bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equine neutrophils selectively release neutrophil extracellular traps in response to chemical and bacterial agonists
Authors: Sheahan Breanna J. , Schubert Alicia G. , Schubert William , Sheats M. Katie , Schnabel Lauren V. , Gilbertie Jessica M. 
Published: February 2025

IntroductionNeutrophil extracellular traps (NETs) play a significant role in response to a variety of infectious and inflammatory stimuli in human and veterinary medicine. Although entrapment of bacteria can be an important function of NETs, the exuberant release of DNA and other intracellular molecules has also been negatively implicated in the pathogenesis of different diseases. Thus, NET formation must be tightly controlled and represents an opportunity for therapeutic interventions. Horses are particularly sensitive to bacterial stimuli that have previously been shown to cause NETs in other species, but the species-specific processes that control NET release have not been fully elucidated.MethodsThe purpose of this study was to compare the magnitude of response of equine neutrophils to different chemical and bacterial stimuli, including phorbol 12-myristate 13-acetate (PMA), a calcium ionophore (A23187), Staphylococcus aureus, and Escherichia coli. In addition, we investigated whether ex vivo equine NET formation is controlled by the NADPH-oxidase (NOX) pathway and by autophagy, both of which control NET formation in other species.ResultsWe demonstrated that equine neutrophils produce robust NETs in response to calcium ionophore and E. coli stimuli and produce fewer NETs in response to PMA and S. aureus. Both NOX-dependent and NOX-independent pathways of NET formation were identified in equine neutrophils. Autophagy inhibition altered the mechanics of NET release, by reducing the amount of extracellular DNA stranding.DiscussionThese results provide insight into equine-specific neutrophil biology, which could be key for managing equine diseases such as asthma and laminitis.
Vaccination versus antimicrobials to prevent Porcine Proliferative Enteropathy: associated costs and effects on piglets’ growth, health, and serological performance
Authors: Gallina Marco Aurélio , Quirino Monike Willemin , Frandoloso Rafael , Tutida Yuso Henrique , Norenberg Adriano , Coldebella Arlei , Bianchi Ivan , Kich Jalusa Deon 
Published: February 2025

IntroductionThis study evaluated vaccination and prophylactic use of antimicrobials as strategies to prevent Porcine Proliferative Enteropathy (PPE) during nursery and growth-finishing phases.MethodsThree hundred weaned piglets (~ 29 days old) were distributed into groups: NVMED – no vaccinated against Lawsonia intracellularis but in-feed medicated with antimicrobials (amoxicillin, florfenicol, lincomycin, spectinomycin and tilmicosin); VMED – vaccinated and in-feed medicated; VNMED – vaccinated but no in-feed medicated. Piglets were vaccinated at weaning (Porcilis® Ileitis, MSD Animal Health). The following variables were assessed: growth and health performance, anti-L. intracellularis IgG levels, L. intracellularis fecal shedding, Pneumonia and Pleurisy Index (PPI) at slaughter, antimicrobial consumption and costs, and vaccination expenses.ResultsAverage daily gain (ADG) at the nursery phase was lower in VNMED group (p &lt; 0.01); however, there was no treatment effect on feed conversion, ADG, and body weight at growth-finishing phase (p ≥ 0.23). Similar anti-L. intracellularis IgG levels were found for VMED and VNMED groups at all evaluated moments (p = 0.01). L. intracellularis was only detected in feces samples from 4/90 tested piglets and no difference in health performance was found (p &gt; 0.05). Groups presented PPI &lt; 0.89. In-feed antimicrobial consumption and related costs were 3 to 3.5-fold higher for NVMED and VMED groups compared to VNMED group.DiscussionThe prophylactic administration of antimicrobials used in this study did not affect the serological performance post-vaccination against L. intracellularis. Additionally, vaccine use to prevent PPE reduced the antimicrobial consumption and related costs by ~70%, with no impairments on production outputs.
The Implementation of Geospatial Analysis on Hotel Occupancy Rate
Authors: Nazuli Muhammad Fachry , Panuntun Satria Bagus , Maulana Addin , Takdir  , Pramana Setia 
Published: February 2025

Introduction/Main Objectives: One of the main attributes of hotel selection and customer satisfaction is its location. Background Problems: Strategic location leads to higher demand for accommodation. Accommodation demand is reflected in hotel occupancy levels, which indicate the percentage of reserved rooms at a specific period. Novelty: This study aims to investigate the effect of spatial location on hotel occupancy rates by analyzing data collected in online hotel reservation applications. A study related to the effects of location and hotel occupancy has never been conducted in Indonesia. Research Methods: We use data from hotels located in the province of Yogyakarta, which contains 245 hotels spread over three regencies/cities, namely Yogyakarta City, Sleman Regency, and Bantul Regency. We conducted a spatial regression analysis, namely the Spatial Error Model (SEM), with a spatial weight matrix using a radius of 3.2 km. Finding/Results: We found that spatial locations affect the occupancy rates of hotels based on the online hotel reservation application that we observed. These spatial locations include the distance from the hotel to the airport, the distance from the hotel to the bus stop, and the number of nearby restaurants, offices, and hotels.
PERAN GURU DALAM MENINGKATKAN KUALITAS BACA AL-QUR`AN SANTRI PUTRI KELAS AWALIYAH “A”
Authors: Qomari Nur 
Published: February 2025

Tujuan penelitian ini adalah untuk mengetahui peran guru dalam meningkatkan kualitas baca Al-Qur`an Majlis Tarbiyatul Qur`an PP. Miftahul Ulum Atthohirin Gondanglegi kulon kecamatan Gondanglegi kabupaten Malang. dan untuk mengetahui dampak dari peran Guru pada Santri PP Miftahul Ulum Atthohirin. Jenis penelitian ini adalah penelitian lapangan (Field Research),dan menggunakan pendekatan deskriptif kualitatif. Teknik pengumpulan data dilakukan dengan wawancara (Interview), obserfasi partisipan dan dokumentasi. Uji keabsahan data dengan cara Triagulasi sumber data, yaitu dengan menggunakan berbagai sumber untuk mendapatkan informasi, Triagulasi metode, yaitu dengan membandingkan berbagai data hasil interview,observasi,dan dokumentasi. Data di analisis dengan langkah – langkah yang terdiri dari data reduction (Reduksi data), Data dispay (penyajian data) dan verification (penarikan kesimpulan). Hasil penelitian ini menunjukkan bahwa peran guru dalam meningkatka kualitas Membaca Al-Qur`an sangat di butuhkan untuk membangun santri agar bisa membaca Al-Qur`an lebih baik, karena guru menjadi ujung tombak pelaksanaan pendidikan Al-Qur`an untuk bisa mencetak santri yang pandai dalam membaca Al-Qur`an.
Pembentukan Karakter Generasi Muda Yang Berakhlak Islami ala Manajemen Pendidikan Pesantren
Authors: Annisya Susanti Mutiara , Gery Resty Galuh 
Published: February 2025

ABSTRAK: Pembentukan karakter pada generasi muda merupakan hal yang sangat penting bagi kebangkitan umat Islam. Generasi muda adalah ujung tombak dan pilar utama bagi kebangkitan umat di masa depan. Generasi muda haruslah dibina dengan akhlak yang mulia agar dapat menjadi penyokong dan penyampaian risalah Islam. Pesantren, sebagai lembaga pendidikan Islam khas Indonesia yang dimana pesantren memiliki peran yang strategis dalam pembentukan karakter generasi muda Islami. Pesantren tidak hanya mengajarkan ilmu agama, akan tetapi juga menanamkan nilai-nilai moral dan spiritual kepada para santrinya. Terdapat manajemen pendidikan khas pesantren yang dapat diaplikasikan kepada para generasi muda, yakni; 1) Pengarahan 2) Pelatihan 3) Penugasan 4) Pembiasaan 5) Pengawalan 6) Uswah Hasanah. Terdapat enam pokok utama manajemen khas pesantren yang dapat dijadikan sebagai bentuk Upaya dalam penbentukan karakter pada generasi muda Islami agar dapat menjadi lebih terarah dan totalitas. Pada penelitian kali ini penulis menggunakan metode Kualitatif dengan pendekatan yang digunakan adalah analisis dekskriptif yaitu, menceritakan kembali apa yang sudah dilihat dan diteliti oleh peneliti. Sehingga diperoleh hasil bahwa dengan penanaman sistem manajemen pendidikan pesantren yang ada pada pesantren menghasilkan kebiasaan positif yang berkelanjutan pada diri santri sehingga mampu menghadirkkan Long Life Education pada pribadi santri meskipun sudah tidak menetap di lingkungan pesantren.
Systematic Literature Review for the Effect of the Use of Live Stream Feature on Purchase Intention
Authors: Amalina Nabila Nur Fitri 
Published: February 2025

Live streaming has become one of the most effective digital marketing tools in encouraging consumer purchase intention, both on social media platforms and e-commerce. This study uses the Systematic Literature Review (SLR) method to identify and analyze the factors that affect the success of the live streaming feature in increasing consumer purchase intention. Based on an analysis of 15 selected journals, it was found that elements such as interactivity, product visualization, entertainment elements, streamer credibility, and information quality played a significant role in building consumer trust, reducing uncertainty, and creating a positive shopping experience. Differences in effectiveness were also found between social media platforms and e-commerce. Social media is more effective at building brand awareness and audience engagement through entertaining content, while e-commerce excels at driving direct transactions due to its integrated payment features and real-time promotions. The study concludes that the success of live streaming is highly dependent on the characteristics of the platform, the type of product, and the content delivery strategy that is relevant to consumer preferences. Strategic advice is given to maximize the potential of live streaming as an adaptive and effective marketing tool in the digital ecosystem.
Analisis Pertanggungjawaban Hukum Tukang Gigi dan Perlindungan terhadap Konsumen Jasa Tukang Gigi di Indonesia
Authors: Sedyaningtyas Sekar , Lubis Arief Fahmi , Rokhmat Rokhmat 
Published: February 2025

The work of dentists has been regulated in the Regulation of the Minister of Health Number 39 of 2014 concerning Coaching, Supervision and Licensing, Dentist Work. The authority of the dentist only makes and installs removable dentures, either partially or fully, using heat curing acrylic material and meets the health element where it does not cover the remaining tooth roots. Although the standard of work and authority of dentists has been regulated, many dentists ignore it by doing work outside of their authority and often do not meet medical rules in practice. This can certainly cause losses for consumers, both material and immaterial losses. There must be a balance between the accountability carried out by dentists and legal protection for consumers of dentist services who feel disadvantaged so that consumers are not always in a weak position. The research conducted is normative juridical and carried out with several approaches such as legislation, conceptual and case study approaches. Primary, secondary and tertiary data are used to answer the problems of this study. The results of this study show that the accountability of dentists can be carried out in the form of administrative law, civil law and criminal law. Consumer protection has been regulated in Law Number 8 of 1999. Dentist consumer protection is carried out by providing compensation. In addition, it can also be done by holding coaching and supervision carried out by the government.
Impact of sleep-related habits on the 5-year survival rate in elderly and long-living individuals
Authors: Vorobyeva N. M. , Isaev R. I. , Marakhovskaya E. A. , Malaya I. P. , Kotovskaya Yu. V. , Tkacheva O. N. 
Published: February 2025

BACKGROUND. Healthy, good quality sleep is one of the necessary conditions for achieving longevity and enhancing survival. Numerous general population studies revealed a relationship between some sleep-related habits and mortality, but the results of similar studies conducted in older participants are not so unambiguous.AIM. To study the impact of sleep-related habits on the 5-year survival rate in participants aged ≥75 years.MATERIALS AND METHODS. The study included 223 participants (24% men) aged 75–98 years (median age: 87 years) who lived in Moscow and the Moscow region and were receiving routine inpatient care at the Russian Gerontology Clinical Research Center in 2011–2013. At admission, patients were surveyed using a specially developed questionnaire in order to assess social and behavioral factors such as lifestyle, habits, diet, and physical activity. The questionnaire included the following sleep-related items: 1) bedtime; 2) wake-up time; 3) nighttime sleep duration; 4) daytime napping. After discharge, patients were under follow-up for 5 years. Cases of all-cause mortality were registered.RESULTS. During 5 years of follow-up (median: 3.63 years), 88 (39.5%) people died. Accordingly, the 5-year survival rate was 60.5%, and the mean survival time was 4.44 [95% confidence interval (CI) 4.19–4.71] years. The study demonstrated that the most of the participants went to bed at 10–12 p.m. (65%), woke up at 6–8 a.m. (58%) and had a daytime napping (61%), and 68% of the participants had the duration of nighttime sleep within 7–9 h. Univariate regression analysis showed that late (after midnight) bedtime, waking up after 8 a.m., and long (≥10 h) nighttime sleep were associated with a 1.7–2.1-fold increase in the risk of death over the next 5 years. On the contrary, early (before midnight) bedtime, waking up between 4–8 a.m., and nighttime sleep for 5–9 h were associated with a 43–52% decrease in the risk of death over this period. Daytime napping had no effect on the 5-year survival rate. Multivariate regression analysis demonstrated that age (hazard ratio [HR] 1.09; 95% CI 1.02–1.17; p = 0.019), early (before midnight) bedtime (HR 0.55; 95% CI 0.31–0.97; p = 0.040) and 5–9 h nighttime sleep duration (HR 0,44; 95% CI 0.26–0.76; p=0.003) were independent predictors of the 5-year survival rate.CONCLUSION. In participants aged ≥75 years, who lived in Moscow and the Moscow region, early (before midnight) bedtime and medium (5–9 h) nighttime sleep duration are independent predictors for the 5-year survival rate and are associated with 45% and 56% reduction in the mortality risk, respectively, suggesting that a proper sleep may be a geroprotective factor.
Evolution of X-Ray Gas in SN 1987A from 2007 to 2021: Ring Fading and Ejecta Brightening Unveiled through Differential Emission Measure Analysis
Authors: Sun Lei , Orlando Salvatore , Greco Emanuele , Miceli Marco , Chen Yang , Vink Jacco , Zhou Ping 
Published: February 2025

Abstract
As the nearest supernova (SN) observed since Kepler’s SN of 1604, SN 1987A provides an unprecedented opportunity to study in detail the early evolution of supernova remnants. Despite extensive studies through both observations and simulations, there is still an urgent need for a more effective approach to integrate the results from two sides. In this study, we conducted a detailed differential emission measure (DEM) analysis on the XMM-Newton observations taken in 2007 to 2021 to characterize the continuous temperature structure of SN 1987A, which can be better compared with simulations. The X-ray plasma exhibits a temperature distribution with a major peak at ∼0.5–1 keV and a high-temperature tail extending to ≳5 keV. The emission measure (EM) of the major peak started to decline around 2014, while the EM of the tail continued increasing and appears to have formed a secondary peak at ∼3–5 keV in recent years. Our DEM results are consistent with simulations, which help to further identify the major peak as originating from the equatorial ring and the secondary peak as arising from the newly shocked ejecta. Together with the simulations, our DEM analysis reveals recent fading of the ring and brightening of the ejecta in X-rays from SN 1987A. Additionally, we observed a recent decrease in the centroid energy of the Fe K line, providing further evidence of newly shocked ejecta.
A Survey of General Relativistic Magnetohydrodynamic Models for Black Hole Accretion Systems
Authors: Dhruv Vedant , Prather Ben , Wong George N. , Gammie Charles F. 
Published: February 2025

Abstract
General relativistic magnetohydrodynamics (GRMHD) simulations are an indispensable tool in studying accretion onto compact objects. The Event Horizon Telescope (EHT) frequently uses libraries of ideal GRMHD simulations to interpret polarimetric, event-horizon-scale observations of supermassive black holes at the centers of galaxies. In this work, we present a library of 10 nonradiative, ideal GRMHD simulations that were utilized by the EHT Collaboration in their analysis of Sagittarius A*. The parameter survey explores both low (SANE) and high (MAD) magnetization states across five black hole spins a
* = −15/16, −1/2, 0, +1/2, +15/16 where each simulation was run out to 30,000 GM/c
−3. We find the angular momentum and energy flux in SANE simulations closely matches the thin-disk value, with minor deviations in prograde models due to fluid forces. This leads to spin equilibrium around a
* ∼ 0.94, consistent with previous studies. We study the flow of conserved quantities in our simulations and find mass, angular momentum, and energy transport in SANE accretion flows to be primarily inward and fluid dominated. MAD models produce powerful jets with outflow efficiency >1 for a
* = + 0.94, leading to black hole spin-down in prograde cases. We observe outward directed energy and angular momentum fluxes on the horizon, as expected for the Blandford–Znajek mechanism. MAD accretion flows are sub-Keplerian and exhibit greater variability than their SANE counterpart. They are also hotter than SANE disks within r ≲ 10 GM/c
−2. This study is accompanied by a public release of simulation data at http://thz.astro.illinois.edu/.
Testing for Intrinsic Type Ia Supernova Luminosity Evolution at z > 2 with JWST
Authors: Pierel J. D. R. , Coulter D. A. , Siebert M. R. , Akins H. B. , Engesser M. , Fox O. D. , Franco M. , Rest A. , Agrawal A. , Ajay Y. , Allen N. , Casey C. M. , DeCoursey C. , Drakos N. E. , Egami E. , Faisst A. L. , Gezari S. , Gozaliasl G. , Ilbert O. , Jones D. O. , Karmen M. , Kartaltepe J. S. , Koekemoer A. M. , Lane Z. G. , Larson R. L. , Li T. , Liu D. , Moriya T. J. , McCracken H. J. , Paquereau L. , Quimby R. M. , Rich R. M. , Rhodes J. , Robertson B. E. , Sanders D. B. , Shahbandeh M. , Shuntov M. , Silverman J. D. , Strolger L. G. , Toft S. , Zenati Y. 
Published: February 2025

Abstract
The James Webb Space Telescope (JWST) is opening new frontiers of transient discovery and follow-up at high redshift. Here we present the discovery of a spectroscopically confirmed Type Ia supernova (SN Ia; SN 2023aeax) at z = 2.15 with JWST, including a NIRCam multiband light curve. SN 2023aeax lands at the edge of traditional low-z cosmology cuts because of its blue color (peak rest-frame B − V ∼ −0.3) but with a normal decline rate (Δm
15(B) ∼ 1.25), and applying a fiducial standardization with the BayeSN model we find the SN 2023aeax luminosity distance is in ∼0.1σ agreement with ΛCDM. SN 2023aeax is only the second spectroscopically confirmed SN Ia in the dark matter–dominated Universe at z > 2 (the other is SN 2023adsy), giving it rare leverage to constrain any potential evolution in SN Ia standardized luminosities. Similar to SN 2023adsy (B − V ∼ 0.8), SN 2023aeax has a fairly extreme (but opposite) color, which may be due to the small sample size or a secondary factor, such as host galaxy properties. Nevertheless, the SN 2023aeax spectrum is well represented by normal low-z SN Ia spectra, and we find no definitive evolution in SN Ia standardization with redshift. Still, the first two spectroscopically confirmed z > 2 SNe Ia have peculiar colors and combine for a ∼1σ distance slope relative to ΛCDM, though in agreement with recent SN Ia cosmological measurements.
La circulation générique d’une histoire : L’Oiseau bleu entre conte, lai et nouvelle
Authors: Mounier Pascale 
Published: February 2025

L’étude des antécédents de L’Oiseau bleu, récit phare des Contes des Fées de Madame d’Aulnoy paru en 1697, montre que le récit merveilleux divertissant de type galant qui voit le jour à la fin du xviie siècle s’approprie et infléchit des récits configurés dans des contextes de production et de réception variés. Un parcours régressif conduisant du conte merveilleux classique au lai médiéval en passant par la nouvelle est susceptible de servir un questionnement méthodologique sur le rôle de la typologie des récits dans leur interprétation. D’un point de vue thématique, les différentes manifestations du type AT 432 « The Prince as Bird », trop souvent occultées par L’Oiseau bleu, demandent d’abord à être identifiées ; elles ont été produites sous forme orale ou écrite entre le xiie et le xviie siècle en France et en Italie. D’un point de vue narratologique, le contexte d’accueil offert par l’œuvre enchâssante, la quantité et le développement des épisodes et le traitement du registre merveilleux élaborent ensuite des visions différentes du rôle des capacités individuelles et des forces incontrôlables. D’un point de vue socioculturel, des transferts idéologiques manifestent enfin des conceptions variées de l’amour passion et du rôle social du couple. Chacune des six adaptations littéraires retrouvées propose ainsi selon le sous-genre qui est le sien − lai, novella aventureuse à sujet féerique, fabia ou conte de salon − une compréhension spécifique du substrat mythique de l’histoire.
Annexe I. Profession : conteur
Authors: Paillier Roxane 
Published: February 2025

À partir de rencontres avec différents professionnels qui ont eu lieu en 2015 dans la région Ile-de-France (Évelyne Cevin, des bibliothécaires ayant reçu ou non une formation de conteur, des enseignants et le conteur professionnel Philippe Berthelot), nous observons quelles sont les éventuelles évolutions concernant l’usage du conte et ses pratiques en bibliothèque, en médiathèque, dans les écoles et dans les CDI (Centre de Documentation et d’Information).
Écrire, réécrire, mettre en dialogue des contes : l’exploration des portées éducatives du conte par Louise d’Épinay
Authors: Chiron Jeanne 
Published: February 2025

Dans la seconde moitié du xviiie siècle, le conte littéraire a déjà une histoire de plus d’un siècle derrière lui. Pourtant, c’est à cette époque que son usage éducatif se met clairement en place, dans le souci de répondre à de nombreuses critiques, notamment celles de ce merveilleux qui ne serait pas compatible avec une éducation aux lumières de la raison. Le conte emprunte alors les voies de la simplification et de la moralisation, sous l’influence des conteuses pédagogues que sont Leprince de Beaumont et Genlis. À cette même époque, une voix moins connue mérite une attention particulière : Louise d’Épinay, écrivaine philosophe, propose une utilisation pédagogique des contes fort instructive. Dans un texte entièrement dialogué, Les Conversations d’Émilie, une mère soumet à sa fille des contes qui sont l’objet de discussions et de critiques. Elle part d’une suspicion à leur égard, nous présentant ainsi un témoignage de la réception des contes à cette époque, mais choisit de les utiliser tout de même, pour répondre au désir de la jeune Émilie. À cette fin, elle écrit plusieurs versions de deux types de contes, un conte moral et un conte merveilleux, afin de les exploiter au mieux pour servir à l’éducation intellectuelle de l’enfant : dans ces opérations de réécriture apparaissent les conditions d’utilisation de cette fiction suspecte. Le conte pourra alors servir d’exercice de lecture critique, en manipulant tous les ingrédients, langagiers, narratifs et imaginaires du conte de fées.