bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Bilayer Elasto-Hydrogel Adhesive Film for Facilitating Wet-Occlusive Therapy for Atopic Dermatitis
Authors: Pillai Joshua P. , Pillai Jonathan D. 
Published: February 2023

AbstractAtopic dermatitis (AD) is a common chronic multifactorial skin disease that causes skin inflammation owing to defects in the skin barrier, immune dysregulation, or infectious agents. The most common treatment of AD utilizes wet-occlusion therapies to create a protective skin barrier by providing moisture to the epidermis. However, these treatments are suboptimal in managing disease symptoms owing to their limited ability to retain or restore skin hydration and inefficient drug delivery. Currently, there are no effective approaches for treating AD that are specifically designed to improve drug delivery efficacy and skin hydration. This study aims to introduce a new approach of localized drug delivery and facilitate more efficient dermal hydration using hydrogels and elastomers. Herein, we report a simple yet effective bilayer elasto-hydrogel adhesive film (BEHAF) dressing made from an interpenetrating alginate and polyacrylamide (alginate/AAm) hydrogel layer backed by a thin film of polydimethylsiloxane elastomer. In an in vitro hydration study, it was found that the BEHAF dressing enabled efficient retention and delivery of hydration to a model epidermis for more than 48 h and showed potential for drug delivery of both hydrophobic and hydrophilic drugs. Furthermore, mechanical testing results indicate that the BEHAF mimics the elastic behavior of human skin and shows good adhesion sensitivity, thereby suggesting biomechanical compatibility and suitability for long-term usage. Overall, the BEHAF dressing may provide a viable vehicle for dermal hydration and drug delivery, thereby improving the efficacy of wet-occlusive therapy for treating AD.
Development of a Passive Reactor Shutdown Device to Prevent Core Disruptive Accidents in Fast Reactors: A Preliminary Study
Authors: Morita Koji , Liu Wei , Arima Tatsumi , Arita Yuji , Sato Isamu , Matsuura Haruaki , Sekio Yoshihiro , Sagara Hiroshi , Kawashima Masatoshi 
Published: February 2023

AbstractFollowing the Fukushima Nuclear Power Plant accident in 2011, it has become increasingly important for reactor safety designs to consider measures that can prevent the occurrence of severe accidents. This report proposes a novel subassembly-type passive reactor shutdown device that expands the diversity and robustness of core disruptive accident (CDA) prevention strategies for sodium-cooled fast reactors. The developed device contains pins with a fuel material that is in the solid state during normal operation but melts into a liquid when the temperature exceeds a certain value (i.e., during a potential accident). When an unprotected loss of flow (ULOF) or unprotected transient overpower (UTOP) accident occurs, the device can passively provide significant negative reactivity by rapidly transferring liquefied device fuel into the lower plenum region of the pins via gravitation alone. The reactors containing some of the proposed devices in place of original fuel subassemblies become subcritical before the driver fuels are damaged, even if ULOF or UTOP transient events occur. The present study evaluates candidate materials for device fuels (e.g., metallic alloy, chloride), optimal device pin structures for liquefied fuel relocation, and nuclear and thermal-hydraulic characteristics of the device-loaded core under accident conditions to demonstrate the engineering applicability of the proposed device. This report discusses preliminary results regarding the nuclear requirements for inducing negative reactivity to achieve reactor shutdown under the expected device conditions during an accident.
Study on the Performance of a Cycloidal Rotor in Hover at Different Reynolds Numbers
Authors: Zimmer Florian , Gagnon Louis 
Published: February 2023

AbstractThis paper studied the influence of the Reynolds number on lift, power, and efficiency of a three-bladed cycloidal rotor in hover. In a parameter study, Reynolds numbers from 10,000 to 600,000 were investigated. The fluid mechanics were solved using incompressible 2D unsteady Reynolds-averaged Navier–Stokes (URANS) computational fluid dynamics (CFD). The CFD model was first carefully validated using experimental data for a pitching airfoil undergoing dynamic stall. The model was then verified to reproduce the shapes of both the force and power curves and the wake flow of a landmark cyclorotor experimental study. Two different flow regimes were identified: for the first regime Re ranged from 10,000 to 100,000 and two dynamic flow separations occurred, the first at maximum pitch angle and bottommost position of the blade and the second shortly afterwards. The second flow regime had Re from 200,000 to 600,000 and avoided the first separation due to the increased Reynolds number. Both separations were visible in the flow as well as in the azimuthal lift distribution. Regardless of the flow regime, rotation averaged lift and power followed the predictions of momentum theory, except for Re of 500,000. At this Re, a significant drop in power was observed and corresponds to findings of a 20-year old experimental study which were at the time classified as possibly wrong. This particular behavior at Re of 500,000 is explained by a change in shape of the downwash, which avoids flow separation as the blade starts to travel upwards.
The trilinear Higgs self-couplings at $$\mathcal {O}(\alpha _t^2)$$ in the CP-violating NMSSM
Authors: Borschensky Christoph , Dao Thi Nhung , Gabelmann Martin , Mühlleitner Margarete , Rzehak Heidi 
Published: February 2023

AbstractIn supersymmetric theories the Higgs boson masses are derived quantities where higher-order corrections have to be included in order to match the measured Higgs mass value at the precision of current experiments. Closely related through the Higgs potential are the Higgs self-interactions. In addition, the measurement of the trilinear Higgs self-coupling provides the first step towards the reconstruction of the Higgs potential and the experimental verification of the Higgs mechanism sui generis. In this paper, we advance our prediction of the trilinear Higgs self-couplings in the CP-violating Next-to-Minimal Supersymmetric extension of the SM (NMSSM). We provide the $$\mathcal{O}(\alpha _t^2)$$

O
(

α
t
2

)

corrections in the gaugeless limit at vanishing external momenta. The higher-order corrections turn out to be larger than the corresponding mass corrections but show the expected perturbative convergence. The inclusion of the loop-corrected effective trilinear Higgs self-coupling in gluon fusion into Higgs pairs and the estimate of the theoretical uncertainty due to missing higher-order corrections indicate that the missing electroweak higher-order corrections may be significant.
The equilibrium and dynamical cumulants of QCD chiral order parameter with parametric Landau free energy
Authors: Jiang Lijia , Stöcker Horst , Zheng Jun-Hui 
Published: February 2023

AbstractBy linearly parameterizing the QCD Landau free energy near the critical point in the baryon chemical potential and temperature plane, we study the fluctuations of the QCD chiral order parameter field (the $$\sigma $$
σ
field) in the equilibrium case and dynamical phase transition, respectively. By setting the system size to the typical size of the QGP fireball ($$\approx 10^3$$

≈

10
3

fm$$^3$$

3

), we show that in the equilibrium case, the discontinuity of the order parameter in the first order phase transition region is replaced by smooth crossover, and the corresponding fluctuations are broadened. Meanwhile, the quartic cumulant $$\kappa _4$$

κ
4

of the $$\sigma $$
σ
field is generally negative near the phase transition line. We further derive the dynamical evolution of the QCD Landau free energy in the Fokker–Plank framework, based on which we deduce the dynamical cumulants of the $$\sigma $$
σ
field. Assuming the temperature decreases as a known function of time, we numerically evaluate the dynamical cumulants and confirm that the cumulants present clear memory effects. Moreover, the memory effects on the first order phase transition side is stronger than that on the crossover side, and the dynamical cumulants at the hypothetical freeze-out line present rich non-monotonic structures.
Anisotropic stars made of exotic matter within the complexity factor formalism
Authors: Rincón Ángel , Panotopoulos Grigoris , Lopes Ilídio 
Published: February 2023

AbstractWithin Einstein’s General Relativity we study exotic stars made of dark energy assuming an extended Chaplygin gas equation-of-state. Taking into account the presence of anisotropies, we employ the formalism based on the complexity factor to solve the structure equations numerically, obtaining thus interior solutions describing hydrostatic equilibrium. Making use of well-established criteria we demonstrate that the solutions are well behaved and realistic. A comparison with another, more conventional approach, is made as well.
Non-Gaussian entanglement of magnetically coupled modes: A dynamical analysis
Authors: Hab-arrih Radouan , Jellal Ahmed , Merdaci Abdeldjalil 
Published: February 2023

The quantum entanglement of two connected harmonic oscillators via angular momentum yielding a magnetic coupling [Formula: see text] is discussed in this study. The corresponding Hamiltonian is diagonalized by using three canonical transformations, and then the stationary wave function is obtained. The Schmidt decomposition is used to explicitly determine the modes [Formula: see text], with [Formula: see text], [Formula: see text] and [Formula: see text] being two quantum numbers associated with the two oscillators. We summarize our findings by looking at the effects of anisotropy [Formula: see text], [Formula: see text], asymmetry [Formula: see text], and dynamics on entanglement. (i) With increasing [Formula: see text], the entanglement grows exceedingly large. (ii) The sensitivity to [Formula: see text] is determined by [Formula: see text] and [Formula: see text]. The physical parameters and quantum numbers play a great role in the periodic resuscitation of entanglement.
An Amendable Multi-Function Control Method using Federated Learning for Smart Sensors in Agricultural Production Improvements
Authors: Abu-Khadrah Ahmed , Ali Ali Mohd , Jarrah Muath 
Published: February 2023

Communications and Computer Engineering Department, Faculty of Engineering, Al-Ahliyya Amman University, Amman 19328, Jordan
School of Information Technology, Skyline University, Sharjah, 1797, UAE
Smart Sensors are used for monitoring, sensing, and actuating controls in small and large-scale agricultural plots. From soil features to crop health and climatic observations, the smart sensors integrate with sophisticated technologies such as the Internet of Things or cloud for decentralized processing and global actuation. Considering this integration, an Amendable Multi-Function Sensor Control (AMFSC) is introduced in this proposal. This proposed method focuses on sensor operations that aid agricultural production improvements. The agriculture hindering features from the soil, temperature, and crop infections are sensed and response is actuated based on controlled operations. The control operations are performed according to the sensor control validation and modified control acute sensor, which helps to maximize productivity. The sensor control and operations are determined using federated learning from the accumulated data in the previous sensing intervals. This learning validates the current sensor data with the optimal data stored for different crops and environmental factors in the past. Depending on the computed, sensed, and optimal (adaptable) data, the sensor operation for actuation is modified. This modification is recommended for crop and agriculture development to maximize agricultural productivity. In particular, the sensing and actuation operations of the smart sensors for different intervals are modified to maximize production and adaptability. The efficiency of the system was evaluated using different parameters and the system maximizes the analysis rate (12.52%), control rate (7%), adaptability (9.65%) and minimizes the analysis time (7.12%), and actuation lag (8.97%)
Unpacking the mediating role of resilience in the relationship between ideal-actual self-discrepancy, stressful life events, depression and anxiety: Results from 1,144 young people in an epidemiological study in Hong Kong
Authors: Nam Suen Yi , Cheuk Ying Crystal Ling , Charlton Cheung , Lai Ming Christy Hui , Ming Yin Stephanie Wong , Tak Hing Michael Wong , Kit Wa Sherry Chan , Ho Ming Edwin Lee , Yu Hai Eric Chen 
Published: February 2023

Background: Self-discrepancy is associated with poorer mental health, yet its mechanism is understudied. A recent study found that resilience plays a moderating role in the relationship between self-discrepancy and depressive symptoms in adults. The current study investigated whether there were any similar relationships among young people aged 15 to 24 years. Methods: As part of the ongoing Hong Kong Epidemiological Study of Mental Health (HK-YES) project, the current study analysed data from 1,144 participants who provided complete data on ideal-actual selfdiscrepancy, psychiatric conditions, resilience level and recent stressful life events (SLEs). Results: Ideal-actual self-discrepancies were associated with increased depressive and anxiety symptoms, as well as odds of 12-month major depressive episodes (MDEs) and generalised anxiety disorder (GAD). All these associations became nonsignificant after adjusting for resilience. Separate models found resilience mediating rather than moderating the relationship. According to four-way decomposition, the pure indirect effect explained most of the total effects of self-discrepancy on mental health conditions. The mediation effects on symptom severity were recently revealed to be more prominent among individuals with substantial exposure to SLE. Conclusions: Resilience functions mainly as a mediator in the relationship between self-discrepancy and mental health conditions, and its effect is weakened by the exposure of SLEs. Important implications are discussed regarding the use of resilience-focused interventions and the consideration of recent adversity.
Opening Pandora's Box: The Extreme Right and the Resurgence of Racism in Brazil
Authors: Bernardino-Costa Joaze 
Published: February 2023

The emergence of Bolsonarism as a face of the extreme right in Brazil has come out of the articulation of several groups mobilized on social networks around a handful of key ideas including moral conservatism, economic liberalism, patriotism, public security, and a common enemy. Research on social networks and articles in the press shows that Bolsonarism has opened a Pandora's box, releasing behavior that combines racist antiracialism and racist racialism and that aims to dismantle the recent achievements of black and indigenous groups. A emergência do Bolsonarismo como manifestação da extrema direita no Brasil deve sua origem à articulação de vários grupos que se mobilizaram nas redes sociais em torno de um conjunto de idéias chaves que inclui um inimigo comum, um conservadorismo moral, um liberalismo econômico, o patriotismo e a segurança pública. Estudos sobre as redes sociais e artigos nos jornais mostram que o Bolsonarismo tem abrido uma caixa de Pandora, fomentando um comportamento que combina o antiracialismo racista com um racialismo racista que almeja desmontar os sucessos recentes conseguidos por grupos negros e indígenas.
Pursuing Diversity: The Context, Practices, and Diversity Outcomes of Intentionally Diverse Charter Schools
Authors: Seifert Sophia , Porter Lorna , Cordes Sarah A. , Wohlstetter Priscilla 
Published: February 2023

Background: In the United States, students’ experiences are shaped by racioethnic, socioeconomic, and linguistic segregation. School choice, and especially charter schools, generally exacerbate existing levels of school segregation. Counter to this trend, hundreds of intentionally diverse charter schools (IDCS), with a mission to promote school diversity, have opened across the country. Purpose: This study aims to clarify how IDCS operationalize their mission to serve diverse populations. To do so, we examine contextual factors that influence diversification efforts, the strategies that IDCS use to pursue diverse enrollments, and whether sample IDCS are more diverse than comparison schools. Research Design: This study uses a convergent mixed-methods design, in which qualitative and quantitative data were independently collected and analyzed, then merged for final analysis. The qualitative phase included thematic analyses of 101 interviews and 40 focus groups with IDCS staff and leaders to identify key contextual factors and practices that shape diversification efforts. For quantitative analyses, we used student and school-level administrative data from sample and comparison schools in New York, Colorado, and California. We explored researcher-created diversity outcomes for sample and comparison schools, including a racioethnic diversity index representing the probability that any two students chosen at random will be of a different race/ethnicity, and locally created diversity goals of having 40%–50% of enrolled students qualify for free/reduced price lunch (FRL) and no racial majority group among enrolled students. Conclusions/Recommendations: We found that local context, including race-neutral state policies and local housing patterns, created barriers to recruiting and enrolling diverse students. To overcome these barriers, IDCS staff developed data-driven recruitment and enrollment practices that were differentiated by the target group. Practices focused on increasing awareness of the school, building trust, and investing parents in the schools’ diversity mission. Enrollment data show that sample IDCS are more diverse than a set of comparison schools, with mixed results when analyzing diversity outcomes with locally defined goals. We conclude that, despite contextual barriers, choice schools have considerable agency in fostering school diversity.
Acute severe pulmonary hypertension during weaning from cardiopulmonary bypass for aortic valve replacement surgery: A case report
Authors: Xiong Jiyue , Liu Ting , Zheng Jianqiao , Du Lei , Lin Jing 
Published: February 2023

Pulmonary arterial pressure (PAH) usually increases after cardiopulmonary bypass (CPB), but this normally does not affect weaning off CPB. Here we report a case of severe PAH in a patient with normal left atrial pressure. Prolonging CPB by 45 min did not lead to lower PAH. Given that lung injury can stimulate secretion of vasoconstrictors that trigger PAH, we decided to gradually increase blood flow into the lungs in an effort to restore the balance between pulmonary vasoconstrictors and vasodilators. Pulmonary artery pressure gradually decreased, allowing the patient to be weaned off CPB, after which she recovered uneventfully. Our experience suggests an approach for managing acute, severe PAH after CPB without the need for mechanical circulatory support.
A phase 1b study to investigate the potential interactions between ASP8062 and buprenorphine/naloxone in patients with opioid use disorder
Authors: Ito Mototsugu , Walzer Mark , Beth Blauwet Mary , Spence Anna , Heo Nakyo , Kelsh Debra , Blahunka Paul , Erdman Jay , Nour Alsharif Mohamad , Marek Gerard J 
Published: February 2023

Background: There is an unmet need for therapeutics with greater efficacy and tolerability for the treatment of opioid use disorder (OUD). ASP8062 is a novel compound with positive allosteric modulator activity on the γ-aminobutyric acid type B receptor under development for use with standard-of-care treatment for patients with OUD. Aims: To investigate the safety, tolerability, interaction potential, and pharmacokinetics (PK) of ASP8062 in combination with buprenorphine/naloxone (B/N; Suboxone®). Methods: In this phase 1, randomized, double-masked, placebo-controlled study, patients with OUD began B/N (titrated to 16/4 mg/day) treatment upon enrollment (induction, Days 1–4; maintenance, Days 5–18; downward titration, Days 19–26; and discharge, Day 27). On Day 12, patients received a single dose of ASP8062 60 mg or placebo with B/N and underwent safety and PK assessments. Primary endpoints included frequency and severity of treatment-emergent adverse events (TEAEs), clinical laboratory tests, respiratory depression, and suicidal ideation. Secondary endpoints investigated the impact of ASP8062 on B/N PK. Results: Eighteen patients were randomized and completed the study (ASP8062, n = 12; placebo, n = 6). With this sample size typical for phase 1 drug–drug interaction studies, ASP8062 was well tolerated; most TEAEs were mild in severity, and none led to treatment withdrawal. ASP8062 did not enhance substance use-related TEAEs, respiratory depression, or suicidal ideation and did not have a clinically significant impact on the PK of B/N. Conclusions: In this phase 1 study, ASP8062 was safe, well tolerated, and did not enhance respiratory suppression induced by buprenorphine. Trial registration: Clinicaltrials.gov identifier: NCT04447287.
CircKRT14 upregulates E2F3 by interacting with miR-1256 to act as an oncogenic factor in esophageal cancer
Authors: Guan Xingzhuo , Lan Tingzhu , Wang Yuanshi , Cui Yan , Duan Jinyu , Xu Hongjun 
Published: February 2023

Background A growing number of studies have focused on the regulatory role of circular RNAs (circRNAs) in a variety of cancers. The purpose of this study was to investigate the effect of circRNA Keratin 14 (circKRT14) on the progression of esophageal cancer (EC). Methods The levels of circKRT14, miR-1256 and E2F transcription factor 3 (E2F3) were analyzed by real-time quantitative polymerase chain reaction (qRT-PCR) and western blot. The circular structure of circKRT14 was confirmed by RNase R digestion assay. Cell apoptosis, migration and invasion were detected by flow cytometry and transwell assay. The protein levels of related factors were determined by western blot. The relationship between miR-1256 and circKRT14 or E2F3 was verified by dual-luciferase reporter assay. The in vivo function of circKRT14 was studied by xenograft tumor assay. Results CircKRT14 was significantly increased in EC tissues and cells. CircKRT14 silencing inhibited EC cell proliferation, migration, and invasion, but promoted EC cell apoptosis in vitro. CircKRT1 acted as a sponge for miR-1256 in EC, and in-miR-1256 abolished the inhibitory effect of circKRT14 suppression on EC cell progression. E2F3 was a target of miR-1256 and functioned as an oncogene in EC cells. MiR-1256 curbed EC progression by downregulating E2F3. CircKRT14 could affect E2F3 expression by targeting miR-1256. CircKRT14 regulated EC progression in vivo through miR-1256/E2F3 axis. Conclusions These results uncovered that circKRT14 up-regulated the expression of E2F3 and promoted the malignant development of EC through sponging miR-1256.