bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole body irradiation with intensity-modulated helical tomotherapy prior to haematopoietic stem cell transplantation: analysis of organs at risk by dose and its effect on blood kinetics
Authors: Köksal Mümtaz , Baumert Jonathan , Jazmati Danny , Schoroth Felix , Garbe Stephan , Koch David , Scafa Davide , Sarria Gustavo R. , Leitzen Christina , Massoth Gregor , Delis Achilles , Heine Annkristin , Holderried Tobias , Brossart Peter , Müdder Thomas , Schmeel Leonard C. 
Published: March 2023

Abstract
Background
Intensity-modulated helical tomotherapy (HT) is a promising technique in preparation for bone marrow transplantation. Nevertheless, radiation-sensitive organs can be substantially compromised due to suboptimal delivery techniques of total body irradiation (TBI). To reduce the potential burden of radiation toxicity to organs at risk (OAR), high-quality coverage and homogeneity are essential. We investigated dosimetric data from kidney, lung and thorax, liver, and spleen in relation to peripheral blood kinetics. To further advance intensity-modulated total body irradiation (TBI), the potential for dose reduction to lung and kidney was considered in the analysis.

Patients and methods
46 patients undergoing TBI were included in this analysis, partially divided into dose groups (2, 4, 8, and 12 Gy). HT was performed using a rotating gantry to ensuring optimal reduction of radiation to the lungs and kidneys and to provide optimal coverage of other OAR. Common dosimetric parameters, such as D05, D95, and D50, were calculated and analysed. Leukocytes, neutrophils, platelets, creatinine, GFR, haemoglobin, overall survival, and graft-versus-host disease were related to the dosimetric evaluation using statistical tests.

Results
The mean D95 of the lung is 48.23%, less than half the prescribed and unreduced dose. The D95 of the chest is almost twice as high at 84.95%. Overall liver coverage values ranged from 96.79% for D95 to 107% for D05. The average dose sparing of all patients analysed resulted in an average D95 of 68.64% in the right kidney and 69.31% in the left kidney. Average D95 in the spleen was 94.28% and D05 was 107.05%. Homogeneity indexes ranged from 1.12 for liver to 2.28 for lung. The additional significance analyses conducted on these blood kinetics showed a significant difference between the 2 Gray group and the other three groups for leukocyte counts. Further statistical comparisons of the dose groups showed no significant differences. However, there were significant changes in the dose of OAR prescribed with dose sparing (e.g., lung vs. rib and kidney).

Conclusion
Using intensity-modulated helical tomotherapy to deliver TBI is a feasible method in preparation for haematopoietic stem cell transplantation. Significant dose sparing in radiosensitive organs such as the lungs and kidneys is achievable with good overall quality of coverage. Peripheral blood kinetics support the positive impact of HT and its advantages strongly encourage its implementation within clinical routine.
Differentiated goods in a dynamic Cournot duopoly with emission charges on output
Authors: Naimzada Ahmad , Pireddu Marina 
Published: March 2023

AbstractWe extend the dynamic Cournot duopoly framework with emission charges on output by Mamada and Perrings (Econ Anal Policy 66:370–380, 2020), which encompassed homogeneous products in its original formulation, to the more general case of differentiated goods, in order to highlight the richness in its static and dynamic outcomes. Each firm is taxed proportionally to its own emission only and charge functions are quadratic. Moreover, due to an adjustment capacity constraint, firms partially modify their output level toward the best response. Like in Mamada and Perrings (Econ Anal Policy 66:370–380, 2020), the only steady state coincides with the Nash equilibrium, and it will be considered admissible when it guarantees the positivity of the marginal emission charge. We find that the full efficacy of the environmental policy, which applies to an equilibrium that is globally asymptotically stable anytime it is admissible, is achieved in the case of independent goods, as well as with a low good interdependence degree in absolute value, independently of being substitutes or complements. When goods are substitutes and their interdependence degree is high, the considered environmental policy is still able to reduce pollution at the equilibrium, but the latter is stable just when the policy intensity degree is large enough. When instead goods are complements and their interdependence degree is high in absolute value, the considered environmental policy produces detrimental effects on the pollution level and the unique equilibrium is always unstable, when admissible. This highlights that, from the static viewpoint, even in the absence of free riding possibilities, the choice of the mechanism to implement has to be carefully pondered, according to the features of the considered economy.
Improving active participation during enterprise operations modeling with an extended story-card-method and participative modeling software
Authors: De Vries Marne , Opperman Petra 
Published: March 2023

Abstract
The COVID-19 pandemic emphasized the need for process automation, using agile software development practices. However, when agile methods are used in scaled contexts, many software development efforts fail, mainly due to lacking requirements engineering practices. When business-oriented software needs to be developed within a scaled context, the story-card method (SCM), developed as part of a previous study, assists in structuring emerging software requirements within a taxonomy that represents enterprise operation. The SCM helps agile team members to develop a common understanding about enterprise operation when they construct the enterprise operation taxonomy. Digital participatory enterprise modeling (PEM) may increase collaboration and understanding among team members, especially when team members are geographically dispersed, when they co-model their understanding of enterprise operations. Using design science research to further evolve the existing SCM, we identified two concerns regarding the existing SCM: (1) The modeling software did not encourage active participation during modeling, and (2) Low quality of the resulting cooperation structure diagram (CSD) that is used to derive an enterprise operation taxonomy, i.e., the need to further extend the existing SCM. As main contribution of this article, we addressed previous deficiencies of the SCM, developing an extended SCM (eSCM), based on principles and guidelines that would encourage online participation during PEM, also providing a comprehensive case to demonstrate the eSCM. As a second contribution, we used survey-feedback from research participants, as well as activity tracking to evaluate whether the modeling tool encouraged active PEM. Our third contribution is to evaluate the quality of the resulting CSDs with suggestions for future improvement.
Admitting privileges: A construction ecology perspective on the unintended consequences of medical school admissions
Authors: Taylor Janelle S. , Wendland Claire L. , Kulasegaram Kulamakan , Hafferty Frederic W. 
Published: March 2023

AbstractMedical-school applicants learn from many sources that they must stand out to fit in. Many construct self-presentations intended to appeal to medical-school admissions committees from the raw materials of work and volunteer experiences, in order to demonstrate that they will succeed in a demanding profession to which access is tightly controlled. Borrowing from the field of architecture the lens of construction ecology, which considers buildings in relation to the global effects of the resources required for their construction, we reframe medical-school admissions as a social phenomenon that has far-reaching harmful unintended consequences, not just for medicine but for the broader world. Illustrating with discussion of three common pathways to experiences that applicants widely believe will help them gain admission, we describe how the construction ecology of medical school admissions can recast privilege as merit, reinforce colonizing narratives, and lead to exploitation of people who are already disadvantaged.
Intervention Programs Targeting the Mental Health, Professional Burnout, and/or Wellbeing of School Teachers: Systematic Review and Meta-Analyses
Authors: Beames Joanne R. , Spanos Samantha , Roberts Anna , McGillivray Lauren , Li Sophie , Newby Jill M. , O’Dea Bridianne , Werner-Seidler Aliza 
Published: March 2023

AbstractThis paper outlines a systematic review and meta-analyses to identify, describe, and evaluate randomised and non-randomised controlled trials of psychological programs targeting the mental health, professional burnout, and/or wellbeing of school classroom teachers. Eighty-eight unique studies were identified for inclusion in the review, and of those 46 were included in the meta-analyses (23 randomised controlled trials). In randomised controlled trials, the programs examined had large effects on stress (g=0.93), and moderate effects on anxiety (g=0.65), depression (g=0.51), professional burnout (g=0.57), and wellbeing (g=0.56) at post. In non-randomised controlled trials, programs had moderate effects on stress (g=0.50), and small effects on anxiety (g=0.38) and wellbeing (g=0.38) at post. Studies were heterogeneous in design and methodological quality was generally poor, particularly in non-randomised controlled trials. There was an inadequate number of comparisons to perform sub-group analyses, meta-regression, or publication bias analyses. Most of the programs examined required significant time, effort, and resources to deliver and complete. These programs may not translate well outside of research trials to real-world contexts due to teachers being time-poor. Priorities for research include using methodologically rigorous designs, developing programs for teachers with teachers (i.e. co-design), and considering implementation factors to ensure feasibility, acceptability, and uptake. Systematic Review Registration Number: PROPSERO - CRD42020159805.
High-performance IN738 superalloy derived from turbine blade waste for efficient ethanol, ethylene glycol, and urea electrooxidation
Authors: Hefnawy Mahmoud A. , Medany Shymaa S. , El-Sherif Rabab M. , El-Bagoury Nader , Fadlallah Sahar A. 
Published: March 2023

AbstractIn this work, IN738 superalloy used previously in gas turbines was recycled and used as a working electrode for the electrooxidation of different fuels, namely ethylene glycol, ethanol, and urea. The electrocatalytic efficiency of the electrode was studied by cyclic voltammetry, chronoamperometry, and electrochemical impedance. Several kinetics parameters like diffusion coefficient, Tafel slope, rate constant, and activation energy were calculated. The modified electrode was characterized as received using XRD, SEM, and EDAX to elucidate the crystal structure and surface morphology before and after electrochemical oxidation. The anodic current densities of electrochemical oxidation of ethanol, ethylene glycol, and urea were 29, 17, and 12 mA.cm−2, respectively, in an alkaline solution at a potential of 0.6 V (vs. Ag/AgCl). The kinetic parameters like diffusion coefficients for ethanol, ethylene glycol, and urea were found to be 1.5 $$\times$$
×
10–6, 1.038 $$\times$$
×
10–6, and 0.64 $$\times$$
×
10–6 cm2 s−1, respectively. The charge transfer resistances were estimated for electrooxidation of different fuels by electrochemical impedance spectroscopy (EIS).
Graphical Abstract
“Gamma Irradiation Synthesis of Carboxymethyl Chitosan-Nanoclay Hydrogel for the Removal of Cr(VI) and Pb(II) from Aqueous Media”
Authors: El-Sayed Abdel-Raouf Manar , Kamal Rasha S. , Hegazy Dalia E. , Sayed Asmaa 
Published: March 2023

AbstractHydrogel composites comprised of N,O carboxymethyl chitosan crosslinked with different weight ratios of acrylic acid and fabricated with nanoclay particle were prepared via gamma irradiation at 25 kGy irradiation dose. The prepared composites were coded as CsAA1Cl, CsAA2Cl and CsAA3Cl based on the weight ratio of acrylic acid to the chitosan derivative. The claimed hydrogels were characterized by FTIR, TGA and XRD. The TGA data implied that the incorporation of clay nanoparticles enhanced the thermal stability of the composites; the decomposition temperature increased up to 500 °C for CsAA3Cl. Three AFM outcomes were used to compare the surface features of the samples; topography, height and surface roughness. The topography data reveals that the nanoclay particles incorporated in CsAA3Cl are intercalated and exfoliated. Then, the optimized sorbent (CsAA3Cl) was investigated as green sorbents for chromium (VI) and lead (II). The data revealed that CsAA3Cl displayed maximum removal performance towards both lead and chromium with removal efficiencies 125 mg/g and 205 mg/g respectively at the optimum application conditions within 90 min only. Also, it was found that the optimum pH value was 9 for chromium and 8 for lead. The data proved that the adsorption of both cations followed pseudo-first order kinetic model. The prepared composites showed acceptable metal uptake capacity at three successive cycles.Graphical Abstract
Mini-αA-Crystallin Stifled Melittin-Induced Haemolysis and Lymphocyte Lysis
Authors: Tender Tenzin , Rahangdale Rakesh Ravishankar , Shaik Mohammad Fayaz , Nampoothiri Madhavan , Sharma Krishna , Hariharapura Raghu Chandrashekar 
Published: March 2023

AbstractMelittin, the most potent pharmacological ingredient of honey bee venom, induces haemolysis, lymphocyte lysis, long-term pain, localised inflammation, and hyperalgesia. In this study, efforts were made to subdue the melittin’s ill effects using a chaperone peptide called ‘mini-αA-crystallin’ (MAC) derived from eye lens αA-crystallin. Haemolytic test on human red blood cells, percentage viability, and DNA diffusion assay on Human peripheral blood lymphocytes (HPBLs) were performed with melittin in the presence or absence of MAC. Propidium iodide and Annexin V-FITC dual staining were performed to analyse quantitative levels of necrotic and apoptotic induction by melittin in the presence or absence of MAC on HPBLs using a flow cytometer. A computational study to find out the interactions between MAC and melittin was undertaken by modelling the structure of MAC using a PEP-FOLD server. The result showed that MAC inhibited melittin-induced lysis in nucleated (lymphocytes) and enucleated (RBC) cells. Flow cytometric analysis revealed a substantial increase in the necrotic and late apoptotic cells after treating HPBLs with melittin (4 µg/ml) for 24 h. Treatment with MAC at a 2:1 molar ratio prevented HPBLs from developing melittin-induced necrosis and late apoptosis. In the docking study, hydrogen, van der Waals, π-π stacking, and salt bridges were observed between the MAC and melittin complex, confirming a strong interaction between them. The MAC-melittin complex was stable during molecular dynamics simulation. These findings may be beneficial in developing a medication for treating severe cases of honeybee stings.
Paternalistic persuasion: are doctors paternalistic when persuading patients, and how does persuasion differ from convincing and recommending?
Authors: Fleisje Anniken 
Published: March 2023

AbstractIn contemporary paternalism literature, persuasion is commonly not considered paternalistic. Moreover, paternalism is typically understood to be problematic either because it is seen as coercive, or because of the insult of the paternalist considering herself superior. In this paper, I argue that doctors who persuade patients act paternalistically. Specifically, I argue that trying to persuade a patient (here understood as aiming for the patient to consent to a certain treatment, although he prefers not to) should be differentiated from trying to convince him (here understood as aiming for the patient to want the treatment) and recommending (the doctor merely providing her professional opinion). These three forms of influence are illustrated by summaries of video-recorded hospital encounters. While convincing and recommending are generally not paternalistic, I argue that persuasion is what I call communicative paternalism and that it is problematic for two reasons. First, the patient’s preferences are dismissed as unimportant. Second, the patient might wind up undergoing treatment against his preferences. This does not mean that persuasion always should be avoided, but it should not be undertaken lightly, and doctors should be aware of the fine line between non-paternalism and paternalism. The fact that my analysis of paternalism differs from traditional accounts does not imply that I deem these to be wrong, but rather that paternalism should be considered as a more multi-faceted concept than previous accounts allow for.
Investigation of morphological, structural and electronic transformation of PVDF and ZnO/rGO/PVDF hybrid membranes
Authors: Omar Amina , Gomaa Islam , Mohamed Omar A. , Magdy Hager , Kalloub Hassan Saeed , Hamza Mohamed H. , Mohamed Tarek M. , Rabee Maisara M. , Tareq Nada , Hesham Haity , Abdallah Tamer , Elhaes Hanan , Ibrahim Medhat A. 
Published: March 2023

Abstract
Synergistic doping of 2-D Material ZnO nanosheets and reduced graphene oxide (rGO) of Polyvinylidene fluoride (PVDF), PVDF/ZnO, and PVDF/ZnO/rGO Hybrid membranes simply by solution casting technique for raising electronically favored β-phase ratio. Rietveld refinement X-ray diffraction technique, FTIR, Microscopic investigation, SEM, and density-functional theory (DFT) calculations were employed to unravel the atomistic origin of negative piezoelectricity, and increasing reasons for total dipole moment, electrostatic potential and bandgap energy of PVDF hybrid membranes, which arises from the sizeable displacive instability of two-dimensional material coupled with its reduced lattice dimensionality.
Female urethroplasty with dorsal onlay buccal mucosal graft: a single institution experience
Authors: Higgins Margaret M. , Wengryn Derek , Koslov David , Oliver Janine , Flynn Brian J. 
Published: March 2023

Abstract
Purpose
Female urethral stricture disease is frequently unrecognized or misdiagnosed, with controversy in the literature regarding the definition of strictures and approach to management. The purpose of this study is to report our institutional experience with female urethroplasty and add our experience to the growing body of research.

Methods
We performed a retrospective review of patients undergoing female urethroplasty with dorsal onlay BMG at the University of Colorado between March 2015 and December 2021 performed by two surgeons (BF and JO). The primary outcome measure was surgical success, defined as no stricture recurrence. The secondary outcome measure was the incidence of de novo urinary incontinence.

Results
23 patients were included in our data analysis. The median duration of lower urinary tract symptoms prior to urethroplasty was 16 years. 87% had undergone previous dilations. At a median follow-up of 12.2 months (range 1–81 months), four patients required a secondary procedure for obstruction with an overall success rate of 83%. One patient developed de novo stress urinary incontinence and one patient developed urge urinary incontinence. Subgroup analysis was performed comparing the patients that developed stricture recurrence (N = 4) to those that did not (N = 19). Those with stricture recurrence had a longer duration of symptoms and more dilations prior to urethroplasty.

Conclusion
Female urethroplasty with BMG is effective at treating female urethral stricture disease, with excellent outcomes at over a year of follow-up and minimal risk of stress incontinence postoperatively.
Determination of the Modulus of Elasticity by Bending Tests of Specimens with Nonuniform Cross Section
Authors: Gebhardt M. , Steinke H. , Slowik V. 
Published: March 2023

Abstract
Background
Bending tests offer technical advantages when material testing is performed to determine the modulus of elasticity. In biomechanical studies, beam-like cortical bone specimens subjected to flexural loading are usually characterized by nonuniform cross-sectional properties along the beam axis and a comparatively large spatial variation of the local material properties.

Objective
A suitable evaluation method for determining the average modulus of elasticity within the volume of beam-like specimens with nonuniform cross section was to be identified.

Methods
A total of 138 samples of human pelvic cortical bone were extracted and tested under flexural loading. Different methods, all based on the linear-elastic flexural theory of beams, were applied to determine the average modulus of elasticity on the basis of measured deformations, and the results were compared. Some of these methods utilized the measured midspan deflection, and others used the elastic curve obtained by digital image correlation.

Results
The results showed that it was not appropriate to determine the average modulus of elasticity from only the measured midspan deflection. The consideration of deflections at multiple points along the beam axis is recommended.

Conclusions
An evaluation method based on the fitting of the analytically determined elastic curve of the beam with its nonuniform cross-sectional properties to the measured deflections is considered the most appropriate method for determining the average modulus of elasticity of the specimen.
Deliberating a Sustainable Welfare–Work Nexus
Authors: Lee Jayeon , Koch Max , Alkan-Olsson Johanna 
Published: March 2023

AbstractVery few countries have managed to decouple economic growth from resource use and greenhouse gas emissions in absolute terms and at rates to meet the climate targets of the Paris Agreement. To achieve this, technological solutions would need to be combined with sufficiency-oriented policies in a postgrowth context. This paper develops policy ideas for a sustainable welfare–work nexus via citizen engagement and examines the level of democratic support for such ideas. Theoretically, it employs “sustainable welfare” to understand welfare and wellbeing within planetary and social limits. The paper first sketches the welfare–work nexus as developed in the postwar circumstances in Western Europe, highlighting that this model was at no point in time ecologically generalizable to the rest of the world, and then briefly reviews the existing debate on sustainable welfare. The empirical analyses start with qualitative data from 11 deliberative forums on sustainable needs satisfaction, with emphasis on policies targeted at respecting the upper and lower boundaries of a “safe and just operating space” for economic and social development. The qualitative data are then triangulated with quantitative data from a representative survey, which was constructed based on the policy suggestions from the forums, hence allowing for an exploration of their popularity in the Swedish population as a whole. We find a considerable gap between the far-reaching policy measures that forum participants consider necessary and the measures that the general public in Sweden are prepared to support, especially when it comes to policies targeting maximum levels of needs satisfaction.