bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroendocrine carcinoma of the minor papilla with pancreas divisum: a case report and review of the literature
Authors: Saito Kenta , Matsuo Yoichi , Denda Yuki , Nonoyama Keisuke , Murase Hiromichi , Kato Tomokatsu , Hayashi Yuichi , Imafuji Hiroyuki , Morimoto Mamoru , Ogawa Ryo , Takahashi Hiroki , Takiguchi Shuji 
Published: March 2023

Abstract
Background
Neuroendocrine tumors of the minor papilla are very rare, and only 20 cases have been reported in the literature. Neuroendocrine carcinoma of the minor papilla with pancreas divisum has not been reported previously, making this the first reported case. Neuroendocrine tumors of the minor papilla have been reported in association with pancreas divisum in about 50% of cases reported in the literature. We herein present our case of neuroendocrine carcinoma of the minor papilla with pancreas divisum in a 75-year-old male with a systematic literature review of the previous 20 reports of neuroendocrine tumors of the minor papilla.

Case presentation
A 75-year-old Asian man was referred to our hospital for evaluation of dilation of the main pancreatic duct noted on abdominal ultrasonography. Magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography showed a dilated dorsal pancreatic duct, which was not connected to the ventral pancreatic duct; however, it opened to the minor papilla, indicating pancreas divisum. The common bile duct had no communication with the pancreatic main duct and opened to the ampulla of Vater. A contrast-enhanced computed tomography scan showed a 12-mm hypervascular mass near the ampulla of Vater. Endoscopic ultrasonography showed a defined hypoechoic mass in the minor papilla with no invasion. The biopsies performed at the previous hospital found adenocarcinoma. The patient underwent a subtotal stomach-preserving pancreaticoduodenectomy. The pathological diagnosis was neuroendocrine carcinoma. At the 15-year follow-up visit, the patient was doing well with no evidence of tumor recurrence.

Conclusion
In our case, because the tumor was discovered during a medical check-up relatively early in the course of disease, the patient was doing well at the 15-year follow-up visit, with no evidence of tumor recurrence. Diagnosing a tumor of the minor papilla is very difficult because of the relatively small size and submucosal location. Carcinoids and endocrine cell micronests in the minor papilla occur more frequently than generally thought. It is very important to include neuroendocrine tumors of the minor papilla in the differential diagnosis of patients with recurrent pancreatitis or pancreatitis of unknown cause, especially for patients with pancreas divisum.
Broad snouted cladoselachian with sensory specialization at the base of modern chondrichthyans
Authors: Klug Christian , Coates Michael , Frey Linda , Greif Merle , Jobbins Melina , Pohle Alexander , Lagnaoui Abdelouahed , Haouz Wahiba Bel , Ginter Michal 
Published: March 2023

AbstractThroughout the Silurian and Devonian, cartilaginous fish successively evolved their specialized skeletal and dental characteristics, and increasingly refined their sensory systems. The Late Devonian shark taxon Maghriboselache mohamezanei gen. et sp. n. from the eastern Anti-Atlas of Morocco is known from multiple specimens preserving most of its skeletal features, which in some instances are preserved in three dimensions. Key details of the dentition, jaws, and pectoral skeleton are shared with the iconic genus Cladoselache. Phylogenetic analyses place the family Cladoselachidae as the sister group of symmoriiforms and these groups as sister group of the holocephalans. Further phylogenetic results corroborate that the initial evolutionary radiation of crown chondrichthyans occurred within or before the Late Devonian. Remarkably, this new stem holocephalan is equipped with a wide snout and large laterally separated nasal capsules: the earliest known example of this condition in the chondrichthyan and (perhaps) gnathostome record. This suggests sensory specialization approaching that of extant broad-rostrum elasmobranchs and represents a significant addition to increasingly apparent ecomorphological diversity among early chondrichthyans.ZooBank LSID: urn:lsid:zoobank.org:pub:85F45912-9EBA-4061-B62B-5937180E807A.
Retrospective study on the efficacy of monocyte distribution width (MDW) as a screening test for COVID-19
Authors: Wakamatsu Kentaro , Nagasawa Zenzo , Katsuki Kouta , Kumazoe Hiroyuki , Yasuda Masayo , Kawamoto Sae , Kawamura Ayano , Ueno Tsuyoshi , Kiyotani Ruriko , Fukui Izumi , Maki Sanae , Nagata Nobuhiko , Kawasaki Masayuki , Yamada Hozumi 
Published: March 2023

Abstract
Background
Pathogenic genetic testing for coronavirus disease 2019 (COVID-19) can detect viruses with high sensitivity; however, there are several challenges. In the prevention, testing, and treatment of COVID-19, more effective, safer, and convenient methods are desired. We evaluated the possibility of monocyte distribution width (MDW) as an infection biomarker in COVID-19 testing.

Methods
The efficacy of MDW as a screening test for COVID-19 was retrospectively assessed in 80 patients in the COVID-19 group and 232 patients in the non-COVID-19 group (141 patients with acute respiratory infection, 19 patients with nonrespiratory infection, one patient with a viral infection, 11 patients who had received treatment for COVID-19, one patient in contact with COVID-19 patients, and 59 patients with noninfectious disease).

Results
The median MDW in 80 patients in the COVID-19 group was 23.3 (17.2–33.6), and the median MDW in 232 patients in the non-COVID-19 group was 19.0 (13.6–30.2) (P < 0.001). When the COVID-19 group was identified using the MDW cut-off value of 21.3 from the non-COVID-19 group, the area under the curve (AUC) was 0.844, and the sensitivity and specificity were 81.3% and 78.2%, respectively. Comparison of MDW by severity between the COVID-19 group and patients with acute respiratory infection in the non-COVID-19 group showed that MDW was significantly higher in the COVID-19 group for all mild, moderate I, and moderate II disease.

Conclusions
MDW (cut-off value: 21.3) may be used as a screening test for COVID-19 in fever outpatients.
Trial registration This study was conducted after being approved by the ethics committee of National Hospital Organization Omuta National Hospital (Approval No. 3-19). This study can be accessed via https://omuta.hosp.go.jp/files/000179721.pdf.
Internet use, users, and cognition: on the cognitive relationships between Internet-based technology and Internet users
Authors: Nagam Vishruth M. 
Published: March 2023

Abstract
Background
This study aims to investigate growing Internet use in relation to memory and cognition. Though literature reveals human capability to utilize the Internet as a transactive memory source, the formational mechanisms of such transactive memory systems are not extensively explored. The Internet’s comparative effects on transactive memory and semantic memory are also relatively unknown.

Methods
This study comprises two experimental memory task survey phases utilizing null hypothesis and standard error tests to assess significance of results.

Results
When information is expected to be saved and accessible, recall rates are lower, regardless of explicit instructions to remember (Phase 1, N = 20). Phase 2 suggests the importance of order of attempted recall: depending on whether users first attempt to recall (1) desired information or (2) the information’s location, subsequent successful cognitive retrieval is more likely to occur for (1) only desired information or both desired information and location thereof or (2) only desired information’s location, respectively (N = 22).

Conclusions
This study yields several theoretical advances in memory research. The notion of information being saved online and accessible in the future negatively affects semantic memory. Phase 2 reveals an adaptive dynamic—(1) as Internet users often have a vague idea of desired information before searching for it on the Internet, first accessing semantic memory serves as an aid for subsequent transactive memory use and (2) if transactive memory access is successful, the need to retrieve desired information from semantic memory is inherently eliminated. By repeatedly defaulting to first accessing semantic memory and then transactive memory or to accessing transactive memory only, Internet users may form and reinforce transactive memory systems with the Internet, or may refrain from enhancing and decrease reliance on transactive memory systems by repeatedly defaulting to access only semantic memory; the formation and permanence of transactive memory systems are subject to users’ will. Future research spans the domains of psychology and philosophy.
Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications
Authors: Liu Shuai , Yu Jiang-Ming , Gan Yan-Chang , Qiu Xiao-Zhong , Gao Zhe-Chen , Wang Huan , Chen Shi-Xuan , Xiong Yuan , Liu Guo-Hui , Lin Si-En , McCarthy Alec , John Johnson V. , Wei Dai-Xu , Hou Hong-Hao 
Published: March 2023

AbstractBiomimetic materials have emerged as attractive and competitive alternatives for tissue engineering (TE) and regenerative medicine. In contrast to conventional biomaterials or synthetic materials, biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix (ECM). Additionally, such materials have mechanical adaptability, microstructure interconnectivity, and inherent bioactivity, making them ideal for the design of living implants for specific applications in TE and regenerative medicine. This paper provides an overview for recent progress of biomimetic natural biomaterials (BNBMs), including advances in their preparation, functionality, potential applications and future challenges. We highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ECM. Moreover, we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE applications. Finally, we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.
Choroidal structure investigated by choroidal vascularity index in patients with inherited retinal diseases
Authors: Bayat Kia , Hassanpour Kiana , Sabbaghi Hamideh , Fekri Sahba , Daftarian Narsis , Motevasseli Tahmineh , Suri Fatemeh , Kheiri Bahareh , Yaseri Mehdi , Ahmadieh Hamid 
Published: March 2023

Abstract
Purpose
To evaluate the choroidal structure in patients with inherited retinal diseases (IRDs) by investigating the choroidal vascularity index (CVI).

Methods
The present study was conducted on 113 IRD patients and 113 sex- and age-matched healthy individuals. Patients’ data was extracted from the Iranian National Registry for IRDs (IRDReg®). Total choroidal area (TCA) was determined between retinal pigment epithelium and choroid-scleral junction,1500 microns on either side of the fovea. Luminal area (LA) was considered as the black area corresponding to the choroidal vascular spaces, following Niblack binarization. CVI was calculated as the ratio of the LA to the TCA. CVI and other parameters were compared among different types of IRD and the control group.

Results
The IRD diagnosis included retinitis pigmentosa (n = 69), cone-rod dystrophy (n = 15), Usher syndrome (n = 15), Leber congenital amaurosis (n = 9), and Stargardt disease (n = 5). Sixty-one (54.0%) individuals of each of the study and control groups were male. The average CVI was 0.65 ± 0.06 in the IRD patients and 0.70 ± 0.06 in the control group (P < 0.001). Accordingly, the average of TCA and LA were 2.32 ± 0.63 and 1.52 ± 0.44 mm [1] in patients with IRDs, respectively. The measurements for the TCA and the LA were significantly lower in all subtypes of IRD (P-values < 0.05).

Conclusion
CVI is significantly lower in patients with IRD than in healthy age-matched individuals. Choroidal changes in IRDs may be related to the changes in the lumen of the choroidal vessels rather than the stromal changes.
Do dietary habits affect the premenstrual syndrome severity among a cohort of Egyptian females? A cross-sectional study
Authors: Helmy Nisreen A. , Kamel Dalia M. , Gabr Amir A. , Shehata Mai M. A. 
Published: March 2023

Abstract
Background
Premenstrual syndrome (PMS) is considered a common recurring emotional as well as physical disorder which has an effect on the women’s quality of life. Results of previous studies about the relationship between PMS and food intake are contradicted. The purpose of this study was to investigate the relationship between the PMS and food consumption in menstrual females. The study was carried out in the Outpatient Physiotherapy Department Clinic in Cairo University, Giza, Egypt. The study was carried out from October 2021 to March 2022. One-hundred participants that were having PMS enrolled into this study (n = 100) with a mean age of 27.1 ± 4.98 and a mean BMI of 26.4 ± 4.5. The PMS scale was used to assess the degree of PMS, and a food frequency questionnaire (FFQ) was applied to evaluate the food consumption.

Results
A total of 16% of females had mild PMS, 60% had moderate, and 24% had severe PMS. There was a significant relationship between PMS severity and specific food consumption as consumption of tubers as well as fish and seafood (p = 0.03 & p = 0.008, respectively). There was a significant inverse correlation between PMS severity and the fish and seafood consumption, while there was no significant correlation between the PMS severity and tuber consumption. However, there was no significant relationship between PMS and grains, dairy products, caffeine intake, fat intake, sweets, vegetables, fruits, seasonings, and pickles.

Conclusion
The present study suggested that severity of PMS might be affected by specific dietary habits. Therefore, further studies are needed to investigate the relationship between PMS and amount of food consumption.
Vibration response analysis of footbridge based on pedestrian perception
Authors: Feng Yuhao , Chen Deyi , Wang Zhenyu , Huang Shiping , He Yuejie 
Published: March 2023

AbstractThis article aims to study the influence of random crowd loading on the perceived vibration response of pedestrians. Firstly, a vertical vibration response analysis method considering pedestrian perception was established based on the random crowd walking model. Secondly, change rules of maximum vibration response of pedestrians, occurrence time and position interval under different random walk models were compared and analyzed. Finally, the vibration response reduction factor was defined by studying the correlation between the maximum vibration response of pedestrians and the peak acceleration of the structure, and the approximate calculation method of the maximum vibration response of pedestrians was proposed. The results show that the maximum acceleration perceived by pedestrians obeys the normal distribution under the four crowd walking models, the response distribution of ordered arrangement model (OAM) is larger than that of the other three models; The location and occurrence time of the maximum response depend on the distribution of pedestrian locations on the footbridge, and there is no significant change with the increase of population density. In addition, the distribution of OAM and stochastic arrival model (SAM) are consistent, which is concentrated in the middle of the total time-history. In contrast, the distribution of stochastic distribution model (SDM) and dynamic equilibrium model (DEM) are relatively uniform. The maximum error between the calculated acceleration maximum value and the actual acceleration value felt by the pedestrian is less than 5%. These results can provide reference for quantitative evaluation of pedestrian-induced vibration comfort.
Cardiorespiratory Fitness in Young Adult Women With a History of Premature Adrenarche
Authors: Tennilä Jussi , Jääskeläinen Jarmo , Utriainen Pauliina , Voutilainen Raimo , Laitinen Tomi , Liimatta Jani 
Published: March 2023

AbstractContextPremature adrenarche (PA) may predispose to some adverse long-term health outcomes. Cardiorespiratory fitness (CRF) is one of the strongest factors known to predict overall health, but no data exist on the CRF of women with a history of PA.ObjectiveTo study if hyperandrogenism in childhood resulting from PA leads to a measurable difference in CRF between young adult PA and control women.MethodsA total of 25 women with PA and 36 age-matched controls were followed from prepubertal age until adulthood. Anthropometric measurements, body composition, biochemical, and lifestyle factors were assessed. The main outcome measure was maximal cycle ergometer test result at the mean age of 18.5 years. We also assessed prepubertal predicting factors for CRF with different linear regression models.ResultsThough prepubertal children with PA were taller and heavier than their non-PA peers, there were no significant differences in height, body mass index, body composition, or physical activity in young adulthood. We observed no significant differences in any of the parameters of the maximal cycle ergometer test, including maximal load (P = .194) or peak oxygen consumption (P = .340). Hemodynamic responses of the groups were similar. None of the examined models or prepubertal factors significantly predicted CRF at adult age.ConclusionThis study suggests that hyperandrogenism in childhood/adolescence resulting from PA does not have a significant impact on adulthood CRF.
Bilateral Low-Frequency Hearing Impairment After Microvascular Decompression Surgery
Authors: Ujihara Masaki , Kobayashi Masahito , Hirata Sachiko , Takabatake Kazuhiko , Wakiya Kenji , Fujimaki Takamitsu 
Published: March 2023

BACKGROUND:
Hearing impairment is an important complication of microvascular decompression (MVD). In patients after MVD, we have occasionally noted slight to moderate hearing deterioration at low frequencies that is difficult to detect using pure tone average.

OBJECTIVE:
To assess the incidence and features of low-frequency hearing impairment (LF-HI) after MVD and evaluate its associated factors.

METHODS:
This single-center, retrospective observational study assessed the audiometric outcome of 270 patients who underwent MVD between January 2015 and December 2020. Preoperative and postoperative hearing levels were compared for each frequency. LF-HI was defined as a hearing deterioration of ≥15 dB at 125, 250, or 500 Hz. The incidence, symptoms, and associated factors of LF-HI were analyzed.

RESULTS:
Statistical analysis of the patients overall demonstrated slight but significant decreases in the hearing level after MVD at lower frequencies on both the operative and contralateral sides. Eighty-one patients (30.0%) had LF-HI: 49 on the operative side, 24 on the contralateral side, and 8 on both sides, while pure tone average was worsened in 5 patients (1.8%). Subjective symptoms, including hearing deterioration, ear fullness, tinnitus, and dizziness, developed in 10.4% of the patients with LF-HI but improved subsequently within several weeks. “Older age” and “operative side” were associated with LF-HI.

CONCLUSION:
Decreases in lower-frequency hearing levels in both the ipsilateral and contralateral (nonoperative) ears were observed after trigeminal neuralgia and hemifacial spasm surgery. LF-HI does not cause permanent symptoms but may be a noteworthy phenomenon, possibly involved in the contralateral hearing loss encountered occasionally after other types of posterior cranial fossa surgery.
A conserved role of the Hippo signalling pathway in initiation of the first lineage specification event across mammals
Authors: Gerri Claudia , McCarthy Afshan , Mei Scott Gwen , Regin Marius , Stamatiadis Panagiotis , Brumm Sophie , Simon Claire S. , Lee Janet , Montesinos Cristina , Hassitt Caroline , Hockenhull Sarah , Hampshire Daniel , Elder Kay , Snell Phil , Christie Leila , Fouladi-Nashta Ali A. , Van de Velde Hilde , Niakan Kathy K. 
Published: March 2023

ABSTRACT
Our understanding of the molecular events driving cell specification in early mammalian development relies mainly on mouse studies, and it remains unclear whether these mechanisms are conserved across mammals, including humans. We have shown that the establishment of cell polarity via aPKC is a conserved event in the initiation of the trophectoderm (TE) placental programme in mouse, cow and human embryos. However, the mechanisms transducing cell polarity into cell fate in cow and human embryos are unknown. Here, we have examined the evolutionary conservation of Hippo signalling, which is thought to function downstream of aPKC activity, in four different mammalian species: mouse, rat, cow and human. In all four species, inhibition of the Hippo pathway by targeting LATS kinases is sufficient to drive ectopic TE initiation and downregulation of SOX2. However, the timing and localisation of molecular markers differ across species, with rat embryos more closely recapitulating human and cow developmental dynamics, compared with the mouse. Our comparative embryology approach uncovered intriguing differences as well as similarities in a fundamental developmental process among mammals, reinforcing the importance of cross-species investigations.
Spastin is an essential regulator of male meiosis, acrosome formation, manchette structure and nuclear integrity
Authors: Cheers Samuel R. , O'Connor Anne E. , Johnson Travis K. , Merriner D. Jo , O'Bryan Moira K. , Dunleavy Jessica E. M. 
Published: March 2023

ABSTRACT
The development and function of male gametes is dependent on a dynamic microtubule network, yet how this is regulated remains poorly understood. We have recently shown that microtubule severing, via the action of the meiotic AAA ATPase protein clade, plays a crucial role in this process. Here, we sought to elucidate the roles of spastin, an as-yet-unexplored member of this clade in spermatogenesis. Using a SpastKO/KO mouse model, we reveal that spastin loss resulted in a complete loss of functional germ cells. Spastin plays a crucial role in the assembly and function of the male meiotic spindle. Consistent with meiotic failure, round spermatid nuclei were enlarged, indicating aneuploidy, but were still able to enter spermiogenesis. During spermiogenesis, we observed extreme abnormalities in manchette structure, acrosome biogenesis and, commonly, a catastrophic loss of nuclear integrity. This work defines an essential role for spastin in regulating microtubule dynamics during spermatogenesis, and is of potential relevance to individuals carrying spastin variants and to the medically assisted reproductive technology industry.