bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of displacement prediction method for mountain tunnels showing time-dependence characteristics
Authors: Uda M , Nashimoto Y , Isago N 
Published: January 2023

Abstract
During construction of mountain tunnels or in service, the ground behavior may show time-dependence characteristics in the acceleration stage. In such cases, in order to quickly consider the scale of displacement suppression, a method that can easily predict future displacement is required. Therefore, we proposed a structural deteriorating type of the Voigt model (called “the D-Voigt model”) that incorporates the structural deterioration mechanism into the Voigt model. When the strain increases, this model assumes that the elastic modulus of the spring and the viscosity coefficient of the dashpot decrease. Three exact solutions are derived from the constitutive equations of this model. These exact solutions can express not only the ground behavior of the deceleration/convergence stage, but also the ground behavior of the constant-velocity stage and the acceleration stage. Next, through an example of actual data from the service tunnel, it was clarified that this model can reproduce measurement results showing time-dependence characteristics in the acceleration stage and is useful as a prediction method of future displacement. At the same time, we devised a method to identify the coefficient of this model from the measurement results and clarified that it is highly effective.
Experimental study of aging-induced cementation effect on permeability property of bentonites
Authors: Ito D. , Wang H. , Komine H. 
Published: January 2023

Abstract
In geological disposal for high-level radioactive waste, bentonites are planned to be used as the buffer material surrounding radioactive waste in Japan. Bentonite-based buffer material requires low water permeation for delaying contact between groundwater and the waste. Because of the extremely long half-lives of radionuclides of the waste, several barriers including the buffer material are designed to maintain workability of the geological disposal facility for tens of thousands of years. However, in the disposal circumstances with high water pressure, high temperature and various groundwater chemistries, occurrence of cementation and consequently property changes of the bentonite in the buffer are concerned. Few studies are available to understand the effect of cementation on bentonite properties because of the difficulties of simulating long-term alteration process experimentally. From the viewpoint of natural analogues, cementation process of the buffer may be regarded as part of formation process of bentonite ore. Thus, in this study, permeability tests were conducted on three kinds of Na-type bentonite ores with different geological ages from respectively, Japan, USA, and China to see the influence of cementation on permeability of bentonites. For comparison, undisturbed and reconstituted specimens were prepared. The results show that difference of hydraulic conductivities of the undisturbed and reconstituted specimens for each ore is less than one order, and this difference seems not to correlate with the geological age of the ores. From these results, the influence of cementation on the hydraulic properties of bentonite buffer seems small. It may also be a counteracted result by cementation effects in terms of restriction of the swelling of montmorillonite and blockage of water flow paths.
Thermally induced shear reactivation of critically-stressed smooth and rough granite fractures
Authors: Sun Changlun , Zhuang Li , Yoon Jeoung Seok , Min Ki-Bok 
Published: January 2023

Abstract
Many candidate geological repositories have been reported to have relatively high ratios of in-situ horizontal stress to vertical stress. There can be a substantial increase in the horizontal stress due to the thermal stress resulting from radioactive decay, and accordingly fractures – particular the shallowly dipping ones – could be reactivated. The associated permeability increase with fracture shear dilation and large fracture slip could threaten the long-term safety of the deep geological repository. In this study, we elaborately investigated fracture reactivation under the coupled thermo-mechanical loading based on laboratory experiments. Critically-stressed single fractures in ca. 100 mm cubic granite specimens were heated in the minimum principal stress direction, through setting a target temperature of 150 °C at the heating source. Expansion in the maximum principal stress direction was restricted. Sawcut, laser-marking, and tensile-splitting fractures with low to high joint surface roughness (JRC=0~13) were compared. Fracture slip and shear dilation were directly measured by using clip-on displacement transducers and the measurements were further validated by the digital image correlation analysis. Temperature is non-uniformly distributed in the rock, and decreases with the increasing distance to the heating source. Thermally induced fracture slip grows slowly (compared with the stick-slip) but progressively with the peak slip rate of 2.69 – 6.65× 10−2 μm/s in different test cases. Shear dilation during thermoshearing can be ignored in the sawcut fracture, and a tendency that shear dilation is higher for the fracture with a larger JRC was confirmed.
Developing small-diameter vascular grafts with human amniotic membrane: long-term evaluation of transplantation outcomes in a small animal model
Authors: Wang Bo , Wang Xiaolong , Kenneth Allen , Drena Alexander , Pacheco Arsenio , Kalvin Lindsey , Ibrahim EI-Sayed , Rossi Peter J , Thatcher Kaitlyn , Lincoln Joy 
Published: January 2023

Abstract
While current clinical utilization of large vascular grafts for vascular transplantation is encouraging, tissue engineering of small grafts still faces numerous challenges. This study aims to investigate the feasibility of constructing a small vascular graft from decellularized amniotic membranes (DAMs). DAMs were rolled around a catheter and each of the resulting grafts was crosslinked with (a) 0.1% glutaraldehyde; (b) 1-ethyl-3-(3-dimethylaminopropyl) crbodiimidehydro-chloride (20 mM)-N-hydroxy-succinimide (10 mM); (c) 0.5% genipin; and (d) no-crosslinking, respectively. Our results demonstrated the feasibility of using a rolling technique followed by lyophilization to transform DAM into a vessel-like structure. The genipin-crosslinked DAM graft showed an improved integrated structure, prolonged stability, proper mechanical property, and superior biocompatibility. After transplantation in rat abdominal aorta, the genipin-crosslinked DAM graft remained patent up to 16 months, with both endothelial and smooth muscle cell regeneration, which suggests that the genipin-crosslinked DAM graft has great potential to be implemented as a small tissue engineered graft for future vascular transplantation.
Variational Hamiltonian simulation for translational invariant systems via classical pre-processing
Authors: Mansuroglu Refik , Eckstein Timo , Nützel Ludwig , Wilkinson Samuel A , Hartmann Michael J 
Published: January 2023

Abstract
The simulation of time evolution of large quantum systems is a classically challenging and in general intractable task, making it a promising application for quantum computation. A Trotter–Suzuki approximation yields an implementation thereof, where a higher approximation accuracy can be traded for an increased gate count. In this work, we introduce a variational algorithm which uses solutions of classical optimizations to predict efficient quantum circuits for time evolution of translationally invariant quantum systems. Our strategy can improve upon the Trotter–Suzuki accuracy by several orders of magnitude. It translates into a reduction in gate count and hence gain in overall fidelity at the same algorithmic accuracy. This is important in noisy intermediate scale quantum-applications where the fidelity of the output state decays exponentially with the number of gates. The performance advantage of our classical assisted strategy can be extended to open boundaries with translational symmetry in the bulk. We can extrapolate our method to beyond classically simulatable system sizes, maintaining its total fidelity advantage over a Trotter–Suzuki approximation making it an interesting candidate for beyond classical time evolution.
Is dynapenic abdominal obesity a risk factor for cardiovascular mortality? A competing risk analysis
Authors: Ramírez Paula Camila , de Oliveira Dayane Capra , de Oliveira Máximo Roberta , de Souza Aline Fernanda , Luiz Mariane Marques , Delinocente Maicon Luís Bicigo , Steptoe Andrew , de Oliveira Cesar , da Silva Alexandre Tiago 
Published: January 2023

Abstract

Background
Dynapenic abdominal obesity has been shown as a risk factor for all-cause mortality in older adults. However, there is no evidence on the association between this condition and cardiovascular mortality.

Objective
We aimed to investigate whether dynapenic abdominal obesity is associated with cardiovascular mortality in individuals aged 50 and older.

Methods
A longitudinal study with an 8-year follow-up was conducted involving 7,030 participants of the English Longitudinal Study of Ageing study. Abdominal obesity and dynapenia were respectively defined based on waist circumference (&gt; 102 cm for men and &gt; 88 cm for women) and grip strength (&lt; 26 kg for men and &lt; 16 kg for women). The sample was divided into four groups: non-dynapenic/non-abdominal obesity (ND/NAO), non-dynapenic/abdominal obesity (ND/AO), dynapenic/non-abdominal obesity (D/NAO) and dynapenic/abdominal obesity (D/AO). The outcome was cardiovascular mortality. The Fine-Grey regression model was used to estimate the risk of cardiovascular mortality as a function of abdominal obesity and dynapenia status in the presence of competing events controlled by socio-demographic, behavioural and clinical variables.

Results
The risk of cardiovascular mortality was significantly higher in individuals with D/AO compared with ND/NAO (SHR 1.85; 95% CI: 1.15–2.97). D/NAO was also associated with cardiovascular mortality (SHR: 1.62; 95% CI: 1.08–2.44).

Conclusion
Dynapenic abdominal obesity is associated with cardiovascular mortality, with a larger effect size compared to dynapenia alone in individuals older than 50 years. Thus, prevention strategies and clinical interventions that enable mitigating the harmful effects of these conditions should be adopted to diminish such risk.
Physical frailty, adherence to ideal cardiovascular health and risk of cardiovascular disease: a prospective cohort study
Authors: Chen Liangkai , Li Xingbang , Lv Yanling , Tan Xiao , Zhong Victor W , Rong Shuang , Liu Gang , Liu Liegang 
Published: January 2023

Abstract

Background
longitudinal evidence concerning frailty phenotype and the risk of cardiovascular disease (CVD) remained insufficient, and whether CVD preventive strategies exert low CVD risk on frail adults is unclear.

Objectives
we aimed to prospectively evaluate the association of frailty phenotype, adherence to ideal cardiovascular health (CVH) and their joint associations with the risk of CVD.

Methods
a total of 314,093 participants from the UK Biobank were included. Frailty phenotype was assessed according to the five criteria of Fried et al.: weight loss, exhaustion, low physical activity, slow gait speed and low grip strength. CVH included four core health behaviours (smoking, physical activity and diet) and three health factors (weight, cholesterol, blood pressure and glycaemic control). The outcome of interest was incident CVD, including coronary heart disease, heart failure and stroke.

Results
compared with the non-frail people whose incident rate of overall CVD was 6.54 per 1,000 person-years, the absolute rate difference per 1,000 person-years was 1.67 (95% confidence interval, CI: 1.33, 2.02) for pre-frail and 5.00 (95% CI: 4.03, 5.97) for frail. The ideal CVH was significantly associated with a lower risk of all CVD outcomes. For the joint association of frailty and CVH level with incident CVD, the highest risk was observed among frailty accompanied by poor CVH with an HR of 2.92 (95% CI: 2.68, 3.18).

Conclusions
our findings indicate that physical frailty is associated with CVD incidence. Improving CVH was significantly associated with a considerable decrease in CVD risk, and such cardiovascular benefits remain for the frailty population.
Changes in symptom burden from 2019 to 2021 amongst community-dwelling older adults in Finland
Authors: Lehti Tuuli E , Knuutila Mia , Öhman Hanna , Kautiainen Hannu , Karppinen Helena , Tilvis Reijo , Strandberg Timo , Pitkälä Kaisu H 
Published: January 2023

Abstract

Background
Symptom burden causes suffering amongst older adults and is associated with healthcare visits and prognosis.

Aims
We evaluated the prevalence of 10 symptoms and changes in symptom burden amongst home-dwelling older adults in 2019 and 2021 using Finnish cohort data. We analysed factors associated with symptom burden increase during follow-up.

Methods
Altogether 1,637 people aged 75+ participated in the Helsinki Ageing Study postal survey in 2019, where they reported the presence of 10 common symptoms over the past 2 weeks. Of them, 785 participated in a follow-up in 2021, where the same symptoms were queried. We compared the prevalence of various symptoms and symptom burden scores in the 2-year interval and evaluated factors associated with increased symptom burden during this time.

Results
Of participants, 33% reported at least one daily symptom in 2019 versus 44% in 2021. Symptom burden increased by a mean ratio of 1.29 between 2019 and 2021. The most common symptoms were joint pain, back pain, urinary incontinence and fatigue. The prevalence of four symptoms increased between 2019 and 2021: joint pain, urinary incontinence, dizziness and shortness of breath. Higher age, reduced functional capacity and comorbidities were associated with higher odds of symptom burden increase during follow-up. Psychological well-being (PWB) was strongly associated with lower odds of symptom burden increase in the logistic regression model.

Conclusions
Symptom burden increased in our cohort aged 75+ between 2019 and 2021 before and during the COVID-19 pandemic. PWB was associated with lower odds of acquiring additional symptoms over time.
High-Intensity Focused Electromagnetic Field With Synchronized Radiofrequency Achieves Superior Gluteal Muscle Contouring Than High-Intensity Focused Electromagnetic Field Procedure Alone
Authors: DiBernardo Barry , Chilukuri Suneel , McCoy J D , Katz Bruce , Goldberg David J 
Published: January 2023

Abstract

Background
The high-intensity focused electromagnetic field (HIFEM) procedure is an effective method for noninvasive toning and shaping of buttocks.

Objectives
To investigate and compare the efficacy of simultaneous application of HIFEM procedure with radiofrequency (RF) heating vs HIFEM standalone procedure on the buttocks.

Methods
Sixty-seven subjects (21-67 years, BMI 16-34 kg/m2) were recruited and divided into two groups. Group A received simultaneous HIFEM + RF therapy, and group B received standalone HIFEM treatments. All participants underwent four 30-minute bilateral treatments on the buttocks. The MRI was used to evaluate the changes in muscle and fat thickness.

Results
Data of 32 subjects from group A and 31 subjects from group B were reviewed at 1-month follow-up. On average, subjects from group A showed a 31.3% higher increase in muscle thickness, as shown in the MRI evaluation. The gluteal muscle thickness continued to grow and peaked at a 3-month follow-up, wherein 27 patients were evaluated in each group (n = 54). Group A showed on average +24.7% increase (gluteus maximus +8.5 ± 1.9 mm, medius +6.0 ± 1.1 mm, minimus +2.9 ± 0.8 mm), while group B exhibited only +15.9% increase in muscle thickness (gluteus maximus +5.2 ± 1.1 mm, medius +3.6 ± 1.0 mm, minimus +1.6 ± 0.4 mm). On average, group A showed a 35.6% higher growth in muscle thickness. Treatments were safe and comfortable with high satisfaction rates. No adverse event was reported throughout the study.

Conclusions
Our results suggest that simultaneous use of HIFEM + RF is safe and significantly more effective for gluteal contouring than the HIFEM procedure alone.

Level of Evidence: 2
MiCellAnnGELo: annotate microscopy time series of complex cell surfaces with 3D virtual reality
Authors: Platt Adam , Lutton E Josiah , Offord Edward , Bretschneider Till 
Published: January 2023

Abstract

Summary
Advances in 3D live cell microscopy are enabling high-resolution capture of previously unobserved processes. Unleashing the power of modern machine learning methods to fully benefit from these technologies is, however, frustrated by the difficulty of manually annotating 3D training data. MiCellAnnGELo virtual reality software offers an immersive environment for viewing and interacting with 4D microscopy data, including efficient tools for annotation. We present tools for labelling cell surfaces with a wide range of applications, including cell motility, endocytosis and transmembrane signalling.

Availability and implementation
MiCellAnnGELo employs the cross-platform (Mac/Unix/Windows) Unity game engine and is available under the MIT licence at https://github.com/CellDynamics/MiCellAnnGELo.git, together with sample data. MiCellAnnGELo can be run in desktop mode on a 2D screen or in 3D using a standard VR headset with a compatible GPU.

Supplementary information
Supplementary data are available at Bioinformatics online.
Sodium-glucose cotransporter-2 inhibitor therapy in kidney transplant patients with type 2 or post-transplant diabetes: an observational multicentre study
Authors: Sánchez Fructuoso Ana I , Bedia Raba Andrea , Banegas Deras Eduardo , Vigara Sánchez Luis A , Valero San Cecilio Rosalía , Franco Esteve Antonio , Cruzado Vega Leonidas , Gavela Martínez Eva , González Garcia María E , Saurdy Coronado Pablo , Morales Nancy D Valencia , Zarraga Larrondo Sofía , Ridao Cano Natalia , Mazuecos Blanca Auxiliadora , Hernández Marrero Domingo , Beneyto Castello Isabel , Paul Ramos Javier , Sierra Ochoa Adriana , Facundo Molas Carmen , González Roncero Francisco , Torres Ramírez Armando , Cigarrán Guldris Secundino , Pérez Flores Isabel 
Published: January 2023

ABSTRACTBackgroundSodium–glucose cotransporter-2 inhibitors (SGLT2is) have cardioprotective and renoprotective effects. However, experience with SGLT2is in diabetic kidney transplant recipients (DKTRs) is limited.MethodsThis observational multicentre study was designed to examine the efficacy and safety of SGLT2is in DKTRs. The primary outcome was adverse effects within 6 months of SGLT2i treatment.ResultsAmong 339 treated DKTRs, adverse effects were recorded in 26%, the most frequent (14%) being urinary tract infection (UTI). In 10%, SGLT2is were suspended mostly because of UTI. Risk factors for developing a UTI were a prior episode of UTI in the 6 months leading up to SGLT2i use {odds ratio [OR] 7.90 [confidence interval (CI) 3.63–17.21]} and female sex [OR 2.46 (CI 1.19–5.03)]. In a post hoc subgroup analysis, the incidence of UTI emerged as similar in DKTRs treated with SGLT2i for 12 months versus non-DKTRs (17.9% versus 16.7%). Between baseline and 6 months, significant reductions were observed in body weight [−2.22 kg (95% CI −2.79 to −1.65)], blood pressure, fasting glycaemia, haemoglobin A1c [−0.36% (95% CI −0.51 to −0.21)], serum uric acid [−0.44 mg/dl (95% CI −0.60 to −0.28)] and urinary protein:creatinine ratio, while serum magnesium [+0.15 mg/dl (95% CI 0.11–0.18)] and haemoglobin levels rose [+0.44 g/dl (95% CI 0.28–0.58]. These outcomes persisted in participants followed over 12 months of treatment.ConclusionsSGLT2is in kidney transplant offer benefits in terms of controlling glycaemia, weight, blood pressure, anaemia, proteinuria and serum uric acid and magnesium. UTI was the most frequent adverse effect. According to our findings, these agents should be prescribed with caution in female DKTRs and those with a history of UTI.
New approaches in developing medicinal herbs databases
Authors: Fathifar Zahra , Kalankesh Leila R , Ostadrahimi Alireza , Ferdousi Reza 
Published: January 2023

Abstract
Medicinal herbs databases have become a crucial part of organizing new scientific literature generated in medicinal herbs field, as well as new drug discoveries in the information era. The aim of this review was to track the current status of medicinal herbs databases. Search for finding medicinal herbs databases was carried out via Google and PubMed. PubMed was searched for papers introducing medicinal herbs databases by the recruited search strategy. Papers with an active database on the web were included in the review. Google was also searched for medicinal herbs databases. Both retrieved papers and databases were reviewed by the authors. In this review, the current status of 25 medicinal herbs databases was reviewed, and the important characteristics of databases were mentioned. The reviewed databases had a great variety in terms of characteristics and functions. Finally, some recommendations for the efficient development of medicinal herbs databases were suggested. Although contemporary medicinal herbs databases represent much useful information, adding some features to these databases could assist them to have better functionality. This work may not cover all the necessary information, but we hope that our review can provide readers with fundamental concepts, perspectives and suggestions for constructing more useful databases.
Non-invasive diagnosis of transthyretin cardiac amyloidosis utilizing typical late gadolinium enhancement pattern on cardiac magnetic resonance and light chains
Authors: Slivnick Jeremy A , Alvi Nazia , Singulane Cristiane C , Scheetz Seth , Goyal Akash , Patel Hena , Sarswat Nitasha , Addetia Karima , Fernandes Fabio , Vieira Marcelo Luiz Campos , Cafezeiro Caio Rebouças Fonseca , Carvalhal Suênia Freitas , Simonetti Orlando P , Singh Jai , Lang Roberto M , Zareba Karolina M , Patel Amit R 
Published: January 2023

Abstract

Aims
While cardiac magnetic resonance (CMR) is often obtained early in the evaluation of suspected cardiac amyloidosis (CA), it currently cannot be utilized to differentiate immunoglobulin (AL) and transthyretin (ATTR) CA. We aimed to determine whether a novel CMR and light-chain biomarker-based algorithm could accurately diagnose ATTR-CA.

Methods and results
Patients with confirmed AL or ATTR-CA with typical late gadolinium enhancement (LGE) and Look-Locker pattern for CA on CMR were retrospectively identified at three academic medical centres. Comprehensive light-chain analysis including free light chains, serum, and urine electrophoresis/immunofixation was performed. The diagnostic accuracy of the typical CMR pattern for CA in combination with negative light chains for the diagnosis of ATTR-CA was determined both in the entire cohort and in the subset of patients with invasive tissue biopsy as the gold standard. A total of 147 patients (age 70 ± 11, 76% male, 51% black) were identified: 89 ATTR-CA and 58 AL-CA. Light-chain biomarkers were abnormal in 81 (55%) patients. Within the entire cohort, the sensitivity and specificity of a typical LGE and Look-Locker CMR pattern and negative light chains for ATTR-CA was 73 and 98%, respectively. Within the subset with biopsy-confirmed subtype, the CMR and light-chain algorithm were 69% sensitive and 98% specific.

Conclusion
The combination of a typical LGE and Look-Locker pattern on CMR with negative light chains is highly specific for ATTR-CA. The successful non-invasive diagnosis of ATTR-CA using CMR has the potential to reduce diagnostic and therapeutic delays and healthcare costs for many patients.