bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of Natural Dye Plants in Kumpang Ilong Village, Belitang Hulu District, Sekadau Regency
Authors: Listiani Etma , Masriani Masriani , Erlina Erlina 
Published: January 2025

The people of Kumpang Ilong Village, Belitang Hulu District, Sekadau Regency have used plants as natural dyes for daily needs, such as dyes for woven fabrics, food, and beverages. The use of natural dyes from local plants can be an environmentally friendly alternative compared to synthetic dyes which can cause various problems such as environmental pollution, toxicity, and the risk of allergies to humans. This study aims to identify the types, parts, and ways of using plants as natural dyes by the community of Kumpang Ilong village, Belitang Hulu District, Sekadau Regency. This study is a descriptive research to describe the use of plants used as natural dyes by the people of Kumpang Ilong Village using a data collection method that is carried out in a triangulation manner with interview, observation, and documentation techniques. The determination of 24 informants was carried out by purposive sampling technique in order to obtain detailed information. Information was obtained by direct observation using semi-structured interview techniques. The results of the study showed that there were 20 types of natural dye plants used by the people of Kumpang Ilong village, Belitang Hulu District, Sekadau Regency.
Utilization of Chili Citrus (Citrus microcarpa) as a Natural Fixator for Dyeing Cotton Fabrics with Dayak Onion Tuber Extract (Eluetherine palmifolia (L.) Merr)
Authors: Widyasari Ida Ayu Made Tania , Masriani Masriani , Hairida Hairida 
Published: January 2025

The high demand for the textile industry can pollute the environment through waste. Natural dyes from natural ingredients are used as a step to minimize this waste. Dayak onions can be used as a natural dye because they produce a red color from anthocyanin compounds. However, natural dyes have weaknesses, namely that the color is less stable and fades easily, so a fixator is needed. Fixator is used to strengthen the color in fabrics that use natural dyes. Orange chili sauce has the potential to be a natural fixator because it contains citric acid. This research aims to analyze the effect of the concentration of chili pepper fixator (Citrus microcarpa) on the color fastness of cotton fabric using natural dyes from Dayak onion bulbs (Eleutherine palmifolia (L.) Merr). The research method used was an experiment using a colorimeter application whose results were in the form of ΔE values. The test was carried out on the color of the fabric that had been dyed and fixed and then the average value (ΔE) was measured before and after washing the soap. The research results showed that the average value (ΔE) of the smallest to largest fixator was a concentration of 20%, 100%, 0%, 40%, 60% and 80%. Based on the results of the Kruskal Wallis test followed by the Bonferroni test, a significant value of 0.024 (p>0.05) was obtained at a concentration of 20%. This shows that the chili lime fixator has a significant influence on the fastness of the fabric.
Colorimetric Sensor of Hg(II) Ion from AgNPs-MO Quantified Using DIC with ED Equation Approach
Authors: Thohir Muhammad Bakhru , Tiyas Windi Pangesti Kusumaning 
Published: January 2025

Mercury is one of the heavy metals that has high toxicity, not only for the environment but also for human health. Mercury is found in many cosmetic products; unfortunately, for people who do not understand the dangers of mercury cosmetic ingredients, their skin will become red rashes. The novelty of this article is to use colorimetric sensor for mercury combined with Digital Image Colorimetry (DIC). The image is captured with the the smartphone camera and quantified using the Euclidean Distance (ED) Equation approach. In addition, the synthesized AgNPs also use the green synthesis method with natural materials as reducing agents and stabilizers. Therefore, the purpose of this study is to determine the best synthesis conditions and determine the detection performance of mercury (II) ions. The research began with the synthesis of mercury detection substances, namely silver nanoparticles reduced and stabilized by Moringa oleifera leaf extract (AgNPs-MO). In this study, it was found that silver nanoparticles began to form at 1 hour accompanied by heating at 120°C using a hotplate, while 6 hours when without heating. The optimum pH condition is 10. This mercury detection method has good sensitivity and accuracy values, with RSD values of less than 1% for each analyte in 5 repetitions.
Development of Particle Board Biocomposite From Coffee Skin and Tofu Dregs With Polyethylene Plastic Adhesive As Furniture Interior
Authors: Hidayat Ali Nurdin , Permana Edwin , Wijaya Dhian Eka , Pratama Yoga , Zufri Fauzi 
Published: January 2025

The need for particle board interiors is still in great demand to be used as wood-sourced interiors. In line with this, currently the problem of waste is still a fairly complex problem, both organic and inorganic waste. Coffee rinds and tofu pulp are organic wastes that have not been optimally utilized. Therefore, research was conducted on the manufacture of particleboard from coffee rinds and tofu pulp with PP plastic adhesive which aims to reduce the rate of deforestation due to tree felling as raw material for interior manufacturing and to control the environment by utilizing waste in the community into functional products. This study aims to determine the best formulation of particleboard made from Polyethylene plastic, coffee bean hulls and tofu pulp. Tofu dregs need to be preserved by soaking the dregs for 48 hours in a 5% glycerol solution and 15% NaCl solution in a 50:50 ratio. Then soaked for 48 hours. soaking 15.121%. To determine a good particleboard formulation, a physical evaluation of the particleboard was carried out including particleboard density test, water absorption test, moisture content test, thickness development test and instrumentation testing using SEM to see the surface structure of the particleboard. Based on the results of physical testing, the best formulation of particleboard biocomposites was obtained, namely the ratio of 70:30 (% w/b) (70% of tofu pulp and coffee bean skin and 30% of PET plastic) which is in accordance with SNI 03-2105-2006 standards. Biocomposite particleboard formulation 70:30 (% w/b) has a density of 0.60186 gr/cm3, water absorption of 95.395%, moisture content of 2.248% and an increase in thickness after soaking of 15.121%.
The persistent global disparities in environmental and climate communication scholarship
Authors: Bera Sohinee , Vilchez Amanda , Muenster Roxana M. 
Published: January 2025

IntroductionAs the climate crisis progresses, it is clear that environmental catastrophes are unequally distributed and unequally caused. The Global South is disproportionately affected by the consequences of climate change despite being less responsible for some of its anthropogenic causes, compared to the Global North.MethodsTo understand whether environmental and climate communication scholarship reflect the global nature of these crises, we conducted a publication review of 505 articles published in the top-producing journals of climate communication between 2020 and 2022, along with an authorship survey and keyword network analysis. We investigate who conducts environmental and climate communication research, the geographic focus and contextualization of the research, and the thematic focus of the research.ResultsThe Global North dominates in authorship (93%) and research focus (67%), while the Global South affiliated authors make up a fraction of the sample (7%) and of the research focus (12%), revealing a gap in scholarship based in and about the Global South. While articles across the Global North and the Global South focused on climate change and adaptation, articles about the Global South more prominently focused on disasters, vulnerability, and risk management.ConclusionThe review highlights the need for greater diversity in environmental and climate communication publishing and suggests consistent geographic naming practices in titles to achieve a more inclusive academy.
The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomization
Authors: Zhang Yongchao , Fan Wenhao , Wang Yichang , Dong Tengjing , Liu Deding , Shao Yiming 
Published: January 2025

BackgroundPrevious studies have shown that dyslipidemia is significantly associated with primary frozen shoulder and may be a risk factor for the development of primary frozen shoulder. However, these findings may be biased by a number of confounding factors. We investigated the association between serum lipids and primary frozen shoulder by retrospective analysis and two-sample Mendelian randomization (MR) methods.MethodsThis retrospective observational study included 284 patients with primary frozen shoulder diagnosed from October 2020 to October 2023 at four centers as the experimental group. Patients with diabetes and thyroid dysfunction were excluded. The control group consisted of age- and sex-matched people who underwent a health checkup. We compared total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) between the two groups. Genetic variants for the serum lipids and frozen shoulder were then extracted from large-scale genome-wide association studies. Causal effects were assessed using Inverse variance weighting (IVW), Weighted median, MR-Egger, simple and weighted models in MR analysis.ResultsThe analysis showed that after excluding patients with diabetes and thyroid dysfunction, the serum lipids (TC, TG, HDL, and LDL) in the primary frozen shoulder group were no different from those of normal individuals. None of the MR methods found significant causal evidence between them.ConclusionsDyslipidemia in patients with primary frozen shoulder may be influenced by confounding factors such as diabetes and thyroid dysfunction. These findings deepen our understanding of primary frozen shoulder risk factors.
Comparison of clinicopathological characteristics and prognosis between primary squamous cell carcinoma of the thyroid and squamous cell carcinoma combined with papillary thyroid carcinoma
Authors: Yan Wanyun , Chen Huiying , Lin Xiaoyu , Zhou Ruifa , Zhao Feng , Su Jiping 
Published: January 2025

BackgroundPrimary squamous cell carcinoma of the thyroid (PSCCT) has recently been reclassified as a morphologic pattern of anaplastic thyroid carcinoma (ATC). Consequently, PSCCT and squamous cell carcinoma with papillary thyroid carcinoma (SCC-PTC) were categorized as ATC. However, in terms of clinical characteristics and overall prognosis, whether PSCCT is similar to SCC-PTC has yet to be sufficiently investigated. Therefore, this study aimed to elucidate the differences and similarities between PSCCT and SCC-PTC regarding clinicopathological characteristics and prognosis.MethodsWe retrospectively reviewed the medical records of patients with squamous cell carcinoma of the thyroid in our institution from December 2009 to December 2020. In addition, the publications in CNKI, Wanfang, VIP, PubMed, Embase, Web of Science, and ProQuest databases were systematically searched to collect patient information. According to pathological diagnosis, patients were divided into the PSCCT and SCC-PTC groups, and compared their clinical characteristics, treatment, and prognosis, respectively.Results308 patients in the PSCCT group and 60 patients in the SCC-PTC group were enrolled in the study. There were significant differences in gender, age, T stage, N stage, M stage, symptoms at diagnosis, and TTF-1 expression between the two groups. Patients in the SCC-PTC group with more frequent radioactive iodine therapy, surgery, and less frequent radiotherapy than PSCCT. In addition, PSCCT and SCC-PTC also demonstrated similarities in tracheal invasion, esophageal invasion, CK5/6 expression, TG expression, P53 expression, and chemotherapy frequency. The 3-year overall survival rate of PSCCT (19.1%) was lower than that of SCC-PTC (34.6%). The prognostic factors were different between the two groups. Multivariable analysis shows that the N stage, M stage, radiotherapy, and tracheal invasion were related to the prognosis of PSCCT, while only the T stage was associated with the prognosis in SCC-PTC.ConclusionsClinicopathological characteristics and prognosis were not identical in patients with SCC-PTC and PSCCT. These findings indicated that different clinical treatment and management plans are required for patients with these two types of thyroid cancer.
Exploring prognosis and therapeutic strategies for HBV-HCC patients based on disulfidptosis-related genes
Authors: Zhang Chuankuo , Zhang Xing , Dai Shengjie , Yang Wenjun 
Published: January 2025

BackgroundHepatocellular carcinoma (HCC) accounts for over 80% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. Hepatitis B virus (HBV) infection is the primary etiological factor. Disulfidptosis is a newly discovered form of regulated cell death. This study aims to develop a novel HBV-HCC prognostic signature related to disulfidptosis and explore potential therapeutic approaches through risk stratification based on disulfidptosis.MethodsTranscriptomic data from HBV-HCC patients were analyzed to identify BHDRGs. A prognostic model was established and validated using machine learning, with internal datasets and external datasets for verification. We then performed immune cell infiltration analysis, tumor microenvironment (TME) analysis, and immunotherapy-related analysis based on the prognostic signature. Besides, RT-qPCR and immunohistochemistry were conducted.ResultsA prognostic model was constructed using five genes (DLAT, STC2, POF1B, S100A9, and CPS1). A corresponding prognostic nomogram was developed based on riskScores, age, stage. Stratification by median risk score revealed a significant correlation between the prognostic signature and TME, tumor immune cell infiltration, immunotherapy efficacy, and drug sensitivity. The results of the experiments indicate that DLAT expression is higher in tumor tissues compared to adjacent tissues. DLAT expression is higher in HBV-HCC tumor tissues compared to normal tissues.ConclusionThis study stratifies HBV-HCC patients into distinct subgroups based on BHDRGs, establishing a prognostic model with significant implications for prognosis assessment, TME remodeling, and personalized therapy in HBV-HCC patients.
Case report: Successful treatment with spesolimab of acrodermatitis continua of Hallopeau in an older patient without IL36RN mutations
Authors: Zheng Jianfeng , Ding Yangfeng , Shi Yuling , Yi Xuemei 
Published: January 2025

BackgroundAcrodermatitis continua of Hallopeau (ACH) is a rare, sterile pustular psoriasis variant refractory to many conventional treatments. The eruption typically occurs after local trauma or infection; other etiologies include neural, inflammatory, and genetic causes. Herein we reported a single case of a 64-year-old patient with ACH that was successfully treated with spesolimab for 19 weeks.Case summaryA 64-year-old Chinese male with no personal or known family history of psoriasis had recurrent episodes of redness, swelling, and pustules in the nail bed on seven fingers with progressive degeneration of the nails. The patient was monitored as to the evolution of the disease over half of a year before he referred his case to our attention. A diagnosis of ACH was made, allowing for the administration of local steroids and oral acitretin. However, after 3 months of acitretin treatment, no improvement was observed. In December 2023, this patient came to our inpatient department; his modified nail psoriasis severity index score was 32. Before starting treatment, a comprehensive set of laboratory and instrumental tests were all found to be negative. Moreover, whole-exome sequencing was performed in our patient, and it revealed no rare coding variant in IL36RN, CARD14, or AP1S3. Therefore, the patient was administrated with a dose of 900 mg spesolimab. After 10 days, the patient showed a significant decrease in discomfort and pain. In order to strengthen the therapeutic effect, he was given the second dose of 900 mg spesolimab after 4 weeks. After 19 weeks of spesolimab treatment, the patient’s nail lesions showed complete resolution, and no adverse effects were reported.ConclusionThe case report suggests that spesolimab may offer significant therapeutic benefits for ACH.
Characterization of NOD-like receptor-based molecular heterogeneity in glioma and its association with immune micro-environment and metabolism reprogramming
Authors: Lu Chunlin , Ma Huihao , Wang Jie , Sun Fei , Fei Mingyang , Li Ying , Liu Jing , Dong Bin 
Published: January 2025

Background and purposeThe characteristics and role of NOD-like receptor (NLR) signaling pathway in high-grade gliomas were still unclear. This study aimed to reveal the association of NLR with clinical heterogeneity of glioblastoma (GBM) patients, and to explore the role of NLR pathway hub genes in the occurrence and development of GBM.MethodsTranscriptomic data from 496 GBM patients with complete prognostic information were obtained from the TCGA, GEO, and CGGA databases. Using the NMF clustering algorithm and the expression profiles of NLR genes, these 496 GBM patients were classified into different clinical subtypes. The pathway activity of NLR and the immune micro-environment characteristics were then compared between these subtypes. A novel and accurate NLR expression profile-based prognostic marker for GBM was developed using LASSO and COX regression analysis.ResultsBased on the NLR gene expression profile, GBM patients were accurately divided into two clinical subtypes (C1 and C2) with different clinical outcomes. The two groups of patients showed different immune microenvironment characteristics and metabolic characteristics, which might be the potential reason for the difference in prognosis. Differential expression and enrichment analyzes revealed intrinsic gene signature differences between C1 and C2 subtypes. Based on the differential expression profiles of C1 and C2, prognostic molecular markers related to NLR were developed. The AUC value of the 3-year ROC curve ranged from 0.601 to 0.846, suggesting its potential clinical significance. Single-cell sequencing analysis showed that the NLR gene was mainly active in myeloid cells within GBM. The random forest algorithm identified the crucial role of TRIP6 gene in NLR pathway. Molecular biology experiments confirmed that TRIP6 was abnormally overexpressed in GBM. Knockdown of TRIP6 gene can significantly inhibit the proliferation and migration ability of GBM cells.ConclusionThe NLR signaling pathway plays a critical role in regulating immune microenvironment and metabolism reprogramming of GBM. TRIP6 is a potential hub gene within the NLR pathway and affects the malignant biological behavior of GBM cells.
Efficacy and safety of hydroxyurea therapy on patients with β-thalassemia: a systematic review and meta-analysis
Authors: Huang Tianmin , Jiang Huixian , Tang Ganling , Li Jingyi , Huang Xiaoman , Huang Zhenguang , Zhang Hongliang 
Published: January 2025

ObjectiveOur aim is to review the safety and efficacy of hydroxyurea (HU) on β-thalassemia patients.MethodsStudies that evaluated the safety and efficacy of HU on β-thalassemia patients were searched in Pub-Med, Cochrane Databases, Web of Science, China-Biology-Medicine, CNKI, Embase, VIP, and WanFang data. The proportions of response rate (RR) (50% fall in transfusion need in transfusion-dependent β-thalassemia patients, or 1 g/dL elevate in hemoglobin (Hb) levels in transfusion-independent β-thalassemia patients) and good RR (transfusion-free in transfusion-dependent β-thalassemia patients or 2 g/dL elevate in Hb levels in transfusion-independent β-thalassemia patients) were utilized to evaluate the effect size (ES). The secondary outcomes were the adverse events incidence rates of HU in β-thalassemia patients.ResultsTwo randomized controlled trials (RCTs) and 25 single-armed observational studies with typically 1,748 individuals were involved in our analysis. All 27 clinical trials were reported with fair quality. HU, in transfusion-dependent β-thalassemia patients, was related to a significant decrease in transfusion requirements [a pooled RR of 0.37 and a pooled good RR of 0.65 (95% CI, 0.53–0.76)]; in transfusion-independent β-thalassemia patients, it was correlated to an excellent raise in Hb levels [a pooled RR of 0.20 (95% CI, 0.08–0.35) and a pooled good RR of 0.53 (95% CI, 0.41–0.65)]. Neutropenia and leucopenia were the most prevalent adverse events in β-thalassemia patients treated with HU, while the incidence rates of other side effects were relatively lower.ConclusionOur findings demonstrated that β-thalassemia patients tolerated and responded well to HU. Due to the control arms absence in the involved studies, more double-masked RCTs are essential for proving the safety and efficacy of HU in β-thalassemia patients.
Association between neutrophil-to-high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2017–2020
Authors: Zhu Na , Li Yanyan , Lin Yingying , Cui XinYu , Li Xin 
Published: January 2025

BackgroundNon-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with chronic inflammation and lipid metabolism disorders. The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) is an integrative marker reflecting inflammatory responses and lipid metabolism disorders and is associated with various diseases. This cross-sectional study aimed to determine the association between NHR and NAFLD, MASLD, and liver fibrosis.MethodsData for this study were obtained from the 2017–2020 National Health and Nutrition Examination Survey (NHANES), we employed weighted multiple regression and restricted cubic spline (RCS) analysis to assess the relationship between NHR and NAFLD, MASLD, and liver fibrosis. Additionally, we performed stratified analyses based on gender, age, body mass index, diabetes, hypertension, smoking status, and history of cardiovascular disease to evaluate the consistency of these associations across different subgroups.ResultsA total of 6,526 participants were included in the study. 2,839 (weighted 44.1%) participants were diagnosed with NAFLD and 2,813 (weighted 43.7%) participants were diagnosed with MASLD. After adjusting for confounders, NHR was positively associated with the risk of NAFLD/MASLD, and the correlation was particularly significant in the subgroups of females, those without hypertension, and those without diabetes (p &lt; 0.05). By the NHR quartile, the risk of NAFLD/MASLD increased progressively with higher NHR levels (P for trend &lt;0.001). In addition, RCS analysis showed a nonlinear association between NHR and NAFLD/MASLD and liver fibrosis (P-non-linear &lt;0.05).ConclusionNHR may serve as a potential marker for NAFLD/MASLD and liver fibrosis, and lowering NHR levels could help reduce the incidence of these conditions.