bluuebunny/crossref_metadata_2025_split huggingface dataset:
CutFEM forward modeling for EEG source analysis
Authors: Erdbrügger Tim , Westhoff Andreas , Höltershinken Malte , Radecke Jan-Ole , Buschermöhle Yvonne , Buyx Alena , Wallois Fabrice , Pursiainen Sampsa , Gross Joachim , Lencer Rebekka , Engwer Christian , Wolters Carsten 
Published: August 2023

IntroductionSource analysis of Electroencephalography (EEG) data requires the computation of the scalp potential induced by current sources in the brain. This so-called EEG forward problem is based on an accurate estimation of the volume conduction effects in the human head, represented by a partial differential equation which can be solved using the finite element method (FEM). FEM offers flexibility when modeling anisotropic tissue conductivities but requires a volumetric discretization, a mesh, of the head domain. Structured hexahedral meshes are easy to create in an automatic fashion, while tetrahedral meshes are better suited to model curved geometries. Tetrahedral meshes, thus, offer better accuracy but are more difficult to create.MethodsWe introduce CutFEM for EEG forward simulations to integrate the strengths of hexahedra and tetrahedra. It belongs to the family of unfitted finite element methods, decoupling mesh and geometry representation. Following a description of the method, we will employ CutFEM in both controlled spherical scenarios and the reconstruction of somatosensory-evoked potentials.ResultsCutFEM outperforms competing FEM approaches with regard to numerical accuracy, memory consumption, and computational speed while being able to mesh arbitrarily touching compartments.DiscussionCutFEM balances numerical accuracy, computational efficiency, and a smooth approximation of complex geometries that has previously not been available in FEM-based EEG forward modeling.
A study protocol for a pilot randomized controlled trial to evaluate the effectiveness of a gene-based nutrition and lifestyle recommendation for weight management among adults: the MyGeneMyDiet® study
Authors: Nacis Jacus S. , Labrador Jason Paolo H. , Ronquillo Diana Glades D. , Rodriguez Marietta P. , Dablo Aurora Maria Francesca D. , Frane Ruby D. , Madrid Marilou L. , Santos Noelle Lyn C. , Carrillo Julianne Janine V. , Fernandez Mikko Glen , Gonzales Gerard Bryan L. 
Published: August 2023

IntroductionManaging nutrition and lifestyle practices, nutrition phenotypes, and the genome forms the foundation of precision nutrition. Precision nutrition focuses on metabolic variability among individuals, and one approach to achieving its goals is to integrate gene-based nutrition and lifestyle recommendations in nutrition practice. However, scientific evidence proving the effectiveness of such recommendations is limited. This study will examine whether providing nutrition and lifestyle recommendations based on individual genotype can lead to better weight loss, along with reduction in body mass index (BMI), waist circumference, and body fat percentage among overweight and obese adults.Methods and analysisA parallel group, single-blind, randomized controlled trial will be conducted. Sixty-two overweight/obese individuals aged 19–59 years old will be recruited. Participants will be randomly allocated to either the intervention (n = 31) or the control arm (n = 31). Participants in the intervention group will receive the MyGeneMyDiet® Recommendation for Weight Management, a gene-based nutrition and lifestyle recommendation that was developed based on existing evidence of the effects of FTO rs9939609 on body weight, BMI, and physical activity; UCP1 rs1800592 on calorie intake; and TCF7L2 rs7903146 on dietary fat intake. Participants in the control group will receive the standard recommendations for weight management. The primary outcomes will be the differences in weight, BMI, waist circumference, and body fat percentage between arms in both the active phase (6 months) and inactive phase (last 6 months) of the trial. Participants in both arms will be evaluated at baseline and in months 3, 6, 9, and 12.DiscussionTo the best of our knowledge, this will be the first gene-based intervention that will adopt a phase of intensive nutrition counseling, followed by a simulation of a free-living state to determine adherence to a gene-based recommendation. This study will contribute to the future implementation of precision nutrition interventions by providing evidence on the effectiveness of a gene-based nutrition and lifestyle recommendation for weight loss.Clinical trial registrationclinicaltrials.gov, identifier [NCT05098899].
In vitro and in silico perspectives on the activation of antioxidant responsive element by citrus-derived flavonoids
Authors: Guan Tianzhu , Bian Canfeng , Ma Zheng 
Published: August 2023

IntroductionOxidative stress plays an essential role in the pathogenesis of chronic diseases. Disrupting the Keap1-Nrf2 pathway by binding Keap1 is identified as a potential strategy to prevent oxidative stress-related chronic diseases. Therefore, of special interest is the utilization of dietary antioxidations from citrus, including narirutin, naringenin, hesperetin, hesperidin, naringin, neohesperidin dihydrochalcone, neohesperidin, and nobiletin, has been exploited as a prospective way to treat or prevent several human pathologies as Keap1-Nrf2 inhibitors for modulation of antioxidant properties.MethodsTo probe into the structural foundation of the molecular identification of citrus-derived antioxidations, we calculated the antioxidant responsive element activation ability of citrus-derived flavonoids after binding with Keap1. Also, the quantum chemistry properties and binding mode were performed theoretically with frontier molecular orbitals, molecular electrostatic potential analysis, molecular docking, and absorption, distribution, metabolism, excretion (ADME) calculation.Results and discussionExperimental findings combining computational assays revealed that the tested citrus-derived flavonoids can be grouped into strong agonists and weak agonists. The citrus-derived antioxidations were well housed in the bound zone of Keap1 via stable hydrogen bonding and hydrophobic interaction. Eventually, three of eight antioxidations were identified after ADME and physicochemical evaluations. The citrus-derived flavonoids were identified as potential dietary antioxidants of the Keap1-Nrf2 interaction, and can be used to improve oxidative stress-related chronic diseases.
Anti-cancer treatment within two weeks serves as a risk factor for clinical outcomes among cancer patients with COVID-19
Authors: Huang Jia-Xin , Liu Bo , Cong Xiao-Feng , Guan Yan-Jie , Zhang Yi-Qun , Song Wei , Li Zhi , Liu Zi-Ling , Wang Nan-Ya 
Published: August 2023

BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has resulted in infections among patients with cancer. Our study aimed to investigate the potential adverse impact of anti-cancer treatments within 2 weeks of COVID-19 infection on clinical outcomes in patients with cancer.MethodsThis retrospective cohort study analyzed 70 cancer patients with COVID-19 infection from the First Hospital of Jilin University in Changchun City, Jilin Province, between March and June 2022. Data on demographic characteristics, vaccination status, COVID-19 clinical classification, symptoms, complications, tumor-related characteristics, laboratory examinations and medical interventions were extracted from electronic medical record. The primary outcome of our study was Intensive Care Unit (ICU) admission. Logistic regression model was performed to investigate the association between anti-cancer treatments within 2 weeks after COVID-19 infection and the risk of ICU admission.ResultsOf the 70 patients enrolled in this study, 37 received anti-cancer treatments within 2 weeks after COVID-19 infection. Patients receiving anti-cancer treatment were more likely to experience non-mild COVID-19, require oxygen therapy, develop acute respiratory distress syndrome (ARDS) and exhibit elevated inflammatory levels. The risk of ICU admission (P&lt;0.001) and 30-day mortality after reverse transcriptase polymerase chain reaction (RT-PCR) negative conversion (P=0.007) was significantly higher in patients receiving anti-cancer treatments. In multivariate Logistic regression analysis, non-mild classification of COVID-19, anti-cancer treatments within 2 weeks and ECOG &gt; 1were all independently associated with ICU admission after adjusting for confounder factors. The risk of ICU admission rose to 43.63 times (95% confidence interval=1.31–1452.94, P=0.035) in patients receiving anti-cancer treatments within 2 weeks.ConclusionAnti-cancer treatments within 2 weeks of COVID-19 infection increase the risk of ICU admission and 30-day mortality after RT-PCR negative conversion in patients with cancer. It may be recommended to postpone cancer-related treatments for more than 2 weeks in cancer patients with COVID-19 infection.
The effects of a group-based intervention through physical activities and dietary changes in young patients with severe psychiatric disorders: a pilot study
Authors: Sentissi Othman , Zosso Gabrielle , Cogordon Anouck , Chillà Chiara 
Published: August 2023

Background and objectivesThe present study aims to investigate the effect of the 4-F (Fit, Fun, Feel, and Food) group-based program on physical, clinical, and biological outcomes in young patients suffering from severe psychiatric disorders.MethodsA pilot study with a naturalistic design was conducted to investigate the effect of a group-based intervention on young patients.ResultsA descriptive analysis revealed that out of the 61 outpatients initially enrolled in the program, with a mean age of 26.9 years old (±6.1, 60% men), 71% were overweight or obese. Paired T-tests for the difference between T0 and T1 were used to evaluate the evolution of the outcomes. The 24 patients who completed the full program showed no significant decrease in weight or body composition. Despite the limitations, the main findings of this study were the significant improvement in muscular endurance and coordination (from T0 (M = 13.65, SD = ±1.93) compared to T1 (M = 12.49, SD = ±1.81), [t(20) = 3.072, p &lt; 0.05] and the general increase in mental well-being from baseline to the end of the program according to the type of psychopathology [F(3,10) = 4.25, p &lt; .05]. A slight modification in eating behavior, with a tendency towards a decrease in TFEQ hunger levels, was also noticed. The ANCOVA showed no difference in outcomes between the groups based on diagnosis.ConclusionDespite its limitations and the small sample size, this pilot study provides valuable insights, demonstrating the feasibility of the program and its positive impact on physical well-being and improved mental health in young patients with psychiatric disorders, sedentary behavior, and unhealthy lifestyles. These encouraging results warrant further research in controlled, larger population samples to deepen our understanding of the potential effects of such interventions.
Case report: Impact of mixed reality on anatomical understanding and surgical planning in a complex fourth ventricular tumor extending to the lamina quadrigemina
Authors: Colombo Elisa , Bektas Delal , Regli Luca , van Doormaal Tristan 
Published: August 2023

Background and importanceTumors of the fourth ventricle account for 1%–5% of all intracranial neoplastic lesions and present with different configurations and anatomical challenges. Microsurgery represents the primary therapeutic strategy for the majority of fourth ventricular tumors, and adequate anatomical understanding and visualization are paramount to surgical planning and success. The authors present the case of a young patient with a complex fourth ventricular tumor, whose surgery was successfully planned using a novel mixed reality (MxR) system.Case descriptionWe present a case of a 31-year-old woman with a lesion extending from the fourth ventricle to the lamina quadrigemina and causing symptomatic hydrocephalus occlusus. Through the combined use of routine 2D images and an interactive 3D anatomical model, an interhemispheric transtentorial approach was used to remove 98% of the lesion with successful functional outcomes.ConclusionsThe application of advanced 3D visualization with a novel MxR system to the surgical planning of a complex fourth ventricular lesion proved relevant in designing the best surgical approach and trajectory to better identify potential intraoperative challenges and rehearse the patient-specific anatomy. The present case report endorses the implementation of advanced 3D visualization in routine perioperative practice.
Social and ethical implications of data and technology use on farms: a qualitative study of Swedish dairy and pig farmers
Authors: Doidge Charlotte , Frössling Jenny , Dórea Fernanda C. , Ordell Anna , Vidal Gema , Kaler Jasmeet 
Published: August 2023

IntroductionLivestock farmers are being increasingly encouraged to adopt digital health technologies on their farms. Digital innovations may have unintended consequences, but there tends to be a pro-innovation bias in previous literature. This has led to a movement towards “responsible innovation,” an approach that questions the social and ethical challenges of research and innovation. This paper explores the social and ethical issues of data and technologies on Swedish dairy and pig farms from a critical perspective.MethodsSix focus groups were conducted with thirteen dairy and thirteen pig farmers. The data were analysed using reflexive thematic analysis and a digital critical health lens, which focuses on concepts of identity and power.Results and discussionThe analysis generated four themes: extending the self, sense of agency, quantifying animals, and managing human labour. The findings suggest that technologies can change and form the identities of farmers, their workers, and animals by increasing the visibility of behaviours and bodies through data collection. Technologies can also facilitate techniques of power such as conforming to norms, hierarchical surveillance, and segregation of populations based on data. There were many contradictions in the way that technology was used on farms which suggests that farmers cannot be dichotomised into those who are opposed to and those that support adoption of technologies. Emotions and morality played an important role in the way animals were managed and technologies were used by farmers. Thus, when developing innovations, we need to consider users’ feelings and attachments towards the technologies. Technologies have different impacts on farmers and farm workers which suggests that we need to ensure that we understand the perspectives of multiple user groups when developing innovations, including those that might be least empowered.
Duration of constant rate infusion with diazepam or propofol for canine cluster seizures and status epilepticus
Authors: Cagnotti Giulia , Ferrini Sara , Di Muro Giorgia , Avilii Eleonora , Favole Alessandra , D’Angelo Antonio 
Published: August 2023

IntroductionConstant rate infusion (CRI) of benzodiazepines or propofol (PPF) is a therapeutic option for cluster seizures (CS) and status epilepticus (SE) in canine patients non-responding to first-line benzodiazepines or non-anesthetics. However, specific indications for optimal duration of CRI are lacking. The aim of this study was to determine the effect of duration of anesthetic CRI on outcome and length of hospital stay in dogs with refractory seizure activity of different etiology.Study designOpen-label non-randomized clinical trial.Materials and methodsSeventy-three client-owned dogs were enrolled. Two groups [experimental (EXP) vs. control (CTRL)] were compared. The EXP group received diazepam (DZP) or PPF CRI for 12 h (±1 h) and the CTRL group received DZP or PPF CRI for 24 h (±1 h) in addition to a standardized emergency treatment protocol identical for both study groups. The historical control group was made up of a population of dogs already reported in a previously published paper by the same authors. Favorable outcome was defined as seizure cessation after CRI, no seizure recurrence, and clinical recovery. Poor outcome was defined as seizure recurrence, death in hospital or no return to acceptable clinical baseline. Univariate statistical analysis was performed.ResultsThe study sample was 73 dogs: 45 (62%) received DZP CRI and 28 (38%) received PPF CRI. The EXP group was 39 dogs (25 DZP CRI and 14 PPF CRI) and the CTRL group 34 dogs (20 DZP CRI and 14 PPF CRI). We found no statistically significant difference in outcomes between the groups. The median length of stay was 56 h (IQR, 40–78) for the ALL EXP group and 58.5 h (IQR, 48–74.5) for the ALL CTRL group (p = 0.8).ConclusionEven though a shorter DZP or PPF CRI duration was not associated with a worse outcome, the study failed to identify a clear superiority of shorter CRI duration on outcome or length of hospital stay in dogs with refractory seizure activity of different etiology.
Role of p-Coumaric Acid and Micronutrients in Sulfur Dioxide Tolerance in Brettanomyces bruxellensis
Authors: Chandra Mahesh , Branco Patrícia , Prista Catarina , Malfeito-Ferreira Manuel 
Published: August 2023

Sulfite is a common preservative in wine, but the spoilage yeast Brettanomyces bruxellensis can produce volatile phenols even with the recommended sulfite dose. The purpose of this study was to examine how wine components, p-coumaric acid (a precursor of volatile phenols), and micronutrients influence culturability, viability, and volatile phenols production by B. bruxellensis under sulfite stress. In red wine, a high sulfite dose (potassium metabisulfite, 100 mg L−1) led to an immediate death phase followed by growth recovery after two weeks. However, 4-ethylphenol (4-EP) was continuously produced by dead or nonculturable cells. Nonetheless, an event of growth recovery could not be observed in the case of the model wine. However, when the model wine was supplemented with minerals and vitamins, both growth recovery and 4-EP production were noticed, suggesting that the minerals and vitamins played an important role in maintaining the viability of cells under the sulfite stress. The yeast could also utilize the p-coumaric acid (p-CA) as an energy source, showing a specific growth rate of 0.0142 h−1 with 1 mM of p-CA in model wine. Furthermore, the sulfite-stressed cells exhibited ATP production by means of proton efflux while utilizing the p-CA. This work highlights the novel finding that the conversion of p-CA into 4-EP provides sufficient energy for the cell to remain metabolically active under the sulfite stress.
Relations entre la croissance économique et les fluctuations cycliques
Authors: Kaldor Nicholas 
Published: August 2023

Relations between economic growth and cyclical fluctuations
Cyclical fluctuations have always been considered inherent to the dynamics of growth. Cf. Schumpeter ; but his theory is more descriptive than analytical. It is possible, however, to build a cyclical model that is static in that it fluctuates about a constant mean. But this model bears no similarity with the real world in which the most striking fact about the trade cycle is that each successive boom and slump is higher than the previous one. A trend or random shocks may be incorporated into our model without fundamentally modifying its cyclical character. A trend may, for instance, be attributed to population growth or rising productivity. Bui from the point of view of the théory of economic growth this is unsatisfactory : the trend itself remains unexplained ; it is merely postulated. Technical progress and population growth are as much the result as the condition of economic growth. The classics saw in capital accumulation and saving the ultimate causes of growth. But they too are really only aspects of it.
In fact it is the length and amplitude of boom periods which seem to shape the secular rate of growth. An economy, in which entrepreneurs are bold and fundamentally sanguine and are frequently tempted by high profits to indulge in «unhealthy» over expansion during the upswing, is most likely to have a high rate of growth. Higher unstable expectations lead to powerful booms which break through the existing economic structure and bear the economy to ever higher levels. Each successive trough will also be higher, thus providing higher starting points for the next upswing. Conversely a timid, prudent entrepreneurial spirit will cause only moderate cycles and hence a slow rale of growth. Thus Schumpeter’s dynamic entrepreneur plays an essential part in both cyclical fluctuations and secular growth.
A note on static models of the cycle follows the article.
Oscillation et croissance
Authors: Guitton Henri 
Published: August 2023

Oscillation and growth.
The world economy exhibits both a trend and oscillations. These phenomena have traditionally been dissociated and studied separately. The trend-oscillation dichotomy has given rise to an exogenous-endogenous dichotomy, a long-term — short-term dichotomy and a strudural-conjundural dichotomy.
The cycle dissociated from its trend is, to use Kaldor's expression, a static cycle. It derives from physics and has given rise to many models with either an implicit oscillator (Aftalion, Hawtrey) or an explicit one (Kaldor, Samuelson, Metzler). All show that a trendless cycle is possible.
The trend without cycles is the older approach : Smith, Ricardo, Malthus considered secular movements fundamental, oscillations negligible. The trend may, first, merely be expressed as an annual rale of growth (Harrod’s growth coefficient) based on observable data. It is, secondly, a phenomenon to be explained : growth is governed by increasing population and productivity, and institutional rigidities.
The 'Kondratieff wave is however a problem case in the trend-oscillation dichotomy : is it due to exogenous (or structural ) causes, or endogenous (or confunclural) ones ? The dissociation of trend and cycle is, in fact, dangerous ; they must be studied jointly. Two approaches are possible. According to the first, growth is a succession of open cycles, i. e. is generated by cyclical forces. According to the second, cycles are a by-product of growth (Harrod's and Domar’s view) ; it is well-known that a change in the rale of growth of one series can change the direction of another : a crisis is thus equated to a change in the rale of growth. (An intermediate case is Hicks's model : cycles are sandwiched between a rising floor and ceiling. But these limits, as Goodwin has shown, remain unexplained).
The first approach (cycles determining growth) is by far the most frequently adopted. The second approach should now be developed. This would entail, in particular, the study of economic structures — a vague term which needs expliciting — the importance of which has been stressed by Akerman.