bluuebunny/crossref_metadata_2025_split huggingface dataset:
Additions to the Genus Helicosporium (Tubeufiaceae, Tubeufiales) from China with an Identification Key for Helicosporium Taxa
Authors: Xiao Xing-Juan , Ma Jian , Zhang Li-Juan , Liu Ning-Guo , Xiao Yuan-Pin , Tian Xing-Guo , Luo Zong-Long , Lu Yong-Zhong 
Published: July 2023

Helicosporous hyphomycetes is a group of filamentous fungi that shows promising application prospects in metabolizing bioactive natural compounds. During a study of helicosporous fungi in China, six new helicosporous taxa were collected and isolated from decaying wood in Guangxi Zhuang Autonomous Region, China. Morphological comparisons with multi-gene phylogenetic analyses revealed that these six taxa belong to Helicosporium (Tubeufiaceae, Tubeufiales), and they were recognized as three novel species and were named Helicosporium liuzhouense, H. multidentatum, and H. nanningense. Detailed descriptions and illustrations of the newly discovered taxa and comparisons with similar fungi are provided. In addition, a list and a key to accepted Helicosporium species are provided.
Computation of Matrix Determinants by Cross-Multiplication: A Rethinking of Dodgson’s Condensation and Reduction by Elementary Row Operations Methods
Authors: Protacio Judel Villas 
Published: July 2023

We formulate a more straightforward, symmetry-based technique for manually computing the determinant of any n×n matrix by revisiting Dodgson’s condensation method, as well as strategically applying elementary row (column) operations and the definition and properties of determinants. The result yields a more streamlined algorithm that is generalized through formulas and employs a smaller number of operations and succeeding matrices than the existing methods.
Strategies for Knowledge Sharing Among Rice Farmers: A Ghanaian Perspective
Authors: Kommey Randy , Fombad Madeleine 
Published: July 2023

Purpose: This article investigates knowledge sharing practices amongst rice farmers in Ghana and suggests a strategy for improving knowledge sharing in rice farming communities in Ghana. Design/methodology/approach: This study is underpinned by the pragmatic paradigm where concurrent triangulation mixed-method design was used for the study. Data was gathered with survey and interviews. A total sample of 110 was used, involving 101 survey respondents and 9 interview participants. The survey data was analyse descriptively using Statistical Package for the Social Sciences (SPSS), version 26. The interview finding was analysed using thematic analysis. The findings revealed informal knowledge sharing practices among the rice farmers and suggests a strategy for knowledge sharing that involve partnerships between stakeholders in different sectors, such as government agencies, rice-farming communities; rice production-based NGOs, and researchers. Successful implementation of knowledge sharing would depend on finding and connecting the tools, technologies, and techniques practices. Limitations: The results could not be generalised to knowledge sharing practices among rice framers in Ghana because only three regions were targeted. There is a need for a quantitative comparative study of knowledge sharing by rice farmers in all regions where rice is produced in Ghana. Practical Implications: Rice is an agricultural cereal crop in Ghana and an important source of livelihood for rural poor households. It is consumed and cultivated by many people in the country. When rice farmers engage in efficient knowledge sharing practises knowledge will spread easily among rice farming communities resulting in sustainable agricultural practices that may eradicate hunger and poverty Effective knowledge sharing, offers great potential for addressing the challenges of rice production in Ghana. It will increase rice production, improve the quality of rice yield and safeguard the quality of the natural environment simultaneous. Originality/Value: This article adds to the body of knowledge on knowledge sharing from an agricultural perspective with specific reference to rice farming. Effective knowledge sharing will enhance food security, alleviate climate change challenges, improve nutrition, and promote sustainable agriculture, thus contributing toward the realisation of Goal 2 of the United Nations 2030 Sustainable Development Goals. The findings of this article form part of the finding of the doctoral studies.
Effectiveness Of Floor Cleaning And Wall Cleaning On Growth Of Pathogen Germs In The Current Room Of Dr. Kariadi Hospital, Semarang
Authors: Yunitasari Linawati Neny , Sulistyowati Elyana Sri , Wahyuningtyas Hadiharti 
Published: July 2023

Surface swab examination is carried out to evaluate the cleaning that has been carried out both in detecting the presence of germs in the environment and also for checking the count of germ colonies on the floor surface. The results of the preliminary study by looking at the results of floor swab measurements after general cleaning, especially floor cleaning, obtained data from March - May 2022, 113 outpatient rooms, inpatient and operating rooms and found results that did not meet the quality standards for floor swabs, there were 33 rooms, namely operating room, central nutrition, delivery room, baby room, cardiac catheterization room, mortuary, Rajawali pharmacy, CSSD room, PBRT room, Garuda room, Kepodang and registration room. The aim is to determine the effectiveness of cleaning floors and walls against the growth of pathogenic germs in the Heart Installation. Quantitative research method which is descriptive analytic, test analysis using paired t-test and Wilcoxon. Results: there is no significant difference between cleaning the floor on the growth of pathogenic germs in Pre-post General Cleaning, namely 0.678. Floor Cleaning First-Second 3.5 Hours is 0.259. Keywords: pathogenic germs; floor cleaning; wall cleaningEfektifitas Pembersihan Lantai Dan Pembersihan Dinding Terhadap Pertumbuhan Kuman Patogen Di Ruang Rawat RSUP Dr Kariadi SemarangABSTRAK Pemeriksaan swab permukaan dilakukan untuk mengevaluasi pembersihan yang telah dilakukan baik dalam mendeteksi keberadaan kuman yang ada dilingkungan dan dilakukan juga pemeriksaan hitung koloni kuman permukaan lantai. Hasil studi pendahuluan dengan melihat hasil pengukuran swab lantai setelah dilakukan general cleaning khususnya pembersihan lantai didapatkan data pada bulan Maret - Mei 2022, 113 ruang rawat jalan, rawat inap dan kamar operasi dan ditemukan hasil yang tidak memenuhi syarat baku mutu usap lantai ada 33 ruang yaitu kamar operasi, gizi sentral, ruang bersalin, kamar bayi, ruang keteterisasi jantung, kamar jenazah, farmasi Rajawali, ruang CSSD, ruang PBRT, ruang Garuda, Kepodang dan Ruang pendaftaran. Tujuan untuk mengetahui efektifitas pembersihan lantai dan dinding terhadap pertumbuhan kuman pathogen di Instalasi Jantung. Metode Penelitian kuantitatif yang bersifat deskriptif analitik, analisa uji menggunakan paired t-test dan wilcoxon. Hasil : tidak ada perbedaan signifikan antara pembersihan lantai terhadap pertumbuhan kuman pathogen pada Pre-post General Cleaninng yaitu 0,678. Pembersihan Lantai 3,5 Jam Pertama-Kedua yaitu 0,259. Kata kunci : kuman pathogen; pembersihan lantai; pembersihan dinding
The Role Of Clinic Instructors As Motivators With Student Readiness To Care For Covid-19 Patients
Authors: Tri Sulistiyowati Maria Agustina Ermi , Suryani Maria , Cornalia Johanita Ela , Sagala Agnes Cecila 
Published: July 2023

The Covid-19 pandemic is still ongoing. When nursing students carry out clinical practice, they have the possibility to treat patients with Covid-19. Clinical supervisors as people closest to students have a role as a motivator to motivate students to be ready to treat Covid-19 patients. The aim is to find out the role of the clinical supervisor as a motivator with the readiness of students to treat Covid-19 patients. Analytical descriptive design, with a cross sectional approach. Population of nursing student Elisabeth College of Health Sciences Semarang. A sample of 170 people was taken by total sampling technique. The data was tested using the Kolmogorov Smirnov test. Most of the respondents (85.9%) rated the role of the clinical supervisor as a motivator in the good category and as many as 156 respondents (91.8%) had high readiness to treat Covid 19 patients. The Kolmogorov Smirnov test results obtained a p value of 1,000, there was no relationship the role of the supervisor as a motivator with readiness to care for Covid 19 patients. It is recommended that students remain vigilant and implement health protocols while carrying out clinical nursing practice Keywords: readiness to treat Covid-19 patients; motivator; clinical supervisor rolePeran Instruktur Klinik Sebagai Motivator Dengan Kesiapan Mahasiswa Untuk Perawatan Pasien Covid-19ABSTRAK Pandemi Covid-19 sampai saat ini masih berlangsung. Pada saat mahasiswa keperawatan melaksanakan praktik klinik, mereka memiliki kemungkinan untuk merawat pasien dengan Covid-19. Pembimbing klinik sebagai orang yang terdekat dengan mahasiswa memiliki peran sebagai motivator untuk memotivasi mahasiswa agar siap merawat pasien covid-19. Tujuan untuk mengetahui peran pembimbing klinik sebagai motivator dengan kesiapan mahasiswa merawat pasien Covid-19. Desain deskriptif analitik, dengan pendekatan cross sectional. Populasi mahasiswa keperawatan Sekolah Tinggi Ilmu Kesehatan Elisabeth Semarang. Sampel sebanyak 170 orang diambil dengan teknik total sampling. Data diuji menggunakan uji Kolmogorov Smirnov. Sebagian besar responden (85,9%) menilai peran pembimbing klinik sebagai motivator dalam kategori baik dan sebanyak 156 responden (91,8%) memiliki kesiapan tinggi untuk merawat pasien Covid 19. Hasil uji Kolmogorov Smirnov didapatkan nilai p value 1,000, tidak ada hubungan peran pembimbing sebagai motivator dengan kesiapan merawat pasien Covid 19. Disarankan mahasiswa tetap waspada dan menerapkan protokol kesehatan selama menjalankan praktik klinik keperawatan Kata kunci : kesiapan merawat pasien Covid-19; motivator; peran pembimbing klinik
Pengaruh Budaya Pantangan Terhadap Perawatan Dan Kebutuhan Ibu Nifas Di Wilayah Mekarwangi Kota Bogor
Authors: Aulya Yenny , Siauta Jenny Anna , Munawaroh Nur Sarifah , Mutiariami D Febry 
Published: July 2023

Untuk mengurangi angka kematian ibu dan bayi di Indonesia, penting untuk memberikan perhatian pada masa nifas. Karena masa nifas adalah masa kesulitan bagi ibu dan bayi, sangat penting untuk memberikan perawatan yang tepat. 60% kematian ibu terjadi setelah persalinan, dan 50% kematian pada masa nifas terjadi dalam 24 jam pertama. Banyak ibu nifas di Indonesia yang melakukan pantang makanan pada masa nifas, yang berarti mereka menghindari makanan laut, telur, sayur-sayuran, dan makanan pedas. Hasil penelitian awal yang melibatkan wawancara dengan empat ibu yang sedang hamil menunjukkan bahwa ada pantangan yang dilakukan selama kehamilan. Penelitian ini ditujukan untuk menentukan pengaruh budaya pantangan terhadap perawatan dan kebutuhan ibu nifas di daerah Mekarwangi, Bogor. Penelitian kualitatif ini melibatkan sepuluh ibu yang sedang mengandung selama waktu 7 hingga 40 har10 keluarga, 1 bidan dan 1 paraji. dengan mengambil sempel jenuh menggunakan teknik snowball sampling, dilaksanakan dari desember – februari. Data yang digunakan, yang dikumpulkan melalui metode wawancara, dianalisis melalui analisis konten.Sebagian besar masyarakat Mekarwangi Kota Bogor melakukan budaya pantang makan (makan buah, mie, roti, ikan, telur, dan bakso) dan perawatan nifas (urut, memakai gurita, dan minum jamu). Budaya pantang ini berdampak pada pengeluaran ASI dan penyembuhan luka jahitan.Simpulan: Perawatan masa nifas masyarakat, seperti urut, minum jamu, dan pakai gurita. Budaya pantang makan berdampak pada pengeluaran ASI dan penyembuhan luka jaitan. Budaya pantang makan juga melarang berbagai aktivitas, seperti makan buah, telur, ikan, mie, roti, dan bakso, serta nyanda dan tidur siang. Saran: Untuk memberikan data terbaru membantu meluruskan budaya pada masa nifas yang akan berdampak pada kesehatan. Kata Kunci : pantangan; budaya; perawatan dan kebutuhan nifas; postpartum
Rancang Bangun Aplikasi “PITC” untuk Meningkatkan Minat Ibu Hamil Melakukan Konseling dan Tes HIV
Authors: Ratnaningsih Ester , Maydianasari Lenna , Meliala Dyan Avando 
Published: July 2023

ABSTRAKKasus HIV pada ibu hamil di Kabupaten Sleman pada tahun 2018 ditemukan sebanyak 23 kasus meningkat menjadi 75 kasus pada tahun 2019. Minimnya informasi serta pelayanan kesehatan yang kurang optimal menyebabkan kasus HIV/AIDS meningkat setiap tahun. Media promosi kesehatan diperlukan dengan tujuan untuk mempermudah penyampaian informasi dan pemahaman ibu hamil. Dunia saat ini sudah memasuki era 4.0 dimana terjadinya perkembangan teknologi yang semakin canggih berdampak kepada perkembangan media promosi kesehatan. Salah satunya adalah dengan menggunakan media aplikasi “PITC” berbasis android. Penelitian ini dimaksudkan untuk mengembangkan Aplikasi “PITC” Berbasis Android Sebagai Media Promosi Kesehatan Layanan Provider Initiated Testing And Counseling Bagi Ibu Hamil. Metode penelitian research and development dengan model pengembangan ADDIE dengan tahap analisis kebutuhan, perancangan konsep, dan pengembangan aplikasi. Teknik analisis data yang digunakan adalah teknik analisis deskriptif. Hasil penelitian berdasarkan uji kelayakan media berdasarkan penilaian dari 2 ahli praktisi dengan persentase yaitu 86% dengan kategori sangat layak, dan uji kelayakan pengguna dengan persentase yaitu 80,5 % dengan kategori layak. Data Minat Ibu Hamil melakukan Konseling dan Tes HIV yang dilakukan pengguna (ibu hamil) sebesar 50% ibu hamil mempunyai minat tinggi untuk melakukan konseling dan tes HIV. Kata Kunci: aplikasi; PITC; minat ABSTRACT There were 23 cases of HIV among pregnant women in Sleman Regency in 2018, whic increased to 75 cases in 2019. The lack of information and sub-optimal health services has led to an increase in HIV/AIDS cases every year. Health promotion media are required with the aim of facilitating the delivery of information and understanding of pregnant women. The world has currently entered the industry 4.0 era wherein increasingly sophisticated technological developments have an impact on the development of health promotion media. One example of it is the use of Android-based "PITC" application.This study was intended to develop an Android-based "PITC" application as a health promotion medium for Provider Initiated Testing and Counseling service for pregnant women. The study was research and development method with the ADDIE development model with the stages of needs analysis, concept design, and application development. The data were analyzed using descriptive analysis technique. The results of the study based on the assessment of 2 expert practitioners, the media feasibility rate was 86% which can be involved in the very feasible category. Furthermore, the user feasibility rate was 80.5% which can be involved in the feasible category. Data regarding the Interest of Pregnant Women as users in HIV Counseling and Testing revealed that 50% of pregnant women had a high interest in HIV counseling and testing.Keywords: aplication; PITC; interest
Knowledge and Attitudes towards Antibiotic Usage
Authors: Hejaz Hatem A. 
Published: July 2023

Background: Antibiotic resistance is a global problem, and the World Health Organization (WHO) has made this problem one of its priorities for solving. Repeated and improper use of antibiotics is the main reason for the bacteria's resistance to the drugs.
Objectives: This study aimed to evaluate the knowledge, and attitudes of Palestinians regarding antibiotic usage and awareness about resistance.
Methods: This was a cross-sectional study that targeted Palestinians from different cities. We used an online questionnaire which distributed randomly for data collection. The questionnaire consists of 52 questions to measure the knowledge, attitudes, and awareness of antibiotic use and resistance. Statistical Package for the Social Sciences (SPSS) version 25 was used to analyze the data collected.
Results: A total of 744 participated in the study and completed the questionnaire, and the majority of them (60.5 %; n= 450 out of 744) were from the Hebron Governorate. The major of the respondents also were females (n= 653, 87.8%) and their age between 20-35 years old (n= 498, 66.9%) with a bachelor degree (n= 502, 67.5%). The majority of them (75.5%, n= 560) think that antibiotics should be given only by prescription, and about half of the people (52%= n= 387) believe that antibiotics are not safe. Most participants relied on the physician for dispensing the antibiotic (60.1%, n= 455) but the same percentage of them use leftover antibiotics that have been used previously. Four hundred eighty-three (65%, n= 483) who completed the questionnaire heard about the antibiotic resistance term from medical staff, and their main primary sources of information about antibiotics and medicines were from health staff too (50%, n= 371), then internet (25%, n= 185). Some people (16%, n= 119) mentioned that pharmacists have a role in educating them and providing all the necessary information, or advice about the use of medicines and the dangers of medication misuse. Most of the participants obtained the antibiotics by prescription from a doctor (n= 339, 45.6%), then from the Pharmacist (n= 91, 12.2%), and 63 persons (8.5%) purchases them on their own. Quite a high number of participants (n= 348, 46.8%) stop taking antibiotics when they start feeling better. According to the results obtained, social media was the primary source of information regarding antibiotic resistance.
Conclusions: Higher education, younger age, gender, profession, and a high monthly income were associated significantly with good knowledge and a positive attitude toward antibiotic use. Educational interventions for appropriate antibiotic use are needed all the time and enforcing antibiotics regulations should be also considered to reduce antibiotic resistance.
Progress in the Design and Development of Phosphoinositide-3-Kinase (PI3Kα) Inhibitors
Authors: Sabbah Dima A. 
Published: July 2023

Background: The phosphatidylinositol 3-kinase (PI3Kα) has been spotlighted as a potential oncogene and therapeutic target for anticancer drug design.
Objective: Target compounds were designed employing ligand- and structure-based drug design approaches to address the effect of the compounds’ backbones and functionalities on their biological activity.
Methods: Synthesis of the targeted compounds, biological evaluation tests against human cancer cell lines, and molecular docking studies.
Results: Fortunately, 20 novel series of diverse scaffolds were prepared and characterized by means of FT-IR, 1H and 13C NMR, HRMS, and elemental analysis. In addition, the identity of one core nucleus was successfully interpreted with the aid of X-ray crystallography. Biological activity of prepared compounds was investigated in vitro against human cancer cell lines. Results that these compounds inhibit cell proliferation and induce apoptosis through an increase in caspase-3 activity and a decrease in DNA cellular content. Furthermore, ligand-based pharmacophore modeling showed that the newly synthesized analogues match PI3Kα inhibitors fingerprint and the molecular docking studies against PI3Kα revealed that the analogues fit PI3Kα kinase catalytic domain and form H-bonding with key binding residues.
Conclusion: The harvested series exhibited a potential PI3Kα inhibitory activity in human cancer cell lines.
Crosslinking of Water-Soluble Cyclodextrin with Hyaluronic Acid for Targeted Drug Delivery
Authors: Adaileh Fedaa 
Published: July 2023

Introduction: Most of the cytotoxic anticancer drugs belong to substances with both low solubility in aqueous fluids and poor cellular uptake, which lead to lack of specific therapy with apparent side effects. Therefore, there is a need to develop a novel drug delivery that can remotely and selectively release their payload. Curcumin(CUR) is an antibiotic, also a powerful inhibitor of the proliferation of several tumor cells.
Aims: The aim of the present work is to highlight and discussed hyaluronic acid (HA ) to be grafted with Mono-6-deoxyl-6-ethylenediamino-γ-cyclodextrin (ɣ-CD-EDA) to shape a hydrogel that ought to structure inclusion complexes with curcumin, bettering its water-solubility and serving as a model drug delivery system
Methods: Distinct copolymers had been organized HA grafted with ɣ-cyclodextrin (ɣ-CD-EDA) to form a hydrogel with various HA: ɣ-CD-EDA ratios and characterized,
by means of 1H-NMR spectroscopy, zeta potential, Thermogravimetry analysis) TGA) Differential scanning calorimetry (DSC), and transmission electron microscopy (TEM). Furthermore, drug loading Encapsulation efficiency (EE%), and release kinetics, and stability. Also, cytotoxicity and uptake were assessed by flow cytometry, MTT assay and confocal laser microscopy. Wound healing activity was once improved using three cell MDA-MB-231, MCF-7, and fibroblast. Measuring the effect of HA-γ-CD-EDA1-CUR, γ-CD-EDA1-CUR, and CUR free on the Production and Secretion of inflammatory cytokines
Result: CUR loading potential used to be at once correlated with extended HA-ɣ-CD-EDA composition and morphological adjustments have been discovered upon CUR binding. The host substances and their CUR inclusion complexes are no longer cytotoxic, and consequently beneficial for CUR and drug delivery. Moreover, HA-γ-CD-EDA1-CUR, γ-CD-EDA1-CUR, and CUR wound healing activity was once improved, and human promonocytic THP-1 cells produce inflammatory mediators such as IL-1β, IL10,IL8, TNF-α,IRAKI and IL6 results showed that the combination HA-γ-CD-EDA1-CUR could be suitable to reduce inflammation and the complex promoted the anti-inflammatory effect by the inhibition of inflammatory mediators.
Conclusion: HA grafted with ɣ-cyclodextrin (ɣ-CD-EDA) to form a hydrogel was designed, formulated, and full characterized. Nanoparticles were stable at physiological pH and have released payload. Encapsulation of CUR into polymer increased its selectivity, distribution, and accumulation into the cancer cells. HA-CD-EDA1conjugated curcumin if incorporated in suitable matrix has a potential utility for treatment of wound, and down regulation in THP-1 cells.
The Immunostimulatory Effect of Probiotic Conditioned Medium on RAW264.7 Murine Macrophages
Authors: Barakat Muna , Al-Najjar Mohammad AA , Abdulrazzaq Shaymaa , Talib Wamidh H. , Athamneh Tamara 
Published: July 2023

Background: Probiotics are a mixture of good live bacteria and/or yeasts that naturally survive in our bodies. Recently, loads of studies have focused on their role in the immune system and digestive tract. Accordingly, there are many commercially available probiotic products in the market. This study examines the immunostimulatory effect of commercially available-probiotic conditioned medium (PCM) on RAW264.7 murine macrophages.
Methods: Probiotic conditioned medium has been prepared by culturing the commercially available probiotic in a cell culture medium overnight at 37°C, followed by centrifugation and filter-sterilization to be tested on RAW264.7 murine macrophages. The immunostimulatory effect of different ratios (50, 75, 100) of PCM was examined using MTT assay, pro-inflammatory cytokine (tumor necrosis factor TNF-alpha) production in macrophages., migration, and Phagocytosis assays.
Results: At all the examined PCM ratios, the percentages of cell viability were >80%. Regarding the migration scratch, TNF-alpha and phagocytosis assays, PCM demonstrated a concentration-dependent pattern in the immunostimulatory effect. However, the ratio of 100 PCM illustrated a significant (p-value<0.05) stimulatory effect compared to the positive and negative control.
Conclusion: The findings of this study confirm the stimulatory activity of probiotic conditioned medium, which may contribute directly to the immune-boosting effect of the probiotic supplements.