bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bladder compliance dynamics of pelvic organ prolapse patients subjected to robotic-assisted sacrocolpopexy
Authors: Lau Hui-Hsuan , Su Tsung-Hsien , Lee Jie-Jen , Chou Dylan , Hsieh Ming-Chun , Lai Cheng-Yuan , Peng Hsien-Yu , Lin Tzer-Bin 
Published: July 2023

Abstract
Purpose Though a static compliance over the entire filling phase of the bladder can be easily assayed from the cystometry, a protocol measuring the dynamic compliance at a specific filling stage has not been established in human subjects/patients. As objective benefits of robotic-assisted sacrocolpopexy (RSCP) to the bladder function, particularly urine storage, of pelvic organ prolapse (POP) patients wait to be established, this study investigated the impact of RSCP on the bladder storage by focusing on its impact on compliance using the pressure-volume analysis (PVA), a protocol used to measure compliance dynamics in animals.
Materials and Methods: Pre- and post-operative PVAs derived from urodynamic studies of a total of 27 female POP patients, who underwent RSCP for prolapse stage ≥ II (POP Quantification system) were retrospectively reviewed. Bladder compliance, infused volume, and threshold pressure were analyzed.
Results: Compared with the pre-operative control, RSCP increased the mean compliance of the filling phase (p<0.01, N=27). Notably, RSCP increased the compliance of the late half (p<0.01, N=27) but displayed a negligible effect on that of the early half (p>0.05, N=27) of the filling phase. Mechanistically, RSCP decreased the change of detrusor pressure (p<0.01, N=27) without significantly affecting that of infused volume (p>0.05, N=27). Furthermore, RSCP decreased the ΔPdet in the late half (p<0.05, N=27) but not that in the early half (p>0.05, N=27) of the filling phase.
Conclusions: RSCP improved bladder storage as it increased bladder compliance, particularly the late filling phase; possibly by restoring anatomical location and geometric conformation for bladder expansion.
The improved outcome of reversal surgery for split stoma with peristomal incision compared to end stoma closure with middle incision in patients with Crohn’s disease
Authors: Wang Shixian , Du Kangling , Duan Ming , Xu Yihan , Guo Zhen , Gong Jianfeng , Zhu Weiming , Li Yi 
Published: July 2023

Abstract
Background
Temporary stoma formation is common in Crohn’s disease (CD), while stoma reversal is associated with postoperative morbidity. This study aimed at evaluating postoperative outcomes of split stoma reversal (SSR) with peristomal incision versus end stoma closure (ESC) with middle incision.
Methods
Consecutive patients with CD who underwent stoma reversal surgery between 2017 and 2021 were included. Patients’ demography, clinical characteristics, and postoperative outcomes were collected. Date analysis was performed to evaluate the short and long-term outcomes of reversal surgery.
Results
There were 255 patients who underwent stoma reversal surgeries meeting the inclusion criteria. Split stoma reversal was superior to end stoma closure in operative time, intraoperative blood-loss, incision length and classification, the length of postoperative hospital stay, hospital expense, and postoperative complications (P < 0.05). Additionally, patients in split stoma reversal showed significant decreased postoperative inflammatory parameters including white blood cell, procalcitonin, and percentage of neutrophils (P < 0.05). Interestingly, decreased postoperative surgical recurrence was found in patients with split stoma reversal compared to those with end stoma closure (8.3% vs 3.2%).
Conclusions
In case of stoma construction is indicated in patients with Crohn’s disease undergoing surgical resection, the split stoma is recommended, given that split stoma reversal with peristomal incision is associated with cosmetic outcome, short length of postoperative hospital stay as well as decreased postoperative morbidity.
Patient-specific estimation of trapeziometacarpal joint passive stiffness reveals a potential effect of hypermobility on osteoarthritis development
Authors: Valerio Thomas , Milan Jean-Louis , de Monsabert Benjamin Goislard , Vigouroux Laurent 
Published: July 2023

Abstract
Even if osteoarthritis is multifactorial, hypermobility of the trapeziometacarpal joint is commonly considered as one of the potential risk factors since it could affect the joint mechanical loadings. Nevertheless, the results are still controversial by the lack of quantitative validation. The objective of this study was to evaluate the effect of joint laxity on trapeziometacarpal cartilage mechanical loadings.
A patient-specific finite element model of the trapeziometacarpal joint passive stiffness was developed using segmentation from medical images. The joint passive stiffness was modeled by linear springs placed all around the joint. The linear spring stiffness was determined by using an optimization process to fit force-displacement data measured during laxity tests performed on eight healthy volunteers. The estimated passive stiffness parameters were then included in a full thumb finite element simulation of a pinch grip task driven by muscle forces to evaluate the effect on trapeziometacarpal loading. Correlation between the passive stiffness and the trapezium cartilage mechanical loadings in terms of joint contact pressures and maximum shear strain was analyzed.
A significant negative correlation was found between the trapeziometacarpal joint passive stiffness and the trapezium cartilage contact pressure during the pinch grip task simulated.
These results thus suggest that hypermobility of trapeziometacarpal joint could impact the trapezium cartilage contact pressure. Given that the risk of osteoarthritis development is associated with the intensity of cartilage loadings, our study argues in favor of the idea of an amplified risk with hypermobility.
A fine tune hyper parameter Gradient Boosting model for CPU utilization prediction in cloud environment
Authors: savita savita Khurana , gaurav Gaurav Sharma , Bhawna Bhawna Sharma 
Published: July 2023

AbstractCPU utilization prediction is key factor for efficient resource management and capacity planning in cloud computing environments. By accurately predicting utilization patterns, resource managers can dynamically distribute workloads to ensure optimal utilization of resources. The load can be equally distributed among virtual machines, leading to a reduction in VM migration and overhead time. This optimization significantly improves the overall performance of the cloud. This proactive approach enables efficient resource usage, minimizing the risk of bottlenecks and maximizing overall system performance. In this paper a Gradient Boosting model with hyper parameter tuning based upon grid search (GBHT) is proposed to enhance CPU utilization prediction. Multiple weak learners are combined in the proposed model to produce a powerful prediction model. and hyperparameters tuning is used to enhance its performance as well as predictive accuracy. Different machine learning and deep learning models are examined side by side. The results clearly demonstrate that the proposed GBHT model significantly contribute superior performance then the traditional machine learning models (SVM, KNN, Random Forest, Gradient Boost), deep learning models (LSTM, RNN, CNN), time series model (Facebook Prophet) and as well as the hybrid models, combining LSTM with Gradient Boost and Gradient Boost with SVM. The proposed model demonstrates superior performance compared to the other models, achieving the lowest MAPE of 0.01% and high accuracy with an R2 score of 1.00.
Balancing Cleaner Energy and Geopolitical Interests in the complex transition of the European Electricity Mix - From Fukushima to the Ukraine War
Authors: Cataldi Marcio , Espinosa Nieves , Jerez Sonia , Montávez Juan , Silveira Larissa da , Dupont Jairton , Teixeira Marcos 
Published: July 2023

Abstract
In the modern world, electric energy plays a pivotal role in sustaining life and driving technological, scientific, and human development. Consequently, the selection and availability of the energy sources used for electricity generation have become crucial elements of strategic planning for countries and economic blocks. Moreover, the impact of these choices extends beyond the mere energy demand/supply, affecting economies, societies and the environment across geographical boundaries. This study delves into the various factors influencing the composition and the recent expansion of the European electricity mix. It explores the interplay of environmental, climatic, political, economic, and external factors that shape Europe´s energy choices. To conduct this analysis, we utilized data from the International Energy Agency on electricity generation and GHG emissions. Data mining techniques were employed to uncover patterns and trends in the monthly data from 2010 to 2022, from which political and economic milestones such as the shutdown of nuclear power plants and the European Union's increased reliance on natural gas imports from Russia were examined. The study also discusses the impact of using natural gas for power generation on increasing GHG emissions. Ultimately, this research reveals that the European Union choices in transitioning towards a cleaner electricity mix have not yet proven efficient. In fact, these choices may have inadvertently created favorable conditions for Russia's invasion of Ukraine, triggering, not only a humanitarian crisis, but also an economic downturn in Europe due to soaring energy prices. This crisis could potentially extend beyond Europe and impact the whole planet in 2023, including developing countries that rely on stable energy prices for their sustainable growth.
Guided Waves in Ship Structural Health Monitoring – A Feasibility Study
Authors: Roch Emil , Zima Beata , Woloszyk Krzysztof , Garbatov Yordan 
Published: July 2023

Abstract
Ships and offshore structures operate in a severe corrosion degradation environment and face difficulty in providing long-lasting corrosion protection. The Classification Societies recommend regular thickness measurements leading to structural component replacements, to ensure structural integrity during service life. The measurements are usually performed using ultrasonic thickness gauges and such an approach requires multiple measurements of the corroded structural components. Otherwise, the collected data are insufficient to precisely assess the corrosion degradation level. This study aims to perform numerical and experimental analyses to verify the use of guided ultrasonic waves in defining the corrosion degradation level of the corroded structural components of a ship. The study incorporates the fundamental antisymmetric Lamb mode, excited by piezoelectric transducers attached at the pre-selected points on stiffened panels, representing typical structural ship components. The specimens are exposed to accelerated marine corrosion degradation, the influence of the degree of degradation on the wave time of flight being analysed. The study indicates that guided waves are a promising approach for diagnosing corroded structural components. The signals characterised by a high signal-to-noise ratio have been captured, even for relatively long distances between the transducers. This proves that the proposed approach can be suitable for monitoring more extensive areas of ship structures by employing a single measurement.
Diagnosis and treatment of external hemorrhoids on an outpatient basis
Authors: Lomonosov A. L. , Golubev A. A. , Kukanova M. A. , Khomenchuk A. A. , Khushakov A. H. , Lomonosov G. D. 
Published: July 2023

There are many variants of acute external hemorrhoids (AEH), with varying degrees of its development.The purposeof the study is to study the features of diagnosis and treatment of outpatient patients with AEH in the form of ovoid (AEH–FO).Material and methods. A solid sample, a retrospective sequential study of the data of 97 outpatient patients with AEH–FO. AEH–FO of the first degree (AEH–FO 1) was detected in 57,7% of patients, the node was more often elastic, blue in color, AEH–FO of the second degree (AEH–FO 2) in 42,3% of patients, wound necrosis on the node, the discharge of blood from it. In 32,7% of patients treated on average after 4 days, the average pain on the visual pain scale (VPS) was 6 points. Conservative treatment was carried out in all patients with AEH–FO with the appointment of MOFF (90% diosmin and 10% hesparin flavides. When bleeding from the node, tranexam, psyllium, lactulose, macrogol were prescribed for constipation. Analgesia was performed depending on the intensity of the pain. Only 3,1% of patients were operated on before 2018.Conclusions. The treatment of patients with AEH–FO was eﬀective. In the average treatment period of 14 days, all patients recovered and were able to work.
The Effect of In-situ Stress on Hydraulic Fractures Dimensions
Authors: Al Humairi Mohammed , Abdul Hadi Hassan 
Published: July 2023

Understanding of in-situ stress profiles and orientations plays a vital role in designing a successful hydraulic fracturing treatment. This paper is an attempet to examine the effect of lithology and in situ stress on geometery of hydraulic fractures. A hydraulic fracturing design simulator software called FracproPT with various capabilities for designing most of hydraulic fracture was used for simulate and optimize the hydraulic fracturing. For studying purpose, three different cases of stress gradient contrast between different formations are considered in this study (0.4, 0.5 and 0.75 psi/ft). The results obtained from the simulator showed that lithologies surrounding the pay zone have an effect on the fracture’s height, width, and length. Also, Maximum height is achieved when the stress contrast between the pay zone and the surrounding layers is very small.
Experimental Work to Study the Behavior of Proppant Inside the Hydraulic Fractures and the Plugging Time
Authors: Abdul Ameer Mohammed , Hamed Allah Samera 
Published: July 2023

Experiments were conducted to study the behavior of the solid particles (proppant) inside the hydraulic fracture during the formation stimulation, and study the effect of the proppant concentration on the hydraulic fracturing process, which lead to bridge and screen-out conditions inside the fractures across the fracture width that restricts fracturing fluid to flow into the hydraulic fracture. The research also studies the effect of the ratio between the fracture size and the average particles diameter “proppant", on fracture bridging. In this study two ratios were considered β= 2 and 3 ,where β=Dt / Dp where: Dt= hydraulic fracture size (width) and Dp=Average particles diameter.
This work presents experimental work to study the behavior of these particles (proppant) inside the hydraulic fractures by measuring the plugging time for different particles concentration for different conditions. The experimental data recorded for different particle concentration and one flowing forces (gravity) inside the hydraulic fracture. Most recorded experimental data obtained were analyzed by using SPSS software.
About some aspects of renewable energy (examples of use of renewable energy sources, lithium mining, electric transport)
Authors: Polak Yuri 
Published: July 2023

The review was prepared based on the analysis of dozens of sources in Russian and English on issues related to the transition to renewable energy sources in order to reduce greenhouse gas emissions, and the problems that arise during their operation. Attention is paid to conferences of specialists that have recently taken place under the auspices of the UN and in Moscow. On the basis of conversations with their participants, the difficulties of transition to new technologies are described, and the opinions of specialists are given. The role of lithium as a key component of batteries is emphasized. As an illustration of the problems of the &quot;green agenda&quot;, the situation with the automotive industry, which currently produces up to 40 % of environmental pollution, is described. The pros and cons of electric transport are discussed.
Jaws from the deep: biological and ecological insights on the kitefin shark Dalatias licha from the Mediterranean Sea
Authors: Bottaro Massimiliano , Sinopoli Mauro , Bertocci Iacopo , Follesa Maria Cristina , Cau Alessandro , Consalvo Ivan , Scarcelli Faustino , Sperone Emilio , Vacchi Marino , Marsili Letizia , Consales Guia , Danovaro Roberto 
Published: July 2023

Due to their late maturation, extreme longevity, low fecundity and slow growth rates, deep-sea Chondrichthyes are extremely vulnerable to human impacts. Moreover, assessing the impact of deep-sea fisheries is difficult, as many species (including sharks) are part of the bycatch and are often discarded at sea, and/or landed under generic commercial-species codes. The lack of this information on fishery data sets and the limited availability of species-specific life history data make challenging the management of deep-sea Chondrichthyes. The kitefin shark Dalatias licha is a cosmopolitan elasmobranch, mainly found on continental and insular shelf-breaks and slopes in warm-temperate and tropical waters. This species is a common by-catch of the deep-sea trawling, considered as “Endangered” by the IUCN Red List for all European waters, Mediterranean Sea included. Here we present the results of a study based on a total of 78 specimens of kitefin shark collected over 3 years in the Ligurian Sea (NW Mediterranean) as by-catch from deep-water fisheries. Total length ranged from 380 to 1164 mm, and individual weight ranged from 198 to 8000 g. Immature and mature individuals showed a sex ratio dominated by males. Adult males were observed throughout the year, while mature females were observed only in spring-summer. These data lead to hypothesise a spatial segregation between genders. The kitefin shark diet was dominated by bony fish (mainly Macrouridae) and other small sharks (e.g., Galeus melastomus and Etmopterus spinax), but their gut included plastic items and parasites. Data reported here underline the rarity, complex ecology and the threat for this shark species and support the urgency of promoting initiatives for their monitoring and conservation.
Antinuclear antibody (ANA) testing in primary care. The test is positive what now? A two-phase observational study of UK primary care
Authors: Evans Will , Vinogradova Yana , Pearce Fiona , Lanyon Peter , Kai Joe , Qureshi Nadeem 
Published: July 2023

BackgroundThe ANA-associated diseases are rare autoimmune diseases (including Systemic lupus erythematosus [SLE], Sjögren’s, Scleroderma, autoimmune hepatitis). Interpretation of ANA-tests is difficult, it is frequently positive in patients who do not appear to have an associated disease. In those who are ANA-positive we suspect there are features that can help distinguish those who will later develop disease.AimTo understand the characteristics of those tested, and in those who have positive features associated with disease development.MethodTwo phase study: 1) A case control study to examine characteristics of those tested. Cases defined as having had an ANA-test performed regardless of result, matched to controls who have never had an ANA test. 2) A cohort study of ANA-tested cases. In those who are ANA-positive, exposures (from literature, clinicians, and patients) will be used to predict the outcome ANA-associated disease.ResultsPhase 2:888,179 patients have at least one ANA-test performed: positive 22,587 (2.54%), negative 21,908 (2.47%), unknown 843,684 (94.99%).ANA-tested cohort.HR if positive: ANA-disease 5.15 (4.89 to 5.43); All-cause mortality 1.20 (1.16 to 1.24); CV mortality 1.20 (1.14 to 1.27) (adjusted HR (95% CI)).ANA-positive cohort. At 3 years 10.0% (9.7 to 10.5%) and at 20 year 15.7% (16.5 to 14.9% (95% CI) develop ANA-associated disease. HR for Female 2.29 (1.96 to 2.68); <55 years 1.53 (1.37 to 1.71) (adjusted HR (95% CI).ConclusionDefining the test result is difficult. However, there is clear differentiation between the positive and negative/unknown cohorts. Positive-test status is associated with ANA-disease development and mortality. If ANA-positive, most of those who will develop disease are diagnosed soon after testing; male gender and advanced-age reduce the risk of ANA-diseases.
La forme humaine
Authors: Berthelier Benoît 
Published: July 2023

La question « À quoi reconnaît-on un être humain ? » fait planer un certain doute sur notre capacité à reconnaître la forme humaine dans les multiples apparences que peut revêtir la vie. C’est sur fond de cette inquiétude sceptique, prenant acte du caractère instable, indistinct et pluriel de la vie humaine, que s’élaborent trois anthropologies philosophiques ici mises en dialogue : celle de Montaigne, de Nietzsche et de Wittgenstein. Ces trois auteurs ne se donnent pas tant pour objet la définition de l’homme que son indéfinition. Ils ne cherchent pas tant à savoir ce qu’est l’humain qu’à interroger le sens qu’il peut y avoir à formuler la question de ce qu’il est en termes de savoir. S’il y a un « humanisme » de Montaigne, de Nietzsche et de Wittgenstein, il n’est donc pas à chercher dans une thèse sur l’homme ou une profession de foi quant à sa dignité, mais dans l’élucidation ce que peut vouloir dire reconnaître l’humanité de l’humain au-delà de l’exigence métaphysique d’une définition de son essence, et de la déception sceptique qu’une telle exigence ne peut manquer de susciter.
Effective Health Communication and Required Competencies - the Case of Race and Gender Blindness in Major Online Health Information Sites
Authors: Omowumi Adekunle , Elizabeth Adekunle , Beloved Adekunle 
Published: July 2023

Purpose: The aim of the study was to examine effective health communication and required competences in addressing race and gender blindness in major online health information sites
Methodology: This study explored 8 online health information sites to examine their sensitivity to race and gender. The sites were searched for different health issues, some of the health issues present differently for people with different racial descents while some present differently for males and females.
Findings: Results from this study showed that 4 out of 8 sites had content only in English Language; 2 had content in 2 different languages; 1 had content in 4 languages, and 1 in 5 Languages. These sites made no gender distinction in the description of some diseases known to manifest differently by gender such as sexually transmitted infections and some of the sites made no racial distinction in the description of some diseases such as asthma and diabetes with different prevalence and fatality rate for people of different racial descents. All the sites used white people to illustrate disease conditions, including skin conditions whose coloration would differ for different skin colors. Blindness to these diversities would only result in failure to meet health information needs of the target audience. Health information must be sensitive to diversities.
Unique Contribution to Theory, Practice and Policy: The study recommends that there is a need to make information sensitive to diverse racial, cultural, gender and individual groups. It also recommends that more studie should be done on impact that underrepresentation of race, gender, and cultural diversity has on the receipt of health information being communicated by these sites.
Selumetinib (Koselugo)
Authors: CADTH  
Published: July 2023

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses selumetinib (Koselugo), 10 mg and 25 mg oral capsules.
Indication: For the treatment of pediatric patients aged 2 years and above, with neurofibromatosis type1 who have symptomatic, inoperable plexiform neurofibromas.