bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Investigation of Color Doppler Ultrasonography Parameters
of the Uterine Artery in Patients with Post-molar GTN and Patients
Recovered from Molar Pregnancy and its Role in Predicting the Probability
of Occurrence
Authors: Hasanzadeh Malihe , Jahani Najmeh , Mirzaeian Sara , Esmaeilpour Maryam , Farazestanian Marjaneh 
Published: May 2023

Objectives:
Hydatiform mole can progress to gestational trophoblastic neoplasia (GTN),
and we are looking for non-invasive methods to predict it. Old age, higher serum BHCG levels, and
expression of genes, such as VEGF-EG, HIF-1α, and TGF-ß are known as predictive factors. We performed
this study to evaluate the role of bilateral uterine artery doppler ultrasound in predicting postmolar-
GTN.

Methods:
In this prospective cohort study, 42 patients with complete molar pregnancy were examined.
Inclusion criteria confirmed molar pregnancy by histopathological examination. Exclusion criteria
were patients more than 40 years old, patients with completed family childbearing planning, and diagnosis
of GTN during the routine histopathological study. Before molar evacuation and four weeks later,
bilateral uterine artery doppler sonography to determine the PI, RI, and PSV was performed. Serum
BHCG levels were also measured before molar evacuation and weekly after evacuation until it exhibited
spontaneous remission or developed GTN.

Results:
About 36 patients were cured, and six others developed post-molar GTN. The bilateral uterine
artery doppler sonography between the two groups showed a lower UA RI in the post-molar-GTN
group before evacuation (P=0.048). Data demonstrated significant increases in Right.UA.RI
(P=0/008), Left.UA.PI (P=0/037), and Right.UA.PSV (P=0/024) in the spontaneous remission group
during 28 days follow-up period. There were no significant differences in these parameters in the GTN
group throughout the time of follow-up.

Conclusion:
It seems that Doppler ultrasound plays a role in predicting GTN following uterine evacuation.
A lower resistance in the uterine artery before evacuation and the remaining uterine artery blood flow constant
after evacuation is associated with the development of post-molar- GTN.
Quality by Design Enabled Formulation Optimization of Rabeprazole
Sodium Mucoadhesive Microcapsules for the Treatment of Gastroesophageal
Reflux Disease
Authors: Panda Jayanti , Swain Suryakanta , Bhanoji Rao Muddana Eswara 
Published: May 2023

Aims:
The present research describes the implementation of quality by-design principles for
developing the mucoadhesive microcapsules of rabeprazole sodium for treating gastroesophageal reflux
disease conditions.

Background:
In addition, a holistic QbD-based product development strategy was implemented,
where the target product profile was defined based on desired product quality of mucoadhesive microcapsules.
Based on TPP, the critical quality attributes were identified. The identification of CMAs was
carried out with the help of risk assessment and factor screening exercises, which indicated drugpolymer
ratio (X1), temperature (X2), and stirring speed (X3) as the influential factors.

Methods:
The mucoadhesive microcapsules of rabeprazole sodium were prepared by a solvent evaporation
method, and 33 Box-Behnken optimization design was used for the optimization of the selected
factors, and mucoadhesive microcapsules formulations were evaluated for particle size (μm), drug entrapment
efficiency (%), mucoadhesion (%), and in vitro drug release (Q18h) in percentage characteristics.
Mathematical data analysis was performed to fit the two-factor interaction model, and optimized
mucoadhesive microcapsules formulation was selected.

Results:
The optimized mucoadhesive microcapsules indicated desired formulation characteristics
with smaller particle size, good entrapment efficiency, better mucoadhesion, and sustained drug release
characteristics.

Conclusion:
In a nutshell, the studies vouch for the successful development of mucoadhesive microcapsules
for oral delivery of rabeprazole sodium which could be used to manage gastroesophageal reflux
disease condition.
Therapeutic Repurposing of Antidiabetic Drugs in Diabetes-associated
Comorbidities
Authors: Pathak Kalyani , Pathak Manash Pratim , Saikia Riya , Gogoi Urvashee , Das Ratna Jyoti , Patowary Pompy , Kaishap Partha Pratim , Bordoloi Smita , Das Jyotirmoy , Sarma Himangshu , Ahmad Mohammad Zaki , Das Aparoop 
Published: May 2023

Background:
Diabetic patients suffer from various comorbidities like cardiovascular diseases
(CVDs), cancer, obesity, cognitive impairment, gout, leishmaniasis, etc.

Objective:
We aimed to review the pathological links between diabetes and its comorbidities and discuss
the justification for using antidiabetic drugs in diabetes and associated comorbidities.

Methods:
Diabetic patients accompanied by comorbidities had to undergo a multidrug regimen apart
from their common antidiabetic drugs, which affects their quality of life. There have been reports that
some antidiabetic drugs ameliorate the comorbidities associated with diabetes. For instance, metformin
is implicated in CVDs, cancer, as well as in cognitive impairment like Alzheimer's disease (AD);
glyburide, a sulfonylurea, is found to be effective against leishmaniasis; and voglibose, an α-
glucosidase inhibitor, is found to have suitable binding property against SARS-CoV-2 infection in diabetic
patients. Targeting the comorbidities of diabetes with antidiabetic drugs may reduce the load of
multidrug therapy in diabetic patients.

Results:
The effectiveness of antidiabetic drugs against some diabetic comorbidities between the two
pathophysiological conditions, i.e., diabetes and its comorbidities, may be due to certain bidirectional
links like inflammation, oxidative stress, disruption in the metabolic milieu and obesity. There are
published reports of the repurposing of antidiabetic drugs for specific diseases, however, compiled repurposed
reports of antidiabetic drugs for a wide range of diseases are scarce.

Conclusion:
In this review, we attempt to justify the use of antidiabetic drugs in diabetes and associated
comorbidities.
Methotrexate-induced Severe Pancytopenia in a Patient with Rheumatoid
Arthritis: A Case Report and Review of Literature
Authors: Hosseini Elham , Shahbazi Foroud 
Published: May 2023

Abstract:
Toxicity associated with low doses of methotrexate (MTX) is low, but it may be fatal.
Bone marrow suppression and mucositis are among the common side effects of low dose MTX
toxicity. Different risk factors have been reported for toxicities associated with low doses of MTX,
including accidental use of higher doses, renal dysfunction, hypoalbuminemia, and polypharmacy.
In this paper, we present a female patient who had mistakenly used 7.5 mg of MTX daily instead of
the same dose of MTX on Thursday and Friday. She was presented with mucositis and diarrhea to
the emergency department. Moreover, we searched the databases Scopus and PubMed for available
studies and case reports on toxicities associated with MTX dosing errors. The most frequently observed
toxicities included gastrointestinal lesions, nausea, vomiting, skin lesions, and bone marrow
suppression. Leucovorin, hydration, and urine alkalinization were among the most frequently used
treatments. Finally, we summarize the data on the toxicities of low doses of MTX in different diseases.
Prognostic Value of Fatty Acid Metabolism-related Genes in Patients with
Bladder Cancer
Authors: Huang Qiuzheng , Li Zhijia , Liu Chao 
Published: May 2023

Introduction:
This study aimed to explore the expression profiles of fatty acid metabolism-
related genes (FAMRGs) in patients with bladder cancer (BLCA).

Methods:
The corresponding clinicopathological features of BLCA patients and RNA sequencing
data were downloaded from TCGA and GSE13507. Univariate Cox regression was used to determine
the prognostic value of FRGS in BLCA patients. LASSO regression analysis was then performed
to select potential risk genes and eliminate genes that might overfit the model. Based on
the independent prognostication-related FRGs, the nomogram survival model was established using
the root mean square value of the R packet to predict the 1-year, 3-year, and 5-year survival
rates of BLCA patients. By determining the area under the curve (AUC) value, the time-dependent
receiver operating characteristic curve (ROC) was used to evaluate the prognostic efficiency of
our model.

Results:
A total of 243 DEFRGs were identified. Twenty FRGs were found to be related to the
prognosis of BLCA in the TCGA database. Survival curves showed that high-risk patients had
significantly shorter OS than low-risk cases (p < 0.001). The AUC of risk was 0.784, which was
superior to age, sex, and stage, suggesting that the risk score was more favorable in predicting OS
than traditional pathologic prognostic factors. The AUC was 0.757 at 1 year, 0.732 at 3 years, and
0.733 at 5 year-OS.

Conclusion:
In this study, we demonstrated that a FAMRG prognosis biomarker is associated
with the tumor immune microenvironment in patients with BLCA.
Trauma-Informed Care in Digital Health Technologies: Protocol for a Scoping Review
Authors: Abdulai Abdul-Fatawu , Naghdali Hasti , Tekie Ghirmay Eden , Adam Fuseini , Bawafaa Eunice 
Published: May 2023

Background
The use of digital health technologies is becoming increasingly common across the globe as they offer immense potential to enhance health care delivery by promoting accessibility, flexibility, and personalized care, connecting patients to health care professionals, and offering more efficient services and treatments to remote residents. At the same time, there is an increasing recognition of how digital health can inadvertently foment psychological trauma. This phenomenon has led to the adoption of trauma-informed care in designing and deploying digital health technologies. However, how trauma-informed care is defined and characterized, and the various trauma-informed care strategies used in designing and deploying digital health technologies remain unexplored.

Objective
This scoping review aims to explore and synthesize the literature on how trauma-informed care is defined and characterized in digital health and the various trauma-informed care principles, strategies, or recommendations used in designing and deploying digital health.

Methods
This review will draw on the Joanna Briggs Institute’s updated methodological guidance for scoping reviews. A search will be conducted on CINAHL, PubMed, Embase, Compendex Engineering Village, Web of Science, Scopus, and PsycINFO. This review will consider published research studies and unpublished work (gray literature). Studies will be included if they applied trauma-informed care in designing or deploying digital health for patients across all geographical locations or provide trauma-informed recommendations on how web developers should develop digital health. Studies will be limited to publications within the past 10 years and studies in all languages will be considered. Two independent reviewers will screen the titles and abstracts, and then perform a full-text review. Data will be extracted into a data extraction tool developed for this study.

Results
The scoping review was undergoing a full search as of April 2023. The main results will synthesize the peer-reviewed and gray literature on adopting trauma-informed care practices in digital health research and development. The study is expected to be completed by December 2023 and the results are expected to be published in a peer-reviewed journal.

Conclusions
This review is expected to provide the knowledge base on the adoption of trauma-informed care in designing and deploying digital health. This knowledge can lead to more engaging, and likely, more effective digital health interventions that have less potential for harm. A synthesis of the various trauma-informed care strategies in digital health will also provide a trauma-informed language by enabling researchers and digital health developers to consider trauma as a critical factor in each stage of the design process.

International Registered Report Identifier (IRRID)
DERR1-10.2196/46842
Global Prevalence of Prediabetes
Authors: Rooney Mary R. , Fang Michael , Ogurtsova Katherine , Ozkan Bige , Echouffo-Tcheugui Justin B. , Boyko Edward J. , Magliano Dianna J. , Selvin Elizabeth 
Published: May 2023

OBJECTIVE
To estimate the global, regional, and national prevalence of prediabetes, defined by impaired glucose tolerance (IGT) or impaired fasting glucose (IFG).

RESEARCH DESIGN AND METHODS
We reviewed 7,014 publications for high-quality estimates of IGT (2-h glucose, 7.8–11.0 mmol/L [140–199 mg/dL]) and IFG (fasting glucose, 6.1–6.9 mmol/L [110–125 mg/dL]) prevalence for each country. We used logistic regression to generate prevalence estimates for IGT and IFG among adults aged 20–79 years in 2021 and projections for 2045. For countries without in-country data, we extrapolated estimates from countries with available data with similar geography, income, ethnicity, and language. Estimates were standardized to the age distribution for each country from the United Nations.

RESULTS
Approximately two-thirds of countries did not have high-quality IGT or IFG data. There were 50 high-quality studies for IGT from 43 countries and 43 high-quality studies for IFG from 40 countries. Eleven countries had data for both IGT and IFG. The global prevalence of IGT in 2021 was 9.1% (464 million) and is projected to increase to 10.0% (638 million) in 2045. The global prevalence of IFG in 2021 was 5.8% (298 million) and is projected to increase to 6.5% (414 million) in 2045. The 2021 prevalence of IGT and IFG was highest in high-income countries. In 2045, the largest relative growth in cases of IGT and IFG would be in low-income countries.

CONCLUSIONS
The global burden of prediabetes is substantial and growing. Enhancing prediabetes surveillance is necessary to effectively implement diabetes prevention policies and interventions.
Leucine supplementation ameliorates early life “programming” of obesity in rats
Authors: Sun Yuchen , Sun Bo , Han Xuesong , Shan Anshan , Ma Qingquan 
Published: May 2023

<p> </p>
<p>The advanced cessation of lactation elevates the risk of programmed obesity and obesity-related metabolic disorders in adulthood. The study used multi-omics analysis to investigate the mechanism behind this phenomenon and the effects of leucine supplementation on ameliorating programmed obesity development. Wistar/SD rat offspring were subjected to early weaning (EW) at d 17 (EWWIS and EWSD groups) or normal weaning at d 21 (CWIS and CSD groups). Half rats from the EWSD group were selected to create a new group with two-month leucine supplementation at d 150. The results showed that EW impaired lipid metabolic gene expressions and increased insulin, neuropeptide Y, and feed intake, inducing obesity in adulthood. Six lipid metabolism-related genes (<em>Acot1</em>, <em>Acot2</em>, <em>Acot4</em>, <em>Scd</em>, <em>Abcg8</em>, and <em>Cyp8b1</em>) were influenced by EW during the whole experimental period. Additionally, adult early-weaned rats exhibited cholesterol and fatty acid β-oxidation disorders, liver taurine reduction, cholestasis, and insulin and leptin resistance. Leucine supplementation partly alleviated these metabolic disorders and increased liver L-carnitine, retarding programmed obesity development. This study provides new insights into the mechanism of programmed obesity development and the potential benefits of leucine supplementation, which may offer suggestions for life planning and programmed obesity prevention.</p>
Cimentos fictícios da Cidade Penitenciária
Authors: Alvo Luis González 
Published: May 2023

In 1937, a prison reform project called Cidade Penitenciária do Rio de Janeiro was published for the then capital of Brazil. From the architectural point of view, the “prison city” did not present significant differences from other prisons of the time. Nor was it presented as a kind of urbanization project. The proposal of its author, the architect Adelardo Caiuby, drew on his experience as the creator of the Model Leprosarium of São Paulo (1918), whose main idea was to allow long-time inmates in the hospital to lead a life similar to the one they had out of isolation. In theory, Caiuby tried to transfer this idea to the penitentiary sphere, although he did it with a traditional architectural prison design. In the article, we delve into the meanings of the metaphor of the city that some state agents deemed adequate to solve the problems of incarceration. What were prison conditions like in the Federal District in 1930? Who were the agents in charge of seeking solutions? What experiences did they have? What was the specific operating proposal for this city? How did it differ from other existing prisons? These are some of the questions raised in the article. It different from other existing prisons? These are some of the questions that guide this work.
PENGARUH MODEL PEMBELAJARAN SCIENTIFIC INQUIRY TERHADAP KETERAMPILAN PROSES SAINS SISWA PADA MATERI POKOK SUHU DAN KALOR
Authors: Putri Heline , Harahap Mara Bangun 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Scietific Inquiry terhadap keterampilan proses sains siswa pada materi pokok Suhu dan Kalor. Metode penelitian adalah quasi eksperimen dengan desain control group pretest-postest design. Sampel penelitian ini diambil dengan teknik cluster random sampling yang terdiri dari dua kelas yaitu kelas eksperimen dan kelas kontrol. Hasil analisa data pretes diperoleh rata-rata kelas eksperimen 20,93 dengan standard deviasi 5,297 dan rata-rata kelas kontrol 20,80 dengan standard deviasi 5,270. Pada uji normalitas dan homogenitas kedua kelas berdistribusi normal dan homogen artinya kedua kelas memiliki kemampuan awal yang sama. Selanjutnya dilakukan postes pada kedua kelas. Untuk kelas eksperimen diperoleh rata-rata 82,13 dengan standard deviasi 5,480 dan untuk kelas kontrol diperoleh rata-rata 70,73 dengan standard deviasi 5,240. Hasil penelitian menunjukkan keterampilan proses sains siswa dengan model pembelajaran Scientific Inquiry lebih tinggi dari pada keterampilan proses sains siswa dengan pemeblajaran konvensional. Hasil uji t postes diperoleh thitung > ttabel = 8,261>1,671. sehingga Ha diterima yang menunjukkan pengaruh model pembelajaran Scientific Inquiry terhadap keterampilan proses sains siswa pada materi Suhu dan Kalor di kelas XI semester I SMA Swasta Santa Maria Medan.
RANCANGAN MEDIA PEMBELAJARAN FISIKA BERBASIS WEBSITE PADA MATERI POKOK FLUIDA DINAMIS KELAS XI
Authors: Haloho Khairul Hasyim , Tanjung Ratna , Sudarma Teguh Febri 
Published: May 2023

Penelitian ini bertujuan untuk merancang media pembelajaran fisika berbasis website pada materi pokok fluida dinamis kelas XI. Penelitian ini termasuk jenis penelitian pengembangan. Sample pengujian media adalah kelas XI MIA 4 dan kelas XII IPA 2 SMA Negeri 13 Medan. Data yang digunakan dalam penelitian adalah data hasil angket validasi dan analisis respon siswa. Hasil validasi dari ahli media terhadap media pembelajaran memperoleh rata – rata 94,81% dinilai sangat baik, hasil validasi dari ahli materi terhadap materi pembelajaran memperoleh 94,00% Hasil respon siswa terhadap pada uji coba kelas kecil dinilai sangat baik dengan rata – rata 91,22% dan respon siswa pada uji coba lapangan memperoleh rata - rata 93.00%. Dengan media pembelajaran fisika berbasis website pada materi pokok fluida dinamis kelas XI memenuhi kriteria kelayakan media pembelajaran.
Uji Kelayakan Media Pembelajaran Fisika Multimedia Interaktif Berbasis Powtoon Pada Materi Momentum dan Impuls
Authors: SITOHANG RIKARDO - , Megalina Yeni 
Published: May 2023

Penelitian pengembangan ini bertujuan untuk mengembangkan media pembelajaran fisika multimedia interaktif pada materi pokok momentum dan impuls yang layak untuk diterapkan dalam proses pembelajaran fisika di sekolah dan mengetahui respon mahamahasiswa setelah menggunakan mutimedia interaaktif yang dikembangkan. Subjek dalam penelitian ini adalah mahamahasiswa kelas Fisika Dik D 2017, Jurusan Fisika, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas berjumlah 15 orang mmahasiswa. Jenis penelitian ini merupakan penelitian pengembangan atau Research and Development (R&D) menggunakan 4D Models. Instrumen yang digunakan dalam penelitian ini terdiri dari angket validasi ahli media, dan angket respon peserta didik terhadap multimedia interaktif fisika berbasis powtoon. Teknik analisis data yang digunakan dalam penelitian ini adalah deskriptif. Dari hasil analisis data diperoleh validasi ahli media pembelajaran 71,6% dengan presentese tersebut termasuk dalam kategori baik. Sedangkan pada uji coba luas persentase respon mahasiswa dengan sampel 15 orang sebesar 86,06% dengan kriteria sangat baik, sehingga berdasarkan hasil validasi dan respon peserta didik dapat disimpulkan multimedia interaktif fisika berbasis powtoon pada materi pokok momentum dan impuls layak digunakan dalam proses pembelajaran
Analysis of digital humanistic knowledge production based on natural language processing
Authors: Pan Liurong , Alshalabi Riyad , Li Pingfen , Naminse Eric Yaw , Tan Fuqiang 
Published: May 2023

Abstract
Digital humanistic knowledge production emphasises the importance of a strong knowledge production community and differentiates from traditional knowledge production models, which include aspects such as online and cooperative knowledge development. The digital humanities knowledge production community model is already widely acknowledged. However, the features and characteristics of digital humanistic knowledge production under natural language processing are controversial. This research presents a wordVEA digital humanistic knowledge production feature mining approach based on a word2vec and variational self-encoder (VAE). The knowledge production characteristics of digital humanistic are primarily defined by the coexistence of a knowledge production structure and boundary blurring, as well as interdisciplinary collaboration thematic cohesiveness and broad horizon, as determined by the research results which effectively address the question of the characteristics of digital humanistic knowledge production through application of the word VAE method.
Effects of Dietary Supplementation of Peppermint Extract on Growth Performance, Intestinal Microbiota, Liver and Intestine Histopathology of Cyprinus carpio
Authors: Baghalian Ali , Shahsavani Davar , Roshanak Sahar , Alidadi Soodeh , Paolucci Marina , Motlagh Hamidreza Ahmaniaye 
Published: May 2023

Abstract
This study aimed to evaluate the effects of Mentha piperita methanolic extract (MPE) on Cyprinus carpio intestinal microbiota, including total microorganisms gram-negative bacteria, lactic acid bacteria, and fungi count. Liver and intestinal histopathology, and the activity of liver enzymes, were also used to evaluate the possible side effects of MPE. A total of 96 healthy C. carpio fries (76.76±20.26 g) were allocated to four treatment groups with three replications in a completely randomized design. The fries were fed with diets containing 0, 0.5, 1, and 2% extract for 56 days at the rate of 2% of body weight during the experiment. Results showed a significant decrease in total microorganisms, enteric gram-negative bacteria, and total fungi counts (p<0.05). The total lactic acid bacteria count in 0.5% treatment was significantly lower than in control and 2% treated fish (P<0.05). MPE did not affect AST, leading to a significant increase in ALT levels. Simultaneously, ALP represented significantly higher activity in the control group (P>0.05). Microscopic findings revealed marked lesions, including congestion and cell degeneration in the livers of the three groups of fish fed with the extract. The intestinal folds were shortened and blunted in the treatment groups. Furthermore, the intestinal mucosa was necrotic, and the lamina propria was significantly thickened with mononuclear inflammatory cells (P<0.05). Although MPE significantly affects intestinal microbiota, its consumption at 2% is not recommended for C. carpio due to the lesions made in the liver and intestine.