bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Covalent Organic Framework as a Long‐life and High‐Rate Anode Suitable for Both Aqueous Acidic and Alkaline Batteries
Authors: Lin Yilun , Cui Huilin , Liu Chao , Li Ran , Wang Shipeng , Qu Guangmeng , Wei Zhiquan , Yang Yihan , Wang Yaxin , Tang Zijie , Li Hongfei , Zhang Haiyan , Zhi Chunyi , Lv Haiming 
Published: January 2023

AbstractAqueous rechargeable batteries are prospective candidates for large‐scale grid energy storage. However, traditional anode materials applied lack acid‐alkali co‐tolerance. Herein, we report a covalent organic framework containing pyrazine (C=N) and phenylimino (−NH−) groups (HPP‐COF) as a long‐cycle and high‐rate anode for both acidic and alkaline batteries. The HPP‐COF′s robust covalent linkage and the hydrogen bond network between −NH− and water molecules collectively improve the acid‐alkaline co‐tolerance. More importantly, the hydrogen bond network promotes the rapid transport of H+/OH−by the Grotthuss mechanism. As a result, the HPP‐COF delivers a superior capacity and cycle stability (66.6 mAh g−1@ 30 A g−1, over 40000 cycles in 1 M H2SO4electrolyte; 91.7 mAh g−1@ 100 A g−1, over 30000 cycles @ 30 A g−1in 1 M NaOH electrolyte). The work opens a new direction for the structural design and application of COF materials in acidic and alkaline batteries.
Perfluoroalkyl Selenoxides, Selenones and Selenoximines: General Preparation and Properties
Authors: de Zordo‐Banliat Arnaud , Grollier Kevin , Vanthuyne Nicolas , Floquet Sébastien , Billard Thierry , Dagousset Guillaume , Pégot Bruce , Magnier Emmanuel 
Published: January 2023

AbstractA selective access to perfluoroalkyl selenoxides, via Oxone® as oxidant or to selenones by using a Polyoxometalate‐based Ionic Liquid (POM‐IL) as a catalyst for the oxidation step is described. The reaction works with various perfluoralkyl chains and substituents with satisfactory to excellent yields. A two‐step one‐pot reaction from selenocyanates was performed to gain access to perfluoroalkyl selenoxides. The previously unknown perfluoroalkyl selenoximines family was also prepared with good yields. Having unlocked two strategies for the synthesis of fluoroalkylated SeIV and SeVI compounds, we then evaluated the Hansch‐Leo lipophilicity parameters of these groups. Finally, asymmetric aryl perfluoroalkyl selenoximines were resolved to determine their absolute configurations.
Compliance With and Barriers to Implementing the Surgical Safety Checklist: A Mixed‐Methods Study
Authors: Aydin Akbuga Gökçen , Sürme Yeliz , Esenkaya Derya 
Published: January 2023

ABSTRACTThis mixed‐methods study aimed to determine nurses’ views on the use of the Turkish version of the World Health Organization's Surgical Safety Checklist (SSC). Phase 1 of the study consisted of a survey of perioperative and surgical nursing unit nurses’ perceptions on the use of the SSC. The results showed that personnel believed that every step of the checklist was not always applied and that an increased workload and the lack of team cooperation negatively affected the use of the checklist. Phase 2 of the study involved RN circulator interviews and focused on their experiences using the SSC, the obstacles to SSC implementation, and ways to increase compliance. We interviewed 126 nurses during phase 1 and 20 nurses during phase 2. We analyzed the interviews and identified three themes: the importance of using the SSC, barriers to using the checklist, and compliance with the checklist and applicability.
Reduction of Proinflammatory Effector Functions Through Remodeling of Fatty Acid Metabolism in CD8+ T Cells From Rheumatoid Arthritis Patients
Authors: Kraus Franziska V. , Keck Simon , Klika Karel D. , Graf Jürgen , Carvalho Rui A. , Lorenz Hanns‐Martin , Souto‐Carneiro M. Margarida 
Published: January 2023

ObjectiveRheumatoid arthritis (RA) CD8+ T cells maintain their effector proinflammatory phenotype by changing their metabolism toward aerobic glycolysis. However, their massive energy and biosynthesis needs may require additional substrates other than glucose. Since systemic alterations in lipid metabolism have been reported in RA patients, we explored the role of fatty acid (FA) metabolism in CD8+ T cells to identify potential targets to curb their proinflammatory potential.MethodsThe expression of FA metabolism–related genes was analyzed for total CD8+ T cells and CD8+ T cell subsets in the data of RA patients and healthy controls retrieved from the GEO database. Functional assays were performed using peripheral blood CD8+ T cells isolated from RA (n = 31), psoriatic arthritis (n = 26), and spondyloarthritis (n = 21) patients receiving different therapies (disease‐modifying antirheumatic drugs, biologics, and JAK inhibitors) and from healthy controls (n = 14). We quantified the expression of FA transporters, lipid uptake, intracellular FA content, cytokine production, activation, proliferation, and capacity to inhibit tumor cell growth, either with or without FA metabolism inhibitors.ResultsThe CD8+ T cell gene expression profile of FA metabolism–related genes was significantly different between untreated RA patients and healthy controls. RA patients who had a good clinical response after 6 months of methotrexate therapy had significantly increased expression of FA metabolism–related genes. Cell surface expression of the FA transporters FA binding protein 4 (FABP4) and G protein–coupled receptor 84 (GPR84) and FA uptake were higher in effector and memory CD8+ T cells from RA patients compared to those from healthy controls. In vitro blockade of FA metabolism significantly impaired CD8+ T cell effector functions.ConclusionRA CD8+ T cells present an altered FA metabolism, which could provide potential therapeutic targets to control their proinflammatory profile, particularly therapies directed against the transport and oxidation of free FA.image
Mechanistic Study of Chemoselectivity for Carbon Radical Hydroxylation versus Chlorination with FeIII(OH)(Cl) Complexes
Authors: Yang Miao , Chen Xiahe , Su Xingxing , She Yuan‐Bin , Yang Yun‐Fang 
Published: January 2023

AbstractThe FeIII(OH)(Cl) complex resembles the key intermediate proposed for the non‐heme iron halogenases. Goldberg and co‐workers reported that the FeIII(OH)(Cl) RC reacts with triphenylmethyl radical 1 to give an exclusive hydroxylation product. To understand the chemoselectivity of the reaction of RC with 1, density functional theory (DFT) calculations have been conducted. From RC, the competing pathways were identified as the OH‐transfer, Cl‐transfer, and isomerization pathways. The direct Cl‐transfer is more favorable than direct OH‐transfer by 2.8 kcal/mol. The hydrogen bonding interactions between the hydroxyl group and the pendent amine ligand impede the direct OH‐transfer from RC. Compared with the direct Cl‐transfer pathway, the isomerization pathways require lower barriers. In isomer RCiso2, the equatorial hydroxyl group, which has smaller diabatic bond dissociation energy, prefers to transfer to form the hydroxylation product. In FeIII(Cl)2 RC2 and RC2iso, the equatorial chloride group also prefers to transfer to give the chlorination product.
Comparative study of nearly‐grazing and fully‐grazing exoplanet system parameters derived with TESS and ground‐based instruments
Authors: Alexoudi Xanthippi , Dineva Ekaterina , Barnes Sydney , Strassmeier Klaus G. 
Published: January 2023

AbstractGrazing transiting systems are rare and difficult to parameterize due to their partial transit geometry. We investigated a sample of 43 nearly‐grazing to fully‐grazing transiting exoplanetary systems, using datasets provided by the Transiting Exoplanet Satellite Survey (TESS), aiming first to refine major system parameters. We focus on the two parameters, impact parameter and planetary radius , through a comparison of TESS light curves with ground‐based light curves. We investigate if there is a potential systematic trend between ground‐based and space‐based investigations that would possibly lead to a redefinition of the grazing nature of those exoplanetary systems. Our results have shown that the value is confirmed for most of the systems within , and refined significantly for Kilodegree Extremely Little Telescope (KELT)‐8 b, while the uncertainty on was improved for five systems with . The measurements of four systems were successfully refined, while the uncertainty of was improved for the majority of exoplanets with . Furthermore, a systematic trend is more pronounced for systems with , where there is a mean overestimation on the ground‐based derived by . We concluded eventually that from our sample only five systems are truly grazing, while four systems that were considered as grazing are not.
A new multi‐messenger description of starburst galaxies emission: perspectives for neutrino and gamma‐ray observations
Authors: Marinelli Antonio , Ambrosone Antonio , Chianese Marco , Fiorillo Damiano , Miele Gennaro , Pisanti Ofelia 
Published: January 2023

AbstractStar‐forming and starburst galaxies (SBGs), which are well‐known cosmic‐ray (CR) reservoirs, are expected to emit gamma rays and neutrinos predominantly via hadronic collisions. In this work we analyze the 10‐year Fermi‐Low Energy Technique (LAT) spectral energy distributions of 13 nearby galaxies by means of a physical model that accounts for high‐energy proton transport in starburst nuclei and includes the contribution of primary and secondary electrons. In particular, we test the hypothesis that the observed gamma‐ray fluxes are mostly due to star‐forming activity, which is in agreement with the available star formation rates coming from infrared (IR) and ultraviolet (UV) observations. Through this observation‐based approach, we determine the most‐likely neutrino counterparts from star‐forming and SBGs and quantitatively assess the ability of current and upcoming neutrino telescopes to detect them as point‐like sources. We also generate mock gamma‐ray data to simulate the Cherenkov Telescope Array (CTA) performance in detecting these sources. Moreover, we propose a test to discriminate between the two different CR transport models for the starburst nuclei by looking at the different gamma‐ray expectations. We point out that current data already gives a slight preference to CR models, which are dominated by advection.
Utility of a xanthene‐based dye for determination of nilotinib using two spectroscopic approaches. Applications to bulk powder, capsules, and spiked human plasma
Authors: Dagher Diaa , Elmansi Heba , Nasr Jenny Jeehan , El‐Enany Nahed 
Published: January 2023

AbstractNovel, selective, facile, and precise spectroscopic approaches were validated to determine nilotinib hydrochloride, a tyrosine kinase inhibitor used to treat patients with chronic myeloid leukemia. These approaches depend on the reaction of the tertiary amine group of nilotinib with erythrosine B in the Britton–Robinson buffer at pH 4. Method I, depends on measuring the absorbance of the formed complex at 551 nm. The absorbance concentration plot showed linearity over the concentration range of 1.0 to 9.0 μg/ml. Method II, involved the measurement of the quenching of the native fluorescence of erythrosine B by adding nilotinib in an acidic medium. The fluorescence quenching of erythrosine B was measured at 549 nm after excitation at 528 nm. This approach showed excellent linearity in the concentration range of 0.04 to 0.7 μg/ml. The limit of detection values for Method I and Method II were 0.225 and 0.008 μg/ml, respectively, while the limit of quantitation values for Method I and Method II were 0.68 and 0.026 μg/ml, respectively. To get the optimal conditions, factors that may affect the formation of the ion‐pairing complex were thoroughly examined. The two approaches were carefully validated following the International Conference of Harmonization (ICH Q2R1) guidelines. Statistical assessment of the results achieved using the suggested and previously published comparison approaches showed no significant difference. The approaches were successful in determining nilotinib in a pharmaceutical dosage form as well as spiked human plasma samples. The eco‐friendly properties of the methods were evaluated by three different tools.
Discovery of TRD‐93 as a novel DRAK2 inhibitor
Authors: Park Sangjun , Kye Seungmin , Jung Myoung Eun , Chae Chong Hak , Yang Kyung‐Min , Kim Seong‐Jin , Choi Gildon , Lee Kwangho 
Published: January 2023

AbstractDeath‐associated protein kinase‐related apoptosis‐inducing protein kinase 2 (DRAK2) has become a promising target for drug development. In search of novel and selective DRAK2 inhibitor motif, in vitro screen kinase assay was established performed using in‐house chemical libraries. After through hit triage procedure, N2‐(3,5‐dichlorophenyl)‐5‐fluoro‐N4‐methylpyrimidine‐2,4‐diamine (1) was selected as initial hit with structural novelty and drug‐likeness. During hit validation, structure–activity relationship of 1 was thoroughly disclosed and TRD‐93 was finally validated as hit for DRAK2 inhibition. TRD‐93 is small (mw = 290) but selectively potent to DRAK2 (IC50 = 0.16 μM) over other kinases including DAPK family kinases. Molecular binding model study of TRD‐93 to DRAK2 is also discussed.
Are sex differences in self‐estimated intelligence an elusive phenomenon? Exploring the role of working memory, creativity, and other psychological correlates in young and older adults
Authors: Giannouli Vaitsa 
Published: January 2023

AbstractBackgroundAlthough there is research examining the demographic predictors of self‐estimated intelligence (SEI) in young adults, so far SEI in old age is little investigated. This study aims to examine the influence of additional variables such as self‐estimated emotional intelligence (SEEQ), physical attractiveness, health, general optimism, religiousness, and working memory (WM) on SEI both in young and older adults.MethodsA total of 159 young (90 women, Mage = 28.77, SD = 8.83) and 152 older adults (93 women, Mage = 71.92, SD = 6.84) completed a measure of SEI as well as questions regarding the abovementioned variables. Given that WM is considered a very strong predictor of intelligence, neuropsychological assessment included the measurement of WM and phonologically cued semantic retrieval–verbal storage and processing in WM, as assessed by the Digit Span Forward and Verbal Fluency Task. The visual storage in WM was assessed with a variation of the Visual Patterns Test, and the visual storage and processing in WM with the Corsi blocks task (backward). Positive and Negative Affect Schedule (PANAS‐X) was also administered as a possible influence on cognitive performance and SEI.ResultsYoung males rated their intelligence quotient (IQ) and emotional quotient (EQ) higher than young females. This was not confirmed for older adults, for which surprisingly the reversed pattern was found. Older women reported higher IQ and EQ than older men. Correlations showed for all participants that the higher they rated their IQ, the higher their ratings of EQ, physical attractiveness, health, and religiousness. No significant correlations between objective tests regarding WM and SEI were found, supporting SEI overestimations. Age, sex, physical attractiveness, and SEEQ were significant predictors of SEI.DiscussionFor the first time, a reverse sex difference across age groups in SEI is found. Implications for individuals and healthcare professionals involved in assessment are suggested.
‘Letting you share when you need to share’: navigating the potential and precarity of friends and peers for UK young people after sexual abuse in adolescence
Authors: Warrington Camille , Allnock Debra , Soares Claire , Beckett Helen , Starbuck Lindsay 
Published: January 2023

AbstractThis article explores the rarely considered role of friends and peers supporting young people after sexual abuse experienced in adolescence, drawing on participatory research with 32 young people in the UK with lived experience. The article considers ways in which relationships with friends and peers interplay with recovery from abuse. This includes friends and peers as recipients of disclosure, conduits to professional support, sources of emotional support and distraction, and being embroiled in often challenging, precarious peer cultures that young people navigate post‐abuse. The article explores young people's rationale for, and experiences of, reaching out to friends and peers. It considers what young people seek and gain from these relationships in the aftermath of abuse, while acknowledging complex risks and precarity of these relationships. It argues that support from friends offers something distinct to family and professionals. It explores benefits of these relationships, but also potential for peer responses to undermine wellbeing if not sufficiently supportive or informed. The article ends by arguing for professionals to better recognise and respond to these relational contexts and consider whether there are safe and appropriate ways to ‘support young people to support’ without responsibilisation, and recognising welfare needs of those providing such support.
The Effects of Sunitinib in Healthy and Cisplatin‐Induced Rats
Authors: Demirtas Levent , Gürbüzel Mehmet , Akbas Emin Murat , Tahirler Hilal , Karatas Ozhan , Kemal Arslan Yusuf 
Published: January 2023

AbstractSunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine tumors. In this study, the effects of sunitinib given to rats, both alone and after stress with cisplatin, were investigated. The animals were divided into four groups – (1) control group (C) administered interperitoneally with a single dose 0.9 % saline, (2) Cis group administered a single dose (7 mg/kg) of cisplatin, (3) Sun group administered 10 mg/kg sunitinib for seven days, and (4) Cis+Sun group administered 10 mg/kg sunitinib for seven days after a single dose (7 mg/kg) of cisplatin. After these applications, the rats were sacrificed, and blood and tissue samples were taken for biochemical and histopathological evaluations. Sunitinib did not show any effect on urea, creatine, and kidney IL1β and TGF‐β3 expression levels when administered alone; it increased ALT, AST, and IL‐38 levels. When sunitinib was given to the cisplatin‐induced rats, it was observed that the increase in ALT, AST, and IL‐38 levels increased more than the rats that was given only sunitinib. According to the data obtained, sunitinib does not cause a significant change in kidney tissue under both normal and stress conditions, while it creates stress in liver tissue. In addition, its toxicity in the liver becomes more certain as a result of its combination with cisplatin.
Supporting student success centers to overcome common equity challenges
Authors: McMican Jairo 
Published: January 2023

AbstractStudent Success Centers (SSC) belong to a national network dedicated to increasing the number of students earning postsecondary credentials. SSCs use a variety of methods and strategies to help states within the network achieve these goals. This chapter focuses on practical ways for student success centers to help colleges navigate the complexities of addressing issues within diversity, equity, and inclusion (DEI) with a primary focus on equity. Using the eight most common equity challenges as a framework, this article addresses each challenge and then provides pragmatic solutions to overcome those challenges.
Systemic change: Developing an organizational strategy to increase faculty and staff diversity in California Community Colleges
Authors: Leal‐Carrillo Nadia , Gonzales Daisy , Lewis Jodi 
Published: January 2023

AbstractHistorically underserved and minoritized students are more likely to thrive when they are supported and led by diverse faculty and staff. In 2019, leaders of the country's largest higher education system, California Community Colleges, recognized wide gaps in representation: 52% of 2.1 million students identified as underrepresented minorities, compared to only 23% of tenured faculty and 22% of adjunct faculty. Similarly, only 41% of staff who interacted daily with students were from an underrepresented group. Addressing this barrier to student success was critical for the system to achieve its ambitious Vision for Success goals. This case study explores how the Success Center for California Community Colleges collaborated with the Chancellor's Office, faculty representatives, and other partners to develop a system‐wide organizational strategy to hire and support a workforce as diverse as the students they serve.
Using data to cultivate a culture of evidence: Case studies from two states
Authors: Konruff Ben , Barker Hilary , Foster Anne , Weber Garratt 
Published: January 2023

AbstractThis chapter explores how the Wisconsin Technical College System Student Success Center and the Success Center for Ohio Community Colleges provided support that encouraged data‐informed decision‐making among 2‐year college stakeholders. A case study for each Center is presented to illustrate data‐related strategies and lessons learned. The presented findings may be useful to other Student Success Centers and colleges as they engage in efforts to establish a culture of evidence where data is used to inform equitable educational policy, practice, and strategy.
Creating a culture of student success innovation through institutional coaching
Authors: Miller Jennifer M. , Wetzstein Lia , Girardi Amy 
Published: January 2023

AbstractThis chapter highlights the role of institutional coaches in supporting community college transformational reform efforts, such as guided pathways. The history of coaching support for student success is explored along with a description of a national network of state intermediaries supporting the work of coaches focused on campus‐level change. Specific examples of how coaching creates a culture of student success innovation and support is provided from three states.
Necessary change: What student success centers can do to support more equitable student success
Authors: Bragg Debra D. 
Published: January 2023

AbstractAddressing the Student Success Center Network's newly adopted statement on racial equity and economic recovery, this chapter describes actions the student success centers and their affiliated college networks are taking to address policies and practices that perpetuate systemic inequalities and recommends additional steps to enhance educational and economic outcomes for racially minoritized students.
Paraduodenal hernia: An exceptional cause of acute bowel obstruction
Authors: Trabelsi Med Mehdi , Oueslati Annouar , Kammoun Mehdi , Jerraya Hichem , Bouasker Ibtissem , Nouira Ramzi 
Published: January 2023

AbstractInternal hernias represent only 0.2%–0.9% of all causes of bowel obstruction. A 59‐year‐old patient presented urgently with small bowel obstruction. Laparotomy revealed a left paraduodenal hernia with most of the small bowel herniating through a space between the inferior mesenteric vein and duodenojejunal junction.