bluuebunny/crossref_metadata_2025_split huggingface dataset:
Students’ Learning Obstacle in Solving Statistical Reasoning Problems: Epistemological Study
Authors: Gunadi Farid , Herman Tatang , Prabawanto Sufyani 
Published: January 2023

In some cases, Statistical learning only applies some formulas without paying attention to developing students’ reasoning ability. So, statistical learning can cause missed conception to the students. A teacher should identify the students’ learning obstacles to achieve the learning objectives. This study aims to know the students’ learning obstacles in solving statistical reasoning problems from two aspects. The first is from the emic aspect; it is a student's viewpoint toward solving the statistical problem. The second is from the aspect of ethics; it is a student viewpoint toward the teacher’s teaching technique done in teaching statistics. This qualitative study employs the explorative case study with epistemology study to discuss the students’ learning obstacles. From the test result and interview of three participants, it is concluded that the students face some obstacles in statistical reasoning problem-solving. The teacher also still used conventional methods in teaching the students.
Faktor-Faktor yang Berhubungan dengan Penyalahgunaan Alat Kontrasepsi Kondom Pada Remaja di Desa Mopusi Tahun 2022
Authors: Hafsia Khairun Nisa Mokodompit  
Published: January 2023

Perilaku seksual remaja merupakan persoalan yang rumit, dipengaruhi oleh berbagai faktor baik dari dalam maupun dari luar diri remaja. Karakteristik remaja atau personal, keluarga dan faktor di luar keluraga seperti media dan lingkungan pergaulan dapat mempengaruhi aktivitas seksual remaja. Remaja berkembang tidak dalam lingkungan isolasi, tetapi dalam lingkungan yang luas yaitu keluarga, media dan linkungan pergaulan. Tujuan penelitian ini Untuk mengetahui Faktor-Faktor Yang Berhubungan Dengan Penyalahgunaan Alat Kontrasepsi Kondom Pada Remaja Di Desa Mopusi. Metode penelitian yang digunakan dalam penelitian ini adalah analitik kuantitatif dengan menggunakan pendekatan cross sectional dengan menekankan waktu pengukuran dan observasi data antara variabel dependent dan independent serta dilakukan satu kali pada satu saat (point time approach) secara simultan. Hasil penelitian didapatkan Sebagian besar remaja tinggal di lingkungan keluarga yang baik 42 responden (84,0%) dengan nilai P Value = 0,902> 0,05. Sebagian besar responden remaja di desa mopusi menggunakan media dengan baik 30 responden (60,0%) dengan nilai p value 0,133>0,05. Sebagian besar remaja yang berada di lingkungan pergaulan yang baik sebesar 31 remaja (62,0%) dengan value 0,000<0,05.kesimpulan dari penelitian ini Terdapat hubungan yang signifikan dan bermakna antara faktor-faktor lingkungan pergaulan dan faktor lingkungan keluarga
Hubungan Peran Bidan dan Dukungan Suami dengan Kepatuhan Imunisasi TT pada Ibu Hamil Primigravida di Wilayah Kerja Puskesmas Maccini Sawah Makassar
Authors: Muzayyana  , Sitti Nurul Hikma Saleh  , Agustin  , St. Rahmawati Hamzah  , Ani  
Published: January 2023

Imunisasi Tetanus Toksoid adalah proses untuk membangun kekebalan sebagai upaya pencegahan terhadap infeksi tetanus. Pelaksanaan kegiatan imunisasi TT ibu hamil terdiri dari kegiatan imunisasi rutin dan kegiatan tambahan. Kegiatan imunisasi rutin adalah kegiatan imunisasi yang secara rutin dan terus-menerus harus dilaksanakan pada periode waktu yang telah ditetapkan. Imunisasi TT masih menjadi masalah serius di Kelurahan Maccini Sawah, di karenakan kasusnya meningkat setiap tahun. Tujuan dari penelitian untuk mengetahui Hubungan Peran Bidan dan Dukungan Suami Dengan Kepatuhan Imunisasi TT Pada Ibu Hamil Primigravida Di Wilayah Kerja Puskesmas Maccini Sawah Makassar. Metode dalam penelitian menggunakan penelitian kuantitatif dengan pendekatan Cross Sectional yaitu suatu penelitian yang mempelajari hubungan antara faktor risiko dengan faktor efek, Populasi dalam penelitian ini adalah semua ibu hamil primigravida yang datang berkunjung di Wilayah Kerja Puskesmas Maccini Sawah Makassar sebanyak 43 orang, Teknik pengambilan sampel secara Purposive Sampling yaitu pengambilan responden dengan membatasi kriteria yang ditetapkan dengan total sampel 30 responden, instrumen penelitian yang digunakan yaitu kuesioner dimana untuk variabel peran bidan memiliki 10 item pertanyaan dengan menggunakan skala gutman dan dukungan suami memiliki 10 item pertanyaan dengan menggunakan skala gutman. Data yang dikumpulkan dalam penelitian diproses secara analitik dengan uji Chi Square dan hasil tersebut akan diolah untuk menentukan adanya hubungan antara kedua variabel independen dan variabel dependen. Hasil penelitian terdapat hubungan antara ada hubungan peran bidan dengan kepatuhan imunisasi TT ibu primigravida dengan nilai p=0,001. Hasil penelitian menunjukkan bahwa ada hubungan dukungan suami dengan kepatuhan imunisasi TT ibu primigravida dengan nilai p= 0,005. Tanpa adanya peran tenaga Kesehatan khususnya bidan dan dukungan suami kepatuhan ibu hamil dalam melakukan imunisasi TT tidak akan bisa berjalan dengan baik karena bidan memberi informasi atau nasehat verbal dan non verbal dan suami memberikan dukungan sosial, dukungan tersebut biasanya diinginkan dari orang-orang penting yang memiliki derajat keterlibatan erat dengan ibu hamil.
Hubungan Dukungan Keluarga dengan Kepatuhan Terapi Pada Penderita Hipertensi di Wilayah Kerja Puskesmas Bilalang
Authors: Astuti Windi , Akbar Hairil 
Published: January 2023

Hipertensi merupakan penyebab penyakit kardiovasikular paling umum diseluruh dunia. Bila tidak dikelolah dengan baik, hal ini terkait dengan komplikasi pada berbagai organ seperti risiko stroke dan penyakit jantung koroner. Kasus hipertensi pada tahun 2018 Provinsi Sulawesi Utara terutama berumur 18 tahun ke aatas berada peringkat pertama pengidap hipertensi karena mencapai 13,14%. Tujuan penelitian untuk mengetahui hubungan dukungan keluarga dengan kepatuhan terapi pada penderita hipertensi di Wilaya Kerja Puskesmas Bilalang. Jenis penelitian ini adalah kuantitatif dengan menggunakan desain studi cross sectional. Penelitian ini di laksanakan di wilayah kerja Puskesmas Bilalang. Populasi penelitian ini semua pasien hipertensi yang berada di wilayah kerja Puskesmas Bilalang. Jumlah sampel secara keseluruhan adalah 50 pasien. Teknik pengambilan sampel dilakukan secara simple random sampling. Analisis data menggunakan uji Chi-square. Hasil penelitian ini menunjukan terdapat hubungan antara dukungan keluarga dengan kepatuhan terapi pada penderia hipertensi di wilayah kerja Puskesmas Bilalang dengan p-value=0,004. Setiap keluarga harus memberikan dukungan kepada anggota keluargannya yang akan melakukan proses terapi penyakit hipertensi agar tidak terjadi komplikasi penyakit jantung dan stroke.
Quality of Sleep Among Shift Work Nurses at the Baguio General Hospital: A Pilot Cross - Sectional Study
Authors: Andaya Kathrynne Endenna 
Published: January 2023

ABSTRACTObjective: The primary objective of this study was to determine the quality of sleep among 12- hour shift-work nurses at the Baguio General Hospital using the Pittsburg Sleep Quality Index (PSQI).

Methods: This was a preliminary cross-sectional study with a primary endpoint of assessing the sleep quality of the participants using the PSQI. The association of sleep quality with individual and work factors was also determined.

Design:Cross - Sectional Study
Setting:Tertiary Government Training Hospital
Patient:154 12-hour shiftwork nurses

Results: The majority (88.96%) of the participants self-reported having poor sleep quality. Among the components of the PSQI, current shift was significantly associated with habitual sleep efficiency (Fisher exact test p < .049). No significant associations were found between demographic characteristics and PSQI Global score, with most respondents having poor sleep quality regardless of participant characteristics.

Conclusion: Majority of nurses working in 12-hour shifts had poor sleep quality. Night shift nurses had higher habitual sleep efficiency scores compared to day shift nurses indicating that those working in the night shift had poorer habitual sleep efficiency.
The Complete and Two-Turn Cochlear Duct Length Among Filipinos
Authors: Kasilag, MD Raiza Michaella , Aquino-Diaz Kathrina 
Published: January 2023

ABSTRACTObjective: This study aims to measure the complete and two-turn cochlear duct lengths in a Filipino population using archived CT scan images.

Methods:
Design: Retrospective Review of Records
Setting:Tertiary Government Training Hospital
Participants: CT Scan Images of 255 patients

Cochlear images of patients who underwent cranial, facial, orbital, paranasal sinus and temporal bone CT scans from January 2019 to December 2019 were analyzed. Coronal oblique images from 3D multiplanar reconstructions were obtained and a single linear measurement (‘A’ value) was used as the spiral coefficient to calculate the complete cochlear duct length (CDL) and two- turn length (2TL).

Results: A total of 510 cochlear images were obtained from the CT scan images of 255 subjects (143 males, 112 females aged 1 to 81 years; mean age = 47 years). The mean ‘A’ value was 8.81 mm (SD = 0.20). The mean complete cochlear duct length was 32.68 mm (31.01 mm – 35.50 mm; SD = 0.834) while the mean two-turn cochlear duct length was 29.61 mm (28.14 mm – 32.08 mm; SD = 0.732). The complete and two-turn cochlear duct lengths in males were found to be significantly longer than in females (p = .001). No significant difference was found between cochlear measurements for left and right ears.

Conclusion: The mean complete cochlear duct length among Filipinos in our study measures 32.68 mm while the mean two-turn cochlear duct length measures 29.61mm. Both complete and two-turn cochlear duct lengths were longer among Filipino males than among females.
A New Extraoral Closed Reduction Technique for Temporomandibular Joint Dislocation: A Preliminary Case Series
Authors: Sangalang Marice , Gansatao Fatima , Dizon Alfred Peter Justine , Onofre-Telan Rubiliza 
Published: January 2023

ABSTRACTObjective: This study aims to describe a new extraoral technique for reducing bilateral temporomandibular joint (TMJ) dislocations.

Methods:
Design: Retrospective Preliminary Case Series
Setting: Tertiary Government Training Hospital
Participants: Ten (10) adults with bilateral TMJ dislocation

Results: Ten patients, 7 males and 3 females with median age of 35.50 (IQR:21.25 [23.50, 44.75]) years old were included in our series. Seven had more than one previous episode of TMJ dislocation, and the dislocation spontaneously occurred while yawning or eating in six patients. Our new technique resulted in complete bilateral reduction in three patients who had first-episode TMJ dislocations but only in four out of seven with previous dislocation. The three others (two partial, unilateral failure of reduction and one complete failure of reduction) needed conventional extraoral reduction (Hippocratic technique).

Conclusion: This new extraoral technique may show promising preliminary results in the management of temporomandibular joint dislocation, but a larger trial in comparison with other techniques is needed.
Contents Vol. 37 No.2 July-December 2022
Authors: Philipp J Otolaryngol Head Neck Surg  
Published: January 2023

EDITORIAL
4
Truth and Transparency, Compromise and Climate Change
Lapeña JFF

GUEST EDITORIAL
6
COP27 Climate Change Conference: Urgent Action Needed for Africa and the World
Atwoli L, Erhabor GE, Gbakima AA, Haileamlak, A, Kayembe Ntumba JM, Kigera J, Laybourn-Langton L, Mash R, Muhia J, Mulaudzi FM, Ofori-Adjei D, Okonofua F, Rashidian A, El-Adawy M, Sidibé S, Snouber A, Tumwine J, Yassien MS, Yonga P, Zakhama L, Zielinski C
ORIGINAL ARTICLES
8
Hearing and Clinical Otologic Profile of Filipinos Living in Southern Tagalog Region IV-A (CALABARZON), Philippines: The Southern Tagalog ENT Hearing Specialists (STENTS) Survey 2012-2017
Pardo PJM, Niñal-Vilog A, Acuin JM, Calaquian CME, Onofre- Telan RDC
16
The Complete and Two-Turn Cochlear Duct Length Among Filipinos
Kasilag RMA, Aquino-Diaz K
20
Quality of Life Among SARS-CoV-2 (COVID-19) Positive Patients with Anosmia Using the Short Version Questionnaire of Olfactory Disorders - Negative Statements Translated in Filipino (sQOD-NS Ph)
Mallari-Bernarte A, Cruz ETS
26
Quality of Sleep Among Shift Work Nurses at the Baguio General Hospital: A Pilot Cross-Sectional Study
Andaya KES
30
Initial Outcomes of Endoscopic CO2 Laser Posterior Cordectomy and Partial Arytenoidectomy Among Patients with Bilateral Vocal Cord Paralysis: A Case Series
Velasco KJS, de la Cruz APC, Carrillo RJD, Madrid DAD
34
A New Extraoral Closed Reduction Technique for Temporomandibular Joint Dislocation: A Preliminary Case Series
Sangalang MB, Gansatao FM, Dizon APJE, Onofre-Telan RDC

CASE REPORTS
38 Airway Obstruction from Intralaryngeal Extension of Thyroglossal Duct Cyst in an Elderly Man: A Case Report
Contreras GS, Lingan MB
42
Multifocal Tuberculosis Presenting as Mandibular Swelling in a 3-Year-Old Boy: A Case Report
Yambot KKK, Peñaflor NAI
SURGICAL INNOVATIONS AND INSTRUMENTATION
46
A Makeshift Blue Light Filter for Endoscopic Identification of Traumatic Cerebrospinal Fluid Leak Using Fluorescein Edora BDE, Chua RU,
Estolano PJL
FEATURED GRAND ROUNDS
50
Hearing Loss from S. Suis Meningitis in a Middle-Aged Couple
Martinez NV, Hosojima MS

FROM THE VIEWBOX
53
Can I Diagnose a Vestibular Schwannoma Using Non-Contrast Imaging?
Yang NW

UNDER THE MICROSCOPE
55
Intercalated Duct Adenoma of the Parotid Gland
Aquino JB, Carnate JM

LETTERS TO THE EDITOR
57
Otitic Hydrocephalus or Obstructive Hydrocephalus?
Yang NW

58
Response from the Authors
Plumo CGT, Cruz ETS

CAPTOONS
60
Doknet’s World
Billones WU
SERUM ANTIBODIES AGAINST GroEL AS AN ADDITIONAL RISK BIOMARKER OF BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMYSERUM ANTIBODIES AGAINST GroEL AS AN ADDITIONAL RISK BIOMARKER OF BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY
Authors: Grygorenko V. , Afanasiev Ye. , Danylets R. , Vikarchuk M. , Shulyak O. 
Published: January 2023

Background: The level of heat shock protein 60 (Hsp60) is elevated in tumor cells compared with normal prostate epithelium. Hsp60 is involved in tumor growth, invasion, and metastasis and is considered as a biomarker for cancer diagnosis and prognosis. Aim: To study the level of antibodies against prokaryotic homolog of human Hsp60 (GroEL) in prostate cancer (PCa) patients as an additional risk marker for the prediction of biochemical recurrence after radical prostatectomy (RP). Patients and Methods: A total of 55 patients with localized and locally advanced PCa, who had undergone RP between July 2013 and May 2014 were enrolled. Level of antibodies to GroEL and human Hsp60 was determined by enzyme-linked immunosorbent assay before surgery. Serum samples of blood donors with low reactivity to GroEL and human Hsp60 were used as controls. The relationship between IgG antibodies against bacterial Hsp60 and human Hsp60 and clinicopathological features were analyzed. The biochemical recurrence (BCR) free survival rate was estimated by the Kaplan — Meier method. The univariate and multivariate Cox regression models were used to evaluate the risk factors of BCR-free survival rate. Results: There were significant differences in anti-GroEL IgG levels between control and PCa patients while no significant differences in anti-human Hsp60 IgG levels between control and PCa patients were detected. During the follow-up period, 40/55 (72.7%) patients developed BCR. The time from surgery to BCR was from 18 to 72 months. Elevated IgG antibodies against bacterial Hsp60 in patients who had undergone RP were associated with early occurrence of biochemical relapse and lower 5-year BCR-free survival rate respectively (p < 0.001). The multivariate analysis indicated that IgG to GroEL (hazard ratio = 2.465; 95% confidence interval: 1.311–4.634, p < 0.05) could be independent prognostic factor in the patients who had developed BCR. Conclusion: Elevated levels of IgG antibodies against GroEL before surgery can predict early occurrence of BCR after RP and can serve as an additional independent risk biomarker of a BCR after RP.
EXPRESSION OF miRNA AS PROGNOSTIC MARKERS OF RENAL CELL CARCINOMA COURSE
Authors: Vitruk Yu. , Borikun T. , Rossylna O. , Zadvornyi T. , Semko S. , Voylenko O. , Stakhovsky O. , Shipko A. , Stakhovsky E. 
Published: January 2023

Renal cell carcinoma (RCC) is one of the most common solid tumors in adults. There is a lack of reliable prognostic and predictive biomarkers for RCC course. Dysregulation of miRNAs expression has been reported to be involved in RCC progression. However, the data on miRNAs expression patterns in tumors are controversial. Aim: To investigate the expression and clinical significance of miR-99b, -144, -155, -210, -222, -302а, -377 in RCC ex vivo. Materials and Methods: Retrospective analysis of the expression levels of miRNAs -99b, -144, -155, -210, -222, -302а, -377 in tumor tissue of 126 patients with clear cell RCC was performed using quantitative polymerase chain reaction. Results: Overexpression of miR-99b, -222, -302a and low levels of miR-155 in RCC tissues were significantly associated with advanced tumor stage (p < 0.05). In majority of patients with distant metastases (> 60%), high levels of miR-99b and 377 were detected (p < 0.05). High/low miR-99b, -144, -155, -210, -222, and -302a ratio was significantly associated with Fuhrman grade of tumors. Conclusion: Aberrant expression of miR-99b, -144, -155, -210, -222, -302а, -377 is strongly associated with advanced RCC, and panel of these miRNAs may be a useful prognostic marker for RCC course.
EXPRESSION OF CHEMOKINE (C-C MOTIF) RECEPTOR 7 IN PROSTATE CANCER TISSUE OF YOUNG PATIENTS AND IN METASTATIC CANCER CELLS
Authors: Parra-Medina R. , Payán-Gómez C. , Acosta-Vega N.L. , Ramírez-Clavijo S. 
Published: January 2023

Background: Chemokine (C-C motif) receptor 7 (CCR7) is a chemokine receptor involved in the carcinogenesis of several types of tumors due to its promoting action in epithelial-mesenchymal transition events, invasion, angiogenesis and metastasis. However, its role in prostate cancer (PCa) remains unclear. Aim: To evaluate CCR7 expression by immunohistochemistry in prostate tumors from young patients and to determine the possible relationship with the clinicopathological characteristics. Materials and Methods: We analyzed retrospectively paraffin-embedded tissue sections from 23 young PCa (≤ 55 years old) patients and evaluated the transcriptomic expression in the TCGA database. Results: Expression of CCR7 was observed in 15 cases (65%). The tissue samples from younger patients (≤ 50 years) were mostly positive in 72.7% (8/11) of cases. High grade GS (≥ 3) tumors were CCR7-positive in 71% cases. The malignant cells present in lymph nodes were CCR7 positive in 100% cases. The bioinformatic analysis showed a high CCR7 expression associated with the presence of metastasis (FC = 2.6, p = 0.03) in the Cancer Genome Atlas (TCGA) PCa cohort (PRAD). Conclusion: We showed that CCR7 expression in tumors from young patients is associated with the early onset of the disease and could also be related to lymph node metastasis.
SYNCHRONOUS HAIRY CELL LEUKEMIA AND HEPATOCELLULAR CARCINOMA: A CASE REPORT
Authors: Starchenko I.I. , Filenko B.M. , Royko N.V. , Kornilova I.V. , Vynnyk N.I. 
Published: January 2023

Multiple primary malignant tumors are characterized by independent occurrence and development of two or more malignant neoplasms in the same patient. We present an extremely rare case of synchronous double primary malignancies, hairy cell leukemia and hepatocellular carcinoma with lethal outcome. Diagnosis of hepatocellular carcinoma was difficult due to the presence of lymphoproliferative disease, which complicated the visualization of the process using ultrasonography. Carcinomatous emboli of hepatocellular carcinoma in small pulmonary arteries without the formation of metastatic foci have led to clinical manifestations typical of pulmonary embolism, pulmonary hypertension and severe respiratory failure. In lymphoproliferative diseases it is necessary to take into account the possibility of the development of another malignant neoplasm, which can be “buried” by tumor infiltration.
TREATMENT OPTION TO THE FERTILITY-SPARING RADICAL TRACHELECTOMY AFTER NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH CERVICAL CANCER WITH TUMOR SIZE >2CM
Authors: Shipko A. , Renkas O. , Svintsitskyi V. , Pryimak V. , Movchan O. 
Published: January 2023

Radical trachelectomy combined with pelvic lymphadenectomy (PLND) has been used to treat early stage cervical cancer patients who wish to preserve their fertility. But vaginal, abdominal, laparoscopic, and robotic approaches used for radical trachelectomy with pelvic PLND cause peritoneal damage, which could result in periadnexal adhesion. Here, we propose the neoadjuvant platinum based chemotherapy (NACT) with the vaginal radical trachelectomy with retroperitoneal PLND as a fertility-preserving option for early stage cervical cancer patients. VRT with retroperitoneal PLND was performed in three women with FIGO 2018 stage IB2 and IIA1 cervical cancers. In all three patients, complete response was achieved without causing any intraoperative and severe postoperative complications. NACT for fertility sparing treatment is an innovative approach, which is potentially quite interesting for many young women affected by cervical cancer with the tumor size >2 cm. Vaginal radical trachelectomy with retroperitoneal PLND can be safely performed and peritoneal damage, which can cause periadnexal adhesion, could be avoided. We consider that this surgical approach and NACT may be a good treatment option for women with cervical cancer who wish to preserve their fertility.
ROLE OF RADIOPROTECTORS IN MINIMIZATION OF STOCHASTIC EFFECTS OF RADIATION INCIDENTS
Authors: Domina E.A. , Kopylenko O.L. 
Published: January 2023

The real threat of emergency situations in Ukraine dictates the need to take into account the experience of previous radiation accidents, during which a significant part of the population was exposed to low-dose radiation. In such a case clinical manifestations of irradiation were mostly absent, while the danger of stochastic (carcinogenic) effects remained. Therefore, at present, the strategy of radiation protection of the population should be aimed at revising and choosing effective and low-toxic anti-radiation means. The main criterion for the development of stochastic consequences of exposure is radiation-induced genome instability, which is a promoter of carcinogenesis. The use of radiomitigators, which are able to weaken the harmful effect of ionizing radiation on critical highly radiosensitive systems of the human body, is promising. Our research showed the radiomitigative effect of inosine in cultured human T-lymphocytes on the genetic level with the significant decrease in the frequency of gamma-induced chromosome aberrations. The results experimentally justified an expediency of use of radiomitigators in the conditions of an emergency situation to minimize the occurrence and development of stochastic effects in population.