bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postural control among individuals with and without chronic obstructive pulmonary disease: A cross-sectional study of motor and sensory systems
Authors: Strandkvist Viktor , Lindberg Anne , Larsson Agneta , Pauelsen Mascha , Stridsman Caroline , Nyberg Lars , Backman Helena , Röijezon Ulrik 
Published: April 2023

Background
Chronic obstructive pulmonary disease (COPD) is considered a heterogenic syndrome with systemic effects, including muscle dysfunction. There is evidence of postural control impairments among individuals with COPD, partly related to muscle weakness. However, research is scarce regarding the other underlying systems of postural control, such as the visual, somatosensory and vestibular system. The aim was to compare postural control, as well as the motor and sensory systems, between individuals with and without COPD.

Methods
Twenty-two participants with COPD (mean age 74.0 ±6.2 years) and 34 non-obstructive references (mean age 74.9 ±4.9 years) participated in this cross-sectional study. Postural control was assessed with center of pressure trajectory of postural sway in quiet as well as a limits of stability test, calculating mediolateral and anteroposterior amplitudes for each test. Assessment of function in the motor system included maximum hand grip strength, as well as maximum strength in muscles around the hip, knee and ankle joints. Visual acuity, pressure sensibility, proprioception, vestibular screening, and reaction time were also included. Data was compared between groups, and significant differences in postural control were further analyzed with an orthogonal projection of latent structures regression model.

Results
There was a significantly increased sway amplitude in the mediolateral direction in quiet stance on soft surface with eyes open (p = 0.014) as well as a smaller anteroposterior amplitude in the limits of stability test (p = 0.019) in the COPD group. Regression models revealed that the mediolateral amplitude was related to visual acuity and the burden of tobacco smoking assessed as pack-years. Further, muscle strength associated with anteroposterior amplitude in limits of stability test in the COPD group, and with age and ankle dorsal flexion strength among the referents. Besides for lower ankle plantar flexion strength in the COPD group, there were however no significant differences in muscle strength.

Conclusions
Individuals with COPD had a decreased postural control and several factors were associated with the impairments. The findings imply that the burden of tobacco smoking and reduced visual acuity relate to increased postural sway in quiet stance, and that muscle weakness is related to decreased limits of stability, among individuals with COPD.
Premature senescence of the liver in Alagille patients
Authors: Jannone Giulia , de Magnée Catherine , Tambucci Roberto , Evraerts Jonathan , Ravau Joachim , Najimi Mustapha , Sokal Etienne Marc 
Published: April 2023

Introduction
Alagille syndrome (ALGS) is an autosomal dominant disease characterized by a multisystem involvement including bile duct paucity and cholestasis, caused by JAG1 or NOTCH2 mutations in most of the cases. Jagged1-Notch2 interactions are known to be crucial for intrahepatic biliary tract development, but the Notch signaling pathway is also involved in the juxtacrine transmission of senescence and in the induction and modulation of the senescence-associated secretory phenotype (SASP).

Aim
Our aim was to investigate premature senescence and SASP in ALGS livers.

Methods
Liver tissue from ALGS patients was prospectively obtained at the time of liver transplantation (n = 5) and compared to control livers (n = 5).

Results
We evidenced advanced premature senescence in the livers of five JAG1 mutated ALGS pediatric patients through increased senescence-associated beta-galactosidase activity (p<0.05), increased p16 and p21 gene expression (p<0.01), and increased p16 and γH2AX protein expression (p<0.01). Senescence was located in hepatocytes of the whole liver parenchyma as well as in remaining bile ducts. The classical SASP markers TGF-β1, IL-6, and IL-8 were not overexpressed in the livers of our patients.

Conclusions
We demonstrate for the first time that ALGS livers display important premature senescence despite Jagged1 mutation, underlying the complexity of senescence and SASP development pathways.
Blood flow in the optic nerve head in patients with primary aldosteronism
Authors: Hirooka Kazuyuki , Oki Kenji , Ogawa-Ochiai Keiko , Nakaniida Yuta , Onoe Hiromitsu , Kiuchi Yoshiaki 
Published: April 2023

Purpose
Optic nerve head (ONH) blood flow decrease without changes in intraocular pressure in a possible rat model of retinal ganglion cell loss by systemic administration of aldosterone. To compare the blood flow in the ONH, using laser speckle flowgraphy (LSFG), in healthy eyes and in eyes with primary aldosteronism (PA).

Methods
The ONH tissue area mean blur rate (MT) was evaluated in this single center, retrospective, cross-sectional study using LSFG. In order to compare the MT between PA patients and normal subjects, mixed-effects models were used, with adjustments made for the mean arterial pressure, disc area, and β-peripapillary atrophy (β-PPA) area. Mixed-effects models were also used to analyze the risk factors affecting the MT.

Results
This study evaluated a total of 29 eyes of 17 PA patients and 61 eyes of 61 normal subjects. There was a significantly lower MT in PA patients (10.8 ± 0.4) as compared to the normal subjects (12.3 ± 0.3) (P = 0.004). The MT was significantly lower in PA patients (10.8 ± 0.6) even after adjusting for the potential confounding factors when compared to normal subjects (12.3 ± 0.3) (P = 0.046). Multivariate mixed-effects model analysis demonstrated that the MT was significantly associated with the PA and β-PPA.

Conclusions
There was a significantly lower ONH blood flow in PA patients as compared to normal subjects.
Corporate Governance Mechanisms, Profitability, Company Size and Tax Avoidance
Authors: Andriani Novia , Haryono Slamet 
Published: April 2023

Purpose: This research examines the impact of corporate governance mechanisms, profitability, and company size on tax avoidance.
Methodology: This research uses multiple regression analysis and an independent sample t-test. Based on a sample of 380 firm-year observations from 95 manufacturing companies listed on the List of Sharia-Compliant Securities in Indonesia and Malaysia in 2015-2018.
Findings: The results of this research concludes that independent of the boards, audit committees, audit quality, institutional ownership and managerial compensation had negative influences on tax avoidance. Profitability and company size had positive influences on tax avoidance. This research also finds differences in the level of tax avoidance in Indonesia and Malaysia.
Novelty: This study uses manufacturing companies in Indonesia and Malaysia from 2015-2018
Structural, electronic, and thermal studies of Poly(ethylene oxide) based solid-state polymer electrolyte
Authors: Arya Ramesh Kumar , Gupta Abhishek Kumar 
Published: April 2023

Abstract
All-solid-state polymer electrolytes have grown in significance for next-generation energy storage devices because of their high energy endurance, safety, and flexibility. Electrolytes made of poly(ethylene oxide) (PEO) have received a lot of interest because they can dissolve a wide range of ionic salts. We have observed the effects of lithium bis(trifluoromethanesulfonyl)imide salts on the structural, electronic, and thermal properties of solid-state polymer electrolyte systems incorporating PEO using methods based on density functional theory. The highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) i.e., HOMO-LUMO gap of the PEO and polymer electrolyte are found at 5.74 eV and 3.84 eV, respectively. The value of the HOMO-LUMO gap for PEO and solid-state polymer electrolyte shows similarity with the previous studies. The global and local chemical descriptors are calculated using the HOMO-LUMO gap. The electrochemical stability analysis is performed using the HOMO-LUMO method. Thermal functions also have been studied using density functional theory techniques. The theoretical vibrational frequencies of PEO and solid-state polymer electrolyte are investigated and compared with experimental values.
Novel sonic hedgehog gene variant in a patient with hyponatremia, microsomia, and midline defects; phenotype description in association with a variant of unknown significance [c.755_757del p.(Phe252del)] and an approach to salt-wasting in SHH-related adrenal disorders
Authors: Antoniadi Marita , Vitoratou Dimitra Irinna , Marinou Maria , Fafoula Olga , Mylona Fani , Palaiologou Danai , Leandros Lazaros , Kostaridou Stavroula 
Published: April 2023

Abstract

Objective
To contribute a novel sonic hedgehog (SHH) gene variant in association with a novel-meagerly described phenotype and discuss SHH signaling pathway pathology.

Case presentation
We present a 5-year-old boy with excessive hyponatremia and natriuresis, microform holoprosencephaly and microsomia, with morphologically intact hypothalamic–pituitary–adrenal (HPA) axis, and hypoaldosteronism, yet without hyperreninemia, hyperkalemia, dehydration episodes, or glucocorticoid insufficiency. Extensive workup excluded common causes of salt-wasting and revealed a novel variant of unknown significance on the sonic hedgehog (SHH) gene; NM_000193.4:c.755_757del (p.Phe252del), in heterozygosity.

Conclusions
Salt-wasting in children is predominantly caused by central nervous system lesions, renal tubular dysfunction, or adrenal insufficiency. The SHH protein is a signaling molecule, essential in embryogenesis-including HPA axis differentiation. Inactivating SHH variants disrupt the signaling pathway, leading to dysplasia or dysfunction of target organs. What’s new: • We analyze the patient's phenotype in the light of this novel variant • Patient’s isolated aldosterone deficiency possibly implies a selective signaling defect affecting the development of adrenal zona glomerulosa • Unexplained hyporeninemia and hypokalemia in the context of hypoaldosteronism raise questions on SHH signaling pathophysiology.
Künstliche Intelligenz (KI) und die Frage nach dem Menschen
Authors: Meyer-Drawe Käte 
Published: April 2023

Zusammenfassung
Der vorliegende Artikel geht in Interviewform der Frage nach, welche Implikationen die aktuelle Forschung zur Künstlichen Intelligenz für einen modernen Begriff des Menschen hat. Ein besonderes Interesse gilt dabei zwei Konzepten: zum einen dem menschlichen Leib, welcher kein Äquivalent in der Technik hat. Zum zweiten richtet sich die Aufmerksamkeit auf das Lernen: Trotz aller vordergründigen Ähnlichkeit zeigt sich, dass das menschliche Lernen auf eine besondere, leibliche Verankerung in der Welt angewiesen ist, die seine Bedeutung begründet. Die Beschäftigung mit KI hilft dem Menschen, sich über seine Fähigkeiten und Grenzen bewusst zu werden.
Morbidity, mortality, and socioeconomics in Klinefelter syndrome and 47,XYY syndrome: a comparative review
Authors: Ridder Lukas Ochsner , Berglund Agnethe , Stochholm Kirstine , Chang Simon , Gravholt Claus H 
Published: April 2023

Context
Klinefelter syndrome (KS, 47,XXY) and 47,XYY syndrome are genetic conditions characterized by a supernumerary sex chromosome. The conditions share many traits, but considerable phenotypic differences are seen between the two. Focusing on morbidity, mortality, and socioeconomics, this review highlights similarities and differences.

Methods
Relevant literature was identified through PubMed with the following search terms; 'Klinefelter', '47,XXY', '47,XYY', and 'Jacobs syndrome'. Included journal articles were chosen at the authors’ discretion.

Results
KS and 47,XYY are the most common sex chromosome disorders in males, with an expected prevalence of 152 and 98 per 100,000 newborn males, respectively. Non-diagnosis is extensive, as only about 38% of KS and 18% of 47,XYY are diagnosed. Both conditions are associated with an increased mortality risk and increased risk of a variety of diseases and other health-related problems affecting virtually every organ system. Early diagnosis seems to predict a lesser comorbidity burden. Neurocognitive deficits as well as social and behavioral problems are commonly described. Both syndromes are associated with poor socioeconomicfor example, lower income and educational level and higher rates of crime. Infertility is a hallmark of KS, but fertility seems also reduced in 47,XYY.

Conclusion
Being born as a boy with an extra X or Y chromosome is associated with increased mortality and excess morbidity, partially expressed in a sex chromosome-specific pattern.Both syndromes continue to be greatly underdiagnosed, even thoughearly intervention may improve the overall outcome. Earlier diagnosis to initiate timely counseling and treatment should be emphasized.
Human Flourishing, Normativity and Critical Theory
Authors: Bielskis Andrius 
Published: April 2023

Aristotle has traditionally been aligned with conservative social and political philosophy. The conservative reception has been challenged by Alasdair MacIntyre and the Marx-inspired reading of Aristotle. Following MacIntyre’s arguments, this paper sketches an alternative conception of the critical theory beyond the Frankfurt School’s critique of the contemporary culture and the modern society. Critical theory is understood as an attempt to provide both historical analysis and normative critique of the contemporary society and its culture. It argues that normativity should be understood not in Kantian, but in Aristotelian terms. The articulation of Aristotelian conceptions of human flourishing and aretē, rather than that of the bürgerlich conception of Kantian duty, should be at the centre of contemporary theorising. The author claims that Aristotle’s practical philosophy allows us to conceptualise ethics beyond the dominant conceptions of ethical normativity prevalent in the capitalist modernity, while Marx is important because his analysis provides us with theoretical tools for the historically informed critique of the social and economic structures of the modern society.
Pain as a Secondary Quality: A Phenomenological Approach
Authors: Escudero-Morales Alejandro 
Published: April 2023

This work proposes that pain meets the requirements of being characterized as a secondary quality, as it covers, like a color, a determined extension. The argument seeks to establish a literal pain-color analogy through an inquiry into the intensity and location of the pain. From the classic intensity/location relationship reported by patients with acute appendicitis, three degrees of pain are distinguished: mild, moderate, and severe. The objective is only achieved by examining the Body’s extensional determinations (primary quality) insofar as each of these degrees of pain covers three particular measures. Once these three measures have been explored according to the perforation process (tissue damage), the work ends by identifying pain as a transcendent moment.
Reemplazo unicompartimental bilateral de rodilla en un tiempo quirúrgico. Resultados a mediano plazo de 86 prótesis con un seguimiento promedio de 6.2 años
Authors: Gaggiotti Gabriel , Gaggiotti Stefano , Gaggiotti Santino , Ringa Julio César 
Published: April 2023

Objetivo: Evaluar los resultados funcionales, las complicaciones y la supervivencia a mediano plazo de la prótesis unicompartimental bilateral medial o lateral de rodilla en un tiempo quirúrgico.
Materiales y Métodos: Estudio retrospectivo de pacientes con prótesis unicompartimental bilateral medial o lateral de rodilla colocada en un tiempo quirúrgico por gonartrosis entre abril de 2004 y abril de 2020, seguimiento mínimo 1 año. Se evaluaron los resultados clínico-funcionales con el KSS 2011. Se determinaron los tiempos quirúrgico total y de internación, y el requerimiento de transfusiones. Se analizaron las complicaciones a corto y mediano plazo, y las tasas de revisión y de supervivencia de la prótesis.
Resultados: Se evaluaron 86 prótesis unicompartimentales en 43 pacientes (seguimiento promedio 6.1 años). El KSS clínico y funcional aumentó de 46,1 ± 10,2 a 80,9 ± 15,9 y de 22,8 ± 11,9 a 89,8 ± 18,9, respectivamente. La flexión máxima mejoró de 106,3° ± 5,2° a 125,1° ± 4,2° y la contractura en flexión, de 7,5° ± 2,2° a 2,3° ± 1,6°. La cirugía duró 178.6 min y la internación, 39.8 h. Dos pacientes requirieron transfusión. La tasa de complicaciones fue del 6,9%, todas menores. Tres rodillas tuvieron un aflojamiento mecánico aséptico y requirieron revisión a prótesis total de rodilla o nueva prótesis unicompartimental tras 12, 8.6 y 7 años. La supervivencia de la prótesis fue del 96,5%.
Conclusión: La prótesis unicompartimental bilateral medial o lateral en un tiempo quirúrgico para la gonartrosis unicompartimental de rodilla proporciona excelentes resultados clínico-funcionales, con bajas tasas de complicaciones.
A consequence of the notional existence of an effectively calculable yet non-recursive function
Authors: Olszewski Adam 
Published: April 2023

The present paper is devoted to a discussion of the role of Church’s thesis in setting limits to the cognitive possibilities of mathematics. The specific aim is to analyse the formalized theory of arithmetic as a fundamental mathematical structure related to the theory of computation. By introducing notional non-standard computational abilities into this theory, a non-trivial enlargement of the set of theorems is obtained. The paper also indicates the connection between the inclusion of new functions through the development of axioms and the potential modification of inference rules. In addition, the paper provides an explanation of the role of inclusion of a certain interpretation of the meaning of the axioms of the theory in that theory.
LA FORMACIÓN DE LA ENFERMERA EN SALUD OCUPACIONAL
Authors: Toro Restrepo Marta Lucía 
Published: April 2023

El artículo trata sobre la formacíon del recurso profesional de enfermería en salud ocupacional como una necesidad derivada de las condiciones de trabajo de la población. Se plantea la formación y utilización del mismo como una responsabilidad de instituciones empleadoras y formadoras. Por último define cinco retos de la enfermería ocupacional para el siglo XXI
CALIDAD DE ATENCIÓN DE ENFERMERÍA EN LAS SALAS DE TRABAJO DE PARTO
Authors: Escobar Saldarriaga Isabel , Castrillón Agudelo María Consuelo , Pulido de Lalinde Socorro 
Published: April 2023

En el presente estudio se analizó la calidad de la atención que se prestó durante el trabajo de parto a las usuarias en algunas instituciones oficiales de salud del departamento de Antioquia, colombia, en el primer semestre de 1990. Se analizaron tres variables: la función asistencial del profesional de enfermeria, las condiciones de eficiencia de las salas de trabajo de parto y la satisfacción de las gestantes usuarias del servicio. Se investigaron tres poblaciones: las salas de trabajo de parto, los profesionales de enfermería y las gestantes en trabajo de parto; estas poblaciones se estudiaron por medio de entrevistas individuales y colectivas, observación directa y escalas de medición de eficiencia. El estudio muestra que el profesional de enfermería no esta cumpliendo su función asistencial y las instituciones no tienen condiciones de eficiencia mínimas para prestar un servicio con calidad, lo cual afecta la satisfacción de las gestantes. Palabras claves:Calidad de atención en salud, función asistencial, condiciones de aficiencia, satisfacción de gestantes.
PROPUESTA DE JUEGOS PARA NIÑOS HOSPITALIZADOS
Authors: Jiménez Clara Victoria , Del C. Marín Deny , Idárraga Isabel Cristina , Sejín Martha Elena , Vélez Mónica María , Restrepo Yolanda 
Published: April 2023

El presente artículo considera el juego como una labor más de profesional de salud y como un elemento curativo en tanto es una actividad distensionante que le permite al niño enfermo expresar sus fantasías y sus temores además de hacerle más agradable su estadía en el centro hospitalario. Palabras claves:Juego e implementos de juegoSalud infantil
Una propuesta para reformar la salud* Asociación Nacional de Enfermeras de Colombia -ANEC-. Seccional Antioquia
Authors: Duque Cardona Sonia , Castañeda Montoya Mabel , Correa Ulloa Alba Elena , Goméz Tabares Gloria Estela , Palacio Campuzano Marta Lucía , Pérez Peláez Liría , Toro Restrepo Marta Lucia 
Published: April 2023

Se presenta una propuesta de reforma en salud para la Asamblea Nacional Constituyente convocada en Colombia para 1991. Se analizan algunos de los problemas más importantes del sector salud en este momento y se plantea alternativas se solución que deben ser discutidas y consignadas en la nueva Carta Magna del país. Contiene dos ejes principales que orientan toda la propuesta: un concepto diferente de salud y la participación comunitaria en todas las esferas de la reproducción social de los diferentres grupos de población.Al final se representa al articulado correspondiente a los temas tratados.
Centro para la curación del vitiligo.
Authors: Casas Donneys Maria Eugenia 
Published: April 2023

El presente artículo plantea el tratamiento que actualmente ofrece el Centro para la curación del Vitiligo a los pacientes que sufren de esta enfermedad.Las investigaciones adelantadas en la última década, por un grupo de científicos cubanos han permitido poner al alcance de estos pacientes un nuevo medicamento, la Melagenina, que ha demostrado una efectividad del 80% en la curación definitiva de esta enfermedad. El tratamiento farmacológico, el apoyo psicológico y la educación del paciente y su familia son las estrategias que actualmente ofrecce el centro.El Vitiligo se caracteriza como una enfermedad psicosomática, con gran componente familiar, que afecta la producción de melanina, su efecto es una reacción dermatológica de despigmentación que deja espacios "Vacíos de color" , susceptibles a quemaduras solares y cáncer de piel. Se hace referencia a las investigaciones adelantadas en la producción del medicamento, a las técnicas de aplicación y al funcionamienmto del Centro que actualmente opera en Cali, Medellín, Bogotá y Manizales. El centro además de su carácter asistencial desarrolla investigación operativa y actividades educativas para personal de Salud, Pacientes y Comunidad.
Relación entre situaciones emocionales traumáticas y la aparición de cáncer en adultos
Authors: Orrego Sierra Silvia , Pérez Peláez Liria 
Published: April 2023

En el número anterior de esta revista se presentó el marco teórico que sustenta esta investigación en la cual los autores han tratado de identificar la relación existente entre la tensión emocional y el diagnóstico de cáncer.En este artículo se presenta una síntesis del diseño metodológico del trabajo, se hace énfasis en los hallazgos y los análisis referentes a la relación entre eventos emocionales traumáticos, los rasgos de personalidad con tendencia depresiva y su relación con el tipo de cáncer diagnosticado. Para finalizar se presentan las conclusiones y algunas recomendaciones.
Evaluación del Programa de Vigilancia y Control de la Hipertensión Arterial para usuarios del Servicio médico de la Universidad de Antioquia.
Authors: Ochoa de Molina Olga 
Published: April 2023

La primera parte del trabajo informa sobre los objetivos, justificación, filosofía estrategías y funciones del Profesional de Enfermería en el Programa de Vigilancia y Control de la Hipertensión Arterial para Usuarios del Servicio Médico de la Universidad de Antioquia, los cuales están enmarcados dentro del contexto de la Meta SPT/2000.En la segunda parte describe la evaluación del programa realizada a los cinco meses de funcionamiento, encontrando resultados favorables de mejoria en las cifras de la presión sistólica en el 70,2% de los pacientes y de la diastólica en el 63,8%. Además se observa la ausencia de pacientes con Hipertensión severa y el aumento del número de normotensos. Por último se presentan los obstáculos en relación con los pacientes para llevar a cabo el programa.