bluuebunny/crossref_metadata_2025_split huggingface dataset:
A power allocation strategy for fuel cell ship considering fuel cell performance difference
Authors: Cao Wei , Geng Pan , Xu Xiaoyan , Guo Yi , Ma Zhanxin 
Published: June 2023

AbstractThis paper focuses on designing a power allocation strategy for a fuel cell ship. The performance of the fuel cell varies during operation, so a power allocation strategy considering fuel cell performance differences is proposed, which consists of two layers. In the first layer, the maximum power and maximum efficiency of each fuel cell system (FCS) are updated in real-time with an online parameter identification model, which is composed of the fuel cell semi-empirical model and adaptive Kalman filter. The second layer takes the state of charge of the battery energy storage system, the maximum power, and the maximum efficiency as inputs for power allocation. Compared with the equal allocation strategy and daisy chain strategy, the total hydrogen consumption reduces by 5.3% and 15.1% and the total output power of the FCS with poor performance reduces by 14.1% and 15.7%. The results show that the proposed method can improve the efficiency of the ship power system and reduce the operational burden of the FCS with poor performance.
Effects of high-intensity focused ultrasound combined with levonorgestrel-releasing intrauterine system on patients with adenomyosis
Authors: Cai Yuru , Sun Yanan , Xu Feng , Wu Yunzhe , Ren Chunfeng , Hao Xiaohong , Gao Bulang , Cao Qinying 
Published: June 2023

AbstractIt is very important to treat adenomyosis which may cause infertility, menorrhagia, and dysmenorrhea for women at the reproductive age. High-intensity focused ultrasound (HIFU) is effective in destroying target tumor tissues without damaging the path of the ultrasound beam and surrounding normal tissues. The levonorgestrel-releasing intrauterine system (LN-IUS) is a medical system which is inserted into the uterine to provide medicinal treatment for temporary control of the symptoms caused by adenomyosis. This study was to investigate the effect of HIFU combined with the LN-IUS on adenomyosis. In the HIFU treatment, the parameters of the ultrasound were transmission frequency 0.8 MHz and input power 50–400 W (350 ± 30), and the temperature in the target tissue under these conditions would reach 60–100 °C (85 °C ± 6.3 °C). Size reduction and blood flow signal decrease were used to assess the effect of combined treatment. In this study, 131 patients with adenomyosis treated with HIFU combined with LN-IUS were retrospectively enrolled. The clinical and follow-up data were analyzed. After treatment, the volume of the uterine lesion was significantly decreased with an effective rate of 72.1%, and the adenomyosis blood flow signals were significantly reduced, with an effective rate of 71.3%. At six months, the menstrual cycle was significantly (P < 0.05) decreased from 31.4 ± 3.5 days before treatment to 28.6 ± 1.9 days, the menstrual period was significantly shortened from 7.9 ± 1.2 days before HIFU to 6.5 ± 1.3 days, and the menstrual volume was significantly (P < 0.05) decreased from 100 to 49% ± 13%. The serum hemoglobin significantly (P < 0.05) increased from 90.8 ± 6.2 g/L before treatment to 121.6 ± 10.8 g/L at six months for patients with anemia. Among seventy-two (92.3%) patients who finished the six-month follow-up, sixty-five (90.3%) patients had the dysmenorrhea completely relieved, and the other seven (9.7%) patients had only slight dysmenorrhea which did not affect their daily life. Adverse events occurred in 24 (18.3%) patients without causing severe consequences, including skin burns in two (1.5%) patients, skin swelling in four (3.1%), mild lower abdominal pain and low fever in 15 (11.5%), and subcutaneous induration in three (2.3%). Six months after treatment, no other serious side effects occurred in any patients with follow-up. In conclusions, the use of high-intensity focused ultrasound combined with the levonorgestrel-releasing intrauterine system for the treatment of adenomyosis is safe and effective even though the long-term effect remains to be confirmed.
Differential and cooperative effects of IL-25 and IL-33 on T helper cells contribute to cryptococcal virulence and brain infection
Authors: Hansakon Adithap , Jeerawattanawart Siranart , Angkasekwinai Pornpimon 
Published: June 2023

AbstractThe epithelial cell-derived cytokines IL-33 and IL-25 are important mediators in driving type-2 inflammation during C. neoformans infection. Nevertheless, the impact of these cytokines in regulating host T helper cell response during C. neoformans infection is still unclear. We observed that C. neoformans infection promoted a predominant increase of T helper cells that co-expressed IL-25 and IL-33 receptors within the lung during the late infection phase. A comparative transcriptomic analysis of effector T helper cells co-treated with IL-25 and IL-33 revealed a cooperative effect of these cytokines in promoting IL-13 gene expression. Without IL-25 receptor signaling, IL-33 treatment upregulated Th1-associated genes and genes associated with nucleotide metabolism. By contrast, IL-25 had a unique effect in enhancing type-2 cytokines IL-5 and IL-9 and chemokine CCL24, as well as genes in the pathways that are associated with L-arginine metabolisms. Interestingly, this pathogenic T helper cell population that expressed IL-25 and IL-33 receptors was greatly enriched in mice that were infected with high cryptococcal virulence and associated with fungal burdens in the brain. Therefore, our data further provide the additional function of IL-25 and IL-33 in potentiating cryptococcal brain dissemination.
Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases
Authors: Kleiner Victoria A. , O. Fischmann Thierry , Howe John A. , Beshore Douglas C. , Eddins Michael J. , Hou Yan , Mayhood Todd , Klein Daniel , Nahas Debbie D. , Lucas Bob J. , Xi He , Murray Edward , Ma Daphne Y. , Getty Krista , Fearns Rachel 
Published: June 2023

AbstractRespiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are related RNA viruses responsible for severe respiratory infections and resulting disease in infants, elderly, and immunocompromised adults1–3. Therapeutic small molecule inhibitors that bind to the RSV polymerase and inhibit viral replication are being developed, but their binding sites and molecular mechanisms of action remain largely unknown4. Here we report a conserved allosteric inhibitory site identified on the L polymerase proteins of RSV and HMPV that can be targeted by a dual-specificity, non-nucleoside inhibitor, termed MRK-1. Cryo-EM structures of the inhibitor in complexes with truncated RSV and full-length HMPV polymerase proteins provide a structural understanding of how MRK-1 is active against both viruses. Functional analyses indicate that MRK-1 inhibits conformational changes necessary for the polymerase to engage in RNA synthesis initiation and to transition into an elongation mode. Competition studies reveal that the MRK-1 binding pocket is distinct from that of a capping inhibitor with an overlapping resistance profile, suggesting that the polymerase conformation bound by MRK-1 may be distinct from that involved in mRNA capping. These findings should facilitate optimization of dual RSV and HMPV replication inhibitors and provide insights into the molecular mechanisms underlying their polymerase activities.
Identification of biomarkers and immune infiltration in acute myocardial infarction and heart failure by integrated analysis
Authors: Liu Wei , Li Yuling , Zhang Yan , Li Su , Chen Yuqiong , Han Bing , Lu Yao 
Published: June 2023

Abstract
The mortality of heart failure after acute myocardial infarction (AMI) remains high. The aim of the present study was to analyze hub genes and immune infiltration in patients with AMI and heart failure (HF). The study utilized five publicly available gene expression datasets from peripheral blood in patients with AMI who either developed or did not develop HF. The unbiased patterns of 24 immune cell were estimated by xCell algorithm. Single-cell RNA sequencing data were used to examine the immune cell infiltration in heart failure patients. Hub genes were validated by quantitative reverse transcription-PCR (RT-qPCR). In comparison with the coronary heart disease (CHD) group, immune infiltration analysis of AMI patients showed that macrophages M1, macrophages, monocytes, natural killer (NK) cells, and NKT cells were the five most highly activated cell types. Five common immune-related genes (S100A12, AQP9, CSF3R, S100A9, and CD14) were identified as hub genes associated with AMI. Using RT-qPCR, we confirmed FOS, DUSP1, CXCL8, and NFKBIA as the potential biomarkers to identify AMI patients at risk of HF. The study identified several transcripts that differentiate between AMI and CHD, and between HF and non-HF patients. These findings could improve our understanding of the immune response in AMI and HF, and allow for early identification of AMI patients at risk of HF.
Amyloids and brain cancer: molecular linkages and crossovers
Authors: Singh Shalini , Joshi Vibhuti , Upadhyay Arun 
Published: June 2023

AbstractAmyloids are high-order proteinaceous formations deposited in both intra- and extracellular spaces. These aggregates have tendencies to deregulate cellular physiology in multiple ways; for example, altered metabolism, mitochondrial dysfunctions, immune modulation, etc. When amyloids are formed in brain tissues, the endpoint often is death of neurons. However, interesting but least understood is a close connection of amyloids with another set of conditions in which brain cells proliferate at an extraordinary rate and form tumor inside brain. Glioblastoma is one such condition. Increasing number of evidence indicate a possible link between amyloid formation and depositions in brain tumors. Several proteins associated with cell cycle regulation and apoptotic pathways themselves have shown to possess high tendencies to form amyloids. Tumor suppressor protein p53 is one prominent example that mutate, oligomerize and form amyloids leading to loss- or gain-of-functions and cause increased cell proliferation and malignancies. In this review article, we present available examples, genetic links and common pathways that indicate that possibly the two distantly placed pathways: amyloid formation and developing cancers in the brain have similarities and are mechanistically intertwined together.
All these screens that we’ve done: how functional genetic screens have informed our understanding of ribosome biogenesis
Authors: Harold Cecelia M. 
Published: June 2023

Abstract
Ribosome biogenesis is the complex and essential process that ultimately leads to the synthesis of cellular proteins. Understanding each step of this essential process is imperative to increase our understanding of basic biology, but also more critically, to provide novel therapeutic avenues for genetic and developmental diseases such as ribosomopathies and cancers which can arise when this process is impaired. In recent years, significant advances in technology have made identifying and characterizing novel human regulators of ribosome biogenesis via high-content, high-throughput screens. Additionally, screening platforms have been used to discover novel therapeutics for cancer. These screens have uncovered a wealth of knowledge regarding novel proteins involved in human ribosome biogenesis, from the regulation of the transcription of the ribosomal RNA to global protein synthesis. Specifically, comparing the discovered proteins in these screens showed interesting connections between large ribosomal subunit (LSU) maturation factors and earlier steps in ribosome biogenesis, as well as overall nucleolar integrity. In this review, a discussion of the current standing of screens for human ribosome biogenesis factors through the lens of comparing the datasets and discussing the biological implications of the areas of overlap will be combined with a look toward other technologies and how they can be adapted to discover more factors involved in ribosome synthesis, and answer other outstanding questions in the field.
Effects of Aided Communication on Communicative Participation for People With Amyotrophic Lateral Sclerosis
Authors: Peters Betts , Wiedrick Jack , Baylor Carolyn 
Published: June 2023

Purpose:
Many people with amyotrophic lateral sclerosis (PALS) experience speech changes, which may interfere with participation in communication situations. This study was designed to investigate the effects of aided communication on self-rated communicative participation among PALS and the relationship between speech function and communicative participation for PALS at various stages of speech impairment and communication aid use.

Method:
Participants with amyotrophic lateral sclerosis completed an online questionnaire in which they identified their current communication methods, rated their speech function, and rated their communicative participation in various situations on a modified version of the Communicative Participation Item Bank short form. PALS who reported using aided communication rated their communicative participation under two conditions: with unaided communication only and with access to all of their communication methods.

Results:
Communication aids appeared to support communicative participation for many participants with dysarthria. Across all levels of speech function, PALS who use aided communication reported better participation under the all-methods condition than the unaided-only condition, with the largest benefits for participants with anarthria (Revised ALS Functional Rating Scale [ALSFRS-R] speech rating = 0). Communicative participation ratings worsened with more severe speech impairment under both conditions for most levels of speech function, but PALS with anarthria (ALSFRS-R speech rating = 0) reported better participation under the all-methods condition than those who used residual speech in combination with non speech methods (ALSFRS-R speech rating = 1).

Conclusions:
Aided communication can help PALS continue to participate in various communication situations as their speech function deteriorates. Variability in self-rated communicative participation, even for PALS at the same level of speech function, highlights the need for an individualized approach and consideration of personal and environmental factors in augmentative and alternative communication intervention.

Supplemental Material:

https://doi.org/10.23641/asha.22782986
Test–Retest Reliability of Microlinguistic Information Derived From Spoken Discourse in Persons With Chronic Aphasia
Authors: Stark Brielle C. , Alexander Julianne M. , Hittson Anne , Doub Ashleigh , Igleheart Madison , Streander Taylor , Jewell Emily 
Published: June 2023

Purpose:
The purpose of this study was to characterize test–retest reliability of discourse measures across a battery of common tasks in individuals with aphasia and prospectively matched adults without brain damage.

Method:

We collected spoken discourse during five monologue tasks at two timepoints (test and retest; within 2 weeks apart) in an aphasia group (
n
= 23) and a peer group with no brain damage (
n
= 24). We evaluated test–retest reliability for percentage of correct information units, correct information units per minute, mean length of utterance, verbs per utterance, noun/verb ratio, open/closed class word ratio, tokens, sample duration (seconds), propositional idea density, type–token ratio, and words per minute. We explored reliability's relationship with sample length and aphasia severity.

Results:
Rater reliability was excellent. Across tasks, both groups demonstrated discourse measures with poor, moderate, and good reliability, with the aphasia group having measures demonstrating excellent test–retest reliability. When evaluating measures within each task, test–retest reliability again ranged from poor to excellent for both groups. Across groups and task, measures that appeared most reliable appeared to reflect lexical, informativeness, or fluency information. Sample length and aphasia severity impacted reliability, and this differed across and by task.

Conclusions:
We identified several discourse measures that were reliable across and within tasks. Test–retest statistics are intimately linked to the specific sample, emphasizing the importance of multiple baseline studies. Task itself should be considered an important variable, and it should not be assumed that discourse measures found to be reliable across several tasks (averaged) are likewise reliable for a single task.

Supplemental Material:

https://doi.org/10.23641/asha.23298032
The scaling relations of galaxies back in time: The road toward virialization
Authors: D’Onofrio M. , Chiosi C. 
Published: June 2023

Context. The structural scaling relations (SSRs) of galaxies, that is, the observed correlations between effective radius, effective surface intensity, and velocity dispersion, are important tools for understanding how evolution proceeds.
Aims. In this paper, we aim to demonstrate that the evolution of the SSRs back in time is governed by a combination of virial theorem (VT) and the relation L = L0′(t)σβ(t), where the parameters β and L0′ vary with time and from galaxy to galaxy.
Methods. Using the WINGS database for the galaxies at redshift z = 0 and the Illustris-1 and IllustrisTNG databases of artificial galaxies, for the galaxies up to redshift z = 4, we analyse the SSRs back in time and, by means of simple algebraic expressions for L0′ and β (functions of time and other physical quantities), we derive the expected paths followed by galaxies in the various SSRs toward the distributions observed at z = 0.
Results. The distribution of galaxies in the SSRs is ultimately related to the evolution in luminosity and velocity dispersion, which are empirically mirrored by the L = L0′(t)σβ(t) law. Furthermore, the β parameter works as a thermometer of the virialization of a galaxy. This parameter can assume either positive or negative values, and its absolute value attains high values when the galaxy is close to the virial condition, while it tends to zero when the galaxy is far from this condition.
Conclusions. As the SSRs change with time, the method proposed in this paper allows us to decipher the temporal evolution of galaxies.
Variable stars in the residual light curves of OGLE-IV eclipsing binaries towards the Galactic Bulge
Authors: Ádám R. Z. , Hajdu T. , Bódi A. , Hajdu R. , Szklenár T. , Molnár L. 
Published: June 2023

Context. The Optical Gravitational Lensing Experiment (OGLE) observed around 450 000 eclipsing binaries (EBs) towards the Galactic Bulge. Decade-long photometric observations such as these provide an exceptional opportunity to thoroughly examine the targets. However, observing dense stellar fields such as the Bulge may result in blends and contamination by close objects.
Aims. We searched for periodic variations in the residual light curves of EBs in OGLE-IV and created a new catalogue for the EBs that contain ‘background’ signals after the investigation of the source of the signal.
Methods. From the about half a million EB systems, we selected those that contain more than 4000 data points. We fitted the EB signal with a simple model and subtracted it. To identify periodical signals in the residuals, we used a GPU-based phase dispersion minimisation python algorithm called cuvarbase and validated the found periods with Lomb-Scargle periodograms. We tested the reliability of our method with artificial light curves.
Results. We identified 354 systems where short-period background variation was significant. In these cases, we determined whether it is a new variable or just the result of contamination by an already catalogued nearby one. We classified 292 newly found variables into EB, δ Scuti, or RR Lyrae categories, or their sub-classes, and collected them in a catalogue. We also discovered four new doubly eclipsing systems and one eclipsing multiple system with a δ Scuti variable, and modelled the outer orbits of the components.
Neuroprotektive Wirkungen von Antidiabetika in der Therapie von Patienten mit Diabetes und Glaukom oder hohem Glaukomrisiko
Authors: Weisser Burkhard , Erb Carl 
Published: June 2023

ZusammenfassungDas Glaukom ist mit zahlreichen Risikofaktoren und internistischen Erkrankungen wie Diabetes mellitus Typ 2 verbunden. Der Typ-2-Diabetes-mellitus führt peripher und im Gehirn zu neurodegenerativen Veränderungen. Möglicherweise liegt in der Neurodegeneration auch eine Gemeinsamkeit in der Pathophysiologie und Ätiologie beider Erkrankungen. Interessanterweise scheinen zahlreiche Medikamente zur Therapie des Diabetes mellitus unabhängig von der Senkung des Blutzuckers neuroprotektive Eigenschaften aufzuweisen. Obwohl prospektive, randomisierte klinische Studien dazu noch fehlen, scheinen besonders Metformin und Glucagon-like-Peptide-1-Receptor-Agonisten (GLP-1-RA) neuroprotektive Effekte aufzuweisen. Die immer noch sehr häufig eingesetzten Sulfonylharnstoffe (z. B. Glibenclamid, Glimepirid) senken zwar sehr potent den Blutzucker, haben bez. der Neuroprotektion wohl vergleichsweise weniger Effekte. In der vorliegenden Übersicht werden diese unterschiedlich ausgeprägten
neuroprotektiven Befunde dargestellt und eine mögliche Differenzialtherapie für Diabetiker mit Glaukom oder erhöhtem Glaukomrisiko in der Praxis diskutiert.
Pharmacological Interventions for Glucocorticoid-Induced
Osteoporosis: An Umbrella Review
Authors: Liang Haodong , Zhao Jinlong , Tian Tianzhao 
Published: June 2023

AbstractThere is still a lack of high-quality evidence-based studies on the efficacy of
drug treatment for glucocorticoid-induced osteoporosis (GIOP). The purpose of
this umbrella review is to comprehensively evaluate the existing evidence to
determine the efficacy and safety of pharmacological interventions for GIOP. We
searched PubMed, Embase, and the Cochrane Library for systematic reviews
and/or meta-analyses (SRs) of randomized controlled trials (RCTs) aimed
at evaluating drug therapy for GIOP. Both the methodological quality and the
strength of recommendation of the endpoints included in the SRs were evaluated
by using the AMSTAR-2 tool and GRADE system, respectively. Six SRs involving
7225 GIOP patients in 59 RCTs were included in this umbrella review. The results
of the methodological quality evaluation showed that 2 high-quality, 2
low-quality and 2 critically low-quality SRs were included. The GRADE evaluation
results showed that the quality of evidence and the strength of recommendation
of 46 outcome indicators were evaluated in the umbrella review; there were 3
with high-level evidence, 20 with moderate-level evidence, 15 with low-level
evidence, and 8 with very low-level evidence. Moderate- to high-level evidence
suggests that teriparatide, bisphosphonates, and denosumab can improve the bone
mineral density in patients with GIOP. The findings of this umbrella review can
enable patients and clinical healthcare professionals to choose the best drug
prescription.
Visible-Light-Induced Metal-Free Selenation of Tryptamines/3-Substituted Indoles
Authors: Singh Ravi P. , Singh Shashank , Naskar Kalyan S. , Kundu Arindam 
Published: June 2023

AbstractVisible-light-mediated novel metal-free, oxidant-free phosphoric acid-catalyzed method for the synthesis of 2-selanyl NHCbz-tryptamines/3-subtituted indoles is presented. This direct C-2 selenation strategy, with environmental benign conditions by reaction of tryptamines/3-substituted indoles and diaryl/dialkyl selenides, allows access to a wide range of 2-aryl/alkylselanyl NHCbz-tryptamines/3-substituted indoles. An experimental investigation using UV/Vis, cyclic voltammetry, and controlled experiments sheds light on the plausible mechanism.