bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bringing Trauma Education to the Frontier: Overcoming Distance Barriers Utilizing a Virtual Platform
Authors: McCotter Elizabeth L. , Peterson Alexa L. , Savell Tessa C. , Orr Lanny C. , Besel Jamie M. , Thompson Simon J. 
Published: July 2023

BACKGROUND:
The American College of Surgeons and state regulations mandate that trauma facilities offer trauma-specific continuing education throughout the region they serve. These requirements come with unique challenges when serving a rural and sparsely populated state. A novel approach to providing education was necessitated by the coronavirus disease 2019 pandemic, travel distance, and limited local specialists.

OBJECTIVE:
The purpose of this article is to describe the development of a virtual educational program used to improve access to quality trauma education and decrease barriers to obtaining continuing education hours inherent in the region.

METHODS:
This article describes the development and implementation of the Virtual Trauma Education program, which provided one free continuing education hour per month from October 2020 to October 2021. The program reached more than 2,000 viewers and established a method to provide continuous monthly educational offerings throughout the region.

RESULTS:
After the Virtual Trauma Education program implementation, monthly educational attendance increased from an average of 55 to 190. Viewership data indicate that trauma education across our region is far more robust, available, and accessible using a virtual platform. With more than 2,000 views from October 2020 to October 2021, Virtual Trauma Education offerings have spread far beyond regional borders, reaching 25 states and 169 communities.

CONCLUSION:
Virtual Trauma Education delivers easily accessible trauma education and is a program that has proven its sustainability.
Transvenous embolization using the Amplatzer Vascular Plug II in patent ductus arteriosus concomitant with Stanford type B aortic dissection: A case report
Authors: Woo Jong Hun , Shim Jongjoon , Lee Jae Myeong 
Published: July 2023

Rationale:
Thoracic endovascular aneurysm repair (TEVAR) is commonly used to treat Stanford type B aortic dissections. However, coexistence of aortic dissection and patent ductus arteriosus (PDA) is an extremely rare phenomenon, and TEVAR alone is insufficient for treatment. Herein, a case of endovascular treatment in a patient with both aortic dissection and PDA is reported.

Patient concerns:
A 31-year-old woman presented to the authors’ hospital with chest pain extending to the back. At presentation, her blood pressure was 130/70 mm Hg. Her father, brother, and uncle were all diagnosed with aortic dissection.

Diagnoses:
Computed tomography (CT) revealed Stanford type B aortic dissection from the aortic arch to the infrarenal abdominal aorta; however, PDA was incidentally identified.

Interventions:
TEVAR was immediately performed. Follow-up CT scan performed 2 months later did not reveal any thrombosis or remodeling of the false lumen, and the PDA remained open. Therefore, an additional PDA embolization procedure was performed using the Amplatzer Vascular Plug II via the transvenous route.

Outcomes:
On follow-up CT performed 6 months after PDA embolization, successful remodeling, and shrinkage of the false lumen were observed, and PDA closure was confirmed.

Lessons:
If Stanford type B aortic dissection and PDA coexist, TEVAR alone may not be a sufficient treatment and additional PDA embolization may be required. In the present case, transvenous embolization of PDA using an Amplatzer Vascular Plug II was safe and effective.
Meningitis with septic shock resulting from odontogenic infection misdiagnosed as closed-lock in temporomandibular disorder: A case report and literature review
Authors: Yoshizawa Kunio , Hanihara Mitsuto , Harada Daiki , Myose Natsuhiko , Sakata Hiroki , Moriguchi Takeshi , Moroi Akinori , Ueki Koichiro 
Published: July 2023

Rationale:
Infections that spread to the pterygomandibular muscle can be misdiagnosed as temporomandibular disorder (TMD) because of the resulting difficulty in opening the mouth. Importantly, infection of the pterygomandibular space can extend to the skull base in the early stages, and a delay in therapeutic intervention can lead to severe complications.

Patient concerns:
A 77-year-old Japanese man with trismus after pulpectomy was referred to our department. This case report describes a rare instance of meningitis with septic shock caused by an odontogenic infection, initially misdiagnosed as TMD due to similar symptoms, leading to life-threatening complications.

Diagnosis:
The patient was diagnosed with sepsis and meningitis resulting from cellulitis in the pterygomandibular space caused by iatrogenic infection after pulpectomy of the right upper second molar.

Interventions:
After emergency hospitalization, the patient developed septic shock and required blood purification. Subsequently, abscess drainage and extraction of the causative tooth were performed. However, the patient developed hydrocephalus secondary to meningitis and underwent ventriculoperitoneal shunting to alleviate the condition.

Outcomes:
The infection was controlled and the patient level of consciousness improved following treatment for hydrocephalus. The patient was transferred to a hospital for rehabilitation on the 106th day of hospitalization.

Lessons:
Infections of the pterygomandibular space may be misdiagnosed as TMD, owing to the main symptoms of restricted mouth opening and pain on mouth opening. A prompt and appropriate diagnosis is crucial because these infections can lead to life-threatening complications. A detailed interview, along with additional blood tests and computed tomography (CT) scans, can aid in making an accurate diagnosis.
Bibliometric and visualized analysis of the top-100 highly cited articles on immunotherapy for endometrial cancer
Authors: Zheng Wanzhen , Wu Yinjie , Wang Yu , Cheng Jiaxin , Shen Wenjing 
Published: July 2023

Background:
Immunotherapy is a promising method for the treatment of endometrial cancer (EC). We aimed to conduct a comprehensive bibliometric study of the top 100 most-cited publications on immunotherapy for EC and provide a reference for future research.

Methods:
Global publications on immunotherapy for EC published from 1985 to the present in the Web of Science core database were retrieved. We focused on the study of the top 100 most-cited articles by extracting information such as year, country, journal, author, institution, literature, and keywords. Microsoft Excel, VOSviewer, and R were used to perform descriptive statistics and visual analyses.

Results:
The top 100 most-cited articles were published between 2002 and 2022, including 70 original papers and 30 reviews. The total frequency of citations per article ranges from 15 to 287. Developed countries dominated these publications, with the United States contributing the most (50 articles). According to Bradford Law, 6 journals, including Gynecologic Oncology and the Journal of Clinical Oncology, are highly recommended. Santin A. D. from Yale University and Makker.V. from Memorial Sloan Kettering Cancer Center have made positive contributions. Among the top ten most-cited articles, 7 focused on clinical trials exploring the efficacy of immunotherapy drugs, of which 4 were lenvatinib combined with pembrolizumab for the treatment of advanced EC. The immune-microenvironment, immune antitumor mechanisms, immunomodulatory drugs, especially anti-pd-1/pd-l1 checkpoint inhibitors, and their clinical trials are the focus of current research.

Conclusion:
The attention of researchers from different countries to EC immunotherapy, especially immunosuppressants, has brought a breakthrough in this field. A large number of clinical trials have evaluated the efficacy and safety of immune agents, and immune combination therapy (especially targeted therapy) shows positive therapeutic promise. Immunodrug sensitivity and adverse events remain urgent issues. The key to promoting the development of EC immunotherapy is to select the best patients according to the molecular classification and immunophenotype such as tumor mutation load, MMR status, pd-l1 expression, tumor infiltrating immune cells to truly achieve accurate and personalized treatment. More new and influential EC immunotherapies, such as adoptive cell immunotherapy, still need to be explored in future clinical practice.
A splicing mutation of the FLCN gene is associated with Birt-Hogg-Dubé syndrome characterized by familial and recurrent spontaneous pneumothorax: A case report
Authors: Xiao Hua , Chi Feng , Li Shuai , Wang Tao , Bai Bin , Hou Jia , Ge Xiahui 
Published: July 2023

Rationale:
Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal recessive genetic disorder caused mainly by mutations in the tumor suppressor FLCN gene. Tumors caused by FLCN mutations are frequently benign and develop in skin, lungs, kidney, and other organs, leading to a variety of phenotypes that make early diagnoses of BHD challenging.

Patient concerns:
A 51-year-old female was admitted to Shanghai Seventh People Hospital due to chest congestion and dyspnea that had persisted for 3 years and aggravated for 1 month. She had been diagnosed with pneumothorax prior to this submission, but the etiology was unknown.

Diagnoses:
Chest computed tomography (CT) revealed multiple pulmonary cysts and pneumothorax, and her family members shared similar manifestation. Whole-exome sequencing analysis indicated a heterozygous FLCN splicing mutation (c.1432 + 1G > A; rs755959303), which was a pathogenic variant indicated in ClinVar. Based on FLCN mutation and the family history of pulmonary cysts and pneumothorax, BHD syndrome was finally diagnosed, which had been delayed for 3 years since her first pneumothorax.

Interventions:
Pulmonary bullectomy and pleurodesis were finally conducted due to the poor effects of thoracic close drainage.

Outcomes:
Her pneumothorax was resolved, and no recurrence was found in 2 years.

Lessons:
Our study highlights the importance of genetic analysis in diagnosis and clinical management of BHD syndrome.
Displays of 18F-FAPI PET/CT in Myocarditis With Variable Symptom Durations
Authors: Zhou Weicheng , Sun Jinju , Wang Fangyang , Wang Yi , Chen Xiao 
Published: July 2023

Abstract
We report cardiac 18F-FAPI PET/CT findings in 3 cases with myocarditis of varying duration (7 hours, 1 week, and 1 month). Myocarditis with varying symptom durations showed different 18F-FAPI uptake, suggesting that the 18F-FAPI PET/CT may be helpful in evaluating the extent of fibrosis caused by myocarditis. This information may assist in treatment decision-making for patients with myocarditis.
Study on Microsurgical Anatomy of External Branch of Superior Laryngeal Nerve Related to Carotid Endarterectomy
Authors: Wu Xiangchen , Tong Xiaoguang , Shi Minggang , Shang Yanguo 
Published: July 2023

Objective:
To explore the methods of protecting the external branch of the superior laryngeal nerve during carotid endarterectomy through microsurgical anatomic study of the external branch of the superior laryngeal nerve in cadaveric specimens.

Methods:
A total of 30 cadaveric specimens (60 sides) were dissected to measure the thickness of the external branch of the superior laryngeal nerve. A triangular area was exposed, bounded by the lower border of the digastric muscle superiorly, the medial edge of the sternocleidomastoid muscle laterally, and the upper border of the superior thyroid artery inferiorly. The probability of the occurrence of the external branch of the superior laryngeal nerve in this area was observed and recorded. The distance among the midpoint of the external branch of the superior laryngeal nerve in this area with the tip of the mastoid process and the angle of the mandible as well as the bifurcation of the common carotid artery was measured and recorded.

Results:
Among 30 specimens of cadaveric heads (60 sides) examined 53 external branches of the superior laryngeal nerve were observed while 7 were absent. Of the 53 branches observed, 5 were located outside the anatomic triangle region mentioned above, while the remaining 48 branches were located within the anatomic triangle region with a probability of ~80%. The thickness of the midpoint of the external branches of the superior laryngeal nerve within the anatomic triangle region was 0.93 mm (0.72–1.15 mm [±0.83 SD]), located 0.34 cm [−1.62–2.43 cm (±0.96 SD)] posterior to the angle of the mandible, 1.28 cm (−1.33 to 3.42 cm (±0.93 SD)] inferiorly; 2.84 cm (0.51–5.14 cm±1.09 SD) anterior to the tip of the mastoid process, 4.51 cm (2.82–6.39 cm±0.76 SD) inferiorly; 1.64 cm [0.57–3.78 cm (±0.89 SD)] superior to the bifurcation of the carotid artery.

Conclusions:
During carotid endarterectomy procedure, using the cervical anatomic triangle region, as well as the angle of the mandible, the tip of the mastoid process, and the bifurcation of the carotid artery as anatomic landmarks, is of significant clinical importance for protecting the external branches of the superior laryngeal nerve.
Extended Superolateral Cheek Lift With a Short Preauricular Scar: A Local Anesthesia-based Practicable Technique for the Correction of Moderate-degree Facial Aging Signs
Authors: Okumus Ayhan 
Published: July 2023

An ideal technique applicable to middle-aged individuals with a moderate degree of facial aging signs has not yet been established. This study aimed to evaluate the utility of an extended superolateral cheek lift with a short preauricular scar technique for the correction of facial aging signs. A total of 200 female patients (mean age: 43 y, range 27–56 y) who underwent a local anesthesia-based extended superolateral cheek lift for the correction of facial aging signs confined to the malar and nasolabial area, lower eyelid, jawline, and neck were included. Data on the Global Aesthetic Improvement Scale, patient-reported outcomes, and complications were recorded at 1, 6, 12, and 24 months postoperatively. The Global Aesthetic Improvement Scale scores revealed exceptional improvement in 90% of patients along with no complications at month 24. None of the patients developed a depressed scar, skin necrosis, breaking of the superficial musculoaponeurotic system plication sutures, asymmetry, or facial nerve problems. At postoperative month 24, the appearance was reported to be very much improved by 90% of patients, and 94% of patients reported that they were very satisfied with the treatment and that they would recommend this treatment to friends and acquaintances. Our findings revealed the potential utility of an extended superolateral cheek lift with a short preauricular scar as a local anesthesia-based practicable technique for the correction of facial aging signs in middle-aged patients, offering a favorable postoperative outcome, lack of complications and high patient satisfaction in addition to invisible scars and a short-term postoperative recovery.
Sparse spatial scaffolding for visual working memory
Authors: Liu Baiwei , Alexopoulou Zampeta-Sofia , Kong Siyang , Zonneveld Anne , van Ede Freek 
Published: July 2023

AbstractWhen holding information ‘in mind’, it is vital to keep individual representations separated and selectively accessible for behaviour. Space is known to serve as a foundational scaffold for mnemonic individuation, yet the format and flexibility of spatial scaffolding for working memory remain elusive. We hypothesised that information in working memory can be re-coded from its native format at encoding to organise and retain internal representations sparsely. To test this, we presented to-be-memorised visual objects at distinct directions and distances and leveraged gaze biases during mnemonic selection as an implicit read-out of spatial scaffolding for working memory. We report how the human brain abstracts away over incidental object distance when direction alone suffices as a scaffold, but incorporates distance when it aids mnemonic individuation. This unveils the principle of sparse spatial scaffolding for working memory, whereby the human brain flexibly resorts to the minimal spatial scaffold needed for the individuation of internal representations.
Microglia-derived TGF-β1 ligand maintains microglia homeostasis via autocrine mechanism and is critical for normal cognitive function in adult mouse brain
Authors: Bedolla Alicia , Wegman Elliot , Weed Max , Paranjpe Aditi , Alkhimovitch Anastasia , Ifergan Igal , McClain Lucas , Luo Yu 
Published: July 2023

AbstractWhile TGF-β signaling is essential for microglial function, the cellular source of TGF-β ligand and its spatial regulation remains unclear in the adult CNS. Our data support that microglia, not astrocytes or neurons, are the primary producers of TGF-β1 ligands needed for microglial homeostasis. Microglia (MG)-Tgfb1inducible knockout (iKO) leads to the activation of microglia featuring a dyshomeostatic transcriptomic profile that resembles disease-associated microglia (DAMs), injury-associated microglia, and aged microglia, suggesting that microglial self-produced TGF-β1 ligands are important in the adult CNS. Interestingly, astrocytes in MG-Tgfb1iKO mice show a transcriptome profile that closely aligns with A1-like astrocytes. Additionally, using sparse mosaic single-cell microglia iKO of TGF-β1 ligand, we established an autocrine mechanism for TGF-β signaling. Importantly MG-Tgfb1iKO mice show cognitive deficits, supporting that precise spatial regulation of TGF-β1 ligand derived from microglia is critical for the maintenance of brain homeostasis and normal cognitive function in the adult brain.
Low intensity mechanical signals promote proliferation in a cell-specific manner: Tailoring a non-drug strategy to enhance biomanufacturing yields
Authors: Chan M. Ete , Strait Lia , Ashdown Christopher , Pasumarthy Sishir , Hassan Abdullah , Crimarco Steven , Singh Chanpreet , Patel Vihitaben S , Pagnotti Gabriel , Khan Omor , Uzer Gunes , Rubin Clinton T 
Published: July 2023

AbstractBiomanufacturing relies on living cells to produce biotechnology-based therapeutics, tissue engineering constructs, vaccines, and a vast range of agricultural and industrial products. With the escalating demand for these bio-based products, any process that could improve yields and shorten outcome timelines by accelerating cell proliferation would have a significant impact across the discipline. While these goals are primarily achieved usingbiologicalorchemicalstrategies, harnessing cell mechanosensitivity represents a promising – albeit less studied –physicalpathway to promote bioprocessing endpoints, yet identifying which mechanical parameters influence cell activities has remained elusive. We tested the hypothesis that mechanical signals, delivered non-invasively using low-intensity vibration (LIV; <1g, 10-500Hz), will enhance cell expansion, and determined that any unique signal configuration was not equally influential across a range of cell types. Varying frequency, intensity, duration, refractory period, and daily doses of LIV increased proliferation in CHO-adherent cells (+79% in 96h) using a particular set of LIV parameters (0.2g, 500Hz, 3x30 min/d, 2h refractory period), yet this same mechanical inputsuppressedproliferation in CHO-suspension cells (-13%). Exposing these same CHO-suspension cells todistinctLIV parameters (30Hz, 0.7g, 2x60 min/d, 2h refractory period) increased proliferation by 210%. Particle image velocimetry combined with finite element modeling showed high transmissibility of these signals across fluids (>90%), and LIV effectively scaled up to T75 flasks. Ultimately, when LIV is tailored to the target cell population, its highly efficient transmission across media represents a means to non-invasively augment biomanufacturing endpoints for both adherent and suspended cells, and holds immediate applications, ranging from small-scale, patient-specific personalized medicine to large-scale commercial bio-centric production challenges.
Mapping multi-modal dynamic network activity during naturalistic music listening
Authors: Faber Sarah EM , Brown Tanya , Carpentier Sarah , McIntosh Anthony Randal 
Published: July 2023

AbstractThe human brain is a complex, adaptive system capable of parsing complex stimuli and generating complex behaviour. Understanding how to model and interpret the dynamic relationship between brain, behaviour, and the environment will provide vital information on how the brain responds to real-world stimuli, develops and ages, and adapts to pathology. Modelling together numerous streams of dynamic data, however, presents sizable methodological challenges. In this paper, we present a novel workflow and sample interpretation of a data set incorporating brain, behavioural, and stimulus data from a music listening study. We use hidden Markov modelling (HMM) to extract state timeseries from continuous high-dimensional EEG and stimulus data, estimate timeseries variables consistent with HMM from continuous low-dimensional behavioural data, and model the multi-modal data together using partial least squares (PLS). We offer a sample interpretation of the results, including a discussion on the limitations of the currently available tools, and discuss future directions for dynamic multi-modal analysis focusing on naturalistic behaviours.