bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adomian decomposition method for solution of fourteenth order boundary value problems
Authors: Khalid Aasma , Naeem Muhammad Nawaz , Jamal Neelam , Askar Sameh , Ahmad Hijaz 
Published: March 2023

Abstract
Differential equations (DEs) performed a vital role in the implementation of almost all the mechanical, physical, or biological processes. Higher order DEs had always been challenging to solve for the researchers so numerous numerical techniques were developed to attain the vital numerical approximations of such types of problems. In this work, highly advanced numerical techniques are established for the approximation of the fourteenth (14th)-order boundary value problems using Adomian decomposition method. The mathematical outcomes of the equations are attained in the form of convergent series that have effortlessly assessable components having step size h = 10. Some numerical examples are also deliberated to demonstrate the capability and application of the established procedure.
Xanthoangelol, geranilated chalcone compound, isolation from pudau leaves (Artocarpus kemando Miq.) as antibacterial and anticancer
Authors: Suhartati Tati , Andriyani Novita , Yandri Yandri , Hadi Sutopo 
Published: March 2023

Abstract
From the leaves of Artocarpus kemando Miq, locally known as pudau plant, a flavonoid has been isolated and identified. The compound was then tested as antibacterial agent against Bacillus subtillis and Escherichia coli. The first step of isolation was extraction by maceration using methanol as solvent, and then followed by fractionation using partition treatment and vacuum liquid chromatography. Finally, the compound was purified using column chromatography method. The purity of the compound was evaluated using thin layer chromatography and melting point measurement, and the compound was subsequently characterized using UV–Vis, IR, and NMR spectroscopy. A total of 66.2 mg of the compound was obtained, in the form of yellow needle crystals with a melting point of 142.8–144 °C, which is a compound of geranylated chalcone, xanthoangelol. Xanthoangelol was the first chalcone compound isolated from A. kemando. Antibacterial tests were carried out at varied doses of 0.5; 0.4; and 0.3 mg/disk, and revealed that the compound exhibits high inhibitory power against B. subtillis, but has no activity against E. coli. The anticancer activity of xanthoangelol on MCF-7 cells indicated that the compound has an IC50 value of 7.79 μg/mL, suggesting that the compound possesses an active cytotoxic activity.
Detailed investigation of supersonic film cooling performance in a convergent divergent nozzle
Authors: Chen Lingling , Shi Yongqiang , Yang Haoqi , Shi Yalin , Yang Qingzhen 
Published: March 2023

Abstract
This paper numerically studied supersonic film cooling performance in a convergent divergent nozzle, for the purpose of exploring and extending the knowledge of high-efficient cooling techniques for exhaust nozzles in real working conditions. The work was conducted with a steady state RANS approach with the SST turbulence model. The boundary conditions were chosen to mimic a real engine condition. The slot height and the inlet pressure ratio were varied to investigate the effect of the geometrical condition and flow condition. The flow field was analyzed in detail to study the phenomena of the supersonic secondary flow injected into the transonic flow. Besides the cooling effectiveness, the thrust coefficient and the discharge coefficient for the cooling cases were discussed together with the baseline case, to evaluate the influence of the supersonic coolant injection on the nozzle performance. The work can be a basis for the design of cooling schemes in an aero-engine exhaust nozzle.
SK and Kv4 Channels Limit Spike Timing Perturbations in Pacemaking Dopamine Neurons
Authors: Higgs Matthew H. , Jones James A. , Wilson Charles J. , Beckstead Michael J. 
Published: March 2023

AbstractMidbrain dopamine (DA) neurons are among the best characterized pacemaker neurons, having intrinsic, rhythmic firing activity even in the absence of synaptic input. However, the mechanisms of DA neuron pacemaking have not been systematically related to how these cells respond to synaptic input. The input–output properties of pacemaking neurons can be characterized by the phase-resetting curve (PRC), which describes the sensitivity of interspike interval (ISI) length to inputs arriving at different phases of the firing cycle. Here we determined PRCs of putative DA neurons in the substantia nigra pars compacta in brain slices from male and female mice using gramicidin-perforated current-clamp recordings with electrical noise stimuli applied through the patch pipette. On average, and compared with nearby putative GABA neurons, DA neurons showed a low, nearly constant level of sensitivity across most of the ISI, but individual cells had PRCs showing relatively greater sensitivity at early or late phases. Pharmacological experiments showed that DA neuron PRCs are shaped by small-conductance calcium-activated potassium and Kv4 channels, which limit input sensitivity across early and late phases of the ISI. Our results establish the PRC as a tractable experimental measurement of individual DA neuron input–output relationships and identify two of the major ionic conductances that limit perturbations to rhythmic firing. These findings have applications in modeling and for identifying biophysical changes in response to disease or environmental manipulations.
TFEB‐dependent lysosome biogenesis is required for senescence
Authors: Curnock Rachel , Yalci Katy , Palmfeldt Johan , Jäättelä Marja , Liu Bin , Carroll Bernadette 
Published: March 2023

AbstractThe accumulation of senescent cells is recognised as a driver of tissue and organismal ageing. One of the gold‐standard hallmarks of a senescent cell is an increase in lysosomal content, as measured by senescence‐associated β‐galactosidase (Senβ‐Gal) activity. The lysosome plays a central role in integrating mitogenic and stress cues to control cell metabolism, which is known to be dysregulated in senescence. Despite this, little is known about the cause and consequence of lysosomal biogenesis in senescence. We find here that lysosomes in senescent cells are dysfunctional; they have higher pH, increased evidence of membrane damage and reduced proteolytic capacity. The significant increase in lysosomal content is however sufficient to maintain degradative capacity of the cell to a level comparable to proliferating control cells. We demonstrate that increased nuclear TFEB/TFE3 supports lysosome biogenesis, is a hallmark of multiple forms of senescence and is required for senescent cell survival. TFEB/TFE3 are hypo‐phosphorylated and show constitutive nuclear localisation in senescence. Evidence suggests that several pathways may contribute to TFEB/TFE3 dysregulation in senescence.
Monetary and fiscal policies in the EU. Is there a difference between EMU and non-EMU members?
Authors: Pantovic Danijela , Fedajev Aleksandra , Milošević Isidora 
Published: March 2023

AbstractThe COVID-19 crisis has put the European Union's (EU) ability to respond to external challenges to test. It is not a new issue that has arisen due to the current crisis. The global economic crisis of 2008, and, in particular, the sovereign debt crisis of 2010, highlighted the need for institutional, policy and political reform to ensure the stability and long-term sustainability of the EU project. The EU's asymmetric degrees of integration, in terms of Economic and Monetary Union (EMU) and non-EMU members, resulted in a diverse response to the crisis and, more importantly, mixed-effects from monetary and fiscal policies. This study aims to research the impact of monetary and fiscal policies between 2007 and 2015 on economic growth and employment. The findings show that loose monetary policies at the EU, EMU and non-EMU levels boosted economic growth and development. On the other hand, restrictive fiscal policy had favourably influenced GDP and employment by reducing inflationary pressures produced by expansive monetary policy. However, fiscal policy had a greater impact in the non-EMU countries, demonstrating that this policy can act as a stabilizing force in the face of an overly expansive and common monetary policy. In order to respond effectively to the current and future crises, the EU government should overhaul the way monetary and fiscal policy is conducted and coordinated.
Formulation and evaluation of self-nanoemulsifying drug delivery system for improved oral delivery of exemestane hydrochloride
Authors: Prajapati Bhupendra Gopalbhai , Prajapati Bhavesh , Khunt Dignesh 
Published: March 2023

Exemestane HCl (EXM) is a new irreversible steroidal aromatase inhibitor for adjuvant therapy of hormonally sensitive breast cancer in post-menopausal women. EXM's low water solubility hinders solid oral dosage form development. The current work aims to increase EXM solubility by formulating the self nanoemulsifying drug delivery (SNEDDs) system. The water titration approach was employed in the development of SNEDDs. Based on solubility tests, SNEDDs components Caprol Microexpress and Labrafac were selected as oil phase, Tween 80 as surfactant, and Triacetin as co-surfactant. Phase investigations were carried out with various surfactant:co-surfactant ratios (1:1, 1:2, 1:3, 2:1, 3:1). Tween 80: triacetin (1:2) and (1:3) with Caprol Microexpress and Labrafac alone had the greatest nanoemulsion area. Visual evaluation, optical clarity, particle size, medication concentration, and viscosity were used to optimise 10 formulations. F3, F7, and F8 batches had the lowest size at 7.313 ± 1.44 nm, 6.379 ± 0.45 nm, and 14.67 ± 0.37 nm, respectively, with self-emulsification times under 1 min.But optical clarity data was suggested that F7 was not showing any precipitation up to 24 H. Overall, the developed SNEDDS formulation could be a promising approach for the improved oral delivery of EXE with enhanced dissolution and bioavailability.
Chronologia astronomiczna w pismach Izydora z Sewilli
Authors: Turkiewicz Natalia 
Published: March 2023

Celem tego opracowania była próba rekonstrukcji systemu chronologii astronomicznej wyłaniającego się z prac Izydora z Sewilli. Ich autor buduje strukturę czasu na podstawie najmniejszych jednostek, z których tka większe całości. Jednak bogata egzemplifikacja czasu nie zawiera samej jego definicji. Rozdział Etymologii poświęcony chronologii i czasowi badacz otwiera definicją kroniki i historiografii, które jako wytwór myśli ludzkiej stanowią materialną dokumentację upływu czasu. Dokładna charakterystyka i systematyzacja jednostek czasu ma ułatwić posługiwanie się narzędziami chronologicznymi oraz uświadomić odbiorcy funkcjonowanie przestrzeni chronologicznej. Z tego wynika, że społeczności średniowieczne, głęboko zakorzenione w obrzędowości religijnej, organizowały swoje funkcjonowanie wokół stałych wynikających z obserwacji naukowej i empirycznej. Chronologia zajmuje w twórczości Izydora miejsce szczególne, jednak czas nie ma definicji, a sama kategoria czasu jako spójna całość przenika i łączy wszystkie elementy świata. Wizja czasu i chronologii w tych pismach odcisnęła trwały ślad na ukształtowaniu się myśli chronologicznej i kosmologicznej średniowiecza i czasów nowożytnych.
Illustrissime Princeps, Episcope Reverendissime: How Did John of the Lithuanian Dukes Finance His Life as Prince and Bishop?
Authors: Rowell Stephen C. 
Published: March 2023

From childhood, the son of Sigismund the Old and Catherine Telniczanka, John of the Lithuanian Dukes (1499-1538), knew he was a prince, and so did his contemporaries. However, maintaining a princely estate does not come cheaply. The aim of this article is not to examine in detail the financial records of this princely cleric, for such documents no longer exist, nor shall we speak in general of the official income of the bishops of Vilnius; rather, we shall examine, where the meagre sources permit, how the bishop garnered income from property deals, the patronage of artisans, loans, and tax farming to fund his activities as a prince of the Church and a responsible secular lord. A broad account is given of John’s income and expenditure in childhood, his clerical career in the sees of Płock, Poznań and Vilnius, and his acquisition of property in Šiauliai and Volyn. Attention is also paid to the bishop’s use of the adoption law to his financial advantage.
John was by no means a poor man but he was not as wealthy as he might appear – he promised to pay for building work in Poznań but left debts; he was expected to restore the city walls, but died prematurely. He pledged to present the Poznań cathedral treasury with a golden chalice but left only a debt of 300 złoty; the same goes for the ring he promised on his joyful ingress into his new see. He was economically astute – he built the first glass foundry in Vilnius on condition it provide him with window glass and tableware. He purchased houses and rented them out for long term occupation – the rent of at least three generations of Kirchel burghers in Vilnius funded his mansionary chapel in Vilnius cathedral. He gives the impression of never having enough ready cash at hand, despite obtaining large swathes of financially profitable grand-ducal territory which produced the considerable income he needed to spend on administration.
Consumo de frutas e Insegurança Alimentar em gestantes
Authors: Rangel Clara Christine de Souza , Gomes Daiane Silva , Brandão Thelma , Nascimento Pamela Cristina Brito do , Augusto Ana Lúcia Pires 
Published: March 2023

A insegurança alimentar (IA) definida como limitado acesso a alimentos em quantidade e qualidade adequadas, pode afetar o desenvolvimento de indivíduos mais vulneráveis como gestantes. O objetivo deste estudo foi verificar a associação entre a IA, fatores sociodemográficos e de saúde com o consumo de frutas e hortaliças em gestantes de risco vinculadas a um Hospital de referência da região metropolitana do Rio de Janeiro. A IA foi mensurada por meio da Escala Brasileira de Insegurança Alimentar, os dados sociodemográficos e de saúde foram coletados por meio de entrevistas com 260 gestantes de risco, entre os anos de 2017 e 2020 e foi investigada, através de modelos logísticos, utilizando-se o odds ratio com intervalo de confiança de 95% (OR; IC 95%), a associação entre o baixo consumo de frutas e hortaliças, definido por um consumo inferior a 5 vezes por semana e a exposição à IA, e sua relação com fatores sociodemográficos e de saúde. Não houve associação estatisticamente significativa entre o consumo de hortaliças e a IA, porém, a IA associou-se significativamente ao baixo consumo de frutas (OR=2,1; IC95%=1,02-4,5), a cor/raça preta/parda/indígena aumentou cerca de três vezes a chance do baixo consumo de frutas (OR=3,1;IC95%=1,5-6,3), além do consumo de álcool (OR=2,8;IC95%=1,02-7,7). A proporção de IA encontrada neste estudo revela a alta vulnerabilidade de um grupo já naturalmente mais suscetível a condições de risco à saúde, como as gestantes.
Sustainability of Forage Systems in Small Holder Dairy Cattle in The Plateau in East Java
Authors: Rahardjo L. , Wadjdi M.F. 
Published: March 2023

Abstract. This study aimed to describe the sustainability of forage system in the small holder dairy cattle in the plateau in East Java, in particular related to the nutrient content. The method used was survey (interviews, questionnaires, field observations and sampling) at the cooperation unit, farmers, livestock and farming location in one of the areas of dairy cattle cooperation in the plateau (Cooperation of SAE Pujon-Malang). The data obtained were analyzed through descriptive and regression statistics. The results showed that forage system dominantly given during dry and rainy seasons are elephant grass and corn stalks. Linear regression equation for the nutrient content of elephant grass is TDN= 40.516 + 1.404 CP, while corn trees is TDN= 56.212 + 0.740 CP. The conclusion showed that the dependent variable is largely influenced by external factors (environment). Improved continuity of availability of forage can be done by increasing the feeding system in the region (plateau) as well as the support from outside the region. Key words: plateau, dairy cattle, forage Abstrak. Penelitian ini bertujuan untuk mendiskripsikan keberlanjutan sistem pakan hijauan pada peternakan sapi perah rakyat di wilayah dataran tinggi di Jawa Timur, khususnya tentang kandungan nutrisi. Metode yang digunakan adalah survei (wawancara, pengisian angket/kuesioner, observasi, dan pengambilan sampel) di koperasi, petani ternak dan lokasi peternakan di salah satu wilayah koperasi persusuan di dataran tinggi (Koperasi SAE Pujon-Malang). Data yang didapat dianalisis dengan regresi dan statistik diskriptif. Hasil penelitian menunjukkan bahwa pakan hijaun yang dominan di musim kemarau dan hujan adalah rumput gajah dan tebon jagung. Persamaan regresi linier untuk kandungan nutrisi rumput gajah adalah TDN= 40,516 + 1,404 PK, sedangkan tebon jagung adalah TDN= 56,212 + 0,740 PK. Kesimpulannya adalah variabel dependen sebagian besar dipengaruhi oleh faktor luar (lingkungan). Peningkatan kontinuitas ketersediaan pakan hijauan dapat dilakukan dengan peningkatan sistem pakan di wilayah (dataran tinggi) dan dukungan sistem pakan dari luar wilayah. Kata kunci: dataran tinggi, sapi perah, pakan hijauan
Performance of Mojosari Alabio Males Ducks Fed Complete Ration Silage
Authors: Ridla Muhammad , Allaily Allaily , Nikmah Fitri Kurnia , Ramli Nahrowi 
Published: March 2023

Abstract. The experiment was conducted to determine the effect of complete diet silage on feed consumption, body weight gain, feed conversion, water consumption and mortality. The materials used were 75 Mojosari Alabio male ducks, commercial diet plus rice bran (16.50% CP, 2900 kkal GE/kg), silage with 30-60% water content. Data were subject to Completely Randomized Design with five treatments and three replications. The treatments were S0 (commercial feed), S1 (silage with 30% water content), S2 (silage with 40% water content), S3 (silage with 50% water content) and S4 (silage with 60% water content). Data were subject to analysis of variance followed by orthogonal contrast test. The result showed that silage with 50% water content has significantly increased body weight gain and decreased water consumption, but there were no effect in feed conversion. Complete diet silage was safe for Mojosari Alabio male duck. Key words : complete ration silage , duck, performance Abstrak. Penelitian ini untuk mengetahui pengaruh pemberian silase ransum komplit terhadap konsumsi pakan, pertambahan bobot badan, konversi pakan, konsumsi air dan persentase kematian. Bahan yang digunakan adalah 75 ekor itik Mojosari Alabio jantan, ransum komersial ditambah dedak padi (16,50% CP, 2900 kkal GE/kg), silase dengan kadar air 30-60%. Percobaan ini menggunakan Rancangan Acak Lengkap dengan lima perlakuan dan tiga ulangan. Perlakuan S0 (pakan komersial), S1 (silase dengan kadar air 30%), S2 (silase dengan kadar air 40%), S3 (silase dengan kadar air 50%) dan S4 (silase dengan kadar air 60%). Data dianalisis menggunakan analisis ragam dan dilanjutkan dengan uji kontras orthogonal. Hasilnya menunjukkan bahwa silase dengan kadar air 50% memiliki peningkatan berat badan dan penurunan konsumsi air yang signifikan, tetapi tidak mempengaruhi konversi pakan. Silase ransum komplit pakan aman untuk itik Mojosari Alabio jantan. Kata kunci : silase ransum komplit, itik, performans
Effect of Diet Containing Gracilaria Sp. Waste and Multi-Enzyme Additives on Blood Lipid Profile of Local Duck
Authors: Frasiska Nurul , Suprijatna Edjeng , Susanti Siti 
Published: March 2023

This study was aimed to evaluate the effect of diet containing waste of seaweed Gracilaria sp. on local duck blood lipid profiles including cholesterol, triglycerides, low density lipoprotein (LDL), and high density lipoprotein (HDL). The material in this study were 72 female Tegal ducks aged 22 weeks with 1,318 ± 121 gaverage body weight, diets containing Gracilaria sp. waste (GW) with 18% protein and 2900 kcal/kg metabolic energy and 150 g/ton feed commercial multi-enzyme (ME). Data were subject to Completely Randomized Design with 6 treatments, (T0) Basal Diets, (T0+) Basal Diets with ME, (T1) Diets with 10% GW, (T1+) Diets with 10% GW + ME, (T2+) Diets with 12.5 % GW + ME, and (T3+) Diets with 15% GW + ME. The treatment was givenfor 12 weeks and blood sample was taken onthe last week. The serum was separated and analyzed for blood lipid profiles using CHOD-PAP. Results showed that diet with 12.5%GW plus multi-enzyme additives significantly (P<0.05) affected blood lipid profiles of local duck, tended to lower triglycerides and LDL Cholesterol, but increase blood HDL levels.
Effects of General Anesthesia Plus Multimodal Analgesia on Immediate Perioperative Outcomes of Hamstring Tendon Autograft ACL Reconstruction
Authors: Walczak Brian E. , Bernardoni Eamon D. , Steiner Quinn , Baer Geoffrey S. , Donnelly Melanie J. , Shepler John A. 
Published: March 2023

Background:Anterior cruciate ligament reconstruction with hamstring tendon autograft (H-ACLR) is a standard ambulatory procedure with the potential for considerable postoperative pain. We hypothesized that general anesthesia combined with a multimodal analgesia regimen would reduce postoperative opioid use associated with H-ACLR.Methods:This study was a single-center, surgeon-stratified, double-blinded, placebo-controlled, randomized clinical trial. The primary end point was the total postoperative opioid use during the immediate postoperative period, and secondary outcomes included postoperative knee pain, adverse events, and ambulatory discharge efficiency.Results:One hundred and twelve subjects, 18 to 52 years of age, were randomized to placebo (57 subjects) or combination multimodal analgesia (MA) (55 subjects). The MA group required fewer opioids postoperatively (mean ± standard deviation, 9.81 ± 7.58 versus 13.88 ± 8.49 morphine milligram equivalents; p = 0.010; effect size = −0.51). Similarly, the MA group required fewer opioids within the first 24 hours postoperatively (mean ± standard deviation, 16.56 ± 10.77 versus 22.13 ± 10.66 morphine milligram equivalents; p = 0.008; effect size = −0.52). The subjects in the MA group reported lower posteromedial knee pain (median [interquartile range, IQR]: 3.0 [0.0 to 5.0] versus 4.0 [2.0 to 5.0]; p = 0.027) at 1 hour postoperatively. Nausea medication was required for 10.5% of the subjects receiving the placebo versus 14.5% of the subjects receiving MA (p = 0.577). Pruritis was reported for 17.5% of subjects receiving the placebo versus 14.5% receiving MA (p = 0.798). The median time to discharge was 177 minutes (IQR, 150.5 to 201.0 minutes) for subjects receiving placebo versus 188 minutes (IQR, 160.0 to 222.0 minutes) for those receiving MA (p = 0.271).Conclusions:A combination of general anesthesia and local, regional, oral, and intravenous multimodal analgesia appears to reduce postoperative opioid requirements after H-ACLR compared with placebo. Adding preoperative patient education and focusing on donor-site analgesia may maximize perioperative outcomes.Level of Evidence:TherapeuticLevel I. See Instructions for Authors for a complete description of levels of evidence.