bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Proteomics of Resistant and Susceptible Strains of Frankliniella occidentalis to Abamectin
Authors: Gholami Zahra , Fatehi Foad , Mehraban Fatemeh Habibpour , Haynes Paul A. , Jahromi Khalil Talebi , Hosseininaveh Vahid , Mosallanejad Hadi , Ingvarsson Pär K. , Farrokhi Naser 
Published: January 2025

ABSTRACTWestern flower thrips, Frankliniella occidentalis (Thysanoptera: Thripidae) is an invasive agricultural pest with developed resistance to abamectin in some strains due to frequent treatment with the pesticide. In this study, we examined differentially expressed proteins (DEPs) between abamectin‐resistant (AbaR; under abamectin selective pressure) and susceptible strains (AbaS; without abamectin selective pressure) of F. occidentalis. Proteins were isolated from second instar larvae of both strains and separated via two‐dimensional polyacrylamide gel electrophoresis. Nano‐flow liquid chromatography–tandem mass spectrometry identified selected protein spot features. From 70 DEPs, 43 spot features were identified: A total of 23 showed an increase in abundance, and 20 were down‐regulated in response to abamectin pressure. The enzymatic and structural proteins were classified into the functional groups of macromolecular metabolisms, signaling and cellular processes, immune system, genetic information processing, and exoskeleton‐related proteins. The up‐regulation of exoskeleton‐related proteins may contribute to forming a thicker cuticle, potentially hindering abamectin penetration, which is an interesting finding that needs further investigation. Two novel proteins, triacylglycerol lipase and cuticle protein CPF 2, were only expressed in AbaR. This work provides insights into abamectin resistance mechanisms in F. occidentalis, which will provide important information for developing insecticide resistance management approaches for this pest.
Estimation of Fuzzy Regression Parameters With ANFIS and Bayesian Methods
Authors: Pakdel M. , Razzaghnia T. , Fathi K. , Mostafaee A. 
Published: January 2025

ABSTRACTIn fuzzy regression, estimation of centers and spreads of triangular fuzzy numbers are both performed using the same methods, such as linear programming (LP), quadratic programming (QP), fuzzy weighted linear programming (FWLP), and adaptive neuro‐fuzzy inference system (ANFIS). In this article, ANFIS and Bayesian methods have been adopted to estimate centers and spreads of a triangular fuzzy numbers are applied, respectively, for estimation of centers and spreads of the triangular fuzzy data. To illustrate the efficiency of the proposed approach, three numerical examples have been used to verify the superiority of proposed method to other existing ones.
Entropy Analysis of Carreau Nanofluid Flow in the Presence of Joule Heating and Viscous Dissipation Past Unsteady Stretching Cylinder
Authors: Haile Gorfie Eshetu , Bayou Zegeye Gizachew , Awgichew Zergaw Gurju 
Published: January 2025

ABSTRACTThe study aims to investigate the irreversibilities of a Carreau nanofluid flow over, unsteady stretching cylindrical sheet exposed to radiation, non‐Darcy porous medium, viscous dissipation, joule heating, etc. It provides how energy produced in the nanofluid flow is used efficiently by minimizing the irreversibilities. The governing partial differential equations are transformed into first‐order initial value problems by similarity transformation and linearization. The shooting technique and an open‐source Python programming package are used to solve the initial value problems using the Runge–Kutta sixth‐order, and the numerical approach is validated using published articles. Basic flow profiles and, most importantly, entropy generation are examined using graphs in relation to relevant parameters. Skin friction and the behavior of heat and mass fluxes in response to various parameters are also examined. The results of the study demonstrated that the entropy creation is initiated by an increase in the magnetic and curvature parameters, as well as the Eckert, Brinkman, and porosity parameters. However, when the Forchheimer number increases, entropy generation decreases. An increase in the Eckert number, Prandtl number, and radiation parameter motivates the irreversibility due to heat transfer, whereas as the Weissenberg number rises, the irreversibility of heat transfer falls around the wall. According to the numerical values in the table, growth in Weissenberg number, thermal Biot number, Forchheimer number, curvature parameter, and radiation parameter initiate the magnitude of the rate of heat and mass transfers. In contrast, the rates fell as the Eckert and Prandtl values rose. Analysis of energy conversions and system efficiency can be done using this study, particularly in heat engines, refrigeration systems, and other thermodynamic processes.
Horizon Scanning Methods for Identification of New and Repurposed Medicines for Stakeholders in the United Kingdom
Authors: Khan Sarah , Fairbairn Ross , Potter Rhiannon , Hussain Amy , Inskip Alex , Norman Gill 
Published: January 2025

ABSTRACTHorizon scanning (HS) is a method for the identification of emerging change through systematic analysis of trusted sources using a defined scope and prespecified methods. In health research, it can provide early awareness of potential developments ahead of market access. Within the medicines space, HS is supported by international requirements for clinical trial registration, conduct and reporting, and by transparent regulatory processes. Potential changes can be identified at different stages of development, emerging, transitional, and imminent to launch. This paper delineates a comprehensive methodological approach for medicines HS within the transitional horizon from a national HS center, the National Institute for Health and Care Research Innovation Observatory (IO) in the United Kingdom. The UK single‐payer healthcare system supports access to medicines approved by the National Institute for Health and Care Excellence (NICE); the assessment process for this requires an early awareness program ahead of regulatory approval. We report an expansive step‐by‐step HS process at the IO that has been tailored to meet stakeholder requirements. Manual and automated methods are used in tandem to extract and sift data from clinical trial registries, industry databases and medical databases. Intensive industry engagement and news media sources are used to supplement data collection. Data are sifted and triangulated to populate an internal database. Records are monitored to allow tracking of technologies through the pipeline and to trigger our notification processes. This HS program is a potential model for other agencies wishing to establish such an early awareness program internationally.
Adherence to Oral Nutritional Supplements: A Review of Trends in Intervention Characteristics and Terminology Use Since the Year 2000
Authors: Skinnars Josefsson Malin , Einarsson Sandra , Seppälä Linn , Payne Liz , Söderström Lisa , Liljeberg Evelina 
Published: January 2025

ABSTRACTResearch on disease‐related malnutrition and adherence to oral nutritional supplements (ONS) has increased in recent years. To guide future studies, it is important to identify trends in terminology use and intervention characteristics. This review aimed to map characteristics of research investigating adherence to ONS in patients with disease‐related malnutrition and explore changes over time. This review is a secondary analysis of quantitative studies from a systematic mixed‐studies review. Online databases, including PubMed, Cinahl, Cochrane Central Register of Controlled Trials, and APA PsycInfo, were searched to identify studies published from 2000 to March 2022. A quantitative content analysis of extracted data was performed, and the Mixed Methods Appraisal Tool (MMAT) was used to assess methodological risk of bias. This review includes 137 articles, over half of which are randomized controlled trials (52%). The term “oral nutritional supplements” was used in 40% of the studies. Adherence to ONS was mainly described by the term “compliance” (69%). It was most common to offer ready‐made milk‐based ONS (56%) and ONS as a sole intervention (51%). The prescribed dose of ONS was fixed in 64% of studies and individualized in 22% of studies. There was variation in the methods used to assess adherence to ONS, and adherence was not reported in nearly a fifth of studies. There was an increase in methodological quality over time (p = 0.024). To ensure better understanding and increase the rigor and reproducibility of ONS intervention research, it is crucial to standardize the terminology used and to describe the interventions clearly.
Comparative Investigation of Novel Thermo‐Hydraulic Flow Characteristics and Augmentation of Heat Efficiency in 3D Pipes Based on Parametrical Corrugated Shape Configurations
Authors: Al‐Obaidi Ahmed Ramadhan 
Published: January 2025

ABSTRACTThis study investigates the effects of various corrugation shapes on heat performance and pressure drop characteristics in 3D pipe surfaces. Evaluating corrugation pipes' thermo‐hydrodynamic performance with respect to different corrugation configurations and Re is the main goal. The smooth flow is broken up in the double‐dimpled corrugated shape, causing tiny swirl zones to form and creating turbulence that increases heat exchanger performance and keeps particles from falling out of suspension. A heat exchanger is made possible by the corrugation's distinctive design, which improves heat transfer. Corrugated heat exchangers have the ability to alter the dimensions of smooth ones based on the application, whenever companies want a compact size for operation. Numerical simulations at Re ranging from 4000 to 12,000 are carried out under the assumption of a steady and consistent heat flux of 10,000 W/m2. Utilizing various models, the computational fluid dynamics solver is utilized to examine the effective characteristics of corrugation. The outcomes of temperature distributions, pressure drop, heat transfer coefficient, Nu, and f factors under various circumstances are discussed. For the conventional pipe, it was shown that different corrugation forms had a 22%–30% higher heat transfer coefficient. Because of the intricate corrugations, which enhance heat transfer and pressure drop, a greater Nu is achieved. Because corrugated geometries have a performance assessment criterion PEF greater than unity, they can outperform smooth pipes.
A case report of extra‐abdominal desmoid tumor after kidney transplantation
Authors: Matsuda Tsuyoshi , Yamada Shota , Tsuchiyama Ayaka , Kurata Hiroki , Mukae Yuta , Okano Shinji , Mochizuki Yasushi , Imamura Ryoichi 
Published: January 2025

IntroductionDesmoid tumors are rare, locally invasive, non‐metastasizing intermediate grade neoplasms. According to the organ procurement and transplantation network report, approximately one million solid organ transplants have been performed globally, from which only three desmoid tumors have been reported.Case presentationWe present the case of a 61‐year‐old male who developed an asymptomatic abdominal mass 3 years after kidney transplantation. Computed tomography revealed a 50‐mm mass attached to the Hem‐o‐lok clip beneath the right rectus abdominis muscle. A needle biopsy revealed β‐catenin positivity, which raised suspicion for a desmoid tumor. Due to progressive tumor enlargement, surgical excision was performed. The patient was discharged on postoperative day 5 without any surgical complications.ConclusionThis is the first documented case of an extra‐abdominal desmoid tumor after kidney transplantation. Although no recurrence has been observed over a 5‐year follow‐up period, careful long‐term monitoring is required because of the high recurrence rate of desmoid tumors.
The prognostic and therapeutic significance of polyunsaturated fatty acid‐derived oxylipins in ST‐segment elevation myocardial infarction
Authors: Du Zhiyong , Lu Yingyuan , Ma Ying , Yang Yunxiao , Luo Wei , Liu Sheng , Zhang Ming , Wang Yong , Li Lei , Li Chun , Wang Wei , Gao Hai 
Published: January 2025

AbstractPolyunsaturated fatty acid‐derived oxylipins regulate systemic inflammation and exert cardiovascular effects, yet their role in ST‐segment elevation myocardial infarction (STEMI) remains unclear. Herein, we used targeted metabolomics and machine learning algorithms to develop an oxylipin‐based risk model to accurately predict recurrent major adverse cardiovascular events (MACE) after STEMI in two independent prospective cohorts with 2 years of follow‐up. The in vivo effects of significant oxylipin predictors were explored via a murine myocardial ischemia‒reperfusion model and functional metabolomics. Among the 130 plasma oxylipins detected in discovery cohort (n = 645), patients with and without recurrent MACE exhibited significant differences in a variety of oxylipin subclasses. We constructed an oxylipin‐based prediction model that showed powerful performance in predicting recurrent MACE in the discovery cohort (predictive accuracy: 91.5%). The predictive value of the oxylipin marker panel was confirmed in an independent external validation cohort (predictive accuracy: 89.9%; n = 401). Furthermore, we found that the anti‐inflammatory/pro‐resolving oxylipin (ARO) predictor panel showed better prognostic performance than the pro‐inflammatory oxylipin predictor panel in both cohorts. Compared with the treatment of pro‐inflammatory oxylipin predictor panel, combined treatment of six ARO predictors, including 14,15 epoxy‐eicosatrienoic acid, 14(15)‐epoxy‐eicosatetraenoic acid, 12,13‐epoxy‐octadecenoic acid, lipoxin A4, resolving D1, and 6 keto‐prostaglandin F1 showed significant cardiac activities and synergistic metabolic actions in myocardial infarction‒reperfusion model mice. We also mechanistically identified an important role of ARO predictors in restraining ceramide/lysophosphatidylcholine synthesis and inhibiting inflammatory responses. Overall, the present study depicted the landscape of oxylipin profiles in the largest panel of STEMI patients worldwide. Our results also highlight the great potential of bioactive oxylipins in prognostic prediction and therapeutics after STEMI.
Place Matters: Understanding Geographic Influences on Youth Not in Education, Employment, or Training—A Scoping Review
Authors: Lindblad Victoria , Lund Rolf L. , Gaardsted Pernille Skou , Møller Hansen Line Elise , Lauritzen Fie Falk , Melgaard Dorte 
Published: January 2025

ABSTRACTIntroductionYouth aged 15–29 who are not engaged in education, employment, or training (NEET) represent a critical concern within the European Union (EU).AimThis review aims to ascertain whether existing studies address the impact of living in either rural or urban settings, or in specific types of neighborhoods, on the likelihood of young European individuals falling into NEET status.MethodsOn February 21, 2023, and subsequently updated on January 15, 2024, a thorough literature search was carried out across four major databases to compile relevant studies.ResultsFrom an initial pool of 33,314 articles, 11 studies were deemed relevant for this review involving over 786,399 participants. The analysis revealed that residing in disadvantaged neighborhoods, characterized by significant crime rates and unemployment levels surpassing national averages, correlates strongly with an increased incidence of NEET status among youth. Notably, impoverished areas with a high presence of visible minorities were associated with higher rates of school dropout or unemployment. Furthermore, the conditions of the local labor market were found to notably affect dropout rates from secondary schools, especially in urban centers. Whereas rural areas exhibited elevated unemployment rates among the youth.ConclusionsThis review underscores the need for targeted policies that address geographical disparities in NEET status by tailoring interventions to urban, rural, and neighborhood‐specific contexts. Policymakers should focus on localized support programs and integrate geographical factors into strategic planning to ensure equitable opportunities for all youth.
Patellofemoral arthroplasty provides similar long‐term survival rate and complications with better clinical outcomes compared to facetectomy for the treatment of isolated patellofemoral osteoarthritis
Authors: Martinez‐Lozano J. , Martorell‐de Fortuny L. , Martin‐Domínguez L. A. , Torres‐Claramunt R. , Sánchez‐Soler J. , Perelli S. , Hinarejos P. , Monllau J. C. 
Published: January 2025

AbstractPurposeThis study aimed to analyse the clinical outcomes and survival of patellofemoral arthroplasty (PFA) in treating isolated patellofemoral osteoarthritis (IPFOA) at our centre. The secondary objective was to compare these results with a historical cohort treated with partial lateral facetectomy plus Insall realignment (PLFIR). We hypothesised that clinical outcomes and survival with PFA are superior to PLFIR and comparable to the literature.MethodsA retrospective analysis of 120 patients with IPFOA was conducted. The PFA series included 33 patients treated between 2012 and 2019 with a minimum follow‐up of 5 years (range 1.2–12.1 years). The PLFIR historical cohort treated between 1995 and 2002 (range 4.1–15.7 years) consisted of 87 patients. Preoperative and post‐operative clinical outcomes were assessed using the Knee Society Score (KSS) and Kujala score, and survivorship was evaluated via Kaplan–Meier analysis. Cox regression analysis was used to identify factors influencing surgical failure.ResultsThe PFA group demonstrated a 75.8% survival rate at 10 years, with a 24.2% failure rate requiring conversion to total knee arthroplasty (TKA). In the PLFIR group, the 10‐year survival rate was 79.3%, although 26.4% required TKA. Both groups exhibited significant improvements in KSS and Kujala score, with PFA showing superior Kujala score improvement (p = 0.012). No statistically significant difference in survival between the two groups was observed at 10 years (p = 0.056), but PFA showed better long‐term clinical outcomes.ConclusionsPFA demonstrated comparable survival rates to PLFIR in the treatment of IPFOA. Despite a higher initial failure rate, PFA showed a potential for greater improvement in the long term, particularly in terms of anterior knee pain.Level of EvidenceLevel IV, retrospective case series analysis compared with a historical cohort.
Associations of Central Arterial Stiffness With Brain White Matter Integrity and Gray Matter Volume in MRI Across the Adult Lifespan
Authors: Won Junyeon , Tomoto Tsubasa , Shan Kevin , Tarumi Takashi , Zhang Rong 
Published: January 2025

BackgroundCentral arterial stiffening is associated with brain white matter (WM) damage and gray matter (GM) volume loss in older adults, but little is known about this association from an adult lifespan perspective.PurposeTo investigate the associations of central arterial stiffness with WM microstructural organization, WM lesion load, cortical thickness, and GM volume in healthy adults across the lifespan.Study TypeThis is a cross‐sectional study.SubjectsA total of 173 healthy adults (22–81 years) were included in this study.Field Strength/Sequence3‐T, T1‐weighted magnetization prepared rapid gradient echo (MPRAGE), single‐shot echo‐planar imaging diffusion‐weighted, and T2‐weighted fluid‐attenuated inversion recovery (FLAIR) sequences.AssessmentThe participants underwent measurements of central arterial stiffness using carotid‐femoral pulse wave velocity (cfPWV), diffusion tensor imaging (DTI) to measure whole‐brain WM microstructural organization with free water (FW) and FW‐corrected fractional anisotropy (FACOR), FLAIR to measure whole‐brain WM hyperintensities (WMH), and MPRAGE to measure whole‐brain cortical thickness and GM volume. The associations of age and cfPWV with MRI measures were assessed.Statistical TestsLinear regression models to examine the associations of brain WM and GM measures with age, cfPWV, and age × cfPWV interaction after adjusting for sex, education, and intracranial volume (ICV) (voxel‐wise and cluster threshold P < 0.05). To understand the direction of the interaction result, the sample was stratified into lower and higher cfPWV groups using a median split of cfPWV.ResultsAge × cfPWV interactions were observed in WM FW, WMH volume, cortical thickness, and GM volume (P < 0.01) such that the positive regression slopes between age, FW, and WMH volume were higher, while the negative regression slopes between age, cortical thickness, and GM volume were lower in those who had higher cfPWV relative to those who had lower cfPWV.Data ConclusionCentral arterial stiffening may accelerate the age‐related deteriorations in GM and WM structure across the adult lifespan.Plain Language SummaryCentral arterial stiffening is associated with brain white matter (WM) damage and gray matter (GM) volume loss in older adults. We extended this investigation into an adult lifespan perspective by examining the associations of central arterial stiffening with brain structure in adults across age. A total of 172 healthy adults (22–81 years) underwent central arterial stiffening measure using applanation tonometry and brain measurement using MRI. We observed that higher central arterial stiffening may accelerate the age‐related deterioration in brain WM and GM structure. These results suggest the importance of maintaining vascular health to slow age‐related brain structural changes from an adult lifespan perspective.Level of Evidence4Technical EfficacyStage 5
Disparities in cardiac arrest mortality among patients with chronic kidney disease: A US‐based epidemiological analysis
Authors: Shahid Mahek , Pham Hoang Nhat , Ibrahim Ramzi , Sainbayar Enkhtsogt , Abdelnabi Mahmoud , Pathangey Girish , Singh Amitoj 
Published: January 2025

AbstractBackgroundChronic kidney disease (CKD) increases cardiac arrest (CA) risk because of renal and cardiovascular interactions.MethodsUsing Centers for Disease Control and Prevention (CDC) data from 1999 to 2020, we analyzed CKD‐related CA mortality and the impact of social vulnerability index (SVI).ResultsWe identified 336 494 CKD‐related CA deaths, with stable age‐adjusted mortality rates over time. Disparities were observed across gender, racial/ethnic, and geographic subpopulations, with higher mortality among males, Hispanic and non‐Hispanic Black populations, and those in urban and Western regions. Higher SVI correlated with increased mortality.ConclusionsCKD‐related CA mortality rates are stable, with disparities across demographics; higher SVI correlates with increased mortality, highlighting needed interventions.
Artificial Intelligence and the Internal Processes of Creativity
Authors: Aru Jaan 
Published: January 2025

ABSTRACTArtificial intelligence (AI) systems capable of generating creative outputs are reshaping our understanding of creativity. This shift presents an opportunity for creativity researchers to reevaluate the key components of the creative process. In particular, the advanced capabilities of AI underscore the importance of studying the internal processes of creativity. This paper explores the neurobiological machinery that underlies these internal processes and describes the experiential component of creativity. It is concluded that although the products of artificial and human creativity can be similar, the internal processes are different. The paper also discusses how AI may negatively affect the internal processes of human creativity, such as the development of skills, the authenticity of creativity, and the diversity of ideas.