bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative Daycare as a Safe and Cost-Effective Option for Secondary Alveolar Bone Graft (SABG) Surgery: A Retrospective Comparative Cohort Study
Authors: Natsir Kalla Diandra S. , Ruslin Muhammad , Aartman Irene H. A. , Helder Marco N. , Forouzanfar Tymour , Gilijamse Marjolijn 
Published: April 2023

Objective To evaluate the outcomes of Secondary Alveolar Bone Grafting (SABG) in patients treated either in daycare or with multiple day hospitalization (MDH) in relation to costs and complication rates. Design Retrospective comparative cohort study. Setting The data was collected from two settings: Postoperative daycare or MDH after oral cleft surgery in an Academic Medical Center in The Netherlands. Patients Data of 137 patients with unilateral Cleft lip, alveolus, and palate (CLAP) treated between 2006-2018 were evaluated. Registered clinical variables: age, gender, cleft subtype, bone donor site, type of hospitalization, length of stay, additional surgery, complications, surgeons, and costs. Interventions Closure of the alveolar cleft with/without closure of the anterior palate. Main outcome measures Univariate analyses. Results Of the 137 patients, 46.7% were treated in MDH, and 53.3% in daycare. Total costs for daycare were significantly lower ( P < .001). All patients treated in daycare received mandibular symphysis bone, whereas in MDH, 46.9% received iliac crest bone instead. Bone donor site was associated with postoperative care type. Complication rates were slightly but not significantly higher in daycare (26%) vs. MDH (14.1%) ( P = .09). Most were Grade I (minor) according to Clavien Dindo classification. Conclusions Daycare after alveolar cleft surgery is about as safe as MDH, but significantly cheaper.
Serositis causing pericardial and pleural effusions after eight years of maintenance ibrutinib for Waldenstrom's macroglobulinemia
Authors: Johnson Grace , Baviriseaty Niharika , Massanet Nicholas , Kooper Jeffrey 
Published: April 2023

Introduction Ibrutinib is a tyrosine kinase inhibitor approved for multiple B-cell malignancies, including Waldenstrom's macroglobulinemia in 2014. Although the drug portends favorable outcomes, it also bears a profile of side effects. Current literature describes only two cases of nonhemorrhagic pericardial effusion associated with ibrutinib use, and here we present the third. This case recounts an episode of serositis causing pericardial and pleural effusions and diffuse edema after eight years of maintenance ibrutinib for Waldenstrom's macroglobulinemia (WM). Case report A 90-year-old male with WM and atrial fibrillation presented to the emergency department for a week of progressive periorbital and upper and lower extremity edema, dyspnea, and gross hematuria, despite increasing at-home diuretic dose. The patient was on 140 mg ibrutinib twice daily. Labs showed stable creatinine, serum IgMs of 97, and negative serum and urine protein electrophoresis. Imaging revealed bilateral pleural effusions and pericardial effusion with impending tamponade. All other workup was unrevealing, diuretics were ceased, pericardial effusion was monitored with serial echocardiograms, and ibrutinib was exchanged for low-dose prednisone. Management and outcome After five days, the effusions and edema dissipated, hematuria resolved, and patient was discharged. Resumption of lower dose ibrutinib one month later led to a subsequent return of edema, which again subsided with cessation. Reevaluation of maintenance therapy continues outpatient. Conclusion Patients on ibrutinib presenting with dyspnea and edema should be monitored for pericardial effusion; the drug should be held in exchange for anti-inflammatory therapy, and future management should involve cautious, low-dose resumption, or exchange for alternative therapy.
Outcomes After Concomitant Hip Arthroscopy and Periacetabular Osteotomy: A Systematic Review
Authors: Lee Michael S. , Fong Scott , Owens Jade S. , Mahatme Ronak J. , Kim David N. , Gillinov Stephen M. , Moran Jay , Simington Jacquelyn , Islam Wasif , Abu Seyi , Jimenez Andrew E. 
Published: April 2023

Background: Despite several studies’ reports on outcomes of concomitant hip arthroscopy and periacetabular osteotomy (PAO), there is a paucity of aggregate data in the literature. Purpose: To evaluate outcomes and survivorship after concomitant hip arthroscopy and PAO. Study Design: Systematic review; Level of evidence, 4. Methods: The PubMed, Cochrane, and Scopus databases were searched in April 2022 using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The following keywords were used: (hip OR femoroacetabular impingement) AND (arthroscopy OR arthroscopic) AND (periacetabular osteotomy or rotational osteotomy) AND (outcomes OR follow-up). Of 270 articles initially identified, 10 studies were ultimately included. The following information was recorded for each study if available: publication information; study design; study period; patient characteristics; follow-up time; indications for hip arthroscopy; patient-reported outcomes (PROs); rates of secondary hip preservation surgeries; and rates of conversion to total hip arthroplasty (THA). Survivorship was defined as nonconversion to THA. Results: The study periods for the 10 included articles ranged from 2001 to 2018. Three studies were level 3 evidence, and 7 studies were level 4 evidence. This review included 553 hips with a mean follow-up of 1 to 12.8 years. All 10 studies listed dysplasia as an indication for surgery. Of 9 studies that reported PRO scores, 7 reported significant improvement after surgery. Studies with a <5-year follow-up reported conversion to THA rates of 0% to 3.4% and overall secondary surgery rates of 0% to 10.3%. Similarly, studies with >5-year follow-up reported conversion to THA rates of 0% to 3% and overall secondary surgery rates of 0% to 10%. Conclusion: Patients who underwent concomitant hip arthroscopy and PAO reported favorable outcomes, with 7 of the 9 studies that provided PRO scores indicating significant preoperative to postoperative improvement.
Association of Infrapatellar Fat Pad Fibrosis at 3 Months After ACL Reconstruction With Short-term Clinical Outcomes and Inflammatory Cytokine Levels in the Synovial Fluid
Authors: Nakagawa Yusuke , Tsuji Kunikazu , Nakamura Tomomasa , Katagiri Hiroki , Ozeki Nobutake , Shioda Mikio , An Jae-Sung , Yoshida Ryu , Sekiya Ichiro , Koga Hideyuki 
Published: April 2023

Background: Infrapatellar fat pad (IFP) fibrosis is reportedly associated with anterior knee pain and the progression of patellofemoral osteoarthritis after anterior cruciate ligament reconstruction (ACLR). However, causes of IFP fibrosis after ACLR have not been sufficiently investigated. Purpose: To compare the descriptive characteristics, clinical outcomes, and inflammatory cytokine levels in the synovial fluid between patients who underwent ACLR with versus without severe IFP fibrosis. Study Design: Cohort study; Level of evidence, 3. Methods: Patients who underwent primary ACLR using autologous hamstring tendon were divided into 2 groups based on magnetic resonance imaging IFP fibrosis scoring (grades 0-5) at 3 months after surgery: the severe fibrosis group (grades 4 and 5) and mild fibrosis group (grades 0-3). Synovial fluid was aspirated on postoperative day 3 or 4 to measure inflammatory cytokine levels. Patient characteristics, clinical outcomes at 3 and 12 months after surgery, and inflammatory cytokine (interleukin [IL]-1β, IL-2, IL-6, IL-8, IL-10, tumor necrosis factor–α, and interferon-γ) levels were compared between the groups. Results: Of the 36 patients included, 7 were allocated to the severe fibrosis group and 29 were allocated to the mild fibrosis group. The severe fibrosis group had a significantly longer operation time (153.0 vs 116.5 minutes for mild fibrosis; P = .007). Compared with the mild fibrosis group, the severe fibrosis group had greater pain during stair climbing (2.0 vs 0.7; P = .01) and a lower extension muscle strength ratio (operated/healthy side, 52.9% vs 76.1%; P < .001) at 3 months, and the severe fibrosis group had a lower Lysholm score (93.7 vs 97.3; P = .026) and greater knee extension (0.3° vs 1.9°; P = .043) and flexion angle restriction (142.9° vs 149.0°; P = .013) at 12 months. The severe fibrosis group demonstrated higher IL-1β (2.6 vs 1.4 pg/mL; P = .022), IL-6 (2.0 vs 1.1 ng/mL; P = .029), and interferon-γ levels (11.3 vs 4.0 pg/mL; P = .044). Conclusion: Severe IFP fibrosis was associated with a longer operation time, higher inflammatory cytokine level in the synovial fluid, and worse clinical outcomes at 3 and 12 months after ACLR.
Lateral Meniscal Allograft Transplantation With Distal Femoral Osteotomy
Authors: Meeks Brett D. , Ulrich Marisa N. , Duerr Robert A. , Flanigan David C. 
Published: April 2023

Background: Meniscal allograft transplantation improves functional and patient-reported outcomes in patients with meniscal deficiency without significant osteoarthritis. In addition, it is known that valgus malalignment of the knee can lead to meniscal and chondral damage, and surgery is often indicated to restore the mechanical axis and slow progression of osteoarthritis. Indications: Indications for this procedure include patients with symptomatic lateral meniscal deficiency with associated valgus deformity of the knee. Patient’s age must be less than 50 years, body mass index less than 35 kg/m2, meniscal deficiency, and ipsilateral pain with or without swelling. Ligament tears, focal cartilage loss, and malalignment are not contraindications if also corrected. Technique Description: We begin by removing the remaining lateral meniscus, taking care to leave a small peripheral rim of meniscus. A transpatellar tendon arthrotomy is performed, and the meniscal allograft is passed through the arthrotomy and into the knee. An inside-out repair is performed using vertical mattress sutures. The sutures are tightened and tied with the knee at 30° to 40° of flexion. The distal femoral osteotomy is then performed. An approach is made to the lateral femur, where initial guidewires are placed using fluoroscopic guidance. The initial saw cut is made about 75% of the way across the femur, and an osteotome is used to complete the osteotomy. Care is taken to preserve the far medial cortex. An adjustable wedge osteotome is placed to open the lateral cortex in accordance with the preoperative template. The cortical wedge is fashioned using the tibial allograft from the meniscal transplant and is placed into the osteotomy. The osteotomy is secured using a locking plate with locking screws, and this is confirmed in safe position using fluoroscopy prior to the conclusion of the case. Results: Patients will have effective deformity correction and alleviation of pain. Many patients can return to sport without restrictions following appropriate rehabhilitation. Conclusion: Lateral meniscal allograft transplantation with distal femoral opening wedge osteotomy is an effective treatment for symptomatic lateral meniscal insufficiency with associated valgus deformity of the knee in patients without osteoarthritis. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Mesenchymal stem cells reversibly de-differentiate myofibroblasts to fibroblast-like cells by inhibiting the TGF-β-SMAD2/3 pathway
Authors: Xu Ruohao , Wu Miao , Wang Yawen , Li Chao , Zeng Lingji , Wang Yulian , Xiao Maozhi , Chen Xiaomei , Geng Suxia , Lai Peilong , Du Xin , Weng Jianyu 
Published: April 2023

AbstractBackgroundMyofibroblasts (MFB), one of the major effectors of pathologic fibrosis, mainly derived from the activation of fibroblast to myofibroblast transition (FMT). Although MFBs were historically considered terminally differentiated cells, their potential for de-differentiation was recently recognized and implied with therapeutic value in treating fibrotic diseases, for instance, idiopathic pulmonary fibrosis (IPF) and post allogeneic hematopoietic stem cell transplantation bronchiolitis obliterans (BO). During the past decade, several methods were reported to block or reverse MFB differentiation, among which mesenchymal stem cells (MSC) have demonstrated potential but undetermined therapeutic values. However, the MSC-mediated regulation of FMT and underlying mechanisms remained largely undefined.MethodBy identifying TGF-β1 hypertension as the pivotal landmark during the pro-fibrotic FMT, TGF-β1-induced MFB and MSC co-culture models were established and utilized to investigate regulations by MSC on FMT in vitro. Methods including RNA sequencing (RNA-seq), Western blot, qPCR and flow cytometry were used.ResultOur data revealed that TGF-β1 readily induced invasive signatures identified in fibrotic tissues and initiated MFB differentiation in normal FB. MSC reversibly de-differentiated MFB into a group of FB-like cells by selectively inhibiting the TGF-β-SMAD2/3 signaling. Importantly, these proliferation-boosted FB-like cells remained sensitive to TGF-β1 and could be re-induced into MFB.ConclusionOur findings highlighted the reversibility of MSC-mediated de-differentiation of MFB through TGF-β-SMAD2/3 signaling, which may explain MSC's inconsistent clinical efficacies in treating BO and other fibrotic diseases. These de-differentiated FB-like cells are still sensitive to TGF-β1 and may further deteriorate MFB phenotypes unless the pro-fibrotic microenvironment is corrected.
Experimental Study on the Reduction Effect of Pit Texture on Disassembly Damage for Interference Fit
Authors: Zhou Dan , Xu Yi , Gao Xin , Huang Haihong , Lv Songjiang 
Published: April 2023

AbstractAfter remanufacturing disassembly, several kinds of friction damages can be found on the mating surface of interference fit. These damages should be repaired and the cost is closely related to the severity of damages. Inspired by the excellent performance of surface texture in wear reduction, 5 shapes of pit array textures are added to the specimens’ surface to study their reduction effect of disassembly damage for interference fit. The results of disassembly experiments show that the order of influence of texture parameters on disassembly damage is as follows: equivalent circle diameter of single texture, texture shape and texture surface density. The influence of equivalent circle diameter of single texture and texture shape are obviously more significant than that of texture surface density. The circular texture with a surface density of 30% and a diameter of 100 μm shows an excellent disassembly damage reduction effect because of its perfect ability of abrasive particle collection. And the probability of disassembly damage formation and evolution is also relatively small on this kind of textured surface. Besides, the load-carrying capacity of interference fit with the excellent texture is confirmed by load-carrying capacity experiments. The results show that the load-carrying capacity of the excellent texture surface is increased about 40% compared with that of without texture. This research provides a potential approach to reduce disassembly damage for interference fit.
Design and Implementation of a Battery Big Data Platform Through Intelligent Connected Electric Vehicles
Authors: Xiong Rui , Zhu Baoqiang , Zhang Kui , Duan Yanzhou , Sun Fengchun 
Published: April 2023

AbstractThe development of a battery management algorithm is highly dependent on high-quality battery operation data, especially the data in extreme conditions such as low temperatures. The data in faults are also essential for failure and safety management research. This study developed a battery big data platform to realize vehicle operation, energy interaction and data management. First, we developed an electric vehicle with vehicle navigation and position detection and designed an environmental cabin that allows the vehicle to operate autonomously. Second, charging and heating systems based on wireless energy transfer were developed and equipped on the vehicle to investigate optimal charging and heating methods of the batteries in the vehicle. Third, the data transmission network was designed, a real-time monitoring interface was developed, and the self-developed battery management system was used to measure, collect, upload, and store battery operation data in real time. Finally, experimental validation was performed on the platform. Results demonstrate the efficiency and reliability of the platform. Battery state of charge estimation is used as an example to illustrate the availability of battery operation data.
Facile synthesis and characterization of Fe3O4/analcime nanocomposite for the efficient removal of Cu(II) and Cd(II) ions from aqueous media
Authors: Algethami Faisal K. , Al-Wasidi Asma S. , Al-Farraj Eida S. , Katouah Hanadi A. , Abdelrahman Ehab A. 
Published: April 2023

AbstractIn the water purification field, heavy metal pollution is a problem that causes severe risk aversion. This study aimed to examine the disposal of cadmium and copper ions from aqueous solutions by a novel Fe3O4/analcime nanocomposite. A field emission scanning electron microscope (FE-SEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction were used to characterize the synthesized products. The FE-SEM images showed that the analcime and Fe3O4 samples consist of polyhedral and quasi-spherical shapes with average diameters of 923.28 and 28.57 nm, respectively. Besides, the Fe3O4/analcime nanocomposite consists of polyhedral and quasi-spherical shapes with average diameters of 1100.00 nm. The greatest uptake capability of the Fe3O4/analcime nanocomposite toward the copper and cadmium ions is 176.68 and 203.67 mg/g, respectively. The pseudo-second-order kinetic model and Langmuir equilibrium isotherm best describe the uptake of copper and cadmium ions using the Fe3O4/analcime nanocomposite. The uptake of copper and cadmium ions using the Fe3O4/analcime nanocomposite is exothermic and chemical in nature.
Echinococcosis of the detrusor: report of the first pediatric case
Authors: Haif Assia , Achouri Djelloul , Merouani Mohamed Yacine , Ouhida Sorya 
Published: April 2023

Abstract
Background
The parasitic disease known as the cystic echinococcosis (CE) is brought on by cysts made up of the larval forms (metacestodes) of Echinococcus tapeworms. In North Africa, it is greater in rural regions. This is unusual for a primary supravesical position.

Case presentation
We report a case of a 6-year-old boy who had a palpable abdominal mass with hypogastric abdominal pain.
A pelvic ultrasound examination demonstrated a voluminous intra-abdominal supravesical cystic formation with clear limits and regular contours of heterogeneous anechogenic echostructure and the presence of multiple hyperechoic septa separating the cubicles (daughter vesicles) in a honeycomb pattern. Computed tomography confirmed a cystic echinococcosis stage III of the pelvis.
After a laparotomy surgery with total cystectomy, the patient was discharged with prescribed albendazole 10 mg/kg/day. Cystic echinococcosis was established by histological analysis.
The aim is to demonstrate that from a literature search, we think this is the first case of cystic echinococcosis of the detrusor in children.

Conclusion
Primary pelvic cystic echinococcosis is uncommon and even less common among children. Cystic echinococcosis must be taken into account in the differential diagnosis when there is an abdominal mass, particularly in locations where it is prevalent.
Identification of mitophagy-related biomarkers and immune infiltration in major depressive disorder
Authors: Zhang Jing , Xie Shujun , Xiao Rong , Yang Dongrong , Zhan Zhi , Li Yan 
Published: April 2023

Abstract
Background
Major depressive disorder (MDD) is a life-threatening and debilitating mental health condition. Mitophagy, a form of selective autophagy that eliminates dysfunctional mitochondria, is associated with depression. However, studies on the relationship between mitophagy-related genes (MRGs) and MDD are scarce. This study aimed to identify potential mitophagy-related biomarkers for MDD and characterize the underlying molecular mechanisms.

Methods
The gene expression profiles of 144 MDD samples and 72 normal controls were retrieved from the Gene Expression Omnibus database, and the MRGs were extracted from the GeneCards database. Consensus clustering was used to determine MDD clusters. Immune cell infiltration was evaluated using CIBERSORT. Functional enrichment analyses were performed to determine the biological significance of mitophagy-related differentially expressed genes (MR-DEGs). Weighted gene co-expression network analysis, along with a network of protein–protein interactions (PPI), was used to identify key modules and hub genes. Based on the least absolute shrinkage and selection operator analysis and univariate Cox regression analysis, a diagnostic model was constructed and evaluated using receiver operating characteristic curves and validated with training data and external validation data. We reclassified MDD into two molecular subtypes according to biomarkers and evaluated their expression levels.

Results
In total, 315 MDD-related MR-DEGs were identified. Functional enrichment analyses revealed that MR-DEGs were mainly enriched in mitophagy-related biological processes and multiple neurodegenerative disease pathways. Two distinct clusters with diverse immune infiltration characteristics were identified in the 144 MDD samples. MATR3, ACTL6A, FUS, BIRC2, and RIPK1 have been identified as potential biomarkers of MDD. All biomarkers showed varying degrees of correlation with immune cells. In addition, two molecular subtypes with distinct mitophagy gene signatures were identified.

Conclusions
We identified a novel five-MRG gene signature that has excellent diagnostic performance and identified an association between MRGs and the immune microenvironment in MDD.
Three-dimensional pelvic ultrasound is a practical tool for the assessment of anal fistula
Authors: Ren Junyi , Bai Wenkun , Gu Liangrui , Li Xiao , Peng Xue , Li WeiMei 
Published: April 2023

Abstract
Objective
This study aims to investigate the diagnostic value of three-dimensional pelvic ultrasound in the preoperative assessment of anal fistula compared with findings of MRI and surgery.

Methods
A total of 67 patients (62 males) with suspected anal fistula were analyzed retrospectively. Preoperative three-dimensional pelvic ultrasound and magnetic resonance imaging were performed in all patients. The number of internal openings and the type of fistula were recorded. The accuracy of three-dimensional pelvic ultrasound was determined by comparing these parameters with surgical outcomes.

Results
At surgery, 5 (6%) were extrasphincteric, 10 (12%) were suprasphincteric, 11 (14%) were intersphincteric, and 55 (68%) were transsphincteric. There was no significant difference in the accuracy of pelvic 3D US and MRI, based on internal openings (97.92%, 94.79%), anal fistulas (97.01%, 94.03%), and those under Parks classification (97.53%, 93.83%).

Conclusion
Three-dimensional pelvic ultrasound is a reproducible and accurate method for determining the type of fistula and detecting internal openings and anal fistulas.