bluuebunny/crossref_metadata_2025_split huggingface dataset:
Piloting HealthScore: Feasibility and acceptability of a clinically integrated health coaching program for people living with cancer
Authors: Wood William A. , Bailey Carly , Castrogivanni Brianna , Mehedint Diana , Bryant Ashley Leak , Lavin Kyle , Tan Xianming , Richardson Jaime , Qian Yiqing , Tan Kelly R. , Kent Erin E. 
Published: January 2023

AbstractBackgroundCancer supportive care interventions often have limited generalizability, goal misalignment, and high costs. We developed and piloted a health coaching intervention, UNC HealthScore, in patients undergoing cancer treatment (ClinicalTrials.gov identifier NCT04923997). We present feasibility, acceptability, and preliminary outcome data.MethodsHealthScore is a six‐month, theory‐based, multicomponent intervention delivered through participant‐driven coaching sessions. For the pilot study, participants were provided a Fitbit, responded to weekly symptom and physical function digital surveys, and met with a health coach weekly to develop and monitor goals. Coaching notes were discussed in weekly interdisciplinary team meetings and provided back to the treating oncology team. Symptom alerts were monitored and triaged through a study resource nurse to relevant supportive care services. Feasibility was determined based on intervention enrollment and completion. Acceptability was based on satisfaction with coaching and Fitbit‐wearing and was informed by semistructured exit interviews. Outcomes evaluated for signs of improvement included several PROMIS (Patient‐Reported Outcomes Measurement Information System) measures, including the primary intervention target, physical function.ResultsFrom May 2020 to March 2022, 50 participants completed the single‐arm pilot. Feasibility was high: 66% enrolled and 71% completed the full intervention. Participants reported an average of 4.8 and 4.7 (out of 5) on the acceptability of coaching calls and using the Fitbit, respectively. Physical function scores rose 3.1 points (SE = 1.1) from baseline to 3 months, and 4.3 (SE = 1.0) from baseline to 6 months, above established minimal clinically important difference (MCID). Improvements above MCID were also evident in anxiety and depression, and smaller improvements were demonstrated for emotional support, social isolation, cognitive function, symptom burden, and self‐efficacy.DiscussionHealthScore shows feasibility, acceptability, and promising preliminary outcomes. Randomized studies are underway to determine the efficacy of preserving physical function in patients with advanced cancer.
Child protection pathways for newborn infants: A multi‐disciplinary retrospective chart review of an Irish maternity hospital’s records
Authors: Jenkins Elinor , Corbett Maria , Breen Anna , O'Brien Kerri , Cooney Caoimhe , McGrath Robert , Flynn Emma , White Martin 
Published: January 2023

AbstractIn Ireland, little is known about mothers and infants where child welfare and protection concerns arise during the perinatal period. This study explores, for the first time, perinatal child protection. A retrospective audit was carried out of a large maternity hospital's medical social work, neonatal and psychiatric files for a five‐year period from 2016 to 2020. The study identified 99 children, born to 86 mothers, who were either subject to a child protection conference; placed for adoption; discharged to someone other than the mother; or discharged home under supervision. The study found that two‐thirds of the children were discharged to their mother's care. When compared to national data, the health indicators for this cohort of mothers and children painted a grim picture. The maternal profiles identified high prevalence of mental health and addiction difficulties and domestic violence. The study found evidence of supports provided to the mothers to enable them to care for their infants while they remained in the hospital and during an initial discharge from hospital. However, a significant number of the mothers were not caring for their children when viewed across a longer time frame. Dedicated multi‐disciplinary clinics and improved data systems were identified as of importance.
Giving HOPE and minimising trauma: An intervention to support women who are separated from their babies at birth due to safeguarding concerns
Authors: Mason Claire , Ward Harriet , Broadhurst Karen 
Published: January 2023

AbstractWhatever the circumstances, the separation of infants from their mothers at birth is a traumatic experience for all concerned. The paper reports on a study designed to improve practice in this highly sensitive area. An analysis of data collected through semi‐structured interviews with 38 mothers who had experienced removal at birth identified four common themes: isolation and unacknowledged support needs; shame, stigma and the failure of others to acknowledge their maternal identity; acute trauma, immediate downturn and disenfranchised grief following infant removal; and strategies to mitigate their pain and grief. These last themes included the use of artefacts both as transitional objects to help mothers come to terms with the permanent loss of a baby, and as a means of keeping maternal identity alive and connecting with an infant who might eventually return home. In response to these findings, and in collaboration with a group of women with lived experience, HOPE boxes were designed to ameliorate the trauma and psychological burden borne by women in this situation. The contents of the boxes have been chosen to reflect the changing experiences of the women's journeys but also the range of possible potential outcomes. The intervention has considerable potential to minimise the trauma of this painful experience.
Effects of burdock root flour (Arctium lappa) on yeast fermentation power, microstructure, quality, and storability of bread made with partial replacement of wheat flour
Authors: Mondal Shakti Chandra , Eun Jong‐Bang 
Published: January 2023

AbstractBackground and ObjectivesThe nutrient content, antioxidant status, yeast fermentation ability, and sensory aspects of baked goods may be impacted by the inclusion of different forms of fiber in the formulation. The main goal of this study was to assess the effects of adding burdock root flour (BRF) as an ingredient in bread baking. Therefore, BRF was used in place of 3%, 6%, and 9% of wheat flour to test its effect on yeast fermentation and the structure and quality of bread.FindingsA correlation between fermentation time and dough volume was established during the partial addition of BRF to replace wheat flour. The addition of BRF negatively influenced the gas generated during fermentation (ranging from 6.74 to 4.65 ml/min), reducing the final bread volume. The specific volume of bread was demonstrated to be reduced by over 50% as a result of the inclusion of BRF. However, there was a large rise in the protein, minerals, and antioxidant capacity of the bread with added BRF owing to BRF's high polyphenol and flavonoid contents. As the BRF concentration in the bread increased, the values of the crusts' lightness (L*), greenness/redness (a*), and yellowness/blueness (b*) decreased, while the values of the a* and b* increased in the crumb. Scanning electron microscope analysis revealed a denser bread structure due to the addition of BRF. Furthermore, bread with added BRF became harder, chewier, gummy, and springier while losing its crumb cohesion. However, cohesiveness exhibited the opposite tendency to hardness during bread storage.ConclusionsSubstituting BRF in place of wheat flour significantly increased the nutritional quality, total polyphenol, and total flavonoid levels (p < .05). Based on the sensory evaluation, bread with 3% BRF substitution had similar overall acceptability compared with the control bread samples.Significance and NoveltyThe study's results may support using BRF as a supplemental raw material for high‐quality bread making.
COVID‐19‐induced thrombotic microangiopathy: A great mimicker of thrombotic thrombocytopenic purpura (TTP)
Authors: Warnecke Brian , Kapoor Vidit , Wehbe Alexandra , Datta Paromita 
Published: January 2023

AbstractWe present a unique case of a 68‐year‐old male who was diagnosed with COVID‐19. His hospital course was complicated by widespread thrombosis, renal failure, and thrombocytopenia. Thrombotic thrombocytopenic purpura was initially suspected, yet plasma exchange and steroids did not improve his disease. Ultimately, he was diagnosed with COVID‐19‐induced thrombotic microangiopathy.
Adult‐onset still's disease and budd‐chiari syndrome: A case report
Authors: Hakamifard Atousa , Aria Amir , Momenzadeh Mahnaz 
Published: January 2023

AbstractAdult onset still's disease (AOSD) is a rare autoinflammatory disease displaying with a wide range of non‐specific symptoms and budd‐chiari syndrome (BCS) is an uncommon disorder characterized by obstruction of hepatic venous outflow. We present the case of a young patient who presented with persistent fever, sore throat, elbow, hand fingers and knees arthralgia with abdominal pain. The patient's symptoms had started 7 days before the referral. Imaging and laboratory data led to the diagnosis of BCS in the context of AOSD. The patient treated with corticosteroid in combination of warfarin with favorable outcome and complete improvement of signs and symptoms. We came to this conclusion AOSD complicated with BCS is a rare but potentially life‐threatening entity. Clinicians should be aware of this complication.
Adult‐size interface during non‐invasive ventilation for a child with pediatric acute respiratory distress syndrome: Maintaining principle on a different population
Authors: Alfraij Abdulla , Alajmi Mohsen 
Published: January 2023

AbstractAcute respiratory failure is a common pediatric condition requiring respiratory support invasively or non‐invasively. Limited access to proper size interface in pediatrics causes a significant drawback from using non‐invasive ventilation. We report a successful use of an adult‐size nasal interface by fitting a child's oro‐nasal area to ventilate him non‐invasively.
Albright hereditary osteodystrophy: Delay in the diagnosis of a rare disorder due to restricted medical services
Authors: Noor Sahar , Hakimzada Nasrin , Safi Nijatullah , Alikozai Sultan Mahmood , Rasooli Abdul Jamil , Jalalzai Tooryalai , Siddiqui Qais , Sestani Ahmad Jalil , Nasir Najla , Noor Sarah , Haidary Ahmed Maseh , Khalid Saifullah 
Published: January 2023

AbstractA teenage Afghan girl presented with seizure. Clinical features and laboratory investigations revealed elevated serum parathormone, high phosphate levels with low serum calcium. In third‐world countries, diagnosis of rare disorders, such as Albright hereditary osteodystrophy (AHO), can usually be delayed due to scarcity of standard medical and diagnostic services.
Intraosseous lipoma of Calcaneum: A rare incidental finding
Authors: Lamichhane Bishesh , Lamichhane Saral , Shah Roshan , Yadav Mamata , Pant Sujata 
Published: January 2023

AbstractIntraosseous lipoma is a rare benign lesion of bone. We present a case of an intraosseous lipoma of the calcaneum detected as an incidental finding, as a well‐delineated osteolytic lesion with the central area of calcification, on plain radiography. Diagnosis can be done with a computed tomography scan and/or magnetic resonance imaging.
Left ventricular pseudoaneurysmectomy in patient without hemodynamic instability: A case report
Authors: Bakhutashvili Zviad , Janelidze Lia , Beria Kakhaber , Bakashvili Nana , Kuridze Nika 
Published: January 2023

AbstractWe present a case of a 66‐year‐old male with a history of two previous diagnoses of myocardial infarction, followed by drug‐eluting stent implantation. During the check‐up, he complained of dyspnea, fatigue, and dizziness. Echocardiography revealed a massive left ventricular pseudoaneurysm (LVP). According to the patient's clinical manifestations and radiologic data, urgent surgical intervention was performed. Postoperatively, several complications appeared, which were managed successfully. The patient was discharged in stable condition. This is an interesting case of massive LVP without hemodynamic instability.
Tuberculous meningitis
Authors: Fukushima Shinnosuke , Ocho Kazuki , Fujita Koji , Hagiya Hideharu , Otsuka Fumio 
Published: January 2023

AbstractTuberculous meningitis is possibly complicated with multiple cerebral infarctions and basal meningitis, and the mortality and neurological prognosis is reportedly poor. This case suggested that clinicians should consider tuberculous meningitis as a differential diagnosis of patients with disturbed consciousness in an aging country Japan.
Primary aortoduodenal fistula presenting as a rare cause of upper gastrointestinal bleeding
Authors: Rejab Haitham , Fendri Sami , Bouzid Ahmed , Dammak Ayman , Ben Jemaa Hela , Trigui Ayman , Boujelben Salah 
Published: January 2023

AbstractPrimary aortoduodenal fistula (ADF) is a serious life‐threatening condition. Unlike secondary ADF which occurs in patients who had previous aortic prosthetic reconstruction, primary ADF is uncommon. Its diagnosis is often unsuspected until surgery or postmortem. We report a rare case of primary ADF presenting as massive gastrointestinal bleeding.
High‐Content Hydroxyapatite Carbon Composites for the Electrochemical Detection of Heavy Metal Cations in Water
Authors: Magni Mirko , Sironi Davide , Ferri Michele , Trasatti Stefano , Campisi Sebastiano , Gervasini Antonella , Papacchini Maddalena , Cristiani Pierangela 
Published: January 2023

AbstractThe great performance of nanostructured hydroxyapatite (Hap) in adsorbing heavy metal cations with the good electrical conductivity of high‐surface carbon materials was here combined for the crafting of high‐content hydroxyapatite electrodes (Hap 84–96 wt.%) endowed with the synergistic capability of detection and adsorption of heavy metal cations by water solutions. To improve the sustainability of the sensor, a mesoporous carbon (derivable by bio‐waste) was selected as scaffold for depositing Hap by simply co‐precipitation. The composite with 92 wt.% of Hap, which exhibited ca. 1 : 1 ratio between the exposed area of Hap and carbon (by Brunauer‐Emmett‐Teller method), invariably showed an average stripping oxidation peak intensity of ca. 250 μA cm−2 and 150 μA cm−2 for a 50 μM Pb2+ and Cu2+ solution, respectively. Control experiments showed that the above sensor outperformed the sensibility of two low‐content Hap electrodes (4 and 8 wt.%), representative of the best performing Hap‐carbon composites available in literature.
Electrocatalytic Aldehyde Oxidation by a Tungsten Dependent Aldehyde Oxidoreductase from Aromatoleum Aromaticum
Authors: Kalimuthu Palraj , Hege Dominik , Winiarska Agnieszka , Gemmecker Yvonne , Szaleniec Maciej , Heider Johann , Bernhardt Paul V. 
Published: January 2023

AbstractIn contrast to their molybdenum dependent relatives, tungsten enzymes operate at significantly lower redox potentials, and in some cases they can carry out reversible redox transformations of their substrates and products. Still, the electrochemical properties of W enzymes have received much less attention than their Mo relatives. Herein we analyse the tungsten enzyme aldehyde oxidoreductase (AOR) from the mesophilic bacterium Aromatoleum aromaticum which has been immobilised on a glassy carbon working electrode. This generates a functional system that electrochemically oxidises a wide variety of aromatic and aliphatic aldehydes in the presence of the electron transfer mediators benzyl viologen, methylene blue or dichlorophenol indophenol. Simulation of the cyclic voltammetry has enabled a thorough kinetic analysis of the system, which reveals that methylene blue acts as a two‐electron acceptor. In contrast, the other two mediators act as single electron oxidants. The different electrochemical driving forces imparted by these mediators also lead to significantly different outer sphere electron transfer rates with AOR. This work shows that electrocatalytic aldehyde oxidation can be achieved at a low applied electrochemical potential leading to an extremely energy efficient catalytic process.
Syntheses and Biofilm Reducing Effects of l‐Dopa‐Derived Analogues of the Fungal Macrocidins A and Z
Authors: Pezolt Christine , Karau Annika , Schobert Rainer , Schrey Hedda 
Published: January 2023

AbstractFour analogues of the fungal metabolites macrocidin A and Z, featuring [13]para‐ or [13]metacyclophanes, were synthesised from fully and orthogonally protected l‐dopa instead of l‐tyrosine. They were tested for antibiotic activities and for effects on the growth and persistence of microbial biofilms. Tentative structure‐activity relationships and distinct differences when compared with the natural lead compounds were identified.
Catalyst‐Free Thia‐Michael Addition to α‐Trifluoromethylacrylates for 3D Network Synthesis
Authors: Berne Dimitri , Lemouzy Sébastien , Guiffrey Pascale , Caillol Sylvain , Ladmiral Vincent , Manoury Eric , Poli Rinaldo , Leclerc Eric 
Published: January 2023

AbstractThia‐Michael additions (1,4‐additions of a thiol to a Michael acceptor) are generally catalyzed by an external Brønsted or Lewis base. A spontaneous (uncatalyzed) Michael addition of thiols to α‐trifluoromethyl acrylates is described, as well as its application to the very efficient preparation of a thermoset. A thorough mechanistic investigation, based on an experimental kinetic study and on DFT calculations, is presented for the addition of arene‐ and alkanethiols to tert‐butyl trifluoromethyl acrylate in polar aprotic solvents, unveiling a probable solvent‐assisted proton transfer in the rate‐determining step and a considerable lowering of the energy barrier induced by the CF3 group.
The Prominence of Facilitator π‐Holes: The Classic N←N Pnictogen Bonding in Nitrobenzene‐Ammonia Dimer with its Structural Elucidation and Experimental Characterization at Low Temperatures
Authors: Chandra Swaroop , Mahapatra Nandalal , Ramanathan N. , Sundararajan K. 
Published: January 2023

AbstractThe nitrogen of nitro group is a paradigmatic pnictogen due the presence of a π‐hole and a number of studies have been performed recently on prototypical nitromethane (NM). Homodimers and heterodimers of NM are sustained by π‐hole driven pnictogen bonds hosted by nitrogen. To understand the effect of substitution on this π‐hole and thus the pnictogen bond, heterodimers of nitrobenzene (NB; phenyl substitution in place of methyl) with ammonia (AM) have been probed, as a test case, using matrix isolation infrared spectroscopy and ab initio computations. Of the four structures optimized on the potential energy surface the energetically dominant global minimum, stabilized by π‐hole driven O=N←N pnictogen bonding with co‐operative N−H←O hydrogen bonding, was experimentally identified at low temperatures. A comparison of the pnictogen bonding of NB‐AM dimers with NM counterpart (NM‐AM dimers) divulged the dominance of electrostatic origin of pnictogen bonding in both the class of dimers. The reduced strength of pnictogen bonding in NB‐AM dimers in comparison to NM‐AM dimers was discerned, which has been established to be a consequence of the reduced electrostatic potential at the π‐hole of NB relative to that in NM. The strength of π‐hole driven pnictogen bond was directly correlated with the binding energy and the infrared shifts in the signature vibrational bands of the NB, NM and AM submolecules due to dimerization under matrix isolated conditions at low temperatures.
A Single‐dose, Two‐Period Crossover Bioequivalence Study Comparing Two Liraglutide Formulations in Healthy Chinese Subjects
Authors: Feng Shiyin , Cai Linrui , Wang Xiaoyan , Yu Qin , Cai Junjie , Hao Wenjing , Chen Zhuo , Su Xu , Du Chunfeng , Zou Qin , Guo Weiyi , Du Dan , Hu Feng , Li Fengshan , Liu Yan 
Published: January 2023

AbstractLiraglutide, a glucagon‐like peptide 1 receptor agonist, is indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes. The original liraglutide products are costly, which limits patient access to this therapeutic treatment. Herein, a biosimilar was developed that is highly similar to the reference drug in molecular structure and bioactivity, and is expected to have similar pharmacokinetic (PK) and safety profiles in clinical studies. This study aimed to primarily evaluate the bioequivalence of 2 liraglutide formulations and secondarily assess their safety in healthy Chinese subjects following a single‐dose subcutaneous injection. Thirty‐two healthy volunteers were recruited in this randomized, open‐label, single‐dose, 2‐period crossover bioequivalence study (ChiCTR2100043348). The geometric mean ratios (GMRs) of the test drug to the reference drug (T/R) and corresponding 90% confidence intervals (CIs) for maximum concentration (Cmax) and the area under the concentration–time curve from time 0 to the time of the last quantifiable concentration (AUC0–t) were estimated using a mixed‐effects model, and bioequivalence was determined to have been achieved if the 2‐sided 90%CI fell within the predefined range of 80%–125%. PK parameters were comparable between T and R, with GMRs of T/R for Cmax and AUC0–t being 105.7% and 107.7%, respectively, the 90%CI of which met the acceptance criteria for bioequivalence. We also observed a similar and favorable safety profile in the T and R arms, with adverse events being predominantly mild in severity and of gastrointestinal origin. Our findings indicate that the test drug is safe and well tolerated, bioequivalent to the reference drug, and warrants further testing in a phase III clinical trial.
First‐principles Density Functional Theory Elucidation of the Hydrogen Evolution Reaction on TM‐promoted TiC2 (TM=Fe, Co, Ni, Cu, Ru, Rh, Pd, Ag, Os, Ir, Pt, and Au)
Authors: Guo Hengquan , Gu Kang Sung , Geol Lee Seung 
Published: January 2023

AbstractSingle‐atom‐catalyst‐based systems have been attractive by virtue of their desirable catalytic performance. Herein, the possibility of the 15 transition‐metal (TM)‐promoted (TM=Fe, Co, Ni, Cu, Zn, Ru, Rh, Pd, Ag, Cd, Os, Ir, Pt, Au, and Hg) and their hydrogen evolution reaction (HER) performance were investigated on two‐dimensional titanium carbides (TiC2). It is found that the adsorption strength of TMs on TiC2 is stronger than that of TMs on γ‐graphyne and weaker than that of TMs on Ti3C2. Among the fifteen investigated catalysts, Ru−TiC2, Ag−TiC2, Ir−TiC2, Au−TiC2, and Fe−TiC2 exhibits overpotential of −0.18, −0.15, −0.18, −0.17, and −0.04 V, respectively. In addition, the Volmer‐Tafel step was preferred to the Volmer‐Heyrovsky step on Fe−TiC2. This work suggests that Fe−TiC2 is possibly a superior HER electrocatalyst.
Sustainable Polythioesters via Thio(no)lactones: Monomer Synthesis, Ring‐Opening Polymerization, End‐of‐Life Considerations, and Industrial Perspectives
Authors: Narmon An Sofie , van Slagmaat Christian A. M. R. , De Wildeman Stefaan M. A. , Dusselier Michiel 
Published: January 2023

AbstractAs the environmental effects of plastics are of ever greater concern, the industry is driven towards more sustainable polymers. Besides sustainability, our fast‐developing society imposes the need for highly versatile materials. Whereas aliphatic polyesters (PEs) are widely adopted and studied as next‐generation biobased and (bio)degradable materials, their sulfur‐containing analogs, polythioesters (PTEs), only recently gained attention. Nevertheless, the introduction of S atoms is known to often enhance thermal, mechanical, electrochemical, and optical properties, offering prospects for broad applicability. Furthermore, thanks to their thioester‐based backbone, PTEs are inherently susceptible to degradation, giving them a high sustainability potential. The key route to PTEs is through ring‐opening polymerization (ROP) of thio(no)lactones. This Review critically discusses the (potential) sustainability of the most relevant state‐of‐the‐art in every step from sulfur source to end‐of‐life treatment options of PTEs, obtained through ROP of thio(no)lactones. The benefits and drawbacks of PTEs versus PEs are highlighted, including their industrial perspective.