bluuebunny/crossref_metadata_2025_split huggingface dataset:
The phylogenetic position and analysis of Renicola and Apharyngostrigea species isolated from Cattle Egret (Bubulcus ibis)
Authors: Salem Mai A. , Mahdy Olfat A. , Shaalan Mohamed , Ramadan Reem M. 
Published: September 2023

AbstractCattle Egret (Bubulcus ibis) is one of the most well-known herons in Egypt. It is called the friend of the farmer because it benefits farmers and helps them get rid of insects and worms. It acts as a reservoir for many diseases. Few researchers have discussed the significance of parasitic diseases that affect this wild bird and may lead to mortalities among the population especially the importance of vital organs such as kidneys. Therefore, this study aimed to spotlight parasitic infection-affected herons in Egypt and consider the risks to this beneficial bird. During this study, 23 Bubulcus ibis were captured after their death from Abou Rewash Giza Governorate, Egypt, during the period from February to September (2022). Renicola species (spp.) and Apharyngostrigea spp. are two important digenean parasites that were recovered from the kidneys, and small intestine of the heron Cattle Egret (Bubulcus ibis) with an infection rate of (17.2%) and (11.8%) respectively. Histopathological techniques were used to assess tissue alterations while light microscopy and molecular assays were used to assess the parasites. The parasites’ morphological and morphometrical characteristics, as well as polymerase chain reaction and sequencing assays (mitochondrial sections), were investigated for the first time in Egypt. These parasites were given in-depth illustrations and drawings. The distinctive qualities of the two species were discussed. As the first record from Egypt, the nucleotide sequences discovered in this work have been uploaded into the GenBank database (accession numbers: OR021986 and OQ955829). Microscopically, the renal blood vessels had vasculitis, necrosis, and other degenerative alterations. Further research analyzing the health of various heron spp. and environmental deterioration can help to close information gaps about the interactions between parasites, their hosts, and environmental health.
Identification and verification of genes associated with hypoxia microenvironment in Alzheimer’s disease
Authors: Yuan Mingyang , Feng Yanjin , Zhao Mingri , Xu Ting , Li Liuhong , Guo Ke , Hou Deren 
Published: September 2023

AbstractAs the incidence of Alzheimer's disease (AD) increases year by year, more people begin to study this disease. In recent years, many studies on reactive oxygen species (ROS), neuroinflammation, autophagy, and other fields have confirmed that hypoxia is closely related to AD. However, no researchers have used bioinformatics methods to study the relationship between AD and hypoxia. Therefore, our study aimed to screen the role of hypoxia-related genes in AD and clarify their diagnostic significance. A total of 7681 differentially expressed genes (DEGs) were identified in GSE33000 by differential expression analysis and cluster analysis. Weighted gene co-expression network analysis (WGCNA) was used to detect 9 modules and 205 hub genes with high correlation coefficients. Next, machine learning algorithms were applied to 205 hub genes and four key genes were selected. Through the verification of external dataset and quantitative real-time PCR (qRT-PCR), the AD diagnostic model was established by ANTXR2, BDNF and NFKBIA. The bioinformatics analysis results suggest that hypoxia-related genes may increase the risk of AD. However, more in-depth studies are still needed to investigate their association, this article would guide the insights and directions for further research.
DNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment
Authors: Herzog Chiara , Jones Allison , Evans Iona , Zikan Michal , Cibula David , Harbeck Nadia , Colombo Nicoletta , Rådestad Angelique Flöter , Gemzell-Danielsson Kristina , Pashayan Nora , Widschwendter Martin 
Published: September 2023

AbstractTo individualise breast cancer (BC) prevention, markers to follow a person’s changing environment and health extending beyond static genetic risk scores are required. Here, we analysed cervical and breast DNA methylation (n = 1848) and single nucleotide polymorphisms (n = 1442) and demonstrate that a linear combination of methylation levels at 104 BC-associated methylation quantitative trait loci (mQTL) CpGs, termed the WID™-qtBC index, can identify women with breast cancer in hormone-sensitive tissues (AUC = 0.71 [95% CI: 0.65–0.77] in cervical samples). Women in the highest combined risk group (high polygenic risk score and WID™-qtBC) had a 9.6-fold increased risk for BC [95% CI: 4.7–21] compared to the low-risk group and tended to present at more advanced stages. Importantly, the WID™-qtBC is influenced by non-genetic BC risk factors, including age and body mass index, and can be modified by a preventive pharmacological intervention, indicating an interaction between genome and environment recorded at the level of the epigenome. Our findings indicate that methylation levels at mQTLs in relevant surrogate tissues could enable integration of heritable and non-heritable factors for improved disease risk stratification.
Realization of non-Hermitian Hopf bundle matter
Authors: Kim Yung , Park Hee Chul , Kyung Minwook , Lee Kyungmin , Ryu Jung-Wan , You Oubo , Zhang Shuang , Min Bumki , Park Moon Jip 
Published: September 2023

AbstractNon-trivial linking invariant encodes robust information of topological matter. It has been recently shown that the linking and winding of complex eigenenergy strings can classify one-dimensional non-Hermitian topological matter. However, in higher dimensions, bundles of linked strings can emerge such that every string is mutually linked with all the other strings. To the best of our knowledge, a non-Hermitian Hopf bundle has not been experimentally clarified. Here, we attempt to explore the non-Hermitian Hopf bundle by visualizing the global linking structure of spinor strings in the momentum space of a two-dimensional electric circuit. By exploiting the flexibility of reconfigurable couplings between circuit nodes, we study the non-Hermitian topological phase transition by exploring the intricate structure of the Hopf bundle. Furthermore, we find that the higher-order skin effect in real space is accompanied by the linking of spinor strings in momentum space, revealing bulk-boundary correspondence between the two domains.
Checkliste Injektionen
Authors: Vetter Karl 
Published: September 2023

SummaryAls invasive Maßnahme bedeuten Injektionen einen Eingriff in die körperliche Unversehrtheit, der erst durch Aufklärung, Einwilligung, Verhältnismäßigkeit sowie korrekte Vorbereitung und Durchführung zulässig wird. Zur Vorbereitung zählen unter anderem sorgfältige Indikationsstellung, „5-R-Regel“, Patienteninformation, Prüfung von Kontraindikationen, Vollständigkeit und Eignung des Materials sowie Hygiene. Für die Durchführung einer Injektion sind Kriterien wie Desinfektion, Kanülengröße, Injektionsstellen, Hygiene, Beobachtung und Entsorgung zu beachten.
Akupunktur – eine „feine“ invasive Methode
Authors: Bögel-Witt Martina 
Published: September 2023

SummarySummary: Die 3 großen traditionellen Akupunkturkonzepte stellen jeweils die Wandlungsphasen (5 Elemente), die Zang Fu oder die Leitbahnen in den Mittelpunkt. Bei Störungen der Wandlungsphasen (Fülle, Leere) oder der Zang Fu (Yin- und Yang-Organe) wird jeweils nach deren Prinzipien akupunktiert, während sich bei Beschwerden des Bewegungsapparates und Schmerzen die Leitbahnen-Akupunktur anbietet. Die Methoden lassen sich sehr gut kombinieren – so auch im vorgestellten Fall, in dem chronische Kopfschmerzen bereits nach einer Sitzung durch Akupunktur nach Leitbahnen und Wandlungsphasen verschwanden.
Ganz schön stachelig!
Authors: Stern Cornelia 
Published: September 2023

SummaryEinige Pflanzen haben stechende, brennende oder haftende Teile ausgebildet, die vorwiegend ihrem eigenen Schutz dienen oder bei ihrer Verbreitung hilfreich sind. Diese Teile sind auffällige und sogar spürbare Zeichen, mit denen die Pflanzen zu uns „sprechen“ und die in der Signaturenlehre eine wichtige Rolle spielen. Ob sie etwa venusische, marsianische oder ein Miteinander beider Aspekte zeigen – die Signaturen der ausgewählten Beispiele zeigen Möglichkeiten auf, wie man die Pflanzen heilsam einsetzen kann.
Den Nerv getroffen
Authors: Rathay Uwe 
Published: September 2023

SummaryFür Heilpraktiker gehört die Neuraltherapie – auch nach Einführung der Verschreibungspflicht für Procain und Lidocain 2006 – mit den nun zulässigen Konzentrationen bis 2 % (intrakutan) sowie mit procain- und lidocainfreien Mischinjektionen zu den wichtigsten Störfeldtherapien. Das Prinzip besteht im Identifizieren und Anspritzen eines Störfeldes, des zugehörigen Segmentes oder der zuständigen vegetativen Ganglien, um die ursächliche sympathikotone Reizung auszuschalten und damit wieder eine normale Regulation herzustellen. In den 2 vorgestellten Fällen klingen verletzungsbedingte Knieschmerzen sowie Magenbeschwerden nach wenigen Injektionen ab.
Vergebung – (k)ein Thema für die Psychotherapie?
Authors: Textor Reinhard 
Published: September 2023

SummaryVertrauen ist die Grundlage jeder Gemeinschaft. Jeder Bruch dieses Vertrauens stellt eine Verletzung dar. Der Weg zur Heilung ist kein leichter und setzt voraus, dass sich die Partner auf einen Klärungsprozess einlassen können und wollen. Nur wenn der Therapeut unparteiisch ist und für beide Partner das gleiche Verständnis und Mitgefühl aufbringt, gelingt die psychotherapeutische Begleitung dieses Prozesses. Ziel ist es, sowohl Täter als auch Opfer von der gedanklichen und emotionalen Bindung an die Vergangenheit zu befreien. Wie das geschilderte Praxisbeispiel zeigt, kann der Weg der Vergebung – ein Konzept, das Friedensnobelpreisträger Desmond Tutu vorgestellt hat – in der Paartherapie hilfreich sein: Wenn die Verletzung benannt wird, wenn Schuld und Scham überwunden werden, kann durch Vergebung wieder Vertrauen erwachsen.
Auswirkungen eines hohen Geburtsgewichts auf die Entwicklung von
Kindern im Vorschulalter
Authors: Berge Valerie , Thyen Ute 
Published: September 2023

Zusammenfassung
Hintergrund Ein hohes Geburtsgewicht über 4000 g kann zu
Risiken in der Entwicklung betroffener Kinder führen. Der Zusammenhang
ist weniger untersucht als die Auswirkungen eines sehr niedrigen
Geburtsgewichtes und ist Gegenstand dieser Studie.
Methoden Das retrospektive Studiendesign verwendet Daten aus den
Schuleingangsuntersuchungen in Schleswig-Holstein (Deutschland), die
2014–2017 erhoben wurden und 88858 Kinder im Alter von 5–6
Jahren einschlossen. Untersucht wurden die Endpunkte Sprache, Motorik, Kognition
und Verhalten, die Inanspruchnahme von Fördermaßnahmen sowie die
Empfehlung für schulischen Förderbedarf. Logistische
Regressionsmodelle wurden verwendet, um den Zusammenhang zwischen dem
Geburtsgewicht und den Zielgrößen unter Berücksichtigung
soziodemographischer Einflussfaktoren zu schätzen.
Ergebnisse Unter Berücksichtigung soziodemographischer Faktoren
ist ein hohes Geburtsgewicht nicht mit einer beeinträchtigten kindlichen
Entwicklung assoziiert, wohingegen sich ein niedriges Geburtsgewicht als
signifikanter Prädiktor erweist. Über alle Geburtsgewichte
gesehen erklären soziodemographische Faktoren den
größten Anteil der Varianz in den multivariaten Modellen zum
Einfluss des Geburtsgewichtes auf die kindliche Entwicklung.
Schlussfolgerungen Ein sehr hohes Geburtsgewicht rechtfertigt eine
allgemeine Empfehlung für Fördermaßnahmen nicht. Daher
sollten die individuellen Entwicklungsverläufe beobachtet werden. Das
Aufwachsen in benachteiligten Lebensumständen kann ein bedeutsames
Risiko darstellen und sollte Anlass für eine frühe
Förderung sein.
Exploring the Catalytic Efficiency of Copper-Doped Magnetic Carbon Aerogel for the Coupling Reaction of Isatin Oxime with Phenylboronic Acid Derivatives
Authors: Mishra Vivek , Mudgal Deeksha , Singh Ravi Pratap , Yadav Nisha , Bharti Tapeesh 
Published: September 2023

AbstractA highly efficient catalyst, Cu-doped poly(N-[3-(dimethylamino)propyl]methacrylamide, acrylic acid, N-vinyl imidazole) (PDAI) magnetic carbon aerogel (CPIMCA), was successfully employed for the synthesis of isatin nitrone derivatives. The 3D porous CPIMCA catalyst demonstrated outstanding performance through the application of a coupling reaction between isatin oxime and phenylboronic acid derivatives, providing up to 98% yield of the required nitrone derivatives. Remarkably, the incorporation of copper within the polymeric structure of the magnetic carbon aerogel exhibited a significant influence on catalytic activity, even at a low overall copper content of approximately 2%. This was confirmed through EDX elemental mapping analysis, further establishing the competence of the catalyst for catalytic reactions. Comparative studies revealed that CPIMCA outperformed Cu(Oac)2 catalyst, providing a notable 10–15% increase in product yield. This superior performance can be attributed to the unique synergistic effect of copper, iron, and carbon aerogel as the polymeric matrix, highlighting the exceptional capabilities of CPIMCA as a catalyst.
Anatomical Justification of Extradural Resection of the Anterior Clinoid Process
Authors: Sufianov Albert A. , Iakimov Iurii A. , Garifullina Nargiza A. , Sufianov Rinat A. , Kovalenko Roman V. , Kosimzoda Idrisdzhoni A. 
Published: September 2023

Abstract
Objective The study aimed to provide neuroanatomical justification of the extradural resection of the anterior clinoid process (ACP).
Material and Method Using a cross-sectional study design, 47 cranial computed tomography (CT) scans were examined. There were 31 (65.96%) females aged 28 to 79 years. The measured dimensions were ACP length and width, and optic strut (OS) width. Index (iacp) was measured as the ratio of ACP width to ACP length. The ACP volume and working operating field (WOF) volume were measured using Syngo.via Siemens program. The percentage expansion of WOF after removal of the ACP was estimated on 5 fixed human cadaver heads with the exoscope VITOM 3D. The possibilities of the combined approach were demonstrated in a clinical case.
Results The mean ACP lengths were 11.31 ± 2.76 and 11.54 ± 2.86 mm, on the right and left, respectively. The mean ACP widths were 7.70 ± 1.66 and 7.64 ± 1.67 mm, on the right and left, respectively. Average iacp was 0.67 (minimum 0.45; maximum 0.90). The width of the OS varied in the range from 1.37 to 4.75 mm. The average volume of right ACP was 0.71 ± 0.16 cm3, right WOF was 3.26 ± 0.74 cm3, left ACP was 0.71 ± 0.15 cm3, left and WOF was 3.20 ± 0.76 cm3. Removal of the right ACP expanded the right WOF by 22.21 ± 3.88%, and left ACP by 22.78 ± 5.50%. There was an approximately 25% increase in the WOF from the cadaveric dissections. Taking into account the variability of the ACP and OS, we proposed our own surgical classification of complicated (iacp ≥ 0.67; medium OS 2.5 mm ≤ 4.0 mm; wide OS ≥ 4.0 mm; ACP with pneumatization) and uncomplicated ACP (iacp 0.45 ≤ 0.67 mm; iacp ≤ 0.45; narrow OS ≤ 2.5 mm; ACP without pneumatization). Using this classification, we developed an algorithm for ACP dissection and removal. This was piloted in a clinical case of microsurgical clipping of a left internal carotid artery-posterior communicating artery aneurysm via the left minipterional approach.
Conclusion Extradural removal of ACP expands the WOF by approximately 25%, it helps neurosurgeons to improve proximal vascular control and avoid complications, and expands the range of indications for neurosurgical interventions in the skull base area.
Research on the Effects of Neuroglobin on Ferroptosis in the Nerve Cells
Authors: Gao Wenjin , Mo Chen , Feng Wei , Pan Xinmin , Qin Haojie 
Published: September 2023

Abstract
Objectives The objective of this article was to explore the effects of neuroglobin (NGB) on ferroptosis in the nerve cells.
Methods The NGB knockdown model of HT22 cells was constructed, and the ferroptosis-related indexes of cell proliferation activity, contents of iron ion, malondialdehyde (MDA), superoxide and reactive oxygen, and the changes of nuclear factor E2-related factor 2 (Nrf2) expression were examined in the normal group, erastin group, NGB siRNA group, and NGB siRNA + Erastin group, respectively.
Results Compared with the normal group, cell proliferation activity and Nrf2 expression were significantly lower in the erastin group, NGB siRNA group, and NGB siRNA + erastin group, and ferroptosis-related indexes such as iron ion content, MDA content, superoxide content, and reactive oxygen species content were significantly reduced, and the difference between NGB siRNA + erastin group, erastin group, and NGB siRNA group was statistically significant (p < 0.05).
Conclusion Knockdown of NGB in cells enhances the action of the ferroptosis inducer erastin, and NGB may regulate the cellular ferroptosis process through Nrf2. This research may provide references for the clinical treatment of nervous system disease with Chinese medicine.
Understanding the Gap Between Nursing Workforce in the United States and Population Needs—A Policy Brief
Authors: Al Mohajer Mayar 
Published: September 2023

Abstract
Purpose This report is intended to analyze the root causes for the current gap between the nursing workforce and population needs in the United States. It aims to consolidate what is known about these contributing reasons and provide evidence-based recommendations for action.
Methods The report utilized the Sample, Phenomenon of Interest, Design, Evaluation, Research type framework to develop the research question and the 5 Whys methodology for the root cause analysis.
Results This report highlighted six major causative problems, including workforce market mismatch, poor financing design, inadequate governance, flawed technologies, insufficient research, and suboptimal service delivery. A detailed evaluation of root causes with supported evidence is presented.
Conclusion The report provided seven actionable recommendations based on the analysis: (1) strengthening the nursing role in advancing equity, (2) investing in nursing well-being, (3) changing policies and payment structure, (4) including nursing in technology design, (5) strengthening nursing education, (6) developing a robust public health emergencies preparedness plan, and (7) investing in relevant research.
The Effect of Chemotherapeutic Agents on Survival in Metastatic Non-Small-Cell Lung Cancer with KRAS Mutation
Authors: Duygulu Mustafa Emre , Yildirim Atila , Ayas Eyyup , Alyildiz Nese , Mungan Sevdegul Aydin , Fidan Evren 
Published: September 2023

Abstract
Introduction KRAS mutation is observed in up to 30% of non-small-cell lung cancer (NSCLC) cases and is corelated with a poor prognosis. In the cases with KRAS p.G12C mutation and first-line chemotherapy (± immunotherapy) resistance, a targeted drug option is available.
Objectives Our study aimed to examine the correlation between first-line chemotherapy agents and treatment response in patients with KRAS-mutated metastatic NSCLC.
Materials and Methods Retrospective database searches were performed on cases diagnosed with metastatic NSCLC at our center between January 2019 and December 2021 that were found to be KRAS mutation positive using the next-generation sequencing (NGS) approach. The cases were classified into five subgroups based on the chemotherapy regimens (platinum + gemcitabine, platinum + taxane, platinum + pemetrexed, platinum + vinorelbine, and others). The clinical and demographic data of 41 cases were analyzed retrospectively, and survival analyses were performed using the Kaplan–Meier method.
Results Thirty-seven of 41 patients (90.2%) were males, and 27 (65.9%) had adenocarcinoma histology. The most prevalent mutation was KRAS G12C, with 12 cases (29.2%), followed by KRAS G12V, with 9 cases (21.9%). Other mutations were as follows: KRAS G12D 4 (9%), KRAS G13C 3 (7.3%), KRAS G12A 2 (4.8%), KRAS G12R 2 (4.8%), KRAS Q61H 2 (4.8%), KRAS Q61L 2 (4.8%), KRAS V14I 2 (4.8%), KRAS A146T 1 (2.4%), KRAS G13G 1 (2.4%), and KRAS G1C 1 (2.4%). The median progression-free survival (mPFS) for all groups was 4.6 months (95% confidence interval [CI]: 2.7-6.5), and there were no statistically significant differences between the groups (p = 0.121). The median overall survival (mOS) for all groups was 9.3 months (95% CI: 3.8–14.5), and there were no statistically significant differences between the groups (p = 0.805).
Conclusions OS and PFS analyses showed no differences between platinum + taxane, platin + pemetrexed, platinum + gemcitabine, and platin + vinorelbine used in first-line treatments for KRAS mutant NSCLC cases. We believe that patient-specific characteristics may be a determining factor in selecting chemotherapy for this patient population.
Reliability enhancement of InGaAs/AlGaAs quantum-well lasers on on-axis Si (001) substrate
Authors: Jiang Chen , Liu Hao , Liu Zhuoliang , Ren Xiaomin , Ma Bojie , Wang Jun , Li Jian , Liu Shuaicheng , Lin Jiacheng , Liu Kai , Wei Xin , Wang Qi 
Published: September 2023

The enhancement of the reliability of the silicon-based III–V quantum well lasers, especially of those on an on-axis Si (001) substrate, is of great importance now a days for the development of Si-based photonic and even optoelectronic integrated circuits and is really quite challenging. As an experimental advancement, mainly by inserting a pair of InAlAs strained layers separately into the upper and lower AlGaAs cladding layers to effectively prevent the formation of the in-plane gliding misfit-dislocations within the boundary planes of the active region, the longest room-temperature and continuous-wave lifetime of the InGaAs/AlGaAs quantum well lasers on an on-axis Si (001) substrate with a cavity length of 1500 µm and a ridge width of 20 µm has been prolonged from a very initial record of ∼90 s to the present length longer than 31 min. While, the highest continuous-wave operation temperature of another one with a cavity length of 1000 µm and a ridge width of 10 µm has been shown as 103 °C with an extracted characteristic temperature of 152.7 K, further enhancement of the device reliability is still expected and would mainly depend on the level of the threading-dislocation-density reduction in the GaAs/Si virtual substrate.
Organic-inorganic halide perovskites for memristors
Authors: Qammar Memoona , Zou Bosen , Halpert Jonathan E. 
Published: September 2023

Abstract
Organic-inorganic halides perovskites (OHPs) have drawn the attention of many researchers owing to their astonishing and unique optoelectronic properties. They have been extensively used for photovoltaic applications, achieving higher than 26% power conversion efficiency to date. These materials have potential to be deployed for many other applications beyond photovoltaics like photodetectors, sensors, light-emitting diodes (LEDs), and resistors. To address the looming challenge of Moore's law and the Von Neumann bottleneck, many new technologies regarding the computation of architectures and storage of information are being extensively researched. Since the discovery of the memristor as a fourth component of the circuit, many materials are explored for memristive applications. Lately, researchers have advanced the exploration of OHPs for memristive applications. These materials possess promising memristive properties and various kinds of halide perovskites have been used for different applications that are not only limited to data storage but expand towards artificial synapses, and neuromorphic computing. Herein we summarize the recent advancements of OHPs for memristive applications, their unique electronic properties, fabrication of materials, and current progress in this field with some future perspectives and outlooks.