bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radial extracorporeal shockwave therapy (rESWT) for coccydynia: a prospective study of 14 patients
Authors: Lota Kabir Singh , Malliaropoulos Nikos , Bikos Georgios , Lohrer Heinz 
Published: August 2023

Background:
Coccydynia is defined as pain in the coccyx. We investigated the effect of radial extracorporeal shockwave therapy (rESWT) in the management of coccydynia.

Methods:
In this prospective study, patients (≥18 years) diagnosed with coccydynia at a sports clinic located in Thessaloniki, Greece, were eligible for rESWT treatment when they reported a visual analogue scale (VAS) pain level ≥6. Treatment sessions were once weekly and ended when VAS pain levels decreased to ≤3. Recurrence rates were documented at 3-month and 12-month follow-ups.

Results:
Fourteen patients were treated using rESWT. The mean age and symptom duration of our cohort was 33.6±7.9 (range: 20–45) years and 9.4±8.5 (range: 3–36) months, respectively. The mean number of treatment sessions per patient was 6.4±1.6 (range: 4–8). The mean device pressure, frequency, and number of pulses was 1.2±0.1 (range: 1–1.4) bar, 5.0±0.1 (range: 5–6) Hz, and 2082±74.8 (range: 2000–2300) pulses, respectively. Treatment alleviated pain in all patients, and no recurrence of symptoms was reported during follow-up. There was a positive correlation between symptom duration and the number of treatment sessions (r=0.701, P=0.005). Pairwise comparison highlighted significant reductions in VAS pain levels between each stage of treatment (P<0.001).

Conclusion:
Our study affirms the safety and efficacy of rESWT in managing coccydynia.
Excellent Response to Full-Dose 177Lu-PSMA-617 RLT in Metastatic Castration-Resistant Prostate Cancer With Transplant Kidney
Authors: Mahdi Raza Abbas , Aggarwal Piyush , Kumar Suraj , Sood Ashwani , Paul Davinder , Mittal Bhagwant Rai 
Published: August 2023

Abstract

177Lu-PSMA radioligand therapy (RLT) has shown very encouraging results in metastatic castrate-resistant prostate cancer (mCRPC) patients with acceptable adverse events. The adverse events of RLT are mainly limited to salivary glands and kidneys. However, there is dearth of available data of RLT in transplanted kidney patients with mCRPC. Here is a case of 68-year-old mCRPC patient with history of renal transplant who underwent 4 cycles of 177Lu-PSMA-617 RLT (~7.4 GBq/cycle). Posttherapy serum creatinine and glomerular filtration rate remained stable along with excellent response and symptomatic improvement, thus demonstrating the safety of full dose of 177Lu-PSMA in renal transplant patients.
68Ga-DOTA-FAPI-04 Imaging of Bilateral Phyllodes Tumor
Authors: Alçın Göksel , Arslan Esra , Baykara Ulusan Melis , Aksoy Tamer , Ergül Nurhan , Çermik Tevfik Fikret 
Published: August 2023

AbstractWe present a case of bilateral Phyllodes tumor located in both breasts in a 41-year-old woman who was detected with increased uptake on68Ga-FAPI-04 (fibroblast activation protein inhibitor) and18F-FDG PET/CT imaging. The tumor filling up the right breast was identified as borderline Phyllodes. The tumor with mild uptake in the left breast was reported as a benign Phyllodes tumor.
Isolation of Bioactive Compounds from Low-cost Agricultural Resources and its Utilization in Daily Life.
Authors: Debnath Anirban , Das Arpita 
Published: August 2023

The ethanolic, methanolic and aqueous decoction of whole plant of Oxalis corniculate Linn was evaluated for its anti‐microbial and antioxidant properties by in vitro methods. Methanolic and ethanolic decoctions showed significant antibacterial property against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi bacterial strains. In comparison to Chloramphenicol (C30) against bacteria, ethanolic decoctions showed significant effect, among the decoctions. Nowadays though the standard soap is in a huge demand but it’s also facing major backlashes due to the presence of synthetic compounds in it, which over long use may cause harmful effects on the skin health. Therefore, the organic soaps which are made up of natural ingredients, herbs or any sort ayurvedic compound have less side effects on the human skin and are much safer than standard daily soap. The formulated therapeutic soap exhibits significant amount of reducing potential (high FRAP and TAC values) and antioxidant activity (DPPH, ABTS assay).The ethanolic, methanolic and aqueous decoction of whole plant of Oxalis corniculate Linn was evaluated for its anti‐microbial and antioxidant properties by in vitro methods. Methanolic and ethanolic decoctions showed significant antibacterial property against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi bacterial strains. In comparison to Chloramphenicol (C30) against bacteria, ethanolic decoctions showed significant effect, among the decoctions. Nowadays though the standard soap is in a huge demand but it’s also facing major backlashes due to the presence of synthetic compounds in it, which over long use may cause harmful effects on the skin health. Therefore, the organic soaps which are made up of natural ingredients, herbs or any sort ayurvedic compound have less side effects on the human skin and are much safer than standard daily soap. The formulated therapeutic soap exhibits significant amount of reducing potential (high FRAP and TAC values) and antioxidant activity (DPPH, ABTS assay).
Treatment of Shengqingtongqiao Decoction for mild cognitive impairment of white matter lesions: Study protocol for a randomized, double-blind, double-dummy, parallel controlled trial
Authors: Zhang YueChan , Han XueYi , Zhang JieQing , Wei ZiJun , Mei JiaNing , Long Xie , Zhen XiaoMin , Zhang YunYun 
Published: August 2023

AbstractBackgroundWhite matter lesions(WML) is an important cause of mild cognitive impairment(MCI). Ginkgo biloba extracts (GBTs) are widely used to treat cognitive dysfunctions. But the treatment of MCI is still limited. Shenqingtongqiao Decoction(SQTQD), as a clinical empirical formula, has received good feedback in treating MCI of WML. However, there was a lack of solid clinical research on SQTQD in treating MCI. The purpose of this study is to evaluate the efficacy of SQTQD in the MCI patients of WML.MethodsThis is a randomized, double-blind, double-dummy, parallel-controlled trial. 80 participants will be assigned to receive SQTQD granules plus GBTs mimetics or SQTQD mimetic granules plus GBTs in a 1:1 ratio. The trial will last 24 weeks, including a 12-week intervention and 12-week follow-up. The primary outcome is MoCA and AVLT. The secondary outcome is a neuropsychological battery (including MMSE, SCWT, TMT, DST, SDMT, BNT, VFT, and CDT), quality of life(BI, ADL, and FAQ scores), emotion assessment(PHQ-9, GAD-7 score), Fazekas and ARWMCs scale, and fMRI. Researchers will record any adverse events throughout the trial.DiscussionThis study will provide evidence to evaluate the efficacy and safety of SQTQD for MCI of WML compared with GBTs.The trial is registered at Chinese Clinical Trial RegistryChinese Clinical Trial Registry (Number: ChiCTR2300068552)
CLINICAL EFFICACY OF PLASMID ENCODING P62/SQSTM1 (ELENAGEN) IN COMBINATION WITH GEMCITABINE IN PATIENTS WITH PLATINUM-RESISTANT OVARIAN CANCER
Authors: Krasny Sergei , Baranau Yauheni , Polyakov Sergey , Zharkova Ekaterina , Streltsova Olga , Filimonava Aliona , Siarheyeva Volha , Kazlouskaya Sviatlana , Khorau Anton , Gabai Vladimir , Shneider Alexander 
Published: August 2023

ABSTRACTPurposeThe purpose of this clinical study is to evaluate safety and efficacy of ELENAGEN, a novel anticancer therapeutics (plasmid DNA encoding p62/SQSTM1) protein, as an adjuvant to chemotherapy with Gemcitabin (GEM) in patients with advanced platinum-resistant ovarian cancer.Patients and MethodsThis was a prospective randomized multi-center study with two arms. Gemcitabine 1000 mg/m2days 1,8 every 3 weeks) was administered in both arms: In the Chemo arm (n = 20) GEM was the only treatment, and in the ELENAGEN arm (n = 20) GEM was supplemented with ELENAGEN (2.5 mg i.m. weekly). The primary endpoint was progression-free survival (PFS), and the secondary endpoint was safety. Antitumor activity was assessed by RECIST 1.1 criteria. Safety was assessed on the basis of adverse events (AEs) and serious AEs (SAEs) according to NCI CTCAE version 5.0.ResultsTo data cut-off, the median follow-up was 13.8 months. There were no SAE -related to ELENAGEN treatment. The median progression-free survival (PFS) was 2.8 and 7.2 mo in Chemo and ELENAGEN arms respectively (p Log-Rank = 0.03). Noteworthy, at the time of cut-off, 9 patients (45%) in Elenagen arm did not progress with the longest PFS recorded so far is 24 months. Subgroup analysis of patients in both arms demonstrated high efficacy of Elenagen in the patients with worse prognosis: high pretreatment levels of CA125, progression after only one line of chemotherapy, and peritoneal effusion.ConclusionsAddition of ELENAGEN to Gemcitabine is effective in patients with ovarian cancer, including those with a worse prognosis.
A cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase interacts with begomovirus capsid proteins and modulates virus retention within its vector
Authors: Ghosh Saptarshi , Mondal Banani , Jassar Ola , Ghanim Murad , Gautam Saurabh , Srinivasan Rajagopalbabu 
Published: August 2023

AbstractBegomoviruses are whitefly-transmitted ss-DNA viruses infecting dicotyledonous plants and contribute to major economic losses to global crop production. Invasion and establishment of an aggressive species ofB. tabaci, known as the B cryptic species, has severely constrained vegetable production in the southeastern and southwestern United States. Disruption of genes/pathways critical for whitefly mediated transmission can be effective for the management of begomoviruses. In this study, yeast two hybrid (Y2H)-based screening ofB. tabacicDNA library identified a cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE4) of the whitefly as an interacting partner with capsid proteins (CPs) of old- and new-world begomoviruses. Interactions of PDE4 with begomovirus CPs were validated by GST-pull-down assays, co-immunoprecipitation, and co-immunolocalization in whitefly midgut. The PDE4 family of enzymes hydrolyze cAMP and regulate intracellular cAMP levels. This study revealed that elevation of cAMP within whitefly by chemically inhibiting or gene (PDE4) silencing resulted in increased retention and transmission of begomoviruses. Similarly, decreased cAMP levels resulted in reduced begomovirus retention. The results of this study demonstrate that whitefly mediated transmission of begomoviruses is regulated by intracellular cAMP by unknown mechanisms.ImportanceBegomoviruses, transmitted by the sweetpotato whitefly, (Bemisa tabaci Gennadius), are the causal agents of many economically important plant virus diseases. Lack of host plant resistance against begomoviruses, high whitefly abundance, and whitefly’s ability to develop insecticide resistance rapidly often renders commonly used management practice ineffective. This study demonstrates how begomovirus retention within whitefly and its transmission can be modulated by altering cAMP expression of its insect vector. Naturally occurring bio-pesticides that target insect cAMPs are known. Our findings can lead to alternative strategies for the management of begomoviruses by targeting whitefly cAMP using chemicals, botanicals, or RNAi-based insecticides.
The sterol C-24 methyltransferase encoding gene,erg6, is essential for viability ofAspergillusspecies
Authors: Xie Jinhong , Rybak Jeffrey M. , Martin-Vicente Adela , Guruceaga Xabier , Thorn Harrison I. , Nywening Ashley V. , Ge Wenbo , Parker Josie E. , Kelly Steven L. , Rogers P. David , Fortwendel Jarrod R. 
Published: August 2023

ABSTRACTErgosterol is a critical component of fungal plasma membranes. Although many currently available antifungal compounds target the ergosterol biosynthesis pathway for antifungal effect, current knowledge regarding ergosterol synthesis remains incomplete for filamentous fungal pathogens likeAspergillus fumigatus. Here, we show for the first time that the lipid droplet-associated sterol C-24 methyltransferase, Erg6, is essential forA. fumigatusviability. We further show that this essentiality extends to additionalAspergillusspecies, includingA. lentulus, A. terreus,andA. nidulans. Neither the overexpression of a putativeerg6paralog,smt1,nor the exogenous addition of ergosterol could rescueerg6deficiency. Importantly, Erg6 downregulation results in a dramatic decrease in ergosterol and accumulation in lanosterol and is further characterized by diminished sterol-rich plasma membrane domains (SRDs) at hyphal tips. Unexpectedly,erg6repressed strains demonstrate wild-type susceptibility against the ergosterol-active triazole and polyene antifungals. Finally, repressingerg6expression reduced fungal burden accumulation in a murine model of invasive aspergillosis. Taken together, our studies suggest that Erg6, which shows little homology to mammalian proteins, is potentially an attractive antifungal drug target for therapy ofAspergillusinfections.IMPORTANCEA. fumigatusis the most common pathogen that causes invasive aspergillosis, a life-threatening fungal infection with more than 300,000 cases reported annually. Available antifungals to treatAspergillus-related infection are limited to three drug classes targeting the plasma membrane (ergosterol) or the cell wall, each of which suffer from either host toxicity or rising resistance levels. As ergosta-type sterols are absent in mammalian cells but are essential for fungal viability, the ergosterol biosynthesis pathway remains an enticing target for the development of new antifungals. Although ergosterol biosynthesis has been well studied in model yeast, only a few genes have been genetically characterized inA. fumigatus. Here, we characterize Erg6, one of the fungus-specific sterol biosynthesis genes, as an essential gene inAspergillusspecies. We further providein vivoevidence of the importance of Erg6 for establishment of invasive aspergillosis. Given the importance of Erg6 in other fungal systems for growth, stress resistance, and virulence, our study suggests that development of Erg6 inhibitors may be a promising strategy for developing novel broad-spectrum antifungals.
North American Powassan virus encompasses diversein vitrophenotypes
Authors: McMinn Rebekah J. , Langsjoen Rose M. , Normandin Erica , Stampfer Samuel D. , Sabeti Pardis C. , Piantadosi Anne , Ebel Gregory D. 
Published: August 2023

AbstractPowassan virus (POWV) is a tick-borne flavivirus which has resulted in increasing human cases over the past two decades. Despite high prevalence in ticks and evidence of broad distribution in North America, fewer than 50 human cases are detected annually with evidence of undetected asymptomatic infections. Experimental studies of the relationships between POWV genetic diversity and disease potential are currently lacking. In the present study, sixteen isolates originating from 13 locations in the United States and Canada were used to assessin vitrophenotypic diversity in human neuronal cells. Broad differences in replication and cytopathic ability were observed between isolates, even amongst those in the same sublineage.In vitrophenotype was not associated with geographic or temporal location and could not be associated with specific genotypes. These results support the observation that the North American POWV population may be highly genetically and phenotypically diverse. The degree to whichin vitrophenotype reflects transmission and pathogenesis remains to be determined.
Ancient Mongolian aurochs genomes reveal sustained introgression and management in East Asia
Authors: Brunson Katherine , Witt Kelsey E. , Monge Susan , Williams Sloan , Peede David , Odsuren Davaakhuu , Bukhchuluun Dashzeveg , Cameron Asa , Szpak Paul , Amartuvshin Chunag , Honeychurch William , Wright Joshua , Pleuger Sarah , Erdene Myagmar , Tumen Dashtseveg , Rogers Leland , Khatanbaatar Dorjpurev , Batdalai Byambatseren , Galdan Ganbaatar , Janz Lisa 
Published: August 2023

AbstractSocieties in East Asia have utilized domesticated cattle for over 5000 years, but the genetic history of cattle in East Asia remains understudied. Genome-wide analyses of 23 ancient Mongolian cattle reveal that East Asian aurochs and ancient East Asian taurine cattle are closely related, but neither are closely related to any modern East Asian breeds. We observe binary variation in aurochs diet throughout the early Neolithic, and genomic evidence shows millennia of sustained male-dominated introgression. We identify a unique connection between ancient Mongolian aurochs and the European Hereford breed. These results point to the likelihood of human management of aurochs in Northeast Asia prior to and during the initial adoption of taurine cattle pastoralism.One-Sentence SummaryAncient interbreeding of East Asian aurochs and cattle suggests management, but leaves no signature in modern eastern breeds.
Validation of an antigenic site targeted by monoclonal antibodies against Puumala virus
Authors: Plyusnin Alexander , Kedari Ashwini , Rissanen Ilona , Iheozor-Ejiofor Rommel Paneth , Lundkvist Åke , Vapalahti Olli , Levanov Lev 
Published: August 2023

ABSTRACTIdentification of B-cell epitopes facilitates the development of vaccines, therapeutic antibodies and diagnostic tools. Previously, the binding site of the bank vole monoclonal antibody (mAb) 4G2 against Puumala virus (PUUV, an orthohantavirus in theHantaviridaefamily of theBunyaviralesorder) was predicted using a combination of methods, including pepscan, phage-display, and site-directed mutagenesis of vesicular stomatitis virus (VSV) particles pseudotyped with Gn and Gc glycoproteins from PUUV. These techniques led to the identification of the neutralization escape mutation F915A. To our surprise, a recent crystal structure of PUUV Gc in complex with Fab 4G2 revealed that residue F915 is distal from epitope of mAb 4G2. To clarify this issue and explore potential explanations for the inconsistency, we designed a mutagenesis experiment to probe the 4G2 epitope, with three PUUV pseudoviruses carrying amino acid changes E725A, S944F, and S946F, located within the structure-based 4G2 epitope in the Gc. These amino acid changes were able to convey neutralization escape from 4G2, and S944F and S946F also conveyed escape from neutralization by human mAb 1C9. Furthemore, our mapping of all the known neutralization evasion sites from hantaviral Gcs onto PUUV Gc revealed that over 60% of these sites reside within or close to the epitope of mAb 4G2, indicating that this region represents a crucial area targeted by neutralizing antibodies against various hantaviruses. The identification of this site of vulnerability could guide the creation of subunit vaccines against PUUV and other hantaviruses in the future.
Accounting to promote ethical tolerance: the case of the Italian prostitution model (1860)
Authors: Gatti Marco , Poli Simone 
Published: August 2023

PurposeThis paper explores the role that the control system – understood as a set of financial and non-financial mechanisms – introduced by the Ministerial Decree of 15th February 1860 played in promoting the ethical tolerance of prostitution in the Kingdom of Italy.Design/methodology/approachA qualitative research method was adopted. Specifically, this study draws on literature on accounting and deviant behaviors and on Suchman's theories of legitimation (1995) to interpret empirical evidence collected from archival primary sources as well as secondary sources.FindingsThe paper highlights how the accounting mechanisms introduced by the law were molded to limit the serious consequences of prostitution from a public health standpoint and to demonstrate that the State neither profited from prostitution nor used public money to fund it. This should have stimulated ethical tolerance of the law itself and, consequently, of the prostitution that was regulated.Originality/valueThis paper opens a new research avenue in the field of accounting history by exploring the connection between accounting and prostitution. Moreover, unlike the extant literature on accounting and deviant behaviors, this study delves into the role played by accounting mechanisms to promote ethical tolerance rather than to activate normalization processes.
Dry sliding wear behavior of additively manufactured cenosphere-filled PETG syntactic foam composites
Authors: Kumar Jitendra , Negi Sushant 
Published: August 2023

Purpose
This study aims to deal with developing composite filaments and investigating the tribological behavior of additively manufactured syntactic foam composites. The primary objective is to examine the suitability of the cenosphere (CS; 0–30 Wt.%) to develop a high-quality lightweight composite structure with improved abrasion strength.

Design/methodology/approach
CS/polyethylene terephthalate glycol (PETG) composite feedstock filaments under optimized extrusion conditions were developed, and a fused filament fabrication process was used to prepare CS-filled PETG composite structures under optimal printing conditions. Significant parameters such as CS (0–30 Wt.%), sliding speed (200–800 rpm) and typical load (10–40 N) were used to minimize the dry sliding wear rate and coefficient of friction for developed composites.

Findings
The friction coefficient and specific wear rate (SWR) are most affected by the CS weight percentage and applied load, respectively. However, nozzle temperature has the least effect on the friction coefficient and SWR. A mathematical model predicts the composite material’s SWR and coefficient of friction with 87.5% and 95.2% accuracy, respectively.

Practical implications
Because of their tailorable physical and mechanical properties, CS/PETG lightweight composite structures can be used in low-density and damage-tolerance applications.

Social implications
CS, an industrial waste material, is used to develop lightweight syntactic foam composites for advanced engineering applications.

Originality/value
CS-reinforced PETG composite filaments were developed to fabricate ultra-light composite structures through a 3D printing routine.
An analysis of Dalaman International Airport’s (LTBS) noise prediction model and assessment of its noise impact
Authors: Kafali Hasim , Güçlü İbrahim 
Published: August 2023

Purpose
In this context, this study aims to obtain information about the noise levels emitted to the environment by modeling the noise map of Dalaman Airport and correlating these noise values according to the Environmental Noise Directive (END) and World Health Organization (WHO) limits.

Design/methodology/approach
Dalaman Airport Aeronautical Information Publication and 2022 flight data from the airport were analyzed. The noise levels exposed to schools and health institutions were determined using the Cnossos–Eu calculation method.

Findings
Maximum noise levels were obtained as Lden 92.29 dB(A), Lday 85.24 dB(A), Levening 89.00 dB(A) and Lnight 85.23 dB(A) according to the noise indicators. Limit values recommended by the END and WHO according to noise indicator types and measurement results were correlated and evaluated.

Originality/value
In the noise modeling of Dalaman Airport, there has previously been no evaluation of the noise limits recommended according to END or WHO in the literature.