bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcranial Direct Current Stimulation in Nicotine Use
Authors: Gwon Seok Hyun , Lee Han-Joo , Brian Ahn Hyochol 
Published: September 2023

Abstract
Tobacco use is a leading cause of cancer, cardiovascular and respiratory disease, and preventable death in the United States. The brains of individuals with nicotine dependence are characterized by damaged mesolimbic pathways in the medial portion of the limbic and frontal lobes, creating positive reinforcing mechanisms. Transcranial direct current stimulation (tDCS) targets this neuroadaptation to improve smokers' nicotine-related outcomes, such as craving and smoking behavior, by depolarizing or hyperpolarizing the neurons of the brain. Recent literature reported promising outcomes in smokers after tDCS treatment interventions. tDCS has great potential for clinical nursing research for tobacco control given its multiple methodological advantages and few disadvantages. Nurse researchers can consider individualized and home-based tDCS interventions for community-based tobacco control research and may need to consider objective outcome measures (e.g., cotinine in urine) and addiction-related cognitive variables (e.g., self-regulation). Users of electronic nicotine delivery systems also need to be considered as participants in tDCS interventions. Additional considerations for nursing research are discussed.
The Intersection of Nurses With Substance Use Disorder and Peer Support
Authors: Scholler Brooke , Waite-Labott Kristin , DeMark Misty 
Published: September 2023

Abstract
Support within the nursing community for those coping with substance misuse has been lacking for over a hundred years. A review of the history of substance use disorders in nursing reveals that nurses still encounter similar risks, stigma, and punishments today. Kristin, a nurse for over 30 years, tells her story of trials, tribulations, and triumphs with substance use. She shares how having to face early recovery on her own sparked the development of the Wisconsin Peer Alliance for Nurses (WisPAN). WisPAN offers a community for nurses in recovery to provide peer support to those taking their first steps on the journey toward recovery.
Multilineage differentiation potential in the infant adipose- and umbilical cord-derived mesenchymal stem cells
Authors: Huang Hui-Kuang , Hsueh Kuang-Kai , Liao Yu-Ting , Wu Szu-Hsien , Chou Po-Hsin , Yeh Shih-Han , Wang Jung-Pan 
Published: September 2023

Background:
This study aims to compare the biological properties of infant adipose-derived mesenchymal stem cells (infant ADSCs) from excised polydactyly fat tissue and umbilical cord-derived mesenchymal stem cells (UCSCs) in terms of proliferation and differentiation capabilities. The proliferation of infant ADSCs and UCSCs was analyzed by determining the fold changes of cell numbers and doubling time periods.

Methods:
The state of senescence and replicative stress was compared by analyzing the expression of age-related genes, senescence-associated β-galactosidase (SA-β-gal) staining, and phosphorylated histone variant H2AX (γH2AX) immunofluorescence staining. The expression levels of superoxide dismutase (SODs) and genes related to multilineage differentiation were analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Differentiation levels were determined using histochemical staining, immunohistochemical staining, and immunofluorescence staining.

Results:
Infant ADSCs exhibited higher proliferation rates and expression levels of SOD1, SOD2, and SOD3 at passages 3–5 compared with UCSCs. Senescence related genes (p16, p21, and p53), SA-β-gal staining, and replicative stress analysis were reduced in infant ADSCs. The expression levels of chondrogenic genes (COL2 and COL10), osteogenic genes (RUNX2 and ALP), adipogenic genes (LPL), and hepatogenic genes (ALB and TAT) in infant ADSC-differentiated cells were significantly higher than those in UCSCs. Histochemical and immunofluorescence staining confirmed these results. Only the expression levels of tenogenic genes (MMP3, DCN, and COL3) in infant ADSC-differentiated cells were lower than those in UCSCs.

Conclusion:
Infant ADSCs exhibit higher proliferation rates, reduced cellular senescence and replicative stress, better antioxidative activity, and higher differentiation potential toward chondrogenic, osteogenic, adipogenic and hepatogenic lineages than UCSCs.
Approaches of laparoscopic anatomical liver resection of segment 8 for hepatocellular carcinoma: A retrospective cohort study of short-term results at multiple centers in China
Authors: Wang Xingru , Li Jianwei , Cao Jun , Zhang Qifan , Wei Yonggang , Cheng Wei , Liang Xiao , Tian Feng , Wang Xin , Xu Hongwei , Chen Jie , Zhou Ning , Yang Zaibo , Tao Changcheng , Wang Hongguang 
Published: September 2023

Background:
Laparoscopic anatomical liver resection of segment 8 (LALR-S8) remains a challenge for anatomical laparoscopic segmentectomy. Most current reports on LALR-S8 are case series using one surgical approach, and there is a lack of multicenter data on identifying intersegmental planes using different approaches. In this study, we aimed to elucidate the short-term results of three different approaches for LALR-S8 for hepatocellular carcinoma (HCC), focusing on intersegmental plane determination, and to reflect on current practice regarding different approaches at multiple centers in China.

Materials and methods:
The clinical cohort data of 122 patients who underwent LALR-S8 for HCC at seven leading centers in China were retrospectively analyzed. The surgical procedures of all approaches were summarized and standardized according to the method of the Glissonean pedicle of segment 8 identification. The postoperative short-term outcomes and oncological results of the three approaches were evaluated and compared.

Results:
Three approaches were used: laparoscopic ultrasonography-guided indocyanine green (ICG) fluorescent positive staining approach (11/122, 9.02%), hepatic vein-guided approach (99/122, 81.15%), and Glissonean ICG fluorescent negative staining approach (12/122, 9.83%). Seven (5.73%) patients experienced complications according to the Clavien–Dindo (CD) classification, and the rate of grade ≥IIIa complications was 2.46%. The R0 resection rates among the groups (margin >1 mm) and the margin width showed no statistical difference.

Conclusion:
LALR-S8 is safe and feasible for treating HCC under standardized surgical techniques and appropriate surgical approaches. The three reported approaches had comparable short-term oncological outcomes, while the hepatic vein-guided approach was most commonly used.
Evolving nutritional needs, obesity, and overweight status in cystic fibrosis
Authors: Szentpetery Sylvia E. 
Published: September 2023

Purpose of reviewThe nutritional landscape in cystic fibrosis has shifted dramatically in the era of CFTR modulator therapy. In this review, we will critically examine the literature on overweight and obesity in CF, current nutritional care unknowns and opportunities for further investigation or adaptation in clinical care.Recent findingsResults of clinical trial and real-world data reflect marked improvement in nutritional status and quality of life. Clinical outcomes including CF related diabetes and CF related liver disease appear positively impacted. Secondary impacts on cardiometabolic disease have been noted, especially in association with excessive weight gain.SummaryThe prior approaches to optimizing nutrition in cystic fibrosis with caloric excess can likely be safely retired for many. As modulator access expands across the lifespan, a longitudinal focus on health maintenance should be considered.
Factor XI as a therapeutic target in neuroinflammatory disease
Authors: Taskin Berk , Kohs Tia C.L. , Shatzel Joseph J. , Puy Cristina , McCarty Owen J.T. 
Published: September 2023

Purpose of review
This review summarizes the pathophysiology and potential therapeutic options for treatment of multiple sclerosis, a common neuronal demyelinating disorder affecting 2.2 million people worldwide. As an autoimmune disorder, multiple sclerosis is associated with neuroinflammation and increased permeability of the blood–brain barrier (BBB), although the cause linking multiple sclerosis with compromised barrier function remains ill-defined. It has been previously shown that coagulation factors, including thrombin and fibrin, exacerbate the inflammatory processes and permeability of the BBB.

Recent findings
Increased levels of the coagulation factor (F) XII have been found in patients presenting with relapsing–remitting multiple sclerosis, with a deleterious role for FXII being validated in murine model of multiple sclerosis, experimental autoimmune encephalitis (EAE). Recent work has uncovered a role for the major substrate activated by FXII and thrombin, FXI, in the disorder of EAE. The study found that pharmacological targeting of FXI decreased clinical symptoms, lymphocyte invasion, and white matter destruction in a multiple sclerosis model.

Summary
This review emphasizes the role of FXII and FXI in regulating barrier function and the immune response in neuroinflammation. These new findings broaden the potential for therapeutic utility of FXI inhibitors beyond thrombosis to include neuroinflammatory diseases associated with compromised BBB function, including multiple sclerosis.
The Association Between Magnet® Recognition and Patient Outcomes
Authors: Connor Linda , Beckett Cindy , Zadvinskis Inga , Melnyk Bernadette Mazurek , Brown Roy , Messinger Jeffery , Gallagher-Ford Lynn 
Published: September 2023

BACKGROUND
Previous systematic reviews have explored nurse, patient, and organizational outcomes in Magnet®-recognized hospitals compared with non-Magnet hospitals, yet these did not comprehensively review a wide variety of patient outcomes.

AIM
The purpose of this scoping review was to describe the findings from published research evaluating patient outcomes in Magnet-recognized hospitals compared with non-Magnet hospitals.

METHODS
A medical librarian conducted a systematic search for published peer-reviewed, English-language literature and a search of the reference lists for retrieved publications to identify articles addressing Magnet compared with non-Magnet hospitals related to patient outcomes.

RESULTS
Four patient outcomes improved in Magnet-designated hospitals: mortality, patient satisfaction, failure to rescue, and falls. Four patient outcomes showed undesirable or mixed outcomes. Five patient outcomes had insufficient evidence regarding patient outcomes when treated at Magnet-recognized hospitals.

CONCLUSION
Magnet Recognition® is associated with improvement in a distinct set of patient outcomes, but not all key outcome measures. Standardized outcomes and rigorous study designs are needed to further explore the impact of Magnet Recognition on a wide variety of patient outcomes.
Utility of Hospital Failure to Rescue for Analyzing Variation in Pediatric Postoperative Mortality
Authors: Mehl Steven C. , Portuondo Jorge I. , Tian Yao , Raval Mehul V. , Shah Sohail R. , Vogel Adam M. , Wesson David , Massarweh Nader N. 
Published: September 2023

OBJECTIVES:
To evaluate the association between pediatric hospital performances in terms of failure to rescue (FTR), defined as postoperative mortality after a surgical complication, and mortality among patients without a surgical complication.

DESIGN:
Retrospective cohort study.

SETTING:
Forty-eight academic, pediatric hospitals; data obtained from Pediatric Health Information System database (Child Health Corporation of America, Shawnee Mission, KS) (2012–2020).

PATIENTS:
Children who underwent at least one of 57 high-risk operations associated with significant postoperative mortality.

EXPOSURES:
Hospitals were stratified into quintiles of reliability adjusted FTR (lower than average FTR in quintile 1 [Q1], higher than average FTR in quintile 5 [Q5]). Multivariable hierarchical regression was used to evaluate the association between hospital FTR performance and mortality among patients who did not have a surgical complication.

MEASUREMENTS AND MAIN RESULTS:
Among 203,242 children treated across 48 academic hospitals, the complication and overall postoperative mortality rates were 8.8% and 2.3%, respectively. Among patients who had a complication, the FTR rate was 8.8%. Among patients who did not have a complication, the mortality rate was 1.7%. There was a 6.5-fold increase in reliability adjusted FTR between the lowest and highest performing hospitals (lowest FTR hospital—2.7%; 95% CI [1.6–3.9]; highest FTR hospital—17.8% [16.8–18.8]). Complex chronic conditions were highly prevalent across hospitals (Q1, 72.7%; Q2, 73.8%; Q3, 72.2%; Q4, 74.0%; Q5, 74.8%; trend test p < 0.01). Relative to Q1 hospitals, the odds of mortality in the absence of a postoperative complication significantly increased by 33% at Q5 hospitals (odds ratio 1.33; 95% CI [1.07–1.66]). This association was consistent when limited to patients with a complex chronic condition and neonates.

CONCLUSION:
FTR may be a useful and valid surgical quality measure for pediatric surgery, even when considering patients without a postoperative complication. These findings suggest practices and processes for preventing FTR at high performing pediatric hospitals might help mitigate the risk of postoperative mortality even in the absence of a postoperative complication.
Review of Traditional First Aid for Burn Injuries in the 21st Century
Authors: Hafizurrachman Muhammad , Menna Clara , Lesmana Elvira 
Published: September 2023

IntroductionThis review aims to investigate data on traditional burn first aid materials used in different countries.MethodsA systematic search was performed through 8 databases for studies on traditional burn first aid published in the 21st century. Data regarding study demographics, burn first aid, first aid materials, water irrigation, and source of knowledge were summarized, and the use of each material was discussed.ResultsA total of 28 studies including 20,150 subjects were identified. An average of 29% of the study population applied water irrigation, whereas 46% used various traditional materials, and 30% did not administer first aid. People with higher education and socioeconomy class tend to choose correct first aid actions.DiscussionThe single best treatment as burn first aid is cool-water irrigation. Despite that, various other materials have been used, most of which are not suitable for first aid. Some materials possess healing abilities and can be used as wound dressing, whereas others are harmful. Inappropriate materials are mostly used in underdeveloped regions lacking water access and hygiene. Mass media and community knowledge have a large influence in burn first aid practices.ConclusionRaising public health awareness on burn first aid is crucial along with providing the people access to water, basic hygiene, and health care.
Undiagnosed Lambert-Eaton Myasthenic Syndrome in the Era of Sugammadex: A Case Report
Authors: Yoon Jenny J. , Anderson Alexandra L. , Niesen Adam D. 
Published: September 2023

Objective
In this case report, we discuss the rare manifestation of prolonged neuromuscular blockade in a patient with history of small cell lung cancer and undiagnosed Lambert-Eaton myasthenic syndrome (LEMS) who had previously received succinylcholine for general anesthesia without incident but subsequently exhibited prolonged neuromuscular blockade during a laparoscopic procedure. We aimed to emphasize the importance of reversal agent safety and precision as well as vigilant perioperative and postoperative care.

Methods
We used the patient's electronic medical record, direct patient care experiences, and comprehensive literature review for this case report.

Results
Sugammadex was administered with mild improvement. Suspecting undiagnosed LEMS, neostigmine was administered, yielding satisfactory muscle strength and successful extubation. In retrospect, the patient reported history of weakness when lifting weights that improved upon exertion.

Conclusions
Sugammadex is an efficient and effective agent for reversal of neuromuscular blockade. However, proper monitoring of the depth and recovery of blockade is imperative to when using sugammadex with optimal safety and precision in all patients. Perioperative care teams must remain vigilant with a high index of suspicion for neuromuscular junction pathology to properly plan perioperative care for patients at risk, especially those with small cell lung cancer who may have undiagnosed LEMS.
WITHDRAWN: Mechanism of the microRNA-4677-3p/LDHB axis in the regulation of paclitaxel resistance of breast cancer cells
Authors: Chen Ying , Dong Qinzuo , Xing Liwei , Yang Jun , Sun Yuhuan , Zhang Junbao , Zhao Rong 
Published: September 2023

Withdrawal StatementThe authors have withdrawn their manuscript owing to the statistical analysis using the original database was found to have some problems. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
Adeno-to-squamous transition drives resistance to KRAS inhibition inLKB1mutant lung cancer
Authors: Tong Xinyuan , Patel Ayushi S. , Kim Eejung , Li Hongjun , Chen Yueqing , Li Shuai , Liu Shengwu , Dilly Julien , Kapner Kevin S. , Xue Yun , Hover Laura , Mukhopadhyay Suman , Sherman Fiona , Mynzdar Khrystyna , Gao Yijun , Li Fei , Li Fuming , Fang Zhaoyuan , Jin Yujuan , Gao Juntao , Shi Minglei , Chen Luonan , Chen Yang , Kheoh Thian , Yang Wenjing , Yanai Itai , Moriera Andre L. , Velcheti Vamsidhar , Neel Benjamin G. , Hu Liang , Christensen James G. , Olson Peter , Gao Dong , Zhang Michael Q. , Aguirre Andrew J. , Wong Kwok-Kin , Ji Hongbin 
Published: September 2023

SummaryKRASG12Cinhibitors including adagrasib and sortorasib have shown clinical promise in targetingKRASG12C-mutated lung cancers, however, most patients eventually develop drug resistance. In lung adenocarcinoma patients with co-occurringKRASG12CandSTK11/LKB1mutations, we found a high squamous gene signature at baseline significantly correlated with poor adagrasib response. Through integrative studies ofLkb1-deficientKRASG12CandKrasG12Dlung cancer mouse models and/or organoids treated with KRAS inhibitors, we found tumor cells invoked a lineage plasticity program: adeno-to-squamous transition (AST) that mediated resistance to KRAS inhibition. Transcriptomic and epigenomic analyses revealed ΔNp63 drives AST and modulates response to KRAS inhibition. We identified an intermediate high-plasticity cell state with distinct gene expression program marked byKrt6aupregulation. Notably, higherKRT6Aexpression at baseline correlated with shorter overall survival inKRAS-mutant patients receiving adagrasib. These data support the role of AST in KRAS inhibitor resistance and provide predictive biomarker for KRAS-targeted therapies in lung cancer.
Key Proteins for Regeneration inA. mexicanum: Transcriptomic Insights from Aged and Juvenile Limbs
Authors: del Moral-Morales Aylin , Sámano Cynthia , Ocampo-Cervantes José Antonio , Topf Maya , Baumbach Jan , González-Barrios Rodrigo , Soto-Reyes Ernesto 
Published: September 2023

AbstractThe axolotl is an animal with remarkable regenerative abilities, making it an ideal model for studying potential regenerative therapies in mammals, including humans. However, the molecular mechanisms involved in regeneration remain unclear. We conducted a transcriptomic analysis of juvenile axolotls’ limbs and their blastema and compared the results with aged axolotls that failed to regenerate after amputation. We identified a set of genes involved in cell differentiation, transcriptional regulation, cartilage development, bone morphogenesis, and extracellular matrix remodeling. Four highly expressed genes (FSTL1, ADAMTS17, GPX7, andCTHRC1) were identified in regenerating tissue, but underexpressed in aged axolotls. Structural and homology analysis showed that these genes are conserved and have important roles in development, bone morphogenesis, and cartilage formation. Our findings propose a novel set of axolotl genes involved in tissue regeneration that could be a starting point for further studies in other vertebrates.Graphical abstract
Reduced S-nitrosylation of TGFβ1 elevates its binding affinity towards the receptor and promotes fibrogenic signaling in the breast
Authors: Letson Joshua , Furuta Saori 
Published: September 2023

AbstractTransforming Growth Factor β (TGFβ) is a pleiotropic cytokine closely linked to tumors. TGFβ is often elevated in precancerous breast lesions in association with epithelial-to-mesenchymal transition (EMT), indicating its contribution to precancerous progression. We previously reported that basal nitric oxide (NO) levels declined along with breast cancer progression. We then pharmacologically inhibited NO production in healthy mammary glands of wild-type mice and found that this induced precancerous progression accompanied by desmoplasia and upregulation of TGFβ activity. In the present study, we tested our hypothesis that NO directly S-nitrosylates (forms an NO-adduct at a cysteine residue) TGFβ to inhibit the activity, whereas the reduction of NO denitrosylates TGFβ and de-represses the activity. We introduced mutations to three C-terminal cysteines of TGFβ1 which were predicted to be S-nitrosylated. We found that these mutations indeed impaired S-nitrosylation of TGFβ1 and shifted the binding affinity towards the receptor from the latent complex. Furthermore,in silicostructural analyses predicted that these S-nitrosylation-defective mutations strengthen the dimerization of mature protein, whereas S-nitrosylation-mimetic mutations weaken the dimerization. Such differences in dimerization dynamics of TGFβ1 by denitrosylation/S-nitrosylation likely account for the shift of the binding affinities towards the receptor vs. latent complex. Our findings, for the first time, unravel a novel mode of TGFβ regulation based on S-nitrosylation or denitrosylation of the protein.Significance statementTransforming Growth Factor β (TGFβ) is a widely studied cytokine associated with tumors. Because of its pleiotropic functions and dichotomous roles in tumorigenesis, the development of therapeutics targeted to TGFβ for cancer treatment has been challenging. In the present study, we report that TGFβ is indeed S-nitrosylated at specific sites for repressing its functions, whereas it is denitrosylated to derepress its activity. Such covalent modification-based regulation of TGFβ activity could potentially be utilized to design a new type of inhibitor or activator of the protein.