bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les femmes et la chanson au Québec : quels cadrages ? pour quelles histoires ?
Authors: Savoie Chantal 
Published: April 2023

Depuis la réflexion amorcée dans l’article « Les femmes et la chanson au Québec », paru dans le collectif Écouter la chanson (Savoie 2009), j’ai entrepris de m’intéresser autrement à l’histoire de la place de femmes dans l’histoire de la chanson au Québec. L’objectif était alors de recadrer mes objets d’étude afin d’en arriver à cerner le(s) rôle(s) joué(s) par les femmes dans l’évolution des pratiques chansonnières au fil du temps, et les stratégies à mettre en oeuvre pour produire une histoire de leurs pratiques et apports plutôt qu’une histoire de leur invisibilisation progressive. En effet, malgré l’accès à des ressources de plus en plus vastes et diversifiées, notre façon même de concevoir les corpus et les approches que nous adoptons continuent, consciemment ou non, à prioriser deux dimensions de l’histoire de la chanson : celle de la production (évolution de la technologie en général et des médias en particulier, maisons de disques, catalogues, partitions, étiquettes, etc.) et celle du « texte » (contenu textuel et musical, interprétation). Or, l’ébranlement disciplinaire provoqué par l’effet conjugué de l’École des Annales, des études culturelles et des gender studies, entre autres, a contribué à favoriser les approches systémiques, voir poly-systémiques, pour analyser la culture (comme production, forme, médiation, appropriation, etc.). S’il faut certes de nouvelles sources pour écrire une nouvelle histoire, le regard que nous posons sur ces données doit lui aussi se renouveler, s’assumer et s’expliciter. C’est dans cette perspective que j’ai réalisé un vaste chantier d’étude sur la chanson des années 1940 en abordant la chanson d’un double point de vue féminin qui s’écarte volontairement de la stricte production musicale, en priorisant les goûts du public féminin et les représentations de comportements liés au genre féminin dans les chansons.
Les oiseaux de l’île d’Anticosti : nouvelle liste systématique, particularités et perspectives
Authors: Drolet Bruno , Lepage Christine , Rail Jean-François , Aubry Yves 
Published: April 2023

Cet article présente une mise à jour de la liste des oiseaux de l’île d’Anticosti (Québec, Canada) depuis la première compilation réalisée par Henri Ouellet en 1969. L’avifaune de l’île, au 4 novembre 2022, compte 261 espèces, dont 74 nouvelles espèces et comparativement à la liste de Ouellet, la majorité de celles-ci sont des espèces inusitées. Les canards de mer fréquentent en grand nombre les eaux côtières de l’île d’Anticosti au moment des migrations, de la mue et de l’hivernage. Les oiseaux marins coloniaux nichent dans des falaises bien protégées, mais leurs populations ont grandement diminué au fil des ans, sauf dans le cas du guillemot à miroir. Les oiseaux de rivage, dont les données sont rares pour l’île, sont plus présents lors de la migration postnuptiale. Les oiseaux terrestres se distinguent de ceux des régions voisines, sous l’effet de l’introduction du cerf de Virginie et possiblement en raison de l’absence de l’écureuil roux sur l’île. En outre, l’abondance du bec-croisé des sapins est à souligner. Enfin, presque la moitié des oiseaux de l’île d’Anticosti ont un statut d’espèces prioritaires à des fins de conservation, de sorte que l’avifaune de l’île est un élément incontournable des futures stratégies de gestion et d’aménagement du territoire.
Histoire du canal Saint-Georges (Port-Menier, île d’Anticosti) et perspectives : la valorisation du patrimoine culturel par l’aménagement fluvial
Authors: Gariépy-Girouard Étienne , Buffin-Bélanger Thomas , Savard Manon , Biron Pascale M. 
Published: April 2023

Le canal Saint-Georges est un cours d’eau d’origine anthropique construit en 1898 lors de l’installation d’Henri Menier sur l’île d’Anticosti. Depuis, il a été aménagé pour l’adapter à différents usages. À partir de la fin des années 1970, les processus fluviaux ont graduellement façonné le cours d’eau, entraînant une morphologie plus naturelle. Un projet d’aménagement du canal Saint-Georges et de ses habitats pour le poisson, réalisé de 2019 à 2022, a aussi mené au démantèlement d’un barrage, à la stabilisation de berges ainsi qu’à des aménagements fauniques. Cet article présente les trajectoires historiques anthropique et naturelle du canal dans le but de mettre en lumière leurs interactions. L’évolution des usages du canal Saint-Georges comprend 3 périodes distinctes, qui ont chacune influencé les processus fluviaux ainsi que la morphologie résultante. Cette évolution à la fois anthropique et naturelle du canal Saint-Georges est caractéristique de plusieurs cours d’eau aménagés, ce qui représente à la fois des possibilités et des défis de gestion. Ce cas montre l’importance de considérer la particularité hybride de ces cours d’eau dans leur restauration et leur aménagement. À l’avenir, cela pourrait mener à mieux respecter leur fonctionnement potentiel ainsi qu’à mettre davantage en valeur leur patrimoine culturel.
Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis
Authors: Hiddingh Sanne , Pandit Aridaman , Verhagen Fleurieke , Rijken Rianne , Servaas Nila Hendrika , Wichers Rina CGK , Loon Ninette H ten Dam-van , Imhof Saskia M , Radstake Timothy RDJ , de Boer Joke H , Kuiper Jonas JW 
Published: April 2023

Background:Type I interferons (IFNs) promote the expansion of subsets of CD1c+ conventional dendritic cells (CD1c+ DCs), but the molecular basis of CD1c+ DCs involvement in conditions not associated without elevated type I IFNs remains unclear.Methods:We analyzed CD1c+ DCs from two cohorts of non-infectious uveitis patients and healthy donors using RNA-sequencing followed by high-dimensional flow cytometry to characterize the CD1c+ DC populations.Results:We report that the CD1c+ DCs pool from patients with non-infectious uveitis is skewed toward a gene module with the chemokine receptor CX3CR1 as the key hub gene. We confirmed these results in an independent case–control cohort and show that the disease-associated gene module is not mediated by type I IFNs. An analysis of peripheral blood using flow cytometry revealed that CX3CR1+ DC3s were diminished, whereas CX3CR1− DC3s were not. Stimulated CX3CR1+ DC3s secrete high levels of inflammatory cytokines, including TNF-alpha, and CX3CR1+ DC3 like cells can be detected in inflamed eyes of patients.Conclusions:These results show that CX3CR1+ DC3s are implicated in non-infectious uveitis and can secrete proinflammatory mediators implicated in its pathophysiology.Funding:The presented work is supported by UitZicht (project number #2014-4, #2019-10, and #2021-4). The funders had no role in the design, execution, interpretation, or writing of the study.
Effectiveness of real-time classroom interactive competition on academic performance: a systematic review and meta-analysis
Authors: Jurado-Castro Jose Manuel , Vargas-Molina Salvador , Gómez-Urquiza Jose L. , Benítez-Porres Javier 
Published: April 2023

In recent years, different tools have been introduced into the educational landscape to promote active participation and interaction between students and teachers through personal response systems. The evolution of this methodology has allowed students to participate in real-time by answering questions posed. Previous reviews on the effectiveness of real-time classroom interactive competition (RCIC) on academic performance have been performed; however, this research was based only on Kahoot, without considering other RCIC tools or programs. In addition, the RCIC effectiveness at different educational levels and its effect according to the duration of the intervention has not been meta-analytically analyzed until to date. The aim of this meta-analysis was to analyze the RCIC effectiveness in improving academic performance. A search focused on studies from the educational field published from 2010 until September 2022 was performed. Experimental studies with objective and valid data (scores based on tests or exams) were included. From a total of 397 studies considered potentially eligible, 23 studies met the inclusion criteria. The sample was n = 1,877 for the experimental group and n = 1,765 for the control group with an academic improvement in favor to experimental group (MD 7.34; CI [5.31–9.43]; p < 0.001). There was also significant improvement in academic performance when analyzing different educational levels and different tools. In addition, both short-term interventions (two weeks or less in duration) and long-term (from two weeks to one year in duration) were effective. Therefore, RCIC interventions seem to be an effective strategy to improve academic performance.
Otimização da desidratação osmótica da mangaba (Hancornia speciosa) como alternativa para a sua preservação
Authors: De Souza Michael Ruan Silveira , Da Silva Larissa de Sousa , Chaves Rosane Patrícia Ferreira , Pombo Joseane Cristina Pinheiro , Moraes Jaqueline de Fátima Cabral , Souza Tammy Sara Oliveira Iuco , Cardoso Raiane Vieira , De Araújo Adriano Lucena 
Published: April 2023

A mangaba (Hancornia speciosa) é um fruto característico da região Nordeste do Brasil e apresenta excelentes atributos sensoriais e nutritivos, sendo também utilizado na industrialização, sob a forma de doces, geleias, compotas, vinho, vinagre, suco e sorvete. Esta pesquisa objetiva otimizar o processo de desidratação osmótica (DO) da mangaba ao analisar a influência de diferentes concentrações de solução osmótica (C) em diferentes períodos de imersão (T) do fruto, sobre as respostas perda de água (PA) e ganho de sólidos (GS), a fim de estabelecer condições ótimas para a melhor conservação do fruto. Para o desenvolvimento da pesquisa, os frutos foram adquiridos no estádio de maturação maduro de um fornecedor local da região de Salvaterra (Pará) e transportados para o Laboratório de Tecnologia de Alimentos (UEPA – Campus Salvaterra), onde se iniciaram os procedimentos de desidratação osmótica. A relação amostra/solução foi de 1 g do fruto para cada 5 mL da solução osmótica, sendo a umidade determinada antes e após o processo. Para avaliar os efeitos das variáveis independentes (C e T), foi utilizado um delineamento composto central rotacional (DCCR) do tipo 22, totalizando 11 ensaios experimentais. As análises estatísticas dos coeficientes de regressão e a análise de variância (ANOVA) foram utilizados para avaliar o grau de ajuste dos modelos propostos aos dados experimentais. As superfícies de respostas apontaram que maiores concentrações de solução osmótica (C) e maiores tempos de imersão (T) favoreceram as maiores PA e GS no fruto. Os resultados obtidos para a otimização simultânea das respostas definiu como condições ótimas para o processo: C = 56 % e T = 55,18 min, visando a maximização da PA e minimização do GS.
Risk of Recall Associated With Modifications to High-risk Medical Devices Approved Through US Food and Drug Administration Supplements
Authors: Dubin Jonathan R. , Enriquez Jonathan R. , Cheng An-Lin , Campbell Hunter , Cil Akin 
Published: April 2023

ImportanceHigh-risk medical devices approved by the US Food and Drug Administration (FDA) can undergo modifications to their original premarket approval (PMA) via 1 of 5 types of supplements. Only panel track supplements (approximately 1%) require clinical data for approval. The association between device modifications and risk to patient safety has not previously been analyzed.ObjectiveTo determine the association between PMA supplements and the risk of any device recall and high-risk (class 1) recall.Design, Setting, and ParticipantsIn this cohort study, the FDA database was queried for original devices approved via PMA from January 1, 2008, through December 31, 2019. Supplement and recall data were obtained for these devices from January 1, 2008, through December 31, 2021, giving a minimum 2-year follow-up after initial approval. Data were analyzed from July 6 to August 6, 2022. Retrospective, time-to-event analysis investigated the association between the number and type of supplements and risk of recall.ExposuresSupplements submitted by manufacturers for FDA approval to modify devices.Main Outcomes and MeasuresA mixed-effects Cox proportional hazards regression model with frailty terms was used, modeling device recall as an outcome variable during the observation period. A second model was performed for class 1 (high-risk) recall. Explanatory variables are the number of supplements, number of panel track supplements, and cardiovascular devices. Multivariable analysis was performed to identify independent risk factors for recall with hazard ratios (HRs) as the main end point.ResultsA total of 373 original PMA devices with 10 776 associated supplements were included in the analysis. A median 2.5 (IQR, 1.2-5.0) supplements per device were approved annually. Cardiovascular devices contributed 138 supplements (37.0%), followed by microbiology with 45 (12.1%). No other specialty contributed more than 10%. Multivariable analysis demonstrated that each increase of 1 supplement per year was associated with increased risk of recall (HR, 1.28 [95% CI, 1.15-1.44]; P &amp;lt; .001). For class 1 recall, increased number of supplements (HR, 1.32 [95% CI, 1.06-1.64]; P = .01) and cardiovascular vsnoncardiovascular classification of devices (HR, 3.51 [95% CI, 1.15-10.72]; P = .03) were significantly associated with an increased risk of recall.Conclusions and RelevanceThe findings of this cohort study suggest that PMA supplements are associated with an approximately 30% increased risk of any recall and class 1 recall. The FDA processes for approving modifications to high-risk medical devices should be reevaluated to optimize patient safety and public health.
Evaluation of Preferred Language and Timing of COVID-19 Vaccine Uptake and Disease Outcomes
Authors: Quadri Nasreen S. , Knowlton Greg , Vazquez Benitez Gabriela , Ehresmann Kirsten R. , LaFrance Amy B. , DeFor Terese A. , Smith M. Kumi , Mann Erin M. , Alpern Jonathan D. , Stauffer William M. 
Published: April 2023

ImportanceBeyond traditional race and ethnicity demographic characteristics, additional discrete data variables are needed for informed health interventions in the US.ObjectiveTo examine whether COVID-19 vaccine uptake patterns and associated disease outcomes differ among language preference groups.Design, Setting, and ParticipantsA cohort study of 851 410 individuals aged 18 years or older in a large multispecialty health system in Minnesota and western Wisconsin was conducted between December 15, 2020, and March 31, 2022.ExposureSelf-identified language preference and limited English proficiency (LEP) as measured by interpreter need were used to create subgroups using US census categories and attention to capture languages known to represent refugee groups.Main Outcomes and MeasuresThe primary outcome was COVID-19 vaccination uptake rates and time to first vaccine. Secondary outcomes were rates of COVID-19–associated hospitalization and death.ResultsMost of the 851 410 participants (women, 493 910 [58.0%]; median age, 29 [IQR, 35-64] years) were US-born English speakers; 7.5% were born in other countries, 4.0% had a language preference other than English (LPOE), and 3.0% indicated LEP as measured by interpreter need. Marked temporal clusters were observed for COVID-19 vaccination uptake, hospitalizations, and deaths associated with primary series vaccine eligibility, booster availability, and COVID-19 variants. Delayed first-dose vaccine was observed with LPOE (hazard ratio [HR], 0.83; 95% CI, 0.82-0.84) and interpreter need (HR, 0.81; 95% CI, 0.80-0.82) compared with those with English language preference and proficiency. Patients with LPOE were approximately twice as likely to be hospitalized (rate ratio [RR], 1.85; 95% CI, 1.63-2.08) or die (RR, 2.13; 95% CI, 1.65-2.69). Patients with LEP experienced even higher rates of hospitalization (RR, 1.98; 95% CI, 1.73-2.25) and COVID-19–associated death (RR, 2.32; 95% CI, 1.79-2.95). Outcomes varied for individual language preference groups.Conclusions and RelevanceIn this study, delayed time to first-dose vaccine was associated with increased COVID-19 hospitalization and death rates for specific LPOE and LEP groups. The findings suggest that data collection of language preference and interpreter need provides actionable health intervention information. Standardized system-level data collection, including at a national level, may improve efficient identification of social groups with disproportionate health disparities and provide key information on improving health equity in the US.
Effort-Cost Decision-making Among Individuals With Schizophrenia
Authors: Blouzard Elodie , Pouchon Arnaud , Polosan Mircea , Bastin Julien , Dondé Clément 
Published: April 2023

ImportanceMotivational impairments in schizophrenia are by definition associated with poor outcome. It is postulated that the reduction of goal-directed behavior arises from abnormal trade-offs between rewards and efforts.ObjectiveTo examine whether schizophrenia is associated with impairments in effort-cost decision-making.Data SourcesFor this systematic review and meta-analysis, the PubMed, ScienceDirect, PsycINFO, Embase, and ClinicalTrials.gov databases were searched from inception to July 2022 for studies that investigated effort-cost decision-making in schizophrenia. Search terms included effort, cost, and schizophrenia.Study SelectionConsensual criteria for inclusion were peer-reviewed studies published in English that used a computerized effort-cost decision-making behavioral paradigm and compared individuals with schizophrenia with control individuals.Data Extraction and SynthesisThe Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guideline was used for abstracting data. Data were extracted independently by 2 authors and then pooled using random-effects sizes and bayesian approaches.Main Outcomes and MeasuresThe main outcomes were performance on effort-cost decision-making tasks requiring an effort-reward trade-off, measured by Hedges g effect size. Effects of moderators were tested with meta-regressions and subgroup analyses.ResultsTwenty studies involving 1503 participants were included: 837 individuals with schizophrenia (541 [64.6%] male; mean [SD] age, 35.89 [6.70] years) and 666 control individuals without schizophrenia (360 [54.1%] male; mean [SD] age, 34.16 [5.92] years). Participants with schizophrenia had significantly reduced willingness to expend effort for rewards compared with controls (k = 20; effect size, 0.43; 95% CI, 0.30-0.56; P &amp;lt; .001; I2 = 33.1%; Q test P = .08). The magnitude of the deficit was significantly greater for high-reward trials. The severity of negative symptoms was negatively associated with effort-cost decision-making (k = 8; effect size, −0.33; 95% CI, −0.50 to −0.15; P &amp;lt; .001), while participants with a high number of negative symptoms had a significantly larger impairment in effort-cost decision-making (k = 5; effect size, 0.47; 95% CI, 0.10-0.84; P = .01).Conclusions and RelevanceIn this systematic review and meta-analysis, schizophrenia was associated with deficits in effort allocation as indexed by effort-cost decision-making tasks. Understanding the cognitive and neurobiological mechanisms driving effort allocation impairments may assist in developing novel interventions.
Self‐configuring nnU‐Net for automatic delineation of the organs at risk and target in high‐dose rate cervical brachytherapy, a low/middle‐income country's experience
Authors: Duprez Didier , Trauernicht Christoph , Simonds Hannah , Williams O'Brian 
Published: April 2023

AbstractBackgroundThe high‐dose rate (HDR) brachytherapy treatment planning workflow for cervical cancer is a labor‐intensive, time‐consuming, and expertise‐driven process. These issues are amplified in low/middle‐income countries with large deficits in experienced healthcare professionals. Automation has the ability to substantially reduce bottlenecks in the planning process but often require a high level of expertise to develop.PurposeTo implement the out of the box self‐configuring nnU‐Net package for the auto‐segmentation of the organs at risk (OARs) and high‐risk CTV (HR CTV) for Ring‐Tandem (R‐T) HDR cervical brachytherapy treatment planning.MethodsThe computed tomography (CT) scans of 100 previously treated patients were used to train and test three different nnU‐Net configurations (2D, 3DFR, and 3DCasc). The performance of the models was evaluated by calculating the Sørensen‐dice similarity coefficient, Hausdorff distance (HD), 95th percentile Hausdorff distance, mean surface distance (MSD), and precision score for 20 test patients. The dosimetric accuracy between the manual and predicted contours was assessed by looking at the various dose volume histogram (DVH) parameters and volume differences. Three different radiation oncologists (ROs) scored the predicted bladder, rectum, and HR CTV contours generated by the best performing model. The manual contouring, prediction, and editing times were recorded.ResultsThe mean DSC, HD, HD95, MSD and precision scores for our best performing model (3DFR) were 0.92/7.5 mm/3.0 mm/ 0.8 mm/0.91 for the bladder, 0.84/13.8 mm/5.3 mm/1.4 mm/0.84 for the rectum, and 0.81/8.5 mm/6.0 mm/2.2 mm/0.80 for the HR CTV. Mean dose differences (D2cc/90%) and volume differences were 0.08 Gy/1.3 cm3 for the bladder, 0.02 Gy/0.7 cm3 for the rectum, and 0.33 Gy/1.5 cm3 for the HR CTV. On average, 65% of the generated contours were clinically acceptable, 33% requiring minor edits, 2% required major edits, and no contours were rejected. Average manual contouring time was 14.0 min, while the average prediction and editing times were 1.6 and 2.1 min, respectively.ConclusionOur best performing model (3DFR) provided fast accurate auto generated OARs and HR CTV contours with a large clinical acceptance rate.
Natural history and survival rate of familial amyloidosis with polyneuropathy: A nationwide databank
Authors: Tseng Wei‐Hsiang , Huang Han‐Wei , Li Chia‐Chun , Chang Chin‐Sung , Chan Wing P. , Lin Kong‐Pin , Wu Chih‐Hsing 
Published: April 2023

AbstractObjectiveHereditary amyloid transthyretin (ATTRv) amyloidosis with polyneuropathy, a rare autosomal‐dominant disease, has gained attention in recent years owing to treatment improvements. However, epidemiological real‐world mega database of nationwide natural history and survival rates, especially with the specific mutation of Ala97Ser, are limited.MethodsTaiwan National Health Insurance Research Database contains data from over 23 million individuals; Among them, 175 ATTRv amyloidosis patients validated by rare disease registry were enrolled. Multivariable Cox proportional hazard analyses were applied to investigate the association between baseline characteristics and all‐cause mortality.FindingsFrom 2008 to 2020, the annual incidence and prevalence rates of specific mutations (Ala97Ser) leading to ATTRv amyloidosis with polyneuropathy were 0.04–1.14 and 0.04–4.79 per million in Taiwan, respectively. In Taiwan, these patients exhibited male predominance with a mean age at validation of 62.75 years. At the 5th year after validation, patients exhibited a survival rate of approximately 50%, with higher mortality in male patients (hazard ratio [HR]: 2.22, 95% confidence interval [CI]: 1.15–4.31) and patients older at validation (HR: 1.10, 95% CI: 1.06–1.15). The two most common departments in outpatient were neurology and family medicine, and neurology and cardiology in inpatient. The three most common causes of death registered were unspecified amyloidosis (30.6%), organ‐limited amyloidosis (20.9%), and neuropathic heredofamilial amyloidosis (9.7%).InterpretationThe annual prevalence rate of specific mutation (Ala97Ser)‐dominant ATTRv amyloidosis with polyneuropathy in Taiwan is comparable to the mid‐ to high‐prevalence country level of the research by Schmidt et al. The extraordinarily high mortality, especially among patients older at validation, may reflect the inadequate awareness and the necessity of early intervention with novel disease‐modifying regimens.