bluuebunny/crossref_metadata_2025_split huggingface dataset:
¿Cómo se sitúan las escuelas españolas del medio rural ante la innovación? Un estudio exploratorio mediante entrevistas
Authors: Álvarez-Álvarez Carmen , Vejo-Sainz Rocío 
Published: February 2023

RESUMENHoy día las escuelas del medio rural se caracterizan por una gran diversidad en sus orígenes, gestión y proyección. Sin embargo, una característica común es que deben afrontar dos retos: la falta de alumnado y el aislamiento. En este artículo damos respuesta a cómo se sitúan las escuelas del medio rural ante la innovación tras realizar un estudio cualitativo basado en entrevistas en profundidad con informantes clave procedentes de escuelas rurales de cinco comunidades autónomas españolas y tres Centros Rurales de Innovación Educativa. Los resultados muestran que las innovaciones surgen por diferentes vías y se ven influidas por aspectos facilitadores y entorpecedores específicos. Así, logran superar el aislamiento y ofrecer una educación de calidad. Las escuelas rurales entienden la innovación como un reto que les permite superar sus dificultades, y aunque los procesos de cambio presentan retos, logran avanzar y tener un impacto positivo en el medio rural.Palabras Clave: escuela rural, escuelas ubicadas en el medio rural, innovación educativa, entrevistas en profundidad.ABSTRACTNowadays schools in rural areas are characterized by great diversity in their origins, management and projection. However, a common feature is that they face two challenges: the lack of students and the isolation. In this article, we respond how schools located in rural areas face the innovation after accomplished a qualitative study based on in-depth interviews with key informants from rural schools of five different Spanish autonomous communities and three Educational Rural Innovation Centres. The results show that the innovations are arised in different ways and they are influenced by facilitator aspects and specific hinders. Thus, they manage to overcome isolation and provide quality education. Rural schools understand innovation as a challenge that allows them to overcome their difficulties, and although change processes present challenges, they achieve progress and have a positive impact on rural areas.Keywords: rural school, schools in rural areas, educational innovation, in-depth interviews.
An Antipodal Seismic and (Infra)acoustic View from Central Europe on the 15 January 2022 Hunga–Tonga–Hunga–Ha’apai Eruption
Authors: Kraft Toni , Ling On Ki Angel , Toledo Tania , Scheu Bettina , Stähler Simon C. , Clinton John , Stange Stefan 
Published: February 2023

Abstract
We present seismic and (infra)acoustic observations of the 15 January 2022 Hunga–Tonga–Hunga–Ha’apai (HTHH) eruption from Switzerland and central Europe at epicentral distances around 153°. Our observations indicate that the efficient seismoacoustic coupling of locally confined atmospheric oscillations (at the volcanic plume) and long-reaching (global) atmospheric waves at frequencies around 4 mHz is responsible for the global seismic reach of the HTHH eruption at low frequencies. At high frequencies (HFs), we recorded many short impulsive seismoacoustic signals with frequencies well above 20 Hz. They coincided with the passage of the HF part of the rather low-frequency atmospheric wave and triggered numerous false local-earthquake detections on the Swiss monitoring system. Simultaneous reliable ear witness reports of thunderlike sounds from southwest Germany suggest that signals related to the eruption were audible in central Europe at a distance of more than 17,000 km from HTHH. We postulate that the source of these HF seismoacoustic signals was the vigorous volcanic lightning activity observed at HTHH.
Application of Enhanced Recovery after Surgery Pathways in Patients Undergoing Laparoscopic Cholecystectomy With and Without Common Bile Duct Exploration
Authors: Nair Abhijit , Al-Aamri Hamed HM , Borkar Nitin , Rangaiah Manamohan , Haque Parwez W 
Published: February 2023

Many researchers implemented enhanced recovery after surgery (ERAS) pathways for laparoscopic cholecystectomy (LC) and found it effective over conventional care. This review investigates the efficacy and safety of ERAS pathways implemented for LC over conventional practices. We searched PubMed/Medline, SCOPUS, CENTRAL, Ovid, and clinicaltrials.gov using relevant keywords to identify studies in which ERAS pathways in LC were compared with conventional pathways. The primary outcome was length of stay (LOS) from the day of surgery and the secondary outcomes were comparison of pain scores, postoperative nausea/vomiting (PONV), readmissions (within 30-days after surgery), complications (medical and surgical), time to first flatus, and cost. Out of 590 articles identified, 6 studies (n=1489 patients) fulfilled inclusion criteria and were used for qualitative and quantitative analysis. On pooled analysis, the LOS, time to first flatus, PONV, pain scores were significantly less in ERAS group than the conventional one. However, readmission and complications were comparable in both groups.
Keywords: Cholecystectomy; Enhanced recovery After Surgery; Fast-track surgery; Laparoscopy; Meta-analysis; Perioperative care; Systematic review.
Identification of Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections among Healthcare Workers at Sultan Qaboos University Hospital, Oman
Authors: Al Shibli Amal , Al Jufaili Mahmood , Al Alawi Awatif , Balkhair Abdullah , Al Zakwani Ibrahim , Al Azri Faisal , Al Maamari Khuloud , Ba Alawi Fatma , Al Qayoudhi Azza , Al Ghafri Hajar 
Published: February 2023

Objectives: This study aimed to describe the incidence and features of asymptomatic COVID-19 infections among HCWs at a tertiary hospital in Oman. Methods: This cross-sectional study was conducted between August 2020 and February 2021 among HCWs with no history of COVID-19 infection using an online questionnaire to collect sociodemographic and clinical data. COVID-19 infection was diagnosed using nasopharyngeal/throat swabs, which were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Analyses were performed using Chi-squared test, Fisher’s exact test, or univariate ordinary least squares regression, as appropriate. Results: A total of 583 HCWs participated in the study. Most were female (56.6%) and the mean age was 35 ± 8 years . Only 9.6% (95% confidence interval [CI]: 7.3–12.3%) of the HCWs were at high exposure risk as they were directly involved in the care of COVID-19-infected patients. Overall, 4.1% (95% CI: 2.7–6.1%) of the HCWs screened positive for SARS-CoV-2; of these, five (20.8%) developed symptoms within two weeks. The frequency of SARS-CoV-2 positivity among HCWs working in high, intermediate, low, and miscellaneous risk areas was 1.8% (95% CI: <0.1–9.6%), 2.6% (95% CI: <0.1–6.5%), 5.3% (95% CI: 0.3–9.3%), and 4.8% (95% CI: <0.1–69.3%), respectively. Working in high-risk areas was associated with increased compliance with various infection control strategies (P <0.001). Conclusion: There was a greater frequency of SARS-CoV-2 positivity among HCWs working in lower-risk areas, whereas HCWs who worked in high-risk areas were significantly more likely to report increased compliance with infection control strategies.
Keywords: SARS-CoV-2; COVID-19 Nucleic Acid Testing; Asymptomatic Infections; Health Personnel; Occupational Exposure; Infection Control; Real-Time Polymerase Chain Reaction; Oman.
Steppingstones in larger struggles. How can we combine colliding struggles in the care crisis?
Authors: Sebaly Bernadett 
Published: February 2023

The question of whether to increase the caregiver benefit is a controversial one among policy experts and movement actors. It is criticized as counterproductive to the emancipation of disabled people and women. At the same time, it becomes the goal of organizing campaigns as it provides immediate solutions, particularly to low-income families. This spotlights two questions: 1. How can activists fight for large-scale, transformative outcomes and achieve real, tangible changes in people’s lives? 2. How can a constituency fight for its liberation without leaving other constituencies behind? Drawing on the analysis of the Hungarian caregivers’ struggle, I reveal prospects for an emancipatory resolution of these two questions. I suggest seeing the struggles of affected constituencies as different dimensions of the care crisis and propose an organizing framework that engages with the deep structural underpinnings of capitalism and takes the issues of power and control inherent in care relations seriously. Received: 05 July 2022 Approval: 05 December 2022 Published online: Articles in Press, February 2023
In cats undergoing midline ovariohysterectomy, is the use of local anaesthesia with bupivacaine associated with a reduction in postoperative pain score?
Authors: Freeman Tara , Wisbey Amelia , Burroughs Kate , Gentle Samantha , Ellis Connie , Batt-Williams Sarah 
Published: February 2023

PICO question
In cats undergoing midline ovariohysterectomy, is the use of local anaesthesia with bupivacaine via intraperitoneal or subcutaneous injections, in comparison with the use of a control substance or other analgesic measure, associated with a reduction in postoperative pain score?

Clinical bottom line
The category of research question:
Treatment.
The number and type of study designs that were critically appraised:
Three studies were critically appraised in this Knowledge Summary. They included two prospective, blinded, randomised, controlled clinical trials and one prospective randomised, blinded clinical trial.
Strength of evidence:
Weak.
The outcomes reported:
Bupivacaine does not eliminate postoperative pain in cats undergoing ovariohysterectomies; minimal evidence was found to suggest that it was better at reducing postoperative pain scores in comparison to other analgesics. However, bupivacaine may provide analgesic benefits to cats when administered via intraperitoneal or subcutaneous injections as local anaesthesia and in combination with other analgesic agents. The need for postoperative rescue analgesia was minimised when bupivacaine was administered prior to or during the ovariohysterectomy.
Conclusion:
When compared to a control, pain scores for the participating cats were lower after administration of bupivacaine, however, statistical significance was only reached in one of the studies. Additionally, other medications were found to lower the post operative pain score to a greater effect. However, bupivacaine administration is cheap and simple to perform, so it’s use as part of a multimodal analgesic protocol is supported. Confounding factors within the studies may have altered the perceived effectiveness of the analgesic properties of bupivacaine though, so further investigation involving larger cohorts with standardised controls would be prudent.

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Rejuvenasi Peraturan Pengelolaan Prekursor: Ratio Legis dan Efektivitas
Authors: Alfath Tahegga Primananda , Anita Kristy 
Published: February 2023

This legal research aims to examine the legal aspect ratio of legal instruments relating to pharmaceutical precursors as they relate to rejuvenation efforts; while at the same time reviewing based on the perspective of legal effectiveness on the regulation of pharmaceutical precursors. The results of this study state that the ratio of precursors to legislative regulation can be seen from three approaches, namely philosophical, juridical, and sociological. On the philosophical aspect, the 1945 Constitution provides an obligation to the government to provide welfare for matters related to health, the use of pharmaceutical precursors by the public. Then, from a juridical aspect, there are various legal products related to the management and utilization of pharmaceutical precursors; as the legal instruments are interrelated with each other. Sociologically, the illegal production and use of psychotropic substances through precursors will disrupt the economy, security and public health. However, the regulation on precursors has not been implemented in terms of structure, substance, effectiveness or culture; Thus, there are still many deviations in the management of precursors in the community.
KEYWORDS: Rejuvenation, Pharmaceutical Precursors, Law Effectiveness
Upaya Pemenuhan Kebutuhan Lahan Parkir di Stasiun Kereta Api Bojonegoro
Authors: Rodhi Nova Nevila , Putra M Bagas Dwi Permana 
Published: February 2023

Stasiun kereta api Bojonegoro merupakan stasiun terbesar di wilayah Bojonegoro yang melayani banyak keberangkatan dan kedatangan kereta api. Saat ini stasiun kereta api Bojonegoro telah dilengkapi fasilitas yang lumayan lengkap untuk memberikan pelayanan yang baik. Salah satunya adalah ruang parkir pengunjung. Dengan adanya calon penumpang yang semakin meningkat menyebabkan kendaraan di lokasi area parkir semakin padat, bahkan terdapat kendaraan yang parkir di luar ruang parkir yang telah disediakan. Berdasarkan hal tersebut, maka makalah ini membahas terkait evaluasi lahan parkir yang telah tersedia di stasuin kereta api Bojonegoro dengan menggunakan metode deskriptif kuantitatif. Hasil evaluasi menunjukkan bahwa nilai indeks parkir kendaraan roda dua dan roda empat di hari akhir pekan memliki nilai >100% yang artinya ruang parkir untuk sepeda motor dan mobil di hari akhir pekan tidak memenuhi standar. Selain itu evaluasi juga dilihat dari analisis satuan ruang parkir (SRP), dalam hal ini hasilnya menujukkan bahwa pada saat hari akhir pekan kebutuhan SRP lebih banyak, yaitu sebesar 79 kebutuhan SRP sepeda motor, sedangkan SRP sepeda motor yang tersedia berjumlah 50, untuk mobil kebutuhan SRP sebesar 26, sedangkan yang telah tersedia adalah sebesar 16 SRP, sehingga dalam hal ini perlu diadakan penambahan ruang parkir di stasiun kereta api Bojonegoro.
ABSTRACTBojonegoro Railway Station is the largest station among all sub-station in Bojonegoro where every day busy traffic both departure and arriving turn over. Nowadays, Bojonegoro Railway Station is completely equipped with some facilities to support better services. One of the facilities provided is the parking lot for the visitor. The improvement of the users caused the vehicles to load the parking lot. Moreover, some visitors also park their vehicles outside the parking lot. Using descriptive quantitative, this article focused to evaluate the use of the parking lot provided by Bojonegoro Railway Station services. The result of the evaluation showed that the parking index value of vehicles reach more than 100% on weekends. It indicated that the parking area provided for vehicles, especially during the weekend is not able to equip the visitors’ needs or is below the standard. Besides, the evaluation also viewed from SRP analysis (parking space unit) which indicated that during the weekend, the need of SRP (parking space unit) increased to 79 (seventy-nine) spaces for motorcycles while the available space for motorcycles is only 50 (fifty) spaces/units. On the other hand, the space needed for the car reached 26 (twenty-six) units while the availability of the space is only able to cover 16 (sixteen) units. The results indicated the need for the stakeholders to accommodate the improvement of the parking area at Bojonegoro railway station.
Screw Apophysiodesis for Chronic Ischial Apophysitis Refractory to Apophyseal Drilling in a Teenage Athlete
Authors: Zebrack Joshua P. , Kalisvaart Michael , O'Mara Timothy J. 
Published: February 2023

Case:
A 17-year-old elite male soccer player, initially treated for chronic ischial apophysitis with transapophyseal drilling 18 months before, presented with persistent apophysitis symptoms and unfused apophysis on imaging. An open screw apophysiodesis was performed. The patient was able to gradually return to play and, within 8 months, was competing symptom-free at a high-level soccer academy. At 1 year postoperatively, the patient was still playing soccer and continued to be asymptomatic.

Conclusion:
In refractory cases not responding to conservative management or transapophyseal drilling, screw apophysiodesis may be used to obtain apophyseal closure with symptom resolution.
Classification of patients with lithium-treated bipolar disorder based on gene expression: Dirichlet Bayesian network model
Authors: Salari Nader , Shahsavari Soodeh , Almasi Afshin , Pilangorgi Sahar Souri 
Published: February 2023

Abstract
Backgrounds: Dirichlet Bayesian network (DBN) model is a method with score-based structural learning, leading to a more accurate knowledge of the structure of the Bayesian network. Therefore, the DBN was used in this study to classify gene expression data in bipolar disorder (BD) with lithium treatment.
Methods: In this study, gene expression data of patients with BD, including 47323 genes, were used, of which 30 received standard treatment and 30 received lithium treatment. The first essential variables were selected using partial least squares (PLS) regression to analyze and classify the data. The plaid algorithm was used to discover identical patterns and biclusters of gene expression data. We implemented principal component analysis (PCA) to represent a component for each bicluster. Then we created the DBN model toclassify the correlation network. Finally, the accuracy of the prediction model was evaluated using Receiver operating characteristic (ROC) curve analysis. R3.6.2 software was used to analyze the data.
Results: In this analysis, the number of essential and significant genes discovered using PLS regression was 10788. We used the plaid algorithm and nine homogeneous biclusters were discovered. The representative component of the biclusters was selected with at least 75% of the variance in the data using PCA. Then the classification was performed using DBN which the model's accuracy was 0.86 and the model's precision was 0.91.
Conclusions: This study demonstrates the potential of an ensemble approach, which can be developed for network analysis for thousands of genes. Combining models produces more robust and accurate models than single models. Also, network analysis is a desirable approach to detect subtle but coordinated changes in the mutual and related expression of a set of genes. This method can help study other diseases using existing datasets.
Naturally occurring Dinactin targets cpsA of LytR-Cps2A-Psr family protein as well as kills Mycobacterium tuberculosis by disrupting proton motive force
Authors: Tan Chen , wang yan , dong qi , Bai Yajuan , Li Yuxin , feng jia , Ren Xuanxiu , Lu Hao , Lu Weijia , Wang Chenchen , Tang Jia , li pei , wang rui , Chen Huanchun , Wang Xiangru 
Published: February 2023

Abstract
Tuberculosis is still a global threat, and new drugs are desperately needed to combat the spread of multidrug-resistant Mycobacterium tuberculosis. Historically, natural products have been an important source of drugs against infectious diseases, like tuberculosis. Here, we identified a natural macrotetrolide dinactin with antituberculosis activity against susceptible and non-replicating Mycobacterium tuberculosis. Dinactin can synergistically enhance the antituberculosis effect of rifampicin and isoniazide against wild-type and drug-resistant strains. Dinactin also demonstrates antituberculosis activity in macrophage and Galleria mellonella models. Interestingly, dinactin possesses the properties of the ionophore. It not only enhances cations transport across the cell membrane and can alter membrane permeability but also causes the dissipation of proton motive force and metabolic perturbations. By selecting spontaneous resistant mutants and whole genome sequencing, we successfully identified non-synonymous single nucleotide polymorphisms in the cpsA gene of the LytR-Cps2A-Psr family. The dinactin-resistant mutants decrease the in vitro drug sensitivity to dinactin without cross-resistant with first-line antituberculosis drugs. Subsequently, genetic studies and molecular biology assays confirm the cpsA as the principal target. These findings suggest that dinactin could be a promising antibiotic for treating drug-resistant tuberculosis.
Feasibility of an Evolutionary Tumor Board for Generating Novel Personalized Therapeutic Strategies
Authors: Robertson-Tessi Mark , Brown Joel , Poole Maria , Johnson Matthew , Marusyk Andriy , Gallaher Jill , Luddy Kimberly , Whelan Christopher , West Jeffrey , Strobl Maximillian , Turati Virginia , Enderling Heiko , Schell Michael , Tan AikChoon , Boyle Theresa , Makanji Rikesh , Farinhas Joaquim , Soliman Hatem , Lemanne Dawn , Gatenby Robert , Reed Damon , Anderson Alexander , Chung Christine 
Published: February 2023

Abstract
The current paradigm of clinical trials treating patients until disease progression using maximum tolerated dose does not account for the dynamic tumor-host-drug interactions that result in acquired resistance. Here, we present the concept of an Evolutionary Tumor Board (ETB) and report interim results from a prospective, non-interventional pilot study in which novel therapeutic strategies based on evolutionary principles were developed under the ETB framework. The ETB approach relies on an interdisciplinary team that integrates clinical, preclinical, and theoretical knowledge and the application of mathematical modeling to predict patient responses to different therapies, including novel approaches derived from eco-evolutionary first principles. We have previously proposed several evolutionary therapies that aim to enhance the efficacy of an overall treatment regimen, using existing agents for a given disease. Key among these evolutionary therapies is the idea of “first-strike second-strike”, where different agents are administered in sequence, and new strikes are applied as soon as the efficacy of the previous strike is nearing a minimum, as opposed to waiting until progression is identified on periodic imaging. This approach requires careful analysis of longitudinal patient data coupled with predictive dynamics generated by mathematical models. Here we describe the ETB process and the interim results from 15 patients enrolled in the feasibility trial. In addition, we describe the challenges faced as well as the solutions that can be implemented via improved modeling approaches, better patient data collection, and a reassessment of how we understand tumor dynamics in the light of evolutionary principles.