bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pan-cancer analysis of the prognostic and immunological roles of matrix metalloprotease-1 (MMP1) in human tumors
Authors: Mao Shuai , Xia Anliang , Tao Xuewen , Ye Dingde , Qu Jiamu , Sun Meiling , Wei Haowei , Li Guoqiang 
Published: January 2023

ObjectiveCancer remains the leading killer of human health worldwide. It has been shown that matrix metalloproteinase-1(MMP1) is related to poor prognosis in cancers such as BRCA, CESC and COAD. However, systematic pan-cancer analysis about the prognostic and immunological roles of MMP1 has not been explored. Here, the purpose of this study was to investigate the prognostic and immunological roles of MMP1 in pan-cancer and confirm cancer-promoting effect in pancreatic cancer.MethodsIn our study, bioinformatics were first used to analyze data from multiple databases. Then, several bioinformatics tools were utilized to investigate the role of MMP1 in 33 tumor types. Finally, molecular biology experiments were carried out to prove the cancer-promoting effect of MMP1 in pancreatic cancer.ResultsMMP1 expression was higher in tumor tissues than in control tissues in most tumor types. High expression of MMP1 was associated with poor overall survival (OS) and disease-free survival (DFS) in some tumor types. Further analysis of MMP1 gene mutation data showed that MMP1 mutations significantly influenced the prognosis of STAD. In addition, MMP1 expression was closely related to cancer-associated fibroblast (CAFs) infiltration in a variety of cancers and played an important role on immune infiltration score, tumor mutational burden (TMB) and microsatellite instability (MSI). Gene Ontology enrichment analysis indicated that these 20 genes were mainly related to extracellular structure organization/extracellular matrix organization/extracellular matrix disassembly/collagen metabolic process in the enriched biological processes. Finally, molecular biology experiments confirmed the cancer-promoting effect of MMP1 in pancreatic cancer.ConclusionsOur pan-cancer analysis comprehensively proved that MMP1 expression is related with clinical prognosis and tumor immune infiltration, and MMP1 can become a prognostic and immunological biomarker.
Analysis of the clinicopathological characteristics and prognosis of triple-positive breast cancer and HER2-positive breast cancer—A retrospective study
Authors: Ma Dongxu , Yang Qing , Yin Ke , Shi Peng , Chen Xiao , Dong Tianyi , Shang Xingchen , Tian Xingsong 
Published: January 2023

BackgroundAdjuvant chemotherapy and targeted therapy have become standard postoperative therapeutic modalities for human epidermal growth factor receptor 2 (HER2)-positive breast cancer(HER2-positive,HR-negative), including triple-positive breast cancer(HER2-positive,HR-positive). However, these two types of breast cancer differ in terms of pathogenesis. This article analyzes these two types of breast cancer by comparing their prognoses.MethodsThe clinicopathological characteristics of 135 patients, including 60 patients with triple-positive breast cancer and 75 patients with HER2-positive breast cancer, were analyzed to compare the disease-free survival (DFS) and overall survival (OS) of the two groups over a 5-year period. A multifactorial Cox risk model was constructed by grouping age, menstrual status, maximum tumor diameter, number of lymph node metastases, pathological staging, and Ki-67 staining results. All statistical data were analyzed in detail using SPSS25.0 statistical software.ResultsThe 5-year OS rates of patients with breast cancer in the triple-positive and HER2-positive groups were 96.7% and 82.7%, respectively, and the 5-year DFS rates were 90% and 73.3%, respectively. The Cox results revealed that molecular staging was an independent factor affecting recurrent metastasis and survival of breast cancer patients (hazard ratio [HR] =2.199, 95% confidence interval [CI], 1.296-8.266; HR = 9.994, 95% CI, 2.019-49.465).ConclusionThe 5-year DFS and OS rates were significantly better in the triple-positive group than in the HER2-positive group. Subgroups received different prognosis for different chemotherapy regimens. Breast cancer patients should be treated according to the risk of recurrence with symptomatic treatment and precise regulation.
Radiation pneumonitis following Yttrium-90 radioembolization: A Korean multicenter study
Authors: Kim Hyo-Cheol , Kim Gyoung Min 
Published: January 2023

ObjectiveTo report the incidence of radiation pneumonitis after radioembolization.MethodsIn this retrospective study, from May 2009 to July 2021, 782 consecutive patients underwent radioembolization in two institutes. Medical internal radiation dose dosimetry and partition dosimetry were used for glass and resin Yttrium-90-labeled microspheres (90Y-microspheres), respectively. Medical records and radiological findings were retrospectively evaluated with emphasis on the symptomatic radiation pneumonitis.ResultsOf the 732 patients with lung shunt study and follow-up, 13 (1.8%) had symptomatic radiation pneumonitis and six patients died due to radiation pneumonitis. Of the 721 patients whose lung doses were calculated, 10 patients who were treated with glass (n = 5) and resin (n = 5) 90Y-microspheres had radiation pneumonitis. No significant statistical difference between glass and resin 90Y-microspheres (p = 0.304) was noted in terms of radiation pneumonitis incidence. Among the patients with radiation pneumonitis, all five patients treated with glass 90Y-microspheres had estimated lung doses &gt; 29 Gy, whereas five patients treated with resin 90Y-microspheres had relatively wide range of lung dose reaching much lower value (13.21Gy).ConclusionThe present study suggests that radiation pneumonitis after radioembolization may occur even though the manufacturer’s instructions are followed.
Retrospective analysis of longitudinal melanonychia: A Chinese experience
Authors: Lyu Anqi , Hou Yinglong , Wang Qiying 
Published: January 2023

ObjectiveWe aimed to analyze the clinical and histopathologic characteristics of longitudinal melanonychia (LM), explore the differences between adults and children, and propose some recommendations.MethodsData on pigmentation, lentigo, subungual melanoma (SUM), and nail matrix nevus (NMN) were acquired for comparison.ResultsLesions on thumbs in the children’s group were significantly fewer (p = 0.006) than in adults. Lesions on little fingers in children were more than in adults; the difference was statistically significant (p = 0.025). The widths of bands in adults were wider than in children (p &lt; 0.001), and the duration and width were positively correlated (r = 0.474). There was more pigmentation in adults than in children; the difference was statistically significant (p = 0.005). NMN was reported in 56.1% children and 34.3% adults; the difference was statistically significant (p = 0.005). Adults had six SUM cases, whereas none in children; the difference was statistically significant (p = 0.006). The recurrence rate in adults was significantly higher than in children (p = 0.019).ConclusionThe widths of bands increase with the course, indicating that LM may be progressive. The four pathological types have different distributions with age, and each type requires different treatment. The lower recurrence rate in children suggests that LM needs diagnosis and appropriate treatment as soon as possible.
Impact of muscle mass on the prognosis of liver transplantation for infants with biliary atresia
Authors: Lledín María D. , Parrón-Pajares Manuel , Morais Ana , Hernández-Oliveros Francisco , Botella-Carretero Jose I. , Hierro Loreto 
Published: January 2023

BackgroundSarcopenia in adult cirrhotic patients is associated with increased morbidity and mortality whereas in children it is still being studied. Anthropometric variables in cirrhotic children are not reliable for assessing muscle mass as they may be altered by ascites, edema, and organomegaly. Measuring the area of the psoas showed good correlation with muscle mass in adults. We aimed to study in cirrhotic infants undergoing liver transplantation the association of the psoas area with liver transplant prognosis as well as with several analytical and anthropometric parameters used to evaluate nutritional status.MethodsRetrospective cohort of 29 infants with cirrhosis due to biliary atresia who underwent abdominal CT scan as a pre-transplant study. We measured the psoas muscle index (PMI) at L4-L5 since it best correlates with muscle mass in pediatric patients. As there are no validated cut-off points to define sarcopenia in children under one year of age, PMI was recorded as a continuous variable and correlated with different prognostic, clinical, and analytical variables. The SPSS 17.0 package was used for statistical analysis and a P &lt; 0.05 was considered significant.Results29 infants (10 boys, 19 girls) were studied. 62% were Caucasian and the rest were South American. The mean age at CT scan was 8.5 months (range 3–15 months). There was a negative correlation between PMI and days of admission prior to liver transplant, previous infections, and bone fractures. Among the analytical parameters, cholinesterase, albumin, and prealbumin correlated positively with PMI (P &lt; 0.05). No relationship was observed with anthropometric parameters: weight, height, BMI, brachial perimeter, or bioimpedance. During surgery, patients with lower PMI had a greater need for plasma transfusion, and in the immediate postoperative period, there was a longer stay in intensive care, more days of mechanical ventilation, and more days of hospital admission (P &lt; 0.05). On the contrary, no relationship was found with other complications: bleeding, re-interventions, biliary leaks, rejection, thrombosis, re-transplantation, or infections.ConclusionsThe decrease in muscle mass is associated with increased morbidity in infants with biliary atresia undergoing liver transplantation. Muscle mass in these patients cannot be adequately assessed with anthropometric measurements commonly used in the clinic.
Fetal–neonatal exposure to antibiotics and NEC development: A systematic review and meta-analysis
Authors: Klerk Daphne H. , van Avezaath Lisanne K. , Loeffen Erik A. H. , Hulscher Jan B. F. , Kooi Elisabeth M. W. 
Published: January 2023

BackgroundFetal and neonatal exposure to antibiotics may contribute to the development of necrotizing enterocolitis (NEC) in preterm infants. This systematic review and meta-analysis investigate whether exposure to third trimester maternal antibiotics (MAB) and/or prolongation of empirical antibiotics (PEAB) are associated with NEC development in preterms.MethodWe included observational and randomized controlled studies, including those on preterm or very low birth weight (VLBW) infants, from MEDLINE and EMBASE, published between 1990 and June 2021. Exposure was defined as third trimester MAB and/or PEAB. The two reviewers independently performed study selection, data extraction, and quality assessment.ResultsThree cohort studies compared third trimester MAB with no antibiotics. MAB was associated with lower NEC incidence, unadjusted pooled odds ratio (OR) is 0.57 (95% CI: 0.35–0.93). Twelve cohort studies showed that PEAB was associated with an increased risk of NEC. Ten observational cohort studies show an unadjusted OR of 2.72 (1.65–4.47), and two case–control studies show an unadjusted mean difference of 2.31 (0.94–3.68). Moderate to substantial heterogeneity was observed but decreased in studies with low risk of bias and large sample size.ConclusionEvidence suggests an association between MAB and decreased risk of NEC and an association between PEAB and increased risk of NEC. Further studies should confirm these associations and explore causality.Systematic Review Registrationidentifier [CRD42022304937].
Neuroregeneration of injured peripheral nerve by fraction B of catfish epidermal secretions through the reversal of the apoptotic pathway and DNA damage
Authors: Al-Arbeed Taiba A. , Renno Waleed M. , Al-Hassan Jassim M. 
Published: January 2023

Introduction: Crush injuries occur from acute traumatic nerve compression resulting in different degrees of neural damage leading to permanent functional deficits. Recently, we have shown that administration of Fraction B (FB) derived from catfish epidermal secretions accelerates healing of damaged nerve in a sciatic nerve crush injury, as it ameliorates the neurobehavioral deficits and enhances axonal regeneration, as well as protects spinal neurons and increases astrocytic activity and decreasing GAP-43 expression. The present study aimed to investigate the role of FB treatment on the apoptotic pathway in the neuroregeneration of the sciatic nerve crush injury.Methods: Male Wistar rats were randomly assigned into five groups: (I) SHAM, (II) CRUSH, (III) CRUSH + (1.5 mg/kg) FB, (IV) CRUSH + (3 mg/kg) FB, and (V) CRUSH + (4.5 mg/kg) FB. Rats underwent sciatic nerve crush surgery, followed by treatment with FB administered intraperitoneally (IP) daily for two weeks and then sacrificed at the end of the fourth week.Results: FB improved the recovery of neurobehavioral functions with a concomitant increase in axonal regeneration and neuroprotective effects on spinal cord neurons following crush injury. Further, FB enhanced Schwann cells (SCs) proliferation with a significant increase in myelin basic protein expression. FB-treated animals demonstrated higher numbers of neurons in the spinal cord, possibly through ameliorating oxidative DNA damage and alleviating the mitochondrial-dependent apoptotic pathway by inhibiting the release of cytochrome c and the activation of caspase-3 in the spinal cord neurons.Conclusion: FB alleviates the neurodegenerative changes in the lumbar spinal cord neurons and recovers the decrease in the neuronal count through its anti-apoptotic and DNA antioxidative properties.
Molecular characterization based on tumor microenvironment-related signatures for guiding immunotherapy and therapeutic resistance in lung adenocarcinoma
Authors: Jie Yamin , Wu Jianing , An Dongxue , Li Man , He Hongjiang , Wang Duo , Gu Anxin , E Mingyan 
Published: January 2023

Background: Although the role of tumor microenvironment in lung adenocarcinoma (LUAD) has been explored in a number of studies, the value of TME-related signatures in immunotherapy has not been comprehensively characterized.Materials and Methods: Consensus clustering was conducted to characterize TME-based molecular subtypes using transcription data of LUAD samples. The biological pathways and immune microenvironment were assessed by CIBERSORT, ESTIMATE, and gene set enrichment analysis. A TME-related risk model was established through the algorithms of least absolute shrinkage and selection operator (Lasso) and stepwise Akaike information criterion (stepAIC).Results: Four TME-based molecular subtypes including C1, C2, C3, and C4 were identified, and they showed distinct overall survival, genomic characteristics, DNA methylation pattern, immune microenvironment, and biological pathways. C1 had the worst prognosis and high tumor proliferation rate. C3 and C4 had higher enrichment of anti-tumor signatures compared to C1 and C2. C4 had evidently low enrichment of epithelial–mesenchymal transition (EMT) signature and tumor proliferation rate. C3 was predicted to be more sensitive to immunotherapy compared with other subtypes. C1 is more sensitive to chemotherapy drugs, including Docetaxel, Vinorelbine and Cisplatin, while C3 is more sensitive to Paclitaxel. A five-gene risk model was constructed, which showed a favorable performance in three independent datasets. Low-risk group showed a longer overall survival, more infiltrated immune cells, and higher response to immunotherapy than high-risk group.Conclusion: This study comprehensively characterized the molecular features of LUAD patients based on TME-related signatures, demonstrating the potential of TME-based signatures in exploring the mechanisms of LUAD development. The TME-related risk model was of clinical value to predict LUAD prognosis and guide immunotherapy.
Biomechanics of the lead straight punch and related indexes between sanda fighters and boxers from the perspective of cross-border talent transfer
Authors: Liu Yang , Li Lei , Yan Xianliang , He Xinseng , Zhao Bin 
Published: January 2023

Objective: To bridge the technical gaps in reserve athletes in China’s national boxing program and to rapidly improve the overall level of boxing, the Wushu Sports Administration Center of the General Administration of Sports of China has sent outstanding Sanda players to boxing events through cross-border talent transfer. This was done to widely improve the strengths and resources in various fields to prepare for the Tokyo Olympic Games. In view of this, we analyzed and compared differences in biomechanical parameters of the lead straight punch and index of force developments of the lower extremities between Sanda and boxing. The results provide information and insights to bridge the technical gaps in cross-border talent transfer from Sanda to boxing.Methods: We employed a Vicon infrared 3D motion capture system, two Kistler platforms, a Kistler target, and a synchronous instrument. Eleven boxers and sixteen Sanda athletes were recruited, and their lead straight punch techniques were compared and analyzed. Three indexes of punch velocity, six indexes of strength measurement, and four indexes of lower extremity strength were analyzed.Results: Significant differences in the peak punch velocity and contact velocity were found between the two groups. Furthermore, significant differences were noted in the peak impulse, peak strength, relative strength, and the rate of force development (RFD). Among the kinetics indexes of lower limbs, the front leg strength index was higher in the boxing group than in the Sanda group, namely the RFD index and RFD/body mass.Conclusion: Based on the disparity in the effects of the lead straight punch and biomechanical parameters of both lower extremities, we can conclude that, compared to the boxers, most Sanda athletes lack standard punching technique. Therefore, it is advised that coaches and practitioners carefully consider selecting Sanda athletes with higher technical standards of punching.
Communicating telecom fraud risk in anti-telefraud messages: The effects of metaphorical frames on attitudes
Authors: Liu Mengna , Chen Jinshi 
Published: January 2023

IntroductionWith the frequent occurrences of telecom fraud crimes in China, it is very necessary and urgent to carry out effective anti-telefraud risk communication. In the present study, we investigated the role of metaphorical framing in shaping people’s attitudes toward telecom fraud in anti-telefraud messages through two experiments.MethodsParticipants (N = 547, Experiment 1;N = 604, Experiment 2) were randomly assigned to war-framing, disease-framing, or issue-framing conditions. They were asked to read anti-telefraud messages where metaphorical frames were realized through multiple metaphorical expressions in Experiment 1 and relatively shorter messages where metaphorical frames were only instantiated through one metaphorical word in Experiment 2.ResultsThe results showed that participants without prior experience with telecom fraud perceived severity as significantly higher in the war-framing condition than in the issue-framing condition. Besides, the framing effects were only detected in Experiment 2 where the short anti-telefraud message with limited metaphorical information was provided.DiscussionThe study reveals that even one metaphorical word is sufficient to build a framework for thinking about complex concepts, like telecom fraud, and prior experience with a certain risk can serve as a moderator of metaphorical framing on people’s risk perceptions. It is also found that the effectiveness of metaphors may be more salient in the genres of a short length such as anti-telefraud banners. The study can shed light on public legal educators whose job is to use effective ways to communicate telecom fraud risk to citizens.
The relationship between maternal-fetus attachment and perceived parental bonds in pregnant women: Considering a possible mediating role of psychological distress
Authors: Gioia Maria C. , Cerasa Antonio , Muggeo Vito M. R. , Tonin Paolo , Cajiao Juanita , Aloi Alessia , Martino Iolanda , Tenuta Flaviana , Costabile Angela , Craig Francesco 
Published: January 2023

Maternal-Fetal Attachment (MFA) delineates the emotional, cognitive, and behavioral aspects that mothers develop toward the unborn baby during pregnancy. The literature indicates that optimal attachment in pregnancy represents a protective factor for the mother-child attachment bond after birth and child development outcomes. To date, there are few studies that have investigated associated factors of MFA. This study sets out to explore the association between perceived parental bonds and maternal-fetal bonding in pregnant women, accounting for factors such as psychological distress, socio-demographic and obstetric characteristics.MethodsIn this cross-sectional study, 1,177 pregnant women answered the Parental Bonding Instrument, the Maternal-Fetal Attachment Scale, State-Trait Anxiety Inventory (STAI-Y), and Beck-Depression Inventory (BDI-II).ResultsWe found out that perceived maternal and paternal care had significant direct effects on maternal-infant bonding during the pregnancy period when controlling for some confounders, including gestational age and mother age among others. Such maternal and paternal perceived care effects were not mediated by levels of psychological distress, which in turn resulted to be a “borderline” significant predictor of prenatal attachment. Interestingly, the gestational age and the mother age emerged to have a significant and synergic nonlinear effect, suggesting the influence on the MFAS of the gestational age depends on the values of the mother age, and likewise, the effect of mother age on MFAS depends on the gestational week.ConclusionThis study expands our knowledge of the intergenerational transmission of attachment pointing out the effects of a woman’s perceived bond in relation to her parental figures during the development of the prenatal attachment process. Findings also suggests that parenting support interventions may have benefits that are realized across generations.