bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bovine tumor necrosis factor-alpha Increases IL-6, IL-8, and PGE2 in bovine fibroblast-like synoviocytes by metabolic reprogramming
Authors: Manosalva Carolina , Alarcon Pablo , Quiroga John , Teuber Stefanie , Carretta Maria D. , Bustamante Hedie , Lopez-Muñoz Rodrigo , Hidalgo Maria A. , Burgos Rafael A. 
Published: February 2023

AbstractLameness is a common condition in dairy cattle caused by infectious or noninfectious agents. Joint lesions are the second most common cause of lameness and can be diagnosed in association with the presentation of digit injuries. Fibroblast-like synoviocyte (FLS) are predominant cells of synovia and play a key role in the pathophysiology of joint diseases, thus increasing the expression of proinflammatory mediators. Tumor necrosis factor-alpha (TNF-α) is a potent proinflammatory cytokine involved in cyclooxygenase 2 (COX-2) and proinflammatory cytokine expression in FLS. Previously, TNF-α was demonstrated to increase hypoxia-inducible Factor 1 (HIF-1), a transcription factor that rewires cellular metabolism and increases the expression of interleukin (IL)-6 in bovine FLS (bFLS). Despite this, the proinflammatory effects of TNF-α in bFLS on metabolic reprogramming have been poorly studied. We hypothesized that TNF-α increases glycolysis and in this way controls the expression of IL-6, IL-8, and COX-2 in bFLS. Results first, gas chromatography/mass spectrometry (GC/MS)-based untargeted metabolomics revealed that bTNF-α altered the metabolism of bFLS, increasing glucose, isoleucine, leucine, methionine, valine, tyrosine, and lysine and decreasing malate, fumarate, α-ketoglutarate, stearate, palmitate, laurate, aspartate, and alanine. In addition, metabolic flux analysis using D-glucose-13C6 demonstrated an increase of pyruvate and a reduction in malate and citrate levels, suggesting a decreased flux toward the tricarboxylic acid cycle after bTNF-α stimulation. However, bTNF-α increased lactate dehydrogenase subunit A (LDHA), IL-6, IL-8, IL-1β and COX-2 expression, which was dependent on glycolysis and the PI3K/Akt pathway. The use of FX11 and dichloroacetate (DCA), an inhibitor of LDHA and pyruvate dehydrogenase kinase (PDK) respectively, partially reduced the expression of IL-6. Our results suggest that bTNF-α induces metabolic reprogramming that favors glycolysis in bFLS and increases IL-6, IL-8, IL-1β and COX-2/PGE2.
Fabrication of THz corrugated wakefield structure and its high power test
Authors: Kong H. , Chung M. , Doran D. S. , Ha G. , Kim S.-H. , Kim J.-H. , Liu W. , Lu X. , Power J. , Seok J.-M. , Shin S. , Shao J. , Whiteford C. , Wisniewski E. 
Published: February 2023

AbstractWe present overall process for developing terahertz (THz) corrugated structure and its beam-based measurement results. 0.2-THz corrugated structures were fabricated by die stamping method as the first step demonstration towards GW THz radiation source and GV/m THz wakefield accelerator. 150-$$\upmu$$
μ
m thick disks were produced from an OFHC (C10100) foil by stamping. Two types of disks were stacked alternately to form 46 mm structure with $$\sim$$
∼
170 corrugations. Custom assembly was designed to provide diffusion bonding with a high precision alignment of disks. The compliance of the fabricated structure have been verified through beam-based wakefield measurement at Argonne Wakefield Accelerator Facility. Both measured longitudinal and transverse wakefield showed good agreement with simulated wakefields. Measured peak gradients, 9.4 MV/m/nC for a long single bunch and 35.4 MV/m/nC for a four bunch trains, showed good agreement with the simulation.
A comparison of experience sampled hay fever symptom severity across rural and urban areas of the UK
Authors: Gledson Ann , Lowe Douglas , Reani Manuele , Topping David , Hall Ian , Cruickshank Sheena , Harwood Adrian , Woodcock Joshua , Jay Caroline 
Published: February 2023

AbstractHay fever affects people differently and can change over a lifetime, but data is lacking on how environmental factors may influence this. This study is the first to combine atmospheric sensor data with real-time, geo-positioned hay fever symptom reports to examine the relationship between symptom severity and air quality, weather and land use. We study 36145 symptom reports submitted over 5 years by over 700 UK residents using a mobile application. Scores were recorded for nose, eyes and breathing. Symptom reports are labelled as urban or rural using land-use data from the UK’s Office for National Statistics. Reports are compared with AURN network pollution measurements and pollen and meteorological data taken from the UK Met Office. Our analysis suggests urban areas record significantly higher symptom severity for all years except 2017. Rural areas do not record significantly higher symptom severity in any year. Additionally, symptom severity correlates with more air quality markers in urban areas than rural areas, indicating that differences in allergy symptoms may be due to variations in the levels of pollutants, pollen counts and seasonality across land-use types. The results suggest that a relationship exists between urban surroundings and hay fever symptoms.
Comparison of three full-field optical measurement techniques applied to vibration analysis
Authors: O’Donoughue Patrick , Gautier François , Meteyer Erwan , Durand-Texte Thomas , Secail-Geraud Mathieu , Foucart Félix , Robin Olivier , Berry Alain , Melon Manuel , Pézerat Charles , Pelat Adrien , Picart Pascal 
Published: February 2023

AbstractDigital image correlation, deflectometry and digital holography are some of the full-field optical measurement techniques that have matured in recent years. Their use in vibroacoustic applications is gaining attention and there is a need for cataloging their performance in order to provide, to a broad community of users and potential future users, quantitative and qualitative evaluations of these three approaches. This paper presents an experimental comparison of the three optical methods in the context of vibration measurements, along with classical reference measurements provided by an accelerometer and a laser Doppler vibrometer. The study is carried out on two mechanical structures exhibiting various vibration responses when submitted to an impact.
Scour ponds from unusually large tsunamis on a beach-ridge plain in eastern Hokkaido, Japan
Authors: Sawai Yuki , Tamura Toru , Shimada Yumi , Tanigawa Koichiro 
Published: February 2023

AbstractScour ponds from unusually large tsunamis cut across the crest of a beach ridge in Kiritappu marsh, eastern Hokkaido. No fewer than ten of these ponds were imaged by photogrammetry as elongate topographic depressions as large as 5 m by 30 m. Sediments in these ponds are underlain by unconformities that were detected with ground-penetrating radar and observed directly in cores and a slice sample. Sediment deposits in the ponds contain peat and volcanic ash layers, the ages of which suggest that the scouring occurred during tsunamis generated by spatially extensive thrust ruptures along the southern Kuril trench, most recently during the early seventeenth century and its predecessor during the thirteenth–fourteenth century. Some of the ponds appear to have been formed during one tsunami and refreshed during later successors. This evidence of recurrent erosion suggests that the shoreline may retreat as part of earthquake-related cycles of coastal uplift and subsidence.
Prevalence of perioperative asymptomatic venous thromboses of the lower extremity in 30 consecutive patients undergoing transsphenoidal surgery for Cushing’s disease
Authors: Huckhagel Torge , Atlihan Gülsen , Langer Florian , Flitsch Jörg , Rotermund Roman 
Published: February 2023

AbstractCushing´s disease is a rare endocrinological disorder which is caused by an adrenocorticotropic hormone secreting pituitary adenoma. The condition is associated with an increased risk for venous thromboembolism. While there exist reports on symptomatic venous thromboses complicating Cushing’s disease, the prevalence of incidental leg vein thromboses accompanying pituitary surgery for Cushing’s disease is yet unknown. 30 consecutive patients (9 male; age 25–77 years) with histologically confirmed Cushing’s disease underwent transsphenoidal adenomectomy between October 2018 and September 2019. All patients received perioperative pharmacological thromboprophylaxis. Whole leg compression ultrasound was performed within one week after surgery (median 2 days) to exclude leg vein thromboses (primary endpoint). Preoperative laboratory values including plasma cortisol and various coagulation parameters were evaluated as secondary outcome measures. A comparison was made between patients with and without thrombotic events (p value ≤ 0.05). A total of 2 out of 30 patients (6.7%; CI 0.8–24.1%) presented with asymptomatic perioperative deep vein thromboses of the lower legs. Thrombosis patients differed not significantly from their counterparts with respect to age, sex, and comorbidities, but preoperative morning plasma cortisol was significantly higher in patients with venous thromboses (421.0 ± 49.5 μg/l vs. 188.1 ± 78.2 μg/l; p = 0.01). Moreover, von Willebrand factor activity was markedly increased in one case (409.0%) compared to the mean value obtained from 28 patients without phlebothromboses (146.9 ± 60.7%; p < 0.01). Perioperative asymptomatic leg vein thrombosis can be found with the aid of compression ultrasound in a considerable proportion of patients undergoing transsphenoidal adenomectomy for Cushing’s disease despite the administration of pharmacological thromboprophylaxis.
Optimization of quasi-hemispherical CdZnTe detectors by means of first principles simulation
Authors: Vicini Valentina , Zanettini Silvia , Sarzi Amadè Nicola , Grill Roman , Zambelli Nicola , Calestani Davide , Zappettini Andrea , Abbene Leonardo , Bettelli Manuele 
Published: February 2023

AbstractIn this paper we present the development of quasi-hemispherical gamma-ray detectors based on CdZnTe. Among the possible single-polarity electrode configurations, such as coplanar, pixelated, or virtual Frisch-grid geometries, quasi-hemispherical detectors are the most cost-effective alternative with comparable raw energy resolution in the high and low energy range. The optimal configuration of the sensor in terms of dimension of the crystals and electrode specifications has been first determined by simulations, and successively validated with experimental measures. Spectra from different sources have been acquired to evaluate the detectors performances. Three types of detectors with different CZT volumes have been fabricated, namely 10 × 10 × 5 mm3, 15 × 15 × 10 mm3 and 20 × 20 × 10 mm3. In the case of 10 × 10 × 5 mm3 crystals, the optimum pixel size determined by our simulation tool was confirmed by experiments: the best spectroscopic resolution of 1.3% at 662 keV has been found for a 750 μm diameter pixel detector. The best energy resolution values obtained for the 15 × 15 × 10 mm3 and 20 × 20 × 10 mm3 detectors were respectively 1.7% and 2.7% at 662 keV.
Variable fluid properties analysis for thermally laminated 3-dimensional magnetohydrodynamic non-Newtonian nanofluid over a stretching sheet
Authors: Akbar Noreen Sher , Al-Zubaidi A. , Saleem S. , Alsallami Shami A. M. 
Published: February 2023

AbstractThis article is mainly focused on the viscous flow of cu-water/Methanol suspended nanofluids towards a three-dimensional stretching sheet reformed by magnetohydrodynamic phenomenon. The viscous effect is considered as temperature dependent with water treated as a base fluid. Similarity conversions are employed to set forth the non-linear equations of this physical problem. An innovative model for 3D analysis for cu-water/Methanol nanofluid with an irregular viscosity is presented in the present study. Reynold’s model of viscosity is considered in the present study. Moreover, shooting technique is employed to elaborate the non-linear coupled governing equations with the relevant boundary conditions. The physical interpretation of these numerical calculations is presented through a graphical specimen of velocity, Nusselt number, temperature, and skin friction etc. The results of present model are showing quality harmony with the results of existing model. This model is being used for manipulating and designing the surfaces such as stretching/shrinking wrapping and panting devices in nanotechnology. The results also show the significant changes in flow characteristics with changing the value of stretching parameter. It is observed that with an increasing in nanoparticles volume fraction boundary layer thickness decreases. Further, it is also observed that with an increase in viscosity parameter, temperature increases because here we are considering temperature dependent viscosity.
Once a week consumption of Western diet over twelve weeks promotes sustained insulin resistance and non-alcoholic fat liver disease in C57BL/6 J mice
Authors: Demaria Thainá Magalhães , Crepaldi Leticia Diniz , Costa-Bartuli Emylle , Branco Jessica Ristow , Zancan Patricia , Sola-Penna Mauro 
Published: February 2023

AbstractThe Western diet (high in fat and sucrose) consumption is a highly prevalent feature in the whole world, mainly due to the increasing consumption of ultra-processed foods (UPF), which are cheaper and easier-to-eat, as compared to fresh and highly nutritive meals. Epidemiological studies have associated UPF consumption with development of obesity, non-alcoholic fat liver disease (NAFLD) and insulin resistance. For molecular studies, mice fed with Western diets have been used to characterize signaling pathways involved in these diet-induced pathologies. However, these studies fed mice continuously with the diets, which is not compatible with what occurs in real life, when consumption is occasional. Here, we fed mice once-a-week with a high fat, high sucrose (HFHS) diet and compared these animals with those fed continuously with HFHS diet or with a standard diet. Our results show that after a single day of consuming HFHS, animals presented impaired oral glucose tolerance test (oGTT) as compared to control group. Although this impairment was reversed after 24 h consuming regular diet, repetition of HFHS consumption once-a-week aggravated the picture such as after 12-weeks, oGTT impairment was not reversed after 6 days under control diet. Liver steatosis, inflammation, impaired insulin signaling pathway and endoplasmic reticulum stress are similar comparing animals that consumed HFHS once-a-week with those that continuously consumed HFHS, though weekly-fed animals did not gain as much weight. Therefore, we conclude that regimen of one day HFHS plus 6 days normal diet over 12 weeks is sufficient to induce insulin resistance and NAFLD in mice.
Implementation of a constitutive model for anisotropic rocks based on modified Lade failure criterion
Authors: Liu Xiaotian , Deng Yansheng , Zou Baoping 
Published: February 2023

AbstractThe strength anisotropy for inherent anisotropic rocks presents a challenge to simulate considering the influence of intermediate principal stress. Based on the modified Lade failure criterion, a new anisotropic modified Lade criterion combining an empirical equation is established and verified using published experimental datasets of anisotropic rocks. The incremental constitutive model for anisotropic rocks is derived by using finite difference theory. The dynamic link library (DLL) module of the model is obtained by using the VC++ program, and then the model is validated against various laboratory test results. It is concluded that the proposed criterion and derived model can describe the strength anisotropy of inherent anisotropic rocks well.
Improving performance of mesoporous MOF AlTp impregnated with ionic liquids for CO2 adsorption
Authors: Noorani Narmin , Mehrdad Abbas 
Published: February 2023

AbstractIn this work, the CO2 adsorption performance of metal–organic frameworks (MOFs) impregnated with ionic liquids (ILs) was studied using quartz crystal microbalance (QCM) at the temperature of 298.15 K and pressures up to 5 bar. The hybrid composites consist of aluminum terephthalate metal–organic framework (AlTp) impregnated of 1-butyl-4-methyl pyridinium and 1-butyl-3-methylimidazolium–based ionic liquids (ILs) with different anions, viz. tetrafluoroborate ([BF4]−), thiocyanate ([SCN]−), chloride ([Cl]−), and bromide ([Br]−). ILs-impregnated AlTp synthesized was characterized using scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), the thermogravimetry analysis (TGA) and Fourier transform infrared (FTIR) spectroscopy. CO2 adsorption isotherms of the IL/AlTp composites and AlTp were measured to evaluate the ILs effect on the CO2 adsorption of the AlTp. Comparison of CO2 adsorption in ILs/AlTp with different anion ([Cl]−, [Br]−, [SCN]−, [BF4]−) reveals that CO2 adsorption in ILs/AlTp was increased in the order as: [BF4]− < [SCN]− < [Br]− < [Cl]−. The results show that [BMPyr][Cl]/AlTp the highest CO2 adsorption capacity, 2.6 times higher than that of AlTp at 5 bar and 298.15 K which helps to guide the logical design of new mixtures for gas separation applications. Also, adsorption/desorption test show that regeneration performance of [BMPyr][Cl]/AlTp is 96.53% after five consecutive cycles adsorption/desorption.
High-throughput isolation of cancer cells in spiral microchannel by changing the direction, magnitude and location of the maximum velocity
Authors: Omrani Vahid , Targhi Mohammad Zabetian , Rahbarizadeh Fatemeh , Nosrati Reza 
Published: February 2023

AbstractCirculating tumor cells (CTCs) are scarce cancer cells that rarely spread from primary or metastatic tumors inside the patient's bloodstream. Determining the genetic characteristics of these paranormal cells provides significant data to guide cancer staging and treatment. Cell focusing using microfluidic chips has been implemented as an effective method for enriching CTCs. The distinct equilibrium positions of particles with different diameters across the microchannel width in the simulation showed that it was possible to isolate and concentrate breast cancer cells (BCCs) from WBCs at a moderate Reynolds number. Therefore we demonstrate high throughput isolation of BCCs using a passive, size-based, label-free microfluidic method based on hydrodynamic forces by an unconventional (combination of long loops and U-turn) spiral microfluidic device for isolating both CTCs and WBCs with high efficiency and purity (more than 90%) at a flow rate about 1.7 mL/min, which has a high throughput compared to similar ones. At this golden flow rate, up to 92% of CTCs were separated from the cell suspension. Its rapid processing time, simplicity, and potential ability to collect CTCs from large volumes of patient blood allow the practical use of this method in many applications.
Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study
Authors: Miyake Kunio , Kushima Megumi , Shinohara Ryoji , Horiuchi Sayaka , Otawa Sanae , Akiyama Yuka , Ooka Tadao , Kojima Reiji , Yokomichi Hiroshi , Yamagata Zentaro ,   The Japan Environment and Children’s Study Group, Kamijima Michihiro , Yamazaki Shin , Ohya Yukihiro , Kishi Reiko , Yaegashi Nobuo , Hashimoto Koichi , Mori Chisato , Ito Shuichi , Yamagata Zentaro , Inadera Hidekuni , Nakayama Takeo , Iso Hiroyasu , Shima Masayuki , Kurozawa Youichi , Suganuma Narufumi , Kusuhara Koichi , Katoh Takahiko 
Published: February 2023

AbstractThe association between maternal pre-pregnancy smoking status and asthma risk is unclear. This study aimed to investigate the association between pre- and post-pregnancy maternal smoking status and bronchial asthma at 3 years of age in a large birth cohort. Data of 75,411 mother–child pairs from the Japan Environment and Children's Study (JECS) were analysed using multivariate logistic regression analysis. Overall, 7.2% of the children had bronchial asthma. The maternal smoking status before childbirth was as follows: Never = 60.0%, Quit before recognising current pregnancy = 24.1%, Quit after finding out about current pregnancy = 12.3%, and Still smoking = 3.6%. Children of mothers who sustained smoking during pregnancy had an increased risk of bronchial asthma at 3 years of age even after adjusting for pre- and postnatal covariates (adjusted odds ratio [aOR] 1.34, 95% confidence interval [CI] 1.15–1.56). Children of mothers who quit before (aOR 1.09, 95% CI 1.02–1.18) or after (aOR 1.11, 95% CI 1.01–1.23) recognising the current pregnancy had an increased risk of bronchial asthma at 3 years of age. Maternal smoking throughout pregnancy and smoking exposure pre-pregnancy or in early pregnancy increases the risk of bronchial asthma in children.
Fast simultaneous estimation of nD transport coefficients and source function in perturbation experiments
Authors: van Kampen Ricky , de Vries Jelle , Weiland Siep , de Baar Marco , van Berkel Matthijs 
Published: February 2023

AbstractIn the calculation of transport coefficients from experimental data precise knowledge of the source is usually assumed, while the identification of the coefficients focuses on specific geometries and one spatial variable. This paper presents a method for the simultaneous estimation of both the distributions of transport coefficients as well as the source profile. A convex solution of the inverse problem is retained which makes the calculations highly computational efficient. Moreover, this allows for the estimation of multi-dimensional transport coefficients, source terms, and in the future the analysis of the effect of regularization on experimental data and transport coefficient distributions.
Named entity recognition for Chinese based on global pointer and adversarial training
Authors: Li Hongjun , Cheng Mingzhe , Yang Zelin , Yang Liqun , Chua Yansong 
Published: February 2023

AbstractNamed entity recognition aims to identify entities from unstructured text and is an important subtask for natural language processing and building knowledge graphs. Most of the existing entity recognition methods use conditional random fields as label decoders or use pointer networks for entity recognition. However, when the number of tags is large, the computational cost of method based on conditional random fields is high and the problem of nested entities cannot be solved. The pointer network uses two modules to identify the first and the last of the entities separately, and a single module can only focus on the information of the first or the last of the entities, but cannot pay attention to the global information of the entities. In addition, the neural network model has the problem of local instability. To solve mentioned problems, a named entity recognition model based on global pointer and adversarial training is proposed. To obtain global entity information, global pointer is used to decode entity information, and rotary relative position information is considered in the model designing to improve the model’s perception of position; to solve the model’s local instability problem, adversarial training is used to improve the robustness and generalization of the model. The experimental results show that the F1 score of the model are improved on several public datasets of OntoNotes5, MSRA, Resume, and Weibo compared with the existing mainstream models.