bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compartmental tongue surgery for intermediate‐advanced squamous cell carcinoma: A multicentric study
Authors: Calabrese Luca , Tagliabue Marta , Grammatica Alberto , De Berardinis Rita , Corso Federica , Gazzini Luca , Abousiam Monir , Fazio Enrico , Mattavelli Davide , Fontanella Walter , Giannini Lorenzo , Bresciani Lorenzo , Bruschini Roberto , Gandini Sara , Piazza Cesare , Ansarin Mohssen 
Published: September 2023

AbstractBackgroundA multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).MethodsWe studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.ResultsIn the CTS group, survival and prognosis were significantly associated with positive lymph‐nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T‐N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause‐Specific Survival (CSS) of 3.24 (95% CI: 1.71–6.11; p < 0.001); HR Loco‐Regional Recurrence Free Survival (LRRFS) of 2.54 (95% CI: 1.47–4.40; p < 0.001); HR Overall Survival (OS) of 0.11 (95% CI: 0.01–0.77; p = 0.03).ConclusionPerforming the CTS could provide better CSS and LRRFS than SWMS regardless of the center performing the surgery, in advanced OTSSC.
Magnitude and predisposing factors of intestinal parasitosis and tuberculosis coinfection at five health institutions in Southern Ethiopia: A cross‐sectional study
Authors: Shibabaw Agumas , Tilahun Mihret , Gedefie Alemu , Sahle Zenawork , Belete Melaku A. , Ebrahim Hussen , Debash Habtu , Sharew Bekele 
Published: September 2023

AbstractBackground and AimsIntestinal parasites affect the tuberculosis disease outcome by shifting the cell‐mediated to humoral immune response and host immune system suppression. However, Mycobacterium tuberculosis (MTB) infection favors the immune escape of parasites. Hence, exploring the rate of intestinal parasitic coinfection with pulmonary tuberculosis (PTB) and its predisposing factors to take better preventive, control, and management measures.MethodsA facility‐based cross‐sectional study was conducted from September to December 2020 at five health institutions in Hawassa city. A total of 214 PTB patients were diagnosed using the GeneXpert assay and enrolled in this study. Demographic, clinical, and risk factors data were collected using a structured questionnaire. Stool samples were collected using a clean, labeled, and leak‐proof stool cup. Stool samples were examined using direct saline microscopy and the formal‐ether concentration technique. The data were entered and coded in SPSS software for analysis. Bivariate and multivariate logistic regression were employed to identify the associated risk factors. A p‐value less than  0.05 was considered statistically significant.ResultsThe overall rate of intestinal parasitic‐MTB coinfection was 36.9%. The most dominant intestinal parasite was Gardia lamblia (17.8%, 38), followed by Entamoeba histolytica/dispar (9.3%, 20). Intestinal parasitosis coinfection of PTB was associated with being rural resident (adjusted odds ratio [AOR] = 2.42; 95% confidence interval [CI]: 1.23–4.8), not washing of fruits and vegetables before eating [AOR = 4.14; 95% CI: 1.92–9], being at the early stage of anti‐TB treatment [AOR = 3; 95% CI: 1.5–6.3] and presence of chronic diseases [AOR = 7; 95% CI: 3.4–14].ConclusionThe burden of intestinal parasites‐MTB coinfection was high. Those who wash fruits and vegetables before eating should be encouraged, early treatment of PTB patients and avoiding the practice of open‐field defecation, especially in rural communities, is necessary. The dual effect of coinfection on disease severity and treatment success needs further cohort study.
Characteristics of carpal tunnel syndrome in patients with cervical radiculopathy: A cross‐sectional study
Authors: Teymouri Alireza , Emami Razavi Seyede Zahra , Azadvari Mohaddeseh , Hosseini Maryam 
Published: September 2023

AbstractBackground and AimsCervical radiculopathy (CR) is a group of signs and symptoms caused by cervical root dysfunction. Patients with this condition may also have carpal tunnel syndrome (CTS), which is caused by compression of the median nerve in the carpal tunnel. This coexistent condition is referred to as double crush syndrome (DCS) which is explained by proximal disruption in axoplasmic flow that may result in nerve dysfunction. Yet, the accuracy of this hypothesis remains controversial.Materials and MethodsPatients with confirmed CR according to electromyography were included in this retrospective study. However, we omitted patients with overt diabetic neuropathy, prior spinal or hand surgery and/or fractures, and rheumatoid arthritis. Patients underwent electrodiagnostic studies, and the results were used to determine CTS severity. We used Pearson's χ2 test to assess the correlation between the severity of CTS and CR. Descriptive analysis was used to report patient characteristics and the prevalence of CTS in CR patients.ResultsWe included 291 participants, 59% of whom were women. Although insignificant, DCS was observed more in women (n = 110) compared to men (n = 71). However, we found that patients with DCS (54.81 ± 13.3) were older than non‐DCS patients (43.71 ± 12.94) which was statistically significant (p < 0.05). There was statistically no correlation between the severity of CR and CTS, ipsilaterlly (p > 0.05). In total, CTS was observed in 62.2% (n = 181) patients.ConclusionIn summary, we found a relatively high prevalence of DCS in the present study. In patients with and without DCS, gender did not seem to play a role but the growing age seemed to contribute to DCS. The severity of CTS was not related to CR severity at any cervical level, which negates a causal relation between the pre‐existing CR and newly diagnosed CTS.
Assessment of changes in severity of compound drought and saltwater intrusion events based on a multi‐index approach in Pearl River estuary
Authors: Li Dan , Liu Bingjun , Lu Yang , Fu Jianyu 
Published: September 2023

AbstractGlobal warming alters the inherent variability of climate variables and induces more frequent extremes of hydroclimatic compound events with substantial impacts. The concurrence of hydrological drought and saltwater intrusion in the estuary can have devastating effects on agricultural production, water security, and ecological health. In this study, the compound drought and saltwater intrusion extreme indices, including the Blend Drought and Saltwater intrusion Index (BDSI), the Compound drought and Saltwater intrusion Index (CDSI) and the Standardized Drought and Saltwater intrusion Index (SDSI), were constructed to monitor compound extremes in the critical zone of Pearl River Estuary during the dry season from 1999 to 2016. The results reveal that the three compound indices can effectively depict different aspects of compound drought and saltwater intrusion extreme events in the critical zone of Pearl River Estuary. Among the three indices, the SDSI performed best in depicting compound drought‐saltwater intrusion events, while the BDSI outperformed the other indices in depicting high value of Standardized Runoff Index (SRI) and Standardized Saltwater intrusion Index (SSI), and the CDSI outperformed the other indices in depicting low values of SRI and SSI. Using those developed compound indices, we found that the frequency of abnormal and moderate compound drought‐saltwater intrusion events increased from 9.26% to 12.03% during the period of 1999–2016, while severe, extreme and exceptional compound drought‐saltwater intrusion events were rare.
The relationship between dietary inflammatory index values and thyroid function in the US adult population: An analysis of the NHANES 2007–2012 cohort
Authors: Wang Mingzheng , Lu Xiaofeng , Zheng Xiaogang , Liu Junru 
Published: September 2023

AbstractObjectiveResearchers have developed the Dietary Inflammatory Index (DII) as a tool to quantify the inflammatory potential of a given diet. Higher DII scores indicated a more proinflammatory diet. While inflammation is known to have a strong impact on thyroid function, the precise nature of the association between DII scores and thyroid function has yet to be clarified. This study was conducted with the goal of exploring this relationship in a representative population of adults from the United States.MethodsFor this study, we used data from the National Health and Nutrition Examination Survey (NHANES). Standardized questionnaires were used to collect demographic and dietary data from the participants, and laboratory tests were used to collect data on the participants' thyroid parameters and other relevant data. Linear regression models and smoothed curve fitting were used to assess the relationship between DII scores and thyroid function, with weighted data analyses and subgroup analyses being conducted as appropriate.ResultsIn total, 7712 subjects were recruited from the NHANES 2007–2012 cohort. Their weighted mean age was 44.87 (0.47) years, mean DII score was 1.41 (0.05). Mean FT3 was 3.20 (0.01) pg/mL and mean TT4 was 7.81 (0.03) µg/dL. In adjusted analyses, higher DII values were related to increases in FT3 (β = .007; p = .027) and TT4 (β = .050; p = .005) levels. Subgroup analyses showed a negative correlation between FT3 levels and DII scores in a population with high urinary iodine concentrations.ConclusionThese data indicate that the consumption of a more proinflammatory diet, as evidenced by elevated DII scores, is correlated with significant increases in FT3 and TT4 levels. However, for people with high urinary iodine concentrations, a more proinflammatory diet was associated with lower FT3 levels. Additional research will be vital to clarify the mechanistic basis for these findings.
KDM2B regulates inflammation and oxidative stress of sepsis via targeting NF‐κB and AP‐1 pathways
Authors: Li Xin , Tian Xinyu , Zhang Dongliang 
Published: September 2023

AbstractBackgroundsThe kidney is an easily affected organ with sepsis which is a main underlying cause of acute kidney injury (AKI). Histone‐modifying lysine‐specific demethylase 2B (KDM2B) is involved in numerous pathological processes, such as cell senescence and tumor development. However, the role of KDM2B in sepsis‐induced AKI is unclear.ObjectsTo investigate the role of KDM2B on cell viability, inflammation and oxidative stress of sepsis‐associated AKI, and the involved signaling pathways.MethodsAn AKI model in vitro was established through lipopolysaccharide (LPS)‐induction in HK‐2 cells. Western blots were performed to evaluate the expression of KDM2B, cyclooxygenase 2 (COX2), inducible nitric oxide synthase (iNOS), p65, c‐Jun and c‐Fos, as well as p65 phosphorylation. Cell viability was measured using CCK‐8 kit. ELISA was performed to analyze the production of layered double hydroxide (LDH), tumor necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐18, vascular cell adhesion molecule‐1 (VCAM‐1), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), and H2O2. The qPCR was used to evaluate the transcription level of TNF‐α, IL‐1β, IL‐18, and VCAM‐1.ResultsKDM2B knockdown alleviated LPS‐induced cytotoxicity, decreased LDH release, and improved cell viability. KDM2B knockdown reduced concentration of inflammation‐related molecules including TNF‐α, IL‐1β, IL‐18, and VCAM‐1, and inhibited their transcription. Moreover, KDM2B knockdown promoted the quantity of SOD and GSH, while declined the production of MDA, H2O2, COX2, and iNOS. Further, KDM2B played a role in LPS‐induced HK‐2 cell injury by activating nuclear factor κB (NF‐κB) and activator protein 1 (AP‐1) pathways.ConclusionKDM2B knockdown reduced cytotoxicity, inflammation and oxidative stress in LPS‐induced AKI via inhibiting NF‐κB and AP‐1 pathways, indicating KDM2B may be a promising therapeutic target for the treatment of sepsis‐associated AKI.
Evaluating interactions of polygenic risk scores and NAT2 genotypes with tobacco smoking in bladder cancer risk
Authors: Pradhan Pranoti , Jia Guochong , Khankari Nikhil K. , Zheng Wei 
Published: September 2023

AbstractTobacco smoking is the most important risk factor for bladder cancer. Previous studies have identified the N‐acetyltransferase (NAT2) gene in association with bladder cancer risk. The NAT2 gene encodes an enzyme that metabolizes aromatic amines, carcinogens commonly found in tobacco smoke. In our study, we evaluated potential interactions of tobacco smoking with NAT2 genotypes and polygenic risk score (PRS) for bladder cancer, using data from the UK Biobank, a large prospective cohort study. We used Cox proportional hazards models to measure the strength of the association. The PRS was derived using genetic risk variants identified by genome‐wide association studies for bladder cancer. With an average of 10.1 years of follow‐up of 390 678 eligible participants of European descent, 769 incident bladder cancer cases were identified. Current smokers with a PRS in the highest tertile had a higher risk of developing bladder cancer (HR: 6.45, 95% CI: 4.51‐9.24) than current smokers with a PRS in the lowest tertile (HR: 2.41, 95% CI: 1.52‐3.84; P for additive interaction = <.001). A similar interaction was found for genetically predicted metabolizing NAT2 phenotype and tobacco smoking where current smokers with the slow NAT2 phenotype had an increased risk of developing bladder cancer (HR: 5.70, 95% CI: 2.64‐12.30) than current smokers with the fast NAT2 phenotype (HR: 3.61, 95% CI: 1.14‐11.37; P for additive interaction = .100). Our study provides support for considering both genetic and lifestyle risk factors in developing prevention measures for bladder cancer.
Spontaneously hatching human blastocyst is associated with high development potential and live birth rate in vitrified‐warmed single blastocyst transfer: A retrospective cohort study
Authors: Han E Jung , Park Jae Kyun , Eum Jin Hee , Bang Soyoung , Kim Ji Won , Lee Woo Sik 
Published: September 2023

AbstractObjectiveTo investigate the effect of hatching status on predicting pregnancy outcomes in single vitrified‐warmed blastocyst transfer (SVBT) by objectively subdividing pre‐implantation blastocysts according to hatching status.MethodsThis retrospective study included 817 SVBT cycles performed between January 2016 and December 2017. Transferred embryos were categorized according to their hatching status as follows: group I (n = 147), non‐hatching blastocysts; group II (n = 484), hatching blastocysts; and group III (n = 186), completely hatched blastocysts. Hatching blastocysts (group II) were then classified based on the ratio of the blastocystic diameter outside and inside the zona pellucida into early (n = 185), mid‐ (n = 103), and late (n = 196) hatching stages. Implantation rate (IR), clinical pregnancy rate (CPR), live birth rate (LBR), multiple pregnancy rate (MPR), miscarriage rate, and neonatal outcomes were evaluated.ResultsFor groups I, II, and III, respectively, the results were as follows: IR (28.6%, 43.6%, and 53.8%; P < 0.001), CPR (27.9%, 42.8%, and 53.2%; P < 0.001), and LBR (23.1%, 32.0%, and 42.5%; P < 0.001). Group III had better IR, CPR, and LBR. Among hatching blastocysts, late‐hatching blastocysts had the highest IR (33.5%, 46.6%, and 51.5% for early, mid‐, and late hatching, respectively; P = 0.002) and CPR (33.0%, 45.6%, and 50.5%; P = 0.002), with a tendency for a higher rate of LBR. Neonatal outcomes were not influenced by the hatching status.ConclusionAdvanced hatching status is positively associated with a higher rate of clinical pregnancy and live birth with no negative effects on neonatal outcomes. Additionally, the quantitative classification of hatching status was found to be predictive of pregnancy outcomes.
Research procedure acceptability through women during pregnancy and postpartum: A pilot study
Authors: Simon Julien , Thisse Jeanne , Chabert Camille , Barasinski Chloé , Ambroise Grandjean Gaëlle 
Published: September 2023

AbstractObjectiveTo assess the feasibility and relevancy of a systematic data collection process in characterizing factors influencing research acceptability through women during pregnancy and early postpartum.MethodsA pilot prospective observational crossover unicentric study was conducted in Est France. All the women (except language barrier and intensive care transfer) were called upon to complete a survey (33 questions). The primary endpoints were the participation rate and the completeness of the information. The secondary endpoint was the participants' sociodemographic background and preferences regarding research (bivariate analysis, P value <0.20).ResultsWithin the research period (February 23–March 8, 114 childbirths), 105 women fitting the criteria were called upon for the survey. The participation rate and completeness were high. The participation rate was 93% with six lost to follow‐up, and one refusal. The global filling rate was 95%. We highlighted two plausible variables of interests for research participation: women age older (P value 0.119) and level of education (P value 0.176). A sufficient cooling‐off period, the commitment of women's health providers, and the possibility to accede research results might favor women's involvement. Acceptability would appear to be decreasing when the protocol implied fetal or neonatal data collection (compared to maternal data), unless research led to a better therapeutic option.ConclusionThe data collection process is highly feasible and provide consistent data. Larger‐scale output obtention should enhance the conception and rollout of projects, first by calculating sample size based on potentials for recruitments adjusted to populations, characteristics and second by fitting the experimental design to women's expectations.
The impact of a previous cesarean section on the risk of perioperative and postoperative complications during vaginal hysterectomy
Authors: Weiss Moran , Baumfeld Yael , Rotem Reut , Gedalia Yuval , Erenberg Miriam , Weintraub Adi Y. 
Published: September 2023

AbstractObjectiveTo investigate whether a previous cesarean section increases the risk of perioperative and postoperative complications during vaginal hysterectomy.MethodsA retrospective cohort study of women who had undergone a vaginal hysterectomy for benign indications between 2014 and 2019 was conducted, comparing patients with or without a previous cesarean section. Perioperative and postoperative complications during vaginal hysterectomy were assessed according to the Clavien‐Dindo classification system within 30 days of surgery. Duration of surgery, estimated blood loss, and postoperative hospitalization days were also recorded. A two‐sided P value of less than 0.05 was considered significant.ResultsA total of 185 women were included, 25 (13.5%) patients had undergone a previous cesarean section (study group) and 160 (86.5%) had no history of cesarean section (comparison group). We found no significant differences in demographic and clinical characteristics as well as postoperative complications and interventions, duration of surgery, estimated blood loss, and postoperative hospitalization days (P > 0.05). However, patients who underwent two or more cesarean sections had a significantly (P = 0.01) higher rate and grade of complications during vaginal hysterectomy, compared with women with only one previous cesarean section. All women who underwent two or more cesarean sections had mild complications during vaginal hysterectomy (40% grade I and 60% grade II, P = 0.01).ConclusionVaginal hysterectomy is a safe procedure with few severe complications, regardless of a previous cesarean section. More than one previous cesarean section may increase the risk of minor complications during a vaginal hysterectomy. Patients who underwent a previous cesarean section could be reassured that they do not face an increased risk of complications during a vaginal hysterectomy.
Successful embolization of subcutaneous mesenteric varices within an ileal conduit in a patient with liver cirrhosis
Authors: Sakurai Ayaka , Ohtsu Akira , Arai Seiji , Aoki Masanori , Ikeya Miho , Tokue Hiroyuki , Hori Keisuke , Fujizuka Yuji , Sekine Yoshitaka , Koike Hidekazu , Suzuki Kazuhiro 
Published: September 2023

IntroductionVenous hemorrhage from ectopic varices is potentially fatal. This report describes a rare case in which bleeding from mesenteric varices in an ileal conduit was treated successfully by embolization therapy.Case presentationThe patient was an 82‐year‐old man who had previously undergone total pelvic exenteration for colon cancer with creation of an ileal conduit for urinary diversion. He subsequently developed liver cirrhosis and underwent partial hepatectomy for hepatocellular carcinoma. 9 years after his colon surgery, he was admitted with gross hematuria. Computed tomography revealed subcutaneous mesenteric varices in the ileal conduit and hemorrhage as a result of rupture of the varices. The bleeding continued despite repeated manual compression but was eventually stopped by embolization therapy.ConclusionEmbolization therapy may be helpful for hemostasis in the event of intractable bleeding from mesenteric varices in an ileal conduit.
High‐performance piezoresistive sensors based on transfer‐free large‐area PdSe2 films for human motion and health care monitoring
Authors: Zhang Rui , Lin Jie , He Tao , Wu Jiafang , Yang Zhuojun , Liu Liwen , Wen Shaofeng , Gong Yimin , Lv Haifeng , Zhang Jing , Yin Yi , Li Fangjia , Lan Changyong , Li Chun 
Published: September 2023

AbstractTwo‐dimensional transition metal dichalcogenides (TMDs) are needed in high‐performance piezoresistive sensors due to their strong strain‐induced bandgap modification and thereby large gauge factors. However, integrating a conventional high‐temperature chemical vapor deposition (CVD)‐grown TMD with a flexible substrate necessitates a transfer process that inevitably degrades the sensing properties of the TMDs and increases the overall fabrication complexity. We present a high‐performance piezoresistive strain sensor that employs large‐area PdSe2 films grown directly on polyimide (PI) substrates via plasma‐assisted selenization of a sputtered Pd film. The reliable strain transfer from the substrate to the PdSe2 film ensures an outstanding strain‐sensing capability of the sensor. Specifically, the sensors have a gauge factor of up to −315 ± 2.1, a response time under 25 ms, a detection limit of 8 × 10−6, and an exceptional stability of over 104 loading–unloading cycles. By attaching the sensors to the skin surface, we demonstrate their application for measuring physiological parameters in health care monitoring, including motion, voice, and arterial pulse vibration. Furthermore, using the PdSe2 film sensor combined with deep learning technology, we achieved intelligent recognition of artery temperature from arterial pulse signals with only a 2% difference between predicted and actual temperatures. The excellent sensing performance, together with the advantages of low‐temperature fabrication and simple device structure, make the PdSe2 film sensor promising for wearable electronics and health care sensing systems.image
Radiolabeled imaging agents for Alzheimer's disease
Authors: Wu Jiajun , Li Kexin , Yang Jie , Mao Meiting , Cheng Yan 
Published: September 2023

AbstractAlzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder with long preclinical and prodromal phases in older people. Molecular imaging is a promising approach for noninvasive in vivo identification and tracking pathophysiological changes. In particular, nuclear neuroimaging in AD has extended beyond traditional evaluation of brain perfusion and glucose metabolism, and has achieved substantial progress over the past 2 decades. To gain a comprehensive understanding of nuclear neuroimaging with different targets in the brain, this review provides an overview of the literature on the current status and recent progress of the development of radioligands for definitive and differential diagnosis of AD.