bluuebunny/crossref_metadata_2025_split huggingface dataset:
Receptive field sizes and neuronal encoding bandwidth are constrained by axonal conduction delays
Authors: Hladnik Tim , Grewe Jan 
Published: January 2023

AbstractStudies on population coding implicitly assume that spikes from the presynaptic population arrive simultaneously at the integrating neuron. In natural neuronal populations, this is usually not the case — neuronal signalling takes time and neuronal populations cover a certain space. The spread of spike arrival times depends on population size, cell density and axonal conduction velocity. We here analyze the consequences of population size and axonal conduction delays on the stimulus encoding performance in the electrosensory system of the electric fishApteronotus leptorhynchus. We experimentally locate p-type electroreceptor afferents along the rostro-caudal body axis and relate locations to neurophysiological response properties. In an information-theoretical approach we analyze the coding performance in homogeneous and heterogeneous populations. As expected, the amount of information increases with population size and, on average, heterogeneous populations encode better than the average same-size homogeneous population if conduction delays are compensated for. The spread of neuronal conduction delays within a receptive field strongly degrades encoding of high-frequency stimulus components. Receptive field sizes typically found in the electrosensory lateral line lobe ofA. leptorhynchusappear to be a good compromise between the spread of conduction delays and encoding performance. The limitations imposed by finite axonal conduction velocity are relevant for any converging network as is shown by model populations of LIF neurons. The bandwidth of natural stimuli and the maximum meaningful population sizes are constrained by conduction delays and may thus impact the optimal design of nervous systems.Author summaryReading out the activity of a population of neurons can yield a more complete picture of the stimulus space. Generally, increasing population sizes increases the amount of information. This applies to homogeneous populations of similarly tuned neurons as well as heterogeneous populations. So far studies on population coding assumed the information to reach the integrating neuron simultanously. But neurons are neither disembodied nor does neuronal signalling happen instantaneously; populations cover a certain space and axonal conduction takes time. The interplay of encoding bandwidth, receptive field respectively population size and axonal conduction velocity has not been addressed before. Our results from the electrosensory system and of model simulations show that stimulus dynamics, receptive field sizes, and conduction velocity have to be factored in when we want to understand the design of nervous systems.
LDL Receptor-Related Protein 5 is a Selective Transporter for Unesterified Polyunsaturated Fatty Acids
Authors: Tang Wenwen , Luan Yi , Yuan Qianying , Li Ao , Chen Song , Menacherry Stanley , Young Lawrence , Wu Dianqing 
Published: January 2023

AbstractPolyunsaturated fatty acids (PUFAs), which cannot be synthesized by animals and must be supplied from the diet, have been strongly associated with human health. However, the mechanisms for their accretion and actions remain poorly understood. Here, we show that LDL receptor-related protein 5 (LRP5), but not its homolog LRP6, selectively transports unesterified PUFAs into a number of cell types. The LDLa ligand-binding repeats of LRP5 directly bind to PUFAs and are required for PUFA transport. LRP5 transports PUFAs via internalization to intracellular compartments including lysosomes, and n-3 PUFAs depends on this transport mechanism to inhibit mTORC1. This LRP5-mediated PUFA transport mechanism suppresses neutrophil extracellular trap formation in neutrophils and protects mice from myocardial injury during ischemia-reperfusion. Thus, this study reveals a previously unknown and biologically important mechanism for PUFA transport and mTORC1 regulation.
Loss or Gain of Function? Effects of Ion Channel Mutations on Neuronal Firing Depend on the Cell Type
Authors: Koch Nils A. , Sonnenberg Lukas , Hedrich Ulrike B.S. , Lauxmann Stephan , Benda Jan 
Published: January 2023

AbstractClinically relevant mutations to voltage-gated ion channels, called channelopathies, alter ion channel function, properties of ionic current and neuronal firing. The effects of ion channel mutations are routinely assessed and characterized as loss of function (LOF) or gain of function (GOF) at the level of ionic currents. Emerging personalized medicine approaches based on LOF/GOF characterization have limited therapeutic success. Potential reasons are that the translation from this binary characterization to neuronal firing especially when considering different neuronal cell types is currently not well understood. Here we investigate the impact of neuronal cell type on the firing outcome of ion channel mutations with simulations of a diverse collection of neuron models. We systematically analyzed the effects of changes in ion current properties on firing in different neuronal types. Additionally, we simulated the effects of mutations in theKCNA1gene encoding the KV1.1 potassium channel subtype associated with episodic ataxia type 1 (EA1). These simulations revealed that the outcome of a given change in ion channel properties on neuronal excitability is cell-type dependent. As a result, cell-type specific effects are vital to a full understanding of the effects of channelopathies on neuronal excitability and present an opportunity to further the efficacy and precision of personalized medicine approaches.Significance StatementAlthough the genetic nature of ion channel mutations as well as their effects on the biophysical properties of an ion channel are routinely assessed experimentally, determination of their role in altering neuronal firing is more difficult. In particular, cell-type dependency of ion channel mutations on firing has been observed experimentally, and should be accounted for. In this context, computational modelling bridges this gap and demonstrates that the cell type in which a mutation occurs is an important determinant in the effects of neuronal firing. As a result, classification of ion channel mutations as loss or gain of function is useful to describe the ionic current but should not be blindly extend to classification at the level of neuronal firing.
Damage-induced senescent immune cells regulate regeneration of the zebrafish retina
Authors: Konar Gregory , Flickinger Zachary , Sharma Shivani , Vallone Kyle , Lyon Charles , Doshier Claire , Lyon William , Patton James G. 
Published: January 2023

AbstractZebrafish spontaneously regenerate their retina in response to damage through the action of Müller glia. Even though Müller glia (MG) are conserved in higher vertebrates, the capacity to regenerate retinal damage is lost. Recent work has focused on the regulation of inflammation during tissue regeneration with precise temporal roles for macrophages and microglia. Senescent cells that have withdrawn from the cell cycle have mostly been implicated in aging, but are still metabolically active, releasing pro-inflammatory signaling molecules as part of the Senescence Associated Secretory Phenotype (SASP). Here, we discover that in response to retinal damage, a subset of cells expressing markers of microglia/macrophages also express markers of senescence. These cells display a temporal pattern of appearance and clearance during retina regeneration. Premature removal of senescent cells by senolytic treatment led to a decrease in proliferation and incomplete repair of the ganglion cell layer after NMDA damage. Our results demonstrate a role for modulation of senescent cell responses to balance inflammation, regeneration, plasticity, and repair as opposed to fibrosis and scarring.
Size-Dependent Expression of the Fission Yeast Cdc13 Cyclin is Conferred by Translational Regulation
Authors: Bashir Samirul , Sun Xi-Ming , Zhao Yixuan , Martínez-Illescas Nuria G. , Gallego-López Isabella , Negrón Lauren Guerrero , Keifenheim Daniel , Karadimitriou Tatiana , Tran Thi , Pickering Mary , Marguerat Samuel , Rhind Nicholas 
Published: January 2023

AbstractTwo fission yeast mitotic activators, Cdc13 and Cdc25, have been shown to increase in concentration in correlation with cell size, and have been proposed to thereby regulate cell size at division. Here, we show that the expression of both Cdc13 and Cdc25 are, in fact, size dependent, as apposed to simply sizecorrelated due to time-dependent expression. However, we also find that their size dependence is regulated by different mechanisms. Cdc25 was known to be regulated transcriptionally. Here, we show that Cdc13 is regulated translationally. Its transcript is not expression is a size-dependent manner, rather a size-dependent concentration of protein is expressed from a size-independent concentration of mRNA. Moreover, the degradation rate of Cdc13 is not size dependent, implicating size-dependent translation in its regulation. We identify a 20-amino-acid motif, which includes the APC D-box degron, as necessary and sufficient for sizedependent expression, which allowed us to construct a size-independent allele ofcdc13. Using this allele, in combination with a size-independent allele ofcdc25, expressed from a size-independent promoter, we show that size-dependent expression of neither Cdc13 nor Cdc25 is required for size control, nor are the redundantly required for size control.
Estradiol regulates voltage-gated potassium currents in corticotropin-releasing hormone neurons
Authors: Power Emmet M. , Ganeshan Dharshini , Iremonger Karl J. 
Published: January 2023

AbstractCorticotropin-releasing hormone (CRH) neurons are the primary neural population controlling the hypothalamic–pituitary–adrenal (HPA) axis and the secretion of adrenal stress hormones. Previous work has demonstrated that stress hormone secretion can be regulated by circulating levels of estradiol. However, the effect of estradiol on CRH neuron excitability is less clear. Here we show that chronic estradiol replacement following ovariectomy increases two types of potassium channel currents in CRH neurons; fast inactivating voltage-gated A-type K+channel (IA) currents and non-inactivating M-type K+currents (IM). Despite the increase in K+currents following estradiol replacement, there was no overall change in CRH neuron spiking excitability assessed with either frequency-current curves or current ramps. Together, these data reveal a complex picture whereby ovariectomy and estradiol replacement differentially modulate distinct aspects of CRH neuron and HPA axis function.Summary statementChronic estradiol replacement in ovariectomised mice influences voltage-gated potassium channel function.
Topic modeling of the quality of guest’s experience using latent Dirichlet allocation: western versus eastern perspectives
Authors: Sann Raksmey , Lai Pei-Chun 
Published: January 2023

PurposeThis study aims to understand the satisfaction and needs of eastern and western travelers as hotel guest, based on their experiences as seen in guest reviews and review topics.Design/methodology/approachConsidering 2,965 and 1,035 western and eastern traveler reviews, respectively, from 47 countries, obtained from TripAdvisor listed-hotel in Phnom Penh and Siem Reap city in Cambodia, this study investigates the differences in hotel guest satisfaction and needs by using topic modeling (i.e. latent Dirichlet allocation [LDA]).FindingsThe results reveal differences in the online preferences, experiences, expectations and behaviors of hotel guests from different cultural backgrounds. Though western and eastern travelers appear to place similar emphasis on service, location, room and destination. The westerners more likely focus on meal and online reservation, whereas the easterners focus on hotel facility.Research limitations/implicationsReviews were obtained from only two cities in Cambodia, which is not an adequate representation of the diverse travelers visiting the country.Practical implicationsThe comparison highlighting the similarities and dissimilarities between western and eastern traveler perspectives enable hoteliers to understand guests’ preferences and their hidden changes in (dis)satisfaction and leverage it to improve hotel service quality, increase occupancy and, thereby, maximize profits.Originality/valueThis study contributes to the literature on hotel guests’ experiences by presenting the difference in perceptions of service experience of western and eastern travelers, through topic modeling.
Why do self-identity and efficacy matter for enjoying participation in charity sports events? The role of the warm glow feeling
Authors: Chiengkul Watchara , Mahasuweerachai Patcharaporn , Suttikun Chompoonut 
Published: January 2023

PurposeCharity sports events have emerged as a major, beneficial social phenomenon to be encouraged. In this study, the authors aim to examine the relationships among personal norms, social norms, self-identity, response efficacy and the “warm glow” feeling, which, in turn, influences willingness to return and enjoyment of participation in charity sports events in Thailand.Design/methodology/approachAn online self-administered survey was conducted to collect data from 600 participants, and structural equation modelling (SEM) was done under the two-step modelling approach to test the hypotheses.FindingsThe findings indicate that self-identity and response efficacy positively influence participants' warm glow. By contrast, the relationships of personal and social norms with warm glow are not significant. Moreover, warm glow positively influences participants' willingness to return to attend the event and their enjoyment.Practical implicationsThis study's findings have academic implications and can benefit marketers and event organizers by giving them insights into participants' behaviour and allowing them to better create services to improve participant experiences and boost repeat attendance better.Originality/valueBy applying the concept of warm glow in the context of charity sports events, this study deepens the understanding of the causal pathways from the antecedents to participants' willingness to return and enjoyment through the warm glow.
Impact of COVID-19’s supply and demand shocks on the household economy of tilapia smallholder farmer
Authors: Irawan Andi , Anjela Tri Nia , Melli Suryanty S.N. , Yuristia Rahmi 
Published: January 2023

PurposeThis study aims to verify the impact of the supply shock (fall in harvested output) and demand shock (fall in household income) due to the pandemic on the consumption of necessities and household savings of tilapia's smallholder farmer.Design/methodology/approachThe researchers randomly chose 144 households as research samples using the proportional random sampling technique in Padang Jaya District, North Bengkulu Regency. Researchers collected data on household income, farm losses, household consumption for basic needs, labor demand, use of production inputs, the amount of output sold and saving both during and before the pandemic. The data were collected from the sample using a questionnaire prepared by the researchers. This study used a simultaneous equations system for arranging tilapia's smallholder farmer household economic model.FindingsThis study verified that the demand shock phenomenon makes households more severe than the supply shock phenomenon. The demand shock phenomenon made worse-off tilapia smallholder farmers because it caused their household savings to drop during the pandemic. The fall in savings will disrupt the stability of consumption of household necessities (health, food, education and clothing) in the future.Originality/valueThe main contribution of this study was providing empirical evidence about the impact of the demand and supply shock of COVID-19 on the most vulnerable entities in the Indonesian freshwater aquaculture industry, namely, smallholder farmer households of freshwater aquaculture fish.Peer reviewThe peer review history for this article is available at:https://publons.com/publon/10.1108/IJSE-08-2022-0554.
The use of management controls to enhance the perception of meaningful work – a systematic literature review and conceptional model development
Authors: Burghardt Janine , Möller Klaus 
Published: January 2023

PurposeThis study examines the relationship between the use of management controls and the perception of meaningful work. Meaningful work is an important driver of individual performance of managers, and employees and can be enabled by sufficient use of management controls. The purpose of this paper is to address this issue.Design/methodology/approachBased on bibliometric analyses and a structured literature review of academic research studies from the organizational, management and accounting literature, the authors develop a conceptual model of the relationship between the use of management controls and the perception of meaningful work.FindingsFirst, the authors propose that the use of formal management controls in a system (i.e. the levers of the control framework) is more powerful than using unrelated formal controls only. Second, they suggest that the interaction of a formal control system together with informal controls working as a control package can even stretch the perception of meaningful work. Third, they argue that the intensity of the control use matters to enhance the perception of meaningful work (inverted u-shaped relationship).Originality/valueThis study presents the first conceptual model of the relationship between the use of management controls and the perception of meaningful work. It provides valuable implications for practice and future research in the field of performance management.
The regional economic impact of the 2020 COVID-19 recession in the USA
Authors: Connaughton John E. , Cebula Richard J. , Amato Louis H. 
Published: January 2023

Purpose
This paper to identify those states that suffered the largest job losses, largest GDP declines and the highest unemployment rates and those states whose employment levels, unemployment rates and GDP declines were smallest during the COVID-19 recession. In addition, this paper endeavors to provide at least preliminary insights into why some states faired so poorly, whereas other states suffered so little during this downturn.

Design/methodology/approach
This paper uses descriptive statistics and regression analysis to analyze the differences in state performance during the COVID-19 recession and recovery.

Findings
The results from the two estimated regression models suggest that where you lived determined the severity of the recession and living in a blue state negatively impacted the strength of state’s unemployment rate recovery.

Research limitations/implications
This paper looks at only a two-year period starting with the COVID-19 recession and ending in December 2021.

Practical implications
This paper provides a regional assessment of the COVID-19 recession and recovery on both a state and regional level.

Social implications
The paper uses descriptive statistics to characterize the substantial state-level differences in the relative magnitude of economic decline due to the Covid-19 recession. Regression analysis reveals that blue states experienced weaker recovery as compared to red states.

Originality/value
The study uses publicly available data to identify states that suffered the largest job losses and highest peak unemployment rates during the Covid-19 recession. The results are among the first to analyze the economic impact of the Covid-19 recession at the state level.
The impact of the COVID-19 pandemic on corporate tax avoidance: evidence from S&P 500 firms
Authors: Kobbi-Fakhfakh Sameh , Bougacha Fatma 
Published: January 2023

Purpose
This study aims to examine the impact of the COVID-19 pandemic on corporate tax avoidance (TA).

Design/methodology/approach
This study used a panel data set of US publicly traded firms listed in the Standard & Poor 500 index. Based on available information in the DATASTREAM database covering the 2019–2021 period, three proxies for TA are used, namely the current effective tax rate (CUETR), the cash effective tax rate and book-tax differences (BTD). Multiple regression models including industry and year fixed effects are estimated. Additional analyses are performed using BTD components i.e. temporary and permanent BTD, and testing the impact of the COVID-19 pandemic across industries.

Findings
The results show that the outbreak of the novel coronavirus (COVID-19) affected positively the CUETRs and negatively BTD, indicating a reduction in TA, in the postpandemic period. Further analyses provide evidence that this effect is the same, regardless of the degree of industry failure probability, but it is more driven by the reduction of deferred tax expenses (temporary BTD component). These findings suggest that the US publicly listed firms have experienced a serious drop in their income in the postpandemic period, following the markets closure and the quarantine periods that hampered business. Therefore, with lower profits, they are not willing to evade taxes.

Social implications
This paper enriches taxation research during economic crises. The research findings have important policy implications. On the one hand, the fiscal policy should stimulate growth to allow firms to tackle the challenges they confronted post-COVID-19. On the other hand, the global economic crisis caused by the pandemic has led to a major deterioration in public finances and has raised inequalities across households. Therefore, it would be necessary to review public fiscal policies to achieve a balance of equity, growth and sustainability. In this context, tax reform focusing on tax progressivity could counter in part the negative economic effects of the COVID-19 pandemic and led to economy recovery.

Originality/value
This study contributes to the growing body of literature on the COVID-19 effects with a special focus on corporate practices. This study provides first evidence on the effect of the COVID-19 pandemic on manager’s behavior from taxation perspective. This study also enriches taxation research during economic crises.
Effect of phylloquinone on indomethacin‐induced gastric ulceration in rats: Role of SIRT‐1
Authors: Hamza Sara E. , Wahdan Sara A. , El‐Demerdash Ebtehal 
Published: January 2023

AbstractGastric ulcer is the most common gastrointestinal disorder affecting people globally. Although many drugs are available to treat ulcers, the mortality rate is relatively high, and drugs lack selectivity to treat ulcers without causing side effects. In this study, the potential therapeutic effects of phylloquinone were tested against indomethacin‐induced gastric ulcer in rats by giving rats a single oral dose of indomethacin (48 mg/kg), followed by phylloquinone (10 mg/kg) orally, once daily for six consecutive days. Phylloquinone significantly attenuated indomethacin‐induced oxidative and inflammatory responses through hindering the inflammatory cascade by decreasing the levels of TNF‐α, NF‐κB, INOS and COX‐2 which counteracts indomethacin effects. Also, it increased NAD+ which enhanced SIRT‐1 level. Furthermore, phylloquinone was effective in increasing mucus secretion, decreasing acid secretion, reversing histological effects caused by indomethacin and minimizing ulcer and lesion indices All these findings indicate that phylloquinone may be used in protection and treatment of indomethacin‐induced gastric ulcer.