bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modest Molinism
Authors: Bergmann Michael 
Published: May 2023

Molinism, which says that God has middle knowledge, offers one of the most impressive and popular ways of combining libertarian creaturely freedom with full providential control by God. The aim of this paper is to explain, motivate, and defend a heretofore overlooked version of Molinism that I call ‘Modest Molinism’. In Section 1, I explain Modest Molinism and make an initial case for it. Then, in Sections 2 and 3, I defend Modest Molinism against Dean Zimmerman’s anti-Molinist argument, which is directed at all versions of Molinism, including Modest Molinism. Zimmerman’s anti-Molinist argument combines two distinct and separable challenges to Molinism that I call the ‘Irrelevance Objection’ and the ‘Extreme Manipulation Objection’. Despite the fact that Zimmerman intertwines these two objections, they require separate treatment. Thus, Section 2 will raise concerns about Zimmerman’s Irrelevance Objection and Section 3 will focus on concerns about Zimmerman’s Extreme Manipulation Objection.
Control domótico y monitoreo por medio de IOT
Authors: Reina-Cufiño Manuel Ricardo 
Published: May 2023

En este documento se presenta el proceso desarrollado como opción de grado con el diseño e implementación de un prototipo de un sistema de Control Domótico y monitoreo por medio de IoT para personas en condición de discapacidad visual utilizando comandos de voz, en el cual se evidencia el uso de una Intel galileo de segunda generación tarjeta en la cual se realizó la programación correspondiente al control domótico por medio de comandos de voz haciendo uso del IDE de Arduino, junto con una App inventor en la cual se efectúa el reconocimiento de los comandos enviados a la placa de procesamiento de Intel mediante un celular con sistema operativo android, de igual forma se realizó el monitoreo de variables como temperatura y ritmo cardíaco por medio de la plataforma Ubidots de IoT mediante el uso de un Arduino uno, junto con un escudo Ethernet para poder así visualizar dichas variables, al igual que generar un mensaje de alerta a nuestro teléfono móvil informándonos que se ha producido una anomalía en los parámetros preestablecidos con anterioridad en la plataforma, también es necesario mencionar algunas pruebas realizadas frente a algunas de las potencialidades que posee la Intel galileo como una prueba realizada en el software python al comprobar su conectividad y el funcionamiento con los pines de salida de la tarjeta.
The influence of acute dietary nitrate supplementation on skeletal muscle fatigue and recovery in older women
Authors: Zoughaib William S. , Hoffman Richard L. , Yates Brandon A. , Moorthi Ranjani N. , Lim Kenneth , Coggan Andrew R. 
Published: May 2023

AbstractOlder individuals fatigue more rapidly during, and recover more slowly from, dynamic exercise. Women are particularly vulnerable to these deleterious effects of aging, which increases their risk of falling. We have shown that dietary nitrate (NO3−), a source of nitric oxide (NO) via the NO3− → nitrite (NO2−) → NO pathway, enhances muscle speed and power in older individuals in the non‐fatigued state; however, it is unclear if it reduces fatigability and/or improves recoverability in this population. Using a double‐blind, placebo‐controlled, crossover design, we studied 18 older (age 70 ± 4 years) women who were administered an acute dose of beetroot juice (BRJ) containing either 15.6 ± 3.6 or <0.05 mmol of NO3−. Blood samples were drawn throughout each ~3 h visit for plasma NO3− and NO2− analysis. Peak torque was measured during, and periodically for 10 min after, 50 maximal knee extensions performed at 3.14 rad/s on an isokinetic dynamometer. Ingestion of NO3−‐containing BRJ increased plasma NO3− and NO2− concentrations by 21 ± 8 and 4 ± 4 fold, respectively. However, there were no differences in muscle fatigue or recovery. Dietary NO3− increases plasma NO3− and NO2− concentrations but does not reduce fatigability during or enhance recoverability after high intensity exercise in older women.
Cage restriction‐induced physical inactivity promotes subsequent hepatic apoptosis during tail suspension in young male rats
Authors: Dobashi Shohei , Naito Hisashi , Yoshihara Toshinori 
Published: May 2023

AbstractThis study investigated the impact of long‐term physical inactivity on hepatic cytoprotective‐ and inflammatory‐related protein expressions in young rats and the subsequent apoptotic response during microgravity stress simulated by tail suspension. Four‐week‐old male Wistar rats were randomly assigned to the control (CT) and physical inactivity (IN) groups. The floor space of the cages provided to the IN group was reduced to half of that provided to the CT group. After 8 weeks, rats in both groups (n = 6–7) underwent tail suspension. Their livers were harvested immediately before (0 day) or 1, 3, and 7 days after tail suspension. Levels of hepatic heat shock protein 72 (HSP72), an anti‐apoptotic protein, reduced over 7 days of tail suspension in the IN group than in the CT group (p < 0.01). Fragmented nucleosomes in the cytoplasmic fraction of the liver, an apoptotic index, were drastically increased by physical inactivity and tail suspension, and this change was significantly greater after 7 days of tail suspension in the IN group than in the CT group (p < 0.01). The apoptotic response was accompanied by the upregulation of pro‐apoptotic proteins (cleaved caspase‐3 and ‐7). Moreover, the levels of other pro‐apoptotic proteins (tumor necrosis factor‐1α and histone deacetylase 5) were also significantly higher in the IN than in the CT group (p < 0.05). Our results indicated that 8 weeks of physical inactivity decreased hepatic HSP72 levels and promoted hepatic apoptosis during the subsequent 7 days of tail suspension.
Enhancing the efficiency of polytetrafluoroethylene-modified silica hydrosols coated solar panels by using artificial neural network and response surface methodology
Authors: Ramasamy Kirthika , Murugesan Chandrasekar , Thamilkolunthu Senthilkumar 
Published: May 2023

Abstract
In this article, an attempt was made to improve the efficiency of coated solar panels by using artificial neural networks (ANNs) and response surface methodology (RSM). Using the spray coating technique, the glass surface of the photovoltaic solar panel was coated with silicon dioxide nanoparticles incorporated with polytetrafluoroethylene-modified silica sols. Multilayer perceptron with feed-forward back-propagation algorithm was used to develop ANN models for improving the efficiency of the coated solar panels. Out of the 200 sets of data collected, 75% were used for training and 25% were used for testing. On evaluating the models using performance indicators, a four-input technological parameter model (silicon dioxide nanoparticle quantity, coating thickness, surface temperature and solar insolation) with eight neurons in a single hidden layer combination was observed to be the best. The prediction accuracy indicator values of the ANN model were 0.9612 for the coefficient of determination, 0.1971 for the mean absolute percentage error, 0.2317 for the relative root mean square error and 0.00741 for the mean bias error. Using a central composite design model, empirical relationships were developed between input and output responses. The significance of the developed model was ascertained by using analysis of variance, up to a 95% confidence level. For optimization, the RSM was used, and a high efficiency of 17.1% was predicted for the coated solar panel with optimized factors; it was validated to a very high level of predictability. Using interaction and perturbation plots, a ranking of the parameters was done.
Implementing Antitrust Regulations in Dynamic Industries: The Case of the U.S. Cottonseed Industry
Authors: Magnier Alexandre , Kalaitzandonakes Nicholas , Allen Marcus Tim 
Published: May 2023

Abstract
In this paper, we reconsider the rationale used to justify a complaint filed by the U.S. Department of Justice regarding the acquisition of a cottonseed company by an agricultural biotechnology company. With the benefit of hindsight, we show that the competitive assessment overlooked significant market developments that were altering the competitive position of the firms under investigation. This review is intended to raise awareness of the complexities of enforcing antitrust policy in a dynamic environment, with a special emphasis on agricultural markets. We argue that antitrust analysis should incorporate a process view of competition to better account for present market dynamics and the everchanging competitive environment.
Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis
Authors: Yang Gangqi , Li Hongyan , Dong Zheng , Deng Kai , Lu Yinying 
Published: May 2023

Abstract
The chemokine, C-X-C motif chemokine ligand 12 (CXCL12) and its G-protein-coupled receptor (GPCR) and C-X-C chemokine receptor type 4 (CXCR4), are closely associated with promoting hepatocellular carcinoma (HCC) chemotaxis and metastasis. The binding of CXCL12 and CXCR4 depends on the heterotrimeric Gi proteins to regulate actin polymerisation and mobility in HCC. Although the role of GPCR/Gi signalling in carcinogenesis migration has been intensively studied, the detailed mechanism remains largely unknown. In this study, a small interfering RNA technique was used to knock down the Nucleophosmin 1 (NPM1) gene expression. Through the chemotaxis and invasion assays, wound healing, proliferation, filamentous-actin, immunofluorescence, immunohistochemical assays, and co-immunoprecipitation assays, we investigated the specific biological role and underlying mechanisms of the NPM1 in HCC. Additionally, dimethyl fumarate (DMF), a fumaric acid ester, was used to inhibit the HCC cell chemokines and metastasis by regulating ELMO1 and NPM1. Therefore, this study reported that NPM1 gene expression was upregulated in the HCC tissues and cell lines. The NPM1 knockdown significantly inhibited the proliferation, migration, and chemotaxis of the HepG2 cells in vitro. Further mechanistic studies suggested that the NPM1 interacts with ELMO1 and the CXCL12/CXCR4 pathway activates NPM1-dependent regulation of the ELMO1 localisation. Furthermore, the DMF significantly inhibited tumour metastasis induced by the NPM1/ELMO1 signalling pathway, as observed in in vitro cell functional experiments. These data suggested that as a potentially novel therapeutic approach, the simultaneous targeting of NPM1 and ELMO1 could effectively be used to treat HCC.
Selbstfürsorge älterer Menschen durch die Selbstanwendung von Hausmitteln – Eine Analyse im Rahmen der HoPES3-Studie
Authors: Stolz Regina , Klocke Carina , Schalhorn Friederike , Mächler Ruth , Frick Eckhard , Strassner Cornelia , Sturm Noemi , Joos Stefanie , Valentini Jan 
Published: May 2023

Zusammenfassung

Hintergrund: Hausmittel (HM) gelten als Ressource der Selbstfürsorge bei chronischen Erkrankungen. In der BMBF-geförderten, cluster-randomisierten HoPES3-Studie wurde die Nutzung von HM durch ältere Patient/-innen untersucht. Ziel war es, die Aspekte Spiritualität, soziale Aktivität und Selbstfürsorge (durch Beratung zu HM) in der hausärztlichen Versorgung zu stärken.

Fragestellungen: Welche Maßnahmen sind zur Selbstfürsorge älterer Menschen geeignet? Wie hoch ist die Anzahl der HM Nutzer/-innen? Welche HM Arten werden angewendet? Welche Einstellungen und Beweggründe haben ältere Patient/-innen hinsichtlich HM Anwendung?

Methode: Entwicklung von Infozepten (Anleitungen zur Selbstanwendung von Hausmitteln), Fragebogengestützte Erhebung der teilnehmenden Patient/-innen (n= 297). Leitfadengestützte Interviews mit Patient/-innen (n=29).

Ergebnisse: Es wurden 17 Infozepte entwickelt. Zu Studienbeginn nutzten 33 % der Patient/-innen der Interventionsgruppe (IG) und 39 % der Kontrollgruppe (KG) HM. Nach sechs Monaten waren es 47 % (IG) und 35 % (KG). Zentrale Beweggründe scheinen die Stärkung der Selbstwirksamkeit, das Gefühl der Selbstbestimmtheit im Umgang mit der eigenen Gesundheit und die Vermeidung von Medikamenten zu sein.

Diskussion und Schlussfolgerung: Die Ergebnisse können dazu beitragen die Ressource HM besser in die Therapieentscheidung bei älteren Patient/-innen einzubeziehen. Die Beratung zu HM in der hausärztlichen Praxis könnte eine niederschwellige Maßnahme zur gezielten Stärkung der Selbstwirksamkeit und Lebensqualität von älteren Patient/-innen sein.
Preseason Integrative Neuromuscular Training Improves Selected Measures of Physical Fitness in Highly Trained, Youth, Male Soccer Players
Authors: Hammami Raouf , Negra Yassine , Nebigh Amar , Ramirez-Campillo Rodrigo , Moran Jason , Chaabene Helmi 
Published: May 2023

Abstract
Hammami, R, Negra, Y, Nebigh, A, Ramirez-Campillo, R, Moran, J, and Chaabene, H. Preseason integrative neuromuscular training improves selected measures of physical fitness in highly trained, youth, male soccer players. J Strength Cond Res 37(6): e384–e390, 2023—This study examined the effects of an 8-week integrative neuromuscular training (INT) program, including balance, strength, plyometric, and change of direction exercises, on measures of physical fitness in youth male soccer players. Twenty-four male soccer players participated in this study. They were randomly allocated into an INT (n = 12; age = 15.7 ± 0.6 years, body height = 179.75 ± 6.54 cm, body mass = 78.20 ± 7.44 kg, maturity-offset = +2.2 ± 0.6 years) or an active control (CG, n = 12; age = 15.4 ± 0.8 years, body height = 178.4 ± 6.4 cm, body mass = 72 ± 8.3 kg, maturity-offset = +1.9 ± 0.7 years) group. Before and after training, tests to measure dynamic balance (Y-Balance test [YBT]), muscle strength (one repetition maximum [1RM]), muscle power (five jump test [FJT], single-leg hop test [SLHT], and countermovement jump [CMJ] height), linear sprint time (10 and 30-m), and change of direction with ball (CoDball) were performed. The analysis of covariance was used to test between-group differences (INT vs. CG) at posttest using baseline values as covariates. Significant, large, between-group differences at posttest were noted for the YBT (p = 0.016; d = 1.1), 1RM (p = 0.011; d = 1.2), FJT (p = 0.027; d = 1.0), SLHT (p = 0.04; d = 1.4), CMJ height (p < 0.001; d = 1.9), 10-m sprint (p < 0.01; d = 1.6), and CoDball (p < 0.05; d = 0.9) in favor of the INT group. Significant moderate-to-large pre-to-post changes were detected in the INT group for YBT, 1RM, CMJ height, SLHT, FJT, 10-m and 30-m sprint time, and CoDball test (d = 0.7 to 3.07, p < 0.05). No significant pre-to-post changes were observed in the CG (p > 0.05), except for 10-m sprint time (d = 1.3; p < 0.05). Exposure to INT twice weekly is effective and time efficient to improve various measures of physical fitness in highly trained youth male soccer players.
Toward Professionalization of the Strength and Conditioning Field
Authors: Altiner Baykal M. L. , Dixon Marlene A. , Nite Calvin , Stock Matt S. 
Published: May 2023

ABSTRACT
Collectively, strength and conditioning (S&C) as an industry has experienced immense growth since its emergence, both as an occupation and as an applied science. As a result, coaches continue to lend their expertise to new contexts, encourage empirical research, and persistently engage in the processes of professionalization to improve S&C credentialing and expertise. Despite tremendous progress, the authors encourage industry leaders (professional associations and individuals) to reflect on the industry's origins and infrastructure dynamics concerning the accreditation, education, credentials, and overall professional development of S&C practitioners. As a field, S&C is in a prime position to develop and implement an effective regulatory system toward increased professionalism and effective practice. Thus, this article introduces conceptual tools from organizational behavior to better support S&C professionalization efforts. First, the topic of professions and institutional work is introduced and defined. Second, the relationship between professionals (individual and collective) and institutions during professionalization is illustrated. Third, a reflexive overview of research concerning contemporary issues and trends in the field (i.e., field disparity, credentialing, negligence and injury, and social capital) related to professionalism is highlighted. Finally, precise institutional work strategies and their applications are offered to support the industry's maturation as a profession.
Rol de las mujeres en la conservación de la cerámica de Cácota como patrimonio cultural de Norte de Santander Colombia en el marco de la economía naranja.
Authors: Carvajal-Rodríguez Julio César , Núñez-Rodríguez José de Jesús , Carrillo-Guecha Angélica Alexandra 
Published: May 2023

La presente investigación tiene como propósito el proceso de reconstrucción de los saberes ancestrales de la cerámica Cacoteña, resaltando el rol determinante que han desarrollado las mujeres artesanas desde sus orígenes y su papel en el desarrollo y conservación de éste patrimonio cultural, uno de los más importantes en Colombia.
La reconstruir de los saberes cerámicos permitirá a las mujeres artesanas incorporarlas en los procesos de elaboración y producción, a través de las capacitaciones en nuevas técnicas, en donde se integre lo biocultural y pedagógico, logrando de ésta forma la inserción en el marco de las políticas de la economía naranja, lo que haría más relevante el papel de ésta en la dinámica no solo cultural sino económica de la región.
Penilaian Efektivitas Penerapan Sistem Manajemen Kompetensi Laboratorium Uji dan Kalibrasi Sesuai ISO/IEC 17025:2017
Authors: Triharto Masripah , Fadila Mustika , Pramukti Septi Rizkine , Oktari Zaidi 
Published: May 2023

PENILAIAN EFEKTIVITAS PENERAPAN SISTEM MANAJEMEN KOMPETENSI LABORATORIUM UJI DAN KALIBRASI SESUAI ISO/IEC 17025:2017. Pemantauan efektivitas penerapan sistem manajemen Laboratorium Uji dan Kalibrasi PRTBBN sesuai persyaratan ISO/IEC 17025:2017 dilakukan dengan tujuan memastikan semua persyaratan yang dipersyaratkan telah diimplementasikan secara efektif dan untuk dapat mendeteksi masalah yang ada, sehingga PRTBBN dapat melihat peluang perbaikan dan peningkatan untuk memperkuat penerapan sistem manajemen. Penelitian ini menggunakan data ketidaksesuaian pada survailen KAN Tahun 2021. Fokus penelitian ini adalah pada ketidaksesuaian yang terkait dengan kualitas output yaitu ketidaksesuaian berpotensi pada penurunan keabsahan hasil uji / kalibrasi, yaitu pada klausul 7.7 yaitu terdapat ketidaksesuaian peralatan yang belum melakukan kegiatan uji banding / uji profisiensi sesuai dengan waktu yang telah dijadwalkan. PRTBBN telah melakukan implementasi pemastian keabsahan hasil uji, diantaranya adalah penggunaan bahan referensi atau bahan standar, penggunaan peralatan yang telah terkalibrasi, penggunaan quality control, pengujian dengan metode uji yang telah divalidasi atau di verifikasi, dll. Dengan banyaknya upaya lain dalam pemastian hasil uii dan kalibrasi yang tidak menjadi ketidaksesuaian merupakan indikator masih efektifnya implementasi sistem manajemen laboratorium uji dan kalibrasi di PRTBBN, serta tidak adanya ketidaksesuaian kategori 1 mengindikasi tidak adanya kegagalan dalam mengimplementasikan satu atau lebih persyaratan akreditasi yang berakibat timbulnya keraguan terhadap kredibilitas hasil penilaian kesesuaian yang diterbitkan lembaga penilaian kesesuaian. Untuk mencegah tidak terulangnya ketidaksesuaian tersebut maka PRTBBN harus menyiapkan sumber daya baik personil maupun pendanaan dalam perencanaan kegiatan uji banding/uji profisiensi.
Impact of Innovation in the Food and Beverage Industry: Challenges and Opportunities
Authors: Punj Divya 
Published: May 2023

It is a well-known fact that the tourism business, which covers many sectors like housing, catering, transport, visitor attractions, entertainment, etc., may significantly contribute to the growth of the economy of any nation. Operations for serving food and beverages are advancing in both development and quality while also improving. Because most tourists spend money on food and beverages, the travel and hospitality sector depends on providing services of high quality. People today prefer novel food and beverage service methods that are also entertaining, alluring, and presentable. The physical environment, which includes the service staff, ambiance, table settings, and lighting, is also crucial in attracting visitors. A key factor in keeping customers happy and encouraging them to return to the restaurant is service quality. Numerous trends affect the sector of food and drinks, and these trends can make or break a restaurant business. The research topic focuses on recent advancements in the provision of food and beverage practices and the significance of the physical environment for any restaurateur.
A Robust Netrosophic Clustering Based Raven Routing Optimization to Alleviate Void Hole and Energy Depletion in IoT WSN
Authors: Singh Kamred Udham 
Published: May 2023

Wireless Sensor Networks (WSNs) find extensive utilisation in diverse domains, including but not limited to environmental monitoring, industrial control, and healthcare. Wireless Sensor Networks (WSNs) have a crucial function in gathering and relaying information from sensor nodes to a central node or sink in various applications. Wireless Sensor Networks (WSNs) encounter various obstacles that can have a significant impact on their performance and lifespan. These challenges include but are not limited to limited battery life, void holes, and energy depletion.
Several routing algorithms have been suggested in scholarly works to tackle these concerns, such as clustering-based routing, data-centric routing, and location-based routing. Nonetheless, a majority of these algorithms possess constraints and may not be appropriate for every situation.
The present study introduces a methodology called Rncrro (Robust Netrosophic Clustering Based Raven Routing Optimisation) that aims to mitigate the issues of void holes and energy depletion in Wireless Sensor Networks (WSNs). The proposed approach utilises Netrosophic Clustering and Raven Optimisation algorithms in tandem to enhance the efficacy and resilience of the routing mechanism.
The significance of this study is rooted in its capacity to surmount the constraints of current routing algorithms and furnish a superior and dependable resolution for Wireless Sensor Networks (WSNs). The proposed methodology has the potential to enhance the performance and longevity of Wireless Sensor Networks (WSNs) by mitigating void holes and energy depletion. This, in turn, can result in more efficient and dependable data collection and transmission across diverse applications.