bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mammography and Ultrasonography Manifestations of Sclerosing Lymphocytic
Lobulitis of the Breast: A Series of Seven Case Reports
Authors: Lin Wanling , Bao Lingyun 
Published: September 2023

Objective:
The present study aimed to analyze mammography and ultrasonography (US) manifestations of sclerosing lymphocytic lobulitis (SLL) of the breast.

Methods:
A total of 8 pathologically confirmed SLL lesions from seven women (with one patient having bilateral breast lesions) were included in the study. All patients underwent preoperative mammography and US examinations. The findings from both modalities were classified and compared to their corresponding clinical data.

Results:
Four patients were diagnosed with diabetes mellitus. Mammography results revealed that seven lesions presented as focal asymmetry or asymmetry. Seven lesions were observed as non-mass lesions on US examination. The most commonly observed US lesion features were as follows: seven lesions had focal non-ductal hypoechoic areas (87.5%), seven lesions exhibited posterior shadowing (87.5%), all lesions showed no vascularity or vessels in the rim (100%), no lesion had calcifications (0%), five lesions had an elasticity score of 3 (100%), one lesion showed retraction on the coronal plane (20%), and one lesion displayed a skipping sign on the coronal plane (20%). Based on these US findings, seven lesions (87.5%) were classified as BI-RADS 4.

Conclusion:
The mammography findings for SLL are often nonspecific. However, the US features of SLL typically present as non-mass lesions. The absence of calcification and vascularity and no retraction on the coronal plane inside the lesion may help to differentiate this disease from the conventional forms of breast carcinoma.
Characterization of Central and Nasal Orbital Adipose Stem Cells and
their Neural Differentiation Footprints
Authors: Sanie-Jahromi Fatemeh , Nowroozzadeh M. Hossein , Shaabanian Mina , Khademi Behzad , Owji Naser , Mehrabani Davood 
Published: September 2023

Background:
The unique potential of stem cells to restore vision and regenerate damaged ocular cells has led to the increased attraction of researchers and ophthalmologists to ocular regenerative medicine in recent decades. In addition, advantages such as easy access to ocular tissues, non-invasive follow-up, and ocular immunologic privilege have enhanced the desire to develop ocular regenerative medicine.

Objective:
This study aimed to characterize central and nasal orbital adipose stem cells (OASCs) and their neural differentiation potential.

Methods:
The central and nasal orbital adipose tissues extracted during an upper blepharoplasty surgery were explant-cultured in Dulbecco’s Modified Eagle Medium (DMEM)/F12 supplemented with 10% fetal bovine serum (FBS). Cells from passage 3 were characterized morphologically by osteogenic and adipogenic differentiation potential and by flow cytometry for expression of mesenchymal (CD73, CD90, and CD105) and hematopoietic (CD34 and CD45) markers. The potential of OASCs for the expression of NGF, PI3K, and MAPK and to induce neurogenesis was assessed by real-time PCR.

Results:
OASCs were spindle-shaped and positive for adipogenic and osteogenic induction. They were also positive for mesenchymal and negative for hematopoietic markers. They were positive for NGF expression in the absence of any significant alteration in the expression of PI3K and MAPK genes. Nasal OASCs had higher expression of CD90, higher potential for adipogenesis, a higher level of NGF expression under serum-free supplementation, and more potential for neuron-like morphology.

Conclusion:
We suggested the explant method of culture as an easy and suitable method for the expansion of OASCs. Our findings denote mesenchymal properties of both central and nasal OASCs, while mesenchymal and neural characteristics were expressed stronger in nasal OASCs when compared to central ones. These findings can be added to the literature when cell transplantation is targeted in the treatment of neuro-retinal degenerative disorders.
Deciphering the Role of Peroxisome Proliferator-activated Receptor α and
Phosphodiesterase Type 5 Targets in Alzheimer's Disease
Authors: Sose Parnika M. , Kale Pravin P. , Doshi Gaurav M. 
Published: September 2023

Abstract:
The most prevalent cause of dementia is Alzheimer's disease (AD). Although the global AD
rate is on a constant rise, medical research is yet to find a cure for this neurological condition. Current
available therapeutic drugs for AD treatment only provide symptomatic alleviation. Therefore, it is essential
to establish effective AD treatment strategies in addressing clinical needs. The development of
disease-modifying treatments for use in the disease's early stages and the advancement of symptomatic
drugs principally used in the disease's later stages are priorities in AD research. Given that the etiology
of AD is difficult to comprehend, using a multimodal therapy intervention that targets molecular targets
of AD-related degenerative processes is a practical strategy to change the course of AD progression.
The current review article discussed PPAR-α (Peroxisome proliferator-activated receptor-α) and
PDE5 (Phosphodiesterase type 5) targets with evidence for their preclinical and clinical importance.
Furthermore, we support the targets with AD-related processes, functions, and remedial measures. A
unique synergistic method for treating AD may involve the beneficial combinatorial targeting of these
two receptors. Furthermore, we reviewed different PDE chemical families in this research and identified
PDE5 inhibitors as one of the promising AD-related experimental and clinical disease-modifying
medications. Lastly, we suggest jointly targeting these two pathways would be more beneficial than
monotherapy in AD treatments.
Protecting Cloud Computing Environments from Malicious Attacks using Multi-factor Authentication and Modified DNA Cryptography
Authors: Rawther Shiju , Sivaji Sathyalakshmi 
Published: September 2023

Introduction:
Cloud computing has become an essential technology for data storage and
sharing, but security concerns remain significant challenges. Authentication is one of the critical
components of cloud security. Various authentication schemes have been proposed to ensure the
confidentiality and integrity of cloud data.

Method:
This research paper reviews the state-of-the-art three-factor authentication schemes based
on smart cards, biometric authentication, and elliptic curve cryptography. The paper also presents a
comprehensive overview of DNA cryptography algorithms, which have recently gained popularity
due to their unique features in cloud data security. The paper further compares the DNA cryptography
algorithms and discusses their advantages and disadvantages in terms of security and performance.

Results:
Finally, the paper proposes an efficient and secure DNA-based authentication scheme for
cloud computing. This scheme is validated using all these types of data, and its performance is evaluated
in terms of encryption and decryption times. Decryption takes 60 seconds on average and encryption
40 seconds on average.

Conclusion:
As a final evaluation, it establishes that the proposed system can provide secure cloud
services.
Fabrication of Eucalyptus Oil-loaded Ciprofloxacin Hydrochloride Topical
Films for Enhanced Treatment of Post-Operative Wound Infection
Authors: Parmar Rakeshkumar , Kalal Nimisha , Patel Janki , Chauhan Payal 
Published: September 2023

Background:
The efficacious penetration of antimicrobials at infectious sites and the reduction of microbial resistance development are critical in controlling the effective treatment of post-operative wound infection.

Methods:
To create the enhanced antimicrobial topical films, a solvent casting method for ciprofloxacin hydrochloride (CiproHCl) loaded eucalyptus oil (EO) containing low molecular weight chitosan films was used. Nine batches of CiproHCl with varying chitosan and glycerol concentrations were prepared and tested. Additionally, optimised CiproHCl films with EO were created and tested. The antimicrobial activity of CiproHCl-loaded EO containing low molecular weight chitosan films against S. Aureus, E. Coli, and B. Subtilus was tested.

Results:
The FT-IR spectroscopy and DSC analysis revealed no interaction between the drug and any of the other excipients, and the drug remained amorphous in chitosan film. The SEM analysis revealed that the prepared CiproHCl-loaded EO-containing films had smooth surfaces and large agglomerates. In vitro drug release testing revealed that the EO-loaded films have a sustained release profile of up to 16 hours with a cumulative drug release of 96.83%. In an ex vivo drug permeation study, CiproHCl-loaded EO-containing films demonstrated 2.44 times more permeation flux than CiproHCl-alone films. After six months, the stability study revealed that the CiproHCl-loaded EO-loaded EO-containing film showed no significant change in drug release profile or folding endurance.

Conclusion:
This present study highlights the possible usage of CiproHCl-loaded EO containing low molecular weight chitosan films in enhanced post-operative wound treatment.
Hybrid Aluminized Fiberglass Reinforced Composite Pipes: A Framework for Safety Use in Industries
Authors: Vasanthanathan Arunachalam , Narayanan Umesh Pattu Sowmya , Amudhan Kannan 
Published: September 2023

Introduction:
Polymer matrix composites have been utilized in various industries
due to their low cost and good strength-to-weight ratios. AIM: This study aims to
investigate the effectiveness of filament-wound fiber-reinforced polymer composite
pipes. The focus is on aluminized fabric tubes, which are flexible and heat-resistant tubes
made from a glass fabric and laminated with a layer of aluminum.

Method:
These tubes offer unique properties that make them suitable for various applications,
especially in environments with high temperatures or exposure to radiant heat.
Fiber Reinforced Plastic (FRP) pipes are highlighted for their lightweight, easy transportation,
low maintenance, corrosion resistance, design flexibility, and anti-freezing performance.
The study delves into the use of aluminized glass fiber for high-temperature
applications, with a specific focus on enhancing high-temperature withstanding properties.

Result:
In addition, the present research also conducts tests to study the structural
strength of normal glass fabric tubes and aluminized glass fabric tubes. The fabrication
of composite pipes is achieved through a filament winding process with a zero-degree
winding angle using a manually operated filament winding machine. Mechanical testing
and Finite Element Analysis (FEA) simulations using ANSYS® are also performed to
compare glass fiber-reinforced plastic pipes with hybrid aluminized fiber-reinforced
plastic pipes.

Conclusion:
The application of aluminized glass fiber in both the internal and external
layers of the pipes improves the pipe’s strength and ability to endure high temperatures.
Investigation of Reported Anaphylaxis Post COVID-19 Vaccination in
Subjects with History of Allergies and Anaphylaxis
Authors: Desai Aditya P. , Desai Aryan P. , Ochs Victoria S. , Desai Prashant V. 
Published: September 2023

Background:
Two mRNA COVID-19 vaccines, Pfizer-BioNTech and Moderna, are currently
approved in the United States, and one viral-vector vaccine, J&J/Janssen, is authorized for limited use.
The Vaccine Adverse Event Reporting System (VAERS) database gathers reports of adverse effects, including anaphylaxis.

Objective:
In this manuscript, we provide a summary of reported incidence of anaphylaxis rates following
administration of the two mRNA and one viral-vector COVID-19 vaccine.

Methods:
A detailed investigation of the relative risk of anaphylaxis for recipients with or without a prior
history of allergy and/or anaphylaxis is also described.

Results:
Overall reported incidence of anaphylaxis is 4.49 [95% CI: 0.25 – 8.73] cases per million doses
administered.

Conclusion:
The reported risk of anaphylaxis is 1.83 times greater for recipients with prior allergies and
no anaphylaxis but 17.70 times greater for recipients with prior allergies and anaphylaxis.
A Mobile App (Concerto) to Empower Hospitalized Patients in a Swiss University Hospital: Development, Design, and Implementation Report
Authors: Dietrich Damien , Bornet dit Vorgeat Helena , Perrin Franck Caroline , Ligier Quentin 
Published: September 2023

Background
Patient empowerment can be associated with better health outcomes, especially in the management of chronic diseases. Digital health has the potential to promote patient empowerment.

Objective
Concerto is a mobile app designed to promote patient empowerment in an in-patient setting. This implementation report focuses on the lessons learned during its implementation.

Methods
The app was conceptualized and prototyped during a hackathon. Concerto uses hospital information system (HIS) data to offer the following key functionalities: a care schedule, targeted medical information, practical information, information about the on-duty care team, and a medical round preparation module. Funding was obtained following a feasibility study, and the app was developed and implemented in four pilot divisions of a Swiss University Hospital using institution-owned tablets.

Implementation (Results)
The project lasted for 2 years with effective implementation in the four pilot divisions and was maintained within budget. The induced workload on caregivers impaired project sustainability and warranted a change in our implementation strategy. The presence of a killer function would have facilitated the deployment. Furthermore, our experience is in line with the well-accepted need for both high-quality user training and a suitable selection of superusers. Finally, by presenting HIS data directly to the patient, Concerto highlighted the data that are not fit for purpose and triggered data curation and standardization initiatives.

Conclusions
This implementation report presents a real-world example of designing, developing, and implementing a patient-empowering mobile app in a university hospital in-patient setting with a particular focus on the lessons learned. One limitation of the study is the lack of definition of a “key success” indicator.
Longitudinal Evaluation of an Integrated Post–COVID-19/Long COVID Management Program Consisting of Digital Interventions and Personal Support: Randomized Controlled Trial
Authors: Derksen Christina , Rinn Robin , Gao Lingling , Dahmen Alina , Cordes Cay , Kolb Carina , Becker Petra , Lippke Sonia 
Published: September 2023

Background
The postacute COVID-19 syndrome (PACS) can be addressed with multidisciplinary approaches, including professional support and digital interventions.

Objective
This research aimed to test whether patients who received a health care facilitation program including medical internet support from human personal pilots and digital interventions (intervention group [IG] and active control group [ACG]) would experience fewer symptoms and have higher work ability and social participation than an untreated comparison group (CompG). The second objective was to compare the impact of a diagnostic assessment and digital interventions tailored to patients’ personal capacity (IG) with that of only personal support and digital interventions targeting the main symptoms (ACG).

Methods
In total, 1020 patients with PACS were recruited. Using a randomized controlled trial design between the IG and the ACG, as well as propensity score matching to include the CompG, analyses were run with logistic regression and hierarchical-linear models.

Results
Symptoms decreased significantly in all groups over time (βT1-T2=0.13, t549=5.67, P<.001; βT2-T4=0.06, t549=2.83, P=.01), with a main effect of the group (β=–.15, t549=–2.65, P=.01) and a more pronounced effect in the IG and ACG compared to the CompG (between groups: βT1-T2=0.14, t549=4.31, P<.001; βT2-T4=0.14, t549=4.57, P<.001). Work ability and social participation were lower in the CompG, but there was no significant interaction effect. There were no group differences between the IG and the ACG.

Conclusions
Empowerment through personal pilots and digital interventions reduces symptoms but does not increase work ability and social participation. More longitudinal research is needed to evaluate the effects of a diagnostic assessment. Social support and digital interventions should be incorporated to facilitate health care interventions for PACS.

Trial Registration
ClinicalTrials.gov NCT05238415; https://classic.clinicaltrials.gov/ct2/show/NCT05238415.

International Registered Report Identifier (IRRID)
RR2-10.1186/s12879-022-07584-z
Obinutuzumab in Frequently Relapsing and Steroid-Dependent Nephrotic Syndrome in Children
Authors: Dossier Claire , Bonneric Stéphanie , Baudouin Véronique , Kwon Thérésa , Prim Benjamin , Cambier Alexandra , Couderc Anne , Moreau Christelle , Deschenes Georges , Hogan Julien 
Published: September 2023

Background
B-cell depletion with rituximab induces sustained remission in children with steroid-dependent or frequently relapsing nephrotic syndrome. However, most patients relapse after B-cell recovery, and some patients do not achieve B-cell depletion. Obinutuzumab is a second-generation anti-CD20 antibody designed to overcome such situations in B-cell malignancies and was recently reported to be safe and effective in other autoimmune diseases affecting the kidneys.

Methods
We retrospectively report 41 children with steroid-dependent or frequently relapsing nephrotic syndrome treated with a single low-dose infusion of obinutuzumab at Robert-Debre Hospital between April 2018 and December 2020. Participants were treated because of rituximab resistance or relapse after rituximab and received a single infusion of 300 mg/1.73 m2 obinutuzumab with cessation of oral immunosuppressors within 2 months.

Results
B-cell depletion was achieved in all participants and lasted a median of 8.3 months (interquartile range, 6.4–11.1), a duration exceeding that for last rituximab treatment. At 12 and 24 months, 92% (38/41) and 68% (28/41) of patients, respectively, were in sustained remission. Mild infusion reactions occurred in five participants (12%) and neutropenia in nine (21%). No significant decrease in IgG level was reported during treatment, and whereas IgM levels decreased in 34 patients (83%), they were normal at last follow-up in 32 (78%).

Conclusions
These results identified low-dose obinituzumab as a promising treatment option in children with steroid-dependent or frequently relapsing nephrotic syndrome, including those resistant to rituximab. The tolerance profile of obinutuzumab was similar to that of rituximab, but hemogram and immunoglobulin levels should be monitored.
Anxiety and Risk Perception in Parents of Children Identified by Population Screening as High Risk for Type 1 Diabetes
Authors: O’Donnell Holly K. , Rasmussen Cristy Geno , Dong Fran , Simmons Kimber M. , Steck Andrea K. , Frohnert Brigitte I. , Bautista Kimberly , Rewers Marian J. , Baxter Judith ,   ASK Study Group, Rewers Marian J. , Bautista Kimberly , Baxter Judith , Felipe-Morales Daniel , Dong Fran , Driscoll Kimberly , Frohnert Brigitte I. , Rasmussen Cristy Geno , Gesualdo Patricia , Hoffman Michelle , Karban Rachel , O’Donnell Holly K. , Pauley Meghan , Sepulveda Flor , Silva Crystal , Simmons Kimber M. , Steck Andrea K. , Taki Iman , Waugh Kathleen , Jia Xiaofan , Yu Liping , Liu Edwin , Stahl Marisa , McQueen R. Brett , Norris Jill M. , Frost Holly , O’Leary Sonja , Middlemist Martha 
Published: September 2023

OBJECTIVE
To assess anxiety and risk perception among parents whose children screened positive for islet autoantibodies, indicating elevated risk for type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
The Autoimmunity Screening for Kids (ASK) study identified 319 children age 1 to 17 years at risk for T1D via screening for islet autoantibodies; 280 children with confirmed islet autoantibodies and their caregivers enrolled in a follow-up education and monitoring program to prevent diabetic ketoacidosis at diagnosis. Parents completed questionnaires at each monitoring visit, including a 6-item version of the State Anxiety Inventory (SAI), to assess anxiety about their child developing T1D, and a single question to assess risk perception.

RESULTS
At the first ASK follow-up monitoring visit, mean parental anxiety was elevated above the clinical cutoff of 40 (SAI 46.1 ± 11.2). At the second follow-up monitoring visit (i.e., visit 2), mean anxiety remained elevated but started to trend down. Approximately half (48.9%) of parents reported their child was at increased risk for T1D at the initial follow-up monitoring visit (visit 1). Parents of children with more than one islet autoantibody and a first-degree relative with T1D were more likely to report their child was at increased risk.

CONCLUSIONS
Most parents of autoantibody-positive children have high anxiety about their child developing T1D. Information about the risk of developing T1D is difficult to convey, as evidenced by the wide range of risk perception reported in this sample.
Ekplorasi Motivasi Belajar Mahasiswa UIN Walisongo Semarang pada Pembelajaran Kimia
Authors: Hafizhah Zakia 
Published: September 2023

Penelitian ini bertujuan untuk menganalisis motivasi belajar mahasiswa UIN Walisongo saat pembelajaran di kelas. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survey. Penelitian ini dilakukan di UIN Walisongo Semarang dengan melibatkan 60 mahasiswa pendidikan kimia dari semester 2 sampai 6. Teknik pengumpulan data pada penelitian ini menggunakan teknik survey dengan skala likert. Adapun survey dibuat dalam google form agar mudah diakses oleh mahasiswa. Teknik analisis data yang digunakan dalam penelitian ini adalah menghitung presentase data dari setiap indikatornya. Hasil penelitian ini menujukkan bahwa saat pembelajaran di kelas motivasi belajar mahasiswa pendidikan kimia UIN Walisongo Semarang dalam kategori cukup, hal tersebut didapatkan dari skor rata-rata presentase motivasi belajar yang berjumlah 46,31%.
Revision of fluoroquinolone breakpoints used for interpretation of antimicrobial susceptibility testing of canine bacterial isolates
Authors: Papich Mark G. , Gunnett Lacie A. , Lubbers Brian V. 
Published: September 2023

Abstract
The fluoroquinolone antimicrobial agents, enrofloxacin and marbofloxacin, were US Food and Drug Administration (FDA) approved in the United States for use in dogs in 1988 and 1999, respectively. There have been many advances since then concerning the pharmacokinetic-pharmacodynamic (PK-PD) evaluation of fluoroquinolones, and there are data available on the susceptibility of targeted pathogens since the original approval. Using this information, the Clinical and Laboratory Standards Institute (CLSI) Veterinary Antimicrobial Susceptibility Testing Subcommittee (VAST) revised its antimicrobial susceptibility testing breakpoints. The previous breakpoints (used in older editions of CLSI standards) for enrofloxacin in dogs were susceptible (S), ≤ 0.5 µg/mL, intermediate (I) 1–2 µg/mL, and resistant (R) ≥ 4 µg/mL. The new breakpoints are S ≤ 0.06 µg/mL for a dose of 5 mg/kg, 0.12 µg/mL for a dose of 10 mg/kg, 0.25 µg/mL for a high dose of 20 mg/kg, and R ≥ 0.5 µg/mL. The breakpoints of 0.12 and 0.25 µg/mL represent a new susceptible-dose dependent (SDD) category. For marbofloxacin, previous breakpoints were S, ≤ 1 µg/mL, I 2 µg/mL, and R ≥ 4 µg/mL. The new breakpoints are S ≤ 0.12 µg/mL for a dose of 2.8 mg/kg, 0.25 µg/mL for a dose of 5.5 mg/kg (SDD), and R ≥ 0.5 µg/mL. The new breakpoints will be published in the next edition of CLSI-Vet01(S) and deviate considerably from the prior breakpoints. Laboratories are encouraged to revise their testing standards. These changes will likely reduce the unnecessary use of these fluoroquinolones in dogs.