bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Lupinus luteus on hepatic and renal extracellular compounds turnover under diabetes in rat
Authors: Sayari Maha , Dab Houcine , Tlili Mounira , Zourgui Lazhar , Khabir Abdelmajid 
Published: December 2022

AbstractHepatic and renal extracellular matrix (ECM) turnover associated with diabetes and potential beneficial effects of yellow lupin extract (YLE) need further investigations. The aim of this study was to explore the effect of yellow Lupinus luteus extract (YLE) on renal and hepatic ECM under diabetes. Composition of YLE performed by LC‐ESI‐MS. Diabetes (DM) was induced in rats by alloxan (250 mg/kg, ip). Normal and diabetic rats received 100 mg/kg of YLE for 1 month. ECM was assessed by ELISA. Gelatinases and collagenases were analyzed by a colorimetric assay. Histology was performed on sections of liver and kidney. In the liver, diabetes increases collagen, laminin, and fibronectin contents, respectively, by 49% (p < .01), 56% (p < .01), and 67% (p < .05) compared to control rats. In the kidney, total collagen and laminin contents were increased by 91% (p < .01) and 35% (p < .01) in the DM group, while fibronectin content in diabetic animals and those treated with YLE remains similar to the control group. Collagenases and gelatinases activities were significantly increased by diabetes in liver and kidney. While YLE treatment abrogates diabetes‐enhanced MMPs activities in liver. In diabetic rats, the liver shows signs of diffuse dilatation of the sinusoid veins and steatosis. However, the liver of diabetic rats treated with yellow lupine extract showed a normal histological aspect similar to controls. Diabetes causes hepatic and renal ECM turnover. YLE can be useful to partially improve tissue disorders induced by diabetes.
Mid‐ to Late Holocene landscape dynamics and rural settlement in the uplands of northern Bavaria, Germany
Authors: Kothieringer Katja , Seregély Timo , Jansen Doris , Steup Raphael , Schäfer Andreas , Lambers Karsten , Fuchs Markus 
Published: December 2022

AbstractWe present results from a systematic interdisciplinary study on (pre‐)historic rural settlement and landscape development in an upland region of northern Bavaria, Germany. The archaeological and geoarchaeological investigations—supported by radiocarbon dating, optically stimulated luminescence dating, and palaeoecological analysis—were performed to (i) identify so far unknown prehistoric rural settlement sites, (ii) determine site‐specific soil erosion from colluvial deposits, and (iii) assess the composition of woodland from on‐ and offsite charcoal finds. The earliest indicators of human activities from the Younger Neolithic (late 5th to early 4th millennium B.C.E.) come from colluvial deposits. Our investigations, for the first time, show Middle to Late Bronze Age (ca. 1400–800 B.C.E.), permanent rural settlement in a German central upland region, with a peak in the Late Bronze Age. Due to the varying thicknesses of Bronze Age colluvial deposits, we assume land use practices to have triggered soil erosion. From the spectrum of wood species, Maloideae, ash, and birch are regarded as successional indicators after fire clearance in that period. Settlement continued until the 5th century B.C.E. After a hiatus of 500 years, it re‐flourished in the Late Roman and Migration periods (mid‐3rd–5th century C.E.) and went on in the Medieval period.
Solid‐State Confinement Effects in Selective exo‐H/D Exchange in the Rhodium σ‐Norbornane Complex [(Cy2PCH2CH2PCy2)Rh(η2:η2‐C7H12)][BArF4]
Authors: Krämer Tobias , Chadwick F. Mark , Macgregor Stuart A. , Weller Andrew S. 
Published: December 2022

AbstractDensity functional theory calculations modelling selective exo‐H/D exchange observed in the Rh σ‐alkane complex [(Cy2PCH2CH2PCy2)Rh(η2:η2‐endo‐NBA)][BArF4], [1‐NBA][BArF4], are reported, where ArF=3,5‐C6H3(CF3)2 and NBA=norbornane, C7H12. Two models were considered 1) an isolated molecular cation, [1‐NBA]+ and 2) a full model in which [1‐NBA][BArF4] is treated in the solid state through periodic DFT. After an initial endo‐exo rearrangement, both models predict H/D exchange to proceed through D2 addition and oxidative cleavage followed by a rate‐limiting C−H activation of the norbornane through a σ‐CAM step to form a [1‐Rh(D)(η2‐HD)(norbornyl)]+ intermediate. HD rotation followed by a σ‐CAM C−D bond formation, HD reductive coupling and HD loss then complete the H/D exchange process. exo‐H/D exchange is facilitated by a supporting agostic interaction and is consistently more accessible kinetically than the potentially competing endo‐H/D exchange (isolated cation: ΔG≠exo=+15.9 kcal/mol, ΔG≠endo=+18.4 kcal/mol; solid state: ΔG≠exo=+22.1 kcal/mol, ΔG≠endo=+25.1 kcal/mol). The solid‐state environment has a significant impact on the computed energetics, with barriers increasing by ca. 7 kcal/mol, while only the solid‐state model correctly predicts the endo‐bound NBA complex to be the resting state of the system. These outcomes reflect solid‐state confinement effects within the pocket occupied by the [1‐NBA]+ cation and defined by the pseudo‐octahedral array of neighbouring [BArF4]− anions. The asymmetry of the solid‐state environment also requires a second H/D exchange pathway to be defined to account for reaction at all four exo‐C−H bonds. These entail slightly higher barriers (ΔG≠exo=+24.8 kcal/mol, ΔG≠endo=+27.5 kcal/mol) but retain a distinct preference for exo‐ over endo‐H/D exchange.
Treatment progress of cryptozoospermia with Western Medicine and traditional Chinese medicine: A literature review
Authors: Liu Huang , Luo Zefang , Chen Jinghua , Zheng Houbin , Zeng Qingqi 
Published: December 2022

AbstractBackground and AimsCryptozoospermia is an extreme oligozoospermia with an unsatisfactory treatment effect, with an incidence rate of approximately 8.73% in male infertility, whose effective solution has become the call of the times. Western Medicine has achieved certain effects through drugs, surgery, and assisted reproductive therapy, but this is still not ideal. Traditional Chinese medicine (TCM) has made many achievements in other disciplines; however, there is still a lack of evidence‐based medical evidence to improve sperm production.MethodsThe relevant literatures from the China National Knowledge Internet (CNKI) and PubMed in the past 10 years were collected in this article, of which the mechanisms, advantages, or current controversies of various treatment methods of Western Medicine and TCM were analyzed, to find new treatment methods and research directions.ResultsWith the development of modern science and technology, medical treatments for cryptozoospermia have become increasingly abundant; however, there is still no universally recognized unified and effective guiding plan. Although TCM has not been fully verified by evidence‐based medicine, most TCM combined with Western Medicine can achieve unexpected results.ConclusionThe combination of TCM and Western Medicine may become a bane for cryptozoospermia and bring good news to infertile men worldwide.
Experimental investigation of solar‐powered food steamer based on parabolic dish concentrator for domestic applications
Authors: Kumar Vikrant , M. Chandrashekara , Yadav Avadhesh 
Published: December 2022

AbstractSteam cooking is beneficial over other cooking techniques like boiling since it preserves more vitamins lost during other methods. In this study, a novel solar food steamer (SFS) based on a parabolic dish concentrator (PDC) is designed and constructed for domestic food preparation. A straightforward fabrication process of a 2.626 m2 PDC with design calculations is also presented. The system's instantaneous energy and exergy efficiency evaluation has been examined from different tests over three consecutive days. The system's high energetic and exergetic efficiency was achieved in the case of sweet potato, that is, 72.83% and 15.14%, respectively. In the case of dried chickpeas, the maximum steaming duration of 70 min was attained, along with an energy efficiency of 47.74% and an exergy efficiency of 10.07%. In addition, an economic analysis was performed to determine the payback time in terms of cost and utility. The payback time for the proposed method is 2.4 years. The SFS may save 43 kg/month of carbon dioxide from escaping into the atmosphere; it can be considered an environmentally valuable device.
Corporate governance and financial distress: A review of the theoretical and empirical literature
Authors: Yousaf Umair Bin , Jebran Khalil , Ullah Irfan 
Published: December 2022

AbstractThis study comprehensively reviews the theoretical and empirical literature on the relationship between corporate governance and financial distress and provides future research directions. We follow several different approaches by identifying, reviewing, and classifying related articles during the period 1985 to 2021. We used a set of keywords that included a combination of different terms of corporate governance and financial distress. Our review indicates that the majority of the studies based their arguments considering a single theory. The generalizability of different results in less explored countries is a serious concern and the one‐size‐fits‐all approach does not apply to the corporate governance‐financial distress relationship. Several different theories and confounding factors need consideration when examining the relationship between corporate governance and financial distress. Our review highlights future avenues by suggesting that studies should consider different governance attributes and test those factors in different and diverse contexts. Our review of the literature provides implications for academics and practitioners.
Circularly polarized luminescence of lanthanide complexes: From isolated individuals, discrete oligomers, to hierarchical assemblies
Authors: Zhong Yuan , Wu Zhennan , Zhang Yu , Dong Bin , Bai Xue 
Published: December 2022

AbstractCircularly polarized luminescence (CPL) is the emission featured spatial orientation equivalent to circular dichroism. Owning to the unique magnetic dipole‐allowed but electric‐dipole‐forbidden 4f→ 4ftransitions, chiral lanthanide complexes have been recognized as ideal candidates to achieve unprecedented luminescence dissymmetry factor (glum). Their inherent electric‐dipole‐forbidden transition can be partly allowed, through the rational design of coordination ligands to lower the surrounding symmetry, further endowing them with relatively high quantum yields (QYs). Moreover, the blossom of supramolecular chemistry in lanthanide complexes allows for the construction of discrete oligomers and hierarchical assemblies, rendering them with enhanced chiroptical activities. Here, we deploy this review by summarizing recent advances in the chiroptical properties of lanthanide complexes, spanning multiple scales from isolated mononuclear individuals, discrete polynuclear oligomers, to infinite hierarchical assemblies. We first introduce the basic concept and several important parameters for the assessment of CPL activity. Then, isolated mononuclear lanthanide complexes coordinated with different types of antennas, along with the unique chirality transfer and induction in achiral lanthanide complexes were discussed. Next, the systematical discussion on chiroptical properties in discrete polynuclear lanthanide oligomers and infinite hierarchical lanthanide assemblies was presented. Meanwhile, the state‐of‐the‐art applications of CPL‐active lanthanide complexes were revisited. We end up this review with the conclusion and prospects, involving the rational design of ligands, directed and hierarchically precise self‐assembly, and extending applications of chiral lanthanide complexes.image
Geographical variations in outreach of information and communication technology and rural development in West Bengal, India
Authors: Satpati Sandip , Sharma Kaushal Kumar 
Published: December 2022

AbstractThe article investigates the Geographical variations in the outreach of information and communication technology (ICT) diffusion and its effects on rural development across 341 Community Development (CD) blocks of West Bengal. The study is based on secondary data. Secondary data has been collected from Districts Statistical Handbook, Primary Census Abstract, District Census Handbook, and Socio‐Economic and Caste Census. The principal component analysis technique has been used for ICT diffusion index calculation. ArcMap 10.1 has been used for Mapmaking to understand the spatial intensity of the ICT index. The study finds that West Bengal falls within the least zone (0.07–0.18) of ICT diffusion in India due to multi‐dimensional socio‐economic factors. Only 35 CD blocks out of 341 are located in the high ICT diffusion zone (0.49–0.79) in West Bengal, which is 6.87 percent area to the total area. The study concluded that the higher the ICT diffusion higher is the rural development in West Bengal. The study recommends that the government invest more money in ICT in rural development.
LIPG is a novel prognostic biomarker and correlated with immune infiltrates in lung adenocarcinoma
Authors: Wang Shan , Chen Zhaoxin , Lv Hongwei , wang Cong , Wei Huamin , Yu Jing 
Published: December 2022

AbstractBackgroundAlthough many biomarkers for lung adenocarcinoma (LUAD) have been identified, their specificity and sensitivity remain unsatisfactory. Endothelial lipase gene (LIPG) plays an important role in a variety of cancers, but its role in lung adenocarcinoma remains unclear.MethodsTCGA, GEO, K‐M plotter, CIBERSORT, GSEA, HPA, and GDSC were used to analyze LIPG in LUAD. Data analysis was mainly achieved by R 4.0.3.ResultsThe expression of LIPG in LUAD tissues was higher than that in adjacent normal tissues, especially in women, patients aged >65 years, and those with lymph node metastasis. High expression predicted a poor prognosis. The results of enrichment analysis suggest that LIPG may exert profound effects on the development of LUAD through multiple stages of lipid metabolism and immune system regulation. In addition, LIPG expression was significantly correlated with the expression levels of multiple immune checkpoint genes and the abundance of multiple immune infiltrates, including the activated memory CD4 T cell, M1 macrophage, neutrophil, plasma cells, and T follicular helper (Tfh) cells in the LUAD microenvironment content. At the same time, patients with high LIPG expression respond well to a variety of antitumor drugs and have a low rate of drug resistance.ConclusionsLIPG is a prognostic marker and is associated with lipid metabolism and immune infiltration in LUAD.
Emotional wellbeing and coping among Latinx young adults in the time of COVID‐19
Authors: Wagner Kevin M. , Chatham Ana A. , Prado Kimberly , Walsdorf Ashley A. , Villatoro Alice P. , Garcia Deliana , de Snyder Nelly Salgado , Valdez Carmen R. 
Published: December 2022

AbstractThe COVID‐19 pandemic has disrupted the wellbeing of the general US population, but even more so among Latinx young adults. The current study provides a detailed picture of the emotional wellbeing and coping of Latinx young adults during the first summer of the pandemic. Six virtual focus groups (n = 21) were conducted between May and August of 2020 with a community‐based sample of Latinx young adults to explore (1) how the pandemic affected wellbeing and (2) how they coped with pandemic‐related stress. Contextualistic thematic analysis identified important themes and subthemes. Perceived stressors impacting emotional wellbeing yielded one overarching theme: COVID‐related disruptions in the participants' environment. To manage this heightened stress, another overarching theme was self‐care and intentionality during the pandemic. Future studies should examine the wellbeing of young adults across social contexts and at more recent stages of the pandemic. Findings from this study suggest culturally‐ and developmentally‐tailored interventions are needed as this population navigates contextual stress during a sensitive period in their life.
Infectivity of pseudotyped SARS‐CoV‐2 variants of concern in different human cell types and inhibitory effects of recombinant spike protein and entry‐related cellular factors
Authors: Zhang George Fei , Meng Wen , Chen Luping , Ding Ling , Sun Shenyu , Wang Xian , Huang Yufei , Guo Haitao , Gao Shou‐Jiang 
Published: December 2022

AbstractSince the report of the first COVID‐19 case in 2019, SARS‐CoV‐2 variants of concern (VOCs) have continued to emerge, manifesting diverse infectivity, evasion of host immunity and pathology. While ACE2 is the predominant receptor of SARS‐CoV‐2, TMPRSS2, Kim‐1, NRP‐1, CD147, furin, CD209L, and CD26 have also been implicated as viral entry‐related cofactors. To understand the variations in infectivity and pathogenesis of VOCs, we conducted infection analysis in human cells from different organ systems using pseudoviruses of VOCs including Alpha, Beta, Gamma, and Delta. Recombinant spike S1, RBD, ACE2, Kim‐1, and NRP‐1 proteins were tested for their ability to block infection to dissect their roles in SARS‐CoV‐2 entry into cells. Compared with wild type SARS‐CoV‐2 (WT), numerous VOCs had significant increases of infectivity across a wide spectrum of cell types. Recombinant ACE2 protein more effectively inhibited the infection of VOCs including Delta and Omicron (BA.1 and BA.2) than that of WT. Interestingly, recombinant S1, RBD, Kim‐1, and NRP‐1 proteins inhibited the infection of all pseudoviruses in a manner dependent on the levels of ACE2 expression in different cell types. These results provide insights into the diverse infectivity of SARS‐CoV‐2 VOCs, which might be helpful for managing the emergence of new VOCs.
Event‐based precipitation characteristics related to cloud‐top temperature during pre‐summer rainy season over south China
Authors: Zhang Aoqi , Chen Yilun , Li Weibiao , Chen Shumin 
Published: December 2022

AbstractPrecipitation exists in the form of event, which means all pixels within the same event have similar atmospheric condition and development experiences. Therefore, using GPM DPR and Himawari‐8 AHI data from 2016 to 2020, we carried out event‐based investigations on precipitations during the pre‐summer rainy season over south China. The identified rain clusters (RCs) were classified into three classes based on the mode of cloud‐top temperature, including those <230, 230–265, and >265 K. The results show that RCs with mode of cloud‐top temperature <230 K were related to low‐level velocity and jet. The atmospheric layer was very unstable with sufficient moisture supply, so the ratio of convective precipitation reached as high as 20% with largest droplet size. RCs at 230–265 K were mainly frontal stratiform precipitations caused by quasi‐stationary front. The atmospheric layer was stable but the horizontal moisture flux was strong; precipitations often appeared as continuous light rain with high droplet density and small droplet size. RCs with mode of cloud‐top temperature >265 K contributed less than 10% of the accumulated rainfall amount. They were mainly warm‐cloud shallow precipitations triggered by local convection with low droplet density. Our results suggest that the event‐scale characteristics of precipitation are indicative of the triggers and microphysics of precipitation.
Posttraumatic stress disorder symptom trajectories in a 16‐month COVID‐19 pandemic period
Authors: López‐Castro Teresa , Papini Santiago , Bauer Alexandria , Swarbrick Margaret , Paul Lynn K. , Nizzi Marie‐Christine , Stanley Damian , Team COVID‐Dynamic , Hien Denise 
Published: December 2022

AbstractCOVID‐19 pandemic presents an unheralded opportunity to better understand trajectories of posttraumatic stress disorder (PTSD) symptoms across a prolonged period of social disruption and stress. We tracked PTSD symptoms among trauma‐exposed individuals in the United States and sought to identify population‐based variability in PTSD symptom trajectories and understand what, if any, early pandemic experiences predicted membership in one trajectory versus others. As part of a longitudinal study of U.S. residents during the pandemic, participants who reported at least one potentially traumatic experience in their lifetime (N = 1,206) at Wave 1 (April 2020) were included in the current study. PTSD symptoms were assessed using the PCL‐5 at four time points extending to July 2021. Latent growth mixture modeling was used to identify heterogeneous symptom trajectories. Trajectory membership was regressed on experiences from the early stage of the pandemic as measured using the Epidemic‐Pandemic Impacts Inventory in a model that controlled for variables with documented associations to PTSD trajectories, including age, sex, income, and trauma history. Four trajectories were identified, categorized as resilient (73.0%), recurring (13.3%), recovering (8.3%), and chronic (5.5%). Emotional and physical health problems and positive changes associated with the early phase of the pandemic were each significant predictors of trajectory membership over and above all other variables in the model. Predictors primarily differentiated the resilient trajectory from each of the other three trajectories. Distinct PTSD symptom trajectories during the COVID‐19 pandemic suggest a need for targeted efforts to help individuals at most risk for ongoing distress.
Dynamic rheological properties of sesame protein dispersions
Authors: Rafe Ali , Seddighi Ramesh , Mousavi Maryam , Bastan Ensieh 
Published: December 2022

AbstractInterest in utilizing new sustainable protein sources is increasing, and understanding the rheological behavior of sesame protein can be useful in further application. Small amplitude oscillatory shear measurements of sesame protein dispersions at varying concentrations of 5.0%, 7.5%, and 10.0% were examined at both linear and nonlinear regions. Although the sesame protein dispersions showed pseudoplastic behavior, the shear‐thickening effect of sesame proteins at higher concentrations makes it possible to apply in beverages without increasing viscosity. The low values of the yield point of the sesame protein explained its feasibility for utilization in varying products such as high‐protein‐enriched beverages without the adverse effect of the high viscosity. The fracture stress and strain indicated the high strength of the sesame protein to the mechanical changes. The mechanical properties of the sesame proteins also confirmed typical strong gel behavior. The complex viscosity (η*) was decreased linearly with frequency demonstrating the shear thinning phenomenon. The frequency dependency of the protein was shown a low n value that explains a relatively elastic gel structure. These rheological characteristics of the sesame proteins might be more reliable than the previous works on the static rheological behavior, which provides a new horizon in the application of a sustainable protein in food industries.