bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative vascular assessment of patients with a supracondylar humeral fracture and a perfused, pulseless limb
Authors: Holme Thomas J. , Crate Georgina , Trompeter Alex J. , Monsell Fergal P. , Bridgens Anna , Gelfer Yael 
Published: March 2023

AimsThe ‘pink, pulseless hand’ is often used to describe the clinical situation in which a child with a supracondylar fracture of the humerus has normal distal perfusion in the absence of a palpable peripheral pulse. The management guidelines are based on the assessment of perfusion, which is difficult to undertake and poorly evaluated objectively. The aim of this study was to review the available literature in order to explore the techniques available for the preoperative clinical assessment of perfusion in these patients and to evaluate the clinical implications.MethodsA systematic literature review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and registered prospectively with the International Prospective Register of Systematic Reviews. Databases were explored in June 2022 with the search terms (pulseless OR dysvascular OR ischaemic OR perfused OR vascular injury) AND supracondylar AND (fracture OR fractures).ResultsA total of 573 papers were identified as being suitable for further study, and 25 met the inclusion criteria for detailed analysis. These studies included a total of 504 patients with a perfused, pulseless limb associated with a supracondylar humeral fracture. Clinical examination included skin colour (23 studies (92%)), temperature (16 studies (64%)), and capillary refill time (13 studies (52%)). Other investigations included peripheral oxygen saturation (SaO2) (six studies (24%)), ultrasound (US) (14 (56%)), and CT angiogram (two studies (8.0%)). The parameters of ‘normal perfusion’ were often not objectively defined. The time to surgery ranged from 1.5 to 12 hours. A total of 412 patients (82%) were definitively treated with closed or open reduction and fixation, and 92 (18%) required vascular intervention, ranging from simple release of entrapped vessels to vascular grafts.ConclusionThe description of the vascular assessment of the patient with a supracondylar humeral fracture and a pulseless limb in the literature is variable, with few objective criteria being used to define perfusion. The evidence base for decision-making is limited, and further research is required. We were able, however, to make some recommendations about objective criteria for the assessment of these patients, and we suggest that these are performed frequently to allow the detection of any deterioration of perfusion.Cite this article: Bone Joint J 2023;105-B(3):231–238.
A comparison of clinical thresholds for revision following total and unicompartmental knee arthroplasty
Authors: Tay Mei L. , Monk A. P. , Frampton Christopher M. , Hooper Gary J. , Young Simon W. 
Published: March 2023

AimsUnicompartmental knee arthroplasty (UKA) has higher revision rates than total knee arthroplasty (TKA). As revision of UKA may be less technically demanding than revision TKA, UKA patients with poor functional outcomes may be more likely to be offered revision than TKA patients with similar outcomes. The aim of this study was to compare clinical thresholds for revisions between TKA and UKA using revision incidence and patient-reported outcomes, in a large, matched cohort at early, mid-, and late-term follow-up.MethodsAnalyses were performed on propensity score-matched patient cohorts of TKAs and UKAs (2:1) registered in the New Zealand Joint Registry between 1 January 1999 and 31 December 2019 with an Oxford Knee Score (OKS) response at six months (n, TKA: 16,774; UKA: 8,387), five years (TKA: 6,718; UKA: 3,359), or ten years (TKA: 3,486; UKA: 1,743). Associations between OKS and revision within two years following the score were examined. Thresholds were compared using receiver operating characteristic analysis. Reasons for aseptic revision were compared using cumulative incidence with competing risk.ResultsFewer TKA patients with ‘poor’ outcomes (≤ 25) subsequently underwent revision compared with UKA at six months (5.1% vs 19.6%; p < 0.001), five years (4.3% vs 12.5%; p < 0.001), and ten years (6.4% vs 15.0%; p = 0.024). Compared with TKA, the relative risk for UKA was 2.5-times higher for ‘unknown’ reasons, bearing dislocations, and disease progression.ConclusionCompared with TKA, more UKA patients with poor outcomes underwent revision from early to long-term follow-up, and were more likely to undergo revision for ‘unknown’ reasons, which suggest a lower clinical threshold for UKA. For UKA, revision risk was higher for bearing dislocations and disease progression. There is supporting evidence that the higher revision UKA rates are associated with lower clinical thresholds for revision and additional modes of failure.Cite this article: Bone Joint J 2023;105-B(3):269–276.
Impaction procedure influences primary stability of acetabular press-fit components
Authors: Ruhr Miriam , Huber Gerd , Niki Yasaman , Lohner Larissa , Ondruschka Benjamin , Morlock Michael M. 
Published: March 2023

AimsThe aim of the study was to investigate whether the primary stability of press-fit acetabular components can be improved by altering the impaction procedure.MethodsThree impaction procedures were used to implant acetabular components into human cadaveric acetabula using a powered impaction device. An impaction frequency of 1 Hz until complete component seating served as reference. Overimpaction was simulated by adding ten strokes after complete component seating. High-frequency implantation was performed at 6 Hz. The lever-out moment of the acetabular components was used as measure for primary stability. Permanent bone deformation was assessed by comparison of double micro-CT (µCT) measurements before and after impaction. Acetabular component deformation and impaction forces were recorded, and the extent of bone-implant contact was determined from 3D laser scans.ResultsOverimpaction reduced primary acetabular component stability (p = 0.038) but did not significantly increase strain release after implantation (p = 0.117) or plastic deformations (p = 0.193). Higher press-fits were associated with larger polar gaps for the 1 Hz reference impaction (p = 0.002, R2 = 0.77), with a similar trend for overimpaction (p = 0.082, R2 = 0.31). High-frequency impaction did not significantly increase primary stability (p = 0.170) at lower impaction forces (p = 0.001); it was associated with smaller plastic deformations (p = 0.035, R2 = 0.34) and a trend for increased acetabular component relaxation between strokes (p = 0.112). Higher press-fit was not related to larger polar gaps for the 6 Hz impaction (p = 0.346).ConclusionOverimpaction of press-fit acetabular components should be prevented since additional strokes can be associated with increased bone damage and reduced primary stability as shown in this study. High-frequency impaction at 6 Hz was shown to be beneficial compared with 1 Hz impaction. This benefit has to be confirmed in clinical studies.Cite this article: Bone Joint J 2023;105-B(3):261–268.
High-Q chalcogenide racetrack resonators based on the multimode waveguide
Authors: Wang Zhiyuan , Yang Zhen , Wang Haoxian , Zhang Wei , Wang Rongping , Xu Peipeng 
Published: March 2023

We propose and demonstrate a high quality (Q) factor racetrack resonator based on uniform multimode waveguides in high-index contrast chalcogenide glass film. Our design features two carefully designed multimode waveguide bends based on modified Euler curves, which enable a compact 180° bend and reduce the chip footprint. A multimode straight waveguide directional coupler is utilized to couple the fundamental mode without exciting higher-order modes in the racetrack. The fabricated micro-racetrack resonator shows a record-high intrinsic Q of 1.31×106 for selenide-based devices, with a relatively low waveguide propagation loss of only 0.38 dB/cm. Our proposed design has potential applications in power-efficient nonlinear photonics.
The changing epidemiology of shigellosis in Australia, 2001–2019
Authors: Ibrahim Aaliya F. , Glass Kathryn , Williamson Deborah A. , Polkinghorne Benjamin G. , Ingle Danielle J. , Wright Rose , Kirk Martyn D. 
Published: March 2023

Shigellosis is an increasing cause of gastroenteritis in Australia, with prolonged outbreaks reported in remote Aboriginal and Torres Strait Islander (hereafter “First Nations”) communities and among men who have sex with men (MSM) in major cities. To determine associations betweenShigellaspecies and demographic and geographic factors, we used multivariate negative binomial regression to analyse national case notifications of shigellosis from 2001 to 2019.Between 2001 and 2019, Australian states and territories reported 18,363 shigellosis cases to the National Notifiable Diseases Surveillance System (NNDSS), of which age, sex and organism information were available for >99% (18,327/18,363) of cases. Of the cases included in our analysis, 42% (7,649/18,327) wereS.sonnei, 29% (5,267/18,327) wereS.flexneri, 1% (214/18,327) wereS.boydii, less than 1% (87/18,327) wereS.dysenteriae, and species information was unknown for 28% (5,110/18,327) of cases. Males accounted for 54% (9,843/18,327) of cases, and the highest proportion of cases were in children aged 0–4 years (19%; 3,562/18,327). Crude annual notification rates ranged from 2.2 cases per 100,000 in 2003 and 2011 to 12.4 cases per 100,000 in 2019. Nationally, notification rates increased from 2001 to 2019 with yearly notification rate ratios of 1.04 (95% CI 1.02–1.07) forS.boydiiand 1.05 (95% CI 1.04–1.06) forS.sonnei. Children aged 0–4 years had the highest burden of infection forS.flexneri,S.sonneiandS.boydii; and males had a higher notification rate forS.sonnei(notification rate ratio 1.24, 95% CI 1.15–1.33). First Nations Australians were disproportionately affected by shigellosis, with the notification rate in this population peaking in 2018 at 92.1 cases per 100,000 population. Over the study period, we also observed a shift in the testing method used to diagnose shigellosis, with culture independent diagnostic testing (CIDT) increasing from 2014; this also coincided with an increase in notifications of untypedShigella. This change in testing methodology may have contributed to the observed increase in shigellosis notifications since 2014, with CIDT being more sensitive than culture dependent testing methods.The findings of this study provide important insights into the epidemiological characteristics of shigellosis in Australia, including identification of high-risk groups. This can be used to inform public health prevention and control strategies, such as targeted communication programs in First Nations communities and places with high levels of interaction between young children, such as childcare centres. Our study findings also highlight the implications of culture independent testing on shigellosis surveillance, particularly a reduction in the availability of species level information. This emphasises the continued importance of culture dependant testing for national surveillance of shigellosis.
RNA sequencing-based transcriptome analysis of granulosa cells from follicular fluid: Genes involved in embryo quality during in vitro fertilization and embryo transfer
Authors: Yu Eun Jeong , Choi Won Yun , Park Mi Seon , Eum Jin Hee , Lee Dong Ryul , Lee Woo Sik , Lyu Sang Woo , Yoon Sook Young 
Published: March 2023

Background
Granulosa cells play an important role in folliculogenesis, however, the role of RNA transcripts of granulosa cells in assessing embryo quality remains unclear. Therefore, we aims to investigate that RNA transcripts of granulosa cells be used to assess the probability of the embryonic developmental capacity.

Methods
This prospective cohort study was attempted to figure out the probability of the embryonic developmental capacity using RNA sequencing of granulosa cells. Granulosa cells were collected from 48 samples in good-quality embryo group and 79 in only poor- quality embryo group from women undergoing in vitro fertilization and embryo transfer treatment. Three samples from each group were used for RNA sequencing.

Results
226 differentially expressed genes (DEGs) were related to high developmental competence of embryos. Gene Ontology enrichment analysis indicated that these DEGs were primarily involved in biological processes, molecular functions, and cellular components. Additionally, pathway analysis revealed that these DEGs were enriched in 13 Kyoto Encyclopedia of Genes and Genomes pathways. Reverse transcription quantitative polymerase chain reaction verified the differential expression of the 13 selected DEGs. Among them,10 genes were differently expressed in the poor-quality embryo group compared to good-quality embryo group, including CSF1R, CTSH, SERPINA1, CYP27A1, ITGB2, IL1β, TNF, TAB1, BCL2A1, and CCL4.

Conclusions
RNA sequencing data provide the support or confute granulosa expressed genes as non-invasive biomarkers for identifying the embryonic developmental capacity.
Os discursos do Turismo e o desafio da sua tradução
Authors: Carreira Vivina Almeida , Plag Cornelia , Carapinha Conceição 
Published: March 2023

Este volume reúne oito textos que se situam na encruzilhada entre os estudos do Turismo e da Tradução, salientando os desafios que se colocam numa área marcada pelo contacto de culturas, línguas, discursos.&amp;lt;br&amp;gt;Os trabalhos aqui compilados abarcam diferentes línguas, diferentes perspetivas teóricas, diferentes géneros textuais, e problemas de tradução. Neste âmbito, destaca-se, como uma das linhas de força deste volume, a abordagem do Turismo e da Tradução no contexto português. Ressaltam ainda os estudos sobre temáticas específicas, como é o caso do turismo cultural, nomeadamente o enoturismo, sobre a comunicação das narrativas do Turismo em catálogos ou podcasts de viagem ou, ainda, a questão da acessibilidade aos bens culturais e o papel que cabe à Tradução neste contexto.
PLANOS DIRETORES E O CONTEXTO REGIONAL: EVIDÊNCIAS A PARTIR DOS DEZ MUNICÍPIOS MAIS POPULOSOS DE MINAS GERAIS
Authors: Diniz Alexandre Magno Alves 
Published: March 2023

Este estudo parte da inquietação causada pela ausência de conteúdos regionais nos Planos Diretores de grande parte dos municípios mineiros. Visando a ilustrar a extensão dessas omissões, realizou-se uma análise dos Planos Diretores dos dez municípios mais populosos de Minas Gerais. Concomitantemente, analisaram-se os principais manuais de construção de Planos Diretores, nos quais a presença de dimensões e indicadores que deveriam compor a construção de diagnósticos municipais foi identificada, com destaque para a capacidade institucional; cultura; desenvolvimento econômico; desenvolvimento social; dinâmica imobiliária; estrutura fundiária; evolução histórica da cidade/município; infraestrutura urbana; meio ambiente; população (mobilidade e circulação); saneamento; e uso do solo. Partindo da necessidade de incorporação do contexto regional dos municípios à construção dos Planos Diretores, este estudo analisa o potencial de utilização dos dados disponibilizados pelo Índice Mineiro de Responsabilidade Social (IMRS) na caracterização do contexto regional dos municípios mineiros, oferecendo uma cesta de indicadores produzidos e disponibilizados gratuitamente pela Fundação João Pinheiro. A adoção desses indicadores e o foco na perspectiva regional ampliarão sensivelmente o poder dos Planos Diretores, fazendo cumprir de modo mais assertivo os pressupostos presentes no Estatuto das Cidades.
Multicenter study to compare the diagnostic performance of CLIA vs. FEIA transglutaminase IgA assays for the diagnosis of celiac disease
Authors: Castelijn Daan A.R. , Mulder A.H. Leontine , van der Pol Pieter , Hollander Jolien C. , Kuiper Tietie , Bijnens Caroline , Damoiseaux Jan , Bontkes Hetty J. 
Published: March 2023

Abstract

Objectives
Celiac disease (CD) is an immune-mediated enteropathy driven by gluten intake. Presence of tTG-IgA antibodies is important for the diagnosis. However, different tTG-IgA assays are used and test performance may vary. Therefore, a retrospective multicenter study was performed to compare the diagnostic performance of three assays.

Methods
The fluorescence enzyme-linked immunoassay (FEIA) EliA Celikey IgA (Phadia), the chemiluminescence immunoassays (CLIA) h-tTG IgA QUANTA Flash® (Inova Diagnostics) and the anti-tTG ChLIA IgA (Euroimmun) were compared. Diagnostic samples from CD cases (95 adults; 65 children) and controls (479 adults; 253 children) were included. Samples were blinded and reanalyzed on all platforms.

Results
A high quantitative correlation between platforms was found (p<0.0001). Both CLIA were more sensitive (adults 100%; children 100%) compared to the FEIA (adults 88.4%; children 96.6%). Specificity of all assays was high (≥97.6%) with the FEIA having the highest specificity. A cut-off based on receiver operator characteristic analysis (6.5 U/mL) improved the sensitivity of the FEIA (adults 95.8%; children 100%) without affecting specificity. Cut-off values for the CLIA assays did not need further optimization. With the FEIA, 71% of pediatric cases had a tTG-IgA level ≥10× upper limit of normal compared to 91 and 92% with QUANTA Flash and ChLIA, respectively.

Conclusions
All platforms have high diagnostic accuracy. The CLIA assays are more sensitive compared to the FEIA assay. A lower cut-off for the FEIA improves diagnostic performance, particularly in adult cases that, as demonstrated in this study, present with lower tTG-IgA levels compared to pediatric cases.
A novel electrochemical micro-titration method for quantitative evaluation of the DPPH free radical scavenging capacity of caffeic acid
Authors: Li Xiaofen , Yang Zhi , Gao Yuntao , Xiong Huabin 
Published: March 2023

Abstract
In this report, the stoichiometric ratio (R) for the interaction of diphenylpicrylhydrazyl (DPPH) radicals with the antioxidant was employed as an evaluation index for the DPPH radical scavenging activity of antioxidants. This evaluation index was related only to the stoichiometric relationship of DPPH radicals with the antioxidant and had no relationship with the initial DPPH amount and the sample volume, which could offer a solution to the problem of poor comparability of EC50 values under different conditions. A novel electrochemical micro-titration method was proposed for the determination of the stoichiometric ratio (R) for the interaction of DPPH radicals with the antioxidant. This electrochemical micro-titration model was verified using caffeic acid as the DPPH radical scavenger, with the stoichiometric ratio (R) of DPPH radicals to caffeic acid determined to be in the range of 2.003–2.046. The calculated EC50 values were 0.513, 1.011, and 1.981 × 10–5 mol/L for 2.10, 4.05, and 8.02 × 10–7 moL of added DPPH radicals, respectively. The proposed method showed no differences from the conventional method, but had better precision and reliability, and used a smaller amount of sample.
On the stochastic integral representation of Brownian functionals
Authors: Namgalauri Ekaterine , Purtukhia Omar 
Published: March 2023

Abstract
In this paper, we study the question of representing one class of Brownian functionals as a stochastic Itô integral with an explicit form of the integrand. The considered class of functionals also includes functionals that are not smooth in the sense of Malliavin, to which both the well-known Clark–Ocone formula (1984) and its generalization, the Glonti–Purtukhia formula (2017), are inapplicable.
Size-Effects on the VHCF Response of Flat Metallic Specimens for Automotive Applications: Analysis of Fatigue Data with a Method Based on the Stress Gradient
Authors: Tridello Andrea , Boursier Niutta Carlo , Berto Filippo , Paolino Davide Salvatore 
Published: March 2023

Abstract
The design against fatigue failures at very high number of cycles (VHCF) is fundamental to guarantee the integrity of components used in structural applications (aerospace, energy production, automotive). Experimental tests to assess the VHCF response of materials are generally carried out on small specimens with sizes that are significantly different from those of the components to be designed. Size-effect, which is widely known to affect the VHCF response, must therefore be properly modeled and accounted when components are designed to ensure their structural integrity. Size-effects in VHCF have been generally investigated by testing specimens with circular cross-sections and modeled by considering the probabilistic increment of the defect size with the loaded volume. In the present paper, ultrasonic fatigue tests have been carried out on hourglass flat specimens and larger dog-bone flat specimens to investigate size-effects. One aluminum alloy and four steels used for automotive applications have been tested. The experimental results have been analyzed with an innovative statistical model based on the weakest-link principle and on the stress gradient within the specimens, which does not require the size of the defect at the origin of the fatigue failure, generally not available if the specimen fails from the surface. Size-effects were found to significantly influence the VHCF response of the investigated materials, further confirming that it is strongly material dependent, even for flat specimens. A general rule for size-effect in VHCF of flat specimens was not found, proving that it must be properly experimentally verified and safely accounted when designing large components against VHCF failure.
Features of Supplemental Feeding Implementation and Physical Development of Infants
Authors: Tkach Yulia O. , Levchuk Larisa V. 
Published: March 2023

Background. Balanced feeding with timely supplemental feeding implementation ensures optimal rates of physical and psychomotor development. It is the most effective way for preventing chronic non-communicable diseases and programming health during human life.Objective. The aim of the study is to analyze the timing of the supplemental feeding administration in infants regarding their physical development.Methods. Online questionnaire was developed via Google Forms. Responses from mothers of 108 children aged from 5 months to 3 years were analyzed. Physical development was evaluated via the WHO Anthro program.Results. The timing of first supplemental feeding implementation corresponded to the Optimizing program on infants feeding in Russian Federation (2019) in 89.8% (n = 97) of cases, after 6 months — 6.5% (n = 7) of cases, and before 4 months — 3.7% (n = 4) of cases. The first supplemental feeding most commonly was vegetable puree (65.7%; n = 71), less often — porridge (18.5%; n = 20), or fruit puree (13.9%; n = 15). The meat puree was implemented after 8 months in 57.4% (n = 62) of cases. The mean of z-score for the body mass index to age ratio in children with late supplemental feeding implementation was − 1.1 ± 0.58. It has turned out to be significantly lower than in case of timely administration: 0.08 ± 0.11; p ≤ 0.05.Conclusion. Late supplemental feeding administration (especially foods with high biological value) resulted in nutritional status violation through body weight deficiency in children both on breastfeeding and formula feeding.