bluuebunny/crossref_metadata_2025_split huggingface dataset:
Down-regulation of ALDOB during metabolic reprogramming mediates malignant behavior in hepatocellular carcinoma and insensitivity to postoperative adjuvant transarterial chemoembolization
Authors: Xu Jing-Xuan , Qin Shui-Lin , Wei Hao-Wen , Chen Yuan-Yuan , Peng Yu-Chong , Qi Lu-Nan 
Published: February 2023

Abstract
Background: Postoperative transarterial chemoembolization (PA-TACE) is an effective adjuvant therapy for preventing early postoperative recurrence of hepatocellular carcinoma (HCC); however, many patients are insensitive to it. Therefore, the present study aimed to explore the in-depth reasons for PA-TACE resistance and provide a reliable basis for selecting patients who will benefit the most from PA-TACE.
Methods: The unique gene expression profiles of primary tumors from PA-TACE-sensitive or -insensitive patients were analyzed using microarray data. Combined differential expression analysis, gene set enrichment analysis (GSEA), and weighted correlation network analysis (WGCNA) were used to screen for potential drivers of PA-TACE insensitivity. The expression of ALDOB was silenced or overexpressed in hepatoma cell lines, and changes in glycolytic activity, cycle, apoptosis, and malignant biological phenotypes were observed under normoxia and hypoxia. Finally, an animal model was constructed to verify the effects of ALDOB dysregulation on the tumorigenic ability of HCC cells in vivo.
Results: The inhibition of ALDOB promoted the up-regulation of Ki67 expression, and glycolytic activity was significantly enhanced. Moreover, the proliferation, invasion, and migration capabilities were increased in HCC cells and even worse in hypoxia. This advantage of malignant behavior was also validated using in vivo models.
Conclusion: Down-regulation of ALDOB may underlie the metabolic reprogramming observed in HCC by promoting the malignant behavior of HCC cells. Hypoxia and ALDOB down-regulation acted additively, which was closely related to PA-TACE insensitivity. The use of ALDOB and Ki67 as a combined marker has the potential to identify the ‘PA-TACE beneficiary population’.
A Longitudinal Investigation of Code-Related Emergent Literacy Skills in Children Who Are Deaf and Hard of Hearing Across the Preschool Years
Authors: Werfel Krystal L. , Reynolds Gabriella , Fitton Lisa 
Published: February 2023

Purpose:
The purpose of this longitudinal investigation was to compare the developmental trajectories of code-related emergent literacy skills of children who are deaf and hard of hearing (DHH) who use amplification and spoken language across the preschool years.

Method:
Thirty children who are DHH and 31 children with typical hearing completed a language and emergent literacy assessment at 6-month intervals from age 4 through 6 years. Growth curve analysis was used to compare developmental trajectories between groups of the code-related skills of phonological awareness, phonological memory, phonological recoding, alphabet knowledge, and conceptual print knowledge.

Results:
Growth across the preschool years was observed on all code-related emergent literacy skills across groups. Children who are DHH scored consistently lower than children with typical hearing on phonological awareness, phonological memory, and conceptual print knowledge; no group differences were observed for phonological recoding or alphabet knowledge. No interactions of time and group were significant.

Conclusions:
Children who are DHH exhibit consistent deficits in phonological awareness, phonological memory, and conceptual print knowledge across the preschool years and begin formal literacy instruction with a weaker foundation in emergent literacy skills. Future work should focus on optimizing emergent literacy interventions for children who are DHH during the preschool years.

Supplemental Material:

https://doi.org/10.23641/asha.21998153
A Clinician's Guide to Critically Appraising Randomized Controlled Trials in the Field of Speech-Language Pathology
Authors: Donohue Cara , Carnaby Giselle , (Focht) Garand Kendrea L. 
Published: February 2023

Purpose:
When considering original research articles, randomized controlled trials (RCTs) provide the highest level of research evidence. Given this, RCTS are often used by clinicians performing evidence-based practice to determine the most effective intervention for a specific patient or patient population. Although RCTs represent a high level of research evidence, it is important for clinicians to critically appraise RCTs to determine the validity of the study methods deployed, the statistical and clinical significance of treatment effects, and whether or not the results generalize to a particular patient, patient population, and/or clinical setting. Therefore, this tutorial will provide clinicians with an overview of what an RCT is, the various types of RCTs, when RCTs are appropriate to conduct and/or use to inform clinical practice, and the advantages and limitations of RCTs. Additionally, this tutorial will provide clinicians with practical tools to employ when reading an RCT, including checklists with questions, definitions of important terminology frequently used in RCTs, and demonstrations of how to critically appraise RCTs using literature examples from the speech-language pathology literature.

Conclusions:
Learning how to interpret and apply the results from RCTs to inform clinical practice for purposes of improving patient care is a critical evidence-based practice skill for clinicians to develop. This tutorial will assist clinicians in the field of speech-language pathology by furthering their fundamental knowledge of RCTs and by providing them with pragmatic tools to critically appraise RCTs to inform their clinical practice.
What Predicts Individual Response to Language Treatment in Bilingual Children With Developmental Language Disorder?
Authors: Ebert Kerry Danahy , Pham Giang T. 
Published: February 2023

Purpose:
For bilingual children with developmental language disorder (DLD), language treatment response is the degree to which an individual child progresses in both of their languages. Understanding what predicts language treatment response for an individual child can help clinicians plan treatment more effectively.

Method:
This study is a retrospective analysis of data from the study of Ebert et al. (2014). Participants included 32 school-age Spanish–English bilingual children with DLD who completed an intensive language treatment program. Gains in Spanish and English were measured using raw test scores in each language. Predictors of language gains include language, cognitive, and demographic variables. To examine which predictors were significant, we calculated partial correlations between the potential predictors and the posttreatment language test scores, controlling for the effects of pretreatment test scores.

Results:
In Spanish, several predictors correlated with the outcome measures. After controlling for pretreatment scores, English grammaticality, female sex, processing speed, age, and fluid reasoning were related to Spanish posttreatment scores. In English, correlations with individual predictors were minimal. After controlling for pretreatment scores, only one variable was associated with one English posttreatment score: English grammaticality.

Conclusions:
The original study reported limited gains in Spanish compared to robust gains in English. Treatment response in Spanish is more variable given the lack of environmental support for Spanish in the United States. As a result, individual factors (including nonverbal cognition, pretreatment language levels, and demographic variables) influence treatment gains in Spanish. In contrast, strong environmental support for English supports a more consistent treatment response, with a smaller role for individual factors.

Supplemental Material:

https://doi.org/10.23641/asha.21991931
Various Control Strategies Performance Assessment of the DFIG wind turbine connected to a DC grid
Authors: Akhbari Allahyar , Rahimi Mohsen , Khooban Mohammad Hassan 
Published: February 2023

AbstractThis paper deals with the integration and control of the doubly fed induction generator‐based wind turbine (DFIG‐WT) in a DC grid. In this way, the stator of the DFIG‐WT is integrated with the DC grid via an uncontrolled diode‐bridge rectifier as well as a buck converter to provide a flexible connection path. In addition, the rotor of the DFIG‐WT exchanges power with the DC grid through a rotor‐side converter (RSC). By considering the DFIG‐WT system topology, three control strategies based on the stator flux‐oriented vector control are developed for the RSC and buck converter. The control schemes consist of the outer and the inner control loops with the proportional–integral (PI) controllers. Additionally, the stability of control strategies and their dependence on the generator parameters are evaluated and compared using modal analysis and numerical simulations in the MATLAB/SIMULINK environment. Finally, a real‐time hardware‐in‐the‐loop emulation‐based OPAL‐RT 5600 is accomplished to assess the performance of the superior control method from a practical perspective.
Delamination failure analysis of G10 insulator in electromagnetic rail launcher
Authors: Hu Xinkai , Lu Junyong , Tan Sai , Li Bai , Zhang Jiawei 
Published: February 2023

AbstractThe electromagnetic (EM) rail launcher G10 insulator is prone to delamination damage during launch, which affects the service life of the insulator. Through the secondary development of ABAQUS® commercial finite‐element software, an EM‐structure coupling launch dynamics model considering projectile‐barrel coupling is established. The simulation indicates that the transverse swing of the projectile changes in a sine‐like law, and the time of the upper half wave corresponds to the pulse width of the impact force pulse waveform. The stress concentration occurs on the inner surface of the insulator where the contact‐impact occurs, resulting in impact damage. The midline of the insulator inner surface bears a large compressive strain under the action of pre‐tightening force, and the insulator is compressed oscillatingly under the influence of the time‐varying load of the rail during launch. Under the condition of repeated launch, the launch package repeatedly impacts the insulator, and the alternating load of the rail is cyclically loaded on the insulator with impact damage, which will cause the compression fatigue of the insulator and the expansion of impact damage crack. They are the main reasons for the delamination failure of insulator, and the experimental analysis is carried out. This study provides a method to study the delamination failure mechanism of the insulator, and provides guidance for improving the life of the insulator.
A modified eye‐in‐hand stereo visual control for grasping unknown objects via Scara robot
Authors: Jeddi Mahmoud , Khoogar Ahmad Reza 
Published: February 2023

AbstractHere, the switch proportional integral derivative controller (PID) stereo image‐based visual servoing controller is designed for controlling the manipulator robots. The proposed control algorithm separates the rotational and translational motion of the camera, so the stereo image‐based visual servoing control could be decomposed into three separate stages with different gains. Despite the increasing computation and complexity of relationships, instead of kinematics, robot dynamics are used to guide the robot to make the simulation more consistent with the real condition. To reduce response time and improve the robot's trajectory, the object positions in the image space are predicted by the Extended Kalman filter. The results showed that the proposed method produces a more accurate response than the classical methods that use robot kinematics. Adding the trajectory estimation algorithm improves the time response of the system and its industrial application capabilities.
Wide band UV/Vis/NIR blazed-binary reflective gratings for spectro-imagers: two lithographic technologies investigation
Authors: Lee Mane-Si Laure , Cholet Julie , Delboulbé Anne , Guillemet Raphaël , Loiseaux Brigitte , Garabédian Patrick , Flügel-Paul Thomas , Benkenstein Tino , Sadlowski Susann , Tetaz Nicolas , Windpassinger Roman , Mateo Ana Baselga 
Published: February 2023

We report on subwavelength reflective gratings for hyperspectral applications operating in a very large spectral band (340–1040 nm). Our study concerns a blazed-binary grating having a period of 30 μm and composed of 2D subwavelength structures with size from 120 nm to 350 nm. We demonstrate the manufacturing of the gratings on 3″ wafers by two lithography technologies (e-beam and nanoimprint) followed by classical dry etching process. Optical measurements show that the subwavelength grating approach enables a broadband efficiency, polarization behaviour and wavefront quality improvement with respect to the requirements for the next generation of spectro-imagers for Earth observation missions. An outlook towards spherical substrate based on nanoimprint lithography is also reported with the results of mixed features replication (holes and pillars in the range of 160–330 nm) on a 540 mm concave substrate which demonstrate uniformity and accuracy capabilities over 3″ surface.
A Neonate with Mucopolysaccharidosis Type VII with Intractable Ascites
Authors: Fukui Kana , Amari Shoichiro , Yotani Nobuyuki , Kosaki Rika , Hata Kenichiro , Kosuga Motomichi , Sago Haruhiko , Isayama Tetsuya , Ito Yushi 
Published: February 2023

AbstractWe report a case of a patient with severe fetal hydrops and refractory ascites, diagnosed as mucopolysaccharidosis type VII (MPS VII) by whole-exome sequencing, and discharged at 5 months of age after long-term ventilatory management. A male neonate was born by emergency cesarean section due to fetal distress at 301/7 weeks' gestation. Physical examination and X-rays revealed pleural effusion, ascites, and generalized edema, indicating severe fetal hydrops. He underwent tracheal intubation because of respiratory distress that was attributed to massive ascites, pulmonary hypoplasia, and pulmonary hypertension. He received mechanical ventilation and inhaled nitric oxide therapy. Prednisone, octreotide, and a factor XIII preparation were used as the treatment for ascites, and the ascites gradually decreased. He was extubated within 2 months of age. At 4 months of age, the results of whole-exome sequencing of the cord blood showed a compound heterozygous mutation in the GUSB gene, the gene responsible for MPS VII. Enzyme replacement therapy was initiated, and the ascites was resolved. Careful systemic management, including lung-protective respiratory management and the early establishment of nutrition, is important for the long-term survival of infants with fetal hydrops, and early aggressive workup, including whole-genome sequencing for the cause, should be performed in the case of refractory ascites.
Multicenter retrospective cohort of EUS-guided anterograde pancreatic duct access
Authors: Motomura Douglas , Irani Shayan , Larsen Michael , Kozarek Richard A , Ross Andrew S , Gan S Ian 
Published: February 2023

Abstract
Background and study aims Pancreatic duct (PD) cannulation may be difficult during conventional endoscopic retrograde cholangiopancreatography (ERCP) due to underlying pathology, anatomical variants or surgically altered anatomy. Pancreatic access in these cases previously necessitated percutaneous or surgical approaches. Endoscopic ultrasound (EUS) allows for an alternative and can be combined with ERCP for rendezvous during the same procedure, or for other salvage options.
Patients and methods Patients with attempted EUS access of the PD from tertiary referral centers between 2009 and 2022 were included in the cohort. Demographic data, technical data, procedural outcomes and adverse events were collected. The primary outcome was rendezvous success. Secondary outcomes included rates of successful PD decompression and change in procedural success over time.
Results The PD was accessed in 105 of 111 procedures (95 %), with successful subsequent ERCP in 45 of 95 attempts (47 %). Salvage direct PD stenting was performed in 5 of 14 attempts (36 %). Sixteen patients were scheduled for direct PD stenting (without rendezvous) with 100 % success rate. Thus 66 patients (59 %) had successful decompression. Success rates improved from 41 % in the first third of cases to 76 % in the final third. There were 13 complications (12 %), including post-procedure pancreatitis in seven patients (6 %).
Conclusions EUS-guided anterograde pancreas access is a feasible salvage method if retrograde access fails. The duct can be cannulated, and drainage can be achieved in the majority of cases. Success rates improve over time. Future research may involve investigation into technical, patient and procedural factors contributing to rendezvous success.
Not All Postoperative Stridor in Infants Is Due to Endotracheal Tube-Induced Subglottic Edema
Authors: Mariappan Ramamani , Ninan Rebecca A. , Raju Krishnaprabhu 
Published: February 2023

AbstractA 6-month-old infant presented with clinicoradiological features of a shunt dysfunction. Magnetic resonance imaging brain showed multiple leptomeningeal cysts in the posterior fossa, with the largest in the right cerebellopontine (CP) angle cistern causing compression on the brain stem and fourth ventricle. There was gross hydrocephalus with the malpositioned shunt tube. He underwent shunt revision followed by right retromastoid craniectomy and decompression of the right CP angle cyst. Following extubation, he developed stridor that was diagnosed initially as subglottic edema and treated with humidified oxygen, systemic corticosteroids, and nebulized adrenaline. Failure to resolve the symptoms warranted a video laryngoscopy that revealed right vocal cord palsy (VCP), and he was reintubated. He was started on steroids and got extubated on a nasal continuous positive airway pressure and was gradually weaned off. Intraoperative handling of the vagus nerve while decompressing the cyst led to a right VCP, which was communicated later to the anesthesiologist. Neurological cause and association need to be considered as one of the differentials while managing postoperative stridor after posterior fossa surgery in an infant. Timely communication between the surgeon and anesthesiologist is paramount for reducing morbidity.
On the algebraic approach to GUP in anisotropic space
Authors: Herkenhoff Gomes André 
Published: February 2023

Abstract
Motivated by current searches for signals of Lorentz symmetry violation in nature and recent investigations on generalized uncertainty principle (GUP) models in anisotropic space, in this paper we identify GUP models satisfying two criteria: (i) invariance of commutators under canonical transformations, and (ii) physical independence of position and momentum on the ordering of auxiliary operators in their definitions. Compliance of these criteria is fundamental if one wishes to unambiguously describe GUP using an algebraic approach and, surprisingly, neither is trivially satisfied when GUP is assumed within anisotropic space. As a consequence, we use these criteria to place important restrictions on what or how GUP models may be approached algebraically.
Enhanced piezoelectric energy harvesting based on sandwiched phononic crystal with embedded spheres
Authors: Gantasala Subrahmanyam , Thomas Tiju , Rajagopal Prabhu 
Published: February 2023

Abstract
In recent years, metamaterial/ phononic crystal (PnC) based energy harvesters are gaining interest due to their excellent elastic wave manipulation and energy trapping capabilities. Here, we propose a novel PnC comprising of Tungsten Carbide (WC) spheres embedded in epoxy resin matrix. The sphere-epoxy composite is encapsulated by Aluminum (Al) holey structure and the device is sandwiched between two Al plates. Numerical analysis of band structure reveals a wide phononic band gap (BG) from 50.65 kHz to 71.12 kHz. These BGs can be engineered by varying geometric parameters of the unit cell viz., the radius of the sphere and thickness of Al plates. A point defect is introduced by removing the central sphere of the 5 × 5 PnC to facilitate the robust localization of evanescent wave defect modes within the bandgap. Moreover, it is observed that, by altering the radius of the defect sphere, the number of defect modes and their shift can be reconfigured. A PnC based energy harvester is implemented by attaching a piezoelectric disk (PZT-5H) onto the defect PnC just above the defect site. This arrangement of PZT disk converts the highly resonant mechanical defect mode into electrical energy, thereby allowing vibration energy harvesting. Finally, we show that the power enhancement can be achieved by ∼12 times with the proposed PnC compared to the bare Al block.
Simultaneous cooling coupled nano-mechanical resonators in cavity optomechanics
Authors: Li Ji-Xin , Ooi C H Raymond , Wang Qiong , Chang Sheng-Li 
Published: February 2023

Abstract
Coupled mechanical resonators have recently attracted great attention for both practical applications and fundamental studies. As a preparation step, it is needed to cool the coupled mechanical resonators to their ground states. Here we propose a theoretical scheme to cool two coupled mechanical resonators by introducing an optomechanical interface. The final mean phonon numbers of the two mechanical resonators are calculated exactly and the results show that the ground-state cooling is achievable in the resolved-sideband regime and under the optimal driving. Moreover, we derived analytical expressions of the cooling limits by adiabatically eliminating the cavity field under the large-decay limit.
Properties of Flare Events on M Stars from LAMOST Spectral Survey Based on Kepler and TESS Light Curves
Authors: Meng Gang , Zhang Li-Yun , Su Tianhao , Yang Zilu , Han Xianming L. , Misra Prabhakar , Long Liu , Pi Qingfeng , Zhu Zhongzhong , Jiang Linyan 
Published: February 2023

Abstract
A catalog of M stars has been published from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope data release 7 (LAMOST DR7). We cross-matched the LAMOST M catalog with Kepler, Kepler 2 (K2) and Transiting Exoplanet Survey Satellite (TESS) surveys. We obtained the light curves from the Kepler and TESS surveys. We detected 20,047 flare events from 4053 M stars and calculated their durations, amplitudes, and energies. We analyzed the distribution of the flare durations and energies. The distributions of flare duration for Kepler, K2 and TESS peak are at 3–3.5 hr, 4–6 hr and 1–1.5 hr, respectively. This may be the result of the different cadences for the three data sets. The highest regions of the flare energies of Kepler, K2 and TESS are 32–32.5, 32–32.5 and 31–31.5 erg in Log format, respectively. A linear relationship between flare duration and energy emerges from our analysis. The ratio of flare duration to total observational time is approximately 0.2%–0.3% for the Kepler, K2 and TESS surveys. The occurrence rate of a star with a flare event increases from the M0 to M4 subtypes. We also determined the spatial distribution of the flare rate of M stars in the Milky Way. It seems that the flare rate decreases as the vertical height increases. The power index of the flare energies is in the region of 1.53–2.32, which is similar to previous result for solar type star (2.0). Further, we examined the relationship between the flare amplitude and chromospheric intensity. The flare activity increases rapidly with the increase in the Hα EW at the lower values (less approximately 2 Å) and it increases slowly at the higher values.