bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhalable SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization
Authors: Ye Tong , Jiao Zhouguang , Li Xin , He Zhanlong , Li Yanyan , Yang Fengmei , Zhao Xin , Wang Youchun , Huang Weijin , Qin Meng , Feng Yingmei , Qiu Yefeng , Yang Wenhui , Hu Lingfei , Hu Yaling , Zhai Yu , Wang Erqiang , Yu Di , Wang Shuang , Yue Hua , Wang Yishu , Wang Hengliang , Zhu Li , Ma Guanghui , Wei Wei 
Published: September 2023

Abstract
The coronavirus disease pandemic has fostered major advances in vaccination technologies; however, there are urgent needs for vaccines that induce mucosal immune responses and single-dose, noninvasive administration. Here, we develop an inhalable, single-dose, dry powder aerosol SARS-CoV-2 vaccine that induces potent systemic and mucosal immune responses. Our vaccine encapsulates proteinaceous cholera toxin B subunit-assembled nanoparticles displaying the SARS-CoV-2 RBD antigen within microcapsules of optimal aerodynamic size, and this unique nano-micro coupled structure supports efficient alveoli delivery, sustained antigen release, and antigen-presenting cell uptake, which are favourable features for induction of immune responses. Moreover, our vaccine successfully induces strong production of IgG and IgA, as well as a local T-cell response, collectively conferring effective protection against SARS-CoV-2 in mice, hamsters, and nonhuman primates. Finally, we also demonstrate a “mosaic iteration” of our vaccine that codisplays ancestral and Omicron antigens, extending the breadth of antibody response against cocirculating strains and transmission of the Omicron variant. These findings support our inhalable vaccine as a promising multivalent platform for fighting COVID-19 or other respiratory infectious diseases.
Dynamics of a three-phase polymer/fiber/CNT laminated nanocomposite conical shell with nonuniform thickness
Authors: Darakhsh Arashk , Rahmani Saeed , Amirabadi Hossein , Sarafraz Mirsalman , Afshari Hassan 
Published: September 2023

Abstract
In the presented paper, the free vibration of a polymer/fiber/CNT laminated nanocomposite conical shell with nonuniform thickness and surrounded by an elastic two-parameter foundation are analyzed. The shell is made of a polymeric matrix enriched simultaneously with randomly oriented carbon nanotubes (CNTs) and aligned glass fibers. CNTs agglomeration is included and the density and elastic constants of such a three-phase nanocomposite are calculated using the rule of mixture and the Eshelby–Mori–Tanaka approach alongside Hanh’s homogenization method. The conical shell and the elastic foundation are modeled using the first-order shear deformation theory (FSDT) and the Pasternak foundation model, consecutively. The governing equations are derived using Hamilton’s principle and are solved numerically via the differential quadrature method (DQM). The impacts of several parameters on the natural frequencies of such a structure are discussed such as thickness variation parameters, mass fraction and chirality of the CNTs, mass fraction of the fibers, and boundary conditions. It is observed that by considering the specific value for the average thickness of the shell, the thickness variation parameters associated with the highest natural frequency are different in various vibrational modes. It is discovered that, the natural frequencies grow by increasing mass fraction of the CNTs, but the influences of mass fraction of the fibers on the natural frequencies are strongly dependent on the vibration mode.
Exosomal miR-200c and miR-141 as cerebrospinal fluid biopsy biomarkers for the response to chemotherapy in primary central nervous system lymphoma
Authors: Hu Yao , Zhang Qingyun , Wu Zhiyuan , Chen Kun , Xu Xiao , Ma Weizhe , Chen Bobin , Jin Limin , Guan Ming 
Published: September 2023

Abstract
Background
To improve early diagnosis and chemotherapy efficacy monitoring in primary central nervous system lymphoma (PCNSL), cerebrospinal fluid (CSF) exosomal microRNA (miRNA) studies were performed.
Method
Small RNA sequencing was performed to identify candidate exosomal miRNAs as CSF biopsy biomarkers from two patients with de novo PCNSL and two patients in remission after chemotherapy. miR-200c and miR-141 expression in CSF exosomes was further validated using relative quantitative real-time polymerase chain reaction in patients with PCNSL (n = 20), patients with other neurological diseases (n = 10), and normal subjects (n = 10). Receiver operating characteristic (ROC) curve analyses of miR-200c and miR-141 in the diagnosis and prediction of chemotherapy efficacy in PCNSL were performed in patients treated with methotrexate. Additionally, bioinformatics tools were utilized to predict the potential targets of miR-200c and miR-141.
Results
Exosomal miR-200c and miR-141 levels in CSF from patients with PCNSL were significantly lower than those in control subjects. Importantly, miR-200c and miR-141 were upregulated in patients with PCNSL after chemotherapy (P = 0.002). There was a significant correlation between the levels of miR-141 and IL-10 in CSF (P = 0.04). The combination of miR-200c and miR-141 yielded an area under the ROC curve of 0.761 for distinguishing PCNSL with sensitivity and specificity of 60.0% and 96.7%, respectively. The potential target genes of miR-200c and miR-141 in PCNSL included ATP1B3, DYNC1H1, MATR3, NUCKS1, ZNF638, NUDT4, RCN2, GNPDA1, ZBTB38, and DOLK.
Conclusion
Collectively, miR-200c and miR-141 are likely to be upregulated in CSF exosomes after chemotherapy in patients with PCNSL, highlighting their potential as reliable liquid biopsy biomarkers for PCNSL diagnosis and chemotherapy efficacy monitoring.
A Phase 2 Evaluation of a New Flavored Peg and Sulfate Solution Compared to an Over-the-counter Laxative, Peg and Sports Drink Bowel Preparation Combination
Authors: Wiener Gregory , Winkle Peter , McGowan John D. , Cleveland Mark vB. , Palma Jack A. Di 
Published: September 2023

Abstract
Background:
Acceptability and tolerance of bowel preparation is critical to overcome patient hesitancy in undergoing colon cancer screening and surveillance colonoscopy. To improve patient experience, a new sports drink-flavored bowel preparation containing polyethylene glycol (PEG) and sulfate salts (FPSS) was developed to provide a similar experience to a commonly used but not unapproved PEG and sports drink bowel preparation (PEG-SD), while also achieving improved cleansing efficacy.
Methods:
This FPSS preparation, approved by the United States Food and Drug Administration in June 2023, was evaluated in a non-randomized Phase 2 study in which 40 patients requiring colonoscopy were prepared with FPSS and 20 with PEG-SD.
Results:
Overall cleansing success was high with FPSS based on unblinded local endoscopist assessment (93%) and blinded central reading (97%), exceeding PEG-SD which achieved success rates of 84% (local read), 74% and 68% (blinded central reads). Similar differences favoring FPSS were seen for excellent preparations and cleansing success by colon segment as rated by local endoscopists. Both preparations were well-tolerated, with 93% of FPSS patients rating their preparation as Tolerable to Very Easy to consume, compared to 100% of PEG-SD. Patients who had previously taken a preparation for colonoscopy found FPSS and PEG-SD better than their prior preparation (73% and 70%, respectively) and nearly all would request their assigned study preparation again in the future. About two thirds of FPSS patients agreed that the preparation tasted similar to a sports drink.
Conclusion:
The new sports drink-like flavored preparation compares favorably to PEG-SD for bowel cleansing efficacy while achieving similar patient satisfaction. The study was registered at www.clinicaltrials.gov (NCT03328507).
Feature Selection Algorithm Based on CFS Algorithm Emphasizing Data Discrimination
Authors: Liu Zhuo , Wang Chensheng , Li Ge 
Published: September 2023

Abstract
In the training of the neural network model, the large number of features in the data set will lead to the complexity of the network model and high time cost. Therefore, the feature selection operation of the original data set is carried out to select the feature subset conducive to model training to improve the model's performance. The traditional feature selection algorithm has the problems of a thin process and needs help to eliminate the features with small discrimination. Therefore, this paper proposes the discrimination filtering formula and DI-CFS feature selection algorithm. The discrimination filtering formula can filter out invalid features and inefficient features with small discrimination. DI-CFS algorithm combines discrimination filtering formula, isolation forest algorithm, and improved CFS algorithm. On a set of wind turbine data, the DI-CFS algorithm and other traditional feature selection algorithms are used to select features from the data, respectively, and the obtained feature subsets are input into the same neural network model for training and performing classification tasks. The experimental results show that the discrimination filtering formula has a positive effect, and the DI-CFS algorithm has a better feature selection effect.
Haplotype diversity of Heterodera koreana (Tylenchida: Heteroderidae), affecting bamboo in Korea
Authors: Kang Heonil , Ko Hyoung-Rai , Lim Yeon-Jeong , Park Eun-Hyeong , Kim Eun-Hwa , Park Se-Keun , Park Byeong-Yong , Han Hyerim 
Published: September 2023

Abstract
In a survey of plant-parasitic nematodes in agricultural fields, cyst-forming nematodes were found in soil planted bamboo in Korea. The aim of this study was to identify the cyst nematodes based on morphological and molecular characteristics. As the results, the morphology and morphometrics of cysts and second-stage juveniles (J2s) were consistent with those of previous descriptions of Heterodera koreana. In phylogenetic analyses based on DNA sequences, these cyst nematodes were clustered together with clade of H. koreana in internal transcribed spacer (ITS) region, and large subunit D2-D3 segments (LSU D2-D3). These nematodes were clustered together with clade of H. koreana in cytochrome c oxidase subunit I (COI) gene, but a haplotype was different when compared with previous reported haplotypes (haplotype A-C) in Japan. This study showed these cyst nematodes were identified as H. koreana, and a new haplotype of H. koreana is distributed in Korea. We suggest that the new haplotype of H. koreana name as haplotype D.
Running a Super SDM (Species Distribution Model) ‘in the cloud’ for Better Habitat- Associations, Predictions and Inference: Applying Open Access Big Data, Machine Learning Ensembles on Great Gray Owls in Alaska
Authors: Huettmann Falk , Andrews Phillip , Steiner Moriz , Das Arghya Kusum , Philip Jacques , Chunrong Mi , Bryans Nathaniel , Barker Bryan 
Published: September 2023

Abstract
The currently available distribution range maps for the Great Grey Owl (GGOW; Strix nebulosa) are rather coarse, imprecise, outdated, often hand-drawn and thus not quantified or scientific even. In this study, we present a proof of concept with a biological application for technical and biological workflow progress on latest global open access Big Data sharing, Open-source methods of R and geographic information systems (OGIS and QGIS) assessed with recent citizen-science sightings of the GGOW. This proposed workflow can be applied on the inference for species-habitat models such as typically applied with species distribution models (SDMs). Using Random Forest – an ensemble-type model of Machine Learning following Leo Breiman’s approach of inference from predictions - we present a Super SDM for Great Gray Owls in Alaska running on Oracle Cloud Infrastructure (OCI). These Super SDMs were based on best-publicly data (410 occurrences + 1% new assessment sightings) and over 100 environmental GIS habitat predictors. The compiled global open access data and the associated workflow achieve for the first time to overcome limitations for traditionally used PC and laptops (technological computing limitations), breaking new ground and have real-world implications for conservation and land management for GGOW, Alaska, and other species worldwide as a ‘new’ baseline. As this research field remains dynamic, SuperSDMs are not the ultimate and final statement on species-habitat associations yet, but they summarize all publicly available data and information on a topic allowing fine-tuning and improvements as needed. At minimum, it’s a great leap forward to be more ecological and inclusive. Using GGOWs, here we aim to correct the perception of this species towards a more inclusive, holistic, and scientifically correct assessment of this human-environment inhabiting owl in the Anthropocene, rather than a mysterious wilderness-inhabiting species (aka ‘Phantom of the North’). Such a Super SDM was never created for any bird species before and opens up new perspectives for impact assessment policy and global sustainability.
Assessment of the alpha 7 nicotinic acetylcholine receptor as an imaging marker of cardiac repair-associated processes using NS14490
Authors: Reid Victoria JM , McLoughlin Wesley KX , Stott Holly , Iškauskienė Monika , Sackus Algirdas , Marti Judit A , Kurian Dominic , Wishart Thomas M , Lucatelli Christophe , Peters Dan , Gray Gillian A , Baker Andrew H , Newby David E , Hadoke Patrick WF , Tavares Adriana AS , MacAskill Mark G 
Published: September 2023

Abstract
Background
Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Non-invasive imaging using a radiotracer targeting these processes could provide a key research tool to understand the underlying mechanisms in cardiac wound healing. Activation of the alpha7 nicotinic acetylcholine receptor (ɑ7nAChR) stimulates pro-reparative macrophage activity and angiogenesis. We investigated whether this target could serve as an imaging biomarker for these interlinked wound healing responses by assessing in vitro cellular expression and by using a tritiated-version of the PET radiotracer [18F]NS14490 in tissue autoradiography studies.
Results
ɑ7nAChR expression in monocyte-derived macrophages and vascular cells showed the highest relative expression was within macrophages, but only endothelial cells exhibited a proliferation and hypoxia driven increase in expression. Using a mouse model of inflammatory angiogenesis following sponge implantation, specific binding of [3H]NS14490 increased from 3.6 ± 0.2 µCi/g at day 3 post-implantation to 4.9 ± 0.2 µCi/g at day 7 (n = 4, p < 0.01), followed by a reduction in specific binding at days 14 and 21. This peak matched the onset of vessel formation and macrophage infiltration. In a rat MI model, specific binding of [3H]NS14490 was low within the myocardium of the sham cohort and the remote myocardium of the MI cohort. Specific binding within the infarcted myocardium increased from day 14 post-MI (33.8 ± 14.1 µCi/g, P ≤ 0.01 versus sham), peaking at day 28 (48.9 ± 5.1 µCi/g, P ≤ 0.0001 versus sham). Histological and proteomic profiling of ɑ7nAChR positive MI tissue revealed strong associations between the ɑ7nAChR signal and extracellular matrix deposition.
Conclusion
ɑ7nAChR is highly expressed in macrophages and showed proliferation and hypoxia driven expression in endothelial cells. While NS14490 imaging displays a pattern that coincides with vessel formation and macrophage infiltration in the sponge model, this is not the case in the MI model where the ɑ7nAChR signal strongly associated with extracellular matrix deposition. Overall, these findings support the involvement of ɑ7nAChR across several processes central to cardiac repair and warrant further investigation to assess the role of ɑ7nAChR in fibrosis and establish the relationship with cardiac function during adverse remodelling.
Impact of family support on the cognitive functions of Egyptian older population
Authors: Moustafa Sara , Gaballah Nada , Heikal Shimaa , Salama Mohamed 
Published: September 2023

Abstract
Background: Social support is essential in the daily activities of the older population, which can impact their cognitive functions over time.
Aim of the study: This study investigates the hypothesis that there is a link between social support and cognitive function in the older population living in the Egyptian community using the Arabic translation of the Survey of Health, Ageing, Retirement in Europe (SHARE) questionnaire.
Subjects and methods: Cross-sectional analytic study was conducted as a part of the pilot study for A Longitudinal Study of Egyptian Healthy Ageing (AL-SEHA) project. It included 299 participants (50+ years of age). Investigators collected data using the Arabic translation of the SHARE questionnaire in five Egyptian Universities. Data were then uploaded to the Social Research Centre (SRC) at the.
Results: The prevalence of declined cognitive functions was 39.467% (95% CI: 33.89-45.04). Cognitive impairment was significantly less among university and postgraduate degree holders (p<0.001), marital status (p=0.0378) or contact frequency by their children (p=0.0364).
Conclusion: Being married, with a university degree or higher, and increased contact frequency with children, all showed positive correlation with cognitive function in our sample. In conclusion, this research contributes to our understanding of the impact of family network and support and cognitive function in the older Egyptian population. Our findings can be a base to add on to the literature.
Diagnostic evaluation of institutions as a basis for designing the Brazilian maturity model of telehealth services.
Authors: Silva Angélica Baptista , Pisa Ivan Torres , Messina Luiz Ary , Pelogi Andréa Pereira Simões , Tenório Josceli Maria , Sousa Fernando Sequeira , Santos Daniela Lacerda , Maia Jessi , Filha Ianê Germano de Andrade , Guedes Ana Cristina Carneiro Menezes , Lopes Paulo Roberto de Lima , Maia Paulo Ricardo da Silva 
Published: September 2023

Abstract

Background
The number and specificities of telehealth service units that expanded their services and diversified with the COVID-19 pandemic in Brazil need to be discovered. The objective of this manuscript is to present a methodology for the diagnostic evaluation of 19 telehealth units from different regions of the country for federal governmental decision-making.
Methods
A cross-sectional quantitative and qualitative study was carried out in the form of a census based on administrative records with an online survey and in-depth interviews with local telehealth managers.
Results
Despite the discontinuity of regular funding, the results point to a diversity of initiatives and advances. Citizenship, sustainability, security, and budget management are recurring themes in the maturity analysis of telehealth services after the advent of the pandemic.
Conclusion
It is necessary for Brazil to build a resilient model of the maturity of telehealth services that contemplates the different regional scenarios.
Impact of ipsilateral false vocal fold resection on swallowing following transoral laser cordectomies - a pilot study
Authors: Burian Andras , Smatanova Katarina , Szanyi Istvan 
Published: September 2023

Abstract
Our aim was to investigate the early and late impact of false vocal fold removal (vestibulectomy) on swallowing using fibreoptic endoscopic evaluation of swallowing (FEES) following type III, IV and V transoral laser cordectomies (TLC). Fifteen endoscopically resectable glottic cancers necessitating TLC with vestibulectomy were included. FEES was performed preoperatively and in both the early and late postoperative periods establishing modified penetration aspiration scale (mPAS) and pharyngeal residue severity scale (PRSS). Laryngeal preservation and local recurrence were also noted. Due to 10 T1a, 2 T1b, 2 T2 and 1 selected T3 diseases, 2 type III, 9 type IV, 2 type Va and 2 type Vd cordectomies were performed. Early and late average postoperative PRSS scores were 1 and 0, respectively, while early and late postoperative mPAS scores were identically 1. Neither early nor late postoperative PRSS and mPAS values (0 and 1, respectively) differed remarkably from preoperative scores. Laryngeal preservation failed in only one case due to recurrence. TLC provides excellent laryngeal preservation in early glottic cancer. In our series, ipsilateral vestibulectomy during TLC did not deteriorate swallowing neither by increased pharyngeal residue nor by increased aspiration risk. Nevertheless, a higher case number is recommended to statistically confirm our observations.
Prevalence and clinical correlates of psychotic symptoms and its association with Internet addition symptoms in adolescents with major depressive disorder
Authors: Wang Song , Shi Yudong , Gu Jinyang , Gu Mengyue , Yang Yating , Li Mengdie , Zhang Ling , Zhang Yulong , Xia Lei , Liu Huanzhong , Geng Feng 
Published: September 2023

Abstract
Aim Psychotic symptoms in patients with major depressive disorder (MDD) have been associated with a worse clinical course, although previous studies reported substantial heterogeneity. Despite the relevance of the subject, the relationship between psychotic symptoms and socio-demographic and clinical characteristics of adolescent patients with MDD is not clear.Methods We screened 195 adolescents with MDD, and after excluding cases with changes in diagnosis or incomplete clinical data during the subsequent six months of follow-up, we included 161 cases to investigate the relationship between psychotic symptoms and clinical characteristics. According to the presentation of psychotic symptoms, patients were categorized into PD and NPD groups. Independent sample t-tests and chi-square tests were employed to compare these two groups. Binary logistic regression analysis was conducted to assess socio-demographic and clinical risk factors associated with psychotic symptoms.Results The prevalence of psychotic symptoms in these MDD adolescents was 27.3%. The scores of BMI, HAMD and IAT of MDD adolescents with psychotic symptoms were significantly higher than those of MDD adolescents without psychotic symptoms (both p < 0.05). A strong association was found between psychotic symptoms and suicide, with odds ratio of 4.012 for suicide.Conclusions These findings suggest that the psychotic symptoms of adolescents with MDD are closely related to Internet addiction and suicide attempts. It is crucial to address the occurrence of internet addiction symptoms when treating these patients, while also regularly assessing their suicidal attempts to effectively prevent self-harm.