bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain history and experimental pressure pain responses in adolescents: Results from a population‐based birth cohort
Authors: Brandão Maria , Talih Makram , Holden Sinead , Fernandes Francisco , Graven‐Nielsen Thomas , Lucas Raquel 
Published: July 2023

AbstractBackgroundSensitized pain mechanisms are often reported in musculoskeletal pain conditions, but population‐based paediatric studies are lacking. We assessed whether adolescents with musculoskeletal pain history had evidence of increased responsiveness to experimental pressure stimuli.MethodsData were from 1496 adolescents of the Generation XXI birth cohort. Pain history was collected using the Luebeck Pain Questionnaire (self‐reported at 13, parent‐reported at 7 and 10 years). Two case definitions for musculoskeletal pain were considered: (1) cross‐sectional—musculoskeletal pain lasting more than 3 months at age 13 and (2) longitudinal—musculoskeletal pain at age 13 with musculoskeletal pain reports at ages 7 and/or 10. Lower limb cuff pressure algometry was used to assess pain detection and tolerance thresholds, conditioned pain modulation effects (CPM, changes in thresholds in the presence on painful conditioning) and temporal summation of pain effects (TSP, changes in pain intensity to 10 phasic painful cuff stimulations).ResultsAdolescents with musculoskeletal pain at age 13 plus a history of pain in previous evaluations (longitudinal definition) had lower pain tolerance thresholds compared to the remaining sample (40.2 v. 49.0 kPa, p = 0.02), but showed no differences in pain detection threshold, CPM effect and TSP effect. Pain sensitivity, CPM effects and TSP effects were not significantly different when the current pain only case definition (cross‐sectional) was used.ConclusionsAdolescents with current musculoskeletal pain who had a history of pain since childhood had lower tolerance to cuff stimulation. This may suggest long‐standing musculoskeletal pain since childhood may contribute to sensitisation, rather than the presence of current pain only.SignificanceRepeated musculoskeletal pain up to age 13 years may contribute to higher pain sensitivity (particularly lowered pressure pain tolerance) in the general adolescent population. This does not seem to be the case when reported pain experiences are recent or when the outcomes are temporal pain summation or CPM. In this community‐based paediatric sample, the vast majority showed no sign of altered pain processing, but a small fraction may reveal some pain sensitization at 13 years of age.
Vaccination against COVID‐19 and potential protective effects on seizure recurrence in children with epilepsy: A cross‐sectional survey
Authors: Chen Congjie , Chen Ningning , Xie Li , Luo Yuanyuan , Ma Jiannan , Li Tingsong 
Published: July 2023

AbstractObjectiveDespite strong evidence on the safety and tolerability of the COVID‐19 vaccine, data on vaccination in children with epilepsy, particular younger children with specific epilepsy syndromes, are limited. The protective effects of vaccination against seizure increase upon COVID‐19 infection also remain to be elucidated.MethodsQuestionnaire surveys were distributed online via an established WeChat group for patient management as well as in our outpatient clinic. The data collected included demographics and clinical information related to COVID‐19 vaccination and infection. Detailed information related to epilepsy diagnosis and treatment was also collected from our patient database. Logistic regression analysis was performed to determine the factors associated with non‐vaccination. The characteristics of seizures following COVID‐19 infection were described.ResultsIn total, 354 suitable questionnaires were included in the study. The median age at survey was 6 years (interquartile range 4, 9). The most common epilepsy syndrome was self‐limited epilepsy (n = 153, 43.2%), followed by developmental and/or epileptic encephalopathy (D/EE, n = 81, 22.9%) and genetic generalized epilepsy (n = 59, 16.7%). The vaccine uptake rate was 43.8% (n = 155), and all related side‐effects (n = 11, 7.1%) remitted spontaneously. Younger age (odds ratio [OR] = 0.877, P = 0.001), D/EE (OR = 5.096, P = 0.008), and less than six months seizure‐freedom before vaccination (OR = 3.026, P = 0.005) were associated with unwillingness to be vaccinated. There were no significant differences in the rate of COVID‐19 infection (33.7% vs 32.7%, P = 0.879) and resultant increased seizure activity following infection between the vaccinated and unvaccinated groups after propensity score matching (9.1% vs 15.6%, P = 0.428).Three unvaccinated cases of Dravet syndrome developed status epilepticus following COVID‐19 infection.SignificanceVaccination against COVID‐19 is safe and well tolerated in children, even in younger patients with D/EE. Although the risk of worsening seizures following COVID‐19 infection may not be reduced by immunization, education focused on increased vaccination in pediatric epilepsy is still warranted.
Impact of aquifer properties on the extent and timeline of CO2 trapping
Authors: Iloejesi Chidera O. , Zhang Shuo , Beckingham Lauren E. 
Published: July 2023

AbstractGeologic CO2 sequestration in porous saline aquifers is a promising approach to reducing atmospheric concentrations of CO2. Reactive transport simulations provide the opportunity to analyze which factors influence geochemical reactivity in the reservoir, understand those most important for promoting CO2 trapping, and assess individual sites. Field‐scale aquifer characterization is time and resource intensive such that here, reactive transport simulations are leveraged to enhance understanding of selected aquifer properties including porosity, permeability, depth of storage, and carbonate mineralogy on the overall CO2 trapping potential to better select sites promoting geochemical reactivity for CO2 trapping. There are different mechanisms for sequestrating CO2. Once injected, CO2 will dissolve into the brine to create an acidic environment, resulting in the dissolution of pre‐injection formation minerals. Released ions can reprecipitate as secondary minerals. The dissolved CO2 and mineralized CO2 are considered as a more secure form of CO2 trapping in this study compared to the free supercritical CO2. Here, a framework leveraging a controlled set of field scale simulations is developed to facilitate rapid, optimized site selection. Simulations vary aquifer properties to understand the impact of each unique property on CO2 trapping, tracking, and comparing the amount of supercritical, aqueous, and mineralized CO2. The rate at which the CO2 injected into the aquifer is converted to aqueous or mineralized CO2 is newly defined here as the sequestration efficiency and used to compare simulation results. The reservoir depth and fraction of carbonate minerals in the formation are shown to be more important factors than reservoir porosity and permeability in affecting CO2 trapping. However, the impact of aquifer properties on the evolution of injected CO2 depends on the stage of the sequestration project. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd.
Has COVID‐19 affected dementia diagnosis rates in England?
Authors: Hazan Jemma , Liu Kathy Y. , Isaacs Jeremy D. , Burns Alistair , Howard Robert 
Published: July 2023

AbstractBackgroundThe COVID‐19 pandemic impacted on the provision of care and routine activity of all National Health Service (NHS) services. While General Practitioner referrals to memory services in England have returned to pre‐pandemic levels, the estimated dementia diagnosis rate (DDR) fell by 5.4% between March 2020 and February 2023.MethodsIn this paper we explore whether this reduction is accurate or is an artefact of the way the NHS collects data.ResultsWe explore the processes that may have affected national dementia diagnosis rates during and following the COVID‐19 pandemic.ConclusionsWe discuss what action could be taken to improve the DDR in the future.
Reconstruction of subtotal pharyngolaryngectomy using a fasciocutaneous free flap with cartilage graft: A case series of 17 patients
Authors: Ghanem Wahib , Qassemyar Quentin , Julieron Morbize , Kolb Frédéric , Leymarie Nicolas , Moya‐Plana Antoine , Janot François , Temam Stéphane , Benmoussa Nadia 
Published: July 2023

AbstractIntroductionSubcricoid‐hemilaryngopharyngectomy (SCHLP) with a reconstruction using a fasciocutaneous free flap armed with cartilage graft (FFACG) aims to avoid permanent tracheostomy while still maintaining the laryngopharyngeal functions. The purpose of this study is to report the outcome of this surgical approach.Materials and MethodsRetrospective study including 17 men operated between 2001 and 2019. Specific survival rate included death caused by cancer or SCHLP complications. Complications, functional and oncological outcomes were evaluated retrospectively.ResultsThere were no locoregional recurrences. One patient died due to inhalation pneumonia 3 years after surgery. Tracheostomy was closed in 13 patients (76.5%). Mean decannulation time was at six [1–14] months after surgery.ConclusionSCHPL with FFACG could avoid total pharyngolaryngectomy with good oncologic results. However, tracheotomy is extended and deglutition recovery is long with high risk of aspirations. These complications justify that such surgery should be realized only on selected patients by experienced surgical teams. Expertise of the surgical team is critical.
Complex visual discrimination is impaired after right, but not left, anterior temporal lobectomy
Authors: Gardette Jeremy , Mosca Chrystèle , Asien Cassandra , Borg Céline , Mazzola Laure , Convers Philippe , Gal Guillaume , Banjac Sonja , Baciu Monica , Durocher Bastien , Kahane Philippe , Hot Pascal 
Published: July 2023

AbstractThe prevailing view in human cognitive neuroscience associates the medial temporal lobes (MTLs) with declarative memory. Compelling experimental evidence has, however, demonstrated that these regions are specialized according to the representations processed, irrespective of the cognitive domain assessed. This account was supported by the study of patients with bilateral medial temporal amnesia, who exhibit impairments in perceptual tasks involving complex visual stimuli. Yet, little is known regarding the impact of unilateral MTL damage on complex visual abilities. To address this issue, we administered a visual matching task to 20 patients who underwent left (N = 12) or right (N = 8) anterior temporal lobectomy for drug‐resistant epilepsy and to 38 healthy controls. Presentation viewpoint was manipulated to increase feature ambiguity, as this is critical to reveal impairments in perceptual tasks. Similar to control participants, patients with left‐sided damage succeeded in all task conditions. In contrast, patients with right‐sided damage had decreased accuracy compared with that of the other two groups, as well as increased response time. Notably, the accuracy of those with right‐sided damage did not exceed chance level when feature ambiguity was high (i.e., when stimuli were presented from different viewpoints) for the most complex classes of stimuli (i.e., scenes and buildings, compared with single objects). The pattern reported in bilateral patients in previous studies was therefore reproduced in patients with right, but not left, resection. These results suggest that the complex visual‐representation functions supported by the MTL are right‐lateralized, and raise the question as to how the representational account of these regions applies to representations supported by left MTL regions.
Assessing the choice of National Health Insurance Fund contracted outpatient facilities in Kenya: A qualitative study
Authors: Kazungu Jacob , Nonvignon Justice , Quaife Matthew , Barasa Edwine 
Published: July 2023

AbstractObjectiveTo assess National Health Insurance Fund (NHIF) members' level of understanding, experiences, and factors influencing their choice of NHIF‐contracted outpatient facilities in Kenya.MethodsWe conducted a cross‐sectional qualitative study with NHIF members in two purposefully selected counties (Nyeri and Makueni counties) in Kenya. We collected data through 15 focus group discussions with NHIF members. Data were analysed using a framework analysis approach.ResultsUrban‐based NHIF members had a good understanding of the NHIF‐contracted outpatient facility selection process and the approaches for choosing and changing providers, unlike their rural counterparts. While NHIF members were required to choose a provider before accessing care, the number of available alternative facilities was perceived to be inadequate. Finally, NHIF members identified seven factors they considered important when choosing an NHIF‐contracted outpatient provider. Of these factors, the availability of drugs, distance from the household to the facility and waiting time at the facility until consultation were considered the most important.ConclusionThere is a need for the NHIF to prioritise awareness‐raising approaches tailored to rural settings. Further, there is a need for the NHIF to contract more providers to both spur competition among providers and provide alternatives for members to choose from. Besides, NHIF members revealed the important factors they consider when selecting outpatient facilities. Consequently, NHIF should leverage the preferred factors when contracting healthcare providers. Similarly, healthcare providers should enhance the availability of drugs, reduce waiting times whilst improving their staff's attitudes which would improve user satisfaction and the quality of care provided.
Factors limiting US public health emergency authority during COVID‐19
Authors: Zhang Xue , Warner Mildred E. , Meredith Gen 
Published: July 2023

AbstractSince the onset of the COVID‐19 pandemic, many states in the United States have limited emergency public health authority. These limits could undermine public health efforts and raise concerns about how states and localities will prevent and respond to future public health challenges. We examined which of the 50 US states passed laws to set limits on public health emergency authority in 2021 through 2022, and their relationship to COVID‐19 death rates. We explored five government characteristics: COVID‐19 policy response, political partisanship (Republican control), legislative professionalism, local government autonomy, and broader non‐COVID‐19 related preemptions. Results of T‐tests and a Generalised Structural Equation Model show that states with unified Republican control had greater odds of limiting emergency public health authority of the state executive, state governor, state health official, and local health officials. Limits of emergency public health authority were associated with a higher COVID‐19 death rate. We found that states setting limits on emergency authority are primarily related to politicisation and political competition between state executives/governors and legislatures, rather than pushback against the COVID‐19 public health response. Limiting emergency public health authority is less common in states with more professional state legislatures. Structural changes related to party control, legislative professionalism, and local autonomy may facilitate public health authority.
Incidental finding of extramammary Paget's disease during active surveillance for early‐stage prostate cancer in a prostate biopsy
Authors: Fujiwara Kengo , Kato Takuma , Ibuki Emi , Kimura Nachino , Kaku Yo , Tsunemori Hiroyuki , Miura Takayoshi , Dainichi Teruki , Haba Reiji , Sugimoto Mikio 
Published: July 2023

IntroductionSkin tissue contamination within transcutaneous visceral organ biopsies is seldom found. We encountered a rare case of extramammary Paget's disease incidentally diagnosed by prostate biopsy during active surveillance for prostate cancer.Case presentationA 71‐year‐old Japanese patient was diagnosed with prostate cancer, and active surveillance was selected. After 1 year, prostate biopsy was performed by a transperitoneal approach, and 16 biopsy cores were taken. One biopsy core contained skin tissue showing extramammary Paget's disease. Careful skin examination confirmed the presence of an extramammary Paget's disease lesion in the left perineum, and curative surgical resection was performed. Recurrence and metastasis did not occur after 6 months of follow‐up.ConclusionAlthough the perianal region is a common site of extramammary Paget's disease, early‐stage extramammary Paget's disease is often asymptomatic. Thus, during a transcutaneous biopsy, it is important to consider the appearance of the skin and the pathological features of migrating skin tissue.
Extraordinarily stable and wide‐temperature range sodium/potassium‐ion batteries based on 1D SnSe2‐SePAN composite nanofibers
Authors: Wang Yiyi , Xiao Fuyu , Chen Xi , Xiong Peixun , Lin Chuyuan , Wang Hong‐En , Wei Mingdeng , Qian Qingrong , Chen Qinghua , Zeng Lingxing 
Published: July 2023

AbstractDeveloping electrodes with long lifespan and wide‐temperature adaptability is crucial important to achieve high‐performance sodium/potassium‐ion batteries (SIBs/PIBs). Herein, the SnSe2‐SePAN composite was fabricated for extraordinarily stable and wide‐temperature range SIBs/PIBs through a coupling strategy between controllable electrospinning and selenylation, in which SnSe2 nanoparticles were uniformly encapsulated in the SePAN matrix. The unique structure of SnSe2‐SePAN not only relieves drastic volume variation but also guarantees the structural integrity of the composite, endowing SnSe2‐SePAN with excellent sodium/potassium storage properties. Consequently, SnSe2‐SePAN displays a high sodium storage capacity and excellent feasibility in a wide working temperature range (−15 to 60°C: 300 mAh g−1/700 cycles/−15°C; 352 mAh g−1/100 cycles/60°C at 0.5 A g−1). At room temperature, it delivers a record‐ultralong cycling life of 192 mAh g−1 that exceeds 66 000 cycles even at 15 A g−1. It exhibits extremely superb electrochemical performance in PIBs (157 mAh g−1 exceeding 15 000 cycles at 5 A g−1). The ex situ XRD and TEM results attest the conversion‐alloy mechanism of SnSe2‐SePAN. Also, computational calculations verify that SePAN takes an important role in intensifying the electrochemical performance of SnSe2‐SePAN electrode. Therefore, this study breaks new ground on solving the polyselenide dissolution issue and improving the wide temperature workable performance of sodium/potassium storage.
image
Regeneration of taste through sonic hedgehog upregulation by photobiomodulation
Authors: Lee Ha Young , Abueva Celine DG. , Padalhin Andrew , Park So Young , Ryu Hyun Seok , Chung Phil‐Sang , Kim Hee Jung , Kim Jeongyun , Woo Seung Hoon 
Published: July 2023

AbstractThis study investigated photobiomodulation (PBM) effects in Sonic hedgehog (Shh) signaling as a potential approach to taste preservation and regeneration. Primary taste cell (TC) cultures were treated with Shh antagonist vismodegib and irradiated using a continuous wave type 630 nm light‐emitting diode (10 mW/cm2) array, with single or multiple doses of 30 J/cm2 to determine dose inducing significant upregulation effect. Shh, Ptch, Smo, and Gli1 were significantly upregulated at 120 J/cm2, used as the minimum dose in vivo. Vismodegib was administered via daily oral gavage for 21 days (30 mg/kg) to induce Shh inhibition in the tongue of rat animal models resulting in taste bud damage and taste dysfunction. PBM treatment using a 630 nm laser (3 W/cm2) at a radiant exposure of 120 J/cm2 (24 J/cm2 × 5) successfully upregulated the Shh protein expression, regenerated taste buds, and recovered taste function.
Evaluation of the interim Cochrane rapid review methods guidance—A mixed‐methods study on the understanding of and adherence to the guidance
Authors: Griebler Ursula , Dobrescu Andreea , Ledinger Dominic , Klingenstein Pauline , Sommer Isolde , Emprechtinger Robert , Persad Emma , Gadinger Arianna , Trivella Marialena , Klerings Irma , Nussbaumer‐Streit Barbara 
Published: July 2023

AbstractThe Cochrane Rapid Review Methods Group (RRMG) first released interim guidance in March 2020 to support authors in conducting rapid reviews (RRs). The objective of this mixed‐methods study was to assess the adherence and investigate authors' understanding of the RRMG guidance. We identified all documents citing the Interim Cochrane RRMG guidance up to February 17, 2022 and performed an exploratory adherence analysis. We interviewed 20 RR authors to assess the recommendations' comprehensibility and reasons for any deviations. Further, we surveyed nine authors of COVID‐19‐related Cochrane reviews for their reasons for not conducting a RR. We analyzed 128 RRs (111 non‐Cochrane, 17 Cochrane) that cited the RRMG guidance. Several recommendations were not followed by a large proportion of RR authors such as stepwise approach to study design inclusion or peer review of search strategies, whereas others were exceeded, for example, dual independent screening of abstracts/full texts. The most reported reasons for deviating from the guidance were time constraints, unclarities in the recommended approach, or inapplicability to the specific RR. Overall, the guidance was viewed as user‐friendly; however, without pre‐existing knowledge of systematic review (SR) conduct, the application was perceived as difficult. The main reasons for conducting a full SR over a RR were late availability of the guidance, preset mandate to conduct a SR, uncertainty regarding methodological distinctions between SR and RR, and inapplicability to the evidence base. Clarifications are warranted throughout the Interim Cochrane RRMG guidance to ensure that users with various experience levels can understand and apply its recommendations accordingly.
Zn2+@Polyvinylpyrrolidone and Urushiol Preparation of Nanofibrous Membranes and Their Synergistic Effect
Authors: Shiu Bing‐Chiuan , Wulin Shihan , Yuan Qian‐Yu , Zhang Ying , Yu Zhicai 
Published: July 2023

AbstractIn this study, lacquer is gathered from a lacquer tree and rotary evaporation is used to remove impurities to obtain urushiol. Next, 10 mL of anhydrous ethanol serves as the solvent for blending polyvinylpyrrolidone (PVP) at a specified content (0.7 g and 0.2–0.7 g urushiol) to form an electrospinning solution. Electrospinning is carried out with a voltage of 18 kV to prepare PVP/urushiol nanofibrous membranes. At a ratio of 7/4, the PVP/urushiol nanofibrous membranes are not eroded in 98% sulfuric acid and these membranes also demonstrate a 50–60% antibacterial effect against Staphylococcus aureus and Escherichia coli. Moreover, the antibacterial effect can be boosted to 98% with the incorporation of zinc ions. The results indicate that anhydrous ethanol can remove the sensitization of urushiol from PVP/urushiol membranes. Furthermore, animal test results indicate that when rats are in contact with PVP/urushiol anhydrous ethanol for 48 h, their skins are free from dark brown skin allergy. The presence of PVP eliminates the sensitization of urushiol, and the nanofibrous membranes demonstrate low toxicity. Hence, urushiol is the only natural material that enables PVP to withstand 98% sulfuric acid as well as acquire hydrolyzability, thereby qualify PVP as a medical material.