bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reference percentiles for tri‐ponderal mass index and its association with general and abdominal obesity among Iranian children and adolescents: A report from the SHED LIGHT study
Authors: Tabib Avisa , Samiei Niloufar , Ghavidel Alireza A. , Bakhshandeh Hooman , Noohi Feridoun , Hosseini Saeid , Rezaei Yousef 
Published: February 2023

AbstractBackgroundThe body mass index (BMI) has some limitations in identifying obesity, particularly among children and adolescents.ObjectivesWe sought to determine the reference percentiles of tri‐ponderal mass index (TMI) for Iranian population, and its relation to BMI, waist circumference (WC), and waist circumference‐to‐height ratio (WHtR).MethodsBaseline characteristics for 14 641 children and adolescents were applied. The area under the characteristics (AUC) curve and optimal cut‐off points for TMI were used to define the accuracy of TMI for discriminating general and central obesity compared to other anthropometric measurements.ResultsTMI levels remained stable from 6 to 18 years with a small range of difference. The highest AUCs for discriminating obesity according to BMI and WHtR ≥0.5 from non‐obese subjects were related to TMI (0.980) and TMI (0.912), respectively, and these findings were similar for both sexes. Moreover, the AUC for TMI to discriminate central obesity by WHtR was higher than that for BMI (0.912 vs. 0.833, p < .001), and this difference was similar among sex and age groups. The optimal value of TMI for discriminating general obesity, obesity by WC, and obesity by WHtR were 15.2 (sensitivity 96.2 and specificity 89.8), 15 (sensitivity 86.9 and specificity 79.9), and 13.9 (sensitivity 85.1 and specificity 81.5), respectively.ConclusionsTMI discriminated central obesity by WHtR more accurately than obesity by BMI among Iranian children and adolescents irrespective of sex. Besides it remained relatively constant across age‐ and sex‐specific groups providing a single optimal cut‐off point for screening obesity during childhood and adolescence.
Intraspecific Variation in the Terpene Profiles of Dodonaea viscosa
Authors: Dutra‐Nobre Adriana R. , Olivier Wesley J. , Deans Bianca J. , Kilah Nathan L. , Alejandro Fernando Maya , Smith Jason A. , Bissember Alex C. 
Published: February 2023

AbstractNatural products isolation studies were performed on Dodonaea viscosa plant individuals sampled across seven different populations, which revealed considerable intraspecific variation in the terpene profiles across D. viscosa. In total, 14 ent‐labdane diterpenoids (seven of which are previously unreported), four ent‐kauranes (one which is previously unreported), one rare norhopene, and two previously unreported monoterpenoid wax esters were isolated. Exceedingly few terpene wax esters have been reported in Nature and the isolation of these unusual secondary metabolites is particularly notable for this reason. In each case, the proposed structures were elucidated employing various standard one‐ and two‐dimensional NMR (1H, 13C, NOESY, COSY, HSQC, HMBC) spectroscopic techniques and complemented by IR spectroscopy, mass spectrometry, and polarimetry, where appropriate. Synthetic derivatization and X‐ray crystallographic analysis were also employed to further support or secure structural assignments.
Associations of potential ADRD plasma biomarkers in cognitively normal volunteers
Authors: Estepp Taylor G. , Charnigo Richard J. , Abner Erin L. , Jicha Gregory A. , Sudduth Tiffany L. , Fardo David W. , Wilcock Donna M. 
Published: February 2023

AbstractINTRODUCTIONThis study examined the relationships between 13 novel blood‐plasma biomarkers and dementia‐related demographic and health factors in a cohort of 237 cognitively normal research volunteers whose average age was ≈82 years and who were 63% female.METHODSWe regressed each biomarker on selected covariates to explore the associations between the biomarkers and selected factors to assess whether they may contribute to biomarker values. Post hoc sensitivity analyses were done with updated data and consistent variable sets for robustness and batch effects.RESULTSBiomarker concentrations were largely not associated with demographics or health conditions, but some expected associations (e.g., apolipoprotein E [APOE] status with amyloid beta [Aβ]42/Aβ40) were observed. Post hoc results remained similar to those of the main analysis.DISCUSSIONThe absence of strong associations between the biomarkers with age, gender, or medical conditions suggests that changes in these biomarkers, when observed, may be attributable to neuropathological changes.Highlights
Among N = 237 cognitively normal adults, we studied candidate Alzheimer's disease and related dementia (ADRD) plasma biomarkers.
Biomarkers were largely not associated with demographic or health factors.
Apolipoprotein E (APOE) status was associated with amyloid beta (Aβ)42/Aβ40 ratio.
These results support hypotheses that plasma biomarkers are informative for ADRD.
Hybrid Acid/alkali All Covalent Organic Frameworks Battery
Authors: Xu Yunpeng , Cai Pingwei , Chen Kai , Chen Qingsong , Wen Zhenhai , Chen Long 
Published: February 2023

AbstractCovalent organic frameworks (COFs), thanks to their adjustable porous structure and abundant build‐in functional motifs, have been recently regarded as promising electrode materials for a variety of batteries. There still remain grand opportunities to further utilizing their merits for developing advanced COFs‐based batteries. In this paper, we propose a hybrid acid/alkali all‐COFs battery by coupling pyrene‐4,5,9,10‐tetraone based COF cathode with anthraquinone based COF anode. In such a hybrid acid/alkali all‐COFs battery, the cathodic COF favorably works in acid with a relatively positive potential, while the anodic COF preferably runs in alkali with a relatively negative potential. It thus can deliver a decently high discharge capacity of 92.97 mAh g−1with a wide voltage window of 2.0 V, and exhibit high energy density of 74.2 Wh kg−1along with a considerable cyclic stability over 300 cycles. The development of the proof‐of‐concept all‐COFs battery may drive forward the improvement of newly cost‐effective and performance‐reliable energy storage devices.
Systematic Enzymatic Synthesis of dTDP‐Activated Sugar Nucleotides
Authors: Wei Fangyu , Yuan Rui , Wen Qin , Wen Liuqing 
Published: February 2023

AbstractDeoxythymidine diphosphate (dTDP)‐activated sugar nucleotides are the most diverse sugar nucleotides in nature. They serve as the glycosylation donors of glycosyltransferases to produce various carbohydrate structures in living organisms. However, most of the dTDP‐sugars are difficult to obtain due to synthetic difficulties. The limited availability of dTDP‐sugars has hindered progress in investigating the biosynthesis of carbohydrates and exploring new glycosyltransferases in nature. In this study, based on the de novo and salvage biosynthetic pathways, a variety of dTDP‐activated sugar nucleotides were successfully prepared in high yields and on a large scale from readily available starting materials. The produced sugar nucleotides could provide effective tools for fundamental research in glycoscience.
Ferroptosis Detection: From Approaches to Applications
Authors: Zeng Fantian , Nijiati Sureya , Tang Longguang , Ye Jinmin , Zhou Zijian , Chen Xiaoyuan 
Published: February 2023

AbstractUnderstanding the intricate molecular machinery that governs ferroptosis and leveraging this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, and prognosis. Emerging approaches for the in situ detection of the major regulators and biological events across cellular, tissue, and in living subjects provide a multiscale perspective for studying ferroptosis. Furthermore, advanced applications that integrate ferroptosis detection and the latest technologies hold tremendous promise in ferroptosis research. In this review, we first briefly summarize the mechanisms and key regulators underlying ferroptosis. Ferroptosis detection approaches are then presented to delineate their design, mechanisms of action, and applications. Special interest is placed on advanced ferroptosis applications that integrate multifunctional platforms. Finally, we discuss the prospects and challenges of ferroptosis detection approaches and applications, with the aim of providing a roadmap for the theranostic development of a broad range of ferroptosis‐related diseases.
Anticooperative Supramolecular Oligomerization Mediated by V‐Shaped Monomer Design and Unconventional Hydrogen Bonds
Authors: Matarranz Beatriz , Díaz‐Cabrera Sandra , Ghosh Goutam , Carreira‐Barral Israel , Soberats Bartolome , García‐Valverde María , Quesada Roberto , Fernández Gustavo 
Published: February 2023

AbstractAfter more than three decades of extensive investigations on supramolecular polymers, strategies for self‐limiting growth still remain challenging. Herein, we exploit a new V‐shaped monomer design to achieve anticooperatively formed oligomers with superior robustness and high luminescence. In toluene, the monomer‐oligomer equilibrium is shifted to the monomer side, enabling the elucidation of the molecular packing modes and the resulting (weak) anticooperativity. Steric effects associated with an antiparallel staircase organization of the dyes are proposed to outcompete aromatic and unconventional B−F⋅⋅⋅H−N/C interactions, restricting the growth at the stage of oligomers. In methylcyclohexane (MCH), the packing modes and the anticooperativity are preserved; however, pronounced solvophobic and chain‐enwrapping effects lead to thermally ultrastable oligomers. Our results shed light on understanding anticooperative effects and restricted growth in self‐assembly.
Enantioselective Synthesis of Bromodifluoromethyl‐containing Oxazolines by Concerted Lewis/Brønsted Base Catalysis with Chiral Bisphosphine Oxide
Authors: Hirokawa Ryo , Nakahara Yuki , Uchida Shotaro , Yamashita Kenji , Hamashima Yoshitaka 
Published: February 2023

AbstractWe describe regio‐ and enantioselective bromocyclization of difluoroalkenes catalyzed by chiral bisphosphine oxides. Owing to the simultaneous activation of both the brominating reagent and amide substrate, the desired cyclization reaction proceeds smoothly even at low temperature to provide bromodifluoromethyl‐containing oxazolines with a chiral quaternary center in a highly enantioselective fashion (up to 99% ee). This protocol features the use of commercially available brominating reagents and readily accessible chiral catalysts. The regioselectivity and enantioselectivity are influenced by the catalyst structure, the brominating reagent, and the reaction temperature. Under the optimal conditions, 5‐exo cyclization proceeds preferentially compared with 6‐endo cyclization, depending on the electronic properties of the alkene substrates. A gram‐scale synthesis of chiral oxazoline was achieved with as little as 1 mol % of the catalyst.
Cross‐replicating findings on unique motor impairments of children with ASD using confirmatory factor analysis and a novel SPARK study sample
Authors: Bhat Anjana , Tulsky David S. , Boulton Aaron J. 
Published: February 2023

AbstractA series of recent reports have shed light on the pervasive nature of motor impairments in children with ASD (Bhat, 2020, 2021, Bhat et al., 2022), underscoring the importance of providing ASD clinicians efficient and accurate tools for motor screening. The Developmental Coordination Disorder‐Questionnaire (DCD‐Q) is a widely used motor screening tool, yet scant evidence exists regarding its psychometric properties in children with ASD. In a recent Exploratory Factor Analysis (EFA) of the 15‐item DCD‐Q in a large sample of children with ASD (SPARK study), we found a 5‐factor latent structure that identified unique motor impairments in a large sample of children with ASD (Bhat et al., 2022). In the current study, we extend this work by cross‐replicating the EFA findings of unique ASD‐related motor issues using Confirmatory Factor Analysis (CFA) in a new, more recent wave of children with ASD from the SPARK study (N = 9721). The fits and interpretability of 11 hypothesis‐driven CFA models, including 8 correlated‐factors, 1 second‐order, and 2 bifactor models were compared. Our findings supported the previous 5‐factor model with 2 gross motor subdomains, 1 fine motor domain (similar to the original DCD‐Q) and 2 general coordination subdomains. This model demonstrated acceptable fit in the new sample as well as superior fit compared to several other parsimonious correlated‐factors models. However, the second‐order and bifactor models fit slightly better and supported the presence of a general motor skills factor, although 38% of the common variance in the DCD‐Q items remained attributable to the 5 subdomains. Using one of the bifactor models, measurement invariance was also supported for DCD‐Q across sex, race, and co‐occurring conditions of language disorder and intellectual disability. Only partial invariance was supported when testing DCD‐Q scores across different age groups. These findings reveal a more complex dimensional picture of the DCD‐Q in children with ASD. Results suggest that the DCD‐Q can be used in two ways, total scores adequately assess general motor skills for brief screening and subdomain scores offer unique information on the multidimensional motor problems of children with ASD. If subdomain data are of interest, our findings call into question the practice of relying on 3 original subscales of the DCD‐Q when screening for ASD‐related motor difficulties, whereas 4 out of 5 subscale scores may better highlight domain‐specific motor problems. Future studies should continue to further validate DCD‐Q's ability to screen for multidimensional motor problems.
Biological potential of polysaccharides extracted from Nostoc colonies for film production – Physical and biological properties
Authors: Jasińska Joanna Maria , Kamińska Iwona , Chmiel Maria J. , Jamróz Ewelina 
Published: February 2023

AbstractCyanobacteria of the Nostoc genus secrete a number of biologically active compounds, including polysaccharides, which may exhibit antioxidant, antimicrobial, anticancer, and anti‐inflammatory properties. The aim of the study was to investigate the biological properties of Nostoc polysaccharides (NPs) (antioxidative and antimicrobial) and the possibility of using NPs addition in the production of biofoils. Our results allow to indicate that NPs were compatible with the used biopolymer matrix (furcellaran and chitosan) and showed antioxidant properties. The tested polysaccharide extracts (0.14%) exhibited the ability to neutralize free radicals – 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) at a level of 4.46% and 10.14%, respectively. NP extracts demonstrated reducing properties of 15.35 and 30.07 mg Trolox equivalents (FRAP and CUPRAC methods, respectively) and 2.64 mg chlorogenic acid equivalents (tested with Folin's reagent). NP extracts showed: a growth‐stimulating effect (Escherichia coli, Staphylococcus aureus, and Saccharomyces cerevisiae), no effect (Penicillum sp.), or a slight inhibitory effect (Streptomyces sp.) on the tested microorganisms. The enrichment of the film with NPs influenced the physic‐chemical properties of the obtained biofoils. The addition of polysaccharides to furcellaran and chitosan films decreased their water solubility (by approximately 40% and 9%, respectively, compared to the control) and, at the same time increased, their water absorption.
Intelligent micro/nanorobots for improved tumor therapy
Authors: Sun Zhaoli , Hou Yanglong 
Published: February 2023

AbstractA major bottleneck underlying nanomaterial‐based tumor therapy lies in complex biological environment and physiological barriers. Micro/nanorobots with the features of self‐propulsion and controllable navigation have gradually become a research hotspot in the tumor therapeutic community, exhibiting their advantages in efficient cargo loading, controllable cargo delivery, stimuli‐triggered cargo release, deeper tumor tissue penetration, and enhanced cargo accumulation in tumor tissue. In this review, the self‐propulsion and controllable navigation are introduced as two major properties of micro/nanorobots, in which micro/nanorobots are propelled by chemical reactions, physical fields, and biological systems and could be navigated by chemotaxis, remote magnetic guidance, and light. Then, the recent advances of micro/nanorobots for chemotherapy, immunotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, and multimodal tumor therapy would be discussed. Finally, the perspective and challenges are also mentioned. It is expected that this review gives an insight into intelligent micro/nanorobots for improved tumor therapy, aiming for more extensive and in‐depth investigations, and final applications in the clinic.
Gender and sex in eating disorders: A narrative review of the current state of knowledge, research gaps, and recommendations
Authors: Breton Édith , Juster Robert‐Paul , Booij Linda 
Published: February 2023

AbstractIntroductionEating disorders (EDs) have long been considered conditions exclusively affecting women, and studies in the ED field regularly exclude men. Research efforts are needed to better understand the role of gender and sex in EDs. This review describes the role of gender and sex in the development of EDs from a biopsychosocial perspective.MethodsThe primary hypothesis of this narrative review is that gender and sex interact to influence ED risk. The literature review was conducted using the PubMed database.ResultsThis review first presents the general characteristics and prevalence of EDs according to gender and sex. Next, neurodevelopmental processes, neurobiology, gender roles, body image, and the minority stress model are addressed. Lastly, research perspectives to better include gender and sex in the field of EDs are discussed (e.g., representation of gender and sex diversities, development of appropriate assessment tools, and increasing awareness).ConclusionAlthough substantial knowledge gaps remain, there is a growing recognition of the importance of integrating gender and sex in ED research that holds promise for further development in the field.
Sustainable development‐oriented regulatory and competitive pressures to shift toward a circular economy: The role of environmental orientation and Industry 4.0 technologies
Authors: Al‐Swidi Abdullah Kaid , Hair Joseph F. , Al‐Hakimi Mohammed A. 
Published: February 2023

AbstractAutomakers' transition from a linear economy to a circular economy (CE) in response to sustainable development‐oriented regulatory and competitive pressures is a challenging process that requires innovative, practical technologies. However, Industry 4.0 (I4.0) technologies are an important part of the transition to CE for environmentally friendly companies. In this study, we examine whether regulatory pressure (RP) and competitive pressure (CP) toward sustainability motivate firms to implement I4.0 technologies for CE, along with the mediating effects of environmental orientation (EO). PLS‐SEM via SmartPLS software was used to analyze data from 230 managers in the automotive and auto component manufacturing industries in India. The findings of this study showed that RP and CP positively influence I4.0 adoption, which impacts CE capability. Furthermore, EO partially mediates the relationship between RP and CP with I4.0 technologies. As a practical implementation of this study, to transition to CE and contribute to sustainable development, managers need to deal effectively with RP and CP. Several implications for theory and practice are discussed at the end of the study.
Open strategy and dynamic capabilities: A framework for circular economy business models research
Authors: De Angelis Roberta , Morgan Robert , De Luca Luigi M. 
Published: February 2023

AbstractThe circular economy has attracted the interest of business leaders, policy makers and academics alike for its potential to contribute to a more resilient, prosperous and resource‐efficient economy. The transition towards a circular economy requires new business models that challenge the linear logic of value creation that is still endemic across most industries. In turn, the transition from linear to circular business models involves the rethinking of strategic decision‐making processes and the development of new organisational capabilities. This paper addresses these important strategic implications of the emergence and implementation of circular business models. Coupling business models with open strategy and dynamic capabilities, we develop a “three‐pronged” strategy framework that advances the emerging field of circular business model research. Our contribution is crystallised into a series of propositions and future research questions for scholars working at the intersection of the circular economy and the strategy literature.
Controlled Release of Doxorubicin from Magnetoliposomes Assisted by Low‐Frequency Magnetic Field
Authors: Maron Edyta , Krysinski Paweł , Chudy Michał 
Published: February 2023

AbstractThe article presents magnetoliposomes as potential carriers of doxorubicin. The magnetic properties of nanoparticles embedded in liposomes enable the targeting of drug‐loaded carriers to cancer cells and subsequent release of their payload using an external alternating magnetic field as a trigger. The cytotoxicity of empty and doxorubicin‐loaded magnetoliposomes in the absence and after exposure to magnetic field was evaluated in cancerous and normal breast cells. The characteristic shows the carrier with size distribution <130 nm, slightly negative zeta potential and polydispersity index <0.2. Doxorubicin was encapsulated in magnetoliposomes with an efficiency of 31 % and released in the presence of an alternating magnetic field at 50 %. Magnetoliposomes with drug provided high cytotoxic effect on tumor cells and low cytotoxic effect on normal cells. The research conducted in this article may indicate the potential application of the studied magnetoliposomes in release of drugs under the influence of magnetic field in cancer cells.
Clinical image report of a patient with cerebral schistosomiasis
Authors: Al‐Ameen Osamah , Faisal Mohanad , Yacout Khalid 
Published: February 2023

AbstractNeuro‐schistosomiasis is one of the most severe manifestations of Schistosoma infection. We report an MRI image of a patient who presented with a headache and was found to have a space‐occupying lesion on an MRI of the brain that was suggestive of neuro‐schistosomiasis and was successfully treated without invasive testing.
A case of Eagle syndrome with a marked elongation of the styloid process; investigating its relation to ankylotic spondylitis
Authors: Angelou Dimitrios , Hope Nicholas , Canning John , Stewart Rosemary 
Published: February 2023

AbstractEagle syndrome is characterized by the presence of an abnormally elongated styloid process and has been related to different etiologies, including enthesitis, a known feature of spondyloarthropathies. We are describing a case of marked elongation of the styloid process in a patient with pre‐existing ankylosing spondylitis and associated enthesopathy.