bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Home and Community-Based Services and Loneliness in Older People with Functional Limitations
Authors: Zhang Jinxin , Sun Xiaojie , Yao Aaron 
Published: June 2023

Abstract

Background Loneliness is one of the major health problems among older adults. Home and community-based services (HCBS) have become increasingly popular. Despite their health benefits, little is known about the relationship between HCBS use and loneliness in older people with functional limitations. Here, we aim to explore the characteristics of loneliness among older people with functional limitations and examine the association between HCBS use and loneliness in China. Methods We used data from the 2018 Health and Retirement Longitudinal Study, which includes a nationally representative sample of Chinese residents aged 65 and older with functional limitations. Logistic regression models were used to examine the associations between HCBS use and loneliness, and we further used propensity score matching to account for the potential selection. Result In China, 46% of functionally limited older adults felt lonely and only 22% of functionally limited older adults reported using HCBS in 2018. Compared with participants who did not receive HCBS, those who received HCBS were less likely to report loneliness (OR = 0.81, 95% CI = 0.63, 0.99,p = 0.048), and the results remained significant after adjusting for confounding using propensity score matching. Conclusion Our results showed that loneliness was common among functionally impaired older people in China, and the proportion of HCBS use was low. There was robust evidence to support that among people with functional limitations, HCBS use was associated with less loneliness. Further policies should promote the development of broader HCBS use for older people with functional impairments to reduce their loneliness.
Forest carbon stock budget development following extreme drought- induced dieback of coniferous stands in Central Europe – a CBM-CFS3 model application
Authors: Cienciala Emil , Melichar Jan 
Published: May 2023

Abstract

Background
The aim of this contribution is to analyze the forest carbon budget development following the recent historically unprecedented dieback of coniferous stands in the Czech Republic. The drought-induced bark-beetle infestation resulted in record-high sanitary logging, turning the Czech forestry from a long-term carbon sink offsetting about 6% of the country's greenhouse gas (GHG) emissions since 1990 to a significant source of CO2 emissions in recent years (2018–2021). In 2020, the forestry sector accounted for almost 10% of the country's overall GHG emissions. Using the nationally calibrated Carbon Budget Model of the Canadian Forest Sector at a regional spatial resolution, we analyzed the trend and scenarios of forest carbon budget development until 2070. Two critical points arise: the short-term prognosis for reducing current emissions from forestry and the implementation of adaptive forest management focused on tree species change and sustained carbon accumulation.
Results
This study used four different scenarios to assess the impact of adaptive forest management on the forest carbon budget and CO2 emissions, tree species composition, harvest possibilities, and forest structure in response to the recent calamitous dieback in the Czech Republic. The model analysis indicates that the Czech forestry may stabilize by 2025, or at the latest, by the end of this decade. Subsequently, it may become a sustained sink of about 3 Mt CO2 eq./year (excluding contribution of harvested wood products), while enhancing forest resilience by the gradual implementation of necessary adaptation measures that ensure the provision of all expected forest functions to society. The speed of adaptation is linked to harvest intensity and severity of the current calamity. Under the most severe black scenario, the proportion of unstable spruce stands declines from the current 43% to approximately 25% by 2070, in favor of more suited tree species such as fir and broadleaves. These species would also constitute about 50% of the harvest potential, while maintaining levels generated by the Czech forestry prior to the current calamity.
Conclusion
The results show progress of stabilizing CO2 emissions, implementing tree species change, and quantifying the expected harvest and mitigation potential in Czech forestry until 2070.
Bifurcation studies, chaotic pattern, phase diagrams and multiple optical solitons for the (2+1)-dimensional stochastic coupled nonlinear Schrödinger system with multiplicative white noise via Itô calculus
Authors: Tang Lu 
Published: June 2023

Abstract

The stochastic coupled nonlinear Schrödinger systems are very important equations which can be wildly used in the fields of the optical-fiber communications, nonlinear optics, plasma physics, ecological system, statistical mechanics and so on. This work mainly focuses on dynamical behavior, phase portraits, chaotic behavior and multiple optical solitons for the (2+1)-dimensional stochastic coupled nonlinear Schrödinger system with multiplicative white noise. Here, we analytically deduced bright solitons, dark solitons and periodic solutions through the bifurcation theory. Additionally , some other bounded traveling wave solutions which include Jacobi elliptic function solutions, trigonometric function solutions, rational function solutions, hyperbolic function solutions and solitary wave solutions are also obtained by using the symbolic computation as well as the complete discriminant system method. It is worth noting that we give the classification of all single traveling wave solutions at the same time. Finally, in order to further explore the propagation of the (2+1)-dimensional stochastic coupled nonlinear Schrödinger system in nonlinear optics, three-dimensional, two-dimensional, density graphs and contour graphs are also given.
Shift Scheduling for Railway Corrective Maintenance Personnel Balancing
Authors: GENÇER Muhammed Abdullah , ALAKAŞ Hacı Mehmet , EREN Tamer 
Published: May 2023

Abstract
Railway maintenance costs have gained more importance compared to previous years, with the increase in global energy costs in recent years. The personnel who directly affect the maintenance costs also constitute an important part of the costs. Therefore, maintenance personnel planning, personnel productivity, and suitability of their qualifications for maintenance work are very important. In this study, the maintenance personnel problem of Ankara Metro, where almost 4 thousand train maintenance activities occur annually for 16 main faults and 108 sub-fault types, is discussed. The qualifications and competencies of the personnel have been evaluated according to the fault types and it has tried to assign suitable personnel for maintenance works. In addition, while the maintenance durations have been evaluated together with the personnel productivity, maintenance activities have been carried out during the shift periods. To meet the expectations of maintenance personnel and increase their productivity, the Goal Programming method has been used, which allows us to achieve multiple goals. As a result of the solution, shift wages and total working times were balanced. It is thought that this study, in which personnel qualifications and expectations are evaluated together with their maintenance periods, will contribute to the literature.
Whole-exome sequencing reveals mutational profiles of anorectal and gynecological melanoma
Authors: Wei Sun , Liu Kunyan , Zhao Fang , Zhou Hongyu , Dong Yan , Xu Yu , Kong Yunyi , Wang Minghe , Xi Cheng , Chen Yong 
Published: May 2023

Abstract
Mucosal melanoma is a rare and highly malignant type of melanoma. Among the sites that mucosal melanoma arises, anorectal and gynecological melanoma has more aggressive behavior and worse prognosis. There was no effective therapy for mucosal melanoma at present. Only a small number of mucosal melanoma patients which harbor mutations in BRAF or KIT benefit from targeted therapy. So it’s an urgent need to identify more actionable mutations in mucosal melanoma. To identify more potential therapeutic targets in mucosal melanoma, 48 samples were collected from 44 patients with anorectal or gynecological melanoma and subjected to whole-exome sequencing. The tumor mutation burden was low with a median of 1.75 mutations per Mb. In chromosomal level, 1q, 6p and 8q of mucosal melanoma were significantly amplified while 9p, 10p, 10q, 16p and 16q were significantly deleted. Muc16 was the most frequently mutated oncogene in our samples(25%). The mutation frequency of KIT(20%) was comparable to the "triple-wild" genes-NRAS(20%), NF1(20%) and BRAF(11%). KMT2D mutation was found in 18.18% patients, which is previously unidentified. MAPK signaling pathway and lysine degradation were the most frequently mutated pathways. Moreover, patients with TP53 mutations tend to have worse clinical outcome (median survival time 19 vs. 50 months, log-rank P = 0.006). M 2000 ore mutated genes involved in MAPK signaling pathway were identified, which expand the patients potentially benefit from ample MAPK inhibitors. KMT2D could be a potential therapeutic target. Moreover, TP53 could be a potential prognosis marker for mucosal melanoma.
Reaction of Epichlorohydrin with 2-aryl-4,5-dimethyl-1-hydroxy imidazole: A Combined DFT and Experimental Study
Authors: Behera Subham , Kumari Priyamvada , Panda Madhusmita Priyadarsini , Sangma Simon Watre , Bhunia Sabyasachi , Padhy Arun Kumar 
Published: June 2023

Abstract
This pandemic situation has made us to understand that we need to have look for more potential anti-viral agents in order to combat the SARS virus. During this period many existing anti-viral agents are directly being used to find their efficacy or being modified to increase their efficacy. In an ongoing effort to discover a noble series of imidazole-based epoxides, which can act as synthon for the synthesis of β-Amino alcohols, were designed and synthesized using a mild, efficient, and metal free approach starting from N1-hydroxy-2,4,5-trisubstituted-imidazoles and epichlorohydrin as precursor compound which may have higher potential to show biological activity. To support the experimental finding, we have performed Density Functional Theory (DFT) calculation. On the basis of the experimental findings and theoretical calculation we have drawn the reaction pathway that led to the product formation.
Integrated analysis of microRNA and messenger RNA expression profiles reveals functional microRNA in infectious bovine rhinotracheitis virus-induced mitochondrial damage in Madin-Darby bovine kidney cells
Authors: Ma Yingcai , Guo Xueping , He Qin , Liu Lu , Li Zelong , Zhao Xiaomin , An Feitong , Gu Wenxi , Zhong Qi , Li Na , Yao Gang , Ma Xuelian 
Published: May 2023

Abstract
Background
Studies have confirmed that Infectious bovine rhinotracheitis virus (IBRV) infection induces mitochondrial damage. MicroRNAs (miRNAs) are a class of noncoding RNA molecules, which are involved in various biological processes and pathological changes associated with mitochondrial damage. It is not known whether miRNAs participate in IBRV-induced mitochondrial damage in Madin-Darby bovine kidney (MDBK) cells.
Results
In the present study, we used high-throughput sequencing technology, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis to screen mitochondria-related miRNAs and messenger RNAs (mRNAs). In total, 279 differentially expressed miRNAs and 832 differentially expressed mRNAs were identified in 6 hours (IBRV1) versus 24 hours (IBRV2) after IBRV infection in MDBK cells. GO and KEGG enrichment analysis revealed that 42 differentially expressed mRNAs and 348 target genes of differentially expressed miRNAs were correlated with mitochondrial damage, and the miRNA-mitochondria-related target genes regulatory network was constructed to elucidate their underlying regulatory relationships. The expression patterns of eight of ten differentially expressed miRNAs were consistent with the high-throughput sequencing results, Functional validation results showed that the overexpression of miR-10a and miR-182 aggravated mitochondrial damage and that the inhibition of miR-10a and miR-182 alleviated mitochondrial damage.
Conclusions
This study revealed not only the expression changes of miRNAs and mRNAs in IBRV-infected MDBK cells but also the possible biological regulatory relationship between them. MiR-10a and miR-182 have the potential to be developed as biomarkers for IBRV diagnosis and treatment. Together, these data and analyses provide additional insight into the role of miRNAs and mRNAs in IBRV-induced mitochondria damage.
Sediment thickness of subsurface anomalous Sources Determined by 2D/3D modeling of Potential field Gravity data: Implications for Sokoto Inland Basin Structures, NW, Nigeria
Authors: Abubakar Adamu , Likkason Othniel Kamfani , Maigari Abubakar Sadiq , Ali Sani 
Published: June 2023

Abstract

Due to the promising potential for hydrocarbon exploration in Nigeria's inland basin, more and more emphasis is being paid to the structural setting associated with these basins, especially the current Sokoto basin. Lacoste and Romberg's CG-725 gravimeter collected a sizable amount of potential field gravity data for relative measurements in the region, which is used in this work. The depth of the Earth's subsurface was investigated in this study, which also provided information on the most likely process of emplacement for the bodies that gave rise to the anomalous structures in the Sokoto inland basin. The regional field, a plane with a gradient of 0.38 mG/km and an approximate 10° northeasterly dip, was used as a technique for regional-residual separation. The relative amplitudes of the negative Bouguer gravity anomaly in the region range from − 27.38 mGal to -74.88 mGal. In the southern part of the study area, a large positive anomaly with amplitude of 16.2 mGal can be detected on the residual anomaly map. The main techniques for applying enhancement filters include 2D forward modeling, analytical signal and tilt of angle derivative, directional filtering, power spectrum analysis, Werner deconvolution, and 3D inversion. The 2D spectral depth analysis of gravity data along the rift axis (NE-SW) indicates that source depths tend to deepen toward the south. The joint 2D forward modeling of gravity data provided more evidence for this, demonstrating that the top of the basement slopes both in the NW-SE and N-S directions. The 3D gravity model's findings concur with those derived from methods for estimating depth and surface geological properties. Two depth estimates—1.8 km and 2.93 km—that roughly match the locations of two density boundaries were obtained using the gravitational power spectrum analysis. In the up-dip parts of the Taloka and Gundumi-Illo Formations, intrusions were found at depths of 10–20 km and 5–10 km, respectively, according to gravity modeling of the upper crust. The quaternary faults and fractures in the Eocene sediment at Gwandu Continental Terminal are essential for the sediment cover of the regional hydrocarbon system.
Spatial planning constraints will mitigate the fragmentation trajectory of natural and semi-natural landscapes: A case of Lushan City, China
Authors: Zhang Zhiduo , He Geng , Cai Wenbo , Zhu Qing , Cai Yongli 
Published: May 2023

Abstract
Context
The biodiversity of ecosystems is under severe threat from landscape fragmentation resulting from rapid urbanization. To understand the future trajectory of landscape patterns, it is imperative to examine the impact of current spatial planning constraint policies on the preservation of natural and semi-natural landscapes, as well as the promotion of ecosystem services and sustainability.
Methods
We employed a Patch-generating Land Use Simulation (PLUS) model to simulate and predict the land use and landscape pattern alterations in Lushan City under two distinct scenarios: "Planning Constraints (PC)" and "Natural Development (ND)". Subsequently, we identified an appropriate Landscape Fragmentation Index (LFI) that effectively captures the essence of fragmentation. To determine the optimal scale, we adopted an experimental approach using both the Moving Window (MW) method and the semi-variance function. By constructing a spatiotemporal sequence of LFI and the following trend analysis, we selected the Potential Fragmentation Areas (PFA) with significant tendencies toward landscape fragmentation.
Results
The spatial planning constraints 1) would prevent the encroachment of construction land into 2.14 km2 of cropland, 0.21 km2 of forest, and 0.13 km2 of grassland; 2) shift the highly fragmented area from the northeastern portion of Lushan to the planned area defined by the development boundary; 3) will mitigate and decelerate the trend of landscape fragmentation in natural and semi-natural landscapes, decrease PFA by 7.74 km2 and preserve 15.61 km2 of natural landscapes.
Conclusions
Spatial planning constraints have effectively controlled the expansion of the construction land. This control mechanism has greatly protected natural and semi-natural landscapes and ensured the conservation of habitats. Moreover, it provides an opportunity to incorporate landscape fragmentation risk considerations into future eco-management optimization.
The Application of Computer Virtual Reality Technology in Dance Movement Analysis
Authors: Li Lei 
Published: May 2023

Abstract
With the development of virtual reality systems for dance movements. Do a simple grooming. Designed a virtual reality system for Tai Chi exercise training. The system will generate virtual images of Tai Chi coaches and learners. Learners can observe the coach's images and imitate their movements until their own virtual images in the system and coaches. until the video action is consistent. New science and technology play an increasingly important role, and big data, artificial intelligence and virtual reality technology gradually penetrate into the daily life process. Due to the requirements of comprehensive quality education proposed by the overall national strategy, the emphasis on sports dance has gradually increased. In order to realize the diversified content expansion of sports dance, to explore the application research movements, and to excavate models with operational significance are the main strategic directions of discussion. However, due to the complex movements and repeated actions of music and dance videos, it is more difficult to conduct content-based video clip retrieval research on dance videos, and it is difficult to meet the user's requirements for video retrieval detection accuracy. The time sequence factors, granularity factors, interference factors, etc. Taking all aspects into consideration, video clips similar to the query clip are selected by comparing the similarity.
Waterborne exposure during non-consumptive domestic use of surface water: a population study across WASH service levels in rural India
Authors: Daniels Miles E. , Pradhan Ashirbad , Odagiri Mitsunori , Jenkins Marion W. 
Published: May 2023

Abstract

Exposure to pathogens from domestic use of surface water is understudied. In many low- and middle-income countries, surface water is used for hygiene, sanitation, amenity, and recreational purposes. In this study, self-reported use of and structured observations at community ponds were collected to measure waterborne exposure across water and sanitation service levels in a rural population of Khorda District, India. Overall, 86% of households (n = 200) reported using ponds on a regular basis. Among observed people (n = 765), 82% put water into their mouth at least once, with a median frequency of five occurrences per visit. Reported and observation data were combined to estimate the proportion (p) of the population that put water in their mouth at least once per day, and their mean daily rate of oral exposure (OE). These were highest for individuals with neither safely managed water nor basic sanitation access (p = 93%, OE = 14 day−1), but still high among those with both (p = 67%, OE = 6 day−1). The results suggest widespread exposure to waterborne pathogens in settings where non-potable surface water bodies continue to be used for domestic purposes, even among households with access to safely managed drinking water.
Role of Circular RNAs in Prostate Cancer
Authors: Chen Feng , Zhang Fa , Liu Yong-Qiang , Leng Yu-Fang 
Published: June 2023

Objectives:
This study aims to summarize the current literature to demonstrate
the importance of circular RNAs (circRNAs) in multiple aspects of prostate cancer (PCa)
occurrence, progression, and treatment resistance and explore the potential role in therapeutic
strategies aimed at targeting this molecule in PCa.

Methods:
The relevant literature from PubMed and Medline databases is reviewed in this
article.

Results:
Non-coding RNA has been proven to play a vital role in regulating tumor progression.
Among them, circular RNA plays a more unique role due to its nonlinear structure.
Lots of circRNAs were found to be differentially expressed in PCa and regulate cell
signaling pathways by regulating particular gene expressions. Recent studies have demonstrated
that circRNAs are associated with the chemoresistance of urinary tumors, suggesting
that circRNAs might be a novel therapeutic target and a marker for therapeutic response
and prognosis assessment.

Conclusion:
The potential crosstalk of circRNAs modifications in PCa development,
therapy, and regulation of tumor metabolism is portrayed in this review. However, more
preclinical and clinical trials of this targeted strategy are necessary for the treatment of
urinary tumors.
Dysregulation of Transfer RNA-derived Small RNAs that Regulate Cell
Activity and its Related Signaling Pathways in Human Cancers
Authors: Fang Shuai , Liu Kaitai , Huang Tianyi , Du Juan , Chen Chujia , Zheng Zhen 
Published: June 2023

Abstract:
tsRNAs are small noncoding RNAs that originate from tRNA cleavage and play important
regulatory roles in gene expression, translation, transcription, and epigenetic modification. The
dysregulation of tsRNAs in cancer disrupts gene expression and perturbs various cellular activities,
including cell proliferation, apoptosis, migration, and invasion. Moreover, tsRNAs may influence cancer
development by regulating related cell signaling pathways. In this review, we first examine the origins
and classification of tsRNAs and their effects on tumor cell activity. To highlight the latest research
progress of tsRNAs and signaling pathways, we summarize the possible mechanisms of tsRNAs
in specific tumor-related signaling pathways, including the Wnt, TGFb1, MAPK, PI3K-AKT,
Notch, and MDM2/p53 signaling pathways, that have been identified in recent research.