bluuebunny/crossref_metadata_2025_split huggingface dataset:
When CEO compensation plan based on risk changes firm strategic variation and strategic deviation? The moderating role of shareholder return
Authors: Severgnini Elizandra , Vieira Valter Afonso , Abib Gustavo , Leonel Ronei 
Published: September 2023

Purpose
The authors extend the recent research using the risk component of human resource’s (HR’s) compensation plans to examine the effects of risk components on two strategic outcomes: within-firm temporal change, or strategic variation, and firm strategic divergence from the industry, or strategic deviation. In addition, the authors examine the role of previous financial performance as a boundary moderator condition of the effects of risk components in the compensation plan and firm strategic outcomes.

Design/methodology/approach
To examine the effects of low- and high-risk components of executive compensation on strategic variation and deviation over time, the authors collected data from 2,510 companies listed in the Standard and Poor’s 500 index in a panel data format of a 12-year period. The authors gathered financial and other firm-level data from COMPUSTAT, and executive compensation and executive-level data from ExecuComp.

Findings
The findings support the main effects of risk components on strategic change, while both high- and low-risk components act on strategic deviation contingent on the moderating role of total shareholder return (TSR). In the theoretical framework, the authors test the moderating role of total shareholder return (TSR) as a boundary condition of the effects of risk components in the compensation plan. In doing so, the authors provide a fine-grained understanding of the influence of compensation plan risk components on outcomes proximal to executives, such as the maintenance of the status quo and the search for financial gains.

Research limitations/implications
New studies can explore a three-way moderating effect on performance indicators, such as TSR, Tobin’s Q and return on asset. The authors addressed this limitation and did a comparative analysis, but the authors did not include additional moderating mechanisms in these interactive effects.

Practical implications
By disaggregating the executive’s compensation based on the risk components, boards of directors can mitigate any possible unwanted biases in the relationship between principal and agent.

Originality/value
By considering the influence of both low- and high-risk components of compensation plans on strategic outcomes –instead of firm performance – this study expands strategy literature supporting the influence of compensation schema on a firm’s outcomes. This path is new because it offers a moderating perspective to understand the strategic deviations and changes that chief executive officers imprint in their firms.
Interfacial reactions in the Sn-9.0 wt.% Zn/Cu-Ti alloy (C1990 HP) couple
Authors: Laksono Andromeda Dwi , Chen Chih-Ming , Yen Yee-Wen 
Published: September 2023

Purpose
The purpose of this study was to examine the influence of adding a small amount of Ti to a Cu-based alloy, specifically the commercial Hyper Titanium Copper alloy (C1990 HP), which contains Cu-3.28 wt.% Ti, on its interfacial reaction with Sn-9.0 wt.% Zn (SnZn) solder, using the liquid/solid reaction couple technique.

Design/methodology/approach
The SnZn/C1990 HP couples were subjected to a reaction temperature of 240–270°C for a duration of 0.5–5 h. The resulting reaction couple was characterized using a scanning electron microscope, energy dispersive spectrometer, electron probe microanalyzer and X-ray diffractometer.

Findings
It was observed that the scallop-shaped CuZn5 and planar Cu5Zn8 phases were formed in almost all SnZn/C1990 HP couples. With increased reaction duration and temperature, the Cu-rich intermetallic compound (IMC)-Cu5Zn8 phase became a dominant IMC formed at the interface. The total thickness of the IMCs was increased with the increase in the reaction duration and temperature. The IMC growth obeyed the parabolic law, and the IMC growth mechanism was diffusion controlled. The activation energy of the SnZn/C1990 HP couple was 64.71 kJ/mol.

Originality/value
This article presents an analysis of the IMC thickness in each sample using ImageJ software, followed by kinetic analysis using Origin software at various reaction temperatures of SnZn/C1990 HP in liquid/solid couples. The study also includes detailed reports on the morphology, interface composition and X-ray diffraction analysis, as well as the activation energy. The findings can serve as a valuable reference for electronic packaging companies that utilize C1990 HP substrates.
Trans misogyny in the colonial archive: Re‐membering trans feminine life and death in New Spain, 1604–1821
Authors: Jesperson Jamey 
Published: September 2023

AbstractTraces of trans feminine pasts are scattered all across the colonial archive. In New Spain, glimpses of Indigenous trans women's lives can be found in the records of conquistadors as early as the sixteenth century. While such early colonial representations of trans femininity span myriad religious, imperial and literary contexts, they are all underpinned by one harrowing reality: the widespread, colonial pursuit of trans feminine death. To ‘re‐member’ – á la Saylesh Wesley – trans feminine pasts in the colonial archive, this article traces structures of, and resistance to, colonial trans misogyny in the sodomy criminal trials of Mexico (1604–1771) and the Catholic missions of California (1769–1821). Pushing against an extant ‘cistoriography’ that has simply archived these stories within the history of sexuality, I ask: What may be gleaned by centring trans femininity and womanhood as core to not only the lives of historical subjects, but the reason many of their lives were so violently taken? By re‐membering trans misogyny in this way, we may finally name and centre the long‐erased trans feminine historical subject, illuminate the complex, changing structures of her past worlds and trace the oft‐forgotten lineages of not just trans feminine death, but trans feminine survivance in its face.
Potential water‐related risks to the electric power industry associated with changing surface water conditions
Authors: Hersh Eric , Jackson Morgan , Menninger John , Shippee Norman , Thomas Jeff , Rao Nalini 
Published: September 2023

AbstractThis study identifies and summarizes potential risks to operations, regulatory compliance, supply chains, and infrastructure of the electric power industry from changing surface water conditions resulting from global climate change. The results help inform companies/utilities seeking to incorporate climate change risk in their planning and decision‐making processes by ranking risk severity and likelihood of occurrence on both a regional basis and by risk receptor. The assessment includes identification of potential risks to: (1) thermal generating, (2) hydroelectric, (3) land‐based renewable generating, and (4) transmission and distribution assets. These risks may result from such projected changes as reduced water availability (e.g., for hydroelectric or once‐through cooling), increased water temperatures (e.g., decrease in cooling efficiency, inability to meet discharge permit conditions), increased flood severity (e.g., increased streambank erosion and/or damage to river‐adjacent infrastructure), and decreased water quality (e.g., from increased transport of sediment and dissolved solids). The potential risks identified from this qualitative risk‐assessment are documented in a graphical format depicting both severity and likelihood. This approach allows for comparison of risks across a portfolio and for future prioritization of adaptation strategies. A total of 32 risks were identified in the study, including nine risks to infrastructure, six risks to operations, four risks to supply chain, and 13 environmental/regulatory risks.
Exercise ameliorating myocardial injury in type 2 diabetic rats by inhibiting excessive mitochondrial fission involving increased irisin expression and AMP‐activated protein kinase phosphorylation
Authors: Wang Bin , Zhao Chen , Wang Yuanxin , Tian Xin , Lin Junjie , Zhu Baishu , Zhou Yalan , Zhang Xin , Li Nan , Sun Yu , Xu Haocheng , Zhao Renqing 
Published: September 2023

AbstractPurposeThough exercise generates beneficial effects on diabetes‐associated cardiac damage, the underlying mechanism is largely unclear. Therefore, we prescribed a program of 8‐week treadmill training for type 2 diabetes mellitus (T2DM) rats and determined the role of irisin signaling, via interacting with AMP‐activated protein kinase (AMPK), in mediating the effects of exercise on myocardial injuries and mitochondrial fission.MethodsForty 8‐week‐old male Wistar rats were randomly divided into groups of control (Con), diabetes mellitus (DM), diabetes plus exercise (Ex), and diabetes plus exercise and Cyclo RGDyk (ExRg). Ex and ExRg rats received 8 weeks of treadmill running, and the rats in the ExRg group additionally were treated with a twice weekly injection of Cyclo RGDyk, an irisin receptor‐αV/β5 antagonist. At the end of the experiment, murine blood samples and heart tissues were collected and analyzed with methods of ELISA, Western blot, real‐time quantitative polymerase chain reaction, as well as immunofluorescence staining.ResultsExercise effectively mitigated T2DM‐related hyperglycemia, hyperinsulinemia, lipid dysmetabolism, and inflammation, which could be diminished by Cyclo RGDyk treatment. Additionally, exercise alleviated T2DM‐induced myocardial injury and excessive mitochondrial fission, whereas the beneficial effects were blocked by the administration of Cyclo RGDyk. T2DM significantly decreased serum irisin concentrations and fibronectin type III domain‐containing protein 5 (FNDC5)/irisin gene and protein expression levels in the rat heart, whereas exercise could rescue T2DM‐reduced FNDC5/irisin expression. Blocking irisin receptor signaling diminished the exercise‐alleviated mitochondrial fission protein expression and elevated AMPK phosphorylation.ConclusionExercise is effective in mitigating diabetes‐related insulin resistance, metabolic dysfunction, and inflammation. Irisin signaling engages in exercise‐associated beneficial effects on myocardial injury and excessive mitochondrial fission in diabetes rats involving elevated AMPK phosphorylation.
Expert consensus on the diagnosis and treatment of RET gene fusion non‐small cell lung cancer in China
Authors: Pu Xingxiang , Xu Chunwei , Wang Qian , Wang Wenxian , Wu Fang , Cai Xiuyu , Song Zhengbo , Yu Jinpu , Zhong Wenzhao , Wang Zhijie , Zhang Yongchang , Liu Jingjing , Zhang Shirong , Liu Anwen , Li Wen , Zhan Ping , Liu Hongbing , Lv Tangfeng , Miao Liyun , Min Lingfeng , Lin Gen , Huang Long , Yuan Jingping , Jiang Zhansheng , Rao Chuangzhou , Lv Dongqing , Yu Zongyang , Li Xiaoyan , Tang Chuanhao , Zhou Chengzhi , Zhang Junping , Guo Hui , Chu Qian , Meng Rui , Liu Xuewen , Wu Jingxun , Zhou Jin , Zhu Zhengfei , Pan Weiwei , Pang Fei , Huang Jintao , Wang Kai , Wu Fan , Shen Tingting , Zou Shirui , Xu Bingwei , Wang Liping , Zhu Youcai , Lin Xinqing , Cai Jing , Xu Ling , Li Jisheng , Jiao Xiaodong , Li Kainan , Feng Huijing , Wang Lin , Du Yingying , Yao Wang , Shi Xuefei , Niu Xiaomin , Yuan Dongmei , Yao Yanwen , Kang Jing , Zhang Jiatao , Zhang Chao , Fu Jianfei , Huang Jianhui , Zhang Yinbin , Sun Pingli , Wang Hong , Ye Mingxiang , Wang Dong , Wang Zhaofeng , Hao Yue , Wang Zhen , Wan Bing , Lv Donglai , Lan Gang , Yang Shengjie , Shi Lin , Wang Yina , Li Bihui , Zhang Zhang , Li Zhongwu , Li Yuan , Liu Zhefeng , Yang Nong , Wang Huijuan , Huang Wenbin , Hong Zhuan , Wang Guansong , Wang Jiandong , Fang Meiyu , Fang Yong , Zhu Xixu , Shen Yi , Zhang Yiping , Ma Shenglin , Song Yong , Lu Yuanzhi , Fang Wenfeng , Li Ziming , Wu Lin 
Published: September 2023

AbstractThe rearranged during transfection (RET) gene is one of the receptor tyrosine kinases and cell‐surface molecules responsible for transmitting signals that regulate cell growth and differentiation. In non‐small cell lung cancer (NSCLC), RET fusion is a rare driver gene alteration associated with a poor prognosis. Fortunately, two selective RET inhibitors (sRETi), namely pralsetinib and selpercatinib, have been approved for treating RET fusion NSCLC due to their remarkable efficacy and safety profiles. These inhibitors have shown the ability to overcome resistance to multikinase inhibitors (MKIs). Furthermore, ongoing clinical trials are investigating several second‐generation sRETis that are specifically designed to target solvent front mutations, which pose a challenge for first‐generation sRETis. The effective screening of patients is the first crucial step in the clinical application of RET‐targeted therapy. Currently, four methods are widely used for detecting gene rearrangements: next‐generation sequencing (NGS), reverse transcription‐polymerase chain reaction (RT‐PCR), fluorescence in situ hybridization (FISH), and immunohistochemistry (IHC). Each of these methods has its advantages and limitations. To streamline the clinical workflow and improve diagnostic and treatment strategies for RET fusion NSCLC, our expert group has reached a consensus. Our objective is to maximize the clinical benefit for patients and promote standardized approaches to RET fusion screening and therapy.
What is work engagement? A text mining approach using employees' self‐narratives
Authors: van Roekel Henrico , Wigger Enno F. J. , Veldkamp Bernard P. , Bakker Arnold B. 
Published: September 2023

AbstractWe introduce text mining to study work engagement by using this method to classify employees' survey‐based self‐narratives into high or low work engagement and analyzing the text features that contribute to the classification. We used two samples, representing the 2020 and 2021 waves of an annual survey among healthcare employees. In the first study, we used exploratory sample 1 (N = 5591) to explore which text features explain work engagement (unigrams, bigrams, psychological, or linguistic). In the second study, we confirmed whether features persisted over time between exploratory sample 1 and confirmatory sample 2 (N = 4470). We find that psychological features classify employees across two samples with 60% accuracy. These features partly validate the literature: High‐engaged employees refer more to affiliation and positive emotions, and low‐engaged employees refer more to negative emotions and power. We extend the literature by studying linguistics: High‐engaged employees use more first‐person plural (“we”) than low‐engaged employees. Finally, some results question the literature, like the finding that low‐engaged employees refer more to their managers. This study shows text mining can contribute by confirming, extending, or questioning the literature on work engagement and explores how future research could build on our findings with survey‐based or in vivo applications.
Compared to antibiotic, feeding peony byproducts can improve growth performance, rumen fermentation, slaughter parameters, and meat quality of lambs
Authors: Zhou Xiaoyang , Xiang Hai , Han Yujie , Chang Xiao , Gu Yue , Liu Zheng'an , Jiao Jinzhen , Fang Yi , Zhong Rongzhen 
Published: September 2023

AbstractOur objective was to determine effects of feeding lamb's peony byproducts, including stem and leaves (PSL), root (PR), and seeds meal (PSM), on growth, rumen fermentation, slaughter parameters, and meat quality. Sixty‐four lambs (14.0 ± 2.1 kg) were allocated into eight treatments based on BW: no additives (CON), 0.15% aureomycin (CONA), low/high levels of PSL (5%/10% PSL replaced 5%/10% Chinese hay), PR (basal diet with 0.5%/1.0% PR), PSM (5%/10% PSM replaced 5%/10% soybean meal). Growth, digestibility, and rumen fermentation had dose responses whereas slaughter parameters, meat quality, or amino acids indexes were not. Peony byproducts increased DMI (p < 0.001) compared to CON, but higher levels were more advantageous (p = 0.003). However, low levels of peony byproducts decreased the NH3‐N concentration, but increased total volatile fatty acids mole percent more than high levels of that (p < 0.001). All peony byproducts increased dressing percentage (p < 0.05), increased pH and tenderness than CON (p < 0.05). In addition, PSL and PSM improved amino acid profiles of meat compared to CON, and were even better than CONA (p < 0.05). Therefore, peony byproducts not only improved animal growth but also reduced the frequency of antibiotic use in animal feeding.
Oral famotidine reduces the plasma level of soluble P‐selectin in children with sickle cell disease
Authors: Allali Slimane , Marquant Fabienne , Rignault‐Bricard Rachel , Taylor Melissa , Brice Joséphine , de Montalembert Mariane , Maciel Thiago Trovati , Elie Caroline , Hermine Olivier 
Published: September 2023

SummaryPlasma histamine levels are increased in patients with sickle cell disease (SCD), potentially promoting endothelial P‐selectin expression and vaso‐occlusion via histamine type 2 (H2) receptors. We conducted a prospective, non‐comparative, single‐centre study to determine whether famotidine, a H2 receptor antagonist, reduces P‐selectin expression in SCD children. The median plasma P‐selectin level was significantly reduced after 29 days of oral famotidine (53.2 ng/mL [IQR: 46.7–63.4] vs. 69.9 ng/mL [IQR: 53.6–84.2], median difference −10.2 ng/mL [IQR: −21.8 to −2.7], p = 0.005) in 28 patients. No effect was observed on other adhesion molecules, inflammation or haemolysis markers, except decreased reticulocyte count. No adverse events deemed related to famotidine were observed. Randomized controlled trials are now needed to assess the efficacy of famotidine in preventing vaso‐occlusion in SCD.
Tumor‐associated astrocytes promote tumor progression of Sonic Hedgehog medulloblastoma by secreting lipocalin‐2
Authors: Li Haishuang , Liu Yuqing , Liu Yantao , Xu Luzheng , Sun Ziwen , Zheng Danfeng , Liu Xiaodan , Song Chen , Zhang Yu , Liang Hui , Yang Bao , Tian Xinxia , Luo Jianyuan , Chang Qing 
Published: September 2023

AbstractSonic Hedgehog (SHH) subgroup of medulloblastoma (MB) accounts for about 25% of all subgroups of MB. Tumor microenvironment (TME) may play a key role in the tumor progression and therapeutic resistance. Tumor‐associated astrocytes (TAAs) are reshaped to drive tumor progression through multiple paracrine signals. However, the mechanism by which TAAs modulate MB cells remains elusive. Here, we illuminated that TAAs showed a specific and dynamic pattern during SHH‐MB development. Most TAAs gathered to the tumor margin during the tumor progression, rather than evenly distributed in the early‐stage tumors. We further demonstrated that lipocalin‐2 (LCN2) secreted by TAAs could promote the tumor growth and was correlated with the poor prognosis of MB patients. Knocking down LCN2 in TAAs in vitro impeded the proliferation and migration abilities of MB cells. In addition, we identified that TAAs accelerated the tumor growth by secreting LCN2 via STAT3 signaling pathway. Accordingly, blockade of STAT3 signaling by its inhibitor WP1066 and AAV‐Lcn2 shRNA, respectively, in TAAs abrogated the effects of LCN2 on tumor progression in vitro and in vivo. In summary, we for the first time clarified that LCN2, secreted by TAAs, could promote MB tumor progression via STAT3 pathway and has potential prognostic value. Our findings unveiled a new sight in reprogramming the TME of SHH‐MB and provided a potential therapeutic strategy targeting TAAs.
A partial agonist of PPARγ prevents paclitaxel‐induced peripheral neuropathy in mice, by inhibiting neuroinflammation
Authors: Benvenutti Larissa , Wolff Fellippe Ramos , Corrêa Thiago Patrício , Melato Jessica , Goldoni Fernanda Capitanio , De Faveri Renata , Patel Yasmin Beatrisse Klein , de Souza Jade André , Grockoski Heloise Adeli , Nilz Paulo Mateus , Bombardelli Cleber Luiz , Remor Aline Pertile , Varela Karina Giacomini , Costa Natáli Tereza Capistrano , Hernandes Marcelo Zaldini , Lacerda Mariella Guimarães , Rodrigues Kathlen Deruci , Milton Flora Aparecida , Neves Francisco de Assis Rocha , Pereira Maria Eduarda Signorini , Kormann Imianowsky Elaine Cristina , de Campos Buzzi Fátima , Brunaldi Marutani Victor Hugo , Stoeberl Luis Carlos , Correa Rogério , Eller Sarah , de Oliveira Tiago Franco , Gonçalves Thamires Bragança Paduam , da Silva Raquel Costa , Passos Giselle Fazzioni , da Costa Robson , Santin José Roberto , Quintão Nara Lins Meira 
Published: September 2023

Background and PurposeChemotherapy‐induced peripheral neuropathy (CIPN) is a common side effect of paclitaxel, affecting 30‐50% of patients. Increased survival and concern with patients' quality of life have encouraged the search for new tools to prevent paclitaxel‐induced neuropathy. This study presents the glitazone 4‐[(Z)‐(2,4‐dioxo‐1,3‐thiazolidin‐5‐ylidene)methyl]‐N‐phenylbenzene‐sulfonamide (TZD‐A1) as a partial agonist of peroxisome proliferator‐activated receptor γ (PPARγ), its toxicological profile and effects on paclitaxel‐induced CIPN in mice.Experimental ApproachInteractions of TZD‐A1 with PPARγ were analysed using in silico docking and in vitro reporter gene assays. Pharmacokinetics and toxicity were evaluated using in silico, in vitro and in vivo (C57Bl/6 mice) analyses. Effects of TZD‐A1 on CIPN were investigated in paclitaxel‐injected mice. Axonal and dorsal root ganglion damage, mitochondrial complex activity and cytokine levels, brain‐derived neurotrophic factor (BDNF), nuclear factor erythroid 2‐related factor 2 (Nrf2) and PPARγ, were also measured.Key ResultsDocking analysis predicted TZD‐A1 interactions with PPARγ compatible with partial agonism, which were corroborated by in vitro reporter gene assays. Good oral bioavailability and safety profile of TZD‐A1 were shown in silico, in vitro and in vivo. Paclitaxel‐injected mice, concomitantly treated with TZD‐A1 by i.p. or oral administration, exhibited decreased mechanical and thermal hypersensitivity, effects apparently mediated by inhibition of neuroinflammation and mitochondrial damage, through increasing Nrf2 and PPARγ levels, and up‐regulating BDNF.Conclusion and ImplicationsTZD‐A1, a partial agonist of PPARγ, provided neuroprotection and reduced hypersensitivity induced by paclitaxel. Allied to its safety profile and good bioavailability, TZD‐A1 is a promising drug candidate to prevent and treat CIPN in cancer patients.
Considering the role of integration experiences in shaping immigrants’ post‐migration food choices and eating practices
Authors: Kwon Eugena 
Published: September 2023

AbstractThis article draws on data collected from qualitative interviews with 38 recent immigrants in two Ontario cities to provide an overview of recent immigrants’ general dietary acculturation experiences. With insights from both Cockerham's health lifestyle theory and Berry's acculturation model, this article explores how structural inequalities related to integration and settlement may shape recent immigrants’ post‐migration food choices and eating practices. The results of this study revealed that immigrants from non‐Western countries experienced greater challenges in healthy eating. Findings are in line with Cockerham's health lifestyle theory: immigrants’ post‐migration food choices and dietary acculturation strategies were not only bounded by socioeconomic status and cultural differences but were also shaped by various structural inequalities, especially those related to systematic barriers during the integration and settlement process. Overall, this paper provides a more holistic understanding of the multifaceted nature of immigrants’ dietary acculturation experiences.