bluuebunny/crossref_metadata_2025_split huggingface dataset:
A longitudinal analysis of involuntary job loss and communication resilience processes during the COVID-19 pandemic
Authors: Kuang Kai , Wilson Steven R , Betts Timothy , Boumis Josephine K , Hintz Elizabeth A , DeBeck Dennis , Buzzanell Patrice M 
Published: February 2023

Abstract
This longitudinal study explored associations between communication resilience processes, job-search self-efficacy, and well-being for a sample of US adults who involuntarily lost their jobs during the second wave of the COVID-19 pandemic. Based on the communication theory of resilience (CTR), we tested four possible models regarding how the enactment of resilience processes would be associated with job-search self-efficacy and well-being over time. Participants (N = 595) described their job loss story and completed measures of communication resilience processes, job-search self-efficacy, and well-being (perceived stress, mental health, and life satisfaction) in February 2021, then completed measures again 2 and 4 months later. Findings from random intercept cross-lagged panel analyses suggested that after accounting for between-person associations, resilience enactment shared significant within-person reciprocal relationships with job-search self-efficacy, perceived stress, and mental health over time. Theoretical implications for CTR, future directions for communication research, and practical implications for supporting diverse job seekers are discussed.
Tibiofemoral dislocation after total knee arthroplasty treated successfully with an external fixation device
Authors: Galanis Athanasios , Papagrigorakis Eftychios , Vavourakis Michail , Karampinas Panagiotis , Vlachos Christos , Patilas Christos , Pneumaticos Spiros , Vlamis John 
Published: February 2023

AbstractTibiofemoral dislocation after primary total knee arthroplasty (TKA) is a rare but potentially devastating complication with various patient-related and surgeon-related predisposing factors. We present the case of an obese 86-year-old woman who sustained an atraumatic posterior tibiofemoral dislocation 3 days after a primary medial-pivot design TKA. The knee remained unstable after reduction, owing to significant hamstring hypertonia. The administration of botulinum toxin injections in the hamstrings resulted in no clinical improvement. The periprosthetic infection workup was negative and the neurological impairment of the patient was excluded. The patient was reoperated with extensive hamstring release and the application of a lateral external fixator. The external fixator was removed 6 weeks postoperatively, and physical therapy was initiated. At 1-year follow-up, the patient had a painless, stable knee with a 0–100° range of motion, without any neuromuscular impairment.
The Interplay Between Developmental Stage and Environment Underlies the Adaptive Effect of a Natural Transposable Element Insertion
Authors: Merenciano Miriam , González Josefa 
Published: February 2023

AbstractEstablishing causal links between adaptive mutations and ecologically relevant phenotypes is key to understanding the process of adaptation, which is a central goal in evolutionary biology with applications for conservation, medicine, and agriculture. Yet despite recent progress, the number of identified causal adaptive mutations remains limited. Linking genetic variation to fitness-related effects is complicated by gene-by-gene and gene-by-environment interactions, among other processes. Transposable elements, which are often ignored in the quest for the genetic basis of adaptive evolution, are a genome-wide source of regulatory elements across organisms that can potentially result in adaptive phenotypes. In this work, we combine gene expression, in vivo reporter assays, CRISPR/Cas9 genome editing, and survival experiments to characterize in detail the molecular and phenotypic consequences of a natural Drosophila melanogaster transposable element insertion: the roo solo-LTR FBti0019985. This transposable element provides an alternative promoter to the transcription factor Lime, involved in cold- and immune-stress responses. We found that the effect of FBti0019985 on Lime expression depends on the interplay between the developmental stage and environmental condition. We further establish a causal link between the presence of FBti0019985 and increased survival to cold- and immune-stress. Our results exemplify how several developmental stages and environmental conditions need to be considered to characterize the molecular and functional effects of a genetic variant, and add to the growing body of evidence that transposable elements can induce complex mutations with ecologically relevant effects.
Speciation Underpinned by Unexpected Molecular Diversity in the Mycorrhizal Fungal GenusPisolithus
Authors: Plett Jonathan M , Miyauchi Shingo , Morin Emmanuelle , Plett Krista , Wong-Bajracharya Johanna , de Freitas Pereira Maira , Kuo Alan , Henrissat Bernard , Drula Elodie , Wojtalewicz Dominika , Riley Robert , Pangilinan Jasmyn , Andreopoulos William , LaButti Kurt , Daum Chris , Yoshinaga Yuko , Fauchery Laure , Ng Vivian , Lipzen Anna , Barry Kerrie , Singan Vasanth , Guo Jie , Lebel Teresa , Costa Mauricio Dutra , Grigoriev Igor V , Martin Francis , Anderson Ian C , Kohler Annegret 
Published: February 2023

AbstractThe mutualistic ectomycorrhizal (ECM) fungal genus Pisolithus comprises 19 species defined to date which colonize the roots of &gt;50 hosts worldwide suggesting that substantial genomic and functional evolution occurred during speciation. To better understand this intra-genus variation, we undertook a comparative multi-omic study of nine Pisolithus species sampled from North America, South America, Asia, and Australasia. We found that there was a small core set of genes common to all species (13%), and that these genes were more likely to be significantly regulated during symbiosis with a host than accessory or species-specific genes. Thus, the genetic “toolbox” foundational to the symbiotic lifestyle in this genus is small. Transposable elements were located significantly closer to gene classes including effector-like small secreted proteins (SSPs). Poorly conserved SSPs were more likely to be induced by symbiosis, suggesting that they may be a class of protein that tune host specificity. The Pisolithus gene repertoire is characterized by divergent CAZyme profiles when compared with other fungi, both symbiotic and saprotrophic. This was driven by differences in enzymes associated with symbiotic sugar processing, although metabolomic analysis suggest that neither copy number nor expression of these genes is sufficient to predict sugar capture from a host plant or its metabolism in fungal hyphae. Our results demonstrate that intra-genus genomic and functional diversity within ECM fungi is greater than previously thought, underlining the importance of continued comparative studies within the fungal tree of life to refine our focus on pathways and evolutionary processes foundational to this symbiotic lifestyle.
Ammonia mapping observations of the Galactic infrared bubble N49: Three NH3 clumps along the molecular filament
Authors: Kohno Mikito , Chibueze James O , Burns Ross A , Omodaka Toshihiro , Handa Toshihiro , Murase Takeru , Yamada Rin I , Nagayama Takumi , Nakano Makoto , Sunada Kazuyoshi , Tachihara Kengo , Fukui Yasuo 
Published: February 2023

Abstract
We have carried out the NH3(J, K) = (1, 1), (2, 2), and (3, 3) mapping observations toward the Galactic infrared bubble N49 (G28.83−0.25) using the Nobeyama 45 m telescope. Three NH3 clumps (A, B, and C) were discovered along the molecular filament with the radial velocities of ∼96, 87, and 89 km s−1, respectively. The kinetic temperature derived from the NH3(2, 2)/NH3(1, 1) shows Tkin = 27.0 ± 0.6 K enhanced at Clump B in the eastern edge of the bubble, where position coincides with massive young stellar objects (MYSOs) associated with the 6.7 GHz class II methanol maser source. This result shows the dense clump is locally heated by stellar feedback from the embedded MYSOs. The NH3 Clump B also exists at the 88 km s−1 and 95 km s−1 molecular filament intersection. We therefore suggest that the NH3 dense gas formation in Clump B can be explained by a filament–filament interaction scenario. On the other hand, NH3 Clumps A and C at the northern and southern sides of the molecular filament might be the sites of spontaneous star formation because these clumps are located ∼ 5–10 pc away from the edge of the bubble.
ALMA Band 6 high-resolution observations of the transitional disk around SY Chamaeleontis
Authors: Orihara Ryuta , Momose Munetake , Muto Takayuki , Hashimoto Jun , Liu Hauyu Baobab , Tsukagoshi Takashi , Kudo Tomoyuki , Takahashi Sanemichi , Yang Yi , Hasegawa Yasuhiro , Dong Ruobing , Konishi Mihoko , Akiyama Eiji 
Published: February 2023

AbstractIn this study, we reported the results of high-resolution (${0{^{\prime \prime}_{.}}14}$) Atacama Large Millimeter/submillimeter Array (ALMA) observations of the 225 GHz dust continuum and CO molecular emission lines from the transitional disk around SY Cha. Our high-resolution observations clearly revealed the inner cavity and the central point source for the first time. The radial profile of the ring can be approximated by a bright narrow ring superimposed on a fainter wide ring. Furthermore, we found that there is a weak azimuthal asymmetry in dust continuum emission. For gas emissions, we detected 12CO(2–1), 13CO(2–1), and C18O(2–1), from which we estimated the total gas mass of the disk to be 2.2 × 10−4 M ⊙ , assuming a CO/H2 ratio of 10−4. The observations showed that the gas is present inside the dust cavity. The analysis of the velocity structure of the 12CO(2–1) emission line revealed that the velocity is distorted at the location of the dust inner disk, which may be owing to a warping of the disk or radial gas flow within the cavity of the dust disk. High-resolution observations of SY Cha showed that this system is composed of a ring and a distorted inner disk, which may be common, as indicated by the survey of transitional disk systems at a resolution of ${\sim}{0{^{\prime \prime}_{.}}1}$.
Gender-specific differences in patients with psoriatic arthritis receiving ustekinumab or tumour necrosis factor inhibitor: real-world data
Authors: Van Kuijk Arno W R , Nurmohamed Mike T , Siebert Stefan , Bergmans Paul , de Vlam Kurt , Gremese Elisa , Joven-Ibáñez Beatriz , Korotaeva T V , Lavie Frederic , Sharaf Mohamed , Noël Wim , Theander Elke , Smolen Josef S , Gossec Laure , van der Horst-Bruinsma Irene E 
Published: February 2023

Abstract

Objective
Investigate effects of gender on disease characteristics and treatment impact in patients with PsA.

Methods
PsABio is a non-interventional European study in patients with PsA starting a biological DMARD [bDMARD; ustekinumab or TNF inhibitor (TNFi)]. This post-hoc analysis compared persistence, disease activity, patient-reported outcomes and safety between male and female patients at baseline and 6 and 12 months of treatment.

Results
At baseline, disease duration was 6.7 and 6.9 years for 512 females and 417 males respectively. Mean (95% CI) scores for females vs males were: clinical Disease Activity Index for Psoriatic Arthritis (cDAPSA), 32.3 (30.3, 34.2) vs 26.8 (24.8, 28.9); HAQ-Disability Index (HAQ-DI), 1.3 (1.2, 1.4) vs 0.93 (0.86, 0.99); total PsA Impact of Disease-12 (PsAID-12) score, 6.0 (5.8, 6.2) vs 5.1 (4.9, 5.3), respectively. Improvements in scores were smaller in female than male patients. At 12 months, 175/303 (57.8%) female and 212/264 (80.3%) male patients achieved cDAPSA low disease activity, 96/285 (33.7%) and 137/247 (55.5%), achieved minimal disease activity (MDA), respectively. HAQ-DI scores were 0.85 (0.77, 0.92) vs 0.50 (0.43, 0.56), PsAID-12 scores 3.5 (3.3, 3.8) vs 2.4 (2.2, 2.6), respectively. Treatment persistence was lower in females than males (P ≤ 0.001). Lack of effectiveness was the predominant reason to stop, irrespective of gender and bDMARD.

Conclusions
Before starting bDMARDs, females had more severe disease than males and a lower percentage reached favourable disease states, with lower persistence of treatment after 12 months. A better understanding of the mechanisms underlying these differences may improve therapeutic management in females with PsA.

Trial registration
ClinicalTrials.gov, https://clinicaltrials.gov, NCT02627768
News from the United Nations Commission on International Trade Law (UNCITRAL): the work of the 55th Commission session
Authors: Mostad-Jensen Anne 
Published: February 2023

Abstract
The United Nations Commission on International Trade Law (UNCITRAL) is the core legal body of the United Nations system in the field of international trade law. It has been carrying out its mandate to further the progressive harmonization and unification of international trade law since 1966.1 This article provides an overview of the 55th session of UNCITRAL and the activities of its working groups and Secretariat from mid-2021 to mid-2022. The annual UNCITRAL session (27 June to 15 July 2022, New York) was held fully in person for the first time since the start of the COVID-19 pandemic. Delegates and observers were also able to listen to the Commission session remotely via the UN webcast system but were not able to intervene using that format. Though the Commission session operated under normal conditions, the activities of the UNCITRAL working groups and the Secretariat during the year were still affected by the pandemic, with the meeting time with interpretation in all six UN languages reduced for hybrid meetings that were held both in-person and via Zoom.
Limiting Oral Intake during Labor: Do We Have It Right?
Authors: Palmer C.M. , Jiang Y. 
Published: February 2023

(Anesthesiology. 2022;136:528–530)
A recent study by Bouvet et al compared gastric emptying in 4 groups: laboring parturients with epidural analgesia, laboring parturients without epidural analgesia, nonlaboring pregnant women, and nonpregnant women. They found that, while laboring parturients had a slower rate of gastric emptying than nonpregnant and nonlaboring pregnant women, epidural analgesia did not slow gastric emptying but facilitated it. The majority (9 of 10) of laboring patients without epidural analgesia had solid food in their stomach 2 hours after ingesting a small meal, compared to only 3 of 10 patients who received epidural analgesia.
What is “Genuine” Failure of Neuraxial Anaesthesia?
Authors: Stanford SER 
Published: February 2023

(Anaesthesia. 2022;77:523–526)
The study conducted by Patel et al attempted to define inadequate neuraxial anesthesia (NA). While most medical staff present during cesarean delivery (CD) are comfortable in what can be a stressful environment, some clinicians may underestimate the distress of an awake patient during this major surgery and life event. Vogel and Hornitsky encourage understanding and responding to not only pain but also distress in order to create a bond of trust between the care providers and the patient.
Oocytes From Stem Cells
Authors: Herbert M. , Surani A. 
Published: February 2023

(N Engl J Med. 2022;386:188–190)
Development of mammalian oocytes initiates early in embryonic development, around day 16 in humans. Primordial germ cells develop independently from fetal gonads, then migrate to the gonads where they both follow a synchronized program of development. The primordial germ cells proliferate and mature to form oogonia, followed by meiosis which brings about the mature oocyte. Once fully developed, the number of embryonic oocytes are fixed throughout life into female adulthood. While oocyte formation and meiosis are genetically independent events, functional meiosis is essential for healthy oocytes that can transmit a single copy of each chromosome for normal sexual reproduction.
Diagnosis and Management of Gestational Trophoblastic Disease: 2021 Update
Authors: Ngan H.Y.S. , Seckl M.J. , Berkowitz R.S. , Xiang Y. , Golfier F. , Sekharan P.K. , Lurain J.R. , Massuger L. 
Published: February 2023

(Int J Gynaecol Obstet. 2021;155(suppl 1):86–93)
Gestational trophoblastic disease (GTD) is a premalignant disorder that derives from an abnormal placenta. Biomarker hormone human chorionic gonadotropin found in pregnancy and postpartum can help determine disease progression.
Associations Between Ethnicity and Admission to Intensive Care Among Women Giving Birth: A Cohort Study
Authors: Jardine J. , Gurol-Urganci I. , Harris T. , Hawdon J. , Pasupathy D. , van der Meulen J. , Walker K. ,   the NMPA Project Team
Published: February 2023

(BJOG. 2022;129:733–742)
Intensive care unit (ICU) admission among women giving birth is an indicator of severe maternal morbidity and is associated with a high risk of mortality. Studies in the United Kingdom have shown that patients from ethnic minority groups have worse maternal outcomes compared with White patients. Previous studies in the Netherlands, Canada, and the United States have shown an ethnic disparity in maternal ICU admissions. This study by Jardine et al aimed to determine the association between ethnicity and ICU admission among patients giving birth in the United Kingdom and Wales.
Changes in Obstetrical Practices and Pregnancy Outcomes Following the ARRIVE Trial
Authors: Gilroy L.C. , Al-Kouatly H.B. , Minkoff H.L. , McLaren R.A. 
Published: February 2023

(Am J Obstet Gynecol. 2022;226:716.e1–716.e12)
As cesarean delivery rates approach an all-time high in the United States and other developed countries, mothers and neonates are at increased risk for morbidities associated with this mode of birth. Data from the 2018 ARRIVE (A Randomized Trial of Induction Versus Expectant Management) trial showed a decrease in cesarean delivery rates and hypertensive disorders when obstetric practices shifted to prioritize induction for 39-week, low-risk, singleton, nulliparous births. Further, meta-analysis demonstrated 39-week inductions lower the risk of infection in the peripartum period, result in fewer NICU (neonatal intensive care unit) admissions and lessen perinatal mortality. As there is a well acknowledged “evidence-to-practice” gap it is not well understood if there has been wide-spread clinical uptake of the recommendation for obstetricians to offer induction to low-risk nulliparous women at 39 weeks. The question of broad change in obstetrical practice and perinatal outcomes following the ARRIVE trial is investigated.
Confidential Enquiry into Maternal Deaths in the Netherlands, 2006–2018
Authors: Kallianidis A.F. , Schutte J.M. , Schuringa L.E.M. , Beenakkers I.C.M. , Bloemenkamp K.W.M. , Braams-Lisman B.A.M. , Cornette J. , Kuppens S.M. , Rietveld A.L. , Schaap T. , Stekelenburg J. , Zwart J.J. , van den Akker T. 
Published: February 2023

(Acta Obstet Gynecol Scand. 2022;101:441–449)
The national maternal mortality ratio (MMR-quantified maternal deaths during pregnancy through 42 days postpartum per 100,000 live births) is an important metric for evaluating health care trends and allows for learning to improve care and prevent further death. While 90% of maternal deaths occur in low- and middle-income countries, from 1990 to 2015 some high-income countries saw increased MMR over previous decades. In the Netherlands, the rise of known risk factors including chronic hypertension and obesity, changes in national demographics, and reduced underreporting are considered significant contributors to the MMR increased observed from 1982-1992 (9.7 per 100,000 live births) to 1993-2005 (12.1). Further inquiry is necessary to update MMR in the Netherlands and evaluate new trends.
Utilization and Outcomes of Extracorporeal Membrane Oxygenation in Obstetric Patients in the United States, 1999-2014: A Retrospective Cross-sectional Study
Authors: Taha B. , Guglielminotti J. , Li G. , Landau R. 
Published: February 2023

(Anesth Analg. 2022;135:268–276)
Extracorporeal membrane oxygenation (ECMO) use for critically ill patients is increasing, but data on obstetric patients is lacking. This study analyzes ECMO utilization and outcomes of maternal obstetric patients in the United States.
Associations of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes
Authors: Magnus M.C. , Örtqvist A.K. , Dahlqwist E. , Ljung R. , Skår F. , Oakley L. , Macsali F. , Björn P. , Gjessing H.K. , Håberg S.E. , Stephansson O. 
Published: February 2023

(JAMA. 2022;327:1469–1477)
While pregnant patients are at a higher risk of severe COVID-19 infection, many may still be concerned about the safety of receiving the vaccines during pregnancy. There is evidence supporting the safety of the approved vaccines from the surveillance systems by the Center for Disease Control and Prevention, a few small studies, and data from unplanned pregnancies in the phase 3 vaccination trials. This study used data from Sweden and Norway to examine risk of adverse outcomes following COVID vaccination during pregnancy.
Anesthesiologists’ Perspectives on Why Dural Punctures Occur: A Multicenter International Survey
Authors: Orbach-Zinger S. , Heesen M. , Ioscovich A. , Shatalin D. , Aptekman B. , Weiniger C.F. , Eidelman L.A. , Frenkel A. , Beilin Y. , Katz D.J. , Schlosberg I. , Binyamin Y. 
Published: February 2023

(Reg Anesth Pain Med. 2022;47:249–250)
While risk factors for an accidental dural puncture (ADP) have been identified, we need a better understanding of modifiable etiologies. This survey of anesthesiologists aimed to collect clinician perspectives on contributing factors to ADP.
Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Women Undergoing Cesarean Delivery: An Updated Meta-analysis
Authors: Bellos I. , Pergialiotis V. 
Published: February 2023

(Am J Obstet Gynecol. 2022;226:510–523.e22)
Postpartum hemorrhage (PPH) affects 1% to 10% of pregnancies worldwide and is associated with high maternal morbidity and mortality rates. Early diagnosis, prophylactic oxytocin, and prompt treatment is the recommended strategy for reducing blood loss during PPH. Tranexamic acid (TXA) may reduce the risk of death in patients with PPH. While previous meta-analyses on the use of prophylactic TXA during cesarean delivery have only used small sample sizes, the recent Tranexamic Acid for Preventing Postpartum Hemorrhage Following a Cesarean Delivery (TRAAP2) trial is adequately powered and examined long-term risks of prophylactic TXA alongside the benefits. This meta-analysis aimed to compare prophylactic TXA with standard uterotonic agents alone in terms of efficacy and safety in patients having a cesarean delivery.
Conservative Management or Cesarean Hysterectomy for Placenta Accreta Spectrum: The PACCRETA Prospective Study
Authors: Sentilhes L. , Seco A. , Azria E. , Beucher G. , Bonnet M.P. , Branger B. , Carbillon L. , Chiesa C. , Crenn-Hebert C. , Dreyfus M. , Dupont C. , Fresson J. , Huissoud C. , Langer B. , Morel O. , Patrier S. , Perrotin F. , Raynal P. , Rozenberg P. , Rudigoz R.C. , Vendittelli F. , Winer N. , Deneux-Tharaux C. , Kayem G. ,   On behalf of the the PACCRETA Study Group
Published: February 2023

(Am J Obstet Gynecol. 2022;226:839.e1–24)
Placenta accreta spectrum (PAS) is a phenomenon where trophoblasts attach or penetrate the myometrium and occasionally into adjacent organs. This can cause complications with delivery such as massive blood loss and multiple organ failure and is associated with high levels of maternal morbidity. PAS is occurring with increased frequency. The principal option for women with PAS is cesarean hysterectomy; however, alternative approaches include leaving the placenta in situ (conservative management), thus preserving the woman’s fertility. Small prospective have demonstrated conservative management to be associated with improved outcomes but larger studies are needed. This study was designed to assess maternal recovery and outcomes after cesarean hysterectomy compared with conservative management.