bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a program director for osteopathic medical education to support osteopathic recognition at a training site with multiple programs
Authors: Eilerman Andrew , Porter Chas , Faherty Mallory , Zmuda Elizabeth 
Published: January 2025

Abstract

Context
With the advent of the Single Accreditation System (SAS) within the Accreditation Council for Graduate Medical Education (ACGME), few programs have achieved Osteopathic Recognition (OR) status to date. OR is an accreditation that graduate medical education (GME) programs can achieve to distinctly acknowledge the additional focus on osteopathic training. There is an effort by national osteopathic organizations to determine barriers for programs to achieve OR and what innovative methods might help overcome them. In identifying its own barriers, a central Ohio hospital created a unique Program Director for Osteopathic Medical Education (PDOME) role to assist its 10 programs in achieving OR.

Objectives
The objectives of this study were to determine the effect that a PDOME role has through measures of the numbers of programs achieving OR and standards met, as well as the perceived ‘helpfulness’ of the role based on surveys of program leadership.

Methods
Upon initiation of the PDOME in July 2021, the PDOME assessed applications, citations, and curriculums of the 10 hospital programs with varied OR status to help determine curricular goals. Additional osteopathic activities, evaluation tools and faculty development were subsequently offered based on this information and needs assessments of the programs. A survey was sent to all programs at intervals of 12 and 18 months after role inception to be utilized as process improvement. Comparisons were made between surveys, as well as between the total number of programs with continued OR status and the total OR requirements achieved before and after PDOME. A chi-square test (or Fisher’s exact test when the ‘n’ was too small) was utilized for significance, and the p value was set at 0.05.

Results
After the PDOME, there was a significant increase in the number of OR standards met across programs (p<0.001). Although not significant, the number of programs achieving continued OR increased from 4 to 8 (p=0.168). Due to many positive responses in both surveys, there was no significance between surveys in the “helpfulness” of PDOME; however, there was a significant increase in the number of respondents from 13/67 (or 19.4 %) to 32/67 (or 47.8 %) (p<0.001), indicating increased engagement among respondents.

Conclusions
This study suggests that a PDOME role in medical education may be well received and may assist GME programs in achieving OR. Implementation of a similar role elsewhere could help programs overcome barriers and stir growth in OR programs nationwide.
One Size Does Not Fit All: Cardiorespiratory Fitness Adaptations to Basic Military Training are Attenuated in Female Recruits and Recruits With High Baseline Fitness
Authors: Saner Nicholas J. , Kuang Jujiao , Cheng I-Ting , Drain Jace R. , Bishop David J. 
Published: January 2025

Abstract
Saner, NJ, Kuang, J, Cheng, I-T, Drain, JR, and Bishop, DJ. One size does not fit all: Cardiorespiratory fitness adaptations to basic military training are attenuated in female recruits and recruits with high baseline fitness. J Strength Cond Res 38(10): 1724–1731, 2024— A focus of basic military training (BMT) is to improve the physical fitness of recruits. However, significant individual variation in the response to BMT has been reported, and the prevalence of injury is high. This study investigated the relationship between baseline cardiorespiratory fitness (CRF), sex, and age to changes in CRF and musculoskeletal injury (MSKI) during BMT. Cardiorespiratory fitness and injury prevalence were prospectively assessed in a large mixed-sex cohort of Australian Army recruits (n = 1,581) undergoing 12 weeks of BMT. There was a significant group-level increase in estimated V̇o
2max during BMT (6.6 ± 7.9%, p < 0.001); however, there was significant individual variation in responses. Baseline CRF and sex were significant predictors (p < 0.001) of change in estimated V̇o
2max, but age was not (p = 0.115). Recruits within the 2 highest quintiles for baseline CRF improved estimated V̇o
2max significantly less than recruits in the lowest 3 quintiles (p < 0.001). Male recruits improved estimated V̇o
2max to a greater extent than female recruits (mean difference ± SD, 1.9 ± 0.2 mL·kg–1·min–1, p < 0.001), even when baseline fitness was accounted for. There were 153 recruits that reported 1 or more MSKI during BMT, and there was approximately 2.5-fold higher MSKI incidence in female recruits. Overall, we report that CRF improved during BMT and that baseline CRF and sex partially explain these improvements. However, female recruits demonstrated modest gains in CRF and were disproportionately injured when compared with male recruits. This highlights the need for ability-based training strategies to yield consistent improvements and reduce injury prevalence in military personnel.
Neural Dynamics of the Processing of Speech Features: Evidence for a Progression of Features from Acoustic to Sentential Processing
Authors: Karunathilake I.M Dushyanthi. , Brodbeck Christian , Bhattasali Shohini , Resnik Philip , Simon Jonathan Z. 
Published: January 2025

When we listen to speech, our brain’s neurophysiological responses “track” its acoustic features, but it is less well understood how these auditory responses are enhanced by linguistic content. Here, we recorded magnetoencephalography (MEG) responses while subjects of both sexes listened to four types of continuous-speech-like passages: speech-envelope modulated noise, English-like non-words, scrambled words, and a narrative passage. Temporal response function (TRF) analysis provides strong neural evidence for the emergent features of speech processing in cortex, from acoustics to higher-level linguistics, as incremental steps in neural speech processing. Critically, we show a stepwise hierarchical progression of progressively higher order features over time, reflected in both bottom-up (early) and top-down (late) processing stages. Linguistically driven top-down mechanisms take the form of late N400-like responses, suggesting a central role of predictive coding mechanisms at multiple levels. As expected, the neural processing of lower-level acoustic feature responses is bilateral or right lateralized, with left lateralization emerging only for lexical-semantic features. Finally, our results identify potential neural markers, linguistic level late responses, derived from TRF components modulated by linguistic content, suggesting that these markers are indicative of speechcomprehensionrather than mere speech perception.Significance StatementWe investigate neural processing mechanisms as speech evolves from acoustic signals to meaningful language, using stimuli ranging from without any linguistic information to fully well-formed linguistic content. Computational models based on speech and linguistic hierarchy reveal that cortical responses time-lock to emergent features from acoustics to linguistic processes at the sentence level, with increasing the semantic information in the acoustic input. Temporal response functions (TRFs) uncovered millisecond-level processing dynamics as speech and language stages unfold. Each speech feature undergoes early and late processing stages, with the former driven by bottom-up activation and the latter influenced by top-down mechanisms. These insights enhance our understanding of the hierarchical nature of auditory language processing.
Correction of clip thinking among pedagogical students in the process of solving practice-oriented tasks
Authors: Buzhinskaya N. V. , Vaseva E. S. , Meshkova I. V. , Shkabara I. E. 
Published: January 2025

Introduction. One of the characteristics of modern society is the emergence of a phenomenon known as clip thinking. The presence of clip thinking in a future teacher may hinder the development of competencies that are essential for professional success. Aim. The aim of this paper is to present a scheme for addressing a practice-oriented task, specifically designed to correct clip thinking in future teachers. Methodology and research methods. The methodological foundation of the study was based on system-activity, systemic, and practice-oriented approaches, which facilitated the identification of the characteristics of clip thinking. The study involved 250 undergraduate students from Nizhny Tagil Branch of the Russian State Vocational Pedagogical University. The authors employed the method described by S. D. Polyakov, L. A. Belozerova, and V. V. Vershinina, along with a questionnaire developed by the authors themselves. To confirm or validate the hypothesis of the study, a comparative analysis was conducted using the Student’s t-test. Results. A scheme has been proposed for addressing practice-oriented tasks that facilitate the integration of viewing information fragments related to future professional activities and their comprehension. The effectiveness of using practice-oriented tasks to correct students’ clip thinking has been demonstrated. The diagnostic tool “Clip-Integrity Thinking” (by S. D. Polyakov, L. A. Belozerova, V. V. Vershinina and colleagues) has been adapted to evaluate the level of clip thinking among students in higher education institutions. Scientific novelty. The results of the study enhance scientific understanding of how to address clip thinking and also consider its presence when developing strategies for training future teachers. Practical significance. The data obtained can be utilised to develop a methodology for training future teachers in the field of digital technologies, aimed at addressing the issue of clip thinking. The proposed assessments of clip thinking levels can be employed to identify the unique characteristics of each student and to construct individualised educational trajectories based on this information.
Mindfulness, Emotional Intelligence, and Gender as Predictors of Academic Motivation in High School Students
Authors: Askara Ghanisa Anggit , Putra Rahman Pranovri , Herwin Herwin , Rizky Deo Alfa 
Published: January 2025

Academic motivation plays a very important role in the student's learning process, influencing various aspects of development. This study aims to see academic motivation in students in terms of mindfulness, emotional intelligence, and gender. This study is a quantitative study with an ex-post facto approach using multiple linear regression tests and using independent sample T tests to compare academic motivation based on gender. The number of samples in the study was 375 high school students using simple random sampling techniques. The results of this study indicate that there is a significant positive influence between mindfulness and emotional intelligence on academic motivation with a significance value of .000 (<.05) and affects academic motivation by 69.0%. Comparison of academic motivation based on gender found that men are higher than women with a mean difference of 1.78 with a significance of .004 which shows a significant difference. This study shows that mindfulness and emotional intelligence are significant predictors of academic motivation in high school students. Mindfulness allows students to be more focused and aware of the learning process, thus reducing distractions and increasing academic engagement. Meanwhile, emotional intelligence helps students manage emotions, deal with academic stress, and build positive relationships, which in turn support motivation to learn.
The prevalence and risk factors among people with diabetes mellitus in a selected rural community of kerala
Authors: Jose Pinky , John Bindu , George Jincymol , Mathew Emil , Joseph Jishamol , Abhayan Manjima T , Joseph Jojia C 
Published: January 2025

The recent statistics of India in 2023 suggest a prevalence of 10.1 crores of diabetes in the community, with three in four adults with diabetes living in low- and middle-income countries, and half of them are unaware of their condition. This study aims to assess the prevalence of diabetes mellitus among people in a selected rural community and to identify the risk factors among people with diabetes mellitus.A quantitative research approach with a descriptive, cross-sectional study design was adopted. The participants were 824 adults, males, and females, aged above 21 years, and selected using a convenience sampling method. Data was collected from two selected wards of Athirampuzha panchayat, Kottayam, Kerala. Data were collected from a larger survey conducted in this area. The tool used was a structured questionnaire with three parts: a socio-demographic tool, lifestyle-related factors, and a specific part for collecting diabetes-related information. The results indicated that nearly 15.90% of the population had diabetes mellitus (n=131), and majority were above above 50 years. A majority of the diabetes-affected people were females (n 69, 52.67%), married (n= 104, 79.39%), unemployed (n =76, 58.02%), homemakers (n=72, 54.96%), and belonged to nuclear families (n=81, 61.83%). Most of them have been diagnosed with diabetes mellitus for the past 5-10 years and are on treatment with oral hypoglycemic agents (n=107, 81.68%). About 32% of them had familial risk factors (n=42). Among the comorbid conditions, 41.98% (n= 55) had hypertension. A majority of the participants were having a BMI above normal (51.15%, n-= 67, BMI=25.0 -29.9) and were following sedentary lifestyle habits (n=113, 86.26%). : The study highlight the importance of targeting the lifestyle risk factors for preventing diabetes mellitus in the community at an early stage.
Literackie realizmy przełomu wieków. Cz. II: Realizm histeryczny i David Foster Wallace
Authors: Woźniak Jarosław 
Published: January 2025

Niniejszy artykuł stanowi drugą część cyklu poświęconego literackim realizmom literackim przełomu XX i XXI wieku. Skupia się na realizmie histerycznym wyłaniającym się z literatury postmodernistycznej i ewoluującym w kierunku Nowej Szczerości. Nurt ten omawiany jest przede wszystkim na przykładzie twórczości Davida Fostera Wallace’a. Najpierw autor rekonstruuje koncepcję histerycznego realizmu, którą do krytyki literackiej wprowadził James Wood, ostro krytykując powieści zaliczone przez siebie w obręb tego nurtu. W kolejnych częściach autor stara się umiejscowić realizm histeryczny w relacji do poprzedzającej go literatury postmodernistycznej i wskazać na jakich podstawach, wbrew Woodowi, może zostać uznany za literaturę realistyczną.
Integrative multi-omics analysis for identifying novel therapeutic targets and predicting immunotherapy efficacy in lung adenocarcinoma
Authors: Chen Zilu , Mei Kun , Tan Foxing , Zhou YuHeng , Du Haolin , Wang Min , Gu Renjun , Huang Yan 
Published: January 2025

Aim: Lung adenocarcinoma (LUAD), the most prevalent subtype of non-small cell lung cancer (NSCLC), presents significant clinical challenges due to its high mortality and limited therapeutic options. The molecular heterogeneity and the development of therapeutic resistance further complicate treatment, underscoring the need for a more comprehensive understanding of its cellular and molecular characteristics. This study sought to delineate novel cellular subpopulations and molecular subtypes of LUAD, identify critical biomarkers, and explore potential therapeutic targets to enhance treatment efficacy and patient prognosis.
Methods: An integrative multi-omics approach was employed to incorporate single-cell RNA sequencing (scRNA-seq), bulk transcriptomic analysis, and genome-wide association study (GWAS) data from multiple LUAD patient cohorts. Advanced computational approaches, including Bayesian deconvolution and machine learning algorithms, were used to comprehensively characterize the tumor microenvironment, classify LUAD subtypes, and develop a robust prognostic model.
Results: Our analysis identified eleven distinct cellular subpopulations within LUAD, with epithelial cells predominating and exhibiting high mutation frequencies in Tumor Protein 53 (TP53) and Titin (TTN) genes. Two molecular subtypes of LUAD [consensus subtype (CS)1 and CS2] were identified, each showing distinct immune landscapes and clinical outcomes. The CS2 subtype, characterized by increased immune cell infiltration, demonstrated a more favorable prognosis and higher sensitivity to immunotherapy. Furthermore, a multi-omics-driven machine learning signature (MOMLS) identified ribonucleotide reductase M1 (RRM1) as a critical biomarker associated with chemotherapy response. Based on this model, several potential therapeutic agents targeting different subtypes were proposed.
Conclusion: This study presents a comprehensive multi-omics framework for understanding the molecular complexity of LUAD, providing insights into cellular heterogeneity, molecular subtypes, and potential therapeutic targets. Differential sensitivity to immunotherapy among various cellular subpopulations was identified, paving the way for future immunotherapy-focused research.
Development of a Chemosensor Based on Carbon Paste Electrode Modified with Saffron-Conjugated Silver Nanoparticles for the Sensitive and Selective Simultaneous Electroanalytical Detection of CD, Pb, Zn, Cu, and Cl in Soils and Plants
Authors: Girousi Stella , Keramari Vasiliki , Paraschi Ioanna , Karastogianni Sophia , Golia Evangelia 
Published: January 2025

A simple and easily applicable analytical method for the simultaneous determination of Cd2+, Pb2+, Zn2+, Cu2+, and Cl- applying a modified with saffron-conjugated silver nanoparticles (AgNPs@Sa) is being presented. The modified CPE was then used for the simultaneous determination of Cd2+, Pb2+, Zn2+, and Cu2+ as well as chloride ions in soil and plants. The comparative analysis demonstrated a significant enhancement in the applicability of the modified electrode through the incorporation of silver nanoparticles (AgNPs) at the carbon paste electrode (CPE) surface, leading to the development of a poly-Sa-CPE. This newly proposed method offers notably superior qualitative performance compared to other metal nanoparticle-based modifications reported in the literature. The accordingly modified electrode was successfully applied in the development of a chloride ion. A novel sensor, is being proposed, that makes possible the determination of heavy metals and chorides in the same solution, in soil and plant samples.
The enhanced sensitivity and selectivity of the poly-Sa-CPE system highlights its potential as a more effective alternative for heavy metal and chloride analysis, further demonstrating its advantages in electrochemical applications.
Optimization of Bio-lubricant Produced from Non-edible Jatropha curcas Seed Oil
Authors: Rockson-itiveh David Emoefe , Efih Alexander Oghenereke , Keke Mabel , Ozioko Fabian Chidiebere 
Published: January 2025

<p>This paper presents the production and optimization of a bio-lubricant derived from non-edible Jatropha plant seed oil. Plant oil-based lubricants offer significant environmental benefits and are derived from renewable sources, making them an attractive alternative to conventional lubricants. They provide a potential solution for sustainable and low-cost feedstock for fuel oil and its derivatives without competing with food uses, as Jatropha oil contains toxic esters unsuitable for human consumption. Jatropha seed oil was extracted using a Soxhlet apparatus fitted with a heating mantle. A total of 500 g of the extracted oil was esterified in a round-bottom flask glass reactor with 25 wt% methanol and 1.0 wt% H₂SO₄ as a catalyst, reducing free fatty acids (FFA) to approximately 1%. The esterified oil was then subjected to transesterification in a reactor preheated to 60°C. A mixture of 1.0 wt% NaOH and methanol at a 6:1 ratio was added while stirring at 300 rpm for a reaction time of 90 minutes. The transesterification process was optimized using a 23 response surface methodology (RSM) experimental design. This design evaluated the effects of temperature (112.16°C to 160.00°C), reaction time (1.81 to 5.00 hours), and catalyst concentration (0.73% to 1.73% w/w) at a constant mole ratio of JME to TMP of 3.9:1 under vacuum conditions. The results revealed that the optimal conditions for bio-lubricant synthesis were a temperature of 130°C, a reaction time of 3 hours, and a catalyst concentration of 0.8% w/w. A second-order quadratic model was developed to predict the yield of Jatropha curcas bio lubricant based on the process variables. The model predicted a yield of 88.74% with a desirability of 0.9739 and demonstrated a high coefficient of determination (R²) of 0.9739, indicating strong predictive accuracy</p><p> </p><p><strong>Keywords:</strong></p><p align="left">Bio-lubricant, Jatropha, Esterification, Seed Oil</p><p><strong><br /></strong></p>
Hubungan Status Gizi dengan Demam Neutropenia pada Anak dengan Leukemia Limfoblastik Akut
Authors: Nadela Dewi Bahari  , Pridania Vidya  , Muhammad Riza  
Published: January 2025

Pendahuluan: Leukemia Limfoblastik Akut adalah keganasan hematologi paling sering terjadi pada anak. Pengobatan utama LLA adalah kemoterapi. Demam neutropenia merupakan komplikasi umum dan dianggap keadaan darurat onkologis. Demam neutropenia dapat dipengaruhhi oleh jenis keganasan dan rejimen kemoterapi. Faktor risiko demam neutropenia adalah status gizi, usia, penyakit komorbid, kadar albumin, dan jenis kelamin. Terdapat perbedaan hasil penelitian sebelumnya mengenai hubungsan status gizi dengan demam neutropenia. Di Surakarta belum ada penelitian mengenai hubungan tersebut. Oleh karena itu, penelitian ini dilakukan untuk membuktikan apakah status gizi sebagai faktor risiko demam neutropenia LLA anak. Penelitian ini penting karena dapat menjadi deteksi dini demam neutropenia.
Metode: Penelitian observasional analitik dengan rancangan potong lintang. Sumber data penelitian adalah data sekunder dari rekam medis pasien LLA anak 0-18 tahun di RSUD Dr. Moewardi Surakarta dengan teknik simple random sampling. Data dianalis dengan uji chi square menggunakan SPSS.
Hasil: Hasil uji chi square didapatkan nilai p<0.001 yang artinya terdapat hubungan antara status gizi dengan demam neutropenia. Nilai OR=6.107 yang artinya status gizi buruk atau lebih memiliki risiko 6.107 kali mengalami demam neutropenia dibandingkan status gizi baik.
Kesimpulan: Terdapat hubungan antara status gizi dengan demam neutropenia pada LLA anak dengan status gizi buruk atau lebih memiliki risiko 6.107 kali mengalami demam neutropenia dibandingkan status gizi baik.
An analysis of the Kumaraswamy distribution for multi-objective probabilistic linear fractional programming problem
Authors: ALAMA HAMEDA MOHAMED , ALSHRANI MUSTAFA OMRAN 
Published: January 2025

Abstract

A technique for solving a multi-objective probabilistic linear fractional programming MOPLFP problem is presented, a Kumaraswamy distribution describes the parameters of the right-hand constraints. There is no direct solution to the MOPLFP problem. Three steps are needed to transform the proposed model into a known standard mathematical model. To illustrate the method, a numerical example and a practical example in the case of supply chain management are presented. The results indicate that the objective functions have dominant solutions.
AMS Subject Classiffcation: 90C15; 90C29; 90C32.