bluuebunny/crossref_metadata_2025_split huggingface dataset:
Field emission properties of nano-tendril bundles formed via helium plasma exposure with various additional impurity gases
Authors: Zhang Rongshi , Kajita Shin , Hwangbo Dogyun , Tanaka Hirohiko , Feng Shuangyuan , Ohno Noriyasu 
Published: May 2023

Abstract
Nano-tendril bundles (NTBs) were formed on tungsten via helium (He) plasma exposure with various additional impurity gases, such as neon (Ne), nitrogen (N2), and argon (Ar). The sizes of the NTBs showed different distributions with different additional impurity gases. The field emission property of the NTBs formed with various additional impurity gases was measured. The field-emission property was significantly affected by the morphology of the NTBs, especially the tips of the fibers. In the Ne- and Ar-seeded cases, the NTBs were formed with sharp tips, and the onset electric field for field emission was ∼1 kV mm−1 for all the NTB samples. The Ne-seeded samples showed the most rapid increase in the emission current. In the N2-seeded case, two types of NTBs were formed. The NTBs were formed with sharp tips when the ratio of N2 impurity gas was 2.1%. With an increase in the ratio to 3.0% or higher, the fibers of the NTBs became thicker and the tips became rounder. In the Fowler–Nordheim (F-N) plot analysis, the field enhancement factors were approximately 6000–7000 without significant differences, for all NTBs with sharp tips. NTBs with round tips showed totally different field emission property, as the emission current was only several μA, which is one-tenth of that for the other samples. This suggests that the local morphology of NTBs, especially the geometrical shape of the tips, and not the general size of NTBs, is the main factor in determining the field emission property of NTBs.
Macroscopic tensile properties of AlxCoCrCuFeNi (x = 0.3 and 1) before and after heat treatment
Authors: Kiyomiya Kai , Arai Yutaro , Inoue Ryo 
Published: May 2023

Abstract
The relationship between morphology (grain-size order) and mechanical properties of AlxCoCrCuFeNi (x = 0.3 and 1) was evaluated. Both alloys were prepared using the arc-melting method. Crystal structures with x = 0.3, face-centered cubic (FCC), and body-centered cubic (BCC) structures were observed for x = 1, the typical crystal structures of AlxCoCrCuFeNi. The alloys prepared via arc melting exhibited two different microstructures: a Cu-rich region (area I) and an equiatomic region (area II). Microstructures of the as-fabricated specimen were homogenized through heat treatment at 600 and 1000 °C for 5 h. Although the homogenization of the microstructure proceeded, areas I and II remained after the heat treatment. In particular, the area I composition was inconsistent with the predicted phase diagram. Tensile tests for these alloys revealed that the tensile strength of x = 1 (∼310–1100 MPa) is higher than that of x = 0.3 (∼320–660 MPa), whereas the fracture strain of x = 1 (∼0.03–0.09) is lower than that of x = 0.3 (∼0.06–0.26). These results indicate that the increase in Al content caused an increase in strength and brittle fracture because it also caused an increase in the formation of the BCC and B2 phases, which required higher stresses for the movement of dislocations than the FCC phase. Because the tensile properties of AlxCoCrCuFeNi are comparable to those of conventional alloys, such as Ti alloys and steels, a design with a moderate composition for stronger and tougher AlxCoCrCuFeNi is required to apply high entropy alloys to structural materials.
Push-Through Filtration of Emulsified Adipose Tissue Over a 500-µm Mesh Significantly Reduces the Amount of Stromal Vascular Fraction and Mesenchymal Stem Cells
Authors: Ramaut Lisa , Moonen Linde , Laeremans Thessa , Aerts Joeri L , Geeroms Maxim , Hamdi Moustapha 
Published: May 2023

Abstract

Background
Mechanical isolation of the stromal vascular fraction (SVF) separates the stromal component from the parenchymal cells. Emulsification is currently the most commonly used disaggregation method and is effective in disrupting adipocytes and fragmenting the extracellular matrix (ECM). Subsequent push-through filtration of emulsified adipose tissue removes parts of the ECM that are not sufficiently micronized, thereby further liquifying the tissue.

Objectives
The aim of this study was to investigate whether filtration over a 500-µm mesh filter might affect the SVF and adipose-derived mesenchymal stem cell (MSC) quantity in emulsified lipoaspirate samples by removing ECM fragments.

Methods
Eleven lipoaspirate samples from healthy nonobese women were harvested and emulsified in 30 passes. One-half of the sample was filtered through a 500-µm mesh filter and the other half was left unfiltered. Paired samples were processed and analyzed by flow cytometry to identify cellular viability, and SVF and MSC yield.

Results
Push-through filtration reduced the number of SVF cells by a mean [standard deviation] of 39.65% [5.67%] (P &lt; .01). It also significantly reduced MSC counts by 48.28% [6.72%] (P &lt; .01). Filtration did not significantly affect viability (P = .118).

Conclusions
Retention of fibrous remnants by push-through filters removed ECM containing the SVF and MSCs from emulsified lipoaspirates. Processing methods should aim either to further micronize the lipoaspirate before filtering or not to filter the samples at all, to preserve both the cellular component carried within the ECM and the inductive properties of the ECM itself.
Performance of ChatGPT on the Plastic Surgery Inservice Training Examination
Authors: Gupta Rohun , Herzog Isabel , Park John B , Weisberger Joseph , Firouzbakht Peter , Ocon Vanessa , Chao John , Lee Edward S , Mailey Brian A 
Published: May 2023

Abstract

Background
Developed originally as a tool for resident self-evaluation, the Plastic Surgery Inservice Training Examination (PSITE) has become a standardized tool adopted by Plastic Surgery residency programs. The introduction of large language models (LLMs), such as ChatGPT (OpenAI, San Francisco, CA), has demonstrated the potential to help propel the field of Plastic Surgery.

Objectives
The authors of this study wanted to assess whether or not ChatGPT could be utilized as a tool in resident education by assessing its accuracy on the PSITE.

Methods
Questions were obtained from the 2022 PSITE, which was present on the American Council of Academic Plastic Surgeons (ACAPS) website. Questions containing images or tables were carefully inspected and flagged before being inputted into ChatGPT. All responses by ChatGPT were qualified utilizing the properties of natural coherence. Responses that were found to be incorrect were divided into the following categories: logical, informational, or explicit fallacy.

Results
ChatGPT answered a total of 242 questions with an accuracy of 54.96%. The software incorporated logical reasoning in 88.8% of questions, internal information in 95.5% of questions, and external information in 92.1% of questions. When stratified by correct and incorrect responses, we determined that there was a statistically significant difference in ChatGPT's use of external information (P &lt; .05).

Conclusions
ChatGPT is a versatile tool that has the potential to impact resident education by providing general knowledge, clarifying information, providing case-based learning, and promoting evidence-based medicine. With advancements in LLM and artificial intelligence (AI), it is possible that ChatGPT may be an impactful tool for resident education within Plastic Surgery.
VirPipe: an easy-to-use and customizable pipeline for detecting viral genomes from Nanopore sequencing
Authors: Kim Kijin , Park Kyungmin , Lee Seonghyeon , Baek Seung-Hwan , Lim Tae-Hun , Kim Jongwoo , Manavalan Balachandran , Song Jin-Won , Kim Won-Keun 
Published: May 2023

Summary

Detection and analysis of viral genomes with Nanopore sequencing has shown great promise in the surveillance of pathogen outbreaks. However, the number of virus detection pipelines supporting Nanopore sequencing is very limited. Here, we present VirPipe, a new pipeline for the detection of viral genomes from Nanopore or Illumina sequencing input featuring streamlined installation and customization.

Availability and implementation
VirPipe source code and documentation are freely available for download at https://github.com/KijinKims/VirPipe, implemented in Python and Nextflow.
Sex-dependent effects of acute stress on amyloid-β in male and female mice
Authors: Edwards Hannah M , Wallace Clare E , Gardiner Woodrow D , Doherty Brookelyn M , Harrigan Ryan T , Yuede Kayla M , Yuede Carla M , Cirrito John R 
Published: May 2023

Abstract
The risk of developing Alzheimer’s disease is mediated by a combination of genetics and environmental factors, such as stress, sleep abnormalities and traumatic brain injury. Women are at a higher risk of developing Alzheimer’s disease than men, even when controlling for differences in lifespan. Women are also more likely to report high levels of stress than men. Sex differences in response to stress may play a role in the increased risk of Alzheimer’s disease in women.
In this study, we use in vivo microdialysis to measure levels of Aβ in response to acute stress in male and female mice. We show that Aβ levels are altered differently between female and male mice (APP/PS1 and wild-type) in response to stress, with females showing significantly increased levels of Aβ while most males do not show a significant change. This response is mediated through β-arrestin involvement in Corticotrophin Releasing Factor receptor signalling pathway differences in male and female mice as male mice lacking β-arrestin show increase in Aβ in response to stress similar to females.
Synergetic process between wind power and sewage sludge pyrolysis in a novel renewable-energy microgrid system
Authors: Liu Chang , Zhuo Jiankun , He Yanfeng , Li Shuiqing , Yao Qiang 
Published: May 2023

AbstractTo relieve the stress of sewage sludge (SS) disposal and effectively increase the use of renewable energy, a novel renewable-energy microgrid system (REMS) was developed, specifically designed to integrate a wind power plant (WPP) with energy storage and the SS pyrolysis process for heat and power generation. Based on a lab-scale pyrolysis experiment and 7-day numerical analysis, we studied the energy-recycling potential of SS and simulated the operational behaviours of REMS. According to the results, the calorific values of the pyrolytic gaseous and liquid products were better than those of the raw material, at 16.19 and 33.53 MJ/kg, respectively. The proposed REMS performed well in power supply and energy utilization with a design performance index of 99.23 when the WPP capacity was 200 MWe and the initial wind-energy curtailment rate was 30%. It indicates that by converting SS into flammable gas, condensable liquid and carbon-rich solid residue, curtailed wind energy could be saved and the synergy between wind power and the SS pyrolysis process enabled the proposed microgrid system to effectively utilize renewable energy and provide reliable on-demand power service. The REMS installed with a 155-MWe WPP achieved the optimal design in system performance, environmental benefit and construction cost under the initial wind-curtailment rate of 34.12%. The design scheme makes REMS capable of satisfying the 15.10-GWh power demand of end users and the 1700-t/day SS disposal need, and the curtailed wind energy could be reduced to zero.
Do temperature changes cause eczema flares? An English cohort study
Authors: Chan Jonathan , MacNeill Stephanie J , Stuart Beth , Lo Y T Eunice , Roberts Amanda  , Mitchell Dann , Ridd Matthew J 
Published: May 2023

Abstract

Background
It is unclear if ambient temperature changes affect eczema. It is also unclear if people with worse disease are more susceptible to weather-related flares, or specific types of emollient offer protection.

Objectives
To investigate the effect of short-term temperature variations on eczema symptoms in children.

Methods
Data from a UK cohort of 519 children with eczema were combined with data from the Hadley Centre’s Integrated Surface Database. Hot and cold weeks were defined by average regional temperature &gt; 75th or &lt; 25th percentile, January 2018 to February 2020. Eczema flares were defined as ≥ 3-point change in Patient-Oriented Eczema Measure (POEM). Random-effects logistic regression models were used to estimate the odds ratios of flares in hot and cold weeks (reference group: temperate weeks).

Results
The baseline mean age was 4.9 years (SD 3.2) and the POEM score was 9.2 (SD 5.5). From the 519 participants, there were 6796 consecutively paired POEMs and 1082 flares. Seasonal variation in POEM scores was observed, suggesting symptoms worsening in winter and improving in summer. Odds ratios of flares were: 1.15 [95% confidence interval (CI) 0.96–1.39, P = 0.14] in cold weeks and 0.85 (95% CI 0.72–1.00, P = 0.05) in hot weeks. The likelihood ratio test showed no evidence of this differing by disease severity (P = 0.53) or emollient type used (P = 0.55).

Conclusions
Our findings are consistent with previous studies demonstrating either improvements in eczema symptoms or reduced flares in hot weather. Worse disease and different emollient types did not increase susceptibility or provide protection against temperature changes. Further work should investigate the role of sunlight, humidity, pollution and other environmental factors.
Capability of Children with Hearing Devices: A Mixed Methods Study
Authors: Rijke Wouter J , Vermeulen Anneke M , Willeboer Christina , Knoors Harry E T , Langereis Margreet C , van der Wilt Gert Jan 
Published: May 2023

Abstract
We investigated 34 deaf and hard-of-hearing children with hearing devices aged 8–12 years and 30 typical hearing peers. We used the capability approach to assess well-being in both groups through interviews. Capability is “the real freedom people have to do and to be what they have reason to value.” Speech perception, phonology, and receptive vocabulary data of the deaf and hard-of-hearing children, that were used retrospectively, showed a large variability. The analysis of the relation between clinical quantitative outcome measures and qualitative capability interview outcomes suggests that at this age, differences in clinical performance do not appear to translate into considerable differences in capability, including capability did offer insight into the factors that appeared to ensure this equivalence of capability. We argue that capability outcomes should be used to determine the focus of (auditory) rehabilitation and support, in line with the United Nations Convention on the Rights of the Child.
Ostial stenosis of reimplanted left main coronary artery and supravalvular pulmonary stenosis: a case report of two complications of surgery for anomalous left coronary artery from the pulmonary artery
Authors: Alghamdi Fatima Abdullah , Shah Muhammad Azam , Alshalash Saleh , Alkhodair Abdullah Mohammed 
Published: May 2023

Abstract

Background
Anomalous origin of the coronary artery from the pulmonary artery (ALCAPA) is a rare congenital disease. Surgical re-implantation of the left main coronary artery (LMCA) to the aorta is a definitive treatment with a good prognosis.

Case summary
A 9-year-old boy was admitted with a complaint of exertional chest pain and dyspnoea. At 13 months of age, he was diagnosed to have ALCAPA as a workup of severe left ventricular systolic dysfunction and underwent coronary re-implantation of ALCAPA. Coronary angiogram displayed the high takeoff of re-implanted LMCA with significant ostial stenosis, and echocardiogram showed significant supravalvular pulmonary stenosis (SVPS) with a peak gradient of 74 mmHg. After a multidisciplinary team discussion, he underwent percutaneous coronary intervention with stenting to ostial LMCA. On follow-up, he was asymptomatic and a cardiac computed tomography scan showed a patent stent in LMCA with an under-expanded area in the mid-segment. The proximal part of the LMCA stent was located very close to the stenotic segment of the main pulmonary artery making it a high risk for balloon angioplasty. The surgical intervention of SVPS is delayed to allow the somatic growth of the patient.

Discussion
Percutaneous coronary intervention in re-implanted LMCA is a feasible option. If stenosis of re-implanted LMCA is accompanied by SVPS, the latter can be best treated surgically and staged to decrease the operative risk. Our case also demonstrates the importance of long-term follow-up of post-operative complications of patients with ALCAPA.
Police Response Time and Injury Outcomes
Authors: DeAngelo Gregory , Toger Marina , Weisburd Sarit 
Published: May 2023

Abstract
The delayed response of law enforcement to calls for service has become a hot button issue when evaluating police department performance. While it is often assumed that faster response times could play an important role in quelling potentially violent incidents, there is no empirical evidence to support this claim. In this paper, we measure the effect of police response time on the likelihood that an incident will result in an injury. To overcome the endogeneity of more severe calls being assigned higher priority, which requires a faster response, we take several steps. First, we focus on the subset of calls for service categorised as ‘Major Disturbance—Violence’ that all receive the same priority level. Second, we instrument for police response time with the number of vehicles within a 2.5-mile radius of the incident at the time it is received by the call centre. When controlling for beat, month and time-of-day fixed effects, this instrumenting strategy allows us to take advantage of the geographical constraints faced by a dispatcher when assigning officers to an incident. In contrast to the ordinary least squares estimates, our two-stage least squares analysis establishes a strong causal relationship whereby increasing response time increases the likelihood that an incident results in an injury. The effect is concentrated among female victims, suggesting that faster response time could potentially play an important role in reducing injuries related to domestic violence.
Severity of Brugada syndrome disease manifestation and risk of new-onset depression or anxiety: a Danish nationwide study
Authors: Jespersen Camilla H B , Krøll Johanna , Bhardwaj Priya , Winkel Bo Gregers , Jacobsen Peter Karl , Jøns Christian , Haarbo Jens , Kristensen Jens , Johansen Jens Brock , Philbert Berit T , Riahi Sam , Torp-Pedersen Christian , Køber Lars , Tfelt-Hansen Jacob , Weeke Peter E 
Published: May 2023

Abstract

Aims
Reduced psychological health is associated with adverse patient outcomes and higher mortality. We aimed to examine if a Brugada syndrome (BrS) diagnosis and symptomatic disease presentation were associated with an increased risk of new-onset depression or anxiety and all-cause mortality.

Methods and results
All Danish patients diagnosed with BrS (2006–2018) with no history of psychiatric disease and available for ≥6 months follow-up were identified using nationwide registries and followed for up to 5 years after diagnosis. The development of clinical depression or anxiety was evaluated using the prescription of medication and diagnosis codes. Factors associated with developing new-onset depression or anxiety were determined using a multivariate Cox proportional hazards regression model. Disease manifestation was categorized as symptomatic (aborted cardiac arrest, ventricular tachycardia, or syncope) or asymptomatic/unspecified at diagnosis. A total of 223 patients with BrS and no history of psychiatric disease were identified (72.6% male, median age at diagnosis 46 years, 45.3% symptomatic). Of these, 15.7% (35/223) developed new-onset depression or anxiety after BrS diagnosis (median follow-up 5.0 years). A greater proportion of symptomatic patients developed new-onset depression or anxiety compared with asymptomatic patients [21/101 (20.8%) and 14/122 (11.5%), respectively, P = 0.08]. Symptomatic disease presentation (HR 3.43, 1.46–8.05) and older age (lower vs. upper tertile: HR 4.41, 1.42–13.63) were significantly associated with new-onset depression or anxiety. All-cause mortality in this group of patients treated according to guidelines was low (n = 4, 1.8%); however, 3/4 developed depression or anxiety before death.

Conclusion
Approximately, one-sixth of patients with BrS developed new-onset depression or anxiety following a diagnosis of BrS. Symptomatic BrS disease manifestation was significantly associated with new-onset depression or anxiety.
The evolutionary demise of a social interaction: experimentally induced loss of traits involved in the supply and demand of care
Authors: Bladon Eleanor K , Pascoal Sonia , Bird Nancy , Mashoodh Rahia , Kilner Rebecca M 
Published: May 2023

Abstract
Phenotypic plasticity enables animals to adjust their behavior flexibly to their social environment—sometimes through the expression of adaptive traits that have not been exhibited for several generations. We investigated how long social adaptations can usefully persist when they are not routinely expressed, by using experimental evolution to document the loss of social traits associated with the supply and demand of parental care. We allowed populations of burying beetles Nicrophorus vespilloides to evolve in two different social environments for 48 generations in the lab. In “Full Care” populations, traits associated with the supply and demand of parental care were expressed at every generation, whereas in “No Care” populations we prevented expression of these traits experimentally. We then revived trait expression in the No Care populations at generations 24, 43, and 48 by allowing parents to supply post-hatching care and compared these social traits with those expressed by the Full Care populations. We found that offspring demands for care and male provision of care in the No Care populations were lost sooner than female provision of care. We suggest that this reflects differences in the strength of selection for the expression of alternative traits in offspring, males and females, which can enhance fitness when post-hatching care is disrupted.
Structural and functional diversity of bacterial cyclic nucleotide perception by CRP proteins
Authors: Krol Elizaveta , Werel Laura , Essen Lars Oliver , Becker Anke 
Published: May 2023

Abstract
Cyclic AMP (cAMP) is a ubiquitous second messenger synthesized by most living organisms. In bacteria, it plays highly diverse roles in metabolism, host colonization, motility, and many other processes important for optimal fitness. The main route of cAMP perception is through transcription factors from the diverse and versatile CRP–FNR protein superfamily. Since the discovery of the very first CRP protein CAP in Escherichia coli more than four decades ago, its homologs have been characterized in both closely related and distant bacterial species. The cAMP-mediated gene activation for carbon catabolism by a CRP protein in the absence of glucose seems to be restricted to E. coli and its close relatives. In other phyla, the regulatory targets are more diverse. In addition to cAMP, cGMP has recently been identified as a ligand of certain CRP proteins. In a CRP dimer, each of the two cyclic nucleotide molecules makes contacts with both protein subunits and effectuates a conformational change that favors DNA binding. Here, we summarize the current knowledge on structural and physiological aspects of E. coli CAP compared with other cAMP- and cGMP-activated transcription factors, and point to emerging trends in metabolic regulation related to lysine modification and membrane association of CRP proteins.