bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rapid HPV typing assay to support global cervical cancer screening and risk‐based management: A cross‐sectional study
Authors: Inturrisi Federica , de Sanjosé Silvia , Desai Kanan T. , Dagnall Casey , Egemen Didem , Befano Brian , Rodriguez Ana Cecilia , Jeronimo Jose A. , Zuna Rosemary E. , Hoffman Amanda , Farhat Nozzari Sepideh , Walker Joan L. , Perkins Rebecca B. , Wentzensen Nicolas , Palefsky Joel M. , Schiffman Mark 
Published: September 2023

AbstractThe World Health Organization recommends human papillomavirus (HPV) testing for cervical screening. Extended genotyping can identify the highest‐risk HPV‐positive women. An inexpensive, rapid, mobile isothermal amplification assay (ScreenFire HPV RS test) was recently redesigned to yield four channels ordered by cancer risk (ie, hierarchical approach): HPV16, HPV18/45, HPV31/33/35/52/58 and HPV39/51/56/59/68. Stored specimens from 2076 women (mean age 30.9) enrolled in a colposcopy clinic, with high HPV prevalence, were tested with ScreenFire. We calculated hierarchical channel positivity and non‐hierarchical channel and type positivity, according to histologic diagnosis (256 cancer, 350 cervical intraepithelial neoplasia [CIN]3, 409 CIN2, 1020 < CIN2) and known virologic reference results (Linear Array and TypeSeq). Additionally, we analyzed ScreenFire time‐to‐positive up to 60 min by channel and histology. Overall clinical sensitivity for CIN3+ was 94.7% (95% confidence interval 92.6‐96.4), similar to Linear Array (92.3, 89.7‐94.3) and TypeSeq (96.0, 93.9‐97.6). Sensitivity was high for all types and channels. The hierarchical approach was well in line with HPV typing and histologic diagnosis, prioritizing higher risk women having HPV16 and precancer. For HPV16, time‐to‐positive was shorter in women with precancer. ScreenFire showed excellent agreement with research reference typing tests and detection of CIN2+. Risk‐based type results could help guide clinical management of HPV‐positive women. Time‐to‐positive combined with genotyping might be useful. ScreenFire is rapid, mobile, relatively inexpensive and designed for implementation of HPV‐based screening and management, including in lower‐resource settings. Further validation in screening by self‐sampling and practical effectiveness merit evaluation.
Training individuals to implement discrete‐trial teaching procedures using behavioral skills training: A scoping review with implications for practice and research
Authors: Briggs Adam M. , Zohr Samantha J. , Harvey Olivia B. 
Published: September 2023

AbstractBehavioral skills training (BST) is an evidence‐based approach for training individuals to implement discrete‐trial teaching procedures. Despite the effectiveness of this approach, implementing BST can be time and resource intensive, which may interfere with a clinical organization's adoption of this training format. We conducted a scoping review of studies using BST components for training discrete‐trial teaching procedures in peer‐reviewed articles between 1977 and 2021. We identified 51 studies in 46 publications involving 354 participants. We coded descriptive data on (a) participant characteristics, (b) study characteristics, (c) training conditions (including instructions, modeling, rehearsal, and feedback), and (d) training outcomes. The results indicated that studies have primarily attempted to improve the efficacy and efficiency of BST by modifying or omitting common training components. We provide best‐practice considerations for using BST to teach discrete‐trial teaching procedures and offer a research agenda to guide future investigation in this area.
Increased Risk of Tooth Loss in Postmenopausal Women With Prevalent Vertebral Fractures: An Observational Study
Authors: Taguchi Akira , Urano Tomohiko , Nakamura Yukio , Shiraki Masataka 
Published: September 2023

ABSTRACTThe association between prevalent fractures and tooth loss in postmenopausal women remains unclear. Herein, we investigated the association between prevalent vertebral and nonvertebral fractures, the number of teeth present at baseline, and the number of teeth lost during follow‐up in postmenopausal Japanese women. This cross‐sectional study enrolled 843 participants (mean age 68.3 years). The number of teeth at follow‐up was evaluated in 655 women in this longitudinal study. The participants were divided into four groups according to their prevalent fracture status: no fractures, vertebral fractures alone, nonvertebral fractures alone, and both fracture types. After adjusting for covariates, Poisson regression analyses were performed to investigate differences in the number of teeth at baseline and that lost during the follow‐up period among the four groups. Participants with prevalent vertebral fractures alone had significantly fewer teeth at baseline than those in participants without fractures or nonvertebral fractures alone (p < 0.001 for both). Furthermore, they lost more teeth during the follow‐up period than did those with no fractures (p = 0.021) and tended to lose more teeth than did those with nonvertebral fractures alone or both prevalent fracture types. We observed no significant difference in the number of teeth lost between the participants with nonvertebral fractures alone and those with no fractures. Postmenopausal women with prevalent vertebral fractures may be at a higher risk of tooth loss. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Contextual Constraining of Student Design Practices
Authors: Goncher Andrea , Johri Aditya 
Published: September 2023

AbstractBackgroundEngineering design is of significant interest to engineering educators. As yet, how the higher education context shapes student outcomes in engineering design courses remains underexplored. Since design courses are the primary way students are taught the critical topic of design, it is important to understand how the institutional and organizational contexts shape student outcomes and how we could improve design projects, given the context.PurposeWe sought to answer two questions: What aspects of the design education process are salient, or important, for students? How do these salient aspects affect their design practices?Design/MethodWe used a qualitative case study approach to address the research questions because of our emphasis on understanding process‐related aspects of design work and developing an interpretive understanding from the students’ perspective.ResultsUsing a nested structuration framework, we show that the context of design practices shaped students’ outcomes by constraining their approach to the project and by providing a framework for their design process. We provide recommendations for design educators to help students overcome impediments to achieving learning objectives for design activities. Our research questions the efficacy of teaching engineering design when a design problem lacks a context beyond the classroom.ConclusionsThe institutional and organizational contexts influence student design practices. Engineering educators should carefully consider the potential effects of the design projects they implement within a higher education context.
Midline catheters in patients with advanced chronic kidney disease
Authors: Paje David , Heath Megan , Heung Michael , Horowitz Jennifer K. , Bernstein Steven J. , Flanders Scott A. , Chopra Vineet 
Published: September 2023

AbstractBackgroundMidline catheters (midlines) are increasingly used in patients with advanced chronic kidney disease (CKD).ObjectiveThis study describes current practice and acute complications associated with midlines in CKD patients.Designs, Setting, and ParticipantsTrained abstractors at 66 hospitals from the Michigan Hospital Medicine Safety (HMS) Consortium collected data on a sample of patients who received a midline during hospitalization. Patients were classified as having advanced CKD if their estimated glomerular filtration rate was <45 mL/min/1.73 m2.Main Outcome and MeasuresMidline recipients with advanced CKD were compared to those without advanced CKD by patient, provider, and device characteristics, and by the occurrence of acute complications including major (e.g., upper extremity deep vein thrombosis [UE‐DVT] and catheter‐related bloodstream infection [CRBSI]) or minor (e.g., catheter occlusion, catheter dislodgement, infiltration, superficial thrombophlebitis, and leaking at insertion site) events. Multivariable mixed effects logistic regression was used to evaluate the association between catheter‐related complications and stage of CKD.ResultsOf 21,415 midline recipients, 5272 (24.6%) had advanced CKD, while 16,143 (75.4%) did not. Most midlines were single lumen (90.5%) and remained in place for a median of 6 days. A major or minor midline complication occurred in 804 (15.3%) patients with and 2239 (14.4%) patients without advanced CKD (adjusted odds ratios = 1.04; 95% confidence interval: 0.94–1.14). Among patients with advanced CKD, CRBSI occurred in 13 patients (0.2%) and UE‐DVT occurred in 65 patients (1.2%). The proportion of advanced CKD among midline recipients and the frequency of midline‐related complications varied across hospitals (interquartile range [IQR] = 19.2% to 29.8% [median = 25.0%] and IQR = 11.0%–18.9% [median = 15.4%], respectively).
Mpox in Northeast Brazil: Spatiotemporal analysis and predictors associated with confirmed diagnosis
Authors: Silva Júnior José Valter J. , de Souza Carlos Dornels Freire , Flores Eduardo Furtado , Weiblen Rudi , do Carmo Rodrigo Feliciano 
Published: September 2023

AbstractThe mpox outbreaks reported in several countries from May 2022 have shown an epidemiological profile different from that observed in previous years, raising a global public health alert. This issue is particularly important for Brazil, the second country with the highest number of mpox cases. Herein, we performed a retrospective cross‐sectional study on mpox cases notified in Pernambuco state, northeastern Brazil, between July 2022 and March 2023. Confirmed mpox cases were analyzed in a space‐time series and their social and clinical characteristics were compared with those of suspect‐negative cases, including a multivariate logistic regression to identify predictors associated with a positive diagnosis. A total of 1493 suspected mpox cases were reported, of which 362 cases (24.2%) were confirmed and distributed in 33 municipalities. Most mpox cases occurred between epidemiological weeks (EW) 33 and 39 of 2022, with the highest moving average in EW 34 and 35 (36 and 31.5, respectively). The most frequent clinical signs and symptoms were rash (87.3%), fever (60.2%), headache (45.3%), and genital/perianal lesions (40.3%). In the multivariate analysis, three variables showed considerable performance in predicting a positive mpox diagnosis (area under the ROC curve = 0.87; 95% CI: 0.84−0.90): sexual orientation (nonheterosexual; OR: 23.08; 95% CI: 13.97−38.15), male sex (OR: 2.05; 95% CI: 1.10−3.85), and multiple partnerships (OR: 1.95; 95% CI: 1.15−3.32). Overall, in addition to the detailed spatiotemporal description of mpox cases, which may contribute to appropriate public health measures, our study brings insights into mpox epidemiology by describing predictors associated with a positive diagnosis.
The social self in humanistic counseling: A dialogical alternative for the practice of wellness and social justice
Authors: Lemberger‐Truelove Matthew E. , Lazzareschi Nicholas R. , Godhwani Tara , Warwick Lindsey A. 
Published: September 2023

AbstractClassical humanistic philosophy and psychology both infer the persistence of a stable, authentic, and volitional self, which neither fully coheres with the values implicit to professional counseling nor offers sufficient relevance to culturally diverse client groups. As an alternative, the authors suggest that humanistic counseling can emerge as a distinct discipline of practice independent of its early influences. Further, the authors offer a dialogical alternative for humanistic counseling practice that might better support contemporary clients and their various social determinants of experience.
The ZooScan and the ZooCAM zooplankton imaging systems are intercomparable: A benchmark on the Bay of Biscay zooplankton
Authors: Grandremy Nina , Dupuy Christine , Petitgas Pierre , Mestre Sophie Le , Bourriau Paul , Nowaczyk Antoine , Forest Bertrand , Romagnan Jean‐Baptiste 
Published: September 2023

ABSTRACTZooplankton analysis represents a bottleneck in marine ecology studies due to the difficulty to obtain zooplankton data. The last decades have seen the intense development of zooplankton imaging systems, to increase the zooplankton data spatio‐temporal resolution as well as enabling the combination of size, taxonomy, and functional traits in aquatic ecology studies. Here, we propose a benchmark between the ZooScan, a commercially available, laboratory‐based scanner, which analyses zooplankton preserved samples, and the ZooCAM, an in‐flow imaging system designed for on‐board live zooplankton imaging. Sixty‐one zooplankton samples collected over the Bay of Biscay in environments ranging from estuarine to offshore blue waters were imaged with both instruments. Zooplankton Normalized Biovolume‐Size Spectra slopes, mean sizes, abundances, and zooplankton community biogeographical patterns were computed for each instrument and compared at the taxonomic group, the sampling stations and the Bay of Biscay scales. Both instruments produced similar zooplankton variables by stations and by taxa and described similar zooplankton community compositions and biogeographical patterns, on the large mesozooplankton size range, i.e., [0.3–3.39] mm ESD. We conclude that the ZooCAM and the ZooScan data can be combined to generate long term or spatially resolved zooplankton time series. Our study shows that benchmarking imaging instruments or techniques (1) offers a robust assessment of interoperability between instruments, mitigating possible instrumental biases, and (2) may be of great interest in the case of instrumental obsolescence or breakdown, to choose the most conservative replacement solution in a long term time series framework.
Reactive Oxygen Species (ROS)‐Assisted Nano‐Therapeutics Surface‐Decorated with Epidermal Growth Factor Fragments for Enhanced Wound Healing
Authors: Lee Miso , Bui Hoai‐Thuong Duc , Pham Lan , Kim Songrae , Yoo Hyuk Sang 
Published: September 2023

AbstractIn this study, stimuli‐responsive liberation of an epidermal growth factor fragment (EGFfr) is accomplished using nanofibrous meshes to improve wound healing effects. Electrospun nanofibers are fragmented by mechanical milling, followed by aminolysis to fabricate powdered nanofibrils (NFs). EGFfrs are covalently immobilized on NFs via thioketal linkers (EGFfr@TK@NF) for reactive oxygen species (ROS)–dependent liberation. EGFfr@TK@NF exhibits ROS‐responsive liberation of EGFfr from the matrix at hydrogen peroxide (H2O2) concentrations of 0–250 mm. Released EGFfr is confirmed to enhance the migration of HaCaT cell monolayers, and keratinocytic gene expression levels are significantly enhanced when H2O2 is added to obtain the released fraction of NFs. An in vivo study on the dorsal wounds of mice reveals that EGFfr‐immobilized NFs improve the expression levels of keratin1, 5, and 14 for 2 weeks when H2O2 is added to the wound sites, suggesting that the wounded skin is re‐epithelized with the original epidermis. Thus, EGFfrs‐immobilized NFs are anticipated to be potential nanotherapeutics for wound treatment in combination with the conventional disinfection process with H2O2.
Insights into Entropy Change of β2 Relaxation in Retraction of Uniaxially Stretched Polyimide Films
Authors: Jiang Tian , Hu Wende , Cui Jing , Liu Jingni , Sun Xuyang , Zhang Peibin , Wang Chuanming , Li Yingcheng 
Published: September 2023

AbstractStretching has been extensively applied for decades in the production of polyimide (PI) materials with improved mechanical, electrical, and thermal properties. Meanwhile, a detailed understanding of the molecular motions during stretching is still limited. Herein, the thermomechanical behaviors of uniaxially stretched PI films prepared from 3,3′,4,4′‐biphenyl tetracarboxylic dianhydride (BPDA) and 2,2′‐bis (trifluoromethyl) benzidine (TFDB) are studied, and the possible molecular motions responsible for the sub‐glass transition temperature (Tg) stretchability and retraction after stretching are systematically investigated. Based on X‐ray diffraction and dynamic mechanical analysis, it is revealed that both the sub‐Tg stretchability and retraction correlates with β2 relaxation, which originates from the highly cooperative molecular motions of conformational rotations involving segmented BPDA units. A thermodynamic model is established and applied for the analysis of the retraction behaviors of stretched BPDA‐TFDB PI films. It is found that the increase of entropy under stretching plays a significant role in most retraction cases. However, as the stretching temperature increases, the α relaxation‐correlated large‐scale molecular motions emerge. Such motions partially counterbalance the conformational rotations of BPDA segments, leading to an enhanced contribution of enthalpy decrease during the retraction of BPDA‐TFDB PI films.
Pain in Multiple System Atrophy a Systematic Review and Meta‐Analysis
Authors: Campese Nicole , Caliò Bianca , Leys Fabian , Kaltenbach Lalit , Göbel Georg , Wanschitz Julia , Schlager Andreas , Zamarian Laura , Bannister Kirsty , Chaudhuri Ray K. , Schrag Anette , Granata Roberta , Kiechl Stefan , Poewe Werner , Seppi Klaus , Wenning Gregor , Fanciulli Alessandra 
Published: September 2023

AbstractBackgroundIndividuals with multiple system atrophy (MSA) often complain about pain, nonetheless this remains a poorly investigated non‐motor feature of MSA.ObjectivesHere, we aimed at assessing the prevalence, characteristics, and risk factors for pain in individuals with MSA.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta‐Analyzes (PRISMA) guidelines, we systematically screened the PubMED, Cochrane, and Web of Science databases for papers published in English until September 30, 2022, combining the following keywords: “pain,” “multiple system atrophy,” “MSA,” “olivopontocerebellar atrophy,” “OPCA,” “striatonigral degeneration,” “SND,” “Shy Drager,” and “atypical parkinsonism.”ResultsThe search identified 700 records. Sixteen studies provided information on pain prevalence in cohorts of MSA individuals and were included in a qualitative assessment based on the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. Thirteen studies (11 cross‐sectional, two longitudinal) scored ≥14 points on QUADAS assessment and were included in a quantitative analysis, pooling data from 1236 MSA individuals. The resulting pooled prevalence of pain in MSA was 67% (95% confidence intervals [CI] = 57%–75%), and significantly higher in individuals with MSA of parkinsonian rather than cerebellar type (76% [95% CI = 63%–87%] vs. 45% [95% CI = 33%–57%], P = 0.001). Pain assessment tools and collected information were highly heterogeneous across studies. Two studies reported pain treatment strategies and found that only every second person with MSA complaining about pain had received targeted treatment.ConclusionsWe found that pain is a frequent, but still under‐recognized and undertreated feature of MSA. Further research is needed to improve pain detection and treatment in MSA.
Diffusion‐weighted SPECIAL improves the detection of J‐coupled metabolites at ultrahigh magnetic field
Authors: Mosso Jessie , Simicic Dunja , Lanz Bernard , Gruetter Rolf , Cudalbu Cristina 
Published: September 2023

AbstractPurposeTo improve the detection and subsequent estimation of the diffusion properties of strongly J‐coupled metabolites in diffusion‐weighted MRS (DWS).MethodsA new sequence for single‐voxel diffusion‐weighted 1H MR spectroscopy, named DW‐SPECIAL, is proposed. It combines the semi‐adiabatic SPECIAL sequence with a stimulated echo diffusion block. Acquisitions with DW‐SPECIAL and STE‐LASER, the current gold standard for rodent DWS experiments at high fields, were performed at 14.1T on phantoms and in vivo on the rat brain. The apparent diffusion coefficient and intra‐stick diffusivity (Callaghan's model, randomly‐oriented sticks) were fitted and compared between the sequences for glutamate, glutamine, myo‐inositol, taurine, total NAA, total Cho, total Cr, and the macromolecules.ResultsThe shorter TE achieved with DW‐SPECIAL (18 ms against 33 ms with STE‐LASER) substantially limited the metabolites' signal loss caused by J‐evolution. In addition, DW‐SPECIAL preserved the main advantages of STE‐LASER: absence of cross‐terms, diffusion time during a stimulated echo, and limited sensitivity to B1 inhomogeneities. In vivo, compared to STE‐LASER, DW‐SPECIAL yielded the same spectral quality and reduced the Cramer Rao Lower Bounds for J‐coupled metabolites, irrespective of the b‐value. DW‐SPECIAL also reduced the SD of the metabolites' diffusion estimates based on individual animal fitting without loss of accuracy compared to the fit on the averaged decay.ConclusionWe conclude that due to its reduced TE, DW‐SPECIAL can serve as an alternative to STE‐LASER when strongly J‐coupled metabolites like glutamine are investigated, thereby extending the range of accessible metabolites in the context of DWS acquisitions.
Prospective motion correction for cervical spinal cord MRS
Authors: Adanyeguh Isaac M. , Henry Pierre‐Gilles , Deelchand Dinesh K. 
Published: September 2023

AbstractPurposeTo develop prospective motion correction for single‐voxel MRS in the human cervical spinal cord.MethodsA motion MR navigator was implemented using reduced field‐of‐view 2D‐selective RF excitation together with EPI readout. A short‐echo semi‐LASER sequence (TE = 30 ms) was updated to incorporate this real‐time image‐based motion navigator, as well as real‐time shim and frequency navigators. Five healthy participants were studied at 3 T with a 64‐channel head–neck receive coil. Single‐voxel MRS data were measured in a voxel located at the C3‐5 vertebrae level. The motion navigator was used to correct for translations in the X‐Y plane and was validated by assessing spectral quality with and without prospective correction in the presence of subject motion.ResultsWithout prospective correction, motion resulted in severe lipid contamination in the MR spectra. With prospective correction, the quality of spinal cord MR spectra in the presence of motion was similar to that obtained in the absence of motion, with comparable spectral signal‐to‐noise ratio and linewidth and no significant lipid contamination.ConclusionProspective motion and B0 correction allow acquisition of good‐quality MR spectra in the human cervical spinal cord in the presence of motion. This new technique should facilitate reliable acquisition of spinal cord MR spectra in both research and clinical settings.