bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐sided? Operation mode of sharing economy enterprises
Authors: Weng Zhicheng , Luo Pinliang 
Published: March 2023

AbstractTurning to the theoretical methods of two‐sided markets, we analyze the operation mode selection of the sharing economy. Considering the interactions of the operating enterprise, resource suppliers (basic service providers), value‐added service providers, and consumers, we show that the selection of one‐sided mode, two‐sided mode, or multi‐sided mode depends on enterprise service quality, pricing power and cross‐group externalities of sharing economy service, utility evaluation and access cost of the value‐added service. Further, we give a theoretical explanation of the operation mode evolution in China's online car‐hailing market and put forward two specific multi‐sided platform development paths.
Polygenic Parkinson's Disease Genetic Risk Score as Risk Modifier of Parkinsonism in Gaucher Disease
Authors: Blauwendraat Cornelis , Tayebi Nahid , Woo Elizabeth Geena , Lopez Grisel , Fierro Luca , Toffoli Marco , Limbachiya Naomi , Hughes Derralynn , Pitz Vanessa , Patel Dhairya , Vitale Dan , Koretsky Mathew J. , Hernandez Dena , Real Raquel , Alcalay Roy N. , Nalls Mike A. , Morris Huw R. , Schapira Anthony H.V. , Balwani Manisha , Sidransky Ellen 
Published: March 2023

AbstractBackgroundBiallelic pathogenic variants in GBA1 are the cause of Gaucher disease (GD) type 1 (GD1), a lysosomal storage disorder resulting from deficient glucocerebrosidase. Heterozygous GBA1 variants are also a common genetic risk factor for Parkinson's disease (PD). GD manifests with considerable clinical heterogeneity and is also associated with an increased risk for PD.ObjectiveThe objective of this study was to investigate the contribution of PD risk variants to risk for PD in patients with GD1.MethodsWe studied 225 patients with GD1, including 199 without PD and 26 with PD. All cases were genotyped, and the genetic data were imputed using common pipelines.ResultsOn average, patients with GD1 with PD have a significantly higher PD genetic risk score than those without PD (P = 0.021).ConclusionsOur results indicate that variants included in the PD genetic risk score were more frequent in patients with GD1 who developed PD, suggesting that common risk variants may affect underlying biological pathways. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Terahertz waveguide multiplexers: A review
Authors: Tan Zhen , Zhang Qin‐Yi , Lei Ya‐Lin , Zhao Yun , Ding Jiang‐Qiao 
Published: March 2023

AbstractTerahertz (THz) band, which owns abundant and underexplored frequency spectrum, has provided rich scientific and technological opportunities in numerous research fields, such as radio astronomy, atmospheric science and high‐speed communication. As one of the key components in THz systems, the multiplexer cannot only separate/combine different bands, but can also promote the development of THz instruments toward wider band and more multibands. Thanks to the high‐precision computer numerical control milling and micromachining technologies, a lot of THz waveguide multiplexers have been reported in recent years. According to the classification of design configurations, this article offers a brief overview on the developed THz multiplexers. In addition, the performance and system applications of different waveguide‐typed multiplexers are discussed. Therefore, this review will provide a valuable reference for the further development of THz waveguide multiplexers with high performance.
A 24.25–30 GHz radio frequency up‐down converter with harmonic distortions rejection for 5G millimeter wave radio channel emulator applications
Authors: Zheng Sidou , Hou Debin , Wang Chen , Zhou Peigen , Chen Jixin , Hong Wei 
Published: March 2023

AbstractIn this paper, a 24.25–30 GHz fully integrated radio frequency (RF) up‐down converter with harmonic distortions rejection for 5G millimeter wave radio channel emulator applications is proposed and implemented in a 0.1‐μm GaAs pseudomorphic high‐electron‐mobility transistor technology. The RF up‐down converter integrates a frequency doubling amplifier chain local oscillator, a harmonic suppression mixer, and three frequency selective filters for unwanted harmonics suppression. To prevent the unwanted harmonics from leaking into the RF band, a higher sideband and high‐intermediate frequency mixer core with harmonic suppression filters is proposed. With this method, the unwanted harmonics are well suppressed. To effectively reduce the chip area, a miniaturized Marchand Balun based on a folded structure is proposed. The measured results demonstrate good in‐band spectral purity with more than 70 dB suppression of unwanted harmonics. Benefit from the high‐side injection mixing scheme and harmonics suppression method, the presented up‐down converter achieves a dynamic power range of −100 to −5 dBm with a conversion loss of 10 dB. The implemented RF up‐down converter occupies only 0.9 × 2.7 mm2in size, with a power consumption of 400 mW under 4‐V supply.
Revisiting aliasing noise to build more robust sparsity in nonuniform sampling 2D‐NMR
Authors: Cullen Lucille E. , Marchiori Alan , Rovnyak David 
Published: March 2023

AbstractA continuing priority is to better understand and resolve the barriers to using nonuniform sampling (NUS) in challenging small molecule 2D NMR with subsampling of the Nyquist grid (a.k.a. coverage) below 50%. Possible causes for artifacts, often termed sampling noise, in 1D‐NUS of 2D‐NMR are revisited here, where weak aliasing artifacts are a growing concern as NUS becomes sparser. As NUS schedules become sparser, repeat sequences are shown to occur in the dense sampling regions early in the sampling schedule, causing aliasing artifacts in resulting spectra. An intuitive screening approach that detects patterns in sampling schedules based on a convolutional filter was implemented. Sampling schedules that have low proportions of repeat sequences show significantly reduced artifacts. Another route to remediate early repeat sequences is a short period of uniform sampling at the beginning of the schedule, which also leads to a significant suppression of unwanted sampling noise. Combining the repeat sequence filter with a survey of HSQC and LR‐HSQMBC experiments, it is shown that very short initial uniform regions of about 2%–4% of the sampling space can ameliorate repeat sequences in sparser NUS and lead to robust spectral reconstructions by iterative soft thresholding (IST), even when the point spread function is unchanged. Using the principles developed here, a suite of ‘one‐click’ schedules was developed for broader use.
Synthese im Blickpunkt: Bioisosteres of meta‐substituted benzenes
Authors: Bergamaschi Enrico , Teskey Christopher 
Published: March 2023

AbstractSwapping aromatic rings with small‐ring hydrocarbon cages is a promising method for synthesising more effective drugs. Until recently, however, this tactic was restricted to the replacement of para‐substituted phenyl groups. Now, two new methods describe reliable syntheses of a motif for exchanging meta‐substituted benzene rings, ushering a new cage‐motif into the mainstream and thus opening up opportunities for medicinal chemists.
Funktionale Sicherheit: Gut in Schuss
Authors: Landgraf Evelyn 
Published: March 2023

AbstractWenn eine 25 Jahre alte Verdampferanlage auf den neuesten Stand der Technik umzubauen ist, kommt es nicht nur darauf an, dass die Technik funktioniert, sondern auch darauf, dass sie sicher für Mensch und Umwelt läuft und den aktuellen Vorschriften entspricht.
Biological Investigation of the Endangered Northern Madtom in the North Channel St. Clair River
Authors: Utrup Brad E. , Hessenauer Jan-Michael , Briggs Andrew S. , Scribner Kim T. , Kanefsky Jeannette , Wills Todd C. 
Published: March 2023

Abstract
Aquatic organisms and the habitats they live in are declining globally, yet managers often lack even basic biological information for individual imperiled species. This makes assessment of the current status, management needs, and recovery targets for these species challenging. One such organism is the Northern Madtom Noturus stigmosus, a small, bottom-dwelling catfish of the family Ictaluridae. Northern Madtom are listed as endangered in the state of Michigan and the province of Ontario, with only a handful of isolated populations known in each region. To address life history uncertainties and to provide fisheries managers with baseline information to inform decision making, the Michigan Department of Natural Resources annually sampled Northern Madtom in the St. Clair River using minnow traps and amassed the largest known data set for this species. We handled 871 individuals from 2010 to 2022, with yearly catch rates ranging from 0.17 to 1.33 individuals/trap. Age estimates derived from otoliths and dorsal spines of 17 individuals showed no clear pattern of bias, indicating that nonlethally collected dorsal spines provide a suitable age estimation method. We developed an age–length key to assign ages to all individuals in our data set, calculated growth parameters, and determined that annual mortality rates across all ages ranged from 46% to 69%. Diet analysis revealed that caddisfly (order Trichoptera) larvae were the dominant prey item and fecundity averaged 178 eggs/female. We compared microsatellite allele frequencies and mitochondrial DNA haplotypes among samples collected in the St. Clair River and the Detroit River. Significant evidence of genetic structure was present, indicating limited gene flow and suggesting that separate management of these two populations may be warranted. Collectively, these data provide context for managers interested in the development of biological reference points and planning for the conservation and management of this species.
Factors affecting self‐care among community‐dwelling hypertensive older adults: A cross‐sectional study
Authors: Jung Soo Youn , Moon Kyoung Ja 
Published: March 2023

AbstractAimTo examine self‐care behaviours among older adults with hypertension and identify related factors, including cognitive function, religious belief and comorbidities.DesignA cross‐sectional study.MethodsSelf‐care behaviours included diet and health. Participants completed a survey including items on demographics, disease‐related characteristics and self‐care behaviours and underwent cognitive function tests. Data were analysed using descriptive statistics, and multiple regression analysis was performed to analyse the factors affecting self‐care.ResultsRegarding diet behaviour, older religious adults and those with higher scores on the Montreal Cognitive Assessment‐Korean version had higher levels of self‐care scores according to the HBP‐SC. Regarding health behaviour, older adults with no comorbidities had higher levels of self‐care scores according to the HBP‐SC.ConclusionFactors affecting self‐care diet behaviour include religion and Montreal Cognitive Assessment‐Korean version scores and those affecting health behaviour include comorbidities among older adults with hypertension. Therefore, to improve their self‐care behaviours, their religious practices and comorbidities should be considered, cognitive function should be assessed, and tailored education should be provided.Implications for the Profession and/or Patient CareThis study investigated factors affecting self‐care behaviours of hypertensive older adults in South Korea. The self‐care was divided into diet and health behaviours. The factors influencing diet behaviour were religion and Montreal Cognitive Assessment‐Korean version scores, and the factor influencing health behaviour was comorbidities. We also investigated self‐care behaviour patterns. Older adults with hypertension were good at controlling alcohol consumption and did not forget to fill prescriptions. However, they were poor at reading nutrition labels to check on sodium content and checking blood pressure at home. Therefore, nurses could develop interventions considering these influencing factors and behavioural patterns to improve self‐care behaviours and enhance health for older adults with hypertension.ImpactHypertension in older adults affects their health conditions and performance of self‐care behaviours. Nurses could assess self‐care based on diet and health behaviours. Additionally, further developing tailored programmes is recommended considering factors like religious belief, cognitive function and comorbidities.Reporting MethodThis study followed the STROBE guidelines.Patient or Public ContributionThis study used a convenience sample of 105 participants aged ≥ 65 years recruited from a Korean hospital.
Calculating the optimal number of nurses based on nursing intensity by patient classification groups in general units in South Korea: A cross‐sectional study
Authors: Ko Yukyung , Park Bohyun 
Published: March 2023

AbstractAimThis study aimed to calculate the total daily nursing workload and the optimal number of nurses per general unit based on the nursing intensity.DesignThis study was conducted using a cross‐sectional study.MethodsThree units at one general hospital were investigated. Patient classification according to nursing needs was performed for over 10 days in each unit in September 2018. The direct and non‐direct nursing time and nursing intensity scores were analysed using descriptive statistics.ResultsFor the internal medicine unit, the average direct nursing time per patient was 1.0, 1.5, 2.2 and 2.9 h for Groups 1, 2, 3 and 4, respectively. For the surgical unit, the average direct nursing time per patient was 0.9, 1.4, 2.1 and 2.6 h for Groups 1, 2, 3 and 4, respectively. 5 and 9 additional nurses were needed in the internal medicine and surgical nursing units.Patient ContributionThis study confirmed that the optimal number of nurses was not achieved and that the nursing intensity was very high. Long‐term efforts, such as improving the nursing environment, should be made to ensure an optimal number of nurses in various nursing units.
Impact of the Standardized Interview Offer Date Initiatives: A Survey of Otolaryngology Applicants and Programs
Authors: Standiford Taylor C. , Thorne Marc C. , Chang C.W. David , Malekzadeh Sonya , Pletcher Steven D. 
Published: March 2023

AbstractObjectiveTo investigate residency applicant and program compliance with and attitudes toward a newly implemented standardized interview offer date program.Study designCross‐sectional survey.SettingUS Otolaryngology‐Head and Neck Surgery training programs.MethodsAn electronic survey was distributed to applicants during match week in March 2022, and to program directors and program managers shortly after. The surveys included questions assessing program compliance with the standardized interview offer date as well as both applicant and program attitudes toward this newly implemented initiative.ResultsThis study achieved a 47% (263/559) response rate from applicants and 57% (68/120) from programs. Both applicants and program directors reported high program compliance with this initiative. Ninety‐six percent of program directors reported complying with releasing interview offers on 1 standardized day. Applicants endorsed a reduction in their anxiety surrounding the residency application process as well as an increased ability to engage in the fourth year of medical school as benefits of the initiative. Providing clarity surrounding the applicant's final application status and further standardization of the interview scheduling process were identified as areas for improvement.ConclusionStandardization of residency interview offer and acceptance practices is both feasible and impactful. Providing applicants with a final applicant status and further efforts to improve the interview scheduling process may continue to bolster this initiative in future years.
Advanced polymer processing technologies for micro‐ and nanostructured surfaces: A review
Authors: Kodihalli Shivaprakash Nischay , Banerjee Pratip Sankar , Banerjee Shib Shankar , Barry Carol , Mead Joey 
Published: March 2023

AbstractFunctional surfaces with attractive properties, such as superhydrophobicity and omniphobicity often rely on the synergy between intrinsic material properties and dual scale micro‐ and nano‐hierarchical structures for achieving desired wettability. Historically, engineered liquid repellent surfaces have attracted a great deal of interest from academia and industry due to their broad application prospects. Hence, for several years, there have been significant scientific efforts by researchers exploring state of the art manufacturing technologies that are efficient and yet cost effective to produce functional liquid repellent surfaces at an industrial scale. This technical review summarizes the various advanced and state of the art polymer processing technologies employed to fabricate the micro‐ and nanostructured polymer surfaces, with a special focus given to superhydrophobic and omniphobic applications. Here, we discuss the merits and limitations of each fabrication methods available for micro‐ and nanostructuring of polymer‐based surfaces. In addition, an attempt has been made to provide insight into the relationship between geometry of micro/nanostructures (size and shape) and intrinsic wettability on liquid repellency. A special section has been devoted to feature and document all commercialization efforts, including various commercially available products that were developed in the past decade. Finally, outlook and the development trend in the polymer micro‐ and nanostructured surfaces are highlighted to lead future research.
Accumulation of azafrin in the root apoplast of the medicinal plant Escobedia grandiflora might play a role in parasitism
Authors: Cardona‐Medina Edison , Santos Marisa , Nodari Rubens , Hornero‐Méndez Dámaso , Peris Arnau , Wong Darren C. J. , Matus José Tomás , Rodríguez‐Concepción Manuel 
Published: March 2023

Societal Impact StatementEscobedia grandiflora is a medicinal hemiparasite that occurs naturally in non‐forested communities in Central and South America. Parasitic plants accumulate high levels of a water‐soluble orange pigment in roots that was once among the most important food dyes in the Andean region. We conclusively address the chemical identification of this pigment and provide molecular and cellular insights on its biosynthesis and possible function.Summary

The herbaceous hemiparasite Escobedia grandiflora (Orobanchaceae) is used in traditional medicine in the Andean region. Escobedia roots accumulate high levels of an orange pigment with a significant relevance as a cooking dye that exhibits antioxidant and cardioprotective properties. Here, we aimed to confirm the chemical identity of the pigment and investigate its biosynthesis and function in Escobedia roots.
We combined metabolic and cytological analyses with de novo transcriptome assembly, gene expression studies, and phylogenetic analyses.
The pigment was conclusively shown to be azafrin, an apocarotenoid likely derived from the cleavage of β‐carotene. RNA‐seq supported by multispecies comparative transcriptome analysis and qRT‐PCR allowed to propose candidate genes for the production of azafrin in Escobedia roots. We also showed that azafrin is delivered to the root apoplast and that it accumulates in the area where the Escobedia haustorium contacts the host's root.
Our data suggest that azafrin production might rely on a carotenoid cleavage dioxygenase (CCD) different from CCD7 and that this apocarotenoid might function in the parasitism process. Together, our work represents an unprecedented step forward in our understanding of the Escobedia parasitization system.
Congenital lobar emphysema: A rare cause of respiratory failure in neonates
Authors: Rose Paul , Rana Saim , Abbey Cassie , Deskins Seth , Al‐Qatarneh Saif 
Published: March 2023

AbstractCongenital lobar overinflation, also known as congenital lobar emphysema (CLE), is an uncommon (1/20,000–30,000 live births) abnormality characterized by hyperinflation of one or more pulmonary lobes, usually with contralateral displacement of the mediastinum. While the etiology of most cases of CLE is poorly understood and labeled idiopathic, some cases are thought to be due to an intrinsic or extrinsic bronchial wall abnormality causing a ball valve mechanism with resultant hyperinflation of the affected lobe. CLE tends to have a predilection for males presenting insidiously in the first 6 months of life and have respiratory distress and progressive failure, with 50% of cases being asymptomatic at birth. Acquired forms of lobar emphysema are similar but are secondary to prolonged exposure to oxygen and positive pressure ventilation in premature infants. Clinical presentation is variable, ranging from wheezing, increased respiratory effort, cyanosis, feeding difficulties, and reflux or respiratory failure. Chest radiography (CXR) is the initial imaging obtained for any neonate with respiratory distress, which can aid in diagnosis showing overinflation, while computerized tomography (CT) remains the gold standard for confirmatory diagnosis. Treatment is variable and based on clinical severity. Some cases can be managed conservatively, while more severe cases require surgical intervention with lobectomy. Here, we present a case of a neonate in respiratory distress soon after birth, had initial improvement with supportive care, and was found to be secondary to CLE.
A molecular basis for tetramer destabilization and aggregation of transthyretin Ala97Ser
Authors: Wang Yi‐Shiang , Huang Chun‐Hsiang , Liou Gunn‐Guang , Hsueh Hsueh‐Wen , Liang Chi‐Ting , Tseng Hsi‐Ching , Huang Shing‐Jong , Chao Chi‐Chao , Hsieh Sung‐Tsang , Tzeng Shiou‐Ru 
Published: March 2023

AbstractTransthyretin (TTR)‐related amyloidosis (ATTR) is a syndrome of diseases characterized by the extracellular deposition of fibrillar materials containing TTR variants. Ala97Ser (A97S) is the major mutation reported in Taiwanese ATTR patients. Here, we combine atomic resolution structural information together with the biochemical data to demonstrate that substitution of polar Ser for a small hydrophobic side chain of Ala at residue 97 of TTR largely influences the local packing density of the FG‐loop, thus leading to the conformational instability of native tetramer, the increased monomeric species, and thus the enhanced amyloidogenicity of apo‐A97S. Based on calorimetric studies, the tetramer destabilization of A97S can be substantially altered by interacting with native stabilizers via similarly energetic patterns compared to that of wild‐type (WT) TTR; however, stabilizer binding partially rearranges the networks of hydrogen bonding in TTR variants while FG‐loops of tetrameric A97S still remain relatively flexible. Moreover, TTR in complexed with holo‐retinol binding protein 4 is slightly influenced by the structural and dynamic changes of FG‐loop caused by A97S substitution with an approximately five‐fold difference in binding affinity. Collectively, our findings suggest that the amyloidogenic A97S mutation destabilizes TTR by increasing the flexibility of the FG‐loop in the monomer, thus modulating the rate of amyloid fibrillization.