bluuebunny/crossref_metadata_2025_split huggingface dataset:
Video-mediated dialogue for promoting equity in protected area conservation
Authors: Mistry Jayalaxshmi , Jafferally Deirdre , Mendonca Sean , Xavier Rebecca , Albert Grace , Robertson Bernie , George Ena , Benjamin Ryan , Ingwall-King Lisa 
Published: February 2023

AbstractImproving equity in the context of protected areas conservation cannot be achieved in situations where people have different capabilities to participate. Participatory video has the potential to uncover hidden perspectives and worldviews and to build trustworthy, transparent and accountable relationships between marginalized communities and external agencies. We present findings from video-mediated dialogues between Indigenous peoples and decision makers involved in the management of three protected areas in Guyana. Participatory films created by Indigenous researchers in their communities were screened and discussed with protected area managers. We recorded their responses and presented them back to the communities. We show how the video-mediated process provided a rich and contextualized understanding of equity issues. It enabled recognition and respect by protected area managers for Indigenous lived experiences and the contribution of their values and knowledge. For Indigenous peoples, the participatory video process built confidence and critical reflection on their own activities and responsibilities whilst allowing them to challenge decision makers on issues of transparency, communication and accountability. We show that equity is an evolving process and that different protected areas with their differing histories and relationships with Indigenous communities produce distinct outcomes over time. Thus, promoting equity in protected areas and conservation must be a long-term process, enabling participation and producing the conditions for regular, transparent and honest communications. Standardized indicators of protected areas equity could be useful for reporting on international targets, but video-mediated dialogue can facilitate deeper understanding, greater representation and a recognition of rights.
The parent’s and the child’s internal working models of each other moderate cascades from child difficulty to socialization outcomes: Preliminary evidence for dual moderation?
Authors: Kochanska Grazyna , An Danming 
Published: February 2023

AbstractInfants’ difficulty, typically characterized as proneness to negative emotionality, is commonly considered a risk for future maladaptive developmental trajectories, mostly because it often foreshadows increased parental power assertion, typically linked to future negative child outcomes. However, growing evidence of divergent developmental paths that unfold from infant difficulty has invigorated research on causes of such multifinality. Kochanska et al. (2019) proposed that parent and child Internal Working Models (IWMs) of each other are key, with the parent’s IWM of the child moderating the link between child difficulty and parental power assertion, and the child’s IWM of the parent moderating the link between power assertion and child outcomes. In Children and Parents Study (200 community mothers, fathers, and children), child difficulty was observed at 8 months, parents’ power assertion at 16 months, and children’s outcomes rated by parents at age 3. Parents’ IWMs were assessed with a mentalization measure at 8 months and children’s IWMs were coded from semi-projective narratives at age 3. The cascade from infant difficulty to maternal power assertion to negative child outcomes was present only when both the mother’s and the child’s IWMs of each other were negative. We did not support the model for father-child dyads.
Prediction of the Risk of Sepsis by Using Analysis of Plasma Glucose and Serum Lactate in Ambulance Services: A Prospective Study
Authors: Olander Agnes , Magnusson Carl , Sundler Annelie J. , Bremer Anders , Andersson Henrik , Herlitz Johan , Axelsson Christer , Andersson Hagiwara Magnus 
Published: February 2023

AbstractIntroduction:The early recognition of patients with sepsis is difficult and the initial assessment outside of hospitals is challenging for ambulance clinicians (ACs). Indicators that ACs can use to recognize sepsis early are beneficial for patient outcomes. Research suggests that elevated point-of-care (POC) plasma glucose and serum lactate levels may help to predict sepsis in the ambulance service (AS) setting.Study Objective:The aim of this study was to test the hypothesis that the elevation of POC plasma glucose and serum lactate levels may help to predict Sepsis-3 in the AS.Methods:A prospective observational study was performed in the AS setting of Gothenburg in Sweden from the beginning of March 2018 through the end of September 2019. The criteria for sampling POC plasma glucose and serum lactate levels in the AS setting were high or intermediate risk according to the Rapid Emergency Triage and Treatment System (RETTS), as red, orange, yellow, and green if the respiratory rate was >22 breaths/minutes. Sepsis-3 were identified retrospectively. A primary and secondary analyses were carried out. The primary analysis included patients cared for in the AS and emergency department (ED) and were hospitalized. In the secondary analysis, patients who were only cared for in the AS and ED without being hospitalized were also included. To evaluate the predictive ability of these biomarkers, the area under the curve (AUC), sensitivity, specificity, and predictive values were used.Results:A total of 1,057 patients were included in the primary analysis and 1,841 patients were included in the secondary analysis. In total, 253 patients met the Sepsis-3 criteria (in both analyses). The AUC for POC plasma glucose and serum lactate levels showed low accuracy in predicting Sepsis-3 in both the primary and secondary analyses. Among all hospitalized patients, regardless of Sepsis-3, more than two-thirds had elevated plasma glucose and nearly one-half had elevated serum lactate when measured in the AS.Conclusions:As individual biomarkers, an elevated POC plasma glucose and serum lactate were not associated with an increased likelihood of Sepsis-3 when measured in the AS in this study. However, the high rate of elevation of these biomarkers before arrival in hospital highlights that their role in clinical decision making at this early stage needs further evaluation, including other endpoints than Sepsis-3.
Natiolectal Variation in Dutch Morphosyntax: A Large-Scale, Data-Driven Perspective
Authors: De Troij Robbert , Grondelaers Stefan , Speelman Dirk 
Published: February 2023

AbstractIn this article, we report a large-scale corpus study aimed at tackling the (controversial) question to what extent the European national varieties of Dutch, that is, Belgian and Netherlandic Dutch, exhibit morpho-syntactic differences. Instead of relying on a manual selection of cases of morphosyntactic variation, we first marshal large bilingual parallel corpora and machine translation software to identify semiautomatically, in an extensively data-driven fashion, loci of variation from various “corners” of Dutch grammar. We then gauge the distribution of con-structional alternatives in a nationally as well as stylistically stratified corpus for a representative selection of twenty alternation patterns. We find that natiolectal variation in the grammar of Dutch is far more prevalent than often assumed, especially in less edited text types, and that it shows up in inflection phenomena, lexically conditioned syntactic variation, and pure word order permutations. Another key finding is that many cases of synchronic probabilistic asymmetries reflect a diachronic difference between the two varieties: Netherlandic Dutch often tends to be ahead in cases of ongoing grammatical change, with Belgian Dutch holding on somewhat longer to obsolescent features of the grammar.*
Successfully changing the mode of regulation in clinical priority setting: how organisational factors contributed to establishing the Norwegian priority guidelines for specialist health care services
Authors: Aase-Kvåle Irene 
Published: February 2023

AbstractThis article investigates factors that contributed to the successful introduction of 33 priority guidelines for Norwegian specialist health care from 2008 to 2012. The guidelines constituted an important step in changing the regulation of clinical priority setting from largely self-regulation by medical professionals to a more centralised and hierarchical form, and therefore, resistance from the medical profession was expected. My focus is on organisational factors within the project that developed the guidelines, using policy documents and project documents as the main source of data. I find that the project was characterised by a high level of autonomy in terms of how it was organised and the actors included, with significant capacity for action in terms of both structure and personnel, and a broad inclusion of affected actors. The priority guideline project was dominated by medical professionals, and its organisation did not represent a radical break with established traditions of medical professional self-regulation. Although organisational autonomy, action capacity and broad inclusion were clearly of importance, the project's compliance with historical traditions and norms of medical governance stands out as the key factor in understanding the successful establishment of the priority guidelines.
Wind‐Driven and Seasonal Effects on Marine Aerosol Production in the Bellingshausen Sea, Antarctica
Authors: Dasarathy S. , Russell L. M. , Rodier S. D. , Bowman J. S. 
Published: February 2023

AbstractWe assessed satellite‐retrieved marine aerosol in the western Antarctic Peninsula (WAP) across a 12‐year period from coarse‐mode aerosol optical depth (AODC), often used as a proxy for sea spray aerosol (SSA), and marine aerosol optical depth (MAOD), a newly developed proxy for tropospheric marine aerosol. Across open ocean to coastal regions, daily fluctuations in nighttime and daytime winds, respectively, drove increasing MAOD and AODC. MAOD depicted strong correlations with wind speed across open ocean and weak correlations in coastal regions. In the open ocean, AODC exhibited a very weak significant correlation to wind speed and a weak significant correlation to sea surface temperature (SST). We thus observed that warmer SST enhanced the production of SSA, supporting prior studies. This is the first study to assess patterns of AODC in the WAP. In contrast to the tropical Pacific, seasonal patterns showed that biological activity likely contributed toward MAOD and AODC magnitudes.
Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs
Authors: Diepstraten Sarah T. , Young Savannah , La Marca John E. , Wang Zilu , Kluck Ruth M. , Strasser Andreas , Kelly Gemma L. 
Published: February 2023

AbstractBH3-mimetic drugs are an anti-cancer therapy that can induce apoptosis in malignant cells by directly binding and inhibiting pro-survival proteins of the BCL-2 family. The BH3-mimetic drug venetoclax, which targets BCL-2, has been approved for the treatment of chronic lymphocytic leukaemia and acute myeloid leukaemia by regulatory authorities worldwide. However, while most patients initially respond well, resistance and relapse while on this drug is an emerging and critical issue in the clinic. Though some studies have begun uncovering the factors involved in resistance to BCL-2-targeting BH3-mimetic drugs, little focus has been applied to pre-emptively tackle resistance for the next generation of BH3-mimetic drugs targeting MCL-1, which are now in clinical trials for diverse blood cancers. Therefore, using pre-clinical mouse and human models of aggressive lymphoma, we sought to predict factors likely to contribute to the development of resistance in patients receiving MCL-1-targeting BH3-mimetic drugs. First, we performed multiple whole genome CRISPR/Cas9 KO screens and identified that loss of the pro-apoptotic effector protein BAX, but not its close relative BAK, could confer resistance to MCL-1-targeting BH3-mimetic drugs in both short-term and long-term treatment regimens, even in lymphoma cells lacking the tumour suppressor TRP53. Furthermore, we found that mouse Eµ-Myc lymphoma cells selected for loss of BAX, as well as upregulation of the untargeted pro-survival BCL-2 family proteins BCL-XL and A1, when made naturally resistant to MCL-1 inhibitors by culturing them in increasing doses of drug over time, a situation mimicking the clinical application of these drugs. Finally, we identified therapeutic approaches which could overcome these two methods of resistance: the use of chemotherapeutic drugs or combined BH3-mimetic treatment, respectively. Collectively, these results uncover some key factors likely to cause resistance to MCL-1 inhibition in the clinic and suggest rational therapeutic strategies to overcome resistance that should be investigated further.
MLKL deficiency protects against low-grade, sterile inflammation in aged mice
Authors: Tovey Crutchfield Emma C. , Garnish Sarah E. , Day Jessica , Anderton Holly , Chiou Shene , Hempel Anne , Hall Cathrine , Patel Komal M. , Gangatirkar Pradnya , Martin Katherine R. , Li Wai Suen Connie S. N. , Garnham Alexandra L. , Kueh Andrew J. , Wicks Ian P. , Silke John , Nachbur Ueli , Samson Andre L. , Murphy James M. , Hildebrand Joanne M. 
Published: February 2023

AbstractMLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease. Necroptosis has been implicated in the progression of disease in almost every physiological system and recent reports suggest a role for necroptosis in aging. Here, we present the first comprehensive analysis of age-related histopathological and immunological phenotypes in a cohort of Mlkl–/– and Ripk3–/– mice on a congenic C57BL/6 J genetic background. We show that genetic deletion of Mlkl in female mice interrupts immune system aging, specifically delaying the age-related reduction of circulating lymphocytes. -Seventeen-month-old Mlkl–/– female mice were also protected against age-related chronic sterile inflammation in connective tissue and skeletal muscle relative to wild-type littermate controls, exhibiting a reduced number of immune cell infiltrates in these sites and fewer regenerating myocytes. These observations implicate MLKL in age-related sterile inflammation, suggesting a possible application for long-term anti-necroptotic therapy in humans.
Moonlighting chromatin: when DNA escapes nuclear control
Authors: Singh Jeeshan , Boettcher Michael , Dölling Maximilian , Heuer Annika , Hohberger Bettina , Leppkes Moritz , Naschberger Elisabeth , Schapher Mirco , Schauer Christine , Schoen Janina , Stürzl Michael , Vitkov Ljubomir , Wang Han , Zlatar Leticija , Schett Georg A. , Pisetsky David S. , Liu Ming-Lin , Herrmann Martin , Knopf Jasmin 
Published: February 2023

AbstractExtracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an important element that propels the pathological progression of a plethora of diseases. DNA drives the interferon system, serves as autoantigen, and forms the extracellular scaffold for proteins of the innate immune system. An insufficient clearance of extruded chromatin after the release of DNA from the nucleus into the extracellular milieu can perform a secret task of moonlighting in immune-inflammatory and occlusive disorders. Here, we discuss (I) the cellular events involved in the extracellular release of chromatin and NET formation, (II) the devastating consequence of a dysregulated NET formation, and (III) the imbalance between NET formation and clearance. We include the role of NET formation in the occlusion of vessels and ducts, in lung disease, in autoimmune diseases, in chronic oral disorders, in cancer, in the formation of adhesions, and in traumatic spinal cord injury. To develop effective therapies, it is of utmost importance to target pathways that cause decondensation of chromatin during exaggerated NET formation and aggregation. Alternatively, therapies that support the clearance of extracellular chromatin are conceivable.
Using sub-limb observations to measure gravity waves excited by convection
Authors: Wright Corwin J. , Ungermann Jörn , Preusse Peter , Polichtchouk Inna 
Published: February 2023

AbstractConvective gravity waves are a major driver of atmospheric circulation, including the stratospheric and mesospheric quasi-biennial oscillation (QBO) and the Brewer–Dobson circulation. Previous work shows clear evidence that these waves can be excited by both single convective cells and by mesoscale convective complexes acting as a single unit. However, the partitioning of the generated waves and, crucially for atmospheric model development, the flux of momentum they transport between these two types of excitation process remains highly uncertain due to a fundamental lack of suitable observations at the global scale. Here, we use both theoretical calculations and sampled output from a high-resolution weather model to demonstrate that a satellite instrument using a sub-limb geometry would be well suited to characterising the short-vertical short-horizontal gravity waves these systems produce, and hence to provide the scientific knowledge needed to identify the relative wave-driving contribution of these two types of convective wave excitation.
Severe multi-year drought coincident with Hittite collapse around 1198–1196 bc
Authors: Manning Sturt W. , Kocik Cindy , Lorentzen Brita , Sparks Jed P. 
Published: February 2023

AbstractThe potential of climate change to substantially alter human history is a pressing concern, but the specific effects of different types of climate change remain unknown. This question can be addressed using palaeoclimatic and archaeological data. For instance, a 300-year, low-frequency shift to drier, cooler climate conditions around 1200 bcis frequently associated with the collapse of several ancient civilizations in the Eastern Mediterranean and Near East1–4. However, the precise details of synchronized climate and human-history-scale associations are lacking. The archaeological–historical record contains multiple instances of human societies successfully adapting to low-frequency climate change5–7. It is likely that consecutive multi-year occurrences of rare, unexpected extreme climatic events may push a population beyond adaptation and centuries-old resilience practices5,7–10. Here we examine the collapse of the Hittite Empire around 1200 bc. The Hittites were one of the great powers in the ancient world across five centuries11–14, with an empire centred in a semi-arid region in Anatolia with political and socioeconomic interconnections throughout the ancient Near East and Eastern Mediterranean, which for a long time proved resilient despite facing regular and intersecting sociopolitical, economic and environmental challenges. Examination of ring width and stable isotope records obtained from contemporary juniper trees in central Anatolia provides a high-resolution dryness record. This analysis identifies an unusually severe continuous dry period from around 1198 to 1196 (±3)bc, potentially indicating a tipping point, and signals the type of episode that can overwhelm contemporary risk-buffering practices.
Peak Cenozoic warmth enabled deep-sea sand deposition
Authors: Burton Zachary F. M. , McHargue Tim , Kremer Christopher H. , Bloch Roger B. , Gooley Jared T. , Jaikla Chayawan , Harrington Jake , Graham Stephan A. 
Published: February 2023

AbstractThe early Eocene (~ 56–48 million years ago) was marked by peak Cenozoic warmth and sea levels, high CO2, and largely ice-free conditions. This time has been described as a period of increased continental erosion and silicate weathering. However, these conclusions are based largely on geochemical investigation of marine mudstones and carbonates or study of intermontane Laramide basin settings. Here, we evaluate the marine coarse siliciclastic response to early Paleogene hothouse climatic and oceanographic conditions. We compile an inventory of documented sand-rich (turbidite) deep-marine depositional systems, recording 59 instances of early Eocene turbidite systems along nearly all continental margins despite globally-elevated sea levels. Sand-rich systems were widespread on active margins (42 instances), but also on passive margins (17 instances). Along passive margins, 13 of 17 early Eocene systems are associated with known Eocene-age fluvial systems, consistent with a fluvial clastic response to Paleogene warming. We suggest that deep-marine sedimentary basins preserve clastic records of early Eocene climatic extremes. We also suggest that in addition to control by eustasy and tectonism, climate-driven increases in sediment supply (e.g., drainage integration, global rainfall, denudation) may significantly contribute to the global distribution and volume of coarse-grained deep-marine deposition despite high sea level.
The impact of Brazil’s transport network on the spread of COVID-19
Authors: Silva Giovanna Cavali , Ribeiro Evandro Marcos Saidel 
Published: February 2023

AbstractThe transport network between cities is key in understanding epidemic outbreaks, especially in a vast country like Brazil with 5569 cities spread out over 8.5 million square kilometers. In order to study the COVID-19 spread in Brazil, we built a transport network where each city is a node and the edges are connections by land and air. Our findings have shown that by adding air connections, the average path length substantially decreases (70%) while the clustering coefficient remains almost unchanged, very typical of small-world networks. The airways are shortcuts connecting previously distant cities and hubs, therefore shrinking the distances in the network. Also, the cities with airports are central nodes, which makes them dissemination hotspots and key targets for interventions.
In vivo and in vitro validation of powdery mildew resistance in garden pea genotypes
Authors: Rana Chanchal , Sharma Akhilesh , Rathour Rajeev , Bansuli  , Banyal Devinder Kumar , Rana Ranbir Singh , Sharma Parveen 
Published: February 2023

AbstractPowdery mildew is one of the serious diseases of garden pea which causes a large number of yield losses. Genetic resistance is quite effective, being cost-effective and environment friendly than fungicide applications. In the present studies an initial attempt has been made to identify resistant genotypes against powdery mildew disease developed from hybridization followed by validation of the disease. The experimental material comprised of 48 genotypes that includes 44 advanced breeding lines was evaluated for powdery mildew incidence in Randomized Complete Block Design with three replications at two locations under field conditions [Palampur (winter 2017–18 and 2018–19) and Kukumseri (summer 2018)] and in vitro at Palampur [detached leaf method and polyhouse conditions]. Ten lines viz., SP7, SN-1, SN-6-1, SN-7-1, SN-2, SN-5-2, SN-6-2, SN-10, SN-21 and SP-281 showed resistant reaction along with check Palam Sumool while 27 lines were identified as moderately resistant in comparison to susceptible check Azad P-1. Besides, six lines namely, SP-2, SP-5, SP-10, SP-24, SA-4 and SP-12-1 gave moderately susceptible reaction along with checks Pb-89 and Palam Priya. Only, SP-19 was categorized as susceptible. The high yielding lines SP-3, SP-6 and SP-22 showed moderately resistant reaction in both natural and artificial conditions. Validation of resistance using molecular markers revealed that neither the parental genotypes nor the progenies possess the er1 gene of JI1559. The er2 linked marker ScOPX-171700 was polymorphic between Palam Sumool and Palam Priya but the marker didn’t show polymorphism between er2 harboring line (JI2480). These results suggested that the lines showing resistance under field conditions may have some other genes or alleles for resistance and further confirmation is needed by developing mapping populations with specific gene or gene combinations.