bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of Interactive Multimedia-based Learning: an Effective Strategy of Teaching Art History
Authors: Boakye Akwasi Adomako , Essel Harry Barton , Appiah Ernest , Essuman Michael Ato 
Published: July 2023

Abstract
Background: Interactive multimedia, a dynamic technology, requires users’ input to deliver information through words, graphics, images, or videos. Educational research on Interactive Multimedia is scattered throughout the literature. This dispersion is a problem for teachers and students who intend to use technology as a means to teach and learn; hence, to assist them, this research is being undertaken to put the information on Interactive Multimedia together. The research focuses on the following:
a) The effects of the instructions given under the Interactive Multimedia on the learning outcomes of students and
b) The concerns, trends, and gaps that will guide future Interactive Multimedia research and development.
Main Body: The review identified fifteen (15) journal articles from five (5) publishers published between January 2011 and December 2021 using the four-step Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach. Science Direct, Taylor and Francis, Emerald, Academia and PLOS ONE, were used to carry out the search. Observations into the educational application of Interactive Multimedia were made through tabular analysis.
Conclusion: This review shows that when Interactive Multimedia is used in all disciplines of education, whether formal or informal, it enhances student performance, satisfaction, and participation. Interactive Multimedia is increasingly used as a platform to teach complex things and harness students' understanding. Therefore, more qualitative research on the use of Interactive Multimedia is necessary, especially when studying educators' viewpoints. Further research is needed to apply educational theories into course design using Interactive Multimedia.
Weekly minutes of moderate to vigorous physical activity is associated with movement quality in overweight and obese older adults
Authors: Rekant Julie , Chambers April , Suri Anisha , Hergenroeder Andrea , Sejdic Ervin , Brach Jen 
Published: July 2023

Abstract

Background Physical activity can improve function and decrease healthcare spending among overweight and obese older adults. Although unstructured physical activity has been related to cardiometabolic improvements, the relationship between unstructured activity and movement quality is unclear. Aims This study aimed to evaluate the association of amount of unstructured free-living moderate-vigorous physical activity (MVPA) with measures of movement quality in overweight and obese older adults. Methods The association of MVPA with movement quality was assessed in 165 overweight and obese older adults (Age: 77.0(8.0) years; Body mass index (BMI): 29.2(5.3) kg/m2). Participants performed overground walking, the Figure of 8 Walk test, and the Five-Times Sit to Stand. Weekly physical activity was measured using a waist-worn Actigraph activity monitor. Results Movement quality during straight path (gait speed (ρ = 0.30,p < 0.01), stride length (ρ = 0.33,p < 0.01), double-limb support time (ρ=-0.26,p < 0.01), and gait symmetry (ρ = 0.17,p = 0.02)) and curved path (F8W time (ρ=-0.22,p < 0.01) and steps (ρ=-0.22,p < 0.01)) walking were associated with weekly minutes of MVPA after controlling for age. Five-Times Sit to Stand performance was not significantly associated with weekly minutes of MVPA (ρ=-0.10,p = 0.13). Conclusions Older adults with high BMIs who are less active also demonstrate poorer movement quality which should be targeted in interventions to promote healthy aging, decrease falls, and delay disability development. Future work should explore if these associations are observed in middle-aged adults so targeted interventions can be implemented even earlier in the disability development continuum.
Experimental hydraulic parameters of drainage grate inlets with a horizontal outflow in the broad-crested weir mode
Authors: Zhuk Volodymyr , Matlai Ivan , Zavoiko Bohdan , Popadiuk Ihor , Pavlyshyn Vitaliy , Mysak Ihor , Mysak Pavlo 
Published: July 2023

Abstract

The accurate assessment of discharge coefficients for different types of water inlets is crucial for minimizing modelling errors in drainage systems thus reducing the risk of flooding in adjacent areas. This study experimentally investigated the hydraulic characteristics of gully grate inlets with water seal and horizontal outflow, with nominal outlet pipe diameters of 100 and 150 mm, using a laboratory setup that meets the requirements of a special European regulation. Transition depths from the weir to the orifice mode were determined, and it was found that the perforated grates significantly increased the hydraulic resistance compared to the bar grates, resulting in a corresponding decrease in the discharge capacity of gully inlets. Power–law relationships between the weir discharge coefficient and gauge head were obtained for both bar and perforated grate inlets, as well as between the discharge coefficient and Froude number at the perimeter of grate inlets. These findings provide important insights for optimizing the design and performance of water inlets, particularly in the weir mode, which is critical for the proper functioning of drainage systems.
The Potential Role of Immunotherapy in Wilms’ Tumor: Opportunities and
Challenges
Authors: Sanatkar Seyed Amir , Heidari Arash , Arya Shahrzad , Ghasemi Mina , Rezaei Nima 
Published: July 2023

Abstract:
Wilms' tumor (WT) is the most common renal malignancy in children, accounting for more than
90% of all pediatric renal cancers. Although this tumor is generally responsive to treatment, relapses and deaths
still occur in a significant proportion of patients. The genetic alterations commonly found in WT and also its
unique histological features and the tumor microenvironment suggest that the immune system may play a crucial
role in the disease's development and progression. The limitations of conventional therapies, including
surgery, chemotherapy, and radiotherapy, in preventing recurrence in WT patients and their potential for exerting
long-term side effects, necessitate the application of novel therapeutic strategies, like immunotherapy, in
this disease. Immunotherapy is an emerging cancer treatment approach based on the concept of harnessing the
patient's immune system to fight tumor cells. This approach has demonstrated promising results in various
types of cancers due to its relatively high specificity, efficacy, and tolerability. However, the precise effects of
immunotherapy in WT remain to be explored. For this purpose, this review highlights the potential implication
of different immunotherapy approaches, like monoclonal antibodies, adoptive cell therapy, and immune checkpoint
inhibitors, in patients with WT, with a particular emphasis on the tumor's genetic and histological features.
Although much remains to be learned about the optimal use of immunotherapy for this disease, the available
evidence suggests that immunotherapy has the potential to significantly improve outcomes for patients
with WT. However, there is still a substantial need for conducting further studies, especially randomized controlled
trials, to determine the most effective immunotherapy strategy for this tumor. Moreover, the potential
beneficiary roles of the combination of immunotherapy and conventional treatments should be investigated in
future research.
The Utilization and Development of Viral Vectors in Vaccines as a Prophylactic
Treatment Against Ebola Virus as an Emerging and Zoonotic Infectious
Disease
Authors: Garcia Anthony , Grundmann Oliver 
Published: July 2023

Abstract:
Alongside the prescription of commonly used antivirals, such as acyclovir, remdesivir,
oseltamivir, and ciprofloxacin, the most efficient way to prevent or treat communicable diseases is by
vaccination. Vaccines have been the most efficient way to prevent or treat highly transmissible infectious
agents, such as Ebola, Anthrax, and Dengue Fever. Most epidemics of these highly transmissible
infectious agents occur in places, such as South America, Central America, Tropical Asia, and Africa,
where the availability of resources and access to adequate healthcare are limited. However, recent
events in history have proven that even with access to resources and proper healthcare, those in firstworld
countries are not invincible when it comes to infectious diseases and epidemics. The Ebola virus
outbreak in West Africa highlighted the gaps in therapeutic advancement and readiness and led to
the rapid development of novel vaccine approaches. Viral vectors, in the case of the Ebola vaccine the
Vesicular Stomatitis Virus (VSV), can be safely used to activate or initiate the innate adaptive immune
response to protect against viral infection. When developed properly and with extensive study,
novel vaccine approaches allow physicians and health experts to control the rate at which viruses
spread or prevent transmission. This review will discuss the advantages of viral vector vaccines, their
chemistry and development, and the pathophysiology of the Ebola virus to develop advantageous and
efficacious treatments.
Major Targets Involved in Clinical Management of Migraine
Authors: Rushendran Rapuru , Chitra Vellapandian , Ilango Kaliappan 
Published: July 2023

Background:
There has been a protracted effort to identify reliable targets for migraine.
It is believed that each year, hundreds of millions of individuals worldwide suffer from migraines,
making this widespread neurological ailment the second leading cause of years of disability
worldwide. The rationale of this study is to identify the major targets involved in migraine attacks.

Methods:
For this review, specialized databases were searched, such as PubMed, EMBASE, DynaMed
Plus, and Science Direct databases that included the pathophysiological mechanisms of
migraine, focusing on in vitro and in vivo studies in the clinical management of migraine.

Results:
Calcitonin gene-related peptide, Pituitary adenylate cyclase-activating polypeptide (PACAP),
NOD-like receptor Protein (NLRP3), Serotonin, and some other neuroinflammatory biomarkers
are collectively responsible for the cerebral blood vessel dilation and involved in the nociceptive
pain which leads to migraine attack.

Conclusion:
Migraine biomarkers such as CGRP, PACAP, NLRP3, Nitric oxide synthase, MMP9,
and Serotonin could be targets for developing drugs. Present marketed medications temporarily
reduce symptoms and pain and have serious cardiovascular side effects. It is suggested that herbal
treatment may help prevent migraine attacks without adverse effects. Natural biomolecules that
may give better treatment than the present marketed medication and full fledge research should be
carried out with natural biomarkers by the Network Pharmacological approach.
Targets and Mechanisms of Resveratrol against Endothelial-Mesenchymal Transition in Atherosclerosis: A Network Pharmacology Analysis Combined with In vivo Experiments
Authors: Gao Xin , Man Xiao-Juan , He Bo , Xiang Juan , Chen Jin-Song 
Published: July 2023

Background:
Atherosclerosis (AS) is a chronic inflammatory disease characterized by plaque formation and endothelial dysfunction. Under pro-inflammatory conditions, the endothelial-mesenchymal transition (EndMT) plays an important role in the pathogenesis of AS. Resveratrol (RES) is a natural polyphenol in traditional Chinese medicines, which has been proven to possess anti-AS effects. However, the mechanism of RES treating AS through EndMT is not clear at present.

Methods:
RES targets were screened using databases such as SwissTargetPrediction and TargetNet, and AS and EndMT targets were searched using databases such as OMIM and DisGeNET. With the help of Venny 2.1, the key targets were selected by intersection. Next, the protein-protein interaction (PPI) network was constructed through the STRING 11.0 platform and Cytoscape software; gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotations were performed using DAVID. Further, Cytoscape was used to construct a drug-component-gene target-pathway network diagram to identify the core components and genes. Subsequently, an AS rat model was established. The blood lipid level of rats was detected by an automatic biochemical analyzer, and the expression level of the target protein was measured by western blotting.

Results:
Through network pharmacology analysis, 37 potential targets for RES treating AS and EndMT were identified, and the core targets for RES treating AS consisted of AKT1, TNF, MIMP9, and PPARG. GO enrichment analysis indicated that the treatment of AS with RES mainly involved the migration and proliferation of epithelial and endothelial cells. The KEGG pathway enrichment analysis revealed that the enrichment of TNF and Rap1 signaling pathways was most significant. Besides, RES effectively reduced the levels of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in the serum of AS rats, increased the level of high-density lipoprotein cholesterol (HDL-C), and significantly cut down the atherosclerosis index (AI). Twist1, calponin, α-SMA and VE-cadherin were considered as EndMT indexes. The results of the western blot demonstrated that the protein levels of Twist1, calponin and α-SMA were significantly decreased, while the protein expression level of VE-cadherin was notably increased in rats treated with RES. Moreover, RES could also reduce the expression levels of Rap1 and Epac1 proteins.

Conclusion:
RES is an effective anti-AS drug. Briefly, RES can effectively improve the blood lipid level of AS patients, regulate the expression of EndMT-related proteins, and alleviate the dysfunction of endothelial cells. Notably, the functions of RES are closely associated with the EPAC1-Rap1 pathway.
Curcumin-Enclosed Nanoparticles for Cancer Therapy
Authors: Rajput Shivam , Sharma Pramod Kumar , Malviya Rishabha , Kaushik Niranjan 
Published: July 2023

Abstract:
Cancer is the greatest cause of mortality worldwide, and it is distinguished by the unrestrained
proliferation of a group of aberrant cells, the random division of cells, and the invasiveness
of genetically organized cells. At present, there are various strategies for curing of cancer-based on
the type & severity. In the earlier two decades, curcumin has received huge attention in pharmacological,
biological, and nutraceutical research. In addition to triggering apoptosis in cancer cells,
curcumin also inhibits cancer cell invasion and proliferation by stifling cellular signaling pathways.
The lower water solubility of curcumin decreases the oral bioavailability, absorption into the systemic
circulation, and chemical stability and finally bound the activity of curcumin as an anticancer
agent. The pharmacology of curcumin, as well as its derivatives with relation to its anticancer potential,
primary modes of action, & cellular target, has been summarised in this article along with a
list of the numerous curcumin enclosing nanoformulations. Multiple methods of administration
have been developed for curcumin to boost its specificity. Encapsulation and other formulation
processing techniques have been found to enhance both the solubility and bioavailability of curcumin.
The nanoparticles' size, shape, surface characteristics, and targeting ligand are all factors that
nanoformulation designers must think about when working to increase the efficacy and cellular
targeting of anticancer treatments.
A Progressive Stratagem Outline on Diverse Dermatological Clays
Authors: Pal Rashmi , Pal Yogendra , Kumar Merugumolu Vijay , Katiyar Deepti , Punniyakotti Saranya 
Published: July 2023

Abstract:
For a very long time, clay has been widely utilized in cosmetics, and it is still one of the
most widely used components today. There is clay for every skincare issue and problem, including
dryness, irritation, sunburn, and oiliness. Finding the appropriate clay for the skin's type, texture, and
needs is the primary consideration. The current effort attempts to compile knowledge on the many
dermatological types of clay that are naturally present, their composition, and various views regarding
the care, skin nourishment, and benefits needed to suit the various needs of various skin types. The
present work aims to gather the information available on the different types of dermatological clays
present naturally, their composition, and different perspectives regarding the care and skin nourishment,
and their benefits required to suit different needs of different skin types.
Capparis spinosa Promoted BDNF and Antioxidant Enzyme Levels to
Protect Against Learning and Memory Deficits Induced by Scopolamine
Authors: Hosseini Mahmoud , Mansouritorghabeh Fatemeh , Beheshti Farimah , Shahidpour Fatemeh , Forouzanfar Fatemeh , Rajabian Arezoo 
Published: July 2023

Background:
Alzheimer's disease (AD) is a major neurodegenerative disorder with
multiple manifestations, including oxidative stress, brain-derived neurotrophic factor (BDNF) depletion,
and cholinergic dysfunction. Capparis spinosa (C. spinosa) is identified as a potential
source of nutrition for alleviating various ailments. The current study assessed the ameliorating
properties of C. spinosa hydroethanolic extract on memory dysfunction and the possible roles of
oxidative stress and BDNF in the scopolamine (Scop)-treated rats.

Methods:
Forty male Wistar rats were divided into the following four groups: Control, Scop (2
mg/kg, intraperitoneal injection (i.p.)), Scop + C. spinosa 150, and Scop + C. spinosa 300 groups.
The rats were given C. spinosa extract (150 or 300 mg/kg, oral) for 3 weeks. During the third
week, Passive Avoidance (PA) and Morris Water Maze (MWM) tests were done to assess
memory and learning performance. Finally, oxidative stress markers and BDNF in the brain tissue
were evaluated.

Results:
Scop injection was associated with a significant increase in the time latency and travelled
distance to reach the platform during the learning phase of MWM In the probe test, the Scoptreated
rats showed a lower time and distance in the target area. Furthermore, Scop injection significantly
decreased the latency to enter the dark while increasing the dark time and the frequency
of entries to the dark zone of the PA task. C. spinosa extract effectively reversed the behavioural
changes induced by Scop. Treatment with the extract also significantly increased the levels of superoxide
dismutase, catalase, thiols, and BDNF, while decreasing malondialdehyde production in
the brains of the Scop-injured rats.

Conclusion:
C. spinosa hydroethanolic extract successfully ameliorated Scop-induced memory
impairment by modifying BDNF and oxidative stress markers in the brain of amnesic rats.
Beetroot Bioactive and its Associated Health Benefits: Considerations for
Utilization of Beetroot in Value-added Products
Authors: Narayanan Meghana Valiyarayil , Rasane Prasad , Singh Jyoti , Kaur Sawinder , Avinashe Harshal , Gunjal Mahendra , Kaur Jaspreet , Bhadariya Vishesh 
Published: July 2023

Background:
Beetroot is a remarkable source of nutrients needed for the improvement
of human health. This paper presents a general overview of beetroot, its bioactive compounds,
and its valorization.

Objective:
The study aimed to understand and review the various beetroot bioactive compounds
and their utilization in value-added products.

Methods:
The findings and data provided in this review are based on the available research investigations
and authorized articles.

Result:
Beetroot is a reliable source of a cluster of bioactive compounds, such as betalains,
ascorbic acid, phenolic compounds, carotenoids, and nitrates, which have brought it into the
spotlight for the preparation of various value-added products for daily consumption for better
health. These beneficial compounds show a wide range of health benefits, such as antiinflammatory
activity, anti-oxidant activity, anti-anemic activity, and cancer chemopreventive
activity.

Conclusion:
This paper has reviewed the studies focused on the utilization of beetroot concerning
its varied composition of nutraceutical components. This review briefly accounts for the different
bioactive compound extraction methods that are immensely helpful in the food and health
industries. The advantages and disadvantages of these extractions are also taken into consideration.
There is a wide range of value-added products currently in the market that are generated
from the addition of beetroot for the improvement of nutritional as well as sensory attributes of
the final products.
The Use of ChatGPT for Education Modules on Integrated Pharmacotherapy of Infectious Disease: Educators' Perspectives
Authors: Al-Worafi Yaser Mohammed , Goh Khang Wen , Hermansyah Andi , Tan Ching Siang , Ming Long Chiau 
Published: July 2023

Background
Artificial Intelligence (AI) plays an important role in many fields, including medical education, practice, and research. Many medical educators started using ChatGPT at the end of 2022 for many purposes.

Objective
The aim of this study was to explore the potential uses, benefits, and risks of using ChatGPT in education modules on integrated pharmacotherapy of infectious disease.

Methods
A content analysis was conducted to investigate the applications of ChatGPT in education modules on integrated pharmacotherapy of infectious disease. Questions pertaining to curriculum development, syllabus design, lecture note preparation, and examination construction were posed during data collection. Three experienced professors rated the appropriateness and precision of the answers provided by ChatGPT. The consensus rating was considered. The professors also discussed the prospective applications, benefits, and risks of ChatGPT in this educational setting.

Results
ChatGPT demonstrated the ability to contribute to various aspects of curriculum design, with ratings ranging from 50% to 92% for appropriateness and accuracy. However, there were limitations and risks associated with its use, including incomplete syllabi, the absence of essential learning objectives, and the inability to design valid questionnaires and qualitative studies. It was suggested that educators use ChatGPT as a resource rather than relying primarily on its output. There are recommendations for effectively incorporating ChatGPT into the curriculum of the education modules on integrated pharmacotherapy of infectious disease.

Conclusions
Medical and health sciences educators can use ChatGPT as a guide in many aspects related to the development of the curriculum of the education modules on integrated pharmacotherapy of infectious disease, syllabus design, lecture notes preparation, and examination preparation with caution.