bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for neck pain in college students: a systematic review and meta-analysis
Authors: Gao Yifang , Chen Zhiming , Chen Shaoqing , Wang Shizhong , Lin Jianping 
Published: January 2023

Abstract
Background: During the COVID-19 epidemic, the prevalence of neck pain among college students has increased due to the shift from offline to online learning and increasing academic and employment pressures. Therefore, this systematic review aimed to identify the personal, occupational, and psychological factors associated with the development of neck pain to promote the development of preventive strategies and early intervention treatment.
Methods: Seven electronic databases were searched from inception to April 2022 for cross-sectional studies, cohort studies, case-control studies, and randomized controlled trials (RCT) on neck pain. The quality of the selected studies was assessed by American Agency for Healthcare Research and Quality (AHRQ) or the Newcastle-Ottawa scale (NOS). Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the effects of the included risk factors on neck pain.
Results: Twenty-six studies were included, including 16,826 participants, and a total of 30 potentially associated risk factors were identified, with 20 factors only listed as risk factors in one or two studies. Ultimately, 10 risk factors were included in the meta-analysis, and all results were statistically significant (P<0.05). The factors supported by strong evidence mainly include the improper use of the pillow (OR=2.20, 95% CI: 1.39 to 3.48), lack of exercise (OR=1.88, 95% CI: 1.53 to 2.30), improper sitting posture (OR=1.97, 95% CI: 1.39 to 2.78), and history of neck and shoulder trauma (OR=2.32, 95% CI: 1.79 to 3.01), senior grade (OR=2.86, 95% CI: 2.07 to 3.95), staying up late (OR=1.80, 95% CI: 1.35 to 2.41), and long-time electronic product usage daily (OR=1.45, 95% CI: 1.27 to 1.65), long-time to bow head (OR=2.04, 95% CI: 1.58 to 2.64), emotional problems (OR=2.09; 95% CI: 1.66, 2.63). Risk factors supported by moderate evidence were high pressure (OR=1.91, 95% CI: 1.50 2.42).
Conclusion: Improper use of the pillow, lack of exercise, improper sitting posture, history of neck and shoulder trauma, senior grade, staying up late, long-term electronic product usage daily, long time to bow head, high pressure, and emotional problems affect neck pain in college students. More studies have been conducted to prove the risk and relevance of the remaining 20 factors.
Wax Metabolism is involved in Response to Alternate Freeze-thaw Stress to Regulate Shoot Shriveling
Authors: Gao Yanlong , Zhang Zhongxing , Wang Shuangcheng , Ma Naiying , Wang Yanxiu 
Published: January 2023

Abstract
Shoot shriveling is one of the main challenges for apple (Malus×domestica) growth and productivity. Cuticular wax plays a critical role in plant resistance. In this study, branches of 'Asi' and 'Miyazaki' with different overwintering characters were selected, and a series of physiological indicators were measured. The results showed that shoot shriveling rate of 'Miyazaki' was 2.31 times than 'Asi', the critical water content of 'Asi' was higher than 'Miyazaki'; In freeze-thaw alternate phase of 'Asi', the activities of starch phosphorylase (SP) and amylase (Amy) was 1.54 and 1.2 times that of 'Miyazaki', the relative conductivity (REC) and Proline (Pro) were 0.89 and 0.65 times that of 'Miyazaki'. The wax content of the two varieties in the freezing-thawing phase decreased to 41.84% and 60.63%, respectively, 'Asi' wax was tightly distributed and wax components was much diversify than 'Miyazaki'. The correlation analysis showed that the wax content was positively correlated with the water content and negatively correlated with shoot shriveling rate. Subsequently, eleven wax-related genes were selected for expression to verify their reliability. Under freeze-thaw stress, the expression of CER1 dramatically increased, and the expression of KCS1, CER3 and WIN1 increased firstly and then decreased with the elongation of stress time. Compared with the sensitive shriveling 'Miyazaki', the anti-sensitive shriveling 'Asi' strengthens its overwintering by containing higher water content, triggering the expression of CER1, CER3, WIN1 and other genes, enriching its waxy components, increasing the content of osmotic adjustment substances, and improving the water retention performance during the overwintering process.
Enhanced visible light photocatalytic degradation of methylene blue dye using efficient Mg/S codoped TiO2 nanoparticles
Authors: Kunnamareddy Mehala , Natchimuthu Karmegam , Tangavelu Kavitha , Palanisamy Senthilkumar , Diravidamani Barathi , Shkir Mohd , Hamed Algarni , Rajendran Ranjith 
Published: January 2023

Abstract
Herein, the Mg-S codoped TiO2 nanoparticles (NPs) were synthesized by the sol-gel method, and their photocatalytic activity of MB (Methylene Blue) dye was examined under simulated visible light. The crystal structure, morphology analysis, optical properties, and photocatalytic performance of synthesized nanoparticles (NPs) were characterized by XRD, FTIR, SEM with EDS, TEM, UV-DRS, and UV-Vis spectroscopy. Results showed that Mg/S codoped TiO2 NPs had pure anatase structure with spherical morphology. The band gap energy Mg/S codoped TiO2 was decreased from 3.12 eV to 2.78 eV by adding the doping and codoping of Mg and S into TiO2 NPs. The Mg/S codoped TiO2 NPs showed excellent photocatalytic activity compared to that of pristine TiO2, Mg-TiO2, and S-TiO2 NPs. The maximum degradation efficiency of MB was achieved at 94.8% for Mg/S codoped TiO2 NPs. Meanwhile, the possible photocatalytic mechanism of Mg/S codoped TiO2 was discussed. The current investigation delivers a promising strategy to promote photocatalytic activity for the elimination of waterborne contaminants.
Walnut cultivation in Kashmir Valley, India: An economic &amp; profitability assessment
Authors: Lone Fayaz A. , Ganaie M. Imran , Ganaie Showkat A. , Bhat M. Shafi , Rather Javeed A. 
Published: January 2023

Abstract

Jammu and Kashmir is the largest producer of walnuts in India and it acts as an important source of livelihood for a large section of farmers. The present study aims to measure the profitability and economic efficiency of walnut orchards and subsequently explore constraints hindering walnut cultivation in the Valley of Kashmir, India. It relies on cross-sectional database collected from 240 walnut growers in the study area during the 2018-19 production period. Results reveal that walnut cultivation is highly labour-intensive as it incurs 80% of total production costs. The cost-benefit ratio of 1:5.35/ha indicates better economic prospects for the walnut industry in Kashmir Valley. The regression coefficients of production analysis and marginal value product and marginal factor cost (MVP/MFC) ratio indicate that there is ample scope for the expansion of walnut cultivation in the research area. However, walnut growers are confronted by several problems that more or less tend to be location specific. The study calls for policy intervention concerning better extension services, greater access to credit and farmer training programs to boost walnut production in the study region.
Cr oxide coated woodland camouflage textiles for protection of defense target signature in UV-Visible-IR spectrum opposing of hyperspectral and digital imaging
Authors: Hossain Md. Anowar 
Published: January 2023

Abstract
The chromatic intensity and thermal mechanism are vital segment for protection of military target in ultraviolet (UV)-visible (Vis)-infrared (IR) imaging. Defense operations need to confront with UV-Vis-IR imaging to distinguish/conceal the target from combat background (CB). The key purpose of this experimentation is to develop the imaging and optical intensity concepts of chromatic appearance for concealment, detection, recognition, and identification (CDRI) of Cr oxide coated target signature against hyperspectral and digital camera imaging in UV-Vis-IR optical signal. Chromatic intensity of Cr oxide formulated polyamide 6,6 (PA-6,6) fabric was examined by Vis-IR-hyperspectral imaging (HSI) in 400 nm, 500 nm, 600 nm, 700 nm, 1000 nm, 1300 nm, 1600 nm, 1900 nm, 2200 nm, 2500 nm. UV-Vis-IR-HSI has been experimented by international commission on illumination (CIE); red-green-blue standardized color scale for concealment and detection in UV-Vis-IR optical ranges. Concealment of target signature was observed in 400 nm, 500 nm, 600 nm, 700 nm, 2200 nm and 2500 nm when Cr oxide coated PA-6,6 fabric was scanned in 22,948 μs (microsecond)-Vis-HSI and 10,500 μs-IR-HSI. The optical reflection and CIE-chromaticity of Australian grass, Bothriochloa Pertusa, woodland CB and Cr oxide coated PA-6,6 fabric have been observed similarity under UV-Vis-IR optical assessment.
In vitro and in vivo evaluation of a bio-inspired adhesive for bone fixation
Authors: Schlund Matthias , Dartus Julien , Defrançois Sarah , Ferri Joël , Delattre Jerôme , Blanchemain Nicolas , Woisel Patrice , Lyskawa Joël , Chai Feng 
Published: January 2023

Abstract
Background: Compared to metallic hardware, an effective bone adhesive can revolutionize the treatment of clinically challenging situations such as comminuted, articular and pediatric fractures. The present study aims at developing such a bio-inspired bone adhesive, based upon a modified mineral-organic adhesive with tetracalcium phosphate (TTCP) and phosphoserine (OPS) by incorporating nanoparticles of polydopamine (nPDA).
Methods: The optimal formulation was screened using in vitro instrumental traction tests. Adhesion to bone, cohesion, setting time, and biomineralization of the optimized adhesive was then assessed with ex vivo instrumental and manual tests, compression tests, setting time measurement and simulated body fluid assay. Cytotoxicity was assessed by extraction test (ISO 10993-5). A new in vivo model was developed: the rat fibula was glued to the ipsilateral tibia, simulating the clinical scenario of autograft fixation under low mechanical load. Analysis was performed clinically, radiologically with micro-computed tomography and histologically (without decalcification).
Results: The optimal formulation was found as 50%molTTCP/50%molOPS-2%wtnPDA with a liquid-to-powder ratio of 0.21 mL/g. This adhesive has a substantially stronger adhesive strength (1.0–1.6 MPa) to bovine cortical bone (after a 24-hour soak in a physiological saline) than the adhesive without nPDA (0.5–0.6 MPa), and is more quickly induced and has more abundant surface mineralization when immersed in simulated body fluid. Moreover, non-cytotoxicity of this adhesive was confirmed in vitro. In vivo, the TTCP/OPS-nPDA adhesive (n=7) was shown to be effective in stabilizing the graft without displacement (clinical success rate of 86% and 71% respectively at 5 and 12 weeks) compared to a sham control (0%). Significant coverage of newly formed bone was particularly observed on the surface of the adhesive, thanks to the osteoinductive property of nPDA.
Conclusions: To conclude, the TTCP/OPS-nPDA adhesive fulfilled many clinical requirements for the bone fixation, and potentially could be functionalized via nPDA to offer more biological activities, e.g. anti-infection after antibiotics loading.
Trial Registration: Not applicable
Risk factors of Traumatic Myocardial Contusion and Establishment of Nomogram Prediction Model
Authors: Yu Changyong , Song Yuekun , Liu Wuxin , Chen Xiang , Zhu Kangyu , Zhu Xinfeng 
Published: January 2023

Abstract
Objectives
To clarify the risk factors of traumatic myocardial contusion (MC) and to build an MC prediction model and assess its clinical application values.
Methods
The clinical data of 370 rib fracture patients treated upon emergency call in the Department of Thoracic Surgery at Jiangsu Shengze Hospital Affiliated to Nanjing Medical University between January 2017 and December 2019 were retrospectively analyzed. Of them, 159 patients were diagnosed as MC. All patients were fully randomly divided at a 7:3 ratio to a training cohort (264 cases, 106 MC cases, 158 NMC cases) and a validation cohort (106 cases, 53 MC cases, 53 NMC cases). The related risk factors of MC in the training cohort were identified via univariate Logistics regression, then the optimal independent risk factors were screened out using LASSO regression and multivariate Logistics regression. A Nomogram model for MC prediction in the training cohort was built with the selected independent risk factors. The receiver's operating characteristic (ROC) curves and calibration curves in the two cohorts were plotted and used to analyze the prediction efficacy of the Nomogram model, and the clinical application value of the model was assessed using decision curve analysis (DCA) and clinical impact curves (CIC).
Results
The multivariate Logistics regression and LASSO regression analysis showed there were five independent risk factors of MC, including the upper chest anterolateral segment (UAL), the middle chest proximal spinal segment (MSS), sternal fracture (SF), Pneumothorax and aspartic transaminase (AST). The ROC curves showed the Nomogram model based on the C index had discrimination of 0.838 (95%CI, 0.790–0.886) and 0.846 (95%CI, 0.770–0.921) in the training cohort and the validation cohort respectively. The calibration curves showed there was high predictive precision between the actual probability and predicted probability in both cohorts. DCA showed at threshold probability > 0.1, the Nomogram model had significant clinical net benefits in both cohorts. CIC showed at the threshold probability > 0.6, the predicted number of positive patients was basically consistent with the actual number.
Conclusions
SF, UAL, MSS, Pneumothorax and AST are the independent risk factors and predictors of MC in rib fracture patients. The Nomogram model based on the 5 independent risk factors has high discrimination, calibration and clinical net benefits, and shows extensive prospects for clinical application in basic hospitals.
Overcoming Small-Bandgap Charge Recombination in Visible and NIR-Light-Driven Hydrogen Evolution by Engineering the Polymer Photocatalyst Structure
Authors: Elsayed Mohamed , Abdelah Mohamed , Mekhemer Islam , Aboubakr Ahmed , Mohamed Mohamed , Kuo Shiao-Wei , Hung Chen-Hsiung , Chen Li-Chyong , Chen Kuei-Hsien , Chou Ho-Hsiu 
Published: January 2023

Abstract
Designing an organic polymer photocatalyst for efficient hydrogen evolution with visible and near-infrared (NIR) light activity is still a major challenge. Unlike the common behaviour of increasing the charge recombination gradually while shrinking the bandgap, here we present a series of polymers nanoparticles (Pdots) based on ITIC and BTIC units with different π-linkers between the acceptor-donor-acceptor (A-D-A) repeated moieties of the polymer, which acts as an efficient single polymer photocatalyst for H2 evolution under both visible and NIR light without combining or hybridizing with other materials. Importantly, the difluorothiophene (ThF) π-linker facilitates the charge transfer between acceptors of different repeated moieties (~ A-D-A-(π-Linker)-A-D-A~) leading to enhancement of charge separation between D and A. As a result, the PITIC-ThF Pdots exhibit superior hydrogen evolution rates of 339.7 mmol g− 1 h− 1 (0.279 mol/h) and 4100 µmol g− 1 h− 1 (20.5 µmol/h) with visible (> 420 nm) and NIR (> 780 nm) light irradiation, respectively. Furthermore, PITIC-ThF Pdots exhibit a record-breaking apparent quantum yield (AQY) at 700 nm (4.76%).
Bring It Up: An Adapted Collaborative Care Model for Depression in a Safety-net Primary Care Clinic
Authors: Ochoa-Frongia Lisa , Garcia Maria E. , Bendahan Tamara , Ponce Andrea N. , Pumar Margo , Yee Karen , Schillinger Dean , Loewy Rachel , Mangurian Christina 
Published: January 2023

Abstract

Background

While over 90 clinical trials demonstrate the efficacy of the collaborative care model (CCM) to treat depression in primary care, there is significant variability in real-world CCM implementation and scalability. Our objective was to determine the feasibility and effectiveness of an adapted CCM in a safety-net primary care setting.

Methods

Bring It Up! (BIU) is a pilot trial comparing an adapted CCM (intervention group) to usual care (historical controls) for patients with depression in a primary care safety-net clinic. Inclusion criteria: 1) age ≥ 18; 2) PHQ-9 score ≥ 10; and 3) major depressive disorder diagnosis. We included patients who completed ≥ 6 months of treatment upon rolling enrollment (4/1/18 − 10/31/19). Historical controls completed ≥ 6 months of usual care in 2017. BIU included all aspects of CCM except accountable care and leveraged existing staff rather than a dedicated care manager. Referring PCPs received evidence-based depression care training, and the team enrolled patients and delivered depression care. Usual care consisted of appointments with PCP and behavioral health staff if referred by PCP. The primary outcome was depression remission (PHQ-9 < 5) within six months. Other depression care secondary outcomes included depression response and adherence to treatment guidelines. We also collected care coordination process outcomes. Data were extracted from the electronic health record.

Results

Thirty-six patients received the BIU intervention; 41 controls received usual care. Depression remission was achieved in 35.3% of intervention patients and 0% of controls (p = 0.001); and 47.1% of intervention patients achieved ≥ 50% reduction in PHQ-9 compared to 9.1% of controls (p = 0.003). Further, 72.7% of intervention patients had guideline-recommended antidepressant medication titration compared to 35.5% of controls (p = 0.003); 94.4% of intervention patients had PHQ-9 repeated compared to 53.7% of controls (p < 0.001).

Conclusions

An adapted CCM was feasible and improved depression care in a safety-net clinic.

Trial registration

Retrospectively registered with UCSF IRB on 12/22/2020. UCSF IRB number: 20-31424
Antiviral activity of Ugandan medicinal plants against human immunodeficiency virus type-1 (HIV-1)
Authors: Anywar Godwin , Kakudidi Esezah , Oryem-Origa Hannington , Schubert Andreas , Jassoy Christian 
Published: January 2023

Abstract
Introduction: In Uganda, many people living with HIV/AIDS (PLHIV) use untested herbs for therapy
Aim: The aim of this study was to investigate the anti-HIV-1 activity of selected plant species.
Methods: Twenty-two 22 plant extracts were tested against HIV-1 Pseudovirions (PV) HXB2 (IIIB) strain in using the human glioblastoma cell line; U87.CD4.CXCR4, transfected with the luciferase firefly reporter gene. The selective inhibition of the growth of HIV-1 PV was measured using the selectivity index (SI). The in vitro cytotoxicity of each of the plant extracts was also evaluated using the AlamarBlue cell viability assay on U87.CD4.CXCR4 cells.
Results: The ethanol and DMSO extracts of Cryptolepis sanguinolenta (Lindl.) Schltr., (SI = 74.7 and 56.3), Psorospermum febrifugium Spach (SI = 54.1 and 47.5) and B. micrantha (SI = 25.3 and 38.7), exhibited the highest SI against HIV-1 PV. Conclusion: Some of the plant extracts tested have potential antiviral activity against HIV-1.
Performance of a Single Slope Solar Still Using Different Porous Absorbing Materials: An Experimental Approach
Authors: Ramzy Khaled , Abdelgaleel Mohmed , kabeel abd elnaby , Mosalam Heba 
Published: January 2023

Abstract
The desalination process is important for converting seawater drinking water in many arid regions of the world. Solar stills are considered one of the best economical solutions to overcome the shortage of water despite of the limitations in its productivity. In this research two, similar solar stills were designed and fabricated and different absorbing materials were used to increase productivity and enhance the still’s performance. These materials are luffa, black luffa, fine steel wool and, steel wool pads and the performance of the two solar stills were evaluated at the same climate conditions. Different parameters were measured such as the still productivity, solar intensity, temperature, and wind velocity to calculate the still thermal efficiency and the exergoeconomic analysis. The results concluded that the still productivity was about 1.872, 2.923, 3.325, 3.712, and 4.384 l/m2 for conventional solar still (CSS), solar still with luffa (CSS-NLF), with black luffa (CSS-BLF), with fine steel wool (CSS-FSW) and with steel wool pads (CSS-SWP) respectively. The thermal efficiency ratings were roughly for the comparable values 17.13, 21.22, 24.71, 28.60 and 32.74% respectively. In addition, the cost per liter (CPL) for these solar stills was about 0.0082, 0.0058, 0.0049, 0.004,4 and 0.0034 $/l/m2 respectively. Finally the payback period and the exergoeconomic analysis were performed and evaluated for these modifications and the findings cleared that using steel wool pads showed a promising performance compared with the other modifications.
Molecular characterization of a new probiotics Ligilactobacillus salivarius F14 from the gut of Tribes of Odisha
Authors: Dash Jayalaxmi , Sethi Manisha , Deb Sushanta , Parida Deepti , Kar Salona , Mahapatra Soumendu , Minz Aliva P , Pradhan Biswaranjan , Prasad Punit , Senapati Shantibhusan 
Published: January 2023

Abstract
Characterization of new potential probiotics is desirable in the field of research of probiotics for their extensive use in health and disease. Tribes could be unusual source of probiotics due to their unique food habits and least dependence on medications and consumption of antibiotics. The aim of the present study is to isolate lactic acid bacteria from tribal fecal samples of Odisha, India, and characterize their genetic and probiotic attributes. In this context one of the catalase-negative and Gram-positive isolates, identified using 16S rRNA sequencing as Lactobacillus salivarius,was characterized in vitro for its acid and bile tolerance, cell adhesion and antimicrobial properties. The whole genome sequence was obtained and analyzed for strain level identification, presence of genomic determinants for probiotic-specific features, and safety. Genes responsible for its antimicrobial and immunomodulatory functions were detected. The secreted metabolites were analyzed using high resolution mass spectroscopy; the results indicated that the antimicrobial potential could be due to the presence of pyroglutamic acid, propionic acid, lactic acid, 2-hydroxyisocaproic acid, homoserine, and glutathione, and the immuno-modulating activity, contributed by the presence of short chain fatty acids such as acetate, propionate, and butyrate. So, to conclude we have successfully characterized a Ligilactobacillus salivarius species with potential antimicrobial and immunomodulatory ability. The health-promoting effects of this probiotic strain and/or its derivatives will be investigated in future.