bluuebunny/crossref_metadata_2025_split huggingface dataset:
Untersuchungen zum CO2‐Speicherpotenzial von rezyklierten Gesteinskörnungen und Zementproben unter Zwangskarbonatisierung
Authors: Pfleger Marc‐Patrick , Radl Elisabeth , Vill Markus 
Published: May 2023

AbstractDie Herstellung von Beton und insbesondere der darin als Bindemittel enthaltene Zement verursachen einen hohen Anteil der menschlich erzeugten klimawirksamen Emissionen. Studien zeigen, dass die Herstellung von Zement rund 8 % der weltweiten CO2‐Emissionen verursacht, was den akuten Handlungs‐ bzw. Forschungsbedarf unterstreicht. Aufgrund des derzeitigen Gebäude‐ und Infrastrukturbestands und dessen zunehmender Altersstruktur bzw. notwendiger Ersatzbaumaßnahmen nimmt die Menge an verfügbaren Abbruchmaterialien ständig zu. In vielen Fällen besteht dieses Material aus hochwertigem Altbeton, der als rezyklierte Gesteinskörnung im Produktionsprozess wiederverwendet werden kann, um primäre Rohstoffquellen zu schonen. Der größte Teil dieses Betonbruchs ist nicht karbonisiert. Das in dem vorliegenden Beitrag beschriebene Verfahren zur forcierten Karbonatisierung von Betonabbruchmaterial bildet eine Grundlage für die Anwendung in Recyclingbetonen und zielt auf den reduzierten Einsatz von Primärrohstoffen ab. Zudem wurde das Verfahren zur Untersuchung der CO2‐Absorbtionsfähigkeit entwickelt. Durch die Beimischung als Gesteinskörnung im Zuge der Frischbetonproduktion ist der Karbonatisierungsgrad für die Stahlkorrosion oder damit verbundene Probleme irrelevant. Die Versuche zeigen, dass die mit der Produktion von Beton verbundenen CO2‐Emissionen dadurch deutlich reduziert werden können und bereits nach 24 h über 1,3 % der Ausgangsmasse an CO2 gespeichert wurde.
MASON: Betonerhärtung in Schwerelosigkeit – Simulationen mit dem Klinostaten
Authors: Müller Julian , Welsch Torsten , Tell Karsten , Rattenbacher Bernd , Sperl Matthias 
Published: May 2023

AbstractIm Rahmen des Projekts MASON (Material Science on Solidification of Concrete) wird der Einfluss der Erdgravitation auf die Erhärtung von Beton untersucht. Ziel dabei ist es, einerseits Rückschlüsse auf die Eignung von Beton für die Verwendung auf extraterrestrischen Himmelskörpern zu ziehen und andererseits mögliche Erkenntnisse hinsichtlich eines ressourcenschonenderen Einsatzes auf der Erde zu gewinnen. Hierzu wurden vom deutschen ESA‐Astronauten Matthias Maurer im Rahmen der Mission „Cosmic Kiss“ auf der Internationalen Raumstation (ISS) 64 Betonproben in Schwerelosigkeit hergestellt. Diese werden verglichen sowohl mit konventionell unter terrestrischer Schwerkraft (1g) ausgehärten Proben als auch mit Probekörpern, die während der Erstarrungszeit in einem Klinostaten rotiert wurden. Durch die Klinostatrotation wird die Schwerelosigkeit simuliert und mögliche Auftriebs‐ oder Sedimentationsvorgänge im Frischbeton werden minimiert. Das Funktionsprinzip, ein Ansatz, die zutreffende Rotationsgeschwindigkeit abzuschätzen, sowie Ergebnisse einer Studie mit verschiedenen Mischungen und unterschiedlichen Rotationsgeschwindigkeiten werden nachfolgend vorgestellt.
Can you remember silence? Epigenetic memory and reversibility as a site of intervention
Authors: Lloyd Stephanie , Lutz Pierre‐Eric , Bonventre Chani 
Published: May 2023

AbstractJust over 20 years ago, molecular biologists Leonie Ringrose and Renato Paro published an article with a provocative title, “Remembering Silence”, in BioEssays. The article focused on how epigenetic elements could return to their silent state, operationally defined as their epigenetic status before their modulation by experimental or environmental factors. Though Ringrose and Paro's article was on fruit flies and factors affecting embryological growth, the article asked a question of considerable importance to rapidly expanding research in neuroepigenetics on the correlation between trauma and neuropsychiatric risk: If you experience a traumatic event and, as a result, acquire an epigenetic trait that is considered pathological, can you free yourself of that trait? Ultimately, we are interested in how a return to silence is envisioned in neuroepigenetics research, how interventions purported to bring about that silence might function, and what this might mean for people who live in the aftermath of trauma.
Easily recyclable lithium‐ion batteries: Recycling‐oriented cathode design using highly soluble LiFeMnPO4 with a water‐soluble binder
Authors: Du Hao , Kang Yuqiong , Li Chenglei , Zhao Yun , Wozny John , Li Tao , Tian Yao , Lu Jian , Wang Li , Kang Feiyu , Tavajohi Naser , Li Baohua 
Published: May 2023

AbstractRecycling lithium‐ion batteries (LIBs) is fundamental for resource recovery, reducing energy consumption, decreasing emissions, and minimizing environmental risks. The inherited properties of materials and design are not commonly attributed to the complexity of recycling LIBs and their effects on the recycling process. The state‐of‐the‐art battery recycling methodology consequently suffers from poor recycling efficiency and high consumption from issues with the cathode and the binder material. As a feasibility study, high‐energy‐density cathode material LiFeMnPO4 with a water‐soluble polyacrylic acid (PAA) binder is extracted with dilute hydrochloric acid at room temperature under oxidant‐free conditions. The cathode is wholly leached with high purity and is suitable for reuse. The cathode is easily separated from its constituent materials and reduces material and energy consumption during recycling by 20% and 7%, respectively. This strategy is utilized to fabricate recyclable‐oriented LiFeMnPO4/graphite LIBs with a PAA binder and carbon paper current collector. Finally, the limitation of the solubility of the binder is discussed in terms of recycling. This research hopefully provides guidance for recycling‐oriented design for the circular economy of the LIB industry.
Predicting the survival of patients with pancreatic neuroendocrine neoplasms using deep learning: A study based on Surveillance, Epidemiology, and End Results database
Authors: Jiang Chen , Wang Kan , Yan Lizhao , Yao Hailing , Shi Huiying , Lin Rong 
Published: May 2023

AbstractBackgroundThe study aims to evaluate the performance of three advanced machine learning algorithms and a traditional Cox proportional hazard (CoxPH) model in predicting the overall survival (OS) of patients with pancreatic neuroendocrine neoplasms (PNENs).MethodThe clinicopathological dataset obtained from the Surveillance, Epidemiology, and End Results database was randomly assigned to the training set and testing set at a ratio of 7:3. The concordance index (C‐index) and integrated Brier score (IBS) were used to compare the predictive performance of the models. The accuracy of the model in predicting the 5‐year and 10‐year survival rates was compared using the receiver operating characteristic curve, decision curve analysis (DCA) and calibration curve.ResultsThis study included 3239 patients with PNENs in total. The DeepSurv model had the highest C‐index of 0.7882 in the testing set and training set and the lowest IBS of 0.1278 in the testing set compared with the CoxPH, neural multitask logistic and random survival forest models (C‐index = 0.7501, 0.7616, and 0.7612, respectively; IBS = 0.1397, 0.1418, and 0.1432, respectively). Moreover, the DeepSurv model had the highest accuracy in predicting 5‐ and 10‐year OS rates (area under the curve: 0.87 and 0.90). DCA showed that the DeepSurv model had high potential for clinical decisions in 5‐ and 10‐year OS models. Finally, we developed an online application based on the DeepSurv model for clinical use (https://whuh‐ml‐neuroendocrinetumor‐app‐predict‐oyw5km.streamlit.app/).ConclusionsAll four models analyzed above can predict the prognosis of PNENs well, among which the DeepSurv model has the best prediction performance.
Multi‐omic analysis in normal colon organoids highlightsMSH4as a novel marker of defective mismatch repair in Lynch syndrome and microsatellite instability
Authors: Devall Matthew , Ali Mourad W. , Eaton Stephen , Weisenberger Daniel J. , Reilley Matthew J. , Powell Steven M. , Li Li , Casey Graham 
Published: May 2023

AbstractIntroductionLynch syndrome (LS) is a hereditary condition that increases the risk of colorectal (CRC) and extracolonic cancers that exhibit microsatellite instability (MSI‐H). MSI‐H is driven by defective mismatch repair (dMMR), and approximately 15% of nonhereditary CRCs also exhibit MSI‐H. Here, we aimed to better define mechanisms underlying tumor initiation in LS and MSI‐H cancers through multi‐omic analyses of LS normal colon organoids and MSI‐H tumors.MethodsRight (n = 35) and left (n = 23) colon organoids generated from normal colon biopsies at routine colonoscopy of LS and healthy individuals were subjected to Illumina EPIC array. Differentially methylated region (DMR) analysis was performed by DMRcate. RNA‐sequencing (n = 16) and bisulfite‐sequencing (n = 15) were performed on a subset of right colon organoids. CRISPR‐cas9‐mediated editing of MMR genes in colon organoids of healthy individuals was followed by quantitative PCR ofMSH4. The relationship betweenMSH4expression and tumor mutational burden was further explored in three independent tumor data sets.ResultsWe identified a hypermethylated region ofMSH4in both the right and left colon organoids of LS versus healthy controls, which we validated using bisulfite‐sequencing. DMR analysis in three gastrointestinal and one endometrial data set revealed that this region was also hypermethylated in MSI‐H versus microsatellite stable (MSS) tumors.MSH4expression was increased in colon organoids of LS versus healthy subjects and in publicly available MSI‐H versus MSS tumors across four RNA‐seq and four microarray data sets. CRISPR‐cas9 editing ofMLH1andMSH2, but notMSH6, in normal colon organoids significantly increasedMSH4expression.MSH4expression was significantly associated with tumor mutational burden in three publicly available data sets.ConclusionsOur findings implicate DNA methylation and gene expression differences ofMSH4as a marker of dMMR and as a potential novel biomarker of LS. Our study of LS colon organoids supports the hypothesis that dMMR exists in the colons of LS subjects prior to CRC.
Movies on the couch: The MOVIE model of film therapy
Authors: Hamilton Jenny 
Published: May 2023

AbstractFilm therapy, the therapeutic use of movies in psychological therapies, is a growing area of interest to therapists and researchers. This paper discusses the benefits of film therapy and presents a method, the MOVIE model of film therapy, a widely applicable, trauma‐informed framework for individual or group therapy, counsellor education and self‐help. Film or cinema therapy is a highly accessible and relatable method for many diverse groups. The benefits identified include emotional processing, greater ease of dialogue, increased empathy, interpersonal learning, new perspectives and learning skills. Following the model's reflective steps, clients mindfully observe and voice their emotional and psychological responses to movie‐watching; identify how the imagery, characters, themes and story symbolise personal experience; and consider any new possibilities that emerged for their own lives. The model is informed by a practice‐focussed review of literature and draws on methods from mindfulness and experiential and narrative therapies. The steps are widely applicable in a range of settings and can be adapted across counselling modalities. Further research to consider the outcomes of using the model, alongside qualitative research on clients' experiences of working this way with film, is recommended.
How to arrange assortments available in green alternatives: Displaying products by green attributes
Authors: Yao Feisi 
Published: May 2023

AbstractPrevious research has investigated how product display affects consumer choices. However, less is known about the effect of product display on green consumption when products are displayed by green attributes. Through three studies with 610, 661, and 208 valid participants, respectively, the present research demonstrates that displaying products by green attributes render green products more recognizable to the consumer, thereby inducing green choices from among the consideration sets. The positive effect is enhanced by providing green category labels on products. However, the positive effect of product display by green attributes weakens in the case of consumers with high brand familiarity. The findings contribute theoretically and practically to the research on promoting green choice through environmental cues such as product display.
5‐Alpha reductase deficiency; an important cause of 46, XY DSD: Report of three cases within a family
Authors: Noroozi Asl Samaneh , Ibrahimi Reza , Bagheri Sepideh , Lotfi Mojtaba 
Published: May 2023

Key clinical message5‐Alpha reductase deficiency is an important cause of 46, XY disorder of sex development. Timely diagnosis and proper management by a multidisciplinary team can lead to a favorable outcome. Sex assignment should be deferred until puberty because spontaneous virilization occurs and the patient can engage in the decision‐making process.Abstract5‐Alpha reductase deficiency is a genetic disorder causing 46, XY disorder of sex development (DSD). Typical clinical feature is a male with ambiguous genitalia or undervirilization at birth. Here we report three cases of this disorder within a family.
Case report: Transient symptoms of autism spectrum disorder in a 2‐year‐old boy
Authors: Gangi Devon N. , Aishworiya Ramkumar , Hill Monique Moore , Nguyen Dan Thu , Ni Rachel , Parikh Chandni , Solis Erika , Ozonoff Sally 
Published: May 2023

Key Clinical MessageThough early ASD diagnosis is highly stable, this case report describes a rare situation in which symptoms resolved without intervention over a 4 month period. We do not recommend delaying diagnosis in symptomatic children who meet criteria but when major behavioral changes are reported after diagnosis, reevaluation may be beneficial.
Low‐Pressure Sensitive Piezochromic Fluorescence Switching of Tetraphenylethylene‐Anthraquinone
Authors: Wei Yude , Yang Runqing , Cui Guangzhen , Dai Shuting , Pan Guocui , Wang Jing , Ren Haoxuan , Ma Wenyue , Gu Zijian , Zhang Chenchen , Li Guangming , Liu Zhaoyang , Xu Bin , Tian Wenjing 
Published: May 2023

AbstractSensing of low‐pressure signals is of great importance for cutting‐edge technologies. Organic piezochromic molecules offer a promising library of pressure sensitive materials which can be tailor‐designed toward specific requirements. However, very few examples of low‐pressure sensitive piezochromic fluorescent molecules have been obtained till date, and the underlying mechanisms are still in its infancy. Herein, we report highly sensitive piezochromic fluorescent switching under low‐pressure regimes (∼60 kPa) of tetraphenylethylene‐anthraquinone (TPE‐AQ) based on the controlled molecular design and polymorphic phase strategy. The influence of both intramolecular conformation effect and variations of intermolecular stacking modes on the piezochromic property of TPE‐AQ is investigated. The underlying mechanism of the low‐pressure sensitive piezochromic fluorescence switching is demonstrated to be closely related to the loosely packed molecular orientation, as confirmed by X‐ray diffraction measurements combined with simulations. This work provides a way to design highly efficient pressure sensors based on organic molecular systems.
Intrinsically Switchable Electroactive Fluorophores Based on λ5‐Biphosphinines**
Authors: Sangchai Thitiporn , Ledos Nicolas , Vacher Antoine , Cordier Marie , Le Guennic Boris , Hissler Muriel , Jacquemin Denis , Bouit Pierre‐Antoine 
Published: May 2023

AbstractThe synthesis and full characterization of a family of stable λ5‐biphosphinines connected in 4,4‐position through a variety of π‐conjugated bridges is reported. The impact of the π‐bridge on the optical (absorption/emission) and redox properties was investigated using a joint experimental/theoretical approach. In contrast to the π‐extended ones, the λ5‐biphosphinines directly connected through a C−C bond in 4,4‐position display two easily accessible and reversible oxidations highlighting their multi‐stage redox character. The in situ formed radical cations are studied by spectro‐electrochemistry and electron paramagnetic resonance. Finally, electrochemical modulation of fluorescence (electrofluorochromism) was performed and revealed the potential of these intrinsically switchable electroactive fluorophores for further applications as switchable materials.
Azide–Enolate Cycloaddition‐Rearrangement Enables Direct α‐Amination of Amides and Enelactam Synthesis from Esters
Authors: Bell‐Tyrer Joseph J. , Hume Paul A. , Grant Phillip S. , Brimble Margaret A. , Furkert Daniel P. 
Published: May 2023

AbstractInvited for the cover of this issue are Dan Furkert, Joe Bell‐Tyrer and co‐workers at the University of Auckland and Victoria University of Wellington. The image depicts a tandem cycloaddition–rearrangement process delivering a diverse range of molecular frameworks from simple precursors. Read the full text of the article at 10.1002/chem.202300261.
Comparison of two methods for the extraction of ethylglucuronide from hair
Authors: Groff Eleonora , Lucchiari Manuela , Stocchero Giulia , Donini Flora , Marchio Giovanni Michele , Ingenito Francesco , Bertoldi Lucia , Pecoraro Lucia , Bertol Elisabetta , Favretto Donata , Anesi Adriano 
Published: May 2023

AbstractThe aim was the comparison between the Society of Hair Testing (SoHT) consensus for the use of alcohol markers which powdering hair for the extraction of ethylglucuronide (EtG) in water and extraction using the patented M3 Reagent Test kit on cut hair. Hair samples were cut into small segments and washed twice with methanol and diethyl ether. The SoHT‐Consensus entails the extraction of pulverised hair in water. This is obtained by incubation of 25 mg of hair at room temperature overnight and 2 h sonication, even if the overnight incubation is not mandatory. The M3 method entails incubation of 25 mg of cut hair with the M3‐Reagent at 100°C for 60 min. After centrifugation, the supernatant is injected into a liquid chromatography‐tandem mass spectrometry (LC–MS/MS). Samples (191) were collected in the APSS laboratory in Trento, Italy, between 2021 and 2022. The limit of quantification (LOQ) was set at 5 pg/mg for the pulverised and M3‐Reagent methods. Assays showed good linearity above the range of LOQ‐300 pg/mg. Precision (within 20%) values were also obtained using both methods. In the Passing–Bablock linear regression, the final regression curve between M3 (y) and the pulverising method (x) showed good agreement; the Bland–Altman analysis did not show any significant bias between the two methods. The M3‐Reagent method, due to cut hair use, is easy to perform, saves time and allows for a smaller sample quantity loss with use of nondisposable grinding jars for the ball mill to obtain the extraction of EtG.
Offering Lottery Entry as an Incentive for Research Participation Compromises Informed Consent
Authors: Jenkins Simon Paul 
Published: May 2023

ABSTRACTThis paper argues that offering entry into a lottery as an incentive to those who participate in research studies represents a challenge to the principle of informed, coercion‐free consent that is considered an essential ingredient of permissible recruitment to studies. This is, first, because information about the chances of winning in this context is normally unavailable to potential participants and, without this, they cannot accurately weigh up the risks and potential benefits of participation. Second, even when this information is available, such an incentive capitalizes, I contend, on the difficulty of weighing up small probabilities, exploiting the fact that people tend to be beset by cognitive biases that make it challenging to make decisions rationally. The resulting conclusion is that we should not view lotteries as more ethical than simply paying participants, when the latter is feasible.
A Competency Framework for Health Research Ethics Educational Programs: Results from a Stakeholder‐Driven Mixed‐Method Process
Authors: Tackett Sean , Jenn Ng Chirk , Sugarman Jeremy , Daniel Esther Gnanamalar Sarojini , Gopalan Nishakanthi , Tivyashinee  , Kamarulzaman Adeeba , Ali Joseph 
Published: May 2023

ABSTRACTEducational programs are integral to building health research ethics (HRE) capacity, but no outcomes framework exists to guide them. We empirically developed a competency framework for health research ethics education—the Framework for Research Ethics Studies Competencies and Outcomes (FRESCO)—using mixed methods, including group concept mapping and a survey of international experts. FRESCO includes seven competency domains: (1) Foundational Knowledge; (2) Laws, Regulations, Guidelines, and Policies for Research Oversight; (3) Ethical‐Issue Identification, Analysis, and Resolution; (4) Engagement, Communication, and Advocacy; (5) Lifelong Learning, Education, Research, and Scholarship; (6) Coordination, Stewardship, and Responsiveness in HRE Systems; and (7) Impartiality, Honesty, and Responsibility. These domains are detailed in 27 subdomains. Survey respondents rated FRESCO's relevance to HRE highly. FRESCO can be adapted and implemented in educational programs to refine recruitment and selection processes, educational and assessment methods, and performance measures to ensure that HRE educational programs have their intended effects.
Morphological characteristics influence the spatial mixing patterns of shorebirds at Shengjin Lake
Authors: Yu Chao , Zhang Ruilin , Zhou Lizhi , Cheng Lei , Bao Yiwei , Song Yunwei 
Published: May 2023

AbstractThe coexistence of species with similar ecological niches is one of the core interests of community ecology research. However, how functional feeding traits, including bill size and leg length, determine the niche of mixed flocks of shorebird species has seldomly been studied, as well as, microhabitat variables affect the spatial patterns of availability and the quality of patches for wintering. From October 2016 to March 2017 at Shengjin Lake, Anhui Province, China, we recorded 226 scan samples from the different microhabitats and 93 focal animal videos of four common shorebird species: common greenshank, spotted redshank, Kentish plover, and little ringed plover. We found that the species participating in the mixed groups were different in each microhabitat. The results of the overlap index for microhabitats and foraging techniques between the species were consistent with the morphological characteristics of these species. Kentish and little ringed plovers had the highest Pianka's niche overlap index values of 0.95 and 0.98 for microhabitats and foraging techniques, respectively, whereas common greenshank and spotted redshank had values of 0.78 and 0.89, respectively. Common greenshank and spotted redshank used four foraging techniques: a single probe (PR), multiple probes (MPR), a single peck (PE), and multiple pecks (MPE). Kentish and little ringed plovers only used PE and MPE. The mean bill size, mean leg length, and mean foraging frequency were significantly associated with water depth. The mean bill size and mean leg length were both significantly correlated with the mean foraging frequency of shorebirds. The vegetated area was the most important variable for grouping among shorebirds. We concluded that the four species showed differences in their preferred microhabitats and foraging patterns. Interspecific morphological differences, including bill and leg lengths, resulted in niche differentiation. Thus, effective resource allocation by regional species was realized, and a dynamic balance was achieved by the mixed foraging species. The information on foraging behavior and habitat requirements could be useful in the management of water levels in natural areas and conservation of a diversity of wintering shorebirds.