bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Promosi dan Harga terhadap Keputusan Pembelian pada E-Commerce Lazada Indonesia
Authors: Pranata Ismail Yogi Indra , Wahab Zakaria , Widiyanti Marlina , Rosa Aslamia 
Published: August 2023

Penelitian ini dilakukan bertujuan untuk mengetahui pengaruh promosi dan harga terhadap keputusan pembelian pada e-commerce Lazada Indonesia. Populasi dalam penelitian ini adalah seluruh konsumen yang melakukan pembelian pada Lazada Indonesia pada tahun 2021 dengan menggunakan teknik purposive sampling. Hasil dari analisis regresi linier berganda menunjukkan bahwa promosi berpengaruh positif dan signifikan terhadap keputusan pembelian pada e-commerce Lazada Indonesia. Harga berpengaruh positif dan signifikan terhadap keputusan pembelian pada e-commerce Lazada Indonesia. Pada variabel promosi, perlu adanya penambahan karyawan pada bagian customer service yang masih menjadi keluhan konsumen dalam menanggapi keluhan. Memberikan inovasi baru dalam program promosi yang lebih menarik seperti bekerja sama dengan bank-bank untuk memberikan potongan harga kepada konsumen jika melakukan pembayaran dengan menggunakan bank tertentu. Program gratis ongkos kirim yang diklaim semua untuk pengiriman seluruh Indonesia dengan menggunakan beberapa ekspedisi pengiriman. Pada variabel harga, sebaiknya pihak Lazada perlu adanya peninjauan kepada seller-seller yang berjualan pada e-commerce Lazada dalam penentuan harga. Untuk seller, jangan dibebankan biaya admin yang membuat harga produk menjadi lebih mahal. Selain itu perlu adanya peningkatan promosi untuk memberikan potongan harga yang lebih menarik untuk menjadikan daya tarik konsumen untuk melakukan pembelian.
Pengaruh Tata Kelola Perusahaan Terhadap Utang Perusahaan
Authors: Piettojo Jeremiah Jovan , Murhadi Werner R. , Wijaya Liliana Inggrit 
Published: August 2023

Penelitian ini bertujuan untuk menganalisis pengaruh tata kelola perusahaan yang mempengaruhi utang perusahaan. Variabel yang digunakan adalah dewan komisaris, komisaris indepen, kepemilikan institusi, ukuran perusahaan, usia perusahaan, dan profitabilitass. Penelitian ini menggunakan pendekatan kuantitatif dengan model analisis linier berganda. Penelitian ini menggunakan sampel berupa badan usaha industri manufaktur yang terdaftar di Bursa Efek Indonesia (BEI). Jumlah sampel yang digunakan adalah 260 observasi. Hasil temuan dari penelitian ini menunjukkan bahwa dewan komisaris, dan ukuran perusahaan berpengaruh positif signifikan terhadap leverage sementara komisaris indepen, kepemilikan institusi, usia perusahaan dan profitabilitass berpengaruh negatif signifikan terhadap leverage pada perusahaan industri manufaktur yang terdaftar di BEI
Career Anchor In The Concept Of Self-Employment Catholic High School Teacher
Authors: Meiliani Meiliani , Harmoko Yulius Paskalis , Christianti Oktarina 
Published: August 2023

Career anchors is strongly important to guide one’s internal career orientation that employ their talents/competent, motives/needs, and values in the various types of jobs, including teachers. The study aimed to describe the career anchors chosen by Catholic high schools’ teachers employed by Tarakanita fondation. Data were gathered from 302 teachers from 10 high schools and 2 colleges by distributing online survey questionnaires. A set of questionnaires was sent via emails directly to each teacher. Discriptive statistics of mean and percentage were applied to analisy the data gathered. The results showed that the highest rank of dominant career anchor was the economic security anchor, in contrary to it was supposed to be, that was the service anchor. None had multiple career anchors. It means that each teacher still focused on their basic needs in pursing her/his careers. This implies that either private or government individuals have the same career orientation in contrast to the original concept developed by Schein.
Incidência da tuberculose no estado de Sergipe entre 2017 e 2022: Um estudo epidemiológico
Authors: Santana Marcus Vinícius Mendes de 
Published: August 2023

Avaliar o perfil epidemiológico dos casos de Tuberculose em Sergipe entre 2017 e 2022. Trata-se de um estudo epidemiológico executado por meio dos dados disponibilizados pelo Departamento de Informática do Sistema Único de Saúde (DATASUS) por meio das informações colhidas através Sistema de Informação de Agravos de Notificação (SINAN). Os dados coletados foram armazenados e tabulados no Microsoft Office Excel®, de modo que fosse possível realizar frequência absoluta e relativa. Houve 5.730 casos de TB no período analisado em Sergipe, a maioria dos casos (n = 3.726) foram diagnosticados laboratorialmente, sendo que a maior prevalência foi no sexo masculino (73,6%) e em adultos jovens (60,73%). A TB pulmonar foi responsável por 88% dos casos, enquanto que os sítios mais comuns da extrapulmonar (10,4%) foram o pleural e o ganglionar. Alguns fatores de risco foram observados nos indivíduos com TB em Sergipe como tabagismo, uso de substâncias ilícitas e infecção pelo HIV. Ressalta-se que apenas 26,6% dos casos realizaram tratamento diretamente observado. Houve uma redução dos casos detectados durante o período da pandemia. O perfil da TB em Sergipe foi marcado por adultos jovens do sexo masculino, sendo encontrados fatores de risco como infecção por HIV e tabagismo. Uma limitação importante desse estudo foi o fato de haver um percentual importante de variáveis preenchidas como ignorado/branco.
AN ANALYSIS OF MOOD AND SPEECH FUNCTION IN THE TONIGHT SHOW STARRING JIMMY FALLON TALK SHOW
Authors: Nafalia Vina , Hartati Elysa 
Published: August 2023

This study aimed to find out the Interpersonal meaning that appeared in a conversation through the analysis of the Mood and speech function employed by the host and the guest star in The Tonight Show Starring Jimmy Fallon talk show. In analyzing the data, descriptive qualitative was used to interpret the data. The research findings showed that from the analysis, all of the Mood types were found in the conversation. The frequency of occurrence of types of Moods was 308 declarative, 11 interrogatives, and 5 imperatives. Meanwhile, there were only 3 speech functions out of 4 types of speech functions along with the responses employed by the host and the guest star. The data showed that the conversation was dominated by statements, followed by questions, and the last was command. Besides, both participants mostly responded to the interlocutor's statements by giving acknowledgment or contradiction. Both the host and the guest star were actively taking turns to initiate giving – a demanding exchange by adopting a speech role and assigning a complementary one to the other. It showed that understanding interpersonal communication was not enough by only analyzing the lexicogrammar of the Mood and speech function through the constructed clauses in any discourse, but more in how the language was able to make meaning and maintain a relationship
IMPROVING STUDENTS SPEAKING SKILLS THROUGH DEBATE STRATEGY
Authors: Ina timbu Maria Elisabeth , Bhoko Maria Lusia , Keli Eltrisna Wati 
Published: August 2023

In this research, the authors utilize the debate technique to improve students' speaking ability. The main goals of this study were to describe the implementation of the debate technique in teaching speaking and to identify how much the students' speaking ability was improved after being taught by using the debate technique. This study is classroom action research conducted in two cycles. Data were collected using observation, tests, and interviews. Data from observations, tests, and interviews taken from each cycle were analyzed quantitatively and qualitatively. The application of the debate technique in teaching speaking in class XI IPS 1 the high school in Maumere was conducted in two cycles, namely cycle one and cycle two. The participants of this study were 16 students. The result of this study shows that the use of debate techniques can improve students' speaking skills. This is evidenced by the students' test scores which have increased in each cycle. In the first cycle, the student’s average score was 54.37% and in the second cycle, the student’s average score was 69.37%. It can be inferred that the debate technique can increase students' interest in speaking and can also upgrade the class to be more favorable
The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli
Authors: Lee Beth S. , Murray Cynthia , Liu Jie , Kim Minji , Hwang Min Sik , Yueh Tina , Mansour Myrna , Qamar Sana , Agarwal Gunjan , Kim Do-Gyoon 
Published: August 2023

Introduction: Myosin IXB (MYO9B) is an unconventional myosin with RhoGAP activity and thus is a regulator of actin cytoskeletal organization. MYO9B was previously shown to be necessary for skeletal growth and health and to play a role in actin-based functions of both osteoblasts and osteoclasts. However, its role in responses to mechanical stimulation of bone cells has not yet been described. Therefore, experiments were undertaken to determine the role of MYO9B in bone cell responses to mechanical stress both in vitro and in vivo.Methods: MYO9B expression was knocked down in osteoblast and osteocyte cell lines using RNA interference and the resulting cells were subjected to mechanical stresses including cyclic tensile strain, fluid shear stress, and plating on different substrates (no substrate vs. monomeric or polymerized collagen type I). Osteocytic cells were also subjected to MYO9B regulation through Slit-Robo signaling. Further, wild-type or Myo9b−/− mice were subjected to a regimen of whole-body vibration (WBV) and changes in bone quality were assessed by micro-CT.Results: Unlike control cells, MYO9B-deficient osteoblastic cells subjected to uniaxial cyclic tensile strain were unable to orient their actin stress fibers perpendicular to the strain. Osteocytic cells in which MYO9B was knocked down exhibited elongated dendrites but were unable to respond normally to treatments that increase dendrite length such as fluid shear stress and Slit-Robo signaling. Osteocytic responses to mechanical stimuli were also found to be dependent on the polymerization state of collagen type I substrates. Wild-type mice responded to WBV with increased bone tissue mineral density values while Myo9b−/− mice responded with bone loss.Discussion: These results demonstrate that MYO9B plays a key role in mechanical stress-induced responses of bone cells in vitro and in vivo.
Natalizumab-immunogenicity evaluation in patients with infusion related events or disease exacerbations
Authors: Ciano-Petersen Nicolás Lundahl , Aliaga-Gaspar Pablo , Hurtado-Guerrero Isaac , Reyes Virginia , Rodriguez-Bada José Luis , Rodriguez-Traver Eva , Brichette-Mieg Isabel , Leyva Fernández Laura , Serrano-Castro Pedro , Alonso Ana , Oliver-Martos Begoña 
Published: August 2023

IntroductionNatalizumab is a biologic drug for relapsing-remitting multiple sclerosis that may induce the generation of anti-drug antibodies in some patients. Anti-natalizumab antibodies (ANA) increase the risk of adverse events and reduce efficacy, being useful biomarkers for monitoring treatment response.MethodsRetrospective observational study including MS patients treated with natalizumab that experienced infusion-related events (IRE) or disease exacerbations (DE). ANA were tested by Elisa including a screening and a confirmation assay. Patients were further classified as transient (one positive result) or persistent (two or more positive results) ANA.ResultsA total of 1251 MS patients were included and 153 (12.3%) had ANA with at least one single point determination, which were more frequent among patients with IRE compared to those with DE (21,6% vs.10.8%) during the first six infusions. Two or more determinations ANA were performed in 184 patients, being 31.5% permanently positive and 7.1% transiently positive. Interestingly, 26.1% of patients that experienced DE had persistent ANA, while 2.6% were transient. In contrast, 43% of patients with IRE had persistent ANA, and 9.3% had transient antibodies. Patients with persistent antibodies had more frequently high levels at the first sampling compared to patients with transient ANA.ConclusionReal-world evidence shows that the presence of ANA is behind an important percentage of patients treated with natalizumab that experience IRE, as well as DE but in a lower degree. These findings support the need to systematically evaluate ANA towards a personalized management of these patients to avoid undesired complications.
Clinical application of superselective transarterial embolization of renal tumors in zero ischaemia robotic-assisted laparoscopic partial nephrectomy
Authors: Li Haichang , Hu Yuning , Lu Dongning , Wang Jingyun , Lin Yanze , Zhong Xugang , Mou Yixuan , Yao Cenchao , Wang Zhida , Zhang Xinyu , Wo Qijun , Liu Hanbo , Liu Feng , Zhang Dahong , Wang Heng 
Published: August 2023

ObjectiveTo assess the feasibility and safety of zero ischaemia robotic-assisted laparoscopic partial nephrectomy (RALPN) after preoperative superselective transarterial embolization (STE) of T1 renal cancer.MethodsWe retrospectively analyzed the data of 32 patients who underwent zero ischaemia RALPN after STE and 140 patients who received standard robot-assisted laparoscopic partial nephrectomy (S-RALPN). In addition, we selected 35 patients treated with off-clamp RALPN (O-RALPN) from September 2017 to March 2022 for comparison. STE was performed by the same interventional practitioner, and zero ischaemia laparoscopic partial nephrectomy (LPN) was carried out by experienced surgeon 1-12 hours after STE. The intraoperative data and postoperative complications were recorded. The postoperative renal function, routine urine test, urinary Computed Tomography (CT), and preoperative and postoperative glomerular filtration rate (GFR) data were analyzed.ResultsAll operations were completed successfully. There were no cases of conversion to opening and no deaths. The renal arterial trunk was not blocked. No blood transfusions were needed. The mean operation time was 91.5 ± 34.28 minutes. The mean blood loss was 58.59 ± 54.11 ml. No recurrence or metastasis occurred.ConclusionFor patients with renal tumors, STE of renal tumors in zero ischaemia RALPN can preserve more renal function, and it provides a safe and feasible surgical method.
Evolving Project ECHO: delivery of pediatric pain core competency learning for interprofessional healthcare providers
Authors: Lalloo C. , Mohabir V. , Campbell F. , Sun N. , Klein S. , Tyrrell J. , Mesaroli G. , Stinson J. 
Published: August 2023

IntroductionHealthcare providers (HCPs) practicing in community settings are critical to improving access to pain care, yet there are significant gaps in training opportunities designed for interprofessional learners. Project Extension for Community Healthcare Outcomes (Project ECHO®) is an established model for delivering online HCP education through virtual clinics and cultivating a community of practice. However, to our knowledge, the integration of pain core competency education into the ECHO® model has not been previously attempted. This innovation could enhance the ECHO® model while also addressing the growing calls for more accessible interprofessional pain curricula. This paper describes efforts to implement and evaluate core competency curricula within the context of Pediatric Project ECHO for Pain, one of the first pediatric-pain focused ECHO programs in the world.MethodsNeeds assessments informed curricula development. The first delivered core competency model consisted of synchronous webinar-style sessions while the second model included a mixture of asynchronous (eLearning course) and synchronous (virtual clinical debrief) elements. A convenience sample of HCPs was recruited from ECHO program registrants. Participants completed baseline and follow-up surveys to assess core competency acceptability as well as impact on knowledge and self-efficacy related to managing pediatric pain. Usability of the eLearning platform (model 2 only) was also evaluated. Surveys used 5-point Likert scales to capture outcomes. A priori targets included mean scores ≥4/5 for acceptability and ≥80% of learners reporting knowledge and self-efficacy improvements. The study received local research ethics approval.ResultsThe core competency was found to be highly acceptable to interprofessional learners (n = 31) across delivery models, surpassing a priori targets. Specifically, it was characterized as a worthwhile and satisfactory experience that was helpful in supporting learning. The core competency was also associated with improvements in knowledge and self-efficacy by 97% and 90% of learners, respectively. The eLearning platform was reported to have high usability with clinically realistic cases (100% of respondents) that were helpful to inform care delivery (94% of respondents).ConclusionThe integration of core competency learning within the Project ECHO® model was a successful approach to deliver pediatric pain education to interprofessional HCPs.
Determinants of caregiver's knowledge and practices regarding childhood fever management in a developing setting: a multi-centre cross-sectional assessment
Authors: Ogunyinka Ibrahim A. , Oshikoya Kazeem A. , Yusuff Kazeem B. , Tahir Yusuf , Yahaya Mohammed , Adeniye Sulaiman B. , Oforkansi Innocent E. 
Published: August 2023

IntroductionFever is both a sign of various diseases (chief of which are infectious in nature) and an adverse effect of certain interventions (e.g. vaccines, drugs) in the pediatric population. It elicits anxiety among caregivers and healthcare professionals alike resulting in non-evidence based practices, adverse medication administration events, waste of scarce resources and overutilization of health facilities. The determinants of these practices among caregivers in the domiciliary contexts have not been well characterized in developing settings.MethodsWe assessed the knowledge and practices of childhood fever and their determinants among caregivers in domiciliary settings in Northern Nigeria using a 41-item questionnaire between August 2020 and February 2021.ResultsThe questionnaire is reliable (knowledge: Cronbach's Alpha = 0.689; practice: Cronbach's Alpha = 0.814) and collected data on a total of 2,400 caregiver-child pairs, who participated in the study. Over two-third (68.3%; 1,640) of the caregivers expressed fever phobic tendencies. Paracetamol was the most commonly used medication and constituted 31.3% of medication administration adverse events reported by the caregivers. Only one out of every six knowledgeable caregivers engaged in evidence-based home childhood fever management practices (7% vs. 41.6%) with being a primary caregiver [Knowledge: odd ratio (OR): 2.81, 95% CI: 0.38; 5.68; p value: 0.04; Practice: OR: 1.65, 95% CI: 0.09; 7.33; 0.02] and having a child/children aged ≤3 years (knowledge: OR: 7.03, 95% CI: 4.89; 9.67, p value: 0.003; practice OR: 3.11, 95% CI: 1.27; 8.59, 0.007) determining both the knowledge and practices of childhood fever management in a household.ConclusionsThe knowledge and practice of childhood fever management among caregivers were sub-optimal with being a primary caregiver and having a child/children aged ≤3 years being the significant determinants of each domain. These gaps underscore the dire need for targeted strategies aimed at improving childhood fever management by educating caregivers.
Outcomes of MIS-C patients treated with anakinra: a retrospective multicenter national study
Authors: Licciardi Francesco , Covizzi Carlotta , Dellepiane Marta , Olivini Nicole , Mastrolia Maria Vincenza , Lo Vecchio Andrea , Monno Viviana , Tardi Maria , Mauro Angela , Alessio Maria , Filocamo Giovanni , Cattalini Marco , Taddio Andrea , Caorsi Roberta , Marseglia Gian Luigi , La Torre Francesco , Campana Andrea , Simonini Gabriele , Ravelli Angelo , Montin Davide 
Published: August 2023

BackgroundThe treatment of multisystem inflammatory syndrome in children unresponsive to first-line therapies (IVIG and/or steroids) is challenging. The effectiveness of IL-1 receptor antagonist, anakinra, is debated.Patients and methodsWe conducted an anonymous retrospective multicenter study on MIS-C patients treated with anakinra in Italy from January 2020 to February 2021. Our study outcomes included the percentage of patients who required further therapeutic step-up, the percentage of patients who experienced fever resolution within 24 h and a reduction of CRP by half within 48 h, and the percentage of patients who developed Coronary Artery Anomalies (CAA) during follow-up.Results35 cases of MIS-C were treated in 10 hospitals. Of these, 13 patients started anakinra while in the ICU, and 22 patients started anakinra in other wards. 25 patients (71.4%) were treated with corticosteroids at a starting dose 2–30 mg/Kg/day plus IVIG (2 g/Kg), 10 patients (28.6%) received only corticosteroids without IVIG. Anakinra was administered intravenously to all patients in Group A (mean dose 8 mg/Kg/day), and subcutaneously in Group B (mean dose 4 mg/Kg/day). Only two patients required further treatment step-up and no patients developed CAA after receiving anakinra. The most commonly observed side effect was an increase in ALT, occurring in 17.1% of patients.ConclusionsIn this retrospective cohort of severe MIS-C patients treated with anakinra we report favorable clinical outcomes with a low incidence of side effects. The simultaneous use of steroids ± IVIG in these patients hinders definitive conclusions regarding the need of IL-1 inhibition in MIS-C treatment.
Posterior urethral hamartoma with hypospadias in a child: a case report and literature review
Authors: Hao Zipeng , Zhanghuang Chenghao , Zhang Kun , Hang Yu , Ji Fengming , Yan Bing , Tang Haoyu 
Published: August 2023

BackgroundHamartoma is a mass formed by the proliferation and disorder of two or more kinds of cells inherent in normal organs or anatomical parts, which can occur in any part of the body. The most common hamartoma are kidney hamartoma, spleen hamartoma, liver hamartoma, and lung hamartoma. Urethral hamartoma is extremely rare in clinical practice.Case reportCombined with literature review, the diagnosis and treatment process of a child with posterior urethral hamartoma and hypospadias in our hospital were analyzed. The patient was cured after surgical treatment, the lesion was completely removed, the appearance was satisfactory, and there was no recurrence, urethral stricture, urethral fistula, and other complications. The pathological results of this case support the histological diagnosis of hamartoma, which provides reference for the clinical diagnosis and treatment of congenital malformation and tumor of urogenital in children.ConclusionWhen a child has posterior urethral hamartoma, the symptoms may not be very typical, and it is often combined with urethral malformation. Therefore, it is necessary to perform careful physical examination combined with pathological examination to be able to make an accurate diagnosis. Under normal circumstances, the prognosis of urethral hamartoma is good. However, more cases are needed to be observed for verification, and a long-term effective follow-up after surgery is needed.