bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short‐term effects of SAFE early intervention approach in infants born preterm: A randomized controlled single‐blinded study
Authors: Apaydın Umut , Yıldız Ramazan , Yıldız Ayşe , Acar Şebnem Soysal , Gücüyener Kıvılcım , Elbasan Bülent 
Published: August 2023

AbstractObjectiveRecent literature suggests that goal‐oriented and family‐based interventions in enriched environment have a beneficial effect on neuromotor and cognitive development. We aimed to examine the short‐term effects of SAFE (Sensory strategies, Activity‐based motor training, Family collaboration, and Environmental Enrichment) early intervention approach on motor, cognitive, speech and language, and sensory development in preterm infants.MethodsThe study's sample population consisted of 24 preterm infants with corrected ages between 9 and 10 months. Infants in the control group participated in the family training program in accordance with the neurodevelopmental therapy principles (NDT). Infants in the treatment group were included in the family training program according to the principles of the SAFE Early Intervention Approach. Affordances in the Home Environment for Motor Development‐Infant Scale (AHEMD‐IS), Test of Sensory Functions in Infants (TSFI), Canadian Occupational Performance Measure (COPM), and Bayley Scales of Infant and Toddler Development III (Bayley III) were used to evaluate infants in both groups before and after 10 weeks of treatment (AHEMD‐IS). The Depression, Anxiety, Stress Scale Short Form was used to assess the parents’ mental health (DASS‐SF).ResultsThe interaction effects (time × group) revealed significant differences for Bayley‐III cognitive and language scores, TSFI total score, and AHEMD‐IS total score in favor of the SAFE group (p < .05). However, there were no differences in Bayley‐III motor composite score, COPM Performance score, and COPM Satisfaction score between the interaction effects (time × group) of the groups (p > .05).ConclusionsSAFE early intervention approach improved cognitive, speech and language, sensory outcomes and provide enriched home environment in all domains when compared to NDT‐based home program. SAFE is a promising novel early intervention approach for preterm infants.
A social identity approach to mental health help‐seeking behaviour in prisoners: A systematic review
Authors: Byrne Eimear , Bradshaw Daragh , Kerin Michelle , Pepe Irene 
Published: August 2023

AbstractPrevalence of mental health difficulties is demonstrably higher in prison rather than general populations. Compounding this, prisoners often display a reluctance to seek help, which can undermine rehabilitation. Recent years has seen an increase in studies exploring the factors involved in help‐seeking behaviours amongst prisoners. However, many of these studies come from different disciplines and do not use an overarching theoretical approach. Consequently, policymakers face a difficult task of synthesising and interpreting the findings from different perspectives. Using a deductive thematic analysis informed by a social identity framework, this current study aims to synthesis the existing research and provide an overarching theoretical perspective. Eleven databases were systematically searched for studies exploring help‐seeking behaviours in prisoners with mental health difficulties. Results indicate that prisons represent sites of enactment of a specific institutionalised identity that inhibits help‐seeking behaviour. Three themes relating to (1) the maintenance of positive group identity, (2) ‘us’ and ‘them’, and (3) inhibiting prison context were identified. This review provides an overarching coherent narrative of the experiences and perspectives of prisoners help‐seeking behaviour. This can enable policymakers develop theory‐based approaches to support this vulnerable cohort. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
The diagnostic dilemma in a patient with neuroleptic malignant syndrome during the COVID‐19 pandemic: A significant increase in acute phase reactants
Authors: Elyasi Forouzan , Zarghami Mehran , Fariborzifar Arghavan , Cheraghmakani Hamed , Shirzad Mahboobeh , Kazempour Feteme 
Published: August 2023

Key Clinical MessageIn some patients, neuroleptic malignant syndrome is accompanied significant high levels of erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP).AbstractNeuroleptic malignant syndrome (NMS) is an idiosyncratic life‐threatening adverse reaction and usually triggered in response to antipsychotic drugs. In addition, leukocytosis and increased muscle enzymes levels (especially creatine phosphokinase) are observed in NMS. In addition, a transient increase in different types of acute phase reactants in NMS has been mentioned. This article describes a woman treated with haloperidol, perphenazine, escitalopram, and alprazolam because she developed catatonic symptoms after psychological stress. She suffered from NMS symptoms and had elevated CRP and ESR levels, among other signs and symptoms. Given the COVID‐19 pandemic and reports of co‐occurrence of catatonia and NMS and COVID‐19 and elevated erythrocyte sedimentation rate (ESR) and C‐reactive protein (CRP), this patient was a diagnostic dilemma. After consultation with the consultation‐liaison psychiatry units, she was managed adequately with electroconvulsive therapy and lorazepam.
Synthesis and Characterization of 15N‐Labeled Poly(sulfur nitride) in Bulk and in Superconductor Composites
Authors: Kressler Jörg , Radicke Julian , Busse Karsten , Amsharov Konstantin , Golitsyn Yury , Reichert Detlef , Syrowatka Frank , Hasan Nazmul 
Published: August 2023

Abstract15N‐labeled tetrasulfur tetranitride (S415N4) was synthesized by reacting S2Cl2 with 15NH3. The reaction was finalized with 14NH3. The successful labeling was confirmed by solution 15N nuclear magnetic resonance (NMR) spectroscopy. S415N4 was used for the synthesis of poly(sulfur nitride) S15Nx via the intermediate species of S2N2. It was a topochemical polymerization in the solid state. The isotope ratio in the labeled polymer was obtained by laser deposition ionization time‐of‐flight mass spectroscopy. Solid‐state 15N NMR spectroscopy of S15Nx indicates that at least three different chemical environments for 15N atoms are present in the crystals. Finally, SNx was polymerized in the presence of two other superconductors, MgB2 and yttrium barium copper oxide (YBCO), which demonstrates the capability of SNx for grain boundary engineering.
Synthesis of L‐Hexopyranosyl Fluorides Enabled by Radical Decarboxylative Fluorination: Assembly of a Pentasaccharide Repeating Unit Corresponding to Extracellular Polysaccharide S‐88
Authors: Qiao Zhi , Li Dongwei , Gao Jingru , Hou Zijiao , Yan Ningjie , Song Ni , Wang Peng , Li Ming 
Published: August 2023

Comprehensive SummaryL‐Hexoses are key components of many biologically relevant natural products and pharmaceuticals. As rare sugars, L‐hexoses are not readily obtained from natural sources. Access to L‐hexose building blocks from commercially available and inexpensive D‐sugars is highly desirable from the viewpoints of organic synthesis and drug discovery. As demonstrated by the convenient preparation of L‐glucosyl, L‐galactosyl, and L‐mannosyl fluorides from readily available β‐D‐C‐glucosyl, β‐D‐C‐mannosyl, and β‐D‐C‐galactosyl derivatives, we describe a novel and efficient approach to the demanding L‐glycosyl fluorides. The transformation features the installation of anomeric hydroxymethyl group under mild conditions and C1‐to‐C5 switch of sugar rings through radical decarboxylative fluorination of uronic acids. The power of this protocol is highlighted by the first assembly of a pentasaccharide repeating unit of Pseudomonas ATCC 31554 extracellular polysaccharide (S‐88). This synthesis relies on the efficient extension of sugar chain at the sterically hindered hydroxy group and the facile introduction of L‐mannosyl unit using L‐mannosyl fluoride as glycosylating agent. The methods developed in this work would provide new tools to the arsenal of synthesis of L‐sugar building blocks and of assembly of glycans containing L‐sugar moieties.
Tunable Gas‐Gas Reactions through Nanobubble Pathway
Authors: Zhang Ruiyi , Gao Ya , Chen Lan , Li Dexing , Ge Guanglu 
Published: August 2023

AbstractCombustible gas‐gas reactions usually do not occur spontaneously upon mixing without ignition or other triggers to lower the activation energy barrier. Nanobubbles, however, could provide such a possibility in solution under ambient conditions due to high inner pressure and catalytic radicals within their boundary layers. Herein, a tunable gas‐gas reaction strategy via bulk nanobubble pathway is developed by tuning the interface charge of one type of bulk nanobubble and promoting its fusion and reaction with another, where the reaction‐accompanied size and number concentration change of the bulk nanobubbles and the corresponding thermal effect clearly confirm the occurrence of the nanobubble‐based H2/O2 combustion. In addition, abundant radicals can be detected during the reaction, which is considered to be critical to ignite the gas reaction during the fusion of nanobubbles in water at room temperature. Therefore, the nanobubble‐based gas‐gas reactions provide a safe and efficient pathway to produce energy and synthesize new matter inaccessible under mild or ambient conditions.
Photocatalytic Water Splitting Driven by Surface Plasmon Resonance
Authors: Li Hao , Wang Shengyang , Chi Haibo , Li Can 
Published: August 2023

AbstractSurface plasmon resonance (SPR) in metals results in unique optical properties and photoelectric functions, which are helpful for light harvesting in photocatalysis. Additionally, the plasmon‐associated charge transfer process gives a complementary platform to understand the charge dynamics at a fundamental level. This Review focused on the recent developments of water splitting by plasmonic metals/semiconductor photocatalysts. Firstly, the basic characteristics of SPR and the plasmon‐enhanced photocatalysis mechanisms including plasmon resonance energy transfer and interfacial charge transfer are introduced, highlighting the recent understanding of the plasmonic electron‐hole separation, distribution, and the reaction sites for water splitting. Then, advances in the strategies to improve the quantum efficiency of plasmon‐induced water splitting are summarized by considering modulation in metals, interface contacts, and bulk properties of semiconductors. Finally, we discuss future prospects in the development of high‐efficiency plasmonic metal/semiconductor photocatalysts for water splitting.
Development and validation of Kompetitive allele‐specific PCR (KASP) markers for bacterial blight resistant locus BB‐13 in Upland cotton (Gossypium hirsutum L.)
Authors: Pettit Nicole , Gowda Satyanarayna Anjan , Shrestha Navin , Harris Taylor , Bart Rebecca , Bourland Fred , Brown‐Guedira Gina , Jones Don C. , Kuraparthy Vasu 
Published: August 2023

AbstractCotton bacterial blight (CBB), caused by the pathogen Xanthomonas citri subsp. malvacearum (Xcm), can inflict significant damage to cotton (Gossypium hirsutum L.) production. Previously, we identified and mapped the broad‐spectrum CBB‐resistant locus BB‐13 on the long arm of chromosome D02 using array‐based single nucleotide polymorphisms (SNPs). In the current study, linked SNPs were converted into easily assayable Kompetitive Allele‐Specific PCR (KASP) markers to enable efficient detection and marker‐assisted selection of alleles at the BB‐13 locus. The KASP marker's efficiency in detecting the BB‐13 resistant gene was validated using an Upland cotton diversity panel of 72 accessions phenotyped with Xcm race 18. The KASP marker NCBB‐KASP4, derived from the CottonSNP63K array‐based marker i25755Gh that is closely associated with BB‐13, predicted the CBB response phenotypes with an error rate of 4.17% in the diversity panel. Additionally, two independent biparental recombinant inbred line populations segregating for resistance to Xcm race 18 were used for KASP marker validation and to test their utility in detecting the presence of the BB‐13 locus in the resistant accession CABD3CABCH‐1‐89. NCBB‐KASP4, validated across breeding populations and broad germplasm, is a reliable KASP marker for detection and testing of BB‐13 locus in cotton. Further, diagnostic array‐based SNP marker i25755Gh's allele pattern and the potential CBB response is described for 875 Gossypium accessions. These SNP‐based phenotypic predictions for 875 accessions along with disease response phenotypes to Xcm race 18 for 253 accessions provide a reference for CBB resistance in diverse cotton germplasm in the United States.
“Copy number alteration” as the sole molecular finding of a Thyroseq test is more commonly seen in Hurthle cell neoplasms
Authors: Kim Teresa H. , Rodriguez Erika F. , Lim Douglas , Moatamed Neda A. 
Published: August 2023

AbstractBackgroundTo better understand the molecular alterations associated with Hurthle cell lesions of the thyroid, we retrospectively reviewed the association of clonal DNA copy number alterations (CNAs) with fine needle aspiration (FNA) cytomorphology and surgical follow‐up.MethodsHurthle cell type (HCT) and non‐Hurthle cell type (NHCT) thyroid FNAs that were classified according to the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) as atypia of undetermined significance (AUS) and suspicious for a follicular neoplasm (SFN) with corresponding molecular testing performed by ThyroSeq v3 genomic classifier were compared to surgical follow‐up.ResultsA total of 54 thyroid FNA cases were identified, distributed among the following categories: AUS‐HCT (n = 15, 27.8%), SFN‐HCT (n = 11, 20.4%), AUS‐NHCT (n = 19, 35.2%), and SFN‐NHCT (n = 9, 16.6%). The lesions classified as AUS‐HCT and SFN‐HCT showed a higher prevalence of CNAs (n = 10/26; 38.5%) compared to their NHCT counterparts (n = 3/28; 10.7%) (p < .03). Of the 42 patients (77.8%) with surgical follow‐up, CNAs were more often seen in benign (n = 10/26, 38.5%) than malignant conditions (n = 1/16, 6.3%) (p < .03). CNAs were encountered in more lesions with Hurthle cell features on histologic examination (n = 8/14, 57.1%) than those without (n = 3/28, 10.7%) (p < .002). The presence of CNAs alone was seen only in benign adenomas and more commonly with Hurthle cell features (n = 5/7, 71.4%).ConclusionIn this study, CNAs were associated with Hurthle cell morphology on thyroid FNA and benign adenomas upon surgical follow‐up. Therefore, if the only finding of a positive ThyroSeq v3 GC result is a CNA, conservative management can be considered if clinically indicated.
Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases
Authors: Liu Jinyao , Liu Shuang , Yu Mingyue , Li Jianing , Xie Zunxuan , Gao Boyang , Liu Yuyan 
Published: August 2023

AbstractCatalpol is a kind of iridoid glucoside, widely found in a variety of plants, mostly extracted from the rhizome of the traditional medicinal herb rehmanniae. It has various biological activities such as anti‐inflammatory, antioxidant, and antitumor. The anti‐inflammatory effects of catalpol have been demonstrated in a variety of diseases, such as neurological diseases, atherosclerosis, renal diseases, respiratory diseases, digestive diseases, bone and joint diseases, eye diseases, and periodontitis. The purpose of this review is to summarize the existing literature on the anti‐inflammatory effects of catalpol in a variety of inflammatory diseases over the last decade and to focus on the anti‐inflammatory mechanisms of catalpol.
Remotely sensed environmental measurements detect decoupled processes driving population dynamics at contrasting scales
Authors: Harder Avril M. , Sundaram Mekala , Narine Lana L. , Willoughby Janna R. 
Published: August 2023

AbstractThe increasing availability of satellite imagery has supported a rapid expansion in forward‐looking studies seeking to track and predict how climate change will influence wild population dynamics. However, these data can also be used in retrospect to provide additional context for historical data in the absence of contemporaneous environmental measurements. We used 167 Landsat‐5 Thematic Mapper (TM) images spanning 13 years to identify environmental drivers of fitness and population size in a well‐characterized population of banner‐tailed kangaroo rats (Dipodomys spectabilis) in the southwestern United States. We found evidence of two decoupled processes that may be driving population dynamics in opposing directions over distinct time frames. Specifically, increasing mean surface temperature corresponded to increased individual fitness, where fitness is defined as the number of offspring produced by a single individual. This result contrasts with our findings for population size, where increasing surface temperature led to decreased numbers of active mounds. These relationships between surface temperature and (i) individual fitness and (ii) population size would not have been identified in the absence of remotely sensed data, indicating that such information can be used to test existing hypotheses and generate new ecological predictions regarding fitness at multiple spatial scales and degrees of sampling effort. To our knowledge, this study is the first to directly link remotely sensed environmental data to individual fitness in a nearly exhaustively sampled population, opening a new avenue for incorporating remote sensing data into eco‐evolutionary studies.
A validated and optimized environmentalDNAandRNAassay to detect Arctic grayling (Thymallus arcticus)
Authors: Misutka Melissa D. , Glover Chris N. , Brush Micah , Goss Greg G. , Veilleux Heather D. 
Published: August 2023

AbstractArctic grayling (Thymallus arcticus) is a salmonid fish of significant conservation value. However, conservation efforts are hindered by a lack of fundamental information regarding details such as current population distribution, migratory patterns, and natal habitats. In the current study, we designed, optimized, and field‐ and laboratory‐validated an environmental DNA (eDNA) and environmental RNA (eRNA) assay for Arctic grayling biomonitoring. Using an in silico approach, a robust species‐specific eDNA assay was generated, and filtering and extraction protocols were optimized for maximal eDNA yield. A Preserve, Precipitate, Lyse, Precipitate, and Purify (PPLPP) extraction method generated 70‐fold higher eDNA yields than a column‐based approach. Species‐specificity relative to co‐occurring salmonid fish was validated, and no significant amplification was noted for rainbow trout, brook trout, or mountain whitefish. Shedding rates of eDNA were around eight to nine times higher than those of eRNA, although the two types of nucleic acids decayed at similar rates. Shedding and decay rates were subsequently used to build detection probability models that account for pool size and water exchange rates. These data indicate that eDNA and eRNA are detectable in pools up to 32,500 m3in volume and with water flow of less than 0.5 m3s−1when an Arctic grayling is present. This knowledge can be implemented when designing field sampling strategies. Finally, the assay successfully amplified Arctic grayling eDNA from field‐collected samples, with signal strength indicating preferred Arctic grayling habitat or conditions that favored the concentration and retention of eDNA.
One‐Step Synthesis of Cyclobutene‐Annulated Fullerenes through a Cascade Reaction
Authors: Yamada Michio , Uokawa Yuta , Sasaki Shino , Iha Naohiro , Hashimoto Yoshihisa , Nagasaki Yuya , Maeda Yutaka , Suzuki Mitsuaki 
Published: August 2023

AbstractThe physicochemical properties of fullerene‐based materials typically vary depending on the type and mode of addition of functional groups; therefore, developing fullerene derivatives with novel structures is imperative for further progress in materials science. In this study, we develop an efficient one‐step strategy for synthesizing cyclobutene‐annulated fullerene derivatives (cyclobutenofullerenes) and characterize their electronic properties. Despite the steric strain, cyclobutenofullerenes can be easily prepared via a one‐step reaction of C60 with a secondary propargylic phosphate. Structural analysis of the reaction intermediates suggests that the cascade reaction proceeds through a formal [2+2] cycloaddition of C60 with an allene, caused by the 1,3‐migration of the propargylic phosphate, followed by an additional 1,3‐migration and the subsequent 1,2‐elimination of the phosphodiester moiety.
Direct Trifluoromethylselenolation and Fluoroalkylselenolation of C−H Bonds: Recent Advances in Reagents Development and Reactions
Authors: Gao Yan , Xiao Rui , Zhang Shangbiao , Wang Yanan , Yuan Zheliang 
Published: August 2023

AbstractDue to their high lipophilicity and strong electron‐withdrawing property, more and more attention has been paid to introducing trifluoromethylseleno and fluoroalkylseleno moieties into organic molecules. In this short review, we categorize the synthesis of compounds that combine selenium and fluorinated moieties into two main types: trifluoromethylselenolation (CF3Se) and fluoroalkylselenolation (RfSe, except CF3Se). This review aims to provide a summary of the recent advances in direct C−H trifluoromethylselenolation and fluoroalkylselenolation from the synthesis of trifluoromethylselenolation and fluoroalkylselenolation reagents to their application. Based on the method of how the RfSe group was introduced, the main content is divided into three parts: transition‐metal‐free reactions, transition‐metal‐mediated/catalyzed reactions and photo‐catalyzed reactions. The general substrate scope, mechanism and limitations would also be discussed so that we hope the review will serve as an inspiration for further research in this appealing research field.
PMS2 or PMS2CL? Characterization of variants detected in the 3′ of the PMS2 gene
Authors: Bouras Ahmed , Lefol Cedrick , Ruano Eric , Grand‐Masson Chloé , Wang Qing 
Published: August 2023

AbstractPMS2 germline pathogenic variants are one of the major causes for Lynch syndrome and constitutional mismatch repair deficiencies. Variant identification in the 3′ region of this gene is complicated by the presence of the pseudogene PMS2CL which shares a high sequence homology with PMS2. Consequently, short‐fragment screening strategies (NGS, Sanger) may fail to discriminate variant's gene localization. Using a comprehensive analysis strategy, we assessed 42 NGS‐detected variants in 76 patients and found 32 localized on PMS2 while 6 on PMS2CL. Interestingly, four variants were detected in either of them in different patients. Clinical phenotype was well correlated to genotype, making it very helpful in variant assessment. Our findings emphasize the necessity of more specific complementary analyses to confirm the gene origin of each variant detected in different individuals in order to avoid variant misinterpretation. In addition, we characterized two PMS2 genomic alterations involving Alu‐mediated tandem duplication and gene conversion. Those mechanisms seemed to be particularly favored in PMS2 which contribute to frequent genomic rearrangements in the 3′ region of the gene.