bluuebunny/crossref_metadata_2025_split huggingface dataset:
uso da telessaúde e telemedicina à profissionais e para usuários como suporte assistencial e informacional
Authors: Silva Zaqueu Jhônathas Santos da , Farias Gabriel dos Santos , Silva Gerson Vanderley de Almeida , Oliveira Maurício de 
Published: March 2023

A sociedade da informação da era pós-industrial e globalizada, é sem dúvida permeada pela difusão em massa das mais variadas informações nas diversas áreas do conhecimento, disponibilizadas nos mais diferentes suportes, em destaque, aquelas que estão inseridas na rede mundial de computadores, por meio de buscadores que indexam as informações com robôs, ou bancos de dados, repositorios digitais e ou portais com informações específicas e tratadas. A partir dessa necessidade de sistematização, a saúde precisou se organizar e adentrar utilizando-se de formas mais modernas como meios virtuais e digitais. Objetivo: É realizar um levantamento bibliográfico sobre o uso da Telessaúde e Telemedicina como suporte assistencial e informacional aos profissionais e usuários, nos periódicos científicos dos segmentos da informação e comunicação no Brasil. Metodologia: O tipo de pesquisa escolhido foi à Revisão Integrativa, que proporciona envolver levantamento bibliográfico; análise de exemplos e assumir formas de pesquisa bibliográfica. Resultados e Discursões: Durante a pesquisa localizamos um total de 17 revistas da Área de Ciência da Informação, classificadas com conceito Qualis que variou de A1 até B5. Foi possível recuperar 65 artigos científicos divididos nos termos: Telessaúde; Telemedicina; e Usuário de Saúde. Com os resultados, buscou-se identificar qual a importância da telessaúde para os usuários de saúde do Brasil, e a interação entre profissionais e clientes, a partir de uma análise em artigos científicos voltados ao contexto informacional e de comunicação na saúde. Considerações finais: Podemos afirmar que o Brasil apresenta um viés relevante na área da Telessaúde, a partir do Sistema Único de Saúde - SUS, nesse contexto, o programa possibilita mapear e gerar dados e estatísticas voltados a usuários da informação em saúde a nível nacional.
Computational Strategies Targeting Inhibition of Helicobacter pylori and
Cryptococcus neoformans Ureases
Authors: Fabris Marciéli , Nascimento-Júnior Nailton M. , Bispo Marcelle L.F. , Camargo Priscila G. 
Published: March 2023

Abstract:
Helicobacter pylori and Cryptococcus ssp. are pathogenic ureolytic microorganisms that cause several
disorders in the host organism and, in severe cases, lead to death. Both infections have the urease enzyme
as a key virulence factor since they use its ability to produce ammonia to soften the inhospitable pH to which
they are subjected. In this review, we describe two ureases as possible molecular targets for drug discovery and
provide insights for developing potent inhibitors against ureases from these pathogenic microorganisms through
computer-aided drug discovery approaches, such as structure-based drug design (SBDD) and structure-activity
relationship (SAR). The SAR studies have indicated several essential subunits and groups to be present in urease
inhibitors that are critical for inhibitory activity against H. pylori or Cryptococcus spp. Since the threedimensional
structure of C. neoformans urease has yet to be determined experimentally, the plant urease of
Canavalia ensiformis was used in this study due to its structural similarity. Therefore, in the SBDD context,
FTMap and FTSite analyses were performed to reveal characteristics of the urease active sites in two protein
data bank files (4H9M, Canavalia ensiformis, and 6ZJA, H. pylori). Finally, a docking-based analysis was performed
to explore the best inhibitors described in the literature to understand the role of the ligand interactions
with the key residues in complex ligand-urease stabilization, which can be applied in the design of novel bioactive
compounds.
Complex Oligomers and their Bioactivity of Annonaceae Family
Authors: Chen Ling , Ren Youdi , Dai Wei-Feng , Yuan Cheng , Zhang Mi 
Published: March 2023

Background::
A series of novel oligomers with various types and complex skeletons are
isolated from Annonaceae plants, which displayed anti-inflammatory, antimalarial, antibacterial
and other biological activities. Thus, their structures and functions have received more and more
attention.

Aim and Objective::
The purpose of this review is to provide a systematic reference for chemical
structures and biological activities of oligomers and some clues for finding more analogues from
Annonaceae.

Methods::
Publications relevant to Annonaceae were retrieved from the Web of Science and
SciFinder and surveyed for a literature review.

Results::
This article summarized the chemical structures, the base source plants and the biofunctions
of oligomers from Annonaceae.

Conclusion::
The oligomers from Annonaceae have the characteristics of various connection
modes and rich functional groups, which provides more possibilities for the discovery of lead
compounds with new or higher biological activities.
Suppression of mTOR Expression by siRNA Leads to Cell Cycle Arrest
and Apoptosis Induction in MDA-MB-231 Breast Cancer Cells
Authors: Sahu Roja , Jha Shivesh , Pattanayak Shakti P. 
Published: March 2023

Background::
Mammary carcinogenesis, being ranked second in cancer-related mortality
and the inadequacy of existing chemotherapy advocates the development of a novel treatment approach
targeting its molecular signalling. Hyperactivation of mammalian target of rapamycin (mTOR)
has a critical role in developing invasive mammary cancer and it can be a potential target.

Objective::
This experiment was to explore the efficacy of mTOR-specific siRNA on therapeutic targeting
of the mTOR gene, assess its proficiency in suppressing in vitro breast cancer and determine
underlying molecular mechanisms.

Methods::
Specific siRNA targeting mTOR was transfected into MDA-MB-231 cells and mTOR
downregulation was validated through qRT-PCR and western blot analysis. Cell proliferation was analysed
by MTT assay and confocal microscopy. Apoptosis was studied through flow cytometry and
S6K, GSK-3β and caspase 3 expression were estimated. Further, the effect of mTOR blockade on cell
cycle progression was determined.

Results::
Following transfection of mTOR-siRNA into the MDA-MB-231 cells, cell viability and
apoptosis were examined which indicates that clinically relevant concentration of mTOR-siRNA inhibited
cell growth and proliferation and promote apoptosis, resulting from the suppression of mTOR.
This leads to the downregulation of mTOR downstream S6K and upregulation of GSK-3β. An increased
level of caspase 3 symbolises that the apoptotic activity is mediated through caspasedependent
pathway. Further, mTOR downregulation causes cell cycle arrest in G0/G1 phase as observed
in the flow cytometry study.

Conclusion::
With these results, we can conclude that mTOR-siRNA exerts direct ‘anti-breast cancer’
activity propagated by the S6K-GSK-3β- caspase 3 mediated apoptosis and by inducing cell cycle arrest.
Review on the Discovery of Water Absorbance Spectral Pattern in Aquaphotomics
based on Chemometrics Analytical Tools
Authors: Ma Xiaobo , Lin Boran , Zhao Bing , Wei Xiaoying , Dong Qin , Zhang Hui , Li Lian , Zang Hengchang 
Published: March 2023

Abstract:
Aquaphotomics, as a new discipline is a powerful tool for exploring the relationship be-tween the structure of water and the function of matter by analyzing the interaction between water and light of various frequencies. However, chemometric tools, especially the Water Absorbance Spectral Pattern (WASP) determinations, are essential in this kind of data mining. In this review, different state-of-the-art chemometrics methods were introduced to determine the WASP of aque-ous systems. We elucidate the methods used for identifying activated water bands in three aspects, namely: 1) improving spectral resolution; the complexity of water species in aqueous systems leads to a serious overlap of NIR spectral signals, therefore, we need to obtain reliable information hidden in spectra, 2) extracting spectral features; sometimes, certain spectral information cannot be re-vealed by simple data processing, it is necessary to extract deep data information, 3) overlapping peak separation; since the spectral signal is produced by multiple factors, overlapping peak separa-tion can be used to facilitate the extraction of spectral components. The combined use of various methods can characterize the changes of different water species in the system with disturbance and can determine the WASP. WASPs of research systems vary from each other, and it is visually dis-played in the form of the aquagram. As a new omics family member, aquaphotomics could be ap-plied as a holistic marker in multidisciplinary fields.
In silico Evaluation and Neuroprotective Effect of Jasmonic Acid on Sleep Deprivation Induced Alzheimer’s in Zebrafish
Authors: Thamaraikani Tamilanban , Anandan Vijay Babu , Karnam Manasa , Vasanthan Manimaran , Kichenamurthy Gayathiri 
Published: March 2023

Background:Disturbances in the sleep cycle have been often associated with the depletion of oxidant enzymes and deposition of beta-amyloid plaques leading to neurodegeneration in Alzheimer's disease (AD). Healthy sleep time and sleep cycles were proven to clear the betaamyloid out of the brain and also promote the synthesis and functions of anti-oxidant enzymes.Objective:Jasmonic acid was evaluated to enhance the cognition and acetylcholine enzyme in the sleep deprivation-induced Alzheimer's by using the zebrafish model.Methods:The molecular properties, bioactivity score, and pharmacokinetic parameters of jasmonic acid were predicted using Molinspiration, SwissADME, and PreADMET tools. Jasmonic acid obeys Lipinski's rule and has significant bioavailability and blood-brain barrier penetration. The prediction of binding energy and interactions of jasmonic acid with six selected receptors was performed using AutoDock 4.2 software. It has significant binding affinity and interactions with different receptors which predict a multi-target potential using in-silico studies. In vivo neurobehavioral analysis of jasmonic acid was performed with zebrafish by using T-maze, Y-maze, and inhibitory avoidance apparatus and the results reveal Jasmonic acid produces more memory retention in zebrafish. In vitro assays of jasmonic acid on acetylcholinesterase enzyme level, glucose level, catalase activity, and lipid peroxidation activity were performed. Jasmonic acid shows cholinesterase inhibition, it acts as a good anti-oxidant and increases glucose metabolism on zebra fish brain homogenate using various assays. Jasmonic acid decreases neurodegeneration, and amyloid deposits in zebrafish brains using histopathological studies.Results:In silico molecular docking studies, in vitro assays, in vivo neurobehavioral analysis and histopathological studies reveal that jasmonic acid showed significant activity against sleep deprivation- induced AD in the zebrafish model.Conclusion:Hence, jasmonic acid will be carried out for further preclinical and clinical studies in order to prove the same for the management of Alzheimer's disease.
The Role of Urinary miRNAs in the Diagnosis, Management and Follow-
Up of Prostatic Cancer
Authors: Ziogou Afroditi , Giannakodimos Alexios , Giannakodimos Ilias 
Published: March 2023

Abstract:
Diagnosis and management of prostatic cancer (PCa) cases mainly rely on levels of pros-tatic-specific antigen (PSA) levels. In the majority of cases, rising of PCa is usually responsible for elevated PSA. However, a wide variety of prostatic abnormalities, such as benign prostatic hyper-plasia and infection or inflammation of the prostatic glands, may also impact prostate levels. Due to the low specificity and sensitivity of the PSA test, elevated PSA levels can lead to unnecessary pros-tate biopsies or surgical interventions, constituting this diagnostic modality a controversial screening test. Therefore, the discovery of new non-invasive biomarkers, such as urinary miRNAs, could shed light on the optimal management and follow-up of patients with prostatic lesions. This review aims to evaluate the utility of urinary miRNAs as a new PCa prognostic biomarker, discovering its cur-rent limitations and proposing methods to overwhelm current challenges.
INTERNALISASI PENDIDIKAN KARAKTER DALAM PERSPEKTIF DAYAH
Authors: Helmi  
Published: March 2023

Dayah as the oldest education world in Aceh is also the world trying to educate his students (santri) not only able to master the science of religion (transfer of knowledge) also focuses the students are able to interrogate themselves figure character and character karimah. In general, education not only makes children smart, but also must be able to create noble values or character. Education maqasid character (purpose), first, develop the potential of the heart or conscience of learners as human beings and citizens who have the character of the nation. Second, develop the commendable habits and behaviors of learners and in line with the universal values and cultural traditions of a religious nation. Third, Instill the spirit of leadership and responsibility of learners as the successor of the nation. Fourth, Develop the ability of learners to become independent, creative, and national-minded human beings. Dayah Aceh in the internalization of character education does it by several methods, including: method of accuracy, method of practice and habituation, method of advising, method of targhib wa tahzib (motivation and punishment), method of persuasion, method of story in addition to the methods mentioned above there are other methods, among others, methods of proverbs (examples), tajribi (practice experience) and others. At least with the existence of a berkarkater education in dayah able to restore ilāhiyyah values in humans (fisān kāmil) especially santri with the guidance of the Qur'an and al-Hadīth, ijma' and qias so that it becomes a human being with noble character (insān kāmil) through the touch of the teacher's hand in dayah.
KEMAMPUAN GURU PAI PPG DALJAB DALAM MERANCANG SOAL HOTS PILIHAN GANDA
Authors: Realita  
Published: March 2023

Composing questions based on HOTS (Higher Order Thinking Skill) is one of the competencies that must be possessed by teachers in the 21st century, especially teachers who have been trained in the Professional Teacher Program (PPG Daljab). This paper aims to measure the competence of Islamic Education (PAI) teachers who were in in-service training program (PPG Daljab 2021) in designing HOTS-based multiple choice questions. This is a descriptive quantitative research. The data was collected by analyzing multiple choice questions made by PAI PPG teachers. The questions were analyzed using the percentage formula. The subject of this research was the teacher of PAI PPG Daljab 2021 at the Islamic University of Ar-Raniry session 2, totaling 12 teachers. The results of the study revealed that the ability of PAI PPG Daljab teachers 2021 in designing HOTS- based questions was in the good category with a score of 58%.
MENULIS KARANGAN NARASI SEBAGAI WADAH MENGEMBANGKAN BERPIKIR KREATIF
Authors: Silvia Sandi Wisuda Lubis  
Published: March 2023

Writing skills are indirect communication activities or often called nonverbal communication tools, writing has the same meaning as composing, such as writing narrative essays. Wiriting activities require a process of thinking and imagining to be able to convey what is meant to the reader. The activity of writing narrative essays has become a topic of discussion in Indonesian subjects to be studied and is useful for developing writing skills. Narrative essays whose sources of development are through things that are closely related to every day life encountered in yhe surrounding environment can provide many ideas for developing them into writing. Creative ability is generally understood as creativity. Often, the individual who is considered creative is a genuinely good synthetic thinker who builds connections between things that other people don’t notice spontaneously. A creative attitude is at least as important as creative thinking skills. Creativity is relative. This study uses a qualitative research approach where qualitative research as a scientific method is often used and carried out by a group of researchers in the social sciences, including education sciences. The data were analyzed using the percentage formula. The results showed that the percentage of students writing narrative essays was 94.59 % very well and students had completed classically.
role of miRNA -150 between different BCR-ABL p210 transcript levels and between different levels of imatinib optimal response in CML patients
Authors: Radhi Kawthar Ali , Matti Bassam Francis , Hamzah Israa Hussein , Alkasir Rashad 
Published: March 2023

The dysregulation of miRNA expression patterns is one of the many effects developments of cancer, miRNA has been found to express abnormally in hematological neoplasia such as chronic myeloid leukemia and solid malignancies. Resistance and the degree of response following tyrosine kinase inhibitor treatment are correlated with miRNA expression. Hence, in this study we tried to study the relationship of miRNA-150 between different breakpoint cluster region–Abelson (BCR- ABL) P210 transcript levels and the role miRNA- 150 between different levels of imatinib optimal response in chronic myeloid leukemia (CML). Our study included sixty chronic myeloid leukemia (CML) patients they were divided into two groups based on response to imatinib therapy, thirty samples of the optimal molecular response of chronic myeloid leukemia (CML) patients, and thirty samples of failure molecular response chronic myeloid leukemia (CML) patients. Thirty samples of apparently healthy volunteers were included and evaluated as control. According to the P210 BCR-ABL%, the results showed a significant difference (P= < 0.0001) between the responder and the failure response CML patients. Assessed the result of miRNA-150 showed a significant difference between both CML patients (P = < 0.0001), assessed miRNA-150 level among different response groups, and failure response of CML patients (P = 0.0002). A cutoff value of response vs. failure response (1.784) with high sensitivity can be a diagnostic value to differentiate between response and failure response. Changing gene expression with different amounts of miRNAs had an impact on drug-gene interactions, with consequences for cell growth and death. Gene expression of different levels miRNA-150 among of CML patients of imatinib therapy showed high expression in response patients than failure response patients. The gene expression level of miRNA-150 differs through different responses in CML patients.
Perancangan Dan Pembuatan Website Inventori Barang Dengan Metode Waterfall (Studi Kasus Sakti Brem)
Authors: Fatimah Siti 
Published: March 2023

<p>UMKM Sakti Brem merupakan salah satu produsen brem yang sukses di Kabupaten Madiun. Namun, dibalik kesuksesannya Sakti brem masih melakukan pencatatan inventori secara manual di dalam sebuah buku. Hal ini kerap meyebabkan ketidakakuratan jumlah dari stok barang, karena owner terkadang tidak langsung mencatat penjualan ketika owner masih sibuk dan akhirnya lupa tidak mencatatnya. Untuk mengatasi hal tersebut, maka dibuat sebuah website inventori barang menggunakan metode waterfall. Metode waterfall dipilih dalam perancangan dan pembuatan website inventori barang dikarenakan dalam pengembangan sistemnya dikerjakan secara berurutan sehinggga memudahkan pembuatan suatu sistem informasi. Hasil dari penelitian berdasarkan pengujian sistem menggunakan metode <em>blackbox testing </em>semua fitur berjalan dengan baik sesuai harapan. Sedangkan pada pengujian <em>usability testing</em> hasilnya pengguna merasa semua fitur website inventori barang UMKM Sakti Brem berfungsi seperti yang diharapkan, dan pengguna merasa puas terhadap website inventori barang UMKM Sakti Brem. Hal ini sesuai dengan penilaian terhadap keempat faktor yang diuji dimana masing-masing hasilnya mendapatkan nilai rata-rata sangat baik.</p><p><strong>Kata kunci: </strong>Brem, Website, Inventori Barang, Metode Waterfall</p>
Diseño e implementación de metodología para la creación de laboratorios remotos de docencia: caso de estudio Sistema de Acondicionamiento de Aire
Authors: Garcia Buitrago Maria Vilma , Martínez Pérez Adrián , Isaza Hurtado Jhon , Vélez García Sebastián 
Published: March 2023

Las condiciones de pandemia han llevado a la educación a buscar formas alternativas de llegar a los estudiantes con un proceso formativo similar a las condiciones de la presencialidad. Existen muchas herramientas virtuales para el aprendizaje a través de aplicativos webs, pero estos medios no reemplazan la interacción con los equipos reales. Las herramientas tecnológicas deben ser exploradas a profundidad de tal forma que permitan generar una experiencia cercana con los equipos de laboratorio. Por esta razón, en este artículo se presenta una propuesta metodológica para repotenciar laboratorios disponibles en instituciones universitarias, facilitando el acceso remoto a los dispositivos. Esta metodología integra la experiencia pedagógica y tecnológica de docentes y estudiantes y es implementada en un equipo de aire acondicionado del laboratorio de fluidos del Instituto Tecnológico Metropolitano (ITM) de Medellín.
Supervisi Klinis Sebagai Upaya Peningkatan Kemampuan Guru Memahami Bahan Ajar di Sekolah
Authors: Kau Swirna DJ. , Atute Imran 
Published: March 2023

Bahan ajar merupakan sesuatu yang bermakna bagi peserta didik maupun guru. Penelitian ini bertujuan untuk meningkatkan kemampuan pemahaman guru tentang bahan ajar dengan menggunakan supervisi klinis pada guru di SMP Negeri 2 Satap Tabongo. Penelitian ini menggunakan metode kuantitatif dengan teknik pengumpulan data yakni pengamatan dan dokumentasi, dengan teknik analisis data yaitu menjabarkan secara rinci perencanaan, pelaksanaan dan pengamatan. Hasil penelitian ini menunjukkan bahwa supervisi klinis dapat meningkatkan kemampuan guru SMP Negeri 2 Satap Tabongo dalam memahami bahan ajar. Hal ini tampak dari 5 indikator penguasaan bahan ajar yaitu kemampuan (a) merencanakan bahan ajar, (b) mengorganisasikan bahan ajar, (c) memilih bahan ajar yang sesuai dengan kebutuhan dan karakteristik peserta didik, (d) mengolaborasikan bahan ajar dengan sumber belajar lain, dan (e) menggunakan bahan ajar dalam proses pembelajaran.