bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Myocardial Strain in Patients With Subclinical Hypertrophic Cardiomyopathy and Subclinical Hypertension Heart Disease Using Cardiac Magnetic Resonance Feature Tracking
Authors: Hao Xiaoyong , Wu Jiang , Zhu Lina , Li Xuan 
Published: May 2023

Abstract
The evaluation of cardiac magnetic resonance feature tracking may have great diagnostic value in hypertrophic cardiomyopathy and hypertension heart disease.To explore the diagnostic and clinical research value of cardiac magnetic resonance feature tracking in evaluation of myocardium deformation in patients with subclinical hypertrophic cardiomyopathy(SHCM)and subclinical hypertension heart disease(SHHD).CMR scans was performed on 1.5 T MR scanner in 33 patients with SHCM,31 patients with SHHD, and 27 controls(NS).The CMR image post-processing software was used to analyze the characteristics of routine cardiac function, different global and regional myocardial strain in each group.Analysis of variance (ANOVA) was used to compare age, blood pressure,heart rate,routine cardiac function,body mass index (BMI), as well as the strain between different segments within each of the three groups. If a significant difference was detected, a least significant difference (LSD) comparison was performed if there was a significant difference.The diagnostic efficacy of different parameters in differentiating SHHD from SHCM was evaluated through receiver operating characteristic (ROC) curve analysis, and determination of the best cutoff value.The routine cardiac function parameters were no statistically different among three groups (P＞0.05).There are statistical differences between the global myocardial strain parameters and the peak strain parameters of some segments,especially the basal segment, in each group (P＜0.05), and the Global radial peak strain(GRPS) can be used to distinguish SHCM from SHHD group (The area under the ROC curve was 0.885), which is the best diagnostic performance.Cardiac magnetic resonance feature tracking can detect left ventricular deformation in patients with SHCM and SHHD group.The abnormality of strain has important research value for its subclinical diagnosis and clinical evaluation.
Influence of Yb3+ ION Percentage on the Emission of Er3+ ION Doped Into GdVO4 Matrix
Authors: Ferreira Maria Fernanda , Faria João Vitor Gonçalves , Pontes Lauany Mazzon , Crespi Marcela Guedes Matos , Rocha Lucas Alonso , Nassar Eduardo José 
Published: May 2023

Abstract

In this study the non-hydrolytic sol gel methodology was used to synthesized gadolinium vanadate particles doped with different molar ratios of the Er3+ and Yb3+ ions. The sol gel synthesis, lanthanide ion chlorides and vanadium alkoxide were used as precursors. The resulting powders were treated at 800 oC and characterized by X-ray diffraction and photoluminescence properties. The X-ray diffractogram displayed peaks attributed to the gadolinium vanadate matrix. Photoluminescence helped to evaluate the Fluorescence Intensity Ratio (FIR), parameter for understanding the nanothermometer property. The FIR of the GdVO4: Er3+/Yb3+ samples containing different molar ratios of the Er3+ and Yb3+ ions increased as a function of laser power, which indicated that the local temperature increased. The excitation spectra obtained at fixed wavelengths of 525 and 555 nm displayed bands at 322, 379, and 489 nm, ascribed to the charge transfer band and Er3+ ion levels. Upon excitation at 322 nm, the emission spectra in the visible region presented intense bands at 525 and 555 nm, due to Er3+ ion emission, and excitation at 322 nm, the emission in the infrared region, 980 and 1550 nm, were observed. The system is a candidate can be employed as temperature sensor.
Integrally Private Model Selection for Deep Neural Networks
Authors: Varshney Ayush K. , Torra Vicenç 
Published: May 2023

Abstract
Deep neural networks (DNNs) are one of the most widely used machine learning algorithm. In the literature, most of the privacy related work to DNNs focus on adding perturbations to avoid attacks in the output which can lead to significant utility loss. Large number of weights and biases in DNNs can result in a unique model for each set of training data. In this case, an adversary can perform model comparison attacks which lead to the disclosure of the training data. In our work, we first introduce the model comparison attack for DNNs which accounts for the permutation of nodes in a layer. To overcome this, we introduce a relaxed notion of integral privacy called $\epsilon$-integral privacy. We further provide a methodology for recommending $\epsilon$-Integrally private models. We use a data-centric approach to generate subsamples which have the same class-distribution as the original data. We have experimented with 6 datasets of varied sizes (10k to 7 million instances) and our experimental results show that our recommended private models achieve benchmark comparable utility. We also achieve benchmark comparable test accuracy for 4 different DNN architectures. The results from our methodology show superiority under comparison with three different levels of differential privacy.
YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression
Authors: Xiao Yao , Zhou Lilni , Andl Thomas , Zhang Yuhang 
Published: May 2023

Abstract
Epithelial-to-mesenchymal transition (EMT) is crucial for melanoma cells to escape keratinocyte control, invade underlying dermal tissues, and metastasize to distant organs. The hallmark of EMT is the switch from epithelial cadherin (E-cadherin) to neural cadherin (N-cadherin), allowing melanoma cells to form a homotypic N-cadherin-mediated adhesion with stromal fibroblasts. However, how “cadherin switching” is initiated, maintained, and regulated in melanoma remains unknown. Here, we show that upon Yes-associated protein 1 (YAP1) ablation in cancer-associated fibroblasts (CAFs), the progression of a BRAF-mutant mouse melanoma was significantly suppressed in vivo, and overexpressing YAP1 in CAFs accelerated melanoma growth. CAFs require YAP1 function to proliferate, migrate, remodel the cytoskeletal machinery and matrix, and promote cancer cell invasion. By RNA-Seq, N-cadherin was identified as a major downstream effector of YAP1 signaling in CAFs. YAP1 silencing led to N-cadherin downregulation in CAFs, which subsequently induced the downregulation of N-cadherin in neighboring melanoma cells. N-cadherin downregulation inhibited the PI3K-AKT signaling pathway in melanoma cells and suppressed melanoma growth in vivo, supporting the role of N-cadherin as an adhesive and signaling molecule in melanoma cells. This finding suggests that YAP1 depletion in CAFs induces the downregulation of p-AKT signaling in melanoma cells through the N-cadherin-mediated interaction between melanoma cells and CAFs. Importantly, our data underscore that CAFs can regulate N-cadherin-mediated interactions with melanoma cells. Thus, disentangling cadherin-mediated cell‒cell interactions can potentially disrupt tumor-stroma interactions and reverse the tumor cell invasive phenotype.
Photobiocatalytic Conversion of Solar Energy to NH3 from N2 and H2O
under Ambient Condition
Authors: Ohsaki Yutaka , Shen Xiao-feng , Watanabe Motonori , Song Jun Tae , Ishihara Tatsumi , kosem Nuttavut 
Published: May 2023

Abstract
Several methods and catalysts have been investigated for eco-friendly ammonia (NH3) production under mild conditions in the past few decades. NH3 is important chemical fertilizer and now expecting as H2 carrier, and mainly synthesized by Haber-Bosch process under severe conditions (400 ℃, 20MPa). In contrast, nitrogenases, biocatalyst can activate N2 and H2O to form NH3 under ambient conditions in nature with a low synthesis rate. Herein we first reported photobiocatalytic NH3 production by the combination of cyanobacterial Anabaena variabilis as a whole-cell biocatalyst coupled with TiO2 as a photocatalyst in the existence of glycerol as a sacrificial reagent and viologens as an electron transfer mediator. Comparing with natural system, the formation rate of NH3 from a combination with inorganic photocatalyst was much increased by ca. 20.86 times. Biocatalytic reactions revealed that only reduced MV•+ passed into whole cells and transfer electrons to nitrogenase efficiently for NH3 production. The amount of intracellular [MoFe]-nitrogenase was increased in cyanobacteria cultivated in a nitrogen-deficient Allen & Arnon medium. The complete hybrid system produced NH3 with a maximum rate of 3.3 µM·g-1·h-1. This study is the first demonstration of the sustainable technology for solar-to-NH3 conversion as an energy carrier for a future carbon-neutral energy society.
Phytochemical profiling and GC-MS analysis of methanol extract of Spinifex littoreus(Burm. f.) Merr
Authors: Purushothaman Ramamoorthy , Vishnuram Ganapathy , Ramanathan Thirugnanasambandam 
Published: May 2023

Abstract
Coastal sand dune plants are of great importance to researchers in the field of pharmacology, medicinal, industrial, nutritional, and ecosystem restoration. Nowadays most of the pharmaceutical industries depend on the medicinal plant for their raw materials for drug discovery. Spinifex littoreus is a coastal plant under the family Poeaceae growing on the sandy seashore and is well known for its medicinal properties. The present study was carried out to the phytochemical screening and estimated the bioactive components present in the methanolic extract of Spinifex littoreus leaves. The phytochemical studies revealed the presence of flavonoids, saponins, alkaloids, terpenoids, tannins, and phenols. The GC-MS analysis revealed the presence of twenty bioactive compounds which include n-Hexadecanoic acid, 9,10-Secochola-5,7,10(19)-trien-24-al, 3-hydroxy-(3.beta.,5Z,7E), and 1,3-Benzenedicarboxylic acid, etc., The phytochemical and GC-MS profiling of the methanol extract of Spinifex littoreus leaves revealed the presence of bioactive compounds with important medicinal properties. Hence, the presence of these phytochemicals could be responsible for the therapeutic effects of the plant.
Rhizosphere microbial community dynamics contribute to nitrogen fixation and forage quality in novel perennial intercrops in Rwanda
Authors: Schaedel Marie , Majuga Jean Claude Noel , Ishii Satoshi , Jungers Jacob , Paul Birthe , Mutimura Mupenzi , Mwendia Solomon 
Published: May 2023

Abstract

In low-fertility tropical agroecosystems, intercropping with perennial legumes has the potential to maximize biological nitrogen fixation (BNF) and improve non-legume nitrogen (N) uptake and yields. However, the microbial interactions that facilitate the beneficial effects of intercropping in perennial systems remain largely uncharacterized, particularly in the tropics. In this study, we explored the contribution of root-associated bacteria and fungi to N content and the nutritional characteristics of perennial grasses (Cenchrus purpureus and Brachiaria cv. Mulato II) and an annual cereal (Zea mays) intercropped with a perennial legume (Desmodium sp). Sampling approximately every 8 weeks at the time of forage grass anthesis, we collected biomass leaf tissue, bulk soil, and rhizosphere soil. We calculated nitrogen derived from the atmosphere (Ndfa) in Desmodium leaf tissue to estimate BNF and found that Ndfa increased in intercropping arrangements relative to single-cropped Desmodium by 91.6–147.1% on average in intercropped stands with Brachiaria and C. purpureus. Intercropping also induced positive changes in non-legume tissue quality in a species- and site-dependent manner. Furthermore, we identified microbial taxa that were significantly enriched in the rhizosphere of intercropped plants relative to monocropped plants and which correlated to multiple forage nutritive quality metrics. Fungal community structure responded more strongly to the presence of a legume intercrop than bacterial communities. We also identified species-specific trends in the degree to which monocropped and intercropped rhizosphere communities differed. Overall, this study suggests that perennial legume intercropping may recruit beneficial rhizosphere microorganisms in rainfed tropical soils to facilitate nutritional benefits in the non-legume companion crop and highlights the complexity of rhizospheric microbial interactions in intercropped systems.
Assessment of WASH infrastructure in schools in Central Sulawesi, Indonesia using structured observations and principal interviews
Authors: Ahmed Imaduddin , Garfias Royo Margarita , Opabola Eyitayo , Nurdin Sukiman , Meilianda Ella , Idris Yunita , Rusydy Ibnu , Joffe Helene , Parikh Priti 
Published: May 2023

Abstract
Adequate water, sanitation, and hygiene (WASH) facilities in schools are vital, especially for girls. This study addresses a gap in assessing the adequacy of WASH facilities' repair at schools affected by natural hazards. Central Sulawesi was used as a case study where principal interviews were conducted at 26 schools, and structured observations were made at 18 schools, 3 years after the earthquake in September 2018. Ten of 26 principals reported no damage to the toilets from the events of September 2018. Among those who did, a third felt that the fixes insufficiently met basic needs and that they did not deliver WASH services as well as they used to. Not all WASH inadequacy stemmed from the earthquake. Structured observations revealed that most toilets lacked soap, open water reserves were placed next to non-flush latrines, posing a high potential for vector-breeding, and there were inadequate facilities for menstrual hygiene management, including no bins. Recommendations include ensuring a supply of soap, adding lids to water storage containers, and providing sanitary napkins and lidded bins. Observations suggested that private schools provided a better level of WASH service than state schools, and schools in more hazardous zones did not take longer to recover.
Research Progress of α-Synuclein Aggregation Inhibitors for Potential
Parkinson’s Disease Treatment
Authors: Kalsoom Iqra , Wang Yuanhao , Li Bo , Wen Hongliang 
Published: May 2023

Introduction:
Parkinson’s disease (PD) is characterized by fibrillation of disordered proteins
known as Lewy bodies in the substantia nigra that also undergo progressive neurodegeneration.
The aggregation of α-synuclein (α-syn) is a hallmark and potentially a critical step in the development
of Parkinson’s disease and other synucleinopathies. The synaptic vesicle protein α-syn is a small,
abundant, highly conserved disordered protein and the causative agent of neurodegenerative diseases.
Several novel pharmacologically active compounds are used to treat PD and other neurodegenerative
disorders. Though, the mechanism through which these molecules inhibit the α-syn aggregation is still
not fully understood.

Objective:
This review article is focused on the recent advancements in compounds that can inhibit
the development of α-syn fibrillation and oligomerization.

Methods:
The current review article is based on the most recent and frequently cited papers from
Google Scholar, SciFinder, and Researchgate sources.

Description:
In the progression of PD, the mechanism of α-syn aggregation involves the structural
transformation from monomers into amyloid fibrils. As the accumulation of α-syn in the brain has
been linked to many disorders, the recent search for disease-modifying medications mainly focused on
modifying the α-syn aggregation. This review contains a detailed report of literature findings and illustrates
the unique structural features, structure-activity relationship, and therapeutic potential of the
natural flavonoids in the inhibition of α-syn are also discussed.

Conclusion:
Recently, many naturally occurring molecules such as curcumin, polyphenols, nicotine,
EGCG, and stilbene have been recognized to inhibit the fibrillation and toxicity of α-syn. Therefore,
knowing the α-synuclein filament's structure and how they originate will help invent particular biomarkers
for synucleinopathies and develop reliable and effective mechanism-based therapeutics. We
hope the information this review provides may help evaluate novel chemical compounds, such as α-
syn aggregation inhibitors, and will contribute to developing novel drugs for treating Parkinson’s disease.
Recent Development and Advancement in Quantum Dots in
Pharmaceutical and Biomedical Fields for the Delivery of Drugs
Authors: Singh Pranjal Kumar , Singh Smita , Sachan Kapil , Verma Vikrant , Garg Sakshi 
Published: May 2023

Abstract:
Nanoscale semiconductors known as quantum dots (QDs) are essential for drug testing
because they bridge the gap between nanotechnology and the testing of drugs. QDs are a valuable
tool in theranostics and treatment because of their unique physicochemical features. Due to their
photoluminescence and electronic properties, including broad and continuous absorption spectra,
narrow emission spectra from visible to near-infrared wavelengths, and long-lasting and high
brightness, they are suitable probe materials for use in (bio)sensing (immunological) platforms.
Several studies use QDs due to their optical, magnetic, electrical, photochemical, and biological
features that allow them to be employed in various scientific domains. When utilized in drug delivery
systems, fluorescent markers, such as QDs, can track the metabolism of drugs in the human
body. Many medicinal applications, such as disease diagnosis and medication research, can benefit
from these fluorescent tests. In this review article, the application of QD in drug delivery and
immunoassay sensing has been described in detail.
Role and Application of Nanostructures in Biotechnology
Authors: Rani Nidhi , Sharma Prerna , Gangwar Aishwarya , Verma Inderjeet , Walia Aditya 
Published: May 2023

Abstract:
Nanotechnology is a major area of research entitling the production of an utmost different class
of materials. There are various types of nanostructures, such as nanoparticles, nanocrystals, nano spores,
nanorods, nanowires, nanoribbons, nanotubes, nano scaffolds, dendrimers, quantum dots, nanospheres,
and nanocapsules. These are size-dependent; thus, altering their size and shape to the nanoscale can alter
their properties. Also, they can be manufactured via various different methods. On a wider scale, in combination,
nanostructured materials and nanotechnology can have profound impacts, including biomedical
applications with advanced research in the delivery of biomolecules, the delivery of drugs, the diagnosis
of cancer, tissue engineering, the detection of biomarkers and imaging. These materials have numerous
applications in fabricating biotechnology, an advanced area of research.
A Photovoltaic-based Novel Transformerless High Gain Converter for DC
Microgrid Applications
Authors: Ramasamy Kannan , Subramani Pragaspathy , Venkitusamy Karthikeyan , Kadali Kalyan Sagar , Sankaranarayanan Saravanan , Ganesh Motepalli Siva Rama 
Published: May 2023

Aim:
A typical microgrid network sourced by renewable energy encounters a technical
setback owing to the voltage imbalance across the source integration and load power dissemination.
Transformers employed to stabilize the potential may deteriorate the network efficiency and
increases the cost and size of the system as well.

Introduction:
Photovoltaic based transformerless high gain DC-DC converter (THG-DC) is proposed
here to aid the microgrid infrastructure. Microgrid fuelled by renewable energy sources demands
the high gain converter interface to boost low voltage generation. The proposed THG-DC is
employed with four switched inductors and three active power switches (IGBT) which are brought
together under dual leg configurations.

Methods:
The proposed topology offers dual-duty cycle modes of regulating the active switches to
realize the desired output voltage. Moreover, it is reliable to drive the proposed THG-DC with
lower values of duty cycles to achieve a higher gain. The voltage stress across the switches is minimized
and the magnitude of inductor current ripples is quashed to an extent. The proposed THGDC
is simple in architecture and easy to control in all three operating modes.

Results:
The operating characteristics and performance investigation of the novel converter during
the continuous and discontinuous modes are elucidated briefly and the comparative analysis on
switching stress, gain, and efficiency are executed to justify the standards of the proposed THGDC.

Conclusions:
Finally, the miniature prototype model is experimented with in the laboratory (0.3
kW) and the obtained results are in agreement with the theory. It is evident from the investigations
that the proposed THG-DC shows its dominance over other converters on the voltage gain, switching
stress, number of components, and overall efficiency.
Determination of the coordinates of the axis of engineering communications by satellite method
Authors: Ovchinnikova N. G. , Nicenko I. A. 
Published: May 2023

The satellite method of determining coordinates has both positive and negative sides. The main advantages of using satellite methods for determining coordinates are high productivity, speed of processing and obtaining results, automation of the process, no need for line of sight, laying points in convenient places, a wide range of accuracy, round-the-clock use, the ability to determine coordinates and heights simultaneously.
When using satellite equipment to determine coordinates, some disadvantages can be identified: the inability to use near reinforced concrete buildings, structures, canopies, in the foliage of trees that impair signal reception, as well as signal distortion near ground-based radio signal sources, the inability to use satellite equipment underground, dependence on weather conditions and the occurrence of errors, related to the rereflection of the satellite signal from surrounding objects.
Constitucionalización del Derecho Aduanero
Authors: González López Jully Pauliny 
Published: May 2023

En el año 1991, Colombia transformó su modelo de Estado con la adopción de una nueva Constitución, esto permitió que las diferentes ramas del Derecho debieran sujetarse a los parámetros axiológicos propuestos bajo el Estado Social de Derecho, toda vez que el artículo 4 de la carta magna señala que ninguna norma del ordenamiento jurídico puede estar en contravía con la misma. La constitucionalización trajo como consecuencia una interpretación de las normas ajustada a estos postulados, principios y valores. Ante este panorama, el derecho civil, penal, comercial entre otros se han desarrollado bajo la influencia de los postulados constitucionales. En lo referente al Derecho Aduanero su desarrollo se ha marcado por la influencia del derecho tributario, aspecto que suscitó diferentes posiciones por los tratadistas al determinar la autonomía del Derecho Aduanero frente a otras especialidades, sin embargo, la regulación aduanera y su desarrollo debe ajustarse a la estructura que fundamenta y orienta el Estado Social de Derecho y a aquellas disposiciones internacionales que pretenden la armonización de los procesos y trámites aduaneros, que tienen como propósito beneficiar y fomentar el comercio internacional.