bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENINGKATAN KARAKTER DAN KOMPETENSI GURU PAUD DALAM IMPLEMENTASI MERDEKA BERMAIN
Authors: Budi Utami Fitria , Wulandari Sisca , Kemal Faisal , Supriyanta Jaka 
Published: April 2023

Berdasarkan hasil observasi awal yang dilakukan, masih kurangnya karakter serta kompetensi guru PAUD dalam implementasi merdeka bermain. Kegiatan ini bertujuan untuk menambah pemahaman karakter guru dan pengetahuan guru-guru PAUD dalam implementasi kurikulum merdeka bermain terutama para guru yang belum memiliki latar belakang Pendidikan sarjana PG PAUD. Metode yang digunakan dalam kegiatan ini adalah dalam bentuk sosialisasi singkat mengenai Karakter guru PAUD, Motivasi terbaik seorang pendidik, Implementasi Merdeka Bermain dan Assessment dalam Merdeka Bermain. Digunakan pendekatan Participatory Action Research (PAR) dimana peserta diberikan pemaparan materi dengan metode klasikal yaitu pemberian materi dan dilanjutkan dengan sesi tanya jawab. Peserta kegiatan yaitu para guru se-Kabupaten Tangerang. Hasil kegiatan pengabdian masyarakat yang telah dilakukan dapat disimpulkan bahwa pemahaman mitra terhadap karakter yang harus dimiliki guru dalam mengimplementasikan kurikulum merdeka bermain dapat terakomodir. Kegiatan pun berlangsung dengan baik dan lancar. Hal ini sesuai dengan hasil kuesioner kepuasan yang diberikan kepada peserta setelah selesai acara
CARACTERIZAÇÃO SOCIODEMOGRÁFICA E CLÍNICAS DOS ÓBITOS MATERNOS POR COVID-19 NUMA MATERNIDADE DE REFERÊNCIA, 2020-2021
Authors: Viana Ramos Carmen , Martins Silva Zenira , Coelho Holanda Ana Maria , Maria Rebelo Sampaio da Paz Suzana , Gomes Pereira Theonas , Vieira Batista Luiza Ivete , Lopes Moreira de Almeida Isabel Marlúcia , Cangussu Oliveira Góis Adelice , Carvalho de Sousa Amanda , Fronteira Inês 
Published: April 2023

Este estudo tem por objetivo apresentar as características sociodemográficas e clínicas dos óbitos maternos causados por covid-19, em uma maternidade de referência no Nordeste, Brasil. Foi realizado um estudo retrospectivo, do tipo série de casos, descritivo, utilizando dados do Sistema de Informações sobre Mortalidade, fichas de investigação e ficha de análise dos óbitos ocorridos entre 2020 e 2021. As variáveis foram analisadas com a estatística descritiva. Identificaram-se 24 óbitos por covid-19,22 na gravidez; em mulheres com idade mediana de 30 anos (intervalo interquartil: 25,5 – 37,0). A maioria dos óbitos ocorreu em residentes em outros municípios do Piauí (n=17), com companheiro (n=13), multíparas (n=18), fizeram consulta pré-natal (n=16), com menos de seis consultas (n=9), parto/aborto na maternidade de referência (n=23), realizado por obstetras (n=23), via de parto cesárea (n=12); internadas na unidade de terapia intensiva (n=24), não tomaram vacina contra covid-19 (24). Quanto as comorbidades e complicações, 11 eram obesas e 11 apresentaram infecções secundária a covid-19. Houve aumento de mortes maternas entre 2020 e 2021 devido a ocorrência da covid-19, principalmente, em mulheres jovens, durante a gestação e com comorbidades e complicações clínicas.
PALABRAS-CHAVE: Mortalidade Materna. Covid-19. Sistemas de Informação em Saúde. Epidemiologia Descritiva.
A importância das Marcas na Proteção Patentária
Authors: Balloussier Priscila , Santos Douglas , Islabão Genizia Islabão , Rosa Jeferson , Santos Jonas 
Published: April 2023

No mundo, as vantagens e desvantagens da implementação dos sistemas marcário e patentário vigentes são bastante conhecidas, tanto em seus aspectos sociais quanto econômicos. A Marca e a Patente são ativos de Propriedade Industrial (PI) e são utilizados estrategicamente nos mais variados tipos de mercado, de maneira a otimizar a apropriação dos lucros e recuperar os investimentos empregados. A estratégia de combinação destes ativos é bastante conhecida e difundida em determinadas áreas tecnológicas. Neste sentido, o presente estudo busca identificar as principais estratégias adotadas pela empresa brasileira Natura Cosméticos S.A., no tocante à proteção de marcas e patentes, observando suas inter-relações. Aplica-se aqui uma metodologia que analisa a evolução dos depósitos de marcas e patentes nas últimas quatro décadas, alinhada às informações de investimentos realizados no mesmo interstício temporal pela empresa. Como principal resultado, verificou-se uma crescente na mudança de patamares de proteção de PI ao longo das últimas décadas até os dias atuais, assim como um crescente investimento em inovação. Disto, infere-se que a utilização das estratégias de associação entre marcas e patentes, não apenas auxilia no investimento em inovação, como também são essenciais para garantir o destaque da empresa Natura em seu segmento de atuação.
Palavras-chave: Propriedade Intelectual. Inovação. Investimentos. Marcas. Patentes.
A proteção nacional e internacional aos deslocados ambientais no município de João Pessoa (PB)
Authors: Portela Silva Matteucci Mayra , Maria Calazans Pacheco Pacifico Andrea , Patrícia Ferreira de Vasconcelos Granja Júlia 
Published: April 2023

Enchentes, deslizamentos, secas, processos de desertificação, megaeventos, projetos de desenvolvimento, entre outros, causam conflitos e destroem o ambiente de inúmeras pessoas, forçando deslocamentos intramunicipais e culminando na necessidade de novas formas de proteção ambiental e de indivíduos dependentes deste ambiente, embora rupturas ambientais também possam ocorrer como consequência desses movimentos migratórios. Diante desse cenário, regimes internacionais precisam ser reavaliados para proteger deslocados ambientais, focando na sua vulnerabilidade no local de residência e arredores. Este artigo identifica, em João Pessoa, focos de deslocamento interno de pessoas por questões ambientais, categorizando-os a partir das causas e das consequências para o migrante, para a sociedade e para o governo, haja vista chuvas, deslizamentos e projetos de desenvolvimento, por exemplo, causarem, na localidade, destruição de vidas humanas e do ambiente local. O problema foi “até que ponto os deslocados internos ambientais de João Pessoa, PB, são migrantes forçados sujeitos à proteção internacional?”, com o fim de localizar os focos destes deslocamentos no município, suas causas e consequências, formas de proteção aos deslocados, em nível local, nacional e internacional, e propor medidas para protegê-los, com método indutivo, bibliográfico e de estudo de caso.
Palavras-chave: Proteção Internacional. Deslocados ambientais. João Pessoa (PB).
Nota Editorial
Authors: Sobreira de Moura Alexandrina 
Published: April 2023

Os artigos selecionados para esta edição da Revista Ciência & Trópico representam contribuições originais para repensar debates teóricos que marcam análises multidisciplinares e contemporâneas.
A construção do conhecimento expressa pela reflexão dos autores nesta edição da Revista Ciência & Trópico significa o compromisso de partilhar valores democráticos e difundir a cultura do diálogo e da tolerância. A missão de formar vínculos é fundamental para criar condições de “estar-juntos”. Stefan Zweig, na conferência Unidade Espiritual do Mundo, proferida no Rio de Janeiro, em 1936, expressou, com atualidade, esse pensamento: “Não são as línguas e as montanhas e os mares que separam as pessoas, mas seus preconceitos e sua desconfiança”.
Procesos de implementación de un gestor documental: caso de estudio unidad académica de administración
Authors: Calderón Curipoma Mireya Alexandra , Lugo García Jorge , Ormaza Andrade Jorge Edwin 
Published: April 2023

Uno de los objetivos que se enmarcan en la educación superior es mejorar el servicio académico y administrativo a todos sus estudiantes, docentes y funcionarios, en este sentido, implementar un sistema de gestión documental, ayuda a optimizar los procesos universitarios e implementa políticas de gestión de documentos tales como: la legitimidad, temporalidad, trazabilidad basados en entornos digitales para su posterior registro (archivo) que sirva de repositorio interactivo de edición y consulta, bajo este contexto, lo que propone este estudio es brindar desde un aspecto metodológico una guía de implementación de un gestor documental, que sirva como eje transversal para los modelos de negocio que busquen mejorar sus procesos organizacionales, la comunicación de sus clientes internos y externos y su productividad, en consecuencia, para el diseño de esta base metodológica primero se realizó el levantamiento de la situación archivística y gestión documental, posteriormente se utilizó técnicas de análisis documental y entrevista, por último, al procesar la información, se evidenciaron problemas de conservación y almacenamiento del fondo documental, demora en recuperación de documentos para consultas de usuarios internos y externos, duplicidad de información e información innecesaria, de manera que, se consideraron los diversos escenarios de la gestión documental y mediante el prototipado se establecieron las bases para la implementación total de los procesos estudiados, en conclusión, la revisión y dirección eficaz de los documentos generados y la metodología propuesta permitió el trabajo coordinado en los ámbitos académico-administrativo de la unidad académica utilizada como caso de estudio.
Treatment with levosimendan in an experimental model of early ventilator-induced diaphragmatic dysfunction
Authors: Zambelli Vanessa , Murphy Emma J. , Del Vecchio Paolo , Rizzi Laura , Fumagalli Roberto , Rezoagli Emanuele , Bellani Giacomo 
Published: April 2023

Introduction: Mechanical ventilation (MV) is a life-saving approach in critically ill patients. However, it may affect the diaphragmatic structure and function, beyond the lungs. Levosimendan is a calcium sensitizer widely used in clinics to improve cardiac contractility in acute heart failure patients. In vitro studies have demonstrated that levosimendan increased force-generating capacity of the diaphragm in chronic obstructive pulmonary disease patients. Thus the aim of this study was to evaluate the effects of levosimendan administration in an animal model of ventilator-induced diaphragmatic dysfunction (VIDD) on muscle contraction and diaphragm muscle cell viability.
Methods: Sprague-Dawley rats underwent prolonged MV (5 hours). VIDD+Levo group received a starting bolus of levosimendan immediately after intratracheal intubation and then an intravenous infusion of levosimendan throughout the study. Diaphragms were collected for ex vivo contractility measurement (with electric stimulation), histological analysis and Western blot analysis. Healthy rats were used as the control.
Results: Levosimendan treatment maintained an adequate mean arterial pressure during the entire experimental protocol, preserved levels of autophagy-related proteins (LC3BI and LC3BII) and the muscular cell diameter demonstrated by histological analysis. Levosimendan did not affect the diaphragmatic contraction or the levels of proteins involved in the protein degradation (atrogin).
Conclusions: Our data suggest that levosimendan preserves muscular cell structure (cross-sectional area) and muscle autophagy after 5 hours of MV in a rat model of VIDD. However, levosimendan did not improve diaphragm contractile efficiency.
Viewing our World through a Different Lens: Environmental and Social Considerations in International Arbitration
Authors: Greenwood Lucy 
Published: April 2023

Climate change is the greatest challenge humanity will face this century, yet the international arbitration community has been slow to recognize its significance and to react to its effects. The international arbitration community was similarly slow to address the under-representation of women in arbitration, with measurable change in this area only being seen in the last five years. We have yet to realize any significant improvement achieving a more diverse community more generally, beyond the narrow issue of the under-representation of women. This article addresses the behavioural changes which have been achieved in these areas and considers those that remain to be implemented to embed environmental and social considerations into the culture of international arbitration. It argues that every dispute should be viewed through a diversity and an environmental lens and identifies the changes that are needed now. We must secure change to ensure that arbitration meets the needs of its users, as we look to a future which looks very different to even the recent past.
Relación de edad y sobrevida tras cirugía con intención curativa por cáncer gástrico en adultos
Authors: Guerrero Barrera Karla Daly , Gallegos Maldonado Verónica Elizabeth , Bravo Muñoz Marx Ítalo 
Published: April 2023

Introducción: El cáncer gástrico constituye como una de las enfermedades de mayor morbimortalidad a nivel mundial; no obstante, la mortalidad se puede reducir con intervenciones tempranas. El objetivo del presente estudio fue determinar la relación entre la edad y la sobrevida tras cirugía con intención curativa por cáncer gástrico en pacientes atendidos en el Instituto del cáncer SOLCA, Cuenca, en el periodo 2012-2017.
Métodos: El presente estudio analítico, retrospectivo fue realizado con la base de datos del Instituto del Cáncer SOLCA-Cuenca. Los datos fueron presentados en tablas de frecuencia y porcentajes. Se aplicó Chi-cuadrado (X2), análisis de Kaplan Meier y regresión de Cox, para relacionar las variables edad y años de sobrevida, considerándose estadísticamente significativo cuando P<0.05.
Resultados: De los 603 pacientes con cáncer gástrico registrado durante el periodo de evaluación, el 35.3% fueron intervenidos quirúrgicamente, lográndose el seguimiento del 45.1%. Un total de 96 pacientes fueron incluidos, el 70.8% fueron intervenidos quirúrgicamente con intención curativa. En la muestra predominaba los hombres (52.9%) y el grupo etario de 70 a 79 años (30.2%). La tasa de sobrevida a los 5 años fue de 69.1% con un tiempo promedio de supervivencia de 7.24±0.49 años. La edad no se relacionó significativamente con la sobrevida de los pacientes (X2=3.15; P=0.667).
Conclusión: existe una elevada tasa de sobrevida a los 5 años en los pacientes con cáncer gástrico intervenidos quirúrgicamente con intención curativa, la cual no asoció con la edad.
SUMOylation patterns and signature characterize the tumor microenvironment and predict prognosis in lung adenocarcinoma
Authors: Chen Zhike , Yang Jian , Tang Lijuan , Sun Xue , Li Yu , Sheng Ziqing , Ding Hao , Xu Chun , Tong Xin , Zhao Jun 
Published: April 2023

Background: Recent studies have revealed that SUMOylation modifications are involved in various biological processes, including cancer development and progression. However, the precise role of SUMOylation in lung adenocarcinoma (LUAD), especially in the tumor immune microenvironment, is not yet clear.Methods: We identified SUMOylation patterns by unsupervised consensus clustering based on the expression of SUMOylation regulatory genes. The tumor microenvironment in lung adenocarcinoma was analyzed using algorithms such as GSVA and ssGSEA. Key genes of SUMOylation patterns were screened for developing a SUMOylation scoring model to assess immunotherapy and chemotherapy responses in lung adenocarcinoma patients. Experiments were conducted to validate the differential expression of model genes in lung adenocarcinoma. Finally, we constructed a nomogram based on the SUMOylation score to assess the prognosis of individual lung adenocarcinoma patients.Results: Two patterns of SUMOylation were identified, namely, SUMO-C1, which showed anti-tumor immune phenotype, and SUMO-C2, which showed immunosuppressive phenotype. Different genomic subtypes were also identified; subtype gene-T1 exhibited a reciprocal restriction between the immune microenvironment and stromal microenvironment. High SUMOylation scores were indicative of poor lung adenocarcinoma prognosis. SUMOylation score was remarkably negatively correlated with the infiltration of anti-tumor immune cells, and significantly positively correlated with immune cells promoting immune escape and immune suppression. In addition, patients with low scores responded better to immunotherapy. Therefore, the developed nomogram has a high prognostic predictive value.Conclusion: The SUMOylation patterns can well discriminate the tumor microenvironment features of lung adenocarcinoma, especially the immune cell infiltration status. The SUMOylation score can further assess the relationship between SUMOylation and immune cell crosstalk and has significant prognostic value and can be used to predict immunotherapy and chemotherapy response in patients with lung adenocarcinoma.
Vision transformers for the prediction of mild cognitive impairment to Alzheimer’s disease progression using mid-sagittal sMRI
Authors: Hoang Gia Minh , Kim Ue-Hwan , Kim Jae Gwan 
Published: April 2023

BackgroundAlzheimer’s disease (AD) is one of the most common causes of neurodegenerative disease affecting over 50 million people worldwide. However, most AD diagnosis occurs in the moderate to late stage, which means that the optimal time for treatment has already passed. Mild cognitive impairment (MCI) is an intermediate state between cognitively normal people and AD patients. Therefore, the accurate prediction in the conversion process of MCI to AD may allow patients to start preventive intervention to slow the progression of the disease. Nowadays, neuroimaging techniques have been developed and are used to determine AD-related structural biomarkers. Deep learning approaches have rapidly become a key methodology applied to these techniques to find biomarkers.MethodsIn this study, we aimed to investigate an MCI-to-AD prediction method using Vision Transformers (ViT) to structural magnetic resonance images (sMRI). The Alzheimer’s Disease Neuroimaging Initiative (ADNI) database containing 598 MCI subjects was used to predict MCI subjects’ progression to AD. There are three main objectives in our study: (i) to propose an MRI-based Vision Transformers approach for MCI to AD progression classification, (ii) to evaluate the performance of different ViT architectures to obtain the most advisable one, and (iii) to visualize the brain region mostly affect the prediction of deep learning approach to MCI progression.ResultsOur method achieved state-of-the-art classification performance in terms of accuracy (83.27%), specificity (85.07%), and sensitivity (81.48%) compared with a set of conventional methods. Next, we visualized the brain regions that mostly contribute to the prediction of MCI progression for interpretability of the proposed model. The discriminative pathological locations include the thalamus, medial frontal, and occipital—corroborating the reliability of our model.ConclusionIn conclusion, our methods provide an effective and accurate technique for the prediction of MCI conversion to AD. The results obtained in this study outperform previous reports using the ADNI collection, and it suggests that sMRI-based ViT could be efficiently applied with a considerable potential benefit for AD patient management. The brain regions mostly contributing to prediction, in conjunction with the identified anatomical features, will support the building of a robust solution for other neurodegenerative diseases in future.
Cromolyn prevents cerebral vasospasm and dementia by targeting WDR43
Authors: Wang Xingqiao , Kong Fanqiang , Lin Zengbin 
Published: April 2023

BackgroundCerebral vasospasm (CV) can cause inflammation and damage to neuronal cells in the elderly, leading to dementia.PurposeThis study aimed to investigate the genetic mechanisms underlying dementia caused by CV in the elderly, identify preventive and therapeutic drugs, and evaluate their efficacy in treating neurodegenerative diseases.MethodsGenes associated with subarachnoid hemorrhage and CV were acquired and screened for differentially expressed miRNAs (DEmiRNAs) associated with aneurysm rupture. A regulatory network of DEmiRNAs and mRNAs was constructed, and virtual screening was performed to evaluate possible binding patterns between Food and Drug Administration (FDA)-approved drugs and core proteins. Molecular dynamics simulations were performed on the optimal docked complexes. Optimally docked drugs were evaluated for efficacy in the treatment of neurodegenerative diseases through cellular experiments.ResultsThe study found upregulated genes (including WDR43 and THBS1) and one downregulated gene associated with aneurysm rupture. Differences in the expression of these genes indicate greater disease risk. DEmiRNAs associated with ruptured aortic aneurysm were identified, of which two could bind to THBS1 and WDR43. Cromolyn and lanoxin formed the best docking complexes with WDR43 and THBS1, respectively. Cellular experiments showed that cromolyn improved BV2 cell viability and enhanced Aβ42 uptake, suggesting its potential as a therapeutic agent for inflammation-related disorders.ConclusionThe findings suggest that WDR43 and THBS1 are potential targets for preventing and treating CV-induced dementia in the elderly. Cromolyn may have therapeutic value in the treatment of Alzheimer’s disease and dementia.
Effect of Theta Burst Stimulation-Patterned rTMS on Motor and Nonmotor Dysfunction of Parkinson's Disease: A Systematic Review and Metaanalysis
Authors: Cheng Bo , Zhu Tao , Zhao Wenhao , Sun Ling , Shen Yao , Xiao Wei , Zhang Shushan 
Published: April 2023

Background: Theta burst stimulation (TBS), a type of patterned repetitive transcranial magnetic stimulation (rTMS), has several advantages, such as short time of single treatment and low stimulation intensity compared with traditional rTMS. Since the efficacy of TBS on the symptoms of Parkinson's disease (PD) was inconsistent among different studies, we systematically searched these studies and quantitatively analyzed the therapeutic effect of TBS for patients with PD.Methods: We followed the recommended PRISMA guidelines for systematic reviews. Studies from PubMed, EMBASE, CENTRAL, and ClinicalTrials.gov from January 1, 2005 of each database to September 30, 2021 were analyzed. We also manually retrieved studies of reference.Results: Eight eligible studies with 189 participants (received real TBS and/or sham TBS) were included. This metaanalysis found that TBS did not significantly improve Unified Parkinson's Disease Rating Scale part III (UPDRS-III) score in the “on” medicine state (SMD = −0.06; 95% CI, −0.37 to 0.25; p = 0.69; I2 = 0%), while, it brought significant improvement of UPDRS-III scores in the “off” medicine state (SMD = −0.37; 95% CI, −0.65 to −0.09; p &lt; 0.01; I2 = 19%). Subgroup analysis found that merely continuous TBS (cTBS) over the supplementary motor area (SMA) brought significant improvement of UPDRS-III score (SMD = −0.63; 95% CI, −1.02 to −0.25; p &lt; 0.01). TBS had insignificant effectiveness for upper limb movement disorder both in the “on” and “off” medicine status (SMD = −0.07; 95% CI, −0.36 to 0.22; p = 0.64; I2 = 0%; SMD = −0.21; 95% CI, −0.57 to 0.15; p = 0.26; I2 = 0%; respectively). TBS significantly improved slowing of gait in the “off” medicine status (SMD = −0.37; 95% CI, −0.71 to −0.03; p = 0.03; I2 = 0%). Subgroup analysis suggested that only intermittent TBS (iTBS) over the primary motor cortex (M1) + dorsolateral prefrontal cortex (DLPFC) had significant difference (SMD = −0.57; 95% CI, −1.13 to −0.01; p = 0.04). Additionally, iTBS over the M1+ DLPFC had a short-term (within 2 weeks) therapeutic effect on PD depression (MD = −2.93; 95% CI, −5.52 to −0.33; p = 0.03).Conclusion: Our study demonstrated that cTBS over the SMA could significantly improve the UPDRS-III score for PD patients in the “off,” not in the “on,” medicine state. TBS could not bring significant improvement of upper limb movement dysfunction. ITBS over the M1+DLPFC could significantly improve the slowing of gait in the “off” medicine status. Additionally, iTBS over the M1+DLPFC has a short-term (within 2 weeks) therapeutic effect on PD depression. Further RCTs of a large sample, and excellent design are needed to confirm our conclusions.