bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling of particulate contamination redistribution inside purged cavities
Authors: Faye D , Dall’armi F , Bombardier P 
Published: August 2023

Abstract
Sophisticated instruments on-board most of satellite payloads, especially scientific ones, are sensitive to particulate contamination since their performance can be affected in terms of straylight or surface obscuration. The surface cleanliness levels have to be minimized on ground. However, even if the deposition rate is controlled in cleanroom, the hardware is continuously exposed to particles and fibers, moving in the airflow and settling according to their various sizes and matter compositions. Thus, depending on the initial surface cleanliness level, the redistribution of particulate contamination can be a concern during integration and tests activities until launch, when venting and/or vibrations occur which results in more or less random fallout of particles. Previous studies identified different steps for the transfer mechanism such as detachment, transport and interaction with the surface (with or without bounce). Therefore, it is paramount to understand the physical phenomena of particle resuspension that happens either inside purged cavities of spacecraft or under fairing in order to be able to model them as for molecular contamination. After performing a state of the art of the existing detachment models, a Computational Fluid Dynamics software, scSTREAM, has been chosen among the most relevant ones for a feasibility study to simulate particles redistribution. This tool was particularly interesting due to the possibility to add specific functions for computation. For the purpose, the Rock’n’Roll (R’n’R) model has been implemented to consider particle resuspension. In parallel, some simple test configurations have been defined and a mock-up with several adjacent cavities has been used to compare theory and experiment when a purging under dry nitrogen was applied in the vicinity of a pre-contaminated surface. The relocation of FluoDust particles, as the source of contamination, deposited on a specific substrate has been evaluated thanks to many collector plates disseminated in one or two cavities and the levels quantified. The impact of different test conditions (flow rate, material of the substrate, presence of leakage, initial contamination level…) has been investigated. This paper presents the comparative results that confirmed the redistribution of the particulate contamination with similar trajectories but also some discrepancies due to the limitations of the R’n’R model and depending on experimental parameters such as initial distribution of particles, adherence force to the substrate…
Regolith adherence characterization (RAC) experiment on the Moon and it’s ground-based simulation: Materials Issues
Authors: Kleiman Jacob , Iskanderova Zelina , Krishtein Leon , Ng Richard , Sodhi Rana 
Published: August 2023

Abstract
The interaction of Lunar dust and other environmental factors, like vacuum, temperatures, solar radiation, ultraviolet irradiation, and electron (e-) and proton (p+) irradiation with structures on the Moon and the outside of the future Gateway Lunar station may lead to permanent change or complete loss of thermal, optical, and other functionalities that could potentially lead to catastrophic failures. Among these factors, Lunar regolith dust is the most aggressive, causing the main problems.
ITL recently initiated a program to evaluate, further develop, and enhance its unique cornerstone Lunar Dust Mitigation Technology (DMT) for sensitive materials on external space structures. In the framework of this program, ITL prepared a set of DMT-treated samples for inclusion in the “Regolith Adherence Characterization (RAC) Payload” funded by NASA and developed and built by Aegis.
Regolith Adherence Characterization (RAC) Payload mission will determine how lunar regolith dust sticks to a range of space materials and coatings (collected from NASA, academia, and industry) exposed to the Moon’s environment at different phases of flight caused by 1) landing, and 2) during routine lander operations.
To understand the results of the Lunar exposure experiment, an extensive program was initiated at ITL where a set of experiments on interaction of Lunar dust simulants with samples, similar to the RAC Payload experiments on the Moon, will be conducted in ITL’s Vacuum Lunar Dusty Environment Simulator that will be upgraded for this project.
This paper will discuss mainly the material problems and their preparation for experiments. The detailed description of the Vacuum Lunar Dusty Environment Simulator and the results obtained in it will be published elsewhere in upcoming publications.
New horizons in cognitive and functional impairment as a consequence of cerebral small vessel disease
Authors: Tap Lisanne , Vernooij Meike W , Wolters Frank , van den Berg Esther , Mattace-Raso Francesco U S 
Published: August 2023

Abstract
Cerebral small vessel disease (cSVD) is a frequent finding in imaging of the brain in older adults, especially in the concomitance of cardiovascular disease risk factors. Despite the well-established link between cSVD and (vascular) cognitive impairment (VCI), it remains uncertain how and when these vascular alterations lead to cognitive decline. The extent of acknowledged markers of cSVD is at best modestly associated with the severity of clinical symptoms, but technological advances increasingly allow to identify and quantify the extent and perhaps also the functional impact of cSVD more accurately. This will facilitate a more accurate diagnosis of VCI, against the backdrop of concomitant other neurodegenerative pathology, and help to identify persons with the greatest risk of cognitive and functional deterioration. In this study, we discuss how better assessment of cSVD using refined neuropsychological and comprehensive geriatric assessment as well as modern image analysis techniques may improve diagnosis and possibly the prognosis of VCI. Finally, we discuss new avenues in the treatment of cSVD and outline how these contemporary insights into cSVD can contribute to optimise screening and treatment strategies in older adults with cognitive impairment and multimorbidity.
How (and How Not) to Study Porn
Authors: Lubey Kathleen 
Published: August 2023

Abstract
Over the past several decades, porn studies has cohered as an interdisciplinary field built by scholars of feminism, race, media studies, history, literature, sociology, gender studies, and queer theory. The most compelling recent work in the field, like Heather Berg’s Porn Work (2021) and Steven Ruszczycky’s Vulgar Genres (2021), approaches pornography as a broad textual and cultural field rich with information about how we imagine, consume, and construct sex. They show that the category of pornography expands and deepens as texts are written, excerpted, and republished; as sex workers invent new outlets and conditions for their labor; and as new technologies increase access for user interaction. Such work shows us not simply how pornography indexes pleasure, but how it creates politics, community, and labor theory. Some scholarship, meanwhile, remains wearily sedimented in polarizing arguments for or against pornography’s value, like Bernadette Barton’s The Pornification of America (2021). Locked into an assumption that pornography is harmful and irredeemable, such work avoids engaging with pornographic texts themselves and ignores recent work in the very field to which it claims to make urgent contributions.[T]he best work [in porn studies] defines pornography not as identifiable texts, videos, or films, but as a field that connects sex to the myriad social relations that shape it: gender, labor, pop culture, and consumption.
Diagnostic Logic and Forensic Reading: The Case ofWieland
Authors: Grubbs Lindsey 
Published: August 2023

AbstractAt the end of the eighteenth century, professional and lay audiences alike negotiated the lines between mental health and disorder, questioning whether criminal behavior, for example, laid within medicine’s jurisdiction. This essay examines the role of literature in developing a “diagnostic logic” that trained readers in evolving forms of mental surveillance. First, it shows how physicians like Benjamin Rush relied on popular and literary sources to create new diagnostic categories, citing newspaper crime reports and Shakespearean plays as medical evidence and encouraging readers to interpret familiar behavior through the lens of pathology. Next, I turn to Charles Brockden Brown’s Wieland (1798) to demonstrate how the novel’s suspicion of empiricism could paradoxically heighten readers’ desire to sort and predict behavior. Soliciting readers’ interest through scenes of gothic horror, the novel concludes by urging readers to apply their diagnostic skills in more mundane social settings. Moreover, unlike Rush’s straightforward assessment of pathology’s mitigating impact on accountability, Brown’s novel invites readers to reach their own conclusions on the ethical implications of diagnosis. Ultimately, I argue, texts like Wieland did not simply work alongside medical tracts to authorize the surveillance of an increasing number of pathologized behaviors, but deepened readers’ engagement in doing so.
Madness, and What Passes for Civilization: The Way We Diagnose Now
Authors: Sadowsky Jonathan 
Published: August 2023

Abstract
Two new books, one by a journalist and one by a historian, reveal enduring and novel paradoxes of mental illness and its treatment. The mentally ill are, perhaps by definition, people whose perception of reality departs from the consensual. Yet they often have uncanny insights that elude the healthy. Sometimes the mentally ill value aspects of their illness experience but also welcome the relief from symptoms that treatments can bring. The advent of psychopharmacology may have led to an over-reliance on drugs for some populations, while, at the same time, leaving people with less access to health care under-medicated. Mental illness is sometimes imagined as an affliction of the affluent, yet decades of social research has shown that it is more likely to impair the poor. Substantial evidence suggests reducing poverty would also reduce the incidence of many mental illnesses, yet this step is rarely a part of the relevant policy discussions.
[Aviv suggests] that stories of mental illness follow a standard plot. . . . with an idyllic setting. . . . broken by the intrusion of illness. . . . [but] the poor are most likely to experience mental illnesses. . . . studies. . . . [show] that less poverty would mean less mental illness. . . . Yet little was ever done.
Polypharma Fiction
Authors: Blum Beth 
Published: August 2023

AbstractThis article examines how the rise of polypharmacy changes the novel genre’s response to the pain of anxiety and its narrative interest. Necessarily focusing its scope while also registering the fluidity, complexity, and exigency of contemporary psychopharmacological experience, it focuses specifically on how anti-anxiety and anti-depressant medications are activating an ongoing reassessment among contemporary novelists of ingrained assumptions regarding the centrality of mental suffering to aesthetics. The books I discuss as “polypharma fictions”—by Sheila Heti, Ottessa Moshfegh, and Anelise Chen—each challenge the idea of psychic pain as a precondition of narrative development—whether the pain of existential anxiety (Heti), capitalist aspiration (Moshfegh), or willful determination (Chen). Moving beyond the extremes of alarmism and advocacy that have largely structured scholarly responses to the rise of psychotropics, I attend to the formal significance of psychotropics for narrative temporality, tension, and plot.In this more recent fiction, the question is not whether psychotropics presage the end of the novel genre but, rather, what kind of novel it is that incorporates psychopharmaceuticals and, yet . . . goes on.
Association of perioperative allogeneic blood transfusions and long-term outcomes following radical surgery for gastric and colorectal cancers: systematic review and meta-analysis of propensity-adjusted observational studies
Authors: Zhang Weilan , Xu Huimian , Huang Baojun , Xu Yan , Huang Jinyu 
Published: August 2023

Abstract

Background
Previous meta-analyses reporting significant associations between perioperative allogeneic blood transfusions and poor prognosis in gastric cancer or colorectal cancer had a high risk of confounding bias. This meta-analysis explored this issue using observational studies that applied propensity score analysis.

Methods
PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched for manuscripts published between 2013 and 2022. Studies applying propensity score analysis were included to investigate the association between perioperative allogeneic blood transfusions and prognosis in gastric cancer or colorectal cancer after radical surgery. Pooled HRs for overall survival and disease-free survival were calculated using a fixed-effect model or random-effect model according to heterogeneity.

Results
Twelve retrospective cohort studies with 17 607 patients reported were included. Ten studies applied propensity score matching and two applied inverse probability of treatment weighting using propensity score. A total of 5962 patients were analysed after propensity score adjustment. After propensity score adjustment, perioperative allogeneic blood transfusions did not correlate with disease-free survival in gastric cancer (HR 1.16; 95 per cent c.i. 0.96–1.39; heterogeneity was assessed by the chi-squared test and inconsistency index (I2) = 57 per cent) or colorectal cancer (HR 1.12; 95 per cent c.i. 0.84–1.49; I2 = 54 per cent). However, after propensity score adjustment, perioperative allogeneic blood transfusions were significantly associated with worse overall survival in gastric cancer (HR 1.20; 95 per cent c.i. 1.08–1.32; I2 = 25 per cent) and colorectal cancer (HR 1.40; 95 per cent c.i. 1.06–1.85; I2 = 52 per cent). Subgroup analyses showed that perioperative allogeneic blood transfusions did not correlate with overall survival in colorectal cancer when major postoperative complications were balanced after propensity score.

Conclusion
Perioperative allogeneic blood transfusion is not correlated with recurrence of gastric cancer and colorectal cancer. Perioperative allogeneic blood transfusions are significantly associated with worse overall survival in gastric cancer and colorectal cancer, which may be attributable to unbalanced major postoperative complications after propensity score adjustment.
On the road to colorectal cancer development: crosstalk between the gut microbiota, metabolic reprogramming, and epigenetic modifications
Authors: Chen Anqi , Jiang Zhengting , Cai Lingli , Tang Dong 
Published: August 2023

Abstract
An increasing number of studies have reported the role of gut microbes in colorectal cancer (CRC) development, as they can be influenced by dietary metabolism and mediate alterations in host epigenetics, ultimately affecting CRC. Intake of specific dietary components can affect gut microbial composition and function, and their metabolism regulates important epigenetic functions that may influence CRC risk. Gut microbes can regulate epigenetic modifications through nutrient metabolism, including histone modification, DNA methylation, and noncoding RNAs. Epigenetics, in turn, determines the gut microbial composition and thus influences the risk of developing CRC. This review discusses the complex crosstalk between metabolic reprogramming, gut microbiota, and epigenetics in CRC and highlights the potential applications of the gut microbiota as a biomarker for the prevention, diagnosis, and therapy of CRC.
Longitudinal developmental trajectories of functional connectivity reveal regional distribution of distinct age effects in infancy
Authors: Liu Janelle , Chen Haitao , Cornea Emil , Gilmore John H , Gao Wei 
Published: August 2023

AbstractPrior work has shown that different functional brain networks exhibit different maturation rates, but little is known about whether and how different brain areas may differ in the exact shape of longitudinal functional connectivity growth trajectories during infancy. We used resting-state functional magnetic resonance imaging (fMRI) during natural sleep to characterize developmental trajectories of different regions using a longitudinal cohort of infants at 3 weeks (neonate), 1 year, and 2 years of age (n = 90; all with usable data at three time points). A novel whole brain heatmap analysis was performed with four mixed-effect models to determine the best fit of age-related changes for each functional connection: (i) growth effects: positive-linear-age, (ii) emergent effects: positive-log-age, (iii) pruning effects: negative-quadratic-age, and (iv) transient effects: positive-quadratic-age. Our results revealed that emergent (logarithmic) effects dominated developmental trajectory patterns, but significant pruning and transient effects were also observed, particularly in connections centered on inferior frontal and anterior cingulate areas that support social learning and conflict monitoring. Overall, unique global distribution patterns were observed for each growth model indicating that developmental trajectories for different connections are heterogeneous. All models showed significant effects concentrated in association areas, highlighting the dominance of higher-order social/cognitive development during the first 2 years of life.
Ablation of AQP5 gene in mice leads to olfactory dysfunction caused by hyposecretion of Bowman’s gland
Authors: Zhao Xinnan , Liu Gang , Yu Xin , Yang Xiaohan , Gao Wenting , Zhao Zinan , Ma Tonghui , Ma Jianmei 
Published: August 2023

Abstract
Smell detection depends on nasal airflow, which can make absorption of odors to the olfactory epithelium by diffusion through the mucus layer. The odors then act on the chemo-sensitive epithelium of olfactory sensory neurons (OSNs). Therefore, any pathological changes in the olfactory area, for instance, dry nose caused by Sjögren’s Syndrome (SS) may interfere with olfactory function. SS is an autoimmune disease in which aquaporin (AQP) 5 autoantibodies have been detected in the serum. However, the expression of AQP5 in olfactory mucosa and its function in olfaction is still unknown. Based on the study of the expression characteristics of AQP5 protein in the nasal mucosa, the olfaction dysfunction in AQP5 knockout (KO) mice was found by olfactory behavior analysis, which was accompanied by reduced secretion volume of Bowman’s gland by using in vitro secretion measure system, and the change of acid mucin in nasal mucus layer was identified. By excluding the possibility that olfactory disturbance was caused by changes in OSNs, the result indicated that AQP5 contributes to olfactory functions by regulating the volume and composition of OE mucus layer, which is the medium for the dissolution of odor molecules. Our results indicate that AQP5 can affect the olfactory functions by regulating the water supply of BGs and the mucus layer upper the OE that can explain the olfactory loss in the patients of SS, and AQP5 KO mice might be used as an ideal model to study the olfactory dysfunction.
A quick test to objectify smell and taste dysfunction at home: a proof of concept for the validation of the chemosensory perception test
Authors: Levesque-Boissonneault Cindy , Bussière Nicholas , Roy-Côté Frédérique , Cloutier Frank , Caty Marie-Ève , Frasnelli Johannes 
Published: August 2023

Abstract
Recent studies have shown the efficacy of a home test for the self-evaluation of olfactory and gustatory functions in quarantined coronavirus disease-2019 (COVID-19) patients. However, testing was often limited to COVID-19 participants, and the accuracy of home test kits was rarely compared to standardized testing. This study aims at providing proof of concept for the validation of the new Chemosensory Perception Test (CPT) developed to remotely assess orthonasal olfactory, retronasal olfactory, and gustatory functions in various populations using common North American household items. In the 2 experiments, a total of 121 participants irrespective of having olfactory and/or gustatory complaints from various causes (COVID-19, sinunasal, post-viral, idiopathic) were tested first, with one or many of the following tests: (i) a brief chemosensory questionnaire, (ii) an olfactory test—Sniffin’ Sticks Test (SST) or University of Pennsylvania Smell Identification Test (UPSIT), and/or (iii) a gustatory test—Brief Waterless Empirical Taste Test (B-WETT). We then applied the CPT which yielded 3 different subscores, namely orthonasal, retronasal, and gustatory CPT scores. The orthonasal CPT score was significantly correlated with SST (ρ = 0.837, P &lt; 0.001) and UPSIT (ρ = 0.364, P &lt; 0.001) scores, and exhibited an excellent accuracy to identify olfactory dysfunction (OD) as compared to SST (area under the curve [AUC]: 0.923 [95% confidence interval {CI}, 0.822–1.000], P &lt; 0.001). The retronasal CPT score but not the gustatory CPT score allowed to distinguish between participants with or without subjective gustatory complaint (AUC: 0.818 [95% CI, 0.726–0.909], P &lt; 0.001). The CPT has the ability to identify OD and to quantify subjective gustatory complaints.
Relationships Between Schistosoma mansoni Infection Intensity and Nutritional Status and Anemia Among Preschool-aged Children in Uganda
Authors: Colt Susannah , Miller Cole D , Edielu Andrew , Webb Emily L , Mawa Patrice A , Wu Hannah W , Nakyesige Racheal , Muheki Edridah , Kabatereine Narcis , Bustinduy Amaya L , Friedman Jennifer F 
Published: August 2023

Abstract
In a cross-sectional analysis of 354 Ugandan children (age 12–48 months) infected with Schistosoma mansoni, we assessed relationships between infection intensity and nutritional morbidities. Higher intensity was associated with an increased risk for anemia (RR = 1.05, 95% confidence interval [CI] 1.01–1.10) yet not associated with risk for underweight, stunting, or wasting.
Identifying Effective Durations of Antibiotic Therapy for the Treatment of Carbapenem-resistant Enterobacterales Bloodstream Infections: A Multicenter Observational Study
Authors: Soto Caitlin L , Hsu Alice J , Lee Jae Hyoung , Dzintars Kathryn , Choudhury Rebecca , Jenkins Timothy C , McCreary Erin K , Quartuccio Katelyn S , Stohs Erica J , Zimmerman Matty , Tamma Pranita D 
Published: August 2023

Abstract
In a propensity-score-weighted cohort of 183 adults with carbapenem-resistant Enterobacterales bacteremia at 24 US hospitals, patients receiving short courses of active therapy (7–10 days, median 9 days) experienced similar odds of recurrent bacteremia or death within 30 days as those receiving prolonged courses of active therapy (14–21 days, median 14 days).