bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Hallucination Proneness and Sensory Resolution on Prior Biases in Human Perceptual Inference of Time Intervals
Authors: Duhamel Emeline , Mihali Andra , Horga Guillermo 
Published: June 2023

Bayesian models of perception posit that percepts result from the optimal integration of new sensory information and prior expectations. In turn, prominent models of perceptual disturbances in psychosis frame hallucination-like phenomena as percepts excessively biased toward perceptual prior expectations. Despite mounting support for this notion, whether this hallucination-related prior bias results secondarily from imprecise sensory representations at early processing stages or directly from alterations in perceptual priors—both suggested candidates potentially consistent with Bayesian models—remains to be tested. Using modified interval timing paradigms designed to arbitrate between these alternative hypotheses, we show in human participants (16 females and 24 males) from a nonclinical population that hallucination proneness correlates with a circumscribed form of prior bias that reflects selective differences in weighting of contextual prior variance, a prior bias that is unrelated to the effect of sensory noise and to a separate index of sensory resolution. Our results thus suggest distinct mechanisms underlying prior biases in perceptual inference and favor the notion that hallucination proneness could reflect direct alterations in the representation or use of perceptual priors independent of sensory noise.SIGNIFICANCE STATEMENTCurrent theories of psychosis posit that hallucination proneness results from excessive influence of prior expectations on perception. It is not clear whether this prior bias represents a primary top-down process related to the representation or use of prior beliefs or instead a secondary bottom-up process stemming from imprecise sensory representations at early processing stages. To address this question, we examined interval timing behaviors captured by Bayesian perceptual-inference models. Our data support the notion that excessive influence of prior expectations associated with hallucination propensity is not directly secondary to sensory imprecision and is instead more consistent with a primary top-down process. These results help refine computational theories of psychosis and may contribute to the development of improved intervention targets.
Human Neuralized is a novel tumour suppressor targeting Wnt/β‐catenin signalling in colon cancer
Authors: Yi Joo Mi , Kang Tae‐Hong , Han Yu Kyeong , Park Ha Young , Yang Ju Hwan , Bae Jin‐Han , Suh Jung‐Soo , Kim Tae‐Jin , Kim Joong‐Gook , Cui Yan‐Hong , Suzuki Hiromu , Kumegawa Kohei , Kim Sung Joo , Zhao Yi , Park In Ja , Hong Seung‐Mo , Chung Joon‐Yong , Lee Su‐Jae 
Published: June 2023

AbstractWhile there is growing evidence that many epigenetically silenced genes in cancer are tumour suppressor candidates, their significance in cancer biology remains unclear. Here, we identify human Neuralized (NEURL), which acts as a novel tumour suppressor targeting oncogenic Wnt/β‐catenin signalling in human cancers. The expression of NEURL is epigenetically regulated and markedly suppressed in human colorectal cancer. We, therefore, considered NEURL to be a bona fide tumour suppressor in colorectal cancer and demonstrate that this tumour suppressive function depends on NEURL‐mediated oncogenic β‐catenin degradation. We find that NEURL acts as an E3 ubiquitin ligase, interacting directly with oncogenic β‐catenin, and reducing its cytoplasmic levels in a GSK3β‐ and β‐TrCP‐independent manner, indicating that NEURL‐β‐catenin interactions can lead to a disruption of the canonical Wnt/β‐catenin pathway. This study suggests that NEURL is a therapeutic target against human cancers and that it acts by regulating oncogenic Wnt/β‐catenin signalling.
Online Temporary Learning Groups in Higher Education – Interactions, Compensation, and Maximisation of Achievements in an Israeli Case Study
Authors: Ben-Shalom Uzi , Hajaj Chen , Davidovitch Nitza , Berger Corinne 
Published: June 2023

Thesis. This article provides an analysis of online social interactions in two online Temporary Learning Groups (TLG) and their correlates with both pre-admissions scores and academic achievements.
Concept. The function of Social Networking Systems (SNS) use on academic achievements is most often indirectly assessed through surveying attitudes of students and teachers. Contrary to this approach, we directly assessed the content on a TLG and paired it with objective admission scores and academic achievements.
Results and conclusion. The results reveal that the content of the discussions on the TLGs is practical, immediate, and focuses on the allocation of information required for academic achievements. The users of the TLGs are usually students with lower admission scores and academic achievements. They use these platforms as a compensating mechanism to improve their achievements. In addition, some of the TLG users serve as maximising agents of other students’ achievements. TLGs’ implications for teaching, class-attendance and level of schooling must be recognised by teachers.
Originality. While researchers focus on the presence of SNSs in class and its hampering of schooling by multitasking the effect of TLG activity must also be addressed.
El encuentro del nosotras y nosotros a partir del lenguaje y la voz. Sobre la teoría y método feminista de María Lugones
Authors: Vargas Vargas Karla 
Published: June 2023

Este trabajo sistematiza algunos de los aportes de María Lugones (1944-2020) y se dan a conocer, interpretan y discuten aspectos que permiten comprender la crítica que ella presenta a la teoría y método feministas, a partir del análisis del artículo de Lugones y Elizabeth V. Spelman publicado en 1983, titulado: Have we got a theory for you! Feminist theory, cultural imperialism and the demand for ‘the woman’s voice’, así como Structure/Antistructure and Agency Under Oppression (1990), Playfulness, "World"-Travelling, and Loving Perception (1987), y Purity, Impurity, and Separation (1994). El énfasis de este artículo recae en el examen de la voz y su silenciamiento como forma de opresión hacia las mujeres y otras poblaciones vulnerabilizadas. Lo anterior, se considera una de las simientes de la interseccionalidad que la autora mantiene en sus escritos, como instrumento más abarcador del qué, cómo, quién, para qué, porqué de la opresión, que viven los seres humanos, particularmente las mujeres y que, en esta ocasión, ella relaciona específicamente con el imperialismo cultural.
Imipenem resistance associated with amino acid alterations of the OprD porin in Pseudomonas aeruginosa clinical isolates
Authors: Nazari Maryam , Ahmadi Hadi , Hosseinzadeh Shahnaz , Sahebkar Amirhossein , Khademi Farzad 
Published: June 2023

AbstractGlobally, the spread of carbapenem-resistant strains has limited treatment options for multidrug-resistant (MDR) Pseudomonas aeruginosa infections. This study aimed to determine the role of point mutations as well as the expression level of the oprD gene in the emergence of imipenem-resistant P. aeruginosa strains isolated from patients referred to Ardabil hospitals. A total of 48 imipenem-resistant clinical isolates of P. aeruginosa collected between June 2019 and January 2022 were used in this study. Detection of the oprD gene and its amino acid alterations was performed using the polymerase chain reaction (PCR) and DNA sequencing techniques. The expression level of the oprD gene in imipenem-resistant strains was determined using the real-time quantitative reverse transcription PCR (RT-PCR) method. All imipenem-resistant P. aeruginosa strains were positive for the oprD gene based on the PCR results, and also five selected isolates indicated one or more amino acid alterations. Detected amino acid alterations in the OprD porin were Ala210Ile, Gln202Glu, Ala189Val, Ala186Pro, Leu170Phe, Leu127Val, Thr115Lys, and Ser103Thr. Based on the RT-PCR results, the oprD gene was downregulated in 79.1% of imipenem-resistant P. aeruginosa strains. However, 20.9% of strains showed overexpression of the oprD gene. Probably, resistance to imipenem in these strains is associated with the presence of carbapenemases, AmpC cephalosporinase, or efflux pumps. Owing to the high prevalence of imipenem-resistant P. aeruginosa strains due to various resistance mechanisms in Ardabil hospitals, the implementation of surveillance programs to reduce the spread of these resistant microorganisms along with rational selection and prescription of antibiotics is recommended.
Stabilité du méthoxyflurane au froid
Authors: LEROULLEY D. , TAUDON N. , MILLIAT G. , ROEHRIG B. , LAUER J. , TOZZA C. , CABANE D. , BOURRILHON C. 
Published: June 2023

L’antalgie nécessaire et suffisante est un des objectifs pour une prise en charge optimale du traumatisé en milieu périlleux et montagnard. Dans ce cadre, l’administration per os d’antalgiques n’est souvent pas suffisante et une analgésie par voie veineuse engendre des contraintes techniques et de fiabilité. La revue de la littérature ainsi que les observations lors d’expéditions militaires en milieu arctique tendent à montrer que certaines molécules d’urgence sont dégradées lors d’une exposition à la congélation ou aux cycles congélation/décongélation. En outre, les perspectives stratégiques en milieu arctique ou polaire font envisager une adaptation du matériel composant la TIC 08. Le méthoxyflurane semble être une alternative possible à la morphine sous-cutanée en dosette unique. Nous avons proposé de mesurer la quantité résiduelle de méthoxyflurane par spectrométrie de masse et chromatographie en phase gazeuse dans trois conditions : température ambiante, congélation pendant 3 semaines et des cycles de congélation/décongélation. Le critère de jugement principal est une baisse de plus de 10 % de sa quantité par rapport à la concentration théorique [10 ng/ml]. Après 15 mesures, les concentrations mesurées sont toutes supérieures à 90 % de la concentration théorique de la solution mesurée à l’exception d’une. Les résultats montrent donc une absence de dégradation du méthoxyflurane vis-à-vis du stockage à -20 °C ou d’une séquence de congélation/décongélation. Cette étude montre la stabilité du méthoxyflurane au froid intense.
Carbetocin versus Oxytocin in placental separation and postpartum haemorrhage in caesarean section-comparative observational study
Authors: Bashir Khushbu , Sabha Madieha 
Published: June 2023

Background: Carbetocin and oxytocin are indicated for the prevention of postpartum haemorrhage (PPH) due to uterine atony. Carbetocin is a newer analogue of oxytocin with longer half life and more heat stable. PPH can be effectively reduced by the prophylactic use of uterotonics. The aims of the present study were to compare effects of oxytocin and carbetocin in separation of placenta, in controlling the blood loss and the additional uterotonic needed in caesarean section (CS) at high risk of primary PPH.
Methods: Women in the carbetocin group (group A) received a bolus of 100 µg IV; women in the control group (group B) received 20 IU of oxytocin in 1000 ml of 0.9% NaCl solution IV (150 mL/ hour). The efficacy of drugs in controlling blood loss was evaluated. Also, the haemodynamic effects and the need for additional uterotonic agents was compared. In addition, we compared the drop in haemoglobin level, the placental separation, the uterine tone.
Results: Both drugs produce hypotension but the effect was greater in oxytocin group. Placental separation was seen early in oxytocin group. Uterine tone was attained earlier in oxytocin group however the tone was maintained persistently in carbetocin group. Additional uterotonic agents were needed in the oxytocin group (46% vs 0%, p=0.05).
Conclusions: A single injection of carbetocin appears to be more effective than a continuous infusion of oxytocin to maintain sustained and adequate uterine tone and to prevent the PPH. However, there is delayed placental separation and delayed attainment of adequate uterine tone after use of carbetocin.
Estratégias de Enfrentamento Utilizadas por Trabalhadores em Situação de Desemprego: Uma Revisão Integrativa
Authors: Carlotto Mary Sandra , Neumann Gabriela 
Published: June 2023

O desemprego se refere às pessoas com idade para trabalhar, acima de 14 anos, que não estão trabalhando, mas estão disponíveis e tentam encontrar trabalho. O trabalhador em situação de desemprego procura meios para sair de tal situação, recorrendo a estratégias de enfrentamento. O presente estudo de revisão narrativa realizou uma busca nas bases de dados Scielo Brasil, Pepsic, BVS, Pubmed, Lilacs e Redalyc com os termos desemprego e coping e desemprego e estratégias de enfrentamento. Após a busca realizada foram identificados inicialmente 43 artigos. Destes 34 foram excluídos por não se enquadrarem nos critérios de inclusão e exclusão. Dessa forma, a revisão final contemplou um total de 09 artigos que foram analisados de acordo com as seguintes categorias: ano de publicação; periódico; amostra; método, instrumento utilizado, e, principais resultados. Resultados indicaram maior uso de estratégias individuais para lidar com a situação de desemprego. Para as lacunas identificadas sugerem-se novos estudos com uma maior atenção à diversificação de delineamentos e técnicas de coleta de dados.
Studi Literatur: Pentingnya Pembelajaran Berdiferensiasi di Era Kurikulum Merdeka untuk Meningkatkan Hasil Belajar Peserta Didik
Authors: Insani Alamia Haque , Munandar Kukuh 
Published: June 2023

The independent curriculum implements a new paradigm of learning, one of which is independent learning. Independent learning is an approach for students to be able to choose lessons according to their interests and needs. The needs and interests of each student vary and the teacher can accommodate this diversity by implementing differentiated learning. Learning that fits the needs of students through differentiated learning can improve student learning outcomes. The purpose of this research is to review the importance of differentiated learning in the independent curriculum era to improve student learning outcomes. Based on a literature review, the results of the study show that there is an effect of differentiated learning on improving student learning outcomes. Improvement of learning outcomes as a form of implementing one or more aspects of differentiation. The differentiation aspect consists of content, process, product, and learning environment differentiation.
Hurricanes Don’t Care About Your Flow Assurance Procedures: A Case History on How Facility Damage Provided a Natural Experiment to Validate Continuous Improvements in Paraffin Inhibitor Stability Qualification
Authors: Mazzeo Claudia , Garan Ron , Razavi Syed , Little Charles 
Published: June 2023

Abstract
The importance of understanding the conditions under which a product maintains stability and acceptable physical properties was highlighted in August of 2021 when Hurricane Ida disrupted operations across many Gulf of Mexico production facilities. The genesis of the storm was poorly forecasted (Beven et al. 2022) and the forecasted intensity and path of this storm dramatically shifted in the days before landfall. Transportation logistics constraints around these uncertainties resulted in operators not having full control over the timelines of evacuation and in some cases, needing to accelerate shut-in procedures to ensure the safety of evacuating personnel.
One instance of this scenario resulted in a facility being evacuated before the crew was able to initiate umbilical maintenance flushing or depressurization of a deepwater subsea paraffin inhibitor (PI) umbilical. Damage to the facility during the storm resulted in a loss of power and hydraulic control for several months in which the product was stagnant and subjected to the seafloor temperature of 4°C and approximately 4,500 psi. A total of 160 days elapsed between the unplanned shut-in and field restart. This unfortunate situation did, however, have a silver lining.
The PI in use on the facility had been developed and qualified under a series of tests developed and implemented between 2015 and 2018 which supplemented the recommendations of API 17TR5 and API 17TR6 with the aim of more effectively screening PI chemistries for stability under edge case field conditions. Until the shut-in caused by Hurricane Ida, none of the PI products developed under this augmented methodology had been exposed to conditions and durations extreme enough to fully validate the efficacy of the changes.
This paper describes the rationale behind the modifications made to the qualification process, specific recommendations related to the evaluation of time-dependent product gelation with an HP Viscometer and evaluation of thermal cycling impacts through a more severe dynamic flow loop, as well as a description of 2 case histories related to the product instability which initiated this project and the successful field test which validated its efficacy in the real world.
Cementing Geothermal Wells with Adapted Cementitious Materials: Formulation and Additives Selection
Authors: Cadix Arnaud , Hernandez Mario , Blaizot Dylan , Thant KyiPhay 
Published: June 2023

Abstract
Development of Geothermal reservoirs targeting steam production for electricity generation requires to implement specific subsurface infrastructure able to withstand aggressive conditions for extended number of years. Elevated temperature from 150°C to above 300°C are systematically encountered and the presence corrosive gases (carbon dioxide or hydrogen sulfide) brings on another challenge for the zonal isolation and asset integrity.
In order to ensure wells integrity cement sheath shall seal tightly rock and steel casing. As many studies demonstrated in the past, ordinary Portland cement would lose its mechanical performance and barrier properties when exposed to high temperatures and acidic environments. Thus, modified cements with adapted mineral compositions have been promoted for the specific use in Geothermal wells construction.
As based on different mineralogy, these blends present better chemical resistance and mechanical durability when compared to ordinary Portland cement. Therefore, organic additives such as retarder, fluid loss or gas migration control additives as well as suspension aids would have to be appropriately selected from their working mechanism to be used in Geothermal blends.
The scope of this study is investigate a set of additives, which would be "compatible" with Geothermal jobs and ensure good cement placement.
This paper summarizes first some key aspects of the Geothermal blends versus ordinary Portland cement in terms of physico-chemical behavior as well as a few primary additives instrumental to a successful cementing job.
Based on this background information, performance of the most promising candidates were assessed within our equipment temperature limitations with Geothermal blends using conventional API performance test protocols.
From this study, it was concluded that some fluid loss additives with working mechanism based on adsorption on mineral particles could suffer from competitive adsorption from high temperature retarders. On the other hand, structured copolymer with strongly adsorbing moieties show consistently satisfactory performance. In addition, styrene butadiene latexes with adapted stabilization packages can also represent good option to run HPHT cementing jobs in corrosive environments.
Field Application of a New Method for Bicarbonate Alkalinity Measurement
Authors: Liu Ya , Chao Kung-Po , Russek Jeffrey , Leontieff Andre 
Published: June 2023

Abstract
Accurate bicarbonate measurement is crucial in carbonate scales prediction. A common method for bicarbonate determination is through subtracting total alkalinity with carboxylates, but the measurement of carboxylates is time consuming and not applicable in the field. Since bicarbonate is hard to preserve in field brines, a field applicable method for bicarbonate detection was developed in a previous study. It was named the "head space method". The method is based on the head space pressure change due to carbon dioxide (CO2) releasing from test brine by adding strong acid to convert bicarbonate to CO2. This study is to further validate the method with synthetic and field brines and to investigate potential limitations. Based on the the tests of this study, the head space method can measure bicarbonate accurately without interference by the presence of carboxylates. In both synthetic and field brine analysis, the bicarbonates measured by head space method generally matched with the calculated bicarbonates through total alkalinity and total carboxylates. A case study further validated the accuracy of the head space method on bicarbonate determination. Moreover, this method is fast with low costs. Each sample analysis takes about 5 minutes. The capital cost of head space method equipment is less than 1,000 dollars. A limitation of the head space method identified that it is not applicable for high sulfide brines or brines with &lt; 100 mg/L bicarbonate. Desipite the limitation, this low-cost bicarbonate detection method is fast, accurate, and applicable in the field, and able to provide instant bicarbonate monitoring in produced water in many cases.
Value-Added Decarbonatization via Carbon Dioxide Conversion to Cyclic Carbonates
Authors: Wang Xiaofeng , Carrasco Analette , Murugesan Sankaran , Blackwell Catherine , Ugono Onome , Nugent Douglas , Roberts Corby , Weers Jerry 
Published: June 2023

Abstract
Carbon capture, utilization, and storage (CCUS) represents one of the key contributors to decarbonization. CCUS hubs that take gases from industrial systems as chemical, power, gas producers, and oil refineries have become the energy industry’s preferred way to combat climate warming. Avenues to utilize the captured CO2 are becoming an attractive area of research. One promising route is through the production of high-value and sustainable products where it can be directly used as a raw material. This paper highlights the direct conversion of CO2 to valuable chemical products such as cyclic organic carbonates in route to sustainable solutions, less energy intensive manufacturing process and lower carbon footprint products. An efficient synthesis process that combines the use of a low-cost, nontoxic, single catalyst system under mild process conditions was developed. The resulting process reported herein was successfully scaled up to nearly quantitative conversion and &gt; 98% purity. Reaction efficiency was achieved by optimizing parameters and can be extended to a variety of cyclic organic carbonates.