bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controllability in Multiplex Biological Networks withInsights into Virus-Related Diseases
Authors: Behrouzinia Soudeh , Khanteymoori Alireza , Dehghanian Fariba 
Published: August 2023

Abstract
Complex networks, inspired by biological systems and grounded in mathematical and computational models, have beenextensively employed to represent diverse biological phenomena. The significance of network controllability in comprehendingintricate biological systems is universally acknowledged, leading to the development of several algorithms aimed at analyzingnetwork controllability. These algorithms serve the purpose of manipulating input signals to guide biological system dynamicstowards desired states. New studies have shown that there are complicated connections between things that are hard to showin simple networks, and this makes us question the idea that things are isolated. In response to these complexities, multiplexnetworks have emerged as robust constructs capable of accommodating and capturing multiple relationships simultaneouslywithin high-dimensional spaces. This research introduces a novel framework designed to regulate the behavior of biologicalmultiplex networks through the identification of pivotal driver nodes. This challenge is formulated as the identification ofminimum driver nodes, with the framework’s efficacy evaluated through its application to authentic biological multiplexes.Applied to three virus multiplexes, the framework underscores the potential for specific nodes to serve as targets for drugenrichment or as subjects for the investigation of intricate diseases. The implications of this research extend to the identificationof potential driver genes for a variety of virus-related diseases within the landscape of biological multiplex networks.
Prolonged Administration of the Granisetron Transdermal Delivery System Reduces Capecitabine plus Oxaliplatin Regimen–Induced Nausea and Vomiting
Authors: Wang Cong , Jiang Zhansheng , Zhang Jie , Zhuang Yan , Sun Lining , Zhang Jing , Quan Manman , Lan Lan , Li Yanwei , Wang Bin , Pan Zhanyu , Yan Zhuchen 
Published: August 2023

Abstract

Purpose
The completion rate and intensity of Capecitabine plus oxaliplatin (CapeOX) combination therapy are low in clinical practice because of chemotherapy-induced nausea and vomiting. This open-label, prospective, multi-center phase II trial was designed to initially assess the safety and efficacy of granisetron transdermal delivery system (GTDS) and Dexamethasone for patients who were scheduled to receive CapeOX chemotherapy.
Methods
Patients received the GTDS (3.1 mg attached to the upper arm 48 h before chemotherapy, replaced on day 5 and discarded on day 12), and Dexamethasone. The primary end point was complete control rate. Secondary efficacy endpoints included dates of delayed complete control during the overall phase, complete control rate in the acute phase, safety and quality of life.
Results
Among three institutions, 29 participants were enrolled in the study. The complete control rate in delayed nausea and vomiting for the whole periods (25–480 hours) was 70.4% (95% CI 0.50–0.86). The dates of delayed complete control were 17.1 ± 4.9 days. 59.3% of patients did not experience any grade of nausea during the delayed phase. The complete control rate in the acute phase was 85.2% (95% CI 0.65–0.95). In terms of safety, there were no serious adverse events attributed to the antiemetic regimen.
Conclusion
Prolonged administration of the GTDS is safe and effective for preventing chemotherapy-induced nausea and vomiting in patients with gastrointestinal malignancies treated with CapeOX. This study is registered at the ClinicalTrials.gov registry (NCT05325190). The date of registration was October 10, 2021.
Cellulose-based surface-modified heterogeneously feasible novel solid acid catalyst to access bioactive heterocycles
Authors: Karhale Shrikrishna , Kadam Ankush 
Published: August 2023

Abstract
Surface-modified cellulose-based heterogeneously active catalyst was prepared by covalent anchoring of chlorosulphonic acid on amino-functionalized cellulose (SA@Cell-AEPC). The structure of synthesized catalyst was confirmed by analytical methods such as FT-IR, FE-SEM, EDX, TGA and CP/MAS 13C-NMR spectroscopy. The catalytic effect was evaluated for the formation of oxygen and nitrogen heterocycles. Reusability, shorter reaction time, high conversion, wide substrate scope, easy work-up procedure are noteworthy measures of this synthetic route.
Pair barracuda swarm optimization algorithm a natural-inspired metaheuristic method for high dimensional optimization problems
Authors: Guo Jia , Zhou Guoyuan , Ke Yan , Sato Yuji , Di Yi 
Published: August 2023

Abstract
The high-dimensional optimization is a new research difficulty in the field of intelligent computing.Traditional evolutionary tools are prone to dimensional catastrophes and local optimal in high dimensional spaces, thus failing to provide highly accurate results. In this paper, to solve the high-dimensional optimization problem, a novel pair barracuda swarm optimization algorithm (PBSOA) is proposed. In PBSOA, a novel construction of barracuda pairs is proposed to reduce dimensional catastrophes.A support barracuda is also used to enhance the global search ability of the leader barracuda pair.To verify the performance of the barracuda algorithm, the CEC2017 standard function is used for experiments, and five excellent optimization algorithms are selected in control groups. Finally, in a total of 29 test functions, PBSOA gets 18 firsts, 4 seconds, 3 thirds, 3 fourths, and 1 sixth, and the average rank is 1.83.The experimental results demonstrate that PBSOA presents the best performance in all algorithms and is able to provide trustworthy results for high-dimensional optimization problems.
Identification and analysis of dysregulated genes in the pathogenesis of keloid
Authors: Tao Anqi , Tian Tian 
Published: August 2023

Abstract
Objective
Keloid is a fibroproliferative disorder that primarily arises from cutaneous traumas. However, the pathogenesis of keloid remains uncertain and is likely involved in multiple signaling pathways and is likely involved in multiple signaling pathways. This study aims to identify the key signaling pathways and explore the potential roles of immune cells in keloid development.
Methods
Two keloid datasets, GSE44270 and GSE145275 from, obtained from the Gene Expression Omnibus (GEO) database, were integrated with the elimination of batch effects. Differentially expressed genes (DEGs) were identified using the Linear Models for Microarray Data (LIMMA) package. The Weighted Gene Co-expression Network Analysis (WGCNA) was then applied to identify keloid-associated genes. The common genes (CGs) were subsequently obtained by overlapping the DEGs with genes in the most significant module. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using these CGs. Additionally, the CIBERSORT algorithm was used to calculate the relative proportions of 22 types of infiltrating immune cells.
Result
We identified 51 DEGs using the R package limma. 18 modules were constructed via WGCNA, with the pink module showing the highest correlation with keloid and was further intersected with the DEGs to obtain 28 CGs. Pathway enrichment analysis revealed that the CGs were primarily associated with the regulation of transcription and O-glycan biosynthesis. Furthermore, immune infiltration analysis demonstrated significant changes in the levels of macrophages, T cells gamma delta and NK cells compared to the control group.
Conclusion
This study revealed several novel keloid-associated genes that can induce inflammatory response immune cell infiltration and extracellular matrix deposition, ultimately resulting in the development of keloid disorder.
The YOLO model that still excels in document layout analysis
Authors: Deng Qilin , Ibrayim Mayire , Hamdulla Askar , Zhang Chunhu 
Published: August 2023

Abstract
Document layout analysis can help people better understand and use the information in a document. However, the diversity of document layouts and considerable variation in aspect ratios among document objects pose significant challenges. In this study, we designed the Multi-Convolutional Deformable Separation (MCDS) module as the main structure of the network, using the YOLO model as a baseline. Integration of this module into the Backbone and Neck layers enhances the image feature extraction process significantly. Moreover, we incorporate ParNet-Attention to direct the network's focus toward document objects through parallel networks, thereby facilitating a more exhaustive feature extraction. To optimize the model's predictive potential, the Decouple Fusion Head (DFH) is employed within the Head layer. This technique leverages multi-scale features based on the decoupled head, thereby enhancing the accuracy of predictions. Our proposed model achieves remarkable performance on three distinct public datasets with varying characteristics, namely ICDAR-POD, PubLayNet, and IIIT-AR-13K. Notably, in ICDAR-POD, both IoU$_{0.6}$ and IoU$_{0.8}$ achieve the optimal mean Average Precision (mAP), 96.2 and 94.4, respectively.
Time-Varying Impact of US Monetary Policy Spillovers on Small Open Economies: Evidence from Indonesia
Authors: Saba Danladi N , Sanusi Aliyu Rafindadi 
Published: August 2023

Abstract
This study examines the impact of the US monetary policy spillover on Indonesia’s macroeconomic and financial variables using quarterly data for the period 2000–2020 for both domestic and US variables. We use the impulse responses obtained from an estimated Time-Varying VAR model with stochastic volatility to examine the response of real GDP, inflation, exchange rate, stock market return, and monetary policy rate to US monetary policy shock. We find that US monetary policy spillovers, on average, boost Indonesia’s real GDP, stock market returns, and bilateral exchange rate vis a vis the US Dollar but also trigger domestic inflation beyond what Indonesia’s policy reaction could counteract. However, there are considerable differences in the response of the variables to easing and tightening shocks, on the one hand, and conventional vs unconventional monetary policy, on the other. Finally, we found substantial time variation corresponding to major global events, including the Global Financial Crisis and implementation of unconventional monetary policy, the taper tantrum of 2013-2014, and the great lockdown in the wake of the Covid-19 pandemic in 2019-2020.
Quality of breaking bad news to patients diagnosed with neoplasia of the uterine cervix
Authors: Blanckenburg Pia , Köhler Christhardt , Petzel Anja , Jülicher Anne , Schneider Viola , Schneider Achim 
Published: August 2023

Abstract
Objective
Little is known about the quality of receiving bad news (BN) for women diagnosed with cervical neoplasia. We evaluated adherence to the SPIKES protocol in three cohorts of women with different stages of the disease and treatment modalities.
Patients and Methods
We included women with cervical cancer who underwent radical vaginal trachelectomy (RVT group, n=110), radical hysterectomy or chemo-radiation (HE/RCT group, n=101), and women with CIN 3 treated by loop excision (CIN group, n=108). We asked the participants about how they received the bad news delivery in reality and how they would envision an ideal communication process based on the main items of the SPIKES protocol. The participants filled out a questionnaire with 38 items of the Marburg Breaking Bad News (MABBAN) Scale representing the six SPIKES subscales.
Results
Only 55% of all patients reported being satisfied with their BBN experience. The following factors were considered important by 90% of the patients: an undisturbed atmosphere, taking enough time, coherent explanation of the disease, and the possibility to ask questions. However, the reality of their experiences fell significantly short of their expectations. Asking about the patient's knowledge of the disease, addressing their concerns, allowing them to show emotions, providing clarity about the change in quality of life, informing them about alternative therapies, and involving them in further planning were also significantly lacking in the actual BBN encounters compared to the patients' preferences. The experience of RVT patients was more negative compared to the HE/RCT patients (p = 0.036). The CIN patients had an overall satisfactory impression (p<.0001).
Conclusion
The process of breaking bad news in German women diagnosed with cervical neoplasia requires substantial improvement. The SPIKES protocol can be used as a guideline for enhancement but should be supplemented by incorporating a second interview and triadic consultation as the norm rather than the exception. Continuous monitoring and improvement of the quality of BBN is recommended for all oncologic institutions, utilizing the MABBAN questionnaire as a valuable tool.
Recrudescent plasmodium falciparum malaria after head trauma: a case report with novel clinical perspective
Authors: Liu Shiwen , Wang Xing , Ni Qian , Lu Yi , Wu Danni , Wu Zeqian , Fu Bin , Sun Xi 
Published: August 2023

Abstract
Malaria is a common infection disease in tropical regions, among which cerebral malaria caused by Plasmodium Falciparum remains an enormous threat. Recrudescence of Plasmodium falciparum malaria makes it hard to eliminate the disease of malaria. Many factors that can lead to immune suppression are believed to have the function of causing malaria recrudescence, but whether traumatic brain injury can trigger it remains unclear. Here we present a Plasmodium Falciparum malaria patient who had explicit traumatic brain injury history just before the onset of his symptoms of cerebral malaria. Besides, the progression of his cerebral malaria is much more rapid than normal. Throughout the case report we discuss a new provoking factor that may promote the recrudescence of Plasmodium Falciparum malaria and propose a novel perspective to avoid or reduce acute kidney injury in patients with cerebral malaria.
Fiscal Decentralization and Structural Involution in Developing Countries
Authors: Wiryawan Bangkit A. 
Published: August 2023

Abstract
Fiscal decentralization has been labeled as the silent change in the world's development. The main purpose of this policy is to increase growth and equality in country's sub-national level as well as promote openness and accountability. This in turn would lead to productive structural transformation when combined with industrial policy. However, my finding suggests that the reversal is true. Using data derived from IMF's Government Financial Statistics for the period between 1995 and 2017, it is found that fiscal decentralization has led to structural involution where the output share of agriculture increased at the cost of declining share of other sectors, particularly the industry sector. The result is particularly robust for low and lower-middle income country groups as well as under different estimation method. The phenomenon goes in line with premature decentralization narrative. These findings call, among others, for the prior need of a strong institutional capacity at the local level in order to mitigate local elite capture and rent-seeking. With stronger central-local collaboration, vertically-coordinated industrial policy between multi-level of governments could kick in to support productive transformation.
JEL: E26, H50, H72, O11
Coexistence of Plasmid-mediated Quinolone Resistance (PMQR) and Extended Spectrum β-lactamases (ESBLs) genes among clinical Pseudomonas aeruginosa isolates in Egypt
Authors: Abdelrahim Soha S. , Hassuna Noha A. , Waly Nancy G. F. M. , Kotb Dalia N. , Abdelhamid Haitham , Zaki Shaimaa 
Published: August 2023

Abstract
Background: The rapid increasing prevalence of resistant P. aeruginosato widely used broad spectrum antibiotics as fluroquinolones and cephalosporins has become a matter of serious concern. Plasmid-mediated quinolone resistance (PMQR) have been recently identified as an emerging clinical problem among extended spectrum β-lactamases (ESBLs) producing gram negative bacteria.
Methods: A total of 56 P. aeruginosa strains isolated from 330 patients with different infections were investigated for fluoroquinolone resistance phenotypically. Molecular methods were used to screen for 6 PMQR determinants among the fluoroquinolone-resistant isolates and for 3 ESBL genes among cephalosporin resistant isolates.
Results: Overall, 22/56 (39.3%) of studied P. aeruginosa isolates were resistant to one or both tested fluoroquinolones. PMQR-producing P. aeruginosa isolates were identified in 20 isolates (90.9%). The acc(6ʹ)-1b-crwas the most prevalent PMQR gene (77.3%). The qnr genes were occurred in 72.7% of isolates. The qnrA gene was the most predominant 54.5%, followed by qnrS gene 27.3%, then each of qnrB and qnrC22.7%. The qepA was not detected in any isolate. The remarkable result of the current study was the high co-carriage of PMQR genes among the quinolone resistant isolates. Association of acc(6ʹ)-1b-cr with qnr genes was detected in 65% of positive PMQR isolates. Gene profiles carrying more than 2 PMQR genes were prevalent in P. aeruginosa isolates from wound and ear discharge. The ESBL genes were detected in 52% of cephalosporin resistant P. aeruginosa isolates. The most frequent ESBL gene was blaCTX-M(76.9%) followed by blaTEM (46.2%). Co-carriage of blaTEM and blaCTX-Mwas found in 23%. No isolates carried blaSHV. The ESBL genes positive isolates showed a significant higher resistance to non-beta lactam antibiotics. Regarding co-existence of PMQR and ESBL genes, at least 1 ESBL gene was found in 75% of PMQR-positive isolates. The acc(6ʹ)-Ib-cr gene showed the highest association with ESBL genes followed by qnrA gene. The correlation matrix of detected PMQR and ESBL genes indicated overall positive correlations. The strongest and highly significant correlation was between qnrAand acc(6ʹ)-Ib-cr (r = 0.602) and between qnrA and blaCTX-M (r = 0.519).
Conclusion: The worldwide increased prevalence of ESBL producing and fluoroquinolone resistant P. aeruginosa strains became a serious threat to public health and a great challenge to treatment options. Studied P. aeruginosa isolates exhibited coexistence of PMQR and ESBL genes.
Evolving Parameters of Shewhart Control Chart from Present-day Industrial Engineering Perspective
Authors: Sandeep  , Mukhopadhyay Arup Ranjan 
Published: August 2023

Abstract
The implementation of control charts for controlling processes based on statistical principles often requires answering questions like what should be the sample size (n), the sampling interval (h), and the control limits’ multiplier (k). This work, inspired by Duncan and other authors like Gibra, I.N. and Saniga, E.M., etc., has evolved from certain practical considerations in an industry. Duncan in his economic design considered parameters like loss due to false alarm, the average cost of finding an assignable cause, the hourly cost of process control, and average income from in-control and out-of-control processes. However, the proposed model has considered additional parameters like production rate, sampling cost, sample preparation cost, testing cost, energy cost, consumables cost, and reporting cost from the perspective of production engineering. The economic model thus developed has been tailored to encapsulate the journey from Duncan to the contemporary period. The model has been appropriately optimized to determine n, h, and k. The effectiveness of the procedure has been demonstrated through numerical examples, comparative enumeration, and sensitivity analysis. The work is expected to transcend the much-hyped divide between theory and practice in the parlance of statistical process control.
Implications of Herbal Components in the Treatment of Neurological
Disorders
Authors: Ali Daud , Verma Swati , Malviya Rishabha , Mishra Shuchita , Sundram Sonali 
Published: August 2023

Abstract:
Herbal components have been explored as a potential alternative treatment for neurological
disorders due to the limitations and potential adverse effects of conventional treatments. Alzheimer’s
disease is the most prevalent progressive human neurodegenerative condition marked by
senile plaques and neurofibrillary tangles as well as gradual cognitive impairments; the most prominent
of which is memory loss. Different therapy techniques incorporating synthetic and herbal
approaches are being employed against AD based on the knowledge of the disease process. Commonly
used herbal components, such as Ginkgo biloba, Bacopa monnieri, Withania somnifera,
Passiflora incarnata, Rhodiola rosea, and Curcuma longa, have been shown to improve symptoms
and cognitive function in individuals with neurological disorders, such as Alzheimer’s disease, Parkinson’s
disease, and multiple sclerosis. However, more research is needed to fully understand the
efficacy, safety, and potential interactions with other medications. By continuously exploring and
researching the use of herbal components for neurological disorders, we can develop a better understanding
of their potential to offer safe and effective alternative treatments.
Potential Therapeutic Applications for Isolinderalactone in Medicine for
the Treatment of Cancers and other Human Complications: An Overview
of Medicinal Importance
Authors: Patel Dinesh Kumar , Patel Kanika 
Published: August 2023

Background:
Herbal medicines have been used in both traditional and modern medicine
for the treatment of numerous kinds of human disorders and associated secondary complications.
Lindera species has an important place in traditional medicine and provides a great source of
structurally diverse molecules with important pharmacological potential. Lindera strychnifolia is
used as remedies for the treatment of menstruation complications, frequent urination, and
vomiting. Isolinderalactone is a sesquiterpene class phytochemical isolated from the root extracts
of Lindera aggregate.

Methods:
Biological importance and pharmacological activities of isolinderalactone have been
investigated in the present work through scientific data analysis of different scientific research
work. Scientific data on isolinderalactone have been collected from Google, Google Scholar,
ScienceDirect, PubMed and Scopus using the terms isolinderalactone, Lindera species, and
terpenes and analyzed in the present work in order to know its therapeutic potential in medicine.

Results:
Present work signified the biological importance of isolinderalactone in medicine, which
can modulate several physiological functions in the human body. Isolinderalactone exhibits distinct
anticancer profiles both in vitro and in vivo. Present review data signified the biological importance
of isolinderalactone in medicine, as it exhibits significant potential on human ovarian cancer cells,
glioblastoma, breast cancer, and non-small cell lung cancer. Furthermore, its biological
effectiveness is mainly because of its anti-inflammatory activity, prolyl endopeptidase inhibitory
potential, angiogenic activity, and anti-metastatic effect in medicine. The present study also
summarized the biological significance of Lindera species and sesquiterpenoids in medicine
reported for different pharmacological activities.

Conclusion:
The present work highlighted the biological importance and therapeutic potential of
isolinderalactone in medicine.
COVID-19 – czas na wnioski Istniejące budynki a możliwość izolowania ludzi
Authors: Wieczorek Anna 
Published: August 2023

Celem artykuł jest zwrócenie uwagi decydentom, że istniejące w Polsce budynki nie są przystosowane do izolowania od siebie ludzi, zalecanego w stanie epidemii COVID-19. Dotyczy to nie tylko budynków, w których się mieszka czy pracuje, ale i obiektów służby zdrowia. Słowa kluczowe: epidemia COVID-19, izolacja, kwarantanna, choroba zakaźna