bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isonimesulide and Its Carborane Analogues as Isoform‐Selective COX Inhibitors and Antitumor Agents
Authors: Useini Liridona , Komazec Teodora , Laube Markus , Lönnecke Peter , Schädlich Jonas , Mijatović Sanja , Maksimović‐Ivanić Danijela , Pietzsch Jens , Hey‐Hawkins Evamarie 
Published: May 2023

AbstractNonsteroidal anti‐inflammatory drugs (NSAIDs) are the most widely used therapeutics against pain, fever, and inflammation; additionally, antitumor properties are reported. NSAIDs reduce the synthesis of prostaglandins by inhibiting the cyclooxygenase (COX) isoforms COX‐1 and COX‐2. As nonselective inhibition is associated with off‐target effects, strategies to achieve selectivity for the clinically preferred isoform COX‐2 are of high interest. The modification of NSAIDs using carborane clusters as phenyl mimetics is reported to alter the selectivity profile through size exclusion. Inspired by these findings, isonimesulide and its carborane derivatives are prepared. The biological screening shows that the carborane containing compounds exhibit a stronger antitumor potential compared to nimesulide and isonimesulide. Furthermore, the replacement of the phenyl ring of isonimesulide with a carborane moiety resulted in a shift of the COX activity from nonactive to COX‐active compounds.
Ultrasound‐Responsive Oxygen‐Carrying Pollen for Enhancing Chemo‐Sonodynamic Therapy of Breast Cancer
Authors: Wen Baojie , Huang Danqing , Song Chuanhui , Shan Jingyang , Zhao Yuanjin 
Published: May 2023

AbstractThe tumor‐suppressing efficacy of either chemotherapeutics or gaseous drugs has been confirmed in treating the triple negative breast cancer (TNBC), while the efficacy of single treatment is usually dissatisfactory. Herein, a novel ultrasound responsive natural pollen delivery system is presented to simultaneously load chemotherapeutics and gaseous drugs for synergistic treatment of TNBC. The hollow structure of pollen grains carries oxygen‐enriched perfluorocarbon (PFC), and the porous spinous process structure adsorbs the chemotherapeutic drug doxorubicin (DOX) (PO/D‐PGs). Ultrasound can trigger the oxygen release from PFC and excite DOX, which is not only a chemotherapeutic but also a sonosensitizer, to realize chemo‐sonodynamic therapy. The PO/D‐PGs are demonstrated to effectively enhance oxygen concentration and increase the production of reactive oxygen species in the presence of low‐intensity ultrasound, synergistically enhancing the tumor killing ability. Thus, the synergistic therapy based on ultrasound‐facilitated PO/D‐PGs significantly enhances the antitumor effect in the mouse TNBC model. It is believed that the proposed natural pollen cross‐state microcarrier can be used as an effective strategy to enhance chemo‐sonodynamic therapy for TNBC.
A very mild phenotype in six individuals of a three‐generation family with the novel HRAS variant c.176C > G p.(Ala59Gly): Emergence of a new HRAS‐related RASopathy distinct from Costello syndrome
Authors: Frey Tanja , Ivanovski Ivan , Bahr Angela , Zweier Markus , Laube Julia , Luchsinger Isabelle , Steindl Katharina , Rauch Anita 
Published: May 2023

AbstractCostello syndrome is a clinically recognizable, severe neurodevelopmental disorder caused by heterozygous activating variants in HRAS. The vast majority of affected patients share recurring variants affecting HRAS codons 12 and 13 and a relatively uniform phenotype. Here, we report the unique and attenuated phenotype of six individuals of an extended family affected by the HRAS variant c.176C>T p.(Ala59Gly), which, to our knowledge, has never been reported as a germline variant in patients so far. HRAS Alanine 59 has been previously functionally investigated as an oncogenic hotspot and the p.Ala59Gly substitution was shown to impair intrinsic GTP hydrolysis. All six individuals we report share a phenotype of ectodermal anomalies and mild features suggestive of a RASopathy, reminiscent of patients with Noonan syndrome‐like disorder with loose anagen hair. All six are of normal intelligence, none have a history of failure to thrive or malignancy, and they have no known cardiac or neurologic pathologies. Our report adds to the previous reports of patients with rare variants affecting amino acids located in the SWITCH II/G3 region of HRAS and suggests a consistent, attenuated phenotype distinct from classical Costello syndrome. We propose the definition of a new distinct HRAS‐related RASopathy for patients carrying HRAS variants affecting codons 58, 59, 60.
Distinct eicosanoid patterns in severe recalcitrant nasal polyposis
Authors: Nordström Axel , Jangard Mattias , Svedberg Marie , Ryott Michael , Kumlin Maria 
Published: May 2023

AbstractBackgroundAlthough altered eicosanoid levels are related to disease severity in chronic rhinosinusitis with nasal polyps (CRSwNP), identifying patients prone to recurrent nasal polyps (NPs) is still difficult. We investigated levels of nasally secreted eicosanoids before and after NP surgery in patients with or without NP recurrence (NPR) and explored potential endotypes based on pre‐surgical eicosanoid levels.MethodsLevels of leukotriene (LT) E4, LTB4, prostaglandin (PG) D2, PGE2 and 15(S) hydroxyeicosatetraenoic acid (15[S]‐HETE) were measured in nasal secretions with specific immunoassays at pre‐surgery (n = 38) and 6 and 12 months post‐surgery (n = 35), with NPR identified endoscopically. Pre‐ and post‐surgical levels were compared between patients with and without NPR. Eicosanoid patterns among patients were explored with cluster analysis and evaluated with clinical parameters.ResultsPatients with recurrent NPs had pronounced pre‐surgical levels of nasal 15(S)‐HETE, PGD2 and LTE4. From pre‐surgery to 12 months post‐surgery, NPR was associated with significant decreases of 15(S)‐HETE and PGD2 relative to non‐recurrence, whereas levels of LTE4 decreased at 6 months but increased again at 12 months. Clustering revealed three potential endotypes. Clusters 1 and 3 featured high and low eicosanoid levels, respectively. Cluster 2 had higher levels of LTE4 and PGD2, lower levels of PGE2 and LTB4, and more cases of recurrent NPs and previous NP surgeries.ConclusionElevated nasal LTE4 12 months post‐surgery in NP recurrent subjects suggests that postoperative LTE4 measurements may indicate rapid NP regrowth. A distinct nasal eicosanoid profile may be used for the identification of the most severe recalcitrant patients in need of targeted immunomodulatory therapies.
A BODIPY‐Based 1D Covalent Organic Framework for Photocatalytic Aerobic Oxidation
Authors: Zhao Jianping , Xie Mo , Chen Xu , Jin Ji‐Kang , Zhao Wei , Luo Jie , Ning Guo‐Hong , Liu Junzhi , Li Dan 
Published: May 2023

AbstractCovalent organic frameworks (COFs) as metal‐free photocatalysts have attracted extensive interest. However, the organic transformations photocatalyzed by COFs under mild conditions remain a challenge. Herein, a boron‐dipyrromethene (BODIPY) based 1D COF, namely JNM‐12, was facilely constructed by Schiff‐base condensation reaction. JNM‐12 exhibited strong visible‐light harvesting abilities and suitable photocatalysis energy potentials, enabling the activation of O2 to superoxide anions (O2⋅−) and singlet oxygen (1O2) under visible light irradiation. Benefiting from these properties, JNM‐12 delivered excellent photocatalytic activity in the O2⋅−‐mediated oxidative coupling of amines and 1O2‐engaged aerobic oxidation of enamines. Our work paves a new way for synthesis of COFs as efficient, economical, and green photocatalysts for organic synthesis.
To aggregate or not to aggregate – Is it a matter of the ribosome?
Authors: Iben Sebastian 
Published: May 2023

AbstractNeurodegenerative syndromes present as proteinopathies – does ribosomal infidelity contribute to the protein toxicity that is the driving force for neuronal cell loss? Intracellular and extracellular protein aggregates overwhelm the clearance capacity of cells and tissues. Proteins aggregate when hydrophobic residues are exposed. Hydrophobic residues become exposed when proteins are misfolded. Protein misfolding can originate from translational errors at the ribosome. Indeed, the most error‐prone process in gene expression is translation at the ribosome. Recent evidence indicates that manipulating the ribosomal accuracy impacts on the lifespan of model organisms and a reduced translational accuracy is accompanied by neurodegeneration. The first hit in aging‐associated neurodegenerative disease may be the well‐documented decline of cellular buffering capacity by aging. A second hit that impacts on the quality of protein synthesis could be the driving force for the observed loss of proteostasis in neurodegeneration. This hypothesis provides an explanation for the late onset of most neurodegenerative diseases.
Cellulase mediated stress triggers the mutations of oleaginous yeast Trichosporon cutaneum with super‐large spindle morphology and high lipid accumulation
Authors: Liu Qi , Li Yuanyuan , Hou Weiliang , Zhang Bin , Bao Jie 
Published: May 2023

AbstractAccumulation of intracellular lipid bodies in oleaginous yeast cells is highly restricted by their natural intracellular space. Here we show a cellulase mediated adaptive evolution with ultra‐centrifugation fractionation of oleaginous yeast Trichosporon cutaneum to obtain the favorable cell structure for lipid accumulation. Cellulase was added to the wheat straw hydrolysate during long‐term adaptive evolution for disruption of cell wall integrity of T. cutaneum cells. The cellulase, together with ultracentrifugation force, triggered multiple mutations and transcriptional expression changes of the functional genes associated with cell wall integrity and lipid synthesis metabolism. The fractionated mutant T. cutaneum YY52 demonstrated the heavily weakened cell wall and high lipid accumulation by the super‐large expanded spindle cells (two orders of magnitude greater than the parental). A record‐high lipid production by T. cutaneum YY52 was achieved (55.4 ± 0.5 g L−1 from wheat straw and 58.4 ± 0.1 g L−1 from corn stover). This study not only obtained an oleaginous yeast strain with industrial application potential for lipid production but also provided a new method for generation of mutant cells with high intracellular metabolite accumulation.
De‐Brominating Flame‐Retardant Polystyrene by Utilizing Basic Oxides in Chemical Recycling
Authors: Kolb Tristan , Schedl Andreas , Kerschbaumer Hannes , Niessner Norbert , Schmidt Hans-Werner , Wilhelmus Bianca 
Published: May 2023

AbstractChemical recycling is a method to close the recycling loop for polymers. This is particularly applicable for polystyrene (PS), where the monomer styrene is directly formed by depolymerization and subsequently utilized for the production of new PS. However, some waste sources contain critical additives as legacies, such as brominated flame retardants. There is a profound need to remove these substances from the material, as current thresholds do not allow such additives above certain limits in new products. In this work we present the beneficial use of basic oxides during the thermal depolymerization of a mixture of PS and 1,2,5,6,9,10‐hexabromocyclododecane. It was demonstrated that especially barium oxide and calcium oxide allowed the reduction of bromine up to 96 % in the crude styrene oil.
Shooting for the stars: What are the topics of reviews that affect star ratings?
Authors: Ahmad Shimi Naurin , Richard Marie‐Odile 
Published: May 2023

AbstractThere is evidence that review ratings affect sales; yet little is known about the drivers of the star ratings from the perspective of the customers who have written them. A person who writes a review touches upon many different aspects of the experience. It is intriguing to explore the underlying topics that motivate customers to provide certain star ratings. Although there have been many studies to predict rating, they are mostly data driven. A marketing perspective and a consumer theory driven approach is still in their infancy. This article aims to fill this gap in the literature, and to explore the topics of reviews and their effects in determining the star ratings of a review. Since review rating influences prospective customers, traffic to the site and ultimately sales, examining the topics that make a customer rate a review in a certain manner is theoretically and managerially important.
Well‐Defined Anisotropic Self‐Assembly from Peptoids and Their Biomedical Applications
Authors: Okuno Yota , Iwasaki Yasuhiko 
Published: May 2023

AbstractPeptoids, or poly(N‐substituted glycine)s, hold great promise in biomedical applications because of their biocompatibility, precise synthesis via conventional peptide‐mimicking methods, and readily tunable side chains, which facilitate the control of hydrophobicity and crystallinity. In the past decade, peptoids have been used to create well‐defined self‐assemblies such as vesicles, micelles, sheets, and tubes, which have been scrutinized at the atomic scale using cutting‐edge analytical techniques. This review highlights recent advancements in peptoid synthesis strategies and the development of noteworthy one‐ or two‐dimensional anisotropic self‐assemblies, i. e., nanotubes and nanosheets, exhibiting well‐ordered molecular arrangements. These anisotropic self‐assemblies are formed through the crystallization of peptoid side chains, which can be effortlessly modified via simple synthesis approaches. Moreover, leveraging the protease resistance of peptoids, various biomedical applications are discussed (including phototherapy, enzymatic mimetics, bio‐imaging, and biosensing) that capitalize on the unique properties of anisotropic self‐assembly.
On the Barton Copper‐Catalyzed C3‐Arylation of Indoles using Triarylbismuth bis(trifluoroacetate) Reagents
Authors: Fnaiche Ahmed , Bueno Bianca , McMullin Claire L. , Gagnon Alexandre 
Published: May 2023

AbstractInvited for this month′s cover are the collaborating groups of Prof. Alexandre Gagnon at the Université du Québec à Montréal in Canada, and Dr. Claire McMullin at the University of Bath in the UK. The cover picture represents the “Chasse‐galerie”, a popular French‐Canadian tale published by the author Honoré Beaugrand in 1892, adapted with landmarks from Montréal, London, and Bath. The aryl groups are being transferred from a pentavalent triarylbismuth reagent to the C3 position of an indole via a copper‐catalyzed C–H activation mechanism. Cover designed by Lysanne Arseneau. More information can be found in the Research Article by Claire L. McMullin, Alexandre Gagnon, and co‐workers.
Photoswitchable Rhodamine‐Based Multianalyte Sensors for Metal Ion Detection
Authors: Srivastava Anjali , Grewal Surbhi , Singh Sapna , Rajani  , Venkataramani Sugumar 
Published: May 2023

AbstractWe have developed three azobenzene‐core‐based molecular systems decorated with different numbers of rhodamine units as photoswitchable multianalyte sensors. Exploiting the ring‐opening of the spirolactam part of the rhodamine unit, the resulting fluorescence response, and modulation of it through the photoswitching of azobenzene by light, we utilized them in the detection of multiple metal ions (Fe3+, Fe2+, Sn2+ and Al3+). The binding sites, stoichiometry, binding constants, fluorescent lifetimes and limit of detection (LOD) for each probe have been deduced using appropriate spectroscopic techniques. The limit of detection (LOD) of 5 a, 5 b and 5 c for Fe3+ are found to be 4.2×10−7±7.8×10−9 M, 2.2×10−7±4.6×10−9 M and 1.2×10−7±4.6×10−9 M, respectively. The fluorescence response of the metal‐chelated complex can be manipulated effectively by employing the photoswitching ability of azobenzene that makes them useful as chemosensors for various individual metal ions.
Overview of Chemical Methods to Probe RNA Structure with Radionucleotides
Authors: Gupta Mrityunjay , Garfio Chely M. , Spitale Robert C. 
Published: May 2023

AbstractStructural features of RNA play an important role in its capability to perform various functions in biological systems. To probe structural features, chemical probes are used to conjugate or cleave RNA at solvent‐accessible sites, differentiating between flexible and constrained regions. These conjugates or cleaved products are then detected using reverse transcription (RT), where enzymatic RNA‐dependent DNA primer extension is abruptly halted at the conjugation site or cleavage site. Here, we provide an overview of methods to probe RNA structure in vitro using radioactively labeled DNA primers, which provide a highly sensitive method to visualize RT stop sites with gel electrophoresis. © 2023 Wiley Periodicals LLC.
A novel wideband fractal‐shaped MIMO antenna for brain and skin implantable biomedical applications
Authors: Kangeyan Rajagopal , Karthikeyan Madurakavi 
Published: May 2023

SummaryA novel fractal‐shaped wideband multiple‐input multiple‐output (MIMO) antenna is proposed for brain and skin implantable applications. This antenna works in the 2.4–2.48 GHz band of industrial, scientific, and medical (ISM) standards. The fractal‐shaped wideband MIMO antenna is miniature in size with a footprint of
. Rogers RT/Duroid 6010 high‐dielectric substrate material is used to fabricate the optimized design in order to validate the implantable MIMO antenna structure. The same high‐permittivity substrate material has been used as a superstrate. Experiments were carried out in brain and skin‐mimicking gel at 2.45 GHz in the ISM band. The proposed antenna has a peak gain of −21.3 dBi at 2.45 GHz. High isolation (>20 dB) between two MIMO ports is attained. The proposed antenna achieves a fractional bandwidth of 36.76% and an impedance bandwidth of 1.02 GHz. According to IEEE safety regulations for 1‐ and 10‐g tissues, the computed maximum specific absorption rate (SAR) is safe bound.
Guidelines on the classification of foot ulcers in people with diabetes (IWGDF 2023 update)
Authors: Monteiro‐Soares Matilde , Hamilton Emma J. , Russell David A. , Srisawasdi Gulapar , Boyko Edward J. , Mills Joseph L. , Jeffcoate William , Game Frances 
Published: May 2023

AbstractBackgroundThis publication represents a scheduled update of the 2019 guidelines of the International Working Group of the Diabetic Foot (IWGDF) addressing the use of systems to classify foot ulcers in people with diabetes in routine clinical practice. The guidelines are based on a systematic review of the available literature that identified 28 classifications addressed in 149 articles and, subsequently, expert opinion using the GRADE methodology.MethodsFirst, we have developed a list of classification systems considered as being potentially adequate for use in a clinical setting, through the summary of judgements for diagnostic tests, focussing on the usability, accuracy and reliability of each system to predict ulcer‐related complications as well as use of resources. Second, we have determined, following group debate and consensus, which of them should be used in specific clinical scenarios. Following this process, in a person with diabetes and a foot ulcer we recommend:
for communication among healthcare professionals: to use the SINBAD (Site, Ischaemia, Bacterial infection, Area and Depth) system (first option) or consider using WIfI (Wound, Ischaemia, foot Infection) system (alternative option, when the required equipment and level of expertise is available and it is considered feasible) and in each case the individual variables that compose the systems should be described rather than a total score;
for predicting the outcome of an ulcer in a specific individual: no existing system could be recommended;
for characterising a person with an infected ulcer: the use of the IDSA/IWGDF classification (first option) or consider using the WIfI system (alternative option, when the required equipment and level of expertise is available and it is considered as feasible);
for characterising a person with peripheral artery disease: consider using the WIfI system as a means to stratify healing likelihood and amputation risk;
for the audit of outcome(s) of populations: the use of the SINBAD score.

ConclusionsFor all recommendations made using GRADE, the certainty of evidence was judged, at best, as being low. Nevertheless, based on the rational application of current data this approach allowed the proposal of recommendations, which are likely to have clinical utility.
Diagnosis and treatment of active charcot neuro‐osteoarthropathy in persons with diabetes mellitus: A systematic review
Authors: Raspovic Katherine M. , Schaper Nicolaas C. , Gooday Catherine , Bal Arun , Bem Robert , Chhabra Avneesh , Hastings Mary , Holmes Crystal , Petrova Nina L. , Santini Araujo Maria Gala , Senneville Eric , Wukich Dane K. 
Published: May 2023

AbstractBackgroundThere are uncertainties regarding the diagnostic criteria, optimal treatment methods, interventions, monitoring and determination of remission of Charcot neuro‐osteoarthropathy (CNO) of the foot and ankle in people with diabetes mellitus (DM). The aims of this systematic review are to investigate the evidence for the diagnosis and subsequent treatment, to clarify the objective methods for determining remission and to evaluate the evidence for the prevention of re‐activation in people with CNO, DM and intact skin.MethodsWe performed a systematic review based on clinical questions in the following categories: Diagnosis, Treatment, Identification of Remission and Prevention of Re‐Activation in people with CNO, DM and intact skin. Included controlled studies were assessed for methodological quality and key data from all studies were extracted.ResultsWe identified 37 studies for inclusion in this systematic review. Fourteen retrospective and observational studies relevant to the diagnosis of active CNO with respect to clinical examination, imaging and blood laboratory tests in patients with DM and intact skin were included. We identified 18 studies relevant to the treatment of active CNO. These studies included those focused on offloading (total contact cast, removable/non‐removable knee high devices), medical treatment and surgical treatment in the setting of active CNO. Five observational studies were identified regarding the identification of remission in patients who had been treated for active CNO. We did not identify any studies that met our inclusion criteria for the prevention of re‐activation in patients with DM and intact skin who had been previously treated for active CNO and were in remission.ConclusionsThere is a paucity of high‐quality data on the diagnosis, treatment, and prognosis of active CNO in people with DM and intact skin. Further research is warranted to address the issues surrounding this complex disease.