bluuebunny/crossref_metadata_2025_split huggingface dataset:
BIMTakt – Optimierung der Produktionsplanung durch ganzheitliche Integration von BIM und Lean Construction
Authors: Becker Steven , Tschickardt Thomas 
Published: January 2023

AbstractNach wie vor wird der Großteil der Bauprojekte mittels längst überholter Werkzeuge geplant und gesteuert. Projektspezifische Informationen werden aus einfachen 2D‐Planzeichnungen entnommen. Die spätere terminliche Steuerung der Bauausführung wird immer noch mit Balkenterminplänen durchgeführt. Der große Nachteil ist, dass diese meist statische Form der Informationsweitergabe mit einem hohen Fehlerpotenzial einhergeht, denn viele Bauprojekte sind gekennzeichnet durch sich stetig ändernde Rahmenbedingungen, die eine dynamische Reaktion zu jeder Projektphase erfordern. Die digitale BIM‐basierte Arbeitsmethode (Building Information Modeling) ist in diesem Zusammenhang ein zentrales Werkzeug, um bereits in frühen Projektphasen eine verlässlichere Planung sicherzustellen und Informationsbrüche zu minimieren. In den letzten Jahren konnte sich zudem die Methode des Lean Construction Management einschließlich verschiedener Werkzeuge, wie bspw. die Taktplanung und Taktsteuerung zur Optimierung der Terminplanung und Steuerung, in der deutschen Baubranche etablieren. Trotz vielfacher Vorteile werden beide Ansätze gegenwärtig noch nicht in einer ganzheitlichen Weise miteinander kombiniert. Nachfolgend wird daher ein Konzept entwickelt, mit dessen Hilfe eine voll automatisierte Ableitung detaillierter Taktpläne auf Basis eines Bauwerksinformationsmodells ermöglicht wird. Zu Beginn werden die Randbedingungen an einen Lean‐basierten Taktplan evaluiert. Anschließend sollen einem Bauwerksinformationsmodell sowohl die geometrischen als auch die prozessrelevanten Informationen automatisiert entnommen werden, um so einen projektspezifischen Taktplan zu generieren. Dadurch soll der gegenwärtig noch analoge Prozess der Taktplanerstellung automatisiert und in eine modellbasierte Arbeitsweise integriert werden.
Effect of Intermediate Radicals on NOx and De‐NOx Characteristics of NH3/H2/Air Flames at High Pressure
Authors: Singh Anand Shankar , Sharma Debojit , Dash Sukanta Kumar , Vanteru Mahendra Reddy 
Published: January 2023

AbstractThe effect of NH, NH2, and HNO on NOx and De‐NOx chemistry of a NH3/H2/air mixture at a pressure of 20 bar is investigated. Results suggest that the increase in pressure reduces NOx emissions and increases HO2 radical production through the reaction H + O2(+M) → HO2(+M). In contrast with OH and O radicals, the HO2 radical is less reactive, which prevents NO formation. The fuel‐bound NOx emissions mainly depend on the reactions NH + OH → NO + H, HNO(+M) → NO + H(+M), HNO + OH → NO + H2O, and HNO + O2 → NO + HO2, and thermal NOx depends on the reactions N + O2 → NO + N and N + OH → NO + H. At a pressure of 20 bar, the N2O is further converted to NO2 and N2 through the reaction N2O + NO → NO2 + N2. The abundance of HO2 radicals at high pressure also initiates the conversion of NO to NO2 via the reaction NO + HO2 → NO2 + H.
Revealing the Impact of Different Iron‐Based Precursors on the ‘Catalytic’ Graphitization for Synthesis of Anode Materials for Lithium Ion Batteries
Authors: Frankenstein Lars , Glomb Pascal , Ramirez‐Rico Joaquin , Winter Martin , Placke Tobias , Gomez‐Martin Aurora 
Published: January 2023

AbstractLow cost and environmentally friendly production of graphite anodes from naturally available biomass resources is of great importance to satisfy the increasing material demand for lithium ion batteries. Herein, graphitization of coffee ground was performed using four different iron‐based activating additives, including iron (III) chloride, iron (III) nitrate, iron (III) oxide and pure iron, following either a wet or a dry mixing approach. The structural development regarding the type of activator used and the impact on the corresponding electrochemical performance are systematically investigated. A maximum degree of graphitization between 55 and 74 % (as determined by Raman spectroscopy) is attained using iron (III) chloride and iron powder, respectively. The graphitic anode material synthesized using iron powder reached a maximum reversible capacity of ≈320 mAh g−1 at a rate of 0.1 C. This study provides significant insights into the impact of activators on the design of synthetic graphite from renewable sources.
Energy Harvesting: Synthetic Use of Recovered Energy in Electrochemical Late‐Stage Functionalization
Authors: Karl Tobias A. , Seidl Max , König Burkhard 
Published: January 2023

AbstractAn induction‐based energy harvesting (EH) device was presented. It converted part of the rotational energy of magnetic stirrers back into electrical energy, making it accessible for electrochemical transformations. After rectification, the induced AC voltage was optionally provided as a constant voltage or constant current whereby the available voltage could directly be adjusted by the stirring rate of the reaction. The comparability of the results with reactions carried out with commercial power supplies has been demonstrated on six different late‐stage functionalization, including methylation, carboxylation, trifluoromethylation, imidation, hydrolysis, and keto‐olefin coupling. Therefore, the described EH device is a low‐cost, resource‐efficient alternative to a commercial electrochemical set‐up and enables laboratories without specialized equipment to perform electrochemical reactions.
Synthesis of Cationic Silver Nanoparticles with Highly Potent Properties against Oral Pathogens and Their Biofilms
Authors: He Yanping , Ketagoda Don Hashan Kevin , Bright Richard , Britza Susan Marie , Zechner Joshua , Musgrave Ian , Vasilev Krasimir , Zilm Peter 
Published: January 2023

AbstractDental caries is a major disease associated with the proliferation of acidogenic bacterial species such as Streptococcus mutans that are part of the commensal microbiota of the mouth. Silver nanoparticles (AgNPs) are attractive antibacterial agents as they target multiple sites in bacteria which reduces antimicrobial resistance. In this study, we synthesised stable, highly positively charged AgNPs capped with branched PEI (BPEI‐AgNPs) and characterized them using UV–vis absorption, transmission electron microscopy (TEM), the size of which were approximately 7.5 nm. The antibacterial activity and anti‐biofilm capacity of BPEI‐AgNPs was investigated against cariogenic bacteria. Our results demonstrated that BPEI‐AgNPs are potent clinical oral antiseptics. The cytotoxicity of the BPEI‐AgNPs was also studied against two mammalian cell lines. The results indicated that BPEI‐AgNPs were non‐cytotoxic and were safer than commercially used dental antiseptics. We conclude that the BPEI‐AgNPs are safe for oral clinical application and are an effective oral antimicrobial agent.
The association between high‐risk human papillomavirus and oral lichen planus
Authors: Mohammadi Maryam , Abbaszadeh Hamid , Mohtasham Nooshin , Salehiniya Hamid , Shafaie Ebrahim 
Published: January 2023

AbstractObjectivesOral lichen planus (OLP) is a cell‐mediated inflammatory mucosal disorder and is classified as an oral potentially malignant disorder. Some research has shown that apoptosis in OLP cells is similar to a viral infection such as human papillomavirus (HPV). So, the aim of this case‐control study was to investigate the association of high‐risk HPV with OLP.Material and MethodsDNA was extracted from 25 formalin‐fixed, paraffin‐embedded (FFPE) OLP tissues and 25 FFPE normal oral tissues as case and control groups, respectively. The presence of high‐risk HPV16 and HPV18 DNA was investigated by polymerase chain reaction (PCR). p‐value<.05 was considered significant.ResultsTwelve samples (48%) of OLPs were positive for HPV16, compared with six samples (24%) of controls; although the difference was not significant, it was borderline (p = .07). Three samples (12%) of OLPs were positive for HPV18 compared with one sample (4%) of controls; the difference was not significant (p = .3). The total frequency of both high‐risk HPV were 14 samples (56%) of OLPs and 7 samples (28%) of controls; there was a significant association between the high‐risk HPV and OLP (p = .04). High‐risk HPVs was more prevalent in erosive‐atrophic (EA) form of OLP as compared to non‐EA form, although the difference was not significant (p = .13).ConclusionsThe results suggest a significant association between high‐risk HPVs and OLP.
Alleviative effects of α‐lipoic acid on muscle atrophy via the modulation of TNF‐α/JNK and PI3K/AKT pathways in high‐fat diet and streptozotocin‐induced type 2 diabetic rats
Authors: Ko Chih‐Yuan , Wu Chi‐Hao , Huang Wen‐Jian , Lo Yangming Martin , Lin Shih‐Xiang , Wu James Swi‐Bea , Huang Wen‐Chung , Shen Szu‐Chuan 
Published: January 2023

AbstractDiabetes mellitus (DM) is often accompanied by clinical complications such as sarcopenia. Previous studies have indicated that oxidative stress and insulin resistance (IR) are highly associated with the pathogenesis of diabetic myopathy. α‐lipoic acid (ALA), a potent biological antioxidant, exists abundantly in a variety of plants and vegetables. This study aimed to investigate the ameliorative effect of ALA on muscle atrophy in type 2 diabetic rats induced by high‐fat diet feeding (HFD) plus streptozotocin (STZ) injection. The HFD/STZ‐induced diabetic rats were orally administered 50, 100, or 200 mg/kg body weight ALA once a day for 13 weeks. The results showed that ALA at the tested concentrations significantly increased the soleus muscle mass and muscle fibers in diabetic rats. Proinflammatory cytokines, such as tumor necrosis factor (TNF)‐α, were found to decrease in both the serum and muscle of ALA‐treated diabetic rats. ALA significantly reduced the protein‐expression levels of phosphorylated c‐Jun N‐terminal kinase (pJNK)/JNK, forkhead box O3 (FOXO3), and muscle ring‐finger protein‐1 (Murf1); whereas, it enhanced the protein‐expression levels of phosphoinositide 3‐kinase (PI3K), phosphorylated protein kinase B (pAKT)/AKT, myogenin determination gene D (MyoD), the mechanistic target of rapamycin (mTOR), and myosin heavy chain (MyHC) in the soleus muscle of diabetic rats. The results from this study suggested that ALA treatment may preserve soleus muscle mass, alleviate muscle atrophy by suppressing the TNF‐α/JNK pathway, and ameliorate the PI3K/AKT pathway in HFD/STZ‐induced type 2 diabetic rats.
Basal‐like mammary carcinomas stimulate cancer stem cell properties through AXL‐signaling to induce chemotherapy resistance
Authors: Pantelaiou‐Prokaki Garyfallia , Reinhardt Oliver , Georges Nadine S. , Agorku David J. , Hardt Olaf , Prokakis Evangelos , Mieczkowska Iga K. , Deppert Wolfgang , Wegwitz Florian , Alves Frauke 
Published: January 2023

AbstractBasal‐like breast cancer (BLBC) is the most aggressive and heterogeneous breast cancer (BC) subtype. Conventional chemotherapies represent next to surgery the most frequently employed treatment options. Unfortunately, resistant tumor phenotypes often develop, resulting in therapeutic failure. To identify the early events occurring upon the first drug application and initiating chemotherapy resistance in BLBC, we leveraged the WAP‐T syngeneic mammary carcinoma mouse model and we developed a strategy combining magnetic‐activated cell sorting (MACS)‐based tumor cell enrichment with high‐throughput transcriptome analyses. We discovered that chemotherapy induced a massive gene expression reprogramming toward stemness acquisition to tolerate and survive the cytotoxic treatment in vitro and in vivo. Retransplantation experiments revealed that one single cycle of cytotoxic drug combination therapy (Cyclophosphamide, Adriamycin and 5‐Fluorouracil) suffices to induce resistant tumor cell phenotypes in vivo. We identified Axl and its ligand Pros1 as highly induced genes driving cancer stem cell (CSC) properties upon chemotherapy in vivo and in vitro. Furthermore, from our analysis of BLBC patient datasets, we found that AXL expression is also strongly correlated with CSC‐gene signatures, a poor response to conventional therapies and worse survival outcomes in those patients. Finally, we demonstrate that AXL inhibition sensitized BLBC‐cells to cytotoxic treatment in vitro. Together, our data support AXL as a promising therapeutic target to optimize the efficiency of conventional cytotoxic therapies in BLBC.
Age of the onset of menarche and its complications: a literature review
Authors: Rivas Paz Mariana , Torres Mendoza Blanca Miriam , Torres Castillo Nathaly 
Published: January 2023

AbstractBackgroundThe menarche plays an important role in a woman's life, as its onset may generate the development of certain pathologies in the future.ObjectivesTo review the updated bibliography about risk factors related to the age of onset of menarche.Search StrategyA systematic search review of PubMed, Scopus, EMBASE, EBSCO‐Host, Springer Link, and Clinical Key from November 2021 to May 2022.Data Collection and AnalysisFrom each article a descriptive summary organized by first author, year of publication, type of article, characteristics of the study, and results was extracted. The results of the different articles were compared before using them in the current literature review.Main ResultsA total of 15 824 articles were collected, from which 33 articles were used following the inclusion and exclusion criteria. It was found that an early estrogen stimulus triggers a predisposing factor for pathologies such as insulin resistance, asthma and short stature. In contrast, a late estrogenic stimulus generates low bone mineral density.ConclusionsThe importance of menarche as a protective or triggering factor of pathologies helps us to implement preventive measures to avoid these future pathologies.
Association between maternal e‐cigarette use during pregnancy and low gestational weight gain
Authors: Wen Xiaozhong , Thomas Marjorie A. , Liu Lufeiya , Moe Aye A. , Duong Peter H. , Griffiths Malkijah E. , Munlyn Ambra L. 
Published: January 2023

AbstractObjectiveTo evaluate the risk of low gestational weight gain (GWG) in women who use electronic cigarettes (e‐cigarettes), combustible cigarettes, or both e‐cigarettes and combustible cigarettes (dual use) during pregnancy.MethodsWe conducted a secondary analysis of the data from 176 882 singleton pregnancies in the 2016–2020 US Pregnancy Risk Assessment Monitoring System (PRAMS). Postpartum women self‐reported their use of e‐cigarettes and/or cigarettes during the last 3 months of pregnancy. Low GWG was defined as the total GWG less than 12.7 kg, less than 11.3 kg, less than 6.8 kg, and less than 5.0 kg (<28, <25, <15, and < 11 lb) for women with underweight, normal weight, overweight, and obesity, respectively. We used multivariable logistic regression to estimate the odds ratios (ORs) of low GWG, adjusting for confounders.ResultsIn this national sample, 921 (weighted percentage, 0.5%) of women were e‐cigarette users and 1308 (0.7%) were dual users during late pregnancy. Compared with non‐users during late pregnancy (40 090, 22.1%), cigarette users (4499, 28.0%) and dual users (427, 26.0%) had a higher risk of low GWG, but e‐cigarette users had a similar risk (237, 22.1%). Adjustment for sociodemographic and pregnancy confounders moderately attenuated these associations: confounder‐adjusted ORs 1.26 (95% confidence interval [CI] 1.18–1.35) for cigarette users, 1.18 (95% CI 0.96–1.44) for dual users, and 0.99 (95% CI 0.78–1.27) for e‐cigarette users.ConclusionsUnlike combustible cigarette use, e‐cigarette use during late pregnancy does not appear to be a risk factor for low GWG.
Impact of a comprehensive medication management program on ambulatory care patients with noncommunicable diseases in a Latin American hospital: A retrospective study
Authors: Sancho‐Vargas Natalia , Zavaleta‐Monestel Esteban , Arguedas‐Chacón Sebastián 
Published: January 2023

AbstractBackgroundNoncommunicable diseases are the leading causes of death and disability in the world, harming life conditions and increasing expenditures within the health care system. Comprehensive Medication Management (CMM) may improve patient safety, adherence, and clinical outcomes by preventing or intervening in drug‐related problems (DRPs).MethodsRetrospective, cross‐sectional study conducted between October 2017 and July 2022 in a CMM of a hospital in Costa Rica. Patients 3–106 years old diagnosed with at least one chronic disease and had risk factors for DRP were included. A clinical pharmacist (CP) identified DRPs and proposed interventions to resolve them. DRPs were classified into four categories: indication, effectiveness, safety, and adherence. Additionally, the severity of the problem was determined by using a scale of potential clinical consequences avoided related to DRPs and medication errors (MEs). The adherence rate was determined by applying validated questionnaires and traceability control of dispensing medication dates. Clinical outcomes were classified as resolved, improved, stable, worsened, and therapeutic failure according to the condition of the DRP until the last appointment by the patient.ResultsPharmacotherapy interventions had an overall acceptance rate of 98.3%. Interventions made by the CP were related to effectiveness (38.9%, n = 253), safety (29.6%, n = 193), adherence (20.90%, n = 136), and therapy indications (10.60%, n = 69). The patient adherence rate improved, with a mean value of 74% on the first appointment compared with 88% as the last value calculated after the pharmacist's interventions. Predominant determinants of medication nonadherence were therapy‐related factors (30.88%) and patient‐related factors (30.15%). In the clinical status assessment of 651 DRPs, 490 (75.3%) resolved, 105 (16.1%) improved, 43 (6.6%) remained stable, 5 (0.8%) worsened, and 8 (1.2%) patients presented with therapeutic failure.ConclusionsCPs can help resolve DRPs/MEs which enable patients to achieve medication‐related therapeutic goals. The clinical interventions made were characterized according to the outcomes of each patient to obtain the optimal management of a patient's medications.
An efficient and green synthesis of multi‐heteroatom heterocycles via a three components reaction in acetic acid/aqueous condition
Authors: Yang Shuang , Peng Yani , Wu Minyang , Yang Jing , Chen Xingyue , Rong Liangce 
Published: January 2023

AbstractIn this research, the multi‐heteroatom heterocycles were effectively obtained via three components reactions from isatins, 3‐aminopyrazol‐5(4H)‐one, and the different heterocyclic ketones (kojic acid, ethyl 4‐oxopiperidine‐1‐carboxylate, and tetrahydro‐4H‐thiopyran‐4‐one) under acetic acid/aqueous condition for the first time. The advantages of the approach were easy to handle, excellent yields, a wide range of substrates and environmental friendliness. This study provided an alternative synthesis pathway for obtaining multi‐heteroatom heterocycle compounds.
Spatiotemporal analysis of consecutive extreme wet days in China from 1980 to 2020
Authors: Zong Xuezheng , Yin Yunhe , Cui Tong , Hou Wenjuan , Deng Haoyu 
Published: January 2023

AbstractConsecutive extreme wet days (CEWDs) typically affect the likelihood of flooding and landslides and have negative effects on both natural and artificial ecosystems; however, the spatiotemporal changes in their features are still unclear at the national scale. Investigating changes in the frequency and intensity of such events is essential for climate risk management. Here, this study thoroughly analysed CEWD features in China from 1980 to 2020 using the daily observation dataset. We also evaluated and compared the ability of two widely used precipitation products, the European Centre for Medium‐Range Weather Forecasts Reanalysis 5th Generation (ERA5) and the Multi‐Source Weighted‐Ensemble Precipitation version 2 (MSWEP), to detect CEWD features. According to the observation data, the frequency and intensity of CEWD events are related to local climate and present “high eastern and low western” spatial patterns across China. Since 1980, more than half of China's mainland has experienced increases in both the frequency and intensity of CEWDs. Some stations detected decreasing trends in CEWD frequency and amounts, which are primarily located in the eastern coastal regions and southwest of warm temperate humid/subhumid regions. The ERA5 precipitation product generally outperforms MSWEP data in detecting CEWD events, and the latter significantly underestimates the annual frequency and amounts of CEWDs. These findings provide basic and valuable information regarding CEWD features across China and where such studies can be conducted based on precipitation datasets. Furthermore, these findings will also aid policymakers in managing extreme precipitation‐related natural hazards.
Solidification of concentrated pea protein–pectin mixtures as potential binder
Authors: Moll Pascal , Salminen Hanna , Stadtmüller Lucie , Schmitt Christophe , Weiss Jochen 
Published: January 2023

AbstractBACKGROUNDBinders in plant‐based meat analogues allow different components, such as extrudate and fat particles, to stick together. Typically, binders then are solidified to transform the mass into a non‐sticky, solid product. As an option for a clean‐label binder possessing such properties, the solidification behavior of pea protein–pectin mixtures (250 g kg−1, r = 2:1, pH 6) was investigated upon heating, and upon addition of calcium, transglutaminase, and laccase, or by combinations thereof.RESULTSMixtures of (homogenized) pea protein and apple pectin had higher elastic moduli and consistency coefficients and lower frequency dependencies upon calcium addition. This indicated that calcium physically cross‐linked pectin chains that formed the continuous phase in the biopolymer matrix. The highest degree of solidification was obtained with a mixture of pea protein and sugar beet pectin upon addition of laccase that covalently cross‐linked both biopolymers involved. All solidified mixtures lost their stickiness. A mixture of soluble pea protein and apple pectin solidified only slightly through calcium and transglutaminase, probably due to differences in the microstructural arrangement of the biopolymers.CONCLUSIONThe chemical makeup of the biopolymers and their spatial distribution determines solidification behavior in concentrated biopolymer mixtures. In general, pea protein–pectin mixtures can solidify and therefore have the potential to act as binders in meat analogues. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Comparison of Sonographic Characteristics Between Superficial Basal Cell Carcinoma and Non‐Superficial Basal Cell Carcinomas
Authors: Liang Jian‐Feng , Luo Ping‐Ping , Zhang Yan , Zhao Gang , Zhou Mei , Wang Jing 
Published: January 2023

ObjectivesTo compare the sonographic characteristics of superficial basal cell carcinoma (sBCC) and non‐superficial basal cell carcinomas (nsBCC).MethodsThe ultrasound characteristics of 73 basal cell carcinoma (BCC) confirmed by surgical pathology were retrospectively analyzed, and the cases were divided into 11 cases of sBCC and 62 cases of nsBCC according to pathological subtypes. Ultrasound characteristics between groups were compared.ResultsAmong all the ultrasound characteristics, lesion thickness (P = .000), shape (χ2 = 39.293, P = .000), basal changes (χ2 = 8.473, P = .037), infiltration level (χ2 = 46.140, P = .000), and distribution of intralesional hyperechogenic spots (χ2 = 15.699, P = .000) of the lesions had statistically significant correlation with pathological diagnosis of sBCC. While no significant differences were shown in surface morphology, keratinization, maximum diameter, intralesional echogenicity, posterior echogenic changes, and intralesional color Doppler flow of the lesions.ConclusionsSmall lesion thickness, oblate shape, superficial dermal local infiltration, and <3 internal hyperechogenic spots distribution of BCC determined by high frequency ultrasound may positively correlate with pathological diagnosis of sBCC. This is beneficial for treatment planning.