bluuebunny/crossref_metadata_2025_split huggingface dataset:
Professional calling among nursing students: A Latent Profile Analysis
Authors: Jiang Hu , Mei Yongxia , Wang Xiaoxuan , Zhao Zhixin , Lin Beilei , Wang Wenna , Zhang Zhenxiang 
Published: April 2023

Abstract
Background: One factor that influences nursing students' decision to pursue a nursing career is professional calling. It is important to comprehend nursing students' professional calling, which may have an impact on their career decisions and professional identities.
Objectives: To investigate possible calling types and contributing variables among nursing students.
Design: Cross-sectional descriptive study.
Participants: A total of 10583 nursing students were enrolled in this survey.
Methods: From November 16th, 2022, to January 17th, 2023, a cross-sectional study was carried out among nursing students using a convenient sampling. The subjects were given the Chinese Calling Scale and the General Demographic Information Questionnaire. Latent profile analysis (LPA) was used to separate nursing students' professional calling into a variety of subgroups. To find the variables connected to the prospective calling categories, we used ordinal and multinomial Logistic regression analysis.
Results:We divided the respondents into three calling groups, low calling group (N=3204), moderate calling group (N=4492), and high calling group (N=2887), which accounted for 30.3%, 42.4%, and 27.3% of the total respondents, respectively, in accordance with the findings of the latent profile analysis. Across scale scores and dimensions for the three separate categories, three groups demonstrated statistically significant differences (both p<0.001). Profile membership was predicted by factors such as age, gender, location of origin, first volunteer experience, highest degree earned, marital status, student leadership experience, and political appearance.
Conclusion: Three latent calling patterns were found, and there was calling variability across nursing students.Special care should be given to students with low calling. Nursing students must use professional education tools to help them develop their professional identities and stabilize the nursing team.
Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction
Authors: Zhuang Yongwen , Kim Na Yeon , Fritsche Lars G. , Mukherjee Bhramar , Lee Seunggeun 
Published: April 2023

Abstract
Background:
Genetic variants can contribute differently to trait heritability by their functional categories, and recent studies have shown that incorporating functional annotation can improve the predictive performance of polygenic risk scores (PRSs). In addition, when only a small proportion of variants are causal variants, PRS methods that employ a Bayesian framework with shrinkage can account for such sparsity. It is possible that the annotation group level effect is also sparse. However, the number of PRS methods that incorporate both annotation information and shrinkage on effect sizes is limited. We propose a PRS method, PRSbils, which utilizes the functional annotation information with a bilevel continuous shrinkage prior to accommodate the varying genetic architectures both on the variant-specific level and on the functional annotation level.
Results:
We conducted simulation studies and investigated the predictive performance in settings with different genetic architectures. Results indicated that when there was a relatively large variability of group-wise heritability contribution, the gain in prediction performance from the proposed method was on average 8.0% higher AUC compared to the benchmark method PRS-CS. The proposed method also yielded higher predictive performance compared to PRS-CS in settings with different overlapping patterns of annotation groups and obtained on average 6.4% higher AUC. We applied PRSbils to binary and quantitative traits in three real world data sources (the UK Biobank, the Michigan Genomics Initiative (MGI), and the Korean Genome and Epidemiology Study (KoGES)), and two sources of annotations: ANNOVAR, and pathway information from the Kyoto Encyclopedia of Genes and Genomes (KEGG), and demonstrated that the proposed method holds the potential for improving predictive performance by incorporating functional annotations.
Conclusions:
By utilizing a bilevel shrinkage framework, PRSbils enables the incorporation of both overlapping and non-overlapping annotations into PRS construction to improve the performance of genetic risk prediction. The software is available at https://github.com/styvon/PRSbils
Texturing the optimal wear-resistance micro/nano hierarchical structure for drug loading on titanium implants
Authors: Sefei Yang , Yanfang Zhang , Lei Zhou , Ruifang Jiang , Yuankun Hou , Tong Ding , Tengfei Wu , Chanfang Dong , Yanfei Huang , Zhiguo Xing 
Published: April 2023

Abstract
This paper aimed to texture a drug-loaded structure on the surface of the titanium implant. Firstly, ABAQUS software was used to construct the implant placement model and to calculate the imposed forces on the implant during placement. Then the femtosecond laser-machined microstructures were subjected to friction testing to select the most wear-resistant shape, and the structural parameters of the shape were optimized. A micro/nano hierarchical structure was developed on the surface of the titanium disc and commercial implant through anodization. The morphology and tribological properties were studied precisely. The results show that laser-textured dimple shapes reduced the contact area and stored wear debris, improving the wear resistance of the surface. The shape with a diameter of 150 μm, depth of 80 μm, and texture density of 5% exhibited high resistance against wear during implant insertion. In-vitro study using fresh porcine mandibles showed that TiO2 nanotubes inside the dimples remain intact after implant placement. In addition, the micro/nano hierarchical structure exhibited excellent wettability, promising for drug loading. The designed drug-loaded structure protects the original surface of the implant, which can safeguard the surface modifications of all commercial implants used clinically currently. The presented approach can improve the implant success rate in patients with bone metabolic clinical conditions.
The Effect of Social Media-Supported Learning on the Academic Achievement of Nursing Students and the Levels of Use of Social Media in Nursing Education: A Randomized Controlled Trial
Authors: Çiftçi Bahar , Erden Yasemin , Kahraman Handan Aydın 
Published: April 2023

AbstractAimThe aim of the present study was to determine the effect of social media-supported learning on the academic achievement of nursing students and the level of social media use in nursing education.Bacground:Social media in nursing education has an important place.MethodThe study had a RCT.CONSORTchecklist was used to guide the reporting of this RCT. Students were asked to fill out the necessary forms as a pre-test.The subject of parenteral drug administration was explained interactively to all students by the same instructors for a total of 12hours for3weeks.After the theoretical lesson, each skill was demonstrated by the instructor in the laboratory setting in a24-hour laboratory lesson with the demonstration method in line with the checklists.After the training was completed, the necessary forms were filled out by the students.Videos and informative images about parenteral drug applications were shared with the intervention group for 4weeks through an Instagram page that was created for social media-supported learning. Questions and answers were shared on the subject every day in the story section.The answer to the question was shared in the story section the next day with explanations.At the end of the 4th week of the training, the students were asked to fill out the necessary forms as a post-test.ResultsAfter social media-supported learning, it was found that the difference between the post-test mean scores of the nursing students in the intervention and control group was statistically significant(p < 0.001).It was also found that the average of the exam results after the training increased compared to the average of the exam results before the training and the difference between the two scores was statistically significant(p < 0.001).ConclusionIt was concluded that social media-supported education had a positive effect on the academic achievements of nursing students and the level of social media use in nursing education.Relevancetoclinical practice:The use of social media in nursing education increases the permanence of education.
Serum exosomes contain filamentous alpha-synuclein and facilitate the propagation of Parkinson’s pathology
Authors: Tsunemi Taiji , Yuta Ishiguro , Shimada Tomoyo , Yoroisaka Asako , Ueno Shin-Ichi , Takeshige-Amano Haruka , Hatano Taku , Inoue Yuichi , Saiki Shinji , Hattori Nobutaka 
Published: April 2023

Abstract
Parkinson’s disease (PD) is pathologically characterized by the deposition of a-synuclein (a-syn) containing Lewy bodies/neurites in both the central nervous system (CNS) and the peripheral nervous system (PNS). Recent evidence indicates the contribution of exosomes, nano-sized extracellular vesicles, to the dissemination of Lewy pathology in the PNS into the CNS and vice versa. We analyzed serum exosomes from patients with PD (n = 142), multiple system atrophy (MSA) (n = 18), progressive supranuclear palsy (PSP) (n = 28), rapid eye movement sleep behavior disorder (n = 31), and controls (n = 105). Although the number of exosomes significantly decreased in PD compared to controls (p = 0.002), the filamentous α-syn in exosomes quantified by our ELISA system significantly increased in PD compared to controls (p < 0.0001) and compared to MSA (p = 0.03) or PSP (p = 0.04). Further analysis revealed that exosomes facilitate the propagation of filamentous α-syn between neurons and from the PNS to the CNS. These results highlight that the serum exosomal a-syn filaments may reflect peripheral Lewy pathology and that exosomes can enhance the propagation into the CNS.
Analysis of Clinical Value and Necessity of Preoperative Colonoscopy in Patients with Anal Fistula
Authors: Xu Shumin , Zhang Luo , Cao Bo , Liu Fang , Li Zhi , Wang Kaiping 
Published: April 2023

Abstract
Background: To explore the clinical application value of preoperative colonoscopy in patients with anal fistula.
Methods: (1) This study analyzed 1796 patients with benign anorectal diseases who underwent preoperative intestinal endoscopy and met the surgical criteria in the past three years at the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine. Of these patients, 949 with anal fistula were classified as group A and 847 non-anal fistula patients were classified as group B. We compared and analyzed the general information, endoscopic findings, pathological characteristics of polyp, distribution of bowel-inflammation location, and inflammatory bowel disease examination results between the two groups of patients. (2) 2275 anal fistula patients without surgical contraindications in the past three years at the hospital were selected. Based on whether they underwent preoperative intestinal endoscopy, 949 anal fistula patients who underwent preoperative intestinal endoscopy were classified as group A and 1326 anal fistula patients who did not were classified as group C. This study compared the detection rate of endoscopic lesions and IBD results between the two groups of patients.
Results: (1) There was no statistically significant difference in general information between groups A and B, indicating comparability. However, the abnormal detection rate in group A was higher than that in group B（P＜0.01）. In terms of endoscopic findings, the detection rate of bowel inflammation, IBD, and polyps in the anal fistula group was higher than that in the non-anal fistula group（P＜0.05）. Regarding the location of inflammation, group A exhibited a higher detection rate in the terminal ileum, ileocecal region, and ascending colon than group B（P＜0.05）. The incidence of IBD in group A was higher than that in group B, but there was no statistically significant difference between the two groups（P＞0.05）. (2) The study found that there was a statistically significant difference in the intestinal endoscopic detection rate between the two anal fistula groups (groups A and C)（P＜0.01）. The detection rate of IBD in the two anal fistula groups (groups A and C) had statistical significance（P＜0.05）. The detection rate of Crohn's disease in the two anal fistula groups (groups A and C) also had statistical significance（P＜0.05）.
Conclusions: Preoperative colonoscopy is of great clinical value in the preoperative evaluation of patients with anal fistula, and it is necessary to perform preoperative colonoscopy to exclude localized perianal lesions caused by inflammatory bowel disease, thereby reducing the rate of missed diagnoses and improving treatment outcomes.
Smoothness evaluation indices during sit-to-stand-to-sit motions in healthy older females and after hip fracture using an accelerometer
Authors: Shimamura Takeshi , Ishikawa Hitoshi , Fujii Hiromi , Katoh Hiroshi 
Published: April 2023

Abstract
Background:
Studies that quantify the quality of sit-to-stand-to-sit (STS) motions, particularly in smoothness, are limited. This study aims to investigate the possibility and usefulness of qualitative evaluation during STS.
Methods:
This study included 36 females aged over 60 years, including 18 participants in each of the healthy and hip fracture groups. Measurements were performed at two different speeds: five STS as fast as possible (STSF) and 2 s for each motion (STS2s). Indices of smoothness, including the harmonic ratio (HR) and power spectrum entropy (PSE), were calculated from the measured data in each of the three axial directions and were compared.
Results:
HR in the vertical direction was significantly higher in the healthy group than in the hip fracture group for STSF and STS2s. Furthermore, PSE for all directions and triaxial composites was significantly lower for STS2s.
Conclusion:
This study suggests the usefulness of HR and PSE as qualitative evaluations for STS.
ROBO3 is a Potential Prognostic Biomarker that guides treatment option and Correlates with Immune Cell Infiltration in Acute Myeloid Leukemia
Authors: Guo Shao-Jun , Chen Xue-Xing , Jiang Qi-xia , Cui Jing-ying , Yuan Guo-Lin 
Published: April 2023

Abstract
Based on cytogenetic and genetic markers for risk stratification, patients with acute myeloid leukemia (AML) show a very heterogeneous prognosis. Overexpression of ROBO3 has been reported to confer an unfavorable outcome in AML. However, it is unclear whether the prognostic effect of ROBO3 on AML is interfered by treatment option. In this study, we analyzed 148 AML patients with ROBO3 expression information using the Cancer Genome Atlas (TCGA) database. We found ROBO3 was a new prognostic marker in AML administered chemotherapy. In multivariable analyses, high ROBO3 expression independently predicted lower EFS (HR = 1.820, P = 0.035) and OS (HR = 2.073, P = 0.011) when adjusting for other well-known prognostic factors. We further found allogeneic hematopoietic stem cell transplantation(allo-HSCT) could overcome the inferior outcomes associated with high ROBO3 expression. Construction nomograms including ROBO3 and other clinical parameters for predicting OS and EFS exhibited satisfactory accuracy and discrimination. Functional enrichment identified ROBO3 was involved in immune-related pathways. ssGSEA demonstrated notable differences and correlation in the immune cell infiltration. Notably, we confirmed that ROBO3 suppression could inhibit leukemia cell growth in vitro. Overall, our results provide new insights into the role of ROBO3 in AML, with promising clinical implications.
Sustainability Status of Karang Jeruk Reef Ecosystem Assessed by RAPFISH
Authors: Zuhry Noor , Afiati Norma , Purnomo Pujiono Wahyu , Hendrarto Boedi 
Published: April 2023

Abstract

As a coral reef in marine protected area in Tegal Regency, Central Java Province, Indonesia, Karang Jeruk has been receiving several rehabilitation efforts in the past. Yet, the result have not been comprehensive so far. It is therefore to sustain; the reef requires a planned and synergistic effort by considering several dimensions. This study aims to analyze the level of sensitivity and level of sustainability of the reef by means of RAPFISH 2013 Version R, a multidimensional scaling approach. The results showed that the highest sustainability index was the ecological dimensions (80.08), followed by technological dimensions (59.42), social dimensions (44.83), institutional dimensions (29.41) and finally the economic dimensions (25.23). Hence, constructive priorities are needed for dimensions with low sustainability index values, so that equilibrium is achieved on all dimensions.
Edaphic and topographic gradients have differential influence on woody species assemblages on serpentine and non-serpentine soils in an African Savanna
Authors: Nyenda Tatenda , Musungwa Tenderano , Piyo Tafadzwa Terrence , Kowe Pedzisai , Muvengwi Justice , Witkowski Ed F.T 
Published: April 2023

Abstract
Background and aims
Understanding the determinants of plant species associations on unique serpentine substrates is crucial for restoration ecology yet understudied. We investigated the influence of local edaphic and topographic gradients on woody species associations on serpentine and non-serpentine soils along the Zimbabwe great Dyke.
Methods
Vegetation attributes were assessed in 62 plots located on serpentine and adjacent non-serpentine patches at varying slope magnitude and orientation. Plant community comparisons and relationships with soil and topographic variables were analyzed using ANOVA and ordinations.
Results
Aspect had more influence on woody composition, species associations and densities on- compared with off-serpentine soils. Lower species richness, tree/shrub densities were observed on-serpentine than non-serpentine patches. Soil Mg, Mg/Ca ratio, total Ni, Cr and Mn, and available Ni were significantly higher on-Serpentine than off-serpentine patches. All parameters (pH, Ca, Mg, Mg/Ca ratio; available Ni, Cr, Mn and total Mn) were similar between Serpentine east- and west-facing slopes, but only total Cr and Ni were higher on east-facing slopes. Only available Ni and Mn were higher on Serpentine piedmont than on slopes. Tree/shrub density and species richness were positively correlated to available Mn and Cr while negatively correlated to total and available Ni, pH, Mg/ca ratio and herbaceous plant cover.
Conclusion
Vegetation patterns on serpentine substrates are partly driven by intra-site edaphic (metals and Ca/Mg ratios) and topographic gradients. Aspect has differential influence on woody vegetation assemblages on serpentine and non-serpentine substrates. Combinations of species and environmental determinants observed can be used in mine site rehabilitation planning.
Improving effectiveness using nimotuzumab in patients with nasopharyngeal carcinoma based on the 18F-FDG PET/CT maximum standardized uptake value
Authors: Fu Xiaobin , Li Tingting , Fei Zhaodong , Chen Chuanben 
Published: April 2023

Abstract
Background: This study was aimed towards improving the efficacy of nimotuzumab (NTZ) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC) using the maximum standardized uptake value (SUVmax) of 18F-fluorodeoxyglucose positron emission tomography (18-FDG PET) as a predictive and prognostic indicator.
Method: 248 patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) who met the inclusion criteria of our study were subjected to PET/CT scan in our hospital prior to chemoradiotherapy from January 2012 to June 2019. Survival differences and independent factors between groups were assessed by the Kaplan–Meier method, log-rank test, and Cox proportional hazards regression analysis. Outcome measures included analysis of the cost-effectiveness ratio (ICER).
Result: The optimal cutoff value for the maximum standardized uptake value (SUVmax) was 12.92 while the area under concentration-time curve (AUC) for the SUVmax was 0.596. The prognostic significance for overall survival (OS) with NTZ treatment (P=0.023) and SUVmax (P=0.014) was indicated by multivariate analysis. Exploratory subgroup survival analysis revealed that NPC patients with SUVmax >12.92 treated with concurrent chemoradiotherapy (CCRT) plus NTZ had a significantly improved 3-year OS than those treated with CCRT alone (96.2% vs. 73.2%, P=0.047). However, in those with SUVmax ≤12.92 treated with CCRT plus NTZ there was no statistically significant difference from those treated with only CCRT (97.6% vs.94.3%, P=0.129). The treatment cost with nimotuzumab was $6317.61, this additional cost being only $274.68 extra for every 1% increase in the OS rate, as indicated by the cost-effectiveness analysis.
Conclusion: In LA-NPC patients with SUVmax >12.92, adding NTZ to CCRT improves overall survival and is cost-effective. However, the addition of NTZ was not effective for patients with SUVmax ≤12.92.
Introducing MR-TADF Emitters into Light-Emitting Electrochemical Cells for Narrowband and Efficient Emission
Authors: Edman Ludvig , Tang Shi , Santos John dos , Wang Jia , Zysman-Colman Eli 
Published: April 2023

Abstract
Organic semiconductors that emit by the process of multi-resonance thermally activated delayed fluorescence (MR-TADF) can deliver narrowband and efficient electroluminescence while being processable from solvents and metal free. This renders them attractive for use as the emitter in sustainable light-emitting electrochemical cells (LECs), but so far reports on narrowband and efficient MR-TADF emission from LEC devices are absent. Here, we address this issue through careful and systematic material selection and device development. Specifically, we show that the detrimental aggregation tendency of an archetypal rigid and planar carbazole-based MR-TADF emitter can be inhibited by its dispersion into a compatible carbazole-based blend host and an ionic-liquid electrolyte; and we further demonstrate that the tuning of this active material results in the desired achievement of balanced p- and n-type electrochemical doping, high solid-state photoluminescence quantum yield of 91%, singlet and triplet trapping on the MR-TADF guest emitter, and similarly sized electron and hole transport traps. The introduction of this designed metal-free active material into an MR-TADF LEC results in the attainment of bright blue electroluminescence of 500 cd/m2, which is delivered at a high external quantum efficiency of 3.8% and a narrow full-width-at-half-maximum of 31 nm.