bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mediators and moderator of the effects of early exposure to intimate partner violence on children’s mental health
Authors: Lee Minji , Kang Sungha , Uribe Ana , Harvey Elizabeth A. , Galano Maria M. 
Published: May 2023

AbstractChildhood intimate partner violence (IPV) exposure increases the likelihood of internalizing and externalizing problems. There is substantial variability in children’s outcomes following IPV exposure, but the reasons behind this are unclear, particularly among preschool-age children. The current study aimed to examine the direct and indirect effects of IPV on preschoolers’ mental health through parent factors (parenting and parental depression), exploring child temperament as a potential moderator of the relation between IPV and child outcomes. Participants were 186 children (85 girls) and their parents living in the United States. Data were initially collected when children were age three, with follow-up at ages four and six. Both parents’ baseline IPV perpetration had adverse effects on child outcomes. Mothers’ IPV was associated with greater paternal depression, paternal overractivity, and maternal laxness, whereas fathers’ IPV was associated with more paternal overreactivity. Only paternal depression mediated the effect of mothers’ IPV on child outcomes. Parenting did not mediate nor did child temperament moderate the relation between IPV and child outcomes. Results shed insight into the need to address parental mental health in families experiencing IPV and underline the need for a further exploration of individual- and family-level mechanisms of adjustment following IPV exposure.
Marital Satisfaction and Mental Health in Adults Over 40 Years Old. Associations with Self-Perceptions of Aging and Stress Related to the COVID–19 Pandemic
Authors: Fernandes-Pires Jose Adrián , Pedroso-Chaparro María del Sequeros , Jiménez-Gonzalo Lucía , Márquez-González María , Cabrera Isabel , Losada-Baltar Andrés 
Published: May 2023

AbstractBeing married has been associated with a better attitude to aging and a buffer against stressful situations, factors that influence mental health. The study analyzes the role of self-perceptions of aging and stress related to the COVID–19 pandemic in the association between marital satisfaction and participants’ mental health. 246 people older than 40 years in a marital/partner relationship were assessed. A path analysis was tested, where self-perceptions of aging and stress from the COVID–19 situation were proposed as mechanisms of action in the association between marital satisfaction and anxious and depressive symptoms. Marital satisfaction, self-perceptions of aging, and stress associated with the COVID–19 pandemic significantly contributed to the model and explained 31% of the variance in participants´ anxious symptomatology, and 42% of the variance in depressive symptomatology. The indirect path of self-perceptions of aging and stress associated with the COVID–19 pandemic in the link between marital satisfaction and anxious and depressive symptoms was statistically significant for both outcome variables. The findings of this study suggest that lower perceived marital satisfaction is associated with higher levels of negative self-perceptions of aging and with higher anxiety and depressive symptoms.Public significance statements:This study suggests that higher marital satisfaction may be a buffer for negative self-perception of aging, and both factors are related with experiencing less stress from COVID–19. These links are associated with less anxious and depressive symptoms.
Effects of Breaking and Non‐Breaking Surface Wave Mixing on the Changjiang River Plume Dynamics in Summer
Authors: Chi Yutao , Rong Zengrui 
Published: May 2023

AbstractA wave‐current coupled model is implemented to investigate the impact of breaking and non‐breaking surface wave mixing on the structure and dynamics of the Changjiang River plume. Two main non‐breaking wave mixing schemes, modifying the turbulent viscosity directly versus adding wave‐induced turbulence production in the turbulence closure model, are incorporated to the Coupled Ocean‐Atmosphere‐WAVE‐Sediment Transport modeling system. Surface wave mixing typically thickens the plume and traps more freshwater in the near‐ and mid‐field regions. The surface turbulent kinetic energy produced by breaking waves corresponds to small wave energy input in fair weather conditions and has a moderate effect on the Changjiang River plume. In contrast, the addition of non‐breaking wave mixing enhances the turbulent viscosity roughly an order of magnitude in the surface layer. Simulations with non‐breaking wave mixing improve the representation of the plume structure compared to models without wave mixing or with only breaking wave mixing. The Changjiang River plume exhibits a north‐south asymmetry in both salinity and current field in summer. Further adding the non‐breaking wave mixing reduces the surface Ekman velocity and lowers the offshore plume expansion rate through interactions between the upwelling favorable winds and the Ekman layer depth. The resulting adjustment to the internal pressure gradient enhances the buoyancy current and magnifies the asymmetric structure of the Changjiang River plume in summer. While the two non‐breaking wave mixing schemes are conceptually different, our modeling experiments suggest that they have similar effects on the plume structure.
Discovery of highly immunogenic spleen-resident FCGR3+CD103+ cDC1s differentiated by IL-33-primed ST2+ basophils
Authors: Kang Myeong-Ho , Hong JungHyub , Lee Jinjoo , Cha Min-Suk , Lee Sangho , Kim Hye-Young , Ha Sang-Jun , Lim Yong Taik , Bae Yong-Soo 
Published: May 2023

AbstractRecombinant interleukin-33 (IL-33) inhibits tumor growth, but the detailed immunological mechanism is still unknown. IL-33-mediated tumor suppression did not occur in Batf3−/− mice, indicating that conventional type 1 dendritic cells (cDC1s) play a key role in IL-33-mediated antitumor immunity. A population of CD103+ cDC1s, which were barely detectable in the spleens of normal mice, increased significantly in the spleens of IL-33-treated mice. The newly emerged splenic CD103+ cDC1s were distinct from conventional splenic cDC1s based on their spleen residency, robust effector T-cell priming ability, and surface expression of FCGR3. DCs and DC precursors did not express Suppressor of Tumorigenicity 2 (ST2). However, recombinant IL-33 induced spleen-resident FCGR3+CD103+ cDC1s, which were found to be differentiated from DC precursors by bystander ST2+ immune cells. Through immune cell fractionation and depletion assays, we found that IL-33-primed ST2+ basophils play a crucial role in the development of FCGR3+CD103+ cDC1s by secreting IL-33-driven extrinsic factors. Recombinant GM-CSF also induced the population of CD103+ cDC1s, but the population neither expressed FCGR3 nor induced any discernable antitumor immunity. The population of FCGR3+CD103+ cDC1s was also generated in vitro culture of Flt3L-mediated bone marrow-derived DCs (FL-BMDCs) when IL-33 was added in a pre-DC stage of culture. FL-BMDCs generated in the presence of IL-33 (FL-33-DCs) offered more potent tumor immunotherapy than control Flt3L-BMDCs (FL-DCs). Human monocyte-derived DCs were also more immunogenic when exposed to IL-33-induced factors. Our findings suggest that recombinant IL-33 or an IL-33-mediated DC vaccine could be an attractive protocol for better tumor immunotherapy.
Porosity evolution of mafic crystal mush during reactive flow
Authors: Gleeson Matthew L. M. , Lissenberg C. Johan , Antoshechkina Paula M. 
Published: May 2023

AbstractThe emergence of the “mush paradigm” has raised several questions for conventional models of magma storage and extraction: how are melts extracted to form eruptible liquid-rich domains? What mechanism controls melt transport in mush-rich systems? Recently, reactive flow has been proposed as a major contributing factor in the formation of high porosity, melt-rich regions. Yet, owing to the absence of accurate geochemical simulations, the influence of reactive flow on the porosity of natural mush systems remains under-constrained. Here, we use a thermodynamically constrained model of melt-mush reaction to simulate the chemical, mineralogical, and physical consequences of reactive flow in a multi-component mush system. Our results demonstrate that reactive flow within troctolitic to gabbroic mushes can drive large changes in mush porosity. For example, primitive magma recharge causes an increase in the system porosity and could trigger melt channelization or mush destabilization, aiding rapid melt transfer through low-porosity mush reservoirs.
The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization
Authors: Skory Robin M. , Moverley Adam A. , Ardestani Goli , Alvarez Yanina , Domingo-Muelas Ana , Pomp Oz , Hernandez Blake , Tetlak Piotr , Bissiere Stephanie , Stern Claudio D. , Sakkas Denny , Plachta Nicolas 
Published: May 2023

AbstractDuring preimplantation development, contractile forces generated at the apical cortex segregate cells into inner and outer positions of the embryo, establishing the inner cell mass (ICM) and trophectoderm. To which extent these forces influence ICM-trophectoderm fate remains unresolved. Here, we found that the nuclear lamina is coupled to the cortex via an F-actin meshwork in mouse and human embryos. Actomyosin contractility increases during development, upregulating Lamin-A levels, but upon internalization cells lose their apical cortex and downregulate Lamin-A. Low Lamin-A shifts the localization of actin nucleators from nucleus to cytoplasm increasing cytoplasmic F-actin abundance. This results in stabilization of Amot, Yap phosphorylation and acquisition of ICM over trophectoderm fate. By contrast, in outer cells, Lamin-A levels increase with contractility. This prevents Yap phosphorylation enabling Cdx2 to specify the trophectoderm. Thus, forces transmitted to the nuclear lamina control actin organization to differentially regulate the factors specifying lineage identity.
Photonic integrated beam delivery for a rubidium 3D magneto-optical trap
Authors: Isichenko Andrei , Chauhan Nitesh , Bose Debapam , Wang Jiawei , Kunz Paul D. , Blumenthal Daniel J. 
Published: May 2023

AbstractCold atoms are important for precision atomic applications including timekeeping and sensing. The 3D magneto-optical trap (3D-MOT), used to produce cold atoms, will benefit from photonic integration to improve reliability and reduce size, weight, and cost. These traps require the delivery of multiple, large area, collimated laser beams to an atomic vacuum cell. Yet, to date, beam delivery using an integrated waveguide approach has remained elusive. Here we report the demonstration of a87Rb 3D-MOT using a fiber-coupled photonic integrated circuit to deliver all beams to cool and trap > 1 ×106atoms to near 200 μK. The silicon nitride photonic circuit transforms fiber-coupled 780 nm cooling and repump light via waveguides to three mm-width non-diverging free-space cooling and repump beams directly to the rubidium cell. This planar, CMOS foundry-compatible integrated beam delivery is compatible with other components, such as lasers and modulators, promising system-on-chip solutions for cold atom applications.
Gate-tunable superconducting diode effect in a three-terminal Josephson device
Authors: Gupta Mohit , Graziano Gino V. , Pendharkar Mihir , Dong Jason T. , Dempsey Connor P. , Palmstrøm Chris , Pribiag Vlad S. 
Published: May 2023

AbstractThe phenomenon of non-reciprocal critical current in a Josephson device, termed the Josephson diode effect, has garnered much recent interest. Realization of the diode effect requires inversion symmetry breaking, typically obtained by spin-orbit interactions. Here we report observation of the Josephson diode effect in a three-terminal Josephson device based upon an InAs quantum well two-dimensional electron gas proximitized by an epitaxial aluminum superconducting layer. We demonstrate that the diode efficiency in our devices can be tuned by a small out-of-plane magnetic field or by electrostatic gating. We show that the Josephson diode effect in these devices is a consequence of the artificial realization of a current-phase relation that contains higher harmonics. We also show nonlinear DC intermodulation and simultaneous two-signal rectification, enabled by the multi-terminal nature of the devices. Furthermore, we show that the diode effect is an inherent property of multi-terminal Josephson devices, establishing an immediately scalable approach by which potential applications of the Josephson diode effect can be realized, agnostic to the underlying material platform. These Josephson devices may also serve as gate-tunable building blocks in designing topologically protected qubits.
Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine
Authors: Garofalo Stefano , Cocozza Germana , Mormino Alessandro , Bernardini Giovanni , Russo Eleonora , Ielpo Donald , Andolina Diego , Ventura Rossella , Martinello Katiuscia , Renzi Massimiliano , Fucile Sergio , Laffranchi Mattia , Mortari Eva Piano , Carsetti Rita , Sciumè Giuseppe , Sozzani Silvano , Santoni Angela , Tremblay Marie-Eve , Ransohoff Richard M. , Limatola Cristina 
Published: May 2023

AbstractThe mechanisms of communication between the brain and the immune cells are still largely unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate lymphoid cells (ILC) 1 in the meningeal dura layer of adult mice. We describe that ILC1/NK cell-derived interferon-γ and acetylcholine can contribute to the modulation of brain homeostatic functions, shaping synaptic neuronal transmission and neurotransmitter levels with effects on mice behavior. In detail, the interferon-γ plays a role in the formation of non-spatial memory, tuning the frequency of GABAergic neurotransmission on cortical pyramidal neurons, while the acetylcholine is a mediator involved in the modulation of brain circuitries that regulate anxiety-like behavior. These findings disclose mechanisms of immune-to-brain communication that modulate brain functions under physiological conditions.
Mechanosensitive non-equilibrium supramolecular polymerization in closed chemical systems
Authors: Lang Xianhua , Huang Yingjie , He Lirong , Wang Yixi , Thumu Udayabhaskararao , Chu Zonglin , Huck Wilhelm T. S. , Zhao Hui 
Published: May 2023

AbstractChemical fuel-driven supramolecular systems have been developed showing out-of-equilibrium functions such as transient gelation and oscillations. However, these systems suffer from undesired waste accumulation and they function only in open systems. Herein, we report non-equilibrium supramolecular polymerizations in a closed system, which is built by viologens and pyranine in the presence of hydrazine hydrate. On shaking, the viologens are quickly oxidated by air followed by self-assembly of pyranine into micrometer-sized nanotubes. The self-assembled nanotubes disassemble spontaneously over time by the reduced agent, with nitrogen as the only waste product. Our mechanosensitive dissipative system can be extended to fabricate a chiral transient supramolecular helix by introducing chiral-charged small molecules. Moreover, we show that shaking induces transient fluorescence enhancement or quenching depending on substitution of viologens. Ultrasound is introduced as a specific shaking way to generate template-free reproducible patterns. Additionally, the shake-driven transient polymerization of amphiphilic naphthalenetetracarboxylic diimide serves as further evidence of the versatility of our mechanosensitive non-equilibrium system.
Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities
Authors: Zhang Wuji , Kedzierski Lukasz , Chua Brendon Y. , Mayo Mark , Lonzi Claire , Rigas Vanessa , Middleton Bianca F. , McQuilten Hayley A. , Rowntree Louise C. , Allen Lilith F. , Purcell Ruth A. , Tan Hyon-Xhi , Petersen Jan , Chaurasia Priyanka , Mordant Francesca , Pogorelyy Mikhail V. , Minervina Anastasia A. , Crawford Jeremy Chase , Perkins Griffith B. , Zhang Eva , Gras Stephanie , Clemens E. Bridie , Juno Jennifer A. , Audsley Jennifer , Khoury David S. , Holmes Natasha E. , Thevarajan Irani , Subbarao Kanta , Krammer Florian , Cheng Allen C. , Davenport Miles P. , Grubor-Bauk Branka , Coates P. Toby , Christensen Britt , Thomas Paul G. , Wheatley Adam K. , Kent Stephen J. , Rossjohn Jamie , Chung Amy W. , Boffa John , Miller Adrian , Lynar Sarah , Nelson Jane , Nguyen Thi H. O. , Davies Jane , Kedzierska Katherine 
Published: May 2023

AbstractHigh-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we found that Australian First Nations peoples elicit effective immune responses to COVID-19 BNT162b2 vaccination, including neutralizing antibodies, receptor-binding domain (RBD) antibodies, SARS-CoV-2 spike-specific B cells, and CD4+ and CD8+ T cells. In First Nations participants, RBD IgG antibody titers were correlated with body mass index and negatively correlated with age. Reduced RBD antibodies, spike-specific B cells and follicular helper T cells were found in vaccinated participants with chronic conditions (diabetes, renal disease) and were strongly associated with altered glycosylation of IgG and increased interleukin-18 levels in the plasma. These immune perturbations were also found in non-Indigenous people with comorbidities, indicating that they were related to comorbidities rather than ethnicity. However, our study is of a great importance to First Nations peoples who have disproportionate rates of chronic comorbidities and provides evidence of robust immune responses after COVID-19 vaccination in Indigenous people.
Dynamic patterns of electroosmosis peristaltic flow of a Bingham fluid model in a complex wavy microchannel
Authors: Hosham H. A. , Thabet Esraa N. , Abd-Alla A. M. , El-Kabeir S. M. M. 
Published: May 2023

AbstractThe purpose of this paper is to present a rigorous analysis of streamline patterns and their bifurcation to a viscoplastic Bingham fluid model that involves heat and mass transfer in an electroosmotic flow through a complex wavy microchannel. The Bingham fluid act as a solid medium in the core layer, which divides the channel into three distinct sections utilized to model the problem as a switched dynamical system between these zones. To track multiple steady states (stagnation points) and related trapping phenomena, we perform both analytical and numerical bifurcation analysis of each subsystem with respect to different physical effects such as electrical double layer thickness and Helmholtz-Smoluchowski velocity. The key feature of the technique presented here is its ability to reveal the peristaltic transport characteristics of the Bingham fluid model in the presence or absence of symmetric flow properties. The primary novelty here is the ability to regulate the location and stability of the equilibrium points in the domain of interest. This leads to the detection of global bifurcations that reflect important dynamic elements of the model. Our results highlighted a new category of complex behavior that controls transitions between qualitatively different transport mechanisms, as well as a class of non-classical trapping phenomena.
Anti-Toxoplasma gondii activity of Trametes versicolor (Turkey tail) mushroom extract
Authors: Sharma Homa Nath , Catrett Jonathan , Nwokeocha Ogechi Destiny , Boersma Melissa , Miller Michael E. , Napier Audrey , Robertson Boakai K. , Abugri Daniel A. 
Published: May 2023

AbstractToxoplasma gondii (T. gondii) infection continues to rise globally in humans and animals with high socioeconomic and public health challenges. Current medications used against T. gondii infection are limited in efficacy, safety, and affordability. This research was conducted to assess the higher fungi extract effect on T. gondii tachyzoites growth in vitro and possibly decipher its mechanism of action. Furthermore, we evaluated the extract's effect on human foreskin fibroblast viability. The methanol extracts of Turkey tail (TT) mushroom was tested against T. gondii tachyzoites growth using an RH-RFP type I strain that expresses red fluorescent protein throughout culture in a dose-dependent manner using a fluorescent plate reader. Similarly, we tested the effect of the extract on host cell viability. We observed that TT extract inhibited tachyzoites growth with a 50% minimum inhibitory concentration (IC50s), IC50 = 5.98 ± 1.22 µg/mL, and 50% cytotoxic concentration (CC50s), CC50 ≥ 100 µg/mL. It was discovered that TT extract induced strong mitochondria superoxide and reactive oxygen species production and disrupted mitochondria membrane potential in T. gondii tachyzoites. Additionally, scanning electron microscopy depicted that TT extract and pyrimethamine (PY) caused a morphological deformation of tachyzoites in vitro. In conclusion, TT methanol extract made up of phytosterols, bioactive sphingolipids, peptides, phenolic acids, and lactones could be a promising source of new compounds for the future development of anti-Toxoplasma gondii drugs. Extracts were non-cytotoxic, even at higher concentrations.
Chemins de drainage-humidification d’un sol limoneux traité au ciment : étude expérimentale et simulations par le modèle de van Genuchten
Authors: Belal Tewfik , Ghembaza Moulay Smaine 
Published: May 2023

Le présent article présente une étude expérimentale sur les chemins de drainage-humidification d’un sol limoneux traité à différents dosages en ciment et compacté à l’Optimum Proctor Normal à température ambiante. Les succions utilisées sont comprises entre 0,05 MPa et 342,63 MPa, et appliquées sur quatre formulations étudiées (sol naturel, sol + 2 % ciment, sol + 4 % ciment et sol + 6 % ciment). À la fin des essais sur les chemins de drainage-humidification, les courbes hydriques du sol traité à différents dosages en ciment nous permettent de déterminer les différents paramètres d’états du sol traité : degré de saturation (Sr), poids volumique sec (γd), indice des vides (e) et teneur en eau (w). La gamme d’imposition de succion ainsi que le dosage en ciment influencent de manière importante le comportement hydrique du matériau étudié. D’autre part, des simulations ont été effectuées en utilisant un modèle hydrique de la littérature ; ces simulations permettent d’illustrer l’effet du traitement sur les paramètres hydriques du sol étudié à savoir : la limite de retrait, la pression de limite de retrait et la pression de désaturation afin de faciliter l’interprétation des résultats expérimentaux obtenus.