bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forever Girls
Authors: Choi Jinhee 
Published: January 2025

Abstract
Forever Girls explores the girlhood and the image of death manifest in contemporary South Korean cinema. In both classical and contemporary South Korean cinema, girls’ bodies have repeatedly embodied various conflicting socio-political forces that shaped the nation: coloniality, post-colonial and post-war traumas, modernity, and democracy. The book reorients the direction of current scholarship on contemporary Korean cinema from patriarchy, masculinity, and violence, to consider girls as a social imaginary. Drawing on the depiction of girlhood from the 1970s as a reference image, including that of low-wage working-class girls, it explores the extent to which the girlhood represented in the millennial South Korean cinema still resonates with such an image. Girls have begun to earn limited agency as subjects who remember the past, experience the present, and envision the future; their interiority lies beyond their status as victims of sexual violence and national trauma. From the popular teen pictures and male auteurs’ work of the 1970s, to a contemporary film cycle on military sexual slavery (“wianbu”), to Bong Joon-ho’s girl trilogy and to Korean independent cinema of the 2010s, directed by women directors, Forever Girls focuses on girls’ sexuality, labor, and leisure, and critically engages with the girlhood associated with unproductivity and dismissed as mere irreality. It foregrounds the ways in which cinema could adequately mourn girls’ deaths or grant them shelter and idleness that they desperately need: the very girlhood that has long been denied due to girls’ familial and gender roles.
Polygenic prediction for underrepresented populations through transfer learning by utilizing genetic similarity shared with European populations
Authors: Zhu Yiyang , Chen Wenying , Zhu Kexuan , Liu Yuxin , Huang Shuiping , Zeng Ping 
Published: January 2025

Abstract
Because current genome-wide association studies are primarily conducted in individuals of European ancestry and information disparities exist among different populations, the polygenic score derived from Europeans thus exhibits poor transferability. Borrowing the idea of transfer learning, which enables the utilization of knowledge acquired from auxiliary samples to enhance learning capability in target samples, we propose transPGS, a novel polygenic score method, for genetic prediction in underrepresented populations by leveraging genetic similarity shared between the European and non-European populations while explaining the trans-ethnic difference in linkage disequilibrium (LD) and effect sizes. We demonstrate the usefulness and robustness of transPGS in elevated prediction accuracy via individual-level and summary-level simulations and apply it to seven continuous phenotypes and three diseases in the African, Chinese, and East Asian populations of the UK Biobank and Genetic Epidemiology Research Study on Adult Health and Aging cohorts. We further reveal that distinct LD and minor allele frequency patterns across ancestral groups are responsible for the dissatisfactory portability of PGS.
Linezolid Dosing and Pharmacokinetics in North American Patients With Tuberculosis
Authors: Maranchick Nicole F , Peloquin Charles A , Haley Connie A 
Published: January 2025

Abstract

Background
Linezolid is recommended in treatment regimens for rifampin- or multidrug-resistant tuberculosis (TB). However, considerable pharmacokinetic variability exists, and long-term use is limited by adverse effects. This study evaluates the pharmacokinetics of linezolid in patients with TB from an international therapeutic drug monitoring (TDM) service.

Methods
Linezolid trough, 2-hour, and 6-hour postdose clinical samples from across North America were tested by the University of Florida Infectious Disease Pharmacokinetics Laboratory. Total serum concentrations were measured using liquid chromatography–tandem mass spectrometry. TDM was performed, and measurements were compared to typical linezolid concentrations including a trough value of &lt;2 μg/mL and peak value between 12 and 26 μg/mL.

Results
From January 2019 to December 2023, 1604 linezolid samples from 500 patients and 817 unique TDM occasions were analyzed. Trough concentrations were measured on 670 samples (median, 1.19 [range, 0.00–20.06] μg/mL), and 232 troughs (34.6%) were &gt;2 μg/mL. Among trough samples from linezolid dosing of 600 mg daily, 43.2% were &gt;2 μg/mL. Of 600 peak samples, 264 (44%) were outside the typical range, most (89%) being subtherapeutic at &lt;12 μg/mL.

Conclusions
High serum linezolid trough concentrations were measured in approximately one-third of samples and in &gt;40% of those taking the recommended dose. More than 40% of peak concentrations were outside typical range, of which 89% were &lt;12 μg/mL. This study demonstrates that TDM can be used to identify patients with serum linezolid concentrations outside of targeted ranges, allowing clinicians to make appropriate dose adjustments to improve outcomes.
Destructive Behaviour, Judgement, and Economic Decision-making under Thermal Stress
Authors: Almås Ingvild , Auffhammer Maximilian , Bold Tessa , Bolliger Ian , Dembo Aluma , Hsiang Solomon M , Kitamura Shuhei , Miguel Edward , Pickmans Robert 
Published: January 2025

Abstract
Accumulating evidence indicates that environmental temperature substantially affects economic outcomes and violence, but the reasons for this linkage are only partially understood. We study whether temperature directly influences behaviour by evaluating the effect of thermal stress on multiple dimensions of economic decision-making, judgement, and destructive behaviour with 2,000 participants in Kenya and the US who were randomly assigned to different temperatures in a laboratory. The main finding is that most major dimensions of economic decision-making are unaffected by temperature. We also find that heat significantly increases willingness to voluntarily destroy other participants’ assets in the Kenyan sample.
Clinical risk factors caused by third molar levelling following extraction of a mandibular second molar
Authors: Kato Chiho , Ishizuka Keita , Ono Takashi 
Published: January 2025

Abstract

Background/Objectives
Mandibular second molar (MdM2) is often lost, and its space is filled with a bridge or implant. MdM2 extraction followed by orthodontic treatment protracting mandibular third molar (MdM3) towards the MdM2 position may overcome the missing of MdM2. The objectives of our study were to describe the outcome of the procedure and examined clinical risk factors such as external apical root resorption (EARR) and alveolar bone loss (ABL), as the indicators of poor orthodontic treatment outcomes.

Materials/Methods
This retrospective study included 70 cases in 56 patients who received orthodontic treatment at Tokyo Medical and Dental University Hospital between 2007 and 2018. Multi-bracket appliances were used in all patients for MdM3 protraction. Using linear mixed effects models, EARR and ABL were regressed on various factors, including panoramic and cephalometric variables.

Results
With the mean treatment duration of 1040.4 ± 441.8 days, MdM2 space closure was achieved in 92.8% (65 cases). The ANB angle (P = .023) and the use of temporary anchorage devices (TADs) (P = .021) were significantly associated with the greater EARR, while the mandibular plane angle (P = .033) was associated with the greater ABL. MdM3 protraction using the fixed appliances resulted in the closure of MdM2 space in &gt; 90% of cases without evident root resorption.

Limitation
There is a possibility of residual confounding due to the nature of observational study.

Conclusion/Implication
Orthodontic treatment of MdM3 protraction may be a feasible strategy to close the space of the missing MdM2.
Scpep1 inhibition attenuates myocardial infarction-induced dysfunction by improving mitochondrial bioenergetics
Authors: Chen Guilin , Gan Jing , Wu Fan , Zhou Zengxian , Duan Zikun , Zhang Ke , Wang Songxue , Jin Hua , Li Yulin , Zhang Chi , Lin Zhuofeng 
Published: January 2025

Abstract

Background and Aims
Myocardial infarction (MI) is an ischaemic cardiovascular disease associated with increased morbidity and mortality. Previous studies have suggested that serine carboxypeptidase 1 (Scpep1) is involved in vascular diseases; however, its role in cardiac diseases remains unclear. This study aims to explore the role of Scpep1 in regulating cardiac homeostasis during MI.

Methods
The impact of Scpep1 deficiency or cardiac-specific knock-down and Scpep1 overexpression on heart function was evaluated in mice with MI. Its downstream functional mediators of Scpep1 were elucidated using proteomic analysis and confirmed by employing loss- and gain-of-function strategies.

Results
Circulating and cardiac Scpep1 levels were up-regulated in mice with MI. Genetic ablation or cardiac-specific knock-down of Scpep1 alleviated MI-induced cardiac dysfunction and damage in mice. In contrast, cardiac-specific Scpep1 overexpression aggravated these adverse effects. Mechanistically, Scpep1 exacerbated MI-induced cardiac dysfunction and damage by impaired mitochondrial bioenergetics via binding to Pex3 to promote its degradation, ultimately contributing to mitochondrial fission and apoptosis. Moreover, the expressional profiles of Scpep1 in plasma samples and heart tissues of patients with MI or ischaemic cardiomyopathy were in line with those observed in the mouse models. In addition, pharmaceutical inhibition of Scpep1 notably improved MI-induced cardiac dysfunction and damage by improving mitochondrial fragmentation and bioenergetics post-MI.

Conclusions
Scpep1 deficiency mitigates MI by improving Pex3-mediated mitochondrial fission and subsequent cardiomyocyte apoptosis. Scpep1 constitutes a potential therapeutic target for attenuating MI.
RcSRR1 interferes with the RcCSN5B-mediated deneddylation of RcCRL4 to modulate RcCO proteolysis and prevent rose flowering under red light
Authors: Wang Weinan , Sun Jingjing , Fan Chunguo , Yuan Guozhen , Zhou Rui , Lu Jun , Liu Jinyi , Wang Changquan 
Published: January 2025

Abstract
Light is essential for rose (Rosa spp.) growth and development. Different light qualities play differing roles in the rose floral transition, but the molecular mechanisms underlying their effects are not fully understood. Here we observed that red light suppresses rose flowering and increases the expression of Sensitivity to Red Light Reduced 1 (RcSRR1) compared with white light. Virus-induced gene silencing (VIGS) of RcSRR1 led to early flowering under white light and especially under red light, suggesting that this gene is a flowering repressor with a predominant function under red light. We determined that RcSRR1 interacts with the COP9 Signalosome Subunit 5B (RcCSN5B), while RcCSN5B, RcCOP1 and RcCO physically interact with each other. Furthermore, the RcCSN5B-induced deneddylation of Cullin4-RING E3 Ubiquitin Ligase (RcCRL4) in rose was reduced by the addition of RcSRR1, suggesting that the interaction between RcSRR1 and RcCSN5B relieves the deneddylation of the RcCRL4-COP1/SPA complex to enhance RcCO proteolysis, which subsequently suppresses the transcriptional activation of RcFT and ultimately flowering. Far-red Light Related Sequence Like 1 (RcFRSL3) was shown to specifically bind to the G-box motif of the RcSRR1 promoter to repress its transcription, removing its inhibition of RcFT expression and inducing flowering. Red light inhibited RcFRSL3 expression, thereby promoting the expression of RcSRR1 to inhibit flowering. Taken together, these results provide a previously uncharacterized mechanism by which the RcFRSL3–RcSRR1–RcCSN5B module targets RcCO stability to regulate flowering under different light conditions in rose plants.
The optimal ordering and packaging policies in e-commerce environment
Authors: Lin Tien-Yu , Ye Ning , Dai Shu-Long 
Published: January 2025

Abstract
Accepted by: M. Zied BABAI
Refunds pose a considerable challenge for e-tailers in China, and the primary cause of customer returns often stems from damage to goods attributed to improper logistics and shipping. However, employing appropriate packaging materials or techniques can significantly diminish the refund rate associated with commodity collision or crush. This paper concentrates on optimal ordering and packaging policies, wherein retailers allocate additional costs to enhance packaging techniques or materials, aiming to curtail the rate of damage to goods in transit. The theoretical findings indicate that retailers investing in new packaging materials or technologies can substantially impact the order quantity compared to scenarios where no such investments are made. An algorithm has been devised to investigate optimal ordering and packaging policies, with numerical examples illustrating the proposed model and algorithm. Through a sensitivity analysis, the paper explores the influence of four critical parameters—demand rate, setup cost, refund rate, and holding cost—on the optimal strategy. The discussion also provides managerial insights into the implications of the study.
Analytical Validation and Performance of a Blood-Based P-tau217 Diagnostic Test for Alzheimer Disease
Authors: Abel Adam , Chambers Antonio , Fill Jeff , Reiske Heinz , Lu Ming , Morris Amanda , Faya Paul , Beck Rose C , Pontecorvo Michael J , Collins Emily C , Schade Andrew E , Mintun Mark A , Hodsdon Michael E 
Published: January 2025

Abstract

Background
Blood-based biomarkers, especially P-tau217, have been gaining interest as diagnostic tools to measure Alzheimer disease (AD) pathology.

Methods
We developed a plasma P-tau217 chemiluminescent immunoassay using 4G10E2 and IBA493 as antibodies, a synthetic tau peptide as calibrator, and the Quanterix SP-X imager. Analytical validation performed in a College of American Pathologists-accredited CLIA laboratory involved multiple kit lots, operators, timepoints, and imagers. Florbetapir positron emission tomography was used to quantify amyloid for clinical validation.

Results
Precision across 80 runs was ≤20% CV using 23 patient-derived samples ranging from 0.09 U/mL to 3.35 U/mL. No significant lot-to-lot differences were observed. There was no interference from purified tau (2N4R) or lipemia, but hemolysis greater than 2 + was not acceptable. Functional analytical sensitivity (lower limit of quantitation) was 0.08 U/mL. Linearity studies support the use of a standard 1:2 plasma dilution. Samples demonstrated stability at 7 freeze/thaw cycles, with room temperature and refrigerated stability established for up to 72 hours. The final analytical measurement range was 0.08 to 2.81 U/mL. The calibration curve maintained ≤20% CV for raw signal intensity and 80% to 120% relative error for back-fitted concentration using a log-log power regression. Initial clinical assessment using plasma samples from 1091 individuals screened in TRAILBLAZER-ALZ 2 demonstrated an area under the curve of 91.6% (95% CI 0.90–0.94) with brain amyloid as the comparator. Positive and negative predictive value was &gt;90% and &gt;85%, respectively.

Conclusions
Through analytical validation, this assay demonstrated robust performance across multiple lots, operators, and instruments and could be used as a tool for diagnosing AD.
Prevalence, predictors and natural history of hypophosphatemia following iron infusion
Authors: Dawson Chloe , Pak Lai-Ming Kathleen , Paul Eldho , Szwarcbard Naomi , Hackman Kathryn 
Published: January 2025

Abstract
Iron deficiency is the leading cause of anemia, which affects one quarter of the adult population globally. Intravenous iron is a well-established treatment option and is generally well tolerated. However, there is increasing recognition that it can cause hypophosphatemia, which can result in fatigue, nausea, myalgia, weakness and osteomalacia. We sought to determine the prevalence, natural history and predictors of hypophosphatemia following iron infusion in a tertiary hospital. All adult patients who received one or more iron infusions between January 1st 2019 to December 31st 2021 were included in this retrospective study. 2367 subjects were identified, receiving a total of 7063 infusions over the study period. Hypophosphatemia was defined as a serum phosphate level of &lt;0.75 mmol/L (&lt;2.32 mg/dL), with severity classified as mild 0.65-0.75 mmol/L (2.01-2.31 mg/dL), moderate 0.32-0.64 mmol/L (0.99-1.98 mg/dL), or severe &lt;0.32 mmol/L (&lt;0.99 mg/dL). Prevalence of hypophosphatemia was 48.9%, with the highest prevalence from day 4 to 20 post-iron infusion (39.3-44.1%). Risk factors were receipt of iron polymaltose (OR 2.33, CI 1.71-3.19, P&lt;.0001), receipt of ferric carboxymaltose (OR 1.79, CI 1.29-2.48, P=.001), male gender (OR 1.35, CI 1.09-1.66, P=.006) and multiple iron infusions (OR 1.56, CI 1.20-2.03, P=.001). Risk was reduced in recipients with higher baseline phosphate (OR 0.18, CI 0.11-0.28, P&lt;.0001), higher baseline creatinine (OR 0.83, CI 0.74-0.92, P=.001) and increased weight (OR 0.99, CI 0.99-1.00, P=.016). Risk factors for moderate to severe hypophosphatemia were the same, except that gender became non-significant, while increasing age (OR 0.99, CI 0.99-1.00, P=.002) was also associated with reduced risk. These findings may aid clinicians in identifying those at greatest risk of developing significant hypophosphatemia, thereby preventing adverse outcomes.
Comparison of colored sticky traps for Stomoxys calcitrans (Diptera: Muscidae) on dairy cattle farms in Saraburi province, Thailand
Authors: Phasuk Jumnongjit , Jhaiaun Pairpailin , Rungchalermlak Chattraporn , Nguyen Giang Thi , Chimnoi Wissanuwat , Tongyoo Pumipat , Kamyingkird Ketsarin 
Published: January 2025

Abstract
A sticky trap is a simple, low-cost method for the field estimation of insect population density. The present study was investigated the attraction of Stomoxys calcitrans using 5 different colors of sticky trap (blue, gray, transparent, white, and yellow). Throughout the sampling period, the sticky traps collected 1,559 S. calcitrans adults, of which 560 (36%) were females and 999 (64%) were males. The mean numbers of S. calcitrans on the 3 dairy cattle farms sampled differed significantly among the different trap colors, with both sexes being preferentially attracted to white or blue sticky traps. However, the white sticky traps were more effective at trapping S. calcitrans than the yellow and transparent sticky traps. Thus, a white-colored fly trap design was recommended for monitoring purposes.
Impact of hilling timing on soybean gall midge (Diptera: Cecidomyiidae) abundance, plant injury, and yield
Authors: Gupta Pragya , McMechan Anthony Justin 
Published: January 2025

Abstract
In 2019, the soybean gall midge (Resseliella maxima Gagné) was identified as a new pest and species in the US Midwest, causing injury to soybean (Glycine max (L.) Merr.). Infestation of R. maxima in soybean starts with females laying eggs in the fissures or cracks that develop at the base of soybean at the V2 growth stage. These fissures can be found on soybean from the soil surface to the cotyledonary node. After eggs hatch, larvae feed inside the stem, leading to wilting and death of the plants. In 2021, hilling was tested as a cultural tactic at the V2 stage, where soil was placed at the base of stems covering the fissures, resulting in a reduction in soybean gall midge infestation. To better understand this cultural control practice, hilling was performed at different timings at different vegetative (V2, V5) and reproductive (R2) soybean growth stages during the 2022 and 2023 growing seasons. We hypothesized that a greater abundance of larvae and increased plant injury would occur with later hilling applications. The results showed that soybean hilled at V2 and V5 stages had a lower infestation and higher yields compared to hilling later. The results of this study demonstrate that hilling during vegetative growth stages can reduce R. maxima infestation and prevent yield loss.
Multiscale wave equation reflection traveltime inversion based on time-lag method
Authors: Zhang Xinwen , Huang Jianping , Li Yuanyuan , Li Zhenchun 
Published: January 2025

Abstract
As a high accuracy velocity reconstructed method, full waveform inversion (FWI) has been widely applied in geophysical exploration due to the full use of seismic wave information. A notable challenge associated with FWI is the poor precision of initial velocity model. FWI with constrained offset makes it difficult for diving wave to reach deep layers. Reflection wave traveltime inversion can use the wave path information of reflected wave to build gradient, which has advantages in building deep background velocity field for FWI. However, single time window size can cause mismatch in traveltime shift extraction. In this study, a time-lag based wave-equation reflection traveltime inversion (TLWERTI) method by frequency division is developed to deal with this issue. Firstly, the gradients between time-lag full waveform inversion (TLFWI) and TLWERTI are analyzed to indicate the necessity of time-lag strategy on reflection wave traveltime inversion. Secondly, Sigsbee2a model is used to obtain a background model by TLWERTI. The comparison between the results of background inversion model and linear model in FWI highlights the advantage of this method. Thirdly, to test the robustness of TLWERTI in recovering a background velocity field using low signal-to-noise ratio data, a Marmousi noisy data is simulated. Numerical results show that our research method can obtain more accurate initial velocity for FWI, and make the reconstruction process of mid- to deep- layers background velocity more robust and controllable.
Caecal lipoma causing acute appendicitis—a case report
Authors: Alam Fahreyar , Chikukuza Stewart , Okkeh Omar , Jones Rachel M , Haynes Harry R , Omar Ifrah , Helal Alaa , Tsvetkov Filip 
Published: January 2025

Abstract
Colonic lipoma is a rare mesenchymal tumour of the gastrointestinal tract that is composed of well-differentiated adipose tissue (1). The commonest site of colonic lipomas is the ascending colon (45%), followed by the sigmoid colon (30.3%), descending colon (15.2%), and transverse colon (9.1%) (2). Lipomas of the large intestine represent the third most common benign tumours after hyperplastic and adenomatous polyps (3). They arise from the submucosa in ~90% of cases, but occasionally extend into the muscularis propria; up to 10% are subserosal (3). Colonic lipomas &gt;2 cm may occasionally cause abdominal pain, changes of bowel habits, rectal bleeding, intussusception, bowel obstruction, or prolapse (4). Appendicitis is primarily caused by obstruction of the appendiceal lumen leading to inflammation. In adults, acute appendicitis is commonly attributed to fecaliths, tumours, or infections. In this case we present a patient, who presented with acute appendicitis, secondary to a caecal lipoma.
Perforation of the sigmoid colon with formation of a sigmoido-ureteral fistula caused by an ingested denture: a case report
Authors: Schraps Nina , Korte Joelle C , Willner Antonie , Hackert Thilo , Melling Nathaniel , Mercanoglu Baris 
Published: January 2025

Abstract
Accidentally ingested objects such as dentures can have serious health consequences with damage to the gastrointestinal tract. We report the case of a patient who ingested her dental plate unnoticed, leading to a sigmoid perforation and formation of a sigmoido-ureteral fistula. The patient presented to our emergency department with symptoms 3 months after ingestion. After unsuccessful endoscopic retrieval, a low anterior rectal resection with retrieval of the swallowed denture and resection of the left ureter with subsequent reconstruction surgery was performed.