bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case study of the use of the Matlab/Simulink tool in the management of coal combustion in Brazil's emission standards
Authors: Brandão Yago Fraga Ferreira , Santos Valdemir Alexandre dos 
Published: April 2023

Abstract
Combustion is a chemical reaction that occurs when fuel elements react with air, resulting in a large amount of heat emitting polluting gases. In thermoelectric plants, the energy used results from burning fossil fuels such as coal, oil, or gas. Aiming at better environmental conditions and improvement in the use of fuel, we studied technical data on the composition of coal and technical data on combustion, such as reactions and factors that can influence the process. Were performed the mass and energy balances of the process. We used the emission levels for stationary sources, established by CONAMA (National Council for the Environment) to understand which gases are most harmful to the air. It was used as a database of the literature, establishing a tolerance of 5% for maximum deviations from valid results. After validation, the graphics of the SIMULINK/MATLAB tool were used for a visual response of the levels obtained in the analysis and the limits of CONAMA. The results obtained were within the tolerance, being considered acceptable, explaining the possible variations, also presenting a small amount of polluting gases observing the results of the gases that because more damage to the environment. Compared with the experimental results, the model elaborated on the developed algorithm was validated, and its graphic results showed a considerable difference between the analyzed sample and the limits established by CONAMA (above the limits), being able to be used to create a combustion management program.
Arginine and its metabolites stimulate proliferation, differentiation, and physiological function of porcine trophoblast cells
Authors: Li Shuai , Ye Xiangyang , Wen Xiaolu , Yang Xuefen , Wang Li , Xiao Hao , Gao Kaiguo , Jiang Zongyong 
Published: April 2023

Abstract

Arginine, which is metabolized into ornithine, proline, and nitric oxide, plays an important role in embryonic development. The present study was conducted to investigate the molecular mechanism of arginine in proliferation, differentiation, and physiological function of porcine trophoblast cells (pTr2) through metabolic pathways. The results showed that arginine significantly increased cell viability (P<0.05). The addition of arginine had a quadratic tendency to increase the content of progesterone (P=0.06) and protein synthesis rate (P=0.03), in which the maximum protein synthesis rate was observed at 0.4 mM arginine. Arginine quadratically increased (P<0.05) the intracellular contents of spermine, spermidine and putrescine, as well as linearly increased (P<0.05) the intracellular content of NO in a dose-dependent manner. Arginine showed a quadratic tendency to increase the content of putrescine (P=0.07) and a linear tendency to increase NO content (P=0.09) in cell supernatant. Moreover, increasing arginine activated (P<0.05) the mRNA expressions for ARG, ODC, iNOS and PCNA. Furthermore, inhibitors of arginine metabolism (L-NMMA and DFMO) both inhibited cell proliferation, while addition of its metabolites (NO and putrescine) promoted the cell proliferation and cell cycle, the mRNA expressions of PCNA, EGF and IGF-I, and increased (P<0.05) cellular protein synthesis rate, as well as estradiol and hCG secretion (P<0.05).
Boundary corrections on multi-dimensional PDEs
Authors: González-Pinto S. , Hernández-Abreu D. , Pérez-Rodríguez S. 
Published: April 2023

Abstract
Two new boundary correction techniques are proposed in order to mitigate the order reduction phenomenon associated to the numerical solution of initial boundary value problems for parabolic Partial Differential Equations in arbitrary spatial dimensions with time dependent Dirichlet boundary conditions. The new techniques are based on the idea of discretizing the PDE problem at the boundary points as similarly as possible as for the interior points of the domain. These new techniques are considered for the time integration with W-methods based on Approximate Matrix Factorization. By suitably modifying the internal stages of the methods on the boundary points, it is illustrated by numerical testing with time dependent boundary conditions that the new boundary correction techniques are able to keep the same accuracy and order of convergence that the method reaches in the case of homogeneous boundary conditions.
Exploring the Pharmacological Mechanisms of Ginkgo biloba Extract in the Treatment of Sensorineural Hearing Loss
Authors: Li Guangjin , Qiu Jingjing , Wang Chen , Cui Limei , Wang Junxin , Chen Liang , Song Xicheng , Yang Yujuan , Sun Yan 
Published: April 2023

AbstractBackgrounds:Anincreasing people are suffering from sensorineural hearing loss (SNHL) and facing great psychological and physical stress. Although the extract of extract of Ginkgo biloba (EGb) has been widely used to treat SNHL for many years, underlying pharmacological mechanisms remain unclear.Methods:Active ingredients of EGb and compounds targets were retrieved from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). SNHL-related genes were obtained from GeneCards. Venny 2.1 was used to select common targets between active ingredients of EGb and SNHL, and Gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Cytoscape was used to construct a network map to assess the relationship between active ingredients, interacting targets, and signaling pathways, and Chem3D, AutoDock Tools, and PyMol were employed to perform molecular docking between active ingredients and hub genes. Besides, House Ear Institute-Organ of Corti 1 (HEI-OC1) cells were treated with cisplatin and EGb to verify target genes by quantitative Real-time PCR (q-PCR).Results:Venny diagram showing that SNHL and EGb had a total of 64 intersecting targets (core targets). The results of GO and KEGG analysis indicated that 64 core targets were involved in regulating of biological process, stabilization of cell membranes and organelles, protein binding, and diverse signaling pathways. According to the cytoscape and PPI network analyses, three genes (GSK3B, NOS3 and AKT1) and nine kinds of corresponding ingredients (kaempferol, quercetin, sesamin, luteolin, isorhamnetin, isogoycyrol, laricitrin, syringetin and chryseriol) were picked. Molecular docking demonstrates protein binding models for intersection genes and effective ingredients. Eventually, the results of q-PCR experiments further revealed that GSK3B, NOS3 and AKT1 genes exerted their functions in treatment of SNHL by EGb.Conclusions:Our findings indicate the mechanisms of action of EGb in treating SNHL. There are five active components, including luteolin, quercetin, isorhamnetin, kaempferol, and sesamin. Those ingredients exert their effects through regulating three genes (GSK3B, NOS3 and AKT1), which are involved in the PI3K-Akt signaling pathway.
Awareness and Utilization of Smoking Cessation Clinics in Saudi Arabia, Findings from the 2019 Global Adult Tobacco Survey
Authors: Monshi Sarah S. , Alanazi Abdullah M. M. , Alzahrani Ali M. , Alzhrani Abdulrhman A. , Arbaein Turky J. , Alharbi Khulud K. , Alqahtani Mansour Z. , Elkhobby Ahmed A. , Almazrou Aljoharah M. , Al-Zalabani Abdulmohsen H. , Alzahrani Ali. H 
Published: April 2023

Abstract
Background
Tobacco use remains a leading cause of premature death. To combat tobacco use, the Ministry of Health (MOH) improved access to smoking cessation clinics (SCCs) by developing fixed SCCs and mobile SCCs, which move based on demand across locations. The goal of this study was to investigate awareness and utilization of SCCs among tobacco users in Saudi Arabia and the factors that influence their awareness and utilization.
Method
This cross-sectional study used the 2019 Global Adult Tobacco Survey. Three outcome variables were employed, including tobacco users’ awareness of fixed SCCs, mobile SCCs, and utilization of fixed SCCs. Several independent variables were examined, including sociodemographic characteristics and tobacco use. Multivariable logistic regression analyses were performed.
Results
1,667 tobacco users were included in this study. There were 60%, 26%, and 9% of tobacco users who were aware of fixed SCCs, aware of mobile SCCs, and visited fixed SCCs, respectively. The likelihood of being aware of SCCs increased among users residing in urban areas (fixed SCCs: OR = 1.88; 95% CI = 1.31–2.68; mobile SCCs: OR = 2.09; CI = 1.37–3.17) while it decreased among those reported self-employed (fixed SCCs: OR = 0.31; CI = 0.17–0.56; mobile SCCs: OR = 0.42; CI = 0.20–0.89). The likelihood of visiting fixed SCCs increased among educated tobacco users aged 25–34 (OR = 5.61; CI = 1.73–18.21) and 35–44 (OR = 4.22; CI = 1.07–16.64) while the odds of visiting SCCs decreased among those who were working in the private sector (OR = 0.26; CI = 0.09–0.73).
Conclusion
The decision to quit smoking must be supported by an effective healthcare system that provides accessible and affordable smoking cessation services. Knowing the factors that influence the awareness and utilization of SCCs would help policymakers dedicate efforts targeting those who desire to quit smoking yet face limitations in using SCCs.
Evaluation of short-term clinical and imaging outcomes of porous coated trabecular titanium cup manufactured with electron beam melting technique in primary total hip arthroplasty: prospective study of 236 cases
Authors: CHEN Guo , WANG Yicheng , YI Linhong , MA Zou , BI Mengna , LI Zhong , HAN Jie , LU Lisha , ZHANG Shangshang , SHEN Hai , ZHANG Huiwu , ZENG Fanwei , ZHANG Peng , SI Yan 
Published: April 2023

Abstract
Background
The previous acetabular surface manufacturing technology provides a suitable surface for bone ingrowth into cementless cups, but there were already some literatures reporting failure cases due to sintered titanium beads and titanium fiber mesh. Electron beam melting (EBM) technology has been used in manufacturing trabecular titanium acetabular cups with high porosity, pore size suitable for bone ingrowth, low elastic modulus and high friction coefficient. Objectives We study and evaluate the clinical and imaging outcomes of porous coated trabecular titanium cup manufactured with electron beam melting technique with a relatively large sample, in order to provide evidence-based basis for its clinical application.
Methods
Two hundred and thirty-six patients who underwent primary total hip arthroplasty using porous coated trabecular titanium cup from January 2019 to June 2021 in the Department of Joint Surgery of our hospital were selected. General date, imaging information, functional scores and complications were collected to evaluate the early clinical efficacy of the cup.
Results
All patients were followed up for 17–46 months, with an average of (26.2 ± 9.2) months. At the last follow-up, the preoperative HSS score increased from 43.7 ± 6.8 to 85.6 ± 9.3 points with statistical significance (P < 0.01). The preoperative WOMAC score improved from 59.2 ± 5.8 to13.1 ± 3.5 points, with statistical significance(P < 0.01). 92.3% of patients were satisfied or very satisfied with the clinical outcome. The cup survival rate at the last follow-up was 100%.
Conclusions
It can provide patients with satisfactory short-term clinical and imaging results in primary total hip arthroplasty to use porous coated trabecular titanium cup manufactured by electron beam melting technology based on structural optimization design. The acetabular cup has good initial stability, a high survival rate and good bone ingrowth, which can significantly improve the pain and function of the affected hip.
Petrographic and geochemical analyses of Late Bronze and Iron Age pottery assemblages from Arslantepe (Malatya, Türkiye): Insights into the local organization of the production and extra- regional networks of exchange
Authors: Fragnoli Pamela , Manuelli Federico 
Published: April 2023

Abstract
In this paper we analyzed Late Bronze and Iron Age pottery assemblages from the site of Arslantepe (Malatya, eastern Türkiye) by combining thin-section petrography and X-ray wavelength dispersive fluorescence. Following an introduction to the site and an overview of the archaeological and historical evidence, the analysis is presented, and the outcomes discussed in the wider framework of the Syro-Anatolian and eastern Mediterranean regions. The results show elements of both continuity and change over the 2nd millennium and until the beginning of the 1st millennium BC. On a local level, the use of volcanic-based recipes for the production of painted vessels represents the most striking element of continuity. In contrast, noteworthy elements of changes relate to an increased exploitation of southern deposits for material supply and the standardization of paste recipes for cooking pots. Remarkable results also pertain to extra-regional exchanges: The Late Bronze Age Red-Lustrous Wheel-made Ware found at the site is imported from Cilicia, while the wares of foreign tradition from the Middle Iron Age levels are mostly locally produced.
Reproductive Studies on Paphia textile - Paratapes textilis - (Gmelin 1971): An Indicator of Aquaculture Management along the Egyptian waters of the Red Sea and Suez Canal
Authors: Farghaly Marwa , Ali Tamer El-Sayed , Mitwally Hanan M. , Razekb Fatma A. Abdel 
Published: April 2023

Abstract
Understanding the reproductive biology of aquatic biota is essential for better management and sustainability of coastal ecosystems and aquaculture development. The bivalve Paphia textile (Gmelin 1971) also known as Paratapes textilis, has an economic value in Indo-Pacific waters and the Red Sea. P. textile suffers from extensive fishing and exploitation. The current work aims to study the reproductive cycle of P. textile for the first time in the Egyptian waters of the Red Sea. Samples were collected monthly from two saline lakes at the Suze Gulf from December 2019 to November 2020. As part of the comprehensive research study, sex ratio, condition index, sexuality, histological analysis of the gonad maturity stages, shell size at maturity, and gonad index, were used to investigate the reproductive cycle. The results revealed that the sex ratio was male biased possibly due to anthropogenic stressors. Paphia textile has dioecious sexuality and hermaphroditism is lacking. The condition index in winter and spring indicates periods dominated by mature individuals. Five reproductive maturity stages were assigned for P. textile males and females. The prevailing warm water year-round could be the reason behind the lack of successive stages of gonad maturity and periodicity. The study indicates that gonad development is a function of temperature, salinity, and chlorophyll. The Paphia textile shell sizes at which 50% of the population reached maturity ranged between 28 mm and 34 mm for females and males, respectively. A gonad index indicates the ripe stages. Study findings suggest the most suitable temperature for aquaculture spawning is between 20 ◦C and 30 ◦C in subtropical waters, and fishing should be prohibited at sizes less than 28.60 mm in general for males and females for better management and sustainability of this aquatic resource.
Feather’s composition of South polar skua (Stercorarius maccormicki) using WDXRF
Authors: Bighetti G. P. , Souza R. C. , Carvalho H. R. A. , Silva C. C. , Torres J. P. M. 
Published: April 2023

Abstract
This study investigated the feathers’ composition of South polar skua (Stercorarius maccormicki) using WDXRF, evaluating the concentration of essential and non-essential elements in the feathers, and dividing it into rachis and barb parts. We collected South polar skuas feathers from Hennequin Point, King George Island, South Shetland, Antarctic Peninsula in January of 2013. Our results show that 18 elements were observed in the composition of the feathers, with a different concentration between the rachis and barbs, qualitatively and quantitatively. Only 3 elements observed were classified as non-essentials but still mostly elements do not have a function described in the literature to the feathers. According to our knowledge, this is the first study that uses this technique to evaluate the concentration of different elements in the feathers. The findings of this study highlight the use of alternative techniques to biomonitoring elements in the ecosystem and bring baseline information for future studies.
Relocation and Stress Analysis of the 2018 Mandali-Sumar Earthquake Sequence, Iraq-Iran Border
Authors: Al-Kaabi Muntadher , Hantoosh Dania , Abdulnaby Wathiq 
Published: April 2023

Abstract
The 2018 Mandali-Sumar earthquake sequence has started in January 2018 at the Iraq-Iran border within the Low Folded Zone of the Zagros Fold-Thrust Belt. To study the fault that is responsible for this earthquake sequence, the relocation of 32 earthquakes was conducted. In addition, moment tensor solutions of 9 large earthquakes were collected to know the fault motion and stress regime in the study area. The Computer Programs in Seismology (CPS) was used to analyze waveform data taken from 33 seismic stations located in Iraq and Iran to relocate earthquakes. The location of the earthquake sequence based on the IRSC bulletin shows a scattered spatial distribution, but the results of the relocations show that the earthquakes of the sequences are aligned in a longitudinal feature parallel to an anticline limb located in Ilam and Kermanshah provinces near the Iraqi border. The moment tensor solutions indicate that the sequence is related to a thrust fault with a 342º strike direction, 35º NE dip angle, and 76º rake angle. The TENSOR program was used to perform formal stress inversion of moment stress axes, which revealed that the azimuth of the maximum horizontal stress axis is 63º. The epicenters of the sequence are located between the Mountain Front Fault to the NE and the Zagros Foredeep Fault to the Southeast. We believe that the 2018 Mandali-Sumar earthquake sequence is related to displacement on the surface of the Zagros Foredeep Fault within the uppermost basement and the lowermost Phanerozoic cover.
A study on the design of a fitness furniture and its Finite element analysis
Authors: Guo Wenlong , He Jiarong , Li Kezhong , Zhang Jijuan , Zhang Zhongfeng 
Published: April 2023

Abstract
Objectives. To explore the demand for fitness furniture and the feasibility of its fitness function in the context of the current adaptation of home fitness equipment to the home environment.
Methods. Taking the growing demand for home fitness as the background, the problems of current home fitness equipment and home environment are analysed, the design path of fitness furniture is explored, and the fitness armchair is used as an example for design practice and Finite element analysis (FEA) simulation verification.
Results. The design is based on the human movement during fitness, the user's usage and emotional needs and the characteristics of the home environment and domestic space, as well as a combination of design factors such as shape, functionality, safety, versatility and ergonomics. We have designed fitness furniture that meets the needs of fitness and fits into the home environment.
Conclusion. The design of home fitness furniture must take into account the unity between the user, the fitness furniture and the home environment in order to facilitate comfortable and safe fitness activities in the home and to create a harmonious home environment.
High intensity exercise preconditioning influences on steroid hormones following the experimental autoimmune encephalomyelitis model
Authors: Nourshahi Maryam , Mirghaisari Maryam , Talebi-Garakani Elahe , Soleimani Maryam , Alvandi Masomeh , Farahmand Fattaneh 
Published: April 2023

Abstract
Steroid hormones improve clinical and pathological symptoms using the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). In addition, exercise seems to play an important role in increasing hormones such as 17beta-estradiol and estrogen receptor beta (ERβ). In the present study, we evaluated whether 6 weeks of high-intensity interval training (HIIT) prior to induction of EAE increased 17beta-estradiol and ERβ and attenuate the severity of symptoms and/or disease progression in the EAE model. Female C57BL/6 mice were randomly divided into exercise (EX) and control (Con) groups. After 4 weeks of training, EAE was induced in half of the Con and the EX groups. The EAE-EX group after EAE induction trained for two more weeks. The EX group trained for 6 weeks. Six weeks of HIIT increased 17beta-estradiol and ERβ in the EX group compared to the control group (P ≤ 0.05). The EAE-EX group had a significant increase in 17beta-estradiol and ERβ and a significant decrease in clinical symptoms compared to the EAE group (P ≤ 0.05). In addition, the EAE group had a significant decrease in ERβ (P ≤ 0.05) compared to the control group. Our data demonstrate that 6 week of HIIT increased 17beta-estradiol and ERβ in the cerebellum tissue. These hormones are associated with decrease clinical outcomes and further research is required to examine potential clinical relevance.
Ophthalmic Findings in Patients with Autosomal Recessive Lamellar Ichthyosis due to TGM1 Mutations in an Isolated Population
Authors: Macriz-Romero Nicole , Vera-Duarte Guillermo Raúl , Guerrero-Becerril Jesús , Chacón-Camacho Oscar F. , Astiazarán-Osornio Mirena , Zenteno Juan Carlos , Graue-Hernández Enrique O. 
Published: April 2023

Abstract
Purpose: To describe the ocular clinical characteristics of a group of Mexican patients with lamellar ichthyosis (LI) arising from TGM1 pathogenic variants.
Methods: Ophthalmological exploration, pedigree analysis and genetic screening were performed in patients with an established clinical diagnosis of lamellar ichthyosis from families located in a small community in the Southeast of Mexico.
Results: Nine patients with LI in five families were identified. There were 6 affected females. All patients (9/9) demonstrated eye lid abnormalities with eight patients showing lid margin abnormalities. Madarosis was present in only 3 individuals and corneal scarring was documented in 2. All 9 individuals carried biallelic TGM1 variants, either homozygously or as compound heterozygous.
Conclusion: Ocular anomalies are common in individuals with TGM1-related LI. The occurrence of a variety of private or rare mutations hampers the identification of a genotype-phenotype correlation for ocular anomalies in this disorder.