bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Model to Estimate the Optimal Number of Oocytes to Attempt to Fertilize During Assisted Reproductive Technology Treatment
Authors: Correia Katharine F. B. , Missmer Stacey A. , Weinerman Rachel , Ginsburg Elizabeth S. , Rossi Brooke V. 
Published: January 2023

ImportanceSurplus cryopreserved embryos pose a challenge for in vitro fertilization patients and clinics; with Roe v. Wade overturned, some states may deem the discarding of surplus embryos illegal, radically changing in vitro fertilization practice. An evidence-based tool would help limit surplus embryo creation.ObjectiveTo develop a prediction tool for determining how many oocytes should be exposed to sperm to create embryos to conserve the chance of live birth while minimizing surplus embryos.Design, Setting, and ParticipantsThis diagnostic study used data from member clinics of the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System between 2014 to 2019. A total of 410 719 oocyte retrievals and 460 577 embryo transfer cycles from 311 237 patients aged 18 to 45 years old who initiated their first oocyte stimulation cycle between January 1, 2014, and December 31, 2019, were included. Data were analyzed from February to June 2022.ExposuresFemale patient age, anti-mullerian hormone level, diminished ovarian reserve diagnosis, number of oocytes retrieved, and the state where the clinic is located were included in the final models.Main Outcomes and MeasuresThe algorithm was based on 3 models with outcomes: (1) day of transfer; (2) proportion of retrieved oocytes that become usable blastocysts; and (3) number of blastocysts needed for transfer for 1 live birth to occur.ResultsThe median (IQR) age at stimulation cycle start was 35 (29-32) years and the median (IQR) number of oocytes retrieved was 10 (6-17). The likelihood of recommending that all oocytes be exposed to sperm increased with age; less than 20.0% of retrievals among patients younger than 32 years and more than 99.0% of retrievals among patients older than 42 years received recommendations that all oocytes be exposed to sperm. Among cycles recommended to expose fewer than all oocytes, the median (IQR) numbers recommended for 1 live birth were 7 oocytes (7-8) for patients aged less than 32 years, 8 (7-8) for patients aged 32 to 34 years, and 9 (9-11) for patients aged 35 to 37 years.Conclusions and RelevanceIn this diagnostic study of in vitro fertilization cycles, a prediction tool was developed to aid clinicians in determining the optimal number of oocytes to expose to sperm, reducing the number of unused embryos created and immediately addressing current patient and clinician concerns.
Evaluation of treatment planning system accuracy in estimating the stopping‐power ratio of immobilization devices for proton therapy
Authors: Jiang Kai , MacFarlane Michael , Mossahebi Sina , Zakhary Mark J. 
Published: January 2023

AbstractPurposeTo assess treatment planning system (TPS) accuracy in estimating the stopping‐power ratio (SPR) of immobilization devices commonly used in proton therapy and to evaluate the dosimetric effect of SPR estimation error for a set of clinical treatment plans.MethodsComputed tomography scans of selected clinical immobilization devices were acquired. Then, the water‐equivalent thickness (WET) and SPR values of these devices based on the scans were estimated in a commercial TPS. The reference SPR of each device was measured using a multilayer ion chamber (MLIC), and the differences between measured and TPS‐estimated SPRs were calculated. These findings were utilized to calculate corrected dose distributions of 15 clinical proton plans for three treatment sites: extremity, abdomen, and head‐and‐neck. The original and corrected dose distributions were compared using a set of target and organs‐at‐risk (OARs) dose–volume histogram (DVH) parameters.ResultsOn average, the TPS‐estimated SPR was 19.5% lower (range, −35.1% to 0.2%) than the MLIC‐measured SPR. Due to the relatively low density of most immobilization devices used, the WET error was typically <1 mm, but up to 2.2 mm in certain devices. Overriding the SPR of the immobilization devices to the measured values did not result in significant changes in the DVH metrics of targets and most OARs. However, some critical OARs showed noticeable changes of up to 6.7% in maximum dose.ConclusionsThe TPS tends to underestimate the SPR of selected proton immobilization devices by an average of about 20%, but this does not induce major WET errors because of the low density of the devices. The dosimetric effect of this SPR error was negligible for most treatment sites, although the maximum dose of a few OARs exhibited noticeable variations.
Pertopia: Speculative Thinking in a Short‐Term World
Authors: Karakiewicz Justyna 
Published: January 2023

AbstractIn the face of climate change and human equity, architects are still presenting pristine images of perfect urban plans stuck in the aspic of a bygone age that has precipitated the difficult global condition we find ourselves in. Here Justyna Karakiewicz – Professor of Architecture and Urban Design in the Faculty of Architecture, Building and Planning at the University of Melbourne – describes some of the conceptual and practical notions explored at her home university to ameliorate this.
An Urban Odyssey: City Beautiful to City Instagrammable
Authors: Oliveras Jordi 
Published: January 2023

AbstractProfessor at the Polytechnic University of Catalonia Jordi Oliveras describes the centuries‐long history of ‘beautifying the city’. He discusses how utopian ideas of urban form and placement or architectural design can quickly become dystopian by blindly following rules of classical symmetry or ideas of modernist fashion.
Arcological City: Going Underground
Authors: Burry Jane , Latifi Mehrnoush 
Published: January 2023

AbstractIt is clear that we must redesign our domestic and urban environment to mitigate our present climate problems. To that end, it is necessary to look at historic tactics of shelter and climate mitigation but equally plan for the deeper future. This might entail spending more time under ground. Mehrnoush Latifi is a lecturer, researcher and the course director of the Bachelor of Design (Architecture) at Swinburne University of Technology in Melbourne. She and Guest‐Editor Jane Burry here explore the potential of life below the earth's surface.
The City of Frictionless Mobility
Authors: Woodcock Ian 
Published: January 2023

Abstract'Frictionless mobility’, such as through driverless vehicles, has of course been a goal for a very long time in the minds of engineers and designers. But what type of contemporary city might evolve from this? And what happens to other, perhaps more sustainable modes of transport in its wake? Ian Woodcock, Senior Lecturer in Urbanism at the School of Architecture, Design and Planning at the University of Sydney, and Adjunct Associate Professor at the Centre for Design Innovation, Swinburne University of Technology, Melbourne, explores these questions and speculates about the city of the future.
Advances in the Production of Olfactory Receptors for Industrial Use
Authors: Cho Seongyeon , Park Tai Hyun 
Published: January 2023

AbstractIn biological olfactory systems, olfactory receptors (ORs) can recognize and discriminate between thousands of volatile organic compounds with very high sensitivity and specificity. The superior properties of ORs have led to the development of OR‐based biosensors that have shown promising potential in many applications over the past two decades. In particular, newly designed technologies in gene synthesis, protein expression, solubilization, purification, and membrane mimetics for membrane proteins have greatly opened up the previously inaccessible industrial potential of ORs. In this review, gene design, expression and solubilization strategies, and purification and reconstitution methods available for modern industrial applications are examined, with a focus on ORs. The limitations of current OR production technology are also estimated, and future directions for further progress are suggested.
Gradient Bandgap‐Tunable Perovskite Microwire Arrays toward Flexible Color‐Cognitive Devices
Authors: Fu Yue , Yuan Meng , Zhao Yingjie , Dong Meiqiu , Guo Yangwu , Wang Kui , Jin Chunqi , Feng Jiangang , Wu Yuchen , Jiang Lei 
Published: January 2023

AbstractColor‐cognitive detection plays an important role in many developing applications such as optical sensing, high‐solution imaging, wearable biometric monitoring, and human visual cognitive system. Although color‐cognitive devices have been demonstrated, the large size, complex manufacturing, high cost, and non‐flexible processing impede their applications for distinguishing color information. Herein, gradient bandgap‐tunable perovskite microwire arrays with excellent crystallinity and pure crystallographic orientation are realized by the synergy of the capillary‐bridge assembly method and mild component engineering processing, yielding high‐performance integrated color‐cognitive devices with the spectral resolution of 14 nm ranging from 405 nm to 760 nm, responsivities over 103 A W−1, and detectivities over 1015 Jones. Furthermore, the integrated flexible color‐cognitive devices are demonstrated for accurately recognizing similar colors, which can be applied in color blindness correction. The efficient color recognition performances, together with the flexible processing, open new opportunities for the on‐chip integration of wearable devices based on microwire arrays.
Red‐Emitting Organic–Inorganic Hybrid Manganese(II) Halides for X‐Ray Imaging
Authors: Li Wen , Zhou Zhengyang , Wang Chao , Li Yunyun , Kurosawa Shunsuke , Ren Guohao , OuYang Xiaoping , Wu Yuntao 
Published: January 2023

AbstractLow‐dimensional organic–inorganic hybrid manganese(II) halides are emerging as a highly promising class of candidate materials for X‐ray imaging due to their excellent radioluminescence performance. Here, a red‐emitting (Gua)2MnCl4 (Gua = guanidine, CH6N3+) single crystal scintillator grown by a simple solution‐processing method is reported. (Gua)2MnCl4 crystallizes into a zero‐dimensional (0D) crystal structure consisting of trimeric [Mn3Cl12]6− units. It has a high PLQY of 76% and a large Stokes shift of 125 nm. (Gua)2MnCl4 flexible scintillation screen demonstrates a decent X‐ray detection limit of 145.3 nGyair s−1 and a superior imaging resolution of 8 lp mm−1. These results highlight the potential of low‐dimensional red‐emitting Mn‐based hybrids for X‐ray imaging applications.
Wide‐range color‐tunable afterglow emission by the modulation of triplet exciton transition processes based on buckybowl structure
Authors: Zhang Yongfeng , Xiong Chenchen , Wang Wenbo , Dai Wenbo , Ren Yue , Xia Junming , Li Gengchen , Shi Jianbing , Tong Bin , Zheng Xiaoyan , Shao Xiangfeng , Cai Zhengxu , Dong Yuping 
Published: January 2023

AbstractBuckybowl structures as non‐uniform electrostatic potential distributions of polycyclic aromatic materials show a unique photoelectric performance. In this work, OTC was utilized for dynamic modulation of triplet exciton transition processes. Five host molecules with different functional units were selected, thus providing different intermolecular interactions in the host/guest systems. Therefore, the delayed emissions were regulated from 536 to 624 nm via the tuning of the triplet exciton transition processes of OTC in different hosts. Experimental data and theoretical calculations revealed that the varied triplet transition behaviors resulted from the competition between the intersystem crossing (ISC) process of OTC‐monomer and the reverse intersystem crossing (RISC) process of OTC‐aggregates. This work proves the superior structure of buckybowl‐based luminophore for controlling triplet exciton transition processes and supplies a new perspective for persistent afterglow luminophore design.
Novel CRB1 pathogenic variant in Chuuk families with Leber congenital amaurosis
Authors: Albakri Amani , Pisuchpen Phattrawan , Capasso Jenina E. , Schneider Adele , Kopinsky Sarina , Glaser Tom , Chiang John P.‐W. , Yomai Anamaria Akapito , McNear Donna , Levin Alex V. 
Published: January 2023

AbstractThe purpose of this article is to determine the cause of Leber congenital amaurosis (LCA) in Chuuk state, Federated States of Micronesia (FSM). In this prospective observational case series, five patients with early‐onset vision loss were examined in Chuuk state, FSM, during an ocular genetics visit to study the elevated incidence of microphthalmia. Because of their low vision these patients were incorrectly assumed to have microphthalmia. A complete ophthalmological exam established a clinical diagnosis of LCA. Candidate gene exons were sequenced with a targeted retinal dystrophy panel. Five subjects in three related families were diagnosed with LCA. All five were from Tonoas Island, within the Chuuk Lagoon, with ages ranging from 6 months to 16 years. DNA sequencing of affected individuals revealed a homozygous CRB1 NM_201253.3:c.3134del pathogenic variant, which was heterozygous in their parents. CRB1 genotypes were confirmed by a PCR restriction assay. We report identification of a founder pathogenic variant in CRB1 responsible for autosomal recessive LCA in this isolated community. This discovery will lead to appropriate recurrence risk counseling.
A novel methodological approach for group classification during fission of a semi‐free‐ranging group of Japanese macaques (Macaca fuscata)
Authors: Hammer Roy , Stribos Mathieu S. , Boehm Pia M. , Pink Katharina E. , Herzele Julia , Wallner Bernard , Huffman Michael A. , Massen Jorg J. M. , Pflüger Lena S. 
Published: January 2023

AbstractThe self‐initiated split of a social group, known as fission, is a challenge faced by many group‐living animals. The study of group fission and the social restructuring process in real time provides insights into the mechanism of this biologically important process. Previous studies on fission in Japanese macaques (Macaca fuscata) assigned individuals to newly reorganized groups mainly using behavioral observations and group attendance records based on periods before or after fission itself. Here, we present a novel framework for group classification during the process of fission that uses quantifiable behavioral variables and statistical analyses. The framework was tested on a group fission process at Affenberg Landskron (Austria), a park that housed around 160 semi‐free‐ranging Japanese macaques. The behavioral data were collected for 26 days during fission. We analyzed three behavioral developments recurrent in fissions in Japanese macaques, that is, independence of behavior, participation in group movements, and separation of nomadic ranges. These analyses were combined to assign individuals to different groups. Our study resulted in one main group (N = 33), one subgroup (N = 36) and 56 individuals whose group membership was still undefined. The demographic characteristics of these newly formed groups were comparable with those of fissioned groups in wild populations. Furthermore, we found that these newly forming groups showed early social dynamics of fission five months before group level movements, that is: grouping based on spatial proximity and spatial withdrawal of the subgroup to the periphery. These results underline the validity of our novel framework to study social dynamics in Japanese macaques during the process of fission. It represents an important addition to existing methods, and we recommend testing its scope in other primate societies.
A Catalytic Method for the Enantioselective Synthesis of α‐Quaternary Ketones, α‐Ketoesters and Aldehydes
Authors: Wheatley Emilie , Zanghi Joseph M. , Mason Miles M. , Meek Simon J. 
Published: January 2023

AbstractA practical method for the efficient and enantioselective preparation of versatile ketones and aldehydes that contain an α‐quaternary stereocenter is described. Reactions utilize simple carboxylic acid or ester starting materials, a monodentate chiral phosphine, and afford a variety of aryl, alkenyl, alkynyl, and alkyl‐substituted ketone and aldehyde products in 25–94 % yield and 90 : 10 to >99 : 1 enantiomeric ratio. Reactions proceed by acyl substitution with in situ formed chiral allylic nucleophiles, and display selectivity and conversion dependence on a protic additive. The utility of the approach is demonstrated through several product transformations.
Step by Step Induced Growth of Zinc‐Metal Interface on Graphdiyne for Aqueous Zinc‐Ion Batteries
Authors: Luan Xiaoyu , Qi Lu , Zheng Zhiqiang , Gao Yaqi , Xue Yurui , Li Yuliang 
Published: January 2023

AbstractRechargeable aqueous zinc ion batteries (AZIBs) promise high energy density, low redox potential, low cost and safety; however, their cycle performances are seriously insufficient to restrict the progress in this field. We propose a new concept of atomic electrode formed on the graphdiyne (GDY). This new idea electrode was synthesized by selectively, uniformly, and stably anchoring Zn atoms on GDY at the beginning of plating. The Zn atoms are induced to grow into larger size Zn clusters, which continue to grow into nanoflat. Finally, a new heterojunction interface is formed on GDY without any Zn dendrites and side reactions, even at high current densities. Such stepwise induction of growth greatly suppresses the formation of Zn dendrites, resulting in high electroplating/stripping reversibility and lifespan of AZIBs.
Polymer in hemostasis and follow‐up wound healing
Authors: Sasmal Pradyumna Kumar , Ganguly Somenath 
Published: January 2023

AbstractPolymers offer unique functional properties that lead to some novel applications every other day. Bioactive polymers with high degree of biodegradability, nonimmunogenicity, and biocompatibility are considered for applications in wound healing. The most basic form of wound protection is by gauge dressing that isolates the wound from contaminants. Natural polymers for example, cellulose, alginate, chitosan, starch, dextran, gelatin, hyaluronic acid, glycan, collagen, and synthetic polymers including polymethyl methacrylate (PMMA), polyvinyl alcohol (PVA), polyethylene glycol (PEG), polyvinyl pyrrolidone (PVP) are candidates for these applications. Biopolymers, when applied as wound dressing promote tissue healing and repair by (i) regulating the moist environment, and (ii) providing the needed growth factors, while offering anti‐inflammatory, immune‐modulatory, and cell proliferative properties. It induces hemostasis via direct interaction with erythrocytes and platelets. These polymers in cross linked state offer a scaffold for cell proliferation, differentiation, and cell migration. Further, these polymeric materials can be utilized to form permeable envelopes around the hemostatic and wound healing agents to leverage a favorable release kinetics. The fabrication strategies and their reported efficacy are reviewed in this article.
Simultaneously improving of thermal resistance and mechanical performances of cyclic olefin copolymers by incorporation of bulky adamantane side group
Authors: Deng Bo , Wang Xuling , Wu Jiajun , Wu Huilin , Wang Kaiti 
Published: January 2023

AbstractDue to the low toxicity, excellent thermal resistance, optical performances and dielectric properties, cyclic olefin copolymers (COCs) could be widely applied in manufacturing of food and medicine package, optical components, electronic device, and so forth. However, most of the commoditized COCs possessing glass transition temperatures (Tgs) higher than 150°C always show non‐ignorable mechanical brittleness. Herein, a bulky cyclic olefin, 5‐norboenene‐2,3‐dicarboxylicacid‐adamantan‐1‐yl ester (NBDAE), was synthesized by one step reaction in high yields and subsequently employed to copolymerize with cis‐cyclooctene (COE), affording a series of COCs bearing bulky adamantane side group. Due to the incorporation of the bulky norbornene derivative (NBDAE), the obtained COCs exhibited high Tgs (up to 216°C) and transparency (higher than 90%), even at relatively low NBDAE incorporations. As expected, the NBDAE‐COE copolymers also showed improved mechanical properties compared to commercialized Zeonex® 330R (Stress at break: 39.1 MPa, strain at braek: 2.3%). Most of the synthesized COCs showed thermal decomposition temperatures (Tds) higher than 300°C and did not decompose under maintaining at 250°C for 1 h. Considering the performances mentioned above, the prepared COCs would show more greatly potential application in various fields.
Evolutionary insights from an anatomical network analysis of the hyolaryngeal apparatus in extant archosaurs (birds and crocodilians)
Authors: Yoshida Junki , Kobayashi Yoshitsugu , Fiorillo Anthony R. 
Published: January 2023

AbstractAdaptive radiation of archosaurs, represented by crocodilians, non‐avian dinosaurs, and birds, since the Mesozoic has been studied mainly based on their major skeletal elements (skull, vertebrae, and limbs). However, little is known about the evolution of their hyolaryngeal apparatus, which is involved with feeding, respiration, and vocalization, because of poor fossil preservation and the difficulty in determining the musculoskeletal homology of the apparatus. Network analysis is a framework to quantitatively characterize the topological organization of anatomical structures for comparing structural integration and modularity regardless of ambiguous homology. Herein, we modeled the musculoskeletal system of hyolarynx in six species of extant archosaurs and its sister‐taxon turtle, and conducted a network analysis using network parameters, modular partition, and bone centrality in a phylogenetic framework. The network parameters reveal that ancestral archosaurs have reduced the numbers of elements and links and acquired complex networks as a whole domain with strong modularity in the hyolarynx. Furthermore, the modular partition and centrality reveal that the hyoids are highly evolvable, while the larynx is constrained and less evolvable. The archosaur hyolarynx exhibits different evolutionary trends: crocodilians with the system integration, basihyal simplification, and ceratobranchial centralization; and birds with the simplicity, weak integration, and modularity of the hyolarynx, laryngeal integration with cricoid centrality, and tongue‐module expansion with the acquisition of paraglossal. Four hyolaryngeal bones (ceratobranchial, basihyal, paraglossal, and cricoid) have played important roles in archosaur evolution, and their fossil records are keys to understanding the two major archosaur lineages toward crocodilians and birds.
Fractional‐order dynamics and adaptive dynamic surface control of flexible‐joint robots
Authors: Cheng Chao , Shen Haikuo 
Published: January 2023

AbstractThis paper establishes a novel fractional‐order model for n‐links flexible‐joint (FJ) robots and proposes an adaptive dynamic surface control (DSC) scheme to address the tracking control problem. The fractional‐order FJ model is built by fractional‐order viscoelastic dynamics model to have a more concise form. An adaptive DSC strategy is proposed to address the tracking control problem based on backstepping method. By selecting the appropriate orders for fractional filters, the controller could solve the “explosion of complexity” problem. The unknown nonlinearities of FJ robot systems are approximated by Radial basis function (RBF) neural networks (NNs). Based on the Lyapunov stability theory, the bounds of all signals in the closed‐loop system are achieved. The simulation results confirm the effectiveness of the presented control scheme.