bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consequences of scarcity: the impact of perceived scarcity on executive functioning and its neural basis
Authors: Huang Long , Li Xiaojuan , Xu Fuming , Li Fuhong 
Published: June 2023

IntroductionPrevious studies have found a causal relationship between scarcity and the adverse impact it has on executive functioning. However, few studies have directly examined perceived scarcity, and cognitive flexibility (the third component of executive functions) has rarely been included.MethodsUsing a 2 (group: scarcity group vs. control group) × 2 (trial type: repeat trial vs. switch trial) mixed design, this study directly explored perceived scarcity’s impact on cognitive flexibility and revealed its neural basis in the switching tasks. Seventy college students participated in this study through open recruitment in China. A priming task was used to induce perceived scarcity, thus exploring the impact of perceived scarcity on participants’ performance in switching tasks and enabling the analysis of the neural activity of the brain, combined with electroencephalograph (EEG) technology.ResultsIn terms of behavioral outcomes, perceived scarcity led to poorer performance and a greater switching cost of reaction time in the switching tasks. Regarding neural activity, perceived scarcity led to an increase in the amplitude of P3 differential wave (repeat trials minus switch trials) in the parietal cortex during the target-locked epochs in the switching tasks.DiscussionPerceived scarcity can lead to changes in the neural activity of the brain regions related to executive functioning, resulting in a temporary decrease in cognitive flexibility. It may lead to individuals unable to adapt well to the changing environment, unable to quickly devote themselves to new tasks, and reduce work and learning efficiency in daily life.
A novel GRN mutation in an Italian patient with non-fluent variant of primary progressive aphasia at onset: a longitudinal case report
Authors: Castelnovo Veronica , Canu Elisa , Domi Teuta , Pozzi Laura , Vignaroli Francesca , Spinelli Edoardo Gioele , Ghirelli Alma , Tondo Giacomo , Comi Cristoforo , Riva Nilo , Quattrini Angelo , Carrera Paola , Filippi Massimo , Agosta Federica 
Published: June 2023

ObjectivesWe report the clinical presentation and evolution of a case with a novel Progranulin gene (GRN) mutation and non-fluent language disturbances at onset.Materials and methodsA 60 year-old, white patient was followed due to a history of language disturbances. Eighteen months after onset, the patient underwent FDG positron emission tomography (PET), and at month 24 was hospitalized to perform neuropsychological evaluation, brain 3 T MRI, lumbar puncture for cerebrospinal fluid (CSF) analysis, and genotyping. At month 31, the patient repeated the neuropsychological evaluation and brain MRI.ResultsAt onset the patient complained prominent language production difficulties, such as effortful speech and anomia. At month 18, FDG-PET showed left fronto-temporal and striatal hypometabolism. At month 24, the neuropsychological evaluation reported prevalent speech and comprehension deficits. Brain MRI reported left fronto-opercular and striatal atrophy, and left frontal periventricular white matter hyperintensities (WMHs). Increased CSF total tau level was observed. Genotyping revealed a new GRN c.1018delC (p.H340TfsX21) mutation. The patient received a diagnosis of non-fluent variant of primary progressive aphasia (nfvPPA). At month 31, language deficits worsened, together with attention and executive functions. The patient presented also with behavioral disturbances, and a progressive atrophy in the left frontal-opercular and temporo-mesial region.Discussion and conclusionThe new GRN p.H340TfsX21 mutation resulted in a case of nfvPPA characterized by fronto-temporal and striatal alterations, typical frontal asymmetric WMHs, and a fast progression toward a widespread cognitive and behavioral impairment, which reflects a frontotemporal lobar degeneration. Our findings extend the current knowledge of the phenotypic heterogeneity among GRN mutation carriers.
Towards unravelling biological mechanisms behind radiation-induced oral mucositis via mass spectrometry-based proteomics
Authors: Subedi Prabal , Huber Katharina , Sterr Christoph , Dietz Anne , Strasser Lukas , Kaestle Felix , Hauck Stefanie M. , Duchrow Lukas , Aldrian Christine , Monroy Ordonez Elsa Beatriz , Luka Benedikt , Thomsen Andreas R. , Henke Michael , Gomolka Maria , Rößler Ute , Azimzadeh Omid , Moertl Simone , Hornhardt Sabine 
Published: June 2023

ObjectiveHead and neck cancer (HNC) accounts for almost 890,000 new cases per year. Radiotherapy (RT) is used to treat the majority of these patients. A common side-effect of RT is the onset of oral mucositis, which decreases the quality of life and represents the major dose-limiting factor in RT. To understand the origin of oral mucositis, the biological mechanisms post-ionizing radiation (IR) need to be clarified. Such knowledge is valuable to develop new treatment targets for oral mucositis and markers for the early identification of “at-risk” patients.MethodsPrimary keratinocytes from healthy volunteers were biopsied, irradiated in vitro (0 and 6 Gy), and subjected to mass spectrometry-based analyses 96 h after irradiation. Web-based tools were used to predict triggered biological pathways. The results were validated in the OKF6 cell culture model. Immunoblotting and mRNA validation was performed and cytokines present in cell culture media post-IR were quantified.ResultsMass spectrometry-based proteomics identified 5879 proteins in primary keratinocytes and 4597 proteins in OKF6 cells. Amongst them, 212 proteins in primary keratinocytes and 169 proteins in OKF6 cells were differentially abundant 96 h after 6 Gy irradiation compared to sham-irradiated controls. In silico pathway enrichment analysis predicted interferon (IFN) response and DNA strand elongation pathways as mostly affected pathways in both cell systems. Immunoblot validations showed a decrease in minichromosome maintenance (MCM) complex proteins 2-7 and an increase in IFN-associated proteins STAT1 and ISG15. In line with affected IFN signalling, mRNA levels of IFNβ and interleukin 6 (IL-6) increased significantly following irradiation and also levels of secreted IL-1β, IL-6, IP-10, and ISG15 were elevated.ConclusionThis study has investigated biological mechanisms in keratinocytes post-in vitro ionizing radiation. A common radiation signature in keratinocytes was identified. The role of IFN response in keratinocytes along with increased levels of pro-inflammatory cytokines and proteins could hint towards a possible mechanism for oral mucositis.
Beyond the known phenotype of sotos syndrome: a 31-individuals cohort study
Authors: Lourdes Vega-Hanna , Mario Sanz-Cuesta , Didac Casas-Alba , Mercè Bolasell , Loreto Martorell , Leticia Pías , Lucia Feller Ana , Martínez-Monseny Antonio Federico , Mercedes Serrano 
Published: June 2023

IntroductionSotos Syndrome (SS, OMIM#117550) is a heterogeneous genetic condition, recognized by three main clinical features present in most cases: overgrowth with macrocephaly, typical facial appearance and different degrees of intellectual disability. Three different types are described caused by variants or deletions/duplications in NSD1, NFIX and APC2 genes. We aimed to describe a cohort of pediatric patients reporting the typical and unexpected findings in order to expand the phenotype of this syndrome and trying to find genotype-phenotype correlations.MethodsIn our referral center, we collected and analyzed clinical and genetic data of 31-patients cohort diagnosed with SS.ResultsAll of them presented with overgrowth, typical dysmorphic features and different degree of developmental delay. Although structural cardiac defects have been reported in SS, non-structural diseases such as pericarditis were outstanding in our cohort. Moreover, we described here novel oncological malignancies not previously linked to SS such as splenic hamartoma, retinal melanocytoma and acute lymphocytic leukemia. Finally, five patients suffered from recurrent onychocryptosis that required surgical procedures, as an unreported prevalent medical condition.DiscussionThis is the first study focusing on multiple atypical symptoms in SS at the time that revisits the spectrum of clinical and molecular basis of this heterogeneous entity trying to unravel a genotype-phenotype correlation.
Efficacy and safety of inclisiran in stroke or cerebrovascular disease prevention: a systematic review and meta-analysis of randomized controlled trials
Authors: Luo Min , Liu Yihan , Xu Xinyi , Liu Kai , Shen Chao , Hu Haoyang , He Zhiyao , Wu Fengbo 
Published: June 2023

Aims: As the impact of inclisiran in stroke prevention in atherosclerotic cardiovascular disease (ASCVD) patients or those at high risk of ASCVD is still unclear, we conducted a systematic review and meta-analysis of randomized controlled trials (RCT) to quantify the effectiveness of inclisiran in stroke prevention in these patients.Methods: Literature research was conducted in four electronic databases (PubMed, EMBASE, Web of Science, CENTRAL) and two clinical trials registers (ClinicalTrials.gov, WHO ICTRP) from the inception of the study to 17 October 2022, and was updated by the end of the study on 5 January 2023. Two authors independently screened the studies, extracted the data, and assessed the bias. The risk of bias was assessed using the Cochrane risk-of-bias tool for randomized trials (RoB 2). The intervention effect was estimated by calculating risk ratio (RR), weighted mean difference (WMD), and 95% confidence interval (CI) with R 4.0.5. Sensitivity analysis by changing meta-analysis model was also performed to test the robustness of the pooled results. If this was not possible, a descriptive analysis was conducted.Results: Four RCTs (n = 3,713 patients) were rated as high-risk bias. Meta-analysis of three RCTs (ORION-9, ORION-10, and ORION-11) showed that inclisiran reduced myocardial infarction (MI) risk by 32% (RR = 0.68, 95%CI = 0.48–0.96) but did not reduce stroke (RR = 0.92, 95%CI = 0.54–1.58) and major cardiovascular events (MACE) (RR = 0.81, 95%CI = 0.65–1.02) risk. Sensitivity analysis results were stable. Safety was similar to the placebo group but had frequent injection-site reactions (RR = 6.56, 95%CI = 3.83–11.25), which were predominantly mild or moderate. A descriptive analysis of one RCT (ORION-5) was conducted due to different study designs, and suggested that inclisiran might be given semiannually from the beginning.Conclusion: Inclisiran is not beneficial for stroke or MACE prevention in ASCVD or patients at high risk of ASCVD but is associated with the reduction of MI. Given the limited number and quality of the available studies and the lack of a standardized definition for cardiovascular events, further studies are essential for confirming the results.
Effect of rubbing symmetry on polarization distribution in ferroelectric nematic liquid crystal cells
Authors: Kamifuji Hirokazu , Nakajima Kazuma , Tsukamoto Yuji , Ozaki Masanori , Kikuchi Hirotsugu 
Published: June 2023

Abstract
It is a significant issue in controlling the polarization distribution in ferroelectric nematic liquid crystal cells. We investigated the polarization configuration of ferroelectric nematic liquid crystals on the surface and in the bulk of parallel/anti-parallel cells with rubbed substrates and proposed the polarization models in each cell. It is found that on the surface of rubbed polyimide films, the polarization direction is fixed and opposite to the rubbing direction. Splay and twist distribution of the polarization are formed in parallel and anti-parallel cells, respectively.
Sapta Setia Darma
Authors: Sapta Setia Darma  
Published: June 2023

Penelitian ini bertujuan membuktikan bahwa Self Assessment System, Tarif Pajak dan Keadilan terhadap tindakan tax evasion. Jenis Penelitian ini adalah deskriptif kuantitatif. Populasi pada penelitian ini adalah wajib pajak Umkm yang terdaftar di KPP Pratama Serpong. Teknik pengambilan sampel dengan menggunakan probability sampling dalam memilih sampel maka diperoleh jumlah sampel 100 responden. Hasil penelitian diolah menggunakan teknik analisis regresi linier berganda dengan dibantu oleh program aplikasi komputer SPSS Statistic For Windows 23.Hasil penelitian menunjukan bahwa self assessment system memiliki pengaruh positif signifikan terhadap tindakan tax evasion, tarif pajak memiliki pengaruh negative terhadap tindakan tax evasion dan keadilan tidak memiliki pengaruh terhadap tindakan tax evasion.
Communication and Social Interaction across Cultures: The Case of a German and Ghanaian Educational Exchange Program
Authors: Alhassan Abdul-Razak Kuyini , Abdulai Muhammed , Ibrahim Hadi 
Published: June 2023

Using a constructivist epistemology, this paper explores the cross-cultural learning experiences of exchange students from Hochschule Düsseldorf University of Applied Sciences in Germany and the University for Development Studies in Ghana. The findings reveal differences in the students’ commitment to agreements, tasks and time; while the German students have a high commitment to time awareness -- reporting to lectures and other meetings on time -- their Ghanaian counterparts do not. We suggest that universities preparing students for educational exchange programs should actively embark on cross-cultural education and training, providing adequate information on the context and culture of the host country, targeting all stakeholders before, during and after the exchange program. This will enhance effective intercultural relations and social interaction, and minimize culture shock.
Identifikasi Konsentrasi Siswa Di SMAN 10 Batang Hari
Authors: Melisa Defri 
Published: June 2023

Tujuan Penelitian: Penelitian ini adalah untuk dapat mendeskripsikan konsentrasi belajar siswa di sekolah menengah yang berlokasi di distrik Batang Hari bertepatan di SMA 10 di Batanghari
Metodologi: Metode yang digunakan adalah metode kuantitatif dengan jenis survei ini. Sampel yang digunakan adalah 121 siswa, dengan teknik pengambilan data adalah total sampling. Instrumen penelitian yang digunakan adalah kuesioner dengan analisis data adalah analisis deskriptif dengan menggunakan mean, median dan mode.
Main Findings: Hasil yang diperoleh berdasarkan indikator yang ada dalam pembelajaran konsentrasi cukup baik.
Analisis Lingkungan Belajar Siswa Mata Pelajaran Fisika di Sekolah Menengah Atas Negeri 10 Kota Jambi
Authors: Ramil Evi Rahma 
Published: June 2023

Tujuan penelitian: Penelitian ini bertujuan untuk mengetahui lingkungan belajar siswa terhadap fisika di SMAN 10 kota Jambi
Metodologi: Jenis penelitian ini adalah instrumen kuantitatif yang digunakan adalah kuesioner. Subjek penelitian ini adalah 97 siswa di SMAN 10 kota Jambi. Teknik analisis data kuantitatif menggunakan statistik deskriptif
Temuan Utama: Hasil dari empat indikator yang dibahas dalam penelitian ini, indikator pada metode pengajaran fisika sebanyak 64,9% kategori baik. Untuk indikator hubungan guru fisika dengan 43,2% siswa dikategorikan baik. Kemudian pada indikator standar pembelajaran fisika sekolah terhadap 35% kategori baik. Sedangkan pada indikator tugas rumah terhadap fisika sebanyak 42,2% siswa dikategorikan cukup.
Hubungan Hasil Belajar terhadap Prestasi Belajar Siswa Kelas XI
Authors: Nurmadanti Tiara 
Published: June 2023

Tujuan Penelitian: Untuk mengetahui hubungan antara minat belajar fisika dengan hasil belajar fisika di kelas XI MIPA di SMAN 3 Sungai Penuh.
Metodologi: Peneliti mengambil sampel sebanyak 61 siswa yang mana siswa tersebut adalah siswa dari kelas XI MIPA 1, XI MIPA 2, dan XI MIPA 3. Teknik analisis data yang digunakan adalah analisis deskriptif dan inferensial. Metode pengumpulan data menggunakan angket dan tes soal yaitu angket minat belajar fisika dan tes soal fisika mengenai elastisitas dan hukum hooke.
Temuan Utama: Ada hubungan antara minat belajar dengan prestasi belajar fisika siswa. Hal ini dilihat dari perolehan nilai Uji korelasi yang dipeeroleh pearson correlation sebesar 0,873 dan nilai Sig. (2-tailed) sebesar 0,000.
Keterbaruan/Keaslian dari Penelitian: mengetahui apakah hasil belajar berhubungan dengan minat siswa.
Analisis Sikap Dan Minat Siswa terhadap Pembelajaran Fisika di SMA
Authors: Susanti Irma 
Published: June 2023

Tujuan Penelitian: Tujuan penelitian ini adalah untuk mengetahui sikap dan minat terhadap mata pelajaran fisika di SMA NEGERI 8 MUARO JAMBI berdasarkan penilaian sikap TOSRA (Test of Science Related Attitudes).
Metodologi: Penelitian ini menggunakan google foarm. Subjek penelitian adalah siswa kelas XII IPA di SMA Negeri 8 Muaro Jambi yang berjumlah 60 siswa. Metode yang digunakan yaitu dengan menyebar angket menggunakan google foarm kepada siswa. Jenis penelitian ini adalah kualitatif kuantitatif yang menggunakan prosedur penelitian yaitu rancangan penelitian survei. Instrumen yang digunakan adalah angket dengan teknik analisis data yaitu descriptive statistic untuk data kuantitatif menggunakan statistik deskriptif.
Temuan Utama: Hasil dari 2 indikator yang ditentukan pada tulisan ini adalah indikator dari sikap yaitu 60% siswa berkategori cukup baik. Indikator minat siswa yaitu 40% berkategori cukup baik.
Keterbaruan/Keaslian dari Penelitian: Sebelum pembelajaran fisika dimulai, diharapkan guru fisika menyiapkan dan memperhatikan terlebih dahulu seperti ruang, manejemen waktu, serta sarana dan prasarana agar proses pembelajaran bisa terlaksana dengan baik.
Analisis Pendidikan Karakter “Motivasi” Belajar Siswa Kelas X SMAN 1 Kota Jambi
Authors: Pratiwi Maharani Rizky , Ramadhanti Auliya , Setyarini Endah Febri , Kholila Kholila , Fitriani Riska 
Published: June 2023

Tujuan Penelitian: Untuk membandingkan hasil ketiga kelas tersebut dan melihat tingkat motivasi belajar siswa di SMA Negeri 1 Kota Jambi dalam proses pembelajaran.
Metodologi: Penelitian ini menggunakan jenis penelitian survey dengan instrumen penilaian tes berupa angket dengan variable karakter motivasi belajar, dan menggunakan metode penelitian kuantitatif deskriptif. Penelitian ini bertujuan untuk menganalisis karakter siswa, khususnya karakter motivasi belajar siswa kelas X SMAN 1 Kota Jambi. Subjek penelitian ini adalah siswa kelas X MIA 4, X MIA 5 dan X MIA 6 SMAN 1 Kota Jambi, dengan jumlah total responden sebanyak 90 responden. Teknik pengambilan sampel menggunakan total sampling yaitu jumlah sampel sama dengan populasi.
Temuan Utama: Angket motivasi belajar siswa kelas X MIA 4 rata-rata tergolong dalam kategori “Cukup Baik” dengan 70 % pernyataan dijawab setuju oleh siswa dan 30 % pernyataan dijawab dengan sangat setuju oleh siswa. Hasil penelitian pada kelas X MIA 5 rata-rata tergolong dalam kategori “Baik” dengan 60 % pernyataan dijawab setuju oleh siswa dan 40 %, dijawab sangat setuju oleh siswa. Sedangkan hasil penelitian pada kelas X MIA 6 rata-rata tergolong dalam kategori “Lebih Baik” dengan 43,3 % pernyataan dijawab setuju oleh siswa dan 56,7 %, dijawab sangat setuju oleh siswa. Berdasarkan hasil angket tersebut, dapat disimpulkan bahwa tingkat motivasi belajar siswa kelas X MIA 4 lebih rendah dari kelas X MIA 5 dan X MIA 6.
Keterbaruan/Keaslian dari Penelitian: Melihat tingkat motivasi belajar siswa.
Pengaruh Minat Belajar Siswa terhadap Hasil Belajar Fisika di SMA Negeri 1 Bungo
Authors: Nurmadanti Tiara 
Published: June 2023

Tujuan Penelitian: Untuk mengukur sejauh mana minat siswa SMA Negeri 1 Bungo terhadap fisika.
Metodologi: Metode yang digunakan adalah metode penelitian studi kasus dengan pendekatan kualitatif. Pengumpulan data dilakukan dengan memberikan angket kepada siswa dan pengolahan data dilakukan dengan menggunakan teknik model Analisis Interaktif. Kemudian membuat persentase dari hasil angket siswa tersebut.
Temuan Utama: Hasil analisis data, siswa kelas X MIPA SMA Negeri 1 Bungo memiliki minat terhadap fisika dengan skor rata-rata 91,6%. Berdasarkan hasil analisis menunjukkan bahwa siswa SMA Negeri 1 Bungo memiliki minat terhadap fisika.
Keterbaruan/Keaslian dari Penelitian: Penelitian tentang analisis minat belajar siswa terhadap mata pelajaran fisika di SMA Negeri 1 Bungo bertujuan untuk mengukur sejauh mana minat siswa SMA Negeri 1 Bungo terhadap mata pelajaran fisika.
Identifikasi Minat Siswa dalam Mata Pelajaran FisiIdentifikasi Minat Siswa dalam Mata Pelajaran Fisika pada Kelas X MIPA SMAN 1 Muaro Jambika pada Kelas X MIPA SMAN 1 Muaro Jambi
Authors: Wicaksono Langgeng Yoga , Aldila Febri Tia , Yusmanita Fera 
Published: June 2023

Tujuan Penelitian: Untuk mengidentifikasi tentang minat siswa kelas X MIPA di SMA Negeri 1 Muaro Jambi terhadap mata pelajaran fisika.
Metodologi: Penelitian yang dilakukan ini menggunakan metode deskriptif dengan pendekatan kuantitatif. Untuk memperoleh data yang digunakan dalam penelitian ini maka digunakan lembar instrumen observasi berupa angket yang berisi pernyataan-pernyataan mengenai minat terhadap pelajaran fisika.
Temuan Utama: 27 orang atau sekitar 54% dari siswa sampel ternyata masih memiliki minat yang kurang terhadap mata pelajaran fisika, sedangkan 23 orang atau sekitar 46% dari sampel sisanya cukup meminati mata pelajaran fisika
Keterbaruan/Keaslian dari Penelitian: mengidentifikasi minat belajar siswa pada mata pelajaran fisika.
Analisis Motivasi Belajar Siswa pada Pelajaran Fisika Kelas XI IPA di SMA Negeri 6 Kota Jambi
Authors: Salmawati Salmawati , Oktavia Widia Dina 
Published: June 2023

Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui tingkat Motivasi belajar siswa terhadap pelajaran fisika di SMA Negeri 6 Kota Jambi.
Metodologi: Pada penelitian ini menggunakan teknik pengumpulan data penelitian kuantitatif berupa kuisioner atau angket yang dilakukansecara online melalui google form.
Temuan Utama: Siswa kelas XI IPA SMA Negeri 6 Kota Jambi rata-rata 56,3333% lebih sering termotivasi pada saat pelajaran fisika.
Keterbaruan/Keaslian dari Penelitian
On local properties of singular integral
Authors: Mamedkhanov J. I. , Jafarov S. Z. 
Published: June 2023

UDC 517.5 Letγbe a regular curve. We study the local properties of singular integrals in the Hαα+β(t0,γ)class of functions. We obtain a strengthening of the Plemelj\–Privalov theorem for functions from the classHαα+β(t0,γ). It is proved that, at the pointt0,of increased smoothness for α+β<1,there is only a logarithmic loss.
Legendre superconvergent degenerate kernel and Nyström methods for nonlinear integral equations
Authors: Allouch C. , Arrai M. , Bouda H. , Tahrichi M. 
Published: June 2023

UDC 517.9

We study polynomially based superconvergent collocation methods for the approximation of solutions of nonlinear integral equations. The superconvergent degenerate kernel method is chosen for approximating the solutions of Hammerstein equations, while a superconvergent Nystr\"om method is used for solving Urysohn equations. By applying interpolatory projections based on Legendre polynomials of degree

≤
n
,

we analyze the superconvergence of these methods and their iterated versions. Numerical results are presented to validate the theoretical results.