bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kelvin-Helmholtz instability in a compressible dust fluid flow
Authors: Kumar Krishan , Bandyopadhyay P. , Singh Swarnima , Dharodi Vikram S. , Sen A. 
Published: March 2023

AbstractWe report the first experimental observations of a single-mode Kelvin-Helmholtz instability in a flowing dusty plasma in which the flow is compressible in nature. The experiments are performed in an inverted $$\Pi$$
Π
-shaped dusty plasma experimental device in a DC glow discharge Argon plasma environment. A gas pulse valve is installed in the experimental chamber to initiate directional motion to a particular dust layer. The shear generated at the interface of the moving and stationary layers leads to the excitation of the Kelvin-Helmholtz instability giving rise to a vortex structure at the interface. The growth rate of the instability is seen to decrease with an increase in the gas flow velocity in the valve and the concomitant increase in the compressibility of the dust flow. The shear velocity is further increased by making the stationary layer to flow in an opposite direction. The magnitude of the vorticity is seen to become stronger while the vortex becomes smaller with such an increase of the shear velocity. A molecular dynamics simulation provides good theoretical support to the experimental findings.
Inhibition of NHE1 transport activity and gene transcription in DRG neurons in oxaliplatin-induced painful peripheral neurotoxicity
Authors: Dionisi Marianna , Riva Beatrice , Delconti Marta , Meregalli Cristina , Chiorazzi Alessia , Canta Annalisa , Alberti Paola , Carozzi Valentina , Pozzi Eleonora , Lim Dmtry , Genazzani Armando A. , Distasi Carla , Cavaletti Guido 
Published: March 2023

AbstractOxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN), one of the major dose-limiting side effects of colorectal cancer treatment, is characterized by both acute and chronic syndromes. Acute exposure to low dose OHP on dorsal root ganglion (DRG) neurons is able to induce an increase in intracellular calcium and proton concentration, thus influencing ion channels activity and neuronal excitability. The Na+/H+ exchanger isoform-1 (NHE1) is a plasma membrane protein that plays a pivotal role in intracellular pH (pHi) homeostasis in many cell types, including nociceptors. Here we show that OHP has early effects on NHE1 activity in cultured mouse DRG neurons: the mean rate of pHi recovery was strongly reduced compared to vehicle-treated controls, reaching levels similar to those obtained in the presence of cariporide (Car), a specific NHE1 antagonist. The effect of OHP on NHE1 activity was sensitive to FK506, a specific calcineurin (CaN) inhibitor. Lastly, molecular analyses revealed transcriptional downregulation of NHE1 both in vitro, in mouse primary DRG neurons, and in vivo, in an OIPN rat model. Altogether, these data suggest that OHP-induced intracellular acidification of DRG neurons largely depends on CaN-mediated NHE1 inhibition, revealing new mechanisms that OHP could exert to alter neuronal excitability, and providing novel druggable targets.
CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death
Authors: Pavlou Sofia , Foskolou Stefanie , Patikas Nikolaos , Field Sarah F. , Papachristou Evangelia K. , Santos Clive D’ , Edwards Abigail R. , Kishore Kamal , Ansari Rizwan , Rajan Sandeep S. , Fernandes Hugo J. R. , Metzakopian Emmanouil 
Published: March 2023

AbstractAccumulation of aggregated and misfolded proteins, leading to endoplasmic reticulum stress and activation of the unfolded protein response, is a hallmark of several neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Genetic screens are powerful tools that are proving invaluable in identifying novel modulators of disease associated processes. Here, we performed a loss-of-function genetic screen using a human druggable genome library, followed by an arrayed-screen validation, in human iPSC-derived cortical neurons. We identified and genetically validated 13 genes, whose knockout was neuroprotective against Tunicamycin, a glycoprotein synthesis inhibitor widely used to induce endoplasmic reticulum stress. We also demonstrated that pharmacological inhibition of KAT2B, a lysine acetyltransferase identified by our genetic screens, by L-Moses, attenuates Tunicamycin-mediated neuronal cell death and activation of CHOP, a key pro-apoptotic member of the unfolded protein response in both cortical and dopaminergic neurons. Follow-up transcriptional analysis suggested that L-Moses provided neuroprotection by partly reversing the transcriptional changes caused by Tunicamycin. Finally, L-Moses treatment attenuated total protein levels affected by Tunicamycin, without affecting their acetylation profile. In summary, using an unbiased approach, we identified KAT2B and its inhibitor, L-Moses, as potential therapeutic targets for neurodegenerative diseases.
AC transmission expansion planning based on self‐organized criticality to mitigate the risk of cascading blackouts
Authors: Tavakoli Mohamad Reza , Ebrahimi Akbar , Latify Mohammad Amin 
Published: March 2023

AbstractThe secular increase of load causes the evolving power system to operate near the critical margins. In such attitudes, the probability of cascading line outages, as the major reason for recent blackouts, is much more than expected. As a result, an innovative approach for optimal AC transmission expansion planning (TEP) to minimize the risk of cascading blackouts is presented in this paper. The proposed multi‐objective AC‐TEP problem minimizes the expected energy not supplied due to the total load shedding imposed on the system to mitigate the risk of cascading line outages along with the total investment and operational costs of the new transmission lines planned to be optimally added to the system. This probabilistic procedure is based on self‐organized criticality and considers the actual aspects of the power system such as reactive power and voltage concerns in the planning stage. The obtained Pareto front set provides the opportunity for the planners to choose the most preferred solution. The proposed method is implemented and verified in the IEEE 118‐bus test system and compared with two types of TEP approaches. The first one is a previously reported version of this work which was a simplified DC model of the problem and the second one is the conventional AC‐TEP model. The obtained results show the benefits of the proposed AC model on the mitigation of cascading line outages in a more realistic framework, considering the impact of reactive power and voltage stability concerns.
Providing an optimal demand response program through placement of automatic switches and energy storage systems to improve the reliability of power distribution networks
Authors: Asadi Morteza , Abedi Seyyed Mostafa , Siahkali Hassan 
Published: March 2023

AbstractCreating highly reliable distribution networks is becoming increasingly vital in today's society. In a similar vein, utilities have issues in properly planning and developing distribution networks, both to reduce their imposed costs and to meet the demands of their consumers. In the presence of Demand Response Program (DRP), this research provides a coordinated architecture that considers automated switches and Energy Storage Units (ESUs) placement with the uncertainty of repair time to enhance the reliability of power distribution network. The suggested objective for optimal placement of automatic switches, ESUs and DRPs is to minimize a combination of reliability index (SAIDI) and Total Cost of system (TC). Customer interruption cost, energy not supplied cost, automated switch investment, ESU investment, ESU participation cost, and DRP cost are all considered as parts of the total cost. The proposed method is used in four different cases on a common reliability test system, followed by numerous sensitivity studies, in order to illustrate applicability and efficiency of suggested method.
Preparation, characterisation, and in vitro cancer‐suppression function of RNA nanoparticles carrying miR‐301b‐3p Inhibitor
Authors: Zhao Junjie , Niu Niu , Yang Fan , Liu Haitao , Qi Weibo 
Published: March 2023

AbstractBackgroundMultidrug resistance is the biggest barrier on the way to chemotherapy for lung adenocarcinoma (LUAD). For some LUAD patients with cisplatin (DDP) resistance and poor prognoses, the authors put forward RNA nanoparticles (NPs) carrying miR‐301b‐3p Inhibitor.MethodsThe NPs were composed of miR‐301b‐3p, A549 aptamer (A549apt), and Cyanine 5 in a bottom‐up manner with a 3‐way‐junction (3WJ) structure. Diameter, assembly process, and morphology of NPs were observed by Dynamic Light Scattering, Native‐Polyacrylamide Gel Electrophoresis, and Atomic Force Microscopy. Cell internalisation, toxicity, proliferation, migration, invasion, and apoptosis were assayed by confocal laser scanning microscope, CCK8, colony formation assay, Transwell, western blot, and flow cytometry.Results3WJ‐apt‐miR was evenly distributed, with diameter of 19.61 ± 0.49 nm and triangular branching structures. The accurate delivery of this NP in vivo was ensured by A549 aptamer featuring specific targeting, with smaller side effects than traditional chemotherapy. Such nanomaterials were effectively internalized by cancer cells, with normal cell activity intact. Cancer cell proliferation, invasion, and migration were suppressed, and DDP sensitivity was enhanced, causing DNA damage and facilitating apoptosis of DDP‐resistant cells.ConclusionBased on RNA self‐assembling, the authors researched the effect of miRNA on DDP sensitivity in LUAD regarding gene regulation. 3WJ‐apt‐miR paves the way for clinical tumour therapy.
Update Breast Cancer 2022 Part 6 – Advanced-Stage Breast Cancer
Authors: Lüftner Diana , Lux Michael P. , Fehm Tanja N. , Welslau Manfred , Müller Volkmar , Schütz Florian , Fasching Peter A. , Janni Wolfgang , Thomssen Christoph , Witzel Isabell , Beierlein Milena , Belleville Erik , Untch Michael , Thill Marc , Ditsch Nina , Aktas Bahriye , Banys-Paluchowski Maggie , Kolberg-Liedtke Cornelia , Wöckel Achim , Kolberg Hans-Christian , Harbeck Nadia , Stickeler Elmar , Tesch Hans , Hartkopf Andreas D. 
Published: March 2023

AbstractLarge-scale study programs on CDK4/6 inhibitors, targeted therapies, and antibody–drug conjugates launched in recent years have yielded results from current studies which are now being published in journals and presented at international conferences. In this context, new results are available from the major CDK4/6 inhibitor studies. Also, an increasing amount of data is being published from large-scale genomic studies on efficacy and resistance mechanisms in patients treated with CDK4/6 inhibitors. These results now form the basis for further research plans to investigate combination therapies and treatment sequencing. Based on the latest published results, sacituzumab govitecan is now available as a second antibody–drug conjugate; this brings an advantage in terms of overall survival for patients with hormone receptor-positive (HRpos)/HER2-negative (HER2neg) breast cancer. In this review article, we summarize the latest developments and place them in context according to the current status of research.
A Systematic Review of Quantitative Methods for Evaluating Electronic Medication Administration Record and Bar-Coded Medication Administration Usability
Authors: Pruitt Zoe M. , Kazi Sadaf , Weir Charlene , Taft Teresa , Busog Deanna-Nicole , Ratwani Raj , Hettinger Aaron Z. 
Published: March 2023

Abstract
Background Although electronic medication administration records (eMARs) and bar-coded medication administration (BCMA) have improved medication safety, poor usability of these technologies can increase patient safety risks.
Objectives The objective of our systematic review was to identify the impact of eMAR and BCMA design on usability, operationalized as efficiency, effectiveness, and satisfaction.
Methods We retrieved peer-reviewed journal articles on BCMA and eMAR quantitative usability measures from PsycInfo and MEDLINE (1946–August 20, 2019), and EMBASE (1976–October 23, 2019). Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we screened articles, extracted and categorized data into the usability categories of effectiveness, efficiency, and satisfaction, and evaluated article quality.
Results We identified 1,922 articles and extracted data from 41 articles. Twenty-four articles (58.5%) investigated BCMA only, 10 (24.4%) eMAR only, and seven (17.1%) both BCMA and eMAR. Twenty-four articles (58.5%) measured effectiveness, 8 (19.5%) efficiency, and 17 (41.5%) satisfaction. Study designs included randomized controlled trial (n = 1; 2.4%), interrupted time series (n = 1; 2.4%), pretest/posttest (n = 21; 51.2%), posttest only (n = 14; 34.1%), and pretest/posttest and posttest only for different dependent variables (n = 4; 9.8%). Data collection occurred through observations (n = 19, 46.3%), surveys (n = 17, 41.5%), patient safety event reports (n = 9, 22.0%), surveillance (n = 6, 14.6%), and audits (n = 3, 7.3%).
Conclusion Of the 100 measures across the 41 articles, implementing BCMA and/or eMAR broadly resulted in an increase in measures of effectiveness (n = 23, 52.3%) and satisfaction (n = 28, 62.2%) compared to measures of efficiency (n = 3, 27.3%). Future research should focus on eMAR efficiency measures, utilize rigorous study designs, and generate specific design requirements.
Monte Carlo study of nanoparticles effectiveness on the dose enhancement when irradiated by protons
Authors: Ahmadi Ganjeh Zahra , Salehi Zaker 
Published: March 2023

Recently, the nanomedicine field has experienced considerable growth in research. The use of nanoparticles to enhance dose in radiation treatment was proposed and their potential effects can be indicated using Monte Carlo calculations. The main goal of this study focused on nanoparticles’ (NPs) effects on dose enhancement due to the low-energy protons because the majority of studies on NPs have been conducted for photon radiations. To investigate the effect of NPs on the Dose Enhancement Factor (DEF), a cell dimension phantom was modeled and spheres of NPs were localized inside that. Different NPs, such as Au, Pt, Ag, I, and Ta2O3, were located in the phantom, and the DEF was calculated by changing the source energy from 3 to 15 MeV. The purpose of investigating the low-energy proton beam is to clarify the effects around the Bragg peak in the presence of nanoparticles. For protons with an energy range of 3–15 MeV, it was discovered that Pt nanoparticles have a greater dose increase coefficient of about 1.8 times compared to the other nanoparticles. The findings indicated that the DEF values substantially depended on the NPs concentration, but that the DEF was not significantly affected by changes in concentration or nanoparticle size. Comparative calculations between water and soft tissue phantoms that were filled with NPs presented a difference of less than 2%. The obtained findings emphasized the importance of NPs and considered details, such as concentration, to demonstrate the potential of nanoparticles in improving treatment using protons.
Potential use of LIAD time-of-flight mass spectrometry for the detection of biomolecules: An example of detecting nucleobases in DNA
Authors: Wang Qiaolin , Xu Lihe , Qin Zhengbo , Yang Xinyan , Zheng Xianfeng 
Published: March 2023

Deoxyribonucleic acid (DNA) carries the genetic information necessary for the synthesis of RNA and proteins; it is a biological macromolecule essential for the development and proper functioning of living organisms and is composed of nucleobases, deoxyribose, and phosphate. The four nucleobases in DNA are adenine (AD), guanine (GU), thymine (TY), and cytosine (CY). Abnormal concentrations of these four nucleobases in an organism have a significant impact on disease diagnosis. Therefore, the qualitative and quantitative detection of these DNA nucleobases in organisms is helpful to diagnose certain diseases. In this work, we report the simultaneous determination of purine (AD, GU) and pyrimidine (TY, CY) nucleobases in DNA using laser-induced acoustic desorption (LIAD) with electron ionization (EI)/time-of-flight mass spectrometry (TOFMS). The purine (MW 120 Da) samples were used as model compounds to assess the sensitivity and quantitative performance of the instrument. Its limits of detection assessed using the LIAD/EI/MS method were ∼0.5–1.2 pg under optimal conditions, and their calibration curves exhibited good linearity (R2 = 0.98). The LIAD/TOFMS was successfully applied in the simultaneous detection of AD, GU, TY, and CY in real DNA samples. The advantage of this technique is simple, fast, and without complex pre-treatment processes. In addition, a quartz-enhanced LIAD (QE-LIAD) source was used to improve the signal strength. The desorption for complex biomolecules shows that the QE-LIAD is still a “gentle” desorption source.
On the syntax of assigning you constructions in Mandarin Chinese
Authors: Huang Rui-heng Ray 
Published: March 2023

Abstract
Assigning you constructions in Mandarin Chinese are special in that they often read like
passives. With this in mind, the goal of this paper is twofold. First, I aim to compare assigning you
constructions with typical passive constructions of bei in Mandarin Chinese. Second, I attempt to seek an
approach that may derive assigning you constructions desirably. The research results are as follows. I have found
that assigning you constructions and bei passives differ both semantically and syntactically. I
argue, contrary to Xiong (2010), that you is not a passive morpheme
since, unlike Mandarin bei passives or English be passives, assigning you
constructions do not always exhibit the initial NP as a Patient or Theme. I also argue against the traditional treatment of
you as a preposition and instead propose that you is a three-place predicate taking an IP
complement. I show that the bi-clausal structure deriving from the verb analysis receives empirical support from binding
phenomena.
Creating a multifaceted corpus of Swedish Sign Language
Authors: Mesch Johanna 
Published: March 2023

Abstract
This chapter discusses the preparatory work of creating a collection of corpora, together functioning as a multifaceted corpus of the same sign language, across three data subsets of signing in different modalities and on different learning levels, namely visual signing (deaf/hard-of-hearing/CODA), tactile signing (deafblind), and L2 signing (hearing second-language learners). This work, led by native signers and based on personal experiences in the research field, involved planning and adapting data collection and annotation of the Swedish Sign Language corpora over time to ensure a corpus infrastructure that is uniform across data sets, compatible with a parallel lexical database, and available as a searchable resource for the public.
W(h)ither the ASL corpus?
Authors: Hochgesang Julie A. , Lepic Ryan , Shaw Emily 
Published: March 2023

Abstract
In this chapter, we discuss logistic and ideological practices used by signed language corpus projects around the world to develop their corpora, starting with Johnston’s early call to develop signed language corpora in 2004. We then outline a brief history of existing American Sign Language (ASL) corpora or corpus-like collections, most of which are specialized and/or inaccessible. We unpack the lessons we have learned as we, North American linguists interested in signed language research and corpora, have sought to create a national-level corpus following the standards set by earlier projects. We conclude that our contexts are somewhat different, and describe projects that we think would be better suited for our ASL communities. In other words, though our dreams of having a single national-level ASL corpus have ‘withered’, we remain optimistic that corpus methods can be used to catalog and analyze the wealth of ASL signing data currently available.
Developing an inventory of handshapes, locations, and movements in Hong Kong Sign Language
Authors: Tang Gladys , Mak Joe , Cheng Ka Yiu , Sze Felix Y.B. 
Published: March 2023

Abstract
In this chapter, we describe how we incorporate the Prosodic Model (Brentari 1998), especially the concept of a hierarchy of nodes with features, into a template for feature coding of sign entries in a lexical database, and how we make use of the features to organize learner’s dictionaries of the respective signed languages. Besides coding prosodic features, other information recorded includes sign category (monomorphemic or polymorphemic), sign type (whether the sign is one-handed or two-handed), the country of origin, gloss and grammatical category. Beginning with Hong Kong Sign Language, Asia SignBank has archived signs from Indonesian Sign Languages, Sri Lanka Sign Languages, Japanese Sign Languages, Ho Chi Ming Sign Languages, and Myanmar Sign Languages. Data input and feature coding were done by Deaf signers trained in sign language analysis and dictionary compilation. Archiving phonological features of individual sign entries also facilitates identification and comparison of phonological and morphological features of signs.
Utterance unit annotation for the Japanese Sign Language Dialogue Corpus
Authors: Bono Mayumi , Okada Tomohiro , Kikuchi Kouhei , Sakaida Rui , Skobov Victor , Miyao Yusuke , Osugi Yutaka 
Published: March 2023

Abstract
This chapter defines ‘utterance units’ and describes their annotation in the Japanese Sign Language (JSL) dialogue corpus, first focusing on how human annotators – native signers of JSL – identify and annotate utterance units, before reporting on part of speech (POS) tagging for JSL and semi-automatic annotation of utterance units. The utterance unit is an original concept for segmenting and annotating movement features in sign language dialogue, based on signers’ native sense. We postulate a fundamental interaction-specific unit for understanding interactional mechanisms (such as turn-taking) in sign language social interactions from the perspectives of conversation analysis and multimodal interaction studies. We explain differences between sentence and utterance units, the corpus construction and composition, and the annotation scheme, before analyzing how JSL native annotators annotated the units. Finally, we show the application potential of this research by presenting two case studies, the first exploring POS annotations, and the second a first attempt at automatic annotation using OpenPose software.
A class of nonlinear wave patterns for (2+1) dimensional coupled integrable Maccari’s system
Authors: Sivatharani B , Subramanian K , Mani Rajan M S , Alagesan T 
Published: March 2023

Abstract
In this paper, with the aid of Truncated Painlevé Approach, (2+1) dimensional Coupled Integrable Maccaris System is investigated. The obtained result contains some arbitrary functions which can be properly selected to study the significance of the mathematical problem. Various kinds of localized solutions such as dromion triplet pairs, dromions, and rogue waves are derived from the obtained solution by means of appropriate arbitrary functions. Using suitable initial parameters, arbitrary functions are chosen to investigate the collisional behavior of the dromion triplet pairs in the two-dimensional plane. We graphically illustrated the nonlinear wave structures with the aid of 3D plots. It is worth noting that these localized nonlinear waves are unstable under various situations.