we compared the incidence of upgrading on biopsies that met criteria for “For Cause” surveillance biopsy (FCSBx) versus PPSBx.MethodsWe retrospectively reviewed men with GG1 PC on AS in the Michigan Urological Surgery Improvement Collaborative (MUSIC) registry. Surveillance prostate biopsies obtained 1 year after diagnosis were classified as either PPSBx or FCSBx. Biopsies were retrospectively deemed FCSBx if any of these criteria were met: PSA velocity > 0.75 ng/mL/year; rise in PSA > 3 ng from baseline; surveillance magnetic resonance imaging (MRI) (sMRI) with a PIRADS ≥ 4; change in DRE. Biopsies were classified PPSBx if none of these criteria were met. The primary outcome was upgrading to ≥GG2 or ≥GG3 on surveillance biopsy. The secondary objective was to assess for the association of reassuring (PIRADS ≤ 3) confirmatory or surveillance MRI findings and upgrading for patients undergoing PPSBx. Proportions were compared with the chi‐squared test.ResultsWe identified 1773 men with GG1 PC in MUSIC who underwent a surveillance biopsy. Men meeting criteria for FCSBx had more upgrading to ≥GG2 (45%) and ≥GG3 (12%) compared with those meeting criteria for PPSBx (26% and 4.9%, respectively, p < 0.001 and p < 0.001). Men with a reassuring confirmatory or surveillance MRI undergoing PPSBx had less upgrading to ≥GG2 (17% and 17%, respectively) and ≥GG3 (2.9% and 1.8%, respectively) disease compared with men without an MRI (31% and 7.4%, respectively).ConclusionsPatients undergoing PPSBx had significantly less upgrading compared with men undergoing FCSBx. Confirmatory and surveillance MRI seem to be valuable tools to stratify the intensity of surveillance biopsies for men on AS. These data may help inform the development of a risk‐stratified, data driven AS protocol.
Treatment outcomes of simultaneous integrated boost to intraprostatic lesions with external beam radiotherapy in localized prostate cancer patients
Authors: Onal Cem , Erbay Gurcan , Guler Ozan C. , Yavas Cagdas , Oymak Ezgi 
Published: May 2023

AbstractBackgroundTo evaluate the treatment outcomes and toxicity of definitive radiotherapy (RT) for prostate cancer (PC) patients using the simultaneous integrated boost (SIB) technique, which delivered 78 Gy to the entire prostate and 86 Gy to the intraprostatic lesion (IPL) in 39 fractions.Materials and MethodsUnivariable and multivariable analyses were conducted of the prognostic factors for freedom from biochemical failure (FFBF), progression‐free survival (PFS), and PC‐specific survival (PCSS) of 619 PC patients who received definitive RT between September 2012 and August 2021. Predictors of late Grade ≥2 genitourinary (GU) and gastrointestinal (GI) toxicities were also identified using logistic regression.ResultsThe median follow‐up for entire cohort was 68.5 months. The 5‐year FFBF, PFS, and PCSS rates were 93.2%, 83.2%, and 98.6%, respectively. They were predicted by the serum prostate‐specific antigen, Gleason score (GS), clinical nodal stage, and D'Amico risk group. Only 45 patients (7.3%) developed disease recurrence 41.9 months after RT. The 5‐year FFBF rates for low‐, intermediate‐, and high‐risk disease were 98.0%, 93.1%, and 88.5%, respectively (p < 0.001). The 5‐year PFS and PCSS rates according to risk groups were 91.0%, 82.1%, and 77.4% (p < 0.001), and 99.2%, 96.4%, and 95.9% (p = 0.03), and, respectively. GS > 7 and lymph node metastasis negatively predicted FFBF and PCSS in multivariable analysis. Ninety (14.6%) and 44 (7.1%) patients had acute Grade ≥2 GU and GI toxicities, respectively, and 42 (6.8%) and 27 (4.4%) patients had late Grade ≥2 GU and GI toxicities, respectively. Diabetes and transurethral resection independently predicted late Grade 2 GU toxicity, but no significant predictor of late Grade ≥2 GI toxicity was found.ConclusionsLocalized PC was effectively and safely treated with definitive RT using the SIB technique to deliver 86 Gy to the IPL in 39 fractions without severe late toxicity. This finding must be validated with long‐term results.
Comparative demographics, population projections and egg maturation patterns of four eupelmid egg parasitoids on the factitious host Antherae pernyi
Authors: Mu Ming‐Yue , Chen Yong‐Ming , Wang Xingeng , Desneux Nicolas , Zang Lian‐Sheng 
Published: May 2023

AbstractBACKGROUNDThe genera Anastatus and Mesocomys (both Hymenoptera: Eupelmidae) are important solitary egg endoparasitoids as biological control agents for lepidopterous and hemipterous pests worldwide. Here, we comparatively evaluated the demographic parameters of four important eupelmid egg parasitoids (Anastatus fulloi, A. japonicus, Mesocomys albitarsis and M. trabalae) reared on the factitious host eggs of the Chinese oak silkworm Antheraea pernyi, using age‐stage two‐sex life tables, their population projections as well as egg maturation patterns.RESULTSBoth the age‐specific net reproductive rate (lxmx) and reproductive value (vxj) increased initially and then gradually decreased with increasing age in all four parasitoid species. Overall, the two Mesocomys species had higher survival rates at stable age‐stage distribution, peak reproductive values, and intrinsic rates of increase than the two Anastatus species. Mesocomys albitarsis had the longest longevity, whereas A. japonicus had the longest oviposition days and mean generation time. The two Mesocomys species are thus projected to have faster population increase than the two Anastatus species. Adult females of all four parasitoid species emerged with only a few mature eggs (< 6 eggs) and most of their eggs were matured post‐emergence (strict synovigeny). The estimated 90% of lifetime complement of reproduction (offspring) and realized days were 374 and 32 for A. japonicus, 337 and 22 for M. trabalae, 330 and 19 for M. albitarsis and 147 and 28 for A. fulloi.CONCLUSIONOur results indicated that the two Mesocomys species have higher control capacity than the two Anastatus species. Provision of adult food for these strictly synovigenic parasitoids would be essential to prolong their lifespan and continuously produce eggs for parasitizing their hosts for mass rearing or augmentative biological control programs. © 2023 Society of Chemical Industry.
Distribution of the follicular and luteal phase lengths and their age‐dependent changes in Japanese women: A large population study
Authors: Mitake Sawa , Wada‐Hiraike Osamu , Kashiwabara Kosuke , Nakamura Akari , Nasu Risa , Hine Maaya , Matsuyama Yutaka , Fujii Tomoyuki , Osuga Yutaka 
Published: May 2023

AbstractPurposeThe current definition of menstrual cycle length in a Japanese woman is different from those of WHO definition, and the original data are outdated. We aimed to calculate the distribution of follicular and luteal phases length in modern Japanese women with various menstrual cycles.MethodsThis study determined the lengths of the follicular and luteal phases of Japanese women using basal body temperature data collected via a smartphone application from 2015 to 2019, and the data were analyzed using the Sensiplan method. Over 9 million temperature readings from more than 80 000 participants were analyzed.ResultsThe mean duration of the low‐temperature (follicular) phase averaged 17.1 days and was shorter among participants aged 40–49 years. The mean duration of the high‐temperature (luteal) phase was 11.8 days. The variance and maximum‐minimum difference of the length of the low temperature period were significant in women under 35 years old than women aged more than 35 years.ConclusionsThe shortening of the follicular phase in women aged 40–49 years implied a relationship with the rapid decline of ovarian reserve in these women, and the age 35 years old was turning point of ovulatory function.
Active disturbance rejection‐based event‐triggered bipartite consensus control for nonaffine nonlinear multiagent systems
Authors: Cao Zhongwen , Niu Ben , Zong Guangdeng , Zhao Xudong , Ahmad Adil M. 
Published: May 2023

AbstractThis article investigates the active disturbance rejection‐based distributed event‐triggered bipartite consensus problem of nonaffine nonlinear multiagent systems with input saturation. To reduce the update frequency of the control signal, an event‐triggered mechanism is employed for each follower. Additionally, the active disturbance rejection technology, as a combination of the extended state observer and the tracking differentiator, is introduced to estimate the uncertainties of the system and address the problem of explosion of complexity in the backstepping design process. Compared with the traditional distributed bipartite consensus schemes using neural networks/fuzzy logic systems, the design complexity of the control law is reduced in the proposed scheme. Meanwhile, the tracking error is maintained within a predefined range via the funnel function. Finally, the stability of the system is proved under the Lyapunov stability analysis theory, and the effectiveness of the proposed strategy is verified via simulation examples.