bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and adverse perinatal outcomes of anaemia in the third trimester of pregnancy in Hebei Province, China
Authors: Tian Mei-Ling , Ma Guo-Juan , Du Li-Yan , Xiao Yuan-Ge , Zhang Ying-kui , Tang Zeng-Jun 
Published: April 2023

Abstract

Background
Anaemia in pregnancy is one of the most frequent complications related to pregnancy and is a public health concern. This article examines the prevalence of anaemia in the third trimester of pregnancy and the associations between anaemia and adverse perinatal outcomes in Hebei Province, China.

Methods
We used SPSS software to describe the incidence of anaemia in the third trimester of pregnancy in Hebei Province and analysed the clinical characteristics in anaemic patients and the relationship between anaemia and adverse pregnancy outcomes.

Results
The overall prevalence of anaemia in the third trimester of pregnancy was 35.0% in Hebei Province. The prevalence of anaemia in the population with a high education level was lower than that in the population with a low education level. The incidence rate in rural areas was higher than that in urban areas. After adjustment for confounding factors, anaemia in the third trimester of pregnancy is an independent risk factor in terms of placenta previa, placental abruption, uterine atony, pre-eclampsia, gestational diabetes mellitus, heart disease, postpartum haemorrhage, premature birth, laceration of birth canal, puerperal infection, caesarean section and large for gestational age.

Conclusions
The prevalence of anaemia in the third trimester of pregnancy is associated with an increased risk of adverse perinatal outcomes. A comprehensive approach to prevent anaemia is needed to improve maternal and child health outcomes.
Penalized weighted least-squares estimate for variable selection on correlated multiply imputed data
Authors: Li Yang , Yang Haoyu , Yu Haochen , Huang Hanwen , Shen Ye 
Published: April 2023

Abstract
Considering the inevitable correlation among different datasets within the same subject, we propose a framework of variable selection on multiply imputed data with penalized weighted least squares (PWLS–MI). The methodological development is motivated by an epidemiological study of A/H7N9 patients from Zhejiang province in China, where nearly half of the variables are not fully observed. Multiple imputation is commonly adopted as a missing data processing method. However, it generates correlations among imputed values within the same subject across datasets. Recent work on variable selection for multiply imputed data does not fully address such similarities. We propose PWLS–MI to incorporate the correlation when performing the variable selection. PWLS–MI can be considered as a framework for variable selection on multiply imputed data since it allows various penalties. We use adaptive LASSO as an illustrating example. Extensive simulation studies are conducted to compare PWLS–MI with recently developed methods and the results suggest that the proposed approach outperforms in terms of both selection accuracy and deletion accuracy. PWLS–MI is shown to select variables with clinical relevance when applied to the A/H7N9 database.
SARS2Mutant: SARS-CoV-2 amino-acid mutation atlas database
Authors: Rahimian Karim , Arefian Ehsan , Mahdavi Bahar , Mahmanzar Mohammadamin , Kuehu Donna Lee , Deng Youping 
Published: April 2023

Abstract
The coronavirus disease 19 (COVID-19) is a highly pathogenic viral infection of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulted in the global pandemic of 2020. A lack of therapeutic and preventive strategies has quickly posed significant threats to world health. A comprehensive understanding of SARS-CoV-2 evolution and natural selection, how it impacts host interaction, and phenotype symptoms is vital to develop effective strategies against the virus. The SARS2Mutant database (http://sars2mutant.com/) was developed to provide valuable insights based on millions of high-quality, high-coverage SARS-CoV-2 complete protein sequences. Users of this database have the ability to search for information on three amino acid substitution mutation strategies based on gene name, geographical zone, or comparative analysis. Each strategy is presented in five distinct formats which includes: (i) mutated sample frequencies, (ii) heat maps of mutated amino acid positions, (iii) mutation survivals, (iv) natural selections and (v) details of substituted amino acids, including their names, positions, and frequencies. GISAID is a primary database of genomics sequencies of influenza viruses updated daily. SARS2Mutant is a secondary database developed to discover mutation and conserved regions from the primary data to assist with design for targeted vaccine, primer, and drug discoveries.
Inferior and precordial ST-segment elevation myocardial infarction due to large wrap-around left anterior descending artery occlusion
Authors: Tamura Hiroto , Tobetto Yohei , Seno Akiho , Kishi Koichi 
Published: April 2023

Abstract
Left anterior descending artery (LAD) occlusion normally develops into precordial ST-segment elevation; however, we describe a case of a 50-year-old man with inferior and precordial ST-segment elevation myocardial infarction that resulted from proximal occlusion of the wrap-around LAD perfusing the anterior and inferior wall. We performed early and prompt reperfusion and were able to save the patient without any complications. A wrap-around LAD perfuses a large myocardial area; therefore, this type of coronary occlusion causes severe myocardial damage and has a poor prognosis. The rates of new-onset heart failure and heart failure rehospitalization are also high. Simultaneous inferior and precordial ST-segment elevations on electrocardiography suggest acute myocardial infarction with a wrap-around LAD lesion, which requires prompt revascularization. More careful medications for heart failure and follow-up should be also required even after discharge in such case.
The price penalty on meat substitutes—Consumers prefer reduced meat portions over novel meat alternatives and authentic vegetarian dishes—Final stage of a registered report
Authors: Lemken Dominic , Langen Nina 
Published: April 2023

AbstractDue to growing health and environmental problems related to the overconsumption of meat in western diets, we investigated consumer demand for dishes that reduce or replace beef with: (1) plant-based products that mimic the functionality and taste, (2) authentic plant-based ingredients that just mimic the functionality, and (3) halved beef portion sizes. We implemented a peer-reviewed and pre-registered (https://doi.org/10.1371/journal.pone.0252675) conjoint experiment to elicit the WTP across three popular beef dishes and three reduction options each. The conjoint experiment includes the dish configuration, waiting time, CO2 information, and an individually adapted price vector, where the prices depend on previous choices. Consumers favoured the reduced portion sizes when faced with the meat reduction task. This reduction preference is even more prevalent among regular consumers of the meat dish, i.e. consumers with relevant consumption habits to reconsider. We discuss strategies to reformulate meat dishes that are particularly promising with the current bulk market and address regular meat eaters. Lastly, we indicate the type of consumers with high or low preferences for each dish.
P156 Evidence of Type I interferon activation during vascular manifestations of systemic sclerosis
Authors: Di Donato Stefano , Hughes Michael , Geloshi Klaudian , De Lorenzis Enrico , Kakkar Vishal , Ross Rebecca , O'Connor Philip , Kubassova Olga , Del Galdo Francesco 
Published: April 2023

Abstract

Background/Aims
Vascular involvement in systemic sclerosis (SSc) is known to start even before clinical diagnosis, driving digital ulcer (DU) disease. Later in the disease natural history, it can cause pulmonary artery hypertension (PAH) among other manifestations. Despite the proven immune origin of scleroderma, vascular involvement is not currently targeted by immune driven interventions. Similarly, few data are available on immune or inflammatory biomarkers and outcome measures of vascular disease in SSc. Digital artery volume index (DAVIX) has been recently proposed as an imaging surrogate outcome measure of vascular disease activity in SSc.

Methods
86 patients attending our scleroderma program were consecutively enrolled for the evaluation of serum IFN score as previously described [2]. Clinical features, including presence or history of DUs, presence of PAH and DLCO, were recorded. DAVIX of the dominant hand’s fingers was calculated using time of flight magnetic resonance imaging analysed through IAG proprietary algorithm, as previously described [1]. Medians were compared by Mann-Whitney-Wilcoxon test; correlation with clinical parameters was performed using Spearman’s or Pearson test, as appropriate (R).

Results
62 patients fulfilled the 2013 ACR/EULAR classification criteria for SSc (diffuse cutaneous 24.6%, limited cutaneous 75.4%), whereas 23 were classified as very early diagnosis of scleroderma (criteria score between 6 and 8). 23 patients had DU disease (history of DUs in the previous 24 weeks, presence of DUs at baseline assessment, or onset of new DUs during the following 24 weeks). 18 patients had reduced DLCO (&lt;70) with FVC/DLCO&gt;1.8 (suspected PAH). DAVIX showed a negative correlation with disease duration (r=-0.33 and p = 0.003) and with FVC/DLCO ratio (r=-0.34 and p = 0.009). Patients with DU disease presented lower DAVIX than patients without (p = 0.018). DAVIX showed a significant correlation with serum IFN score (r=-0.24, p &lt; 0.032). Accordingly, patients classified as IFN-HI had lower DAVIX than those within the IFN-LO group (p = 0.016).

Conclusion
DAVIX correlated both with presence of DU disease, DLCO and disease duration. The correlation of DAVIX and serum IFN score does support the notion of innate immune involvement in vascular disease manifestations of SSc. Prospective testing in the context of randomised controlled trials will determine the value of DAVIX as a surrogate outcome measure of vascular disease severity in SSc.
S. Di Donato: None. M. Hughes: None. K. Geloshi: None. E. De Lorenzis: None. V. Kakkar: None. R. Ross: None. P. O'Connor: None. O. Kubassova: Consultancies; Image Analysis Group CEO. F. Del Galdo: Grants/research support; Abbvie, AstraZeneca, Boeringher-Ingelheim, Capella, Chemomab, Janssen, Kymab, Mitsubishi-Tanabe.
E042 The Newcastle Giant Cell Arteritis (GCA) Fast Track Clinic: a clinical service evaluation
Authors: Lin Chung M , Berry Joe , Thompson Ben , Heaney Jonathan , Houghton Karolyn , Baker Kenneth , Reynolds Gary , Lorenzi Alice 
Published: April 2023

Abstract

Background/Aims
Patients with suspected new-onset giant cell arteritis (GCA) require urgent specialist assessment to establish a diagnosis. Early review reduces unnecessary treatment with high dose glucocorticoids in those without GCA and enhances sensitivity of temporal artery ultrasound. Ensuring patients are rapidly triaged and diagnosed poses a logistical challenge for rheumatology departments working alongside colleagues in both primary care and ophthalmology. To address this, we established a rheumatology-led Newcastle Hospital GCA fast track clinic, a service led by four consultant rheumatologists who perform clinical assessments and temporal artery ultrasound scans.

Methods
Data were collected prospectively from 2017. We performed a clinical service evaluation based on a retrospective review of clinical records of patients assessed in this service between 2017 to 2020.

Results
A total of 626 consecutive patients were assessed, with 145 (23%) diagnosed with GCA over the four-year period. Average age was 72 (range 41-96 years) and 452 (72%) were female. The cardinal symptoms of headache, jaw claudication and visual disturbance were present in 518, 103 and 283 patients respectively. The majority of referrals came from ophthalmology (42%) and primary care (34%). 614 patients had an ultrasound scan performed, returning a positive result in 121 (19.7%), negative in 415 (67.6%) and inconclusive in 78 (12.7%). A biopsy was requested for 147 patients over the four-year period; 33 were positive, 95 negative and six were inconclusive. Within this cohort, 47 patients had a biopsy performed despite a negative ultrasound scan, of which five were found to be positive for GCA.

Conclusion
Our data illustrate the key clinical, imaging and histological findings within one of the largest inception cohorts of GCA in the UK and demonstrate the feasibility of a one-stop rapid access clinical service for patient benefit.
Disclosure
C.M. Lin: None. J. Berry: None. B. Thompson: None. J. Heaney: None. K. Houghton: None. K. Baker: None. G. Reynolds: None. A. Lorenzi: None.
SIZE-SPECIFIC DOSE ESTIMATES IN PEDIATRIC BRAIN CT IN RELATION TO AGE AND WEIGHT
Authors: Fujii Kaoru , Inoue Yusuke , Itoh Hiroyasu , Sasa Ryosuke , Hata Hirofumi , Mitsui Kohei 
Published: April 2023

Abstract
The size-specific dose estimate (SSDE) is used for radiation dose management in computed tomography (CT) and represents patient’s absorbed dose more accurately than volume CT dose index. The relationship between SSDE and age or weight was investigated using 980 pediatric brain CT scans. Monolinear, power, and bilinear functions were fitted to the plots of SSDE against age or weight, and SSDE was estimated using the obtained functions. SSDE showed a biphasic increase with increasing age and weight: a rapid initial increase and subsequent a slow increase. Bilinear and power functions were successfully fitted to the plots, and mean estimation errors were close to 0, irrespective of the age or weight group. The standard SSDE values estimated from the obtained functions agreed well with the median values for each age or weight group. The curve-fitting method is expected to aid radiation dose management for pediatric brain CT using SSDE.
Barriers as moderators in the innovation process
Authors: de Moraes Silva Diego R , Vonortas Nicholas S , Furtado André T 
Published: April 2023

Abstract
This article investigates the effect of financial and non-financial barriers on innovativeness. Using microdata from Brazil, it provides a rare detailed empirical investigation of this type in developing countries. The analysis is based on a novel conceptual framework of the moderating role of barriers to innovation. Research and development expenditure and informal methods of intellectual property protection are the innovation determinants least affected by obstacles to innovation. This is in sharp contrast to company size, whose effect appeared quite sensitive to barriers of all kinds. Disembodied and embodied knowledge outsourcing interact differently with different constraints: while the former appeared helpful in working around different types of barriers in low-tech sectors, the latter was more useful in addressing financial constraints in high-tech sectors. Finally, cooperation with other firms was negatively affected by obstacles when firms seek more radical innovations, whereas cooperation with research and education organizations proved attractive for companies facing organizational constraints.
LncRNA NORAD regulates the mechanism of the miR-532-3p/Nectin-4 axis in pancreatic cancer cell proliferation and angiogenesis
Authors: Wang Kaiqiong , Chen Zhiju , Qiao Xin , Zheng Jinfang 
Published: April 2023

Abstract

Backgound
Pancreatic cancer (PC) is one of the deadliest cancers worldwide, and cell proliferation and angiogenesis play an important role in its occurrence and development. High levels of lncRNANORAD have been detected in many tumors, including PC, yet the effect and mechanism of lncRNA NORAD on PC cell angiogenesis are unexplored.

Methods
qRT.PCR was applied to quantify lncRNA NORAD and miR-532-3p expression in PC cells, and a dual luciferase reporter gene was used to verify the targeting effects of NORAD, miR-532-3p and Nectin-4. Then, we regulated NORAD and miR-532-3p expression in PC cells and detected their effects on PC cell proliferation and angiogenesis using cloning experiments and HUVEC tube formation experiments.

Results
LncRNA NORAD was upregulated and miR-532-3p was downregulated in PC cells compared with normal cells. Knockdown of NORAD inhibited PC cell proliferation and angiogenesis. LncRNA NORAD and miR-532-3p competitively bound to promote the expression of the miR-532-3p target gene Nectin-4, thereby promoting proliferation and angiogenesis of PC cells in vitro.

Conclusion
LncRNA NORAD promotes the proliferation and angiogenesis of PC cells by regulating the miR-532-3p/Nectin-4 axis, which may be a potential biological target in the diagnosis and treatment of clinical PC.
Feasibility Trial of Intensity Modulated Proton Therapy to Reduce Toxicity in Anal Cancer Patients
Authors: Nelson Bailey , Meier Teresa , Zhang Yin , Wang Kyle , Mascia Anthony E. , Paquette Ian , Thompson Earl , Rafferty Janice , Snyder Jonathan , Olowokure Olugbenga , Sohal Davendra , Kharofa Jordan 
Published: April 2023

Purpose:
The purpose of this trial was to assess the patient and physician-reported toxicity in anal cancer patients undergoing definitive chemoradiation with intensity-modulated proton therapy (IMPT).

Methods:
Patients with stage II and III anal cancer were treated with IMPT. All patients received 2 cycles of 5-fluorouracil and mitomycin concurrently with radiation. Toxicity was assessed at baseline, weekly during chemoradiation, and in follow-up using physician-graded common terminology criteria for adverse events (CTCAE) v 4.0 and PRO-CTCAE. The primary endpoint was to define point estimates and 95% CI for acute ≥ grade 2/3 gastrointestinal (GI), genitourinary (GU), dermatologic, and hematologic toxicity. The proportion of PRO-CTCAE questions scored ≥3 for each domain was compared with the baselinse. The proportion of ≥ grade 2 and ≥ grade 3 toxicities were compared with historic intensity-modulated radiotherapy patients treated on RTOG 0529.

Results:
Fourteen patients were enrolled from 2017 to 2020. Rates of physician-reported GI, GU, dermatologic, and hematologic toxicity were not significantly different between patients treated with IMPT compared with patients treated with intensity-modulated radiotherapy. Rates of patient-reported dermatologic and GU toxicity were low at baseline with a peak at week 6 (91% and 58% PRO-CTCAE items ≥ grade 3, respectively) and normalization to baseline 3 months after IMPT. In contrast, the proportion of high-grade PRO-CTCAE GI scores was 40% at baseline, which persisted through 1-year posttreatment.

Conclusions:
Clinician-reported toxicity was not improved with IMPT in the context of this underpowered trial. High-grade GI symptoms persisted for 12 months and were similar to baseline. Additional measures are needed to minimize acute and chronic toxicity related to chemoradiation.
Clinical outcomes and complications following intraocular lens exchange in the setting of an open or intact posterior capsule
Authors: Alsetri Hasan , Masket Samuel , Fram Nicole , Sandoval Hector , Cabang Julieanne , McLachlan Jessie 
Published: April 2023

Purpose:
To assess whether there are added risks when performing intraocular lens (IOL) exchange in the setting of an open posterior capsule (OPC) when compared with a closed posterior capsule (CPC) IOL exchange.

Setting:
Private practice, Los Angeles, California.

Design:
Nonrandomized and unmasked retrospective chart review.

Methods:
Eyes undergoing IOL exchange solely to relieve optical symptoms, with open or intact posterior capsules, were included. Eyes undergoing IOL exchange due to IOL malposition or dislocation were excluded. Eyes with preexisting, uncontrolled glaucoma and inflammation and eyes with a visual potential worse than 20/40 (Snellen) were also excluded. The main outcome measures were the postoperative complications compared between the OPC and CPC groups.

Results:
90 eyes of 75 patients undergoing IOL exchange were included in this study; 38/90 eyes had an OPC, and 52/90 eyes had a CPC. 3/38 in the OPC group and 2/52 in the CPC group experienced worsening intraocular pressure control. 1/38 in the OPC group experienced chronic inflammation. 2/38 in the OPC group and 2/52 in the CPC group experienced cystoid macular edema. 1/52 in the CPC group experienced a retinal tear. Statistically or clinically significant differences in postoperative complications between the OPC and CPC groups were not found.

Conclusions:
In the hands of an experienced surgeon, IOL exchange with an OPC appear red to be just as safe as IOL exchange with a CPC; when deemed necessary, experienced surgeons may perform an IOL exchange safely in the presence of an OPC.
Approach to a spontaneously ruptured posterior polar cataract
Authors: Chee Soon-Phaik , Ayres Brandon D. , Lee Mun Wai , Vasavada Vaishali , Fram Nicole R. , Srinivasan Sathish 
Published: April 2023

A 61-year-old man presented with gradual blurring of vision and glare in both eyes for a couple of years, with worsening of the vision in his right eye over the past 2 months. He had no medical history of note.
On clinical examination, his visual acuities were 20/80 in the right eye and 20/30 in the left eye, uncorrected. The cornea was clear, and the anterior chamber (AC) was deep in both eyes. He had bilateral mild nuclear sclerosis with round central onion-ring–like posterior opacities. The opacities measured approximately 2 mm in diameter and were marginally larger in the right eye than in the left eye (Figure 1

JOURNAL/jcrs/04.03/02158034-202305000-00018/figure1/v/2023-08-19T002654Z/r/image-tiff

). In addition, there were 2 curvilinear lines across the right posterior capsule (PC), one of which passed across the lens opacity (Figure 2

JOURNAL/jcrs/04.03/02158034-202305000-00018/figure2/v/2023-08-19T002654Z/r/image-tiff

). Fundus examination was normal in both eyes, and the vitreous was clear. Optical coherence tomography (OCT) of the macular and optic nerve in both eyes was normal. The endothelial cell count in both eyes exceeded 2000 cells/mm2.
He had been told by a previous ophthalmologist to have bilateral cataracts and was now keen for surgery starting with the right eye. He works as a manager in a large company and is an avid golf player. He is emmetropic and wears spectacles for near work. Optical biometry using predicated posterior corneal astigmatism did not recommend a toric intraocular lens (IOL). He had done his internet research on IOL options and requested trifocal IOLs.
What is your surgical plan for right cataract removal? Explain which IOL you would choose to implant.