bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily aspirin reduced the incidence of hepatocellular carcinoma and overall mortality in patients with cirrhosis
Authors: Lee Chern-Horng , Hsu Chiu-Yi , Yen Tzung-Hai , Wu Tsung-Han , Yu Ming-Chin , Hsieh Sen-Yung 
Published: January 2023

Abstract
Background/purpose
Cirrhosis is the primary risk factor for hepatocellular carcinoma (HCC) and gastrointestinal bleeding (GI). We aimed to assess the efficacy and safety of daily aspirin on HCC occurrence, overall survival, and GI bleeding in cirrhotic patients.
Methods
35898 eligible cases were enrolled for analyses from an initial 40603 cirrhotic patients without tumor history. Patients continuously treated with aspirin for at least 84 days were in the therapy group, whereas those without treatment were controls. A 1:2 propensity score matching by age, sex, comorbidities, drugs, and significant clinical laboratory tests with covariate assessment was used.
Results
Multivariate regression analyses revealed that daily aspirin use was independently associated with a reduced risk of HCC (three-year HR 0.567; 95% CI 0.371–0.869; P = 0.0091; five-year HR 0.629, 95% CI 0.449–0.882; P = 0.0072) inversely correlated with the treatment duration [3–12 months: HR 0·88 (95% CI 0.576–1.344); 12–36 months: HR 0.56 (0.311–0.996); and ≥ 36 months: HR 0.37 (0.178–0.764)]. Overall mortality rates were significantly lower among aspirin users compared with untreated controls [three-year HR 0.43 (0.33–0.57); five-year HR 0.51 (0.42–0.63)]. The risk for gastrointestinal bleeding was not increased among aspirin users whether with [three-year HR 0.507 (0.360–0.712); five-year HR 0.511 (0.362–0.720)] or without previous gastrointestinal bleeding [three-year HR .664 (0.489–0.902); five-year HR 0.656 (0.500–0.860)]. Consistent results were obtained when the laboratory data were included in the propensity score for matching.
Conclusion
Long-term aspirin use significantly reduced the incidence of HCC and overall mortality without increasing gastrointestinal bleeding in cirrhotic patients.
Perception of social inclusion/exclusion and response inhibition in adolescents with past suicide attempt: a multimodal task-based fMRI study
Authors: Jollant Fabrice , Gifuni Anthony , Pereira Fabricio , Chakravarty Mallar , Lepage Martin , Chase Henry , Geoffroy Marie-Claude , Lacourse Eric , Phillips Mary , Turecki Gustavo , Renaud Johanne 
Published: January 2023

Abstract
The occurrence of suicidal behaviors increases during adolescence. Hypersensitivity to negative social signals and deficits in cognitive control are putative mechanisms of suicidal behaviors, which necessitate confirmation in youths. Multidomain functional neuroimaging could enhance the identification of patients at suicidal risk beyond standard clinical measures. Three groups of adolescents (N = 96; 78% females, age = 11.6–18.1) were included: patients with depressive disorders and previous suicide attempts (SA, n = 29); patient controls with depressive disorders but without suicide attempt (PC, n = 35); and healthy controls (HC, n = 32). We scanned participants with 3T-MRI during social inclusion/exclusion (Cyberball Game) and response inhibition (Go-NoGo) tasks. Neural activation was indexed by the blood-oxygenation-level dependent (BOLD) of the hemodynamic response during three conditions in the Cyberball Game (“Control condition”, “Social Inclusion”, and “Social Exclusion”), and two conditions in Go-NoGo task (“Go” and “NoGo” blocks). ANCOVA-style analysis identified group effects across three whole-brain contrasts: 1) NoGo vs. Go, 2) Social inclusion vs. control condition, 3) Social inclusion vs. control condition). Normalized contrasts in significant clusters were used to train a support vector machine-based classifier with a stratified 5-fold cross-validation, and diagnostic performance was assessed. In line with previous adult studies, we found that SA had lower activation in the left insula during social inclusion vs. control condition compared to PC and HC. We also found that SA compared to PC had higher activity in the right middle prefrontal gyrus during social exclusion vs. control condition, and in bilateral precentral gyri during NoGo vs. Go conditions. Task-related measures (Self-reported emotional reactivity in the Cyberball Game, response times and number of errors in the Go-NoGo Task) did not discriminate between groups. Moreover, while clinical data (Self-reported depression and impulsivity scores) yielded moderate accuracy (Accuracy: 70%/ Area Under Curve: 0.81), activity during Go-NoGo (81%/0.90), Cyberball Game (89%/0.90), or a combination (88%/0.95) significantly enhanced identification of past suicidal behaviors. In conclusion, adolescent suicidal behaviors are likely associated with neural alterations across multiple domains. Alterations in the processing of social perception and response inhibition may underlie the development of suicidal crises, from onset with social triggers to susceptibility to act out. Neuroimaging should be further tested as a tool to predict suicidal behavior.
Worst case climate simulations show that heatwaves could cause major disruptions in the Paris 2024 Olympics
Authors: Yiou Pascal , Cadiou Camille , Faranda Davide , Jézéquel Aglaé , Malhomme Nemo , Milishevich George , Noyelle Robin , Pons Flavio , Robin Yoann , Vrac Mathieu 
Published: January 2023

Abstract
The Summer Olympic Games in 2024 will take place during the apex
of the temperature seasonal cycle in the Paris Area. The midlatitudes of the Northern hemisphere have witnessed a few intense heatwaves since the 2003 event [1]. Those heatwaves have had environmental and health impacts, which often came as surprises [2]. In this paper, we search for the most extreme heatwaves in Ile-de-France that are physically plausible, under climate change scenarios, for the decades around 2024. We circumvent the sampling limitation by applying a rare event algorithm [3] on CMIP6 data [4] to evaluate the range of
such extremes. We find that the 2003 record can be exceeded by more than 4◦C in Ile-de-France before 2050, with a combination of prevailing anticyclonic conditions and cut-off lows. This study intends to build awareness on those unprecedented events, against which our societies are ill-prepared. Those results could be extended to other areas of the world.
Improved Inference for Interactive Fixed Effects Model under Cross-Sectional Dependence
Authors: Gong Zhenhao , Kim Min Seong 
Published: January 2023

Abstract

This paper proposes an inference procedure for the interactive fixed effects model that is valid in the presence of cross-sectional dependence. When the error terms are cross-sectionally dependent, the Least Square (LS) estimator of this model is asymptotically biased and therefore the associated confidence interval tends to have a large coverage error. To address this, we propose a bias correction of the LS estimator and a cross-sectional dependence robust variance estimator to construct associated test statistics. The paper also discusses practical issues in implementing the proposed method, including the construction of distance that reflects the decaying pattern of cross-sectional dependence and the selection of the bandwidth parameters. Monte Carlo simulations show our procedure works well in finite samples. As empirical illustrations, we apply our procedure to study the effect of divorce law reforms on divorce rates and the impact of clean water and sewerage interventions on child mortality.
JEL Classification: C12 , C13 , C15 , C31 , C33 , J12 , I18
Enzalutamide and EPI-001 in T47D: Blocking Androgen receptor/Androgen receptor variant7 modulates NF-ĸB/c-Myc axis, cyclins A, E, &amp; C, epithelial to mesenchymal transition markers, angiogenesis, and metastasis
Authors: Ali Belal M , Abhar Hanan El , Mohamed Ghada , Sharaky Marwa , Shouman Samia A. , Kamel Marwa 
Published: January 2023

Abstract
Androgen receptor (AR) and its splicing variant 7 (ARv7) play vital roles in the pathobiology of breast cancer (BC) but their role in the estrogen receptor-positive (ER+) type is controversial, hence, we studied the influence of the blockers of AR (Enzalutamide) and ARv7 (EPI-001) on tumorigenesis processes using T47D, an ER+ BC cell line. We showed that although both inhibitors failed to reduce cell growth and affect AR content, only Enzalutamide reduced the ARv7. Mechanistically, the drugs successfully arrested the cell cycle at S-phase and downregulated the protein expression of cyclins A, E, & C. Additionally, they inhibited the cell proliferation stimulator nuclear factor kappa B (NF-ĸB), whereas only EPI-001 reduced the cell regulatory marker c-Myc. They also opposed the endothelial-to-mesenchymal transition (EMT) process, by boosting the epithelial marker E-cadherin and reducing the protein expression of the mesenchymal marker fibronectin. Their anti-metastatic potential was evidenced by the hindrance of cell migration using the wound healing assay and further confirmed by the downregulation of metalloproteinase (MMP) 2 and 9 protein expression, and protein content of Rho kinase (ROCK)1 and 2. Besides, by downregulating the protein expression of vascular endothelial growth factor (VEGF) the drugs point to their anti-angiogenic aptitude. In conclusion, this in-vitro study is the first to prove the importance of blocking AR/ARv7 using Enzalutamide and EPI-001 in decreasing cancer cell survival, EMT, and metastasis in ER+ BC cells, findings that still need further studies to unveil the role of these inhibitors in BC.
Enhancing waste activated sludge dewaterability by strongly oxidant, KMnO4, under different pH conditions
Authors: Pan Weiliang , Li Jiaoni , Zhang Xun , Liang Shan , Kang Yinghao , Deng Rui , Gu Li , He Qiang 
Published: January 2023

Abstract
In this study, we attempted to examine the dewaterability performances of sludge after pH/KMnO4 treatment, with the goal of understanding the dewaterability of strong oxidizers to waste activated sludge.With adjustment of pH, the impacts of different KMnO4 dosing on sludge dewatering are investigated.It plays good dewatering performance after treated by pH/KMnO4,which showed by capillary suction ti-mes (CST) decreased from 263.4s to 30.1s,and SRF fell by about 19.6%.The result perfomanced that the proteins and polysaccharides were significant decreased in tightly-bound EPS.Meanwhile,it was got that higher zeta potentials, and more obvious T2 after treatment.According to the changes of sludge’s physicochemical properties,and the variety of EPS,explained the mechanisms of improv-ed sludge dewatering under pH/KMnO4 conditions. Under the strong oxidation, the structure surrounding the bound water is oxidized and the bound water is released, so the dewaterability of the sludge is improved.
Factors influencing utilization of universal Gestational Diabetes Mellitus screening services among mothers in Sri Lanka: A cross sectional study
Authors: Chandana Godevithanage Janaka , Wijesinghe Champa Jayalakshmie 
Published: January 2023

Abstract
Background: Gestational Diabetes Mellitus (GDM) is associated with adverse maternal and perinatal outcomes and increased risk of developing diabetes in later life for both child and mother. Early detection of mothers with risk of GDM is pivotal in preventing such adverse outcomes. Sri Lanka adopted universal GDM screening at two time points in pregnancy (before 12 weeks and between 24 to 28 weeks) since 2014 and its utilization has not been assessed. This study aimed to assess utilization of GDM screening services and associated factors among antenatal mothers in Southern Sri Lanka.
Methods: A cross-sectional study was carried out in a convenient sample of 420 postpartum mothers delivered at three hospitals in Matara district, Sri Lanka. Data were collected using an interviewer-administered questionnaire. A data record sheet was used to collect information on availability of screening services and the logistics to provide services. Data were analysed using SPSS software and Chi square test was used to assess the association between variables.
Results: Mean age (SD) of the mothers in the sample was 29 (5.2) and the majority were in their first or second pregnancy. The coverage of first and second screening tests were 91.4% and 94.5% and timeliness were 72.4% and 59.5%, respectively. Median period of amenorrhoea at first and second screening were 10.0 (inter-quartile range: 7.5-12.5) weeks and 28.0 (inter-quartile range: 26.5-29.5) weeks.
A higher utilization was associated with higher maternal education for both screening tests (p=0.021 and p=0.025). Primiparity (p=0.033), nulliparity (p=0.03), planned pregnancy (p=0.00), proximity of nearest laboratory (p=0.02) and having family support (p=0.025) were positively associated with having at least one screening test. Timeliness of screening was associated with performing the test at field clinics for both screening tests (p<0.001 and p=0.007). Being unemployed (p=0.005), planned pregnancy (p=0.023) and availability of logistics at field clinics (p=0.007) were associated with timely performance of at least one screening test.
Conclusions: Though a high utilization of GDM screening was observed among antenatal mothers, measures should be taken to ensure timeliness of screening through improved availability and accessibility of screening facilities. Further studies are recommended to assess service provider’s perspective.
An Acceleration-based Prediction Strategy for Dynamic Multi-objective Optimization
Authors: Zhang Junxi , Qu Shiru , Zhang Zhiteng , Cheng Shaokang , Li Mingxing , Bi Yang 
Published: January 2023

Abstract
This paper addresses the problem of dynamic multiobjective optimization problems (DMOPs), by demonstrating new approaches to change detection and change prediction in an evolutionary algorithm framework. Because the objectives of such problems change over time, the Pareto optimal set (PS) and Pareto optimal front (PF) are also dynamic. First, we propose a new change detection method which achieves greater sensitivity by considering changes in both the PS and the PF, unlike most previous approaches. Second, when changes occur, a secondorder (acceleration-based) prediction strategy is proposed to predictively re-initialize the population close to the new set of optima. We compare the performance of the proposed algorithm against two other state-of-the-art algorithms from the literature, using ten different benchmark dynamic instance test problems. Experimental results show that the proposed method outperforms the other algorithms on most of the test problems.
An Image Based 3D Modelling Framework for Li-S Batteries
Authors: Dai Xiaoyu , Kulkarni Nivedita , Robinson James , Brett Dan , Shearing Paul , Jervis Rhodri 
Published: January 2023

Abstract
Lithium Sulfur batteries the represent the next generation battery chemistry that is closest to commercialisation. Having particular advantages in gravimetric energy density, they still suffer from low-rate performance and capacity fade, linked to the complex multi-step electrochemistry and heterogenous electrode structures. Physics-based models of batteries have long been used to understand and predict their behaviour; traditionally, 1D volume-averaged continuum approaches are used, not accounting for the heterogenous structure of the electrode. For the first time, we present a three-dimensional electrochemical model of a Li-S battery based on real electrode microstructure. The extent of heterogeneities present in the electrode architecture and the adequacy of using the representative elementary volume to capture the effect of complex electrode microstructure on the cell performance were analysed and compared with the 1D model. Finally, the future modelling framework that would aid in optimising the S/C structure for improved and uniform cell performance is discussed.
Global warming from refrigerant HFCs is underestimated by their CO2 equivalent emissions within the century
Authors: Miranda Nicole , Khosla Radhika , Lynch John , Allen Myles , McCulloch Malcolm 
Published: January 2023

Abstract
HFC refrigerant gases are the fastest growing atmospheric GHGs and amongst the most potent. Yet, unlike methane (a short-lived GHG akin to most refrigerants but with significantly lower GWPs), the errors in estimating refrigerant warming based on CO2-equivalent metrics are unknown. We model scenarios to show how the atmospheric responses (i.e., concentrations, forcing and warming) of HFC emissions compare to their CO2-equivalents. Analyzing the remaining warming from HFC emissions if the Kigali Amendment to the Montreal Protocol is achieved, we report that CO2-equivalents omit a warming peak in 2046. A standardized emission step-change shows that calculating warming from CO2-equivalents underestimates the benefits of reducing short-lived HFC emissions by a factor of 4-17 in 2030 (and by 3-5 in 2050). We also demonstrate how natural removals of individual short-lived HFCs are unaccounted when estimating warming from CO2-equivalents. To avoid misrepresentation of global warming from refrigerants, careful consideration of metrics is needed.
Compound heatwave and drought hotspots and their trends in Southeast Australia
Authors: Laz Orpita U , Rahman Ataur , Ouarda Taha B M J 
Published: January 2023

Abstract
Compound extreme natural events cause a significantly larger impact than individual extreme events. Therefore, the urgency of exploring the climatology of compound events is growing. This paper is aimed to identify the current hotspots of compound heatwaves and droughts (CHD) and trends in their occurrence in Southeast Australia. In this context, 61 stations were selected from the study area, and analyses were carried out over the extended summer season of the time period 1971–2021. The hotspots of CHDs in southeast Australia were identified considering both the total count of CHD days and 90th percentile of CHDs during the study period. The study period was divided into two periods 1971–2000 and 2001–2021, to assess the change in hotspots spatially and temporally. Four different attributes of CHDs based on the number, duration, severity and amplitude of CHDs were also calculated, and MK test followed by Sen's slope was adopted to detect the trends in all these four attributes of CHDs. Trends in CHD indices were also calculated for the two periods of 1971–2000 and 2001–2021. For calculating the CHD, EHF was used to identify the heatwaves. In the case of drought identification, SPEI and SPI drought indices were adopted with aggregation of 3 and 6 antecedent months, and three different threshold values were selected to consider three levels of dry conditions, e.g., 0, -0.5 and − 1.0. It has been found that more CHDs occurred on the eastern side of the NSW and Queensland states. Furthermore, the total count of CHD days increased notably during the last two decades. The trends in CHD indices were found to be significant in the recent period (2001–2021), and there was no trend in old period (1971–2000). The findings of this study will help to plan heat and drought related emergency management in the study area.
Characterizing the Recto-Anal Inhibitory Reflex Parameters in Spinal Cord Injured Subjects Compared to Published Healthy Control Values
Authors: Rodriguez Gianna , Armstrong Moira , Baker Jason , Chey William , Saad Richard , Wolgat Ellen , Menees Stacy , Watts Lydia , Ezell Gabrielle 
Published: January 2023

AbstractStudy Design: Cohort study design Objectives: (i) Compare Rectoanal Inhibitory Reflex (RAIR) parameters in spinal cord injury (SCI) patients vs. published healthy control (HC) values (ii) Explore correlations and associations between RAIR parameters and SCI duration, location, and AIS levels. Setting: University of Michigan Methods: Prospective analysis of SCI participants who underwent High Resolution-Anorectal Manometry (HR-ARM). RAIR was tested by inflating 50 ml into the rectal balloon and immediately deflating. RAIR presence = ≥25% of internal anal sphincter pressure [IAS] (mmHg) amplitude reduction. RAIR parameters included: IAS (mmHg), reflex duration [RD] (seconds), and amplitude reduction [AR] (%). Subjects were categorized by AIS level and completeness of injury. Results: 30 SCI (cervical= 20; thoracic= 10) subjects underwent HR-ARM. Demographics included: 80.0% male, 90.0% Caucasian, mean age of 48.3 (14.2) (Range:24-75), and mean BMI of 26.6 (7.0) (Range:16.9–41.2). SCI subjects have significant mean differences, RD (p=<0.001), and AR (p=<0.001), compared to HC (N = 21), but no significant mean differences in IAS pressure. There were no significant correlations between SCI injury duration and IAS (r=-.17;p=NS), RD (r=0.31;p=NS) and AR (r=-0.09;p=NS). No significant mean differences between SCI level and the AIS completeness within RAIR parameters. Conclusion: Cervical and Thoracic SCI subjects have abnormal RAIR parameters compared to healthy controls. As there is minimal scientific evidence demonstrating digital rectal stimulation [DRS] as an effective method of promoting IAS relaxation for stool evacuation, an altered RAIR response on HR-ARM for SCI subjects provides a scientific basis to determine the use of DRS for bowel evacuation.
the Impact of vertical fiscal asymmetry on carbon emissions in China
Authors: Zhao Heng , Liu Jianmin , Wu Jinguang 
Published: January 2023

Abstract
Facing the double pressure of promoting economic growth and achieving the goal of "emission peak" by 2030, China must cut down the carbon emission intensity. Focusing on the typical characteristics of China's financial system arrangement, we theoretically analyze the mechanism of vertical fiscal asymmetry affecting carbon emission intensity through environmental regulation, land finance and local government competition, and use a panel data from 30 Chinese provinces to conduct an empirical examination. The results show: (1) Vertical fiscal asymmetry significantly increases the local carbon emission intensity. After a series of robust tests, such as replacement variables and sample data, the conclusion is still valid. (2) The analysis of regional heterogeneity shows that the influence of vertical fiscal asymmetry in carbon emission intensity is the largest in the central area of China, followed by the eastern provinces, and not evident in the western area. The rise in carbon emission intensity brought on by vertical fiscal asymmetry can be successfully reduced by the central transfer payment. The impact of vertical fiscal asymmetry on carbon emission intensity will be greatly lessened when the central transfer payment surpasses the threshold. (3) The mechanism test shows that vertical fiscal asymmetry increases the carbon emissions intensity by three paths: reducing the intensity of environmental regulation, strengthening local governments' dependence on land finance and local government competition.