bluuebunny/crossref_metadata_2025_split huggingface dataset:
The practice of waste management in the RUDN University
Authors: Savenkova Elena , Redina Margarita 
Published: July 2023

Abstract
The pandemic period has left a serious imprint on the development of universities: the formats and content of lectures, workshops, research directions and, in general, the organization of university life. However, the role of universities as centres for the development of a culture of sustainable development remains unchanged: development of new educational courses, demonstration of the university’s achievements in reducing the amount of waste generated, as well as interdisciplinary research on the climate neutrality of the waste management industry. The University implements educational activities for schoolchildren, students, and volunteers. Waste recycling programs have been implemented. A new direction of the university’s activity is the analysis of the carbon footprint of organizations within the framework of the work of the greenhouse gas validation and verification body, the first in Russia to be opened at the RUDN. Management of greenhouse gas flows in waste management is a very popular area of validation and verification. The involvement of university students in research programs involves the development of this topic. The University is a representative facility for estimating greenhouse gas flows caused by waste flows. Thus, the pandemic period has become a period of opportunities for RUDN to create a new scientific and educational direction.
Gambling among indebted individuals: an analysis of bank transaction data
Authors: Marionneau Virve K , Lahtinen Aino E , Nikkinen Janne T 
Published: July 2023

Abstract

Background
Gambling is connected to important financial harms, including debt. Most existing research has investigated the relationship between gambling and debt using self-reported data. Only a few studies have used objective data. The current study focuses on the gambling of indebted individuals. It investigates the amounts and types of gambling consumed by indebted individuals, and the amounts of unsecured debt among heavy gamblers.

Methods
We use past-year banking data of Finnish individuals (N = 23 231) collected between 2018 and 2021 among applicants to a debt consolidation service. The transactions consist of deposits to, and winnings paid by gambling operators, distinguished by type of gambling (sports betting, casino, lottery) as well as active loans divided into secured and unsecured loans.

Results
Gambling is widespread among indebted individuals in Finland. In terms of gambling types, casino-type gambling is the most popular among indebted individuals. Gambling spending is highly concentrated. Nearly half (49.5%) of all gambling deposits are concentrated among the highest spending 5% of indebted individuals. Individuals with unsecured loans have higher median losses than those without unsecured loans.

Conclusions
The results suggest that gambling and indebtedness are strongly linked. The connection is stronger for individuals with unsecured debt. This has implications for prevention and treatment. Easy access to unsecured credit is likely to worsen gambling harms. Debt counselling services routinely encounter gambling-related harms and need to be equipped to manage these issues.
Self-rated work ability as a risk factor for disability retirement
Authors: Kainulainen Sakari , Elovainio Marko , Laaksonen Mikko , Jääskeläinen Tuija , Rissanen Harri , Koskinen Seppo 
Published: July 2023

AbstractBackgroundSimple and efficient survey measures to predict staying in or leaving work are needed. We examined the association of single-item self-rated work ability (SRWA) with disability retirement in two large population-based samples and compared the association of SRWA to two other scales, work ability score (WAS) and self-rated health (SRH), used earlier in studies.MethodsThe study population comprised 6034 participants aged 35–58 from the population-based Health 2000 and FinHealth 2017 cohort studies, pooled together. SRWA, WAS and SRH were all classified in three categories: poor, limited and good. A 36-month follow-up for disability retirement via linkage to electronic records was included in the analysis.ResultsOf the participants, 195 retired during the follow-up. All three measures strongly predicted disability retirement. Hazard ratio (HR) for poor SRWA (vs. good) was 8.48 [95% confidence interval (CI) 5.41–13.28], WAS 7.99 (95% CI 5.62–11.37) and SRH 5.96 (95% CI 4.17–8.51). HR for limited SRWA (vs. good) was 4.35 (95% CI 3.21–5.91), WAS 3.54 (95% CI 2.49–5.04) and SRH 2.27 (95% CI 1.59–3.23). Taking into account gender, age, education and mental health narrowed the gap between poor and limited vs. good work ability as predictors of disability retirement, but the differences remained clear.ConclusionsLimited or poor self-rated work ability or health are strong predictors of disability retirement. The SRWA measure is a useful survey-measure of work ability in community-based surveys.
Opi1-mediated transcriptional modulation orchestrates genotoxic stress response in budding yeast
Authors: Panessa Giovanna Marques , Tassoni-Tsuchida Eduardo , Pires Marina Rodrigues , Felix Rodrigo Rodrigues , Jekabson Rafaella , de Souza-Pinto Nadja Cristhina , da Cunha Fernanda Marques , Brandman Onn , Cussiol José Renato Rosa 
Published: July 2023

Abstract
In budding yeast, the transcriptional repressor Opi1 regulates phospholipid biosynthesis by repressing expression of genes containing inositol-sensitive upstream activation sequences. Upon genotoxic stress, cells activate the DNA damage response to coordinate a complex network of signaling pathways aimed at preserving genomic integrity. Here, we reveal that Opi1 is important to modulate transcription in response to genotoxic stress. We find that cells lacking Opi1 exhibit hypersensitivity to genotoxins, along with a delayed G1-to-S-phase transition and decreased gamma-H2A levels. Transcriptome analysis using RNA sequencing reveals that Opi1 plays a central role in modulating essential biological processes during methyl methanesulfonate (MMS)–associated stress, including repression of phospholipid biosynthesis and transduction of mating signaling. Moreover, Opi1 induces sulfate assimilation and amino acid metabolic processes, such as arginine and histidine biosynthesis and glycine catabolism. Furthermore, we observe increased mitochondrial DNA instability in opi1Δ cells upon MMS treatment. Notably, we show that constitutive activation of the transcription factor Ino2-Ino4 is responsible for genotoxin sensitivity in Opi1-deficient cells, and the production of inositol pyrophosphates by Kcs1 counteracts Opi1 function specifically during MMS-induced stress. Overall, our findings highlight Opi1 as a critical sensor of genotoxic stress in budding yeast, orchestrating gene expression to facilitate appropriate stress responses.
What Becomes a Refugee Camp? Making Camps for European Refugees in North Africa and the Middle East, 1943–46
Authors: Mackinnon Katherine , White Benjamin Thomas 
Published: July 2023

AbstractRefugees have often been housed in camps made by ‘adaptive reuse’ of a wide range of existing sites. We argue that any given refugee camp’s previous uses shape the experiences of its residents and may indicate how that displaced population is viewed by the responsible authorities. We test this argument on three historical case studies drawn from an important but under-researched episode in the history of the refugee camp: the far-flung network of camps established by the Allies in North Africa and the Middle East in the 1940s for European refugees from Fascism. They range from a former hotel housing under 50 people to a vast tented encampment housing over 20,000, adapted from an army ‘rear camp’. We argue that research on any given camp should include analysis of the site’s architectural origins. This is a step towards a more fully articulated methodological approach to researching refugee camps, the ‘site biography’.
Evaluation of Culture Conducive to Academic Success by Gender at a Comprehensive Cancer Center
Authors: Keenan Bridget P , Sibley Amanda , Zhang Li , Westring Alyssa F , Velazquez Ana I , Bank Erin M , Bergsland Emily K , Boreta Lauren , Conroy Patricia , Daras Mariza , Hermiston Michelle , Hsu Gerald , Paris Pamela L , Piawah Sorbarikor , Sinha Sumi , Sosa Julie A , Tsang Mazie , Venook Alan P , Wong Melisa , Yom Sue S , Van Loon Katherine 
Published: July 2023

Abstract

Introduction
The primary objective of this study was to determine whether workplace culture in academic oncology differed by gender, during the COVID-19 pandemic.

Materials and Methods
We used the Culture Conducive to Women’s Academic Success (CCWAS), a validated survey tool, to investigate the academic climate at an NCI-designated Cancer Center. We adapted the CCWAS to be applicable to people of all genders. The full membership of the Cancer Center was surveyed (total faculty = 429). The questions in each of 4 CCWAS domains (equal access to opportunities, work-life balance, freedom from gender bias, and leadership support) were scored using a 5-point Likert scale. Median score and interquartile ranges for each domain were calculated.

Results
A total of 168 respondents (men = 58, women = 106, n = 4 not disclosed) submitted survey responses. The response rate was 39% overall and 70% among women faculty. We found significant differences in perceptions of workplace culture by gender, both in responses to individual questions and in the overall score in the following domains: equal access to opportunities, work-life balance, and leader support, and in the total score for the CCWAS.

Conclusions
Our survey is the first of its kind completed during the COVID-19 pandemic at an NCI-designated Cancer Center, in which myriad factors contributed to burnout and workplace challenges. These results point to specific issues that detract from the success of women pursuing careers in academic oncology. Identifying these issues can be used to design and implement solutions to improve workforce culture, mitigate gender bias, and retain faculty.
Active Living and the Politics of Implementation: A Review Article
Authors: Forsyth Ann 
Published: July 2023

Abstract
Drawing on five case studies, Lawrence D. Brown's Political Exercise: Active Living, Public Policy, and the Built Environment (2022) examines the complex path to fruition of comprehensive policy approaches. The health-promotion approach called active living, or modifying the built environment to encourage physical exercise in everyday life, experienced a peak of interest in parts of two decades. Looking at five very different places (Wilkes-Barre, Pennsylvania; Louisville, Kentucky; Albuquerque, New Mexico; Sacramento, California; and New York, New York), Brown explores how difficult it is to implement active living in practice. Brown argues that active living is perceived by many to be a good thing. However, few organizations or parts of government see it as their main focus. It requires substantial collaborative work, which is typically difficult. Implementing active living requires strategies beyond the typical public health toolkit, including those from urban planning. Brown introduces the term implementation sensitivity to explain policies that are susceptible to dissonance between policy aims and political realities. Obstacles faced by policy proponents include local particularities that make it hard to transfer or scale up solutions, intersectoral pluralism or multiple lines of authority, and the need for effective champions. The path from policy to implementation is not linear but iterative.
The Impact of Restricting Labor Mobility on Corporate Investment and Entrepreneurship
Authors: Jeffers Jessica S 
Published: July 2023

Abstract
This paper examines how labor mobility restrictions like noncompete agreements affect firms’ investment decisions. Using matched employee-employer data from LinkedIn, I show that increases in the enforceability of noncompete agreements lead to widespread declines in employee departures, specifically in knowledge-intensive occupations. Established firms that rely more on these knowledge-intensive occupations increase their investment rate in physical capital. However, new firm entry in corresponding sectors declines. I provide evidence for different mechanisms to explain these patterns. Together, the findings show that labor frictions play an important role in investment decisions.
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Newly uncovered biochemical and functional aspects of ferritin
Authors: Yanatori Izumi , Nishina Sohji , Kishi Fumio , Hino Keisuke 
Published: July 2023

AbstractIron homeostasis is strictly regulated at both the systemic and cellular levels by complex mechanisms because of its indispensability and toxicity. Among the various iron‐regulatory proteins, ferritin is the earliest discovered regulator of iron metabolism and is a molecule that safely retains excess intracellular iron in the cores of its shells. Two types of ferritin, cytosolic ferritin and mitochondrial ferritin (FTMT), have been identified in a range of organisms from plants to humans. FTMT was identified approximately 60 years after the discovery of cytosolic ferritin. Cytosolic ferritin expression is regulated in an iron‐responsive manner. Recently, the molecular mechanisms of iron‐dependent degradation of cytosolic ferritin or its secretion into serum have been clarified. FTMT, which shares a high degree of sequence homology with cytosolic ferritin, has distinct functions and is regulated in different ways from cytosolic ferritin. Although knowledge of the physiological role of FTMT is still incomplete, recent studies have shed light on the function and regulation of FTMT. The accumulating biological evidence of both ferritins has made it possible to deepen our knowledge about iron metabolism and its significance in diseases. In this review, we discuss the biological properties of both ferritins, focusing on their newly uncovered behaviors.
Laparoscopic treatment of complicated obturator hernia: A case series of 6 patients
Authors: Dang Thanh Nhu , Pham Vu Anh , Nguyen Tri Huu 
Published: July 2023

Abstract
Obturator hernia (OH) is a rare type of abdominal hernia. Preoperative diagnosis of OH is often challenging because of nonspecific signs and symptoms, leading to late diagnosis and increased mortality. Laparoscopic repair has been suggested as one of the alternative options for complicated inguinal hernias. We describe a case series of 6 consecutive patients diagnosed with complicated OH and treated by laparoscopic repair. All patients were females, aged 81 to 90 years. Most of them were underweight (body mass index, <18.5 kg/m2). All cases presented with acute small bowel obstruction. All cases were unilateral OH. Concomitant femoral hernia existed in 3 cases (50%). Bowel resection was required in 2 cases because of bowel ischemia and perforation. Four of 6 cases were repaired using synthetic mesh, and the 2 remaining patients were treated with peritoneal closure and medial umbilical fold flap reinforcement. There were no postoperative deaths. Laparoscopic repair seems to be a safe and effective option for the treatment of complicated OH.
Stress, Grit, Satisfaction With Life, and Remediation of Prelicensure Nursing Students
Authors: Tsusaki Rebecca , Mullassery Daisy , Ramaswamy Padmavathy 
Published: July 2023

Background:
Stress and poor academic performance often lead to high levels of nursing school attrition.

Purpose:
To explore nursing students' perceived stress, grit, and satisfaction with life, and assess the effectiveness of a remediation program for students at risk for poor academic performance.

Methods:
Perceived stress, grit, and satisfaction with life were measured, and the effect of remediation given to at-risk students was studied. Examination and psychometric scores were compared between remediation and nonremediation groups.

Results:
The remediation group had higher levels of perceived stress and a lower satisfaction with life compared with the rest of the cohort. Remediation significantly improved examination scores of at-risk students although scores remained lower than those among nonremediation students.

Conclusions:
Perceived stress and grit scores were high in nursing students, and satisfaction varied among age groups. Remediation based on metacognitive theory significantly improved at-risk students' examination scores.
Impact of Liver Transplantation on Adipose Tissue Compartments and Its Association With Metabolic Sequela
Authors: Hassouneh Ramzi , Flynn Sean , Shen Steve , Tseng Michael , Bui Anh Tuan , Pham Jay , Park Dan , Matherly Scott , Bruno David , Lee Seung , Kumaran Vinay , Patel Vaishali , Muthiah Mark , Sharma Amit , Siddiqui Mohammad Shadab 
Published: July 2023

Background.
Loss of skeletal muscle can be accompanied by an increase in adipose tissue leading to sarcopenic obesity. There are limited data on how liver transplantation (LT) might impact adipose tissue compartments, particularly among patients with metabolically active disease, such as nonalcoholic steatohepatitis (NASH) and subsequent metabolic sequela.

Methods.
Skeletal muscle, visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) were measured using cross-sectional imaging performed in 190 patients pre-LT, 6 mo post-LT and 12 mo post-LT. Changes in adipose tissue and their impact on metabolic diseases were determined in patients transplanted for NASH versus non-NASH.

Results.
Skeletal muscle, VAT, and SAT were similar in patients with NASH and non-NASH pre-LT despite a higher burden of metabolic diseases in patients with NASH. Following LT, no significant differences between skeletal muscle and SAT were observed in the entire cohort and among patients with NASH (versus non-NASH). LT recipients with the highest muscle mass pre-LT were at the greatest risk for muscle loss post-LT. A time-dependent increase in VAT was noted post-LT, which was more robust among patients with a history of NASH cirrhosis. In adjusted multivariate analysis, NASH versus non-NASH was a strong predictor of post-LT increase in VAT (β-coefficient 3.00, P = 0.04). Pre-LT VAT was an independent predictor of post-LT serum triglycerides (β-coefficient 5.49 ± 2.78, P = 0.05) and low-density lipoprotein cholesterol (β-coefficient 1.80 ± 0.75, P = 0.02). A trend between pre-LT VAT and diabetes was noted but did not reach statistical significance.

Conclusions.
VAT but not SAT increases rapidly after LT, especially among patients transplanted for NASH cirrhosis and predicts future metabolic burden.
Web-based eye-tracking for remote cognitive assessments: The anti-saccade task as a case study
Authors: Juantorena Gustavo E , Figari Francisco , Petroni Agustín , Kamienkowski Juan E 
Published: July 2023

AbstractOver the last years, several developments of remote webcam-based eye tracking (ET) prototypes have emerged, testing their feasibility and potential for web-based experiments. This growing interest is mainly explained by the possibility to perform tasks remotely, which allows the study of larger and hard-to-reach populations and potential applications in telemedicine. Nevertheless, a decrease in the quality of the camera and a noisier environment bring new implementation challenges. In this study, we present a new prototype of remote webcam-based ET. First, we introduced improvements to the state-of-the-art remote ET prototypes for cognitive and clinical tasks, e.g. without the necessity of constant mouse interactions. Second, we assessed its spatiotemporal resolution and its reliability within an experiment. Third, we ran a classical experiment, the anti-saccade task, to assess its functionality and limitations. This cognitive test compares horizontal eye movements toward (pro-saccades) or away from (anti-saccades) a target, as a measure of inhibitory control. Our results replicated previous findings obtained with high-quality laboratory ETs. Briefly, higher error rates in anti-saccades compared to pro-saccades were observed, and incorrect responses presented faster reaction times. Our web-ET prototype showed a stable calibration over time and performed well in a classic cognitive experiment. Finally, we discussed the potential of this prototype for clinical applications and its limitations for experimental use.
Evaluation of single-sample network inference methods for precision oncology
Authors: Deschildre Joke , Vandemoortele Boris , Loers Jens Uwe , De Preter Katleen , Vermeirssen Vanessa 
Published: July 2023

AbstractA major challenge in precision oncology is to identify targetable cancer vulnerabilities in individual patients. Modelling high-throughput omics data in biological networks allows identifying key molecules and processes of tumorigenesis. Traditionally, network inference methods rely on many samples to contain sufficient information for learning and predicting gene interactions for a group of patients. However, to implement patient-tailored approaches in precision oncology, we need to interpret omics data at the level of the individual patient. Several single-sample network inference methods have been developed that infer biological networks for an individual sample from bulk RNA-seq data. However, only a limited comparison of these methods has been made. Moreover, many methods rely on ‘normal tissue’ samples as reference point for the tumor samples, which is not always available.Here, we conducted an evaluation of the single-sample network inference methods SSN, LIONESS, iENA, CSN and SSPGI using expression profiles of lung and brain cancer cell lines from the CCLE database. The methods constructed networks with distinct network topologies, as observed by edge weight distributions and other network characteristics. Further, hub gene analyses revealed different degrees of subtype-specificity across methods. Single-sample networks were able to distinguish between tumor subtypes, as exemplified by edge weight clustering, enrichment of known subtype-specific driver genes among hub gene sets, and differential node importance. Finally, we show that single-sample networks correlate better to other omics data from the same cell line as compared to aggregate networks. Our results point to the important role of single-sample network inference in precision medicine.
High quality genome assembly and annotation (v1) of the eukaryotic terrestrial microalgaCoccomyxa viridisSAG 216-4
Authors: Kraege Anton , Chavarro-Carrero Edgar A. , Guiglielmoni Nadège , Schnell Eva , Kirangwa Joseph , Heilmann-Heimbach Stefanie , Becker Kerstin , Köhrer Karl ,   WGGC Team,   DeRGA Community, Schiffer Philipp , Thomma Bart P. H. J. , Rovenich Hanna 
Published: July 2023

AbstractUnicellular green algae of the genusCoccomyxaare recognized for their worldwide distribution and ecological versatility. Most species described to date live in close association with various host species, such as in lichen associations. However, little is known about the molecular mechanisms that drive such symbiotic lifestyles. We generated a high-quality genome assembly for the lichen photobiontCoccomyxa viridisSAG 216-4 (formerlyC. mucigena). Using long-read PacBio HiFi and Oxford Nanopore Technologies in combination with chromatin conformation capture (Hi-C) sequencing, we assembled the genome into 21 scaffolds with a total length of 50.9 Mb, an N50 of 2.7 Mb and a BUSCO score of 98.6%. While 19 scaffolds represent full-length nuclear chromosomes, two additional scaffolds represent the mitochondrial and plastid genomes. Transcriptome-guided gene annotation resulted in the identification of 13,557 protein-coding genes, of which 68% have annotated PFAM domains and 962 are predicted to be secreted.