bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authigenic haematite may exhibit similar rock magnetic properties to detrital haematite: a case study from early Triassic red beds in North China
Authors: Han Fei , Zheng Zhong , Jiang Zhaoxia , Qin Huafeng , Fan Longgang , Wang Huapei 
Published: January 2025

SUMMARY
Haematite-bearing red beds are widespread across the Earth and play a pivotal role in palaeomagnetic studies. However, chemical remanent magnetization (CRM) typically associated with authigenic haematite is not fully understood, which precludes more accurate interpretations of natural remanent magnetization (NRM) in red beds. Here, we use electron microscopy, rock magnetism and palaeomagnetism to investigate authigenic haematite in early Triassic red beds in North China. Our findings reveal that the biotite-hosted haematite grains with grain sizes of several to tens of microns carry a significant portion of the NRM in these sedimentary rocks. We propose that these authigenic haematite particles primarily form during the early stages of diagenesis process. This authigenic haematite's growth is controlled by the crystal structure of the host biotite. Furthermore, this authigenic haematite displays high coercivity (&gt; 100 mT) and high unblocking temperature (&gt; 650 °C), comparable to that of typical detrital haematite (100–1000 mT, &gt; 650 °C), which is usually the primary carrier of detrital remanent magnetization (DRM) in such red beds. This study highlights the significance of combining mineralogical analysis with rock magnetism and palaeomagnetism to differentiate between CRM and DRM and thereby identify the primary NRM component within red beds. We hypothesize that the abundant iron supplied by biotite promotes the growth of authigenic haematite. This study illustrates the need to use caution when studying sedimentary NRM, particularly in rocks from source areas containing acidic igneous and metamorphic rocks (e.g. granite, diorite and biotite gneiss) that contain a large proportion of iron-bearing minerals, such as the biotite observed in this study.
Genome-wide association studies to assess genetic factors controlling cucumber resistance to CABYV and CMV in crop fields and the attractiveness for their Aphis gossypii vector”
Authors: Monnot Séverine , Ravineau Anaïs , Coindre Eva , Mistral Pascale , Leyre Karine , Chadœuf Joel , Cantet Melissa , Boissot Nathalie 
Published: January 2025

Abstract
Cucumber crops face high pressure from pathogens, including various viral species. Mapping quantitative trait loci (QTL) for vegetable resistance to viruses has primarily been conducted after mechanical inoculation in controlled environments, but not in crop field conditions. Moreover, viruses which cannot be mechanically inoculated, e.g. the cucurbit aphid-borne yellows virus (CABYV), have been overlooked in resistance studies. Here we aimed to identify QTLs reducing epidemics of two prevalent cucumber viruses: CABYV and the cucumber mosaic virus (CMV). We evaluated the resistance of 256 elite cucumber lines and landraces in crop field conditions by screening for the presence of both viruses six-times during the season. We mapped twelve QTLs reducing CABYV epidemics and seven QTLs reducing CMV epidemics by combining multi-loci genome-wide association studies (GWAS) and local score approach analyses. We also examined the attractiveness of this cucumber panel for Aphis gossypii, a major cucumber virus vector. We identified five QTLs that reduced the attractiveness, including one co-localizing with a QTL reducing CABYV epidemics. Interestingly, some accessions deemed CMV-resistant after mechanical inoculation in controlled environments showed high infection rates in crop field conditions. Only one QTL for CMV resistance was detected in both conditions, indicating that these phenotypes are regulated by independent QTLs. Local linkage disequilibrium study findings suggested that certain QTLs reducing epidemics were introduced early into elite lines through serendipity or selection. QTLs could be pyramided with other low effect QTLs through genomic selection to obtain cucumber cultivars with enhanced field resistance to viruses.
Serum free 25(OH)D concentrations and cardiovascular disease, heart failure, kidney function decline, and fracture: the health, aging, and body composition study
Authors: Cheng Jonathan H , Hoofnagle Andrew N , Katz Ronit , Kritchevsky Stephen B , Shlipak Michael G , Sarnak Mark J , Ix Joachim H , Ginsberg Charles 
Published: January 2025

Abstract
Vitamin D deficiency is common across the world. However, the standard clinical biomarker for vitamin D, 25OHD, may be a poor marker of vitamin D status, as most of circulating vitamin D is protein bound and not bioavailable. Free (unbound) vitamin D may therefore be a better marker of vitamin D status. We evaluated the relationship of free vitamin D with incident cardiovascular disease (CVD), heart failure (HF), kidney function decline (KFD) and fracture, among 786 participants in the Health Aging and body composition study. We used sequential models to assess hazard ratios (HRs) of each outcome that adjusted for age, sex, race, season of blood sampling, and study site, kidney function, serum calcium and phosphate, FGF 23, PTH, BMI, and vitamin D supplementation. The mean age of the 786 participants was 75 ± 3 yr, 53% were women, and 40% were Black. The median free vitamin D concentration was 5.3 (interquartile range 4.1-6.7) pg/mL. There were 157 cases of incident CVD, 123 cases of incident HF, 382 cases of incident KFD, and 178 fractures over 11 yr of follow-up. In fully adjusted models, a 2-fold greater free vitamin D was associated with lower risk of incident HF [HR 0.75, 95%CI,0.58-0.96 ] and greater risk KFD [1.25(1.03-1.52)]. We found no association between free vitamin D and incident CVD or fracture. We did not find evidence that free vitamin D was a superior marker of clinical outcomes compared to total 25OHD alone. Further studies are needed to elucidate the relationship of free vitamin D with clinical outcomes.
An Information-Theoretic Asset Pricing Model
Authors: Ghosh Anisha , Julliard Christian , Taylor Alex P 
Published: January 2025

Abstract
We show that a non-parametric estimate of the pricing kernel, extracted using an information-theoretic approach, delivers smaller out-of-sample pricing errors and a better cross-sectional fit than leading multi-factor models. The information stochastic discount factor (I-SDF) identifies sources of risk not captured by standard factors, generating very large annual alphas (20–37%) and Sharpe ratio (1.1). The I-SDF extracted from a wide cross-section of equity portfolios is highly positively skewed and leptokurtic, and implies that about a third of the observed risk premia represent compensation for 2.5% tail events. The I-SDF offers a powerful benchmark relative to which competing theories and investment strategies can be evaluated.
PLA2R autoantibodies, a multifaceted biomarker in nephrotic syndrome and membranous nephropathy
Authors: Ragy Omar , Abass Wessam , Kanigicherla Durga Anil K , Shinkins Bethany , Bestall Janine , King Natalie , Brenchley Paul , Smith Alison , Hamilton Patrick 
Published: January 2025

Abstract

Background and hypothesis
The PLA2R antibody test is a valuable first-line diagnostic tool for primary membranous nephropathy (MN), helping to identify PLA2R-related MN and potentially eliminating the need for a kidney biopsy in some individuals. By reducing the reliance on biopsies, the test streamlines diagnosis and improves patient care. However, determining the optimal PLA2R measurement method and cut-off is critical to maximising the benefits of the test and minimising any harms.

Methods
A systematic review and meta-analysis were performed to evaluate serum- and urine-based biomarkers for distinguishing between PLA2R-related MN and non-PLA2R MN. Searches were conducted in databases including Medline, Embase, Cochrane Library, Scopus, Web of Science, INAHTA, and ClinicalTrials.gov. The methodology followed Cochrane-recommended guidelines for systematic reviews and meta-analyses, and the QUADAS-2 tool was utilised to assess the overall risk of bias.

Results
Ninety one studies met the eligibility criteria for inclusion in the review. Of these, 38 studies reporting the accuracy of the PLA2R-Ab test using the EUROIMMUN ELISA method and 27 using the EUROIMMUN IF method were suitable for meta-analysis.. The pooled sensitivity and specificity of EUROIMMUN ELISA at a cut-off value of 20 RU/ml were 0.64 (95% CI: 0.56, 0.72) and 94.7% (95% CI: 90.5 - 97.1%),  respectively. The pooled sensitivity and specificity of EUROIMMUN IF at a threshold of 1:10 was 0.69 (95% CI: 0.637 – 0.739) and 0.98 (95% CI: 0.931 – 0.994), respectively. Risk of bias was higher for studies evaluating the IF compared to ELISA test. We also explored whether the timing of the index test had an impact on the pooled diagnostic accuracy results; no significant differences were found.

Conclusions
By evaluating the specificity and sensitivity of EUROIMMUN ELISA PLA2R-Ab and immunofluorescence (IF), we demonstrate that at ELISA levels ≥20 RU/mL, alongside thorough secondary screening, a kidney biopsy may be unnecessary. However, lower or negative levels still warrant a biopsy.
Electrochemical dendrite management via voltage-controlled rearrangement
Authors: Liu Zhexuan , Wu Xinru , Xiao Xiao , Xiao Zhiqiang , Fu Qingjin , Zheng Zhiyang , Zhong Xiongwei , Zheng Fengyi , Zhou Guangmin 
Published: January 2025

Abstract
The pursuit of advanced energy storage solutions has highlighted the potential of rechargeable batteries with metal anodes due to their high specific capacities and low redox potentials. However, the formation of metal dendrites remains a critical challenge, compromising both safety and operational stability. For zinc-based batteries (ZBs), traditional methods to suppress dendrite growth have shown limited success and often entail performance compromise. Here, we propose a novel strategy termed dendrite rearrangement (DR) that leverages the electrochemical self-discharge process to controllably address the dendrite issues. By temporarily increasing the input voltage within a single cycle, this strategy resets the cell stability without precipitating undesirable side reactions during normal operation. This pioneering technique extends operational lifespans to over three times their original duration, facilitating 80,000 cycles for Zn-ion hybrid capacitors and 3,000 hours for Zn symmetrical cells. Even in scaled-up pouch cells, Ah-level symmetrical cells demonstrate a cumulative capacity nearing 200,000 mAh, significantly surpassing that of reported metal symmetrical cells. Additionally, the electrolytic Zn-MnO2 battery demonstrates a high capacity approaching 10 Ah, setting a new benchmark among reported ZB devices. These results mark a significant advance towards resolving dendrite-related issues in metal anode batteries, paving the way for their sustainable development and potential commercialization.
Knee Anterior Laxity and Graft Maturation After Transphyseal Anterior Cruciate Ligament Reconstruction
Authors: Accadbled Franck , Lescot Timothé , Nicolaou Nicolas , Doumerc Jeremy , Cavaignac Etienne , Flumian Clara , Maupoint Estelle , Sales de Gauzy Jérôme 
Published: January 2025

Background:
The failure rate of anterior cruciate ligament (ACL) reconstruction in children and adolescents is a significant concern. Of the multitude of clinical factors that contribute to this risk, delayed maturation and graft laxity are potentially related and modifiable elements. The aim was to investigate knee anterior laxity and graft maturation in children and adolescents. The ligamentization of the graft may be correlated with the residual laxity.

Methods:
A single-center prospective study included skeletally immature patients treated with transphyseal ACL reconstruction using semitendinosus tendon autograft from 2017 to 2019. Participants were evaluated on 4 occasions: preoperatively, then at 6, 12, and 24 months with instrumented laximetry and MRI to analyze graft maturation according to the Signal-to-noise Quotient (SNQ) and Howell classification.

Results:
A total of 50 patients (33 boys and 17 girls), with a mean age of 13.2 years (range, 9 to 16) at the time of surgery, were included. Mean side-to-side knee anterior laxity decreased from 2.78 mm preoperatively to 1.59, 1.80, and 1.30 mm (at 6, 12, and 24 mo follow-up, respectively), P<0.05. No statistical difference was noted according to the follow-up or sex. SNQ was unchanged between 6 and 12 months, but a significant difference was demonstrated between 12 months and 24 months (P=0.008). There was no statistical correlation between laximetry and graft maturation.

Conclusions:
ACL graft ligamentization is delayed in children and adolescents and only occurs between 12 and 24 months postoperatively. Residual laximetry and MRI signal of the graft may become one of the multiple elements upon which to base the decision to return to sport.
Pediatric Bone Sarcoma Biopsy Tract Excision: Is it Safe to Resect Separately?
Authors: Eckhoff Michael D. , Strub Daryn R. , Utset-Ward Thomas J. , Wells Matthew E. , Scharschmidt Thomas J. 
Published: January 2025

Background﻿:
Biopsy is an essential part of proper diagnostic workup in pediatric bone sarcomas impacting surgical planning, chemotherapeutic treatments, and prognostic determination. Two main biopsy techniques are currently used: closed biopsy (core needle or fine needle aspiration) and open biopsy. Historical oncologic teaching is for resection of the biopsy tract with the tumor specimen due to the theoretical risk for biopsy tract tumor contamination; however, this can restrict surgical planning and increase morbidity. This study evaluates oncologic outcomes at this institution, comparing open versus closed biopsy, and biopsy tract resection with or separate from the main tumor resection.

Methods:
Retrospective review of a single institution of all patients treated for bone sarcomas from 2006 through December 2021. Patient and tumor characteristics, biopsy technique, biopsy resection method, and oncologic outcomes were collected. Subgroup statistical analysis was performed comparing closed biopsy and open biopsy techniques, and biopsy tract resection with the main tumor or separately.

Results:
A total of 73 patients met the inclusion criteria, including 48 (65.8%) open biopsies and 25 closed biopsies [23 (31.5%) core needle biopsies and 2 (2.7%) fine needle aspirations]. Biopsy tract resection was performed with the main tumor in 36 (49.3%), separate in 37 (50.7%). There were no statistical differences in local recurrence, disease-free survival, metastatic progression, or overall survival between biopsy methodology analysis and biopsy tract removal methods.

Conclusion:
This study demonstrates the safety of both approaches for obtaining diagnostic tissues with low rates of biopsy tract seeding in both methods. In addition, it demonstrates that there is no difference in local recurrence, disease-free survival, metastatic progression, or overall survival between biopsy tract resection with or separate from the main tumor. Definitive surgical plan should not vary based on biopsy technique and biopsy tract management, but rather patient, tumor, institutional, and surgeon factors.

Level of Evidence:
Level III—retrospective chart review. The study was started after the patients were diagnosed and treated.
Rhinoplasty Septal Cartilage Harvest and Reconstruction: The 4 Clicks
Authors: Gimenez Alejandro R. , Borab Zachary , Fisher Sean , Rohrich Rod J. 
Published: January 2025

Summary:
Successful rhinoplasty relies on a deep understanding of nasal anatomy and precise nasal tip control for lasting functional and aesthetic outcomes. Structural grafts, like septal extension grafts, are instrumental in maintaining tip position and projection with minimal long-term changes. This article details a systematic technique to harvest septal cartilage that maximizes graft material and allows for effective septal deviation correction.
Monitoring response to prone positioning
Authors: Guérin Claude , Grasselli Giacomo 
Published: January 2025

Purpose of review
The increasing use of prone position, in intubated patients with acute respiratory distress syndrome as well as in patients with acute hypoxemic respiratory failure receiving noninvasive respiratory support, mandates a better definition and monitoring of the response to the manoeuvre. This review will first discuss the definition of the response to prone positioning, which is still largely based on its effect on oxygenation. We will then address monitoring respiratory and hemodynamic responses to prone positioning in intubated patients. Finally, we will also discuss monitoring inspiratory effort in nonintubated patients with acute hypoxemic respiratory failure who breathe spontaneously and receive noninvasive respiratory support

Recent findings
The response to prone positioning should be enriched by data pertaining to lung protection beyond oxygenation. These include trans-pulmonary pressure, driving pressure, mechanical power, distribution of aeration and ventilation and assessment of potential for lung recruitment before the pronation.

Summary
The implications of present findings are to: better select those patients who will benefit from proning in physiological terms, better indicate the timing of onset and end of the sessions, and strengthen the relationship between physiological response and patient outcome.
Natural history of recovery and long-term outcome in critically ill patients with brain injury
Authors: Kanny Samantha , Giacino Joseph T. 
Published: January 2025

Purpose of review
To increase knowledge of the natural history of recovery and long-term outcome following severe traumatic brain injury (sTBI).

Recent findings
Recovery of consciousness and complex behaviors that presage subsequent functional recovery frequently occurs well beyond the first 7 days after injury, which is typically the time period widely used in the ICU for prognostic decision-making and establishing goals of care for. Similarly, recovery of functional independence occurs between 1 and 10 years postinjury in a substantial proportion of patients who do not recover command-following during the acute hospitalization. Data from large, multicenter studies that systematically conduct long-term follow-up with well validated measures consistently indicate that the most common trajectory of recovery after 1 year postinjury is characterized by changes, not stability, in functional status.

Summary
Evidence from large multicenter studies with well characterized samples focusing on recovery trajectories beyond 1 year postinjury challenge conventional beliefs about outcome after sTBI. Signs of consciousness frequently emerge following discharge from the ICU setting and prediction of death and dependency within the first few weeks after injury is unreliable. Clinician knowledge of the frequency and time course to recovery of key behavioral milestones is central to evidence-based prognostic counseling.
Code Milk
Authors: Goli Shubhi G. , Sebok-Syer Stefanie S. , Halpern-Felsher Bonnie , Goyal Shuchi , Wang N. Ewen , Fang Andrea 
Published: January 2025

Objectives:
The aim of the study is to characterize the lactation goals and practice of pediatric emergency medicine (PEM) fellows and to identify areas of improvement related to 1) policy awareness, 2) departmental culture and accommodations, and 3) lactation space and time.

Methods:
This study is a national, cross-sectional survey study of PEM fellows and program directors (PDs). Two surveys were developed via iterative review and distributed by the PEM-PD Survey Committee. Responses were collected anonymously via the Qualtrics survey platform. Data were summarized using descriptive statistics.

Results:
Survey responses from 60 PEM PDs (71%, 60/84) estimated that 67% (310/461) of their fellows had the ability to lactate. One hundred fifteen study-eligible fellows (37%) completed the survey. Most fellows (57%, 66/115) reported having lactated or expected to lactate during fellowship. Fellows reported an ideal lactation time of 11.5 months. Sixty-two percent (8/13) met their lactation goal and 42% (22/66) did not or did not know if they would meet their goal. Forty-three percent (50/115) of fellows and 57% (34/60) of PDs were aware of workplace lactation policies. Sixty-one percent (38/62) of fellows discussed a lactation plan with their PDs and 18% (7/39) reported their rotations upon returning to work were scheduled with lactation needs in mind. A dedicated lactation space was available to 67% (43/64) of fellows but used by 29% (11/28). Fellows lactated on average twice during an 8-hour shift, spending 7 minutes walking to and from their chosen lactation space and 21-minute pumping per session.

Conclusions:
PEM fellows are likely to have lactation needs during fellowship but receive inconsistent support from their programs. Based on our findings, we advocate for the creation of more visible and PEM-specific workplace lactation policies, planning with PDs pre-return to work, and improved availability and usability of designated lactation spaces. Further optimization may help support PEM fellows' personal, clinical, and academic productivity.
Fibromyalgia syndrome—a bodily distress disorder/somatic symptom disorder?
Authors: Häuser Winfried , Fitzcharles Mary-Ann , Henningsen Peter 
Published: January 2025

Abstract

Introduction:
The debate addressing the classification of chronic widespread pain as a physical disorder (fibromyalgia syndrome) [FMS] or a somatoform disorder according to psychiatric classification systems has continued for decades.

Objectives:
The review aims to line out the new perspectives introduced by the 11th version of the International Classification of Diseases (ICD 11) of the World Health Organization (WHO).

Methods:
Critical review of the classification criteria of fibromyalgia syndrome and bodily distress disorder in ICD 11.

Results:
Fibromyalgia syndrome has been eliminated from the chapter of diseases of the musculoskeletal system and is now included in a chapter “Symptoms, signs, clinical forms, and abnormal clinical and laboratory findings, not elsewhere classified“. Previously, the ICD-10 diagnosis of somatoform disorder was often used by mental health care disciplines instead of the label FMS. Somatoform disorders category has been eliminated as a diagnostic category in the ICD-11 and the 5th version Diagnostic and Statistical Manual of Mental Disorders of the American Psychiatric Association (APA) and has been replaced with the new categories of bodily distress disorder (BDD) and somatic symptom disorder (SSD) respectively. For diagnosis, these latter mental disorders require at least one distressing somatic symptom (e.g. pain) plus positive psychobehavioral criteria, namely „excessive thoughts, feelings, or behaviours related to the somatic symptoms or associated health concerns“, without the condition that distressing somatic symptoms have to be medically unexplained.

Conclusion:
We argue that the psychobehavioral criteria of BDD/SSD are imprecisely defined and can be misinterpreted as for „Excessive health concerns“ which may occur due to the many uncertainties surrounding FMS or „Excessive time devoted to the symptoms“ which may be related to patient self-management strategies.