bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of cell-laden multimodular Lego-like customizable endometrial tissue assembly for successful tissue regeneration
Authors: Park Se-Ra , Kook Myung Geun , Kim Soo-Rim , Lee Jin Woo , Park Chan Hum , Oh Byung-Chul , Jung YunJae , Hong In-Sun 
Published: April 2023

Abstract

Background
The endometrium, the inner lining of the uterine cavity, plays essential roles in embryo implantation and its subsequent development. Although some positive results were preliminarily archived, the regeneration of damaged endometrial tissues by administrating stem cells only is very challenging due to the lack of specific microenvironments and their low attachment rates at the sites of injury. In this context, various biomaterial-based scaffolds have been used to overcome these limitations by providing simple structural support for cell attachment. However, these scaffold-based strategies also cannot properly reflect patient tissue-specific structural complexity and thus show only limited therapeutic effects.

Method
Therefore, in the present study, we developed a customizable Lego-like multimodular endometrial tissue architecture by assembling individually fabricated tissue blocks.

Results
Each tissue block was fabricated by incorporating biodegradable biomaterials and certain endometrial constituent cells. Each small tissue block was effectively fabricated by integrating conventional mold casting and 3D printing techniques. The fabricated individual tissue blocks were properly assembled into a larger customized tissue architecture. This structure not only properly mimics the patient-specific multicellular microenvironment of the endometrial tissue but also properly responds to key reproductive hormones in a manner similar to the physiological functions.

Conclusion
This customizable modular tissue assembly allows easy and scalable configuration of a complex patient-specific tissue microenvironment, thus accelerating various tissue regeneration procedures.
Barriers to health care utilization among patients with type 2 diabetes living in slums: a qualitative study from providers' perspective
Authors: Ghammari Fawzieh , Khodayari-zarnaq Rahim , Jalilian Habib , Gholizadeh Masumeh 
Published: April 2023

Abstract
Background
Due to slum dwellers' deprivation, they are more likely to develop Type 2 Diabetes (T2D) and its complications. Type 2 Diabetes is a long-life disease that requires continuous health care utilization. One of the negative outcomes of slum-dwelling is health care underutilization. Therefore, this study aimed to understand barriers to health care utilization among those with T2D living in Tabriz slums, Iran, from the perspective of healthcare providers, in 2022.

Methods
A phenomenological approach was used in this study. Purposive sampling for conducting in-depth interviews was used to select 23 providers consisting of general practitioners, midwives, nutritionists, and public health experts. We conducted a content analysis using the 7 stages recommended by Colaizzi. We used four criteria recommended by Lincoln and Guba for ensuring the research’s trustworthiness.

Results
Three main themes and 8 categories were developed. Three main themes are 1) health care provision system barriers, including four categories: lack of motivation, non-availability of facilities and doctors, poor relationship between patients and providers, and disruption in the process 2) coverage problems, including two categories: insurance inefficiency, and limited access, and 3) contextual barriers, including two categories: environmental problems, and socioeconomic barriers.

Conclusions
Recommendations are presented in three levels to improve implementation. The health care system needs to modify the payment methods, Patients-providers relationship improvement, and increase the number of providers. Insurance organizations should consider sufficient coverage of costs for slum-dwellers with T2D and expand the benefits package for them. Government should consider infrastructure upgrading in slums to eliminate barriers related to slum-dwelling. Overall, health care utilization promotion needs intersection cooperation.
Wearable synthetic leather-based high-performance X-ray shielding materials enabled by the plant polyphenol- and hierarchical structure-facilitated dispersion
Authors: Yan Linping , Zhou Jibo , Li Hao , Zhong Rui , Zhuang Junxin , Xu Xiaohui , Wang Yaping , Liao Xuepin , Shi Bi 
Published: April 2023

AbstractEffective protection against X-ray is the premise of utilizing the X-ray, thus it is critical to develop novel X-ray shielding materials with both low density and high X-ray attenuation efficiency. As the even distribution of high-Z element components is of great significance for increasing the attenuation efficiency of X-ray shielding materials, in this study, the microfiber membrane (MFM), a type of synthetic leather featuring hierarchical structure was chosen to provide large surface area for the dispersion of rare earth (RE) element. Meanwhile, plant polyphenol was utilized to achieve the stable loading and uniform dispersion of the Ce or Er into MFM. Benefiting from the assistance of polyphenol and hierarchical structure of MFM, the even dispersion of RE element was successfully realized. The resultant shielding materials displayed approximately 10% superior X-ray attenuation efficiency compared to that without polyphenol, and an averagely 9% increment in X-ray attenuation efficiency than that without hierarchical structure. Moreover, the obtained composite with a thickness of 2.8 mm displayed superior X-ray shielding performance compared to 0.25 mm lead sheet in 16–83 keV and retained an ultralow density of 1.4 g cm–3. Our research results would shed new light on the manufacture of high-performance X-ray shielding materials with excellent X-ray shielding performance.

Graphical Abstract
A novel mutation in the SOX5 gene c.1627del; p.(Tyr543IlefsTer14) is associated to Lamb–Shaffer syndrome: a case report
Authors: Cuenca Alcocel Jose , Criado Álamo Elena , Salvador-Rupérez Elvira , Goñi Ros Nuria , Izquierdo Álvarez Silvia , Peña Segura Jose Luis , González-Tarancón Ricardo 
Published: April 2023

Abstract
Background
Lamb–Shaffer syndrome (LAMSHF) is a rare neurodevelopmental disorder caused by heterozygous mutation or microdeletion involving the SOX5 gene. LAMSHF is characterize by developmental delay, intellectual disability, poor expressive speech, mild dysmorphic facial features and skeletal abnormalities.

Case presentation
We presented a case of a child with delayed psychomotor development in all areas, scoliosis, peculiar facies, and suspicion of intermittent endotropia, alteration in the alignment of one foot and difficulty in standing. These clinical features lead to genetics studies, in which a novel pathogenic variant in the SOX5 gene was detected in association with LAMSHF.

Conclusions
LAMSHF should be suspected in patients with developmental delay, speech delay, intellectual disability, behavioural disturbances, ophthalmological alterations and skeletal abnormalities. A novel pathogenic mutation in the SOX5 gene c.1627del p.(Tyr543IlefsTer14) was identified in this patient as responsible of Lamb–Shaffer syndrome. This case contributes to understanding the genetic characteristics, clinical features, and diagnosis of LAMSHF.
Prognostic value of right ventricular diastolic dysfunction in patients with inferior ST-elevated myocardial infarction
Authors: El Amrawy Ahmed Mahmoud , Zaghloul Shaimaa Abd ElKhalek , El Sharkawy Eman Mohamed , Sobhy Mohamed Ahmed 
Published: April 2023

Abstract
Background
Right ventricle infarction (RVI) is predominantly a complication of inferior wall myocardial infarction; it occurs in approximately one third of these patients. Right ventricular dysfunction in patients with inferior STEMI and RV infarction was under assessed. Nevertheless, studies which targeted RV assessment by echocardiography, did not routinely evaluate RV diastolic dysfunction. In this study, we aimed to evaluate RV diastolic dysfunction and its prognostic value in patients with inferior STEMI and RVI.

Results
Sixty patients with inferior STEMI and RV infarction, who underwent primary PCI were enrolled in the study. Patients with pre-existing clinical conditions that might affect RV function, were excluded. Echocardiography was performed within twenty-four hours following the PCI, to assess the RV systolic and diastolic functions with special focus on tricuspid inflow velocities (E velocity, A velocity and E/A ratio) by pulsed wave (PW) doppler and tricuspid annular velocities by tissue doppler index (TDI) (E′, A′ and E/E′ ratio). Clinical features and MACE, including cardiogenic shock, arrhythmia, stroke, reinfarction and death were analyzed in all our patients within 3 months follow up period. The average age of the study population was 51.58 ± 10.11 years, 10% were females. Five patients developed MACE (death, cardiogenic shock and pulmonary edema, anterior STEMI and cardiogenic shock, recurrent inferior STEMI, and arrhythmia and stroke), of whom four occurred in hospital within the first 48 h. Patients who developed MACE had high filling pressures, as all of them had E/E′ > 6. E′ velocity ≤ 6 cm/sec was associated with increased MACE as 25% of patients with E′ velocity ≤ 6 had MACE compared with 2.3% of patients with E′ velocity > 6 with a p value of 0.015.

Conclusions
Tricuspid annular velocities by TDI are essential when evaluating RV diastolic dysfunction. E/E′ and E′ velocity have a prognostic value in patients with inferior STEMI and RV infarction; E/E′ > 6 and E′ velocity ≤ 6 cm/sec were associated more MACE in patients with inferior STEMI and RVI.
Prevalence and characteristics of COVID-19 vaccine breakthrough infection in Upper Egypt
Authors: Hussein Aliae A. R. Mohamed , Hashem Maiada K. , Azizeldine Mohammed G. , Shaddad Ahmad M. 
Published: April 2023

Abstract
Background
Infection breakthrough after COVID-19 vaccination is a point of conflict in current literature not only because of the estimation of the potential hazards and symptoms severity but also due to establishing a vaccination policy and measuring the extent of immunity after vaccination in addition to the waning of the humoral immunity over time. To our knowledge, this is the first study to stratify the risk of post-COVID-19 vaccination breakthroughs in Upper Egypt.

Methods
In this cross-sectional observational study, we enrolled 369 vaccinated patients registered in our facility either admitted or in out-patient clinic. Patients were interviewed and any proven history of COVID-19 infection after vaccination was recorded.

Results
In the current study, 18.97% (70 patients) of the 369 subjects enrolled in the study had COVID-19breakthrough infection. Students were the high-risk group representing 18.6% of the study subjects. Hypertension, diabetes, and cardiac disease were the most comorbidities associated with a prevalence of 15.7%, 8.6%, and 4.3% respectively. Prior to COVID-19, confirmed infection was present in 42.9% of the study group. Fever, headache, myalgia, and cough were among the most common symptoms of the post-COVID vaccination breakthrough with a prevalence of 90%, 75.7%, 84.3%, and 74.3% respectively.

Conclusion
Breakthrough infection after COVID-19 vaccination is not uncommon. Most cases are mild and don’t require hospitalization. All types of vaccines tested in the current study offer adequate immunity and guard against severe COVID-19 infection. We encourage the current global policy of full vaccination.

Trial registration
ClinicalTrials.gov. NCT05033834. Registered September 5, 2021. COVID-19 Infection in After Vaccination-Full Text View-ClinicalTrials.gov.
Benefits of an Early Mobility Program for Hospitalized Patients With Cancer
Authors: Aronson Julia H. , Allen Olivia S. , Berkalieva Asem , Mazumdar Madhu , Gorbenko Ksenia , Gunning Melissa , Liu Mark , Kisswany Carol , Bhardwaj Aarti , Smith Cardinale B. 
Published: April 2023

PURPOSE Patients with cancer are often hospitalized with complications from cancer and cancer treatment. Many experience a decline in physical functioning, including loss of mobility, which likely contributes to increased length of stay (LOS) and increased readmissions. We aimed to determine whether a mobility program would improve quality of care and decrease health care utilization. METHODS We implemented a mobility aide program on an oncology unit in a large academic medical center for all patients without bedrest orders between October 1, 2018, and February 28, 2021. The program consisted of nursing evaluation using the Activity Measure for Post-Acute Care (AMPAC), an ordinal scale ranging from bed rest to ambulating ≥ 250 feet, to quantify mobility. Plan of care was determined in a multidisciplinary manner with physical therapy (PT), nursing, and a mobility aide, who is a medical assistant with enhanced rehabilitation training. Patients were then mobilized two times per day 7 days a week. Using descriptive statistics and mixed effects logistic regression, we evaluated the programs impact on LOS, readmissions, and changes in mobility during this time period compared with the 6-month interval before implementation. RESULTS A total of 1,496 hospitalized patients were identified. The odds of hospital readmission within 30 days of discharge was significantly less for those who received the intervention (OR, 0.53; 95% CI, 0.37 to 0.78; P = .001). The odds ratio (OR) of having a final AMPAC score at or above the median was significantly higher for those who received the intervention (OR, 1.60; 95% CI, 1.04 to 2.45; P < .05). There was no significant difference in LOS. CONCLUSION Use of this mobility program resulted in a significant decrease in readmissions and maintained or improved patients' mobility. This demonstrates that non-PT professionals can effectively mobilize hospitalized patients with cancer, thereby decreasing the burden on PT and nursing resources. Future work will evaluate the sustainability of the program and evaluate association with health care costs.
Associations of Slow-Wave Sleep With Prevalent and Incident Type 2 Diabetes in the Multi-Ethnic Study of Atherosclerosis
Authors: Kianersi Sina , Redline Susan , Mongraw-Chaffin Morgana , Huang Tianyi 
Published: April 2023

Abstract

Context
N3 sleep (i.e., slow-wave sleep), a marker of deep restorative sleep, is implicated in hormonal and blood pressure regulation and may impact cardiometabolic health.

Objective
We conducted cross-sectional and prospective analyses to test whether a higher proportion and longer duration of N3 sleep are associated with reduced type 2 diabetes risk.

Methods
A subsample of participants from the Multi-Ethnic Study of Atherosclerosis completed 1-night polysomnography at Exam 5 (2010-2013) and were prospectively followed until Exam 6 (2016-2018). We used modified Poisson regression to examine the cross-sectional associations of N3 proportion and duration with prevalent diabetes and Cox proportional hazards models to estimate risk of diabetes according to N3 measures.

Results
In cross-sectional analyses (n = 2026, mean age: 69 years), diabetes prevalence was 28% (n = 572). Compared with the first quartile (Q1) of the N3 proportion (&lt;2.0%), participants in Q4 (≥15.4%) were 29% (95% CI 0.58, 0.87) less likely to have prevalent diabetes (P trend = .0016). The association attenuated after adjustment for demographics, lifestyles, and sleep-related factors (P trend = .3322). In prospective analyses of 1251 participants and 129 incident cases over 6346 person-years of follow-up, a curvilinear relationship was observed between N3 proportion and incident diabetes risk. In the fully adjusted model, the hazard ratio (95% CI) of developing diabetes vs Q1 was 0.47 (0.26, 0.87) for Q2, 0.34 (0.15, 0.77) for Q3, and 0.32 (0.10, 0.97) for Q4 (P nonlinearity = .0213). The results were similar for N3 duration.

Conclusion
Higher N3 proportion and longer N3 duration were prospectively associated with lower type 2 diabetes risk in a nonlinear fashion among older American adults.
A Multiomics Atlas of Brown Adipose Tissue Development Over Time
Authors: Kumagai Yutaro , Saito Yutaka , Kida Yasuyuki S 
Published: April 2023

Abstract
Brown adipose tissue (BAT) regulates homeostatic energy balances in response to physiological changes such as nutrition intake, calorie restriction, exercise, and environmental temperature by consuming energy to generate heat, and thus serves as an important organ for obesity and metabolic diseases. We performed an integrated transcriptomic and metabolomic characterization of developing mouse BAT from embryo to adult to obtain a time-resolved picture of BAT development. We demonstrated that there are 2 distinct developmental changes that are BAT specific. We also examined transcription factor binding sites and discovered key transcription factors in the developmental time course. A comparison of our data with other organ development transcriptome and metabolome data revealed BAT-specific transcriptome and metabolome patterns. Our findings provide an overview of mouse BAT development as well as implications for developmental and functional BAT controls.
Colon Cancer Presenting as Pituitary Mass and Hypopituitarism: Recognition and Multidisciplinary Approach of a Rare Case
Authors: Costanza Flavia , Giampietro Antonella , Mattogno Pier Paolo , Chiloiro Sabrina 
Published: April 2023

Abstract
Pituitary metastases are rare. Until now, few cases have been reported; about 50% of pituitary metastases originate from breast or lung cancers. We describe the clinical case of a primary colon carcinoma first presenting with a pituitary metastasis. A 76-year-old woman, with no history of malignancy, presented with headache, dizziness, and diplopia, at the Emergency Department. The neurologic examination was remarkable for complete left ophthalmoplegia with sensitivity deficit on the left side of the face. Radiologic investigations documented a voluminous sellar and suprasellar lesion, with extension in the left cavernous sinus and temporal lobe. Pituitary hormone levels were suggestive of anterior hypopituitarism and mild hyperprolactinemia. Subtotal surgical removal of the lesion was achieved through a trans-sphenoidal endoscopic endonasal approach. The histological examination disclosed a metastasis of gastrointestinal adenocarcinoma. A subsequent colonoscopy identified right colon cancer. A contrasted total-body computerized tomography ruled out other metastases. Postsurgical MRI showed a stable parasellar residual tumor. Conventional radiotherapy was scheduled.
This case underlines the importance of considering pituitary metastases in the differential diagnosis of aggressive pituitary lesions, which should be managed in a pituitary tumor center of excellence through a multidisciplinary approach, for the complexity in diagnosis and therapeutic management of this rare condition.
Atypical Course of a Patient With AIP-Positive Acromegaly: From GH Excess to GH Deficiency and Back to GH Excess
Authors: García-de-la-Torre Keren-Sandyn , Kerbel Jacobo , Cano-Zaragoza Amayrani , Mercado Moisés 
Published: April 2023

Abstract
Acromegaly/giantism results from the chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1), in more than 96% of cases, due to a GH-secreting pituitary adenoma. Primary treatment of choice is transsphenoidal resection of the adenoma. More than 30% to 40% of operated cases require adjunctive forms of treatment, be it pharmacological or radiotherapeutical. The multimodal treatment of acromegaly has resulted in substantial improvements in the quality of life and life expectancy of these patients. We herein present the complex case of a patient with acromegaly due to a mammosomatotrope adenoma, with a germ-line AIP (aryl hydrocarbon receptor–interacting protein) mutation, who had a chronic and protracted course of more than 15 years during which he was treated with surgery, somatostatin receptor ligands, dopamine agonist, and the GH receptor antagonist pegvisomant. At one point, he was able to come off medications and was even found to be transiently GH-deficient, only to develop acromegaly again after a couple of years.
Cattle, Viral Invasions, and State-Society Relations in a Colonial Korean Borderland
Authors: Seeley Joseph 
Published: April 2023

Abstract
For early twentieth-century Koreans, one of the most feared invaders to breach the country’s northern border with China was the tiny viral pathogen Rinderpest morbillivirus (rinderpest, or cattle plague). This study examines the social consequences of rinderpest outbreaks along the colonial Sino-Korean border and the methods undertaken by the Japanese Government-General of Korea to control viral “invasions” from Manchuria. Rinderpest prevention primarily functioned as an extension of the colonial police. Despite universal fears of rinderpest’s ravages, which devastated a rural economy dependent on animal labor, colonized Koreans exhibited wide-ranging reactions to the heavy-handed methods adopted by imperial officials to fight the disease. Korean responses included outright resistance such as cross-border cattle smuggling, attacking veterinary officials, or protests against livestock travel bans, as well as varying degrees of cooperation. Moving chronologically from before the beginning of formal colonial rule in 1910 until the 1930s, this article strives to explain how a modern veterinary regime was implemented and negotiated in the northern colonial Korean borderland. Such a view is essential for understanding not only Korea’s colonial past but also Korean responses to infectious disease “invasions” in the present day.
Romanticism Strait: Coloniality and Liminality in Im Hwa’s Maritime Poetry
Authors: Smith Kevin Michael 
Published: April 2023

AbstractThis article examines the colonial-era poet and critic Im Hwa’s (林和 1908–1953) maritime literary trope of Hyŏnhaet’an (玄海灘), the strait separating the Korean peninsula from the Japanese archipelago, as it encompasses Korea’s contradictory peripheral location within the Japanese empire. Im Hwa’s repeated invocations of this body of water served as a channel for navigating the escalating pressures of colonial censorship, in which the romanticized, masculinist figure of the valiant “youth” (ch’ŏngnyŏn) substituted for the former working-class protagonist from Im’s esteemed “short narrative poems” (tanp’yŏn sŏsasi) during the heyday of the proletarian literary movement. Further, Im’s fixation on the vicissitudes of the seafaring journey across the strait can be said to articulate the precarious position occupied by Korean colonial subjects of the Japanese emperor, neither permitted full assimilation nor capable of enduring perpetual subjugation as second-class citizens. The article concludes by exploring how the liminality of passage across Hyŏnhaet’an exemplifies both the tensions between nationalism and social class in the revised geopolitical contours of Im’s anti-colonial, oceanic imagination, what he eloquently referred to as a “new map of the peninsula” (pando ŭi sae chido).
Black and Queer, Music on Screen
Authors: Tobias James 
Published: April 2023

AbstractWhile Black Studies and Queer Studies have offered a range of terms and methods for considering sound, music, and musicality in audiovisual work over the last half century, studies of sound and music in audiovisual media that have attempted to define these latter disciplines have tended to neglect or simply ignore those innovations. The result is a lack of attention and analysis given to key forces and voices at important moments of media transition. This editor's introduction surveys relevant methods and exemplars to demonstrate this problem of disciplinary blind spots and suggests ways that contributions to this special issue help to address and reorient it.