bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consortium for the Study of Pregnancy Treatments (Co-OPT): An international birth cohort to study the effects of antenatal corticosteroids
Authors: Frier Emily M. , Lin Chun , Reynolds Rebecca M. , Allegaert Karel , Been Jasper V. , Fraser Abigail , Gissler Mika , Einarsdóttir Kristjana , Florian Lani , Jacobsson Bo , Vogel Joshua P. , Zoega Helga , Bhattacharya Sohinee , Krispin Eyal , Henning Pedersen Lars , Roberts Devender , Kuhle Stefan , Fahey John , Mol Ben W. , Burgner David , Schuit Ewoud , Sheikh Aziz , Wood Rachael , Gyamfi-Bannerman Cynthia , Miller Jessica E. , Duhig Kate , Lahti-Pulkkinen Marius , Hadar Eran , Wright John , Murray Sarah R. , Stock Sarah J. 
Published: March 2023

Background
Antenatal corticosteroids (ACS) are widely prescribed to improve outcomes following preterm birth. Significant knowledge gaps surround their safety, long-term effects, optimal timing and dosage. Almost half of women given ACS give birth outside the “therapeutic window” and have not delivered over 7 days later. Overtreatment with ACS is a concern, as evidence accumulates of risks of unnecessary ACS exposure.

Methods
The Consortium for the Study of Pregnancy Treatments (Co-OPT) was established to address research questions surrounding safety of medications in pregnancy. We created an international birth cohort containing information on ACS exposure and pregnancy and neonatal outcomes by combining data from four national/provincial birth registers and one hospital database, and follow-up through linked population-level data from death registers and electronic health records.

Results and discussion
The Co-OPT ACS cohort contains 2.28 million pregnancies and babies, born in Finland, Iceland, Israel, Canada and Scotland, between 1990 and 2019. Births from 22 to 45 weeks’ gestation were included; 92.9% were at term (≥ 37 completed weeks). 3.6% of babies were exposed to ACS (67.0% and 77.9% of singleton and multiple births before 34 weeks, respectively). Rates of ACS exposure increased across the study period. Of all ACS-exposed babies, 26.8% were born at term. Longitudinal childhood data were available for 1.64 million live births. Follow-up includes diagnoses of a range of physical and mental disorders from the Finnish Hospital Register, diagnoses of mental, behavioural, and neurodevelopmental disorders from the Icelandic Patient Registers, and preschool reviews from the Scottish Child Health Surveillance Programme. The Co-OPT ACS cohort is the largest international birth cohort to date with data on ACS exposure and maternal, perinatal and childhood outcomes. Its large scale will enable assessment of important rare outcomes such as perinatal mortality, and comprehensive evaluation of the short- and long-term safety and efficacy of ACS.
Mucor and Malignancy: A Double-Hit Case of Intestinal Ischemia
Authors: Berger Benjamin T. , Townsend Matthew J. , Arbogast Mitchell K. , Van Kirk Jenny 
Published: March 2023

ABSTRACT
Mucormycosis is an invasive fungal infection due to molds in the order Mucorales. These opportunistic pathogens found in soil or decaying organic matter mostly affect immunocompromised hosts. Rhino-orbital-cerebral, pulmonary, gastrointestinal, cutaneous, and disseminated patterns are possible. We describe a case of angioinvasive colonic mucormycosis in a patient with recent diabetic ketoacidosis and undiagnosed colon adenocarcinoma. The diagnosis was made on histopathology after the patient developed intestinal ischemia and underwent hemicolectomy. This case highlights the potentially diverse manifestations of Mucorales infections, typical and atypical risk factors, and the index of suspicion necessary for early diagnosis and outcome optimization.
Optimized infrared-assisted extraction to obtain total lipid from microalgae Scenedesmus obliquus: a green approach
Authors: Correa-Aguado Hans Christian , Cerrillo-Rojas Gloria Viviana , Aguilera Flores Miguel Mauricio , Castillo Sergio Zavala , Morales-Domínguez José Francisco 
Published: March 2023

Abstract
Microalgae oil has great potential to address the growing energy demand and dependence on fossil fuels. However, the multilayered cell walls of microalgae hinder efficient extraction and enhanced lipid recovery. In this study, we develop a novel protocol based on near infrared-assisted extraction (NIRAE) technology to extract efficiently total lipids from Scenedesmus obliquus. Under a greener solvent extraction approach, the effect of nine non-polar/polar solvent systems in various ratios on lipid yield was tested, and the results were compared with Soxhlet, Folch, and Bligh–Dyer methods. The highest oil yields were NIRAE 15.43%, and Soxhlet 22.24%, using AcoEt/MeOH (1:2 v/v). For Folch and Bligh–Dyer, 9.11 and 10%, respectively. The optimized NIRAE conditions obtained using response surface methodology (RSM): 43.8 min, solvent/biomass 129.90:1 (m/v), and AcOEt/MeOH 0.57:2.43 (v/v) increased the oil yield significantly to 24.20%. In contrast to conventional methods, the overall optimized NIRAE process satisfied the requirements of a green extraction because of the simple and safe operation, less solvent toxicity, lower extraction time, and solvent and energy consumption.
Ethical issues in online interpreting training
Authors: Liu Hongyan , Lei Zhenhui 
Published: March 2023

Abstract
Although online education dissolves boundaries by providing “anywhere and anytime” teaching and learning opportunities, ethical concerns and challenges still exist. Interpreting training is preferably achieved in a face-to-face setting, as it concentrates on individual practice within an authentic interpreting environment for skill development rather than mere knowledge acquisition. This study examines ethical challenges and concerns in online interpreting training, including equality of learning outcomes, emotional support, privacy and audio/video data protection, and misconduct behaviours. Based on the observation of such ethical concerns, possible solutions for addressing such issues in the context of online interpreting training are explored. We suggest developing professional interpreting learning platforms and software, adopting virtual reality technology, compiling a multimodal corpus, and establishing a virtual community to achieve better learning outcomes.
Power in Global Governance: Power without Rulers?
Authors: Cruz Ortiz de Landázuri Manuel 
Published: March 2023

Abstract
Is there global governance beyond the State? What kind of power emerges in a global arena? In contrast to the neorealist position, which stresses the role of states in the constitution of international power, many Foucauldian interpretations have emerged that emphasize the role of power networks that are constituted through an episteme. In this article I will focus on global governance through a Platonic notion of power and the relationship Plato establishes between the power of norms and rules. I argue that global governance should be understood as a network of power with different intermediations, based on a global constitution taken as a cognitive frame behind the international legal order. In this sense, new forms of power appear, and are different from the traditional state power activity, based on settled practices and norms. My main thesis is that there can be power without a clear ruler, but there is no power without rational order (based on norms, dispositions, and communicative intermediations), therefore, I examine which kind of rational order appears in global governance in accordance to Plato’s account of power and some remarks recently made by Byung-Chul Han.
XRD and cytotoxicity assay of submitted nanomaterial industrial samples in the Philippines
Authors: Legaspi Enrico Daniel R. , Sitchon Ma. Stefany Daennielle G. , Jacinto Sonia D. , Basilia Blessie A. , Martinez Imee Su 
Published: March 2023

Abstract
Distinct properties that nanomaterials possess compared to their bulk counterparts are attributed to their characteristic high surface area to volume ratios, and the prevalence of structure and shape effects at the nanoscale. However, these interesting properties are also accompanied by health hazards that are not seen in bulk materials. In the context of Philippine research and industry, the issue of nanosafety and the creation of nanotechnology guidelines have long been overlooked. This is of particular importance considering that nanotechnology research in the Philippines leans heavily towards medicinal and agricultural applications. In this study, nanomaterial samples from the industry submitted through the Philippine Industrial Technology Development Institute (ITDI) were analyzed using XRD and MTT cytotoxicity assay. XRD results show significant band broadening in the diffraction patterns of halloysite nanoclay, bentonite nanoparticles, silver nanoparticles, and CaCO3 nanoparticles, indicating that samples were in the nanometer range. The diffraction pattern of TiO2, however, did not exhibit band broadening, which may be due to the tendency of TiO2 nanoparticles to aggregate. Submitted samples were also assessed for their effect on cell viability using MTT cytotoxicity assay. Among these samples, only silver nanoparticles exhibited cytotoxicity to the AA8 cell line.
Surveys of Plastics in Post-1950 Non-published Book Collections
Authors: Chu Cancy , Barrett Melanie , Bunn Sarah , Zilio Francesca , Bell Julianne , Nel Petronella 
Published: March 2023

Abstract
Research over the past three decades has demonstrated that certain plastics in cultural materials are inherently unstable, displaying short lifespans and accelerating the degradation of neighbouring collection materials. Knowledge of the conservation of plastics is increasingly common in museum settings. However, less information is available on conserving plastics found in paper-based collections, and even less guidance on the materials and deterioration of plastic components found in book and document bindings. As plastics have been present in popular bookbinding materials since the mid-twentieth century, collection care professions require knowledge and methods for preserving these materials entering book collections. The aim of this paper is to determine strategies for the care of post-1950s books containing plastic. Collection surveys were conducted to determine the materials, structures, and degradation patterns of non-published books found in archive and archive-like settings at the South Australian Museum, the Art Gallery of New South Wales, and the Grimwade Centre for Cultural Materials Conservation at the University of Melbourne. A methodology combining condition reporting and infrared spectroscopy identified six plastic polymers in 35 binding styles that are summarised as 10 binding types. Recommendations are made for the use of preventive storage strategies responding to four categories of damage.
Estimation and testing of the factor-augmented panel regression models with missing data
Authors: Xiao Difa , Wang Lu , Wu Jianhong 
Published: March 2023

Abstract
This paper focuses on the factor-augmented panel regression models with missing data and individual-varying factors. A so-called CCEM estimator for the slope coefficient is proposed and its asymptotic properties are investigated under some regularity conditions. Furthermore, a joint test statistic is constructed for serial correlation and heteroscedasticity in the idiosyncratic errors. Under the null hypothesis, the test statistic can be shown to be asymptotically chi-square distributed. Monte Carlo simulation results show that the proposed estimator and test statistic have desired performance in finite samples.
Outcome and prognostic factors for pituitary carcinomas: lessons from a systematic review
Authors: Raymond Perrine , Raverot Gérald , Ilie Mirela-Diana 
Published: March 2023

Purpose
The purpose of this work was toinvestigate the clinicopathological characteristics at the initial diagnosis of the pituitary tumor and at pituitary carcinoma (PC) diagnosis, alongside with the management and outcomes of PCs, and identify potential prognostic factors and therapeutic strategies associated with the clinical outcome.

Methods
PubMed was searched in May 2021 for articles in English and French reporting PCs, the diagnosis of which was made on the presence of metastases. The cases without histological proof and with either another cancer present or an atypical history for a pituitary tumor were excluded.

Results
One hundred and eighty-one articles reporting 207 cases were included, which included 38% corticotroph and 29% lactotroph carcinomas. An initial Ki67 index ≥10% was associated with shorter survival after the initial diagnosis (P = 0.01). Cases with early metastases were associated with both higher initial Ki67 index (P = 0.01) and shorter survival after PC diagnosis (P = 0.001). Interestingly, cases with short survival after PC diagnosis were associated with shorter time between the initial diagnosis and PC diagnosis (P = 0.0006) and had both higher initial Ki67 index (P = 0.003) and higher Ki67 index of the metastasis (P = 0.03). In addition, cases with long survival after PC diagnosis had received more frequently both systemic treatment after PC diagnosis (P = 0.0005) and local treatment for metastases (P < 0.0001).

Conclusions
An initial Ki67 index ≥10% is associated with worse outcome and appears as a promising early marker of future metastasis. Its presence should lead to an intensified surveillance and to a more timely management. Clinicians should not hesitate to use local treatment, independent of whether systemic treatment is used.
Fremdheitsinszenierungen der deutschsprachigen Emigrationsrepräsentationen. Wege der Integration im Roman Tauben fliegen auf
Authors: Vincze Ferenc 
Published: March 2023

AbstractIn the German-language literature of the last twenty to thirty years, there has been a tendency to depict strangeness and integration. Through Melinda Nadj Abonji’s novel, this paper attempts to point out the phenomena that problematize integration and strangeness, which would be related to the space represented or which can be read from representations through space.
POLÍTICA NACIONAL DE PAGAMENTO POR SERVIÇO AMBIENTAL
Authors: Santos Silas Silva , Gelfin Airton Roberto , Bertão Samira Monayari 
Published: March 2023

O artigo tem por objetivo discutir as consequências jurídico-sociais ocasionadas pela promulgação da Lei nº 14.119/2021, denominada “Lei do Pagamento por Serviços Ambientais”, cujo artigo 9º, parágrafo único, prevê a possibilidade de contemplar, com o pagamento de serviços ambientais (PSA), os proprietários e possuidores de Áreas de Preservação Permanente (APPs), de Reserva Legal (ARLs) e de Áreas afetadas por Limitações Administrativas de caráter ambiental. As APPs e as ARLs, expressamente previstas no Código Florestal Brasileiro (Lei nº 12.651/2012) são espécies de limitações administrativas, destinadas a instrumentalizar os preceitos fundamentais do artigo 225 da Constituição Federal referente ao meio ambiente ecologicamente equilibrado. As limitações administrativas em geral são caracterizadas como obrigações de caráter geral, destinadas a assegurar um interesse público, impostas pelo Estado independentemente de indenizações ou compensações. Assim, o presente artigo contemplou uma análise dialética do artigo 9º, parágrafo único, da Lei nº 14.119/21, frente o Código Florestal e a Constituição Federal, no que se refere à tutela do meio ambiente. O resultado dessa análise evidenciou que a Lei 14.119/21, ao prever o PSA às APPs, ARLs e Áreas de Limitações Administrativas de caráter ambiental, desconsiderou que pela natureza jurídica, a preservar e recuperar o meio ambiental nessas áreas é uma obrigação inerente ao direito de propriedade, independente de indenização ou compensação. A solução encontrada parte de uma interpretação sistemática da Lei 14.119/21, da Lei 12.651/12 e da Constituição Federal de 1988, prevalecendo a certeza sobre a obrigação dos proprietários, possuidores e detentores em preservar e recuperar o meio ambiente junto as APPs, ARLs e Áreas de Limitações Administrativas de caráter ambiental independentemente da contemplação pelo PSA.
Palavras-chave: Pagamento por Serviços Ambientais. Área de Reserva Legal. Área de Preservação Permanente. Limitações Administrativas. Retrocesso Ambiental.
Digital Humanities Projects in Educational Process
Authors: Atamanchuk Viktoriia , Atamanchuk Petro 
Published: March 2023

The purpose of the study is to outline the main directions and prospects of digital humanities development; to find out the main principles of the scientific space transformation, caused by the implementation of digital humanities; to define the transdisciplinary ontology as digital humanities important tool.
Methodology of the article is based on implementation of principle of information systematicity and its further modeling in educational and scientific aspects. The information is being analysed for distinguishing its structural components and their semantic and functional coherence. According to the structural and semantic analysis of information, the modeling of information representation is performed. As the productive way of modeling is the transdisciplinary ontology, so principle of transdisciplinarity is one of the basical principle in the study.
Transdisciplinary ontology seems to be an important tool of digital humanities. Using ontology it is possible to perform educational information in structured form with all its components, organized in hierarchical construction, and their correlation depiction. Transdisciplinary ontology provides various forms of information graphical display, perception of which helps to understand essential causal factors, principles of information arrangement, its regularities
Recommendation for further transdisciplinary ontology application is based on the possible ontology extention by new elements adding according to the enrichment of educational material being learned.
The Role of Surgical Debridement in the Treatment of Systemic Tetanus
Authors: Samson Trinity K. , Bono Kenneth T. 
Published: March 2023

Case:
Tetanus is a potentially life-threatening infection of Clostridium tetani characterized by painful muscular spasms and hypertonia. Surgical debridement of infected tissue is intended to reduce the number of spores and limit the extent of the disease. We report a case of an unvaccinated 13-year-old adolescent boy who presented with systemic tetanus after stepping on a nail, and we describe the role that surgical debridement of infected tissue plays in optimizing outcomes.

Conclusion:
Orthopaedic surgeons must remain aware of the role of surgical debridement of wounds potentially infected with C. tetani because it is an important component of proper management.
Impact of Internal Malrotation of the Femur Followed by Derotational Osteotomy as Demonstrated by 3D Gait Analysis
Authors: Olson Brooke J. , Lenhart Rachel , Schmeling Gregory J. , Fritz Jessica M. 
Published: March 2023

Case:
An 18-year-old man with 48° of internal malrotation of the femur after nailing underwent derotational osteotomy with gait dynamics and electromyography data collected preoperatively and postoperatively. Hip abduction and internal foot progression angles were significantly deviated from normal preoperatively compared with the contralateral side. At 10 months postoperatively, the hip was abducted and externally rotated throughout the entire gait cycle. His Trendelenburg gait had resolved, and he reported no residual functional concerns. Before corrective osteotomy, walking velocity was significantly slower with shorter stride lengths.

Conclusion:
Significant internal malrotation of the femur impairs hip abduction and foot progression angles as well as gluteus medius activation during ambulation. Derotational osteotomy considerably corrected these values.
A Squeaking Knee Is a Rare Complication of ACL Surgery
Authors: Frazer Philip M. , Talbot William 
Published: March 2023

Case:
We report a rare case of a 36-year-old woman who underwent anterior cruciate ligament surgery (ACL), which was complicated by a squeaking knee postoperatively. The squeaking noise was likely due to migrating nonabsorbable suture engaging with the articular surface and created significant psychological stress but had no impact on the functional outcome of the patient. We eliminated the noise with an arthroscopic debridement of the suture that had migrated from the tibial tunnel.

Conclusion:
A squeaking knee after ACL surgery due to migrating suture is a rare complication that, in this case, improved with surgical debridement and diagnostic imaging seems to have a limited role.
An Off-Label Use of a Tensioned Proximal Humerus Plate for Tibiotalar Fusion
Authors: Aneja Arun , Sneed Chandler R. , Pectol Richard W. , Kavolus Matthew W. , Foster Jeffrey A. , Kinchelow Daria L. 
Published: March 2023

Case:
A 70-year-old man presented with a left pilon fracture after a 10-foot fall from a ladder. The severe amount of comminution, joint destruction, and impaction from this injury eventually resulted in a tibiotalar fusion. Owing to multiple tibiotalar fusion plates not being long enough to span the extent of the fracture, a tensioned proximal humerus plate was used as an alternative.

Conclusion:
We do not endorse the off-label use of a tensioned proximal humerus plate for all tibiotalar fusions; however, we do believe that this is a useful technique in certain situations with large zones of distal tibial comminution.
Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of lipophagy
Authors: Cui Donghai , Wang Zixiang , Dang Qianli , Wang Jing , Qin Junchao , Song Jianping , Zhai Xiangyu , Zhao Ling , Lu Gang , Liu Hongbin , Liu Runping , Shao Changshun , Zhang Xiyu , Liu Zhaojian 
Published: March 2023

Abstract
Regulation of alternative splicing (AS) enables a single transcript to yield multiple isoforms that increase transcriptome and proteome diversity. Here, we report that spliceosome component Usp39 plays a critical role in the regulation of hepatocyte lipid homeostasis. We demonstrate that Usp39 expression is downregulated in hepatic tissues of NAFLD and non-alcoholic steatohepatitis (NASH) subjects. Hepatocyte-specific Usp39 deletion leads to increased lipid accumulation, spontaneous steatosis and impaired autophagy. Combined analysis of RIP-seq and RNA-seq data reveals that Usp39 regulates AS of several autophagy-related genes. For example, deletion of Usp39 results in alternative 5’ splice site selection of exon 6 in Heat shock transcription factor 1 (Hsf1) and consequently reduced expression. Importantly, overexpression of Hsf1 restores attenuated lipid accumulation caused by Usp39 deficiency. Taken together, our findings indicate that Usp39-mediated AS is crucial for sustaining lipophagy and lipid homeostasis in the liver.