bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-treatment nutrition-related indicators and the prognosis of patients with newly diagnosed epithelial ovarian cancer: an ambispective cohort study
Authors: Wang Shirui , Zhu Jingyu , Wu Ningjuan , Wang Nannan , Dang Xiaohe , Zhao Minyi , Zhao Juan , Ma Ding , Yang Xiaofeng 
Published: January 2025

BackgroundFew studies have explored the link between nutritional status and prognosis in patients with epithelial ovarian cancer (EOC), and existing findings are controversial. Thus, this study aimed to explore the effects of pre-treatment nutrition-related indicators on the prognosis of patients with newly diagnosed EOC.MethodsIn this ambispective cohort study, 1,020 patients with EOC diagnosed by pathology examination were enrolled and followed-up until December 31, 2023. Univariate and multivariable analyses were conducted on nutrition-related indicators, including body mass index (BMI), albumin (ALB), hemoglobin (Hb), diabetes mellitus (DM), and hyperlipidemia, along with clinicopathological characteristics that might affect patients’ first-line chemotherapy response, progression-free survival (PFS), and overall survival (OS). Survival curves were created using the Kaplan–Meier method. A Cox proportional hazards model was established to obtain hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsThe median follow-up duration was 48 months. Compared with patients having normal nutritional indicators, those with hypoalbuminemia had poorer first-line chemotherapy responses. The proportions of those with complete response (CR), partial response (PR), and stable disease or progressive disease (SD/PD) for the ≤30 g/L, 30 &lt; ALB&lt;35 g/L and normal ALB groups were 57.2, 20.6, and 22.2% vs. 62.0, 22.5, and 15.5% vs.79.5, 13.6, and 6.9%. Patients with hypoalbuminemia had shorter median PFS (mPFS): 15 vs. 19 vs. 57 months in the three groups, respectively; and shorter median OS (mOS): 36 vs. 51 vs. 124 months. Patients with hyperlipidemia also exhibited poorer first-line chemotherapy responses; CR, PR, and SD/PD rates for the hyperlipidemia and non-hyperlipidemia groups were 68.9, 19.5, and 11.6% vs. 76.4, 14.7, and 8.9%, respectively, and shorter mPFS (17 vs. 57 months) and mOS (40 vs. 119 months). Patients with anemia had poorer first-line chemotherapy responses; CR, PR, and SD/PD rates for the anemia and non-anemia groups were 68.4, 19.7, and 11.9% vs. 76.2, 14.9, and 8.9%, respectively. All differences were statistically significant (p &lt; 0.05). Multivariable analysis identified hyperlipidemia as an independent risk factor for PFS (hazard ratio [HR] = 2.083; 95% CI:1.726–2.514; p &lt; 0.001) and OS (HR = 2.158; 95% CI:1.746–2.666; p &lt; 0.001), whereas hypoalbuminemia and anemia were not confirmed as independent prognostic factors. This study found no effect of BMI or DM on patient prognosis.ConclusionPre-treatment hypoalbuminemia, hyperlipidemia, and anemia negatively affected the prognosis of patients with newly diagnosed EOC, with hyperlipidemia being an independent risk factor for shorter survival.
Association between oxidative balance score and glaucoma in the National Health and Nutrition Examination Survey
Authors: Huang Jun , Zhang Yulan , Wu Chao , Wu Yifan , Wang Feiran , Ning Yunxuan , Shi Lu 
Published: January 2025

ObjectiveTo investigate the association between Oxidative Balance Score (OBS) and glaucoma risk.MethodsUsing data from the National Health and Nutrition Examination Survey (2005–2008), we analyzed 2,615 participants aged ≥40 years. OBS was calculated from 15 antioxidant and 5 pro-oxidant components, including dietary nutrients and lifestyle factors. Glaucoma was identified through self-reported diagnosis and retinal imaging. Survey-weighted logistic regression and restricted cubic splines (RCS) were used to assess associations.ResultsHigher OBS was associated with lower glaucoma risk (adjusted OR = 0.97, 95% CI: 0.94–1.00). Participants in the highest OBS quartile showed 51% lower odds of glaucoma compared to the lowest quartile (adjusted OR = 0.49, 95% CI: 0.27–0.90). The protective effect was more pronounced among middle-aged adults (40–60 years; OR = 0.90, 95% CI: 0.86–0.95) and males (OR = 0.93, 95% CI: 0.90–0.97).ConclusionHigher OBS were associated with lower glaucoma prevalence, particularly among middle-aged adults and males, suggesting potential benefits of maintaining oxidative balance in glaucoma prevention.
MRI-based intratumoral and peritumoral radiomics for assessing deep myometrial invasion in patients with early-stage endometrioid adenocarcinoma
Authors: Yang Jing , Liu Yang , Liu Xiaolong , Wang Yaoxin , Wang Xianhong , Ai Conghui , Bi Qiu , Zhao Ying 
Published: January 2025

PurposeTo evaluate the effectiveness of magnetic resonance imaging (MRI)-based intratumoral and peritumoral radiomics models for predicting deep myometrial invasion (DMI) of early-stage endometrioid adenocarcinoma (EAC).MethodsThe data of 459 EAC patients from three centers were retrospectively collected. Radiomics features were extracted separately from the intratumoral and peritumoral regions expanded by 0 mm, 5 mm, and 10 mm on unimodal and multimodal MRI. Then, various radiomics models were developed and validated, and the optimal model was confirmed. Integrated models were constructed by ensemble and stacking algorithms based on the above radiomics models. The models’ performance was evaluated using the area under the curve (AUC).ResultsThe multimodal MRI-based radiomics model, which included both intratumoral and peritumoral regions expanded by 5 mm, was the optimal radiomics model, with an AUC of 0.74 in the validation group. When the same integrated algorithm was utilized, the integrated models with 5-mm expansion presented higher AUCs than those with 0-mm and 10-mm expansion in the validation group. The performance of the stacking model and ensemble model with 5-mm expansion was similar, and their AUCs were 0.74 and 0.75, respectively.ConclusionThe multimodal radiomics model from the intratumoral and peritumoral regions expanded by 5 mm has the potential to improve the performance for detecting DMI of early-stage EAC. The integrated models are of little value in increasing the prediction.
Case Report: Diagnosis and treatment of incontinentia pigmenti with central nervous system anomalies in one patient
Authors: Li Yun , Hong Junbin , Xu Shangge , Zhou Tong , Xiao Xiaolan , Yang Jinghua , Chen Yiting 
Published: January 2025

IntroductionThis article reports a detailed case of a patient with incontinentia pigmenti who exhibited epileptic status and dermatologic symptoms.Case presentationA 5-month-old female patient was brought to our hospital due to status epilepticus, with erythematous vesicular skin lesions on her trunk and extremities. Routine magnetic resonance imaging revealed infarction, ischemia, and encephalomalacia. Skin biopsy pathology indicated pigmentation disorder. Molecular genetic testing was conducted to identify IKBKG mutations, and the case was finally diagnosed with incontinentia pigmenti complicated by central nervous system anomalies. She was treated with oral levetiracetam (10 mg/kg/day, administered every 12 h) to control her recurrent seizures, and prednisone (1 mg/kg/day, once a day) for anti-inflammatory effects.ConclusionAfter nine months, her skin lesions have resolved, with only a few newly developed erythematous papules and areas of hyperpigmentation being evident. There were no recurrent epilepsy symptoms, developmental impairments, or other associated symptoms.
Parishin B blocking TRIB3-AKT1 interaction inhibits breast cancer lung metastasis
Authors: Cheng Xiongtao , Sun Jianguo , Chen Shouhong , Wang Nan , Tang Weijing , Xia Zijian , Shu Yuhong , Gao Shouhong , Wang Zhipeng , Wang Xinxia , Shao Rongzi , Cao Jianxiong 
Published: January 2025

BackgroundTRIB3 has been reported to mediate breast cancer (BC) proliferation and metastasis by interacting with AKT1, and blocking the interaction between TRIB3 and AKT1 can inhibit the progression of BC. Besides, inhibiting TRIB3 to turn “cold tumor” hot has also been proved to be an effective therapeutic strategy for BC. Thus, this study aim to find drugs that can bind to TRIB3 to inhibit BC progression, and further elucidate its mechanism.MethodsThe possible inhibitors of TRIB3 were screened by high-throughput molecular docking, CETSA, and CO-IP assay. Then, the effect of TRIB3 inhibitor anti BC was assessed by CCK-8 assay, flow cytometry, plate colony formation assay, and transwell assay; and the RNA-seq was empolyed to study the potential mechanism of Parishin B (PB) anti-BC. Finally, the effect of TRIB3 inhibitor on BC lung metastasis in vivo was evaluated.ResultsPB was screened as a possible inhibitor of TRIB3, and CETSA and CO-IP assay indicated that PB could target TRIB3 and block TRIB3-AKT1 interaction. In addition, PB exhibited good anti-BC activity without drug toxicity in normal breast cells by experiments in vitro, and RNA-seq analysis suggested PB could inhibit the proliferation and invasion of BC cells related with cell cycle. It was also proved that PB could inhibit BC lung metastasis in vivo.ConclusionThe study demonstrated PB can bind to TRIB3 to inhibit BC proliferation and lung metastasis by blocking TRIB3-AKT1 interaction and regulating cell cycle, providing a therapeutic agent for the treatment of BC.
Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study
Authors: Liu Yuan , Ouyang Jianjie , Zhang Cuicui , Niu Pingping , Shang Baoling , Yao Gengzhen , Shi Yongyong , Zou Xu 
Published: January 2025

BackgroundThe efficacy of dexmedetomidine (DEX) in treating sepsis-induced myocardial injury (SIMI) remains unclear. In this study, we explored the relationship between DEX use and clinical outcomes of patients with SIMI, focusing on the dosage and treatment duration.MethodsIn this retrospective cohort analysis, we identified patients with SIMI from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database and categorized them into the DEX and non-DEX groups based on intensive care unit treatment. The baseline bias was reduced through propensity score matching (PSM). The primary outcome was 28-day mortality, whereas the secondary outcomes were in-hospital mortality and mortality rates at 7 days, 90 days, and 1 year. The association between DEX use and in-hospital mortality was assessed using Kaplan–Meier analysis and Cox proportional hazards models.ResultsAfter PSM, 373 patients in the DEX group were matched with 579 patients in the non-DEX group to achieve a balanced distribution of the covariates. The Cox regression model demonstrated a significant reduction in the 28-day mortality associated with DEX use, yielding a hazard ratio (HR) of 0.61 (95% confidence interval [CI]: 0.47–0.78, P &lt; 0.001). In-hospital mortality also significantly decreased (HR = 0.43, 95% CI: 0.33–0.57, P &lt; 0.001). Lower mortality rates were observed at 7 days, 90 days, and 1 year. DEX doses &gt;0.4 μg/kg/h, particularly in the range of 0.400–0.612 μg/kg/h, total doses &gt;3.113 mg during hospitalization, and treatment durations exceeding 72 h were associated with improved mortality risk at all intervals. Regarding DEX efficacy at 28 days, our subgroup analyses indicated a significant interaction between the Sequential Organ Failure Assessment score and invasive mechanical ventilation.ConclusionDEX administration was associated with improved in-hospital mortality and reduced mortality rates at 7 days, 28 days, 90 days, and 1 year in patients with SIMI. These findings require validation in future studies.
Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction
Authors: Zhang Jing J. , Rizk Rodrigue , Li Xiaoping , Lee Brandon G. , Matthies Mason L. , Bietz Kennedy A. , Kim Kang , Huard Johnny , Wang Yadong , Chen William C. W. 
Published: January 2025

IntroductionInterleukin-10 (IL-10) is a potent immunomodulatory cytokine widely explored as a therapeutic agent for diseases, including myocardial infarction (MI). High-dose IL-10 treatment may not achieve expected outcomes, raising the question of whether IL-10 has dose-dependency, or even uncharted side-effects from overdosing. We hypothesized that IL-10 has dose-dependent effects on macrophage (Mφ) phenotypic transition and cardiac remodeling after MI.MethodsUsing RAW264.7 monocyte models, we examined whether administering differential doses of exogenous IL-10 (0–1,000 ng/mL) perturbs classic M1 (pro-inflammatory) and M2 (anti-inflammatory) phenotypes of polarized Mφ or even alters the phenotypic transition of prospective M1 and M2 polarization. We then investigated the impact of single intramyocardial IL-10 administration on cardiac function, structure, and inflammation post-MI, using a mouse MI model.ResultsCompared with 0-ng/mL control, 250-ng/mL IL-10 had the strongest overall effects in decreasing M1 and increasing M2 phenotypes on polarized Mφ while ≥500-ng/mL IL-10 dampened M1 polarization and augmented native IL-10 secretion more effectively than low doses in vitro. Echocardiography revealed that the 250-ng group had consistently higher contractile function and lower left ventricular (LV) dilatation than the saline control over 6 weeks while ≥1,000-ng groups exhibited transient lower LV ejection fraction at 5 days post-MI in vivo. Moreover, different doses of IL-10 differentially modulated myocardial gene expression, phagocytic cell infiltration at the infarct, LV fibrosis, and revascularization post-MI, with some, but not all, doses exerting beneficial effects.DiscussionOur study suggested that IL-10 has an effective dose range on Mφ phenotypes, and intramyocardial IL-10 treatment may trigger cardioprotective or unwanted effects post-MI in a dose-dependent manner.
Chronic fetal hypoxia and antenatal Vitamin C exposure differentially regulate molecular signalling in the lung of female lambs in early adulthood
Authors: McGillick Erin V. , Orgeig Sandra , Allison Beth J. , Brain Kirsty L. , Bertossa Melanie R. , Holman Stacey L. , Meakin Ashley S. , Wiese Michael D. , Niu Youguo , Itani Nozomi , Skeffington Katie L. , Beck Christian , Botting-Lawford Kimberly J. , Morrison Janna L. , Giussani Dino A. 
Published: January 2025

IntroductionChronic fetal hypoxia is commonly associated with fetal growth restriction and can predispose to respiratory disease at birth and in later life. Antenatal antioxidant treatment has been investigated to overcome the effects of oxidative stress in utero to improve respiratory outcomes. We aimed to determine if the effects of chronic fetal hypoxia and antenatal antioxidant administration persist in the lung in early adulthood.MethodsChronically catheterised pregnant sheep were exposed to normoxia (N; n = 20) or hypoxia (H; n = 18; 10% O2) ± maternal daily i. v. saline (N = 11; H = 8) or Vitamin C (VC; NVC = 9; HVC = 10) from 105 to 138 days (term, ∼145 days). Lungs were collected from female lambs 9 months after birth (early adulthood). Lung tissue expression of genes and proteins regulating oxidative stress, mitochondrial function, hypoxia signalling, glucocorticoid signalling, surfactant maturation, inflammation and airway remodelling were measured.ResultsChronic fetal hypoxia upregulated lung expression of markers of prooxidant, surfactant lipid transport and airway remodelling pathways in early adulthood. Antenatal Vitamin C normalized prooxidant and airway remodelling markers, increased endogenous antioxidant, vasodilator and inflammatory markers, and altered regulation of hypoxia signalling and glucocorticoid availability.ConclusionThere are differential effects of antenatal Vitamin C on molecular markers in the lungs of female lambs from normoxic and hypoxic pregnancy in early adulthood.
A comparative evaluation of antibiotic and synbiotic supplementation on production performance and necrotic enteritis severity in broilers during an experimental necrotic enteritis challenge
Authors: Shah Bikas Raj , Al Hakeem Walid Ghazi , Shanmugasundaram Revathi , Selvaraj Ramesh K. 
Published: January 2025

The ban on antibiotics in the poultry diet resulted in re-emergence of several infectious diseases including necrotic enteritis (NE). These infectious diseases are leading to poor health and welfare as well as production and economic loss. Synbiotic could be a potential candidate to replace the antibiotics in poultry diet. Therefore, a 35-day study was conducted to compare the efficacy of synbiotic (PoultryStar®ME) and antibiotic (Stafac®50, Virginiamycin) supplementation during an experimentally induced necrotic enteritis infection. A total of 360 day-old chicks were randomly assigned to four treatment groups: Antibiotic, Challenge + Antibiotic, Synbiotic, and Challenge + Synbiotic, each with 6 replicates. The treatment groups referred as “Challenge + Antibiotic” and “Challenge + Synbiotic” were challenged, while their respective non-challenged treatment groups were “antibiotic” and “synbiotic”. NE in birds was induced by gavaging 1 × 104 oocysts of Eimeria maxima on day 14 (D14) and 1 × 108 CFU/mL of Clostridium perfringens on D19, 20, and 21. Both synbiotic and antibiotic supplementation during the NE challenge did not improve BW gain, feed intake, and feed conversion ratio at the end of the experiment (D0-35). However, antibiotic supplementation reduced mortality during the week of the challenge (D14-21) (P &lt; 0.001). At D21, both synbiotic and antibiotic supplementation during the NE challenge did not decrease the intestinal lesion score (P &lt; 0.001) compared to their respective non-challenged treatment groups. At D21, synbiotic supplementation during the NE challenge did not decrease intestinal permeability (P = 0.04) compared to the synbiotic group. At D21, antibiotic supplementation during the NE challenge increased the CD4+:CD8+ T cells (P &lt; 0.001) in the cecal tonsil. It can be concluded that synbiotic supplementation elicited an immune response, decreasing the inflammatory response in the intestine and ameliorating the NE infection. Therefore, synbiotic could be a potential alternative to replace antibiotics in the poultry industry, but their efficacy needs to be improved through blending additional probiotics and prebiotics, and further exploration is required.
Internet use and attitude toward aging among Chinese older adults: the mediating role of health
Authors: Wang Xuehui 
Published: January 2025

ObjectivesThis research seeks to explore the relationship between Internet use and attitudes toward aging among older adults in China, with a particular emphasis on the mediating role of health in this correlation.MethodsA national survey of 10,858 Chinese adults aged 60 and above was conducted, employing multiple linear regression and structural equation modeling to analyze the impact of Internet use on aging attitudes with health as a mediator.ResultsThe research found a significant positive association between Internet use and positive aging attitudes (β = −1.420, p &lt; 0.001). Health indicators—self-rated, physical, and mental health—were identified as key moderators, with healthier adults benefiting more from Internet use.ConclusionThis research reveals a positive association between Internet use and attitudes toward aging among older adults in China. These findings hold substantial implications for encouraging active and healthy aging in the digital era, underscoring the value of advocating for digital engagement among seniors as a means to improve their quality of life.
Factors influencing type 2 diabetes self-management practices in rural Bangladesh: a qualitative investigation
Authors: Chowdhury Hasina Akhter , Billah Baki , Dipa Shamia Akther , Kabir Ashraful , Rahman A. K. M. Fazlur , Ali Liaquat , Joham Anju E. , Harrison Cheryce L. 
Published: January 2025

IntroductionType 2 diabetes mellitus (T2DM) is a prevalent, chronic health condition of global significance, with low- and middle-income countries (LMICs) disproportionately affected. Diabetes self-management practices (DSMP) are the gold-standard treatment approach, yet uptake remains challenge in LMICs.Purpose of the studyThis study aimed to explore the barriers to and facilitators of DSMP and preferences for intervention design and delivery in Bangladesh, an LMIC, with prevalent T2DM.MethodsSixteen qualitative focus group discussions (FGDs) with adults with T2DM and their caregivers were conducted in rural Bangladesh to explore preferences, barriers, and facilitators for community DSMP-related intervention programs. Data were thematically analyzed using a deductive theoretical domains framework (TDF) underpinned by the socio-ecological model.ResultsOverall, 117 participants (n = 58 with T2DM and n = 59 caregivers) were included in the analysis. Five overarching themes were identified, including (i) implementation of DSMP, (ii) community spirit and interconnectedness, (iii) environmental influences, (iv) healthcare professionals’ role in DSMP, and (v) government support. Key barriers to DSMP identified for T2DM patients include knowledge implementation gaps, cultural practices, limited resources, and financial constraints. Facilitators include motivation, support from family and peers, and religious practices. Rural Bangladeshis prefer programs delivered at community clinics, viewing them as reliable, culturally appropriate central ‘hubs’ to assemble.ConclusionBarriers to and facilitators of DSMP were identified, and preferences for intervention design and delivery for implementing DSMP were explored. The findings provide a foundation for the critical need to implement programs that improve DSMP in Bangladesh, with the potential to translate to other LMIC settings.
Construction and validation of a prediction model for fall risk in hospitalized older adults with osteoporosis
Authors: Sun Li , Gu Hai-Yan , Xu Guan-Hua , Jiang Jia-Wei , Wang Ting-Ting , Li Dan-Dan , Cui Bai-Hong 
Published: January 2025

ObjectiveThe aim of this study is to develop and validate a prediction model for fall risk factors in hospitalized older adults with osteoporosis.MethodsA total of 615 older adults with osteoporosis hospitalized at a tertiary (grade 3A) hospital in Nantong City, Jiangsu Province, China, between September 2022 and August 2023 were selected for the study using convenience sampling. Fall risk factors were identified using univariate and logistic regression analyses, and a predictive risk model was constructed and visualized through a nomogram. Model performance was evaluated using the area under the receiver operator characteristic curve (AUC), Hosmer-Lemeshow goodness-of-fit test, and clinical decision curve analysis, assessing the discrimination ability, calibration, and clinical utility of the model.ResultsBased on logistic regression analysis, we identified several significant fall risk factors for older adults with osteoporosis: gender of the study participant, bone mineral density, serum calcium levels, history of falls, fear of falling, use of walking aids, and impaired balance. The AUC was 0.798 (95% CI: 0.763–0.830), with a sensitivity of 80.6%, a specificity of 67.9%, a maximum Youden index of 0.485, and a critical threshold of 121.97 points. The Hosmer-Lemeshow test yielded a χ2 value of 8.147 and p = 0.419, indicating good model calibration. Internal validation showed a C-index of 0.799 (95% CI: 0.768–0.801), indicating the model’s high discrimination ability. Calibration curves showed good agreement between predicted and observed values, confirming good calibration. The clinical decision curve analysis further supported the model’s clinical utility.ConclusionThe prediction model constructed and verified in this study was to predict fall risk for hospitalized older adults with osteoporosis, providing a valuable tool for clinicians to implement targeted interventions for patients with high fall risks.