bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutant p53 leads to low‐grade IFN‐I‐induced inflammation and impairs cGAS–STING signalling in mice
Authors: Qin Ziyi , Liu Huan , Sheng Qihuan , Dan Juhua , Wu Xiaoming , Li Hao , Wang Lulin , Zhang Shuojie , Yuan Chao , Yuan Hongjun , Wang Hui , Zhou Ruoyu , Luo Ying , Xie Xiaoli 
Published: June 2023

AbstractType I interferons (IFN‐Is) are a class of proinflammatory cytokines produced in response to viruses and environmental stimulations, resulting in chronic inflammation and even carcinogenesis. However, the connection between IFN‐I and p53 mutation is poorly understood. Here, we investigated IFN‐I status in the context of mutant p53 (p53N236S, p53S). We observed significant cytosolic double‐stranded DNA (dsDNA) derived from nuclear heterochromatin in p53S cells, along with an increased expression of IFN‐stimulated genes. Further study revealed that p53S promoted cyclic GMP‐AMP synthase (cGAS) and IFN‐regulatory factor 9 (IRF9) expression, thus activating the IFN‐I pathway. However, p53S/S mice were more susceptible to herpes simplex virus 1 infection, and the cGAS–stimulator of IFN genes (STING) pathway showed a decline trend in p53S cells in response to poly(dA:dT) accompanied with decreased IFN‐β and IFN‐stimulated genes, whereas the IRF9 increased in response to IFN‐β stimulation. Our results illustrated the p53S mutation leads to low‐grade IFN‐I‐induced inflammation via consistent low activation of the cGAS–STING‐IFN‐I axis, and STAT1‐IRF9 pathway, therefore, impairs the protective cGAS–STING signalling and IFN‐I response encountered with exogenous DNA attack. These results suggested the dual molecular mechanisms of p53S mutation in inflammation regulation. Our results could be helping in further understanding of mutant p53 function in chronic inflammation and provide information for developing new therapeutic strategies for chronic inflammatory diseases or cancer.
Transinteractome analysis reveals distinct niche requirements for isotype‐based plasma cell subsets in the bone marrow
Authors: Bonaud Amélie , Larraufie Pierre , Khamyath Mélanie , Szachnowski Ugo , Flint Shaun M. , Brunel‐Meunier Nadège , Delhommeau François , Munier Annie , Lönnberg Tapio , Toffano‐Nioche Claire , Gautheret Daniel , Balabanian Karl , Espéli Marion 
Published: June 2023

AbstractBone marrow (BM) long‐lived plasma cells (PCs) are essential for long‐term protection against infection, and their persistence within this organ relies on interactions with Cxcl12‐expressing stromal cells that are still not clearly identified. Here, using single cell RNAseq and in silico transinteractome analyses, we identified Leptin receptor positive (LepR+) mesenchymal cells as the stromal cell subset most likely to interact with PCs within the BM. Moreover, we demonstrated that depending on the isotype they express, PCs may use different sets of integrins and adhesion molecules to interact with these stromal cells. Altogether, our results constitute an unprecedented characterization of PC subset stromal niches and open new avenues for the specific targeting of BM PCs based on their isotype.
Cholesterol‐autoxidation metabolites in host defense against infectious diseases
Authors: Shi Qiwen , Zhan Tingzhu , Bi Xiaobao , Ye Bang‐ce , Qi Nan 
Published: June 2023

AbstractCholesterol plays essential roles in biological processes, including cell membrane stability and myelin formation. Cholesterol can be metabolized to oxysterols by enzymatic or nonenzymatic ways. Nonenzymatic cholesterol metabolites, also called cholesterol‐autoxidation metabolites, are formed dependent on the oxidation of reactive oxygen species (ROS) such as OH• or reactive nitrogen species, such as ONOO−. Cholesterol‐autoxidation metabolites are abundantly produced in diseases such as inflammatory bowel disease and atherosclerosis, which are associated with oxidative stress. Recent studies have shown that cholesterol‐autoxidation metabolites can further regulate the immune system. Here, we review the literature and summarize how cholesterol‐autoxidation metabolites, such as 25‐hydroxycholesterol (25‐OHC), 7α/β‐OHC, and 7‐ketocholesterol, deal with the occurrence and development of infectious diseases through pattern recognition receptors, inflammasomes, ROS production, nuclear receptors, G‐protein‐coupled receptor 183, and lipid availability. In addition, we include the research regarding the roles of these metabolites in COVID‐19 infection and discuss our viewpoints on the future research directions.
Nickelacyclobutanes: Versatile Reactivity and Role as Catalytic Intermediates
Authors: Sansores‐Paredes María L. G. , Pérez‐García Pablo M. , Moret Marc‐Etienne 
Published: June 2023

AbstractMetallacyclobutanes are intermediates in several catalytic cycles such as olefin metathesis and cyclopropanation. Furthermore, nickel is attracting attention as a versatile, earth‐abundant metal in developing new homogeneous catalytic transformations. In this context, the current literature on nickelacyclobutanes and their role in catalysis is reviewed. First, catalytic reactions involving a (putative) nickelacyclobutane intermediate are discussed, including cyclopropanations and various transformations of methylenecyclopropane. Second, studies of the stoichiometric reactivity of nickelacyclobutanes relying on their direct observation or even isolation are detailed. In particular, the relationship between the structure of nickelacyclobutanes and their reactivity is highlighted. Finally, future prospects for the development of new catalytic transformations relying on nickelacyclobutane intermediates are briefly outlined.
Metal‐Free Oxyacetoxylation of Arylynamines and Ynamides To Construct α‐Acetoxyl Amides
Authors: Long Rong , Huang Shaoling , Wu Han‐Kui , Iqbal Naila , Wu Na 
Published: June 2023

AbstractYnamides/arylynamines are challenging substrates for oxyacetoxylation, especially due to various reactive sites of the N‐heteroaryl ring. Herein, we report a metal‐free PhI(OAc)2‐mediated oxyacetoxylation of arylynamines/ynamides to provide α‐acetoxyl amides in good to excellent yields. The transformation completes in a short time to afford solely the product in a highly regio‐ and chemo‐selective manner through β‐iodo keteneiminium intermediate, without functionalising the N‐heteroaryl moiety.
Base‐Promoted Difunctionalization of Alkynes: One‐Pot Synthesis of Polysubstituted Chromones
Authors: Wang Mengdan , Cheng Lu , Ma Junying , Lu Weiwei , Wang Junling 
Published: June 2023

AbstractA transition‐metal‐free one‐pot procedure for the difunctionalization of alkynes by C−C triple bond oxidation and transformation towards chromone derivatives has been developed. It involves cascade reactions for carbonylation of alkynes, base‐promoted C−C σ‐bond cleavage, and intramolecular cyclization. This procedure provides an efficient protocol for the synthesis of polysubstituted chromones from readily available starting materials.
Fire reaction properties of bio‐based aggregates used in thermally insulated building components
Authors: Rocha Monique , Gomes Bruno , Aguiar Amanda , Landesmann Alexandre , Hasparyk Nicole Pagan , Toledo Filho Romildo 
Published: June 2023

AbstractBio‐based aggregates can be seen as one of the promising alternatives to reduce the environmental impacts of buildings due to their lower carbon footprint and energy efficiency. They have great potential to be incorporated into inorganic matrices and produce insulating materials. However, there is a lack of information about the flammability of these materials. This work presents the results of an experimental investigation of the fire behaviour of bio‐based materials. In this study, wastes of bamboo, wood shavings and rice husk were used and were evaluated for their fire performance in the natural state and after treatment in an alkaline solution. The fire reaction properties were determined by using a Mass Loss Cone Calorimeter in order to obtain the parameters of heat release rate (HRR), total heat released (THR), effective heat of combustion (EHC), total mass loss (TML), ignition time (IT) and time of combustion (TC). In addition, physical characterization and thermogravimetric tests were carried out as well as scanning electron microscopy analyses. The results show that the alkaline treatment of the bio‐based aggregates is able to reduce the average HRR and the EHC of all bio‐aggregates but does not delay the ignition of these materials. Among the residues studied, rice husk presented the lowest peaks and averages of HRR, THR, total mass loss, EHC and time to flameout; however, the ignition occurred faster.
Ergonomic assessment for designing manual material handling tasks at a food warehouse in India: A case study
Authors: Adhaye Amit M. , Jolhe Dhananjay A. 
Published: June 2023

AbstractManual handling of heavy grain bags is a commonplace activity across agriculture produce supply chain. In the present research, a manual material handling involving lifting, lowering, and carrying grain bags along the paths of variable characteristics is critically analyzed to explore the risk associated with it. The humans engaged in this activity are found to be facing discomfort, suffering from pain and musculoskeletal disorders, and undergoing medication for the same. This study proposes and demonstrates a structured ergonomic evaluation methodology to not only assess the level of discomfort/pain but also evaluate risk factors such as load handled, method of handling, frequency of handling, awkward postures, path characteristics, and so on. It employs a systematic multimethod approach consisting of Nordic Musculoskeletal Questionnaire and Borg Rating of Perceived Exertion, Ovako Working posture Assessment System, NIOSH Lifting Equation, Rapid Entire Body Assessment, and Key Indicator Method. The study reveals that about 94% of the sample population suffered from moderate to severe discomfort in ankle, knee, and lower back. Eight basic activities responsible for risky postures are identified. Frequency of handling, weight being handled, back bending/twisting, poor coupling, and walking surface are observed as major contributors to musculoskeletal discomfort. Carrying on shoulder is found to be riskier than carrying on back; however, the risk is found to be significantly lowered by carrying on backpack. The present study identifies the need for task redesign, proper gripping arrangements, auxiliary devices for lifting/carrying, and improvement in the path characteristics.
SLE initially presenting with neuropsychiatric manifestations and seizure, case report
Authors: Khormi Abdulrahman Ali M. , Hijazi Faisal Taher 
Published: June 2023

AbstractSystemic lupus erythematosus (SLE) is a multisystem autoimmune disorder exhibiting variable disease courses and multiple clinical manifestations. SLE's aetiology remains unclear; however, different environmental (e.g., ultraviolet light, infections, drugs, etc.), genetic, and hormonal factors are potentially involved. A positive family history and history of having other autoimmune illnesses are considered high‐risk factors for SLE; nevertheless, most SLE cases are scattered. The 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for SLE include at least one positive antinuclear antibody test as a mandatory entry criterion, followed by additive weighted standards grouped in seven clinical (constitutional, haematological, neuropsychiatric, serosal, musculoskeletal, renal, and mucocutaneous) and three immunological (antiphospholipid antibodies, complement proteins, and SLE‐specific antibodies) domains weighted from 2 to 10, with patients accumulating ≥10 points being diagnosed with SLE. Herein, we report a case of neuropsychiatric lupus, a rare and severe form of SLE.
The Supra‐System Model
Authors: McDermott Tom , Alexander Kelly , Wallace Richard 
Published: June 2023

ABSTRACTThis article presents an initial set of concepts resulting from research by the Office of the Undersecretary of Defense for Research and Engineering (OUSD/RE) and the Systems Engineering Research Center (SERC) under an initiative called “systems engineering modernization” (SEMOD). This article discusses the “supra‐system model,” which evolved as a different view of systems engineering lifecycle activities across the entire life of an engineered system. This view promotes systems engineering as a continuous process that is 1) iterative across the full life of a system and 2) managed through a digital transformation centered on data and models. This article also discusses the value of “shared and authoritatively managed data and models” in the lifecycle of future systems. These together present a modernized view of systems engineering where “seamless and efficient transfer of data and models” will support practices that are “more agile and responsive to changing stakeholder needs.”
Diversification in the tourism sector and economic growth in Australia: a disaggregated analysis
Authors: Solarin Sakiru Adebola , Lasisi Taiwo Temitope , Hossain Md. Emran , Bekun Festus Victor 
Published: June 2023

AbstractIn most countries inclusive of Australia, tourism policies do not only deal with how to diversify tourism markets but also how to diversify tourism activities. Efforts are often made to increase the inflows of tourists from different source markets and to improve arrivals for various tourism activities. However, the existing literature on the economic impact of the diversification of the sector has not dealt with the economic impact of diversification of tourism markets. This study aims to examine the economic impact of diversification of both tourism markets and tourism activities. Using a newly developed tourism diversification index, the focus of the study is on Australia for the period, 1976–2020. Utilizing a dynamic autoregressive lag simulation approach, the results suggest that diversification of tourism markets and activities generated positive economic growth in Australia in line with the notion of tourism‐led growth hypothesis. Empirical results outline that a 1% increase in diversification of tourism markets and activities generated increases in the gross domestic product by 0.010% and 0.070%, respectively. One of the implications of the results is that policies to diversify tourism markets and activities will be beneficial to the economy in Australia.
Morphological and physiological impacts of salinity on colonial strains of the cyanobacteria Microcystis aeruginosa
Authors: Bormans Myriam , Legrand Benjamin , Waisbord Nicolas , Briand Enora 
Published: June 2023

AbstractIn the context of global change and enhanced toxic cyanobacterial blooms, cyanobacterial transfer to estuaries is likely to increase in frequency and intensity and impact animal and human health. Therefore, it is important to evaluate the potential of their survival in estuaries. In particular, we tested if the colonial form generally observed in natural blooms enhanced the resistance to salinity shock compared to the unicellular form generally observed in isolated strains. We tested the impact of salinity on two colonial strains of Microcystis aeruginosa, producing different amounts of mucilage by combining classical batch methods with a novel microplate approach. We demonstrate that the collective organization of these pluricellular colonies improves their ability to cope with osmotic shock when compared to unicellular strains. The effect of a sudden high salinity increase (S ≥ 20) over 5 to 6 days had several impacts on the morphology of M. aeruginosa colonies. For both strains, we observed a gradual increase in colony size and a gradual decrease in intercellular spacing. For one strain, we also observed a decrease in cell diameter with an increase in mucilage extent. The pluricellular colonies formed by both strains could withstand higher salinities than unicellular strains studied previously. In particular, the strain producing more mucilage displayed a sustained autofluorescence even at S = 20, a limit that is higher than the most robust unicellular strain. These results imply survival and possible M. aeruginosa proliferation in mesohaline estuaries.
XRCC1, ABCB1, CYP3A5 and GSTP1 gene polymorphism associated with platinum‐based drugs induced hematotoxicity in Chinese oesophageal cancer patients
Authors: Chen Shuang , Xiao Xiao , Chen Jianliang , Chen Yun , Wang Zixian , Qiu Guodong , Zhang Shuyao , Zhong Shilong 
Published: June 2023

AbstractBackgroundHematotoxicity, including severe myelosuppression, is a common adverse drug reaction (ADR) during platinum‐based treatment for oesophageal cancer (EC).PurposeThe aim of this study was to identify single‐nucleotide polymorphisms (SNPs) associated with platinum‐induced hematotoxicity in patients with EC, as the relationship between SNPs and this ADR is incompletely demonstrated.MethodsA total of 262 patients receiving platinum‐based chemotherapy (cisplatin, nedaplatin, carboplatin and oxaliplatin) were enrolled in this study. Ten SNPs in eight genes were genotyped via multiplex polymerase chain reaction and sequenced to evaluate their relationship with severe myelosuppression and its subset of leukopenia and neutropenia.ResultsMultivariate logistic analysis of cisplatin cohort in severe leukopenia group showed an odds ratio (OR) of GG + GA versus AA in ABCB1 rs1045642 was 5.83 (95% confidence interval (CI) 1.63–20.83, p = 0.007, false discovery rate (FDR) = 0.028), while the OR of AA versus AG + GG in rs1128503 was 0.34 (95% CI 0.14–0.86, p = 0.022, FDR = 0.044). In nedaplatin cohort of neutropenia group, the OR of AA versus GG, AA + AG versus GG in GSTP1 rs1695 was 10.34 (95% CI 1.71–62.40, p = 0.011, FDR = 0.040) and 7.48 (95% CI 1.37–40.81, p = 0.020, FDR = 0.040) respectively. XRCC1 rs1799782 GG genotype in nedaplatin cohort of myelosuppression group and CYP3A5 rs776746 CT genotype in nedaplatin cohort of severe leukopenia group and platinum cohorts of all groups appeared to be risk factors with the p values less than 0.05, but FDR values were all greater than 0.05.ConclusionThis study identified SNPs of XRCC1, ABCB1, CYP3A5 and GSTP1 related to hematotoxicity of platinum‐based drugs, thereby providing a novel theoretical basis for the prediction and prevention of ADRs in platinum‐based chemotherapy.
Accelerated dynamic MR imaging with joint balanced low‐rank tensor and sparsity constraints
Authors: He Jingfei , Mi Chenghu , Liu Xiaotong , Zhao Yuanqing 
Published: June 2023

AbstractBackgroundDynamic magnetic resonance imaging (DMRI) is an essential medical imaging technique, but the slow data acquisition process limits its further development.PurposeBy exploiting the inherent spatio‐temporal correlation of MR images, low‐rank tensor based methods have been developed to accelerate imaging. However, the tensor rank used by these methods is defined by an unbalanced matricization scheme, which cannot capture the global correlation of DMR data efficiently during the reconstruction process.MethodsIn this paper, an effective reconstruction model is proposed to achieve accurate reconstruction by using the tensor train (TT) rank defined by a well‐balanced matricization scheme to exploit the hidden correlation of DMR data and combining sparsity. Meanwhile, the ket augmentation (KA) technology is introduced to preprocess the DMR data into a higher‐order tensor through block structure addressing, which further improves the ability of TT rank to explore the local information of the image. In order to solve the proposed model, the alternating direction method of multipliers (ADMM) is used to decompose the optimization problem into several unconstrained subproblems.ResultsThe performance of the proposed method was validated on the 3D DMR image dataset by using different sampling trajectories and sampling rates. Extensive numerical experiments demonstrate that the reconstruction quality of the proposed method is superior to several state‐of‐the‐art reconstruction methods.ConclusionsThe proposed method successfully utilizes the TT rank to explore the global correlation of DMR images, enabling more detailed information of the image to be captured. Besides, with the sparse priors, the proposed method can further improve the overall reconstruction quality for highly undersampled MR images.
Longitudinal characteristics of insight and clinical factors in patients with schizophrenia
Authors: Sakai Yoshie , Ito Satsuki , Matsumoto Junya , Yasuda Yuka , Yamamori Hidenaga , Fujimoto Michiko , Hasegawa Naomi , Ishimaru Keiichiro , Miura Kenichiro , Hashimoto Ryota 
Published: June 2023

AbstractAimsSchizophrenia is a psychiatric disorder presenting a lack of insight. Although insight changes over time, longitudinal studies of insight in schizophrenia are scarce. Furthermore, most previous studies on insight and intelligence have not measured full‐scale IQ and have not been able to examine the relationship between detailed dimensions of cognitive function and insight. In this study, we assessed insight at two time points and assessed dimensions of cognitive function.MethodsA total of 163 patients with schizophrenia participated in the study. We evaluated insight at two time points to understand the patterns of change and examined the association between insight and clinical variables. Additionally, we examined the relationship between the dimensions of cognitive function and insight.ResultsThe patients were divided into three groups based on their change in insight over time: stable at a low level of insight (poor insight), stable at a high level of insight (good insight), and changed in insight over time (unstable insight). Those in the poor insight group had lower general intelligence scores than those in the good insight and unstable insight groups. Regarding cognitive function, verbal comprehension was associated with the level of insight at baseline and follow‐up. Regarding psychiatric symptoms, the poor insight group exhibited more severe symptoms than the other two groups, especially regarding positive symptoms.ConclusionsOur classification of patients based on changes in insight revealed that poor insight patients had impaired cognitive function, especially verbal comprehension, and more severe positive symptoms than good insight or unstable insight patients.
Neilan's divergence‐free finite elements for Stokes equations on tetrahedral grids
Authors: Zhang Shangyou 
Published: June 2023

AbstractThe Neilan ‐ divergence‐free finite element is stable on any tetrahedral grid, where the piece‐wise polynomial velocity is on the grid, on edges and at vertices, and the piece‐wise polynomial pressure is on edges and at vertices. However the method does not work if the exact pressure solution does not vanish on all domain edges, because of the excessive continuity requirements. We extend the Neilan element by removing the extra requirements at domain boundary edges. That is, if a vertex is on a domain boundary edge and if an edge has one endpoint on a domain boundary edge, the velocity is only at the vertex and on the edge, respectively, and the pressure is totally discontinuous there. Under the condition that no tetrahedron in the grid has more than one face‐triangle on the domain boundary, we prove that the extended finite element is stable, and consequently produces solutions of optimal order convergence for all Stokes problems. A numerical example is given, confirming the theory.