bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammatory reaction in eyes with late in‐the‐bag intraocular lens dislocation
Authors: Medin Helle , Kure Ingeborg Slørdahl Hjort , Dalby Marius , Kristianslund Olav , Drolsum Liv 
Published: June 2023

AbstractPurposeTo investigate the inflammatory reaction in eyes with late in‐the‐bag intraocular lens (IOL) dislocation.MethodsThis prospective clinical study with fellow‐eye comparison consists of 76 of the patients (76 eyes) with late in‐the‐bag IOL dislocation enrolled in the LION trial. The main outcome measure was anterior chamber flare before surgery measured with a laser flare meter in photon counts per millisecond (pc/ms). The dislocation was graded as 1 (small: optic still covering the visual axis), 2 (optic equator close to the visual axis) or 3 (optic decentred beyond the visual axis, but the IOL–capsule complex partly visible in the pupillary area). The secondary aim was to compare intraocular pressure (IOP) before surgery.ResultsFlare levels before surgery were significantly higher in the dislocation eyes than in the fellow eyes with a median flare of 21.5 (range 5.4–135.7) pc/ms versus 14.1 (2.0–42.9) pc/ms, respectively (p ˂ 0.001). A regression analysis of log‐transformed flare values showed that the dislocation eyes had a non‐significant tendency towards higher flare in dislocation grade 1 with a median flare of 24.6 (5.4–135.7) pc/ms compared to grade 2; 19.6 (6.5–41.5) pc/ms (p = 0.06), and no significant difference compared to grade 3; 19.4 (10.2–53.5) pc/ms (p = 0.47). The IOP was significantly higher in the dislocation eyes than in the fellow eyes (p ˂ 0.001).ConclusionsEyes with late in‐the‐bag IOL dislocation had increased flare levels compared to their fellow eyes. This suggests that inflammation is part of the clinical picture of late in‐the‐bag IOL dislocation.
Letter: Post‐COVID‐19 disorders of gut‐brain interaction (DGBI)—Just post‐infectious or a multi‐faceted entity?
Authors: Siah Kewin T. H. , Mahadeva Sanjiv 
Published: June 2023

LINKED CONTENTThis article is linked to Marasco et al papers. To view these articles, visit https://doi.org/10.1111/apt.17513 and https://doi.org/10.1111/apt.17561
Letter: Post‐COVID‐19 functional dyspepsia and irritable bowel syndrome—Authors' reply
Authors: Marasco Giovanni , Maida Marcello , Cremon Cesare , Barbaro Maria Raffaella , Stanghellini Vincenzo , Barbara Giovanni 
Published: June 2023

LINKED CONTENTThis article is linked to Marasco et al papers. To view these articles, visit https://doi.org/10.1111/apt.17513 and https://doi.org/10.1111/apt.17539
Editorial: The US burden of HRS‐AKI—Putting numbers to the problem: Authors' reply
Authors: Verma Nipun , Singal Ashwani K. 
Published: June 2023

LINKED CONTENTThis article is linked to Singal et al papers. To view these articles, visit https://doi.org/10.1111/apt.17232 and https://doi.org/10.1111/apt.17541
iFUNDit: Visual Profiling of Fund Investment Styles
Authors: Zhang R. , Ku B. K. , Wang Y. , Yue X. , Liu S. , Li K. , Qu H. 
Published: June 2023

AbstractMutual funds are becoming increasingly popular with the emergence of Internet finance. Clear profiling of a fund's investment style is crucial for fund managers to evaluate their investment strategies, and for investors to understand their investment. However, it is challenging to profile a fund's investment style as it requires a comprehensive analysis of complex multi‐dimensional temporal data. In addition, different fund managers and investors have different focuses when analysing a fund's investment style. To address the issue, we proposeiFUNDit, an interactive visual analytic system for fund investment style analysis. The system decomposes a fund's critical features into performance attributes and investment style factors, and visualizes them in a set of coupled views: a fund and manager view, to delineate the distribution of funds' and managers' critical attributes on the market; a cluster view, to show the similarity of investment styles between different funds; and a detail view, to analyse the evolution of fund investment style. The system provides a holistic overview of fund data and facilitates a streamlined analysis of investment style at both the fund and the manager level. The effectiveness and usability of the system are demonstrated through domain expert interviews and case studies by using a real mutual fund dataset.
Inhibition of ANXA2 activity attenuates epileptic susceptibility and GluA1 phosphorylation
Authors: Ma Limin , Wu Qingyuan , Yuan Jinxian , Wang You , Zhang Peng , Liu Qiankun , Tan Dandan , Liang Minxue , Chen Yangmei 
Published: June 2023

AbstractIntroductionAnnexin A2 (ANXA2) participates in the pathology of a variety of diseases. Nevertheless, the impact of ANXA2 on epilepsy remains to be clarified.AimsHence, the study aimed at investigating the underlying role of ANXA2 in epilepsy through behavioral, electrophysiological, and pathological analyses.ResultsIt was found that ANXA2 was markedly upregulated in the cortical tissues of temporal lobe epilepsy patients (TLE), kainic acid (KA)‐induced epilepsy mice, and in a seizure‐like model in vitro. ANXA2 silencing in mice suppressed first seizure latency, number of seizures, and seizure duration in behavioral analysis. In addition, abnormal brain discharges were less frequent and shorter in the hippocampal local field potential (LFP) record. Furthermore, the results showed that the frequency of miniature excitatory postsynaptic currents was decreased in ANXA2 knockdown mice, indicating that the excitatory synaptic transmission is reduced. Co‐immunoprecipitation (COIP) experiments demonstrated that ANXA2 interacted with the α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) subunit GluA1. Moreover, ANXA2 knockdown decreased GluA1 expression on the cell surface and its phosphorylation onserine 831 and serine 845, related to the decreased phosphorylation levels mediated by protein kinases A and C (PKA and PKC).ConclusionsThis study covers a previously unknown and key function of ANXA2 in epilepsy. These findings indicate that ANXA2 can regulate excitatory synaptic activity mediated by AMPAR subunit GluA1 to improve seizure activity, which can provide novel insights for the treatment and prevention of epilepsy.
Eye Movements, Pupil Dilation, and Conflict Detection in Reasoning: Exploring the Evidence for Intuitive Logic
Authors: Purcell Zoe A. , Roberts Andrew J. , Handley Simon J. , Howarth Stephanie 
Published: June 2023

AbstractA controversial claim in recent dual process accounts of reasoning is that intuitive processes not only lead to bias but are also sensitive to the logical status of an argument. The intuitive logic hypothesis draws upon evidence that reasoners take longer and are less confident on belief–logic conflict problems, irrespective of whether they give the correct logical response. In this paper, we examine conflict detection under conditions in which participants are asked to either judge the logical validity or believability of a presented conclusion, accompanied by measures of eye movement and pupil dilation. The findings show an effect of conflict, under both types of instruction, on accuracy, latency, gaze shifts, and pupil dilation. Importantly, these effects extend to conflict trials in which participants give a belief‐based response (incorrectly under logic instructions or correctly under belief instructions) demonstrating both behavioral and physiological evidence in support of the logical intuition hypothesis.
Heart transplant in a Sars‐CoV‐2 positive recipient: Management protocol of the world's first case
Authors: Giovannico Lorenzo , Ramirez Antonio D'Errico , Parigino Domenico , Fischetti Giuseppe , Losito Concetta , Lenoci Sergio , Fiore Giuseppe , Civita Antonio , Bavaro Davide F. , Saracino Annalisa , Grasso Salvatore , Bottio Tomaso , Milano Aldo Domenico 
Published: June 2023

AbstractThe advent of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in China at the end of 2019 has developed into a global outbreak, and COVID‐ 19 is an ongoing major public health issue. During the pandemic, transplant programs had to devise strategies to deal with the possibility of COVID‐19‐positive donors and recipients. We describe the case of a heart transplant recipient who tested positive with the SARS‐ CoV2 swab upon admission to our Unit of Cardiac Surgery when a suitable donor became available. Given his clinical status of end‐stage heart failure and the absence of imaging and clinical signs suggestive of COVID‐19, and his having been vaccinated with three doses, we decided to proceed with the transplant.
Selective perforant‐pathway atrophy in Huntington disease: MRI analysis of hippocampal subfields
Authors: Wibawa Pierre , Walterfang Mark , Malpas Charles B. , Glikmann‐Johnston Yifat , Poudel Govinda , Razi Adeel , Hannan Anthony J. , Velakoulis Dennis , Georgiou‐Karistianis Nellie 
Published: June 2023

AbstractIntroductionWhile individuals with Huntington disease (HD) show memory impairment that indicates hippocampal dysfunction, the available literature does not consistently identify structural evidence for involvement of the whole hippocampus but rather suggests that hippocampal atrophy may be confined to certain hippocampal subregions.MethodsWe processed T1‐weighted MRI from IMAGE‐HD study using FreeSurfer 7.0 and compared the volumes of the hippocampal subfields among 36 early motor symptomatic (symp‐HD), 40 pre‐symptomatic (pre‐HD), and 36 healthy control individuals across three timepoints over 36 months.ResultsMixed‐model analyses revealed significantly lower subfield volumes in symp‐HD, compared with pre‐HD and control groups, in the subicular regions of the perforant‐pathway: presubiculum, subiculum, dentate gyrus, tail, and right molecular layer. These adjoining subfields aggregated into a single principal component, which demonstrated an accelerated rate of atrophy in the symp‐HD. Volumes between pre‐HD and controls did not show any significant difference. In the combined HD groups, CAG repeat length and disease burden score were associated with presubiculum, molecular layer, tail, and perforant‐pathway subfield volumes. Hippocampal left tail and perforant‐pathway subfields were associated with motor onset in the pre‐HD group.ConclusionsHippocampal subfields atrophy in early symptomatic HD affects key regions of the perforant‐pathway, which may implicate the distinctive memory impairment at this stage of illness. Their volumetric associations with genetic and clinical markers suggest the selective susceptibility of these subfields to mutant Huntingtin and disease progression.
Gender inequality in academic leadership: Bangladesh, China and Finland
Authors: Kohtamäki Vuokko , Zheng Gaoming , Jinia Nasrin 
Published: June 2023

AbstractThe importance of gender equality in academic leadership has been widely recognised, yet this issue has been underexplored outside the Anglo‐Saxon countries. In this systematic review, we analysed 62 academic articles on women's academic leadership in Bangladesh (15), China (17) and Finland (30), published between 2000 and 2021. Our study revealed that research on gender‐related academic leadership is still underdeveloped across the three countries, particularly in Bangladesh. Most studies have focussed on the barriers that hinder women from attaining academic leaders' roles. Our review results highlight the role of societal and cultural factors that contribute to the differences in the levels of gender equality in university leadership across the three countries. However, the men‐dominated structure and culture in higher education pose the major obstacle for women in reaching leaders' positions in all three countries.
The impact of climate change on country and community and the role of mental health professionals working with Aboriginal communities in recovery and promoting resilience
Authors: Upward K. , Usher K. , Saunders V. 
Published: June 2023

AbstractThis paper emerged from discussions between the authors about our shared and different perspectives of climate change and its impact on the social, emotional, physical, spiritual and cultural wellbeing of Aboriginal Peoples and mental health services in a rural region, heavily impacted in recent years by bushfires and floods. Here we discuss, from the lead authors personal perspective as a Gamilaraay Woman, the experience of Solastalgia as a critical impact of climate change on wellbeing. Specifically, we discuss the relationship of a connection to country from a Gamilaraay, first person perspective through a series of diary entries from the lead author. Authors are researchers from different cultural backgrounds, connected through a medical research futures fund research project, to promote resilience within Aboriginal communities and the health services sector in the New England, North West region. The lead author has cultural connections to some of the communities we work with and our work is informed by these connections. While this paper was written to express an Aboriginal perspective on climate change and wellbeing, it reflects our shared perspectives of how disasters such as bushfires impact the wellbeing of Aboriginal peoples. We also explore the connection between the impact of localised, recurring natural disasters and the increasing demands on mental health services in regional and rural areas and discuss what this means with Aboriginal and non‐Indigenous mental health nurses and researchers working in regional and rural areas where access to mental health services often poses considerable challenges. From our perspective, mental health research and nursing play an important role in walking alongside Aboriginal Peoples as we explore, respond and create resilience to the ever‐present influence that climate change is having on our lives, communities, country and workplaces.
One‐pot hydrothermal synthesis of Cu2Te/NiTe nanocomposite materials: A structural, morphological, and optical study
Authors: Supriya Swikruti , Das Subhashree , Senapati Subrata , Naik Ramakanta 
Published: June 2023

AbstractDue to various structural and optical properties, metal chalcogenide nanomaterials are favorable candidates for different optoelectronic applications. In the current report, Cu2Te/NiTe nanocomposites were synthesized via the facile hydrothermal method. With the variation of concentration of Cu and Ni, various materials had been prepared along with pure Cu2Te and NiTe. The observed several vibrational modes in the material through the Raman spectroscopy are well agreed with the appearing phases. The morphological study confirmed the nanostructures are combination of nanoparticles with sheets. The size of nanoparticles varied in the range of 66–34 nm. The absorbance spectra of the nanocomposite exhibit a blueshift and support the enhancement in the optical bandgap. The value of bandgap energy of the composite samples has been noted in the range of 1.8–2.2 eV. This bandgap range enables the material for various optoelectronic applications such as solar cell and other photovoltaic devices. Thermal analysis of the material demonstrates the presences of several endothermic and exothermic peaks. Thus, several studies on the material prevail its various applicability as optoelectronics as well as other thermal application.
Limitations on the sintering of graded particle systems
Authors: Delia Daniel J. , Carty William M. 
Published: June 2023

AbstractImprovement of compact density is commonly achieved by blending coarse and fine particles, but these compacts will not densify without the presence of a significant amount of liquid phase. It was proposed that two step sintering (TSS) could be applied to sinter the fine particle matrix, potentially accommodating the presence of inclusions of large particles. This hypothesis was false. Compacts were prepared with similar green density but with different ratios of coarse, medium, and fine particles and then subjected to TSS. The results indicated that constrained sintering limits densification on both ends of the particle packing spectrum: A fine particle matrix containing large particles fails to densify because the matrix cannot shrink around the inclusion; the densification of fine particle pockets in a skeletal network composed of large particles does not allow sufficient shrinkage in the pockets of small particles.
Multiple myeloma patients undergoing chemotherapy: Which symptom clusters impact quality of life?
Authors: Zeng Lihong , Huang Hui , Qirong Chen , Ruan Chunhong , Liu Yaqi , An Wenhong , Guo Qinqin , Zhou Jiandang 
Published: June 2023

AbstractAims and ObjectivesTo identify symptom clusters and examine their association with health‐related quality of life.BackgroundMultiple myeloma patients undergoing chemotherapy suffer from disease symptoms and adverse effects during the course of the disease. However, single symptom management has little effect, and symptom management for these patients remains challenging. Symptom clusters open a new perspective and provide important clues for symptom management.DesignA cross‐sectional study.MethodParticipants were invited to complete the Chinese version of the Memorial Symptom Assessment Scale and Quality of Life Questionnaire‐core 30. Appropriate indicators were used for descriptive statistics. Principal component analysis was used to identify symptom clusters. Associations between symptom clusters and quality of life were examined with Pearson correlation coefficients, Pearson correlation matrix and multiple linear regression. This study was reported following the STROBE checklist.ResultsA total of 177 participants were recruited from seven hospitals in this study. We identified self‐image disorder, psychological, gastrointestinal, neurological, somatic and pain symptom clusters in multiple myeloma patients with chemotherapy. Approximately 97.65% of patients suffer from multiple symptom clusters. The pain, psychological and gastrointestinal symptom clusters have negatively influence on health‐related quality of life. The strongest association was found with the pain symptom cluster.ConclusionMost of multiple myeloma patients suffer from multiple symptom clusters. When improving the multiple myeloma patients' health‐related quality of life, the clinical staff should prioritise relieving the pain symptom cluster.Relevance to Clinical PracticeWhen multiple myeloma patients undergoing chemotherapy suffer from multiple symptom clusters, nurses should prioritise relieving the pain symptom cluster to improve their health‐related quality of life. When drawing up and providing interventions, nurses should focus on the correlation among symptoms rather than single symptom. By relieving one symptom in a given cluster, other symptoms within the same symptom cluster may also be relieved.
Comparison of the impact of two key fungal signalling pathways on Zymoseptoria tritici infection reveals divergent contribution to invasive growth through distinct regulation of infection‐associated genes
Authors: Child Harry T. , Deeks Michael J. , Rudd Jason J. , Bates Steven 
Published: June 2023

AbstractThe lifecycle of Zymoseptoria tritici requires a carefully regulated asymptomatic phase within the wheat leaf following penetration of the mesophyll via stomata. Here we compare the roles in this process of two key fungal signalling pathways, mutants of which were identified through forward genetics due to their avirulence on wheat. Whole‐genome resequencing of avirulent Z. tritici T‐DNA transformants identified disruptive mutations in ZtBCK1 from the kinase cascade of the cell wall integrity (CWI) pathway, and the adenylate cyclase gene ZtCYR1. Targeted deletion of these genes abolished the pathogenicity of the fungus and led to similar in vitro phenotypes to those associated with disruption of putative downstream kinases, both supporting previous studies and confirming the importance of these pathways in virulence. RNA sequencing was used to investigate the effect of ZtBCK1 and ZtCYR1 deletion on gene expression in both the pathogen and host during infection. ZtBCK1 was found to be required for the adaptation to the host environment, controlling expression of infection‐associated secreted proteins, including known virulence factors. Meanwhile, ZtCYR1 is implicated in controlling the switch to necrotrophy, regulating expression of effectors associated with this transition. This represents the first study to compare the influence of CWI and cAMP signalling on in planta transcription of a fungal plant pathogen, providing insights into their differential regulation of candidate effectors during invasive growth.
ZmSPL13andZmSPL29act together to promote vegetative and reproductive transition in maize
Authors: Yang Juan , Wei Hongbin , Hou Mei , Chen Lihong , Zou Ting , Ding Hui , Jing Yifeng , Zhang Xiaoming , Zhao Yongping , Liu Qing , Heng Yueqin , Wu Hong , Wang Baobao , Kong Dexin , Wang Haiyang 
Published: June 2023

SummaryFlowering time is a key agronomic trait determining environmental adaptation and yield potential of crops. The regulatory mechanisms of flowering in maize still remain rudimentary.In this study, we combine expressional, genetic, and molecular studies to identify two homologousSQUAMOSA PROMOTER BINDING PROTEIN‐LIKE(SPL) transcription factorsZmSPL13andZmSPL29as positive regulators of juvenile‐to‐adult vegetative transition and floral transition in maize.We show that bothZmSPL13andZmSPL29are preferentially expressed in leaf phloem, vegetative and reproductive meristem. We show that vegetative phase change and flowering time are moderately delayed in theZmspl13andZmspl29single knockout mutants and more significantly delayed in theZmspl13/29double mutants. Consistently, theZmSPL29overexpression plants display precocious vegetative phase transition and floral transition, thus early flowering. We demonstrate thatZmSPL13andZmSPL29directly upregulate the expression ofZmMIR172CandZCN8in the leaf, and ofZMM3andZMM4in the shoot apical meristem, to induce juvenile‐to‐adult vegetative transition and floral transition.These findings establish a consecutive signaling cascade of the maize aging pathway by linking the miR156‐SPL and the miR172‐Gl15 regulatory modules and provide new targets for genetic improvement of flowering time in maize cultivars.
Root relative water content is a potential signal for impending mortality of a subtropical conifer during extreme drought stress
Authors: Duan Honglang , Shao Changchang , Luo Xianying , Resco de Dios Víctor , Tissue David T. , Ding Guijie 
Published: June 2023

AbstractAdaptation to future climates characterized by more frequent severe droughts requires enhanced mechanistic understanding of tree mortality. However, our knowledge of the physiological limits to withstand extreme drought, and how the coordination between water and carbon traits enhances survival, is still limited. Potted seedlings of Pinus massoniana were dehydrated to three target droughts (percentage loss of stem hydraulic conductivity of ca. 50%, 85%, and 100%; PLC50, PLC85 and PLC100) and then relieved from these target droughts by fully rewatering. Predawn and midday water potentials (Ψ), relative water content (RWC), PLC and nonstructural carbohydrates (NSC) were monitored. During drought, Ψ and RWC declined as PLC increased. Root RWC declined more rapidly than other organ RWCs, particularly after PLC50 stress. All organ NSC concentrations were above predrought values. During rewatering, water trait recovery declined as drought increased, with no mortality at PLC50 but 75% mortality at PLC85. The observed stem hydraulic recovery at PLC50 following rewatering was not correlated to NSC dynamics. Collectively, our results highlighted the primary role of hydraulic failure in Pinus massoniana seedling mortality by assessing mortality threshold and links among water status and water supply. Root RWC can be considered as a potential warning signal of P. massoniana mortality.