bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma TRAIL and ANXA1 in diagnosis and prognostication of pulmonary arterial hypertension
Authors: Arvidsson Mattias , Ahmed Abdulla , Säleby Joanna , Ahmed Salaheldin , Hesselstrand Roger , Rådegran Göran 
Published: July 2023

AbstractPulmonary arterial hypertension (PAH) is a rare vasculopathy, with high morbidity and mortality. The sensitivity of the current european society of cardiology/european respiratory society (ESC/ERS) risk assessment strategy may be improved by the addition of biomarkers related to PAH pathophysiology. Such plasma‐borne biomarkers may also reduce time to diagnosis, if used as diagnostic tools in patients with unclear dyspnea, and in guiding treatment decisions. Plasma levels of proteins related to tumor necrosis factor (TNF), inflammation, and immunomodulation were analyzed with proximity extension assays in patients with PAH (n = 48), chronic thromboembolic pulmonary hypertension (PH; CTEPH, n = 20), PH due to left heart failure (HF) with preserved (HFpEF‐PH, n = 33), or reduced (HFrEF‐PH, n = 36) ejection fraction, HF without PH (n = 15), and healthy controls (n = 20). TNF‐related apoptosis‐inducing ligand (TRAIL) were lower in PAH versus the other disease groups and controls (p < 0.0082). In receiver operating characteristics analysis, TRAIL levels identified PAH from the other disease groups with a sensitivity of 0.81 and a specificity of 0.53 [area under the curve: 0.70; (95% confidence interval, CI: 0.61–0.79; p < 0.0001)]. In both single (p < 0.05) and multivariable Cox regression models Annexin A1 (ANXA1) [hazard ratio, HR: 1.0367; (95% CI: 1.0059–1.0684; p = 0.044)] and carcinoembryonic antigen‐related cell adhesion molecule 8 [HR: 1.0603; (95% CI: 1.0004–1.1237; p = 0.0483)] were significant predictors of survival, adjusted for age, female sex and ESC/ERS‐initial risk score. Low plasma TRAIL predicted PAH among patients with dyspnea and differentiated PAH from those with CTEPH, HF with and without PH; and healthy controls. Higher plasma ANXA1 was associated with worse survival in PAH. Larger multicenter studies are encouraged to validate our findings.
Gasless robotic single‐port cholecystectomy using the DaVinci SP system: A feasible way to minimise surgical derangement while obtaining critical view of safety
Authors: Park Sung Eun , Hong Tae Ho 
Published: July 2023

AbstractBackgroundThe aim of this study was to present our initial experience of gasless robotic single‐port cholecystectomy (RSPC).MethodsWe reviewed 48 patients who underwent gasless RSPC with a da Vinci SP Robotic Surgical System. Demographic data, intra‐operative results, and postoperative outcomes were evaluated.ResultsGasless RSPC was successfully performed in 48 of 53 patients. Five patients had conversion to standard pressure pneumoperitoneum due to insufficient surgical space (n = 3), GB perforation (n = 1), or bleeding during surgery (n = 1). The mean whole operation time was 53.6 ± 17.2 min. No patients complained of postoperative shoulder pain or had any postoperative complications. The average hospital stay was 2.1 ± 0.3 days.ConclusionGasless RSPC is feasible and safe. The unique features of an SP robotic platform allow surgeons to perform safely in an incapacious surgical space. However, this procedure is currently only possible for highly selected patients.
Long‐term changes in soil carbon and nitrogen fractions in switchgrass, native grasses, and no‐till corn bioenergy production systems
Authors: Perry Sophie , Falvo Grant , Mosier Samantha , Robertson G. Philip 
Published: July 2023

AbstractCellulosic bioenergy is a primary land‐based climate mitigation strategy, with soil carbon (C) storage and nitrogen (N) conservation as important mitigation elements. Here, we present 13 years of soil C and N change under three cellulosic cropping systems: monoculture switchgrass (Panicum virgatum L.), a five native grasses polyculture, and no‐till corn (Zea mays L.). Soil C and N fractions were measured four times over 12 years. Bulk soil C in the 0–25 cm depth at the end of the study period ranged from 28.4 (± 1.4 se) Mg C ha−1 in no‐till corn, to 30.8 (± 1.4) Mg C ha−1 in switchgrass, and to 34.8 (± 1.4) Mg C ha−1 in native grasses. Mineral‐associated organic matter (MAOM) ranged from 60% to 90% and particulate organic matter (POM) from 10% to 40% of total soil C. Over 12 years, total C as well as both C fractions persisted under no‐till corn and switchgrass and increased under native grasses. In contrast, POM N stocks decreased 33% to 45% across systems, whereas MAOM N decreased only in no‐till corn and by less than 13%. Declining POM N stocks likely reflect pre‐establishment land use, which included alfalfa and manure in earlier rotations. Root production and large soil aggregate formation explained 69% (p < 0.001) and 36% (p = 0.024) of total soil C change, respectively, and 60% (p = 0.020) and 41% (p = 0.023) of soil N change, demonstrating the importance of belowground productivity and soil aggregates for producing and protecting soil C and conserving soil N. Differences between switchgrass and native grasses also indicate a dependence on plant diversity. Soil C and N benefits of bioenergy crops depend strongly on root productivity and pre‐establishment land use.
Core‐Shell Structured hybrid with Photo‐triggered Antibacterial activity for Enhancing Skin Regeneration
Authors: Zhang Bin , Gao Feng , Li Xiaotong , Yuan Jingsong , Bian Weiwei , Zhai Xiaofei , Chu Lichao , Zhao Chunzhen , Zhou Baolong 
Published: July 2023

AbstractOpen wounds infected by bacteria are gearing increasing attention whose treatment are complicated by the appearance of multidrug‐resistant bacteria. Photothermal therapy, kill bacteria through the photothermal conversion, has been extensively studied. Whereas, the high cost and low yield of the active ingredients have limited its widespread use. To address this challenge, the template assisted coating strategy was adopted to prepare a biocompatible photothermal agent, where the hybrid was prepared via in situ copolymerization of 5,10,15,20‐tetrakis(4‐ethynylphenyl)‐21H,23H‐porphine (Por) on the surface of ZIF‐8 template. The introduction of ZIF‐8 in the inner of the hybrid, could not only lower the cost of photosensitizer (i. e., the porphyrin), but also maintain the activity of photosensitizer (PS) finely, which could be used directly as the antimicrobial dressing. In vitro experiments validated the as‐prepared hybrid presents high‐efficiency PTT antibacterial activity. Meanwhile, in vivo chronic wound‐healing experiments on mice verified the as‐synthesized hybrid also delivers excellent anti‐infection and tissue remodeling activities. This work highlights the potential of low‐cost hybrid‐based multifunctional biomaterials in the treatment of skin injuries in clinical settings.
Synthesis and Biological Activities of Novel 1H‐Imidazo[4,5‐b]pyridine Derivatives
Authors: Jebamani Jesurajan , Jayachamarajapura Praneshm Shubha , Shivalingappa Jayadev , Narayanarao Manjunatha , Pasha Mussuvir , Pawar Chandrakant 
Published: July 2023

AbstractWe describe herein an efficient method for synthesizing novel 7‐aryl‐1H‐imidazo[4,5‐b]pyridines 4(a–j) via photocatalytic C(sp2)−C(sp2) cross coupling reaction under mild conditions. We have developed a photocatalytic approach for the synthesis of imidazo[4,5‐b]pyridines with simple reaction steps and good yields. The compounds 4(a–j) were evaluated for antimicrobial activity and showed average to good efficacy against the tested microorganisms. Particularly, compounds 4 b and 4 d exhibited significant antimicrobial activity against both antibacterial and antifungal strains.
Correlating Stokes Shift with Huang‐Rhys Parameter for Diatomic Molecules: Effects of Finite Temperature, Anharmonicity and Breakdown of Franck‐Condon Approximation
Authors: Mitra Subho , De Arijit Kumar 
Published: July 2023

AbstractIn order to compute optical absorption and fluorescence spectra, the harmonic oscillator model for molecular vibrations under Franck‐Condon approximation for optical transition at absolute zero temperature is often considered for ease of numerical simulation, which never truly reproduce the experimental spectra. In this article, we show how systematic introduction of realistic situation, i. e., anharmonicity of vibrations, thermalization and non‐adiabatic transition leading to failure of Franck‐Condon approximation plays a colossal role in determining the spectral shape of a model diatomic molecule. In particular, we investigate how the Huang‐Rhys parameter, describing the relative positioning of the ground and excited electronic surfaces, is correlated with the Stokes shift, considering both right‐ and left‐shifted potential wells, which is crucial to estimate changes in molecular length‐scale from experimentally determined quantities. Further, the result for iodine is shown to have excellent agreement with experimental absorption spectrum. These findings are promised to bring insights into origin of spectral shapes in complex polyatomic molecules.
Gold Nanoparticle‐Carrying T Cells for the Combined Immuno‐Photothermal Therapy
Authors: Kim HyeMi , Baek Yujin , Ha Taeyong , Choi Doowon , Lee Woo Jin , Cho Yongbum , Park Jeehun , Kim Sungjee , Doh Junsang 
Published: July 2023

AbstractCancer immunotherapy is a promising therapy to treat cancer patients with minimal toxicity, but only a small fraction of patients responded to it as a monotherapy. In this study, a strategy to boost therapeutic efficacy by combining an immunotherapy based on ex vivo expanded tumor‐reactive T cells is devised, or adoptive cell therapy (ACT), with photothermal therapy (PTT). Smart gold nanoparticles (sAuNPs), which aggregates to form gold nanoclusters in the cells, are loaded into T cells, and their photothermal effects within T cells are confirmed. When transferred into tumor‐bearing mice, large number of sAuNP‐carrying T cells successfully infiltrate into tumor tissues and exert anti‐tumor activity to suspend tumor growth, but over time tumor cells evade and regrow. Of note, ≈20% of injected doses of sAuNPs are deposited in tumor tissues, suggesting T cells are an efficient nanoparticle tumor delivery vehicle. When T cells no longer control tumor growth, PTT is performed to further eliminate tumors. In this manner, ACT and PTT are temporally coupled, and the combined immuno‐photothermal treatment demonstrated significantly greater therapeutic efficacy than the monotherapy.
A New Family of Layered Metal‐Organic Semiconductors: Cu/V‐Organophosphonates
Authors: Tholen Patrik , Wagner Lukas , Ruthes Jean G. A. , Siemensmeyer Konrad , Beglau Thi Hai Yen , Muth Dominik , Zorlu Yunus , Okutan Mustafa , Goldschmidt Jan Christoph , Janiak Christoph , Presser Volker , Yavuzçetin Özgür , Yücesan Gündoğ 
Published: July 2023

AbstractHerein, we report the design and synthesis of a layered redox‐active, antiferromagnetic metal organic semiconductor crystals with the chemical formula [Cu(H2O)2V(µ‐O)(PPA)2] (where PPA is phenylphosphonate). The crystal structure of [Cu(H2O)2V(µ‐O)(PPA)2] shows that the metal phosphonate layers are separated by phenyl groups of the phenyl phosphonate linker. Tauc plotting of diffuse reflectance spectra indicates that [Cu(H2O)2V(µ‐O)(PPA)2] has an indirect band gap of 2.19 eV. Photoluminescence (PL) spectra indicate a complex landscape of energy states with PL peaks at 1.8 and 2.2 eV. [Cu(H2O)2V(µ‐O)(PPA)2] has estimated hybrid ionic and electronic conductivity values between 0.13 and 0.6 S m−1. Temperature‐dependent magnetization measurements show that [Cu(H2O)2V(µ‐O)(PPA)2] exhibits short range antiferromagnetic order between Cu(II) and V(IV) ions. [Cu(H2O)2V(µ‐O)(PPA)2] is also photoluminescent with photoluminescence quantum yield of 0.02%. [Cu(H2O)2V(µ‐O)(PPA)2] shows high electrochemical, and thermal stability.
Light‐controlled switchable underwater adhesive
Authors: Yang Song , Ma Yanfei , Qin Chenxi , Zhang Zhizhi , Yu Jianqing , Pei Xiaowei , Yu Bo , Sheng Wenbo , Zhou Feng , Liu Weimin 
Published: July 2023

AbstractDespite extensive efforts in designing and preparing switchable underwater adhesives, it is not easy to regulate the underwater adhesion strength locally and remotely. Here, we design and synthesize photoreversible copolymer of poly[dopamine methacrylamide‐co‐methoxyethyl‐acrylate‐co‐7‐(2‐methacryloyloxyethoxy)‐4‐methylcoumarin]. Due to the dynamic formation and breaking of chemical crosslinking networks within the smart adhesives, the material shows widely tunable adhesion strength from ∼150 to ∼450 kPa and long‐range reversible maneuverability under orthogonal 254 and 365 nm ultraviolet light stimulation via the coumarin dimerization and cycloreversion. Moreover, the adhesive exhibits good circulation performance and stability in an acid–base environment. It also demonstrated that the bolt can be coated with the smart adhesive material for on‐demand bonding. This design principle opens the door to the development of remotely controllable high‐performance smart underwater adhesives.
Multi‐Responsive Afterglows from Aqueous Processable Amorphous Polysaccharide Films
Authors: Ren Chunguang , Wang Zhengshuo , Ou Hanlin , Wang Tianjie , Zhao Zhipeng , Wei Yuting , Yuan Hua , Tan Yeqiang , Yuan Wang Zhang 
Published: July 2023

AbstractPolymer‐based room‐temperature phosphorescence (RTP) materials, especially polysaccharide‐based RTP materials, earn sustained attention in the fields of anti‐counterfeiting, data encryption, and optoelectronics owing to their green regeneration, flexibility, and transparency. However, those with both ultralong phosphorescence lifetime and excitation wavelength‐dependent afterglow are rarely reported. Herein, a kind of amorphous RTP material with ultralong lifetime of up to 2.52 s is fabricated by covalently bonding sodium alginate (SA) with arylboronic acid in the aqueous phase. The resulting polymer film exhibits distinguished RTP performance with excitation‐dependent emissions from cyan to green. Specifically, by co‐doping with other fluorescent dyes, further regulation of the afterglow color from cyan to yellowish‐green and near‐white can be achieved through triplet‐to‐singlet Förster resonance energy transfer. In addition, the water‐sensitive properties of hydrogen bonds endow the RTP property of SA‐based materials with water/heat‐responsive characteristics. On account of the color‐tunable and stimuli‐responsive afterglows, these smart materials are successfully applied in data encryption and anti‐counterfeiting.
A unified nonlocal method for capturing discontinuous and multi‐physical behaviors of quasi‐brittle materials
Authors: Yu Haitao , Chen Xizhuo , Sun Yuqi , Hu Xiaokun 
Published: July 2023

AbstractA unified nonlocal method (UNM) is developed to simulate discontinuous and multi‐physical coupling dynamic behaviors for quasi‐brittle materials. In the proposed method, unified nonlocal momentum equations and constitutive laws are proposed to capture the nonlocal fluid transport effect and loading‐rate effect of quasi‐brittle materials. A general multiscale framework, which couples the proposed nonlocal method and the finite element method (FEM), is presented to accelerate the computational efficiency. The effectiveness and accuracy of this method are verified by comparing its results with experimental observations. Numerical examples show that the proposed model can well simulate the discontinuous and multi‐physical behaviors of quasi‐brittle materials, which can serve an effective numerical method for the simulation of engineering problems such as failure of concrete structures.
Understanding the salt overly sensitive pathway in Prunus: Identification and characterization of NHX, CIPK, and CBL genes
Authors: Acharya Biswa R. , Zhao Chaoyang , Reyes Lorenso Antonio Rodriguez , Ferreira Jorge F. S. , Sandhu Devinder 
Published: July 2023

AbstractSalinity is a major abiotic stress factor that can significantly impact crop growth, and productivity. In response to salt stress, the plant Salt Overly Sensitive (SOS) signaling pathway regulates the homeostasis of intracellular sodium ion concentration. The SOS1, SOS2, and SOS3 genes play critical roles in the SOS pathway, which belongs to the members of Na+/H+ exchanger (NHX), CBL‐interacting protein kinase (CIPK), and calcineurin B‐like (CBL) gene families, respectively. In this study, we performed genome‐wide identifications and phylogenetic analyses of NHX, CIPK, and CBL genes in six Rosaceae species: Prunus persica, Prunus dulcis, Prunus mume, Prunus armeniaca, Pyrus ussuriensis × Pyrus communis, and Rosa chinensis. NHX, CIPK, and CBL genes of Arabidopsis thaliana were used as controls for phylogenetic analyses. Our analysis revealed the lineage‐specific and adaptive evolutions of Rosaceae genes. Our observations indicated the existence of two primary classes of CIPK genes: those that are intron‐rich and those that are intron‐less. Intron‐rich CIPKs in Rosaceae and Arabidopsis can be traced back to algae CIPKs and CIPKs found in early plants, suggesting that intron‐less CIPKs evolved from their intron‐rich counterparts. This study identified one gene for each member of the SOS signaling pathway in P. persica: PpSOS1, PpSOS2, and PpSOS3. Gene expression analyses indicated that all three genes of P. persica were expressed in roots and leaves. Yeast two‐hybrid‐based protein–protein interaction analyses revealed a direct interaction between PpSOS3 and PpSOS2; and between PpSOS2 and PpSOS1C‐terminus region. Our findings indicate that the SOS signaling pathway is highly conserved in P. persica.
Sustainable recovery in small businesses: Analysis of sustainable practices and the goals for sustainable development
Authors: Avila Lucas Veiga , Avila Andressa Germann , Kieling Debora Londero , Cavalcante Diego Marques , Lima Clayton Dos Santos 
Published: July 2023

AbstractThis article aims to present the analysis of sustainability practices and the objectives of sustainable development and recovery in small businesses carried out through survey research. The work was based on the understanding of how the theme applies to the objectives of sustainability in small businesses, using the application of a questionnaire in 24 social enterprises of the agribusiness industry in the state of Rio Grande do Sul (RS), present at the largest Fair of Cooperativism in Latin America. The research was exploratory with an approach classified as descriptive, quantitative, and a data survey of 24 valid samples. As a result of the research, it was found that small businesses are focused on the recovery of sustainability, presenting results with significant advances in practical actions of more sustainable and innovative management and with greater cooperation among enterprises. The research makes explicit the possibility of expanding the sample, analyzing small businesses in other regions of the State of Rio Grande do Sul and of the country, with the survey of future research on the theme and case studies in small businesses, expanding the source of evidence to allow a more practical and critical view. Since this is an unprecedented study, the research sought to present to the scientific community the importance of what is currently being produced on the subject, by presenting the innovative and relevant result of the analysis of sustainable recovery in small businesses and sustainable practices.
Dietary strategies in non‐alcoholic fatty liver disease patients: From evidence to daily clinical practice, a systematic review
Authors: Hadefi Alia , Arvanitakis Marianna , Trépo Eric , Zelber‐Sagi Shira 
Published: July 2023

AbstractLifestyle modification comprising calorie restriction (CR) and increased physical activity enabling weight loss is the first‐line of treatment for non‐alcoholic fatty liver disease (NAFLD). However, CR alone is not optimal and evidence suggests that dietary pattern and composition are also critical in NAFLD management. Accordingly, high consumption of red and processed meat, saturated fat, added sugar, and sweetened beverages are associated with an increased risk of developing NAFLD and hepatocellular carcinoma, while other foods and compounds such as fish, olive oil, and polyphenols are, in contrast, beneficial for metabolic disorders. Therefore, several dietary interventions have been studied in order to determine which strategy would be the most beneficial for NAFLD. The evidence regarding the effectiveness of different dietary interventions such as low carbohydrate/low‐fat diet, time‐restricted eating diet, CR, and the well‐studied Mediterranean diet is summarized.
Paroxysmal atrioventricular block in a mixed‐breed dog
Authors: Bastos Pessoa Rebecca , Dayoub Gonçalves Vinícius 
Published: July 2023

AbstractAn 11‐year‐old female mixed‐breed dog was presented with syncopal episodes occurring up to 10 times a day for 3 months. The owner reported events lasting for approximately 15 s, during which the dog would fall into lateral recumbency, have muscle tremors and show intense salivation. After the event, the animal was disorientated for a few seconds before full recovery. A surface electrocardiogram was obtained, during which an episode of syncope occurred, with a paroxysmal atrioventricular block lasting 10.5 s. The event was characterised as an intrinsic pause‐dependent paroxysmal atrioventricular block associated with cardiogenic syncope type 1E. The dog received aminophylline 10 mg/kg every 8 hours and the frequency of syncopal episodes decreased until it died of non‐cardiac causes 3 months later. There is little information on paroxysmal atrioventricular blocks in dogs, and further electrocardiographic event characterisation may the influence choice of therapy in individual cases.
Partition functions of non-Lagrangian theories from the holomorphic anomaly
Authors: Fucito Francesco , Grassi Alba , Morales Jose Francisco , Savelli Raffaele 
Published: July 2023

Abstract
The computation of the partition function in certain quantum field theories, such as those of the Argyres-Douglas or Minahan-Nemeschansky type, is problematic due to the lack of a Lagrangian description. In this paper, we use the holomorphic anomaly equation to derive the gravitational corrections to the prepotential of such theories at rank one by deforming them from the conformal point. In the conformal limit, we find a general formula for the partition function as a sum of hypergeometric functions. We show explicit results for the round sphere and the Nekrasov-Shatashvili phases of the Ω background. The first case is relevant for the derivation of extremal correlators in flat space, whereas the second one has interesting applications for the study of anharmonic oscillators.
A singular perturbation problem for mean field games of acceleration: application to mean field games of control
Authors: Mendico Cristian 
Published: July 2023

AbstractThe singular perturbation of mean field game systems arising from minimization problems with control of acceleration is addressed, that is, we analyze the behavior of solutions as the acceleration costs vanishes. In this setting, the Hamiltonian fails to be strictly convex and coercive w.r.t. the momentum variable and, so, the classical results for Tonelli Hamiltonian systems cannot be applied. However, we show that the limit system is of MFG type in two different cases: we first study the convergence to the classical MFG system and, then, by a finer analysis of the Euler–Lagrange flow associated with the control of acceleration, we prove the convergence to a class of MFG systems, known as, MFG of control.