bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polycyclic aromatic hydrocarbon size tracers
Authors: Maragkoudakis A , Peeters E , Ricca A , Boersma C 
Published: July 2023

ABSTRACT
We examine the dependence of polycyclic aromatic hydrocarbon (PAH) band intensity ratios as a function of the average number of carbon atoms and assess their effectiveness as tracers for PAH size, utilizing the data, models, and tools provided by the NASA Ames PAH Infrared Spectroscopic Data base. To achieve this, we used spectra from mixtures of PAHs of different ionization fractions, following a size distribution. Our work, congruent with earlier findings, shows that band ratios that include the 3.3 μm PAH band provide the best PAH size tracers for small-to-intermediate sized PAHs. In addition, we find that band ratios that include the sum of the 15–20 μm PAH features (I$_{\Sigma _{15-20}}$) and the 6.2 or 7.7 μm bands also serve as good tracers for PAH size in the case of small-to-intermediate sized PAHs, for objects under a similar PAH size distribution as with the presented models. For different PAH size distributions, the application of a scaling factor to the I6.2/I$_{\Sigma _{15-20}}$ ratio can provide estimates for the size of the small-to-intermediate PAH population within sources. Employment of the I6.2/I$_{\Sigma _{15-20}}$ and I7.7/I$_{\Sigma _{15-20}}$ ratios can be of particular interest for JWST observations limited only to ∼5–28 μm MIRI(MRS) coverage.
An apparent positive relation between spin and orbital angular momentum in X-ray binaries
Authors: Yan Zhen , Zhang Wenda , Yu Wenfei 
Published: July 2023

ABSTRACT
The origin of current angular momentum (AM) of the black hole (BH) in X-ray binary (XRB) is still unclear, which is related with the birth and/or the growth of the BH. Here, we collect the spin parameters a* measured in BH XRBs and find an apparent bimodal distribution centered at ∼ 0.17 and 0.83. We find a positive relation between the spin parameter and the orbital period/orbital separation through combining distinct XRB categories, including neutron star (NS) low-mass X-ray binaries (LMXBs), Roche lobe overflow (RLOF) BH XRBs, and wind-fed BH XRBs. It seems that the AM of the compact star and the binary orbit correlates by combining the different XRB systems. These positive relations imply that accretion process is a common mechanism for spinning up the compact star in these diverse XRB systems. We infer that the low and high spin BH XRBs may experience different evolution and accretion history, which corresponds to the bimodal distribution of the BH spin parameters. The low spin BHs (a* &lt; 0.3) are similar to the NS LMXBs, the compact star of which is spun-up by the low-level accretion, and the high spin BHs (a* &gt; 0.5) had experienced a short hypercritical accretion ($\gg \dot{M}_\mathrm{Edd}$) period, during which, the BH spin dramatically increased.
A new pulsar candidate in 47 Tucanae discovered with MeerKAT imaging
Authors: Heywood Ian 
Published: July 2023

ABSTRACT
MeerKAT imaging of the globular cluster 47 Tucanae (47 Tuc) reveals 1.28 GHz continuum emission at the locations of 20 known millisecond pulsars (MSPs). We use time series and spectral imaging to investigate the image-domain characteristics of the MSPs, and search for previously unknown sources of interest. The MSPs exhibit a range of differences in their temporal and spectral properties compared the general background radio source population. Temporal variability differs strongly from pulsar to pulsar, some appearing to vary randomly on 15 min time-scales, others varying coherently by factors of &gt;10 on time-scales of hours. The error in the typical power law fit to the spectrum emerges as a powerful parameter for indentifying the MSPs. This behaviour is likely due to differing diffractive scintillation conditions along the sightlines to the MSPs. One MSP exhibits tentative periodic variations that are consistent with modulation due the orbit of an eclipsing binary system. One radio source has spectro-temporal properites closely resembling those of the MSP population in the cluster, and we report its position as a candidate new MSP, or alternatively an interferometric localization of one of six MSPs which do not yet have an accurate position from the timing solutions.
Zn deficiency disrupts Cu and S homeostasis in Chlamydomonas resulting in over accumulation of Cu and Cysteine
Authors: Strenkert Daniela , Schmollinger Stefan , Hu Yuntao , Hofmann Christian , Holbrook Kristen , Liu Helen W , Purvine Samuel O , Nicora Carrie D , Chen Si , Lipton Mary S , Northen Trent R , Clemens Stephan , Merchant Sabeeha S 
Published: July 2023

AbstractGrowth of Chlamydomonas reinhardtii in zinc (Zn) limited medium leads to disruption of copper (Cu) homeostasis, resulting in up to 40-fold Cu over-accumulation relative to its typical Cu quota. We show that Chlamydomonas controls its Cu quota by balancing Cu import and export, which is disrupted in a Zn deficient cell, thus establishing a mechanistic connection between Cu and Zn homeostasis. Transcriptomics, proteomics and elemental profiling revealed that Zn-limited Chlamydomonas cells up-regulate a subset of genes encoding “first responder” proteins involved in sulfur (S) assimilation and consequently accumulate more intracellular S, which is incorporated into L-cysteine, γ-glutamylcysteine, and homocysteine. Most prominently, in the absence of Zn, free L-cysteine is increased ∼80-fold, corresponding to ∼2.8 × 109 molecules/cell. Interestingly, classic S-containing metal binding ligands like glutathione and phytochelatins do not increase. X-ray fluorescence microscopy showed foci of S accumulation in Zn-limited cells that co-localize with Cu, phosphorus and calcium, consistent with Cu-thiol complexes in the acidocalcisome, the site of Cu(I) accumulation. Notably, cells that have been previously starved for Cu do not accumulate S or Cys, causally connecting cysteine synthesis with Cu accumulation. We suggest that cysteine is an in vivo Cu(I) ligand, perhaps ancestral, that buffers cytosolic Cu.
Glutathione-related antioxidant defence, DNA damage, and DNA repair in patients suffering from post-COVID conditions
Authors: Kankaya Selin , Yavuz Fatih , Tari Alper , Aygun Ahmet Bera , Gunes Esra Gizem , Bektan Kanat Bahar , Ulugerger Avci Gulru , Yavuzer Hakan , Dincer Yildiz 
Published: July 2023

AbstractPost-COVID conditions are defined as the continuation of the symptoms of Coronavirus Disease 2019 (COVID-19) 3 months after the initial Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, with no other explanation. Post-COVID conditions are seen among 30%–60% of patients with asymptomatic or mild forms of COVID-19. The underlying pathophysiological mechanisms of post-COVID conditions are not known. In SARS-CoV-2 infection, activation of the immune system leads to increased production of reactive oxygen molecules, depleted antioxidant reserve, and finally occurrence of oxidative stress. In oxidative stress conditions, DNA damage increases and DNA repair systems impair. In this study, glutathione (GSH) level, glutathione peroxidase (GPx) activity, 8-hydroxydeoxyguanosine (8-OHdG) level, basal, induced, and post-repair DNA damage were investigated in individuals suffering from post-COVID conditions. In the red blood cells, GSH levels and GPx activities were measured with a spectrophotometric assay and a commercial kit. Basal, in vitro H2O2 (hydrogen peroxide)-induced, and post-repair DNA damage (DNA damage after a repair incubation following H2O2-treatment, in vitro) were determined in lymphocytes by the comet assay. The urinary 8-OHdG levels were measured by using a commercial ELISA kit. No significant difference was found between the patient and control groups for GSH level, GPx activity, and basal and H2O2-induced DNA damage. Post-repair DNA damage was found to be higher in the patient group than those in the control group. Urinary 8-OHdG level was lower in the patient group compared to the control group. In the control group, GSH level and post-repair DNA damage were higher in the vaccinated individuals. In conclusion, oxidative stress formed due to the immune response against SARS-COV-2 may impair DNA repair mechanisms. Defective DNA repair may be an underlying pathological mechanism of post-COVID conditions.
Nonstructural maintenance of chromatin condensin I complex subunit G promotes the progression of glioblastoma by facilitating Poly (ADP-ribose) polymerase 1-mediated E2F1 transactivation
Authors: Hou Jianbing , Huang Pan , Xu Minghao , Wang Hao , Shao Yaqian , Weng Xuelian , Liu Yudong , Chang Hongbo , Zhang Li , Cui Hongjuan 
Published: July 2023

Abstract

Background
Nonstructural maintenance of chromatin condensin I complex subunit G (NCAPG), also known as non-structural maintenance of chromosomes condensin I complex subunit G, is mitosis-related protein that widely existed in eukaryotic cells. Increasing evidence has demonstrated that aberrant NCAPG expression was strongly associated with various tumors. However, little is known about the function and mechanism of NCAPG in glioblastoma (GBM).

Methods
The expression and prognostic value of NCAPG were detected in the clinical databases and tumor samples. The function effects of NCAPG downregulation or overexpression were evaluated in GBM cell proliferation, migration, invasion, and self-renewal in vitro and in tumor growth in vivo. The molecular mechanism of NCAPG was researched.

Results
We identified that NCAPG was upregulated in GBM and associated with poor prognosis. Loss of NCAPG suppressed the progression of GBM cells in vitro and prolonged survival in mouse models of GBM in vivo. Mechanistically, we revealed that NCAPG positively regulated E2F transcription factor 1 (E2F1) pathway activity. By directly interacting with Poly (ADP-ribose) polymerase 1, a co-activator of E2F1, and facilitating the PARP1-E2F1 interaction to activate E2F1 target gene expression. Intriguingly, we also discovered that NCAPG functioned as a downstream target of E2F1, which was proved by the ChIP and Dual-Luciferase results. Comprehensive data mining and immunocytochemistry analysis revealed that NCAPG expression was positively associated with the PARP1/E2F1 signaling axis.

Conclusions
Our findings indicate that NCAPG promotes GBM progression by facilitating PARP1-mediated E2F1 transactivation, suggesting that NCAPG is a potential target for anticancer therapy.
Calibration of local chemical pressure by optical probe
Authors: Zhou Xiao , Zhao Mei-Huan , Yao Shan-Ming , Dong Hongliang , Wang Yonggang , Chen Bin , Xing Xianran , Li Man-Rong 
Published: July 2023

ABSTRACT
Chemical stabilization of a high-pressure metastable state is a major challenge for the development of advanced materials. Although chemical pressure (Pchem) can effectively simulate the effect of physical pressure (Pphy), experimental calibration of the pressure passed to local structural motifs, denoted as local chemical pressure (Pchem-Δ) which significantly governs the function of solid materials, remains absent due to the challenge of probing techniques. Here we establish an innovative methodology to experimentally calibrate the Pchem-Δ and build a bridge between Pchem and Pphy via an optical probe strategy. Site-selective Bi3+-traced REVO4 (RE = Y, Gd) is adopted as a prototype to introduce Bi3+ optical probes and on-site sense of the Pchem-Δ experienced by the REO8 motif. The cell compression of RE0.98Bi0.02VO4 under Pphy is chemically simulated by smaller-ion substitution (Sc3+ → RE3+) in RE0.98-xScxBi0.02VO4. The consistent red shift (Δλ) of the emission spectra of Bi3+, which is dominated by locally pressure-induced REO8 dodecahedral variation in RE0.98Bi0.02VO4 (Pphy) and RE0.98-xScxBi0.02VO4 (Pchem-Δ), respectively, is evidence of their similar pressure-dependent local structure evolution. This innovative Δλ-based experimental calibration of Pchem-Δ in the crystal-field dimension portrays the anisotropic transmission of Pchem to the local structure and builds a bridge between Pchem-Δ and Pphy to guide a new perspective for affordable and practical interception of metastable states.
Self-poisoning by E-cigarette and E-liquids: National Reports to French Poison Control Centers from July 2019 to December 2020: VIGIlance and VAPE: The VIGIVAPE Study
Authors: Franchitto Nicolas , Bloch Juliette , Solal Cécilia ,   French PCC Research Group, Pélissier Fanny 
Published: July 2023

Abstract

Introduction
Exposure to e-cigarette liquids, whether intentional or accidental, might lead to adverse events. This study aimed to describe the prevalence and characteristics of exposures to e-liquids reported to French Poison Control Centers.

Methods
All e-liquids exposure cases reported to French Poison Control Centers from July 1, 2019, to December 31, 2020, were reviewed. Information was collected about the patient’s characteristics, exposure circumstances, management and outcome.

Results
About 919 cases of exposure to e-liquids were reported. Ages ranged from one month to 89 years, with a mean age of 16.6 ± 18.6 years and a median age of 4 years. The highest number of exposures—50.7%—concerned infants (0–4 years), 3.1% children (5–11 years), 5.9% adolescents (12–17 years), and 40.1% of cases concerned adults. The majority of cases were accidental (95.0%). Intentional exposures (4.9%) were mainly observed in patients older than 12 years of age (P &lt; 0.001). The route of exposure was ingestion in 73.7% of the cases. A total of 455 exposures showed no symptoms or signs related to poisoning. High nicotine concentration in e-liquids was associated with an increase in hospital management (Odds-ratio from 1.77 to 2.60).

Conclusion
Involuntary exposures to e-liquids occurred more often in children under the age of five, mainly by ingestion. Unlike intentional ingestions, unintentional ingestions rarely resulted in severe adverse events. These findings highlight the importance of ongoing surveillance to prevent such exposures and associated injuries, emphasizing the need for effective regulation of these products.
How Does Tobacco Use Affect the Cognition of Older Adults? A Propensity Score Matching Analysis Based on a Large-Scale Survey
Authors: Singh Lucky , Chandra Rishita , Pai Manacy , Singh Arpit , Mazumdar Sumit , Singh Balhara Yatan Pal , Singh Prashant Kumar , Singh Shalini 
Published: July 2023

AbstractIntroductionTobacco is a well-established risk factor for cancer, but its association with other morbidities needs consideration. The low-income and middle-income countries (LMICs) with unprecedented demographic transformation lack evidence on tobacco use and its impact on cognitive health.Aims and MethodsUsing a propensity score matching approach, we utilized data from the Longitudinal Ageing Study of India. Study employed 1:1 nearest neighbor matching with the replacement methodology. We estimated the odds of the poor cognitive score and tobacco use among older adults based on five different models for ever tobacco user, former tobacco user, current tobacco user, current smokers, and current smokeless tobacco users with reference to never tobacco users.ResultsThe estimated average treatment effect for the treated and the untreated group has shown a higher likelihood of cognitive decline among ever (OR −0.26; 95%CI −0.43 to −0.09), current (OR −0.28; 95%CI −0.45 to −0.10), and former (OR −0.53; 95%CI −0.87 to −0.19) tobacco users compared to never tobacco users. The finding further suggests the odds of lower cognitive scores among older adults who were smokers (OR −0.53; 95%CI −0.87 to −0.19) and smokeless tobacco users (OR −0.22; 95%CI −0.43 to −0.01) as compared to never tobacco users.ConclusionsInterventions designed to prevent the incidence of cognitive impairment should focus on limiting the use of tobacco. Strategies under the tobacco-free generation initiative should be amplified in order to prevent future generations from productivity loss, premature ageing and to promote healthy aging.ImplicationsEvidence of a definitive association between tobacco consumption and cognition among older adults is sporadic in LMICs. Though tobacco is a risk factor for various diseases including cancer, the extent of its impact on cognitive health among the older population is limited. This study contributes to the existing literature by highlighting poor cognitive outcomes among older adults who smoke tobacco and/or consume smokeless tobacco as compared to never-tobacco users. Our findings emphasize the need to accelerate programmes related to tobacco-free generation in LMICs to reach a higher quality of life and healthy aging in pursuit of achieving the sustainable development goal of “good health and well-being.”
Substitutes or complements: a budget-based analysis of the relationship between donating and volunteering
Authors: Voorintholt Lieke 
Published: July 2023

Abstract
Are charitable gifts of money and time substitutes or complements? The answer to this question would benefit non-profit organizations and governments aiming to maximize charitable gifts, but previous research has not yet delivered a final conclusion. Therefore, I introduce an alternative approach to this question that focuses on variation in individuals’ budgets instead of previously used variation in the price of giving. For this purpose, I develop a theoretical model of charitable giving in which individuals are constrained by two budgets indicating their available money and time. My derivations show that the cross-budget effects can identify the relationship between donating and volunteering. Consequently, I empirically estimate the effect of time on donations using longitudinal survey data of Dutch individuals. My estimates (albeit insignificant) suggest that donating and volunteering are substitutes. This result would be in line with some previous experimental evidence, but additional applications are needed to strengthen this conclusion.
Molecular Characterization of Trypanosoma cruzi Reactivation and Follow-up in a Case Series of People With HIV
Authors: Fernandez Marisa Liliana , Albizu Constanza Lopez , Nicita Diego , Besuschio Susana , Giomi Cinthia , Biondi María Laura , Leguizamón María Susana , Garcia Julian , Corti Marcelo , Schijman Alejandro , Burgos Juan Miguel 
Published: July 2023

Abstract
We characterize Trypanosoma cruzi infections from blood and cerebrospinal fluid samples in a case series of people with human immunodeficiency virus and Chagas disease. We identify different infecting T. cruzi populations, highlighting the usefulness of real-time polymerase chain reaction for Chagas disease reactivation diagnosis and evaluation of treatment response.
Adverse effects of 21 antidepressants on sleep during acute-phase treatment in major depressive disorder: a systemic review and dose-effect network meta-analysis
Authors: Zhou Shuzhe , Li Pei , Lv Xiaozhen , Lai Xuefeng , Liu Zuoxiang , Zhou Junwen , Liu Fengqi , Tao Yiming , Zhang Meng , Yu Xin , Tian Jingwei , Sun Feng 
Published: July 2023

Abstract

Study Objectives
Sleep-related adverse effects during acute treatment with antidepressants undermine adherence and impede remission. We aimed to address subtypes of sleep-related adverse effects and depict the relationship between dose and sleep-related adverse events.

Methods
We searched PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science for double-blind randomized controlled trials of depression published before April 30th, 2023. Eligible studies reporting sleep-related adverse effects during short-term monotherapy were included. The odds ratios (ORs) for sleep-related adverse effects were addressed with network meta-analysis. A Bayesian approach was used to depict the dose-effect relationship. Heterogeneity among studies was assessed using the τ2 and I2 statistics. Sensitivity analyses were performed without studies featuring high risk of bias.

Results
Studies with 64 696 patients were examined from 216 trials. Compared to placebo, 13 antidepressants showed higher ORs for somnolence, of which fluvoxamine (OR = 6.32; 95% CI: 3.56 to 11.21) ranked the top. Eleven had higher risks for insomnia, reboxetine ranked the top (OR = 3.47; 95% CI: 2.77 to 4.36). The dose-effect relationships curves between somnolence or insomnia and dose included linear shape, inverted U-shape, and other shapes. There was no significant heterogeneity among individual studies. The quality of evidence for results in network meta-analyses was rated as very low to moderate by Grading of Recommendations Assessment, Development, and Evaluation.

Conclusions
Most antidepressants had higher risks for insomnia or somnolence than placebo. The diverse relationship curves between somnolence or insomnia and dose of antidepressants can guide clinicians to adjust the doses. These findings suggest clinicians pay more attention to sleep-related adverse effects during acute treatment with antidepressants.
LA Micro Group (UK) Ltd v LA Micro Group Inc [2023] EWCA Civ 214—A (sub-)trust for thee but not for me
Authors: Nam Seongwook , Yean Alexander 
Published: July 2023

Abstract
In LA Micro Group (UK) Ltd v LA Micro Group Inc [2023] EWCA Civ 214, the Court held that under an express trust with A as trustee and B as beneficiary, a constructive sub-trust could arise with B as sub-trustee and A as beneficiary under the sub-trust, resulting in B dropping out of the picture and the legal title and beneficiary interest merging in A. It is argued that the Court’s reasoning is conceptually untenable given the inherent instability of a circular sub-trust structure; the better view is that the remedy given was a sui generis equitable order.
Small artery remodeling and stiffening in deoxycorticosterone acetate-salt hypertensive rats involves the interaction between endogenous ouabain/Na+K+-ATPase/cSrc signaling
Authors: Tomazelli Caroline Aparecida , Ishikawa Flávia Midori , Couto Gisele Kruger , Parente Juliana Montenegro , Castro Michele Mazzaron de , Xavier Fabiano Elias , Rossoni Luciana Venturini 
Published: July 2023

Objective:
Endogenous ouabain (EO) increases in some patients with hypertension and in rats with volume-dependent hypertension. When ouabain binds to Na+K+-ATPase, cSrc is activated, which leads to multieffector signaling activation and high blood pressure (BP). In mesenteric resistance arteries (MRA) from deoxycorticosterone acetate (DOCA)-salt rats, we have demonstrated that the EO antagonist rostafuroxin blocks downstream cSrc activation, enhancing endothelial function and lowering oxidative stress and BP. Here, we examined the possibility that EO is involved in the structural and mechanical alterations that occur in MRA from DOCA-salt rats.

Methods:
MRA were taken from control, vehicle-treated DOCA-salt or rostafuroxin (1 mg/kg per day, for 3 weeks)-treated DOCA-salt rats. Pressure myography and histology were used to evaluate the mechanics and structure of the MRA, and western blotting to assess protein expression.

Results:
DOCA-salt MRA exhibited signs of inward hypertrophic remodeling and increased stiffness, with a higher wall:lumen ratio, which were reduced by rostafuroxin treatment. The enhanced type I collagen, TGFβ1, pSmad2/3Ser465/457/Smad2/3 ratio, CTGF, p-SrcTyr418, EGFR, c-Raf, ERK1/2 and p38MAPK protein expression in DOCA-salt MRA were all recovered by rostafuroxin.

Conclusion:
A process combining Na+K+-ATPase/cSrc/EGFR/Raf/ERK1/2/p38MAPK activation and a Na+K+-ATPase/cSrc/TGF-1/Smad2/3/CTGF-dependent mechanism explains how EO contributes to small artery inward hypertrophic remodeling and stiffening in DOCA-salt rats. This result supports the significance of EO as a key mediator for end-organ damage in volume-dependent hypertension and the efficacy of rostafuroxin in avoiding remodeling and stiffening of small arteries.