bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selenium‐binding protein 1 inhibits malignant progression and induces apoptosis via distinct mechanisms in non‐small cell lung cancer
Authors: Zhu Ying , Pu Qiang , Zhang Qiongyin , Liu Yang , Ma Yongfang , Yuan Yue , Liu Lunxu , Zhu Wen 
Published: August 2023

AbstractBackgroundSelenium is an essential trace element in the human body. In epidemiological and clinical studies, Se supplementation significantly reduced the incidence of lung cancer in individuals with low baseline Se levels. The significant action of selenium is based on the selenium‐containing protein as a mediator. Of note, the previous studies reported that the expression of selenium‐binding protein 1 (SELENBP1) was obviously decreased in many human cancer tissues including non‐small cell lung cancer (NSCLC). However, its roles in the origin and development of NSCLC are still unclear.MethodsThe expression of SELENBP1 was measured by qRT‐PCR, Western blotting and IHC in our collected clinical NSCLC tissues and cell lines. Next, the CCK‐8, colony formation, wound‐haeling, Millicell, Transwell, FCM assay, and in vivo xenograft model were performed to explore the function of SELENBP1 in NSCLC. The molecular mechanisms of SELENBP1 were investigated by Western blotting or IF assay.ResultsWe further identified that the expression of SELENBP1 was significantly decreased in NSCLC tissues in TCGA database and 45 out of 59 collected clinical NSCLC tissues compared with adjacent nontumor tissues, as well as in four NSCLC cell lines compared with normal lung cells. Particularly, we unexpectedly discovered that SELENBP1 was obviously expressed in alveolar type 2 (AT‐II) cells for the first time. Then, a series of in vitro experiments uncovered that overexpression of SELENBP1 inhibited the proliferation, migration, and invasion of NSCLC cells, and induced cell apoptosis. Moreover, overexpression of SELENBP1 also inhibited growth and induced apoptosis of NSCLC cells in vivo. Mechanistically, we demonstrated that overexpression of SELENBP1 inhibited the malignant characteristics of NSCLC cells in part via inactivating the PI3K/AKT/mTOR signal pathway. Meanwhile, we found that overexpression of SELENBP1 inducing the apoptosis of NSCLC cells was associated with the activation of caspase‐3 signaling pathway under nonhigh level of oxidative stress, but overexpression of SELENBP1 facilitating the cell apoptosis might be related to its combining with GPX1 and colocalizing in the nucleus under high level of oxidative stress.ConclusionsOur findings highlighted that SELENBP1 was an important tumor suppressor during the origin and development of NSCLC. It may help to discover novel biomarkers or drug therapy targets for NSCLC.
Coupled Electrochemical Processes as Versatile Route for Converting Waste Substrates into Value Added Chemical Products
Authors: Pichler Christian M. 
Published: August 2023

AbstractThere is a strong initiative in chemical industry to replace fossil resources by alternative feedstocks and implement more sustainable production routes for chemicals. Waste feedstocks are especially appealing, considering the principles of circular economy. They exhibit, however, great structural complexity, and it is challenging to convert them into defined chemical products. To still enable the conversion of waste feedstocks into value added chemicals, coupled catalytic processes are a viable solution. A first reaction step transforms the waste substrate into more defined and soluble intermediates which are subsequently converted into value added chemicals, in a second reaction step. Electrochemical reactions are of great interest for such processes, especially in the context of sustainability, as they can be powered by electricity from renewable sources and enable unique chemical transformations. In this review different strategies for converting waste substrates into value added chemicals are addressed by using process couplings including electrochemical reactions. Such coupled processes are of great interest to enable the transformation of chemical industry towards sustainable processes following the principles of circular economy.
BeSleep: Blockchain‐enabled distributed sleeping strategies of small base stations in ultra dense networks
Authors: Venkateswararao Kuna , Swain Pravati 
Published: August 2023

SummarySmall cell networks can fulfill the increasing demandfor the high data rate of wireless applications. Energy efficiency is an important design parameter of the ultra dense small cell network (UDSCN). The sleeping strategy of small base stations (s‐BSs) is used to enhance the network's energy efficiency. An efficient sleeping strategy of s‐BSs is required while preserving users' quality of service (QoS). The idle s‐BSs can be switched to sleep mode. This paper proposes a blockchain‐enabled solution for the sleeping strategy of s‐BSs. Here, a blockchain‐enabled small cell network is created between the s‐BSs. The network is decentralized, which eliminates the workload of the macro base station (MBS). The proposed network architecture is enabled as a decentralized network through blockchain. The blockchain provides distributed control over the s‐BS operations through a smart contract. Here, smart contracts act as distributed self organizing network features to handle self‐transactions among small cells for switching off s‐BSs in the network. All the software logic required to perform s‐BS operations is written in a smart contract using Ethereum. The proposed solution improves energy efficiency and enables the ultra dense small cell network to be decentralized.
A case of idiopathic gastroesophageal submucosal hematoma in a patient with no predisposition to bleeding
Authors: Iwado Takaaki , Honda Hirokazu , Gotoda Tatsuhiro 
Published: August 2023

AbstractGastroesophageal submucosal hematoma is a disease in which blood vessels in the gastroesophageal submucosa rupture and form a hematoma. In this report, we describe a case of gastroesophageal submucosal hematoma that developed due to vomiting in a patient with no history of bleeding and resolved with conservative treatment. A 69‐year‐old man presented with precordial pain and hematemesis after vomiting. A diagnosis of idiopathic gastroesophageal submucosal hematoma was made by computed tomography scan, magnetic resonance imaging, and esophagogastroduodenoscopy. Healing was achieved by conservative treatment with fasting, rehydration, and acid suppression. When a patient presents with sudden chest pain, hematemesis, and dysphagia, the possibility of this disease should be considered.
Confirmation of significant sea turtle nesting activity on a remote island chain in the Gulf of Mexico
Authors: Lamont Margaret M. , Ingram Dianne , Baker Todd , Weigel Matt , Shamblin Brian M. 
Published: August 2023

AbstractGlobally, six of the seven sea turtle species are threatened or endangered and as such, monitoring reproductive activity for these species is necessary for effective population recovery. Remote beaches provide a challenge to conducting these surveys, which often results in data gaps that can hamper management planning. Throughout the summer of 2022, aerial surveys were conducted over the Chandeleur Islands in the Gulf of Mexico. Turtle crawls were photographed for subsequent review by 10 expert observers. Whenever possible, ground surveys were conducted, and samples of unhatched eggs or dead hatchlings were collected. A summary of historic reports of sea turtle nesting activity at this site was also compiled. On 11 days between May 4, 2022, and July 30, 2022, photographs of 55 potential sea turtle crawls were taken. Observers identified 54 of those as being made by a sea turtle. There was high‐to‐moderate certainty that 16 of those crawls were nests, that 14 were made by loggerheads, and that two were made by Kemp's ridleys. Observers were least certain of species identification when surveys were conducted during rainy weather. Genetic analyses based on mitochondrial and nuclear DNA were conducted on samples from five nests and those analyses confirmed that three nests were laid by Kemp's ridleys and two were laid by loggerheads. Historic records from the Chandeleur Islands substantiate claims that the Chandeleurs have supported sea turtle nesting activity for decades; however, the consistency of this activity remains unknown. Our aerial surveys, particularly when coupled with imaging, were a useful tool for documenting nesting activity on these remote islands. Future monitoring programs at this site could benefit from a standardized aerial survey program with a seaplane so trends in nesting activity could be determined particularly as the beach undergoes restoration.
Fabrication and characteristics of electret ultrasonic‐sensor using laser patterning
Authors: Kobayashi Kakeru , Kawada Yoshiaki , Kageyama Kensuke 
Published: August 2023

AbstractIn this study, in an electret capacitor sensor (ECS), which is an electromechanical exchange device consisting of an electret sandwiched between two electrodes, ridges as spacers and grooves as gaps were formed in the PTFE (polytetrafluoroethylene) layer of the insulating electrode by laser ablation. The ECSs were then fabricated using PTFE electrets, and the charge retention and airborne ultrasonic wave transmitting and receiving characteristics were investigated. The charge retention characteristics of the ECS with laser‐patterned insulating electrodes were slightly lower than those of the silica‐aggregate electret. As the thickness of the insulating layer increased or the groove width decreased, the transmitting and receiving sensitivity increased significantly and then peaked and degraded at the measurements of transmitting and receiving. The ECS with the highest peak sensitivity obtained by laser patterning had a bandwidth comparable to that of the conventional ECS with silica aggregate electret, but the peak sensitivity was improved by up to 8 dB. Therefore, laser patterning could contribute to the improvement of ECS performance.
Pd‐Catalyzed [3+2]‐Dehydrogenative Annulation Reactions
Authors: Liu Yang , Roch Mikaël Le , Mori Alessia , Pradal Alexandre , Poli Giovanni , Oble Julie 
Published: August 2023

AbstractThe significance of cross dehydrogenative couplings has increased considerably in recent years. This article revisits the [3+2] C−C/N−C, C−C/O−C and C−C/C−C annulation strategy, recently reported by our group, according to a Pd(II) catalyzed dehydrogenative variant. Our original report relied on Pd(0) catalysis, using α,β‐unsaturated‐γ‐oxy carbonyls as bis‐electrophiles and resonance‐stabilized acetamides or 3‐oxoglutarates as C/N and O/C or C/C bis‐nucleophiles, respectively. In this more modern and straightforward Pd(II)‐catalyzed dehydrogenative approach, β,γ‐unsaturated carbonyl derivatives replace α,β‐unsaturated‐γ‐oxy carbonyls as bis‐electrophiles. Our study includes experimental optimization and showcases the synthetic versatility in the formation of diverse heterocyclic structures, such as bicyclic lactams, furo‐cycloalkanones and bicycloalkane‐diones. Furthermore, a mechanism is proposed to elucidate the underlying processes involved in these reactions.
Magnetohydrodynamic forced convection in bidisperse porous medium: Analysis of flow and temperature distributions in a parallel‐plate channel
Authors: Vanengmawia P. C. , Ontela Surender 
Published: August 2023

AbstractThis study aims to explore magnetohydrodynamic forced convection in a parallel‐plate channel filled with a bidisperse porous medium, while emphasizing the significance of viscous dissipation. The study utilizes the two‐velocity two‐temperature model to analyze the flow and temperature distributions in both the fluid phase and solid phase. Convective boundary conditions at the channel walls are considered, and momentum slip is incorporated into the analysis. By nondimensionalizing the governing equations and employing the Homotopy Analysis Method, the velocity and temperature profiles for both phases are determined. Notably, the findings of the study highlight a notable discrepancy in the temperature increase between the solid phase and the fluid phase. Furthermore, the study investigates the impact of various parameters, such as the Darcy number, Biot number, slip parameter, Hartmann number, and Brinkman number, on velocity, temperature, Nusselt number, and skin friction.
Mechanobiological cell adaptations to changing microenvironments determine cancer invasiveness: Experimentally validated finite element modeling
Authors: Tulchinsky Marina , Weihs Daphne 
Published: August 2023

AbstractMetastases are the leading cause of cancer‐associated deaths. A key process in metastasis is cell invasiveness, which is driven and controlled by cancer cell interactions with their microenvironment. We have previously shown that invasive cancer cells forcefully push into and indent physiological stiffness gels to cell‐scale depths, where the percentage of indenting cells and their attained depths provide clinically relevant predictions of tumor invasiveness and the potential metastatic risk. The cell‐attained, invasive indentation depths are directly affected by gel‐microenvironment mechanics, which can concurrently modulate the cells' mechanics and force application capacity, in a complex, coordinated mechanobiological response. As it is impossible to experimentally isolate the different contributions of cell and gel mechanics to cancer cell invasiveness, we perform finite element modeling with literature‐based parameters. Under average‐scale, cell cytoplasm and nucleus mechanics and cell‐applied force levels, increasing gel stiffness 1–50 kPa significantly reduced the attained indentation depth by >200%, while the gel's Poisson ratio reduced depths only by up to 20% and only when the ratio was >0.4; this reveals microenvironment mechanics that can promote invasiveness. Experiments with varying‐invasiveness cancer cells exhibited qualitative variations in their responses to gel stiffness increase, for example large/small reduction in indentation depth or increase and then reduction. We quantitatively and qualitatively reproduced the different experimental responses via coordinated changes in cell mechanics and applied force levels. Thus, the different cancer cell capacities to adapt their mechanobiology in response to mechanically changing microenvironments likely determine the varying cancer invasiveness and metastatic risk levels in patients.
Coarse‐graining kinetic networks in photosynthetic energy transport
Authors: Yang Yun‐Chung , Hong Jia‐Cheng , Wang Jun 
Published: August 2023

AbstractPhotosynthetic systems utilize hundreds of chlorophylls to collect sunlight and transport the energy to the reaction center with remarkably high quantum efficiency, however, the large size of the system together with the complex interactions among the components make it extremely challenging to understand the dynamics of light harvesting in large photosynthetic systems. To shed light on this problem, we present a structure‐based theoretical framework that can be used to calculate transition rate matrix describing energy transport in photosynthetic systems and network clustering methods that provide simplified coarse‐grained model revealing key structures guiding the light harvesting process. We constructed an effective model for energy transport in a Photosystem II supercomplex and applied several network clustering methods to generate coarse‐grained kinetic cluster models for the system. Furthermore, we evaluated the performances of the network clustering methods, and show that a spectral clustering method and a minimum cut approach produce accurate coarse‐grained models for the PSII‐sc system. The results indicate that finding bottlenecks of energy transport is a crucial factor for reduced representations of photosynthetic light harvesting, and the overall work presented in this paper should provide a comprehensive theoretical framework to elucidate the dynamics of light harvesting in photosynthetic systems.
Combined effects of dietary carbohydrate levels and ammonia stress on growth, antioxidant capacity and glucose metabolism in juvenile oriental river prawn (Macrobrachium nipponense)
Authors: Wei Shanshan , Liu Ting , Zhao Yani , Xiao Yang , Zhou Dongsheng , Zheng Jinxian , Zhou Dong , Ding Zhili , Xu Qiyou , Limbu Samwel Mchele , Kong Youqin 
Published: August 2023

AbstractAmmonia is a common environmental stress factor that constrains aquaculture industry development. This study evaluated the effect of carbohydrate levels and ammonia stress in oriental river prawn (Macrobrachium nipponense). The experiment had six treatments containing two water ammonia levels (0 and 5 mg/L) and three dietary carbohydrate levels (low carbohydrate diet (LCD, 10%), medium carbohydrate diet [MCD, 20%], and high carbohydrate diet [HCD, 30%]), and lasted six weeks. The results showed that the prawns fed on MCD had higher weight gain than those fed on LCD and HCD during ammonia stress. Moreover, the prawns fed on MCD had significantly lower acid phosphatase and alkaline phosphatase activities during ammonia stress. Feeding the prawns on the MCD increased B cells in the hepatopancreas during ammonia stress. Interestingly, the prawns fed on MCD had significantly lower superoxide dismutase activity compared to LCD and HCD during ammonia stress. Moreover, the prawns fed on MCD had significantly lower pyruvate kinase activity and pyruvate and lactic acid contents, while those fed on LCD had significantly higher succinic dehydrogenase, 6‐phosphogluconic dehydrogenase, and phosphoenol pyruvate carboxykinase activities during ammonia stress. The prawns fed on the MCD increased significantly glutaminase activity and decreased the ammonia content in the serum during ammonia exposure. In addition, feeding the prawns on MCD decreased significantly the expression of apoptosis and inflammation‐related genes. Taken together, the MCD supplied energy required to counteract ammonia stress, which increased growth, improved antioxidant capacity, facilitated ammonia excretion, and alleviated inflammation and apoptosis of the oriental river prawn.
Development of an ubiquitin‐proteasome system signature for predicting prognosis and providing therapeutic guidance for patients with triple‐negative breast cancer
Authors: Chen Xiaoqing , Ren Chongyang , Zhou Zhisheng , Chen Jiewen , Fan Xulong , Li Xiangzhi , Chen Jintao , Zhu Jing 
Published: August 2023

AbstractBackgroundTriple‐negative breast cancer (TNBC) is a pathological subtype with a high mortality, and the development of inhibitors in the ubiquitin–proteasome system (UPS) component could be a novel therapeutic tool.MethodsTriple‐negative breast cancer data were obtained from The Cancer Genome Atlas (TCGA), and subtype analysis was performed by consistent clustering analysis to identify molecular subtypes of TNBC according to UPS characteristics. Differential analysis, COX and least absolute shrinkage and selection operator (LASSO) COX regression analyses were performed to select genes associated with overall survival in TNBC. The final prognostic model (UPS score) was determined using the LASSO COX model. The model performance was assessed using receiver operating characteristic (ROC) curves and survival curves. In addition, the results of the UPS score on analyzing the abundance of immune cell infiltration and immunotherapy were explored. Finally, we developed a nomogram for TNBC survival prediction.ResultsTwo UPS subtypes (UPSMS1 and UPSMS2) showing significant survival differences were classified. COX regression analysis on differentially expressed genes in UPSMS1 and UPSMS2 filtered five genes that affected overall survival. Based on the regression coefficients and expression data of the five genes, we built a prognostic assessment system (UPS score). The UPS score showed consistent prognostic and therapeutic guidance values. Finally, the ROC curve of the nomogram and UPS score showed the highest predictive efficacy compared with traditional clinical prognostic indicators.ConclusionThe UPS score represented a promising prognostic tool to predict overall survival and immune status and guide personalized treatment selection in TNBC patients, and this study may provide a more practical alternative for clinical monitoring and management of TNBC.
LC–MS methods combination for identification and quantification of trans‐sinapoylquinic acid regioisomers in green coffee
Authors: Colomban Silvia , De Rosso Mirko , Flamini Riccardo , Navarini Luciano 
Published: August 2023

AbstractThe present study aims to both identify and quantify trans‐sinapoylquinic acid (SiQA) regioisomers in green coffee by combined UHPLC‐ESI‐QqTOF‐MS/MS and UHPLC‐ESI‐QqQ‐MS/MS methods. Among the various mono‐acyl chlorogenic acids found in green coffee, SiQA regioisomers are the least studied despite having been indicated as unique phytochemical markers of Coffea canephora (known as Robusta). The lack of commercially available authentic standards has been bypassed by resorting to the advantages offered by high‐resolution LC–MS as far as the identification is concerned. SiQA regioisomers have been identified in several samples of Robusta and Coffea arabica (known as Arabica) commercial lots from different geographical origin and, for the first time, in different samples of coffee wild species (Coffea liberica and Coffea pseudozanguebariae). Quantification (total SiQA ranging from 3 to 5 mg/100 g) let to reconsider these chlorogenic acids as unique phytochemical markers of Robusta being present in the same quantity and distribution in C. liberica as well. Gardeniae Fructus samples (fruits of Gardenia jasminoides) have additionally been characterized as this matrix is recognized as one of the few naturally occurring SiQA sources. The SiQA regioisomer content (total SiQA about 80 mg/100 mg) fully supports the proposal to use this matrix as a surrogate standard for further studies.
Changes of the streamflow of northern river basins of Siberia and their teleconnections to climate patterns
Authors: Zhang Shuyu , Gan Thian Yew , Bush Andrew B. G. , Liu Junguo , Zolina Olga , Gelfan Alexander 
Published: August 2023

AbstractThe Arctic rivers contribute more than one‐third of the total freshwater streamflow into the Arctic Ocean and play an essential role in the heat and mass circulation of the Arctic atmosphere/ocean system. As the Arctic is warming faster than the global average, the streamflow from Arctic basins increases. This study analyzed the streamflow of the three largest Siberian rivers: the Lena, Yenisei, and Ob', at multiple temporal scales. Results show that the annual streamflow of each river basin exhibits statistically significant increasing trends, while the seasonal streamflow of sub‐basins generally decreases in the summer but increases in the winter. Both autocorrelation and long‐term persistency are often found in the streamflow time series, which indicates significant changes in the large‐scale climatological environment. Therefore, wavelet coherence between the streamflow and large‐scale climate patterns, including the El Niño–Southern Oscillation (ENSO), North Pacific pattern (NP), Arctic Oscillation (AO), and the Pacific/North America Pattern (PNA), have been conducted. NP and ENSO are found to have positive relationships with the precipitation and the ratio of potential evapotranspiration over the precipitation. AO and the PNA are found to have positive relationships with the streamflow of the Ob' and Yenisei rivers at decadal and multidecadal scales. This study demonstrates that the existence of nonstationarities within the Siberian streamflow as the combined impact of climate change alters the hydroclimatological and terrestrial environment of Siberia. These findings provide new insights into the mechanisms underlying the hydrologic changes to warming trends and oscillations of climate patterns, which contribute to our understanding and the prediction of streamflow of these northern rivers.