bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can a bulky glycocalyx promote catch bonding in early integrin adhesion? Perhaps a bit
Authors: Blanchard Aaron 
Published: April 2023

Abstract
Many types of cancer overexpress bulky glycoproteins to form a thick glycocalyx layer. The glycocalyx physically separates the cell from its surroundings, but recent work has shown that the glycocalyx can paradoxically increase adhesion to soft tissues and therefore promote the metastasis of cancer cells. This surprising phenomenon occurs because the glycocalyx forces adhesion molecules (called integrins) on the cell’s surface into clusters. These integrin clusters have cooperative effects that allow them to form stronger adhesions to surrounding tissues than would be possible with equivalent numbers of un-clustered integrins. These cooperative mechanisms have been intensely scrutinized in recent years; a more nuanced understanding of the biophysical underpinnings of glycocalyx-mediated adhesion could uncover therapeutic targets, deepen our general understanding of cancer metastasis, and elucidate general biophysical processes that extend far beyond the realm of cancer research. This work examines the hypothesis that the glycocalyx has the additional effect of increasing mechanical tension experienced by clustered integrins. Integrins function as mechanosensors that undergo catch bonding – meaning the application of moderate tension increases integrin bond lifetime relative to the lifetime of integrins experiencing low tension. In this work, a three-state chemomechanical catch bond model of integrin tension is used to investigate catch bonding in the presence of a bulky glycocalyx. This modeling suggests that a bulky glycocalyx can lightly trigger catch bonding, increasing the bond lifetime of integrins at adhesion edges by up to 100%. The total number of integrin-ligand bonds within an adhesion is predicted to increase by up to ~ 60% for certain adhesion geometries. Catch bonding is predicted to decrease the activation energy of adhesion formation by ~ 1–4 kBT, which translates to a ~ 3–50× increase in the kinetic rate of adhesion nucleation. This work reveals that integrin mechanic and clustering likely both contribute to glycocalyx-mediated metastasis.
Flexible surface-enhanced Raman scattering strips using colloidal ink of gold- silver alloyed nanoparticles
Authors: Tian Honghao , Qin Youjian , Liu Hongmei , Li Tian , Li Yuting , Fang Xiaohui , Zhang Xinping 
Published: April 2023

Abstract
Surface-enhanced Raman scattering (SERS) has been used for trace detection at the single-molecule level. The low-cost preparation of high-performance test strips has enabled the development of SERS techniques. In this study, oil-dispersible metal or alloy nanoparticles prepared by the Brust-Schiffrin method were used as "inks" in a ballpoint pen to handwrite SERS test strips on polytetrafluoroethylene (PTFE) membranes. Because of the good PTFE lipophilicity, the flexible substrates had good uniformity. The large laser damage threshold of the PTFE membrane also enabled increased laser powers for SERS testing. The Au and Ag alloy nanoparticle inks exhibited increased performance with larger proportions of Ag. The Au1Ag8 nanoparticles had the best properties, and those strips could detect 10-11-M Rhodamine 6G dyes in a 5-µL volume with an enhancement factor of 5.4×108. The SERS strips were used to demonstrate detection of malachite green, the use of which is prohibited in aquaculture and fish tanks.
Synthesis Cobalt Complexed Single Chain Polymer and its Nanographene-based Composites, Electrical, Optical, and Thermal properties
Authors: Zebari Osama Ismail Haji , DEMİRELLİ Kadir , Zeebaree Samie Yaseen Sharaf , Tuncer Hülya 
Published: April 2023

Abstract
Atom transfer radical polymerization (ATRP) technique was used in the preparation of Poly [4-((4-vinylbenzyl)oxy) phthalonitrile-co-methyl methacrylate] P(VBOPN 13.4%- co-MMA) at a temperature of 110oC. Single chain polymer complexed cobalt phthalocyanine (SCP-CoPc) have been synthesized via cyclotautomerization approach using aforementioned copolymer caring VBOPN pendant group to form green colored single chain folded polymer molecule at a high range of temperature 140-150oC and high dilution condition of cyclohexanol solvent. The formation of cobalt atom collapsed via intramolecular forces into single chain polymer was characterized by Fourier-transform infrared spectroscopy and UV/Vis spectroscopy and shows high solubility in most organic solvents. The thermal of SCP-CoPc and nanogaphene-based SCP-CoPc/NG 6 wt% nanocomposite as well as electrical, dielectric, and optical properties of both materials were investigated. SCP-CoPc/NG 6 wt% nanocomposite was observed to have temperature-dependent increases in dielectric and dc. electrical conductivity. The activation energy, Ea was found to be 0.295 eV for the I. region and 0.39 eV for the II region, demonstrating that the conduction followed the Arrhenius equation. Estimates were made regarding the optical constants of SCP-CoPc/NG 6 wt%, specifically the refractive index, the real value of the optical dielectric constant, and the optical band gap. Both the direct band gap and the refractive index of SCP-CoPc and SCP-CoPc/NG 6 wt% were calculated, and the direct band gap of SCP-CoPc was calculated to be 2.83 eV, while the direct band gap of SCP-CoPc/NG 6 wt% was calculated to be 2.58 eV.
Efficacy of the peritoneovenous shunt as palliative care for cancer patients with refractory ascites: a randomized controlled trial (JIVROSG-0803 study)
Authors: Arai Yasuaki , Sone Miyuki , Takeuchi Yoshito , Sugawara Shunsuke , Aramaki Takeshi , Tanaka Toshihiro , Sato Mikio , Morita Shinichi 
Published: April 2023

Abstract
Background
A randomized, controlled trial to evaluate the superiority of peritoneovenous shunt (PVS) over the other treatments for refractory ascites in advanced cancer patient was conducted.
Subjects and methods
The subjects were advanced cancer patients with symptoms due to refractory ascites which are difficult to control by medical therapy and cannot be improved by methods other than drainage and with a Palliative Prognostic Index of <6. They were randomly allocated in a 1:1 ratio to receive either PVS placement (test group) or the other treatment (control group). The area under the curve (AUC) of symptom improvement score curve calculated with visual analog scale was compared between the groups as the primary endpoint. The AUC of EQ-5D, SF-8 were also compared between the groups, and adverse events were evaluated with the CTCAE version 3 up to 4 weeks after enrollment or until protocol treatment was discontinued.
Results
Forty patients were enrolled between November 2009 and July 2018, with 20 allocated to test group and 20 control group. The mean AUC of the symptom improvement score curves were 133.2 (95% CI: 98.6-167.7) in the test group and 69.9 (95% CI: 34.4-105.4) in the control group (p=0.014). Therefore, the mean AUC was significantly larger in the test group, resulting the primary endpoint was met. There was no significant difference between the groups in SF-8 and EQ-5D. Though some known adverse events were observed, there was no significant difference in the frequency of individual adverse events between the groups.
Conclusions
PVS significantly improves the symptom of pain due to refractory ascites compared to other treatments. Although not as effective as improving the comprehensive QOL evaluated with SF-8 and EQ-5D, PVS may be considered the standard of care for advanced cancer patients with refractory ascites.
Clinical value of circulating tumor cells and hematological parameters in 617 Chinese patients with colorectal cancer: Retrospective analysis
Authors: He Yuhao , He Xinxin , Zhou Yubo , Luo Shanshan 
Published: April 2023

Abstract
Background:Circulating tumor cells (CTCs) was a popular non-invasive liquid biopsy technique in recent years. The purpose of this study was to investigate the relationship between circulating tumor cells and colorectal cancer.
Methods: The clinical data of 617 patients with colorectal cancer from October 2019 to March 2022 were retrospectively collected to analyze the correlation between CTCs and clinicopathologic characteristics.
Results: The CTCs value increased with the progression of T stage, M stage and TNM stage (P < 0.05), but had no correlation with N stage (P > 0.05). Binary logistic regression analysis showed that CTCs, CEA, CA125 and CA199 were independent risk factors for distant CRC metastasis. Compared with CTCs, CEA, CA125 and CA199, the Logistic model had the highest AUC (AUC=0.778,95%CI: 0.732-0.824), and the specificity and sensitivity were 82.9% and 63.2%, respectively. After operation, chemoradiotherapy and other treatment for CRC, CTCs and CEA were significantly decreased compared with before treatment (P < 0.05). In addition, Spearman Correlation showed significant correlation between CTCs and IgG (P=0.000).
Conclusion: CTCs was closely related to the stage of colorectal cancer, the prediction of distant organ metastasis, and the evaluation of therapeutic effect, which is helpful for clinical decision-making.
Healthcare provider experiences interacting with survivors of intimate partner violence: A qualitative study to inform survivor-centered approaches
Authors: Anguzu Ronald , Cassidy Laura D. , Nakimuli Annettee O. , Kansiime Judith , Babikako Harriet M. , Beyer Kirsten M.M. , Walker Rebekah J. , Wandira Christopher , Kizito Felix , Dickson-Gomez Julia 
Published: April 2023

Abstract
Background: Intimate partner violence (IPV) remains a pervasive form of gender-based violence (GBV) that is largely undisclosed, especially among women seeking healthcare services in Uganda. Prioritizing survivor needs, preferences, and rights may improve IPV disclosure. This study explores healthcare worker experiences from provider-patient interactions with survivors seeking antenatal care services (ANC) in Uganda.
Methods: In-depth interviews were conducted among twenty-eight experienced healthcare providers in a rural and an urban-based ANC clinic in Eastern and Central Uganda. Providers were asked what they viewed as the needs and fears of women identified as having experienced any form of IPV. Iterative, inductive/deductive thematic analysis was conducted to discover themes regarding perceived needs, fears, and underlying contextual issues experienced by IPV survivors.
Results: According to healthcare providers, IPV survivors are unaware of available support services, and need economic empowerment. Providers reported that some survivors were concerned for their personal safety, and the consequences of IPV disclosure including community stigma, retaliatory abuse, marriage loss, and losing partners’ financial support. Women survivors also blamed themselves for IPV. Contextual factors underlying survivor concerns included the socio-economic environment, namely, social, and cultural norms condoning violence, household poverty, and survivors’ unawareness of their human rights.
Conclusions: We underscore a need to empower IPV survivors by prioritizing their needs, preferences, and rights. Results highlight opportunities to create a conducive healthcare environment that fosters IPV disclosure while addressing survivors’ immediate medical and psychosocial needs, and safety concerns. Re-framing GBV prevention and response programming strategies in Uganda towards survivor-centered approaches is recommended.
Preparation 2-Hydroxy-1-naphthaldehyde cross-linked magnetic Fe3O4@chitosan- polyacrylamide nanocomposite for removal of everzol black from aqueous solutions
Authors: Saadat Afshin , Banaei Alireza , Sattarifar Mehdi , Ghasemi Parinaz Pargol 
Published: April 2023

Abstract
In this study, new 2-Hydroxy-1-naphthaldehyde linked magnetic Fe3O4/chitosan-polyacrylamide nanoparticles were prepared. The synthesized nanoparticles were characterized by (FT- IR), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), vibrating Sample Magnetometry (VSM) and Termogravimetric Analysis (TGA). The 2-Hydroxy-1-naphthaldehyde modified magnetic Fe3O4/chitosan-polyacrylamide nanoparticles were used as an effective adsorbent for removal of Everzol black from aqueous solutions by batch adsorption procedure. The effects of important parameters on the surface absorption process of Everzol black dye, including pH, contact time, adsorbent dosage and initial dye concentration were studied. The Langmuir and Freundlich adsorption models were used to describe adsorption isotherms and constants.
Evaluation of retinal vascularization in retinopathy of prematurity regressed after intravitreal ranibizumab monotherapy or without treatment based on fluorescein angiography
Authors: Wu Lei , Li Manhong , Wang Liang , Yan Hongxiang , Zhou Ziyi , Fan Jing , Zhou Yi , Gou Kaili , Guo Changmei , Wang Yusheng , Zhang Zifeng 
Published: April 2023

Abstract
To investigate the fluorescein angiography (FA) findings and compare the extent of retinal vascularization in retinopathy of prematurity (ROP), recovered after intravitreal ranibizumab (IVR) monotherapy and those regressed spontaneously. Infants with a history of ROP who underwent FA between April 2018 and November 2021 were retrospectively included. The patients were divided into two groups based on whether they had received IVR or had ROP that regressed spontaneously without treatment. The differences between the two groups in zone Ⅱ ROP were also compared, to equalize the subgroups as much as possible in terms of disease severity. FA findings were recorded. The extent of vascularization was measured by the ratio of the distance from the center of the disk to the border of the vascularized zone (DB) and the distance from the center of the disk to the center of the fovea (DF). The width of the persistent avascular retina (PAR) was counted by disc diameters (DD). One hundred and ten eyes of 55 infants were included in the IVR group and 76 eyes of 38 babies in the untreated group. The ratio of abnormal shape of vessels was significantly higher in the IVR group than in the untreated group (50.9% v.s. 35.5%; P = 0.038), while the linear choroidal filling pattern, tortuosity of vessels over the posterior pole, dye leakage, anomalous branching of vessels, circumferential vessels, arteriovenous shunt, abnormal capillary bed, and macular abnormalities were similarly. There was a smaller temporal DB/DF ratio (4.48 v.s. 4.63; P = 0.003) and greater PAR (2.63 v.s. 1.76; P < 0.001) in the IVR group compared to the untreated group. In zone Ⅱ ROP, the progression of retinal vascularization was significantly larger in the IVR group than that in the untreated group (P = 0.003), while no statistical differences were observed in FA features, the DB/DF ratio, and PAR between the two subgroups. The residual vascular abnormalities and PAR may be common results of ROP regression. The DB/DF ratio of 4.0 temporally and 3.3 nasally could be used as the preliminary indicators for safe retinal vascularization in the completion of ROP regression.
Enhanced performance of nanocomposite membrane developed on sulfonated poly (1, 4-phenylene ether-ether-sulfone) with zeolite imidazole frameworks for fuel cell application
Authors: Soleomani Bita , Asl Ali Haghighi , Khoshandam Behnam , Hooshyari Khadije 
Published: April 2023

Abstract
Proton exchange membrane fuel cells have received a lot of interest and use metal organic frameworks (MOF)/polymer nanocomposite membranes (PEMFC). ZIF-90 was employed as an addition in the SPEES matrix in order to investigate the proton conductivity in a novel nanocomposite membrane made of sulfonated poly (1, 4-phenylene ether-ether-sulfone) (SPEES)/zeolite imidazole framework (ZIF). The high porosity, free surface, and presence of the aldehyde group in the ZIF-90 nanostructure have a substantial impact on enhancing the mechanical, chemical, thermal, and proton conductivity capabilities of the SPEES/ZIF-90 nanocomposite membranes. The findings demonstrate that SPEES/ZIF-90 nanocomposite membranes with 3 wt. % ZIF-90 had proton conductivities up to 160 mS/cm at 90°C and 98% RH, which was 1.9 times more than SPEES membrane at 55 mS/cm under the same conditions. In comparison to the pristine SPEES membrane, the SPEES/ZIF-90/3 membrane demonstrated a 79 percent increase in maximum power density (0.52 W/cm2 at 0.5 V and 98% RH).
Identification of coastal natural disasters using official databases to provide support for the coastal management: the case of Santa Catarina, Brazil
Authors: Leal Karine Bastos , Robaina Luís Eduardo de Souza , Körting Thales Sehn , Nicolodi João Luiz , Costa Júlia Dasso da , Souza Vitória Gonçalves 
Published: April 2023

Abstract
The increase in natural disaster frequency, intensified by climate change, represents one of the greatest threats to coastal systems and low-lying areas around the world. It is estimated that the Global Mean Sea Level (GMSL) could rise by approximately 2 m in the 21st century, in addition to intensifying cyclonic events. As a result, in Brazil, natural coastal disasters are likely to become more frequent and intense, especially in the southern region. Thus, the main goal of this study is to identify, map and discuss coastal natural disasters that occurred in municipalities exposed to the open ocean belonging to the coastal zone of the state of Santa Catarina, Brazil, between 1998 and 2020. For this, we carried out a review and dating of natural coastal disasters, based on four official databases: The Civil Defense of Santa Catarina website; Integrated Disaster Information System (S2ID); Santa Catarina Atlas of Natural Disasters; and the Brazilian Atlas of Natural Disasters. As results and main conclusions, it was observed that: 1) There were more coastal disasters in the north, central-north, and central sectors of SC between 1998 and 2020; 2) The period between 2010 and 2020 was more impactful; 3) The municipalities with the most records of coastal natural disasters were Balneário Barra do Sul, Itapoá and Florianópolis (considering only Ilha de Santa Catarina), respectively; 4) The three fastest-growing sectors are the north, central-north, and central; and 5) The seasons of autumn, spring, and winter, respectively, are more impacting for the coast of SC.
Eye state recognition based on continuous wavelet transform and improved convolutional neural network
Authors: Xiao Qiyang , Yang Maolin , Yuan Ke 
Published: April 2023

Abstract
EEG signals are multi-dimensional and non-stationary time series signals, and their features are not easy to extract, so large deviations are often encountered in the classification and prediction tasks. Therefore, in this paper, an EEG eye state (open or close) recognition method is proposed based on an improved convolutional neural network and the continuous wavelet transform. First, for the high noise levels encountered during EEG signal acquisition, variational mode decomposition (VMD) is used to decompose the EEG signal into several modal components, which are then subsequently used to reconstruct the signal according to the correlation principle to obtain a noiseless signal. Secondly, the continuous wavelet transform (CWT) method is used to extract the features of the EEG signals in the time and frequency domains, and the one-dimensional signal is converted into two-dimensional images to enhance the feature-learning ability convolutional networks. Finally, a residual term is introduced on the basis of the traditional convolutional neural network, and a recognition model is constructed by combining a dual channel and spatial attention mechanism. Experimental results show that the proposed model has an accuracy rate higher than 99\%, and is more effective and with better generalizability than previous studies.
Statistical learning models to measure the impact of ESG factors on credit ratings
Authors: Agosto Arianna , Cerchiello Paola , Giudici Paolo 
Published: April 2023

Abstract
Artificial Intelligence methods, based on either statistical or machine learning models, are rapidly changing financial services, credit lending in particular, complementing traditional bank lending with platform lending.While financial technologies improve user experience, and possibly lower costs, they may increase risks and, in particular, the model risks that derive from inaccurate credit rating assessments.In this paper we will show how to reduce model risks, using a S.A.F.E. statistical learning model, which means improving: Sustainability, by taking environmental, social and governance factors into account; Accuracy, by building a model for which ESG factors do predict credit ratings; Fairness, by dealing with data inconsistencies; Explainability, by merging ESG scores into one measure.
Changes in Aridity and Its Impact on Agricultural Lands in East Asia for 1.5 and 2.0°C Temperature Rise Scenarios
Authors: Ziarh Ghaith Falah , Chung Eun Sung , Hamed Mohammed Magdy , Hassan Maan S. , Shahid Shamsuddin 
Published: April 2023

Abstract
This study aimed to assess the changes in aridity in East Asia (EA) over the next 80 years for the restriction of global warming based on Paris agreement goals. Eight General Circulation Models (GCMs) that provide simulations for 1.5 and 2.0°C global warming scenarios were used for this purpose. The Penman-Monteith Equation was utilized to calculate potential evapotranspiration (PET). The land-use projections data was used to identify the agricultural lands that aridity could impact. The results showed a likely increase in rainfall and PET in EA over the next 80 years. However, the spatial variability of the relative increase in rainfall and PET would cause an aridity shift in 1.2−9.7% of the total land area. Though most of the area would experience a transition to a wetter climate, nearly 2% of the land would experience a transition to a drier climate. It would cause nearly 4.4 and 6.2 thousand km2 of agricultural land to be converted from semi-arid to arid and 31.1 and 42.2 thousand km2 of land from sub-humid to semi-arid in the early period for 1.5 and 2.0°C temperature rise scenarios, respectively. This indicates nearly one and a half times more expansion of aridity on agricultural land in the early period for only a 0.5°C increase in temperature. A decrease in aridity in the far future for both scenarios would cause a reduction of total arid lands and, thus, its impacts on agriculture. Overall, the study revealed a possible reduction of aridity in EA in the long run if the Paris agreement is enforced and global warming is limited.
Resource recovery and reduction of tidal waste through clean processes to obtain cellulose
Authors: Moral Ana , Greyer Valeria , Aguado Roberto , Tijero Antonio 
Published: April 2023

Abstract
The transition towards a sustainable cellulose industry needs more environmentally friendly technologies that include the use of less polluting processes and alternative raw materials. This work shows the potential of tidal waste from the Andalusian Mediterranean coastline as cellulosic material to obtain cellulosic pulp. With this purpose, predominant species in onshore residues (mainly Posidonia oceanica) were prepared, characterized, and subjected to a soda-anthraquinone pulping process. A central composite design was defined in order to relate the process conditions to the composition and characteristics of the cellulose pulp. It was concluded that polynomial models encompassing linear, quadratic, and binary effect parameters reproduce the experimental results satisfactorily. Results allowed to choose high anthraquinone concentration, soda concentration and temperature (1%, 30% and 150 ºC, respectively), low liquid/solid ratio (4) and short time (30 min) as a compromise solution, by which the brightness, ethanol-benzene extractives content, kappa index, lignin content and viscosity were near their optimal. Low values of liquid/solid ratio reduce water consumption, which is of utmost importance in cellulose industries likewise short time treatments to saves energy.