bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reference Intervals of Haematological Indices for Young Adults with Sickle Cell Anaemia in Southwestern Nigeria
Authors: Asafa Muritala Abiola. , Ahmed Ibrahim Oluwaseun. , Agim Mary Boluwatife. , Fabinu Taofik Ayodeji. , Kusoro Simeon Oluseyi. , Ogunoye Blessing Toyosi , Ogunlade Oluwadare , Bolarinwa Rahman Ayodele 
Published: January 2025

Abstract

Background
Reference intervals (RIs) are crucial for the interpretation of results and overall patient management. Of note, there are no established reference values for haematological parameters for patients with sickle cell anaemia (SCA) in Nigeria, making it difficult for clinicians to interpret and diagnose abnormalities appropriately.
Objective
This study aimed at establishing RIs of some haematological indices for individuals with SCA.
Methods
This descriptive cross-sectional study, included a total of six hundred and seventy-eight (337 males and 341 females) young adults with SCA aged 18–35 years. The full blood count (FBC) was done using a haematology autoanalyzer. The haematological indices were classified using 2.5th and 97.5th percentiles and delineated as low (< 2.5th percentile), normal reference interval (2.5–97.5th percentile) and high (> 97.5th percentile). All analyses were done using SPSS IBM, version 20.0 software
Results
Generally, the reference interval for Haematocrit is 5.2-9.2g/dl, while the WBC ranged between 5.9 to 12.1 x 109/l and the platelet count is 166–465 x 109/l. For the male participants, the reference interval of the haematocrit was found to be between 5.2-9.3g/dl, the WBC ranged between 6.7 to 12.1 x 109/l and the platelet count was between 166 x 109/l to 399 x 109/l. The female subjects had a haematocrit of between 5.5g/dl to 8.8 g/dl, WBC of between 5.9 109/l and 12.96 x 109/l and the platelet count was between 225 x 109/l and 465 x 109/l.
Conclusion
This study has established the reference intervals for the haematological indices in individuals with SCA
A human interruption-free robotic platform for autonomous analysis of urinary samples
Authors: Islam M. Humayet , Islam M. Robiul , Rabbi G. , Uddin M. Jalal 
Published: January 2025

Abstract

Urine, a bodily by-product which conveys a number of physiological insights is a potential candidate for ongoing, regular health assessment. Despite their remarkable advancements, automated urine analyzers remain laboratory-based instruments that need labor-intensive sample processing and analysis, rendering them unsuitable for routine health screening. To expedite routine health screening, this work reports on a human interruption-free robotic platform that bypasses the manual operation for biological sample assay including handling of assay steps and colorimetric analysis of target markers in the sample. The robotic arm and the customized Android app; the key components of the platform automate the assay inside an imaging chamber eluding manual operation under similar assay protocols for multiple measurements and processes post-assayed image to quantify the target urine markers. Detailed characterization of the robotic operation, light distribution, and image analysis of the proposed platform was applied in the detection of glucose, protein and pH level in artificial urine sample that reveals a set of essential performance parameters that are comparable to, or even better than, that of conventional urine assay. As a result, it is believed that the proposed device may suitably be applied for autonomous analysis of other biological samples as a routine point-of-care (PoC) device.
ENERGY EFFICIENCY OF SOLAR POWER GENERATION PLANTS: A DEA-OLS BASED STUDY OF ‘SAI MITRA’
Authors: Prusty Rameswar , Sivakumar Prof N. 
Published: January 2025

Abstract

The demand for renewable energy sources has grown significantly due to the increasing environmental damage caused by pollution and high carbon emissions by traditional sources of energy. Energy efficiency plays a crucial role in solar power generation, a highly effective form of renewable energy. This paper aims to explore energy efficiency in solar power generation plants through a two-stage DEA-OLS approach using data from Sai Mitra, a multi-capacity solar power generation system in India. The findings of the study underscore the significance of adopting a holistic management approach for solar power plants, utilizing key ratios that combine desirable and non-desirable performance parameters.
Targeting Snail2 improve sensitivity to parthenolide in T-cell acute lymphoblastic leukemia through PUMA activation
Authors: cao cuiming , ZHOU YAWEI , WANG WEICHEN 
Published: January 2025

Abstract

Background and Objective:
Current therapies for childhood T-cell acute lymphoblastic leukemia (T-ALL) have increased survival rates to about 85%. The standard of care is chemotherapy, but approximately 20% patients exhibit primary or secondary resistance to current therapies. Parthenolide (PTL) has been shown to have excellent anti-cancer activity in pediatric leukemia xenografts, with minimal effects on normal hemopoietic cells. Some leukemia initiating cell populations remain resistant to PTL. This study examined mechanisms for this resistance and how to overcome the resistance.
Methods:
Snail2 protein expression was detected in 9 T-ALL patients, 9 normal bone marrow (NBM) cells and 4 T-ALL cell lines. We investigated the effects of loss of-function and gain-of-function of Snail2 or P53 up-regulated modulator of apoptosis on survival, colony formation, apoptosis and chemosensitivity of T-ALL cells to PTL in vitro and in vivo.
Results:
Snail2 protein expression was elevated in primary T-ALL patients and cell lines. CEM cells with rich Snail2 expression is resistant to PTL. JURKAT cells with poor Snail2 expression sensitizes to PTL. In vitro, Snail2 inhibition by siRNA, sensitized CEM cells to apoptosis by PTL, resulting in PUMA upregulation and caspase-3 cleavage. Inhibition of PUMA by RNA interference in Snail2-knockdown CEM cells rescued the resistance of CEM cells to PTL treatment. Snail2 re-expression in JURKAT cells is resistant to PTL. The pro-survival effect of Snail2 was found to be caused by direct repression of PTL-induced PUMA expression by Snail2 in JURKAT cells. Additionally, an orthotopic allograft in vivo model demonstrated that the Snail2 inhibitor enhanced responses to PTL in CEM cells by inducing PUMA-dependent cell apoptosis.
Conclusion:
This study demonstrates a pivotal role for Snail2/PUMA signals in T-ALL cell survival. It may be possible to achieve greater toxicity to childhood T-ALL by combining PTL with Snail2 knockdown.
Teacher competence in inclusive mathematics education: Examining the effects of an innovative professional development program on teacher noticing
Authors: Bastian Anton , König Johannes , Ross Natalie , Klee-Schramm Isabelle , Sommer Dennis , Strauß Sarah , Rott Benjamin , Kaiser Gabriele 
Published: January 2025

Abstract

This study investigated the effects of an innovative professional development program aimed at enhancing teacher noticing skills and professional knowledge in inclusive (mathematics) education in secondary algebra instruction. A total of 653 participants, comprising master’s students, teachers in preparatory service, and in-service teachers from Germany, participated in a pretest–posttest evaluation design that included a control group. The program comprised 18 hours of coursework that integrated novel teaching materials and video-based learning activities that combined both mathematics pedagogical and general pedagogical perspectives on teacher noticing and associated knowledge. The results indicated significant improvements in teachers’ noticing skills and professional knowledge for the intervention group across all investigated facets, particularly for teacher noticing under a pedagogical perspective and mathematics pedagogical knowledge, compared to a control group that exhibited no significant changes. Effect sizes ranged from small to medium, suggesting that the professional development program effectively improved participants’ knowledge of inclusive teaching and their abilities to perceive, interpret, and make decisions in inclusive contexts. Notably, master’s students exhibited the most substantial gains in all competencies, while in-service teachers primarily improved their teacher noticing from a pedagogical perspective. The findings underscore the importance of tailored professional development for fostering teacher noticing in inclusive mathematics education and yield valuable insights into the competencies necessary for inclusive (mathematics) education.
Nativity, Racial/Ethnic, and Length of US Residence Differences in Chronic Kidney Disease: National Health and Nutrition Examination Survey 2011-March 2020
Authors: Ogungbe Oluwabunmi , Turkson-Ocran Ruth-Alma , Tomiwa Tosin , Adeleye Khadijat , Rayani Asma , Hinneh Thomas , Baptiste Diana , Hladek Melissa D. , Crews Deidra C. , Commodore-Mensah Yvonne 
Published: January 2025

Abstract

Rationale: The chronic kidney disease (CKD) burden in the US varies by race/ethnicity. It was unclear whether nativity status influences these disparities. This study compared CKD prevalence by nativity status, race and ethnicity, and length of US residence.
Study Design: Cross-sectional analysis.
Setting/Participants: We drew a weighted sample of 13,636 adults representing 155,147,141 Hispanic, White, Black, and Asian adults from the pooled 2011-March 2020 National Health and Nutrition Examination Survey (NHANES), which included 155,147,141 US-and foreign-born adults.
Exposures: Nativity (US-or foreign-born), race/ethnicity, and length of US residence.
Outcome: We defined CKD as eGFR <60mL/min/1.73m 2 or a urinary albumin-to-creatinine ratio ≥30 mg/g.
Analytical Approach: Survey-weighted multivariable Poisson models estimated associations among nativity status, race, and ethnicity, length of US residence, and CKD, adjusting for covariates.
Results: The prevalence of CKD among US-born adults was 14.0%, vs. 11.5% of foreign-born. Foreign-born adults were less likely to have CKD (prevalence rate ratio [PRR]: 0.75, 95% CI 0.60-0.93) than US-born adults, adjusting for age, sex, and socioeconomic factors. Black adults were more likely to have CKD than White adults (PRR: 1.44, 95% CI 1.23-1.68); this difference was greater among US-born adults (PRR: 1.48, 95% CI 1.25-1.76). Among Hispanic and Asian adults, age-and sex-adjusted prevalence of CKD increased with longer length of residence in the US.
Conclusions: There are clear CKD disparities related to nativity location and length of US residence, and these vary by race/ethnicity. Interventions addressing the unique challenges faced by populations most at risk for CKD, such as access to healthcare barriers and socioeconomic disparities, may help mitigate the burden of CKD and promote health equity.
Association between uric acid to lymphocyte ratio and poor functional outcomes in acute ischemic stroke patients
Authors: Zhu Xu , Zhang Yijun , Wang Anxin , Zhang Xiaoli , Yu Guoyuan , Xiang Shifeng , Wu Yiping , Meng Xia 
Published: January 2025

Abstract

Background Inflammation has an important impact on the pathological progression associated with ischemic stroke. Serum uric acid (UA) to lymphocyte ratio (ULR) is a biomarker that responds to the level of inflammation but is not definitively associated with the clinical outcomes in patients with acute ischemic stroke (AIS);Methods The data were obtained from the Third China National Stroke Registry (CNSR-III). Enrolled AIS patients were grouped by ULR quartiles at admission. The outcomes were poor functional outcomes (modified Rankin Scale [mRS] score of 3–6 or 2–6) and all-cause mortality at 3 months and 1 year. The associations of ULR with the risk of poor functional outcome and all-cause mortality were analyzed by multivariable logistic regression and Cox proportional hazards regression;Results A total of 8241 patients were included from the CNSR-III study. After adjusting for confounders, it was found that patients in the highest ULR quartile had higher mRS scores of 2–6 (odds ratio [OR], 1.33; 95% confidence interval [CI], 1.15–1.53) and 3–6 (OR, 1.35; 95% CI, 1.16–1.57) at the 3-month follow-up. Additionally, the highest ULR quartile was associated with an increased risk of all-cause mortality at the 3-month follow-up (hazard ratio [HR], 1.97; 95%CI, 1.22–3.18). Similar results were observed at the 1-year follow-up;Conclusion Elevated ULR increased the risks of poorer functional outcomes and all-cause mortality in the AIS patients.
Circulating Levels of miR-155 and CTBP1-AS2 as a promising biomarker for early detection of diabetic nephropathy
Authors: Rahimi Arezoo , Nikooei Shekoofeh , Roozbehi Khatere , Semirani Davood , Larki Rozina Abasi , Arya Arash , Gholami Danial , Alipoor Behnam 
Published: January 2025

Abstract

Background
Diabetic nephropathy (DN) is one of the most frequent complications of diabetes mellitus. Since the early diagnosis of DN is crucial to prevent the progression of the disease towards renal failure, many efforts have been made in recent years to introduce new diagnostic biomarkers. Recent studies suggest that non-coding RNAs could act as a novel diagnostic biomarker for the early detection and prediction of DN progress. Accordingly, in the current study we investigated the expression levels of miR-155 and CTBP1-AS2 in type 2 diabetes (T2D), DN patients and control subjects and evaluated their diagnostic potential for DN.
Method
A total of 189 age and sex-matched subjects including 65 T2D patients with normo-albuminuria, 61 DN patients who had a history of albuminuria, and 63 control subjects were included in this case-control study. The expression levels of miR-155 and CTBP1-AS2 were determined using QRT-PCR.
Results
The results revealed that the expression level of miR-155 was significantly reduced in T2D patients. In addition, miR-155 level was significantly higher in DN patients with macroalbuminuria compared to DN patients with microalbuminuria and T2D patients with normo-albuminuria. The expression level of CTBP1-AS2 in T2D without proteinuria was higher than DN subjects with macroalbuminuria. The results also showed that there was a significant positive correlation between the miR-155 level with DBP, TG, TC, SCr and, BUN levels and a negative correlation with HDL-C and eGFR values.
Conclusion
Deregulation levels of miR-155 and CTBP1-AS2 may represent useful novel diagnostic biomarkers for DN.
Weight Optimization of Coverage Matrix for Fault Localization
Authors: Hu Jian 
Published: January 2025

Abstract

Coverage-based fault localization (CFL) is a widely used technique for localizing faults in software systems. It relies on the analysis of program execution traces or coverage information to locate suspicious components that are likely to contain the fault. However, the raw coverage matrix used in fault localization encounters two primary challenges: (1) it contains a substantial number of fault-irrelevant statements, and (2) it only considers the coverage information from the tests without taking into account its degree of importance within the entire test suite. This paper addresses the aforementioned challenges by introducing a two-stage weight optimization approach for the coverage matrix in fault localization (FL). In the first stage, our method focuses on optimizing the weight of fault-irrelevant statements, which are identified through program slicing of the failing tests. In the second stage, we optimize the weights of fault-relevant statements by considering their significance within the test suite. The outcome is a weight-optimized coverage matrix that serves as input data for the fault localization algorithm. To evaluate the effectiveness of our method, we conducted extensive experiments using ten state-of-the-art fault localization techniques on widely-used benchmarks. Our method can effectively reduce the number of lines required to locate faults across all versions. On average, it achieves a reduction of 34% for SFL and 47% for DLFL.
Effectiveness of interventions in teacher education: Synthesis of reviews (2010–2024)
Authors: König Johannes , Heine Sandra , Weyers Jonas , Arntz Carl-Gereon , Kramer Charlotte , Strauß Sarah , Gerhard Kristina , Mühle Janine , Engartner Tim , Großschedl Jörg , Hanisch Charlotte , Hanke Petra , Hennemann Thomas , Jost Jörg , Kaspar Kai , Rott Benjamin 
Published: January 2025

Abstract

This paper offers an overview of current research on the effectiveness of interventions in teacher education. We synthesize 27 reviews published between 2010 and 2024, comprising 510 research publications of empirical intervention studies targeting pre-service and in-service teachers’ professional learning. We applied a specific analysis category system to address five research questions concerning (1) theoretical foundations, (2) input and output of the intervention studies, (3) study design, (4) effect sizes, and (5) research gaps. Few reviews had developed their own theoretical framework, and justifications for the interventions’ necessity were not always elaborated. Most assumed the existence of an effect chain—namely, that the reviewed interventions help promote teacher variables (mainly competence facets), which are then positively reflected in teaching quality and students’ learning gains. However, study variables typically indicate only segments of the effect chain while comprehensive operationalization of the total effect chain is rare. Interventions are typically organized as coursework, not necessarily connected to teaching practice or student learning. The interventions’ targeted learning outcomes are heterogeneously operationalized. Basic design features appear typical for intervention studies in teacher education, whereas more challenging designs are less common. Self-report instruments appear more common than rigorous measurement approaches. Based on a subsample of 14 reviews reporting summarized effects sizes, we conducted a meta-meta-analysis that shows an overall significant moderate effect of interventions is observable. Differentiation shows stronger effects for proximal outcomes (e.g., change in teacher knowledge or instructional practice) than for student learning. The synthesis of moderator effects yielded mixed results, and the quality of interventions appears more crucial than the length. Research gaps concern further theoretical development, the individual intervention studies’ research methodological standards, and improvement of literature reviews’ methodological quality. The results offer a theoretical background for future research on teacher education interventions and research progress in teacher education effectiveness.
The Exosome and its Application in Skin Wound Healing: A Systematic Review on In vitro Studies
Authors: Heydari Mohammad Bagher , Ghanbari-Movahed Zahra , Heydari Maryam , Farzaei Mohammad Hosein 
Published: January 2025

Background:
Wound healing is a complex procedure frequently delayed in patients
with underlying chronic conditions. Despite essential advances in tissue engineering and regenerative
medicine, wound healing remains challenging, warranting novel methods for promoting
wound healing. It has been demonstrated that exosomes are one of the main secretory products
of different cell types, such as Mesenchymal Stem Cells (MSCs), for regulating various biological
processes, including wound healing. Henceforth, understanding these exosome effects might
assist in improving wound management and highlight a novel therapeutic model for cell-free
therapies with reduced side effects for repairing wounds.

Methods:
This systematic review involved conducting research electronically on scholarly scientific
databases, including PubMed, Science Direct, and Scopus. Eligibility checks were performed
based on predefined selection criteria. Finally, thirty-nine studies were considered.

Results:
Exosomes have been indicated to use multitargeted pathways to improve wound healing
by modulating numerous dysregulated signaling cascades involved in cell proliferation, cell cycle
regulation, metastasis, apoptosis, and angiogenesis.

Conclusion:
The outcome of this review might guide pre-clinical and clinical studies on the role
of exosomes in skin wound healing.
Repurposing Nano Curcumin: Unveiling its Therapeutic Potential in Diabetic Nephropathy
Authors: Sharma Rarchita , Mali Yogesh , Agrawal Yogeeta. O. , Agnihotri Vinit V. , Goyal Sameer N. 
Published: January 2025

Abstract:
Currently, diabetic nephropathy (DN) stands as the predominant global cause of endstage
renal disease. Many scientists believe that diabetes will eventually spread to pandemic levels
due to the rising prevalence of the disease. While the primary factor leading to diabetic nephropathy
is vascular dysfunction induced by hyperglycemia, several other pathological elements, such
as fibrosis, inflammation, and oxidative stress, also contribute to the progression of the disease.
The primary targets of current DN therapy approaches are the underlying abnormalities of hypertension
and glucose. With several targets and fewer side effects, curcumin is a commonly utilized
antioxidant in DN. The present study emphasizes the critical role of oxidative stress and inflammation
in the development of diabetic nephropathy. It reveals how these factors induce damage in
key kidney cell types, highlighting their potential as therapeutic targets for this disease. In addition,
by concentrating on Nrf2, SIRT1, HMGB1, NF-κB, and NLRP3 of curcumin, has strong anti-
inflammatory and antioxidant characteristics. This review describes the role of curcumin in the
therapeutic application of diabetic nephropathy. In this attempt, we tried to elaborate on the
bench-to-bedside aspects of curcumin in DN, including clinical and preclinical investigations. The
rationales of curcumin’s mechanisms in alleviating symptoms of the DN were discussed. Curcumin
could serve as the potential therapeutic agent for the patient seeking to recover from DN.
Extraction, Isolation and Purification of Catechins and their Applications
Authors: Cao Hong-Mei , Fang Jiao-Jiao , Zhao Yi-Tao , Zhao Pei-Hong , Chen Xin 
Published: January 2025

Abstract:
Catechins, the main active components of tea polyphenols, boast remarkable antioxidant
activities because of their unique structures. This translates to a range of potential health benefits,
including fighting antibacterial, inflammation, and even cancers. However, extracting these beneficial
compounds can be tricky as they're prone to degradation. Thankfully, recent advancements
have yielded successful methods for isolating and purifying catechins, allowing us to obtain them in
their purest form. The power of catechins isn't just theoretical. In vitro and in vivo studies have
demonstrated promising results in treating various conditions like inflammation, cancer, neurodegenerative
diseases, cardiovascular diseases, diabetes, and more. This review dives deep into the
methods used to extract, isolate, and purify catechins. Additionally, it explores their potent antioxidant
activities and exciting possibilities for future applications.