bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advance care planning and a structured palliative plan in primary health care decrease cancer deaths in hospital: A prospective controlled non-randomized intervention trial
Authors: Driller Bardo , Talseth-Palmer Bente , Strømskag Kjell Erik , Hole Torstein , Brenne Anne-Tove 
Published: September 2023

Abstract
Background: Advance care planning (ACP) enables patients to define goals and preferences, reflecting a person’s wishes and current medical condition. Spending less time in hospital and not dying in hospital are advocated to be desirable outcomes in palliative care (PC). In 2015, 36% of cancer patients died in hospital and 13% died at home in Norway.
Method: From 2015 to 2022 this prospective controlled non-randomized intervention trial included and observed 151 cancer patients from the Romsdal region with or without an organized ACP conversation with a conclusive and structured palliative plan in primary health care (ClinicalTrials.gov Identifier: NCT02170168, June 23, 2014). The patients were identified through their contact with the local hospital, cancer outpatient clinic or hospital-based PC team.
Results: During the observation period, 135 patients died. Of these, 74 patients had a structured palliative plan (intervention (I) group) and 61 had not (control (C) group). Dying in hospital was significantly less common for patients in the I group compared to the C group (16.2% vs 34.4%; p=0.014; X2 (1, n = 135) = 6.00). Patients with the intervention were more likely to die at home (33.8% vs 29.5%) or in nursing home (50.0% vs 36.1%). There were no statistically significant differences between the groups according to days at home, in nursing home, or in hospital during the last 90 days of life. Observed differences between the groups when it came fulfilment of preferred place of death (PPOD) and actual place of death (APOD) on 109 patients (42.2% in I group and 26.7% in C group) did not reach statistical significance (p=0.096).
Conclusion: Organized ACP conversations with a conclusive and structured palliative plan in primary health care decreased the number of cancer deaths in hospital in our study. A structured ACP approach integrating palliative care into oncology within primary health care, supports patients´ preferences by changing the current care profile to a more outpatient care and is feasible within the Norwegian health care system.
Use of Photoacoustic Imaging to Study the Effects of Anemia on Placental Oxygen Saturation in Normoxic and Hypoxic Conditions
Authors: Noble Ronan M. N. , Kirschenman Raven , Wiedemeyer Alyssa , Patel Vaishvi , Rachid Jad-Julian , Zemp Roger J. , Davidge Sandra T. , Bourque Stephane L. 
Published: September 2023

Abstract
We aimed to evaluate fetal and placental oxygen saturation (sO2) in anemic and non-anemic pregnant rats throughout gestation using photoacoustic imaging (PAI). Female Sprague Dawley rats were fed an iron-restricted or iron-replete diet before and during pregnancy. On gestational days 13, 18, and 21, PAI was coupled with high resolution ultrasound to measure oxygenation of the fetus, whole placenta, mesometrial triangle, as well as the maternal and fetal faces of the placenta. PAI was performed in 3D, which allowed sO2 to be measured within an entire region, as well as in 2D, which enabled SO2 measurements in response to a hypoxic event in real time. Both 3D and 2D PAI were performed at varying levels of FiO2 (fraction of inspired oxygen). Iron restriction caused anemia in dams and fetuses, a reduction in fetal body weight, and an increase in placental weight, but overall had minimal effects on sO2. Reductions in FiO2 caused corresponding reductions in sO2 which correlated to the severity of the hypoxic challenge. Regional differences in sO2 were evident within the placenta, and between the placenta and fetus. In conclusion, PAI enables non-invasive measurement of sO2 both rapidly and with a high degree of sensitivity. The lack of overt changes in SO2 levels between control and anemic fetuses may suggest reduced oxygen extraction and utilization in the latter group, which could be attributed to compensatory changes in growth and developmental trajectories.
Treatment of 95 post-Covid patients with SSRIs
Authors: Rus Carla P. , de Vries Bert E.K. , de Vries Ingmar E.J. , Nutma Idelette , Kooij J.J. Sandra 
Published: September 2023

Abstract
After Covid-19 infection, 12.5% develops post-Covid-syndrome (PCS). Symptoms indicate numerous affected organ systems. After a year, chronic fatigue, dysautonomia and neurological and neuropsychiatric complaints predominate. In this study, 95 PCS patients were treated with selective serotonin reuptake inhibitors (SSRIs). This study used an exploratory questionnaire and found that two-thirds of patients had a reasonably good to strong response on SSRIs, over a quarter of patients had moderate response, while 10% reported no response. Overall, patients experienced substantial improved well-being. Brainfog and sensory overload decreased most, followed by chronic fatigue and dysautonomia. Outcomes were measured with three different measures that correlated strongly with each other. The response to SSRIs in PCS conditions was explained by seven possible neurobiological mechanisms based on recent literature on PCS integrated with already existing knowledge. Important for understanding these mechanisms is the underlying biochemical interaction between various neurotransmitter systems and parts of the immune system, and their dysregulation in PCS. The main link appears to be with the metabolic kynurenine pathway (KP) which interacts extensively with the immune system. The KP uses the same precursor as serotonin: tryptophan. The KP is overactive in PCS which maintains inflammation and which causes a lack of tryptophan. Finally, potential avenues for future research to advance this line of clinical research are discussed.
Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics
Authors: Shalem Ophir , Serebrenik Yevgeniy , Mani Deepak , Maujean Timothé , Burslem George 
Published: September 2023

Abstract
The field of induced proximity therapeutics is in its ascendancy but is limited by a lack of scalable tools to systematically explore effector-target protein pairs in an unbiased manner. Here, we combined Scalable POoled Targeting with a LIgandable Tag at Endogenous Sites (SPOTLITES) for the high-throughput tagging of endogenous proteins, with generic small molecule-based protein recruitment to screen for novel proximity-based effectors. We apply this methodology in two orthogonal screens for targeted protein degradation: the first using fluorescence to monitor target protein levels directly, and the second using a cellular growth phenotype that depends on the degradation of an essential protein. Our screens revealed a multitude of potential new effector proteins for degradation and converged on members of the CTLH complex which we demonstrate potently induce degradation. Altogether, we introduce a platform for pooled induction of endogenous protein-protein interactions that can be used to expand our toolset of effector proteins for targeted protein degradation and other forms of induced proximity.
Acute Kidney Injury in Critically Ill Older Adults: Estimated Glomerular Filtration Rate and Its Association With In-Hospital Mortality
Authors: Nascimento Ginivaldo Victor Ribeiro do , Teixeira Maria Clara Lopes , de Jesus Kezia França , Soares Isabella Melo , de Araújo Ludmila Carvalho 
Published: September 2023

Abstract
Background: Acute kidney injury (AKI) is a serious illness with high mortality rates, particularly in older adult patients in intensive care units (ICUs). Early detection of AKI is crucial to prevent complications, but creatinine-based eGFR could result in systematic bias in older patients.
Methods: This study aimed to analyze estimated glomerular filtration rate (eGFR) using the Berlin Initiative Study (BIS)-creatinine and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in older adult who developed AKI after admission in ICU and assess its association with mortality.
Results: A total of 36 patients who developed AKI during their ICU stay were included. The majority were women (66.7%), average age of 71.67 years. All patients required mechanical ventilation support and 91.7% required the administration of vasopressors during hospitalization, only 25% of the patients were notified to nephrologists. Initial serum creatinine levels appeared normal (0.87 ± 0.22 mg/dL), but eGFR values indicated reduced renal function, particularly using BIS-creatinine (33% vs 18.2%, CKD-EPI). Regarding KDIGO classification, 69% of the patients were classified as stage 1. Mortality was 88.9% and in the multivariate analysis, the factors associated were age (odds ratio [OR] 1.2, 95% confidence interval [CI]: 1.07-1.5, p = 0.049), persistent AKI (OR 16.20, 95% CI: 2.38-48.88, p = 0.026 and BIS-creatinine value < 60 mL/min/1.73 m² (OR 1.19, 95% CI: 1.07-4.79, p = 0.048). Serum creatinine alone was unsatisfactory screening test for evaluating renal function in older adult patients, leading to under-recognition of AKI.
Conclusion: In conclusion, monitoring renal function through eGFR calculation, particularly BIS-creatinine, is crucial for detection and management of AKI in older adult ICU patients. Lower eGFR values were associated with increased mortality. These findings emphasize the need for proper investigation and referral of older adults with renal injury to improve outcomes and reduce morbidity and mortality.
[68Ga]Ga-DOTATATE PET/CT Versus [18F]F-FDG PET/CT in Tenis Syndrome - a Head-to-head Comparison With Elevated and Suppressed Tsh Levels in Papillary Thyroid Carcinoma – a Pilot Study
Authors: Almeida Ludmila Santiago , Santos Allan , Assumpção Ligia , Costa Tiago Oliveira , Araújo Maidane , Lima Mariana , Zantut-Wittmann Denise Engelbrecht , Etchebehere Elba 
Published: September 2023

Abstract
BACKGROUND
TENIS syndrome (Thyroglobulin-Elevated Negative Iodine Scintigraphy) in differentiated thyroid carcinoma is characterized by reduced expression of sodium-iodine symporter, rising serum thyroglobulin levels (Tg), and negative whole-body [131I]Iodine scans. In such patients, somatostatin receptor imaging with [68Ga]Ga-DOTATATE PET/CT (SSR PET/CT) and [18F]F-FDG PET/CT (FDG PET/CT) can identify metastases. To compare the uptake pattern of SSR PET/CT and FDG PET/CT in papillary thyroid carcinoma (PTC) patients with TENIS Syndrome under two conditions: elevated (eTSH) and suppressed (sTSH) TSH serum levels. Based on imaging findings in these patients, we intend to identify potential candidates for peptide receptor radionuclide therapy (PRRNT). Fifteen patients with PTC and TENIS Syndrome were prospectively enrolled. All patients underwent both SSR PET/CT and FDG PET/CT with sTSH and eTSH. Images were blindly evaluated for differences in SUVmax values and lesion detectability. The reference standard consisted of neck ultrasound, CT, MRI, PET/CT, biopsy, and follow-up. Three patients were selected for PRRNT due to lesion uptake similar or higher than the liver.
RESULTS
On a per-patient and on a per-lesion based analysis, sTSH SSR PET/CT detected a greater number of cervical and distant LNs (both p = 0.0253 on per-patient and p = 0.0176 and p = 0.0391 on per-lesion, respectively) when compared to sTSH FDG PET/CT. Likewise, eTSH SSR PET/CT detected a greater number of patients with local recurrences (p = 0.0455) and distant LN metastases (p = 0.0143) and in a per-lesion based analysis greater number of cervical and distant LNs (p = 0.0337 and p = 0.0039, respectively) when compared to eTSH FDG PET/CT. No differences were found for lung and bone metastases. One of three patients submitted to 3 cycles of PRRNT presented with a visual partial response, a 20% reduction in quantitative analyses and stable disease regarding Tg and TgAb levels.
CONCLUSIONS
In patients with PTC and TENIS Syndrome, SSR PET/CT detected a greater number of loco-regional and distant LN metastases than FDG PET/CT with both sTSH and eTSH. One of 3 patients submitted to PRRNT presented a partial response to treatment. Our findings may impact in patient restaging, management and theranostics strategies with radiolabeled somatostatin analogs.
The effect of warming ropivacaine on ultrasound-guided subgluteal sciatic nerve block: a randomized controlled trial
Authors: He Jiliang , Ma Yijun , Zhou NanNan , Xu Jingpin , Wu Weidong , Jiang Jiajie , Zhang Fengjiang 
Published: September 2023

Abstract
Background Currently, no information is available on the influence of local anaesthetics at different temperatures on sciatic nerve block. This study aims to determine whether warming ropivacaine has an influence on the onset of subgluteal sciatic nerve block under the ultrasonic guidance .
Methods Fifty-four patients with distal lower limbs surgery were randomly allocated into warming group (group W, n = 27 ) or room tempeture gruop (group R, n = 27 ). A sciatic nerve block with subgluteal approach under ultrasound guidance was performed with either 30 ml of 0.5% ropivacaine at a temperature of 23℃for group R or 30 ml of 0.5% ropivacaine at a temperature of 30℃for group W. The sensory and motor blockade were assessed every 2 minutes over a 30-minute period following injection.The primary outcome was the onset of limb sensory block .
Results In comparison with the group R, the time to onset of motor and sensory block in group W was significantly reduced. No obvious differences for the satisfaction of patients and duration of anesthesia were discovered between both groups. No complications associated with nerve block were observed 2 days after surgery.
Conclusions Warming ropivacaine 0.5% to 30℃ received a significantly faster onset of anesthesia during subgluteal sciatic nerve block.
Trial registration The trial was registered on October 3, 2022 in the Chinese Clinical Trial Registry (https://www.chictr.org.cn/bin/project/edit?pid=181104), registration number ChiCTR2200064350.(03/10/2022).
Use of Ganoderma lucidum Grown on Agricultural Waste to Remove Antibiotics from Water
Authors: Salandez Vanessa , Emami Shiva , Taha Ameer Y. , Saponara Valeria La 
Published: September 2023

Abstract

Antibiotic-rich effluents from farming and medical applications into waterways pose a serious risk for antibiotic drug resistance, promoting a need for effective strategies of removal from the food chain and the environment. In this work, we show proof-of-concept laboratory-scale bioremediation experiments to remove antibiotics in synthetic wastewater. A white rot fungus, Ganoderma lucidum, was grown on biomass formed by agricultural waste from California (almond shells, cover crop stalks). Water containing or lacking Ganoderma lucidum was inoculated with twenty antibiotics from six different classes. The extent of antibiotic removal was measured at baseline and after 3 days with ultra-high pressure liquid chromatography coupled to tandem mass-spectrometry. The data were analyzed with a two-way repeated ANOVA for 17 antibiotics data sets meeting residuals' normality, and a mixed-effects model for 3 antibiotics sets that did not. Treatment with mycelial biomass caused a statistically significant reduction, compared to the baseline, in the concentration in 3 quinolones and 2 sulfonamides, after just 3 days. Our findings provide a first proof-of-concept to bioremediate certain antibiotics, (particularly quinolones), in synthetic wastewater and with repurposed agricultural waste.
Multi-Objective Optimization Design of Double Resilient Groove Metal Seat for Ball Valve in Liquid Hydrogen Receiving Stations
Authors: Li Shuxun , Zheng Mingxing , Wang YIxue , Yang Lingxia , Ma Tingqian 
Published: September 2023

Abstract
For the liquid hydrogen receiving station ball valve seat in ultra-low temperature working conditions the cold shrinkage deformation is easy to lead to valve seal failure. Design a dual-elastic groove metal valve seat and a preliminary assessment of its performance. the seat performance is optimized based on the RBF approximation model combined with the NSGA-II algorithm. Use the Spearman method to analyze the sensitivity analysis and determine the optimized design variable. Based on the maximum equivalent stress Smax, maximum deformation Dmax, minimum fatigue life Lmin, and mass M as the optimized goal, the optimal Latin superposition method samples the valve seat structure parameters, and the establishment of High-precision RBF proxy model combined with the NSGA-Ⅱ algorithm to find excellent PARETO cutting-edge solutions, comprehensively considering the performance requirements of valve seats to determine the optimal structural parameters of the valve seat. The maximum stress of the valve seat after the optimization decreased by 43.45%, the maximum deformation decreased by 45.33%, the quality was reduced by 22.49%, and the life expectancy increased by 114.11%. The finite element analysis of the seal verifies that the optimized seat has an excellent compensation effect under the ultra-low temperature conditions of liquid hydrogen.
Soluble TGF-β decoy receptor TGFBR3 exacerbates AD lesions by modifying microglial function
Authors: Zhou lijun , Wang Nan , Feng Wenzheng , Liu Xin , Xu Zihua , Wu Qiong , Chen Jiangxia , Jiao Xinming , Ning Xinyue , Qi Zhentong , Jiang Xiaowen , Zhao Qingchun 
Published: September 2023

Abstract
Alzheimer’s disease (AD) is one of the major causative factors that induces progressive dementia, which is characterized by memory loss and progressive neurocognitive dysfunction. To elucidate the molecular mechanism contributing to AD, we analyzed an RNA-seq cohort of temporal cortex in AD patients using a bioinformatics workflow and demonstrated that transforming growth factor beta receptor 3 is a crucial gene regulating AD. Nevertheless, soluble TGFBR3 (sTGFBR3) rather than membrane-bound TGFBR3 is abnormally elevated in AD patients and animals. We then demonstrated that sTGFBR3 knockdown restored spatial learning and memory deficits in APP/PS1 and STZ-induced tau hyperphosphorylation mice. Mechanistically, sTGFBR3 knockdown promoted microglial polarization to the M2 phenotype from the M1 phenotype, inhibited proinflammatory and chemotactic activity, and enhanced phagocytic activity. In addition, sTGFBR3 knockdown significantly reduced acute LPS-induced neuroinflammation and ameliorated STZ-induced neuronal function impairment. These findings suggest that sTGFBR3 is a potential therapeutic target for AD.
Predictive factors for esophageal stenosis in patients receiving prophylactic steroid therapy after endoscopic submucosal dissection for esophageal squamous cell carcinoma
Authors: Mizuno Junichi , Urabe Yuji , Oka Shiro , Konishi Hirona , Ishibashi Kazuki , Fukuhara Motomitsu , Tanaka Hidenori , Tsuboi Akiyoshi , Yamashita Ken , Hiyama Yuichi , Kotachi Takahiro , Takigawa Hidehiko , Yuge Ryo , Hiyama Toru , Tanaka Shinji 
Published: September 2023

Abstract
Background
Methods to prevent esophageal stenosis (ES) after endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell carcinoma (ESCC) have received increasing attention. Although steroid administration is a prophylactic treatment, steroid use may also be a risk factor for ES. Therefore, we retrospectively evaluated risk factors for refractory ES in patients administered prophylactic steroids after ESD for ESCC.
Methods
Among 795 patients with ESCC (854 lesions), 180 patients (211 lesions) who received preventive administration of local triamcinolone acetonide (TrA) and/or oral administration of prednisolone were enrolled. We compared the total number of endoscopic balloon dilatation (EBD) procedures performed for post-ESD ES and clinical findings (tumor size, a history of ESD or chemoradiation therapy [CRT], entire circumferential resection, muscle layer damage, supplemental oral prednisolone administration, EBD with TrA injection, and additional CRT) between patients with refractory and non-refractory ES. EBD was continued until dysphagia resolved.
Results
Univariate analysis revealed (non-refractory group vs. refractory group) tumor size (34.4 ± 1.5 vs. 46.2 ± 1.5, p < 0.01), a history of CRT (8/144 vs. 9/50, p = 0.023), entire circumferential resection (19/133 vs. 28/31, p < 0.01), and supplemental oral prednisolone administration (72/80 vs. 20/39, p = 0.013) to be significantly associated with refractory ES (≥ 8 EBD). Moreover, multivariate analysis revealed that a history of CRT and entire circumferential resection were independently associated with refractory ES. The withdrawal rates of EBD at 3 years were 96.1% (52/53) and 58.5% (39/59) in the non-refractory and refractory groups, respectively.
Conclusions
Our data suggest that entire circumferential resection and a history of CRT are risk factors for refractory post-ESD ES in ESCC, even with prophylactic steroid administration.
Efficacy of Iron Supplementation on Physical Capacity in Non-anaemic Iron Deficient Individuals: Protocol for an Individual Patient Data Meta-analysis
Authors: Dugan Cory , Peeling Peter , Burden Richard , Richards Toby 
Published: September 2023

Abstract

Background
A deficiency in iron stores is associated with various adverse health complications, which, if left untreated, can progress to states of anaemia, whereby there is significant detriment to an individual’s work capacity and quality of life due to compromised erythropoiesis. The most common methods employed to treat an iron deficiency include oral iron supplementation, and in persistent and/or unresponsive cases, intravenous iron therapy. The efficacy of these treatments, particularly in states of iron deficiency without anaemia, is equivocal. Indeed, both randomised control trials and aggregate data meta-analyses have produced conflicting evidence. Therefore, this study aims to assess the efficacy of both oral and intravenous iron supplementation on physical capacity, quality of life, and fatigue scores in iron deficient non-anaemic individuals using individual patient data (IPD) meta-analysis techniques.
Methods
All potential studies, irrespective of design, will be sourced through systematic searches on the following databases: Cochrane Central Register of Controlled Trials; MEDLINE Ovid; Embase Ovid; Web of Science: Science Citation Index Expanded; Web of Science: Conference Proceedings Citation Index-Science; Clinicaltrials.gov; World Health Organization (WHO) International Clinical Trials Registry Platform. Individual patient data from all available trials will be included and subsequently analysed in a two-stage approach. Predetermined sub-group and sensitivity analyses will be employed to further explain results.
Discussion
The significance of this IPD meta-analysis is one of consolidating a clear consensus to better inform iron deficient individuals of the physiological response associated with iron supplementation. The IPD approach, to the best of our knowledge, is novel for this research topic. As such, the findings will significantly contribute to the current body of evidence.
Registration:
PROSPERO CRD42020191739 (Additional file 1).