bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of Nardostachyos Radix et Rhizoma (NRER)-Salidroside in the Treatment of Premature Ventricular Beats Based on Network Pharmacology and Molecular Docking
Authors: Liu Shuyuan , Chen Haoyu 
Published: September 2023

Abstract
Objective
To analyse the mechanism of NRER-Salidroside in the treatment of premature ventricular tachycardia by using network pharmacology and molecular docking and to provide the basis for developing the use of clinical traditional Chinese medicine.
Method
The chemical compositions of NRER and salidroside were determined, and their related targets were predicted. The disease-related targets were obtained by searching the common disease databases Genecards, OMIM and TTD, and the intersection between the predicted targets and the disease targets was determined. Then, the STRING database was used to set up a network of protein‒protein interactions (PPIs) between NRER and salidroside and the common targets of PVB and establish a network of PPIs.
Result
Forty-one active components of NRSR-Salidroside were detected, with 420 potential targets of action, with a total of 1688 PVB targets, and the top 10 core targets of drug-disease degree values were AKT1, TNF, GAPDH, SRC, PPARG, EGFR, PTGS2, ESR1, MMP9, and STAT3. KEGG analysis indicated that its mechanism may be related to the calcium signalling pathway, cancer signalling pathway, AGE-RAGE signalling pathway and other pathways. Molecular docking suggested that most of the active ingredients of the NRSR-salidroside pairs were well bound to the core targets.
Conclusion
Based on novel network pharmacology and molecular docking validation research methods, we revealed for the first time the potential mechanism of salidroside in PVB therapy.
Mercury biomagnification in the food chain of a piscivorous turtle species (Testudines: Chelidae: Chelus fimbriata) in the Central Amazon, Brazil
Authors: Cunha Fábio Andrew G. , Forsberg Bruce R. , Vogt Richard C. , Domingos-Moreira Fabíola X.V. , Marshall Bruce G. , Brito Brendson C. , Sousa Otávio P. , Kasper Daniele , Santos Ana Laura , Andrade Marcelo Costa 
Published: September 2023

Abstract

Turtles are an excellent biological model for studies of heavy metal contamination due to their natural history and ecological attributes. Turtles have a large geographical distribution, occupy different aquatic habitats, and pertain to various trophic levels. The present study investigated mercury bioaccumulation in the carnivorous chelonian Chelus fimbriata (Matamata turtle) and Hg biomagnification in relation to its aquatic food chain in the middle Rio Negro, Amazonas, Brazil. Tissue samples of muscle, carapace (shell) and claws were collected from 26 C. fimbriata, and autotrophic energy sources found in the turtle’s aquatic habitat area. In addition, samples of dorsal muscle tissue were collected from 7 Cichla. The samples were collected in February-March of 2014 and analyzed for THg concentrations and carbon (δ13C) and nitrogen (δ15N) stable isotopes. The highest THg concentrations were found in claws (3780ng.g-1), carapace (3622ng.g-1) and muscle (403ng.g-1), which were found to be significantly different (F(2.73)=49.02 p<0.01). The average δ13C and δ15N values in Matamata samples were 11.9‰ and -31.7‰, respectively. The principal energy source sustaining the food chain of C. fimbriata was found to be plankton and periphyton, while δ15N values showed its trophic position to be 3 levels above the autotrophic energy sources. There was a positive correlation between THg concentrations and turtle size, while a significant relationship was found between THg and δ15N, showing strong biomagnification in the food chain of C. fimbriata y=0.13x+0.97; r²=0.31). However, total mercury concentrations found in Matamata turtles were below the consumption threshold indicated by the WHO and Brazilian Health Ministry.
Influence of a succinimide dispersant on the tribological performance of MoS2 nanoparticles
Authors: Benmansour Marina , Afanasiev Pavel , Galipaud Jules , Vacher Beatrice , Trillaud Victor , Joly-Pottuz Lucile , Dassenoy Fabrice 
Published: September 2023

Abstract
In this study, the effect of a polyisobutenyl succinimide (PIB) dispersant on the tribological performances of MoS2 nanoparticles used as lubricant additives in a PAO base oil was investigated. Friction tests were conducted in boundary lubrication regime, in a steel/steel sliding contact configuration, at room temperature and 100°C. The tribofilms formed on the rubbed surfaces were analyzed using X-ray Photoelectron Spectroscopy (XPS) and Transmission Electron Microscopy (TEM). The results show that the dispersant used in this work prevent the agglomeration/sedimentation of the nanoparticles and strongly improves their dispersion in the base oil. Its effect on the tribological performance of the nanoparticles was found to be temperature dependant. The best friction reducing properties were obtained at high temperature. It was also found that the dispersant strongly affects the tribofilm properties (chemical composition, thickness, MoS2 flake length…) and that the best reducing friction properties were obtained when long and scarcely MoS2 flakes aligned in the sliding directions compose the tribofilm.
Exploration of potent phosphate solubilizing bacteria with evaluating pesticide, heavy metal and antibiotic - resistant properties for application as biofertilizer
Authors: Sarkar Balaram , Bhakta Jatindra Nath 
Published: September 2023

Abstract

The present study aimed to explore the potent phosphate solubilizing bacteria (PSB) from the rhizosphere by isolation, screening and characterization to apply as P biofertilizer for improving the plants growth. Due to exhibiting the higher inorganic P solubilization (163.75–245.49 mg/l) property, four isolates (KUJ1PSB1, KUJ1PSB2, KUJ1PSB10 and KUJ1PSB12) were chosen as the potent PSB from a total of fourteen hollow zone exhibiting colonies grown on Pikovskaya’s agar media. Of four isolates, KUJ1PSB2 showed the highest inorganic P solubilization (245.49 ± 0.59 mg/l, 24.97–37.30%) and excellent plant (Solanum lycopersicum) growth promotion (shoot length − 30.43% and leaf number − 50%) efficiencies along with other favourable biochemical properties; indole acetic acid (IAA) production (96.06 µg/ml), pesticide-resistant (50–2000 mg/l), antibiotic-resistant (< 10 - >1000 mg/l), heavy metal -resistant (> 2000 mg/l) and -removal (Cd 93.1%, Zn 53.6%, Pb 72%, and Cu 49%). High P solubilization and IAA production efficiencies of KUJ1PSB2 are important factors for excellent plant growth. Therefore, KUJ1PSB2 was selected as the best PSB among four potential isolates and identified by the 16S rDNA sequencing. The 16S rDNA (1000 bp) sequence of KUJ1PSB2 showed 98.81% similarity with Serratia marcescens and a phylogenetic analysis revealed its position among the related species, which collectively identified it as Serratia marcescens KUJ1PSB2 strain. Finally, it can be concluded that Serratia marcescens KUJ1PSB2 would be a potential P solubilizing biofertilizer for applying in practical fields to produce sustainably higher rate of crop at low-cost through the organic agriculture practices and food production for the benefit of the farmers.
Determinants of Plant Species Richness Along Elevational Gradients: Insights with Climate, Energy and Water-Energy Dynamics
Authors: Kumar Abhishek , Patil Meenu , Kumar Pardeep , Singh Anand Narain 
Published: September 2023

Abstract

Understanding the patterns and processes of species distributions has long remained a central focus of biogeographical and ecological research. While the evidence for elevational patterns in species richness is widespread, our understanding of underlying causes and mechanisms remained limited. Therefore, this study aimed to entangle the influence of environmental variables on plant species richness along elevational gradients in the Western Himalayas. We compiled elevational distribution for about 1150 vascular plants using the published literature and available database. The species richness was estimated in 100-m elevational bands using the range interpolation method. We used the generalised linear model and structural equation modelling (SEM) framework to identify the direct and indirect effects of climatic factors on species richness. Our results indicated that primary environmental correlates of species richness varied with elevational gradients. Climatic variables combined with energy and water availability were more important than the topographic heterogeneity, suggesting that species richness is shaped by climatic tolerances rather than habitat diversity at larger scales. Further, the direct effects of climatic variables were more substantial than their indirect effects, indicating that climate directly influences metabolism and physiology. The indirect effects of climate are more mediated by water–energy dynamics than the energy alone. Overall, our findings emphasise the importance of considering direct effects and interactions among environmental variables while studying the underlying mechanisms governing elevational biodiversity gradients.
Longitudinal Patient-Reported Outcomes after Minimally Invasive McKeown Esophagectomy for Patients with Esophageal Squamous Cell Carcinoma
Authors: Miao Yan , Nie Xin , He Wen-Wu , Luo Chun-Yan , Xia Yan , Zhou Ao-Ru , Wei Si-Rui , Wang Cheng-Hao , Fang Qiang , Peng Lin , Leng Xue-Feng , Han Yong-Tao , Luo Lei , Xie Qin 
Published: September 2023

Abstract

Purpose
Surgery for esophageal squamous cell carcinoma (ESCC) is characterized by a poor prognosis and high complication rate, resulting in a heavy symptom burden and poor health-related quality of life (QOL). We evaluated longitudinal patient-reported outcomes (PROs) to analyze the correlations between symptoms and QOL and their changing characteristics during postoperative rehabilitation.
Methods
We investigated patients with ESCC who underwent minimally invasive McKeown esophagectomy at the XXX between April 2019 and December 2019. Longitudinal data of the clinical characteristics and PROs were collected. The MD Anderson Symptom Inventory and European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaires were used to assess symptoms and QOL and compare the trajectories of PROs during the investigation.
Results
A total of 244 patients with ESCC were enrolled in this study. Regarding QOL, role and emotional functions returned to baseline at 1 month after surgery, and cognitive and social functions returned to baseline at 3 months after surgery. However, physical function and global QOL did not return to baseline at 1 year after surgery. At 7 days and 1, 3, 6, and 12 months after surgery, the main symptoms of the patients were negatively correlated with physical, role, emotional, cognitive, and social functions and the overall health status (P < 0.05).
Conclusion
Patients with ESCC experience reduced health-related QOL and persisting symptoms after minimally invasive McKeown esophagectomy, but a recovery trend was observed within 1 month. The long-term QOL after esophagectomy is acceptable.
Histopathological Study and Immunohistochemistry of Mediastinal Masses of Anterior Compartment
Authors: Vemuluri Mounica , Philipose Thoppil Reba 
Published: September 2023

Background: The mediastinum is the mid portion of the thoracic cavity, further divided into the anterior, middle, and posterior mediastinum. The numerous organs within the mediastinum make it prone to the development of various lesions. About half of all mediastinal masses occur in the anterior compartment. The most common are thymoma, lymphoma and mature teratoma. An accurate histopathological diagnosis is required for the management of mediastinal lesions.
Methods: This is a 2-year prospective study conducted in the Department of Pathology on Biopsies and Resected Specimens of Anterior Mediastinal Masses (AMM) in a tertiary care hospital from September2020-September2022. Sections were studied after staining with hematoxylin and eosin(H&E). Immunohistochemical (IHC) stains were done wherever required.
Result: The present study included 58 cases of AMM. The age of the patients ranged from 2-77 years. Males constituted 68.90 % of cases. The male-to-female ratio was 5:2.2. Cough was the most common presenting symptom. Thymic pathology was detected in 56.8% of cases, of which thymoma is the most common. Thymoma presented with Myasthenia Gravis (M.G.) in 2 cases. Lymphoma constituted 12% of cases. Metastatic carcinoma in 12%, Extragonadal Germ Cell Tumor (EGCT) in 8.6% and lymphangioma in 3.4% cases. Lipoma, sarcoidosis and myofibroblastic tumor each constitute 1.72% cases.
Conclusion: The present study describes the various lesions of the anterior compartment.
Incidence Of Hemoglobinopathies In South Indian Population – 4 Year Study
Authors: A Kavitha - , V Kavita , . Mukilarasi 
Published: September 2023

Background
Hemoglobinopathies are very common, but majority being asymptomatic it is under diagnosed. Hemoglobinopathies are important health care threat in tropical countries. The present study analyzed the incidence of hemoglobinpathies in south Indian population reported in regional laboratory in Chennai catering Tamil nadu and Andhra Pradesh population.
Methods
A cohort of samples which was received for abnormal hemoglobinopathy studies for evaluation of anemia and prenatal screening from Tamil nadu and Andrapradesh population for 4 years was analyzed using capillary electrophoresis method in (Sebia Minicap instrument) for incidence of hemoglobinopathies.
Result
Total number of cases studied during 4 years (2018-2022) is 17678, Of which 1194(7%) were detected with hemoglobinopathy/ abnormal hemoglobin variant. Of which 56.28% were female and 43.72% were male. Common age group under study is 21-30(30.07%). Beta thalassemia trait was detected at the highest frequency (69.13%) followed by HbE-Beta thalaseemia(6.87%) and least being HbD homozygous.
Conclusion
Our study analyzed a cohort and reported a spectrum of hemoglobin variants and its incidence in Tamil nadu and Andhrapradesh population.
Multi-energy system smart tool for ecological water body restoration using an AI-based decision-making framework
Authors: Xu Shu , Hsu Ching-Hsien , Montenegro-Marin Carlos Enrique 
Published: September 2023

Abstract
Ecological regeneration will reduce air pollution, reverse forest clearing and wilderness, minimize loss of biodiversity, improve urban ecosystems, and probably enhance the livelihoods and ties between mankind and nature. Ecological regeneration risk factors include frequent changes in natural environments, imperfect interpretation of natural systems by humans, and a lack of knowledge on past successes and shortcomings. The Internet of Things (IoT) uses in environmental monitoring are varied: environmental protection, extreme weather monitoring, water safety, conservation of endangered species, and commercial farming. In this paper, artificial intelligence-based environmental decision restoration framework (AI-EDRF) has been proposed to strengthen the continuously evolving natural systems; people are deficient about natural systems and the insufficient knowledge about past achievements and failures. The biological terrestrial collective analysis is introduced to improve natural systems is rapidly evolving, and people are inadequately aware of natural systems. Stochastic water quality analysis is integrated with AI-EDRF to boost past achievements and failures. IoT-enabled smart energy management is an effective approach to provide cost-effective, efficient energy distribution and technologies are used in connection with sustainable, renewable energy sources. The computational analysis is executed based on accuracy, performance ratio, reaction time, and data deployment to verify the developed framework's reliability.
Integrated systems for rainwater harvesting and greywater reuse: a systematic review of urban water management strategies
Authors: Rodrigues A. M. , Formiga K. T. M. , Milograna J. 
Published: September 2023

AbstractCombined, decentralized systems for rainwater harvesting and greywater reuse may enhance the water security of urban areas by reducing dependence on the main water supply, in particular during critical periods, such as the dry season. They can also minimize the risk of flooding during the rainy season. The present study assesses the accumulated knowledge of these combined systems based on a systematic review of the literature restricted to academic sources. The review revealed knowledge gaps that must be resolved to better assess the optimum combination of rainwater and greywater recovery, how this affects the need for the treatment of the recovered water, its final quality, potential options for reuse, water economy, and the environmental and economic performance of the system. Further empirical studies are required to determine the most adequate design configuration for these systems, considering their multiple objectives, technological perspectives, and in particular, their potential for improving environmental shortcomings. There is a clear need for widespread use of low-impact technologies to ensure the most effective possible results. Water recovery systems will become increasingly important as a means of tackling the challenges of water supplies in the urban landscape, which are being exacerbated by climate change.
Antimicrobial Bacterial Metabolites: Properties, Applications and Loading in
Liposomes for Site-specific Delivery
Authors: Valença Camilla A.S. , Barbosa Ana A.T. , Dolabella Silvio S. , Severino Patricia , Matos Carla , Krambeck Karolline , Souto Eliana B. , Jain Sona 
Published: September 2023

Abstract:
The high levels of antibiotic resistance registered worldwide have become a serious health problem,
threatening the currently available treatments for a series of infectious diseases. With antibiotics becoming less
and less effective, it is becoming increasingly difficult and, in some cases, impossible to treat patients with
even common infectious diseases, such as pneumonia. The inability to meet the ever-increasing demand to control
microbial infection requires both the search for new antimicrobials and improved site-specific delivery. On
the one hand, bacterial secondary metabolites are known for their diverse structure and antimicrobial potential
and have been in use for a very long time in diverse sectors. A good deal of research is produced annually describing
new molecules of bacterial origin with antimicrobial properties and varied applications. However, very
few of these new molecules reach the clinical phase and even fewer are launched in the market for use. In this
review article, we bring together information on these molecules with potential for application, in particular, for
human and veterinary medicine, and the potential added value of the use of liposomes as delivery systems for
site-specific delivery of these drugs with the synergistic effect to overcome the risk of antibiotic resistance.
Recent Advances in Nanobiotechnology for the Treatment of
Non-Hodgkin’s Lymphoma
Authors: Liu Shuxian , Xu Minghao , Zhong Lei , Tong Xiangmin , Qian Suying 
Published: September 2023

Abstract:
Lymphoma is the eighth most common type of cancer worldwide. Currently, lymphoma is
mainly classified into two main groups: Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma
(NHL), with NHL accounting for 80% to 90% of the cases. NHL is primarily divided into B, T, and
natural killer (NK) cell lymphoma. Nanotechnology is developing rapidly and has made significant
contributions to the field of medicine. This review summarizes the advancements of nanobiotechnology
in recent years and its applications in the treatment of NHL, especially in diffuse large B cell lymphoma
(DLBCL), primary central nervous system lymphoma (PCNSL), and follicular lymphoma
(FL). The technologies discussed include clinical imaging, targeted drug delivery, photodynamic therapy
(PDT), and thermodynamic therapy (TDT) for lymphoma. This review aims to provide a better
understanding of the use of nanotechnology in the treatment of non-Hodgkin's lymphoma.
A Sustainable Approach Towards Prevention and Treatment of Hepatic
and Other Disorders Associated with Alcohol Consumption
Authors: Nooreen Zulfa , Shukla Ankita , Shukla Anuja , Verma Priyanka 
Published: September 2023

Background:
Alcohol has been used for centuries in many different civilizations. It is a
psychoactive stimulant with addictive properties. Alcohol misuse has significant negative social, economic,
and health effects. Abusing alcohol can cause harm to oneself as well as to relatives, coworkers,
close companions, and total strangers. Alcohol usage contributes to more than 200 diseases, accidents,
and other health problems. Drinking alcohol is associated with a higher chance of developing
significant non-communicable illnesses such liver cirrhosis, a number of cancers, cardiovascular diseases,
as well as behavioral and mental disorders like alcoholism.

Objective:
Abuse of alcohol does not occur suddenly. People becoming addicted to various alcoholic
beverages is a problem that results from months and years of irresponsible drinking. The process of
recovering from the issue in turn includes targeted, particular methods for raising awareness of the
negative effects of alcohol usage.

Conclusion:
Due to the heightened risks for one's bodily and mental health along with the social issues
it generates, alcohol consumption results in these costs. We discuss the three areas of the epidemiology
of alcohol's impact on health and diseases, the public health approach for treating problems
related to alcohol use,and advancements in alcohol science.
Multiple Sclerosis: New Insights into Molecular Pathogenesis and Novel
Platforms for Disease Treatment
Authors: Dejbakht Majid , Akhzari Morteza , Jalili Sajad , Faraji Fouziyeh , Barazesh Mahdi 
Published: September 2023

Background:
Multiple sclerosis (MS), a chronic inflammatory disorder, affects the central
nervous system via myelin degradation. The cause of MS is not fully known, but during recent
years, our knowledge has deepened significantly regarding the different aspects of MS, including
etiology, molecular pathophysiology, diagnosis and therapeutic options. Myelin basic protein
(MBP) is the main myelin protein that accounts for maintaining the stability of the myelin sheath.
Recent evidence has revealed that MBP citrullination or deamination, which is catalyzed by Ca2+
dependent peptidyl arginine deiminase (PAD) enzyme leads to the reduction of positive charge,
and subsequently proteolytic cleavage of MBP. The overexpression of PAD2 in the brains of MS
patients plays an essential role in new epitope formation and progression of the autoimmune disorder.
Some drugs have recently entered phase III clinical trials with promising efficacy and will
probably obtain approval in the near future. As different therapeutic platforms develop, finding an
optimal treatment for each individual patient will be more challenging.

Aim:
This review provides a comprehensive insight into MS with a focus on its pathogenesis and
recent advances in diagnostic methods and its present and upcoming treatment modalities

Conclusion:
MS therapy alters quickly as research findings and therapeutic options surrounding
MS expand. McDonald's guidelines have created different criteria for MS diagnosis. In recent
years, ever-growing interest in the development of PAD inhibitors has led to the generation of
many reversible and irreversible PAD inhibitors against the disease with satisfactory therapeutic
outcomes.