bluuebunny/crossref_metadata_2025_split huggingface dataset:
A narrative review of psychiatric features of traumatic encephalopathy syndrome as conceptualized in the 20th century
Authors: Iverson Grant L. , Kissinger-Knox Alicia , Huebschmann Nathan A. , Castellani Rudolph J. , Gardner Andrew J. 
Published: July 2023

IntroductionSome ultra-high exposure boxers from the 20th century suffered from neurological problems characterized by slurred speech, personality changes (e.g., childishness or aggressiveness), and frank gait and coordination problems, with some noted to have progressive Parkinsonian-like signs. Varying degrees of cognitive impairment were also described, with some experiencing moderate to severe dementia. The onset of the neurological problems often began while they were young men and still actively fighting. More recently, traumatic encephalopathy syndrome (TES) has been proposed to be present in athletes who have a history of contact (e.g., soccer) and collision sport participation (e.g., American-style football). The characterization of TES has incorporated a much broader description than the neurological problems described in boxers from the 20th century. Some have considered TES to include depression, suicidality, anxiety, and substance abuse.PurposeWe carefully re-examined the published clinical literature of boxing cases from the 20th century to determine whether there is evidence to support conceptualizing psychiatric problems as being diagnostic clinical features of TES.MethodsWe reviewed clinical descriptions from 155 current and former boxers described in 21 articles published between 1928 and 1999.ResultsMore than one third of cases (34.8%) had a psychiatric, neuropsychiatric, or neurobehavioral problem described in their case histories. However, only 6.5% of the cases were described as primarily psychiatric or neuropsychiatric in nature. The percentages documented as having specific psychiatric problems were as follows: depression = 11.0%, suicidality = 0.6%, anxiety = 3.9%, anger control problems = 20.0%, paranoia/suspiciousness = 11.6%, and personality change = 25.2%.DiscussionWe conclude that depression, suicidality (i.e., suicidal ideation, intent, or planning), and anxiety were not considered to be clinical features of TES during the 20th century. The present review supports the decision of the consensus group to remove mood and anxiety disorders, and suicidality, from the new 2021 consensus core diagnostic criteria for TES. More research is needed to determine if anger dyscontrol is a core feature of TES with a clear clinicopathological association. The present findings, combined with a recently published large clinicopathological association study, suggest that mood and anxiety disorders are not characteristic of TES and they are not associated with chronic traumatic encephalopathy neuropathologic change.
Convolutional neural network based on photoplethysmography signals for sleep apnea syndrome detection
Authors: Jiang Xinge , Ren YongLian , Wu Hua , Li Yanxiu , Liu Feifei 
Published: July 2023

IntroductionThe current method of monitoring sleep disorders is complex, time-consuming, and uncomfortable, although it can provide scientifc guidance to ensure worldwide sleep quality. This study aims to seek a comfortable and convenient method for identifying sleep apnea syndrome.MethodsIn this work, a one-dimensional convolutional neural network model was established. To classify this condition, the model was trained with the photoplethysmographic (PPG) signals of 20 healthy people and 39 sleep apnea syndrome (SAS) patients, and the influence of noise on the model was tested by anti-interference experiments.Results and DiscussionThe results showed that the accuracy of the model for SAS classifcation exceeds 90%, and it has some antiinterference ability. This paper provides a SAS detection method based on PPG signals, which is helpful for portable wearable detection.
A randomized clinical trial to evaluate the efficacy of L-carnitine L-tartrate to modulate the effects of SARS-CoV-2 infection
Authors: Badaro Roberto , Barbosa Josiane Dantas Viana , de Araujo Neto Cesar Augusto , Machado Bruna Aparecida Souza , Soares Milena Botelho Pereira , de Senna Valter , Taddeo Marcelo , de Araújo Lila Teixeira , Durkee Shane , Donninger Raymond , Judge Kevin , Saiyed Zainulabedin 
Published: July 2023

IntroductionL-carnitine (LC) has been associated with inflammatory mediator reduction and with downregulating the angiotensin-converting enzyme-2 (ACE2) receptor, which is the target of SARS-CoV-2 attachment.MethodsThis pilot phase 2 randomized, double-blind placebo-controlled trial contained two cohorts. Cohort 1 comprised 101 individuals with negative RT-PCR SARS-CoV-2 test results who cohabitated with an individual diagnosed with SARS-CoV-2 infection. Cohort 2 comprised 122 individuals with positive SARS-CoV-2 RT-PCR test results who were asymptomatic or had mild COVID-19 pneumonia symptoms. Participants in each cohort were randomized 1:1 to receive either 2 g elemental oral LC supplementation or placebo daily for 21 days. Primary endpoints included adverse events, SARS-CoV-2 infection incidence in Cohort 1, and disease progressions in Cohort 2. Secondary endpoints included between-group laboratory profile comparisons and Cohort 2 ACE1/ACE2 plasma levels. Disease progression was compared between the Cohort 2 groups using chest computed tomography.ResultsIn Cohort 1, two SARS-CoV-2 infections occurred in each group. The common adverse events included headache, dyspnea, and tiredness. In Cohort 2, platelet counts were elevated, and fibrinogen levels reduced in the LC group compared with those of the placebo group.ConclusionOur study showed that LC was well-tolerated and suggests it modulates coagulation pathways. Furthermore, chest computed tomography images of the Cohort 2 LC group showed significant lung lesion improvement, suggesting that LC may slow COVID-19 progression.
Understanding the link between gut microbiota, dietary intake, and nutritional status in children with autism and typical development
Authors: Mendive Dubourdieu Paula , Guerendiain Marcela 
Published: July 2023

BackgroundGut microbiota plays a potential role in human health and different disorders such as autism spectrum disorder (ASD). Therefore, we analyzed gut bacteria composition in children with ASD and typical development (TD), and its relationship with nutritional status and dietary intake.MethodsA descriptive cross-sectional study was carried out in 3- to 12-year-old children (ASD = 30, TD = 28). Dietary intake (applying food frequency questionnaires) and body mass index-for-age (expressed in z-score) were determined. Children were divided into normal weight and excess weight (risk of overweight + overweight + obesity), and the ASD group was categorized into gluten- and casein-free diet (ASD-diet) or no diet (ASD-no diet). The relative abundance of gut bacteria was analyzed in fecal samples by 16S rRNA sequencing.ResultsChildren with excess weight had lower Roseburia than normal weight. Fewer Bifidobacterium longum and higher Clostridium glycolicum were found in the ASD group compared with TD one. Participants with excess weight and ASD had lower Roseburia and Faecalibacterium prausnitzii and higher Eubacterium ventricosum and Flavonifractor plautii than the TD group with the same nutritional status. Positive and negative associations were found between the bacteria genus and species, and the intake of dairy, vegetable drinks, cereals with and without gluten, food source of proteins, fish, food source of fat, and coconut oil, in unadjusted models and after adjustment for age, diet/no diet, ASD/TD.ConclusionSignificant differences in microbial community composition were found between children with ASD and TD, considering their nutritional status and dietary intake.
Deep learning-enhanced radiomics for histologic classification and grade stratification of stage IA lung adenocarcinoma: a multicenter study
Authors: Pei Guotian , Wang Dawei , Sun Kunkun , Yang Yingshun , Tang Wen , Sun Yanfeng , Yin Siyuan , Liu Qiang , Wang Shuai , Huang Yuqing 
Published: July 2023

BackgroundPreoperative prediction models for histologic subtype and grade of stage IA lung adenocarcinoma (LUAD) according to the update of the WHO Classification of Tumors of the Lung in 2021 and the 2020 new grade system are yet to be explored. We aim to develop the noninvasive pathology and grade evaluation approach for patients with stage IA LUAD via CT-based radiomics approach and evaluate their performance in clinical practice.MethodsChest CT scans were retrospectively collected from patients who were diagnosed with stage IA LUAD and underwent complete resection at two hospitals. A deep learning segmentation algorithm was first applied to assist lesion delineation. Expansion strategies such as bounding-box annotations were further applied. Radiomics features were then extracted and selected followed by radiomics modeling based on four classic machine learning algorithms for histologic subtype classification and grade stratification. The area under the receiver operating characteristic curve (AUC) was used to evaluate model performance.ResultsThe study included 294 and 145 patients with stage IA LUAD from two hospitals for radiomics analysis, respectively. For classification of four histological subtypes, multilayer perceptron (MLP) algorithm presented no annotation strategy preference and achieved the average AUC of 0.855, 0.922, and 0.720 on internal, independent, and external test sets with 1-pixel expansion annotation. Bounding-box annotation strategy also enabled MLP an acceptable and stable accuracy among test sets. Meanwhile, logistic regression was selected for grade stratification and achieved the average AUC of 0.928, 0.837, and 0.748 on internal, independent, and external test sets with optimal annotation strategies.ConclusionsDL-enhanced radiomics models had great potential to predict the fine histological subtypes and grades of early-stage LUADs based on CT images, which might serve as a promising noninvasive approach for the diagnosis and management of early LUADs.
Effects of electroacupuncture on pediatric chronic urinary retention: a case-series study
Authors: Yang Min , Gao Shuai , Yao Hao , He Xin , Fang Jiufei , Chen Yu , Liu Zhishun 
Published: July 2023

ObjectivesThis study aims to preliminarily evaluate the effect and safety of electroacupuncture (EA) in treating pediatric chronic urinary retention (CUR) following lumbosacral surgeries, with treatment duration evaluated.MethodsThis prospective case-series study was performed from August 5, 2017, to July 31, 2022. Pediatric patients diagnosed with CUR following lumbosacral surgeries were included and treated by EA for 2–16 weeks. Responders were defined as participants achieving a reduction of 50% or more in post void residuals (PVR) from baseline. Time-to-event analysis was applied to explore the association between EA treatment duration and response rate. Adverse event was recorded.ResultsTotally 14 participants (mean [SD] age, 12 [4] years) completed EA treatment. Response rate was 71% (10/14) at the 12th week. 50% (7/14) of participants removed catheters at the 12th week, and none of them experienced re-catheterization in the 24-week follow-up. No serious adverse event was reported. Time-to-event analysis estimated that over 50% patients could respond to EA of more than 8 weeks. Subgroup analysis showed that participants with baseline PVR ≥300 ml and CUR duration ≥12 months experienced longer EA duration to reach the response rate of 50%, compared with those whose PVR &lt;300 ml and CUR duration &lt;12 months (median value: 12 weeks vs. 8 weeks, 12 weeks vs. 4 weeks, respectively).ConclusionsEA could reduce PVR for pediatric patients suffering from CUR following lumbosacral surgeries, with long-term efficacy and safety. EA treatment of more than 8 weeks was reasonable. Further study of a larger sample and controlling is needed.Clinical Trial Registrationwww.chictr.org.cn, identifier, ChiCTR1800020222.
A qualitative study into the personal factors influencing secondary school teachers’ motivating styles
Authors: Liu Woon Chia , Kong Leng Chee , Wang Chee Keng John , Kee Ying Hwa , Ng Betsy , Lam Karen , Reeve Johnmarshall 
Published: July 2023

BackgroundAll teachers aspire to create the most motivating classroom climate for their students. This is because students who are motivated demonstrate superior learning outcomes relative to students who are not motivated. According to the Self-Determination Theory (SDT), when teachers establish an autonomy-supportive climate in their classrooms, their students can benefit in numerous developmentally and educationally important ways. Whilst most teachers have an understanding that autonomy-supportive teaching can benefit their students, many of them are unwilling or unable to carry out autonomy-supportive strategies. This can be explained by the implicit and explicit forces (e.g., teaching philosophies and beliefs, personal experiences) imposed on them by their internal (namely, intrapsychic) and external (namely, social) environments. This paper focuses on the personal factors that influence teachers’ adoption and employment of autonomy-supportive instructional behaviours.MethodFollowing a 10-week intervention program on implementing six autonomy-supportive instructional behaviours, we interviewed 59 teachers from 17 secondary schools in Singapore on their adoption and employment of the teaching strategies. Their number of years of teaching experience ranged from 1 to 31 years with a mean of 10.8 years of teaching experience, and 62.71% of them were female.FindingFrom the interviews, we identified several teacher-related personal factors which we labelled “teaching philosophies and beliefs,” “personal experiences,” “motivation to teach,” “personality,” “teachers’ mental and emotional states” and “teaching efficacy.” Through identifying the personal factors, we hope to raise awareness amongst the teachers on the inner forces that can foster or frustrate their own expression of autonomy-supportive instructional behaviours. Given the many plausible benefits that can be derived from autonomy-supportive teaching, we hope that the information gained from this qualitative study can path the way for greater willingness and effort in implementing autonomy-supportive teaching in the classrooms.
Symptoms of anxiety and depression associated with steroid efficacy and clinical outcomes in patients with inflammatory bowel disease
Authors: Duan Shihao , Yang Yi , Cao Yubin , Chen Pingrun , Liang Chang , Zhang Yan 
Published: July 2023

BackgroundAnxiety and depression symptoms are very common in patients with inflammatory bowel disease (IBD). We aimed to explore the impact of anxiety and depression on the efficacy of medications, as well as IBD-related poor outcomes.MethodThis was a prospective longitudinal observational study. Hospital Anxiety and Depression Scale was used to assess anxiety and depression symptoms. Logistic regression analyses were used to assess the association between anxiety/depression and the response to different medications. Kaplan–Meier survival analysis and Cox regression model were applied to analyze the relationship between anxiety/depression and IBD-related poor outcomes, which were defined as urgent IBD-related hospitalization, IBD-related surgery, or death.ResultsA total of 325 IBD patients were enrolled, 118 of whom were treated with corticosteroids, 88 with azathioprine/6-mercaptopurine (AZA/6-MP), and 147 with anti-TNF agents. Anxiety/depression symptoms were found to be significantly related to steroid resistance, but independent of AZA/6-MP and anti-TNF agents nonresponse. There was a significant association between anxiety/depression symptoms and IBD-related poor outcomes. Coexisting with anxiety/depression symptoms was an independent influencing factor of steroid resistance and IBD-related poor outcomes.ConclusionIBD patients with anxiety/depression symptoms were at a higher risk of developing steroid resistance and IBD-related poor outcomes. Future studies are needed to explore whether interventions for anxiety and depression will improve their response to medications and change their prognosis.
Koinfeksi bakteri pada pasien COVID – 19 di ICU
Authors: Gunardi Wani Devita , Widelia Grace Raveena , Pasaribu Donna Mesina 
Published: July 2023

Pada pandemi influenza sebelumnya, koinfeksi bakteri merupakan penyebab kematian terbanyak. Pada pandemi COVID - 19, koinfeksi bakteri juga menyebabkan tingginya angka kematian pada pasien COVID - 19 di ICU. Literatur Riview ini dilakukan untuk mengetahui bakteri penyebab koinfeksi pada pasien COVID - 19 di ICU. Dalam penulisan ini dilakukan pencarian pada database Pubmed dan 7 jurnal dipilih untuk dikaji. Dari hasil analisa jurnal – jurnal tersebut, bakteri yang paling banyak teridentifikasi menyebabkan koinfeksi pada pasien COVID - 19 di ICU adalah Stenotrophomonas maltophilia (33,8%), diikuti dengan Acinetobacter baumannii (22,65%), Pseudomonas aeruginosa (22,44%) dan Staphylococcus aureus (16,77%). Penemuan bakteri – bakteri ini berhubungan dengan lama perawatan di ICU, penggunaan ventilator mekanik serta pemberian antibiotic sebelum masuk ICU.
Hubungan Indeks Massa Tubuh dengan Kejadian Kanker Prostat dan Gleason Score di Rumah Sakit Siloam Kupang
Authors: Homalessy Valerio Christopher , Shintia Christina  , Sumbayak Erma Mexcorry 
Published: July 2023

Kanker prostat dapat disebut sebagai kanker yang umum didiagnosis pada pria. Risiko kanker prostat meningkat seiring bertambahnya usia. Tujuan penelitian ini untuk mengetahui apakah adanya hubungan antara Indeks Massa Tubuh (IMT) dengan kanker prostat dan gleason score di Rumah Sakit Siloam Kupang. Metode penelitian kualitatif dengan desain cross sectional dan menggunakan data sekunder rekam medik dengan teknik consecutive sampling. Hasil penelitian, Pasien dengan diagnosa kanker prostat di Rumah Sakit Siloam Kupang periode 2017-2021 sebanyak 80 kasus dan bukan kanker prostat sebanyak 60 kasus. Indeks Massa Tubuh pada kelompok pasien kanker prostat terbanyak pada non obesitas sebanyak 54 orang (67,5%) dan pada bukan kanker prostat sebanyak 34 orang (56,67%). Kasus kanker prostat terbanyak dengan derajat histopatologi High Gleason Score sebanyak 45 kasus (56,25%), dan derajat histopatologi Low Grade Score sebanyak 35 kasus (43,75). Berdasarkan hasil analisis dengan chi square, diketahui bahwa tidak ada hubungan antara Indeks Massa Tubuh dengan Kejadian Kanker Prostat memiliki nilai p = 0,189 (p > 0,05) dan dengan Gleason Score memiliki nilai p = 0,764 (p > 0,05) Simpulan, Tidak terdapat hubungan antara Indeks Massa Tubuh dengan kejadian kanker prostat dan gleason score di Rumah Sakit Siloam Kupang.
Athripsodes saral sp. n., a new Leptoceridae (Trichoptera) from the Kurdistan Province, Iran
Authors: Ibrahimi Halil , Mohammadi Habibollah , Ghaderi Edris , Karimian Erfan , Mansouri Arman , Molodi Farshad 
Published: July 2023

In this paper, we describe Athripsodes saral sp. n., a new species from the Kurdistan Province, Iran, which belongs to the A. sewangensis Species Group. The new species is morphologically most similar to Athripsodes caglari Sipahiler, 2008 from Turkey and Athripsodes sewangensis Martynov, 1925 from Armenia. However, it can be distinguished from all known species of this group by notable morphological characteristics of the male and female genitalia. In males, the dorsal projection of the coxopodite is slightly longer or equal in size to the harpago, while in females, the dorsolateral lobes of segment IX exhibit a distinct triangular shape, visible in both ventral and dorsal views. Furthermore, the new species displays distinct characteristics from its closest congeners in the shape of segment IX, prolongations of segment X, and the structure of the aedeagus in males.
Athripsodes saral sp. n. is the third known species of the genus Athripsodes Billberg, 1820 known from Iran.
« Et l’Afrique, sait-elle un chant sur moi ? » identités du lieu & lieux de l’identité dans La ferme africaine de Karen Blixen
Authors: Heide Marina 
Published: July 2023

Il s’agit d’étudier le rapport complexe qu’établit l’écrivain danoise Karen Blixen entre les notions de lieu et d’identité dans son roman autobiographique, La ferme africaine (1937). La géographie tient naturellement une place de choix dans cette œuvre vouée à chanter l’Afrique – terre d’exil, terre promise et paradis perdu. Le lien avec l’auteur, qui s’épanouit dans ce paysage africain, est fusionnel mais pas univoque. À des identités multiples correspondent de nombreuses géographies, réelles comme imaginaires. Cet article met en jeu des notions centrales comme la définition de soi par l’autre, l’idée d’un ailleurs, le credo moderne et la question coloniale.
miR-155-5p PROMOTES CD34+ APOPTOSIS AND INHIBITS BONE MARROW HEMATOPOIESIS IN MYELODYSPLASTIC SYNDROMES BY RAC1/CREB/MIR-15B AXIS
Authors: Cao Meiwan , Peng BaoLing , Xu WanFu , Chen PeiYu , Chen Huan , Ye LiPing , Xie Jing , Wang HongLi , Ren Lu , Xiong LiYa , Zhu JingNan , Xu XiangYe , Geng LanLan , Gong SiTang 
Published: July 2023

Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid clonal diseases that are characterized by ineffective bone marrow hematopoiesis. Since studies have confirmed the significance of miRNAs in ineffective hematopoiesis in MDS, the current report elucidated the mechanism mediated by miR-155-5p. The bone marrow of MDS patients was collected to detect miR-155-5p and to analyze the correlation between miR-155-5p and clinicopathological variables. Isolated bone marrow CD34+ cells were transfected with lentiviral plasmids that interfere with miR-155-5p, followed by apoptosis analysis. Finally, miR-155-5p-targeted regulation of RAC1 expression was identified, as well as the interaction between RAC1 and CREB, the co-localization of RAC1 and CREB, and the binding of CREB to miR-15b. As measured, miR-155-5p was upregulated in the bone marrow of MDS patients. Further cell experiments validated that miR-155-5p promoted CD34+ cell apoptosis. miR-155-5p could reduce the transcriptional activity of miR-15b by inhibiting RAC1, dissociating the interaction between RAC1 and CREB, and inhibiting the activation of CREB. Upregulating RAC1, CREB, or miR-15b could reduce miR-155-5p-mediated apoptosis promotion on CD34+ cells. Additionally, miR-155-5p could force PD-L1 expression, and this effect was impaired by elevating RAC1, CREB, or miR-15b. In conclusion, miR-155-5p mediates PD-L1-mediated apoptosis of CD34+ cells in MDS by RAC1/CREB/miR-15b axis, thereby inhibiting bone marrow hematopoiesis.