bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and risk factors during ascent to Hoh Xil and the physiological responses before and after acclimatization: a cross-sectional study
Authors: Ouyang Qing , Yang Yuting , Zou Dongbo , Peng Yuping , Zhang Wenxin , Yang Yongjian , Ma Yuan 
Published: September 2023

Abstract
Background
Ascending to altitudes > 2,500 meters may lead to acute mountain sickness (AMS). This study determines the incidence, symptoms and risk factors of AMS, anthropometric data before and after hypoxia acclimatization, and the effect of oxygen therapy in a cohort of travelers to Hoh Xil (4,200 meters).
Method
This study considered 104 healthy Chinese people, data on their demographics, height, weight, body mass index (BMI), smoking and drinking status were collected in Chengdu (500 meters). Heart rate (HR), saturation of pulse oxygen (SpO2), and AMS-related symptoms were collected in Hoh Xil (4,200 meters). Participants with headache and a score ≥ 3 was considered to have AMS.
Results
The incidence of AMS was 60.58%. AMS group had a lower SpO2 (84.67% vs. 90.66%, p<0.001) and higher HR (96.16 vs. 87.39 bp/min, p<0.001) than non-AMS group. Drinking seemed a risk factor for AMS. However, there was no difference in the BMI, age, height, weight, and smoking between AMS and non-AMS groups. The most common AMS symptom was headache, followed by dyspnea, insomnia, dizziness, lassitude, and anorexia. Women were prone to suffer from dizziness (p<0.001). The value of SpO2 and HR were improved both in AMS and non-AMS groups after hypoxia acclimatization (p<0.001), and the value showed greater improvement in AMS group (p<0.001). Oxygen therapy decreased the AMS-induced tachycardia (p = 0.018), which had no any effect on SpO2 and symptom alleviating time.
Conclusions
Lower SpO2 value and higher HR value were associated with increased risk for AMS. The anthropometric data of non-AMS group was better than AMS group before and after hypoxia acclimatization, however, AMS group showed a bigger improvement than non-AMS group. Oxygen therapy was effective in relieving AMS-induced tachycardia, but not the SpO2 value and duration of AMS.
The efficacy and safety of Multi-loop traction device for gastric endoscopic submucosal dissection: a single center prospective study
Authors: Kitahara Gen , Kaneko Toru , Ishido Kenji , Furue Yasuaki , Wada Takuya , Watanabe Akinori , Tanabe Satoshi , Kusano Chika 
Published: September 2023

Abstract
Although gastric endoscopic submucosal dissection (ESD) is widely used, the degree of difficulty varies greatly depending on the lesion. Since the multi-loop traction device (MLTD®) has been suggested to shorten the procedure time in colorectal ESD, we examined the efficacy and safety of using the MLTD in gastric ESD. Thirty patients with gastric neoplasms were prospectively enrolled from February 2022 to December 2022, and the outcomes of ESD with the MLTD were evaluated. The primary outcomes were procedure time and dissection speed. The secondary outcomes were en bloc and R0 resection rates, MLTD attachment time, and complications of ESD with the MLTD. After excluding 1 patient, 29 patients (29 lesions) were treated by ESD with the MLTD. The median procedure time was 26 min (range, 9-210 min), and the median submucosal dissection speed was 39.9 mm2/min (12.4-102.7 mm2/min). The rate of en bloc resection was 100%, median MLTD attachment time was 3 min (1-7 min), and none of the patients showed intraoperative or postoperative perforations. Thus, gastric ESD with the MLTD showed a favorable procedure time and dissection speed and an acceptable complication rate. Hence, MLTDs may be effective for gastric ESD.
Is age discrimination a risk factor for frailty progression and frailty development among older adults? A prospective cohort analysis of the English Longitudinal Study of Ageing
Authors: Aminu Abodunrin Quadri , Torrance Nicola , Grant Aileen , Kydd Angela 
Published: September 2023

Abstract
Background:
With the increasing global burden of frailty on healthcare resources, it is important to understand the modifiable risk factors of frailty. This study examined perceived age discrimination as a potential risk factor for frailty progression and frailty development among older adults.
Methods:
Prospective cohort study using data from Waves 5 to 9 of the English Longitudinal Study of Ageing (ELSA). Data on perceived age discrimination was collected only in Wave 5 of ELSA and analysed as baseline data in this study. Frailty was defined using the Frailty Index (FI) scores (0 to 1), calculated using the multidimensional deficits (scores ≥ 0.25 were considered frail). Binomial generalised estimating equation models (GEE) were fitted in R studio using perceived age discrimination as the main predictor with age, gender, long-standing illness, cognition, socioeconomic status (SES) as covariates. Odd ratios were reported with 95% confidence intervals (CI).
Results:
A total sample of 2,385 ELSA participants were included in the analysis. 55.8% (n = 1312) were female, mean age 71.9 (SD ± 5.27) years and baseline frailty prevalence was 12.1% (n = 288). Perceived age discrimination was reported by 38.4% (n = 916) of the participants. Both frailty progression (OR 1.50, CI [1.26–1.78]) and frailty development (OR 1.39, CI [1.13–1.69]) were significantly associated with perceived age discrimination in the fully adjusted models. Age (80 + years) and long-standing illness had the strongest association with respondents’ frailty outcome; odds ratios (OR 3.67, CI [2.81–4.80]) and (OR 5.61, CI [4.55–6.92]) respectively.
Conclusion:
Perceived age discrimination significantly increased the risk of frailty progression and frailty development among ELSA participants.
Metagenomics analysis of therapeutical peats samples mined from the deposits of the “Puścizna Wielka” peat bog in Poland
Authors: Łukasz Mąka , Marta Bartosik , Mazańska Małgorzata , Szynal Tomasz , Jolanta Solecka 
Published: September 2023

Abstract
Therapeutic values of therapeutical peats have been appreciated for centuries. Although microbiological criteria for therapeutical peats used in therapies exists in Poland, this source is still “terra incognita” in terms of microbiological diversity. Many authors studying peats indicate that microorganisms inhabiting this niches possess abilities allowing their application in biotechnology and various fields of industry, economy, and medicine. The aim of this research was to explore this ecosystem and reveal microbiological potential for commercial use.
Samples of peats were collected from protected deposits of the Czarny Dunajec in Poland to perform metagenomics analysis. Moreover, for better samples characteristics, physicochemical properties were performed.
In all testes samples, the most abundant phylum was Acidobacteriota, its percentage ranged from 46.42% to 60.02%. Second the most predominant phylum was Proteobacteria, present in all samples in the range of 20.75% to 35.34%. Proteobacteriais a large group of Gram-negative bacilli and cocci. This phylum is divided into five classes, among which the OTUs of Alphaproteobacteria and Gammaproteobacteriawere identified in tested samples.
Other phyla present in each tested sample were Verrucomicrobiota (1.97% – 7.72%), Desulfobacterota (0.83% - 6.04%) and Actinobacteriota (1.97% - 3.38%).
“Puścizna Wielka” peat bog possess a great microbiological potential and can be a source of bacteria that could be used in industry or biotechnology. Many articles published over the past few years describe isolates of new species and their individual features. In next step authors plan to isolate and test strains using various media and conditions.
Thyroid hormone levels in patients with bipolar disorder: A systematic review and meta- analysis
Authors: Liu Shanshan , Chen Xiaoai , Li Xiaotao , Tian Limin 
Published: September 2023

Abstract

Purpose
To investigate the difference of serum thyroid hormone (TH) levels in bipolar disorder (BD) during different mood episodes (depression and mania) compared with healthy control (HC) and among different mood episodes.
Methods
We systematically searched the electronic databases for studies on the relationship between BD and TH levels. The random effects model and the standardized mean difference were used to combine the effect sizes.
Results
Serum T3 (standard mean difference [SMD]: -0.52, 95% confidence interval [CI]: -0.86 to -0.18, P = 0.00), FT3 (SMD: -0.55, 95%CI: -1.06 to -0.04, P = 0.04) decreased significantly in BD-depression compared with HC. Serum TSH(SMD: 0.20, 95%CI: 0.04 to 0.36, P = 0.02), FT4 (SMD: 0.42, 95%CI: 0.17 to 0.66, P = 0.00) increased significantly and T3 (SMD: −0.73, 95%CI: −1.37 to -0.08, P = 0.03) decreased significantly in BD-mania compared with HC; FT4 (SMD: 0.85, 95%CI: 0.56 to 1.13, P = 0.00) increased significantly in males; TSH (SMD: 0.49, 95%CI: 0.21 to 0.78, P = 0.00) increased significantly, T3 (SMD: -0.57, 95%CI: -0.86 to -0.29, P = 0.00) and T4 (SMD: -0.68, 95%CI: -1.34 to -0.01, P = 0.05) decreased significantly in females. Serum T3 (SMD: 0.29, 95%CI: 0.12 to 0.46, P = 0.00), FT3(SMD: 0.55, 95%CI: 0.28 to 0.81, P = 0.00) increased significantly in BD-mania than in BD-depression.
Conclusion
Serum T3 and FT3 levels decreased significantly in BD-depression compared with HC. Serum TSH, FT4 levels increased significantly and T3 level decreased significantly in BD-mania compared with HC. Serum T3, FT3 levels increased significantly in BD-mania than in BD-depression. The fascinating thing was that gender differences may affect the compensatory secretion of BD-mania anterior pituitary hormone.
Trial registration number and date of registration for prospectively registered trials No. CRD42022378530 (4 December 2022)
Proteomic analysis of signaling pathways modulated by FABP5 in macrophages
Authors: Doswell Faniya , Haley John D. , Kaczocha Martin 
Published: September 2023

Abstract

Background
While acute inflammation serves essential functions in maintaining tissue homeostasis, chronic inflammation is causally linked to many diseases. Macrophages are a major cell-type that orchestrates inflammatory processes. During inflammation, macrophages undergo polarization and activation, thereby mobilizing pro-inflammatory and anti-inflammatory transcriptional programs that regulate ensuing macrophage functions. Fatty acid binding protein 5 (FABP5) is a lipid chaperone that is highly expressed in macrophages. FABP5 deletion is implicated in driving macrophages towards an anti-inflammatory phenotype, yet the signaling pathways regulated by macrophage FABP5 have not been systematically profiled. Herein, we leveraged proteomic and phosphoproteomic approaches to characterize pathways modulated by FABP5 in M1 and M2 polarized bone marrow derived macrophages (BMDMs).
Results
Stable isotope labeling by amino acids (SILAC) based analysis of M1 and M2 polarized wild-type (WT) and FABP5 knockout (KO) BMDMs revealed numerous differentially regulated proteins and phosphoproteins. FABP5 deletion impacted several downstream pathways associated with inflammation, cytokine production, oxidative stress, and kinase activity. Kinase enrichment analysis based on phosphorylated sites revealed key kinases, including members of the GRK family, that were altered in FABP5 KO BMDMs. Reactive oxygen species (ROS) levels were elevated in M1 polarized KO macrophages, consistent with the differential protein expression profiles.
Conclusions
This study represents a comprehensive characterization of the impact of FABP5 deletion upon the proteomic and phosphoproteomic landscape of M1 and M2 polarized BMDMs. Loss of FABP5 altered multiple pathways implicated in inflammatory responses and macrophage function. This work provides a foundation for future studies seeking to investigate the therapeutic potential of FABP5 inhibition in pathophysiological states resulting from dysregulated inflammatory signaling.
Feasibility and safety of integrating mass drug administration for helminth control with seasonal malaria chemoprevention among Senegalese children: a randomized controlled, observer-blind trial
Authors: Afolabi Muhammed O. , Sow Doudou , Agbla Schadrac , Fall El Hadji Babacar , Sall Fatimata Bintou , Seck Amadou , Manga Isaac Akhénaton , Mbaye Ibrahima , Loum Mor Absa , Camara Baba , Niang Diatou , Gueye Babacar , Sene Doudou , Kane Ndéye M’backé , Diop Boubacar , Diouf Awa , Gaye Ndéye Aida , Diouf Marie Pierre , Lo Aminata Colle , Greenwood Brian , Ndiaye Jean Louis A. 
Published: September 2023

Abstract
Background
The overlap in the epidemiology of malaria and helminths has been identified as a potential area to exploit for the development of an integrated control strategy that may help to achieve elimination of malaria and helminths. We conducted a randomised, controlled, observer-blind trial to assess the feasibility and safety of combining mass drug administration (MDA) for schistosomiasis and soil transmitted helminths (STH) with seasonal malaria chemoprevention (SMC) among children living in Senegal.
Methods
Female and male children aged 1–14 years were randomised 1:1:1, to receive Vitamin A and Zinc on Day 0, followed by SMC drugs (SPAQ) on Days 1–3 (control group); or praziquantel and Vitamin A on Day 0, followed by SMC drugs on Days 1–3 (treatment group 1); or albendazole and praziquantel on Day 0, followed by SMC drugs on Days 1–3 (treatment group 2). Safety assessment was performed by collecting adverse events from all children for six subsequent days following administration of the study drugs. Pre- and post-intervention, blood samples were collected for determination of haemoglobin concentration, malaria microscopy, and PCR assays. Stool samples were analysed using Kato-Katz, Merthiolate-iodine-formalin and PCR methods. Urine filtration, PCR and Circulating Cathodic Antigen tests were also performed.
Results
From 9–22 June 2022, we randomised 627 children aged 1–14 years into the three treatment groups described above. Mild, transient vomiting was observed in 12.6% (26/206) of children in treatment group 2, in 10.6% (22/207) in group 1, and in 4.2% (9/214) in the control group (p = 0.005). Pre-intervention, the geometric mean value of P.falciparum parasite density was highest among children who received albendazole, praziquantel with SMC drugs. Post-intervention, the parasite density was highest among children who received SMC drugs only. Children who received praziquantel and SMC drugs had a lower risk of developing severe anaemia than their counterparts who received SMC drugs alone (OR = 0.81, 95% CI: 0.13-5.00, p = 0.63).
Conclusions
Integration of MDA for helminths with SMC drugs was safe and feasible among Senegalese children. These findings support further evaluation of the integrated control model.
Trial registration
The study is registered at Clinical Trial.gov NCT05354258
Cannabinoid Type 1 Receptor Antagonist Impaired Spatial Memory and Increased the Tau Gene Expression in Animal Model of the Alzheimer's disease
Authors: Tavakoli-Far Bahareh , Zeraati Maryam , Choopani Samira , Fallah Parviz , Darabi Parisa , Mazloom Roham , Bayat Gholamreza , Hosseini Marjan , Goudarzvand Mahdi 
Published: September 2023

Abstract
Alzheimer's disease is a neurodegenerative disease characterized by the accumulation of two different proteins, β-amyloid and tau. The present study aimed to scrutinize the effects of bilateral administration of the cannabinoid receptor antagonist (AM251) in the hippocampus on spatial memory and tau gene expression in an Alzheimer's disease model. β-amyloid toxin was injected bilaterally into the hippocampus of Wistar male rats to induce Alzheimer's disease, and the rats were then categorized into the control group (receiving distilled water), lesion group (receiving β-amyloid), β-amyloid + DMSO group (as antagonist solvent), and AM251 antagonist receiving groups. During the training course of the Morris water maze test, the antagonist AM251 was injected bilaterally into the hippocampus for four days at doses of 5, 25, and 100 ng. To assess the spatial memory of the animals, the distance traveled, latency time, speed of the animals, and mRNA expression of tau were analyzed. The spatial memory indices increased after the injection of β-amyloid toxin, and the AM251 antagonist relatively elevated the level of memory impairment. The evaluation of the mRNA expression of tau protein revealed an increase in its level following injection of β-amyloid toxin, but there was no significant difference between the cannabinoid antagonist and β-amyloid groups. The results of this study indicate the destructive effect of beta-amyloid toxin on spatial memory as well as the positive role of the cannabinoid system in memory formation and consolidation, although further studies are warranted in this regard.
Design and emotional responses: is there coherence between what is said and what is felt? A study using biofeedback and virtual reality
Authors: Tavares Ademario Santos , Soares Marcelo M. , Marçal Marcio A. 
Published: September 2023

Abstract

Identifying users' experience when using products is one of the major challenges for design. Analyzing users’ psychophysiological reactions to an experience using biofeedback can be more reliable than using subjective evaluations, such as structured interviews and questionnaires. Two case studies were conducted to identify emotions users actually felt and to correlate these to what they reported after using two computational systems. The first system investigated users’ emotions during training on a vehicle driving simulator and the second analyzed the emotions experienced during a car racing game, both in a Virtual Reality environment. Their opinions about their emotional state were obtained using self-report techniques (using the Geneva Emotions Wheel-GEW and Positive, and Negative Affective Schedule-PANAS questionnaires) and applying EEG (brain activity with Frontal Alpha Asymmetry Index – FAAI) and infrared thermography (facial thermograms). The training experiment presented the greater correlation between the psychophysiological and the self-report responses. Results evidenced the importance of undertaking multimodal studies in design research to determine users’ emotional experiences in a virtual reality context.
Exploring the Cause of Survival Disparities in EGFR-mutated Lung Cancer Subtypes: Unraveling Distinctive Genomic and Phenotypic Features of 19Del and L858R Mutation Subtypes
Authors: Cai Yongguang , Cai Jiayi , Lu Wei , Liang Haiyan , Chen Sixian , Chen Yongfeng , Zha Qiayi , Li Yuanyuan , Hong Shuiqiang , Zhou Suli , Lu Yuan 
Published: September 2023

Abstract
Differences in the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have been observed between lung cancer patients with 19 exon deletion (19Del) and L858R mutation. We investigate the multi-omics information from the TCGA LUAD dataset and validate it using the GEO (GSE190139, GSE147377) and MSK datasets. Somatic loss-of-function alteration of RBM10 and altered Immune infiltration profile correlated with L858R decreased survival. Meanwhile, in the L858R mutation group, 9p21.3 loss and CDKN2B methylation, increased cell cycle-related gene expression, and the enrichment in cell cycle pathways were associated with poor survival. Comprehensive genomic and phenotypic analysis of the EGFR-mutated lung cancer subtypes reveals distinctive features of each subtype, laying the groundwork for subtype-specific treatment and care options for lung cancer patients.
Thermal Stability Enhancement of Separators by Ceramic/Carboxymethyl Cellulose Nanofiber Coating
Authors: Qureshi Yusra , Jung Byung Oh , Min Young Hwan , Park Jungjae , Park Ko Un , Noh Namgyu , Chae Boknam , Shin Hui-Youn , Joo Minho , Kang Eun Seck , Yuk Jong Min 
Published: September 2023

Abstract
In the quest to develop endurable and long-lasting separators for lithium-ion batteries, recent studies have been focused on the development of polyolefins-based separators that provide good mechanical strength but undergo high expansion at elevated temperatures. In this research, we have developed carboxymethyl cellulose nanofiber/ceramic composites as a coating layer of separators. Compared to the pure ceramic-coated separator, the developed composite-coated separator exhibits excellent thermal stability up to 200°C and negligible change in electrolyte uptake performance. We have demonstrated that the combination of Al2O3 nanoparticles and carboxymethyl cellulose nanofibers can enhance thermal shrinkage properties by providing a more thermally stable structure.
Preserving Data Distribution in Sampling and Instance Selection with Renyi's Divergence
Authors: Sadoghi-Yazdi Hadi , Ashkezari-Toussi Soheila , Ramezanzadeh-Yazdi Abolfazl 
Published: September 2023

Abstract

This paper presents a novel method for sampling based on a distribution function. By leveraging Renyi's divergence criterion, a recursive formulation is directly derived from the disparity between the original and estimated distributions. The Gradient descent algorithm is employed to achieve this recursive equation, and then new samples are derived. Since this method uses the distribution of the original data, it has the ability to preserve the data distribution in the sampled dataset. In instances where the original distribution is unknown, Kernel Density Estimation is employed for estimation. Experimental results demonstrate that the proposed method effectively preserves the data distribution and prevents any alteration in the data concept while maintaining the predictability of the model over selected instances. More precisely, this method has successfully reduced the dataset size by approximately $70\%$, while the accuracy of the learning algorithm has remained unaffected.
Tree trait-mediated differences in soil moisture regimes: A comparative study of Beech, Spruce, and Larch in a drought-prone area of Central Europe
Authors: Kuželková Marta , Jačka Lukáš , Kovář Martin , Hradilek Václav , Máca Petr 
Published: September 2023

Abstract
Species-specific tree traits substantially impact precipitation partitioning, soil infiltration, retention, and overall water management. With the changing climate, the evidence of drought-induced tree mortality is increasing, indicating the need for a shift to more resilient species. Therefore, the knowledge of tree species' effect on soil-water management is needed. We used a total of 54 stations for monitoring the soil moisture regimes of silt loam soil in Central Bohemia under three common and different tree species (spruce, larch, and beech). For the dry and warm part of the year 2022, the soil moisture in winter and early spring was significantly lowered by high canopy interception and gradually depleted by early spring transpiration of evergreen spruce, where mean values were more than 15% lower than for beech. Since March, the soil moisture under spruce was already below the limit of easily available water. In contrast, the deciduous beech and larch did not show a significant decrease until the foliage emergence in early May. The beech stands showed the highest soil moisture levels, which we attributed to a more effective water recharge mechanism induced by its structural traits. This adaptive strategy is vital as soil-water storage is critical for coping with climate change. In general, the results show a distinct advantage in the water recharge ability of deciduous trees and that the selection of tree species can distinctly affect soil moisture conditions, especially during drought periods in areas characterized by tight hydrological balance.