bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research of fault information fusion based on ICEEMDAN and PSO- SVM algorithm for rolling bearing diagnosis
Authors: Bie Fengfeng , Zhang Hanyang , Lyu Fengxia , Lu Yi , Peng Jian , Miao Yi , Shu Yu 
Published: February 2023

Abstract
As a key component of mechanical system, the extraction and accurate identification of fault characteristic information of rolling bearing is very important to ensure its normal operation. The diagnosis accuracy is occasionally low due to the limitation of information collected by a single type of data source. In this paper, the bearing vibration signal and acoustic emission signal are employed as analysis sources, a novel method based on ICCEMDAN (improved complete ensemble empirical mode decomposition with adaptive noise) with optimized SVM (support vector machine) is presented for the fault information fusion, feature extraction, and fault pattern recognition of rolling bearing. Firstly, ICEEMDAN algorithm is developed to decompose the rolling bearing vibration signal and acoustic emission signal for a series of IMF (intrinsic mode function) components. Secondly, the valuable components that can characterize the original signal status are selected based on the correlation coefficient-variance contribution criterion. Thirdly, the singular spectral entropy of the reconstructed component is calculated as the eigenvalue and the two signal eigenvectors are fused as a new eigenvector set. Finally, the feature vector set is input into the optimized SVM classifier model based on PSO optimization for training and pattern recognition, in which the accuracy and efficiency of the classifier model and SVM classifier model are compared. Study of model simulation and fault simulation experiments show that the presented model based on the singular value entropy fusion of ICEEMDAN and PSO-SVM can effectively extract the fault characteristics of rolling bearing signals and has a desired performance in the accurate pattern recognition.
Students’ game-based actions in abstract strategy board games: opening the black box
Authors: Sunay Merve Atasay , Erdogan Abdulkadir 
Published: February 2023

Abstract
Abstract strategy board games, which do not involve elements of luck and specific context, have potential to develop players’ mathematical skills, especially reasoning. In this study, the actions performed by the students in the reflected games, which aim at strategy development and implementation, were examined within the concept of milieu of the theory of didactical situations. An abstract strategy board game with a winning strategy (the square game) was chosen, and the game-playing process was designed as intra-group and inter-group games according to the main characteristic of an a-didactical milieu. Eight 7th grade students participated in the study and their games related actions were analyzed according to the reflected game functions. 13 indicators of reflected game functions were identified: 8 in the heuristic function, 3 in the explanatory function, and 2 in the checking function. The interactions between these indicators were analyzed in terms of transition between perceptual and theoretical levels to observe the evolution of the game milieu. The findings of the study showed that a number of the indicators of reflected game functions (predicting a winning move or the winner, analyzing possible moves, and perceiving a winning puzzle for the heuristic function, expressing a strategy orally or by playing for the explanatory function; generalizing strategies for the checking function) played a key role in the development of a strategy. These indicators were found to be critical in the evolution of the milieu as they allowed transitions between theoretical and perceptual levels.
Diminished PDE4D7 Expression is Associated with Treatment-Resistant, Lethal Prostate Cancer and Manifests with Impaired Androgen Response, Neuroendocrine Differentiation and Alterations in DNA Repair
Authors: Gulliver Chloe , Huss Sebastian , Semjonow Axel , Baillie George , Hoffmann Ralf 
Published: February 2023

Abstract
Androgen signalling remains the seminal therapeutic approach for management of advanced prostate cancer. However, most tumours eventually shift towards an aggressive phenotype, characterised by androgen-independence and treatment resistance. The cyclic adenosine monophosphate (cAMP) pathway plays a crucial role in regulating various cellular processes, with the phosphodiesterase PDE4D7 being a vital modulator of cAMP signalling in prostate cancer cells. Our study provides evidence that loss of PDE4D7 expression represents a pivotal switch driving the transition from an androgen-sensitive state to hormone unresponsiveness and neuroendocrine differentiation. Additionally, we demonstrate that PDE4D7 loss results affects DNA repair pathways, conferring resistance to poly ADP ribose polymerase (PARP) inhibitors. Reinstating PDE4D7 expression sensitises prostate cancer cells to anti-androgens, DNA damage response inhibitors, and cytotoxic therapies. These findings provide significant insight into the regulatory role of PDE4D7 in the development of lethal prostate cancer and the potential of its modulation as a novel therapeutic strategy.
Determinants of Low Birth Weight Among Babies Born at Gabiley General Hospital, Gabiley District, Western Somaliland. Unmatched Case Control Study
Authors: Mohamed Hamse , Abdurashid Neil , Sema Alekaw 
Published: February 2023

Abstract

Background: Low birth weight (LBW) is the weight of an infant at birth of less than 2,500 grams. It remains a major issue of public health concern globally with a disproportionate burden on low and middle income countries that leads to fetal and neonatal mortality and morbidity, poor cognitive development and an increased risk of chronic diseases later in life.
As low birth weight relates to survival, growth and wellbeing of infants throughout the life and to the investigator’s knowledge, no study has yet been done to elucidate the determinants of low birth weight in Gabiley district, Western Somaliland. Therefore, this study aimed to assess the determinants of low birth weight among babies born Gabiley General Hospital.
Methods: Facility based unmatched case control study was employed from July 1 to August 31, 2022. A total of 291 participants were included in the study of which 97 were cases and 194 were controls. The data were collected using structured and pretested interviewer administered questionnaire. The first live births of less than 2500gm in the hospital were selected as case and succeeding babies with weights of at least 2500gm as control. Data were entered using Epi-data software version 3.1 and analyzed using SPSS Version 25. The data were presented using frequency, cross-tabs and percentage. Variables with p-value < 0.25 in bivariate analysis were entered in to multivariable logistic regression and statistical significance was considered at p-value < 0.05.
Results: Over all 291 mothers with their respective newborns (97 cases and 194controls) were included in the study making the response rate of 97%. Gestational age of <37 weeks (AOR=2.18; 95 % CI: 1.11–4.29), previous history of low birth weight (AOR=2.17; 95 % CI: 1.12 - 4.21), 1st trimester hemoglobin level of <11g/dl (AOR=1.93; 95% CI: 1.06–3.50), meal frequency of two times and 3 times (AOR=4.70; 95% CI: 1.38-15.97), (AOR=4.47; 95% CI: 1.50-13.34) and MUAC <23cm (AOR=4.04; 95% CI: 2.19–7.45) were the factors significantly associated with low birth weight.
Conclusion: Factors like gestational age, previous history of low birth weight, hemoglobin level, not having additional meal during pregnancy and maternal MUAC were found to be associated with low birth weight. Therefore; nutrition education for pregnant women and strengthen antenatal care service and nutrition campaigns are needed to address the identified risk factors.
Gaze estimation using Convolutional Neural Networks
Authors: Karmi Rawdha , Rahmany Ines , KHLIFA Nawres 
Published: February 2023

Abstract
Numerous investigations on gaze estimate techniques for analyzing human behavior have been made in recent years. The majority of which have focused on gaze tracking techniques. This article proposes a new method for gaze estimation. The proposed system is divided into three phases: (i) Estimation of head position using Con-volutional neural networks CNN (VGG16, Resnet50, InceptionV3), (ii) Detection of eyes area using Viola Jones’ algorithm, and in phase (iii) gaze estimation using three different models: pre-trained CNN, CNN from scratch, as well as Bilinear Convolutional Neural Networks (B-CNNs). Columbia gaze database is used in the validation experiments. When compared to earlier efforts, the experimental results demonstrate that the proposed method produces a more exact outcome.
Effects of micro-drilling parameters on the drilling force and pore morphology of Sapindus mukorossi seeds
Authors: Zhao Suxiao , Bai Xiaopeng , Xu Daochun , Cao Wan 
Published: February 2023

Abstract
Sapindus mukorossi seeds are commonly drilled and processed into strings and other craft products. To improve the machining qualities of micro-drilling of S. mukorossi seeds, the effects of these drilling parameters on the drilling force and pore morphology were found. The mechanism behind these changes was further analyzed. The drilling parameters (feed rate, drilling speed, and drill diameter) and machining process for the micro-drilling of S. mukorossi seeds were optimized. Results indicated that each drilling parameter influenced the drilling force and hole-machining quality by affecting the amount of cutting, the working conditions of the drill bit, chip formation, and the generation of drilling heat. Moreover, the feed rate and drill diameter are main influence factors that influence the drilling force, and the drilling speed plays a leading role that influences the hole-machining quality. Interestingly, for the drilling of S. mukorossi seeds, a feed rate of 0.03 mm/r, a drilling speed of 6 m/min, and a drill-bit diameter of 0.9- or 1.5 mm resulted in a hole with high accuracy, good pore morphology, and minimal wear on the drill bit. This study facilitates the selection of suitable drilling parameters and processing technology for the micro-drilling of S. mukorossi seeds to improve the processing accuracies and qualities, and provides a theoretical basis for the improvement of related drilling processing equipment.
BMSC-derived Exosomes Attenuate Rat Osteoarthritis by Regulating Macrophage Polarization, and PINK1/Parkin Signaling May Be Involved
Authors: Li Beibei , Wu Zhiwen , Shen Enpu , Qi Hui , Wu Cheng’ai , Liu Danping , Jiang Xu 
Published: February 2023

Abstract
Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) may modulate the M1/M2 polarization of macrophages during osteoarthritis (OA). However, the underlying mechanisms of BMSC-Exos in this process still need to be elucidated. In this study, the effects of BMSC-Exos on macrophages after induction of lipopolysaccharide (LPS) were determined. The protein expression of Akt, PINK1, and Parkin in macrophages were tested. We prepared an OA model by resecting the anterior cruciate ligament and medial meniscus of SD rats. BMSC-Exos could reduce M1 and promote M2 macrophage polarization, inhibit mitochondrial membrane damage and reactive oxygen species (ROS) production. Akt phosphorylation was downregulated but significantly recovered after treatment with BMSC-Exos (P<0.01). PINK1/Parkin signaling was crucial in mitochondrial damage and subsequent M1 macrophage polarization. The protein expression of PINK1 and Parkin was significantly inhibited by BMSC-Exos (P<0.01). Histological analyses revealed that BMSC-Exos alleviated cartilage damage, inhibited M1 polarization, and promoted M2 polarization in the synovium. The expression of PINK1 and Parkin in the synovium was decreased when BMSC-Exos were used. ELISA results revealed that BMSC-Exos also changed the systematic inflammatory state. These data suggest that BMSC-Exos ameliorate OA development by regulating synovial macrophage polarization, and one of the underlying mechanisms may be through inhibiting PINK1/Parkin signaling. Therefore, BMSC-Exos are a potential useful therapeutic approach for OA.
Connectivity patterns of bottlenose dolphins (Tursiops truncatus) in the north-east Mediterranean: implications for local conservation.
Authors: Gaspari Stefania , Dooley Charlotte , Shreves Kypher , Silva Cátia S. E. , Chapman Natasha , Genov Tilen , Gonzalvo Joan , Holcer Draško , Moura Andre E. 
Published: February 2023

Abstract

Accurate description of population structure and genetic connectivity is essential for efficient conservation efforts. Along the European coastline, Tursiops truncatus typically shows high site fidelity to relatively small areas, often semi-enclosed waters, but patterns of genetic connectivity among such areas are often poorly understood. In this study, we investigate the patterns of genetic structure and connectivity of Tursiops truncatus in the Adriatic Sea and contiguous Mediterranean, where photo-ID studies suggest the occurrence of local ‘resident communities’, and a complex pattern of geographic population structure has previously been suggested. Our results are consistent with the occurrence of communities with high site fidelity to the Gulf of Ambracia, Croatian island systems and the Gulf of Trieste. Dolphins in this region do not fit a model of complete panmixia, but neither do they exhibit multiple discrete population units. Even for the community in the Gulf of Ambracia, which is well separated by several population genetic estimates, we can unambiguously identify individual dispersal to the most distant area in the Northern Adriatic Sea. We suggest that the population structure patterns in these animals might be best described as a stable metapopulation and discuss the implications of such a model for regional conservation efforts. The critically endangered Ambracian sub-population is particularly well differentiated and is therefore at high risk of local extinction due to relatively small size, high degree of isolation and exposure to several anthropogenic pressures. The exact geographic boundaries of individual sub-populations cannot always be determined due to lack of sampling and low resolution of the methods used. Nevertheless, our results have important implications for effective conservation of local communities showing strong site fidelity.
Adding Value to Low-value Eucalyptus Wood by Glulam Production: Evaluation and Prediction of Its Properties by Non- Destructive Tool
Authors: Oliveira Ramon Ferreira , Segundinho Pedro Gutemberg de Alcantara , Silva João Gabriel Missia da , Gonçalves Fabrício Gomes , Silva Jeferson Pereira Martins , Lopes Nayara Franzini , Mastela Leonor da Cunha , Paes Juarez Benigno , de Souza Clara Gaspar Fossi , Lahr Francisco Antonio Rocco 
Published: February 2023

Abstract
Eucalyptus-based glued laminated timber (glulam) was produced to determine the feasibility of a non-destructive method (drilling resistance) to predict the properties of structural elements and add value to low-value hardwood species. Glulam was manufactured with both formaldehyde and bio-based adhesives in two assembly schemes. The shear strength of the glue line (fv0), compression perpendicular to grain (Ec90 and fc90), delamination (DL), main and extended glue lines thicknesses were evaluated. Our findings indicated that the assembly schemes did not statistically influence properties and linear regression models adjusted for drilling resistance satisfactorily estimated the Ec90 and fc90.
An experiment of the light with contradictory formulas
Authors: Louiz Akram 
Published: February 2023

Abstract
Motivated by the appearance of a previous article about the light in the very useful Book titled the worldwide list of alternative theories and critics (edition 2023), I tried to propose this experiment that tries to trap light beams in a rotating environment.
I presented also the related formulas in this work and I could even guess some recurrence relations if the trapped Light-Beam is reflected several times from the moving wall of mirrors. However, the work exposes a contradiction concerning the reflected light beams velocity vectors and this made us suspect the correctness of some formulas when dealing with moving mirrors.
This proposed experiment is very interesting, but the most important are the remarks that can be made by observing the contradictions exposed in this article.
Surgical management of cancer of the stomach and gastroesophageal junction after neoadjuvant therapy: the experience of the MRRC and literature review
Authors: Skoropad V. Yu. , Kudryavtsev D. D. , Sokolov P. V. , Ivanov S. A. , Kaprin A. D. 
Published: February 2023

Itroduction. Gastric cancer incidence and mortality rates remain very high worldwide, including the Russian Federation. More than 50 % of gastric cancers are locally advanced at presentation [1]. Perioperative or adjuvant chemotherapy is a standard treatment for gastric cancer patients. The use of neoadjuvant chemoradiotherapy is considered very promising.Material and Methods. We present the analysis of the results of surgical treatment of cancer of the stomach and gastrooesophageal junction after various options of neoadjuvant therapy: chemotherapy, chemoradiotherapy, and their combinations. The experience of the Medical Radiological Research Centre (MRRC), including 5 clinical prospective studies and one randomized multicenter clinical trial, was analyzed. A total of 237 patients with histologically proven locally advanced cancer of the stomach and gastro-oesophageal junction were included into the study. Of these patients, 202 received neoadjuvant therapy. Our treatment outcomes were compared with those of randomized trials published over the last 15 years.Results. Of 202 patients who received neoadjuvant therapy, 190 (94 %) underwent surgery (R0 resection: 184 patients). In the early postoperative period, complications were observed in 62 patients (32.6 %). Re-surgery was performed in 11 (5.8 %) patients. Postoperative mortality was 1.6 % (3 patients). Multicenter randomized studies and meta-analyses, as well as the long-term experience of MRRC, have shown that neoadjuvant therapy does not increase the number of postoperative complications and mortality, increases the rate of R0 resections and improves long-term treatment outcomes in patients with resectable locally advanced cancer of the stomach and gastro-oesophageal junction.Conclusion. Analysis of long-term clinical studies conducted at the MRRC as well as the treatment results published by other authors show that in some cases neoadjuvant therapy can lead to soft tissue changes in a surgical area and may complicate surgical management; however, it does not have a negative impact on the rates of postoperative complications and mortality.
Results of multicomponent treatment of patients with progression of primary brain glioma
Authors: Sarycheva M. M. , Vazhenin A. V. , Domozhirova A. S. 
Published: February 2023

The aim of this study was to determine the most effective approach to the treatment of patients with continuous growth of brain glioma.Material and Methods. The study included 200 patients with progression of primary brain glioma, who were treated at the Chelyabinsk Regional Center of Oncology and Nuclear Medicine in the period from 2001 to 2021. The average age of patients was 47.86 ± 11.47 years. The ratio of men to women was 1:1. The continuous growth of high-grade glioma was detected in 125 cases. The progression of lowgrade glioma was observed in 40 patients. Transformation of low-grade glioma into high-grade glioma was found in 35 patients. Re-surgery was performed in 92 patients. Repeated radiation therapy was given to 140 patients. Chemotherapy as the method of choice was administered to 60 patients.Results. The median overall survival (OS) time was 36 months. The 1and 2-year survival rates were 96.0 % and 59.4 %, respectively. The method-specific overall survival time was 15 months. There was a tendency towards an increase in OS in all subgroups of patients who underwent re-surgery. The highest method-specific overall survival rates were observed in patients who received stereotactic radiation therapy (STRT) and combined photon-neutron therapy (CPNT): 23 and 47 months in patients with high-grade glioma and 60 and 72 months in patients with continuous growth of low-grade glioma, respectively (p>0.05). In patients with the transformation of low-grade glioma into high-grade glioma, the method-specific OS was higher in patients who received combination of chemotherapy and radiation therapy compared to those who received chemotherapy or radiation therapy alone: 32, 12, and 24 months, respectively (p>0.05).Conclusion. Repeated surgery is the optimal treatment approach for patients with continuous growth of primary brain glioma. In cases with repeated radiotherapy courses, CPNT or STRT can be the methods of choice. Treatment of patients with transformation of low-grade gliomas into high-grade gliomas should include repeated course of chemoradiotherapy.
Immune checkpoint inhibitors for the treatment of solid tumors in HIV-infected patients: is it worth the risk?
Authors: Degtiareva E. A. , Protsenko S. A. , Imyanitov E. N. 
Published: February 2023

Objective. To present the available data regarding the tolerance of immune checkpoint inhibitors (ICIs) in cancer patients with concurrent HIV.Material and Methods. A literature search was conducted in the electronic databases PubMed, Cochrane Library and UpToDate up to February 2022.Results. The article outlines the background and experience of using ICIs for the treatment of malignant tumors in patients with concomitant HIV infection.Conclusions. Until recently, the presence of chronic infections, including HIV infection, was one of the key contraindications for prescribing immunotherapy. However, the recent scientific publications demonstrate the efficacy and good tolerability of ICIs in cancer patients with concurrent HIV. Future prospective clinical trials will help to predetermine the potential of immunotherapy in clinical practice in this patients.