bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Hall MHD Simulations of Mercury's Magnetopause Dynamics and FTEs Under Different Solar Wind and IMF Conditions
Authors: Li Changkun , Jia Xianzhe , Chen Yuxi , Toth Gabor , Zhou Hongyang , Slavin James A. , Sun Weijie , Poh Gangkai 
Published: May 2023

AbstractMercury possesses a miniature but dynamic magnetosphere driven primarily by the solar wind through magnetic reconnection. A prominent feature of the dayside magnetopause reconnection that has been frequently observed is flux transfer events (FTEs), which are thought to be an important player in driving the global convection at Mercury. Using the BATSRUS Hall magnetohydrodynamics model with coupled planetary interior, we have conducted a series of global simulations to investigate the generation and characteristics of FTEs under different solar wind Alfvénic Mach numbers (MA) and interplanetary magnetic field (IMF) orientations. An automated algorithm was also developed to consistently identify FTEs and extract their key properties from the simulations. In all simulations driven by steady upstream conditions, FTEs are formed quasi‐periodically with recurrence time ranging from 2 to 9 s, and their characteristics vary in time as they evolve and interact with the surrounding plasma and magnetic field. Our statistical analysis of the simulated FTEs reveals that the key properties of FTEs, including spatial size, traveling speed and core field strength, all exhibit notable dependence on the solar wind MA and IMF orientation, and the trends identified from the simulations are generally consistent with previous MErcury Surface Space ENvironment, GEochemistry, and Ranging observations. It is also found that FTEs formed in the simulations contribute about 3%–13% of the total open flux created at the dayside magnetopause that participates in the global circulation, suggesting that FTEs indeed play an important role in driving the Dungey cycle at Mercury.
Conditions for Segregation of a Crystal‐Rich Layer Within a Convective Magma Ocean
Authors: Monteux J. , Qaddah B. , Andrault D. 
Published: May 2023

AbstractThe vigor of the thermal convection in a terrestrial magma ocean tends to prevent the sedimentation of the solid grains. Understanding of the overall dynamical behavior of this solid phase segregation is required to anticipate the solidification mechanisms in the early Earth mantle. We develop numerical models to monitor the crystal fraction evolution of a convecting magmatic reservoir. Our models show that the ability of the crystal fraction to disperse or sediment within the domain strongly depends on the crystal size, the density difference and the magma viscosity. Our models show that the critical value of the convection/buoyancy stress ratio separating sedimentation/suspension regimes can be smaller than 0.1. Hence, during the early crystallization of a magma ocean, suspension should be the dominant process. We then investigate the possibility of bridgmanite segregation by comparing the density difference between the MO and the solid crystals for different compositions and the critical density contrast above which crystal segregation is likely to occur. We define the relevant set of parameters; including the P‐V‐T equations of state of coexisting melt and bridgmanite in the mushy MO. We observe that bridgmanite grains are unlikely to segregate in a mantle of pyrolite composition. However, bridgmanite segregation is more likely to occur at the bottom of a MO enriched in SiO2, compared to pyrolite. When a solidifying layer contains 60% of bridgmanite and 40% of melt, we observe a significant SiO2 enrichment with increasing mantle depth in a primitive mantle compatible with seismic and geochemical observations.
Uncovering temperature-dependent exciton-polariton relaxation mechanisms in hybrid organic-inorganic perovskites
Authors: Laitz Madeleine , Kaplan Alexander E. K. , Deschamps Jude , Barotov Ulugbek , Proppe Andrew H. , García-Benito Inés , Osherov Anna , Grancini Giulia , deQuilettes Dane W. , Nelson Keith A. , Bawendi Moungi G. , Bulović Vladimir 
Published: April 2023

AbstractHybrid perovskites have emerged as a promising material candidate for exciton-polariton (polariton) optoelectronics. Thermodynamically, low-threshold Bose-Einstein condensation requires efficient scattering to the polariton energy dispersion minimum, and many applications demand precise control of polariton interactions. Thus far, the primary mechanisms by which polaritons relax in perovskites remains unclear. In this work, we perform temperature-dependent measurements of polaritons in low-dimensional perovskite wedged microcavities achieving a Rabi splitting of $${{{\hslash }}\Omega }_{{Rabi}}$$

ℏ
Ω

R
a
b
i

= 260 ± 5 meV. We change the Hopfield coefficients by moving the optical excitation along the cavity wedge and thus tune the strength of the primary polariton relaxation mechanisms in this material. We observe the polariton bottleneck regime and show that it can be overcome by harnessing the interplay between the different excitonic species whose corresponding dynamics are modified by strong coupling. This work provides an understanding of polariton relaxation in perovskites benefiting from efficient, material-specific relaxation pathways and intracavity pumping schemes from thermally brightened excitonic species.
Van der Waals nanomesh electronics on arbitrary surfaces
Authors: Meng You , Li Xiaocui , Kang Xiaolin , Li Wanpeng , Wang Wei , Lai Zhengxun , Wang Weijun , Quan Quan , Bu Xiuming , Yip SenPo , Xie Pengshan , Chen Dong , Li Dengji , Wang Fei , Yeung Chi-Fung , Lan Changyong , Liu Chuntai , Shen Lifan , Lu Yang , Chen Furong , Wong Chun-Yuen , Ho Johnny C. 
Published: April 2023

AbstractChemical bonds, including covalent and ionic bonds, endow semiconductors with stable electronic configurations but also impose constraints on their synthesis and lattice-mismatched heteroepitaxy. Here, the unique multi-scale van der Waals (vdWs) interactions are explored in one-dimensional tellurium (Te) systems to overcome these restrictions, enabled by the vdWs bonds between Te atomic chains and the spontaneous misfit relaxation at quasi-vdWs interfaces. Wafer-scale Te vdWs nanomeshes composed of self-welding Te nanowires are laterally vapor grown on arbitrary surfaces at a low temperature of 100 °C, bringing greater integration freedoms for enhanced device functionality and broad applicability. The prepared Te vdWs nanomeshes can be patterned at the microscale and exhibit high field-effect hole mobility of 145 cm2/Vs, ultrafast photoresponse below 3 μs in paper-based infrared photodetectors, as well as controllable electronic structure in mixed-dimensional heterojunctions. All these device metrics of Te vdWs nanomesh electronics are promising to meet emerging technological demands.
Automated design of protein-binding riboswitches for sensing human biomarkers in a cell-free expression system
Authors: Vezeau Grace E. , Gadila Lipika R. , Salis Howard M. 
Published: April 2023

AbstractCell-free genetically encoded biosensors have been developed to detect small molecules and nucleic acids, but they have yet to be reliably engineered to detect proteins. Here we develop an automated platform to convert protein-binding RNA aptamers into riboswitch sensors that operate within low-cost cell-free assays. We demonstrate the platform by engineering 35 protein-sensing riboswitches for human monomeric C-reactive protein, human interleukin-32γ, and phage MS2 coat protein. The riboswitch sensors regulate output expression levels by up to 16-fold with input protein concentrations within the human serum range. We identify two distinct mechanisms governing riboswitch-mediated regulation of translation rates and leverage computational analysis to refine the protein-binding aptamer regions, improving design accuracy. Overall, we expand the cell-free sensor toolbox and demonstrate how computational design is used to develop protein-sensing riboswitches with future applications as low-cost medical diagnostics.
RNA-mediated demixing transition of low-density condensates
Authors: Kim Taehyun , Yoo Jaeyoon , Do Sungho , Hwang Dong Soo , Park YongKeun , Shin Yongdae 
Published: April 2023

AbstractBiomolecular condensates play a key role in organizing cellular reactions by concentrating a specific set of biomolecules. However, whether condensate formation is accompanied by an increase in the total mass concentration within condensates or by the demixing of already highly crowded intracellular components remains elusive. Here, using refractive index imaging, we quantify the mass density of several condensates, including nucleoli, heterochromatin, nuclear speckles, and stress granules. Surprisingly, the latter two condensates exhibit low densities with a total mass concentration similar to the surrounding cyto- or nucleoplasm. Low-density condensates display higher permeability to cellular protein probes. We find that RNA tunes the biomolecular density of condensates. Moreover, intracellular structures such as mitochondria heavily influence the way phase separation proceeds, impacting the localization, morphology, and growth of condensates. These findings favor a model where segregative phase separation driven by non-associative or repulsive molecular interactions together with RNA-mediated selective association of specific components can give rise to low-density condensates in the crowded cellular environment.
Laboratory earthquakes decipher control and stability of rupture speeds
Authors: Dong Peng , Xia Kaiwen , Xu Ying , Elsworth Derek , Ampuero Jean-Paul 
Published: April 2023

AbstractEarthquakes are destructive natural hazards with damage capacity dictated by rupture speeds. Traditional dynamic rupture models predict that earthquake ruptures gradually accelerate to the Rayleigh wave speed with some of them further jumping to stable supershear speeds above the Eshelby speed (~$$\sqrt{2}$$2times S wave speed). However, the 2018Mw7.5 Palu earthquake, among several others, significantly challenges such a viewpoint. Here we generate spontaneous shear ruptures on laboratory faults to confirm that ruptures can indeed attain steady subRayleigh or supershear propagation speeds immediately following nucleation. A self-similar analysis of dynamic rupture confirms our observation, leading to a simple model where the rupture speed is uniquely dependent on a driving load. Our results reproduce and explain a number of enigmatic field observations on earthquake speeds, including the existence of stable subEshelby supershear ruptures, early onset of supershear ruptures, and the correlation between the rupture speed and the driving load.
Less is more: Antibiotics at the beginning of life
Authors: Stocker Martin , Klingenberg Claus , Navér Lars , Nordberg Viveka , Berardi Alberto , el Helou Salhab , Fusch Gerhard , Bliss Joseph M. , Lehnick Dirk , Dimopoulou Varvara , Guerina Nicholas , Seliga-Siwecka Joanna , Maton Pierre , Lagae Donatienne , Mari Judit , Janota Jan , Agyeman Philipp K. A. , Pfister Riccardo , Latorre Giuseppe , Maffei Gianfranco , Laforgia Nichola , Mózes Enikő , Størdal Ketil , Strunk Tobias , Giannoni Eric 
Published: April 2023

AbstractAntibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise (a random scatter) affect the decision-making process. In this perspective, we advocate for a factual approach quantifying the burden of treatment in relation to the burden of disease balancing antimicrobial stewardship and effective sepsis management.
Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice
Authors: Yang Soo Hyun , Yang Esther , Lee Jaekwang , Kim Jin Yong , Yoo Hyeijung , Park Hyung Sun , Jung Jin Taek , Lee Dongmin , Chun Sungkun , Jo Yong Sang , Pyeon Gyeong Hee , Park Jae-Yong , Lee Hyun Woo , Kim Hyun 
Published: April 2023

AbstractStress management is necessary for vertebrate survival. Chronic stress drives depression by excitation of the lateral habenula (LHb), which silences dopaminergic neurons in the ventral tegmental area (VTA) via GABAergic neuronal projection from the rostromedial tegmental nucleus (RMTg). However, the effect of acute stress on this LHb-RMTg-VTA pathway is not clearly understood. Here, we used fluorescent in situ hybridisation and in vivo electrophysiology in mice to show that LHb aromatic l-amino acid decarboxylase-expressing neurons (D-neurons) are activated by acute stressors and suppress RMTg GABAergic neurons via trace aminergic signalling, thus activating VTA dopaminergic neurons. We show that the LHb regulates RMTg GABAergic neurons biphasically under acute stress. This study, carried out on male mice, has elucidated a molecular mechanism in the efferent LHb-RMTg-VTA pathway whereby trace aminergic signalling enables the brain to manage acute stress by preventing the hypoactivity of VTA dopaminergic neurons.
Bioinspired artificial spider silk photocatalyst for the high-efficiency capture and inactivation of bacteria aerosols
Authors: Peng Linghui , Wang Haiyu , Li Guiying , Liang Zhishu , Zhang Weiping , Zhao Weina , An Taicheng 
Published: April 2023

AbstractBioaerosol can cause the spread of disease, and therefore, capture and inactivation of bioaerosols is desirable. However, filtration systems can easily become blocked, and are often unable to inactivate the bioaerosol once it is captured. Herein, we reported a bioinspired artificial spider silk (ASS) photocatalyst, consisting of a periodic spindle structure of TiO2 on nylon fiber that can efficiently capture and concentrate airborne bacteria, followed by photocatalytic inactivation in situ, without a power-supply exhaust system. The ASS photocatalyst exhibits a higher capture capacity than the nylon fiber substrate and a photocatalytic inactivation efficiency of 99.99% obtained under 4 h irradiation. We found that the capture capacity of the ASS photocatalyst can be mainly attributed to the synergistic effects of hydrophilicity, Laplace pressure differences caused by the size of the spindle knots and surface energy gradients induced by surface roughness. The bacteria captured by the ASS photocatalyst are inactivated by photocatalysis within droplets or at the air/photocatalyst interfaces. This strategy paves the way for constructing materials for bioaerosol purification.
Participation bias in the UK Biobank distorts genetic associations and downstream analyses
Authors: Schoeler Tabea , Speed Doug , Porcu Eleonora , Pirastu Nicola , Pingault Jean-Baptiste , Kutalik Zoltán 
Published: April 2023

AbstractWhile volunteer-based studies such as the UK Biobank have become the cornerstone of genetic epidemiology, the participating individuals are rarely representative of their target population. To evaluate the impact of selective participation, here we derived UK Biobank participation probabilities on the basis of 14 variables harmonized across the UK Biobank and a representative sample. We then conducted weighted genome-wide association analyses on 19 traits. Comparing the output from weighted genome-wide association analyses (neffective = 94,643 to 102,215) with that from standard genome-wide association analyses (n = 263,464 to 283,749), we found that increasing representativeness led to changes in SNP effect sizes and identified novel SNP associations for 12 traits. While heritability estimates were less impacted by weighting (maximum change inh2, 5%), we found substantial discrepancies for genetic correlations (maximum change inrg, 0.31) and Mendelian randomization estimates (maximum change inβSTD, 0.15) for socio-behavioural traits. We urge the field to increase representativeness in biobank samples, especially when studying genetic correlates of behaviour, lifestyles and social outcomes.
Mass measurements show slowdown of rapid proton capture process at waiting-point nucleus 64Ge
Authors: Zhou X. , Wang M. , Zhang Y. H. , Litvinov Yu. A. , Meisel Z. , Blaum K. , Zhou X. H. , Hou S. Q. , Li K. A. , Xu H. S. , Chen R. J. , Deng H. Y. , Fu C. Y. , Ge W. W. , He J. J. , Huang W. J. , Jiao H. Y. , Li H. F. , Li J. G. , Liao T. , Litvinov S. A. , Liu M. L. , Niu Y. F. , Shuai P. , Shi J. Y. , Song Y. N. , Sun M. Z. , Wang Q. , Xing Y. M. , Xu X. , Xu F. R. , Yan X. L. , Yang J. C. , Yu Y. , Yuan Q. , Yuan Y. J. , Zeng Q. , Zhang M. , Zhang S. 
Published: May 2023

AbstractX-ray bursts are among the brightest stellar objects frequently observed in the sky by space-based telescopes. A type-I X-ray burst is understood as a violent thermonuclear explosion on the surface of a neutron star, accreting matter from a companion star in a binary system. The bursts are powered by a nuclear reaction sequence known as the rapid proton capture process (rp process), which involves hundreds of exotic neutron-deficient nuclides. At so-called waiting-point nuclides, the process stalls until a slower β+ decay enables a bypass. One of the handful of rp process waiting-point nuclides is 64Ge, which plays a decisive role in matter flow and therefore the produced X-ray flux. Here we report precision measurements of the masses of 63Ge, 64,65As and 66,67Se—the relevant nuclear masses around the waiting-point 64Ge—and use them as inputs for X-ray burst model calculations. We obtain the X-ray burst light curve to constrain the neutron-star compactness, and suggest that the distance to the X-ray burster GS 1826–24 needs to be increased by about 6.5% to match astronomical observations. The nucleosynthesis results affect the thermal structure of accreting neutron stars, which will subsequently modify the calculations of associated observables.
Usefulness of texture and color enhancement imaging (TXI) in early gastric cancer found after Helicobacter pylori eradication
Authors: Shijimaya Takuya , Tahara Tomomitsu , Uragami Tomio , Yano Narumi , Tokutomi Yutaro , Uwamori Atsushi , Nishimon Shuhei , Kobayashi Sanshiro , Matsumoto Yasushi , Nakamura Naohiro , Okazaki Takashi , Takahashi Yu , Tomiyama Takashi , Honzawa Yusuke , Fukata Norimasa , Fukui Toshiro , Naganuma Makoto 
Published: April 2023

AbstractEarly-stage gastric cancer (EGC) found after Helicobacter pylori (Hp) eradication is often difficult to diagnose using conventional white light (WL) endoscopy. We aimed to evaluate whether Texture and Color Enhancement Imaging (TXI), a new image-enhanced endoscopy enhances the EGC lesions after Hp eradication. We also compared diagnostic accuracy and lesion detection time between WL and TXI in trainee endoscopists. 58 EGC lesions after successful Hp eradication were enrolled. Using endoscopic images in WLI, TXI mode 1 (TXI1), and TXI mode 2 (TXI2), visibility of EGC was assessed by six expert endoscopists using a subjective score. Mean color differences (ΔE) of four matched adjacent and intra-tumoral points were examined. Using randomly allocated images, diagnostic accuracy and lesion detection time were evaluated in three trainee endoscopists. Visibility score was unchanged (Score 0) in 20.7% (12/58) and 45.6% (26/57), slightly improved (Score 1) in 60.3% (35/58) and 52.6% (30/57), obviously improved (Score 2) in 45.6% (26/58) and 1.8% (1/57), in TXI1 and TXI2 compared to WL, respectively. Mean ΔE ± SEM in TXI1 (22.90 ± 0.96), and TXI2 (15.32 ± 0.71) were higher than that in WL (1.88 ± 0.26, both P < 0.0001). TXI1 presented higher diagnostic accuracy compared to WL, in two of three trainees (94.8% vs. 74.1%, 100% vs. 89.7%, P = 0.003; < 0.005, respectively). Lesion detection time was shorter in TXI1 in two of three trainees (P = 0.006, 0.004, respectively) compared to WL. TXI improves visibility of EGC after Hp eradication that may contribute to correct diagnosis.
High bending strength at 1800 °C exceeding 1 GPa in TiB2-B4C composite
Authors: Kuncser A. , Vasylkiv O. , Borodianska H. , Demirskyi D. , Badica P. 
Published: April 2023

AbstractHigh density (99.5%) ceramic composite composed of titanium boride and boron carbide (70/30 vol%) was obtained by spark plasma sintering and was tested by 3-point bending test in Ar atmosphere at 1800 °C. Bending strength was high, around 1.1 GPa. The strength–strain curve presents a peculiar shape composed of three regions where elastic and plastic deformations are active with a different weight. Based on transmission electron microscopy observations we propose a process of mechanical energy absorption driven by shear stress in the boron carbide crystals: stacking faults with (1-11) and (011) stacking planes and twins with (1-11) twinning plane rearrange into nano-twins with (10-1) twinning planes, orthogonal but equivalent to the initial ones. This rearrangement mechanism provides in the first instance a plastic signature, but further contributes strengthening.
Is implant choice associated with fixation strength for displaced radial neck fracture: a network meta-analysis of biomechanical studies
Authors: Su Yu-Cheng , Wang Ying-Yu , Fang Ching-Ju , Su Wei-Ren , Kuan Fa-Chuan , Hsu Kai-Lan , Hong Chih-Kai , Yeh Min-Long , Lin Chii-Jeng , Tu Yu-Kang , Shih Chien-An 
Published: April 2023

AbstractThe multitude of fixation options for radial neck fractures, such as pins, screws, biodegradable pins and screws, locking plates, and blade plates, has led to a lack of consensus on the optimal implant choice and associated biomechanical properties. This study aims to evaluate the biomechanical strength of various fixation constructs in axial, sagittal, and torsional loading directions. We included biomechanical studies comparing different interventions, such as cross/parallel screws, nonlocking plates with or without augmented screws, fixed angle devices (T or anatomic locking plates or blade plates), and cross pins. A systematic search of MEDLINE (Ovid), Embase, Scopus, and CINAHL EBSCO databases was conducted on September 26th, 2022. Data extraction was carried out by one author and verified by another. A network meta-analysis (NMA) was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Primary outcomes encompassed axial, bending, and torsional stiffness, while the secondary outcome was bending load to failure. Effect sizes were calculated for continuous outcomes, and relative treatment ranking was measured using the surface under the cumulative ranking curve (SUCRA). Our analysis encompassed eight studies, incorporating 172 specimens. The findings indicated that fixed angle constructs, specifically the anatomic locking plate, demonstrated superior axial stiffness (mean difference [MD]: 23.59 N/mm; 95% CI 8.12–39.06) in comparison to the cross screw. Additionally, the blade plate construct excelled in bending stiffness (MD: 32.37 N/mm; 95% CI − 47.37 to 112.11) relative to the cross screw construct, while the cross-screw construct proved to be the most robust in terms of bending load failure. The parallel screw construct performed optimally in torsional stiffness (MD: 139.39 Nm/degree; 95% CI 0.79–277.98) when compared to the cross screw construct. Lastly, the nonlocking plate, locking T plate, and cross-pin constructs were found to be inferior in most respects to alternative interventions. The NMA indicated that fixed angle devices (blade plate and anatomic locking plate) and screw fixations may exhibit enhanced biomechanical strength in axial and bending directions, whereas cross screws demonstrated reduced torsional stability in comparison to parallel screws. It is imperative for clinicians to consider the application of these findings in constraining forces across various directions during early range of motion exercises, taking into account the distinct biomechanical properties of the respective implants.