bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of Identification and Prognostic Analysis of a Novel Immune-Related lncRNA Pair Signature and Immune Landscape in Esophageal Adenocarcinoma: A New Method Based on “Continuous Learning” Model
Authors: Yu Yang , Li Zhen , Cheng Peng , Jia Gang , Lu Chuangxin 
Published: June 2023

AbstractWith the rapid development of information technology, many medical systems have emerged one after another with the support of continuous learning. A method of medical data privacy protection and resource utilization based on continuous learning is proposed to initialize the depth model of specific medical tasks. The depth model includes feature sampling model, data review model and task expression model, Finally, the depth model is trained according to the data from n institutions in turn. This method can overcome the obstacles of data sharing. The intelligent medical system of medical knowledge sharing will greatly improve the level of existing medical technology. An increasing body of evidence suggests that long non-coding RNAs (lncRNAs) participate in various physiological processes and pathological diseases. Esophageal adenocarcinoma develops rapidly with poor prognosis and high mortality in the near and long term. Immunotargeted therapy is a research hotspot. However, it is necessary to explore the immunomodulatory molecules of esophageal adenocarcinoma and analyze their relationship with clinicopathological characteristics and prognosis. We aimed to construct a robust immune-related lncRNA signature associated with survival outcomes in esophageal adenocarcinoma. We identified an immune-related lncRNA pairs signature with prognostic value from The Cancer Genome Atlas. Differentially expressed immune-related lncRNAs (DEirlncRNAs) were identified and paired, followed by prognostic assessment using univariate Cox regression analysis. We used least absolute shrinkage and selection operator penalized Cox analysis for constructing a risk score prognostic model and drew receiver operating characteristic (ROC) curves to predict overall survival. Then, we evaluated our signature in several settings: chemotherapy, tumor-infiltrating immune cells, and immune-mediated gene expression. In total, 339 DEirlncRNA pairs were identified, 11 of which were involved in the risk score prognostic signature. The area under ROC curves representing the predictive effect for 1-, 2-, and 3-year survival rates were 0.942, 0.987, and 0.977, respectively. The risk score model was confirmed as an independent prognostic factor and was significantly superior to clinicopathological characteristics. Correlation analyses showed disparities in drug sensitivity, tumor-infiltrating immune cells, and immune-related gene expression. We identified a novel prognostic immune-related lncRNA pair signature for esophageal adenocarcinoma. The risk score-based groups displayed different immune statuses, drug sensitivity, and immune-mediated gene expression. These findings may offer insights into the prognostic evaluation of esophageal adenocarcinoma and may provide a basis for creating personalized treatment plans.
Muscle herniation following single-port video-assisted thoracoscopic surgery: A case report
Authors: Kakamad Fahmi H. , Amin Bnar J. Hama , Tahir Soran H. , Omer Choman Sabah , Rashid Rezheen J. , Latif Alaa B. , Baba Hiwa O. , Mohammed Rebaz Omer , Abdalla Berun A. , Abdalla Sarhang Sedeeq 
Published: June 2023

Abstract

Introduction and importance
Single-port video-assisted thoracoscopic surgery is a less invasive approach for patients undergoing a bullectomy. This report demonstrates a case of post-single-port video-assisted thoracoscopic surgery of rhomboid muscle herniation into the thoracic cavity.

Case presentation
A 35-year-old lady presented with a 1-month history of dyspnea due to single large lung bullae of 13 cm × 10 cm. She underwent bullectomy using single-port video-assisted thoracoscopic surgery and recovered well thereafter. Four months later, the patient presented with pain at the site of the incision with a severe cough. During the workup, radiographic images showed herniation of the rhomboid major muscle into the thoracic cavity.

Clinical discussion
Intercostal herniation of thoracic soft tissues can be in the form of lung herniation or inverted intercostal herniation of other soft tissues. It is an extremely rare disorder and mainly occurs after an anterior thoracotomy.

Conclusion
Muscle herniation is a rare complication following video-assisted thoracoscopic surgery. Proper closure of the wound including periosteal stitches might be necessary to prevent this complication.

Highlights
Assessment of preoperative preventive measures for pulmonary aspiration in surgical patients: A cross-sectional study
Authors: Admass Biruk Adie , Abebe Melkam Mulugeta , Arefayne Nurhusen Riskey , Temesgen Mamaru Mollalign 
Published: June 2023

Abstract

Background
Pulmonary aspiration of gastric contents is a rare but catastrophic cause of anesthesia related morbidity and mortality of surgical patients. The risk of pulmonary aspiration is high in surgical patient due to multiple factors. The aim of this study was to assess the practice of aspiration prevention and prophylaxis usage for patients prior to surgery.

Method
A cross-sectional study was conducted from 10 April 2022 to 20 April 2022. Data were collected by the direct observation and patient interview. The standards were directly changed in to questionnaire form with two integral components ‘yes’ and ‘no”. Data were entered and analyzed using statistical package of social sciences (SPSS) version 20.

Result
A total of 200 surgical patients were included with a response rate of 100%. Preoperative information provision to elective surgical patients on fasting requirements and the reason for them in advance of their procedures was implemented in 63% of the patients. The verification of fasting requirement was provided in 94% of elective patients. About 62.5% of elective surgical patients received gastrointestinal stimulants preoperatively. Metoclopromide was administered for 94% of emergency patients.

Conclusion and recommendation
The practice of preoperative fasting and administration of prophylactic agents for pulmonary aspiration is quite limited in our setup. Moreover, adherence to the recommendations of American Society of Anesthesiologist (ASA) and European Society of Anesthesiologist (ESA) was also suboptimal. We strongly recommend clinicians to use appropriate prophylactic agent to the right patient and adherence of the clinician to the local guideline on prevention of pulmonary aspiration.

Highlights
The Forecast Skill of the Summer Precipitation Over Tibetan Plateau Improved by the Adoption of a 3D Sub‐Grid Terrain Solar Radiative Effect Scheme in a Convection‐Permitting Model
Authors: Cai Shuxin , Huang Anning , Zhu Kefeng , Guo Weidong , Wu Yang , Gu Chunlei 
Published: June 2023

AbstractWe have successfully incorporated a 3‐dimensional sub‐grid terrain solar radiative effect (3D STSRE) parameterization scheme into a convection‐permitting Weather Research and Forecasting model (WRF_CPM) in this study. Impacts of 3D STSRE scheme on the ability of WRF_CPM in forecasting the precipitation in summer over the Tibetan Plateau (TP) and nearby regions with complex terrain have been systematically addressed by conducting experiments without and with the 3D STSRE scheme. Results show that the application of 3D STSRE scheme can obviously mitigate the overestimation of surface solar radiation (SSR) and rainfall over TP and nearby regions, especially over the areas with much more rugged terrain (i.e., southern TP) in the WRF_CPM without 3D STSRE scheme. Further mechanism analyses indicate that the decreased surface heating induced by the reduction of SSR reduces the intensity of the thermal‐low pressure over the TP, which leads to the diminished strength of southwesterly winds and thereafter the weaker convergence of moisture flux over the southern TP. Moreover, the weakened surface thermal forcing makes the local atmosphere more stable, suppressing the vertical water vapor transport and local convection. These effects greatly alleviate the overestimation of precipitation over the southern TP produced by the WRF_CPM without the 3D STSRE scheme.
Contrasting Responses of Surface Heat Fluxes to Tropical Deforestation
Authors: Chen Hung‐Chen , Lo Min‐Hui 
Published: June 2023

AbstractDeforestation alters the exchange of heat, moisture, and momentum between the Earth's surface and the atmosphere, which can significantly affect the surface energy balance and water budget. However, changes in surface heat fluxes in response to deforestation are diverse among multi‐model simulations. This study explores factors that might cause different changes in surface heat fluxes due to tropical deforestation with NCAR Community Land Model. The results show that the changes in surface heat fluxes are related to the mean‐state flux partitioning conditions over the deforested areas. Deforestation tends to decrease both surface heat fluxes under conditions with smaller evaporative fractions (EFs), and tends to decrease the latent heat fluxes and increase the sensible heat fluxes under conditions with greater EFs. A similar relation can be found in the Land Use Model Intercomparison Project, which indicates that the varying simulated flux partitioning conditions might contribute to the diverse changes in surface heat fluxes among models.
The Phase Response of a Rough Rectangular Facet for Radar Sounder Simulations of Both Coherent and Incoherent Scattering
Authors: Gerekos C. , Haynes M. S. , Schroeder D. M. , Blankenship D. D. 
Published: June 2023

AbstractWith radar sounders, coherent backscattering simulations from global planetary digital elevation models (DEMs) typically display a deficit in diffuse clutter, which is mainly due to the implicit assumption that roughness at scales below the resolution of the DEM is absent. Indeed, while polynomial approximations of the phase evolution across the facet allow for fast and mathematically rigorous simulators, the coarse resolution of these planetary DEMs leads to a potentially significant portion of the backscattering response being neglected. In this paper, we derive the analytical phase response of a rough rectangular facet characterized by Gaussian roughness and a Gaussian isotropic correlation function under the linear phase approximation. Formulae for the coherent and incoherent power scattered by such an object are obtained for arbitrary bistatic scattering angles. Validation is done both in isolation and after inclusion in different Stratton‐Chu simulators. In order to illustrate the different uses of such a formulation, we reproduce two lunar radargrams acquired by the Lunar Radar Sounder instrument with a Stratton‐Chu simulator incorporating the proposed rough facet phase integral, and we show that the original radargrams are significantly better‐reproduced than with state‐of‐the‐art methods, at a similar computational cost. We also show how the rough facet integral formulation can be used in isolation to better characterize subglacial water bodies on Earth.
Interplanetary Hydrogen Properties Observed From Mars
Authors: Mayyasi M. , Quémerais E. , Koutroumpa D. , Baliukin I. , Titova A. , Izmodenov V. , Clarke J. , Deighan J. , Schneider N. , Curry S. 
Published: June 2023

AbstractObservations of the Lyman‐α emissions from Interplanetary Hydrogen (IPH) atoms are made from Mars' orbit using a high spectral resolution instrument in echelle configuration. The measurements can uniquely be used to resolve IPH from planetary H emissions and to subsequently determine the brightness, velocity, and thermal broadening of the IPH flow along the instrument line of sight. Planned observations conducted during special IPH campaigns as well as serendipitous observations made of the planetary limb and a comet sighting, both upwind and downwind of the bulk IPH flow direction, are analyzed to determine these properties and to examine the variability of IPH brightness with solar activity through the declining phase of Solar Cycle 24. The results show that the IPH brightness trends with solar irradiance, the flow is fainter downwind than upwind, the IPH brightness is variable and non‐negligible compared with planetary emissions, and that deriving thermal properties of IPH requires higher spectral resolution than is presently available. A heliospheric interface model was used to simulate and further interpret the derived IPH properties. These results can improve the theoretical understanding of solar system dynamics, between the solar wind and the local interstellar medium, by providing empirical constraints to simulations of the global heliosphere from the inner boundary region near 1.6 AU and can guide the development of future interplanetary missions.
Characteristics and Mechanisms of Typhoon‐Induced Decomposition of Organic Matter and Its Implication for Climate Change
Authors: Lao Qibin , Chen Fajin , Jin Guangzhe , Lu Xuan , Chen Chunqing , Zhou Xin , Zhu Qingmei 
Published: June 2023

AbstractWe recently reported that decomposition (as a carbon source) of organic matter (OM) is the dominant process in coastal waters after typhoons, which is contrary to phytoplankton blooms (as a carbon sink) in previous studies. However, the characteristics and mechanisms of typhoon‐induced decomposition and the question whether the decomposition mainly decompose particulate OM (POM) or dissolved OM (DOM) are still unclear. To address these issues, physicochemical parameters and multiple isotopes in the northern South China Sea were investigated before and after Typhoon Merbok (2017). After the typhoon, the chlorophyll‐a (Chl‐a) level decreased (25%), whereas the upwelled bottom/sedimentary OM (SOM) increased in the nearshore due to the severe disturbance caused by the typhoon. In contrast, the Chl‐a level increased (over 3 times) offshore. Nevertheless, a positive apparent oxygen utilization value occurred in both nearshore and offshore, suggesting that decomposition of OM was the dominant biogeochemical process regardless of whether phytoplankton blooms occurred after the typhoon. The decomposed POM in the nearshore was mainly from the SOM, while the offshore was primarily from locally produced fresh phytoplankton. The decomposition of OM contributed to 66% of the total oxygen consumption in the nearshore, while it contributed to 36% (dominated by the decomposition of POM, accounting for 25%) in the offshore. This study suggests that typhoon‐induced decomposition might be dominated by POM, which is not conducive to the storage of OM in sediments. It means that the capacity of sediments as a carbon sink will be weakened under global warming (increasing typhoon events).
Antimony efflux underpins phosphorus cycling and resistance of phosphate-solubilizing bacteria in mining soils
Authors: Liu Shengwei , Zeng Jiaxiong , Yu Huang , Wang Cheng , Yang Yunfeng , Wang Jianjun , He Zhili , Yan Qingyun 
Published: June 2023

Abstract
Microorganisms play crucial roles in phosphorus (P) turnover and P bioavailability increases in heavy metal-contaminated soils. However, microbially driven P-cycling processes and mechanisms of their resistance to heavy metal contaminants remain poorly understood. Here, we examined the possible survival strategies of P-cycling microorganisms in horizontal and vertical soil samples from the world’s largest antimony (Sb) mining site, which is located in Xikuangshan, China. We found that total soil Sb and pH were the primary factors affecting bacterial community diversity, structure and P-cycling traits. Bacteria with the gcd gene, encoding an enzyme responsible for gluconic acid production, largely correlated with inorganic phosphate (Pi) solubilization and significantly enhanced soil P bioavailability. Among the 106 nearly complete bacterial metagenome-assembled genomes (MAGs) recovered, 60.4% carried the gcd gene. Pi transportation systems encoded by pit or pstSCAB were widely present in gcd-harboring bacteria, and 43.8% of the gcd-harboring bacteria also carried the acr3 gene encoding an Sb efflux pump. Phylogenetic and potential horizontal gene transfer (HGT) analyses of acr3 indicated that Sb efflux could be a dominant resistance mechanism, and two gcd-harboring MAGs appeared to acquire acr3 through HGT. The results indicated that Sb efflux could enhance P cycling and heavy metal resistance in Pi-solubilizing bacteria in mining soils. This study provides novel strategies for managing and remediating heavy metal-contaminated ecosystems.
Internet addiction and residual depressive symptoms among clinically stable adolescents with major psychiatric disorders during the COVID-19 pandemic: a network analysis perspective
Authors: Cai Hong , Zhao Yan-Jie , He Fan , Li Shu-Ying , Li Zong-Lei , Zhang Wu-Yang , Zhang Yao , Cheung Teris , Ng Chee H. , Sha Sha , Xiang Yu-Tao 
Published: June 2023

AbstractTo assess the inter-relationships between residual depressive symptoms (RDS) and Internet addiction (IA) using network analysis among clinically stable adolescents with major psychiatric disorders during the COVID-19 pandemic. RDS and IA were assessed using the Patient Health Questionnaire-9 (PHQ-9) and the Internet Addiction Test (IAT), respectively. Central symptoms and bridge symptoms in the network model were examined. A total of 1,454 adolescents met the study criteria and were included in the analyses. The prevalence of IA was 31.2% (95% CI: 28.8%-33.6%). In the network analysis, the nodes IAT15 (“Preoccupation with the Internet”), PHQ2 (“Sad mood”), and PHQ1 (“Anhedonia”) were the most central symptoms in the IA-RDS network model. Bridge symptoms included IAT10 (“Sooth disturbing about your Internet use”), PHQ9 (“Suicide ideation”), and IAT3 (“Prefer the excitement online to the time with others”). Additionally, PHQ2 (“Sad mood”) was the main node linking “Anhedonia” to other IA clusters. Internet addiction was common among clinically stable adolescents with major psychiatric disorders during the COVID-19 pandemic. Core and bridge symptoms identified in this study could be prioritized as targets for the prevention and treatment of IA in this population.
SLC43A2 and NFκB signaling pathway regulate methionine/cystine restriction-induced ferroptosis in esophageal squamous cell carcinoma via a feedback loop
Authors: Peng Hao , Yan Yuyu , He Min , Li Jinxia , Wang Lianghai , Jia Wei , Yang Lan , Jiang Jinfang , Chen Yunzhao , Li Feng , Yuan Xianglin , Pang Lijuan 
Published: June 2023

AbstractStudies have indicated dietary restriction of methionine/cystine provided a therapeutic benefit in diseases such as cancer. However, the molecular and cellular mechanisms that underlie the interaction between methionine/cystine restriction (MCR) and effects on esophageal squamous cell carcinoma (ESCC) have remained elusive. Here, we discovered the dietary restriction of methionine/cystine has a large effect on cellular methionine metabolism as assayed in a ECA109 derived xenograft model. RNA-seq and enrichment analysis suggested the blocked tumor progression was affected by ferroptosis, together with the NFκB signaling pathway activation in ESCC. Consistently, GSH content and GPX4 expression were downregulated by MCR both in vivo and in vitro. The contents of Fe2+ and MDA were negatively correlated with supplementary methionine in a dose-dependent way. Mechanistically, MCR and silent of SLC43A2, a methionine transporter, diminished phosphorylation of IKKα/β and p65. Blocked NFκB signaling pathway further decreased the expression of SLC43A2 and GPX4 in both mRNA and protein level, which in turn downregulated the methionine intake and stimulated ferroptosis, respectively. ESCC progression was inhibited by enhanced ferroptosis and apoptosis and impaired cell proliferation. In this study, we proposed a novel feedback regulation mechanism underlie the correlation between dietary restriction of methionine/cystine and ESCC progression. MCR blocked cancer progression via stimulating ferroptosis through the positive feedback loop between SLC43A2 and NFκB signaling pathways. Our results provided the theoretical basis and new targets for ferroptosis-based clinical antitumor treatments for ESCC patients.
On the role of history-dependent adsorbate distribution and metastable states in switchable mesoporous metal-organic frameworks
Authors: Walenszus Francesco , Bon Volodymyr , Evans Jack D. , Krause Simon , Getzschmann Jürgen , Kaskel Stefan , Dvoyashkin Muslim 
Published: June 2023

AbstractA unique feature of metal-organic frameworks (MOFs) in contrast to rigid nanoporous materials is their structural switchabilty offering a wide range of functionality for sustainable energy storage, separation and sensing applications. This has initiated a series of experimental and theoretical studies predominantly aiming at understanding the thermodynamic conditions to transform and release gas, but the nature of sorption-induced switching transitions remains poorly understood. Here we report experimental evidence for fluid metastability and history-dependent states during sorption triggering the structural change of the framework and leading to the counterintuitive phenomenon of negative gas adsorption (NGA) in flexible MOFs. Preparation of two isoreticular MOFs differing by structural flexibility and performing direct in situ diffusion studies aided by in situ X-ray diffraction, scanning electron microscopy and computational modelling, allowed assessment of n-butane molecular dynamics, phase state, and the framework response to obtain a microscopic picture for each step of the sorption process.
Trajectories of freshwater microbial genomics and greenhouse gas saturation upon glacial retreat
Authors: Wei Jing , Fontaine Laurent , Valiente Nicolas , Dörsch Peter , Hessen Dag O. , Eiler Alexander 
Published: June 2023

AbstractDue to climate warming, ice sheets around the world are losing mass, contributing to changes across terrestrial landscapes on decadal time spans. However, landscape repercussions on climate are poorly constrained mostly due to limited knowledge on microbial responses to deglaciation. Here, we reveal the genomic succession from chemolithotrophy to photo- and heterotrophy and increases in methane supersaturation in freshwater lakes upon glacial retreat. Arctic lakes at Svalbard also revealed strong microbial signatures form nutrient fertilization by birds. Although methanotrophs were present and increased along lake chronosequences, methane consumption rates were low even in supersaturated systems. Nitrous oxide oversaturation and genomic information suggest active nitrogen cycling across the entire deglaciated landscape, and in the high Arctic, increasing bird populations serve as major modulators at many sites. Our findings show diverse microbial succession patterns, and trajectories in carbon and nitrogen cycle processes representing a positive feedback loop of deglaciation on climate warming.