bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable cultivation of the white truffle (Tuber magnatum) requires ecological understanding
Authors: Čejka Tomáš , Trnka Miroslav , Büntgen Ulf 
Published: July 2023

AbstractThe white truffle (Tuber magnatumPicco.; WT) is the most expensive and arguably also the most delicious species within the genusTuber. Due to its hidden belowground life cycle, complex host symbiosis, and yet unknown distribution, cultivation of the enigmatic species has only recently been achieved at some plantations in France. A sustainable production of WTs under future climate change, however, requires a better ecological understanding of the species’ natural occurrence. Here, we combine information from truffle hunters with a literature review to assess the climatic, edaphic, geographic, and symbiotic characteristics of 231 reported WT sites in southeast Europe. Our meta-study shows that 75% of the WT sites are located outside the species’ most famous harvest region, the Piedmont in northern Italy. Spanning a wide geographic range from ~ 37° N in Sicily to ~ 47° N in Hungary, and elevations between sea level in the north and 1000 m asl in the south, all WT sites are characterised by mean winter temperatures > 0.4 °C and summer precipitation totals of ~ 50 mm. Often formed during past flood or landslide events, current soil conditions of the WT sites exhibit pH levels between 6.4 and 8.7, high macroporosity, and a cation exchange capacity of ~ 17 meq/100 g. At least 26 potential host species from 12 genera were reported at the WT sites, withPopulus albaandQuercus cerrisaccounting for 23.5% of all plant species. We expect our findings to contribute to a sustainable WT industry under changing environmental and economic conditions.
Oestrogen receptor low positive breast cancer: associations with prognosis
Authors: Skjervold Anette H. , Valla Marit , Bofin Anna M. 
Published: July 2023

Abstract
Purpose
In this study of oestrogen receptor (ER) Low Positive breast cancers (BC) in three large cohorts of BC patients, we assess associations between levels of ER expression and tumour characteristics and prognosis.

Methods
Cases were stratified into patients unlikely to have received adjuvant therapy according to treatment guidelines at time of diagnosis (before 1995), and those who could have received adjuvant therapy (diagnosed in 1995 or later). ER status was divided into < 1%; ≥ 1 < 10%; ≥ 10%. Results were correlated with time of diagnosis, histopathological grade, proliferation status, and molecular subtypes, using Pearson’s Chi-square test. For prognosis, hazard ratios and cumulative incidence of death from BC were used.

Results
Of the 1955 tumours, 65 (3.3%) were ER Low Positive (ER ≥ 1 < 10%). Overall, the highest proportion of ER Low Positive tumours was observed among Luminal B (HER2 +) subtype (9.4%) and grade 3 tumours (4.3%). The risk of death from BC was lower in ER Low Positive and ER ≥ 10% compared to ER-negative cases. Compared to patients diagnosed before 1995, women diagnosed in 1995 or later showed a higher proportion of ER Low Positive BCs, and their tumours were of smaller size, lower grade, and lower proliferative status. There was no significant difference in prognosis compared to those with ER ≥ 10% tumours.

Conclusion
Women with ER Low Positive tumours diagnosed in a time period when adjuvant therapy was available had tumours of smaller size, lower grade, and lower proliferative status, and similar prognosis to those with ER ≥ 10% compared to women diagnosed earlier.
Trauma Experience Among Women Who Have Substance Use Disorders and are Homeless or Near Homeless
Authors: Greene Alison , Korchmaros Josephine D. , Frank Franziska 
Published: July 2023

AbstractWomen with substance use disorders (SUDs) who are homeless or near homeless have high rates of mental health, behavioral health, and SUD treatment needs. To effectively respond to these needs, it is critical to understand the population-specific trauma experiences of these women. This descriptive study examined the extent and nature of trauma experience among women who have an SUD and are homeless or near homeless. Results (n = 851 women) indicated high rates of trauma experience. All participants (100%) reported at least one type of trauma experience in their lifetime, with the majority (75.3%) having experienced five to seven of the seven types of trauma experiences assessed. Participants reported high levels of emotional severity related to the majority of traumatic events experienced. The pervasiveness of the trauma experiences and the related emotional impact among women with SUDs who are homeless or near homeless reinforce the necessity for trauma-informed care in treatment settings.
Entrepreneurship as a transition to the circular economy
Authors: Fernandes Cristina I. , Veiga Pedro Mota , Ramadani Veland 
Published: July 2023

AbstractGiven the challenges facing businesses and society in mitigating climate change, creating and supporting sustainable entrepreneurship is critical. However, the influence of National Systems of Entrepreneurship (NSEs) on the circular economy has not yet been studied. Our research studies the impact of NSEs on countries' circular economies while assessing the impact of the digital transition on this relationship. Using dynamic panel econometric techniques and by using various international databases, it was possible to assess the effect of NSEs on the circular economy.
Furthermore, our analysis also allowed us to research how the impact of the digital transition may influence the relationship between NSEs and the circular economy. We achieve that countries with advanced NSEs achieve superior grades in their circular economy. We intend to add to the theoretical field by extending the knowledge of the relationship between NSEs and the circular economy. We also intend that the various actors in the surrounding environment who enhance entrepreneurial activities, realize that entrepreneurship is a fundamental component, within the system to which it belongs, for achieving the circular economy.
Randomised placebo-controlled clinical trial evaluating the impact of a new visual rehabilitation program on neuroadaptation in patients implanted with trifocal intraocular lenses
Authors: Piñero David P. , Maldonado-López Miguel J. , Molina-Martin Ainhoa , García-Sánchez Noelia , Ramón María L. , Rincón José L. , Holgueras Alfredo , Arenillas Juan F. , Planchuelo-Gómez Álvaro , Leal-Vega Luis , Coco-Martín María Begoña 
Published: July 2023

Abstract
Purpose
To evaluate the efficacy of a new visual training program for improving the visual function in patients implanted with trifocal intraocular lenses (IOLs).

Methods
Randomised placebo-controlled clinical trial enrolling 60 subjects (age, 47–75 years) undergoing cataract surgery with implantation of trifocal diffractive IOL. Home-based active visual training was prescribed immediately after surgery to all of them (20 sessions, 30 min): 31 subjects using a serious game based on Gabor patches (study group) and 29 using a placebo software (placebo group). Visual acuity, contrast sensitivity (CS), and perception of visual disturbances (QoV questionnaire) were evaluated before and after training. Likewise, in a small subgroup, resting-state functional magnetic resonance imaging (rs-fMRI) analysis was performed.

Results
No significant differences were found between groups in compliance time (p = 0.70). After training, only significant improvements in monocular uncorrected intermediate visual acuity were found in the study group (p ≤ 0.01), although differences between groups did not reach statistical significance (p ≥ 0.11). Likewise, significantly better binocular far CS values were found in the study group for the spatial frequencies of 6 (p = 0.01) and 12 cpd (p = 0.03). More visual symptoms of the QoV questionnaire experienced a significant change in the level of bothersomeness in the study group. Rs-fMRI revealed the presence significant changes reflecting higher functional connectivity after the training with the serious game.

Conclusions
A 3-week visual training program based on the use of Gabor patches after bilateral implantation of trifocal diffractive IOLs may be beneficial for optimising the visual function, with neural changes associated suggesting an acceleration of neuroadaptation.
Trial registration ClinicalTrials.gov, NCT04985097. Registered 02 August 2021, https://clinicaltrials.gov/(NCT04985097).
Binary Codes that do not Preserve Primitivity
Authors: Holub Štěpán , Raška Martin , Starosta Štěpán 
Published: July 2023

AbstractA set of words X is not primitivity-preserving if there is a primitive list of length at least two of elements from X whose concatenation is imprimitive. Here, a word or list is primitive if it is not equal to a concatenation of several copies of a shorter word or list, and imprimitive otherwise. We formalize a full characterization of such two-element sets $$\{x,y\}$$

{
x
,
y
}

in the proof assistant Isabelle/HOL. The formalization is based on an existing proof which we analyze and simplify using some innovative ideas. Part of the formalization, interesting on its own, is a description of the ways in which the square xx can appear inside a concatenation of words x and y if $$\left| y \right| \le \left| x \right| $$

y

≤

x

. We also provide a formalized parametric solution of the related equation $$x^jy^k = z^\ell $$

x
j

y
k

=

z
ℓ

.
Genetic Diversity of Cowpea Parental Lines Assembled for Breeding in Uganda
Authors: Edema Richard , Adjei Emmanuel Amponsah , Ozimati Alfred Adebo , Tusiime Sharon Mbabazi , Badji Arfang , Ibanda Angele , Dramadri Isaac Onziga 
Published: July 2023

AbstractCowpea is a grain legume that is commonly grown in Sub-Saharan Africa (SSA) for a variety of uses including food, feed, and soil fertility enhancement through nitrogen fixation. Genetic improvement in cowpea can be accomplished by creating breeding populations from high-performing but genetically diverse parental lines. The goal of this study was to use single nucleotide polymorphic markers (SNPs) to estimate genetic diversity and population stratification among cowpea parental genotypes from five countries. A total of 2,746 SNP markers were used to analyze 62 cowpea genotypes that differed in key characteristics. Only 55% of the SNP markers were polymorphic across the 62 genotypes and met the selection requirement. The gene diversity varied from 0.52 to 0.57 with an average of 0.55, while the polymorphic information content ranged from 0.46 to 0.51 with an average of 0.49, showing that the cowpea parental lines are genetically diverse. The analysis of molecular variance (AMOVA) found high significant (p < 0.001) variation among genotypes and non-significant variation across genotypes depending on country of origin. The cluster analysis for the 62 genotypes using the unweighted pair group procedure with arithmetic mean approach divided the genotypes into two distinct groups. Genotypes from the same geographical regions tended to cluster together and there was a significant level of genetic variation among genotypes from Uganda and Nigeria. The SNP markers utilized in this study were effective at distinguishing genotypes and may be used to estimate the diversity in the cowpea core collection. The genetic diversity in this collection is important for future development of improved varieties of cowpea in Uganda.
The Hypoglycemic and Hypolipidemic Effects of Polyphenol-Rich Strawberry Juice on Diabetic Rats
Authors: Gazwi Hanaa S.S. , Hassan Mohamed SH. , Ismail Hamadi A. , El-Naem Gamal F. Abd , Tony Sallam K. 
Published: July 2023

AbstractObesity and diabetes are some of the most important modern health problems requiring simple preventative or palliative measures using dietary means. This study investigated the impact of strawberry juice on diabetic rats. Diabetes was induced in rats using a single intraperitoneal injection of 50 mg/kg streptozotocin (STZ). Fifty male rats were divided into five groups: normal control (NC), strawberry juice only (S), diabetic control (DC), and two diabetic groups treated with strawberry juice (DC + S) or metformin (DC + met). Rats were administered a single dose of both strawberry juice and oral metformin, and biochemical and histological analyses were conducted. The experiment was conducted in compliance with the Ethics Committee’s regulations for the care and utilization of animals, microorganisms, and living cell cultures in education and scientific research at the Faculty of Agriculture, Minia University (MU/FA/006/12/22). Treatment of diabetic rats with strawberry juice led to a significant decrease in blood glucose. Insulin levels were also significantly increased, while lipid profiles were lowered in the diabetic rats treated with strawberry juice. Carbohydrate metabolism enzymes and antioxidant enzyme activities in the treated rats were restored to normal levels, and the levels of lipid peroxidation and proinflammatory cytokines were notably reduced. The microstructure of pancreatic and liver cells in diabetic rats was also improved with strawberry juice treatment. In addition, HPLC analysis revealed that strawberry juice was rich in flavonoids and phenolic compounds and exhibited potent antioxidant activity. These findings suggest that strawberry juice has considerable hypoglycemic and hypolipidemic effects on rats with diabetes which may be used in human after further investigations.
Paradoxes and Paradigms: elements and compounds: similar names, very different energetics
Authors: Ponikvar‑Svet Maja , Edwards Kathleen Frances , Liebman Joel Fredric 
Published: July 2023

AbstractIn this paper we continue to review the phonetic similarity of trivial names of chemical substances and the names of the elements in the periodic table. Thermochemical properties are explicitly considered. We review elements from francium (Fr) to oganesson (Og), Z = 87 to 118.
Spent coffee grounds as feedstock for the production of biosurfactants and the improved recovery of melanoidins
Authors: Moya-Ramírez Ignacio , Pegalajar-Robles María Encarnación , Debiasi Alberton Michele , Rufián-Henares José A. , Fernández-Arteaga Alejandro , Garcia-Roman Miguel , Altmajer-Vaz Deisi 
Published: July 2023

AbstractSpent coffee grounds (SCG) are wastes generated in high amounts worldwide. Their composition makes them a promising feedstock for biotechnological processes. Here we show that the production of the biosurfactant surfactin by submerged culture of a Bacillus subtilis strain growing on SCG is possible, reaching concentrations up to 8.8 mg/L when using SCG at 8.3 g/L in the medium. In addition, we report a synergy between the production of surfactin and the recovery of melanoidins, an added-value compound already present in SCG. More specifically, the concentration of melanoidins in the culture medium increased between 2.1 and 2.5 times thanks to the presence of the B. subtilis in the culture. Furthermore, we have observed a strong interaction between surfactin and melanoidin aggregates through dynamic light scattering measurements, and that both of them can be co-purified with an acid precipitation. We have also characterized the interfacial and antioxidant properties of the cell-free supernatant and surfactin extract, as well as the distribution of the congeners of the biosurfactant. Altogether, this work describes a promising approach to obtain biosurfactants and antioxidant molecules in a single operation, which can be used to design several new formulations of interest for bioremediation, amendment of soils, food and cosmetics.
Changes in glacier albedo and the driving factors in the Western Nyainqentanglha Mountains from 2001 to 2020
Authors: Ren Shaoting , Jia Li , Menenti Massimo , Zhang Jing 
Published: July 2023

AbstractGlacier surface albedo dominates glacier energy balance, thus strongly affecting the glacier mass balance. Glaciers in the Western Nyainqentanglha Mountains (WNM) experienced large mass losses in the past two decades, but long-term changes of glacier albedo and its drivers are less understood. In this study, we retrieved glacier albedo with MODIS reflectance data to characterize the spatiotemporal variability of albedo from 2001 to 2020. Air temperature, rainfall, snowfall and deposition of light-absorbing impurities (LAIs) were evaluated as potential drivers of the observed variability in glacier albedo. The results showed that: (1) the glacier albedo experienced large inter-annual fluctuations, with the mean albedo being 0.552 ± 0.002 and a clear decreasing trend of 0.0443 ± 2 × 10−4 dec−1 in the WNM. The fastest decline was observed in autumn and in the vicinity of the equilibrium line altitude, indicating an extended melt season and an expansion of the ablation region to higher elevation; (2) local meteorology and LAIs deposition are the main drivers of glacier albedo change, but their effects on seasonal albedos are different due to different glacier processes. Both air temperature and the balance between liquid and solid precipitation affect summer and autumn albedos due to glacier ablation. Air temperature is the main driver of spring and winter albedos due to sublimation and metamorphism of snow, while snowfall carried by westerlies has limited influence on these two seasonal albedos due to less snowfall. LAIs mainly affect spring albedo due to high concentration coupled with the southerly wind in spring. These findings highlight the significance of changes in glacier albedo and the key role of local meteorology and LAIs deposition in determining such changes, which play an important role in glaciological and cryosphere processes.
Chinese monks, dragons, and reincarnation: the hand of Juan Cobo in the cultural translation of Mingxin baojian 明心寶鑑 (Precious Mirror for Enlightening the Mind), circa 1590
Authors: Zhang Rachel Junlei , Gil-Osle Juan Pablo 
Published: July 2023

AbstractThis article examines the relationship between the manuscript translation of Mingxin baojian 明心寶鑑 (Precious Mirror for Enlightening the Mind) (circa 1590) by Juan Cobo (circa 1546–1592) and the Fujian book market in China. It explores the cultural implications of Cobo's translation by focusing on the commentary he provided in the marginalia of the manuscript. By investigating Cobo's translation and marginalia notes on three Chinese concepts—Chinese monks, dragons, and reincarnation—this article highlights the complex cultural issues present when the early Spanish missionaries in the Philippines negotiated with Chinese culture in their writings and publications.
Statistical Evidence for Off‐Equatorial Minimum‐B‐Pocket as a Source Region of Electron Cyclotron Harmonic Waves in the Dayside Outer Magnetosphere
Authors: Yu Jiang , Wang Jing , Chen Zuzheng , Ren Aojun , Liu Xiaoman , Liu Nigang , He Zhaoguo , Li Kun , Li Liuyuan , Cui Jun , Cao Jinbin 
Published: July 2023

AbstractThe off‐equatorial minimum‐B‐pocket (OEMBP) at high latitudes in the dayside outer magnetosphere is expected as another source region of the electrostatic electron cyclotron harmonic (ECH) waves, in addition to the magnetic equator. However, its crucial role in the excitation of the dayside ECH waves has never been directly investigated due to its spatiotemporal‐varying and difficulty to be located. Based on the observations from Magnetospheric Multiscale satellites, we statistically analyze the properties of dayside ECH waves by organizing them according to the latitude distance from the OEMBP located by the spatiotemporal‐varying geomagnetic field model. Such mapping confirms larger occurrence rates and electric field amplitudes of dayside ECH waves in the vicinity of the OEMBP, which gradually fall down nearby with the latitude distance increasing. Our results provide statistical evidence for the OEMBP as another source region of ECH waves besides the magnetic equator.
Learning from algorithm-generated pseudo-annotations for detecting ants in videos
Authors: Zhang Yizhe , Imirzian Natalie , Kurze Christoph , Zheng Hao , Hughes David P. , Chen Danny Z. 
Published: July 2023

AbstractDeep learning (DL) based detection models are powerful tools for large-scale analysis of dynamic biological behaviors in video data. Supervised training of a DL detection model often requires a large amount of manually-labeled training data which are time-consuming and labor-intensive to acquire. In this paper, we propose LFAGPA (Learn From Algorithm-Generated Pseudo-Annotations) that utilizes (noisy) annotations which are automatically generated by algorithms to train DL models for ant detection in videos. Our method consists of two main steps: (1) generate foreground objects using a (set of) state-of-the-art foreground extraction algorithm(s); (2) treat the results from step (1) as pseudo-annotations and use them to train deep neural networks for ant detection. We tackle several challenges on how to make use of automatically generated noisy annotations, how to learn from multiple annotation resources, and how to combine algorithm-generated annotations with human-labeled annotations (when available) for this learning framework. In experiments, we evaluate our method using 82 videos (totally 20,348 image frames) captured under natural conditions in a tropical rain-forest for dynamic ant behavior study. Without any manual annotation cost but only algorithm-generated annotations, our method can achieve a decent detection performance (77% in$$F_1$$F1score). Moreover, when using only 10% manual annotations, our method can train a DL model to perform as well as using the full human annotations (81% in$$F_1$$F1score).
KA-Search, a method for rapid and exhaustive sequence identity search of known antibodies
Authors: Olsen Tobias H. , Abanades Brennan , Moal Iain H. , Deane Charlotte M. 
Published: July 2023

AbstractAntibodies with similar amino acid sequences, especially across their complementarity-determining regions, often share properties. Finding that an antibody of interest has a similar sequence to naturally expressed antibodies in healthy or diseased repertoires is a powerful approach for the prediction of antibody properties, such as immunogenicity or antigen specificity. However, as the number of available antibody sequences is now in the billions and continuing to grow, repertoire mining for similar sequences has become increasingly computationally expensive. Existing approaches are limited by either being low-throughput, non-exhaustive, not antibody specific, or only searching against entire chain sequences. Therefore, there is a need for a specialized tool, optimized for a rapid and exhaustive search of any antibody region against all known antibodies, to better utilize the full breadth of available repertoire sequences. We introduce Known Antibody Search (KA-Search), a tool that allows for the rapid search of billions of antibody variable domains by amino acid sequence identity across either the variable domain, the complementarity-determining regions, or a user defined antibody region. We show KA-Search in operation on the $$\sim $$
∼
2.4 billion antibody sequences available in the OAS database. KA-Search can be used to find the most similar sequences from OAS within 30 minutes and a representative subset of 10 million sequences in less than 9 seconds. We give examples of how KA-Search can be used to obtain new insights about an antibody of interest. KA-Search is freely available at https://github.com/oxpig/kasearch.