bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of biopesticides for the control of Erwinia amylovora in apple and pear
Authors: DuPont S. Tianna , Cox Kerik , Johnson Ken , Peter Kari , Smith Tim , Munir Misbakhul , Baro Aina 
Published: May 2023

AbstractWith increasing organic acreage and scrutiny of antibiotics use, alternatives to antibiotics for the control of Erwinia amylovora are of interest to stakeholders. At the same time failures of minimally tested, newly marketed products have resulted in severe infections leading to costly tree and orchard removal. We evaluated antibiotic alternatives in 8 Washington, 3 Oregon, 3 New York and 2 Pennsylvania field experiments conducted 2013 to 2022. Antibiotic alternatives included essential oils (thyme and cinnamon extracts), mineral compounds (potassium aluminum sulfate), oxidizers (peracetic acid-peroxide), soluble coppers (copper octanoate, copper hydroxide, copper sulfate pentahydrate), and biological controls (Aureobasidium pullulans, Bacillus subtilis, bacteriophage). Studies were conducted in ‘Bartlett’ and ‘dAnjou’ pear, ‘Gala’, ‘Cameo,‘ and ‘Red Delicious’ apple with 4 to 6 single-tree replicates arranged in a randomized complete block inoculated with E. amylovora at 80–100% bloom. In summary analysis of 8 Washington trials Alum (potassium aluminum sulfate), Blossom Protect (A. pullulans) and several copper products (Previsto, Mastercop, Instill) provided good disease suppression of 70–73% similar to antibiotic checks. Several essential oil, copper, and peracetic acid-peroxide and biological products (Serenade Opti, Cueva, Oxidate 5.0, Jet Ag, Thyme Guard and Thymox) provided intermediate disease suppression between 45 and 62% significantly better than the water-treated control. In multistate trials Alum with 2–3 applications provided good control in most experiments (means 2019: WA 79%, NY 77%, PA 57%; 2020: OR 86%, NY 65%, WA 28%; 2021: NY 87%, WA 50%). Essential oils with 3–4 applications provided intermediate control NY 2021 81% control 23% thyme oil, 70–85% control NY 2020, 2021 60% cinnamon oil.
Clinical Phenotypes of PCOS: a Cross-Sectional Study
Authors: Elsayed Abdalla Moustafa , Al-Kaabi Latifa Saad , Al-Abdulla Noora Mohammed , Al-Kuwari Moza Salem , Al-Mulla Asmaa Abdulsamad , Al-Shamari Raghad Shaher , Alhusban Ahmed Khaled , AlNajjar Ali Ahmed , Doi Suhail A. R. 
Published: May 2023

AbstractThis cross-sectional study examines the Doi-Alshoumer PCOS clinical phenotype classification in relation to measured clinical and biochemical characteristics of women with polycystic ovary syndrome (PCOS). Two cohorts of women (Kuwait and Rotterdam) diagnosed with PCOS (FAI > 4.5%) were examined. These phenotypes were created using neuroendocrine dysfunction (IRMA LH/FSH ratio > 1 or LH > 6 IU/L) and menstrual cycle status (oligo/amenorrhea) to create three phenotypes: (A) neuroendocrine dysfunction and oligo/amenorrhea, (B) without neuroendocrine dysfunction but with oligo/amenorrhea, and (C) without neuroendocrine dysfunction and with regular cycles. These phenotypes were compared in terms of hormonal, biochemical, and anthropometric measures. The three suggested phenotypes (A, B, and C) were shown to be sufficiently distinct in terms of hormonal, biochemical, and anthropometric measures. Patients who were classified as phenotype A had neuroendocrine dysfunction, excess LH (and LH/FSH ratio), irregular cycles, excess A4, infertility, excess T, highest FAI and E2, and excess 17αOHPG when compared to the other phenotypes. Patients classified as phenotype B had irregular cycles, no neuroendocrine dysfunction, obesity, acanthosis nigricans, and insulin resistance. Lastly, patients classified as phenotype C had regular cycles, acne, hirsutism, excess P4, and the highest P4 to E2 molar ratio. The differences across phenotypes suggested distinct phenotypic expression of this syndrome, and the biochemical and clinical correlates of each phenotype are likely to be useful in the management of women with PCOS. These phenotypic criteria are distinct from criteria used for diagnosis.
Clustering and Analysis of Rural E-commerce Live Broadcast Mode Based on Data Orientation
Authors: Tian Hua 
Published: May 2023

AbstractThe rapid development of network technology has revolutionized information dissemination and made it possible for various new communication channels to gradually seep into people’s daily lives. The primary task within the context of new media is the creation of agricultural products live e-commerce. This study first analyses and categorizes the preferences of product purchasers using a collaborative filtering process in order to achieve this. It then suggests a clustering algorithm based on ROCK that improves the link rather than the previously used distance as a criterion for cluster split and can successfully address the problem of data scarcity based on collaborative suggestion. The difficulties of live e-commerce entrepreneurship and the need of fostering new farmers’ live e-commerce entrepreneurship skills are also discussed in this essay. The case study illustrates that the research’s strategy can successfully examine the path towards developing new farmers’ live e-commerce skills.
Foreign Direct Investment Hosts and Violent Government Repression of Protests
Authors: Adelaiye Samaila Oluwatope 
Published: May 2023

AbstractThere has been a brewing argument on the effects of economic globalization on the repression of human rights. My argument in this article joins the optimistic perspective on the relationship between the globalizing economy and state repression. I argue that governments consider backlash from investors in their decisions about whether to use repression. Investors, motivated by international human rights norms and a fear of violent conflict, would prefer that governments not introduce brute force into a nonviolent protest. Thus, governments in countries that depend more on foreign direct investment (FDI) should be less likely to use violence against protesters than those that are less dependent on FDI. Using data analysis of protest events and inward FDI stock, I test this argument and find a negative relationship between these two variables.
Mapping the distribution of health equity research and practice across a university: a network analysis
Authors: Yousefi Nooraie Reza , Dadgostar Porooshat , Roman Gretchen , Cullen John P. , Bennett Nancy M. 
Published: May 2023

Abstract

Introduction:
Health equity research spans various disciplines, crossing formal organizational and departmental barriers and forming invisible communities. This study aimed to map the nomination network of scholars at the University of Rochester Medical Center who were active in racial and ethnic health equity research, education, and social/administrative activities, to identify the predictors of peer recognition.

Methods:
We conducted a snowball survey of faculty members with experience and/or interest in racial and ethnic health equity, nominating peers with relevant expertise.

Results:
Data from a total of 121 individuals (64% doing research on extent and outcomes of racial/ethnic disparities and racism, 48% research on interventions, 55% education, and 50% social/administrative activities) were gathered in six rounds of survey. The overlap between expertise categories was small with coincidence observed between education and social/administrative activities (kappa: 0.27; p < 0.001). Respondents were more likely to nominate someone if both were involved in research (OR: 3.1), if both were involved in education (OR: 1.7), and if both were affiliated with the same department (OR: 3.7). Being involved in health equity research significantly predicted the centrality of an individual in the nomination network, and the most central actors were involved in multiple expertise categories.

Conclusions:
Compared with equity researchers, those involved in racial equity social/administrative activities were less likely to be recognized by peers as equity experts.
Van Leeuwenhoek – the film: remaking memory in Dutch science cinema 1925–c.1960
Authors: te Hennepe Mieneke 
Published: May 2023

AbstractThis paper examines how the production, content and reception of the film Antony van Leeuwenhoek (1924) influenced the historical framing of science. The film features microcinematography by the pioneering Dutch filmmaker Jan Cornelis Mol (1891–1954), and was part of a dynamic process of commemorating seventeenth-century microscopy and bacteriology through an early instance of visual re-creation – a new way of using scientific material heritage, and of enabling audiences to supposedly observe the world of microscopic organisms in just the same way as the Dutch scientist Antoni van Leeuwenhoek (1632–1723) had observed them for himself. Knowledge transfer concerning material culture, around both historical and contemporary instruments, was the determining factor in the microcinematography practices applied in this film. The production and experience of the film also mirrored the seventeenth-century process of experimentation, playing with optics, and visualizing an entirely new and unknown world. Unlike other biographical science films of the 1920s, Antony van Leeuwenhoek featured abstract depictions of time and movement that allowed the audience to connect the history of science with microcinematography, contributing to the memory of Van Leeuwenhoek's work as the origins of bacteriology in the process.
Demonstrating proof of concept for value-based agreements in Europe: two real-world cases
Authors: Griffiths Elizabeth A. , Odelade Onivefu E. , Gostkorzewicz Joana , Cordero Luis 
Published: May 2023

Abstract

Objectives
Value-based agreements (VBAs) link access, reimbursement, or price to the real-world usage and impact of a medicine, thereby enabling patient access while reducing clinical or financial uncertainty for the payer. VBAs have the potential to support improved patient outcomes, given the value-oriented approach to care, and lead to overall savings, while enabling payers to share risk and reduce uncertainty.

Methods
This commentary outlines the key challenges, enablers, and a framework for successful implementation by comparing the experience of two VBAs for AstraZeneca medicines, aiming to increase confidence in their future use.

Results
Engagement by payers, manufacturers, physicians, and provider institutions, and robust data collection systems that are accessible, simple to use, and add little burden to physicians were key to successfully negotiating a VBA that worked for all stakeholders. In both country systems, a legal/policy framework enabled innovative contracting.

Conclusions
These examples demonstrate proof of concept for VBA implementation in different settings, and may inform future VBAs.
Autophagic activation in porcine oocytes is independent of meiotic progression
Authors: Lee SeungHoon , Jeong Haeyun , Wi Hayeon , No Jin-Gu , Lee Whi-Cheul , Kim Seokho , Yang Hyeon , Byun Sung June , Park Sejin , Kim Jong Gug 
Published: May 2023

SummaryIn this study, we built on our previous research that discovered that autophagy activated the metaphase I stage during porcine oocytes in vitro maturation. We investigated the relationship between autophagy and oocyte maturation. First, we confirmed whether autophagy was activated differently by different media (TCM199 and NCSU-23) during maturation. Then, we investigated whether oocyte maturation affected autophagic activation. In addition, we examined whether the inhibition of autophagy affected the nuclear maturation rate of porcine oocytes. As for the main experiment, we measured LC3-II levels using western blotting after inhibition of nuclear maturation via cAMP treatment in an in vitro culture to clarify whether nuclear maturation affected autophagy. After autophagy inhibition, we also counted matured oocytes by treating them with wortmannin or a E64d and pepstatin A mixture. Both groups, which had different treatment times of cAMP, showed the same levels of LC3-II, while the maturation rates were about four times higher after cAMP 22 h treatment than that of the 42 h treatment group. This indicated that neither cAMP nor nuclear status affected autophagy. Autophagy inhibition during in vitro oocyte maturation with wortmannin treatment reduced oocyte maturation rates by about half, while autophagy inhibition by the E64d and pepstatin A mixture treatment did not significantly affect the oocyte maturation. Therefore, wortmannin itself, or the autophagy induction step, but not the degradation step, is involved in the oocyte maturation of porcine oocytes. Overall, we propose that oocyte maturation does not stand upstream of autophagy activation, but autophagy may exist upstream of oocyte maturation.
Modulatory role of foreign language experience on the Moral Foreign Language Effect
Authors: Privitera Adam John , Li Shaohan , Zhou Yu , Wang Mengqi 
Published: May 2023

AbstractThe Moral Foreign Language Effect (MFLE) is characterized by increased utilitarian decision-making when bilinguals respond to moral dilemmas in their foreign language. While previous research has given us a better understanding of this phenomenon, few studies have investigated how foreign language experience influences the MFLE. The present study investigated whether differences in foreign language proficiency, immersion, or dominance modulated the emergence of the MFLE. Mandarin–English bilingual young adults responded to a series of moral dilemmas in either their native or foreign language. Participants also provided ratings of permissibility and distress after reading each dilemma. We report a dilemma-specific MFLE that was modulated by differences in foreign language experience. Most significant was the observation that separable dimensions of foreign language experience interact when modulating the MFLE in a manner that is dilemma-specific. These findings emphasize the importance of considering differences in foreign language experience across multiple dimensions when investigating the MFLE.
The Unicity, Infinity and Unity of Space
Authors: Onof Christian 
Published: May 2023

AbstractThe article proposes an interpretation of Kant’s notions of form of, and formal intuition of space to explain and justify the claim that representing space as object requires a synthesis. This involves identifying the transcendental conditions of the analytic unity of consciousness of this formal intuition and distinguishing between it and its content. On this reading which builds upon recent proposals, footnote B160–1n. involves no revision of the Transcendental Aesthetic: space is essentially characterized by non-conceptual features. The article also addresses worries about the infinite magnitude and the unicity of space, by considering the characteristics and requirements of geometric constructions.
Theodore Roosevelt and the Unionist Memory of the Civil War: Experience, History, and Politics, 1861–1918
Authors: Wetzel Benjamin J. 
Published: May 2023

AbstractThe meaning of the Civil War, America’s most violent experience, continued to be debated well into the Gilded Age and Progressive Era. The long shadow cast by David Blight’s influential Race and Reunion: The Civil War in American Memory (2001) has meant that debates about the impact and prevalence of reconciliationist rhetoric dominate the literature. This paper adds to a growing body of scholarship that questions the reconciliationist narrative and stresses instead the partisan understanding of the Civil War still prevalent into the twentieth century. In particular, this article uses Theodore Roosevelt’s “memory” of the Civil War to explore the linkages between the Civil War Era and the Age of Empire. It makes two arguments: 1) that in an era when a “reconciliationist” understanding of the Civil War was becoming more prominent, more often than not Roosevelt used his voice as a historian and political figure to assert a “Unionist” interpretation; and 2) that Roosevelt used this memory of the Civil War to advocate for three specific political causes: American empire, the New Nationalism, and American entry into World War I. The paper’s argument and historiographical intervention help scholars of the Gilded Age and Progressive Era to re-imagine the role of Civil War memory in the half century following Appomattox Courthouse.
Seismic Azimuthal Anisotropy of Northeastern Tibetan Plateau From Ambient Noise Double Beamforming Tomography: Implications for Crustal Deformation
Authors: Wu Xiaoyang , Guo Zhen , Li Shilin , Yu Yong , Bai Qipeng , Chen Yongshun John 
Published: May 2023

AbstractIn this study, we obtain a three‐dimensional (3‐D) high resolution seismic anisotropy model of NE Tibet using ambient noise double beamforming (DBF) tomography with ChinArray‐Himalaya II data. DBF tomography technique allows for the simultaneous derivation of local phase velocity and azimuthal anisotropy from ambient noise cross‐correlations without performing tomographic inversion. Based on the DBF tomography results, we have constructed a high resolution 3‐D azimuthal anisotropic shear wave velocity model of NE Tibet. Our model indicates the presence of prominent low velocities and strong azimuthal anisotropy in the mid‐to lower crust beneath the Songpan‐Ganzi belt, while the mid‐to lower crust of the Qilian belt exhibits relatively weak low velocity and azimuthal anisotropy. We propose that crustal channel flow may be the primary mechanism driving crustal deformation in the Songpan‐Ganzi belt, which is in the mature part of the plateau. As the Qilian belt is at an early stage of plateau formation, it is characterized by crustal shortening with the development of a sub‐vertical foliation. Additionally, the misalignment between predicted and observed shear wave splitting reveals decoupled crust and upper mantle deformation west of the Ordos block where eastward mantle flow is deflected by the lithospheric keel of Ordos.
Distinct Seasonality in Aerosol Responses to Emission Control Over Northern China
Authors: Liu Yawen , Wang Minghuai , Yue Man , Qian Yun 
Published: May 2023

AbstractDespite intensive research exploring how aerosols respond to emission control over Northern China, efforts mostly focus on the environmental benefit, especially in winter. Here we found that unlike the most substantial PM2.5 concentration reduction in winter, aerosol optical depth (AOD) declines more than 2 times faster in summer, causing an increase in aerosol radiative effects of 1.2 (5.7)Wm−2 on all‐sky (clear‐sky) conditions over 2013–2019 and largely shaping the climate impact. Low‐level aerosols are shown to be the prime contributor under the synergetic effects of aerosol composition and ambient relative humidity (RH). The dominance of the highly hygroscopic sulfate combined with high RH enables a strong extinction efficiency of the reduced summertime aerosols, while the insignificant AOD decline in wintertime result from the dominance of organic aerosols with weak hygroscopicity, and is further offset by the increased frequencies of extremely high RH. We show the environmental and climatic responses of aerosols to emission control exhibit distinctively different seasonality.
Accelerated TMS - moving quickly into the future of depression treatment
Authors: van Rooij Sanne J. H. , Arulpragasam Amanda R. , McDonald William M. , Philip Noah S. 
Published: May 2023

AbstractAccelerated TMS is an emerging application of Transcranial Magnetic Stimulation (TMS) aimed to reduce treatment length and improve response time. Extant literature generally shows similar efficacy and safety profiles compared to the FDA-cleared protocols for TMS to treat major depressive disorder (MDD), yet accelerated TMS research remains at a very early stage in development. The few applied protocols have not been standardized and vary significantly across a set of core elements. In this review, we consider nine elements that include treatment parameters (i.e., frequency and inter-stimulation interval), cumulative exposure (i.e., number of treatment days, sessions per day, and pulses per session), individualized parameters (i.e., treatment target and dose), and brain state (i.e., context and concurrent treatments). Precisely which of these elements is critical and what parameters are most optimal for the treatment of MDD remains unclear. Other important considerations for accelerated TMS include durability of effect, safety profiles as doses increase over time, the possibility and advantage of individualized functional neuronavigation, use of biological readouts, and accessibility for patients most in need of the treatment. Overall, accelerated TMS appears to hold promise to reduce treatment time and achieve rapid reduction in depressive symptoms, but at this time significant work remains to be done. Rigorous clinical trials combining clinical outcomes and neuroscientific measures such as electroencephalogram, magnetic resonance imaging and e-field modeling are needed to define the future of accelerated TMS for MDD.
Post-diagnostic health behaviour scores and risk of prostate cancer progression and mortality
Authors: Langlais Crystal S. , Graff Rebecca E. , Van Blarigan Erin L. , Neuhaus John M. , Cowan Janet E. , Broering Jeanette M. , Carroll Peter , Kenfield Stacey A. , Chan June M. 
Published: May 2023

Abstract
Background
Individual behaviours are associated with prostate cancer (PC) progression. Behavioural scores, comprised of multiple risk factors, allow assessment of the combined impact of multiple behaviours.

Methods
We examined the association between six a priori scores and risk of PC progression and mortality among 2156 men with PC in the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) cohort: two scores developed based on the PC survivorship literature (‘2021 Score [+ Diet]’); a score developed based on pre-diagnostic PC literature (‘2015 Score’); and three scores based on US recommendations for cancer prevention (‘WCRF/AICR Score’) and survival (‘ACS Score [+ Alcohol]’). Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for progression and PC mortality via parametric survival models (interval censoring) and Cox models, respectively.

Results
Over a median (IQR) of 6.4 (1.3, 13.7) years, we observed 192 progression and 73 PC mortality events. Higher (i.e., healthier) 2021 Score + Diet and WCRF/AICR Scores were inversely associated with risk of PC progression (2021 + Diet: HRcontinuous = 0.76, 95% CI: 0.63–0.90. WCRF/AICR: HRcontinuous = 0.83, 95% CI: 0.67–1.02) and mortality (2021 + Diet: HRcontinuous = 0.65, 95% CI: 0.45–0.93. WCRF/AICR: HRcontinuous = 0.71; 95% CI: 0.57–0.89). The ACS Score + Alcohol was only associated with progression (HRcontinuous = 0.89, 95% CI: 0.81–0.98) while the 2021 Score was only associated with PC mortality (HRcontinuous = 0.62, 95% CI: 0.45–0.85). The 2015 was not associated with PC progression or mortality.

Conclusion
Findings strengthen the evidence that behavioural modifications following a prostate cancer diagnosis may improve clinical outcomes.