bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-frequency terahertz waves disrupt Alzheimer’s β-amyloid fibril formation
Authors: Peng Wenyu , Zhu Zhi , Lou Jing , Chen Kun , Wu Yuanming , Chang Chao 
Published: August 2023

AbstractThe accumulation and deposition of amyloid can cause a variety of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease. The degradation or clearance of this accumulation is currently the most widely accepted therapeutic strategy for intervention in these pathologies. Our study on amyloid-β (Aβ) oligomers in vitro revealed that high-frequency terahertz (THz) waves at a specific frequency of 34.88 THz could serve as a physical, efficient, non-thermal denaturation technique to delay the fibrotic process by 80%, as monitored by a thioflavine T (ThT) binding assay and Fourier transform infrared (FTIR) spectroscopy. Additionally, THz waves of this frequency have been shown to have no side effects on normal cells, as confirmed by cell viability and mitochondrial membrane potential assays. Furthermore, molecular dynamic (MD) simulations revealed that the THz waves could resonate with Aβ fibrils, disrupting the dense conformation by breaking the β-sheet structure and promoting the formation of abundant coil and bend structures. This study uses the amyloid of Aβ as an example, and the results will further guide interventions for the accumulation of other amyloids, which may provide new ideas for the remission of related diseases.
A surgical case of abscess of the sternal region due to synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome
Authors: Tada Makoto , Uehara Hirofumi , Ohyu Takeshi , Watanabe Atsushi 
Published: August 2023

Abstract
Background
Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare chronic inflammatory disorder characterized by cystic skin disease, aseptic osteomyelitis, and hyperostosis. It is rarely associated with subcutaneous abscesses in the anterior chest wall. Herein, we describe a case of a sternal abscess due to SAPHO syndrome that was successfully treated with debridement.

Case presentation
A 62-year-old female patient presented with a chief complaint of a mass in the right anterior chest region. Computed tomography showed the presence of an abscess around the sternum. Magnetic resonance imaging revealed inflammation of the spine. The patient also had a history of palmoplantar pustulosis, raising the suspicion of SAPHO syndrome; however, sternoclavicular joint infection could not be excluded. Abscess drainage and wall debridement were performed. However, reaccumulation of the abscess occurred early after surgery. Although culture tests of the abscess were negative, histopathological examination of the abscess wall revealed a tuberculoid granuloma. Owing to unsuccessful open wound management, debridement of the anterior thoracic skin and abscess wall and partial sternal resection were performed 2 months after the initial surgery. Negative-pressure wound therapy (NPWT) was applied for 4 weeks after surgery, followed by immunosuppressant administration. The patient underwent split-thickness skin grafting on postoperative day 65 and had no abscess recurrence at 18 months post-surgery.

Conclusions
Abscesses in the sternal region caused by SAPHO syndrome can be difficult to differentiate from infectious arthritis. Therefore, drainage and debridement should be considered if infection cannot be excluded.
3D imaging of left atrial dissection: a case report
Authors: Okano Ryoi , Kawashima Dai , Koshiba Yusuke , Ai Kimiaki , Ando Takuya , Suzuki Satoshi , Maeba Satoru 
Published: August 2023

Abstract
Background
Left atrial dissection (LAD) is an uncommon but potentially devastating complication of cardiac surgery. Though surgical and conservative treatment strategies have been reported, the choice depends on each clinical situation. Especially in sensitive cases, the decision could be difficult, where the detailed assessment of the multiple imaging modalities is mandatory.

Case presentation
Open surgical total arch replacement (TAR) was performed on a male patient aged 79 years old, who had severe chronic obstructive pulmonary disease (COPD) and a history of aortofemoral bypass for abdominal aortic aneurysm and arteriosclerosis obliterans (ASO). During the weaning off the cardiopulmonary bypass (CPB), LAD was detected on intraoperative transesophageal echocardiography (TEE). It was 18 × 26 mm and full of hematoma with the TEE. Due to the patient’s frailty and not to elongate the CPB duration, we selected a conservative strategy. The patient was extubated on postoperative day (POD) 1 and transferred from ICU to the ward on POD 3. On POD 7, ECG-gated 3D-CT was performed, on which LAD occupied 26% of the left atrial volume. It also revealed the opening of the pulmonary veins and the proximity of the LAD and the coronary sinus (CS). The cause of the LAD was considered to be the CS perforation with a retrograde cardioplegic cannula. A follow-up 3D-TEE was performed on POD 15, where the hematoma inside the LAD was absorbed. He was discharged home at POD 23. With transthoracic echocardiography, LAD itself disappeared after 3 months.

Conclusion
3D imaging, such as 3D-TEE and 3D-CT, is valuable in the assessment of the volume and quality of LAD. Furthermore, it clarifies the exact position and configuration of LAD, which help in assessing the etiology, predicting the hemodynamic disturbance, and determining the treatment strategy. They are potent tools, especially in complex cases.
Effective application of indocyanine green for visualization of the thoracic duct during video-assisted thoracoscopic surgery for chylothorax: a case report
Authors: Hashimoto Teppei , Osaki Toshihiro , Oka Soichi , Ueda Hiroyuki 
Published: August 2023

Abstract
Background
Chylothorax is an accumulation of typically milky-appearing lymphatic fluid within the pleural cavity. High-output chylothorax may lead to a severe risk of death if not treated promptly. Several studies have reported the effectiveness of indocyanine green (ICG) for chylothorax following lung cancer surgery, esophagectomy, and congenital and recurrent idiopathic chylothorax. Here, we report a case of a successful treatment of idiopathic chylothorax in an adult by identifying and ligating the thoracic duct (TD) using fluorescent thoracoscopy with inguinal lymph node injection of ICG.

Case presentation
A 79-year-old man with nephrotic syndrome presented with a massive right pleural effusion. Based on the pleural effusion examination, the patient was diagnosed with idiopathic chylothorax. He underwent 26 days of conservative treatments, including intercostal chest tube drainage, subcutaneous injection of a somatostatin analog (octreotide), and diet control (low-fat diet, fasting). However, the conservative treatments failed. Therefore, thoracoscopic TD ligation using a combination of ICG and near-infrared (NIR) light was performed. Ultrasound-guided inguinal lymph node injection of ICG was performed before thoracoscopy. Although standard-mode thoracoscopy could not identify leakage points, when observed under NIR light, the TD could be detected using fluorescence contrast. The TD was clipped to the deepest level on the thoracic side. Furthermore, a fluorescence hotspot of ICG on the cranial side of the clipped TD, likely a leakage point, was confirmed, and the lesion was clipped. ICG fluorescence did not disappear during surgery. The thoracic tube was removed on postoperative day 7. To date, chylothorax has not recurred.

Conclusions
We report the effectiveness of intraoperative NIR fluorescence with ICG in identifying the TD’s running. This technique can lead us to identify and ligate the TD with assurance and accurately treat chylothorax.
Treatment Persistence and Medication Switch Associated With Subsequent Fractures After Osteoporotic Fractures
Authors: Lin Sung-Yen , Chen Wei-Ju , Ku Chieh-Ko , Chen Yi-Ming , Chen Chung-Hwan , Chien Li-Nien 
Published: August 2023

Abstract

Context
Despite prevalent anti-osteoporosis medication (AOM) switching in real-world osteoporosis management, few studies have evaluated the impact of persistent AOM treatment, allowing for AOM switching, on the risk of subsequent fracture.

Objective
We examined the association between persistence in AOM and subsequent fractures, allowing for medication switching among patients with osteoporotic fractures.

Methods
This retrospective cohort study used Taiwan National Health Insurance claims data to select patients who initiated AOM between 2013 and 2016. Treatment persistence was defined as use of any AOM on a given day of interest with a 45-day grace period. Medication switch was allowed for persistence if remaining on treatment. AOMs with long-lasting inhibition of bone resorption (zoledronate and denosumab) were categorized as high-potency; others as low-potency. Multivariate Cox models were used to evaluate risk of subsequent fractures ≥3 months after initiating AOM.

Results
A total of 119 473 patients were included (mean [SD] follow-up 46.4 [15.6] months), and 26.8% switched from the index AOM. Within 1 year, 52% remained persistent with AOM. Compared to patients with persistent AOM, those not persistent had higher risk of subsequent hip (adjusted hazard ratio [aHR] = 1.31; 95% CI, 1.21-1.42), vertebral (aHR = 1.17; 95% CI, 1.13-1.22), and radius fractures (aHR = 1.16; 95% CI, 1.08-1.25). Patients with persistent AOM who switched from high- to low-potency AOM had higher risk of subsequent vertebral fractures than those with persistent AOM and no potency switch (aHR = 1.28; 95% CI, 1.02-1.60).

Conclusion
Patients with non-persistent AOM had higher risk of subsequent fractures than persistent users when allowing AOM switch. Switching AOM potency may influence the risk of subsequent vertebral fractures and warrants further investigation.
Single-cell profiling of the developing embryonic heart in Drosophila
Authors: Huang Xiaohu , Fu Yulong , Lee Hangnoh , Zhao Yunpo , Yang Wendy , van de Leemput Joyce , Han Zhe 
Published: August 2023

ABSTRACT
Drosophila is an important model for studying heart development and disease. Yet, single-cell transcriptomic data of its developing heart have not been performed. Here, we report single-cell profiling of the entire fly heart using ∼3000 Hand-GFP embryos collected at five consecutive developmental stages, ranging from bilateral migrating rows of cardiac progenitors to a fused heart tube. The data revealed six distinct cardiac cell types in the embryonic fly heart: cardioblasts, both Svp+ and Tin+ subtypes; and five types of pericardial cell (PC) that can be distinguished by four key transcription factors (Eve, Odd, Ct and Tin) and include the newly described end of the line PC. Notably, the embryonic fly heart combines transcriptional signatures of the mammalian first and second heart fields. Using unique markers for each heart cell type, we defined their number and location during heart development to build a comprehensive 3D cell map. These data provide a resource to track the expression of any gene in the developing fly heart, which can serve as a reference to study genetic perturbations and cardiac diseases.
Survival of Patients with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer Receiving Curative-Intent Local Treatment of Metastases in a Nationwide Cohort
Authors: Zwart Koen , van der Baan Frederieke H. , Punt Cornelis J. A. , Wensink G. Emerens , Bolhuis Karen , Laclé Miangela M. , van Grevenstein Wilhelmina M. U. , Hagendoorn Jeroen , de Hingh Ignace H. , Koopman Miriam , Vink Geraldine , Roodhart Jeanine 
Published: August 2023

Abstract
Background
It is unclear whether curative-intent local therapy of metastases is of similar benefit for the biological distinct subgroup of patients with deficient mismatch repair (dMMR) metastatic colorectal cancer (mCRC) compared with proficient mismatch repair (pMMR) mCRC.

Patients and Methods
In this nationwide study, recurrence-free (RFS) and overall survival (OS) were analyzed in patients with dMMR versus pMMR mCRC who underwent curative-intent local treatment of metastases between 2015 and 2018. Subgroup analyses were performed for resection of colorectal liver metastases (CRLM) and cytoreductive surgery ± hyperthermic intraperitoneal chemotherapy (CRS ± HIPEC). Multivariable regression was conducted.

Results
Median RFS was 11.1 months [95% confidence interval (CI) 8.5–41.1 months] for patients with dMMR tumors compared with 8.9 months (95% CI 8.1–9.8 months) for pMMR tumors. Two-year RFS was higher in patients with dMMR versus pMMR (43% vs. 21%). Results were similar within subgroups of local treatment (CRLM and CRS ± HIPEC). Characteristics differed significantly between patients with dMMR and pMMR mCRC; however, multivariable analysis continued to demonstrate dMMR as independent factor for improved RFS [hazard ratio (HR): 0.57, 95% CI 0.38–0.87]. Median OS was 33.3 months for dMMR mCRC compared with 43.5 months for pMMR mCRC, mainly due to poor survival of patients with dMMR in cases of recurrence in the preimmunotherapy era.

Conclusion
Patients with dMMR eligible for curative-intent local treatment of metastases showed a comparable to more favorable RFS compared with patients with pMMR, with a clinically relevant proportion of patients remaining free of recurrence. This supports local treatment as a valuable treatment option in patients with dMMR mCRC and can aid in shared decision-making regarding upfront local therapy versus immunotherapy.
Association between the risk perception of contracting COVID-19 and sociodemographic characteristics in a Peruvian population
Authors: Zeladita-Huaman Jhon Alex , Esteban-Espinoza David , Lozada-Urbano Michelle , Franco Chalco Eduardo , Costa Marcelo Fernandes , Castillo-Parra Henry 
Published: August 2023

Background: The perception of risk regarding coronavirus disease 2019 (COVID-19) has been widely researched due to its association with the adoption of preventive measures. In addition, since the onset of vaccination, it has been reported that the population perceives a lower risk of getting infected. However, few studies have analyzed the factors associated with risk perception in low- and middle-income countries. The aim of this study was to determine the association between the risk perception of contracting COVID-19 and sociodemographic characteristics in Peruvian population. Methods: An analytical and cross-sectional study was conducted in four cities in Peru from October to December, 2021. The sample consisted of 821 individuals aged 18 years and older. A virtual questionnaire was used to collect sociodemographic data and assess the risk perception of contracting coronavirus based on the Health Belief Model. The process of back-translation, expert judgment, and reliability analysis using split-half correlation was conducted. Student's t-tests, analysis of variance with post hoc Tukey's test, and Spearman's correlation were employed. Results: Of the participants, 53.71% were women and 73.3% had a higher education level, 45.55% are self-employed, and 40.44% did not have a family member infected with COVID-19. The risk perception of COVID-19 infection was associated with participants' family antecedent of COVID-19 (p < 0.05). Regarding the factors analyzed, perceived susceptibility to COVID-19 was associated with age (p=0.002), occupation (p<0.05), and a history of COVID-19 (p<0.05), while the perceived benefits of adopting preventive measures against this disease were associated with educational level (p < 0.001). Conclusions: The risk perception of contracting COVID-19 was higher among those who had multiple infected relatives. Furthermore, the perception of susceptibility and the perceived benefits of using preventive measures were associated with sociodemographic characteristics.
Pilot project on use of social simulation to improve multidisciplinary medical education on health-related social needs
Authors: Rehman Tehreem , Okubanjo Oyinkansola 
Published: August 2023

Background: Competence in system-based practice in medical education must include training on functioning as an interprofessional team member to address health-related social needs (HRSN). This pilot targets the existing gap on teaching residents how to leverage interprofessional expertise and larger context of HRSN in patient care.This pilot applied the principles of social simulation to teach residents how to work with interprofessional partners to effectively address patients’ HRSN. Methods: We developed simulation cases on HRSN commonly encountered in our Emergency Department. A 9-item instrument using a Likert 5-level scale assessed participants’ knowledge and skills on HRSN before and after the simulation implemented in 2021. Unmatched data largely from missing ID in responses were omitted. The Wilcoxon signed-rank test was used to assess for significant changes pre- and post-intervention. Results: Thirty-three of forty eligible Emergency Medicine (EM) residents (82.5%) participated in the study. Eighteen of thirty-three participants (response rate 54.5%) were included when matching data based on ID. We found significant differences in self-reported ability to identify patients’ HRSN (p=.0014), differentiate between the roles of interdisciplinary team members (p=.0007), and ability to identify hospital resources patients could be referred to (p=.0018). There was no difference in self-reported sense of empowerment in response to perceived ability in addressing a patient’s HRSN. Conclusions: Findings from this pilot suggest that social simulation can be an effective tool for teaching residents how to function in interprofessional teams and navigate the dynamic larger healthcare context of social determinants of health (SDOH) in addressing a patient’s HRSN. Competence in system-based practice in multidisciplinary medical education must include training on functioning as an interprofessional team member to address SDOH. This pilot targets the existing gap in teaching residents how to leverage interprofessional expertise and the larger context of SDOH in patient care.
Chomsky’s Theory of Mind: Concepts and Contents
Authors: Tantray Mudasir Ahmad 
Published: August 2023

Nowadays, it is very debatable among philosophers, psychologists, linguists and artificial intelligence scientists that what mind actually is, where it exists and how it works? Chomsky, the great philosopher and the main exponent of cognitive revolution tries to sketch the description of mind, its nature, mental processes, its structure as well as its relation with its other cognitive modules. It also examines innate and acquired knowledge of mind. In this paper, I shall argue about the capacities of the mind, why Chomsky called mind capacity as different from its ability and other faculties. This paper also describes the theories that are connected with the field of mind i.e, mind and language, linguistic mentalism, Modular mind, Cartesian mind, mind-body problem, Philosophical grammar, and thought processes like reasoning and perceptions. Firstly, I shall argue about, does Chomsky consider mind different from brain, consciousness and thought? Secondly, does Chomsky consider mind as a separate concept or he regards it as the constituent of language only? And thirdly, how Chomsky responds to rationalists and empiricists?
Examining Asian Destination Quality Attributes And Recovery Strategies In Advent Of Covid-19: A Systematic Review
Authors: Mhango Lenard , Dias Cheryl Venan 
Published: August 2023

The advent of COVID-19 in Asia has piqued interest for research and publication from the discipline of tourism and destination management. In order to assess how the pandemic affected both DQAs and recovery efforts, this study employed a systematic review methodology. The review of a literature followed the PRISMA’s protocol. The first screening extracted 165 papers from Dimensions and Lens web sources, which were further filtered according to their date of publication, publication type, keywords, publisher, and title relevance. After the initial screening, from the preliminary articles which were retained for consideration, 60 met inclusion criteria. To identify the concurrency of topics, a consolidated spreadsheet was mapped using Vosviewer and Nvivo software. The mapping process identified three main topics, destination attributes, impacts, and recovery strategies. The study used descriptive Meta-ethnography approaches to further synthesize the data. It is observed that the majority of articles reviewed are published between 2021 and 2022 and the majority use quantitative and qualitative methods. China contributed the majority of the articles while Indonesia and India contributed a significant number. Meta-ethnography synthesis revealed seven concepts related to each of the three main dimensions. The findings raise anxiety to revisit destination management practices and policies post-pandemic. The study recommends that destination managers should spend quality time understanding which attributes are fragile and critical to change destination performance. quality management, practices and policies in times of pandemics
Review: proteins c-Myc and Myc-nick as potential targets for the melignant melanoma treatment
Authors: Maryniuk G. , Stepanov G. , Oleynik K. , Selyvanska I. , Tereshchenko L. , Dubna Y. 
Published: August 2023

Malignant melanoma is the most aggressive and life-threatening skin cancer with increasing incidences over the past decades. Despite accounting for only 4 % of all skin cancers, melanoma confers 80 % of skin cancer induced death. The underlying cause of melanoma progression and metastasis is poorly understood.
Myc is a very strong proto-oncogene and it is very upregulated in many types of cancers. c-Myc protein is a transcription factor that activates expression of many genes. It drives cell proliferation, plays a very important role in regulating cell growth, apoptosis and differentiation. High c-Myc expression is associated with tumor metastasis and poor prognosis in human melanoma.
Full-length c-Myc is converted into Myc-nick by calcium-dependent on cytosolic proteases that are members of the calpain family. In connection with the key role of the cytoplasmic protein Myc-nick in the autophagy activativation, increasing the resistance to chemotherapy and overall survival of tumor cells, it can be a target for treatment tumors under the conditions of c-Myc overexpression. That fact that the expression of Myc-nick increases the survival of cells after UV radiation can indicate the key role of the Myc-nick in tumorogenesis of melanoma cells.
Birds of a Feather: Do Hedge Fund Managers Flock Together?
Authors: Gerritzen Marc , Jackwerth Jens , Plazzi Alberto 
Published: August 2023

Mandatory filings for UK hedge funds suggest that managers having worked at the same prior employer invest more similarly in terms of distances of returns. If they overlapped in employment, increasing the chance of social ties, investments become even more similar. The joint effect accounts for up to two thirds of the difference in investing behavior. Results are robust to fund- and manager-level controls as well as to identification concerns. With controls, the same-employer effect is concentrated in the systematic component (beta), whereas the overlap effect is concentrated in the idiosyncratic components (alpha and residuals). Managerial ties make any two funds more similar in their stock holdings. Moreover, portfolios of connected funds outperform their peers in terms of alpha, return volatility, and Sharpe ratio. This paper was accepted by Victoria Ivashina, finance. Supplemental Material: The data file is available at https://doi.org/10.1287/mnsc.2023.4843 .