bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining Regional Infrastructure Development Priorities in East Java Province
Authors: Sianturi R.S. , Kusuma S.H. , Farikha N. , Zubaidah A. F. , Zakina N. , Astuti S.C. , Amalia F. 
Published: June 2023

Abstract
Accelerating regional development through physical infrastructure development contributes to national economic growth. However, a prioritization of hard infrastructure investment is inevitable due to limited funding capacities among regions. This study aims to determine the priority of regional infrastructure development in East Java Province. First, this research identifies indicators to assess the infrastructure development priority using qualitative content analysis. Second, this research analyzes regional infrastructure development needs using Z-Score values. Finally, this study determines the infrastructure development priorities using the Klassen typology, infrastructure program availability, and dominant land use and base sectors to prioritize regional infrastructure development. The findings can be used as a reference in synchronizing policies and programs in East Java Province for the next five years.
Two-photon lifetime-based photoconversion of EGFP for 3D-photostimulation in FLIM
Authors: Strachotová Dita , Holoubek Aleš , Brodská Barbora , Heřman Petr 
Published: June 2023

Abstract
Enhanced green fluorescence protein (EGFP) is a fluorescent tag commonly used in cellular and biomedical applications. Surprisingly, some interesting photochemical properties of EGFP have remained unexplored. Here we report on two-photon-induced photoconversion of EGFP, which can be permanently converted by intense IR irradiation to a form with a short fluorescence lifetime and spectrally conserved emission. Photoconverted EGFP thus can be distinguished from the unconverted tag by the time-resolved detection. Nonlinear dependence of the two-photon photoconversion efficiency on the light intensity allows for an accurate 3D localization of the photoconverted volume within cellular structures, which is especially useful for kinetic FLIM applications. For illustration, we used the two photon photoconversion of EGFP for measurements of redistribution kinetics of nucleophosmin and histone H2B in nuclei of live cells. Measurements revealed high mobility of fluorescently tagged histone H2B in the nucleoplasm and their redistribution between spatially separated nucleoli.
Outpatient apheresis billing: A photopheresis model shows that hospital price transparency data remain difficult to interpret
Authors: Adkins Brian D , Booth Garrett S , Jacobs Jeremy W , Jones Heather , Mouslim Morgane C , Henderson Morgan A 
Published: June 2023

Abstract

Objectives
The US health care payment system is complex and difficult to interpret. Although federal regulations require that more data, in the form of charges and negotiated rates, be made available, compliance remains variable. We review chargemaster and negotiated rate values for extracorporeal photopheresis (ECP) to assess this variability. We sought to determine the availability of chargemaster and negotiated rates for health care consumers and to assess compliance and pricing among institutions using ECP as a model for apheresis billing.

Methods
We obtained ECP chargemaster data and negotiated rates from 20 institutions. We analyzed the availability of ECP chargemaster data and compared values with a previously published historic cohort. We evaluated the availability of negotiated rates and determined relative reimbursement using charge to reimbursement ratios. We determined calculated fines for hospitals based on bed size.

Results
Chargemaster availability increased from 2019 to 2022, though only 65% (13/20) of hospitals had both chargemaster and negotiated rate data. Chargemaster prices increased significantly from 2019 to 2022 (range, $3,586.83-$34,043.00). We reviewed 1,191 negotiated rates, with institutions averaging 93.6 different rates (SD, 189.5). Negotiated rates were variable, ranging from $3,586.83 to $34,043.00 per procedure. Reimbursement was higher among private insurers compared with reported Centers for Medicare & Medicaid Services negotiated rates. Of the 35% (7/20) that lacked chargemaster and negotiated rates, institutions faced an average annual fine of $1,430,800.

Conclusions
Despite recent financial penalties, ECP pricing data are often unavailable or inadequate. Current available resources are unlikely to benefit the average health care consumer who requires ECP.
Consensus label propagation with graph convolutional networks for single-cell RNA sequencing cell type annotation
Authors: Lewinsohn Daniel P , Vigh-Conrad Katinka A , Conrad Donald F , Scott Cory B 
Published: June 2023

Abstract

Motivation
Single-cell RNA sequencing (scRNA-seq) data, annotated by cell type, is useful in a variety of downstream biological applications, such as profiling gene expression at the single-cell level. However, manually assigning these annotations with known marker genes is both time-consuming and subjective.

Results
We present a Graph Convolutional Network (GCN)-based approach to automate the annotation process. Our process builds upon existing labeling approaches, using state-of-the-art tools to find cells with highly confident label assignments through consensus and spreading these confident labels with a semi-supervised GCN. Using simulated data and two scRNA-seq datasets from different tissues, we show that our method improves accuracy over a simple consensus algorithm and the average of the underlying tools. We also compare our method to a nonparametric neighbor majority approach, showing comparable results. We then demonstrate that our GCN method allows for feature interpretation, identifying important genes for cell type classification. We present our completed pipeline, written in PyTorch, as an end-to-end tool for automating and interpreting the classification of scRNA-seq data.

Availability and implementation
Our code for conducting the experiments in this paper and using our model is available at https://github.com/lewinsohndp/scSHARP.
Vitamin C Urinary Loss and Deficiency in Human Immunodeficiency Virus (HIV): Cross-sectional Study of Vitamin C Renal Leak in Women With HIV
Authors: Ebenuwa Ifechukwude , Violet Pierre-Christian , Michel Kate , Padayatty Sebastian J , Wang Yaohui , Tu Hongbin , Wilkins Kenneth J , Kassaye Seble , Levine Mark 
Published: June 2023

Abstract

Background
Reduced plasma vitamin C (vitC) concentrations in human immunodeficiency virus (HIV) may result from abnormal urinary excretion: a renal leak. VitC renal leak indicates underlying nutritional dysregulation independent of diet. We hypothesized that increased renal leak prevalence in HIV would be associated with deficient vitC concentrations.

Methods
We conducted an outpatient cross-sectional study of 96 women (40 HIV [PWH] and 56 without HIV [PWOH]) at the National Institutes of Health and Georgetown University. Renal leak was defined as abnormal urinary vitC excretion at fasting plasma concentrations &lt;43.2µM, 2 SDs below vitC renal threshold in healthy women. To determine the primary outcome of renal leak prevalence, matched urine and plasma samples were collected the morning after overnight fast. Secondary outcomes assessed group differences in mean plasma vitC concentrations and prevalence of vitC deficiency. Exploratory outcomes assessed clinical parameters associated with renal leak. VitC was measured by high-performance liquid chromatography with coulometric electrochemical detection.

Results
PWH had significantly higher renal leak prevalence (73%vs14%; OR (odds ratio):16; P&lt;.001), lower mean plasma vitC concentrations (14µMvs50µM; P&lt;.001), and higher prevalence of vitC deficiency (43%vs7%; OR:10; P&lt;.001) compared with PWOH, unchanged by adjustments for confounding factors. Significant predictors of renal leak included antiretroviral therapy (ART), Black race, older age, and metabolic comorbidities but not viral load or CD4 count. When compared with other chronic disease cohorts, PWH had the highest prevalence of renal leak and vitC deficiency (P&lt;.001).

Conclusions
High prevalence of vitC renal leak in HIV was associated with vitC deficiency, ART use, and race/ethnicity differences.
Acculturative Stress, Mental Health, and Well-Being among Deaf Adults
Authors: Aldalur Aileen , Pick Lawrence H 
Published: June 2023

Abstract
Acculturative stress is associated with negative mental health among culturally diverse individuals. Deaf and Hard-of-Hearing (DHH) individuals experience acculturative stress as they navigate within and between the Hearing and Deaf communities, yet, research has not examined the relationship between deaf acculturative stress and psychological functioning. This study examined the relationships between deaf acculturative stress, well-being, and symptoms of depression and anxiety. One hundred and ten DHH adults (71.6% female, 82.7% White, median age = 30–39) completed an online survey including the Multidimensional Inventory of Deaf Acculturative Stress (MIDAS), demographic questions, and measures of psychological functioning. After controlling for relevant sociodemographic factors, the MIDAS Stress from the Deaf and Hearing Community scales emerged as significant predictors of well-being and symptoms of anxiety and depression. Findings are discussed within the context of DHH sociocultural experiences, and suggestions for future research are offered to inform clinical work with DHH individuals.
Congenital membranous ostial stenosis of the left atrial appendage as a secondary finding in a patient with ST elevation myocardial infarction: a case report
Authors: Hanke David , Hamadanchi Ali , Schulze P Christian , Franz Marcus 
Published: June 2023

Abstract

Background
Stenoses of the left atrial appendage (LAA) represent a common complication after incomplete surgical ligation. However, the idiopathic entity is very rare. So far, there is uncertainty about the thromboembolic risk and potential benefit of anticoagulation in these patients. We report on congenital ostial stenosis of the LAA as a secondary finding in a patient with myocardial infarction.

Case summary
A 56-year-old patient presented with acute heart failure secondary to ST elevation myocardial infarction (STEMI) and eventually progressed to cardiogenic shock. A percutaneous coronary intervention and stent placement in the first diagonal branch and in the left anterior descending artery was performed in two sessions. There was a new onset of typical atrial flutter and paroxysmal atrial fibrillation with haemodynamically relevant tachycardia. Before synchronized electrical cardioversion, we performed transoesophageal echocardiography. Left atrial thrombi were ruled out. Surprisingly, we found membranous ostial stenosis of the LAA, resulting in a bidirectional flow pattern. After 28 days of treatment in the intensive care unit the patient had full clinical recovery.

Discussion
Given the very rare cases of congenital LAA ostial stenosis, there is uncertainty about the thrombogenicity and the potential benefit of anticoagulation or even a percutaneous closure of the LAA. We discuss possible similarities regarding the thromboembolic risk of patients with an idiopathic narrowing of the LAA to patients with incomplete surgical ligation and patients with a device leak after percutaneous LAA closure. Congenital ostial LAA stenosis represents a clinically relevant condition and may be considered as a potential hazard for thromboembolism.
Improved prognosis after cardiac resynchronization therapy over a decade
Authors: Leyva Francisco , Zegard Abbasin , Patel Peysh , Stegemann Berthold , Marshall Howard , Ludman Peter , de Bono Joseph , Boriani Giuseppe , Qiu Tian 
Published: June 2023

Abstract

Aims
The past decade has seen an increased delivery of cardiac resynchronization therapy (CRT) for patients with heart failure (HF). We explored whether clinical outcomes after CRT have changed from the perspective of an entire public healthcare system.

Methods and results
A national database covering the population of England (56.3 million in 2019) was used to explore clinical outcomes after CRT from 2010 to 2019. A total of 64 698 consecutive patients (age 71.4 ± 11.7 years; 74.8% male) underwent CRT-defibrillation [n = 32 313 (49.7%)] or CRT-pacing [n = 32 655 (50.3%)] implantation. From 2010–2011 to 2018–2019, there was a 76% increase in CRT implantations. During the same period, the proportion of patients with hypertension (59.6–73.4%), diabetes (26.5–30.8%), and chronic kidney disease (8.62–22.5%) increased, as did the Charlson comorbidity index (CCI ≥ 3 from 20.0% to 25.1%) (all P &lt; 0.001). Total mortality decreased at 30 days (1.43–1.09%) and 1 year (9.51–8.13%) after implantation (both P &lt; 0.001). At 2 years, total mortality [hazard ratio (HR): 0.72; 95% confidence interval (CI) 0.69–0.76] and total mortality or HF hospitalization (HR: 0.59; 95% CI 0.57–0.62) decreased from 2010–2011 to 2018–2019, after correction for age, race, sex, device type (CRT-defibrillation or pacing), comorbidities (hypertension, diabetes, chronic kidney disease, and myocardial infarction), or the CCI (HR: 0.81; 95% CI 0.77–0.85).

Conclusions
From the perspective of an entire public health system, survival has improved and HF hospitalizations have decreased after CRT implantation over the past decade. This prognostic improvement has occurred despite an increasing comorbidity burden.
Physics-guided deep-learning inversion method for the interpretation of noisy logging-while-drilling resistivity measurements
Authors: Noh Kyubo , Pardo David , Torres-Verdín Carlos 
Published: June 2023

SUMMARY
Deep learning (DL) inversion is a promising method for real-time interpretation of logging-while-drilling (LWD) resistivity measurements for well-navigation applications. In this context, measurement noise may significantly affect inversion results. Existing publications examining the effects of measurement noise on DL inversion results are scarce. We develop a method to generate training data sets and construct DL architectures that enhance the robustness of DL inversion methods in the presence of noisy LWD resistivity measurements. We use two synthetic resistivity models to test the three approaches that explicitly consider the presence of noise: (1) adding noise to the measurements in the training set, (2) augmenting the training set by replicating it and adding varying noise realizations and (3) adding a noise layer in the DL architecture. Numerical results confirm that each of the three approaches enhances the noise-robustness of the trained DL inversion modules, yielding better inversion results—in both the predicted earth model and measurements—compared to the basic DL inversion and also to traditional gradient-based inversion results. A combination of the second and third approaches delivers the best results.
Not Only Meaning… Verbel: The Electronic Dictionary of Paradigms of Polish Verbal Multiword Expressions
Authors: Przybyszewski Sebastian , Kosek Iwona , Czerepowicka Monika 
Published: June 2023

Abstract
This article presents Verbel: The Electronic Dictionary of Paradigms of Polish Verbal Multiword Expressions (MWEs) and discusses theoretical problems connected with compiling such a dictionary for inflectionally complex languages such as Polish. The dictionary includes over 5,000 Polish verbal MWEs and explicitly presents their forms and constraints in inflection. It also provides grammatical, semantic, pragmatic and prescriptive commentaries. The first part of the article covers the theoretical and methodological basis used in the compilation of the dictionary. Generally, a verbal MWE is inflected according to the paradigm of the verb which is its main component. However, MWEs may have some specific inflectional constraints connected with other factors (e.g. semantic, pragmatic), which result in different paradigms for verbal MWEs and for the verbs that are their main components. In the second part, the conception and content of the dictionary are discussed. Finally, the natural language processing tools that underlie the work on the dictionary are described.
Epidemiology and risk factors of 28-day mortality of hospital-acquired bloodstream infection in Turkish intensive care units: a prospective observational cohort study
Authors: Aslan Abdullah Tarık , Tabah Alexis , Köylü Bahadır , Kalem Ayşe Kaya , Aksoy Firdevs , Erol Çiğdem , Karaali Rıdvan , Tunay Burcu , Guzeldağ Seda , Batirel Ayşe , Dindar Emine Kübra , Akdoğan Özlem , Bilir Yeliz , Ersöz Gülden , Öztürk Barçın , Selçuk Mehtap , Yilmaz Mesut , Akyol Ahmet , Akbaş Türkay , Sungurtekin Hülya , Timuroğlu Arif , Gürbüz Yunus , Çolak Onur , Bayindir Yaşar , Eroğlu Ahmet , Ferlicolak Leyla , Çeşme Utku , Dağ Osman , Buetti Niccoló , Barbier François , Ruckly Stéphane , Staiquly Quentin , Timsit Jean-François , Akova Murat 
Published: June 2023

Synopsis

Objectives
To uncover clinical epidemiology, microbiological characteristics and outcome determinants of hospital-acquired bloodstream infections (HA-BSIs) in Turkish ICU patients.

Methods
The EUROBACT II was a prospective observational multicontinental cohort study. We performed a subanalysis of patients from 24 Turkish ICUs included in this study. Risk factors for mortality were identified using multivariable Cox frailty models.

Results
Of 547 patients, 58.7% were male with a median [IQR] age of 68 [55–78]. Most frequent sources of HA-BSIs were intravascular catheter [182, (33.3%)] and lower respiratory tract [175, (32.0%)]. Among isolated pathogens (n = 599), 67.1% were Gram-negative, 21.5% Gram-positive and 11.2% due to fungi. Carbapenem resistance was present in 90.4% of Acinetobacter spp., 53.1% of Klebsiella spp. and 48.8% of Pseudomonas spp. In monobacterial Gram-negative HA-BSIs (n = 329), SOFA score (aHR 1.20, 95% CI 1.14–1.27), carbapenem resistance (aHR 2.46, 95% CI 1.58–3.84), previous myocardial infarction (aHR 1.86, 95% CI 1.12–3.08), COVID-19 admission diagnosis (aHR 2.95, 95% CI 1.25–6.95) and not achieving source control (aHR 2.02, 95% CI 1.15–3.54) were associated with mortality. However, availability of clinical pharmacists (aHR 0.23, 95% CI 0.06–0.90) and source control (aHR 0.46, 95% CI 0.28–0.77) were associated with survival. In monobacterial Gram-positive HA-BSIs (n = 93), SOFA score (aHR 1.29, 95% CI 1.17–1.43) and age (aHR 1.05, 95% CI 1.03–1.08) were associated with mortality, whereas source control (aHR 0.41, 95% CI 0.20–0.87) was associated with survival.

Conclusions
Considering high antimicrobial resistance rate, importance of source control and availability of clinical pharmacists, a multifaceted management programme should be adopted in Turkish ICUs.
Regulating digital platforms: why, how, and why now
Authors: Cass-Gottlieb Gina 
Published: June 2023

Abstract
Like many competition agencies and governments around the world, the Australian Competition and Consumer Commission has formed the view that ex ante regulation is a necessary complement to address the competition (and consumer) harms posed by digital platforms. Our existing laws are not sufficient to address the anti-competitive conduct and corresponding harms we have observed in relation to digital platforms and the markets in which they operate. This paper explains our recommended model for regulatory reform and how it will address the competition harms that we have identified. Collaboration with international agencies has influenced our thinking in this space and continues to be important to ensure international coordination and alignment in regulatory reform. This paper concludes by looking ahead to the remainder of 2023 and beyond, as there is much work that remains to be done.
Insights into inactivation and response mechanisms of sublethal Listeria monocytogenes treated by cold plasma with joint transcriptomics and metabolomics
Authors: Pan Yuan-Yuan , Sun Da-Wen , Cheng Jun-Hu , Brust Henrike , Weltmann Klaus-Dieter 
Published: June 2023

Abstract

Aim
The aim of the current study is to elucidate the inactivation and molecular response pattern of sublethal Listeria monocytogenes to cold plasma-mediated two-pronged oxidative microenvironments from a high-throughput multi-omics perspective.

Methods and results
First joint transcriptomics and metabolomics analyses revealed that significantly expressed genes and metabolites were mainly involved in enhanced transmembrane transport and Fe2+/Cu+ efflux, amino acid limitation, cytoplasmic pH homeostasis, reconfiguration of central carbon metabolism flux, and energy conservation strategy, which triggered the surge of intracellular endogenous oxidative stress and finally mediated bacterial ferroptosis and pathogenicity attenuation. Typical antioxidant systems such as the TrxR-Trx system and common antioxidant genes (e.g. sodA, katA, ahpC, trxA, spxA) were inhibited, and the more prominent antioxidant pathways include methionine metabolism, the pentose phosphate pathway, and glutathione metabolism, as well as the DNA repair systems.

Conclusions
Therefore, our work confirmed from the transcriptional and metabolic as well as physiological levels that cold plasma-mediated intracellular oxidative stress induced big perturbations in pathways as a driving force for the inactivation and pathogenicity attenuation of L. monocytogenes.

Significance and impact of study
This study provided new insights for the construction of multi-dimensional mechanisms of bacterial inactivation and pathogenicity attenuation for the precise control and inactivation of microorganisms in plasma non-thermal processing.
“The credit of priority”: The Japanese Collection Loaned From the Netherlands to The Great Industrial Exhibition, Dublin, 1853
Authors: Baird Christina 
Published: June 2023

Abstract
The year 1853 marks a landmark in the history of Japanese art exhibitions within Britain and Ireland, being the year when the first clearly identified exhibition of Japanese items was displayed in an international exhibition in the British Isles. The Great Industrial Exhibition, Dublin, 1853, is of importance because the Japanese exhibition loaned from a Dutch collection illustrates the Dutch playing a significant role in the introduction of Japanese works of arts and industry into Britain and Ireland. This study explores the means by which the 1853 Japanese exhibition was assembled and questions why it was never given the “credit of priority” during the 1870s, at a time when discussions on this issue focused on the Japanese displays in the International Exhibition, London, 1862, and the Exposition Universelle, Paris 1867. In relation to these discussions, two texts from the 1870s, R. Alcock, Art and Art Industries in Japan1 and G. A. Audsley and J. L. Bowes, Keramic Art of Japan2 have been singled out for discussion.
Extracellular and intracellular functions of coiled-coil domain containing 3
Authors: Omari Sara , Lee Hyemin , Wang Jieqiong , Zeng Shelya X , Lu Hua 
Published: June 2023

Abstract
Coiled-coil domain containing 3 (CCDC3, also called Favine) is a highly conserved protein initially identified as a protein secreted from adipocytes and endothelial cells in the vascular system with endocrine-like functions. Recently, CCDC3 was also found to function as a nuclear tumor suppressor in breast cancers. Although it is still understudied, CCDC3, since its discovery, has been shown to play multiple roles in lipid metabolism, fatty liver, abdominal obesity, anti-inflammation, atherosclerosis, and cancer. This essay is thus composed to offer an overview of these extracellular endocrine-like and intracellular (nuclear) functions of CCDC3. We also discuss the possible underlying cellular and molecular mechanisms of CCDC3, the implications for clinical translation, and the remaining puzzles about this special molecule.