bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of heart rate, aortic compliance and stroke volume on the aortic regurgitation fraction studied in an ex vivo pig model
Authors: Reil Jan Christian , Saisho Hiroyuki , Jockwer Antonia , Fujita Buntaro , Paluszkiewicz Lech , Reil Gert-Hinrich , Ensminger Stephan , Scharfschwerdt Michael , Aboud Anas 
Published: September 2023

IntroductionDrug therapy to reduce the regurgitation fraction (RF) of high-grade aortic regurgitation (AR) by increasing heart rate (HR) is generally recommended. However, chronic HR reduction in HFREF patients can significantly improve aortic compliance and thereby potentially decrease RF. To clarify these contrasts, we examined the influence of HR, aortic compliance and stroke volume (SV) on RF in an ex vivo porcine model of severe AR.MethodsExperiments were performed on porcine ascending aorta with aortic valves (n=12). Compliance was varied by inserting a Dacron graft close to the aortic valve. Both tube systems were connected to a left heart simulator varying HR and SV. AR was accomplished by punching a 0.3 cm2hole in one aortic cusp. Flow, RF, SV and aortic pressure were measured, aortic compliance with transoesophageal ultrasound probes.ResultsCompliance of the aorta was significantly reduced after Dacron graft insertion (0.55%±0.21%/mm Hg vs 0.01%±0.007%/mm Hg, p<0.001, respectively). With increasing HR, RF was significantly reduced in each steady state of the native aorta (HR 40 bpm: 88%±7% vs HR 120 bpm: 42%±10%; p<0.001), but Dacron tube did not affect RF (HR 40 bpm: 87%±8%; p=0.79; HR 120 bpm: 42%±3%; p=0.86). Increasing SV also reduced RF independent of the stiff Dacron graft.ConclusionAortic compliance did not affect AR in the ex vivo porcine model of AR. RF was significantly reduced with increasing HR and SV. These results affirm that HR lowering and negative inotropic drugs should be avoided to treat severe AR.
Shell-model calculations for two-neutron transfer near the $$N=20$$ island of inversion
Authors: Wuosmaa Alan H. , Stecenko Juliette K. 
Published: September 2023

AbstractWe describe connections between shell-model calculation results and predictions for two-nucleon transfer reactions. Measurements of the $$^{30}$$

30

Mg(t,p)$$^{32}$$

32

Mg reaction were used to identify a low-lying shape-coexisting 0$$^+$$

+

state in $$^{32}$$

32

Mg. Interpretations of those early, limited data were based on simple empirical models. The cross sections for two-nucleon transfer are, however, extremely sensitive to the details of the nuclear-structure. Motivated by the possibility of new high-resolution two-nucleon transfer measurements around the $$N=20$$

N
=
20

Island of Inversion, we have performed shell-model calculations wave functions for states in the nuclei $$^{30,32}$$

30
,
32

Mg using the SDPF-M and SDPF-MU interactions, and from those calculations obtain the two-nucleon transfer amplitudes that we use to predict cross sections for the $$^{28,30}$$

28
,
30

Mg(t,p)$$^{30,32}$$

30
,
32

Mg reactions. The combined results show how the nuclear structure properties influence experimental observables for the (t,p) reaction. We compare our results with the existing data.
Coherent structure modification by a shear acting at the surface of a turbulent open channel
Authors: Chibbaro Sergio , Reyes Jair , Rossi Maurice , Soldati Alfredo , Zonta Francesco 
Published: September 2023

AbstractRecent experiments in the river Seine have revealed the presence of persistent large rolls. This finding has motivated the present numerical study of a turbulent open channel flow. Our pseudo-spectral direct numerical simulations are aimed at understanding how the shear at the surface, for instance produced by an external wind, can change vortical structures in the bulk. Simulations are run at a Reynolds number in the range $$[5\times 10^3\div 10^4]$$

[
5
×

10
3

÷

10
4

]

, in line with similar laboratory experiments. We investigate how flow structures located near the bottom wall, near the surface or inside the bulk are modified by a surface shear. Statistical signatures are extracted through Fourier analysis of the simulated fields, and typical wavelengths of vortices or streaks are computed. Moreover, instantaneous fields are used to show the existence of upwelling and downwelling motions. These motions can be hindered by the presence of a large enough surface shear. This condition turns out to be necessary for the existence of streaks at the surface as well. Our investigation clarifies the dynamics of vortices in an open channel flow at moderate Reynolds number, indicating that unsteady vortex structures are indeed present, but the existence of long coherent rolls cannot be accounted for by the sole presence of shear at the surface. Numerical studies with a much longer domain and possibly at higher Reynolds numbers are needed to provide a firm answer to the question.
Oncogenic KRASG12D Reprograms Lipid Metabolism by Upregulating SLC25A1 to Drive Pancreatic Tumorigenesis
Authors: Zhang Ruowen , Peng Xiaogang , Du James Xianxing , Boohaker Rebecca , Estevao Igor L. , Grajeda Brian I. , Cox Marc B. , Almeida Igor C. , Lu Weiqin 
Published: September 2023

Abstract

Pancreatic cancer is a highly lethal disease with obesity as one of the risk factors. Oncogenic KRAS mutations are prevalent in pancreatic cancer and can rewire lipid metabolism by altering fatty acid (FA) uptake, FA oxidation (FAO), and lipogenesis. Identification of the underlying mechanisms could lead to improved therapeutic strategies for treating KRAS-mutant pancreatic cancer. Here, we observed that KRASG12D upregulated the expression of SLC25A1, a citrate transporter that is a key metabolic switch to mediate FAO, fatty acid synthesis, glycolysis, and gluconeogenesis. In genetically engineered mouse models and human pancreatic cancer cells, KRASG12D induced SLC25A1 upregulation via GLI1, which directly stimulated SLC25A1 transcription by binding its promoter. The enhanced expression of SLC25A1 increased levels of cytosolic citrate, FAs, and key enzymes in lipid metabolism. In addition, a high-fat diet (HFD) further stimulated the KRASG12D-GLI1-SLC25A1 axis and the associated increase in citrate and FAs. Pharmacologic inhibition of SLC25A1 and upstream GLI1 significantly suppressed pancreatic tumorigenesis in KrasG12D/+ mice on a HFD. These results reveal a KRASG12D-GLI1-SLC25A1 regulatory axis, with SLC25A1 as an important node that regulates lipid metabolism during pancreatic tumorigenesis, thus indicating an intervention strategy for oncogenic KRAS-driven pancreatic cancer.

Significance:
Upregulation of SLC25A1 induced by KRASG12D-GLI1 signaling rewires lipid metabolism and is exacerbated by HFD to drive the development of pancreatic cancer, representing a targetable metabolic axis to suppress pancreatic tumorigenesis.
slan+ Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis
Authors: Finotti Giulia , Pietronigro Enrica , Balanzin Camillo , Lonardi Silvia , Constantin Gabriela , Chao Mark P. , Tecchio Cristina , Vermi William , Cassatella Marco A. 
Published: September 2023

Abstract
Monocytes positive for 6-Sulfo LacNAc (slan) are a major subset of nonclassical CD14dimCD16+ monocytes in humans. We have shown that slan+ cells infiltrate lymphomas and elicit an antibody-dependent cellular cytotoxicity (ADCC) of neoplastic B cells mediated by the anti-CD20 therapeutic rituximab. Herein, by performing blocking experiments and flow cytometry analyses, as well as confocal microscopy and live-cell imaging assays, we extended the findings to other humanized antibodies and deciphered the underlying effector mechanism(s). Specifically, we show that, after coculture with target cells coated with anti-CD20 or anti-CD38, slan+ monocytes mediate trogocytosis, a cell–cell contact dependent, antibody-mediated process that triggers an active, mechanic disruption of target cell membranes. Trogocytosis by slan+ monocytes leads to a necrotic type of target cell death known as trogoptosis, which, once initiated, was partially sustained by endogenous TNFα. We also found that slan+ monocytes, unlike natural killer (NK) cells, mediate a direct ADCC with all types of anti-CD47 analyzed, and this was independent of their IgG isotype. The latter findings unveil a potentially relevant contribution by slan+ monocytes in mediating the therapeutic efficacy of anti-CD47 in clinical practice, which could be particularly important when NK cells are exhausted or deficient in number. Overall, our observations shed new light on the cytotoxic mechanisms exerted by slan+ monocytes in antibody-dependent tumor cell targeting and advance our knowledge on how to expand our therapeutic arsenal for cancer therapy.
Prognosis of Systolic Pressure 130 to 139 According to Risk. A Prospective Cohort Study Between 1992 and 2019
Authors: Divison-Garrote Juan A. , Carbayo-Herencia Julio A. , Simarro-Rueda Marta , Molina-Escribano Francisca , Escobar-Cervantes Carlos , Artigao-Rodenas Luis M. , Gil-Guillén Vicente , Banegas José R. 
Published: September 2023

BACKGROUND:
Guidelines recommend pharmacological treatment for systolic blood pressure (SBP) of 130 to 139 mm Hg in secondary prevention. However, uncertainty persists in primary prevention in low cardiovascular risk patients (CVR).

METHODS:
Cohort study representative of the general population of Albacete/Southeast Spain. We examined 1029 participants with untreated blood pressure and free of cardiovascular disease, followed-up during 1992 to 2019. Cox regression modeled the association of SBP with cardiovascular morbidity and mortality (outcome-1) and cardiovascular morbidity and all-cause mortality (outcome-2).

RESULTS:

Participants’ mean age was 44.8 years (53.8%, women; 77.1% at low-CVR); 20.3% had SBP 120 to 129; 13.0% 130 to 139 at low-CVR and 3.4% at high-CVR; and 27.4% ≥140 mm Hg. After a 25.7-year median follow-up, 218 outcome-1 and 302 outcome-2 cases occurred. Unadjusted hazard ratios of outcome-1 for these increasing SBP categories (versus <120) were 2.72, 2.27, 11.54, and 7.52, respectively; and 2.69, 2.32, 10.55, and 7.34 for outcome-2 (all
P
<0.01). After adjustment for other risk factors, hazard ratio (95% CI) of outcome-1 were 1.49 (0.91–2.44), 1.65 (0.94–2.91,
P
=0.08), 1.36 (0.72–2.57), and 1.82 (1.15–2.88), respectively, and 1.39 (0.91–2.11), 1.69 (1.05–2.73), 1.09 (0.63–1.88), and 1.64 (1.11–2.41) for outcome-2. Compared with 130 to 139 at low-CVR, hazard ratio for 130 to 139 at high-CVR was 4.85 for outcome-1 (
P
<0.001) and 4.43 for outcome-2 (
P
<0.001).

CONCLUSIONS:
In this primary prevention population of relatively young average age, untreated SBP of 130 to 139 mm Hg at low-CVR had long-term prognostic value and might benefit from stricter SBP targets. High-CVR patients had nonsignificant higher risk (limited sample size) but 4-fold greater risk when compared with low-CVR. Overall, results indicate the importance of risk stratification, supporting risk-based decision-making.
Tracing data: A survey investigating disciplinary differences in data
citation
Authors: Gregory Kathleen , Ninkov Anton , Ripp Chantal , Roblin Emma , Peters Isabella , Haustein Stefanie 
Published: September 2023

Abstract
Data citations, or citations in reference lists to data, are increasingly seen as an important means to trace data reuse and incentivize data sharing. Although disciplinary differences in data citation practices have been well documented via scientometric approaches, we do not yet know how representative these practices are within disciplines. Nor do we yet have insight into researchers’ motivations for citing—or not citing—data in their academic work. Here, we present the results of the largest known survey (n = 2,492) to explicitly investigate data citation practices, preferences, and motivations, using a representative sample of academic authors by discipline, as represented in the Web of Science (WoS). We present findings about researchers’ current practices and motivations for reusing and citing data and also examine their preferences for how they would like their own data to be cited. We conclude by discussing disciplinary patterns in two broad clusters, focusing on patterns in the social sciences and humanities, and consider the implications of our results for tracing and rewarding data sharing and reuse.
Improved Seasonal Forecast Skill of Pan-Arctic and Regional Sea Ice Extent in CanSIPS Version 2
Authors: Martin Joseph , Monahan Adam , Sigmond Michael 
Published: September 2023

Abstract
This study assesses the forecast skill of the Canadian Seasonal to Interannual Prediction System (CanSIPS), version 2, in predicting Arctic sea ice extent on both the pan-Arctic and regional scales. In addition, the forecast skill is compared to that of CanSIPS, version 1. Overall, there is a net increase of forecast skill when considering detrended data due to the changes made in the development of CanSIPSv2. The most notable improvements are for forecasts of late summer and autumn target months that have been initialized in the months of April and May that, in previous studies, have been associated with the spring predictability barrier. By comparison of the skills of CanSIPSv1 and CanSIPSv2 to that of an intermediate version of CanSIPS, CanSIPSv1b, we can attribute skill differences between CanSIPSv1 and CanSIPSv2 to two main sources. First, an improved initialization procedure for sea ice initial conditions markedly improves forecast skill on the pan-Arctic scale as well as regionally in the central Arctic, Laptev Sea, Sea of Okhotsk, and Barents Sea. This conclusion is further supported by analysis of the predictive skill of the sea ice volume initialization field. Second, the change in model combination from CanSIPSv1 to CanSIPSv2 (exchanging the constituent CanCM3 model for GEM-NEMO) improves forecast skill in the Bering, Kara, Chukchi, Beaufort, East Siberian, Barents, and the Greenland–Iceland–Norwegian (GIN) Seas. In Hudson and Baffin Bay, as well as the Labrador Sea, there is limited and unsystematic improvement in forecasts of CanSIPSv2 as compared to CanSIPSv1.
Can inflammatory indexes predict the spontaneous passage of common bile duct stones?
Authors: Küçük İrfan , Yazgan Yusuf , Tural Ersin , Yıldırım İdris , Akbaş Şimşek Tuğba , Çakır Güney Başak , Kaplan Mustafa 
Published: September 2023

Objectives We aimed to determine whether inflammatory indexes (II), including the neutrophil–lymphocyte ratio (NLR), the C-reactive protein (CRP) to albumin ratio (CAR), the CRP–lymphocyte ratio (CLR), and the systemic immune-inflammation index (SIII) can be diagnostic for common bile duct stones (CBDSs) excretion before endoscopic retrograde cholangiopancreatography (ERCP). Backgrounds Because of the spontaneous clearance, it is mandatory to ascertain the presence of CBDSs before ERCP. Methods Retrospectively, we evaluated two groups. Group A included 96 records in which CBDSs existed in magnetic resonance cholangiopancreatography (MRCP) and ERCP. Group B included 36 records in which CBDSs existed in MRCP but not ERCP. IIs were calculated on presentation and before ERCP. Results Stone detection in ERCP had a 3.992-fold (95% 1.769–9.007) higher probability with a stone larger than 3.25 mm in MRCP. Before ERCP, CAR, and CLR values were higher in group A than in group B (3.88 [1.25–14.14] and 1.24 [0.50–9.66], p  = 0.027 versus 8.79 [2.19–35] and 2.67 [1.02–20.05], p  = 0.029 , respectively). Higher CRP, CAR, and CLR values were considered significant for detecting a stone in ERCP (AUC: 0.627 [0.519–0.739], 0.625 [0.513–0.737], and 0.624 [0.514–0.734], respectively). Conclusion Low CRP, CAR, and CLR values might associate with the spontaneous migration of CBDS.
Impact of sarcopenia on long-term survival after cardiac surgery for end-stage renal disease patients
Authors: Ikushima Eigo , Yasutsune Toru , Kishigami Takehiro , Takigawa Tomoya , Jinzai Yuki , Kado Yuichiro , Nishimura Yosuke 
Published: September 2023

Background The long-term mortality of end-stage renal disease (ESRD) patients is still unsatisfactory. Therefore, long-term risk assessments in ESRD patients undergoing cardiac surgery are needed. Recently, sarcopenia is major concern in cardiac surgery because of its association with poor long-term survival. However, the impact of sarcopenia on the long-term survival of ESRD patients undergoing cardiac surgery is not well understood. Methods Eighty-two ESRD patients who underwent elective cardiac surgery were enrolled. Sarcopenia was identified based on noncontrast abdominal computed tomography. The impact of preoperative and intraoperative factors on long-term survival was investigated. Results Forty-three patients (52%) were diagnosed with sarcopenia. The in-hospital mortality rate was 4.9%. The 5-year overall survival rate was 48%. The multivariate analyses revealed that STS score ≥ 4 (odds ratio, 6.0; confidence interval, 2.5–14.7; p < 0.01) and presence of sarcopenia (odds ratio, 2.4; confidence interval, 1.3–4.5; p  =  0.03) were independent risk factors for overall survival. The 5-year survival rates of low-risk (Society of Thoracic Surgeons score of < 4) patients without sarcopenia, low-risk with sarcopenia, more than intermediate-risk (Society of Thoracic Surgeons score of ≥ 4) without sarcopenia, and more than intermediate-risk with sarcopenia groups were 80%, 51%, 50%, and 26%, respectively. Conclusions Among the ESRD patients, the low risk without sarcopenia group showed an excellent long-term survival, in contrast to more than intermediate-risk patients with sarcopenia, who can expect poor long-term survival. Preoperative assessment of sarcopenia in addition to the surgical risk score can be useful in developing a therapeutic strategy.
Cytokine status and significant increase of IL-6 and sIL-6R in the aqueous humor of diabetic cataract patients revealed by quantitative multiplexed assays
Authors: Chen Yan , Hao Wenpei , Wang Mei , Wu Feizhen , Long Da , Li Tingting , Zhang Ye , Wang Xiangning , Lu Bin , Du Changsheng , Wu Qiang 
Published: September 2023

Objective This study aimed to investigate inflammatory cytokine expression profiles in the aqueous humor (AH) of diabetic cataract (DC) patients. Methods A quantitative multiplexed antibody assay was performed to measure the expression levels of 40 inflammatory cytokines in AH samples from DC and age-related cataract (ARC) patients. Bioinformatics analysis was used to examine the functions of the cytokines. Enzyme-linked immunosorbent assays (ELISAs) and western blots were performed to verify the data. Results The multiplexed antibody assay revealed that the expression levels of IL-6, sIL-6R, IL-17A, IL-8, MCP-1, TNF-β, RANTES, TIMP-1, and TIMP-2 were higher in the AH of DC patients compared with ARC patients. However, IL-1ra and IL-1a expression levels were lower in the DC patient AH samples. Pathway analysis indicated that IL-6 and sIL-6R belong to the class I helical cytokine family, which is associated with many biological functions. ELISA and western blot results confirmed that IL-6R and IL-6 expression levels were significantly higher in DC patients compared with ARC patients. Conclusions Our results revealed the status of 40 inflammatory cytokines in the AH by quantitative multiplexed assays. Additionally, IL-6 and sIL-6R were expressed markedly higher in DC compared with ARC, which may play critical roles in DC pathophysiology.
Investigation on mechanical properties of polyamide 6 and carbon fiber reinforced composite manufactured by fused deposition modeling technique
Authors: Shashikumar S , Sreekanth M S 
Published: September 2023

Fused deposition modeling (FDM) is one of the additive manufacturing (AM) techniques in which intricate shapes are produced effectively with time and cost. Thermoplastics and filler-incorporated thermoplastics composite materials were used in the form of filament. The mechanical properties of the printed sample varies with the parameters involved in FDM printing. In the present investigation, polyamide 6 (PA) with 20 wt.% of short carbon fiber (CF) was used as filament. The filaments were printed with different raster orientations namely 0°, 45°, 90°, and ±45° by keeping other printing parameters constant such as 100% infill density, 0.2 mm layer thickness, 30 mm/min printing speed, 240°C printing temperature, 80°C bed temperature, and XY or 0° body orientation with a clear justification studied. The printed samples were investigated for structure, morphology and mechanical properties using tensile test and impact test respectively. The results shows that bidirectional ±45° raster orientation specimens show the highest tensile strength of 35.2 MPa in comparison with 0°,45°, and 90° raster orientation, and PACF composite material showed improved mechanical properties as compared to pure PA. The highest impact energy was observed for a PACF composite with a raster orientation of 90°. Morphological analysis of composites showed a uniform dispersion of CF in PA matrix and improved interfacial adhesion between matrix and reinforcement.
Sunflower oil-based polyurethane/graphene composite: Synthesis and properties
Authors: Suthar Vishwa , Asare Magdalene A , Sahu Pranabesh , Gupta Ram K 
Published: September 2023

Polyurethane/graphene composites have attracted significant attention featuring their wide applications in automotive interiors, coatings, and leather parts to bioengineering. This research focuses on the facile synthesis of biobased polyurethane (PU) by employing sunflower oil as a renewable resource. The synthesized biobased PU was reinforced with graphene nanoplatelets (GNP) and graphene nanoribbons (GNR) to fabricate composite films by solution-casting technique. By changing the filler content (0.01-0.05 wt%), a series of composite films were prepared. The addition of graphene derivatives to the PU matrix improved the mechanical, thermal, and surface properties of the composites compared to the pristine PU film. The incorporation of GNR and GNP fillers enhanced the storage modulus of polymeric film, as for neat PU, was noted maximum at 892 MPa which increased and noticed a maximum of 1121 MPa and 1487 MPa for 0.02 wt % GNP/PU and GNR/PU composite films, respectively. The tensile strength was obtained at 35 MPa and 14 MPa for 0.02 wt % GNP/PU and 0.01 wt % GNR/PU, as compared to 9.45 MPa for the pure PU film. The morphological studies by atomic force microscopy showed a good distribution of GNR and GNP fillers within the polyurethane matrix. The GNP/PU and GNR/PU composite films displayed excellent chemical resistance to different solvents. This work put forward a great utilization of renewable sunflower oil and graphene derivatives to fabricate PU composites with improved properties for potential applications.