bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conducting international online surveys: Trials, tribulations, and suggestions for success
Authors: Zanchetta Margareth , Metersky Kateryna , Medeiros Marcelo , Santos Walterlânia Silva , Mésenge Christian , Lessa Moussa Issa 
Published: January 2023

<p>In the context of the need for the production of knowledge in low-and middle-income countries, as well as in high-income countries with their socially vulnerable populations and the concomitant, minimal availability of funding for international research, university researchers should innovate. This paper discusses critical methodological issues in the process of designing and implementing international online survey research. This is done in the context of responding to the need for innovation in the research methodology and research design in the field of global health. The focus is ondata collection instrumentation to expand their responsiveness to the international field and the participants’ characteristics. The chapter is organized with the presentation of online international research, first presenting insights for an alternative and innovative design, then formulating questions to remotely collect international data highlighting survey methods, renewing a dialogue setting, and exploring issues of recruitment, attrition,and participation. It also reports successful experiences of the internationalization of research, intellectual partnerships,and shared successes in the process of creating, exchanging,and translating knowledge in the context of global health and the democratization of knowledge. The experiences are related to qualitative inspired research implemented in the continental sphere (Africa, South and North America, and Europe) with the creation of survey questionnaires for an exploration of narratives, experiences, and decisions. The mobilization of researchers’ social and professional networks, in addition to the constant reformulation of intellectual partnerships in research, istoday the most common strategies to face the current challenges in academia. Innovation for methodological advances in audacious design for unpredictable fieldwork may require the revisiting of epistemological grounds. Emerging issues in this type of research, such as “research fatigue”, should be considered.</p>
Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease
Authors: G. Sugiyama Michael , Cui Haotian , Redka Dar’ya
S. , Karimzadeh Mehran , Rujas Edurne , Maan Hassaan , Hayat Sikander , Cheung Kyle , Misra Rahul , McPhee Joseph , Viirre Russell , Haller Andrew , Botelho Roberto , Karshafian Raffi , Sabatinos Sarah , Fairn Gregory D. , Tonekaboni Seyed Ali Madani , Windemuth Andreas , Julien Jean-Philippe , Shahani Vijay , MacKinnon Stephen S. , Wang Bo , N. Antonescu Costin 
Published: January 2023

<p>The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronaviruses cause diseases ranging from severe respiratory infections to the common cold. We developed a computational approach to identify new antiviral drug targets and repurpose clinically-relevant drug compounds for the treatment of a range of human coronavirus diseases. Our approach is based on graph convolutional networks (GCN) and involves multiscale host-virus interactome analysis coupled to off-target drug predictions. Cell-based experimental assessment reveals several clinically-relevant drug repurposing candidates predicted by the in silico analyses to have antiviral activity against human coronavirus infection. In particular, we identify the MET inhibitor capmatinib as having potent and broad antiviral activity against several coronaviruses in a MET-independent manner, as well as novel roles for host cell proteins such as IRAK1/4 in supporting human coronavirus infection, which can inform further drug discovery studies.</p>
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Path Analysis Pengaruh Norma Subjektif dan Persepsi terhadap Perilaku Donor Darah Plasma Konvalesen
Authors: Astuti Yuli - 
Published: January 2023

Corona Virus Disease 2019 (Covid-19) merupakan salah satu penyakit menular yang muncul pertama di Wuhan Cina. Pandemi Covid-19 masuk di Indonesia mulai awal tahun 2020. Plasma konvalesen merupakan salah satu terapi pengobatan yang direkomendasikan untuk penanganan Covid-19 yang mengalami manifestasi klinis yang berat. Perilaku donor plasma konvalesen dipengaruhi oleh banyak faktor yang diperantarai oleh niat donor. Tujuan penelitian ini adalah untuk mengetahui path analysis faktor yang mempengaruhi perilaku donor darah plasma konvalesen. Metode Penelitian ini merupakan penelitian dengan metode observasional analitik, dengan teknik pengumpulan datanya adalah data primer dengan kuisioner dibagikan kepada 39 responden secara acidental sampling. Uji statistik yang digunakan adalah analisis jalur dengan aplikasi SPSS 21. Hasil Penelitian ini terdapat pengaruh signifikan norma subjektif terhadap niat dan perilaku donor (P<0.005); terdapat pengaruh signifikan persepsi terhadap niat dan perilaku donor (P<0.005), dan terdapat pengaruh signifikan norma subjektif dan persepsi terhadap perilaku donor melalui niat donor darah plasma konvalesen (β1=-0.317, β2=0.396; e1=0.718; e2=0.488). Kesimpulan Terdapat pengaruh signifikan norma subjektif terhadap niat donor darah plasma konvalesen, terdapat pengaruh signifikan persepsi terhadap niat donor darah plasma konvalesen, dan terdapat pengaruh signifikan norma subjektif, serta persepsi terhadap perilaku donor darah plasma konvalesen melalui niat berdonor darah plasma konvalesen.
Profil Pengobatan Dispepsia Pasien Rawat Inap di RSUD Budhi Asih periode Juli 2019 – Juni 2020
Authors: Sitompul Fransiska - , Hidayat Dwikarlina , Kurniaty Linggom , Muraga Nadya Theresia 
Published: January 2023

Dispepsia merupakan sekumpulan gejala yang menimbulkan sensasi tidak nyaman di bagian saluran pencernaan, umumnya dirasakan di daerah epigastrium, antara bagian bawah prosessus xiphoideus sampai dengan umbillicus. Istilah dispepsia berasal dari bahasa yunani, terdiri dari 2 suku kata yaitu (“dys” artinya buruk ; “pepsis” artinya pencernaan). Sekumpulan gejala klinis yang dapat dirasakan antara lain seperti sensasi terbakar dan nyeri epigastrium, mual, muntah, kembung, penumpukan gas di epigastrium, kekenyangan dan sendawa. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan pengobatan dispepsia pasien rawat inap di RSUD Budhi Asih periode Juli 2019 – Juni 2022. Penelitian ini dilakukan dengan desain cross sectional retrospektif. Sampel terdiri dari 139 rekam medik pasien dispepsia diambil secara total sampling. Hasil penelitian diperoleh dispepsia dialami perempuan (58,99%), keluhan utama mual (74,82%), terapi obat antiulkus: sucralfate oral (25,77%), dan terapi prokinetik : ondansetron (33,73%), lama rawat 1-3 hari (71,22%), variasi jumlah obat dispepsia dan anti ulkus menunjukkan jumlah obat 1-3 (92,81%), bentuk sediaan obat injeksi (50,34%), dan bentuk tablet (26,68%). Kesimpulan penelitian adalah faktor yang berhubungan dengan pengobatan dispepsia pasien rawat inap di RSUD Budhi Asih periode Juli 2019 – Juni 2022 dipengaruhi jenis kelamin, gejala klinis yang dikeluhkan, kelas terapi antikulkus, variasi jumlah obat dan bentuk sediaan obat.
Peningkatan Pengetahuan 1000 Hari Pertama Kehidupan pada Calon Pengantin Melalui Promosi Kesehatan
Authors: Fadhilah Nurul , Agustina Agustina 
Published: January 2023

Pengetahuan 1000 Hari Pertama Kehidupan (HPK) penting diberikan kepada calon pengantin untuk mencegah terjadinya Kekurangan Energi Kronis (KEK) pada ibu hamil yang merupakan penyebab langsung kematian ibu. Namun berdasarkan beberapa penelitian terdahulu didapatkan hasil bahwa pengetahuan calon pengantin mengenai 1000 HPK masih tergolong kurang. Tujuan penelitian untuk mengetahui perbedaan dan pengaruh promosi kesehatan terhadap pengetahuan 1000 HPK yang meliputi konsep 1000 HPK, periode kehamilan, periode anak 0-6 bulan, dan periode anak 6-24 bulan pada calon pengantin di Kantor Urusan Agama (KUA) Kecamatan Pancoran. Penelitian ini menggunakan metode kuantitatif dengan desain studi pra-eksperimental. Penelitian dilakukan pada Maret-Juni 2022 di KUA Kecamatan Pancoran dengan populasi penelitian calon pengantin yang mendaftar di KUA Kecamatan Pancoran, jumlah sampel penelitian sebanyak 84 responden. Teknik pengumpulan data yaitu accidental sampling, dengan instrumen penelitian berupa kuesioner. Pelaksanaan promosi kesehatan dilakukan dengan metode komunikasi interpersonal dengan media leaflet. Data dianalisis dengan uji univariat dan uji bivariat. Hasil analisis bivariat dengan uji Wilcoxon didapatkan adanya pengaruh promosi kesehatan 1000 HPK (p=0,000), periode kehamilan (p=0,000), periode anak 0-6 bulan (p=0,000), dan periode anak 6-24 bulan (p=0,000) dengan peningkatan pengetahuan calon pengantin mengenai 1000 HPK. Penelitian ini menyimpulkan terdapat perbedaan dan pengaruh pengetahuan 1000 HPK secara signifikan sebelum dan sesudah pemberian promosi kesehatan pada calon pengantin. Diharapkan KUA Kecamatan Pancoran menambahkan materi mengenai 1000 HPK pada saat kelas calon pengantin (Catin) agar calon pengantin dapat mempersiapkan dengan baik kesehatan pada masa 1000 HPK.
Analisis Efektivitas Biaya Pelayanan Sectio Caesarea: Studi Kasus pada Masa Sebelum dan Saat Pandemi COVID-19 di Rumah Sakit X Tahun 2019-2020
Authors: Abdullah Muhammad Raoul Taufiq 
Published: January 2023

Pandemi COVID-19 membuat seluruh interaksi tatap muka menjadi terhambat, termasuk pelayanan sectio caesarea. Perkumpulan Obstetri dan Ginekologi Indonesia (POGI) telah membuat sebuah pedoman pelayanan persalinan yang beradaptasi dengan masa pandemi COVID-19. Pedoman terbaru menambahkan prosedur skrining COVID-19 pratindakan, pengadaan APD, dan sterilisasi ketat alat serta ruangan. Hal ini berpotensi untuk meningkatkan biaya dan mengurangi efisiensi pelayanan SC. Peneliti melakukan penelitian pada Rumah Sakit X dengan menggunakan data sekunder pasien tindakan SC dengan rentang waktu Juni-Desember 2019 sebagai kelompok sebelum pandemi dan Juni-Desember 2020 sebagai kelompok pada saat pandemi. Hasil penelitian menunjukkan adanya peningkatan pengeluaran per pasien yang signifikan dibandingkan pada masa sebelum pandemi. Hal ini tidak diikuti dengan penambahan pendapatan per pasien sehingga berdampak pada penurunan profit per pasien yang signifikan. Kelompok sampel pada saat pandemi juga tidak menunjukan adanya peningkatan Length of Stay (LoS) yang signifikan sebagai luaran persalinan. Peneliti menggunakan analisis ACER dan ICER untuk menentukan efektivitas layanan secara keseluruhan. Hasil perhitungan menunjukan bahwa ACER pada masa pandemi lebih tinggi secara signifikan dibandingkan dengan sebelum pandemi. Hasil perhitungan mendapatkan juga nilai ICER sebesar -Rp426.940,77 per hari. Kedua nilai ini dapat menujukan bahwa prosedur tindakan SC pada saat pandemi tidak efektif dari segi biaya. Sehingga peneliti memiliki kesimpulan bahwa standar operasional prosedur tindakan SC selama masa pandemi COVID-19 tidak cost-effective jika dibandingkan dengan masa sebelum pandemi COVID-19.
Pengembangan Bahan Ajar Model Discovery Learning Menggunakan Media Digital di SMA N 1 Terbanggi Besar
Authors: Umihani Umihani , Nurwahidin Muhammad , Pujianti Pujianti , Riswandi Riswandi 
Published: January 2023

Guru sebagai motor penggerak dan pelaksana dalam pembelajaran peserta didik, dituntut harus memiliki kemampuan dalam menciptakan, mengembangkan, melaksanakan dan mengevaluasi setiap proses belajar mengajar didalam kelas. kurangnya variasi media pembelajaran yang menarik menyebabkan siswa merasa bosan dan pembelajaran terkesan monoton sehingga pada akhirnya siswa tidak fokus dalam belajar. Penelitian ini bertujuan untuk mengetahui efektivitas. pengembangan bahan ajar model discovery learning dengan menggunakan media digital di SMA Negeri 1 Terbanggi Besar. Metode Penelitian ini adalah penelitian kuanititatif, jenis penelitian ini adalah penelitian quasi-experiment dengan menggunakan hasil pretest dan posttest. Populasi yang digunakan yaitu peserta didik kelas XI IPS yang berjumlah 30 orang peserta didik. Hasil penelitian diketahui efektivitas bahan ajar model discovery learning dengan menggunakan media digital Dapat dikatakan cukup efektif digunakan sebagai media pembelajaran di SMA Negeri 1 Terbanggi Besar. Dengan hasil perhitungan diatas diketahui nilai pretest dan posttest, diperoleh nilai skor N Gain sebesar 0,64 dengan kategori sedang sedangkan nilai persentase 64,00% dengan tafsiran Cukup Efektif.
Perancangan Buku Fotografi Esai "Hygge" untuk Menarik Minat Wisatawan dan Masyarakat di Kota Malang
Authors: Yosephine Tiffany , Nugroho Didit Prasetyo 
Published: January 2023

Munculnya berbagai macam kafe di Kota Malang menimbulkan gaya hidup baru yaitu berkumpul bersama teman khususnya bagi generasi muda. Gaya hidup ini membuat kafe terus bermunculan di Kota Malang dengan konsep yang disukai oleh generasi ini, salah satunya yaitu konsep cozy. Tetapi hal ini membuat kafe yang terus bermunculan kurang memperhatikan kualitas dari segi suasana dan menu karena terlalu berfokus dengan interior cozy yang disukai generasi muda. Maka dari itu dibutuhkan media informasi yang bisa menarik wisatawan dan masyarakat dalam memilih dan mengunjungi kafe bukan hanya berdasarkan tren, melalui pembuatan perancangan yang bertujuan mendapatkan visualisasi konsep melalui media buku fotografi esai yang memuat informasi tentang 8 kafe dengan konsep cozy di Kota Malang. Metode perancangan yang digunakan yaitu metode perancangan komunikasi kreatif serta dipadukan dengan metode pengumpulan data kualitatif. Buku fotografi esai ini menggunakan gaya foto interior dan makanan, dengan ukuran buku 22,4 x 17 cm dengan total 248 halaman, full color, serta dijilid menggunakan hardcover laminasi doff. Kesimpulan perancangan ini adalah mendapatkan visualisasi konsep buku fotografi esai untuk memberikan informasi tentang kafe cozy melalui visualisasi foto yang diserta narasi melalui media buku dan media pendukung seperti bookmark, tote bag, photo sheet, sticker, tumbler, acrylic straw, diffuser, dan media pemasaran melalui sosial media Instagram.
The consumption and reggaeton´s language under debate among adolescents
Authors: González Gómez Isabel , Delgado-García Manuel 
Published: January 2023

Music is not just a simple pastime, as it also contributes to the construction of identities, promotes cultural development or generates close affective ties between those who share the same musical preferences. In recent years, reggaeton has become very popular, a musical genre admired by youth and characterized by containing, in its lyrics, discriminatory messages towards women. In this sense, it is vitally important to question the impact exerted on adolescents, where it has penetrated with greater impetus, analyzing the possible consequences that it may have when building or reinforcing macho thoughts.
A qualitative research is proposed that tries to examine the perceptions of adolescents. Through two focus groups, the opinions of young people enrolled in the educational stages of 2nd ESO and 3rd ESO from two secondary education institutes in the province of Huelva are debated and confronted. During the focus group sessions, the participants question the relationship between different variables that emerge from the properties of the language used in some reggaeton lyrics, such as machismo or gender violence. The analysis of the speeches derived from the work sessions has been developed through the Maxqda software.
The results reveal a type of music that is expanding as a trend among adolescents, whose messages are not clearly discriminated or prosecuted and which tend to normalize certain discriminatory behaviors towards women and reinforce macho thinking among the male gender. For all these reasons, the educational system must promote the creation of a musical culture that invites adolescents to be aware of and critically judge the music they listen to daily.
Effect of collagen cross-linkers on dentin bond strength: A systematic review and network meta-analysis
Authors: Chen Huan , Sun Guangdi , Wang Huimin , Yu Shiyang , Tian Zilu , Zhu Song 
Published: January 2023

Objective: This study aimed to evaluate the role of collagen cross-linkers in the bonding performance of the resin-dentin interface through a systematic review and a network meta-analysis.Sources: The literature search was conducted in several databases like PubMed, EMBASE, Cochrane, Scopus and Web of Science from their inception till 30 April 2022.Study selection: The inclusion criteria consisted of in vitro studies evaluating the micro-tensile and micro-shear bond strengths of different cross-linkers acting on dentin. Bayesian network meta-analysis was conducted using RStudio.Data: Out of the 294 studies evaluated in the full-text analysis, 40 were included in the systematic review and meta-analysis. Most studies have used cross-linkers as primer (65.1%), followed by incorporating them into in adhesives and acid etching agents. The application methods of the adhesive system were classified as “etch-and-rinse (ER) adhesives” (77%) and “self-etching (SE) adhesives”. Moreover, there were six types of cross-linkers in this presented review, of which the most numerous were polyphenols.Conclusion: Different application methods of cross-linkers, the long-term results showed that were only effective when used for longer durations, the immediate results were not statistically different. According to immediate and long-term results, etch-and-rinse (ER) adhesives showed a greater bonding performance than the control groups (p ≤ 0.05), whereas self-etching (SE) adhesives showed similar bond strength values (p ≥ 0.05). The result of network meta-analysis (NMA) showed that Dope like compound showed higher long-term bonding performance than other cross-linkers.Clinical significance: Long-term clinical studies may be needed to determine the effect of the cross-linkers on the bonding properties.
Research progress of exosomes in pathogenesis, diagnosis, and treatment of ocular diseases
Authors: Feng Xinting , Peng Zhen , Yuan Lingyi , Jin Ming , Hu Haijian , Peng Xin , Wang Yaohua , Zhang Chun , Luo Zhiwen , Liao Hongfei 
Published: January 2023

Exosomes are natural extracellular vesicles with a diameter of 30–150 nm, which exist in biological fluids and contain biomolecules related to the parent cell, such as proteins, nucleic acids, lipids, etc. It has a wide range of biological functions, and participates in the regulation of important physiological and pathological activities of the body. It can be used as a biomarker for early diagnosis of ocular diseases, a potential therapeutic target, a targeted drug carrier, and has a high potential for clinical application. In this paper, we summarized the genesis mechanism, biological functions, research and application progress of exosomes, focused on the engineering strategy of exosomes, and summarized the advantages and disadvantages of common engineering exosome preparation methods. Systematically combed the role of exosomes in corneal diseases, glaucoma, and retinal diseases, to provide a reference for further understanding of the role of exosomes in the pathogenesis, diagnosis, and treatment of ocular diseases. Finally, we further summarized the opportunities and challenges of exosomes for precision medicine. The extension of exosome research to the field of ophthalmology will help advance current diagnostic and therapeutic methods. Tiny exosomes have huge potential.
Electrochemically stable tunnel-type α-MnO2-based cathode materials for rechargeable aqueous zinc-ion batteries
Authors: De Luna Yannis , Alsulaiti Asma , Ahmad Mohammad I. , Nimir Hassan , Bensalah Nasr 
Published: January 2023

The purpose of this study is the synthesis of α-MnO2-based cathode materials for rechargeable aqueous zinc ion batteries by hydrothermal method using KMnO4 and MnSO4 as starting materials. The aim is to improve the understanding of Zn2+ insertion/de-insertion mechanisms. The as-prepared solid compounds were characterized by spectroscopy and microscopy techniques. X-ray diffraction showed that the hydrothermal reaction forms α-MnO2 and Ce4+-inserted MnO2 structures. Raman spectroscopy confirmed the formation of α-MnO2 with hexagonal MnO2 and Ce-MnO2 structures. Scanning electron microscopy (SEM) confirmed the formation of nanostructured MnO2 (nanofibers) and Ce-MnO2 (nanorods). The electrochemical performance of MnO2 was evaluated using cyclic voltammetry (CV), galvanostatic charge-discharge (GCD) tests in half-cells. CV results showed the reversible insertion/de-insertion of Zn2+ ions in MnO2 and Ce-MnO2. GCD cycling tests of MnO2 and Ce-MnO2 at 2500 mA/g demonstrated an impressive electrochemical performance, excellent cycling stability throughout 500 cycles, and high rate capability. The excellent electrochemical performance and the good cycling stability of MnO2 and Ce-MnO2 nanostructures by simple method makes them promising cathode materials for aqueous rechargeable zinc-ion batteries.
Pre-epidemic evolution of the MRSA USA300 clade and a molecular key for classification
Authors: Bianco Colleen M. , Moustafa Ahmed M. , O’Brien Kelsey , Martin Michael A. , Read Timothy D. , Kreiswirth Barry N. , Planet Paul J. 
Published: January 2023

IntroductionUSA300 has remained the dominant community and healthcare associated methicillin-resistant Staphylococcus aureus (MRSA) clone in the United States and in northern South America for at least the past 20 years. In this time, it has experienced epidemic spread in both of these locations. However, its pre-epidemic evolutionary history and origins are incompletely understood. Large sequencing databases, such as NCBI, PATRIC, and Staphopia, contain clues to the early evolution of USA300 in the form of sequenced genomes of USA300 isolates that are representative of lineages that diverged prior to the establishment of the South American epidemic (SAE) clade and North American epidemic (NAE) clade. In addition, historical isolates collected prior to the emergence of epidemics can help reconstruct early events in the history of this lineage.MethodsHere, we take advantage of the accrued, publicly available data, as well as two newly sequenced pre-epidemic historical isolates from 1996, and a very early diverging ACME-negative NAE genome, to understand the pre-epidemic evolution of USA300. We use database mining techniques to emphasize genomes similar to pre-epidemic isolates, with the goal of reconstructing the early molecular evolution of the USA300 lineage.ResultsPhylogenetic analysis with these genomes confirms that the NAE and SAE USA300 lineages diverged from a most recent common ancestor around 1970 with high confidence, and it also pinpoints the independent acquisition events of the of the ACME and COMER loci with greater precision than in previous studies. We provide evidence for a North American origin of the USA300 lineage and identify multiple introductions of USA300 into South and North America. Notably, we describe a third major USA300 clade (the pre-epidemic branching clade; PEB1) consisting of both MSSA and MRSA isolates circulating around the world that diverged from the USA300 lineage prior to the establishment of the South and North American epidemics. We present a detailed analysis of specific sequence characteristics of each of the major clades, and present diagnostic positions that can be used to classify new genomes.