bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience of family of children’s hospitalization at the ICU.
Authors: Martins Faria Faddul Alves Maria Virginia , Gonzaga Cordeiro Juliana , Bronzato Luppi Claudia Helena , Trevizani Nitsche Maria José , Leite Rosa Olbrich Sandra Regina 
Published: April 2023

Objective. To describe the experience of family members as a result of children’s hospitalization at the Intensive Care Unit (ICU).
Methodology. Descriptive and cross-sectional study. A structured interview was held with 20 relatives of patients hospitalized at two clinics of the Botucatu Medical School at Universidade Estadual Paulista “Júlio de Mesquita Filho”. Information was collected between July and September 2010.
Results. The main characteristics of the participating relatives were: 80% mothers of the children; 70% low education level and 70% married. Sixty percent of the children were hospitalized at the ICU for the first time. Eighty percent of the interviewees believe that the children’s behavior changes inside the unit and 85% consider that visiting hours are sufficient. The predominant negative feelings are fear (50%) and insecurity (20%), while the predominant positive feelings are hope (50%) and the expectation of discharge (25%). The professional who most supported the relatives was the nurse (35%).
Conclusion. The family members’ experience as a result of the children’s hospitalization at the ICU involves positive and negative aspects, which also affect the child’s behavior at the unit.
Assessment of nursing students’ self-esteem.
Authors: Lopes Chaves Erika Cássia , Simão Talita Prado , De Oliveira Iara Siqueira , De Souza Isis Prado , Iunes Denise Hollanda , Nogueira Denismar Alves 
Published: April 2023

Objective. To assess the self-esteem of nursing students and explore its relationship with professional training factors that could affect it.
Methodology. Descriptive research, involving 135 nursing students at a university in the South of the state of Minas Gerais (Brazil). Data collection was performed between May and September 2011, using a self-report form that collected information about the sociodemographic characteristics and satisfaction with the career chosen, as well as the Rosenberg Self-Esteem Scale.
Results. From the total, 90% of students were female, 41% were 20 years of age or younger, and 96% were single. One in each three was taking the first year of their program. Concerning the self-esteem level, 68% presented high self-esteem, 30% average and 2% low. A positive relationship was found between the level of self-esteem and professional perspective (p=0.011).
Conclusion. Most nursing students presented high self-esteem, which was related to the professional perspective.
Risk of eating behavior disorders in adolescents from Cartagena, Colombia
Authors: Cogollo Zuleima , Gómez-Bustamante Edna Margarita 
Published: April 2023

Objective. To estimate the prevalence and explore the relationship of the risk of eating behavior disorders (REDB) with some factors in school-age adolescents from Cartagena, Colombia.
Methodology. This was a cross-sectional study, which used probability sampling by conglomerates of high school students (sixth to eleventh grades) in 2012. The REDB was quantified with the SCOFF questionnaire (two or more points). The associations were fitted through a logistic regression model.
Results. A total of 2625 students between 10 and 20 years of age (mean = 14 years) participated; 54% were women. A total of 32.5% scored for REDB. The risk factors associated were: problematic consumption of alcohol (OR=1.9; CI95%: 1.4-2.5), female sex (OR=1.6; CI95%: 1.4-1.9), non-heterosexual sexual orientation (OR=1.5; CI95%: 1.1-2.1), consumption of any illegal substance (OR=1.5; CI95%: 1.1-2.1), cigarette smoking at any moment in life (OR=1.5; CI95%: 1.2-1.8), depressive symptoms with clinical importance (OR=1.5; CI95%: 1.2-1.8), and family dysfunction (OR=1.2; CI95%: 1.1-1.5).
Conclusion. An important proportion of school-age adolescents from Cartagena presented REDB, which was mainly related to problematic consumption of alcohol and the female sex.
GAGE gene and protein expression profile in cancer patients
Authors: Rudakova A. A. , Shirin A. D. , Golubtsova N. V. , Pinyugina M. V. , Misyurin V. A. 
Published: April 2023

Cancer-testis antigens (CTA) are antigens expressed by tumor cells of various histological types, but practically absent in cells of normal tissues, with the exception of germ cells. CTA includes more than 100 proteins, most of which are grouped into large families. Currently, the use of CTA for immunotherapy in the treatment of oncological diseases has been tested in many studies, and an increase in survival time has been achieved for many cases. Therefore, they can be promising targets for the creation of antitumor drugs, targeted therapy of tumors and as diagnostic biomarkers.The purpose of this review was to study the GAGE family of antigens, one of the CTA groups recognized by T cells. Proteins of this family, expressed in tumor cells, stimulate the development of a humoral and cellular immune response against them. It follows from this that they fully meet the requirements for targets for tumor immunotherapy. The review provides information about the structure and sequence of genes encoding proteins of the GAGE family. The question of the role of GAGE in apoptosis is considered in detail and the results of studies proving that GAGE-7C makes cells resistant to apoptosis mediated by interferon γ or Fas are presented. The results of clinical studies of the expression of GAGE group genes and proteins in various types of tumor diseases are considered and examples of the reported correlation between GAGE expression and poor prognosis in some types of cancer are given.Thus, the proteins of the GAGE group, with a detailed study, can become a possible diagnostic and prognostic marker of cancer diseases, and in the future be used to assess malignancy and monitor tumors for the selection of treatment tactics.
Tumor microenvironment biomarkers in breast cancer
Authors: Sokolov P. M. , Karaulov A. V. , Sukhanova A. V. , Nabiev I. R. 
Published: April 2023

Breast cancer is the most common malignant tumor in women. The tumor structure in breast cancer is characterized not only by morphological heterogeneity of tumor cells, but also by a high degree of heterogeneity of tumor microenvironment, which contains immune cells, cell matrix elements, and other components that may have procarcinogenic or anticarcinogenic effects. Therefore, personalized approaches to selecting the most effective breast cancer treatment protocols cannot be used without comprehensive analysis of the target cancer markers and cellular microenvironment biomarkers.This review is aimed at systematizing the data on tumor microenvironment biomarkers and evaluating the prognostic value of the analysis of tumor microenvironment biomarkers in breast cancer.Biomarkers of the tumor microenvironment are important prognostic factors. Molecular genetic analysis of the profile of these biomarkers, as well as immunohistochemical studies of the mutual arrangement of tumor cells and tumor microenvironment can be used for high-accuracy cancer diagnosis and for the selection of effective personalized therapy in breast cancer. This comprehensive research is necessary because of the plasticity of tumor microenvironment cells, which can either support tumor growth, block immune response, and provide resistance to drugs, or exhibit antitumor activity.The key elements of the tumor microenvironment in breast cancer have been analyzed, and examples of interaction between tumor cells and the microenvironment, as well as data on the prognostic and diagnostic values of tumor microenvironment biomarkers, have been summarized. The tumor microenvironment has been shown to affect the formation of drug resistance and the efficiencies of various breast cancer therapies.
Anemia syndrome associated with malignant neoplasms in patients with colorectal cancer
Authors: Blindar V. N. , Dobrovolskaya M. M. , Zubrikhina G. N. , Davydova T. V. 
Published: April 2023

Background. Colorectal cancer is the most commonly diagnosed cancer among all malignant neoplasms. This disease is accompanied by the development of anemic syndrome (AS). This complication not only worsens the results of treatment and, as a result, reduces overall survival, but also reduces the quality of life of patients, reduces adherence to treatment.Aim. To study the expression of hepcidin 25 (HP25), prohepcidin (PROHP), ferritin (FR), interleukin 6 (IL-6) and metabolites of nitric oxide (NOx) in the peripheral blood of patients colorectal cancer, to assess their relationship with the clinical course of the disease and with AS.Materials and methods. The study was conducted in 41 patients with colorectal cancer and AS. The content of FR, PROHP, HP25, IL-6 was determined using enzyme immunoassay. The total content of NOx in blood serum was determined using the Griess reagent after the reduction of nitrate to nitrite with cadmium granules in the presence of zinc.Results. There are three types of AS. A characteristic feature of which was microcytosis (MCV – 74.3 ± 2.1 fl) and hypochromia (MHC – 22.9 ± 1.2 pg) of erythrocytes. Type 1 of AS – iron deficiency anemia (IDA), type 2 – anemia of chronic diseases (ACD) in combination with iron deficiency erythropoiesis and type 3 – ACD with functional iron deficiency (FID). True IDA was detected in 15 (36.6 %) patients, which was classically characterized by: low concentration of FR, PROGP, GP25, IL-6 and NOx. A less significant group (9 patients, 21.9 %) had a high concentration of FR and low PROHP, GP25, IL-6, NOx, which indicated iron deficiency against the background of ACD. It differed from the first group with IDA in a significant concentration of FR, which may indicate the transition of IDA to the chronic phase of AS. Third group (17 patients, 41.5 %) – with FID – turned out to be the most numerous and characterized by a high concentration of FR (386.7 ± 41.2 ng/ml), GP25 (43.2 ± 7.1 ng/ml), PROHP (283.3 ± 18.5 ng/ml), IL-6 (24.8 ± 5.5 pg/ml), NOx (39.7 ± 5.5 µmol/l), the values were significantly higher (p <0.001) than in patients with IDA and ACD with iron deficiency erythropoiesis.Conclusion. In patients with a widespread tumor process, AS with FID is most often detected. FID was accompanied by hyperproduction of FR, IL-6, GP25, PROGP and NOx. A close correlation was noted between the studied parameters with an increase in the T-stage of colorectal cancer. This may indicate the relationship of these proteins in the development of cytokine-induced anemia in cancer patients. The data obtained can be widely used to assess the state of metabolic disorders in anemia associated with malignant neoplasms for the differential diagnosis of AS variants and adequate treatment.
Crust–Uppermost Mantle Structure beneath the Caribbean Region from Seismic Ambient Noise Tomography
Authors: Moreno Toiran Bladimir , Aoudia Abdelkrim , Manu-Marfo Daniel , Kherchouche Radia , Pachhai Surya 
Published: April 2023

ABSTRACT
We present a new 3D shear velocity model for the crust–uppermost mantle structure beneath the Caribbean region from the surface down to 150 km depth. Our velocity model was derived from joint inversion of group and phase velocity dispersion data obtained from ambient noise and earthquake data. The group and phase dispersion curves estimated from ambient noise were calculated from cross correlation using up to 4 yr of continuous data. Perturbations in group and phase surfaces-wave velocities within a resolution of 1° × 1° show the relevant geotectonic units in the Caribbean plate. Plate boundaries, ocean basins, rises, rifts, and microplates are well defined by shear-wave velocity impedances. The 3D shear-wave velocity inversion along profiles shows the thickening of the crust from the ocean to continental margins. We present a new Moho interface map with depths undulating between 11 and 17 km beneath most parts of the sea and 25–45 km below the continental areas. Low-velocity zones were found in the uppermost mantle indicating a highly laterally heterogeneous area.
Multidetector computed tomography in evaluation of maxillofacial injuries
Authors: Agarwal Parul , Ramnani Deepak , Tambi Ayush 
Published: April 2023

Facial injuries occur in significant proportion in trauma patients requiring prompt diagnosis and management. The number of maxillofacial injuries is continuously increasing due to rise in traffic, failure to take preventive measures in the traffic leads to road traffic accidents, which is the main etiological factor in maxillofacial fractures. To study role of multidetector tomography in evaluation of maxillofacial injuries. To describe the advantages of 3D reconstructed images over axial images in the imaging of facial fractures. This cross-sectional study included 100 patients who underwent CT evaluation of facial bones when they presented with evidence of fracture of maxillofacial bones on a 64-slice volume scanner (SIEMENS SOMATOM definition) in Geetanjali Medical College and Hospital, Udaipur during February 2019 to July 2020. RTA comprised of 76.19% cases. Assault and fall from height were 11.42 and 12.38%. The maxilla, the walls of its sinus were the most commonly involved bone with 71.42% next was Naso-orbito-ethmoid 68.57%. Zygomatic bone and mandible fractures were 50 and 38.09%. The type 2 frontal bone fractures were commonly seen 12 (31.5%) followed by Type 3, 10 (26.02%), Type 4 & Type 1 seen in 6 (15.7%) and Type 5 was the least common injury seen 4 (10.52%). The medial wall of the orbit was most commonly involved 49 (35.76%). Le Fort fracture lines were identified in 17 occasions with Le Fort II seen 9 (52.9%). The advantages of 3D images within the assessment of facial trauma might be described especially in mandible and cheekbone. 3D images were better within the identification of Le Fort fracture lines. The coronal reconstructed images are superior in the detection of fractures in the orbit and maxilla. 3D images have a limited role in fractures involving the naso-orbito-ethmoid region and also when there is minimal fracture displacement.
A Comparative Study of Nasal Fiberoptic Intubation with Laryngeal Mask Airway Fiberoptic Intubation in Children with a Difficult Airway
Authors: Mahdavi Alireza , Shafa Amir , Razavi Seyed Sajjad , Eghbali Ahmad , Chavoshi Tahereh 
Published: April 2023

Background: Considering that the gold standard for intubation in children with a difficult airway is the use of fiberoptic bronchoscopy, and few studies have evaluated its application in children, the present study aimed at comparing two bronchoscopic techniques of nasal fiberoptic tracheal intubation (FOI-Nasal) and fiberoptic intubation via laryngeal mask airway (FOI-LMA) in children with a difficult airway.
Methods: A single-blind randomized clinical trial was performed on 40 six-month-old to six-year-old children that were divided into two groups each consisting of 20 patients. The participants were all candidates for elective surgery with clinical criteria for the anticipated difficult intubation. FOI-Nasal and FOI-LMA were performed in the first and second groups, respectively. Mean arterial pressure (MAP), heart rate (HR), and blood oxygen saturation levels (SpO2) were assessed and recorded before anesthesia (T1), immediately before bronchoscopy (T2), and immediately after intubation with endotracheal tube (T3). Moreover, ETCO2, the first successful insertion attempt, and the intubation time were recorded, as well.
Results: The results of the present study revealed that parameters including MAP, HR, and SpO2 at times T1, T2, and T3 were not significantly different between the two groups after adjusting for potential confounding factors (P> 0.05). However, ETCO2 in FOI-Nasal group with a mean of 38.40 ± 3.57 was significantly higher than that of the FOI-LMA group with a mean of 34.35 ± 3.15 (P = 0.001). In addition, the intubation time in the FOI-LMA group with a mean of 32.40 ± 7.45 was significantly shorter than that of the FOI-Nasal group with a mean of 51.75 ± 9.97 (P <0.001). The success rate in the first attempt in the FOI-Nasal group with the value of 70% was lower than that of the FOI-LMA group with the value of 90%; however, this difference was not statistically significant (P> 0.05).
Conclusion: According to the results of the present study, the intubation time in the FOI-LMA group was significantly shorter than that of the FOI-Nasal group. Moreover, the success rate of the first attempt in the FOI-LMA group was higher than that of the FOI-Nasal group. Therefore, it can be stated that FOI-LMA as compared to FOI-Nasal can be regarded as an easier technique, with a shorter intubation time, a higher success rate, and a greater stability of children’s hemodynamic parameters.
Evaluation of the Utility of Seminal Plasma Resistin and Leptin in Predicting Successful Surgical Sperm Retrieval in Men with Non-Obstructive Azoospermia
Authors: Kamel Amer Medhat , Zohdy Wael , GamalEl Din Sameh Fayek , Hosni Moawad Hanan , Hasan El Saedy Dina Atef , Zaki Gamal Eman Ahmed , Ragab Ahmed 
Published: April 2023

Background: The purpose of the current study was evaluation of the utility of seminal plasma (SP) resistin and leptin in predicting successful surgical sperm retrieval (SSR) in men with non-obstructive azoospermia (NOA).
Methods: This prospective comparative study was conducted in the andrology clinic of a specialized fertility center. In total, 53 NOA men as candidates for either first time micro‐testicular sperm extraction (micro-TESE) or repeat micro-TESE and 28 normozoospermic controls were included. ELISA was used for measurement of SP resistin and leptin levels in all participants. Significance level was defined as p< 0.05.
Results: The current study demonstrated a significant positive correlation between estradiol (E2) level in serum and SP resistin (r=0.342, p=0.025). Also, there was a highly significant positive correlation between SP leptin and SP resistin (r=0.568, p= 0.001). Interestingly, SP leptin was the only variable that demonstrated a significant correlation with eventful micro-TESE outcome in men who underwent micro-TESE for the first time. Finally, ROC curve showed that SP leptin level of 4.05 ng/ml predicted successful SSR in men who underwent micro-TESE for the first time with a sensitivity of 73.3% and a specificity of 75% as 11 out of 27 (41%) cases showed eventful micro-TESE at or above this cut-off level [AUC of 0.747, 95% CI, lower bound of 0.555, and upper bound of 0.939, p=0.030].
Conclusion: SP leptin can be used as a non-invasive biomarker to predict successful SSR in NOA cases undergoing first time micro-TESE, while SP resistin failed to play the same role.
Autentikasi Cepat Kopi Spesialti Arabika Java Preanger Kultivar Typica, Sigarar Utang dan Yellow Bourbon Menggunakan Spektroskopi UV dan Metode PLS-DA
Authors: Yulia Meinilwita , Ningtyas Kurnia Rimadhanti , Widodo Slamet , Suhandy Diding 
Published: April 2023

Kopi spesialti arabika dijual dengan harga lebih mahal dibandingkan dengan kopi robusta. Kopi spesialti arabika Java Preanger kultivar Typica, Sigarar Utang, dan Yellow Bourbon saat ini tersedia di pasar kopi premium dengan harga mahal dan saat ini menjadi salah satu target pemalsuan kopi. Penelitian ini bertujuan untuk mengevaluasi aplikasi metode spektroskopi UV dan metode PLS-DA (partial least squares-discriminant analysis) untuk autentikasi cepat kopi spesialti arabika Java Preanger dengan tiga kultivar berbeda. Sampel kopi bubuk spesialti arabika (Typica, Sigarar Utang, dan Yellow Bourbon) dan robusta disiapkan sebanyak total 550 sampel dengan berat 1 g untuk setiap sampel. Seluruh sampel diekstraksi dengan prosedur standar dan diencerkan dengan perbandingan 1:70 (volume/volume). Sampel kopi yang telah diencerkan kemudian diambil sebanyak 3 mL, dimasukkan ke dalam sel kuvet kuarsa, dan diambil spektranya menggunakan alat spektrometer UV-visible (Genesys UV-visible spectrometer, Thermo Fisher, Scientific, USA) di rentang panjang gelombang 190-400 nm dengan interval 1 nm. Hasil PCA spektra transformasi di panjang gelombang 250-400 nm menunjukkan tiga kultivar kopi spesialti arabika dan kopi robusta dapat dibedakan dengan jelas dan terletak di klaster yang berbeda. Namun kopi spesialti arabika Typica dan Sigarar Utang terletak di klaster yang saling berdekatan dan sebagian sampel saling bertumpuk menunjukkan kedua kultivar kopi arabika tersebut memiliki kemiripan. Hasil PLS-DA spektra transformasi di panjang gelombang 250-400 nm menunjukkan model klasifikasi yang dibangun dapat digunakan untuk klasifikasi kopi robusta dan kopi arabika dengan tiga kultivar berbeda (Typica, Sigarar Utang, dan Yellow Bourbon) dengan akurasi klasifikasi mencapai 97.8 sampai 100%. Hasil ini menunjukkan potensi penggunaan metode spektroskopi UV untuk autentikasi cepat kopi spesialti arabika Java Preanger Typica, Sigarar Utang, dan Yellow Bourbon.
Retrospective Study of Decubitus Ulcer in Hospitalized Patients
Authors: Rosmarwati Ervina , Mulianto Nurrachmat 
Published: April 2023

Background: Decubitus ulcer is an area of necrotic tissue due to compression of protrusion because of prolonged immobilization. Decubitus ulcer is complication that often occur due to prolonged bed rest. Decubitus ulcer can interfere with patient’s recovery process and prolonged hospital stay. Purpose: To investigate profile of decubitus ulcer in hospitalized patients in Dr. Moewardi General Hospital Surakarta during 2017- 2020. Methods: This descriptive retrospective study was conducted by using medical record of decubitus ulcers (ICD 10 L89.0, L89.1, L89.2, L89.3) in Dr. Moewardi General Hospital Surakarta during 1st January 2017-31st December 2020. Result: There were 375 decubitus ulcer patients, mostly aged 70 years or more (29.1%) and dominated by women (56%). Patients with decubitus ulcers often hospitalized in the regular ward (75.2%) with the longest length of stay being around 0-10 days (49.6%) and the most common comorbidities was malignancy (20.5%). Systemic antibiotic ceftriaxone was most often given to decubitus ulcer patients (21.6%). Most of the patients with decubitus ulcers had stage 2 decubitus ulcers (53.6%) with a predisposition to the affected area being the sacrum area (33%). The most frequently used therapy for decubitus ulcers was hydrogel dressing (33.9%). Conclusion: Decubitus ulcers are often found in patients over 70 years of age with comorbid malignancies. The most common diagnosis was stage 2 decubitus ulcers, predisposing to the sacral region and the most frequently used therapy was hydrogel dressing with ceftriaxone as a systemic antibiotic.