bluuebunny/crossref_metadata_2025_split huggingface dataset:
The severity of coronary heart disease and the incidence of later diabetic retinopathy in diabetic population: A retrospective cohort study
Authors: Ting Ke-Hsin , Yang Po-Jen , Huang Jing-Yang , Lee Chia-Yi , Su Shih-Chi , Yang Shun-Fa 
Published: January 2025

Objectives
The coronary heart disease (CHD) can influence the development of several diseases. The presence of CHD is correlated to a higher incidence of concurrent diabetic retinopathy (DR) in previous study. Herein, we aim to analyze the relationship between the CHD severity and following DR with different severity.

Methods
A retrospective cohort study was conducted with the usage of Taiwan National Health Insurance Research Database (NHIRD). The CHD patients with DM were categorized into those with medical treatments and those received percutaneous coronary intervention (PCI) management with a 1:1 ratio. The major outcome was the development of DR, diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) 6 months after the onset of CHD.

Results
There was 7317, 316, and 386 episodes of DR, DME and PDR in the mild CHD groups and 8568, 411, and 508 events of DR, DME and PDR in the severe CHD groups, respectively. The severe CHD group showed a significantly higher incidence of DR (aHR: 1.063, 95% CI: 1.038–1.089, P = 0.0324), DME (aHR: 1.412, 95% CI: 1.252–1.594, P = 0.0092) and PDR (aHR: 1.314, 95% CI: 1.172–1.473, P = 0.0113) compared to the mild CHD group. The cumulative incidence of DR was significantly higher in the severe CHD group (P < 0.001). In the subgroup analysis, the association between CHD severity and DR was more prominent in the female population (P = 0.0224).

Conclusions
The severe CHD is associated with higher incidence of following DR, DME and PDR, while the incidence of DR in CHD is positively correlated to longer disease period.
Effectiveness of couple-based violence prevention education in reducing intimate partner violence during pregnancy in rural Ethiopia: A cluster randomized controlled trial
Authors: Agde Zeleke Dutamo , Magnus Jeanette H. , Assefa Nega , Wordofa Muluemebet Abera 
Published: January 2025

Background
Pregnancy is often seen as a joyful and fulfilling time for many women. However, a significant number of women in Ethiopia experience intimate partner violence (IPV) during this period. Despite this, there is limited evidence on interventions aimed at preventing violence during pregnancy. The purpose of this trial was to examine the effectiveness of Couple-Based Violence Prevention Education (CBVPE) in reducing IPV during pregnancy in rural Ethiopia.

Method
A cluster randomized controlled trial was conducted using a two-arm parallel group design. The 16 clusters were randomly allocated into 8 intervention groups and 8 control groups. A total of 432 pregnant women (216 in the intervention group and 216 in the control group) participated in the trial. Couple-based violence prevention education was provided to the participants in the intervention group, while the control group received routine or standard care. We used difference-in-difference analysis and the Generalized Estimating Equation (GEE) model to assess the effectiveness of the intervention.

Result
At the endline, 94.9% of women in the intervention group and 95.3% of women in the control group were available for intention-to-treat analysis. There was a substantial drop in the proportion of any IPV during pregnancy from 39.4% at baseline to 13.0% at endline (p<0.001). Women in the intervention group were 74.1% less likely to report any IPV during pregnancy compared to the control group (AOR = 0.259; 95% CI 0.161–0.417). Specifically, the intervention also reduced psychological, physical, and sexual violence during pregnancy.

Conclusion
The study found that CBVPE is effective in reducing IPV during pregnancy in the study setting. Scale-up and adaptation to similar settings are recommended.

Trial registration
The trial is registered on ClinicalTrials.gov under the identifier NCT05856214 on May 4, 2023.
The effects of lowering barometric pressure on pain behavior and the stress hormone in mice with neuropathic pain
Authors: Terajima Yuki , Sato Jun , Inagaki Hideaki , Ushida Takahiro 
Published: January 2025

Background
Lowering barometric pressure (LP) can exacerbate neuropathic pain. However, animal studies in this field are limited to a few conditions. Furthermore, although sympathetic involvement has been reported as a possible mechanism, whether the sympathetic nervous system is involved in the hypothalamic-pituitary-adrenal (HPA) axis remains unknown. To address these issues, we investigated LP-induced hyperalgesia by focusing on the cumulative effect of LP and measuring plasma corticosterone levels as a marker of HPA axis activation in mice.

Methods
Mice with chronic constriction injury (CCI) were used in this study. For behavioral tests, two types of LP stimulation were adopted: a single LP at 20 hPa (Single LP) and three consecutive LPs at 20 hPa (3LPs). Twelve mice were used for each protocol. The no-pressure-change protocol was used as the control. The mechanical sensitivity was tested before and after LP stimulation using von Frey filaments (vF). For corticosterone measurements, six CCI and six intact mice were exposed to 3LPs (CCI-3LPs and INT-3LPs), and another six CCI and six intact mice were exposed to the no-pressure-change protocol (CCI-NP and INT-NP). Blood samples were collected immediately after exposure. Plasma corticosterone levels were measured by ELISA.

Results
The number of paw elevations by vF before and after LP stimulation did not differ significantly in either the Single LP or the no-pressure-change protocol. For the 3LPs, the number of paw elevations after LP stimulation was significantly greater than before stimulation. Plasma corticosterone levels in the CCI-3LPs were significantly higher than those in CCI-NPs. In intact mice, there was no significant difference in plasma corticosterone levels between the INT-3LPs and INT-NPs.

Conclusions
LP has a cumulative effect on neuropathic pain. Hypothalamic-pituitary-adrenal axis activation may have an important relationship with LP-induced pain in mice.
Higher Relapse Rate in HBeAg-Negative Patients After Cessation of Tenofovir Alafenamide Compared With Entecavir or Tenofovir Disoproxil Fumarate
Authors: Fang Hsin-Wei , Jeng Wen-Juei , Hu Tsung-Hui , Wang Jing-Houng , Hung Chao-Hung , Lu Sheng-Nan , Chen Chien-Hung 
Published: January 2025

INTRODUCTION:
There is limited information comparing the off-therapy relapse rates of patients discontinued tenofovir alafenamide (TAF) to those stopping entecavir or tenofovir disoproxil fumarate (TDF).

METHODS:
A total of 805 hepatitis B e antigen-negative patients without cirrhosis receiving entecavir (n = 406), TDF (n = 260), or TAF (n = 139) were enrolled. Propensity score matching method was applied to eliminate the significant differences in clinical characteristics.

RESULTS:
The cumulative incidences of virological relapse, clinical relapse, and retreatment at 96 weeks were higher in the off-TAF group (89.6%, 70.3%, and 59.2%, respectively) than that in the off-entecavir group (65.9%, 42.8%, and 28.8%, respectively) or the off-TDF group (73.7%, 49.8%, and 35.7%, respectively). The median time to clinical relapse was much earlier for off-TAF patients than for off-entecavir or off-TDF (median 14, 57, and 26 weeks, respectively), and these findings persisted even after propensity score matching. Multivariate analysis indicated that TAF therapy was an independent risk factor of virological relapse, clinical relapse, and retreatment when compared with entecavir or TDF. Hepatitis B surface antigen levels at end of treatment were predictive of virological, but not clinical, relapse in the off-TAF group, although this group had a lower rate of severe hepatitis on clinical relapse than the off-TDF group. Finally, there was no significant difference in the hepatic decompensation rate among the entecavir, TDF, and TAF groups.

DISCUSSION:
There is an earlier and higher hepatitis B virus relapse rate in patients who discontinue TAF therapy than in comparable patients discontinuing entecavir or TDF therapy. Close monitoring is necessary after TAF withdrawal, particularly in the first 3 months.
Trudinger–Moser type inequalities with logarithmic weights in fractional dimensions
Authors: Xue Jianwei , Zhang Caifeng , Zhu Maochun 
Published: January 2025

Abstract
The purpose of this paper is two-fold. First, we derive sharp Trudinger–Moser inequalities with logarithmic weights in fractional dimensions:

sup

∫

0

1

w

(

r

)

u

′

(

r

)

β
+
2

d

λ

α

1
/

(

β
+
2

)

≤
1

∫

0

1

e

μ

α
,
θ
,
γ

u

β
+
2

β
+
1

1
−
γ

d

λ

θ

<
+
∞
,

$$\,\underset{{\left(\underset{0}{\overset{1}{\int }}w\left(r\right){\left\vert {u}^{\prime }\left(r\right)\right\vert }^{\beta +2}\mathrm{d}{\lambda }_{\alpha }\right)}^{1/\left(\beta +2\right)}\le 1}{\mathrm{sup}}\underset{0}{\overset{1}{\int }}{\text{e}}^{{\mu }_{\alpha ,\theta ,\gamma }{\left\vert u\right\vert }^{\frac{\beta +2}{\left(\beta +1\right)\left(1-\gamma \right)}}}\mathrm{d}{\lambda }_{\theta }{< }+\infty ,$$

where 0 ≤ γ < 1, α = β + 1,

μ

α
,
θ
,
γ

≔

θ
+
1

ω

α

1
/
α

1
−
γ

1

1
−
γ

${\mu }_{\alpha ,\theta ,\gamma }{:=}\left(\theta +1\right){\left[{\omega }_{\alpha }^{1/\alpha }\left(1-\gamma \right)\right]}^{\frac{1}{1-\gamma }}$

,

w

(

r

)

=

w

1

(

r

)

=

log

1

r

γ

β
+
1

$w\left(r\right)={w}_{1}\left(r\right)={\left(\mathrm{log}\frac{1}{r}\right)}^{\gamma \left(\beta +1\right)}$

or

w

(

r

)

=

w

2

(

r

)

=

log

e

r

γ

β
+
1

$w\left(r\right)={w}_{2}\left(r\right)={\left(\mathrm{log}\frac{e}{r}\right)}^{\gamma \left(\beta +1\right)}$

and λ

θ
(E) = ω

θ

∫

E

r

θ
dr for all

E
⊂
R

$E\subset \mathbb{R}$

. The case γ > 1 and γ = 1 are also be considered in this part to improve our paper. Indeed, we have a continuous embedding X(w
2) ↪ L
∞(0, 1) for γ > 1 and a critical growth of double exponential type for γ = 1. Second, we apply the Lions type Concentration-Compactness principle for Trudinger–Moser inequalities and the precise estimate of normalized concentration limit for normalized concentrating sequence at origin to establish the existence of extremals for Trudinger–Moser inequalities when

w

(

r

)

=

w

1

(

r

)

=

log

1

r

γ

β
+
1

$w\left(r\right)={w}_{1}\left(r\right)={\left(\mathrm{log}\frac{1}{r}\right)}^{\gamma \left(\beta +1\right)}$

and γ > 0 is sufficiently small.
Extraction and characterization of natural fibre from Ethiopian Typha latifolia leaf plant
Authors: Admas Anmen , Assefa Alemayehu 
Published: January 2025

Abstract
The environmental issues associated with synthetic fibres have led to a significant growth in the use of natural fibres (NFs). Because of this environmental issue, the demand for NF is higher as compared to synthetic fibres. The purpose of the present study was to extract and characterize fibres from the Ethiopian Typha latifolia leaf plant. Manual, water-retting, and chemical extraction techniques were employed for the extraction of the fibre from the leaf of the Typha latifolia plant. The extracted fibre’s chemical content was evaluated, and its cellulose, hemicellulose, and lignin contents were almost similar to those of other NFs. The mean length, fineness, and tensile strength of fibre extracted by manual, water retting, and alkaline methods were determined, and its length was 502, 489, and 389 mm, and its fineness was 1.42 ± 0.4 Tex, 1.32 ± 0.2 Tex, and 1.12 ± 0.15 Tex, and its strength was 260.3, 308.5, and 192.8 MPa, respectively. The ranges for moisture content and regain were 8.4–10.8% and 8.7–11.4%, respectively, which is comparable to other natural plant fibres (5–17%). The Fourier transform-infrared curves of the extracted fibre revealed the presence of the functional groups for cellulose, hemicellulose, and lignin.
Priced Out: Do Adolescents from Low-Income Families Respond More to Cost-Sharing in Primary Care?
Authors: Haaga Tapio , Böckerman Petri , Kortelainen Mika , Tukiainen Janne 
Published: January 2025

Abstract
We examine the heterogeneous effects of 14–21 euro copayments on primary care general practitioners (GPs) visits in Finland. Our study focuses on a triage-based appointment system in public primary care. Using an age-based regression discontinuity (RD) design and leveraging variation across Finnish municipalities in whether the copayment is charged, we analyze the effects at the 18th birthday, when previously exempted adolescents become subject to copayments. Using nationwide administrative data from 2011 to 2019, we find that GP visits decrease in the copayment municipalities by 4–5 %. The reductions are largest for the bottom 20 % of the equivalized family disposable income distribution: their GP use decreases by 0.08–0.10 annualized visits (7–10 %). Unexpectedly, the effects are also larger than average (albeit rather temporary) for the top 50 %, showing reductions of 6–8 %. Compared to earlier studies focusing on moderate copayments and different populations, our effect estimates are smaller, and the heterogeneity by income level is weaker.
Non-native and spreading craneflies in Europe: A review, with first and additional records
Authors: Kolcsár Levente-Péter 
Published: January 2025

AbstractDespite the more than 15.700 known cranefly species, only a few species have been identified or hypothesized as non-native species. However, in recent years, reports of non-native craneflies in Europe have increased significantly. This work provides a comprehensive list of species either confirmed or suspected to be non-native in Europe, as well as native species that have recently appeared in new countries and are expanding their distribution ranges. Additionally, Atypophthalmus umbratus (de Meijere, 1911) has been reported for the first time in Denmark, within greenhouse environments. Gnophomyia tristissima Osten Sacken, 1860 was observed in a natural habitat in Hungary, marking the second European occurrence of this species. Rhipidia (Rhipidia) domestica Osten Sacken, 1860, and Nephrotoma suturalis wulpiana (Bergroth, 1888) were found in Romania, originating from a plant shop. Furthermore, Tipula (Pterelachisus) trifascingulata Theowald, 1980, from Luxembourg, and Nephrotoma quadrifaria quadrifaria (Meigen, 1804), from Northern European Russia, are reported here for the first time. Achyrolimonia neonebulosa (Alexander, 1924), another recently spearing species, was discovered trapped on the leaves of sundews (Drosera spp.) in the same plant shop where R. domestica and N. s. wulpiana were collected in Romania. These findings underscore the likelihood that these species have already become widely dispersed through plant trade across Europe.
UTILIZAÇÃO DE CINZAS E EXTRATOS DE PLANTAS ESPONTÂNEAS NA NUTRIÇÃO MINERAL E PROTEÇÃO VEGETAL PARA O CULTIVO DE BETERRABAS
Authors: Santos Lucas Barbosa dos , Barbosa Flávia Silva , Guerra Antônia Mirian Nogueira de Moura , Andrea Vita Reis Medonça  , Silva Alicia Gonçalves , Aquino Tailande Novaes de 
Published: January 2025

Os desafios tradicionais enfrentados na agricultura incluem a presença de herbívoros, fitopatógenos e plantas espontâneas. No entanto, estudos recentes apontam para uma perspectiva diferente, sugerindo que esses elementos podem indicar problemas no manejo agrícola, mas também oferecem oportunidades. As plantas espontâneas, em particular, têm sido reconhecidas como indicadoras de saúde do solo e podem desempenhar papéis benéficos na agricultura, assim como em setores como o farmacêutico e alimentício. Com o objetivo de explorar o potencial dessas plantas, realizamos um experimento para avaliar a eficácia de cinzas e extratos vegetais como protetores na cultura da Beta vulgaris esculenta. O experimento foi conduzido em casa de vegetação, em delineamento inteiramente casualizado, com oito tratamentos e cinco repetições, totalizando 40 parcelas experimentais. Os tratamentos avaliados foram compostos pela combinação de cinza vegetal, composto de esterco (esterco bovino) e solo na base de volume conhecido, solo como substrato, no qual constituiu a testemunha. A semeadura foi realizada diretamente em vasos do tipo floreiras retangulares (dimensões: 50cm x 17cm x 20cm - 17L), na densidade de 5 mudas/vaso. Os resultados revelaram que certos tratamentos, especialmente aqueles envolvendo cinzas da planta espontânea Sida cordifolia, tiveram impactos significativos no crescimento da parte aérea e na produção de raízes comestíveis da beterraba. Além disso, observou-se um aumento no diâmetro das raízes, indicando características favoráveis para o cultivo. Esses achados sugerem que a utilização de cinzas e extratos de plantas espontâneas pode ser uma estratégia promissora para melhorar várias características da cultura da beterraba, destacando-se a relevância da Sida cordifolia como uma potencial fonte de benefícios agrícolas.
Clinical Characteristics, Treatment Outcomes, And Prognostic Factors of Laryngeal Neuroendocrine Carcinoma: A Population-Based Analysis
Authors: Wang Qingling , Xie Feng , Guo Shiduo , Xu Zhenju , Pang Wenhui , Guo Xiangdong , Jiang Liwei 
Published: January 2025

Abstract

Objective. Laryngeal neuroendocrine carcinoma (LNEC) is a rare and aggressive malignancy with poor prognosis.This study investigates the clinical characteristics, treatments and prognostic factors of LNEC patients. Methods. Data from the Surveillance, Epidemiology, and End Results (SEER) database and the Affiliated Hospital of Qingdao University cohort (2008–2018) were analyzed. Kaplan-Meier and Cox regression models were used to evaluate demographic, treatment, and 5-year disease-specific survival (DSS) data. Results. A total of 125 patients (111 SEER, 14 Qingdao) with a median age of 60 years were included. Most were male and had supraglottic tumors.The five-year DSS was 30.6% (SEER) and 35.7% (Qingdao).Grade III tumors (HR = 3.04, P = 0.003) were associated with worse outcomes, whereas partial laryngectomy (HR = 0.34, P = 0.018) was linked to better survival. Conclusion. Low-grade tumors and partial laryngectomy are associated with better survival. Larger studies are needed to confirm these findings.
An Improved NSGA-II Method for Solving Multi-objective Flexible Job-shop Scheduling Problems
Authors: Jiang Ming , Wei Hanxi , Peng Dongpeng , Chen Shu 
Published: January 2025

Abstract

This paper addresses the multi-objective optimization problem in flexible job-shop scheduling, establishing a model that optimizes completion time, total machine load, and energy consumption. An improved version of the Non-dominated Sorting Genetic Algorithm II (NSGA-II) is proposed. This algorithm is designed with multi-objective optimization in mind, featuring a population initialization method for multiple objective functions that enhance the quality and diversity of the population. It also introduces an adaptive crossover and mutation operator, incorporating evaluation during the crossover and mutation process to raise the quality of the offspring. An experience-based improved elite preservation strategy has been designed to prevent the reduction of population diversity in the later stages of evolution while protecting high-quality individuals from degradation during the genetic process. The results demonstrate that the advantages of this algorithm can more effectively solve the multi-objective flexible job-shop scheduling problem. As a core optimization problem in modern manufacturing, flexible job-shop scheduling aims to maximize production efficiency and cost-effectiveness through the rational allocation of shop resources.
Gait retraining with real-time visual biofeedback reduces pain, plantar loading and increase function in runners with plantar fasciitis: randomized clinical trial
Authors: Pinto Giovanna Truyts Biscardi , Pinto Marcos Antônio Leite Pereira , Souza Júlia Constante , Maia Guilherme Silveira , Esteves André Luiz Cruz , Salomão Ricardo Cesar , Oliveira Gabrielle Souza , Shull Peter B. , Ribeiro Ana Paula 
Published: January 2025

Abstract

Background
Plantar fasciitis (PF) affects approximately 2 million individuals per year, affecting approximately 10–25% of runners around the world. It is considered to have a great impact on health, especially due to the pain and functional limitations of the feet and lower limbs. Thus, the objective of this randomized clinical trial was to verify the effect of gait retraining with real-time visual feedback on pain, function, and biomechanical parameters of plantar loading in runners with and without PF.
Methods
Controlled, randomized clinical trial with blinded evaluators. Participants: 24 runners were evaluated and divided into two groups: 12 runners with plantar fasciitis and 12 control runners. The assessments were performed pre-intervention and post-intervention. The intervention protocol consisted of gait retraining during treadmill running, for 5 consecutive weeks, over two months (2 sessions/week, 40 min/session, total of 10 sessions). Primary outcomes were: feet pain by visual analogue scale and plantar pressure during gait on the pressure platform. Secondary outcomes were: functionality of the feet and lower limbs, evaluated through the questionnaires: Foot Function Index, Foot and Ankle Ability Measure and Lower Extremity Functional Scale, and the Foot Posture Index. Data were analyzed according to intention-to-treat.
Results
Runners with PF presented improvement in pain and physical-functional performance, as well as a reduction in plantar overload on the rearfoot after the intervention protocol when compared to the initial assessment and control, with a moderate to high effect size. In relation to the control group, there were no significant differences after intervention in physical-functional performance, but there was a reduction in the loading rate on the rearfoot.
Conclusion
A ten-week treadmill gait retraining program using real-time visual biofeedback was effective in reducing pain and plantar pressure on the rearfoot, favoring an increase in the functionality of the feet and lower limbs of runners with plantar fasciitis.
Trial registration number: RBR-5m6msq7