bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilirubin in wound healing: A double‐edged sword
Authors: Singla Kshitij , M P Sarath Krishnan , Bhattacharjya Aklanta , Saxena Rahul , Choudhary Nitin , Goyal Bela 
Published: September 2023

AbstractThe impact of bilirubin levels on wound healing remains a topic of controversy. The present study is a literature review that examines the impact of increased levels of bilirubin in the bloodstream on the process of wound healing. The physiological pathways and their interrelationships, as well as the relevant research publications, were comprehensively addressed in our discussion. The present study undertook a comprehensive review of the extant literature pertaining to the impact of bilirubin concentration on the process of wound healing, with particular emphasis on its association with reactive oxygen species. This scholarly article provides an overview of several studies that elucidate the mechanisms and correlation between bilirubin and the process of wound healing. The impact of bilirubin on wound healing has been observed, and it appears to function as a modulator. This review demonstrates that there exists a spectrum of bilirubin concentrations that can function as precise regulators, although this range falls under pathological hyperbilirubinemia. Further research is required to determine the precise boundary of this range. Within a certain range, bilirubin serves as a positive regulator in the process of wound healing. Beyond this range, it has the potential to function as a negative regulator.
Homeobox‐D 1 and FTO form a transcriptional–epigenetic feedback loop to promote head and neck cancer proliferation
Authors: Zhang Chunyan , Xie Linsen , Lin Zhen 
Published: September 2023

AbstractTranscription factors (TFs) and N6‐methyladenosine (m6A) modifiers are involved in tumor progression through transcriptional regulation and posttranscriptional regulation of genes, respectively. However, the crosstalk and role of these two types of gene expression regulators in head and neck squamous cell carcinoma (HNSC) remains poorly understood. In this study, we demonstrate that the TF homeobox‐D1 (HOXD1) and the m6A demethylase fat mass and obesity‐associated protein (FTO) form a positive feedback loop to promote cell proliferation and survival in HNSC. Clinically, HOXD1 expression is dysregulated in multiple cancer types and is associated with worse prognosis in patients with HNSC, stomach adenocarcinoma, uterine corpus endometrial carcinoma, and pheochromocytoma and paraganglioma. Mechanistically, FTO is overexpressed in HNSC tumor samples and positively regulates HOXD1 expression in an m6A‐dependent manner. Functionally, deficiency of HOXD1 relieved the resistance of HNSC cells to apoptosis and arrested tumor cells at the G0/G1 phase, thereby inhibiting cell growth, whereas overexpression of HOXD1 caused the opposite effect. Furthermore, HOXD1 activates the transcription of the oncogenic factor FTO by directly targeting its promoter. Downregulation of FTO mimicked the biological effect of HOXD1 knockdown on HNSC. Importantly, overexpression of HOXD1 significantly rescued the proliferation inhibition and apoptosis promotion of HNSC cells induced by deficiency of FTO. Together, our findings reveal HOXD1 as a novel prognostic predictor and a potential target for HNSC, providing mechanistic insights into the role of the HOXD1–FTO circuit in this cancer.
On the complementary nature of ANOVA simultaneous component analysis (ASCA+) and Tucker3 tensor decompositions on designed multi‐way datasets
Authors: Koleini Farnoosh , Hugelier Siewert , Lakeh Mahsa Akbari , Abdollahi Hamid , Camacho José , Gemperline Paul J. 
Published: August 2023

AbstractThe complementary nature of analysis of variance (ANOVA) Simultaneous Component Analysis (ASCA+) and Tucker3 tensor decompositions is demonstrated on designed datasets. We show how ASCA+ can be used to (a) identify statistically sufficient Tucker3 models; (b) identify statistically important triads making their interpretation easier; and (c) eliminate non‐significant triads making visualization and interpretation simpler. For multivariate datasets with an experimental design of at least two factors, the data matrix can be folded into a multi‐way tensor. ASCA+ can be used on the unfolded matrix, and Tucker3 modeling can be used on the folded matrix (tensor). Two novel strategies are reported to determine the statistical significance of Tucker3 models using a previously published dataset. A statistically sufficient model was created by adding factors to the Tucker3 model in a stepwise manner until no ASCA+ detectable structure was observed in the residuals. Bootstrap analysis of the Tucker3 model residuals was used to determine confidence intervals for the loadings and the individual elements of the core matrix and showed that 21 out of 63 core values of the 3 × 7 × 3 model were not significant at the 95% confidence level. Exploiting the mutual orthogonality of the 63 triads of the Tucker3 model, these 21 factors (triads) were removed from the model. An ASCA+ backward elimination strategy is reported to further simplify the Tucker3 3 × 7 × 3 model to 36 core values and associated triads. ASCA+ was also used to identify individual factors (triads) with selective responses on experimental factors A, B, or interactions, A × B, for improved model visualization and interpretation.
Genetic variants in the complement system and their potential link in the aetiology of type 1 diabetes
Authors: Onengut‐Gumuscu Suna , Webb‐Robertson Bobbie‐Jo M. , Sarkar Soumyadeep , Manichaikul Ani , Hu Xiaowei , Frazer‐Abel Ashley , Holers V. Michael , Rewers Marian J. , Rich Stephen S. 
Published: August 2023

AbstractType 1 diabetes is an autoimmune disease in which one's own immune system destroys insulin‐secreting beta cells in the pancreas. This process results in life‐long dependence on exogenous insulin for survival. Both genetic and environmental factors play a role in disease initiation, progression, and ultimate clinical diagnosis of type 1 diabetes. This review will provide background on the natural history of type 1 diabetes and the role of genetic factors involved in the complement system, as several recent studies have identified changes in levels of these proteins as the disease evolves from pre‐clinical through to clinically apparent disease.
Maternal overweight and obesity modify the association of serum fibroblast growth factor 21 levels with gestational diabetes mellitus: A nested case‐control study
Authors: Wu Ping , Wu Linjing , Wang Yi , Ye Yi , Yang Xue , Yuan Jiaying , Xu Jianguo , Wang Yi‐Xin , Song Xingyue , Yan Shijiao , Lv Chuanzhu , Liu Gang , Pan An , Pan Xiong‐Fei 
Published: August 2023

AbstractAimsTo examine the prospective association between fibroblast growth factor 21 (FGF21) and risk of gestational diabetes mellitus (GDM) and the modifying effect of overweight/obesity for this association.MethodsSerum FGF21 levels were measured at 6–15 weeks of gestation among 332 GDM cases and 664 matched controls. Conditional logistic regression was used to evaluate its association with GDM risk. Interaction analyses on multiplicative and additive scales were conducted to investigate the modifying effect of overweight/obesity.ResultsElevated FGF21 levels were associated with a higher risk of GDM in multivariable models, but the positive association was attenuated after further adjustment for pre‐pregnancy body mass index (BMI). A significant multiplicative interaction was noted between FGF21 (both continuous and dichotomous) and pre‐pregnancy BMI (p for interaction = 0.049 and 0.03), and the association was only significant in participants with pre‐pregnancy BMI ≥24 kg/m2. When participants were grouped based on pre‐pregnancy BMI (≥24 and <24 kg/m2) and FGF21 levels (≥median and <median), a significant association was observed in those with higher BMI and FGF21 levels (odds ratio, 2.12; 95% CI: 1.41, 3.20) but not in those with either higher BMI or higher FGF21, with a significant additive interaction (relative excess risk due to interaction = 1.23; 95% CI: 0.27, 2.20). FGF21 was also correlated with unfavourable glucose and lipid biomarkers as well as adipokines.ConclusionsElevated serum FGF21 levels in early pregnancy were associated with a higher risk of GDM, particularly among those with overweight/obesity.
Physical and mechanical properties and microstructures of submarine soils in the Yellow Sea
Authors: Tian Zhuangcai , Chang Yihua , Chen Sichao , Wang Gengchen , Hu Yanhong , Guo Chuan , Jia Lei , Song Lei , Yue Jianhua 
Published: September 2023

AbstractIn recent years, the exploration of seabed has been intensified, but the submarine soils of silt and sand in the Yellow Sea area have not been well investigated so far. In this study, the physical and mechanical properties of silt and sand from the Yellow Sea were measured using a direct shear apparatus and their microstructures were observed using a scanning electron microscope. The test results suggest that the shear strength of silt and sand increases linearly with the increase of normal stress. Based on the direct shear test, the scanning electron microscope was used to observe the section surface of sand. It is observed that the section surface becomes rough, with many “V”‐shaped cracks. Many particles appear on the surface of the silt structure and tend to be disintegrated. The X‐ray diffraction experiment reveals that the sand and silt have different compositions. The shear strength of sand is slightly greater than that of silt under high stress, which is related to the shape of soil particles and the mineral composition. These results can be a reference for further study of other soils in the Yellow Sea; meanwhile, they can serve as soil parameters for the stability and durability analyses of offshore infrastructure construction.
Hybrid zone analysis confirms cryptic species of banded newt and does not support competitive displacement since secondary contact
Authors: Kalaentzis Konstantinos , Arntzen Jan W. , Avcı Aziz , van den Berg Victor , Beukema Wouter , France James , Olgun Kurtuluş , van Riemsdijk Isolde , Üzüm Nazan , de Visser Manon C. , Wielstra Ben 
Published: August 2023

AbstractWhen two putatively cryptic species meet in nature, hybrid zone analysis can be used to estimate the extent of gene flow between them. Two recently recognized cryptic species of banded newt (genus Ommatotriton) are suspected to meet in parapatry in Anatolia, but a formal hybrid zone analysis has never been conducted. We sample populations throughout the range, with a focus on the supposed contact zone, and genotype them for 31 nuclear DNA SNP markers and mtDNA. We determine the degree of genetic admixture, introgression, and niche overlap. We reveal an extremely narrow hybrid zone, suggesting strong selection against hybrids, in line with species status. The hybrid zone does not appear to be positioned at an ecological barrier, and there is significant niche overlap. Therefore, the hybrid zone is best classified as a tension zone, maintained by intrinsic selection against hybrids. While the two banded newt species can evidently backcross, we see negligible introgression and the pattern is symmetric, which we interpret as supporting the fact that the hybrid zone has been practically stationary since its origin (while extensive hybrid zone movement has been suggested in other newt genera in the region). Our study illustrates the use of hybrid zone analysis to test cryptic species status.
Alien plant fitness is limited by functional trade‐offs rather than a long‐term increase in competitive effects of native communities
Authors: Brendel Marco R. , Schurr Frank M. , Sheppard Christine S. 
Published: September 2023

AbstractAlien plants experience novel abiotic conditions and interactions with native communities in the introduced area. Intra‐ and interspecific selection on functional traits in the new environment may lead to increased population growth with time since introduction (residence time). However, selection regimes might differ depending on the invaded habitat. Additionally, in high‐competition habitats, a build‐up of biotic resistance of native species due to accumulation of eco‐evolutionary experience to aliens over time may limit invasion success. We tested if the effect of functional traits and the population dynamics of aliens depends on interspecific competition with native plant communities. We conducted a multi‐species experiment with 40 annual Asteraceae that differ in residence time in Germany. We followed their population growth in monocultures and in interspecific competition with an experienced native community (varying co‐existence times between focals and community). To more robustly test our findings, we used a naïve community that never co‐existed with the focals. We found that high seed mass decreased population growth in monocultures but tended to increase population growth under high interspecific competition. We found no evidence for a build‐up of competition‐mediated biotic resistance by the experienced community over time. Instead, population growth of the focal species was similarly inhibited by the experienced and naïve community. By comparing the effect of experienced and naïve communities on population dynamics over 2 years across a large set of species with a high variation in functional traits and residence time, this study advances the understanding of the long‐term dynamics of plant invasions. In our study system, population growth of alien species was not limited by an increase of competitive effects by native communities (one aspect of biotic resistance) over time. Instead, invasion success of alien plants may be limited because initial spread in low‐competition habitats requires different traits than establishment in high‐competition habitats.
Ecohydrological influences of biocrusts and their pathways in a desert steppe ecosystem
Authors: Qiu Dexun , Xiao Bo , Kidron Giora J. 
Published: September 2023

AbstractBiological soil crusts (biocrusts) are a prevalent form of organic cover in drylands across the world, and they play a crucial role in shaping the ecohydrological processes and functioning of dryland ecosystems. However, in desert steppe ecosystems, the ecohydrological influences of biocrusts and their pathways have not yet been thoroughly understood. Here, we examined the influences of three types of biocrusts (cyanobacterial, cyanobacterial‐moss mixed, and moss biocrusts) on soil water retention and infiltration in a typical desert steppe of northwestern China, and we also analysed the possible pathways through which biocrusts affect them. Accordingly, the field capacity (θf, indicating soil water‐holding capacity) and saturated hydraulic conductivity (Ks, indicating soil infiltrability) of each biocrust‐covered soil and bare soil were measured both at 0–5 and 5–10 cm depths, on Arenosols (loamy sand texture) and Calcisols (silty loamy texture), respectively. Our results showed that the presence of biocrusts increased surface soil (0–5 cm) water‐holding capacity while decreased soil infiltrability, creating a remarkable impact on soil water retention and infiltration. As compared to bare soil, the θf of cyanobacterial, cyanobacterial‐moss mixed, and moss biocrusts were increased by 16.5%, 21.4%, and 21.7% on Arenosols and by 9.6%, 18.9%, and 22.8% on Calcisols, while their Ks were reduced by 43.2%, 56.2%, and 38.2% on Arenosols, and by 49.0%, 68.7%, and 36.0% on Calcisols, respectively. The development of biocrusts on sandy textured soil had a more pronounced impact on both soil water retention and infiltration than loamy textured soil. We found that biocrusts mainly changed soil water retention and infiltration by increasing the contents of clay and organic matter. More specifically, the increase in clay content led to a more significant effect compared to the increase in organic matter content on Arenosols, while the opposite influence was observed on Calcisols. Among the three types of biocrusts, the soil infiltrability of the mixed biocrusts was the lowest, perhaps due to the interaction between the accumulation of clay particles by moss and the secretion of extracellular polymeric substances by cyanobacteria. Our study highlights the remarkable ecohydrological impacts of biocrusts on desert steppe ecosystems, and the results imply that it is of great necessary to integrate biocrusts and their influences into our understanding of ecohydrological processes in global drylands.
Organometallic Reagents: Efficient Tools for the Synthesis of Fused Pyridinyl‐Lactones
Authors: Hammas Lynda , Touchet Sabrina , Adach Sandrine , Comoy Corinne 
Published: September 2023

AbstractHerein we disclose an efficient one‐pot route to a wide range of 3‐substituted fused pyridinyl‐lactones, so called aza‐phthalides. The developed strategy involves a Metal/Halogen Exchange (MHE) reaction as key step, followed by an electrophile trapping using various carbonyl derivatives and a subsequent lactonization. To promote the MHE reaction with high chemoselectivity, our investigations have particularly focused on the nature of mono‐ or bimetallic derivatives as metalation reagents including organolithiums, Grignard reagents and lithium organomagnesiate complexes, and highlighted the positive salt effect on reactional sequence. An extension to fused heteroaryl‐lactones (benzothienyl‐, benzofuranyl‐ and naphthofuranyl scaffolds) was explored.
A simplified procedure for the prediction of liquefaction‐induced settlement of offshore wind turbines supported by suction caisson foundation based on effective stress analyses and an ML‐based group method of data handling
Authors: Farahani Sina , Barari Amin 
Published: September 2023

AbstractIn this research, a series of non‐linear dynamic finite element (FE) effective stress analyses were conducted to analyze the influence of the suction caisson geometry, ground motion intensity and contact pressure caused by the offshore wind turbine (OWT) on the settlement pattern and seismic demand of the OWT's structure on saturated dense sand. The baseline model and the FE procedure were validated using a database of well‐documented centrifuge tests. However, particular attention was given to the calibration campaign based on the measured system response quantities, such as the settlement, acceleration and pore‐pressure time histories. The FE results identified the contact pressure as an important state parameter caused by the OWT's mass; the governing ground‐shaking intensity measures that play a significant role in the derivation of an analytical framework for predicting liquefaction‐induced OWT settlements during major events are the shaking intensity rate (SIR), Arias Intensity ( and spectral acceleration at a period equal to 1 s (T = 1 s). The results revealed that approximating expressions derived using the modified least‐squares method (MLSM) reasonably capture the complex phenomenon of liquefaction‐induced settlement, with some exceptions at lower SIR values. Finally, to obtain the approximating expressions, the database was combined with a machine learning (ML)‐based group method of data handling (GMDH) that appropriately describes the interplay of multiple properties of the foundation soil, structure and seismic events while incorporating the effect of the interaction between the suction caisson, foundation soil, excess pore‐pressure generation and cyclic shear stresses.
Absent drumlins beneath southern lobes of the Laurentide Ice Sheet: A new hypothesis based on Des Moines Lobe dynamics inferred from landforms
Authors: Iverson Neal R. , Krueger Sarah E. , Harding Chris 
Published: August 2023

AbstractSpatial distributions of drumlin fields encode information about ice sheet dynamics. No drumlins formed beneath the most lobate parts of the Laurentide Ice Sheet's southern margin, in South Dakota, Iowa and Illinois, whereas ice lobes to the northeast generally produced drumlins. This pattern may have resulted from northerly ice overriding permafrost. Here we propose a new hypothesis for this pattern by constructing a LiDAR‐based landform map and applying a model of drumlin formation to account for the absence of drumlins beneath the largest of the ice sheet's southern lobes, the Des Moines Lobe. Broad belts of hummocky topography, ice‐walled lake plains, doughnuts and minor moraines, which together cover 90% of the lobe's upland area in Iowa, attest to widespread ice stagnation, as does the lobe's scarcity of eskers. Most stagnation topography is subtle, with insufficient relief to have obscured drumlins that might have formed before stagnation. Minor moraines are crevasse‐squeeze ridges diagnostic of surging, and their ubiquity indicates that during surging, the lobe's soft bed was weak nearly everywhere. End moraines are generally parallel to a minor moraine setup‐glacier, implying that surge‐driven advances were more numerous than indicated by the three major end moraines of the lobe. In the only physically based model of drumlin formation that includes surging, till deposition occurs during surges when effective pressure is uniformly low, whereas drumlins develop during quiescent flow between surges, when basal slip and low‐pressure R‐channels create the spatial gradients in effective pressure necessary to sculpt drumlins by differential erosion. Landforms of the lobe, however, indicate stagnation and down‐wasting during quiescence, without significant basal slip or hydraulic potential gradients necessary for R‐channels. We hypothesize that for the three southernmost lobes of the Laurentide Ice Sheet, surging followed by widespread down‐wasting of stagnant ice prevented drumlin formation, whereas beneath northern lobes it was permitted by climatically‐forced ice advance.
Progression toward maximum leaf surface storage during the rainfall interception process
Authors: Holder Curtis D. , Lauderbaugh Leal K. 
Published: September 2023

AbstractDuring rainfall events, leaves in the canopy absorb kinetic energy from falling raindrops causing the leaves to vibrate after each individual drop impact. Additionally, intercepted water gradually increases on foliar surfaces adding greater mass exerted on each leaf. This accumulated mass of water increases the leaf inclination angle and may enable the drainage of water from the leaf surface as the water drop retention angle is surpassed. This study explored the dynamic process of leaf vibration and changes in steady‐state leaf inclination angles after raindrop impact for three species (Acer saccharinum, Quercus gambelii, and Ulmus pumila) and with four different drop sizes. An incremental increase in steady‐state leaf inclination angle was measured from processing single frames of videos as each additional raindrop impacted leaf surfaces. In general, larger drops increased leaf inclination angles to a larger degree than the smaller drops. As maximum leaf surface storage or the water drop retention angle was approached, water drained from leaf surface causing an abrupt rebound of the leaf inclination angle. The maximum changes in steady‐state leaf inclination angle before rebound (LIAmax) and the number of drops needed for leaf inclination angle rebound were significantly correlated with the initial leaf inclination angle (LIAi) for experiments with A. saccharinum and U. pumila, but not for the experiments with Q. gambelii. No significant correlations were found between LIAmax and any leaf trait (i.e., leaf area, leaf mass, petiole length, petiole diameter, leaf hydrophobicity, and water drop retention) for A. saccharinum and U. pumila; however, a significant negative correlation was found for Q. gambelii between maximum changes in leaf inclination angle and petiole diameter. Of the leaf characteristics examined, leaf surface storage is most influenced by LIAi before drop impact.