bluuebunny/crossref_metadata_2025_split huggingface dataset:
Which are the vital factors of mobile personal health records applications that promote continued usage? A perspective on technology fit and social capital
Authors: Liu Yao-Yuan , Lu Hsi-Peng , Chen Chiao-Shan 
Published: June 2023

Introduction With the widespread use of mobile devices and the rapid development of mobile networks, connecting mobile personal health record (mPHR) apps to wearable devices to collect personal health data for analysis and community activities has become a trend for health promotion. Therefore, the present study aims to explore the vital factors that impact the sustained usage of mPHR apps. Objective In this study, we identified social lock-in as a major research gap in the current era of social media and the Internet. Therefore, to explore the effects of mPHR apps on continued app usage intention, we combined technology fit (individual-technology, synchronicity-technology, and task-technology fit) and social capital (structural, relational, and cognitive capital) to develop a novel study model. Methods The purpose of this research is to investigate the willingness to participate in the mPHR apps. It collected 565 valid users’ responses through the online questionnaire with a structural equation modeling approach. Results That technology and social lock-in significantly affected the willingness of users to continue using mPHR apps ( β  =  0.38, P < 0.001) and that the effects of social lock-in ( β  =  0.38, P < 0.001) were more pronounced than those of technology lock-in ( β  =  0.22, P < 0.001). Conclusions The technology and social lock-in generated by technology fit and social capital had positive effects on continued app usage and the effects of both types of lock-in on continued app usage varied among different participant groups.
Job Satisfaction and Self-Perceptions Among Ecuadorian Medical Doctors During Their Compulsory Rural Community Social Service: A Countrywide Cross-Sectional Analysis
Authors: Izquierdo-Condoy Juan S. , Morales-Lapo Estefanía , Hidalgo Marlon , Tello-De-la-Torre Andrea , Ruiz-Sosa Carlos , Guerrero-Castillo Galo S. , Sánchez Ordoñez David , Puglla Alexander , Vasconez-Gonzáles Jorge , Carrington Sarah J. , Ortiz-Prado Esteban 
Published: June 2023

Introduction: Job satisfaction has been shown to have important effects at the organizational level. In various corners of the world, physicians are obliged to perform a period of social service, generally at the first level of care in rural or remote areas. Objective: To describe the level of job satisfaction and perceptions of Ecuadorian rural physicians regarding compulsory social service. Methodology: A descriptive, cross-sectional study was conducted based on a self-administered online questionnaire from February to March 2022, in Ecuadorian rural physicians who were performing their compulsory social service. Participants were invited through official outreach groups. A total of 247 surveys were included in this study. We assessed job satisfaction by means of the S20/23 job satisfaction questionnaire and compared these results with sociodemographic variables and job characteristics of the participants. We performed the reliability test (Cronbach’s alpha) to find the validity of the S20/23 questionnaire in physicians performing compulsory social service. Results: The majority of participants were women (61.0%), and overall job satisfaction was 4.1/7.0 pts. “indifferent.” The only satisfaction factor in which a predominance of dissatisfaction was found related to benefits/remuneration (43.3%). Participants’ perceptions of wrong academic guidance during training, insufficient induction, and negative experiences during work were related to higher levels of dissatisfaction ( P < .05). Conclusion: The level of job satisfaction of Ecuadorian rural physicians during their compulsory social service was low and graduates indicated a neutral attitude toward job satisfaction in general. Negative perceptions with respect to training and expectation formation prior to and during the mandatory social service generated greater dissatisfaction. The Ministry of Health of Ecuador, as an organizational entity, should implement improvements to increase the job satisfaction of recently graduated physicians, given the implications that this experience may have for their professional future.
Does Central Sensitization Influence Outcomes of Lumbar Discectomy Surgery in Patients With Lumbar Disc Herniation? A Multicenter Prospective Study
Authors: Yamada Junichi , Akeda Koji , Takegami Norihiko , Fujiwara Tatsuhiko , Murata Koichiro , Kono Toshibumi , Sudo Takao , Imanishi Takao , Kurata Tatsuya , Kawakita Eiji , Sakakibara Toshihiko , Kondo Tetsushi , Takegami Kenji , Sato Masayoshi , Sudo Akihiro 
Published: June 2023

Study Design Multicenter prospective study. Objective Patients with central sensitization (CS) are reported to be at high risk of poor outcomes after spinal surgery. However, the influence of CS on surgical outcomes for lumbar disc herniation (LDH) remains unknown. This study aimed to examine the association between preoperative CS and surgical outcomes in LDH patients. Methods A total of 100 consecutive patients with LDH (mean age 51.2) who underwent lumbar surgery were included in this study. The extent of CS was evaluated using the central sensitization inventory (CSI), a screening tool for CS-related symptoms. The patients completed the following CSI and clinical outcome assessments (COAs) preoperatively and 12 months postoperatively: the Japanese Orthopaedic Association (JOA) score for back pain, JOA back pain evaluation questionnaire (JOABPEQ), and Oswestry Disability Index (ODI). The association between preoperative CSI scores, and preoperative and postoperative COAs was analyzed, and the postoperative changes were statistically evaluated. Results The preoperative CSI score significantly decreased 12 months postoperatively. Preoperative CSI scores showed a significant correlation with most COAs; however, a significant correlation was only identified in the social function and mental health domains of JOABPEC postoperatively. Higher preoperative CSI showed worse preoperative COAs; however, all COAs significantly improved regardless of CSI severity. There were no significant differences in any COAs among the CSI severity groups 12 months postoperatively. Conclusions The results of this study showed that lumbar surgeries significantly improved the COAs regardless of preoperative severity of CS in patients with LDH.
BRD4 inhibition sensitizes diffuse large B-cell lymphoma cells to ferroptosis
Authors: Schmitt Anja , Grimm Melanie , Kreienkamp Nina , Junge Hannah , Labisch Jan , Schuhknecht Laurentz , Schönfeld Caroline , Görsch Elsa , Tibello Alessia , Menck Kerstin , Bleckmann Annalen , Lengerke Claudia , Rosenbauer Frank , Grau Michael , Zampieri Mattia , Schulze-Osthoff Klaus , Klener Pavel , Dolnikova Alexandra , Lenz Georg , Hailfinger Stephan 
Published: June 2023

Abstract
Diffuse large B-cell lymphoma (DLBCL), the most common form of non-Hodgkin lymphoma, is characterized by an aggressive clinical course. In approximately one-third of patients with DLBCL, first-line multiagent immunochemotherapy fails to produce a durable response. Molecular heterogeneity and apoptosis resistance pose major therapeutic challenges in DLBCL treatment. To circumvent apoptosis resistance, the induction of ferroptosis might represent a promising strategy for lymphoma therapy. In this study, a compound library, targeting epigenetic modulators, was screened to identify ferroptosis-sensitizing drugs. Strikingly, bromodomain and extra-terminal domain (BET) inhibitors sensitized cells of the germinal center B-cell–like (GCB) subtype of DLBCL to ferroptosis induction and the combination of BET inhibitors with ferroptosis inducers, such as dimethyl fumarate or RSL3, synergized in the killing of DLBCL cells in vitro and in vivo. On the molecular level, the BET protein BRD4 was found to be an essential regulator of ferroptosis suppressor protein 1 expression and thus to protect GCB-DLBCL cells from ferroptosis. Collectively, we identified and characterized BRD4 as an important player in ferroptosis suppression in GCB-DLBCL and provide a rationale for the combination of BET inhibitors with ferroptosis-inducing agents as a novel therapeutic approach for DLBCL treatment.
Safety and efficacy of an anti–human APC antibody for prophylaxis of congenital factor deficiencies in preclinical models
Authors: Jiang Miao , Yang Fei , Jiang Yizhi , Cheng Lu , Han Jingjing , Yi Jiawei , Zuo Bin , Huang Lulu , Ma Zhenni , Li Tianyi , Cao Lijuan J. , Xia Zhisong , Bai Xia , Jia Chenjun , Yang Teddy Tat Chi , Esmon Naomi L. , Ruan Changgeng , Xia Lijun , Esmon Charles T. , Han Yue , Wu Depei , Xu Jun 
Published: June 2023

Abstract
Rebalance of coagulation and anticoagulation to achieve a hemostatic effect has recently gained attention as an alternative therapeutic strategy for hemophilia. We engineered a humanized chimeric antibody, SR604, based on a previously published murine antibody, HAPC1573, which selectively blocks the anticoagulant activity of human activated protein C (APC). SR604 effectively blocked the anticoagulation activities of APC in human plasma deficient in various coagulation factors in vitro with affinities ∼60 times greater than that of HAPC1573. SR604 exhibited prophylactic and therapeutic efficacy in the tail-bleeding and knee-injury models of hemophilia A and B mice expressing human APC (humanized hemophilic mice). SR604 did not interfere with the cytoprotection and endothelial barrier function of APC, nor were there obvious toxicity effects in humanized hemophilic mice. Pharmacokinetic study showed a high bioavailability (106%) of subcutaneously injected SR604 in cynomolgus monkeys. These results demonstrate that SR604 is expected to be a safe and effective therapeutic and/or prophylactic agent with a prolonged half-life for patients with congenital factor deficiencies including hemophilia A and B.
Possibility for detecting 14 typical odorants occurring in drinking water by employing human odor-binding protein OBP2a
Authors: Chang Xinying , Qiu Fuguo , Wang Chunmiao , Qian Yaohan , Zhang Yongxin , Guo Qingyuan , Wang Qi , Wang Shihao , Yang Min , Yu Jianwei 
Published: June 2023

AbstractOdor issues occurring in drinking water have been a big challenge to face for water suppliers globally, which highly commend to develop quick or on-site odor detection tools for the management of odor problems. Olfactory sensors based on odor-binding proteins (OBPs) have been utilized to analyze pollutants in food and air samples, while their application for the detection of typical odor-causing compounds in drinking water is rarely reported, partly due to the lack of knowledge about the binding properties of odorants. In this study, the binding affinity and mechanism of human odor-binding protein OBP2a to 14 typical odorants in water were first assessed using fluorescent competitive binding assays and molecular docking techniques. The 14 odorants include 7 aldehydes, 2 terpenes, 2 thioethers, bis(2-chloro-1-methylethyl) ether (DCIP), 2-ethyl-4-methyl-1,3-dioxolane (2E4MDL), and 2-isobutyl-3-methoxypyrazine (IBMP). The results showed that OBP2a could bind to 9 odorants (Ki = 29.91 μmol/L–48.36 μmol/L), including IBMP, 2-MIB, and six aldehydes (hexanal, heptanal, benzaldehyde, 2-octenal, decanal, and β-cyclocitral), among which stronger binding affinity for aldehydes is observed (Ki = 29.91 μmol/L–43.87 μmol/L). Molecular docking confirmed that Lys112 and Phe97 are major amino acid residues involved in the binding of the most target odorants. To be specific, IBMP and aldehydes can form hydrogen bonds with Lys112; aromatic ring-containing odorants such as IBMP and benzaldehyde can also form pi–pi stacking with Phe97. The binding affinity of OBP2a to fatty aldehydes including hexanal, heptanal, 2-octenal, decanal, and β-cyclocitral increased with the increase of hydrophobicity of aldehydes. The valuable information to the binding of OBP2a to typical odorants in this study would provide a theoretical foundation for the development of OBP-based odor detection biosensors to achieve quick detection in drinking water, further helping the improvement of water treatment processes in the water industry.
Graphical Abstract
Early child care and the employment potential of mothers: evidence from semi-parametric difference-in-differences estimation
Authors: Zimmert Franziska 
Published: June 2023

AbstractThis paper examines the effect of an expansion of subsidized early child care on maternal labor market outcomes. It contributes to the literature by analyzing, apart from the employment rate, the adjustment of agreed working hours and especially of preferred working hours. Semi-parametric difference-in-differences estimation based on survey data from the German Microcensus results in positive effects on the employment rate, as well as on agreed and preferred working hours by up to 20% of the pre-reform mean. As agreed and preferred working hours adjust in line with each other, the expansion of early child care can tap labor market potentials beyond those of currently underemployed mothers. Moreover, conditional effects show that especially better educated and non-single mothers respond to the reform.
3DVizSNP: a tool for rapidly visualizing missense mutations identified in high throughput experiments in iCn3D
Authors: Sierk Michael , Ratnayake Shashikala , Wagle Manoj M. , Chen Ben , Park Brian , Wang Jiyao , Youkharibache Philippe , Meerzaman Daoud 
Published: June 2023

Abstract
Background
High throughput experiments in cancer and other areas of genomic research identify large numbers of sequence variants that need to be evaluated for phenotypic impact. While many tools exist to score the likely impact of single nucleotide polymorphisms (SNPs) based on sequence alone, the three-dimensional structural environment is essential for understanding the biological impact of a nonsynonymous mutation.

Results
We present a program, 3DVizSNP, that enables the rapid visualization of nonsynonymous missense mutations extracted from a variant caller format file using the web-based iCn3D visualization platform. The program, written in Python, leverages REST APIs and can be run locally without installing any other software or databases, or from a webserver hosted by the National Cancer Institute. It automatically selects the appropriate experimental structure from the Protein Data Bank, if available, or the predicted structure from the AlphaFold database, enabling users to rapidly screen SNPs based on their local structural environment. 3DVizSNP leverages iCn3D annotations and its structural analysis functions to assess changes in structural contacts associated with mutations.

Conclusions
This tool enables researchers to efficiently make use of 3D structural information to prioritize mutations for further computational and experimental impact assessment. The program is available as a webserver at https://analysistools.cancer.gov/3dvizsnp or as a standalone python program at https://github.com/CBIIT-CGBB/3DVizSNP.
Effects of new hypoglycemic drugs on cardiac remodeling: a systematic review and network meta-analysis
Authors: Huang Yi-lin , Xu Xiao-zhuo , Liu Jing , Wang Pin-yao , Wang Xue-li , Feng Hong-lin , Liu Cheng-jiang , Han Xu 
Published: June 2023

Abstract
Background
In recent years, the incidence of diabetes mellitus has been increasing annually, and cardiovascular complications secondary to diabetes mellitus have become the leading cause of death in diabetic patients. Considering the high incidence of type 2 diabetes (T2DM) combined with cardiovascular disease (CVD), some new hypoglycemic agents with cardiovascular protective effects have attracted extensive attention. However, the specific role of these regimens in ventricular remodeling remains unknown. The purpose of this network meta-analysis was to compare the effects of sodium glucose cotransporter type 2 inhibitor (SGLT-2i), glucagon-like peptide 1 receptor agonist (GLP-1RA) and dipeptidyl peptidase-4 inhibitor (DPP-4i) on ventricular remodeling in patients with T2DM and/or CVD.

Methods
Articles published prior to 24 August 2022 were retrieved in four electronic databases: the Cochrane Library, Embase, PubMed, and Web of Science. This meta-analysis included randomized controlled trials (RCTs) and a small number of cohort studies. The differences in mean changes of left ventricular ultrasonic parameters between the treatment and control groups were compared.

Results
A total of 31 RCTs and 4 cohort studies involving 4322 patients were analyzed. GLP-1RA was more significantly associated with improvement in left ventricular end-systolic diameter (LVESD) [MD = -0.38 mm, 95% CI (-0.66, -0.10)] and LV mass index (LVMI) [MD = -1.07 g/m2, 95% CI (-1.71, -0.42)], but significantly decreased e' [MD = -0.43 cm/s 95% CI (-0.81, -0.04)]. DPP-4i was more strongly associated with improvement in e' [MD = 3.82 cm/s, 95% CI (2.92,4.7)] and E/e'[MD = -5.97 95% CI (-10.35, -1.59)], but significantly inhibited LV ejection fraction (LVEF) [MD = -0.89% 95% CI (-1.76, -0.03)]. SGLT-2i significantly improved LVMI [MD = -0.28 g/m2, 95% CI (-0.43, -0.12)] and LV end-diastolic diameter (LVEDD) [MD = -0.72 ml, 95% CI (-1.30, -0.14)] in the overall population, as well as E/e' and SBP in T2DM patients combined with CVD, without showing any negative effect on left ventricular function.

Conclusion
The results of the network meta-analysis provided high certainty to suggest that SGLT-2i may be more effective in cardiac remodeling compared to GLP-1RA and DPP-4i. While GLP-1RA and DPP-4i may have a tendency to improve cardiac systolic and diastolic function respectively. SGLT-2i is the most recommended drug for reversing ventricular remodeling in this meta-analysis.
Role of the immune system in amyotrophic lateral sclerosis. Analysis of the natural killer cells and other circulating lymphocytes in a cohort of ALS patients
Authors: Piccoli Tommaso , Castro Francesca , La Bella Vincenzo , Meraviglia Serena , Di Simone Marta , Salemi Giuseppe , Dieli Francesco , Spataro Rossella 
Published: June 2023

Abstract
Aims
Neuroinflammation might be involved in the degeneration and progression of Amyotrophic Lateral Sclerosis (ALS). Here, we studied the role of the circulating lymphocytes in ALS, in particular the NK cells. We focused on the relationship between blood lymphocytes, ALS clinical subtype and disease severity.

Subjects and Methods
Blood samples were collected from 92 patients with sporadic ALS, 21 patients with Primary Lateral Sclerosis (PLS) and 37 patients affected by primary progressive multiple sclerosis (PPMS) with inactive plaques. Blood was taken from ALS and controls at the time of diagnosis/referral. Circulating lymphocytes were analyzed by flow cytometry with specific antibodies. Values were expressed as absolute number (n°/µl) of viable lymphocytes subpopulations in ALS were compared with controls. Multivariable analysis was made using site of onset, gender changes in ALSFRS-R and disease progression rate (calculated as ΔFS score).

Results
Age at onset was 65y (58–71) in ALS (spinal 67.4%; bulbar, 32.6%), 57y (48–78) in PLS and 56y (44–68) PPMS. Absolute blood levels of the lymphocytes in the different cohorts were within normal range. Furthermore, while levels of lymphocytes T and B were not different between disease groups, NK cells were increased in the ALS cohort (ALS = 236 [158–360] vs. Controls = 174[113–240], p < 0.001). In ALS, blood levels of NK cells were not related with the main clinical-demographic variables, including the rate of disease progression. Multivariable analysis suggested that male gender and bulbar onset were independently associated with a risk of high blood NK cells levels.

Conclusions
We show that blood NK cells are selectively increased in ALS, though their level appear unaffected in patients with an estimated rapidly progressing disease. Being of a male gender and with a bulbar onset seems to confer higher susceptibility to have increased NK lymphocytes levels at diagnosis/referral. Our experiments provides a further clear-cut evidence of the role of the NK lymphocytes as a significant player in ALS pathogenesis.
Secondary polycythaemia from chronic hypoxia is a risk for cerebral thrombosis: a case report
Authors: Zhou Min , Liu Xiaoxia , Li Li 
Published: June 2023

Abstract
Background
Secondary polycythemia is considered the usual complication of chronic hypoxia. It can theoretically increase the oxygen-carrying capacity, but this adaptive trait has a deleterious effect because the blood viscosity increases, which can induce significant morbidity and mortality, such as stroke and myocardial infarction.

Case presentation
A 55-year-old man with a history of a congenitally small main pulmonary artery presented to the emergency department with sustained unsteady walking, dizziness and vertigo. Evaluation revealed elevated hemoglobin and superior posterior circulation cerebral artery thrombosis. The patient was treated with high flux inhalation of oxygen and anti-platelet aggregation.

Conclusions
The involvement of cerebral vessels has rarely been reported in chronic hypoxia cases. The present case is the first case of superior posterior circulation cerebral artery thrombosis due to chronic hypoxia in a patient with a congenitally small main pulmonary artery. This case demonstrates the importance of recognizing some chronic diseases that can lead to hypoxia and secondary polycythemia thereby leading to hypercoagulable state and subsequent thrombosis.
Prognostic value of tumor necrosis based on the evaluation of frequency in invasive breast cancer
Authors: Chen Jianhua , Li Zhijun , Han Zhonghua , Kang Deyong , Ma Jianli , Yi Yu , Fu Fangmeng , Guo Wenhui , Zheng Liqin , Xi Gangqin , He Jiajia , Qiu Lida , Li Lianhuang , Zhang Qingyuan , Wang Chuan , Chen Jianxin 
Published: June 2023

Abstract
Background
Tumor necrosis (TN) was associated with poor prognosis. However, the traditional classification of TN ignored spatial intratumor heterogeneity, which may be associated with important prognosis. The purpose of this study was to propose a new method to reveal the hidden prognostic value of spatial heterogeneity of TN in invasive breast cancer (IBC).

Methods
Multiphoton microscopy (MPM) was used to obtain multiphoton images from 471 patients. According to the relative spatial positions of TN, tumor cells, collagen fibers and myoepithelium, four spatial heterogeneities of TN (TN1-4) were defined. Based on the frequency of individual TN, TN-score was obtained to investigate the prognostic value of TN.

Results
Patients with high-risk TN had worse 5-year disease-free survival (DFS) than patients with no necrosis (32.5% vs. 64.7%; P < 0.0001 in training set; 45.8% vs. 70.8%; P = 0.017 in validation set), while patients with low-risk TN had a 5-year DFS comparable to patients with no necrosis (60.0% vs. 64.7%; P = 0.497 in training set; 59.8% vs. 70.8%; P = 0.121 in validation set). Furthermore, high-risk TN “up-staged” the patients with IBC. Patients with high-risk TN and stage I tumors had a 5-year DFS comparable to patients with stage II tumors (55.6% vs. 62.0%; P = 0.565 in training set; 62.5% vs. 66.3%; P = 0.856 in validation set), as well as patients with high-risk TN and stage II tumors had a 5-year DFS comparable to patients with stage III tumors (33.3% vs. 24.6%; P = 0.271 in training set; 44.4% vs. 39.3%; P = 0.519 in validation set).

Conclusions
TN-score was an independent prognostic factor for 5-year DFS. Only high-risk TN was associated with poor prognosis. High-risk TN “up-staged” the patients with IBC. Incorporating TN-score into staging category could improve its performance to stratify patients.