bluuebunny/crossref_metadata_2025_split huggingface dataset:
UHFB‐Overlay auf Fuß‐ und Radwegbrücke Karl‐Heine‐Bogen in Leipzig
Authors: Sagmeister Bernhard , Reichel Michael , Huß Michael , Mayer Michael 
Published: June 2023

AbstractBei einer Fuß‐ und Radwegbrücke über den Karl‐Heine‐Kanal in Leipzig wurden im Rahmen einer Bauwerksprüfung Undichtigkeiten in der Abdichtungsschicht aus reaktionsharzgebundenem Dünnschichtbelag (RHD) festgestellt. Darüber hinaus waren kleinere Betonschäden in Form von Abplatzungen vorhanden. Um eine langfristige Dauerhaftigkeit zu gewährleisten, wurden die Betonschäden beseitigt und die alte Abdichtung durch eine ultrahochfeste Faserbetonschicht, kurz UHFB‐Deckschicht, von 30 mm Stärke ersetzt. Die neue Deckschicht hat nur eine Abdichtungsfunktion, die damit einhergehende Tragfähigkeitssteigerung wurde bei den Überlegungen nicht berücksichtigt. Wegen des möglichen Pannenrisikos für Fahrradreifen wurden anstelle von starren Stahlfasern biegsame PVA‐Kunststofffasern verwendet. Auf ca. 160 m2 Fläche wurden innerhalb eines Tages insgesamt 6,5 m3 faserverstärkter UHFB händisch verbaut.
Precision fermentation with mass spectrometry‐based spent media analysis
Authors: Dodia Hardik , Sunder Avinash Vellore , Borkar Yogen , Wangikar Pramod P. 
Published: June 2023

AbstractOptimization and monitoring of bioprocesses requires the measurement of several process parameters and quality attributes. Mass spectrometry (MS)‐based techniques such as those coupled to gas chromatography (GCMS) and liquid Chromatography (LCMS) enable the simultaneous measurement of hundreds of metabolites with high sensitivity. When applied to spent media, such metabolome analysis can help determine the sequence of substrate uptake and metabolite secretion, consequently facilitating better design of initial media and feeding strategy. Furthermore, the analysis of metabolite diversity and abundance from spent media will aid the determination of metabolic phases of the culture and the identification of metabolites as surrogate markers for product titer and quality. This review covers the recent advances in metabolomics analysis applied to the development and monitoring of bioprocesses. In this regard, we recommend a stepwise workflow and guidelines that a bioprocesses engineer can adopt to develop and optimize a fermentation process using spent media analysis. Finally, we show examples of how the use of MS can revolutionize the design and monitoring of bioprocesses.
Using MetaboAnalyst to introduce undergraduates to lipidomic analysis and lipid remodeling in barley roots
Authors: Reyna Mercedes , Peppino Margutti Micaela , Vilchez Ana Carolina , Villasuso Ana Laura 
Published: June 2023

AbstractLipidomics is a discipline that focuses on the identification and quantification of lipids. Although a part of the larger omics field, lipidomics requires specific approaches for the analysis and biological interpretation of datasets. This article presents a series of activities for introducing undergraduate microbiology students to lipidomic analysis through tools from the web‐based platform MetaboAnalyst. The students perform a complete lipidomic workflow, which includes experiment design, data processing, data normalization, and statistical analysis of molecular phospholipid species obtained from barley roots exposed to Fusarium macroconidia. The input data are provided by the teacher, but students also learn about the methods through which they were originally obtained (untargeted liquid chromatography coupled with mass spectrometry). The ultimate aim is for students to understand the biological significance of phosphatidylcholine acyl editing. The chosen methodology allows users who are not proficient in statistics to make a comprehensive analysis of quantitative lipidomic datasets. We strongly believe that virtual activities based on the analysis of such datasets should be incorporated more often into undergraduate courses, in order to improve students' data‐handling skills for omics sciences.
Cyclohexenone Derivative and Drimane Sesquiterpenes from the Seagrass‐Derived Fungus Aspergillus insuetus
Authors: Hu Zhibo , Chen Junjie , Liu Qianqian , Wu Qilin , Chen Shenhua , Wang Junjian , Li Jing , Liu Lan , Gao Zhizeng 
Published: June 2023

AbstractOne new cyclohexenone derivative (1), and two undescribed drimane sesquiterpenes (2 and 3), together with another seven known drimane sesquiterpenes were isolated from a seagrass‐derived fungus Aspergillus insuetus SYSU6925. Structures of these metabolites were elucidated by comprehensive spectroscopic analysis, including NMR analysis, mass spectrometry, and ECD calculations. Compounds 1–3, 5 and 7 displayed weak to moderate antifungal activities towards four phytopathogenic fungi, with Minimum inhibition concentration (MIC) values range from 50 to 200 μg/mL. Compound 1, a rare cyclohexenone derivative with n‐propyl group exhibited more potent inhibitory activities (MIC, 50 μg/mL) against F. oxysporum than positive control (Triadimefon). Compounds 2 and 3 also exhibit potent anti‐inflammatory activities by inhibiting the production of nitric oxide (NO) in RAW264.7 cells with IC50 values of 21.5±1.1 and 32.6±1.16 μM, respectively.
Cemtirestat, an aldose reductase inhibitor and antioxidant compound, induces ocular defense against oxidative and inflammatory stress in rat models for glycotoxicity
Authors: Reihanifar Tala , Şahin Muzaffer , Stefek Milan , Ceylan Aslı F. , Karasu Çimen ,   Antioxidants in Diabetes‐Induced Complications (ADIC) Study Group
Published: June 2023

AbstractFructose, endogenously produced as a consequence of activation of the polyol pathway under hyperglycemic conditions, contribute to formation of advanced glycoxidation end products (AGEs) and carbonyl stress. Oxidative stress is increased in diabetes (DM) due to AGEs formation and the utilization of NADPH by aldo‐keto reductase, AKR1B1(AR), the first enzyme in polyol pathway. Since inhibition of AR is an attractive approach for the management of diabetic eye diseases, we aimed to compare the effects of a novel AR inhibitor (ARI)/antioxidant (AO) compound cemtirestat on eye tissues with the effects of ARI drug epalrestat and AO agent stobadine in rat model for glycotoxicity. One group of rats was fed high fructose (10% drinking water; 14 weeks), while type‐2 DM was induced in the other group of rats with fructose plus streptozotocin (40 mg/kg‐bw/day). Diabetic (D) and nondiabetic fructose‐fed rats (F) were either untreated or treated with two different doses of cemtirestat (2.5 and 7.5 mg/kg‐bw/day), epalrestat (25 and 50 mg/kg‐bw/day), or stobadine (25 and 50 mg/kg‐bw/day) for 14 weeks. Cemtirestat, epalrestat, and stobadine elaviate the increase in TNF‐α, IL‐1β, NF‐ƙB, and caspase‐3 in retina, lens, cornea, and sclera of F and D rats. Both glycotoxicity models resulted in a decrease in GSH to GSSG ratio and a change in glutathione S‐transferase activity in eye tissues, but these alterations were improved especially with cemtirestat and stobadine. Lens D‐sorbitol of D rats increased more than that of F rats, this increase was only attenuated by cemtirestat and epalrestat. Epalrestat was more effective than cemtirestat and stobadine in inhibiting the increase of vascular endothelial growth factor (VEGF) in the retina of F and D rats. Cemtirestat and stobadine but not epalrestat decreased high level of Nε‐(carboxymethyl)lysine in the lens and retina of F and D rats. Cemtirestat is a potential therapeutic in protecting the rat eye against glycotoxicity insults.
Solid‐state and submerged fermentation effects on functional properties of pea protein‐enriched flour
Authors: Batbayar Barkhas , Kryachko Yuriy , Nickerson Michael T. , Korber Darren R. , Tanaka Takuji 
Published: June 2023

AbstractBackground and ObjectivesModification of plant proteins is often required to make them suitable substitutes for animal proteins in food applications. The effects of fermentation on the quality and functional properties of pea protein‐enriched flour (PPEF) were evaluated in this study. PPEF was fermented by Aspergillus oryzae, Rhizopus oryzae, Rhizopus oligosporus, Lactobacillus plantarum, and Bacillus subtilis strains using solid‐state and submerged fermentation (SSF and SmF, respectively).FindingsProtein contents significantly increased following fermentation for all samples, while lipid contents significantly decreased in SSF and increased in SmF samples. Surface properties were modified: enhanced zeta potential and decreased surface hydrophobicity were observed. At pH 7, emulsification activities and stabilities increased in A. oryzae and R. oligosporus samples, and emulsion stability increased for all fermented samples. Water and oil holding capacities increased after fermentation. SmF‐PPEF showed generally more significant changes in these properties.ConclusionsFermentation improved the functional properties of PPEF to varying degrees, depending on the mode of fermentation, pH conditions, and fermenting strains.Significance and NoveltyThis research demonstrates that fermentation can be efficient in modifying various functional properties of legume proteins, thus, helping increase their values.
An Optimized System for the Study of Rieske Oxygenase‐catalyzed Hydroxylation Reactions In vitro
Authors: Runda Michael Ernst , Kremser Bastian , Özgen Fatma Feyza , Schmidt Sandy 
Published: June 2023

AbstractRieske non‐heme iron oxygenases (ROs) are primarily known for their ability to catalyze the stereoselective formation of vicinal cis‐diols in a single step, endowing valuable products for pharmaceutical and chemical applications. In addition, ROs can catalyze several other oxidation reactions with high regio‐ and stereoselectivity and typically broad substrate scope. Owing to their dependence on multicomponent electron transfer, the majority of synthetic applications of ROs relies on recombinant whole‐cell catalysts. In this context, important properties of the multicomponent system that determine the catalytic efficiency, including electron transfer via redox partner proteins, stability and uncoupling, have been investigated to a lesser extent in recent years. Here, we show for one of the most prominent ROs, the cumene dioxygenase from Pseudomonas fluorescens IP01 (CDO) that by developing and optimizing an efficient in vitro system, high catalytic activities can be achieved. In addition, we highlight that an efficient and continuous supplementation of electrons to the oxygenase is required to sustain their catalytic activity, while uncoupling can be a major limitation in CDO efficiency and stability.
Metal‐Free Direct C3−H Alkylation and Arylation of Quinoxalin‐2(1H)‐Ones with Inert Alkyl and Aryl Chlorides
Authors: Tripathy Alisha Rani , Mishra Ashutosh , Singh Vesaj , Yatham Veera Reddy 
Published: June 2023

AbstractIn the present manuscript, we reported the first visible‐light‐enabled direct C3−H alkylation/arylation of quinoxalin‐2(1H)‐ones with unactivated alkyl/aryl chlorides under metal‐free conditions. A wide range of unactivated alkyl and aryl chlorides containing different functionalities are coupled with a variety of quinoxalin‐2(1H)‐one derivatives under mild reaction conditions to afford the C3‐alkyl/aryl substituted quinoxalin‐2(1H)‐ones in moderate to good yields.
Dissymmetric Triaryltriazines: Small Mass Columnar Glasses
Authors: Nunes da Silva Fabrícia , Marchi Luciano Hugo , Stadtlober Carlos H. , Farias Giliandro , Durola Fabien , Eccher Juliana , Bechtold Ivan H. , Bock Harald , Gallardo Hugo , Vieira André A. 
Published: June 2023

AbstractColumnar liquid crystals with very small molecular masses that form anisotropic glasses well above room temperature are obtained by mixed dissymmetric substitution of sym‐triazine with ester‐bearing phenyl and phenanthryl or tetrahelicenyl moieties. The combination of low molecular symmetry with configurational flexibility and short polar ester moieties stabilizes the mesophase over large temperature ranges and induces pronounced calorimetric glass transitions within the anisotropic fluid despite the smallness of the molecules. In contrast to more symmetrical homologs, no ester tails longer than ethyl are necessary to induce the liquid crystalline state, allowing for the near‐absence of any insulating and weight‐increasing alkyl periphery. Films drop‐cast from solution show in all cases emission spectra that do not show significant change of fluorescence emission upon annealing, indicating that the columnar hexagonal mesoscopic order is obtained directly upon deposition from solution and is resistant to crystallization upon annealing.
Degradation of Penicillinic Antibiotics and β‐Lactamase Enzymatic Catalysis in a Biomimetic Zn‐Based Metal–Organic Framework
Authors: Escamilla Paula , Bartella Lucia , Sanz‐Navarro Sergio , Percoco Rita Maria , Di Donna Leonardo , Prejanò Mario , Marino Tiziana , Ferrando‐Soria Jesús , Armentano Donatella , Leyva‐Pérez Antonio , Pardo Emilio 
Published: June 2023

Abstractβ‐Lactam antibiotics are one of the most commonly prescribed drugs to treat bacterial infections. However, their use has been somehow limited given the emergence of bacteria with resistance mechanisms, such as β‐lactamases, which inactivate them by degrading their four‐membered β‐lactam rings. So, a total knowledge of the mechanisms governing the catalytic activity of β‐lactamases is required. Here, we report a novel Zn‐based metal–organic framework (MOF, 1), possessing functional channels capable to accommodate and interact with antibiotics, which catalyze the selective hydrolysis of the penicillinic antibiotics amoxicillin and ceftriaxone. In particular, MOF 1 degrades, very efficiently, the four‐membered β‐lactam ring of amoxicillin, acting as a β‐lactamase mimic, and expands the very limited number of MOFs capable to mimic catalytic enzymatic processes. Combined single‐crystal X‐ray diffraction (SCXRD) studies and density functional (DFT) calculations offer unique snapshots on the host‐guest interactions established between amoxicillin and the functional channels of 1. This allows to propose a degradation mechanism based on the activation of a water molecule, promoted by a Zn‐bridging hydroxyl group, concertedly to the nucleophilic attack to the carbonyl moiety and the cleaving of C−N bond of the lactam ring.
Tuning the Photophysical Properties of Aza‐BODIPYs in the Near‐Infrared Region by Introducing Electron‐Donating Thiophene Substituents
Authors: Baron Thibaut , Maffeis Valentin , Bucher Christophe , Le Guennic Boris , Banyasz Akos , Jacquemin Denis , Berginc Gérard , Maury Olivier , Andraud Chantal 
Published: June 2023

AbstractThis study presents the synthesis, the spectroscopic and electrochemical properties of new bis‐ and tetra‐substituted azaboron‐dipyrromethene (aza‐BODIPY) dyes substituted by different electron donating groups connected to the aza‐BODIPY core through a thiophene unit. In line with theoretical calculations, experimental measurements point out the positive impact of the thiophene group that behave as a secondary donor group leading to an enhancement of the intramolecular charge transfer process in comparison to previously reported aza‐BODIPY dyes. This heterocycle has also been found to tune the oxidative potential and to stabilize the electro‐generated species.
Iron‐Catalyzed Alkoxylation, Dehydrogenative‐Polymerization and Tandem Hydrosilylative‐Alkoxylation
Authors: Sen Anirban , Kumar Rohit , Tewari Tanuja , Gonnade Rajesh G. , Chikkali Samir H. 
Published: June 2023

AbstractAlkoxylation, hydrosilylative‐alkoxylation, and dehydrogenative‐polymerization are some of the most widely used transformations in synthetic chemistry. However, these transformations are traditionally catalyzed by precious, and rare late‐transition metals. Presented here is a molecularly defined iron complex that catalyzes alkoxylation, tandem hydrosilylative‐alkoxylation, and dehydrogenative polymerization of silanes under mild conditions. The iron complex [Fe(CO)4(H)(SiPh3)] 1 catalyzes a direct Si−O coupling reaction between an array of silanes and alcohols to produce desired alkoxysilanes in excellent yield, with H2 as the only byproduct. The iron catalyst tolerates various functional groups and provides access to 20 alkoxysilanes, including essential molecules such as β‐citronellol and cholesterol. Further, complex 1 catalyzes the polymerization of renewable diol and silane monomer to produce a renewable and degradable poly(isosorbide−silyl ether). Remarkably, complex 1 catalyzes a tandem hydrosilylative‐alkoxylation of alkynes under mild conditions to yield unsaturated silyl ethers. The synthetic utility has been demonstrated by gram‐scale alkoxylation and hydrosilylative‐alkoxylation reactions.
Mit Weitsicht zur autonomen Anlage
Authors: Annison Julian 
Published: June 2023

AbstractDie Digitalisierung in der Prozessindustrie hatte schon immer wirtschaftliche Treiber wie ein verbessertes Energie‐ und Emissionsmanagements sowie die Erhöhung der Sicherheit und der betrieblichen Zuverlässigkeit. Doch heute sollen Unternehmen geschäftlich optimiert werden und gleichzeitig die strengen Ziele der ökologischen Nachhaltigkeit und Dekarbonisierung erreichen und zwar nachhaltig bis 2050. Eine weitsichtige digitale Transformation wird dabei unterstützen und den Anlagenbetrieb mehr und mehr automatisieren und autonomisieren.

inhaltliche Anforderungen der EU/spez. Industriestandards/zu erwartende deutsche Normen,
unser Konzept für CSRD‐konforme Digitale Nachhaltigkeitsberichte über eine Bottom up‐Methode über die Produkte der Unternehmen im Mittelpunkt,
produktspezifische Datenanalysen, KPI' s, Messbarkeit, Bewertungen (PCF, PEF, LCA),
Prozesssteuerung und Effizienzverbesserungen über digitale Lösungen,
Zukunftsentwicklungen (z.B. auch Einschätzungen zu KI, wie ChatGPT o.ä.)
Empfehlungen
Kosmetikprodukte aus Fischabfällen
Authors: Sutthoff René 
Published: June 2023

AbstractDie Idee für das Startup Ray Cosmetics aus äthiopien kam CEO und Gründerin Rewla Ephrem und ihren Mitstreitern Yared Assefa und Abrehame Dessie am malerischen Tana‐See in Bahirdar. Unterstützt vom ISC3 produziert das Start‐up biobasiertes Kollagen aus Fischhaut.
Die Geometrie optimal nutzen
Authors: Anstöter Stefan 
Published: June 2023

AbstractDas Thema Energieeffizienz gewinnt gerade bei Pumpentechnologien wieder an Bedeutung. Aufgrund ihrer Effizienz rücken deshalb auch pneumatische, druckluftbetriebene Doppelmembranpumpen immer weiter in den Fokus. Der Pumpenhersteller Timmer arbeitet daran, das Potenzial dieser Art von Pumpen weiter auszuschöpfen.
Digitale Zukunft für große Kompressoren
Authors: Steck Ralf 
Published: June 2023

AbstractDie Kompressoren des Schweizer Unternehmens Burckhardt Compression werden in der Energie‐ und Chemieindustrie eingesetzt, wo eine extrem hohe Verfügbarkeit gefordert wird. Der Kompressorenhersteller arbeitet gemeinsam mit PTC daran, die Softwarelösungen für Remote Service, IoT und Augmented Reality in der Praxis effizient und gewinnbringend einzusetzen. Die Zukunft der Instandhaltung sehen die Partner im industriellen Metaverse.
Effizienter Antrieb von hochdrehenden Motoren
Authors: Blankenburg Torsten 
Published: June 2023

AbstractIn den neuen Turbokompressoren von Boge ist die Drei‐Level‐Technologie des Frequenzumrichters SD2M von Sieb & Meyer eingebaut. Sie reduziert Rotor‐Verluste und vermeidet somit eine zu hohe Motor‐Erwärmung, die bei Hochgeschwindigkeitsanwendungen problematisch ist. Der Frequenzumrichter verfügt zudem über eine MODBUS‐Schnittstelle und eine optimierte Wasserkühlung.
Electrically Driven Crosslinked Liquid Crystal Polymers†
Authors: Wang Meng , Jiang Chuan‐Fei , Yang Hong 
Published: June 2023

Comprehensive SummaryCrosslinked liquid crystal polymers (CLCPs) are smart materials that combine the anisotropy of liquid crystals (LCs) with the elasticity of rubber. When subjected to external stimuli, they exhibit exceptional two‐way shape memory behavior. Among the various stimuli, electrical energy has the advantages of cleanliness, stability, and high controllability; hence, it is widely used for controlling CLCP‐based soft actuators, thus presenting potential for application in diverse, complex scenarios. By combining electrically driven mode and sensor equipment, precise control of CLCPs can be achieved, and the electrically driven CLCPs can accomplish more intricate and sophisticated tasks. This study presents a comprehensive review of electrically driven CLCPs with various driving mechanisms, including the electroclinic effect of ferroelectric CLCPs, the reorganization of LC molecules, the Maxwell effect of dielectric CLCPs, and the Joule heating effect of electrothermally responsive CLCP systems. In addition, a detailed analysis of the applications of electrically driven CLCPs in various research fields is presented. Finally, the current challenges in the field of electrically driven CLCP technology are summarized, along with predictions for future prospects.
Piezoelectric Zinc Oxides with High Polar Facets Ratios for Mechanically Controlled RAFT Polymerization†
Authors: Ding Chengqiang , Ren Ziye , Wang Jian , Zhang Longfei , Yan Yuhan , Wu Danming , Wang Zhao , Zhang Zhengbiao 
Published: June 2023

Comprehensive SummaryMechanoredox chemistry that uses highly polarized piezoelectric materials as mechanoredox catalysts to promote redox reactions has emerged recently. It provides an alternative approach alongside the existing polymerization methods. Despite recent accomplishments, determining the quantitative relationship between the structure of ZnO and its catalytic performance for polymerization is still challenging. Herein, we prepared various ZnO crystals with different polar facets ratios to achieve efficient mechanically induced reversible addition‐fragmentation chain transfer polymerization (mechano‐RAFT). ZnO prepared from Zn(NO3)2 showed a high polar facet ratio of 1.66 and offered the highest catalytic activity among all ZnO samples. A near‐quantitative initiator efficiency of 99.5% and narrow molecular weight distribution were achieved for the polymerization of n‐butyl acrylate. Furthermore, the high chain‐end fidelity and chain extension capability were also evidenced by MALDI‐TOF MS and GPC analysis. This work highlighted the significant contribution of polar facets in ZnO to its catalytic activity and will guide the design of mechanoredox catalysis with superior catalytic performance in the future.
Objective model selection with parallel genetic algorithms using an eradication strategy
Authors: Plante Jean‐François , Larocque Maxime , Adès Michel 
Published: June 2023

AbstractIn supervised learning, feature selection methods identify the most relevant predictors to include in a model. For linear models, the inclusion or exclusion of each variable may be represented as a vector of bits playing the role of the genetic material that defines the model. Genetic algorithms reproduce the strategies of natural selection on a population of models to identify the best. We derive the distribution of the importance scores for parallel genetic algorithms under the null hypothesis that none of the features has predictive power. They, hence, provide an objective threshold for feature selection that does not require the visual inspection of a bubble plot. We also introduce the eradication strategy, akin to forward stepwise selection, where the genes of useful variables are sequentially forced into the models. The method is illustrated on real data, and simulation studies are run to describe its performance.