bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Human Induced Pluripotent Stem Cells for Tissue Engineered Cardiomyocyte Modelling
Authors: Katili Puspita A. , Karima Amira P. , Azwani Winda , Antarianto Radiana D. , Djer Mulyadi M. 
Published: July 2023

Abstract
Purpose
Cardiac
tissue engineering opens up opportunities for regenerative therapy in heart diseases. Current technologies improve engineered cardiac tissue characteristics by combining human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with non-cardiomyocytes, selective biomaterials, and additional growth factors. Animal models are still required to determine cardiac patches’ overall in vivo effect before initiating human trials. Here, we review the current in vivo studies of cardiac patches using hiPSC-CMs.

Methods
We performed a literature search for studies on cardiac patch in vivo application and compared outcomes based on cell engraftment, functional changes, and safety profiles.

Results
Present studies confirm the beneficial results of combining hiPSC-CMs with other cardiac cell lineages and biomaterials. They improved the functional capacity of the heart, showed a reduction in infarct size, and initiated an adaptive inflammatory process through neovascularisation.

Conclusion
The cardiac patch is currently the most effective delivery system, proving safety and improvements in animal models, which are suggested to be the role of the paracrine mechanism. Further studies should focus on honing in vitro patch characteristics to achieve ideal results.

Lay Summary
Cardiac tissue engineering answers the demand for regenerative therapy in heart diseases. Combining human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with biomaterials and growth factors in cardiac patches improves the heart’s structural and functional characteristics. This delivery system is safe and efficient for delivering many cells and minimising cellular loss in vivo. Rat and porcine models of ischemic and non-ischemic heart diseases demonstrated the benefits of this therapy, which include cell engraftment, reduced infarct size, and increased left ventricular (LV) systolic function, with no reported critical adverse events. These reports sufficiently provide evidence of feasible improvements to proceed towards further trials.
Gendering Counter-Terrorism: Kunya and the Silencing of Male Victims of CRSV in Northeastern Nigeria
Authors: Njoku Emeka Thaddues , Dery Isaac 
Published: July 2023

AbstractAs the silence of male CRSV victims continues to be debated, some argue that gender norms and a lack of agency contribute to the silence of victims, even as others assert that victims exercise agency by speaking selectively about their experiences. In northern Nigeria, the concept of kunya—a model for appropriate behaviour rooted in the importance of secrecy and discretion—plays a role in the silencing of victims. We examine how kunya contributes to the invisibility of victims and influences their silence, as well as how victims use silence to gain social tolerability and/or protect themselves from re-victimization. We argue that an attentiveness to such community-specific cultural precepts and norms can further our understanding of the silence (and silencing) of victims and survivors.
Statistical constraints on climate model parameters using a scalable cloud-based inference framework
Authors: Carzon James , Abreu Bruno , Regayre Leighton , Carslaw Kenneth , Deaconu Lucia , Stier Philip , Gordon Hamish , Kuusela Mikael 
Published: July 2023

Abstract
Atmospheric aerosols influence the Earth’s climate, primarily by affecting cloud formation and scattering visible radiation. However, aerosol-related physical processes in climate simulations are highly uncertain. Constraining these processes could help improve model-based climate predictions. We propose a scalable statistical framework for constraining the parameters of expensive climate models by comparing model outputs with observations. Using the C3.AI Suite, a cloud computing platform, we use a perturbed parameter ensemble of the UKESM1 climate model to efficiently train a surrogate model. A method for estimating a data-driven model discrepancy term is described. The strict bounds method is applied to quantify parametric uncertainty in a principled way. We demonstrate the scalability of this framework with 2 weeks’ worth of simulated aerosol optical depth data over the South Atlantic and Central African region, written from the model every 3 hr and matched in time to twice-daily MODIS satellite observations. When constraining the model using real satellite observations, we establish constraints on combinations of two model parameters using much higher time-resolution outputs from the climate model than previous studies. This result suggests that within the limits imposed by an imperfect climate model, potentially very powerful constraints may be achieved when our framework is scaled to the analysis of more observations and for longer time periods.
Unpartitionable: C.H. Alexandrowicz, Sovereign Divisibility, and the Longue Durée of the Polish-Lithuanian Commonwealth
Authors: Loefflad Eric 
Published: July 2023

AbstractIn recent years, scholars of international legal history have demonstrated much newfound interest in C.H. Alexandrowicz, a Polish jurist renowned for his anti-Eurocentric revisionist account of Asian and African agency within the meta-narrative of international law. Building on efforts to link his Polish origins with his studies of the Afro-Asian world, especially on matters of imperialism and state personality, my purpose in this Article is to explore these connections through a materially grounded historical sociology of international legal thought. Centering the issue of whether sovereignty is divisible, I situate the historic Polish-Lithuanian Commonwealth—extinguished by a series of Partitions in 1772, 1793, and 1795—as a unique divided sovereignty-based polity that provided a basis for Alexandrowicz’s study of the juridical status of non-European sovereigns. This analogy united his overarching critique of nineteenth-century international legal positivism as an unjustifiable denial of both Polish and Afro-Asian sovereignty. In deciphering the materiality of Alexandrowicz’s imagination against this presumption, I build a narrative of the Polish-Lithuanian Commonwealth and the evolution of its distinct approach to sovereign divisibility. Through analysis of the interplay between internal and external factors, I account for the Commonwealth’s medieval origins, its development in opposition to the consolidating indivisible sovereignty of its absolutist neighbors, its attempts to maintain independence in the face of Partition, and the continued assertions of its variegated legacies following its destruction. This, I argue, provides a novel means of assessing Alexandrowicz’s theory, and the materiality of international law more generally.
Constraining the evolution of shear zones in the Himalayan mid crust in Central–Western Nepal: implications for the tectonic evolution of the Himalayan metamorphic core
Authors: Carosi Rodolfo , Montomoli Chiara , Iaccarino Salvatore , Cottle John M. , Massonne Hans-Joachim , Nania Laura , Simonetti Matteo 
Published: July 2023

AbstractStructural analysis, petrochronology and metamorphic petrology enable identification and bracketing of the timing of a newly mapped high-temperature ductile shear zone (Jagat Shear Zone (JSZ)) in the Himalayan metamorphic core in Central-Western Nepal. In situ U-Th-Pb monazite petrochronology constrains the timing of top-to-the-S/SW shearing between 28–27 Ma and 17 Ma. Burial and prograde metamorphisms in footwall rocks were linked to thrust-sense movement along the JSZ, while the hanging wall rocks were retrogressed and exhumed. The identification and age of the JSZ (as part of a regional system of shear zones: the High Himalayan Discontinuity (HHD)) coupled with the localization and timing of activity of the Main Central Thrust (MCT) (i) fills a gap in tracing the HHD along orogenic strike, (ii) supports the identification of the position and timing of the long-debated MCT and (iii) helps to place the boundaries of the Himalayan metamorphic core and its internal architecture. Thus, our study is a significant step towards a precise identification of the burial, assembly and exhumation mechanisms of the Himalayan metamorphic core.
The Scottish Enlightenment and the Remaking of Modern History
Authors: Pye Tom 
Published: July 2023

AbstractThis article offers a new interpretation of the history-writing produced in Enlightenment Scotland. It argues that after the Jacobite rebellion of 1745 was blamed on Scotland's ‘feudal’ institutions, Scottish jurists and historians began to interrogate what it meant to become 'modern'. Instead of accepting the Whig claim that England provided the ideal model for social and political development, they subsumed English history into a broader debate about whether and how modern Europe had emerged from its feudal past. By reconstructing this debate, the article shows how Scots rewrote European history in ways that subverted the English whig tradition while rejecting universal or ‘cosmopolitan’ explanations of social progress. In doing so, the article reopens the question of how the Scottish Enlightenment shaped British imperial culture across the eighteenth and early nineteenth centuries.
‘It’s always difficult for women’: an analysis of the life stories of sub-Saharan migrant women
Authors: Gutiérrez-García Ana Isabel , Jiménez-Ruiz Ismael , Siles-González José , Perpiñá-Galvañ Juana , Solano-Ruíz Carmen 
Published: July 2023

AbstractThe aim of this study was to understand the perspectives of female residents of Spain from West Africa in terms of the factors that condition their lives. Pierre Bourdieu’s theory and the model of intersectionality formed the framework we used to qualitatively analyse the life stories of these women, which was complemented with life lines. The results showed us that traditional practices such as female genital mutilation and forced marriage are part of the social habitus of this group and they relate to each other through the several types of violence that occurs throughout their lives. In addition, in reference to the African community, these women were no longer African, while in terms of the Spanish community, they did not seem Spanish. At a health, political, and social level, this knowledge can help us to understand this group and to create personalised targeted interventions for them.
Coronavirus disease 2019 pandemic telephone two-week-wait referrals in head and neck cancer – how safe were they?
Authors: Lau Kin Lun , Wilson Margarita , Oozeer Nashreen , Cocks Helen 
Published: July 2023

AbstractObjectiveDuring the coronavirus disease 2019 pandemic, ENT-UK recommended a move from face-to-face clinics to telephone appointments. This study reviewed the safety of telephone clinics for urgent two-week-wait cancer referrals.MethodsPatients consulted in telephone clinics between April and November 2020 were identified from an electronic database. Study patients included those diagnosed with malignant disease at six months. The Head and Neck Cancer Risk Calculator version 2 score, outcome of the initial clinic and final diagnoses were reviewed.ResultsA total of 1062 patients were triaged in clinic; 9.2 per cent (n = 98) were diagnosed with cancer at 6 months. Of these 98 patients, 69 received an urgent face-to-face appointment, 26 underwent urgent scans and 3 had a delayed telephone review. Twenty patients (20.4 per cent) diagnosed with cancer had a low-risk Head and Neck Cancer Risk Calculator score.ConclusionThe late diagnosis rate of 0.28 per cent suggests a small proportion of cancer could have been missed. Telephone clinics, whilst a pragmatic means to maintain patient flow during the pandemic, could result in late diagnoses.
The messy practice of decolonising a concept: Everyday humanitarianism in Tanzania
Authors: Sulley Consolata Raphael , Richey Lisa Ann 
Published: July 2023

AbstractThis article1 explores the messy practice of decolonising a concept through collaborative work between scholars researching together the meaning of everyday humanitarianism in Tanzania. Humanitarianism is typically understood as the state-centric, formal, Northern-driven helping of distant others in crisis. Using the concept of everyday humanitarianism, our article challenges these assumptions in three ways. First, it explores the everyday humanitarian actions of ordinary citizens in times of crisis. Second, it explores these responses in a Southern context. Third, it focuses explicitly on the givers and not only the receivers of humanitarian help. Our work grounds decolonisation in the actual practices of research aimed at theory building as an iterative back-and-forth exchange with particular attention to power, rather than as a transplant of Northern theory on the South, or its opposite. Our first argument is that the objective of collaborative research to capture the local politics of giving and then use these practices to interrogate the theoretical concept of everyday humanitarianism can be decolonising. Second, we argue that the practices of the academic labour that produces knowledge or inductive theory can also be decolonising. Understanding both the challenges and the possibilities of decolonising ‘humanitarianism’ will provide an opportunity to document and thus legitimate the complexity that is inherent in decolonising a discipline.
Pan-African gender governance: The politics of aspiration at the African Union
Authors: Tornius Karmen 
Published: July 2023

AbstractThe African Union (AU) has developed an elaborate gender governance architecture, including gender machineries and women’s desks, policy frameworks, path-breaking women’s rights laws, and ongoing campaigns on women’s rights–related issues. At the same time, the member states’ engagement with this architecture is at best lukewarm, with a lack of domestication, compliance, and accountability. This paradox is addressed in this article by developing the theoretical thinking around aspirational politics (Martha Finnemore and Michelle Jurkovich, ‘The politics of aspiration’, International Studies Quarterly, 64:4 [2020], pp. 759–69) and political brokers (Stacie E. Goddard, ‘Brokering change: Networks and entrepreneurs in international politics’, International Theory, 1:2 [2009], pp. 249–81), showing the social and relational origins of pan-African gender governance. In doing so, the article examines how ‘aspirational politics’ can be operationalized to examine the sociocultural and political production of shared future imaginaries. The paper focuses on AU femocrats as the key actors for AU’s aspirational gender agenda and argues for their importance as political brokers between AU member states, donors, UN agencies, and civil society organisations. By mobilizing actors and facilitating common ground and agreement, their institutionalized broker position allowed for various political entrepreneurs to emerge and thrive. At the same time, their pursuits are met with ‘aspirational fatigue’ or outright contestation by the member states. The case of the AU demonstrates how aspirational politics is not a ‘phase’ leading to norms governance but part and parcel of normative negotiation and engagement.
The effect of tree-on-tree interactions and abiotic conditions on woody communities in Brazilian savannas
Authors: Chagas Davi Borges , Rapini Alessandro , Villa Pedro Manuel , Collevatti Rosane Garcia 
Published: July 2023

AbstractFire plays a crucial role in shaping plant communities in South American savannas. However, the impact of biotic interactions on tree communities still needs to be better explored. In this study, we evaluated the influence of tree-on-tree interactions and abiotic conditions on the structure and diversity of woody communities in savannas of Central Brazil. We used plots of 10 × 10 m in three preservation areas of savanna to assess the abundance and composition of juveniles and adults in woody communities associated with two Apocynaceae tree species:Hancornia speciosa, postulated to show negative interactions with the associated tree community, andHimatanthus obovatus, postulated to show positive interactions. Our results revealed that while abiotic factors, represented by the altitude, are more critical in shaping the community of juvenile trees, tree-on-tree interactions have a stronger influence on adult tree populations, driving community dynamics during plant recruitment. Specifically,Hancornia speciosareduces the abundance of adults, whereasHimatanthus obovatusenhances their relative abundance; both shape the composition of tree communities. Consequently, tree-on-tree interactions create distinct mosaics at various stages of regeneration, contributing to savanna dynamics and conservation.
Contrasting Drought Propagation Into the Terrestrial Water Cycle Between Dry and Wet Regions
Authors: Li Wantong , Reichstein Markus , O Sungmin , May Carla , Destouni Georgia , Migliavacca Mirco , Kraft Basil , Weber Ulrich , Orth Rene 
Published: July 2023

AbstractDrought's intensity and duration have increased in many regions over the last decades. However, the propagation of drought‐induced water deficits through the terrestrial water cycle is not fully understood at a global scale. Here we study responses of monthly evaporation (ET) and runoff to soil moisture droughts occurring between 2001 and 2015 using independent gridded datasets based on machine learning‐assisted upscaling of satellite and in‐situ observations. We find that runoff and ET show generally contrasting drought responses across climate regimes. In wet regions, runoff is strongly reduced while ET is decoupled from soil moisture decreases and enhanced by sunny and warm weather typically accompanying soil moisture droughts. In drier regions, ET is reduced during droughts due to vegetation water stress, while runoff is largely unchanged as precipitation deficits are typically low in these regions and ET decreases are buffering runoff reductions. While these water flux drought responses are controlled by the large‐scale climate regimes, they are additionally modulated by local vegetation characteristics. Land surface models capture the observed water cycle responses to drought in the case of runoff, but not for ET where the ET deficit (surplus) is overestimated (underestimated), related to a misrepresentation of the general soil moisture‐evaporation interplay. In summary, our study illustrates how the joint analysis of machine learning‐enhanced Earth observations can advance the understanding of global eco‐hydrological processes, as well as the validation of land surface models.
Modeling the Morphological Responses of the Yellow River Delta to the Water‐Sediment Regulation Scheme: The Role of Impulsive River Floods and Density‐Driven Flows
Authors: Wu Guoxiang , Wang Kemeng , Liang Bingchen , Wu Xiao , Wang Houjie , Li Huajun , Shi Benwei 
Published: July 2023

AbstractMorphological evolution of river deltas depends to a large extent on river discharges, which are usually highly unsteady due to natural hydrological cycles and anthropogenic regulations. However, it is unclear that how and to what extent the discharge fluctuations influence the delta morphology. In this study, we focus on the morphological response of the Yellow River Delta to the Water‐Sediment Regulation Schemes, which generate impulsive floods and deliver high sediment load within a short time. Tracking the fate of fluvial sediment released by 10 historical events reveals that 51.3%, 19.7%, and 17.8% of fluvial sediment are deposited in the delta front, the subaerial delta and the prodelta, respectively. Hypopycnal and hyperpycnal flows occur alternately during different phases of the regulation schemes, and the latter contribute to 32% of the deposition volume with 10% of the duration. To explore the effects of river discharge schematizations on delta evolution, numerical experiments are conducted to compare models forced by unsteady and constant discharges, with the latter being a common practice in delta morphology modeling. We show that the constant‐discharge simplification fails to capture the highly‐depositional hyperpycnal flows, leading to dramatic underestimation of river mouth depositions. In addition, we demonstrate that including the 3D flow‐sediment interactions are critical in reproducing the correct plume structures, bed surface sediment compositions and deposition patterns. Our study highlights the importance of proper river discharge schematizations and full consideration of flow‐sediment interactions in modeling deltas affected by episodic river floods and high suspended sediment concentrations.
Optimal Postprocessing Strategies With LSTM for Global Streamflow Prediction in Ungauged Basins
Authors: Tang Senlin , Sun Fubao , Liu Wenbin , Wang Hong , Feng Yao , Li Ziwei 
Published: July 2023

AbstractStreamflow prediction in ungauged basins (PUB) is challenging, and Long Short‐Term Memory (LSTM) is widely used to for such predictions, owing to its excellent migration performance. Traditional LSTM forced by meteorological data and catchment attribute data barely highlight the optimum data integration strategy for LSTM and its migration from data‐rich basins to ungauged ones. In this study, we experimented with 1,897 global catchments and found that LSTM‐corrected Global Hydrological Models (GHMs) outperformed uncorrected GHMs, improving the median Nash‐Sutcliff efficiency (NSE) from 0.03 to 0.66. Notably, there was a large gap between traditional LSTM modeling in ungauged basins and autoregressive modeling in data‐rich basins, and GHM‐forced LSTM were an effective way to close this gap in ungauged basins. The spatial heterogeneity of the performance of GHM‐forced LSTM was mainly influenced by three metrics (dryness, the leaf area index and latitude), which described the hydrological similarity among catchments. Weaker hydrological similarity among continental catchments results in larger variability in GHM‐forced LSTM, with the best performance in Siberia (NSE, 0.54) and the worst in North America (NSE, 0.10). However, the migration performance of GHM‐forced LSTM was significantly improved (NSE, 0.63) in ungauged basins when hydrological similarity was considered. This study stressed the advantages of GHM‐forced LSTM and due significance should be attached to hydrological similarities among catchments to improve hydrological prediction in ungauged catchments.