bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACER2 forms a cold tumor microenvironment and predicts the molecular subtype in bladder cancer: Results from real-world cohorts
Authors: Liu Jinhui , Cheng Chunliang , Qi Tiezheng , Xiao Jiatong , Zhou Weimin , Deng Dingshan , Dai Yuanqing 
Published: March 2023

Background: ACER2 is a critical gene regulating cancer cell growth and migration, whereas the immunological role of ACER2 in the tumor microenvironment (TME) is scarcely reported. Thus, we lucubrate the potential performance of ACER2 in bladder cancer (BLCA).Methods: We initially compared ACER2 expressions in BLCA with normal urothelium tissues based on data gathered from the Cancer Genome Atlas (TCGA) and our Xiangya cohort. Subsequently, we systematically explored correlations between ACER2 with immunomodulators, anti-cancer immune cycles, tumor-infiltrating immune cells, immune checkpoints and the T-cell inflamed score (TIS) to further confirm its immunological role in BLCA TME. In addition, we performed ROC analysis to illustrate the accuracy of ACER2 in predicting BLCA molecular subtypes and explored the response to several cancer-related treatments. Finally, we validated results in an immunotherapy cohort and Xiangya cohort to ensure the stability of our study.Results: Compared with normal urinary epithelium, ACER2 was significantly overexpressed in several cell lines and the tumor tissue of BLCA. ACER2 can contribute to the formation of non-inflamed BLCA TME supported by its negative correlations with immunomodulators, anti-cancer immune cycles, tumor-infiltrating immune cells, immune checkpoints and the TIS. Moreover, BLCA patients with high ACER2 expression were inclined to the luminal subtype, which were characterized by insensitivity to neoadjuvant chemotherapy, chemotherapy and radiotherapy but not to immunotherapy. Results in the IMvigor210 and Xiangya cohort were consistent.Conclusion: ACER2 could accurately predict the TME and clinical outcomes for BLCA. It would be served as a promising target for precision treatment in the future.
Pengaruh Promsi dan Kualitas Produk Terhadap Keputusan Pembelian pada pelanggan PT. Biosafe Medan
Authors: Geofansa Irene Nur , Syahrial Hery , Isnaniah Isnaniah 
Published: March 2023

The study purposes to identify : 1) the effect of promotion has a positive and significant influence towards the customer’s Buying Decision at PT. Biosafe Medan. 2) the effect of product quality has a positive and significant influence towards the customer’s Buying Decision at PT. Biosafe Medan. 3) the effect of both promotion and product quality has a simultaneous influence towards the customer’s Buying Ddecision at PT. Biosafe Medan. An associative study was conducted using population size as much as 26,275 employees. A total 100 respondents of PT. Biosafe Medan were chosen as the sampel by using random samplig method. The study utilized the multiple linier regression analysis as the data analysing technique. The dta of this study were gathered through interview and distributing questionnaire. The study result obtained that promotion has a positif and significant influence towards the customer’s buying decision, where positive showed from the value 0,516 dan significant 0,000 0,05. Product quality has a positif dan significan influence towerds the customer’s buying decision, where positive showed prome the value 0,392 and significant 0,000 0,05. Both promotion and product quality has a positive and significant influence toweds the customer’s buying decision, where positif showed frome the value 2,711 and significant 0,000 0,05.
Síndrome de Laron: reporte de caso
Authors: Caraguay Sarahí Alejandra Vergara , Portilla Cristian Carlos Ramírez , Sánchez Julio César Ojeda , Di Rosa Rebeca Rodríguez , Ortiz Kevin Sebastian Criollo , Vivar María Angélica Córdova , Iñiguez Mateo Nicolás Andrade , Sanmartín Fausto Andrés Martínez 
Published: March 2023

Introducción e importancia: El síndrome de Laron es una condición genética rara, que se presenta con muy poca frecuencia. Esta enfermedad es tratada con un único medicamento denominado mecasermina para mejorar la calidad de vida del paciente, sin embargo, en ocasiones puede generar efectos adversos poco comunes. Caso clínico: Paciente femenina de 9 años de edad, con diagnóstico de Síndrome de Laron, confirmado mediante niveles bajos del factor de crecimiento similar a la insulina tipo 1 y niveles normales o elevados de la hormona del crecimiento, misma que recibió tratamiento temporal con mecasermina. Discusión clínica: Se inició el tratamiento con mecasermina con el peso de 9,8 kg y la talla de 89,2 cm. Siete meses después se manifestó hipertensión intracraneana, motivo por el cual, se suspendió el medicamento por tres meses, y posteriormente se lo retomó a dosis bajas. Un año diez meses después, en su último control se evidenció un peso de 15,1 kg y la talla de 97 cm. Conclusión: El síndrome de Laron es una condición rara que se caracteriza por una marcada talla baja, en la actualidad, el único tratamiento para mejorar el desarrollo de la estatura es la administración de mecasermina, la misma que tuvo resultados beneficiosos para la paciente investigada.
Perfil epidemiológico das uveítes infeciosas em hospital terciário em Belém, Pará
Authors: Da Trindade Junior Cantidio João Silva , Leão Roberto Freitas de Castro , Besteiro Alana Valéria Matos , Fernandes Ana Catarina Mattos , Xavier Tássio Cruz , De Sousa Daniele Salgado , Costa Dhiego Lima , Lima Vitor Hugo Auzier 
Published: March 2023

Objetivo: Descrever o perfil epidemiológico dos pacientes diagnosticados com uveítes infecciosas em hospital de referência em oftalmologia no estado do Pará. Métodos: É um estudo observacional, de corte transversal, analítico. A coleta de dados foi realizada a partir da análise dos prontuários dos pacientes por meio do Aplicativo de Gestão para Hospitais Universitários (AGHU). As variáveis estudadas no projeto são: sexo, faixa etária, classificação anatômica da uveíte e diagnóstico etiológico. Critérios de inclusão: pacientes com diagnóstico de uveíte infecciosa, maiores de 18 anos, de ambos os sexos e que foram atendidos no ambulatório de uveíte do HUBFS durante o período da coleta. Foram excluídos os pacientes que não apresentassem prontuários com todos os dados para preenchimento do protocolo de pesquisa. Resultados: A amostra foi composta por 69 pacientes, com maioria do sexo feminino, idade média de 43.3 anos, sendo as mais frequentes a faixa entre 50 a 59 anos (21.7%), seguida das faixas entre 20 a 29 anos e acima ou igual a 60 anos (20.3% ambas). Na avaliação do diagnóstico etiológico foi identificada maior proporção de Toxoplasmose (43.5%), seguida de Tuberculose e a iridociclite herpética. Em relação ao tipo de uveíte, a mais frequente foi a posterior (68.1%). A presença de HIV aconteceu em 09 pacientes e, entre eles o diagnóstico etiológico mais frequente foi a necrose aguda de retina, seguida da microangiopatia e da toxoplasmose. Conclusão: Os pacientes diagnosticados com uveítes infecciosas são predominantemente do sexo feminino, com faixa etária entre 50-59 anos e 20 a 29 anos. A etiologia mais frequente encontrada foi a Toxoplasmose, seguida de Tuberculose, e houve predominância da uveíte posterior.
Impacto do tratamento profilático no manejo da Asma
Authors: De Castro Ana Beatriz Sampaio Pinto , Lima Tatiana Montandon Lassi Lopes , Raposo Izabella Fonseca , De Oliveira Gleidston Teixeira , Correia Elisa de Castro , Silva Hellen Carolina Brandão , Da Silva Glicilla Paloma Dalfior 
Published: March 2023

Asma é uma doença prevalente e que, se não tratada, apresenta elevada morbidade. É comumente diagnosticada na infância e necessita de cuidados para manejo e controle. O presente trabalho avaliou o perfil dos pacientes asmáticos que necessitam de atendimento em serviço de urgência, o impacto da educação em asma quanto ao manejo da pré-crise e uso de profilaxia em relação à internação e busca de atendimento de urgência devido a essa doença. Trata-se de estudo descritivo, realizado a partir de uma amostra de conveniência, abrangendo crianças e adolescentes de 2 a 14 anos, com diagnóstico de asma, recrutados no pronto atendimento do Hospital Municipal Odilon Behrens no período de janeiro a agosto de 2022. Aplicou-se um questionário aos pais e responsáveis desses pacientes acerca do manejo da pré-crise, uso de medicação profilática, internações prévias e sinais de procura ao serviço de urgência. Quando não se utiliza medicação de profilaxia a necessidade de internação aumenta 69,6% e a necessidade de admissão em CTI aumenta 92,8%. Enquanto que com uso de profilaxia, a admissão em CTI cai para 42,8%. Concluiu-se que há um desfecho desfavorável nos que não utilizaram ou souberam manusear a medicação profilática.
Linfoma em aves
Authors: Quagliano Matheus Sedano 
Published: March 2023

Ao longo dos anos a medicina veterinária de animais silvestres e exóticos vem sendo estudada e aprimorada, levando um aumento na procura de pets não convencionais e profissionais desse ramo.
Baseado no parágrafo acima, é de grande importância que esses profissionais estejam sempre buscando conhecimento e se atualizando, principalmente quando se trata de uma doença oncológica.
Linfoma é uma neoplasia do sistema linfático que acomete órgãos linfo hematopoiéticos como fígado, baço, linfonodos e agregados linfoides adjacentes a mucosas, é considerado o tumor de origem hematopoiética mais importante em animais domésticos e uma das neoplasias que mais ocorre na medicina veterinária. Pode ser classificado de acordo com a origem anatômica nas formas: mediastinal, alimentar, extranodal, cutânea e multicêntrico. É caracterizado pela proliferação de linfócitos malignos, que podem ser classificados basicamente em T e B.
Os exames que podem ser utilizados para auxiliar no diagnóstico são citologia, hemograma, bioquímico, exames de imagens, histopatológico e imunohistoquímica. O protocolo de tratamento inclui a quimioterapia, radioterapia ou remoção cirúrgica, sendo a quimioterapia a mais utilizada.
A medicina de aves requer conhecimento biológico de cada espécie para diagnósticos mais precisos, pois é uma área muito ampla que envolve centenas de espécies de diversos tamanhos e características particulares. Existem poucos relatos de linfoma em aves comparado com pequenos animais, o que torna mais desafiador para o médico veterinário tanto no diagnóstico quanto no tratamento e prognóstico.
Community based Asian Agrifuture: how it can be achieved
Authors: Ito Nobutaka 
Published: March 2023

Asia is one of the most productive agricultural regions in the world, however the quality control of agricultural food products should be severely and strictly managed from the view point of food security and safety due to the increase of food feeding demand to cover the drastic and rapidly increase of world human population in recent years. We humans are facing two big global issues of energy and environment. Good solution finding is still under the efforts making on building a sustainable society, however no optimal solution has yet been found. Needless to say the special attention should be paid not to jeopardize the natural environment any more for stopping the global warming. Given the world's population, which is growing rapidly by 80 million people annually, it is easy to guess that food issues could become a major issue sooner or later. It is natural for us humans to be ready to prepare and address some message immediately if we know what is coming now around us. In this paper the current status of Asian agriculture in the world is overviewed first, then the Asian agrifuture is discussed and proposed from the community based viewpoint how it should / can be promoted and achieved.
Lesson Study Model Perception Scale: Validity and Reliability Study
Authors: Aykan Ahmet , Elkonca Fuat 
Published: March 2023

This study aimed to develop the “Lesson Study Model Perception Scale” (LSMPS) and to determine the psychometric properties of the scale. The study was designed as a survey model. A survey model is a research approach that aims to describe a situation as it is. When all the findings obtained to determine the psychometric properties of the scale developed within the scope of the research are evaluated together, it is investigated that the measurements obtained from the scale and the inferences to be made based on these findings are reliable and valid. Existing literature revealed that there are limited number of studies that determine how the LS model is perceived by teachers. It is seen that none of these studies attempted to develop a scale to measure teachers’ perceptions of the LS model. The lack of a study in this context in the literature shows the originality of the study.
Estágio supervisionado II e vivências do ensino remoto em instituição de ensino
Authors: Bonfim Cleide Teixeira , Almeida Cassiana Mendes dos Santos , Santos Maria Auxiliadora Freitas dos 
Published: March 2023

O presente trabalho tem como objetivo compreender os limites, as dificuldades e as possibilidades do ensino remoto em uma Escola Pública Municipal, tendo como metodologia a aplicação de sequências didáticas com uso de recursos tecnológicos investigativos no ensino de Ciências. Neste contexto, este estudo consiste em um relato da experiência de uma estudante do curso de Licenciatura em Ciências Biológicas do IF Baiano campus Serrinha, sobre o Estágio Curricular Supervisionado na perspectiva do ensino remoto. Visto que, para a docência na formação inicia, o Estágio é considerado elemento essencial no desenvolvimento ao estagiário de espaço/tempo, bem como de aproximação com a realidade da educação básica, assim como a dinâmica do fazer pedagógico em um contexto online, por meio da troca de experiências. Para elaboração deste trabalho foram descritas duas das dez sequências didáticas elaboradas, sendo elas: Órgãos das plantas: reprodução sexuada e reprodução assexuada; Pteridófitas e gimnospermas, ambas da área do reino vegetal. Sinalizando que apesar de desafiador o estágio remoto, a utilização das sequências didáticas facilitou o processo formativo de ensino aprendizagem e o desenvolvimento das metodologias com uma riqueza de experiência para a futura docente.
Abstract: This paper aims to understand the limits, difficulties and possibilities of remote teaching in a Municipal Public School, using as methodology the application of didactic sequences with the use of investigative technological resources in science teaching. In this context, this study is a report of the experience of a student of the Biological Sciences undergraduate course at the IF Baiano campus Serrinha, about the Supervised Curricular Internship in the perspective of remote teaching. Since, for teaching in the initial formation, the internship is considered an essential element in the development of space/time for the intern, as well as the approach to the reality of basic education, and the dynamics of pedagogical work in an online context, through the exchange of experiences. For the elaboration of this work, two of the ten didactic sequences elaborated were described, namely: Organs of plants: sexual and asexual reproduction; Pteridophytes and gymnosperms, both from the plant kingdom area. Signaling that despite the challenge of the remote internship, the use of the didactic sequences facilitated the formative process of teaching and learning and the development of methodologies with a wealth of experience for the future teacher.
Keywords: Teachers, Internship, Didactic sequences.
Monitoring the Stability of Oxygen Flow Analyzer on Oxygen Station in the Hospital
Authors: Rosida Nur Khabibatul , Rahmawati Triana , Nosike Maduka 
Published: March 2023

Oxygen therapy besides having benefits also has certain dangers and side effects. For this reason, oxygen therapy must be given at the proper dose by monitoring the patient regularly and adjusting the oxygen flowmeter. The accuracy of flowmeter under standard conditions is guaranteed by manufacturer. With time and use the precision may change and the flow accuracy given in a hospital setting may differ from the original value. Thepurpose of this research is to conduct further research on Oxygen flow analyzer which focuses on discussing the accuracy and stability of the oxygen flow sensor against the gold standard. Contribution of this study is to increase the range of oxygen flowrate measurement to 15 liters per minute (LPM). This research uses Arduino Mega while the gas flow sensor used is legris flow sensor. The measurement results are displayed on TFT LCD equipped with SD Card data storage. The gas flowrate is regulated using a flowmeter (GEA). Meanwhile the comparison tools using Oxygen Analyzer and 1 m3 oxygen gas cylinder. At the testing stage, the sensor reading value on the module that appears on the TFT LCD is compared with the resultsf a comparison tool with a measurement range of 1 LPM to 15 LPM 6 times at each point. The conclusion from these results is that the calibrator module has a relative error is still within the allowable tolerance limit of ±10%.
INDEX TERMS Calibration, Oxygen Flow Analyzer, Flowmeter, TFT Display
Characterizing Phase Noise in Radar
Authors: Steyn Werner , Van Der Walt PW 
Published: March 2023

<p>There is some confusion in the radar community on the handling of phase noise in radar because current definitions give rise to divergent integrals. </p>
<p>It is shown that the spectrum of a phase noise modulated signal rather than the spectrum of the phase noise modulating function is the applicable function for coherent radar system design. </p>
<p>A heuristic model is proposed to derive the finite power signal spectrum from the infinite power phase spectrum.</p>
<p>The well-known phase delay differencing function that is used to weigh the base-band phase noise before integration is also discussed and applied to typical spectra to obtain well behaved analytical descriptions of phase noise that lead to convergent integrals for the autocorrelation and noise power.</p>
موارد ومنهج أبي عبيدة معمر بن المثنى في رواية وكتابة السيرة النبوية
Authors: الابراهيمي حسن 
Published: March 2023

قدم أبوعبيدة نتاجا ملحوظا في أخبار السيرة النبوية فقد وظف أخباره في التصنيف فيها فضلا عن اسهامه في رواية اخبارها ، ولما كانت مادته في السيرة النبوية غزيرة ينبغي الاعتماد عليها لذا عدت احدى الدعامات المهمة التي استندت إليها المصنفات لاحقا عند عرضها السيرة وبذلك مهد لظهور المؤرخين الكبار وقد عُد من الذين أسسوا لبناء المنهج التأريخي والذين ألموا مرحليا بالقواعد الاساسية لما احتواه تراثهم من دلالات منهجية يمكن عدها أولى محاولات فصل التأريخ عن الادب .
موقف سوريا من مشاريع الاحلاف الغربية في الشرق الاوسط 1950 - 1955
Authors: عباس علي 
Published: March 2023

تعد نهاية الحرب العالمية الثانية ( 1939 ــــ 1945 ) نقطة تحول بارزة في العلاقات الدولية , فقد ظهرت قوى جديدة اصبح لها دوراً كبيراً في مجال السياسة الدولية , هما الولايات المتحدة الامريكية زعيمة الدول الغربية , والاتحاد السوفيتي زعيم الدول الشرقية , اذ شهدت الخمسينيات سلسلة من محاولات الدول الغربية عن فرض المشاريع والاحلاف الغربية المشتركة لتطويق الاتحاد السوفيتي للحد من نشاطه ومنع توسيع نفوذه في منطقة الشرق الاوسط ولاسيما المنطقة العربية , وذلك للحفاظ على مصالحها الاقتصادية بالمنطقة , وحماية اسرائيل من الاعتداءات العربية ومن هذه المشاريع والاحلاف , التصريح الثلاثي ايار 1950 , ومشروع قيادة الشرق الاوسط 1951 , وحلف بغداد 1955 اذ رفضت سوريا هذه المشاريع واعتبرتها تدخلا في الشؤون الداخلية لدول المنطقة العربية ولاسيما سوريا .
الاجتهاد التخصصي بين المنع والجواز
Authors: كاظم احمد , المنصوري صلاح 
Published: March 2023

تناول هذا البحث عنوان (الاجتهاد التخصصي بين المنع والجواز) من خلال مقدمة وثلاثة مطالب. وتناول في المقدمة مدى الحاجة إلى الاجتهاد في الشريعة الإسلامية مع ذكر أهم موضوعات البحث. أما المطلب الأول فكان حول صور وأنواع الاجتهاد المتخصص عند المذاهب الإسلامية. وفي المطلب الثاني اقوال العلماء بالجواز الاجتهاد المتخصص ، وفي الفصل الثالث ذكر البحث أقوال العلماء في منع هذا النوع من الاجتهاد ، وفيه تفصيل أقوال كل مذهب من المذاهب الإسلامية ، وانهيت هذا البحث بخاتمة اشتملت على عدة نقاط في محتوياتها لاهم ما انتهى اليه البحث.
اثر الغزو السوفيتي لأفغانستان على العلاقات السوفيتية-الباكستانية 1980
Authors: الموسوي ربيع , مهدي سحر 
Published: March 2023

يتحدث البحث عن العلاقات السوفيتية – الباكستانية خلال عام 1980 الذي شهد تطورات مهمة على المستوى الإقليمي والدولي لاسيما بعد الاحتلال السوفيتي لأفغانستان في 27 كانون الاول 1979، الامر الذي زاد من توتر العلاقات السوفيتية – الباكستانية ابان ذلك العام وخلق ازمة سياسية في علاقات البلدين ظلت اثارها مستمرة لعدة سنوات ، وقد سلط البحث على طبيعة علاقات البلدين وما صاحبها من مفاوضات جرت بينهما بشأن حل الازمة الأفغانية .
قسم البحث الى محورين تضمن المحور الاول: ردود الفعل الباكستانية عقب الغزو السوفيتي لأفغانستان خلال عام 1980، اما المحور الثاني فقد تحدث عن طبيعة العلاقات بين البلدين خلال عام 1980
A Sociopragmatic Study of Feminism: A theoretical Perspective of Feminist Discourse
Authors: Hadi Shahad , Mahdi Hasan 
Published: March 2023

The current paper is an attempt to approach feminism in Sociopragmatic structures. It pragmatically tackles feminism in this feminist work. Consequently, it aims to: explain the socio-pragmatic structure of feminist discourse that is the socio-pragmatic elements of which the feminist discourse of the theortical wor under study is composed; identify the most frequently socio-pragmatic straetgies that are made use of feminism depicted in the work under study;To fulfil the aims of this study in which it is hypothesized that Speech acts, deixis, presupposition, conversational implicatures and politeness are the major pragmatic strategies of the feminist discourse of the novel under investigation. Moreover ,Sexism, power, domiance, gender elements are the crucial sociolinguistic elements that construct the sociolinguistic construct of the feminist discourse . Finally , there are some interrelationship between pragmatics and sociolinguistics to find the overall feminist veiw .
التعليم الثانوي والمهني في مدينة كربلاء المقدسة 1968 ــ 1979
Authors: الحلو نبيل , الجزائري محمد 
Published: March 2023

تناول الباحث دراسة التعليم في مدينة كربلاء المقدسة ، كونها من المدن التاريخية الاسلامية المهمة ، التي كانت مدارسها الدينية مزدهرة في الدراسة لاسيما الحوزوية منها ، فقد ضمت حلقات الدرس فيها كثير من العلماء والفقهاء ، فساهم التعليم في تنمية قدرات الطلبة بالعلوم والمعارف والقيم النبيلة والمهارات والتوجهات التي تمكنهم من مواجهة متطلبات الحياة اليومية ، فضلاً عن مستواهم الخدمي والصحي، مما تزاد من فرص مشاركتهم في الحياة السياسية ، ومكنهم من المساهمة بشكل أفضل في التنمية الاقتصادية لبلادهم ، وتقليص حالة الفقر والجهل لديهم ، وقد اختار الباحث المدة الزمنية 1968- 1979 لدراسته كونها مرحلة زمنية اختلفت في سماتها وخصائصها عما قبلها في كافة المجالات ومنها مجال التعليم وتطوره.
Phonosemantic Study of Some Selected Hollywood Action Movies’ Titles
Authors: Alsalihy Hamza , Rashid Balqis 
Published: March 2023

The present study tries to check the phonosemantic meaning that sounds have in some selected Hollywood action movies’ titles. The study adopts the Universal Theory that Agrawal suggested (2010) as a model for the analysis. The chosen movies are those movies which won or were nominated for the Oscar award and other awards, such as BAFTA. The study can reveal the association between the selected movies’ titles and their events. The present study is intended to accomplish the following objectives: First shedding light on the phonological features and patterns that are found in the titles of the selected movies. Second, finding out the association between the sounds and the meanings of the titles and their reflection on the events of the related movies, and third, checking phonologically the stylistic features of the sound patterns in titles of the chosen movies. Among the most important conclusions of the study are : Sounds are meaning-bearing elements and titles reflect the events of their movies.