bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development, Implementation, and Usability Evaluation of a Chatbot to Effectively Provide Information on the Human Papillomavirus Vaccine
Authors: Alzughaibi Saleh , Luo Jake , Nazareth Derek , Wu Min , Fink Jennifer T. 
Published: April 2023

Abstract
The Human papillomavirus (HPV) vaccine has been shown to provide protection against HPV infections, which can cause genital warts and some forms of cancer. Lack of information about the virus and the vaccine represents one of the major challenges to reaching national HPV vaccination goals. Advancements in natural language processing have facilitated the effectiveness of chatbots in interacting with users. Chatbots have been increasingly employed in health and medical care settings, assisting physicians during consultations, helping with behavior change issues, and supporting patients and the elderly in their daily lives. A potential opportunity to improve vaccination rates is to provide health information through unconventional methods by utilizing chatbots. This work describes the design, implementation, and evaluation of a chatbot called GARDI, created to disseminate information about HPV infection and vaccine. The Chatbot Usability Questionnaire (CUQ) was employed to evaluate GARDI. The mean CUQ score was 66.6, which is marginally below the suggested benchmark for evaluation of chatbots. An examination of CUQ subscales indicated that GARDI was considered to be easy to use and navigate, provided useful, appropriate, and informative responses, and welcoming in nature.
Liposome doxorubicin attenuates cardiotoxicity by reducing ferritinophagy
Authors: Yu Yating , Niu Haiyue , Zhang Mengying , Liu Mengyuan , Zhang Yue , Yang Jinyue , Liu Yumei , Xing Limin , Shao Zonghong , Fu Rong , Wang Huaquan 
Published: April 2023

Abstract
Background
Doxorubicin (DOX) is widely used in lymphoma, myeloma, breast cancer, and other malignant tumors, and it significantly improves the prognosis of these patients. However, its side effects, especially cardiotoxicity, must be taken seriously. Studies have shown that liposome doxorubicin (L-DOX), compared with DOX, has increased anti-tumor activity and decreased cardiac toxicity. Our aim is to investigate the mechanism of myocardial injury in mice caused by these two drugs, to identify potential mitigation strategies.
Methods
In this study, mice or HL-1 cells were treated with DOX or L-DOX, and the cardiac morphology, hemodynamic effect, laboratory examination, and expression of ferritinophagy-related proteins were compared with the control group.
Results
DOX significantly induced myocardial cell death, while L-DOX had little effect on myocardial injury. Additionally, DOX significantly increased the level of autophagy and ferroptosis in cardiac myocytes. Further analysis revealed that NCOA4-mediated ferritinophagy played a key role in the mechanism of doxorubicin-induced cardiotoxicity (DIC). Importantly, the addition of ferrostatin-1 (a ferroptosis inhibitor) was able to rescue DIC. In contrast, L-DOX reduced the damage to cardiac myocytes by reducing ferritinophagy.
Conclusion
We have found that a significant relationship between the mechanism of DIC and NCOA4-mediated ferritinophagy. L-DOX has been shown to reduce the damage to myocardial cells by reducing NCOA4-mediated ferritinophagy. Thus, NCOA4 has the potential to be a drug target for the cardiac protection of DIC. However, further research is need to investigate the specific role of NCOA4 in the pathogenesis of DIC.
Seascape connectivity: ontogenetic migration model for Haemulon flavolineatum
Authors: Rodriguez-Torres Carolina , Acosta Alberto 
Published: April 2023

Abstract

In the seascape, species migrate between ecosystems to complete their life cycles, such ontogenetic migrations create functional connections between ecosystems. Nevertheless, the scarcity of information on patch distribution, species life history and ecology limit its application in MPA management. We use a potential connectivity model approach to predict how Haemulon flavolineatum might move through a complex and diverse seascape, by simulating part of its life cycle among three ecosystems (reef, mangrove, and seagrass) in the MPA of Bahía Portete-Kaurrele (BPK). We used available ecosystem cover maps to conduct habitat fragmentation analyses and evaluate structural connectivity in BPK (PLAND, LPI, AREA, ENN, NP, SHAPE, CONTAG and IJI indices). With published information on H. flavolineatum home range and its ontogenetic migration distances, we estimated the potential functional connectivity (CONNECT and migration distances) between ecosystems by building bipartite graphs. Patches of different ecosystems were highly intermixed (76%) rather than grouped (58%) reflecting appropriate structural connectivity; particularly for reefs followed by mangrove and seagrass; this seascape promote the potential migration of stage 5, juveniles from mangroves to the reefs (328 links, mainly in the BPK’s southern zone). Meanwhile, the structural configuration could reduce functional connectivity of stage 4 juveniles from seagrass to mangrove (mainly in the northern and central zone; 94 and 49 links respectively). Our model is a novel methodological approach for marine species with ontogenetic migration, which integrates ecological information and the seascape to predict their life cycle. We discuss the need for ecological information of French grunts to validate future models.
Troubleshooting Design of the Drainage Pipe Treatment Project of the Higher Education Expo Park in Ouhai District, Wenzhou City
Authors: Bai Fang , Hai-zhong Yu , Ran-mao Hu 
Published: April 2023

Abstract
Taking the Higher Education Expo Park in Ouhai District, Wenzhou City as an example, this paper introduced the troubleshooting and design process of the drainage pipe treatment project (non-direct sewage discharge project) for residential areas. The analysis of troubleshooting results, project design ideas and specific design methods were also described in detail. Through the analysis on COD sampling results before and after transformation of the project, the project had achieved a very good rain-sewage diversion effect and the design purpose. It had been proved that the combination of troubleshooting and design was an effective mode for the drainage pipeline treatment projects.
Machine Learning Applications for Early Detection of Esophageal Cancer: A Systematic Review
Authors: Hosseini Farhang , Asadi Farkhondeh , Emami Hassan , Ebnali Mahdi 
Published: April 2023

Abstract
Introduction: Esophageal cancer (EC) is a significant global health problem, with an estimated 7th highest incidence and 6th highest mortality rate. Timely diagnosis and treatment are critical for improving patients' outcomes, as over 40% of patients with EC are diagnosed after metastasis. Recent advances in machine learning (ML) techniques, particularly in computer vision, have demonstrated promising applications in medical image processing, assisting clinicians in making more accurate and faster diagnostic decisions. Given the significance of early detection of EC, this systematic review aims to summarize and discuss the current state of research on ML-based methods for the early detection of EC.
Methods: We conducted a comprehensive systematic search of five databases (PubMed, Scopus, Web of Science, Wiley, and IEEE) using search terms such as "ML", "Deep Learning (DL(", "Neural Networks (NN)", "Esophagus”, “EC" and “Early Detection”. After applying inclusion and exclusion criteria, 31 articles were retained for full review.
Results: The results of this review highlight the potential of ML-based methods in the early detection of EC. The average accuracy of the reviewed methods in the analysis of endoscopic and computed tomography (CT (images of the esophagus was over 89%, indicating a high impact on early detection of EC. Additionally, the highest percentage of clinical images used in the early detection of EC with the use of ML was related to white light imaging (WLI) images. Among all ML techniques, methods based on convolutional neural networks (CNN) achieved higher accuracy and sensitivity in the early detection of EC compared to other methods.
Conclusion: Our findings suggest that ML methods may improve accuracy in the early detection of EC, potentially supporting radiologists, endoscopists, and pathologists in diagnosis and treatment planning. However, the current literature is limited, and more studies are needed to investigate the clinical applications of these methods in early detection of EC. Furthermore, many studies suffer from class imbalance and biases, highlighting the need for validation of detection algorithms across organizations in longitudinal studies.
Frequent Upregulation Of HER2 Protein In Hormone Receptor-Positive HER2-Negative Breast Cancer After Short-Term Neoadjuvant Endocrine Therapy
Authors: Chaudhary Lubna Naaz , Jorns Julie , Sun Yunguang , Cheng Yee Chung , Kamaraju Sailaja , Burfeind John , Gonyo MaryBeth , Kong Amanda , Patten Caitlin , Yen Tina , Cortina Chandler , Carson Ebony , Johnson Nedra , Bergom Carmen , Tsaih Shirng-Wern , Banerjee Anjishnu , Wang Yu , Chervoneva Inna , Weil Elizabeth , Chitambar Christopher R , Rui Hallgeir 
Published: April 2023

Abstract
Background. Endocrine resistant metastatic disease develops in ~20-25% of hormone-receptor positive (HR+) breast cancer (BC) patients despite endocrine therapy (ET) use. Upregulation of HER family receptor tyrosine kinases (RTKs) represent escape mechanisms in response to ET in some HR+ tumors. Short-term neoadjuvant ET (NET) offers the opportunity to identify early endocrine escape mechanisms initiated in individual tumors.
Methods. This was a single arm, interventional phase II clinical trial evaluating 4 weeks (+/-1 week) of NET in patients with early-stage HR+/HER2-negative (HER2-) BC. The primary objective was to assess NET-induced changes in HER1-4 proteins by immunohistochemistry (IHC) score. Protein upregulation was defined as an increase of ≥1 in IHC score following NET.
Results. Thirty-seven patients with cT1-T3, cN0, HR+/HER2- BC were enrolled. In 35 patients with evaluable tumor HER protein after NET, HER2 was upregulated in 48.6% (17/35; p=0.025), with HER2-positive status (IHC 3+ or FISH-amplified) detected in three patients at surgery, who were recommended adjuvant trastuzumab-based therapy. Downregulation of HER3 and/or HER4 protein was detected in 54.2% of tumors, whereas HER1 protein remained low and unchanged in all cases. While no significant volumetric reduction was detected radiographically after short-term NET, significant reduction in tumor proliferation rates were observed. No significant associations were identified between any clinicopathologic covariates and changes in HER1-4 protein expression on multivariable analysis.
Conclusion. Short-term NET frequently and preferentially upregulates HER2 over other HER-family RTKs in early-stage HR+/HER2- BC and may be a promising strategy to identify tumors that utilize HER2 as an early endocrine escape pathway.
Trial registration number: NCT03219476
Date of registration for prospectively registered trials: July 17, 2017
Difference in the cumulative incidence of aneurysmal occlusion by Flow Re-direction Endoluminal Device and Pipeline Embolization Device in the treatment of unruptured internal carotid artery aneurysms: A propensity score-matched cohort study
Authors: Matsukawa Hidetoshi , Uchida Kazutaka , Rajbhandari Saujanya , Shirakawa Manabu , Yoshimura Shinichi 
Published: April 2023

Abstract

Object:The introduction of flow diverters (FDs) has represented a paradigm shift in the management of unruptured cerebral aneurysms (UCA). Flow Re-Direction Endoluminal Devices (FREDs) and Pipeline Embolization Devices (PEDs) have gained widespread popularity. We aimed to investigate the cumulative incidence of aneurysm occlusion.Methods:A total of 195 patients with 199 UCAs were analyzed retrospectively. The outcomes were aneurysmal occlusion during the follow-up, a modified Rankin Scale score of 0–2 at 90-day, additional treatment, and major stroke, and steno-occlusive events of FD. Propensity score-matched analysis was performed controlling for age, sex, aneurysmal size, and location of internal carotid artery (ICA) aneurysm. Non-ICA aneurysms were excluded from matching.Results:During the follow-up period (median, 366 days), complete and satisfactory aneurysmal occlusions were observed in 128 (68%) and 148 (78%) of 189 UCAs in unmatched cohort. The 142 (71 each) propensity score-matched cohort was complied. The FRED group had a higher cumulative incidence of ICA aneurysm occlusion (complete: HR 2.7, 95% CI 1.4–5.1, p=0.0025; satisfactory: HR 2.4, 95% CI 1.1–5.2, p=0.025). Proportion of additional treatment was significantly smaller in the FRED group (OR 0.077, 95% CI 0.010-0.57, p=0.0007). Other outcomes showed no significant differences.Conclusion:Propensity score-matched analysis showed that FRED had a higher cumulative incidence of aneurysmal occlusion in the treatment of unruptured ICA aneurysms. Whether a cumulative incidence of aneurysmal occlusion may differ by the type of FDs warrants further investigation.
Approximations of Parallel Surfaces Along Curves
Authors: Köse Büşra , Yaylı Yusuf 
Published: April 2023

Abstract
In this paper, we study developable surfaces which are flat and normal approximation of parallel surfaces along curves associated with three special vector fields. We investigate singularities of such developable surfaces. We show that under what conditions the approach surfaces are parallel. Also, we show that the approach surfaces are constant angle ruled surfaces if the curves selected on the surfaces are isophote, relatively normal-slant helix and helix.
Mathematics Subject Classification (2010). Primary 53Axx; Secondary 57R45.
Enforcement of environmental protection protocols and compliance amongst Micro Small and Medium Enterprises inZimbabwe: Is institutional credibility effectual in the presence of corruption tendencies?
Authors: Kairiza Terrence , Chigusiwa Lloyd , Kavu Ambrose , Sonobe Tetsushi 
Published: April 2023

Abstract

There are growing concerns surrounding the environmental degradation that is caused by the operations of the expanding Micro, Small, and Medium Enterprises (MSMEs) engaged in manufacturing activities in developing countries. This is more so given the weak regulatory environments and low levels of institutional trust amongst entrepreneurs in a context where the potential to bribe environmental enforcement agents is rife as in a sizeable number of developing countries. We investigate the efficacy of regulatory inspections in inducing compliance with environmental protection standards and the heterogeneity that is brought about by institutional trust and corruption based on a nationally representative survey of MSMEs engaged in manufacturing activities in Zimbabwe. We deal with the problem of the endogeneity of regulatory inspections by using the doubly robust Inverse Probability Weighted Regression Adjusting method. We offer four major findings: First, regulatory inspections induce MSMEs’ compliance with environmental protection standards. Second, the impact of regulatory inspections on compliance with environmental protection standards is higher when MSMEs’ owners trust the regulatory institutions than when they do not. Third, regardless of the level of trust in institutions by entrepreneurs, the potential for entrepreneurs to bribe the regulatory agency officers subdues the potency of regulatory inspections in inducing compliance with environmental protection standards. Finally, in the absence of trust in the institutions by entrepreneurs, regulatory inspections on environmental protection standards have no statistically significant effect on compliance for corrupt entrepreneurs.
JEL: D22; K32; L51; Q56; Q58
Efficacy of using Maryland forceps versus electrocoagulation hooks in da Vinci robot-assisted thoracoscopic mediastinal tumor resection
Authors: Hong Ziqiang , Bai Xiangdou , Sheng Yannan , Cui Baiqiang , Lu Yingjie , Cheng Tao , Wu Xusheng , Jin Dacheng , Gou Yunjiu , Zhao Jing 
Published: April 2023

Abstract

Background To compare the difference of short-term curative effect between the use of Maryland forceps (MF) and electrocoagulation hooks (EH) in da Vinci robot-assisted thoracoscopic mediastinal tumor resection. Methods Analyze retrospectively 84 patients with mediastinal tumors treated with robot-assisted thoracoscopic surgery (RATS) at the Department of Thoracic Surgery of Gansu Provincial Hospital from February 2019 to February 2023. Two groups were divided according to the intraoperative use of energy devices, including 41 cases in the MF group and 43 cases in the EH group. Perioperative clinical data were collected to compare the recent outcomes of patients in both groups. Results There were no statistically significant differences between the two groups in terms of baseline indicators such as sex, age, and tumor size. Compared with the EH group, patients in the MF group have lower operative time, intraoperative bleeding, postoperative hospital stay and the levels of IL-6, IL-8, TNF-α, and cortisol were lower in the MF group than that in the EH patients, with statistically significant differences (P < 0.05). Conclusion RATS for mediastinal tumors using MF is safe and effective, which can reduce the amount of bleeding and reduce the degree of inflammatory reaction.
Epidemic trends of dyslipidemia in young adults: a real-world study including more than 20,000 samples
Authors: Liu Liang-Yu , Zheng Ying-Ying , Aimaiti Xiyidan , Zhi Xiao-Yu , Wang Zhi-Long , Yin Xin , Pan Ying , Wu Ting-Ting , Xie Xiang 
Published: April 2023

Abstract
Background
There is an urgent need to learn more about the epidemiological features of dyslipidemia in youth, in order to address the high burden of cardiovascular disease.
Methods
This experiment was an observational, cross-sectional study. The samples were collected from 22,379 college students in Xinjiang Medical University.
Result
The overall prevalence of dyslipidemia was 13.17%, significantly higher in men (23%) than in women (7.2%). Similarly, the proportion of obesity in men (32.6%) was significantly higher than that in women (24.1%). The composition of blood lipids, such as triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) began to increase gradually from the age of 22 and showed a sharp increase after the age of 30, however a reverse trend was presents in high density lipoprotein cholesterol (HDL-C). In terms of the proportion of dyslipidemia in both men and women, low HDL-C accounted for the largest proportion (74%), followed by TG (14.5%). The overall distribution of the incidence of dyslipidemia, so as to the ratios of low HDL-C and excess weight showed a U-shaped trend with age growing, which presents the lowest in the 20–24 age group.
Conclusion
Our study confirmed the crucial role of low HDL-C to dyslipidemia and reveal the U-shaped trend of obesity and dyslipidemia in young adults. Based on our results, we suggest age 22 to be the key time node for early intervention. This study enriches the limited data available on dyslipidemia and provides a reference for close monitoring and control of risk factors to reduce the occurrence and progression of atherosclerotic cardiovascular disease event.
ADAMTS12 mediates vascular abnormality to enhance chemoresistance via the MAPK/VEGF signaling pathway in gastric cancer
Authors: Jiang Yingming , Huang Jintuan , Huang Zhenze , Tan Rongchang , Li Tuoyang , Chen Zijian , Tang Xiaocheng , Zhao Yandong , Qiu Jun , Li Chujun , Chen Hao , Yang Zuli 
Published: April 2023

Abstract
Purpose: A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12) is involved in the angiogenesis and tumorigenesis of gastrointestinal cancer. However, the exact molecular and biological mechanisms of ADAMTS12 in gastric cancer (GC) remain unclear. This study aims to explore the exact underlying mechanisms of ADAMTS12 and provide a biomarker for prognosis and chemotherapy in GC.
Methods: Gain- and loss-of-function assays were used to reveal the effect of ADAMTS12 on cell proliferation, migration, invasion, tube formation and chemoresistance in vitro and in vivo. IHC was used to analyze the expression and the correlation between ADAMTS12, VEGF and CD31 in gastric cancer tissues with or without neoadjuvant chemotheraphy.
Results: ADAMTS12 promotes cell proliferation, angiogenesis and chemoresistance in vitro and in vivo. ADAMTS12 upregulates VEGF expression through ERK activation, which in turn, promoting angiogenesis and reducing sensitivity to oxaliplatin in GC. In GC tissues, ADAMTS12 was positively correlated with VEGF and microvessel density (MVD). Furthermore, patients with high ADAMTS12 level had poor overall survival (OS) and poor response to neoadjuvant chemotherapy.
Conclusion: ADAMTS12 enhances chemoresistance to oxaliplatin in normoxic and hypoxic microenvironments via the MAPK/VEGF signaling pathway in GC. High ADAMTS12 levels have prognostic significance for poor survival, and indicator of vascular abnormality and chemoresistance in GC.
Are tax rates still decisive in FDI investment choice or what drives sectoral FDI nowadays? *
Authors: Ianc Nicolae-Bogdan 
Published: April 2023

Abstract
We explore the eects of eective taxation and institutional quality on sec-toral FDI. Our analysis comprises European countries and we use data from 2002 to 2020. We employ a GMM approach and show that a rise in apparent taxation and tax dierential reduces sectoral FDI ow while soaring tax dierential increases FDI stock. Among the institutional variables, tertiary enrollment attracts FDI and secondary attainment has opposite results depending on the sectoral FDI. Our ndings indicate that government should lower taxation for more FDI ows and strengthen tertiary and secondary enrollment.
Comprehensive Analysis of Android Malware detection through Semi-supervised Autoencoder models
Authors: Firoz Neda , Firoz Abdullah Bin , Tahsin Mohammad Sadman 
Published: April 2023

Abstract
Recent years have seen a rapid proliferation of malicious software on mobile devices, notably repackaged Android malware. Grasping Android malware detection via vibrant analysis will provide a thorough read, but we must also establish a connection between the app's features and the elements required to fulfill the category's functionality. In this work, we propose a novel method of detecting malwares. This model is a part of semi-supervised learning. We employed autoencoder training features from noisy input. They generate clusters of malicious predictions utilizing the reconstruction error and helped in dimensionality reduction of the large feature set. The newly reconstructed input features are then fed to the machine learning model and Deep learning models for supervised prediction. Later, we contrast their performance based on performance metrics and accuracy. Three datasets were chosen for this experiment to assess the execution and operation of the proposed model. There were two labels in the ‘class’ attribute such as ‘0’ as Benign and ‘1’ as Malicious. The proposed model achieved superior accuracy and can deliver promising results.