bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Por que o seu ‘caderninho’ está cheio de escritas?”
Authors: Silva Anna Líssia da , Haddad Lenira 
Published: March 2023

Este artigo está inserido no contexto de uma tese de doutorado, cujo objetivo foi mapear a produção de pesquisas com crianças acerca de seus dizeres sobre questões relacionadas ao campo das diferenças. Na tese foram mapeados 323 os trabalhos dentro do campo das diferenças realizados em contextos de Educação Infantil. Dentre eles, foram selecionados 14 trabalhos que se denominaram pesquisas com crianças. Neste artigo, são analisadas as discursividades das pesquisadoras sobre pesquisas com crianças, metodologias e questões éticas que envolvem a participação das crianças. Também são destacadas as múltiplas formas e gestos de estar presente nas pesquisas que as crianças empreenderam em um movimento de ativo e criativo. A contribuição das produções analisadas indica que as pesquisas que abrem espaço para uma participação ativa das crianças, com a construção de espaços mais democráticos e sensíveis às vozes infantis, produzem saberes que possibilitam repensar os modos de produzir conhecimento sobre a vida das crianças e suas formas de ser e estar no mundo.
Palavras-chave: Pesquisa com crianças. Participação infantil. Crianças pequenas.
Health Economic Evaluations for Alzheimer’s Disease: Pathophysiology, Diagnosis and Pharmacological Approaches
Authors: Raj Rahul , Paul Prolay , Motwani Yogesh , Sinwal Aashutosh , Ishu  
Published: March 2023

Alzheimer's disease (AD) was first described by Alois Alzheimer in 1907 as a slowly progressing form of dementia that affects cognition, behavior, and functional status. It may be identified by the extracellular amyloid b (Ab) plaques as well as neurofibrillary tangle (NFT) deposits that are seen inside the neurons. Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) are the two main categories that form the base of AD presentation. EOAD is a condition that develops before the age of 65 and is linked to Mendelian inheritance, which results in a mutation in the genes APP, PSEN1, or PSEN2. So it is familial AD. While LOAD occur after age 65 years of age and, it is not related to a genetic cause. So it is sporadic AD. To assess and monitor the rate and pattern of cognitive loss, screening measures like the MMSE and the Montreal Cognitive Examination are utilized. Clinical biomarker testing is now available to assist physicians in determining the the presence and severity of AD pathologic alterations, as well as their lasting effects. Fibrillar (plaque) amyloid is detectable on PET. Despite the fact that AD is a public health issue, only two pharmaceutical classes—antagonists of N-methyl d-aspartate (NMDA) and inhibitors of the cholinesterase enzyme (naturally occurring, synthetic, and hybrid variants)—are allowed to be practiced to treat AD. AD is brought on by a decrease in the synthesis of acetylcholine (Ach) Increasing acetylcholine levels by decreasing acetylcholinesterase is one of the therapeutic interventions that enhances neuronal cells and cognitive function. Tacrine was the first cholinesterase inhibitor drug authorized by the FDA to be used for the treatment of AD.
Studies on Flowering Characteristics and Floral Morphology of Some Jamun Genotypes (Syzygium cuminii Skeels) under Semi-arid Lateritic Belt of West Bengal, India
Authors: Halder Agniva , Deb Prahlad 
Published: March 2023

A study was conducted to find out the variability of flowering behaviour and floral morphology of randomly selected 10 jamun genotypes (Syzygium cuminii Skeels) from 3 diferent districts namely Bankura, Purulia and Paschim Bardhaman under semi-arid lateritic belt of West Bengal during the year 2022. Only a single plant was considered for a single accession which was taken under the study. The selection was done on random basis. Significant variation has been observed among the genotypes for the flowering behaviour as well as morphological characters of flowers. Month of panicle emergence among the selected genotypes ranged from 1st week of March to last week of March. Time taken for bud development was observed 21 (days from panicle emergence) from three accessions like JA 9 was shortest among 10 jamun accessions studied. Longest time for bud development was observed in JA 4 (38 days). Duration of flowering was highest of 39 days in genotype JA 6 followed by 35 days in JA 10and 34 days in JA 4. The length of panicle was recorded longest from JA 1 (13.08 cm) and shortest in JA 2 (6.73 cm). Highest flower length was measured from JA 2 (26.39 mm) and lowest from JA 8 (8.31). Maximum number of branchlets per panicle was recorded from accessions like JA 1 (15.02) and it was least in JA 8 (7.39). Maximum number of flowers per branchlets was observed from JA 7 (12.07) followed by JA 4 (11.09). Number of stamens per flower varied between 58.04 and 67.07. The flower colour of all accessions was light yellow except JA 3(pale green). On the basis of this significant findings it can be conclude that the genotype JA 1 has most earliest flowering and biggest size flower from JA 2.
Collagen Hydrogel Containing Polyethylenimine‐Gold Nanoparticles for Drug Release and Enhanced Beating Properties of Engineered Cardiac Tissues
Authors: Roshanbinfar Kaveh , Kolesnik‐Gray Maria , Angeloni Miriam , Schruefer Stefan , Fiedler Maren , Schubert Dirk W. , Ferrazzi Fulvia , Krstic Vojislav , Engel Felix B. 
Published: March 2023

AbstractCardiac tissue engineering is a promising strategy to prevent heart failure. However, several issues remain unsolved, including efficient electrical coupling and incorporating factors to enhance tissue maturation and vascularization. Herein, a biohybrid hydrogel that enhances beating properties of engineered cardiac tissues and allows drug release concurrently is developed. Gold nanoparticles (AuNPs) with different sizes (18–241 nm) and surface charges (33.9–55.4 mV) are synthesized by reducing gold (III) chloride trihydrate using branched polyethyleneimine (bPEI). These nanoparticles increase gel stiffness from ≈91 to ≈146 kPa, enhance electrical conductivity of collagen hydrogels from ≈40 to 49–68 mS cm−1, and allow slow and steady release of loaded drugs. Engineered cardiac tissues based on bPEI‐AuNP‐collagen hydrogels and either primary or human induced pluripotent stem cell (hiPSC)‐derived cardiomyocytes show enhanced beating properties. hiPSC‐derived cardiomyocytes exhibit more aligned and wider sarcomeres in bPEI‐AuNP‐collagen hydrogels compared to collagen hydrogels. Furthermore, the presence of bPEI‐AuNPs result in advanced electrical coupling evidenced by synchronous and homogenous calcium flux throughout the tissue. RNA‐seq analyses are in agreement with these observations. Collectively, this data demonstrate the potential of bPEI‐AuNP‐collagen hydrogels to improve tissue engineering approaches to prevent heart failure and possibly treat diseases of other electrically sensitive tissues.
All Knitted and Integrated Soft Wearable of High Stretchability and Sensitivity for Continuous Monitoring of Human Joint Motion
Authors: Gupta Ujjaval , Lau Jun Liang , Chia Pei Zhi , Tan Ying Yi , Ahmed Alvee , Tan Ngiap Chuan , Soh Gim Song , Low Hong Yee 
Published: March 2023

AbstractE‐textiles have recently gained significant traction in the development of soft wearables for healthcare applications. However, there have been limited works on wearable e‐textiles with embedded stretchable circuits. Here, stretchable conductive knits with tuneable macroscopic electrical and mechanical properties are developed by varying the yarn combination and the arrangement of stitch types at the meso‐scale. Highly extensible piezoresistive strain sensors are designed (>120% strain) with high sensitivity (gauge factor 8.47) and durability (>100,000 cycles), interconnects (>140% strain) and resistors (>250% strain), optimally arranged to form a highly stretchable sensing circuit. The wearable is knitted with a computer numerical control (CNC) knitting machine that offers a cost effective and scalable fabrication method with minimal post‐processing. The real‐time data from the wearable is transmitted wirelessly using a custom designed circuit board. In this work, an all knitted and fully integrated soft wearable is demonstrated for wireless and continuous real‐time sensing of knee joint motion of multiple subjects performing various activities of daily living.
Large Scale BN‐perovskite Nanocomposite Aerogel Scintillator for Thermal Neutron Detection
Authors: Li Pei , Cheng Wei , Zhou Yifan , Zhao Dong , Liu Jun , Li Lingxi , Ouyang Xiaoping , Liu Bo , Jia Wenbao , Xu Qiang , Ostrikov Kostya (Ken) 
Published: March 2023

AbstractState‐of‐the‐art thermal neutron scintillation detectors rely on rare isotopes for neutron capture, lack stability and scalability of solid‐state scintillation devices, and poorly discriminate between the neutron and gamma rays. The boron nitride (BN)‐CsPbBr3perovskite nanocomposite aerogel scintillator enables discriminative detection of thermal neutrons, features the largest known size (9 cm across), the lowest density (0.17 g cm−3) among the existing scintillation materials, high BN (50%) perovskite (1%) contents, high optical transparency (85%), and excellent radiation stability. The new detection mechanism relies on thermal neutron capture by10B and effective energy transfer from the charged particles to visible‐range scintillation photons between the densely packed BN and CsPbBr3nanocrystals. Low density minimizes the gamma ray response. The neutrons and gamma rays are discriminated by complete decoupling of the respective single pulses in time and intensity. These outcomes open new avenues for neutron detection in resource exploration, clean energy, environmental, aerospace, and homeland security applications.
Ultralong Room‐Temperature Phosphorescence from Organic–Inorganic Hybrid Perovskitoid Based on Metal‐Organic Complex Component
Authors: Wang Zheng , Zhang Xiao‐Yu , Mo Jun‐Ting , Su Cheng‐Yong , Pan Mei 
Published: March 2023

AbstractOrganic–inorganic hybrid perovskite or perovskitoid phosphorescent materials have aroused extensive research interests due to their applications in organic light emitting diodes, anti‐counterfeiting, display, and other fields. Herein, a new strategy is proposed, employing metal‐organic complex (MOC) cations as the organic components, which can increase the spin–orbit coupling (SOC) and intersystem crossing (ISC) efficiencies of the organic units, and hybrid with inorganic parts to form a novel type MOC–inorganic composed perovskitoid. In detail, a lead‐free MOC–inorganic perovskitoid material, named P‐Cl, is synthesized by self‐assembly of preassembled MOC from metallized crown ethers with inorganic cadmium halide component. In the solid state, the assembled perovskitoid exhibits a tunable fluorescence color from blue to green, during which a cold white light emission is achieved. Interestingly, after removal of the radiation source, the perovskitoid still emits a bright and color‐tunable long persistent luminescence (LPL) from cyan to green. Single‐crystal X‐ray diffraction analysis and theoretical calculations reveal that the bright LPL of P‐Cl arises from the improvement of the metal‐organic part to increase the SOC and the interlocking of metal halogenated layers to inhibit the nonradiative transition. The proposed strategy not only broadens the range of organic–inorganic perovskitoid hybrid materials but also facilitates the design of multifunctional LPL materials.
Self‐Curable Synaptic Ferroelectric FET Arrays for Neuromorphic Convolutional Neural Network
Authors: Shin Wonjun , Im Jiyong , Koo Ryun‐Han , Kim Jaehyeon , Kwon Ki‐Ryun , Kwon Dongseok , Kim Jae‐Joon , Lee Jong‐Ho , Kwon Daewoong 
Published: March 2023

AbstractWith the recently increasing prevalence of deep learning, both academia and industry exhibit substantial interest in neuromorphic computing, which mimics the functional and structural features of the human brain. To realize neuromorphic computing, an energy‐efficient and reliable artificial synapse must be developed. In this study, the synaptic ferroelectric field‐effect‐transistor (FeFET) array is fabricated as a component of a neuromorphic convolutional neural network. Beyond the single transistor level, the long‐term potentiation and depression of synaptic weights are achieved at the array level, and a successful program‐inhibiting operation is demonstrated in the synaptic array, achieving a learning accuracy of 79.84% on the Canadian Institute for Advanced Research (CIFAR)‐10 dataset. Furthermore, an efficient self‐curing method is proposed to improve the endurance of the FeFET array by tenfold, utilizing the punch‐through current inherent to the device. Low‐frequency noise spectroscopy is employed to quantitatively evaluate the curing efficiency of the proposed self‐curing method. The results of this study provide a method to fabricate and operate reliable synaptic FeFET arrays, thereby paving the way for further development of ferroelectric‐based neuromorphic computing.
Manufactured doubt and the EPA 2020 chrysotile asbestos risk assessment
Authors: Dement John M. , Loomis Dana 
Published: March 2023

AbstractWhile all forms of asbestos have been determined to be carcinogenic to humans by the International Agency for Research on Cancer (IARC) as well as other authoritative bodies, the relative carcinogenic potency of chrysotile continues to be argued, largely in the context of toxic tort litigation. Relatively few epidemiologic studies have investigated only a single form of asbestos; however, one study that included an asbestos textile plant located in Marshville, North Carolina that processed chrysotile asbestos was used by the United States Environmental Protection Agency (EPA) in 2020 to help inform the agency's chrysotile asbestos risk assessment. During the EPA proceedings toxic tort defense consultants submitted comments to the EPA docket and made public presentations asserting that the Marshville plant had processed amphibole asbestos types and should not be used for the chrysotile risk assessment. A detailed evaluation of defense consultant assertions and supporting information and a full assessment of the available information concerning asbestos types used at the Marshville plant was undertaken. The preponderance of evidence continues to support the conclusion that neither amosite nor crocidolite were likely to have been processed in the Marshville textile plant. Defense consultants' assertions about chrysotile use are not supported by the preponderance of evidence and constitute an example of manipulation of information to cast uncertainty and doubt rather than to seek truth and contribute to the body of scientific evidence.
Adapting in the Arctic II: Upper limb diaphyseal robusticity and habitual activity in Late Holocene hunter‐gatherers from Alaska
Authors: Temple Daniel H. , Rosa Emily , Hunt David R. , Ruff Christopher B. 
Published: March 2023

AbstractObjectivesThis study compares humeral diaphyseal robusticity and asymmetry between Late Holocene hunter‐gatherers from Alaska with the goal of reconstructing habitual activity in relation to culture and environment.Materials and MethodsAncestral remains from four geographic regions of Alaska were divided into five site groups defined by subsistence strategies and technology: Aleutian Islands, Coastal Bay, Far North Coastal, Inland/Riverine, and Tikeraq. Mid‐distal humeral diaphyseal robusticity was quantified using cross‐sectional geometric properties standardized by estimated body mass and bone length.ResultsHumeral strength and bilateral asymmetry were greatest in Aleutian Island males, moderate in Far North Coastal and Tikeraq males, and reduced in Inland/Riverine males. Left‐biased directional asymmetry and reduced humeral strength were found in Coastal Bay males. Aleutian Island males had relatively mediolaterally strengthened humeri compared with other groups. Aleutian Island females had elevated humeral strength, while humeral asymmetry among females was moderate and did not vary between groups. Humeri were relatively round among Aleutian Island and Tikeraq females and anteroposteriorly (A‐P) strengthened among Coastal Bay, Far North Coastal, and Inland/Riverine females.ConclusionsThese results suggest elevated humeral strength and asymmetry in males that engaged in rowing and unimanual projectile hunting, while reduced humeral strength and asymmetry may reflect bow‐and‐arrow or ensnarement technologies. Left‐biased humeral asymmetry may be associated with net‐fishing. Humeral strength and asymmetry are consistent with select instances of unimanual projectile hunting in females, while differences in humeral A‐P/mediolateral strength may reflect variation in butchery and processing of prey versus rowing and throwing behaviors.
Sequence mining yields 18 phloretin C‐glycosyltransferases from plants for the efficient biocatalytic synthesis of nothofagin and phloretin‐di‐C‐glycoside
Authors: Putkaradze Natalia , Gala Valeria Della , Vaitkus Dovydas , Teze David , Welner Ditte Hededam 
Published: March 2023

AbstractC‐glycosyltransferases (C‐GTs) offer selective and efficient synthesis of natural product C‐glycosides under mild reaction conditions. In contrast, the chemical synthesis of these C‐glycosides is challenging and environmentally harmful. The rare occurrence of C‐glycosylated compounds in Nature, despite their stability, suggests that their biosynthetic enzymes, C‐GTs, might be scarce. Indeed, the number of characterized C‐GTs is remarkably lower than O‐GTs. Therefore, discovery efforts are crucial for expanding our knowledge of these enzymes and their efficient application in biocatalytic processes. This study aimed to identify new C‐GTs based on their primary sequence. 18 new C‐GTs were discovered, 10 of which yielded full conversion of phloretin to its glucosides. Phloretin is a dihydrochalcone natural product, with its mono‐C‐glucoside, nothofagin, having various health‐promoting effects. Several of these enzymes enabled highly selective production of either nothofagin (UGT708A60 and UGT708F2) or phloretin‐di‐C‐glycoside (UGT708D9 and UGT708B8). Molecular docking simulations, based on structural models of selected enzymes, showed productive binding modes for the best phloretin C‐GTs, UGT708F2 and UGT708A60. Moreover, we characterized UGT708A60 as a highly efficient phloretin mono‐C glycosyltransferase (kcat = 2.97 s‒1, KM = 0.1 μM) active in non‐buffered, dilute sodium hydroxide (0.1–1 mM). We further investigated UGT708A60 as an efficient biocatalyst for the bioproduction of nothofagin.
Dried blood spots for doping controls—Development of a comprehensive initial testing procedure with fully automated sample preparation
Authors: Garzinsky Ann‐Marie , Thomas Andreas , Guddat Sven , Görgens Christian , Dib Josef , Thevis Mario 
Published: March 2023

AbstractCurrently, primarily urine, whole blood and serum samples are analyzed for doping‐relevant substances in professional sports, but recently dried blood spots (DBS) have been introduced as complementary matrix, offering advantageous features, e.g. a minimally invasive sampling procedure. In order to cope with the increased application of DBS, a comprehensive initial testing procedure (ITP) was developed, optimized and validated, comprising a total of 233 substances representing all groups on the World Anti‐Doping Agency's (WADA's) Prohibited List. The sample preparation was conducted by employing a fully automated system using an efficient flow‐through extraction of a 4 mm diameter spot followed by LC–HRMS/MS analysis. The procedure was successfully validated in terms of selectivity, limit of detection, reproducibility, carryover and robustness with respect to an alternative manual sample preparation, an alternative dried blood collection device and the sample extract stability, and was thus found to meet the required criteria of the relevant guidelines published by WADA for routine application. As a proof‐of‐concept, DBS samples were analyzed after the administration of the glucocorticoids prednisone and dexamethasone, as well as the stimulant pseudoephedrine and the beta‐blocker propranolol. All substances were detected in post‐administration samples for at least 4 h and up to 24 h after intake, depending on the collection time period, using the developed testing procedure. In particular, for substances that are only banned in‐competition, data obtained from DBS samples can be useful for the interpretation of adverse analytical findings. In conclusion, the developed ITP accounts for the anticipated increasing relevance of DBS in anti‐doping analysis in the future and provides a foundation for optimized approaches for specific substance classes.
A multivalent Plasmodium falciparum circumsporozoite protein‐based nanoparticle malaria vaccine elicits a robust and durable antibody response against the junctional epitope and the major repeats
Authors: Pendyala Geetanjali , Calvo‐Calle J. Mauricio , Moreno Alberto , Kane Ravi S. 
Published: March 2023

AbstractPlasmodium falciparum (Pf) malaria continues to cause considerable morbidity and mortality worldwide. The circumsporozoite protein (CSP) is a particularly attractive candidate for designing vaccines that target sporozoites—the first vertebrate stage in a malaria infection. Current PfCSP‐based vaccines, however, do not include epitopes that have recently been shown to be the target of potent neutralizing antibodies. We report the design of a SpyCatcher‐mi3‐nanoparticle‐based vaccine presenting multiple copies of a chimeric PfCSP (cPfCSP) antigen that incorporates these important “T1/junctional” epitopes as well as a reduced number of (NANP)n repeats. cPfCSP‐SpyCatcher‐mi3 was immunogenic in mice eliciting high and durable IgG antibody levels as well as a balanced antibody response against the T1/junctional region and the (NANP)n repeats. Notably, the antibody concentration elicited by immunization was significantly greater than the reported protective threshold defined in a murine challenge model. Refocusing the immune response toward functionally relevant subdominant epitopes to induce a more balanced and durable immune response may enable the design of a more effective second generation PfCSP‐based vaccine.
Matrix‐Metalloproteinase Inhibitory Study of Novel Tetrahydroisoquinoline‐4‐carboxylates: Design, Synthesis, and Molecular Docking Studies
Authors: Devappa Satyanarayan Nayak , Kammathalli Siddappa Manjunatha , Rahman Abdul , Belur Ningegowda Nippu , Sherapura Ankith , Siddesh B. M. , Prabhakar B. T. 
Published: March 2023

AbstractThe design, molecular docking, synthesis and structure‐activity relationship (SAR) of a series of novel methyl 1‐oxo‐2‐(propan‐2‐yl)‐3‐(pyridin‐3‐yl)‐1,2,3,4‐tetrahydroisoquinoline‐4‐carboxylates, were investigated for antiproliferative and cytotoxic studies by screening against cancer cell lines of different origin by MTT, LDH and Trypan Blue Assay. Irrespective of cell lines, among the synthesized nonpeptido‐mimetic analogs 5a–e, 5c has executed potent bio‐potency with IC50 value of 7.00 to 7.21 μM, which further expressed in‐vivo anti‐tumor activity against murine T‐cell lymphoma cell lines (Daltons Lymphoma‐DLA) by regressing tumor growth. The formation of neovessels from the vasculogenesis was diminished reflecting the antitumor activity. The neovessel formation is directly relied on expression of matrix meteloproteases (MMP's) level which was drastically reduced by 5c treatment as evaluated by immonoblot assays. This is further supported by in‐silico ADMET studies performed by ACD I‐Lab 2.0 were in agreement with Lipinski rule of five. Reporting results were assessed as a positive parameter for further validation of the compound for therapeutic potential of cancer by 5c for preclinical studies in near future.