bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preclinical evaluation of sentinel node localization in the stomach via mannose-labelled magnetic nanoparticles and indocyanine green
Authors: Cousins Aidan , Krishnan Shridhar , Krishnan Giri , Pham Nguyen , Milanova Valentina , Nelson Melanie , Shetty Anil , Ikoma Naruhiko , Thierry Benjamin 
Published: May 2023

AbstractBackgroundGastrectomy with extended (D2) lymphadenectomy is considered standard of care for gastric cancer to provide the best possible outcomes and pathologic staging. However, D2 gastrectomy is a technically demanding operation and reported to be associated with increased complications and mortality. Application of sentinel lymph node (SLN) concept in gastric cancer has the potential to reduce patient morbidity; however, SLN techniques are not established for gastrectomy, in part due to lack of practical tracers. An effective and convenient tracer with enhanced SLN accumulation is critically needed.MethodsMannose-labelled magnetic tracer ‘FerroTrace’ and fluorescent dye indocyanine green (ICG) were injected laparoscopically into the stomach submucosa of 8 healthy swine under general anaesthesia. Intraoperative fluorescence imaging was used to highlight draining lymphatic pathways containing ICG, while preoperative T2-weighted MRI and ex vivo magnetometer probe measurements were used to identify nodes containing FerroTrace. Lymphadenectomy was performed either robotically (n= 2) or via laparotomy (n= 6).ResultsMixing ICG and FerroTrace ensured concurrence of fluorescent and magnetic signals in SLNs. An initial trial with robotic dissection removed all magnetic LNs (n= 4). In the subsequent laparotomy study that targeted all ICG-LNs based on intraoperative fluorescence imaging, dissection removed an average of 4.7 ± 1.2 fluorescent, and 2.0 ± 1.3 magnetic LNs per animal. Both MRI and magnetometer detected 100% of SLNs (n= 7). FerroTrace demonstrated high specificity to SLNs, which contained 76 ± 30% of total lymphotropic iron, and 88 ± 20 % of the overall magnetometer signal.ConclusionsThrough utilisation of this dual tracer approach, SLNs were identified via preoperative MRI, visualised intraoperatively with fluorescence imaging, and confirmed with a magnetometer. This combination pairs the sensitivity of ICG with SLN-specific FerroTrace and can be used for reliable SLN detection in gastric cancer, with potential applications in neoadjuvant therapy.Graphical abstract
Historical document image analysis using controlled data for pre-training
Authors: Rahal Najoua , Vögtlin Lars , Ingold Rolf 
Published: May 2023

AbstractUsing neural networks for semantic labeling has become a dominant technique for layout analysis of historical document images. However, to train or fine-tune appropriate models, large labeled datasets are needed. This paper addresses the case when only limited labeled data are available and promotes a novel approach using so-called controlled data to pre-train the networks. Two different strategies are proposed: The first addresses the real labeling task by using artificial data; the second uses real data to pre-train the networks with a pretext task. To assess these strategies, a large set of experiments has been carried out on a text line detection and classification task using different variants of U-Net. The observations, obtained from two different datasets, show that globally the approach reduces the training time while offering similar or better performance. Furthermore, the effect is bigger on lightweight network architectures.
How to conduct variable-density sand tank experiments: practical hints and tips
Authors: Stoeckl L , Houben G 
Published: May 2023

AbstractSand tank experiments are a powerful tool for the investigation and visualization of groundwater flow dynamics. Especially when studying coastal aquifers, where the presence of both fresh and saline water induces complex variable-density flow and transport processes, the controlled laboratory settings of tank experiments help scientists to identify general patterns and features. This technical note provides practical information on planning, conducting and evaluating sand tank experiments, with a focus on application to coastal hydrogeology. Materials, e.g. the sand tank itself, liquids and porous media, are discussed, as well as their handling and auxiliary equipment. The collation of hints and tips is intended to guide novices, as well as experienced researchers, and possibly prevent them from repeating the errors that have been encountered during a long history of experimental work conducted by the authors and researchers associated with many other published studies.
Virtual reality technology using a 360° video: development and evaluation of an educational tool for intraoral radiography using the bisecting angle technique
Authors: Im Ji-Eun , Gu Ja-Young , Lim Eun-Jeong , Lee Jae-Gi 
Published: May 2023

AbstractIntraoral radiography (IOR) practice education is essential for dental students. However, the risk of radiation exposure has resulted in the use of textbooks to learn IOR. Thus, a new educational tool that can effectively use fewer shots or provide indirect experience when practice is not feasible is needed. In this study, we developed a new educational tool called “educational media for the bisecting angle technique” using virtual reality (EMBAT-VR) and evaluated the user experience among students. IOR was divided into 12 steps for 14 teeth, and a scenario was prepared from the perspectives of the operator and patient. On the basis of this scenario, the IOR was reenacted and recorded using a 360° camera. The tool was built on a head-mounted display using the Unity Engine. Eighty-four students were enrolled to evaluate the task performance, browsing search, and satisfaction on a 5-point Likert scale; the corresponding values for the tests were 3. 78 ± 0.70, 3.88 ± 0.76, and 4.01 ± 0.71, respectively. EMBAT-VR was used to investigate the satisfaction (user experience). Responses to 21 questions from 24 students who used traditional textbooks (control group) and 22 students who used the VR educational tool (experimental group) were statistically analyzed using the Mann–Whitney U test. A statistically significant difference was observed between the experimental (4.16 ± 0.64) and control (2.69 ± 0.54) groups. In the usability evaluation, EMBAT-VR presented with a higher score than traditional textbooks. Nonetheless, its effect when performing actual IOR imaging needs follow-up research.
Epidemiology and antimicrobial resistance profile of Neisseria gonorrhoeae in Catalonia, Spain, 2016–2019
Authors: Herrero Mercè , Broner Sonia , Cruells Adrià , Esteve Silvia , Ferré Lourdes , Mendioroz Jacobo , Jané Mireia , Ciruela Pilar ,   the working group at MRSC, Benítez Miguel Ángel , Bosch Jordi , Pitart Cristina , Ballester Frederic , Calderón Ana , Falgueras Teresa , Martí Carmina , Pulido Mª Àngeles , Curriu Margarida , Sanfeliu Ester , Ayala Percy Juan , Gallés Carme , Capdevila Elisenda , Hernández Pilar , Gassiot Paula , Mora Carme , Gómez Frederic , González Araceli , Aixalà Màrius Juanpere , Padilla Eduardo , Gené Amadeu , Navarro Ferran , Rivera Alba , Sánchez Ferran , Trujillo Gloria , López Joan , Olsina Montserrat , Pérez Pepa , Pérez Mar Olga , Ramírez Joan Manel , Raga Xavier , Lucena Judith , Aramburu Jesús , Riera Esther Sanfeliu , Sauca Goretti , Valle Inés , Vilamala Anna , Hoyos Yannick , Cámara Jordi , Niubó Jordi , Rodríguez Graciela , Tubau Fe , Quesada Maria Dolores , Torrellas Nuria , Claver Natàlia , Bastida Teresa , Santos Rosalia , González-Moreno Olga 
Published: May 2023

AbstractAntimicrobial resistance data for Neisseria gonorrhoeae is globally sparse and resistant strains are emerging in Catalonia. We aim to describe epidemiological and antimicrobial resistance in all patients infected with N. gonorrhoeae during the period from 2016 to 2019, using available antimicrobial susceptibility data. We retrospectively analysed confirmed N. gonorrhoeae cases notified to Catalonia’s microbiological reporting system. Antibiotic susceptibility testing (azithromycin, cefixime, ceftriaxone, ciprofloxacin, penicillin, spectinomycin, and tetracycline) was assessed using clinical breakpoints published by the European Committee on Antimicrobial Susceptibility Testing. Incidence rates were calculated and proportions were compared using the χ2 test or Fisher’s exact test, and analysed using the Statistical Package for Social Sciences (SPSS 18.0). A total of 14,251 confirmed cases of N. gonorrhoeae were notified. Incidence increased from 30.7 cases/100,000 person-years (p < 0.001) in 2016 to 64.7 in 2019. Culture was available in 6,292 isolates (44.2%), of which 5,377 (85.5%) were resistant to at least one of the antibiotics tested. Azithromycin resistance rose from 6.1% in 2016 to 16% in 2019 (p < 0.001). Only 1.0% (45 cases) were resistant to ceftriaxone. Multidrug-resistant N. gonorrhoeae increased from 0.25% in 2016 to 0.42% in 2019 (p = 0.521). One case presented extensively drug-resistant N. gonorrhoeae. In Catalonia, 10% of the N. gonorrhoeae isolates were resistant to azithromycin in the 2016–2019 period. According to World Health Organization guidelines, resistance above 5% indicates an alert to review treatment guidelines. Antimicrobial susceptibility testing in clinical practice followed by surveillance and interventions are essential to monitor trends and prevent the spread of antimicrobial resistance.
Hedging and the regret theory of the firm
Authors: Broll Udo , Welzel Peter , Wong Kit Pong 
Published: May 2023

AbstractThis paper examines the production and hedging decisions of the competitive firm under price uncertainty when the firm is not only risk averse but also regret averse. Regret-averse preferences are characterized by a modified utility function that includes disutility from having chosen ex post suboptimal alternatives. The extent of regret depends on the difference between the actual profit and the maximum profit attained by making the optimal production, and hedging decisions had the firm observed the true realization of the random output price. While the separation theorem holds under regret aversion, the prevalence of hedging opportunities may have perverse effect on the firm’s optimal output level, particularly when the firm is sufficiently regret averse. The full-hedging theorem, however, does not hold. We derive sufficient conditions under which the regret-averse firm’s optimal futures position is an under-hedge (over-hedge). We further show that the firm optimally increases (decreases) its futures position when the price risk possesses more positive (negative) skewness.
Adsorption of bovine serum albumin on a mixed-mode resin - influence of salts and the pH value
Authors: Kreusser Jannette , Hasse Hans , Jirasek Fabian 
Published: May 2023

AbstractThe separation and purification of proteins is often carried out by chromatography. Mixed-mode adsorbents are interesting as they may combine favorable features of different chromatographic methods, such as ion-exchange chromatography (IEC) and hydrophobic interaction chromatography (HIC). Systematic experimental studies and models of adsorption isotherms of proteins on mixed-mode resins covering a wide range of parameters are still rare, which hampers both the scientific analysis of the complex processes that occur upon the adsorption of proteins on these resins as well as the practical separation design. Therefore, such studies were carried out in the present work for a model system: the adsorption of bovine serum albumin (BSA) on the mixed-mode resin Toyopearl MX-Trp-650M, which combines features of IEC and HIC resins. Adsorption isotherms were measured using sodium chloride, sodium sulfate, ammonium chloride, and ammonium sulfate at ionic strengths up to 3000 mM and for pH 4.0, 4.7, and 7.0 at 25 $$^\circ$$

∘

C. In the studied pH ranges, BSA exhibits strongly varying net charges and undergoes a conformational change. At pH 4.0 and 4.7, an exponential decay of the BSA adsorption with increasing ionic strength was found at ionic strengths up to approximately 1000 mM, while a rather linear increase was observed at higher ionic strengths for all studied salts; for all salts and ionic strengths, decreasing adsorption with increasing pH value was found. Moreover, a mathematical model was developed, which enables the prediction of equilibrium adsorption isotherms of BSA on Toyopearl MX-Trp-650M for any ionic strength of the studied salts.
Combining Weather Station Data and Short-Term LiDAR Deployment to Estimate Wind Energy Potential with Machine Learning: A Case Study from the Swiss Alps
Authors: Kristianti Fanny , Dujardin Jérôme , Gerber Franziska , Huwald Hendrik , Hoch Sebastian W. , Lehning Michael 
Published: May 2023

AbstractWind energy potential in complex terrain is still poorly understood and difficult to quantify. With Switzerland’s current efforts to shift to renewable energy resources, it is now becoming even more crucial to investigate the hidden potential of wind energy. However, the country’s topography makes the assessment very challenging. We present two measurement campaigns at Lukmanier and Les Diablerets, as representative areas of the complex terrain of the Swiss Alps. A general understanding of local wind flow characteristics is achieved by comparing wind speed measurements from a near-surface ultra-sonic anemometer and from light detection and ranging (LiDAR) measurements further aloft. The measurements show how the terrain modifies synoptic wind for example through katabatic flows and effects of local topography. We use an artificial neural network (ANN) to combine the data from the measurement campaign with wind speed measured by weather stations in the surrounding area of the study sites. The ANN approach is validated against a set of LiDAR measurements which were not used for model calibration and also against wind speed measurements from a 25-meter mast, previously installed at Lukmanier. The statistics of the ANN output obtained from multi-year time series of nearby weather stations match accurately the ones of the mast data. However, for the rather short validation periods from the LiDAR, the ANN has difficulties in predicting lowest wind speeds at both sites, and highest wind speeds at Les Diablerets.
Risk factors associated with left atrial appendage thrombosis in patients with non-valvular atrial fibrillation by transesophageal echocardiography
Authors: Wang Xingpeng , Xu Xiang , Wang Wenting , Huang Haiyun , Liu Feng , Wan Chen , Yao Qing , Li Huakang , Zhang Zhihui , Song Zhiyuan 
Published: May 2023

AbstractPurpose: This study investigated possible mechanism of left atrial appendage (LAA) thrombosis and constructed a model to evaluate the future risk of LAA thrombosis and spontaneous echo contrast (SEC) in non-valvular atrial fibrillation (NVAF) patients. Methods: This retrospective study included 2591 patients diagnosed with NVAF. Patients were divided based on the presence of transesophageal echocardiography (TEE) into a thrombus group, SEC group, and control group. General, biochemical, and echocardiography data of the three groups were analyzed. The variables independently associated with LAA thrombosis and SEC were determined by the logistic regression analysis. A nomogram was constituted based on the regression analysis and the discriminatory ability was analyzed by receiver operating characteristic (ROC) curve. Results: LAA thrombosis and SEC were present in 110 (4.2%) patients and 103 (3.9%) patients, respectively. AF type (OR = 1.857), previous stroke (OR = 1.924), fibrinogen (OR = 1.636), diameters of the left atria (OR = 1.094), left ventricular ejection fraction (OR = 0.938), and LAA maximum caliber (OR = 1.238) resulted as independent risk factors for LAA thrombosis and SEC. The area under curve of the nomogram established by multivariate logistic regression was 0.824. Conclusions; Through the study, 6 independent risk factors related to the LAA thrombosis and SEC were found, and an effective nomogram was constructed to predict the LAA thrombosis and SEC in NVAF patients.
Environmental fluid mechanics of minimum energy loss weirs: hydrodynamics and self-aeration at Chinchilla MEL weir during the November–December 2021 flood event
Authors: Chanson Hubert , Apelt Colin J. 
Published: May 2023

AbstractDuring the recent decades, a number of overflow embankment protection systems were implemented. One design is the Minimum Energy Loss (MEL) weir, developed to pass large flood events with minimum energy loss and low erosion. Several MEL weirs have successfully operated for decades in Australian catchments affected by heavy tropical and sub-tropical rainfalls with very flat gradients. Their historical performances are discussed and confirmed the design capability to pass large floods with small afflux and very small energy loss and little environmental impact including no significant erosion at the abutments. During a major flood, visual and quantitative observations were undertaken at the Chinchilla MEL weir. On the smooth converging chute, the observations showed that the inception of self‐aeration was a three‐dimensional process with a gradual change in free‐surface roughness, from a smooth glassy free-surface to a very-rough choppy surface. An optical technique (OF) was implemented to derive the contour maps of surface velocities based upon video movies taken from a sturdy tripod. The self-aerated flow velocity data were close to the backwater equation in the self‐aerated region, while highlighting regions of high- and low-velocities across the chute. The OF data showed large streamwise surface velocity fluctuations in the aerated flow region, consistent with the broad literature on self-aerated flow measurements. The ratio of transverse to streamwise surface turbulence intensity indicated a strong anisotropy of the free-surface turbulence.
Gambling Harm Experienced by Children Exposed to Parental Gambling: An Online Survey of Australians
Authors: Suomi Aino , Lucas Nina , Dowling Nicki , Delfabbro Paul 
Published: May 2023

AbstractAlthough child wellbeing is known to be negatively affected by gambling, relatively little is known about the specific harms experienced by children exposed to parental gambling problems. The current study aimed to better understand gambling harm directly attributed to regular parental gambling in key areas of child wellbeing: financial, psychological, interpersonal wellbeing and intergenerational transmission of problem gambling. Using data from a national survey of Australian adults exposed to parental gambling under the age of 18 (n = 211), the results show that parental gambling was related significant levels of financial harm, abuse, neglect as well as relational and psychological problems as a direct result of parental gambling. The likelihood of experiencing gambling harms was positively associated with parental problem gambling severity. Harmful impacts of parental gambling as a child were also associated with a range of psychological problems in adulthood including depression, anxiety, Post-Traumatic Stress Disorder and intimate partner violence victimisation. Parental problem gambling severity was negatively associated with own lifetime gambling problems, suggesting a specific pattern of intergenerational transmission of problem gambling in children of regular, or heavy, gamblers. This research highlights the need for more supports for families with children in which at least one parent gambles regularly.
On Magnetic Field Screening and Expulsion in Hydride Superconductors
Authors: Hirsch J. E. , Marsiglio F. 
Published: May 2023

AbstractReference [1] presents evidence for magnetic field screening and “subtle” evidence for magnetic field expulsion in hydrides under high pressure, which is argued to support the claim that these materials are high temperature superconductors. We point out here that data presented in different figures of Ref. [1] are inconsistent (i) with one another, (ii) with other work by the same authors on the same samples [2, 3], and (iii) with the expected behavior of standard superconductors. This suggests that these magnetic phenomena reported for these materials are not associated with superconductivity, undermining the claim that these materials are high temperature superconductors.
An explorative analysis of pharmacovigilance data of oxytocin and its analogue carbetocin, with a focus on haemodynamic adverse effects
Authors: Stämpfli Dominik , Dommrich Rebecca , Orbach-Zinger Sharon , Burden Andrea M. , Heesen Michael 
Published: May 2023

Abstract
Background
Oxytocin and its analogue carbetocin are uterotonics whose prophylactic use is recommended to prevent postpartum haemorrhage, which is one of the leading causes of maternal deaths worldwide. However, both drugs can cause specific adverse effects and haemodynamic challenges.

Aim
The aim of this work was to exploratively examine reports of adverse drug events of both drugs and to establish a comparative haemodynamic profile.

Method
Using data extracted from the World Health Organization’s pharmacovigilance database VigiBase, a descriptive analysis was performed of all reports for oxytocin and carbetocin as a suspected or interacting drug followed by a disproportionality analysis for haemodynamic events. Reporting odds ratios (ROR) of carbetocin for hypertension, hypotension, tachycardia, and bradycardia were calculated, with oxytocin-related reports serving as comparators.

Results
Oxytocin and carbetocin were mentioned as suspected or interacting drugs in 11,258 and 374 reports, respectively. Resulting RORs for carbetocin were 3.45 (95%CI: 1.72–6.92) for hypertension, 2.65 (1.64–4.28) for hypotension, 2.84 (1.79–4.49) for tachycardia, and 2.00 (0.87–4.60) for bradycardia, when compared to oxytocin. Of 231 patients for whom oxytocin-related tachycardia was reported, 2.6% died, and of 91 patients for whom bradycardia was reported, 2.2% died. No deaths were reported with carbetocin for any of the haemodynamic adverse events.

Conclusion
Compared to oxytocin, carbetocin showed an elevated reporting for adverse hypertension, hypotension, and tachycardia in pharmacovigilance data. Clinicians should be aware of their patients' individual susceptibility and the possibility of haemodynamic deterioration until causal inferences are possible.
Bi-functional photocatalytic heterostructures combining titania thin films with carbon quantum dots (C-QDs/TiO2) for effective elimination of water pollutants
Authors: Falara Pinelopi P. , Ibrahim Islam , Zourou Adamantia , Sygellou Labrini , Sanchez David Emanuel , Romanos George Em. , Givalou Lida , Antoniadou Maria , Arfanis Michalis K. , Han Changseok , Terrones Mauricio , Kordatos Konstantinos V. 
Published: May 2023

AbstractIn this study, carbon quantum dots (C-QDs), prepared via hydrothermal-microwave procedures, were successfully combined with nanostructured titania (TiO2). The photocatalytic oxidation/reduction activity of the C-QDs/TiO2 composite films was evaluated in the decomposition of organic-inorganic contaminants from aqueous solutions under UV illumination. Physicochemical characterizations were applied to investigate the crystal structure of the carbon quantum dots and the composites. It was found that the prepared C-QDs/TiO2 composites had great contribution to the photocatalytic reduction of hexavalent chromium (Cr+6) species and 4-Nitrophenol (PNP) as well as to the photocatalytic oxidation of methylene blue (MB) and Rhodamine B (RhB) dyes. The mechanism of the photocatalytic reaction was studied with trapping experiments, revealing that the electron (e−) radical species were powerfully supported for the photocatalytic reduction of Cr+6 and PNP and the holes (h+) are the main active species for the photocatalytic oxidation reactions.