bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytotoxic Activity of Essential Oil from Leaves of Myrcia splendens against A549 Lung Cancer Cells
Authors: Montalvão Monalisa Martins , Batista Franciel Felix , Santos Edmilson William Propheta dos , Santos Jileno Ferreira , Júnior Waldecy Lucca , Farias Atenilton Santos , Ribeiro Adauto Souza , Cavaleiro Carlos , Machado Samísia Maria Fernandes , Scher Ricardo , Corrêa Cristiane Bani 
Published: March 2023

Abstract
Background: Plants of the Myrcia genus have been widely used in folk medicine to treat various diseases. The Myrcia splendens species has a diverse chemical constitution, but the biological activities of its essential oil have not been well investigated.
Objective: To carry out the chemistry characterization and evaluate the in vitroantitumor effect of the essential oil from the leaves of the species Myrcia splendens (MSEO) in different tumor lines.
Methods: The essential oil obtained from M. splendens (MSEO) leaves was analyzed by GC/MS. The cytotoxic activity of the MSEO was evaluated in vitro using the MTT assay. Clonogenic and wound healing assays were used to analyze colony formation and migratory capacity of lung adenocarcinoma cells, respectively. Morphological changes were observed by fluorescence using Phalloidin/FITC and DAPI stains.
Results: Chemical analysis identified 22 compounds, corresponding to 88% of the sample. Major compounds were the sesquiterpenic hydrocarbons bicyclogermacrene (15.4%), germacrene D (8.9%) and E-caryophyllene (10.1%). MSEO was highly cytotoxic in A549, B16-F10 and THP-1 cancer cells. A549 human lung adenocarcinoma cell line was chosen to continue the experiments, due to the high incidence and mortality rates of this type of cancer. MSEO reduced colony formation of at all concentrations and inhibited the migratory capacity of A549 cells at concentrations of 20 and 40 ug/mL. Furthemore, the MSEO induced apoptotic in A549 cells at all concentrations tested.
Conclusion: MSEO may be a promising natural agent in anti-cancer applications.
Fog Computing Network Security Based on Resources Management
Authors: BenDaoud Wided , Othmen Salwa , Hamdi Monia , Khdhir Radhia , Hmam Habib 
Published: March 2023

Abstract
Fog Computing paradigm is designed as an extension of cloud computing due to the need for a supporting platform that is capable to provide the requirements of the Internet of Things (IoT). However, due to its features, fog obviously confronts numerous security and privacy risks, such as huge scale geolocation, heterogeneity, and mobility. Indeed, there are many problems resulting from security violations and breaches. Thus, to exceed these problems, we propose an efficient access control system, ameliorated with appropriate monitoring function and risk estimation. Moreover, a comprehensive resource management mechanism is proposed to ameliorate the system performance and so to maintain low latency. Our aim is to further enhance data security, privacy and resource management for IoT-users. To demonstrate the efficiency, feasibility, and security of our proposed scheme, we perform an extensive simulation using Network Security Simulator (Nessi2).
Patient Satisfaction study in Outpatient Setting in Tertiary Academic Hospital
Authors: Abaalkhayl Mohammed , Abukraym Nader , Al-Najjar Hani 
Published: March 2023

Abstract
Purpose: To analyze and assess of satisfaction to the quality and performance of services provided in the outpatients Clinics of Tertiary Academic Care Hospital, and explore what is the factors affecting on it.
Methods: In a cross-sectional study at university hospitals in the Qassim region of Saudi Arabia, 476 outpatient online surveys were completed. The main content of the study was the basic characteristics of the patients. Statistical description, to identify influencing factors, chi-square analysis was utilized.
Results: The survey found that total outpatient satisfaction was 76.69±25.17, and the higher satisfaction factor scores were hospital facilities, Attitude and corporation of pharmacy staffs, language and communication of the physician, and registration process. The factors with lower scores were ease of finding OPD clinic, ease to find outpatients location, availability of prescribed medication.
Conclusion: For the continuation of the outpatient service process, patients with various educational levels, marital status, and first-time hospital visitors may receive special attention when receiving outpatient care.
Title: Presence of fatty liver disease leads to unusual rise of liver enzymes in patients with common bile duct colic.
Authors: Siriwardana Rohan Chaminda , Ediriweera Deleepa Senajith , Paranaheva Lakmali , Ekanayake Chanaka Sandharuwan , Thilakarathne Suchintha 
Published: March 2023

Abstract

BackgroundAcute common bile duct (CBD) obstruction due to calculi leads to intra ductal hypertension and transient hepato-cellular injury. Fatty liver disease (FLD) has adverse impact on hepatic microcirculation. This study compares liver enzymes, inflammatory markers and bilirubin levels in patients with and without fatty liver disease (FLD) presenting with common bile duct (CBD) obstruction.MethodsCBD colic was diagnosed based on clinical, radiological and biochemical criterion. Patients were divided in to two groups as presence or absence of FLD based on ultra sound scan and the macroscopic appearance of liver during surgery. AST, ALT, bilirubin level and inflammatory markers were prospectively assessed and the peak levels were compared between the two groups.ResultsOut of 42 individuals, there were 22 (52.3%) patients with FLD. Median body mass index was 26.9 (24.1 – 30.8) in fatty liver group compared to 25.7 (23.5 – 26.2) in others. Individuals with FLD showed high AST (558.5 vs. 247.0, p = 0.005), ALT (467 vs. 228.5, p = 0.005) and bilirubin (3.8 vs. 2.2, p = 0.015) levels compared to those without FLD. According to multiple linear regression models, high AST and ALT levels showed significant associations with FLD after adjusting for age, gender, BMI, amylase and CRP levels. The median enzyme level at two weeks did not show a difference.ConclusionsPresence of FLD causes unusual rise of AST and ALT levels in patients with CBD stones. This rise is transient.
Prediction and early warning of daily number of childhood common respiratory diseases based on weighted combination model and CUSUM
Authors: Chen Cong , Qin Jiajie , Deng Yutong , Li Ying , Yang Juan , Jia Wei , Wang Xuying , Guan Jing , Liu Wei 
Published: March 2023

Abstract
Background: Childhood common respiratory diseases are the most common diseases that could cause great harm to children’s health. Constructing a weighted combination and early warning models of the daily number of childhood common respiratory diseases is of great significance in analyzing the trend of the daily number of childhood common respiratory diseases in the future, and providing data support for hospital personnel regulation and resource planning.
Methods: Due to the comprehensive characteristics of the trend, periodicity, autocorrelation and weekday effect of the daily number of childhood common respiratory diseases, a seasonal autoregressive integrated moving average (SARIMA) model was selected to capture the trend, periodicity and autocorrelation and a Holt-Winters model was constructed to consider the weekday effect. In addition, a multivariate long short-term memory (LSTM) model, combined with the lag effects of temperature and pollutant concentration on the daily number of childhood common respiratory diseases, was established.Based on the residual correction, a weighted combination model with the prediction results of the three models was constructed; meanwhile, a cumulative sum (CUSUM) early warning model was built. The mean absolute percentage error (MAPE) was used to evaluate the performance of the models.
Results: The models were applied to forecast and warn the short-termly daily number of childhood common respiratory diseases based on the recent 2 years of daily visit data of a large-scale comprehensive hospital for children in Tianjin.The MAPE of the weighted combination model was 3.01%, which was the smallest overall. At the same time, the early warning situation of the predictive values and the real values were consistent. Both of them indicated that the weighted combination model had good forecasting performance.
Conclusions: The weighted combination and early warning models can accurately predict the daily number of childhood common respiratory diseases, and send out the corresponding early warning signals, which will provide a scientific basis for the prevention and control of childhood common respiratory diseases.
Application of real-time data processing system of Internet of Things based on blockchain technology in the financial field of Yangtze River Delta urban agglomeration
Authors: Fei Xuanshu 
Published: March 2023

Abstract
After more than 40 years of long-term development, as a pioneer of China's reform and opening up, the Yangtze River Delta region has made tremendous economic progress and strong scientific and technological innovation strength, which has made the economy flourish and scientific and technological innovation strength strong. However, in the process of financial growth in the Yangtze River Delta, there are also financial structures that do not match the optimization of industrial structure, thus hindering the quality and efficiency of industrial structure optimization, thus affecting the strategic function of industrial development. For the development of the financial field, this paper applies the real-time data processing system of the Internet of Things based on blockchain technology to analyze the financial industry of the Yangtze River Delta urban agglomeration. The Internet of Things, based on the technology of real-time data processing system, can store different types of financial assets. These assets are a common component of supporting the application of the Internet of Things. They mix and build a powerful back-end process that can support the data processing application of the Internet of Things. Therefore, the Internet of Things data network and other information are stored in the data structure, so that data analysis and consolidation can be carried out with consensus, Thus, the processing efficiency of relevant financing data in the Yangtze River Delta region has been greatly improved, and the development process of the financial sector in the region has been effectively accelerated. Therefore, the research on this issue will enable the financial industry to give full play to its potential as a major component of national economic development, so as to maximize the improvement of the industrial structure and promote the development of blockchain and Internet of Things technologies.
High Prevalence of Acute Brain Injury on Brain Magnetic Resonance Imaging in Acute Respiratory Distress Syndrome
Authors: Huang Merry , Gedansky Aron , Hassett Catherine E. , Shoskes Aaron , Duggal Abhijit , Uchino Ken , Cho Sung-Min , Buletko Andrew Blake 
Published: March 2023

Abstract
Objective: Acute Respiratory Distress Syndrome(ARDS) is an acute inflammatory respiratory failure condition that may be associated with acute brain injury (ABI). We aimed to describe the prevalence and types of ABI detected by brain MRI among ARDS patients.
Methods: We retrospectively reviewed and collected data on ABI as detected by brain MRI during index hospitalization of all ARDS patients at a single tertiary center in the United States from January 2010 to October 2018. ABIs were classified as cerebral ischemia (ischemic infarct and hypoxic ischemic brain injury) or cerebral hemorrhage (intraparenchymal hemorrhage, cerebral microbleeds, subarachnoid hemorrhage, and subdural hematoma). Descriptive statistics were conducted.
Results: Of the 678 ARDS patients, 66 (9.7%) underwent brain MRI during their ARDS illness. The most common indication for brain MRI was encephalopathy (45.4%) and the median time from hospital admission to MRI was 10 days (interquartile range 4-17). Of 66, 29 (44%) had MRI evidence of ABI including cerebral ischemia in 33% (22/66) and cerebral hemorrhage in 21% (14/66). Among those with cerebral ischemia, common findings were bilateral globus pallidus infarcts (n=7, 32%), multifocal infarcts (n=5, 23%), and diffuse hypoxic ischemic brain injury (n=3, 14%). Of those with cerebral hemorrhage, common findings were cerebral microbleeds (n=12, 86%) and intraparenchymal hemorrhage (n=2, 14%). ARDS patients with cerebral hemorrhage had significantly greater use of rescue therapies including prone positioning (28.6% vs 5.8%, p = 0.03), inhaled vasodilator (35.7% vs 11.5%, p = 0.046), and recruitment maneuver (14.3% vs 0%, p = 0.04).
Conclusion: Among selected patients with ARDS who underwent brain MRI, almost a half had ABI most commonly including bilateral globus pallidus infarcts and cerebral microbleeds.
Evaluation of urinary system ultrasonography, uroflowmetry and voiding diary results in children with daytime urinary incontinence
Authors: Yener Sevim , İlçe Zekeriya 
Published: March 2023

Abstract
Purpose
To assess examine the results of urinary system ultrasonography, uroflowmetry and voiding diary for children patients presenting withday time urinary incontinence.
Patients and methods
Patients aged 5-17 years with day time urinary incontinence were retrospectively analyzed. Urinary system ultrasonography, uroflowmetry, complete urinalysis and two-day voiding diary were recorded for all patients. Comorbid diseases and surgeries were determined with a detailed history.
Results
A total of 1805 patients were identified. Abnormal USG findings were detected in 385 (21.3%) patients. The highest bladder capacity detected in the voiding diary was found to be below the expected bladder capacity in 41.2% of the patients, while the bladder capacity measured in the uroflowmeter was low in 65.4% of the patients. Urinary tract infection was detected in 315 patients in the complete urinalysis. Associated disease was seen in 401 patients with a detailed history.
Conclusion
We think that ultrasonographic evaluation in these patients should include the entire urinary system, since upper urinary system anomalies can be seen not only in the bladder but also in the upper urinary tract.
We think that a well-prepared voiding diary provides sufficient data in terms of bladder volume instead of bladder volume measured by bladder ultrasonography and/or uroflowmetry.
Amazon forests a net carbon source during drought and under high rates of human-disturbance
Authors: Rosan Thais , Sitch Stephen , O'Sullivan Michael , Basso Luana , Wilson Chris , Silva Camila V. J. , Gloor Manuel , Fawcett Dominic , Heinrich Viola , de Souza Jefferson Goncalves , Bezerra Francisco , von Randow Celso , Mercado Lina , Gatti Luciana , Wiltshire Andy , Friedlingstein Pierre , Pongratz Julia , Schwingshackl Clemens , Williams Mathew , Smallman Luke , Knauer Jürgen , Arora Vivek , Kennedy Daniel , Tian Hanqin , Wenping Yuan , Jain Atul , Falk Stefanie , Poulder Ben , Arneth Almut , Sun Qing , Zaehle Sönke , Walker Anthony , Kato Etsushi , Yue Xu , Bastos Ana , Ciais Philippe , Wigneron Jean-Pierre , Albergel Clement , Aragão Luiz 
Published: March 2023

Abstract
The Amazon is the largest continuous tropical forest in the world and plays a key role in the global carbon cycle. Human-induced disturbances and climate change have impacted the Amazon carbon balance. Here we conduct a comprehensive analysis of state-of-the-art estimates of the contemporary land carbon fluxes in the Amazon. Over the whole Amazon region bottom-up methodologies suggest a small average carbon sink over 2010-2020, in contrast with a carbon small source simulated by top-down inversions (2010-2018). However, these estimates are not significantly different from one another when accounting for their large individual uncertainties, highlighting remaining knowledge gaps, and urgent need to reduce such uncertainties. Nevertheless, both methodologies agreed on an Amazon net carbon source during recent climate extremes and that south-eastern Amazon was a net land carbon source over the whole study period (2010-2020). Overall, our results point to increasing human-induced disturbances (deforestation and forest degradation by wildfires) and reduction in the old-growth forest sink during drought. If the current trends in deforestation and forest degradation and regional drying continue, it will have negative implications for reducing carbon emissions and maintaining globally important natural carbon stocks, as part of the requirements for achieving the Paris Agreement goals.
Rituximab treatment of adults with primary focal segmental glomerulosclerosis
Authors: wang liuwei , yu lu , wang yulin , guo yanhong , zhai zihan , tang lin 
Published: March 2023

Abstract
Objective: To evaluate the efficacy and safety of rituximab (RTX) in the treatment of primary focal segmental glomerulosclerosis (FSGS) in adults.
Method: The clinical data of patients with primary FSGS who received RTX treatment in the First Affiliated Hospital of Zhengzhou University were analyzed retrospectively. The selected patients received RTX twice or four times, with a single dose of 375mg/m2, and the interval between two times of administration of RTX was 2-4 weeks. The treatment target is to achieve the clearance of B cells (peripheral blood B cell count<5/ μ l). The primary outcome measures were remission and recurrence of renal disease, and the secondary outcome measures were adverse events (AEs) and renal outcomes.
Result: A total of 14 FSGS patients were included, including 12 males, 9 with glucocorticoid-dependent or frequently relapsing nephrotic syndrome, and 3 with newly diagnosed nephrotic syndrome. After RTX treatment, 7 patients with glucocorticoid-dependent/recurrent nephrotic syndrome were completely relieved. At 6 months of follow-up, glucocorticoids were discontinued in all patients except 1 patient. The other 5 patients achieved partial remission (PR), of which 1 patient relapsed after PR, and 1 initial patient achieved complete remission (CR). One patient progressed to end-stage renal disease (ESRD) after 4 months of follow-up.
Conclusion: RTX in the treatment of adult glucocorticoid-dependent/relapsing FSGS can reduce the risk of recurrence and help to decline or discontinue the use of glucocorticoid and immunosuppressants. Keywords: Rituximab, FSGS, treatment effect, SDNS, FRNS
Glycemic control assessed by continuous glucose monitoring during pregnancy in women with type 1 diabetes and its association with preeclampsia and gestational hypertension, an observational Swedish cohort study
Authors: Ögge Linda Englund , Dotevall Annika , Elfvin Anders , Sandgren Ulrika , Wallstersson Bernadette , Bohlin Linnea , Sjödell Mårten , Augustinsson Jaine , Hagman Anna 
Published: March 2023

Abstract
Introduction: Women with type 1 diabetes type have increased risk of preeclampsia but it is not fully understood if degree of glycemic control is associated with this risk. Aims of this study was to assess associations between glycemic control using CGM (continuous glucose monitoring) and risk of preeclampsia and gestational hypertension.
Material and methods: 120 pregnant Swedish women with type 1 diabetes using CGM were included. Background factors and pregnancy outcomes were collected from medical records. CGM data were collected via the internet based Diasend. Mean glucose, standard deviation (SD), percentage of time within (TIT), below (TBT), and above (TAT) target was presented in each trimester in women with and without preeclampsia. Associations between CGM and preeclampsia and gestational hypertension were analyzed with logistic regression and adjusted for confounders.
Results: 20 women (16.6%) developed preeclampsia. There were no significant differences in maternal characteristics between women with or without preeclampsia except for smoking. Glycemic control improved with each trimester but was not optimal in either group. When analyzing associations between glucose variables and preeclampsia, no significant associations were found after adjustment for confounders. In nulliparous women there was a trend, however not significant, of higher mean glucose, higher SD, less TIT, more TAT and less TBT, in those who developed preeclampsia. We found no significant associations between glycemic control and development of gestational hypertension.
Conclusions: Degree of glycemic control assessed by CGM was not associated with development of preeclampsia or gestational hypertension in women with type 1 diabetes in this study.
Food insecurity and social inequalities in households headed by older people in Brazil: a secondary cross-sectional analysis of a national survey.
Authors: Ribeiro Eloah Costa de Sant Anna , Cherol Camilla Christine de Souza , Salles-Costa Rosana , Junior Paulo Cesar Pereira de Castro , Ferreira Aline Alves 
Published: March 2023

Abstract
Background: The older population in Brazil is associated with the presence of food security. However, there is evidence that some food insecurity persistence in households headed by older people, especially at the most severe levels, and has a possible relationship with social inequality. The objective of this study was to analyze the prevalence and factors associated with moderate/severe food insecurity in households headed by older people.
Methods: A cross-sectional study based on a national representation of older adults aged ≥ 60 years was conducted using data from the 2017/2018 Family Budget Survey. In the study, moderate/severe food insecurity was the dependent variable, with food insecurity measured using the Brazilian Food Insecurity Scale. Prevalence and odds ratio estimates were generated with 99% confidence intervals. Data analysis was performed using STATA software.
Findings: A total of 16,314 households headed by older people were identified. Approximately 10.2% of these households were in the moderate/severe range for food insecurity, with most headed by older people, primarily female (11.9%), self-declared indigenous people (25.5%), lack of schooling (18.3%) and with a per capita income of up to 1/2 minimum wage (29.6%). The analysis model found that color/race, region, schooling, per capita household income, and social benefits received in the household were statistically significant factors (p value <0.01).
Conclusion:Moderate/severe food insecurity in households headed by older people is associated with the marked social inequalities present in Brazil. Intensifying the need for a different view of this age group.
Anatomical morphology of maxillary first premolars in a Chinese population assessed using Cone-beam Computed Tomography
Authors: chen feng , Huang Xinzhao , Liu Qi , Liu Xinyue , Shen Zhe , Li Ru , Zhou Bingxin , Ding Cheng , Zhong Liangjun 
Published: March 2023

Abstract
The aim of this research was to study the anatomical shape of the maxillary first premolars in Chinese people using cone-beam computed tomography (CBCT). The anatomical morphology of root canals and crowns of 637 first premolars from China was observed by CBCT. In this study, 73.3% of the 637 maxillary first premolars were single roots, 26.7% were double roots, and 41.8%(n = 266) of the 637 maxillary first premolars were type IV in the light of Vertucci. The most frequent distance between two root canal orifices was 2-3mm (n = 257, 47.6%). There was a range in distance from the top of the medullary chamber to the central fossa (from 4.25mm to 4.45mm), with a mean distance of 4.35 ± 0.62mm. The incidence of mesial depression was 65.6%, and the mean angle of the mesial depression was 151.8 ± 10.5 degrees. In conclusion, the root canal system and anatomical morphology of the maxillary first premolar in the Chinese population exhibit a wide range of morphologies based on CBCT.