bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Mengelola Daftar Pustaka Menggunakan Referensi Mendeley untuk Mahasiswa STIKI Malang
Authors: Hadi Hilman Nuril 
Published: July 2023

Mendeley adalah salah satu perangkat lunak pengelola referensi yang dapat dimanfaatkan dalam menyusun daftar pustaka tugas akhir (TA) mahasiswa. Pemanfaatan Mendeley sangatlah penting bagi mahasiswa untuk menghindari plagiasi. Pelatihan pengelolaan daftar pustaka menggunakan Mendeley diharapkan dapat menjadi solusi permasalahan mahasiswa dalam penulisan TA. Kegiatan pelatihan dilaksanakan secara tatap muka dihadiri 29 mahasiswa STIKI Malang. Kegiatan pelatihan diawali dengan penyampaian pedoman TA yang memuat kode etik penelitian khususnya dalam penulisan daftar pustaka. Selanjutnya, penjelasan Mendeley sebagai salah satu perangkat lunak pengelola referensi baik secara teori maupun praktik. Kegiatan pelatihan ini berjalan dengan lancar diikuti oleh mahasiswa penempuh TA maupun mahasiswa yang belum menempuh TA. Mahasiswa antusias dengan mengikuti dari awal hingga akhir kegiatan serta berhasil menggunakan perangkat lunak Mendeley dalam mengelola referensi. Dengan adanya kegiatan ini diharapkan mampu menyelesaikan permasalahan pengelolaan referensi dalam penulisan TA di kalangan mahasiswa STIKI Malang.
Mendorong Penguatan Peran Dasa Wisma Melalui SAM GEPUN BASA di lingkungan Kelurahan Kebonsari Malang.
Authors: E Poerbaningtyas , P Diah Arifah 
Published: July 2023

Dasa Wisma adalah kelompok yang dibentuk dari 10 KK di lingkungan Rukun Tetengga (RT) yang memiliki peran dan tugas dalam mensejahterahkan masyarakat. SAM GEPUN BASA (Smart City Malang Gerakan Menghimpun Data Berbasis Masyarakat) merupakan aplikasi berbasis web yang dibangun oleh Pemerintah Daerah Kota Malang. Aplikasi ini dibangun untuk menghimpun data warga. Kegiatan pengabdian yang dilakukan adalah mendampingi masyarakat Dasa Wisma dalam mengisi aplikasi SAM GEPUN BASA tersebut khususnya warga RT 10 RW 01 Kelurahan Keonsari Kota Malang. Tujuan akhir dari kegiatan pendampingan ini adalah mendorong penguatan peran Dasa Wisma dalam menjalankan tugas di masyakarat.
МЕТОДИКА ПІДГОТОВКИ ПЕДАГОГІЧНИХ ПРАЦІВНИКІВ ЗАКЛАДІВ ПРОФЕСІЙНОЇ ОСВІТИ ДО ЗДІЙСНЕННЯ ЗМІШАНОГО НАВЧАННЯ В УМОВАХ ВІЙНИ
Authors: Єршова Ольга 
Published: July 2023

Війна є травмуючою подією, що викликає відчуття безпорадності й незахищеності, впливаючи на мислення людини та її ставлення до світу, спричиняючи хронічні стресові розлади. Участь в освітніх процесах набула нового емоційного забарвлення для усіх їх учасників. Це складне випробування і для педагогічних працівників, які, попри стрес та небезпеку, продовжують проводити заняття в он-лайн режимі, і для учнів, частина з яких змушені були покинути свої домівки. Розглянуті реалії здійснення он-лайн навчання здобувачів професійної освіти і запропоновані шляхи вирішення проблем.
Evaluation of Aus rice genotypes grown under rainfed and irrigated conditions
Authors: Alam MA , Islam AKMA , Karim MA , Ghosh UK , Khan MAR 
Published: July 2023

Bangladesh must keep increasing the production of rice (Oryza sativa L.), which is consumed by more than half of the world's population in order to ensure a steady supply of food for everyone. A field experiment was conducted to select short durated with high yield potential Aus rice genotypes under rainfed condition in a split plot design with three replications. Two water regimes (irrigated and rainfed) were imposed into main plot and 39 Aus rice genotypes were assigned into sub plots. In order to categorize the genotypes into various groups, multivariate studies including cluster analysis, principal component analysis (PCA), and discriminantfunction analysis (DFA) were carried out using fifteen quantitative plant traits. Results based on agronomic traits, the genotypes were grouped into six clusters. Early maturing genotypes are represented in cluster II, and genotypes with outstanding yield performance under irrigation are grouped in cluster III. Additionally, clusters III and IV indicate genotypes that mature quickly and a high yield potentiality under rainfed conditions, respectively. Biological yield played a very vital role under both irrigated and rainfed conditions. PCA revealed that PC 1, 2, 3, 4, and 5 described 84.90% variation under irrigated and 84.83% variation in rainfed condition, altogether. Stepwise DFA showed function 1 and 2 accounted for a cumulative of 95.40% of total variance in irrigated and of 92.3% variance in rainfed condition. BR24, Rupsail, Kachilon, Kachiloon2, Darial, Katak-Tara2, BRRI dhan43, Bowalia, BRRI dhan55 and BR14 showed the best performance under rainfed condition. The genotypes like Laksmilota, Loroi, Dhala Saita-3 and Kala manik can be used for further study as early maturing genotypes.
Ann. Bangladesh Agric. (2022) 26 (1) : 91-111
Role of Clinical Skill Centers in Undergraduate Dental Education: Stakeholders View
Authors: Hyder Md Liakat Ali , Talukder Md Humayan Kabir , Habib Md Ahsan , Alam Kazi Khairul , Rahman Ashiqur 
Published: July 2023

Background: The clinical skill center (CSC) offers an opportunity for students and working clinicians to learn and acquire clinical skills by using artificially simulated process, which will subsequently improve patient care and safety. To promote skill-based dental education, a CSC might be considered to incorporate in undergraduate dental education.
Objectives: To explore the views of the stakeholders about the role of clinical skill centers in undergraduate dental education. This study also identified the effect of clinical skill training in promoting and maintaining clinical teaching.
Method: A cross sectional study was carried out among 637 dental persons in 11 dental colleges and units of medical colleges of Bangladesh; of which 5 were government and 6 were non-government. Study period was from January 2022 to December 2022. Data was collected by structured self-administered questionnaire, about the views of the stake holders (Dental teachers, interns and students of 3rd and 4th phases of BDS course).
Results: With regard to advantages of CSC, 545 (80.4%) respondents agreed that CSC facilitate skill training before performing on real patient. More so, 544 (90.3%) respondents agreed that CSC increases scope of repeated practice, 360 (64.7%) respondents felt that CSC training helped in overcoming the resistance by the patients who were not interested to intervene them by the trainees and 531(88.5%) agreed that skill training in CSC will reduce medical error. Regarding limitations of CSC, 419 (69.6%) respondents opined that establishing and maintaining CSC are very costly. Total 548 (90.9%) respondents agreed that CSC requires formally trained trainer, 550 (91.6%) respondents felt that CSC needs formally trained supporting staffs, and 533 (89%) agreed that CSC requires well defined infrastructure.
Conclusion: The study strongly suggests stakeholder’s positive perspective towards learning clinical skills in CSC. Medical educators, policy makers and curriculum designers can use the results of this study to incorporate clinical skill center based learning in undergraduate curriculum and establish CSC to train and enhance students’ clinical skills and maintain patients’ safety.
Bangladesh Journal of Medical Education Vol.14(2) July 2023: 60-71
Toleransi Antar Umat Beragama Perspektif Maftuh Basyuni
Authors: Ifkar Muhayyan , Mawardi Mawardi 
Published: July 2023

This study aims to describe and analyze Maftuh Basyuni's thoughts on the concept of tolerance between religious communities. In addition, it represents the supporting and inhibiting factors of religious tolerance, according to Maftuh Basyuni. This research is library research (Library Research). The author performs steps of identification, collection, processing and assessment of existing data related to Interfaith Tolerance according to Maftuh Basyuni, both in the form of primary and secondary data. The results from this study: the concept of religious tolerance, according to Maftuh Basyuni, is dynamic because it is maintained from time to time which means attitudes and actions that do not allow the urge to differentiate between other groups, which then form an attitude of respect and respect for equality. Factors that support religious tolerance, according to Maftuh Basyuni, include cooperation among internal religious communities, between religious communities and between religious communities and the government. Meanwhile, the factors that hinder religious tolerance are some areas. It tends to be sensitive, related to houses of worship, easily provoked by shallow fanaticism, the emergence of sects and deviant teachings, and a lack of understanding of religious teachings and government regulations regarding spiritual life.
Antimicrobial Activity Test of Medicinal Plant Extract Using Antimicrobial Disc and Filter Paper
Authors: Hidayat Muhammad Taufiq , Koentjoro Maharani Pertiwi , Prasetyo Endry Nugroho 
Published: July 2023

Plant extracts contain secondary metabolites such as flavonoids and phenolic compounds with antibiotic activity. Antibiotic activity test can be done by using the Kirby-Bauer disc method which the antibiotic activity is indicated by the formation of a clear zone. This research was conducted using extracts of Moringa oleifera leaves and Opuntia cochenillifera cladode extracted using ethyl acetate as a solvent. Antibiotic activity test against Staphylococcus aureus bacteria was done in Mannitol Salt Agar and Luria Bertani Agar media. The Kirby-Bauer discs used are Antimicrobial Disc Oxoid® and Filter Paper. The results of this study show that the use of the Antimicrobial Disc Oxoid® and Filter Paper shows no statistical difference in clear zone results (t-value = 0,45; p-value = 0,655; with α = 95%). While the Clear Zone results on Mannitol Salt Agar gave better results than Luria Bertani Agar and were statistically significant (t-value = 2,46; p-value = 0,02; with α = 95%). These findings indicate that filter paper can be an inexpensive alternative for the antibiotic test with no significantly different result compared to commercial antibiotic disc. However, an antibiotic test against Staphylococcus aureus is better done on Mannitol Salt Agar (MSA) compared to Luria Bertani Agar (LBA).
Comparison of machine learning approaches for near-fall-detection with motion sensors
Authors: Hellmers Sandra , Krey Elias , Gashi Arber , Koschate Jessica , Schmidt Laura , Stuckenschneider Tim , Hein Andreas , Zieschang Tania 
Published: July 2023

IntroductionFalls are one of the most common causes of emergency hospital visits in older people. Early recognition of an increased fall risk, which can be indicated by the occurrence of near-falls, is important to initiate interventions.MethodsIn a study with 87 subjects we simulated near-fall events on a perturbation treadmill and recorded them with inertial measurement units (IMU) at seven different positions. We investigated different machine learning models for the near-fall detection including support vector machines, AdaBoost, convolutional neural networks, and bidirectional long short-term memory networks. Additionally, we analyzed the influence of the sensor position on the classification results.ResultsThe best results showed a DeepConvLSTM with an F1 score of 0.954 (precision 0.969, recall 0.942) at the sensor position “left wrist.”DiscussionSince these results were obtained in the laboratory, the next step is to evaluate the suitability of the classifiers in the field.
Pockets of promise: exploring innovation and complexity of remote ECEC service delivery in Australia
Authors: Adamson Elizabeth , Skattebol Jennifer 
Published: July 2023

IntroductionThe existing funding architectures for early childhood education and care (ECEC) services in Australia are incompatible with the needs of remote and First Nations communities. The Australian system relies on a market-based model for ECEC – characterized by demand-led funding mechanisms where funding flows to users to choose what service to use. This model is not viable or sustainable in remote and First Nations communities. In this paper, we ask what we can learn from alternative models of ECEC that serve remote, largely Indigenous communities.MethodsThis research is based on interviews with 10 key stakeholders. Potential participants were identified using three selection criteria which established their expertise in relation to: advocacy and experience in delivering ECEC services in remote locations (evident in relevant parliamentary reviews and inquiries), in-depth knowledge about First Nations perspectives about ECEC models, and broader understandings of the ECEC system in Australia. Three themes were explored in the interviews: (1) funding context (including impact of recent changes to Budget Based Funding, and role of philanthropy in the ECEC sector); (2) Quality and regulatory context (including workforce challenges and cultural considerations); and (3) Future research (including research gaps, opportunities, and considerations). The study design and analysis of data was guided by policy studies frameworks that advocate for collaboration and coordination among researchers and stakeholders in order to address complex problems.ResultsAnalysis of the interviews illuminated the complex structural and cultural elements shaping the design of, and access to, ECEC in remote communities. Stakeholders argued that the ECEC system should be universal in that it delivers services that meet the needs of young children and their families. This requires the development of a definition of ‘universality’ that enables communities to define their own ECEC needs and the types of services best suited to meet those needs. Stakeholders’ views about the importance of community-led design and delivery highlighted the need to align structural and cultural aspects of quality standards and workforce needs, and also to strengthen consultation with First Nations organisations to better understand community-specific solutions.DiscussionThe paper outlines the complexities and nuances of ECEC service delivery in remote communities. The findings are intended to foster discussion about current initiatives, challenges, and futures possibilities for ECEC in remote communities in Australia. These findings concur with other research that argues for community led service delivery and for stronger equity-based partnerships between First Nations and non-First Nations researchers and organizations.
Relationship between serum uric acid and estimated glomerular filtration rate in adolescents aged 12-19 years with different body mass indices: a cross-sectional study
Authors: Tian Qiuwei , He Caixia , Wang Zisai , Hun Marady , Fu Yi-Cheng , Zhao Mingyi , He Qingnan 
Published: July 2023

BackgroundGlobally, chronic kidney disease (CKD) is a growing public health concern. Serum uric acid (SUA) is an easily detectable and readily available biochemical indicator that has long been recognized as an independent risk factor for CKD. In addition, studies have indicated a potential relationship between SUA and body mass index (BMI). However, studies on the effect of SUA levels on the estimated glomerular filtration rate (eGFR) in adolescents with different BMIs are very rare.MethodsWeighted multiple regression analysis was used to estimate the independent relationship between SUA and log-transformed eGFR. Additionally, we used a weighted generalized additive model and smooth curve fitting to describe the nonlinear relationships in the subgroup analysis.ResultsFirst, SUA was negatively associated with log-transformed eGFR even after adjusting for all covariates (β=-0.0177, 95% CI: -0.0203-0.0151, P&lt;0.0001). Second, the results of the stratified analysis found that after adjusting for all covariates, the decrease in log-transformed eGFR due to changes in per SUA levels (Per 1, mg/dL increase) was elevated in female adolescents (β=-0.0177, 95% CI: -0.0216, -0.0138, P&lt;0.0001), adolescents aged 12-15 years (β=-0.0163, 95% CI: -0.0200, -0.0125, P&lt;0.0001) and black (β=-0.0199, 95% CI: -0.0251, -0.0148, P&lt;0.0001) adolescents. Furthermore, we found that adolescents with a higher BMI had higher SUA levels, and the effect of SUA on eGFR was significantly higher in underweight adolescents (β=-0.0386, 95% CI: (-0.0550, -0.0223), P&lt;0.0001).ConclusionSUA was negatively associated with the eGFR in adolescents aged 12-19 years. Furthermore, we found for the first time that SUA affects the eGFR differently in adolescents with different BMIs. This effect was particularly significant in underweight adolescents.
NR4A1 as a potential therapeutic target in colon adenocarcinoma: a computational analysis of immune infiltration and drug response
Authors: Li Mei , Zhang Zhongyi , Li Mingzhou , Chen Zhe , Tang Weizhu , Cheng Xiang 
Published: July 2023

Background: Colon adenocarcinoma (COAD) is a common malignancy with high morbidity and mortality rates. The immune system plays a crucial role in CRC development and progression, making it a potential therapeutic target. In this study, we analyzed transcriptomic data from CRC patients to investigate immune infiltration and identify potential therapeutic targets.Method and results: we used CIBERSORT to analyze the immune infiltration in COAD samples and found that the high infiltration of M2 macrophages and neutrophils was associated with poor prognosis. Next, we identified NR4A1 as a potential therapeutic target based on its protective effect in two predict models. Using cancer therapeutics response analysis, we found that high expression levels of NR4A1 were sensitive to OSI-930, a tyrosine kinase inhibitor with anti-tumor effects.Conclusion: Our findings suggest that targeting NR4A1 with OSI-930 may be a promising therapeutic strategy for COAD patients with high levels of immune infiltration. However, further studies are needed to investigate the clinical efficacy of this approach.
RSV replication modifies the XBP1s binding complex on the IRF1 upstream enhancer to potentiate the mucosal anti-viral response
Authors: Qiao Dianhua , Xu Xiaofang , Zhang Yueqing , Yang Jun , Brasier Allan R. 
Published: July 2023

IntroductionThe unfolded protein response (UPR) has emerged as an important signaling pathway mediating anti-viral defenses to Respiratory Syncytial Virus (RSV) infection. Earlier we found that RSV replication predominantly activates the evolutionarily conserved Inositol Requiring Enzyme 1α (IRE1α)-X-Box Binding Protein 1 spliced (XBP1s) arm of the Unfolded Protein Response (UPR) producing inflammation, metabolic adaptation and cellular plasticity, yet the mechanisms how the UPR potentiates inflammation are not well understood.MethodsTo understand this process better, we examined the genomic response integrating RNA-seq and Cleavage Under Targets and Release Using Nuclease (CUT&amp;RUN) analyses. These data were integrated with an RNA-seq analysis conducted on RSV-infected small airway cells ± an IRE1α RNAse inhibitor.ResultsWe identified RSV induced expression changes in ~3.2K genes; of these, 279 required IRE1α and were enriched in IL-10/cytokine signaling pathways. From this data set, we identify those genes directly under XBP1s control by CUT&amp;RUN. Although XBP1s binds to ~4.2 K high-confidence genomic binding sites, surprisingly only a small subset of IL10/cytokine signaling genes are directly bound. We further apply CUT&amp;RUN to find that RSV infection enhances XBP1s loading on 786 genomic sites enriched in AP1/Fra-1, RELA and SP1 binding sites. These control a subset of cytokine regulatory factor genes including IFN response factor 1 (IRF1), CSF2, NFKB1A and DUSP10. Focusing on the downstream role of IRF1, selective knockdown (KD) and overexpression experiments demonstrate IRF1 induction controls type I and -III interferon (IFN) and IFN-stimulated gene (ISG) expression, demonstrating that ISG are indirectly regulated by XBP1 through IRF1 transactivation. Examining the mechanism of IRF1 activation, we observe that XBP1s directly binds a 5’ enhancer sequence whose XBP1s loading is increased by RSV. The functional requirement for the enhancer is demonstrated by targeting a dCas9-KRAB silencer, reducing IRF1 activation. Chromatin immunoprecipitation shows that XBP1 is required, but not sufficient, for RSV-induced recruitment of activated phospho-Ser2 Pol II to the enhancer.DiscussionWe conclude that XBP1s is a direct activator of a core subset of IFN and cytokine regulatory genes in response to RSV. Of these IRF1 is upstream of the type III IFN and ISG response. We find that RSV modulates the XBP1s binding complex on the IRF1 5’ enhancer whose activation is required for IRF1 expression. These findings provide novel insight into how the IRE1α-XBP1s pathway potentiates airway mucosal anti-viral responses.
The development, validation, and in vivo testing of a high-precision bronchial epithelial lining fluid sampling device
Authors: Gupta Akash , Burgess Janette K. , Slebos Dirk-Jan , Pouwels Simon D. 
Published: July 2023

IntroductionAnalysis of respiratory biomarkers or pharmaceutical drug concentrations in bronchial epithelial lining fluid (bELF) using a high-precision sampling method is crucial for effective clinical respiratory diagnostics and research. Here, we utilized a cellulose matrix as an absorptive probe for bELF sampling, subsequently testing the design of a device and sampling technique in vivo.MethodsThe absorptive matrix [Whatman® qualitative filter paper (Grade CF-12)] was first tested through tissue-contact experiments on porcine airway tissue. The absorption and elution capacity of the matrix, as well as the laboratory processing and analysis method, was validated with a range of Interleukin-8 (CXCL8) and C-Reactive protein (CRP) stock solutions. Subsequently, the device’s design was optimized for universal in-house production and both, safe and efficient sampling. The airway sampling method was then tested in a group of 10 patients with Chronic Obstructive Pulmonary Disease (COPD). For each patient, a bELF sample was obtained using the newly developed bELF probe, as well as a reference 20 mL saline bronchial wash sample. Supernatants were assessed, using an immunoassay, for levels of the pro-inflammatory markers CXCL8, Myeloperoxidase (MPO), and CRP. The bELF samples were compared to bronchial wash.ResultsThe Whatman® qualitative filter paper (Grade CF-12) bELF probes adhered to porcine airway tissue, softening slightly upon wetting. The material maintained architectural integrity following the removal of the probes, leaving no residual fibers on the porcine airway mucosa. The bELF probe design was optimized for bronchoscopic delivery and in-house production. On average, a fully saturated bELF probe carried 32 μL of protein-rich fluid. The mean return of CXCL8 and CRP from samples collected from a serial dilution series (1, 5, 10, 20 ng/mL) was 69% (range 48%–87%). The bELF probe detected, on average, 7 (MPO), 14 (CRP), and 59 (CXCL8) times higher equivalent inflammatory protein concentrations in the collected bELF probe samples compared to the bronchial wash.ConclusionThe bELF probe is an effective absorptive technology for high-precision bELF sampling without dilution. With a simple in-house production procedure and bronchoscopic sampling technique, this method can be introduced in any bronchoscopic center for a consistent sampling of bELF.