bluuebunny/crossref_metadata_2025_split huggingface dataset:
LMK235 ameliorates ventricular remodelling after myocardial infarction by targeting cardiac fibroblasts and macrophages
Authors: Fangzhou Lv 
Published: March 2023

Abstract
Objectives Histone deacetylase 4 (HDAC4)and histone deacetylase 5 (HDAC5) are two isoforms of class IIa HDACs, LMK235 is an HDAC inhibitor with higher selectivity forHDAC4/5. Here, we aimed to explorethe effects of LMK235 on ventricular remodelling after myocardial infarction (MI).
Methods The MI model was established by left anterior descending branch ligation. The effects of LMK235 on cardiac dysfunction was determined by echocardiography and left ventricular pressure measurement. Fibrosis was evaluated by Masson staining and fibrotic biomarker expression, inflammation was evaluated by HE staining and inflammatory cytokine expression. In vitro, myofibroblast transformation was induced by transforming growth factor-β1 (TGF-β1) stimulation in primary mouse cardiac fibroblasts (MCFs), and macrophage polarization was induced by lipopolysaccharide (LPS) stimulation in RAW264.7 cells. Western blotting, immunofluorescence, flow cytometry were performed to examine the effects of LMK235.
Key findings LMK235 ameliorated cardiac dysfunction post-MI by suppressing fibrosisand inflammation. In MCFs, LMK235 attenuated TGF-β1-induced fibrotic biomarker expression by inhibiting Smad2/3 pathway. In RAW264.7 cells, LMK235 attenuated LPS-induced inflammatory cytokine expression by inhibiting NF-κB pathway.
Conclusions LMK235 can attenuate fibrosis post-MI by inhibiting Smad2/3 pathway in cardiac fibroblasts, and attenuate inflammation post-MI by inhibiting NF-κB pathway in macrophages, leading to improved cardiac function.
Magnitude and time course of urinary iodine excretion in relation to thyroid function in patients on amiodarone therapy
Authors: Pinto Giuseppe , Marchionni Giulia , Locatelli Massimo , Foppoli Luca , Monaca Giuseppe , Fragasso Gabriele 
Published: March 2023

Abstract
Purpose. Amiodarone is a source of excess iodine that may induce thyroid dysfunction. The aim of the present analysis was to evaluate the magnitude and time course of 24-hr urinary iodine excretion and its potential relationship with thyroid disorders in patients on antiarrhythmic prophylaxis with amiodarone.
Methods. 24-hr urinary iodine excretion and thyroid function were evaluated in 67 patients on chronic amiodarone therapy. All patients were clinically and biochemically euthyroid before starting treatment and were followed up by 6-month measurements of 24-hr urinary iodine excretion and plasma TSH levels.
Results. Since amiodarone initiation, 20 patients developed thyroid dysfunction (14 hypothyroidism, 3 subclinical hypothyroidism, 3 hyperthyroidism). No differences were observed in terms of treatment length or urinary iodine levels between patients remaining euthyroid and those developing thyroid dysfunction: urinary iodine in the euthyroid group was 8094 µg/24h (IQR 4082-10766) vs 10851 µg/24h (IQR 8529-12804) in the thyroid dysfunction group at 6 months (p = 0.176) and 8651 µg/24h (IQR 6924-11574) vs 8551 µg/24h([IQR 4916-13580) (p = 0.886) at one year from amiodarone initiation. The occurrence of thyroid dysfunction was equally distributed among patients taking amiodarone for more than one year versus those under treatment for less than one year. Upon amiodarone withdrawal, normal range of urinary iodine was achieved after a mean time of 15.2 ± 7.7 months.
Conclusion. These results suggest no correlation between 24-hr urinary iodine excretion and thyroid dysfunction in patients on amiodarone therapy. Thyroid disorders following amiodarone administration likely depend on the individual predisposition to iodine load.
Economic feasibility analysis of using serum C-reactive protein as a screening tool for high-risk people with diabetes complications in the community: an empirical analysis using CHARLS data
Authors: Wu Qian , Wang Bing , Yang Xiaohong , Gao Li , Wang Yujia , Chen Chunli , Peng Yaqin , Cheng Fang , Cai Wenjun 
Published: March 2023

Abstract
Objectives: To explore the economic feasibility of using serum C-reactive protein as a screening tool for groups at high risk of diabetes-related complications in Chinese communities.
Methods: In this study, we use data from China Health and Retirement Longitudinal Survey (CHARLS) in 2015. Thenthe Markov model was used to explore the economic feasibility of using serum C-reactive protein as a screening tool for high-risk groups of diabetic complications in Chinese communities.
Results: In our study，27.8% of patients with serum C-reactive protein were at high risk. According to the Markov, it predict that using serum C-reactive as a screening tool for high risk groups of diabetes will reduce the economic burden by ¥50,350.01 per individual compared with the control group . According to the current population proportion of diabetes in China, it estimate that will reduce the economic burden by ¥5840.6 billion（$837.58 billion）,the mortality rate by 8.3% , and the incidence rate of myocardial infarction by 42.2% in five years .This is equivalent to saving 9.628 million lives of diabetes patients and reducing myocardial infarction events by 48.72 million and the economic burden by ¥3134.84 billion ($449.6 billion).
Conclusions: In this study, It is economically feasible to use serum C-reactive protein as a screening tool for high risk groups of diabetes complications in the China community.
Cement Kiln Dust in CIMENCAM Figuil (North Cameroon): characteristics and recycling as additives for blended cement production
Authors: KANOUO Sylvestre Nguo , TOUMBA Hamadou , DIKWA Jerome , Tchamba Arlin Bruno 
Published: March 2023

Abstract
This work presents the manufacture of CKD-blended cement from raw materials such as clinker, gypsum, marble and cement kiln dust (CKD) obtained from CIMENCAM Figuil, North Region of Cameroon. The raw materials were first characterized through XRF and physical properties such as fineness, consistency, setting time, and expansion were determined from the cement paste. Clinker is composed of CaO (65.30 %) and SiO2 (21.13%), with significant MgO (2.71%) Na2O+K2O (1.29%), SO3 (0.81 %) and lime saturation factor (LSF) of (97.9); which make this clinker good for cement production. Gypsum is composed of SO3 (36.32 %) and CaO (33.92 %) but contains very low proportion of impurities; it is therefore classified as low-impurities gypsum suitable for cement productions. The marble is dominantly composed of CaO (37.09 %) with significant SiO2 (7.26 %), SO3(2.40%), (2.36 %), Fe2O3 (1.82 %) and MgO (0.18 %); it is classified as low-CaO calcitic-aluminosilicate and ironsilicate bearing marble. The cement kiln dust (CKD) is dominantly made up of CaO (46.0 %) and SiO2 (11.62 %) with significantly low Na2O+ K2O (1.02 %), and SO3(2.16 %); this classifies its as low alkalies-sulfate cement kiln dust. CKD-blended cements which contains free lime (0.8-2.5, SO3 (above 1.7 to 2.5), loss on ignition (LOI), and insoluble residues (6.71-9.62 %) which increase with an increase in the proportion of CKD. The blaine specific surface area (BSSA) (4797-6346 cm2/g) and the sieved remaining proportion (26.14-30.36 %) show an increase with the proportion of used CKD;
The compressive strength test was carried out at 2, 7, 28 days which shows that, the resistance depends on the proportion of the used CKD (0% control, 5%, 10%, 15%, 20%... up to 50%). Pressures of 17.5 to 11.6 MPa was obtained in 2 days, 28.9 to 20.0 Mpa in 7 days, and 35.5 to 23.3 Mpa in 28 days.
Improving the quality assessment of drilled
holes in aircraft structures
Authors: Kawano Frederico Leoni Franco , Toledo Claudio Fabiano Motta , Barbosa Gustavo Franco , Sagawa Juliana Keiko , Shiki Sidney Bruce 
Published: March 2023

Abstract
This paper presents a case study carried out in an assembly cell where automated drilling of an aeronautical structure is performed. The study shows how techniques approached by the 4.0 industry have the potential to contribute to manufacturing, breaking the limits imposed by the previous state of the art systems. This paper proposes a method capable of calculating an indicator for the final quality of the drilled holes, by using a committee of neural networks, which analyses data obtained by monitoring the electric current consumed by the drilling system drive. The method has the potential to enhance the efficiency of the drilling process, avoiding measurement steps and physical inspections that increases the cell cycle time.The proposal contributes to the literature by presenting an unprecedented application and to the praxis by solving a relevant problem of the aerospace industry.
FAIR-ification of structured Head and Neck Cancer clinical data for multi-institutional collaboration and federated learning
Authors: Gouthamchand Varsha , Choudhury Ananya , Hoebers Frank , Wesseling Frederik , Welch Mattea , Kim Sejin , Kazmierska Joanna , Dekker Andre , Haibe-Kains Benjamin , Soest Johan , Wee Leonard 
Published: March 2023

Abstract
Federated learning has been demonstrated as an acceptable clinical research methodology for producing analyses and models on dispersed datasets, without the need for exchanging individual patient-level data. Attention needs to be given to making repositories of clinical data Findable, Accessible, Interoperable and Reusable (FAIR) in order to realize the potential of such clinical data in federated learning applications. This work draws attention to FAIR-ification structured clinical data of Head and Neck cancer patients, generated in different parts of the world with incompatible terminologies. We began with an “open world” approach by converting the native datasets into the Resource Descriptor Framework format, and then applying a customized local annotation for each dataset to map the data fields to open access ontologies. This approach allows interactive data exploration by means of a federated SPARQL query-based dashboard. The annotations and dashboard visualizations were constructed without using the individual patient-level data. It is feasible to develop and validate multi-institutional statistical models with federated learning on top of the annotations that make the data FAIR. Findings are robust and potentially scalable to a larger number of participating institutions. The annotation methodology proposed here supports multiple simultaneous mappings (such as the data being re-used in multiple different projects) while keeping the native data the same. Future work may be to include certain rules and requirements for classes and predicates, and using the Shapes Constraint Language for checking the validity of the data.
Thermal dependent ferroelectric Cochran’s frequency and dielectric properties in arsenate type family of KDP crystal
Authors: Kuldeep Kuldeep Kumar , Trilok Trilok Chandra Upadhyay 
Published: March 2023

Abstract
Phonon anharmonic interactions up to the fourth order, and four body interaction terms, with the consideration of the extra spin-lattice term, direct spin-spin interaction terms, and four spin coupling are introduced into the earlier modified Ising type of pseudo-spin model Hamiltonian to account for the investigation of dielectric properties in arsenate type family of KDP crystals. Cochran’s mode frequency and other ferroelectric properties like energy shift, and width, electrical permittivity, spontaneous polarization, and loss tangent are investigated, in the vicinity of 𝑇𝑐. We have expressed the equation of Dyson and decoupled the correlation function with the consideration of Zubarev’s statistical article and two-time temperature-dependent Green’s function approach to deduct the theoretical derivation of the above ferroelectric parameter. Thermal variations of <𝑆𝑥> and <𝑆𝑧> order parameters are also introduced here, which is responsible for the first-order phase transition phenomenon. A comparison of theoretical findings has been made with experimental findings reported by earlier authors. Good agreement is observed for the investigation of the above ferroelectric properties in CsH2AsO4, RbH2AsO4, and KH2AsO4, crystals.
A New Proposal for High Contrast Ratio All-Optical 4 × 2 Encoder Using 2D Photonic Crystals
Authors: Parandin Fariborz , Chimawi Gailan Irfan Kareem 
Published: March 2023

Abstract
Optical encoders are widely used circuits that are used in digital circuits. One of the most critical features of an optical encoder is the power values in two logic states, low and high. The difference between these two values is expressed with the Contrast Ratio (CR) parameter. In this research, an optical encoder with four inputs and two outputs based on a two-dimensional photonic crystal has been designed and simulated. The results show that the proposed structure has low power in low mode and high intensity in high mode. This difference in two logical modes has caused the proposed encoder to have CR = 19.8dB, which is improved compared to previous works. Also, the proposed structure has a very small size, equal to 96.88 µm2. This encoder can be used in optical integrated circuits with low error according to the obtained values.
Evaluation of meteorological drought effects on underground water level fluctuations using data mining methods (case study: semi-deep wells of Golestan province)
Authors: Roshan Ameneh , Ghorbani Khalil , Salarijazi Meysam , Oskouei Ebrahim Asadi 
Published: March 2023

Abstract
In most arid and semiarid environments, groundwater is one of the precious resources threatened by water table decline and desiccation, thus it must be constantly monitored. Identifying the causes influencing the variations of the subsurface water level, such as meteorological drought, is one approach for monitoring these fluctuations. In the present study, the effect of two meteorological drought indices SPI and SPEI on the fluctuations of the underground water level was evaluated, as was their relationship with the drought index of the subsurface water level (SWI) using multivariate linear regression and M5 decision tree regression. After calculating climatic and hydrological drought indicators in a 6-month time window for a long-term statistical period (1989–2018), the semi-deep aquifers of Golestan province, which is located in northern Iran, were considered as a research location for this purpose. The results demonstrated that the effect of meteorological drought does not immeddergiately manifest in the changes of the subsurface water table and the hydrological drought index. By adding the meteorological drought index with a 6-month lag step, the average air temperature, and the total rainfall from the previous 6 months as new variables, the correlation with the SWI index increases, so that in the best-case scenario, the M5 decision tree model provides the best result in predicting the SWI index. The second half of the year yielded a coefficient of determination of 0.92 and an error value of RMSE = 0.27 for the SPEI index. Among the meteorological drought indicators, the SPEI index, which is based on precipitation and evapotranspiration, created a stronger link with the SWI index, which highlights the significance of potential evapotranspiration. It is a warning that, as a result of global warming, subsurface water tables in this region may fall in the future.
Pseudoalteromonas epidermidis sp. nov. isolated from skin of bandtail puffer fish (Sphoeroides spengleri)
Authors: Mattsson Hannah , Freitas Mayanne , Azevedo Gustavo P. R. , Arruda Tatiane , Salazar Vinicius , Tschoeke Diogo A. , Thompson Cristiane C. 
Published: March 2023

AbstractThis manuscript provides the description of the bacterial strain designated A520T(A520T= CBAS 737T= CAIM 1944T) characterized by Gram-negative, flagellated, aerobic bacteria. It was obtained from the skin of the bandtail pufferfishSphoeroides spengleri(Tetraodontidae Family), collected in Arraial do Cabo, located in the Rio de Janeiro region, Brazil. Optimum growth occurs at 25 - 30 °C in the presence of 3% NaCl. The genome sequence of the novel isolate consisted of 4.502 Mb (4,082 coding genes and G+C content of 41.1%). The closest phylogenetic neighbor wasPseudoalteromonas shioyasakiensisJCM 18891T (94.8% Average Amino Acid Identity and 51.8% Genome-to-Genome-Distance) and several in silico phenotypic features are useful to differentiate the proposed new species,Pseudoalteromonas epidermidissp. nov., from its closest phylogenetic neighbors, including Acetate utilization, Sucrose, L-Arabinose, L-Rhamnose and Gas from glucose. The genome of the novel species also contains 3 gene clusters (~66.81 Kbp in total) coding for different types of bioactive compounds that may account to several possible ecological roles in the bandtail pufferfish host.
Integration Battery Energy Storage Using T- Type Solid State Transformer Based Multilevel Inverter
Authors: Molli Krishna , P Ajay D Vimal Raj 
Published: March 2023

Abstract
Storage technologies are essential for preserving the renewable grid power balance between generation and consumption. In this research, a solid-state transformer (SST) based T-type multilevel inverter (MLI) is proposed for the medium/high voltage integration of large-scale battery energy storage (BES). For any turn ratio, the proposed SST-MLI generates 25 levels with fewer switching devices and SSTs. A novel dynamic phase shift controller (NDPSC) is also being developed for the proposed BES system. The NDPSC controller regulates active and reactive power by maintaining the battery's health. The NDPSC controller uses two gain control factors tuned to produce a fast response without overshooting. The proposed battery storage system's dynamic behavior is simulated in MATLAB/Simulink for various active and reactive power variations and experimentally validated in a low-power laboratory prototype system.
FICZ activating AHR protects against intestinal injury in mice with DSS-induced colitis by regulating intestinal flora and metabolism
Authors: Yin Liping , Jiang Linxin , Zhou Ziyang , Zhao Jinying , Tang Jianguo , Wang Zetian 
Published: March 2023

Abstract
Background: Aromatic hydrocarbon receptors (AHR) are widely expressed in the intestinal barrier and play a regulatory role in intestinal inflammation and immunity.
Objectives: In this study, a dextran sulfate (DSS)-induced colitis mouse model was established to detect the effects of AHR activation on the intestinal barrier, flora, and metabolites.
Design: The mice were randomly divided into three groups: Control group, DSS group, and DSS- formylindole (3,2-b) carbazole (FICZ) group. The Control group accepted sterile distilled water, the DSS group received 3%DSS, and the DSS-FICZ group were provided 3% of DSS and intraperitoneal injection of FICZ (1ug / mouse / day).
Methods: The mental state and the fecal traits were observed, the basic living characteristic occult blood and inflammatory cytokine levels in the serum were detected. Fecal samples were collected for gut microbiota and metabolite analysis by 16S rRNA gene sequencing and LC–MS metabolomics.
Results: AHR activation significantly improved the degree of colon shortening in DSS-induced colitis mice, reduced the degree of intestinal mucosal barrier damage, the production of inflammatory factors, and the intestinal epithelial permeability, and increased the tight junction protein expression. The results of 16S rRNA gene sequencing found that, compared with the DSS group, the abundance of Desulfobacterota was up-regulated in the DSS-FICZ group, and the abundance of Proteobacteria was down-regulated at the phylum level. At the genus level, Escherichia-Shigella was down-regulated, Clostridia _ UCG-014, Alistipes, andParabacteroides were up-regulated. At the species level, Escherichia _ coli _ g _ Escherichia-Shigella，Bacteroides _ sartorii _ g _ Bacteroides，Paeniclostridium _ sordellii _ g _ Paeniclostridium and Clostridium _ perfringens _ g _ Clostridium _ sensu _ stricto _ 1 were down-regulated; Bacteroides _ dorei _ g _ Bacteroides was up-regulated, Helicobacter _ hepaticus _ g _ Helicobacter, and Bacteroides _ caecimuris _ g _ Bacteroides was up-regulated, Parabacteroides _ distasonis _ g _ Parabacteroides were down-regulated. LC-MS metabolomics detection revealed that there were differences in a variety of intestinal contents between DSS group and DSS-FICZ group, which was mainly related to histidine metabolism, arginine biosynthesis, lysine degradation, and steroid biosynthesis.
Conclusion: The activation of AHR can protect against intestinal injury in mice with DSS-induced colitis by regulating intestinal flora and metabolism.
A proposal for an operational methodology to assist the ranking-aggregation problem in manufacturing
Authors: Franceschini Fiorenzo , Maisano Domenico A. , Mastrogiacomo Luca 
Published: March 2023

Abstract

Ranking aggregation is an ancient problem with some characteristic elements: a number of experts, who individually rank a set of objects according to a certain (subjective) attribute, and the need to aggregate the resulting expert rankings into a collective judgment. Although this problem is traditionally very popular in fields such as social choice, psychometrics, and economics, it can also have several interesting applications in manufacturing, e.g., for customer-oriented design, reliability engineering, production management, etc. Through a case study related to cobot-assisted manual (dis)assembly, the paper illustrates an operational methodology and various useful tools that assist in tackling the problem practically, effectively, and with a critical mind. The most relevant proposed tools assist in estimating the degree of concordanceamong experts, the collective judgment’s consistency and robustness. The paper is aimed at scientists and practitioners in manufacturing.
Roles of human periodontal ligament stem cells in osteogenesis and inflammation in periodontitis models: effect of 1α,25-dihydroxyvitamin D 3
Authors: Wang Jing-jiao , Zhang Cheng-lei , Guo Xiao-qian , Yang Chang-yi 
Published: March 2023

AbstractPeriodontitis is a chronic inflammatory disease caused byPorphyromonas gingivalisand other bacteria, and human periodontal ligament stem cells (hPDLSCs) are a promising candidate for the treatment of periodontal supporting tissue defects. This study aimed to investigate the effect of 1α,25-dihydroxyvitamin D3[1,25(OH)2VitD3] on osteogenic differentiation of hPDLSCs in anin vitroperiodontitis model and whether it can improve inflammatory status. hPDLSCs werein vitroisolated and identified. After treatment with 1,25(OH)2VitD3and ultrapure purePorphyromonas gingivalislipopolysaccharide (LPS-G), the viability of hPDLSCs was detected using Cell Counting Kit-8, the expressions of osteogenic markers and inflammatory genes using Western blotting and quantitative reverse transcription PCR (qRT-PCR), the levels of inflammatory factors in cells using enzyme linked immunosorbent assay (ELISA), and the fluorescence signal intensity of osteoblastic markers and inflammatory genes in cells using immunofluorescence assay. It was found that 1,25(OH)2VitD3reversed the inhibition of hPDLSCs proliferation by LPS-G; LPS-G exhibited inhibitory effect on ALP, Runx2, and OPN expressions, and such inhibitory effect was significantly weakened when co-acting with 1,25(OH)2VitD3. Meanwhile, LPS-G upregulated the expressions of inflammatory genes IL-1β and Casp1, whereas 1,25(OH)2VitD3antagonized such an effect and improved the inflammatory status. In conclusion, 1,25(OH)2VitD3can reverse the inhibitory effect of LPS-G on hPDLSCs proliferation and osteogenic differentiation and suppress LPS-G-induced upregulation of inflammatory gene expressions.