bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arylamino‐substituted Rhodamine as a Fluorogenic Molecular Rotor for the Wash‐free Imaging of Non‐catalytic Proteins in Live Cells
Authors: Tang Huiling , Yuan Xia , Chen Yefeng , Li Yuyao , Xu Xiaoyong , Xie Hexin 
Published: July 2023

AbstractFluorescent probes are valuable tools to visualize non‐catalytic proteins in live cells. Currently, the majority of imaging reagents for non‐catalytic proteins are based on “always‐on” fluorophores and the use of these reagents usually necessitate a wash step to remove unbounded fluorophores before microscope imaging. Herein, we report the use of arylamino‐substituted rhodamine as an activatable fluorophore for the imaging of non‐catalytic protein in live cells. We have shown the induction of an arylamino to structurally rigid rhodamine could significantly reduce the fluorescent emission in aqueous medium but the ligand‐directed binding of this molecule to protein receptor could effective restrict its intramolecular motion and thus lead to enhancement in fluorescence intensity at 590 nm over 30‐fold. With fluorescent probes based on this fluorophore, we could visualize integrin αvβ3 and azido‐functionalized glycans in living cells with high contrast in a wash‐free manner.
Thermodynamic investigation on low GWP drop‐in alternatives to HFC‐245fa in ejector refrigeration cycle for air condition application
Authors: Hao Xinyue , Gao Neng , Wang Xuehui , Li Nian , Chen Guangming , Wang Qin 
Published: July 2023

AbstractThe ejector refrigeration cycle (ERC) with HFC‐245fa can achieve high efficiency and reliability for air conditioning applications. However, because of its high global warming potential (GWP), HFC‐245fa needed to be phased out according to recent relative regulations. In this study, four promising alternatives to HFC‐245fa were investigated and evaluated, including HC‐600, HCFO‐1233zd(E), HFO‐1336mzz(Z), and HCFO‐1224 yd(Z). Besides their low GWP, these alternatives also have similar vapor pressure curves to HFC‐245fa, which represents a possibility for refrigerant drop‐in replacement in ERC. Thermodynamic real gas modeling of the ERC was adopted in this study for more accurate results, and a critical performance evaluation and comparison with those candidates in ERC were carried out. The results indicate that HCFO‐1233zd(E) and HCFO‐1224 yd(Z) are outstanding candidates for ERC according to the higher coefficient of performance, entrainment ratio, exergy efficiency, and lower pump power consumption, and the COP relative differences of these two refrigerants would reach 5.5% and 4.6%. HFO‐1336mzz(Z) consumes 33% less power at the pump than HFC‐245fa under the same conditions and refrigeration capacity. Minimal pump power consumption is its advantage. Although HC‐600 is prominent, with the largest coefficient of performance and entrainment ratio, its flammability is not conducive to its popularization. Machine learning is available to predict the performance of ejectors employing different refrigerants. This paper helps to properly select refrigerants for ERC and to pre‐evaluate the refrigerants' application under different working conditions.
Measurement of 6‐cyanodopamine, 6‐nitrodopa, 6‐nitrodopamine and 6‐nitroadrenaline by LC–MS/MS in Krebs–Henseleit solution. Assessment of basal release from rabbit isolated right atrium and ventricles
Authors: Júnior Gilberto Quirino , Britto‐Júnior José , Magalhaes Tainah Babadopulos , Campos Rafael , Nyamkondiwa Kudzai L. , Klugh Kameron L. , Peterson Larryn W. , Corvino Angela , Sparaco Rosa , Frecentese Francesco , Caliendo Giuseppe , De Nucci Gilberto 
Published: July 2023

AbstractThis study presents the validation of a sensitive method for the determination of 6‐nitrodopa, 6‐nitrodopamine, 6‐nitroadrenaline and 6‐cyanodopamine in Krebs–Henseleit solution by LC–MS/MS with ESI+. HRMS was used to precisely characterize the structures of the fragment ions. The method was applied to investigate the catecholamine basal release from rabbit isolated atria and ventricles. The atria and ventricles were suspended separately in a 5 ml organ bath containing Krebs–Henseleit solution with ascorbic acid (3 mM), gassed (95%O2/5%CO2) at 37°C for 30 min. Strata‐X 33 μm SPE cartridges were employed for the extraction of the catecholamines and the internal standard 6‐nitrodopamine‐d4. The catecholamines were separated employing a 150 × 3 mm Shim‐pack GIST C18‐AQ (3 mm particle size), placed in an oven at 40°C and perfused by 65% of mobile phase A (MeCN/H2O; 90/10, v/v) + 0.4% CH3COOH and 35% mobile phase B (deionized H2O) + 0.2% CH2O2 at 320 μl/min in isocratic mode. The method was linear at 0.1–20 ng/ml. The method was used to identify for the first‐time basal release of the three nitrocatecholamines mentioned above and a member of a novel class of catecholamines, the cyanocatecholamines.
Endovascular treatment of acute basilar artery occlusion: A systematic review and meta‐analysis of first‐line stent retriever versus direct aspiration
Authors: Zhang Juan , Wang Yongbin , Ju Yanmei , Jiang Hongxin 
Published: July 2023

AbstractBackgroundThe best choice between first‐line aspiration and stent retriever for acute basilar artery occlusion remains controversial. This study aims to perform a systematic review and meta‐analysis comparing the stent retriever and direct aspiration about reported recanalization rates and periprocedural complications.MethodPubMed, Embase, Web of Science, Cochrane, and Clinical Trials were searched for the studies evaluating the efficacy and safety of first‐line aspiration versus stent retriever for acute basilar artery occlusion. A standard software program (Stata Corporation) was used for end‐point analyses. Statistical significance was defined as a p‐value less than .05.ResultsA total of 11 studies were involved in the current study, including 1014 patients. Regarding postoperative recanalization, the pooled analysis identified a significant difference in successful recanalization (odds ratio [OR] = 1.642; 95% confidence interval (95% CI): 1.099–2.453; p = .015) and complete recanalization (OR = 3.525; 95% CI: 1.306–2.872; p = .001) between the two groups in favor of the first‐line aspiration. Concerning the complications, the first‐line aspiration could achieve a lower rate of total complication (OR = .359; 95% CI: .229–.563; p < .001) and hemorrhagic complication (OR = .446, 95% CI: .259–.769; p = .004) than stent retriever. No significant difference was observed in postoperative mortality (OR = .966; p = .880), subarachnoid hematoma (OR = .171; p = .094), and parenchymal hematoma (OR = .799; p = .720). In addition, the pooled results revealed a significant difference in procedure duration between the two groups in favor of aspiration (WMD = −27.630, 95% CI: −50.958 to −4.302; p = .020). However, there was no significant difference in favorable outcome (OR = 1.149; p = .352) and rescue therapy (OR = 1.440; p = .409) between the two groups.ConclusionGiven that the first‐line aspiration was associated with a higher rate of postoperative recanalization, a lower risk of postoperative complication, and a faster duration of the procedure, these findings support the aspiration may be more secure than a stent retriever.
A Concise Review on Natural Products and Their Derivatives for Breast Cancer Treatment
Authors: Gupta Nidhi , Kumar Hitesh , Gupta Sumeet , S. M. Basavarajaiah , Saini Kamal 
Published: July 2023

AbstractCancer is a leading cause of death worldwide. Among other cancers, breast cancer has been found to produce maximum number of cases in 2020. Different factors including geographical, genetic, hormonal, oral contraceptives and modern lifestyle could be responsible for the development of breast cancer and different pathways can be targeted for breast cancer treatment. The various conventional approaches used for the treatment of breast cancer including radiotherapy, chemotherapy, hormone and immunotherapy. But due to the side effects associated with these conventional treatments such as non‐selectivity, multidrug resistance and bioavailability, there is a need for the development of better therapeutic agents for breast cancer treatment. Several natural products have been explored for breast cancer treatment. However, many of these natural products suffered from the limitations of poor water solubility and possess toxic side effects. To overcome these limitations, several structural analogs of natural products have been synthesized and possess potent anti‐breast cancer effects with less side effects over their precursor molecules. In the present manuscript, we describe the pathogenesis of breast cancer, some potent natural products used in the treatment of breast cancer and their selected structural analogs possessing potent anti‐breast cancer effects. Database such as Science direct, Pubmed and Google scholar were searched using keywords ‘risk factors’, ‘screening methods’,'receptors’, and ‘natural products and derivatives’, Registered clinical trials on selected natural products were also analyzed. Present study concludes that eight selected natural products and their derivatives possess wide potential to exhibit anti‐breast cancer effects and could be explored further to develop better chemotherapeutic agents against breast cancer.
Synthesis of Short Peptides with Perfluoroalkyl Side Chains and Evaluation of Their Cellular Uptake Efficiency
Authors: Kadota Koji , Mikami Toshiki , Kohata Ai , Morimoto Jumpei , Sando Shinsuke , Aikawa Kohsuke , Okazoe Takashi 
Published: July 2023

AbstractWith an increasing demand for macromolecular biotherapeutics, the issue of their poor cell‐penetrating abilities requires viable and relevant solutions. Herein, we report tripeptides bearing an amino acid with a perfluoroalkyl (RF) group adjacent to the α‐carbon. RF‐containing tripeptides were synthesized and evaluated for their ability to transport a conjugated hydrophilic dye (Alexa Fluor 647) into the cells. RF‐containing tripeptides with the fluorophore showed high cellular uptake efficiency and none of them were cytotoxic. Interestingly, we demonstrated that the absolute configuration of perfluoroalkylated amino acids (RF‐AAs) affects not only nanoparticle formation but also the cell permeability of the tripeptides. These novel RF‐containing tripeptides are potentially useful as short and noncationic cell‐penetrating peptides (CPPs).
Decreased expression of RPL15 and RPL18 exacerbated the calcification of valve interstitial cells during aortic valve calcification
Authors: Wang Guokun , Qin Ming , Zhang Boyao , Yan Yan , Yang Fan , Chen Qian , Liu Yang , Qiao Fan , Ni Yiming 
Published: July 2023

AbstractCalcific aortic valve disease (CAVD) is the most common valvular heart disease, with an increasing prevalence due to an aging population. The pathobiology of CAVD is a multifaceted and actively regulated process, but the detailed mechanisms have not been elucidated. The present study aims to identify the differentially expressed genes (DEGs) in calcified aortic valve tissues, and to analyze the correlation between DEGs and clinical features in CAVD patients. The DEGs were screened by microarray in normal and CAVD groups (n = 2 for each group), and confirmed by quantitative real‐time polymerase chain reaction in normal (n = 12) and calcified aortic valve tissues (n = 34). A total of 1048 DEGs were identified in calcified aortic valve tissues, including 227 upregulated mRNAs and 821 downregulated mRNAs. Based on multiple bioinformatic analyses, three 60S ribosomal subunit components (RPL15, RPL18, and RPL18A), and two 40S ribosomal subunit components (RPS15 and RPS21) were identified as the top 5 hub genes in the protein–protein interaction network of DEGs. The expression of RPL15 and RPL18 was also found significantly decreased in calcified aortic valve tissues (both p < .01), and negatively correlated with the osteogenic differentiation marker OPN in CAVD patients (both p < .01). Moreover, inhibition of RPL15 or RPL18 exacerbated the calcification of valve interstitial cells under osteogenic induction conditions. The present study proved that decreased expression of RPL15 and RPL18 was closely associated with aortic valve calcification, which provided valuable clues to find therapeutic targets for CAVD.
Mycotoxin monitoring in Shandong province, China reveals health risks for enterohepatic diseases shifted from environment to diet: Deoxynivalenol, zearalenone and nivalenol in noodles (2019–2020)
Authors: Duan Xinglan , Zhang Yifan , Li Fenghua , Li Wei , Chen Fangfang , Zheng Fengjia , Ming Tonghui , Peng Zhen , Zhao Zhenyu , Ye Dan , Wang Jia‐Sheng , Zhao Xiulan , Zhou Jun 
Published: July 2023

AbstractBackground and ObjectivesHigh levels of deoxynivalenol (DON) contamination in foods can raise health risks for enterohepatic diseases. Here we report our investigation into the trichothecenes (DON, 3‐acetyl‐deoxynivalenol, 15‐acetyl‐deoxynivalenol), zearalenone (ZEA) and nivalenol (NIV) showing in the wheats‐processed noodles in Shandong, China (2019–2020).FindingsThe noodles contamination status of DON in Shandong was closed to that in China in the past 10 years: 4663.9 µg/kg at maximum level, and a range of 57.9–618.8 µg/kg by mean. However, the average levels of DON measured in the noodle samples varied largely by city. Highest levels of DON contamination were found in Binzhou: 709.09 (58.8–3220) µg/kg and Weihai: 684.79 (27.6–3850) µg/kg, respectively. Besides, NIV contamination were averagely 46.99 µg/kg in Binzhou, and ZEA contamination up to 31.4 µg/kg in Weihai, pose an increasing threat of liver/intestine inflammation associated with dietary exposure.ConclusionsThe DON contamination status of noodles in Shandong was consistent with our previous investigation in wheats and in recent 10 years in China, that increased health risks for enterohepatic diseases.Significance and NoveltyTo understand the contamination situation of DON, ZEA, and NIV in noodles, so as to assess the health risks for enterohepatic diseases caused by mycotoxin in Shandong province.
Efficient Nitric Oxide Scavenging by Urea‐Functionalized Push‐Pull Chromophore Modulates NO‐Mediated Diseases
Authors: Shekar Roy Himadri , K M Neethu , Rajput Swati , Sadhukhan Sreyanko , Gowri Vijayendran , Hassan Dar Arif , Monga Malika , Salaria Navita , Guha Rajdeep , Chattopadhyay Naibedya , Jayamurugan Govindasamy , Ghosh Deepa 
Published: July 2023

AbstractThe excess nitric oxide (NO) produced in the body in response to bacterial/proinflammatory stimuli is responsible for several pathological conditions. The current approaches that target the production of excess NO, either through the inhibition of nitric oxide synthase enzyme or its downstream mediators have been clinically unsuccessful. With an aim to regulate the excess NO, urea‐functionalized push‐pull chromophores containing 1,1,4,4‐tetracyanobuta‐1,3‐dienes (TCBD) or expanded TCBD (eTCBD) were developed as NO scavengers. The NMR mechanistic studies revealed that upon NO binding, these molecules are converted to uncommon stable NONOates. The unique emissive property of Urea‐eTCBD enables its application in vitro, as a NO‐sensor. Furthermore, the cytocompatible Urea‐eTCBD, rapidly inactivated the NO released from LPS‐activated cells. The therapeutic efficacy of the molecule in modulating NO‐mediated pathological condition was confirmed using a carrageenan‐induced inflammatory paw model and a corneal injury model. While the results confirm the advantages of scavenging the excess NO to address a multitude of NO‐mediated diseases, the promising sensing and bioactivity of Urea‐eTCBD can motivate further exploration of such molecules in allied areas of research.
Isolable Bis‐BN‐Based Analogues of Müller's Hydrocarbon
Authors: Xu Sha , Xie Zhuofeng , Dai Yuyang , Liu Xiaona , Bao Qidi , Liu Chunmeng , Su Yuanting 
Published: July 2023

Comprehensive SummaryMüller's hydrocarbon and its analogues are classical examples of Kekulé diradicaloids and have gained great attention. However, because of their high reactivities, their isolation and structural characterizations are still challenging. Herein, we report the isolation of two bis‐BN‐based analogues of Müller's hydrocarbon (1 and 2) as crystalline solids in moderate yields. Experimental results and theoretical studies demonstrated that compound 1 possessing the terminal 1,3,2‐diazaboryl groups is an open‐shell singlet diradicaloid, which is in contrast to the closed‐shell singlet ground states of the bis‐BN‐based analogues of Thiele's and Chichibabin's hydrocarbons with the same terminal groups, illustrating the strong influence of the central linkers on the ground state. Additionally, the replacement of the terminal 1,3,2‐diazaboryl groups in 1 with the bis(2,4,6‐triisopropylphenyl)boryl groups affords 2 with higher diradical character and a smaller singlet‐triplet energy gap.
Social determinants of health and hypertension in women compared with men in the United States: An analysis of the NHANES study
Authors: Wang Li , Zhang Hao , Yao Hong , Gong Chunlin , Zhong Jiaoyue , Liu Dongxue , Liang Zhaoguang 
Published: July 2023

AbstractBackgroundSocial determinants of health (SDH) reflecting social deprivation have been developed for population health management. There is a paucity of data on the prevalence of SDH and its associations with prevalent hypertension in women compared with men.MethodsA total of 49 791 participants aged over 20 years from the 1999–2018 National Health and Nutrition Examination Surveys, were included. Information on the SDH, including race/ethnicity, education level, family income, housing, marriage status, employment, were collected. We calculated the prevalence ratio (PR) for each adverse SDH with prevalent hypertension and uncontrolled hypertension by using Cox regression with equal times of follow‐up assigned to all individuals with adjustment for age, diabetes, taking lipid‐lowering medication, and health behaviors. The population‐attributable fractions (PAF) of the SDH were also assessed.ResultsA lower proportion of low education attainment was observed in women than men (women: 16.8% vs. men: 17.9%, p = .003), but women had higher proportions of low family income (15.3% vs. 12.5%, p < .001), unmarried state (47.3% vs. 40.9%, p < .001), and unemployment (22.7% vs. 10.7%, p < .001). All the SDH was significantly associated with hypertension in women. There were significant dose–response associations between the numbers of adverse SDH with hypertension. The total PAF of SDH for prevalent hypertension was greater in women (22.2%) than in men (13.9%).ConclusionsThe widely influential SDH is associated with prevalent hypertension and uncontrolled hypertension. To improve hypertension management, health resources should prioritize socioeconomically disadvantaged groups considering gender differences.
Reactive power control of hybrid systems using improved coyote optimizer
Authors: Chen Lin , Yi Xianzhong , Zhou Yuanhua , Liu Lijun , Liu Hangming , Razmjooy Saeid 
Published: July 2023

SummaryA new method of reactive power control by photovoltaic and hydrogen is presented in this study. Photovoltaic has been employed for harvesting the hydrogen which is based on considering the weather conditions. The proposed system includes a combination of photovoltaic, hydrogen, and fuel cell along with a DG to connect to the grid and to improve the supply power quality. The main contribution of this paper is to direct an improved metaheuristic algorithm, called improved coyote optimization (CO) algorithm for achieving a proper DG placement. The improved version of the CO algorithm has benefitted from a spiral policy that is derived from Whale optimization algorithm. This process makes better control for the social behavior of the coyotes. Reactive power optimization (RPO) has been established after the size selection objective function. Big data technology is also used for improving the historical solution matching‐based RPO appliance. Cosine distance is used for measurement purposes of the historical solution matching‐based similarity technique during the computation time of conventional RPO and PVH‐FC features. As a result of using the suggested CO, the costs for electricity and losses are reduced by around 86.6% and 26.9%, respectively. Additionally, realized profits showed that applying the suggested strategy reduced the overall cost from 9.315e6 to 4.435e6 units. After optimization, the network loss and power are finally reduced to 1325 Kvar and 1371 kW, respectively. The results show that the suggested RPO technique has higher speed of calculation in comparison with some latest algorithms. Achievements also show that the suggested method provides a proper and optimal solution for RPO.
Rupture of ectopic varices of the ascending colon occurring after pancreatic cancer surgery: A case report and literature review
Authors: Inomata Yushi , Naito Takeo , Hiratsuka Takashi , Shimoyama Yusuke , Moroi Rintaro , Shiga Hisashi , Kakuta Yoichi , Kayada Kimiko , Ohara Yuki , Asano Naoki , Aoki Shuichi , Unno Michiaki , Masamune Atsushi 
Published: July 2023

AbstractA 69‐year‐old woman, a long‐term survivor of subtotal stomach‐preserving pancreatoduodenectomy with the splenic vein resection for pancreatic cancer, visited our hospital with a chief complaint of bloody stools. Previously, she was diagnosed with varices in the ascending colon due to left‐sided portal hypertension after pancreatoduodenectomy by computed tomography and colonoscopy. After emergency hospitalization, she went into shock, and blood tests showed acute progression of severe anemia. Computed tomography showed a mosaic‐like fluid accumulation from the ascending colon to the rectum. She was diagnosed with ruptured varices in the ascending colon. Emergency colonoscopy was performed, and treatment with endoscopic injection sclerotherapy using N‐butyl‐2‐cyanoacrylate was successful. Ectopic varices occur at any location other than the esophagus and stomach, and colonic varices are rare among them. They are mostly caused by portal hypertension due to liver cirrhosis. However, with the trend of improving the prognosis for patients with pancreatic cancer, we should occasionally pay attention to the development of ectopic varices including colonic varices in patients who have undergone pancreatoduodenectomy with superior mesenteric and splenic veins resection. Treatment methods for colonic varices varied from case to case, including conservative therapy, interventional radiology, and endoscopic procedure. In this case, endoscopic injection sclerotherapy was successfully performed without any complications. To the best of our knowledge, this is the first study to report successful treatment with endoscopic injection sclerotherapy for varices in the ascending colon caused by left‐sided portal hypertension after pancreatoduodenectomy. Colonic varices should be considered in patients with obscure gastrointestinal bleeding after pancreatoduodenectomy.