bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting potential small molecule–miRNA associations utilizing truncated schatten p-norm
Authors: Wang Shudong , Liu Tiyao , Ren Chuanru , Wu Wenhao , Zhao Zhiyuan , Pang Shanchen , Zhang Yuanyuan 
Published: June 2023

Abstract
MicroRNAs (miRNAs) have significant implications in diverse human diseases and have proven to be effectively targeted by small molecules (SMs) for therapeutic interventions. However, current SM–miRNA association prediction models do not adequately capture SM/miRNA similarity. Matrix completion is an effective method for association prediction, but existing models use nuclear norm instead of rank function, which has some drawbacks. Therefore, we proposed a new approach for predicting SM–miRNA associations by utilizing the truncated schatten p-norm (TSPN). First, the SM/miRNA similarity was preprocessed by incorporating the Gaussian interaction profile kernel similarity method. This identified more SM/miRNA similarities and significantly improved the SM–miRNA prediction accuracy. Next, we constructed a heterogeneous SM–miRNA network by combining biological information from three matrices and represented the network with its adjacency matrix. Finally, we constructed the prediction model by minimizing the truncated schatten p-norm of this adjacency matrix and we developed an efficient iterative algorithmic framework to solve the model. In this framework, we also used a weighted singular value shrinkage algorithm to avoid the problem of excessive singular value shrinkage. The truncated schatten p-norm approximates the rank function more closely than the nuclear norm, so the predictions are more accurate. We performed four different cross-validation experiments on two separate datasets, and TSPN outperformed various most advanced methods. In addition, public literature confirms a large number of predictive associations of TSPN in four case studies. Therefore, TSPN is a reliable model for SM–miRNA association prediction.
Fracture risks and their mechanisms in atopic dermatitis, focusing on receptor activator of nuclear factor kappa-B ligand
Authors: Sakai Takashi 
Published: June 2023

Abstract
Recent multiple studies have shown that the long-term consequences of atopic dermatitis (AD) include an increased risk of osteoporosis and fracture, especially an increase in hip, pelvic, spinal and wrist fractures. AD is very common worldwide, and some kinds of fractures, such as hip fractures, are associated with increased mortality, which has a substantial socioeconomic impact; however, the precise mechanisms for this remain unclear. Receptor activator of nuclear factor kappa-Β (RANK) ligand (RANKL) and osteoprotegerin (OPG) are members of the tumour necrosis factor ligand and receptor family, members of which also are known as bone biomarkers. Alterations in the RANKL/RANK/OPG system and the balance among these factors (represented by the RANKL/OPG ratio) are central to the pathogenesis of bone loss from osteoporosis, and it is postulated that there is a potential association between the serum levels of RANKL and OPG, and bone density or fracture. Recently, our research group demonstrated that the serum RANKL/OPG ratio positively correlated with AD severity and suggests fracture risk in older women with AD. This review summarizes and discusses the risk and mechanisms of osteoporotic fracture in AD. RANKL may be involved in the pathogenesis of AD, regarding not only bone abnormality but also inflammation. Although further investigation will be needed to verify the hypotheses, recent findings may provide new insights into the pathogenesis of AD and therapeutic targets.
Metal deposits associated with brain atrophy in the deep gray matter nucleus in Wilson’s disease
Authors: Huang Zihuan , Yang Jie , Chen Dingbang , Zhou Xiangxue , Xiao Xia , Wang Junqiao , Wang Mengzhu , Zhao Jing , Chu Jianping 
Published: June 2023

Abstract
Regional atrophy and metal deposition are typical manifestations in Wilson’s disease, but their relationship has not been systematically investigated. We aim to investigate the association of regional brain atrophy and metal deposition in the deep gray matter nucleus at MRI in Wilson’s disease. We acquired the structural and susceptibility mapping and performed a cross-sectional comparison of volume and susceptibility in deep gray matter nucleus. The most extensive and severe atrophy was detected in brain regions in neuro-Wilson’s disease, as well as the most widespread and heaviest metal deposits. Metal deposits were significantly negatively correlated with volume in the bilateral thalamus, caudate, and putamen. None of correlation was found between the clinical score with volume or susceptibility in the focused regions. In the 1-year follow-up analysis, the volume of right thalamus, globus pallidus, and brainstem and the susceptibility of the left caudate have decreased significantly as the symptom improvement. In Wilson’s disease, phenotypes have varied scope and extend of volumetric atrophy and metal deposits. This study is expected to take the lead in revealing that in neuro-Wilson’s disease, greater regional atrophy associated with heavier metal deposits in Wilson’s disease. Moreover, after 1-year treatment, the imaging data have changed as the patient’s condition improvement.
Using occipital ⍺-bursts to modulate behavior in real-time
Authors: Vigué-Guix Irene , Soto-Faraco Salvador 
Published: June 2023

Abstract
Pre-stimulus endogenous neural activity can influence the processing of upcoming sensory input and subsequent behavioral reactions. Despite it is known that spontaneous oscillatory activity mostly appears in stochastic bursts, typical approaches based on trial averaging fail to capture this. We aimed at relating spontaneous oscillatory bursts in the alpha band (8–13 Hz) to visual detection behavior, via an electroencephalography-based brain-computer interface (BCI) that allowed for burst-triggered stimulus presentation in real-time. According to alpha theories, we hypothesized that visual targets presented during alpha-bursts should lead to slower responses and higher miss rates, whereas targets presented in the absence of bursts (low alpha activity) should lead to faster responses and higher false alarm rates. Our findings support the role of bursts of alpha oscillations in visual perception and exemplify how real-time BCI systems can be used as a test bench for brain-behavioral theories.
Disentangling the connection between Marx’s ‘sixth’ countertendency to a falling rate of profit and the rise of financialisation
Authors: Di Bucchianico Stefano , Salvati Luigi 
Published: June 2023

Abstract
Marxian economics has been dealing extensively with the issue of falling profitability and its connection with financialisation. One finds in this line of research contributions linking financialisation with the list of counter-elements to the Law of the Tendency of the Rate of Profit to Fall, with financialisation being interpreted as the ‘sixth’. In the past, various authors have either briefly commented on the ‘sixth’ factor or left it aside. We aim to provide an alternative interpretation, based on three elements. First, the role of joint-stock companies’ issuance of long-term financing instruments yielding low remuneration. Second, the fact that sectors such as railways and public utilities, belonging to the category of natural monopolies, are excluded from gravitation towards an average rate of profit. Third, the role of the organic composition of capital in determining differences in sectoral profitability. Therefore, we claim that the sixth element should be read as a reference to natural monopolies remaining outside the field of profit rate equalisation.
On the policy relevance of agricultural economics
Authors: Just David R 
Published: June 2023

Abstract
The past decade has seen the transition of agricultural economics from perceived irrelevance to being seen as key to saving the world from an array of grand challenges. These challenges include global climate change, non-communicable diseases, hunger and poverty. These challenges require international cooperation. Such cooperation is undermined by global conflicts in which agricultural trade is disrupted either to incentivise policy change or through conflict. The world is vulnerable if trade can be exploited for political power or disrupted by other actions taken for political power. Agricultural economists are uniquely situated to address these issues.
Are high-severity burns in Alpine beech forests related to eruptive fire behavior?
Authors: Conedera Marco , Pezzatti Gianni Boris , Guglielmetti Andrea , Maringer Janet , Gehring Eric , Krebs Patrik 
Published: June 2023

Abstract
In the complex Alpine topography, canyon-like terrain morphology combined with steep slopes may cause sudden changes in fire behavior, for instance, turning fast-spreading surface fires into eruptive fires. This phenomenon was observed during the vegetation dormancy in mountain beech (Fagus sylvatica L.) stands, a forest type usually spared from wildfires. The aim of this study is to understand the impact of eruptive fire behavior on the post-fire trajectories of beech trees. To this end, over the course of 3 years, we monitored the post-fire dynamics of 100 beech trees subjected to different fire intensities in February 2020, including a small-scale eruptive fire behavior associated with a steep slope (~41.4° on average) and canyon-like terrain features. Dendrometric and sylvicultural parameters and fire-related damages such as the presence of bark blackening, scars, foliage loss, crashes of branches or whole trees, and parasitic attacks were assessed. The observed medium to high fire severity was highly dependent on the position of the tree within the eruptive fire sector, whereas the relationship with dendrometric and sylvicultural tree characteristics, such as the crown position or the stem diameter, was less clear. Due to the lethal temperatures generated by the heat convection within the eruptive fire sector, the exposed bud and cambium tissues of the beech trees partially or totally failed to develop in the first post-fire season. Beech crown and stem tissue killed by exposure to convective heat fluxes rapidly dries out, loses its elasticity, and becomes brittle. Starting from the second post-fire season, this greatly increases the risk of the crashing of these crown parts and/or entire trees. A detailed understanding of the factors leading to an eruptive fire behavior would highly benefit the fire risk assessment and the detailed planning of the firefighting tactics in mountain areas, eventually increasing the safety of firefighters and preventing post-fire natural hazards, such as rockfall, erosion, surface runoff, and debris flow.
The art collections and museum of King William II of the Netherlands (1792–1849)
Authors: Bergvelt Ellinoor 
Published: June 2023

Abstract
King William II of the Netherlands (1792–1849) created important art collections with the benefit of advice from leading dealers at home and abroad, for which special premises were built in one of the royal palaces in The Hague. Whenever the monarch was not in residence, these were made accessible to visitors. Following William’s sudden death in 1849 almost everything was sold and the paintings are now distributed around the world. An attempt is made here to reconstruct the contemporary presentation of these collections, both in The Hague and before that in the palace in Brussels; online appendices present, respectively, an account of the images of the collection in the Kneuterdijk Palace, The Hague (1842–1850); a chronological list of the acquisitions of William as prince and king in 1817–28 and 1837–48; and details of eleven paintings now in the Wallace Collection.
Contralateral breast cancer risk in patients with breast cancer and a germline-BRCA1/2 pathogenic variant undergoing radiation
Authors: van Barele Mark , Akdeniz Delal , Heemskerk-Gerritsen Bernadette A M ,   Genepso, Andrieu Nadine , Noguès Catherine ,   HEBON, van Asperen Christi J , Wevers Marijke , Ausems Margreet G E M , de Bock Geertruida H , Dommering Charlotte J , Gómez-García Encarnacion B , van Leeuwen Flora E , Mooij Thea M ,   EMBRACE, Easton Douglas F , Antoniou Antonis C , Evans D Gareth , Izatt Louise , Tischkowitz Marc , Frost Debra , Brewer Carole , Olah Edit , Simard Jacques , Singer Christian F , Thomassen Mads , Kast Karin , Rhiem Kerstin , Engel Christoph , de la Hoya Miguel , Foretová Lenka , Jakubowska Anna , Jager Agnes , Sattler Margriet G A , Schmidt Marjanka K , Hooning Maartje J 
Published: June 2023

Abstract

Background
Radiation-induced secondary breast cancer (BC) may be a concern after radiation therapy (RT) for primary breast cancer (PBC), especially in young patients with germline (g)BRCA–associated BC who already have high contralateral BC (CBC) risk and potentially increased genetic susceptibility to radiation. We sought to investigate whether adjuvant RT for PBC increases the risk of CBC in patients with gBRCA1/2-associated BC.

Methods
The gBRCA1/2 pathogenic variant carriers diagnosed with PBC were selected from the prospective International BRCA1/2 Carrier Cohort Study. We used multivariable Cox proportional hazards models to investigate the association between RT (yes vs no) and CBC risk. We further stratified for BRCA status and age at PBC diagnosis (&lt;40 and &gt;40 years). Statistical significance tests were 2-sided.

Results
Of 3602 eligible patients, 2297 (64%) received adjuvant RT. Median follow-up was 9.6 years. The RT group had more patients with stage III PBC than the non-RT group (15% vs 3%, P &lt; .001), received chemotherapy more often (81% vs 70%, P &lt; .001), and received endocrine therapy more often (50% vs 35%, P &lt; .001). The RT group had an increased CBC risk compared with the non-RT group (adjusted hazard ratio [HR] = 1.44; 95% confidence interval [CI] = 1.12 to 1.86). Statistical significance was observed in gBRCA2 (HR = 1.77; 95% CI = 1.13 to 2.77) but not in gBRCA1 pathogenic variant carriers (HR = 1.29; 95% CI = 0.93 to 1.77; P = .39 for interaction). In the combined gBRCA1/2 group, patients irradiated when they were younger than or older than 40 years of age at PBC diagnosis showed similar risks (HR = 1.38; 95% CI = 0.93 to 2.04 and HR = 1.56; 95% CI = 1.11 to 2.19, respectively).

Conclusions
RT regimens minimizing contralateral breast dose should be considered in gBRCA1/2 pathogenic variant carriers.
Parents’ Preferences for Primary Care-Based Behavioral Services and the COVID-19 Pandemic: A Mixed Method Study
Authors: Hails Katherine A , Wellen Brianna C , Simoni Marisa , Gaultney Wendy M , Petts Rachel A , Hostutler Cody A , Riley Andrew R 
Published: June 2023

Abstract

Objective
This study examined how family factors impacted parents’ attitudes toward integrated behavioral health (IBH) in pediatric primary care during the COVID-19 pandemic. We hypothesized that COVID-19 impact would predict family functioning challenges, and that pre-existing familial contextual factors would predict parents’ interest in IBH modalities.

Methods
Parents of children ages 1.5–5 years (N = 301) from five primary care clinics completed a survey with measures assessing familial contextual factors (income, race and ethnicity, and parents’ childhood adversity), COVID-19 impact on family relationships and wellbeing, family functioning (child behavior, parenting self-efficacy, and parent psychological functioning), and parents’ preferences for behavioral support in primary care. A subsample of parents (n = 23) completed qualitative interviews to provide deeper insights into quantitative relationships.

Results
Higher COVID-19 impact was significantly associated with worse parent mental health and child behavior problems, as well as lower interest in IBH virtual support options. Overall, lower SES and racial and/or ethnic minority parents both indicated greater interest in IBH modalities compared to higher SES and White parents, respectively. Qualitative interviews identified how pandemic stressors led to increases in parents’ desire for behavioral support from pediatricians, with parents sharing perspectives on the nature of support they desired, including proactive communication from providers and variety and flexibility in the behavioral supports offered.

Conclusions
Findings have important implications for the provision of behavioral supports for families in primary care, underlying the need to increase parents’ access to IBH services by proactively providing evidence-based resources and continuing to offer telehealth support.
The extensin protein SAE1 plays a role in leaf senescence and is targeted by the ubiquitin ligase SINA4 in tomato
Authors: Lu Han , Niu Xiangli , Fan Youhong , Yuan Yulin , Huang Li , Zhao Bingyu , Liu Yongsheng , Xiao Fangming 
Published: June 2023

Abstract
Extensins are hydroxyproline-rich glycoproteins and generally play a structural role in cell wall integrity. In this study, we determined a novel role of tomato (Solanum lycopersicum) SENESCENCE-ASSOCIATED EXTENSIN1 (SAE1) in leaf senescence. Both gain- and loss-of-function analyses suggest that SAE1 plays a positive role in leaf senescence in tomato. Transgenic plants overexpressing SAE1 (SAE1-OX) exhibited premature leaf senescence and enhanced dark-induced senescence, whereas SAE1 knockout (SAE1-KO) plants displayed delayed development-dependent and dark-induced leaf senescence. Heterologous overexpression of SlSAE1 in Arabidopsis also led to premature leaf senescence and enhanced dark-induced senescence. In addition, the SAE1 protein was found to interact with the tomato ubiquitin ligase SlSINA4, and SlSINA4 promoted SAE1 degradation in a ligase-dependent manner when co-expressed in Nicotiana benthamiana leaves, suggesting that SlSINA4 controls SAE1 protein levels via the ubiquitin–proteasome pathway. Introduction of an SlSINA4-overexpression construct into the SAE1-OX tomato plants consistently completely eliminated accumulation of the SAE1 protein and suppressed the phenotypes conferred by overexpression of SAE1. Taken together, our results suggest that the tomato extensin SAE1 plays a positive role in leaf senescence and is regulated by the ubiquitin ligase SINA4.
A JWST/NIRCam study of key contributors to reionization: the star-forming and ionizing properties of UV-faint z ∼ 7−8 galaxies
Authors: Endsley Ryan , Stark Daniel P , Whitler Lily , Topping Michael W , Chen Zuyi , Plat Adèle , Chisholm John , Charlot Stéphane 
Published: June 2023

ABSTRACT
Spitzer/Infrared Array Camera (IRAC) imaging has revealed that the brightest z ∼ 7−8 galaxies often exhibit young ages and strong nebular line emission, hinting at high ionizing efficiency among early galaxies. However, IRAC’s limited sensitivity has long hindered efforts to study the fainter, more numerous population often thought largely responsible for reionization. Here, we use Cosmic Evolution Early Release Science (CEERS) JWST/NIRCam data to characterize 116 ultraviolet (UV)-faint (median MUV = −19.5) z ∼ 6.5−8 galaxies. The spectral energy distributions are typically dominated by young (∼10–50 Myr), low-mass (M* ∼ 108 M⊙) stellar populations, and we find no need for extremely high stellar masses (∼1011 M⊙). Considering previous studies of UV-bright (MUV ∼ −22) z ∼ 7−8 galaxies, we find evidence for a strong (5–10 times) increase in specific star formation rate (sSFR) toward lower luminosities (median sSFR = 103 Gyr−1 in CEERS). The larger sSFRs imply a more dominant contribution from OB stars in the relatively numerous UV-faint population, perhaps suggesting that these galaxies are very efficient ionizing agents (median ξion = 1025.7 erg−1 Hz). In spite of the much larger sSFRs, we find little increase in [O iii] + H  β equivalent widths towards fainter MUV (median ≈780 $\mathrm{\mathring{A}}$). If confirmed, this may indicate that a substantial fraction of our CEERS galaxies possess extremely low metallicities (≲3 per cent Z⊙) where [O iii] emission is suppressed. Alternatively, high ionizing photon escape fractions or bursty star formation histories can also weaken the nebular lines in a subset of our sample. While the majority of galaxies in our sample are very blue (median β = −2.0), we identify a significant tail of very dusty galaxies (β ∼ −1) at ≈0.5$L_\mathrm{UV}^\ast$ which may contribute significantly to the z ∼ 7−8 star formation rate density.
Changes in Social Network Structure in Response to Exposure to Formal Credit Markets
Authors: Banerjee Abhijit , Breza Emily , Chandrasekhar Arun G , Duflo Esther , Jackson Matthew O , Kinnan Cynthia 
Published: June 2023

Abstract
We show that the entry of formal financial institutions can have far-reaching and long-lasting impacts on informal lending and social networks more generally. We first study the introduction of microfinance in 75 villages in Karnataka, India, 43 of which were exposed to microfinance. Using difference-in-differences, we show that networks shrank more in exposed villages. Moreover, links between households that were both unlikely to borrow from microfinance were at least as likely to disappear as links involving likely borrowers. We replicate these surprising findings in the context of a randomised controlled trial (RCT) in Hyderabad, where a microfinance institution randomly selected 52 of 104 neighbourhoods to enter first. Four years after all neighbourhoods were treated, households in early-entry neighbourhoods had credit access longer and had larger loans. We again find fewer social relationships between households in these neighbourhoods, even among those ex-ante unlikely to borrow. Because the results suggest global spillovers, atypical in usual models of network formation, we develop a new dynamic model of network formation that emphasizes chance meetings, where efforts to socialize generate a global network-level externality. Finally, we analyse informal borrowing and the sensitivity of consumption to income fluctuations. Households unlikely to take up microcredit suffer the greatest loss of informal borrowing and risk sharing, underscoring the global nature of the externality.
“You Have to Be Careful About Every Detail” How the COVID-19 Pandemic Shaped the Experiences of Canadian Personal Support Workers Working in Home Care
Authors: Nizzer Sonia , Ruco Arlinda , Moreira Nicole A. , Holness D. Linn , Nichol Kathryn A. , King Emily C. , McKay Sandra M. 
Published: June 2023

Objectives
Personal support workers (PSWs) are an essential but vulnerable workforce supporting the home care sector in Canada. Given the impact COVID-19 has had on healthcare workers globally, understanding how PSWs have been impacted is vital.

Methods
We conducted a qualitative descriptive study to understand the working experiences of PSWs over the COVID-19 pandemic. Nineteen semistructured interviews were conducted, and analysis was guided by the collaborative DEPICT framework.

Results
Personal support workers are motivated by an intrinsic duty to work and their longstanding client relationships despite feeling vulnerable to transmission and infection. They experienced co-occurring occupational stressors and worsening work conditions, which impacted their overall well-being.

Conclusions
Pandemic conditions have contributed to increased occupational stress among PSWs. Employers must implement proactive strategies that promote and protect the well-being of their workforce while advocating for sector improvements.