bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of a program on home environmental management for fall prevention in older adults, lower northern Thailand
Authors: author Archin Songthap (Corresponding , Suphunnakul Pattama , Rakprasit Jutarat 
Published: April 2023

Abstract

This quasi-experimental research proposed to assess the effectiveness of a program on home environmental management for fall prevention in older adults, lower northern Thailand. Eighty samples were purposively selected and classified into two groups, experimental and control groups. A questionnaire was employed for data collection. The results indicated that after intervention, knowledge about home environmental management, social support, home environmental management, and proportion of falls in the experimental group were significantly different from before intervention and the control group. The program on home environmental management was effective to prevent falls in older adults. Therefore, healthcare providers, caregivers, village health volunteers, and relatives of the older adults should apply this program as a guideline to prevent falls and its consequence in the target group.
Plasma metabolism-related biomarkers enable non-invasive precision detection and individualized treatment in metastatic colorectal cancer
Authors: Shan Junqi , Zhao Ningning , Zhou Changchun , You Bowen , Yao Yao , Sun Yanlai 
Published: April 2023

Abstract
Colorectal cancer (CRC) is one of the most deadly malignancies worldwide, especially metastatic CRC (mCRC), whose diagnosis and therapy are limited. Here, the targeted metabolomes of patients with CRC and mCRC were analyzed to explore new biomarkers and treatment strategies. First, plasma was collected from patients with CRC (n = 50) and mCRC (n = 50). Serum metabolites of amino acids, bile acids, and fatty acids were detected by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Subsequently, 60 CRC and mCRC were randomly selected as the training set. A total of 27 amino acids, nine bile acids, and 16 amino acids were detected, among which 13 metabolites were significantly different. KEGG functional analysis showed that these differential metabolites play an essential role in the metabolism of fatty and bile acids. ROC analysis showed that CRC and mCRC could be well discriminated by 13 different metabolic indices, among which the sensitivity and specificity of the single index C18:2 were 0.833 and 0.800. To identify these markers, 40 CRC and mCRC patients were used as validation sets. The identification results of GCA, C17:0, and C18:2 were consistent with previous results. The AUC of GCA, C17:0, combined with C18:2, can reach 0.86, much higher than the traditional index CEA (0.70) and CA19.9 (0.80).Furthermore, Pearson analysis showed a significant correlation between GCA and CA19.9. Twenty-five mCRC patients were selected, and the AUC of GCA, CEA, and CA19.9 were 0.74, 0.74, and 0.70, respectively. In addition, the AUC of GCA and CEA combined with CA19.9 was significantly increased to 0.87. Taken together, our study showed that GCA, C17:0, in combination with C18:2, is superior to the clinical classic in differentiating CRC and mCRC. At the same time, GCA, in combination with CEA and CA19.9, can significantly improve the diagnosis of mCRC with liver metastases. This study is expected to provide new indicators for the diagnosis of mCRC and new strategies for the treatment of mCRC.
The Pass-Through of Temporary VAT Rate Cuts: Evidence from German Supermarket Retail
Authors: Fuest Clemens , Neumeier Florian , Stöhlker Daniel 
Published: April 2023

Abstract
We study the price effects of a temporary VAT reduction in Germany using a web-scraped data set of daily prices of more than 60 000 supermarket products. For causal identification , we compare the development of German prices to those in Austria. We find that the reduction of VAT rates led to a price decrease of 1.3%, implying that 70% of the tax cut were passed on to consumers. Moreover, the pass-through is higher for vertically integrated products (private label) than for independent brands. This is consistent with menu cost theories and theories predicting that price markups act as a buffer for cost shocks.
JEL Classification: E31, H22, H25.
Electromagnetic shielding and fire-retardant wood obtained by in situ aniline polymerization
Authors: Ba Zhichen , Liang Daxin , Xiao Zefang , Wang Yonggui , Wang Haigang , Xie Yanjun 
Published: April 2023

Abstract
In living spaces where wood has been used as a construction and decorative material, reducing the electromagnetic pollution and fire risk is important. Herein, wood was treated in situ with aniline, and the effects of the treatment on its electromagnetic shielding and fire retardant performance were investigated. The in situ polymerization and deposition of polyaniline particles in the wood cell walls induced the treated wood with enhanced conductivity with porous wood structures, which could improve the microwave absorption. The results indicated that the electromagnetic shielding efficiency increases with the decrease of wood density and the increase of porosity, and the specific electromagnetic shielding efficiency up to 65.8 dB cm-3 g-1 on the cross sections of treated wood. Furthermore, the total heat release and smoke production decreased by 43.6% and 64.2%, respectively. The wood char mass increased by 53.9%. The results demonstrated that polyaniline-treated wood with bifunctional features could serve as a promising candidate in this field.
Analysis of SOX gene family expression and prognostic significance in lung adenocarcinoma based on tumor databases
Authors: Chen Qingquan , Hu Yiming , Lu Haibin , Hu Jiayi , Huang Zhimin , Shi Jianfeng , Zeng Yifu , Li Jiaxin , Zhang Yixiang , Zhu Yong 
Published: April 2023

Abstract

Objective To analyze the expression of the SOX gene family in lung adenocarcinoma and its impact on the prognosis of lung adenocarcinoma patients using tumor databases. Methods The cBioPortal database was used to retrieve and analyze the mutation frequencies and variants of 10 genes in the SOX gene family in lung adenocarcinoma tissues. Using clinical information from the Kaplan-Meier plotter database, the potential prognostic values of 10 genes in the SOX gene family in lung adenocarcinoma patients were further explored. The UALCAN database and TCGA database were used to obtain the expression of methylation of SOX gene family members and compare the mRNA expression of 10 genes in lung adenocarcinoma tissues and paracancerous tissues, respectively. The miRCancer database was intersected with miRTarBase, ENCORI, and miRWalk databases to find the lung adenocarcinoma-related miRNAs that regulate the SOX gene family. Results Most members in the SOX gene family had expansion mutation, but SOX15 had a deletion mutation. The expressions of SOX8 and SOX17 genes were upregulated in lung adenocarcinoma patients (HR < 1, log-rank P < 0.05), which was beneficial to their prognosis. In addition, SOX3, SOX5, SOX6, SO12, SOX14, SOX15, SOX18 and SRY genes were all significantly downregulated in lung adenocarcinoma patients (HR > 1, log-rank P < 0.05), suggesting that their high expression was associated with poor prognosis. The expressions of SOX5, SOX6, SOX12, SOX17, SOX18 and SRY in lung adenocarcinoma tissues were lower than those in paraneoplastic tissues (P < 0.05). The mRNA expression of the SOX15 gene in lung adenocarcinoma tissues was significantly higher than that in paracancerous tissues (P < 0.05). Moreover, SOX3, SOX5, SOX8, SOX14, SOX17 and SOX18 showed hypermethylation, while SOX15 and SRY showed hypomethylation in lung adenocarcinoma tissues, and the difference was statistically significant (P < 0.05). The low expressions of SOX5, SOX17, and SOX18 were correlated with their promoter region hypermethylation, suggesting that their methylation may also play a role in the occurrence and development of lung adenocarcinoma. Furthermore, hsa-miR-1-3p and miR-499a-5p were positively correlated with SOX5 (r = 0.272,p = 3.87x10− 10) and SOX6 (r = 0.109,p = 1.34x10− 2), respectively. Conclusion The SOX gene family is closely implicated in the onset and progression of lung adenocarcinoma, of which most members can be used as prognostic marker genes for tumor patients.
Lipoma; A Common Neoplasm
Authors: Tabatabaei Seyed Amirhossein Dormiani 
Published: April 2023

Abstract
Objective
In this essay, the manifestations, possible etiologies, diagnostic approachs, treatment methods and complications of lipomas are reviewed.
Methods
A thorough review of the literature is conducted, a series of 12 patients are outlined and briefly examined.
Results
Lipomas may present as asymptomatic tumors or produce distressing signs and symptoms such as pain, swelling and overgrowth. Some lipomas may be identified by physical examination alone. However, magnetic resonance imaging (MRI) is the conclusive method of evaluation especially in deeper lesions.
Conclusions
In the absence of concerning indications or cosmetic concerns, observation stays the standard of care. When pain, itching, compression symptoms or disfigurement impress the patient, surgical removal and pathology assessment are typically recommended. Malignant transformation rarely occurs.
Replication stress causes delayed mitotic entry and Chromosome 12 fragility at the ANKS1B large neuronal gene in human induced pluripotent stem cells
Authors: Kislova Anastasiia V , Zheglo Diana , Pozhitnova Victoria O , Sviridov Philipp S , Gadzhieva Elmira P , Voronina Ekaterina S 
Published: April 2023

Abstract
Substantial background level of replication stress is a feature of embryonic and induced pluripotent stem cells (iPSCs), which can predispose to numerical and structural chromosomal instability, including recurrent aberrations of Chromosome 12. In differentiated cells, replication stress-sensitive genomic regions, including common fragile sites, are widely mapped through mitotic chromosome break induction by mild Aphidicolin treatment, an inhibitor of replicative polymerases. IPSCs exhibit lower apoptotic threshold and higher repair capacity hindering fragile site mapping. Caffeine potentiates genotoxic effects and abrogates G2/M checkpoint delay induced by chemical and physical mutagens. Using 5-ethynyl-2'-deoxyuridine (EdU) for replication labeling, we characterized the mitotic entry dynamics of asynchronous iPSCs exposed to Aphidicolin and/or Caffeine. Under the adjusted timing of replication stress exposure accounting revealed cell cycle delay, higher metaphase chromosome breakage rate was observed in iPSCs compared to primary lymphocytes. Using differential chromosome staining and subsequent locus-specific fluorescent in situ hybridization, we mapped the FRA12L fragile site spanning the large neuronal ANKS1B gene at 12q23.1, which may contribute to recurrent Chromosome 12 missegregation and rearrangements in iPSCs. Publicly available data on the ANKS1B genetic alterations and their possible functional impact are reviewed. Our study provides the first evidence of common fragile site induction in iPSCs and reveals potential somatic instability of a clinically relevant gene during early human development and in vitro cell expansion.
A Sequential “Top-Down” and “Retro Mesenteric Caudo-cranial Superior Mesenteric Artery Approach” for Posteriorly Located Locally Advanced Pancreatic Head Cancers
Authors: Parray Amir M , CHAUDHARI VIKRAM A , Shrikhande Shailesh V , Bhandare Manish S. 
Published: April 2023

Abstract
Purpose: We present a novel surgical strategy with a “Top-Down approach”, followed by “Retro mesenteric caudocranial SMA 1st approach” in posteriorly placed locally advanced pancreatic head cancer with combined SMA/SMV (Superior mesenteric vein) involvement along with invasion of Inferior Vena Cava (IVC) (Case details in Video 1).
Methods & Results: The surgical strategy included Cattell Braasch manoeuvre followed by early pancreatic neck transection. In cases with combined SMA and SMV involvement, often SMV resection and anastomosis is required first before dealing with SMA involvement, depending on the extent and location of vascular involvement. The purpose is dual; to minimize the venous clamp duration and to get a good access for SMA dissection and clearance of the triangle area. Then the SMA is approached from retro mesenteric area and caudocranial SMA divestment was performed, as the SMA wall was uninvolved. Finally, the involved anterior wall of IVC was resected en bloc and the IVC defect was reconstructed by peritoneal patch.
Unlike the conventional methods, retro mesenteric approach allows dissection from the dorsal and peripheral sides of the SMA, allowing direct access to the jejunal branches and inferior pancreaticoduodenal arteries from the caudal aspect of SMA. It also allows adequate dissection of peripancreatic and para-aortic nodes along with peripancreatic nerve plexus resection and peri-arterial divestment of SMA in locally advanced tumours. This approach also provides optimal access to the retroperitoneum allowing for posterior mesopancreatic dissection. (2-4)
Conclusion: The sequential approach addresses the multilevel vascular involvement in sequential manner and allows for a margin negative resection, minimal tumour handling and less blood loss in a difficult scenario. (Videos 1 & 2)
Two-sided estimate of effective thermal conductivity coefficients of a textured composite with anisotropic ellipsoidal inclusions
Authors: Zarubin V.S. , Zimin V.N. , Kuvyrkin G.N. , Savelyeva I.Yu. , Novozhylova O.V. 
Published: April 2023

Abstract
Based on the developed mathematical model of the heat energy transfer in a composite with anisotropic inclusions having a shape of triaxial ellipsoids, the method of calculation of two-sided estimates for components of the effective thermal conductivity tensor of the textured composite is proposed. This technique uses the dual variational formulation of the problem of stationary thermal conductivity in an inhomogeneous body. A case of anisotropic inclusions having the shape of triaxial ellipsoids that main axes of the thermal conductivity tensor coincide with their axes is considered. An example of calculation of two-sided estimates for a conical texture of the composite is given. The results obtained can be used to estimate the possible error in prediction of the effective thermal conductivity coefficients for composites modified with nanostructural elements (including carbon nanotubes).
Mathematics Subject Classification (2010). Primary 80M30; Secondary 74E25
Assessing the Fatigue Life of CFRP Post-Strengthened RC Elements
Authors: MENEGHETTI Leila Cristina , GARCEZ Mônica Regina 
Published: April 2023

Abstract
Upgrading historic structures is one of the most interesting applications of FRP in construction. The possibility to preserve construction technology and original structural conception after an intervention makes the use of FRP an interesting alternative for historic structures. Among these structures, historic bridges are frequently post-strengthened to increase load carrying capacity of structural elements, aiming to bear heavier commercial traffic. In such applications, the fatigue life tends to increase; however, this performance is not fully addressed, which can restrain the effective utilization of FRP in historic structures. Fatigue life becomes a crucial question since the lack of data regarding FRP post-strengthened elements leads to superficial analysis that considers the same S-N curves for different FRP systems and stress ranges, for example, besides other issues. Aiming to improve the fatigue life assessment of RC beams strengthened with FRP, this paper aims to adjust specific S-N curves for different FRP systems and techniques. An extensive database, with experimental data gathered from the literature, has been used to adjust linear regression models to characterize the large scatter between the results of fatigue tests from different sources. Distinct fatigue models have been developed considering three post-strengthening categories: externally bonded reinforcement with FRP strips/sheets and NSMR. Different declivities have been found for the adjusted fatigue life models, highlighting specific aspects of each category. The declivity of the fatigue curves accurately represents the fatigue behavior of FRP-strengthened RC beams and can be used to support proper post-strengthening design to avoid future unnecessary interventions. This paper also presents some real examples of FRP strengthening historic bridges around the globe.
A case report and literature review of McCune–Albright syndrome with SLE
Authors: yan haibo , li yumei , li jingwei 
Published: April 2023

Abstract

Backgroud: Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systems with various clinical manifestations. Renal involvement is common, neurological complications can also occur in lupus, such as cerebral hemorrhage, cerebral infarction, cerebral embolism, etc.But McCune–Albright syndrome with SLE is rare.We report a case to Improve the understanding of diseases and accumulate clinical experience.
Case presentation: A 9.5-year-old girl was admitted to the hospital due to sudden slurred speech and inability to move her left limb for 6 hours. Emergency head CT showed that a round high-density shadow was seen in the right basal ganglia, the largest layer was about 2.2cmx2.4cm. Blood routine: hemoglobin 67g/L, platelets 2×109/L, surgery cannot be performed, and conservative treatment can only be performed. ANA series: particle type 1:320 positive, anti-SSA-52/Ro52+; Urine occult blood 3+, urine protein 3+; anti-β2-glycoprotein I antibody 42RU/ml. Abdominal CT: a small amount of fluid in the abdominal cavity. Lung CT: scattered inflammation in the left lung and right lower lobe. A small amount of pleural effusion bilaterally.One year ago, the child was admitted to our hospital due to intermittent skin bruising for 2 months. The blood routine showed that the platelets were 5×109/L. During the year, the patient's platelets were in single digits,her parents did not give treatment.The patient was diagnosed with "McCune–Albright syndrome" in the Department of Endocrinology and Metabolism in our hospital 8 years ago, and was treated with oral "tamoxifen", but the drug has been discontinued for 2 years. MRV: The left transverse sinus is not shown, and the left internal jugular vein and sigmoid sinus are slender. After admission, patients were treated with Respiratory support,hormone shock, immunosuppressant, dehydration and intracranial pressure reduction, platelet transfusion, rehabilitation, etc.After the rehabilitation treatment, the child was conscious and could communicate easily, but the lower limbs could not be straightened.
Conclusion: SLE can involve multiple systems and various complications. McCune–Albright syndrome with SLE is rare. Early diagnosis and treatment are key to improving the prognosis of children.
Vibro-impact damper dynamics depending on system parameters
Authors: Lizunov Petro P. , Pogorelova Olga , Postnikova Tetiana 
Published: April 2023

Abstract
Purpose
The considered vibro-impact damper corresponds to the scheme of single-sided vibro-impact nonlinear energy sink (SSVI NES). Although the vibration engineering has been studying the problem of mitigation the undesirable vibrations for many years, it remains relevant today. The dynamic behavior and efficiency of many different NES types are strongly dependent on system parameters and initial conditions. The present research aims to show the rich complex dynamics of vibro-impact damper with optimized parameters and its effectiveness when changing parameters both its own and periodic exciting force.
Methods
We assume that an impact has a finite duration and simulate it using nonlinear Hertz contact force. The direct numerical integration of stiff differential motion equations is carried out using the software Octave. The optimization of the damper parameters is performed by the Octave and MatLab solvers. We analyze the displacements and velocities time histories, the phase trajectories, the topological structure of numerical Poincaré maps, the contact forces graphs for the oscillatory regimes diagnostics.
Results
Two dampers versions with optimized parameters mitigate the primary structure vibrations; the absorber with a larger mass reduces them more strongly. The system motion with a lighter damper is almost periodic with rare bursts of irregular movement, but the system motion with a heavier damper is essentially irregular with complex dynamics. The vibrations mitigation occurs in a wide range of the exciting force amplitudes, but in the range of its frequencies only above the resonant one; the damper presence shifts the resonant peak.
Conclusions
The efficiency of SSVI NES with optimized parameters is demonstrated when changing the exciting force parameters. The parameters ranges where the vibrations mitigation occurs are shown. The results of damper parameters optimization may be ambiguous and should be checked and analyzed. They can determine such parameters values that provide good vibrations reduction, but create irregular motion regimes with complex dynamics; this should be taken into account when designing a SSVI NES.
Synthesis and Characterization of Mesoporous SBA-15 Using Different Dispersing Agents
Authors: saber Yousra , Hussien Hussien 
Published: April 2023

Abstract

Spherical mesoporous SBA-15 with a high surface area was successfully synthesized using hydrothermal method. Pluronic p123 triblock co-polymer was utilized as a directing agent, sodium silicate prepared from Iraqi silica sand was considered a silica precursor, and (1–3) g of different dispersing agents of PVA, PVP, and SDS were applied. The prepared SBA-15 characterized using x-ray diffraction (XRD), Fourier transform infrared (FTIR), atomic force microscope (AFM), nitrogen adsorption desorption using Brunauer Emmett Teller (BET), and field emission scanning electron microscopy (FESEM). The X-ray diffraction pattern indicated to pure SBA-15 single peak at (2Ɵ= 20–250), and FTIR spectroscopy represented the main functional groups of (Si = O), (Si-O-Si), and (Si-OH). The dispersing agents influenced the surface area ranging from 349 to 871 cm2/g, pore volume from 0.17 to 0.43 cm3/g, and the pore size from 2 to 2.5 nm. The highest surface area, and pore volume were obtained using 2g of PVP dispersing agent. The deformation of the spherical morphology of SBA-15 particles occurred beyond the addition of 1g of dispersing agents.
Water treatment membranes embedded with a stable and bactericidal nanodiamond material
Authors: Colon Abelardo , Avalos Javier , Weiner Brad R. , Morell Gerardo , Ríos Rafael 
Published: April 2023

Abstract

Filtration has emerged as a critical technology to reduce waterborne diseases caused by poor water quality. Filtration technology presents key challenges, such as membrane selectivity, permeability and biofouling. Nanomaterials can offer solutions to these challenges by varying the membranes' mechanical and bactericidal properties. This research uses nanodiamond particles with facile surface functionality and biocompatibility properties that are added to membranes used for filtration treatments. Scanning and transmission electron microscopy (SEM and TEM) and Fourier transform infrared spectroscopy (FTIR) were performed to study the membrane surface. FTIR spectra confirms an increase in oxygen functional groups onto the ultradispersed diamond's (UDD) surface following acid treatment. SEM images show particle deagglomeration of functionalized UDD at the membrane surface. Tensile strength tests were done to measure the UDD mechanical properties and Coliscan membrane filtration characterization was performed to determine the filter effectiveness. Polyether sulfone (PES) and polyvinylidene (PVDF) membranes expressed a change in their yield point when UDD was incorporated into the porous matrix. A significant microorganism reduction was obtained and confirmed using t-test analysis at a 95% level of confidence. UDD-embedded membranes exhibit a significant bactericidal reduction compared to commercial membranes suggesting these membranes have the potential to enhance current membrane filtration systems.