bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between mental health and stressors among fathers of children with chronic illnesses and cognitive structure of fathers’ stress experiences
Authors: HARAGUCHI Masahiro 
Published: February 2023

Abstract

Background: To clarify the relationship between stressor and mental health of the fathers with children with chronic illnesses and to examine the cognitive structure of fathers’ stress experiences.Methods: A self-reported questionnaire survey was conducted on 137 respondents. The dependent variables were the stressors of the fathers and depression. Focusing on the data of 51 fathers of children with chronic illness, for 21 items related to the stressful experiences had been identified in a previous study, an exploratory factor analysis using the principal factor method was performed.Findings: Logistic regression analysis results showed that the items “There are children with chronic illness” and “The large number of medical treatments required for the children” were significantly associated with the fathers’ poor mental health. In the factor analysis, the following three factors were extracted as a recognition of the fathers’ stress experiences. The fathers positively recognized their role as a father and a husband, perceiving it in a positive light despite their negative feelings.Discussion: The mental health of fathers of children with chronic illnesses while being exposed to stressors in daily life should be maintained. The positive psychology approach theory, nursing support and maintaining the father's mental health might be useful.
A structural model of the iRhom-ADAM17 sheddase complex reveals functional insights into its trafficking and activity
Authors: Kahveci-Türköz Selcan , Bläsius Katharina , Wozniak Justyna , Rinkens Cindy , Seifert Anke , Kasparek Petr , Ohm Henrike , Oltzen Shixin , Nieszporek Martin , Schwarz Nicole , Babendreyer Aaron , Preisinger Christian , Sedlacek Radislav , Ludwig Andreas , Düsterhöft Stefan 
Published: February 2023

Abstract
Several membrane-anchored signal mediators such as cytokines (e.g., TNFα) and growth factors are proteolytically shed from the cell surface by the metalloproteinase ADAM17, which thus has an essential role in inflammatory and developmental processes. The membrane proteins iRhom1 and iRhom2 are instrumental for the transport of ADAM17 to the cell surface and its regulation. However, the structure-function determinants of the iRhom-ADAM17 complex are poorly understood. We used AI-based modelling to gain insights into the structure-function relationship of this complex. We identified different regions in the iRhom homology domain (IRHD) that are differentially responsible for iRhom functions. We have supported the validity of the predicted structure-function determinants with several in vitro, ex vivo and in vivo approaches and demonstrated the regulatory role of the IRHD for iRhom-ADAM17 complex cohesion and forward trafficking. Overall, we provide mechanistic insights into the iRhom-ADAM17-mediated shedding event, which is at the centre of several important cytokine and growth factor pathways.
Capturing effects of blood flow on the transplanted decellularized nephron with intravital microscopy
Authors: Corridon Peter R. 
Published: February 2023

Abstract
Organ decellularization creates cell-free, collagen-based extracellular matrices that can be used as scaffolds for tissue engineering applications. This technique has recently gained much attention, yet adequate scaffold repopulation and implantation remain a challenge. Specifically, there still needs to be a greater understanding of scaffold responses post-transplantation and ways we can improve scaffold durability to withstand the in vivo environment. Recent studies have outlined vascular events that limit organ decellularization/recellularization scaffold viability for long-term transplantation. However, these insights have relied on in vitro/in vivo approaches that need enhanced spatial and temporal resolutions to investigate such issues at the microvascular level. This study uses intravital microscopy to gain instant feedback on their structure, function, and deformation dynamics. Thus, the objective of this study was to capture the effects of in vivo blood flow on the decellularized glomerulus, peritubular capillaries, and tubules after autologous and allogeneic orthotopic transplantation into rats. Large molecular weight dextran molecules label the vasculature. They revealed substantial degrees of translocation from glomerular and peritubular capillary tracks to the decellularized tubular epithelium and lumen as early as 12 hours after transplantation, providing real-time evidence of the increases in microvascular permeability. Macromolecular extravasation persisted for a week, during which the decellularized microarchitecture was significantly and comparably compromised and thrombosed in both autologous and allogeneic approaches. These results indicate that in vivo multiphoton microscopy is a powerful approach for studying scaffold viability and identifying ways to promote scaffold longevity and vasculogenesis in bioartificial organs.
Comparing arthropod communities on two types of extensive green roofs
Authors: Dijck Thomas , Janssen Marc , Stassen Eugène , Vankerkhoven François , Mechelen Carmen , Beenaerts Natalie , Jacobs Jeffrey , Artois Tom 
Published: February 2023

Abstract
Extensive green roofs are said to increase local arthropod diversity in urban environments. Most roofs are dominated by either generalists or xerothermic species, as a result of their isolated locations and shallow substrate layers. We investigated whether biodiverse extensive green roofs (Sedum spp., forbs and grasses) attract more arthropod species than conventional extensive green roofs (only Sedum spp.) and differ in their respective community compositions. Six conventional and six biodiverse green roofs were sampled continuously for one year via pitfall traps. Ants, carabids and spiders were identified to the species level. We found 63 spider species, 47 ground beetle species and 22 ant species during our study. Spider communities were dominated by easily dispersible species of Linyphiidae, ground beetle communities by either eurytopic or xerothermic species, and ant communities by the synanthrope Lasius niger. While ant communities differed significantly between conventional and biodiverse roofs, no effect of roof type was observed for spider or ground beetle communities. We conclude that both types of green roof give similar results in the context of conserving urban arthropod diversity, at least for the taxa we investigated. In order to attract a wider variety of arthropods in urban areas we recommend the installation of green roofs that are specifically designed to increase biodiversity.
"Wow!" and "Aah": Bimodal Stimuli of Affective States with High and Low Intensity Displays
Authors: Binter Jakub , Prossinger Hermann , Hladký Tomáš , Boschetti Silvia 
Published: February 2023

Abstract
Our study focused on the ability of humans to correctly rate the valence of human facial expressions and vocalizations of high (pain and pleasure) and low intensity (laugh and neutral expression/speech) affective states. The study was conducted online and used a large sample (n=902) of respondents. The task was to categorize whether the human vocalization and facial expression as positive, neutral, or negative. The stimuli were audio records and pictures of facial expressions extracted from freely downloadable online videos and can be considered semi-naturalistic. Each rating participant was presented simultaneously with the facial expression and the vocalization of the affective states. Two of these with high intensity (pain and pleasure) and two of low intensity (laugh/smile and neutral). Each affective state was expressed and rated by female and male expressers. Using a Bayesian statistical approach, we could test due-to-chance probabilities (guessing). The outcomes support the prediction that affective states with higher intensity are harder to correctly rate, even with a bimodal presentation. Furthermore, in comparison with previous unimodal studies using the same stimuli, the results provide novel insight into systematic perception. Adding the vocalizations to the facial expressions results in the participants being more convinced in their choices independently of the correctness of the assessment as previously shown in auditory stimuli perception.
Optimal motility strategies for self-propelled agents to explore porous media
Authors: Lohrmann Christoph , Holm Christian 
Published: February 2023

Abstract
Micro-robots for, e.g., biomedical applications, need to be equipped with motility strategies that enable them to navigate through complex environments. Inspired by biological microorganisms we investigate motility patterns such as run-and-reverse, run-and-tumble or run-reverse-flick applied to active rod-like particles in silico. We investigate their capability to efficiently explore disordered porous environments with various porosities and mean pore sizes ranging down to the scale of the active particle. By calculating the effective diffusivity for the different patterns, we can predict the optimal one for each porous sample geometry. We find that providing the agent with the ability to sense position for a certain time and to make a decision based on its observation yields a motility pattern outperforming the biologically inspired patterns for all investigated porous samples.
Eribulin inhibits growth of cutaneous squamous cell carcinoma cell lines and a novel patient-derived xenograft
Authors: Hsu Che-Yuan , Yanagi Teruki , Maeda Takuya , Nishihara Hiroshi , Miyamoto Kodai , Kitamura Shinya , Ujiie Hideyuki 
Published: February 2023

Abstract
Advanced cutaneous squamous cell carcinoma (cSCC) is treated with chemotherapy and/or radiotherapy, but these typically fail to achieve satisfactory clinical outcomes. There have been no preclinical studies to evaluate the effectiveness of eribulin against cSCC. Here, we examine the effects of eribulin using cSCC cell lines and a novel cSCC patient-derived xenograft (PDX) model. In the cSCC cell lines (A431 and DJM-1 cells), eribulin was found to inhibit tumor cell proliferation in vitro as assessed by cell ATP levels. DNA content analysis by fluorescence-activated cell sorting (FACS) showed that eribulin induced G2/M cell cycle arrest and apoptosis. In xenograft models of cSCC cell lines, the administration of eribulin suppressed tumor growth in vivo. We also developed a cSCC patient-derived xenograft (PDX) which reproduces the histological and genetic characteristics of a primary tumor. Pathogenic mutations in TP53 and ARID2 were detected in the patient’s metastatic tumor and in the PDX tumor. The cSCC-PDX responded well to the administration of eribulin and cisplatin. In conclusion, the present study shows the promising antineoplastic effects of eribulin in cSCC. Also, we established a novel cSCC-PDX model that preserves the patient’s tumor. This PDX could assist researchers who are exploring innovative therapies for cSCC.
Radiofrequency energy in the treatment of erectile dysfunction – a novel cohort pilot study on safety, applicability, and short-term efficacy
Authors: Gruenwald Ilan , Appel Boaz , Shechter Arik , Greestein Alexander 
Published: February 2023

Abstract
Collagen is an essential component of the structures involved in the erectile mechanism and as such, impaired collagen may hinder it. Because Radiofrequency (RF) energy has been shown to renew and restore spatial structural arrangement of collagen fibers, treatment of ED with RF could lead to anatomical and physiological changes at the penile tissue level and could lead to improvement in the erectile mechanism. We conducted this study to assess the effect of RF treatment on erection quality. We evaluated the safety, applicability, and efficacy of a self-applied, handheld, low-intensity radiofrequency device (Vertica®) in men with moderate and mild-to-moderate organic ED. The treatment protocol consisted of 12 treatments (twice a week during the 1st month, and once a week during the 2nd month), each participant treated himself individually. Treatment outcomes were evaluated using the International Index of Erectile Function (IIEF-15), Erection Hardness Scale (EHS), Erectile Dysfunction Index of Treatment Satisfaction (EDITS), Benefit, Satisfaction & Willingness to continue (BSW), Quality of Erection Questionnaire (QEQ), Sexual Quality of Life (SQOL) questionnaires and specific questions addressing side-effects and ease of use. Twenty-eight out of 32 men (mean age 59.5.7 ± 9.8, range: 41-78y) completed a one-month follow-up after treatment. Mean IIEF-15 (43.7. ±7.8 vs 60.9 ± 10.8, p < 0.01), IIEF-Erection Function domain (IIEF-EF) (16.8 ± 3.1 vs. 24.4 ± 4.4, p < 0.001), and EHS scores (2.2 ± 0.8 vs. 3.2 ± 0.5, p = 0.01) were all significantly improved. Fifty percent of patients achieved normal EF parameters (IIEF-EF score ≥ 25). High mean scores were achieved in the EDITS (76.8 ± 20.3), BSW (4.83 ± 1.1), QEQ (73.4 ± 23.8), and SQOL (67 ± 29.4) questionnaires. No side effects were reported and participants rated the device as very comfortable, simple, and easy to operate.
Characteristics and Outcomes of Children, Adolescents and Young Adults with Relapsed/Refractory Non-Hodgkin Lymphoma Undergoing Autologous Stem Cell Transplant
Authors: Nieto Yago , Pasvolsky Oren , Bassett Roland , Ghanem Sassine , Cuglievan Branko , Tewari Priti , HOSING CHITRA , Sr Samer , Ramdial Jeremy , Mahadeo Kris , Khazal Sajad , Petropoulos Demetrios , Popat Uday , Qazilbash Muzaffar , Kebriaei Partow , Champlin Richard , Shpall Elizabeth 
Published: February 2023

AbstractThere is paucity of data regarding outcomes of children, adolescents and young adults (CAYA) patients with non-Hodgkin lymphoma (NHL) undergoing autologous hematopoietic stem cell transplantation (ASCT). We analyzed 222 patients aged 0–39 years undergoing first ASCT for NHL between 2000 and 2020. The most common histological subtypes were DLBCL (44%), T-NHL (19%) and PMBCL (19%). Younger patients (age ≤ 25) had lower incidence of DLBCL and higher incidence of PMBCL and T-NHL compared to older patients (> 25 years) (P = 0.02). None of the younger patients had DH)/DE DLBCL, as compared to 14 patients in the older group (18%, P = 0.07). Younger patients had numerically better 15-year post-transplant PFS (67% vs. 54%) and OS (71% vs. 62%) compared to older patients, without statistically significant differences (P = 0.19 and P = 0.24, respectively). In MVA, not achieving a CR prior to ASCT was independently predictive of worse PFS (P < 0.0001). DH/DE status was an independent adverse predictor of PFS in MVA (HR 5.8, p = 0.03). 10 patients(4.5%) (all aged > 25 years) developed SPM Patients aged ≤ 25 years presented a distinct NHL histology as compared to older CAYA patients. Disease status at ASCT was predictive of both PFS and OS. DH/DE status was an adverse predictor of PFS.
Effectiveness of different disinfectants and combinations against SARS-CoV-2 nucleic acid in COVID-19 quarantine wards
Authors: Zhang Ying , Zhou Jianguo , Zhu Haitao , Lu Chunmei , Ye Lan , Chunyu Lingfeng , Lu Guoping , Wang Chuanqing , Fu Pan , Zhou Wenhao 
Published: February 2023

Abstract
Background
To detect the contamination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the surroundings of coronavirus disease 2019 (COVID-19) patients and to evaluate the effectiveness of regular disinfectants and combinations against SARS-CoV-2 RNA.
Methods
We sampled the patients’ high contact surfaces in COVID-19 pediatric quarantine wards from April to June 2022. After conducting cleaning procedures using disinfectants, including trichloroisocyanuric acid (TCCA; 500, 1000, and 2000 mg/L), 5% hydrogen peroxide (H2O2), 0.5% povidone-iodine (PI), 75% ethanol (EA), 0.2% chlorhexidine gluconate (CHG), 0.2% quaternary ammonia compound (QAC), and five combinations, environmental samples in bathroom were collected at 0, 30 s, 10, 30, and 60 min. All samples were delivered to the medical laboratory for SARS-CoV-2 nucleic acid (ORF1ab and N) detection using real-time PCR.
Results
SARS-CoV-2 RNA was largely detected on surfaces in the COVID-19 quarantine ward and was highest in the floor, bathroom, and bed sheet. The ORF1ab and N genes remained detectable after 60 min of treatment with QAC, PI, EA, and CHG. H2O2 and TCCA2000 completely degraded SARS-CoV-2 RNA in 30 s, which was faster than TCCA1000 (10 min). Clearance of ORF1ab and N by TCCA500 required 10 and 60 min, respectively, whereas combination of TCCA500 with EA or PI destroyed ORF1ab and N faster at 30 s and 30 min, respectively.
Conclusion
The surroundings of patients with COVID-19 are contaminated by SARS-CoV-2 RNA. Effectiveness of disinfectants and combinations varies, N gene persists longer time than ORF1ab after some disinfection.
Geophysical characteristics of active submarine sand waves off the coast of Dongfang, Hainan Island
Authors: Li Yonghang , Wen Mingming , Ni Yugen , Wan Peng , Chen Zongheng , Li Bin , Chen Zhijian , Zhao Zhenqiang , Wei Chengfu , LI Ruikeng 
Published: February 2023

Abstract
A large number of sand waves are developed on the seafloor off the coast of Dongfang, Hainan Island. This paper analyzes the geophysical characteristics of active submarine sand waves synthetically by using multi-beam echo-sounding(MBES), side-scan sonar(SSS), sub-bottom profiler (SBP), and single-channel seismic(SCS) data, and discusses the distribution characteristics, migration mechanism, activity, and morphologic evolution characteristics of sand waves. The results show and confirm that there are significant spatial differences in the distribution and scale of submarine sand waves, large and medium-sized sand waves mainly develop on the sand ridge, small sand waves mainly develop on both sides of the sand ridge, and near-symmetrical sand waves develop in the pit and trough area. Submarine sand waves were not developed in the southwest of the study area. Constrained by tidal current and Coriolis force, the migration direction of the sand wave on the west side of the submarine sand ridge is mainly north (slightly east), while that on the east side is mainly south (slightly west). Due to the topography, the migration of near-symmetric sand waves may stop or the migration direction has changed. The signatures of strong active submarine sand waves mainly include: (a) Asymmetric "ridge tip trough gentle" shape; (b) Superimposed small sand waves and sand ripples development on submarine sand waves; (c)Sub-bottom profile has transparent layer; (d)Reflection on the steep slope is blank; (e) Internal oblique progradation configuration. The analysis shows that the activity of the sand wave is closely related to its morphology, including three evolution stages low activity, high activity, and motionless.
Is there a Correlation between the Coaptation and Regeneration of Tendon Stumps in Endoscopic Assisted Achilles Tendon Rupture Repair?
Authors: Wu Helin , Dong Jingxian , Li Qing , Zheng Boyu , Wei Shijun , Kong Changwang , Xu Feng , Hou Wenguang 
Published: February 2023

Abstract
Background

Direct stitch of the ruptured site is very difficult to perform due to the frayed tendon stumps when endoscopic Achilles tendon repair technique is utilized. There is little known about whether undesirable coaptation of the tendon stumps affect the regeneration of tendons.

Methods

A retrospective analysis of 46 patients who underwent a modified endoscopic Achilles tendon rupture repair from October 2018 to June 2020. Patients were divided into 2 groups according to the coaptation of tendon stumps on postoperative ultrasonography. 17 cases in group 1 with undesirable coaptation(<50%) and 29 cases in group 2 with appropriate coaptation(≥ 50%). Magnetic resonance imaging (MRI) was obtained at postoperative 3, 6 and 12 months to evaluate the tendon morphological construction. Clinical evaluations were performed using the American Orthopedic Foot and Ankle Society (AOFAS) ankle-hind foot score, Achilles Tendon Total Rupture Score (ATRS), muscle power, and Achilles tendon resting angle at the final follow-up. Complications were also encountered.

Results

The mean follow-up time was 37.5 ± 10.6 months in group 1 and 39.0 ± 11.6 months in group 2, respectively. The average age in group 1 is slightly older than that of group 2 (37.3 ± 6.1 vs 32.7 ± 6.3, P = 0.021). The tendon cross-section areas and thickness increased initially and decreased later on postoperative MRI evaluation. It also showed a significant higher signal/noise quotient (SNQ) in group 1 at postoperative 3 months. At postoperative 6 and 12 months, the SNQ between both groups was similar. The AOFAS score (95.9 ± 5.1 vs 96.2 ± 4.9, P = 0.832), ATRS score (97.0 ± 3.6 vs 97.7 ± 3.3, P = 0.527), and muscle power (21.38 vs 24.74, P = 0.287) were not significantly different between both groups. However, the resting angle of group 1 was significantly larger than that of group 2 (4.6 ± 2.4 vs 2.4 ± 2.3, P = 0.004). There was no difference in the complications (P = 0.628).

Conclusions

There is no obvious correlation between coaptation and regeneration of tendon stumps when endoscopic Achilles tendon repair technique is applied. However, older patients could possibly have a separation of tendon stumps, resulting in an elongation of the tendon.
Applying Adaptive Super-Twisting Controller for Voltage Regulation in a DC Micro Grid
Authors: Ashtary Mahdi , Hakimi Seyed Mahdi , Naghavi Seyed Vahid , Behnamgol Vahid 
Published: February 2023

Abstract
Micro grids mainly operate in two modes of on-grid and off-grid. The main problems regarding off-gird are voltage and frequency oscillation or instability. In this case, a control system must be used to adjust the voltage and frequency of the micro grid. According to nonlinear features, uncertainty parameters and variations of the load, applying nonlinear and robust methods will be a suitable approach for the system. In this paper, a nonlinear adaptive super-twisting controller based on the sliding mode theory is used to control the micro grid. The principal reason for utilizing this controller is to control distortion in presence of parameters uncertainty. For this purpose, system dynamic equations will be extracted. Afterwards, by using sliding mode theory, a controller will be designed to control the entire system. To address chattering problem, an adaptive super-twisting method is proposed. Closed loop stability has been proved by Lyapunov theorem. The proposed method is evaluated by MATLAB/Simulink software, and a comparison between the simulation results and the other methods has been made. The comparison studies show that the proposed adaptive Super-Twisting controller is more applicable than conventional methods.