bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impactos das tecnologias digitais no ensino de enfermagem: caminhos para inovação educacional
Authors: De Paula Alves Costa da Silva Patrícia , Silvio Cavalcante Pimentel Fernando , Kellya Holanda da Silva Meirielly , Fernandha Santos Santana Marya 
Published: April 2023

Descrição: Trata-se de Revisão Sistemática de Literatura (RSL). Objetivo: Analisar os impactos da incorporação das Tecnologias Digitais (TD) no Ensino de Enfermagem, considerando as constantes evoluções que cercam os segmentos da sociedade. Metodologia: Optou-se pela Revisão Sistemática de Literatura (RSL) em bases de dados indexadas, acessando estudos nacionais publicados entre os anos de 2016 e 2021, com as recomendações metodológicas Preferred Reporting Items for Systematic Reviews and Meta-Analyses – PRISMA. Resultados: Foram selecionados 21 artigos, sendo a maioria publicados nos anos de 2018 e 2021. Da totalidade dos artigos emanaram duas categorias temáticas, sendo a primeira versando sobre os impactos dos principais tipos de TD incorporadas ao Ensino de Enfermagem contemporânea como os Ambientes Virtuais de Aprendizagem na plataforma Moodle, realidade virtual utilizando software multimídia, videoaula, aplicativos digitais, hipermídia para o ensino da sistematização de enfermagem, teleconferências e videoconferências A segunda categoria temática elegeu os debates sobre a revolução que as TD estão proporcionando no processo de ensino-aprendizagem em enfermagem, evidenciando que houve melhoria no resultado do aprendizado de estudantes. Conclusão: Salienta-se que é fundamental considerar que o universo digital tecnológico pode influenciar na motivação, reforçando e contribuindo para melhorar o desempenho no aprendizado dos estudantes de graduação em enfermagem atualmente.

Descritores: Enfermagem; Ensino; Tecnologia; Educação; Sociedade.
Implementasi SWOT Digital Marketing Dalam Meningkatkan Penjualan “Show Bakso Malang” di Era New Normal
Authors: Irawan Budi Prasetyo  , Rina Irawati  
Published: April 2023

Abstract
The purpose of this study is to determine the internal environmental factors and external environmental factors that are strengths, weaknesses, opportunities and threats in digital marketing, as well as to identify strategies that can be done to increase sales. The object of the research is the Bakso Show, which is a culinary SME that has just been established in Malang. The type of research is descriptive qualitative research with SWOT analysis technique. The technique of checking the validity of the data is using the triangulation technique. The IFAS weighting result is 0.578 and the EFAS weighting result is 0.4625. Both have positive values. The position of Show Bakso’s SWOT is in quadrant 1, namely Progressive. SWOT analysis produces four strategic perspectives, namely SO (Strength-Opportunities), WO (Weakness-Opportunities), ST (Strength-Threats), and WT (Weakness-Threats). Generally, there are 15 digital marketing strategies that can be implemented to increase sales at Show Bakso.
Analisis Kontribusi dan Efektivitas Pendapatan Asli Daerah Kabupaten Manggarai Tahun 2017-2019
Authors: Redemptus Ntangis Holymayor  , Yulia Setyarini  
Published: April 2023

The Republic of Indonesia is the largest archipelagic country in the world, which consists of various provinces, cities and regencie. Based on Law Number 12 of 2008 concerning the Second Amendment to Law Number 32 of 2004 concerning Regional Government and Law Number 33 of 2004 concerning Financial Balance between the Central Government and Regional Government, the administration of regional government is carried out by granting the broadest authority. -the breadth, accompanied by the granting of rights and obligations to implement regional autonomy in the unit of the state administration system. Each head of government can manage regional income effectively and efficiently in service and contribution to the community. The aim is to analyze the contribution and effectiveness of the Regional Original Revenue (PAD) of Manggarai Regency in 2017-2019.
The results of this study show that in 2017-2019 a very good level of contribution is found in the Manggarai Regency's Original Regional Revenue, namely Other Legitimate Regional Original Income, in 2017 it is 76.02%, in 2018 it is 64.99%, and in 2019 of 69.59%. The very effective level of effectiveness is Other Legitimate Local Revenue, where in 2017 it was 102.23%, in 2018 it was 113.11%, and in 2019 it was 137.57%.
Endoscopic ultrasonic resection of calcified tumor of the third ventricle
Authors: Spennato Pietro , Onorini Nicola , Vitulli Francesca , Imperato Alessia , De Martino Lucia , Ruggiero Claudio , Cinalli Giuseppe 
Published: April 2023

In this video, the authors present ultrasonic resection of calcified tumor of the third ventricle in a 12-year-old boy. He presented to the emergency department with a 1-week history of headache, drowsiness, and bilateral papilledema. Despite extensive calcification visible on a CT scan, a minimally invasive pure endoscopic approach was chosen. The use of an ultrasonic aspirator allows fast and safe removal of the tumor. The histological diagnosis was a low-grade glioneuronal tumor. In conclusion, the endoscopic ultrasonic aspirator is a useful tool to resect tumors in the ventricular system. The presence of calcifications within the tumor does not contraindicate an endoscopic approach.
The video can be found here: https://stream.cadmore.media/r10.3171/2023.1.FOCVID22143
Feasibility of extended transforaminal approach (medial subchoroid) for resection of a benign aqueductal tumor in a patient with type 1 neurofibromatosis
Authors: Narro-Donate Jose M. , Guil-Ibañez Jose J. , Castelló-Ruiz Maria José , García-Pérez Fernando , Urreta-Juarez Gaizka , Masegosa-González José 
Published: April 2023

The extended transforaminal endoscopic approach allows visualization and manipulation of the third ventricle posterior structures in a safe and comfortable manner. The medial subchoroidal approach has been described as a feasible alternative to the classical transchoroidal approach.
In this video, the authors present the case of a 14-year-old male with a history of neurofibromatosis type 1 who was referred to our department after presenting with headaches and diplopia for 2 weeks. Suspecting an aqueduct tumor, the authors performed an endoscopic surgical procedure through a single approach with third cisternostomy and resection of the tumor that produced the stenosis.
The video can be found here: https://stream.cadmore.media/r10.3171/2023.1.FOCVID22155
Minimally invasive techniques: full endoscopic inferior parietal lobule approach for an endoventricular removal of a left trigone meningioma grade I
Authors: Gelmi Clarissa A. E. , Cecchini Giulio , Vitale Giovanni , Di Biase Francesco 
Published: April 2023

Intraventricular meningiomas are rare tumors, mainly localized in the lateral ventricle trigone. Several microscopic surgical approaches have been proposed according to the location of the tumors in the atrium. The authors present the case of a 68-year-old woman who had an increscent medically resistant headache with a left trigone meningioma. In the video, they demonstrate the four-hands surgical technique through a minimally invasive fully endoscopic retractor-less transcortical approach. They also discuss the background of these tumors and the technical nuances of the procedure, including the differences between an endoscopic surgical and a microsurgical one.
The video can be found here: https://stream.cadmore.media/r10.3171/2023.1.FOCVID2296
Stroke management and outcomes in low-income and lower-middle-income countries: a meta-analysis of 8535 patients
Authors: Aguirre Alexander O. , Rogers James L. , Reardon Taylor , Shlobin Nathan A. , Ballatori Alexander M. , Brown Nolan J. , Gendreau Julian , Shahrestani Shane 
Published: April 2023

OBJECTIVE
Strokes affect almost 13 million new people each year, and whereas the outcomes of stroke have improved over the past several decades in high-income countries, the same cannot be seen in low-income and lower-middle-income countries. This is the first study to identify the availability of diagnostic tools along with the rates of stroke mortality and other poststroke complications in low-income and lower-middle-income countries.

METHODS
A review of the literature was completed with a search of the MEDLINE, Embase, and Scopus databases, with adherence to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Studies were included if they reported any outcomes of stroke in low-income and lower-middle-income countries as designated by the World Bank classification. A meta-analysis calculating pooled prevalence rates of diagnostic characteristics and stroke outcomes was completed for all endpoint variables.

RESULTS
A total of 19 studies were included, of which 6 came from Ethiopia, 3 from Zambia, and 2 each from Tanzania and Iran. Single studies from Zimbabwe, Botswana, Senegal, Cameroon, Uganda, and Sierra Leone were included. A total of 5265 (61.7%) patients had an ischemic stroke, 2124 (24.9%) had hemorrhagic stroke, with the remaining 1146 (13.4%) having an unknown type. Among 6 studies the pooled percentage of patients presenting to hospital within 1 day was 48.37% (95% CI 38.59%–58.27%; I2 = 97.0%, p < 0.01). The pooled in-hospital mortality rate was 19.81% (95% CI 15.26%–25.31%; I2 = 91%, p < 0.01), but was higher in a hemorrhagic subgroup (27.07% [95% CI 22.52%–32.15%; I2 = 54%, p = 0.05]) when compared to an ischemic group (13.16% [95% CI 8.60%–19.62%; I2 = 87%, p < 0.01]). The 30-day pooled mortality rate was 23.24% (95% CI 14.17%–35.70%; I2 = 93%, p < 0.01). At 30 days, the functional independence (modified Rankin Scale score 0–2) pooled rate was 13.10% (95% CI 7.50%–21.89%; I2 = 82%, p < 0.01).

CONCLUSIONS
A severe healthcare disparity is present in low-income and lower-middle-income countries, where there is delayed diagnosis of strokes and increased rates of poor clinical outcomes for these patients.
Toward rational use of repeat imaging in children with mild traumatic brain injuries and intracranial injuries
Authors: Johnson Gabrielle W. , Greenberg Jacob K. , Hale Andrew T. , Ahluwalia Ranbir , Hill Madelyn , Belal Ahmed , Baygani Shawyon , Foraker Randi E. , Carpenter Christopher R. , Yan Yan , Ackerman Laurie L. , Noje Corina , Jackson Eric , Burns Erin C. , Sayama Christina M. , Selden Nathan R. , Vachhrajani Shobhan , Shannon Chevis N. , Kuppermann Nathan , Limbrick David D. 
Published: April 2023

OBJECTIVE
Limited evidence exists on the utility of repeat neuroimaging in children with mild traumatic brain injuries (mTBIs) and intracranial injuries (ICIs). Here, the authors identified factors associated with repeat neuroimaging and predictors of hemorrhage progression and/or neurosurgical intervention.

METHODS
The authors performed a multicenter, retrospective cohort study of children at four centers of the Pediatric TBI Research Consortium. All patients were ≤ 18 years and presented within 24 hours of injury with a Glasgow Coma Scale score of 13–15 and evidence of ICI on neuroimaging. The outcomes of interest were 1) whether patients underwent repeat neuroimaging during index admission, and 2) a composite outcome of progression of previously identified hemorrhage ≥ 25% and/or repeat imaging as an indication for subsequent neurosurgical intervention. The authors performed multivariable logistic regression and report odds ratios and 95% confidence intervals.

RESULTS
A total of 1324 patients met inclusion criteria; 41.3% of patients underwent repeat imaging. Repeat imaging was associated with clinical change in 4.8% of patients; the remainder of the imaging tests were for routine surveillance (90.9%) or of unclear prompting (4.4%). In 2.6% of patients, repeat imaging findings were reported as an indication for neurosurgical intervention. While many factors were associated with repeat neuroimaging, only epidural hematoma (OR 3.99, 95% CI 2.22–7.15), posttraumatic seizures (OR 2.95, 95% CI 1.22–7.41), and age ≥ 2 years (OR 2.25, 95% CI 1.16–4.36) were significant predictors of hemorrhage progression and/or neurosurgery. Of patients without any of these risk factors, none underwent neurosurgical intervention.

CONCLUSIONS
Repeat neuroimaging was commonly used but uncommonly associated with clinical deterioration. Although several factors were associated with repeat neuroimaging, only posttraumatic seizures, age ≥ 2 years, and epidural hematoma were significant predictors of hemorrhage progression and/or neurosurgery. These results provide the foundation for evidence-based repeat neuroimaging practices in children with mTBI and ICI.
Risk factors of intraoperative blood transfusion in pediatric craniotomy for intracranial tumor resection: a 10-year analysis
Authors: Sangtongjaraskul Sunisa , Sae-phua Vorrachai , Amornfa Jiraphorn , Tuchinda Lawan 
Published: April 2023

OBJECTIVE
A pediatric craniotomy for intracranial tumor removal brings both high bleeding and blood transfusion risks. The aim of this study was to identify the risk factors for intraoperative blood transfusion in this procedure. The secondary outcome was to investigate postoperative complications and clinical outcomes related to blood transfusion.

METHODS
A retrospective analysis was performed among children who underwent a craniotomy for brain tumor resection at a tertiary hospital over a 10-year period. The pre- and intraoperative variables were examined and compared between the transfusion and nontransfusion groups.

RESULTS
One hundred seventy-two patients (58%) received intraoperative blood transfusions among a total of 295 craniotomies in 284 children. Factors associated with blood transfusion were body weight ≤ 20 kg (adjusted odds ratio [AOR] 5.286, 95% confidence interval [CI] 2.892–9.661; p < 0.001), American Society of Anesthesiologists (ASA) physical status III–IV (AOR 6.860, 95% CI 1.434–32.811; p = 0.016), preoperative hemoglobin ≤ 11 g/dl (AOR 3.610, 95% CI 1.406–9.265; p = 0.008), tumor size ≥ 45 mm (AOR 2.117, 95% CI 1.214–3.693; p = 0.008), and duration of operation ≥ 6 hours (AOR 3.816, 95% CI 1.736–8.385; p = 0.001). Postoperative infection of other systems, other complications, duration of mechanical ventilation, and intensive care unit and hospital length of stay were found to be significantly higher in the transfusion group.

CONCLUSIONS
Lower body weight, higher ASA physical status, preoperative anemia, large tumor size, and prolonged duration of surgery were found to be significant factors for predicting intraoperative blood transfusion in pediatric craniotomy. The identification and modification of risks from intraoperative blood transfusion can be beneficial in reducing the probability of transfusion and improving allocation efficiency of limited blood component resources.
Le long règne des gangs
Authors: Alcin Jeffton , Alphonse Ritchy , Blanchard Charles , Enezer John Mekinson 
Published: April 2023

Chaos et inexistence de l’État ont cours en Haïti, livré au joug des bandes criminelles. Bien loin d’y être un phénomène nouveau, le gangstérisme s’inscrit depuis l’origine dans l’histoire du pays. Quelles réponses y apporter ?
Retour sur le Plan
Authors: Laffargue Jean-Pierre , Morin Pierre 
Published: April 2023

Ce texte a pour but de rappeler ce que tenta d’apporter le Plan pendant près de 40 ans, à partir de 1945, aux politiques économiques, structurelles surtout, en mettant l’accent sur sa pensée économique et ses apports méthodologiques. Nous partons d'une présentation en quatre points de Pierre Massé : une parenté avec les pratiques de plusieurs économies occidentales ; la réunion de toutes les parties en vue de décisions communes ; la création d'une communauté d’intérêts dépassant les clivages habituels ; des contributions à la vérité des prix. C’est ce dernier point, qui a le moins laissé de traces dans la mémoire collective, que nous allons tenter de mettre en valeur ici, en rappelant les travaux qui, dérivés des théories dites néo-classiques de l’équilibre et de l’optimum, ont contribué, au Plan et dans sa sphère d’influence, à discipliner la croissance de l’économie française. Après un rappel de ce que pouvaient être les théories de la planification en ces temps, l'article examine les questions de la croissance optimale et du taux d’actualisation qui lui est associé, celle des politiques contraaléatoires, puis celle de la prise en compte des déséquilibres macroéconomiques dans le calcul économique public. Le Plan a été un cadre adapté à la société française d’alors, lui permettant de prendre certaines décisions en surmontant ses divisions. Le talent, et, ainsi que le souligne Jacques Lesourne, les qualités personnelles de beaucoup y contribuèrent fortement.
Role of Inflammatory Markers as Prognostic Indicators in Treatment of Mucormycosis
Authors: RajS Pruthvi , Godse Ashwini , Menon P Architha , T M Deepika , C Ravishankar 
Published: April 2023

Introduction: Mucormycosis is opportunistic fungal infection characterized by extensive inflammation, necrosis and infarction of the involved tissues. It is associated with rise in levels of inflammatory markers [Erythrocyte sedimentation rate (ESR) , C-reactive protein (CRP)]. This study was done to know the role of ESR, CRP as prognostic indicators in the treatment of covid-19 associated mucormycosis (CAM).
Materials and Methods: : A retrospective descriptive study was conducted between May 2021 and December 2021 at a tertiary centre. 315 patients with post-covid ROCM (Rhino-orbito-cerebral mucormycosis) were included in study. ESR and CRP were sent for all patients at the time of admission. Postoperatively the same were repeated on post-op (POD) day 7, day 14, and day 30 during follow-up.
Results: 243 (77.14%) patients were male and 72 (22.86%) were female. 6 patients with stage IV ROCM had recurrence of the disease in the postoperative period. Mean ESR values in these patients at the time of admission, POD-7, 14, 30 were 98.17, 68.17, 44.00, 80.33 respectively. Mean CRP values in these patients at the time of admission, POD-7, 14, 30 were 58.50, 48.17, 26.33,37.83 respectively.
Conclusion: Serial measurements of inflammatory markers (ESR, CRP) levels helps in the diagnosis and prognostication of ROCM along with clinical evaluation and imaging.
O IMPACTO DA VIDA ONLINE SOBRE A PERCEPÇÃO DA AUTOIMAGEM
Authors: Tinoco Gabriela Cozin Aragão , Silva Milena Barrera , Mituiwa Beatriz Moura , Vasconcelos Rossana Cantanhede Farias de 
Published: April 2023

Fundamentos: A pandemia do COVID-19 ampliou o uso de tecnologias de interação social, conectando os indivíduos virtualmente. Essa mudança trouxe uma nova tendência de insatisfações com a aparência induzida pelas mídias sociais, motivando a busca excessiva por procedimentos estéticos. Objetivo: Avaliar o impacto gerado pelo uso de apps na pandemia sobre a autoimagem dos entrevistados por sexo biológico, idade e renda familiar. Métodos: Foi realizado um estudo transversal, com 350 participantes, de faixa etária 18 anos ou mais, residentes no estado de São Paulo - Brasil, por meio de divulgação online de um formulário eletrônico. Os dados obtidos foram tabulados e analisados por teste qui quadrado e de Cochran, sendo cruzadas as variáveis renda, idade e sexo biológico. Resultados: Do total, 69,71% alegam mudanças na maneira que se veem fisicamente durante a pandemia; 58,3% relatam que os aplicativos influenciam na sua autoimagem, visto que 70,6% das respostas são mulheres entre 18-29 anos; 73,9% das mulheres de todas as idades e rendas reconheceram a importância da pele para a autoimagem, sendo esse dado discrepante entre as faixas etárias dos homens. Conclusões: O uso dos aplicativos na pandemia impactou sobre a autoimagem dos participantes, levando-os a terem maior interesse em obter futuros tratamentos e procedimentos estéticos.
Metformin Inhibits Autophagy, Mitophagy and Antagonizes Doxorubicin-Induced Cardiomyocyte Death
Authors: Van Jennifer , Hahn Younghee , Silverstein Brett , Li Cairong , Cai Fei , Wei Jia , Katiki Lokesh , Mehta Puja , Livatova Katherine , DelPozzo Jaclyn , Kobayashi Tamayo , Huang Yuan , Kobayashi Satoru , Liang Qiangrong 
Published: April 2023

Article
Metformin Inhibits Autophagy, Mitophagy and Antagonizes Doxorubicin-Induced Cardiomyocyte Death

Jennifer Van 1, Younghee Hahn 1, Brett Silverstein 1, Cairong Li 2, Fei Cai 2, Jia Wei 3, Lokesh Katiki 1, Puja Mehta 1, Katherine Livatova 1, Jaclyn DelPozzo 1, Tamayo Kobayashi 1, Yuan Huang 1, Satoru Kobayashi 1, and Qiangrong Liang 1, *

1 Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, New York 10001, United States
2 Clinical Medical College, Hubei University of Science and Technology, Xianning 332306, China
3 Department of Cardiology, the Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710000 , China
* Correspondence: qliang03@nyit.edu

Received: 28 November 2022
Accepted: 12 January 2023
Published: 17 February 2023

Abstract: The antidiabetic drug metformin has been shown to reduce cardiac injury under various pathological conditions, including anticancer drug doxorubicin (DOX)-induced cardiotoxicity, which makes metformin a prime candidate for repurposing. However, the mechanisms that mediate the cardioprotective effects of metformin remain highly controversial. In this study, we tested a prevailing hypothesis that metformin activates autophagy/mitophagy to reduce DOX cardiotoxicity. FVB/N mice and H9C2 cardiac myoblasts were treated with metformin, respectively. Autophagy/mitophagy was determined by Western blot analysis of microtubule-associated protein light chain 3, form-II (LC3-II), a well-established marker of autophagic vesicles. Although metformin had minimal effects on basal LC3-II levels, it significantly inhibited the accumulation of LC3-II levels by the lysosomal protease inhibitors pepstatin A and E64d in both total cell lysates and mitochondrial fractions. Also, dual fluorescent autophagy/mitophagy reporters demonstrated that metformin slowed the degradation rate of autophagic cargos or mitochondrial fragments in the lysosomes. These surprising results suggest that metformin inhibits rather than stimulates autophagy/mitophagy, sharply contrasting the popular belief. In addition, metformin diminished DOX-induced autophagy/mitophagy as well as cardiomyocyte death. Together, these results suggest that the cardioprotective effects of metformin against DOX cardiotoxicity may be mediated by its ability to inhibit autophagy and mitophagy, although the underlying molecular mechanisms remain to be determined.