bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stakeholder-driven development and implementation of CRICIT: an app to support high-quality data capture and protocol monitoring for outpatient clinical trials with vulnerable populations
Authors: Clark Katie , Ruth Caleb , Thomas Kathryn A. , Dunham Katherine , Travis Madelene , Rivera-Santiago Kristian , Brinkely-Rubinstein Lauren , Wang Emily 
Published: August 2023

Abstract

Introduction:
Choosing an appropriate electronic data capture system (EDC) is a critical decision for all randomized controlled trials (RCT). In this paper, we document our process for developing and implementing an EDC for a multisite RCT evaluating the efficacy and implementation of an enhanced primary care model for individuals with opioid use disorder who are returning to the community from incarceration.

Methods:
Informed by the Knowledge-to-Action conceptual framework and user-centered design principles, we used Claris Filemaker software to design and implement CRICIT, a novel EDC that could meet the varied needs of the many stakeholders involved in our study.

Results:
CRICIT was deployed in May 2021 and has been continuously iterated and adapted since. CRICIT’s features include extensive participant tracking capabilities, site-specific adaptability, integrated randomization protocols, and the ability to generate both site-specific and study-wide summary reports.

Conclusions:
CRICIT is highly customizable, adaptable, and secure. Its implementation has enhanced the quality of the study’s data, increased fidelity to a complicated research protocol, and reduced research staff’s administrative burden. CRICIT and similar systems have the potential to streamline research activities and contribute to the efficient collection and utilization of clinical research data.
Should You Put an Emoticon on Your Flag? How Subliminal Visual Stimuli Can Change Political Opinions
Authors: Sánchez Medero Rubén , Losada Maestre Roberto 
Published: August 2023

AbstractPolitical objects, like national flags, arouse emotions even when they are subliminal stimuli. Through two experiments that show subliminal stimuli to the subjects, this article analyzes if those emotions are positive or negative ones—that is to say, if they enhance an inclusive reaction or an excluding one. Besides, the article compares the intensity of the flag’s emotional effect with that of the emoticons, which are figures intended to represent emotional reactions or states. Findings confirm that the Spanish flag, as a subliminal stimulus, influences the opinions of the participants. However, it has had a lower effect than that obtained in previous, similar experiments. Emoticons produce a much more intense type of response than flags. The experiments (n = 85; n = 126) enlarge the knowledge about the emotional effects of political objects of nonconscious perception. Besides, we present an original methodological contribution: the use of emoticons to alter political views.
Sámi agency in economic development processes in the Norwegian High North
Authors: Angell Elisabeth , Eikeland Sveinung , Selle Per 
Published: August 2023

AbstractThe emergence of the Sámi Parliament has lifted Norwegian Sámi politics into an international discourse on indigenous peoples. The clearest imprints of the new Sámi political space are found in the High North region of Norway, where the Sámi account for a significant proportion of the population. The article shows to what extent and how Sámi agency affects governance structures and business development in the north in an increasingly globalised economic setting. From its origin, Sámi agency has influenced development in the High North through three processes: the first is through the Sámi institution building and strengthening of Sámi communities; the second is through its links to local and regional societal development; and the third is through the role of Sámi politics in globalised development processes. One main finding is that the boundaries between these links to the surrounding environment have become more diffuse. Sámi agency is taking a more important role in the economic development processes in the High North, often in terms of the local and regional processes, and now also within the increasingly important globalised economic modernisation processes in which inclusion in new multi-level governance structures is important.
Post-traumatic stress disorder symptom remission and cognition in a large cohort of civilian women
Authors: Liu Jiaxuan , Roberts Andrea L. , Lawn Rebecca B. , Jha Shaili C. , Sampson Laura , Sumner Jennifer A. , Kang Jae H. , Rimm Eric B. , Grodstein Francine , Liang Liming , Haneuse Sebastien , Kubzansky Laura D. , Koenen Karestan C. , Chibnik Lori B. 
Published: August 2023

AbstractBackgroundPost-traumatic stress disorder (PTSD) is associated with cognitive impairments. It is unclear whether problems persist after PTSD symptoms remit.MethodsData came from 12 270 trauma-exposed women in the Nurses' Health Study II. Trauma and PTSD symptoms were assessed using validated scales to determine PTSD status as of 2008 (trauma/no PTSD, remitted PTSD, unresolved PTSD) and symptom severity (lifetime and past-month). Starting in 2014, cognitive function was assessed using the Cogstate Brief Battery every 6 or 12 months for up to 24 months. PTSD associations with baseline cognition and longitudinal cognitive changes were estimated by covariate-adjusted linear regression and linear mixed-effects models, respectively.ResultsCompared to women with trauma/no PTSD, women with remitted PTSD symptoms had a similar cognitive function at baseline, while women with unresolved PTSD symptoms had worse psychomotor speed/attention and learning/working memory. In women with unresolved PTSD symptoms, past-month PTSD symptom severity was inversely associated with baseline cognition. Over follow-up, both women with remitted and unresolved PTSD symptoms in 2008, especially those with high levels of symptoms, had a faster decline in learning/working memory than women with trauma/no PTSD. In women with remitted PTSD symptoms, higher lifetime PTSD symptom severity was associated with a faster decline in learning/working memory. Results were robust to the adjustment for sociodemographic, biobehavioral, and health factors and were partially attenuated when adjusted for depression.ConclusionUnresolved but not remitted PTSD was associated with worse cognitive function assessed six years later. Accelerated cognitive decline was observed among women with either unresolved or remitted PTSD symptoms.
The Hobbesian Crowd Problem
Authors: Foisneau Luc 
Published: August 2023

AbstractIn this article I try to identify the nature of the Hobbesian Crowd Problem as a problem depending on the nature of the connection, or absence of connection, between the notions of “crowd” and “people.” When a crowd is considered as a “subjected crowd” it is but the flip side of a people, which is itself the other name of the sovereign. When considered as a gathering of people, the crowd's status depends on the intention of its members as well as the number of its participants, but also on whether it is authorized by the sovereign. Within the framework of his complex theory of associations (or “system subjects”), Hobbes's theory of crowds is a useful instrument for assessing what we now call “populism,” the claim by some citizens to speak for the whole political community.
Herder on the Self-Determination of Peoples
Authors: Piirimäe Eva 
Published: August 2023

AbstractRecent studies have argued that Herder supported cultural, rather than national, self-determination. While Herder did not argue that all nations should become states, using the term “cultural” as the defining element of his conception of self-determination risks the false impression that political self-determination is not part of it. Focusing on Herder's discussion of the relationship between the people and the state in modern European “state-machines” and his comments on the French revolution, this article shows that Herder encouraged the national “self-constitution” of both subjugated and dominant peoples, thus contributing to the rise of the concept of self-determination of peoples. Rejecting direct popular rule as a “phantom of liberty,” he envisioned modern self-determination to be a continuous process of free public deliberation in print media and representative institutions on the possible reform of the constitution of one's political community, as guided by the public's evolving understanding of the principles of Humanität.
Synchronization control of blanket remote maintenance robot based on MPC-CCC algorithm
Authors: Li Dongyi , Lu Kun , Cheng Yong , Wu Huapeng , Handroos Heikki , Zhang Xuanchen , Guo Xinpeng , Yang Songzhu , Du Liansheng , Zhang Yu 
Published: August 2023

AbstractThis paper studies the synchronization control of the blanket remote maintenance robot (BRMR) of the China fusion engineering test reactor (CFETR). First, the general state space mathematical model of BRMR was established by using a physical-based method. Second, based on the receding horizon optimization of model predictive control (MPC) and cross-coupling error reduction in cross-coupling control (CCC), the innovative MPC-CCC controller was proposed to realize the single-system and multisystem error convergence and high accuracy transportation of blanket through the high accuracy synchronization control of BRMR. Third, to verify the control effectiveness of the MPC-CCC controller, two types of simulations and experiments were implied compared with the original proportional-integral (PI) controller in Mover. Results showed that simulation and experiments were highly consistent. It is found that the use of an MPC-CCC controller can result in up to a 70% reduction in displacement error and up to a 59% reduction in synchronization error compared to the PI controller. And the accuracy of the MPC-CCC controller satisfies the real requirement of the maintenance process of the blanket. This work provides the theoretical basis and practical experience for the highly stable, safe, and efficient maintenance of blankets in the future.
Estimation of vaccination coverage and associated factors in older Mexican adults
Authors: García-Hernández Héctor , Zárate-Ramírez Judith , Kammar-García Ashuin , García-Peña Carmen 
Published: August 2023

AbstractNational vaccination programmes recommend the influenza vaccine for older adults, but this population group has the greatest morbidity and mortality from other preventable vaccine diseases. The aim of this article is to estimate the vaccine coverage in adults aged 65 years and older and to analyse the factors that could increase or decrease vaccination uptake probability for the three listed vaccines in the national vaccination programme (influenza, tetanus and diphtheria, and pneumococcus) and the full scheme in Mexico. We conducted an analytical cross-sectional study with 2012, 2018, and 2021 rounds from the National Health and Nutrition Survey, in which we calculated the vaccine coverage estimations and performed multivariable logistic regression models to analyse the factors related to vaccine uptake. Tetanus and diphtheria vaccines had the greatest coverage estimation in all years (59–71%), whereas the pneumococcus vaccine had the lowest (32–53%). Full scheme vaccine coverage decreased from 37.80% to 24.77% in 2012 and 2021, respectively. The National Health Card property, morbidity, being a beneficiary of any health system institution, and use of preventive services increased the probability of vaccine uptake. In conclusion, vaccine coverage in older Mexican adults decreased over time, and the Mexican health system plays a strategic role in immunisation.
Ten years of German benefit assessment: price analysis for drugs with unproven additional benefit
Authors: Kleining Katrin , Laufenberg Jan , Thrun Philip , Ehlert Dorothee , Wasem Jürgen , Bartol Arne 
Published: August 2023

AbstractIntroductionSince 2011, the prices for all new drugs in Germany are negotiated based on a benefit assessment. The purpose of this study was to analyze the price regulation of drugs with unproven additional benefit.MethodsBenefit assessment procedures from 2011 to 2020 were reviewed and selected through AMNOG Monitor and Lauer Taxe. Negotiated annual therapy costs, the annual costs of the most cost-efficient appropriate comparative therapy (ACT) and the potential budget impact for 33 included procedures were calculated.Results55% of the included drugs achieved a negotiated price higher than the most cost-efficient ACT, 3% were identified as equal and 42% showed lower negotiated prices. The potential savings exceeded expenditures by around EUR 523.5 m. After price flexibility was adopted by the legislator in 2017, the overall potential savings still outweighed the expenditures by around EUR 62 m.ConclusionsOur analysis shows that making price negotiations more flexible by law does not undermine the fundamental aim of the AMNOG, which is to avoid additional expenditure without increased patient benefit. The regulation can thus fulfill the objective provided by the legislature of keeping drugs without proven additional benefits in the German healthcare system.
The Taverna San Felice Dike (NE of Roccamonfina Volcano): Unraveling Magmatic Intrusion Processes and Volcano‐Tectonics in the Tyrrhenian Margin of the Southern Apennines
Authors: Natale Jacopo , Vitale Stefano , Giordano Guido , Fedele Lorenzo , Lucci Federico , Vona Alessandro , Prinzi Ernesto Paolo , Tramparulo Francesco D’Assisi , Isaia Roberto , Ciarcia Sabatino 
Published: August 2023

AbstractThe Roccamonfina volcano is located within the Garigliano Graben (southern Apennines, Italy) and has been active throughout the Middle‐Late Pleistocene. Along its polyphase volcanic history (630–55 ka), including several caldera‐forming eruptions (385–230 ka), several effusive/mildly explosive monogenetic events occurred along the volcano slopes, within the summit caldera, and along the graben‐bounding carbonate reliefs. In this paper, we present a multidisciplinary study of a mafic magmatic feeder dike intruded within the Meso‐Tertiary carbonates and overlying Lower Pleistocene breccias of Mt Cesima, northeast of the Roccamonfina volcano. We performed a stratigraphic and structural survey of the area and petrographic analyses on several samples of the dike. Results indicate that a ∼1 km long fissure fed an eruption that also emplaced a Strombolian pyroclastic sequence. Petrological data show that an open‐system mafic recharge fueled the tephritic magma that fed the eruption, whereas no evidence of significant pre/syn‐eruptive assimilation of carbonate has been identified. Stratigraphic and petrological data do not allow to firmly constrain the timing of the eruption, which could belong both to the pre‐Brown Leucitic Tuff (>354 ka) and to the post‐White Trachytic Tuffs (<230 ka) epochs of activity of the Roccamonfina volcano. Structural data show that the dike is broadly oriented E‐W and changes direction toward NE‐SW in correspondence with a pre‐existing fault damage zone. We suggest that magma was intruded during an N‐S trending extensional event in the Middle Pleistocene, whose prolonged activity resulted in regional uplift and exhumation of regional significance.
Towards a youth mental health paradigm: a perspective and roadmap
Authors: Uhlhaas Peter J. , Davey Christopher G. , Mehta Urvakhsh Meherwan , Shah Jai , Torous John , Allen Nicholas B. , Avenevoli Shelli , Bella-Awusah Tolulope , Chanen Andrew , Chen Eric Y. H. , Correll Christoph U. , Do Kim Q. , Fisher Helen L. , Frangou Sophia , Hickie Ian B. , Keshavan Matcheri S. , Konrad Kerstin , Lee Francis S. , Liu Cindy H. , Luna Beatriz , McGorry Patrick D. , Meyer-Lindenberg Andreas , Nordentoft Merete , Öngür Dost , Patton George C. , Paus Tomáš , Reininghaus Ulrich , Sawa Akira , Schoenbaum Michael , Schumann Gunter , Srihari Vinod H. , Susser Ezra , Verma Swapna K. , Woo T. Wilson , Yang Lawrence H. , Yung Alison R. , Wood Stephen J. 
Published: August 2023

AbstractMost mental disorders have a typical onset between 12 and 25 years of age, highlighting the importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health. This perspective addresses interactions between risk and protective factors and brain development as key pillars accounting for the emergence of psychopathology in youth. Moreover, we propose that novel approaches towards early diagnosis and interventions are required that reflect the evolution of emerging psychopathology, the importance of novel service models, and knowledge exchange between science and practitioners. Taken together, we propose a transformative early intervention paradigm for research and clinical care that could significantly enhance mental health in young people and initiate a shift towards the prevention of severe mental disorders.
Cerebellar deep brain stimulation for chronic post-stroke motor rehabilitation: a phase I trial
Authors: Baker Kenneth B. , Plow Ela B. , Nagel Sean , Rosenfeldt Anson B. , Gopalakrishnan Raghavan , Clark Cynthia , Wyant Alexandria , Schroedel Madeleine , Ozinga John , Davidson Sara , Hogue Olivia , Floden Darlene , Chen Jacqueline , Ford Paul J. , Sankary Lauren , Huang Xuemei , Cunningham David A. , DiFilippo Frank P. , Hu Bo , Jones Stephen E. , Bethoux Francois , Wolf Steven L. , Chae John , Machado André G. 
Published: August 2023

AbstractUpper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts. In this open-label, non-randomized phase I trial, we applied deep brain stimulation to the cerebellar dentate nucleus combined with renewed physical rehabilitation to promote functional reorganization of ipsilesional cortex in 12 individuals with persistent (1–3 years), moderate-to-severe upper-extremity impairment. No serious perioperative or stimulation-related adverse events were encountered, with participants demonstrating a seven-point median improvement on the Upper-Extremity Fugl-Meyer Assessment. All individuals who enrolled with partial preservation of distal motor function exceeded minimal clinically important difference regardless of time since stroke, with a median improvement of 15 Upper-Extremity Fugl-Meyer Assessment points. These robust functional gains were directly correlated with cortical reorganization evidenced by increased ipsilesional metabolism. Our findings support the safety and feasibility of deep brain stimulation to the cerebellar dentate nucleus as a promising tool for modulation of late-stage neuroplasticity for functional recovery and the need for larger clinical trials. ClinicalTrials.gov registration: NCT02835443.
Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders
Authors: Segal Ashlea , Parkes Linden , Aquino Kevin , Kia Seyed Mostafa , Wolfers Thomas , Franke Barbara , Hoogman Martine , Beckmann Christian F. , Westlye Lars T. , Andreassen Ole A. , Zalesky Andrew , Harrison Ben J. , Davey Christopher G. , Soriano-Mas Carles , Cardoner Narcís , Tiego Jeggan , Yücel Murat , Braganza Leah , Suo Chao , Berk Michael , Cotton Sue , Bellgrove Mark A. , Marquand Andre F. , Fornito Alex 
Published: August 2023

AbstractThe substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case–control research, which relies on group mean comparisons. Here we present a comprehensive, multiscale characterization of the heterogeneity of gray matter volume (GMV) differences in 1,294 cases diagnosed with one of six conditions (attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, depression, obsessive–compulsive disorder and schizophrenia) and 1,465 matched controls. Normative models indicated that person-specific deviations from population expectations for regional GMV were highly heterogeneous, affecting the same area in <7% of people with the same diagnosis. However, these deviations were embedded within common functional circuits and networks in up to 56% of cases. The salience–ventral attention system was implicated transdiagnostically, with other systems selectively involved in depression, bipolar disorder, schizophrenia and attention-deficit/hyperactivity disorder. Phenotypic differences between cases assigned the same diagnosis may thus arise from the heterogeneous localization of specific regional deviations, whereas phenotypic similarities may be attributable to the dysfunction of common functional circuits and networks.
Time-varying overdispersion of SARS-CoV-2 transmission during the periods when different variants of concern were circulating in Japan
Authors: Ko Yura K. , Furuse Yuki , Otani Kanako , Yamauchi Masato , Ninomiya Kota , Saito Mayuko , Imamura Takeaki , Cook Alex R. , Ahiko Tadayuki , Fujii Shunji , Mori Yoshiharu , Suzuki Emiko , Yamada Keiko , Ashino Yoshikazu , Yamashita Hidetoshi , Kato Yuichi , Mizuta Katsumi , Suzuki Motoi , Oshitani Hitoshi 
Published: August 2023

AbstractJapan has implemented a cluster-based approach for coronavirus disease 2019 (COVID-19) from the pandemic’s beginning based on the transmission heterogeneity (overdispersion) of severe acute respiratory coronavirus 2 (SARS-CoV-2). However, studies analyzing overdispersion of transmission among new variants of concerns (VOCs), especially for Omicron, were limited. Thus, we aimed to clarify how the transmission heterogeneity has changed with the emergence of VOCs (Alpha, Delta, and Omicron) using detailed contact tracing data in Yamagata Prefecture, Japan. We estimated the time-varying dispersion parameter ($${k}_{t}$$

k
t

) by fitting a negative binomial distribution for each transmission generation. Our results showed that even after the emergence of VOCs, there was transmission heterogeneity of SARS-CoV-2, with changes in $${k}_{t}$$

k
t

during each wave. Continuous monitoring of transmission dynamics is vital for implementing appropriate measures. However, a feasible and sustainable epidemiological analysis system should be established to make this possible.
N-glycosylation in non-invasive and invasive intraductal papillary mucinous neoplasm
Authors: Nieminen Heini , Nummela Pirjo , Satomaa Tero , Heiskanen Annamari , Hiltunen Jukka O. , Kaprio Tuomas , Seppänen Hanna , Hagström Jaana , Mustonen Harri , Ristimäki Ari , Haglund Caj 
Published: August 2023

AbstractIntraductal papillary mucinous neoplasms (IPMNs), often found incidentally, are potentially malignant cystic tumors of the pancreas. Due to the precancerous nature, IPMNs lacking malignant features should be kept on surveillance. The follow-up relies on magnetic resonance imaging, which has a limited accuracy to define the high-risk patients. New diagnostic methods are thus needed to recognize IPMNs with malignant potential. Here, aberrantly expressed glycans constitute a promising new area of research. We compared the N-glycan profiles of non-invasive IPMN tissues (n = 10) and invasive IPMN tissues (n = 10) to those of non-neoplastic pancreatic controls (n = 5) by matrix-assisted laser desorption-ionization time-of-flight (MALDI-TOF) mass spectrometry. Both IPMN subgroups showed increased abundance of neutral composition H4N4 and decrease in H3N5F1, increase in sialylation, and decrease in sulfation, as compared to the controls. Furthermore, invasive IPMN showed an increase in terminal N-acetylhexosamine containing structure H4N5, and increase in acidic complex-type glycans, but decrease in their complex fucosylation and sulfation, as compared to the controls. In conclusion, the N-glycan profiles differed between healthy pancreatic tissue and non-invasive and invasive IPMNs. The unique glycans expressed in invasive IPMNs may offer interesting new options for diagnostics.