bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon
Authors: Skalidis Ioannis , Kyrilis Fotis L. , Tüting Christian , Hamdi Farzad , Träger Toni K. , Belapure Jaydeep , Hause Gerd , Fratini Marta , O’Reilly Francis J. , Heilmann Ingo , Rappsilber Juri , Kastritis Panagiotis L. 
Published: May 2023

AbstractThe oxoglutarate dehydrogenase complex (OGDHc) participates in the tricarboxylic acid cycle and, in a multi-step reaction, decarboxylates α-ketoglutarate, transfers succinyl to CoA, and reduces NAD+. Due to its pivotal role in metabolism, OGDHc enzymatic components have been studied in isolation; however, their interactions within the endogenous OGDHc remain elusive. Here, we discern the organization of a thermophilic, eukaryotic, native OGDHc in its active state. By combining biochemical, biophysical, and bioinformatic methods, we resolve its composition, 3D architecture, and molecular function at 3.35 Å resolution. We further report the high-resolution cryo-EM structure of the OGDHc core (E2o), which displays various structural adaptations. These include hydrogen bonding patterns confining interactions of OGDHc participating enzymes (E1o-E2o-E3), electrostatic tunneling that drives inter-subunit communication, and the presence of a flexible subunit (E3BPo), connecting E2o and E3. This multi-scale analysis of a succinyl-CoA-producing native cell extract provides a blueprint for structure-function studies of complex mixtures of medical and biotechnological value.
The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci
Authors: Jia Gengjie , Li Yu , Zhong Xue , Wang Kanix , Pividori Milton , Alomairy Rabab , Esposito Aniello , Ltaief Hatem , Terao Chikashi , Akiyama Masato , Matsuda Koichi , Keyes David E. , Im Hae Kyung , Gojobori Takashi , Kamatani Yoichiro , Kubo Michiaki , Cox Nancy J. , Evans James , Gao Xin , Rzhetsky Andrey 
Published: May 2023

AbstractHuman diseases are traditionally studied as singular, independent entities, limiting researchers’ capacity to view human illnesses as dependent states in a complex, homeostatic system. Here, using time-stamped clinical records of over 151 million unique Americans, we construct a disease representation as points in a continuous, high-dimensional space, where diseases with similar etiology and manifestations lie near one another. We use the UK Biobank cohort, with half a million participants, to perform a genome-wide association study of newly defined human quantitative traits reflecting individuals’ health states, corresponding to patient positions in our disease space. We discover 116 genetic associations involving 108 genetic loci and then use ten disease constellations resulting from clustering analysis of diseases in the embedding space, as well as 30 common diseases, to demonstrate that these genetic associations can be used to robustly predict various morbidities.
Erfolgreiche Therapie einer Retronychie
Authors: Golle Linda , Stadie Volker 
Published: May 2023

Zusammenfassung
Anamnese Wir berichten über einen 66-jährigen Patienten, bei dem seit ca. 9 Monaten eine schmerzhafte Schwellung der linken Großzehe mit subjektiv sistierendem Längenwachstum bestand.
Untersuchungen Zuvor hatten bakteriologische und mykologische Abstriche sowie eine MRT-Untersuchung keine richtungsweisenden Befunde erbracht und antibiotische, antiseptische und antiphlogistische Vortherapien hatten zu keiner Linderung der Beschwerden beigetragen.
Diagnose und Therapie Wir stellten aufgrund des klinischen Befundes mit gerötetem, kolbenartig aufgetriebenem Zehenendglied mit angehobenem proximalem Nagelwall die Diagnose einer Retronychie und führten eine Nagelplattenextraktion durch.
Verlauf In den über 2 Jahren andauernden Nachkontrollen zeigte sich der Patient beschwerdefrei mit erholtem Nagelwachstum.
Folgerungen Die Retronychie wird, wie im vorgestellten Fall oft fehldiagnostiziert. Die Kenntnis wegweisender klinischer und anamnestischer Parameter und der korrekten Therapieoptionen erlaubt eine rasche, kostengünstige und langfristig erfolgreiche Behandlung.
A review of
Pseudocercospora griseola
in common bean (
Phaseolus vulgaris
L.) in Africa
Authors: Aytenfsu Misganaw , Terefe Habtamu 
Published: May 2023

Abstract

Angular leaf spot (ALS), caused by the fungus
Pseudocercospora griseola
, is one of the most economically important diseases that limits the productivity of common beans.
P. griseola
has great variability which explains the large number of existing races and the complexity of genetic resistance. This review was carried out to discuss and document on the diversity of
P. griseola
in Africa
,
and the pathogenic variability of pathotypes against different bean varieties and lines. Diversified pathotypes were identified from different common bean-growing countries. About 12 pathotypes were identified from 45 isolates in Uganda. Similarly, about 44 pathotypes were characterized from 100 isolates in Kenya. Pathotypes 61:63 and 63:63 were the most aggressive identified pathotypes in different African countries. Many reports indicated that Andean isolates infect mostly Andean genotypes, while Mesoamerican isolates infect both Andean and Mesoamerican genotypes. The resistances of major commercial varieties and bean lines are breaking down and were found to be susceptible. Hence, multiple resistance breeding should be done for broken commercial varieties and bean lines using the potential identified gene source of landraces U00292, U0074, U351 and U1–9 from Uganda, genotype KKR IL05/Red 40 from Kenya and variety SER125/SER119 from Ethiopia.
Pressure and strain engineering of the structural and electronic transitions in ReS2
Authors: Ma Liang , Liu Dan , Xiao Binbin , Cao Yong , Wang Yicheng , Zhao Yipeng 
Published: May 2023

Abstract
The distinctive crystal structure and anisotropic electrical characteristics of rhenium disulfide (ReS2) have garnered growing interest. Pressure and strain engineering has been used to modulate structural and electronic transition. Here, we present a comprehensive study on the high-pressure phase transition and strain tunable electronic properties of ReS2. There occurs a structural transition from distorted-1T to distorted-1T′ at 7.5 GPa. In addition, ReS2 has opposite piezoresistive effects along the two principle axes in the plane. This study shows that pressure and strain may be used to tune the characteristics of ReS2 for future optoelectronic applications.
A digital twin based reliability assessment of Superbuck converters
Authors: Xia Qian , Yue Jiguang , Chen Jichang , Cui Zhexin , Lyu Feng 
Published: May 2023

Abstract
Addressing the challenge of assessing the reliability of ‘long-life, high-reliability’ DC/DC analog converters in submarine observation networks and space power systems, which have limited internal observation points and insufficient valid information, and initial assessment rendered unreliable with the long-term operation of the converter. This paper proposes a novel method based on digital twin (DT) technology. The method eliminates the need for measuring internal variables, and only requires the measurement of the converter’s ripple peak-to-peak. A digital twin (DT) is constructed based on the underlying mechanism, and the parameters of the operating converter are identified through the collection of ripple peak-to-peak, which are then injected into the DT for dynamic tracking of the physical entity. By obtaining internal current and voltage of the DT and utilizing the Markov model, the reliability of the converter can be assessed. This method offers real-time reliability assessment without the need for additional measurement points. To validate the effectiveness of the proposed approach, a Superbuck converter is used as an example to demonstrate the high-fidelity of the DT through isomorphic single-sample repeatability and isomorphic multiple-sample consistency experiments.
Excitonic solar cells based on van der Waals heterojunctions of Janus III–VI chalcogenide monolayers
Authors: Pan Jinghua , Wang Yu , Wang Danni , Ma Zelong , Jing Sicheng , Chen Wen , Bian Baoan , Liao Bin 
Published: May 2023

Abstract
We construct the two-dimensional (2D) excitonic solar cells based on type II vdW heterojunctions of Janus III–VI chalcogenide monolayers and investigate the performance of the device using the first principle. The calculated solar energy absorbance of In2SSe/GaInSe2 and In2SeTe/GaInSe2 heterojunctions is the order of 105 cm−1. The predicted photoelectric conversion efficiency of the In2SeTe/GaInSe2 heterojunction can reach up to 24.5%, which compares favorably with other previously studied 2D heterojunctions. The excellent performance of In2SeTe/GaInSe2 heterojunction originates from the fact that the built-in electric field at the interface of In2SeTe/GaInSe2 promote the flow of the photogenerated electrons. The results suggest that 2D Janus Group-III chalcogenide heterojunction can be a good candidate for new optoelectronic nanodevices.
Development of a novel strategy based on in-process compensation of charge leakage for static force measurement by piezoelectric force sensors
Authors: Chen Fuwen , Lin Huanbin , Li Zhongwei , Ju Bing-Feng , Chen Yuan-Liu 
Published: May 2023

Abstract
Ordinary piezoelectric force sensors are only capable of measuring dynamic forces but not static forces because of the charge leakage due to the finite resistance of piezoelectric materials and charge amplifiers. This paper presents a new strategy for in-process compensation of charge leakage for force measurement with wide spectrum from static to dynamic realized by piezoelectric force sensors. The compensation is in-process operated based on the concept of dynamic accumulation. In order to improve the measurement accuracy and long-term stability by the compensation, the zero offset generated by normalization, bias current and temperature drift are all theoretically analyzed and experimentally validated. Measurement experiments of four different types of force signals, which contain static, triangular, sinusoidal and random force signals acting on the piezoelectric force sensor, are conducted to validate the proposed strategy. In addition, the effect of different time constant of the piezoelectric sensor under different applied forces on the compensated results is analyzed. Performance tests containing accuracy, resolution, span and bandwidth have been conducted. It is validated that the proposed method has high sensitivity of sub-millinewton, long-term stability and wide spectrum from static signal to dynamic measurement capabilities, which would provide an effective and precise method for micro force measurement and control in ultra-precision machining, semiconductor industry and biomechanics fields.
Incident-side-dependent mirror based on 1D photonic crystals containing VO2 nanoparticles
Authors: Entezar Samad Roshan 
Published: May 2023

Abstract
The optical properties of an incident-side-dependent mirror based on a one-dimensional photonic crystal composed of nanocomposite layers containing vanadium dioxide nanoparticles were investigated theoretically using the transfer matrix method in the near-infrared spectral range. The influence of the incident angle and filling fraction of the vanadium dioxide nanoparticles on the reflectance and transmittance of the structure were studied. We found that the mirror is an incident-side-dependent reflector with nearly zero transmittance in the photonic bandgap regions. The incident-side-dependent properties of the mirror are more pronounced when the vanadium dioxide nanoparticles are in their metal phase. In addition, the mirror is a perfect reflector for incoming rays from one side and a perfect absorber for incoming rays from the opposite side. Such temperature-controlled and incident-dependent mirrors may find application in the design of various intelligent windows.
Global vegetation greenness interannual variability and its evolvement in recent decades
Authors: Gao Yifei , Yang Tong , Ye Ziqi , Lin Jiexin , Yan Kai , Bi Jian 
Published: May 2023

Abstract
The interannual variability (IAV) of global vegetation greenness needs careful assessment as it relates to the stability of the climate, conservation of biodiversity, sustainable ecosystem services, and global food security. Here, we investigated the spatial feature and temporal evolvement of global vegetation greenness interannual variability from 1982 to 2015 using the Global Inventory Modeling and Mapping Studies (GIMMS) Normalized Difference Vegetation Index third generation (NDVI3g) data. Generally, regions with herbaceous and short woody plants had larger IAV of vegetation greenness than those with tall woody biome types (7.9% versus 2.9%). On average, all the biomes displayed increasing IAV of vegetation greenness from 1982 to 2015, with notable increases over northern high latitudes (0.135%/year), Eastern Europe (0.037%//year), and Central Australia (0.231%/year). Croplands in China and India experienced decreasing IAV of vegetation greenness (–0.037%/year for China and –0.004%/year for India). The changing IAV of vegetation greenness had implications for climatic, environmental, and anthropogenic changes that influence vegetation dynamics. Some note-worthy factors include climate warming, the CO2 fertilization effect, agricultural practice improvement, cropland abandonment, and China’s Grain-for-Green Program.
Australians support for policy initiatives addressing unhealthy diet: a population-based study
Authors: Gupta Adyya , Raine Kim D , Moynihan Paula , Peres Marco A 
Published: May 2023

Summary
To inform public health policy implementation in Australia, our study investigated the level of public support for six policy initiatives addressing unhealthy diet. The policy initiatives included taxing soft drinks and energy drinks, taxing less healthy food and beverage purchases, zoning to restrict the supply of junk foods near schools, prohibiting advertising and promotion of less healthy food and beverages to children under the age of 16 and restricting sugar-sweetened beverages from vending machines in schools, and public places. Data from a cross-sectional population-based study for 4040 Australians aged 15+ years, were analysed. A high overall support across all policy initiatives was observed. Nearly three-quarter of public support was observed for policy initiatives targeting children (zoning to restrict the supply of junk food near schools, prohibiting advertising and promotion of less healthy food and beverages to children under the age of 16 and restricting sugars-sweetened beverages from vending machines in schools), and half of Australians supported policy initiatives of taxing soft drinks and energy drinks and taxing less healthy food and beverage purchases. Australian women and those with tertiary level of education were more likely to support public health initiatives targeting children and all policy initiatives respectively. Interestingly, young adults expressed low level of support for all policy initiatives. The study demonstrated considerable public support for policy initiatives focussed on protecting children from unhealthy diet in Australia. Framing, designing and implementing policies targeting children is potentially a good starting point for policymakers to create a health promoting food environment.
Gender recognition at the crossroads: Four models and the compass of comparative law
Authors: Osella Stefano , Rubio-Marín Ruth 
Published: May 2023

Abstract
The article explores the different constitutional developments of the right to gender recognition and discusses their potential to protect trans and nonbinary people. Focusing on a few selected jurisdictions, each incarnating a specific kind of recognition system, it also proposes a conceptual map to understand and identify the different shapes of such a right. The article argues that four types of gender recognition can be identified, each with their own characteristics, advantages, peculiarities, and set of challenges for trans and nonbinary people and for the system of gender categorization itself. In clarifying this area of law, the article contends that the very process of creation and policing of gender identities and categories represents a critical aspect of contemporary gender constitutionalism.
(008) Suggestions for Modifications to the Female Sexual Function Index to be Inclusive of All Populations – Cognitive Interviews with Sexual and Gender Minority and Heterosexual Persons
Authors: Lynch K , Austria M , Le T , Burrows Walters C , Vickers A , Long-Roche K , Atkinson T , Carlsson S 
Published: May 2023

Abstract

Introduction
Patient-reported outcome measures that were initially designed for research studies including heterosexual, partnered, educated cisgender women may have limited applicability for clinical use among Sexual and Gender Minority (SGM) patients and patients without a partner.

Objective
We aimed to conduct cognitive interviews with both SGM persons and heterosexual women to determine readability, comprehension, and applicability of questionnaire items to assess sexual function in populations with diverse sexual practices, focusing on items from the Female Sexual Function Index (FSFI), and to establish content validity of a modified measure.

Methods
We conducted four rounds of cognitive interviews with 52 participants (28 SGM, 24 heterosexual) who provided feedback on their comprehension and wording of FSFI questionnaire items and response scales. Participants made recommendations for changes to the questionnaire, which was iteratively revised between interview rounds. Two independent coders analyzed the transcripts using structural coding based on five predefined codes (i.e., satisfaction with item, specificity/language change needed, missing/suggested item, patient definitions of concepts, and confusion with item).

Results
After four rounds of cognitive interviews and revisions to the questionnaire, participants found the final version of the questionnaire acceptable and understandable, thereby reaching thematic saturation and establishing content validity of the modified FSFI. Modifications included: replacing all instances of “sexual stimulation” and “intercourse” with “sexual activity (alone or with a partner)”; broadening the definition of “vaginal penetration” beyond penile-vaginal penetration; adding skip logic to include the option “no sexual activity”. Participants identified missing concepts important to their sexual health, such as including the use of external lubricant. Heterosexual participants found the questionnaire initially refined by SGM participants to be acceptable, and offered targeted feedback including clarifying the clinical relevance of certain domains (e.g., questions about “emotional closeness”), clarifying terminology (e.g., sexually aroused (turned on) and naturally lubricated (wet)) and re-ordering domains (e.g., “pain should be asked about earlier”).

Conclusions
Feedback from direct interviews supports modifying FSFI items and further psychometric testing. This and other similar questionnaires need to be adapted to the broader clinical practice population such that all persons’ experiences are accurately reflected and assessed, ultimately assuring that sexual health needs can be met more inclusively. Further research in racially and educationally diverse populations is needed.

Disclosure
No
(022) Men with History of Depression Are More Likely to Continue Use of Antidepressants If Erectile Dysfunction is Treated with Testosterone or Phosphodiesterase-5 Inhibitors
Authors: Able C , Agrawal P , Singh S , Liao B , Srinivasan A , Gorman B , Kohn T 
Published: May 2023

Abstract

Introduction
Erectile dysfunction (ED) affects an estimated 30 million men in the United States with an estimated 82% of men with erectile dysfunction experiencing depressive symptoms. Prior literature has shown that initiation of therapy for ED is associated with a decrease in depressive symptoms; however, the rates of antidepressant continuation following initiation of erectile dysfunction has not been analyzed.

Objective
Our goal was to analyze the rate of antidepressant continuation for depression after prescribing testosterone or PDE-5 inhibitors for erectile dysfunction.

Methods
We queried the TriNetX Diamond network database, a health research network including 212 million patients, including healthcare encounters, insurance claims data, and prescription data between 2009-2021. We identified men with a diagnosis of depression (ICD-10: F32-33), 12 consecutive prior months of antidepressant prescriptions (VA Formulary: CN609), and a diagnosis of erectile dysfunction (ICD-10: N52). We then compared rates of antidepressants continuation over the following year in men who were prescribed PDE5i or testosterone for their erectile dysfunction versus men who had never been prescribed testosterone or PDE5i for their erectile dysfunction. The two cohorts were matched on age, race, and ethnicity. Rates of antidepressant discontinuation were compared with risk ratios (RR) and 95% confidence interval (95% CI).

Results
We identified 31,306 men that were prescribed a PDE-5 inhibitor without testosterone and an equal number of men that weren't prescribed testosterone nor PDE5i. We found that 54% of men receiving PDE5i continued using antidepressants after 12 months; while, 49% of men that weren't prescribed testosterone nor PDE5i continued using antidepressants (RR: 1.11, 95% CI: 1.10-1.13). We identified 4,468 patients who were prescribed testosterone without a PDE5i and an equal number of men that weren't prescribed testosterone nor PDE5i prescriptions. We found that 61% of men receiving testosterone prescriptions continued the use of antidepressants over subsequent 12 months; while 49% of men that weren't prescribed testosterone nor PDE5i continued using antidepressants (RR: 1.24, 95% CI: 1.20-1.29).

Conclusions
We conclude that patients who were prescribed PDE-5 inhibitors or testosterone were more likely to continue usage of antidepressants after 1 year despite the potential negative sexual dysfunction side effects that they may cause. The patient's psychiatric conditions and comorbidities should be considered when prescribing medications for sexual wellbeing in order to more holistically treat patients.

Disclosure
No