bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual Port MIMO Slot Antenna with Meander Line for C-and Partial X-Band
Authors: Singh Aditya Kumar , Dwivedi Ajay Kumar , Varma Kalidindi Naga Venkata Suresh , Singh Vivek , Yadav R.S 
Published: March 2023

Abstract
In this communication, a wideband 2-Port Multiple-Input-Multiple-Output (MIMO) antenna of the dimension of 0.13 λ0 × 0.68 λ0 × 0.02 λ0 mm3 (λ0, measured at a lower frequency is 4.43 GHz) is investigated for the C-band and Partial X-Band Applications. The concept of defective ground is introduced to enhance the impedance bandwidth by engraving the rectangular slots. In the proposed configuration a mender line is incorporated as a decoupling network between the antenna elements to enhance the isolation. The quarter wavelength long stepped impedance matched transmission line is used to excite the proposed configurations. The percentage impedance bandwidth of the proposed antenna is 83%. To explore the diversity of the MIMO system the ECC, DG, TARC, and CCL are reported. Excellent agreement between simulation and measured results is obtained, justifying the MIMO antenna's applicability for wireless applications.
The adherence to and utility of the Global Initiative for Chronic Obstructive Lung Disease guidelines for treating COPD among pulmonary specialists: A retrospective analysis
Authors: Alabi Fortune O , Alkhateeb Hadaya A , Zibanayi Mukudzeishe Talent , Garces Jica , DeBarros Kayla M , Benel Pierina S Barletti , Garcia Kayla , James Randall K 
Published: March 2023

Abstract
Background: Despite the evidence-based guidelines promoted by the Global Initiative for Chronic Obstructive Lung Disease (GOLD), the overuse of prescription drugs to manage COPD, particularly inhaled corticosteroids (ICS), remains a persistent challenge. In this real-world study, we evaluated how patients with COPD were divided into ABCD groups based on the 2017 GOLD guidelines, determined the rate of adherence to the GOLD treatment recommendations, described the rate of ICS usage, and determined the rate of triple therapy (TT) prescription.
Methods: The charts of 2291 patients diagnosed with COPD were retrospectively analyzed, of which 1438 matched the eligibility criteria.
Results: The average patient age was 69.6 ± 10.9 years; 52% of patients were female. The average COPD assessment test (CAT) score was 18.3 ± 9.1. The ABCD breakdown was as follows: group A 19.5%, group B 64.1%, group C 1.8%, and group D 14.6%. All groups, except group D, showed discordance in COPD treatment relative to the proposed GOLD guidelines. Only 18.9% of group A and 26% of group B were treated in concordance with the guidelines. TT was primarily used in group D (63.3%) and overused in groups A (30.6%) and B (47.8%). ICS was overused in all groups, particularly in groups A (56.2%) and B (67.3%).
Conclusion: Studies from the last decade have consistently revealed a lack of conformity between what physicians prescribe and what GOLD guidelines recommend. The excessive usage of ICS, which continues despite all the associated adverse effects and the attributable costs, is concerning. The awareness of GOLD guidelines among primary care physicians (PCPs) and respiratory specialists needs to be improved.
Assessment of Reporting Quality in Randomized Controlled Trials of Acupuncture Combined with Other Treatments for Facial Paralysis with CONSORT Statement and STRICTA Standard
Authors: Gu Yena , Zhou Wenhui , Ding Xueying , Yu Zelin , Chen Junkang , Su Caixia , Xuan Lihua 
Published: March 2023

Abstract
Objective: The current study aims to assess the reporting quality and its correlation with randomized controlled trials (RCTs) on acupuncture associated with other treatments for facial paralysis.
Methods: Original articles were retrieved from the China National Knowledge Infrastructure (CNKI), the China Science and Technology Journal Database (VIP), the Wanfang Database (WF), SinoMed, PubMed, and the Web of Science (WOS). The literature was published between 2020 and 2021 in Chinese and English.
Results: A total of 22 articles were included, and the reporting rate of CONSORT items for 22 RCTs ranged from 16.22% to 40.54%. There were 23 entries with a reporting rate below 10%. Additionally, the reporting rate of STRICTA entries for the 22 RCTs ranged from 41.18% to 94.12%. Of all the STRICTA entries, five entries reported rates below or equal to 50%. No literature complies with the CONSORT statement, and none satisfies the STRICTA standard.
Conclusion: The quality of randomized controlled trials of acupuncture combined with other treatments for facial paralysis was generally low. The future trial design of acupuncture and other methods for facial paralysis should be standardized to improve the reporting quality based on the CONSORT statement and the STRICTA standard.
Polymeric nature of tandemly repeated genes enhances assembly of constitutive heterochromatin in fission yeast
Authors: Yamamoto Tetsuya , Asanuma Takahiro , Murakami Yota 
Published: March 2023

Abstract
Heterochromatin has been thought to be assembled by phase separation of chromatin. However, a fission yeast has only three chromosomes and the heterochromatin of this organism is not likely to be assembled by phase separation, which is a collective phenomenon of many chains. Motivated by our recent experiments that demonstrate that the tandemly repeated genes become heterochromatin, we constructed a theory of heterochromatin assembly by taking into account the connectivity of these genes along the chromatin in the kinetic equations of small RNA production and histone methylation, which are the key biochemical reactions involved in the heterochromatin assembly. Our theory predicts that the polymeric nature of the tandemly repeated genes ensures the steady production of small RNAs because of the stable binding of nascent RNAs produced from the genes to RDRC/Dicers at the surface of nuclear membrane. This theory also predicts that the compaction of the tandemly repeated genes suppresses the production of small RNAs, consistent with our recent experiments. This theory can be extended to the small RNA-dependent gene silencing in higher organisms.
A Conceptual Blockchain-Based Framework for Secure Industrial IoT Remote Monitoring: Proof of Concept
Authors: Ghaderi Mohammad Reza , Ghahyazi Ali Eghbali 
Published: March 2023

Abstract

There is currently a lot of research going on using blockchain in Industrial Internet of Things (IIoT) applications. Secure real-time data monitoring is one of the requirements of IIoT. Although blockchain is a suitable platform for secure remote monitoring in IIoT due to its features, however, if the goal is real time monitoring, then the issue of data packet loss can be raised as a challenge. In this study, we present a conceptual platform based on Hyperledger Fabric blockchain (HFB) for secure real time remote monitoring in IIoT. To prove this concept, we implemented an HFB network consisting of a number of machines and monitored simulated data packets. By conducting various experiments, we evaluated the performance of the HFB network for secure real time data monitoring in terms of data packet loss. The results of the experiments show that in blockchain-based real-time monitoring, the generation period of transactions should be greater than or equal to the block generation time to avoid the packet loss in the network. The results of the research can be used in the practical implementation of blockchain-based real-time industrial data monitoring in IIoT systems.
Flipped online teaching of histology and embryology with design thinking: Design, practice and reflection
Authors: Guo Yan , Wang Xiaomei , Gao Yang , Yin Haiyan , Ma Qun , Chen Ting 
Published: March 2023

Abstract

Background
Flexible hybrid teaching has become the new normal of basic medical education in the postepidemic era. Identifying ways to improve the quality of curriculum teaching and achieve high-level talent training is a complex problem that urgently needs to be solved. Over the course of the past several semesters, the research team has integrated design thinking (DT) into undergraduate teaching to identify, redesign and solve complex problems in achieving curriculum teaching and professional talent training objectives.
Methods
After attempting online and offline hybrid traditional teaching, the aim of the research is to study the positive attempt of online flipped teaching using two selected course chapters. The research team redesigned the curriculum and evaluation method involved in teaching these chapters and implemented them in accordance with this new curriculum, aiming at the problems uncovered in the initial attempts. Thus, the curriculum and questionnaire should have shown improvement, and iterative products should have been applied in a timelier manner in the later attempts at flipped teaching. The selected sample comprised the Jining Medical College (JNMC) undergraduate oral (112 students) and nursing (44 students) classes. Student performance was measured according to the questionnaire results, student feedback and course grades. GraphPad Prism software was used for data analysis, and the statistical method was conducted by multiple or unpaired t test.
Results
Most students report a positive attitude towards the teaching model, and nearly 80% of students reported exercising multiple abilities while learning the material. This further iteration of the design scheme improves the teaching effect of online flipped classrooms. The exam scores for flipped teaching chapters increase markedly in flipped classrooms, and the difference is statistically significant.
Conclusion
Online flipped teaching is an effective means of integrating DT into the flexible and mixed teaching of Health Education (HE), and it can effectively enhance students' learning input and cultivate students' autonomous learning ability. This research reshapes the approach to classroom teaching through the deep integration of modern information technology into educational philosophy. Future work should explore the optimal proportion by which to appropriately expand the scope of flipped teaching content.
Diagnostic and predictive values of ferroptosis-related genes in heart failure
Authors: Li Sheng , Guo Yanli , Zhang Aimei , Ma Ketao , Wang Li 
Published: March 2023

Abstract
Background: Heart failure is a complex clinical syndrome, and there is growing evidence that ferroptosis is related to heart failure. This study sought to identify a new diagnostic model for ferroptosis-related genes in heart failure patients and analyze the signature genes associated with ferroptosis in heart failure.
Methods: The ferroptosis-related genes were found on the FerrDbwebsite, and the heart failure microarray datasets (GSE5406, GSE57338, GSE1145) were screened from the GEO database. The "limma" package in R software was then used to analyze the ferroptosis-related differentially expressed genes (DEGs), and functional enrichment analysis was carried out for ferroptosis-related DEGs. The differentially expressed ferroptosis-related genes were then screened using LASSO regression and SVM-RFE algorithms. The intersection was then used to get the signature genes. The signature genes served as the foundation for the diagnostic model. The diagnostic model was created using a nomogram and receiver operating characteristic curve (ROC), and the model's precision was assessed. The expression of the signature genes' signaling pathways was examined using GSEA. The CIBERSORT algorithm was then used to analyze immune cell infiltration and correlation analysis in the immune systems of heart failure patients. Finally, the testing set was used to evaluate the diagnostic and predictive value of signature genes in heart failure.
Results: The training set (GSE5406) was used to screen 127 ferroptosis-related differentially expressed genes, including 44 up-regulated and 83 down-regulated genes. Ferroptosis was significantly enriched for genes that were differentially expressed according to KEGG analysis, and oxidative stress was significantly enriched in genes according to GO-BP analysis. A diagnostic model and nomogram were successfully constructed based on the five differential genes with an area under the curve (AUC):0.952 (95% CI: 0.894-0.993), using the diagnostic model to differentiate between the normal control group and the heart failure group. Five ferroptosis-related differential genes (BECN1, SLC39A14, QSOX1, DAZAP1, TMSB4X) were screened and identified. Additionally, CD4-naive T cells were discovered to be related to heart failure patients. Finally, the diagnostic performance in the testing set (GSE57338, GSE1145) was confirmed, further demonstrating the accuracy and reliability of the study's findings.
Conclusion: A novel diagnostic model with significant value for heart failure was successfully established after five ferroptosis-related genes were screened and identified. Additionally, it might be beneficial for treating patients with heart failure and aid in understanding the part ferroptosis plays in the pathogenesis of the condition.
Depression and Self-Esteem Among Afghan School-Going Adolescents
Authors: Neyazi Ahmad , Padhi Bijaya Kumar , Ahmadi Mahsa , Rangelova Vanya , Mohammadi Ab. Qadim , Neyazi Mehrab , Griffiths Mark D. 
Published: March 2023

Abstract
Background: During the period of adolescence, several major developmental changes occur that can have significant impact on an individual’s brain structure and functioning through their entire life. The present study examined the association between depression and self-esteem alongside specific sociodemographic factors among school-going adolescents living under the rule of Taliban.
Methods: A cross-sectional survey study was conducted with adolescents (n=452) from 20 randomly selected public primary, secondary and high schools of Herat province (Afghanistan) out of the 86 schools registered in Herat Education Department.
Results: Two-thirds of adolescents reported depression symptoms (65.3%) and 86.3% reported poor self-esteem. Multiple regression analysis indicated that (i) mother's education level was significantly associated with depression symptoms and (ii) low-income economic status was significantly associated with self-esteem.
Conclusion: As well as being one of the few studies in Afghanistan, the present study is one of the very few to assess the association between class group, self-esteem, and depression symptoms. These findings may be used by healthcare authorities and school administrators to raise awareness and implement strategies to facilitate self-esteem among school school-going adolescents.
Adsorption of Rose Bengal dye from waste water onto modified biomass
Authors: Hassan Mohammed G. , Wassel Magdy A. , Gomaa Hosni A. , Elfeky Ahmed S. 
Published: March 2023

Abstract
The adsorption of rose Bengal dye (RB) from aqueous solution investigated in this work. Unmodified and modified nano orange peel has been praised for their extraordinary capacity to bind with dyes. Nano raw orange peel (OP) underwent carbonization to obtain nano orange peel activated carbon (AC). Nano activated carbon coated with nano chitosan (Cs) to obtain nano chitosan/activated carbon (AC/Cs) which decorated with carboxylated multi-walled carbon nanotubes (MWCNTs-COOH) via polymer crosslinking method to create unique featured and the most effective composite (OP/AC/Cs/MWCNTs). These materials tested using FTIR, XRD, SEM and TEM. Herein, for nano raw orange peel and nano composite, batch experiments studied the effect of the RB dye initial concentration, pH of the medium, temperature. Furthermore, sorption isotherms, kinetics and thermodynamics were investigated. Additionally, thermodynamic calculations are made for parameters such as entropy (ΔS), enthalpy (ΔH), standard free energy (ΔG), sticking probability (S*) and activation energy (Ea). For the acquired data, Langmuir isotherm and pseudo-second order models were the preferred fitting. Also, the adsorption of rose Bengal dye is exothermic and spontaneous.
Planning a Reliable Hospital-Wide Cleaning Workforce
Authors: Joe Viana , Daniel Gartner 
Published: March 2023

Abstract
Background: Every year, tens of thousands of patients die world-wide because of infections associated with the health system. One source of hospital-acquired infections which reportedly have reached prevalence levels of 7-10%, are poor hygiene measures. These can be addressed, among others, by scheduling a reliable hospital cleaning workforce, responsive to hospital requirements and safety standards.
Methods: To model the problem, we develop a hybrid simulation model which captures features such as variation in demand as well as cleaning durations. Our model enables us to evaluate the current workforce schedule from a collaborating European hospital using a variety of performance metrics (e.g., waiting time for ad-hoc cleaning jobs) and levels of detail (e.g., response time broken down by time of day). Using a mixed-integer linear programming approach, we generate alternative schedules.
Results: Our results indicate substantial improvements as compared to current planning: While the baseline workforce planning model with 13 cleaners sometimes fails to adequately cope with the demand, the demand coverage can be improved substantially with reshuffling the same number of cleaners.
Conclusions: Using our simulation model and the MIP approach, hospital managers can provide a more reliable and safer environment for patients and staff.
Refining the serum miR-371a-3p test for viable germ cell tumor detection: identification and definition of an indeterminate range
Authors: Lafin John , Scarpini Cinzia , Amini Armon , Konneh Bendu , Howard Jeffrey , Gerald Thomas , Nuno Michelle , Piao Jin , Savelyeva Anna , Wang Zhaohui , Gagan Jeffrey , Jia Liwei , Lewis Cheryl , Murray Sarah , Sawa Yun , Margulis Vitaly , Woldu Solomon , Strand Douglas , Coleman Nicholas , Amatruda James , Frazier Lindsay , Murray Matthew , Bagrodia Aditya 
Published: March 2023

Abstract
Circulating miR-371a-3p has excellent performance in the detection of viable (non-teratoma) GCT pre-orchiectomy; however, its ability to detect occult disease is understudied. To refine the serum miR-371a-3p assay in the minimal residual disease setting we compared performance of raw (Cq) and normalized (∆Cq, RQ) values from prior assays, and validated interlaboratory concordance by aliquot swapping. Revised assay performance was determined in a cohort of 32 patients suspected of occult retroperitoneal disease. Assay superiority was determined by comparing resulting receiver-operator characteristic (ROC) curves using the Delong method. Pairwise t-tests were used to test for interlaboratory concordance. Performance was comparable when thresholding based on raw Cq vs. normalized values. Interlaboratory concordance of miR-371a-3p was high, but reference genes miR-30b-5p and cel-miR-39-3p were discordant. Introduction of an indeterminate range of Cq 28–35 with a repeat run for any indeterminate improved assay accuracy from 0.84 to 0.92 in a group of patients suspected of occult GCT. We recommend that serum miR-371a-3p test protocols are updated to a) utilize threshold-based approaches using raw Cq values, b) continue to include an endogenous (e.g., miR-30b-5p) and exogenous non-human spike-in (e.g., cel-miR-39-3p) microRNA for quality control, and c) to re-run any sample with an indeterminate result.
Impact of low-dose prasugrel on platelet reactivity in chronic phase of post-percutaneous coronary intervention (CHAPERON): a prospective cohort study
Authors: Fukase Tatsuya , Doi Shinichiro , Dohi Tomotaka , Koike Takuma , Nishio Ryota , Yasuda Hidetoshi , Takeuchi Mitsuhiro , Takahashi Norihito , Chikata Yuichi , Endo Hirohisa , Nishiyama Hiroki , Okai Iwao , Iwata Hiroshi , Okazaki Shinya , Daida Hiroyuki , Suwa Satoru , Minamino Tohru , Miyauchi Katsumi 
Published: March 2023

Abstract
Purpose Asians often face the problems of clopidogrel resistance and East Asian paradox. This study aimed to evaluate the effects of P2Y12 inhibitors, including low-dose prasugrel 2.5 mg, on the P2Y12 reaction unit (PRU)

in the chronic phase after percutaneous coronary intervention (PCI). Methods A total of 348 patients were studied. PRU was measured 6-12 months after PCI and subsequently, 6 months later using a P2Y12 assay, respectively. This study evaluated the proportion of bleeding risk (PRU ≤85) and ischemic risk (PRU ≥239) as primary endpoints, and the prediction of bleeding risk and ischemic risk using multivariable logistic regression analysis. Results At baseline, 136 patients (39%) received prasugrel 3.75 mg, 48 patients (14%) received prasugrel 2.5 mg, and 164 patients (47%) received clopidogrel 75 mg. Clopidogrel 75 mg had a significantly higher proportion of ischemic risk within one year after PCI than the other groups, and was an independent predictor for ischemic risk with reference of prasugrel 3.75 mg. In addition, switching from clopidogrel 75 mg to prasugrel 2.5 mg significantly lowered and aggregated the PRU value. Whereas, dose reduction of prasugrel had a significantly lower proportion of bleeding risk over one year after PCI than the continuation of prasugrel 3.75 mg, and was an independent predictor for bleeding risk with reference of continuation of prasugrel 3.75 mg. Conclusions Prasugrel 2.5 mg has a lower ischemic risk and a more stable PRU value compared with clopidogrel treatment. Prasugrel also contributes to a decline in bleeding risk with concomitant dose reduction.
Trial registration : University Hospital Medical Information Network (UMIN),
ID : UMIN000029541, Date : October 16, 2017 (https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033395)
Phyllosticta taxa from northern Thailand and southern European Russia: a novel species and four new host records
Authors: Gomdola Deecksha , Jayawardena Ruvishika Shehali , McKenzie Eric H.C. , Bulgakov Timur S. , Wanasinghe Dhanushka N. , Huanraluek Naruemon , Hyde Kevin David 
Published: March 2023

Abstract
Phyllosticta is a cosmopolitan group of fungi found on various host plants, occurring as pathogens, endophytes and saprobes. Diseases caused by Phyllosticta commonly include leaf and fruit spots that affect economically important plants. The genus is characterized mainly by aseptate and hyaline conidia and ascospores. However, its conidia are surrounded by a mucilaginous sheath, with a single mucoid apical appendage while ascospores exhibit a mucoid cap at both ends. Given that many Phyllosticta taxa are cryptic and share similar morphological features, it is arduous to depict taxonomically relevant characters solely on the basis of morphological and ecological features. Coupled with morphological description, multi-locus phylogenetic analyses of species comprising complexes are used to broadly describe this genus and understand species boundaries. Despite several published taxonomic revisions and enumerations of Phyllosticta species, there is still considerable confusion when identifying these taxa. Herein, we introduce a new species (P. chiangmaiensis) and three new host records (P. capitalensis) in Thailand, and one new host and country record (P. citribrasiliensis) in Russia. We provide an updated phylogenetic tree, including all Phyllosticta species with sequence data.