bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Pengolahan dan Analisis Usaha Mangga Kering (Dried Mango) di Desa Sumberagung Kecamatan Banjarejo Kabupaten Blora
Authors: Saputri Romadhiyana Kisno , Rachmawati Ulvina , Ningrum Ifa Khoiria , Sari Novi Arum , Mutiani Tia 
Published: February 2023

Kemiskinan memiliki kecenderungan untuk menyebabkan ketidakcukupan konsumsi gizi yang berhubungan dengan tingginya kejadian stunting balita serta dapat menyebabkan gangguan mental seperti depresi dan gangguan kepribadian. Salah satu upaya untuk mencegah kemiskinan dan meningkatkan ekonomi dapat dilakukan dengan memberikan pelatihan pemanfaatan sumber daya lokal. Di Desa Sumberagung salah satu sumberdaya yang dapat dimanfaatkan adalah buah mangga. Olahan mangga yang mudah dibuat dan murah bahan bakunya adalah mangga kering (dried mango). Kegiatan pengabdian kepada masyarakat ini bertujuan untuk melakukan pelatihan pembuatan mangga kering (dried mango) dan melakukan analisis usaha produk mangga kering (dried mango). Kegiatan dilakukan menggunakan metode ceramah dan praktik langsung atau demonstrasi dengan sasaran 30 ibu-ibu PKK. Pengetahuan pembuatan mangga kering (dried mango) meningkat 100%, keterampilan pembuatan mangga kering (dried mango) meningkat 83,3%. Analisis usaha produk mangga kering (dried mango) menunjukkan BC Ratio 3,33 yang berarti usaha dapat dijalankan dengan layak. Kegiatan pelatihan pembuatan mangga kering (dried mango) di Desa Sumberagung Kecamatan Banjarrejo Kabupaten Blora berjalan dengan lancar serta menunjukkan adanya peningkatan pengetahuan dan keterampilan sasaran dalam pembuatan mangga kering (dried mango) serta tentang analisis usaha produk mangga kering (dried mango).
PENDIDIKAN INKLUSIF DI PERGURUAN TINGGI: ANTARA PELUANG DAN TANTANGAN
Authors: Yusuf Muhamad 
Published: February 2023

The education system in Indonesia does not yet accommodate diversity, so that led to the emergence of segmentation educational institutions based on religious differences, ethnic, and even differences in physical and mental abilities of students. During this time the children who have different capabilities provided special educational facilities with fixesthe level and type of disabilities called Extraordinary School (SLB). Unconsciously education system SLB has built an exclusive wall for children with special needs. Inclusive education is an education that provides opportunities for children with disabilities or special needs to equally have the opportunity to learn alongside normal children. All children should be able to learn together regardless of any difficulties or differences they may have on them. The inclusion of education as a solution to termarjinalkannya raised millions of children from education because of the background of gender, religion, ethnicity, culture, language, physical and intellectual abilities (disability), geographic location, or social and economic conditions Sistem pendidikan di Indonesia belum mengakomodir keberagaman, sehingga menyebabkan munculnya segmentasi lembaga pendidikan yang berbasis pada perbedaan agama, etnis, dan bahkan perbedaan kemampuan baik fisik maupun mental siswa. Selama ini anak–anak yang memiliki perbedaan kemampuan disediakan fasilitas pendidikan khusus disesuaikan dengan tingkat dan jenisnya yang disebut dengan Sekolah Luar Biasa (SLB). Secara tidak disadari sistem pendidikan SLB telah membangun tembok eksklusifisme bagi anak–anak yang berkebutuhan khusus. pendidikan inklusi adalah sebuah pendidikan yang memberikan kesempatan kepada anakanak yang cacat atau berkebutuhan khusus untuk sama-sama memperoleh kesempatan belajar bersama anak-anak normal lainnya. Semua anak seyogyanya bisa belajar bersama-sama tanpa memandang kesulitan ataupun perbedaan yang mungkin ada pada diri mereka. Pendidikan inklusi ini dimunculkan sebagai solusi atas termarjinalkannya berjuta anak dari pendidikan karena latar belakang jender, agama, etnik-budaya, bahasa, kemampuan fisik dan intelektual lokasi geografis, dan atau kondisi sosial dan ekonomi.
INDONESIA’S STRATEGY AND DIPLOMACY IN THE SOUTH CHINA SEA CONFLICT
Authors: Mustofa Ahmad Zainal 
Published: February 2023

<p>This study describes the government's strategy in Indonesia under the leadership of Joko Widodo to strengthen the Natuna border area. The Natuna area is a point of discussion as there are often territorial conflicts. This study aims to answer the question about the government's strategy to strengthen the border zone in Natuna. This study uses library research methodology and the Revolution in Military Affairs (RMA) concept to analyze the process. After conducting research, it can be concluded that to reinforce the border area at Natuna, the government is making efforts to improve the military posture by constructing several new military units. Then the government is also looking at diplomatic means in the ASEAN region to resolve the territorial dispute with China in the South China Sea. This is because there is no mutual agreement, considering that Indonesia is based on the 1982 UNCLOS, while China has a view of the Nine-Dash Line. </p>
SECURITY ANALYSIS ON WEBSITES USING THE INFORMATION SYSTEM ASSESSMENT FRAMEWORK (ISSAF) AND OPEN WEB APPLICATION SECURITY VERSION 4 (OWASPv4) USING THE PENETRATION TESTING METHOD
Authors: Anggraeni Ditya Putri , Zen Bita Parga , Pranata Mega 
Published: February 2023

<p>At this time in the rapid development of technology, there must be advantages and disadvantages of a system or technology that was created. Within the scope of the website, there are also many security holes that irresponsible parties can enter. The state of the website at the Telkom Purwokerto Institute of Technology, both University and Faculty websites, already uses Hypertext Transfers Protocol Secure (HTTPS). This study used the Information System Security Assessment Framework (ISSAF) and Open Web Application Project (OWASP) frameworks with the Penetration Testing method. This study aims to determine vulnerabilities on the website s1if.ittelkom-pwt.ac.id. The result of performing vulnerabilities is several vulnerabilities to the Institut Teknologi Telkom Purwokerto (ITTP) Informatics Study Program website, including not updating jquery on the ITTP website. Ten tests have been carried out, five tests using ISSAF and five tests using OWSP version 4. When performing vulnerabilities in the ISSAF framework, found robots files.txt on the S1 Informatics website which is quite crucial for s1if.ittelkom-pwt.ac.id website which contains an exploitable sitemap. </p>
INDONESIA–AUSTRALIA MARITIME COOPERATION AND ITS IMPLICATION ON INDONESIA’S MARITIME SECURITY AND SOVEREIGNTY
Authors: Pangemanan Arcelinocent Emile , Perwita Anak Agung Banyu , Sudibyo Sudibyo 
Published: February 2023

<p>Global Maritime Fulcrum (GMF) has provided a roadmap for realizing Indonesia’s maritime security and sovereignty with an active contribution regionally and globally. The research method used in this research is content analysis, which is an approach in qualitative research that in research that refers to systematic data and text collections that can be managed to support the research itself. The rise of transnational maritime crime has a major impact on why Indonesia and Australia are keen on building trust through maritime cooperation, for it has the potential to disrupt and threaten national development, therefore this research aims to the mapped diplomatic mechanism through GMF, as a framework that hostess Indonesia–Australia Maritime Cooperation and its plan of actions in ensuring Indonesia’s maritime security and sovereignty. The maritime cooperation between Indonesia and Australia has improved the integrated defense and security capabilities of both countries through capacity building, although the plan of action will end in 2022, therefore harnessing the longevity of the maritime cooperation is considered crucial. </p>
Biomimetic cardiac tissue chip and murine arteriovenous fistula models for recapitulating clinically relevant cardiac remodeling under volume overload conditions
Authors: Waldrop Tatyana Isayeva , Graham Caleb , Gard William , Ingle Kevin , Ptacek Travis , Nguyen Nguyen , Lose Bailey , Sethu Palaniappan , Lee Timmy 
Published: February 2023

Cardiovascular events are the primary cause of death among dialysis patients. While arteriovenous fistulas (AVFs) are the access of choice for hemodialysis patients, AVF creation can lead to a volume overload (VO) state in the heart. We developed a three-dimensional (3D) cardiac tissue chip (CTC) with tunable pressure and stretch to model the acute hemodynamic changes associated with AVF creation to complement our murine AVF model of VO. In this study, we aimed to replicate the hemodynamics of murine AVF models in vitro and hypothesized that if 3D cardiac tissue constructs were subjected to “volume overload” conditions, they would display fibrosis and key gene expression changes seen in AVF mice. Mice underwent either an AVF or sham procedure and were sacrificed at 28 days. Cardiac tissue constructs composed of h9c2 rat cardiac myoblasts and normal adult human dermal fibroblasts in hydrogel were seeded into devices and exposed to 100 mg/10 mmHg pressure (0.4 s/0.6 s) at 1 Hz for 96 h. Controls were exposed to “normal” stretch and experimental group exposed to “volume overload”. RT-PCR and histology were performed on the tissue constructs and mice left ventricles (LVs), and transcriptomics of mice LVs were also performed. Our tissue constructs and mice LV both demonstrated cardiac fibrosis as compared to control tissue constructs and sham-operated mice, respectively. Gene expression studies in our tissue constructs and mice LV demonstrated increased expression of genes associated with extracellular matrix production, oxidative stress, inflammation, and fibrosis in the VO conditions vs. control conditions. Our transcriptomics studies demonstrated activated upstream regulators related to fibrosis, inflammation, and oxidative stress such as collagen type 1 complex, TGFB1, CCR2, and VEGFA and inactivated regulators related to mitochondrial biogenesis in LV from mice AVF. In summary, our CTC model yields similar fibrosis-related histology and gene expression profiles as our murine AVF model. Thus, the CTC could potentially play a critical role in understanding cardiac pathobiology of VO states similar to what is present after AVF creation and may prove useful in evaluating therapies.
Pre-percutaneous coronary intervention sudden cardiac arrest in ST-elevation myocardial infarction: Incidence, predictors, and related outcomes
Authors: Machado Guilherme Pinheiro , Theobald Andre Luiz , de Araujo Gustavo Neves , Silveira Anderson Donelli da , Wainstein Rodrigo Vugman , Fracasso Julia Fagundes , Niches Matheus , Chies Angelo , Goncalves Sandro Cadaval , Pimentel Mauricio , Wainstein Marco Vugman 
Published: February 2023

BackgroundST-segment elevation myocardial infarction (STEMI) is a frequent cause of sudden cardiac arrest (SCA) and early percutaneous coronary intervention (PCI) is associated with increased survival. Despite constant improvements in SCA management, survival remains poor. We aimed to assess pre-PCI SCA incidence and related outcomes in patients admitted with STEMI.MethodsThis was a prospective cohort study of patients admitted with STEMI in a tertiary university hospital over 11  years. All patients were submitted to emergency coronary angiography. Baseline characteristics, details of the procedure, reperfusion strategies, and adverse outcomes were assessed. The primary outcome was in-hospital mortality. The secondary outcome was 1-year mortality after hospital discharge. Predictors of pre-PCI SCA was also assessed.ResultsDuring the study period 1,493 patients were included; the mean age was 61.1 years (±12), and 65.3% were male. Pre-PCI SCA was present in 133 (8.9%) patients. In-hospital mortality was higher in the pre-PCI SCA group (36.8% vs. 8.8%, p &lt; 0.0001). In multivariate analysis, anterior MI, cardiogenic shock, age, pre-PCI SCA and lower ejection fraction remained significantly associated with in-hospital mortality. When we analyzed the interaction between pre-PCI SCA and cardiogenic shock upon admission there is a further increase in mortality risk when both conditions are present. For predictors of pre-PCI SCA, only younger age and cardiogenic shock remained significantly associated after multivariate analysis. Overall 1-year mortality rates were similar between pre-PCI SCA survivors and non-pre-PCI SCA group.ConclusionIn a cohort of consecutive patients admitted with STEMI, pre-PCI SCA was associated with higher in-hospital mortality, and its association with cardiogenic shock further increases mortality risk. However, long-term mortality among pre-PCI SCA survivors was similar to non-SCA patients. Understanding characteristics associated with pre-PCI SCA may help to prevent and improve the management of STEMI patients.
High-resolution structural-functional substrate-trigger characterization: Future roadmap for catheter ablation of ventricular tachycardia
Authors: Stoks Job , Hermans Ben J. M. , Boukens Bas J. D. , Holtackers Robert J. , Gommers Suzanne , Kaya Yesim S. , Vernooy Kevin , Cluitmans Matthijs J. M. , Volders Paul G. A. , ter Bekke Rachel M. A. 
Published: February 2023

IntroductionPatients with ventricular tachyarrhythmias (VT) are at high risk of sudden cardiac death. When appropriate, catheter ablation is modestly effective, with relatively high VT recurrence and complication rates. Personalized models that incorporate imaging and computational approaches have advanced VT management. However, 3D patient-specific functional electrical information is typically not considered. We hypothesize that incorporating non-invasive 3D electrical and structural characterization in a patient-specific model improves VT-substrate recognition and ablation targeting.Materials and methodsIn a 53-year-old male with ischemic cardiomyopathy and recurrent monomorphic VT, we built a structural-functional model based on high-resolution 3D late-gadolinium enhancement (LGE) cardiac magnetic resonance imaging (3D-LGE CMR), multi-detector computed tomography (CT), and electrocardiographic imaging (ECGI). Invasive data from high-density contact and pace mapping obtained during endocardial VT-substrate modification were also incorporated. The integrated 3D electro-anatomic model was analyzed off-line.ResultsMerging the invasive voltage maps and 3D-LGE CMR endocardial geometry led to a mean Euclidean node-to-node distance of 5 ± 2 mm. Inferolateral and apical areas of low bipolar voltage (&lt;1.5 mV) were associated with high 3D-LGE CMR signal intensity (&gt;0.4) and with higher transmurality of fibrosis. Areas of functional conduction delay or block (evoked delayed potentials, EDPs) were in close proximity to 3D-LGE CMR-derived heterogeneous tissue corridors. ECGI pinpointed the epicardial VT exit at ∼10 mm from the endocardial site of origin, both juxtaposed to the distal ends of two heterogeneous tissue corridors in the inferobasal left ventricle. Radiofrequency ablation at the entrances of these corridors, eliminating all EDPs, and at the VT site of origin rendered the patient non-inducible and arrhythmia-free until the present day (20 months follow-up). Off-line analysis in our model uncovered dynamic electrical instability of the LV inferolateral heterogeneous scar region which set the stage for an evolving VT circuit.Discussion and conclusionWe developed a personalized 3D model that integrates high-resolution structural and electrical information and allows the investigation of their dynamic interaction during arrhythmia formation. This model enhances our mechanistic understanding of scar-related VT and provides an advanced, non-invasive roadmap for catheter ablation.
The association between distal symmetric polyneuropathy in diabetes with all-cause mortality – a meta-analysis
Authors: Vági Orsolya E. , Svébis Márk M. , Domján Beatrix A. , Körei Anna E. , Tesfaye Solomon , Horváth Viktor J. , Kempler Péter , Tabák Ádám Gy. 
Published: February 2023

BackgroundDistal symmetric polyneuropathy (DSPN) is a common microvascular complication of both type 1 and 2 diabetes with substantial morbidity burden and reduced quality of life. Its association with mortality is equivocal.PurposeTo describe the association between DSPN and all-cause mortality in people with diabetes and further stratify by the type of diabetes based on a meta-analysis of published observational studies.Data SourcesWe searched Medline from inception to May 2021.Study SelectionOriginal data were collected from case-control and cohort studies that reported on diabetes and DSPN status at baseline and all-cause mortality during follow-up.Data Extractionwas completed by diabetes specialists with clinical experience in neuropathy assessment.Data SynthesisData was synthesized using random-effects meta-analysis. The difference between type 1 and 2 diabetes was investigated using meta-regression.ResultsA total of 31 cohorts (n=155,934 participants, median 27.4% with DSPN at baseline, all-cause mortality 12.3%) were included. Diabetes patients with DSPN had an almost twofold mortality (HR: 1.96, 95%CI: 1.68-2.27, I2 = 91.7%), I2 = 91.7%) compared to those without DSPN that was partly explained by baseline risk factors (adjusted HR: 1.60, 95%CI: 1.37-1.87, I2 = 78.86%). The association was stronger in type 1 compared to type 2 diabetes (HR: 2.22, 95%CI: 1.43-3.45). Findings were robust in sensitivity analyses without significant publication bias.LimitationsNot all papers reported multiple adjusted estimates. The definition of DSPN was heterogeneous.ConclusionsDSPN is associated with an almost twofold risk of death. If this association is causal, targeted therapy for DSPN could improve life expectancy of diabetic patients.
Whole blood transcriptome analysis in dairy calves experimentally challenged with bovine herpesvirus 1 (BoHV-1) and comparison to a bovine respiratory syncytial virus (BRSV) challenge
Authors: O’Donoghue Stephanie , Earley Bernadette , Johnston Dayle , McCabe Matthew S. , Kim Jae Woo , Taylor Jeremy F. , Duffy Catherine , Lemon Ken , McMenamy Michael , Cosby S. Louise , Morris Derek W. , Waters Sinéad M. 
Published: February 2023

Bovine herpesvirus 1 (BoHV-1), is associated with several clinical syndromes in cattle, among which bovine respiratory disease (BRD) is of particular significance. Despite the importance of the disease, there is a lack of information on the molecular response to infection via experimental challenge with BoHV-1. The objective of this study was to investigate the whole-blood transcriptome of dairy calves experimentally challenged with BoHV-1. A secondary objective was to compare the gene expression results between two separate BRD pathogens using data from a similar challenge study with BRSV. Holstein-Friesian calves (mean age (SD) = 149.2 (23.8) days; mean weight (SD) = 174.6 (21.3) kg) were either administered BoHV-1 inoculate (1 × 107/mL × 8.5 mL) (n = 12) or were mock challenged with sterile phosphate buffered saline (n = 6). Clinical signs were recorded daily from day (d) −1 to d 6 (post-challenge), and whole blood was collected in Tempus RNA tubes on d six post-challenge for RNA-sequencing. There were 488 differentially expressed (DE) genes (p &lt; 0.05, False Discovery rate (FDR) &lt; 0.10, fold change ≥2) between the two treatments. Enriched KEGG pathways (p &lt; 0.05, FDR &lt;0.05); included Influenza A, Cytokine-cytokine receptor interaction and NOD-like receptor signalling. Significant gene ontology terms (p &lt; 0.05, FDR &lt;0.05) included defence response to virus and inflammatory response. Genes that are highly DE in key pathways are potential therapeutic targets for the treatment of BoHV-1 infection. A comparison to data from a similar study with BRSV identified both similarities and differences in the immune response to differing BRD pathogens.
Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients
Authors: Bulnes-Ramos Ángel , Pozo-Balado María Mar , Olivas-Martínez Israel , Garrido-Rodríguez Vanesa , Bernal-Blanco Gabriel , Suárez-Benjumea Alejandro , Álvarez-Ríos Ana Isabel , Lozano Carmen , González-Corvillo Carmen , Suñer-Poblet Marta , González-Roncero Francisco Manuel , Sánchez Berta , Maldonado-Calzado Isabel , Lara-Ruiz José Manuel , Gonzalez-Escribano María Francisca , Pacheco Yolanda María 
Published: February 2023

IntroductionKidney transplant recipients showed a weak humoral response to the mRNA COVID-19 vaccine despite receiving three cumulative doses of the vaccine. New approaches are still needed to raise protective immunity conferred by the vaccine administration within this group of high-risk patients. MethodsTo analyze the humoral response and identify any predictive factors within these patients, we designed a prospective monocentric longitudinal study of Kidney transplant recipients (KTR) who received three doses of mRNA-1273 COVID-19 vaccine. Specific antibody levels were measured by chemiluminescence. Parameters related to clinical status such as kidney function, immunosuppressive therapy, inflammatory status and thymic function were analyzed as potential predictors of the humoral response. ResultsSeventy-four KTR and sixteen healthy controls were included. One month after the administration of the third dose of the COVID-19 vaccine, 64.8% of KTR showed a positive humoral response. As predictive factors of seroconversion and specific antibody titer, we found that immunosuppressive therapy, worse kidney function, higher inflammatory status and age were related to a lower response in KTR while immune cell counts, thymosin-a1 plasma concentration and thymic output were related to a higher humoral response. Furthermore, baseline thymosin-a1 concentration was independently associated with the seroconversion after three vaccine doses. DiscussionIn addition to the immunosuppression therapy, condition of kidney function and age before vaccination, specific immune factors could also be relevant in light of optimization of the COVID-19 vaccination protocol in KTR. Therefore, thymosin-a1, an immunomodulatory hormone, deserves further research as a potential adjuvant for the next vaccine boosters.