bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Storytelling: Changing Learners’ Attitudes and Self-efficacy Beliefs
Authors: Tecedor Marta 
Published: February 2023

Abstract
This study examines the impact of writing instruction on Spanish heritage language (SHL) learners’ attitudes towards digital stories (DS) and self-efficacy beliefs with regard to academic writing, multiliteracies, and computer abilities. Two types of writing instruction—a traditional curriculum centered around genres and a multiliteracies curriculum consisting of the interpretation and design of DSs—were implemented in fourth and fifth-semester SHL courses at a US university in the Southwest. Drawing on Gardner’s (1985) conceptualization of attitude, and Bandura’s (1991) construct of perceived self-efficacy, a survey was designed to explore changes in participants’ (n = 225) scores before and after the treatments. Confirmatory factor analysis was conducted to determine the reliability of the instrument and a latent mean structure analysis was used to explore differences among groups before and after the 16-week intervention period. Findings indicate that curricular changes aimed at developing multiliteracies benefitted participants in two of the four domains under examination: attitude towards DSs and self-efficacy in multiliteracies abilities. Areas in which participants exposed to the multiliteracies curriculum did not experience a positive impact—self-efficacy in academic writing abilities and computer abilities—provide insights into how multiliteracies abilities develop and potential modifications that can be implemented in the curriculum to maximize its positive impact.
The Best Under Stress: An Analysis of Breast Tissue Expander Response to External Forces
Authors: Najafali Daniel , Liu Farrah C , Raman Karanvir , Maheta Bhagvat , Saldana Golddy Milagros , Heldman Lucas , Cevallos Priscila , Nazerali Rahim 
Published: February 2023

Abstract

Background
The use of breast tissue expanders (TEs) in breast reconstruction is accompanied by undesired changes to the chest wall and lateral plane. Breast TEs are designed to create a naturally formed breast pocket by capitalizing on the ductile response of skin tissue; however, in practice, the use of expanders is accompanied by undesired changes to the chest wall and lateral plane.

Objectives
The authors of this study compared 3 comparably sized and commercially available breast TEs to assess the mechanical profile and functionality of each design.

Methods
Authors compared MENTOR Artoura PLUS Smooth (Irvine, CA), Allergan 133 Smooth (Irvine, CA), and Sientra AlloX2 Smooth (Santa Barbara, CA) filled to 100% of their label volume. The mechanical profile of TEs was assessed via vertical compression. Dimensions were recorded at baseline and percent changes were calculated at each compressive load (5-35 lbf intervals of 5 lbf).

Results
Base width and projection were recorded at compressive loads of 10, 20, and 35 lbs. For percent changes of base width, MENTOR had 0.98%, 2.09%, 3.84%; Allergan 4.21%, 9.15%, 15.52%; and Sientra 4.72%, 10.19%, 19.15%. For percent changes of projection, MENTOR had −19.06%, −25.44%, −30.88%, Allergan −35.53%, −42.90%, −50.09%, and Sientra −29.64%, −37.68%, −44.69%. For percent change of height, MENTOR had 1.44%, 2.62%, 4.27%, Allergan 10.26%, 16.49%, 22.97%, and Sientra 6.99%, 11.93%, 16.90%. MENTOR's TE had the most pronounced lower pole with volume expansion.

Conclusions
The MENTOR TE demonstrated the least lateral deformation and projection loss across the range of compressive loads, as well as the highest force resistance compared with the other models.

Level of Evidence: 3
Epileptogenesis in tuberous sclerosis complex-related developmental and epileptic encephalopathy
Authors: Aronica Eleonora , Specchio Nicola , Luinenburg Mark J , Curatolo Paolo 
Published: February 2023

AbstractEpileptogenesis in infants with tuberous sclerosis complex (TSC) is a gradual and dynamic process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and pathophysiologic mechanisms, including mammalian target of rapamycin (mTOR) dysregulation, GABAergic dysfunction and abnormal connectivity, may play a role in this epileptogenic process and may also contribute to the associated developmental encephalopathy. Disease-specific antiseizure medications or drugs targeting the mTOR pathway have proved to be effective in TSC-associated epilepsy. Pre-symptomatic administration of vigabatrin, a GABAergic drug, delays seizure onset and reduces the risk of a subsequent epileptic encephalopathy, such as infantile spasms syndrome or Lennox–Gastaut syndrome. Everolimus, a rapamycin-derived mTOR inhibitor, reduces seizure frequency, especially in younger patients. This evidence suggests that everolimus should be considered early in the course of epilepsy.Future trials are needed to optimize the use of everolimus and determine whether earlier correction of mTOR dysregulation can prevent progression to developmental and epileptic encephalopathies or mitigate their severity in infants with TSC. Clinical trials of several other potential antiseizure drugs (cannabidiol and ganaxolone) that target contributing mechanisms are also underway.This review provides an overview of the different biological mechanisms occurring in parallel and interacting throughout the life course, even beyond the epileptogenic process, in individuals with TSC. These complexities highlight the challenges faced in preventing and treating TSC-related developmental and epileptic encephalopathy.
Reliability and validity of a measure to assess the health-related quality of life of women with alopecia areata
Authors: Rees Huw , Wall Dmitri , Bokhari Laita , Asfour Leila , Sinclair Rodney 
Published: February 2023

Abstract
Alopecia areata (AA) has an impact on health-related quality of life (HRQoL). The Women’s Androgenetic Alopecia Quality of Life (WAA-QoL) questionnaire is a reliable, validated HRQoL measure in women with androgenetic alopecia (AGA). There is no equivalent measure for female patients with AA. Data were collected as part of the Global Registry of Alopecia Areata Disease Severity and Treatment Safety (GRASS) Australia. The WAA-QoL, Dermatology Life Quality Index (DLQI) and Skindex-16 for AA, as well as the Severity of Alopecia Tool score, were extracted from GRASS for adult female patients. Cronbach’s alpha and factor analysis were employed to determine the internal consistency of the measure, and nonparametric correlation testing assessed the validity of the questionnaire. Overall, 137 individuals completed the questionnaires. There was excellent internal consistency of the WAA-QoL among women with AA (Cronbach’s α = 0.98). A moderate and high positive correlation was found between the WAA-QoL and the DLQI and the Skindex-16 for AA, respectively. The WAA-QoL is a reliable and valid assessment of HRQoL among women with AA.
Concordance Between Initial Presumptive and Final Adjudicated Diagnoses of Infection Among Patients Meeting Sepsis-3 Criteria in the Emergency Department
Authors: Hooper Gabriel A , Klippel Carolyn J , McLean Sierra R , Stenehjem Edward A , Webb Brandon J , Murnin Emily R , Hough Catherine L , Bledsoe Joseph R , Brown Samuel M , Peltan Ithan D 
Published: February 2023

Abstract

Background
Guidelines emphasize rapid antibiotic treatment for sepsis, but infection presence is often uncertain at initial presentation. We investigated the incidence and drivers of false-positive presumptive infection diagnosis among emergency department (ED) patients meeting Sepsis-3 criteria.

Methods
For a retrospective cohort of patients hospitalized after meeting Sepsis-3 criteria (acute organ failure and suspected infection including blood cultures drawn and intravenous antimicrobials administered) in 1 of 4 EDs from 2013 to 2017, trained reviewers first identified the ED-diagnosed source of infection and adjudicated the presence and source of infection on final assessment. Reviewers subsequently adjudicated final infection probability for a randomly selected 10% subset of subjects. Risk factors for false-positive infection diagnosis and its association with 30-day mortality were evaluated using multivariable regression.

Results
Of 8267 patients meeting Sepsis-3 criteria in the ED, 699 (8.5%) did not have an infection on final adjudication and 1488 (18.0%) patients with confirmed infections had a different source of infection diagnosed in the ED versus final adjudication (ie, initial/final source diagnosis discordance). Among the subset of patients whose final infection probability was adjudicated (n = 812), 79 (9.7%) had only “possible” infection and 77 (9.5%) were not infected. Factors associated with false-positive infection diagnosis included hypothermia, altered mental status, comorbidity burden, and an “unknown infection source” diagnosis in the ED (odds ratio: 6.39; 95% confidence interval: 5.14–7.94). False-positive infection diagnosis was not associated with 30-day mortality.

Conclusions
In this large multihospital study, &lt;20% of ED patients meeting Sepsis-3 criteria had no infection or only possible infection on retrospective adjudication.
Internationally Driven, but Domestically Aware, Legislation in Troubled Times: The First Copyright Statute in China
Authors: Lee Jyh-An , Li Yangzi 
Published: February 2023

Abstract
We use the 1910 Copyright Code of the Great Qing Dynasty (Qing Copyright Code) as a lens to understand China’s initial encounter with international intellectual property norms, examine the dynamic political economy in which the law was enacted, and provide an overview of the structure and important provisions of the Qing Copyright Code. We argue that, although foreign pressure was an important factor shaping the Qing Copyright Code, the Code was designed not to protect the economic interests of foreigners in China but to achieve a pair of distinct goals: advance China’s national interests in accessing Western knowledge and incentivize the production and dissemination of knowledge in the country. This argument is substantiated by not only the political economy of the legislation but also the later implementation of the law.
Concomitant aortic root replacement during frozen elephant trunk implantation does not increase perioperative risk
Authors: Berger Tim , Chikvatia Salome , Siepe Matthias , Kondov Stoyan , Meissl Dominic , Gottardi Roman , Rylski Bartosz , Czerny Martin , Kreibich Maximilian 
Published: February 2023

AbstractOBJECTIVESOur aim was to evaluate the risk of concomitant aortic root replacement during frozen elephant trunk (FET) total arch replacement.METHODSBetween March 2013 and February 2021, 303 patients underwent aortic arch replacement using the FET technique. Patient characteristics, intra- and postoperative data were compared between patients with (n = 50) and without (n = 253) concomitant aortic root replacement (implantation of a valved conduit or using the reimplantation valve-sparing technique) after propensity score matching.RESULTSAfter propensity score matching, there were no statistically significant differences in preoperative characteristics including the underlying pathology. There was no statistically significant difference regarding arterial inflow-cannulation or concomitant cardiac procedures, while cardiopulmonary bypass (P &lt; 0.001) and aortic cross-clamp (P &lt; 0.001) times were significantly longer in the root replacement group. Postoperative outcome was similar between the groups and there were no proximal reoperations in the root replacement group during follow-up. Root replacement was not predictive for mortality (P = 0.133, odds ratio: 0.291) in our Cox regression model. There was no statistically significant difference in overall survival (log rank: P = 0.062).CONCLUSIONSConcomitant FET implantation and aortic root replacement prolongs operative times but does not influence postoperative outcomes or increase operative risk in an experienced high-volume centre. The FET procedure did not appear to be a contraindication for concomitant aortic root replacement even in patients with borderline indications for aortic root replacement.
Outcomes of type A acute aortic dissection with cardiopulmonary arrest: Tokyo Acute Aortic Super-network Registry
Authors: Yamasaki Manabu , Yoshino Hideaki , Kunihara Takashi , Akutsu Koichi , Shimokawa Tomoki , Ogino Hitoshi , Kawata Mitsuhiro , Takahashi Toshiyuki , Usui Michio , Watanabe Kazuhiro , Fujii Takeshiro , Yamamoto Takeshi , Nagao Ken , Takayama Morimasa 
Published: February 2023

AbstractOBJECTIVESPreventing loss of life in patients with type A acute aortic dissection (AAD) who present with cardiopulmonary arrest (CPA) can be extremely difficult. Thus, we investigated the early outcomes in these patients.METHODSPatients with type A AAD who were transported to hospitals belonging to the Tokyo Acute Aortic Super-network between January 2015 and December 2019 were considered for this study. We assessed the early mortality of these patients presenting with CPA and also investigated the differences in outcomes between patients with out-of-hospital and in-hospital CPA.RESULTSA total of 3307 patients with type A AAD were transported, 434 (13.1%) of whom presented with CPA. The overall mortality of patients presenting with CPA was 88.2% (383/434), of which 94.5% (240/254) experienced out-of-hospital CPA and 79.4% (143/180) experienced in-hospital CPA (P &lt; 0.001). Multivariable analysis revealed that aortic surgery [odds ratio (OR), 0.022; 95% confidence interval (CI), 0.008–0.060; P &lt; 0.001] and patient age over 80 years (OR, 2.946; 95% CI, 1.012–8.572; P = 0.047) were related with mortality in patients with type A AAD and CPA. Between in-hospital and out-of-hospital CPA, the proportions of DeBakey type 1 (OR, 2.32; 95% CI, 1.065–5.054; P = 0.034), cerebral malperfusion (OR, 0.188; 95% CI, 0.056–0.629; P = 0.007), aortic surgery (OR, 0.111; 95% CI, 0.045–0.271; P = 0.001), age (OR, 0.969; 95% CI, 0.940–0.998; P = 0.039) and the time from symptom onset to hospital admission (OR, 1.122; 95% CI, 1.025–1.228; P = 0.012) were significantly different.CONCLUSIONSPatients with type A AAD presenting with CPA exhibited extremely high rates of death. Patient outcomes following in-hospital CPA tended to be better than those following out-of-hospital CPA; however, this difference was not significantly different. To prevent deaths, aortic surgery, when possible, should be considered in patients with type A AAD who sustained CPA.
Young adults’ labour market transitions and intergenerational support in Germany
Authors: Manzoni Anna , Gebel Michael 
Published: February 2023

Abstract
Research has shown that parents provide considerable support to their children; however, we know little about the influence of young adults’ employment experiences on the support they receive from their parents. We draw on data from the German Family Panel pairfam for birth cohorts 1981–1983 and 1991–1993 and use a first difference panel estimator with asymmetric effects to examine the extent to which young adults’ employment transitions affect material, emotional, and instrumental support from parents. We find stark differences across types of support: parental material support changes in response to transitions in and out of employment, especially when to and from education. Other types of support seem less contingent on labour market transitions. Instrumental support only increases for transitions from education to employment and from employment to NEET. The latter effect is mainly driven by women entering parental leave. We do not find strong evidence of differences between transitions to standard and non-standard work. The association between employment transitions and intergenerational material support flows suggests that families act as safety nets, raising concerns about those whose families are unable to help.
Intensity-specific considerations for exercise for patients with inflammatory bowel disease
Authors: Ordille Andrew J , Phadtare Sangita 
Published: February 2023

AbstractThe rising prevalence of inflammatory bowel disease (IBD) necessitates that patients be given increased access to cost-effective interventions to manage the disease. Exercise is a non-pharmacologic intervention that advantageously affects clinical aspects of IBD, including disease activity, immune competency, inflammation, quality of life, fatigue, and psychological factors. It is well established that exercise performed at low-to-moderate intensity across different modalities manifests many of these diseased-related benefits while also ensuring patient safety. Much less is known about higher-intensity exercise. The aim of this review is to summarize findings on the relationship between strenuous exercise and IBD-related outcomes. In healthy adults, prolonged strenuous exercise may unfavorably alter a variety of gastrointestinal (GI) parameters including permeability, blood flow, motility, and neuro-endocrine changes. These intensity- and gut-specific changes are hypothesized to worsen IBD-related clinical presentations such as diarrhea, GI bleeding, and colonic inflammation. Despite this, there also exists the evidence that higher-intensity exercise may positively influence microbiome as well as alter the inflammatory and immunomodulatory changes seen with IBD. Our findings recognize that safety for IBD patients doing prolonged strenuous exercise is no more compromised than those doing lower-intensity work. Safety with prolonged, strenuous exercise may be achieved with adjustments including adequate hydration, nutrition, drug avoidance, and careful attention to patient history and symptomatology. Future work is needed to better understand this intensity-dependent relationship so that guidelines can be created for IBD patients wishing to participate in high-intensity exercise or sport.
Egg Yolk Protein Homologs Identified in Live-Bearing Sharks: Co-Opted in the Lecithotrophy-to-Matrotrophy Shift?
Authors: Ohishi Yuta , Arimura Shogo , Shimoyama Koya , Yamada Kazuyuki , Yamauchi Shinya , Horie Taku , Hyodo Susumu , Kuraku Shigehiro 
Published: February 2023

AbstractReproductive modes of vertebrates are classified into two major embryonic nutritional types: yolk deposits (i.e., lecithotrophy) and maternal investment (i.e., matrotrophy). Vitellogenin (VTG), a major egg yolk protein synthesized in the female liver, is one of the molecules relevant to the lecithotrophy-to-matrotrophy shift in bony vertebrates. In mammals, all VTG genes are lost following the lecithotrophy-to-matrotrophy shift, and it remains to be elucidated whether the lecithotrophy-to-matrotrophy shift in nonmammalians is also associated with VTG repertoire modification. In this study, we focused on chondrichthyans (cartilaginous fishes)—a vertebrate clade that underwent multiple lecithotrophy-to-matrotrophy shifts. For an exhaustive search of homologs, we performed tissue-by-tissue transcriptome sequencing for two viviparous chondrichthyans, the frilled shark Chlamydoselachus anguineus and the spotless smooth-hound Mustelus griseus, and inferred the molecular phylogeny of VTG and its receptor very low-density lipoprotein receptor (VLDLR), across diverse vertebrates. As a result, we identified either three or four VTG orthologs in chondrichthyans including viviparous species. We also showed that chondrichthyans had two additional VLDLR orthologs previously unrecognized in their unique lineage (designated as VLDLRc2 and VLDLRc3). Notably, VTG gene expression patterns differed in the species studied depending on their reproductive mode; VTGs are broadly expressed in multiple tissues, including the uterus, in the two viviparous sharks, and in addition to the liver. This finding suggests that the chondrichthyans VTGs do not only function as the yolk nutrient but also as the matrotrophic factor. Altogether, our study indicates that the lecithotrophy-to-matrotrophy shift in chondrichthyans was achieved through a distinct evolutionary process from mammals.
An Interpretation of Articles 18-23 of Directive (EU) 2019/790: Open Issues in Contractual Copyright and Related Rights Law
Authors: Bossi Ludovico 
Published: February 2023

Abstract
Although creators have always been placed at the centre of the copyright system, they generally face difficulties in being fairly remunerated for their work. Articles 18-23 Directive (EU) 2019/790 require Member States to establish a series of protective measures in favour of authors and performers who license or transfer the exclusive economic rights to their works or performances to third parties for the purpose of exploitation. These measures constitute an absolute novelty at the European Union level and at the level of most Member States, and present a potential which must not be wasted. However, these provisions are in many ways complex and ambiguous, so that their effectiveness could be undermined in various ways. This article focuses on some still open issues concerning Arts. 18-23 Directive (EU) 2019/790 and attempts to provide the most appropriate interpretation in order to achieve the intended goals. In doing so, particular attention is paid to previous fragmented national and European experiences in the field of contractual copyright and related rights law.
Exploring balanced harvest as a potential strategy for highly exploited multispecies fisheries
Authors: Sun Runlong , Sun Peng , Fu Caihong , Liu Guankui , Liang Zhenlin , Shin Yunne-Jai , Barrier Nicolas , Tian Yongjun 
Published: February 2023

Abstract
Balanced harvest (BH) proposes moderate fishing mortality rates across all species or sizes in proportion to productivity, serving as a possible strategy for ecosystem-based fisheries management. Fishing patterns in some developing countries (e.g. China, the largest producer of seafood) closely resemble BH, where catches have been highly diversified by unselective gears due to market demand for almost all species. In this study, we employed an OSMOSE ecosystem model developed for the Yellow Sea in China to investigate the potential occurrences and advantages of BH in this region with highly exploited multispecies fisheries. Simulations were carried out under four types of fishing scenarios, where various levels of fishing mortality rates for all species or specific functional groups were implemented. Results indicated that the occurrences of BH depended on fishing pressure and targeted functional groups, and that size-level BH was significantly correlated with biomass and yield for most species. In particular, varying fishing pressure for certain functional groups resulted in BH, which produced a high yield for specific species and ensured their biomass sustainability. We concluded that the benefits of BH could be potentially achieved by adjusting fishing pressure for certain functional groups based on the existing fishing pattern in over-exploited ecosystems.
Dead Users’ Profiles on Facebook: Limited Interaction Beyond Human Existence
Authors: Trevisan Daniele , Maciel Cristiano , Pereira Vinícius Carvalho , Pereira Roberto 
Published: February 2023

Abstract
Death has become increasingly visible on social networks, especially after COVID-19, and Facebook addresses that with double standards: while some profiles remain active, others turn into memorials. This article investigates how Facebook’s system deals with dead users’ profiles either to support or restrict interactions concerning users’ deaths. Our qualitative analysis of data from 54 public profiles of people who died between June 2020 and March 2021 showed that (i) Facebook fails to communicate the criteria for transforming profiles into memorials; (ii) no information about their contacts of deceased users’ profiles is given; (iii) the frequency of interaction with memorials and with active profiles is different; (iv) profiles’ privacy settings shape interaction. Our results exemplify how a sociotechnical system influences people’s interactions with dead users’ profiles. We herein highlight implications for interaction design and evaluation, besides the need to consider interaction as existence, which raises big challenges to the Human Computer Interaction (HCI) community.