bluuebunny/crossref_metadata_2025_split huggingface dataset:
American prejudice during the COVID-19 pandemic
Authors: Huber Christina , Brietzke Sasha , Inagaki Tristen K. , Meyer Meghan L. 
Published: December 2022

AbstractIn the United States, anti-Asian sentiment has pervaded the Coronavirus 2019 (COVID-19) pandemic. Could Americans’ fear of contracting the virus relate to prejudice against Asian individuals? According to intergroup threat theory, prejudice increases toward groups of people when they are perceived as a likely cause of symbolic and/or real threat, including disease threat. We tested this perspective in the context of the COVID-19 pandemic by investigating the relationship between Americans’ concern about contracting COVID-19 and their feelings toward individuals from multiple countries. Between May 12–14 2020, participants residing in the United States (N = 932) completed an online survey assessing their (1) perceived threat of COVID-19 infection, (2) feelings of warmth and coldness toward people in America, China, Italy, Japan, and Greece, and (3) trait-level prejudice. Perceived threat of COVID-19 infection differentially related to feelings toward American and Chinese nationals and was unrelated to feelings toward people from other countries assessed. Specifically, greater threat of infection was associated with less warmth toward individuals from China, an effect moderated by trait-level prejudice. That is, participants high (but not medium or low) in trait prejudice showed a significant relationship between threat of COVID-19 infection and reduced warmth toward Chinese individuals. Threat of infection also related to greater warmth and less coldness toward American nationals, consistent with prior work indicating that disease threats amplify ethnocentrism. Collectively, results suggest that perceived threat of COVID-19 infection may correspond with prejudice toward the national outgroup associated with the disease’s origin (i.e., China), as well as national ingroup favoritism, among Americans prone to prejudice.
Sacral neuromodulation for overactive bladder using the InterStim and BetterStim systems
Authors: Meng Lingfeng , Tian Zijian , Zhang Yaoguang , Wang Jianye , Liao Limin , Chen Guoqing , Tian Xiaojun , Ma Lulin , Li Yan , Shi Benkang , Zhang Yong , Ling Qing , Zhang Peng , Wei Zhongqing , Zhong Tie , Xu Zhihui , Li Jiayi , Luo Deyi 
Published: December 2022

AbstractThis study aimed to evaluate differences in the clinical outcomes of different sacral neuromodulation systems (InterStim and BetterStim) used in the treatment of overactive bladder. Data from a previously established database of sacral neuromodulation in China (the InterStim system) and a 2020 clinical trial of the BetterStim system were screened. Patients with overactive bladder undergoing stage II implanted pulse generator implantation were selected for analysis and divided into InterStim and BetterStim system groups. Voiding diaries and subjective scores obtained preoperatively, after stage I tined-lead implantation (experience period), and after stage II implanted pulse generator implantation were compared between the two groups. This study included 113 patients with overactive bladder (43, InterStim system group; 70, BetterStim system group). Voiding diaries and subjective scores significantly improved in both the InterStim and BetterStim system groups over the treatment period. Specifically, the urination frequency (all P < 0.001), average voiding volume (all P < 0.001), and average urinary leakage (InterStim, P < 0.05; BetterStim, P < 0.01) in both groups significantly improved at different periods during treatment. At the same time, the urgency perception scale (P < 0.001) and OAB-related quality of life score (InterStim, P < 0.05; BetterStim, P < 0.01) also significantly improved. There was no significant difference in urination frequency at baseline between the two groups (P = 0.169). Urination frequency was significantly higher in the BetterStim system group than in the InterStim group during the experience period and at follow-up (P = 0.031, P = 0.006). There was no significant difference in the number of urinary leakages between the different systems at baseline (P = 0.662), although this was higher in the InterStim system group during the experience period (P = 0.016), and the difference disappeared at the last follow-up (P = 0.565). There were significant differences in baseline urgency perception scale (P = 0.001) and OAB-related quality of life score (P < 0.001) between the two groups; however, these differences were not maintained at follow-up (P = 0.81, P = 0.479). Both sacral neuromodulation systems are safe and effective in treating overactive bladder. The InterStim system may be more beneficial for patients with dry overactive bladder. Satisfactory outcomes may be achieved with the BetterStim system in patients with wet overactive bladder. However, further studies are required to confirm this finding.
Automatic generation of structural geometric digital twins from point clouds
Authors: Mirzaei Kaveh , Arashpour Mehrdad , Asadi Ehsan , Masoumi Hossein , Li Heng 
Published: December 2022

AbstractA geometric digital twin (gDT) model capable of leveraging acquired 3D geometric data plays a vital role in digitizing the process of structural health monitoring. This study presents a framework for generating and updating digital twins of existing buildings by inferring semantic information from as-is point clouds (gDT’s data) acquired regularly from laser scanners (gDT’s connection). The information is stored in updatable Building Information Models (BIMs) as gDT’s virtual model, and dimensional outputs are extracted for structural health monitoring (gDT’s service) of different structural members and shapes (gDT’s physical part). First, geometric information, including position and section shape, is obtained from the acquired point cloud using domain-specific contextual knowledge and supervised classification. Then, structural members’ function and section family type is inferred from geometric information. Finally, a BIM is automatically generated or updated as the virtual model of an existing facility and incorporated within the gDT for structural health monitoring. Experiments on real-world construction data are performed to illustrate the efficiency and precision of the proposed model for creating as-is gDT of building structural members.
Social mobility across the lifecourse and DNA methylation age acceleration in adults in the UK
Authors: Bao Yanchun , Gorrie-Stone Tyler , Hannon Eilis , Hughes Amanda , Andrayas Alexandria , Neilson Grant , Burrage Joe , Mill Jonathon , Schalkwyk Leonard , Kumari Meena 
Published: December 2022

AbstractDisadvantaged socio-economic position (SEP) is associated with greater biological age, relative to chronological age, measured by DNA methylation (positive ‘age acceleration’, AA). Social mobility has been proposed to ameliorate health inequalities. This study aimed to understand the association of social mobility with positive AA. Diagonal reference modelling and ordinary least square regression techniques were applied to explore social mobility and four measures of age acceleration (first-generation: ‘Horvath’, ‘Hannum’ and second-generation: ‘Phenoage’, DunedinPoAm) in n = 3140 participants of the UK Household Longitudinal Study. Disadvantaged SEP in early life is associated with positive AA for three (Hannum, Phenoage and DunedinPoAm) of the four measures examined while the second generation biomarkers are associated with SEP in adulthood (p < 0.01). Social mobility was associated with AA measured with Hannum only such that compared to no mobility, upward mobility was associated with greater age independently of origin and destination SEP. Compared to continuously advantaged groups, downward mobility was associated with positive Phenoage (1.06y [− 0.03, 2.14]) and DunedinPoAm assessed AA (0.96y [0.24, 1.68]). For these two measures, upward mobility was associated with negative AA (Phenoage, − 0.65y [− 1.30, − 0.002]; DunedinPoAm, − 0.96y [− 1.47, − 0.46]) compared to continually disadvantaged groups. While we find some support for three models of lifecourse epidemiology with early life as a sensitive period, SEP across the lifecourse and social mobility for age acceleration measured with DNA methylation, our findings suggest that disadvantaged SEP across the lifecourse is most consistently associated with positive AA.
Messenger RNA in lipid nanoparticles rescues HEK 293 cells from lipid-induced mitochondrial dysfunction as studied by real time pulse chase NMR, RTPC-NMR, spectroscopy
Authors: Sciolino Nicholas , Reverdatto Sergey , Premo Aaron , Breindel Leonard , Yu Jianchao , Theophall Gregory , Burz David S. , Liu Anna , Sulchek Todd , Schmidt Ann Marie , Ramasamy Ravichandran , Shekhtman Alexander 
Published: December 2022

AbstractAnalytical tools to study cell physiology are critical for optimizing drug-host interactions. Real time pulse chase NMR spectroscopy, RTPC-NMR, was introduced to monitor the kinetics of metabolite production in HEK 293T cells treated with COVID-19 vaccine-like lipid nanoparticles, LNPs, with and without mRNA. Kinetic flux parameters were resolved for the incorporation of isotopic label into metabolites and clearance of labeled metabolites from the cells. Changes in the characteristic times for alanine production implicated mitochondrial dysfunction as a consequence of treating the cells with lipid nanoparticles, LNPs. Mitochondrial dysfunction was largely abated by inclusion of mRNA in the LNPs, the presence of which increased the size and uniformity of the LNPs. The methodology is applicable to all cultured cells.
Comprehensive effects of interdecadal change of sea surface temperature increase in the Indo-Pacific Ocean on the warming-wetting of the Qinghai–Tibet Plateau
Authors: Dong Na , Xu Xiangde , Cai Wenyue , Zhao Tianliang , Sun Chan 
Published: December 2022

AbstractThe correlation characteristics between anomalous changes in summer precipitation on the Qinghai–Tibet Plateau (QTP) and the high-impact areas of global sea-surface temperature (SST) are mainly studied in this paper. The results show that the interdecadal change of the regional “warming-wetting” in China is especially prominent in the northern part of the main body of the QTP, which is therefore identified as the high-value area of precipitation variability. Investigations have revealed that the high-value areas of summer precipitation variability in the northern QTP are significantly correlated with four high-value areas of SST variability, namely the western North Pacific, the western Central Pacific, the Southwest Pacific, and the central Indian Ocean. In these four high-impact areas, a synchronous tendency is found in the SST increase and sea-surface specific humidity. Through the tracking analysis of the correlated vectors of the water vapor source for the warming-wetting of the QTP, it further confirms that the four high-value areas of SST variability in the Indo-Pacific Ocean are the major impact sources of water vapor transport for the warming-wetting of the QTP. Moreover, the comparison of the characteristics of various interdecadal global water vapor transport circulations show that from 1991 to 2020, the trans-equatorial water vapor transport from the Southern Hemisphere witnessed a notable increase, which furthermore suggests that the interdecadal change of SST increase in the Southwest Pacific and central Indian Ocean is the key reason for the warming-wetting of the QTP. In addition, a comprehensive image of high-impact marine water vapor sources for modulating the warming-wetting tendency in the QTP is proposed.
Prediction of optical coherence tomography-detected calcified nodules using coronary computed tomography angiography
Authors: Sugiura Junichi , Watanabe Makoto , Nobuta Saki , Okamura Akihiko , Kyodo Atsushi , Nakamura Takuya , Nogi Kazutaka , Ishihara Satomi , Hashimoto Yukihiro , Ueda Tomoya , Seno Ayako , Onoue Kenji , Soeda Tsunenari , Saito Yoshihiko 
Published: December 2022

AbstractDiagnosis of calcified nodules (CNs) is critical in the proper management of coronary artery disease, but CNs can be detected only using intracoronary imaging modalities. This study aimed to investigate the ability of coronary computed tomography angiography (CCTA) in predicting CNs detected using optical coherence tomography (OCT). From 138 patients who underwent OCT-guided percutaneous coronary intervention (PCI) after CCTA evaluation, 141 PCI target vessels were retrospectively enrolled and classified into CN (12 vessels/11 patients; CNs in the PCI culprit lesion) and non-CN (129 vessels/127 patients; without CNs) groups based on the OCT analysis. Retrospective CCTA analysis revealed significantly higher coronary artery calcification score (CACS), calcified plaque volume (CPV), and maximum calcified plaque area (MCPA) of the target vessel in the CN group than in the non-CN group. Receiver operating characteristic curve indicated that CACS ≥ 162 (area under the ROC curve (AUC 0.76, sensitivity 83.3%, specificity 54.2%), CPV ≥ 20.1 mm3 (AUC 0.83, sensitivity 100%, specificity 57.3%), and MCPA ≥ 4.51 mm2 (AUC 0.87, sensitivity 91.7%, specificity 78.3%) were the best cutoff values for predicting CNs. MCPA showed the highest AUC among all the CCTA parameters. In conclusion, CCTA is useful for predicting OCT-detected CNs in PCI target vessels.
Overlapping states of AWGS muscle dysfunction and inverse feasibility of ADL recovery by rehabilitation in older inpatients
Authors: Yamashita Masashi , Obata Hiroaki , Kamiya Kentaro , Matsunaga Atsuhiko , Hotta Kazuki , Izumi Tohru 
Published: December 2022

AbstractRehabilitation based on guided walking is effective to recover activity of daily living (ADL) in frail older adults, even octogenarians. However, muscle dysfunction obviously reflects disability, and few studies have focused on ADL recovery by rehabilitation. We employed the state of muscle dysfunctions proposed by the Asian Working Group for Sarcopenia (AWGS) in 2019 and attempted to clarify the relation between the overlapping dysfunctions and the feasibility of ADL recovery after rehabilitation. In total, 297 frail older patients (the mean age: 82.8 years, 46.1% of patients were male) participated in a walking-guided rehabilitation program to achieve the goal of ambulatory discharge. Muscle dysfunction was categorized by four standardized methods at the start of rehabilitation (grip strength, gait speed, time of five sit-to-stand, and short physical performance battery: SPPB), according to the AWGS proposal. ADLs were monitored by Barthel index before admission, at the start of rehabilitation, and at discharge. At least one dysfunction was present in 95.3% of patients. If a single patient had three or more muscle dysfunction, the ADLs recovery was significantly limited (interaction: p < 0.05). The overlapped counts of AWGS muscle dysfunction helps to predict inverse feasibility of ADL recovery in frail older patients through rehabilitation.
Geochemical signatures of sedimentary and diagenetic processes in the trace fossil Rosselia from the Pliocene in Taiwan
Authors: Liou Yu‑Hsuan , Löwemark Ludvig , Wang Pei-Ling , Dashtgard Shahin 
Published: December 2022

AbstractTrace fossils are structures left in a substrate as the result of the activities of living organisms. The producer of the spindle-shaped trace fossil Rosselia incorporates fine-grained organic rich material into concentric layers surrounding the central shaft. Because Rosselia is common in stressed shallow marine environments where the preservation potential of organic material is generally poor, these trace fossils may act as natural archives, recording changes in the provenance of organic material. Carbon isotope values of organic carbon preserved in laminae of the studied Rosselia typically lie around − 26‰, suggesting a primary terrestrial source. However, increased levels of S and Ca detected from XRF scanning of the laminae indicate that at least some marine material is incorporated. Examination of a diagenetically altered specimen also demonstrates that both elemental composition and δ13C values can be substantially altered diagenesis. Nevertheless, the long stratigraphic range of Rosselia, from the Cambrian to the Present, and its ubiquitous occurrence in stressed shallow-marine settings make it a potentially powerful tool to reconstruct variations in the input of organic material in settings otherwise devoid of fine-grained organic matter.
A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture
Authors: Ho Wen-Jin , Kobayashi Mako , Murata Kozue , Hashimoto Yoshihide , Izumi Kenji , Kimura Tsuyoshi , Kanemitsu Hideo , Yamazaki Kazuhiro , Ikeda Tadashi , Minatoya Kenji , Kishida Akio , Masumoto Hidetoshi 
Published: December 2022

AbstractDecellularized xenogeneic vascular grafts can be used in revascularization surgeries. We have developed decellularization methods using high hydrostatic pressure (HHP), which preserves the extracellular structure. Here, we attempted ex vivo endothelialization of HHP-decellularized xenogeneic tissues using human endothelial cells (ECs) to prevent clot formation against human blood. Slices of porcine aortic endothelium were decellularized using HHP and coated with gelatin. Human umbilical vein ECs were directly seeded and cultured under dynamic flow or static conditions for 14 days. Dynamic flow cultures tend to demonstrate higher cell coverage. We then coated the tissues with the E8 fragment of human laminin-411 (hL411), which has high affinity for ECs, and found that Dynamic/hL411showed high area coverage, almost reaching 100% (Dynamic/Gelatin vs Dynamic/hL411; 58.7 ± 11.4 vs 97.5 ± 1.9%, P = 0.0017). Immunostaining revealed sufficient endothelial cell coverage as a single cell layer in Dynamic/hL411. A clot formation assay using human whole blood showed low clot formation in Dynamic/hL411, almost similar to that in the negative control, polytetrafluoroethylene. Surface modification of HHP-decellularized xenogeneic endothelial tissues combined with dynamic culture achieved sufficient ex vivo endothelialization along with prevention of clot formation, indicating their potential for clinical use as vascular grafts in the future.
Nematicidal activity of sweet annie and garden cress nano-formulations and their impact on the vegetative growth and fruit quality of tomato plants
Authors: Mohammad Ayman A. , Amer Heba M. , El-Sawy Sameh M. , Youssef Dalia A. , Nour Shaimaa A. , Soliman Gaziea M. 
Published: December 2022

AbstractRoot-knot nematode is one of the major problems that face the agricultural production of several vegetable crops. Chemical nematicides have been banned because of their healthy and environmental undesirable attributes. So, this study aimed to evaluate the potential use of sweet annie (Artimisia annua) and garden cress (Lepidium sativum) as green routes for the development of effective and eco-friendly alternative nematicides. Nematicidal activity of sweet annie and garden cress aqueous extracts (500 g/L) in the original and nano-forms were evaluated againstMeloidogyne incognitain tomato planted in infected soil under greenhouse conditions. Nineteen phenolic compounds were identified inA. annuaextract, which was dominated by chlorogenic acid (5059 µg/100 mL), while 11 compounds were identified inL. sativumextract, that dominated byp-hydroxybenzoic acid (3206 μg/100 mL). Nano-particles were characterized with smooth surface, spherical shape and small size (50–100 nm). Under laboratory, the nano-formulations showed mortality percentage ofM. incognitaJ2greater than the original extract from. Vegetative growth parameters of tomato plants treated withA. annuaandL. sativumextracts significantly improved compared to the control plants. Also, biochemical analysis revealed that the extracts were able to induce tomato plants towards the accumulation of phenolic compounds and increasing the activity of defensive enzymes (protease, polyphenol oxidase and chitinase) resulting in systemic resistance. Regarding tomato fruits yield and quality, the studied treatments significantly improved the yield and physicochemical parameters of tomato fruits in terms of fruit weight, diameter, TSS, pH, lycopene content and color attributes gaining higher sensorial acceptance by the panelist. Generally, both extracts represent promising nematicide alternatives and have potential use in crop management. The nano-form ofA. annuaextract outperformed the nematicidal activity of other studied treatments.
Circuit quantum electrodynamics with dressed states of a superconducting artificial atom
Authors: Chang Yu-Han , Dubyna Dmytro , Chien Wei-Chen , Chen Chien-Han , Wu Cen-Shawn , Kuo Watson 
Published: December 2022

AbstractA dynamical control of the coupling strengths between dressed states and probe photon states is demonstrated with a transmon-like artificial atom coupled to two closely spaced resonant modes. When the atom is driven with one mode, the atom state and driving photon states form the so-called dressed states. Dressed states with sideband index up to 3 were prepared and probed via the strong coupling to the other resonant mode. Spectroscopy reveals that the coupling strengths are “dressed” and can be modulated by the power and sideband index of the driving. The transmission of the probe tone is modulated by the driving microwave amplitude with a Bessel behavior, displaying multi-photon process associated with the inter-atomic level transitions.
Relaxin-2 plasma levels in atrial fibrillation are linked to inflammation and oxidative stress markers
Authors: Aragón-Herrera Alana , Couselo-Seijas Marinela , Feijóo-Bandín Sandra , Anido-Varela Laura , Moraña-Fernández Sandra , Tarazón Estefanía , Roselló-Lletí Esther , Portolés Manuel , Martínez-Sande José Luis , García-Seara Javier , Álvarez Ezequiel , González-Juanatey José Ramón , Rodríguez-Mañero Moisés , Eiras Sonia , Lago Francisca 
Published: December 2022

AbstractRelaxin-2 exerts many favourable cardiovascular effects in pathological circumstances such as atrial fibrillation (AF) and heart failure, but the mechanisms underlying its actions are not completely understood. Since inflammation and fibrosis are pivotal processes in the pathogenesis of AF, our aim was to study the relationship between relaxin-2 plasma levels in left atrium (LA) and peripheral vein with molecules implicated in fibrosis, inflammation and oxidative stress in AF patients, and to evaluate the anti-fibrotic ability of relaxin-2 in normal human atrial cardiac fibroblasts (NHCF-A). Peripheral vein relaxin-2 plasma levels were higher than LA relaxin-2 plasma levels in men while, in women, peripheral vein relaxin-2 levels were increased compared to men. AF patients with higher levels of relaxin-2 exhibited a reduction in H2O2 plasma levels and in mRNA levels of alpha-defensin 3 (DEFA3) and IL-6 in leucocytes from LA plasma. Relaxin-2-in-vitro treatment inhibited NHCF-A migration and decreased mRNA and protein levels of the pro-fibrotic molecule transforming growth factor-β1 (TGF-β1). Our results support an association between relaxin-2 and molecules involved in fibrosis, inflammation and oxidative stress in AF patients, and reinforce an anti-fibrotic protective role of this hormone in NHCF-A; strengthening the relevance of relaxin-2 in AF physiopathology, diagnosis and treatment.