bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROGNOSTIC ROLE OF RESIDUAL TUMOR FEATURES IN HER2-NEGATIVE BREAST CANCER
Authors: Sivak L.A. , Lyalkin S.A. , Verevkina N.O. , Shipko A.F. 
Published: January 2023

The aim of the study was to examine the prognostic value of immunobiological markers (tumor-infiltrating lymphocytes (TILs) and their subpopulations) in residual tumor after neoadjuvant chemotherapy (NACT) completion in patients with triple negative (TNBC) and luminal B HER2-neu negative breast cancer (LBBC). Materials and Methods: The analysis of the treatment results of 59 patients with TNBC and 56 patients with LBBC with stage IIB–IIIB who received NACT was performed. The levels of TILs and their subpopulations (FOXP3+, CD4+, CD8+) in patients at the time of diagnosis in core-needle biopsy material and in residual tumor in postoperative material were studied by immunohistochemical method. Results: The risk of recurrence in patients with LBBC who received NACT before surgery is associated mainly with 4 factors: FOXP3+ lymphocytes, Ki-67 index in residual tumor, the number of affected axillary lymph nodes after NACT and viable residual tumor volume. Analysis of the treatment outcome in patients with TNBC revealed that the lack of pathologic complete response (pCR) after NACT increases the risk of disease recurrence by 2.9 times, hazard ratio (HR) = 2.9 (95% confidence interval (CI) 1.4–6.1; p = 0.005) compared with patients in which pCR was achieved after NACT. It was also found that the presence of residual tumor in patients with TNBC after NACT increases the risk of death from this disease by 2.7 times (95% CI 1.0–7.1; p = 0.05). Increased intratumoral and stromal CD8+ lymphocyte counts in the residual tumor after NACT significantly reduces the risk of death from TNBC, HR = 0.6 (95% CI 0.5–0.9; p = 0.01) and HR = 0.6 (95% CI 0.4–0.9; p = 0.008), respectively. Increase in intratumoral CD4+ lymphocytes in residual tumor in the non-pCR group reduces by half the risk of death from TNBC, HR = 0.5 (95% CI 0.3–1.0; p = 0.05). Conclusion: The results of our study indicate a favorable prognostic value of TILS in residual tumor in TNBC. It is also reasonable to include the determination of the level of FOXP3+ lymphocytes in the residual tumor in the standard algorithms for stratification of risk groups.
OVARIAN TOXICITY OF FAC CHEMOTHERAPY IN RATS AND POSSIBILITY OF ITS CORRECTION WITH PLATELET-RICH PLASMA
Authors: Shamrai V.A. , Misiurko O.I. , Grebeniuk D.I. , Taran I.V. 
Published: January 2023

Aim: To compare the dynamics of changes in the hormonal status of female rats in the setting of the FAC (5-fluorouracil, doxorubicin and cyclophosphamide) chemotherapy and after local administration of platelet-rich plasma (PRP). Materials and Methods: The study was carried out on female Wistar rats treated according to the FAC chemotherapy scheme (4 courses with a 3-week interval). The ovariotoxic effect of the FAC chemotherapy was assessed by the levels of anti-Mullerian hormone, estradiol (E2) and follicle-stimulating hormone in the proestrus phase. Three weeks after the last course of chemotherapy, 5 rats were administered with local intra- and periovarian injection of PRP (triply with a 1-week interval). Results: The dynamics of all investigated hormonal markers of the ovarian reserve in experimental animals was characterized by a progressive decrease in anti-Mullerian hormone and E2 levels and an increase in follicle-stimulating hormone level. The dynamics of the studied parameters after the serial administration of PRP demonstrated an improvement in the hormonal status. Conclusion: FAC chemotherapy in the experiment causes premature ovarian failure, and local administration of PRP improves the hormonal parameters of the ovarian reserve.
EXPRESSION OF IMMUNOGLOBULIN SEQUENCES HOMOLOGOUS TO ANTI-SARS-CoV-2 ANTIBODIES AND HIV IN CHRONIC LYMPHOCYTIC LEUKEMIA CASES
Authors: Abramenko I. , Bilous N. , Chumak A. , Martina Z. , Dyagil I. , Bazyka D. 
Published: January 2023

Background: Identification of epitopes recognized by leukemic B cells could provide insights into the molecular mechanisms of B cell transformation in chronic lymphocytic leukemia (CLL). The aim of this paper was to compare nucleotide sequences of immunoglobulin heavy chain variable region (IGHV) genes in CLL with known sequences directed against antigens of different origins available in public databases. Materials and Methods: Analysis was performed in the groups of 412 unselected CLL patients with productive IGHV gene using polymerase chain reaction followed by direct sequencing. Results: Homology between CLL Ig sequences and antibodies directed against autoantigens was found in 12 patients (2.9%), homology between CLL Ig sequences and antiviral antibodies — in 35 patients (8.5%). Most of these sequences belonged to stereotypical clusters. Among the sequences that have homology to antiviral antibodies, the most prevalent were cases homologous with antibodies against HIV (14 cases, 3.4%) and SARS-CoV-2 antigens (10 cases, 2.4%). None of the patients in our cohort was HIV-infected and the study was conducted before the emergence of SARS-CoV-2 virus. Conclusions: Suggestions could be made about the possible impact of past infection of SARS-CoV-2 virus on the pathogenesis of CLL. In particular, an increase in the proportion of CLL cases with the expression of some stereotyped BCR and/or an increase of CLL risk in the long-term period after SARS-CoV-2 virus infection is not excluded. This assumption needs to be verified by epidemiological data.
EFFICACY OF AUTOLOGOUS STEM CELL TRANSPLANTATION IN ADULT BURKITT/BURKITT-LIKE LYMPHOMA: A SYSTEMATIC REVIEW
Authors: Joshi U. , Subedi R. , Nepal G. , Gyawali S. , Agrawal V. , Poudyal B.S. , Bhatt V.R. , D’Angelo Ch.R. 
Published: January 2023

Background: Burkitt and Burkitt like lymphoma (BL/BLL) are highly proliferative germinal or post-germinal B cell tumors. Few studies have evaluated the impact of autologous stem cell transplantation (ASCT) on disease outcomes. Aim: We performed a systematic review to analyze the efficacy of ASCT as frontline consolidation and for treatment of relapsed/refractory cases in adult BL/BLL. Materials and Methods: Eligible studies with clear outcome measures on the efficacy of ASCT in adult patients with BL/BLL were identified through systematic search. The overall survival (OS), progression-free survival (PFS), complete response (CR), partial response (PR), and progression/relapse were used to assess the efficacy. Results: For patients who underwent ASCT in first CR, 5-year PFS and OS ranged between 70–78% and 70–83% respectively. For relapsed/refractory disease, 5-year PFS and OS were 27% and 31%, respectively. Patients undergoing ASCT for chemoresistant disease fared poorly with 3-year OS of 7% vs 37% for chemosensitive disease (p ≤ 0.00001). The overall response rate to ASCT for patients transplanted in first CR ranged between 71% and 93% and was 37% for patients who were transplanted in disease status other than first CR. Disease progression/relapse was observed in 16–29% of the patients transplanted in first CR, and 55% to 60% in relapsed disease. Conclusion: We found insufficient evidence to support ASCT over chemotherapy alone in the first remission for adult BL/BLL. Evidence supports guidelines recommending ASCT for chemosensitive disease but suggests there is no benefit to ASCT for chemoresistant disease.
Public safety in the conditions of martial law and mental warfare
Authors: Tkachenko S. O. , Diadin A. S. 
Published: January 2023

The main purpose of the study is to develop proposals and concrete measures to strengthen public security in the conditions of martial law and mental war unleashed against Ukraine. The phenomenon of mental war during martial law and methods of influencing and countering informational attacks on the nation’s mentality have been studied. It has been established that mental warfare is an element of hybrid warfare and its informational component. Information war is a mental war, because it takes place, first of all, for people’s minds, and secondly, for their behavior.
Emphasis is placed on the obligation to seize the initiative and force the opponent to defend, otherwise they will spend all their time attacking us. The information array on the content and essence of the concepts “mentality”, “society’s mentality”, “nation’s mentality” and the risks of destructive influence on them in the interest of countering damage to public security have been studied. The mental war for people’s minds means that we must make people immune to the enemy’s “new weapons”, make the enemy’s rules ineffective and carefully leave their field, and in the long run, drag it into ours. For this, we need to create a stable and clear ideology that will provide answers to certain questions and show the path we should follow, the goal we should strive for.
The content of the main normative legal acts, which require changes and clarifications in connection with the conduct of mental warfare, has been analyzed. It has been concluded that countering external attacks on the mentality of the nation should have a system-complex nature, which includes, in particular, the organization of training of personnel of this profile in educational institutions of the Ministry of Internal Affairs of Ukraine.
Emphasis is placed on the need for a creative approach, which is always unpredictable for the enemy. It is necessary to attract to work in the information space specialists who are able to think outside the box and see the world from a different angle, to get out of the format of leaflets, wall newspapers and linear thinking, when information technologies have immersed the entire active population in the virtual world of percent for 80 % of their free time.
The concept and significance of registration and permit-licensing procedures in the activities of the National Police
Authors: Bud О. А. 
Published: January 2023

The absence of sufficient theoretical developments regarding the essence and content of registration, permit and license procedures provided by the National Police of Ukraine is emphasized. In this regard, the following research tasks were formulated: 1) to establish the specificity of the legal nature of registration and permit-licensing procedures as a public service activity of police bodies; 2) determine the content of the categories “services” and “administrative services”, as well as outline their characteristic features. The implementation of the outlined tasks is aimed at achieving the goal, which consists in forming the author’s definition of the concept of “registration and permit-licensing procedures in the activities of the National Police” and clarifying their significance for ensuring the functioning of the permit system.
Attention is focused on the presence of a set of common features of registration and permit-licensing procedures in the activities of the National Police, in particular: this is a sequence of actions regulated by current national legislation; they are carried out by a specific entity, a law enforcement agency - the National Police of Ukraine; in their essence they are a public service activity; the result of such procedures involves mandatory documentation – obtaining a document (permit or license) and/or making changes to registration documents or information databases; they mainly take place in the field of the permit system; they are implemented within the framework of the provision of paid services by police bodies; the initiators of these procedures are individuals and legal entities; they are carried out in relation to individual objects of the permit system and pyrotechnic devices, the manufacture of special devices loaded with tear and irritant substances, individual protection, active defense, the provision of services for the protection of property and citizens, as well as certain types of activities (transportation of oversized, heavy cargo, activities related to the provision of services by shooting ranges, etc.).
The author’s definition of the concept of “registration and permit-licensing procedures in the activities of the National Police” has been proposed – these are successive legalized actions of a service nature, which are carried out by police bodies in the process of providing police services, upon completion of which an individual or legal entity receives a document (permit or license), which allows you to carry out various operations with objects of the permit system, items of individual protection and active defense, or provide specific services, in particular, guarding, maintenance of shooting ranges, transportation of oversized cargo.
Definition and content of the concept of transparency of criminal justice
Authors: Heta D. S. 
Published: January 2023

Common law approaches to the modern understanding of transparency in the sphere of public administration and judiciary have been considered. On the basis of the models for the definition of this concept and its content proposed in the specialized scientific literature, the author's definition of the transparency of criminal justice has been proposed. The circle of elements included in its content has been outlined, which have been also defined. Based on the provisions of the idea of judicial transparency in general, the definition has been formulated and the main features of the concept of criminal justice transparency have been outlined. Transparency of criminal justice is a principle that includes such principles of criminal court activity as transparency, openness, publicity, publicity, access to public information, accountability.
On the basis of the analysis of criminal procedural norms that reveal the content of the principles of publicity and openness, suggestions have been made regarding: 1) increasing the degree of legal certainty of the norms that regulate the procedure for consideration by the investigating judge of a request for the conduct of secret investigative (search) actions; 2) it is necessary to take into account that the list of grounds provided for in Art. 27 of the Criminal Procedure Code of Ukraine, is not exhaustive, and/or to provide for the grounds indicated in this article, or to indicate that other cases provided for by the Criminal Procedure Code of Ukraine are possible. In this regard, it has been proposed to supplement Part 2 of Article 27 of the CPC of Ukraine with paragraph 6 as follows: “When the investigating judge considers the petitions of the investigator, agreed with the prosecutor, or the prosecutor to conduct covert investigative (search) actions, temporary access to things and documents (if there is a real threat of alteration or destruction of things or documents), as well as in case of need to ensure the seizure of property”; 3) the fact that the legislator, when setting out paragraph 1 of Part 2 of Article 27 of the CPC of Ukraine had not taken into account the fact that at the stage of pre-trial investigation the circumstances concerning the minor are also subject to consideration by the court, i.e. the investigating judge. Therefore, in such cases, one should talk about the expediency of protecting the personal interests of the suspect, who is already a minor, and not the accused. On the basis of the above, it has been proposed to set out paragraph 1, part 2 of Art. 27 of the Criminal Procedure Code of Ukraine in the following version: “If the accused or suspect is a minor”.
Nerve Stimulation: Sebuah Inovasi Terbaru sebagai Alternatif Pengobatan Gangguan Pemusatan Perhatian dan Hiperaktivitas
Authors: Sean Sherlyn , Siyulan Jennifer Rachel , Heriyanto Michella Chiara , Surilena  
Published: January 2023

Pendahuluan: Gangguan pemusatan perhatian dan hiperaktivitas (GPPH) masih menjadi masalah kesehatan jiwa di dunia dan angka kejadian GPPH masih cukup tinggi di Indonesia. Hingga kini, standar regimen yang digunakan adalah farmakoterapi dengan obat golongan psikostimulan yang dinilai kurang baik karena memiliki berbagai efek samping. Sebagai alternatif, terdapat inovasi terbaru, yaitu nerve stimulation, yang merupakan sebuah prosedur non-invasif dan dapat ditoleransi dengan baik. Nerve stimulation dapat dilakukan melalui rangsangan elektrik pada saraf trigeminus (Trigeminal Nerve Stimulation) dan saraf vagus (Vagus Nerve Stimulation).
Tujuan: Mencari terapi alternatif dengan efektivitas tinggi dan efek samping minimal dalam tatalaksana GPPH.
Metode: Pada literature review ini, dilakukan penelusuran kata kunci “nerve stimulation”, “transcutaneous vagus nerve stimulation”, “trigeminal nerve stimulation”, dan “GPPH” melalui beberapa search engine. Setelah itu, dilanjutkan dengan skrining dimana diperoleh 6 jurnal yang selanjutnya ditinjau secara seksama.
Pembahasan: Pasien dengan GPPH mengalami gangguan regulasi neurotransmitter dimana terdapat penurunan dopamin, GABA dan norepinefrin. Penggunaan nerve stimulation dipercaya dapat menjadi terapi efektif untuk pasien GPPH. Uji klinis terhadap nerve stimulation pada saraf trigeminus telah menunjukan penurunan nilai ADHD-IV Rating Scale dan Conners Global Index. Stimulasi saraf vagus juga menunjukkan peningkatan produksi neurotransmitter GABA dan norepinefrin dengan cara merangsang beberapa regio di otak terutama nucleus tractus solitarius dan locus coeruleus.
Kesimpulan: Salah satu terapi mutakhir yang dapat digunakan dalam pengobatan GPPH adalah dengan menggunakan alat nerve stimulator. Secara keseluruhan, nerve stimulation memberikan efek yang baik pada pengobatan GPPH. Terapi nerve stimulation relatif aman dengan efek samping minimal yang dapat ditoleransi pada mayoritas individu.
Potensi Tepung Ampas Tebu sebagai Bahan Pembuatan Bagasse Biscuits untuk Terapi Konstipasi
Authors: Firjatu Putri Chalya , Sitompul Dea Syafira Alamsyah , Azzahra Shafa Rizki , Siregar Zahra Arridhani 
Published: January 2023

Background: Bagasse is a by-product of the sugarcane process. In Indonesia, bagasse is rarely used as a raw material for making food. Sugarcane bagasse is high in fiber. On the other hand, high rate of constipation in Indonesia requires a high-fiber food product solution. Objectives: This study aims to determine whether bagasse flour can be used as an ingredient for Bagasse Biscuits, to find out the level of people's preferences, the nutritional content of Bagasse Biscuits, and its correlation to constipation. Methods: This study consisted of three treatments, P1, P2, and P3 respectively at 100%, 50%, and 20% of bagasse flour. The research started by collecting recipes of biscuit literature. The literature is used as a reference to get the right recipe. Before the biscuits are made, the bagasse flour tested in laboratory to determine its nutritional content. Then, the biscuit organoleptic test was carried out to 50 respondents by distributing questionnaires containing assessments of taste, texture, color, and aroma. Furthermore, laboratory tests were conducted on biscuits with the highest organoleptic test values. Results: Bagasse flour contains 30.62% carbohydrates, 1.71% protein, 49.51% fiber, and 0.29% fat. Based on the organoleptic test, it was found that respondents preferred Bagasse Biscuits P3 with a taste aspect of 3.96 (delicious), texture 3.12 (soft), color 3.94 (beige chocolate), and aroma 3.96 (strong biscuit aroma). The nutritional content test was carried out on Bagasse Biscuits P3, carbohydrates 11.82%, protein 8.9%, fiber 32.39%, and fat 25.73%. Conclusion: bagasse waste which is processed into flour can be used as an ingredient for making Bagasse Biscuits because it contains carbohydrates, protein, fiber, and fat. The fiber content is possible to overcome constipation.
Keywords : Sugarcane Bagasse, Biscuits, Constipation
Analisis Swot Dalam Meningkatkan Market Share Produk Lembaga Keuangan Syari'ahdi Bmt Nu Cabang Pasean Pamekasan
Authors: Abd. Rosyid  , Abdul Kadir  , Nanik Widyaningsih  
Published: January 2023

BMT NU Cabang Pasean adalah lembaga keuangan syari’ah yang telah ambil bagian dalam resolusi ekonomi mikro yang menyentuh masyarakat level bawah. Dalam realisasinya BMT NU “menjual” produk-produk yang dapat menfasilitasi kebutuhan masyarakat.
Dalam rangka menjaga stabilitas lembaga semestinya sebuah lembaga memiliki strategi marketing sehingga produk-produk lembaga dimaksud tetap berdaya saing dipasaran. Pun demikian BMT NU Cabang Pasean, sebagai lembaga yang menjadi bagian dari lembaga besar berkala regional tentu telah memiliki produk-produk yang sudah landing dan ikut serta dalam persaingan pasar.
Pertanyaan paling mendasar adalah bagaimana BMT NU Cabang Pasean menjaga stabilitasnya dipasaran serta mengembangkan perannya dalam kegiatan usaha mikro. Penelitian ini akan memberikan bagaimana market share yang dilakukan oleh BMT NU dan apa saja prasarana yang digunakan didalam mempertahankan peran dan fungsinya ditengah-tengah masyarakat.
Retraction of published article due to the author's proposal, 2021, Vol. 9, No. 3, pp. 1-17
Authors: Osadchyi Viacheslav 
Published: January 2023

The Editorial Board of Ukrainian Journal of Educational Studies and Information Technology, announces the formal retraction of the following article:
Olifer, O. (2021). The characteristics and philosophical foundations of the learner-centered paradigm of education. Ukrainian Journal of Educational Studies and Information Technology, 9(3), 1–17. https://doi.org/10.32919/uesit.2021.03.01
ПОРЯДОК ВИЗНАЧЕННЯ РІВНЯ НАВЧЕНОСТІ КОРИСТУВАЧІВ ІНФОРМАЦІЙНИХ СИСТЕМ УПРАВЛІННЯ ОБОРОННИМИ РЕСУРСАМИ ЗБРОЙНИХ СИЛ УКРАЇНИ
Authors: Галаган Віктор , Бондарчук Сергій , Полішко Сергій , Васюхно Станіслав 
Published: January 2023

Стаття присвячена питанням визначення рівня навченості користувачів інформаційних систем управління оборонними ресурсами ЗС України. Наведений загальний порядок підготовки користувачів до роботи з інформаційними системами та на його основі удосконалена методика визначення рівня навченості посадових осіб, які будуть працювати з даними інформаційними системами.
Удосконалена методика може бути застосована в навчальному процесі підготовки фахівців з питань інформаційних технологій у вищих військових навчальних закладах та користувачів (посадових осіб) інформаційних систем воєнного призначення.
ШЛЯХИ УДОСКОНАЛЕННЯ УПРАВЛІННЯ ВИЩИМ ВІЙСЬКОВИМ НАВЧАЛЬНИМ ЗАКЛАДОМ
Authors: Дудурич Василь , Курило Олег 
Published: January 2023

Анотація: у статті розглянуто шляхи удосконалення управління вищим військовим навчальним закладом з урахуванням сучасних тенденцій демократизації освітньої сфери.
Розглянуто шляхи удосконалення управління вищим військовим навчальним закладом серед яких виділено: врахування ідей синергетичного підходу; перехід керівника на демократичний стиль керівництва; делегування повноважень керівників окремим співробітникам і колегіальним органам; розвиток колегіальних основ діяльності керівника; мотивування співробітників на виконання управлінських функцій в процесі делегування їм управлінських повноважень; упорядкування контролю викладачів ВВНЗ; визначення керівником ВВНЗ посадових обов'язків підлеглих з урахуванням їх інтересів та потенційних можливостей.
Напрями подальших наукових розвідок доцільно зосередити на дослідженнях перспективних шляхів демократизації управлінських процесів в системі вищої військової освіти.