bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diacronía de los resultados secundarios del diptongo /ue/ en judeoespañol
Authors: Arias Álvaro 
Published: June 2023

AbstractJudeo-Spanish presents some surprising results as regards the secondary evolution of the diphthong /ˈue/. Contrary to Spanishjueves‘Thursday’,tuerto‘one-eyed’,sueño‘dream’,nuera‘daughter-in-law’, Judeo-Spanish hasĵugüeves,tugüerto,(e)sfueño, andelmuera. That is, /ˈue/ has evolved either into /u.ˈgue/, it has developed a fricative before the diphthong (/ˈsue/ > /s.ˈfue/), or labialized the previous nasal (/ˈnue/ > /ˈmue/).In this study we present an explanation for this phenomenon that combines the regular Ibero-Romance phonic evolution and some language-specific features of the evolution of Judeo-Spanish, without an explicit appeal to exceptional solutions. Our hypothesis is based on the realization of the sequence /ˈue/ as a hiatus (ĵu.e.ves,tu.er.to,su.e.ño,nu.e.ra) which eventually developed an epenthetic consonant. This epenthesis was velar (ĵugueves,tuguerto), the latter case also involving further vowel insertion in agreement with the historical phonetics of Judeo-Spanish (ĵugüeves,tugüerto). Examples with labial fricatives or nasals preceding the diphthong have followed this evolution and then lost the pretonic vowel, giving way to a consonantal cluster in which the second consonant is partially assimilated to the first (sueño> *s(u)güeño>sfueñooresfueño;nuera>n(u)güera> *enmuera>elmuera,ermuera>muera).
The diachronic path ofacharin Portuguese: from a propositional to an epistemic verb
Authors: Pinto Clara 
Published: June 2023

AbstractIn this article I investigate the diachronic path of the Portuguese verbachar‘to find/consider’, from a main propositional verb (in the sense of Traugott 1989), in earlier stages of the language, to a verb with epistemic reading, which is the default interpretation in Contemporary European Portuguese (CEP). Based on a sample corpus of texts comprehended between the 13th and the 17th century, I have concluded that the epistemic reading ofacharwas incipient until the 16th century, despite the existence of a few examples in the 13th century. This grammaticalization process seems to be recent in the language since epistemic readings remain infrequent until the 17th century and I did not find parenthetical uses in the corpus. Nevertheless, data under analysis allowed me to identify two possible syntactic contexts that may have favoured the semantic change: complement clauses and transitive-predicative constructions. The evolution ofachar‘to find/consider’ seems to follow the pattern of semantic change proposed by Traugott (1989) and Traugott/Dasher (2002) under the notion ofsubjectification, withacharstarting with an objective meaning and later acquiring an epistemic reading, following the assumption that meanings tend to become centered in the subjective belief or attitude of the speaker.
Ativismo Feminista Online: mapeando eixos de atuação
Authors: Sarmento Rayza 
Published: June 2023

Este texto busca sistematizar as formas da agência feminista online, entendendo-as como expressão dos feminismos contemporâneos, sobretudo vinculados à experiência de mulheres jovens. Exploramos os fenômenos práticos e os estudos voltados para cinco dimensões, como forma de compreensão mais sistematizada dos elementos e processos políticos e discursivos ligados ao ativismo feminista digital: a) aquele relativo à arquitetura da rede; b) a construção de redes de informação e contranarrativa; c) os grupos de engajamento e solidariedade; d) as campanhas visibilizadas principalmente a partir de hashtags e o e) combate à violência digital de gênero.
Diversity of Ganglion Cell Responses to Saccade-Like Image Shifts in the Primate Retina
Authors: Krüppel Steffen , Khani Mohammad H. , Karamanlis Dimokratis , Erol Yunus C. , Zapp Sören J. , Mietsch Matthias , Protti Dario A. , Rozenblit Fernando , Gollisch Tim 
Published: June 2023

Saccades are a fundamental part of natural vision. They interrupt fixations of the visual gaze and rapidly shift the image that falls onto the retina. These stimulus dynamics can cause activation or suppression of different retinal ganglion cells, but how they affect the encoding of visual information in different types of ganglion cells is largely unknown. Here, we recorded spiking responses to saccade-like shifts of luminance gratings from ganglion cells in isolated marmoset retinas and investigated how the activity depended on the combination of presaccadic and postsaccadic images. All identified cell types, On and Off parasol and midget cells, as well as a type of Large Off cells, displayed distinct response patterns, including particular sensitivity to either the presaccadic or the postsaccadic image or combinations thereof. In addition, Off parasol and Large Off cells, but not On cells, showed pronounced sensitivity to whether the image changed across the transition. Stimulus sensitivity of On cells could be explained based on their responses to step changes in light intensity, whereas Off cells, in particular, parasol and the Large Off cells, seem to be affected by additional interactions that are not triggered during simple light-intensity flashes. Together, our data show that ganglion cells in the primate retina are sensitive to different combinations of presaccadic and postsaccadic visual stimuli. This contributes to the functional diversity of the output signals of the retina and to asymmetries between On and Off pathways and provides evidence of signal processing beyond what is triggered by isolated steps in light intensity.SIGNIFICANCE STATEMENTSudden eye movements (saccades) shift our direction of gaze, bringing new images in focus on our retinas. To study how retinal neurons deal with these rapid image transitions, we recorded spiking activity from ganglion cells, the output neurons of the retina, in isolated retinas of marmoset monkeys while shifting a projected image in a saccade-like fashion across the retina. We found that the cells do not just respond to the newly fixated image, but that different types of ganglion cells display different sensitivities to the presaccadic and postsaccadic stimulus patterns. Certain Off cells, for example, are sensitive to changes in the image across transitions, which contributes to differences between On and Off information channels and extends the range of encoded stimulus features.
Child Pedestrian Safety
Authors: Kendi Sadiqa , Johnston Brian D. ,   COUNCIL ON INJURY, VIOLENCE, AND POISON PREVENTION, Hoffman Benjamin , Agran Phyllis F. , Culyba Alison , Dodington James , Lee Lois K. , McFadden Terri , Monroe Kathy , Tenenbein Milton , Quinlan Kyran , Beno Suzanne , Dixon Cinnamon , Dunn Laura , Midgett Jonathan D. , Miller Bethany , Qualters Judith , Kozial Bonnie 
Published: June 2023

The field of pedestrian safety has advanced with new evidence related to pediatric pedestrian education, the risks of distracted walking, the benefits of design and programming in safe routes to school, and the emergence of the “Vision Zero” strategy to eliminate all traffic fatalities and severe injuries while increasing safe, healthy, equitable mobility for all.
This statement is a revision of the 2009 American Academy of Pediatrics policy statement “Pedestrian Safety” and is accompanied by a technical report (www.pediatrics.org/cgi/doi/10.1542/peds.2023-062508) providing additional detail to support recommendations. This statement is intended to assist practicing pediatricians to offer evidence-based advice to families about the benefits of active transportation and the specific risks and safety precautions to consider for child pedestrians at different ages. For community pediatricians and the American Academy of Pediatrics, the statement provides an overview of specific programs and policies that, if implemented, could foster independent mobility for children while increasing pediatric pedestrian safety. This statement identifies trends in public health and urban design relevant to pedestrian safety.
WebMRI: Brain extraction and linear registration in the web browser
Authors: Harmouche Ahmed , Kövér Ferenc , Szukits Sándor , Dóczi Tamás , Bogner Péter , Tóth Arnold 
Published: June 2023

AbstractBackground and AimSince the initial release of the World Wide Web, the capabilities of web browsers have grown from presenting formatted documents to running complex programs, such as 3D game engines. The medical imaging community started to adopt technologies that came with the fifth major version of the HyperText Markup Language (HTML5). It led to the creation of various web-based radiological applications such as cornerstone.js or BrainBrowser. BrainBrowser supports both 3D and 2D rendering of neuroimaging data. However, it cannot run important image processing algorithms, such as brain extraction and linear registration, which are essential in most neuroimaging workflows. The most commonly used library that supports these algorithms is the FMRIB Software Library (FSL). We aim to build a web-based cross-platform neuroimaging platform that combines data visualization with image processing.MethodsWe built our system as an extension of BrainBrowser. We developed WebMRI in JavaScript and designed the user interface using HTML, CSS, and Bootstrap. We used Emscripten to port the brain extraction and linear registration tools of FSL to the web.ResultsWe built WebMRI, a fully web-based extensible neuroimaging platform that combines the visualization capabilities of BrainBrowser with the brain extraction and linear registration tools of FSL by porting them from C++ to WebAssembly. We extended BrainBrowser with a plugin system that makes it easy to bring other processing algorithms into the platform. We released the WebMRI source code on Github: https://github.com/wpmed92/WebMRI.ConclusionsWe developed and released WebMRI, a web-based cross-platform open-source neuroimaging platform.
Successful transcatheter aortic valve replacement in a patient with radiation-induced aortic stenosis
Authors: Zubarev D. D. , Sim S. V. , Krasnov V. S. , Gorbatykh A. V. , Chernyavsky M. A. , Prokhorikhin A. A. 
Published: June 2023

Aortic stenosis is one of the most common valvular heart defects that occurs in patients with oncology after radiation therapy and requires surgical treatment. However, this group of patients has a higher risk of intra- and postoperative complications, and therefore the most optimal method of surgical treatment of aortic stenosis in such a cohort of patients is transcatheter aortic valve implan­tation (TAVI).Brief description. Forty-six-year old woman entered the Almazov National Medi­cal Research Center with a clinical picture of severe aortic stenosis. At a young age, the patient was diagnosed with lymphogranulomatosis, or Hodgkin’s disease, for which radiation therapy was performed, which was complicated in the long term by valvular pathology. After a thorough examination, a high intraoperative risk for the patient was determined by the cardiac team and endovascular treatment of severe aortic stenosis was performed. The postoperative period was complicated by the development of complete atrioventricular block, which caused the implantation of a permanent dual-chamber pacemaker.Discussion. The presented case is an example of successful surgical treatment of aortic stenosis associated with previous radiation therapy for Hodgkin’s disease in a patient.Conclusion. Endovascular aortic valve implantation is a promising approach to the treatment of patients with post-radiation aortic stenosis, since it is associated with unfavorable anatomical and clinical risk factors for surgical valve replacement. Despite their younger age, these patients represent a category of higher surgical risk. Therefore, additional attention should be paid to the planning of the procedure and the prevention of the main TAVI risks.
Short‑to‑mid‑term follow‑up results of transcatheter closure of atrial septal defect in patients older than 60 years
Authors: Le T. K. , Nguyen Minh N. , Hoang T. H. 
Published: June 2023

Aim. To assess short-to-mid-term clinical and echocardiographic outcomes and identify factors associated with pulmonary arterial hypertension (PAH) in patients older than 60 years.Material and methods. Retrospective single-center study of 51 consecutive patients (mean age 63,3±3,2 years, 76% females) undergoing percutaneous ASD closure. Functional status, right ventricular (RV) remodeling and pulmonary artery systolic pressure (PASP) was assessed before and 24 hours after the procedure, at 6 months and 12 months.Results. The mean ASD size was 21,8±4,4 mm. Compared to before procedure, at 24 hours a significant improvement of NYHA class (NYHA II-III 7 (13,7%) vs. 34 (66,7%) patients, p<0,0001, respectively), RV size (26,9±5,7 vs. 31,3±5,7 mm, p<0,0001, respectively) and PASP (26,9±5,7 vs. 50,4±14,2 mm Hg, p<0,001) was detected. At 1 year, RV size and PASP decreased to 22±4,6 mm, p<0,0001 and 33,8±10,8 mm Hg, p<0,0001, respectively, compared to before ASD closure, PAH remained in 10 (19,6%) patients. Pre-intervention PASP ≥57,5 mm Hg was an independent predictor of residual PAH at 1 year (odds ratio 1,31, 95% confidence interval (CI) 1,04-1,67, p=0,024; c-statistics 0,939, 95% CI 0,865-1,0, p<0,001, sensitivity 80%, specificity 92,6%).Conclusion. Percutaneous ASD closure in elderly patients was associated with regression of RV size and PASP, as well as symptomatic improvement in the short- and medium-term. Pre-intervention PASP was an independent predictor associated with residual PAH after one year.
Antiplatelet therapy de-escalation in a patient after percutaneous coronary intervention with a high risk of bleeding
Authors: Kassymova A. A. , Mansurova J. A. , Karazhanova L. K. , Chinybayeva A. A. 
Published: June 2023

According to recommendations of ESC 2020-year, de-escalation of therapy with a P2Y12 receptor inhibitor (transition from prasugrel or ticagrelor to clopidogrel) It can be considered as an alternative strategy of dual antiplatelet therapy (DAPT) for patients with acute coronary syndrome (ACS) who are unsuitable for the use of a strong platelet inhibitor.De-escalation can be performed based on an individual clinical evaluation under the supervision of platelet function testing or CYP2C19 genotyping, depending on the patient’s risk profile and the availability of appropriate diagnostic methods. The optimal dosage of strong P2Y12 receptor inhibitors, such as ticagrelor or prasugrel is not entirely clear and is especially difficult to define for patients of Asian nationality.The article describes a clinical case of antiplatelet therapy de-escalation, particularly a dose reduction of the potent P2Y12 receptor inhibitor ticagrelor in a patient after percutaneous coronary intervention (PCI) with a high risk of bleeding based on platelet function determination and genetic testing. A 47-year-old patient of Kazakh nationality was hospitalized with gastrointestinal bleeding.Given bleeding type 3 by BARC (Bleeding Academic Research Consortium) associated with DAPT, it was decided to apply a strategy to de-escalate antiplatelet therapy under the control of platelet function testing (PFT) and genetic testing.In this case, replacement of ticagrelor with the weak P2Y12 receptor inhibitor clopidogrel was not possible as the patient appeared to be a carrier of the CYP2C19*2 polymorphism contributing to loss of function of the cytochrome P-450(CYP) enzyme.
Retrospective analysis of the prevalence of ischemic stroke and the appointment of anticoagulant therapy in patients with atrial fibrillation depending on the body mass index
Authors: Druzhilov M. A. , Kuznetsova T. Yu. , Druzhilova O. Yu. , Tsarkova M. K. , Gavrilov D. V. , Gusev A. V. 
Published: June 2023

Aim. To estimate the prevalence of ischemic stroke (IS) and the appointment of anticoagulant therapy in patients with atrial fibrillation (AF) depending on body mass index (BMI) as part of a retrospective analysis of big data from certain subjects of the Russian Federation using artificial intelligence technologies.Material and methods. The information was obtained from the Webiomed predictive analytics platform, which includes depersonalized data from electronic health records of patients in 6 Russian constituent, extracted using artificial intelligence technologies. Individuals with AF aged ≥18 years were selected with available data on BMI of 18,5-60,0 kg/m2 inclusive (n=56003; men, 41,0%; age, 67,4±14,5 years, CHA2DS2-VASc score, 3,4±1,8). The following BMI ranges were identified: 18,5-21,9 kg/m2, 22,0-24,9 kg/m2 (taken as a reference), 25,0-29,9 kg/m2, 30,0-34,9 kg/m2, 35,0-39,9 kg/m2 and 40,0-60,0 kg/m2. The indicators were analyzed in age ranges (≤64 years, 65-74 years, ≥75 years) separately among men and women.Results. Among men ≤64 years of age, patients with overweight and class 2 obesity were characterized by a significantly higher incidence of IS. Among women ≤64 years, a significantly higher frequency of IS was found in subgroups with overweight and class 1-3 obesity, while among women aged 65-74 years — in a subgroup with a BMI of 18,5-21,9 kg/m2. Patients aged ≥75 years showed an insignificant trend towards the maximum frequency of IS with a BMI of 18,5-21,9 kg/m2. A higher frequency of anticoagulant therapy prescription was found in subgroups with overweight and class 1-3 obesity; in most age and sex subgroups, the differences are significant. A significantly lower frequency of anticoagulant therapy prescription to persons ≥75 years of age with a BMI of 18,5-21,9 kg/m2 was noted.Conclusion. The study showed a significant BMI paradox in the context of the relationship between the frequency of IS and BMI value in patients with AF. A higher incidence of IS in persons ≤64 years of age with a BMI ≥25 kg/m2 compared with pa­tients with normal weight may be an additional argument for establishing an inde­pen­-dent prognostic role of obesity in the development of thromboembolic events in AF.
Factors determining adherence to anticoagulant therapy in patients with atrial fibrillation
Authors: Pevzner D. V. , Kostritsa N. S. , Galaeva L. M. , Merkulova I. A. , Dorogun O. B. , Krasnoperova E. V. , Komarov A. L. 
Published: June 2023

Aim. To identify risk factors for low adherence and develop a scale for its pre­diction. To evaluate the association of the predictive score with actual low adherence according to the 8-item Morisky Medication Adherence Scale, self-drug withdrawal, and adverse outcomes in patients with atrial fibrillation (AF).Material and methods. The study included patients with AF and a high risk of thromboembolic events according to the CHA2DS2-VASc scale, who were hospitalized from January 2011 to December 2017. Potential risk factors for non-adherence, selected from the literature, were tested in a multivariate regression analysis followed by the development of an adherence prediction scale. The asso­ciation of predicted low adherence with actual adherence was assessed.Results. The study included 199 patients. The analysis identified following predictors of low adherence: low income, history of bleeding, prior stroke, 4 positive responses to the adherence questionnaire, warfarin. Based on these predictors, a scale for predicting adherence was developed, while a threshold value of 3 points was identified (sensitivity, 90,2%, specificity, 98,4%). A significant association of low predicted adherence on the developed scale with actual adherence and adverse outcomes was demonstrated.Conclusion. We have developed a scale for predicting adherence to anticoagulant therapy, and also determined its threshold value. In case of a high risk of low adherence, clinicians should try to increase adherence in order to prevent comp­lications.
DX single-lead implantable cardioverter-defibrillator system with a floating atrial dipole: when, to whom, and why?
Authors: Prokopenko A. V. , Ivanitsky E. A. 
Published: June 2023

The article reflects information for cardiologists, cardiac surgeons, doctors pro­gramming implanted antiarrhythmic devices, employees and residents of the depart­ments of cardiology and cardiac surgery. Most often, we choose a model of an implantable cardioverter-defibrillator (ICD) strictly individually for each patient, based on the anamnesis characteristics, safety and highest efficiency of ICD systems offered on the market. With each new ICD model, manufacturing companies strive to minimize the number of implantable components and develop better algorithms to discriminate between atrial tachyarrhythmias and true ventricular tachyarrhythmias. However, the risk of inappropriate ICD therapy still remains high. Thus, attending physicians and cardiologists programming implantable antiarrhythmic devices often face difficulties in correcting ICD settings and planning further treatment of a patient with shocks caused by atrial tachyarrhythmias. The authors sought to form an idea about the features of a single-chamber ICD recording atrial potentials using a floating dipole, as well as the advantages of the DX system over classical single-chamber ICD systems, and to define a type of a patient for whom this implantable system would be the best choice preventing sudden cardiac death.
Review of 20-year results of ASCOT Legacy
Authors: Nagorny M. B. , Kuchmin A. N. 
Published: June 2023

The article presents the results of a 20-year follow-up of patients in the ASCOT Legacy study, indicating that antihypertensive and lipid-lowering therapy reduces mortality in patients with hypertension and high cardiovascular risk in the long term. In the group of patients treated with amlodipine compared with the β-blocker atenolol, there was a decrease in mean systolic and diastolic blood pressure (BP), as well as a long-term improve in the form of a decrease in the prevalence of cardiovascular events and mortality due to stroke. An important feature of therapy based on amlodipine was the reduction in BP variability. The article reflects the results of major studies that determine the possibility and effectiveness of early prescription of combined antihypertensive and lipid-lowering therapy.
Dezinformacja jako czynnik ryzyka w sytuacjach kryzysowych
Authors: Kaczmarek Krzysztof 
Published: June 2023

Fałszywe, szybko rozpowszechniające się informacje mogą modelować nastroje społeczne, wpływać na wyniki demokratycznych wyborów, powodować napięcia na arenie międzynarodowej, a nawet być przyczyną konfliktów zbrojnych. W przypadku zaistnienia sytuacji kryzysowej dezinformacja może być narzędziem wykorzystywanym w celu destabilizowania sytuacji wewnętrznej państwa. W takich okolicznościach poważne konsekwencje może mieć również dostęp osób niepowołanych do informacji niejawnych.
Współczesne urządzenia cyfrowe i zarządzające nimi systemy nie wymagają od przeciętnego użytkownika biegłej znajomości systemów informatycznych i umiejętności technicznych. Jednak rozwój nowoczesnych technologii determinuje potrzebę ciągłego uaktualniania wiedzy w tym zakresie. Dotyczy to w szczególności osób, które zajmują się, szeroko rozumianym, bezpieczeństwem państwa.