bluuebunny/crossref_metadata_2025_split huggingface dataset:
A propensity score matching study on survival benefits of radiotherapy in patients with inoperable hepatocellular carcinoma
Authors: Zeng Hao , Su Ke , Chen Xiaojing , Li Xueting , Wen Lianbin , Song Yanqiong , Chen Lan , Li Han , Guo Lu , Han Yunwei 
Published: April 2023

AbstractWith the advancements in radiotherapy (RT) in recent years, several studies have shown that RT can significantly prolong the survival of patients with hepatocellular carcinoma (HCC). As a noninvasive treatment option, the application of RT for the treatment of HCC is garnering increasing attention. In this retrospective study, we included data from 13,878 patients with HCC from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2019 and 325 patients with HCC treated in three tertiary hospitals in China between 2015 and 2021. Patient data were divided into RT and non-RT groups based on whether the patients underwent RT. Propensity score matching analysis was performed to minimize the deviation between the RT and non-RT groups, and the Kaplan–Meier method, Cox proportional hazard model, and nomogram were used to assess the efficacy of undergoing RT. The median overall survival (mOS) of the RT group was significantly longer compared with that of the non-RT group for the SEER data (16 months versus 9 months, p < 0.01). Similarly, the survival benefit was more significant in the RT group than in the non-RT group at our hospitals (34.1 months versus 15.4 months, p < 0.01). Furthermore, multivariate Cox analysis revealed that factors, including tumor (T) stage, patient age, tumor grade, serum AFP level, and chemotherapy, also affected patient survival. Moreover, these factors were also used to construct a nomogram. Subgroup analysis of these factors showed that RT was effective in prolonging patient survival in different populations. RT significantly improves the survival time of patients with inoperable HCC, thereby providing a basis for selecting HCC patients who can benefit from RT.
Perceived barriers to early presentation and symptom-specific time to seek medical advice for possible colorectal cancer symptoms among Palestinians
Authors: Elshami Mohamedraed , Ayyad Mohammed , Hamdan Fatma Khader , Alser Mohammed , Al-Slaibi Ibrahim , Naji Shoruq Ahmed , Mohamad Balqees Mustafa , Isleem Wejdan Sudki , Shurrab Adela , Yaghi Bashar , Qabaja Yahya Ayyash , Dwikat Mohammad Fuad , Sweity Raneen Raed , Jneed Remah Tayseer , Assaf Khayria Ali , Albandak Maram Elena , Hmaid Mohammed Madhat , Awwad Iyas Imad , Alhabil Belal Khalil , Alarda Marah Naser , Alsattari Amani Saleh , Aboyousef Moumen Sameer , Aljbour Omar Abdallah , AlSharif Rinad , Giacaman Christy Teddy , Alnaga Ali Younis , Nemer Ranin Mufid Abu , Almadhoun Nada Mahmoud , Skaik Sondos Mahmoud , Abu-El-Noor Nasser , Bottcher Bettina 
Published: April 2023

AbstractThis study explored the anticipated time to seek medical advice for possible colorectal cancer (CRC) signs/symptoms and its association with CRC symptom awareness. In addition, it examined perceived barriers that may delay seeking medical advice. Palestinian adults were recruited from hospitals, primary healthcare centers, and public spaces in 11 governorates. A modified, translated-into-Arabic version of the validated Bowel Cancer Awareness Measure was used. The questionnaire comprised three sections: sociodemographics, assessment of CRC symptom awareness and time to seek medical advice, and barriers to early presentation. A total of 4623 participants were included. The proportion that reported seeking immediate medical advice for possible CRC signs/symptoms with blood or mass ranged from 47.1% for ‘blood in stools’ to 59.5% for ‘bleeding from back passage’. Less than half of the participants reported immediate seeking of medical advice for non-specific symptoms (ranging from 5.4% for ‘loss of appetite’ to 42.0% for ‘anemia’) and other gastrointestinal symptoms (ranging from 7.7% for ‘feeling persistently full’ to 35.7% for ‘change in bowel habits’). Good CRC symptom awareness was associated with higher likelihood of seeking medical advice within a week from recognizing a CRC symptom. About 13.0% reported a delay to visit their doctor after recognizing a CRC symptom. The most reported barriers were practical with ‘would try some herbs first’ (50.9%) as the leading barrier. CRC symptoms with blood or mass prompted earlier help seeking. Participants with good CRC awareness were more likely to seek medical advice within a week.
Relationship between antidementia medication and fracture prevention in patients with Alzheimer’s dementia using a nationwide health insurance claims database
Authors: Hosoi Tatsuya , Yakabe Mitsutaka , Matsumoto Shoya , Fujimori Kenji , Tamaki Junko , Nakatoh Shinichi , Ishii Shigeyuki , Okimoto Nobukazu , Kamiya Kuniyasu , Akishita Masahiro , Iki Masayuki , Ogawa Sumito 
Published: April 2023

AbstractThis retrospective study aimed to evaluate the association between antidementia medication use and incidence of new vertebral, hip, and radial fractures in patients with Alzheimer’s dementia (AD). We used the nationwide health insurance claims database of Japan from 2012 to 2019 and identified 12,167,938 patients aged ≥ 65 years who were newly registered from April 2012 to March 2016 and had verifiable data receipt from half-year before to 3 years after the registration. Among these patients, 304,658 were diagnosed with AD and we showed the prescription status of antidementia and osteoporosis medication among them. Propensity score matching was conducted for AD group with and without antidementia medication use, and 122,399 matched pairs were yielded. The incidence of hip fractures (4.0% vs. 1.9%, p < 0.001) and all clinical fractures (10.5% vs. 9.0%, p < 0.001) significantly decreased and that of radial fractures increased (0.6% vs. 1.0%, p < 0.001) in AD patients with antidementia medication use compared with AD patients without antidementia medication use. No significant difference was found in vertebral fractures (6.6% vs. 6.5%, p = 0.51). Overall, these results suggest a positive relationship between antidementia medication use and fracture prevention in patients with AD.
Global trends in research related to the links between microbiota and antibiotics: a visualization study
Authors: Zyoud Sa’ed H. , Shakhshir Muna , Abushanab Amani S. , Koni Amer , Taha Adham Abu , Abushamma Faris , Sabateen Ali , Al-Jabi Samah W. 
Published: April 2023

AbstractThe scientific community widely acknowledges that the gut microbiota plays a critical role in maintaining host health and can be altered by a range of factors, such as antibiotic use, diet, stress, and infections. Therefore, this study utilized bibliometric analysis to thoroughly investigate research trends in the microbiota and antibiotics. Scopus was used to extract papers linked to microbiota and antibiotics published between 2002 and 2021, and both Microsoft Excel and VOSviewer were used to conduct the analysis of the data. A total of 2,816 publications discussed the connection between the microbiota and antibiotics. Growth occurred in two stages: the first (2002–2015) was characterized by fairly slow publication production, while the second (2016–2021) saw a rapid increase in publishing progress. The United States has the most publications, 654, representing 23.22% of the total. China came second with 372 publications (13.21%), followed by the United Kingdom with 161 publications (5.72%) and India with 157 publications (5.58%). In addition, publications on ‘altered intestinal microbiota composition with antibiotic treatment’ were introduced after 2017, while ‘gut microbiota and antimicrobial resistance’ and ‘probiotics as an alternative antimicrobial therapy’ were introduced before 2017. Based on these results, this study provides an in-depth look at key moments in the history of microbiota and antibiotic research, as well as possible directions for future research in different areas of microbiota and antibiotic research. Therefore, it is suggested that more attention should be given to the latest promising hotspots, such as how antibiotic treatment changes the composition of the gut microbiota.
Filming enhanced ionization in an ultrafast triatomic slingshot
Authors: Howard Andrew J. , Britton Mathew , Streeter Zachary L. , Cheng Chuan , Forbes Ruaridh , Reynolds Joshua L. , Allum Felix , McCracken Gregory A. , Gabalski Ian , Lucchese Robert R. , McCurdy C. William , Weinacht Thomas , Bucksbaum Philip H. 
Published: April 2023

AbstractFilming atomic motion within molecules is an active pursuit of molecular physics and quantum chemistry. A promising method is laser-induced Coulomb Explosion Imaging (CEI) where a laser pulse rapidly ionizes many electrons from a molecule, causing the remaining ions to undergo Coulomb repulsion. The ion momenta are used to reconstruct the molecular geometry which is tracked over time (i.e., filmed) by ionizing at an adjustable delay with respect to the start of interatomic motion. Results are distorted, however, by ultrafast motion during the ionizing pulse. We studied this effect in water and filmed the rapid “slingshot” motion that enhances ionization and distorts CEI results. Our investigation uncovered both the geometry and mechanism of the enhancement which may inform CEI experiments in many other polyatomic molecules.
Accelerated quantum Monte Carlo with probabilistic computers
Authors: Chowdhury Shuvro , Camsari Kerem Y. , Datta Supriyo 
Published: April 2023

AbstractQuantum Monte Carlo (QMC) techniques are widely used in a variety of scientific problems and much work has been dedicated to developing optimized algorithms that can accelerate QMC on standard processors (CPU). With the advent of various special purpose devices and domain specific hardware, it has become increasingly important to establish clear benchmarks of what improvements these technologies offer compared to existing technologies. In this paper, we demonstrate 2 to 3 orders of magnitude acceleration of a standard QMC algorithm using a specially designed digital processor, and a further 2 to 3 orders of magnitude by mapping it to a clockless analog processor. Our demonstration provides a roadmap for 5 to 6 orders of magnitude acceleration for a transverse field Ising model (TFIM) and could possibly be extended to other QMC models as well. The clockless analog hardware can be viewed as the classical counterpart of the quantum annealer and provides performance within a factor of < 10 of the latter. The convergence time for the clockless analog hardware scales with the number of qubits as ∼ N, improving the ∼ N2 scaling for CPU implementations, but appears worse than that reported for quantum annealers by D-Wave.
Rapid grain boundary diffusion in foraminifera tests biases paleotemperature records
Authors: Adams Arthur , Daval Damien , Baumgartner Lukas P. , Bernard Sylvain , Vennemann Torsten , Cisneros-Lazaro Deyanira , Stolarski Jarosław , Baronnet Alain , Grauby Olivier , Guo Jinming , Meibom Anders 
Published: April 2023

AbstractThe oxygen isotopic compositions of fossil foraminifera tests constitute a continuous proxy record of deep-ocean and sea-surface temperatures spanning the last 120 million years. Here, by incubating foraminifera tests in 18O-enriched artificial seawater analogues, we demonstrate that the oxygen isotopic composition of optically translucent, i.e., glassy, fossil foraminifera calcite tests can be measurably altered at low temperatures through rapid oxygen grain-boundary diffusion without any visible ultrastructural changes. Oxygen grain boundary diffusion occurs sufficiently fast in foraminifera tests that, under normal upper oceanic sediment conditions, their grain boundaries will be in oxygen isotopic equilibrium with the surrounding pore fluids on a time scale of <100 years, resulting in a notable but correctable bias of the paleotemperature record. When applied to paleotemperatures from 38,400 foraminifera tests used in paleoclimate reconstructions, grain boundary diffusion can be shown to bias prior paleotemperature estimates by as much as +0.86 to −0.46 °C. The process is general and grain boundary diffusion corrections can be applied to other polycrystalline biocarbonates composed of small nanocrystallites (<100 nm), such as those produced by corals, brachiopods, belemnites, and molluscs, the fossils of which are all highly susceptible to the effects of grain boundary diffusion.
Southern California winter precipitation variability reflected in 100-year ocean salinity record
Authors: Byrne Sierra M. , Merrifield Mark A. , Carter Melissa L. , Cayan Daniel R. , Flick Reinhard E. , Gershunov Alexander , Giddings Sarah N. 
Published: April 2023

AbstractRainfall in southern California is highly variable, with some fluctuations explainable by climate patterns. Resulting runoff and heightened streamflow from rain events introduces freshwater plumes into the coastal ocean. Here we use a 105-year daily sea surface salinity record collected at Scripps Pier in La Jolla, California to show that El Niño Southern Oscillation and Pacific Decadal Oscillation both have signatures in coastal sea surface salinity. Averaging the freshest quantile of sea surface salinity over each year’s winter season provides a useful metric for connecting the coastal ocean to interannual winter rainfall variability, through the influence of freshwater plumes originating, at closest, 7.5 km north of Scripps Pier. This salinity metric has a clear relationship with dominant climate phases: negative Pacific Decadal Oscillation and La Niña conditions correspond consistently with lack of salinity anomaly/ dry winters. Fresh salinity anomalies (i.e., wet winters) occur during positive phase Pacific Decadal Oscillation and El Niño winters, although not consistently. This analysis emphasizes the strong influence that precipitation and consequent streamflow has on the coastal ocean, even in a region of overall low freshwater input, and provides an ocean-based metric for assessing decadal rainfall variability.
Engineering a non-noble plasmonic center in MOF-derived Z-scheme heterojunctions for enhanced photoelectrochemical water splitting
Authors: Li Chuanping , Hang Tianxiang , Zhou Hui , Ge Ping , Li Shuoren , Zhu Xian-Dong 
Published: April 2023

A plasmonic Z-scheme catalyst is designed by the in situ derivation of NH2-MIL-125 and oxygen-vacancy engineering. The catalyst exhibits superior water oxidation activity in the PEC water splitting applications.
Identification of PPT1 as a lysosomal core gene with prognostic value in hepatocellular carcinoma
Authors: Tian Wei , Li Chenyu , Ren Jiaqi , Li Pengfei , Zhao Jingyuan , Li Shuai , Dong Deshi 
Published: April 2023

Abstract
Hepatocellular carcinoma (HCC) is the most frequent cancer worldwide with a poor prognosis. Unfortunately, there are few reports on effective biomarkers for HCC, identification of novel cancer targets is urgently needed. Lysosomes are central organelles for degradation and recycling processes in cells, and how lysosome-related genes are involved in the progression of hepatocellular carcinoma remains unclear. The aim of the present study was to identify key lysosome-related genes affecting HCC. In the present study, lysosome-related genes involved in HCC progression were screened based on the TCGA (The Cancer Genome Atlas) dataset. Differentially expressed genes (DEGs) were screened, and core lysosomal genes were obtained in combination with prognostic analysis and protein interaction networks. Two genes were associated with survival, and their prognostic value was validated by prognostic profiling. After mRNA expression validation and IHC, the palmitoyl protein thioesterase 1 (PPT1) gene was identified as an important lysosomal-related gene. We demonstrated that PPT1 promotes the proliferation of HCC cells in vitro. In addition, quantitative proteomics and bioinformatics analysis confirmed that PPT1 acts by affecting the metabolism, localization, and function of various macromolecular proteins. The present study reveals that PPT1 could be a promising therapeutic target for the treatment of HCC. These findings provided new insights into HCC and identified candidate gene prognosis signatures for HCC.
Georacial Epidemiological Estimates of Glucose-6-Phosphate Dehydrogenase Deficiency among Newborns in the United States
Authors: Vidavalur Ramesh , Bhutani Vinod K. 
Published: April 2023

Objective Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is the most common inherited enzyme deficiency disorder worldwide and a major risk factor for the development of severe hyperbilirubinemia. Racial diversity of phenotypes and genotypes in affected individuals is likely to exist in the United States because of changing population demographics. The aim of the present study was to predict an empirical estimate of annual prevalence of G6PDd in newborns adjusted for geography (state of birth), maternal racial identity, and sex of the infant.
Study Design Birth statistics (2019) from National Center for Vital Statistics and CDC-WONDER data and race-specific prevalence of G6PDd in the United States were evaluated from published sources. We developed Simpson's diversity index (DI) for each State and correlated these to rates of G6PDd in neonates. Descriptive statistics including modeled prevalence and its association with DI were assessed using the Spearman's rho correlation test. We modeled state-specific prevalence for six states (California, Washington DC, Illinois, Massachusetts, New York, and Pennsylvania) using population-level allele frequencies and race, based on Hardy–Weinberg equilibrium.
Results We estimated 78,010 (95% confidence interval: 76,768–79,252) newborns had G6PDd at birth in 2019 with cumulative median prevalence of 17.3 (interquartile range: 12.4–23.2) per 1,000 live births for United States. A strong association was noted for DI and prevalence of G6PDd (p < 0.0005). Five states (Washington DC, Mississippi, Louisiana, Georgia, and Maryland) have the highest projected G6PDd prevalence, with a range of 35 to 48 per 1,000 live births. The probability of G6PDd for female heterozygotes, based on male prevalence, ranged from 1.1 to 7.5% for each cohort in the select six states.
Conclusion States with diverse populations are likely to have higher rates of G6PDd. These prevalence estimates exceeded by several-fold when compared with disorders screened by existing state mandated newborn screening panels. These discrepancies are further confounded by known risk of severe neonatal hyperbilirubinemia that results with G6PDd and the life-long risk of hemolysis. Combined universal newborn predischarge screening for G6PDd and bilirubin could alert and guide a clinician's practices for parental education and closer medical surveillance during the vulnerable neonatal time period.
Key Points
Pharmacy Students' Knowledge and Attitudes about Homeopathy: A Descriptive Survey Conducted in Turkey
Authors: Renda Gülin , Gökkaya İçim , Kandemir Gamze , Özyiğit Tuğçe , Kurt Tuğba 
Published: April 2023

Abstract
Background Homeopathy belongs to “Traditional and Complementary Medicine” (TCM) and is defined in the TCM regulation in Turkey as a holistic practice method that aims to improve health status with personalized medicines. The international and national literature includes a limited number of studies that examine individuals' knowledge, attitudes and behaviors toward homeopathy. Although in Turkey the Regulation on Pharmacists and Pharmacies states that the sale of homeopathic medicines is allowed only in pharmacies, no study was found that evaluated awareness about homeopathy among pharmacy students.
Objective The present study aims to assess pharmacy students' knowledge and attitudes toward homeopathy and to identify the factors that influence them.
Methods This descriptive study was conducted between December 1, 2021 and February 1, 2022 among the students of the Faculty of Pharmacy, Karadeniz Technical University (KTU), through a face-to-face survey. In total, 418 questionnaires suitable for data quality were included in the study. The SPSS 23.0 statistical program was used to analyze the data and the statistical significance level was taken as p < 0.05.
Results It was determined that 73% of the participants had heard about TCM practices and 55% had heard of homeopathy. Students in the fifth grade (p = 0.0001) and those working in an income-generating job (p = 0.026) were found to be those most aware of homeopathy. The students of the Faculty of Pharmacy correctly knew the basic working principles of homeopathy (p = 0.002). The source from which students obtained the most information about homeopathy was undergraduate courses. 80.4% of the participants thought that homeopathy should be applied by pharmacists. 47.0% of the students wanted to learn more about homeopathy or to carry out studies in the field of homeopathy in their careers.
Conclusion The results of this research revealed a high awareness amongst KTU pharmacy students about the practice of homeopathy.
Enhanced Clinical Decision-Making and Delivery of Minimally Invasive Care Using the ICCMS4D Integrated with Hands-Free Fluorescence-Based Loupes and a Chemomechanical Caries Removal Agent
Authors: Hiltch Gal , Steier Liviu , de Figueiredo José Antonio Poli 
Published: April 2023

AbstractThe purpose of this case report was to evaluate an approach for enhanced clinical decision-making while providing minimally invasive treatment, using the combined International Caries Classification and Management System (ICCMS 4D) with hands-free fluorescence-enhanced loupes (Reveal, Designs for Vision Inc., New York City, NY, United States) and a chemo-mechanical caries removal agent (Papacárie Duo Gel, Formula & Acao, Sao Paulo, Brazil). In recent decades, a shift towards a conservative approach to caries management has developed. The use of adequate operative techniques and correct decision-making are of paramount importance for early caries detection and tooth-preserving operative care. The use of noninvasive fluorescence-based adjuncts for enhanced diagnostic accuracy has gained popularity. Fluorescence describes the absorption of photons by a molecule, followed by its partial emission at a longer wavelength. Fluorescence detection of bacterial activity is largely based on the red/orange fluorescence emanating from bacterial metabolism, and has been shown to be found particularly in active caries and mature anaerobic plaque. The combined approach of using the standardized visual International Caries Detection and Assessment System (ICDAS) with fluorescence as an operative adjunct was shown to enhance the advantages of both systems. The approach may potentially increase detection sensitivity without compromising the specificity of the visual tactile method. A recent hands-free device is aimed to combine simultaneous diagnosis and therapy (theragnosis) using fluorescence, while overcoming possible obstacles to workflow continuity. The “Reveal” fluorescence-enhanced loupes are fitted with a dual white light/fluorescence light, and are said to allow the clinician to conduct any operational procedure with optional fluorescence guidance, from detection to caries removal, to treatment completion. Using the described method, a comprehensive pathway that emphasizes evidence-based information, correct clinical decision-making, and a minimally invasive therapeutic approach was proposed. The approach may represent a potential advancement in providing minimally invasive caries care.