bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico Validation of Pseudomonas aeruginosa Exotoxin A Domain I
Interaction with the Novel Human scFv Antibody
Authors: Shadman Zahra , Ghasemali Samaneh , Farajnia Safar , Mortazavi Mojtaba , Biabangard Atefeh , Khalili Saeed , Rahbarnia Leila 
Published: March 2023

Background::
Pseudomonas (P.) aeruginosa is one of the leading causes of nosocomial
infections. The pathogenicity of P. aeruginosa is related to its inherent antimicrobial resistance and the
diverse virulence factors of this bacterium. Owing to the specific role of exotoxin A in P. aeruginosa
pathogenesis, it is known as a promising therapeutic candidate to develop antibodies as an alternative
to antibiotics.

Objective::
The present study aimed to validate the interaction between a single-chain fragment variable
(scFv) antibody identified from an scFv phage library against domain I exotoxin A by bioinformatic
tools.

Method::
For this, several bioinformatics tools, including Ligplot, Swiss PDB viewer (SPDBV),
PyMOL, I-TASSER, Gromacs, and ClusPro servers were used to evaluate the interaction of scFv antibody
with P. aeruginosa exotoxin A. The I-TASSER server was utilized to predict the function and
structure of proteins. The interaction of two proteins was analyzed using ClusPro tools. The best docking
results were further analyzed with Ligplot, Swiss PDB viewer, and PyMOL. Consequently, molecular
dynamics simulation was utilized to predict the stability of the secondary structure of the antibody
and the binding energy of the scFv antibody to the domain I of exotoxin A.

Results::
As a result, we demonstrated that data from computational biology could provide proteinprotein
interaction information between scFv antibody/domain I exotoxin A and offers new insights
into antibody development and therapeutic expansion.

Conclusions::
In summary, a recombinant human scFv capable of neutralizing P. aeruginosa exotoxin A
is recommended as a promising treatment for infections caused by P. aeruginosa.
An Overview of the Pharmacological Potential of Curcuma longa
Authors: Sharma Prerna , Rani Nidhi , Sharma Anjali , Sharma Vikas , Garg Madhukar 
Published: March 2023

Background:
Various ayurvedic drugs have been widely explored for their therapeutic
potencies since ancient times. One of the most significant medicinal plants is Curcuma longa,
which is one of the different crude medications. It has a variety of beneficial pharmacological characteristics
and has been a staple of Indian cooking for centuries. It exhibits antifungal, antimicrobial,
antioxidant, renal, and hepatoprotective activities. This review is an attempt to explore the various
pharmacological properties of curcumin.

Methods:
This article presents a summary of the methodology available to study the pharmacological
potential, chemical makeup, and organoleptic aspects of Curcuma longa (haldi).

Results:
For its therapeutic properties in Indian material medicine, Curcuma longa is welldocumented.
The plant belongs to the genus Curcuma longa. The Zingiberaceae family includes
Curcuma longa. Curcuma longa is widely used in cosmetics. It is considered the best anthelmintic
property for GIT disorders. In many research papers, curcumin is the best anti-inflammatory agent.
Curcumin is known for its synergistic effect against an anticancer agent. The usefulness of Curcuma
longa as a preventative and curative measure is well established worldwide.

Conclusion:
At general, researchers must consider the experience, cost, and availability of the multidisciplinary
research team, as well as the measures implemented in the institutions, in order to
comprehend the benefits and drawbacks of each assessment method.
Prospectiva de la ingeniería agroindustrial en Iberoamérica al 2035: aplicación de la metodología de escenarios y el método Delphi
Authors: Zartha Sossa Jhon Wilder , Palacio Piedrahita Juan Carlos , Orozco Mendoza Gina Lía , Hincapié Llanos Carlos Augusto , Ríos Mesa Andrés Felipe , Álvarez López Catalina 
Published: March 2023

La ingeniería agroindustrial es una rama de la ingeniería que estudia el aprovechamiento integral de los recursos biológicos para su uso alimentario y no alimentario, dándoles valor agregado por medio de diferentes procesos. El objetivo de este trabajo fue identificar variables clave, priorizar tecnologías, innovaciones, actores, alcanzables y escenarios para la ingeniería agroindustrial a 2035. Se utilizaron métodos y técnicas tales como análisis Pestal, matrices de impacto cruzado (Micmac), matrices traspuestas (Mactor), probabilidades simples, condicionadas positivas y negativas, moda, frecuencia modal y porcentajes de consenso. Entre los resultados más importantes se resalta la identificación de 295 temas como el uso de energías limpias en producción, microencapsulación, fraccionamiento de fluido supercrítico contracorriente, irradiadores uv no térmicos, sonicación, la priorización de tecnologías e innovaciones, tales como la inteligencia artificial, redes convolucionales, algoritmos genéticos, técnicas de lógica difusa con imágenes digitales, mejoramiento de suelos a través de microorganismos y reducción de la contaminación por bioprocesos. Se encontró la participación de 53 expertos de Chile, Perú, México, España y Colombia, 784 justificaciones, 200 problemáticas, 71 variables, 21 drivers, 9 actores, 7 objetivos de futuro, 64 escenarios y la elección de un escenario de apuesta. El uso de los resultados en la consolidación y actualización de proyectos curriculares de ingeniería agroindustrial podría considerar aspectos relacionados con nanotecnología, inteligencia artificial, sostenibilidad, genética, biotecnología y aprovechamiento de residuos, de tal manera que la vigencia de los contenidos este a la par de tecnologías convergentes.
WeChat-Based HIV e-Report, a New Approach for HIV Serostatus Requests and Disclosures Among Men Who Have Sex With Men: Prospective Subgroup Analysis of a Randomized Controlled Trial
Authors: Sun Hai-Tong , Fan Xiao-Ru , Gu Yu-Zhou , Lu Yong-Heng , Qiu Jia-Ling , Yang Qing-Ling , Li Jing-Hua , Gu Jing , Hao Chun 
Published: March 2023

Background
Requesting and disclosing HIV serostatus is associated with a reduction in HIV transmission among men who have sex with men (MSM). However, the reliability of common methods for HIV
serostatus request and disclosure is inadequate. Validated approaches for requesting and disclosing HIV serostatus are necessary.

Objective
The objective of this study was to investigate the use of the HIV e-report as authentic evidence of HIV serostatus among the MSM community in Guangzhou, China. Additionally, the study aimed to explore its correlation with HIV serostatus requesting and disclosure receiving behavior.

Methods
This study is a subgroup analysis of a cluster randomized controlled trial (RCT) that enrolled 357 participants during the first year. Participants in this RCT were recruited from the WeChat-based HIV testing service miniprogram developed by Guangzhou Center for Disease Control and Prevention, China. Participants completed web-based questionnaires at baseline and at the month 3 follow-up, which covered sociodemographic characteristics, HIV-related, HIV serostatus requests, receiving HIV serostatus disclosures, and HIV e-report usage.

Results
The WeChat-based HIV e-report was available in Guangzhou when the RCT project started. At the month 3 follow-up, 32.2% (115/357) of participants had their own HIV e-reports, and 37.8% (135/357) of them had received others’ HIV e-reports. In all, 13.1% (27/205) and 10.5% (16/153) of participants started to use HIV e-reports to request the HIV serostatus from regular and casual male sex partners, respectively. Moreover, 27.3% (42/154) and 16.5% (18/109) of the regular and casual male sex partners, respectively, chose HIV e-reports to disclose their HIV serostatus. Compared to MSM who did not have HIV e-reports, those who had HIV e-reports and stated, “I had had my own HIV e-report(s) but hadn’t sent to others” (multivariate odds ratio 2.71, 95% CI 1.19-6.86; P=.02) and “I had had my own HIV e-reports and had sent to others” (multivariate odds ratio 2.67, 95% CI 1.07-7.73; P=.048) were more likely to request HIV serostatus from their partners. However, no factor was associated with receiving an HIV serostatus disclosure from partners.

Conclusions
The HIV e-report has been accepted by the MSM community in Guangzhou and could be applied as a new optional approach for HIV serostatus requests and disclosures. This innovative intervention could be effective in promoting infectious disease serostatus disclosure among the related high-risk population.

Trial Registration
ClinicalTrials.gov NCT03984136; https://clinicaltrials.gov/show/NCT03984136

International Registered Report Identifier (IRRID)
RR2-10.1186/s12879-021-06484-y
Editorial
Authors: Pacheco-Salazar Berenice 
Published: March 2023

Ciencia y Educación pone a la disposición de la comunidad científica su primer número del 2023 con trabajos de investigación y ensayos teóricos de autoras y autores de México, Honduras y República Dominicana, que abordan temáticas sobre docencia en la educación superior, educación inclusiva, formación en biotecnología y acceso y uso de tecnologías digitales en la juventud indígena...
impact analysis of demographic variables on employee sustainable behavior
Authors: Trivedi Vaishali 
Published: March 2023

The interconnection between profits, people and environment has been well recognized in organizations (Elkington, 1998). With the sustainability issues coming to the forefront, organizations across the world are encouraged to adopt sustainable ways of working aligned to Sustainable Development Goals. Sustainable Behavior of employees at the workplace can play a significant role in strengthening the positive influence of firm’s environmental performance and can lead to the sustainable transition of organization to bring forth sustainable innovations.
The 21st century is said to be IT driven and India promises to be a knowledge powerhouse. IT-BPM (Information technology and Business Process Management) sector accounted for 7.4% of the India's GDP in 2022 and expected to contribute around 10% by 2025, making it one of the biggest contributing sectors to economic growth (IBEF, 2022). It is imperative for the IT sector to develop sustainable IT products to reduce carbon emissions across all sectors of the economy which cannot be achieved without the active pro-environment behavior exhibited by employees. Employee Sustainable Behavior at workplace is still relatively recent subject of research, so this domain lacks studies in the said area.
The present research examines the role that demographic variables play in determining level of employee sustainable behavior among those working in IT sector. The managerial implication of the study focuses on how IT firms can foster sustainable behavior among their employees at the workplace within the demographic context.
Corporate Social Responsibility
Authors: Correa Renata Martins , Thimóteo Antonio Carlos de Alcântara , Varela Carmen Augusta , Junger Alex Paubel , Andrade Sidinei de , Fontana Cristiane Gomes de Carvalho 
Published: March 2023

The present paper approaches Corporate Social Responsibility through a case study concerning Cause Related Marketing, whose concept is defined by strategic partnerships between companies and social organizations. The enterprises invest on the social cause, promoting the corporate social responsibility, whereas the social organizations receive financial resources for their causes, and both gain visibility. Nowadays, it is quite common to find enterprises worldwide which include private social investment in their market strategies to add value and credibility to their brands. However, in Brazil few enterprises are aware of the possibility to use this tool of Cause Related Marketing (CRM). The scope of this study is to understand and clarify the kind of partnership between Alpargatas-Havaianas and Institute of Ecological Research-IPÊ, in Brazil, as well as identify the main challenges of the partnership developed by both. To reach this aim, bibliographic research was performed, followed by document analysis, partially structured in-depth interviews, besides direct observation in some stores. The partnership started in 2004 and showed to have well structured principles of CRM, concerning the alignment between the parties, formal partnership, social cause, donation mode and duration. It was observed that the sales people in the exclusive stores for Havaianas and IPÊ sandals can be more well trained, and communication on the partnership for the consumer can be strengthened. Cause Related Marketing showed to be an important tool for Corporate Social Responsibility.
About the analytical solution for the advertising model of two competing firms
Authors: Sukhinov A. I. 
Published: March 2023

Introduction. The criterion for the success of an advertising campaign is the maximum profit from sales, taking into account the costs of its implementation, while the sale of the same type of goods is sales occur in a competitive environment. The article examines a model for predicting mass sales of two similar products depending on the tactics of an advertising campaign. First of all, the distribution of funds between its separate types is considered: expenses for advertising paper products, banners and advertising in electronic media (EMM).Materials and methods. The model is formulated in the form of a Cauchy problem for a system of two ordinary differential equations with nonlinear right-hand sides, taking into account: the total number of potential solvent buyers of the first and second goods; the intensity of the advertising campaign, mainly through EMM, the positive impact on sales of the interaction of those who have already bought the first or second type of goods with potential buyers, as well as informal (at the level of buyers) anti-advertising.The results of the study. A solution is given for the case of constant coefficients determined by the above factors for the corresponding Cauchy problem in closed form.Discussion and conclusions. The results obtained can be used to replay model situations of advertising organization in order to determine the conditions for extracting the greatest profit from sales minus advertising costs.
The Study of the Relationship of Individual Psychological Characteristics and Self-Expression Strategies in Interpersonal Relationships
Authors: Akhmadeeva E. V. 
Published: March 2023

Introduction. Competent self-expression determines success in planning and promoting the goals of a communicator focused on achieving results in different spheres of life. At the same time, preferred behavioural strategies and personality features are not always apprehended by a person and, consequently, not always used effectively. The urgency to study the problem is due to the insufficient representation of studies of behavioural strategies and individual psychological characteristics of subjects.Purpose. Study of the interrelationships of individual psychological characteristics and behavioural strategies of selfexpression of personality at different stages of professional formation and development.Materials and Methods. The following methodological tools were selected: the methodology for diagnosing the level of reflexivity, the questionnaire Style of Self-Regulation of the Behaviour ― SSB–98, the Test of Affiliation Motives, the Personality Orientation in Communication Test, the Self-Confidence Test, the questionnaire Volitional Qualities in person, the questionnaire Strategies of Self-Expression.Results. Girls prefer the strategy of ‘anxiety to please’ and ‘tracking the impression made’, boys prefer the ‘variability of behaviour’. Women are less likely to track the impression made on the interlocutor and, if necessary, they can dominate and manipulate. Men, in contrast, more closely monitor their behaviour peculiarities and do not tend to show dependence and weakness. Self-confident subjects are characterized by social courage and initiative and apply the ‘self-promotion’ strategy. Dialogical ― strive to be accepted by the target audience, take the initiative. They are not characterized by the strategy of ‘variability of behaviour’. Reflexive subjects are characterized by the use of dialogue and the use of the strategies ‘variability of behaviour’ and ‘self-promotion’.Discussion and Conclusion. It is assumed that the unoften use of the ʻimpression trackingʼ strategy by women is related to the action of the gender education mechanism. It is confirmed that at different stages of age and professional development, behavioural strategies are conditioned by individual psychological characteristics of the personality, which are in demand in the process of self-expression. The data obtained contribute to the theoretical substantiation of the problem and allow us to develop a model of the self-expression of a personality depending on its psychological characteristics.
Equity Strategies in the Design of Student Competency Assessment
Authors: Efremova N. F. 
Published: March 2023

Introduction. The article presents the current situation of the problem under consideration in the works of Russian and foreign authors. The diffi of assessing competencies as complex, deeply latent and interdisciplinary in nature learning outcomes are considered. The study is relevant due to the need to ensure the reliability of estimates. Its novelty lies in the presentation of an algorithm for the development of competence assessment based on the modelling of the construct and conditions for the manifestation of competencies in the process of students’ activities when performing a complex task.Purpose. A systematic presentation of modern approaches to the authentic assessment of competencies based on the theory and practice of pedagogical measurements and experience in designing and using tools based on models of evidencebased argumentation that ensure the fairness of the evaluation process and the authenticity of the evaluation results.Materials and Methods. As theoretical methods, work with sources, collection, generalization, structuring and analysis of information on existing approaches to assessing the students’ competencies in Russia and abroad were used. In the practical part, the experience of organizing and conducting various forms of evaluation of learning outcomes in the context of competence-based learning of students was used.Results. Modern approaches and mechanisms for designing evaluation tools based on models of reasoned proof of evaluation results based on the theory and practice of pedagogical measurements are proposed. Extended pattern designs have been created for teachers, and developers of assessment tools and procedures, ensuring the authenticity of the results through the analysis and interpretation of data, considering contextual information about the activities of the subjects in the assessment situation.Discussion and Conclusion. The interrelation of the problems of competence assessment with their complexity and interdisciplinarity is analyzed, and an appeal to the models of S. Tulmin and R. Mislevi is proposed in the process of developing evaluation tools. The trends in control development and evaluation activities for the measurement of training quality are shown.
Penerapan Algoritma k-Means Clustering untuk Pengelompokan Pembangunan Jalan pada Dinas Pekerjaan Umum dan Penataan Ruang
Authors: Kurniadi Dede , Agustin Yoga Handoko , Akbar Hari Ilham Nur , Farida Ida 
Published: March 2023

Proses penentuan prioritas pembangunan jalan di Dinas Pekerjaan Umum dan Penataan Ruang (PUPR) Kabupaten Garut kurang efektif, baik dalam segi keabsahan dalam mencapai tujuan maupun dalam segi waktu rekap. Hal ini dikarenakan tidak adanya pengelompokan yang baik. Penelitian ini menggunakan metode Cross-Industry Standard Process for Data Mining dan algoritma k-means dalam mengelompokkan data pembangunan jalan dengan atribut jenis, panjang, dan nominal pembangunan. Hasil penelitian ini adalah dipilihnya pengelompokan dengan lima klaster dengan nilai indeks Davies-Bouldin terkecil, yaitu sebesar 0,1617. Analisis karakteristik pembangunan jalan dari klaster terbesar yaitu dari Kelompok 1, Kelompok 2, Kelompok 3, Kelompok 5, dan Kelompok 4, dengan nominal pembangunan bergantung pada jenis pembangunannya. Dari hasil pengetahuan pengelompokan dan karakteristik kelompok, maka Dinas PUPR Kabupaten Garut dapat memprioritaskan pembangunan jalan kecil lebih banyak dibanding pembangunan jalan sedang ataupun besar dengan melihat pengajuan berdasarkan kelompoknya.
Global trends of the research on COVID-19 risks effect in sustainable facility management fields: a bibliometric analysis
Authors: Aladayleh Khaled Jameel , Qudah Shatha Mustafa Abdallah Al , Bargues José Luis Fuentes , Gisbert Pablo Ferrer 
Published: March 2023

AbstractThis study used bibliometric analysis to investigate global research trends regarding the effect of COVID-19 risks in sustainable facility management fields. Between 2019 and 2021, the Scopus database published 208 studies regarding the effect of COVID-19 risks on sustainable facility control fields. VOSviewer software was used to analyse the co-occurrence of all keywords, and Biblioshiny software allowed getting the most relevant affiliation using the three-field plot. The results show the contribution by authors from 51 countries, and 73 keywords were identified and organised into six clusters, such as the effect of COVID-19 risks on human health, supply chain in construction projects and industry, disaster risk management in a changing climate, sustainable supply chain benchmarking, facility management and quality control, and, finally, sensitivity analysis & decision-making.
First-principle study on the effect of S/Se/Te doping and VZn-Hi coexistence on ZnO electrical conductivity
Authors: Gu Yulan , Hou Qingyu , Qi Mude , Yin Xiang , Wang Zhichao 
Published: March 2023

Abstract
In a vacuum environment, when ZnO is prepared using the chemical vapor deposition method and the molecular beam epitaxial growth method, H-gap impurities inevitably remain in the ZnO system, which is often ignored. The study of Zn vacancies under experimental conditions poses a challenge. Second, as an n-type semiconductor, ZnO is characterized by a self-compensation of natural donor defects and poor stability, which severely limit the acquisition of p-type ZnO. Based on the above problems, the conductive properties of S/Se/Te doped and VZn-Hi coexisting ZnO were investigated by first principle to acquire high-stability and high-quality p-ZnO. The study found that Zn35SO35, Zn35SeO35, and Zn35SHiO35 all have good p-type conductivity, which can effectively improve hole mobility and electrical conductivity. Among them, Zn35SO35 has the largest hole concentration at 2.80×1021 cm−3, as well as the best conductivity. The choice of Zn35SO35 provides a reference for obtaining new high-quality p-type ZnO semiconductors.