bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elucidating the impact of biochar with different carbon/nitrogen ratios on soil biochemical properties and rhizosphere bacterial communities of flue-cured tobacco plants
Authors: Yang Yingfen , Ye Chenghu , Zhang Wei , Zhu Xiaohong , Li Haohao , Yang Dehai , Ahmed Waqar , Zhao Zhengxiong 
Published: September 2023

Background and aimsIn agriculture, biochar (BC) and nitrogen (N) fertilizers are commonly used for improving soil fertility and crop productivity. However, it remains unclear how different levels of BC and N fertilizer affect soil fertility and crop productivity.MethodsThis study elucidates the impact of different application rates of BC (0, 600, and 1200 kg/ha) and N fertilizer (105 and 126 kg/ha) on biomass accumulation, soil microbial biomass of carbon (SMC) and nitrogen (SMN), and soil biochemical properties, including soil organic carbon (SOC), total nitrogen (TN), soil nitrate nitrogen (NO3−−N), ammonium nitrogen (NH4+−N), urease (UE), acid phosphatase (ACP), catalase (CAT), and sucrase (SC) of tobacco plants. In addition, a high throughput amplicon sequencing technique was adopted to investigate the effect of different application rates of BC/N on rhizosphere bacterial communities of tobacco plants.ResultsThe results confirm that high dosages of BC and N fertilizer (B1200N126) significantly enhance dry matter accumulation by 31.56% and 23.97% compared with control B0N105 and B0N126 under field conditions and 23.94% and 24.52% under pot experiment, respectively. The soil biochemical properties, SMC, and SMN significantly improved under the high application rate of BC and N fertilizer (B1200N126), while it negatively influenced the soil carbon/nitrogen ratio. Analysis of rhizosphere bacteriome through amplicon sequencing of 16S rRNA revealed that the structure, diversity, and composition of rhizosphere bacterial communities dramatically changed under different BC/N ratios. Proteobacteria, Bacteroidetes, Actinobacteria, Firmicutes, and Acidobacteria were highly abundant bacterial phyla in the rhizosphere of tobacco plants under different treatments. Co-occurrence network analysis displayed fewer negative correlations among rhizosphere bacterial communities under high dosages of biochar and nitrogen (B1200N126) than other treatments, which showed less competition for resources among microbes. In addition, a redundancy analysis further proved a significant positive correlation among SMC, SMN, soil biochemical properties, and high dosage of biochar and nitrogen (B1200N126).ConclusionsThus, we conclude that a high dosage of BC (1200 kg/ha) under a high application rate of N fertilizer (126 kg/ha) enhances the biomass accumulation of tobacco plants by improving the soil biochemical properties and activities of rhizosphere bacterial communities.
Exploring the effects of physical exercise on inferiority feeling in children and adolescents with disabilities: a test of chain mediated effects of self-depletion and self-efficacy
Authors: Yang Tongnian , Xiao Hui , Fan Xiaoyan , Zeng Wenping 
Published: September 2023

ObjectiveThe purpose of this study was to investigate the effects of physical exercise on inferiority feeling of children and adolescents with disabilities and its mechanism of action, as well as the mediating role of self depletion and self-efficacy.MethodsThe following scales were administered to 546 children and adolescents with disabilities (mean age 15.6 years): The Feelings of Inadequacy Scale, (FIS), the Self-Regulation Fatigue Scale (S-RFS), the General Self-Efficacy Scale (GSES), and the Physical Exercise Rating Scale.Results(1) Physical exercise can directly and negatively predict inferiority feeling, self-depletion, and can directly and positively predict self-efficacy; self-depletion can directly and negatively predict self-efficacy. Similarly, self-depletion positively predicts inferiority feeling; physical exercise and self-efficacy can also directly and negatively predict inferiority feeling. (2) The indirect effect of the path with self-depletion as the mediating variable was – 0.05, the indirect effect of the path with self-efficacy as the mediating variable was – 0.09, and the indirect effect of the path with self-depletion and self-efficacy as the mediating variables was – 0.04. (3) The sum of all indirect effects was – 0.18, and the three indirect effects accounted for 15.6%, 28.1%, and 12.5% of the total effect, with mediating effect was 56.2%.ConclusionPhysical exercise can indirectly predict inferiority feeling in children and adolescents with disabilities through the independent mediation of self-depletion and self-efficacy, as well as through the chain mediation of both. This study supports that moderate physical exercise has a positive effect on the mental health of children and adolescents with disabilities, and that reducing self-depletion and improving self-efficacy are important ways to prevent inferiority feeling among children and adolescents with disabilities. It reveals the relationship between physical exercise and inferiority feeling and its mechanism of action, and further improves the research on the effect of physical exercise on inferiority feeling of children and adolescents with disabilities.
Prevalence and factors influencing cognitive impairment among the older adult stroke survivors: a cross-sectional study
Authors: Huang Yanjin , Wang Qi , Zou Ping , He Guoping , Zeng Ying , Yang Jing 
Published: September 2023

BackgroundCognitive impairment as a complication in post-stroke patients has high prevalence throughout the world. However, few studies have focused on the older adult stroke survivors and explored their prevalence and factors of post-stroke cognitive impairment (PSCI). The study aims to evaluate the cognitive status of stroke patients in Hunan Province, China and to determine the potential risk factors associated with PSCI in order to identify the older adult population in advance and promote healthy aging.MethodsThis cross-sectional study was carried out from August to December, 2021. A total of 520 stroke survivors from 6 tertiary hospitals were randomly selected. The information was collected using the general questionnaire, the Barthel Index Rating Scale and the Mini-mental State Examination (MMSE). Analysis was based on descriptive statistics, chi-square test and the significant variables were included in multivariate logistic regression. The reporting of this cross-sectional study followed the STROBE checklist.ResultsA total of 195 older adults (40.37%) were screened for cognitive impairment based on the results of the MMSE score. Patients in the PSCI group had a higher proportion of individuals aged 70 or older (35.90% vs. 24.65%, p&lt;0.001). The potential risk factors for post-stroke cognitive impairment in older adults were being aged between 70 and 79 years old (OR = 3.973, 95% CI, 2.346–6.729, p&lt;0.001), being aged 80 years or older (OR = 3.590, 95% CI, 1.373–9.387, p = 0.009), having a low level of education (OR = 9.183, 95% CI, 5.341–15.789, p&lt;0.001), having hypertension (OR = 1.756, 95% CI, 1.121–2.753, p = 0.014), and having a dominant hemisphere lesion (OR = 1.880, 95% CI, 1.193–2.962, p&lt;0.001).ConclusionThe prevalence of PSCI was high among Chinese older adults, particularly those aged 80 years or older. The factors identified in our study could assist in the early identification of older adults at risk, develop personalized management plans, and promote healthy aging.
Comparison of oral cavity protein abundance among caries-free and caries-affected individuals—a systematic review and meta-analysis
Authors: Silveira Eliane Garcia da , Prato Laura Schaurich , Pilati Sarah Freygang Mendes , Arthur Rodrigo Alex 
Published: September 2023

ObjectiveSome salivary proteins seem to be differently abundant among caries-free (CF) and caries-affected (CA) individuals, but previous results are contradictory precluding that definitive conclusion be drawn. A pooled analysis of the available evidence may provide more robust data on identifying oral cavity protein patterns among CF and CA individuals. This systematic review and meta-analysis (PROSPERO CRD42021269079) aimed to compare the oral cavity protein abundance among caries-free and caries-affected individuals.MethodsThis study was conducted following PRISMA guidelines. PubMed, Embase, and Web of Science databases were systematically assessed (up to February 2023) to retrieve clinical studies written in English, German, or in Latin-based languages that compared the oral cavity protein abundance among CF and CA individuals. Data extraction and methodological quality assessment (NIH guidelines) were independently performed by two investigators. Qualitative synthesis was performed from all included studies and meta-analysis was performed using a random-effects model with inverse variance for studies that reported the concentration of proteins or enzymatic activity. Standardized mean difference (SMD) with respective 95% confidence interval (CI) were calculated for each outcome.ResultsA total of 90 studies (two cohort and 88 cross-sectional designs) of more than 6,000 participants were selected for data extraction, being the quality of evidence graded as “fair” for most of them. The oral cavity of CF individuals presented lower total protein concentration [SMD = 0.37 (95% CI: 0.07–0.68; 18 studies)], lower total antioxidant capacity [SMD = 1.29 (95% CI: 0.74–1.85); 17 studies], and lower carbonic anhydrase activity [SMD = 0.83 (95% CI: 0.58–1.09); three studies], whereas CA individuals presented lower carbonic anhydrase concentration [SMD = −0.66 (95% CI: −1.00 to −0.32); three studies], urease [SMD = −0.95 (IC 95%: −1.72 to −0.17); four studies], and arginine deiminase system [SMD = −2.07 (95% CI: −3.53 to −0.62); three studies] activities. Antimicrobial peptides, secretory immunoglobulin-A concentrations and alpha-amylase activity were similar among individuals.ConclusionDifferences on oral cavity protein abundance were observed among CF and CA individuals. These data indicate some protein patterns for the oral health and dental caries conditions. Even when statistically significant, some of the results were not very consistent. Cohort studies need to be conducted to validate these results.
Two Novel Iboga-Type and an Oxindole Glucuronide Alkaloid from Tabernaemontana peduncularis Disclose Related Biosynthetic Pathways to Tabernaemontana divaricata
Authors: Traxler Florian , Zhang Haoqi , Mahavorasirikul Wiratchanee , Krivanek Katharina , Cai Xiang-Hai , Aiyakool Wichai , Pfeiffer Martin , Brecker Lothar , Schinnerl Johann 
Published: September 2023

Phytochemical investigation of the two Tabernaemontana species (Apocynaceae) T. peduncularis Wall. and T. divaricata (L.) R.Br. ex Roem. & Schult. indicated closely related biosynthetic pathways leading to lipophilic and hydrophilic alkaloids. In total, 18 specialized metabolites comprising indole-derived alkaloid aglycones, three oxindole-derived alkaloid glycosides, and two iridoid glucosides could be identified in the studied species. Among the alkaloids, the two Iboga-type alkaloids 3,7-coronaridine isoindolenine, coronaridine 3,4-iminium and a javaniside derivative bearing a glucuronic acid, named javanuronic acid, could be described by spectroscopic and spectrometric methods for the first time. A docking experiment using alpha-fold was performed to generate a protein model of the enzyme 7-deoxyloganetic acid glucosyl transferase. Performed bioassays exhibited a growth reduction of neonate Spodoptera littoralis larvae and reduced cell viability of HepG2 cells of the extracts containing Iboga alkaloids, whilst the javaniside derivatives containing hydrophilic fraction did not show any effects. These findings indicate a high flexibility in the formation of bioactive indole alkaloid aglycones by Tabernaemontana species and also evidence similar accumulation trends in both species as well as indicate that biosynthetic routes leading to oxindole alkaloids like javanisides are more widespread than reported. Furthermore, the incorporation of the three novel compounds into potential biosynthetic pathways is discussed.
Molecular Docking and Molecular Dynamics Studies Reveal the Anticancer Potential of Medicinal-Plant-Derived Lignans as MDM2-P53 Interaction Inhibitors
Authors: Shoaib Tagyedeen H. , Abdelmoniem Nihal , Mukhtar Rua M. , Alqhtani Amal Th. , Alalawi Abdullah L. , Alawaji Razan , Althubyani Mashael S. , Mohamed Shaimaa G. A. , Mohamed Gamal A. , Ibrahim Sabrin R. M. , Hussein Hazem G. A. , Alzain Abdulrahim A. 
Published: September 2023

The interaction between the tumor suppressor protein p53 and its negative regulator, the MDM2 oncogenic protein, has gained significant attention in cancer drug discovery. In this study, 120 lignans reported from Ferula sinkiangensis and Justicia procumbens were assessed for docking simulations on the active pocket of the MDM2 crystal structure bound to Nutlin-3a. The docking analysis identified nine compounds with higher docking scores than the co-crystallized reference. Subsequent AMDET profiling revealed satisfactory pharmacokinetic and safety parameters for these natural products. Three compounds, namely, justin A, 6-hydroxy justicidin A, and 6′-hydroxy justicidin B, were selected for further investigation due to their strong binding affinities of −7.526 kcal/mol, −7.438 kcal/mol, and −7.240 kcal/mol, respectively, which surpassed the binding affinity of the reference inhibitor Nutlin-3a (−6.830 kcal/mol). To assess the stability and reliability of the binding of the candidate hits, a molecular dynamics simulation was performed over a duration of 100 ns. Remarkably, the thorough analysis demonstrated that all the hits exhibited stable molecular dynamics profiles. Based on their effective binding to MDM2, favorable pharmacokinetic properties, and molecular dynamics behavior, these compounds represent a promising starting point for further refinement. Nevertheless, it is essential to synthesize the suggested compounds and evaluate their activity through in vitro and in vivo experiments.
Fast and Uncooled Semiconducting Ca-Doped Y-Ba-Cu-O Thin Film-Based Thermal Sensors for Infrared
Authors: Dégardin Annick , Alamarguy David , Brézard Oudot Aurore , Beldi Samir , Chaumont Christine , Boussaha Faouzi , Cheneau Antoine , Kreisler Alain 
Published: September 2023

YBa2Cu3O6+x (YBCO) cuprates are semiconductive when oxygen depleted (x < 0.5). They can be used for uncooled thermal detection in the near-infrared: (i) low temperature deposition on silicon substrates, leading to an amorphous phase (a-YBCO); (ii) pyroelectric properties exploited in thermal detectors offering both low noise and fast response above 1 MHz. However, a-YBCO films exhibit a small direct current (DC) electrical conductivity, with strong non-linearity of current–voltage plots. Calcium doping is well known for improving the transport properties of oxygen-rich YBCO films (x > 0.7). In this paper, we consider the performances of pyroelectric detectors made from calcium-doped (10 at. %) and undoped a-YBCO films. First, the surface microstructure, composition, and DC electrical properties of a-Y0.9Ca0.1Ba2Cu3O6+x films were investigated; then devices were tested at 850 nm wavelength and results were analyzed with an analytical model. A lower DC conductivity was measured for the calcium-doped material, which exhibited a slightly rougher surface, with copper-rich precipitates. The calcium-doped device exhibited a higher specific detectivity (D*=7.5×107 cm·Hz/W at 100 kHz) than the undoped device. Moreover, a shorter thermal time constant (<8 ns) was inferred as compared to the undoped device and commercially available pyroelectric sensors, thus paving the way to significant improvements for fast infrared imaging applications.
ANALISIS FUNGSI PRODUKSI COBB-DOUGLAS PADA USAHATANI SAYUR KUBIS (Brassica Oleracea Var. Capitata L.) DI DESA NETPALA KECAMATAN MOLLO UTARA KABUPATEN TIMOR TENGAH SELATAN
Authors: Teftae Nenda , Pellokila Marthen Robinson , Levis Leta Rafael 
Published: September 2023

This study aimed to find out the; 1) Conditions of return to scale cabbage vegetable farming, 2) The farmers’ income earning by selling cabbage in Netpala village, Mollo Utara sub- district of Timor Tengah Selatan regency. Netpala village was chosen as the location of the study using purposive sampling technique. Data collection was conducted in August 2019 and data was statisticaly descriptive analysis. The measured variable were the condition of retr’n to scale cabbage vegetable farming, and the amount of cabbage vegetable farming income (Rp).
The results showed that 1) Cabbage vegetable farming in Netpala Village when viewed from the scale of results was in a condition of decreasing Return to Scale α + β <1 means that the proportion of the addition of production factors will produce additional production with a smaller proportion. The analysis shows that the parameters b + c + d + e = 0.960 are smaller than 1. This means that the proportion of the addition of production factors (inputs) in this case X1 (land area), X2 (seeds), X3 (fertilizer), X4 (power work) proportionally by 1% will result in an increase in Y (cabbage production) by 0.960%. 2) Cabbage vegetable farmers’ income in study site was Rp. 637,649,582 with the average income earned by the respondent amounting to Rp.12,031,124.
EFEKTIVITAS KINERJA MANAJEMEN BADAN USAHA MILIK DESA “MOINFEU” DESA OELBITENO KECAMATAN FATULEU TENGAH KABUPATEN KUPANG
Authors: Rasak Laurensius , Kapioru Charles , Un Paulus 
Published: September 2023

This research was conducted at Badan Usaha Milik Desa Moinfeu, Oelbiteno village, middle Fatuleu Sub district, Kupang Regency. The purpose os this study was to know about the application of manajemen principles and how much that gained by Badan Usaha Milik Desa Moinfeu business units, Oelbiteno Village middle Fatuleu Sub district, Kupang Regency. This study used a qualitative descriptive analysis, that interpreting the object as what it is. The results of this study snowed that Badan Usaha Milik Desa Moinfeu business units, Oelbiteno Village middle Fatuleu Sub district, Kupang Regency had not maximally yet on applied the managemant principles, which is the planning principle, and there was no employment contract that hind to members and there was no clear recruitment criterias for the employees. Due to the organitation’s principles, there was overlapping of work and about the leader’s principles, there was no leader,s role on managing Badan Usaha Milik Desa Moinfeu and about the principle of supervisory management, there were no indicators in conducting supervision. The results showed that the amountof acceptance of the agency has clear employee recruitment criteria, about the principleof organizing the Badan Usaha Milik Desa Moinfeu, they received IDR 8,000,000 in 2019. This revenue is divided based on Peraturan Desa Oelbiteno No. 6 of 2017 about the establishment of Badan Usaha Milik Desa on paragraph 29. Based on this division, the amount of income of is Rp.2,000,000 (25%), that is for raising invesment for Badan Usaha Milik Desa Moinfeu.
PERSEPSI PETANI TERHADAP PERANAN KELOMPOK TANI BAWANG MERAH (ALLIUM ASCALONICUM L) DI DESA TUNGANAMO KECAMATAN PANTAI BARU
Authors: Tenu Yumisa , Nikolaus Serman , Nampa I Wayan 
Published: September 2023

This research had been conducted at Tunganamo Village, Pantai BaruSub-District, Rote Ndao District started from June until July in 2019, with the aim to understand: (1). Farmer group characteristic at Tunganamo Village, and (2). Farmer’s perception toward the roles of Onion Farmer Group at Tunganamo Village, Pantai Baru Sub-District, Rote Ndao District. Data were collected by using a survey method. Renspondents consisted of 43 farmers, were selected randomly from 76 farmer group members. Data measured by likert scale were analyzed by both quantitative and qualitative descriptive statistics.
Results of analysis indicated that: (1). The carateristics of onion farmer group located in Tunganamo Village, Pantai Baru Sub-District, Rote Ndao District as follows: there are three farmer groups existed in the research location namely Oliseu farmer group, which consisted of 24 farmers, Edene Ana farmer group which consisted of 27 farmers and Baru Terbit farmer group which consisted of 24 farmers. Those farmer groups were builded in the year of 2008, with the aim to get subsidy from government in relation to agriculture production facilities; and (2). Farmer’s perception on onion farmer group existed in Tunganamo Village, Pantai Baru Sub-District, the District of Rote Ndao was in “good category”, because the percentase of average score in reaching the maximum score was 68,46 % located in the range of 68-83 %.
STRATEGI PENGEMBANGAN AGROWISATA KOLAM PANCING P4S KARYA AGRI DI KELURAN BATUPLAT KECAMATAN ALAK KOTA KUPANG
Authors: Zola Muhammad Rizky , Pudjiastuti Sondang S. P. , Chamdra Santhy 
Published: September 2023

This study aims to determine 1.) the driving and inhibiting factors for the development of P4S Karya Agri fishing pound agrotourism, 2.) Karya Agri P4S fishing pond agrotourism development strategy.
The method used in this study is a descriptive analysis method. The respondents in this study are the owners of the P4S Karya Agri fish ponds, the fish pond workers, the fish pond visitors from a total of 85 people obtained with the Slovin approach formula, the head of the departement of tourism destinasions of the Kupang City Tourism Bureau, the Head of the Tourism Destinasions Departement of the Kupang City Tourism Bureau, the area cultivation of the Kupang City Fisheries Service. Data analysis tools used in this study 1.) IFAS and EFAS analysis 2.) SWOT analysis. This research is qualitative, the results show that 1.) the driving factors for the development from within (strengths), wich receive the highest category, are beautiful, cool and untouched natural panorama with an average of 3.76, inhibiting factors for the development from within (weaknesses) the highest category is given to the tourism development program, which is still simple 1.64, the driving factor for external development (opportunity) the highest category is a given to the area that offers the flexibility to develop tourism potential 3.68, the inhibiting factor for development of outside (threats) which received the highest category, was the 1.45 implementation of restrictions on community activities. 2.) Karya Agri P4S fishing pond agrotourism development strategy based on SWOT analysis is an SO strategy, as the cut – off point in quadrant (2.23 : 1.68) is in a growth position that has the strengths should make optimal use of it and it has possibilities.
RESPON PETANI TERHADAP USAHATANI KELOR DI DESA NOELBAKI KECAMATAN KUPANG TENGAH KABUPATEN KUPANG
Authors: Manafe Vikror , Pellokila Marthen Robinson , Herewila Kudji 
Published: September 2023

The study is purposed to figure out the factory that affecting the response of the farmer to undertake moringa farming, because it is one of farming field that just started to develop and it has economic value. The samples of this study were the farmer in Noelbaki villaege. According to purposive sampling method in oder to perform collecting data was carried out by questionnaires consequently tabulating analyzing with logistic regression model. Further, dependent variable (Y) is marked with number 1 as respons and number 0 as unrespons. The result of this study were showing factory that affecting farmer’s respon towards moringa farming are the Age (X1), the Experiece (X4), the Distance of home to farming location (X6), the Distance of farming location to market(X8).