bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Sistem Jaminan Produk Halal Bagi Kelompok Usaha Mikro Kecil Menengah Banyumas
Authors: Afifah Dini Nur , Pamungkas Regawa Bayu , - Istianah , Mulyanto Arif 
Published: February 2023

Indonesia telah mencanangkan program sertifikasi halal sejak tahun 2014. Program ini dimaksudkan untuk memberikan kepastian kehalalalan sehingga konsumen muslim terhindar dari produk haram. Ketentuan mengenai jaminan halal tercantum dalam undang undang Nomor 33 tahun 2014 tentang Jaminan Produk Halal (JPH). Dalam Undang-undang tersebut ditegaskan bahwa produk yang masuk, beredar, dan diperdagangkan di Indonesia wajib bersertifikasi halal (Pasal 4), oleh karena itu pemerintah bertanggung jawab dalam menyelenggarakan JPH (Pasal 5). Selanjutnya, kebijakan tentang halal dikuatkan dan dimudahkan pelaksanaannya melalui UU No. 11 Tahun 2020 tentang Cipta Kerja. Semua produk yang beredar di Indonesia wajib bersertifikat halal pada tahun 2024. Melalui kedua undang-undang tersebut dapat dipahami bahwa produk pangan yang bersertifikasi halal memiliki potensi pasar yang lebih luas dibanding produk yang belum bersertifiaksi halal. Selain perusahaan besar, produk makanan dan minuman yang beredar di Indonesia juga diproduksi oleh usaha kecil mikro kecil dan menengah (UMKM). Usaha kecil mikro kecil dan menengah (UMKM) merupakan jenis usaha yang terbukti sangat kokoh menghadapi berbagai goncangan ekonomi. Pemulihan ekonomi nasional secara cepat dapat dilakukan dengan menggulirkan kembali roda UMKM. Berdasarkan data yang terhimpun di Asosiasi Pengusaha Mikro Kecil dan Menengah Banyumas (ASPIKMAS), jumlah pengusaha UMKM di Banyumas mencapai kurang lebih 3500 orang. Jumlah ini menghasilkan produk makanan dan minuman yang cukup banyak. Sebagian kecil produk sudah memiliki sertifikat halal dari MUI, namun sebagian besar dari produk makanan dan minuman yang dipasarkan saat ini belum mendapatkan sertifikat halal dari BPJPH. Kendala utama dari permasalahan ini adalah, umumnya anggota ASPIKMAS belum memiliki wawasan yang cukup mengenai ruang lingkup kegiatan yang dapat memudahkan untuk mendapatkan sertifikasi halal. Beberapa upaya telah dilakukan Asosiasi dalam membina anggota melalui pertemuan dan kegiatan pelatihan rutin. Namun demikian karena jumlahnya yang banyak dan tersebar, maka masih dipandang perlu untuk melakukan kolaborasi dengan institsusi pendidikan agar akselerasi pembinaannya semakin cepat. Oleh karena program IbM ini bekerjasama dengan ASPIKMAS mengadakan kegiatan pelatihan sistem jaminan produk halal. Hasil evaluasi kegiatan IbM menunjukkan bahwa pelatihan dapat meningkatkan kemampuan UMKM dalam menyusun sistem jaminan produk halal. Hal ini dapat dievaluasi dari peningkatan hasil rata-rata post-test yang mencapai 81 poin. Nilai ini naik 31 % dibandingkan sebelum peserta mengikuti pelatihan.
Penerapan Pemasaran Digital pada Panti Asuhan Muhammadiyah Griya Al Falah Purbalingga, Jawa Tengah
Authors: Hamka Muhammad , Muktiadi Ridho , - Tukiran 
Published: February 2023

pandemi COVID-19. Mayoritas pelaku usaha menyatakan penggunaan internet untuk pemasaran dan transaksi online memiliki pengaruh sangat signifikan. Panti asuhan Griya Al Falah Purbalingga, Jawa Tengah memiliki salah satu program pengembangan wirausaha bagi anak asuhnya. Kendala yang dihadapi panti asuhan Griya Al Falah adalah kurang luasnya jangkauan pemasaran serta rendahnya tingkat penjualan. Kegiatan Ipteks bagi Masyarakat (IbM) ini bertujuan meningkatkan kemampuan mitra dalam memanfaatkan TI untuk adaptasi proses bisnis berbasis TI serta meningkatkan nilai penjualan produk, meningkatkan jaringan pemasaran dan promosi produk melalui media sosial. Metode yang digunakan adalah diskusi, paparan mengenai pentingnya penerapan digital marketing, elemen-elemen di dalam digital marketing, san langkah-langkah penerapan digital marketing. Metode lainnya adalah workshop implementasi digital marketing melalui media sosial dan aplikasi marketplace. Berdasarkan hasil evaluasi kegiatan, IbM ini telah berjalan sesuai rencana dan memenuhi harapan mitra. Hal tersebut ditunjukkan berdasarkan peserta yang menjawab “Sangat Setuju” mencapai 22,10 %, jawaban bernilai “Setuju” adalah 76,24%, sedangkan jawaban “Ragu-Ragu” adalah 1,66%. Sedangkan evaluasi untuk mengetahui minat peserta untuk mengubah model bisnisnya menggunakan digital business atau digital marketing sesuai hasil angket adalah, peserta yang setuju dan akan tetapi masih memiliki keraguan 67,56%, sedangkan peserta yang sudah memiliki keyakinan bahwa digital business akan meningkatkan nilai penjualan mencapai 15,56 %. Adapun peserta yang masih mempertimbangkan pemanfaatan Teknologi Informasi khususnya jaringan internet dalam penjualan sejumlah 16 %. Sementara itu, peserta yang bertahan dengan penjualan konvensional dan tidak ingin beralih ke digital marketing hanya 0,89%.
العلاقات العثمانية الروسية في إطار مؤتمر برلين الأول 1878 م
Authors: محمد صديق الزيباري دلاور , فليح عيال غادة 
Published: February 2023

سعت روسيا إلى التدخل في شؤون الداخلية للدولة العثمانية وكسب أراضي عثمانية لمد إمبراطوريتها إلى المياه الدافئة في البحر المتوسط , ولهذا عملت على تقويض القوة العثمانية من الداخل بإثارة الطموحات القومية لدى رعايا المسيحيين للباب العالي:السلاف في البلقان , والأرمن في الأناضول وغيرهم من الاقليات . وقد شهدت العلاقات الدولية في النصف الثاني من القرن التاسع عشر تنافس سياسي واقتصادي ودبلوماسي، لاقتسام املاك الدولة العثمانية، وسعت روسيا الى أضعاف الدولة العثمانية، وتقسيم ممتلكاتها، وتوسيع النفوذ الروسي في شواطئ البحر الاسود بالطرق الدبلوماسية والحروب العديدة التي خاضتها لتحقيق ذلك. لكن قضت معاهدة برلين على إنتصارات روسيا في حربها مع الدولة العثمانية ،و وضعت معاهدة برلين حداً لبطش روسيا وأدى إلى خيبة أمل روسية بألمانيا التي كانت تتوقع من الأخيرة الوقوف إلى جانبها في تلك المعاهدة , فنتج عن ذلك سوء العلاقة الروسية الألمانية وتوترها , وهكذا عدت معاهدة برلين العامل الرئيس للعداء الروسي الألماني والذي كان أحد الأسباب لإندلاع الحرب العالمية الأولى 1914 فيما بعد، وبالمقابل إنقلبت الدولة العثمانية من مصاف الدول العظمى المتبوعة إلى مصاف الدولة التابعة وقد إنهارت فيها دعائم المقاومة للأخطار الداخلية والخارجية التي تواجهها . بلغت الدولة العثمانية ذروة مجدها وقوتها خلال القرنين الساس عشر والسابع عشر , ودَبَ في القرون اللاحقة الضعف وكثرت الثورات وتدخُل الدول العظمى في شؤون الدولة أدى إلى إنهاكها , ولم تنتهِ الكوارث بإبرام معاهدة برلين فقد توالت عليها الأزمات التي أثارتها تلك الدول للقضاء على ماتبقى لها من ممتلكات ونفوذ. وإذا كان المرء يبحث عن سبب جذري لـ "الحرب العالمية الأولى"، فيجب اعتبار مؤتمر برلين لعام 1878 أحد أهم الأسباب لحرب عام 1914. فلابد من دراسة مؤتمر برلين بعناية باعتباره نقطة تحول حقيقية في التاريخ الدبلوماسي الأوروبي.
التجاوزات على الحصص المائية في أعلى سد حمرين
Authors: سعدون محمد أ.م.د. رشيد , جاسم حمادي م.د. محمد 
Published: February 2023

تعد مشكلة التجاوز على الحصص المائية من المشكلات الأزلية والتي باتت في الكثير منها تمثل حقاً مكتسباً للمتجاوزين بسبب قدم هذا التجاوز .
ويعد التجاوز في اعلى سد حمرين من المشكلات التي يصعب حلها كونها تقع في منطقة جغرافية معقدة فهي جزء من المنطقة المتموجة من العراق فضلاً عن صعوبة التنقل فيها بسبب كثرة الاودية ناهيك عن كون مناطقها ضمن اقليم كردستان أو ضمن المناطق المتنازع عليها بين المركز والاقليم والتي اصبحت تستهلك كميات كبيرة من نهر ديالى تتجاوز الــ (38) متر مكعب بالثانية ومن هذه المشاريع هي مشروع شيخ لنكر , مشروع قره بلاغ , مشروع ري قرتبه , مشروع ري السلام , مشروع كشكول , مشروع بلاجو . مشروع محنة اباد , مشروع الدكات وجدول السعدية وغيرها من المشاريع الصغيرة, علماً ان هذه المشاريع تأخذ المياه مباشرةً من النهر فهي في الغالب غير مبوبة وبالتالي ادى إلى ضرر كبير على محافظة ديالى تمثلت في هلاك الكثير من بساتينها وهجرة الفلاحين لأراضيها فضلاً عن ذلك صعوبة توفير مياه الشرب لسكان المحافظة وخصوصاً في السنوات الشحيحة.
Influence of additional filters on radiation dose during chest radiography.
Authors: Al-Murshedi Sadeq , Mohammed Ali Ali 
Published: February 2023

The goal of this study was to examine the impact of using additional aluminum (Al) and copper (Cu) filters on radiation dose during the adult chest x-ray examination. Adult chest phantoms without and with different slabs of animal fat were used for simulating underweight, overweight, and obese patients, respectively. Phantoms were examined without and with various levels of extra Al and Cu filtering over a range of exposure parameters. A dose area product (DAP) meter was used to measure the radiation dose. Results demonstrated that radiation doses were significantly reduced (p=0.001) when applying extra filters compared with no filters for all of the different phantom sizes. The highest reduction in radiation dosage was 38, 41, and 42 percent for underweight, overweight, and obese phantom size, respectively, by 1mm Al+0.2mm Cu. In conclusion, the use of extra filters in chest x-ray imaging provides an optimal dose reduction choice regardless of the thickness of the chest region to be radiographed.

DOI: http://dx.doi.org/10.31257/2018/JKP/2022/140206
Impact of COVID-19 on Kazakhstan’s economy
Authors: Kenzhin Zh.B. , Sultanova M.B. , Aidaralieva A.A. , Mukina G.S. , Eniola A.A. 
Published: February 2023

Object: This article aims to analyze the impact of the COVID-19 outbreak on the economy of Kazakhstan, identify positive and negative factors, and propose recommendations for further economic development and overcoming the crisis based on the opinions of leading experts in the field.Methods: A theoretical review of the scientific literature on the research topic.Results: Using scientific analysis based on publications dated 2020-2021 and statistical data from official information resources, the main directions of Kazakhstan’s economic development were outlined. The analysis of the situation in the sphere of economic research was carried out. Economic freedom indicator and business climate ranking were provided.Conclusions: Since assessment and prediction of the economic situation in Kazakhstan have been performed in accordance with various criteria and methods, it is therefore difficult to obtain an unambiguous picture of socioeconomic threats induced by the processes taking place in the global economy nowadays. Nevertheless, the analysis of economic indicators shows that the economic well-being of the country appears to be satisfactory, and Kazakhstan has good prospects for further development in many areas. New approaches to the investment sector in the economic policy of the country are necessary to overcome the crisis caused by the pandemic. The authors propose a change in the basic approaches to regulatory policy, formulated the principles of comprehensive and effective regulation, taking into account current economic challenges.
The Recovery of Ukraine
Authors: Heyets Valeriy , Blyzniuk Viktoriia , Nykyforuk Olena 
Published: February 2023

Abstract
Ukraine is currently facing enormous humanitarian challenges as a result of the ongoing aggression of the Russian government and its military and financial establishment. This article discusses essential aspects of the societal impacts of this aggression. Our attention is focused on the recovery of the socioeconomic and financial sphere and of human potential. Emphasis is placed on the expediency of Ukraine's implementation of a social quality-based management approach after the end of the war. This may help politicians and citizens to rethink and reconstruct Ukrainian society on the basis of socioeconomic security, social cohesion, social inclusion, and guaranteed societal opportunities, rooted in the societal values of equality and solidarity, social justice, human dignity, and eco-equilibrium. We argue that introducing the concept of social quality, adapted to domestic conditions, into the public administration system of postwar Ukraine would contribute to rethinking the “social contract” so as to gradually find a reasonable balance between two priorities: the simultaneous increase of efforts to systematically eliminate the threats of external aggression and the accelerated restoration of the national socioeconomic space on principles of sustainable, inclusive development.
Postradiosurgery cystic degeneration in brain metastases causing delayed and potentially severe sequelae: systematic review and illustrative cases
Authors: Giantini-Larsen Alexandra , Abou-Mrad Zaki , Goldberg Jacob L. , El Ahmadieh Tarek Y. , Beal Kathryn , Young Robert J. , Rosenblum Marc , Moss Nelson S. 
Published: February 2023

BACKGROUND
Cystic postradiation degeneration has previously been described in the literature as a rare but potentially severe complication after central nervous system (CNS) irradiation for vascular malformations. Limited cases have been reported in the setting of brain metastases.

OBSERVATIONS
Thirty-six total cases, including three reported here, of cystic postradiation degeneration are identified. Of 35 cases with complete clinical information, 34 (97.25%) of 35 were symptomatic from cystic changes at diagnosis. The average time between initial radiation dose and cyst development was 7.61 years (range 2–31 years). Although most patients were initially treated conservatively with medication, including steroids, 32 (88.9%) of 36 ultimately required surgical intervention. The most common interventions were craniotomy for cyst fenestration or resection (25 of 36; 69.4%) and Ommaya placement (8 of 36). After intervention, clinical improvement was seen in 10 (67%) of 15 cases, with persistent or worsening deficit or death seen in 5 (33%) of 15. Cysts were decompressed or obliterated on postoperative imaging in 20 (83.3%) of 24 cases, and recurrence was seen in 4 (16.7%) of 24.

LESSONS
Cystic degeneration is a rare and delayed sequela after radiation for brain metastases. This entity has the potential to cause significant and permanent neurological deficit if not properly recognized and addressed. Durable control can be achieved with a variety of surgical treatments, including cyst fenestration and Ommaya placement.
Structural Performance of Topologically Interlocked Flat Vaults According to Joint Details
Authors: Kurucu Aybala Tuba , İlerisoy Zeynep Yeşim 
Published: February 2023

Although the notion of topological interlocking (TI) is not new, today's environment of parametric design tools encourages architects and engineers to reconsider the potential of TI systems and alternative geometries for TI blocks. This paper aims to generate alternatives for TI blocks by increasing the contact surface area of interlocking using X-joints to demonstrate the relationship between contact surface incrementation and structural performance of slab-like TI assemblies. A case study is presented in which two flat vaults with dimensions of 50 × 50 cm were designed using truncated octahedra and a new geometry based on X-joints added to the truncated octahedra. Each flat vault was subjected to a finite element analysis using SimScale to compare structural performances using displacement and von Mises stress maps. According to the findings, there was a 74.7% improvement in displacement and 76.8% reduction in von Mises stresses. Another analysis was conducted over a seven-element system by applying force to the centre element to measure the results on a single element. Results indicated a 41.7% improvement in displacement and a 39% reduction in von Mises stresses. The improved structural performance was demonstrated through these two-stage evaluations.
Cerium oxide nanoparticles protect against chondrocytes and cartilage explants from oxidative stress via Nrf2/HO-1 pathway in temporomandibular joint osteoarthritis
Authors: Xiong Liping , Bao Han , Li Size , Gu Deao , Li Yuyang , Yin Qianwen , Li Wen , Miao Leiying , Liu Chao 
Published: February 2023

Graphical AbstractIn TMJ-OA, CNPs could effectively remove ROS in chondrocytes by activating the Nrf2/HO-1 signaling pathway and exert excellent antioxidant and anti-inflammatory effects.
Essential oils of Psidium cattleianum Sabine leaves and flowers: Anti-inflammatory and cytotoxic activities
Authors: Elsayed Heba E. , El-Deeb Eman M. , Taha Heba , Taha Hussein S. , Elgindi Mohamed R. , Moharram Fatma A. 
Published: February 2023

Introduction:Psidium cattleianum Sabine is a Brazilian native shrub cultivated for its edible fruit araçá (strawberry guava). P. cattleianum is recognized for health and food applications, although the essential oils (EOs) from the Egyptian inhabitant are not fully explored. The current study investigated the anti-inflammatory and cytotoxic activities of EOs from P. cattleianum leaves and flowers.Materials and methods: The EOs were obtained by three different methods viz; the conventional hydro-distillation, microwave assisted hydro-distillation, and supercritical fluid extraction, while their analysis was accomplished using GC/MS. The derived EOs were screened for their anti-inflammatory activity in the 5-lipoxygenase, COX-1, and COX-2 enzyme based assays, while the anticancer potential was deduced from MTT cytotoxic assay, cell cycle, and western blotting analysis.Results and discussion: Among other methods, supercritical fluid extraction offered the highest EO yield, 0.62% (leaves) and 1.4% (flowers). GC/MS identified β-caryophyllene and α-humulene in both organs with high but variable percentages. The leaves demonstrated strong activity in inhibiting the 5-lipoxygenase enzyme (IC50 2.38), while the flowers, in inhibiting COX-2 (IC50 2.575). Moreover, the leaves showed potent, selective cytotoxicity to MCF-7 cells (IC50 5.32) via apoptosis by modulating the p53/Bax/Bcl2 axis. The deduced activities are possible due to the synergism between the volatile components that endorses P. cattleianum leaves’ EOs in the management of breast cancer and inflammatory disorders.
Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation
Authors: Venturini Gabriela , Alvim Juliana M. , Padilha Kallyandra , Toepfer Christopher N. , Gorham Joshua M. , Wasson Lauren K. , Biagi Diogo , Schenkman Sergio , Carvalho Valdemir M. , Salgueiro Jessica S. , Cardozo Karina H. M. , Krieger Jose E. , Pereira Alexandre C. , Seidman Jonathan G. , Seidman Christine E. 
Published: February 2023

IntroductionChagas cardiomyopathy, a disease caused by Trypanosoma cruzi (T. cruzi) infection, is a major contributor to heart failure in Latin America. There are significant gaps in our understanding of the mechanism for infection of human cardiomyocytes, the pathways activated during the acute phase of the disease, and the molecular changes that lead to the progression of cardiomyopathy.MethodsTo investigate the effects of T. cruzi on human cardiomyocytes during infection, we infected induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) with the parasite and analyzed cellular, molecular, and metabolic responses at 3 hours, 24 hours, and 48 hours post infection (hpi) using transcriptomics (RNAseq), proteomics (LC-MS), and metabolomics (GC-MS and Seahorse) analyses.ResultsAnalyses of multiomic data revealed that cardiomyocyte infection caused a rapid increase in genes and proteins related to activation innate and adaptive immune systems and pathways, including alpha and gamma interferons, HIF-1α signaling, and glycolysis. These responses resemble prototypic responses observed in pathogen-activated immune cells. Infection also caused an activation of glycolysis that was dependent on HIF-1α signaling. Using gene editing and pharmacological inhibitors, we found that T. cruzi uptake was mediated in part by the glucose-facilitated transporter GLUT4 and that the attenuation of glycolysis, HIF-1α activation, or GLUT4 expression decreased T. cruzi infection. In contrast, pre-activation of pro-inflammatory immune responses with LPS resulted in increased infection rates.ConclusionThese findings suggest that T. cruzi exploits a HIF-1α-dependent, cardiomyocyte-intrinsic stress-response activation of glycolysis to promote intracellular infection and replication. These chronic immuno-metabolic responses by cardiomyocytes promote dysfunction, cell death, and the emergence of cardiomyopathy.
Computationally-feasible uncertainty quantification in model-based landslide risk assessment
Authors: Yildiz Anil , Zhao Hu , Kowalski Julia 
Published: February 2023

Introduction: Increasing complexity and capacity of computational physics-based landslide run-out modelling yielded highly efficient model-based decision support tools, e.g. landslide susceptibility or run-out maps, or geohazard risk assessments. A reliable, robust and reproducible development of such tools requires a thorough quantification of uncertainties, which are present in every step of computational workflow from input data, such as topography or release zone, to modelling framework used, e.g. numerical error.Methodology: Well-established methods from reliability analysis such as Point Estimate Method (PEM) or Monte Carlo Simulations (MCS) can be used to investigate the uncertainty of model outputs. While PEM requires less computational resources, it does not capture all the details of the uncertain output. MCS tackles this problem, but creates a computational bottleneck. A comparative study is presented herein by conducting multiple forward simulations of landslide run-out for a synthetic and a real-world test case, which are used to construct Gaussian process emulators as a surrogate model to facilitate high-throughput tasks.Results: It was demonstrated that PEM and MCS provide similar expectancies, while the variance and skewness differ, in terms of post-processed scalar outputs, such as impact area or a point-wise flow height. Spatial distribution of the flow height was clearly affected by the choice of method used in uncertainty quantification.Discussion: If only expectancies are to be assessed then one can work with computationally-cheap PEM, yet MCS has to be used when higher order moments are needed. In that case physics-based machine learning techniques, such as Gaussian process emulation, provide strategies to tackle the computational bottleneck. It can be further suggested that computational-feasibility of MCS used in landslide risk assessment can be significantly improved by using surrogate modelling. It should also be noted that the gain in compute time by using Gaussian process emulation critically depends on the computational effort needed to produce the training dataset for emulation by conducting simulations.