bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concept and study protocol of the process evaluation of a pragmatic randomized controlled trial to promote physical activity in outpatients with heterogeneous mental disorders—the ImPuls study
Authors: Fiedler David Victor , Rosenstiel Stephanie , Zeibig Johanna-Marie , Seiffer Britta , Welkerling Jana , Frei Anna Katharina , Studnitz Thomas , Baur Julia , Helmhold Florian , Ray Andreas , Herzog Eva , Takano Keisuke , Nakagawa Tristan , Kropp Saskia , Franke Sebastian , Peters Stefan , Flagmeier Anna Lena , Zwanzleitner Lena , Sundmacher Leonie , Ramos-Murguialday Ander , Hautzinger Martin , Ehring Thomas , Sudeck Gorden , Wolf Sebastian 
Published: May 2023

Abstract
Background
Evidence suggests that patients suffering from different mental disorders benefit from exercise programs combined with behavior change techniques. Based on this evidence, we have developed an exercise program (ImPuls) specifically designed to provide an additional treatment option in the outpatient mental health care system. The implementation of such complex programs into the outpatient context requires research that goes beyond the evaluation of effectiveness, and includes process evaluation. So far, process evaluation related to exercise interventions has rarely been conducted. As part of a current pragmatic randomized controlled trial evaluating ImPuls treatment effects, we are therefore carrying out comprehensive process evaluation according to the Medical Research Council (MRC) framework. The central aim of our process evaluation is to support the findings of the ongoing randomized controlled trial.

Methods
The process evaluation follows a mixed-methods approach. We collect quantitative data via online-questionnaires from patients, exercise therapists, referring healthcare professionals and managers of outpatient rehabilitative and medical care facilities before, during, and after the intervention. In addition, documentation data as well as data from the ImPuls smartphone application are collected. Quantitative data is complemented by qualitative interviews with exercise therapists as well as a focus-group interview with managers. Treatment fidelity will be assessed through the rating of video-recorded sessions. Quantitative data analysis includes descriptive as well as mediation and moderation analyses. Qualitative data will be analyzed via qualitative content analysis.

Discussion
The results of our process evaluation will complement the evaluation of effectiveness and cost-effectiveness and will, for example, provide important information about mechanisms of impact, structural prerequisites, or provider qualification that may support the decision-making process of health policy stakeholders. It might contribute to paving the way for exercise programs like ImPuls to be made successively available for patients with heterogeneous mental disorders in the German outpatient mental health care system.

Trial registration
The parent clinical study was registered in the German Clinical Trials Register (ID: DRKS00024152, registered 05/02/2021, https://drks.de/search/en/trial/DRKS00024152).
The mental wellbeing of female prisoners in Chile
Authors: Aboaja Anne , Blackwood Douglas , Alvarado Rubén , Grant Liz 
Published: May 2023

Abstract
Objective
To measure and understand mental wellbeing among women prisoners in Chile, as part of a larger study.

Result
Sixty-eight sentenced prisoners in a women’s prison participated in a survey, giving a response rate of 56.7%. Using the Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS), the mean wellbeing score of participants was 53.77 out of maximum score of 70. Whilst 90% of the 68 women felt useful at least some of the time, 25% rarely felt relaxed, close to others or able to make up their own minds about things. Data generated from two focus groups attended by six women offered explanations for survey findings. Thematic analysis identified stress and loss of autonomy due to the prison regime as factors which negatively affect mental wellbeing. Interestingly, whilst offering prisoners an opportunity to feel useful, work was identified as a source of stress. Interpersonal factors linked to a lack of safe friendships within the prison and little contact with family had an adverse impact on mental wellbeing. The routine measurement of mental wellbeing among prisoners using the WEMWBS is recommended in Chile and other Latin American countries to identify the impact of policies, regimes, healthcare systems and programmes on mental health and wellbeing.
COVID-19 pandemic policing and public (non)compliant behaviour: dataset from Nigeria
Authors: Shodunke Aliu Oladimeji , Oladipupo Sodiq Abiodun , Adeoti Sheriffdeen Olasunkanmi , Abidemi Olorede Abdulgafar , Alowolodu Adebusayo Joel , Seriki Oriyomi Oluwasegun , Habeeb Akindele Ayobami , Folorunsho Isiaka Adam , Adebayo Glory David , Faith Mbanefo Onyinye 
Published: May 2023

Abstract
Objectives
The unprecedented nature of COVID-19 pandemic lockdown order projected to contain the pandemic and the global use of the police to enforce the order has necessitated the investigation of public (non-compliant) behavior and police intervention (misconduct). Given that the phases of easing the lockdown and reopening of the economy were already underway in Nigeria in September 2020, four months post-lockdown, this period was deemed suitable to collect the data.

Data description
The data consists of 30 participants’ (25 individuals and five police personnel) views regarding the reasons that exacerbated the violation and the ‘alleged’ unethical practices of police personnel while enforcing the lockdown. However, it benefits the broader scientific community in areas such as policing, disaster risk reduction, pandemic management and public administration. It is valuable in police reforms against unethical practices and gives clear policy directions to policymakers and authorities in managing future public health emergencies. Also, it is useful in understanding the public awareness about the pandemic and public (mis)trust and disposition towards the government authorities on the obedience to law and public health safety advisories to contain a pandemic.
Understanding the relationship between cerebellar structure and social abilities
Authors: Elandaloussi Yannis , Floris Dorothea L. , Coupé Pierrick , Duchesnay Edouard , Mihailov Angeline , Grigis Antoine , Bègue Indrit , Victor Julie , Frouin Vincent , Leboyer Marion , Houenou Josselin , Laidi Charles 
Published: May 2023

Abstract
Background
The cerebellum contains more than 50% of all neurons in the brain and is involved in a broad range of cognitive functions, including social communication and social cognition. Inconsistent atypicalities in the cerebellum have been reported in individuals with autism compared to controls suggesting the limits of categorical case control comparisons. Alternatively, investigating how clinical dimensions are related to neuroanatomical features, in line with the Research Domain Criteria approach, might be more relevant. We hypothesized that the volume of the “cognitive” lobules of the cerebellum would be associated with social difficulties.

Methods
We analyzed structural MRI data from a large pediatric and transdiagnostic sample (Healthy Brain Network). We performed cerebellar parcellation with a well-validated automated segmentation pipeline (CERES). We studied how social communication abilities—assessed with the social component of the Social Responsiveness Scale (SRS)—were associated with the cerebellar structure, using linear mixed models and canonical correlation analysis.

Results
In 850 children and teenagers (mean age 10.8 ± 3 years; range 5–18 years), we found a significant association between the cerebellum, IQ and social communication performance in our canonical correlation model.

Limitations
Cerebellar parcellation relies on anatomical boundaries, which does not overlap with functional anatomy. The SRS was originally designed to identify social impairments associated with autism spectrum disorders.

Conclusion
Our results unravel a complex relationship between cerebellar structure, social performance and IQ and provide support for the involvement of the cerebellum in social and cognitive processes.
Imaging of hepatocellular carcinoma recurrence after liver transplantation
Authors: Mamone Giuseppe , Caruso Settimo , Milazzo Mariapina , Porrello Giorgia , Di Piazza Ambra , Gentile Giovanni , Carollo Vincenzo , Crinò Francesca , Marrone Gianluca , Sparacia Gianvincenzo , Maruzzelli Luigi , Miraglia Roberto , Gruttadauria Salvatore 
Published: May 2023

Abstract
Liver transplantation (LT) provides the highest survival benefit to patients with unresectable hepatocellular carcinoma (HCC). The Milan criteria have been developed for the selection of LT candidates with the goal of improving survival and maintaining an acceptable risk of HCC recurrence. Despite this, recurrence of HCC after LT occurs in up to 20% of cases and represents a major concern due to the poor prognosis of these patients. Furthermore, several extended criteria for the selection of LT candidates have been proposed to account for the growing demand for organs and the resultant increase in the risk of HCC recurrence. Radiologists should be aware that HCC can recur after LT with multiple organ involvement. Knowledge of the location and radiologic appearance of recurrent HCC is necessary to ensure the choice of the most appropriate therapy. This paper aims to comprehensively summarize the spectrum of HCC recurrence after LT and to examine and discuss the imaging features of these lesions.

Graphical Abstract

Critical relevance statement
This paper aims to share a review of imaging findings of HCC recurrence after LT and to make radiologists familiar with the spectrum of this disease.
Has the quality of reporting improved since it became mandatory to use the Standards for Reporting Diagnostic Accuracy?
Authors: Stahl Ann-Christine , Tietz Anne-Sophie , Dewey Marc , Kendziora Benjamin 
Published: May 2023

Abstract
Objectives
To investigate whether making the Standards for Reporting Diagnostic Accuracy (STARD) mandatory by the leading journal ‘Radiology’ in 2016 improved the quality of reporting of diagnostic accuracy studies.

Methods
A validated search term was used to identify diagnostic accuracy studies published in Radiology in 2015 and 2019. STARD adherence was assessed by two independent reviewers. Each item was scored as yes (1 point) if adequately reported or as no (0 points) if not. The total STARD score per article was calculated. Wilcoxon–Mann–Whitney tests were used to evaluate differences of the total STARD scores between 2015 and 2019. In addition, the total STARD score was compared between studies stratified by study design, citation rate, and data collection.

Results
The median number of reported STARD items for the total of 66 diagnostic accuracy studies from 2015 to 2019 was 18.5 (interquartile range [IQR] 17.5–20.0) of 29. Adherence to the STARD checklist significantly improved the STARD score from a median of 18.0 (IQR 15.5–19.5) in 2015 to a median of 19.5 (IQR 18.5–21.5) in 2019 (p < 0.001). No significant differences were found between studies stratified by mode of data collection (prospective vs. retrospective studies, p = 0.68), study design (cohort vs. case–control studies, p = 0.81), and citation rate (two groups divided by median split [< 0.56 citations/month vs. ≥ 0.56 citations/month], p = 0.54).

Conclusions
Making use of the STARD checklist mandatory significantly increased the adherence with reporting standards for diagnostic accuracy studies and should be considered by editors and publishers for widespread implementation.

Critical relevance statement
Editors may consider making reporting guidelines mandatory to improve the scientific quality.

Graphical Abstract
Establishing extended pluripotent stem cells from human urine cells
Authors: Hao Chunfang , Chu Shilong , Quan Xiongzhi , Zhou Tiancheng , Shi Junjie , Huang Xiaofen , Wu Guangming , Tortorella Micky Daniel , Pei Duanqing 
Published: May 2023

Abstract
Background
Extended pluripotent stem cells (EPSCs) can contribute to both embryonic and trophectoderm-derived extraembryonic tissues. Therefore, EPSCs have great application significance for both research and industry. However, generating EPSCs from human somatic cells remains inefficient and cumbersome.

Results
In this study, we established a novel and robust EPSCs culture medium OCM175 with defined and optimized ingredients. Our OCM175 medium contains optimized concentration of L-selenium-methylcysteine as a source of selenium and ROCK inhibitors to maintain the single cell passaging ability of pluripotent stem cells. We also used Matrigel or the combination of laminin 511 and laminin 521(1:1) to bypass the requirement of feeder cells. With OCM175 medium, we successfully converted integration-free iPSCs from easily available human Urine-Derived Cells (hUC-iPSCs) into EPSCs (O-IPSCs). We showed that our O-IPSCs have the ability to form both intra- and extra- embryonic chimerism, and could contribute to the trophoblast ectoderm lineage and three germ layer cell lineages.

Conclusions
In conclusion, our novel OCM175 culture medium has defined, optimized ingredients, which enables efficient generation of EPSCs in a feeder free manner. With the robust chimeric and differentiation potential, we believe that this system provides a solid basis to improve the application of EPSCs in regenerative medicine.
Intelligent resource allocation scheme for cloud-edge-end framework aided multi-source data stream
Authors: Wu Yuxin , Cai Changjun , Bi Xuanming , Xia Junjuan , Gao Chongzhi , Tang Yajuan , Lai Shiwei 
Published: May 2023

AbstractTo support multi-source data stream generated from Internet of Things devices, edge computing emerges as a promising computing pattern with low latency and high bandwidth compared to cloud computing. To enhance the performance of edge computing within limited communication and computation resources, we study a cloud-edge-end computing architecture, where one cloud server and multiple computational access points can collaboratively process the compute-intensive data streams that come from multiple sources. Moreover, a multi-source environment is considered, in which the wireless channel and the characteristic of the data stream are time-varying. To adapt to the dynamic network environment, we first formulate the optimization problem as a markov decision process and then decompose it into a data stream offloading ratio assignment sub-problem and a resource allocation sub-problem. Meanwhile, in order to reduce the action space, we further design a novel approach that combines the proximal policy optimization (PPO) scheme with convex optimization, where the PPO is used for the data stream offloading assignment, while the convex optimization is employed for the resource allocation. The simulated outcomes in this work can help the development of the application of the multi-source data stream.
Loss-of-function mutations in MYO15A and OTOF cause non-syndromic hearing loss in two Yemeni families
Authors: Asaad Maria , Mahfood Mona , Al Mutery Abdullah , Tlili Abdelaziz 
Published: May 2023

Abstract
Background
Hearing loss is a rare hereditary deficit that is rather common among consanguineous populations. Autosomal recessive non-syndromic hearing loss is the predominant form of hearing loss worldwide. Although prevalent, hearing loss is extremely heterogeneous and poses a pitfall in terms of diagnosis and screening. Using next-generation sequencing has enabled a rapid increase in the identification rate of genes and variants in heterogeneous conditions, including hearing loss. We aimed to identify the causative variants in two consanguineous Yemeni families affected with hearing loss using targeted next-generation sequencing (clinical exome sequencing). The proband of each family was presented with sensorineural hearing loss as indicated by pure-tone audiometry results.

Results
We explored variants obtained from both families, and our analyses collectively revealed the presence and segregation of two novel loss-of-function variants: a frameshift variant, c.6347delA in MYO15A in Family I, and a splice site variant, c.5292-2A > C, in OTOF in Family II. Sanger sequencing and PCR–RFLP of DNA samples from 130 deaf and 50 control individuals confirmed that neither variant was present in our in-house database. In silico analyses predicted that each variant has a pathogenic effect on the corresponding protein.

Conclusions
We describe two novel loss-of-function variants in MYO15A and OTOF that cause autosomal recessive non-syndromic hearing loss in Yemeni families. Our findings are consistent with previously reported pathogenic variants in the MYO15A and OTOF genes in Middle Eastern individuals and suggest their implication in hearing loss.
The economic impact of eating disorders in children and youth in Canada: a call to action to improve youth eating disorder research and care
Authors: Coelho Jennifer S. , Booij Linda , Katzman Debra K. , Dimitropoulos Gina , Obeid Nicole 
Published: May 2023

AbstractThe COVID-19 pandemic has led to an unprecedented rise in rates and symptoms of eating disorders among Canadian youth. To date, there is a lack of national surveillance and costing data in Canada to inform policymakers and healthcare leaders on how to best address the surge in new and existing cases. This has resulted in the Canadian healthcare system being unprepared to adequately respond to the increased needs. Therefore, clinicians, researchers, policymakers, decision-makers, and community organizations across Canada are collaborating to compare pre-and post-pandemic costing data from national and province-level healthcare systems in an effort to address this gap. Results from this economic cost analysis will be an important first step in informing and guiding policy on possible adaptations to services to better fulfill the needs of youth with eating disorders in Canada. We highlight how gaps in surveillance and costing data can impact the field of eating disorders in an international context.
A comparison of machine learning methods for ozone pollution prediction
Authors: Pan Qilong , Harrou Fouzi , Sun Ying 
Published: May 2023

AbstractPrecise and efficient ozone ($$\hbox {O}_{3}$$O3) concentration prediction is crucial for weather monitoring and environmental policymaking due to the harmful effects of high$$\hbox {O}_{3}$$O3pollution levels on human health and ecosystems. However, the complexity of$$\hbox {O}_{3}$$O3formation mechanisms in the troposphere presents a significant challenge in modeling$$\hbox {O}_{3}$$O3accurately and quickly, especially in the absence of a process model. Data-driven machine-learning techniques have demonstrated promising performance in modeling air pollution, mainly when a process model is unavailable. This study evaluates the predictive performance of nineteen machine learning models for ozone pollution prediction. Specifically, we assess how incorporating features using Random Forest affects$$\hbox {O}_{3}$$O3concentration prediction and investigate using time-lagged measurements to improve prediction accuracy. Air pollution and meteorological data collected at King Abdullah University of Science and Technology are used. Results show that dynamic models using time-lagged data outperform static and reduced machine learning models. Incorporating time-lagged data improves the accuracy of machine learning models by 300% and 200%, respectively, compared to static and reduced models, under RMSE metrics. And importantly, the best dynamic model with time-lagged information only requires 0.01 s, indicating its practical use. The Diebold-Mariano Test, a statistical test used to compare the forecasting accuracy of models, is also conducted.
Rupture processes of the 2021 and 2022 Fukushima-oki earthquakes: adjacent events on the complex fault system in the subducting slab
Authors: Kobayashi Hiroaki , Watanabe Tetsushi , Koketsu Kazuki 
Published: May 2023

AbstractThe 2021 Mw 7.1 and 2022 Mw 7.4 Fukushima-oki earthquakes ruptured adjacent regions in the subducting slab, which gave us a good opportunity to better understand the rupture process of an intraslab earthquake and the fault system in a subducting slab hosting such large earthquakes. We developed source models of the two earthquakes by constructing fault models based on the distributions of relocated aftershocks and performing joint source inversion using strong motion, teleseismic and geodetic data. The results showed that the 2021 earthquake was initiated by the west-northwest dipping fault and that it then ruptured the east-southeast dipping fault. The rupture propagated to the southwest and up-dip directions. For the 2022 earthquake, the rupture primarily propagated to the north-northeast and up-dip directions on another east-southeast dipping fault, but a delayed rupture occurred around the hypocenter approximately 12 s after the rupture initiation. This was probably due to the complex fault system around the hypocenter. Our source models accurately reproduced observed data for both earthquakes, indicating that the fault geometry was appropriate. We found that the source faults of these earthquakes had similarities to faults in the outer-rise region, which suggests that the 2021 and 2022 earthquakes occurred on faults that originally formed in the outer-rise region and reactivated in the subducting slab. Such a fault system in the subducting slab was probably one of the factors that controlled the rupture processes of the two earthquakes.
Graphical Abstract
An experimental porcine model of invasive candidiasis
Authors: Krifors Anders , Lignell Anders , Lipcsey Miklós , Sjölin Jan , Castegren Markus 
Published: May 2023

Abstract
Background
Invasive candidiasis (IC) is a severe and often fatal fungal infection that affects critically ill patients. The development of animal models that mimic human disease is essential for advancing our understanding of IC pathophysiology and testing experimental or novel treatments. We aimed to develop a large animal model of IC that could provide a much-needed addition to the widely used murine models.

Results
A total of 25 pigs (including one control), aged between 9 and 12 weeks, with a median weight of 25.1 kg (IQR 24.1–26.2), were used to develop the porcine IC model. We present the setup, the results of the experiments, and the justification for the changes made to the model. The experiments were conducted in an intensive care setting, using clinically relevant anaesthesia, monitoring and interventions. The final model used corticosteroids, repeated Candida inoculation, and continuous endotoxin. The model consistently demonstrated quantifiable growth of Candida in blood and organs. The registered physiological data supported the development of the sepsis-induced circulatory distress observed in IC patients in the ICU.

Conclusions
Our proposed porcine model of IC offers a potential new tool in the research of IC.
Globalizing the sociology of the arts and culture: East Asian perspectives
Authors: Fang Jun 
Published: May 2023

AbstractIn this editorial, I argue for a globalized sociology of the arts and culture that transcends West-centered theories and practices. To this end, two interrelated perspectives—global and decentering—are needed. The article commences with a brief overview of the emergence of the sociology of arts in the West, and synthesizes major themes emerging from articles in the thematic series and the existing literature on creative cultures in East Asia. These themes include local–global dynamics (such as flows, legitimacy, and the centrality of the local), regionalization, state support and control, and theorizing beyond the arts. Finally, I highlight several promising directions for future research, and emphasize that East Asian perspectives present distinct opportunities to advance the sociology of the arts and culture.