bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Imprinted Immunity Induced by mRNA Vaccination in an Experimental Animal Model
Authors: Fujita Shigeru , Uriu Keiya , Pan Lin , Nao Naganori , Tabata Koshiro , Kishimoto Mai , Itakura Yukari , Sawa Hirofumi , Kida Izumi , Tamura Tomokazu ,   The Genotype to Phenotype Japan (G2P-Japan) Consortium, Kaku Yu , Misawa Naoko , Plianchaisuk Arnon , Guo Ziyi , Hinay Alfredo A , Tolentino Jarel Elgin M , Chen Luo , Suganami Mai , Chiba Mika , Yoshimura Ryo , Yasuda Kyoko , Iida Keiko , Ohsumi Naomi , Strange Adam P , Tanaka Shiho , Suzuki Rigel , Suzuki Saori , Ito Hayato , Tanaka Shinya , Tsuda Masumi , Wang Lei , Oda Yoshikata , Ferdous Zannatul , Shishido Kenji , Sadamasu Kenji , Yoshimura Kazuhisa , Asakura Hiroyuki , Yoshida Isao , Nagashima Mami , Nakagawa So , Shirakawa Kotaro , Takaori-Kondo Akifumi , Nagata Kayoko , Nomura Ryosuke , Horisawa Yoshihito , Tashiro Yusuke , Kawai Yugo , Takayama Kazuo , Hashimoto Rina , Deguchi Sayaka , Watanabe Yukio , Sakamoto Ayaka , Yasuhara Naoko , Hashiguchi Takao , Suzuki Tateki , Kimura Kanako , Sasaki Jiei , Nakajima Yukari , Yajima Hisano , Irie Takashi , Kawabata Ryoko , Tabata Kaori , Ikeda Terumasa , Nasser Hesham , Shimizu Ryo , Begum MST Monira , Jonathan Michael , Mugita Yuka , Takahashi Otowa , Ichihara Kimiko , Ueno Takamasa , Motozono Chihiro , Toyoda Mako , Saito Akatsuki , Shofa Maya , Shibatani Yuki , Nishiuchi Tomoko , Fukuhara Takasuke , Ito Jumpei , Matsuno Keita , Sato Kei 
Published: June 2023

Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants has led to concerns that ancestral SARS-CoV-2-based vaccines may not be effective against newly emerging Omicron subvariants. The concept of “imprinted immunity” suggests that individuals vaccinated with ancestral virus-based vaccines may not develop effective immunity against newly emerging Omicron subvariants, such as BQ.1.1 and XBB.1. In this study, we investigated this possibility using hamsters. Although natural infection induced effective antiviral immunity, breakthrough infections in hamsters with BQ.1.1 and XBB.1 Omicron subvariants after receiving the 3-dose mRNA-lipid nanoparticle vaccine resulted in only faintly induced humoral immunity, supporting the possibility of imprinted immunity.
Boosting line intensity map signal-to-noise ratio with the Ly-α forest cross-correlation
Authors: Qezlou Mahdi , Bird Simeon , Lidz Adam , Sun Guochao , Newman Andrew B , Rudie Gwen C , Ni Yueying , Croft Rupert , Di Matteo Tiziana 
Published: June 2023

ABSTRACT
We forecast the prospects for cross-correlating future line intensity mapping (LIM) surveys with the current and future Ly-α forest measurements. Using large cosmological hydrodynamic simulations, we model the emission from the CO rotational transition in the CO Mapping Array Project LIM experiment at the 5-yr benchmark and the Ly-α forest absorption signal for extended Baryon Acoustic Oscillations (BOSS), Dark energy survey instrument (DESI), and Prime Focus multiplex Spectroscopy survey (PFS). We show that CO × Ly-α forest significantly enhances the detection signal-to-noise ratio (S/N) of CO, with up to $300{{\ \rm per\, cent}}$ improvement when correlated with the PFS Ly-α forest survey and a 50–75 per cent enhancement with the available eBOSS or the upcoming DESI observations. This is competitive with even CO × spectroscopic galaxy surveys. Furthermore, our study suggests that the clustering of CO emission is tightly constrained by CO × Ly-α forest due to the increased sensitivity and the simplicity of Ly-α absorption modelling. Foreground contamination or systematics are expected not to be shared between LIM and Ly-α forest observations, providing an unbiased inference. Ly-α forest will aid in detecting the first LIM signals. We also estimate that [C ii] × Ly-α forest measurements from Experiment for Cryogenic Large-Aperture Intensity Mapping and DESI/eBOSS should have a larger S/N than planned [C ii] × quasar observations by about an order of magnitude.
Hyperbolic limit on the early arrival time of bright pulses from PSR J0835−4510 (Vela)
Authors: Mahida Angiraben D , Palfreyman J L , Molera Calvés G , Sett Susmita 
Published: June 2023

ABSTRACT
Astronomers have studied the Vela pulsar (PSR J0835−4510) for decades. This study analyses almost 100 h of single-pulse data collected over three consecutive days in 2016 and 2020. The work investigates the fascinating phenomena of the earlier arrival of brighter pulses with their increase in peak intensity. We found a hyperbolic relation between them by constructing integrated pulse profiles using flux density intervals and examining the relationship between pulse arrival time and intensity. We identified a phase limit of −0.85 ± 0.0109 ms for the earliest arrival of the brightest pulses. This study offers exciting prospects for further exploring the emission regions responsible for the Vela pulsar’s regular pulses and giant micro-pulses.
Cocoon cooling emission in neutron star mergers
Authors: Hamidani Hamid , Ioka Kunihito 
Published: June 2023

ABSTRACT
In the gravitational wave event GW170817, there was a ∼10 h gap before electromagnetic (EM) observations, without detection of the cocoon. The cocoon is heated by a short gamma-ray burst (sGRB) jet propagating through the ejecta of a neutron star (NS) merger, and a part of the cocoon escapes the ejecta with an opening angle of 20°–30°. Here, we model the cocoon and calculate its EM emission. Our 2D hydrodynamic simulations suggest that the density and energy distributions, after entering homologous expansion, are well-fitted with power-law functions, in each of the relativistic and non-relativistic parts of the escaped cocoon. Modelling these features, we calculate the cooling emission analytically. We find that the cocoon outshines the r-process kilonova/macronova at early times (10–103 s), peaking at UV bands. The relativistic velocity of the cocoon’s photosphere is measurable with instruments such as Swift, ULTRASAT, and LSST. We also imply that energetic cocoons, including failed jets, might be detected as X-ray flashes. Our model clarifies the physics and parameter dependence, covering a wide variety of central engines and ejecta of NS mergers and sGRBs in the multimessenger era.
Should Nicotine Replacement Therapy be Provided Free of Charge? A Cost-Utility Analysis in Sweden
Authors: Gebreslassie Mihretab , Galanti Maria Rosaria , Feldman Inna , Lager Anton 
Published: June 2023

AbstractIntroductionTreatment with nicotine replacement therapy (NRT) during an attempt to quit smoking increases the likelihood of success by about 55%. However, out-of-pocket payment for NRT can hinder its use.Aims and MethodsThis study aims therefore to assess the cost-effectiveness of subsidizing NRT in Sweden. A homogeneous cohort-based Markov model was used to assess the lifetime costs and effects of subsidized NRT from a payer and societal perspective. Data to populate the model were retrieved from the literature, and selected parameters were varied in deterministic and probabilistic sensitivity analyses to assess robustness of model outputs. Costs are presented in USD, year 2021.ResultsA 12-week treatment with NRT was estimated to cost USD 632 (474–790) per person. From a societal perspective, subsidized NRT was a cost-saving alternative in 98.5% of the simulations. NRT is cost-saving across all ages, but the health and economic gains are somewhat larger among younger smokers from a societal perspective. When a payer perspective was used, the incremental cost-effectiveness ratio was estimated at 14 480 (11 721–18 515) USD per QALY which was cost-effective at a willingness to pay of 50 000 USD per QALY in 100 % of the simulations. Results were robust with realistic changes in the inputs during scenario and sensitivity analyses.ConclusionsSubsidizing NRT is potentially a cost-saving smoking cessation strategy from a societal perspective and cost-effective from a payer perspective.ImplicationsThis study found that subsidizing NRT is potentially a cost-saving smoking cessation policy alternative compared to current practice from a societal perspective. From a healthcare payer perspective, subsidizing NRT is estimated to cost USD 14 480 to gain an extra QALY. NRT is cost-saving across all ages, but the health and economic gains are somewhat larger among younger smokers from a societal perspective. Moreover, subsidizing NRT removes the financial barriers that are mostly faced by socioeconomically disadvantaged smokers which might reduce health inequalities. Thus, future economic evaluations should further investigate the health inequality impacts with methods that are more suitable for this.
Temperature, phosphorus and species composition will all influence phytoplankton production and content of polyunsaturated fatty acids
Authors: Calderini Marco L , Pääkkönen Salli , Salmi Pauliina , Peltomaa Elina , Taipale Sami J 
Published: June 2023

Abstract
Temperature increases driven by climate change are expected to decrease the availability of polyunsaturated fatty acids in lakes worldwide. Nevertheless, a comprehensive understanding of the joint effects of lake trophic status, nutrient dynamics and warming on the availability of these biomolecules is lacking. Here, we conducted a laboratory experiment to study how warming (18–23°C) interacts with phosphorus (0.65–2.58 μM) to affect phytoplankton growth and their production of polyunsaturated fatty acids. We included 10 species belonging to the groups diatoms, golden algae, cyanobacteria, green algae, cryptophytes and dinoflagellates. Our results show that both temperature and phosphorus will boost phytoplankton growth, especially stimulating certain cyanobacteria species (Microcystis sp.). Temperature and phosphorus had opposing effects on polyunsaturated fatty acid proportion, but responses are largely dependent on species. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) synthesizing species did not clearly support the idea that warming decreases the production or content of these essential polyunsaturated fatty acids. Our results suggest that warming may have different effects on the polyunsaturated fatty acid availability in lakes with different nutrient levels, and that different species within the same phytoplankton group can have contrasting responses to warming. Therefore, we conclude that future production of EPA and DHA is mainly determined by species composition.
Gastroesophageal reflux disease
Authors: Smith Whitney , Davila Natalia 
Published: June 2023

Abstract:
In 2021, the American College of Gastroenterology updated its diagnosis and treatment guideline for gastroesophageal reflux disease (GERD). This article provides a summary of noteworthy changes to the guideline and describes clinical pearls that are pertinent to the diagnosis and treatment of GERD in primary care.
Comparative analysis of real-world data of frequent treatment sequences in metastatic prostate cancer
Authors: Jaipuria Jiten , Kaur Ishleen , Doja Mohammad Najmud , Ahmad Tanvir , Singh Amitabh , Rawal Sudhir Kumar , Talwar Vineet , Sharma Girish 
Published: June 2023

Abstract

Background
The incidence of prostate cancer is increasing worldwide. A significant proportion of patients develop metastatic disease and are initially prescribed androgen deprivation therapy (ADT). However, subsequent sequences of treatments in real-world settings that may improve overall survival remain an area of active investigation.

Materials and methods
Data were collected from 384 patients presenting with de novo metastatic prostate cancer from 2011 to 2015 at a tertiary cancer center. Patients were categorized into surviving (n = 232) and deceased (n = 152) groups at the end of 3 years. Modified sequence pattern mining techniques (Generalized Sequential Pattern Mining and Sequential Pattern Discovery using Equivalence Classes) were applied to determine the exact order of the most frequent sets of treatments in each group.

Results
Degarelix, as the initial form of ADT, was uniquely in the surviving group. The sequence of ADT followed by abiraterone and docetaxel was uniquely associated with a higher 3-year overall survival. Orchiectomy followed by fosfestrol was found to have a unique niche among surviving patients with a long duration of response to the initial ADT. Patients who received chemotherapy followed by radiotherapy and those who received radiotherapy followed by chemotherapy were found more frequently in the deceased group.

Conclusions
We identified unique treatment sequences among surviving and deceased patients at the end of 3 years. Degarelix should be the preferred form of ADT. Patients who received ADT followed by abiraterone and chemotherapy showed better results. Patients requiring palliative radiation and chemotherapy in any sequence were significantly more frequent in the deceased group, identifying the need to offer such patients the most efficacious agents and to target them in clinical trial design.
Trauma in childhood is associated with greater pain catastrophizing but not anxiety sensitivity: a cross-sectional study
Authors: Delgado-Sanchez Ariane , Brown Christopher , Charalambous Christiana , Sivan Manoj , Jones Anthony 
Published: June 2023

Abstract

Introduction:
Adverse life experiences have been identified as a possible vulnerability factor for chronic pain. This association could result from the effect of trauma on the psychological state of individuals. Previous studies found childhood trauma to be associated with pain catastrophizing and anxiety sensitivity, both of which have been associated with an increased risk of chronic pain. However, it is unknown whether trauma in adulthood affects these variables and whether the effect on pain catastrophizing is independent of confounds such as depression and anxiety.

Objectives:
To test the effect of childhood and adulthood trauma on pain catastrophizing and anxiety sensitivity whilst controlling for depression and anxiety.

Methods:
In the current study, we conducted an online survey in the United Kingdom in a chronic pain sample (N = 138; 123 women; age range 19–78). We analysed whether there is an association between different types of trauma (both in childhood and through the lifespan), pain catastrophizing, and anxiety sensitivity while controlling for anxiety and depression.

Results:
We found that childhood trauma (particularly emotional abuse) significantly predicts pain catastrophizing, even when controlling for depression and anxiety, whereas it did not have a significant effect on anxiety sensitivity. Trauma through the lifespan (not childhood) did not have a significant effect on anxiety sensitivity nor did it have a significant effect on pain catastrophizing.

Conclusions:
Our results show that the life stage in which trauma occurs is key in its psychological effects on patients with chronic pain. Furthermore, it shows that trauma affects some psychological variables but not others.
A pseudovirus-based method to dynamically mimic SARS-CoV-2-associated cell-to-cell fusion and transmission
Authors: Sheng Xiangpeng , Yang Yi , Zhu Fang , Yang Fan , Wang Honghua , Hu Ronggui 
Published: June 2023

AbstractSARS-CoV-2 has caused the global tremendous loss and continues to evolve to generate variants. Entry of SARS-CoV-2 into the host cells is primarily mediated by Spike (S), which binds to the host receptor hACE2 and initiates virus-cell membrane fusion. Cell fusion contributes to viral entry, cell-to-cell transmission and tissue damage in COVID-19 patients. Many reporter assays have been developed to study S-mediated cell fusion by equally coculturing S-expressing cells and hACE2-positive cells. However, these strategies cannot fully simulate cell-to-cell fusion and transmission of SARS-CoV-2 infection, in which virions from a single target cell transmit to the neighbor cells and induce syncytia formation. Here, we design a pseudovirus-based method to dynamically mimic cell-to-cell fusion and transmission of SARS-CoV-2. We coculture a small number of pseudovirus-producing 293FT cells and a large number of hACE2-expressing 293T cells, and demonstrate that a single cell producing S-pseudotyped virions can induce significant syncytia of hACE2-positive cells. This pseudovirus-based method is a powerful tool to screen and estimate potential inhibitors of S-driven syncytia. Moreover, this strategy can also be utilized to explore fusogenic ability of SARS-CoV-2 variants. Together, the pseudovirus-based method we report here will be beneficial to drug screening and scientific research against SARS-CoV-2 or future emerging coronavirus.
Compensation between FOXP transcription factors maintains proper striatal function
Authors: Ahmed Newaz I. , Khandelwal Nitin , Anderson Ashley G. , Kulkarni Ashwinikumar , Gibson Jay , Konopka Genevieve 
Published: June 2023

AbstractSpiny projection neurons (SPNs) of the striatum are critical in integrating neurochemical information to coordinate motor and reward-based behavior. Mutations in the regulatory transcription factors expressed in SPNs can result in neurodevelopmental disorders (NDDs). Paralogous transcription factorsFoxp1andFoxp2, which are both expressed in the dopamine receptor 1 (D1) expressing SPNs, are known to have variants implicated in NDDs. Utilizing mice with a D1-SPN specific loss ofFoxp1,Foxp2, or both and a combination of behavior, electrophysiology, and cell-type specific genomic analysis, loss of both genes results in impaired motor and social behavior as well as increased firing of the D1-SPNs. Differential gene expression analysis implicates genes involved in autism risk, electrophysiological properties, and neuronal development and function. Viral mediated re-expression ofFoxp1into the double knockouts was sufficient to restore electrophysiological and behavioral deficits. These data indicate complementary roles betweenFoxp1andFoxp2in the D1-SPNs.
High density SNP array and reanalysis of genome sequencing uncovers CNVs associated with neurodevelopmental disorders in KOLF2.1J iPSCs
Authors: Gracia-Diaz Carolina , Perdomo Jonathan E. , Khan Munir E. , Disanza Brianna , Cajka Gregory G. , Lei Sunyimeng , Gagne Alyssa , Maguire Jean Ann , Roule Thomas , Shalem Ophir , Bhoj Elizabeth J. , Ahrens-Nicklas Rebecca C. , French Deborah , Goldberg Ethan M. , Wang Kai , Glessner Joseph , Akizu Naiara 
Published: June 2023

SummaryThe KOLF2.1J iPSC line was recently proposed as a reference iPSC to promote the standardization of research studies in the stem cell field. Due to overall good performance differentiating to neural cell lineages, high gene editing efficiency, and absence of genetic variants associated to neurological disorders KOLF2.1J iPSC line was particularly recommended for neurodegenerative disease modeling. However, our work uncovers that KOLF2.1J hPSCs carry heterozygous small copy number variants (CNVs) that causeDTNBP1, JARID2andASTN2haploinsufficiencies, all of which are associated with neurological disorders. We further determine that these CNVs arosein vitroover the course of KOLF2.1J iPSC generation from a healthy donor-derived KOLF2 iPSC line and affect the expression of DNTBP1, JARID2 and ASTN2 proteins in KOLF2.1J iPSCs and neural progenitors. Therefore, our study suggests that KOLF2.1J iPSCs carry genetic variants that may be deleterious for neural cell lineages. This data is essential for a careful interpretation of neural cell studies derived from KOLF2.1J iPSCs and highlights the need for a catalogue of iPSC lines that includes a comprehensive genome characterization analysis.
Need of wastewater purification for sustainability: A mini review
Authors: Girigoswami Agnishwar , Govindharaj Poornima , Mitra Ghosh Mahashweta , Girigoswami Koyeli 
Published: June 2023

AbstractPurpose In addition to agriculture, energy production, and industries, potable water plays a significant role in many fields, further increasing the demand for potable water. Purification and desalination play a major role in meeting the need for clean drinking water. Clean water is necessary in different areas, such as agriculture, industry, food industries, energy generation and in everyday chores.Design/methodology/approach The authors have used the different search engines like Google Scholar, Web of Science, Scopus and PubMed to find the relevant articles and prepared this mini review.Findings The various stages of water purification include coagulation and flocculation, coagulation, sedimentation and disinfection, which have been discussed in this mini review. Using nanotechnology in wastewater purification plants can minimize the cost of wastewater treatment plants by combining several conventional procedures into a single package.Social implications In society, we need to avail clean water to meet our everyday, industrial and agricultural needs. Purification of grey water can meet the clean water scarcity and make the environment sustainable.Originality/value This mini review will encourage the researchers to find out ways in water remediation to meet the need of pure water in our planet and maintain sustainability.
Matching, not merging: how change agents deal with multiple organisation concepts
Authors: Berg Christopher , Benders Jos , Ingvaldsen Jonas A. 
Published: June 2023

Purpose
Organisation concepts consist of prescriptive ideas concerning how to manage or organise. The simultaneous use of multiple concepts in an organisation may create synergies but also confusion and conflicts. This paper aims to explore how change agents deal with the simultaneous use of multiple organisation concepts within a single organisation.

Design/methodology/approach
A qualitative case study of a Norwegian energy company using lean, agile and design thinking.

Findings
The findings show that change agents compare the concepts with each other and recognise commonalities and differences. They also match individual concepts and tools to the nature of tasks, the different phases of projects/initiatives based on their perceived maturity or internal communities. Most agents emphasise similarities between concepts and complementarities between tools. This approach creates a versatile toolbox for improvement.

Practical implications
Companies making use of multiple organisation concepts should continuously discuss and actively manage the tensions that exist between concepts while establishing a unified approach and common culture for improvement.

Originality/value
This study offers a novel understanding of how change agents make sense of different approaches to improvement within a single organisation.
Analysis of dynamic characteristics of liquid-lubricated mechanical face seals with inclined elliptical grooves
Authors: Fuyu Liu , Bo Yu , Yongfan Li , Baojie Ren , Muming Hao , Zhentao Li , Xiaozu Li 
Published: June 2023

Purpose
The purpose of this paper is to study the dynamic characteristics of mechanical face seals with liquid-lubricated inclined elliptical grooves.

Design/methodology/approach
The steady-state and perturbation Reynolds control equations of liquid films were established. The film pressure and the liquid film dynamic coefficients were obtained, impacts of groove structures on the liquid film dynamic characteristic coefficients were analyzed.

Findings
The analysis results indicate that the axial dynamic stiffness and damping coefficients of the liquid film seal with inclined elliptical grooves are far greater than those of the angular directions. Furthermore, the dynamic stiffness coefficient of the liquid film with the nonclosed inclined elliptical grooves is higher than those with the closed grooves, whereas the dynamic damping coefficient of the liquid film is lower.

Originality/value
The effects of inclined elliptical groove structures on the dynamic characteristics of the liquid film seal are investigated. The results presented are expected to enrich the theoretical basis of optimizing the dynamic performance of liquid film seals with textures.