bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is cognitive control of perception and action via attentional focus moderated by motor imagery?
Authors: Bazgir Behzad , Shamseddini Alireza , Hogg Jennifer A. , Ghadiri Farhad , Bahmani Moslem , Diekfuss Jed A. 
Published: January 2023

AbstractMotor imagery (MI) has emerged as an individual factor that may modulate the effects of attentional focus on motor skill performance. In this study, we investigated whether global MI, as well as its components (i.e., kinesthetic MI, internal visual MI, and external visual MI) moderate the effect of attentional focus on performance in a group of ninety-two young adult novice air-pistol shooters (age: M = 21.87, SD = 2.54). After completing the movement imagery questionnaire-3 (MIQ-3), participants were asked to complete a pistol shooting experiment in three different attentional focus conditions: (1) No focus instruction condition (control condition with no verbal instruction) (2) an internal focus instruction condition, and (3) an external focus condition. Shot accuracy, performance time, and aiming trace speed (i.e., stability of hold or weapon stability) were measured as the performance variables. Results revealed that shot accuracy was significantly poorer during internal relative to control focus condition. In addition, performance time was significantly higher during external relative to both control and internal condition. However, neither global MI, nor its subscales, moderated the effects of attentional focus on performance. This study supports the importance of attentional focus for perceptual and motor performance, yet global MI and its modalities/perspectives did not moderate pistol shooting performance. This study suggests that perception and action are cognitively controlled by attentional mechanisms, but not motor imagery. Future research with complementary assessment modalities is warranted to extend the present findings.
CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
Authors: Park Jong-Whi , Kilic Omer , Deo Minh , Jimenez-Cowell Kevin , Demirdizen Engin , Kim Hyunggee , Turcan Şevin 
Published: January 2023

AbstractCapicua (CIC) is an important downstream molecule of RTK/RAS/MAPK pathway. The regulatory mechanism of CIC underlying tumorigenesis in oligodendroglioma, where CIC is frequently mutated, has yet to be fully elucidated. Using patient-derived glioma lines, RNA-sequencing and bioinformatic analysis of publicly available databases, we investigated how CIC loss- or gain-of-function regulates its downstream targets, cell proliferation and glutamate release. Our results indicate an increased frequency of CIC truncating mutations in oligodendroglioma during progression. In vitro, CIC modulation had a modest effect on cell proliferation in glioma lines, and no significant changes in the expression of ETV1, ETV4 and ETV5. Transcriptional repression of known CIC targets was observed in gliomas expressing non-phosphorylatable CIC variant on Ser173 which was unable to interact with 14-3-3. These data outline a mechanism by which the repressor function of CIC is inhibited by 14-3-3 in gliomas. Using transcriptional profiling, we found that genes related to glutamate release were upregulated because of CIC depletion. In addition, loss of CIC leads to increased extracellular glutamate. Consistent with this, CIC restoration in an oligodendroglioma line reduced the levels of extracellular glutamate, neuronal toxicity and xCT/SLC7A11 expression. Our findings may provide a molecular basis for the prevention of glioma-associated seizures.
Soft actuators-based skill training wearables: a review on the interaction modes, feedback types, VR scenarios, sensors utilization and applications
Authors: Ramasamy Priyanka , Calderon-Sastre Enrique , Renganathan Gunarajulu , Das Swagata , Kurita Yuichi 
Published: January 2023

AbstractDexterity training helps improve our motor skills while engaging in precision tasks such as surgery in the medical field and playing musical instruments. In addition, post-stroke recovery also requires extensive dexterity training to recover the original motor skills associated with the affected portion of the body. Recent years have seen a rise in the usage of soft-type actuators to perform such training, giving higher levels of comfort, compliance, portability, and adaptability. Their capabilities of performing high dexterity and safety enhancement make them specific biomedical applications and serve as a sensitive tools for physical interaction. The scope of this article discusses the soft actuator types, characterization, sensing, and control based on the interaction modes and the 5 most relevant articles that touch upon the skill improvement models and interfacing nature of the task and the precision it demands. This review attempts to report the latest developments that prioritize soft materials over hard interfaces for dexterity training and prospects of end-user satisfaction.
Multiscale spectroscopic analysis of lipids in dimorphic and oleaginous Mucor circinelloides accommodate sustainable targeted lipid production
Authors: Shapaval V. , Deniset-Besseau A. , Dubava D. , Dzurendova S. , Heitmann Solheim J. , Kohler A. 
Published: January 2023

Abstract
Background
Oleaginous fungi have versatile metabolism and able to transform a wide range of substrates into lipids, accounting up to 20–70% of their total cell mass. Therefore, oleaginous fungi are considered as an alternative source of lipids. Oleaginous fungi can accumulate mainly acyl glycerides and free fatty acids which are localized in lipid droplets. Some of the oleaginous fungi possessing promising lipid productivity are dimorphic and can exhibit three cell forms, flat hyphae, swollen hyphae and yeast-like cells. To develop sustainable targeted fungal lipid production, deep understanding of lipogenesis and lipid droplet chemistry in these cell forms is needed at multiscale level. In this study, we explored the potential of infrared spectroscopy techniques for examining lipid droplet formation and accumulation in different cell forms of the dimorphic and oleaginous fungus Mucor circinelloides.

Results
Both transmission- and reflectance-based spectroscopy techniques are shown to be well suited for studying bulk fungal biomass. Exploring single cells with infrared microspectroscopy reveals differences in chemical profiles and, consequently, lipogenesis process, for different cell forms. Yeast-like cells of M. circinelloides exhibited the highest absorbance intensities for lipid-associated peaks in comparison to hyphae-like cell forms. Lipid-to-protein ratio, which is commonly used in IR spectroscopy to estimate lipid yield was the lowest in flat hyphae. Swollen hyphae are mainly composed of lipids and characterized by more uniform distribution of lipid-to-protein concentration. Yeast-like cells seem to be comprised mostly of lipids having the largest lipid-to-protein ratio among all studied cell forms. With infrared nanospectroscopy, variations in the ratios between lipid fractions triglycerides and free fatty acids and clear evidence of heterogeneity within and between lipid droplets are illustrated for the first time.

Conclusions
Vibrational spectroscopy techniques can provide comprehensive information on lipogenesis in dimorphic and oleaginous fungi at the levels of the bulk of cells, single cells and single lipid droplets. Unicellular spectra showed that various cell forms of M. circinelloides differs in the total lipid content and profile of the accumulated lipids, where yeast-like cells are the fatty ones and, therefore, could be considered as preferable cell form for producing lipid-rich biomass. Spectra of single lipid droplets showed an indication of possible droplet-to-droplet and within-droplet heterogeneity.
Prevalence and associated factors of delay antenatal care at public health institutions in Gondar city, Northwest Ethiopia, 2021: a cross-sectional study
Authors: Abera Eshetu , Azanaw Jember , Tadesse Tsion , Endalew Mastewal 
Published: January 2023

Abstract
Background
Antenatal care is critical for women’s and unborn children’s health. In Ethiopia there is still a delay in getting antenatal care visit in the first trimester as recommended by the World Health Organization. Therefore, the purpose of this study was to assess the prevalence of delayed antenatal care visits and associated factors among pregnant women who attend antenatal care at a public health facility in Gondar town, Northwest Ethiopia.

Methods
An institutional-based cross-sectional study was conducted between August 20 to September 15/2021. A simple random sampling technique was used to select 392 women. Data were collected using a pre-tested structured questionnaire through a face-to-face interview. Epi Info version 7 and SSPS 26.0 were used for data entry and further analysis. Descriptive statistics and multivariable logistic regression analyses were performed. An adjusted odds ratio with 95% confidence interval at p-value < 0.05 was declared that the outcome can be statistically significant.

Results
A total of 392 study participants with a response rate of 98% were participated. The mean age of study participants was 29.1 ± 6.5 (SD) years. In this study, the prevalence of delay antenatal care was 63.8%( 95% CI: 58.9, 68.9). Age (Adjusted odds ratio = 0.51; 95% CI: 0.28, 0.93), types of health facilities (Adjusted odds ratio = 2.02; 95% CI :( 1.12, 3.64), and satisfaction with health service (Adjusted odds ratio = 3.23, 95%CI: (2.02, 5.16) were significantly associated with delay antenatal care.

Conclusion
The current study found high prevalence of delay antenatal care. Age between 31 and 34, hospital health facility and satisfaction with health service quality were associated factors for delay antenatal care visit. To begin antenatal care follow-up in the recommended time frame, a collaborative effort between the Minister of Health, health facilities, and relevant stakeholders is needed.
The linkage between Bitcoin and foreign exchanges in developed and emerging markets
Authors: BenSaïda Ahmed 
Published: January 2023

AbstractThis study investigates the connectedness between Bitcoin and fiat currencies in two groups of countries: the developed G7 and the emerging BRICS. The methodology adopts the regular (R)-vine copula and compares it with two benchmark models: the multivariate t copula and the dynamic conditional correlation (DCC) GARCH model. Moreover, this study examines whether the Bitcoin meltdown of 2013, selloff of 2018, COVID-19 pandemic, 2021 crash, and the Russia-Ukraine conflict impact the linkage with conventional currencies. The results indicate that for both currency baskets, R-vine beats the benchmark models. Hence, the dependence is better modeled by providing sufficient information on the shock transmission path. Furthermore, the cross-market linkage slightly increases during the Bitcoin crashes, and reaches significant levels during the 2021 and 2022 crises, which may indicate the end of market isolation of the virtual currency.
Fatal peritoneal dialysis-associated peritonitis caused by Mycobacterium mageritense: a case report with review
Authors: Hashimoto Nobuhiro , Kani Nao , Makino Shuzo , Naka Tomoya , Miyakawa Hiromitsu , Okamoto Kazuhiro , Uwatoko Ryuta , Bessho Saki , Iio Rei , Ueda Yoshiyasu , Hayashi Terumasa 
Published: January 2023

Abstract
Background
Peritonitis is a serious and potentially fatal complication of peritoneal dialysis. We report a case of fatal peritonitis caused by Mycobacterium mageritense that was detected for the first time in peritonitis.

Case presentation
A male patient in his 60 s undergoing peritoneal dialysis was admitted for catheter diversion with exit-site renewal. The patient had a refractory exit-site infection. Mycobacterial culture was not performed at the exit site prior to admission. After the surgery, the patient developed a fever, and a cloudy effluent was observed. Various antibiotics, including anti-tuberculosis drugs, were administered; however, his symptoms did not improve. The catheter was removed on the thirty-seventh day of admission. Bacteria positive for Ziehl–Neelsen staining were found in the peritoneal sample collected during the surgery. Since nontuberculous mycobacteria were considered the cause of peritonitis, the patient was administered imipenem/cilastatin, amikacin, and clarithromycin. However, he died of septic shock on the fifty-first day after admission. Mycobacterium mageritense was detected in the ascites culture after death.

Conclusion
This is, to our knowledge, the first report of peritonitis caused by Mycobacterium mageritense. In patients undergoing peritoneal dialysis, when a refractory exit-site infection is observed, mycobacterial culture is necessary to prevent the development of peritonitis.
Comparative demography, population projection, functional response and host age preference behavior of the parasitoid Goniozus legneri on two lepidopterous insect hosts
Authors: Ehteshami Fatemeh , Aleosfoor Maryam , Allahyari Hossein , Kavousi Aurang , Fekrat Lida 
Published: January 2023

Abstract
Background
This study was conducted to investigate life table characteristics of the parasitoid species, Goniozus legneri Gordh (Hymenoptera: Bethylidae), a major gregarious larval ecto-parasitoids of the carob moth, Ectomyelois ceratoniae Zeller (Lep.: Pyralidae). Demographic parameters of G. legneri reared on two hosts, the carob moth and the flour moth, Ephestia kuehniella (Zeller) (Lepidoptera: Pyralidae), were studied under laboratory conditions using age-stage, two-sex life table. Host stage preference and the functional response of this parasitoid were also determined.

Results
The duration of the immature period, adult pre-ovipositional period and total pre-ovipositional period of G. legneri reared on E. kuehniella was significantly longer than that of those reared on E. ceratoniae, while fecundity and ovipositional days of the wasp were greater/longer in females reared on E. ceratoniae. There were also significant differences in intrinsic and finite rates of increase and mean generation time between wasp parasitoid reared on two hosts. Moreover, population projection indicated that the G. legneri population can grow swifter when reared on E. ceratoniae than on E. kuehniella. Based on the experiments conducted to determine the larval stage preferences of G. legneri, for both hosts, larger larvae were more preferred stages compared to smaller ones, thereby fulfilling the optimal oviposition theory. The functional responses of G. legneri to different population densities of E. kuehniella two last instar larvae were determined as type III at 25 °C and 60% RH.

Conclusion
The results offer valuable information on some life history attributes of G. legneri. Although G. legneri performed better on E. ceratoniae larvae than on E. kuehniella, as the use of E. ceratoniae larvae as the main host in rearing of G. legneri might be a laborious process and can increase the production costs, E. kuehniella can be used as an alternative host. Further studies are required under greenhouse and field conditions for effective use of this biocontrol agent against the carob moth.
A p.Val412Serfs pathogenic variant associated with Wolfram-like syndrome and leukodystrophy
Authors: Kocaaga Ayca , Yimenicioglu Sevgi , Bayav Murat 
Published: January 2023

Abstract
Background
Wolfram syndrome is due to a mutation of the WFS1 gene that codes for the transmembrane protein wolframin. This protein is located in the endoplasmic reticulum and is expressed at higher concentrations in the beta cells of pancreatic islets and the brain. The term "Wolfram syndrome spectrum" is often used because of its genetic and clinical heterogeneity. Disorders associated with the WFS1 gene include Wolfram syndrome following an autosomal recessive inheritance pattern and Wolfram-like syndrome following an autosomal dominant inheritance pattern, and congenital cataract. Here, we report a case with Wolfram-like syndrome presented with bilateral congenital cataract, optic atrophy, nystagmus, ataxia, mild intellectual disability, epilepsy and leukodystrophy.

Case report
Magnetic resonance imaging (MRI) showed bilateral cerebral T2 and flair hyperintensities that causes diffusion restriction in some areas with hypoperfusion. Bilateral T2 cerebellar central white matter hyperintensities and atrophy of brain stem were revealed by the brain MRI. There was also found evidence of a proximal cervical cord lesion and syrinx cavity in the vertebral MRI. The heterozygous frame-shift (c.1230_1233delCTCT; p.Val412Serfs) mutation in the WFS1 gene. This heterozygous pathogenic variant in the WFS1 gene was identified in both the father and grandmother.

Conclusions
To our knowledge, this is a novel Wolfram-like syndrome-related phenotype. This case report broadens the currently known phenotypic presentations of Wolfram-like syndrome and suggests that the p.Val412Serfs variant in the WFS1 gene may be associated with syrinx cavity and leukodystrophy.
Chemical constituents of industrial hemp roots and their anti-inflammatory activities
Authors: Huang Shijie , Li Huifang , Xu Jun , Zhou Huihao , Seeram Navindra P. , Ma Hang , Gu Qiong 
Published: January 2023

Abstract
Objective
Although the chemical constituents of the aerial parts of Cannabis have been extensively studied, phytochemicals of Cannabis roots are not well characterized. Herein, we investigated the chemical constituents of industrial hemp (Cannabis sativa L.) roots and evaluated the anti-inflammatory activities of phytochemicals isolated from the hemp roots extract.

Methods
An ethyl acetate extract of hemp roots was subjected to a combination of chromatographic columns to isolate phytochemicals. The chemical structures of the isolates were elucidated based on spectroscopic analyses (by nuclear magnetic resonance and mass spectrometry). The anti-inflammatory effects of phytochemicals from hemp roots were evaluated in an anti-inflammasome assay using human monocyte THP-1 cells.

Results
Phytochemical investigation of hemp roots extract led to the identification of 32 structurally diverse compounds including six cannabinoids (1–6), three phytosterols (26–28), four triterpenoids (22–25), five lignans (17–21), and 10 hydroxyl contained compounds (7–16), three fatty acids (29–31), and an unsaturated chain hydrocarbon (32). Compounds 14–21, 23, 27, and 32 were identified from the Cannabis species for the first time. Cannabinoids (1–5) reduced the level of cytokine tumor necrosis-alpha (by 38.2, 58.4, 47.7, 52.2, and 56.1%, respectively) and 2 and 5 also decreased the interleukin-1β production (by 42.2 and 92.4%, respectively) in a cell-based inflammasome model. In addition, non-cannabinoids including 11, 13, 20, 25, 29, and 32 also showed selective inhibition of interleukin-1β production (by 23.7, 22.5, 25.6, 78.0, 24.1, 46.6, and 25.4%, respectively) in THP-1 cells.

Conclusion
The phytochemical constituent of a hemp roots extract was characterized and compounds from hemp roots exerted promising anti-inflammatory effects.
Sustainment of diverse evidence-informed practices disseminated in the Veterans Health Administration (VHA): initial development and piloting of a pragmatic survey tool
Authors: Reardon Caitlin M. , Damschroder Laura , Opra Widerquist Marilla A. , Arasim Maria , Jackson George L. , White Brandolyn , Cutrona Sarah L. , Fix Gemmae M. , Gifford Allen L. , DeLaughter Kathryn , King Heather A. , Henderson Blake , Vega Ryan , Nevedal Andrea L. 
Published: January 2023

Abstract
Background
There are challenges associated with measuring sustainment of evidence-informed practices (EIPs). First, the terms sustainability and sustainment are often falsely conflated: sustainability assesses the likelihood of an EIP being in use in the future while sustainment assesses the extent to which an EIP is (or is not) in use. Second, grant funding often ends before sustainment can be assessed.
The Veterans Health Administration (VHA) Diffusion of Excellence (DoE) program is one of few large-scale models of diffusion; it seeks to identify and disseminate practices across the VHA system. The DoE sponsors “Shark Tank” competitions, in which leaders bid on the opportunity to implement a practice with approximately 6 months of implementation support. As part of an ongoing evaluation of the DoE, we sought to develop and pilot a pragmatic survey tool to assess sustainment of DoE practices.

Methods
In June 2020, surveys were sent to 64 facilities that were part of the DoE evaluation. We began analysis by comparing alignment of quantitative and qualitative responses; some facility representatives reported in the open-text box of the survey that their practice was on a temporary hold due to COVID-19 but answered the primary outcome question differently. As a result, the team reclassified the primary outcome of these facilities to Sustained: Temporary COVID-Hold. Following this reclassification, the number and percent of facilities in each category was calculated. We used directed content analysis, guided by the Consolidated Framework for Implementation Research (CFIR), to analyze open-text box responses.

Results
A representative from forty-one facilities (64%) completed the survey. Among responding facilities, 29/41 sustained their practice, 1/41 partially sustained their practice, 8/41 had not sustained their practice, and 3/41 had never implemented their practice. Sustainment rates increased between Cohorts 1–4.

Conclusions
The initial development and piloting of our pragmatic survey allowed us to assess sustainment of DoE practices. Planned updates to the survey will enable flexibility in assessing sustainment and its determinants at any phase after adoption. This assessment approach can flex with the longitudinal and dynamic nature of sustainment, including capturing nuances in outcomes when practices are on a temporary hold. If additional piloting illustrates the survey is useful, we plan to assess the reliability and validity of this measure for broader use in the field.
Modified Lateral Orbitotomy Approach to Lesions of the Orbital Apex, Superior Orbital Fissure, Cavernous Sinus, and Middle Cranial Fossa
Authors: Bounajem Michael T. , Rennert Robert C. , Budohoski Karol P. , Azab Mohammad , Karsy Michael , Couldwell William T. 
Published: January 2023

BACKGROUND:
The lateral orbitotomy approach (LOA) provides minimally invasive access to the orbit, cavernous sinus region, and middle cranial fossa. Orbital retraction with this approach can nonetheless injure orbital structures, causing unnecessary morbidity.

OBJECTIVE:
To describe our clinical experience with the modified LOA (mLOA), wherein the medial aspect of the lateral orbital wall posterior to the orbital rim is preserved.

METHODS:
This is a retrospective, single-institution case series of patients undergoing a mLOA for lesions of the orbital apex, superior orbital fissure, cavernous sinus, and middle cranial fossa. The dimensions and variance of selected anatomic parameters relevant to this approach (orbital rim–superior orbital fossa depth, lateral orbital wall angle) were also analyzed using computed tomography scans from 30 adult patients.

RESULTS:
Eight patients underwent a mLOA (mean age 54.0 ± 19.6 years; 3 males). Surgical targets included the superior orbital fissure (2; cavernoma and meningioma), sphenoid wing with or without the orbital apex (2; meningioma), cavernous sinus (2; rule out carcinoma and smooth muscle tumor), and anterior/mesial temporal lobe (2; cavernoma). Visual acuity/fields and diplopia was stable or improved in all patients postoperatively. One patient experienced a cerebrospinal fluid leak. On computed tomography analysis, the relevant bony anatomy displayed limited variability, with a mean orbital fossa depth of 42.7 ± 2.8 mm and a lateral orbital wall angle of 44.4° ± 2.7°.

CONCLUSION:
The mLOA can provide safe, minimally invasive access to select lesions of the orbital apex, superior orbital fissure, cavernous sinus, and middle cranial fossa. The operative corridor has relatively consistent bony anatomy.