bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prognostic score from a multicentric retrospective analysis of patients affected by sarcoma with metachronous lung metastases undergoing metastasectomy
Authors: Gallina Filippo Tommaso , Melis Enrico , Bertolaccini Luca , Spaggiari Lorenzo , Rocca Michele , Donati Davide Maria , Chiappetta Marco , Margaritora Stefano , Bertoglio Pietro , Solli Piergiorgio , Mammana Marco , Rea Federico , Onesti Elisa Concetta , Ferraresi Virginia , Sperduti Isabella , Ciliberto Gennaro , Facciolo Francesco 
Published: February 2023

AbstractBackgroundDespite the lack of evidence‐based on prospective randomized studies, surgery has become the cornerstone of the treatment in patients with pulmonary oligometastatic sarcomas. Our study aimed to construct a composite prognostic score for metachronous oligometastatic sarcoma patients.MethodsA retrospective analysis was performed on data patients who underwent radical surgery for metachronous metastases in six research institutes from January 2010 to December 2018. The log‐hazard ratio (HR) obtained from the Cox model was used to derive weighting factors for a continuous prognostic index designed to identify differential outcome risks.ResultsA total of 251 patients were enrolled in the study. In the multivariate analysis, a longer disease‐free interval (DFI) and a lower neutrophil‐to‐lymphocytes ratio (NLR) were predictive of a better overall survival (OS) and disease‐free survival (DFS). A prognostic score was developed based on DFI and NLR data, identifying 2 risk class groups for DFS (3‐years DFS 20.2% for the high‐risk group [HRG]and 46.4% for the low‐risk group [LRG] [<0.0001]) and 3 risk groups for OS (3 years OS 53.9% for the HRG vs. 76.9% for the intermediate‐risk group and 100% of the LRG (p < 0.0001)).ConclusionThe proposed prognostic score effectively predicts outcomes for patients with lung metachronous oligo‐metastases from the surgically treated sarcoma.
Comprehensive physiological, transcriptomic, and metabolomic analysis of the response of Panicum miliaceum L. roots to alkaline stress
Authors: Ma Qian , Wang Honglu , Wu Enguo , Yuan Yuhao , Feng Yu , Zhao Lin , Feng Baili 
Published: February 2023

AbstractAlkaline stress disrupts transcriptional expression and causes metabolite accumulation, thus affecting plant growth. However, there are gaps in the response mechanism of plants to alkaline stress at the molecular dimension. Broomcorn millet (Panicum miliaceum L.) is a pioneer plant for stress resistance also is a future smart food crop. To explore the physiological‐molecular response and adaptation mechanism of broomcorn millet root to alkaline stress, we conducted physiological, transcriptomic, and metabolomic analyses on roots of two broomcorn millet cultivars (alkaline‐sensitive S223 and alkaline‐tolerant T289) that were exposed to normal conditions (CK) and alkaline stress (AS) treatments (40 mM and a molar ratio of Na2CO3: NaHCO3 = 1:9) for 7 days. Alkaline stress inhibited mineral uptake in broomcorn millet roots and enhanced the antioxidant enzyme activities, malondialdehyde, and soluble substances, resulting in changes in growth, biomass, and root structure. Correspondingly, differentially expressed genes induced by alkaline stress were prominently enriched in the plant hormone signal transduction, mitogen‐activated protein kinase (MAPK) signaling, phenylpropanoid biosynthesis, ATP binding cassette (ABC) transporters, and other biological pathways. Similar results were obtained from the differentially accumulated metabolites analysis. In addition, joint transcriptome and metabolome analysis indicated that genes of phenylpropanoid and flavonoid biosynthesis pathways were upregulated or downregulated in AS groups, however, the related metabolite accumulations were inhibited. This study integrates multiple methods to uncover the mechanisms of broomcorn millet response to alkaline stress. These findings suggest a new direction for phytoremediation of alkaline lands.
Effects of straw mixed mulch length and coverage on infiltration, soil and water loss of Loess Plateau slopes
Authors: Wang Chenguang , Zhang Xiumei , Wang Yangxiu , Ma Bo 
Published: February 2023

AbstractTo study the influence of the wheat straw length and mulching on soil erosion under mixed mulch application, indoor simulation experiments were adopted to study the characteristics of infiltration, runoff and sediment yield changes under a rainfall intensity of 90 mm hr−1. The results indicated that the length, coverage and interaction imposed significant effects on these variables. With increasing coverage, the infiltration exhibits a trend of first increasing and then decreasing. The change trend of runoff and sediment is the opposite of the infiltration trend. When the length is less than or equal to 8–10 cm and the coverage is lower than 4.5 t hm−2, the sum of the length and coverage multiplied by the length and coverage attains a power function relationship with the slope infiltration rate. When the length is greater than or equal to 8–10 cm and the coverage is lower than 4.5 t hm−2, the sum of the length and coverage multiplied by the coverage divided by the length attains a power function relationship with slope infiltration rate. The reciprocal of these two variables attains a power function relationship with runoff and sediment yield. In this study, when the length ranged from 8–10 cm and the coverage was 3.5 t hm−2, the average infiltration rate was the highest, and the cumulative runoff and sediment yield were the lowest. Mixed straw mulching can effectively increase infiltration and reduce runoff and sediment yield, which is of great significance for the sustainable development of agriculture and ecology on slope farms.
Stable Organic Antimony Halides with Near‐Unity Photoluminescence Quantum Yield for X‐Ray Imaging
Authors: Meng Haixing , Chen Bing , Zhu Wenjuan , Zhou Zijian , Jiang Tianxiang , Xu Xiuwen , Liu Shujuan , Zhao Qiang 
Published: February 2023

AbstractX‐ray imaging technology has been widely used in the fields of environmental monitoring, safety inspection, nondestructive examination, space exploration, and medical diagnosis, among which scintillation materials play a vital role in indirectly converting X‐ray to visible photons. Here, a zero‐dimensional organic–inorganic hybrid halide C50H44P2SbCl5 crystal is prepared via a facile antisolvent precipitation method at room temperature. The single crystal of C50H44P2SbCl5 displays a strong yellow broadband emission centered at 592 nm with a near‐unity photoluminescence quantum yield of 98.42%. Importantly, C50H44P2SbCl5 crystals show great environmental stability and irradiation stability. Radioluminescence characterization indicates that C50H44P2SbCl5 crystals exhibit a good linear response to X‐ray dose rates along with an excellent light yield of 44 460 photons MeV−1, surpassing that of commercial inorganic LuAG:Ce scintillator. The spatial resolution of the C50H44P2SbCl5‐based scintillating screen is determined to be 8.2 lp mm−1. In conjunction with polymer thin film, the excellent scintillating feature of organic–inorganic hybrid halides offers exciting opportunities for achieving high‐quality flexible X‐ray imaging.
Navigator‐based slice tracking for kidney pCASL using spin‐echo EPI acquisition
Authors: Zhang Ke , Triphan Simon M. F. , Ziener Christian H. , Jende Johann M. E. , Kauczor Hans‐Ulrich , Schlemmer Heinz‐Peter , Sedlaczek Oliver , Kurz Felix T. 
Published: February 2023

PurposeTo apply a navigator‐based slice‐tracking method to prospectively compensate respiratory motion for kidney pseudo‐continuous arterial spin labeling (pCASL), using spin‐echo (SE) EPI acquisition.MethodsA single gradient‐echo slice selection and projection readout at the location of the diaphragm along the inferior–superior direction was applied as a navigator. Navigator acquisition and fat suppression were inserted before each transverse imaging slice of the readouts of a 2D‐SE‐EPI‐based pCASL sequence. Motion information was calculated after exclusion of the signal saturation in the navigator signal caused by EPI excitations. The motion information was then used to directly adjust the slice positioning in real time.ResultsThe respiratory motion from the navigator signal was calculated, and slice positioning was changed in real time based on the motion information. We could show that motion compensation reduces kidney movement, and that the coefficients of variation across renal perfusion values were significantly reduced when motion correction was applied. The average reduction of coefficients of variation was approximately 20%, resulting in a more accurate and detailed structure of the respective perfusion maps.ConclusionsThis study demonstrates the feasibility of a navigator‐based slice‐tracking technique in kidney imaging with a SE‐EPI readout pCASL sequence to reduce kidney motion.
Influence of interface transition zone on effective elastic property of heterogeneous materials with an artificial neural network study
Authors: Xue Jing , Cao Yajun , Burlion Nicolas , Shao Jianfu 
Published: February 2023

AbstractIn this study, the influence of interface transition zone (ITZ) on the elastic properties of concrete and rock like heterogeneous materials is investigated. Direct simulations of a representative volume element are realized by using a fast Fourier transform based method and the obtained results are used as the reference solutions. Some widely used analytical homogenization models are evaluated by comparing the theoretical predictions with the reference solutions. Based on this evaluation, an artificial neural network (ANN) model is constructed in order to improve the analytical models. The proposed ANN model is trained, tested and validated against the reference solution. Its efficiency and good accuracy are clearly demonstrated.
Intention to leave the profession and related factors in nurses: A cross‐sectional study in Kermanshah, Iran
Authors: Maleki Raheleh , janatolmakan Maryam , Fallahi Masoud , Andayeshgar Bahare , Khatony Alireza 
Published: February 2023

AbstractAimTo investigate the intention to leave the profession and its related factors among nurses in Kermanshah, western Iran.DesignCross‐sectional study.MethodsA total of 377 nurses were enrolled in a stratified random sampling method. Data were collected by the Anticipated Turnover Scale and a sociodemographic information form. and analysed by descriptive and inferential statistics (logistic regression analysis).ResultsThe results showed that 49.6% (n = 187) of nurses tended to leave the profession and the mean score of intention to leave was 36.6 ± 0.5 of 60. There were no statistically significant differences between nurses who intended to leave and those who did not in terms of age, marital status, gender, type of employment, type of shift and work experience. But a statistically significant association was found between workplace (p = 0.041, adjusted OR = 2.07) and job title (p = 0.016, adjusted OR = 0.58) and intention to leave the profession.Patient or Public ContributionNo
Conformal structure‐preserving method for two‐dimensional damped nonlinear fractional Schrödinger equation
Authors: Wu Longbin , Ma Qiang , Ding Xiaohua 
Published: February 2023

AbstractThis paper mainly analyzes conservation laws and convergence of splitting conformal multisymplectic scheme for solving the two‐dimensional damped nonlinear fractional Schrödinger equation. In order to obtain conformal multisymplectic scheme, first using Strang splitting method, the original problem is split into conservative multisymplectic and dissipative multisymplectic systems. The conservative multisymplectic system is numerically solved and the dissipative part is solved exactly. And then there shows the corresponding conservation laws and numerical scheme, in which the implicit midpoint method is used in time and the Fourier pseudospectral method is used in space, it also preserves conformal multisymplectic, the global conformal symplectic and global conformal mass conservation laws. Most important of all, we discuss convergence of the proposed scheme which is second‐order accuracy in time and spectral accuracy in space. Finally, the validity and accuracy of the theoretical results are verified by several numerical examples.
Uncoordinated federalism: Subnational response to the pandemic crisis in Mexico
Authors: Cejudo Guillermo M. , Gómez‐Álvarez David 
Published: February 2023

AbstractThe COVID‐19 pandemic has demanded prompt actions from governments all over the world. In both developed and developing countries, national governments have had to make unprecedented decisions to face the extraordinary challenges posed by the pandemic. In this paper, we explore how, due to the limited intervention from the Mexican federal government (in terms of policy actions, funding mechanisms and acting as a coordinating agent), state governments stepped up to respond to the pandemic. We argue that Mexico's response was relatively decentralized and substantially shaped by individual subnational governments. Based on a new dataset of over 600 subnational governments' responses to the social and economic effects of the pandemic, we show that state governments decided to react to the pandemic with their own policy measures, responding locally to pressing concerns. Furthermore, we demonstrate that state government responses varied widely in their scope and ambition, which exacerbated the pandemic's uneven national effects. We further contend that the structural constraints of Mexico's federalism have had an impact on these reactions, as social policy responsibilities at the state and local levels have historically been opaque and fragmented and state governments lack the funding necessary to implement sufficient and innovative initiatives.
Registration of ‘S17‐2243C’: A non‐genetically modified maturity group IV soybean cultivar with high yield and elevated oil concentration
Authors: Chen Pengyin , Shannon J. Grover , Lee Dongho , do Granja Matheus Ogando , Vieira Caio Canella , Lee Yi‐Chen , Ali Md Liakat , do Nascimento Emanuel Ferrari , Scaboo Andrew , Crisel Melissa , Smothers Scotty , Clubb Michael , Selves Stewart , Nguyen Henry T. , Li Zenglu , Mitchum Melissa Goellner , Averitt Ben , Bond Jason P. , Meinhardt Clinton G. , Usovsky Mariola , Li Shuxian , Smith James R. , Gillen Anne M. , Mengistu Alemu , Zhang Bo , Mozzoni Leandro Angel , Moseley David 
Published: February 2023

Abstract‘S17‐2243C’ (Reg. no. CV‐557, PI 700003) is a semi‐determinate, maturity group IV (relative maturity 4.9), non‐genetically modified (non‐GM) soybean [Glycine max (L.) Merr.] cultivar developed and released by the University of Missouri‐Fisher Delta Research, Extension, and Education Center. S17‐2243C was developed to meet the growing demands for new non‐GM soybean cultivars with high yield and elevated seed oil content. S17‐2243C is resistant to stem canker and charcoal rot and has tolerance to salinity conditions. Seed of S17‐2243C has averaged 232 g kg−1 of oil concentration on a dry weight basis, which was significantly higher than all check cultivars in the 2020 USDA Uniform Soybean Tests, Southern States. S17‐2243C was tested against high‐yielding private and public soybean cultivars from 2018 to 2021 in 80 locations across 12 states, including Alabama, Arkansas, Illinois, Kentucky, Louisiana, Mississippi, Missouri, North Carolina, Ohio, South Carolina, Tennessee, and Virginia. With high yield potential, broad adaptability, early maturity, elevated seed oil content, and non‐GM traits, S17‐2243C is an excellent cultivar choice for soybean growers adopting alternative growing systems and benefiting from premium prices offered for non‐GM soybean products.
Ultra‐high‐field pharmacological functional MRI of dopamine D1 receptor‐related interventions in anesthetized rats
Authors: Kimura Yuka , Nakazawa Shunsuke , Nishigori Kantaro , Mori Yuki , Ichihara Junji , Yoshioka Yoshichika 
Published: February 2023

AbstractThe dopamine D1 receptor (D1R) is associated with schizophrenia, Parkinson's disease, and attention deficit hyperactivity disorder. Although the receptor is considered a therapeutic target for these diseases, its neurophysiological function has not been fully elucidated. Pharmacological functional MRI (phfMRI) has been used to evaluate regional brain hemodynamic changes induced by neurovascular coupling resulting from pharmacological interventions, thus phfMRI studies can be used to help understand the neurophysiological function of specific receptors. Herein, the blood oxygenation level‐dependent (BOLD) signal changes associated with D1R action in anesthetized rats was investigated by using a preclinical ultra‐high‐field 11.7‐T MRI scanner. PhfMRI was performed before and after administration of the D1‐like receptor agonist (SKF82958), antagonist (SCH39166), or physiological saline subcutaneously. Compared to saline, the D1‐agonist induced a BOLD signal increase in the striatum, thalamus, prefrontal cortex, and cerebellum. At the same time, the D1‐antagonist reduced the BOLD signal in the striatum, thalamus, and cerebellum by evaluating temporal profiles. PhfMRI detected D1R‐related BOLD signal changes in the brain regions associated with high expression of D1R. We also measured the early expression of c‐fos at the mRNA level to evaluate the effects of SKF82958 and isoflurane anesthesia on neuronal activity. Regardless of the presence of isoflurane anesthesia, c‐fos expression level was increased in the region where positive BOLD responses were observed with administration of SKF82958. These findings demonstrated that phfMRI could be used to identify the effects of direct D1 blockade on physiological brain functions and also for neurophysiological assessment of dopamine receptor functions in living animals.
Structural design and performance study of corrugated fibreboard with a laminated structure
Authors: Li‐na Zhou , Chen Zhong , Li Liu , Yan‐ping Guo , Xin Chen , Zheng Xia 
Published: February 2023

AbstractCorrugated box is an important transport packaging container in the global logistics. The research on its raw material, that is, corrugated fibreboard, has always been an important topic in the packaging field. However, the research objects nearly focus on the corrugated fibreboard of traditional corrugated medium. The innovative research on the structure of corrugated fibreboard is also still rare. Since the pandemic COVID‐19 in 2020, the international corrugated packaging industry has faced new dilemma. The development of new corrugated boxes and fibreboard is the way to break the situation in innovation and transformation. This study aims to design a new fibreboard with laminated structure medium for obtaining a new type of corrugated fibreboard for packaging with better cushioning and anti‐vibration performance than traditional corrugated fibreboard. The verification experiments show that the new fibreboard has better recovery and structural stability due to its unique three‐layer structure. The static and dynamic cushioning performance and anti‐vibration performance of the proposed fibreboard have been greatly improved compared with those of the traditional one.
Twin‐analysis verification: A new verification approach to alleviate pitfalls of own‐analysis verification
Authors: Hotta Daisuke , Kadowaki Takashi , Yonehara Hitoshi , Ishibashi Toshiyuki 
Published: February 2023

AbstractIn operational numerical weather prediction (NWP), forecast verification against analysis from the same experiment is part of the standard evaluation practice. This “own‐analysis” verification is beneficial in providing complete and uniform spatial coverage but is known to suffer from overestimated skill scores when applied to short‐range forecasts due to the inevitable positive correlation between the forecast and analysis errors. To alleviate this problem, a new approach termed “twin‐analysis” verification is proposed. In this approach, the forecasts are verified against “twin analyses” that are produced by running an independent cycle using the same NWP system as the one used to produce the forecasts, but initializing the cycle using an independent first guess at the very beginning. In this way the error correlation between the forecasts and analyses is reduced, if not completely removed, while preserving the statistical properties of the analyses, allowing for a clearer interpretation of verification. This note reports the results of comparison between “twin‐analysis” and “own‐analysis” verification scores obtained for the Japan Meteorological Agency's global NWP system. It is reported that the two scores disagree up to 48 hr or even longer depending on the regions and elements, which highlights the reliability limit of “own‐analysis” verification. The proposed method does not completely remove the error correlation issue and also requires high computational costs; a practical use of the proposed approach in an operational environment is also discussed.
Different reactivities of H3O+(H2O)n with unsaturated and saturated aldehydes: ligand‐switching reactions govern the quantitative analytical sensitivity of SESI‐MS
Authors: Španěl Patrik , Dryahina Kseniya , Omezzine Gnioua Maroua , Smith David 
Published: February 2023

RationaleThe detection sensitivity of secondary electrospray ionisation mass spectrometry (SESI‐MS) is much lower for saturated aldehydes than for unsaturated aldehydes. This needs to be understood in terms of gas phase ion‐molecule reaction kinetics and energetics to make SESI‐MS analytically more quantitative.MethodsParallel SESI‐MS and selected ion flow tube mass spectrometry (SIFT‐MS) analyses were carried out of air containing variable accurately determined concentrations of saturated (C5, pentanal; C7, heptanal; C8 octanal) and unsaturated (C5, 2‐pentenal; C7, 2‐heptenal; C8, 2‐octenal) aldehyde vapours. The influence of the source gas humidity and the ion transfer capillary temperature, 250 and 300°C, in a commercial SESI‐MS instrument was explored. Separate experiments were carried out using SIFT to determine the rate coefficients, k73, for the ligand‐switching reactions of the H3O+(H2O)3 ions with the six aldehydes.ResultsThe relative slopes of the plots of SESI‐MS ion signal against SIFT‐MS concentration were interpreted as the relative SESI‐MS sensitivities for these six compounds. The sensitivities for the unsaturated aldehydes were 20 to 60 times greater than for the corresponding C5, C7 and C8 saturated aldehydes. Additionally, the SIFT experiments revealed that the measured k73 are three or four times greater for the unsaturated than for the saturated aldehydes.ConclusionsThe trends in SESI‐MS sensitivities are rationally explained by differences in the rates of the ligand‐switching reactions, which are justified by theoretically calculated equilibrium rate constants derived from thermochemical density functional theory (DFT) calculations of Gibb's free energy changes. The humidity of SESI gas thus favours the reverse reactions of the saturated aldehyde analyte ions, effectively suppressing their signals in contrast to their unsaturated counterparts.