bluuebunny/crossref_metadata_2025_split huggingface dataset:
Playful educational interventions in children and adolescents’ health literacy: a systematic review
Authors: Ribeiro Synthia Martins , Basso Maurício Bartelle , Massignan Carla , Leal Soraya Coelho 
Published: August 2023

Abstract
There is a need to investigate methods to increase children’s health knowledge. Therefore, the aim of this study was to systematically evaluate the literature on playful educational interventions in health literacy aimed at children aged 6–12 years. For this purpose, the Cochrane Library, EMBASE, LILACS, PubMed, Scopus, Web of Science and grey literature were searched for relevant studies. Randomized, quasi-randomized or non-randomized clinical trials, in which the primary outcome was health literacy in children, were included. Due to the heterogeneity of the studies, the data were qualitatively evaluated. Eleven studies were included in this analysis. Most of the studies were randomized (n = 10). Among the health issues addressed in these studies, obesity prevention was the most studied (n = 5). All participants had low methodological quality, and the most commonly used interventions were games, dramas and theatre plays. Although most studies have pointed to an increase in health knowledge after interventions, it was not possible to determine whether such knowledge was retained over time, whether it effectively changed health behaviours, or if it led to the effective adoption of a healthier lifestyle. Health literacy through playful methods is potentially effective in increasing health knowledge and changing health behaviours. However, literature on its impact on the adoption of healthy lifestyles is inconclusive. Future research with fewer limitations and better methodological designs may help selecting the best intervention strategy to promote health literacy.
Health action process approach: promoting physical activity, and fruit and vegetable intake among Australian adults
Authors: Parkinson Joy , Hannan Thomas , McDonald Nicole , Moriarty Stephanie , Nguyen Tuyet-Mai , Hamilton Kyra 
Published: August 2023

Abstract
Based on the health action process approach (HAPA) this study examined whether changes in social cognition constructs could predict change in physical activity and fruit and vegetable intake for adult participants in My health for life, an Australian health promotion behaviour change program. Variance-based structural equation modelling was used to analyse data obtained from Australian adult program participants (n = 167) at baseline (T1), week 14 (T2), week 26 (T2), and 6-month post-program (T4). Change scores were calculated for the social cognition constructs and behaviour. Changes in action self-efficacy and outcome expectancies positively predicted changes in intentions. Action self-efficacy changes also predicted changes in maintenance self-efficacy which, in turn, mediated the effect of action self-efficacy on recovery self-efficacy and planning. Planning was predicted by changes in intentions and maintenance self-efficacy. Findings support the use of the HAPA model in designing complex health behaviour change interventions to achieve sustained behaviour change.
Uncovering genetic and metabolite markers associated with resistance against anthracnose fruit rot in northern highbush blueberry
Authors: Jacobs MacKenzie , Thompson Samantha , Platts Adrian E , Body Melanie J A , Kelsey Alexys , Saad Amanda , Abeli Patrick , Teresi Scott J , Schilmiller Anthony , Beaudry Randolph , Feldmann Mitchell J , Knapp Steven J , Song Guo-qing , Miles Timothy , Edger Patrick P 
Published: August 2023

AbstractAnthracnose fruit rot (AFR), caused by the fungal pathogen Colletotrichum fioriniae, is among the most destructive and widespread fruit disease of blueberry, impacting both yield and overall fruit quality. Blueberry cultivars have highly variable resistance against AFR. To date, this pathogen is largely controlled by applying various fungicides; thus, a more cost-effective and environmentally conscious solution for AFR is needed. Here we report three quantitative trait loci associated with AFR resistance in northern highbush blueberry (Vaccinium corymbosum). Candidate genes within these genomic regions are associated with the biosynthesis of flavonoids (e.g. anthocyanins) and resistance against pathogens. Furthermore, we examined gene expression changes in fruits following inoculation with Colletotrichum in a resistant cultivar, which revealed an enrichment of significantly differentially expressed genes associated with certain specialized metabolic pathways (e.g. flavonol biosynthesis) and pathogen resistance. Using non-targeted metabolite profiling, we identified a flavonol glycoside with properties consistent with a quercetin rhamnoside as a compound exhibiting significant abundance differences among the most resistant and susceptible individuals from the genetic mapping population. Further analysis revealed that this compound exhibits significant abundance differences among the most resistant and susceptible individuals when analyzed as two groups. However, individuals within each group displayed considerable overlapping variation in this compound, suggesting that its abundance may only be partially associated with resistance against C. fioriniae. These findings should serve as a powerful resource that will enable breeding programs to more easily develop new cultivars with superior resistance to AFR and as the basis of future research studies.
Transcriptomic and genetic approaches reveal that low-light-induced disease susceptibility is related to cellular oxidative stress in tomato
Authors: Luo Qian , Wang Jiao , Wang Ping , Liang Xiao , Li Jianxin , Wu Changqi , Fang Hanmo , Ding Shuting , Shao Shujun , Shi Kai 
Published: August 2023

Abstract
The impact of low light intensities on plant disease outbreaks represents a major challenge for global crop security, as it frequently results in significant yield losses. However, the underlying mechanisms of the effect of low light on plant defense are still poorly understood. Here, using an RNA-seq approach, we found that the susceptibility of tomato to Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) under low light was associated with the oxidation–reduction process. Low light conditions exacerbated Pst DC3000-induced reactive oxygen species (ROS) accumulation and protein oxidation. Analysis of gene expression and enzyme activity of ascorbate peroxidase 2 (APX2) and other antioxidant enzymes revealed that these defense responses were significantly induced by Pst DC3000 inoculation under normal light, whereas these genes and their associated enzyme activities were not responsive to pathogen inoculation under low light. Additionally, the reduced ascorbate to dehydroascorbate (AsA/DHA) ratio was lower under low light compared with normal light conditions upon Pst DC3000 inoculation. Furthermore, the apx2 mutants generated by a CRISPR-Cas9 gene-editing approach were more susceptible to Pst DC3000 under low light conditions. Notably, this increased susceptibility could be significantly reduced by exogenous AsA treatment. Collectively, our findings suggest that low-light-induced disease susceptibility is associated with increased cellular oxidative stress in tomato plants. This study sheds light on the intricate relationship between light conditions, oxidative stress, and plant defense responses, and may pave the way for improved crop protection strategies in low light environments.
CircEXOC5 Aggravates Sepsis-Induced Acute Lung Injury by Promoting Ferroptosis Through the IGF2BP2/ATF3 Axis
Authors: Wang Wei , Xu Rongli , He Ping , Xiong Yuqing , Zhao Haomiao , Fu Xuewei , Lin Jie , Ye Lijiao 
Published: August 2023

Abstract

Background
Patients with sepsis resulting in acute lung injury (ALI) usually have increased mortality. Ferroptosis is a vital regulator in sepsis-induced ALI. Exploring the association of ferroptosis and sepsis-induced ALI is crucial for the management of sepsis-induced ALI.

Methods
Whole blood was collected from sepsis patients. Mice were treated with cecal ligation and puncture (CLP) to model sepsis. Primary murine pulmonary microvascular endothelial cells were treated with lipopolysaccharide as a cell model. Ferroptosis was evaluated by analyzing levels of iron, malonaldehyde, glutathione, nonheme iron, ferroportin, ferritin, and GPX4. Hematoxylin and eosin and Masson's trichrome staining were applied to examine lung injury and collagen deposition. Cell apoptosis was analyzed by caspase-3 activity and TUNEL assays. Gene regulatory relationship was verified using RNA pull-down and immunoprecipitation assays.

Results
CircEXOC5 was highly expressed in sepsis patients and CLP-treated mice, in which knockdown alleviated CLP-induced pulmonary inflammation and injury, and ferroptosis. CircEXOC5 recruited IGF2BP2 to degrade ATF3 mRNA. The demethylase ALKBH5 was responsible for circEXOC5 upregulation through demethylation. CircEXOC5 silencing significantly improved sepsis-induced ALI and survival rate of mice by downregulating ATF3.

Conclusions
ALKBH5-mediated upregulation of circEXOC5 exacerbates sepsis-induced ALI by facilitating ferroptosis through IGF2BP2 recruitment to degrade ATF3 mRNA.
Promoting Diversity and Inclusion in Professional Associations: Experiences from Security Studies
Authors: Rublee Maria Rost , Duncombe Constance , Karavas George , Barma Naazneen H , Idika-Kalu Cecilia , Sotomayor Arturo C , Kalil Mariana , Kang Hye Yun 
Published: August 2023

AbstractThe International Security Studies Section (ISSS) of the International Studies Association aims to promote the study of global, international, regional, and national security—broadly conceived. Over the past decade, ISSS has also sought to improve diversity and inclusion for its membership, culminating in its Taskforce on Diversity in Security Studies. In this forum, taskforce organizers, researchers, and participants examine the ways in which ISSS has collected data and then acted to improve both experiences and outcomes for historically excluded scholars, using an intersectional approach but with a specific focus on race. By critically reflecting on the role of professional associations in combatting racism in academia, using the case study of ISSS, the forum has two aims. First, we hope that by sharing ISSS experiences and processes, we may encourage other professional associations to self-reflect on how they may contribute to racial injustice, as well as how they can reveal and counteract racial oppression. Second, rather than solely focusing on goals and outcomes, the forum also gives voice to personal perspectives of researchers and participants to highlight how it is people who ultimately make up the heart of efforts to challenge racism and discrimination.
Fitness landscape analysis for assisted seismic history matching problems
Authors: Mitchell Paul , Chassagne Romain 
Published: August 2023

AbstractDespite over 20 years of research, assisted seismic history matching (ASHM) remains a challenging problem for the energy industry. ASHM is an optimisation problem to find the best subsurface reservoir model for robust predictions of field performance. The results are typically assessed by a decreasing misfit between simulated and observed data, but the optimised models are often inaccurate, uncertain, and non-unique. In this paper, we take a fresh look at ASHM and view it from the perspective of the fitness landscape, or search space. We propose that characterising the fitness landscape will lead to a deeper understanding of the problem, greater confidence in the optimised models, and a better appreciation of the uncertainties. Fitness landscape analysis (FLA) is established in other fields, but has mostly been applied to combinatorial problems or continuous problems with analytical solutions. In contrast, ASHM is a real-world, ill-posed, inverse problem, which is computationally expensive and contains data errors and model uncertainties. We introduce a new method for FLA that provides intuitive information on the setup of the problem. It uses multidimensional clustering and visualisation to explore the structure of the landscape and detects the presence and relative magnitude of data errors, which are typical of real data. It is applied to a synthetic, full-field, reservoir model and the results are compared with another more-established method. We found that the fitness landscapes of ASHM problems are low-lying plateaus with many minima, which makes it difficult to solve ASHM problems for real-world datasets.
Porosity prediction from prestack seismic data via deep learning: incorporating a low-frequency porosity model
Authors: Liu Jingyu , Zhao Luanxiao , Xu Minghui , Zhao Xiangyuan , You Yuchun , Geng Jianhua 
Published: August 2023

Abstract
Porosity prediction from seismic data is of considerable importance in reservoir quality assessment, geological model building, and flow unit delineation. Deep learning approaches have demonstrated great potential in reservoir characterization due to their strong feature extraction and nonlinear relationship mapping abilities. However, the reliability of porosity prediction is often compromised by the lack of low-frequency information in bandlimited seismic data. To address this issue, we propose incorporating a low-frequency porosity model based on geostatistical methodology, into the supervised convolutional neural network to predict porosity from prestack seismic angle gather and seismic inversion results. Our study demonstrates that the inclusion of the low-frequency porosity model significantly improves the reliability of porosity predictions in a heterogeneous carbonate reservoir. The low-frequency information can be compensated to enhance the network's capabilities of capturing the background porosity trend. Additionally, the blind well tests validate that considering the low-frequency constraint leads to stronger model prediction and generalization abilities, with the root mean square error of the two blind wells reduced by up to 34%. The incorporation of the low-frequency reservoir model in network training also remarkably enhances the geological continuity of seismic porosity prediction, providing more geologically reasonable results for reservoir characterization.
Comparison of neoadjuvant and adjuvant chemotherapy for upper tract urothelial carcinoma in real-world practice: a multicenter retrospective study
Authors: Takahashi Kazuhiro , Urabe Fumihiko , Suhara Yushi , Nakano Juria , Yoshihara Kentaro , Goto Yuma , Sadakane Ibuki , Koike Yuhei , Yata Yuji , Suzuki Hirotaka , Kurawaki Shiro , Miyajima Keiichiro , Iwatani Kosuke , Imai Yu , Sakanaka Keigo , Nakazono Minoru , Kurauchi Takashi , Kayano Sotaro , Onuma Hajime , Aikawa Koichi , Yanagisawa Takafumi , Tashiro Kojiro , Tsuzuki Shunsuke , Koike Yusuke , Furuta Akira , Miki Jun , Kimura Takahiro 
Published: August 2023

Abstract

Background
Multiple studies have demonstrated the effectiveness of neoadjuvant chemotherapy and adjuvant chemotherapy in patients with upper tract urothelial carcinoma compared with surgery alone. However, no clinical trial has established the superiority of neoadjuvant chemotherapy or adjuvant chemotherapy in terms of perioperative outcomes.

Methods
We conducted a retrospective analysis encompassing 164 upper tract urothelial carcinoma patients who underwent radical nephroureterectomy and received perioperative chemotherapy. Of these patients, 65 (39.6%) and 99 (60.4%) received neoadjuvant chemotherapy and adjuvant chemotherapy, respectively. Recurrence-free survival and cancer-specific survival were computed using the Kaplan–Meier method. Additionally, we conducted Cox regression analyses to evaluate the risk factors for recurrence-free survival and cancer-specific survival.

Results
Pathological downstaging was seen in 37% of the neoadjuvant chemotherapy group. However, no pathological complete response was observed in this cohort. The Kaplan–Meier curves demonstrated significantly lower recurrence-free survival and cancer-specific survival in patients who received adjuvant chemotherapy. Multivariate Cox regression analysis revealed patients treated with adjuvant chemotherapy exhibited a marked association with inferior recurrence-free survival and cancer-specific survival.

Conclusion
Our study has suggested that neoadjuvant chemotherapy would be more effective in high-risk upper tract urothelial carcinoma patients compared with adjuvant chemotherapy.
Rights claims of citizen children of foreign national parents in South Africa, the UK, and the European Court of Human Rights: hierarchies of ‘illegality’ and deservingness
Authors: Sloth-Nielsen Julia , Collinson Jonathan , Spalding Amanda 
Published: August 2023

Abstract
This article examines the South African High Court judgement in TR & others v Minister of Home Affairs & others, which is the first time that a South African court has addressed the constitutional rights of children in the immigration context. In this case, constitutional rights claims were made by South African citizen children because South African immigration law deemed a foreign national parent to be an ‘illegal alien’, subject to expulsion, as soon their spousal relationship with a South African citizen had broken down. The law allowed no other outcome, other than expulsion, regardless of the impact on the affected children. We argue, therefore, that although the High Court deployed the language of children’s dignity and best interests, TR is not really a decision about children at all. Instead, it is a judgement about whether the parents’ deserved the status of ‘illegality’, and its consequences, which had been imposed by South African immigration law. This focus on the deservingness of the parents, rather than the best interests of the children, can be found in other jurisdictions and this article explores how the law deals with similar circumstances in the UK and the European Court of Human Rights. This article concludes by arguing that Article 3 CRC requires that ‘the sins and traumas of fathers and mothers should not be visited on their children’ and that this should be foundational to the best interests of the child provision in the South African constitution in the immigration context.
Associations with Prehospital Antibiotic Receipt among Combat Casualties with Open Wounds: A Department of Defense Trauma Registry Study
Authors: Karp Marissa C , April Michael D , Newberry Ryan K , Schauer Steven G 
Published: August 2023

ABSTRACT

Introduction
Current Tactical Combat Casualty Care (TCCC) guidelines recommend antibiotic administration for all open wounds to prevent infection. We identified associations between demographics, procedures, and medicines with the receipt of prehospital antibiotics among combat casualties.

Materials and Methods
We used a series of emergency department procedure codes to identify adult subjects within the Department of Defense Trauma Registry from January 2007 to August 2016 who sustained open wounds. We compared demographics, procedures, and medicines administered among casualties receiving prehospital wound prophylaxis versus casualties not receiving antibiotic prophylaxis. We controlled for confounders with multivariable logistical regression.

Results
We identified 18,366 encounters meeting inclusion criteria. Antibiotic recipients (n = 2384) were comparable to nonrecipients (n = 15,982) with regard to age and sex. Antibiotic recipients were more likely to sustain injuries from firearms and undergo all procedures examined related to hemorrhage control, airway management, pneumothorax treatment, and volume replacement except for intraosseous access. Antibiotic recipients were less likely to sustain injuries from explosives. Antibiotic recipients had a modestly higher survival than nonrecipients (97.4% versus 96.0%). Associations with prehospital antibiotic receipt in multivariable logistic regression included non-North Atlantic Treaty Organization military force affiliation (odds ratio (OR) 4.65, 95% CI, 1.0-20.8), tachycardia (OR 3.4, 95% CI, 1.1-10.5), intubation (OR 2.0, 95% CI, 1.1-3.8), and administration of tranexamic acid (OR 5.6, 95% CI, 1.2-26.5).

Conclusions
The proportion of combat casualties with open wounds receiving prehospital antibiotics was low despite published recommendations for early antibiotics in patients with open wounds. These findings highlight the ongoing need for additional educational and quality assurance initiatives to continue improving adherence to TCCC guidelines with regard to prehospital antibiotic administration. Future studies are necessary to determine reasons for suboptimal TCCC guideline compliance.
Antidepressants and survival in glioma—A registry-based retrospective cohort study
Authors: Edström Sonja , Hellquist Barbro Numan , Sandström Maria , Sadanandan Sajna Anand , Björkblom Benny , Melin Beatrice , Sjöberg Rickard L 
Published: August 2023

Abstract

Background
Depression and treatment with antidepressant medication is common in patients with malignant glioma. However, the extent to which antidepressants may affect the disease is not fully understood. Therefore, the purpose of the present study was to investigate possible associations between treatment with antidepressant medication and survival in glioma patients.

Methods
We performed a registry-based cohort study including 1231 patients with malignant glioma (WHO grades 2, 3, and 4) having undergone surgery, and 6400 matched controls without glioma. All data were extracted from the RISK North database, which contains information from multiple national population-based registries in Sweden.

Results
Treatment with antidepressants is more common in patients with malignant glioma (27%), compared to controls (16%), P &lt; .001. Treatment with antidepressants after surgery for glioma was significantly associated with poorer survival. These effects were observed both for selective serotonin reuptake inhibitors (SSRIs) and non-SSRIs. In grade 4 glioma, SSRI treatment was associated with a hazard ratio (HR) of 3.32 (95% CI 2.69–4.10, P &lt; .001), and non-SSRI treatment a HR of 3.54 (95% CI 2.52–4.99, P &lt; .001), compared to glioma patients without antidepressants. In grade 2-3 glioma, the HR for SSRI treatment was 3.26 (95% CI 2.19–4.85, P &lt; .001), and for non-SSRI treatment was 7.71 (95% CI 4.22–14.12, P &lt; .001).

Conclusions
Our results demonstrate a negative association between antidepressant medication and survival in glioma. Further research will be needed to clarify causation.