bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical value of biochemical markers and <sup>68</sup>Ga-DOTATATE PET/CT in the follow-up of patients with pancreatic neuroendocrine tumors: a retrospective study
Authors: Nosov N. A. , Popov S. A. , Rozengauz E. V. , Stanzhevskii A. A. , Granov D. A. , Maystrenko D. N. 
Published: January 2023

INTRODUCTION: Follow-up of patients with pancreatic neuroendocrine tumors (p-NETs) remains little studied and relevant. The role of tumor markers as indicators of recurrence, as well as the relationship between the prevalence of the disease in 68Ga-DOTATATE PET/CT and levels of tumor markers, has been studied in a few publications.OBJECTIVE: To determine the significance of markers and visualization methods in the follow-up of patients with p-NETs.MATERIALS AND METHODS: 68Ga-DOTATATE PET/CT was performed in 73 patients diagnosed with pancreatic NET: 57 patients (78%) were previously treated, 16 patients (22%) underwent primary staging. The levels of serotonin and chromogranin-A (CgA) were studied at the time of PET/CT and at the onset of the disease. CT and MRI were performed within 2 months before PET/CT. Statistics: Spearman’s coefficient was used for correlations. To determine the levels of markers at which it is recommended to enroll 68Ga-DOTATATE PET/CT, a ROC-analysis was performed. The result of the ROC-analysis is presented with a 95% confidence interval.RESULTS: CT and MRI revealed metastases in 45 patients (61.6%), PET/CT revealed foci in 56 patients (76.7%), of which 13 patients had metastases of other anatomical locations, which were not previously detected. Sensitivity of 68Ga-DOTATATE PET/CT to pancreatic NET is 94.8%, specificity is 93.3%. In ROC-analysis, the area under the curve was 0.8 for serotonin (CI95% 0.676–0.924), for CgA 0.81 (CI95% 0.695–0.925). A weak relationship was revealed between the degree of oncomarkers increase and the number of foci: for serotonin r=0.32 (p<0.05), for CgA r=0.298 (p<0.05). No correlation was found between the number of foci and the tumor proliferative activity index (Ki67). Also, for all foci localizations, there was no dependence of SUV max on the levels of markers and Ki67.DISCUSSION: In our study, 68Ga-DOTATATE PET/CT revealed more metastases than routine methods, due to this, the treatment plan and the volume of surgical interventions were adjusted. An increase in the levels of tumor markers highly likely indicates a relapse of the disease. However, the low Spearman correlation coefficient between the number of foci and the levels of serotonin and CgA does not allow us to assume the prevalence of the tumor process by the degree of this rise. In addition, no significant relationship was found between the prevalence of the tumor and the levels of the studied tumor markers.CONCLUSION: 68Ga-DOTATATE PET/CT has higher accuracy in the diagnosis of p-NETs than routine imaging methods. In combination with the determination of the tumor markers levels, the probability of detecting tumor foci increases.
Predictors of radiation-induced skin reactions in patients with T-cell skin lymphomas after total skin irradiation: retrospective cohort study
Authors: Vinogradova Yu. N. , Zaslavskiy D. V. , Zelianina M. I. , Ilyin N. V. 
Published: January 2023

INTRODUCTION: Skin reactions negatively affect a patient’s quality of life and may require radiation therapy premature interruption, what impairs illness control. Numerous agents determine tissue radiosensitivity, but demographic and lifestyle factors remain poorly understood. Those kind of patients herapeutic algorithm demands studies.OBJECTIVE: Radiation-induced skin reactions (RISR) formation and severity prognostic factors determination for primary malignant skin lymphomas patients.MATERIALS AND METHODS: 45 patients malignant T-cell skin lymphoma study, aged 38 to 82 years (29 mycosis fungoides patients, 2 lymphomatoid papulosis, 14 patients with primary anaplastic large cell skin lymphoma) received fast electrons total skin irradiation on the basis of the Federal State Institution «Russian Radiology and Surgical Technologies Scientific Center named after Academician A.M.Granov» of the Ministry of Health of the Russian Federation from 2012 to June 2022. Radiation therapy performed in the usual fractionation mode on linear electron accelerators Elekta Precise with 4–6 MeV bremsstrahlung total doses from 14 to 30 Gy (22±2.4 Gy). In order to identify the role of possible prognostic factors of skin toxicity — gender, age, body mass index (BMI), smoking status, lymphoma body surface area (BSA), the presence of concomitant diseases (diabetes mellitus and arterial hypertension) and previous chemotherapy.Statistics: Statistical analysis was performed using the IBM SPSS Statistics v. 26 program (developed by IBM Corporation). The value of p<0.05 was considered statistically significant. Verification of the sample belonging to the normal general population was carried out using the Shapiro–Wilk criterion. Spearman's rank correlation coefficient was used for correlation analysis. The regression parameters were estimated using the least squares method.RESULTS: The analysis revealed positive associations between the severity of RISR and predictor factors: BMI (r=0.799, p<0.01), smoking status (r=0.655, p<0.01), age (r=0.534, p<0.05), presence of diabetes mellitus (r=0.456, p<0.05), arterial hypertension (r=0.227, p<0.05), previous chemotherapy (r=0.422, p<0.01) and lymphoma body surface area (r=0.378, p<0.01). Severity of RISR scale value increase by those parameters. Negative links found between the severity of RISR and the total focal dose (SOD) of the beginning of their formation (r=–0.109, p<0.05).CONCLUSION: Formation and severity prognostic factors for the RCC upon fast electrons total skin exposure for patients with primary malignant T-cell skin lymphomas (mycosis fungoides, lymphomatoid papulosis, primary anaplastic large cell lymphoma of the skin) were identified.
Analyse de la contribution de l’enseignement des mathématiques sur la réussite scolaire des élèves de rhéto du lycée National Jean Jacques Acaau de Port-Margot
Authors: Myrtil Jonas 
Published: January 2023

Cet article a pour objectif de faire une analyse critique sur l’enseignement des Mathématiques à l’égard de la réussite scolaire des élèves du lycée National Jean Jacques Acaau de Port-Margot. Pour réaliser cette recherche, on a enquêté 25 élèves sur 51 de la classe de rhéto de l’établissement. Les élèves enquêtés ont été sélectionnés en fonction des critères suivants : leurs notes finales en mathématique, leur moyenne et leur participation durant le déroulement du cours. Pour essayer d’atteindre un résultat satisfaisant, on a observé le niveau de motivation des élèves durant les cours, ensuite on a aussi observé leur niveau de compréhension des contenus. Puis, on a vérifié les méthodes d’évaluation des apprenants. En matière de résultat global, on a pu constater que la majorité d’élèves déclare qu’ils aiment les mathématiques et arrivent à obtenir de notes satisfaisantes. Dans certains cas, une majeure partie des élèves déclarent qu’ils aiment les mathématiques alors qu’ils n’ont pas eu de bonnes notes ; cela est dû aux méthodes et aux pratiques utilisées par les professeurs.
Étude comparative de quatre (4) variétés de maïs (Zea mays L.) (MP1, MP2, HP2012 et Balaguel) au niveau de la 3e section communale de la commune de Hinche
Authors: Joseph Wendsley 
Published: January 2023

Cet article est un extrait d’une expérience réalisée à Papaye, une localité de la 3e section communale de la commune de Hinche, dans l’objectif d’étudier les différents paramètres de croissance et de développement entre quatre (4) variétés de maïs (Zea Mays L.) dont trois variétés introduites (MP1, MP2, HP2012) et une variété locale (Balaguel) tout en analysant les paramètres de rendement en vue de contribuer à la mise en place d’une fiche technique sur les variétés de maïs les plus adaptés dans la région. L’essai a été réalisé sur une superficie de 411,6 mètres carrés en adoptant le dispositif en blocs complets aléatoires. Les résultats obtenus au cours de cette expérience ont montré que le taux de levée a varié de 93,00 % (Balaguel) à 99,75 % (MP1). La hauteur prise au 60e jour a varié de 175,68 cm (MP1) à 196,68 cm (Balaguel) et le diamètre a oscillé de 1,26 cm (HP2012) à 2,8 cm (Balaguel). La variété HP2012 a été très peu sensible aux attaques des ravageurs par rapport aux deux autres variétés introduites, tandis que la variété locale (Balaguel) a été la plus touchée par l’attaque des ravageurs. En ce qui concerne le rendement en grain, les variétés de maïs introduites (MP1, MP2 et HP2012) ont fourni un niveau de rendement supérieur à celles de la variété locale (Balaguel). Compte tenu de la situation de la culture du maïs au niveau de la commune, les résultats de cette étude pourraient servir dans la prise de décision des décideurs haïtiens.
Introduction
Authors: Saint-Fleur Weldy 
Published: January 2023

Les textes présentés dans ce numéro spéciale intitulé : « Haïti et sa diversité scientifique : contributions à la pensée latino-américaine » s’inscrit à donner voix aux étudiants professeurs et chercheurs haïtiens à travers ce dossier. Ce volume présente des résultats diversifiés qui mobilisent plusieurs domaines de recherche et qui clarifient certains concepts visant à aider le développement scientifique haïtien déjà boiteux. Les critiques développées pourront aider à mieux comprendre les problèmes rencontrés dans l’agriculture, l’éducation, la santé, l’environnement – que se disputent les auteurs individuels ou collectifs. Il s’agit donc de valoriser et donner de la visibilité à des lieux et des groupes sociaux qui, historiquement, n’ont jamais occupé des espaces privilégiés où la parole est effectivement entendue. Nos auteurs abordent des problématiques diverses et fournissent un éclairage sur les aspects gouvernementaux, scientifiques et militants. En outre ils abordent la problématique socio-territorial d’Haïti la vulnérabilité du pays face à la pauvreté et aux changement climatiques. Leur analyse porte exclusivement sur Haïti. Nous croyons que leurs textes peuvent guider les différents acteurs (décideurs publics ou privé ou communauté locale porteuse d’intérêts divergents) et essentiellement contribuer au développement scientifique du pays et par ricochet le développement économique, social et environnemental.
PENGARUH PAPARAN MEDIA SOSIAL TERHADAP NIAT MENGUNJUNGI DESTINASI WISATA (STUDI PADA STUDIO ALAM GAMPLONG)
Authors: Wangka Handry Alvin , Krisjanti Mahestu Noviandra 
Published: January 2023

ABSTRACTThis study examines how the influence of social media exposure in shaping the behavior of tourists visiting the destination. The destination referred to in this study is a film tourism destination such as Studio Alam Gamplong and also how it affects the desires and gratification of destination content. Questionnaires were distributed as many as 202, but the number of samples used in this study were 173 respondents, respondents who had access to information about the Bumi Manusia and knew the Studio Alam Gamplong as the shooting location. The results of the study note that exposure to social media affects the intention to visit tourist destinations through the desire to travel and gratification of destination content, as well as the direct effect between social media exposure on the intention to visit tourist destinations. In addition, the mediation test results in a complementary and partial mediation model that can influence between independent variables on the dependent variable in the model both directly and indirectly. The desire to travel is an important variable in this study in formulating the intention of visiting tourists to the Studio Alam Gamplong.Keywords: social media exposure; desire to travel to destination; gratification destination content; intention to visit destination ABSTRAKPenelitian ini melihat bagaimana pengaruh paparan media sosial dalam membentuk perilaku wisatawan yang mengunjungi destinasi wisata. Destinasi wisata yang diteliti pada penelitian ini adalah destinasi wisata film seperti Studio Alam Gamplong dan pengaruhnya terhadap keinginan dan gratifikasi konten destinasi. Kuesioner yang dibagikan berjumlah 202, namun sampel dalam penelitian ini berjumlah 173 responden, yaitu para responden yang memiliki akses informasi tentang film Bumi Manusia dan mengetahui Studio Alam Gamplong sebagai tempat syuting film. Hasil penelitian ini menunjukkan bahwa paparan media sosial mempengaruhi niat mengunjungi destinasi wisata melalui keinginan untuk melakukan perjalanan dan gratifikasi konten destinasi, serta terdapat pengaruh langsung paparan media sosial pada niat mengunjungi destinasi wisata. Selain itu, hasil pengujian mediasi menunjukkan model mediasi komplementer dan parsial yang mempengaruhi hubungan antara variabel independen dan variabel dependen baik secara langsung maupun tidak langsung. Keinginan melakukan perjalanan merupakan variabel yang penting dalam penelitian ini di dalam merumuskan niat mengunjungi destinasi wisata Studio Alam Gamplong. Kata kunci: paparan media sosial; keinginan melakukan perjalanan; gratifikasi konten destinasi; niat mengunjungi destinasi
PERAN BRAND IMAGE DALAM MEMEDIASI KUALITAS DAYA TARIK WISATA TERHADAP NIAT BERKUNJUNG KEMBALI WISATAWAN NUSANTARA KE JATILUWIH, TABANAN, BALI
Authors: Pranata Rama Ady , Negara I Made Kusuma , Sudana I Putu 
Published: January 2023

This study aims to determine the role of Brand Image in mediating the influence of the quality of the Jatiluwih tourist attraction on the intention of returning domestic tourists to the Jatiluwih tourist attraction, Tabanan Regency. The sampling technique in this study was taken by purposive sampling with sample of 100 respondents, the respondent of this research were tourists who were visiting or had visited the tourist attraction of Jatiluwih. Meanwhile, this research is quantitative by using path analysis method as a data analysis technique. In this study using literature study techniques, interviews, observation and distributing questionnaires to obtain data. The results of the path analysis on the quality of tourist attractions have a direct influence on the intention to revisit and an indirect effect through Brand Image. The magnitude of the indirect effect coefficient can be calculated by multiplying the path coefficient from the quality of tourist attraction to Brand Image with the path coefficient from Brand Image to revisit intention of 0.474 x 0.389 = 0.184. The result of the indirect effect coefficient is smaller than the direct effect (0.184 < 0.728), so it can be said that the Brand Image variable is a mediating variable in mediating the influence of the tourist attraction quality variable on the return visit intention variable.
Role of fiberoptic bronchoscopy-guided needle aspiration cytology (EBNA) in diagnosing lung cancer in endobronchial lesions: A single-center experience
Authors: Patil Shital , Toshniwal Sham , Acharya Abhijit 
Published: January 2023

Objectives:
Globally, lung cancer is the leading cause of new cancer diagnosis and deaths. In spite of advancement in diagnostic modalities, lung cancer diagnosis is often delayed due to lack of bronchoscopy facility and techniques. In the present study, we have analyzed role of bronchoscopy in diagnosis of lung cancer with special emphasis on endobronchial needle aspiration (EBNA) cytology in comparison to other conventional diagnostic techniques (CDTs) such as bronchial wash (BW) and forcep biopsy (FB).

Material and Methods:
Prospective and observational study screened 1496 cases with suspected lung malignancy on clinical and radiological basis. Bronchoscopy guided techniques such as EBNA, BW, and FB are used in exophytic endobronchial lesions (EEL) in confirming the diagnosis of lung cancer and to find additive yield over other techniques such as BW and FB. Rapid on-site evaluation analysis of all EBNA samples done in pathology laboratory allied center. Finally, histopathology proven 893 lung malignancy cases are included in study. Statistical analysis is done using Chi-square test.

Results:
In the present study, 893 diagnosed lung cancer patients between 29 and 85 age groups; male is 60.02% (536/893) and females are 39.97% (357/893). Commoner radiological presenting features are mass lesion in 48.60% (434/893) cases, Hilar opacity in 33.37% (298/893) cases, and collapse segmental/lobar in 12.54% (112/893) cases. During bronchoscopy, anatomical location is documented on the right side of tracheobronchial in 57.33% (512/893) cases as compared to the left side of tracheobronchial wall 23.96% (214/893) and growth at carina documented in 18.70% cases (167/893) cases. Upper lobe bronchi are commoner site on both the sides as compared to other segmental bronchi. In the present study, yield of FB and FB plus BW in EEL is 84.65% (756/893) and 88.35% (789/893), respectively. Yield of EBNA, EBNA plus BW, and EBNA plus FB in EEL is 70.99% (634/893), 73.48% (656/893), and 99.66% (890/893), respectively. Overall, yield of all bronchoscopy guided techniques (EBNA + FB + BW) in our study in EEL is 100%. Additional yield of EBNA in EEL over other CDTs (CDTs such as FB plus BW) is 11.65%. Sensitivity of FB and EBNA in diagnosing lung malignancy in EEL is 84.65% and 70.99%, respectively. FB is more sensitive technique than EBNA in EEL (P < 0.00001). Sensitivity of FB plus BW in EEL is 88.35% (789/893). Sensitivity of EBNA plus BW in EEL is 73.48% (656/893). Sensitivity of EBNA plus FB in EEL is 99.66% (890/893) (P < 0.00001).

Conclusion:
EBNA has documented very crucial role in diagnosing lung cancer in comparison to other CDTs. Although FB is more sensitive test then EBNA in EEL in diagnosing disease, we have documented that EBNA has significant additive yield in proportionate number of cases. EBNA is safe, sensitive and cytology samples can give comparable results to histopathology.
Radicalisation among Students with Disabilities: Different Ways Government Can Support Schools and Teachers in Preventing Violence and Extremism
Authors: Faizan Zarish , Fatima Ghulam , Parveen Sajida 
Published: January 2023

Purpose: This research was an effort to address radicalisation among students with disabilities: Different ways government can support school and teachers in preventing violence and extremism.
Design/Methodology/Approach: The vast majority of the population was created by the special education teachers working in Punjab's public and private schools for disabled pupils. All special education teachers who work with a range of disabilities make up the study's population. A simple random selection method was used to choose a sample of 100 instructors. The tool was a self-structured questionnaire that was primarily divided into two sections: one section acknowledged the demographic characteristics of special education instructors, and the other asked participants' opinions on five-point Likert scales (Strongly Agree to Strongly Disagree) regarding risk factors for violence and extremism as well as potential guidelines for preventing violence and extremism. The questionnaire's reliability and validity were confirmed. Special educators gathered the data using face-to-face, telephone, email, social media, and online meetings. The gathered data were assessed using descriptive and inferential statistics in terms of frequencies and percentages.
Findings: The conclusions drawn demonstrated that students with disabilities were more highly probable to become radicalised when they experienced low self-esteem, mental health problems, traumatic experiences, childhood abuse, and family rejection, among other risk factors. These inferences were followed by recommendations for preventing violence and extremism.
Implications/Originality/Value: The Directorate General of Special Education and the administration of private special education institutions were exhorted to take prompt action to develop a school-based preventative programme for children with disabilities.
Ortodoksja katolicka i warunki jej rewizji w świetle krytycznej filozofii historii Henri-Irénée Marrou
Authors: Melonowska Justyna 
Published: January 2023

Celem artykułu jest przedstawienie koncepcji filozofii historii rozwijanej przez Henri-Irénée Marrou (1904–1977), który warunkiem poznania w dziedzinie historycznej czynił przyjaźń z historycznym Innym. Nieprzyjaźń i resentyment są zaś, jego zdaniem, czynnikiem rozumienie uniemożliwiającym. W świetle postulatu przyjaźni jako warunku poznania, artykuł analizuje przemiany stosunku do katolickiej ortodoksji w dziesięcioleciach poprzedzających sobór watykański II i postulaty jej porzucenia oraz całościowej rewizji warstwy doktrynalnej katolicyzmu i jego społecznej funkcjonalności. Jako że katolicyzm współczesny, szczególnie podczas trwającego pontyfikatu Franciszka, kładzie trwały akcent na zmianę i rewizję, w końcowej części artykułu sformułowano model przyjaznej rewizji, respektującej założenia krytycznej filozofii historii Marrou.
Characteristics of stress distribution of a multi layered cylindrical pressure vessel
Authors: Somnath Somadder  , Palash Das  , Md Ashraful Islam  
Published: January 2023

The operation of a multilayer pressure vessel subjected to thermomechanical loads is very significant. The cylindrical pressure vessel is widely used in industrial engineering, for example, to hold a variety of different types of liquid. On thick-walled cylinders, various loading circumstances such as internal overpressure, external overpressure, heat, bending, twisting, and combinations of these load characteristics are applied. Researchers have developed a number of strategies for enhancing the strength of cylinders, including the use of multilayer cylinders and increasing the thickness of the walls. This paper presents the results of an analytical and numerical analysis of a three-layer cylinder. Abaqus FEA software is used to determine temperature, displacement, and stress distribution of multilayer cylinder considering the effect of centripetal and centrifugal heat flow. From the numerical analysis it is observed that centrifugal heat flux is more hazardous than centripetal heat flux for multilayered cylinder under thermo-mechanical loading.
PENGARUH AKSEBILITAS, E-WOM DAN AMENITAS TERHADAP MINAT BERKUNJUNG WISATAWAN KE OBJEK WISATA AIR PANAS HAPANASAN
Authors: Aritona Aritona 
Published: January 2023

Penelitian ini bertujuan untuk mengetahui pengaruh aksebilitas, electronic word of mouth dan amenitas terhadap minat berkunjung wisatawan ke objek wisata air panas hapanasan. Populasi dalam penelitian ini adalah wisatawan yang berkunjung ke objek wisata air panas hapanasan. Sampel penelitian menggunakan teknik aksidental sampling dengan jumlah sebanyak 100 orang. Variabel bebas dalam penelitian ini aksebilitas (X1), electronic word of mouth (X2), amenitas (X3) dan variabel terikat minat berkunjung (Y). Metode pengumpulan data menggunakan observasi, kuesioner, wawancara dan dokumentasi. Analisis data menggunakan regresi linier berganda diperoleh persamaan regresi Y = 2,143 + 0,314 X1 + 0,541 X2 + 0,199 X3+ e. Secara parsial, diperoleh t-hitung aksebilitas 4,654, electronic word of mouth 7,525 dan amenitas 3,665. Secara simultan, diperoleh F-hitung 1716,39. Hasil penelitian ini baik pada pengujian secara parsial (uji t) maupun pengujian secara simultan (uji F) aksebilitas, electronic word of mouth dan amenitas berpengaruh signifikan terhadap minat berkunjung wisatawan ke objek wisata air panas hapanasan. Hasil uji koefisien determinasi menunjukkan bahwa 98,1% minat berkunjung dipengaruhi oleh aksebilitas, electronic word of mouth dan amenitas, sedangkan sisanya 1,9% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini.