bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of analytical method for determination of amlodipine and benazepril in bulk and pharmaceutical dosage form by RP-HPLC
Authors: Rayudu Hari Krishna  , T.K.V. Kesav Rao  , Ch. Prasad  
Published: September 2023

A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Amlodipine and Benazepril, in its pure form as well as in capsule dosage form. Chromatography was carried out on an Altima C18 (4.6 x 150 mm, 5µm) column using a mixture of Methanol: TEA Buffer pH 4.5: Acetonitrile (50:25:25) as the mobile phase at a flow rate of 1.0 mL/min, the detection was carried out at 225 nm. The retention time of the Amlodipine and Benazepril was 2.102, 3.537 ±0.02 min respectively. The method produce linear responses in the concentration range of 5-25 mg/ml of Amlodipine and 20-100 mg/ml of Benazepril. The method precision for the determination of assay was below 2.0 %RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.
Preparation and evaluation of press coated floating pulsatile drug delivery system of telmisartan
Authors: Saka Abisheknath  , A. Venkateswara Rao  , M. Vineela  
Published: September 2023

The aim of present investigation was to develop press coated tablets for Floating pulsatile drug delivery of Telmisartan used for is a medication used for high blood pressure, heart failure, and diabetic kidney disease. The drug delivery system was designed to deliver the drug such a time when it could be needful of patient conditions. The press coated tablets containing Telmisartan in the inner core were formulated by direct compression method with an outer coating of different amount of Chitosan. The release profile of press coated tablet exhibited a lag time. The optimized batch F9 gave good drug release of 99.58 %
Evaluasi Keandalan Sistem Distribusi 20 Kv Pada Penyulang J4 J5 J6 Di PT. PLN (Persero) Area Balikpapan Menggunakan Nilai SAIDI dan SAIFI
Authors: Nainggolan Onglan , Bustani  , Arbain  
Published: September 2023

Indeks keandalan sistem distribusi merupakan merupakan nilai mutu sistem untuk menyalurkan energi listrik ke pelanggan secara kontinu dalam periode waktu tertentu dan dalam kondisi tertentu. Nilai indeks keandalan sistem distribusi yang digunakan oleh PLN adalah standar SPLN No. 59 Tahun 1985 dan standar SPLN 68-2:1986 yaitu nilai SAIDI (System Average Interruption Duration Index) sebesar 21 jam/pelanggan/tahun dan nilai SAIFI (System Average Interruption Frequency Index) sebesar 3,2 kali/pelanggan/tahun. Penelitian ini bertujuan untuk mengevaluasi tingkat keandalan sistem distribusi tenaga listrik di PT. PLN (Persero) Area Balikpapan terutama pada penyulang J4 J5 J6 dengan menghitung nilai SAIDI dan SAIFI selama periode waktu 1 tahun. Data gangguan yang ditinjau adalah data gangguan yang terjadi selama tahun 2018. Dari hasil perhitungan diperoleh bahwa pada penyulang J4 nilai SAIDI sebesar 21,94 jam/ pelanggan/tahun dan nilai SAIFI sebesar 3.26 kali/ pelanggan/tahun. Pada penyulang J5 nilai SAIDI sebesar 30,09 jam/ pelanggan/ tahun dan nilai SAIFI sebesar 3,99 kali/pelanggan/tahun. Pada penyulang J6 nilai SAIDI sebesar 50,96 jam/pelanggan/ tahun dan nilai SAIFI sebesar 5,24 kali pelanggan/tahun. Dibandingkan terhadap nilai standar SPLN No. 59 Tahun 1985 dan standar SPLN 68-2: 1986 maka nilai indeks keandalan penyulang J4 J5 J6 masih di bawah standar atau dikategorikan sebagai kurang handal.
Estimation of Missing Value in Sudoku Square Design
Authors: Shehu A.  , Dauran, N. S.  , Usman, A. G.  
Published: September 2023

Missing values or missing data occur in experiments as a result of several reasons, these reasons could be natural or it happened due to failure on the part of experimenter. When missing value occurred it causes biasness to the analysis and failure in the efficiency. The study considered the Sudoku square design of order where row-blocks and column-blocks are equal, rows and columns are equal with one missing value. The missing value is estimated by comparing the missing value in respect to Latin square of order and also in respect to randomized block design, the estimator for the missing value is derived and numerical illustration is given to show how the estimator is used to obtain the estimate of a missing value when and in a squared Sudoku design.
Influence of Organic Manures and Organic Sprays on Productivity and Economics of Summer Greengram [Vigna radiata (L.) Wilczek]
Authors: Bhargavi K. , Sumathi V. , Reddy G. Krishna , Umamahesh V. 
Published: September 2023

A field experiment was conducted to investigate the influence of organic fertilizers and organic sprays on the productivity and economic parameters of summer greengram (Vigna radiata) cultivation. The experiment was designed as a split-plot design with three replications. The primary plots encompassed four organic fertilizer treatments: Control (M1), Farm yard manure (M2), Vermicompost (M3), and Poultry manure (M4). The sub-plots included three organic spray treatments: Control (S1), Panchagavya (S2), and Jeevamrutha (S3).
The results of the experiment revealed that the combination of poultry manure as the organic fertilizer in conjunction with the application of Panchagavya spray had the most significant impact on both seed yield (779 kg ha-1) and haulm yield (1909 kg ha-1) for summer greengram cultivation. Furthermore, this specific combination demonstrated notably higher gross returns (₹48,648 ha-1), net returns (₹30,125 ha-1), and a favourable B C ratio of 2.60.
Breeding Value of Quality Protein Maize Inbreds
Authors: Hemavathy A. Thanga , Kavitha S. , Duraisamy Kavithamani , Sakila M. , Geetha V. Vijaya , Dhanushkodi V. 
Published: September 2023

The cultivar with high and positive breeding value can be used as a good parent for breeding of traits in hybridization programs because they can better transfer the desirable characteristics to the progeny in each case. To obtain the breeding value present investigation was carried out in maize with 33 inbreds of maize and seven inbreds of QPM lines to assess the breeding value of maize progenies for the better selection. The progeny values ranged from 62.04 (UMI 48 x CO 1) to 126.26 (CML 145 x CO 1). The breeding value ranged from 0.17 (UMI 48 x CO 1) to 0.39 (CML 145 x CO 1). CML 145 x CO 1 had high breeding value (0.39) with high progeny mean. UMI 48 x CO 1 had low breeding value (-0.17) with low progeny mean (90.80). The parent CML 145 was the superior most both for perse mean (P38=126.26) as well as for its hybrid progeny mean (C2= 168).
An Estimate of Certain Chelated, Non-Chelated Zinc Sources and Levels on Zinc Use Efficiency, Availability and Yield of Rice Grown in Texturally Different Soils
Authors: Sriramachandrasekharan M. V.  , Muthukumararaja T. , Senthilvalavan P. 
Published: September 2023

This study was planned to estimate the performance of three zinc fertilizers [Zn sulfate heptahydrate (non-chelated), Zn- EDTA and Zn-humate (chelated)] at four levels (0, 2.5, 5.0, and 7.5 mg kg-1) on zinc use efficiency, availability and crop productivity with rice. Field trials were conducted in clay loam and sandy clay loam textured soils using factorial randomized block design (FRBD) with three replications. Data recorded on yield, Zn uptake, DTPA-Zn, Zn uptake efficiency (ZnUPE), Zn utilization efficiency (ZnUTE), Zn use efficiency (ZnUE), fertilizer Zn uptake efficiency (FZnUPE), fertilizer Zn utilization efficiency (FZnUTE) and fertilizer Zn use efficiency (FZnUE). Among sources, Zn- EDTA recorded the highest grain (5307, 5545 kg ha-1) and straw (6691, 6913 kg ha-1) yield, Zn uptake and DTPA-Zn in both soils, respectively. Among Zn levels, invariably of zinc sources the highest grain (5556, 5771 kg ha-1) and straw (7029, 7120 kg ha-1) yield obtained with 5 mg kg-1 Zn, while 7.5 mg kg-1 Zn registered the highest zinc uptake and DTPA- Zn both in clay loam and sandy clay loam soil, respectively. Our results identified that increased Zn levels increased ZnUPE, ZnUTE, and ZnUE. Addition of 2.5 mg kg-1 Zn recorded the highest FZnUPE and FZnUE, while 5.0 mg kg-1 Zn recorded the highest FZnUTE invariably of soil textures. Amongst the sources, Zn humate recorded higher ZnUE and its components. The study concluded that chelated zinc sources performed well than non-chelated (Zn sulphate heptahydrate), and Zn EDTA was more effective than Zn humate in both experimental soils.
Risk of Multiple Primary Cancers in Patients With Merkel Cell Carcinoma
Authors: Eid Edward , Maloney Nolan J. , Cai Zhuo Ran , Zaba Lisa C. , Kibbi Nour , John Esther M. , Linos Eleni 
Published: September 2023

ImportanceThe risk of subsequent primary cancers after a diagnosis of cutaneous Merkel cell carcinoma (MCC) is not well established.ObjectiveTo evaluate the risk of subsequent primary cancers after the diagnosis of a first primary cutaneous MCC.Design, Setting, and ParticipantsThis cohort study analyzed data from 17 registries of the Surveillance, Epidemiology, and End Results (SEER) Program from January 1, 2000, to December 31, 2019. In all, 6146 patients diagnosed with a first primary cutaneous MCC were identified.Main Outcomes and MeasuresThe primary outcome was the relative and absolute risks of subsequent primary cancers after the diagnosis of a first primary MCC, which were calculated using the standardized incidence ratio (SIR; ratio of observed to expected cases of subsequent cancer) and the excess risk (difference between observed and expected cases of subsequent cancer divided by the person-years at risk), respectively. Data were analyzed between January 1, 2000, and December 31, 2019.ResultsOf 6146 patients with a first primary MCC diagnosed at a median (IQR) age of 76 (66-83) years, 3713 (60.4%) were men, and the predominant race and ethnicity was non-Hispanic White (5491 individuals [89.3%]). Of these patients, 725 (11.8%) developed subsequent primary cancers, with an SIR of 1.28 (95% CI, 1.19-1.38) and excess risk of 57.25 per 10 000 person-years. For solid tumors after MCC, risk was elevated for cutaneous melanoma (SIR, 2.36 [95% CI, 1.85-2.97]; excess risk, 15.27 per 10 000 person-years) and papillary thyroid carcinoma (SIR, 5.26 [95% CI, 3.25-8.04]; excess risk, 6.16 per 10 000 person-years). For hematologic cancers after MCC, risk was increased for non-Hodgkin lymphoma (SIR, 2.62 [95% CI, 2.04-3.32]; excess risk, 15.48 per 10 000 person-years).Conclusions and RelevanceThis cohort study found that patients with MCC had an increased risk of subsequently developing solid and hematologic cancers. This increased risk may be associated with increased surveillance, treatment-related factors, or shared etiologies of the other cancers with MCC. Further studies exploring possible common etiological factors shared between MCC and other primary cancers are warranted.
Assessing the truthfulness of security and defence news in Central and Eastern Europe: The role of cognitive style and the promise of epistemic sophistication
Authors: Mustață Marinel‐Adi , Răpan Ivona , Dumitrescu Lucian , Dobreva Hristina , Dimov Petko , Lis Andrzej , Révayová Eva , Marineanu Vasile , Buluc Ruxandra , Olariu Cosmin , Lucinescu Alexandru , Buță Cosmin 
Published: September 2023

AbstractIn this study, we sought to determine whether findings associating cognitive style with news evaluation can be generalized within a Central and Eastern European (CEE) context. We examined the relevance of actively open‐minded thinking, need for cognition, analyticity, and dogmatism in determining the truthfulness of security and defence news headlines. Drawing from a sample of 500 participants from Bulgaria, Poland, Romania, and Slovakia, our results align closely with effect sizes documented in mainstream literature concerning belief in fake news (BFN). In contrast, none of the tested cognitive style measures predicted belief in real news (BRN), and the cognitive reflection test yielded no usable results. The study also explored the utility of a new measure: epistemic sophistication. Our findings were moderately promising for the multiplicism subscale in predicting both BFN and BRN.
I will keep your memory! Reasons for remembering lost loved ones
Authors: Pociunaite Justina , Wolf Tabea 
Published: September 2023

AbstractRemembering the lost loved one is an integral part of bereavement process. While we know from prior research that memories in general are used for specific reasons (e.g., for identity processes or within social relationships), it is unclear for what reasons people remember their lost loved ones. Based on previous literature, we assumed that memory emotionality and bereavement reaction are associated with why people reminisce about their lost loved ones. In total, 100 adults reported up to 10 of their most important memories about a lost loved one and rated them regarding emotional valence, intensity and different types of memory use. Participants also rated their feelings of grief and personal growth post‐loss. Findings demonstrate that memories about lost loved ones are used in ways considered adaptive and maladaptive. Importantly, the reasons for remembering lost loved ones are strongly associated with emotional qualities of memories and the individual bereavement reaction.
Designing Reflective Hybrid Counter Electrode for Fiber Dye‐Sensitized Solar Cell with Record Efficiency
Authors: Zhu Zhengfeng , Lin Zhengmeng , Gu Yu , Song Jiatian , Kang Xinyue , Jiang Hongyu , Peng Huisheng 
Published: September 2023

AbstractFiber solar cells can be woven into textiles to effectively supply electricity for wearables and have attracted increasing interests in the past decade. However, achieving high power conversion efficiencies in real‐world applications remains a significant challenge for power supply textiles. Here a unique hybrid counter electrode made from metal current collector fiber with high electrical conductivity, aligned carbon nanotube sheet with high electrocatalytic property, and porous titanium dioxide/poly(vinylidene fluoride‐co‐hexafluoropropylene) film with high light reflectance is designed. For the resulting fiber dye‐sensitized solar cell, a rapid charge collection and transport are achieved, and the unique advantage of absorbing light from all directions is effectively realized, producing a record power conversion efficiency of 12.52%. The power conversion efficiency varies below 10% after bending, twisting, or pressing for 1000 cycles. These fiber dye‐sensitized solar cells are further integrated with fiber batteries as power systems for a smart bracelet, demonstrating the effective power solution for wearables.
Localized Exciton Anatomy and BandGap Energy Modulation in 1D MoS2 Nanostructures
Authors: van der Lippe Stijn , Brokkelkamp Abel , Rojo Juan , Conesa‐Boj Sonia 
Published: September 2023

This study presents an in‐depth investigation of the electronic properties and bandgap energy distribution in 1D molybdenum disulfide (1D‐MoS2) nanostructures. Through a combination of high‐angle annular dark‐field scanning transmission electron microscopy (HAADF‐STEM) and electron energy‐loss spectroscopy (EELS), it reveals significant differences between 1D‐MoS2 nanostructures and their 2D counterparts, shedding light on their localized exciton behavior and their bandgap energy modulation within the nanostructures. Excitonic peaks at around 2 and 3 eV appear localized at the ends or along the sides of the 1D‐MoS2 nanostructures, while the plasmonic resonance at 8.3 eV retains its inner‐region localization. It demonstrates the spatial dependence of the bandgap energy, with the central region exhibiting a bandgap of approximately 1.2 eV, consistent with bulk MoS2, while regions characterized by curvature‐induced local strain fields exhibit instead a noticeable reduction. The findings provide valuable insights into the intricate relationship between excitonic behavior and bandgap sensitivity in 1D‐MoS2 nanostructures, streamlining the design and optimization of nanophotonic and optoelectronic devices.
Flexible and Transformable Ceramic Aerogels via a Fire‐Reborn Strategy for Thermal Superinsulation in Extreme Conditions
Authors: Cheng Yingying , Ma Bingjie , Hu Peiying , Zhang Junxiong , Hu Dongmei , Wang Jin 
Published: September 2023

AbstractEffective thermal superinsulation in extremely high temperatures (EHT) is crucial for aerospace, industrial, and civilization activities. However, current strategies relying on ceramic materials face limitations due to their high thermal conductivity and brittleness in specific conditions. In this study, a feasible and scalable method for synthesizing a flexible, lightweight, and transformable fire‐reborn silica‐alumina hybrid ceramic aerogel (FR‐SACA) is presented, which is achieved by rearranging silica aerogel microparticles and Al2O3 ceramic fibers using a self‐sacrifice polymer, resulting in a bio‐inspired bird nest structured FR‐SACA. The SACA exhibits exceptional properties, including an ultra‐low density of 0.01 g cm−3, a low thermal conductivity of 0.029 W m−1 K−1, and a reversible compression of up to 80%. Notably, a 20 mm‐thick FR‐SACA demonstrates a remarkable temperature reduction of 1179.6 °C when exposed directly to a 1300 °C flame, suggesting its potential as a thermal superinsulation material in EHT environments. Furthermore, the transformability of SACA enables in situ fabrication on surfaces with diverse heteromorphic structures, such as flat, bent, and angled shapes, thereby providing thermal superinsulation for various constructions. The Phoenix Nirvana process opens up new possibilities for synthesizing ceramic aerogels with desirable flexibility and adaptive properties, facilitating effective thermal management under extreme conditions.
Biotoxicity of Halide Perovskites in Mice
Authors: Li Guixiang , Liu Yong‐Tao , Yang Feng , Li Meng , Zhang Zuhong , Pascual Jorge , Wang Zhao‐Kui , Wei Shi‐Zhe , Zhao Xin‐Yuan , Liu Hai‐Rui , Zhao Jin‐Bo , Lin Chieh‐Ting , Li Jun‐Ming , Li Zhe , Abate Antonio , Cantone Irene 
Published: September 2023

AbstractHalide perovskites are crystalline semiconductors with exceptional optoelectronic properties, rapidly developing toward large‐scale applications. Lead (II) (Pb2+) is the core element used to prepare halide perovskites. Pb2+ can displace key 2+ elements, including calcium, zinc and iron, that regulate vital physiological functions. Sn2+ can replace Pb2+ within the perovskite structure and, if accidentally dispersed in the environment, it readily oxidizes to Sn4+, which is compatible with physiological functions and thus potentially safe. The 3+ salt bismuth (III) (Bi3+) is also potentially safe for the same reason and useful to prepare double perovskites. Here, this work studies the biotoxicity of Pb, Sn, and Bi perovskites in mice for the first time. This work analyses histopathology and growth of mice directly exposed to perovskites and investigate the development of their offspring generation. This study provides the screening of organs and key physiological functions targeted by perovskite exposure to design specific studies in mammalians.
Exosomes Derived from M2 Microglial Cells Modulated by 1070‐nm Light Improve Cognition in an Alzheimer's Disease Mouse Model
Authors: Chen Chengwei , Bao Yuting , Xing Lu , Jiang Chengyong , Guo Yu , Tong Shuangmei , Zhang Jiayi , Chen Liang , Mao Ying 
Published: September 2023

AbstractNear‐infrared photobiomodulation has been identified as a potential strategy for Alzheimer's disease (AD). However, the mechanisms underlying this therapeutic effect remain poorly characterize. Herein, it is illustrate that 1070‐nm light induces the morphological alteration of microglia from an M1 to M2 phenotype that secretes exosomes, which alleviates the β‐amyloid burden to improve cognitive function by ameliorating neuroinflammation and promoting neuronal dendritic spine plasticity. The results show that 4 J cm−21070‐nm light at a 10‐Hz frequency prompts microglia with an M1 inflammatory type to switch to an M2 anti‐inflammatory type. This induces secretion of M2 microglial‐derived exosomes containing miR‐7670‐3p, which targets activating transcription factor 6 (ATF6) during endoplasmic reticulum (ER) stress. Moreover, it is found that miR‐7670‐3p reduces ATF6 expression to further ameliorate ER stress, thus attenuating the inflammatory response and protecting dendritic spine integrity of neurons in the cortex and hippocampus of 5xFAD mice, ultimately leading to improvements in cognitive function. This study highlights the critical role of exosomes derive from 1070‐nm light‐modulated microglia in treating AD mice, which may provide a theoretical basis for the treatment of AD with the use of near‐infrared photobiomodulation.
Innovative Real‐Time Flow Sensor Using Detergent‐Free Complex Emulsions with Dual‐Emissive Semi‐Perfluoroalkyl Substituted Α‐Cyanostilbene
Authors: Rakesh Narani , Tu Hsiung‐Lin , Chang Po‐Chun , Gebreyesus Sofani Tafesse , Lin Che‐Jen 
Published: September 2023

AbstractIn this study, the potential of complex emulsions is investigated as transducers in sensing applications. Complex emulsions are stabilized without external detergents by developing a novel α‐cyanostilbene substituted with PEG and semi‐perfluoroalkyl chain (CNFCPEG). CNFCPEG exhibits unique variable emission properties depending on its aggregation state, allowing dual blue and green emissions in complex emulsions with hydrocarbon‐in‐fluorocarbon‐in‐water (H/F/W) morphology. The green excimer emissions result from the self‐assembly of CNFCPEG at the fluorocarbon/water interface, while the blue emission observed is due to aggregation in the organic phase. A novel flow‐injection method is developed by incorporating complex emulsions with CNFCPEG into multiple‐well flow chips (MWFC). Iodine is successfully detected in a mobile aqueous solution by monitoring morphology changes. The findings demonstrate that self‐stabilized complex emulsions with MWFC hold great promise for real‐time sensing without costly instruments.
Health effects of filtering facepiece respirators: Research and clinical implications of comfort, thermal, skin, psychologic, and workplace effects
Authors: Harber Philip , Beckett William S. 
Published: September 2023

AbstractFiltering facepiece respirators (FFR's) such as N95s have become widely used in appropriate settings for personal respiratory protection and are increasingly used beyond workplace settings. Concerns about possible adverse effects have appeared in many publications, particularly since the COVID‐19 pandemic led to much more widespread use. This paper synthesizes known effects based upon review of publications in PubMed since 1995, addressing effects other than pulmonary and cardiovascular (reviewed elsewhere). Findings: (1) Subjective discomfort is very frequently reported; this includes general discomfort or organ‐system‐specific complaints such as respiratory, headache, dermatologic, and heat. Research methods are widely divergent, and we propose a taxonomy to classify such studies by methodology, study population (subjects, experimental vs. observational methodology, comparator, specificity, and timeframe) to facilitate synthesis. (2) Objective measures of increased heat and humidity within the mask are well documented. (3) Frequency and characteristics of dermatologic effects have been insufficiently evaluated. (4) Physical mask designs are varied, making generalizations challenging. (5) More studies of impact on work performance and communication are needed. (6) Studies of effect of FFR design and accompanying training materials on ease and consistency of use are needed.