bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling growth and formation of thrombi: a multiphasic approach based on the theory of porous media
Authors: Gupta Ishan , Schanz Martin 
Published: August 2023

AbstractAortic dissection (AD) has a high mortality rate. About 40% of the people with type B AD do not live for more than a month. The prognosis of AD is quite challenging. Hence, we present a triphasic model for the formation and growth of thrombi using the theory of porous media (TPM). The whole aggregate is divided into solid, liquid and nutrient constituents. The constituents are assumed to be materially incompressible and isothermal, and the whole aggregate is assumed to be fully saturated. Darcy’s law describes the flow of fluid in the porous media. The regions with thrombi formation are determined using the solid volume fraction. The velocity- and nutrient concentration-induced mass exchange is defined between the nutrient and solid phases. We introduce the set of equations and a numerical example for thrombosis in type B AD. Here we study the effects of different material parameters and boundary conditions. We choose the values that give meaningful results and present the model’s features in agreement with the Virchow triad. The simulations show that the thrombus grows in the low-velocity regions of the blood. We use a realistic 2-d geometry of the false lumen and present the model’s usefulness in actual cases. The proposed model provides a reasonable approach for the numerical simulation of thrombosis.
Differences in the learning curve of robotic transabdominal preperitoneal inguinal hernia repair according to surgeon’s robotic experience
Authors: Solaini L. , Cavaliere D. , Rocco G. , Avanzolini A. , Di Pietrantonio D. , Ercolani G. 
Published: August 2023

AbstractPurposeIn this study, we aim to analyze the learning curve of each step of robotic transabdominal pre-peritoneal inguinal hernia repair (rTAPP) in two surgeons with varying degrees of expertise with the robotic platform but no experience with laparoscopic hernia repair.MethodsData on 124 rTAPP cases performed by two surgeons were retrospectively reviewed. Cumulative sum (CUSUM) analysis was applied to visualize the learning curve of rTAPP on operation time of each step of the procedure [the peritoneal flap creation (T1), the completion of the critical view of the myopectineal orifice (T2), the mesh application (T3) and the peritoneal flap closure (T4)]. Each intraoperative and postoperative outcome was compared according to surgeon’s experience with the robotic platform and learning phase. The robotic surgeon mentored the surgeon-in-training and was present during all surgeries in his learning period.ResultsThe surgeon in training with the robotic platform showed a learning phase till the 20th procedure followed by a gradual improvement in performances. The expert surgeon showed a learning phase till the 35th procedure after which a constant decrease of operative time was recorded till the last procedure included. The operative times of each step of the procedures of both surgeons were significantly improved after the learning phase. In the late phase, the surgeon in training could achieve operative times in T2 and T3, which are similar to those of an experienced robotic surgeon with no experience with TAPP before the completion of the learning phase.ConclusionsIn conclusion, the learning phase of rTAPP surgery may vary between 20 and 35 cases, depending on the surgeon’s experience in robotic surgery.
The impact of vascular volume fraction and compressibility of the interstitial matrix on vascularised poroelastic tissues
Authors: Mascheroni Pietro , Penta Raimondo , Merodio José 
Published: August 2023

AbstractIn this work we address the role of the microstructural properties of a vascularised poroelastic material, characterised by the coupling between a poroelastic matrix and a viscous fluid vessels network, on its overall response in terms of pressures, velocities and stress maps. We embrace the recently developed model (Penta and Merodio in Meccanica 52(14):3321–3343, 2017) as a theoretical starting point and present the results obtained by solving the full interplay between the microscale, represented by the intervessels’ distance, and the macroscale, representing the size of the overall tissue. We encode the influence of the vessels’ density and the poroelastic matrix compressibility in the poroelastic coefficients of the model, which are obtained by solving appropriate periodic cell problem at the microscale. The double-poroelastic model (Penta and Merodio 2017) is then solved at the macroscale in the context of vascular tumours, for different values of vessels’ walls permeability. The results clearly indicate that improving the compressibility of the matrix and decreasing the vessels’ density enhances the transvascular pressure difference and hence transport of fluid and drug within a tumour mass after a transient time. Our results suggest to combine vessel and interstitial normalization in tumours to allow for better drug delivery into the lesions.
Rockfalls, fragmentation, and dust clouds: analysis of the 2017 Pousset event (Northern Italy)
Authors: Crosta Giovanni B , Dattola Giuseppe , Lanfranconi Camilla , De Blasio Fabio V , Malusà Marco , Bertolo Davide 
Published: August 2023

AbstractThe process and dynamics of rock fragmentation during the collapse of rockfalls and rock avalanches is a poorly developed topic. The most severe fragmentation often leads to the formation of a rock dust that rises to form a cloud suspended in the air. The understanding of fragmentation processes is hampered by the environmental disturbances that alter the dust cloud deposit shortly after deposition. Here, we study the fragmentation of the October 2017 Pousset rockfall, detached from a NNE facing steep bedrock wall in the permafrost zone, that involved 8,300m3 of metamorphic rock and fell about 800 m. The collapse generated large boulders which rolled downslope and a thick and large dust cloud. The source and deposit were investigated, and dust cloud material was sampled at different locations to reconstruct an exponential thickness distribution and perform grain size characterization. The fragmentation energy was estimated by integrating the spectrum of the grains assuming that the fragmentation energy is proportional to the generated area. The fragmentation energy was found to be about 0.4% of the initial potential energy. Most probable fragmentation points and block deposition areas were evaluated and positioned by means of the HyStone 3D rockfall simulator. Furthermore, we calculated the flow rate of the suspended powder generated by the fragmentation process and compared the results with observations available for the evolution of the phenomenon and the collected samples. The Pousset event, in its relatively simple dynamics, may be a good testing ground to address the current theories of rockfall and rock avalanche fragmentation and dust cloud behavior.
How the Lewisian can Account for Kit Fine’s Essentialist Beliefs
Authors: Nencha Cristina 
Published: August 2023

Abstract
The Lewisean counterpart theorist– despite not defending a genuinely essentialist view of what is possible, de re, of individuals – generally has a way to make essentialist claims come out as true, in those contexts in which they are endorsed by a committed essentialist.
In this paper, I am going to show that the normal system that the Lewisean adopts when she wants to make the essentialist a truth-teller does not work with Kit Fine: his essentialist beliefs, which support his counterexamples to the modal account of essentialism, cannot come out as true, in any contexts whatsoever, under the Lewisean view.
After arguing that this represents a genuine problem for Lewis’s theory, I will propose a solution. I will indeed show that the Lewisean has a principled way to account for Fine’s essentialist beliefs, consistently with her own counterpart-theorist reading of them.
Towards an Understanding of the Principle of Variable Embodiments
Authors: Baratella Riccardo 
Published: August 2023

Abstract
The theory of variable embodiments has been primarily formulated to model ordinary objects as things that change their parts over time. A variable embodiment /f/ is a sui generis whole constructed from a principle f, the principle of a variable embodiment, and it is manifested at different times by different things picked out by such a principle f. This principle is usually clarified as a function that picks out, at any given time the variable embodiment exists, its corresponding manifestation at that time, and it fails to pick out anything at any other time. The first purpose of this article is to examine and refute three natural understandings of such a principle. Specifically, first, we argue against the view that it should be understood extensionally as either a partial function or total function. Next, we provide some motivations to reject the understanding of the principle as a function in intensional terms, where the notion of intension is analyzed in terms of a specific version of a possible world semantics. The second goal of the article is to make it plausible that the principle has an intensional character and, on the basis of the results achieved, to formulate some constraints that an account of such a principle should meet.
Transcriptomic profiling of human granulosa cells between women with advanced maternal age with different ovarian reserve
Authors: Jia Zhi-cheng , Li Yong-qian , Zhou Bo-wen , Xia Qing-chang , Wang Pei-xuan , Wang Xiao-xuan , Sun Zhen-gao , Guo Ying 
Published: August 2023

Abstract
Background
Age-related diminished ovarian reserve (DOR) is not absolute. Some advanced maternal age (AMA) still have normal ovarian reserve (NOR) and often show better pregnancy outcomes. Exploring the transcriptomic profile of granulosa cells (GCs) in AMA could lead to new ideas for mitigating age-related diminished ovarian reserve.

Aim
This study aimed to analyze the transcriptomic profile of GCs in AMA with different ovarian reserve.

Results
In total, 6273 statistically significant differential expression genes (DEGs) (|log2fc|> 1, q < 0.05) were screened from the two groups, among which 3436 genes were upregulated, and 2837 genes were downregulated in the DOR group. Through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, the potential functions of dysregulated genes in AMA with DOR or NOR were predicted. The GO enrichment analysis revealed that the DEGs were mainly enriched in obsolete oxidation–reduction process, mitochondrion, metal ion binding, ATP binding, etc. The KEGG pathway enrichment analysis revealed that the above-mentioned DEGs were mainly enriched in ferroptosis, regulation of actin cytoskeleton, oxidative phosphorylation, etc. Meanwhile, verification of the mRNA expression levels of DEGs revealed the possible involvement of “ferroptosis” in age-related diminished ovarian reserve.

Conclusions
From a new clinical perspective, we presented the first data showing the transcriptomic profile in GCs between AMA with different ovarian reserve. At the same time, we identified the role of ferroptosis in the GCs of AMA, providing a new biological basis for studying ovarian aging and improving pregnancy outcomes of AMA.
Aggregation of organically managed fields promotes aphid parasitism in cereal crops under Mediterranean conditions
Authors: Salat-Moltó Agnès , Blanco-Moreno José M. , Pérez Hidalgo Nicolás , Michelena José M. , Ferrer Suay Mar , Guerrieri Emilio , Caballero-López Berta 
Published: August 2023

Abstract
Context
Maintaining a balance between semi-natural habitats and arable land is not always feasible for farmers. The promotion of biological control agents can be addressed through management at farm or field level, and/or by deploying lower intensity, biodiversity-friendly practices which can act either directly or indirectly through their effect of the plant community.

Objectives
We studied the effects on cereal aphids and their parasitoids of agricultural management at field and landscape levels. We tested the effect of organic and conventional farming, and of the within field characteristics, on the cereal aphid-parasitoid community, across a gradient of organic farming aggregation and of percentage of arable land.

Methods
In spring 2015, we sampled aphid populations in 30 cereal fields in five agricultural areas in Catalonia (Spain) with contrasting levels of organic farming aggregation. In each field, we also assessed weed and crop cover. As landscape variables, we calculated the Percentage of Agricultural Land (PAL) and the Percentage of Organically Managed Land (POML) in a 500-m buffer around each field. We sampled cereal tillers 3 m from the field edges and collected all aphids detected. In addition, we reared mummies (parasitized aphids) until they hatched.

Results
Our results show that management at landscape level has significant effects on parasitism rates: a higher proportion of surrounding fields under organic management increased the amount of parasitism, as did less agricultural land cover. On the other hand, aphid populations were mainly affected by two in-field factors, namely, crop density and crop variety. Differences in weed communities did not seem to have any effects on either aphids or parasitoids.

Conclusions
Rather than concentrating on the individual management of fields, a coordinated implementation of organic farming at landscape level would seem to be a much better strategy for improving the biological control of aphids.
On the viscosity approximation type iterative method and its non-linear behaviour in the generation of Mandelbrot and Julia sets
Authors: Kumari Sudesh , Gdawiec Krzysztof , Nandal Ashish , Kumar Naresh , Chugh Renu 
Published: August 2023

AbstractIn this paper, we visualise and analyse the dynamics of fractals (Julia and Mandelbrot sets) for complex polynomials of the form $$T(z) = z^{n} + mz + r$$

T

(
z
)

=

z
n

+
m
z
+
r

, where $$n \ge 2$$

n
≥
2

and $$m, r \in \mathbb {C}$$

m
,
r
∈
C

, by adopting the viscosity approximation type iteration process which is most widely used iterative method for finding fixed points of non-linear operators. We establish a convergence condition in the form of escape criterion which allows to adapt the escape-time algorithm to the considered iteration scheme. We also present some graphical examples of the Mandelbrot and Julia fractals showing the dependency of Julia and Mandelbrot sets on complex polynomials, contraction mappings, and iteration parameters. Moreover, we propose two numerical measures that allow the study of the dependency of the set shape change on the values of the iteration parameters. Using these two measures, we show that the dependency for the considered iteration method is non-linear.
Variation in Polycyclic Aromatic Compound (PAC) Concentrations in a Norway Spruce Stand Close to a Major Traffic Route—Influence of Distance and Season
Authors: Klingberg Jenny , Strandberg Bo , Grundström Maria , Sjöman Henrik , Wallin Göran , Pleijel Håkan 
Published: August 2023

AbstractAir concentrations of polycyclic aromatic compounds (PACs) were measured in a Norway spruce (Picea abies) stand at four different distances from a major traffic route near Gothenburg, Sweden, during summer and winter 2019, using passive samplers. In total, the concentrations of 32 polycyclic aromatic hydrocarbons (PAHs) and six dibenzothiophenes (DBTs) and NO2 were analysed. PAC air concentrations were on average 2.5 times higher during the winter compared to the summer. All investigated PAH categories and compounds as well as dibenzothiophene declined linearly with the logarithmic distance from the traffic route. This indicates that the length of pollutant pathways through vegetation is a valid proxy to assess health risks of traffic-related PAC pollutants. Concentrations of heavier PAHs declined faster (concentration at site furthest away from the road was 6% and 33% of concentration at site closest to road, for summer and winter respectively) with increasing distance from traffic compared to lighter PAHs (63% and 68% for summer and winter respectively). As a result, the mix of PAHs changed with the depth into the forest stand (i.e. distance from the road) with potential effects on the toxicity as well as on diagnostic ratios used for source attribution. This is likely caused by different deposition rates among the PAH compounds to the vegetation surfaces, although the exact mechanism needs to be further investigated. This study provides new information that can improve air quality risk assessment and limit the exposure of the population to toxic air pollutants such as PACs.
Diurnal variation in variables related to cognitive performance: a systematic review
Authors: Munnilari Madhavi , Bommasamudram Tulasiram , Easow Judy , Tod David , Varamenti Evdokia , Edwards Ben J. , Ravindrakumar Aishwarya , Gallagher Chloe , Pullinger Samuel A. 
Published: August 2023

Abstract
Purpose
The aim of this review was to assess current evidence regarding changes in cognitive function according to time-of-day (TOD) and assess the key components of research design related to manuscripts of chronobiological nature.

Methods
An English-language literature search revealed 523 articles through primary database searches, and 1868 via organization searches/citation searching. The inclusion criteria were met by eleven articles which were included in the review. The inclusion criteria set were healthy adult males, a minimum of two timepoints including morning and evening, cognitive measures of performance, and peer-reviewed academic paper.

Results
It was established that cognitive performance varies with TOD and the degree of difference is highly dependent on the type of cognitive task with differences ranging from 9.0 to 34.2% for reaction time, 7.3% for alertness, and 7.8 to 40.3% for attention. The type of cognitive function was a determining factor as to whether the performance was better in the morning, evening, or afternoon.

Conclusion
Although some studies did not establish TOD differences, reaction time and levels of accuracy were highest in the evening. This implies that cognitive processes are complex, and existing research is contradictory. Some studies or cognitive variables did not show any measurable TOD effects, which may be due to differences in methodology, subjects involved, testing protocols, and confounding factors. No studies met all requirements related to chronobiological research, highlighting the issues around methodology. Therefore, future research must use a rigorous, approach, minimizing confounding factors that are specific to examinations of TOD.
Hares from the Late Pleistocene of Ukraine: a phylogenetic analysis and the status of Lepus tanaiticus (Mammalia, Lagomorpha)
Authors: Rabiniak Emilia , Rekovets Leonid , Kovalchuk Oleksandr , Baca Mateusz , Popović Danijela , Strzała Tomasz , Barkaszi Zoltán 
Published: August 2023

AbstractHares (genus Lepus) are widely distributed in Europe, and they are adapted to various types of habitats. Many species are known to hybridise, and previous molecular genetic studies have revealed recurrent introgressions between species at all stages of the genus’s radiation. The Don hare (Lepus tanaiticus) was described from the Late Pleistocene of the Southern Urals and subsequently reported from coeval deposits of various regions of northern Eurasia. It is morphologically close to the mountain hare (Lepus timidus) and recent studies of mitochondrial DNA questioned its status as an independent species. Here we compare cytochrome b and control-region sequences of mtDNA of arctic Lepus, including, for the first time, eight specimens from Late Pleistocene localities of Ukraine, in order to analyse the phylogenetic relationships between representatives of different taxa. The phylogenetic tree and haplotype network analyses do not support the taxonomic distinctness of the Don hare, and only specimens of Lepus arcticus and Lepus othus form monophyletic groups based on the control-region sequences. Instead, L. tanaiticus are scattered among specimens of L. timidus. The obtained results support the hypothesis that the Don hare is an ancient morphotype of L. timidus, and its distinctive morphological traits are the result of increased geographical variation of the latter due to range expansion and adaptation to the specific conditions of the periglacial biome, similarly to other Late Pleistocene small-mammal species.
Haematopoietic Stem Cell Transplantation for the Treatment of Multiple Sclerosis: Recent Advances
Authors: Mariottini Alice , De Matteis Eleonora , Cencioni Maria Teresa , Muraro Paolo A. 
Published: August 2023

Abstract
Purpose of Review
Autologous haematopoietic stem cell transplantation (AHSCT) is increasingly considered a treatment option for patients with multiple sclerosis (MS), an autoimmune demyelinating and degenerative disease of the central nervous system (CNS). AHSCT persistently suppresses inflammation and improves the disease course in large proportions of patients with relapsing–remitting (RR) MS. Aim of this article is to review the relevant new knowledge published during the last 3 years.

Recent Findings
Laboratory studies reported confirmatory and new insights into the immunological and biomarker effects of AHSCT. Retrospective clinical studies confirmed excellent outcomes in RRMS, showing possible superior effectiveness over standard therapies and suggesting a possible benefit in early secondary progressive (SP) MS with inflammatory features. New data on risks of infertility and secondary autoimmunity were also reported.

Summary
Further evidence on the high effectiveness and acceptable safety of AHSCT strengthens its position as a clinical option for aggressive RRMS. Further research is needed to better define its role in treatment-naïve and progressive forms of MS, ideally within randomised clinical trials (RCTs).
2-Methoxyestradiol and Hydrogen Peroxide as Promising Biomarkers in Parkinson’s Disease
Authors: Bastian Paulina , Konieczna Lucyna , Dulski Jarosław , Daca Agnieszka , Jacewicz Dagmara , Płoska Agata , Knap Narcyz , Sławek Jarosław , Bączek Tomasz , Kalinowski Leszek , Drzeżdżon Joanna , Roszmann Anna , Belka Mariusz , Górska-Ponikowska Magdalena 
Published: August 2023

AbstractEstrogens function in numerous physiological processes including controlling brain cell growth and differentiation. 2-Methoxestradiol (2-ME2), a 17β-estradiol (E2) metabolite, is known for its anticancer effects as observed both in vivo and in vitro. 2-ME2 affects all actively dividing cells, including neurons. The study aimed to determine whether 2-ME2 is a potentially cancer-protective or rather neurodegenerative agent in a specific tissue culture model as well as a clinical setup. In this study, 2-ME2 activity was determined in a Parkinson’s disease (PD) in vitro model based on the neuroblastoma SH-SY5Y cell line. The obtained results suggest that 2-ME2 generates nitro-oxidative stress and controls heat shock proteins (HSP), resulting in DNA strand breakage and apoptosis. On the one hand, it may affect intensely dividing cells preventing cancer development; however, on the other hand, this kind of activity within the central nervous system may promote neurodegenerative diseases like PD. Thus, the translational value of 2-ME2’s neurotoxic activity in a PD in vitro model was also investigated. LC–MS/MS technique was used to evaluate estrogens and their derivatives, namely, hydroxy and methoxyestrogens, in PD patients’ blood, whereas the stopped-flow method was used to assess hydrogen peroxide (H2O2) levels. Methoxyestrogens and H2O2 levels were increased in patients’ blood as compared to control subjects, but hydoxyestrogens were simultaneously decreased. From the above, we suggest that the determination of plasma levels of methoxyestrogens and H2O2 may be a novel PD biomarker. The presented research is the subject of the pending patent application “The use of hydrogen peroxide and 17β-estradiol and its metabolites as biomarkers in the diagnosis of neurodegenerative diseases,” no. P.441360.