bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of food distribution resources among military families with young children since the COVID-19 pandemic
Authors: O’Neal Catherine W , Lucier-Greer Mallory , Lewis Crystal , Farnsworth Meredith 
Published: August 2023

AbstractObjective:The present study examined military families’ use of food distribution resources and military (e.g. rank) and non-military (e.g. race/ethnicity) characteristics associated with using food distribution resources.Design:Secondary data analyses from a cross-sectional survey in the first 6 months of 2021.Setting:A national sample of eligible families completed an online survey.Participants:8326 enlisted military families with an active duty service member in the United States Army or Air Force who applied for supplemental childcare funding distributed by National Military Family Association.Results:13·2 % of the families reported utilising a food distribution resource in the past 12 months. Those with lower financial well-being were more likely to utilise such resources. Older (OR = 1·04, 95 % CI = 1·02, 1·05, P < 0·001), single-earner (OR = 0·73, 95 % CI = 0·61, 0·89, P = 0·001) families with a lower rank (OR = 0·69, 95 % CI = 0·64, 0·75, P < 0·001) and Army affiliation (compared with Air Force) (OR = 2·31, 95 % CI = 2·01, 2·67, P < 0·001) were more likely to utilise food distribution resources. Members of certain racial/ethnic minority groups were more likely to utilise food distribution resources than White respondents (OR from 1·47 for multi-racial to 1·69 for Asians), as were families with more dependent children (OR = 1·35, 95 % CI = 1·25, 1·47, P < 0·001).Conclusions:These results identify the extent of food distribution resource utilisation in military families with young children approximately 1 year into the COVID-19 pandemic. The results also identify characteristics associated with their use of food distribution resources. Findings are discussed with an emphasis on prevention and intervention implications for military families.
Satellite Observations and a Numerical Study of Recurring Atmospheric Gravity Waves Along the South China Sea Coast
Authors: Liu Aiyue , Shen Dongliang , Li Xiaofeng 
Published: August 2023

AbstractSeveral groups of diurnal recurring atmospheric gravity waves (AGWs) were observed on an Environmental Satellite advanced synthetic aperture radar image and six Moderate Resolution Imaging Spectroradiometer (MODIS) images acquired along the South China Sea coast for 4 days from 3 to 6 March 2010. The unique observations are that the previously observed AGWs seldom recurred in a region for multiple days. Each cycle of these observed AGWs had undergone three stages: generation, propagation, and dissipation daily. Both SAR‐imaged sea surface roughness patterns and MODIS‐observed cloud imprints show that the AGWs were a group of transverse waves along the coast. We implemented the Weather Research and Forecasting (WRF) model to understand the physical characteristics and dynamical mechanisms of these AGWs. The WRF simulated results indicated that the AGWs were upstream waves triggered by the interaction of the southerly wind and topography and dissipated by the diurnal warming. We applied the spectral analysis to the model‐simulated vertical wind field and explored that the leading wave crest length and crest‐to‐crest wavelength are 156.25 and 7.14 km, respectively. The wave period and phase speed of the upstream AGWs within the vital observation of SAR are 1.81 hr and 1.26 m/s, respectively. The fifth‐generation European Centre for Medium‐Range Weather Forecasts reanalysis hourly data was used to explore the rarity of the recurring AGWs and proved that the stable air‐sea temperature difference was the main reason for the rarity of this event. And sufficient cloud content (>50%) was necessary for the MODIS to capture the AGWs' imprints.
Multidirectional Shifts in Hydrological Connectivity Result From Hydraulic Barriers
Authors: Tan Z. Q. , Yao J. , Gong L. Q. , Li Y. L. , Zhang Q. , Wang X. L. , Wan R. R. , Li B. 
Published: August 2023

AbstractThe weakening of hydrological connectivity caused by hydraulic barriers and its impact on the ecological environment has gained worldwide attention. Previous studies have primarily focused on the obstructive effect of barriers, often overlooking its influence on the internal connectivity of regulated water systems. The study employed a new conceptual framework of hydrological connectivity and utilized the connectivity assessment tool to assess the impact of the proposed Poyang Lake Hydraulic Project (PLHP) on the lake's internal connectivity. The estimated impacts were based on various factors, including the connectivity function (CF), the spatial distribution of the connected object (CONNOB), as well as duration and timing of connection. Key findings indicate that the PLHP will enhance the total connectivity and general connectivity involving inundation depth of the lake. This enhancement will result in increased CF values, expanded CONNOBs and prolonged connection durations. Conversely, the PLHP will weaken the general connectivity involving flow velocity and effective connectivity. As a result, CF values will decrease, CONNOBs will shrink, and connection durations will be shorter. It is important to note that the impact of hydraulic barriers varies depending on evaluation metrics, duration, timing, direction, distance, location, hydrological year, and regulation stage. Therefore, it is not appropriate to simply categorize the barrier impact as “weakening” or “enhancing.” This study innovates the knowledge of hydraulic barriers from the perspective of internal connectivity and is expected to provide more comprehensive theoretical guidance for water resource regulation and eco‐environmental protection.
The Relation Between Dissipation and Memory in Two‐Fluid Displacements in Disordered Media
Authors: Holtzman Ran , Dentz Marco , Planet Ramon , Ortín Jordi 
Published: August 2023

AbstractWe show that the return‐point memory of cyclic macroscopic trajectories enables the derivation of a thermodynamic framework for quasistatically driven dissipative systems with multiple metastable states. We use this framework to sort out and quantify the energy dissipated in quasistatic fluid‐fluid displacements in disordered media. Numerical computations of imbibition–drainage cycles in a quasi‐2D medium with gap thickness modulations (imperfect Hele‐Shaw cell) show that energy dissipation in quasistatic displacements is due to abrupt changes in the fluid‐fluid configuration between consecutive metastable states (Haines jumps), and its dependence on microstructure and gravity. The relative importance of viscous dissipation is deduced from comparison with quasistatic experiments.
A New Framework for Evaluating Model Simulated Inland Tropical Cyclone Wind Fields
Authors: Chen Jie , Gao Kun , Harris Lucas , Marchok Timothy , Zhou Linjiong , Morin Matthew 
Published: August 2023

AbstractThough tropical cyclone (TC) models have been routinely evaluated against track and intensity observations, little work has been performed to validate modeled TC wind fields over land. In this paper, we present a simple framework for evaluating simulated low‐level inland winds with in‐situ observations and existing TC structure theory. The Automated Surface Observing Systems, Florida Coastal Monitoring Program, and best track data are used to generate a theory‐predicted wind profile that reasonably represents the observed radial distribution of TC wind speeds. We quantitatively and qualitatively evaluated the modeled inland TC wind fields, and described the model performance with a set of simple indicators. The framework was used to examine the performance of a high‐resolution two‐way nested Geophysical Fluid Dynamics Laboratory model on recent U.S. landfalling TCs. Results demonstrate the capacity of using this framework to assess the modeled TC low‐level wind field in the absence of dense inland observations.
Nightside High‐Latitude Phase and Amplitude Scintillation During a Substorm Using 1‐Second Scintillation Indices
Authors: Nishimura Y. , Kelly T. , Jayachandran P. T. , Mrak S. , Semeter J. L. , Donovan E. F. , Angelopoulos V. , Nishitani N. 
Published: August 2023

AbstractWe examined evolution of Global Positioning System (GPS) scintillation during a substorm in the nightside high latitude ionosphere, using 1‐s phase and amplitude scintillation indices from the Canadian High Arctic Ionospheric Network (CHAIN) network. The traditional 1‐min scintillation indices showed that the phase scintillation was dominant, while the amplitude scintillation was weak. However, the 1‐s amplitude scintillation occurred more often in association with major auroral structures (polar cap arc, growth phase arc, onset arc, poleward expanding arc, poleward boundary intensification, and diffuse aurora) that were detected by the THEMIS all‐sky imagers (ASIs). The 1‐min index missed much of the amplitude fluctuations because they only lasted ∼10 s near a local peak or at the gradients of the auroral structures. The 1‐s phase scintillation was concurrent with the amplitude scintillation but was much weaker than the 1‐min phase scintillation. The frequency spectral analysis showed that the spectral power above ∼1 Hz was diffractive and below ∼1 Hz was refractive. We suggest that the amplitude scintillation in the high‐latitude ionosphere is much more common than previously considered, and that a short time window of the order of 1 s should be used to detect the scintillation. The 1‐min phase scintillation index is largely influenced by refractive effects due to total electron content (TEC) variations, and the spectral power below ∼1 Hz should be removed to identify diffractive scintillation.
Dissolved Organic Matter Fluorescence as a Tracer of Upwelling and Microbial Activities in Two Cyclonic Eddies in the Eastern Tropical North Atlantic
Authors: Devresse Quentin , Becker Kevin W. , Dilmahamod Ahmad Fehmi , Ortega‐Retuerta Eva , Engel Anja 
Published: August 2023

AbstractMesoscale eddies are frequently observed in the Eastern Tropical North Atlantic (ETNA), yet their effects on the transport and distribution of biogeochemical solutes, and specifically on the production and remineralization of dissolved organic matter (DOM) remain difficult to elucidate. Here, we investigated the submesoscale variability of chromophoric DOM (CDOM) and fluorescent DOM (FDOM) together with microbial production and remineralization processes in two cyclonic eddies (CEs) in the ETNA during summer and winter 2019. One CE, formed near the coast off Mauritania during the post‐upwelling season, was sampled along a ∼900 km zonal corridor between Mauritania and the Cape Verde Islands. The other CE, formed nearby Brava Island, was out of coastal influence. Four fluorescent components were identified with parallel factor analysis, two humic‐like, and two protein‐like components. Humic‐like FDOM components correlated to optode‐based community respiration and were also good indicators of upwelling associated with the Brava Island CE as they correlated to physical parameters (e.g., temperature) and to dissolved inorganic nitrogen. The tryptophan‐like FDOM components correlated with the carbon and nitrogen content of semi‐labile DOM, phytoplankton biomass, community respiration, and bacterial production. Overall, our study revealed that DOM optical properties are suitable for tracing freshly produced organic matter and the transport of remineralized DOM within offshore eddies.
JMJD6 in tumor-associated macrophage regulates macrophage polarization and cancer progression via STAT3/IL-10 axis
Authors: Chen Siyuan , Wang Manni , Lu Tianqi , Liu Yu , Hong Weiqi , He Xuemei , Cheng Yuan , Liu Jian , Wei Yuquan , Wei Xiawei 
Published: August 2023

AbstractThe tumor-associated macrophage (TAM) is the most abundant group of immune cells in the tumor microenvironment (TME), which plays a critical role in the regulation of tumor progression and treatment resistance. Based on different polarization status, TAMs may also induce antitumor immune responses or immunosuppression. The present study identified JMJD6 (Jumonji domain-containing 6) as a novel modulator of TAM activation, the upregulation of which was associated with the immunosuppressive activities of TAMs. JMJD6 deficiency attenuated the growth of both Lewis lung carcinoma (LLC) tumors and B16F10 melanomas by reversing M2-like activation of macrophages, and sensitized tumors to immune checkpoint blockades (ICBs). Moreover, the JMJD6-induced inhibition of M2 polarization was potentially mediated by the STAT3/IL-10 signaling. These findings highlight the regulatory activities of JMJD6 in TAM polarization, and the therapeutic potential of JMJD6/STAT3/IL-10 axis blockades to enhance the efficacy of ICBs in cancer treatment.
BCL-W makes only minor contributions to MYC-driven lymphoma development
Authors: Diepstraten Sarah T. , La Marca John E. , Chang Catherine , Young Savannah , Strasser Andreas , Kelly Gemma L. 
Published: August 2023

AbstractThe BH3-mimetic drug Venetoclax, a specific inhibitor of anti-apoptotic BCL-2, has had clinical success for the treatment of chronic lymphocytic leukaemia and acute myeloid leukaemia. Attention has now shifted towards related pro-survival BCL-2 family members, hypothesising that new BH3-mimetic drugs targeting these proteins may emulate the success of Venetoclax. BH3-mimetics targeting pro-survival MCL-1 or BCL-XL have entered clinical trials, but managing on-target toxicities is challenging. While increasing evidence suggests BFL-1/A1 is a resistance factor for diverse chemotherapeutic agents and BH3-mimetic drugs in haematological malignancies, few studies have explored the role of BCL-W in the development, expansion, and therapeutic responses of cancer. Previously, we found that BCL-W was not required for the ongoing survival and growth of various established human Burkitt lymphoma and diffuse large B cell lymphoma cell lines. However, questions remained about whether BCL-W impacts lymphoma development. Here, we show that BCL-W appears dispensable for MYC-driven lymphomagenesis, and such tumours arising in the absence of BCL-W show no compensatory changes to BCL-2 family member expression, nor altered sensitivity to BH3-mimetic drugs. These results demonstrate that BCL-W does not play a major role in the development of MYC-driven lymphoma or the responses of these tumours to anti-cancer agents.
Engineered inhaled nanocatalytic therapy for ischemic cerebrovascular disease by inducing autophagy of abnormal mitochondria
Authors: Wang Deping , Li Bowen , Wang Shuchao , Hao Yingjian , Wang Hua , Sun Wei , Cao Jimin , Zhou Xin , Zheng Bin 
Published: August 2023

AbstractMitochondrial dysfunction and subsequent accumulation of reactive oxygen species (ROS) are key contributors to the pathology of ischemic cerebrovascular disease. Therefore, elimination of ROS and damaged mitochondria is crucial for the effective treatment of this disease. For this purpose, we designed an inhalation nanotherapeutic agent, P/D@Mn/Co3O4, to treat ischemic cerebrovascular disease. Mn/Co3O4 effectively removed excess ROS from cells, reduced acute cellular oxidative stress, and protected neural cells from apoptosis. Furthermore, it depleted the H+ surrounding mitochondria and depolarized the mitochondrial membrane potential, inducing mitophagy and eliminating abnormal mitochondria, thereby avoiding the continuous overproduction of ROS by eliminating the source of ROS regeneration. On intranasal administration, Mn/Co3O4 encapsulated by platelet membranes and 2,3-(dioxy propyl)-trimethylammonium chloride can bypass the blood–brain barrier, enter the brain through the trigeminal and olfactory pathways, and target inflammatory regions to remove ROS and damaged mitochondria from the lesion area. In rat models of stroke and vascular dementia, P/D@Mn/Co3O4 effectively inhibited the symptoms of acute and chronic cerebral ischemia by scavenging ROS and damaged mitochondria in the affected area. Our findings indicate that the nanotherapeutic agent developed in this study can be used for the effective treatment of ischemic cerebrovascular disease.
A genome-wide by PM10 exposure interaction study for blood pressure in Korean adults
Authors: Kim Hyun-Jin , Son Ho-young , Park Philiip , Yun Jae Moon , Kwon Hyuktae , Cho Belong , Kim Jong-Il , Park Jin-Ho 
Published: August 2023

AbstractBlood pressure (BP) is a typical complex trait, and the genetic susceptibility of individuals to changes in BP induced by air pollution exposure is different. Although interactions of exposure to air pollutants with several candidate genes have been identified, genome-wide interaction studies (GWISs) are needed to understand the association between them with BP. Therefore, we aimed to discover the unique genetic loci for BP that interact with exposure to air pollutants in Korean adults. We ultimately included 1868 participants in the discovery step and classified them into groups of those with low-to-moderate exposure and high exposure to average annual concentration of particulate matter with an aerodynamic diameter ≤ 10 μm (PM10). Because none of the single nucleotide polymorphisms (SNPs) achieved a genome-wide level of significance of pint < 5 × 10–8 for either systolic BP (SBP) or diastolic BP (DBP), we considered the top 10 ranking SNPs for each BP trait. To validate these suggestive SNPs, we finally selected six genetic variants for SBP and five variants for DBP, respectively. In a replication result for SBP, only one SNP (rs12914147) located in an intergenic region of the NR2F2 showed a significant interaction. We also identified several genetic susceptibility loci (e.g., CHST11, TEK, and ITGA1) implicated in candidate mechanisms such as inflammation and oxidative stress in the discovery step, although their interaction effects were not replicated. Our study reports the first GWIS finding to our knowledge, and the association between exposure to PM10 and BP levels may be determined in part by several newly discovered genetic suggestive loci, including NR2F2.
Adherence to inhaled corticosteroids in patients with asthma prior to and during the COVID-19 pandemic
Authors: Rodríguez Isabel , López-Caro Juan Carlos , Gonzalez-Carranza Silvia , Cerrato Maria Elena , De Prado Maria Mar , Gomez-Molleda Francisca , Pinel Margarita , Saiz Maria Teresa , Fuentes Carmen , Barreiro Esther , Santibáñez Miguel 
Published: August 2023

AbstractThe electronic prescription refill rate (EPRR) of 183 consecutive patients was determined over a 19-month retrospective study period, divided into 7 months PRE (Sep-19 to Mar-20) and 12 months POST pandemic (Apr-20 to Mar-21), in order to compare adherence to inhaled corticosteroids (ICS) in patients with asthma prior to and during the COVID-19 pandemic. Before the pandemic (PRE), an average of 0.58 inhalers/month were refill from the pharmacy; [SD 0.33], very similar to the 0.59 inhalers/month; [SD 0.34] retrieved during the 12 subsequent months since the pandemic (POST) (p = 0.768). EPRR showed no differences (p = 0.784). When EPRR was dichotomous or ordinal categorised no differences were found either (p = 0.851 and 0.928), even when McNemar's test was used (p = 0.949), with prevalences of nonadherence (EPRR < 80%) of 57 and 58% respectively. Our results do not support increased adherence to inhaler treatment in terms of EPRR, comparing before and since COVID-19 pandemic. Compliance with prescription remains suboptimal.
Comparative analysis of effectiveness for phage cocktail development against multiple Salmonella serovars and its biofilm control activity
Authors: Ribeiro Jhonatan Macedo , Pereira Giovana Nicolete , Durli Junior Itamar , Teixeira Gustavo Manoel , Bertozzi Mariana Marques , Verri Waldiceu A. , Kobayashi Renata Katsuko Takayama , Nakazato Gerson 
Published: August 2023

AbstractFoodborne diseases are a major challenge in the global food industry, especially those caused by multidrug-resistant (MDR) bacteria. Bacteria capable of biofilm formation, in addition to MDR strains, reduce the treatment efficacy, posing a significant threat to bacterial control. Bacteriophages, which are viruses that infect and kill bacteria, are considered a promising alternative in combating MDR bacteria, both in human medicine and animal production. Phage cocktails, comprising multiple phages, are commonly employed to broaden the host range and prevent or delay the development of phage resistance. There are numerous techniques and protocols available to evaluate the lytic activity of bacteriophages, with the most commonly used methods being Spot Test Assays, Efficiency of Plating (EOP), and infection assays in liquid culture. However, there is currently no standardization for which analyses should be employed and the possible differences among them in order to precisely determine the host range of phages and the composition of a cocktail. A preliminary selection using the Spot Test Assay resulted in four phages for subsequent evaluation against a panel of 36 Salmonella isolates of numerous serovars. Comparing EOP and infection assays in liquid culture revealed that EOP could underestimate the lytic activity of phages, directly influencing phage cocktail development. Moreover, the phage cocktail containing the four selected phages was able to control or remove biofilms formed by 66% (23/35) of the isolates, including those exhibiting low susceptibility to phages, according to EOP. Phages were characterized genomically, revealing the absence of genes associated with antibiotic resistance, virulence factors, or integrases. According to confocal laser scanning microscopy analysis, the biofilm maturation of one Salmonella isolate, which exhibited high susceptibility to phages in liquid culture and 96-well plates biofilm viability assays but had low values for EOP, was found to be inhibited and controlled by the phage cocktail. These observations indicate that phages could control and remove Salmonella biofilms throughout their growth and maturation process, despite their low EOP values. Moreover, using infection assays in liquid culture enables a more precise study of phage interactions for cocktail design timelessly and effortlessly. Hence, integrating strategies and techniques to comprehensively assess the host range and lytic activity of bacteriophages under different conditions can demonstrate more accurately the antibacterial potential of phage cocktails.
Antimicrobial activity of Spirulina platensis extract on total mesophilic and psychrophilic bacteria of fresh tilapia fillet
Authors: Metekia Wubshet Asnake , Ulusoy Beyza Hatice 
Published: August 2023

AbstractSpirulina platensis has a wide range of activities, notably antibacterial property against food pathogens. This study investigates the antibacterial activity of S. platensis extract on Total Mesophilic and Psychrophilic Aerobic Bacteria. The results were compared using statistical analysis and the predicted model values using artificial intelligence-based models such as artificial neural network (ANN) and adaptive neuro fuzzy inference system (ANFIS) Models. The extraction of spirulina was done by using the freeze–thaw method with a concentration of 0.5, 1 and 5% w/v. Before the application of the extract, initial microbial load of fillets was analyzed the and the results were used as control. After application analysis was performed at 1, 24 and 48 h of storage at 4 °C. Based on the statistical analysis result the S. platensis extracts’ antimicrobial activity over TMAB of fresh tilapia fish fillets at 1, 24 and 48 h was using EA from 2.5 log10 CFU/g during the control stage to 1.8, 1.1 and 0.7 log10 CFU/g respectively whereas EB and EC was from 2.1 and 2.2 log10 CFU/g at control to 1.5, 0.8, 0.5 log10 CFU/g and 1.23, 0.6 and 0.32 log10 CFU/g respectively at the specified hour interval. Similarly, the three extracts over TPAB were from 2.8 log10 CFU/g at control time to 2.1, 1.5 and 0.9 in EA, while using EB reduces from 2.8 log10 CFU/g to 1.9, 1.3 and 0.8 log10 CFU/g at 1, 24 and 48 h respectively. Although EC presented the reduction from 1.9 log10 CFU/g to 1.4, 1 and 0.5 log10 CFU/g. This was supported by ANN and ANFIS models prediction.