bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II dose titration study of regorafenib in progressive unresectable metastatic colorectal cancer
Authors: Kato Takeshi , Kudo Toshihiro , Kagawa Yoshinori , Murata Kohei , Ota Hirofumi , Noura Shingo , Hasegawa Junichi , Tamagawa Hiroshi , Ohta Katsuya , Ikenaga Masakazu , Miyazaki Susumu , Komori Takamichi , Uemura Mamoru , Nishimura Junichi , Hata Taishi , Matsuda Chu , Satoh Taroh , Mizushima Tsunekazu , Ohno Yuko , Yamamoto Hirofumi , Doki Yuichiro , Eguchi Hidetoshi 
Published: February 2023

AbstractRegorafenib has shown significant survival benefit as a salvage therapy for colorectal cancer; however, its starting dose has been controversial in recent studies. Therefore, we conducted a prospective study on the efficacy and safety of the dose reduction of regorafenib to 120 mg. Patients received 120 mg regorafenib once per day for 3 weeks, followed by a 1-week off-treatment period. The primary endpoint was the investigator-assessed disease control rate (DCR). Sixty patients were registered, and the DCR was 38.3% with a median progression-free survival of 2.5 months (95% confidence interval [CI] 1.9–3.7) and median overall survival of 10.0 months (95% CI 6.9–15.2). Common grade 3–4 adverse events were hand-foot skin reaction and hypertension (20.0% each). The results of administration of 120 mg regorafenib as the starting dose are consistent with reports from prior phase III trials, which used starting doses of 160 mg. This lower initiating dose of regorafenib may be beneficial to certain patient populations. This clinical trial was registered in the UMIN Clinical Trials Registry (UMIN-CTR number UMIN000018968, registration date: 10/09/2015).
Asynchrony in coral community structure contributes to reef-scale community stability
Authors: Srednick G. , Davis K. , Edmunds P. J. 
Published: February 2023

AbstractMany aspects of global ecosystem degradation are well known, but the ecological implications of variation in these effects over scales of kilometers and years have not been widely considered. On tropical coral reefs, kilometer-scale variation in environmental conditions promotes a spatial mosaic of coral communities in which spatial insurance effects could enhance community stability. To evaluate whether these effects are important on coral reefs, we explored variation over 2006–2019 in coral community structure and environmental conditions in Moorea, French Polynesia. We studied coral community structure at a single site with fringing, back reef, and fore reef habitats, and used this system to explore associations among community asynchrony, asynchrony of environmental conditions, and community stability. Coral community structure varied asynchronously among habitats, and variation among habitats in the daily range in seawater temperature suggested it could be a factor contributing to the variation in coral community structure. Wave forced seawater flow connected the habitats and facilitated larval exchange among them, but this effect differed in strength among years, and accentuated periodic connectivity among habitats at 1–7 year intervals. At this site, connected habitats harboring taxonomically similar coral assemblages and exhibiting asynchronous population dynamics can provide insurance against extirpation, and may promote community stability. If these effects apply at larger spatial scale, then among-habitat community asynchrony is likely to play an important role in determining reef-wide coral community resilience.
Assessing the reproducibility and up-scaling of the synthesis of Er,Yb-doped NaYF4-based upconverting nanoparticles and control of size, morphology, and optical properties
Authors: Andresen Elina , Islam Fahima , Prinz Carsten , Gehrmann Philipp , Licha Kai , Roik Janina , Recknagel Sebastian , Resch-Genger Ute 
Published: February 2023

AbstractLanthanide-based, spectrally shifting, and multi-color luminescent upconverting nanoparticles (UCNPs) have received much attention in the last decades because of their applicability as reporter for bioimaging, super-resolution microscopy, and sensing as well as barcoding and anti-counterfeiting tags. A prerequisite for the broad application of UCNPs in areas such as sensing and encoding are simple, robust, and easily upscalable synthesis protocols that yield large quantities of UCNPs with sizes of 20 nm or more with precisely controlled and tunable physicochemical properties from low-cost reagents with a high reproducibility. In this context, we studied the reproducibility, robustness, and upscalability of the synthesis of β-NaYF4:Yb, Er UCNPs via thermal decomposition. Reaction parameters included solvent, precursor chemical compositions, ratio, and concentration. The resulting UCNPs were then examined regarding their application-relevant physicochemical properties such as size, size distribution, morphology, crystal phase, chemical composition, and photoluminescence. Based on these screening studies, we propose a small volume and high-concentration synthesis approach that can provide UCNPs with different, yet controlled size, an excellent phase purity and tunable morphology in batch sizes of up to at least 5 g which are well suited for the fabrication of sensors, printable barcodes or authentication and recycling tags.
Maximizing the detection rate of hypoglycemia among preterm neonates admitted in Neonatal intensive care unit in Ethiopia, 2021
Authors: Chanie Ermias Sisay , Shiferaw Sahlu Mitku , Feleke Dejen Getaneh , Bantie Berihun , Moges Natnael , Tasew Sheganew Feten , Alemayehu Tikuneh Yetneberk , Teshome Assefa Agegnehu , Yirga Gebrie Kassaw , Berhan Ayenew , Amare Abraham Tsedalu , Libanos Mebratu , Emrie Wondosen Addis , Chanie Sewnet Sisay 
Published: February 2023

AbstractThe burden of hypoglycemia is high in resource limited countries, such as Ethiopia. However, there are no sufficient studies conducted in Ethiopia in general and in the study setting in particular in the previous era. Hence, this study aims to assess the proportion of hypoglycemia and associated factors among preterm neonates admitted to the neonatal intensive care unit at Debre Tabor Comprehensive Specialized Hospital, Ethiopia, in 2021. A hospital-based cross-sectional study was conducted from October 1 to December 30, 2021, at Debre Tabor Comprehensive Specialized Hospital in the neonatal intensive care unit ward. The data was entered in Epi-info 7 and exported to STATA version 14. A binary and multivariable logistic regression was computed at 95% confidence interval (CI). During bivariable analysis, variables having a p-value of less than 0.25 were chosen for multivariable logistic regression analysis, and variables having a p-value of less than 0.05 in multivariable analysis, were significant associations with the dependent variable. The study included 267 preterm neonates, and 23.59% (95% CI 18.9–29.1) were develop hypoglycemia. Moreover, 49 (18.35%) preterm neonates died during the study period. In this study, preterm neonates with hypothermia [Adjusted Odds Ratio (AOR = 4.5; 95 CI 3.4, 7.2)], birth asphyxia (AOR = 5.1; 95 CI 3.9, 27.1), seizure (AOR = 4.7; 95 CI 2.8, 17.8), and also preterm neonates born from diabetic mothers (AOR = 6.7; 95 CI 3.3, 27.2) were significantly associated with the occurrence of hypoglycemia in the neonatal intensive care. The proportion of hypoglycemia and associated factors among preterm neonates admitted to the neonatal intensive care unit at Debre Tabor Comprehensive Specialized Hospital was found to be high. The associated factors for the occurrence of hypoglycemia were discovered to be neonates with hypothermia, birth asphyxia, seizure, and neonates born with a diabetes mother. Thus, recognizing and treating the above associated factors is essential to preventing, and controlling hypoglycemia.
Estimation of gait events and kinetic waveforms with wearable sensors and machine learning when running in an unconstrained environment
Authors: Donahue Seth R. , Hahn Michael E. 
Published: February 2023

AbstractWearable sensors and machine learning algorithms are becoming a viable alternative for biomechanical analysis outside of the laboratory. The purpose of this work was to estimate gait events from inertial measurement units (IMUs) and utilize machine learning for the estimation of ground reaction force (GRF) waveforms. Sixteen healthy runners were recruited for this study, with varied running experience. Force sensing insoles were used to measure normal foot-shoe forces, providing a proxy for vertical GRF and a standard for the identification of gait events. Three IMUs were mounted on each participant, two bilaterally on the dorsal aspect of each foot and one clipped to the back of each participant’s waistband, approximating their sacrum. Participants also wore a GPS watch to record elevation and velocity. A Bidirectional Long Short Term Memory Network (BD-LSTM) was used to estimate GRF waveforms from inertial waveforms. Gait event estimation from both IMU data and machine learning algorithms led to accurate estimations of contact time. The GRF magnitudes were generally underestimated by the machine learning algorithm when presented with data from a novel participant, especially at faster running speeds. This work demonstrated that estimation of GRF waveforms is feasible across a range of running velocities and at different grades in an uncontrolled environment.
Alternative splicing of the SUMO1/2/3 transcripts affects cellular SUMOylation and produces functionally distinct SUMO protein isoforms
Authors: Acuña Myriah L. , García-Morin Andrea , Orozco-Sepúlveda Rebeca , Ontiveros Carlos , Flores Alejandra , Diaz Arely V. , Gutiérrez-Zubiate Isabel , Patil Abhijeet R. , Alvarado Luis A. , Roy Sourav , Russell William K. , Rosas-Acosta Germán 
Published: February 2023

AbstractSubstantial increases in the conjugation of the main human SUMO paralogs, SUMO1, SUMO2, and SUMO3, are observed upon exposure to different cellular stressors, and such increases are considered important to facilitate cell survival to stress. Despite their critical cellular role, little is known about how the levels of the SUMO modifiers are regulated in the cell, particularly as it relates to the changes observed upon stress. Here we characterize the contribution of alternative splicing towards regulating the expression of the main human SUMO paralogs under normalcy and three different stress conditions, heat-shock, cold-shock, and Influenza A Virus infection. Our data reveal that the normally spliced transcript variants are the predominant mature mRNAs produced from the SUMO genes and that the transcript coding for SUMO2 is by far the most abundant of all. We also provide evidence that alternatively spliced transcripts coding for protein isoforms of the prototypical SUMO proteins, which we refer to as the SUMO alphas, are also produced, and that their abundance and nuclear export are affected by stress in a stress- and cell-specific manner. Additionally, we provide evidence that the SUMO alphas are actively synthesized in the cell as their coding mRNAs are found associated with translating ribosomes. Finally, we provide evidence that the SUMO alphas are functionally different from their prototypical counterparts, with SUMO1α and SUMO2α being non-conjugatable to protein targets, SUMO3α being conjugatable but targeting a seemingly different subset of protein from those targeted by SUMO3, and all three SUMO alphas displaying different cellular distributions from those of the prototypical SUMOs. Thus, alternative splicing appears to be an important contributor to the regulation of the expression of the SUMO proteins and the cellular functions of the SUMOylation system.
Functional outcome after pediatric cerebral cavernous malformation surgery
Authors: Rauschenbach Laurèl , Santos Alejandro N. , Dinger Thiemo F. , Darkwah Oppong Marvin , Li Yan , Tippelt Stephan , Dohna-Schwake Christian , Schmidt Börge , Jabbarli Ramazan , Wrede Karsten H. , Sure Ulrich , Dammann Philipp 
Published: February 2023

AbstractThe purpose of this study was to investigate the functional outcome following surgical resection of cerebral cavernous malformations (CCM) in pediatric patients. We screened our institutional database of CCM patients treated between 2003 and 2021. Inclusion regarded individuals younger or equal than 18 years of age with complete clinical baseline characteristics, magnetic resonance imaging dataset, and postoperative follow-up time of at least three months. Functional outcome was quantified using the modified Rankin Scale (mRS) score and assessed at admission, discharge, and last follow-up examination. The primary endpoint was the postoperative functional outcome. As a secondary endpoint, predictors of postoperative functional deterioration were assessed. A total of 49 pediatric patients with a mean age of 11.3 ± 5.7 years were included for subsequent analyses. Twenty individuals (40.8%) were female. Complete resection of the lesion was achieved in 44 patients (89.8%), and two patients with incomplete resection were referred for successive remnant removal. The mean follow-up time after surgery was 44 months (IQR: 13 – 131). The mean mRS score was 1.6 on admission, 1.7 at discharge, and 0.9 at the latest follow-up. Logistic regression analysis adjusted to age and sex identified brainstem localization (aOR = 53.45 [95%CI = 2.26 − 1261.81], p = .014) as a predictor of postoperative deterioration. This study indicates that CCM removal in children can be regarded as safe and favorable for the majority of patients, depending on lesion localization. Brainstem localization implies a high risk of postoperative morbidity and indication for surgery should be balanced carefully. Minor evidence indicates that second-look surgery for CCM remnants might be safe and favorable.
Semi-empirical infrared spectra simulation of pyrene-like molecules insight for simple analysis of functionalization graphene quantum dots
Authors: Setianto Setianto , Panatarani Camellia , Singh Deoraj , Joni I Made 
Published: February 2023

AbstractThe Infrared (IR) spectra usually assume the samples are 3D materials. Thus, it is difficult to identify functional groups in 2D materials at the edge and the center of the 2D surface. Therefore, it is crucial to introduce analysis methods that enable the investigation of 2D carbon materials such as graphene and its derivatives using IR spectra. This study calculates the infrared spectra of pyrene-like molecules as an insight for a simple analysis of graphene quantum dots using a semi-empirical method. These IR spectra were correlated to the electronic transition and charge distribution associated with functional groups. The IR spectra analysis focuses on comparing the pristine and functionalized molecule at the wavenumber 1400–2000 cm−1, especially to identify the C=C stretching mode and 3000–3500 cm−1 for C–H and OH stretching. Moreover, the determination of excitation spectra was carried out to analyze the electronic transition of the molecules in the ultraviolet–visible region (200–900 nm) calculated using ZINDO method. The investigation of the pyrene-like GQD permitted the identification of the edge and center surface functionalization in 2D carbon materials.
Sizing down and functionalizing polylactide (PLA) resin for synthesis of PLA-based polyurethanes for use in biomedical applications
Authors: Nim Bunthoeun , Rahayu Sosna Sri , Thananukul Kamonchanok , Eang Chorney , Opaprakasit Mantana , Petchsuk Atitsa , Kaewsaneha Chariya , Polpanich Duangporn , Opaprakasit Pakorn 
Published: February 2023

AbstractAlcoholysis is a promising approach for upcycling postconsumer polylactide (PLA) products into valuable constituents. In addition, an alcohol-acidolysis of PLA by multifunctional 2,2-bis(hydroxymethyl)propionic acid (DMPA) produces lactate oligomers with hydroxyl and carboxylic acid terminals. In this work, a process for sizing down commercial PLA resin to optimum medium-sized lactate oligomers is developed at a lower cost than a bottom-up synthesis from its monomer. The microwave-assisted reaction is conveniently conducted at 220–240 °C and pressure lower than 100 psi. The PLA resin was completely converted via alcohol-acidolysis reaction, with a product purification yield as high as 93%. The resulting products are characterized by FTIR, 2D-NMR, 1H-NMR, GPC, DSC, and XRD spectroscopy. The effects of PLA: DMPA feed ratios and the incorporation of 1,4-butanediol (BDO) on the structures, properties, and particle formability of the alcohol-acidolyzed products are examined. The products from a ratio of 12:1, which possessed optimum size and structures, are used to synthesize PLA-based polyurethane (PUD) by reacting with 1,6-diisocyanatohexane (HDI). The resulting PUD is employed in encapsulating lavender essential oil (LO). Without using any surfactant, stable LO-loaded nanoparticles are prepared due to the copolymer’s self-stabilizability from its carboxylate groups. The effect of the polymer: LO feed ratio (1.25–3.75: 1) on the physicochemical properties of the resulting nanoparticles, e.g., colloidal stability (zeta potential > -60 mV), hydrodynamic size (300–500 nm), encapsulation efficiency (80–88%), and in vitro release, are investigated. The LO-loaded nanoparticles show non-toxicity to fibroblast cells, with an IC50 value higher than 2000 µg/mL. The products from this process have high potential as drug encapsulation templates in biomedical applications.
Long non-coding RNA KCNQ1OT1 alleviates postmenopausal osteoporosis by modulating miR-421-3p/mTOR axis
Authors: Wang Ziyu , Zhang Hengshuo , Li Qinghui , Zhang Lu , Chen Lu , Wang Hongliang , Chen Yunzhen 
Published: February 2023

AbstractThe prevention and treatment of postmenopausal osteoporosis (PMOP) is a significant public health issue, and non-coding RNAs are of vital importance in this process. In this study, we find that the long non-coding RNA potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (lncRNA KCNQ1OT1) can alleviate the ovariectomy-induced (OVX) PMOP in vivo. We determined that over-expression of KCNQ1OT1 could enhance functions of MC3T3-E1 cells, whereas an opposite trend was observed when KCNQ1OT1 was knocked down. Subsequently, miR-421-3p targeting KCNQ1OT1 was detected through a database search, and RNA fluorescent in situ hybridization, RNA immunoprecipitation, dual luciferase reporter assays all verified this relationship. Notably, KCNQ1OT1 stifled the miR-421-3p expression. The inhibition of proliferation, migration, and osteogenic differentiation caused by KCNQ1OT1 knock-down were reversed by an miR-421-3p inhibitor, further confirming the above findings. We verified that miR-421-3p specifically targeted the mammalian target of rapamycin (mTOR), and miR-421-3p inhibitor could reverse the negative effects of small interfering RNA of mTOR (si-mTOR) on MC3T3-E1 cells. Finally, osteoblasts isolated and cultured from OVX mice model and control mice also confirmed the observed trend. In combination, results mentioned above reveal that KCNQ1OT1 regulates MC3T3-E1 cell functions by regulating the miR-421-3p/mTOR axis.
An efficient and highly accurate singularity extraction method for the evaluation of transient potentials of stratified media
Authors: Sahafi Seyyed Abbas , Ghaffari‐Miab Mohsen , Souri Saeed 
Published: February 2023

AbstractAn efficient and highly accurate method for extracting the singularity of scalar potential time‐domain Green's function (TDGF) of layered media is presented. The proposed method is based on the Taylor series expansion and is exploited in the finite‐difference (FD) technique. The presented method is accurate for the singularity behavior of the potential near the source. Also, the effect of singularity extraction box size on the calculation error of Green's functions is explained. Numerical results demonstrating the accuracy of the proposed singularity extraction method for calculating the TDGF of a PEC‐backed dielectric slab are presented. It is shown that the accuracy of the evaluated TDGF is improved by an order of magnitude using the proposed singularity extraction technique. Also, the effect of changing the spatial and temporal steps of the FD scheme on the calculation error is studied.
Solar‐wind hybrid energy system to supply electricity for offshore oil and gas platforms in the Caspian Sea: A case study
Authors: Zereshkian Sajjad , Mansoury Dariush 
Published: February 2023

AbstractIn this research, the environmental feasibility of a hybrid renewable source of wind‐solar energy has been assessed and the amount of this energy on offshore oil and gas platforms has been estimated in three basins of the Caspian Sea. Extractable wind‐solar energy around the Caspian oil and gas platforms was investigated using the Medium‐range Weather Forecast database by applying a resolution of 0.125° and a time step of 6 h for 10 years (2005–2014). The findings showed that the average wind energy in the northern, middle, and southern basins at the height of 10 m are 1.10, 0.89, and 0.43, respectively. Centralnoy field with an average energy of 2.398 MWh/m2.year is the most suitable oil and gas offshore platform for a hybrid application of wind‐solar energy. Inkie Moor field has the lowest amount of hybrid energy (1.432 MWh/m2.year) in the Caspian Sea.
Genetische Grundlagen, Beratung und Testung bei Patienten mit pulmonalarterieller Hypertonie
Authors: Haas Simon , Shaukat Memoona , Grünig Ekkehard , Eichstaedt Christina A. 
Published: February 2023

ZusammenfassungDie pulmonalarterielle Hypertonie (PAH) ist eine seltene und schwere Erkrankung, die durch einen erhöhten pulmonalarteriellen Mitteldruck und einen erhöhten pulmonalvaskulären Widerstand
charakterisiert ist. Sie hat in vielen Fällen eine genetische Ursache, so findet man bei 85% der hereditären und bei ca. 15% der idiopathischen Fälle pathogene Varianten in PAH-spezifischen
Genen. Am häufigsten ist das Gen des Bone Morphogenetic Protein Receptor Type 2 (BMPR2) betroffen. Es wurden jedoch in den letzten Jahren 17 weitere Gene größtenteils aus dem
Signalweg des BMPR2-Gens entdeckt, die bei der diagnostischen Abklärung mit untersucht werden sollten. Dieser Artikel beschäftigt sich mit den molekulargenetischen Grundlagen der
Erkrankung, dem Stellenwert der genetischen Beratung und Testung in den neuen Leitlinien sowie mit den wichtigsten Genen und den Verfahren, mit welchen man diese auf pathogene Varianten
untersuchen kann. Die genetische Untersuchung kann einen Beitrag zur korrekten Diagnosestellung und zur Prognoseverbesserung der Patienten leisten und sollte auch gesunden
Familienmitgliedern angeboten werden.
Semillas de la rebelión: Revolutionary postmemory, hip-hop, and Chilean exile
Authors: Gavin-Bravo Camila 
Published: February 2023

AbstractThis article uses interviews and cultural analysis to examine how hip-hop is a site for the reproduction of the second-generation Chilean exile hip-hop group Rebel Diaz's revolutionary postmemory of Allende-era politics in Chile. Revolutionary postmemory posits that Rebel Diaz, and second-generation Chilean exiles more generally, inherit not only the trauma and pain of the Pinochet regime but also the radical politics and hope of the Allende era.