bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of bulbospongiosus muscle injection with botulinum-A toxin for treatment of primary premature ejaculation. A preliminary results of randomized controlled trial
Authors: Ghaith Ahmed , Almekaty Khaled , Ragab Maged , Rashed Ayman , Hagras Ayman , Ghoneem Ayman , Raheem Amr Abdel , Zahran Mohamed 
Published: July 2023

Abstract
Background:
Premature ejaculation is a common sexual disorder that significantly impacts the quality of life for both men and their partners. Various treatment options have been explored, including behavioral techniques, selective serotonin reuptake inhibitors (SSRIs), and local anesthetics. However, the outcomes of these treatments have been inconsistent for many patients.
This study aimed to evaluate the effectiveness and safety of injecting botulinum-A toxin into the bulbospongiosus muscle for treating premature ejaculation (PPE) in Egyptian patients.
Materials and methods:
Sixty patients with PPE were randomly assigned prospectively to two groups: one receiving botulinum-A toxin injections and the other receiving saline injections as a placebo. The injection was done under US guidance to localize the site of bulbospongiosus muscle.
Results:
After the follow-up period, 57 patients completed the study. Initially, there were no significant differences between the two groups in terms of age, baseline Intravaginal Ejaculation Latency Time (IELT), Premature Ejaculation Profile (PEP) score, or partner satisfaction.
Throughout the study, there were no statistically significant differences between the two groups in terms of IELT, PEP score, or female partner satisfaction at 1, 3, and 6 months after the intervention. However, the treatment group did show a significant increase in the median PEP score at 1 and 3 months compared to baseline. Unfortunately, no significant change was observed at 6 months, and there was no improvement in IELT or female partner satisfaction at any of the time points.
Conclusion:
While the treatment was found to be safe, this study did not demonstrate significant efficacy of botulinum-A toxin injections into the bulbospongiosus muscle for managing PPE symptoms when compared to a placebo. Further research with larger sample sizes is needed to validate these findings and explore alternative treatment options for PPE.
Energy performance of compressed biogas production from co-digestion of Salix and dairy manure: factoring differences between Salix varieties
Authors: Kalita Saurav , Potter Hanna Karlsson , Nordberg Åke , Sandgren Mats , Hansson Per-Anders 
Published: July 2023

Abstract
Biogas from anaerobic digestion is a versatile energy carrier that can be upgraded to compressed biogas (CBG) as a renewable and sustainable alternative to natural gas. Organic residues and energy crops are predicted to be major sources of bioenergy production in the future. Pre-treatment can reduce the recalcitrance of lignocellulosic energy crops such as Salix to anaerobic digestion, making it a potential biogas feedstock. This lignocellulosic material can be co-digested with animal manure, which has the complementary effect of increasing volumetric biogas yield. Salix varieties exhibit variations in yield, composition and biomethane potential values, which can have a significant effect on the overall biogas production system. This study assessed the impact of Salix varietal differences on the overall mass and energy balance of a co-digestion system using steam pre-treated Salix biomass and dairy manure (DaM) to produce CBG as the final product. Six commercial Salix varieties cultivated under unfertilised and fertilised conditions were compared. Energy and mass flows along this total process chain, comprising Salix cultivation, steam pre-treatment, biogas production and biogas upgrading to CBG, were evaluated. Two scenarios were considered: a base scenario without heat recovery and a scenario with heat recovery. The results showed that Salix variety had a significant effect on energy output-input ratio (R), with R values in the base scenario of 1.57–1.88 and in the heat recovery scenario of 2.36–2.94. In both scenarios, unfertilised var. Tordis was the best energy performer, while the fertilised var. Jorr was the worst. Based on this energy performance, Salix could be a feasible feedstock for co-digestion with DaM, although its R value was at the lower end of the range reported previously for energy crops.
Analysis of Controlled Diode Bridge Clamped based 3L-VSI using Space Vector approach
Authors: Sonar Santosh , Mondal Sanjoy 
Published: July 2023

Abstract
In this paper, some important aspects related to operating modes, dead time in inverter switches, merits, demerits and PWM technique implementation of controlled diode bridge clamped based 3L-VSI is discussed in detail. A high-frequency PWM technique based on the principle of space vector concept is used for the analysis of switching states. Two main type of switching techniques based on space vector approach namely, continuous and discontinuous PWM techniques have been used. For the discontinuous PWM sequence, the main focus here is to accurately select the switching sequence for the first switching cycle so that nearest three-level switching can be achieved without any extra switching instant over a fundamental cycle of the output voltage. Dependence of modulation index on switching states selection has been pointed out. To verify the correctness of the proposed approach, simulation and experimental results are presented.
Reproductive strategies, free-swimming tadpoles, and natural history of the Santa Marta rocket frog “Colostethus” ruthveni Kaplan, 1997 (Anura: Dendrobatidae), with a review of the distribution of larval and reproductive characters in Dendrobatoidea
Authors: Polo-Córdoba Fredy , Linares-Vargas Katherin , Montes-Correa Andrés Camilo , Jiménez-Bolaño Juan David , Saboyá-Acosta Liliana , Granda-Rodríguez Hernán 
Published: July 2023

Abstract

Herein, we research several aspects of biology of the Santa Marta rocket frog “Colostethus”ruthvenifrom the Sierra Nevada de Santa Marta, Colombian Caribbean. Quantification of relative abundance and habitat use was provided. Likewise, free-swimming tadpoles and reproductive strategies were described. In addition, the distribution of larval and reproductive characters across Dendrobatoidea were examined as an approach for their evolution and to identify whether these can complement the diagnosis of the “C.”ruthvenigroup. We recorded 853 specimens of “C.”ruthveniin six localities, resulting in a fairly high relative abundance at each site. Leaf-litter and rocks were the most used substrata, although their proportion of uses varying across the sites. The external morphology of free-swimming tadpoles of “C.”ruthveniresembles the former members of theColostethussensu lato. The courtship is a complex interaction of acoustic, visual, and tactile displays, which leads to the cephalic amplexus. "Colostethus"ruthvenishowed wide variation in oviposition sites, including natural and artificial substrates at ground level, as well as creeping vegetation above the ground or water. Therefore, we consider that the species exhibits multiple reproductive modes, one of them previously unknown for anurans. Several larval and reproductive characters of “C.”ruthveniconsist of a compendium of ancestral states. However, some characters are of special interest because these could be considered reversions to ancestral states or apomorphies, which could constitute synapomorphies of the “C.”ruthvenigroup if demonstrated to occur in the other undescribed members of the complex. In addition, we evidenced that "C."ruthveniis the only Dendrobatine with considerably narrow A2-gap. All this information on morphology and natural history provides insight into the evolutionary processes of poison frogs and provides basic information necessary for the management of this potentially endangered species.
Non-ECG-triggered dual-source CTA in children with CHD
Authors: Zhang Shipeng , Zhu Dalin , Mao Baohong , Xie Yijing 
Published: July 2023

Abstract
Objective: To explore the value of non-electrocardiogram-triggered(non-ECG-triggered) on third-generation dual-source CT application in children with congenital heart disease (CHD) in a high heart rate.
Methods:Data on children with CHD received cardiac CT angiography (CTA) were collected between November 2019 and March 2021. CT images were obtained using two different protocols: non-ECG-triggeredand retrospectively-ECG-triggered (retro-ECG-triggered). All children received transthoracic echocardiography (TTE) before surgery . Sex, age, weight, heart rate, volume CT dose index (CTDI vol), and dose length product (DLP) were recorded, and the effective dose (ED) was calculated. Image quality was rated using five-point Likert scales and the diagnostic values of CTA and TTE were compared.
Results:Children’s age ranged from 1 day to 34 months, with minimum and maximum heart rates of 90 bpm and 160 bpm. There were significant differences between the retro- and non-ECG-triggered groups in the average tube current (54.95±23.52 vs. 45.47±24.65 mAs, p=0.003), CTDI vol (2.41±1.6 vs. 0.58±0.27 mGy, p<0.001), DLP (44.43±34.65 vs. 9.92±5.48 mGy.cm, p<0.001), and ED (1.48±0.90 vs. 0.35±0.17 mSv, p<0.001). There was no difference between the two protocols in the demonstration of extracardiac and intracardiac malformations (all p≥0.05). The diagnostic accuracy of both retro- and non- ECG triggering in intracardiac and extracardiac malformations were high with no significant differences (p=1.00, 0.80). The diagnostic advantage of TTE is mainly in intracardiac malformations (p=0.03, 0.01).
Conclusions: High-pitch non-ECG-triggered CTA cansignificantly reduce radiation dose,whereas there was no significant difference in image quality and diagnostic accuracy between non- and retro-ECG-triggered CTA.
Non-Target Screening of Surface Water Samples to Identify Exposome-Related Pollutants: A Case Study from Luxembourg
Authors: Aurich Dagny , Diderich Philippe , Helmus Rick , Schymanski Emma L. 
Published: July 2023

Abstract
Background
Non-target screening of surface water samples collected over an extended period can reveal interesting temporal patterns in exposome-related pollutants. Additionally, geographical data on pollution sources close to the sampling sites, chemical classification data and the consideration of flow paths can provide valuable information on the origins and potential threat of tentatively identified chemical compounds. In this study, 271 surface water samples from 20 sampling sites across Luxembourg were analysed using high resolution mass spectrometry, complementing routine target monitoring efforts in 2019–2022. Data analysis was performed using the open source R-package patRoon, which offers a customizable non-target workflow. By employing open source workflows featuring scoring terms, like spectral match and applying identification levels, tentative identifications can be prioritized, e.g. based on spectral similarity. Furthermore, by utilizing supplementary database information such as PubChemLite annotation categories and classification software such as classyFire, an overall assessment of the potential threats posed by the tentatively identified chemicals was conducted, enabling the prioritization of chemicals for future confirmation through targeted approaches.
Results
The study tentatively identified 375 compounds associated with the exposome including benzenoids, organoheterocyclic compounds, and organic phosphoric acids and derivatives (12 classyFire superclasses, 50 sub-classes). The classification analysis not only revealed temporal variations in agrochemicals, with the majority of identifications occurring in May to July, but also highlighted the prevalence of pharmaceuticals such as venlafaxine in surface waters. Furthermore, potential sources of pollutants, like metallurgic industry or household products were explored by considering common uses and geographical information, as commercial uses of almost 100% of the identified chemicals are known. 41 chemicals were suggested for potential inclusion to governmental monitoring lists for further investigation.
Conclusions
The findings of this study complement existing knowledge on the pollution status of surface water in Luxembourg and highlight the usefulness of non-target screening for identifying temporal and spatial trends in pollutant levels. This approach, performed in a complementary manner to routine monitoring, can help to tentatively identify chemicals of concern for potential inclusion in target monitoring methods following additional confirmation and quantification efforts.
One-step Bio-guided Isolation of Secondary Metabolites from the
Endophytic Fungus Penicillium crustosum Using High-resolution
Semi-preparative HPLC
Authors: Alfattani Abdulelah , Queiroz Emerson Ferreira , Marcourt Laurence , Leoni Sara , Stien Didier , Hofstetter Valerie , Gindro Katia , Perron Karl , Wolfender Jean-Luc 
Published: July 2023

Background:
An endophytic fungal strain Penicillium crustosum was isolated from the
seagrass Posidonia oceanica and investigated to identify its antimicrobial constituents and characterize
its metabolome composition. The ethyl acetate extract of this fungus exhibited antimicrobial
activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as an anti-quorum
sensing effect against Pseudomonas aeruginosa.

Methods:
The crude extract was profiled by UHPLC-HRMS/MS, and the dereplication was assisted
by feature-based molecular networking. As a result, more than twenty compounds were annotated in
this fungus. To rapidly identify the active compounds, the enriched extract was fractionated by semipreparative
HPLC-UV applying a chromatographic gradient transfer and dry load sample introduction
to maximise resolution. The collected fractions were profiled by 1H-NMR and UHPLC-HRMS.

Results:
The use of molecular networking-assisted UHPLC-HRMS/MS dereplication allowed preliminary
identification of over 20 compounds present in the ethyl acetate extract of P. crustosum. The chromatographic
approach significantly accelerated the isolation of the majority of compounds present in the active
extract. The one-step fractionation allowed the isolation and identification of eight compounds (1-8).

Conclusion:
This study led to the unambiguous identification of eight known secondary metabolites
as well as the determination of their antibacterial properties.
Diphenyl Ethers: Isolation, Bioactivities and Biosynthesis
Authors: Liu Bing , Wang Yuxin , Chen Ning , Li Chenxue , Zhao Jintong , Li Ting 
Published: July 2023

Abstract:
Diphenyl ethers (DPEs) are mainly produced by microorganisms and plants. The chemical
structure of DPEs is relatively simple, and all of these compounds have the structure of biphenyl
ethers in their chemical structure, the difference being the difference in the substituents on the benzene
ring. Several recent studies have shown antibacterial, antioxidant, antitumor, antitumor, antihemolytic,
neuroprotective, and anti-Alzheimer effects. DPEs could be candidate compounds for the
treatment of Alzheimer's disease, by inhibiting the aggregation of Aβ42. Many DPEs from natural
products exhibit good biological activity and they play an important role in the control of microbial
infections. Diphenyl ethers have a wide range of applications and research value in the fields of pesticides,
pharmaceuticals, textiles, household products, and public health. In this paper, we review the
research progress of diphenyl ethers isolated from marine and plant endophytic sources in recent
years, including their biosynthesis, and lay the foundation for further utilization and development.
PERKEMBANGAN OTAK PADA ANAK USIA DINI:KAJIAN DASAR NEUROLOGI DAN ISLAM
Authors: Jannah Miftahul 
Published: July 2023

Otak adalah organ utama manusia untuk menjaga kesimbangan fisik dan psikis manusia mulai dari tahapan perkembangan dalam kandungan, bayi, kanak-kanak, remaja sampai usia dewasa dan lansia. Otak menuntun manusia untuk berperilaku positif dan negatif. Otak akan berfungsi positif dalam suasana lingkungan yang positif dan sebaliknya akan berkembang negatif dalam lingkungan yang negatif. Berat otak bayi yang baru lahir 370 g, kemudian pada usia tiga tahun berat otak anak menjadi sekitar seperempat sampai sepertiga dari berat otak orang dewasa, sekitar 1.400 sampai 1.500 g. Perkembangan otak ini dikenal dengan usia “Golden Age”. Setiap orangtua atau significant others yang membesarkan anak harus memahami bahwa pada anak usia dini otak akan berkembang pesat dan sel-sel sel saraf akan berfungsi kuat dan pesat jika diberikan stimulus respon yang tepat. Maknanya anak akan sangat cepat memahami dan cepat meniru dan menghafal apa yang didengar, dilihat, dan diamatinya. Bagi setiap orang yang membesarkan anak, seorang pendidik, baby sitter pun harus mengerti dan memahami bahwa otak adalah organ tubuh manusia yang harus dilindungi dan dijaga agar tidak terkena benda benda keras dan tajam dan tidak terjadi benturan berat dan luka yang dalam yang menjadikan kerusakan pada tumbuh kembang otak. Kajian ini untuk menjadi referensi awal untuk mengetahui bagian bagian otak untuk mengetahui bahwa otak memiliki bagian-bagian yang memiliki fungsinya masing-masing sesuai dengan hasil kajian ilmiah para ahli saraf.
Auditor Materiality Threshold and Audit Quality—Evidence from the Revised ISA 700 in the United Kingdom
Authors: Goh Beng Wee , Lee Jimmy , Li Dan , Li Na , Wang Muzhi 
Published: July 2023

SYNOPSIS
Using a broad sample of U.K. firms that are required to disclose auditor materiality thresholds under the International Standards on Auditing (United Kingdom and Ireland) 700, we examine whether the auditor materiality threshold is associated with audit quality. We document that a lower materiality threshold is associated with higher audit quality, as measured by lower absolute discretionary accruals, higher accruals quality, and a lower propensity to just meet or beat analysts’ earnings expectations. We also find some evidence that the negative association between the materiality threshold and audit quality is attenuated when the audit committee is more effective and when the auditor is more economically dependent on the client, and the negative association is more pronounced when management has a stronger incentive to manage earnings. Overall, our study extends the limited studies on large-sample archival evidence on the implications of audit materiality thresholds on audit outcomes.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: M40; M41; M42.
KAJIAN ARSITEKTUR HIBRID TRADISIONAL DAN FUTURISTIK PADA GEDUNG REKTORAT UNIVERSITAS TANJUNG PURA
Authors: Naufalamas Rafi , Prayogi Lutfi 
Published: July 2023

Ide Arsitektur kontemporer terlahir pada era pasca modern sekitar tahun 1940 yang menjadi konsep dasar dari sebuah karya arsitektur. ilmu arsitektur kontemporer memiliki tiga cabang yang terdiri dari arsitektur logis, arsitektur hibrid, dan arsitektur metafora. Arsitektur hibrid sendiri memliki makna pencampuran antar dua konsep yang berbeda atau berlawanan kutub yang menghasilkan sebuah konsep yang baru. Arsitektur hibrid memiliki metode yang berbeda diantara nya persilangan, pencampuran dan penggabungan. Penelitian ini bertujuan untuk mengetahui metode arsitektur hibrid dengan konsep tradisional dan futuristik pada bangunan pendidikan. Metode yang digunakan adalah kualitatif deskriptif, yaitu dengan mengamati fenomena secara lebih rinci tentang suatu keadaan. Penelitian ini akan menganalisis metode aritektur hibrid pada studi kasus gedug rektorat tanjung pura. Ditemukan bahwa pada kasus Gedung rektorat Tanjung pura menerapkan metode arsitektur hibrid pencampuran pada eksterior yang merupakanarsitektur hibrid percampuran sedangkan pada interior menerapkan arsitektur hibrid persilangan.
Decisiones curriculares preactivas e interactivas de una profesora de Educación
Authors: Caballero Guichard Tamara Paola 
Published: July 2023

La toma de decisiones curriculares de los docentes puede generar una mayor pertinencia del currículum oficial, pues dichas actuaciones posicionan a los docentes como intermediarios entre el currículum como plan y el currículum como vivido. La investigación que se presenta aquí, de corte cualitativo, tuvo como objetivo analizar la toma de decisiones curriculares preactivas e interactivas de una profesora de educación básica en Santiago de Chile. Para la recolección de datos se desarrollaron entrevistas, observación de clase, y se consideraron las planificaciones de clases y bitácoras de la docente. Los resultados mostraron que mientras las decisiones preactivas de la profesora fueron predominantemente reproductivas, en la fase interactiva la profesora desarrolló un ejercicio decisional más autónomo, centrado en la situación de su clase. A su vez, los hallazgos permitieron comprender que su toma de decisiones curriculares se relaciona con múltiples elementos y dimensiones de su práctica, tanto internos como externos.

Basic Education teacher preactive and interactive curriculum decisions
Abstract
Teachers curriculum decisions can generate a greater relevance of the official curriculum, since these actions give teachers a position as intermediaries between the curriculum as a plan and the curriculum as lived. This qualitative research aimed to analyze the preactive and interactive curriculum decisions of a basic education teacher in Santiago de Chile. For data collection, interviews, class observation, and class plans and teacher's logs were considered. The results showed that while the teacher's preactive decisions were predominantly reproductive, in the interactive phase the teacher developed a more autonomous decisional exercise focused on the situation of her class. In turn, the findings allowed us to understand that their curriculum decision-making is related to multiple elements and dimensions of teachers practice, both internal and external.
Características de "buenos docentes" según ingresantes al Profesorado en Matemática de la UNR: un estudio durante dos décadas
Authors: Sgreccia Natalia Fátima , Cirelli Mariela Beatriz , Vital María Beatriz 
Published: July 2023

Desde 2002, el primer día de clase del Profesorado en Matemática de la Universidad Nacional de Rosario (Argentina) se solicita a los ingresantes que identifiquen a sus dos mejores profesores del nivel escolar previo (nivel secundario) y que señalen, para cada uno de ellos, tres características por las cuales les resultan memorables. Dichas características han sido agrupadas según cinco dimensiones de análisis, relativas a la motivación de los estudiantes, la preparación de las clases, la gestión de las clases, el trato con los estudiantes y las formas de evaluar. Se comparten en el presente trabajo los resultados obtenidos de la sistematización de las respuestas a lo largo de dos décadas, con el objetivo de posibilitar la reflexión sobre las cualidades que se relacionan con las buenas prácticas docentes.

Characteristics of “good teachers” according to beginners of the Mathematics Teacher Training of the UNR: a study of over two decades
Abstract
Since 2002, on the first day of class of the Mathematics Teacher Training of the National University of Rosario (Argentina), beginners are asked to identify their two best teachers of the previous school level (secondary level) and to indicate, for each of them, three characteristics for which they are memorable. These characteristics have been grouped according to five dimensions of analysis, relating to student motivation, class preparation, class management, dealing with students and ways of evaluating. The obtained results from the systematization of the answers over two decades are shared in this paper with the aim of enabling reflection on the qualities that are related to good teaching practices.