bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualizing GABA transporters in vivo: an overview of reported radioligands and future directions
Authors: Knippenberg Niels , Bauwens Matthias , Schijns Olaf , Hoogland Govert , Florea Alexandru , Rijkers Kim , Cleij Thomas J. , Eersels Kasper , van Grinsven Bart , Diliën Hanne 
Published: May 2023

AbstractBy clearing GABA from the synaptic cleft, GABA transporters (GATs) play an essential role in inhibitory neurotransmission. Consequently, in vivo visualization of GATs can be a valuable diagnostic tool and biomarker for various psychiatric and neurological disorders. Not surprisingly, in recent years several research attempts to develop a radioligand have been conducted, but so far none have led to suitable radioligands that allow imaging of GATs. Here, we provide an overview of the radioligands that were developed with a focus on GAT1, since this is the most abundant transporter and most of the research concerns this GAT subtype. Initially, we focus on the field of GAT1 inhibitors, after which we discuss the development of GAT1 radioligands based on these inhibitors. We hypothesize that the radioligands developed so far have been unsuccessful due to the zwitterionic nature of their nipecotic acid moiety. To overcome this problem, the use of non-classical GAT inhibitors as basis for GAT1 radioligands or the use of carboxylic acid bioisosteres may be considered. As the latter structural modification has already been used in the field of GAT1 inhibitors, this option seems particularly viable and could lead to the development of more successful GAT1 radioligands in the future.
Mergers and acquisitions: does performance depend on managerial ability?
Authors: Suryaningrum Diah Hari , Abdul Rahman Abdul Aziz , Meero Abdelrhman , Cakranegara Pandu Adi 
Published: May 2023

AbstractCompanies in difficult financial situations may seek to survive through mergers and acquisitions. Managers must be able to use company resources efficiently to maintain and improve competitiveness and sustainable advantages. Managers' ability to make strategic decisions may determine whether a merger and acquisition is successful. This study aims to reveal the role of the acquirer's managerial ability in mergers and acquisitions based on short- and long-term performance as well as the type of M&A. Two metrics are used to assess short- and long-term performance: the market-to-book ratio (MTBR) as an indicator of operating performance and the buy-and-hold abnormal return (BHAR) as an indicator of stock return performance. The research sample consists of 153 M&A cases conducted by companies registered with the Business Competition Supervisory Commission in Indonesia between 2010 and 2017, and the performance till 2020. We used regression and difference analysis to analyze the data. We find that managerial ability has a positive impact on MTBR operating and BHAR stock performance. This result confirms that the higher ability of the acquirer's manager will ensure a successful M&A in the long run. Investors and potential investors might consider managerial ability in choosing investments in companies after an M&A. This study contributes to the M&A literature by examining the role of MA in the short- and long-term performance of acquiring firms following M&As in Indonesia.
Intraoperative pleth variability index-based fluid management therapy and gastrointestinal surgical outcomes in elderly patients: a randomised controlled trial
Authors: Wang Yu , Zhang Yue , Zheng Jin , Dong Xue , Wu Caineng , Guo Zhijia , Wu Xinhai 
Published: May 2023

Abstract
Background
Intraoperative goal-directed fluid therapy (GDFT) has been reported to reduce postoperative complications of patients undergoing major abdominal surgery. The clinical benefits of pleth variability index (PVI)-directed fluid management for gastrointestinal (GI) surgical patients remain unclear. Therefore, this study aimed to evaluate the impact of PVI-directed GDFT on GI surgical outcomes in elderly patients.

Methods
This randomised controlled trial was conducted in two university teaching hospitals from November 2017 to December 2020. In total, 220 older adults undergoing GI surgery were randomised to the GDFT or conventional fluid therapy (CFT) group (n = 110 each). The primary outcome was a composite of complications within 30 postoperative days. The secondary outcomes were cardiopulmonary complications, time to first flatus, postoperative nausea and vomiting, and postoperative length of stay.

Results
The total volumes of fluid administered were less in the GDFT group than in the CFT group (2.075 L versus [vs.] 2.5 L, P = 0.008). In intention-to-treat analysis, there was no difference in overall complications between the CFT group (41.3%) and GDFT group (43.0%) (odds ratio [OR] = 0.935; 95% confidence interval [CI], 0.541–1.615; P = 0.809). The proportion of cardiopulmonary complications was higher in the CFT group than in the GDFT group (19.2% vs. 8.4%; OR = 2.593, 95% CI, 1.120–5.999; P = 0.022). No other differences were identified between the two groups.

Conclusions
Among elderly patients undergoing GI surgery, intraoperative GDFT based on the simple and non-invasive PVI did not reduce the occurrence of composite postoperative complications but was associated with a lower cardiopulmonary complication rate than usual fluid management.

Trial registration
This trial was registered with the Chinese Clinical Trial Registry (ChiCTR-TRC-17012220) on 1 August 2017.
Epidemiology of community origin of major multidrug-resistant ESKAPE uropathogens in a paediatric population in South-East Gabon
Authors: Mouanga-Ndzime Yann , Onanga Richard , Longo-Pendy Neil-Michel , Bignoumba Michelle , Bisseye Cyrille 
Published: May 2023

Abstract
Background
Urinary tract infections (UTIs) in children are very common. They are often associated with a high risk of sepsis and death. In recent years, antibiotic-resistant uropathogens ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae) are increasingly encountered in UTIs. These bacteria, usually multidrug-resistance (MDR), extensive drug-resistance (XDR), pandrug-resistance (PDR), Extended-spectrum cephalosporin-resistance (ESC), Usual Drug Resistance (UDR), Difficult-to-Treat Resistance (DTR) and Carbapenem-resistance Enterobacteriales (CRE), represent a global threat for the management of paediatric UTIs. The aim of this study was to determine the epidemiology of community origin and antibiotic sensitivity of major ESKAPE uropathogens in paediatric UTIs in South-East Gabon.

Methods
The study involved 508 children aged 0–17 years. Identification of bacterial isolates was carried out using Vitek-2 compact automated system and the antibiogram with the disk diffusion and microdilution methods according to the European Committee on Antimicrobial Susceptibility Testing recommendations. Logistic regression analysis was used to assess the impact of patients' socio-clinical characteristics on uropathogens phenotype in both univariate and multivariate analysis.

Results
The prevalence of UTIs was 59%. E. coli (35%) and K. pneumoniae (34%) were the main ESKAPE involved in UTIs followed by Enterococcus spp. (8%) and S. aureus (6%). Among major ESKAPE, DTR-E. coli (p = 0.01), CRE-E. coli (p = 0.02) and XDR-E. coli (p = 0.03), Trimethoprim-sulfamethoxazole-resistant bacteria (p = 0.03) were associated with abdomino-pelvic pain. While MDR-E. coli (p < 0.001), UDR-E. coli (p = 0.02), ESC-E. coli (p < 0.001), MDR- Enterococcus (p = 0.04), UDR- Enterococcus (p = 0.02), bacteria resistant to Ampicillin (p < 0.01), Cefotaxime (p = 0.04), Ciprofloxacin (p < 0.001), Benzylpenicillin (p = 0.03) and Amikacin (p = 0.04) were more frequent among male children. MDR-Enterococcus (p < 0.01), bacteria resistant to Amoxicillin-clavulanic acid (p = 0.03), Cefalotin (p = 0.01), Ampicillin (p = 0.02) and Gentamicin (p = 0.03) were associated with treatment failure. In addition, Trimethoprim-sulfamethoxazole-resistant bacteria (p = 0.03) was associated with recurrent UTIs while those resistant to Ciprofloxacin was associated with pollakiuria (p = 0.01) and urinary burning (p = 0.04). Furthermore, UDR-K. pneumoniae (p = 0.02) was more frequent in neonates and infants.

Conclusion
This study determined the epidemiology of ESKAPE uropathogens in paediatric UTIs. It found a high prevalence of paediatric UTIs associated with children’s socio-clinical characteristics and diverse bacterial antibiotic resistance phenotypes.
A risk score to predict 30-day hospital readmission rate in cirrhotic patients with spontaneous bacterial peritonitis
Authors: Mousa Nasser , Abdel-Razik Ahmed , Elbaz Sherif , Salah Mohamed , Abdelaziz Mohammed , Habib Alaa , Deib Ahmed , Gadallah Abdel-Naser , El-wakeel Niveen , Eldars Waleed , effat Narmin , El-Emam Ola , Taha Khaled , Elmetwalli Alaa , Mousa Eman , Elhammady Dina 
Published: May 2023

Abstract
Background and aim
There is lack of 30-day hospital readmission prediction score in patients with liver cirrhosis and SBP. The aim of this study is to recognize factors capable of predicting 30-day readmission and to develop a readmission risk score in patients with SBP.

Methods
This study prospectively examined the 30-day hospital readmission for patients previously discharged with a diagnosis of SBP. Based on index hospitalization variables, a multivariable logistic regression model was implemented to recognize predictors of patient hospital readmission within 30 days. Consequently, Mousa readmission risk score was established to predict 30-day hospital readmission.

Results
Of 475 patients hospitalized with SBP, 400 patients were included in this study. The 30-day readmission rate was 26.5%, with 16.03% of patients readmitted with SBP. Age ≥ 60, MELD > 15, serum bilirubin > 1.5 mg/dL, creatinine > 1.2 mg/dL, INR > 1.4, albumin < 2.5 g/dL, platelets count ≤ 74 (103/dL) were found to be independent predictors of 30-day readmission. Incorporating these predictors, Mousa readmission score was established to predict 30-day patient readmissions. ROC curve analysis demonstrated that at a cutoff value ≥ 4, Mousa score had optimum discriminative power for predicting the readmission in SBP with sensitivity 90.6% and specificity 92.9%. However, at cutoff value ≥ 6 the sensitivity and specificity were 77.4% and 99.7%, respectively, while a cutoff value ≥ 2 had sensitivity of 99.1% and specificity of 31.6%.

Conclusions
The 30-day readmission rate of SBP was 25.6%. With the suggested simple risk assessment Mousa score, patients at high risk for early readmission can be easily identified so as to possibly prevent poorer outcomes.
Is agricultural digitization a reality among smallholder farmers in Africa? Unpacking farmers' lived realities of engagement with digital tools and services in rural Northern Ghana
Authors: Abdulai Abdul-Rahim , Tetteh Quarshie Philip , Duncan Emily , Fraser Evan 
Published: May 2023

Abstract
Background
Digital technologies are promoted as transformational for smallholders in Africa through the potential to enhance access to knowledge, increase productivity and food security. Despite the anticipations for agricultural digitalization in Africa, smallholders' engagement with digitalization is empirically underexplored. Hence, we surveyed 1565 rural farmers in Northern Ghana to explore how farmers interact with digital tools and services, and the variations in their engagements.

Results
We found that despite the growing array of digital opportunities (with diverse tools and services available to farmers), farmers are mainly confined to simple devices (mobile phones, radio, and TV) as access to digital resources, including the internet remains limited. Meanwhile, the main sources of digitalization services for smallholders remain largely the highly subisidized, development-orieted. NGOs and private-sector projects, which generally leverage SMS, Interactive Voice Response (IVR), radio, or field agents to reach farmers. Nonetheless, participation in digitalization services remains limited, unimpressive at best, and often fades over time because of weak building blocks evident in low literacies, lack of digital competencies and the limited access to digital resources.

Conclusions
Thus, full-scale digitalization remains a distant goal, and transformation claims are disconnected from smallholders' lived realities. However, opportunities exist to create a ‘digitalization for smallholders’ that is sensitive to the current and future structural limitations of smallholder agriculture, including low literacy and limited access to digital tools, to make agriculture digitalization reach its full potential in Africa.
Feelings toward lying flatism and attitudes toward singlehood: the mediating role of happiness belief
Authors: Heng Zeng-Qing , Chin Joey , Tan Chee-Seng 
Published: May 2023

Abstract
Background
Lying flatism, a new emerging lifestyle by refusing to participate in consumerist lifestyles, is anticipated to be related to singlehood. Based on the Theory of Reasoned Action, we proposed a mediation model to examine the indirect relationship between feelings towards lying flatism and attitudes toward singlehood via individuals’ belief in that happiness can be achieved without romantic relationships (happiness belief).

Methods
Using purposive and snowball sampling methods, 232 single Malaysian young adults participated in an online experiment consisting of a writing task (to manipulate feelings toward lying flatism), single-item measures of manipulation checking and happiness belief, Attitudes toward Singlehood Scale, Negative Stereotyping of Single Persons Scale (a measure of singlism) and Fear of Being Single Scale.

Results
T-Test results support the writing task that successfully induced positive feelings toward lying flatism. Mediation analysis showed that the feelings toward lying flatism measured before the writing task, but not the manipulation of lying flatism, has an indirect relationship with attitudes toward singlehood via happiness belief, after controlling for gender, singlism, and fear of being single.

Conclusions
The findings offer preliminary support to the hypothetical relationships among feelings towards lying flatism, happiness belief, and attitudes toward singlehood. Implications of the findings are discussed.
Evaluating the psychometric properties of the fatigue severity scale using item response theory
Authors: Muranaka Seiji , Fujino Haruo , Imura Osamu 
Published: May 2023

Abstract
Background
Fatigue is a common daily experience and a symptom of various disorders. While scholars have discussed the use of the Fatigue Severity Scale (FSS) using item response theory (IRT), the characteristics of the Japanese version are not yet examined. This study evaluated the psychometric properties of the FSS using IRT and assessed its reliability and concurrent validity with a general sample in Japan.

Methods and measures
A total of 1,007 Japanese individuals participated in an online survey, with 692 of them providing valid data. Of these, 125 participants partook in a re-test after approximately 18 days and had their longitudinal data analyzed. In addition, the graded response model (GRM) was used to assess the FSS items’ characteristics.

Results
The GRM’s results recommended using seven items and a 6-point scale. The FSS’s reliability was acceptable. Furthermore, the validity was adequate from the results of correlation and regression analyses. The synchronous effects models demonstrated that the Multidimensional Fatigue Inventory (MFI) enhanced depression, and depression enhanced FSS.

Conclusion
This study suggested that the Japanese version of the FSS should be a 7-item scale with a 6-point response scale. Further investigations may reveal the different aspects of fatigue assessed by the analyzed fatigue measures.
Engagement in On-line Language Assessment: are test-taking skills, self-assessment, resilience, and autonomy critical?
Authors: Ritonga Mahyudin , Shaban Ahmad Abdulkareem , Al-Rashidi Anwar Hammad , Chilani Noam 
Published: May 2023

AbstractEvery decision made in the classroom has the potential to either help or hurt a student’s development as a learner. When students’ mental and emotional well-being are taken into account, effective instruction and assessment are possible, despite the importance of learners’ engagement in assessment (LEA), test-taking skills (TTS), self-assessment (SA), learner resilience (LR), and learner autonomy (LA). As a result, this study attempted to illustrate the dynamic between LEA, TTS, SA, LR, and LA. To this end, 435 English as a foreign language (EFL) students at intermediate levels in Afghanistan were given copies of the Test-taking Skills Scale (TTSS), the core of self‑assessments questionnaire (CSAQ), The Academic Resilience Scale (ARS), the learner autonomy questionnaire (LAQ), and the learner engagement in on-line assessment (LEOA). Confirmatory factor analysis (CFA) and structural equation modeling (SEM) screening of the data revealed that resilient EFL students feel better at on-line assessment and in pursuing their objectives. The mediating effects of TTS and SA on LR and LA and consequently Engagement in On-line Assessment were specifically identified. The survey’s ramifications, which may improve language learning and assessment, are reviewed at length.
Late chronic local inflammation, synaptic alterations, vascular remodeling and arteriovenous malformations in the brains of male rats exposed to repetitive low-level blast overpressures
Authors: Gama Sosa Miguel A. , De Gasperi Rita , Pryor Dylan , Perez Garcia Georgina S. , Perez Gissel M. , Abutarboush Rania , Kawoos Usmah , Hogg Seth , Ache Benjamin , Sowa Allison , Tetreault Timothy , Varghese Merina , Cook David G. , Zhu Carolyn W. , Tappan Susan J. , Janssen William G. M. , Hof Patrick R. , Ahlers Stephen T. , Elder Gregory A. 
Published: May 2023

AbstractIn the course of military operations in modern war theaters, blast exposures are associated with the development of a variety of mental health disorders associated with a post-traumatic stress disorder-related features, including anxiety, impulsivity, insomnia, suicidality, depression, and cognitive decline. Several lines of evidence indicate that acute and chronic cerebral vascular alterations are involved in the development of these blast-induced neuropsychiatric changes. In the present study, we investigated late occurring neuropathological events associated with cerebrovascular alterations in a rat model of repetitive low-level blast-exposures (3 × 74.5 kPa). The observed events included hippocampal hypoperfusion associated with late-onset inflammation, vascular extracellular matrix degeneration, synaptic structural changes and neuronal loss. We also demonstrate that arteriovenous malformations in exposed animals are a direct consequence of blast-induced tissue tears. Overall, our results further identify the cerebral vasculature as a main target for blast-induced damage and support the urgent need to develop early therapeutic approaches for the prevention of blast-induced late-onset neurovascular degenerative processes.
Analyzing the associations between motivation and academic performance via the mediator variables of specific mathematic cognitive learning strategies in different subject domains of higher education
Authors: Wild Steffen , Neef Christoph 
Published: May 2023

AbstractBackgroundThere are different teaching methods and learning content in the academic field of mathematics between school and university. Many students fail in their studies when the proportion of mathematics is high. Additionally, dropout rates, due to mathematical performance, are high. However, there are different strategies used to improve mathematical skills. Based on the process model of self-regulated learning, an analysis of the association between motivational aspects in the pre-action phase as well as seven special cognitive learning strategies for mathematics in the action phase was conducted. The variables were compared with student performance. The study drew on data from 548 retrospective interviews of cooperative students, using a cross-sectional research design.ResultsThe analysis via structural equation modeling shows a direct association between motivational aspects, such as academic self-concept and curiosity, and the seven learning strategies in mathematics. Furthermore, there is a direct effect of academic self-concept on performance. However, the learning strategy of practicing was the only variable with associations to performance. Additionally, the indirect effect of curiosity on performance via practicing is analyzed.ConclusionIt can be seen, that curiosity on its own is not enough to ensure a good level of performance in mathematics. The findings suggest student learning strategies focusing on harnessing their curiosity and on practicing. A high academic self-concept is also relevant to the performance level achieved. Lecturers should create a learning environment to support such student behavior.
Predicted results of the velocity structure at the target site of the blind prediction exercise from microtremors and surface wave method as Step-1, Report for the experiments for the 6th international symposium on effects of surface geology on seismic motion
Authors: Chimoto Kosuke , Yamanaka Hiroaki , Tsuno Seiji , Matsushima Shinichi 
Published: May 2023

Abstract1D velocity profiles at a strong motion station in the northern part of the Kumamoto plain, Japan, were submitted in Step-1 of the blind prediction exercise of strong ground motions in the sixth international symposium on effects of surface geology on seismic motion (ESG6). Individual participants were requested to estimate a 1D S-wave velocity profile of sedimentary layers from the given data obtained by microtremor array explorations and surface-wave explorations at the site. This paper reports the target site, methods used by the individual participants, and the submitted results. More than half of the participants estimated the phase velocities of the Rayleigh-wave in the frequency range from 0.53 to 29.8 Hz. The statistical analysis of the phase velocity dispersion curves indicates that the standard deviation was below 40 m/s at the frequencies above 3.4 Hz, and it was below 20 m/s above 20 Hz. The S-wave velocity profiles are also similar to a depth of 20 m. The standard deviation was below 45 m/s. The average S-wave velocity in the top 30 m from the surface is 207.3 ± 60.7 m/s for the submitted profiles. The large variation is related to the introduction of the near-surface low velocity layers. The large variation of the S-wave velocities was found in the deep part. The average S-wave velocity at a depth of 1500 m was 2674 m/s with the standard deviation of 786 m/s. We compared 1D amplifications for the submitted profiles. Common peaks can be identified at 0.3–0.4 Hz and 1–2 Hz, excluding two teams. However, the amplifications vary much in the frequency range higher than 4 Hz. Through the experiment, it was found that the dispersion curves and the shallow S-wave velocity structures are estimated with a low standard deviation among the participants. Further development of the techniques for deep S-wave velocity profiling was found to be required.Graphical Abstract