bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infection reporting in patients undergoing irreversible electroporation of locally advanced pancreatic cancer
Authors: Filson Anthony , Martin Robert C. G. 
Published: May 2023

AbstractBackgroundIntraoperative bile cultures (IOBCs) taken during pancreatic surgery are commonly performed and there has been limited evidence that a positive IOBC could aid in perioperative adverse event (AE) management. Therefore, this study aims to describe infection management in patients undergoing irreversible electroporation (IRE).MethodsAn Institutional Review Board (IRB)‐approved prospective database was utilized from 8/2016 to 6/2022, with 127 pancreatic adenocarcinoma patients included.ResultsA total of 28 patients that underwent IRE also had a simultaneous positive IOBC and the remaining 99 patients that underwent IRE had negative IOBC. A total of 11(39%) of the patients with a positive IOBC had AE's, and 38 (38%) of the patients with negative IOBC had AE's. Both groups had similar rates of AEs leading to new hospitalization and prolonged hospitalizations. Overall, there was no correlation between a positive IOBC and a patient developing an AE.ConclusionsThe findings of this study provide insights that improve the infectious management of patients undergoing IRE.
The local Borg–Marchenko uniqueness theorem of matrix‐valued Dirac‐type operators for coefficients locally smooth at the right endpoint
Authors: Wei Guangsheng , Zhang Zhongfang 
Published: May 2023

AbstractWe provide an expression of the Weyl–Titchmarsh matrix associated with a self‐adjoint matrix‐valued Dirac‐type operator defined on [0, b) for . As a concrete application of it, we establish asymptotics of the difference of two Weyl–Titchmarsh matrices corresponding to two Dirac‐type operators , with a.e. on [0, a], in with , when the are sufficiently smooth in a right neighborhood of the point a and their right derivatives at a coincide up to a certain order. In addition to this, we also provide new proofs of the local Borg–Marchenko theorem and asymptotic high‐energy expansion of Weyl–Titchmarsh matrices associated with Dirac‐type operators.
Simply connected Voisin manifolds of dimension four
Authors: Wang Linsheng 
Published: May 2023

AbstractVoisin constructed a series of examples of simply connected compact Kähler manifolds of even dimension, which do not have the rational homotopy type of a complex projective manifold starting from dimension six. In this note, we prove that Voisin's examples of dimension four also do not have the rational homotopy type of a complex projective manifold. Oguiso constructed simply connected compact Kähler manifolds starting from dimension four, which cannot deform to a complex projective manifold under a small deformation. We also prove that Oguiso's examples do not have the rational homotopy type of a complex projective manifold.
Photochromic Polyurethane Coatings with Cross‐Linked Structure and Self‐Healing Behavior Based on the FRET Effect
Authors: Liu Yayuan , Tian Fuyue , Hu Jing , Ning Nanying , Yu Bing , Tian Ming 
Published: May 2023

AbstractIntelligent fluorescent coatings have received widespread attention in the encryption technique field such as anti‐counterfeit, while the traditional fluorescent coatings are easy to be damaged by external force. In this study, the fluorescent and self‐healing anti‐counterfeit coatings are prepared after rational molecular design. Two polymers containing fluorescent groups, including polyurethane containing the anthracene (AN) side group and polyimide containing the naphthalenediimide (NDI) structure are synthesized to realize multiple color changes with fluorescence through simply blending. Due to the overlapping fluorescence spectra of the groups, enabling the fluorescence resonance energy transfer effect (FRET), the coating with different group ratios exhibits tunable fluorescence under the same excitation light, providing diverse patterns. Moreover, due to the reversible photo‐crosslinking and thermal de‐dimerization properties of anthracene, the recording, erasure, and rewriting of the surface pattern can be realized, and the fluorescent anti‐counterfeit coatings exhibit excellent self‐healing properties after cross‐linking due to the FRET effect, which solves the problem of poor healing and ensures the stability and integrity. The fluorescent coating with cross‐linked structure and self‐healing behavior based on the FRET effect greatly expands the functional applications of traditional polyurethane materials.
Novel heterozygous variants in the EP300 gene cause Rubinstein–Taybi syndrome 2: Reports from two Chinese children
Authors: Du Caiqi , Li Zhuoguang , Zou Biao , Li Xuesong , Chen Fan , Liang Yan , Luo Xiaoping , Shu Sainan 
Published: May 2023

AbstractBackgroundRubinstein–Taybi syndrome (RSTS) is a rare autosomal‐dominant genetic disease caused by variants of CREBBP (RSTS1) or EP300 (RSTS2) gene. RSTS2 is much less common, with less than 200 reported cases worldwide to date. More reports are still needed to increase the understanding of its clinical manifestations and genetic characteristics.MethodsThe clinical data of two children with RSTS2 were analyzed retrospectively, and their clinical manifestations, auxiliary examinations, and mutational spectrum were summarized. Liquid chromatography–tandem mass spectrometer (LC–MS/MS) technology was used to detect the levels of steroid hormones if possible.ResultsAfter analyzing the clinical and genetic characteristics of two boys with RSTS2 (0.7 and 10.4 years old, respectively) admitted in our hospital, we identified two novel heterozygous variants in the EP300 exon 22 (c.3750C > A, p. Cys1250*, pathogenic; c.1889A > G, p. Tyr630Cys, likely pathogenic), which could account for their phenotype. In addition to common clinical manifestations such as special facial features, microcephaly, growth retardation, intellectual disability, speech delay, congenital heart defect, recurrent respiratory infections, and immunodeficiency, we found one of them had a rare feature of adrenal insufficiency, and LC–MS/MS detection showed an overall decrease in steroid hormones.ConclusionIn our study, we identified two novel variants in the EP300 exon 22, and for the first time, we reported a case of RSTS2 associated with adrenal insufficiency, which will enrich the clinical and mutational spectrum of this syndrome.
Adoption and Utilization of Heat and Moisture Exchangers (HMEs) in the Tracheostomy Patient
Authors: Kearney Ann , Norris Kristi , Bertelsen Carol , Samad Idris , Cambridge Maribeth , Croft Glenn , Peavler Staci , Groen Christa , Doyle Philip C. , Damrose Edward J. 
Published: May 2023

AbstractObjectiveManagement of tracheostomized patients typically involves a conventional external humidification system (CEHS). CEHS are noisy, negatively impact patient mobility, and increases costs. Additionally, they prevent phonation and the ability to cough. Alternatively, heat and moisture exchange (HME) devices have been used in laryngectomized patients. We present an institutional quality improvement project exploring the use and efficacy of an HME device following tracheostomy.MethodsHealth care professionals and stakeholders from multiple disciplines were identified: otolaryngology, nursing, administration, case management, and speech‐language pathology. The focus was on an otolaryngology acute care nursing unit. Protocols for product acquisition, nursing education, care flowcharts, and discharge planning were established. Efficacy was assessed by tracking patient pulmonary status, nursing notes, and questionnaires.ResultsSeventy‐one tracheostomized patients were enrolled. Two patients (2.8%) were unable to tolerate the HME. There were no complications from mucous plugging or respiratory distress. Eighty‐nine percent of nursing staff surveyed preferred the use of an HME device over CEHS, particularly for ease of patient mobility. Additional favorable findings were patient satisfaction, cost savings, reduced noise, communication, and ease of discharge education and planning.DiscussionReplacing CEHS with HMEs provides distinct advantages, with a positive impact on patients, family members, and health care personnel. Resistance to changing from the traditional standard of care was alleviated with education, focused training, and positive outcomes.Implications for PracticeThese data indicate that an HME device is safe and offers advantages to both patients and nurses over traditional CEHS.
Unique Measurements of Intranasal Trigeminal Function: A Pilot Study
Authors: Durrant Frederick G. , Chen Tiffany , Poupore Nicolas S. , Nguyen Shaun A. , Chapurin Nikita , Schlosser Rodney J. 
Published: May 2023

AbstractObjectiveTo investigate novel methods of measuring intranasal trigeminal function and correlate to validated measures of trigeminal function.Study DesignProspective cohort study.SettingTertiary medical center.MethodsForty‐one subjects without nasal congestion were assessed. The trigeminal temperature function of the cool/warmth detection threshold and cold/heat pain threshold was measured with the Thermal Sensory Analyzer (TSA) device, as previously validated at buccal mucosa and infraorbital skin. Identical temperature sensory function was assessed at the anterior septum and inferior turbinate. Lateralization of trigeminal odorants eucalyptol, isothiocyanate, and acetic acid was conducted. Visual analog scales (VAS) of trigeminal function were collected.ResultsExtraoral cheek site and oral site thermal measures were moderately correlated, suggesting consistent assessment of trigeminal function. Nearly all intranasal thermal measures correlated between the septum and turbinate (significant correlations [ρ] ranged from .3 to .8). Oral and extraoral cheek sites had modest correlations to intranasal cold and heat pain (ρ = .4‐.5). The oral site had modest correlations of cold and heat detection to intranasal sites, with turbinate appearing to have the most correlations. Isothiocyanate lateralization was the most closely correlated to intranasal thermal scores for cold and heat pain. Turbinate thermal measures had weak correlations with trigeminal VAS scores (ρ = .3‐.4).ConclusionIntranasal trigeminal measures of thermal function correlate to validated extraoral and intraoral thermal measures. The turbinate appears to have stronger correlations to the septum than found in the mouth and face. TSA testing might provide a rapid, novel method of intranasal trigeminal function assessment.
Managing the risk of MOC
Authors: Chosnek Jack 
Published: May 2023

AbstractDuring the execution of a change using Management of Change (MOC), the risk to the facility is increased because things are in flux until the change is completed and documented and personnel trained. During this time P&IDs, SOPs, and other procedures are being developed or changed. Construction or tie‐ins in preparation, or as part of the change, are going on. Thus, during the change until it is complete, the potential for error, and therefore the risk, is increased. This potential for error emanates from the use of not‐yet implemented P&IDs, the use of unapproved or old procedures, and unintended connections and flows from or to piping that contains hazardous materials. Additional risk results from an incorrect workflow where the appropriate individuals were not included in the review or the necessary approvals are bypassed. Another possible risk is unknowingly impacting an existing safeguard by changing related equipment. Thus, the MOC process needs to be carefully managed, not only for an individual MOC but the aggregate of all the MOCs that are being worked on at the same time. The elements for minimizing the risk of a change are described, and a tool to monitor the MOC process, which includes automatic metrics, is illustrated.
Development of a sensitive and quantitative HPLC‐FLD method for the determination of obestatin in human plasma
Authors: Atila Karaca Sakine , Temel Tuncer , Yeniceli Uğur Duygu 
Published: May 2023

Obestatin is a gastrointestinal system peptide. The quantification of this peptide is conventionally performed using immunological techniques. In this study, a selective and sensitive HPLC method coupled with fluorescence detection for the quantitation of obestatin in human plasma was developed and validated. The separation was obtained on a C18 (4.6 × 100 mm, 3.5‐μm particles) column using a mobile phase composed of acetonitrile and water, both including 0.1% trifluoroacetic acid. The developed method was found to be linear in the concentration range of 20 to 1000 ng/mL, with a coefficient of determination of 0.9982. The precision results were less than 10%, and the accuracy results were between 92% and 107%. The detection and quantification limit values were obtained as 2.8 and 9.4 ng/mL, respectively. Analyte solutions were found stable for 24 h at room temperature, three freeze–thaw cycles, and 2 weeks at −20°C. The developed method was successfully used for the quantification of obestatin in human plasma samples. In conclusion, the developed method is sensitive and specific for measuring the plasma concentrations of obestatin.
Physiologically‐based pharmacokinetic modeling of quinidine to establish a CYP3A4, P‐gp, and CYP2D6 drug–drug–gene interaction network
Authors: Feick Denise , Rüdesheim Simeon , Marok Fatima Zahra , Selzer Dominik , Loer Helena Leonie Hanae , Teutonico Donato , Frechen Sebastian , van der Lee Maaike , Moes Dirk Jan A. R. , Swen Jesse J. , Schwab Matthias , Lehr Thorsten 
Published: May 2023

AbstractThe antiarrhythmic agent quinidine is a potent inhibitor of cytochrome P450 (CYP) 2D6 and P‐glycoprotein (P‐gp) and is therefore recommended for use in clinical drug–drug interaction (DDI) studies. However, as quinidine is also a substrate of CYP3A4 and P‐gp, it is susceptible to DDIs involving these proteins. Physiologically‐based pharmacokinetic (PBPK) modeling can help to mechanistically assess the absorption, distribution, metabolism, and excretion processes of a drug and has proven its usefulness in predicting even complex interaction scenarios. The objectives of the presented work were to develop a PBPK model of quinidine and to integrate the model into a comprehensive drug–drug(–gene) interaction (DD(G)I) network with a diverse set of CYP3A4 and P‐gp perpetrators as well as CYP2D6 and P‐gp victims. The quinidine parent‐metabolite model including 3‐hydroxyquinidine was developed using pharmacokinetic profiles from clinical studies after intravenous and oral administration covering a broad dosing range (0.1–600 mg). The model covers efflux transport via P‐gp and metabolic transformation to either 3‐hydroxyquinidine or unspecified metabolites via CYP3A4. The 3‐hydroxyquinidine model includes further metabolism by CYP3A4 as well as an unspecific hepatic clearance. Model performance was assessed graphically and quantitatively with greater than 90% of predicted pharmacokinetic parameters within two‐fold of corresponding observed values. The model was successfully used to simulate various DD(G)I scenarios with greater than 90% of predicted DD(G)I pharmacokinetic parameter ratios within two‐fold prediction success limits. The presented network will be provided to the research community and can be extended to include further perpetrators, victims, and targets, to support investigations of DD(G)Is.
Metal–Organic Framework–Derived Mesoporous B‐Doped CoO/Co@N‐Doped Carbon Hybrid 3D Heterostructured Interfaces with Modulated Cobalt Oxidation States for Alkaline Water Splitting
Authors: Cha Dun Chan , Singh Thangjam Ibomcha , Maibam Ashakiran , Kim Tae Hyeong , Nam Dong Hwan , Babarao Ravichandar , Lee Seunghyun 
Published: May 2023

AbstractHeteroatom‐doped transition metal‐oxides of high oxygen evolution reaction (OER) activities interfaced with metals of low hydrogen adsorption energy barrier for efficient hydrogen evolution reaction (HER) when uniformly embedded in a conductive nitrogen‐doped carbon (NC) matrix, can mitigate the low‐conductivity and high‐agglomeration of metal‐nanoparticles in carbon matrix and enhances their bifunctional activities. Thus, a 3D mesoporous heterostructure of boron (B)‐doped cobalt‐oxide/cobalt‐metal nanohybrids embedded in NC and grown on a Ni foam substrate (B‐CoO/Co@NC/NF) is developed as a binder‐free bifunctional electrocatalyst for alkaline water‐splitting via a post‐synthetic modification of the metal–organic framework and subsequent annealing in different Ar/H2 gas ratios. B‐CoO/Co@NC/NF prepared using 10% H2 gas (B‐CoO/Co@NC/NF [10% H2]) shows the lowest HER overpotential (196 mV) and B‐CoO/Co@NC/NF (Ar), developed in Ar, shows an OER overpotential of 307 mV at 10 mA cm−2 with excellent long‐term durability for 100 h. The best anode and cathode electrocatalyst‐based electrolyzer (B‐CoO/Co@NC/NF (Ar)(+)//B‐CoO/Co@NC/NF (10% H2)(−)) generates a current density of 10 mA cm−2 with only 1.62 V with long‐term stability. Further, density functional theory investigations demonstrate the effect of B‐doping on electronic structure and reaction mechanism of the electrocatalysts for optimal interaction with reaction intermediates for efficient alkaline water‐splitting which corroborates the experimental results.
Adaptive solving strategy synthesis for symbolic execution
Authors: Chen Zhenbang , Zhang Guofeng , Chen Zehua , Shuai Ziqi , Pan Weiyu , Zhang Yufeng , Wang Ji 
Published: May 2023

SummaryConstraint solving is the enabling technique for symbolic execution. The advancement of constraint solving boosts the development and application of symbolic execution. Modern Satisfiability Modulo Theories (SMT) solvers provide the mechanism of solving strategy, allowing users to control the solving procedure. This mechanism significantly improves the solver's generalization ability. We observe that the symbolic executions of different programs are different constraint solving problems. Therefore, we propose synthesizing solving strategies for a program to fit the program's symbolic execution best. To achieve this, we propose an adaptive framework for synthesizing solving strategies, in which the constraints are classified into different categories, and the solving strategies are synthesized for different categories on demand. We propose novel synthesis algorithms that combine the offline trained deep learning models and online tuning to synthesize the solving strategy. The algorithms balance the synthesis overhead and the improvement achieved by the synthesized solving strategy. We have implemented our method on the state‐of‐the‐art symbolic execution engine KLEE for C programs and Symbolic Pathfinder (SPF) for Java programs. The results of the extensive experiments indicate that our method effectively improves the efficiency of symbolic execution. For the Coreutils benchmark, our method, on average, increases the numbers of paths and queries by 74.37% and 73.94% under Breadth First Search (BFS), respectively. Besides, we applied our method to a different benchmark of C programs and a benchmark of Java programs to validate the generalization ability. The results demonstrate that for the C benchmark, our method increases the numbers of paths and queries by 71.09% and 70.60% under BFS, respectively; For the Java benchmark, our method increases the numbers of paths and queries by 50.31% and 49.93% under BFS, respectively. These results show that our method has a good generalization ability.
Developing RRI and Research Ethics in Universities
Authors: Bernal-Sánchez Laura , Feenstra Ramón A. 
Published: May 2023

AbstractThis work examines the process of developing responsible research and innovation (RRI) at Universitat Jaume I, a public university in Castelló Spain. In this context, the chapter presents some basic characteristics of RRI implementation by exploring thestepsin the process, and some barriers and drivers. In particular, the authors examine the development of a code of good research practice and the university’s ethics committees. Both tools are developed in line with the European ETHNA System project, which provides practical guides for RRI institutionalisation processes.
Does the peer-led Honest, Open, Proud program reduce stigma’s impact for everyone? An individual participant data meta-regression analysis
Authors: Klein Thomas , Kösters Markus , Corrigan Patrick W. , Mak Winnie W. S. , Sheehan Lindsay , Conley Colleen S. , Oexle Nathalie , Rüsch Nicolas 
Published: May 2023

Abstract
Purpose
Many people with mental illness experience self-stigma and stigma-related stress and struggle with decisions whether to disclose their condition to others. The peer-led Honest, Open, Proud (HOP) group program supports them in their disclosure decisions. In randomized controlled trials, HOP has shown positive effects on self-stigma and stigma stress on average. This study examined individual predictors of HOP outcomes and tested the hypothesis that stigma stress reduction at the end of HOP mediates positive HOP effects at follow-up.

Methods
Six RCTs were included with data at baseline, post (after the HOP program) and at 3- or 4-week follow-up. Baseline variables were entered in meta-regression models to predict change in self-stigma, stigma stress, depressive symptoms and quality of life among HOP participants. Mediation models examined change in stigma stress (post) as a mediator of HOP effects on self-stigma, depressive symptoms, and quality of life at follow-up.

Results
More shame at baseline, and for some outcomes reduced empowerment, predicted reduced HOP effects on stigma stress, self-stigma, depressive symptoms, and quality of life. Younger age was related to greater improvements in stigma stress after the HOP program. Stigma stress reductions at the end of HOP mediated positive effects on self-stigma, depressive symptoms and quality of life at follow-up.

Conclusion
Participants who are initially less burdened by shame may benefit more from HOP. Stigma stress reduction could be a key mechanism of change that mediates effects on more distal outcomes. Implications for the further development of HOP are discussed.
Prevalence of pelvic floor dysfunction in recreational athletes: a cross-sectional survey
Authors: Campbell K. Gillian , Batt Mark E. , Drummond Avril 
Published: May 2023

Abstract
Introduction and hypothesis
Pelvic floor dysfunction (PFD) affects many women and participation in elite sport and high-impact exercise has been reported as a potential risk. However, few studies have investigated the effects of exercising at recreational levels on PFD. Our aim was to investigate levels of PFD in women exercising at, or above, UK guidelines for health and compare them with levels in non-exercisers.

Method
Data on levels of PFD and potential risk factors (age, hormonal status, body mass index, constipation, parity, forceps delivery, and recreational exercise) were collected using a cross-sectional survey distributed via social media. The International Consultation Incontinence Questionnaire (ICIQ) Urinary Incontinence Short Form was used to estimate prevalence of urinary incontinence (UI). Selected questions from the ICIQ vaginal symptom and bowel symptom questionnaires were used to estimate prevalence of anal incontinence (AI) and pelvic organ prolapse (POP). Logistic regression analysis was used to compare exercisers and non-exercisers after adjusting for potential confounders.

Results
We recruited 1,598 adult women (1,141 exercisers and 457 non-exercisers). The majority were parous. High prevalence of UI (70%), AI (52%) and POP (18%) was reported. No significant association was found between recreational exercise and PFD despite adjustment for confounders, or further investigation regarding exercise involving impact, although some increased reporting of AI was seen in those exercising for over 10 hours per week.

Conclusion
High levels of all PFD were reported but no significant association was found between recreational exercise and symptoms. However, data suggest that women modify their exercise regimes as required. Few symptomatic women sought professional help.