bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of microbubbles and temperature on the germination of the saltmarsh plant, Suaeda maritima (L.) Dumort
Authors: Lee Na Young , Xing Qikun , Park Ji-Sook , Park Young Cheol , Yarish Charles , Kim Jang Kyun 
Published: July 2023

Abstract
Background
Temperature and dissolved gas availability are important parameters for the germination of saltmarsh plants. As a newly developed method to increase the dissolved gas availability, microbubble technology has shown to increase the crop production. However, the effects of microbubbles on the germination of saltmarsh plants have not been studied. The aim of this study is to investigate the effects of the microbubbles on the germination of Suaeda maritima (L.) Dumort. in different temperatures (6, 12, 18, 24 and 30ºC).
Results
The highest germination rate was observed at 24 ºC in MBs water. The germination rates at microbubbles were significantly higher than those at control, deionized water at 24 ºC. The germination energy was significantly higher at 24 and 30 ºC than at 6 and 12 ºC in both deionized and microbubbles waters. The mean germination time was significantly shorter at 24 and 30 ºC than at 6 and 12 ºC in both waters. However, no significant effects of microbubbles were observed in terms of germination energy and mean germination time.
Conclusion
This study suggests that microbubbles improves the germination rate of S. maritima at the optimal temperature (24ºC), but GE and MGT were not affected by microbubbles but by temperature in S. maritima.
Mental Foramen Position in Class I, II, III Malocclusion on Vertical and Horizontal Dimensions by using CBCT
Authors: Jamilian Abdolreza , Nucci Ludovica , Talaeipour Ahmadreza , Nikkho Neda , Farjaminejad Rosana , Mafi Reza 
Published: July 2023

Abstract
Purpose: Mental foramen (MF) is characterised as a funnel-like opening of the mental canal onto the lateral surface of mandible, it serves as a pathway for vessels and nerves.The present study aimed to determine the position of the mental foramen (MF) in CBCT images in Class I, Class II, and Class III malocclusions with different growth patterns.
Material and Methods: In this descriptive-cross-sectional study, 150 CBCT images of individuals with Class I, Class II, and Class III malocclusions were selected. Each sagittal malocclusion had 50 samples, with 25 participants exhibiting a vertical growth pattern and 25 participants exhibiting a horizontal growth pattern for each type of malocclusion.The age range was 18-35 years, and they had no history of specific oral and dental diseases, previous surgeries, or orthodontic treatment. Using CBCT images, measurements were performed on both the left and right sides. MF Shape and MF Position relative to the Nearest Tooth were evaluated. And also MF Length, Hieght, Distance from MF to Inferior Border, Distance from MF to Bone Crest and Mental Canal Angle were measured. The variables of different types of malocclusions were evaluated using one-way analysis of variance (ANOVA). The frequency of MF shape and its position in relation to the nearest tooth, were analysed by using the chi-square test.
Results: No significant differences were observed in terms of shape of MF among different types of malocclusion in sagittal relationship and type of growth pattern. Significant differences in location of MF were observed in terms of growth pattern P=0/0028. However there was not any significant changes in location of MF in sagittal malocclusions. The distance from MF to the inferior border (p<0.001), distance to the crest of the bone (p<0.001), and mental canal angle (p=0.008) were significantly greater in individuals with a vertical growth pattern compared to those with horizontal growth pattern. Distance of MF to inferior border of mandible was 15/96± 0/63 in class II vertical growth pattern which was higher than in class I and II vertical growers. And also the same distance in class II horizontal growers was 13/56± 0/89 which was greater than in class I and II horizontal growers.
Conclusion:
Greater distance between the mental foramen (MF) and the inferior border of the mandible was observed in Class II vertical growth pattern compared to Class I and Class II vertical growers. Similarly, in Class II horizontal growers, the distance was higher compared to Class I and Class II horizontal growers of MF to inferior border of mandible was greater in class II vertical growth pattern in relationship to class I and II vertical growers. And the same distance in class II horizontal growers was higer than in class I and II horizontal growers.
Low Anterior Resection Syndrome And Quality Of Life Of Patients Post Sphincter Preservation Surgery: A Prospective Study
Authors: K Chandramohan , Jacob Akhil Thomas , Muralee Madhu , Sudam Wagh Mira , L Mayadevi , Balakrishnan Sithara 
Published: July 2023

Abstract
Background
Post AR one of the most debilitating syndrome is low anterior resection syndrome (LARS) seen in about 64% of patients. Severity of the LARS score was significantly correlated with neoadjuvant treatment, the extent of rectal surgery, complication by anastomotic leak, female gender and age < 64. In this study we had analysed the impact of various clinical factors on LARS and also the various domains of quality of life.
Purpose
To assess incidence of LARS in patients undergoing sphincter sparing surgery for rectal cancer after the patient starts long term defecating per anus, change in the quality of life and relation to LARS and factors affecting it
Methods
72 patients who had undergone anterior resection in Regional Cancer, one year before were interviewed by the trained interviewer and data was collected from the file. The questionnaires used :Wexner Incontinence Score, LARS Malayalam Questionnaire, EORTC QLQ C30 Malayalam translations.
Statistical measures
The LARS score was used to categorise patients into 3 grades. The scores were compared with clinical and social factors using the χ2 test for association. Continuous variables were compared by the Spearman Rho test.
Results
Details of patients were studied, (male: 55.6 % & female:44.4%) . 50 patients underwent low Anterior resection. Mean LARS score was 25.61, with 47.2% of patients having severe LARS score. Mean Wexner score was 6.84. The relation with type of surgery, approach (laparoscopic vs open), or type of neoadjuvant therapy were not found to be significant. Higher LARS score did not impact overall QoL as assessed by FACT-C. Insomnia and diarrhoea symptoms scores were significantly worsened. Pain score was worse for those undergoing stapler anastomosis. Wexner's score was worse for those who had received adjuvant chemotherapy. Role functioning score was better for AR compared to low anterior resection. Only distance from anal verge was found to be a significant cause of LARS and was negatively correlated
Discussion
LARS of severe degree were seen in most patients. No modifiable risk factors were significantly found to affect the chance of LARS. But LARS did not have a significant impact on quality of life, neither did the type of surgery. So sphincter preservation can be offered to the patients, but all patients undergoing Low Anterior Resection should be counselled well about the risk of LARS before surgery.
The SNP rs460089 in the gene promoter of the drug transporter OCTN1 has prognostic value for treatment-free remission in chronic myeloid leukemia patients treated with imatinib
Authors: Polakova Katerina Machova , Albeer Ali , Polivkova Vaclava , Krutska Monika , Vlcanova Katerina , Curik Nikola , FABARIUS Alice , Klamova Hana , Spieß B , Waller Cornelius , Bruemmendorf Tim , Dengler Jolanta , Kunzmann Volker , Burchert Andreas , Belohlavkova Petra , Mustjoki Satu , Faber Edgar , Mayer Jiri , Zackova Daniela , Panayiotidis Panayiotis , Richter Johan , Hjorth-Hansen Henrik , Kamińska Magdalena , Płonka Magdalena , Szczepanek Elżbieta , Szarejko Monika , Bober Grażyna , Hus Iwona , Grzybowska-Izydorczyk Olga , Wasilewska Ewa , Paczkowska Edyta , Niesiobędzka-Krężel Joanna , Giannopoulos Krzysztof , Mahon Francois-Xavier , Sacha Tomasz , Saussele Susanne , Pfirrmann Markus 
Published: July 2023

Abstract
Membrane transporters are important determinants of drug bioavailability. Their expression and activity affect the intracellular drug concentration in leukemic cells impacting response to therapy. Pharmacogenomics represents genetic markers that reflect allele arrangement of genes encoding drug transporters associated with treatment response. In previous work, we identified SNP rs460089 located in the promotor of SLC22A4 gene encoding imatinib transporter OCTN1 as influential on response of patients with chronic myeloid leukemia treated with imatinib. Patients with rs460089-GC pharmacogenotype had significantly superior response to first-line imatinib treatment compared to patients with rs460089-GG.
This study investigated whether pharmacogenotypes of rs460089 are associated with sustainability of treatment-free remission (TFR) in patients from the EUROpean Stop Kinase Inhibitor (EURO-SKI) trial. In the learning sample, 176 patients showed a significantly higher 6-month probability of molecular relapse free survival (MRFS) in patients with GC genotype (73%, 95% CI: 60-82%) compared to patients with GG (51%, 95% CI: 41-61%). Also over time, patients with GC genotype had significantly higher MRFS probabilities compared with patients with GG (HR: 0.474, 95% CI: 0.280-0.802, p=0.0054). Both results were validated with data on 93 patients from the Polish STOP imatinib study. The SNP rs460089 was found as an independent predictor of TFR.
Single-cell-based sequencing reveals that CD8+ T cells regulate SGK1 expression in psoriasis
Authors: Dong Canbin , Lin Lanmei , Du Juan 
Published: July 2023

Abstract
Background Psoriasis is an autoimmune disease mediated by T cells. Downregulation of SGK1 is known to exacerbate psoriasis. However, the specific significance of SGK1 expression in psoriasis and the associated regulation of SGK1 remain unknown.
Methods Here, we performed a comprehensive analysis of the significance and impact of SGK1 expression.We obtained transcriptome expression profiles of skin lesions in 13 psoriasis patients from the original psoriasis-related dataset (GSE151177).Subpopulations of T cells and keratinocytes (KC) were first analyzed. The expression of SGK1 was utilized to identify the different functions of keratin-forming cells.Finally, the association between CD8 + T cells and cells expressing SGK1 was revealed by cellular interactions and validated by FISH.
Results Single-cell transcriptome analysis was performed using psoriasis lesion tissues from 13 cases in the database. Subpopulation analysis of T cells and keratinocytes (KC) was performed.We found that CD8 + T cells have characteristics of tissue-resident memory T cells and are involved in the proliferative differentiation of KC.Different SGK1 expression levels were found to have different physiological functions in KC analysis.Analysis of intercellular reciprocal communication indicated that CD8 + T cells may intervene in keratinocyte and monocyte-macrophage SGK1 expression through CCL/TIGIT signaling.FISH showed that SGK1 was widely distributed in the infiltration sites of CD8 + T cells, suggesting a potential relationship between CD8 + T cells and SGK1 expression.
Conclusion The above results show that CD8 + T cells upregulate SGK1 expression in keratinocytes and monocyte macrophages mainly through TIGIT signaling, a process that is inhibited in psoriasis.
Supratentorial hemangioblastomas: differences in phenotypes are correlated with the anterior vs. the posterior cerebral circulations
Authors: Laviv Yosef , Saraf David , Oxman Liat , Zvi Ido Ben 
Published: July 2023

Abstract
Background
Supratentorial hemangioblastomas (ST HB) are rare, vascular lesions. The presence of peri-tumoral cysts and edema has meaningful clinical, diagnostic and therapeutic implications. Nevertheless, the pathogenesis of both cyst and edema formation is not fully understood.
Aim
to investigate whether the radiologic phenotype of ST HB is affected by the different cerebral arterial circulations.
Material and methods
We have reviewed the published English literature over the last 5 decades (January 1973 to January 2023). 73 cases of parenchymal ST HB were eligible for analysis. The cohort was divided into two groups based on the vascular territory distribution of the lesions: anterior circulation (group 1, n = 52) vs. posterior circulation (group 2, n = 21). The two subgroups were compared for demographic, clinical, radiological and molecular variables.
Results
On univariate analysis, male gender and cystic changes were associated with HB of the posterior circulation (OR = 3.61, p = 0.024 and OR = 4.85, p = 0.01; respectively). On the other hand, significant peritumoral edema and parasagittal/paramedian location were associated with the anterior circulation (OR = 0.18, p = 0.05 and OR = 0.30, p = 0.036; respectively). On multivariate analysis, cystic changes have remained significantly associated with the posterior circulation, while the association of significant peritumoral edema with the anterior circulation has nearly reached statistical significance (OR = 5.47, p = 0.008 and OR = 0.25, p = 0.054). The incidence of von-Hippel Lindau (vHL) disease was nearly two-fold higher in group 1. In group 2, all (100%, n = 7) female patients had cystic tumors, compared to only 30.7% (n = 8) of female patients in the anterior circulation group (OR = 32.647, 95% CI 1.665 to 640.016; p = 0.0217).
Conclusion
based on historical cases of ST HB, we were able to show that different tumor phenotypes are associated with the different cerebral circulations. In addition, gender was also associated with differences in tumor’s distribution as well as radiologic phenotype. Together, this novel data may influence our understanding on other unique vascular diseases of the central nervous system.
The singular complex integro differential equation via the boundary value problems of elastic plate weakened by curvilinear hole
Authors: Ibrahim E. , Abdou M. A. 
Published: July 2023

Abstract

In this paper, we presented an integro differential equation (IDE), in compelx plane, with singular kernel. The IDE is investigated from the first and second boundary value problem (BVP) of a weakened infinite plate by a curvilinear hole (C,) in the presence of heat. The hole is conformally mapped inside a unit circle by a special transformation with complex constants coefficients\(z=\omega (\zeta ),\,\zeta =\xi +i\eta ,\,i=\sqrt { - 1} .\) This mapping will conform the curvilinear hole in the infinite elastic plate into a unit circle \(\gamma ,\left| \zeta \right|\;<\,\,1,\) such that inside the circle. The stress and strain compounds were calculated, in the presence of heat effect, and this was clarified by numerical results. Many applications for the problem are discussed. Maple 2019 is used for computations results.
MSC (2010): 74B10, 30C20.
An archaeal lid-containing feruloyl-esterase degrades polyethylene terephthalate (PET)
Authors: Streit Wolfgang , Perez-Garcia Pablo , Chow Jennifer , Costanzi Elisa , Gurschke Marno , Dittrich Jonas , Dierkes Robert , Applegate Violetta , Feuerriegel Golo , Tete Prince , Danso Dominik , Schumacher Julia , Pfleger Christopher , Gohlke Holger , Smits Sander , Schmitz Ruth , Molitor Rebecka , Thies Stephan , Jaeger Karl-Erich 
Published: July 2023

Abstract
Polyethylene terephthalate (PET) is a commodity polymer known to globally contaminate marine and terrestrial environments. Today, around 80 bacterial and fungal PET-active enzymes (PETases) are known, originating from four bacterial and two fungal phyla. In contrast, no archaeal enzyme has been identified to degrade PET. Here we report on the structural and biochemical characterization of PET46, an archaeal promiscuous feruloyl esterase exhibiting degradation activity on semi-crystalline PET powder comparable to IsPETase and LCC (wildtypes), and higher activity on bis-, and mono-(2-hydroxyethyl) terephthalate (BHET and MHET). The enzyme, found by a sequence-based metagenome search, was derived from a non-cultivated, deep-sea Candidatus Bathyarchaeota archaeon. Biochemical characterization demonstrated that PET46 is a promiscuous, heat-adapted hydrolase. Its crystal structure was solved at a resolution of 1.71 Å. It shares the core alpha/beta-hydrolase fold with bacterial PETases, but contains a unique lid common in feruloyl esterases, which is involved in substrate binding. Thus, our study widens the currently known diversity of PET-hydrolyzing enzymes, by demonstrating PET depolymerization by a plant cell wall-degrading esterase.
The Prediction of diffuse large B-cell lymphoma by a Novel Glycolysis-Related Gene Signature
Authors: Qi Yujiao , Da Dezhuan , Yang Bingbing , He Yang , Li Hongling , Liu Congcong 
Published: July 2023

Abstract
Objectives
Globally, diffuse large B-cell lymphoma (DLBCL) accounts for approximately 30–40% of all cases of non-Hodgkin's lymphoma. There is often rapid enlargement of a single or multiple external nodes or nodules in patients. glycolysis is the process by which glucose transporters on the cell membrane transport glucose into the cell to split into two molecules of pyruvate. The large amounts of lactic acid produced by glycolysis are secreted extracellular to create an acidic microenvironment. This change leads to the remodeling of the cell matrix, which is essential for tumor cell proliferation. To date, only a few studies have attempted to determine whether glycolysis plays a prognostic role in DLBCL.
Methods
On DLBCL patients, we gathered RNA-seq data and clinical details from the TCGA and GEO databases. Based on glycolysis genes, we divided them into two clusters by consensus clustering method. The two discovered clusters were compared for survival, function, and tumor microenvironments (TME) using the K-M survival analysis, ESTIMATE, TIMER, and ssGSEA analysis. A variety of methods were used to elucidate the mechanisms involved, including GO, KEGG, GSVA, and GSEA. Utilizing the LASSO tool and multivariate Cox regression analysis, a predictive risk model for genes associated to glycolysis was formed, and its value was verified by calibration and ROC curve.
Results
As shown by the K-M survival curve and Tumor microenvironment analysis both clusters had significantly difference. the survival rate, Immune Score, Stromal Score and ESTIMATE Score of the C1 cluster was substantially higher than the C2 cluster. GO and KEGG analysis indicated that DEGs between the two clusters tended to be enriched in extracellular matrix and immune pathways. It was suggested by GSVA and GSEA analyses that glycolysis-associated genes (GRGs) expression perhaps connected to immunosuppression and poor prognosis in DLBCL patients. With DLBCL, factors such as risk models and clinical features can be combined to accurately predict a patient's prognosis.
Conclusion
Patients with DLBCL exhibit glycolysis-related gene expression that predicts their prognosis, as well as the tumor microenvironment.
Haze Prediction Method Based On Stacking Learning
Authors: Liu Zuhan , Liu Xuehu , Zhao Kexin 
Published: July 2023

Abstract
In recent years, with the rapid economic development of our country, environmental problems have become increasingly prominent, especially air pollution has more and more affected People's daily life. Air pollution is mobile and can cause long-term effects over large areas, which are detrimental to the natural environment and human body. Haze is a form of air pollution, which comprises PM2.5 components that adversely impair human health. Multiple approaches for predicting PM2.5 in the past have had limited accuracy, meanwhile required vast quantities of data and computational resources. In order to tackle the difficulties of poor fitting effect, large data demand, and slow convergence speed of prior prediction techniques, a PM2.5 prediction model based on the stacking integration method is proposed. This model employs eXtreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM) and Random Forest (RF) as the base model, while ridge regression is used as the meta-learner to stack. PM2.5 concentration is influenced by a variety of pollutant factors and meteorological factors, and the correlation between PM2.5 concentration and other factors was analyzed using Spearman's correlation coefficient method. Several significant factors that determine the haze concentration are selected out, and the stacking model is built on this data for training and prediction. The experimental results indicate that the fusion model constructed in this thesis can provide accurate PM2.5 concentration estimates with fewer data features. This approach performs better in terms of accuracy and time consumption.
Parameter orthogonality transformations in distributional regression models
Authors: Stadlmann Stanislaus , Heller Gillian , Kneib Thomas , Koens Lyndon 
Published: July 2023

Abstract
Distributional regression has become an increasingly popular tool in regression analysis, providing the ability to link distributional parameters beyond the mean to additive predictors. For many response distributions, maximum likelihood estimates (MLEs) of the distributional parameters are correlated and, as a result, misspecifying the regression predictor for one distributional parameter induces a bias in the estimates for the predictors of other parameters, even if these are correctly specified. In this article we develop a framework for the reparametrization of any two-parameter distribution, such that its parameters have asymptotically uncorrelated MLEs i.e., are orthogonal. We propose to retain the location parameter and replace the second parameter of the chosen distribution with a function that provides a numeric solution to an ordinary differential equation (ODE) based on the covariance matrix of the MLEs, creating an orthogonal parametrization. Finally, our proposed method is demonstrated on an extreme rainfall dataset from Tasmania, Australia.
U.S. Official Visits and Foreign Aid
Authors: Kodila-Tedika Oasis , Khalifa Sherif 
Published: July 2023

Abstract
This paper examines the effect of the visits by U.S. officials to a country on foreign aid. To achieve our objective, we compile variables that indicate the official visits of U.S. Presidents and Secretaries of States from 1960-2019 from the historical archives of the U.S. State Department. We examine the effect of these variables on U.S. aid and total official development assistance flows to the country. To deal with potential endogeneity, we use the Endogenous Treatment Model. The estimation results show that the visits of U.S. officials have a statistically significant positive effect on U.S. aid only when the visit is part of a multilateral meeting, while the effect of the visits of U.S. Presidents have a statistically significant positive effect on total official development assistance only when the visit is in the form of a bilateral meeting. A potential interpretation is that U.S. aid is provided as part of a multilateral effort intended to induce other countries to provide assistance to the country as well. However, donors could take the flow of U.S. aid as a signal that the country will be able to secure aid from the U.S. and will be less in need of their assistance. On the other hand, a bilateral visit by an American President can signal to other donors the confidence the United States have in this country, the close ties it has with this country, or the stakes it has in preserving stable economic conditions in this country. This could induce the donors to aid the country by offering official development assistance.
JEL Code: D72, F54, F35, H11, O19