bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel nomogram predicting overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in portal hypertension patients
Authors: Liao Yong , Zhang Lin , Yue Zhen-dong , Fan Zhen-hua , Wu Yi-fan , Zhang Yu , Dong Cheng-bin , Wang Xiu-qi , Cui Ting , Meng Ming-ming , Bao Li , Liu Fu-quan , Wang Lei 
Published: February 2023

Abstract
Rationale and Objectives: We aim to develop a nomogram to predict overt hepatic encephalopathy (OHE) after transjugular intrahepatic portosystemic shunt (TIPS) in patients with portal hypertension, according to demographic/clinical indicators such as age, creatinine, blood ammonia, indocyanine green retention rate at 15 minutes (ICG-R15) and percentage of Portal pressure gradient (PPG) decline.
Materials and Methods: In this retrospective study, 296 patients with portal hypertension who received elective TIPS in Beijing Shijitan Hospital from June 2018 to June 2020 were included. These patients were randomly divided into a training cohort (n=207) and a validation cohort (n=89). According to the occurrence of OHE, patients were assigned to OHE group and non-OHE group. Both univariate and multivariate analyses were performed to determine independent variables for predicting OHE after TIPS. Accordingly, receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA) were used to compare the accuracy and superiority of a novel model with conventional Child-Pugh and MELD scoring model.
Results: Age (OR=1.036, 95% CI:1.002-1.070, p=0.037), Creatinine (OR=1.011, 95% CI:1.003-1.019, p=0.009), Blood ammonia (OR=1.025, 95% CI:1.006-1.044, p=0.011), ICG-R15 (OR=1.030, 95% CI:1.009-1.052, p=0.004) and Percentage decline in PPG (OR=1.068, 95% CI:1.029-1.109, p=0.001) were independent risk factors for OHE after TIPS using multifactorial analysis. A nomogram was constructed using a well-fit calibration curve for each of these five covariates. When compared to Child-Pugh and MELD score, this new nomogram has a better predictive value (C-index=0.828, 95% CI:0.761-0.896). Consistently, this finding was reproduceable in validation cohort and confirmed with DCA.
Conclusion: A unique nomogram was developed to predict OHE after TIPS in patients with PHT, with a high prediction sensitivity and specificity performance than commonly applied scoring systems.
Outcomes of Standalone Ab Interno Trabeculotomy in the Treatment of Open-Angle Glaucoma in Eyes with High Myopia
Authors: Yoshida Takeshi , Nomura Takuhei , Yoshimoto Sota , Ohno Motohisa , Ito Taiju , Horie Shintaro , Ohno-Matsui Kyoko 
Published: February 2023

Abstract
Background
We retrospectively evaluate the long-term efficacy and safety of trabeculotomy glaucoma surgery in treating open-angle glaucoma (OAG) in eyes with high myopia (HM).
Methods
This study included 20 eyes with HM (axial length ≥ 26.5 mm) and OAG; age, preoperative IOP (intraocular pressure), and sex-matched 20 non-HM eyes (axial length < 26.5 mm) served as controls. Each eye underwent standalone ab interno trabeculotomy using a Kahook dual blade. A follow-up examination was performed 36 months after surgery. The main outcome measure was the operative success rate (i.e., a ≥ 20% pre- to post-operative reduction in IOP with or without IOP-lowering medication). Kaplan-Meier analysis was employed as a measure of surgical success. The secondary outcome measures were postoperative IOP, the number of glaucoma medications, and postoperative complications.
Results
IOP and the number of glaucoma medications were statistically significantly reduced at all postoperative follow-up examinations. The Kaplan-Meier analysis demonstrated that the probability of postoperative success at 36 months was 45% and 65% for HM and non-HM eyes, respectively. In the HM group, the presence of pathological myopia (PM) was statistically significant risk factor for surgical failure. No critical postoperative complications were detected.
Conclusions
In our study, the long-term efficacy of ab interno trabeculotomy in HM eyes with OAG was inferior to that in non-HM eyes with OAG. Our findings suggest that surgical indications for trabeculotomy in HM should be determined based on the presence of PM.
Vertical root fracture resistance and crack formation of root filled teeth treated with or without minimally invasive endodontics
Authors: Rathke Andreas , Frehse Henry , Muche Rainer 
Published: February 2023

Abstract
The aim was to investigate the vertical root fracture (VRF) resistance and crack formation of root filled teeth treated with (+) or without (–) minimally invasive endodontic (MIE) preparation. Human maxillary central incisors of similar size were decoronated, randomized into six groups (n = 18, power = 0.9) and embedded in acrylic blocks with artificial periodontal ligament. In the +MIE group, root canals were prepared with nickel-titanium (NiTi) rotary files up to size #40, taper 0.04 and filled with conventional gutta-percha/sealer (C) or adhesive (A) single-cone obturation. Preparations of the –MIE group were enlarged with NiTi rotary and K-files up to ISO size #80 and filled according to C or A. Controls either received no treatment or left unfilled after preparation. After thermocycling and staircase loading in a chewing simulator, the crack formation on the root surface was microscopically examined and classified as no defect, craze line, vertical crack, and horizontal crack. Subsequently, the samples were loaded until root fracture. Data were analyzed by Kruskal-Wallis test and Mann-Whitney U test with Bonferroni correction. Post hoc analysis revealed no significant difference in the incidence of defects between the groups (P ≥0.0772). VRF resistance was significantly higher in untreated teeth than in +MIE/C (P = 0.0202), but not significantly different between other groups (P ≥ 0.0680). Both VRF resistance and crack formation of root filled teeth were statistically indistinguishable with or without MIE preparation. Adhesive root filling did not improve the fracture susceptibility. Most dentin defects were vertical root cracks.
The Efficacy of an Anatomy and Ultrasonography Workshop on Improving Residents' Confidence and Knowledge in Regional Anesthesia
Authors: Harmon Derek J. , Boscardin Christy K. , Cohen Neal H. , Braehler Matthias R. 
Published: February 2023

Abstract
Background
Ultrasound Guided Regional Anesthesia (UGRA) has become the standard for regional anesthesia practice, but there is not a standardized educational approach for training residents. The objective of this study was to evaluate the efficacy of an UGRA workshop utilizing the theoretical framework of embodied cognition for anesthesiology residents.
Methods
A workshop was developed consisting of didactics, scanning training on standardized patients (SPs) and anatomy reviews on prosected cadavers that focused on the most common UGRA procedures for the upper and lower extremity. At the beginning of the workshop and at the end of the workshop residents completed pre-test and pre-confidence surveys, as well as post-test and post-confidence surveys, respectively to assess the impact of the workshop.
Results
39 residents (100% of the possible residents) participated in the workshop in 2019. Residents’ confidence in identifying relevant anatomy for the most common UGRA procedures significantly increased in 13 of the 14 measurements. Residents’ knowledge gain was also statistically significant from the pre-test to post-test (20.13 ± 3.61 and 26.13 ± 2.34; p < .0001). The residents found the course overall to be very useful (4.90 ± .38) and in particular the cadaveric component was highly rated (4.74 ± .55).
Conclusions
In this study, we developed a workshop guided by the embodied cognition framework to aid in shortening the overall learning curve of UGRA for anesthesiology residents. Based on our results this workshop should be replicated by institutions that are hoping to decrease the learning curve associated with UGRA and increase residents’ confidence in identifying the relevant anatomy in UGRA nerve blocks.
Relationship among symptoms, quality of life, and complementary and alternative medicines use among patients undergoing hemodialysis in French-speaking Switzerland
Authors: Kemnitz Marie , Antonini Matteo , Delmas Philippe 
Published: February 2023

Abstract
Background
Chronic renal disease is considered a main public health problem due to its high prevalence in the population. The solution of choice currently available is kidney transplantation but when this option is not available, blood purification treatments, notably haemodialysis (HD), are necessary. The presence of chronic renal disease combined with this demanding medical procedure leads to a hard symptomatology. To face this situation, HD patients often resort to complementary and alternative medicines (CAM) as they perceive that the healthcare professionals aren’t paying enough attention to their quality of life.
Given this background, we aim to describe the prevalence and the type of the CAM used among HD patients and their possible relations with patients’ symptomatology and quality of life.
Methods
We interviewed 122 patients, undergoing hemodialysis in three hemodialysis centers in French-speaking Switzerland, about the presence of symptoms, their quality of life, and the possible use of CAM. Cluster analysis was used to create patients’ profiles about CAM use and regression analysis to explore the links between symptoms’ presence, patients’ quality of life, and CAM use.
Results
Our results show a large use of CAM: almost two HD patients out of three uses at least one CAM. Using cluster analysis, we were able to identify five patients’ profiles: non-users (37.5% of our sample), users of herbal medicine (20.5%), users of prayer-based practices (18.2%), people mainly using massages (9.1%), and a residual group including the users of other CAM, with a predominance of meditation (14.8%). As expected, we observe a negative relation between the number of declared symptoms and patients' quality of life. Contrarily, we observe no relation between the use of CAM and the presence of symptoms. Our results show a positive relationship between the use of CAM and patients’ overall perception of health as well as the psychological dimension of their quality of life. No relationship is observed with other dimensions of quality of life, notably the physical dimension.
Conclusions
Our results suggests that CAMs aren’t used as a substitute of official medicine but as a parallel support to HD patients’ quality of life.
Decolorization of multicomponent dye-laden wastewater by modified waste fly ash: A parametric analysis for an anionic and cationic combination of dyes
Authors: Akhtar Namrah , Aslam Zaheer , Shawabkeh Reyad A. , Baig Nadeem , Aslam Umair , Ihsanullah Ihsanullah , Khan Salahuddin 
Published: February 2023

Abstract
WFA modification was done by its reaction with the mixture of ammonia solution and phosphoric acid. BET analysis of modified WFA elucidate pore volume and surface area of 0.017cm3/g, 11.1m2/g respectively. Thermo-Gravimetric Analysis (TGA) confirmed the 45% loss in weight for the WFA whereas, for modified WFA, the loss was about 12%. XRD results proposed the improved crystallinity of the modified WFA. Moreover, the zeta-potential of -40mV indicates the favorable removal efficiency, against the pH value of 6.41. Regression results from the comparison of order-based kinetic models suggest that nth model parameters justify the complex nature of the adsorption mechanism with its feasible correlation coefficient (R2 > 0.95) and its lower error values for both single and binary solutions. Monolayer coverage capacities for a single solution system of Methylene Blue (MB), Rhodamine-6G (Rh) and Methyl Orange (MO) were 24.93mg/g, 24.83mg/g and 14.95mg/g respectively. Further, the isothermal model’s results suggest that the “Extended Sips” model gives relatively higher R2= 0.99 values and deals with the failed assumptions of both the Langmuir and Freundlich models. The thermodynamic model generated results conclude that involved single and binary physisorption processes were spontaneous and endothermic in the case of cation dyes solution and for MB/MO mixture it was exothermic.
Evolutionary game analysis for non-cooperative behavior of entities in a closed-loop green supply chain under government intervention
Authors: Bera Subhamoy , Giri Bibhas C. 
Published: February 2023

Abstract
Decentralized behavior of entities in a green supply chain plays a significant role in pricing and green innovation effort to produce more environment-friendly products at affordable prices. Government intervention (e.g, subsidy for green production, Cap-and-Trade Policy (CTP)) is a crucial component for diminishing carbon emissions due to the manufacturing of new products and recycling of used products. In this study, we investigate the long-term decentralized behavior of supply chain members and the evolutionary stable decision of the government to intervene in price and sales effort competition among retailers. More precisely, through an evolutionary game theoretic framework, we look for the non-cooperative behavior of the population of retailers who compete with each other over price and sales effort under government intervention and CTP. The model is further extended to analyze the evolutionary behavior of the population of government whether it intervenes or not in the same situation. Our study demonstrates that the whole population of retailers adopts the retailer-led Stackelberg strategy to deal with the manufacturer, and the most significant finding is that, in such a situation, government intervention is always favorable regardless of what the supply chain decides. Numerical results exhibit that whenever retailers dominate the market, it becomes beneficial for both retailers as well as the entire supply chain, and the environmental performance of the product also increases compared to the Vertical Nash scenario.
Effect of miR-149-5p on intramuscular fat deposition in pigs based on metabolomics and transcriptomics
Authors: Liu Yingke , Wei Yilin , Dou Yaqing , Li Chenlei , Song Chenglei , Zhang Zhe , Qi Kunlong , Li Xinjian , Qiao Ruimin , Wang Kejun , Li Xiuling , Yang Feng , Han Xuelei 
Published: February 2023

Abstract
As one of the important traits in pig production, meat quality has important research significance and value. Intramuscular fat (IMF) content is one of the most important factors affecting pork quality. Many experimental studies have shown that IMF content is closely related to the flavor, tenderness, juiciness, water-holding capacity, and marble of pork. Therefore, it is of great significance to study the mechanism of porcine IMF deposition. Previous research indicated that miR-149-5p promoted the proliferation of porcine intramuscular (IM) preadipocytes and decreased their ability to differentiate, albeit the exact mechanism of action is unknown. In vitro experiments, miR-149-5p had the opposite trend of fat deposition in Queshan Black and foreign pigs. The present study conducted transcriptomics and metabolomics analyses of porcine IM preadipocytes overexpressing miR-149-5p to verify their effects on lipid formation. According to metabolomics analysis, the overexpression of miR-149-5p significantly changed the lipid, organic acid, and organic oxygen metabolites of porcine IM preadipocytes. The overexpression of miR-149-5p significantly changed 115 metabolites, including 105 up-regulated and 10 down-regulated ones, and significantly changed the composition of lipid, organic acid, and organic oxygen metabolism-related metabolites. RNA-seq analysis showed that overexpression of miR-149-5p significantly altered 857 genes, of which 442 were up-regulated, and 415 were down-regulated, with enrichment to MAPK, IL-17, PI3K-Akt, and ErbB signaling pathways. In addition, the overexpression of miR-149-5p may affect the transport of Cu2+ by targeting ATP7A and inhibiting fat differentiation. These findings elucidate the regulatory function of miR-149-5p in porcine IM preadipocytes, which may be a key target for controlling pork quality.
Identification and validation of a DNA methylation-driven gene-based prognostic model for clear cell renal cell carcinoma
Authors: Deng Qiong , Du Ye , Wang Zhu , Chen Yeda , Wang Jieyan , Liang Hui , Zhang Du 
Published: February 2023

Abstract

Background:Clear cell renal cell carcinoma (ccRCC) is a malignant tumor with heterogeneous morphology and poor prognosis. This study aimed to establish a DNA methylation (DNAm)-driven gene-based prognostic model for ccRCC.Methods:Reduced representation bisulfite sequencing (RRBS) was performed on the DNA extracts from ccRCC patients. We analyzed the RRBS data from 10 pairs of patient samples to screen the candidate CpG sites, then trained and validated an 18-CpG site model, and integrated the clinical characters to establish a Nomogram model for the prognosis or risk evaluation of ccRCC.Results:We identified 2262 DMRs in the promoter region. After DMR selection, 578 candidates were screened, and was correspondence with 408 CpG dinucleotides in the 450K array. We collected the DNAm profiles of 478 ccRCC samples from TCGA dataset. Using the training set with 319 samples, a prognostic panel of 18 CpGs was determined by univariate Cox regression, LASSO regression, and multivariate Cox proportional hazards regression analyses. We constructed a prognostic model by combining the clinical signatures. In the test set (159 samples) and whole set (478 samples), the Kaplan-Meier plot showed significant differences; and the ROC curve and survival analyses showed AUC greater than 0.7. The Nomogram integrated with clinicopathological characters and methylation risk score had better performance, and the decision curve analyses also showed a beneficial effect.Conclusions:This work provides insight into the role of hypermethylation in ccRCC. The targets identified might serve as biomarkers for early ccRCC diagnosis and prognosis and as potential targets for ccRCC therapy.
Basin Dependence of the Tropical Cyclone Genesis Environment and the Future Changes Revealed by Machine Learning Methods
Authors: Jia Xiaojing , Qian Qifeng 
Published: February 2023

Abstract
Due to the limited data available and the lack of consensus on a tropical cyclone (TC) genesis theory, understanding the differences in TC genesis in different ocean basins is limited, and possible changes in TC genesis under the influence of future climate change are controversial. This study applies principal component analysis (PCA) to investigate the TC genesis environment in different ocean basins. The results show that the TC genesis environments are similar in all basins except the North Atlantic Ocean (NA). Compared with other basins, the TC genesis environment in the NA has a higher potential intensity (PI) and mid-level vertical velocity and a lower low and mid-level relative humidity. A maximum entropy (MaxEnt) model is established using various observational environmental variables and is subsequently transferred to the Coupled Model Intercomparison Project Phase 6 (CMIP6) model output to produce future projections of TC genesis. The MaxEnt model captures the unique TC genesis environment in the NA and predicts a more consistent decrease in the TC genesis probability in the 2100s under different future scenarios. A multivariate environmental similarity surface (MESS) analysis is applied to the CMIP6 model dataset, and it reveals that the CMIP6 model predicts the weakest change in the TC genesis environment in the NA compared to other ocean basins. Overall, our machine learning (ML) results suggest that the TC genesis environment in the NA has different characteristics compared to other ocean basins, and its TC genesis probability is projected, with high confidence, to decrease in the future using the CMIP6 models.
Identify a novel cuproptosis-related prognostic signature and build its ceRNA net and candidate medicine active ingredients in Pancreatic cancer
Authors: Huang Qilong , Li Guyu , Han Jiayu , Chang Shijie 
Published: February 2023

Abstract
Pancreatic cancer (PAAD) is a common malignancy that is difficult to diagnose and treat.Regulation of cell death plays an important role in tumorigenesis and is an important target of almost all therapeutic strategies. Various current studies have proved that various types of cell death patterns are closely related to the elimination of cancer.And here's the latest research is ”cuprotosis”.Cuproptosis is a novel form of programmed cell death, and its mechanism in tumours remains unclear.In the current study, we found that LIPT1、LIAS、DLD、DLAT、PDHA1 and PDHB in 10 differentially expressed CRGs were central genes.GO and KEGG enrichment results showed that these 10 CRGs were mainly enriched in Protein digestion and absorption、Pancreatic secretion、Human papillomavirus infection and Focal adhesion.We constructed a prognostic model based on the DLAT gene and showed good predictive potential.Clinical correlation analysis showed that DLAT was correlated with pathological stage and T stage of PAAD patients.Finally, we constructed a ceRNA network that may play a key role in the progression of PAAD and screened 12 compound active components that may regulate DLAT.This was verified by molecular docking.To sum up, we analyzed the potential value of DLAT gene in PAAD, constructed ceRNA network, and conducted targeted regulation of the active ingredients through comprehensive bioinformatics combined with experimental verification strategies.This work not only provides new insights into the treatment of PAAD, but also provides a basis for the development of new immunotherapeutic drugs targeting cuprotosis.
An Intuitionistic Fuzzy based Intelligent System for Semantic Interoperability and Privacy Preservation in Healthcare Systems
Authors: P Sony , G Siva Shanmugam , Nagarajan SureshKumar 
Published: February 2023

Abstract
Secure semantic interoperability solutions are required in the age of the digital era as heterogeneous IoT medical devices increase, and these devices produce vast amounts of data daily. Since the data is enormous, the hospital could not keep the complete data collection on its hospital information server. The cloud often handles storage, and state-of-the-art privacy protection relies on reliable cloud servers. Even if the documents are encrypted, the server may still determine what is contained there. This study ensures healthcare data privacy using AES and ElGamal encryption techniques while maintaining semantic Interoperability. The suggested technique provides a mechanism for document decryption on the customer’s end. By the amalgamation of medical ontology UMLS and Intuitionistic Fuzzy logic, most linguistic issues, such as word sense disambiguation, identification of lexical variances, hypernymy-hyponymy issues, and meronymy-holonymy issues, are addressed in this work. Results show that the proposed method outperforms existing solutions.