bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility study of deep learning‐based markerless real‐time lung tumor tracking with orthogonal X‐ray projection images
Authors: Zhou Dejun , Nakamura Mitsuhiro , Mukumoto Nobutaka , Matsuo Yukinori , Mizowaki Takashi 
Published: December 2022

AbstractPurposeThe feasibility of a deep learning‐based markerless real‐time tumor tracking (RTTT) method was retrospectively studied with orthogonal kV X‐ray images and clinical tracking records acquired during lung cancer treatment.MethodsTen patients with lung cancer treated with marker‐implanted RTTT were included. The prescription dose was 50 Gy in four fractions, using seven‐ to nine‐port non‐coplanar static beams. This corresponds to 14–18 X‐ray tube angles for an orthogonal X‐ray imaging system rotating with the gantry. All patients underwent 10 respiratory phases four‐dimensional computed tomography. After a data augmentation approach, for each X‐ray tube angle of a patient, 2250 digitally reconstructed radiograph (DRR) images with gross tumor volume (GTV) contour labeled were obtained. These images were adopted to train the patient and X‐ray tube angle‐specific GTV contour prediction model. During the testing, the model trained with DRR images predicted GTV contour on X‐ray projection images acquired during treatment. The predicted three‐dimensional (3D) positions of the GTV were calculated based on the centroids of the contours in the orthogonal images. The 3D positions of GTV determined by the marker‐implanted RTTT during the treatment were considered as the ground truth. The 3D deviations between the prediction and the ground truth were calculated to evaluate the performance of the model.ResultsThe median GTV volume and motion range were 7.42 (range, 1.18–25.74) cm3 and 22 (range, 11–28) mm, respectively. In total, 8993 3D position comparisons were included. The mean calculation time was 85 ms per image. The overall median value of the 3D deviation was 2.27 (interquartile range: 1.66–2.95) mm. The probability of the 3D deviation smaller than 5 mm was 93.6%.ConclusionsThe evaluation results and calculation efficiency show the proposed deep learning‐based markerless RTTT method may be feasible for patients with lung cancer.
Event‐triggered asynchronous filtering for networked fuzzy non‐homogeneous Markov jump systems with dynamic quantization
Authors: Zhu Jin , Xie Zhi , Zhao Yun‐Bo , Dullerud Geir E. 
Published: December 2022

SummaryThe asynchronous filtering problem for networked fuzzy non‐homogeneous Markov jump systems is investigated, with the consideration of packet dropout and quantization. An event‐triggered dynamic quantization scheme is proposed, and a stability criterion is given to ensure the stochastic stability of the filtering error systems with desired extended dissipative performance. This performance provides a unified framework in the sense that it can degenerate to , , dissipativity and passivity filter, respectively, under certain parameter sets. Furthermore, an asynchronous filter design method with extended dissipative performance is given based on the proposed stability criterion. In this method, the existence of the quantizer is ensured by dynamic quantization levels and the solution scope of the filter is enlarged by a free‐connection weighting matrices method. The theoretical design and analysis is finally evaluated using a practical example.
Recent Progress of Flexible Photodetectors Based on Low‐Dimensional II–VI Semiconductors and Their Application in Wearable Electronics
Authors: Peng Mingfa , Wen Zhen , Sun Xuhui 
Published: December 2022

AbstractFlexible photodetectors exhibit many advantages such as a good bendability, foldability, and even stretchability as well as weight light, which have triggered a widely concerned in wearable electronics including wearable monitoring, wearable image sensing, self‐powered integrated electronics, etc. Recently, various II–VI semiconductor nanostructures have become promising candidates in flexible photodetectors due to their unique characteristics, such as direct bandgap semiconductors, excellent optical and electric properties, high quantum efficiency, and inherent mechanical flexibility. Herein, the most recent progress on low‐dimensional (0D, 1D, 2D, and related heterostructures) II–VI semiconductors based flexible photodetectors and their application in wearable electronic is reviewed. First, a brief introduction of the main sensing mechanisms and key figures of merits for photodetectors is presented. Then, the recent progresses on flexible photodetectors are provided, in which the functional materials synthesis methods are also discussed. More importantly, the applications of the flexible photodetectors are summarized, including wearable monitoring sensors, image sensors, and self‐powered integrated wearable electronics. Finally, the challenges and the future research direction of the flexible photodetectors are discussed, meanwhile the outlook for the development of flexible photodetectors in the future integration of wearable electronic is also provided.
A Review on the Status and Challenges of Cathodes in Room‐Temperature Na‐S Batteries
Authors: Lei Yao‐Jie , Liu Han‐Wen , Yang Zhuo , Zhao Ling‐Fei , Lai Wei‐Hong , Chen Mingzhe , Liu Huakun , Dou Shixue , Wang Yun‐Xiao 
Published: December 2022

AbstractThe cathode materials for sodium‐sulfur batteries have attracted great attention since cathode is one of the important components of the sodium‐sulfur battery, and there are cathode materials that have high capacity, non‐toxicity, and cost‐efficiency. Nevertheless, due to their low Coulombic efficiency and proneness to cycling decay, the practical application of the sodium–sulfur battery has always been suppressed. In terms of the responsibility of these problems, the polysulfide shuttle and the sluggish kinetics are the main culprits. To address these issues, impeding the notorious reaction between polysulfide intermediates on the cathode and improve the kinetics reaction on the anode are extremely important. Herein, a comprehensive review is prepared of different approaches to increasing the electrochemical performance and strengthening the stability of cathodes. The influences of various choices and the consequent properties of the cathode in relation to the whole sodium–sulfur battery performance is investigated. Finally, the current research challenges related to cathodes for sodium–sulfur batteries and future perspectives are also discussed.
Orally Administrable Aggregation‐Induced Emission‐Based Bionic Probe for Imaging and Ameliorating Dextran Sulfate Sodium‐Induced Inflammatory Bowel Diseases
Authors: Wang Wenyuan , Wu Ya , Wang Yihui , Wang Rui , Deng Cheng , Yi Luyang , Wang Lufang , He Mengrong , Zhou Wuqi , Xie Yuji , Jin Qiaofeng , Chen Yihan , Gao Tang , Zhang Li , Xie Mingxing 
Published: December 2022

AbstractAs macrophage infiltration is significantly related to the progression of inflammatory bowel disease (IBD), monitoring the macrophages is a valuable strategy for IBD diagnosis. However, owing to the harsh physiological environment of the gastrointestinal tract and enzymatic degradation, the development of orally administrable imaging probes for tracking macrophages remains a considerable challenge. Accordingly, herein, an orally administrable aggregation‐induced emission biomimetic probe (HBTTPIP/β‐glucan particles [GPs]) is developed for tracing macrophages; HBTTPIP/GPs can diagnose and alleviate dextran sulfate sodium (DSS)‐induced colonic inflammation and self‐report the treatment efficiency. The fluorophore HBTTPIP can effectively aggregate in GPs, restricting intramolecular rotation and activating the fluorescence of HBTTPIP. After being orally administrated, HBTTPIP/GPs are phagocytosed by intestinal macrophages, which then migrate to colonic lesions, enabling non‐invasive monitoring of the severity of IBD via in vivo fluorescence imaging. Notably, oral HBTTPIP/GPs ameliorate DSS‐induced IBD by inhibiting the expressions of pro‐inflammatory factors and improving colonic mucosal barrier function. Furthermore, these HBTTPIP/GPs realize self‐feedback of the therapeutic effects of GPs on DSS‐induced colitis. The oral biomimetic probe HBTTPIP/GPs reported herein provide a novel theranostic platform for IBD, integrating non‐invasive diagnosis of IBD in situ and the corresponding treatment.
Low‐Coordination Trimetallic PtFeCo Nanosaws for Practical Fuel Cells
Authors: Bu Lingzheng , Liang Jiashun , Ning Fandi , Huang Ju , Huang Bolong , Sun Mingzi , Zhan Changhong , Ma Yanhang , Zhou Xiaochun , Li Qing , Huang Xiaoqing 
Published: December 2022

AbstractDeveloping high‐performance catalysts for fuel cell catalysis is the most critical and challenging step for the commercialization of fuel cell technology. Here 1D trimetallic platinum–iron–cobalt nanosaws (Pt3FeCo NSs) with low‐coordination features are designed as efficient bifunctional electrocatalysts for practical fuel cell catalysis. The oxygen reduction reaction (ORR) activity of Pt3FeCo NSs (10.62 mA cm−2 and 4.66 A mg−1Pt at 0.90 V) is more than 25‐folds higher than that of the commercial Pt/C, even after 30 000 voltage cycles. Density functional theory calculations reveal that the strong inter‐d‐orbital electron transfer minimizes the ORR barrier with higher selectivity at robust valence states. The volcano correlation between the intrinsic structure featured with low‐coordination Pt‐sites and corresponding electronic activities is discovered, which guarantees high ORR activities. The Pt3FeCo NSs located in the membrane electrode assembly (MEA) also achieve very high peak power density (1800.6 mW cm−2) and competitive specific/mass activities (1.79 mA cm−2 and 0.79 A mg−1Pt at 0.90 ViR‐free cell voltage) as well as a long‐term lifetime in specific H2O2 medium for proton‐exchange‐membrane fuel cells, ranking top electrocatalysts reported to date for MEA. This work represents a class of multimetallic Pt‐based nanocatalysts for practical fuel cells and beyond.
Carbon‐Hybridized Hydroxides for Energy Conversion and Storage: Interface Chemistry and Manufacturing
Authors: Xie Yuanyang , Yu Chang , Ni Lin , Yu Jinhe , Zhang Yafang , Qiu Jieshan 
Published: December 2022

AbstractCarbon‐hybridized hydroxides (CHHs) have been intensively investigated for uses in the energy conversion/storage fields. Nevertheless, the intrinsic structure–activity relationships between carbon and hydroxides within CHHs are still blurry, which hinders the fine modulation of CHHs in terms of practical applications to some degree. This review aims to figure out the intrinsic role of carbon materials in CHHs with a focus on the interface chemistry and the engineering strategy in‐between two components. The fundamental effects of the carbon materials in enhancing the charge/mass transfer kinetics are first analyzed, particularly the extra electron pathways for fast charge transfer and the anchoring sites for boosting the mass transfer. Subsequently, the surface‐guided/confined effects of carbon materials in CHHs to modify the morphology and tailor the hydroxides, and functional heterojunction for regulating the inner electronic structure are decoupled. The methods to efficiently construct a stable yet robust solid–solid heterointerface are summarized, including oxygen functional groups engrafting, topological defective sites construction and heteroatom incorporation to activate the inert carbon surface. The smart CHHs in some typical energy applications are demonstrated. Additionally, the methodologies that can reveal the hybridization electron configuration between two components are summed up. At last, the perspective and challenges faced by the CHHs for energy‐related applications are outlined.
Honeycomb‐Layered Oxides With Silver Atom Bilayers and Emergence of Non‐Abelian SU(2) Interactions
Authors: Masese Titus , Kanyolo Godwill Mbiti , Miyazaki Yoshinobu , Ito Miyu , Taguchi Noboru , Rizell Josef , Tachibana Shintaro , Tada Kohei , Huang Zhen‐Dong , Alshehabi Abbas , Ubukata Hiroki , Kubota Keigo , Yoshii Kazuki , Senoh Hiroshi , Tassel Cédric , Orikasa Yuki , Kageyama Hiroshi , Saito Tomohiro 
Published: December 2022

AbstractHoneycomb‐layered oxides with monovalent or divalent, monolayered cationic lattices generally exhibit myriad crystalline features encompassing rich electrochemistry, geometries, and disorders, which particularly places them as attractive material candidates for next‐generation energy storage applications. Herein, global honeycomb‐layered oxide compositions, Ag2M2TeO6 (.) exhibiting atom bilayers with sub‐valent states within Ag‐rich crystalline domains of Ag6M2TeO6 and ‐deficient domains of (). The ‐rich material characterized by aberration‐corrected transmission electron microscopy reveals local atomic structural disorders characterized by aperiodic stacking and incoherency in the bilayer arrangement of atoms. Meanwhile, the global material not only displays high ionic conductivity but also manifests oxygen‐hole electrochemistry during silver‐ion extraction. Within the ‐rich domains, the bilayered structure, argentophilic interactions therein and the expected sub‐valent states (, etc.) are theoretically understood via spontaneous symmetry breaking of SU(2)× U(1) gauge symmetry interactions amongst 3 degenerate mass‐less chiral fermion states, justified by electron occupancy of silver and 5s orbitals on a bifurcated honeycomb lattice. This implies that bilayered frameworks have research applications that go beyond the confines of energy storage.
Srinivaspura Aging, Neuro Senescence and COGnition (SANSCOG) study: Study protocol
Authors: Ravindranath Vijayalakshmi ,   SANSCOG Study Team
Published: December 2022

AbstractIntroductionProspective, population‐based, aging, and cognition studies are an important approach to understand normal and pathological aging processes.MethodsThis is a longitudinal, community‐based cohort study (n = 10,000) in rural India, with long‐term follow‐up for comprehensive evaluation of risk and protective factors associated with cognitive changes during aging. All participants will undergo comprehensive clinical, neurocognitive, and biochemical assessments. Genotyping using genome‐wide association studies will be done for all participants. Whole genome sequencing and brain imaging (magnetic resonance imaging) will be done in a subset.ResultsThis study will generate a rich database of clinical, neurocognitive, biochemical, neuroimaging, and genetic data that can help identify risk and protective factors for dementia and other related disorders.DiscussionThis longitudinal study is first of its kind, involving comprehensive evaluations, spanning phenotype to genotype, in a rural Indian cohort, and has major public health implications.
Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ‐PET, neurodegeneration, and cognition
Authors: Chatterjee Pratishtha , Vermunt Lisa , Gordon Brian A. , Pedrini Steve , Boonkamp Lynn , Armstrong Nicola J. , Xiong Chengjie , Singh Abhay K. , Li Yan , Sohrabi Hamid R. , Taddei Kevin , Molloy Mark , Benzinger Tammie L. S. , Morris John C. , Karch Celeste , Berman Sarah , Chhatwal Jasmeer , Cruchaga Carlos , Graff‐Radford Neill R. , Day Gregory S , Farlow Martin , Fox Nick , Goate Alison , Hassenstab Jason , Lee Jae‐Hong , Levin Johannes , McDade Eric , Mori Hiroshi , Perrin Richard , Sanchez‐Valle Raquel , Schofield Peter R. , Levey Allan , Jucker Mathias , Masters Colin L. , Fagan Anne M. , Bateman Randall J. , Martins Ralph N. , Teunissen Charlotte ,   and the Dominantly Inherited Alzheimer Network
Published: December 2022

AbstractBackgroundGlial fibrillary acidic protein (GFAP) is a promising candidate blood‐based biomarker for Alzheimer's disease (AD) diagnosis and prognostication. The timing of its disease‐associated changes, its clinical correlates, and biofluid‐type dependency will influence its clinical utility.MethodsWe evaluated plasma, serum, and cerebrospinal fluid (CSF) GFAP in families with autosomal dominant AD (ADAD), leveraging the predictable age at symptom onset to determine changes by stage of disease.ResultsPlasma GFAP elevations appear a decade before expected symptom onset, after amyloid beta (Aβ) accumulation and prior to neurodegeneration and cognitive decline. Plasma GFAP distinguished Aβ‐positive from Aβ‐negative ADAD participants and showed a stronger relationship with Aβ load in asymptomatic than symptomatic ADAD. Higher plasma GFAP was associated with the degree and rate of neurodegeneration and cognitive impairment. Serum GFAP showed similar relationships, but these were less pronounced for CSF GFAP.ConclusionOur findings support a role for plasma GFAP as a clinical biomarker of Aβ‐related astrocyte reactivity that is associated with cognitive decline and neurodegeneration.Highlights
Plasma glial fibrillary acidic protein (GFAP) elevations appear a decade before expected symptom onset in autosomal dominant Alzheimer's disease (ADAD).
Plasma GFAP was associated to amyloid positivity in asymptomatic ADAD.
Plasma GFAP increased with clinical severity and predicted disease progression.
Plasma and serum GFAP carried similar information in ADAD, while cerebrospinal fluid GFAP did not.
TRIM25 mutation (p.C168*), coding for an E3 ubiquitin ligase, is a cause of early‐onset autosomal dominant dementia with amyloid load and parkinsonism
Authors: Gómez‐Tortosa Estrella , Baradaran‐Heravi Yalda , Dillen Lubina , Choudhury Nila Roy , Agüero Rabes Pablo , Pérez‐Pérez Julián , Kocoglu Cemile , Sainz M. José , Ruiz González Alicia , Téllez Raquel , Cremades‐Jimeno Lucía , Cárdaba Blanca ,   EU EOD Consortium, Van Broeckhoven Christine , Michlewski Gracjan , van der Zee Julie 
Published: December 2022

AbstractINTRODUCTIONPatients with familial early‐onset dementia (EOD) pose a unique opportunity for gene identification studies.METHODSWe present the phenotype and whole‐exome sequencing (WES) study of an autosomal dominant EOD family. Candidate genes were examined in a set of dementia cases and controls (n = 3712). Western blotting was conducted of the wild‐type and mutant protein of the final candidate.RESULTSAge at disease onset was 60 years (range 56 to 63). The phenotype comprised mixed amnestic and behavioral features, and parkinsonism. Cerebrospinal fluid and plasma biomarkers, and a positron emission tomography amyloid study suggested Alzheimer's disease. WES and the segregation pattern pointed to a nonsense mutation in the TRIM25 gene (p.C168*), coding for an E3 ubiquitin ligase, which was absent in the cohorts studied. Protein studies supported a loss‐of‐function mechanism.DISCUSSIONThis study supports a new physiopathological mechanism for brain amyloidosis. Furthermore, it extends the role of E3 ubiquitin ligases dysfunction in the development of neurodegenerative diseases.Highlights
A TRIM25 nonsense mutation (p.C168*) is associated with autosomal dominant early‐onset dementia and parkinsonism with biomarkers suggestive of Alzheimer's disease.
TRIM25 protein studies support that the mutation exerts its effect through loss of function.
TRIM25, an E3 ubiquitin ligase, is known for its role in the innate immune response but this is the first report of association with neurodegeneration.
The role of TRIM25 dysfunction in development of amyloidosis and neurodegeneration merits a new line of research.
Fabrication of PAN/PA6//rGO‐TiO2 electrospun nanofibers membrane with self‐cleaning performance under visible‐light
Authors: Ebrahimi Fatemeh , Nabavi Seyed Reza , Omrani Abdollah 
Published: December 2022

AbstractRegenerative photocatalytic membranes have gained considerable attention for both their unique properties and practical applications in energy and environmental areas. Reduced graphene oxide‐ titanium dioxide (rGO‐TiO2) electrosprayed onto an electrospun PAN/PA6 for photocatalytic and antifouling experiments. The prepared nanohybrid and membrane a were characterized using FESEM, TEM, AFM, EDX, XRD and DRS techniques. Simultaneous electrospinning of PAN and PA6 increased the mechanical strength of nanofibers by 85%. The rGO‐TiO2 caused increased hydrophilicity, wettability, and ultrahigh water flux up to 1885 Lm−2 h−1 in the fabricated membrane. The membrane has good rejection ratio for methylene blue and the photodegradation of MB can occur in the presence of visible light (λ = 440–830 nm) and can recover its permeability. The fabricated structure, has the lowest total and irreversible membrane fouling ratio, giving the membrane higher antifouling and self‐cleaning properties.
Tortoises and turtles from Huayquerías del Este (late Miocene–early Pliocene), Mendoza, Argentina
Authors: de la Fuente Marcelo S. , Romano Muñoz Cristo O. , González Ruiz Pablo , Garrido Alberto C. , Forasiepi Analía M. , Jannello Juan M. , Maniel Ignacio J. 
Published: December 2022

AbstractWe report new occurrences of Testudinidae and Chelidae from 11 different fossil sites in the Huayquerías and Tunuyán formations (late Miocene–Pliocene) in the Huayquerías del Este, Mendoza, Argentina. A total of 36 specimens were collected, representing at least three taxa from two different clades: 80.6% Testudinidae and 19.4% Chelidae. Testudinids are present throughout the stratigraphic succession, in alluvial, fluvial, and interdune sedimentary environments, represented by dorsal and plastron carapace plates, with some remains of the appendicular skeleton. A complete articulated plastron with some peripheral plates of the carapace was also recognized and is assigned to the extant speciesChelonoidis chilensis, representing the oldest record for this taxon (late Miocene, Messinian). Another possible morphotype was recognized in the form of a large scapular girdle and femur that likely corresponded to an individual with a dorsal carapace of about 80 cm. This assemblage of small and large tortoise species is recognized for first time in the Messinian Age/Stage of Mendoza. Chelids are mostly restricted to fluvial deposits in the upper part of the Huayquerías Formation, except for two specimens which appear in the lower part. One specimen is represented by a right half plastron of an indeterminate Chelidae species which could correspond to a carapace of up to 24 cm in length with plastral lobes narrower than those observed inPhrynopsspecies. Another specimen is characterized by a large costovertebral tunnel in the carapace, peripheral plates of the posterior margin of the carapace with ornamentation of fine grooves forming irregular polygons.