bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of adherence to Mediterranean-like diet pattern with incident rosacea: A prospective cohort study of government employees in China
Authors: Chen Peng , Yang Ziye , Fan Zhihua , Wang Ben , Tang Yan , Xiao Yi , Chen Xiang , Luo Dan , Xiao Shuiyuan , Li Ji , Xie Hongfu , Shen Minxue 
Published: February 2023

BackgroundDespite of growing evidence on gastrointestinal comorbidities of rosacea, there was a lack of literatures regarding the role of diet on rosacea.ObjectivesTo investigate the relationship between adherence to a Mediterranean-like diet pattern and the risk of incident rosacea.MethodsThis was a prospective cohort study of government employees aged &gt;20 years conducted between January 2018 and December 2021 from five cities of Hunan province of China. At baseline, participants completed a food frequency questionnaire and participated in a skin examination. Presence of rosacea was determined by certified dermatologists. Subsequent skin examinations during follow-up were performed every one-year interval since the entry of the study. The Mediterranean diet score (MDS) was generated based on seven food groups (whole grains, red meats, fish, raw vegetables, legumes, fruits and nuts). Binary logistic regression models adjusted for potential confounders were used to estimate risks for incident rosacea.ResultsOf the 3,773 participants who completed at least two consecutive skin examinations, 3,496 were eligible for primary analyses. With a total follow-up of 8,668 person-years, we identified 83 incident rosacea cases. After full adjustments for covariates, the MDS was associated a decreased risk of incident rosacea (aOR: 0.84, 95% CI: 0.72, 0.99; Ptrend = 0.037 for 1-point increment of MDS). In subgroup analyses by body mass index (BMI), this inverse association was consistently observed in the lowest and medium tertiles of BMI (&lt;24.5 kg/m2), but not in the highest tertile of BMI (≥24.5 kg/m2), with a significant interaction effect (P &lt; 0.001).ConclusionsOur results suggested that adherence to a Mediterranean-like diet pattern might reduce the risk of incident rosacea among non-overweight individuals.
Modified anterior approach preserving Retzius space versus standard anterior approach robot-assisted radical prostatectomy: A matched-pair analysis
Authors: Li Hui , Yang Chao , Liao Zhonghong , Wang Kaihong , Zhang Yida , Cao Runfu 
Published: February 2023

ObjectiveTo compare our initial perioperative and postoperative outcomes of the modified anterior approach (MA) with Retzius space preservation robot-assisted radical prostatectomy (RARP) with the standard anterior approach (SA) RARP.Materials and methodsA retrospective analysis was performed on 116 patients with RARP completed by the same surgeon between September 2019 and March 2022. They were divided into SA-RARP group (77 cases) and MA-RARP group (39 cases). Propensity score matching was performed using eight preoperative variables, including age, BMI, preoperative PSA, biopsy Gleason score, prostate volume, D’Amico risk classification, SHIM, and clinical T stage. Functional outcome was assessed by urine pad count and SHIM after surgery, and oncological outcome was assessed by statistics of postoperative pathological findings as well as follow-up postoperative PSA. The median follow-up was 13 months and 17 months for MA-RARP and SA-RARP groups respectively.ResultsPropensity score matching was performed 1:1, and baseline data were comparable between the two groups after matching. Comparison of postoperative data: MA-RARP group had less mean EBL than SA-RARP group (200 vs 150 ml, p = 0.033). PSM did not differ between groups (p = 1). In terms of urinary control recovery, the MA-RARP group showed significant advantages in urinary control recovery at 24 h, 2 weeks, 1 month and 3 months after catheter removal, respectively (48.6% vs 5.7%, p &lt; 0.001; 80% vs 22.9%, p &lt; 0.001; 94.3% vs 51.4%, p &lt; 0.001; 100% vs 74.3%, p = 0.002). This advantage gradually disappeared 6 months or more after surgery. The median time to recovery of sexual function was shorter in the MA-RARP group (165 vs 255 d, p = 0.001).ConclusionMA-RARP is safe and reliable, and can achieve better early urinary control function and sexual function recovery while achieving the primary tumor control goal.
Evaluation of changes of cardiac morphology and function in fetuses with ductus arteriosus constriction by Speckle-tracking echocardiography
Authors: Li Tianjing , Han Jiancheng , Han Yanli , Liu Xiaowei , Gu Xiaoyan , Zhang Ye , Sun Lin , Zhao Ying , Gao Shuang , Hao Xiuxiu , He Yihua 
Published: February 2023

BackgroundPremature ductus arteriosus constriction (DA Con) can result in right ventricular enlargement, right ventricular hypertrophy, and tricuspid regurgitation.MethodThis study retrospectively analyzed 34 singleton fetuses that underwent fetal echocardiography with a diagnosis of DA Con (16 cases with mild to moderate, and 18 cases with moderate to severe) and 45 healthy fetuses. The morphology and function parameters of cardiac, as well as the 24-Segment of ventricles, were compared between the DA Con group and controls, and between the mild to moderate and moderate to severe groups, using the fetal heart quantification (FHQ) technology.ResultsThere were no significant difference in left ventricular parameters in DA Con group when compared to controls. Moreover, fetal 4CV-GSI was significantly reduced, as well as the sphericity index (SI), fractional shortening (FS), global longitudinal strain (GS) and fractional area change (FAC) of right ventricle, especially in the basal-middle segments. Compared with the mild to moderate group, LV-FS increased and RV-FS decreased in moderate to severe group.ConclusionThe results showed that the fetal heart in the DA Con group was different from the controls in morphology and function. FHQ technology provides a comprehensive assessment for the evaluation of cardiac morphological and functional changes in DA Con fetuses.
Delivery and neonatal outcomes of pregnant women during the Shanghai lockdown: A retrospective analysis
Authors: Zhou Fang-Yue , Li Cheng , Qin Kai-Zhou , Luo Chuan , Huang He-Feng , Wu Yan-Ting 
Published: February 2023

ObjectivesShanghai witnessed an unprecedented outbreak of COVID-19 and experienced a strict lockdown from March 28, 2022 to May 31, 2022. Most studies to date are on the first lockdown after the outbreak in December 2019. This study aimed to examine the impact of lockdown on delivery and neonatal outcomes among uninfected pregnant women in the new phase of the COVID-19 outbreak.MethodsA retrospective analysis was conducted in the Obstetrics and Gynecology Hospital of Fudan University. Pregnant women without COVID-19 who delivered from March 28, 2022 to May 31, 2022 (lockdown group) and the same period in 2021 (non-lockdown group) were recruited for this study. Logistic regression models and 1 : 1 propensity score matching (PSM) were used to assess the effect of lockdown on delivery outcomes.ResultsA total of 2,962 patients were included in this study, 1,339 of whom were from the lockdown group. Compared with the non-lockdown group, pregnant women giving birth during lockdown had an increased risk of term prelabor rupture of membranes (TPROM) (aOR = 1.253, 95% CI: 1.026–1.530), and decreased risks of postpartum hemorrhage (PPH) (aOR = 0.362, 95% CI: 0.216–0.606) and fetal malformation (aOR = 0.309, 95% CI: 0.164–0.582). The risk of large for gestational age (LGA) (aOR = 0.802, 95% CI: 0.648–0.992) and rate of admission to the neonatal intensive care unit (NICU) (aOR = 0.722, 95% CI: 0.589–0.885) also significantly declined. After 1 : 1 PSM, the impact of lockdown on the risk of TPROM (aOR = 1.501, 95% CI: 1.083–2.080), PPH (aOR = 0.371, 95% CI: 0.211–0.654), fetal malformation (aOR = 0.332, 95% CI: 0.161–0.684), LGA (aOR = 0.749, 95% CI: 0.594–0.945) and rate of admission to the NICU (aOR = 0.700, 95% CI: 0.564–0.869) all remained. There were no other delivery or neonatal outcomes affected by the lockdown after the COVID-19 outbreak.ConclusionThis study indicated a significant increase in the risk of term PROM, significant decreases in the risk of PPH, fetal malformation and LGA, and a marked decline in the rate of admission to the NICU during Shanghai Lockdown.
Corneal wound healing and nerve regeneration by novel ophthalmic formulations based on cross-linked sodium hyaluronate, taurine, vitamin B6, and vitamin B12
Authors: Bucolo Claudio , Maugeri Grazia , Giunta Salvatore , D’Agata Velia , Drago Filippo , Romano Giovanni Luca 
Published: February 2023

Introduction: To evaluate the pharmacological profile of ocular formulations based on cross-linked sodium hyaluronate (CL-SH), taurine (Tau), vitamin B6 (Vit B6) and vitamin B12 (Vit B12) using in vitro and in vivo paradigms.Methods: Rabbit corneal epithelial cells were used to assess wound healing and reactive oxygen species (ROS) formation by scratch assay and oxidative stress (0.3 mM H2O2; 30 min), respectively with or without ocular formulations exposure. In vivo studies were carried out on albino rabbits to evaluate corneal nerve regeneration and corneal wound healing with or without treatment with six different formulations. Animals were anesthetized, the corneal epithelium was removed, and formulations were topically administered (30 μL/eye; 3 times/day for 6 days). Slit-lamp observation was carried out at different time points. After 6 days the animals were killed, and corneas were collected to evaluate corneal re-innervation by immunohistochemistry of selective neuronal marker β-III tubulin.Results: Formulations containing the concentrations 0.16% or 0.32% of cross-linked sodium hyaluronate, taurine, vitamin B6 and vitamin B12 accelerated corneal wound healing. Cells exposed to H2O2 led to significant (p &lt; 0.05) increase of reactive oxygen species concentration that was significantly (p &lt; 0.05) counteract by formulations containing cross-linked sodium hyaluronate (0.32%) and taurine with or without vitamins. The extent of re-innervation, in terms of β-III tubulin staining, was 5-fold greater (p &lt; 0.01) in the eye of rabbits treated with formulation containing 0.32% cross-linked sodium hyaluronate, taurine, vitamins (RenerviX®) compared with the control group (no treatment). Furthermore, re-innervation elicited by RenerviX® was significantly greater (p &lt; 0.01) compared with the group treated with the formulation containing 0.32% cross-linked sodium hyaluronate and taurine without vitamins, and with the group treated with the formulation containing 0.5% linear sodium hyaluronate (SH), taurine, and vitamin B12, respectively.Discussion: In conclusion, among the formulations tested, the new ophthalmic gel RenerviX® was able to contrast oxidative stress, to accelerate corneal re-epithelization and to promote nerve regeneration.
Impact of polymorphisms in CYP and UGT enzymes and ABC and SLCO1B1 transporters on the pharmacokinetics and safety of desvenlafaxine
Authors: Calleja Sofía , Zubiaur Pablo , Ochoa Dolores , Villapalos-García Gonzalo , Mejia-Abril Gina , Soria-Chacartegui Paula , Navares-Gómez Marcos , de Miguel Alejandro , Román Manuel , Martín-Vílchez Samuel , Abad-Santos Francisco 
Published: February 2023

Venlafaxine pharmacokinetic variability and pharmacotherapy outcomes are well known to be related to CYP2D6 pharmacogenetic phenotype. In contrast, scarce pharmacogenetic information is available nowadays concerning desvenlafaxine, its active metabolite first marketed in 2012. The aim of this study was to evaluate the impact of 29 alleles in 12 candidate genes (e.g., CYP enzymes like CYP2D6, CYP3A4, or CYP2C19; ABC transporters like ABCB1; SLCO1B1; and UGT enzymes like UGT1A1) on desvenlafaxine pharmacokinetic variability and tolerability. Pharmacokinetic parameters and adverse drug reaction (ADR) incidence obtained from six bioequivalence clinical trials (n = 98) evaluating desvenlafaxine formulations (five with single dose administration and one with multiple-dose administration) were analyzed. No genetic polymorphism was related to pharmacokinetic variability or ADR incidence. Volunteers enrolled in the multiple-dose clinical trial also showed a higher incidence of ADRs, e.g., xerostomia or appetite disorders. Volunteers experiencing any ADR showed a significantly higher area under the time-concentration curve (AUC) than those not experiencing any ADR (5115.35 vs. 4279.04 ng*h/mL, respectively, p = 0.034). In conclusion, the strong dose-dependent relationship with the occurrence of ADRs confirms that the mechanism of action of desvenlafaxine is essentially dose-dependent.
Device-evaluated autonomic nervous function for predicting ventricular arrhythmias and all-cause mortality in patients who underwent cardiac resynchronization therapy-defibrillator
Authors: Cheng Chendi , Jiang Jiang , Chen Keping , Hua Wei , Su Yangang , Xu Wei , Fan Xiaohan , Dai Yan , Zhang Shu 
Published: February 2023

Introduction: Autonomic nervous system (ANS) function quantified by heart rate variability (HRV) was associated with long-term prognosis, but it was rarely used in the evaluation of patients with heart failure, especially those with cardiac resynchronization therapy-defibrillator (CRT-D) implantation. This study aimed to describe the changes in ANS function among patients who underwent CRT-D with remote home monitoring function, and explore predictive value of HRV for ventricular tachyarrhythmias (VTAs) and all-cause mortality.Method: Patients who underwent CRT-D implantation were included. Device-measured all-day HR, night-time HR, and HRV (measured by the standard deviation of the atrial–atrial sensed intervals) were used to quantify ANS function. Multivariate Cox proportional hazards models were fitted to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of VTAs or all-cause mortality in relation to ANS function at baseline and 6 months post-implantation. The cutoff value was determined using restrictive cubic splines. Multivariable logistic regression was further established to determine factors influencing postoperative HRV.Results: A total of 170 patients treated with CRT-D were eligible for analysis. During a median follow-up period of 50.8 months, 61 patients died and 69 patients experienced at least one spontaneous episode of VTAs. At 6 months after CRT implantation, 114 patients showed improvement in HRV, increasing from 66.4 ± 19.4 ms to 76.7 ± 21.2 ms. The postoperative HRV was associated with both all-cause mortality (HRs: 0.983; 95% CI: 0.968 to 0.998, p = 0.012) and VTAs (HRs: 0.973; 95% CI: 0.954 to 0.993, p = 0.008), and the relative risk would significantly increase when the postoperative HRV lower than 75 ms. After adjusting for basic ANS function and possible influencing factors, patients without diabetes (p = 0.018) and with higher daily physical activity (p = 0.041) could maintain higher postoperative HRV after CRT implantation.Conclusion: More than two-thirds of heart failure patients showed improvement in ANS function following CRT treatment. However, patients with diabetes and low daily physical activity levels have difficulty maintaining a higher postoperative HRV, which is associated with a worse clinical outcome.
Assessing risk from invasive alien plants in China: Reconstructing invasion history and estimating distribution patterns of Lolium temulentum and Aegilops tauschii
Authors: Yang Ming , Zhao Haoxiang , Xian Xiaoqing , Wang Rui , Yang Nianwan , Chen Li , Liu Wan-xue 
Published: February 2023

IntroductionThe establishment of invasive alien plants (IAPs) is primarily driven by climate warming and human activities, and their populations have a negative impact on agricultural economics, ecological systems, and human health.Lolium temulentumandAegilops tauschiiare critical IAPs in China because they reduce the quality of cereal grains and decrease wheat yields.Lolium temulentumis a winter-temperate weed that spreads easily and is poisonous to humans and animals.Aegilops tauschiiis resistant to herbicides, has a high reproductive rate, and frequently grows in wheat. Both species have been listed in the Ministry of Agriculture and Rural Affairs of the People’s Republic of China’s management catalog since 2006.MethodsIn the present study, the historical occurrence and invasion of each species were collected and reconstructed, which showed that the population outbreak ofL. temulentumbegan in 2010, whereas that ofA. tauschiibegan in 2000. Using the optimal MaxEnt model, the geographical distributions ofL. temulentumandA. tauschiiwere predicted based on screened species occurrences and environmental variables under the current and three future scenarios in the 2030s and 2050s (i.e., SSP1-2.6, SSP2-4.5, and SSP5-8.5).ResultsThe mean AUC values were 0.867 and 0.931 forL. temulentumandA. tauschii, respectively. Human influence index (HII), mean temperature of coldest quarter (bio11), and precipitation of coldest quarter (bio19) were the most significant variables forL. temulentum, whereas human influence index, temperature seasonality (standard deviation×100) (bio4), and annual mean temperature (bio1) were the critical environmental variables forA. tauschi.Suitable habitat areas in China forL. temulentumandA. tauschiicurrently covered total areas of 125 × 104and 235 × 104km2, respectively. Future suitable areas ofL. temulentumreached the maximum under SSP2-4.5, from 2021 to 2060, whereas forA. tauschiithey reached the maximum under SSP5-8.5, from 2021 to 2060. Furthermore, the overlap area under the current climate conditions forL. temulentumandA. tauschiiwas approximately 90 × 104km2, mainly located in Hubei, Anhui, Jiangsu, Shandong, Henan, Shaanxi, Shanxi, and Hebei. The overlap areas decreased in the 2030s, increased in the 2050s, and reached a maximum under SSP1-2.6 (or SSP2-4.5) with an approximate area of 104 × 104km2. The centroid ofL. temulentumin Henan was transferred to the southwest, whereas forA. tauschiiit transferred to higher latitudes in the northeast.DiscussionOur findings provide a practical reference for the early warning, control, and management of these two destructive IAP populations in China.
Metacognitive sensitivity and symptoms of mental disorder: A systematic review and meta-analysis
Authors: Hohendorf Marianne , Bauer Markus 
Published: February 2023

IntroductionMetacognition is a term used to refer to cognition about cognitive processes. In this systematic review and meta-analysis, we reviewed studies that investigated the relationship between experimentally measured objective metacognitive sensitivity and diverse symptoms of mental disorder. In these studies, metacognitive sensitivity is operationalized as the correspondence between the accuracy of task performance and reported confidence therein.MethodsA literature search was conducted across four databases and studies were selected for review based on predefined eligibility criteria. Twenty studies were included in the review and separate meta-analyses were conducted for psychotic and non-psychotic categories of psychiatric symptoms.ResultsA significant reduction (medium effect size) in metacognitive sensitivity was found in individuals with psychosis-related symptoms of mental disorder compared to healthy control groups, but no significant difference was found for individuals with non-psychotic symptoms. It should be noted though, that fewer studies were available for the latter group. Sub-group analysis found no evidence that the effect of metacognitive impairment depended on whether perceptual or non-perceptual experimental tasks were employed.DiscussionThese findings are discussed in relation to other conceptualizations of metacognition and the role reduced metacognitive sensitivity may play in forms of mental disorder.
Brain network changes in adult victims of violence
Authors: Shymanskaya Aliaksandra , Kohn Nils , Habel Ute , Wagels Lisa 
Published: February 2023

IntroductionStressful experiences such as violence can affect mental health severely. The effects are associated with changes in structural and functional brain networks. The current study aimed to investigate brain network changes in four large-scale brain networks, the default mode network, the salience network, the fronto-parietal network, and the dorsal attention network in self-identified victims of violence and controls who did not identify themselves as victims.Materials and methodsThe control group (n = 32) was matched to the victim group (n = 32) by age, gender, and primary psychiatric disorder. Sparse inverse covariance maps were derived from functional resting-state measurements and from T1 weighted structural data for both groups.ResultsOur data underlined that mostly the salience network was affected in the sample of self-identified victims. In self-identified victims with a current psychiatric diagnosis, the dorsal attention network was mostly affected underlining the potential role of psychopathological alterations on attention-related processes.ConclusionThe results showed that individuals who identify themselves as victim demonstrated significant differences in all considered networks, both within- and between-network.
Development and validation of a nomogram to predict cancer-specific survival with unresected cholangiocarcinoma undergoing external radiotherapy
Authors: Song Jiazhao , Di Yupeng , Kang Xiaoli , Ren Gang , Wang Yingjie 
Published: February 2023

ObjectiveTo analyze the prognostic factors of patients with cholangiocarcinoma (CCA) who were unresected and received radiotherapy to establish a nomogram model for the prediction of patient cancer-specific survival (CSS).MethodsSuitable patient cases were selected from the Surveillance, Epidemiology, and End Results (SEER) database, survival rates were calculated using the Kaplan-Meier method, prognostic factors were analyzed by Lasso, Cox regression, and nomogram was developed based on independent prognostic factors to predict 6 and 12 months CSS. The consistency index (C-index), calibration curve, and decision curve analysis (DCA) were tested for the predictive efficacy of the model, respectively.ResultsThe primary site, tumor size, T-stage, M-stage, and chemotherapy (P &lt; 0.05) were identified as independent risk factors after Cox and Lasso regression analysis. Patients in training cohort had a 6 months CSS rates was 68.6 ± 2.6%, a 12-month CSS rates was 49.0 ± 2.8%. The median CSS time of 12.00 months (95% CI: 10.17–13.83 months). The C-index was 0.664 ± 0.039 for the training cohort and 0.645 ± 0.042 for the validation cohort. The nomogram predicted CSS and demonstrated satisfactory and consistent predictive performance in 6 (73.4 vs. 64.9%) and 12 months (72.2 vs. 64.9%), respectively. The external validation calibration plot is shown AUC for 6- and 12-month compared with AJCC stage was (71.2 vs. 63.0%) and (65.9 vs. 59.8%). Meanwhile, the calibration plot of the nomogram for the probability of CSS at 6 and 12 months indicates that the actual and nomogram predict that the CSS remains largely consistent. DCA showed that using a nomogram to predict CSS results in better clinical decisions compared to the AJCC staging system.ConclusionA nomogram model based on clinical prognostic characteristics can be used to provide CSS prediction reference for patients with CCA who have not undergone surgery but have received radiotherapy.