bluuebunny/crossref_metadata_2025_split huggingface dataset:
An organic electrochemical transistor for multi-modal sensing, memory and processing
Authors: Wang Shijie , Chen Xi , Zhao Chao , Kong Yuxin , Lin Baojun , Wu Yongyi , Bi Zhaozhao , Xuan Ziyi , Li Tao , Li Yuxiang , Zhang Wei , Ma En , Wang Zhongrui , Ma Wei 
Published: April 2023

AbstractBy integrating sensing, memory and processing functionalities, biological nervous systems are energy and area efficient. Emulating such capabilities in artificial systems is, however, challenging and is limited by the device heterogeneity of sensing and processing cores. Here we report an organic electrochemical transistor capable of sensing, memory and processing. The device has a vertical traverse architecture and a crystalline–amorphous channel that can be selectively doped by ions to enable two reconfigurable modes: a volatile receptor and a non-volatile synapse. As a volatile receptor, the device is capable of multi-modal sensing and is responsive to stimuli such as ions and light. As a non-volatile synapse, it is capable of 10-bit analogue states, low switching stochasticity and good state retention. We also show that the homogeneous integration of the devices could provide functions such as conditioned reflexes and could be used for real-time cardiac disease diagnoses via reservoir computing.
Poisonous Tales
Authors: Hamnett Hilary 
Published: April 2023

Dangerous, dark and difficult to detect, poisons have been a common character in literature from ancient times to the modern day. Their ability to perform deadly deeds at a distance is a common device for creating dramatic tension and playing on our real life fears. But what is fact and what is pure fiction?
From Shakespeare and Dickens to Hugo and Poe, the macabre world of literary poisonings is as large as it is fascinating. Utilising real forensic science Poisonous Tales explores the real science inspiring the toxins and tinctures in our favourite works. Could a poison really mimic death in Romeo and Juliet? What is the cause of the mad Hatter’s malady in Alice in Wonderland? And could a stone from the stomach of a goat really have been used as an antidote in Harry Potter and the Half-Blood Prince? Through these and many more ‘cases’ we discover the captivating truth in the texts and how real-life tragedies can replicate themselves in fiction.
Streamlining Free Radical Green Chemistry
Authors: Perchyonok Tamara , Lykakis Ioannis N. , Postigo Al 
Published: April 2023

The environmental and health hazards created by industrial chemicals and consumer products must be minimized. For safer products to be designed, the relationships between structure and toxicity must be understood at the molecular level. Green chemistry combined with free radical research has the potential to offer innovative solutions to such problems.
Some solutions are "greener then others", and many necessitate significant financial investment. New technology will only be adopted if real benefit can be shown and sometimes adaptation of existing methods is the best option. The efficiency of processes must be assessed, not only in terms of the final yield, but also cost, environmental impact and waste toxicity.
This practical and concise guide showcases the sustainable methods offered by green free radical chemistry and summarizes the fundamental science involved. It discusses the pros and cons of free radical chemistry in aqueous systems for synthetic applications. All transformation steps are covered including initiation, propagation, and termination. Useful background knowledge is combined with examples, including industrial scale processes for pharmaceuticals and fine chemicals.
The book helps chemists to choose appropriate methods for achieving maximum output using a modern, environmentally conscious approach. It shows that, armed with an elementary knowledge of kinetics, an understanding of the mechanistic and technical aspects, and some common sense, it is possible to harness free radicals for use in a broad range of applications.
Streamlining Green Free Radical Chemistry is aimed at chemists, engineers, materials scientists, biochemists and biomedical experts, as well as undergraduate and postgraduate students. It encourages readers to question conventional methods and move towards the "Benign-by-Design" approach of the future. References to further reading are provided at the end of each chapter.
Coherent interference suppression method with virtual array and multi‐stage spatial smoothing
Authors: Zhang Xingyu , Yang Xiaopeng , Qu Xiaodong , Han Bowen , Li Wolin , Zhang Zhengyan 
Published: April 2023

AbstractIn the presence of coherent interference, adaptive beamforming algorithm fails to form nulls in the direction of interference, leading to cancellation of expect signal. To address this issue, this paper proposes a coherent interference suppression method with virtual array and multi‐stage spatial smoothing (MSS). In the proposed method, the adaptive weight acquired by the spatial smoothing (SS) algorithm is applied to all subarrays to generate a virtual array. Another adaptive weight is then acquired from the virtual array using the SS algorithm and applied to all subarrays of the virtual array to generate another virtual array. The process is iterated until there are insufficient array elements for SS. The proposed method can deeply break the correlation between expect signal and coherent interference and form deep nulls in the direction of coherent interference.
A low‐power NPN‐based band‐gap voltage reference in an ultra‐wide temperature range
Authors: Xue Weidong , Zhang Yiseng , Fang Jian , Ren Junyan 
Published: April 2023

AbstractA low‐power negative‐positive‐negative (NPN)‐based bandgap voltage reference (BGR) over an ultra‐wide temperature range is presented. The conventional NPN‐based BGRs cannot maintain a low‐temperature coefficient (TC) with low power consumption in an ultra‐wide temperature range due to its inherent reverse junction saturation current of NPN bipolar junction transistors (BJT) in the high‐temperature range. This work introduces a new NPN‐based BGR unaffected by such saturation current. Based on Vanguard International Semiconductor Corporation (VIS) 0.18 μm/0.15 μm complementary metal oxide semiconductor (CMOS) Bipolar‐CMOS‐DMOS (BCD) process, the BGR receives the best 1.25‐mV deviation over the temperature range of −40°C to 150°C, much less than 38.5 mV from Brokaw‐type BGR. Meanwhile, the proposed BGR with the stacked NPNs for higher output voltage was fabricated. It consumes about 2 uA from a 5‐V power supply, and its average temperature coefficient is 14.89 ppm/°C. Also, the average line sensitivity is 0.039%/V.
Fast and precise underwater transducer characterisation utilising adaptive system identification
Authors: Kaulen Bastian , Schmidt Gerhard 
Published: April 2023

AbstractCharacterising underwater acoustic transducers is essential to optimal signal processing in sound navigation and ranging systems. Precise characterisation allows for equalisation of the input and output hardware, resulting in improved performance of the overall system. A critical quantity of the characterisation is the impulse response of the underwater transducers, which are usually measured in a special low‐noise water tank. An established method in other fields to estimate impulse responses of unknown systems is using adaptive filters and include an inherent quality measure. Such approaches allow for very fast and very reliable measurements. However, when using fixed control parameters, a trade‐off between convergence speed and final mismatch needs to be found, which can be eliminated using variable control parameters. In this article, a method for determining an optimal step size for adaptive algorithms based on the normalised least mean square method is derived based on a theoretical analysis of the convergence process by taking the reverberation parameters of such measurement tanks into account. The new method is specialised on the application of underwater transducer characterisation and allows a very reliable approximation of the optimal step size and thus a maximally fast adaption behaviour—leading to a very short measurement time. This is firstly shown in simulations and afterwards demonstrated in a real measurement with unknown transducers in a measurement water tank.
Reducing Therapeutic Duplication in Inpatient Medication Orders
Authors: E. Dawson Thomas , Beus Jonathan , W. Orenstein Evan , Umontuen Uwem , McNeill Denice , Kandaswamy Swaminathan 
Published: April 2023

Abstract
Background Therapeutic duplication, the presence of multiple agents prescribed for the same indication without clarification for when each should be used, can contribute to serious medical errors. Joint Commission standards require that orders contain clarifying information about when each order should be given. In our system, as needed (PRN) acetaminophen and ibuprofen orders are major contributors to therapeutic duplication.
Objective The objective of this study is to design and evaluate effectiveness of clinical decision support (CDS) to reduce therapeutic duplication with acetaminophen and ibuprofen orders.
Methods This study was done in a pediatric health system with three freestanding hospitals. We iteratively designed and implemented two CDS strategies aimed at reducing the therapeutic duplication with these agents: (1) interruptive alert prompting clinicians for clarifying PRN comments at order entry and (2) addition of discrete “first-line” and “second-line” PRN reasons to orders. Therapeutic duplications were measured by manual review of orders for 30-day periods before and after each intervention and 6 months later.
Results Therapeutic duplications decreased from 1,485 in the 30 days prior to the first alert implementation to 818 in the 30 days after but rose back to 1,208 in the 30 days prior to the second intervention. After discrete reasons were added to the order, therapeutic duplication decreased to 336 in the immediate 30 days and 6 months later remained at 277. Alerts firing rates decreased from 76.0 per 1,000 PRN acetaminophen or ibuprofen orders to 42.9 after the second intervention.
Conclusion Interruptive alerts may reduce therapeutic duplication but are associated with high rates of user frustration and alert fatigue. Leveraging discrete PRN reasons for “first line” and “second line” produced a greater reduction in therapeutic duplication as well as fewer interruptive alerts and less manual entry for providers.
Clinical Outcome in Patients with Large Sinonasal Tumors with Intracranial Extension
Authors: Keizer Max E. , Hovinga Koos E. , Lacko Martin , Eekers Danielle B.P. , Baijens Laura W.J. , Kremer Bernd , Temel Yasin 
Published: April 2023

Abstract
Objectives Malignant tumors of the sinonasal cavities with extension to the frontal skull base are rare and challenging pathologies. Combined-approach surgery using a frontobasal craniotomy and endoscopic sinus surgery with reconstruction of the anterior skull base followed by adjuvant radiotherapy is a preferred treatment strategy in selected cases. Morbidity and mortality rates are high in this population. We aim to add our experience to the current literature.
Design We performed a retrospective cross-sectional single center study of the long-term clinical outcome in a tertiary university referral hospital in the Netherlands between 2010 and 2021. Descriptive statistics and frequency distributions were performed
Participants Patient, tumor, treatment, complications and survival characteristics of eighteen consecutive patients were extracted from the electronic health records.
Main Outcome Measures The primary outcome measures are progression free survival, overall survival and complication rate.
Results Eighteen consecutive patients were included with a mean age of 61 (SD ± 10) years (range 38-80); ten males and eight females. Gross total resection was achieved in 14 (77%) patients. Eleven (61%) patients underwent local radiotherapy, one (5%) chemotherapy and three (17%) a combination of both. Mean follow-up duration was 49 months (range 3 – 138). Three (17%) patients died in hospital due to post-operative complications. Six (33%) patients died during follow-up due to disease progression. Mean progression-free survival was 47 months (range 0 – 113).
Conclusion In conclusion, the overall survival was 50% for this group of patients with large sinonasal tumors. Progressive disease affects survival rate severely. Surgical complications were seen in five (28%) patients. Radiotherapy is associated with high complication rates. Radiation necrosis was a serious complication in two patients and could be treated with high dose steroids.
Frontotemporal Orbitozygomatic Transcavernous Approach: Stepwise Cadaveric Dissection for a Safe Corridor
Authors: Corecha Santos Romel , Gupta Bhavika , Dabecco Rocco , Santiago Raphael Bastianon , Kaye Brandon , Borghei-Razavi Hamid , Adada Badih 
Published: April 2023

Abstract
Background Advances in skull base surgery have increased the need for a detailed understanding of skull base anatomy and its intrinsic relationship to surrounding structures. This has resulted in an improvement in patient outcomes. The frontotemporal orbitozygomatic (FTOZ) transcavernous approach (TCA) is an excellent option for treating complex lesions involving multiple compartments of the skull base, including the sellar and parasellar, third ventricle, orbit, and petroclival region.
Objective This article aimed to provide a detailed cadaveric dissection accompanying a thorough procedure description, including some tips and pitfalls of this technique.
Methods Microsurgical dissection was performed in four freshly injected cadaver heads at the Cranial Base Neuroanatomy Laboratory, Cleveland Clinic Florida. The FTOZ TCA was performed on both sides of the four specimens. The advantages and disadvantages were discussed based on the anatomic nuances of this approach.
Results The FTOZ TCA represented a wide access to the anterior, middle, and posterior fossa. When combined with an anterior clinoidectomy, it allowed for significant and safe internal carotid artery mobilization. This approach created numerous windows, including opticocarotid, carotid-oculomotor, supratrochlear, infratrochlear, anteromedial, anterolateral, and posteromedial triangles. The only drawback was the length of the dissection and the level of surgical acumen required to perform it.
Conclusion Despite its technical difficulty, the FTOZ TCA should be considered for the surgical management of basilar apex aneurysms and tumors surrounding the cavernous sinus, sellar/parasellar, retrochiasmatic, and petroclival region. Continuous training and dedicated time in the skull base laboratory can help achieve the necessary skills required to perform this approach.
A Review on Maternal Parenting, Child's Growth Stunting, and Oral Health
Authors: Abdulaziz Rasyid , Suryanti Netty , Setiawan Arlette Suzy 
Published: April 2023

AbstractStunting has gained global attention as one of the most critical problems in public health. As the first and dominant figure in a child's life, the mother is responsible for determining the proper parenting behaviors to apply to maintain the child's physical health. Stunting is often associated with early childhood caries (ECC) and molar incisor hypomineralization, which can be manifested into each other through various mechanisms. Therefore, it is crucial to explore how far maternal parenting behaviors affect stunting and oral health. This study aims to determine which maternal parenting behaviors can affect stunting and oral health. A systematic search was used through PubMed and Google Scholar to search for published articles between 2011 and 2021. The articles analyze maternal parenting behaviors with stunting and poor oral health. Final analysis was used on 21 articles containing 18 cross-sectional studies, 2 cohort studies, and 1 randomized controlled trial. The result implied that the high prevalence of stunting and ECC is the combined result of prolonged breastfeeding practices (7 articles), poor complementary feeding practice (6 articles), high consumption of sugar (5 articles), and poor oral hygiene practices (5 articles). Maternal parenting styles in the aspect of fulfilling nutrition and maintaining oral health affect the occurrence of stunting and ECC in children.
Anticandidal Efficacy of Erythrosine with Nano-TiO2 and Blue LED-Mediated Photodynamic Therapy against Candida albicans Biofilms on Acrylic Resin: A Preliminary Study
Authors: Damrongrungruang Teerasak , Puasiri Subin , Vongtavatchai Vichakorn , Saeng-on Chatchai , Petcharapiruch Teeruch , Teerakapong Aroon , Sangpanya Angkhana 
Published: April 2023

Abstract
Objective Incorporating an enhancer such as nano-titanium dioxide into antimicrobial photodynamic therapy can improve treatment outcome.This study aimed to compare the anticandidal efficacy of photodynamic therapy by erythrosine with nano-titanium dioxide (nano-TiO2) stimulated by a blue light emitting diode with three standard dental antifungal agents.
Materials and Methods Candida albicans biofilms on acrylic resin plates were treated for 15 minutes with either nystatin, fluconazole, Polident, 220µM erythrosine + 1% (w/w) nano-TiO2 + 15 J/cm2 blue light photodynamic therapy (Ery PDT), or distilled water. For the Ery PDT group, blue light was applied for 1 minute after incubation. After 1, 3, and 6 hours, the colony forming units in log10 (log10CFU/mL) were compared. The ultrastructure of C. albicans on the acrylic resin plates treated with erythrosine + nano-TiO2 + blue light was examined using transmission electron microscopy at magnification of 30,000x.
Results After 1 hour, nystatin, Polident, and Ery PDT indifferently inhibited C. albicans. At 6 hours, Ery PDT reduced the number of viable C. albicans in biofilms by 0.28log10 CFU/mL, which was equal to the effect of fluconazole and Polident. Transmission electron microscopy demonstrated that Ery PDT altered the C. albicans cell morphology by inducing cell wall/membrane rupture.
Conclusion Photodynamic therapy with erythrosine + nano-TiO2 + blue light at low light power density (15 J/cm2) was as effective at inhibiting C. albicans biofilm on acrylic resin as fluconazole and Polident.
Fertility Does not Quarantine: Coronavirus Disease 2019 Pandemic Impacts on in Vitro Fertilization Clinical Pregnancy Rates
Authors: Vieira Fernanda de Almeida , Neto Ricardo Pasquini , Morila Mariana Cristina Gomes , Curimbaba Jean Borges , Pasquini Daniela Sasso , Felchner Paulo Cesar Zimmermann , Wandresen Gustavo , Pachnicki Jan Pawel Andrade 
Published: April 2023

Abstract
Objective To understand the impact of the coronavirus disease 2019 pandemic on in vitro fertilization (IVF) clinical pregnancy rates and analyze factors that may have influenced their outcome.
Methods This was a retrospective observational study conducted at a tertiary-care Brazilian fertility center. All fresh IVF and embryo warming cycles performed from March 11 to December 31, 2018–2021 were analyzed, and their data were used to calculate fertilization, embryo cleavage, cycle cancellation, embryo transfer (ET), and clinical pregnancy rates. Statistical tests were used to evaluate the alterations found. Logistic regression models were used to explore the association of the categorical variables with the observed clinical pregnancy rates. Data from 2018 and 2019 (prepandemic) and 2020 and 2021 (pandemic) were grouped.
Results A total of 756 cycles were analyzed (n = 360 prepandemic and n = 396 pandemic). The age group of the patients, fertilization rates, and cleavage rates did not have significant differences (p > 0.05). There was a reduction in the percentage of fresh IVF and an increase in embryo warming cycles (p = 0.005) during the pandemic. There was also an increase in fresh cycle cancellations (p < 0.001) and a reduction in ET rates (p < 0.001). The pandemic had a negative impact on clinical pregnancy rates (p < 0.001) especially due to the increase in fresh cycle cancellations (p < 0.001).
Conclusion Embryo warming cycles with subsequent frozen-thawed ET were presented as a viable alternative to continue assisted reproductive treatments against pandemic restrictions on fresh cycles, ensuring clinical pregnancy, albeit at a lower rate than that of the prepandemic period.
Phenotypic Heterogeneity of the Mitochondrial DNA Variant m.13513 G > A
Authors: Finsterer Josef 
Published: April 2023

AbstractThe mitochondrial DNA (mtDNA) variant m.13513G > A is increasingly recognized as a cause of syndromic and nonsyndromic mitochondrial disorders (MIDs). This minireview aims a summarizing and discussing recent and previous findings about the phenotypic heterogeneity of this variant. A systematic literature review using the databases PubMed and Google Scholar by application of specific search terms was performed. As per the end of July 2021, at least 50 patients carrying the mtDNA variant m.13513G > A have been reported. Age ranged between 0 and 63 years, and of these patients, 28 were male and 22 were female. The phenotype was highly variable. The most common phenotypes were Leigh syndrome (LS; n = 25), mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS; n = 11), Leigh-like syndrome (n = 4), MELAS/LS (n = 3), progressive external ophthalmoplegia (n = 3), MELAS/Leber's hereditary optic neuropathy (LHON; n = 1), and LHON (n = 1). More rarely are nonsyndromic phenotypes. Heteroplasmy rates were highly variable ranging from 0 to 86% depending on the investigated tissue. The outcome was reported in only a few cases but was worse in patients with LS compared with those with MELAS. The variant m.13513G > A is responsible for syndromic or nonsyndromic MIDs. Syndromic MIDs in which this variant should be particularly considered include LS, MELAS, and LHON and their overlaps. Patients with suspected MID and maternal inheritance should undergo sequencing of the entire mtDNA not to miss rare mtDNA variants.
The influence of the social networks of fund managers on the herding behavior of SIFs in China
Authors: Wang Liang , Wang Yuanfei , Li Bixiao 
Published: April 2023

AbstractThis paper explores the influence of fund managers’ social networks on the herding behavior of securities investment funds (SIFs) in China. Using the data of Chinese SIFs in recent years as a sample, it adopts the CSAD model to measure SIFs’ herding behavior. Combining indicators such as social network centrality, constraint, and size, it constructs a regression model of the influence of fund managers’ social networks on the herding behavior of SIFs and conducts an empirical study. The heterogeneity of this influence is investigated in four dimensions, degree of herding behavior, gender, diploma, and region. The results show that: (i) The larger the social network size of fund managers, the lower the degree of herding behavior of fund managers, but the effect of the network constraint on the degree of herding behavior is not significant. (ii) When the degree of herding behavior of SIFs is high, the effect of network size on herding behavior is heterogeneous. (iii) The relationship between the social network of male fund managers and the degree of herding behavior is more significant than that of female fund managers, as network size is significant for male fund managers, while the regression results of social network centrality, network constraint, network size, and the degree of herding behavior of female fund managers are all not significant. (iv) The social network of the fund manager with a master’s degree has a significant impact on the herding behavior of SIFs, which is not significant in fund managers with Ph.D.