bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating serum metabolites as biomarkers and predictors of residual feed intake in lactating dairy cows
Authors: Hailemariam Dagnachew , Manafiazar Ghader , Baes Christine , Schenkel Flavio , Miglior Filippo , Stothard Paul , Plastow Graham 
Published: January 2025

AbstractThis study explored the potential of circulatory serum metabolite profiles to increase understanding of the physiology of feed efficiency and identify biomarkers to predict residual feed intake (RFI) in lactating Holsteins. Serum metabolite profiles were compared in high (n = 20) and low RFI (n = 20) cows at early, mid, and late lactation stages. The low RFI cows had decreased (P < 0.05) concentrations of dodecanoylcarnitine, dodecenoylcarnitine, dodecanedioylcarnitine, tetradecanoylcarnitine, succinic acid, trimethylamine N-oxide, betaine, and increased concentrations of p-Hydroxyhippuric acid, hydroxysphingomyeline C16:1, phosphatidylcholine diacyl C40:6, and glutarylcarnitine at early lactation. A similar comparison at mid lactation stage showed altered serum concentrations of 26 metabolites that fall into the categories of acyl carnitines, glycerophospholipids, biogenic amines, amino acids, and organic acids. At late lactation, fewer sets of metabolites were significantly affected by RFI grouping. Receiver operator curve analyses identified p-Hydroxyhippuric acid as the top biomarker at early lactation and acetylornithine at mid and late lactation. Models based on sets of serum metabolites in early, mid, and late lactation stages predicted RFI with a validation coefficient of determination of 0.54, 0.68, and 0.64, respectively. This study demonstrated the potential of circulatory serum metabolites as biomarkers and predictors of RFI in lactating dairy cows.
Research on vehicle scheduling for forest fires in the northern Greater Khingan Mountains
Authors: Zhang Jie , He Junnan , Ren Shihao , Zhou Pei , Guo Jun , Song Mingyue 
Published: January 2025

AbstractIn the face of forest fire emergencies, fast and efficient dispatching of rescue vehicles is an important means of mitigating the damage caused by forest fires, and is an effective method of avoiding secondary damage caused by forest fires, minimizing the damage caused by forest fires to the ecosystem, and mitigating the losses caused by economic development. this paper takes the actual problem as the starting point, constructs a reasonable mathematical model of the problem, for the special characteristics of the emergency rescue vehicle scheduling problem of forest fires, taking into account the actual road conditions in the northern pristine forest area, through the analysis of the cost of paths between the forest area and the highway, to obtain the least obstructed rescue paths, to narrow the gap between the theoretical model and the problem of the actual. Improvement of ordinary genetic algorithm, design of double population strategy selection operation, the introduction of chaotic search initialization population, to improve the algorithm’s solution efficiency and accuracy, through the northern pristine forest area of Daxing’anling real forest fire cases and generation of large-scale random fire point simulation experimental test to verify the effectiveness of the algorithm, to ensure that the effectiveness and reasonableness of the solution to the problem of forest fire emergency rescue vehicle scheduling program. It enriches the solution method of forest fire emergency rescue vehicle dispatching problem in Great Khingan area, which is of great significance to improve the emergency rescue capability in case of sudden forest fire. Through simulation experiments, the proposed Improved Genetic Algorithm (IGA) achieved an average rescue time reduction of 8.5% compared to conventional Genetic Algorithm (GA) and 3.5% compared to Improved Artificial Bee Colony (IABC) algorithm, with an average solution time of 9.4 ms.
Selenium nanoparticles modified niobium MXene for non-enzymatic detection of glucose
Authors: E. Prabisha K. , K. Neena P. , Ankitha Menon , Rasheed P. Abdul , Suneesh P. V. , Satheesh Babu T. G. 
Published: January 2025

AbstractGlucose sensing remains a crucial need as diabetes is a worldwide concern. This work reports the application of Nb2CTx—selenium nanoparticle composite material for the nonenzymatic sensing of glucose. The surface morphology of the synthesized composite was analyzed using various microscopic techniques like scanning electron microscopy, transmission electron microscopy, and its structural properties were analyzed using diffraction and spectroscopic methods. A gold disc electrode was modified using the nanocomposite and tested for glucose in an alkaline medium. The sensing was based on the oxidation of glucose on the catalytic surface. The glucose was quantified amperometrically at a significantly lower overpotential of 0.16 V. The sensor showed a good detection range from 2 to 30 mM with a sensitivity of 4.15 µA mM−1 cm−2 and a detection limit of 1.1 mM.
Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory
Authors: Charles James Jeyanthan , Schulze Hannah , Siems Nadine , Prehn Christian , Quast Daniel R. , Trampe Nadine , Gold Ralf , Faissner Simon 
Published: January 2025

AbstractA substantial proportion of patients suffer from Post-COVID Syndrome (PCS) with fatigue and impairment of memory and concentration being the most important symptoms. We here set out to perform in-depth neuropsychological assessment of PCS patients referred to the Neurologic PCS clinic compared to patients without sequelae after COVID-19 (non-PCS) and healthy controls (HC) to decipher the most prevalent cognitive deficits. We included n = 60 PCS patients with neurologic symptoms, n = 15 non-PCS patients and n = 15 healthy controls. Basic socioeconomic data and subjective complaints were recorded. This was followed by a detailed neuropsychological test battery, including assessments of general orientation, motor and cognitive fatigue, screening of depressive and anxiety symptoms, information processing speed, concentration, visuomotor processing speed, attention, verbal short-term and working memory, cognitive flexibility, semantic and phonematic word fluency, as well as verbal and visual memory functions. Neurologic PCS patients had more complaints with significantly higher fatigue scores as well as higher levels of depressive and anxiety symptoms compared to Non-PCS and HC. Deep neuropsychological assessment showed that neurologic PCS patients performed worse in a general screening of cognitive deficits compared to HC. Neurologic PCS patients showed impaired mental flexibility as an executive subfunction, verbal short-term memory, working memory and general reactivity (prolonged reaction time). Multiple regression showed fatigue affected processing speed; depression did not. Self-reported cognitive deficits of patients with neurologic PCS including fatigue, concentration, and memory deficits, are well mirrored in impaired performance of cognitive domains of concentration and working memory. The present results should be considered to optimize treatment algorithms for therapy and rehabilitation programs of PCS patients with neurologic symptoms.
Whole examination AI estimation of fetal biometrics from 20-week ultrasound scans
Authors: Venturini Lorenzo , Budd Samuel , Farruggia Alfonso , Wright Robert , Matthew Jacqueline , Day Thomas G. , Kainz Bernhard , Razavi Reza , Hajnal Jo V. 
Published: January 2025

AbstractThe current approach to fetal anomaly screening is based on biometric measurements derived from individually selected ultrasound images. In this paper, we introduce a paradigm shift that attains human-level performance in biometric measurement by aggregating automatically extracted biometrics from every frame across an entire scan, with no need for operator intervention. We use a neural network to classify each frame of an ultrasound video recording. We then measure fetal biometrics in every frame where appropriate anatomy is visible. We use a Bayesian method to estimate the true value of each biometric from a large number of measurements and probabilistically reject outliers. We performed a retrospective experiment on 1457 recordings (comprising 48 million frames) of 20-week ultrasound scans, estimated fetal biometrics in those scans and compared our estimates to real-time manual measurements. Our method achieves human-level performance in estimating fetal biometrics and estimates well-calibrated credible intervals for the true biometric value.
Improving 3D deep learning segmentation with biophysically motivated cell synthesis
Authors: Bruch Roman , Vitacolonna Mario , Nürnberg Elina , Sauer Simeon , Rudolf Rüdiger , Reischl Markus 
Published: January 2025

AbstractBiomedical research increasingly relies on three-dimensional (3D) cell culture models and artificial-intelligence-based analysis can potentially facilitate a detailed and accurate feature extraction on a single-cell level. However, this requires for a precise segmentation of 3D cell datasets, which in turn demands high-quality ground truth for training. Manual annotation, the gold standard for ground truth data, is too time-consuming and thus not feasible for the generation of large 3D training datasets. To address this, we present a framework for generating 3D training data, which integrates biophysical modeling for realistic cell shape and alignment. Our approach allows the in silico generation of coherent membrane and nuclei signals, that enable the training of segmentation models utilizing both channels for improved performance. Furthermore, we present a generative adversarial network (GAN) training scheme that generates not only image data but also matching labels. Quantitative evaluation shows superior performance of biophysical motivated synthetic training data, even outperforming manual annotation and pretrained models. This underscores the potential of incorporating biophysical modeling for enhancing synthetic training data quality.
Amplification-free detection of Mycobacterium tuberculosis using CRISPR-Cas12a and graphene field-effect transistors
Authors: Wang Weiqi , Du Huanyu , Dai Changhao , Ma Hongwenjie , Luo Shi , Wang Xuejun , Guo Mingquan , Kong Derong , Wei Dacheng 
Published: January 2025

In this work, we present a graphene field-effect transistor integrated with the CRISPR/Cas12a system for the ultrasensitive detection of Mycobacterium tuberculosis, achieving a detection limit of 2.42 × 10−18 M within 5 minutes.
Instantaneous asymmetry of the Martian bow shock: A single- and dual-spacecraft study using MAVEN and Mars Express
Authors: Nesbit-Östman Sara , Gunell Herbert , Goetz Charlotte 
Published: January 2025

Aims. We study the instantaneous asymmetry of the Martian bow shock during a change in the direction of the interplanetary magnetic field (IMF) and for steady-state conditions. Specifically, we study the asymmetry with regard to the convective electric field and to the crustal fields of Mars.
Methods. Two methods were used: First, a single-spacecraft method in which a switch in hemisphere in the Mars solar-electric (MSE) coordinate system was studied during a change in the direction of the interplanetary magnetic field. Second, we used a dual-spacecraft method wherein near simultaneous bow shock crossings on opposite hemispheres were studied. The dual bow shock crossings were then compared to a bow shock model, and the difference in the distance to the model was used as a measure of asymmetry.
Results. With the single-spacecraft method, an asymmetry with respect to the solar wind convective electric field, Esw, was found, wherein the bow shock was farther from the planet in the ZMSE <0 hemisphere, that is, the −E hemisphere. With the dual-spacecraft method, the mean of the magnitude of the asymmetries in the individual case was 0.13 RM. However, the standard deviation was as high as the mean, and no significant asymmetry could be attributed either to the solar wind convective electric field or to the Martian crustal fields. A strong asymmetry without a clear correlation to these factors was found nonetheless. Possible causes of the measured asymmetry are discussed.
Conclusions. The magnitude of the asymmetries in individual observations is larger than the average asymmetries. This indicates that the shape of the Martian bow shock is dynamic and influenced by fluctuations or wave phenomena.
Endoscopic size measurement of colorectal polyps: a systematic review of techniques
Authors: Taghiakbari Mahsa , Djinbachian Roupen , Labelle Juliette , von Renteln Daniel 
Published: January 2025

AbstractAccurate size measurement of colorectal polyps is critical for clinical decision making and patient management. This systematic review aimed to evaluate the current techniques used for colonic polyp measurement to improve the reliability of size estimations in routine practice.A comprehensive literature search was conducted across PubMed, EMBASE, and MEDLINE to identify studies relevant to size measurement techniques published between 1980 and March 2024. The primary outcome was the accuracy of polyp sizing techniques used during colonoscopy.61 studies were included with 34 focusing on unassisted and assisted endoscopic visual estimation and 27 on computer-based tools. There was significant variability in visual size estimation among endoscopists. The most accurate techniques identified were computer-based systems, such as virtual scale endoscopes (VSE) and artificial intelligence (AI)-based systems. The least accurate techniques were visual or snare-based polyp size estimation. VSE assists endoscopists by providing an adaptive scale for real-time, direct, in vivo polyp measurements, while AI systems offer size measurements independent of the endoscopist’s subjective judgment.This review highlights the need for standardized, accurate, and accessible techniques to optimize sizing accuracy during endoscopic procedures. There is no consensus on a gold standard for measuring polyps during colonoscopy. While biopsy forceps, snare, and graduated devices can improve the accuracy of visual size estimation, their clinical implementation is limited by practical, time, and cost challenges. Computer-based techniques will likely offer improved accuracy of polyp sizing in the near future.
Cobalt-Catalyzed Regioselective Hydroformylation of Allylic Alcohol Esters
Authors: Lu Wenxin , Chong Qinglei , Meng Fanke , Du Zhenhao 
Published: January 2025

AbstractAliphatic aldehydes are important building blocks in organic synthesis due to their high reactivity and versatility. Herein, we report a simple, mild and efficient method for the hydroformylation of allyl alcohol esters under cobalt catalysis. This procedure offers good functional group tolerance, moderate to good product yields and exclusive chemo- and regioselectivity, making it an attractive method to prepare aldehydes with linear selectivity.
Doyle–Kirmse Reaction of S-Allyl and S-Propargyl Phosphorothioates
Authors: Tual Laurine , Rognan Charlou , Maujean Timothé , Gulea Mihaela , Pertschi Romain , Girard Nicolas , Blond Gaëlle 
Published: January 2025

AbstractThe Doyle–Kirmse reaction represents a powerful synthetic tool for forming both C–S and C–C bonds in a single process. The rhodium-catalyzed Doyle–Kirmse reaction of S-allyl and S-propargyl phosphorothioates with diazoesters has been developed and represents a rare example involving substrates bearing an electron-withdrawing group on the sulfur atom. The transformation takes place at room temperature, in only 5 minutes, and leads via a [2,3]-sigmatropic rearrangement of the sulfonium ylide intermediate to the corresponding S-homoallyl or S-homoallenyl phosphorothioates in yields ranging from 25% to 92% (19 examples).
Recyclable Copper-Catalyzed Cascade Coupling/Condensation/ Deacylation Reaction of 2′-Halotrifluoroacetanilides with β-Keto Esters toward 2-(Trifluoromethyl)indoles
Authors: Cai Mingzhong , Wang Yan , Ye Qian 
Published: January 2025

AbstractAn efficient heterogeneous copper-catalyzed cascade coupling/condensation/deacylation reaction of 2′-halotrifluoroacetanilides with β-keto esters has been developed. The reaction proceeds smoothly in anhydrous dimethyl sulfoxide at 80–90 °C using Cs2CO3 as base and 10–20 mol% SBA-15-immobilized l-proline–CuI complex [SBA-15–l-Proline–CuI] as catalyst and provides a general and practical method for the assembly of a variety of polysubstituted 2-(trifluoromethyl)indoles in good to high yields. This heterogenized copper catalyst can be easily recovered via a simple centrifugation process and reused more than seven cycles with almost consistent catalytic activity.
Impact of Vitamin D3 Deficiency on Quality of Life in Epilepsy: A Call for Routine Screening and Intervention
Authors: Sulena Sulena , Parkash Ishaan , Bansal Pir Dutt , Nagar Akanksha , Gupta Dipti , Bahetra Mamta 
Published: January 2025

Abstract
Background The association between vitamin D3 levels and quality of life (QoL) in people with epilepsy on long-term antiseizure medications is an area of ongoing research. This study aims to assess serum vitamin D3 levels in people with epilepsy and evaluate the effects of supplementation on their QoL.
Methods A prospective study was conducted at a tertiary hospital from June 2021 to July 2022. People with epilepsy aged 12 to 45 years, receiving antiseizure medications for at least 1 year, were recruited. Baseline serum vitamin D3 levels were measured, and epilepsy diagnoses were confirmed according to the International League Against Epilepsy guidelines (2017). QoL was evaluated using the Quality of Life in Epilepsy Scale (QOLIE-31) for adults and the Quality of Life in Epilepsy for Adolescents Scale (QOLIE-48) for adolescents. Patients with vitamin D3 deficiencies received supplementation, and their QoL were reassessed at 3 and 6 months. Data were analyzed using t-tests, multiple logistic regression, and analysis of variance.
Results At baseline, the mean serum vitamin D3 level was 17.99 ± 6.77 ng/mL, increasing to 21.46 ± 2.91 ng/mL at 3 months and 24.41 ± 3.19 ng/mL at 6 months. Patients with vitamin D3 deficiency exhibited significantly lower scores across multiple domains of the Quality of Life Inventory (QOLIE-31 and QOLIE-48). A significant improvement was seen in most of the QOLIE scores and serum vitamin D3 levels after vitamin D3 supplementation.
Conclusion People with epilepsy on long-term antiseizure medications have vitamin D3 deficiency, which negatively impacts their QoL. Regular screening and supplementation are recommended for better management of epilepsy.
Segmental versus Extended Resection for Colon Cancer in Lynch's Syndrome
Authors: Hendren Jared R. , Sommovilla Josh 
Published: January 2025

AbstractLynch's syndrome is a common cause of hereditary colorectal cancer (CRC), resulting in higher risk of CRC and development of subsequent, metachronous CRC (mCRC). Beyond treating the primary cancer, surgeons and patients must decide on whether performing an extended colectomy, to reduce the risk of mCRC, is worth the change in function that comes with the larger operation. Considerations include likelihood for mCRC, morbidity and quality of life after resection, impact of pathogenic variant, and certain other cancer risk reduction options. The contemporary evidence to guide these decisions is reviewed herein.
Efficacy of Amniotic Suspension Allografts in the Treatment of Knee Osteoarthritis: A Systematic Review
Authors: Ansari Ayub , Baig Mirza , Tanbour Yazan , Syed Kazi , Ahmed Yunus , Beutel Bryan G. 
Published: January 2025

AbstractKnee osteoarthritis significantly impacts mobility and quality of life. This condition is a leading cause of disability in aging populations, with total knee replacement commonly sought in advanced cases. Traditional nonoperative management strategies, including anti-inflammatories, corticosteroid injections, and hyaluronic acid, often provide limited relief, especially in severe cases. Recently, regenerative therapies such as amniotic suspension allografts (ASA) have emerged as promising alternatives due to their anti-inflammatory and regenerative properties, which may counteract the catabolic effects of osteoarthritis. This systematic review evaluated the efficacy and safety of ASA in reducing pain and improving function among knee osteoarthritis patients. Following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines, a comprehensive search of PubMed and Embase databases initially identified 1,733 studies pertaining to ASA, of which 1,575 were screened, and 9 studies ultimately met the inclusion criteria for detailed analysis of ASA in the treatment of knee osteoarthritis. Data extraction and narrative synthesis focused on outcomes such as pain reduction and functional improvement using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), as well as safety profiles. The results demonstrated notable improvements in pain scores following ASA treatment, as shown by studies reporting increases in KOOS pain scores over 6 months, which generally outperformed hyaluronic acid and saline treatments in pain reduction. Similarly, ASA treatment was associated with substantial improvements in physical function outcome scores, enhancing patients' ability to perform daily activities. Patient-reported outcomes also indicated higher quality of life and functional status, with most patients experiencing high levels of satisfaction. Additionally, ASA's safety profile was favorable, with adverse events primarily mild to moderate in nature, including a few transient events such as knee stiffness and myalgias. This systematic review highlights ASA as an effective therapeutic option for knee osteoarthritis, although further studies focusing on long-term radiographic outcomes and mechanisms of action are recommended to fully establish its benefits and optimize treatment protocols.
Is It Safe to Use Tranexamic Acid for Chronic Subdural Hematoma: A Systematic Review and Meta-Analysis
Authors: Habibi Mohammad Amin , Naseri Alavi Seyed Ahmad , Boskabadi Amir Reza , Seraj Farid Qoorchi Moheb , Mirjnani Mohammad Sina , Benam Mohsen , Salehpour Firooz , Koets Andrew J. 
Published: January 2025

AbstractTrans-4-(aminomethyl)-cyclohexane-1-carboxylic acid, also known as tranexamic acid (TXA), has occasionally been used to prevent postoperative recurrence of chronic subdural hematoma (CSDH) after burr hole craniotomy (BC). However, there is a lack of data about the safety and efficacy of TXA administration after BC. This systematic review and meta-analysis adhered to the Cochrane Handbook Standards Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and searching databases up to January 2024 for randomized controlled trials and cohort studies evaluating TXA. The primary outcome was CSDH recurrence and reoperation. The secondary outcome was thrombosis risk and mortality rate. Ten studies were included, comprising 14,836 patients with CSDH who underwent surgical treatment. Five studies were randomized controlled trials, while the other two case series and three cohort studies. The overall pooled hematoma recurrence rate in the group of patients who used TXA as an adjuvant treatment to the surgical intervention (TXA group), compared with patients who only used surgery to treat CSDH (control group), was 0.05 (95% confidence interval [0.03–0.08], p < 0.01), indicating a significant reduction in recurrence with TXA treatment. TXA, as an adjuvant treatment to the surgical intervention, reduces the risk of postoperative hematoma recurrence, reoperation, thromboembolic complication, and mortality related to CSDH after BC in elderly patients.