bluuebunny/crossref_metadata_2025_split huggingface dataset:
NOTCH2NLC GGC repeat expansion causes retinal pathology with intranuclear inclusions throughout the retina and causes visual impairment
Authors: Sone Jun , Ueno Shinji , Akagi Akio , Miyahara Hiroaki , Tamai Chisato , Riku Yuichi , Yabata Hiroyuki , Koizumi Ryuichi , Hattori Tomohiro , Hirose Hiroshi , Koyanagi Yoshito , Kobayashi Rei , Okada Hisashi , Kishimoto Yoshiyuki , Hashizume Yoshio , Sobue Gen , Yoshida Mari , Iwasaki Yasushi 
Published: May 2023

AbstractThe retinal pathology of genetically confirmed neuronal intranuclear inclusion disease (NIID) is yet unknown. We report the ocular findings in four NIID patients with NOTCH2NLC GGC repeat expansion to investigate the pathology of retinopathy. All four NIID patients were diagnosed by skin biopsy and NOTCH2NLC GGC repeat analysis. Ocular findings in patients with NIID were studied using fundus photographs, optical coherence tomographic images (OCT), and full-field electroretinograms (ERGs). The histopathology of the retina was studied on autopsy samples from two cases with immunohistochemistry. All patients had an expansion of the GGC repeat (87–134 repeats) in the NOTCH2NLC. Two patients were legally blind and had been diagnosed with retinitis pigmentosa prior to the diagnosis of NIID and assessed with whole exome sequencing to rule out comorbidity with other retinal diseases. Fundus photographs around the posterior pole showed chorioretinal atrophy in the peripapillary regions. OCT showed thinning of the retina. ERGs showed various abnormalities in cases. The histopathology of autopsy samples showed diffusely scattered intranuclear inclusions throughout the retina from the retinal pigment epithelium to the ganglion cell layer, and optic nerve glial cells. And severe gliosis was observed in retina and optic nerve. The NOTCH2NLC GGC repeat expansion causes numerous intranuclear inclusions in the retina and optic nerve cells and gliosis. Visual dysfunction could be the first sign of NIID. We should consider NIID as one of the causes of retinal dystrophy and investigate the GGC repeat expansion in NOTCH2NLC.
Blockchain-oriented approach for detecting cyber-attack transactions
Authors: Feng Zhiqi , Li Yongli , Ma Xiaochen 
Published: May 2023

AbstractWith the high-speed development of decentralized applications, account-based blockchain platforms have become a hotbed of various financial scams and hacks due to their anonymity and high financial value. Financial security has become a top priority with the sustainable development of blockchain-based platforms because of an increasing number of cyber attacks, which have resulted in a huge loss of crypto assets in recent years. Therefore, it is imperative to study the real-time detection of cyber attacks to facilitate effective supervision and regulation. To this end, this paper proposes the weighted and extended isolation forest algorithms and designs a novel framework for the real-time detection of cyber-attack transactions by thoroughly studying and summarizing real-world examples. Furthermore, this study develops a new detection approach for locating the compromised address of a cyber attack to resolve the data scarcity of hack addresses and reduce time consumption. Moreover, three experiments are carried out not only to apply on different types of cyber attacks but also to compare the proposed approach with the widely used existing methods. The results demonstrate the high efficiency and generality of the proposed approach. Finally, the lower time consumption and robustness of our method were validated through additional experiments. In conclusion, the proposed blockchain-oriented approach in this study can handle real-time detection of cyber attacks and has significant scope for applications.
Social–financial approach for analyzing financial transitions
Authors: Wu Xifeng , Shen Yue , Chen Jin , Chen Yu 
Published: May 2023

AbstractThis study proposes a social-financial approach (SFA) to fill the methodological research gap in strategic policy design for managing financial transitions during social changes. The SFA seeks to characterize inclusive transitions in response to innovation and analyze financial management in social changes. Using a multilevel perspective, we combine evolutionary finance and inclusive growth analytics into this framework. We contend that the interaction between the different levels can be summarized as spontaneous adjustments and the alignment of financial elements with the indicators. Actors who attempt to achieve their goals based on past performance evaluations and other forms of bounded rationality strive to cope with adjustments and further trigger a reorientation of the existing regime. We also developed a new configuration tool called the three-axis description to describe the evolution of financial transitions at different stages. These methods allow us to analyze the evolution of financial transition and efficiency, and we argue that market efficiency evolves in stages with the financial transition. Finally, to demonstrate the capability of SFA to identify diverse financial transition pathways, we examined an example case: the establishment of the Bretton Woods System.
The role of English and the sociocultural structure of Bahasa: a study of Brunei Darussalam
Authors: Morve Roshan K. , Wen Xu , Mansour Nasser 
Published: May 2023

AbstractThis paper looks at the role of English in Brunei and the sociocultural structure of Bahasa/language in Brunei Darussalam. The aim of this research is to critically analyse sociocultural theory from Vygotsky’s “peak psychology” approach and understand depth-knowledge of sociocultural theory from other scholars’ perspectives. The scholars’ views on education, language and sociocultural importance-related topics have been analysed by Barry, Goode, Jones, Haji-Othman, Sharbawi and Gardiner. These scholars’ ideas give a better understanding of the sociocultural importance of Bruneian’s individual development. For this research, a qualitative method applies and collected data is critically analysed in detail. This research has the potential to discuss the link between language evolution and Bruneian sociocultural development. The “Citizenship Acts 1961” is relevant to discuss the theoretical concepts like, ‘nationality’ and ‘ethnic identification’ from the Bruneian context. To put it in a nutshell, the ratification of “Melayu Islam Beraja” or “Malay Islamic Monarchy” and the impact of linguistic diversity in Brunei consist of a Bruneian identity. In bilingual education policy, Bahasa Melayu and English have a major role in the child development. Although a balance of regional languages and English is essential to maintain the “Bruneian” identity. Brunei is a small country but it is diverse, multilingual and multicultural.
Beyond ‘race’?: a rejoinder
Authors: Scharrer Tabea , Saharso Sawitri 
Published: May 2023

AbstractIn this rejoinder we argue, based on the papers of this commentary series, that ‘race’ is such a tricky notion because it can be used in (at least) two very different and contradictory ways—as a concept to disentangle racism and racialisation (what M’charek calls the ‘work race actually does’) and as a way of categorization and social classification, in which case it might create the very essentialised hierarchies ‘race’ as a critical concept tries to disentangle. We wonder if it is indeed possible to use ‘race’ as a concept without evoking ‘race’ as a social classification. At first, we give a short summary of the four discussion papers and then delve into two aspects the papers share, namely the need for spatial and temporal contextualization and comparison, as well as their choice not to take up our invitation to compare race as a category with gender. In a second step we will discuss two points arising from the papers, (1) ‘race’ as category, not as lens, often resulting in essentialism and (2) ‘race’ as potentially obscuring racism and racialisation. We conclude by proposing to give more space to complexity.
Bringing fictional characters to life: reflections on co-creating a comic book with members of the public
Authors: Cairns Joanne Marie , Roberts Helen , Al-Khafaji Geraldine , Kwater Maria 
Published: May 2023

AbstractThere are growing calls for cancer screening to become more personalised by considering a range of risk factors, rather than a one-size-fits-all, age-based approach. The aim of this public involvement was to co-create a comic book about bowel cancer screening to be used as a visual elicitation tool in research focus groups with members of the public and healthcare professionals, as part of the At Risk study, to discuss their attitudes toward personalised bowel cancer screening, which would involve considering different risk factors. This article critically reflects on the co-creation process to develop the comic book, benefits and challenges, and some lessons learned to inform other researchers considering a similar approach. In total, ten public contributors (5 men and 5 women) from two public involvement networks participated in two successive online workshops to develop six fictional characters, two for each level of bowel cancer risk (low, moderate and high risk). This tool was then used in the At Risk study comprising five focus groups involving 23 participants, including members of the public (n = 12) and healthcare professionals (n = 11). The co-created comic book was a generally well-received research tool able to generate discussion about a complex topic, bowel cancer risk, in an accessible way. It was suggested that the comic book may also be extended beyond the research context to inform bowel cancer screening decisions and raise awareness of risk factors.
Management and outcome of intracranial chondroma of the dural origin: case report and review of the literature
Authors: Dokponou Yao Christian Hugues , El Kacemi Inas , Imoumby Fernand Nathan , El Akroud Sofia , Salami Mohcine , Elasri Abad Cherif , Gazzaz Miloud 
Published: May 2023

Abstract
Background
The intracranial chondroma is a sporadic type of benign tumor with an incidence of less than 0.5% of all intracranial tumors. Furthermore, this type of tumor has been reported more frequently at the skull base, less at the falx cerebri, and exceptionally of the dura, when it happened to be intracranial.

Case presentation
We report a challenging diagnosis and the successful management of a rare case of intracranial dural chondroma in a 19-year-old student without past medical history, revealed by secondary epilepsy with behavioral and mood disorder without neurological deficit.

Conclusion
The dural origin of intracranial chondroma is a rare type of tumor with nonspecific clinical manifestations, and diagnosis confirmation requires a histopathological finding. Surgical gross total resection of the lesion is the golden standard of its management.
Confidential computing and related technologies: a critical review
Authors: Sardar Muhammad Usama , Fetzer Christof 
Published: May 2023

AbstractThis research critically reviews the definition of confidential computing (CC) and the security comparison of CC with other related technologies by the Confidential Computing Consortium (CCC). We demonstrate that the definitions by CCC are ambiguous, incomplete and even conflicting. We also demonstrate that the security comparison of CC with other technologies is neither scientific nor fair. We highlight the issues in the definitions and comparisons and provide initial recommendations for fixing the issues. These recommendations are the first step towards more precise definitions and reliable comparisons in the future.
Association study between rs1571801 and rs16260 with prostate adenocarcinoma predisposition in Iranian population
Authors: Rahimi Abbas , Angaji Seyed Abdolhamid , Karimi Gilda , Beikzadeh Behnaz , Roudi Raheleh , Narouie Behzad 
Published: May 2023

Abstract
Background
Prostatic adenocarcinoma is the most frequent malignancy among elderly men after lung cancer, which has the second incidence and the fourth mortality rate in the Iranian population. The primary objective of this study was to investigate how single-nucleotide polymorphisms of the CDH1 gene (rs16260) and DAB2IP (rs1571801) are associated with the risk of prostate cancer through a multi-stage approach.

Results
In the first stage of the study (58 men), we compared the genotype frequency of polymorphisms rs16260 and rs1571801 in the case group to the control group to determine significant polymorphisms (P value < 0.4). No statistically significant difference was shown between the genotype frequency of rs1571801 in the case and control groups. Thus, rs1571801 polymorphism was eliminated at this stage, and only rs16260 polymorphism evaluated in the next stage. In the second stage, statistical analysis showed a significant difference between genotype frequency of rs16260 (P value = 0.037) in all participants. The effect of rs16260 on prostate cancer was not modified by age or PSA levels. Only the Gleason Score = 7 reveals a significant difference between the risk allele (A) and the allele (C) (rs16260).

Conclusions
According to the results of this study, rs16260 is associated with prostate cancer predisposition and might be used as a potential biomarker in prostate cancer. It should be noted that these results need to be confirmed in a larger population.
Use of the Behaviour Change Wheel to design an intervention to improve the provision of mental wellbeing support within the audiology setting
Authors: Bennett Rebecca J. , Bucks Romola S. , Saulsman Lisa , Pachana Nancy A. , Eikelboom Robert H. , Meyer Carly J. 
Published: May 2023

Abstract
Objective
This study describes the development of an intervention to increase the frequency of audiologists’ asking about and providing information regarding mental wellbeing within adult audiology services.

Design
The Behaviour Change Wheel (BCW), an eight-step systematic process, was followed to develop the intervention. Reports describing the first four steps are published elsewhere. This report describes the final four steps and details the intervention developed.

Results
A multifaceted intervention was developed to change audiologists’ behaviours relating to providing mental wellbeing support to adults with hearing loss. Specifically, three behaviours were targeted: (1) asking clients about their mental wellbeing, (2) providing general information on the mental wellbeing impacts of hearing loss, and (3) providing personalised information on managing the mental wellbeing impacts of hearing loss. A variety of intervention functions and behaviour change techniques were incorporated into the intervention, including instruction and demonstration, information about others approval, adding objects to the environment, use of prompts/cues, and endorsement from credible sources.

Conclusion
This study is the first to use the Behaviour Change Wheel to develop an intervention targeting mental wellbeing support behaviours in audiologists and confirms the usability and usefulness of the approach in a complex area of clinical care. The systematic development of the Ask, Inform, Manage, Encourage, Refer (AIMER) intervention will facilitate a thorough evaluation of its effectiveness in the next phase of this work.
Ketamine and psychotherapy for the treatment of psychiatric disorders: systematic review
Authors: Kew Bess M. , Porter Richard J. , Douglas Katie M. , Glue Paul , Mentzel Charlotte L. , Beaglehole Ben 
Published: May 2023

Background
Ketamine is an effective short-term treatment for a range of psychiatric disorders. A key question is whether the addition of psychotherapy to ketamine treatment improves outcomes or delays relapse.

Aim
To identify all studies combining psychotherapy with ketamine for the treatment of psychiatric disorders to summarise their effects and make recommendations for future research.

Method
The review protocol was prospectively registered with PROSPERO (registration number CRD42022318120). Potential studies were searched for in MEDLINE, Embase, PsycINFO, SCOPUS, the Cochrane library and Google Scholar. Eligible studies combined ketamine and psychotherapy for the treatment of psychiatric disorders and did not use case reports or qualitative designs. Key findings relating to psychotherapy type, diagnosis, ketamine protocol, sequencing of psychotherapy and study design are reported. Risk of bias was assessed using modified Joanna Briggs critical appraisal tools.

Results
Nineteen studies evaluating 1006 patients were included in the systematic review. A variety of supportive individual and group, manualised and non-manualised psychotherapies were used. The majority of studies evaluated substance use disorders, post-traumatic stress disorder and treatment-resistant depression. Ketamine protocols and sequencing of ketamine/psychotherapy treatment varied substantially between studies. Outcomes were largely positive for the addition of psychotherapy to ketamine treatment.

Conclusion
The combination of psychotherapy and ketamine offers promise for the treatment of psychiatric disorders, but study heterogeneity prevents definitive recommendations for their integration. Larger randomised controlled trials using manualised psychotherapies and standardised ketamine protocols are recommended to clarify the extent to which the addition of psychotherapy to ketamine improves outcomes over ketamine treatment alone.
The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability
Authors: Shrestha Roshan L. , Balachandra Vinutha , Kim Jee Hun , Rossi Austin , Vadlamani Pranathi , Sethi Subhash Chandra , Ozbun Laurent , Lin Shinjen , Cheng Ken Chin-Chien , Chari Raj , Karpova Tatiana S. , Pegoraro Gianluca , Foltz Daniel R. , Caplen Natasha J. , Basrai Munira A. 
Published: May 2023

ABSTRACT
Restricting the localization of the evolutionarily conserved centromeric histone H3 variant CENP-A to centromeres prevents chromosomal instability (CIN). The mislocalization of CENP-A to non-centromeric regions contributes to CIN in yeasts, flies and human cells. Even though overexpression and mislocalization of CENP-A have been reported in cancers, the mechanisms responsible for its mislocalization remain poorly understood. Here, we used an imaging-based high-throughput RNAi screen to identify factors that prevent mislocalization of overexpressed YFP-tagged CENP-A (YFP–CENP-A) in HeLa cells. Among the top five candidates in the screen – the depletion of which showed increased nuclear YFP–CENP-A fluorescence – were the histone chaperones CHAF1B (or p60) and CHAF1A (or p150). Follow-up validation and characterization experiments showed that CHAF1B-depleted cells exhibited CENP-A mislocalization, CIN phenotypes and increased enrichment of CENP-A in chromatin fractions. The depletion of DAXX, a histone H3.3 chaperone, suppressed CENP-A mislocalization and CIN in CHAF1B-depleted cells. We propose that in CHAF1B-depleted cells, DAXX promotes mislocalization of the overexpressed CENP-A to non-centromeric regions, resulting in CIN. In summary, we identified regulators of CENP-A localization and defined a role for CHAF1B in preventing DAXX-dependent CENP-A mislocalization and CIN.
Prediction of Half-Life Time in Thermal Back Reaction of Photochromic Diarylbenzenes by Screening Approach
Authors: Hamatani Shota , Kitagawa Daichi , Nakahama Tatsumoto , Kobatake Seiya 
Published: May 2023

Abstract
Diarylbenzenes (DABs) have been developed as a novel family of T-type photochromic compounds. In this work, we endeavored to predict the half-life time (t1/2) in the thermal back reaction of DABs by a screening approach. By the combination of experimental and theoretical studies, we found a good relationship between the t1/2 and the activation energy estimated by theoretical calculations. Our results would provide useful information for the design of DABs having a desired thermal stability.
Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands
Authors: Walser Marc Andrea , Bachmann Nicolas , Kluckert Jonas , Köthe A. , Tully Carson , Leiser Dominic , Lomax Antony John , Bizzocchi Nicola , Langendijk Johannes Albertus , Weber Damien C 
Published: May 2023

Objectives The purpose of this study is to report the oncological outcome, observed toxicities and normal tissue complication probability (NTCP) calculation for pencil beam scanning (PBS) PT delivered to salivary gland tumour (SGT) patients. Methods We retrospectively reviewed 26 SGT patients treated with PBSPT (median dose, 67.5 Gy(RBE)) between 2005 and 2020 at our institute. Toxicities were recorded according to CTCAEv.4.1. Overall survival (OS), local control (LC), locoregional control (LRC) and distant control (DC) were estimated. For all patients, a photon plan was re-calculated in order to assess the photon/proton NTCP. Results With a median follow-up time of 46 months (range, 3–118), 5 (19%), 2 (8%), 3 (12%) and 2 (8%) patients presented after PT with distant, local, locoregional failures and death, respectively. The estimated 4 year OS, LC, LCR and DC were 90%, 90%, 87 and 77%, respectively. Grade 3 late toxicity was observed in 2 (8%) patients. The estimated 4 year late high-grade (≥3) toxicity-free survival was 78.4%. The calculated mean difference of NTCP-values after PBSPT and VMAT plans for developing Grade 2 or 3 xerostomia were 3.8 and 2.9%, respectively. For Grade 2–3 dysphagia, the grade corresponding percentages were 8.6 and 1.9%. Not using an up-front model-based approach to select patients for PT, only 40% of our patients met the Dutch eligibility criteria. Conclusion Our data suggest excellent oncological outcome and low late toxicity rates for patients with SGT treated with PBSPT. NTCP calculation showed a substantial risk reduction for Grade 2 or 3 xerostomia and dysphagia in some SGT patients, while for others, no clear benefit was seen with protons, suggesting that comparative planning should be performed routinely for these patients. Advances in knowledge We have reported that the clinical outcome of SGT patients treated with PT and compared IMPT to VMAT for the treatment of salivary gland tumour and have observed that protons delivered significantly less dose to organs at risks and were associated with less NTCP for xerostomia and dysphagia. Noteworthy, not using an up-front model-based approach, only 40% of our patients met the Dutch eligibility criteria.