bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence des Facteurs Indiciduels et Contextuels Sur la Rehydratation par Voie Orale des Enfants Diarrheiques de Moins de Cinq ans en Côte d’Ivoire
Authors: Boris N’Gran Kuassi , Kone Dr. Hamidou , Owoutou Ondoua 
Published: March 2023

La diarrhée, avec un taux d’incidence de 88,86‰ en 2016, est la troisième cause de la morbidité chez les enfants de moins de 5 ans en Côte d’Ivoire (INS & ICF, 2012). Pour faire face aux maladies diarrhéiques, l’OMS et l’UNICEF recommandent comme mesures curatives la thérapie de réhydratation par voie orale (TRO) composée de la SRO et de la SMR. En dépit du programme de lutte contre les maladies diarrhéiques par la promotion de la thérapie notamment la réhydratation par voie orale, initié depuis 1985 en Côte d’Ivoire, le pourcentage des enfants diarrhéiques ayant reçu une réhydratation par voie orale en 2016 n’était de 56,4%. Il ressort de l’analyse multivariée explicative que la contribution du contexte communautaire dans l’explication de la réhydratation par voie orale des enfants diarrhéiques de moins de 5 ans est estimée à plus 42 %. Les facteurs contextuels associés à la TRO sont : la région de résidence et le milieu de résidence. Quant aux facteurs individuels associés, ce sont : le sexe de l’enfant et le niveau d’instruction de la mère. Ainsi, nous recommandons à l’Etat de Côte d’Ivoire, à travers le Ministère de la santé et de l’hygiène publique d’intensifier les compagnes de lutte contre les maladies diarrhéiques chez l’enfant de moins de cinq ans par la promotion de la thérapie de réhydratation orale (SRO et LMR) auprès de la population du milieu rural surtout dans la région du Nord.
Diarrhea, with an incidence rate of 88.86‰ in 2016, is the third leading cause of morbidity in children under 5 years of age in Côte d'Ivoire (INS & ICF, 2012). To address diarrheal diseases, WHO and UNICEF recommend oral rehydration therapy (ORT) composed of ORS and SMR as curative measures. Despite the program to control diarrheal diseases through the promotion of oral rehydration therapy, initiated since 1985 in Côte d'Ivoire, the percentage of diarrheic children who received oral rehydration therapy in 2016 was only 56.4%. The explanatory multivariate analysis shows that the contribution of the community context in explaining oral rehydration of diarrheic children under 5 years of age is estimated at more than 42%. The contextual factors associated with ORT are: region of residence and environment of residence. The individual factors associated with ORT are: the child's sex and the mother's level of education. Thus, we recommend that the State of Côte d'Ivoire, through the Ministry of Health and Public Hygiene, intensify the campaigns against diarrheal diseases in children under five years of age by promoting oral rehydration therapy (ORT and MRL) among the rural population, especially in the northern region.
Construct of The Environmental Education on The Quranic Paradigm: a Literature Review
Authors: Siswanto  
Published: March 2023

The rise of environment crisis are caused by human activities. The effect of destructive behavior, threat of human life substainabilities is felt. The center of enviroment problems philosophically is lack of relation equilibrium between human being and enviroment. This research focused on environmental education concept, Qur'anic view of environment, and environment education construct of Qur'an paradigm. The kind of this research is library one. The data collection is documentation technique. The results of this research are environmental education is an effort to change behavior and attitude made by various parties or elements of society that aims to increase knowledge, skill and communities’ awareness of environmental values that ultimately can drive environmental safety for the benefit of future generation. The Qur'an becomes moral code governing human relationship with their environment. environment structure becomes human’s responsibility as God's servant on earth. The Qur'an very firmly says that the main role of human is as sevant ('abd Allâh) whose their primary mission is serving his Lord as well as the manager (khalîfah) who are able to utilize and prosper this universe. The environment education based the Quranic paradigm is directed to programme and education activities that aim at consiousness and wisdom to environment based on the Quranic values. The environmental education motivate the students to belong to the Quranic character in protecting the environment from damages and quarenting its conservation.
Counterradicalism Through Religious Education Curriculum: Solution to The Religious Literacy Crisis in Indonesian Islamic Universities
Authors: Sapdi Rohmat Mulyana , Ali Nur 
Published: March 2023

Islamic universities have been accused of being the milieu of the growing movement of radicalism along with the new facts about the involvement of two state Islamic universities among 10 state universities involved in radicalism. The campus management has responded to the movement by developing a religious curriculum and interreligious-based learning to improve religious literacy competence. This paper aims to evaluative the practice of religious curriculum and literacy as a strategy in improving counterradicalism in campus. The interviews, observations, and data analysis resulted in the finding that the religious curriculum development with open minded principles, religious universality, local wisdom, and humanism values in the learning activities in either classroom and or places of worship of other religions can foster good counterradicalism and interfaith literacy and eliminate the evolution of radical attitudes among students. This paper suggested that the learning of religious education in campuses and schools include observation to the areas of interreligious activities and religious literacy studies to improve students' understanding of religious values among religious communities, so tolerance and counterradicalism can be fostered.
Analisis Spektroskopi Air Kelapa dan Biji Chia sebagai Minuman Kesehatan
Authors: Alwi Muhammad , Helilusiatingsih Nunuk , Qumillaila Qumillaila , Annisa Ayu 
Published: March 2023

Minuman yang bagus kesehatan adalah air putih atau air yang mengandung senyawa bioaktif dan zat gizi seperti mineral dan lainnya. Air kelapa yang masih muda sangat disukai oleh masyarakat karena rasanya segar dan memiliki zat aktif yang berguna untuk menangkal racun dan menambah nilai gizi yang alami baik untuk tubuh kita dan bagi olahragawan. Perlu dilakukan penelitian inovasi minuman kesehatan dari campuran air kelapa dan biji chia untuk memeroleh khasiat yang baik bagi tubuh saat dan setelah beraktivitas olahraga dan lainnya. Tujuan penelitian ini adalah untuk mengetahui potensi campuran air kelapa dan biji chia sebagai minuman olahraga. Metode penelitian yang dilakukan adalah preparasi minuman dari air kelapa dan biji chia, kemudian dilakukan analisa spektroskopi AAS untuk mengetahui kadar mineral Na, K, Ca, dan Mg. Selanjutnya dilakukan analisa spektroskopi FTIR untuk mengetahui kandungan senyawa antioksidan. Untuk mengetahui aktivitas atioksidan dilakukan dengan metode DPPH dan spektroskopi Uv-Vis. Hasil penelitian menunjukkan bahwa kandungan Na pada tiap sampel berturut-turut AKC 1 : 635,66 mg/kg, AKC 2 638,79 mg/kg, AKC 3 : 639,21 mg/kg, AKC 4 : 639, 98 mg/kg. Kandungan K pada tiap sampel berturut-turut K berturut-turut AKC 1 : 242,93 mg/kg, AKC 2 : 244,57 mg/kg, AKC 3 : 245,72 mg/kg, AKC 4 : 246,02 mg/kg. kandungan Ca pada tiap sampel berturut-turut AKC 1 : 550,18 mg/kg, AKC 2 : 556,49 mg/kg, AKC 3 : 555,26 mg/kg, AKC 4 : 556,78 mg/kg. kandungan Mg berturut-turut AKC 1 : 30,55 mg/kg, AKC 2 : 31,67 mg.kg, AKC 3 : 31,92 mg/kg, AKC 4 : 32,01 mg/kg. Hasil spektroskopi FTIR menunjukkan tiap sampel mengandung senyawa antioksidan kampferol, myrisetin, quercetin, asam sinamat, dan asam kafeat. Hasil uji aktivitas antioksidan menunjukkan bahwa aktivitas antioksidan masing-masing sampel termasuk kuat dengan IC50 berturut-turut AKC 1 : 62,98 ppm, AKC 2 : 63,19 ppm, AKC 3 : 65,02 ppm, AKC 4 : 65,85 ppm. Kesimpulan dari penelitian ini adalah dari hasil spektroskopi menunjukkan campuran air kelapa dan biji chia memiliki kandungan yang bermanfaat bagi tubuh. Campuran air kelapa dan biji chia berpotensi sebagai minuman kesehatan dengan formula terbaik adalah AKC 4 dengan formula air kelapa dan biji chia 200 ml : 10 gram.
Efficacy of a Modified Cocktail for Periarticular Local Infiltration Analgesia in Total Knee Arthroplasty
Authors: Wang Qiuru , Zhao Chengcheng , Hu Jian , Ma Ting , Yang Jing , Kang Pengde 
Published: March 2023

Background:
Periarticular local infiltration analgesia (LIA) is largely utilized for controlling pain after total knee arthroplasty (TKA). The present work aimed to assess the efficacy of a modified LIA cocktail for patients undergoing TKA.

Methods:
Magnesium sulfate (MgSO4) and sodium bicarbonate (NaHCO3) were added to a conventional LIA cocktail comprising ropivacaine, epinephrine, and dexamethasone. After the safety of this modified cocktail was tested in rats, its efficacy and safety were evaluated in a prospective, double-blinded study including 100 individuals randomized to receive periarticular infiltration of the modified cocktail or a conventional cocktail. The primary outcome was postsurgical use of morphine hydrochloride for rescue analgesia. Secondary outcomes were the time until the first rescue analgesia, postsurgical pain (on a visual analog scale [VAS]), functional recovery (assessed by range of knee motion and ambulation distance), time to discharge, and complication rates.

Results:
Adding NaHCO3 to the local anesthetics caused some instantaneous precipitation in all cases. Administering the modified cocktail to rats did not obviously damage the injected area of the nerve or surrounding tissues. Administration of the modified cocktail to patients was associated with markedly reduced postsurgical morphine use in the initial 24 hours (4.2 ± 5.0 versus 14.6 ± 8.9 mg, p < 0.001), reduced total morphine use (9.8 ± 8.4 versus 19.6 ± 11.4 mg, p < 0.001), prolonged time to the first rescue analgesia, lower VAS pain scores at rest and during motion at 12 and 24 hours following the operation, better functional recovery on postoperative days 1 and 2, and a shorter hospital stay. The modified and conventional cocktail groups had similar rates of complications.

Conclusions:
The present modification of a conventional cocktail significantly prolonged analgesia and reduced opioid consumption, which may substantially improve pain control in arthroplasty.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
A Pilot Demonstration of Flaring Gas Recovery during Shale Gas Well Completion in Sichuan, China
Authors: Xue Ming , Li Xingchun , Cui Xiangyu , Cheng Xin , Liu Shuangxing , Xu Wenjia , Wang Yilin 
Published: March 2023

SummaryAs one of the largest emitters in the world, the oil and gas industry needs to apply more effort to greenhouse gas (GHG) reduction. Methane, as a potent GHG, could largely determine whether natural gas could serve as a bridging energy toward a sustainable future. In the past decade, oil and gas companies in China have significantly enhanced casing gas recovery and reduced large volume flaring (&gt;2×104 m3/d). However, the remaining low- to mid-volume flaring gas was left for further recovery. Shale gas production in China has met a surge in the number of drilling wells. Those new wells were characterized by a relatively low gas production rate (&lt;1×106 m3/d) in comparison with shale gas wells in the US. As a result, flaring gas during well completion needs to be recycled or used to enhance the gas recovery rate. In this study, we carried out a pilot demonstration project of flaring gas recovery to reduce GHG emissions in the Weiyuan shale gas region in Sichuan Province, China. We adopted the technical route of dehydration and natural gas compression. The recycled natural gas was transformed into compressed natural gas (CNG) and transported to the nearest CNG station for further use. The inlet gas pressure was between 2.85 and 5.82 MPa, and the outlet pressure was kept stable at around 20 MPa to meet the standard of CNG. The manufactured device also showed sound flexibility with the recovery rate between 523.22 and 1224.38 m3/h, which was 28–157% of the designed capacity. The combination of the molecular sieve with high capacity, post low-pressure dehydration, and the application of hydraulic piston in the compression system have guaranteed the equipment to meet the designed performance. The equipment applied in the pilot demonstration has well matched with the local transportation, gas composition, and surface engineering of the well completion. It has the potential of popularization and application in the shale gas tight gas regions in China. Other technical routes, such as small-scale gas to chemicals or natural gas hydrate, should be considered for industrial application for gas flowing rate less than 2×104 m3/d to ensure a further drive down of methane emission along the value chain.
Safety and efficacy of perioperative FLOT regimen in Japanese patients with gastric, esophagogastric junction, or esophageal adenocarcinoma: A single-institution experience
Authors: Takei Shogo , Kawazoe Akihito , Komatsu Masaru , Sato Kazuma , Mishima Saori , Kotani Daisuke , Akimoto Eigo , Yura Masahiro , Sakamoto Naoya , Sakashita Shingo , Kuwata Takeshi , Kojima Takashi , Fujita Takeo , Kinoshita Takahiro , Shitara Kohei 
Published: March 2023

Abstract
Background
Although the common treatment strategy for localized gastric cancer in Japan is gastrectomy followed by adjuvant chemotherapy, several randomized studies in non-Japanese populations have established perioperative chemotherapy as the standard treatment for localized gastric or gastroesophageal junction adenocarcinoma. Therefore, we have implemented this strategy in our institution.
Methods
We retrospectively reviewed the medical records of patients with resectable gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma who had received perioperative FLOT from February 2020 to November 2021.
Results
In this study, a total of 48 patients were analyzed, with a median age of 70 years (range: 29–82). At the time of diagnosis, 46 patients (95.8%) had T3 or higher-grade primary lesions, and 43 (90%) had lymph node metastasis. Seven patients had resection before completing four cycles of preoperative chemotherapy, and 37 of 48 (77.1%) completed four cycles with 35 of these receiving radical resection. Among the 42 patients who had radical resection after FLOT, 41 (97.6%) achieved R0 resection, including 4 (9.5%) with a pathological complete response. After resection, 29 patients (60.4%) received at least one cycle of postoperative FLOT, and 20 (41.7%) completed eight cycles of FLOT treatment. Chemotherapy-related adverse events of Grade 3 or higher occurred during the pre- and postoperative FLOT in 41 patients (85.4%), including leukopenia (52.1%), neutropenia (83.3%), febrile neutropenia (8.3%), and anorexia (10.4%). No treatment-related deaths occurred.
Conclusions
These findings were comparable to those in the pivotal FLOT 4 study, suggesting acceptable feasibility of the FLOT regimen in Japanese clinical practice.
Template-based genome editing directed by the SviCas3
Authors: Tong Wang-Yu , Yu Zhong-Fan , Li Yong , Ye Shou-Dong , Yong De-Xiang , Wang An-Jing , Tang Yan-Yan , Xu Xin , Qiu Cai-Hua , Yang Xing-Wang , Xia Ting-Ting , Li Mei-Li , Liu Qing-Yang , Zhu Si-Qi , Zhang Yan , Cao Su-Li , Sun Yan , Li Xue 
Published: March 2023

Abstract
RNA-guided genome editing based on the CRISPR-Cas system is currently the most effective genome editing technique. Here, we report that SviCas3 from the subtype I-B-Svi Cas system in Streptomyces virginiae IBL14 is an RNA-guided and DNA-guided DNA endonuclease suitable for the gene and/or base editing of prokaryotic and eukaryotic cell genomes. The genome editing efficiency of SviCas3 guided by DNA was no less than that of SviCas3 guided by RNA. It should be noted that no off-target effects or indel-formation were detected in targeted sequencing. In particular, t-DNA, as a template and a guide, does not require a proto-spacer-adjacent motif, demonstrating that CRISPR, as the basis for crRNA design, is not required for SviCas3-mediated gene and base editing. This discovery will provide important tools for the creation and modification of living things and the treatment of human genetic diseases, and will usher in a new era of DNA-guided genome editing.
A computational model of epidemic process with three variants on a synthesized human interaction network
Authors: seprianus seprianus , Nuraini Nuning , Saputro Suhadi Wido 
Published: March 2023

Abstract
Virus mutations give rise to new variants that cause multiple waves of pandemics and escalate the infected number of individuals. The spread of virus variants on a network could reflect how the disease continues to spread in a human population for a long time and becomes a pandemic. In this paper, we develop a mathematical model by paying attention to the microscopic process of disease spreading in a human interaction network by adding variants in the middle of spreading. We also generate a synthesized human interaction network with a certain structure such as the average number of degrees and the frequency of contacts to describe human interaction in a population. Then, we randomly choose a small number of individuals infected by the original virus at the initial condition and add a small number of individuals infected by other variants after a certain time lag. Unlike the SIR classic models, we do not use a recovery rate in this study. Instead, we use the time when an individual is infected for the first time and the infection period to move an infected individual to a recovered state. Then, we will show several different examples of synthesized human interaction networks to describe how the structures determine epidemic dynamics.
Full-length transcriptomics study of Ustiloxins-induced hepatocyte injury
Authors: Zhang Guomei , Zhou Xuming , Li Han , Liu Shanshan , Sun Lihua 
Published: March 2023

Abstract
Background: Ustiloxins is a mycotoxin produced by the metabolism of Rice false smut. Studies have shown that Ustiloxins may be toxic to animals, but there is still a lack of toxicological evidence. The liver, as the main organ for the biotransformation of foreign chemicals, may be the direct target organ of Ustiloxins toxicity.
Results: In this study, we found that Ustiloxins inhibited BNL CL.2 cells in a dose-and time-dependent manner. In addition, scanning electron microscope observation showed that the cell membrane of the experimental group was damaged, with the appearance of apoptotic bodies. We analyzed the key action targets of Ustiloxins on hepatocyte injury using full-length transcriptomics. A total of 1099 differentially expressed genes were screened, of which 473 genes were up-regulated, and 626 genes were down-regulated. The selected genes were verified using qRT-PCR, and the results were consistent with those of full-length transcriptomics, proving the reliability of full-length transcriptomics. Besides, we also found that the expression of MCM7 and CDC45 in BNL CL.2 cells treated with Ustiloxins decreased, and the expression of CCl-2, CYP1b1, CYP4f13, and GSTM1 increased according to qRT-PCR. Moreover, the ROS and GSH levels were significantly increased in cells exposed to 5, 10, and 20 μg/mL of Ustiloxins.
Conclusions: Ustiloxins could change CYP450 and GST-related genes, affect DNA replication and cell cycle, and lead to obvious oxidative stress and liver cell injury.
Chinese Abdominal tuina on metabolic sydrome patients with heat stagnation of liver and stomach sydrome: study protocol for a randomized parallel controlled trial
Authors: Mao Xinxin , Shi Shuqing , Wang Yajiao , Gao Xiya , Zhao Lu , Wu Huaqin , Song Qingqiao , Zhang Bingxuan 
Published: March 2023

Abstract
Introduction The incidence of Metabolic Syndrome (MetS) continues to rise and has become a serious health hazard worldwide. Abdominal tuina treatment for MetS has the advantages of high safety and strong patient compliance, but there is still a lack of high-quality evidence-based medicine evidence.While,the study of the pathogenesis of MetS has progressed slowly, and its initiating factors are still unknown, so it is crucial to explore its mechanisms.
Methods and analysis This study was a randomized parallel controlled trial. One hundred and forty-four patients with metabolic sydrome patients with heat stagnation of liver and stomach sydrome were included, and the patients were randomly divided into a experimental group and a control group in a 1:1 ratio according to the random assignment principle, and the treatment course was 4 weeks in both groups. The control group was treated with conventional basic treatment based on lifestyle intervention; the experimental group was treated with abdominal massage (fifteen minutes) and acupoint pressure (thirty seconds/acupoint) on basis of the control group, 3 times/week, 12 times in total. Indicators were collected at different time points of the study, the results were analyzed and the safety was evaluated. Follow-up visits were performed 30 days after the end of the trial to assess the subjects' condition. The aim of this study was to evaluate the efficay and safety of abdominal tuina on the the early metabolic syndrome(MetS) patients with liver and stomach heat rentention type, and to provide new method and high quality evidence-based medical evidence for the prevention and treatment MetS.And to preliminary explore the action targets of abdominal tuina to improve MetS, provide theoretical basis for further mechanism exploration and direction for enriching the connotation of tuina theory.
Trial registration ClinicalTrials.gov, ChiCTR2200057997, Registered on 26 March 2022.
Analysis of the potential biological mechanisms of diosmin against renal fibrosis based on network pharmacology and molecular docking approach
Authors: Zhao Wen-Man , Wang Zhi-Juan , Shi Rui , Zhu Yvyv , Li Xun-Liang , Wang De-Guang 
Published: March 2023

AbstractBackgroundInterstitial fibrosis is involved in the progression of various chronic kidney diseases and renal failure. Diosmin is a naturally occurring flavonoid glycoside that has antioxidant, anti-inflammatory, and antifibrotic activities. However, whether diosmin protects kidneys by inhibiting renal fibrosis is unknown.MethodsThe molecular formula of diosmin was obtained, targets related to diosmin and renal fibrosis were screened, and interactions among overlapping genes were analyzed. Overlapping genes wereused for gene function and KEGG pathway enrichment analysis.TGF-β1 was used to induce fibrosis in HK-2 cells, and diosmin treatment was administered. The expression levels of relevant mRNA were then detected.ResultsNetwork analysis identified 295 potential target genes for diosmin, 6828 for renal fibrosis, and 150 hub genes. Protein–protein interaction network results showed that CASP3, SRC, ANXA5, MMP9, HSP90AA1, IGF1, RHOA, ESR1, EGFR, and CDC42 were identified as key therapeutic targets. GO analysis revealed that these key targets may be involved in the negative regulation of apoptosis and protein phosphorylation. KEGG indicated that pathways in cancer, MAPK signaling pathway, Ras signaling pathway, PI3K-Akt signaling pathway, andHIF-1 signaling pathway were key pathways for renal fibrosis treatment. Molecular docking results showed that CASP3, ANXA5, MMP9, and HSP90AA1 stably bind to diosmin. Diosmin treatment inhibited the protein and mRNA levels of CASP3, MMP9, ANXA5, and HSP90AA1.Network pharmacology analysis and experimental results suggest that diosmin ameliorates renal fibrosis by decreasing the expression of CASP3, ANXA5, MMP9, and HSP90AA1.ConclusionsDiosmin has a potential multi-component, multi-target, and multi-pathway molecular mechanism of action in the treatment of renal fibrosis. CASP3, MMP9, ANXA5, and HSP90AA1 might be the most important direct targets of diosmin.