bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network Communications Flexibly Predict Visual Contents That Enhance Representations for Faster Visual Categorization
Authors: Yan Yuening , Zhan Jiayu , Ince Robin A. A. , Schyns Philippe G. 
Published: June 2023

Models of visual cognition generally assume that brain networks predict the contents of a stimulus to facilitate its subsequent categorization. However, understanding prediction and categorization at a network level has remained challenging, partly because we need to reverse engineer their information processing mechanisms from the dynamic neural signals. Here, we used connectivity measures that can isolate the communications of a specific content to reconstruct these network mechanisms in each individual participant (N= 11, both sexes). Each was cued to the spatial location (left vs right) and contents [low spatial frequency (LSF) vs high spatial frequency (HSF)] of a predicted Gabor stimulus that they then categorized. Using each participant's concurrently measured MEG, we reconstructed networks that predict and categorize LSF versus HSF contents for behavior. We found that predicted contents flexibly propagate top down from temporal to lateralized occipital cortex, depending on task demands, under supervisory control of prefrontal cortex. When they reach lateralized occipital cortex, predictions enhance the bottom-up LSF versus HSF representations of the stimulus, all the way from occipital-ventral-parietal to premotor cortex, in turn producing faster categorization behavior. Importantly, content communications are subsets (i.e., 55–75%) of the signal-to-signal communications typically measured between brain regions. Hence, our study isolates functional networks that process the information of cognitive functions.SIGNIFICANCE STATEMENTAn enduring cognitive hypothesis states that our perception is partly influenced by the bottom-up sensory input but also by top-down expectations. However, cognitive explanations of the dynamic brain networks mechanisms that flexibly predict and categorize the visual input according to task-demands remain elusive. We addressed them in a predictive experimental design by isolating the network communications of cognitive contents from all other communications. Our methods revealed a Prediction Network that flexibly communicates contents from temporal to lateralized occipital cortex, with explicit frontal control, and an occipital-ventral-parietal-frontal Categorization Network that represents more sharply the predicted contents from the shown stimulus, leading to faster behavior. Our framework and results therefore shed a new light of cognitive information processing on dynamic brain activity.
The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs
Authors: Stier Anna , Gilberto Samuel , Mohamed Weaam I , Royall Lars N , Helenius Jonne , Mikicic Ivan , Sajic Tatjana , Beli Petra , Müller Daniel J , Jessberger Sebastian , Peter Matthias 
Published: June 2023

AbstractThe paralogs CUL4A and CUL4B assemble cullin‐RING E3 ubiquitin ligase (CRL) complexes regulating multiple chromatin‐associated cellular functions. Although they are structurally similar, we found that the unique N‐terminal extension of CUL4B is heavily phosphorylated during mitosis, and the phosphorylation pattern is perturbed in the CUL4B‐P50L mutation causing X‐linked intellectual disability (XLID). Phenotypic characterization and mutational analysis revealed that CUL4B phosphorylation is required for efficient progression through mitosis, controlling spindle positioning and cortical tension. While CUL4B phosphorylation triggers chromatin exclusion, it promotes binding to actin regulators and to two previously unrecognized CUL4B‐specific substrate receptors (DCAFs), LIS1 and WDR1. Indeed, co‐immunoprecipitation experiments and biochemical analysis revealed that LIS1 and WDR1 interact with DDB1, and their binding is enhanced by the phosphorylated N‐terminal domain of CUL4B. Finally, a human forebrain organoid model demonstrated that CUL4B is required to develop stable ventricular structures that correlate with onset of forebrain differentiation. Together, our study uncovers previously unrecognized DCAFs relevant for mitosis and brain development that specifically bind CUL4B, but not the CUL4B‐P50L patient mutant, by a phosphorylation‐dependent mechanism.
Aberrant DNA N6‐methyladenine incorporation via adenylate kinase 1 is suppressed by ADAL deaminase‐dependent 2′‐deoxynucleotide pool sanitation
Authors: Chen Shaokun , Lai Weiyi , Li Yanan , Liu Yan , Jiang Jie , Li Xiangjun , Jiang Guibin , Wang Hailin 
Published: June 2023

AbstractIntracellular decay of N6‐methyladenine (m6A)‐containing RNA potentially induces aberrant N6‐methyl‐2′‐adenine (6mdA) misincorporation into DNA. Biophysically, misincorporated 6mdA may destabilize the DNA duplex in a manner similar to bona fide methylated 6mdA DNA, thereby affecting DNA replication and transcription. Utilizing heavy stable isotope labeling and ultrasensitive UHPLC–MS/MS assay, we demonstrate that intracellular m6A‐RNA decay does not generate free 6mdA species, nor lead to any misincorporated DNA 6mdA in most mammalian cell lines tested, unveiling the existence of a sanitation mechanism that prevents 6mdA misincorporation. Depletion of deaminase ADAL increases the levels of free 6mdA species, concomitant with the presence of DNA‐misincorporated 6mdA resulting from intracellular RNA m6A decay, suggesting that ADAL catabolizes 6mdAMP in vivo. Furthermore, we show that the overexpression of adenylate kinase 1 (AK1) promotes 6mdA misincorporation, while AK1 knockdown diminishes 6mdA incorporation, in ADAL‐deficient cells. We conclude that ADAL together with other factors (such as MTH1) contributes to 2′‐deoxynucleotide pool sanitation in most cells but compromised sanitation (e.g., in NIH3T3 cells) and increased AK1 expression may facilitate aberrant 6mdA incorporation. This sanitation mechanism may provide a framework for the maintenance of the epigenetic 6mdA landscape.
Implementation of ESC QI Initiative in Neonatal Unit Setting and Adaptation During the Pandemic
Authors: Small Sarah , Pham Rachel , Turbenson Meghan , Coleman Zoe , Manuel Vinit , Muniraman Hemananda 
Published: June 2023

OBJECTIVES
To improve outcomes in infants with neonatal opioid withdrawal syndrome (NOWS) admitted to NICU by implementing a quality improvement (QI) initiative incorporating “eat, sleep, console” (ESC) as a withdrawal evaluation tool and promotion of nonpharmacological interventions. Secondarily, we evaluated the impact of the coronavirus disease 2019 pandemic on QI initiative and outcomes.

METHODS
We included infants born ≥ 36 weeks gestation and admitted to NICU with a primary diagnosis of NOWS between December 2017 and February 2021. (preintervention; December 2017–January 2019, postintervention; February 2019–February 2021). We compared cumulative dose, duration of opioid treatment, and length of stay (LOS) as our primary outcomes.

RESULTS
The average duration of opioid treatment decreased from 18.6 days in the preimplementation cohort (n = 36) to 1.5 days in the first-year postimplementation (n = 44) with a reduction in cumulative opioid dose from 5.8 mg/kg to 0.6 mg/kg and decrease in the proportion of infants treated with opioids from 94.2% to 41.1%. Similarly, the average LOS decreased from 26.6 to 7.6 days. In the second-year postimplementation during the coronavirus disease 2019 pandemic (n = 24), there was an increase in average opioid treatment duration and LOS to 5.1 and 12.3 days respectively, but cumulative opioid dose (0.8 mg/kg) remained significantly lower than the preimplementation cohort.

CONCLUSIONS
ESC-based quality improvement initiative led to a significant decrease in LOS and opioid pharmacotherapy in infants with NOWS in NICU setting. Despite the impact of the pandemic, some of the gains were sustained with adaptation to ESC QI initiative.
Coworking como Ambiente para a Exploração de Buracos Estruturais
Authors: Junior Luiz Oliveira , Costa Danilo De Melo 
Published: June 2023

O objetivo da presente pesquisa é investigar a predisposição para exploração de buracos estruturais em ambientes de coworking. No que se refere à metodologia, apresenta abordagem qualitativa e quantitativa. Na pesquisa quantitativa, os dados foram coletados por meio de questionários e usou-se de estatística descritiva, procedimentos de análise univariada e método de Bonferroni com alfa = 0.05. Em relação à pesquisa qualitativa, foram realizadas entrevistas semiestruturadas junto aos gestores de empresas instaladas em um ambiente de coworking localizado na cidade de Belo Horizonte, Minas Gerais e adotou-se a análise de conteúdo categorial. Os resultados evidenciaram a existência de buracos estruturais com oportunidade de exploração para empresas instaladas em um espaço de coworking. Assim, recomenda-se que gestores de espaços de coworking que busquem desenvolver estratégias gerenciais que visem incentivar contatos mais efetivos, especialmente os interorganizacionais, de forma a intensificar as relações, promover mais trocas de informações e, por consequência, superar os possíveis buracos estruturais existentes.
Arterial grafts for myocardial revascularization using the Y-composite grafts and the in situ internal thoracic artery conduits. The current status of the problem
Authors: Sabetov Azat K. , Sirota Dmitry A. , Hvan Dmitry S. , Akulov Vsevolod A. , Chernyavskiy Alexander M. 
Published: June 2023

HighlightsThe article outlines the modern concept of arterial myocardial revascularization, presents the most promising directions for development of coronary surgery, and describes the results and prospects of the clinical application of autogenous arterial grafts using two internal thoracic arteries in various graft configuration and in situ, making it possible to assess the effectiveness of the procedure. AbstractThere are many approaches to coronary artery bypass grafting with the internal thoracic arteries: the use of I and Y configuration, in situ grafts, and composite grafts. However, there is no consensus on the most effective type of configuration of arterial grafts. This is due to the complexity of making the composite Y graft, determination of the risk factor, and the lack of sufficient evidence regarding the main approaches to bypass grafting with autogenous arterial grafts.
ANEMIA AND LONG-TERM SURVIVAL OF PATIENTS AFTER MITRAL VALVE SURGERY
Authors: Matsuganov Denis A. , Nuzhdin Mikhail D. 
Published: June 2023

HighlightsThe authors have studied anemia`s impact on the long-term mortality after mitral valve surgery. The research results indicate the need to address this modifiable factor in the preoperative period. Aim. To analyze the impact of anemia on the long-term survival of patients after mitral valve surgery.Methods. The study included 103 patients, 46 of them were men, 57 were women. Thirteen patients presented with anemia before surgery, and 90 patients did not have anemia. The survival rate of patients was compared using the Kaplan-Meier estimate.Results. The survival rate after surgery in the group of patients without anemia was higher compared with patients with anemia (p = 0,002). By the end of the follow-up period, the survival rate among patients without anemia reached 50.2%, whereas among patients with anemia it was 0.0%.Conclusion. Anemia is an independent predictor of complications in the postoperative period in patients with low preoperative hemoglobin levels. According to the results, the presence of anemia increases the risk of adverse events by 7.71 times in the preoperative period. Moreover, patients without anemia had the highest (up to 50.2%) survival rate in the long-term period, while patients with anemia had a survival rate equal to 0.0%.
Mitral homograft in tricuspid position: indications for implantation and surgical technique
Authors: Komarov Roman N. , Nuzhdin Mikhail D. , Belov Vyacheslav A. , Chernyavsky Stanislav V. , Ismailbayev Alisher M. , Drakina Olga V. , Tsaregorodtsev Anton V. , Baziyants Lusine R. 
Published: June 2023

HighlightsThe article presents the latest data on the techniques of implantation of the mitral homograft in the tricuspid position, and identifies groups of patients who are best suited for this method. Moreover, the article describes the evolution of this type of replacement, and highlights that many surgical techniques, although justified, require further study to show demonstrate their advantages. AbstractDespite the general trend in cardiac surgery towards valve-preserving interventions, valve replacements remain relevant, and the search for the perfect prosthetic valve continues. Many believe that tricuspid valve replacement using a mitral homograft can be the method of choice in certain situations. The analysis of the studies found in the PubMed database led the authors to the following conclusions: most of the data on the use of this technique in patients with infective endocarditis (IE), other indications are congenital heart disease (CHD) and rheumatic heart disease. Patients with IE who have undergone tricuspid valve replacement using a mitral homograft have good medium-term prospects, and respond well to medical treatment of recurrent IE. The mitral homograft in the tricuspid position remains intact even after prosthetic endocarditis. In this regard, it is possible to perform reconstructive intervention in case of prosthetic valve dysfunction without the need for repeated replacement. Such interventions are relevant for patients with growing heart for whom annuloplasty at the first stage of surgery is undesirable. Moreover, it is also cost-effective due to the high cost and low availability of homografts. The possibility of repeated tricuspid valve-in-valve replacement is important for patients who may not survive open surgery. To date, there are not enough long-term and short-term data on using a mitral homograft for tricuspid valve replacement, however, it can be assumed that the results of this technique will be positive provided that the appropriate implantation technique and strict patient selection are ensured. Many authors have come to the conclusion that the optimal homograft implantation technique includes sewing of the graft`s papillary muscles into the wall of the myocardium of the right ventricle (RV), fixating them on the outer surface of the RV, anatomical positioning of the homograft (anterior leaflet faces towards the IVS), and the use of an annuloplasty ring.
Impact of preoperative cognitive impairment on changes in electrical activity of the brain in patients undergoing combined carotid endarterectomy and coronary artery bypass grafting
Authors: Tarasova Irina V. , Kupriyanova Darya S. , Trubnikova Olga A. , Sosnina Anastasia S. , Syrova Irina D. , Kukhareva Irina N. , Maleva Olga V. , Ivanov Sergey V. , Barbarash Olga L. 
Published: June 2023

HighlightsThe presence of preoperative mild cognitive impairment (MCI) in patients undergoing combined carotid endarterectomy and coronary artery bypass grafting is associated with an increased theta activity at the frontal and parieto-occipital regions of both hemispheres after surgery. AbstractAim. To study the impact of preoperative cognitive impairment on changes in electrical activity of the brain in patients undergoing combined carotid endarterectomy and coronary artery bypass grafting.Methods. Sixty-three patients undergoing combined carotid endarterectomy (CAE) and coronary artery bypass grafting (CABG) were included in the study. The patients were divided into three groups, depending on the preoperative cognitive functions: without cognitive impairment (n = 17), with MCI (n = 29), and with severe cognitive impairment (n = 17). High-resolution electroencephalography (EEG) (62 channels, bandpass filtered between 0.1–50.0 Hz, sampling rate of 1000 Hz) was performed 3–5 days before and 7–10 days after surgery.Results. Patients with severe cognitive impairment at baseline presented with higher theta activity at the frontal region of the left hemisphere compared to patients without cognitive impairment and patients with MCI (p = 0.048). At the same time, patients with MCI showed the most pronounced theta activity increase after surgery compared to preoperative levels at the frontal and parieto-occipital cortical regions of both the left and right hemispheres (p≤0.05). Postoperative changes of theta activity in patients with severe cognitive impairment were minimal and statistically insignificant.Conclusion. Patients without severe preoperative cognitive impairment presented with higher grade brain dysfunction in the form of increased theta activity at the frontal and parieto-occipital regions after combined CAE and CABG. A smaller decrease in theta power after surgery in patients with severe preoperative cognitive impairment, on the one hand, can indicate compensation after cerebral ischemia and resistance to hypoperfusion during on-pump cardiac surgery, and on the other, can be a manifestation of the ceiling effect and insufficiency of brain functional reserves.
AUTOGENOUS ARTERIAL GRAFTS FOR MYOCARDIAL REVASCULARIZATION USING THE Y-COMPOSITE GRAFTS AND THE IN SITU INTERNAL THORACIC ARTERY CONDUITS. THE CURRENT STATUS OF THE PROBLEM
Authors: Sabetov Azat K. , Sirota Dmitry A. , Hvan Dmitry S. , Akulov Vsevolod A. , Chernyavskiy Alexander M. 
Published: June 2023

HighlightsThe article outlines the modern concept of arterial myocardial revascularization, presents the most promising directions for development of coronary surgery, and describes the results and prospects of the clinical application of autogenous arterial grafts using two internal thoracic arteries in various graft configuration and in situ, making it possible to assess the effectiveness of the procedure. AbstractThere are many approaches to coronary artery bypass grafting with the internal thoracic arteries: the use of I and Y configuration, in situ grafts, and composite grafts. However, there is no consensus on the most effective type of configuration of arterial grafts. This is due to the complexity of making the composite Y graft, determination of the risk factor, and the lack of sufficient evidence regarding the main approaches to bypass grafting with autogenous arterial grafts.
Diabetic retinopathy prevention and treatment options
Authors: Santiago Gerardo Garcia , Gonzalez Guillermo Avalos , Velazquez Jose M. Huerta , Torres Jose Maria Zepeda , Curriel Alexa Jimenez 
Published: June 2023

The objective of this review article was to mention the prevalence and risk factors for diabetic retinopathy to occur. Also, mention and compare the best ways to prevent this complication. Adding also a comparison of the best currently available treatments for diabetic retinopathy. Diabetic retinopathy is the first cause of visual impairment in working-age adults worldwide. Duration of diabetes is a major risk factor associated with the development of diabetic retinopathy. Due to the large number of patients with type 2 diabetes, this group comprises a larger proportion of the disease burden in patients with visual impairment from diabetic retinopathy compared to patients with type 1 diabetes. Diabetic retinopathy is the most common cause of visual impairment and blindness in patients aged 20-74 years. Approximately 80% of the patients with type 1 diabetes will develop retinopathy after 15 years after the onset of the pathology. In the case of type 2 diabetes will develop retinopathy after 30 years of history with the disease. Some important factor that can accelerate the process is the use or not of insulin for treatment. The most important for the treatment of diabetic retinopathy is the prevention of the diabetes in healthy people that have the risk factor to develop this pathology. The best options of treatment continued to be the combination of anti-VEFG/panphotocoagulation depending the stage of the complication. Improvement of the early detection of this type of microvascular complication for give them an early treatment and improve the evolution in positive way. We believed that is need to investigate more techniques for early detections of microvascular complications of diabetes mellitus, like imagen or biomarkers.
Sustainability Reporting Trends: A Systematic Literature Network Analysis
Authors: Hyk Vasyl , Vysochan Oleh , Vysochan Olha 
Published: June 2023

Compiling and submitting sustainable development reports is a key area for reforming corporate reporting in light of the implementation of the Sustainable Development Goals. In recent years, the share of companies that report sustainable development and corporate social responsibility has grown significantly. Thus, the study of the definition of the conceptual apparatus is important. The article aims to study the quantitative and qualitative structure of the documentary flow of scientific periodicals, the main areas of research, and development trends and. It also presents the results of a systematic review of publications on “sustainability reporting”.
The study used bibliometric analysis of scientific periodicals from the Scopus scientometric database between 2011–2021. The scientific papers selected by the keyword “sustainability reporting” were exported for processing in the VOSviewer and R (bibliometrix package) computer programs. Based on the results of quantitative analysis, 625 publications were accepted, most of which were scientific articles. The main areas of research on sustainability reporting in accounting are sustainable development, sustainability, decision‑making, sustainability reporting, and accountability.
The study also made it possible to identify the authors and research schools that have made the most significant contribution to this topic, and to establish geographical clusters in the context of countries around the world that work closely with each other and the highest‑rated journals.
The originality of this study is that it helps to create a conceptual framework. It should guide the definition of future research, and it is designed to provide qualitative new insight into the role of sustainable development reporting. The article provides an opportunity to fill the gaps in quality research on sustainable development reporting. The main conclusions of this article will help researchers to expand their knowledge in this area through retrospective analysis of the research results.