bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical and physical modeling of breast cancer based on image fusion and artificial intelligence
Authors: Dołęga-Kozierowski Bartosz , Kasprzak Piotr , Lis Michał , Szynglarewicz Bartłomiej , Matkowski Rafał , Sawicki Marek , Dymek Mateusz , Szumiejko Adrianna , Carmo Gustavo , Kwiatkowski Artur , Soliński Daniel Grzegorz , Ptak Mariusz 
Published: July 2023

AbstractPurposeThe key problem raised in the paper is the change in the position of the breast tumor due to magnetic resonance imaging examinations in the abdominal position relative to the supine position during the surgical procedure. Changing the position of the patient leads to significant deformation of the breast, which leads to the inability to indicate the location of the neoplastic lesion correctly.MethodsThis study outlines a methodological process for treating cancer patients. Pre-qualification assessments are conducted for magnetic resonance imaging (MRI), and 3D scans are taken in three positions: supine with arms raised, supine surgical position (SS), and standing. MRI and standard ultrasonography (USG) imaging are performed, and breast and cancer tissue are segmented from the MRI images. Finite element analysis is used to simulate tissue behavior in different positions, and an artificial neural network is trained to predict tumor dislocation. Based on the model, a 3D-printed breast with a highlighted tumor is manufactured. This computer-aided analysis is used to create a detailed surgical plan, and lumpectomy surgery is performed in the SS. In addition, the geometry of the tumor is presented to the medical staff as a 3D-printed element.ResultsBy utilizing a comprehensive range of techniques, including pre-qualification assessment, 3D scanning, MRI and USG imaging, segmentation of breast and cancer tissue, model analysis, image fusion, finite element analysis, artificial neural network training, and additive manufacturing, a detailed surgical plan can be created for performing lumpectomy surgery in the supine surgical position.ConclusionThe new approach developed for the pre-operative assessment and surgical planning of breast cancer patients has demonstrated significant potential for improving the accuracy and efficacy of surgical procedures. This procedure may also help the pathomorphological justification. Moreover, transparent 3D-printed breast models can benefit breast cancer operation assistance. The physical and computational models can help surgeons visualize the breast and the tumor more accurately and detailedly, allowing them to plan the surgery with greater precision and accuracy.
Targeting miRNA and using miRNA as potential therapeutic options to bypass resistance in pancreatic ductal adenocarcinoma
Authors: Vahabi Mahrou , Dehni Bilal , Antomás Inés , Giovannetti Elisa , Peters Godefridus J. 
Published: July 2023

AbstractPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with poor prognosis due to early metastasis, low diagnostic rates at early stages, and resistance to current therapeutic regimens. Despite numerous studies and clinical trials, the mortality rate for PDAC has shown limited improvement. Therefore, there is a pressing need to attain. a more comprehensive molecular characterization to identify biomarkers enabling early detection and evaluation of treatment response. MicroRNA (miRNAs) are critical regulators of gene expression on the post-transcriptional level, and seem particularly interesting as biomarkers due to their relative stability, and the ability to detect them in fixed tissue specimens and biofluids. Deregulation of miRNAs is common and affects several hallmarks of cancer and contribute to the oncogenesis and metastasis of PDAC. Unique combinations of upregulated oncogenic miRNAs (oncomiRs) and downregulated tumor suppressor miRNAs (TsmiRs), promote metastasis, characterize the tumor and interfere with chemosensitivity of PDAC cells. Here, we review several oncomiRs and TsmiRs involved in chemoresistance to gemcitabine and FOLFIRINOX in PDAC and highlighted successful/effective miRNA-based therapy approaches in vivo. Integrating miRNAs in PDAC treatment represents a promising therapeutic avenue that can be used as guidance for personalized medicine for PDAC patients.
An investigation on space debris of unknown origin using proper elements and neural networks
Authors: Wu Di , Rosengren Aaron J. 
Published: July 2023

AbstractProper elements represent a dynamical fingerprint of an object’s inherent state and have been used by small-body taxonomists in characterizing asteroid families. Being linked to the underlying dynamical structure of orbits, Celletti, Pucacco, and Vartolomei have recently adopted these innate orbital parameters for the association of debris from breakup or collision into its parent satellite. Building from this rich astronomical heritage and recent foundations, we introduce an unsupervised learning method—density-based spatial clustering of applications with noise (DBSCAN)—to determine clusters of orbital debris in the space of proper elements. Data is taken from the space-object catalog of trackable Earth-orbiting objects in the form of two-line element sets. Proper elements for debris fragments in low-Earth orbit are computed using an ad hoc numerical scheme, akin to the state-of-the-art Fourier-series-based synthetic method for the asteroid domain. Given the heuristic nature of classical DBSCAN, we investigate the use of neural networks, trained on known families, to augment DBSCAN into a classification problem and apply it to analyst objects of unknown origin.
Factor Structure and Psychometric Properties of the Spence Children’s Anxiety Scale: A 25-Year Systematic Review
Authors: Galán-Luque Teresa , Serrano-Ortiz Marina , Orgilés Mireia 
Published: July 2023

AbstractThe Spence Children’s Anxiety Scale (SCAS) is one of the most used instruments to assess anxiety symptoms in children and adolescents. Extensive research has been conducted to examine its psychometric properties and to develop other versions of the scale. The objective of this study was to examine the psychometric properties and factorial structure of the SCAS across different versions and populations. This systematic review followed PRISMA guidelines and was registered. APA PsycINFO, Web of Science (Core Collection) and MEDLINE (PubMed) were searched. Fifty-two studies were included in this systematic review. They examined the factor structure, convergent and divergent validity, and internal consistency of the scale. The most supported model was the original six-factor model, followed by the higher order six-factor model for the long version of the SCAS. Studies provided evidence of convergent validity and internal consistency. It is concluded that the SCAS is a valid and reliable instrument for assessing anxiety symptoms in children and adolescents, with a six-factor model structure well supported in most populations. Further research on the psychometric properties and factor structure of other versions of the scale and its application to clinical populations is warranted.
Outcome Expectations in Psychotherapy: Validation of the Therapy Single Category Implicit Association Test (Therapy SC-IAT)
Authors: Seewald Anna , Teige-Mocigemba Sarah , Rief Winfried 
Published: July 2023

Abstract
Background
Former studies demonstrated that negative outcome expectations (OE) toward psychotherapy predict unfavorable psychotherapy outcomes. Critically, the measurement of OE is limited to direct measures that could be subject to self-presentational distortions. This study aimed to validate an online single category implicit association test (SC-IAT) to measure OE toward psychotherapy indirectly.

Methods
We conducted three direct measures of OE, the Therapy SC-IAT, and a (control) Flower SC-IAT in a large sample (N = 705).

Results
The Therapy SC-IAT correlated with most direct measures of OE (convergent validity) but not with measures of flower associations (discriminant validity). In exploratory analyses, we found that direct and indirect measurements of OE were related to prior experiences with psychotherapy.

Conclusion
We discuss ways to improve the indirect-direct correlations and suggest that our newly developed indirect measure could complement the assessment of expectations in research and clinical practice.
The implication of ciliary signaling pathways for epithelial–mesenchymal transition
Authors: Zhong Bang-Hua , Dong Ming 
Published: July 2023

AbstractEpithelial-to-mesenchymal transition (EMT), which plays an essential role in development, tissue repair and fibrosis, and cancer progression, is a reversible cellular program that converts epithelial cells to mesenchymal cell states characterized by motility-invasive properties. The mostly signaling pathways that initiated and controlled the EMT program are regulated by a solitary, non-motile organelle named primary cilium. Acting as a signaling nexus, primary cilium dynamically concentrates signaling molecules to respond to extracellular cues. Recent research has provided direct evidence of connection between EMT and primary ciliogenesis in multiple contexts, but the mechanistic understanding of this relationship is complicated and still undergoing. In this review, we describe the current knowledge about the ciliary signaling pathways involved in EMT and list the direct evidence that shows the link between them, trying to figure out the intricate relationship between EMT and primary ciliogenesis, which may aid the future development of primary cilium as a novel therapeutic approach targeted to EMT.
Involvement of indoleamine 2, 3-dioxygenase (IDO) and brain-derived neurotrophic factor (BDNF) in the neuroprotective mechanisms of ferulic acid against depressive-like behaviour
Authors: Mallik Sanchari Basu , Mudgal Jayesh , Kinra Manas , Hall Susan , Grant Gary D. , Anoopkumar-Dukie Shailendra , Nampoothiri Madhavan , Zhang Yuqing , Arora Devinder 
Published: July 2023

AbstractObjective: Ferulic acid (FA) is a common food ingredient that is abundantly present in various routinely consumed food and beverages. Like many cinnamic acid derivatives, FA produces wide-ranging effects in a dose-dependent manner and various studies link FA consumption with reduced risk of depressive disorders. The aim of this study was to exploit the neuroprotective mechanisms of FA including indoleamine 2,3-dioxygenase (IDO), brain-derived neurotrophic factor (BDNF), and other pro-inflammatory cytokines by employing lipopolysaccharide (LPS)-induced depressive-like behaviour model. Methods: C57BL/6J male mice were divided into 4 groups consisting of saline (SAL), LPS, FA and Imipramine (IMI). Animals were pretreated orally with FA (10 mg/kg) and IMI (10 mg/kg) for 21 days once daily and all groups except SAL were challenged with LPS (0.83 mg/kg) intraperitoneally on day 21. Results: LPS administration produced a biphasic change in the behaviour of the animals where the animals lost a significant weight and express high immobility time at 24 h. Proinflammatory cytokines including, TNF-α, IL-6, IL-1β, and IFN-γ were significantly increased along with increased lipid peroxidation and reduced BDNF. Furthermore, the increased kynurenine to tryptophan ratio was indicative of elevated IDO activity. Conclusion: The results of this study emphasise that low dose of FA is effective in attenuating depressive-like behaviour by modulating IDO, BDNF and reducing neuroinflammation.
Envisioning the future of virtual production in filmmaking: A remote co-design study
Authors: Bodini Aimone , Manohar Arthi , Colecchia Federico , Harrison David , Garaj Vanja 
Published: July 2023

AbstractVirtual Production is a new process in the audiovisual industry, taking advantage of emerging technologies and attracting a significant degree of interest in academic and industrial research. This article documents a research process focusing on co-design of innovative solutions for Virtual Production relying on immersive technologies. Two remote collaborative workshops were organized involving audiovisual professionals covering different roles in different phases of the making process of audiovisual production. A range of innovative design concepts was generated as part of the research following group-based iterative discussion and evaluation. The study has contributed a set of innovative design solutions in relation to applications of immersive technologies in the audiovisual industry. The authors argue that the methods adopted have the potential to serve as a blueprint for design and implementation of future remote collaborative co-design processes in relation to audiovisual studies and, more generally, across disciplinary boundaries.
Mathematics Skills in Epilepsy: A Systematic Review and Meta-Analysis
Authors: Poole Belinda J. , Phillips Natalie L. , Killer Brittany L. , Gilmore Camilla , Lah Suncica 
Published: July 2023

AbstractMathematics incorporates a broad range of skills, which includes basic early numeracy skills, such as subitizing and basic counting to more advanced secondary skills including mathematics calculation and reasoning. The aim of this review was to undertake a detailed investigation of the severity and pattern of early numeracy and secondary mathematics skills in people with epilepsy. Searches were guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Twenty adult studies and 67 child studies were included in this review. Overall, meta-analyses revealed significant moderate impairments across all mathematics outcomes in both adults (g= -0.676), and children (g= -0.593) with epilepsy. Deficits were also observed for specific mathematics outcomes. For adults, impairments were found for mathematics reasoning (g= -0.736). However, two studies found that mathematics calculation was not significantly impaired, and an insufficient number of studies examined early numeracy skills in adults. In children with epilepsy, significant impairments were observed for each mathematics outcome: early numeracy (g= -0.383), calculation (g= -0.762), and reasoning (g= -0.572). The gravity of impairments also differed according to the site of seizure focus for children and adults, suggesting that mathematics outcomes were differentially vulnerable to the location of seizure focus.
Benevolent and Hostile Sexism in Endorsement of Heterosexist Marriage Traditions Among Adolescents and Adults
Authors: Brett Rose , Hopkins-Doyle Aife , Robnett Rachael , Watson Nila , Tenenbaum Harriet R. 
Published: July 2023

AbstractWithin most western countries, gendered proposal, surname, and wedding traditions remain widely endorsed. A previous study indicated that endorsement of proposal and surname traditions is associated with higher levels of benevolent sexism (BS) in university students in the USA. Three studies (N = 367) extended research to adolescents (dating age) and 30-year-olds (typical first-time marriage age). For the first time, these studies examined gendered wedding traditions (e.g., father walking a bride down the aisle). Different combinations of ambivalent sexism predicted participants’ opinions about surname change after marriage and the choice of children’s surnames. In younger adolescents (11–18 years; 56 boys, 88 girls, 68.1% White), hostile sexism (HS) predicted endorsement of surname change, whereas benevolent sexism predicted endorsement in 16- to 18-year-olds (58 boys, 84 girls, 76.8% White) and 30-year-olds (37 men, 44 women, 74.1% White). In adolescent samples, both BS and HS predicted endorsement of patronymic traditions for children, whereas only BS did in the adult sample. The findings suggest that different types of sexism predict traditional beliefs in specific age groups.
Influence of Local Electropolishing Conditions on Ferritic–Pearlitic Steel on X-Ray Diffraction Residual Stress Profiling
Authors: Holmberg Jonas , Berglund Johan , Stormvinter Albin , Andersson Pär , Lundin Per 
Published: July 2023

AbstractLayer removal with electropolishing is a well-established method when measuring residual stress profiles with lab-XRD. This is done to measure the depth impact from processes such as shot peening, heat treatment, or machining. Electropolishing is used to minimize the influence on the inherent residual stresses of the material during layer removal, performed successively in incremental steps to specific depths followed by measurement. Great control of the material removal is critical for the measured stresses at each depth. Therefore, the selection of size of the measurement spot and electropolishing parameters is essential. The main objective in this work is to investigate how different electrolytes and electropolishing equipment affect the resulting surface roughness, geometry, microstructure, and consequently the measured residual stress. A second objective has been to establish a methodology of assessing the acquired electropolished depth. The aim has been to get a better understanding of the influence of the layer removal method on the accuracy of the acquired depth. Evaluation has been done by electropolishing one ground and one shot peened sample of a low-alloy carbon steel, grade 1.1730, with different methods. The results showed a difference in stresses depending on the electrolyte used where the perchloric acid had better ability to retain the stresses compared to the saturated salt. Electropolishing with saturated salt is fast and results in evenly distributed material removal but has high surface roughness, which is due to a difference in electropolishing of the two phases, ferrite, and pearlite. Perchloric acid electropolishing is slower but generates a smooth surface as both ferrite and pearlite have the same material removal rates but may cause an increased material removal for the center of the electropolished area. In this work, it is suggested to use perchloric acid electropolishing for the final layer removal step.
Poliklinische plicatieplastiek bij kromstand van de penis
Authors: Ćosović Admira , Essink Judith G. J. , Beets-van Essen W. K. Miranda , Santerse A. Boudewijn 
Published: July 2023

SamenvattingEen kromstand van de penis, de ziekte van Peyronie, kan leiden tot seksuele problemen en dyspareunie bij de partner, maar ook tot een verminderd zelfbeeld en onzekerheid. Behandeling is geïndiceerd als coïtus moeilijk of pijnlijk is. De meest succesvolle behandeling om de stand te corrigeren is chirurgisch. De klassieke operatie omvat circumcisie en deglovement en vindt plaats op de operatiekamer. Wij ontwikkelden een minimaal invasieve voorhuidsparende plicatieplastiek die poliklinisch onder lokale anesthesie wordt uitgevoerd en evalueerden de resultaten van de 21 plicatieplastieken die werden uitgevoerd tussen oktober 2019 en december 2021. Uit de resultaten blijkt dat deze plastiek veilig, succesvol en patiëntvriendelijk onder lokaalanesthesie kan worden uitgevoerd. De tevredenheid van de patiënten over de ingreep is groot en het functionele resultaat van de ingreep is goed. Met onze plastiek kunnen kosten en kostbare operatietijd worden bespaard.
Pairing Sturgeon with Champagne: Towards a Due Cause Exception in the Law of Geographical Indications
Authors: Dijkman Léon 
Published: July 2023

AbstractIt is commonly lamented that geographical indications (GIs) receive extravagant protection under European Union (EU) law. Yet due to the special nature of GIs it can be hard to conceptualize sensible limitations to protection and so far the question where such limits (if any) should lie has received little attention in scholarship. This article advances the argument for a “due cause exception” in the law of GIs. It examines two categories of use that may legitimately benefit from such an exception: descriptive uses and uses that fall within the scope of freedom of expression provisions, for instance use of GIs as part of artistic works or parodies. The article argues that these and other uses should be evaluated according to a two-pronged test to establish whether they are objectively justified and in accordance with honest practices. Lastly, it argues that even if no express due cause exception is or becomes part of the applicable GI regulations, guidance by the Court of Justice of the European Union on the interpretation of EU law in light of EU primary law mandates observance of countervailing fundamental rights also within the contours of the current regulations. Because the categories of use outlined in this article fall within the scope of the freedom to conduct a business and the freedom of expression and the arts, at least some allowance must be made for these uses when interpreting and applying the protection due to GIs.
Security Energy Efficiency Analysis of CR-NOMA Enabled IoT Systems for Edge-cloud Environment
Authors: She Rui , Sun Mengyu 
Published: July 2023

AbstractWith the development of the Internet of Things (IoT), more and more devices are connected in edge-cloud environment, and spectrum scarcity has become a major bottleneck for the employment of IoT devices in the end side of cloud computing. In addition, due to the broadcast nature of RF link, the potential eavesdropper may be presented in the wireless environment. To improve spectrum efficiency (SE) and ensure safe transmission of the users, in this paper, the two-way relay cooperative Cognitive Radio Non-Orthogonal Multiple Access (CR-NOMA) with massive multiple-in multiple-out (MIMO) is proposed. Our objective is to maximize the security energy efficiency (SEE) of the cognitive system subject to the quality of service (QoS) of users. Specifically, the multi-objective optimization problem is decomposed into three subproblems, i.e., the optimization of transmit power, power allocation, and antenna selection, respectively. The Lagrange dual algorithm based on the first-order Taylor series expansion function is proposed to solve the non-convex problem. Moreover, a novel orthogonal antenna selection algorithm is proposed to decrease the cost of radio frequency chains and limit the interference to the primary user. The simulation results show that the proposed scheme has significant performance gain on SEE. It can effectively increase the number of access for cloud computing edge IoT users. In addition, due to the impact of correlation between the antennas, as the number of relay antennas increases, the SEE converges to a specific value, which exists the optimal number of antenna.
Recurrent Benign Lymphocytic Meningitis Due to HSV-2: A Case Report
Authors: Ahmad Sirine , Alsaeed Mohammed 
Published: July 2023

AbstractRecurrent benign lymphocytic meningitis (RBLM) is an uncommon form of aseptic meningitis characterized by the recurrence of meningeal symptoms followed by spontaneous recovery. Historically, RBLM has been attributed to herpes simplex virus (HSV) type 2 infection. Diagnosis is traditionally confirmed by PCR of viral DNA isolated from the CSF. Although the disease course is usually benign, antiviral therapy may benefit some patients. Here, we report the case of a young woman diagnosed with four episodes of aseptic meningitis within 10 years. The presence of HSV type 2 in the CSF was confirmed using PCR in three of the episodes. After the resolution of acute attacks, the patient was symptom-free with no neurological sequelae.