bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping Patient Encounters in Breast Cancer Care
Authors: Sergesketter Amanda R. , Mundy Lily R. , Geng Yisong , Shammas Ronnie L. , Langdell Hannah C. , Wang Sabrina M. , Njoroge Moreen , Stukes Bryanna , Hollenbeck Scott T. 
Published: March 2023

Background
Transitions toward value-based systems require a comprehensive definition of the complexity and duration of provider effort required for a given diagnosis. This study modeled the numbers of clinical encounters involved in various treatment pathways among breast cancer patients undergoing mastectomy.

Methods
Clinical encounters with medical oncologists, radiation oncologists, breast surgeons, or plastic surgeons ≤4 years after diagnosis among all patients undergoing mastectomy from 2017 to 2018 were reviewed. Relative encounter volumes were modeled each 90-day period after diagnosis.

Results
A total of 8807 breast cancer–related encounters from 221 patients were analyzed, with mean (SD) encounter volume 39.9 (27.2) encounters per patient. Most encounters occurred in the first year after diagnosis (70.0%), with years 2, 3, and 4 representing 15.8%, 9.1%, and 3.5% of encounters, respectively. Overall stage was associated with encounter volume, with higher encounter volume with increasing stage (stages 0: 27.4 vs I: 28.5 vs II: 48.4 vs III: 61.1 vs IV: 80.8 mean encounters). Body mass index (odds ratio [OR], 0.22), adjuvant radiation (OR, 6.8), and receipt of breast reconstruction (OR, 3.5) were also associated with higher encounter volume (all P’s < 0.01). Duration of encounter volume varied by treatment phases, with medical oncology and plastic surgery sustaining high clinical encounter volume 3 years after diagnosis.

Conclusions
Encounter utilization in breast cancer care persists 3 years after index diagnosis and is influenced by overall stage and treatment characteristics, including receipt of breast reconstruction. These results may inform the design of episode durations within value-based models and institutional resource allocation for breast cancer care.
Change in CT Value at Mandibular Ramus After Mandibular Setback and Advancement Surgery With Bicortical Absorbable Plate Fixation
Authors: Ueki Koichiro , Moroi Akinori , Takayama Akihiro , Gomi Karen , Takekawa Takahiro , Yoshizawa Kunio 
Published: March 2023

Purpose:
This study aimed to evaluate changes in computed tomography (CT) value of ramus bone after sagittal split ramus osteotomy (SSRO) in class II and class III patients using absorbable plates and screws.

Patients and Methods:
In the retrospective study, the participants were female patients with jaw deformities who underwent bilateral SSRO with Le Fort I osteotomy. Maximum CT values (pixel values) of lateral and medial cortexes at anterior and posterior sites of the ramus were measured preoperatively and 1 year postoperatively by using horizontal planes at the mandibular foramen level (upper level) and 10 mm under the mandibular foramen level (lower level) parallel to Frankfurt horizontal plane.

Results:
Fifty-seven patients and 114 sides (28 class II: 56 sides and 29 class III: 58 sides) were evaluated. Although CT values decreased at most sites of the ramus cortical bone after 1 year of surgery, they increased at the posterior-medial site at the upper level in class II (P=0.0012) and the lower level in class III (P=0.0346).

Conclusion:
This study suggested that bone quality at the mandibular ramus could change after 1 year of surgery, and there could be differences between mandibular advancement and setback surgery.
Anxiety, depression, and insomnia among nurses during the full liberalization of COVID-19: A multicenter cross-sectional analysis of the high-income region in China
Authors: Xiao Julan , Liu Lili , Peng Yueming , Wen Yi , Lv Xia , Liang Lijun , Fan Yi , Chen Jie , Chen Yanru , Hu Hongying , Peng Weisi , Wang Haiyan , Luo Weixiang 
Published: March 2023

AbstractAims and objectivesThis study demonstrates the impact of the full liberalization of COVID-19 on the psychological issues and the prevalence rate and associated factors of depressive symptoms, anxiety, and insomnia among frontline nurses.BackgroundIt has been demonstrated that frontline nurses fighting against the epidemic were under great psychological stress. However, there is a lack of studies assessing the prevalence rates of anxiety, depression, and insomnia among frontline nurses after the full liberalization of COVID-19 in China.DesignCross-sectional study.MethodsOf 1766 frontline nurses were invited to complete a self-reported online questionnaire by convenience sampling. The survey included six main sections: the Patient Health Questionnaire, the Generalized Anxiety Disorder Scale, the Insomnia Severity Index, the Perceived Stress Scale, sociodemographic information, and work information. Multiple logistic regression analyses were applied to identify the potential risk factors for psychological issues. Reporting of this research according to the STROBE checklist.Results90.83% of frontline nurses were infected with COVID-19, and 33.64% had to work while infected COVID-19. The overall prevalence of depressive symptoms, anxiety and insomnia among frontline nurses was 69.20%, 62.51%, and 76.78%, respectively. Multiple logistic analyses revealed that job satisfaction, attitude toward the current pandemic management, and perceived stress were associated with depressive symptoms, anxiety, and insomnia.ConclusionsThis study demonstrated that the full liberalization of COVID-19 had a significant psychological impact on frontline nurses. Early detection of mental health issues and preventive and promotive interventions should be implemented according to the associated factors to improve mental health of nurses.Relevance to clinical practiceThis study highlighted that nurses were suffering from varying degrees of depressive symptoms, anxiety, and insomnia, which needed early screening and preventive and promotive interventions for preventing a more serious psychological impact on frontline nurses.Patient or Public ContributionNo Patient or Public Contribution.
Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor
Authors: Chen Xiaoxin , Huang Xiaodong , Ma Qinhai , Kuzmič Petr , Zhou Biao , Xu Jinxin , Liu Bin , Jiang Haiming , Zhang Wenjie , Yang Chunguang , Wu Shiguan , Huang Jianzhou , Li Haijun , Long Chaofeng , Zhao Xin , Xu Hongrui , Sheng Yanan , Guo Yaoting , Niu Chuanying , Xue Lu , Xu Yong , Liu Jinsong , Zhang Tianyu , Spencer James , Deng Wenbin , Chen Shu-Hui , Xiong Xiaoli , Yang Zifeng , Zhong Nanshan 
Published: March 2023

AbstractSARS-CoV-2 has demonstrated extraordinary ability to evade antibody immunity by antigenic drift. Small molecule drugs may provide effective therapy while being part of a solution to circumvent SARS-CoV-2 immune escape. In this study we report an α-ketoamide based peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro), RAY1216. Enzyme inhibition kinetic analysis established that RAY1216 is a slow-tight inhibitor with aKi of 8.6 nM; RAY1216 has a drug-target residence time of 104 min compared to 9 min of PF-07321332 (nirmatrelvir), the antiviral component in Paxlovid, suggesting that RAY1216 is approximately 12 times slower to dissociate from the protease-inhibitor complex compared to PF-07321332. Crystal structure of SARS-CoV-2 Mpro:RAY1216 complex demonstrates that RAY1216 is covalently attached to the catalytic Cys145 through the α-ketoamide warhead; more extensive interactions are identified between bound RAY1216 and Mproactive site compared to PF-07321332, consistent with a more stable acyl-enzyme inhibition complex for RAY1216. In cell culture and human ACE2 transgenic mouse models, RAY1216 demonstrates comparable antiviral activities towards different SARS-CoV-2 virus variants compared to PF-07321332. Improvement in pharmacokinetics has been observed for RAY1216 over PF-07321332 in various animal models, which may allow RAY1216 to be used without ritonavir. RAY1216 is currently undergoing phase III clinical trials (https://clinicaltrials.gov/ct2/show/NCT05620160) to test real-world therapeutic efficacy against COVID-19.
FAN, the homolog of mammalian Apoptosis Antagonizing Transcription Factor AATF/Che-1 protein, is involved in safeguarding genome stability through the ATR induced pathway inArabidopsis
Authors: Liu Fang , Wang Bingshan , Wang Xiangyang , Dong Daofeng , De Veylder Lieven , Qi Shengdong , Horvath Beatrix M. , Palme Klaus , Li Xugang 
Published: March 2023

ABSTRACTCellular DNA can be damaged by endogenous or exogenous genotoxins. In plants, reduced genome stability can have a detrimental effect on development. Here, we show the identification of thefanmutant from an ethyl-methanesulfonate (EMS) mutagenizedArabidopsisCol-0 population on the basis of its short root and small leaf phenotype. The causative mutation was identified as a G-to-A transition at the border of the eighth intron and ninth exon of theAt5G61330gene, resulting in a mis-spliced mRNA transcript. FAN is a homolog of the mammalian AATF/Che-1 protein consisting of conserved AATF/Che-1 and TRAUB domains inArabidopsis. In thefanmutant, under normal conditions, we detected DNA damage and cell death response at the root tip, while hypersensitivity to the exogenously applied hydroxyurea (HU) compared to Col-0, suggesting that FAN plays a role in the DNA damage response (DDR). Furthermore, our results showed that FAN is involved in DDR pathway regulated by ATM/RAD53-RELATED (ATR). Taken together, these suggest that FAN is required for meristem maintenance and the DNA damage response.
The Drug Repurposing Encyclopedia (DRE): a web server for systematic drug repurposing across 20 organisms
Authors: Li Xuexin , Pan Lu , Sanchez-Burgos Laura , Hühn Daniela , Fernandez-Capetillo Oscar 
Published: March 2023

ABSTRACTThe identification of new therapeutic uses for compounds via computational or experimental approaches, which is widely known as drug repurposing, has the potential to develop novel therapies with pre-existing medicines, thereby reducing the time and costs associated with drug development. Today, several data-driven methodologies have been developed leading to databases that facilitate drug repurposing initiatives. However, no approach has systematically compared drug transcriptional profiles to those from a wide spectrum of human diseases or molecular pathways. Here, we present the Drug Repurposing Encyclopedia (DRE,https://www.drugrep.org), an interactive web server covering over 198M significant drug-signature associations across 20 organisms to allow users to carry out drug-repositioning analyses. DRE consists of 12 modules covering real-time drug-repurposing for user-provided transcriptional signatures; gene set enrichment analysis (GSEA) for all available drug transcriptomics profiles; as well as similarity analyses for provided gene sets across all database signatures. Collectively, DRE provides a one-stop comprehensive solution to help scientists interested in drug-repurposing studies.
Correlating physicochemical and biological properties to define critical quality attributes of a recombinant AAV vaccine candidate
Authors: Kumar Prashant , Wang Michael , Kumru Ozan S. , Hickey John , Sanmiguel Julio , Zabaleta Nerea , Vandenberghe Luk H. , Joshi Sangeeta B. , Volkin David B. 
Published: March 2023

AbstractRecombinant adeno-associated viruses (rAAVs) are a preferred vector system in clinical gene transfer. A fundamental challenge to formulate and deliver rAAVs as stable and efficacious vaccines is to elucidate interrelationships between the vector’s physicochemical properties and biological potency. To this end, we evaluated an rAAV-based COVID-19 vaccine candidate which encodes the Spike antigen (AC3) and is produced by an industrially-compatible process. First, state-of-the-art analytical techniques were employed to determine key structural attributes of AC3 including primary and higher-order structures, particle size, empty/full capsid ratios, aggregates and multi-step thermal degradation pathway analysis. Next, several quantitative potency measures for AC3 were implemented and data were correlated with the physicochemical analyses on thermal-stressed and control samples. Results demonstrate links between decreasing AC3 physical stability profiles,in vitrotransduction efficiency in a cell-based assay, and importantly,in vivoimmunogenicity in a mouse model. These findings are discussed in the general context of future development of rAAV-based vaccines candidates as well as specifically for the rAAV vaccine application under study.
ELECTRONIC-BASED HEALTH PROMOTION MODELS ON THE USE OF POST PLACENTAL IUD BIRTH CONTROL: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Sulistiyanto Henri , Soetrisno  , Subiyanto A.A , Setyowati Retno 
Published: March 2023

AbstractLow levels of IUD use, especially post-placental IUDs, are associated with bias and lack of information because contraceptive counseling is limited, for example, through conversations with doctors, written materials, or audiovisual techniques. This study aimed to identify electronic (video) interventions using post-placental IUD contraception through systematic review and meta-analysis. Based on those keywords, some results were obtained: 509 from Google Scholar, 33 from PubMed, 14 from Science Direct, 88 from Sage Journal, 50 from Springer Links, 20 from Scopus, and 178 from ProQuest. In addition, the recording was carried out on the bibliography of review articles, 12 articles were obtained for systematic review, and five meta-analyses were carried out. The heterogeneity test shows a value ρ greater than 0.05, which is ρ =0.88 with I2= 0%, meaning that the variation between studies is homogeneous. The Random Effects Model yielded a pooled odds ratio of 1.07 (95& CI 0.26-4.39). The value ρ = 0.93 so that there was no difference between the treatment and control groups, and the data were homogeneous, an odd ratio of 1.07 was obtained, it was found that video use could increase 1.07 times the knowledge, skills, and decision-making of using post placental IUD compared to those who did not use video.
Neural dynamics in the limbic system during male social behaviors
Authors: Guo Zhichao , Yin Luping , Osakada Takuya , Lischinsky Julieta , Chien Jonathan , Dai Bing , Urtecho Ashley , Tong Xiaoyu , Chen Zhe S. , Lin Dayu 
Published: March 2023

SummarySexual and aggressive behaviors are two evolutionarily conserved social behaviors vital for an animal’s survival and reproductive success. While an increasing number of brain regions in the limbic system have been identified as functionally relevant for these two types of behaviors, an understanding of how social cues are represented across brain regions and how social behaviors are generated via this network activity remains elusive. To gain a holistic view of the neural responses during social behaviors, we utilized multi-fiber photometry to simultaneously record Ca2+signals of estrogen receptor alpha(Esr1)-expressing cells from 13 limbic brain regions in male mice during sexual and aggressive behaviors and compare the response magnitude and temporal patterns across regions. We find that conspecific sensory information, as well as social action initiation signals, are widely distributed in the limbic system and can be decoded from the network activity. Cross-region correlation analysis reveals striking increases in functional connectivity in the network during the action initiation phase of social behaviors whereas advanced copulation is accompanied by a “dissociated” network state. Based on the response patterns, we propose a mating-biased network (MBN) and an aggression-biased network (ABN) for mediating male sexual and aggressive behaviors, respectively.
Modulation of Polar Auxin Transport Identifies the Molecular Determinants of Source-Sink Carbon Relationships and Sink Strength in Poplar
Authors: Balasubramanian Vimal Kumar , Rivas-Ubach Albert , Winkler Tanya , Mitchell Hugh , Moran James , Ahkami Amir H. 
Published: March 2023

AbstractSource-to-sink carbon (C) allocation driven by the sink strength, i.e., the ability of a sink organ to import C, plays a central role in tissue growth and biomass productivity. However, molecular drivers of sink strength have not been thoroughly characterized in trees. Auxin, as a major plant phytohormone, regulates the mobilization of photoassimilates in source tissues and elevates the translocation of carbohydrates toward sink organs, including roots. In this study, we used an ‘auxin-stimulated carbon sink’ approach to understand the molecular processes involved in the long-distance source-sink C allocation in poplar. Poplar cuttings were foliar sprayed with polar auxin transport modulators, including auxin enhancers (AE) (i.e., IBA and IAA) and auxin inhibitor (AI) (i.e., NPA), followed by a comprehensive analysis of leaf, stem, and root tissues using biomass evaluation, phenotyping, C isotope labeling, metabolomics, and transcriptomics approaches. Auxin modulators altered root dry weight and branching pattern, and AE increased photosynthetically fixed C allocation from leaf to root tissues. The transcriptome analysis identified highly expressed genes in root tissue under AE condition including transcripts encoding polygalacturonase and β-amylase that could increase the sink size and activity. Metabolic analyses showed a shift in overall metabolism including an altered relative abundance levels of galactinol, and an opposite trend in citrate levels in root tissue under AE and AI conditions. In conclusion, we postulate a model suggesting that the source-sink C relationships in poplar could be fueled by mobile sugar alcohols, starch metabolism-derived sugars, and TCA-cycle intermediates as key molecular drivers of sink strength.
A discussion of “information processing costs and firm-specific information flows: evidence from the launch of high-speed railway in China”
Authors: Zhu Haoran 
Published: March 2023

PurposeThis paper aims to discuss the strengths and limitations of Zhao et al. (2022). The author also provides suggestions for future research.Design/methodology/approachThe author initially reviews prior literature studies relevant to this study, i.e. the literature on the relation between geographic proximity and information transfer/acquisition, to better position this paper in existing literature and then briefly discusses the strengths and weaknesses of this paper to provide more insights. Finally, the author presents some possible directions for future research, highlighting the importance of separately examining headquarters and plants in this research setting, and motivating future research on the development of information technology.
Going all the way? LGBTQ people’s receptiveness to gay-themed advertising in a Belgian context
Authors: Demunter Rein , Bauwens Joke 
Published: March 2023

Purpose
Through investigating how Belgian LGBTQ people evaluate gay-themed print and television advertising in mainstream media, the purpose of this study is to explore how gay-themed advertising strategies are evaluated in relation to context.

Design/methodology/approach
Qualitative in-depth interviews were conducted with 17 Flemish self-identified lesbian, gay male and bisexual people.

Findings
Findings of this research demonstrate the importance of the situated context in which LGBTQ people receive and evaluate gay-themed advertisements. By offering a common stock of social knowledge and experience, context creates a framework against which LGBTQ people evaluate gay-themed advertisements. In this specific research that was conducted in a Western-European LGBTQ-friendly society (Belgium), critical evaluations of gay-washing and the dirty laundry effect were found. The positive evaluations of explicit gay-themed and inclusive advertisements also highlighted the importance of advertising an inclusive society.

Research limitations/implications
In considering how gay-themed advertising evaluations relate to context and lived experiences, this research contributes to current knowledge on gay-themed advertising and its reception within LGBTQ groups.

Practical implications
This research offers valuable insights to marketers on how to target sexual minorities in LGBTQ (un)friendly societies.

Social implications
Findings highlight the social importance of minority-oriented advertising. Not only can such advertising promote civic inclusion and social recognition of minority groups, it also has the potential to play a key role in the construction and normalisation of identities.

Originality/value
In an effort to reinvigorate current marketing debates on gay-themed advertising, this study builds on theoretical insights gained via reception research and LGBTQ studies. In doing so, this research yields a more nuanced and contextualised understanding of LGBTQ people’s engagement with various gay-themed advertisements. Considering within a Western European society the relevance of context when researching gay-themed advertisement reception, the results add to primarily US-based research on this topic.
How far is municipal transparency from neighbours? Evidence from Spain and Portugal
Authors: Tejedo-Romero Francisca , Rodrigues Miguel , Araujo Joaquim Filipe Ferraz Esteves 
Published: March 2023

PurposeThis manuscript studies municipal transparency in Iberian countries, Spain and Portugal, to analyse similarities and differences in both countries. Despite some political-administrative similarities, the way Spain and Portugal, deal with the issue of transparency may vary.Design/methodology/approachBased on the levels of municipal transparency, this work aims to analyse how legal and institutional context and political factors framed the way municipalities are managing the “naming and shaming” approach resulting from the creation of the Municipal Transparency Index. A descriptive analysis of the levels of municipal transparency will be carried out and a multivariate analysis to study the characteristics that may be determining differences and similarities between the two countries.FindingsThe study shows similarities in municipal transparency in Iberian countries, the positive effect of the “naming and shaming” approach on transparency and the influence of legal and institutional factors in transparency.Originality/valueWhile there is extensive attention to municipal transparency at the country level, less research focuses on comparing municipal transparency in countries that have similar political-administrative characteristics. This study addresses this research gap by investigating two neighbouring countries.
Effect of compound pit textures on the friction and wear of thrust cylindrical roller bearings under starved lubrication
Authors: Wang Yueyong , Zhang Yimin , Long Risheng 
Published: March 2023

Purpose
This study aims to investigate the effect of compound pit textures on the tribological properties of thrust cylindrical roller bearings (TCRBs) using several parameters, such as compound type, pit diameter, pit depth and pit area density.

Design/methodology/approach
The surface texture parameters of the shaft washer (WS) raceway include pit diameter (D; 100, 300 and 500 µm), pit depth (H; 10 and 20 µm) and pit area density (S; 10%, 13% and 18%). Pits were produced on the WS of the TCRBs using laser marking equipment. The friction and wear performances of compound pit-textured TCRBs under starved lubrication conditions are studied using a friction and wear test rig. The influence mechanisms of the compound pit texture on the friction and wear properties of TCRBs are discussed through real tests and discussions.

Findings
Compared with nontextured bearings, the average coefficient of friction (ACOFs) and wear loss of TCRBs with single/compound pit textures are reduced when rotating under starved lubrication. D has the greatest effect on the COFs curve. When D = 300 µm, H = 10 µm and S = 10%, the ACOF and wear loss are the lowest, that is, 0.0207 and 3.38 mg, respectively. Under the same lubrication conditions, compared with the nontextured bearing group, the COF and wear loss are reduced by 41.4 and 59.6%, respectively.

Originality/value
This study provides a useful reference for the raceways of textured TCRBs.