bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning for predicting breast-conserving surgery candidates after neoadjuvant chemotherapy based on DCE-MRI
Authors: Chen Zhigeng , Huang Manxia , Lyu Jianbo , Qi Xin , He Fengtai , Li Xiang 
Published: August 2023

PurposeThis study aimed to investigate a machine learning method for predicting breast-conserving surgery (BCS) candidates, from patients who received neoadjuvant chemotherapy (NAC) by using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) obtained before and after NAC.Materials and methodsThis retrospective study included 75 patients who underwent NAC and breast surgery. First, 3,390 features were comprehensively extracted from pre- and post-NAC DCE-MRIs. Then patients were then divided into two groups: type 1, patients with pathologic complete response (pCR) and single lesion shrinkage; type 2, major residual lesion with satellite foci, multifocal residual, stable disease (SD), and progressive disease (PD). The logistic regression (LR) was used to build prediction models to identify the two groups. Prediction performance was assessed using the area under the curve (AUC), accuracy, sensitivity, and specificity.ResultsRadiomics features were significantly related to breast cancer shrinkage after NAC. The combination model achieved an AUC of 0.82, and the pre-NAC model was 0.64, the post-NAC model was 0.70, and the pre-post-NAC model was 0.80. In the combination model, 15 features, including nine wavelet-based features, four Laplacian-of-Gauss (LoG) features, and two original features, were filtered. Among these selected were four features from pre-NAC DCE-MRI, six were from post-NAC DCE-MRI, and five were from pre-post-NAC features.ConclusionThe model combined with pre- and post-NAC DCE-MRI can effectively predict candidates to undergo BCS and provide AI-based decision support for clinicians with ensured safety. High-order (LoG- and wavelet-based) features play an important role in our machine learning model. The features from pre-post-NAC DCE-MRI had better predictive performance.
Axillary lymph node dissection versus radiotherapy in breast cancer with positive sentinel nodes after neoadjuvant therapy (ADARNAT trial)
Authors: Garcia-Tejedor Amparo , Ortega-Exposito Carlos , Salinas Sira , Luzardo-González Ana , Falo Catalina , Martinez-Pérez Evelyn , Pérez-Montero Héctor , Soler-Monsó M. Teresa , Bajen Maria-Teresa , Benitez Ana , Ortega Raul , Petit Anna , Guma Anna , Campos Miriam , Plà Maria J. , Pernas Sonia , Peñafiel Judith , Yeste Carlos , Gil-Gil Miguel , Guedea Ferran , Ponce Jordi , Laplana Maria 
Published: August 2023

IntroductionBreast cancer surgery currently focuses on de-escalating treatment without compromising patient survival. Axillary radiotherapy (ART) now replaces axillary lymph node dissection (ALND) in patients with limited sentinel lymph node (SLN) involvement during the primary surgery, and this has significantly reduced the incidence of lymphedema without worsening the prognosis. However, patients treated with neoadjuvant systemic treatment (NST) cannot benefit from this option despite the low incidence of residual disease in the armpit in most cases. Data regarding the use of radiotherapy instead of ALND in this population are lacking. This study will assess whether ART is non-inferior to ALND in terms of recurrence and overall survival in patients with positive SLN after NST, including whether it reduces surgery-related adverse effects.Methods and analysesThis multicenter, randomized, open-label, phase 3 trial will enroll 1660 patients with breast cancer and positive SLNs following NST in approximately 50 Spanish centers over 3 years. Patients will be stratified by NST regimen and nodal involvement (isolated tumoral cells or micrometastasis versus macrometastasis) and randomly assigned 1:1 to ART without ALND (study arm) or ALND alone (control arm). Level 3 and supraclavicular radiotherapy will be added in both arms. The primary outcome is the 5-year axillary recurrence determined by clinical and radiological examination. The secondary outcomes include lymphedema or arm dysfunction, quality of life based (EORTC QLQ-C30 and QLQ-BR23 questionnaires), disease-free survival, and overall survival.DiscussionThis study aims to provide data to confirm the efficacy and safety of ART over ALND in patients with a positive SLN after NST, together with the impact on morbidity.Ethics and disseminationThe Research Ethics Committee of Bellvitge University Hospital approved this trial (Protocol Record PR148/21, version 3, 1/2/2022) and all patients must provide written informed consent. The involvement of around 50 centers across Spain will facilitate the dissemination of our results.Trial registrationClinicalTrials.gov, identifier number NCT04889924.
Cost-effectiveness analysis of once-daily oral semaglutide versus placebo and subcutaneous glucagon-like peptide-1 receptor agonists added to insulin in patients with type 2 diabetes in China
Authors: Feng Zhen , Tong Wai Kei , Zhang Xinyue , Tang Zhijia 
Published: August 2023

Introduction: Oral semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) that improves glycated hemoglobin levels and body weight in patients with type 2 diabetes (T2DM). We aim to evaluate the cost-effectiveness of once-daily oral semaglutide in comparison to placebo and injectable GLP-1 RAs in Chinese patients with T2DM inadequately controlled on basal insulin.Methods: The United Kingdom Prospective Diabetes Study Outcomes Model (UKPDS OM2.1) was used to estimate the cost-effectiveness by calculating the incremental cost-effectiveness ratio (ICER). Baseline characteristics of the simulation cohort were obtained from the PIONEER 8 trial. Utility and safety inputs were derived from a network meta-analysis of 12 trials. Direct medical costs were retrieved from published literature and discounted at an annual rate of 5%. We used a willingness-to-pay (WTP) threshold of $36,528.3 per quality-adjusted life-year (QALY) gained. Scenario analysis, and one-way and probabilistic sensitivity analysis were performed.Results: The effectiveness of oral semaglutide was 10.39 QALYs with a total cost of $30,223.10, while placebo provided 10.13 QALYs at a lower total cost of $20,039.19. Oral semaglutide was not cost-effective at an ICER of $39,853.22 and $88,776.61 per QALY compared to placebo and exenatide at the WTP. However, at an annual price of $1,871.9, it was cost-effective compared with dulaglutide, liraglutide, and lixisenatide. The model was most sensitive to the discount rate and annual cost of oral semaglutide. The price of oral semaglutide needed to be reduced to $1,711.03 per year to be cost-effective compared to placebo and other injectable GLP-1 RAs except for exenatide and semaglutide injection.Conclusion: We found that once-daily oral semaglutide, at a comparable price of semaglutide injection, proves to be a cost-effective add-on therapy to insulin for Chinese patients with T2DM, especially when compared to subcutaneous GLP-1 RAs other than injectable semaglutide and exenatide. However, to achieve cost-effectiveness in comparison to placebo, further cost reduction of oral semaglutide is necessary. The estimated annual cost of $1,711.03 for oral semaglutide demonstrates a more cost-effective option than placebo, highlighting its potential value in the management of T2DM.
Development of a robust UPLC-MS/MS method for the quantification of riluzole in human plasma and its application in pharmacokinetics
Authors: Sun Zhuo , Liu Xin , Zuo Wei , Fu Qiang , Xu Tingting , Cui Liying , Zhang Bo , Peng Ying 
Published: August 2023

Introduction: The aim of the present study was to establish a simple method for the determination of riluzole in human plasma by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and apply it for the determination of riluzole in amyotrophic lateral sclerosis (ALS) patients.Methods: Samples were prepared by protein precipitation and were then gradient-eluted on a column of ACQUITY UPLC® HSS T3 by using 0.1% formic acid acetonitrile and 0.1% formic acid water as the mobile phase. Detection was performed on a Xevo TQ-S tandem mass spectrometer in the multiple-reaction monitoring mode using positive electrospray ionization. Validation was performed in the range of 5–800 ng/mL.Results and discussion: Three batches of precision accuracy, selectivity, matrix effects, extraction recovery, and stability were also verified and met the requirements. The results showed that the method was reliable and successfully applied to the pharmacokinetics study of riluzole in Chinese amyotrophic lateral sclerosis patients. Meanwhile, in comparison with other prior published methods, our method has the advantages of simple sample preparation, relatively short running time, and small plasma sample consumption, which represented a high-throughput sample determination potential.
Physiological and transcriptomic analysis reveal the crucial factors in heat stress response of red raspberry ‘Polka’ seedlings
Authors: Guo Juanjuan , Zhang Ruiyu , Cheng Siqi , Fu Ziqian , Jia Peng , Luan Haoan , Zhang Xuemei , Qi Guohui , Guo Suping 
Published: August 2023

With global climate warming, recurring extreme heat and high temperatures irreversibly damage plants. Raspberries, known for their nutritional and medicinal value, are in high demand worldwide. Thus, it is important to study how high-temperature stress (HTS) affects raspberries. The physiological and biochemical responses and molecular genetic mechanisms of raspberry leaves to different HTS treatments were investigated: mild high temperature at 35°C (HT35), severe high temperature at 40°C (HT40), and the control at room temperature of 25°C (CK). The physiological results suggested that leaves in both the 35°C and 40°C treatments showed maximum relative conductivity at 4 d of stress, increasing by 28.54% and 43.36%, respectively, compared to CK. Throughout the stress period (0–4 d), malondialdehyde (MDA) and soluble protein contents of raspberry leaves increased under HT35 and HT40 treatments, while soluble sugar content first decreased and then increased. Catalase (CAT) activity increased, superoxide dismutase (SOD) activity first increased and then decreased, and peroxidase (POD) activity gradually decreased. Photosynthetic and fluorescence responses of raspberry leaves showed the most severe impairment after 4 d of stress. Transcriptomics results revealed significant alterations in 42 HSP family genes, two SOD-related differentially expressed genes (DEGs), 25 POD-related DEGs, three CAT-related DEGs, and 38 photosynthesis-related DEGs under HTS. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that these DEGs were mainly enriched in photosynthesis-antenna proteins, pentose and glucuronide interconversion, phenylpropane biosynthesis, and indole alkaloid biosynthesis. HTS induced excessive ROS accumulation in raspberry leaves, causing oxidative damage in plant cells and subsequently reducing photosynthesis in raspberry leaves. This reduction in photosynthesis, in turn, affects photosynthetic carbon fixation and starch and sucrose metabolism, which, combined with phenol propane biosynthesis, mitigates the HTS-induced damage.
A prospective study on body image disturbances during pregnancy and postpartum: the role of cognitive reappraisal
Authors: Spinoni Marta , Singh Solorzano Claudio , Grano Caterina 
Published: August 2023

BackgroundDuring pregnancy, body size rapidly modifies over a relatively short period. Literature emphasizes the need to identify the factors that influence body image during peripartum as the extent of women’s adaptation to these changes has significant repercussions on both mother’s and newborn’s health. Emotion regulation strategies (i.e., expressive suppression and cognitive reappraisal) were linked to body image in the general and clinical population, but no studies were conducted in the peripartum. The present study aims to investigate the longitudinal impact of prepartum body image disturbances on postpartum body image disturbances and to evaluate the mediational role of emotional regulation strategies.MethodsA total of 133 pregnant women completed a three-phase longitudinal study. Women answered online questionnaires during the second (T1) and the third (T2) trimesters of pregnancy, and at about 6 months postpartum (T3).ResultsFindings indicated that body image disturbances at T1 were a significant predictor of body image disturbances in the postpartum (1 year after the first assessment). Moreover, cognitive reappraisal measured at T2 partially mediated this relationship: body image disturbances in the second trimester of pregnancy were linked to less use of cognitive reappraisal in the third trimester of pregnancy, and this, in turn, was associated with worse body image disturbances at 6 months after birth.ConclusionFindings of this longitudinal study highlight the importance of assessing body image disturbances during pregnancy to early identify women at risk, and suggest cognitive reappraisal as a possible target intervention.
Autism Spectrum Disorders in forensic psychiatric investigations–patterns of comorbidity and criminality
Authors: Hofvander Björn , Nilsson Thomas , Ståhlberg Ola , Claesdotter Emma , Moberg Patricia , Ahlbäck Klara , Hildebrand Karlén Malin 
Published: August 2023

BackgroundThere are contradictory research findings regarding whether individuals with Autism Spectrum Disorders (ASDs) are more or less likely to commit crimes. The aims of the current study were to: (1) Describe psychiatric and crime-related characteristics of a large group of offenders with ASD who had undergone a Forensic Psychiatric Investigation (FPI). (2) Identify clinical subgroups among this group of offenders. (3) Investigate associations between the identified clinical subgroups and (a) psychiatric comorbidity (b) types of crimes and (c) criminal responsibility.MethodsThe study cohort consists of all subjects (n = 831) who received an ASD-diagnosis at an FPI between 2002 and 2018 in Sweden. Descriptive and clinical, as well as crime related variables were obtained from the FPIs. Non-parametric (Pearson χ2, Fisher's exact and Mann-Whitney U-test) inferential statistics were used for analyses of between-group differences and effect sizes were reported. A Latent Class Analysis was used to identify homogeneous subgroups (or classes) from categorical characteristics.ResultsThe cohort consisted of 708 men and 123 women, aged 18 to 74 yrs. Two-thirds (66.7%) of the cohort had at least one other psychiatric diagnosis, the most prevalent was substance use disorder (SUD). A severe mental disorder, equivalent to lack of criminal responsibility, was most often reported among offenders with a comorbid diagnosis of schizophrenia spectrum disorder. The most common type of crime was violent crime. Three person-oriented clinical subgroups were identified; (1) ASD with few other diagnoses; (2) ASD and very high levels of SUDs, plus moderate levels of other externalizing disorders and psychotic psychopathology and (3) ASD and moderate to high levels of personality disorders (other than ASPD) and SUDs.ConclusionOur results highlight the importance of all parts of the CJS to be prepared to handle offenders with ASD, often with high levels of additional psychiatric problems. Traditional approaches in treatment or other psychosocial interventions for ASD may need to be adapted to at least three general clinical profiles– one with mainly neurodevelopmental problems, one with a spectrum of externalizing problems and one with complex personality related difficulties.
How is caring for grandchildren associated with grandparents’ health: the mediating effect of internet use
Authors: Wang Jie , Gu Rongxing , Zhang Lanxi , Zhang Li 
Published: August 2023

ObjectivePrior studies showed mixed results of the association between grandchild care and grandparents’ health. This research focused on the mechanisms behind the above link by studying how internet use served as a mediator through which grandchild care has impacted grandparents’ health. The study aimed to draw implications to improve health of grandparents who offer care to grandchildren.MethodsUsing a sample of 16,829 grandparents aged 50 through 80 from the 2018 wave of China Health and Retirement Longitudinal Study (CHARLS), the study relied on the KHB method to conduct the analysis. Grandparental health was measured by self-rated health (SRH), instrumental activity of daily living (IADL), life satisfaction and depression.ResultsOverall, grandchild care had a positive effect on grandparental health. Those who engaged in grandchild care were more likely to use internet. In addition, internet use mediated the ways in which grandchild care impacted grandparents’ health. Interne use generally promoted the positive influence of grandparental caregiving on grandparents’ health. Specifically, the mediating effects of watching videos and chatting through the internet were most pronounced among urban grandmothers. The mediating effects of watching news were most noticeable among both urban grandmothers and grandfathers.ConclusionInternet use served as a mediator in the association between grandchild child care and grandparental health. Promoting internet usage may be an effective way reducing the negative impact of grandchild care on grandparents’ mental health. It could also increase the positive effect of caregiving on grandparents’ SRH and functional independence. The study also underscored the importance of taking rural–urban context and gender role into consideration when studying intergenerational caregiving and Chinese grandparents’ health.
The impact of disability-related deprivation on employment opportunity at the neighborhood level: does family socioeconomic status matter?
Authors: Qiu Ning , Jiang Yuxiao , Sun Zongyao , Du Mengbing 
Published: August 2023

IntroductionDifficulties in attaining employment significantly contribute to socioeconomic poverty among individuals with disabilities. However, our understanding of how socioeconomic deprivation experienced by individuals and families with disabilities influences employment opportunities remains incomplete. This study aims to explore the relationship between index of disability-related multiple deprivation (IDMD) and employment opportunities (EMPO), while also investigating the role of family socioeconomic status (FSES) in shaping this relation.MethodsThis study explores the heterogeneous effects of IDMD, FSES, and the interaction between IDMD*FSES on EMPO among four disabled population groups categorized by IDMD and FSES.ResultsResults reveal that IDMD has a significant negative impact on EMPO, suggesting that persons with disabilities are confronted with a poverty trap resulting from the relationship between IDMD and EMPO. Furthermore, FSES demonstrates an effective moderating role in the IDMD-EMPO relationship, with the greatest impact observed among disabled population groups characterized by high IDMD and low FSES.DiscussionThe findings suggest that family-level support is crucial for vulnerable groups of disabled individuals to overcome the poverty trap, surpassing the reliance on individual-level assistance alone. This study supports a paradigm shift in comprehending disability-related deprivation by acknowledging its association with families, thereby presenting opportunities to enhance the welfare of people with disabilities.
Comparative Pollen Morphology of Selected Species of Blumea DC. and Cyathocline Cass. and Its Taxonomic Significance
Authors: Peng Yulan , Pu Xuemei , Yu Qi , Zhou Hailing , Huang Tianfang , Xu Bo , Gao Xinfen 
Published: August 2023

The pollen morphology of 20 species from Blumea and Cyathocline Cass. was investigated using a light microscope (LM) and scanning electron microscopy (SEM) to explore their taxonomic significance. This study showed that pollen grains of these species were usually tricolporate, rarely tetracolporate (B. sinuata). Nine pollen types were distinguishable through the exine sculpture characters and the number of apertures. It was easily distinguished Cyathocline from species of Blumea s. str. by its much smaller size (15.04 μm × 15.07 μm) and sparse and longer spines (24 spines, spine length 4.23 μm) with acute apex, which suggest that C. purpurea might not belong to the genus Blumea s. str. The palynological characteristics indicated that Section Macrophllae and Section Paniculatae of Blumea were not monophyletic groups. The pollen morphology differentiation of B. lacera clade is consistent with the interspecific relationship revealed by the molecular phylogenetic tree. However, the pollen morphology of the Blumea densiflora clade is inconsistent with the interspecific relationship based on molecular phylogenetic analysis. This palynology research can only partly support the previously published molecular phylogeny of Blumea s. str.
Guideline for improving spatial resolution in direct-modulation Brillouin optical correlation-domain reflectometry
Authors: Ochi Seiga , Ozaki Kouta , Noda Kohei , Lee Heeyoung , Nakamura Kentaro , Mizuno Yosuke 
Published: August 2023

Abstract
We investigate the spatial resolution of direct-modulation Brillouin optical correlation-domain reflectometry (BOCDR) by exploring the impact of modulation amplitude and frequency. Our findings reveal that optimal resolution improvement is attained through an initial increase in modulation amplitude, followed by modulation frequency adjustment. These insights provide a basic guideline for enhancing the spatial resolution in direct-modulation BOCDR.
POLA ASUH ORANG TUA DALAM MEWUJUDKAN PENDIDIKAN AGAMA ISLAM PADA ANAK USIA PRA BALIGH DI DESA LARINGGI KECEMATAN MARIORIAWA KABUPATEN SOPPENG SULAWESI SELATAN
Authors: Trisnawaty Trisnawaty 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pola asuh orang tua dalam mewujudkan pendidikan agama Islam pada anak usia pra baligh di Desa Desa Laringgi Kecamatan Marioriawa Kabupaten Soppeng. Penelitian ini menggunakan pendekatan kualitatif dan metode fenomenalogi dengan melakukan proses pencarian gambaran data dari konteks kejadian secara langsung. Hasil penelitian menunjukkan pola asuh orang tua dalam mewujudkan pendidikan agama Islam pada anak usia pra baligh di Desa Laringgi Kecamatan Marioriawa Kabupaten Soppeng adalah pola asuh musyawarah dan pola asuh orang tua penelantar.
The Implication of Judges’s Decision by Reason of Li’an in Mamuju Religious Court
Authors: Setiawan Andri , Khairuddin Khairuddin , L Sudirman , Fikri  
Published: August 2023

Penelitian ini menjelaskan tentang Putusan Hakim karena li’an di Pengadilan Agama Mamuju. Penelitian ini dilakukan untuk mengetahui bagaimana proses penyelesaian perkara li’an yang diproses di Pengadilan Agama Mamuju serta bagaimana dampak dari Implikasi putusan Hakim Karena li’an. Penelitian ini adalah penelitian lapangan (fleld research) dengan menggunakan metode kualitatif deskriptif. Fokus penelitian ini adalah Implikasi Putusan Hakim karena li’an di Pengadilan Agama Mamuju. Adapun sumber data dalam penelitian ini ialah sumber data primer dan skunder dengan tehnik okservasi, interview dan dokumentasi. Hasil penelitian ini menunjukkan bahwa: implikasi cerai gugat karena li’an di Pengadilan Agama Mamuju yang diputus oleh hakim Pengadilan Agama Mamuju tentunya memiliki dua factor yaitu berdampak pada kebaikan dari kedua belah pihak suami isteri. Dengan ketentuan bahwa jika dipisahkan kemungkinan kedua suami isteri masing-masing mendapatkan pasangan yang lebih baik. Dampak kedua terkait pada permasalahan anak dan keluarga. Proses penyelesaian perkara cerai gugat karena li’an oleh hakim di Pengadilan Agama Mamuju ialah mengunakan mode seni hakim dengan cara melihat sebab adanya li’an itu sendiri. jadi secara metode yang dijelaskan dalam Al-Qur’an itu tidak diterapkan pada Pengadilan Agama Mamuju dikarenakan itu sangat berap bagi pelaku li’an. Akibat Hukum dan Status Terhadap Anak Li’an Kedudukan hukum anak akibat perceraian li’an serta perlindungan hak anak pasca perceraian li’an ditinjau dari segi hukum perdata. Kedudukan anak yang dalam keluarga yang dilahirkan akibat dari li’an mempunyai status hukum yang sama dengan anak zina.