bluuebunny/crossref_metadata_2025_split huggingface dataset:
Steric Effects in Ruddlesden–Popper Blue Perovskites for High Quantum Efficiency
Authors: Lee Ilgeum , Allam Omar , Kim Jiweon , Dou Yixuan , Ahn Hyungju , Proppe Andrew , Dong Yitong , Ma Dongxin , Quan Li Na , Sargent Edward H. , Jang Seung Soon , Kim Dong Ha 
Published: March 2023

AbstractRuddlesden–Popper perovskites (RPPs) feature enhanced stability compared to their bulk counterparts and attract attention for potential applications in light‐emitting diodes (LEDs). However, to date, blue‐emitting RPPs rely on halide compositional tuning, resulting in spectral shifts due to halide segregation under photo‐/electrical‐excitation. Here, efficient blue‐emitting materials with single‐halide RPPs using organic spacer engineering are reported. Experimental and computational results show that the (110)‐oriented thin films exhibit larger bandgap and enhanced stability regardless of the choice of spacers, relative to the (100)‐oriented RPPs. The correlation between the lattice structures and optoelectronic properties reveals that this new class of RPPs exhibits sky‐blue emission at 483 nm with a quantum efficiency of ≈62%. Spearman correlation between the steric size of the spacers and the bandgap is estimated to be 92%, showing that the steric effect is crucial influencers. The protocol and strategy established in this study can be exploited to develop blue perovskite LEDs.
Natural Exponential and Three‐Dimensional Chaotic System
Authors: Liu Shiwei , Wang Qiaohua , Liu Chengkang , Sun Yanhua , He Lingsong 
Published: March 2023

AbstractExisting chaotic system exhibits unpredictability and nonrepeatability in a deterministic nonlinear architecture, presented as a combination of definiteness and stochasticity. However, traditional two‐dimensional chaotic systems cannot provide sufficient information in the dynamic motion and usually feature low sensitivity to initial system input, which makes them computationally prohibitive in accurate time series prediction and weak periodic component detection. Here, a natural exponential and three‐dimensional chaotic system with higher sensitivity to initial system input conditions showing astonishing extensibility in time series prediction and image processing is proposed. The chaotic performance evaluated theoretically and experimentally by Poincare mapping, bifurcation diagram, phase space reconstruction, Lyapunov exponent, and correlation dimension provides a new perspective of nonlinear physical modeling and validation. The complexity, robustness, and consistency are studied by recursive and entropy analysis and comparison. The method improves the efficiency of time series prediction, nonlinear dynamics‐related problem solving and expands the potential scope of multi‐dimensional chaotic systems.
A self‐heuristic inquiry: Unpacking the use of “Decolonization” in therapy and mental health care with and for racialized communities
Authors: Sharma Rajni , Kivell Natalie 
Published: March 2023

AbstractAs a registered psychotherapist and art therapist, my clinical training was primarily based on North American clinical approaches influenced by traditional Euro and western‐centric clinical theories of human behavior. I completed my training feeling certain that traditional clinical mental health practices were not an appropriate fit for racialized communities and could have negative implications for their healing and well‐being. As clinicians, it is our moral obligation to support and enhance the quality of life for marginalized groups. We can do this by challenging our values and knowledge that have been defined and influenced by structures (i.e., education, training, etc.) embedded in these colonial teachings. For this paper, I used a heuristic self‐inquiry research method to investigate these concerns. I interviewed other racialized psychotherapists practicing in Turtle Island (currently mostly occupied by the political entities of Canada and the United States) with the aim to learn how and if decolonization can be used in therapy practice. With this research, I (1) identified a gap in care for racialized communities, (2) questioned if or how a decolonizing approach to care should be considered, (3) explored my discomfort with practitioners in the field that claim their position on decolonizing therapy, practice, and approaches, and lastly (4) propose other ways of knowing that can inform new ways of practicing therapy. The results of this research helped to problematize the language and use of decolonizing therapeutic practices while learning about other concepts that may be relevant yet distinct, such as principles of coloniality/decoloniality. Those of us, therapists or researchers, wanting to disrupt the current practice of therapy need to work together, share knowledge, and challenge each other, so that we can transform the way we practice as psychotherapists. This paper is my contribution to this conversation.
Developing an automated skeletal phenotyping pipeline to leverage biobank‐level medical imaging databases
Authors: Cataldo‐Ramirez Chelsea C. , Haddad David , Amenta Nina , Weaver Timothy D. 
Published: March 2023

AbstractObjectivesCollecting skeletal measurements from medical imaging databases remains a tedious task, limiting the research utility of biobank‐level data. Here we present an automated phenotyping pipeline for obtaining skeletal measurements from DXA scans and compare its performance to manually collected measurements.Materials and MethodsA pipeline that extends the Advanced Normalization Tools (ANTs) framework was developed on 341 whole‐body DXA scans of UK Biobank South Asian participants. A set of 10 measurements throughout the skeleton was automatically obtained via this process, and the performance of the method was tested on 20 additional DXA images by calculating percent error and concordance correlation coefficients (CCC) for manual and automated measurements. Stature was then regressed on the automated femoral and tibia lengths and compared to published stature regressions to further assess the reliability of the automated measurements.ResultsBased on percent error and CCC, the performance of the automated measurements falls into three categories: poor (sacral and acetabular breadths), variable (trunk length, upper thoracic breadth, and innominate height), and high (maximum pelvic aperture breadth, bi‐iliac breadth, femoral maximum length, and tibia length). Stature regression plots indicate that the automated measurements reflect realistic body proportions and appear consistent with published data reflecting these relationships in South Asian populations.DiscussionBased on the performance of this pipeline, a subset of measurements can be reliably extracted from DXA scans, greatly expanding the utility of biobank‐level data for biological anthropologists and medical researchers.
APOE and immunity: Research highlights
Authors: Kloske Courtney M. , Barnum Christopher J. , Batista Andre F. , Bradshaw Elizabeth M. , Brickman Adam M. , Bu Guojun , Dennison Jessica , Gearon Mary D. , Goate Alison M. , Haass Christian , Heneka Michael T. , Hu William T. , Huggins Lenique K. L. , Jones Nahdia S. , Koldamova Radosveta , Lemere Cynthia A. , Liddelow Shane A. , Marcora Edoardo , Marsh Samuel E. , Nielsen Henrietta M. , Petersen Kellen K. , Petersen Melissa , Piña‐Escudero Stefanie D. , Qiu Wei Qiao , Quiroz Yakeel T. , Reiman Eric , Sexton Claire , Tansey Malú Gámez , TCW Julia , Teunissen Charlotte E. , Tijms Betty M. , van der Kant Rik , Wallings Rebecca , Weninger Stacie C. , Wharton Whitney , Wilcock Donna M. , Wishard Tyler James , Worley Susan L , Zetterberg Henrik , Carrillo Maria C. 
Published: March 2023

AbstractINTRODUCTIONAt the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias.METHODSThe meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry.RESULTSDuring the 4‐day meeting, presenters illuminated aspects of the cross‐talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]).DISCUSSIONThis manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.
Highly Stable Triangular Single‐Layer 2D Assemblies: Synthesis and Their Stimuli‐Responsive Elastic and Anisotropic Curling
Authors: Hao Yajiao , Yu Lin , Miyazawa Keisuke , Zhang Shengrui , Liu Mo , Yu Zhongqi , Liu Jun , Yu Yang , Li Song , Xu Shujue , Fukuma Takeshi , Xiao‐An Zhang Sean , Li Minjie 
Published: March 2023

AbstractSynthesis of highly stable two‐dimensional single‐layer assemblies (SLAs) is a key challenge in supramolecular science, especially those with long‐range molecular order and well‐defined morphology. Here, thin (thickness <2 nm) triangular AuI‐thiolate SLAs with high thermo‐, solvato‐ and mechano‐ stability have been synthesized via a double‐ligand co‐assembly strategy. Furthermore, the SLAs show assembly‐level elastic and anisotropic deformation responses to external stimuli as a result of the long‐range anisotropic molecular packing, which provides SLAs with new application potentials in bio‐mimic nanomechanics.
Molecular Dipole Engineering of Carbonyl Additives for Efficient and Stable Perovskite Solar Cells
Authors: Jiang Xiaoqing , Zhang Bingqian , Yang Guangyue , Zhou Zhongmin , Guo Xin , Zhang Fengshan , Yu Shitao , Liu Shiwei , Pang Shuping 
Published: March 2023

AbstractCarbonyl functional materials as additives are extensively applied to reduce the defects density of the perovskite film. However, there is still a lack of comprehensive understanding for the effect of carbonyl additives to improve device performance. In this work, we systematically study the effect of carbonyl additive molecules on the passivation of defects in perovskite films. After a comprehensive investigation, the results confirm the importance of molecular dipole in amplifying the passivation effect of additive molecules. The additive with strong molecular dipole possesses the advantages of enhancing the efficiency and stability of perovskite solar cells (PSCs). After optimization, the companion efficiency of PSCs is 23.20 %, and it can maintain long‐term stability under harsh conditions. Additionally, a large‐area solar cell module‐modified DLBA was 20.18 % (14 cm2). This work provides an important reference for the selection and designing of efficient carbonyl additives.
Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy
Authors: Dong Jiajun , Miao Jinmin , Miao Yiming , Qu Zihan , Zhang Sheng , Zhu Peipei , Wiede Florian , Jassim Brenson A. , Bai Yunpeng , Nguyen Quyen , Lin Jianping , Chen Lan , Tiganis Tony , Tao W. Andy , Zhang Zhong‐Yin 
Published: March 2023

AbstractProtein tyrosine phosphatase 1B (PTP1B) and T‐cell protein tyrosine phosphatase (TC‐PTP) play non‐redundant negative regulatory roles in T‐cell activation, tumor antigen presentation, insulin and leptin signaling, and are potential targets for several therapeutic applications. Here, we report the development of a highly potent and selective small molecule degrader DU‐14 for both PTP1B and TC‐PTP. DU‐14 mediated PTP1B and TC‐PTP degradation requires both target protein(s) and VHL E3 ligase engagement and is also ubiquitination‐ and proteasome‐dependent. DU‐14 enhances IFN‐γ induced JAK1/2‐STAT1 pathway activation and promotes MHC‐I expression in tumor cells. DU‐14 also activates CD8+ T‐cells and augments STAT1 and STAT5 phosphorylation. Importantly, DU‐14 induces PTP1B and TC‐PTP degradation in vivo and suppresses MC38 syngeneic tumor growth. The results indicate that DU‐14, as the first PTP1B and TC‐PTP dual degrader, merits further development for treating cancer and other indications.
Muscular superheroes and girly ducks: Gender talk using comics in the classroom
Authors: Wallner Lars , Aman Robert 
Published: March 2023

AbstractThis paper explores how participants in a Swedish secondary school do gender talk with comics. Swedish schools are tasked with working with gender, but this can be a challenge for many teachers, and finding materials to work with gender aspects can be difficult. Meanwhile, literary research on comics has shown them to be a potential tool for problematising gender, but little educational research has investigated the gender discussions that comics can promote. Therefore, using conversation‐analytical methodology, we have documented situated classroom talk through video observations, focusing on the social construction of gender. Five excerpts are shown, where different aspects of gender talk are displayed and discussed. Results indicate that although students deconstruct and criticise gendered binaries in characteristics and behaviour from comics' imagery, this critique remains superficial, revolving around the hypersexualised body imagery of the muscular superhero the Phantom or the outdated femininity of the girly Daisy Duck. Although comics present an opportunity for discussions of norm critique in the classroom, we suggest that more social‐realistic comics, wherein gender roles are more subtle and nuanced, be used for furthering the research on this topic and allowing students more width when it comes to deconstructing gender binaries.
Effect of high‐frequency repetitive transcranial magnetic stimulation over M1 for consciousness recovery after traumatic brain injury
Authors: Shen Longbin , Huang Yixuan , Liao Yujun , Yin Xiaona , Huang Yulin , Ou Jianlin , Ouyang Hui , Chen Zhuoming , Long Jinyi 
Published: March 2023

AbstractBackgroundThe brain area stimulated during repetitive transcranial magnetic stimulation (rTMS) treatment is important in altered states of consciousness. However, the functional contribution of the M1 region during the treatment of high‐frequency rTMS remains unclear.ObjectiveThe aim of this study was to examine the clinical [the Glasgow coma scale (GCS) and the coma recovery scale‐revised (CRS‐R)] and neurophysiological (EEG reactivity and SSEP) responses in vegetative state (VS) patients following traumatic brain injury (TBI) before and after a protocol of high‐frequency rTMS over the M1 region.MethodsNinety‐nine patients in a VS following TBI were recruited so that their clinical and neurophysiological responses could be evaluated in this study. These patients were randomly allocated into three experimental groups: rTMS over the M1 region (test group; n = 33), rTMS over the left dorsolateral prefrontal cortex (DLPFC) (control group; n = 33) and placebo rTMS over the M1 region (placebo group; n = 33). Each rTMS treatment lasted 20 min and was carried out once a day. The duration of this protocol was a month with 20 treatments (5 times per week) occurring with that time.ResultsWe found that the clinical and neurophysiological responses improved after treatment in the test, control, and placebo groups; the improvement was highest in the test group compared to that in the control and placebo groups.ConclusionsOur results demonstrate an effective method of high‐frequency rTMS over the M1 region for consciousness recovery after severe brain injury.
Early arrival did not ensure the early acquisition of intravenous thrombosis for acute ischemic stroke during the COVID‐19 pandemic
Authors: Qiang Huang , Jin‐mei Sun , Yan‐fei Han , Yong‐bo Zhang 
Published: March 2023

AbstractBackgroundIntravenous thrombolysis (IVT) in acute ischemic stroke (AIS) is a time‐dependent treatment with a narrow therapeutic time window, in which the time delay could result from the deadline effect.MethodsOne hospital‐based cohort was recruited to detect the factors contributing to the deadline effect, where patients with the deadline effect were defined as those who were presented with the onset‐to‐door time (ODT) in the first 50%, while the door‐to‐needle time (DNT) was in the last quartile. DNT (in‐hospital delay) was further subdivided into several time intervals [door‐to‐examination time (DET), door‐to‐imaging time (DIT), door‐to‐laboratory time (DLT), and decision‐making time (DMT) of the patients or their proxies.ResultsA total of 186 IVT cases were enrolled, of which 17.2% (32/186) suffered a delay of the deadline effect. The median age was 66 years, and 35.5% were female. Baseline characteristics were similar between the two groups (all p > .05). For the comparisons of the time intervals, DIT (26 versus 15 min, p = .001) was significantly longer in the group with deadline effect, while the differences of DET, DLT, DMT, and ONT did not reach statistical significance (all p > .05). Upon multivariable adjustment in the binary logistic regression model, longer DIT [odds ratio (OR), 1.076; 95% confidence interval (CI), 1.036–1.118; p < .001], and history of coronary heart disease (OR, 3.898; 95%CI, 1.415–10.735; p = .008) were independently associated with deadline effect in the binary logistic regression model, while admitted in the working day (OR, 0.674; 95%CI, 0.096–0.907; p = .033), and having medical insurance (OR, 0.350; 95% CI, 0.132–0.931; p = .035) were negatively associated with the deadline effect.ConclusionsA speed‐safety tradeoff phenomenon from the deadline effect was observed in 17.2% of IVT cases during the COVID‐19 pandemic, where longer DIT contributed a lot to this time delay. Patients without medical insurance, or admitted in official holidays were more likely to experience a delay of the deadline effect.
Long‐term effects of childhood trauma subtypes on adult brain function
Authors: Cai Jianjian , Li Jia , Liu Dong , Gao Sikang , Zhao Yunyun , Zhang Jiaxuan , Liu Qin 
Published: March 2023

AbstractIntroductionChildhood trauma is prevalent in our society, whereas little is known about why and how different forms of early traumatic experiences exert long‐term effects on differential brain function in adulthood.PurposeThis study aimed to scale experience‐specific neural correlates of distinct subtypes of childhood trauma.MethodsWe used resting‐state functional magnetic resonance imaging data from 216 adults with different degrees of childhood trauma. Graph analysis was combined with the Childhood Trauma Questionnaire to inspect the impact of distinct subtypes of childhood trauma on the brain.ResultsWe found that childhood trauma experiences have a detrimental effect on depression and anxiety behavior. On one hand, childhood neglect scores were positively associated with network transmission efficiency of regions involved in cognitive and executive functions, such as temporal lobe, insular cortex, and parahippocampal gyrus. On the other hand, childhood abuse scores were tightly linked to functional reorganizations of regions mediated by immature ego defense system and damaged emotion representation. Specifically, the abuse scores were positively associated with network transmission efficiency of the visual, auditory, linguistic, and motor cortex. Isolated communications in temporal cortex and supplementary motor cortex were related to emotional and physical abuse scores.ConclusionsOur data showed the differential associations of abusive and neglectful experiences with brain function in adulthood. These experience‐specific associations could underpin potentially differential risks of specific forms of psychiatric sequelae in adulthood. More attentions to maltreated children and timely psychological treatment are needed to reduce the incidence of psychosis.
An exploratory study of green‐lean‐six sigma motivators for environmental sustainability: Managerial insights from a developed and developing economy
Authors: Farrukh Amna , Mathrani Sanjay , Sajjad Aymen 
Published: March 2023

AbstractIncreasingly, companies are embracing the green‐lean‐six sigma (GLSS) approach to managing their environmental impacts. Nevertheless, there is a paucity of studies that examined the underlying motivations behind GLSS deployment in manufacturing organizations. Accordingly, this study investigates the GLSS motivators in a developed and developing economy context through multiple case studies in which semi‐structured interviews are conducted with senior corporate managers in the flexible packaging manufacturing industry. Drawing on the natural resource‐based view (NRBV) and institutional theory‐based view (ITBV), our analysis revealed various operational, organizational, and environmental factors as internal motivators and factors related to the state, society, and market as external motivators. To the best of our knowledge, it is one of the early comparative studies investigating the GLSS motivators in both developed and developing economies, which can guide future researchers, practitioners, and policymakers in understanding the salient factors influencing the GLSS adoption for environmental sustainability.
Surfaceome Profiling Identifies Basigin‐Chaperoned Protein Clients
Authors: Vilen Zak , Joeh Eugene , Lee Elizabeth , Huang Mia L. 
Published: March 2023

AbstractThe surface proteome or “surfaceome” is a critical mediator of cellular biology, facilitating cell‐to‐cell interactions and communication with extracellular biomolecules. Constituents of the surfaceome can serve as biomarkers for changing cell states and as targets for pharmacological intervention. While some pathways of cell surface trafficking are well characterized to allow prediction of surface localization, some non‐canonical trafficking mechanisms do not. Basigin (Bsg), a cell surface glycoprotein, has been shown to chaperone protein clients to the cell surface. However, understanding which proteins are served by Bsg is not always straightforward. To accelerate such identification, we applied a surfaceome proximity labeling method that is integrated with quantitative mass spectrometry‐based proteomics to discern changes in the surfaceome of hepatic stellate cells that occur in response to the genetic loss of Bsg. Using this strategy, we observed that the loss of Bsg leads to corresponding reductions in the cell surface expression of monocarboxylate transporters MCT1 and MCT4. We also found that these relationships were unique to Bsg and not found in neuroplastin (Nptn), a related family member. These results establish the utility of the surfaceome proximity labeling method to determine clients of cell surface chaperone proteins.
Electrocoagulation for the Treatment of Metals Machining Plants Effluents: Experimental and Modeling Study
Authors: Kilany Ahmed Y. , Abdel-Aziz Mohamed Helmy , Nosier Shaaban A. , Hussein Mohamed , Sedahmed Gomaa H. 
Published: March 2023

AbstractTreatment of effluents discharged from mechanical machining of copper and copper alloys for removal of cutting oils and toxic copper ions by electrocoagulation was studied using a cell containing two steel electrodes and a built‐in heat transfer facility. Current density, initial pH of the solution, temperature, starting pollutants' concentrations, amount of NaCl supportive electrolyte, and the impact of gas sparging were investigated. Response surface methodology was used to correlate % oil removal, % copper removal, and electrical energy consumption to the affecting variables. The results imply that the cubic model fits well with the experimental results. The electrocoagulation of oil and copper from waste solutions was optimized using the response optimizer. The simultaneous removal of oil and Cu2+ in the same cell could lower the operational and capital expenses of wastewater treatment.