bluuebunny/crossref_metadata_2025_split huggingface dataset:
German Firms in International Trade: Evidence from Recent Microdata
Authors: Fauth Matthias , Jung Benjamin , Kohler Wilhelm 
Published: July 2023

AbstractIn this paper, we zoom in on the firm level of German merchandise foreign trade, using a novel data base with information on the export and import value by firm, country, product and year for the period 2011–2019. Problems arising from the consolidated reporting of taxable entities and the reporting thresholds present in intra-EU trade have been largely eliminated through redistributions conducted by DESTATIS. Using the data, we examine howglobalGerman firms are by looking at the joint distribution of the number of products they trade and the number of countries they trade with. Moreover, we examine the importance of firms mainly engaged in trade intermediation, as opposed to production. Most importantly, we provide a rich description of heterogeneity among German firms by decomposing their trade relationships into intensive margins (value of trade) and extensive margins (number of firms, products and countries). We describe the distributions for each margin, distinguishing intra-EU and extra-EU trade as well as different firm types (producers, wholesalers, retailers). Finally, we reveal strong positive correlations between and within importing and exporting margins, supporting the presence of firm-level complementarities implied by recent theory.
Cognitive and pragmatic features of Anglicisms in Kazakh media text
Authors: Zhussubalina Zhanat , Tleuberdiyev Bolat 
Published: July 2023

Abstract
The use of English words has become a fashionable trend, something that is reflected in journalistic texts and adversely affects the language of Kazakhstan. This study is aimed at investigating the linguistic and cognitive-pragmatic aspects of Anglicisms in media language and media texts in Kazakhstan. The leading methods of investigating this issue are the literary method, the method of cognitive linguistics, methods of classification, induction, deduction, generalisation, and comparison of cultural, socio-psychological and philological approaches, which will help to identify the influence and function of Anglicisms in Kazakhstan. The authors of this study have performed a detailed analysis of the literature and the content, clarifying the characteristics and features of this phenomenon. The study generalises the main inherent features of borrowings in the Kazakh language, describes the functions of borrowings in media texts, demonstrates certain aspects of the communicative potential of Anglicisms, considers the specific features of the influence of these words and phrases on the development of linguistic personality, describes the topics and situations of the use of English borrowings in the media of Kazakhstan, diagnoses the number of these words in media texts, and demonstrates the prospects for the development of this vocabulary in the media resources of Kazakhstan.
CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report
Authors: Hu Hongtao , Xu Lei , Guo Xiang , Teng Haijun , Liu Wenhua 
Published: July 2023

Abstract
Metastatic diseases of the spine are becoming increasingly common with an aging population and improvements in systemic cancer therapies. Microwave and vertebroplasty are the mainstay modalities for treating painful spine metastases. Most early spinal metastases predominantly attack the adnexa, but there are few reports on its treatment. This report presents a case of a 56-year-old female who had experienced severe thoracic back pain for several days and was diagnosed with a metastatic tumor of the right transverse process of T7. Percutaneous microwave ablation in combination with bone cement injection was used to treat the metastatic tumor under CT guidance. The postoperative pain on the Visual Analogue Scale was 1/10, without nerve or vessel damage and bone cement leakage during the operation.
The crystal structure of 3-(2-hydroxyphenyl)-4-phenyl-6-(p-tolyl)-2H-pyran-2-one, C24H18O3
Authors: Wang Mengdan , Wang Junling , Guo Yafei , Lu Weiwei , Luo Jie , Ma Jun-Ying 
Published: July 2023

Abstract
C24H18O3, monoclinic, P21/c (no. 14), a = 9.0474(7) Å, b = 19.9648(12) Å, c = 10.7153(3) Å, β = 104.175(2)°, V = 1876.6(3) Å3, Z = 4, R

gt
(F) = 0.0459, wR

ref
(F
2) = 0.1183, T = 296 K.
Development of a gray box system identification model to estimate the parameters affecting traffic accidents
Authors: Zargari Shahriar Afandizadeh , Rad Hamid Bigdeli 
Published: July 2023

Abstract
In this study, the gray box method has been used to model traffic accidents for the first time. This work examines the problem of estimating and identifying a single-input single-output state-space system. In this way, the state-space model was used, which has both a black box section (experimental data) and the parameters have been estimated by acquiring prior knowledge (white box). First, the state-space of the desired system is formed, and the algorithm for estimating the parameters and their convergence and the state vector estimation algorithm are written. In comparison, the system changes from nonlinear to linear. The parameters and prior knowledge are entered from the system. Finally, by implementing the presented method on the data related to the factors affecting accidents in Qazvin (Iran), the accuracy of the presented materials is investigated. The error output shows that initially, the error increased slightly, but then it shows a downward trend, and with the increase in the data, the error tends to zero (0.658). The results also show good fit and optimal accuracy of the model in less processing time.
Generalized backward stochastic differential equations with jumps in a general filtration
Authors: Elmansouri Badr , El Otmani Mohamed 
Published: July 2023

Abstract
In this paper, we analyze multidimensional generalized backward stochastic differential equations with jumps in a filtration that supports a Brownian motion and an independent integer-valued random measure.
Under monotonicity and linear growth assumptions on the coefficients, we give the existence and uniqueness of

𝕃
2

{\mathbb{L}^{2}}

-solutions provided that the generators and the terminal condition satisfy some suitable integrability conditions.
Delay BSDEs driven by fractional Brownian motion
Authors: Aidara Sadibou , Sane Ibrahima 
Published: July 2023

Abstract
This paper deals with a class of delay backward stochastic differential equations driven by fractional Brownian motion (with Hurst parameter H greater than

1
2

{\frac{1}{2}}

). In this type of equation, a generator at time t can depend not only on the present but also on the past solutions. We essentially establish existence and uniqueness of a solution in the case of Lipschitz coefficients and non-Lipschitz coefficients. The stochastic integral used throughout the paper is a divergence-type integral.
Improving the accuracy and internal consistency of regression-based clustering of high-dimensional datasets
Authors: Zhang Bo , He Jianghua , Hu Jinxiang , Chalise Prabhakar , Koestler Devin C. 
Published: July 2023

Abstract
Component-wise Sparse Mixture Regression (CSMR) is a recently proposed regression-based clustering method that shows promise in detecting heterogeneous relationships between molecular markers and a continuous phenotype of interest. However, CSMR can yield inconsistent results when applied to high-dimensional molecular data, which we hypothesize is in part due to inherent limitations associated with the feature selection method used in the CSMR algorithm. To assess this hypothesis, we explored whether substituting different regularized regression methods (i.e. Lasso, Elastic Net, Smoothly Clipped Absolute Deviation (SCAD), Minmax Convex Penalty (MCP), and Adaptive-Lasso) within the CSMR framework can improve the clustering accuracy and internal consistency (IC) of CSMR in high-dimensional settings. We calculated the true positive rate (TPR), true negative rate (TNR), IC and clustering accuracy of our proposed modifications, benchmarked against the existing CSMR algorithm, using an extensive set of simulation studies and real biological datasets. Our results demonstrated that substituting Adaptive-Lasso within the existing feature selection method used in CSMR led to significantly improved IC and clustering accuracy, with strong performance even in high-dimensional scenarios. In conclusion, our modifications of the CSMR method resulted in improved clustering performance and may thus serve as viable alternatives for the regression-based clustering of high-dimensional datasets.
HOTAIRM1 knockdown reduces MPP+-induced oxidative stress injury of SH-SY5Y cells by activating the Nrf2/HO-1 pathway
Authors: Dai Hui-Yu , Chang Ming-Xiu , Sun Ling 
Published: July 2023

Abstract

Objective
Parkinson’s disease (PD) is the second most common neurodegenerative disease with complex pathogenesis. Although HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is upregulated in PD, its exact role in HOTAIRM1 is seldom reported. The purpose of this study is to research the effect of HOTAIRM1 on 1-methyl-4-phenylpyridonium (MPP+)-induced cytotoxicity and oxidative stress in SH-SY5Y cells.

Methods
SH-SY5Y cells were treated with MPP+ at various concentrations or time points to induce SH-SY5Y cytotoxicity, so as to determine the optimal MPP+ concentration and time point. HOTAIRM1 expression upon MPP+ treatment was analyzed through qRT-PCR. Next, HOTAIRM1 was downregulated to observe the variance of SH-SY5Y cell viability, apoptosis, oxidative stress-related indexes, and protein levels of the Nrf2/HO-1 pathway. In addition, rescue experiments were carried out to assess the role of Nrf2 silencing in HOTAIRM1 knockdown on MPP+-induced oxidative stress in SH-SY5Y cells.

Results
MPP+ treatment-induced cytotoxicity and upregulated HOTAIRM1 expression in SH-SY5Y cells in a dose- and time-dependent manner. Mechanically, HOTAIRM1 knockdown enhanced cell viability, limited apoptosis, and oxidative stress, therefore protecting SH-SY5Y cells from MPP+-induced SH-SY5Y cytotoxicity. On the other hand, HOTAIRM1 knockdown activated the protein levels of Nrf2 and HO-1. Nrf2 silencing could counteract the neuroprotective effect of HOTAIRM1 knockdown on in vitro PD model.

Conclusion
Our data demonstrated that HOTAIRM1 knockdown could inhibit apoptosis and oxidative stress and activated the Nrf2/HO-1 pathway, therefore exerting neuroprotective effect on the PD cell model.
Esmolol inhibits cognitive impairment and neuronal inflammation in mice with sepsis-induced brain injury
Authors: Li Yanpeng , Ma Junli , Diao Jianjun , Chen Wei , Wang Zhihua 
Published: July 2023

Abstract
Sepsis is a potentially fatal organ failure resulting from a dysregulated host response to infection. It can be a substantial financial burden on families and society due to the high cost of medical care. The study aims to investigate the protective roles of Esmolol in mice with sepsis-induced brain injuries against cognitive dysfunction and neuronal inflammation. Male C57BL/6J mice were intraperitoneally injected with LPS (10 mg/kg, L2630, Sigma) to establish a septic encephalopathy model. Esmolol (15 mg/kg/h, HY-B1392, MedChemExpress) was subcutaneously infused using osmotic mini-pumps for 6 h before LPS injection. Morris water maze and novel object recognition tests evaluated LPS-induced cognitive impairment and behavioral phenotypes. Cytokines and protein expression were assessed using ELISA assay and RT-qPCR. Esmolol treatment potentially improved cognitive impairment in septic mice. Esmolol administration markedly diminished the abnormal hippocampal neuronal structure, and the expression of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α was significantly downregulated in the hippocampal tissue. Esmolol treatment significantly reduced apoptotic TUNEL-positive cells and reversed the related gene expression (BAX and BCL-2). The effects of esmolol on the reactive oxidative species and oxidative stress markedly reduce malondialdehyde MDA content and increase superoxide dismutase and catalase in hippocampal tissues. In addition, esmolol significantly reduced the percentage and density of Iba-1 + microglia in septic mice. Our results demonstrated that esmolol potentially improved cognitive impairment and neuronal inflammation in mice with sepsis-induced brain injury.
Pre-Event Marketing of Trail Running Events: Stories of People, Place and Experience
Authors: Stadler Raphaela 
Published: July 2023

Abstract
The use of storytelling in destination marketing is well explored, but the role of events in this is under researched. The purpose of this paper is to investigate how two different trail running events in Innsbruck, Austria, use elements of storytelling within their communications strategy in the lead-up to the event, and how stories about the two events are interwoven to create a shared meaning around the image of Innsbruck as an alpine-urban destination. Stories on the event websites, social media, local and national media, and in promotional material are thematically analysed to examine the similarities and differences in storytelling approaches. Findings reveal that both events use a combination of three specific elements – people, place and experience – but different strategies when tapping into each other’s story and hence shaping the overall story of the destination. As such, the paper makes theoretical and practical contributions to the event marketing body of knowledge.
Qualifizierung im digitalen Kulturtourismusmarketing – Eine kritische Auseinandersetzung mit den Angeboten von Tourismusorganisationen für den ländlichen Raum
Authors: Schuhbauer Sarah , Hausmann Andrea 
Published: July 2023

Zusammenfassung
Viele Kultureinrichtungen im ländlichen Raum haben mit der Umsetzung von Informations- und Kommunikationstechnologien (IKT) im Tourismusmarketing zu kämpfen. Die Kultureinrichtungen benötigen deshalb Möglichkeiten für die Qualifizierung ihres Personals. Tourismusorganisationen spielen eine wichtige Rolle bei der Bereitstellung entsprechender Angebote. Im Rahmen einer Interviewstudie wurde deshalb untersucht welche Angebote zur Qualifizierung im digitalen Kulturtourismusmarketing von Seiten der Tourismusorganisationen bereits vorliegen und unter welchen Umständen sie von den Kultureinrichtungen im ländlichen Raum genutzt werden. Die Ergebnisse zeigen, dass zwar bereits einige Angebote vorliegen, diese sich jedoch häufig nicht explizit an Kultureinrichtungen richten. Die Kultureinrichtungen machen von selbigen Angeboten oftmals auch noch nicht Gebrauch. Den Tourismusorganisationen wird daher die Etablierung spezifischer Angebote für Kultureinrichtungen und die Etablierung zusätzlicher Austauschformate empfohlen. Des Weiteren sollte eine Sensibilisierung kommunalpolitischer AkteurInnen stattfinden, die Angebote sollten auf verschiedenen Ebenen verbreitet und starke FürsprecherInnen etabliert werden.
Mito y violencia: una aproximación a la novela ecuatoriana Siete lunas y siete serpientes
Authors: Estrada Hevia Tomás 
Published: July 2023

El propósito de este trabajo será el de analizar el sustrato mítico presente en una novela nacida de este contexto, Siete lunas y siete serpientes (1970), del escritor ecuatoriano Demetrio Aguilera-Malta. La importancia que el mito adquiere dentro de esta novela es la que suscita el presente estudio. Los diferentes mitos y creencias populares insertados en la narrativa maltiana no responden a una mera sucesión cumulativa de los mismos sino que son parte fundamental en la significación de toda la obra en su conjunto.
Palabras clave: literatura contemporánea, Ecuador, Demeterio Aguilera-Malta, Siete lunas y siete serpientes, violencia, mitos.
Distinct Morphological and Molecular Profiles of NAFLD and NAFLD-associated HCC Revealed by Immunohistochemistry and MicroRNA Analysis
Authors: Rusu Ioana , Pirlog Radu , Chiroi Paul , Nutu Andreea , Budisan Liviuta , Puia Vlad Radu , Braicu Cornelia , Berindan-Neagoe Ioana , Al Hajjar Nadim 
Published: July 2023

Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is a common hepatic condition that can progress to hepatocellular carcinoma (HCC) in non-cirrhotic livers. To better understand the development of NAFLD-associated HCC, we performed an integrated morphological and molecular analysis to identify new insights that can improve the follow-up of NAFLD patients.
Methods: Our study included a cohort of 14 NAFLD-associated HCC and 41 NAFLD patients. We analyzed clinical parameters, a four-microRNA (miRNA) panel (miR-21-5p, miR-34a-5p, miR-130a-3p, and miR-155-3p) panel and their relationship with p53 and β-catenin expression.
Results: In the study cohort, the NAFLD-associated HCC patients were predominantly male, older, had significantly altered hepatic function, and a higher incidence of hypertension, type 2 diabetes, and dyslipidemia. Morphologically, the NAFLD-HCC group had substantially higher steatosis, ballooning, and fibrosis grades than the NAFLD group. The β-catenin expression was higher in both adjacent non-tumoral liver tissue (ANT) from NAFLD-associated HCC patients and in HCC tissue com-pared with NAFLD samples. The 4 miRNAs panel showed a dysregulated expression profile between NAFLD, ANT and HCC samples.
Conclusions: This study provides important insights regarding the molecular mechanisms underlying HCC progression in NAFLD patients, allowing for the development of better screening strategies for the early detection of NAFLD-associated HCC.
Diet and Gut Inflammation: The Effect of Diet on Inflammatory Markers in Inflammatory Bowel Disease – A Scoping Review
Authors: Sabo Cristina Maria , Simiras Constantin , Ismaiel Abdulrahman , Dumitrascu Dan L. 
Published: July 2023

Background and Aims: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Studies evaluated the effect of several diets on inflammatory markers in IBD patients. Nevertheless, the results have been inconsistent. Therefore, we conducted this review to evaluate the effectiveness of dietary interventions on inflammatory markers in IBD.
Methods: A comprehensive electronic literature search strategy using the PubMed, Embase, and Scopus was conducted in March 2023 and evaluated inflammatory markers included C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fecal calprotectin (FC), as well as disease severity scores. We included full-text articles that met our inclusion and exclusion criteria. To evaluate the included studies, we used the NHLBI quality evaluation tools.
Results: A total of 16 studies were included in our qualitative synthesis. Elemental and polymeric diets showed similar efficacy in reducing Crohn’s disease activity index (CDAI) and CRP levels. On the other hand, most studies evaluating the effects of omega 3 fatty acids reported no significant improvement. Moreover, protein supplementation was not seen to improve ESR or CRP levels. Except for improvements in FC levels with IgG4-guided exclusion diet in CD patients with elevated CDAI levels, restrictive diets were successful in controlling functional abdominal symptoms but did not appear to have an impact on inflammation in most studies. Furthermore, disease severity scores, CRP, ESR, and FC levels did not significantly change when eating a high-fiber, low-refined-carb, low-fat diet.
Conclusions: Diet plays a vital role in managing IBD by impacting the inflammatory response. Among the interventions studied, enteral nutrition showed the most promising results, improving patients‘ inflammatory status. Restrictive diets effectively managed symptoms and clinical remission but had limited impact on inflammatory markers. Supplementing the diet with fatty acids, omega 3, or proteins did not definitively improve patients‘ condition or inflammation.
Kriminalisasi dan Penegakan Hukum Tindak Pidana Korporasi
Authors: Aryani Fajar Dian 
Published: July 2023

Corporate criminalization is an attempt to coerce punishment against a corporation, or a legal entity/company in the economic sense that commits a crime or an allegation that a company/corporation has committed a crime, while in fact, the company (corporation) itself does not feel that it has done anything accursed. The issues explored in this research revolve around the criminalization of corporate crime within the realm of criminal law in Indonesia and the challenges encountered in enforcing the law against corporations as the perpetrators of such crimes. The main aim of this research is to determine and examine the different phases encompassed in the procedure of making corporate crime illegal, as well as to examine the problems faced in law enforcement when dealing with corporations as the culprits. The research methodology employed for this study is normative juridical, which entails conducting a literature review and examining secondary data sources in the field of law. The findings of this research offer a solution that the criminalization of corporate crimes actually runs very slowly compared to the criminalization of other economic crimes. This is also more or less influenced by the ongoing debate over corporate criminal responsibility.Keywords: criminalization, law enforcement, corporate crime AbstrakKriminalisasi korporasi merupakan suatu usaha untuk mengajukan tuntutan pidana terhadap sebuah perusahaan atau korporasi di bidang ekonomi yang diduga melakukan tindak pidana, meskipun korporasi tersebut mungkin tidak mengakui kesalahan atas tuduhan tersebut. Dalam penelitian ini, fokus utamanya adalah mengkaji bagaimana upaya kriminalisasi terhadap tindak pidana korporasi dilakukan dalam konteks hukum pidana di Indonesia serta problematika yang muncul dalam penegakan hukum terhadap korporasi sebagai pelaku kejahatan. Tujuan utama dari penelitian ini adalah memperoleh pemahaman dan menganalisis tahapan proses kriminalisasi tindak pidana korporasi serta masalah-masalah yang terkait dengan penegakan hukum terhadap korporasi tersebut. Dalam penelitian ini, Metode yang digunakan sebagai pendekatan utama adalah metode yuridis normatif. Metode yuridis normatif merupakan jenis penelitian hukum kepustakaan yang dilakukan dengan mempelajari bahan pustaka dan data sekunder yang relevan. Hasil penelitian ini menunjukkan bahwa pengkriminalisasi terhadap tindak pidana korporasi memiliki kecenderungan untuk berlangsung dengan lambat dibandingkan dengan proses kriminalisasi terhadap tindak pidana ekonomi yang lainnya. Kecepatan ini dipengaruhi oleh adanya perdebatan yang belum terselesaikan mengenai tanggung jawab pidana korporasi.Kata Kunci: Kriminalisasi; Penegakan Hukum; Kejahatan Korporasi