bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplicações da saúde digital no cuidado obstétrico: impactos e perspectivas que extrapolam a pandemia de COVID-19
Authors: Perez Murilo Pissinati , Oliveira Nathália Cristian Ferreira de , Reis Zilma Silveira Nogueira 
Published: July 2023

Introdução: O bem-estar da mulher em uma visão integral do cuidado à saúde feminina, exemplificado pelo cuidado obstétrico e atenção pré-natal, se respalda no acesso aos serviços de saúdes e à informação de qualidade, o que aumenta o empoderamento feminino, reduz complicações e os índices de mortalidade materno-fetais. Impulsionados pelo período de pandemia COVID-19, diversos sistemas informatizados têm se tornado aliados no cuidado à saúde da mulher e ao desenvolvimento da gestação, sendo a telemedicina e os aplicativos em saúde pilares importantes da e-Saúde que facilitam a interface médico-gestante.
Objetivo: Levantar evidências científicas na literatura sobre os impactos da implementação de sistemas de saúde digital na promoção de saúde e atenção à gestante durante o cuidado pré-natal e a validação da informação gerada pela gestante.
Método: Foram utilizadas as bases de dados PubMed, Scielo, Google Scholar e BVS no período de 2016 a 2021, com descritores em português e inglês, incluindo artigos de revisão, meta-análises, coortes prospectivas e retrospectivas, assim como os relatos de caso.
Resultado e Discussão: Foram selecionados 13 artigos e analisados sob a perspectiva de três grandes áreas envolvidas na aplicação da saúde digital ao cuidado obstétrico, dentre as quais a validação da informação da gestante constitui uma ferramenta de fomento às políticas públicas e pesquisas epidemiológicas, sendo a qualidade dessa informação e a participação ativa da gestante pilares importantes para a promoção de saúde materna-infantil; ademais, aplicativos educativos em saúde tem sido uma das formas informatizadas pela qual a telemedicina se populariza dentre os pacientes, inclusive como meio intervencionista nas relações médico-paciente. Assim, ferramentas de saúde obstétrica como o pré-natal se tornaram mais acessíveis e diversificadas, mesmo em um período de pandemia, por meio da e-Saúde. Por fim,o plano de parto mostra-se uma ferramenta eficaz no pré-natal, facilitando a comunicação da gestante com a equipe médica, familiares e amigos acerca das suas preferências quanto ao processo de parto, estimulando a mulher a ser protagonista de seu parto, humanizando-o.
Conclusão: A análise das publicações avaliadas apontam que as tecnologias de informação na área de saúde obstétrica permitem um cuidado integral e próximo por meios eletrônicos como aplicativos digitais, melhorando a atenção e diminuindo barreiras de acesso aos serviços de saúde. Aliadas a um plano de parto consolidado e informatizado, além de partilharem conteúdos educativos, ainda potencializam o poder de decisão feminino.
Genetics of Pulmonary Pressure and Right Ventricle Stress Identify Diabetes as a Causal Risk Factor
Authors: Bagheri Minoo , Agrawal Vineet , Annis Jeffrey , Shi Mingjian , Ferguson Jane F. , Freiberg Matthew S. , Mosley Jonathan D. , Brittain Evan L. 
Published: July 2023

Background
Epidemiologic studies have identified risk factors associated with pulmonary hypertension and right heart failure, but causative drivers of pulmonary hypertension and right heart adaptation are not well known. We sought to leverage unbiased genetic approaches to determine clinical conditions that share genetic architecture with pulmonary pressure and right ventricular dysfunction.

Methods and Results

We leveraged Vanderbilt University's deidentified electronic health records and DNA biobank to identify 14 861 subjects of European ancestry who underwent at least 1 echocardiogram with available estimates of pulmonary pressure and right ventricular function. Analyses of the study were performed between 2020 and 2022. The final analytical sample included 14 861 participants (mean [SD] age, 63 [15] years and mean [SD] body mass index, 29 [7] kg/m
2
). An unbiased phenome‐wide association study identified diabetes as the most statistically significant clinical
International Classifications of Diseases
,
Ninth Revision
(
ICD‐9
) code associated with polygenic risk for increased pulmonary pressure. We validated this finding further by finding significant associations between genetic risk for diabetes and a related condition, obesity, with pulmonary pressure estimate. We then used 2‐sample univariable Mendelian randomization and multivariable Mendelian randomization to show that diabetes, but not obesity, was independently associated with genetic risk for increased pulmonary pressure and decreased right ventricle load stress.

Conclusions
Our findings show that genetic risk for diabetes is the only significant independent causative driver of genetic risk for increased pulmonary pressure and decreased right ventricle load stress. These findings suggest that therapies targeting genetic risk for diabetes may also potentially be beneficial in treating pulmonary hypertension and right heart dysfunction.
Cigarette Smoking as a Risk Factor for Hematoma Expansion in Primary Intracerebral Hemorrhage: Analysis From a Randomized Clinical Trial
Authors: Schupper Alexander J. , Khorasanizadeh Mirhojjat , Rossitto Christina P. , Foster Lydia D. , Kellner Christopher P. , Suarez Jose I. , Qureshi Adnan I. , Majidi Shahram , Qureshi Adnan I. , Palesch Yuko Y. , Martin Renee L. , Barsan William G. , Silbergleit Robert , Hanley Daniel F. , Moy Claudia S. , Hsu Chung Y. , Steiner Thorsten , Suarez Jose I. , Toyoda Kazunori , Wang Yongjun , Yamamoto Haruko , Yoon Byung‐Woo 
Published: July 2023

Background
Cigarette smoking is a well‐known risk factor for ischemic and hemorrhagic stroke. We evaluated the impact of smoking status on hematoma expansion and clinical outcome in patients with primary intracerebral hemorrhage.

Methods and Results
This is a post hoc exploratory analysis of the ATACH (Antihypertensive Treatment at Acute Cerebral Hemorrhage)‐2 trial. Patients with intracerebral hemorrhage were randomized into intensive blood pressure lowering (systolic blood pressure, <139 mm Hg) versus standard blood pressure lowering (systolic blood pressure, 140–179 mm Hg) in this study. We compared the demographic characteristics; hematoma size, location, and expansion rate; and clinical outcome based on subjects' smoking status. Of a total of 914 patients in the trial with known smoking status, 439 (48%) patients were ever smokers (264 current smokers and 175 former smokers). Current and former smokers were younger and more likely to be men. Baseline Glasgow Coma Scale score and initial hematoma size did not vary based on smoking status. Ever smokers had higher rates of thalamic hemorrhage (42% versus 34%) and intraventricular hemorrhage (29% versus 23%); this rate was highest among former smokers versus current smokers (49% versus 35%, respectively). Ever smokers had a higher rate of hematoma expansion in 24 hours (adjusted relative risk [RR] [95% CI], 1.46 [1.08–1.96]) compared with nonsmokers on multivariate analysis. There was no significant difference in the rate of death and disability at 90 days between the 2 groups (adjusted RR [95% CI], 1.18 [0.998–1.40]).

Conclusions
Our analysis demonstrates cigarette smoking as an independent predictor for hematoma expansion. There was no significant difference in death and disability based on smoking status.
Regional Borders, Commuting and Transport Network Integration
Authors: Loumeau Gabriel 
Published: July 2023

Abstract
This paper exploits spatial quasi-experimental variation around French departmental borders to provide novel evidence that regional borders disturb surrounding economic activity; namely, commuting flows, catchment areas, and residential density. The lack of integration of local transport networks at regional borders – leading to a 4.5km travel distance penalty when crossing borders – explains the observed border effects. Using a spatial quantifiable equilibrium framework and accounting for construction costs, a policy simulation exercise shows that integrating local transport networks leads to a 6.36% average growth in real per capita residential income.
Financial Constraints, Sectoral Heterogeneity, and the Cyclicality of Investment
Authors: Howes Cooper 
Published: July 2023

Abstract
While investment in most sectors declines in response to a contractionary monetary policy shock, investment in the manufacturing sector increases. Using manually digitized aggregate income and balance sheet data for the universe of US manufacturing firms, I show this increase is driven by the types of firms which are least likely to be financially constrained. A two-sector New Keynesian model with financial frictions can match these facts; unconstrained firms take advantage of the decline in the user cost of capital caused by the monetary contraction, while constrained firms are forced to cut back. Removing firm financial constraints in the model dampens the response of manufacturing output to monetary shocks by about 25%.
Is the Patent System Sensitive to Incorrect Information?
Authors: Freilich Janet , Kim Soomi 
Published: July 2023

Abstract
We investigate whether participants in the patent system are sensitive to information quality by examining how they treat inaccurate information. We use a novel approach to identify patents with inaccurate information: patent-paper pairs where the paper has been retracted and the corresponding patent contains the retracted material. Despite containing inaccurate information, we find that these patents are prosecuted and maintained by many applicants, are not rejected by examiners, and continue to be cited by some downstream readers after retraction. Insensitivity to inaccurate information may lead to erroneous decisions during examination and has implications for patent quality, disclosure, and knowledge flows.
Fluoralforsite, Ba5(PO4)3F – a new apatite-group mineral from the Hatrurim Basin, Negev Desert, Israel
Authors: Krzątała Arkadiusz , Skrzyńska Katarzyna , Cametti Georgia , Galuskina Irina , Vapnik Yevgeny , Galuskin Evgeny 
Published: July 2023

AbstractFluoralforsite, ideally Ba5(PO4)3F, (space group P63/m (#176), Z = 2, a = 10.0031(2) Å, c= 7.5382(2) Å and V = 653.23(3) Å3), is a new mineral species of the apatite group – a Ba-analogue of fluorapatite and a F-analogue of alforsite. It was discovered in rankinite paralava filling cracks in pyrometamorphic gehlenite hornfels near the tributary of wadi Zohar and Gurim Anticline, Hatrurim Basin, Negev Desert, Israel. Fluoralforsite occurs in small intergranular spaces between large gehlenite and garnet crystals and in enclaves inside large rankinite crystals with other Ba minerals such as walstromite, zadovite, bennesherite, gurimite, mazorite, barioferrite and baryte. It forms tiny transparent, colourless crystals up to 50 μm with a white streak and a vitreous lustre. The cleavage was not observed. It exhibits a brittle tenacity and a conchoidal fracture. The estimated Mohs hardness is 4–4½, and its calculated density is 4.57 g/cm–3. Fluoralforsite is uniaxial (–) with refractive indices (589 nm) nω = 1.689(3) and nɛ = 1.687(3). The empirical crystal-chemical formula for the holotype calculated on the basis of 8 cations is: (Ba3.81Ca0.97Na0.07K0.05Sr0.05Fe0.05)Σ5(P5+2.32V5+0.29S6+0.22Si0.17)Σ3O12(F0.85Cl0.13)Σ0.98. The crystal structure was refined from single-crystal X-ray diffraction data with R1 = 0.0192. The structural investigation indicated an ordered arrangement of Ba/Ca at the M1 site within individual columns running along the c-axis, but a disordered distribution among adjacent columns throughout the structure, which enables the maintenance of the P63/m space group. Fluoralforsite was formed at the final stage of crystallisation as a result of a reaction between the primary mineral assemblages and residual melt.
Palaeomagnetic and mineral magnetic analyses of the Deckenschotter of northern Switzerland and southern Germany
Authors: Scheidt Stephanie , Buechi Marius W. , Egli Ramon , Biedermann Andrea R. , Deplazes Gaudenz 
Published: July 2023

AbstractThe Deckenschotter is a fluvial to glaciofluvial gravel unit in northern Switzerland and southern Germany. The deposits are considered the oldest preserved glacial to interglacial Quaternary deposits in the northern Alpine foreland and are thus important geomorphological markers for landscape evolution. Nevertheless, the age of the deposits is only approximately known and subject to controversial debates. This study presents the results of an extensive palaeomagnetic investigation carried out on intercalated fine-grained sediments at 11 sites of the Höhere Deckenschotter (HDS) and at 5 sites of the Tiefere Deckenschotter (TDS). The HDS show reversed and normal magnetisations, indicating deposition > 0.773 Ma, while the TDS exhibit only normal directions. Age constraints for the different sites are discussed in the light of evidence from other studies. The study therefore clearly supports the efforts to determine the age of the Deckenschotter. As data from previous palaeomagnetic studies on the HDS and TDS have not been published or preserved, this is in fact the only data-based palaeomagnetic study available.
Effect of a nitrogenous nanocomposite on leaching and N content in lettuce in soil columns
Authors: Rojas-Velázquez Ángel N. , Guillén-Castillo Oscar I. , Alcalá-Jauregui Jorge A. , Loredo-Osti Catarina , Ramírez-Tobías Hugo M. , Romero-Méndez Mauricio J. , Méndez-Cortés Heriberto , Hernández-Montoya Alejandra 
Published: July 2023

AbstractNanofertilizers could promote nutrient efficiency with slow release compared to conventional fertilizers (CF). Most of the applied nitrogen is lost on the soil by leaching, due to the rapid release behavior of CF. Clays can function as a nanosized porous structure to retain and slowly release nutrients. The objective of this study was to evaluate a nitrogenous nanocomposite (NCN) and its effect on leaching and N content of lettuce (Lactuca sativa). The treatments applied were: 100% conventional fertilizer, 100% nitrogenous nanocomposite and the mixture in percentage of CF/NCN 25/75, 50/50, 75/25 and 25/0, 50/0 75/0% on columns of soil with lettuce for 45 days. Leachates at the end of the cycle increased in treatments with NCN. Treatments with NCN have higher N content in the leaf. In regard to biomass growth, leaf area, leaf N, drained variables, electrical conductivity and NO3− content, it was possible to show that the doses of 50 and 75% of NCN match the characteristics of the crop compared to the control, which allows us to use lower doses than those recommended with CFs.
Biofilms and their role on diseases
Authors: Gondil Vijay Singh , Subhadra Bindu 
Published: July 2023

AbstractBiofilms are complex, three-dimensional structures that provide a long-established survival mechanism for microorganisms. Biofilms play a substantial role in pathogenesis as they can evade the immune response and be highly resistant to conventional antimicrobials, thus impacting the human health and healthcare system. To address this issue, BMC Microbiology invites submissions to the collection ‘Biofilms and its impact on disease’.
Effects of targeted mild hypercapnia versus normocapnia on cerebral oxygen saturation in patients undergoing laparoscopic hepatectomy under low central venous pressure: a prospective, randomized controlled study
Authors: Lv Huayan , Xiong Chang , Wu Bo , Lan Zhijian , Xu Duojia , Duan Dingnan , Huang Xiaoxia , Guo Jun , Yu Shian 
Published: July 2023

Abstract
Background
Laparoscopic hepatectomy under low central venous pressure (LCVP) is associated with intraoperative organ hypoperfusion, including cerebral hypoperfusion. We hypothesized that a ventilation strategy designed to achieve targeted mild hypercapnia (TMH) (end-tidal carbon dioxide partial pressure [PetCO2] of 45 ± 5 mmHg) rather than targeted normocapnia (TN) (PetCO2 of 30 ± 5 mmHg) would increase regional cerebral oxygen saturation (rSO2) during laparoscopic hepatectomy under LCVP.

Methods
Eighty patients undergoing laparoscopic hepatectomy under LCVP were randomly divided into the TMH group (n = 40) and the TN group (n = 40). Mechanical ventilation was adjusted to maintain the PetCO2 within the relevant range. Cerebral oxygenation was monitored continuously using the FORE-SIGHT system before anesthetic induction until the patient left the operating room. Patient and surgical characteristics, rSO2, intraoperative hemodynamic parameters (CVP, mean artery blood pressure [MAP], and heart rate), PetCO2, intraoperative blood gas analysis results, and postoperative complications were recorded.

Results
No significant differences were observed in CVP, MAP, and heart rate between the two groups during surgery. The rSO2 was significantly lower in the TN group on both the left and right sides during the intraoperative period (P < 0.05), while the TMH group had a stable rSO2. In the TN group, the mean rSO2 decreased most during liver parenchymal transection when compared with the baseline value (P < 0.05). The mean (standard deviation) percentage change in rSO2 from baseline to parenchymal transection was − 7.5% (4.8%) on the left and − 7.1% (4.6%) on the right. The two groups had a similar incidence of postoperative complications (P > 0.05).

Conclusion
Our findings demonstrate that rSO2 is better maintained during laparoscopic hepatectomy under LCVP when patients are ventilated to a PetCO2 of 45 ± 5 mmHg (TMH) than a PetCO2 of 30 ± 5 mmHg (TN).

Trial registration
ChiCTR2100051130(14/9/2021).
The predictive value of relative wall thickness on the prognosis of the patients with ST-segment elevation myocardial infarction
Authors: Zhang Ying , Qiao Shuaihua , Hao Han , Li Qiaoling , Bao Xue , Wang Kun , Gu Rong , Li Guannan , Kang Lina , Wu Han , Wei Zhonghai 
Published: July 2023

Abstract
Objective
The study aimed to evaluate the prognostic value of relative wall thickness (RWT) in the patients with ST-segment elevation myocardial infarction (STEMI).

Methods
A total of 866 patients with STEMI admitted in Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School from November 2010 to December 2018 were enrolled in the current study retrospectively. Three methods were used to calculate RWT: RWTPW, RWTIVS+PW and RWTIVS. The included patients were divided according to the median values of RWTPW, RWTIVS+PW, and RWTIVS, respectively. Survival analysis were performed with Kaplan–Meier plot and multivariate Cox proportional hazard model was established to evaluate the adjusted hazard ratio of the three kinds of RWT for all cause death, cardiac death and MACE (major adverse cardiac death).

Results
There was no significance for the survival analysis between the low and high groups of RWTPW, RWTIVS+PW and RWTIVS at 30 days and 12 months. Nonetheless, the cumulative incidence of all cause death and cardiac death in the low group of RWTPW and RWTIVS+PW was higher than those in the high group at 60 months. The cumulative incidence of MACE in the low group of RWTPW was higher than the high group at 60 months. Multivariate Cox regression model showed that RWTPW were inversely associated with long-term cardiac death and MACE in STEMI patients. In the subgroup analysis, three calculations of RWT had no predictive value for the patients with anterior myocardial infarction. By contrast, RWTPW was the most stable independent predictor for the long-term outcomes of the patients with non-anterior myocardial infarction.

Conclusion
RWTPW, RWTIVS+PW and RWTIVS had no predictive value for the long-term clinical outcomes of patients with anterior myocardial infarction, whereas RWTPW was a reliable predictor for all cause death, cardiac death and MACE in patients with non-anterior myocardial infarction.
Methylated SEPT9 combined with AFP and PIVKA-II is effective for the detection of HCC in high-risk population
Authors: Zheng Kepu , Dai Leiyang , Zhao Yingpeng , Li Laibang , Li Wang , Zhang Xibing , Su Qiuming , Wu Ruichao , Jiang Yizhou , Chen Yonglin , Ran Jianghua 
Published: July 2023

Abstract
Background
The methylation SEPT9 (mSEPT9) appeared to be effective for hepatocellular carcinoma (HCC) detection. However, its performance in high-risk population has not been validated. We designed a pilot study and aimed to investigate the performance of mSEPT9, AFP, PIVKA-II and their combination in hepatic cirrhosis (HC) population.

Methods
A training cohort was established including 103 HCC and 114 HC patients. 10 ml blood was collected from each patient with K2EDTA tubes, and 3–4 ml plasma was extracted for subsequent tests. The performance of mSEPT9, AFP, PIVKA-II and their combination was optimized by the training cohort. Test performance was prospectively validated with a validation cohort, including 51 HCC and 121 HC patients.

Results
At the optimal thresholds in the training cohort, the sensitivity, specificity and area under curve (AUC) was 72.82%, 89.47%, 0.84, and 48.57%, 89.92%, 0.79, and 63.64%, 95.95%, 0.79 for mSEPT9, AFP and PIVKA-II, respectively. The combined test significantly increased the sensitivity to 84.47% (P < 0.05) at the specificity of 86.84% with an AUC of 0.91. Stage-dependent performance was observed with all single markers and their combination in plasma marker levels, positive detection rate (PDR) and AUC. Moderate correlation was found between mSEPT9 and AFP plasma levels (r = 0.527, P < 0.0001). Good complementarity was found between any two of the three markers, providing optimal sensitivity in HCC detection when used in combination. Subsequent validation achieved a sensitivity, specificity and AUC of 65.31%, 92.86%, 0.80, and 44.24%, 89.26%, 0.75, and 62.22%, 95.27%, 0.78 for mSEPT9, AFP and PIVKA-II, respectively. The combined test yielded a significantly increased sensitivity of 84.00% (P < 0.05) at 85.57% specificity, with an AUC at 0.89.

Conclusions
The performance was optimal by the combination of mSEPT9, AFP, PIVKA-II compared with any single marker, and the combination may be effective for HCC opportunistic screening in HC population.