bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-Analysis on Long-Term Outcomes of Pediatric Renal Cancer Survivors Following COG and SIOP Protocols
Authors: Raffaele Alessandro , Gazzaneo Marta , Busel Adi , Vatta Fabrizio , Belgiovine Cristina , Parigi Gian Battista , Riccipetitoni Giovanna 
Published: December 2022

Abstract
Background Pediatric renal cancer survivors have higher rate of chronic renal disease and hypertension. These patients have similar survival rates when treated according to either Children's Oncology Group (COG) or International Society of Pediatric Oncology (SIOP) protocols. We aimed to compare the late outcome of these two approaches.
Methods We performed a meta-analysis of all studies from 2000 to 2021; database search using keywords: long-term outcomes OR late effects, nephrectomy, pediatric renal cancer. For each protocol, data were collected, and the “pooled” outcomes were compared. Continuous and dichotomous variables were obtained with a 95% odds ratio.
Results Sixteen studies with a total of 715 pediatric renal cancer survivors were analyzed. The mean follow-up time was 17.4 (standard deviation 5.6) years. Reduced renal function and hypertension were the most encountered long-term complications. The mean estimated glomerular filtration rate was similar in both protocols (101.62 vs. 101.70 mL/min/1.73 m2), while the prevalence of hypertension was 23% in COG and 10% in SIOP. The prevalence of secondary malignancy was 1.1% in COG and 6.7% in SIOP (1.1% vs. 6.7%, p ≤ 0.001). Chronic kidney disease was similar in both groups.
Conclusion A high prevalence of hypertension was observed among pediatric renal cancer survivors, as well as an increased risk of a secondary tumor. These results emphasize the importance of long-term follow-up into adulthood, to promptly diagnose any long-term side effects of the treatment. Thanks to the increased overall survival, future protocols will pay attention to the reduction of long-term sequelae.
The Impact of the COVID-19 Pandemic on Injury Patterns in Inpatient and Outpatient Orthopaedic Trauma
Authors: Gatt Thomas , Zammit Sharon , Chircop Kurt L. , Gatt Denise , Sultana Luke , Micallef Terence , Grech Adriana , Esposito Ivan 
Published: December 2022

AbstractThe effect of banning of nonessential services during the novel coronavirus disease 2019 (COVID-19) pandemic led to a perceived change in the volume of trauma cases and injury patterns. Literature indicates trends toward less trauma overall, with a decrease in outdoor, sporting, and motor vehicle injuries. However, studies focusing on outpatient orthopaedic trauma are less common. The main aim of this study was to assess the effect of COVID-19 pandemic on differences in inpatient and outpatient injury patterns and mechanisms. Patients requiring orthopaedic inpatient admission to Mater Dei Hospital, Malta, were analyzed between March 15 and June 17 between 2019 and 2021. For outpatients, all newly referred patients seen at the fresh trauma clinic (FTC) on the first 5 clinic days of each month from April to June between 2019 and 2021 were assessed. There were a total of 503, 362, and 603 hospital admissions during the data collection period from 2019, 2020 and 2021, respectively. There was a decrease in elbow (p = 0.015) and pelvis (p = 0.038) pathology since COVID-19 pandemic. In contrast, there was an increase in shoulder injuries (p = 0.036) and lacerated wounds (p = 0.012) in 2021. The most frequent mechanisms of injury for inpatients were low impact falls, and fall from heights greater than 1 m. Machine-related injuries (p = 0.002), blunt trauma (p = 0.004), and twisting injuries (p = 0.029) increased in 2021. In the outpatient setting, there were a total of 367, 232, and 299 new referrals in 2019, 2020, and 2021, respectively. Injury patterns in this cohort were similar throughout, except for a significant increase in shoulder injuries during 2020 (p = 0.009). There appears to be some minor variation in injury mechanisms due to lifestyle changes; however, most injury patterns have remained fairly constant. Further research should focus on the use of public awareness campaigns to decrease home-related trauma during enforced periods of lockdown.
Effect of Decompressive Craniectomy with Stepwise Decompression of the Intracranial Compartment on Postoperative Neurologic Function, Hemodynamics, and Glasgow Outcome Scale Score of Patients with Severe Traumatic Brain Injury
Authors: Wu Huayong , Jiang Bingjie , Yan Xinjiang , Zhan Chengpeng , Dai Weimin , Yu Guofeng 
Published: December 2022

Abstract
Background We assess the effects of standard decompressive craniectomy with stepwise decompression of the intracranial compartment on the postoperative neurologic function, hemodynamics, and Glasgow Outcome Scale (GOS) score of patients with severe traumatic brain injury (sTBI).
Methods One hundred sTBI patients admitted from July 2017 to February 2019 were enrolled and randomly divided into step and standard groups (n = 50) using a random number table. The standard group received traditional standard decompression during surgery, while the step group underwent multistep decompression during surgery. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were measured immediately after surgery (T0), 3 hours after surgery (T1), 6 hours after surgery (T2), and 12 hours after surgery (T3). The postoperative Glasgow Coma Scale (GCS) score, neurologic function deficit score, and GOS score were evaluated.
Results After treatment, the excellent/good rate of neurologic function improvement and GCS and GOS scores of the step group significantly exceeded those of the standard group (p < 0.05). Compared with the standard group, the HR, SBP, DBP, and MAP decreased significantly in the step group at T1, T2, and T3 (p < 0.05).
Conclusion Standard decompressive craniectomy under multistep decompression can markedly improve the neurologic function, hemodynamics, and prognosis of patients.
Preterm Birth Rates after Initiating the Third-Trimester Screening Protocol of Samrakshan in India: Initial Results
Authors: Choorakuttil Rijo Mathew , Rajalingam Bavaharan , Satarkar Shilpa R. , Sharma Lalit K. , Gupta Anjali , Baghel Akanksha , Nirmalan Praveen K. 
Published: December 2022

Abstract
Aim To determine the trends in preterm birth (PTB) rates in Samrakshan after initiating a third-trimester screening protocol.
Methods The Samrakshan program of IRIA focused on clinical stage-based management of fetal growth restriction (FGR) in the third trimester integrating fetal Doppler studies with routine trimester-specific antenatal scans. Mean uterine artery pulsatility index (PI), umbilical artery PI, middle cerebral artery PI, and cerebroplacental ratio were assessed for all third-trimester pregnant women in the program.
Results From 2019 to 2022, 249 (18.33%, 95% CI: 16.34, 20.54) women had PTB with 221 (16.67%, 95% CI: 14.73, 18.75) PTBs between 34 and 37 gestation weeks and 22 (1.66%, 95% CI: 1.10, 2.50) PTBs at gestation < 34 weeks. The overall preterm birth rates showed a significant (chi-square p < 0.001) declining trend each year from 23.18% (n = 121) in 2019–2020 to 16.81% (n = 99) in 2020–2021 and 10.75% (n = 23) in 2021–2022.
Conclusion The declining trend of PTB rates in the Samrakshan program shows that the reduction of PTB is an added benefit of the integration of fetal Doppler studies in the third trimester of pregnancy.
Joubert Syndrome: Diagnostic Evaluation and Follow-up
Authors: Cuppari Caterina , Ceravolo Ida , Mancuso Alessio , Farello Giovanni , Iapadre Giulia , Zagaroli Luca , Nanni Giuliana , Ceravolo Maria Domenica 
Published: December 2022

AbstractThe follow-up of a child with genetic syndrome is necessarily multidisciplinary because of the multiplicity of problems and calls for close collaboration between different specialists. The primary objective is the total care of the child and his family, regardless of the rarity and complexity of the disease, to obtain the highest possible degree of mental and physical health and autonomy.
A Decade of Imaging Patients with Traumatic Brachial Plexopathy: What have We Learned?
Authors: Upadhyaya Vaishali , Upadhyaya Divya Narain , Mishra Abhijat 
Published: December 2022

Abstract
Aim In this paper, the authors share their experience of imaging patients with traumatic brachial plexopathy by magnetic resonance neurography (MRN) spanning over a period of nearly 10 years.
Setting and Design This was a single-institution, prospective, observational study conducted between August 2012 and March 2022.
Materials and Methods Children and adults presenting to the plastic surgery outpatient department with features of traumatic brachial plexopathy were included in the study. The MRN study was performed in a 1.5T scanner (Magnetom Essenza, Siemens, Erlangen, Germany). The area scanned extended from C3 level to T3 level.
Statistical Analysis Descriptive statistics (percentages, mean, median, and mode).
Results A total of 134 patients (n = 134) were included in the study. The age of our patients ranged from 6 months to 65 years. The mean age was 24.95 ± 12.10 years, with a median of 23 years. All patients had unilateral injury, and the right side was more commonly involved. Road traffic accident was the most common mode of injury, and blunt crush-avulsion was the most common mechanism of injury. Involvement of shoulder, elbow, and hand together (panplexopathy) was the most common clinical presentation.
Conclusion This study of patients with traumatic brachial plexopathy imaged by MRN, spanning nearly a decade, has led to several interesting observations. The majority of these injuries occur in young men from urban areas who usually present with panplexopathy. The most common mode of injury is road traffic accident, and blunt crush-avulsion is the most common mechanism of injury.
Experience with Methicillin-Resistant Staphylococcus aureus in a Central London Tertiary Pediatric Hospital
Authors: Chahal Kayden , Omran Kareem , Vora Rakesh , Upadhyaya Manasvi 
Published: December 2022

Abstract
Objective Methicillin-resistant Staphylococcus aureus (MRSA) infection is very serious, and thus, it is common practice, worldwide, to screen for MRSA colonization at admission and institute decolonization procedures. Our aim was to review adherence to local guidelines and sepsis risk in pediatric patients with a focus on surgical cases.
Methods A retrospective case note review was conducted from January 2019 to October 2020 in a tertiary pediatric hospital. Data collected included demographics, incidence of sepsis, pediatric intensive care unit (PICU) admissions, and adherence to guidelines. The results were analyzed with an SPSS statistical package.
Results MRSA screening was performed in all 47,904 admissions; 161/47,904 had MRSA colonization. All underwent topical decontamination; however, isolation guidelines were adhered in only 7.45%; 71/161 were surgical patients; 23/71 were admitted to the PICU. Irrespective of the class of wound, 4/71 surgical patients developed MRSA sepsis. Of these, 2/5 surgical patients did not receive MRSA appropriate preoperative antibiotics; 4/5 surgical patients who had sepsis were admitted to PICU. Standard preoperative World Health Organization (WHO) surgical checklists were completed in all surgical cases. There was no mention of MRSA status in these forms.
Conclusion MRSA remains a risk for sepsis and PICU admissions despite a 100% compliance with screening and decontamination. Adherence to WHO checklist did not result in the administration of correct antibiotics. High risk of postoperative sepsis (6.8%), with 80% needing PICU, irrespective of class of wound, mandates a more robust approach to prevention. Changes need to be made to WHO local surgical checklists.
Association of Tumor Necrosis Factor-Alpha (TNF-α) and Suppressor of Cytokine Signaling-1 (SOCS-1) Gene Variants in Children with COVID-19
Authors: Uysalol Metin , Serin Istemi , Oyacı Yasemin , Yıldız Raif , Uysalol Ezgi , Pehlivan Sacide 
Published: December 2022

Abstract
Objective The suppressor of cytokine signaling-1 (SOCS-1) gene is an essential physiological regulator of cytokine signaling. Tumor necrosis factor-α (TNF-α) is an important component of the immunological response. Herein, we aimed to investigate the effects of SOCS-1 (-1478 CA > Del) and TNF-α (-308) polymorphisms on disease susceptibility and prognosis in pediatric patients with coronavirus disease 2019 (COVID-19).
Methods One-hundred fifty COVID-19 patients in the COVID-19 emergency department between September 2020 and April 2021 and 80 healthy volunteers (control group) without any additional disease were included. Baseline gene polymorphisms were compared between the patient and healthy control groups. Afterward, the gene polymorphism distribution was examined by forming two separate clinical patients' subgroups.
Results While CA/CA and CA/Del gene variants of SOCS-1 were higher in the patient group, Del/Del genotype was more common in the control group (p < 0.05). The GG genotype of the TNF-α was significantly more common in the severe subgroup (p = 0.044). The GA genotype of TNF-α was associated with the risk of hospitalization (2.83-fold), while the GG genotype was found to be protective in terms of hospitalization (2.95-fold).
Conclusions This study will be a guide in terms of the presence of high cytokine release genotypes and COVID-19-related cytokine release syndromes.
Accessing Intraabdominal Abscess for Percutaneous Drainage Using a Trocar Only Technique to Maneuver Intervening Bowel
Authors: Hussain Hafsa , Deek Feras , Efridi Wajahat , Shaikh Azim , Syed Mubin 
Published: December 2022

AbstractConventional approaches to the drainage of abscess surrounded by bowel contraindicate percutaneous drainage and often involve more invasive laparotomy. We attempt to demonstrate the use of an image-guided blunt trocar to navigate obstructive bowel and access abdominal abscess. This report presents the use of a blunt trocar to safely maneuver obstructive bowel and perform successful percutaneous drainage of intraabdominal abscess in two separate cases: one presenting a left lower quadrant diverticular abscess and the other presenting an abscess in the right lower quadrant. Thus, traversing obstructive bowel using a blunt trocar under computed tomography-guidance allows for percutaneous drainage of an intraabdominal abscess, and provides a safer and more effective alternative to more invasive procedures.
Small Bowel Obstruction Secondary to Traumatic Incarceration Between Vertebral Fracture: A Case Report in a Tertiary Care Hospital in Central India
Authors: Halder Koushiki , Sarjare Deoyani , Anand Aarti 
Published: December 2022

AbstractBowel injury secondary to blunt trauma abdomen is a commonly encountered entity. However, small bowel obstruction secondary to traumatic incarceration of bowel loops between two translated vertebras in a case of road traffic accident is seldom reported. We report a case of small bowel obstruction in a patient who had suffered spondyloptosis at the L1–L2 level after a motor vehicle accident. We also discuss the diagnostic work up and interventions done to manage the patient. The report also reviews pertinent published literature on the incarceration of the bowel associated with vertebral fractures.
The Pelican Sign: Case Series Demonstrating A Unique Description of an Anteriorly Flipped Bucket-Handle Meniscal Tear of the Knee
Authors: Shah Ali , Iyengar Karthikeyan P. , Gavvala Sai Niharika , Shah Amit , Beale David , Botchu Rajesh 
Published: December 2022

Abstract
Introduction Bucket-handle tears (BHTs) of the menisci are not uncommon and can occur in isolation or in conjunction with other injuries. The torn fragment can be displaced within the intercondylar notch or flipped anteriorly. In case of anterior flipped fragment, appearances of such tears on magnetic resonance imaging (MRI) scan have been described as various signs in literature (for example double posterior cruciate ligament sign, double delta sign) but mostly in the sagittal or coronal planes.
Purpose The aim of this study was to describe a unique ancillary sign that helps to identify this injury on the axial MRI plane where the anterior flipped BHT figuratively resembles a “pelican bird.”
Materials and Methods A retrospective review of MRI sequences of 10 consecutive patients over a 3-month period referred following a traumatic knee injury with anterior flipped meniscal tears was performed. Demographic details, clinical indication, and other associated features on the MRI were correlated following the observation of characteristic MRI appearance of a BHT.
Results All 10 patients (M:F = 7:3) with a mean age of 24.7 (17–38 years) presented following a twisting injury. 6 out of 10 patients had associated soft-tissue injuries in the knee visualized on the MRI. All patients demonstrated the distinctive “pelican bird” sign on the axial sequences of anterior flipped BHT of either menisci. This was not present with BHTs with displaced fragment within the intercondylar notch.
Conclusion We conclude that the “pelican sign” on an axial sequence when present correlates well with a BHT and its anterior displaced/flipped meniscal fragment. This ancillary sign can complement other previously described signs on different MRI sequences used to confirm a displaced BHT.
Gigahertz elastic modulus and OH stretching frequency correlate with Jones–Dole’s B-coefficient in aqueous solutions of the Hofmeister series
Authors: Dobrynina E. A. , Zykova V. A. , Adichtchev S. V. , Surovtsev N. V. 
Published: December 2022

The ability of salts to change the macroscopic viscosity of their aqueous solutions is described by the Jones–Dole equation with B-coefficient for the linear concentration term. The sign and value of this coefficient are often considered as a measure of the salt’s structure-making/breaking ability, while the validity of this assignment is still under discussion. Here, by applying Raman and Brillouin scattering spectroscopy to various salts from the Hofmeister series, we studied a possible relation between macroscopic Jones–Dole’s B-coefficient and the microscopic dynamic response. Raman spectroscopy provides information about molecular vibrations and Brillouin spectroscopy about acoustic phonons with wavelengths of hundreds of nanometers. It has been found that Jones–Dole’s B-coefficient correlates linearly with the coefficients, describing the concentration dependences of the average OH stretching frequency, real and imaginary parts of gigahertz elastic modulus. These relationships have been interpreted to mean that the OH stretching frequency is a measure of the ion-induced changes in the water network that cause changes in both viscosity and gigahertz relaxation. Depolarized inelastic light scattering revealed that the addition of structure-making ions not only changes the frequency of the relaxation peak but also increases the low-frequency part of the relaxation susceptibility. It was shown that the ion-induced increase in the gigahertz elastic modulus can be described by changes in the relaxational susceptibility without a noticeable change in the instantaneous elastic modulus. The isotropic Raman contribution associated with the tetrahedral-like environment of H2O molecule does not correlate with Jones–Dole’s B-coefficient, suggesting a minor influence of these tetrahedral-like configurations on viscosity.
Comment on ‘Sliding down over a horizontally moving semi-sphere’
Authors: Yu-Kuang Hu Ben 
Published: December 2022

Abstract
In a recent paper (2022 Eur. J. Phys. 43 035 004) Lineros considers a block (not necessarily initially at rest) which slides down from the top of a frictionless horizontal movable semi-sphere. The author studies the angle at which the block loses contact with the sphere and derives a cubic equation which determines that angle. In this comment, a considerably more elementary derivation of that result is presented.
Chip for dielectrophoretic microbial capture, separation and detection I: theoretical basis of electrode design
Authors: Weber Monika U , Petkowski Janusz J , Weber Robert E , Krajnik Bartosz , Stemplewski Slawomir , Panek Marta , Dziubak Tomasz , Mrozinska Paulina , Piela Anna , Lo Siu Lung , Montanaro Ochoa Hazael F , Yerino Christopher D 
Published: December 2022

Abstract
We model the dielectrophoretic response of E. coli bacterial cells and red blood cells, upon exposure to an electric field. We model the separation, capture, and release mechanisms under flow conditions in a microfluidic channel and show under which conditions efficient separation of different cell types occurs. The modelling work is aimed to guide the separation electrode architecture and design for experimental validation of the model. The dielectrophoretic force is affected both by the geometry of the electrodes (the gradient of the electric field), the Re{CM(ω)} factor, and the permittivity of the medium ϵm. Our modelling makes testable predictions and shows that designing the electrode structure to ensure structure periodicity with spacing between consecutive traps smaller than the length of the depletion zone ensures efficient capture and separation. Such electrode system has higher capture and separation efficiency than systems with the established circular electrode architecture. The simulated, modelled microfluidic design allows for the separated bacteria, concentrated by dedicated dielectrophoretic regions, to be subsequently detected using label-free functionalized nanowire sensors. The experimental validation of the modelling work presented here and the validation of the theoretical design constraints of the chip electrode architecture is presented in the companion paper in the same issue (Weber MU et al 2022 Chip for dielectrophoretic Microbial Capture, Separation and Detection II: Experimental Study).
Fe3O4@uio66 core-shell composite for detection of electrolyte leakage from lithium-ion batteries
Authors: Zhang Erpan , Yan Wenjun , Zhou Shiyu , Ling Min , Zhou Houpan 
Published: December 2022

Abstract
Fe3O4 is an environmentally friendly gas sensing material with high response, but the cross-response to various analytes and poor thermal stability limit its practical applications. In this work, we prepared Fe3O4@uio66 core–shell composite via a facile method. The selective response to volatile organic compounds, especially to electrolyte vapors of lithium-ion batteries, as well as long-term stability of Fe3O4@uio66 has been dramatically enhanced compared to pure Fe3O4, due to the preconcentrator feature and thermal stability of the uio66 thin shell. Real-time detection of electrolyte leakage for an actual punctured lithium-ion battery was further demonstrated. The Fe3O4@uio66 sensor, after aging for 3 months, was able to detect the electrolyte leakage in 30 s, while the voltage of the punctured battery was maintained at the same level as that of a pristine battery over 6 h. This practical test results verified ability of the Fe3O4@uio66 sensor with long-term aging stability for hours of early safety warning of lithium-ion batteries.