bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphine counteracts the effects of paclitaxel in triple-negative breast cancer cells
Authors: Sezer Gülay , Caner Armağan , Önal Müge Gülcihan , Cumaoğlu Ahmet 
Published: January 2023

Background & objectives:
Several studies have provided evidence that opioids may play a role in cancer recurrence and metastasis. Multiple research data indicate that morphine can act as a proliferative or suppressive agent on tumour cells depending on the applied concentration. Therefore, this study was aimed to investigate whether the presence of clinically relevant concentrations of morphine has any effect on the efficacy of paclitaxel, a widely used chemotherapeutic drug, on the viability and apoptosis of human triple-negative breast cancer cell line.

Methods:
MDA.MB.231 cells were treated with paclitaxel in the presence or absence of morphine and examined for cell proliferation by the MTT assay. In addition, the effect of morphine on paclitaxel-induced apoptosis was investigated by flow cytometric assay and by the ratio of Bax/Bcl-2 mRNA expression levels with quantitative real-time (qRT)-PCR.

Results:
Morphine significantly increased the proliferation of breast cancer cells at low concentrations (0.1-2.5 µM) but higher concentrations showed cytotoxic effect. Pre-treatment with 0.1 or 1 µM of morphine decreased the paclitaxel-induced cytotoxicity, the proportion of apoptotic cell, and the ratio of Bax/Bcl-2 mRNA expressions.

Interpretation & conclusions:
Our data suggest that morphine promotes breast cancer cell viability at clinically relevant plasma concentrations and reduces the apoptotic effect of paclitaxel. This interaction may be very important in clinical settings; however, more studies are needed to explore the plausible mechanisms of interaction and to correlate such findings through in vivo animal studies as well as clinically.
Role of Modified Sick Neonatal Score in Predicting the Neonatal Mortality at Limited-Resource Setting of Central India
Authors: Meshram Rajkumar Motiram , Nimsarkar Roshan A. , Nautiyal Ayushi P. 
Published: January 2023

Background:
The targets of Sustainable Development Goals cannot be achieved without reducing mortality of inborn as well as outborn neonates.

Objective:
The objective was to predict the mortality of neonates by applying Modified Sick Neonatal Score (MSNS).

Material and Methods:
Parameters of MSNS scoring system were applied to 450 neonates at the time of admission and followed up prospectively till discharge or death. The score and individual parameters were correlated with outcome. A receiver operating curve was plotted to determine the cutoff value for score to predict the mortality.

Results:
The common clinical diagnoses were respiratory distress (38%), sepsis (26%), and jaundice (14.44%). Sixty-two percent neonates were born at term and 38% were preterm while 55.56% neonates were low birth weight and 44.4% were weighted more than 2500 gms. Neonates who died were older at the time of admission, and duration of hospital stay was shorter compared to alive neonates (P < 0.001) with a mortality rate of 23.11%. The total MSNS for neonates who died was statistically significantly low, (mean ± standard deviation) 7.93 ± 2.70, compared to alive neonates, 12.02 ± 1.84 (P < 0.0001). With optimum cutoff score of ≤10, the sensitivity was 79.80% and the specificity was 82.37% while the positive predictive value and negative predictive value was 57.64% and 93.14% respectively with the area under curve was 0.89 (odds ratio-18.46, 95% confidence interval 10.3-33.64, P < 0.0001).

Conclusion:
The MSNS of ≤10 has a better sensitivity and specificity in predicting neonatal mortality and is easy to use with minimal resources to both preterm and term neonates.
Retrospective Validation of the Alexandria Retinopathy of Prematurity Model in Preterm Infants in Saudi Arabia
Authors: Raffa Lina H. , Akeely Omar M. , Alariefy Saleh A. , Alharbi Faisal A. , Alkhateeb Moussa A. , Khan Mohammad A. 
Published: January 2023

Background:
In developing countries, data on the applicability of existing models to predict retinopathy of prematurity (ROP) are scarce. The study aimed to validate the Alexandria ROP (Alex-ROP) and high-grade Alex-ROP (Hg Alex-ROP) models retrospectively to identify treatable ROP in a cohort of preterm infants in Saudi Arabia.

Materials and Methods:
We reviewed and included the records of 281 infants born prematurely in 2015–2021. We recorded the infants' demographics, gestational age at birth (GA), birth weight (BW), and serial weight measurements (day 7, 14, 21, and 28). We determined whether the included met the Alex-ROP and Hg Alex-ROP detection criteria for treatable or any-stage ROP and calculated the specificity, sensitivity, negative and positive predictive values, and accuracy.

Results:
The median BW and GA was 1095 g (range: 426–1920 g) and 29 weeks (range: 23–36 weeks), respectively. ROP developed in 112 infants, of which 30 cases were treatable. The Alex-ROP sensitivity for correctly predicting any-stage ROP and treatable ROP was 77.7% and 80.0%, respectively, and its specificity for predicting any-stage ROP and treatable ROP was 49.7% and 41%, respectively. The Hg Alex-ROP had 36.6% and 50.0% sensitivity for detecting any-stage ROP and treatable ROP, respectively, and its specificity for detecting any-stage ROP and treatable ROP was 83.4% and 78.5%, respectively.

Conclusion:
Previously published accuracy parameters were not reproducible in this cohort and a significant number of children requiring treatment would have been missed if the Alex-ROP or Hg Alex-ROP were applied.
Impact of a Short Period of Prone Versus Supine Nursing in Preterm Neonates Less Than 32 Weeks on Weight Gain
Authors: Venkatesh H. A. , Mohanty Pankaj Kumar 
Published: January 2023

Background:
Postnatal growth depends on multiple factors such as gestational age, associated morbidities, and the nutrition and varies from one newborn to another. Preterm babies in neonatal intensive care unit are very much susceptible to growth faltering even after adequate nutrition and supplements. The positioning of preterm infants in neonatal intensive care has an impact on their survival and neurological outcome. Prone positioning is known to improve oxygenation, minute ventilation, and functional residual capacity. Quiet undisturbed sleep in preterms has helped them to conserve energy for growth.

Objective:
To determine the effect of prone versus supine position on weight gain in infants less than 32 weeks of gestational age.

Design:
Prospective observational study.

Participants:
Twenty-two neonates were recruited. Results: On day 1, in the prone position, 63.6% gained weight vs. 59.1% in the supine position (P = 0.425). On day 2, in prone, 72.7% has gained vs. 63.6% in supine (P = 0.359). On day 3, in prone, 68.2% gained weight vs. 63.6% in supine position (P = 0.426).

Conclusion:
Nursing a baby in a prone position has demonstrated weight gain over nursing in a supine position though not statistically significant.
Delayed-Onset Urticaria Following Vaccination for COVID-19
Authors: Clark Brandon L. , Yentzer Brad A. 
Published: January 2023

Background:
As COVID-19 vaccines continue to be administered worldwide, there are an increasing number of studies documenting cutaneous reactions following vaccination. Systemic reactions, such as urticarial diseases, occur.

Purpose:
The main objective of this study was to investigate the association between urticaria and recent vaccination for COVID-19.

Methods:
A retrospective chart review examining the association of urticaria and COVID vaccination was conducted.

Results:
We report 17 patients who developed an urticarial reaction following vaccination against COVID and one patient who developed an urticarial reaction following a COVID infection. The vast majority of the patients were women with a mean age of 42.8 years.

Conclusion:
Cutaneous manifestations often follow COVID vaccination and infection. It may be helpful to inquire about recent infections and vaccinations in patients presenting with urticarial diseases.
Autologous Platelet-Rich Fibrin Membrane as a Wound Dressing in the Treatment of Chronic Nonhealing Leg Ulcers
Authors: Asfiya Amina , Sarvajnamurthy Sacchidanand , Shariff Fardeen , Budamakuntala Leelavathy 
Published: January 2023

Background:
Chronic nonhealing ulcers of the lower extremity are a cause of morbidity and mortality. The various treatment options available are limited and unsatisfactory. Promoting wound healing with an autologous platelet membrane could be a safe, easy, and inexpensive modality.

Purpose:
To assess an autologous platelet-rich fibrin (PRF) membrane as a wound dressing in the treatment of chronic nonhealing leg ulcers.

Methods:
A prospective study enrolled 30 patients with chronic nonhealing leg ulcers. Autologous PRF was applied weekly for 6 weeks. At each visit, the ulcer healing was assessed with wound measurements and photographs. The treatment outcome was defined as a percentage in a change of area and volume of the ulcer at the end of the study period.

Results:
Thirty patients with chronic nonhealing leg ulcers were treated for 6 weeks. 100% improvement in area of the ulcer was seen in 43% ulcers. The mean percentage of improvement in area of the ulcer was 72%. The mean percentage of improvement in volume of the ulcer was 77%. The mean duration of healing was 5 weeks.

Conclusion:
This study was limited by the lack of a control group. Autologous PRF may be useful for the treatment of chronic nonhealing leg ulcers which can be done on an outpatient basis with minimum adverse effects.
Serum versus tissue levels of FoxO3a, zinc, and iron in patients with vitiligo
Authors: Hofny Eman R.M. , Twisy Howida O. , Bamatraf Maysaa S. , Hasan Howayda I. , Mohamed Nahed A. , Mahran Ayman M. 
Published: January 2023

Background
Vitiligo is a pigmentation disorder characterized by milky white patches. It is caused by destruction of melanocytes because of an uncertain etiology. Oxidative stress (OS) hypothesis is highly considered in vitiligo pathogenesis. Antioxidants, including the Forkhead box O (FoxO) proteins, iron, zinc, and others, were found to be impaired in patients with vitiligo.

Objective
To assess the role of OS in the pathogenesis of vitiligo and to decide whether is it a local dysfunction, systemic process, or both.

Patients and methods
A case–control study was conducted, in which serum and tissue levels of FoxO3a, zinc, and iron were estimated in 50 patients with vitiligo and 30 age-matched and sex-matched healthy volunteers. FoxO3 levels were measured using ELISA kits. Iron and zinc levels were measured using colorimetric methods.

Results
No significant difference was found between serum FoxO3a levels in patients and controls (P=0.427), whereas lesional FoxO3a was significantly lower than its level in the skin of controls (P<0.001). Zinc and iron levels were significantly lower in serum and tissue of patients with vitiligo than in controls (P<0.001 for each).

Conclusion
Both serum and tissue levels of antioxidants are probably involved in the pathogenesis of vitiligo. However, tissue OS may be affected more. Some antioxidants, such as, zinc, may be involved more than others.
Assessment of serum levels of vitamin D and tissue levels of vitamin D receptors in acanthosis nigricans
Authors: El Tahlawy Samar , Bahaa Sara , Shaker Olfat , El Ghanam Omar , Diaa Mai 
Published: January 2023

Background
Acanthosis nigricans (AN) is a skin disorder characterized by symmetrical, thickened, dark plaques comprising hyperkeratosis and acanthosis. Vitamin D (VD) plays an important role in the regulation of skin proliferation and differentiation, and mediates its action by binding to specific vitamin D receptors (VDR) in the nuclei of target cells.

Objective
To measure the serum levels of VD and tissue levels of VDR in a group of Egyptian patients with AN in comparison to healthy controls, in order to shed more light on the possible relation between VD, VDR, and AN.

Patients and methods
This study included 25 AN patients and 25 age-matched and sex-matched healthy controls. Blood samples and skin biopsies were taken from all participants for the evaluation of serum VD, glucose, insulin, and tissue VDR levels.

Results
Serum VD and tissue VDR were significantly lower (P<0.001 for both), while serum insulin and homeostatic model for insulin resistance were significantly higher (P<0.001 and P=0.002, respectively) in patients than controls. Patients had a more deficient pattern of VD status than controls (P<0.001). There was a statistically significant positive correlation between serum VD and tissue VDR in patients (r=0.632, P=0.001).

Conclusion
The present study suggests a possible role for low serum VD and tissue VDR levels in causing AN, in genetically predisposed individuals.
Treatment of warts with intralesional immunotherapy
Authors: Omar Shaimaa I. , Ragab Magdy A. , Elneily Dalia A. , Shahin Marwa A. 
Published: January 2023

Background
Warts are skin disease caused by human papilloma virus infection and characterized by high rate of recurrence and resistance. The use of purified protein derivatives (PPD) for treatment of warts achieved good results, however, some patients do not respond to it. Deficiency of mannose-binding lectin (MBL) may be a risk for repeated viral infection.

Objective
To investigate the factors that may affect and predict the clinical response of warts to the treatment with PPD.

Patients and methods
This study was conducted on 50 patients with warts and 50 apparently healthy-control volunteers. Blood samples from all participants were investigated for the polymorphism in MBL2-gene exon-1 codon 54 by PCR before treatment. All patients were injected intralesionally in the biggest wart every 2 weeks for five sessions.

Results
About 56% of the patients achieved complete response, 8% attained partial response, and 36% did not show any response. We did not detect recurrence or progression during the follow-up period. There was significantly higher clinical response in patients with less than five warts and in those with warts of less than 1-year duration. There was significantly lower clinical response in patients with warts over the dorsum of hand, while higher clinical response was observed in the warts over the sole. Although higher number (48%) of patients compared with controls showed polymorphism of MBL2 gene, it has no relation of the effect of PPD injection.

Conclusion
Intralesional immunotherapy with PPD is effective and safe for treatment of warts. Duration, number, and site of warts might have an impact on the clinical response to PPD immunotherapy, while MBL2-gene exon-1 codon-54 polymorphism has no effect.
Gynaecological Complications in General Surgery Unit: A Single-Center Study
Authors: Bhatti Nadia , Bhatti Afshan , Bhatti Najia , Ali Muharram , Shaikh Aisha , Abro Abdul Sattar 
Published: January 2023

Introduction: This study aims to investigate the frequency of gynecological complications reported during emergency and elective general surgeries. Methodology: This is a cross-sectional study, data were collected retrospectively, approximately 500 patients went through surgical management in the general surgery department while only 125 reported associated issues requiring surgical management and required gynecological interventions. Data was entered & analyzed using SPSS version 22. Frequency and percentage were calculated for quantitative variables such as presenting complaints, reported gynecological issues, required intervention, and reported associated problems. Results: A total of 125 patients were enrolled in the study with the most commonly reported presenting complaint being pain with the vaginal discharge with vomiting documented in 72(57.5%) of patients. Puss discharge from wounds, peritonitis, and abdominal swelling were other frequently reported issues in 14(11.2%), 11 (8.7%), and 11 (8.7%) patients respectively. 98(78%) were discharged after successful management of gynecological as well as general surgical problems, 25(20%) were referred to tertiary care health care setup for more appropriate care and 1(1%) had a burst abdomen. Only 1 (1%) out of 125 patients expired during the study period. Conclusion: Gynecological complications have been markedly reported in the general surgery unit, necessitating general surgeons to intercede and deliver significant benefits in terms of lowering morbidity, mortality, postoperative complications, and length of hospital stay from a diagnostic and therapeutic point of view.
The Adopted Strategic Management Practices on Governance of LGAs in Tanzania
Authors: Pandisha Haghai , Kombe Wilbard , Kayunze Kim 
Published: January 2023

Purpose: Local Government Authorities are constantly implementing activities directed from central government by means of decentralization to enhance governance in resource allocation and service deliverance. This has made councils to engage in SMPs in order to continue and achieve their targeted goals. This study aims to explore Strategic Management Practices adopted by Local Government Authorities in Tanzania.
Methodology: The study adopted diagnostic survey design by taking into account all steps involved in survey studies to obtain important data concerning Strategic Management Practices adopted in Local Government Authorities. Both simple and purposive sampling were employed to determine the study sample of 351 staff council who participated in implementation of Strategic Management Practices. Questionnaire, interviews and Focus Group Discussions were used to collect the information from the respondents. Descriptive analysis was used to compute frequencies and percentage, while content analysis was used to analyze the main themes from key informants. The study selected Mufindi District Council as a case study to explore the Strategic Management Practices adopted.
Findings: Finding of the study found councils undertaking situational analysis, formulation of strategic plan and performance review. Furthermore, finding revealed that councils are equipped with different strategic models in developing strategic plan particularly SWOT analysis and balanced scorecard. It was further found that management, institutional and resource factors have significantly influenced the councils’ decision to adopt SMPs through strategic models.
Unique Contribution to Theory, Practice and Policy: The study recommends that successfully strategy implementation can be achieved when councils allocates all required resources with effective monitoring of the activities.
Quality of Life of Chronic Renal Failure Patients Undergoing Hemodialysis Therapy
Authors: Kartiko Utomo Endrat , Wahyudi Totok 
Published: January 2023

Background: Changes in lifestyle associated with the complex treatment of hemodialysis, which ultimately affects the mental or psychological and social of the patient. Changes in physical, psychological functioning, lack of mobility, work problems, unemployment in activities, fatigue and fear of future challenges are problems faced by people with chronic renal failure undergoing hemodialysis therapy. Objective: To determine the quality of life in chronic renal failure patients undergoing hemodialysis therapy. Method: Type of descriptive research using Analytical Survey with a total sample of 53 respondents taken with purposive sampling techniques and quality of life instruments measured with KDQOL-SF 3.6. Results: Average quality of life symptom/problem list 66.90, effect kidney disease 65.68, burden kidney disease 50.47, SF-12 Physical Health 40.69, and SF-12 Mental Health 50.20. Conclusion: The role of families and hospitals is able to improve and maintain the quality of life of chronic renal failure patients undergoing hemodialysis therapy.
Social Harmony in The Bedusun Sedakah Tradition at Belitang District Martapura Regebcy Indonesia
Authors: Syawaludin Mohammad 
Published: January 2023

The various regions of Indonesia certainly have cultures and traditions that are formed and passed down from generation to generation. All existing customs and practices have their own unique features and turn them into a feature of society. The diversity of customs is also an attraction, not only must be preserved, but existing are traditions also important to be introduced to a wider audience. A tradition that exists and is practiced in the culture of the South Sumatra region is sedakah bedusun . A tradition to express gratitude and purify the village from various trials and difficulties of life. This study aims to understand and interpret the social and religious values ​​contained in the tradition. This study uses a sociocultural approach and phenomenological type research while data collection techniques are increasingly advanced, namely observation, in-depth interviews in addition to documentation. Data analysis is used simultaneously through interpretation and contents. The results of this study indicate that traditions based on local wisdom have undergone a process of acculturation and acculturation. The meaning of this tradition is to invite the community at large to maintain harmony and make it a social bridge for many people. This is reflected in each traditional procession and its social significance.
Sistem Informasi Pendaftaran Praktek Kerja Nyata (PKN) dan Skripsi Fakultas Teknik Universitas Pancamarga
Authors: Ahmad Atijani , Hikmah Nuzul , Misdiyanto Misdiyanto 
Published: January 2023

A website is a collection of pages containing certain information and can be accessed easily by anyone, anytime, and anywhere through the internet. In an educational institution, of course, it is very necessary for information systems in regulating academic activities that are fast, effective, efficient, accurate to improve the quality standards of education in these educational institutions.
Faculty of Engineering, Panca Marga University is one of the private universities in Probolinggo Regency with 3 (three) study programs, namely electrical engineering, mechanical engineering and industrial engineering. Final projects such as Real Work Practice (PKN) and thesis are the final tasks that must be completed by a student who will graduate from the level of undergraduate education or diploma in college.
Currently, the final project administration process at the Faculty of Engineering, Panca Marga University is still computerized simply where the final task implementation data is still stored in folders made by academic staff themselves, there is no final project reporting system. This is felt inappropriate so it takes a long time to process the final project data with a large number of students. Based on this, researchers created a pkn final project information system and web-based thesis. In this study, the authors used the Waterfall Method as an application development method. The Waterfall method is a sequential development model. In the process of creating the waterfall method, it starts with analysis, design, coding, testing and maintenance