bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of anion exchange resin for sorption of selenium (IV) from aqueous solutions
Authors: El-Tantawy A. , Abu Elgoud E. M. , Sharaf El-Deen S. E. A. 
Published: January 2025

AbstractIn this work, selenium (IV) ions were adsorbed from aqueous solutions by the strongly basic anion exchange resin Amberlite IRA-400. The morphology of the resin before and after Se(IV) sorption was investigated using different techniques such as energy dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). To determine the ideal sorption conditions, a batch approach was used to examine the variables affecting Se(IV) sorption performance, including pH, shaking time, adsorbent dosage, initial metal ion concentration, and temperature. The results showed the optimal parameters for the highest percentage of selenium (80.25%) at an initial concentration of 100.0 mg L−1, pH 3.0, the adsorbent dosage of 10.0 mg, and the shaking time of 60.0 min. According to the experimental findings, the sorption process was satisfactorily explained by the pseudo-second-order kinetic model. The maximum adsorption capacity at pH 3.0 was 18.52 mg g−1, and the adsorption rather well followed the Langmuir adsorption isotherm. Moreover, exothermic and spontaneous sorption reaction was the result of thermodynamic properties (negativity of both ΔG° and ΔH°). The adsorption phase's random distribution of the resin-solution interface is indicated by the positive value of ΔSo. Finally, the desorption study was performed using different concentrations of desorbing agents; HNO3, HCl, and sodium acetate. The results illustrated that the effective desorbing agent was 1.0 mol L-1 HNO3, with desorption efficiency reaching about 96.4%. Finally, the Amberlite IRA-400 demonstrated excellent adsorption–desorption behavior over five times, suggesting that the Amberlite IRA-400 could be an effective candidate for the sorption of Se(IV) from several metal ions that occur in fission products.
Advancements in corrected Euler–Maclaurin-type inequalities via conformable fractional integrals
Authors: Acar Yaren , Budak Hüseyin , Bas Umut , Hezenci Fatih , Yıldırım Hüseyin 
Published: January 2025

AbstractIn this research article, equality is proved to obtain corrected Euler–Maclaurin-type inequalities. Using this identity, we establish several corrected Euler–Maclaurin-type inequalities for the case of differentiable convex functions by means of conformable fractional integrals. Moreover, some corrected Euler–Maclaurin-type inequalities are given for bounded functions by fractional integrals. Additionally, fractional corrected Euler–Maclaurin-type inequalities are constructed for Lipschitzian functions. Finally, corrected Euler–Maclaurin-type inequalities are considered by fractional integrals of bounded variation.
Psychosocial risks and mental health of preschool care providers in Kuala Lumpur, Malaysia: a cross-sectional study
Authors: Tham Sin Wan , Wong Min Fui , Ismail Maslinor Binti , Ismail Bukhary Noriklil Bukhary Binti 
Published: January 2025

Abstract
Background
Child maltreatment in daycare is a public health issue. As childcare is stressful, high care provider negativity independently predicts more internalizing behaviour problems, affecting children’s psycho-neurological development. This study aimed to determine psychosocial factors associated with the mental health of preschool care providers in Kuala Lumpur.

Methods
A random cluster sampling cross-sectional survey was conducted in 2019. The study involved registered care providers for preschoolers under four years old without acute psychiatric illness. The Center for Epidemiologic Studies Depression Scale (Malay-CES-D) and Karasek’s Job Content Questionnaires (Malay-JCQ) were used to assess depression symptoms and psychosocial job-related risks. Logistic regression (p < 0.05) guided by the Hosmer-Lemeshow strategy was used for analysis, with the final model evaluated for assumptions and goodness-of-fit.

Results
A total of 247 providers were recruited from 36 preschools. All respondents were females, with a mean age of 32.1 years old, Malays (70.4%), married (55.0%), attained a diploma and above (50.6%) and had low income (80.1%). The prevalence of depressive symptoms and job strain was 28.7%. Final logistic regression revealed individual factors (married, stressful life events: assault and marital issues), job strain (AOR = 2.33, CI = 1.22, 4.44), and job insecurity (AOR = 1.29, CI = 1.07, 1.56) determine depressive symptoms. Good supervisor support was inversely associated with depression.

Conclusions
Job strain and insecurity contribute significantly to depressive symptoms among preschool care providers in Kuala Lumpur. The Social and Welfare Department can promote supportive supervision through skill training for supervisors, fostering a positive mental health environment for improving workers’ mental health.
Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients
Authors: Cheng Tzu-Chun , Hung Mien-Chie , Wang Lu-Hai , Tu Shih-Hsin , Wu Chih-Hsiung , Yen Yun , Chen Chi-Long , Whang-Peng Jacqueline , Lee Wen-Jui , Liao You-Cheng , Lee Yu-Ching , Pan Min-Hsiung , Lin Hui-Kuan , Tzeng Huey-En , Guo Peixuan , Chu Cheng-Ying , Chen Li-Ching , Ho Yuan-Soon 
Published: January 2025

Abstract
Background
Up to 23% of breast cancer patients recurred within a decade after trastuzumab treatment. Conversely, one trial found that patients with low HER2 expression and metastatic breast cancer had a positive response to trastuzumab-deruxtecan (T-Dxd). This indicates that relying solely on HER2 as a single diagnostic marker to predict the efficacy of anti-HER2 drugs is insufficient. This study highlights the interaction between histamine N-methyltransferase (HNMT) and HER2 as an adjunct predictor for trastuzumab response. Furthermore, modulation of HER2 expression by HNMT may explain why those with low HER2 expression still respond to T-Dxd.

Methods
We investigated the impact of HNMT protein expression on the efficacy of anti-HER2 therapy in both in vivo and ex vivo models of patient-derived xenografts and cell line-derived xenografts. Our analysis included Förster resonance energy transfer (FRET) to assess the interaction strength between HNMT and HER2 proteins in trastuzumab-resistant and sensitive tumor tissues. Additionally, we used fluorescence lifetime imaging microscopy (FLIM), cleaved luciferase, and immunoprecipitation to study the interaction dynamics of HNMT and HER2. Furthermore, we evaluated the influence of HNMT activity on the binding of anti-HER2 antibodies to their targets through flow cytometry. We also observed the nuclear translocation of HNMT/HER2-ICD cells using fluorescent double staining and DeltaVision microscopy. Finally, ChIP sequencing was employed to identify target genes affected by the HNMT/HER2-ICD complex.

Results
This study highlights HNMT as a potential auxiliary biomarker for diagnosing HER2 + breast cancer. FRET analysis demonstrated a significant interaction between HNMT and HER2 protein in trastuzumab-sensitive tumor tissue (n = 50), suggesting the potential of HNMT as a predictor of treatment response. Mechanistic studies revealed that the interaction between HNMT and HER2 contributes to increased HER2 protein expression at the transcriptional level, thereby impacting the efficacy of anti-HER2 therapy. Furthermore, a subset of triple-negative breast cancers characterized by HNMT overexpression was found to be sensitive to HER2 antibody–drug conjugates such as T-Dxd.

Conclusions
These findings offer crucial insights for clinicians evaluating candidates for anti-HER2 therapy, especially for HER2-low breast cancer patients who could gain from T-Dxd treatment. Identifying HNMT expression could help clinicians pinpoint patients who would benefit from anti-HER2 therapy.
Upper Leg Muscular Co-Contraction During Maximal-Speed Sprinting in Male Club Ice Hockey Athletes
Authors: Williams Jason J. , Roshinski William C. , Watso Joseph C. 
Published: January 2025

Abstract
Background
Little is known about the lower extremity muscle co-contraction patterns during sprinting and its relation to running velocity (i.e., performance). Therefore, we compared lower extremity muscular activation patterns during sprinting between slower and faster collegiate club hockey athletes. We hypothesized that faster athletes would have lower EMG-assessed co-contraction index (CCI) values in the lower extremities during over-ground sprinting.

Methods
Twenty-two males (age = 21 [1] yrs (median[IQR]); body mass = 77.1 ± 8.6 kg (mean ± SD)) completed two 20-m over-ground sprints with concomitant EMG and asynchronous force plate testing over four days in Tallahassee, Florida, USA. We split participants using median running velocity (FAST: 8.5 ± 0.3 vs. SLOW: 7.7 ± 0.3 m/s, p < 0.001).

Results
Faster athletes had lower CCI between the rectus femoris and biceps femoris (group: p = 0.05), particularly during the late swing phase of the gait cycle (post hoc p = 0.02). Early swing phase duration was moderately inversely related to Hip CCI in the stance phase (ρ=-0.58, p < 0.01) and weakly related to Knee CCI in the swing phase (ρ = 0.44, p = 0.046). Finally, swing phase duration was moderately inversely related to Hip CCI in the stance phase (ρ=-0.50, p = 0.02).

Conclusions
In agreement with our hypothesis, we found lower CCI values in the upper leg musculature during maximal-speed over-ground sprinting. These data from collegiate club hockey athletes corroborate other reports in clinical populations that the coordination between the rectus femoris and biceps femoris is associated with linear over-ground sprinting velocity.
Multi-omics integration and immune profiling identify possible causal networks leading to uterine microbiome dysbiosis in dairy cows that develop metritis
Authors: Casaro S. , Prim J. G. , Gonzalez T. D. , Cunha F. , Silva A. C. M. , Yu H. , Bisinotto R. S. , Chebel R. C. , Santos J. E. P. , Nelson C. D. , Jeon S. J. , Bicalho R. C. , Driver J. P. , Galvão Klibs N. 
Published: January 2025

Abstract
Background
Cows that develop metritis experience dysbiosis of their uterine microbiome, where opportunistic pathogens overtake uterine commensals. An effective immune response is critical for maintaining uterine health. Nonetheless, periparturient cows experience immune dysregulation, which seems to be intensified by prepartum over-condition. Herein, Bayesian networks were applied to investigate the directional correlations between prepartum body weight (BW), BW loss, pre- and postpartum systemic immune profiling and plasma metabolome, and postpartum uterine metabolome and microbiome.

Results
The Bayesian network analysis showed a positive directional correlation between prepartum BW, prepartum BW loss, and plasma fatty acids at parturition, suggesting that heavier cows were in lower energy balance than lighter cows. There was a positive directional correlation between prepartum BW, prepartum systemic leukocyte death, immune activation, systemic inflammation, and metabolomic changes associated with oxidative stress prepartum and at parturition. Immune activation and systemic inflammation were characterized by increased proportion of circulating polymorphonuclear cells (PMN) prepartum, B-cell activation at parturition, interleukin-8 prepartum and at parturition, and interleukin-1β at parturition. These immune changes together with plasma fatty acids at parturition had a positive directional correlation with PMN extravasation postpartum, which had a positive directional correlation with uterine metabolites associated with tissue damage. These results suggest that excessive PMN migration to the uterus leads to excessive endometrial damage. The aforementioned changes had a positive directional correlation with Fusobacterium, Porphyromonas, and Bacteroides in cows that developed metritis, suggesting that excessive tissue damage may disrupt physical barriers or increase substrate availability for bacterial growth.

Conclusions
This work provides robust mechanistic hypotheses for how prepartum BW may impact peripartum immune and metabolic profiles, which may lead to uterine opportunistic pathogens overgrowth and metritis development.
Investigation of peripheral markers of inflammation in patients with different diagnoses on the psychosis spectrum: an observational cross-sectional study
Authors: Üstün Ezgi Sıla Ahi , Yazıcı Serkan , İlhan Rifat Serav , Can Kazım Cihan , Saka Meram Can 
Published: January 2025

Abstract
Background
Increasing evidence suggests that inflammatory dysfunction may be important across the psychotic spectrum. In this study, we investigated whether there is a difference between different diagnostic groups, in which psychosis is the common pathway, and healthy controls in markers of peripheral inflammation, such as platelet-lymphocyte ratio (PLR), neutrophil–lymphocyte ratio (NLR), systemic inflammatory response index (SIRI) and systemic immune-inflammatory index (SII), determined by haemogram. Our hypotheses are as follows: patients with a common history of psychosis but with different diagnoses have higher severity of peripheral inflammation compared to healthy controls, regardless of the specific diagnosis. In addition, the severity of peripheral inflammation is similar across different diagnoses across the psychosis spectrum.

Results
Before and after correction for age and sex, there was no statistically significant difference in PLR between the groups. However, a substantial statistical difference in NLR and SIRI was observed between the groups. According to the post hoc analysis performed to determine which groups the difference was between, schizophrenia and the healthy control group, schizoaffective disorder and the healthy control group, and autism spectrum disorder and the healthy control group differed in terms of NLR; there was only a significant difference in SIRI between autism spectrum disorder and the healthy control group. In addition, there was a statistically significant difference between groups for SII before and after correction for age and sex; however, when paired groups were evaluated using post hoc analysis, no statistically significant differences were found between any two groups. When comparing disorder groups within the psychotic spectrum, it was observed that PLR, NLR, SIRI, and SII levels were comparable.

Conclusions
Our results showed that several disorders including schizophrenia, schizoaffective disorder and autistic spectrum disorder, with different diagnoses but similarities in terms of a history of psychosis, had increased inflammation compared to healthy controls. This study contributes to the psychosis spectrum approach in that there was no statistically significant difference in the severity of inflammation in disorder groups with a history of psychosis but with different diagnostic categories. However, further research is needed to completely understand the psychosis spectrum, as bipolar disorder patients have similar inflammation levels to those without mental disorders.
Synthesis and anti-microbial evaluation with in silico studies of novel 2-aminothiazole benzohydrazide derivatives
Authors: Amrutha S. , Das Paramita , Nayak Anjali , Laha Supratip , Begum Sharmina , Bhardwaj Sakshi 
Published: January 2025

Abstract
Background
The development of novel anti-microbial drugs for multidrug-resistant (MDR) is a significant challenge. This study aimed to synthesize various derivatives of (Z)-4-(2-aminothiazol-5-yl)-N-benzohydrazide (DT01-DT10) that are effective against a wide variety of anti-bacterial and antifungal pathogens.

Results
The binding energy of the compounds ranged from − 9.0 to − 10.0 kcal/mol. Molecular simulations produced a major result in improving the representation of the real biological conditions with an average RMSD of 0.110 nm. The derivatives DT03, DT04, and DT06 showed overall good anti-microbial activity at lower concentrations of 1.8 µg/ml. Compound DT03 showed significant activity against Gram-positive, Gram-negative bacteria and fungal strains, with inhibition zone diameters of 17, 19 and 16 mm, respectively. Compound DT04 showed promising anti-bacterial effects against S.mutans and C.albicans, with inhibition zone diameters of 18 and 17 mm, and moderate activity against B. cereus. Compound DT06 showed enhanced activity against P.aeruginosa.

Conclusion
The derivative 4-(2-amino-1,3-thiazol-5-yl)-N′-(Z)-(2-nitrophenyl) methylidene benzohydrazide (DT06), which contained a nitro group displayed potent activity at 1.8 µg/ml with an IC50 of 50.31 and a selectivity index of 61.33.

Graphical abstract
Investigating the pre- and post-COVID-19 vaccination infection status of Iranian dental students: a cross-sectional study
Authors: Owlia Fatemeh , Kargar Mohammad-Javad , Kazemipoor Maryam 
Published: January 2025

Abstract
Background
Dental students face a potential risk of COVID-19 exposure due to close patient contact and aerosol-generating procedures. This study explores the frequency of COVID-19 infection among Iranian dental students in 2022 following different vaccination doses.

Methods
A cross-sectional study was used to collect self-reported COVID-19 status. A total of 261 dental students volunteered to participate in the study. A total of 252 valid forms were gathered, with a response rate of 96.55%. Data analysis was performed using descriptive statistics, mean and standard deviation, and chi-square and Fisher exact tests by Spss17 (Chicago, USA) software.

Results
The rate of COVID-19 infection significantly decreased after the first and third doses of vaccination. The rate of COVID-19 infection was not very different after the first, second, and third doses of the vaccine according to the type of vaccine. Despite no significant difference in COVID-19 infection rates between genders, study years, or vaccine types (excluding AstraZeneca), participants who received the AstraZeneca vaccine experienced more serious side effects compared to those who received other vaccines.

Conclusion
Vaccination appeared to reduce the rate of COVID-19 infection among dental students and may have decreased the duration of infection following different vaccine doses. There was no significant difference in infection rates based on the type of vaccine received. Further research is needed to investigate the potential side effects and long-term effectiveness of COVID-19 vaccines.
The impact of the live broadcast of Stromae’s song L’enfer on social media publications, calls to the national helpline, and suicide attempt rates in France
Authors: Notredame Charles-Edouard , Saint-Dizier Chloé , Lamer Antoine , Nogue Erika , Fares Emile , Lemdani Mohamed , Vaiva Guillauma , Courtet Philippe , Olié Emilie 
Published: January 2025

Abstract
On January 9, 2022, Belgian pop singer Stromae performed his new hit “L’enfer” live on French TV. The song addresses his personal struggles with suicidal ideation. To evaluate the impact of Stromae’s performance, we modeled the evolution of hospital admission rates for suicide attempts (SAs) in France, calls to the national suicide prevention helpline (3114), and Twitter publications mentioning the singer or the helpline. We employed the Gombay test to identify change points within each time series. We identified a significant increase in mean SA rates among women aged 20–24 years 6 days after the singer’s performance. No similar effect was observed in the general population or other young age groups. The show was immediately followed by a peak in tweets referring to the singer, while Twitter activity related to the 3114 remained modest. We did not observe any increase in calls to the helpline. Celebrity testimonies about suicidal experiences can help alleviate stigma but should be accompanied by prevention messages to reduce the risk of contagion.
Food for Cancer Health Equity: A Qualitative Study Among People With Cancer Who Are Low-Income, Latino or Hispanic, Immigrant, and Individuals With Multiple Minoritized Races and Ethnicities
Authors: Hanna Maria , Wood Emily H. , Noyola Perez Andrés , Villicana Gerardo , Guzman Lesly Lopez , Reynaga Jajaira , Trotter Chardria , Koontz Zachary M. , Patel Manali I. 
Published: January 2025

PURPOSE
Food insecurity is prevalent among patients with cancer. Gaps in our understanding of preferences for food assistance among Latino or Hispanic, immigrant, and people with multiple races and ethnicities limit uptake of food assistance interventions among these populations. We aimed to deeply understand the needs and preferences and barriers to food assistance intervention uptake among low-income, predominantly Latino or Hispanic, immigrant, and people with multiple races and ethnicities and cancer to inform development of tailored interventions.

METHODS
Participants were recruited among low-income adult patients with cancer who screened positive for food insecurity using the two-item Hunger Vital Sign as part of an ongoing parent randomized controlled trial evaluating a precision medicine intervention. Semi-structured interviews were conducted to assess dietary habits, barriers to food security, and preferences for intervention. Interview responses were transcribed, translated, and thematically analyzed using an inductive-deductive iterative approach.

RESULTS
Among 40 (36.4%) participants in the parent randomized trial who screened positive for food insecurity, 20 (50%) were randomly selected to participate in this study. The mean age of participants was 56 years, 17 (85%) self-identified as Latino or Hispanic, 17 (85%) identified Spanish as their preferred language, 13 (65%) reported annual household income <$34,000 in US dollars, and 12 (60%) were unemployed. Three main themes emerged: (1) individualized nutritional needs and culturally specific food preferences; (2) financial, logistical, and emotional barriers to food security; and (3) self-efficacy, autonomy, and approaches to reduce stigma in food assistance interventions.

CONCLUSION
Assessing and integrating the needs and preferences for food assistance is crucial for the development and uptake of food assistance interventions among Latino or Hispanic, immigrant, and other racial and ethnic minoritized individuals with cancer.