bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loco-regional treatment with temozolomide-loaded thermogels prevents glioblastoma recurrences in orthotopic human xenograft models
Authors: Gherardini Lisa , Vetri Buratti Veronica , Maturi Mirko , Inzalaco Giovanni , Locatelli Erica , Sambri Letizia , Gargiulo Sara , Barone Virginia , Bonente Denise , Bertelli Eugenio , Tortorella Silvia , Franci Lorenzo , Fioravanti Antonio , Comes Franchini Mauro , Chiariello Mario 
Published: March 2023

AbstractGlioblastoma multiforme (GBM) is the most aggressive primary tumor of the central nervous system and the diagnosis is often dismal. GBM pharmacological treatment is strongly limited by its intracranial location beyond the blood–brain barrier (BBB). While Temozolomide (TMZ) exhibits the best clinical performance, still less than 20% crosses the BBB, therefore requiring administration of very high doses with resulting unnecessary systemic side effects. Here, we aimed at designing new negative temperature-responsive gel formulations able to locally release TMZ beyond the BBB. The biocompatibility of a chitosan-β-glycerophosphate-based thermogel (THG)-containing mesoporous SiO2 nanoparticles (THG@SiO2) or polycaprolactone microparticles (THG@PCL) was ascertained in vitro and in vivo by cell counting and histological examination. Next, we loaded TMZ into such matrices (THG@SiO2-TMZ and THG@PCL-TMZ) and tested their therapeutic potential both in vitro and in vivo, in a glioblastoma resection and recurrence mouse model based on orthotopic growth of human cancer cells. The two newly designed anticancer formulations, consisting in TMZ-silica (SiO2@TMZ) dispersed in the thermogel matrix (THG@SiO2-TMZ) and TMZ, spray-dried on PLC and incorporated into the thermogel (THG@PCL-TMZ), induced cell death in vitro. When applied intracranially to a resected U87-MG-Red-FLuc human GBM model, THG@SiO2-TMZ and THG@PCL-TMZ caused a significant reduction in the growth of tumor recurrences, when compared to untreated controls. THG@SiO2-TMZ and THG@PCL-TMZ are therefore new promising gel-based local therapy candidates for the treatment of GBM.
Gravity complexes as a focus of seafloor fluid seepage: the Rio Grande Cone, SE Brazil
Authors: Ketzer M. , Praeg D. , Augustin A. H. , Rodrigues L. F. , Steiger A. K. , Rahmati-Abkenar M. , Viana A. R. , Miller D. J. , Malinverno A. , Dickens G. R. , Cupertino J. A. 
Published: March 2023

AbstractSeafloor methane emissions can affect Earth’s climate and ocean chemistry. Vast quantities of methane formed by microbial decomposition of organic matter are locked within gas hydrate and free gas on continental slopes, particularly in large areas with high sediment accumulations such as deep-sea fans. The release of methane in slope environments has frequently been associated with dissociation of gas hydrates near the edge of the gas hydrate stability zone on the upper slope, with discharges in greater water depths less understood. Here we show, using data from the Rio Grande Cone (western South Atlantic), that the intrinsic, gravity-induced downslope collapse of thick slope sediment accumulations creates structures that serve as pathways for gas migration, unlocking methane and causing seafloor emissions via giant gas flares in the water column. The observed emissions in the study region (up to 310 Mg year−1) are three times greater than estimates for the entire US North Atlantic margin and reveal the importance of collapsing sediment accumulations for ocean carbon cycling. Similar outgassing systems on the Amazon and Niger fans suggest that gravity tectonics on passive margins is a common yet overlooked mechanism driving massive seafloor methane emissions in sediment-laden continental slopes.
A Critique of the National Academies of Sciences, Engineering, and Medicine Report (2021) and the Diagnostic Accuracy of Measurements of Functional Hearing Ability
Authors: Vermiglio Andrew J. 
Published: March 2023

Purpose:
The Social Security Administration (SSA) asked the National Academies of Sciences, Engineering, and Medicine (NASEM, 2021) to make recommendations for tests of functional hearing ability. These tests include speech perception measures administered in quiet and in background noise. Such tests are required to make disability determinations for adults and children following cochlear implantation. The test review required an evaluation of the diagnostic accuracy of the speech perception measures. Following a review of the literature, NASEM wrote that the evidence needed to support such a recommendation was lacking. They resorted to “professional judgment” and recommended a monosyllabic word recognition test, presumably in quiet, along with a measure of self-report or parent report. The primary purpose of this article was to critically review the committee's report. The secondary purpose was to critique the committee's recommendation of a monosyllabic word test as a measure of functional hearing ability for disability determinations. The third purpose was to provide a review of diagnostic accuracy studies not included in NASEM (2021) with an emphasis on speech recognition in noise (SRN) tests.

Conclusions:
In contrast to the committee's recommendation, studies have shown that a monosyllabic word test is a poor predictor of SRN ability. Contrary to the conclusion of NASEM (2021), diagnostic accuracy studies have been conducted for a few SRN tests. The Hearing in Noise Test and the AzBio SRN test have published data demonstrating their ability to correctly identify the presence and absence of an SRN disorder.
Pb2+ recovery from real water samples by adsorption onto nano Fe3O4/chitosan‐acrylamide hydrogel ions in real water samples
Authors: Samadzadeh Mamaghani Arman , Manafi Mohammadreza , Hojjati Mohammad 
Published: March 2023

AbstractThis study examined the removal of Pb(II) using magnetic chitosan hydrogel adsorbent from diverse sample waters. Spectrometry was used to track the effects of magnetic acrylamide nanocomposite dose, pH extraction, and contact duration on Pb(II) removal from sample water. This research also looked at adsorption isotherm models for the sorption of Pb(II). The magnetic chitosan hydrogel adsorbent Pb(II) adsorption capability was 31.74 mg/g respectively. The Freundlich isotherm model fits the removal of Pb(II) utilising magnetic chitosan hydrogel adsorbent. In addition, this adsorbent was shown to have a qmax value of 31.74 mg/g of Pb2+ ions, which is considered to be of high efficiency for Pb2+ ion removal. The studied kinetic models have determined that the pseudo‐second‐order linear model is more suitable to explain the adsorption of lead (II) on magnetic chitosan hydrogel adsorbent. Also, chemical adsorption is the rate‐limiting step in the adsorption process of lead (II) ions.
Impedance matching for curl and truncated spiral antennas above the ground plane
Authors: Hirose Kazuhide , Ito Naonoshin , Nakano Hisamatsu 
Published: March 2023

AbstractCurl and truncated spiral antennas are studied for input impedance matching a coaxial line. Each antenna is located at quarter wavelengths above the ground plane and analyzed using the moment method. It is found that the curl antenna shows a voltage standing wave ratio (VSWR) of less than two in a 3‐dB axial ratio bandwidth of 30% using a crank feedline with an unbalanced feed. It is also found that the spiral antenna has an axial ratio bandwidth of 24%, where the VSWR remains less than two using parallel feedlines with a quasi‐balanced feed.
Maladie rénale chronique et retard de croissance
Authors: Bechara Rouba , Rossignol Sylvie , Zaloszyc Ariane 
Published: March 2023

Le retard de croissance est une des complications les plus fréquentes chez l’enfant présentant une maladie rénale chronique. Il est corrélé à une morbi-mortalité importante, augmentée par les désordres métaboliques qui y sont associés. D’origine multifactorielle, une hypothèse régulièrement avancée est celle d’une résistance à l’hormone de croissance (GH), caractérisée par un déficit en IGF1 (insulin-like growth factor 1). L’obtention d’une croissance staturale satisfaisante reste un défi majeur pour les néphropédiatres. La prise en charge du retard statural comprend différents axes thérapeutiques : une nutrition adaptée aux besoins de l’enfant, une correction des troubles métaboliques avec optimisation de la dialyse, et un traitement par hormone de croissance recombinante à dose supra-physiologique, qui permet de lever la résistance.
Nuklearmedizinische Strahlenexpositionen während der Schwangerschaft
Authors: Happel Christian , Borowski Markus , Gröner Daniel , Kamp Alexandra , Brix Gunnar , Grünwald Frank , Fiebich Martin 
Published: March 2023

ZusammenfassungIn medizinisch begründeten Einzelfällen oder bei unbekannter Frühschwangerschaft kann es
durch die Applikation offener radioaktiver Stoffe in der Nuklearmedizin zu einer pränatalen
Strahlenexposition kommen. Die von Metabolisierung und Biodistribution abhängende Dosis für
das Ungeborene kann messtechnisch nicht ermittelt werden. Eine möglichst valide Abschätzung
der Dosis ist daher von großer Relevanz. Die Abschätzung erfolgt üblicherweise mit den
biokinetischen und dosimetrischen Modellen der ICRP. Bei der Hybridbilddiagnostik muss
zusätzlich auch die Strahlenexposition durch die radiologische Komponente berücksichtigt
werden. Die Aktivität der im Rahmen einer nuklearmedizinischen Diagnostik applizierten offenen
radioaktiven Stoffe führt üblicherweise zu einer Dosis des Ungeborenen von weniger als 20mSv.
Relevante deterministische Strahlenwirkungen sind hier auszuschließen. Es ergeben sich keine
praktischen Konsequenzen für den weiteren Verlauf der Schwangerschaft. Bei höheren Dosiswerten
für das Ungeborene, wie sie insbesondere bei der therapeutischen Anwendung offener
radioaktiven Stoffe bei unbekannter Schwangerschaft auftreten können, kann jedoch eine Dosis
von 100mSv für das Ungeborene überschritten werden, welche als Schwelle für die Induktion von
anatomischen Fehlbildungen, Wachstumshemmungen und funktionellen Störungen gilt.
Dosimetrie bei der Peptid-Radio-Rezeptor-Therapie (PRRT)
Authors: Delker Astrid 
Published: March 2023

ZusammenfassungDie Peptid-Radio-Rezeptor-Therapie (PRRT) hat sich in den letzten Jahren als vielversprechende Therapieoption des inoperablen metastasierten neuroendokrinen Tumors (NET) entwickelt. In Form von Radiotherapeutika wie 177Lu-DOTATATE oder 90Y-DOTATOC kombiniert die PRRT strahlentherapeutische und pharmakologische Prinzipien, um eine selektive und interne Bestrahlung von NET unabhängig von deren Lokalisation im Körper zu ermöglichen. Die patientenspezifische Dosimetrie ist dabei ein elementarer Bestandteil der Patientensicherheit, ermöglicht aber auch grundlegende Wirkmechanismen der PRRT zu identifizieren sowie das therapeutische Fenster optimal auszuschöpfen. Dieser Übersichtsartikel soll die Grundlagen der patientenspezifischen Dosimetrie für die PRRT beleuchten sowie den aktuellen Stand der Forschung zur patientenspezifischen Dosimetrie innerhalb der klinischen Routine der PRRT.
Bildgebung, Kinetik, Quantifizierung
Authors: Braune Anja , Großer Oliver S. 
Published: March 2023

ZusammenfassungNuklearmedizinische tomografische Verfahren wie die Positronen-Emissions-Tomografie (PET) und Single-Photonen-Emissions-Computertomografie (SPECT) werden in einem quantitativen Setting genutzt (z. B. die PET) bzw. sind, wie im Fall der SPECT, aufgrund der Erfordernisse nuklearmedizinischer Therapien an eine bildbasierte Dosimetrie, als quantitative bildgebende Modalität zu etablieren. Für die quantitative Analyse der bereitgestellten Bilddaten existieren unterschiedliche Konzepte. Ausgehend von der Quantifizierung dynamischer Aufnahmen mittels der Zeitaktivitätskurve wird für die kinetische Modellierung die Patlak-Methode vorgestellt. Verschiedene Methoden zur Auswertung statischer PET-Messungen, wie der Standardized Uptake Value (SUV) und das Standardized Uptake Ratio (SUR), werden diskutiert. Für die SPECT werden exemplarisch verschiedene methodische Entwicklungen auf dem Weg zur quantitativen Modalität adressiert.
Myasthenia Gravis and Abdominal Aortic Aneurysm: A Rare Combination
Authors: Papadoulas Spyros , Zotou Anastasia , Kouri Natasa , Tsimpoukis Andreas , Zampakis Petros , Koutsogiannis Nikolaos , Chroni Elisabeth 
Published: March 2023

AbstractAbdominal aortic aneurysm in a patient with myasthenia gravis (MG) is extremely rare. We present a 64-year-old male with MG and an asymptomatic abdominal aortic aneurysm treated endovascularly. After extubation, he suffered a cardiac arrest due to an acute myocardial infarction. Cardiopulmonary resuscitation and a primary coronary angioplasty led to a satisfactory outcome. Special care is needed due to higher rates of postoperative complications in these patients.
Resistance Training Improves Hypertrophic and Mitochondrial
Adaptation in Skeletal Muscle
Authors: Zhao Yong-Cai , Wu Yan-Yan 
Published: March 2023

AbstractResistance training is employed for pursuing muscle strength characterized by
activation of mammalian target of rapamycin (mTOR)-mediated hypertrophic
signaling for protein production. Endurance training elevates peroxisome
proliferator-activated receptor γ coactivator 1α
(PGC-1α) signaling of mitochondrial adaptations for oxidative
phosphorylation. Now, emerging evidence suggests that, like endurance training,
resistance training also elicits profound effects on mitochondrial adaptations
in skeletal muscle, which means that resistance training yields both strength
and endurance phenotypes in myofibers, which has treatment value for the muscle
loss and poor aerobic capacity in humans. Our review outlines a brief overview
of muscle hypertrophic signals with resistance training, and focuses on the
effects of resistance training on mitochondrial biogenesis and respiration in
skeletal muscle. This study provides novel insights into the therapeutic
strategy of resistance training for the metabolically dysfunctional individuals
with declined mitochondrial function.
Infiltrative Intramuscular Lipoma in the Antebrachium of a Dog
Authors: Tirillini Francesca , Clarke Stephen , Ferreira Amy , Baines Stephen J. 
Published: March 2023

AbstractThis case report describes a dog with an infiltrative intramuscular lipoma in the antebrachium, presenting with chronic left forelimb lameness and altered posture of the digits. Computed tomography showed a fat-attenuating mass displacing the flexor tendons. The mass was surgically excised along with the affected muscle belly and tendon; histopathological examination revealed infiltration of adipose tissue cells within the muscle belly and tendon sheath of the deep digital flexor muscle. After removal of the lipoma, lameness resolved, full ambulatory function returned, without recurrence at 1 year follow-up.
PER Informed “Physics Teaching”—Coordinating Learning Goals and Teaching Practices
Authors: Yerushalmi Edit , Eylon Bat Sheva 
Published: March 2023

This chapter discusses three major questions guiding research-informed “physics teaching:”What learning goals should physics teaching aim at? What processes and conceptual frameworks involved in doing physics should be targeted at different educational stages?What should physics teaching consider as the foundation it builds on? How should it respond to different students” views and approaches toward the learning and doing of physics?What characterizes the learning processes that allow students to transition from one “state” to the other, and what instructional interactions support these processes?
It describes how the chapters in the third section of the IPHER handbook (2022) are organized in four branches to address these questions: Physics teaching aimed at developing core scientific practices; Physics teaching aimed at extending the scope of the current introductory-level curricula; Physics teaching considering the vertical and horizontal integration of Physics in K-12 curricula; and research considering effective instruction and teaching practices.
We conclude with insights from the educational literature concerning the central “change agents”—teachers and researchers—who are essential in a research-informed “physics teaching” endeavor, in particular, central factors in teacher learning and in the interactions that are required for carrying out effective Research Practice Partnerships.
Front Matter
Authors: Taşar Mehmet Fatih , Heron Paula R. L. 
Published: March 2023

The International Handbook of Physics Education Research: Learning Physics covers the subject matter and cognitive aspects of physics learning. As the field of physics education research grows, it is increasingly difficult for newcomers to gain an appreciation of the major findings across all sub-domains, discern global themes, and recognize gaps in the literature. The International Handbook of Physics Education Research: Learning Physics incorporates the understanding of both physics and education concepts and provides an extensive review of the literature in a wide range of important topics.
The International Handbook of Physics Education Research: Learning Physics includes:Subject matter instruction and problem solving with specific topics including factors in student achievement in physics.Cognitive aspects to learning physics, including collaborative learning, higher order learning, and fostering critical thinking skills.Information about student interest, attitudes, motivation, values, beliefs, and opinions toward learning physics.
Readers will find this comprehensive treatment of the literature useful in understanding physics education research and extending to all the physical sciences including chemistry, mathematics, astronomy, and other related disciplines.
Introduction
Authors: Taşar Mehmet Fatih , Heron Paula R. L. 
Published: March 2023

The International Handbook of Physics Education Research: Special Topics covers the topics of equity and inclusion; history and philosophy of physics; textbooks; mathematics; research history, methodologies, and themes. As the field of physics education research grows, it is increasingly difficult for newcomers to gain an appreciation of the major findings across all sub-domains, discern global themes, and recognize gaps in the literature. The International Handbook of Physics Education Research: Special Topics incorporates the understanding of both physics and education concepts and provides an extensive review of the literature in a wide range of important topics.
The International Handbook of Physics Education Research: Special Topics includes:The history and philosophy of physics teaching, including a review of physics textbooks.Teaching mathematics for physics students.Methodologies in physics education research and the future of physics departments.
Readers will find this comprehensive treatment of the literature useful in understanding physics education research and extending to all the physical sciences including chemistry, mathematics, astronomy, and other related disciplines.
Front Matter
Authors: Taşar Mehmet Fatih , Heron Paula R. L. 
Published: March 2023

The International Handbook of Physics Education Research: Teaching Physics covers the topics of educational technologies, learning environments, teacher education, and assessment in relation to physics education. As the field of physics education research grows, it is increasingly difficult for newcomers to gain an appreciation of the major findings across all sub-domains, discern global themes, and recognize gaps in the literature. The current volume incorporates the understanding of both physics and education concepts and provides an extensive review the literature in a wide range of important topics.
The International Handbook of Physics Education Research: Teaching Physics includes:Various teaching perspectives including active learning, the modeling method, and teaching environments.Distance/online education, formative and summative assessment, and assessment in online education.Gender, race, and ethnicity equity.
Readers will find this comprehensive treatment of the literature useful in understanding physics education research and extending to all the physical sciences including chemistry, mathematics, astronomy, and other related disciplines.
Use of e-cigarettes among young queer men living in Aotearoa New Zealand
Authors: Bouttier-Esprit Thibaut , Dobson Rosie , Saxton Peter , McCool Judith 
Published: March 2023

Introduction Queer-identifying (non-heterosexual) men report higher rates of tobacco and e-cigarette use than the general population. The advent of e-cigarettes as a commercial product in Aotearoa New Zealand has been accompanied by aggressive marketing and a sharp uptake in use, especially among young people. Recent evidence suggests that e-cigarettes are widely used for purposes other than smoking cessation. Aim This study investigated how vaping is perceived and the role e-cigarettes play in the daily lives of young queer users. Methods Using focus groups with a semi-structured interview proforma, we interviewed twelve young queer men between July and August 2021. Interviews were queer-led, conducted via Zoom, and lasted up to 2 h. Interviews were audio-recorded and transcribed verbatim for subsequent inductive and thematic analysis. Results Of the twelve participants, 10 were daily users, and two described themselves as ‘social vapers’. We found strong evidence for minority and intra-minority stress as a driver to uptake and continued use of e-cigarettes. E-cigarettes were also used to navigate new social and cultural spaces and as currency for integration into various social milieux, including both mainstream and gay community spaces. There was little support for queer-targeted cessation initiatives. Discussion Vaping is highly socially acceptable within queer communities where it is a facilitator of social integration, managing stress and quitting tobacco.
Increasing the efficiency of drilling exploration wells with air bleeding based on the use of recovered heat of the compressor
Authors: Yuldoshov H , Dzhuraev R , Ganiev S , Khusanov Sh , An A 
Published: March 2023

Abstract
To date, the practice of drilling shows that the use of compressed air to clean the bottom of the cuttings is the most effective in difficult and unfavorable conditions for the use of drilling mud: when drilling in absorbing zones of flushing fluid, when it is impossible or difficult to supply water, when drilling in areas with negative ambient temperature. However, when drilling with bottomhole cleaning with air, the fuel and energy costs of drilling operations are significantly increased due to the use of compressor units, the drive energy costs of which are greater than pumps used in similar conditions. An analysis of the operation of mobile compressor units shows that a significant part of the energy losses falls on the internal combustion engine of the compressor drive, since not all of the combustible fuel is converted into useful power. Most of the thermal energy is removed from the engine to the cooling system and carried away with the exhaust gases. In this article, the energy losses of the internal combustion engine of the compressor are investigated and the possibility of increasing the energy efficiency due to the use of the recovered heat of the compressor drive and secondary energy resources is presented.