bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why Is There a Range in Time Returning to Preoperative Activity Habits After Femoroacetabular Impingement Treatment in Recreational Athletes?
Authors: Wirries Nils , Ezechieli Marco , Schwarze Michael , Derksen Alexander , Budde Stefan , Ribas Manuel , Windhagen Henning , Floerkemeier Thilo 
Published: December 2022

Context: Professional athletes showed excellent results after hip preserving procedures. However, there is still a lack of knowledge regarding the rate of return to activity and the rehabilitation time of recreational athletes. Thus, the aim of this study was to investigate factors that were associated with an extended return-to-activity time in nonprofessional athletes. Design: Retrospective, quantitative case–control study. Methods: This study included 47 cases (45 nonprofessional athletes), which were divided according to return-to-activity time (short term: 0.0–7.0 mo vs long term: >7.0 mo). The clinical outcome were evaluated with the modified Harris hip score, the nonarthritic hip score, the Western Ontario and McMaster Universities Osteoarthritis Index, and the University of California, Los Angeles activity score. For statistical analysis between both groups, an unpaired student t test and a paired Wilcoxon test were used. In addition, the sports behavior, intraoperative findings, and surgical procedures were also assessed. Results: After a mean follow-up of 4.3 years (±0.6; 3.4–5.6), the overall postoperative modified Harris hip score was 81.8 points, the nonarthritic hip score was 75.8 points, the Western Ontario and McMaster Universities Osteoarthritis Index was 36.7 points, and the University of California, Los Angeles activity score was 7.9. Compared with the preoperative results, all scores improved significantly (P < .001). Patients of the short-term return-to-activity group showed a higher preoperative activity diversity and, postoperatively, a higher rate in high-impact sports (P = .024). Conclusions: After mini-open arthrotomy for femoroacetabular impingement syndrome treatment, 92.5% of the recreational athletes returned to sports activity. The findings did not detect factors influencing the return-to-activity time. However, a higher preoperative diversity of activities and a shift to high-level impact sport activities might support a shorter rehabilitation.
Genetic diagnosis of Duchenne and Becker muscular dystrophy through mRNA analysis: new splicing events
Authors: Segarra-Casas Alba , Domínguez-González Cristina , Hernández-Laín Aurelio , Sanchez-Calvin Maria Teresa , Camacho Ana , Rivas Eloy , Campo-Barasoain Andrea , Madruga Marcos , Ortez Carlos , Natera-de Benito Daniel , Nascimento Andrés , Codina Anna , Rodriguez Maria Jose , Gallano Pia , Gonzalez-Quereda Lidia 
Published: December 2022

BackgroundUp to 7% of patients with Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD) remain genetically undiagnosed after routine genetic testing. These patients are thought to carry deep intronic variants, structural variants or splicing alterations not detected through multiplex ligation-dependent probe amplification or exome sequencing.MethodsRNA was extracted from seven muscle biopsy samples of patients with genetically undiagnosed DMD/BMD after routine genetic diagnosis. RT-PCR of theDMDgene was performed to detect the presence of alternative transcripts. Droplet digital PCR and whole-genome sequencing were also performed in some patients.ResultsWe identified an alteration in the mRNA level in all the patients. We detected three pseudoexons inDMDcaused by deep intronic variants, two of them not previously reported. We also identified a chromosomal rearrangement between Xp21.2 and 8p22. Furthermore, we detected three exon skipping events with unclear pathogenicity.ConclusionThese findings indicate that mRNA analysis of theDMDgene is a valuable tool to reach a precise genetic diagnosis in patients with a clinical and anatomopathological suspicion of dystrophinopathy that remain genetically undiagnosed after routine genetic testing.
Enhancing catalytic activity of V2O5/TiO2 in H2S selective oxidation by modulating oxygen adsorption conditions
Authors: Lee Hyun Soo , Yang Jae Hwan 
Published: December 2022

This paper aimed to reveal the effects of chemisorbed oxygen species on selective catalytic oxidation applied for H2S removal. A sequence of thermal treatments were conducted on V2O5/TiO2 samples to prepare catalysts that possess different distributions of oxygen species. Characterization by X-ray photoelectron spectroscopy enabled a distinction among three different chemisorbed oxygen species: O–, O22–, and O2–. In addition, the dominance of the O– species, which is a very reactive oxygen species for catalytic oxidation reactions, was observed when the catalyst was exposed to 5% O2/N2 gas at the low temperature of 30 °C. It was also found that the N400A30 with the highest ratio of O– species was superior to others at converting H2S into elemental sulfur over the whole range of temperatures: the best S yield of N400A30 was 85% at 130 °C. These results are promising, as thermal treatments for oxygen adsorption were adopted for the first time to improve the catalytic activity of H2S removal by modulating the proportion of highly reactive O– species.
Partial Network Partitioning
Authors: Alkhatib Basil , Udayashankar Sreeharsha , Qunaibi Sara , Alquraan Ahmed , Alfatafta Mohammed , Al-Manasrah Wael , Depoutovitch Alex , Al-Kiswany Samer 
Published: December 2022

We present an extensive study focused on partial network partitioning. Partial network partitions disrupt the communication between some but not all nodes in a cluster. First, we conduct a comprehensive study of system failures caused by this fault in 13 popular systems. Our study reveals that the studied failures are catastrophic (e.g., lead to data loss), easily manifest, and are mainly due to design flaws. Our analysis identifies vulnerabilities in core systems mechanisms including scheduling, membership management, and ZooKeeper-based configuration management.
Second, we dissect the design of nine popular systems and identify four principled approaches for tolerating partial partitions. Unfortunately, our analysis shows that implemented fault tolerance techniques are inadequate for modern systems; they either patch a particular mechanism or lead to a complete cluster shutdown, even when alternative network paths exist.
Finally, our findings motivate us to build Nifty, a transparent communication layer that masks partial network partitions. Nifty builds an overlay between nodes to detour packets around partial partitions. Nifty provides an approach for applications to optimize their operation during a partial partition. We demonstrate the benefit of this approach through integrating Nifty with VoltDB, HDFS, and Kafka.
VQEG Column: New topics
Authors: Katsavounidis Ioannis , Robitza Werner , Puri Rohit , Satti Shahid 
Published: December 2022

Welcome to the fourth column on the ACM SIGMM Records from the Video Quality Experts Group (VQEG).
During the last VQEG plenary meeting (14-18 Dec. 2020) various interesting discussions arose regarding new topics not addressed up to then by VQEG groups, which led to launching three new sub-projects and a new project related to: 1) clarifying the computation of spatial and temporal information (SI and TI), 2) including video quality metrics as metadata in compressed bitstreams, 3) Quality of Experience (QoE) metrics for live video streaming applications, and 4) providing guidelines on implementing objective video quality metrics to the video compression community.
The following sections provide more details about these new activities and try to encourage interested readers to follow and get involved in any of them by subscribing to the corresponding reflectors.
VQEG Column: VQEG Meeting Jun. 2021 (virtual/online)
Authors: Gutiérrez Jesús , Brunnström Kjell 
Published: December 2022

Welcome to the fifth column on the ACM SIGMM Records from the Video Quality Experts Group (VQEG).
The last VQEG plenary meeting took place online from 7 to 11 June 2021. As the previous meeting celebrated in December 2020, it was organized online (this time by Kingston University) with multiple sessions spread over five days, allowing remote participation of people from 22 different countries of America, Asia, and Europe. More than 100 participants registered to the meeting and they could attend the 40 presentations and several discussions that took place in all working groups.
This column provides an overview of the recently completed VQEG plenary meeting, while all the information, minutes and files (including the presented slides) from the meeting are available online in the VQEG meeting website.
Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance
Authors: Klümper Niklas , Ralser Damian J. , Ellinger Jörg , Roghmann Florian , Albrecht Julia , Below Eduard , Alajati Abdullah , Sikic Danijel , Breyer Johannes , Bolenz Christian , Zengerling Friedemann , Erben Philipp , Schwamborn Kristina , Wirtz Ralph M. , Horn Thomas , Nagy Dora , Toma Marieta , Kristiansen Glen , Büttner Thomas , Hahn Oliver , Grünwald Viktor , Darr Christopher , Erne Eva , Rausch Steffen , Bedke Jens , Schlack Katrin , Abbas Mahmoud , Zschäbitz Stefanie , Schwab Constantin , Mustea Alexander , Adam Patrick , Manseck Andreas , Wullich Bernd , Ritter Manuel , Hartmann Arndt , Gschwend Jürgen , Weichert Wilko , Erlmeier Franziska , Hölzel Michael , Eckstein Markus 
Published: December 2022

AbstractPurpose:The antibody–drug conjugate enfortumab vedotin (EV) releases a cytotoxic agent into tumor cells via binding to the membrane receptor NECTIN-4. EV was recently approved for patients with metastatic urothelial carcinoma (mUC) without prior assessment of the tumor receptor status as ubiquitous NECTIN-4 expression is assumed. Our objective was to determine the prevalence of membranous NECTIN-4 protein expression in primary tumors (PRIM) and patient-matched distant metastases (MET).Experimental Design:Membranous NECTIN-4 protein expression was measured (H-score) by IHC in PRIM and corresponding MET (N = 137) and in a multicenter EV-treated cohort (N = 47). Progression-free survival (PFS) after initiation of EV treatment was assessed for the NECTIN-4–negative/weak (H-score 0–99) versus moderate/strong (H-score 100–300) subgroup. The specificity of the NECTIN-4 IHC staining protocol was validated by establishing CRISPR-Cas9–induced polyclonal NECTIN-4 knockouts.Results:In our cohort, membranous NECTIN-4 expression significantly decreased during metastatic spread (Wilcoxon matched pairs P &lt; 0.001; median H-score = 40; interquartile range, 0–140), with 39.4% of MET lacking membranous NECTIN-4 expression. In our multicenter EV cohort, absence or weak membranous NECTIN-4 expression (34.0% of the cohort) was associated with a significantly shortened PFS on EV (log-rank P &lt; 0.001).Conclusions:Membranous NECTIN-4 expression is frequently decreased or absent in mUC tissue. Of note, the clinical benefit of EV strongly depends on membranous NECTIN-4 expression. Thus, our results are of highest clinical relevance and argue for a critical reconsideration of the current practice and suggest that the NECTIN-4 receptor status should be determined (ideally in a metastatic/progressive lesion) before initiation of EV.See related commentary by Aggen et al., p. 1377
Evolutionary Characteristics and Immunologic Divergence of Lung and Brain Metastasis Lesions in NSCLC
Authors: Xie Tongji , Liu Zhenghao , Li Yan , Wang Shouzheng , Zhai Yixin , Teng Fei , Hao Xuezhi , Wang Yan , Wang Hongyu , Zhang Xin , Wu Xi , Ying Jianming , Li Junling , Zhang Ye , Deng Yuefei , Xing Puyuan 
Published: December 2022

AbstractBrain metastases (BM) is one of the main reasons for lung cancer-related deaths but lack prediction methods. Many patients with BMs do not benefit from immunotherapy. A comprehensive genomic analysis of matched primary tumors (PT) and their BM lesions may provide new insight into the evolutionary and immune characteristics. To describe evolutionary features and immune characteristic differences, we analyzed whole-exome sequencing data for 28 paired PT and BM samples from 14 patients with non-small cell lung cancer. In addition, we used another 26 matched PT and BM samples as a validation cohort. We found that total mutational signatures were relatively consistent between paired primary and brain metastatic tumors. Nevertheless, the shared mutations of the two lesions were fewer than the mutations present in each of the lesions alone. In the process of BM, driver genes undergo evolutionary branches. Typical driver genes, including EGFR and TP53, appear relatively conserved throughout evolution; however, specific signals are enriched in BM lesions. We found several main characteristics of lung cancer BMs that were different from primary lung cancer, such as genomic instability, novel driver genes, tumor mutation burden, and BM lesion private neoantigens. In addition, the estimated timing of dissemination showed that BMs might occur early in lung cancer.Implications:Mechanistic insight from this study provides new insight into the biology of the metastatic brain process and a new beneficial approach for preventing and treating lung cancer BMs.
Attendance at Supervised Exercise Sessions and Walking Outcomes in Peripheral Artery Disease: Results From 2 Randomized Clinical Trials
Authors: Hammond Michael M. , Tian Lu , Zhao Lihui , Zhang Dongxue , McDermott Mary M. 
Published: December 2022

Background
Supervised exercise therapy (SET) is the first‐line therapy for walking impairment in peripheral artery disease (PAD). This study evaluated the association between attendance at SET and improved walking performance, compared with a control group, in PAD.

Methods and Results

Data from 2 randomized clinical trials of SET for PAD were combined. In each trial, participants were randomized to 3 times weekly supervised treadmill exercise or an attention control group for 6 months (maximum, 77 exercise sessions). Participants randomized to SET were categorized into tertiles, according to the proportion of exercise sessions they attended. Results adjusted for age, sex, race, baseline walking performance, comorbidities, and other potential confounders. A total of 272 participants with PAD (mean age, 67.9±9.3 years; 44% women; 61% Black race) were included. For participants randomized to SET, tertiles of attendance rates at exercise sessions were as follows: 11% to 68% (N=45), 69% to <85% (N=46), and ≥85% (N=46). Compared with control, mean improvement in 6‐minute walk was significantly greater in each SET tertile: mean (95% CI) for tertile 1, 27.9 m (1.3–54.4 m;
P
=0.04), tertile 2, 38.2 m (12.2–64.2 m;
P
=0.001), and tertile 3, 56.9 m (29.9–83.8 m;
P
<0.0001). Among participants randomized to SET, greater SET attendance was associated with greater improvement in 6‐minute walk distance (overall
P
for trend=0.025). Compared with control, improvement in maximal treadmill walking time was greater in each SET attendance tertile: tertile 1 (3.3 minutes [95% CI, 1.7–4.8 minutes];
P
<0.0001), tertile 2 (3.8 minutes [95% CI, 2.3–5.3 minutes];
P
<0.0001), and tertile 3 (5.4 minutes [95% CI, 3.9–7.0 minutes];
P
:<0.0001). Among participants randomized to SET, greater attendance at SET was not significantly associated with greater improvement in maximal treadmill walking time (overall
P
for trend=0.064).

Conclusions
Among people with PAD randomized to SET, better attendance at exercise sessions was associated with significantly greater 6‐minute walk improvement. Among all participants with PAD, even relatively low SET attendance was associated with significantly greater improvement in walking performance, compared with a control group who did not exercise.

Registration

URL:
https://clinicaltrials.gov/ct2/show/NCT01408901
. URL:
https://clinicaltrials.gov/ct2/show/NCT00106327
« L’Algèbre apprend à discourir » La notion de problème de Peletier à Descartes
Authors: Cifoletti Giovanna 
Published: December 2022

Résumé
Lucien Febvre proposait d’étudier comment se formait la raison des gens du XVIe siècle, notamment en langue, logique et mathématiques. Il se trouve que c’est autour de ces trois éléments que Jacques Peletier du Mans écrivit son L’algèbre en 1554 et René Descartes ses Regulae. J’avais montré ailleurs, par une étude lexicale, comment la notion de problème est cruciale dans les Regulae. Je mets ici en évidence les nombreuses correspondances entre les textes algébriques du XVIe siècle et les propos de Descartes concernant la formulation de problèmes, où ils sont transformés en équations. Je montre aussi que, quand Peletier écrit « L’algèbre apprend à discourir », il explicite une posture épistémologique interne à l’algèbre abaciste qui prit consistance en Occident avec la réforme de la dialectique. L’algèbre en particulier et les mathématiques en général ont ainsi peu à peu pris la place de la dialectique comme un art de penser.
L’art de l’analyse de Christiaan Huygens de l’Algebra à la Geometria
Authors: Paoloni Bertrand 
Published: December 2022

Résumé
Célébré par la plupart de ses commentateurs pour la qualité démonstrative de ses traités, le savant Christiaan Huygens (1629-1695) présente un tout autre style dans ses écrits préparatoires. L’ambivalence entre son approche analytique, nourrie par les innovations algébriques de son époque, et l’ordre synthétique de ses publications, a entretenu une illusion persistante sur la véritable nature de son mode opératoire mathématique. L’examen de ses cahiers d’étude et de ses notes de travail montre clairement que Christiaan Huygens était un adepte de la méthode de Fermat, qu’il a utilisée pour une grande variété de problèmes tout au long de sa carrière. Dans le prolongement des études de Giovanna Cifoletti sur ladite méthode et sur sa diffusion, cet article se concentre sur la place de l’oeuvre de Fermat dans le développement de l’art de l’analyse de Huygens, depuis ses premières années de formation (1645-1646) jusqu’à la publication de la Geometria (1659).
La géométrie par problèmes. D’Ozanam à Clairaut puis La Chapelle
Authors: Bernard Alain 
Published: December 2022

Résumé
Le mode d’organisation par problèmes qui caractérise les Éléments de Géométrie d’Alexis Clairaut (1741) trouve plausiblement son origine dans l’introduction d’une catégorie éditoriale nouvelle dans une des éditions françaises des huit livres d’Euclide par le père Jésuite Claude-François Milliet-Dechales (1677) : celle des « Usages » adjoints à certaines propositions. La transformation de cette nouveauté éditoriale dans les commentaires de Jacques Ozanam au texte de Dechales en 1690, puis sa réélaboration dans son Cours mathématiques de 1693, conduit à un dispositif d’introduction à la géométrie très proche de ce que proposera ensuite Clairaut, moyennant plusieurs simplifications drastiques. Cette reconstruction est étayée par la lecture que proposera plus tard La Chapelle, dans ses Institutions de Géométrie (1746) aussi bien des « Usages » de Dechales et d’Ozanam que de la méthode d’exposition de Clairaut. Nous montrons au passage que La Chapelle s’inspire largement de cette dernière.
Crawford’s Multilateralism and the International Court of Justice
Authors: McIntyre Juliette 
Published: December 2022

Abstract
Over the course of his distinguished career, one of the central focus points in the work of Judge James Crawford was the role for the International Court of Justice in multilateral disputes and those engaging community norms. There are two judicial procedures in respect of which the multilateral or communitarian nature of the dispute is particularly contentious: standing, and intervention. This paper considers the Court’s most recent jurisprudence in respect of these procedures, with particular attention paid to Crawford’s own engagement with this field as both a scholar and Judge.
Socioeconomic Disparities in Neoadjuvant Chemotherapy for Early-Stage Breast Cancer
Authors: Reissis Yannis , Wolfe Luke , Karim Tahia , Mosquera Catalina , McGuire Kandace 
Published: December 2022

Background Neoadjuvant chemotherapy (NCT) is often used for patients with early-stage breast cancer. Disparities in the use of NCT based on clinical, demographic, and socioeconomic factors have not been evaluated. Methods Data from the National Cancer Database was analyzed for patients with T1-2, N0-1 breast cancer from 2006 to 2015. Univariate and multivariate analysis determined which factors predicted for the receipt of NCT. Results We found 159 946 eligible patients. Factors associated with receipt of NCT included T2 vs. T1 disease, N1 vs. N0, and treatment at an academic facility. Race itself was not significant; however, a higher level of education amongst Black populations correlated with the receipt of NCT. Discussion Clinical factors are the greatest determinants for receipt of NCT in early-stage breast cancer. Disparities exist that cannot be explained by race alone; socioeconomic and demographic factors are important. Cancer care should be evaluated in the context of the intersectionality of these health determinants.
Use of Polyglycolic Acid Sheets for the Prevention of Pancreatic Fistula after Laparoscopic Gastrectomy: A Single-Center Retrospective Study
Authors: Iwasaki Kenichi , Barroga Edward , Enomoto Masaya , Matsumoto Moe , Yamada Erika , Miyoshi Kenta , Shimoda Yota , Ota Yoshihiro , Nakagawa Yuichi 
Published: December 2022

Background Laparoscopic gastrectomy (LG) indications have been extended to advanced gastric cancer requiring expansive lymph node dissection. Despite the huge benefits of this minimally invasive surgery, major complications such as postoperative pancreatic fistula (POPF) remain a concern. With technical advances in surgical procedures, the treatment outcomes of gastric cancer surgery have improved. However, effective methods for preventing POPF have not yet been established. Herein, we examined the usefulness of polyglycolic acid (PGA) sheets for preventing POPF after LG. Methods We retrospectively assessed 142 patients who underwent curative LG at our institution between January 2017 and August 2022. The 142 patients were divided into 2 groups; PGA group (n = 61): the site of lymph node dissection at the superior margin of the pancreas and pancreatic head was covered with PGA sheets, and nPGA group (n = 81): the site was not covered. We retrospectively compared the short-term surgical outcomes including POPF incidence. Results There was no significant difference in the background factors between the 2 groups and in the incidence of Grade II or higher postoperative complications according to the Clavien-Dindo (CD) classification. However, the incidence of CD Grade II or higher POPF was significantly lower in the PGA group than in the nPGA group (.0% vs 2.3%, respectively, P = .007). Conclusions There was no POPF in any of the 61 patients in the PGA group. This outcome suggests that POPF incidence may be reduced by covering the lymph node dissection site with PGA sheets after LG.