bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep Quality among Undergraduate Public Medical and University Students: A Comparative Study
Authors: Md Golam Abbas  , Somaya Mostarin  , Sumaya Hossin Rimmi  , Riazin Sultana  , Showlin Hossain  , Mohammad Nurunnabi  
Published: March 2023

Background: Sleeping is the body's natural means of recharging, which aids in repair, healing, and learning from all interactions and activities during the day. To maintain their focus, concentration, and academic performance, students need to get enough sleep at night. Objective: To determine and compare the sleep quality of 278 undergraduate medical and university students. Materials and Methods: This online-based cross-sectional study was conducted by using a pre-tested semi-structured questionnaire with Pittsburgh Sleep Quality Index (PSQI) scale. Results: The mean age of medical students were 22.6±1.5 years and university students were 22.0±1.2 years. The mean study hours in a day, spending time on digital media and BMI were almost similar in both settings students. The mean PSQI scores were 7.2±3.3 in medical students and 6.4±3.3 in university students respectively. Majorities of the students (71.2% and 58.3%) had poor sleep quality, but subjective sleep quality was good in both settings of students (60.4% and 51.8%). Educational backgrounds were significantly associated with level of sleep quality, level of subjective sleep quality and mean of PSQI scores (p<0.05). Conclusion: This study demonstrates that sleep quality is poor among public medical college students compared to university students.
KYAMC Journal Vol. 13, No. 04, January 2023: 223-228
Acute Kidney Injury Is A Predictor Of Mortality In Patients Hospitalized With Covid-19
Authors: Rasul Md Maqsudur , Emran Hossain  , Miskat Joha  , Dewan Mohaimenul Haque  
Published: March 2023

Background: Common biomarkers used to determine the disease severity and prognosis of corona virus disease -19 (Covid-19) are well determined. Among these biomarkers only few can reliably predict disease outcome but they are not easily available and costly. So organ-specific functional status especially acute kidney injury (AKI) can be use as predictor of prognosis. Objective: To determine the kidney disease indicator as a marker in predicting the severe disease in COVID-19 patients. Material & Methods: We studied the health records for all purposively selected hospitalized Covid-19 patients for three months from 1st May to 31st July, 2020, at combined military hospital Dhaka, Bangladesh. Those who were more than 18 years old and hospitalized RT-PCR positive for COVID-19 patients were enrolled. Those having history of renal replacement therapy (RRT) and unwilling to participate were excluded from the study. Kidney disease significance between survivors and deceased were examined using Cox proportional hazard regression analysis. In-hospital death was ascertained by using the Kaplan-Meier method.Results: Total 470 patients were enrolled in this study. Mean age of study population was 54.7 (± 14.3) years and male to female ratio was about 2:1. Hypertension (51.91%) and diabetes mellitus (43.19%) were the most common co morbidity. During hospital stay 106 (22.55%) patients developed AKI. Total 23 (4.89%) patients were died of the total study population. Among them 19 (82.60%) had AKI. Mortality rate was significantly (P value<.001) higher among patients who developed AKI than those who did not (82.60 % vs 17.40%).Conclusion: Monitoring functional status of kidney should be given due importance to all Covid-19 patients even with mild disease. Early diagnosis and appropriate treatment of kidney injury and avoidance of nephrotoxic medications may help to reduce mortality and improve prognosis of COVID-19.
KYAMC Journal Vol. 13, No. 04, January 2023: 192-197
O impacto da COVID-19 em pacientes hipertensos e atuação multiprofissional: uma revisão integrativa
Authors: Ferreira Marceli Dias , Camilo Lúcia Aparecida Lebioda , Ranthum Larissa Knysak , Savi Alessandro Otávio Silton , Laroca Paula Renata Barbosa , Muller Erildo Vicente , Borges Pollyanna Kássia de Oliveira 
Published: March 2023

Objetivo: descrever os fatores que impactam na progressão e gravidade da infecção pelo coronavírus em pacientes hipertensos, bem como identificar ações de enfretamento que no controle dessa morbidade. Metodologia: Foi realizada uma revisão integrativa de publicações disponíveis nas bases de dados MEDLINE, LILACS e SciELO, no período de junho a julho de 2021. Os termos de busca utilizados foram: “Hypertension” AND “COVID-19” AND “Chronic Disease”. Resultados: Foram identificados e incluídos 8 artigos para a revisão. Os fatores abordados foram categorizados em três grupos de assuntos em comum: Fatores imunológicos; Terapia anti-hipertensiva e Fatores sociais e de saúde pública. Os principais impactos incluem linfocitopenias, pneumonias graves e crescimento de letalidade. Conclusão: Os pacientes hipertensos são impactados negativamente com a pandemia de COVID-19, com reações importantes e aumento de mortalidade. Entretanto, a literatura ainda apresenta divergências sobre os reais fatores que contribuem para um pior desfecho clínico.
ANALISIS FAKTOR DALAM MENILAI KUALITAS DOKUMENTASI KEPERAWATAN
Authors: WASHILAH WARDATUL , SUHARTINI TITIK 
Published: March 2023

Dokumentasi asuhan keperawatan merupakan indikator penting yang dapat mempengaruhi pemberian asuhan keperawatan. faktor yang mempengaruhi kualitas dokumentasi keperawatan diantaranya pengetahuan, motivasi, supervise usia, tingkat pendidikan, status kepegawaian dan masa kerja. Penelitian ini bertujuan untuk menilai faktor yang paling berpengaruh terhadap kualitas pendokumentasian keperawatan Penelitian ini menggunakan desain penelitian analitik korelasional dengan cross secsional. Populasinya adalah perawat di Ruang Melati RSUD Waluyo Jati Kraksaan dengan dengan menggunakan accidental sampling yang berjumlah 93 perawat. Analisa data dengan uji Fisher dan regresi logistic untuk mengetahui hubungan variabel yang paling berpengaruh terhadap kualitas dokumentasi keperawatan. Hasil penelitian diperoleh factor yang paling berpengaruh adalah beban kerja dengan pelaksanaan pendokumentasian dengan OR yaitu OR=2,1. Kesimpulan beban kerja menjadi faktor penting dalam dokumentasi keperawatan dimana mengacu pada semua kegiatan yang dilakukan oleh seorang perawat saat melayani di unit layanan keperawatan.
KEY PERFORMANCE INDICATOR BERBASIS MANAJEMEN RISIKO STUDI KASUS (PT GRC MANAGEMENT )
Authors: ANISA KRISTI  , ANTON RUBIANTO  , MARON MBROBUKI KOIBUR  , CALVIN NATHANAEL  , DEWIYANTI SANGKEK  , WIYANTI EVELINA NADEAK  , DENNY TEWU  
Published: March 2023

Abstract
This research is aimed to understand risk-based KPI at PT GRC Management. This research is designed quantitatively by performing risk assessment from the company’s KPI. Samples used are risk that directly affect the company’s target achievement. By looking at Management Business Process which in turn possesses good quality and to reach company’s target, Risk Management is necessary in promoting better capacity and quality of human resources of the company.
Keywords: KPI, Management System, Quality and Knowledge

Abstrak
Penelitian ini bertujuan untuk mengetahui KPI berbasis risiko pada PT GRC Management, Penelitian ini didesain secara kualitatif dengan melakukan assessment risiko yang berangkat dari KPI Perusahaan. Sampel yang digunakan adalah risiko-risiko yang berdampak langsung terhadap pencapaian target perusahaan. Dengan melihat Proses Bisnis Manajemen yang pada akhirnya memperoleh Kualitas Mutu yang baik dan untuk mencapai target dari perusahaan maka Knowledge Manajemen sangat diperlukan dalam peningkatan kapasitas dan kualitas Sumber daya manusia yang dimiliki oleh perusahaan

Kata Kunci: KPI, Sistem Manajemen, Mutu dan Knowledge
EGAsubmitter: A software to automate submission of nucleic acid sequencing data to the European Genome-phenome Archive
Authors: Viviani Marco , Montemurro Marilisa , Trusolino Livio , Bertotti Andrea , Urgese Gianvito , Grassi Elena 
Published: March 2023

Making raw data available to the research community is one of the pillars of Findability, Accessibility, Interoperability, and Reuse (FAIR) research. However, the submission of raw data to public databases still involves many manually operated procedures that are intrinsically time-consuming and error-prone, which raises potential reliability issues for both the data themselves and the ensuing metadata. For example, submitting sequencing data to the European Genome-phenome Archive (EGA) is estimated to take 1 month overall, and mainly relies on a web interface for metadata management that requires manual completion of forms and the upload of several comma separated values (CSV) files, which are not structured from a formal point of view. To tackle these limitations, here we present EGAsubmitter, a Snakemake-based pipeline that guides the user across all the submission steps, ranging from files encryption and upload, to metadata submission. EGASubmitter is expected to streamline the automated submission of sequencing data to EGA, minimizing user errors and ensuring higher end product fidelity.
Clinical application of functional near-infrared spectroscopy for burn assessment
Authors: Kim Yoo Hwan , Paik Seung-Ho , Kim Youngmin , Yoon Jaechul , Cho Yong Suk , Kym Dohern , Hur Jun , Chun Wook , Kim Beop-Min , Kim Byung-Jo 
Published: March 2023

Significance: Early assessment of local tissue oxygen saturation is essential for clinicians to determine the burn wound severity.Background: We assessed the burn extent and depth in the skin of the extremities using a custom-built 36-channel functional near-infrared spectroscopy system in patients with burns.Methods: A total of nine patients with burns were analyzed in this study. All second-degree burns were categorized as superficial, intermediate, and deep burns; non-burned skin on the burned side; and healthy skin on the contralateral non-burned side. Hemodynamic tissue signals from functional near-infrared spectroscopy attached to the burn site were measured during fNIRS using a blood pressure cuff. A nerve conduction study was conducted to check for nerve damage.Results: All second-degree burns were categorized into superficial, intermediate, and deep burns; non-burned skin on the burned side and healthy skin on the contralateral non-burned side showed a significant difference distinguishable using functional near-infrared spectroscopy. Hemodynamic measurements using functional near-infrared spectroscopy were more consistent with the diagnosis of burns 1 week later than that of the degree of burns diagnosed visually at the time of admission.Conclusion: Functional near-infrared spectroscopy may help with the early judgment of burn extent and depth by reflecting differences in the oxygen saturation levels in the skin.
Fe/MOF based platform for NIR laser induced efficient PDT/PTT of cancer
Authors: Liang Zixing , Li Xiaofeng , Chen Xiaofang , Zhou Jiawei , Li Yanan , Peng Jianhui , Lin Zhousheng , Liu Gai , Zeng Xiancheng , Li Cheng , Hang Lifeng , Li Hailiang 
Published: March 2023

Introduction: Photodynamic therapy (PDT) and photothermal therapy (PTT) are widely used in the treatment of tumors. However, their application in the treatment of clinical tumors is limited by the complexity and irreversible hypoxia environment generated by tumor tissues. To overcome this limitation, a nanoparticle composed of indocyanine green (ICG) and Fe-MOF-5 was developed.Methods: We prepared F-I@FM5 and measured its morphology, particle size, and stability. Its enzyme like ability and optical effect was verified. Then we used MTT, staining and flow cytometry to evaluated the anti-tumor effect on EMT-6 cells in vitro. Finally, the anti-tumor effect in vivo has been studied on EMT-6 tumor bearing mice.Results: For the composite nanoparticle, we confirmed that Fe-MOF-5 has the best nanozyme activity. In addition, it has excellent photothermal conversion efficiency and generates reactive oxygen species (ROS) under near-infrared light irradiation (808 nm). The composite nanoparticle showed good tumor inhibition effect in vitro and in vivo, which was superior to the free ICG or Fe-MOF-5 alone. Besides, there was no obvious cytotoxicity in major organs within the effective therapeutic concentration.Discussion: Fe-MOF-5 has the function of simulating catalase, which can promote the decomposition of excessive H2O2 in the tumor microenvironment and produce oxygen to improve the hypoxic environment. The improvement of tumor hypoxia can enhance the efficacy of PDT and PTT. This research not only provides an efficient and stable anti-tumor nano platform, but also has broad application prospects in the field of tumor therapy, and provides a new idea for the application of MOF as an important carrier material in the field of photodynamic therapy.
Physician-modified fenestration or in situ fenestration for preservation of isolated left vertebral artery in thoracic endovascular aortic repair
Authors: Shen Peier , Li Donglin , Wu Ziheng , He Yangyan , Wang Xiaohui , Shang Tao , Zhu Qianqian , Tian Lu , Li Zhenjiang , Zhang Hongkun 
Published: March 2023

ObjectiveTo present our experience of preserving the isolated left vertebral artery (ILVA) with physician-modified fenestration (PM-F) or in situ fenestration (ISF) during thoracic endovascular aortic repair (TEVAR) for aortic pathologies involving aortic arch.MethodsThis is a single-center, retrospective, observational cohort study. Between June 2016 and December 2021, 9 patients (8 men; median age 60.0 years old) underwent TEVAR with ILVA reconstruction (PM-F, n = 6; ISF, n = 3) were identified and analyzed.ResultsThe technical success rate was 100%. No early (&lt;30 days) death occurred. No aortic rupture, major stroke or spinal cord injury was observed. The median follow up was 38.0 (rang: 1.0–66.0) months. One death occurred at 56 months, while the reason cannot be identified. No aortic rupture, major stroke or spinal cord injury was observed during follow up. No patient required reintervention. Out of the 22 successfully revascularized target vessels, 2 ILVAs were found occluded in 2 patients at 6 months and 7 months, respectively. However, these two patients were asymptomatic.ConclusionsOur initial experience reveals that PM-F or ISF for ILVA preservation was feasible, safe, and effective during TEVAR for complex thoracic aortic pathologies. However, the patency of preserved ILVA should be improved.
Effects of assisted reproductive technology on gene expression in heart and spleen tissues of adult offspring mouse
Authors: Chen Huanhuan , Zhang Lei , Yue Feng , Cui Chenchen , Li Yan , Zhang Qingwen , Liang Linlin , Meng Li , Zhang Cuilian 
Published: March 2023

ObjectivesAssisted reproductive technology (ART) is an important part of reproductive medicine, whose possible effects on offspring’s health have drawn widespread attention in recent years. However, relevant studies are limited to postnatal short-term follow-up and lack of diverse sample sources analysis other than blood.MethodsIn this study, a mouse model was used to explore the effects of ART on fetal development and gene expression in the organs of offspring in the adulthood using next-generation sequencing. The sequencing results were then analyzed.ResultsThe results showed that it caused abnormal expression in 1060 genes and 179 genes in the heart and spleen, respectively. Differentially expressed genes (DEGs) in the heart are mainly enriched in RNA synthesis and processing, and the cardiovascular system development also shows enrichment. STRING analysis identified Ccl2, Ptgs2, Rock1, Mapk14, Agt, and Wnt5a as the core interacting factors. DEGs in the spleen are significantly enriched in anti-infection and immune responses, which include the core factors Fos, Jun and Il1r2. Further exploration revealed the abnormal expression of 42 and 5 epigenetic modifiers in the heart and spleen, respectively. The expression of the imprinted genes Dhcr7, Igf2, Mest and Smoc1 decreased in the hearts of ART offspring, and the DNA methylation levels of Igf2- and Mest-imprinting control regions (ICRs) increased abnormally.ConclusionIn the mouse model, ART can interfere with the gene expression pattern in the heart and spleen of the adult offspring and that these changes are related to the aberrant expression of epigenetic regulators.
Gender bias in fetal malformations: A cross-sectional study in Asian populations
Authors: Zhang Meixiang , Su Yingchun , Sun Ying-pu 
Published: March 2023

ObjectivesThe aim of this study was to detect any gender bias in fetal malformation cases.DesignThis study was a cross-sectional, quantitative survey.SubjectsOverall, 1,661 Asian fetal malformation cases involving induced abortions in the obstetrics department of the first Affiliated Hospital of Zhengzhou University from 2012 to 2021 were included.Main outcome measuresMeasurements of ultrasound detectable structural malformations were classified into 13 subtypes. Karyotyping, single nucleotide polymorphism (SNP) array, or sequencing diagnosis of these fetus was also included in the outcome measures.ResultsThe sex ratio (male/female) of all malformation types was 1.446. Cardiopulmonary had the highest proportion of all malformation types with 28%. Diaphragmatic hernia, omphalocele, gastroschisis, nuchal translucency (NT), and Multy malformations had significantly higher proportions of males (p &lt; 0.05). Digestive system malformations had a significantly higher proportion of females (p &lt; 0.05). Maternal age was associated with genetic factors (r = 0.953, p &lt; 0.001) and inversely associated with brain malformations (r = −0.570, p = 0.002). More males were found with trisomy 21, trisomy 18, and monogenetic diseases, while duplications, deletions, and uniparental disomy (UPD) had similar sex ratios between males and females, but not statistically significant.ConclusionSex differences are common with fetal malformations, with higher proportions of males. Genetic testing has been proposed to account for these differences.
Association of atopic dermatitis with autoimmune diseases: A bidirectional and multivariable two-sample mendelian randomization study
Authors: Zhou Weixin , Cai Jie , Li Zifan , Lin Ying 
Published: March 2023

BackgroundObservational studies have suggested the association between atopic dermatitis (AD) and the risks of autoimmune diseases. It is still unclear, however, whether or in which direction causal relationships exist, because these associations could be confounded.ObjectivesOur study seeks to assess the possibility of AD as a cause of autoimmune diseases, and to estimate the magnitude of the causal effect.MethodsTwo-sample mendelian randomization (MR) analyses were performed using genome-wide association study (GWAS) summary-level statistics. Specifically, bidirectional MR analyses were conducted to examine the direction of association of AD with autoimmune diseases; multivariable MR analyses (MVMR1) were used to test the independence of causal association of AD with autoimmune diseases after controlling other atopic disorders (asthma and allergic rhinitis), while MVMR2 analyses were conducted to account for potential confounding factors such as smoking, drinking, and obesity. Genetic instruments for AD (Ncases=22 474) were from the latest GWAS meta-analysis. The GWAS summary data for asthma and allergic rhinitis were obtained from UK Biobank. The GWAS summary data for smoking, alcohol consumption, obesity and autoimmune diseases (alopecia areata, vitiligo, systemic lupus erythematosus, ankylosing spondylitis, rheumatoid arthritis, and type 1 diabetes) were selected from the largest GWASs available. Causal estimates were derived by the inverse-variance weighted method and verified through a series of sensitivity analyses.ResultsGenetically predicted AD linked to higher risks of rheumatoid arthritis (OR, 1.28; P=0.0068) (ORMVMR1, 1.65; P=0.0020) (ORMVMR2, 1.36; P&lt;0.001), type 1 diabetes (OR, 1.37; P=0.0084) (ORMVMR1, 1.42; P=0.0155) (ORMVMR2, 1.45; P=0.002), and alopecia areata (OR, 1.98; P=0.0059) (ORMVMR1, 2.55; P&lt;0.001) (ORMVMR2, 1.99; P=0.003) in both univariable and multivariable MR. These causal relationships were supported by sensitivity analyses. No causal effect of AD was identified in relation to systemic lupus erythematosus, vitiligo, and ankylosing spondylitis. Concerning the reverse directions, no significant association was noted.ConclusionThe results of this MR study provide evidence to support the idea that AD causes a greater risk of rheumatoid arthritis, type 1 diabetes and alopecia areata. Further replication in larger samples is needed to validate our findings, and experimental studies are needed to explore the underlying mechanisms of these causal effects.
LRPPRC facilitates tumor progression and immune evasion through upregulation of m6A modification of PD-L1 mRNA in hepatocellular carcinoma
Authors: Wang Houhong , Tang Amao , Cui Yayun , Gong Huihui , Li Heng 
Published: March 2023

ObjectiveLRPPRC is a newly discovered N6-methyladenosine (m6A) modification reader, which potentially affects hepatocellular carcinoma (HCC) progression. PD-L1 in tumor cells is essential for tumor immune evasion. This work investigated the LRPPRC-mediated m6A-modification effect on PD-L1 mRNA and immune escape in HCC.MethodsExpression and clinical implication of LRPPRC and PD-L1 were measured in human HCC cohorts. The influence of LRPPRC on malignant behaviors of HCC cells was investigated through in vitro assays and xenograft tumor murine models. The posttranscriptional mechanism of LRPPRC on PD-L1 and anti-tumor immunity was elucidated in HCC cells via RIP, MeRIP−qPCR, RNA stability, immunohistochemical staining, and so forth.ResultsLRPPRC exhibited the notable upregulated in human HCC tissues, which was in relation to advanced stage and worse overall survival and disease-free survival. Impaired proliferative capacity and G2/M phage arrest were found in LRPPRC-knockout cells, with increased apoptotic level, and attenuated migratory and invasive abilities. In HCC patients and murine models, LRPPRC presented a positive interaction with PD-L1, with negative associations with CD8+, and CD4+ T-cell infiltrations and chemokines CXCL9, and CXCL10. LRPPRC loss downregulated the expression of PD-L1 and its m6A level in HCC cells. Moreover, LRPPRC suppression mitigated tumor growth in murine models and improved anti-tumor immunity and immune infiltration in tumors.ConclusionThis work unveiled that LRPPRC may posttranscriptionally upregulate PD-L1 partially with an m6A-dependent manner for heightening mRNA stabilization of PD-L1 and provided a new mechanism for m6A regulator-mediated immunosuppression in HCC.