bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perbandingan Sistem Wakaf Sebagai Implementasi Kebijakan Distribusi Sosial (Studi Kasus: Arab Saudi Dan Malaysia)
Authors: Muis Afni Regita Cahyani , Putri Mia Utami , Amalia Zahra , Khalifah Nanda Putri , Faatimah Faatimah 
Published: August 2023

This article will explain the comparison of waqf systems in Malaysia and Saudi Arabia. Each country has a different waqf management system that supports social distribution policies. Malaysia is managed by the State Islamic Religious Council, as Malaysia is a federal country and each state has a Waqf Management Committee to manage waqf assets. Saudi Arabia is managed by a special institution called the Higher Waqf Council, chaired by the Minister of Hajj and Waqf, with the authority to distribute waqf assets according to the mandate given by the waqif. This study uses a comparative method by analyzing two objects which then result in similarities and differences in the waqf system to find social distribution policy factors and their implementation. This study uses a qualitative-descriptive method with secondary analysis, namely using secondary data such as journals and official websites. The results of this study show that the management of waqf is different in each organization in their respective countries and has different authorities, but the results still make waqf as one of the policies made by the government for their country.

Artikel ini akan menjelaskan perbandingan sistem wakaf di negara Malaysia dan Arab Saudi. Setiap negara memiliki sistem pengelolaan wakaf berbeda yang mendukung kebijakan distribusi sosial. Malaysia dikelola oleh Dewan Agama Islam Negara, karena Malaysia adalah negara federal dan setiap negara memiliki SIRC untuk mengelola wakaf. Arab Saudi yang dikelola oleh lembaga khusus yang disebut Majelis Tinggi Wakaf diketuai oleh Menteri Haji dan Wakaf, dengan kewenangan untuk mendistribusikan aset wakaf sesuai mandat yang diberikan oleh wakif. Penelitian ini menggunakan metode komparatif dengan menganalisis dua objek yang kemudian menghasilkan persamaan dan perbedaan sistem wakaf untuk menemukan faktor-faktor kebijakan distribusi sosial dan implementasinya. Penelitian ini menggunakan metode kualitatif-deskriptif dengan secondary analysis, yaitu menggunakan data sekunder, seperti jurnal-jurnal dan official website. Hasil dari penelitian ini adalah bahwa dalam pengelolaan wakaf yang dikelola oleh masing-masing organisasi di negaranya dan memiliki kewenangan yang berbeda-beda namun hasilnya tetap menjadikan wakaf sebagai salah satu kebijakan yang dibuat oleh pemerintah untuk negaranya.
IMPLEMENTASI PEMBIMBINGAN DAN PENGAWASAN PK BAPAS TERHADAP PERUBAHAN PERILAKU KLIEN PEMASYARAKATAN YANG MELAKUKAN PELANGGARAN HUKUM KEMBALI (Studi kasus di Balai Pemasyarakatan Kelas II Kediri)
Authors: Setiasih Idha Wening , Nurbaedah Nurbaedah 
Published: August 2023

The purpose of this study was to analyze the implementation of the guidance and supervision of Probation Officer according to Law Number 12 of 1995 concerning Corrections and Regulation of the Government of the Republic of Indonesia Number 31 of 1999 concerning the Coaching and Guidance of Correctional Assisted Citizens against changes in the behavior of correctional clients who break the law again, to analyze the obstacles faced by the Probation Officer in guiding and supervising correctional clients who break the law again. The location of this study is the Class II Penitentiary (Bapas) Kediri which is located at Penanggungan street, no. 19, Kediri City, East Java, with a total of 13 respondents using the purposive sampling method with qualitative data analysis and data collection techniques using primary data and secondary data obtained by structured interviews, in-depth interviews, observation, and documentation. The result of this study is that the guidance and supervision of Probation Officer on the behavior of correctional clients has been effective as seen from Law Number 12 of 1995 concerning Corrections and Regulation of the Government of the Republic of Indonesia Number 31 of 1999 concerning the Coaching and Guidance of Correctional Assisted Citizens because almost all of these regulations have been carried out and implemented by the Probation Officer, However, when viewed from the behavior of correctional clients, the guidance and supervision of the Probation Officer has not been fully effective because there has been no change in the behavior of correctional clients who are still breaking the law.. The factors that become obstacles for the Penitentiary (Bapas) Kediri in carrying out guidance tasks for correctional clients are a) Penitentiary regulations, b) Penitentiary personnel, c) Infrastructure, d) Personal, from correctional clients and the family., and e) Cost.
TINJAUAN YURIDIS TERHADAP PEMBUKTIAN HARTA BERSAMA DALAM PUTUSAN NOMOR 0133/Pdt.G/2016/PA.Kdr
Authors: Kumala Nirvana Rifka Dian , Fahrazi Mahfud 
Published: August 2023

This master thesis is about the joint property’s evidence of the verdict number 0133/Pdt.G/2016/PA.Kdr. The evidences that submitted by defendant counterclaim were an authentic deed and two witnesses who are siblings of the defendant counterclaim, so according to that the judges decided to share the joint property of marriage againts the Compilation of Islam Law Section 97. The purposes of this master thesis are to analyze the validity of the evidences in joint property’s evidence and to analyze the judge’s considerations of the verdict number 0133/Pdt.G/2016/PA.Kdr. This master thesis is a normative research. This master thesis concludes that the validity of the evidences in joint property’s evidence of the verdrict number 0133/Pdt.G/2016/PA.Kdr according to Section 145 of HIR, Section 172 of RBg and Section 1910 of Indonesian Civil Code, plaintiff counterclaim submitted an authentic deed and two witnesses as evidences so both of them were valid as evidences. And then the evidences that submited by defendant counterclaim were an authentic deed and two witnesses who are the siblings of defendant counterclaim, so that the two witnesses that submitted by defendant counterclaim does not fulfill the formal requirement of evidence based on the codes. The verdict does not fulfill the elements of legal certainty.
TINJAUAN YURIDIS TERHADAP PUTUSAN BEBAS VRIJSPRAAK TINDAK PIDANA ASUSILA DI PENGADILAN NEGERI JOMBANG (Studi Putusan Perkara Nomor: 131/Pid.B/2021/Pn.Jbg)
Authors: Ajikirana Shafir Karisma , Karyoto Karyoto 
Published: August 2023

Penelitian ini berangkat dari maraknya kasus tindak pidana asusila yang terjadi di kabupaten jombang, terdapat satu kasus tindak pidana asusila yang mana hakim memberikan putusan bebas terhadap terdakwa. Dari hal ini melahirkan rumusan masalah terkait apa yang menjadi pertimbangan hakim dalam memberikan putusan bebas dan bagaimana aspek keadilan terhadap putusan hakim. adapun metodologi penelitian yang digunakan pada penelitian adalah metode penelitian empiris dengan menggunakan pendekatan normatif, teknik pengumpulan data menggunakan wawancara dan kajian kepustakaan, sedangkan teknik analisis data menggunakan metode Induktif yaitu metode dari khusus ke umum. Hasil penelitian ini menunjukan bahwa jaksa penuntut umum hanya membacakan dakwaan ketiga dari total tiga dakwaan yang didakwakan kepada terdakwa, lalu kuasa hukum terdakwa memberikan pembelaan atau pledoi yang menitik beratkan pada dakwaan jaksa penuntut umum yang mana diperoleh bukti bahwa dalam kasus ini terdakwa tidak bisa didakwa atas dakwaan yang diberikan karna menurut kuasa hukum dakwaan tersebut tidak tepat dan hakim memberikan putusan bebas terhadap terdakwa atas pertimbangan tersebut.
Accounting similarities, sophisticated investors, relevance and information asymmetry
Authors: Azarberahman Alireza , Pakdelan Saeed , Tohidinia Malihe 
Published: August 2023

Information asymmetry is a phenomenon in the capital market that can be caused by various factors. The purpose of this paper is to contribute to the debate on whether information asymmetry can be affected by factors such as accounting comparability, sophisticated investors, and relevance, and therefore, its value-relevance for decision-making. The paper uses three methods criteria for information asymmetry (VOLTRADE, PNSY and bid-ask spread) as well as two methods for measuring accounting comparability (text mining and De-Franco). Therefore, it is feasible to test and compare different methods of accounting comparability with different methods of information asymmetry. The results of the study indicate that the comparability of accounting practises has a notable adverse impact on information asymmetry. Additionally, it was observed that sophisticated investors have the ability to moderate this relationship. We find that relevance has significant relation with information asymmetry. Furthermore, it has been determined that comparability exerts a substantial influence on information asymmetry within an imperfectly competitive market, as opposed to a market characterised by perfect competition. Therefore, these findings underscore the significance of considering market conditions and competition levels in the issue. Ultimately, our findings indicate that the cash flow component of comparability exerts a notable impact on information asymmetry, in contrast to the accrual component. This study provides new insights regarding the nexus between accounting comparability and financial asymmetry.
Pathogenesis and distribution of infective endocarditis in the pediatric population: a 20-year experience in a tertiary care center in a developing country
Authors: Rashed Moustafa , Fakhri Ghina , Zareef Rana , Abdul Halim Nour , Ahmed Mohamed , Dbaibo Ghassan , El-Rassi Issam , Bitar Fadi , Arabi Mariam Toufic 
Published: August 2023

IntroductionInfective endocarditis is an infection of the endothelial surfaces of the heart. It is more prevalent in adults but its incidence in the pediatric population has been on the rise. The most important factor remains congenital heart disease and the most isolated pathogen is viridans group streptococcus.MethodsIn this manuscript, we present a 20-year experience of a major referral tertiary care center in diagnosing and treating pediatric patients with endocarditis. A retrospective analysis of records of patients who were diagnosed with infective endocarditis under the age of 18 years is presented in this study. Variables relating to the demographic, imaging, microbiologic and pathologic data are described. Outcomes relating to complications and need for surgical repair are also portrayed.ResultsA total of 70 pediatric patients were diagnosed with endocarditis in this time interval. The medical records of 65 patients were comprehensively reviewed, however the remaining 5 patients had severely missing data. Of the 65 patients, 55.4% were males, and the mean age at diagnosis was 7.12 years. More than half of the population (58.5%) had vegetation evident on echocardiography. The pulmonary valve was the most commonly affected (50%), followed by the mitral valve and tricuspid valves (15.6%). Most patients received empiric treatment with vancomycin and gentamicin. Viridans group streptococcus was the most frequently isolated organism (23.4%).ConclusionAmong pediatric patients diagnosed with endocarditis in this study, data pertaining to valve involvement and microbiologic information was consistent with the published literature. The incidence of complications and the need for surgical repair are not significantly correlated with demographic and clinical variables.
The HLA class I immunopeptidomes of AAV capsid proteins
Authors: Brito-Sierra Carlos A. , Lannan Megan B. , Malherbe Laurent P. , Siegel Robert W. 
Published: August 2023

IntroductionCellular immune responses against AAV vector capsid represent an obstacle for successful gene therapy. Previous studies have used overlapping peptides spanning the entire capsid sequence to identify T cell epitopes recognized by AAV-specific CD8+ T cells. However, the repertoire of peptides naturally displayed by HLA class I molecules for CD8 T cell recognition is unknown.MethodsUsing mRNA transfected monocyte-derived dendritic cells (MDDCs) and MHC-associated peptide proteomics (MAPPs), we identified the HLA class I immunopeptidomes of AAV2, AAV6 and AAV9 capsids. MDDCs were isolated from a panel of healthy donors that have diverse alleles across the US population. mRNA-transfected MDDCs were lysed, the peptide:HLA complexes immunoprecipitated, and peptides eluted and analyzed by mass spectrometry.ResultsWe identified 65 AAV capsid-derived peptides loaded on HLA class I molecules of mRNA transfected monocyte derived dendritic cells. The HLA class I peptides are distributed along the entire capsid and more than 60% are contained within HLA class II clusters. Most of the peptides are organized as single species, however we identified twelve clusters containing at least 2 peptides of different lengths. Only 9% of the identified peptides have been previously identified as T cell epitopes, demonstrating that the immunogenicity potential for the vast majority of the AAV HLA class I immunopeptidome remains uncharacterized. In contrast, 12 immunogenic epitopes identified before were not found to be naturally processed in our study. Remarkably, 11 naturally presented AAV peptides were highly conserved among the three serotypes analyzed suggesting the possibility of cross-reactive AAV-specific CD8 T cells.DiscussionThis work is the first comprehensive study identifying the naturally displayed HLA class I peptides derived from the capsid of AAVs. The results from this study can be used to generate strategies to assess immunogenicity risk and cross-reactivity among serotypes during gene therapies.
DNA methylation patterns in CD4+ T-cells separate psoriasis patients from healthy controls, and skin psoriasis from psoriatic arthritis
Authors: Natoli Valentina , Charras Amandine , Hofmann Sigrun R. , Northey Sarah , Russ Susanne , Schulze Felix , McCann Liza , Abraham Susanne , Hedrich Christian M. 
Published: August 2023

BackgroundPsoriasis is an autoimmune/inflammatory disorder primarily affecting the skin. Chronic joint inflammation triggers the diagnosis of psoriatic arthritis (PsA) in approximately one-third of psoriasis patients. Although joint disease typically follows the onset of skin psoriasis, in around 15% of cases it is the initial presentation, which can result in diagnostic delays. The pathophysiological mechanisms underlying psoriasis and PsA are not yet fully understood, but there is evidence pointing towards epigenetic dysregulation involving CD4+ and CD8+ T-cells.ObjectivesThe aim of this study was to investigate disease-associated DNA methylation patterns in CD4+ T-cells from psoriasis and PsA patients that may represent potential diagnostic and/or prognostic biomarkers.MethodsPBMCs were collected from 12 patients with chronic plaque psoriasis and 8 PsA patients, and 8 healthy controls. CD4+ T-cells were separated through FACS sorting, and DNA methylation profiling was performed (Illumina EPIC850K arrays). Bioinformatic analyses, including gene ontology (GO) and KEGG pathway analysis, were performed using R. To identify genes under the control of interferon (IFN), the Interferome database was consulted, and DNA Methylation Scores were calculated.ResultsNumbers and proportions of CD4+ T-cell subsets (naïve, central memory, effector memory, CD45RA re-expressing effector memory cells) did not vary between controls, skin psoriasis and PsA patients. 883 differentially methylated positions (DMPs) affecting 548 genes were identified between controls and “all” psoriasis patients. Principal component and partial least-squares discriminant analysis separated controls from skin psoriasis and PsA patients. GO analysis considering promoter DMPs delivered hypermethylation of genes involved in “regulation of wound healing, spreading of epidermal cells”, “negative regulation of cell-substrate junction organization” and “negative regulation of focal adhesion assembly”. Comparing controls and “all” psoriasis, a majority of DMPs mapped to IFN-related genes (69.2%). Notably, DNA methylation profiles also distinguished skin psoriasis from PsA patients (2,949 DMPs/1,084 genes) through genes affecting “cAMP-dependent protein kinase inhibitor activity” and “cAMP-dependent protein kinase regulator activity”. Treatment with cytokine inhibitors (IL-17/TNF) corrected DNA methylation patterns of IL-17/TNF-associated genes, and methylation scores correlated with skin disease activity scores (PASI).ConclusionDNA methylation profiles in CD4+ T-cells discriminate between skin psoriasis and PsA. DNA methylation signatures may be applied for quantification of disease activity and patient stratification towards individualized treatment.
Role of radiomics in predicting lymph node metastasis in gastric cancer: a systematic review
Authors: Miccichè Francesco , Rizzo Gianluca , Casà Calogero , Leone Mariavittoria , Quero Giuseppe , Boldrini Luca , Bulajic Milutin , Corsi Domenico Cristiano , Tondolo Vincenzo 
Published: August 2023

IntroductionGastric cancer (GC) is an aggressive and clinically heterogeneous tumor, and better risk stratification of lymph node metastasis (LNM) could lead to personalized treatments. The role of radiomics in the prediction of nodal involvement in GC has not yet been systematically assessed. This study aims to assess the role of radiomics in the prediction of LNM in GC.MethodsA PubMed/MEDLINE systematic review was conducted to assess the role of radiomics in LNM. The inclusion criteria were as follows: i. original articles, ii. articles on radiomics, and iii. articles on LNM prediction in GC. All articles were selected and analyzed by a multidisciplinary board of two radiation oncologists and one surgeon, under the supervision of one radiation oncologist, one surgeon, and one medical oncologist.ResultsA total of 171 studies were obtained using the search strategy mentioned on PubMed. After the complete selection process, a total of 20 papers were considered eligible for the analysis of the results. Radiomics methods were applied in GC to assess the LNM risk. The number of patients, imaging modalities, type of predictive models, number of radiomics features, TRIPOD classification, and performances of the models were reported.ConclusionsRadiomics seems to be a promising approach for evaluating the risk of LNM in GC. Further and larger studies are required to evaluate the clinical impact of the inclusion of radiomics in a comprehensive decision support system (DSS) for GC.
Hospital length of stay prediction tools for all hospital admissions and general medicine populations: systematic review and meta-analysis
Authors: Gokhale Swapna , Taylor David , Gill Jaskirath , Hu Yanan , Zeps Nikolajs , Lequertier Vincent , Prado Luis , Teede Helena , Enticott Joanne 
Published: August 2023

BackgroundUnwarranted extended length of stay (LOS) increases the risk of hospital-acquired complications, morbidity, and all-cause mortality and needs to be recognized and addressed proactively.ObjectiveThis systematic review aimed to identify validated prediction variables and methods used in tools that predict the risk of prolonged LOS in all hospital admissions and specifically General Medicine (GenMed) admissions.MethodLOS prediction tools published since 2010 were identified in five major research databases. The main outcomes were model performance metrics, prediction variables, and level of validation. Meta-analysis was completed for validated models. The risk of bias was assessed using the PROBAST checklist.ResultsOverall, 25 all admission studies and 14 GenMed studies were identified. Statistical and machine learning methods were used almost equally in both groups. Calibration metrics were reported infrequently, with only 2 of 39 studies performing external validation. Meta-analysis of all admissions validation studies revealed a 95% prediction interval for theta of 0.596 to 0.798 for the area under the curve. Important predictor categories were co-morbidity diagnoses and illness severity risk scores, demographics, and admission characteristics. Overall study quality was deemed low due to poor data processing and analysis reporting.ConclusionTo the best of our knowledge, this is the first systematic review assessing the quality of risk prediction models for hospital LOS in GenMed and all admissions groups. Notably, both machine learning and statistical modeling demonstrated good predictive performance, but models were infrequently externally validated and had poor overall study quality. Moving forward, a focus on quality methods by the adoption of existing guidelines and external validation is needed before clinical application.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42021272198.
Probiotic Escherichia coli Nissle 1917-derived outer membrane vesicles modulate the intestinal microbiome and host gut-liver metabolome in obese and diabetic mice
Authors: Shi Jun , Ma DongXue , Gao ShanHu , Long Fei , Wang Xin , Pu XingYu , Cannon Richard D. , Han Ting-Li 
Published: August 2023

IntroductionObesity and diabetes are common chronic metabolic disorders which can cause an imbalance of the intestinal flora and gut-liver metabolism. Several studies have shown that probiotics, includingEscherichia coliNissle 1917 (EcN), promote microbial balance and metabolic health. However, there are no studies on how EcN outer membrane vesicles (EcN-OMVs) influence the intestinal microflora and affect the metabolic disorders of obesity and diabetes.MethodsIn this study, we evaluated the effects of EcN-OMVs on high-fat diet (HFD)-induced obesity and HFD + streptozotocin (STZ)-induced diabetes.ResultsEcN-OMVs could reduce body weight, decrease blood glucose, and increase plasma insulin in obese mice. Similarly, EcN-OMVs treatment could modify the ratio ofFirmicutes/Bacteroidetesin the gut, elevate intestinal short-chain fatty acid (SCFA)-producing flora, and influence the SCFA content of the intestine. Furthermore, the intestinal metabolites ornithine and fumaric acid, hepatic ω-6 unsaturated fatty acids, and SCFAs were significantly increased after administering EcN-OMVs.DiscussionOverall, this study showed that EcN-OMVs might act as post-biotic agents that could modulate gut-liver metabolism and ameliorate the pathophysiology of obesity and diabetes.