bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner
Authors: Wunderlich Tim Marius , Deshpande Chandrika , Paasche Lena W. , Friedrich Tobias , Diegmüller Felix , Daus Nadine , Naseer Haniya , Stebel Sophie E. , Leers Jörg , Lan Jie , Trinh Van Tuan , Vázquez Olalla , Butter Falk , Bartkuhn Marek , Mackay Joel P. , Hake Sandra B. 
Published: August 2023

AbstractThe evolutionarily conserved histone variant H2A.Z plays a crucial role in various DNA-based processes but the underlying mechanisms by which it acts are not completely understood.Recently, we identified the zinc finger protein ZNF512B as an H2A.Z-, HMG20A- and PWWP2A-associated protein. Here, we report that ZNF512B binds the nucleosome remodeling and deacetylase (NuRD) complex. We discover a conserved amino acid sequence within ZNF512B that resembles the NuRD-interaction motif (NIM) previously identified in FOG-1 and other transcriptional regulators. By solving the crystal structure of this motif bound to the NuRD component RBBP4 and by applying several biochemical assays we demonstrate that this internal NIM is both necessary and sufficient for robust NuRD binding. Transcriptome analyses and reporter assays identify ZNF512B as a repressor of gene expression that can act in both NuRD-dependent and -independent ways. Surprisingly, high levels of ZNF512B expression lead to nuclear protein and chromatin aggregation foci that form independent of the interaction with the NuRD complex but depend on the zinc finger domains of ZNF512B. Our study has implications for diseases in which ZNF512B expression is deregulated, such as cancer and neurodegenerative diseases, and hint at the existence of more proteins as potential NuRD interactors.
Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism
Authors: Arp Nicholas L. , Seim Gretchen , Josephson Jordyn , Fan Jing 
Published: August 2023

AbstractBranched chain α-ketoacid dehydrogenase complex (BCKDC) is the rate limiting enzyme in branched chain amino acid (BCAA) catabolism, a metabolic pathway with great importance for human health. BCKDC belongs to the mitochondrial α-ketoacid dehydrogenase complex family, which also includes pyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex (OGDC). Here we revealed that BCKDC can be substantially inhibited by reactive nitrogen species (RNS) via a mechanism similar to what we recently discovered with PDHC and OGDC — modifying the lipoic arm on its E2 subunit. In addition, we showed that such reaction between RNS and the lipoic arm of the E2 subunit can further promote inhibition of the E3 subunits of α-ketoacid dehydrogenase complexes. We examined the impacts of this RNS-mediated BCKDC inhibition in muscle cells, an important site of BCAA metabolism, and demonstrated that the nitric oxide production induced by cytokine stimulation leads to a strong inhibition of BCKDC activity and BCAA oxidation in myotubes and myoblasts. More broadly, nitric oxide production reduced the level of functional lipoic arms across the multiple α-ketoacid dehydrogenases and led to intracellular accumulation of their substrates (α-ketoacids), reduction of their products (acyl-CoAs), and a lower cellular energy charge. This work revealed a new mechanism for BCKDC regulation, demonstrated its biological significance, and elucidated the mechanistic connection between RNS-driven inhibitory modifications on the E2 and E3 subunits of α-ketoacid dehydrogenases. Together with previous work, we revealed a general mechanism for RNS to inhibit all α-ketoacid dehydrogenases, which has numerous physiological implications across multiple cell types.
Are humanitarian supply chains sustainable? A systematic review and future research themes
Authors: Nawazish Mohammed , Nandakumar M.K. , Mateen Arqum 
Published: July 2023

PurposeTo address the challenges encountered in disaster responses, optimize resource utilization, minimize environmental and social impact, and ensure transparency and accountability, it is essential to review humanitarian supply chains and incorporate sustainability considerations. Humanitarian organizations can enhance their ability to deliver timely and effective assistance to those in need by continuously improving supply chain practices. Consequently, this work explores the convergence of two fast-growing domains: sustainability and humanitarian supply chain management (HSCM).Design/methodology/approachThe authors conducted a systematic literature review of peer-reviewed articles to identify the prominent research trends and themes from the two domains' interactions. The extant literature is represented under the theory, context, characteristics, and research method (TCCM) framework. The authors have utilized a stakeholder theory perspective to identify coordination and collaboration among the various stakeholders.FindingsThis study's review findings reveal five future research directions formulating this study's central themes: the role of environmental sustainability, coordination, and collaboration in building effective HSCs; the role of humanitarian aid for the responsive HSC; the influence of big data predictive analytics on the HSC performance; development and empirical validation of sustainable HSC performance framework; the role of HSC stakeholders in building effective and efficient HSCs.Originality/valueThere is no existing academic literature review available on sustainable HSCM. This review fills this void by fostering discussion about sustainable humanitarian supply chains where the authors notably propose the TCCM framework in the context of sustainable HSCM, followed by a stakeholder network.
Recognising a signature pedagogy for public relations teaching and learning in the last twenty years
Authors: Kinnear Susan Lilico , Bowman Sarah 
Published: July 2023

PurposeThis study attempts to identify the drivers for change in Public Relations education and what assumptions are made about professional practice. The authors suggest signature pedagogy has the potential to deepen our understanding of the teaching and learning of Public Relations and what this means as the Public Relations curriculum adapts. The paper has theoretical and practical value. It forefronts the concept of signature pedagogy as a fresh way to look at Public Relations teaching and learning that can be developed.Design/methodology/approachThis paper aims to explore the historical and contemporary context of teaching Public Relations within a university setting, how it has evolved and the assumptions that underpin it both nationally and internationally. Using a mixed methods approach, the paper investigates how the curriculum has changed since 2000, how it interacts with industry and how it reflects educational historical and contemporary frameworks. It also explores the assumptions on which Public Relations education was and is based and whether signature pedagogy is evidenced.FindingsThis study concludes that, from a signature pedagogy perspective, many current Public Relations curricula emphasise surface structures of learning. Deep structures, focusing on critical engagement and conceptual approaches to problem solving, are more variable, disconnected and contested. The data indicate the existence of an Anglo-American, skills-based approach to Public Relations knowledge, alongside international nuances around multi-culturalism. From a practical viewpoint, the paper contributes to how Public Relations programmes can be designed, taught and adapted in the future.Originality/valueThe paper evidences fully unique, primary research.
Football (soccer?) on campus. Examining the historical development and promotion of the world’s most popular sport through transatlantic university comparisons
Authors: Isaacson Tom , Theofilou Anastasios 
Published: July 2023

PurposeFootball is the world's most popular sport and the role of football on campus is of interest to university public relations (PR) and management professionals tasked with operations, promotions and reputation management. The purpose of the study is to explore similarities and differences in the structure and promotion of football on campus in the USA and the UK.Design/methodology/approachThe authors completed this case study research by focusing on two related cases using cross-case pattern identification. Consistent with case study research, data collection methods were combined. Depth interviews with PR and management professionals at USA and UK universities were supported by archived documents, published media and social media accounts.FindingsFootball maintains a high level of popularity among students on campus, but each country's approach reveals different models and competitive market forces. In the USA, varsity football faces competition from popular revenue-producing sports (e.g. American football and men's basketball), but growth in the overall game, which is assisted by international influences, indicates future advancement opportunities. In the UK, football is the dominant campus sport with unique ties to professional football and high growth potential for the women's game. The lack of a fan-based model indicates the possibility for structural change, but stiff competition exists with the historically popular and well-developed professional game.Research limitations/implicationsA well-known limitation of case study research is the absence of generalizability, and each case has aspects that are unique to the research (Lucas et al., 2018). That applies in this instance as well. Variance is expected to exist between, and among universities and, based on this data, this is not possible to generalize to other universities. However, future survey research could use these results to help with the development of research questions using quantitative methods.Originality/valueSports PR research using the case model with professional teams has been conducted, but the authors found no published PR research comparing the structure and promotion of football at USA and UK universities. The outcomes can help with future research inquiries and theory development and are instructive for professionals working in the field.
Managing the high capital cost of prefabricated construction through stakeholder collaboration: a two-mode network analysis
Authors: Zhang Youxi , Liu Yu , Yu Rui , Zuo Jian , Dong Na 
Published: July 2023

PurposePrefabricated construction (PC) can benefit construction industry due to its high efficiency, energy saving, consumption reduction and safety. However, the high capital cost is a critical challenge hindering its development in China. The collaboration of PC stakeholders is conducive to improving cost management efficiency and optimizing resource allocation which has been ignored in previous studies. Therefore, this study aims to explore the collaboration paths of stakeholders in the process of solving critical cost influencing factors (CIFs) of PC to reduce costs.Design/methodology/approachFirstly, 25 CIFs and five main stakeholders that affect PC capital cost were identified through literature research and expert interviews. Then, questionnaires were used to investigate the relationship between stakeholders and CIFs from the perspectives of three stakeholder attributes of proximity, attitude and power, respectively. Finally, based on the survey data, three stakeholder-CIF networks from three attributes perspective and a comprehensive network were constructed and used for subsequent social network analysis.Findings(1) Stakeholders mainly show willingness and potential to collaborate on organization and management factors; (2) More stakeholders pay attention to incentive policies and the setting of prefabrication rates and assembly rates, while all stakeholders have the right to facilitate information and resource sharing in the PC supply chain; (3) The comprehensive network shows a core-periphery structure. As core stakeholders, contractor, designer and manufacturer are more likely to actively manage the 14 core CIFs.Originality/valueThis paper innovatively combined stakeholder and cost management in PC, and used two-mode network based on three stakeholder perspectives to reveal the collaboration potential and motivation of stakeholders in PC cost management. The findings not only provide guidance for stakeholders to find potential partners and optimize resource allocation in solving specific cost issues, but also facilitate stakeholders' sustainable collaboration to achieve PC's cost performance.
Decoding the data economy: a literature review of its impact on business, society and digital transformation
Authors: Sestino Andrea , Kahlawi Adham , De Mauro Andrea 
Published: August 2023

PurposeThe data economy, emerging from the current hyper-technological landscape, is a global digital ecosystem where data is gathered, organized and exchanged to create economic value. This paper aims to shed light on the interplay of the different topics involved in the data economy, as found in the literature. The study research provides a comprehensive understanding of the opportunities, challenges and implications of the data economy for businesses, governments, individuals and society at large, while investigating its impact on business value creation, knowledge and digital business transformation.Design/methodology/approachThe authors conducted a literature review that generated a conceptual map of the data economy by analyzing a corpus of research papers through a combination of machine learning algorithms, text mining techniques and a qualitative research approach.FindingsThe study findings revealed eight topics that collectively represent the essential features of data economy in the current literature, namely (1) Data Security, (2) Technology Enablers, (3) Business Implications, (4) Social Implications, (5) Political Framework, (6) Legal Enablers, (7) Privacy Concerns and (8) Data Marketplace. The study resulting model may help researchers and practitioners to develop the concept of data economy in a structured way and provide a subset of specific areas that require further research exploration.Practical implicationsPractically, this paper offers managers and marketers valuable insights to comprehend how to manage the opportunities deriving from a constantly changing competitive arena whose value is today also generated by the data economy.Social implicationsSocially, the authors also reveal insights explaining how the data economy features may be exploited to build a better society.Originality/valueThis is the first paper exploring the data economy opportunity for business value creation from a critical perspective.
Does marketing orientation impact the innovation activity of R&D departments influenced by user-driven innovation? The correspondence analysis
Authors: Szopik-Depczyńska Katarzyna , Dembińska Izabela , Barczak Agnieszka , Szczepaniak Krzysztof , Secka Jim , Ioppolo Giuseppe 
Published: August 2023

PurposeThere are many studies explaining the innovation activity determinants. Nowadays, the digitalization of sales, the influence of social media, user-driven innovation (UDI) activity might be considered as one of the crucial sources for the development of new products within the research and development activity. Undertaken research is therefore aimed at determining whether the marketing orientation, i.e. the purchasing behavior of customers, affects the innovation activity of R&D departments that work under the usage of UDI concept.Design/methodology/approach57 R&D departments operating in Poland participated in the study. Correspondence analysis based on the Burt matrix and Cramer's V correlation coefficients was used for the analysis.FindingsThe analysis shows that R&D departments in Poland using marketing research and examining consumer purchasing behavior, positively assess the effects of using the UDI concept in R&D departments. They implement it to create or improve products or services offered on the market, especially in the field of customization, while using information from national research and development units in Poland. The motivation for these activities is mainly to increase the assortment level.Research limitations/implicationsThe conducted study covers only R&D departments in Poland, thus it is worth extending the generalization of the results. In terms of future research directions, it's worth to analyze the data from R&D departments in other countries. The results of such studies could be used for comparative analyses. The main limitation of the research is that the research sample was 57 R&D departments of enterprises operating in Poland. Therefore, the research results can't be generalized to all the R&D departments in Poland.Practical implicationsThe findings could help researchers and practitioners improve their understanding of the determinants of innovation activity, especially its relationship to marketing orientation and UDI practices.Originality/valueThe research regarding marketing orientation of enterprises and its influence on innovation activity is extremely important due to the general change of the conditions for the functioning of enterprises and building their competitive advantage. Knowledge in this area is still insufficient and research gaps are still being exposed. The article presents the correlation between the marketing orientation and customer behavior within the UDI activity and effects of innovation activity of R&D departments being under investigation.
Is sustained participation a myth in crowdsourcing? A review
Authors: Humayun Hasan , Ghazali Masitah , Malik Mohammad Noman 
Published: August 2023

PurposeThe motivation to participate in crowdsourcing (CS) platforms is an emerging challenge. Although researchers and practitioners have focused on crowd motivation in the past, the results obtained through such practices have not been satisfactory. Researchers have left unexplored research areas related to CS pillars, such as the evolution of the crowd’s primary motivations, seekers applying effective policies and incentives, platform design challenges and addressing task complexity using the synchronicity of the crowd. Researchers are now more inclined to address these issues by focusing on sustaining the crowd’s motivation; however, sustaining the crowd’s motivation has many challenges.Design/methodology/approachTo fill this gap, this study conducted a systematic literature review (SLR) to investigate and map the challenges and factors affecting sustained motivation during CS with the overcoming implications. Studies that satisfied the inclusion criteria were published between 2010 and 2021.FindingsImportant sustainable factors are extracted using the grounded theory that has sustained participation and the factors' cohesion leads to the identification of challenges that the pillars of CS face. Crowds being the most vital part of CS contests face the challenge of engagement. The results reported the factors that affect the crowd’s primary and post-intentions, perceived value of incentives and social and communal interaction. Seekers face the challenge of knowledge and understanding; the results identify the reason behind the crowd’s demotivation and the impact of theories and factors on the crowd's psychological needs which helped in sustaining participation. Similarly, the platforms face the challenge of being successful and demanding, the results identify the latest technologies, designs and features that seekers proclaim and need the platforms designer's attention. The identified task challenges are completion and achievement; the authors have identified the impact of trait of task and solving mechanisms that have sustained participation.Originality/valueThe study identifies, explores and summarizes the challenges on CS pillars researchers are facing now to sustain contributions by keeping participants motivated during online campaigns. Similarly, the study highlights the implication to overcome the challenges by identifying and prioritizing the areas concerning sustainability through the adoption of innovative methods or policies that can guarantee sustained participation.
Open innovation strategy: a systematic literature review
Authors: Sá Tiago , Ferreira João J.M. , Jayantilal Shital 
Published: July 2023

PurposeIn a context each day more global, a new paradigm has emerged – open innovation (OI) – which may be understood as an innovation strategy in which organizations use internal and external knowledge to leverage their business value, thus maintaining a sustainable competitive advantage. This article aims to contribute to understanding this phenomenon, suggesting an integrated vision of OI strategies.Design/methodology/approachThis paper systematically reviews and analyzes a sample of 66 articles from Scopus and Web of Science databases related to open innovation strategies.FindingsThe results obtained enabled us to group the existing literature into six different clusters: (1) Performance; (2) Open business model; (3) Intellectual Property; (4) Knowledge Management; (5) Innovation; and (6) Culture. Furthermore, this study identifies the major research gaps and provides suggestions for future research.Originality/valueThe paper presents the main elements that interfere and interact in the innovation strategy providing a conceptual model that can be useful in understanding the phenomenon of open innovation.
Investigating stakeholder perceptions of graduate employability
Authors: Gupta Pragya , Mahajan Renuka 
Published: August 2023

PurposeThe study aims to ratify skills necessary to bridge the gap between the existing models and emerging needs of a technology-enabled workspace; especially in the Indian context.Design/methodology/approachThis paper extends the ongoing debate on a relevant employability framework suitable both for higher education institutes and corporates. To remain resilient to future catastrophes similar to the ongoing pandemic, the relevancy of established employability skills to suit the changing scenario needs to be established.FindingsThe partial least squares (PLS) technique has been used to present a framework confirming the importance of digital competencies, business fundamentals and behavioral skills. In-depth discussions with specialists ratified the proposed framework and recommended potential changes in curriculum and pedagogy.Research limitations/implicationsThis study validates an explicit and comprehensive employability skill framework and useful recommendations in teaching strategies, which may provide a broad skill base for graduates to prepare for the volatile business environment in the long run.Practical implicationsThe study has been able to put forth significant employability skills as deemed significant by the three stakeholders. This will provide guidance to higher educational institutions (HEIs) to come up with a broad skill-base for the fresh graduates and prepare them for the volatile business environment and encourage life-long learning to remain productive in the long run.Originality/valueThe study is unique as it incorporates the perceived importance of the competencies assumed by each stakeholder, namely, employers, faculty and management graduates, which was unfortunately lacking in earlier researches.