bluuebunny/crossref_metadata_2025_split huggingface dataset:
Issues and Challenges in Pharmacovigilance of Herbal Formulations
Authors: Pai Vasudev , Subraya Chandrashekar Kodangala , Holavana Halli Nanjundaiah Aswatha Ram , Kamath Venkatesh , Kunhikatta Vijayanarayana 
Published: February 2023

Abstract:
Pharmacovigilance is important for generating accurate safety of herbal medications information.
The present methods were designed for synthetic medications and will need to be modified
to account for the unique characteristics of medicinal plants. The objective of pharmacovigilance
is to identify, measure, and explain adverse effects or other potential drug-related issues associated
with herbal, traditional, and complementary therapies, as well as to avoid them. Required
data for pharmcovigilance of herbal drugs and formulation were obtained from electronic sources
(google scholar, PubMed, Scopus, Web of Science), several textbooks. The keywords used to
search for various journal publishers such as Willey Online Library, Springer, Wolters Kluwer and
Elsevier were closely monitored. This review article covers all the relevant information on issues
and challenges in pharmacovigilance of formulation covering Herbal drugs.
Artificial Intelligence in Drug Regulatory Submissions in India
Authors: Shukla Vikesh Kumar , Mittal Manvi Kumar 
Published: February 2023

Abstract:
Regulatory affairs are one of the most crucial connections between the pharmaceutical
company and the other stakeholder’s or regulatory agencies such as FDA, EMA, etc. Strategies in
drug approval and marketing to assure the quality, safety, and efficacy of the drug follow the
guidelines and laws stated under the drug and cosmetic act 1940 and rules 1945. Their primary responsibility
is to keep the company in compliance with changing guidelines, which necessitates
constant monitoring of the most recent industry updates. Drug regulation is a complex process as
every country has its own set of documentation that must be done while regulatory submissions.
From drug development and drug approval to drug commercialisation, there is a large amount of
documentation that must be completed with accuracy, which can be challenging for the professional
to complete, therefore, this leads to the introduction of the concept of big data that can be incorporated
which will map the regulations according to 5vs model of big data. Thus, to make it more
efficient, we can work big data with artificial intelligence to ease the process using natural language
processing. This concept will map all the rules and guidelines together and make a cluster of
similar rules together. Now, users can use the tool to locate the data of interest in a single site in a
more comprised universal language that can be accessed by any professional to complete the task
in the given time schedule.
The Impact of Policy on Principals’ Leadership and Management Skills and Student Achievement in Rural Secondary Schools: A South African Case Study
Authors: Zenda Rekai 
Published: February 2023

Background:Globally, policy and leadership and management skills of principals that are congruent foster future-focused learning and guide teachers and students towards a passion for learning and for growing creatively and collaboratively.Methods:The qualitative research was undertaken and the Cultural-Historical Activity theory was used as a theoretical lens to determine the impact of policy on principals’ leadership and management skills and student achievement.Results:The results showed that policy and leadership and management skills enabled school principals to effectively implement, assess, monitor learning activities, enhanced student behaviour and provision of resources.Conclusion:Implications uncovered in this research include providing school principals with access to training courses to improve their understanding of the teaching and learning methodologies to enhance student achievement, particularly in science.
Dynamic Region of Interest Selection in Remote Photoplethysmography: Proof-of-Concept Study
Authors: Kiddle Adam , Barham Helen , Wegerif Simon , Petronzio Connie 
Published: February 2023

Background
Remote photoplethysmography (rPPG) can record vital signs (VSs) by detecting subtle changes in the light reflected from the skin. Lifelight (Xim Ltd) is a novel software being developed as a medical device for the contactless measurement of VSs using rPPG via integral cameras on smart devices. Research to date has focused on extracting the pulsatile VS from the raw signal, which can be influenced by factors such as ambient light, skin thickness, facial movements, and skin tone.

Objective
This preliminary proof-of-concept study outlines a dynamic approach to rPPG signal processing wherein green channel signals from the most relevant areas of the face (the midface, comprising the cheeks, nose, and top of the lip) are optimized for each subject using tiling and aggregation (T&A) algorithms.

Methods
High-resolution 60-second videos were recorded during the VISION-MD study. The midface was divided into 62 tiles of 20×20 pixels, and the signals from multiple tiles were evaluated using bespoke algorithms through weighting according to signal-to-noise ratio in the frequency domain (SNR-F) score or segmentation. Midface signals before and after T&A were categorized by a trained observer blinded to the data processing as 0 (high quality, suitable for algorithm training), 1 (suitable for algorithm testing), or 2 (inadequate quality). On secondary analysis, observer categories were compared for signals predicted to improve categories following T&A based on the SNR-F score. Observer ratings and SNR-F scores were also compared before and after T&A for Fitzpatrick skin tones 5 and 6, wherein rPPG is hampered by light absorption by melanin.

Results
The analysis used 4310 videos recorded from 1315 participants. Category 2 and 1 signals had lower mean SNR-F scores than category 0 signals. T&A improved the mean SNR-F score using all algorithms. Depending on the algorithm, 18% (763/4212) to 31% (1306/4212) of signals improved by at least one category, with up to 10% (438/4212) improving into category 0, and 67% (2834/4212) to 79% (3337/4212) remaining in the same category. Importantly, 9% (396/4212) to 21% (875/4212) improved from category 2 (not usable) into category 1. All algorithms showed improvements. No more than 3% (137/4212) of signals were assigned to a lower-quality category following T&A. On secondary analysis, 62% of signals (32/52) were recategorized, as predicted from the SNR-F score. T&A improved SNR-F scores in darker skin tones; 41% of signals (151/369) improved from category 2 to 1 and 12% (44/369) from category 1 to 0.

Conclusions
The T&A approach to dynamic region of interest selection improved signal quality, including in dark skin tones. The method was verified by comparison with a trained observer’s rating. T&A could overcome factors that compromise whole-face rPPG. This method’s performance in estimating VS is currently being assessed.

Trial Registration
ClinicalTrials.gov NCT04763746; https://clinicaltrials.gov/ct2/show/NCT04763746
Hipótesis etimológica de kuña ‘mujer’ a partir de un estudio comparado en las lenguas tupí-guaraníes
Authors: Aguilera Jiménez Domingo Adolfo 
Published: February 2023

Este artículo presenta un estudio etimológico de la palabra kuña ‘mujer’ en las lenguas tupí-guaraníes, habladas por varios millones de personas en Paraguay y otros países vecinos. A través de un estudio morfológico y semántico comparado del vocablo en 27 lenguas actuales de la familia Tupí-Guaraní, además de una pesquisa en la documentación histórica de obras antiguas clásicas, se sugiere la hipótesis de que kuña ‘mujer’ etimológicamente puede traducirse como ‘dueña o señora de la cosecha’, ‘guardiana, ama o espíritu de la roza’, ‘dueña del sustento’, entre otras posibilidades. Un acercamiento a la concepción de la mujer desde las culturas indígenas puede sumar un punto de reflexión desde la alteridad, en una materia muy sensible de nuestro tiempo: la construcción de la igualdad de derechos entre hombre y mujer y el cese de toda violencia hacia las mujeres en el mundo.
Karakteristik pelet kayu dari limbah pangkasan teh berdasarkan besaran partikel
Authors: Harianto Sugeng , Prawira-Atmaja Muhammad Iqbal , Shabri Shabri , Maulana Hilman , Rohdiana Dr. Dadan , Rosyadi Achmad Imron 
Published: February 2023

Biomass waste potential from tea pruning was high, however the utilization of the waste still low. Forming pellet from the waste was one of means for utilizing it to have value-added. Pelletization is a process of compressing the material to increase density value, calorific value, and to uniform the particle size. The method in tea pruning waste pelletization used because the waste is consists of dry twigs and leaves so it was easier in reducing the particle size as pellet raw material. This research purpose was to identify the wood pellet characteristics of various particle size from tea pruning waste, consisted of water content, ash content, and wood pellet density against calorific value produce. The material used in this research was tea pruning waste available all years in the experimental plantation of Reserach Institute for Tea and Cinchona Gambung that has been dried for three days. Pelletization process starts with reducing the tea pruning waste particle using Chopper machine to acquire dust particles. Afterward, those dust was separated into three treatments, which are, passed sieve number 7 mesh, 14 mesh, and 18 mesh. Calorific value produced from the wood pellet was the main factor from all pelletization process, the result show that the dust passed sieve number 18, which is the smallest particle size, has the highest calorific y value produced in the amount of 4.431 cal/g
Analisis Pengendalian Mutu Grade Teh Hijau dengan Metode Statistical Quality Control di Pusat Penelitian Teh dan Kina Gambung Kabupaten Bandung
Authors: Feri Ardiyanti  
Published: February 2023

Pengendalian mutu dilakukan mulai dari bahan baku, proses produksi, dan produk akhir agar produk yang dihasilkan sesuai dengan standar yang telah ditentukan. Penelitian ini bertujuan untuk untuk mengetahui pengendalian mutu secara statistik pada grade teh hijau, mengetahui kemampuan proses dalam menghasilkan grade teh hijau, dan mengetahui fakor-faktor yang mempengaruhi grade teh hijau. Analisis data menggunakan metode statistical quality control, yaitu control chart untuk data variabel (Xbar, R-chart, dan S-chart), capability process, dan diagram fishbone. Hasil penelitian dan analisis peta kendali Xbar, menunjukkan bahwa kualitas grade teh hijau tidak terkendali yang ditunjukkan dengan keberadaan titik sebaran data yang berada di luar batas kendali statistik. Analisis peta kendali R dan S dalam proses pengukuran grade teh hijau menunjukkan bahwa secara keseluruhan proses berada dalam batas kendali statistik. Nilai Cp yang diperoleh 0.289 < 1 yang menunjukkan bahwa kapabilitas proses rendah. Nilai Cpk yang diperoleh sama dengan nilai Cp yang berarti proses menghasilkan produk berada tepat di tengah interval spesifikasi. Dari analisis fishbone, faktor-faktor yang dapat mempengaruhi grade teh antara lain tenaga kerja, proses, lingkungan, mesin, dan bahan baku.
Penerapan DFMEA pada Perancangan Produk Casing Lampu Berbahan Dasar Bambu
Authors: Wijaya Erik Odi , Sahrupi Sahrupi , Sofa Mohamad Jihan 
Published: February 2023

This research aims to discover the higest impact of product failures and determine the proper of solution. Design FMEA is a method to anticipate failure during the design stage by identifying all of the possible failures in a design or manufacturing process. This studi conducted in a micro, small and medium-sized enterprises (SMEs). KIM is a small company that produce handycraft product made from bamboo plants, one of the featured product is lamp casing. Any of customers complain encourage the company to make new product design and look for the cause of the problem and risk. The results of this research are obtained 5 components of lamp casing with the highest level of risk. An Improvement was carried out entirely by using a repair priority scale according to the sequence of failure modes with the highest risk of damage.
Ethical implications in the evaluation of complex contexts related to COVID-19
Authors: Copez-Lonzoy Anthony , Vilela-Estrada Ana L , Meléndez-Torres G.J. 
Published: February 2023

Background: The pandemic caused by Sars-cov-2 has generated multiple sustained efforts for its identification, characteristics and mobility of the disease that to date has repercussions worldwide. Given this need, it is necessary to have updated information considering transparent research processes. Method: a critical review of the current literature on COVID-19 research. Conclusions: It is essential to have ethical procedures in the different phases of research that can go beyond personal interests and that guarantee the preservation of people's welfare in the reduction of possible damage to health globally, adequate procedures in the collection of information that is not built to the measure of the researchers, to avoid involuntary segregation of the participants and that this leads to a reduction of significant damage due to implicit biases that are generated by poor planning that pursues the scoop instead of social good.
《二十世紀中國古典文學研究史》
Authors: 楊 乃喬 
Published: February 2023

LANGUAGE NOTE | Document text in Chinese only.
二十世紀是中國從傳統社會全面走向現代社會的世紀，回首一個世紀的歷史變革，從辛亥革命、五四運動到新中國的成立和改革開放，我們不能不驚嘆偉大祖國的進步神速。現代化的歷史大潮帶來的並不僅是科學技術的飛躍和物質文明的極大提高，更帶來了中國人在文化思想方面翻天覆地的變化。因此，在即將進入二十一紀的今天，回首一個世紀以來發生在中國文化思想領域的巨大變化，同樣會使我們激動不已。(撮要取自內文首段)
SUBJECTIVE WELL-BEING (SWB) PADA PEREMPUAN BALI YANG BERSTATUS PEREMPUAN BALU DALAM MASA GRIEVING (SUATU STUDI FENOMENOLOGI DESKRIPTIF)
Authors: Moniex Ni Putu Dhita Maharani , Wilani Ni Made Ari 
Published: February 2023

ABSTRAK Grieving atau berduka merupakan keadaan yang menyebabkan perempuan mengemban status sebagai single mother atau perempuan balu. Perempuan balu merupakan istilah di Bali yang ditujukan kepada perempuan yang menjadi single mother karena kematian pasangan. Menjadi perempuan balu tidak jarang memicu konflik dalam kehidupan karena dalam masa grieving perempuan balu harus mengemban peran ayah di samping tiga perannya yaitu peran domestik, peran produktif, dan peran sosial, serta harus menjalankan awig-awig perempuan balu yang terdapat dalam lingkungan masyarakat. Penambahan peran serta adanya awig-awig membuat kehidupannya semakin tertekan. Keadaan yang tertekan dapat menyebabkan tidak seimbangnya kehidupan individu yang dapat memengaruhi Subjective Well-Being (SWB) individu. SWB merupakan evaluasi kehidupan individu berdasarkan komponen kognitif dan komponen afeksi terhadap kehidupannya. Penelitian ini merupakan penelitian kualitatif dengan pendekatan fenomenologi deskriptif dan unit analisis individual. Penggalian data dalam penelitian ini menggunakan teknik wawancara dan catatan lapangan. Responden dari penelitian ini adalah lima orang perempuan balu dalam masa grieving, memiliki anak laki-laki, bekerja, serta tinggal bersama keluarga suami. Hasil dari penelitian ini menunjukkan bahwa SWB dari kelima responden menurun setelah kematian suami. Hal ini dilihat dari persepsi perempuan balu pasca kematian suami, permasalahan yang muncul pasca kematian suami serta guncangan emosional pasca kematian suami.
EFEKTIVITAS INTERVENSI KECERDASAN EMOSI UNTUK MENCEGAH PERILAKU AGRESI PADA SISWA KELAS VIII DI SMP NURUL ISLAM KUBU RAYA
Authors: Kur'ani Nur 
Published: February 2023

Perilaku agresi yang terjadi di sekolah merupakan salah satu masalah yang sangat mendesak untuk diselesaikan. Oleh karena itu untuk mencegah terjadinya perilaku agresi pada siswa di sekolah diperlukan kecerdasan emosi yang baik agar tercipta lingkungan pendidikan yang aman dan kondusif. Penelitian ini bertujuan untuk mengetahui efektivitas intervensi kecerdasan emosi untuk mencegah perilaku agresi pada siswa kelas VIII di SMP Nurul Islam Kubu Raya. Metode penelitian yang digunakan yaitu metode Mixed-Method. Subyek dalam penelitian ini adalah siswa kelas VIII di SMP Nurul Islam. Jumlah responden yang diteliti sebanyak 34 siswa yang terdiri dari dua kelas yaitu kelas eksperimen yang merupakan kelompok siswa yang diberi perlakuan dan kelas kontrol yang merupakan kelompok siswa yang tidak diberi perlakuan. Penentuan sampel dalam penelitian ini dilakukan dengan teknik purposive sampling. Hasil penelitian menunjukkan intervensi kecerdasan emosi tergolong efektif untuk mencegah perilaku agresi pada siswa kelas VIII di SMP Nurul Islam Kubu Raya. Secara umum dapat disimpulkan bahwa terdapat peningkatan kecerdasan emosi siswa sesudah mengikuti intervensi kecerdasan emosi.
MENURUNKAN KECEMASAN KORBAN KEKERASAN DALAM BERPACARAN DENGAN TEKNIK DESENSITISASI SISTEMATIS (Studi Kasus di Kota Salatiga)
Authors: Aye Sofyan , Wijono Sutarto , Hunga Arianti Ina Restiani 
Published: February 2023

Kecemasan adalah sebuah kegelisahan atau ketakutan pada sesuatu yang bisa dirasakan oleh semua manusia, termasuk perempuan korban kekerasan dalam berpacaran. Perempuan korban kekerasan dalam berpacaran dapat menyebabkan munculnya beberapa perilaku negatif seperti suka melamun, perasaan cemas yang berlebihan, sulit berkonsentrasi, sulit tidur, rasa takut pada laki-laki, dan selalu berprasangka buruk pada sesuatu yang belum mungkin akan terjadi. Penelitian ini bertujuan untuk menjawab permasalahan ini dengan memberikan intervensi teknik desensitisasi sistematis kepada perempuan yang mengalami kecemasan akibat kekerasan dalam pacaran di Kota Salatiga. Metode yang digunakan adalah penelitian kualitatif dengan pendekatan Participatory Action Research. Jumlah partisipan dua orang perempuan korban kekerasan dalam pacaran, yang di peroleh dari focus group discussion. Peneliti juga melakukan pengukuran sebelum dan sesudah intervensi untuk mengetahui efek teknik desensitisasi sistematis. Berdasarkan hasil pengukuran setelah intervensi menunjukan terjadi penurunan tingkat kecemasan pada kedua partisipan. Penurunan tingkat kecemasan bervariasi tergantung masalah dan pemahaman partisipan dalam proses intervensi. Penelitian ini disimpulkan berhasil bahwa intervensi teknik desensitisasi sistematis dapat menurunkan tingkat kecemasan perempuan korban kekerasan dalam pacaran.
Hubungan Antara Keharmonisan Keluarga dengan Konsep Diri Siswa di SMP Negeri Satu Atap Kusuri
Authors: Noya Meidy D. Ar , Pangandaheng Ferderika Selvana 
Published: February 2023

Penelitian ini bertujuan yaitu untuk mengetahui hubungan antara keharmonisan keluarga dengan konsep diri siswa di SMP Negeri Satu Atap Kusuri. Jenis penelitian ini adalah kuantitatif dengan menggunakan pendekatan korelasional. Populasinya adalah seluruh siswa SMP Negeri Satu Atap Kusuri yang berjumlah 267 orang siswa. Metode pengambilan sampel menggunakan teknik probability sampling. Pengumplan data kedua variabel penelitian ini menggunakan angket yang sudah dilakukan pengujian validitas dan reliabilitas.Berdasarkan hasil penelitian yang dilakukan di SMP Negeri Satu Atap Kusuri kepada 100 responden atau sampel diperoleh melalui analisis data uji hipotesis menunjukan bahwa perolehan nilai koefisien korelasi (pearson product moment) sebesar nilai 0,812. Hal ini berarti 0,812 >0,70 menunjukan bahwa tidak ada korelasi atau hubungan yang antara keharmonisan keluarga dengan konsep diri siswa.
Development of new methods for assessing the technical condition of power lines using digital image processing
Authors: Sultanov M. M. , Shamigulov P. V. , Militonyan S. M. , Likhachev A. I. , Brunkov P. N. , Sokolov R. V. , Levin A. A. 
Published: February 2023

An important role in satisfying the high quality of life of the population and modern industry is played by the reliability of power supply and ensuring uninterrupted delivery of electricity. As a result of a large number of emergency failures of elements caused by external factors, information about the technical state of elements in real time is not used by dispatching centers. These conditions cause difficulties in assessing the reliability of power lines and timely elimination of developing defects, which cause high transmission losses and lead to wire breaks and failures.Considering a digital photo or other raster image to assess the surface of power lines wires, we know that it is an array of numbers recorded by sensors of brightness levels, in a two-dimensional plane. Knowing that in mathematical terms a thin lens performs the Fourier transform of images placed in the focal planes, it is possible to create image processing algorithms, which are analogues of image processing by a classical optical system. An algorithm for automatic processing of scanning electron microscopy images aimed at detecting and describing surface defects in power line wires is proposed, which is implemented in the Python programming language. The algorithm proposes to use a Fourier transform procedure to eliminate the image brightness gradient and suppress high-frequency noise in the image by applying a two-dimensional bandpass filter. The necessity and parameters of the dynamic range normalization of the filtered image are determined. The binarization parameters of the normalized image are determined. A quantitative assessment of the degree of defectiveness of the investigated wire surface has been proposed. A quantitative assessment of the degree of elongation of defects on the surface of the investigated wire has been proposed.
DIGITALNI BLIZANCI I SENKE
Authors: Tešić Nemanja 
Published: February 2023

U ovom radu dat je sistematski pregled literature na temu digitalnih blizanaca i senki, razlikama data dva koncepta, oblastima u kojima oni imaju najveću primenu i tehnologijama koji se koriste za njihovu implementaciju. Prikazane su studije koje su se bavile razvojem, unapređenjem i implementacijom digitalnih blizanaca i senki.
Recontextualización del programa “Todos a Aprender” por parte de los docentes de primaria de la I.E. Ricabrisa, Tarqui, Huila
Authors: Vargas Paredes Jessica Milena 
Published: February 2023

Este artículo presenta los resultados del estudio sobre los sentidos de la recontextualización del Programa “Todos a Aprender”, por parte de los docentes de las sedes rurales de primaria de la I.E. Ricabrisa del municipio de Tarqui (Huila). El estudio fue de carácter cualitativo, de tipo fenomenológico-crítico. La información fue recolectada a través de la observación participante, de la formación situada de maestros y la aplicación de entrevistas semiestructuradas de manera personal a docentes, tutores y formador del PTA; también se realizó el análisis documental relacionado con la información referente al Programa “Todos a Aprender” para comprender el discurso pedagógico y su recontextualización.
Tras realizar la investigación, se reconoció el sentido de los maestros frente a la implementación del PTA, teniendo en cuenta las características del aula multigrado; se encontró que estos tienden a participar en diversos programas, en este caso el PTA para fortalecer sus prácticas pedagógicas. De acuerdo con esto, los maestros centraron la atención en los intereses de los estudiantes, generando una comunicación continua y valorando sus saberes. De esta manera, la metodología y el discurso de enseñanza del PTA fueron reestructurados a través de la recontextualización, teniendo en cuenta que los docentes exploraron diversas maneras de formar a los estudiantes a través de la reflexión continua expresada en la comunidad de aprendizaje. Todo este proceso hizo que surgieran identidades pedagógicas en el proceso de recontextualización.