bluuebunny/crossref_metadata_2025_split huggingface dataset:
A downcore increase in time averaging is the null expectation from the transit of death assemblages through a mixed layer
Authors: Tomašových Adam , Kidwell Susan M. , Dai Ran 
Published: January 2023

AbstractUnderstanding how time averaging changes during burial is essential for using Holocene and Anthropocene cores to analyze ecosystem change, given the many ways in which time averaging affects biodiversity measures. Here, we use transition-rate matrices to explore how the extent of time averaging changes downcore as shells transit through a taphonomically complex mixed layer into permanently buried historical layers: this is a null model, without any temporal changes in rates of sedimentation or bioturbation, to contrast with downcore patterns that might be produced by human activity. Assuming stochastic burial and exhumation movements of shells between increments within the mixed layer and stochastic disintegration within increments, we find that almost all combinations of net sedimentation, mixing, and disintegration produce a downcore increase in time averaging (interquartile range [IQR] of shell ages), this trend is typically associated with a decrease in kurtosis and skewness and by a shift from right-skewed to symmetrical age distributions. A downcore increase in time averaging is thus the null expectation wherever bioturbation generates an internally structured mixed layer (i.e., a surface, well-mixed layer is underlain by an incompletely mixed layer): under these conditions, shells are mixed throughout the entire mixed layer at a slower rate than they are buried below it by sedimentation. This downcore trend created by mixing is further amplified by the downcore decline in disintegration rate. We find that transition-rate matrices accurately reproduce the downcore changes in IQR, skewness, and kurtosis observed in bivalve assemblages from the southern California shelf. The right-skewed shell age-frequency distributions typical of surface death assemblages—the focus of most actualistic research—might be fossilized under exceptional conditions of episodic anoxia or sudden burial. However, such right-skewed assemblages will typically not survive transit through the surface mixed layer into subsurface historical layers: they are geologically transient. The deep-time fossil record will be dominated instead by the more time-averaged assemblages with weakly skewed age distributions that form in the lower parts of the mixed layer.
RETRACTED-Late Permian to early Triassic gabbro in North Lhasa, Tibet: evidence for plume – subduction-zone interaction of the Palaeo-Tethys ocean
Authors: Duan Meng-Long , Xie Chao-Ming , Wang Bin , Song Yu-Hang , Li Wen-qing , Hao Yu-jie 
Published: January 2023

AbstractThe Palaeo-Mesozoic geodynamic evolution of the Tangjia–Sumdo accretionary complex belt, which separates the North and South Lhasa Terrane, remains controversial. Moreover, the lack of geological records restricts the understanding of the evolution of the Sumdo Palaeo-Tethys Ocean from the middle Permian until the middle Triassic. Here we present zircon U–Pb geochronology, whole-rock geochemistry and Sr–Nd–Hf isotopic compositions of the Yeqing gabbro. Zircon U–Pb geochronology yields ages from 254 ± 1 to 249 ± 1 Ma.In situHf isotopic analyses yieldϵHf(t) values of −0.2 to +6.3. These samples have high TiO2(3.69 wt %) and P2O5(0.78 wt %) contents, with typical patterns like ocean island basalt (OIB). Besides, they are classified as high-Nb basalts (HNBs) based on the high content of Nb (45.3–113.5 ppm). Whole-rock Sr–Nd isotopic compositions are similar to OIB, with initial87Sr/86Sr of 0.7047–0.7054,143Nd/144Nd of 0.512526–0.512647 andϵNd(t) of 0.3–2.7. These signatures suggest that the Yeqing gabbro is mainly derived from low-degree melting of the garnet lherzolite mantle. Based on field observations of HNBs intruding into the continental margin and their geochemical characteristics, we infer that the Yeqing gabbro was generated in a subduction environment. Combined with the regional geology of the subduction environment and the evolution of oceanic islands in the Sumdo Palaeo-Tethys Ocean, we propose that the Yeqing gabbro may represent a product of the asthenosphere upwelling through a slab window produced by subduction of seismic ridge in the Sumdo Palaeo-Tethys Ocean, called plume – subduction-zone interaction, during the late Permian to early Triassic.
Rediscovering Carduncellus matritensis: assessing the conservation status of an Iberian endemic
Authors: Luengo Enrique , Martínez-Labarga Juan Manuel , de Pablo Rubén , Susanna Alfonso , Vilatersana Roser 
Published: January 2023

AbstractThe plant Carduncellus matritensis (Cardueae, Compositae) was formerly known from only a single locality: Cerro Negro in Madrid Province, Spain. It is one of the six endemic species of the Spanish flora considered to be extinct. The causes of its presumed extinction were anthropogenic: the growth of the city of Madrid subsumed the locality into the city, such that Cerro Negro is now a railway station. During 2021–2022 we discovered three new populations c. 50 km south of the type locality, with 130–166 mature individuals. Habitat fragmentation and degradation are the most significant threats facing the three populations. We categorize the conservation status of the species as Critically Endangered according to the IUCN Red List criteria. To avoid the loss of this species, we recommend both in situ (creation of micro-reserves) and ex situ (seed storage) conservation measures.
Object Shape and Depth of Word Representations in Preschoolers
Authors: CAPONE SINGLETON Nina , SAKS Jessica 
Published: January 2023

AbstractThis study examined the effect of a shape cue (i.e., co-speech gesture) on word depth. We taught 23 preschoolers (M = 3;5 years, SD = 5.82) novel objects with either shape (SHP) or indicator (IND) gestures. SHP gestures mimicked object form, but IND gestures were not semantically related to the object (e.g., an upward-facing palm, extended toward the object). Each object had a unique IND or SHP gesture. Outcome measures reflected richer semantic and phonological learning in the SHP than in the IND condition. In the SHP condition, preschoolers (a) expressed more semantic knowledge, (b) said more sounds in names, and (c) generalized more names to untaught objects. There were also fewer disruptions to prime picture names in the SHP condition; we discuss the benefit of a co-speech shape gesture to capitalize on well-established statistical word learning patterns.
Trichinella infection in Serbia from 2011 to 2020: a success story in the field of One Health
Authors: Vasilev Sasa , Mitic Ivana , Mirilovic Milorad , Plavsa Dragana , Milakara Emina , Plavsic Budimir , Sofronic-Milosavljevic Ljiljana 
Published: January 2023

Abstract
In Serbia, modern pork production systems with implemented control measures, including the detection of Trichinella larvae in meat (ISO18743), have eliminated farmed pork from pigs slaughtered at abattoirs as a source of trichinellosis. Epidemiological data from 2011 to 2020 indicate that the number of human cases and the number of infected domestic pigs has decreased significantly. Over the years, pork was the most frequent source of human infection. Cases generally occurred in small family outbreaks, and the infection was linked to consumption of raw or undercooked pork from backyard pigs. In most of the outbreaks, T. spiralis was the aetiological agent of infection, but in 2016, a large outbreak was caused by consumption of uninspected wild boar meat containing T. britovi larvae. To achieve safe pork, it is important that consumers of pork from animals raised in backyard smallholdings and of wild game meat are properly educated about the risks associated with consumption of untested meat. Laboratories conducting Trichinella testing should have a functional quality assurance system to ensure competency of analysts and that accurate and repeatable results are achieved. Regular participation in proficiency testing is needed.
Age Differences in Learning-Related Neurophysiological Changes
Authors: Tinga Angelica M. , Menger Nick S. , de Back Tycho T. , Louwerse Max M. 
Published: January 2023

Abstract: Research in young adults has demonstrated that neurophysiological measures are able to provide insight into learning processes. However, to date, it remains unclear whether neurophysiological changes during learning in older adults are comparable to those in younger adults. The current study addressed this issue by exploring age differences in changes over time in a range of neurophysiological outcome measures collected during visuomotor sequence learning. Specifically, measures of electroencephalography (EEG), skin conductance, heart rate, heart rate variability, respiration rate, and eye-related measures, in addition to behavioral performance measures, were collected in younger ( Mage = 27.24 years) and older adults ( Mage = 58.06 years) during learning. Behavioral responses became more accurate over time in both age groups during visuomotor sequence learning. Yet, older adults needed more time in each trial to enhance the precision of their movement. Changes in EEG during learning demonstrated a stronger increase in theta power in older compared to younger adults and a decrease in gamma power in older adults while increasing slightly in younger adults. No such differences between the two age groups were found on other neurophysiological outcome measures, suggesting changes in brain activity during learning to be more sensitive to age differences than changes in peripheral physiology. Additionally, differences in which neurophysiological outcomes were associated with behavioral performance on the learning task were found between younger and older adults. This indicates that the neurophysiological underpinnings of learning may differ between younger and older adults. Therefore, the current findings highlight the importance of taking age into account when aiming to gain insight into behavioral performance through neurophysiology during learning.
Physical and Biogeochemical Properties of Rotten East Antarctic Summer Sea Ice
Authors: Corkill M. , Moreau S. , Janssens J. , Fraser A. D. , Heil P. , Tison J.‐L. , Cougnon E. A. , Genovese C. , Kimura N. , Meiners K. M. , Wongpan P. , Lannuzel D. 
Published: January 2023

AbstractSea ice forms a barrier to the exchange of energy, gases, moisture and particles between the ocean and atmosphere around Antarctica. Ice temperature, salinity and the composition of ice crystals determine whether a particular slab of sea ice is habitable for microorganisms and permeable to exchanges between the ocean and atmosphere, allowing, for example, carbon dioxide (CO2) from the atmosphere to be absorbed or outgassed by the ocean. Spring sea ice can have high concentrations of algae and absorb atmospheric CO2. In the summer of 2016–2017 off East Antarctica, we found decayed and porous granular ice layers in the interior of the ice column, which showed high algal pigment concentrations. The maximum chlorophyll a observed in the interior of the ice column was 67.7 μg/L in a 24% porous granular ice layer between 0.8 and 0.9 m depth in 1.7 m thick ice, compared to an overall mean sea‐ice chlorophyll a (± one standard deviation) of 13.5 ± 21.8 μg/L. We also found extensive surface melting, with instances of snow meltwater apparently percolating through the ice, as well as impermeable superimposed ice layers that had refrozen along with melt ponds on top of the ice. With future warming, the structures we describe here could occur earlier and/or become more persistent, meaning that sea ice would be more often characterized by patchy permeability and interior ice algal accumulations.
High‐Resolution Nighttime Temperature and Rock Abundance Mapping of the Moon Using the Diviner Lunar Radiometer Experiment With a Model for Topographic Removal
Authors: Powell T. M. , Horvath T. , Robles V. Lopez , Williams J.‐P. , Hayne P. O. , Gallinger C. L. , Greenhagen B. T. , McDougall D. S. , Paige D. A. 
Published: January 2023

AbstractThe Diviner Lunar Radiometer Experiment on the Lunar Reconnaissance Orbiter (LRO) has been mapping the surface temperatures of the Moon since 5 July 2009. Diviner has since collected over 500 billion radiometric measurements with excellent spatial and local time coverage. However, the most recently published high‐resolution Diviner global maps only use data collected from 2009 to 2016. In this work, we compile ∼13 years of Diviner data to produce improved global maps of nighttime brightness temperature, bolometric temperature, regolith temperature, and rock abundance (RA). Errors in Diviner's pointing have been corrected and past effective field of view modeling has been optimized to improve data georeferencing without spatial interpolation. We estimate an effective resolution of ∼330 m longitudinally and ∼700 m latitudinally at the equator, which corresponds to an improvement of ∼3.5× longitudinally and ∼1.3× latitudinally. In addition, we develop a thermal model that accounts for indirect scattering and emission from surrounding topography. The resulting temperature anomaly maps better highlight variations in temperature caused by thermophysical properties by removing most topographic effects. These improvements allow for the identification of smaller and fainter thermal features than was previously possible. The improved effective resolution of Diviner maps allows for excellent spatial correlation with other high‐resolution data sets. To demonstrate this, we compare Diviner RA to a manual survey of boulders in the Apollo 17 landing site region. We show that Diviner RA correlates well with the areal fraction of rocks larger than ∼1–2 m in diameter visible in LRO Camera imagery.
Estimates for Tethys' Moment of Inertia, Heat Flux Distribution, and Interior Structure From Its Long‐Wavelength Topography
Authors: Gyalay Szilárd , Nimmo Francis 
Published: January 2023

AbstractWe examine if Saturn's moon Tethys may be an ocean world by assuming that spatial variations in tidal heating are responsible for thickness or temperature variations in an isostatic ice shell, which manifests as surface topography. Because patterns of tidal heating depend on average ice shell thickness and whether the shell overlies a rigid or liquid layer, we can use Tethys' long‐wavelength topography to infer its interior structure. We test a wide range of assumed parameters to hone in on the characteristics of Tethys that produce self‐consistent and physically plausible interior models. To verify our technique, we apply it to Enceladus and recover the signature of a sub‐surface global ocean with an appropriately thick ice shell and moment of inertia. Our best‐fit Tethys models require Pratt isostasy and obliquity tides, with a normalized moment of inertia 0.340–0.345 and an average surface heat flux 1–2 mW m−2. The best‐fit basal heat flux distribution indicates that Tethys does not have an ocean. The total power inferred (4–8 GW) to produce Tethys' shape from tidal heating indicates either a highly dissipative interior or an obliquity higher than previously estimated. The topography may also be a relic of a warmer past when the obliquity was higher.
Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis
Authors: Wu Ne N. , Wang Lifeng , Wang Lu , Xu Xihui , Lopaschuk Gary D. , Zhang Yingmei , Ren Jun 
Published: January 2023

AbstractMitochondrial DNA (mtDNA) released through protein oligomers, such as voltage-dependent anion channel 1 (VDAC1), triggers innate immune activation and thus contributes to liver fibrosis. Here, we investigated the role of Parkin, an important regulator of mitochondria, and its regulation of VDAC1-mediated mtDNA release in liver fibrosis. The circulating mitochondrial DNA (mtDNA) and protein levels of liver Parkin and VDAC1 were upregulated in patients with liver fibrosis. A 4-week CCl4 challenge induced release of mtDNA, activation of STING signaling, a decline in autophagy, and apoptosis in mouse livers, and the knockout of Parkin aggravated these effects. In addition, Parkin reduced mtDNA release and prevented VDAC1 oligomerization in a manner dependent on its E3 activity in hepatocytes. We found that site-specific ubiquitination of VDAC1 at lysine 53 by Parkin interrupted VDAC1 oligomerization and prevented mtDNA release into the cytoplasm under stress. The ubiquitination-defective VDAC1 K53R mutant predominantly formed oligomers that resisted suppression by Parkin. Hepatocytes expressing VDAC1 K53R exhibited mtDNA release and thus activated the STING signaling pathway in hepatic stellate cells, and this effect could not be abolished by Parkin. We propose that the ubiquitination of VDAC1 at a specific site by Parkin confers protection against liver fibrosis by interrupting VDAC1 oligomerization and mtDNA release.
Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
Authors: Loe Adrian Kwan Ho , Zhu Lexin , Kim Tae-Hee 
Published: January 2023

AbstractGastric cancer (GC) is one of the most common and deadly cancers in the world. It is a multifactorial disease highly influenced by environmental factors, which include radiation, smoking, diet, and infectious pathogens. Accumulating evidence suggests that epigenetic regulators are frequently altered in GC, playing critical roles in gastric tumorigenesis. Epigenetic regulation involves DNA methylation, histone modification, and noncoding RNAs. While it is known that environmental factors cause widespread alterations in DNA methylation, promoting carcinogenesis, the chromatin- and noncoding RNA-mediated mechanisms of gastric tumorigenesis are still poorly understood. In this review, we focus on discussing recent discoveries addressing the roles of histone modifiers and noncoding RNAs and the mechanisms of their interactions in gastric tumorigenesis. A better understanding of epigenetic regulation would likely facilitate the development of novel therapeutic approaches targeting specific epigenetic regulators in GC.
Hypertension: sex-related differences in drug treatment, prevalence and blood pressure control in primary care
Authors: Bager Johan-Emil , Manhem Karin , Andersson Tobias , Hjerpe Per , Bengtsson-Boström Kristina , Ljungman Charlotta , Mourtzinis Georgios 
Published: January 2023

AbstractAntihypertensive treatment is equally beneficial for reducing cardiovascular risk in both men and women. Despite this, the drug treatment, prevalence and control of hypertension differ between men and women. Men and women respond differently, particularly with respect to the risk of adverse events, to many antihypertensive drugs. Certain antihypertensive drugs may also be especially beneficial in the setting of certain comorbidities – of both cardiovascular and extracardiac nature – which also differ between men and women. Furthermore, hypertension in pregnancy can pose a considerable therapeutic challenge for women and their physicians in primary care. In addition, data from population-based studies and from real-world data are inconsistent regarding whether men or women attain hypertension-related goals to a higher degree. In population-based studies, women with hypertension have higher rates of treatment and controlled blood pressure than men, whereas real-world, primary-care data instead show better blood pressure control in men. Men and women are also treated with different antihypertensive drugs: women use more thiazide diuretics and men use more angiotensin-enzyme inhibitors and calcium-channel blockers. This narrative review explores these sex-related differences with guidance from current literature. It also features original data from a large, Swedish primary-care register, which showed that blood pressure control was better in women than men until they reached their late sixties, after which the situation was reversed. This age-related decrease in blood pressure control in women was not, however, accompanied by a proportional increase in use of antihypertensive drugs and female sex was a significant predictor of less intensive antihypertensive treatment.
Vaccine evaluation and genotype characterization in children infected with rotavirus in Qatar
Authors: Mathew Shilu , Al Khatib Hebah A. , Al Ibrahim Malak , Al Ansari Khalid , Smatti Maria K. , Nasrallah Gheyath K. , Ibrahim Emad , Al Thani Asmaa A. , Zaraket Hassan , Yassine Hadi M. 
Published: January 2023

Abstract
Background
We characterized and identified the genetic and antigenic variations of circulating rotavirus strains in comparison to used rotavirus vaccines.

Methods
Rotavirus-positive samples (n = 231) were collected and analyzed. The VP7 and VP4 genes were sequenced and analyzed against the rotavirus vaccine strains. Antigenic variations were illustrated on the three-dimensional models of surface proteins.

Results
In all, 59.7% of the hospitalized children were vaccinated, of which only 57.2% received two doses. There were no significant differences between the vaccinated and non-vaccinated groups in terms of clinical outcome. The G3 was the dominant genotype (40%) regardless of vaccination status. Several amino acid changes were identified in the VP7 and VP4 antigenic epitopes compared to the licensed vaccines. The highest variability was seen in the G3 (6 substitutions) and P[4] (11 substitutions) genotypes in comparison to RotaTeq®. In comparison to Rotarix®, G1 strains possessed three amino acid changes in 7-1a and 7-2 epitopes while P[8] strains possessed five amino acid changes in 8-1 and 8-3 epitopes.

Conclusions
The current use of Rotarix® vaccine might not be effective in preventing the infection due to the higher numbers of G3-associated cases. The wide range of mutations in the antigenic epitopes compared to vaccine strains may compromise the vaccine’s effectiveness.

Impact

The reduced rotavirus vaccine effectiveness necessitate regular evaluation of the vaccine content to ensure optimal protection.

We characterized and identified the genetic and antigenic variations of circulating rotavirus strains in comparison to the Rotarix vaccine strain that is used in Qatar.

The study highlight the importance for regular monitoring of emerging rotavirus variants and their impact on vaccine effectiveness in young children.
Localized coevolution between microbial predator and prey alters community-wide gene expression and ecosystem function
Authors: Hogle Shane L , Ruusulehto Liisa , Cairns Johannes , Hultman Jenni , Hiltunen Teppo 
Published: January 2023

Abstract
Closely interacting microbial species pairs (e.g., predator and prey) can become coadapted via reciprocal natural selection. A fundamental challenge in evolutionary ecology is to untangle how coevolution in small species groups affects and is affected by biotic interactions in diverse communities. We conducted an experiment with a synthetic 30-species bacterial community where we experimentally manipulated the coevolutionary history of a ciliate predator and one bacterial prey species from the community. Altering the coevolutionary history of the focal prey species had little effect on community structure or carrying capacity in the presence or absence of the coevolved predator. However, community metabolic potential (represented by per-cell ATP concentration) was significantly higher in the presence of both the coevolved focal predator and prey. This ecosystem-level response was mirrored by community-wide transcriptional shifts that resulted in the differential regulation of nutrient acquisition and surface colonization pathways across multiple bacterial species. Our findings show that the disruption of localized coevolution between species pairs can reverberate through community-wide transcriptional networks even while community composition remains largely unchanged. We propose that these altered expression patterns may signal forthcoming evolutionary and ecological change.