bluuebunny/crossref_metadata_2025_split huggingface dataset:
Change in diaphragmatic morphology in single-lung transplant recipients: a computed tomographic study
Authors: Touchon François , Bermudez Julien , Habert Paul , Bregeon Fabienne , Thomas Pascal Alexandre , Reynaud-Gaubert Martine , Coiffard Benjamin 
Published: September 2023

Introduction: The influence of lung disease on the diaphragm has been poorly studied. The study aimed to evaluate the diaphragm morphology (height and thickness) in single-lung transplantation (SLTx), using computed tomography (CT), by assessing the evolution of the hemidiaphragm of the transplanted and the native side.Methods: Patients who underwent single lung transplantation in our center (Marseille, France) between January 2009 and January 2022 were retrospectively included. Thoracic or abdominal CT scans performed before and the closest to and at least 3 months after the surgery were used to measure the diaphragm crus thickness and the diaphragm dome height.Results: 31 patients mainly transplanted for emphysema or pulmonary fibrosis were included. We demonstrated a significant increase in diaphragm crus thickness on the side of the transplanted lung, with an estimated difference of + 1.25 mm, p = &lt;0.001, at the level of the celiac artery, and + 0.90 mm, p &lt; 0.001, at the level of the L1 vertebra while no significant difference was observed on the side of the native lung. We showed a significant reduction in the diaphragm height after SLTx on the transplanted side (−1.20 cm, p = 0.05), while no change on the native side (+0.02 cm, p = 0.88).Conclusion: After a SLTx, diaphragmatic morphology significantly changed on the transplanted lung, while remaining altered on the native lung. These results highlights that an impaired lung may have a negative impact on its diaphragm. Replacement with a healthy lung can promote the recovery of the diaphragm to its anatomical morphology, reinforcing the close relationship between these two organs.
Determination of spinal tracer dispersion after intrathecal injection in a deformable CNS model
Authors: Ayansiji Ayankola O. , Gehrke Daniel S. , Baralle Bastien , Nozain Ariel , Singh Meenesh R. , Linninger Andreas A. 
Published: September 2023

Background: Traditionally, there is a widely held belief that drug dispersion after intrathecal (IT) delivery is confined locally near the injection site. We posit that high-volume infusions can overcome this perceived limitation of IT administration.Methods: To test our hypothesis, subject-specific deformable phantom models of the human central nervous system were manufactured so that tracer infusion could be realistically replicated in vitro over the entire physiological range of pulsating cerebrospinal fluid (CSF) amplitudes and frequencies. The distribution of IT injected tracers was studied systematically with high-speed optical methods to determine its dependence on injection parameters (infusion volume, flow rate, and catheter configurations) and natural CSF oscillations in a deformable model of the central nervous system (CNS).Results: Optical imaging analysis of high-volume infusion experiments showed that tracers spread quickly throughout the spinal subarachnoid space, reaching the cervical region in less than 10 min. The experimentally observed biodispersion is much slower than suggested by the Taylor–Aris dispersion theory. Our experiments indicate that micro-mixing patterns induced by oscillatory CSF flow around microanatomical features such as nerve roots significantly accelerate solute transport. Strong micro-mixing effects due to anatomical features in the spinal subarachnoid space were found to be active in intrathecal drug administration but were not considered in prior dispersion theories. Their omission explains why prior models developed in the engineering community are poor predictors for IT delivery.Conclusion: Our experiments support the feasibility of targeting large sections of the neuroaxis or brain utilizing high-volume IT injection protocols. The experimental tracer dispersion profiles acquired with an anatomically accurate, deformable, and closed in vitro human CNS analog informed a new predictive model of tracer dispersion as a function of physiological CSF pulsations and adjustable infusion parameters. The ability to predict spatiotemporal dispersion patterns is an essential prerequisite for exploring new indications of IT drug delivery that targets specific regions in the CNS or the brain.
Metabolomic and transcriptomic analyses of rice plant interaction with invasive weed Leptochloa chinensis
Authors: Zhang Liang , Chen Ke , Li Tianrui , Yuan Shuren , Li Chenyang , Bai Lianyang , Wang Lifeng 
Published: September 2023

IntroductionLeptochloa chinensis is an annual weed in paddy fields, which can engage in competition with rice, leading to a severe yield reduction. However, theunderlying mechanism governing this interaction remain unknown.MethodsIn this study, we investigated the mutual inhibition between rice and the weed undermono-culture and co-culture conditions. We found that the root exudates of both species played essential roles in mediating the mutual inhibition. Further metabolomic analysis identified a significant number of differential metabolites. These metabolites were predominantly enriched in the phenylpropanoid and flavonoid biosynthesis pathways in weed and rice. Transcriptomic analysis revealed that the differentially expressed genes responding to the interaction were also enriched in these pathways.ResultsPhenylpropanoid and flavonoid biosynthesis pathways are associated with allelopathy, indicating their pivotal role in the response of rice-weed mutual inhibition.DiscussionOur findings shed light on the conserved molecular responses of rice and L. chinensis during theirinteraction, provide evidence to dissect the mechanisms underlying the allelopathic interaction and offer potential strategies for weed management in rice paddies.
Predicting non-improvement of symptoms in daily mental healthcare practice using routinely collected patient-level data: a machine learning approach
Authors: Franken Katinka , ten Klooster Peter , Bohlmeijer Ernst , Westerhof Gerben , Kraiss Jannis 
Published: September 2023

ObjectivesAnxiety and mood disorders greatly affect the quality of life for individuals worldwide. A substantial proportion of patients do not sufficiently improve during evidence-based treatments in mental healthcare. It remains challenging to predict which patients will or will not benefit. Moreover, the limited research available on predictors of treatment outcomes comes from efficacy RCTs with strict selection criteria which may limit generalizability to a real-world context. The current study evaluates the performance of different machine learning (ML) models in predicting non-improvement in an observational sample of patients treated in routine specialized mental healthcare.MethodsIn the current longitudinal exploratory prediction study diagnosis-related, sociodemographic, clinical and routinely collected patient-reported quantitative outcome measures were acquired during treatment as usual of 755 patients with a primary anxiety, depressive, obsessive compulsive or trauma-related disorder in a specialized outpatient mental healthcare center. ML algorithms were trained to predict non-response (&lt; 0.5 standard deviation improvement) in symptomatic distress 6 months after baseline. Different models were trained, including models with and without early change scores in psychopathology and well-being and models with a trimmed set of predictor variables. Performance of trained models was evaluated in a hold-out sample (30%) as a proxy for unseen data.ResultsML models without early change scores performed poorly in predicting six-month non-response in the hold-out sample with Area Under the Curves (AUCs) &lt; 0.63. Including early change scores slightly improved the models’ performance (AUC range: 0.68–0.73). Computationally-intensive ML models did not significantly outperform logistic regression (AUC: 0.69). Reduced prediction models performed similar to the full prediction models in both the models without (AUC: 0.58–0.62 vs. 0.58–0.63) and models with early change scores (AUC: 0.69–0.73 vs. 0.68–0.71). Across different ML algorithms, early change scores in psychopathology and well-being consistently emerged as important predictors for non-improvement.ConclusionAccurately predicting treatment outcomes in a mental healthcare context remains challenging. While advanced ML algorithms offer flexibility, they showed limited additional value compared to traditional logistic regression in this study. The current study confirmed the importance of taking early change scores in both psychopathology and well-being into account for predicting longer-term outcomes in symptomatic distress.
Loop diuretics association with Alzheimer’s disease risk
Authors: Graber-Naidich Anna , Lee Justin , Younes Kyan , Greicius Michael D. , Le Guen Yann , He Zihuai 
Published: September 2023

Objectives: To investigate whether exposure history to two common loop diuretics, bumetanide and furosemide, affects the risk of developing Alzheimer’s disease (AD) after accounting for socioeconomic status and congestive heart failure.Methods: Individuals exposed to bumetanide or furosemide were identified in the Stanford University electronic health record using the de-identified Observational Medical Outcomes Partnership platform. We matched the AD case cohort to a control cohort (1:20 case:control) on gender, race, ethnicity, and hypertension, and controlled for variables that could potentially be collinear with bumetanide exposure and/or AD diagnosis. Among individuals older than 65 years, 5,839 AD cases and 116,103 matched controls were included. A total of 1,759 patients (54 cases and 1,705 controls) were exposed to bumetanide.Results: After adjusting for socioeconomic status and other confounders, the exposure of bumetanide and furosemide was significantly associated with reduced AD risk (respectively, bumetanide odds ratio [OR] = 0.23; 95% confidence interval [CI], 0.15–0.36; p = 4.0 × 10−11; furosemide OR = 0.42; 95% CI, 0.38–0.47; p &lt; 2.0 × 10−16).Discussion: Our study replicates in an independent sample that a history of bumetanide exposure is associated with reduced AD risk while also highlighting an association of the most common loop diuretic (furosemide) with reduced AD risk. These associations need to be additionally replicated, and the mechanism of action remains to be investigated.
Effects of wearable therapies on jump performance in sport horses
Authors: Schmidt Therese E. , Gleason Claire B. , Samaniego Mercedez R. , White Robin R. 
Published: September 2023

IntroductionFailure to properly prepare the equine athlete for exercise and support post-exercise recovery is a contributing factor to physical breakdown and lameness. Equine physiotherapy was not introduced until the early twentieth century and has since evolved to allow for wearable therapies such as therapeutic boots to be accessible to a broad spectrum of equestrians. The purpose of this study was to evaluate the effects of ceramic boots, boots combining vibration and cryotherapy, and boots containing tourmaline on the performance of sport horses during jumping as well as to examine changes in vital signs in response to treatment.MethodsEight healthy horses received the 3 therapeutic boot treatments or a control (no boot) in a Latin square experiment for a period of 5 days each. Horses performed approximately 10 min of exercise through a jump chute for the 5 consecutive days and jump performance parameters were recorded during each exercise session. Therapeutics were applied in the morning prior to exercise per the manufacturer’s recommendation and were removed only for exercise.Results and DiscussionIn a Bayesian network analysis, changes in vital signs (heart rate, respiration, and temperature) were driven by individual animal, rather than boot treatment. Jump performance was influenced by boot treatment, physiological measurements, and individual animal. Therapeutic boots were associated with changes in conditional probabilities of numerous performance outcomes. This study indicates the use of wearable therapies may result in improved performance outcomes of sport horses in jumping exercises.
Propose an automated exfoliation process of MoS2 with a universal mechanical setup
Authors: Kobayashi Takashi , Sato Chiaki , Dohi Tetsuji , Kiriya Daisuke 
Published: September 2023

Abstract
Automation is an engineering method of transforming process speed, reproducibility, and scalability from the corresponding manual process. This paper proposes a simple mechanical setup for automating the exfoliation process of two-dimensional materials constructed with simple commercial parts. Given the large shear force on the adhesive tapes, the tapes can be fixed on a mechanical bar, and the other side of the tape moves with exfoliation from the substrates. The exfoliation rate can be modulated from 2 cm min−1 to 0.014 cm min−1 in the setup. The developed mechanics are simple with various customizable parameters and make the exfoliation process scalable.
PENERAPAN TECHNOLOGY ACCEPTANCE MODEL TERHADAP PENERIMAAN PENGGUNA AKHIR E-LEARNING STMIK STIKOM BALI
Authors: Shandyastini Ni Made , Pradnyani Novianti Kadek Dwi 
Published: September 2023

E-learning allows students of STMIK STIKOM Bali to keep learning even though physically absent or unable to attend when the learning process going on in the classroom. The utilization of e-learning can also make the development a high learning flexibility. The perception of the user in this case is a student will be indispensable in order to assist the utilization of e-learning optimally. The goal of this research will examine about admissions in the utilization of e-learning used in STMIK STIKOM Bali. The behavior of students needed to know what the students felt towards e-learning. The research will be focused on reviewing the acceptance of the use of e-learning in accordance with the model of the Technology Acceptance Model (TAM). Analysis of the results obtained showed that the student respondents on this aspect of convenience and expediency of having a positive influence to the attitude when using e-learning, even on the final results of the e-learning has not been well received by the users (students). Whereas, on the usefullnes aspects of the lecturer, respondents have influence nearly all other aspects, so that the final result obtained is lecturer receives well the use of e-learning in the learning process. Further research can be developed by developing indicators for each variable. Keyword : TAM, e-learning, PLS
Analysis and Design of Work Systems using Hazard Analysis and Critical Control Points (HACCP) Standards at Mr. Sarbani’s Tempe Jombor Sukoharjo
Authors: Lestari Mathilda Sri , Prasetyo Rian , Hartanti Sri 
Published: September 2023

<p><strong>MSMEs </strong><strong>have very </strong><strong>large</strong><strong> number of actors so </strong><strong>they </strong><strong>play </strong><strong>an important role in </strong><strong>community</strong><strong> welfare</strong><strong>.</strong><strong> </strong><strong>One popular type of MSMEs is the food producer. This study focuses on UKM </strong><strong>Tempe Pak Sarbani </strong><strong> (UKMTS), who produces tempe, the traditional Indonesian food and is located in </strong><strong>Jombor Sukoharjo</strong><strong>.</strong><strong> </strong><strong>UKMTS </strong><strong>production process is directly related to the production environment because it affects the level of productivity, smoothness, and timeliness of production. The </strong><strong>tempe </strong><strong>production process</strong><strong>es</strong><strong> at </strong><strong>UKMTS are</strong><strong> still </strong><strong>manual</strong><strong>, and ha</strong><strong>ve</strong><strong> not met the </strong><strong>conditions </strong><strong>for the application of Good Processed Food Production Methods (CPP). </strong><strong>At UKMTS p</strong><strong>roduction </strong><strong>processes </strong><strong>do not </strong><strong>yet </strong><strong>meet standards and </strong><strong>have </strong><strong>irregular facility arrangements </strong><strong>which </strong><strong>greatly hinder operators in carrying out the production process. </strong><strong>Therefore i</strong><strong>t is necessary to improve the work system and design a repair work system based on HACCP principles </strong><strong>t</strong><strong>o meet HACCP standards for the </strong><strong>M</strong><strong>SME scale. </strong><strong>B</strong><strong>ased on all the discrepancies ob</strong><strong>served, currently t</strong><strong>he application of CPPB for </strong><strong>UKMTS </strong><strong>is at level 4. </strong><strong>At</strong><strong> this </strong><strong>level</strong><strong>, 9 critical control points are </strong><strong>indicat</strong><strong>ed which must be made critical,</strong><strong> </strong><strong>monitor</strong><strong>ed </strong><strong>and improve</strong><strong>d </strong><strong>to </strong><strong>avoid </strong><strong>dangers that </strong><strong>may </strong><strong>occur. In the last stage of implementing HACCP in UKM</strong><strong>TS</strong><strong>, a documentation system was created for the monitoring process.</strong></p><p><strong><em>Keywords</em></strong> – <em>HACCP, </em><em>P</em><em>roduction, </em><em>W</em><em>ork </em><em>S</em><em>ystem, MSME</em><em> (UKM).</em></p>
Directed retreat and navigational mechanisms in trail following Formica obscuripes
Authors: Freas Cody A. , Spetch Marcia L. 
Published: September 2023

AbstractAnt species exhibit behavioural commonalities when solving navigational challenges for successful orientation and to reach goal locations. These behaviours rely on a shared toolbox of navigational strategies that guide individuals under an array of motivational contexts. The mechanisms that support these behaviours, however, are tuned to each species’ habitat and ecology with some exhibiting unique navigational behaviours. This leads to clear differences in how ant navigators rely on this shared toolbox to reach goals. Species with hybrid foraging structures, which navigate partially upon a pheromone-marked column, express distinct differences in their toolbox, compared to solitary foragers. Here, we explore the navigational abilities of the Western Thatching ant (Formicaobscuripes), a hybrid foraging species whose navigational mechanisms have not been studied. We characterise their reliance on both the visual panorama and a path integrator for orientation, with the pheromone’s presence acting as a non-directional reassurance cue, promoting continued orientation based on other strategies. This species also displays backtracking behaviour, which occurs with a combination of unfamiliar terrestrial cues and the absence of the pheromone, thus operating based upon a combination of the individual mechanisms observed in solitarily and socially foraging species. We also characterise a new form of goalless orientation in these ants, an initial retreating behaviour that is modulated by the forager’s path integration system. The behaviour directs disturbed inbound foragers back along their outbound path for a short distance before recovering and reorienting back to the nest.
Health Belief Model yang Berkembang di Masyarakat pada Kasus Paliatif Care (DM Tipe 2)
Authors: Dewi Nur Sukma Purqoti  , Baiq Ruli Fatmawati  , Amrullah Muhammad , Baiq Heni Rispawati  , Harlina Putri Rusiana  , Ernawati  , Erwin Wiksuarini  
Published: September 2023

Diabetes melitus (DM) adalah penyakit yang belum bisa disembuhkan secara medis sehingga penyakit ini merupakan penyakit degenratif yang biasa disebut dengan lifelong disease. Hal tersebut menjadi faktor utama pentingnya pendekatan perawatan paliatif (palliatif care) pada pasien dengan DM. Studi ini bertujuan untuk mengidentifikasi Health Belief Model (HBM) pada masyarakat terkait dengan penanganan penyakit DM secara paliatif. Penelitian ini menggunakan metode kuantitatif melalui cross sectional study dengan teknik pengambilan sampel iaitu Accidental Sampling menggunakan kriteria sampel iaitu responden dengan usia 40 tahun ke atas yang berasal dari Desa Kopang. Setelah data dikumpulkan kemudian dilakukan analisis data secara univariat. Berdasarkan hasil penelitian, Tingkat kepatuhan terhadap pengobatan yang berkembang di masyarakat pada kasus paliatif care (DM) terdapat 15 (46%), Persepsi kerentanan sebanyak 28 (84%), Persepsi keparahan kemungkinan responden jatuh dalam kategori parah yakni sebanyak 19 (57%), Persepsi manfaat ialah ketika responden mempunyai persepsi manfaat yang lebih tinggi apabila mengikuti program pengobatan DM yaitu sebanyak 20 (61%), Persepsi hambatan sebagian responden memiliki persepsi hambatan yang rendah saat mengikuti program pengobatan DM yaitu sebanyak 18 (54%), Persepsi efikasi diri iaitu terkait dengan adanya kemampuan responden untuk melakukan perilaku mengikuti program pengobatan DM tertinggi yaitu pada kategori tinggi sebanyak 22 (66%), Distribusi isyarat untuk bertindak Terhadap Pencegahan Komplikasi Penyakit DM sebanyak 22 (66%).
Perbedaan Pengaruh Air Rebusan Daun Alpukat (Persea america Mill) dengan Sari Mentimun (Curcumis sativus L) pada Penderita Hipertensi di Jerneng Terong Tawah Tahun 2022
Authors: Putri Ramdaniah  , Depi Yuliana  , Atri Sri Ulandari  , Lelie Amalia T  
Published: September 2023

Hipertensi merupakan masalah kesehatan yang sering terjadi dimasyarakat, dimana keadaan tekanan darah sistolik >= 140 mmHg dan tekanan darah distolik >= 90 mmHg. Terapi hipertensi ada 2, yaitu terapi farmakologi dan non farmakologi, salah satu terapi farmakologi hipertensi, yaitu dengan mengonsumsi minuman herbal salah satunya air rebusan daun alpukat dan sari mentimun.
Penelitian ini menggunakan desain Quasi Eksperimental Dengan Equivalen Group Control dengan rancangan Pretest dan Postest. jumlah sampel pada penelitian ini, yaitu 30 orang yang terdiri dari 1 kelompok kontrol dan 2 kelompok intervensi, air rebusan daun alpukat dan sari mentimun masing-masing diberikan pada sore hari selma 7 hari dengan dosis 250 ml.
Kesimpulan dari penelitian ini di dapatkan hasil analisa pengaruh air rebusan daun alpukat dan sari mentimun diperoleh nilai p = 0,005 < alpha = 0,05 yang berarti terdapat pengaruh penurunan tekanan darah yang signifikan terhadap penderita hipertensi di jerneng terong tawah tahun 2022 . Hasil analisa perbedaan pengaruh penurunan tekanan darah setelah ekperimen antara kelompok intervensi dan kelompok kontrol normal diperoleh nilai p = 0,000 < alpha = 0,05 yang berarti terdapat perbedaan yang signifikan, sedangkan perbedaan pengaruh antara kelompok intervensi air rebusan daun alpukat dan sari mentimun diperoleh p = 0, 184 > alpha = 0,05 pada tekanan darah sistolik dan nilai p = 0,902 > alpha = 0,05 pada tekanan darah distolik, yang berarti tidak ada perbedaan pengaruh pada kelompok intervensi.