bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of mesenchymal estrogen receptor 1 in mouse uterus in response to estrogen
Authors: Furuminato Keita , Minatoya Saki , Senoo Eriko , Goto Tatsuki , Yamazaki Sho , Sakaguchi Moeka , Toyota Kenji , Iguchi Taisen , Miyagawa Shinichi 
Published: July 2023

AbstractEstrogens play important roles in uterine growth and homeostasis through estrogen receptors (ESR1 and ESR2). To address the role of ESR1-mediated tissue events in the murine uterus, we analyzed mice with a mesenchymal tissue-specific knockout of Esr1. Isl1-driven Cre expression generated Esr1 deletion in the uterine stroma and endometrium (Isl-Esr1KO). We showed that overall structure of the Isl1-Esr1KO mouse uterus developed normally, but estrogen responsiveness and subsequent growth were defective, suggesting that mesenchymal ESR1 is necessary for both epithelial and mesenchymal cell proliferation. Furthermore, RNA-seq analysis revealed that the majority of estrogen-induced genes were regulated by stromal ESR1. In control mice, E2 administration induced 9476 up-regulated differentially expressed genes (DEGs), whereas only 1801 up-regulated DEGs were induced by E2 in Isl1-Esr1KO mice. We further showed that stromal ESR1-regulated genes in the mouse uterus included several growth factors and cytokines, which are potential factors that regulate epithelial and stromal tissue interaction, and also genes involved in lipid homeostasis. Therefore, we infer that stromal ESR1 expression is indispensable for most estrogen actions in the mouse uterus and the current results provide new insights into estrogen-mediated homeostasis in female reproductive organs.
Comparing the contribution of each clinical indicator in predictive models trained on 980 subacute stroke patients: a retrospective study
Authors: Miyazaki Yuta , Kawakami Michiyuki , Kondo Kunitsugu , Tsujikawa Masahiro , Honaga Kaoru , Suzuki Kanjiro , Tsuji Tetsuya 
Published: July 2023

AbstractPost-stroke disability affects patients’ lifestyles after discharge, and it is essential to predict functional recovery early in hospitalization to allow time for appropriate decisions. Previous studies reported important clinical indicators, but only a few clinical indicators were analyzed due to insufficient numbers of cases. Although review articles can exhaustively identify many prognostic factors, it remains impossible to compare the contribution of each predictor. This study aimed to determine which clinical indicators contribute more to predicting the functional independence measure (FIM) at discharge by comparing standardized coefficients. In this study, 980 participants were enrolled to build predictive models with 32 clinical indicators, including the stroke impairment assessment set (SIAS). Trunk function had the most significant standardized coefficient of 0.221. The predictive models also identified easy FIM sub-items, SIAS, and grip strength on the unaffected side as having positive standardized coefficients. As for the predictive accuracy of this model, R2 was 0.741. This is the first report that included FIM sub-items separately in post-stroke predictive models with other clinical indicators. Trunk function and easy FIM sub-items were included in the predictive model with larger positive standardized coefficients. This predictive model may predict prognosis with high accuracy, fewer clinical indicators, and less effort to predict.
Portrait of intense communications within microfluidic neural networks
Authors: Dupuit Victor , Briançon-Marjollet Anne , Delacour Cécile 
Published: July 2023

AbstractIn vitro model networks could provide cellular models of physiological relevance to reproduce and investigate the basic function of neural circuits on a chip in the laboratory. Several tools and methods have been developed since the past decade to build neural networks on a chip; among them, microfluidic circuits appear to be a highly promising approach. One of the numerous advantages of this approach is that it preserves stable somatic and axonal compartments over time due to physical barriers that prevent the soma from exploring undesired areas and guide neurites along defined pathways. As a result, neuron compartments can be identified and isolated, and their interconnectivity can be modulated to build a topological neural network (NN). Here, we have assessed the extent to which the confinement imposed by the microfluidic environment can impact cell development and shape NN activity. Toward that aim, microelectrode arrays have enabled the monitoring of the short- and mid-term evolution of neuron activation over the culture period at specific locations in organized (microfluidic) and random (control) networks. In particular, we have assessed the spike and burst rate, as well as the correlations between the extracted spike trains over the first stages of maturation. This study enabled us to observe intense neurite communications that would have been weaker and more delayed within random networks; the spiking rate, burst and correlations being reinforced over time in terms of number and amplitude, exceeding the electrophysiological features of standard cultures. Beyond the enhanced detection efficiency that was expected from the microfluidic channels, the confinement of cells seems to reinforce neural communications and cell development throughout the network.
Statistical analysis of the impact of FeO3 and ZnO nanoparticles on the physicochemical and dielectric performance of monoester-based nanofluids
Authors: Jiosseu Jean Lambert , Jean-Bernard Asse , Mengata Mengounou Ghislain , Tchamdjio Nkouetcha Emeric , Moukengue Imano Adolphe 
Published: July 2023

AbstractThis article deals with a comparative study of the physicochemical and electrical properties of monoesters of castor oil compared with their counterparts based on FeO3 and ZnO nanoparticles. The results are also compared with those in the literature on triesters, and also with the recommendations of the IEEE C 57.14 standard. The data is analysed statistically using a goodness-of-fit test. The analysis of the viscosity data at 40 °C shows an increase in viscosity. For concentrations of 0.10 wt%, 0.15 wt% and 0.20 wt% these are respectively 5.4%, 9.69%, 12.9% for FeO3 NFs and 7.6%, 9.91% and 12.7% for ZnO NFs. For the same concentrations, the increase in acid number is respectively 3.2%, 2.9%, 2.5% for FeO3 samples and 3.18%, 2.0%, 1.2% for ZnO samples. For the same concentrations, the fire point shows an increment of 4%, 3% and 2% for FeO3 samples and a regression of 8.75%, 6.88% and 5.63% for ZnO samples. As for the breakdown voltage, for the same concentrations we observe respectively an increment of 43%, 27%, 34% for the FeO3. The results show an improvement on partial discharge inception voltage with FeO3 of 24%, 8.13% and 15.21% respectively for the concentrations 0.10 wt%, 0.15 wt% and 0.20 wt%.
Optical and pharmacological manipulation of hypoglossal motor nucleus identifies differential effects of taltirelin on sleeping tonic motor activity and responsiveness
Authors: Aggarwal Jasmin , Ladha Raina , Liu Wen-Ying , Liu Hattie , Horner Richard L. 
Published: July 2023

AbstractPharyngeal muscle activity and responsiveness are key pathophysiological traits in human obstructive sleep apnea (OSA) and strong contributors to improvements with pharmacotherapy. The thyrotropin-releasing hormone (TRH) analog taltirelin is of high pre-clinical interest given its neuronal-stimulant properties, minimal endocrine activity, tongue muscle activation following microperfusion into the hypoglossal motor nucleus (HMN) or systemic delivery, and high TRH receptor expression at the HMN compared to rest of the brain. Here we test the hypothesis that taltirelin increases HMN activity and/or responsivity to excitatory stimuli applied across sleep–wake states in-vivo. To target hypoglossal motoneurons with simultaneous pharmacological and optical stimuli we used customized “opto-dialysis” probes and chronically implanted them in mice expressing a light sensitive cation channel exclusively on cholinergic neurons (ChAT–ChR2, n = 12) and wild-type mice lacking the opsin (n = 10). Both optical stimuli applied across a range of powers (P < 0.001) and microperfusion of taltirelin into the HMN (P < 0.020) increased tongue motor activity in sleeping ChAT–ChR2 mice. Notably, taltirelin increased tonic background tongue motor activity (P < 0.001) but not responsivity to excitatory optical stimuli across sleep–wake states (P > 0.098). This differential effect on tonic motor activity versus responsivity informs human studies of the potential beneficial effects of taltirelin on pharyngeal motor control and OSA pharmacotherapy.
Social support, oral health knowledge, attitudes, practice, self-efficacy and oral health-related quality of life in Chinese college students
Authors: Wang Ying , Zhu Jie , Xu Zeling , Dai Xinyi , Chen Keda , Wang Ying 
Published: July 2023

AbstractOral health is crucial for health-related quality of life. However, the research on the factors affecting oral health status is not comprehensive enough. This investigation aimed to evaluate the multifaceted determinants of college students’ oral health status and explore the impact of social support, oral health literacy, attitudes, behaviors, and self-efficacy on OHRQoL. By surveying 822 students from a university. Baseline data included sociodemographics (gender, age), social support (MSPSS scale), oral health self-efficacy (SESS scale), oral health knowledge, attitudes, and practices (KAP questionnaire), and OHRQoL (OHIP-14 scale). Based on social cognitive theory, partial least squares structural equation modeling (PLS-SEM) and fuzzy set qualitative comparative analysis (fsQCA) were used to examine the relationship between the study variables. PLS-SEM results showed that knowledge, attitude, and practice predicted OHRQoL through self-efficacy. FsQCA results showed that the combination of different variables was sufficient to explain OHRQoL. The conclusion was that self-efficacy plays an important role and the combination of high-level knowledge, positive attitudes, and strong self-efficacy was important in improving OHRQoL. The results of this study provided a reference for the oral health strategy planning of college students in China.
Distinct decadal modulation of Atlantic-Niño influence on ENSO
Authors: Park Jae-Heung , Kug Jong-Seong , Yang Young-Min , Sung Mi-Kyung , Kim Sunyong , Kim Hyo-Jeong , Park Hyo-Jin , An Soon-Il 
Published: July 2023

AbstractIt is known that winter Atlantic-Niño events can induce the El Niño–Southern oscillation (ENSO) in the following winter with a lag of 1-year during one period. On the other hand, summer Atlantic-Niño events can lead to the ENSO in the subsequent winter with a half-year lag during another period. In this study, we investigate the distinct interdecadal modulation of the effect of the Atlantic-Niños on ENSO by analyzing observational reanalysis datasets. During the mid-twentieth century, the winter Atlantic-Niño exhibited increased intensity and extended westward due to warmer conditions in the tropical western Atlantic. As a result, convection occurred from the Amazon to the Atlantic, triggering an atmospheric teleconnection that led to trade wind discharging and equatorial Kelvin waves, ultimately contributing to the development of ENSO. In contrast, during late twentieth century, summer Atlantic-Niño events were closely linked to the South America low-level jet in boreal spring. This connection led to the formation of widespread and intense convection over the Amazon to the Atlantic region. Then, the Walker circulation was effectively modulated, subsequently triggering ENSO events. Further analysis revealed that the interdecadal modulation of the Atlantic–South America–Pacific mean state plays a crucial role in shaping the impact of Atlantic-Niños on ENSO by modifying not only the characteristics of the Atlantic-Niños but also ocean–atmospheric feedback process. Therefore, improving our understanding of the interdecadal modulation of the climatological mean state over the Pacific to Atlantic regions enables better anticipation of the interaction between the Atlantic and Pacific Oceans.
Combined influences of sources and atmospheric bleaching on light absorption of water-soluble brown carbon aerosols
Authors: Fang Wenzheng , Andersson August , Lee Meehye , Zheng Mei , Du Ke , Kim Sang-Woo , Holmstrand Henry , Gustafsson Örjan 
Published: July 2023

AbstractLight-absorbing Brown Carbon (BrC) aerosols partially offset the overall climate-cooling of aerosols. However, the evolution of BrC light-absorption during atmospheric transport is poorly constrained. Here, we utilize optical properties, ageing-diagnostic δ13C-BrC and transport time to deduce that the mass absorption cross-section (MACWS-BrC) is decreasing by ~50% during long-range oversea transport, resulting in a first-order bleaching rate of 0.24 day‒1 during the 3-day transit from continental East Asia to a south-east Yellow Sea receptor. A modern 14C signal points to a strong inverse correlation between BrC light-absorption and age of the source material. Combining this with results for South Asia reveals a striking agreement between these two major-emission regions of rapid photobleaching of BrC with a higher intrinsic absorptivity for BrC stemming from biomass burning. The consistency of bleaching parameters constrained independently for the outflows of both East and South Asia indicates that the weakening of BrC light absorption, thus primarily related to photochemical processes rather than sources, is likely a ubiquitous phenomenon.
An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis
Authors: Talvio Karo , Wagner Victoria A. , Minkeviciene Rimante , Kirkwood Jay S. , Kulinich Anna O. , Umemori Juzoh , Bhatia Anil , Hur Manhoi , Käkelä Reijo , Ethell Iryna M. , Castrén Maija L. 
Published: July 2023

AbstractCholesterol is an essential membrane structural component and steroid hormone precursor, and is involved in numerous signaling processes. Astrocytes regulate brain cholesterol homeostasis and they supply cholesterol to the needs of neurons. ATP-binding cassette transporter A1 (ABCA1) is the main cholesterol efflux transporter in astrocytes. Here we show dysregulated cholesterol homeostasis in astrocytes generated from human induced pluripotent stem cells (iPSCs) derived from males with fragile X syndrome (FXS), which is the most common cause of inherited intellectual disability. ABCA1 levels are reduced in FXS human and mouse astrocytes when compared with controls. Accumulation of cholesterol associates with increased desmosterol and polyunsaturated phospholipids in the lipidome of FXS mouse astrocytes. Abnormal astrocytic responses to cytokine exposure together with altered anti-inflammatory and cytokine profiles of human FXS astrocyte secretome suggest contribution of inflammatory factors to altered cholesterol homeostasis. Our results demonstrate changes of astrocytic lipid metabolism, which can critically regulate membrane properties and affect cholesterol transport in FXS astrocytes, providing target for therapy in FXS.
The silkworm (Bombyx mori) gut microbiota is involved in metabolic detoxification by glucosylation of plant toxins
Authors: Yuan Shuangzhi , Sun Yong , Chang Wenqiang , Zhang Jiaozhen , Sang Jifa , Zhao Jiachun , Song Minghui , Qiao Yanan , Zhang Chunyang , Zhu Mingzhu , Tang Yajie , Lou Hongxiang 
Published: July 2023

AbstractHerbivores have evolved the ability to detoxify feed components through different mechanisms. The oligophagous silkworm feeds on Cudrania tricuspidata leaves (CTLs) instead of mulberry leaves for the purpose of producing special, high-quality silk. However, CTL-fed silkworms are found to have smaller bodies, slower growth and lower silk production than those fed mulberry leaves. Here, we show that the high content of prenylated isoflavones (PIFs) that occurred in CTLs is converted into glycosylated derivatives (GPIFs) in silkworm faeces through the silkworm gut microbiota, and this biotransformation is the key process in PIFs detoxification because GPIFs are found to be much less toxic, as revealed both in vitro and in vivo. Additionally, adding Bacillus subtilis as a probiotic to remodel the gut microbiota could beneficially promote silkworm growth and development. Consequently, this study provides meaningful guidance for silk production by improving the adaptability of CTL-fed silkworms.
Benzothiadiazole-based rotation and possible antipolar order in carboxylate-based metal-organic frameworks
Authors: Schnabel Jennifer , Schulz Arthur , Lunkenheimer Peter , Volkmer Dirk 
Published: July 2023

AbstractBy modifying organic ligands of metal-organic framework with dipolar units, they turn suitable for various applications, e.g., in the field of sensor systems or switching of gas permeation. Dipolar linkers in the organic ligand are capable to rotate in certain temperature and frequency ranges. The copper-bearing paddlewheel shaped metal-organic frameworks ZJNU-40 and JLU-Liu30 possess such a polarizable dipole moment due to their benzothiadiazole moiety in the organic ligands. Here, we investigate the molecular rotor behavior of benzothiadiazole units of the two carboxylate-based MOFs by dielectric spectroscopy and computational simulation. Our dielectric results provide clear evidence for significant reorientational relaxation dynamics of these rotors, revealing various characteristics of glasslike freezing upon cooling. The calculated rotational energy barriers are consistent with experimentally determined barriers for single-dipole dynamics. Moreover, for JLU-Liu30 we find hints at antipolar ordering below about 300 K.
Spin dynamics, loop formation and cooperative reversal in artificial quasicrystals with tailored exchange coupling
Authors: Bhat Vinayak Shantaram , Watanabe Sho , Kronast Florian , Baumgaertl Korbinian , Grundler Dirk 
Published: July 2023

AbstractAperiodicity and un-conventional rotational symmetries allow quasicrystalline structures to exhibit unusual physical and functional properties. In magnetism, artificial ferromagnetic quasicrystals exhibited knee anomalies suggesting reprogrammable magnetic properties via non-stochastic switching. However, the decisive roles of short-range exchange and long-range dipolar interactions have not yet been clarified for optimized reconfigurable functionality. We report broadband spin-wave spectroscopy and X-ray photoemission electron microscopy on different quasicrystal lattices consisting of ferromagnetic Ni81Fe19nanobars arranged on aperiodic Penrose and Ammann tilings with different exchange and dipolar interactions. We imaged the magnetic states of partially reversed quasicrystals and analyzed their configurations in terms of the charge model, geometrical frustration and the formation of flux-closure loops. Only the exchange-coupled lattices are found to show aperiodicity-specific collective phenomena and non-stochastic switching. Both, exchange and dipolarly coupled quasicrystals show magnonic excitations with narrow linewidths in minor loop measurements. Thereby reconfigurable functionalities in spintronics and magnonics become realistic.
Recycled carbonates elevate the electrical conductivity of deeply subducting eclogite in the Earth’s interior
Authors: Jing Chenxin , Hu Haiying , Dai Lidong , Sun Wenqing , Wang Mengqi , Hu Ziming 
Published: July 2023

AbstractThe elevated pressure and temperature conditions encountered by a subducted slab entering the deep Earth can substantially alter the chemical composition and physical properties of recycled carbonates. Carbonate-silicate reactions are believed to have a pivotal role in this process. Here we conduct high temperature and high pressure experiments on carbonated eclogite and measure the electrical conductivity in order to constrain the evolution of geophysical properties and chemical composition in the carbonate-bearing eclogitic slab. We find that the carbonate-silicate reaction elevates the conductivity of carbonated eclogite by cations (e.g., Ca, Mg, Fe) exchange between carbonates and silicate. We propose that carbonate-silicate cations exchange can alter the chemical composition of recycled carbonates, potentially impacting their stability and reducing the solidus temperature of carbonate-bearing systems. Combining thermodynamic calculations with the elevated conductivity in our experiments, we re-evaluate the contribution of recycled carbonates to the Earth mantle geophysical anomalies and obtain the potential carbonate capacity in the subducting slab.
Towards CRISP‐BC: 3TIC specification framework for Blockchain use‐cases
Authors: Jahanbin Pouyan , Sharma Ravi S. , Wingreen Stephen T. , Kshetri Nir , Choo Kim‐Kwang Raymond 
Published: July 2023

AbstractThe application of Blockchain and augmented technologies such as IoT, AI, and Big Data platforms present a feasible approach for resolving the implementation challenges of trusted, decentralized platforms. This article proposes a DevOps framework for the specification of Blockchain use‐cases that enables evaluation, replication, and benchmarking. Specifically, it could be applied to specify the requirements and design characteristics of Blockchain applications in terms of key attributes such as: (i) transparency; (ii) traceability; (iii) tamper‐resistance; (iv) immutability; and (v) compliance. The article first introduces the design characteristics of Blockchain as a Platform and then examines successful use‐cases for its implementation using the above attributes. It may be conjectured that the 3TIC framework would serve as the basis of a cross industry process for Blockchain. The intended contribution is that such a standard process will support industry‐academia collaboration in the development of Blockchain platforms and services of relevance and utility as it can be applied by firms to structure their requirements and design specifications.
Optimal fusion‐based localization method for tracking of smartphone user in tall complex buildings
Authors: Jamil Harun , Kim Do‐Hyeun 
Published: July 2023

AbstractIn the event of a fire breaking out or in other complicated situations, a mobile computing solution combining the Internet of Things and wearable devices can actually assist tracking solutions for rescuing and evacuating people in multistory structures. Thus, it is crucial to increase the positioning technology's accuracy. The sequential Monte Carlo (SMC) approach is used in various applications such as target tracking and intelligent surveillance, which rely on smartphone‐based inertial data sequences. However, the SMC method has intrinsic flaws, such as sample impoverishment and particle degeneracy. A novel SMC approach is presented, which is built on the weighted differential evolution (WDE) algorithm. Sequential Monte Carlo approaches start with random particle placements and arrives at the desired distribution with a slower variance reduction, like in a high‐dimensional space, such as a multistory structure. Weighted differential evolution is included before the resampling procedure to guarantee the appropriate variety of the particle set, prevent the usage of an inadequate number of valid samples, and preserve smartphone user position accuracy. The values of the smartphone‐based sensors and BLE‐beacons are set as input to the SMC, which aids in fast approximating the posterior distributions, to speed up the particle congregation process in the proposed SMC‐based WDE approach. Lastly, the robustness and efficacy of the suggested technique more accurately reflect the actual situation of smartphone users. According to simulation findings, the suggested approach provides improved location estimation with reduced localization error and quick convergence. The results confirm that the proposed optimal fusion‐based SMC‐WDE scheme performs 9.92% better in terms of MAPE, 15.24% for the case of MAE, and 0.031% when evaluating based on the R2 Score.