bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discussion Regarding the Development of Lake Toba Geopark Tourism and Inter-Regional Cooperation with the Management Agency Toba Caldera UNESCO Global Geopark
Authors: Hutasoit Posma Sariguna Johnson Kennedy , Tobing Suzanna Josephine L , Lumbantoruan Rutman , Mangani Ktut Silvanita , Manullang Ricky Martin 
Published: April 2023

The establishment of the Toba Caldera as a UNESCO Global Geopark provides opportunities for local village communities to promote culture and local products and create wider employment opportunities. The purpose of this community service activity is to gain an understanding of the importance of inter-regional cooperation in the development of the UNESCO Global Geopark Toba Caldera tourist area. This inter-regional cooperation can provide sustainable growth, thereby increasing the welfare of local communities. The activities were carried out by visiting the UNESCO Global Geopark Toba Caldera Management Agency, especially at the Samosir Regency Regional Government Office. The development of the Lake Toba area needs to be carried out jointly with the eight regencies around the Lake Toba area in an integrated and sustainable manner, and it cannot work alone. For example, in procuring and repairing roads as entrances to tourist areas, especially tourist villages in the Lake Toba Region. No region can provide for itself because each region has advantages and disadvantages that can be mutually beneficial through good cooperation.
Keywords: Geopark, Toba Lake, Toba Caldera, Regional Cooperation, North Sumatra
EDUKASI KESEHATAN TENTANG BAHAYA PERGAULAN BEBAS PADA REMAJA DI KELURAHAN CAWANG JAKARTA TIMUR
Authors: Damanik Sri Melfa 
Published: April 2023

Remaja adalah masa peralihan dari kanak-kanak ke dewasa, dan masa yang labil dimana remaja mencari jati diri. Masalah yang terjadi di masa remaja adalah remaja tidak mengetahui bahaya pergaulan bebas yang terdiri dari merokok, menggunakan narkoba dan seks bebas. Tujuan pelaksanaan Pengabdian kepada Masyarakat (PkM) ini yaitu untuk Meningkatkan pengetahuan remaja mengenai bahaya pergaulan bebas. Sebanyak 139 siswa dan siswi beserta guru yang ikut dalam kegiatan PkM. Metode pelaksanaan PkM yaitu melakukan edukasi kesehatan secara online zoom meeting dengan pemberian pretest dan post test kuesioner yang diisi oleh 94 siswa dan 6 guru. Hasil PkM menunjukkan ada peningkatan pengetahuan baik dari 6 responden (6%) menjadi 8 responden (8%). Pengetahuan cukup dari 20 responden (20%) menjadi 74 responden (74%). Pengetahuan kurang dari 74 responden (74%) menjadi hanya 8 (18%) responden. Pemberian edukasi yang dilakukan secara rutin di masyarakat dapat menjadi salah satu solusi yang tepat untuk meningkatkan derajat kesehatan masyarakat dan mengurangi pergaluan bebas pada remaja di Indonesia.
Kata kunci: Bahaya Pergaulan Bebas; Remaja; Merokok; Narkoba; Seks Bebas
Pengetahuan Tentang Perilaku dan Bahaya Seks Bebas Bagi Remaja HKBP Duren Jaya Bekasi
Authors: Siregar Rospita Adelina 
Published: April 2023

Pengetahuan tentang fungsi alat reproduksi yang benar dan pengetahuan adanya sanksi pidana bagi pelaku kejahatan seksual sesuai dengan hukum positif di Indonesia, diharapkan dapat menghindari terjadinya perilaku seks bebas dikalangan remaja. Punyuluhan bertema PENGETAHUAN TENTANG PERILAKU DAN BAHAYA SEKS BEBAS BAGI REMAJA.HKBP DUREN JAYA BEKASI merupakan bagian dari pengabdian kepada masyarakat UKI dengan HKBP Duren Jaya di tahun 2022, sasarannya adalah peserta sidi. Pemberi materi adalah dosen UKI yang memiliki kompetensi keilmuan dibidang pendidikan dan hukum kesehatan, menitik beratkan bahwa perlu adanya penguasaan diri, hasrat biologis yang terkontrol dengan menerapkan kehidupan yang beretika,disiplin dan bertanggungjawab atas organ reproduksinya dapat menghindari terjadinya kejahatan seksual seperti pelecahan seksual, pemerkosaan dan aborsi . Ancaman terjadinya seksual pranikah yang masih banyak terjadi di Indonesia perlu perhatian dari orang tua, dan pihak terkait lainnya. Kehamilan diluar nikah pada usia dini akan menunda keberhasilan untuk meraih cita-cita, penyuluhan bahaya seks bebas perlu dilakukan terus menerus dengan melibatkan keluarga, sekolah pemuka agama, dan organisasi masyarakat.
Kata Kunci: reproduksi , seks bebas, pidana
Comparing fiber quality characteristics and staple length in Suri and Huacaya alpacas
Authors: Pinares Rubén , Meza Aydee , Crispín Neyla , Lozano Franklin , Pezo Danilo 
Published: April 2023

IntroductionThe textile industry considers alpaca fiber to be a specialty fiber. The aim of this study was to evaluate the influence of color, breed, location, age, and sex of alpacas on fiber quality characteristics and staple length.MethodsFiber samples were taken from the mid-side of 118 Huacaya and Suri alpacas at two livestock shows (Pitumarca and Maranganí) and at CICAS La Raya (South American Camelid Research Center), which is located in the province of Canchis (Cusco, Peru).Results and discussionThe fiber characteristics and staple length in black alpacas are similar to those of brown alpacas. Huacaya fiber is finer, having a lower mean fiber diameter (MFD), SD, and coefficient of variation of MFD than Suri fiber. Alpacas from the two livestock shows have higher-quality fiber than unselected alpacas raised in CICAS La Raya. Staple length is longer in Suri alpacas than in Huacaya alpacas. Likewise, the staple length is longer in alpacas from Pitumarca, followed by alpacas from Maranganí, and is shorter in alpacas from CICAS La Raya. Young alpacas have a shorter staple length than adults, and it is longer in females than in males. The mean fiber diameter and spinning fineness are strongly correlated with other fiber characteristics in colored alpacas.ConclusionThese black and brown alpacas raised in small herds and judged in two livestock shows produce high-quality fiber at 22 µm for the textile industry.
Comparison of effective regurgitant orifice area by the PISA method and tricuspid coaptation gap measurement to identify very severe tricuspid regurgitation and stratify mortality risk
Authors: Bohbot Yohann , Tordjman Léa , Dreyfus Julien , Le Tourneau Thierry , Lavie-Badie Yoan , Selton-Suty Christine , Elegamandji Benjamin , L’official Guillaume , Fraix Antoine , Aghezzaf Samy , Turgeon Pierre Yves , Messika Zeitoun David , Enriquez-Sarano Maurice , Coisne Augustin , Donal Erwan , Tribouilloy Christophe 
Published: April 2023

IntroductionVarious definitions of very severe (VS) tricuspid regurgitation (TR) have been proposed based on the effective regurgitant orifice area (EROA) or tricuspid coaptation gap (TCG). Because of the inherent limitations associated with the EROA, we hypothesized that the TCG would be more suitable for defining VSTR and predicting outcomes.Materials and methodsIn this French multicentre retrospective study, we included 606 patients with ≥moderate-to-severe isolated functional TR (without structural valve disease or an overt cardiac cause) according to the recommendations of the European Association of Cardiovascular Imaging. Patients were further stratified into VSTR according to the EROA (≥60 mm2) and then according to the TCG (≥10 mm). The primary endpoint was all-cause mortality and the secondary endpoint was cardiovascular mortality.ResultsThe relationship between the EROA and TCG was poor (R2 = 0.22), especially when the size of the defect was large. Four-year survival was comparable between patients with an EROA &lt;60 mm2 vs. ≥60 mm2 (68 ± 3% vs. 64 ± 5%, p = 0.89). A TCG ≥10 mm was associated with lower four-year survival than a TCG &lt;10 mm (53 ± 7% vs. 69 ± 3%, p &lt; 0.001). After adjustment for covariates, including comorbidity, symptoms, dose of diuretics, and right ventricular dilatation and dysfunction, a TCG ≥10 mm remained independently associated with higher all-cause mortality (adjusted HR[95% CI] = 1.47[1.13–2.21], p = 0.019) and cardiovascular mortality (adjusted HR[95% CI] = 2.12[1.33–3.25], p = 0.001), whereas an EROA ≥60 mm2 was not associated with all-cause or cardiovascular mortality (adjusted HR[95% CI]: 1.16[0.81–1.64], p = 0.416, and adjusted HR[95% CI]: 1.07[0.68–1.68], p = 0.784, respectively)ConclusionThe correlation between the TCG and EROA is weak and decreases with increasing defect size. A TCG ≥10 mm is associated with increased all-cause and cardiovascular mortality and should be used to define VSTR in isolated significant functional TR.
Periprocedural outcome in patients undergoing left atrial appendage occlusion with the Watchman FLX device: The ITALIAN-FLX registry
Authors: Berti Sergio , De Caterina Alberto Ranieri , Grasso Carmelo , Casu Gavino , Giacchi Giuseppe , Pagnotta Paolo , Maremmani Michele , Mazzone Patrizio , Limite Luca , Tomassini Francesco , Greco Francesco , Romeo Maria Rita , Caramanno Giuseppe , Fassini Gaetano , Geraci Salvatore , Chiarito Mauro , Tondo Claudio , Tamburino Corrado , Contarini Marco 
Published: April 2023

IntroductionThe Watchman FLX is a novel device for transcatheter left atrial appendage occlusion (LAAO) specifically designed to improve procedural performance in more complex anatomies with a better safety profile. Recently, small prospective non-randomized studies have shown good procedural success and safety compared with previous experiences. Results from large multicenter registries are needed to confirm the safety and efficacy of the Watchman FLX device in a real-world setting.MethodsItalian FLX registry is a retrospective, non-randomized, multicentric study across 25 investigational centers in Italy including consecutive patients undergoing LAAO with the Watchman FLX between March 2019 and September 2021 (N = 772). The primary efficacy outcome was the technical success of the LAAO procedure (peri-device flow ≤ 5 mm) as assessed by intra-procedural imaging. The peri-procedural safety outcome was defined as the occurrence of one of the following events within 7 days after the procedure or by hospital discharge: death, stroke, transient ischemic attack, major extracranial bleeding (BARC type 3 or 5), pericardial effusion with tamponade or device embolization.ResultsA total of 772 patients were enrolled. The mean age was 76 ± 8 with a mean CHA2DS2-VASc score of 4.1 ± 1.4 and a mean HAS-BLED score of 3.7 ± 1.1. Technical success was achieved in 772 (100%) patients with the first device implanted in 760 (98.4%) patients. A peri-procedural safety outcome event occurred in 21 patients (2.7%) with major extracranial bleeding being the most common (1.7%). No device embolization occurred. At discharge 459 patients (59.4%) were treated with dual antiplatelet therapy (DAPT).ConclusionsThe Italian FLX registry represents the largest multicenter retrospective real-world study reporting periprocedural outcome of LAAO with the Watchman FLX device, resulting in a procedural success rate of 100% and a low incidence of peri-procedural major adverse events (2.7%).
Six-months clinical and intracoronary imaging follow-up after reverse T and protrusion or double-kissing and crush stenting for the treatment of complex left main bifurcation lesions
Authors: Abouelnour Amr EI , Olschewski Maximilian , Makmur Giulio , Ullrich Helen , Knorr Maike , Ahoopai Majid , Münzel Thomas , Gori Tommaso 
Published: April 2023

BackgroundThere is a debate regarding the best stent strategy for unprotected distal left main (LM) bifurcation disease. Among two-stent techniques, double-kissing and crush (DKC) is favored in current guidelines but is complex and requires expertise. Reverse T and Protrusion (rTAP) was shown to be a comparable strategy regarding short-term efficacy and safety, but with reduced procedural complexity.AimTo compare rTAP vs. DKC by optical coherence tomography (OCT) on the intermediate term.Methods52 consecutive patients with complex unprotected LM stenoses (Medina 0,1,1 or 1,1,1) were randomized to either DKC or rTAP and followed-up for a median of 189[180–263] days for clinical and OCT outcomes.ResultsAt follow-up OCT showed similar change in the side branch (SB) ostial area (primary endpoint). The confluence polygon showed a higher percentage of malapposed stent struts in the rTAP group that did not reach statistical significance (rTAP: 9.7[4.4–18.3] % vs. DKC: 3[0.07–10.9] %; p = 0.064). It also showed a trend towards larger neointimal area relative to the stent area (DKC: 8.8 [6.9 to 13.4] % vs. rTAP: 6.5 [3.9 to 8.9] %; p = 0.07), and smaller luminal area (DKC: 9.54[8.09–11.07] mm2 vs. rTAP: 11.21[9.53–12.42] mm²; p = 0.09) in the DKC group. The minimum luminal area in the parent vessel distal to the bifurcation was significantly smaller in the DKC group (DKC: 4.64 [3.64 to 5.34] mm² vs. rTAP: 6.76 [5.20 to 7.29] mm²; p = 0.03). This segment also showed a trend for smaller stent areas (p = 0.05 to 0.09), and a bigger neointimal area relative to the stent area (DKC: 8.94 [5.43 to 10.5]% vs. rTAP: 4.75 [0.08 to 8.5]%; p = 0.06) in the DKC patients. The incidence of clinical events was comparably low in both groups.ConclusionAt 6-months, OCT showed a similar change in the SB ostial area (primary endpoint) in rTAP compared to DKC. There was also a trend for smaller luminal areas in the confluence polygon and the distal parent vessel, and a larger neointimal area relative to the stent area, in DKC, along with a tendency for more malapposed stent struts in rTAP.Clinical Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT03714750, identifier: NCT03714750.
Teaching efficacy of undergraduate physical education students toward concepts in physical education
Authors: Spittle Sharna , Spittle Michael , Itoh Sho , Watt Anthony P. 
Published: April 2023

IntroductionThis study explored teaching efficacy for activities in physical education and how this efficacy relates to confidence and motivation in teaching physical education.MethodsStudents (n = 291, M age = 20.65 years, SD = 2.72) enrolled in a physical education degree course (Bachelor of Sport Science [Physical Education] or Bachelor of Education [P-12] [Primary Physical Education]) completed two questionnaires: the Physical Education Teaching Efficacy Scale (PETES) and Confidence and Motivation to Teach Primary Physical Education Questionnaire (CMTPPE) to measure teaching efficacy, and confidence and motivation teach physical education.ResultsParticipants reported lower teaching efficacy for applying scientific knowledge and teaching students with special needs, whereas they reported higher teaching efficacy for accommodating skill level differences and for instruction. Students were generally confident in management and planning in physical education, with 2nd and 3rd year students more confident than 1st year students. Intrinsic motivation for practice (to experience stimulating sensations of fun and excitement as motives for teaching physical education) and extrinsic motivation for performance (governed by rewards and restrictions by the teacher themselves) were the stronger forms of motivation for teaching physical education, whereas intrinsic motivation for knowledge (motivation teaching physical education for pleasure and satisfaction of learning new things) and disengagement (lack of motivation toward teaching physical education) were generally lower. Confidence and motivation were significantly related to teaching efficacy for most activities and confidence was more strongly related to teaching efficacy than motivation was. A path model of the relationships indicated that both year level and course influenced confidence, with confidence then influencing motivation and teaching efficacy for teaching activities in physical education.DiscussionThis study has highlighted the importance of confidence to motivation and self-efficacy for teaching activities in physical education. Practical implications include the identification of areas of lower teaching efficacy in teaching physical education and the relationships between confidence, motivation and self-efficacy in teaching activities in physical education.
Short-term effects of forest gap size on soil enzyme activity in a Platycladus orientalis plantation
Authors: Fei Fei , Chen Xinli , Guan Qingwei 
Published: April 2023

IntroductionSoil enzymes play a critical role in organic matter decomposition and nutrient cycling in forest ecosystems. However, the effects of forest gaps on soil enzyme activities remain uncertain.MethodsThis study aims to investigate the short-term effects of forest gap size on soil enzyme activities in Platycladus orientalis plantations. We conducted a study in a 50-year Platycladus orientalis plantation in Xuzhou, sampling soils from three levels of forest gap size (4 m radius, S; 8 m radius, M and 12 m radius, L) at different positions (within gap, edge, and outside the gap) and control plots (CK, no gaps) 2a after the creation of gaps. Soil peroxidase, dehydrogenase, urease, and invertase activities were measured.ResultsSpecifically, we found that M and S gaps had significantly (p &lt; 0.05) higher soil peroxidase activity at the outside position in April and October, respectively, than CK. Additionally, L gaps had significantly (p &lt; 0.05) higher soil dehydrogenase activity at the outside position in April than CK. Furthermore, L and S gaps had significantly (p &lt; 0.05) higher soil urease activity at the outside position in October and July, respectively, than CK. Lastly, L and S gaps had significantly (p &lt; 0.05) higher soil urease activity at the outside position in July than CK.ConclusionOur findings highlight the significant impact of canopy gaps on soil enzyme activities, which has important implications for forest management and conservation.
Stronger microbial nutrient limitations in subsoil along the precipitation gradient of agroecosystem: insights from soil enzyme activity and stoichiometry
Authors: Yang Jingjing , Guan Pingting , Zhang Peng , Wu Yunga , Wang Deli , Wu Donghui 
Published: April 2023

IntroductionSoil extracellular enzymes are central in terrestrial ecosystem responses to climate change, and their research can be crucial for assessing microbial nutrient demand. However, the effects of climate-induced precipitation patterns on soil microbial nutrient demand in different soil profiles of agroecosystems are rarely studied.MethodsHere, we present how the precipitation gradient affects soil enzymes related to carbon (C), nitrogen (N) and phosphorus (P) cycling and identified microbial nutrient limitation determinants at five depth intervals (0–10, 10–20, 20–30, 30–40, and 40–50 cm) in seven agroecosystems.Results and DiscussionWe found that N- and P-acquiring enzymes have a tendency to decrease or increase, respectively, but C-acquiring enzymes did not change along the precipitation gradient throughout soil profiles. Soil pH and moisture were the most important factors affecting the enzyme activity in 0–50 cm. Our results also revealed a crucial soil boundary (at 20 cm) that differentiated responses of microbial nutrient limitation to precipitation changes. In the topsoil (0–20 cm), the stoichiometry of soil nutrients did not vary with precipitation. Microbial P limitation was exacerbated with increased precipitation, which was controlled by soil pH and moisture in the topsoil. In contrast, in the subsoil (20–50 cm), soil nutrient stoichiometry decreased with increasing precipitation, and microbial C and P limitation displayed a positive correlation with precipitation. Furthermore, microbial P limitation tended to be stronger in the subsoil than in the topsoil along the precipitation gradient. Microbial C and P limitation was regulated by the soil nutrients and their stoichiometry in the subsoil. Our study is an essential step in soil enzyme activity and stoichiometry response to precipitation in agroecosystems and provides novel insights into understanding microbial nutrient limitation mechanisms in soil profiles along the precipitation gradient.
Cellular and humoral responses after second and third SARS-CoV-2 vaccinations in patients with autoimmune diseases treated with rituximab: specific T cell immunity remains longer and plays a protective role against SARS-CoV-2 reinfections
Authors: Egri Natalia , Calderón Hugo , Martinez Robert , Vazquez Mario , Gómez-Caverzaschi Verónica , Pascal Mariona , Araújo Olga , Juan Manel , González-Navarro Europa Azucena , Hernández-Rodríguez José 
Published: April 2023

BackgroundHumoral and cellular immune responses are known to be crucial for patients to recover from COVID-19 and to protect them against SARS-CoV-2 reinfection once infected or vaccinated.ObjectivesThis study aimed to investigate humoral and T cell responses to SARS-CoV-2 vaccination in patients with autoimmune diseases after the second and third vaccine doses while on rituximab and their potential protective role against reinfection.MethodsTen COVID-19-naïve patients were included. Three time points were used for monitoring cellular and humoral responses: pre-vaccine to exclude virus exposure (time point 1) and post-second and post-third vaccine (time points 2 and 3). Specific IgG antibodies were monitored by Luminex and T cells against SARS-CoV-2 spike-protein by ELISpot and CoVITEST. All episodes of symptomatic COVID-19 were recorded.ResultsNine patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and one with an undifferentiated autoimmune disease were included. Nine patients received mRNA vaccines. The last rituximab infusion was administered for a mean (SD) of 15 (10) weeks before the first vaccine and six patients were CD19-B cell-depleted. After a mean (SD) of 19 (10) and 16 (2) days from the second and third vaccine dose, IgG anti-SARS-CoV-2 antibodies were detected in six (60%) and eight (80%) patients, respectively. All patients developed specific T cell responses by ELISpot and CoVITEST in time points 2 and 3. Previous B cell depletion correlated with anti-SARS-CoV-2 IgG levels. Nine (90%) patients developed mild COVID-19 after a median of 7 months of the third dose.ConclusionRituximab in patients with autoimmune diseases reduces humoral responses but does not avoid the development of T cell responses to SARS-CoV-2 vaccination, which remain present after a booster dose. A steady cellular immunity appears to be protective against subsequent reinfections.