bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Japanese nationwide health datasets: association between lifestyle habits and prevalence of neuropathic pain and fibromyalgia with reference to dementia-related diseases and Parkinson’s disease
Authors: Nagakura Yukinori , Hayashi Maya , Kajioka Shunichi 
Published: July 2023

Abstract

Objectives
Chronic pain is defined as pain that persists or recurs for more than 3 months. This study focuses on neuropathic pain (NP) and fibromyalgia (FM) which are chronic pain states, and aims to identify lifestyle habits associated with their prevalence. Other neurological disorders are also analyzed as references.

Methods
Association between the variable referring to disease prevalence (number of claims for reimbursement of marker drugs) and the variable for lifestyle habits/health examination results (collected from insured individuals aged 40–74 years) was determined by analyzing Japanese nationwide datasets, which were collected in 2018 and aggregated by prefecture. Pregabalin, donepezil, and levodopa were used as marker drugs for the chronic pain states, dementia-related diseases (Alzheimer’s disease and Lewy body dementia) and Parkinson’s disease (PD), respectively. Pearson’s correlation analysis and multiple linear regression analysis were conducted.

Results
Variables showing correlation coefficient (|r|)>0.5 were put into the multiple linear regression. Exercise habits (ꞵ=−0.3182), smoking habits (0.3218), daily drinking (0.2683), and alanine aminotransferase>51 U/L (0.2309) were finally incorporated in the equation for pregabalin (R
2=0.7268). Walking speed (−0.4543) and daily drinking (0.5077) were incorporated in the equation for donepezil (R
2=0.5718).

Conclusions
The prevalence of chronic pain states is associated with lifestyle habits, just like the dementia-related diseases. Exercise in daily life is negatively associated with the prevalence of the chronic pain states, although excessive alcohol drinking, smoking, and high serum ALT are positively associated with it. The prevalence of PD seems less associated with lifestyle habits.
Active subspace-based performance analysis of supersonic through-flow fan rotor
Authors: Yang Jutao , Shen Yuxin , Ji Lucheng , Li Jiabin , Zhou Ling 
Published: July 2023

Abstract
This article delves into the intricate relationship between the modeling parameters of an axial supersonic through-flow fan (STFF) rotor and its performance based on an active subspace method. It considers the influence of the STFF rotor key parameters on its performance. Implementing the active subspace method generates cloud maps to visualize the performance of the STFF rotor. Moreover, this study investigates the correlation between Bezier curve variables for constructing blade angles and critical performance metrics, such as the total pressure ratio and isentropic efficiency. After a 50 % chord length, the Bezier control point parameters dominate the effect on the total pressure ratio with a linear relationship. This article provides comparative flow field analyses on the blade elements with different performances under three working conditions. Under the constraint of the blade chamber turning angle, there is a linear relationship between the upper and lower limits of the isentropic efficiency distribution and total pressure ratio. This study shows that the total pressure ratio, installation angle, and maximum deflection value are positively associated. Further analysis provides an empirical formula.
Cancer‐cell‐secreted extracellular vesicles target p53 to impair mitochondrial function in muscle
Authors: Ruan Xianhui , Cao Minghui , Yan Wei , Jones Ying Z , Gustafsson Åsa B , Patel Hemal H , Schenk Simon , Wang Shizhen Emily 
Published: July 2023

AbstractSkeletal muscle loss and weakness are associated with bad prognosis and poorer quality of life in cancer patients. Tumor‐derived factors have been implicated in muscle dysregulation by inducing cachexia and apoptosis. Here, we show that extracellular vesicles secreted by breast cancer cells impair mitochondrial homeostasis and function in skeletal muscle, leading to decreased mitochondrial content and energy production and increased oxidative stress. Mechanistically, miR‐122‐5p in cancer‐cell‐secreted EVs is transferred to myocytes, where it targets the tumor suppressor TP53 to decrease the expression of TP53 target genes involved in mitochondrial regulation, including Tfam, Pgc‐1α, Sco2, and 16S rRNA. Restoration of Tp53 in muscle abolishes mitochondrial myopathology in mice carrying breast tumors and partially rescues their impaired running capacity without significantly affecting muscle mass. We conclude that extracellular vesicles from breast cancer cells mediate skeletal muscle mitochondrial dysfunction in cancer and may contribute to muscle weakness in some cancer patients.
30-year Review of Ameloblastoma: A tertiary hospital-based study
Authors: Black Alan , Machete Motimedi , Motloba Pagollang 
Published: July 2023

Introduction
The clinical, histological and radiographic presentation of ameloblastoma is well described in literature. This odontogenic tumour commonly affect the mandible, locally aggressive and destructive resulting in disfigurement. It arises from dental tissues at various phases of tooth development. They are generally asymptomatic, slow growing, locally invasive and rarely malignant with a high recurrence rate.

Objective
To test the hypotheses that ameloblastomas were predominant in the mandible. among black Africans, male and the young.
Study Design
Retrospective review of ameloblastoma cases spanned between 1991 and 2022.
Methods
Data analysis was based on 185 histologically confirmed cases. Appropriate descriptive and inferential statistics were undertaken on, age, gender, clinical, radiographic and histological characteristics.
Results
The average age was 28.81 (14.53), ranging between 3-75 years. The overall male to female ratio stood at 1.18:1. Ameloblastomas were prevalent in the mandible 174(94.1%), diagnosed as conventional variant 155(83.7%) and acanthomatous subtype. Radiographically, the lesions appeared as multilocular 97(55.4%), radiolucent 100(54.1%) and expansile 129(67.7%). The average size of the lesions was 77.43 ± 33.83 mm, with a range of 184 mm.
Conclusion
Our results validate the hypothesis that ameloblastoma is highly prevalent among black Africans of younger age. The radiographic, clinical, and histological characteristics of ameloblastoma in our population are comparable to the vast literature.
Religious Moderation Values in The Local Wisdom of Reog Dadak Lar Pitik
Authors: Sari Ulfi Andrian , Nasith Ali , Azharotunnafi Azharotunnafi , Yasri Hayyun Lathifaty 
Published: July 2023

Reog art has become the identity of the Ponorogo district. Paguyuban Singo Mudo in Sidoharjo village, Ponorogo regency, is the only one that preserves the unique local wisdom of reog, namely reog dadak lar pitik. This reog was made because the community in Sidoharjo had difficulty getting peacock feathers and tiger skin as basic reog ingredients, so they were replaced with dadak lar pitik and civet skin. Then reog dadak lar pitik is believed to be a tradition to bring rain. This research aims to analyze the values of religious moderation in the local wisdom of reog dadak lar pitik. This research was conducted using a qualitative approach with ethnographic methods. The data collection tools were observation sheets, interview sheets, documentation, and Forum Group Discussion (FGD). The findings are first, preserving local culture can be seen in people who still uphold the reog dadak lar pitik performance as a means of bringing rain. Second, tolerance is seen in people who still respect the opinion of the belief that this reog can bring rain, even though many people no longer believe it. The third is the absence of conflict of belief, whether those who believe in the myth of reog dadak lar pitik can bring rain, because this reog was used as a means of da'wah. Fourth, patriotism is depicted in the characters of the reog actors who have a patriotic spirit. Kesenian reog menjadi identitas kabupaten Ponorogo. Paguyuban singo mudo di Desa Sidoharjo, kabupaten Ponorogo satu satunya yang melestarikan kearifan lokal reog yang unik yaitu reog dadak lar pitik. Reog dadak lar pitik dibuat karena masayarakat di Sidoharjo kesulitan mendapatkan bulu merak dan kulit harimau sebagai bahan dasar reog sehingga diganti dengan dadak lar pitik dan kulit musang. Kemuadian reog dadak lar pitik dipercaya sebagai tradisi untuk mendatangkan hujan. Tujuan penelitian ini untuk menganalissis nilai-nilai moderasi beragama dalam kearifan lokal reog dadak lar pitik. Penelitian ini dilaksanakan menggunakan pendekatan kualitatif dengan metode etnografi. Alat pengumpul data menggunakan lembar observasi, lembar wawancara, dokumentasi, dan Forum Group Discussion (FGD). Temuan penelitian ini pertama melestarikan budaya lokal tampak pada masyarakat yang masih memegang teguh pertunjukan reog dadak lar pitik sebagai sarana mendatangkan hujan. Ke dua, toleransi terlihat pada masyarakat yang tetap menghargai pendapat kepercayaan bahwa reog dadak lar pitik dapat mendatangkan hujan, walaupun banyak masyarakat yang sudah tidak percaya. Ke tiga perdamaian tampak dari tidak adanya konflik kepercayaan baik yang percaya dengan mitos reog dadak lar pitik dapat mendatangkan hujan atau tidak, karena reog dadak lar pitik dijadikan sarana dakwah. Ke empat, patriotisme tergambarkan pada tokoh-tokoh pemeran reog yang memiliki jiwa patriotisme.
Spontaneous Self-Affirmation and Student-Specific Stress: Relationships with Overlapping Constructs of Positive Self Regard During the COVID-19 Pandemic
Authors: Nicklin Anna , Morgan Jim 
Published: July 2023

Background: Student-specific stress is pervasive and impairs health and attainment. Experimentally induced self-affirmation can reduce stress, but little is known about the mechanisms underlying this effect, and the role of individual differences. The present study explores the relationship between spontaneous self-affirmation, student-specific stress, and overlapping constructs of positive self-regard during the COVID-19 pandemic.
Methods: The study investigated inter-relationships between spontaneous self-affirmation, student-specific perceived stress and potential covariates including self-esteem, self-integrity and habitual positive self-thought. University students (N = 151) aged 18 to 50 responded to an online questionnaire including the Spontaneous Self-Affirmation Measure, College Student Stress Scale, Rosenberg Self-Esteem Scale, Habitual Index of Positive Thinking and Self-Integrity Scale.
Results: Unexpectedly, regression analysis revealed that spontaneous self-affirmation was a positive predictor of student-specific stress, seemingly driven by relational affirmations. Self-esteem and habitual self-thought were negative predictors of student-specific stress, whilst self-integrity was not a predictor.
Conclusions: Habitual positive self-thought may offer a sustainable solution to student-specific stress, but spontaneous self-affirmation does not. A reduction in defensive responses, elicitation of negative emotions, or use of conditional relationships in relational affirmation
Sexually Transmitted Infections in Pre-Exposure Prophylaxis Patients
Authors: Sleeman Nicholas , Hoban Carol , Koutoubi Samer 
Published: July 2023

Background and Objective: Pre-exposure prophylaxis (PrEP) effectively prevents the spread of the human immunodeficiency virus (HIV). HIV is a disease primarily contracted by men who have sex with men or the sharing of needles, syringes, and other drug injection equipment. However, there is some disparity over the thought that PrEP patients have a disproportionate incidence of sexually transmitted infections (STIs) compared with non-PrEP patients. This study aims to clarify the disparity and identify if PrEP patients have a higher incidence of STIs.
Methods: A survey of 143 respondents was conducted on STI incidence, risk factors, and abstinence from May 13, 2022, to June 20, 2022. The results were analyzed in Statistical Package for the Social Sciences (SPSS V28.0.0.0). SPSS was used to analyze the descriptive statistics associated with STI data obtained from the Naval Medical Readiness and Training Command, Camp Lejeune, Community Health Clinic Patient and Laboratory Tracker.
Results: This study found a higher incidence of STIs among PrEP patients than non-PrEP patients and a statistical significance (p = 0.010) between the number of partners a person had sex with over the past year and the lifetime incidence of STIs. Portions of the data in the linear regression were used to calculate the significance and can be used as a predictor of STIs based on the number of partners a person has. This can help patients within this community understand their actual risk of contracting an STI based on a potential risk factor.
Conclusion and Implications for Translation: This study found a higher incidence of STIs among PrEP patients than non-PrEP patients. Additionally, the study can help public health professionals understand the risks associated with military patients who take PrEP and target specific risk factors that influence the disparity in the incidence of STIs. Future studies may use survey data from this study to understand the implications of other risk factors and their association with STIs. Public health professionals can also use these data to develop a predictive index for many risk factors. A predictive index on STI risk is an extremely valuable tool as it allows users to view their risk of obtaining an STI.

Copyright © 2023 Sleeman and Hoban. Published by Global Health and Education Projects, Inc.This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
Improvements in Drilling Fluid Rheology Predictions Using Rotational Viscometer
Authors: Costa Camila M. , Varges Priscilla R. , Naccache Monica F. 
Published: July 2023

Summary
The success of an oilwell drilling operation is directly associated with the correct formulation of drilling fluids and their rheological measurements. The goal of this study is to investigate the usage of a Fann 35A viscometer and the methodology for rheological characterization of drilling fluids by comparison with the use of a rotational rheometer. Flow curves and gel strength tests were performed considering classic measurement artifacts such as apparent wall slip, secondary flows, steady-state (SS) regime, and inertial effects, among others. In addition, a study of the relationship between pressure drop and flow rate in a tube and in an annular space was carried out to investigate the influence of the viscosity function and of the rheological properties on the design of pipelines and the correct sizing of pumps. Use of American Petroleum Institute (API) equations and curve fitting were explored as potential choices for viscosity functions. The results indicate that the use of API equation predictions can compromise the effectiveness of the drilling process, while the choice of an adequate viscosity function is essential for the correct sizing of pumps. The gel strength was evaluated in the viscometer and presented divergent results from those obtained in the rheometer. Furthermore, a grooved geometry was developed for the viscometer to avoid the effects of apparent slip at low shear rates. Some recommendations are made based on the results obtained, which lead to better accuracy in the rheological results of drilling fluids and, consequently, better performance of some functions assigned to it. The proposed improvements and methodologies proved to be promising, although in some cases the cost-benefit remained unchanged.
Parkinson’s disease-related lncRNA PINK1-AS advances glioma oncogenesis by activating IPO5-RAS signaling pathway
Authors: Sun Jinxing , Li Zhenke , Wang Xu , Jia Junheng , Wu Qianqian , Zhang Chao , Li Weiguo 
Published: July 2023

Abstract
Background: Epidemiological studies have demonstrated a higher incidence of gliomas in patients with Parkinson's disease. However, the underlying molecular mechanisms remain unclear, and insights into why and how patients with Parkinson's disease are susceptible to gliomas are essential for advancing novel therapeutic approaches for both diseases.
Methods: The Chinese Glioma Genome Atlas (CGGA) database was used to screen Parkinson’s disease-related genes associated with glioma prognosis. The expression of the lncRNA PINK1-AS in the brain tissue of patients with Parkinson’s diseaseand glioma tissues and cells was characterized by quantitative reverse transcription polymerase chain reaction. The efficacy of PINK1-AS knockdown in gliomas was evaluated by assessing cell proliferation, migration, cell cycles, and experimental xenografts. To establish the relationship between the PINK1-AS, miR-200a-3p, and IPO5 genes, RNA immunoprecipitation, RNA probe pull-down, luciferase reporter, and fluorescence in situ hybridization assays were performed.
Results: PINK1-AS expression was anomalously elevated in brain tissue of patients with Parkinson’s disease, glioma tissues, and cell lines compared to normal brain tissue, and the overall survival time was reduced in patients with glioma with high PINK1-AS expression. PINK1-AS knockdown remarkably suppressed glioma malignant phenotypes, including cell promotion, metastasis, and aggression in vitro and xenograft tumor generation in vivo. Furthermore, PINK1-AS may serve as a pool for miR-200a-3p, thereby de-repressing IPO5 and activating the RAS signaling pathway.
Conclusions: PINK1-AS, highly expressed in both Parkinson's disease and glioma, regulates IPO5 expression by downregulating miR-200a-3p and activating the RAS signaling pathway.
Yield Strength-Plasticity Trade-off and Uncertainty Quantification for Machine-learning-based Design of Refractory High-Entropy Alloys
Authors: Giles Stephen , Shortt Hugh , Liaw Peter , Sengupta Debasis 
Published: July 2023

Abstract
Refractory high-entropy alloys (RHEAs) are of prime interest for their potential use as high-temperature materials in next-generation gas turbine engines. Improving the strength-plasticity trade-off has been a grand challenge for RHEAs due to the vast composition search space and non-availability of reliable models. In this paper, we have developed a machine learning-based plasticity model and yield strength model in order to define criteria for the yield strength-plasticity trade-off. A robust probabilistic-based uncertainty quantification is performed to identify confidence in predictions. Model descriptors are also analyzed through a state-of-the-art model explainability technique. Our analysis not only is consistent with known physics, but also provides new insights for identifying critical descriptors dictating the strength-plasticity trade-off. This can be used as a guideline to discover new compositions with desired properties. Finally, model predictions are validated through processing and characterization of two new RHEA compositions.
Unmanipulated haploidentical hematopoietic stem cell transplantation for mixed phenotype acute leukemia: a single center study
Authors: Huang Junbin , Feng Bo , Cheng Yifei , Xu Lanping , Zhang Xiao-hui , Huang Xiao-Jun , Wang Yu 
Published: July 2023

Abstract
Mixed-phenotype acute leukemia (MPAL), which is categorized as a rare subtype of acute leukemia with a generally dismal prognosis. Hemopoietic stem cell transplantation (HSCT) is traditionally considered a curative treatment for MPAL. Thirty-three MPAL patients undergoing HSCT at the Peking University Institute of Hematology, Peking University People’s Hospital (Beijing, China) between December 2017 and April 2022 were enrolled in this study. The 2-year overall survival (OS) rate was 84.4% (95% confidence interval [95% CI], 69.9–98.9%), and the event-free survival (EFS) rate was 86.3% (95% CI, 73.8–98.8%) in MPAL patients undergoing HSCT in first complete remission (CR1). The median time to relapse after HSCT was 7.2 months (range: 0.8–12 months). The 2-year cumulative incidence of relapse (CIR) was 13.7% (95% CI, 4.2–28.9%). No patients died due to non-relapsed mortality (NRM) events. This study suggested that haplo-HSCT is a feasible and safe strategy for patients with MPAL patients in CR1. The outcomes were promising; however, they need to be confirmed by further research.
A rapid, efficient and cost-effective DNA isolation protocol for various herbal products which is appropriate for different downstream genomics applications
Authors: Ibrahim Munir , Detroja Asmita , BIshoyi ASHOK KUMAR 
Published: July 2023

Abstract

Medicinal plants have been used for the treatment of diseases and its demand is expanding in both developed and developing countries. The extensive consumption to meet demand:supply ratio exerts a heavy strain on the existing resources. This subsequently led to adulteration and substitution. The DNA-based method is the most widely adopted for the determination of adulteration in herbal products. Quality DNA extraction is regarded as the prerequisite for the application of DNA-based techniques in herbal plant authentication. Various protocols for DNA isolation could only be applied to a small number of species and were often expensive and time-consuming. Furthermore, herbal products undergo various conditions and are mixed with different substances, these factors affect the integrity of the DNA making it difficult to isolate. In this study, a simple, cost-effective and rapid CTAB-optimized DNA extraction protocol was developed which successfully isolated quality DNA from different samples of medicinal plants and their respective adulterants without using liquid nitrogen. Quality DNA was also isolated from different herbal products of reputed companies. The protocol was also validated in different herbarium samples and quality DNA has been obtained. DNA quality of both plants and herbal drugs was measured by A260/A280 ranging between 1.3–1.8. Thus, the developed protocol can be adapted to medicinal plants and herbal drugs quality DNA isolation and authentication as well as herbarium samples for molecular identifications. The isolated DNA was found to have suitable quality and sufficient quantity for ISSR-PCR, SCoT-PCR and restriction digestion reaction, advocating the protocol is best suitable for different genomics downstream applications.