bluuebunny/crossref_metadata_2025_split huggingface dataset:
The assessment of pathological response to neoadjuvant chemotherapy in muscle-invasive bladder cancer patients with DCE-MRI and DWI: a systematic review and meta-analysis
Authors: Zong Ruilong , Ma Xijuan , Shi Yibing , Geng Li 
Published: September 2023

Objective:
The purpose of this meta-analysis was to determine the value of dynamic contrast-enhanced-MRI (DCE-MRI) and diffusion-weighted imaging (DWI) in evaluating the pathological response of muscle invasive bladder cancer (MIBC) to neoadjuvant chemotherapy (NAC), and further indirectly compare the diagnostic performance of DCE-MRI and DWI.

Methods:
Literatures associated to DCE-MRI and DWI in the evaluation of pathological response of MIBC to NAC were searched from PubMed, Cochrane Library, web of science, and EMBASE databases. The quality assessment of diagnostic accuracy studies 2 tool was used to assess the quality of studies. Pooled sensitivity (SE), specificity (SP), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the receiver operating characteristic curves (AUC) with their 95% confidence intervals (CIs) were calculated to evaluate the diagnostic performance of DCE-MRI and DWI in predicting the pathological response to NAC in patients with MIBC.

Results:
There were 11 studies involved, 6 of which only underwent DCE- MRI examination, 4 of which only underwent DWI examination, and 1 of which underwent both DCE- MRI and DWI examination. The pooled SE, SP, PLR, NLR, DOR of DCE-MRI were 0.88 (95% CI: 0.78–0.93), 0.88 (95% CI: 0.67–0.96), 7.4 (95% CI: 2.3–24.2), 0.14 (95% CI: 0.07–0.27), and 53 (95% CI: 10–288), respectively. The pooled SE, SP, PLR, NLR, DOR of DWI were 0.83 (95% CI: 0.75–0.88), 0.88 (95% CI: 0.81–0.93), 7.1 (95% CI: 4.3–11.7), 0.20 (95% CI: 0.14–0.28), and 36 (95% CI:18–73), respectively. The AUCs of SROC curve for DCE-MRI and DWI were 0.93 (95% CI: 0.91–0.95) and 0.92 (95% CI: 0.89–0.94), respectively. There were no significant differences between DWI and DCE-MRI for SE, SP, and AUC.

Conclusion:
This meta-analysis demonstrated high diagnostic performance of both DCE-MRI and DWI in predicting the pathological response to NAC in MIBC. DWI might be a potential substitute for DCE-MRI, with no significant difference in diagnostic performance between the two. However, caution should be taken when applying our results, as our results were based on indirect comparison.

Advances in knowledge:
No previous studies have comprehensively analysed the value of DCE-MRI and DWI in evaluating the pathological response to NAC in MIBC. According to the current study, both DCE-MRI and DWI yielded high diagnostic performance, with the AUCs of 0.93 and 0.92, respectively. Indirect comparison no significant difference in the diagnostic performanceof DCE-MRI and DWI.
Repeatability of quantitative individual lesion and total disease multiparametric whole-body MRI measurements in prostate cancer bone metastases
Authors: Donners Ricardo , Candito Antonio , Blackledge Matthew , Rata Mihaela , Messiou Christina , Koh Dow-Mu , Tunariu Nina 
Published: September 2023

Objectives: To assess the repeatability of quantitative multiparametric whole-body MRI (mpWB-MRI) parameters in advanced prostate cancer (APC) bone metastases. Methods: 1.5T MRI was performed twice on the same day in 10 APC patients. MpWB-MRI-included diffusion weighted imaging (DWI) and T1-weighted gradient-echo 2-point Dixon sequences. ADC and relative fat-fraction percentage (rFF%) maps were calculated, respectively. A radiologist delineated up to 10 target bone metastases per study. Means of ADC, b900 signal intensity(SI), normalised b900 SI, rFF% and maximum diameter (MD) for each target lesion and overall parameter averages across all targets per patient were recorded. The total disease volume (tDV in ml) was manually delineated on b900 images and mean global (g)ADC was derived. Bland-Altman analyses were performed with calculation of 95% repeatability coefficients (RC). Results: Seventy-three individual targets (median MD 26 mm) were included. Lesion mean ADC RC was 12.5%, mean b900 SI RC 137%, normalised mean b900 SI RC 110%, rFF% RC 3.2 and target MD RC 5.5 mm (16.3%). Patient target lesion average mean ADC RC was 6.4%, b900 SI RC 104% and normalised mean b900 SI RC 39.6%. Target average rFF% RC was 1.8, average MD RC 1.3 mm (4.8%). tDV segmentation RC was 6.4% and mean gADC RC 5.3%. Conclusions: APC bone metastases’ ADC, rFF% and maximum diameter, tDV and gADC show good repeatability. Advances in knowledge: APC bone metastases’ mean ADC and rFF% measurements of single lesions and global disease volumes are repeatable, supporting their potential role as quantitative biomarkers in metastatic bone disease.
Ultrasound-guided interventions in primary carpal tunnel syndrome: perineural injection to thread carpal tunnel release
Authors: Kumar Nishith , Chandan Shishir Kumar , Jalan Divesh , Sinha Skand , Jaiswal Binita , Singh Dharmendra Kumar 
Published: September 2023

Abstract
Carpal tunnel syndrome (CTS), the most common entrapment neuropathy, is compression of the median nerve deep to transverse carpal ligament at wrist. Ultrasonography and electrophysiological study are complementary in the diagnosis and grading of CTS in appropriate clinical settings. The initial management of patients with CTS is conservative with medical therapy and splinting. However, surgical interventions are indicated in patients in whom medical management has failed. With evolution of the concept of safe zone on ultrasonography and identification of the sonoanatomical landmarks of carpal tunnel in greater detail, Ultrasonography-guided interventions are safer and preferred over surgical management in CTS. The primary ultrasonography-guided interventions include perineural injection, perineural hydrodissection and ultrasonography-guided release of transverse carpal ligament. This review article presents the principles of ultrasonography-guided perineural injection, perineural hydrodissection in CTS, the merits and demerits of injectant used in perineural injection/ hydrodissection, and percutaneous ultrasonography-guided thread release of transverse carpal ligament utilizing the concept of safe zone of the ultrasonography-guided interventions for CTS.
Low pelvic incidence with low lordosis and distal apex of lumbar lordosis associated with higher rates of abnormal spinopelvic mobility in patients undergoing THA
Authors: Aubert Thomas , Gerard Philippe , Auberger Guillaume , Rigoulot Guillaume , Riouallon Guillaume 
Published: September 2023

AimsThe risk factors for abnormal spinopelvic mobility (SPM), defined as an anterior rotation of the spinopelvic tilt (∆SPT) ≥ 20° in a flexed-seated position, have been described. The implication of pelvic incidence (PI) is unclear, and the concept of lumbar lordosis (LL) based on anatomical limits may be erroneous. The distribution of LL, including a unusual shape in patients with a high lordosis, a low pelvic incidence, and an anteverted pelvis seems more relevant.MethodsThe clinical data of 311 consecutive patients who underwent total hip arthroplasty was retrospectively analyzed. We analyzed the different types of lumbar shapes that can present in patients to identify their potential associations with abnormal pelvic mobility, and we analyzed the potential risk factors associated with a ∆SPT ≥ 20° in the overall population.ResultsΔSPT ≥ 20° rates were 28.3%, 11.8%, and 14.3% for patients whose spine shape was low PI/low lordosis (group 1), low PI anteverted (group 2), and high PI/high lordosis (group 3), respectively (p = 0.034). There was no association between ΔSPT ≥ 20° and PI ≤ 41° (odds ratio (OR) 2.01 (95% confidence interval (CI)0.88 to 4.62), p = 0.136). In the multivariate analysis, the following independent predictors of ΔSPT ≥ 20° were identified: SPT ≤ -10° (OR 3.49 (95% CI 1.59 to 7.66), p = 0.002), IP-LL ≥ 20 (OR 4.38 (95% CI 1.16 to 16.48), p = 0.029), and group 1 (OR 2.47 (95% CI 1.19; to 5.09), p = 0.0148).ConclusionIf the PI value alone is not indicative of SPM, patients with a low PI, low lordosis and a lumbar apex at L4-L5 or below will have higher rates of abnormal SPM than patients with a low PI anteverted and high lordosis.Cite this article: Bone Jt Open 2023;4(9):668–675.
Artificial intelligence literacy for the language industry – with particular emphasis on recent large language models such as GPT-4
Authors: Krüger Ralph 
Published: September 2023

Abstract
This article explores the concept of artificial intelligence (AI) literacy in the context of the language industry, placing particular emphasis on recent large language models such as GPT-4. After a brief introduction in which the relevance of AI literacy in the language industry is highlighted, the article provides a concise overview of artificial neural networks and a brief history of neural network-based artificial intelligence. This is intended to lay the conceptual groundwork for the subsequent discussion of the basic principles and capabilities of large language models. Then, the article investigates in detail the concept of AI literacy, discussing the AI Literacy Framework proposed by Long/Magerko (2020) and illustrating the interface between AI literacy and the two adjacent digital literacies of professional machine translation literacy and data literacy. The article then zooms in on the practical applicability of AI technologies by discussing areas where workflows in the language industry (with a focus on the computer-assisted translation process) could be automated or optimised through large language models. The article concludes with some general reflections on the relevance of field-specific and societal AI literacy in the presence of powerful AI technologies.
The Process of Organizing and Developing Pesantren (Islamic Boarding Schools) Into Modern Institutions: A Multi-Cases Study in Indonesia
Authors: Jalil Abdul , Imron Ali , Arifin Imron , . Maisyaroh 
Published: September 2023

This study reviews and examines how Pesantren (Islamic Boarding Schools) exist, starting from the process of organizing, developing, what obstacles are found, up to what strategy is used by the pesantren to develop and maintain its existence. A qualitative approach was used in this study. Data collection from the multiple case studies was through observation, interview and document study. data was analyzed through a reduction process by analyzing each individual case then also analyzed across cases in a cross-case analysis. The data was also checked for validity, reliability and objectivity to ascertain the degree of credibility, dependability and conformability. The cross-case findings show that pesantren after establishment go through phases that involve the initial process of searching for identity to efforts to maintain existence through a formulated support system. Pesantrens have a unique organizational culture in various aspects and parts and are not the same as other organizational cultures. The process of organizing pesantrens indicated dynamism in the organizational process while adapting more formal administrative and procedural approaches that conform with contemporary organization management models. It was also found that the challenges of pesantren are more from internal factors especially relating to resistance to change and development emanating from the mindset of the leadership. The study reveals the spiritual framework of the founders of pesantrens in pioneering, organizing and developing their institutions. The novelty of this study lies in its comprehensive examination of pesantren starting from the process of organizing, developing and the strategies used during the development process how they exist, obstacles faced up to the strategies they use to develop and maintain their existence. The changing environment has compelled pesantren continue to improve and move minds to grow initiatives to keep up with the changes. and incorporate conventional elements into the implementation of their education system as they face a dilemma between changing or dying under pressure from the power of change itself.
Correlation between Steatosis Degree and Hypertension Degree in Non-Alcoholic Fatty Liver Disease Patients in Indonesia
Authors: Akbar Femmy Nurul , Bralianti Putri Dwi , Akbar Ridad Thaufiq , Hendarto Hari 
Published: September 2023

Non-alcoholic fatty liver disease (NAFLD) has been recognized closely linked to cardiovascular diseases including hypertension. The connection between these conditions can be attributed to lipotoxicity, that induces systemic inflammation by activating the sympathetic nervous system (SNS) and triggers the release of angiotensin II within the renin-angiotensin-aldosterone system (RAAS). This study examined the correlation between degree of steatosis and degree of hypertension in NAFLD patients at Hajj Hospital Jakarta in 2019-2022. A cross-sectional approach was used to analyse the medical record data obtained through consecutive sampling. B-mode abdominal ultrasound examination assessed the degree of steatosis in NAFLD. Blood pressure grading was based on the 2020 International Society of Hypertension (ISH) Global Hypertension Practice Guidelines. The data were processed using Somers’d test to define the correlation between steatosis and hypertension.Of 53 NAFLD subjects, 56.6% were female, and mild steatosis was dominant (54.7%). The proportion of hypertension among NAFLD patients was 39.7%, with a higher prevalence of 61.9% among those aged 50 years or older. Majority of patients were grade I hypertension, whereas all subjects with grade II hypertension exhibited severe steatosis. There was correlation between the degree of hypertension and steatosis patients with NAFLD, with a p-value of 0.029 and a weak correlation coefficient (r= 0.251). This study found a correlation between steatosis and degree of hypertension. It was suggested females aged 50 years or older with grade II hypertension should be screened for fatty liver.
Knowledge, attitude, practice about awareness of basic life support facilities for medical emergencies among dental practitioners: a cross sectional questionnaire study
Authors: Fegade Anushree Ashish , Pereira Treville , Anjali A. K. , Lalai Megha , Pereira Christina , Kallianpur Ruchika 
Published: September 2023

Background: Healthcare professionals should be trained in basic life support (BLS), as it is a basic skill which can save lives if implemented timely. An ability to react immediately to the emergency at hand and having the proper equipment and drugs needed for the emergency, can mean the difference between successful management and failure. Objective of this study is to assess the knowledge, awareness and attitude of dental practitioners towards BLS facilities.
Methods: This is a cross sectional study conducted from January to March 2021 among 250 dental interns, BDS and MDS doctors by assessing responses to 10 selected questions pertaining to BLS among dental practitioners in Mumbai/Navi Mumbai. Inclusion criteria: BDS, MDS doctors.
Results: The results of my study showed that almost (77.5%) enquire about medical history. Only (32.2%) felt competent in responding to emergency situation at clinics. (46.6%) were confident about administrating IV, I.M injections and performing cardiopulmonary resuscitation (CPR). They were also assessed for the emergency drugs and emergency kits, which were available with (49.5%).
Conclusions: The survey shows that there is substantial lack of BLS knowledge among dental practitioners. Prompt recognition & efficient management of medical emergencies can increase the likelihood of a satisfactory income. This is feasible by incorporating BLS in academic curriculum on regular basis and through hands on workshops.
Bacterial etiology, antimicrobial resistance and factors associated with community acquired pneumonia among adult hospitalized patients in Southwest Ethiopia
Authors: Mussema Abdulhakim , Beyene Getenet , Kebede Gudina Esayas , Alelign Dagninet , Mohammed Tofik , Bawore Solomon Gebre , Mohammed Seid Abdurezak , Tadesse Wondwossen , Gashaw Mulatu 
Published: September 2023

Background and Objectives: Antibiotic resistance is a significant problem that restricts the options for treating bacterial pneumonia. This research aimed to determine the bacterial causes of pneumonia and antibiotic resistance among hospitalized patients in southwest Ethiopia.
Materials and Methods: We collected and analyzed 150 sputum samples from individuals with community-acquired pneu- monia from April 1st to October 30th, 2019. Standard bacteriological procedures were used to identify the bacteria. Kirby Bauer's disk diffusion method was used to assess the bacteria's susceptibility patterns. Production of carbapenemase and extended-spectrum-lactamase were confirmed phenotypically. Odds ratios and the chi-square test were computed.
Results: On the whole, bacterial pathogens were verified in 50% of the sputum samples. The predominant bacterial isolates were Klebsiella species, followed by Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae. About 77.5% of isolates were multidrug resistant. Moreover, 40.5% and 10.8% of the isolates were ESBL and carbapene- mase producers, respectively. Aging, tobacco smoking, previous history of pneumonia, heart disease, and chronic respiratory disease had association with sputum culture-positivity.
Conclusion: As a result, it is important to regularly monitor the bacterial etiologies and their patterns of resistance. Addition- ally, sociodemographic and clinical characteristics should all be taken into account while managing patients with pneumonia empirically in this context.
Anticancer, antioxidant, and antibacterial effects of nanoemulsion of Origanum majorana essential oil
Authors: Rasti Fatemeh , Ahmadi Elahe , Safari Mojdeh , Abdollahi Abbas , Satvati Saha , Ranjbar Razie , Osanloo Mahmoud 
Published: September 2023

Background and Objectives: This study aimed to develop a natural nanoemulsion with antibacterial and anticancer prop- erties.
Materials and Methods: The chemical composition of the Origanum majorana essential oil was investigated using GC–MS analysis. Besides, the successful loading of the essential oil in the nanoemulsion was confirmed using ATR-FTIR analysis. Moreover, nanoemulsion’s anticancer, antioxidant, and antibacterial activities were investigated.
Results: Terpinen-4-o1 (46.90%) was identified as the major compound in the essential oil. The nanoemulsion with a 149 ± 5 nm droplet size and zeta potential of -11 ± 1 mV was prepared. The cytotoxic effect of the nanoemulsion against A-375 human melanoma cells (IC = 139 µg/mL) showed significantly more potency than A-549 human lung cancer cells (IC = 318 µg/mL). Interestingly, growth of Staphylococcus aureus (Gram-positive) and E. coli (Gram-negative) bacteria after treatment with 4800 µg/mL of nanoemulsion were obtained at 12 ± 2 and 6 ± 1%, respectively. However, the IC of nanoemulsion against E. coli (580 µg/mL) was not significantly different (P > 0.05) from S. aureus (611 µg/mL).

Conclusion: A straightforward preparation method, high stability, and multi-biological effects are the main advantages of the prepared nanoemulsion. Therefore it could be considered for further investigation in vivo studies or complementary medicine.
Thai University Students’ Perceptions of Factors Affecting the Thai Tourism Industry: A Case Study
Authors: Thadphoothon Janpha 
Published: September 2023

Purpose: The aim of this study was to investigate Thai university students’ perceptions of the factors that would affect the tourism industry of Thailand.
Method: Forty-five (45) undergraduates in a university in Thailand were asked to answer the questionnaire of nine questions on the effects of selected factors affecting the Thai tourism industry. The data collection was done in March 2021. The collected data were analyzed using basic descriptive statistics.
Result: The results showed that Covid-19 pandemic was perceived to be the factor with the greatest impact on Thai tourism (Mean = 4.86), followed closely by the internal political problems (Mean = 4.40). .The lowest three factors were found to be the climate crises (Mean = 3.64), US-China trade war (Mean = 3.55), and robots/AI (Mean = 3.13). Foreign language skills, communication, and technology use were among the highly cited skills and abilities Thai people should be focusing more on.
Contribution: This study adds valuable insights to the existing body of knowledge in the field of tourism and hospitality management. The findings provide a perspective on the factors influencing the industry's performance, especially revealing the intricate interplay between socio-political, environmental, and economic factors.
Detailed and Semi-detailed Geomorphological Maps: A review of relief representation in thesis by the São Paulo state’s geography postgraduate programs by the beginning of the 21st century (2001-2018)
Authors: Firmino Glauber Verner , Rodrigues Nunes João Osvaldo 
Published: September 2023

This study investigates the semi-detailed and detailed geomorphological mapping produced by researchers in the State of São Paulo in the beginning of the 21st century, considering its diversity of methods and symbology. 22 academic productions were analyzed. Criteria for selection were: year of publication, scale, possibility of downloadability, legibility and description of procedures. Scales ranged from 1:60.000 to 1:5.000. Different objectives were verified and grouped into 4 main categories: 1) Urban and/or Environmental Planning; 2) (Geo) Enviromental Zoning; 3) Environmental Vulnerability or Fragility; and 4) Geomorphological and/or Enviromental Analysis. References most cited were Tricart (1965), Verstappen & Zuidam (1975) and Ab’Saber (1969). Most research employed adaptations from two or more references. Most publications belonged to IGCE-UNESP program. We concluded that diversity of legends is mainly related to 8 factors corroborating the literature: 1) three-dimensionality of the terrain and bi-dimensionality of the map; 2) great number of the nature of represented attributes; 3) representation of both qualitative and quantitative data; 4) employment of three types of plotting information; 5) contradictions between legibility and academic interests; 6) time-space scales; 7) different types of landscapes; and 8) different objectives of research.