bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling the Intermittent Lava Lake Drops Occurring Between 2015 and 2021 at Nyiragongo Volcano
Authors: Walwer D. , Wauthier C. , Barrière J. , Smittarello D. , Smets B. , d’Oreye N. 
Published: April 2023

AbstractBetween 2015 and 2021, Nyiragongo's lava lake level experienced a linear increase punctuated by fast intermittent drops. These drops occurred synchronously to seismic swarm at approximately 15 km below the surface and extending laterally NE from the volcano. To interpret these lava lake level patterns in terms of reservoirs pressure evolution within Nyiragongo, we consider the following simplified plumbing system: a central reservoir is fed by a constant flux of magma, distributing the fluid up into the lava lake and laterally into a distal storage zone. Magma transport is driven by a pressure gradient between the magma storage bodies, accommodating influx and outflow of magma elastically, and the lava lake. Lateral transport at depth occurs through a hydraulic connection for which the flow resistance is coupled to the magma flux. When the right conditions are met, lateral magma transport occurs intermittently and triggers intermittent lava lake level drops matching the observations.
Characteristics of Storm Surge Events Along the North‐East Atlantic Coasts
Authors: Pineau‐Guillou Lucia , Delouis Jean‐Marc , Chapron Bertrand 
Published: April 2023

AbstractStorm surges are often characterized in terms of magnitude, duration and frequency. Here, we propose a novel statistical method to help characterize the full dynamics of storm surge events. The method, called ECHAR, is based on techniques already successfully applied in astrophysics. Analysis of 20 tide gauges in the North‐East Atlantic consistently reveals that storm surge events display two distinctive components, a slow‐time background Gaussian structure and a fast‐time Laplace structure. Each of these structures can be reduced to its duration and amplitude. For large events, occurring 5 times per winter, the slow‐time structure lasts around 16 days, varying from 9 days in the South to 45 days in the North (Baltic Sea), with almost the same amplitude at all the stations (around 0.17 m). The fast‐time structure lasts around 1.7 days at all the stations, but its amplitude greatly varies, from 0.1 m in the South to 1.6 m in the North Sea. The wind stress contributes mostly to the fast‐time component of the storm surge event, whereas the atmospheric pressure contributes to both components. The proposed ECHAR method, helping to characterize extreme events, can be applied anywhere else in the global ocean, for example, where tropical storm surges occur.
Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1
Authors: Fiskus Warren , Mill Christopher P. , Birdwell Christine , Davis John A. , Das Kaberi , Boettcher Steffen , Kadia Tapan M. , DiNardo Courtney D. , Takahashi Koichi , Loghavi Sanam , Soth Michael J. , Heffernan Tim , McGeehan Gerard M. , Ruan Xinjia , Su Xiaoping , Vakoc Christopher R. , Daver Naval , Bhalla Kapil N. 
Published: April 2023

AbstractMonotherapy with Menin inhibitor (MI), e.g., SNDX-5613, induces clinical remissions in patients with relapsed/refractory AML harboring MLL1-r or mtNPM1, but most patients either fail to respond or eventually relapse. Utilizing single-cell RNA-Seq, ChiP-Seq, ATAC-Seq, RNA-Seq, RPPA, and mass cytometry (CyTOF) analyses, present pre-clinical studies elucidate gene-expression correlates of MI efficacy in AML cells harboring MLL1-r or mtNPM1. Notably, MI-mediated genome-wide, concordant, log2 fold-perturbations in ATAC-Seq and RNA-Seq peaks were observed at the loci of MLL-FP target genes, with upregulation of mRNAs associated with AML differentiation. MI treatment also reduced the number of AML cells expressing the stem/progenitor cell signature. A protein domain-focused CRISPR-Cas9 screen in MLL1-r AML cells identified targetable co-dependencies with MI treatment, including BRD4, EP300, MOZ and KDM1A. Consistent with this, in vitro co-treatment with MI and BET, MOZ, LSD1 or CBP/p300 inhibitor induced synergistic loss of viability of AML cells with MLL1-r or mtNPM1. Co-treatment with MI and BET or CBP/p300 inhibitor also exerted significantly superior in vivo efficacy in xenograft models of AML with MLL1-r. These findings highlight novel, MI-based combinations that could prevent escape of AML stem/progenitor cells following MI monotherapy, which is responsible for therapy-refractory AML relapse.
Heterogeneity of cancer-associated fibroblasts in head and neck squamous cell carcinoma: opportunities and challenges
Authors: Hu Chen , Zhang Yifan , Wu Chunping , Huang Qiang 
Published: April 2023

AbstractHead and neck squamous cell carcinoma (HNSCC) is among the most severe and complex malignant diseases with a high level of heterogeneity and, as a result, a wide range of therapeutic responses, regardless of clinical stage. Tumor progression depends on ongoing co-evolution and cross-talk with the tumor microenvironment (TME). In particular, cancer-associated fibroblasts (CAFs), embedded in the extracellular matrix (ECM), induce tumor growth and survival by interacting with tumor cells. Origin of CAFs is quite varied, and the activation patterns of CAFs are also heterogeneous. Crucially, the heterogeneity of CAFs appears to play a key role in ongoing tumor expansion, including facilitating proliferation, enhancing angiogenesis and invasion, and promoting therapy resistance, through the production of cytokines, chemokines, and other tumor-promotive molecules in the TME. This review describes the various origin and heterogeneous activation mechanisms of CAFs, and biological heterogeneity of CAFs in HNSCC is also included. Moreover, we have highlighted versatility of CAFs heterogeneity in HNSCC progression, and have discussed different tumor-promotive functions of CAFs respectively. In the future, it is a promising strategy for the therapy of HNSCC that specifically targeting tumor-promoting CAF subsets or the tumor-promoting functional targets of CAFs.
Interfacial engineered superelastic metal-organic framework aerogels with van-der-Waals barrier channels for nerve agents decomposition
Authors: Yan Zishuo , Liu Xiaoyan , Ding Bin , Yu Jianyong , Si Yang 
Published: April 2023

AbstractChemical warfare agents (CWAs) significantly threaten human peace and global security. Most personal protective equipment (PPE) deployed to prevent exposure to CWAs is generally devoid of self-detoxifying activity. Here we report the spatial rearrangement of metal-organic frameworks (MOFs) into superelastic lamellar-structured aerogels based on a ceramic network-assisted interfacial engineering protocol. The optimized aerogels exhibit efficient adsorption and decomposition performance against CWAs either in liquid or aerosol forms (half-life of 5.29 min, dynamic breakthrough extent of 400 L g−1) due to the preserved MOF structure, van-der-Waals barrier channels, minimized diffusion resistance (~41% reduction), and stability over a thousand compressions. The successful construction of the attractive materials offers fascinating perspectives on the development of field-deployable, real-time detoxifying, and structurally adaptable PPE that could be served as outdoor emergency life-saving devices against CWAs threats. This work also provides a guiding toolbox for incorporating other critical adsorbents into the accessible 3D matrix with enhanced gas transport properties.
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma
Authors: Kuang Chunmei , Xia Meijuan , An Gang , Liu CuiCui , Hu Cong , Zhang Jingyu , Liu Zhenhao , Meng Bin , Su Pei , Xia Jiliang , Guo Jiaojiao , Zhu Yinghong , Liu Xing , Wu Xuan , Shen Yi , Feng Xiangling , He Yanjuan , Li Jian , Qiu Lugui , Zhou Jiaxi , Zhou Wen 
Published: April 2023

AbstractThrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM. In addition, we identify serine, which is released from MM cells into the bone marrow microenvironment, as a key metabolic factor that suppresses megakaryopoiesis and thrombopoiesis. The impact of excessive serine on thrombocytopenia is mainly mediated through the suppression of megakaryocyte (MK) differentiation. Extrinsic serine is transported into MKs through SLC38A1 and downregulates SVIL via SAM-mediated tri-methylation of H3K9, ultimately leading to the impairment of megakaryopoiesis. Inhibition of serine utilization or treatment with TPO enhances megakaryopoiesis and thrombopoiesis and suppresses MM progression. Together, we identify serine as a key metabolic regulator of thrombocytopenia, unveil molecular mechanisms governing MM progression, and provide potential therapeutic strategies for treating MM patients by targeting thrombocytopenia.
Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer
Authors: Palakurthi Bhavana , Fross Shaneann R. , Guldner Ian H. , Aleksandrovic Emilija , Liu Xiyu , Martino Anna K. , Wang Qingfei , Neff Ryan A. , Golomb Samantha M. , Lewis Cheryl , Peng Yan , Howe Erin N. , Zhang Siyuan 
Published: April 2023

AbstractChemotherapy prior to immune checkpoint blockade (ICB) treatment appears to improve ICB efficacy but resistance to ICB remains a clinical challenge and is attributed to highly plastic myeloid cells associating with the tumor immune microenvironment (TIME). Here we show by CITE-seq single-cell transcriptomic and trajectory analyses that neoadjuvant low-dose metronomic chemotherapy (MCT) leads to a characteristic co-evolution of divergent myeloid cell subsets in female triple-negative breast cancer (TNBC). Specifically, we identify that the proportion of CXCL16 + myeloid cells increase and a high STAT1 regulon activity distinguishes Programmed Death Ligand 1 (PD-L1) expressing immature myeloid cells. Chemical inhibition of STAT1 signaling in MCT-primed breast cancer sensitizes TNBC to ICB treatment, which underscores the STAT1’s role in modulating TIME. In summary, we leverage single-cell analyses to dissect the cellular dynamics in the tumor microenvironment (TME) following neoadjuvant chemotherapy and provide a pre-clinical rationale for modulating STAT1 in combination with anti-PD-1 for TNBC patients.
Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form
Authors: Werner Michael S. , Loschko Tobias , King Thomas , Reich Shelley , Theska Tobias , Franz-Wachtel Mirita , Macek Boris , Sommer Ralf J. 
Published: April 2023

AbstractDevelopment can be altered to match phenotypes with the environment, and the genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated. Yet, the rules that govern environmental sensitivity vs. invariant development, and potential epigenetic memory, remain unknown. Here, we show that plasticity of nematode mouth forms is determined by histone 4 lysine 5 and 12 acetylation (H4K5/12ac). Acetylation in early larval stages provides a permissive chromatin state, which is susceptible to induction during the critical window of environmental sensitivity. As development proceeds deacetylation shuts off switch gene expression to end the critical period. Inhibiting deacetylase enzymes leads to fixation of prior developmental trajectories, demonstrating that histone modifications in juveniles can carry environmental information to adults. Finally, we provide evidence that this regulation was derived from an ancient mechanism of licensing developmental speed. Altogether, our results show that H4K5/12ac enables epigenetic regulation of developmental plasticity that can be stored and erased by acetylation and deacetylation, respectively.
Condensation and asymmetric amplification of chirality in achiral molecules adsorbed on an achiral surface
Authors: Liu Huiru , Li Heping , He Yu , Cheng Peng , Zhang Yi-Qi , Feng Baojie , Li Hui , Wu Kehui , Chen Lan 
Published: April 2023

AbstractThe origin of homochirality in nature is an important but open question. Here, we demonstrate a simple organizational chiral system constructed by achiral carbon monoxide (CO) molecules adsorbed on an achiral Au(111) substrate. Combining scanning tunneling microscope (STM) measurements with density-functional-theory (DFT) calculations, two dissymmetric cluster phases consisting of chiral CO heptamers are revealed. By applied high bias voltage, the stable racemic cluster phase can be transformed into a metastable uniform phase consisting of CO monomers. Further, during the recondensation of a cluster phase after lowering down bias voltage, an enantiomeric excess and its chiral amplification occur, resulting in a homochirality. Such asymmetry amplification is found to be both kinetically feasible and thermodynamically favorable. Our observations provide insight into the physicochemical origin of homochirality through surface adsorption and suggest a general phenomenon that can influence enantioselective chemical processes such as chiral separations and heterogeneous asymmetric catalysis.
Modelling seasonal household variation in harvested rainwater availability: a case study in Siaya County, Kenya
Authors: Yu Weiyu , Wanza Peggy , Kwoba Emmah , Mwangi Thumbi , Okotto-Okotto Joseph , Trajano Gomes da Silva Diogo , Wright Jim A. 
Published: April 2023

AbstractRainwater harvesting reliability, the proportion of days annually when rainwater demand is fully met, is challenging to estimate from cross-sectional household surveys that underpin international monitoring. This study investigated the use of a modelling approach that integrates household surveys with gridded precipitation data to evaluate rainwater harvesting reliability, using two local-scale household surveys in rural Siaya County, Kenya as an illustrative case study. We interviewed 234 households, administering a standard questionnaire that also identified the source of household stored drinking water. Logistic mixed effects models estimated stored rainwater availability from household and climatological variables, with random effects accounting for unobserved heterogeneity. Household rainwater availability was significantly associated with seasonality, storage capacity, and access to alternative improved water sources. Most households (95.1%) that consumed rainwater faced insufficient supply of rainwater available for potable needs throughout the year, with intermittencies during the short rains for most households with alternative improved sources. Although not significant, stored rainwater lasts longer for households whose only improved water source was rainwater (301.8 ± 40.2 days) compared to those having multiple improved sources (144.4 ± 63.7 days). Such modelling analysis could enable rainwater harvesting reliability estimation, and thereby national/international monitoring and targeted follow-up fieldwork to support rainwater harvesting.
Stress testing ΛCDM with high-redshift galaxy candidates
Authors: Boylan-Kolchin Michael 
Published: April 2023

AbstractEarly data from the James Webb Space Telescope (JWST) have revealed a bevy of high-redshift galaxy candidates with unexpectedly high stellar masses. An immediate concern is the consistency of these candidates with galaxy formation in the standard ΛCDM cosmological model, wherein the stellar mass (M⋆) of a galaxy is limited by the available baryonic reservoir of its host dark matter halo. The mass function of dark matter haloes therefore imposes an absolute upper limit on the number density n (>M⋆, z) and stellar mass density ρ⋆ (>M⋆, z) of galaxies more massive than M⋆ at any epoch z. Here I show that the most massive galaxy candidates in JWST observations at z ≈ 7–10 lie at the very edge of these limits, indicating an important unresolved issue with the properties of galaxies derived from the observations, how galaxies form at early times in ΛCDM or within this standard cosmology itself.
Initial treatment response and short-term mortality of spontaneous bacterial peritonitis in cirrhotic patients with hepatocellular carcinoma
Authors: Lee Chang Hun , Kang Hye Jin , Yu Song Yi , Seo Seung Young , Kim Seong Hun , Kim Sang Wook , Lee Seung Ok , Lee Soo Teik , Kim In Hee 
Published: April 2023

AbstractThis study aimed to investigate the initial treatment response and short-term mortality of spontaneous bacterial peritonitis (SBP) in cirrhotic patients with hepatocellular carcinoma (HCC) compared with those without HCC. A total of 245 patients with liver cirrhosis diagnosed with SBP between January 2004 and December 2020 were included. Of these, 107 (43.7%) were diagnosed with HCC. Overall, the rates of initial treatment failure, 7-day and 30-day mortality were 91 (37.1%), 42 (17.1%), and 89 (36.3%), respectively. While the baseline CTP score, MELD score, culture-positive rate, and rates of antibiotic resistance did not differ between both groups, patients with HCC had a higher rate of initial treatment failure than those without HCC patients (52.3% vs. 25.4%, P < 0.001). Similarly, 30-day mortality was also significantly higher in patients with HCC (53.3% vs. 23.2%, P < 0.001). In the multivariate analysis, HCC, renal impairment, CTP grade C, and antibiotic resistance were independent factors for initial treatment failure. Furthermore, HCC, hepatic encephalopathy, MELD score, and initial treatment failure were independent risk factors for 30-day mortality, with statistically significant poor survival outcomes in patients with HCC (P < 0.001). In conclusion, HCC is an independent risk factor for initial treatment failure and high short-term mortality in patients with cirrhosis with SBP. It has been suggested that more attentive therapeutic strategies are required to improve the prognosis of patients with HCC and SBP.
Tug of War games and PDEs on graphs with applications in image and high dimensional data processing
Authors: Ennaji Hamza , Quéau Yvain , Elmoataz Abderrahim 
Published: April 2023

AbstractThe aim of this note is to revisit the connections between some stochastic games, namely Tug-of-War games, and a class of nonlocal PDEs on graphs. We consider a general formulation of Tug-of-War games which is shown to be related to many classical PDEs in the continuous setting. We transcribe these equations on graphs using ad hoc differential operators and we show that it covers several nonlocal PDEs on graphs such as $$\infty $$
∞
-Laplacian, game p-Laplacian and the eikonal equation. This unifying mathematical framework allows us to easily design simple algorithms to solve several inverse problems in imaging and data science, with a particular focus on cultural heritage and medical imaging.
Increasing cell culture density during a developmental window prevents fated rod precursors derailment toward hybrid rod-glia cells
Authors: Barravecchia Ivana , De Cesari Chiara , Guadagni Viviana , Signore Giovanni , Bertolini Edoardo , Giannelli Serena Gea , Scebba Francesca , Martini Davide , Pè Mario Enrico , Broccoli Vania , Andreazzoli Massimiliano , Angeloni Debora , Demontis Gian Carlo 
Published: April 2023

AbstractIn proliferating multipotent retinal progenitors, transcription factors dynamics set the fate of postmitotic daughter cells, but postmitotic cell fate plasticity driven by extrinsic factors remains controversial. Transcriptome analysis reveals the concurrent expression by postmitotic rod precursors of genes critical for the Müller glia cell fate, which are rarely generated from terminally-dividing progenitors as a pair with rod precursors. By combining gene expression and functional characterisation in single cultured rod precursors, we identified a time-restricted window where increasing cell culture density switches off the expression of genes critical for Müller glial cells. Intriguingly, rod precursors in low cell culture density maintain the expression of genes of rod and glial cell fate and develop a mixed rod/Muller glial cells electrophysiological fingerprint, revealing rods derailment toward a hybrid rod-glial phenotype. The notion of cell culture density as an extrinsic factor critical for preventing rod-fated cells diversion toward a hybrid cell state may explain the occurrence of hybrid rod/MG cells in the adult retina and provide a strategy to improve engraftment yield in regenerative approaches to retinal degenerative disease by stabilising the fate of grafted rod precursors.
Plant chemical variation mediates soil bacterial community composition
Authors: Buchkowski Robert W. , Benedek Klára , Bálint János , Molnár Attila , Felföldi Tamás , Fazakas Csaba , Schmitz Oswald J. , Balog Adalbert 
Published: April 2023

AbstractAn important challenge in the study of ecosystem function is resolving how plant antiherbivore chemical defence expression may influence plant-associated microbes, and nutrient release. We report on a factorial experiment that explores a mechanism underlying this interplay using individuals of the perennial plant Tansy that vary genotypically in the chemical content of their antiherbivore defenses (chemotypes). We assessed to what extent soil and its associated microbial community versus chemotype-specific litter determined the composition of the soil microbial community. Microbial diversity profiles revealed sporadic effects of chemotype litter and soil combinations. Soil source and litter type both explained the microbial communities decomposing the litter with soil source having a more important effect. Some microbial taxa are related to particular chemotypes, and thus intra-specific chemical variation of a single plant chemotype can shape the litter microbial community. But we found that ultimately the effect of fresh litter inputs from a chemotype appeared to act secondary as a filter on the composition of the microbial community, with the primary factor being the existing microbial community in the soil.
Maternal autistic traits and antenatal pain by cross-sectional analysis of the Japan Environment and Children’s Study
Authors: Yamada Keiko , Kimura Takashi , Cui Meishan , Tanaka Eizaburo , Kubota Yasuhiko , Ikehara Satoyo , Iso Hiroyasu 
Published: April 2023

AbstractThe aim of cross-sectional study was to investigate whether the presence of autistic traits in pregnant women was positively associated with the prevalence and severity of antenatal pain. We analyzed 89,068 pregnant women from a Japanese national birth cohort cross-sectionally. Autistic traits were assessed using the Japanese version of the Autism-Spectrum Quotient short form (AQ-10-J). Antenatal pain was measured using the SF-8 bodily pain item (SF-8-Pain). Antenatal pain in the second to third trimester during pregnancy was categorized into three groups: without pain, mild pain, and moderate-to-severe pain. Participants were divided into eight groups by AQ-10-J score: seven consecutive scoring groups (scores 0–6), and those above the cut-off (≥ 7) for probable autistic spectrum disorders. Odds ratios (OR) for the prevalence of mild and moderate-to-severe pain were calculated for each AQ-10-J scoring group (reference: without pain group) using multinominal logistic regression analysis. Autistic traits were positively associated with mild and moderate-to-severe pain in a dose–response manner, but the association with moderate-to-severe pain was strongest. Fully-adjusted ORs (95% confidence intervals) for moderate-to-severe pain were: 1.01 (0.91–1.13) for 1 point, 1.13 (1.02–1.25) for 2 points, 1.16 (1.04–1.29) for 3 points, 1.20 (1.07–1.34) for 4 points, 1.23 (1.09–1.40) for 5 points, 1.27 (1.10–1.47) for 6 points, and 1.24 (1.05–1.46) for ≥ 7 points (AQ-10-J cut-off). We identified an association between maternal autistic traits and antenatal pain. Maternal autistic traits may need to be considered when addressing antenatal pain during healthcare for expectant mothers.