bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of anxiety and depression across childhood and adolescence on adverse outcomes in young adulthood: a UK birth cohort study
Authors: Morales-Muñoz I. , Mallikarjun P. , Chandan J. , Thayakaran R. , Upthegrove R. , Marwaha S. 
Published: August 2023

IntroductionLittle is still known about the long-term impact of childhood and adolescent persistent depression and anxiety on adulthood.ObjectivesTo investigate the impact of persistent anxiety, depression, and comorbid anxiety and depression across childhood and adolescence on the development of multiple adverse outcomes in young adulthood.Methods
This study used data from 8,122 participants in the ALSPAC cohort, in the UK. The Development and Wellbeing Assessment (DAWBA) was administered to capture child anxiety and depression symptomatology. We focused on the DAWBA generalized anxiety and mood subscales at 8, 10 and 13 years, and created a measure of comorbid anxiety and depression symptoms (i.e., anxiety + depression) at each time point. Further, a range of mental and physical health, and functional problems were assessed at 24 years. Latent Class Growth Analyses was used to detect trajectories of anxiety, depression and comorbid anxiety and depression, separately; and logistic regression to examine how persistent anxiety, depression or both associated with adverse outcomes at 24 years.ResultsAll three classes with persistent anxiety, depression or both associated with presenting any mental health and functional problem at 24 years. However, persistent high anxiety was not associated with any physical health problem at 24 years. Finally, high levels of comorbid anxiety and depression was the domain that exerted the greatest negative impact at 24 years.ConclusionsChildren and adolescents with comorbid anxiety and depressions are at highest risk for suffering from more adverse outcomes at 24 years, compared to those presenting anxiety and depression alone.Disclosure of InterestNone Declared
The impact of nonpsychotic postpartum psychiatric disorders (NPPDs) on offspring
Authors: Stojanov J. , Stanković M. , Stojanov A. 
Published: August 2023

IntroductionNon-psychotic postpartum psychiatric disorders (NPPDs) are among the most common underdiagnosed mental disorders with a preserved reality test after delivery.ObjectivesNPPDs have been shown to have an association with infant growth, attachment, sleep, temperament and ultimately offspring’s emotional, behavioural, cognitive and social development.MethodsMost prevalent NPPDs are postpartum mood and anxiety disorders, as well as obsessive–compulsive disorder, post-traumatic stress disorder and eating disorders.ResultsThe high methodological quality of the reviewed studies strengths the association between NPPDs and different disorders in the neurodevelopmental period with a negligible impact on mental status in adolescence and adulthood. NPPDs showed an effect on offspring’s emotional, behavioural, cognitive and social development, due to common developmental mechanisms.ConclusionsTimely accurate identifying and treating NPPDs, by using NPPDs symptoms screening tools could reduce the incidence of mental disorders in offspring. Although neurodevelopmental disorders and mental disorders related to pregnancy as separate diagnostic categories have been insufficiently researched, the potential impact of postpartum mental disorders on children’s development is an extremely unexplored field that should be focused on in further scientific research.Disclosure of InterestNone Declared
Comments on the position UEMS paper “Maintaining Human Rights and recovery principles when Coercive Practices are considered”
Authors: Ivezic S. S. 
Published: August 2023

AbstractProf. dr. sc. Slađana Štrkalj Ivezić, psychiatrist, University psychiatric hospital Vrapče, CroatiaThe aim is to present the importance of educating psychiatrists to acquire competencies relate to knowledge, attitudes and behavior in holistic understanding of patients, implementation of principles of recovery and respect for human rights and use of alternative interventions to coercion in order to eliminate or reduce coercive practice such as involuntary hospitalizations and coercive measures. All the necessary competences such as clinical assessment, skills to form therapeutical relationship and application of evidence base interventions that can prevent or significantly reduce the use of coercive measures: de-escalation; availability of a comfort room with sensory modulation; a trained response team; joint crisis intervention, advance directives and successful multimodal strategies will be presented including the elimination of potential environmental triggers of aggression in the hospital setting. The training and education of psychiatrists on human rights, recovery and alternatives to coercive practice can abolish or significantly reduce coercion.Disclosure of InterestNone Declared
Parents of children who are victims of trauma, allies or adversaries?
Authors: Ben Youssef H. , Bourgou S. , Gadhoum R. , Rezgui H. , Ben Hamouda A. , Daoud M. , Charfi F. , Belhaj A. 
Published: August 2023

Introductiontrauma affects not the child but the whole family. how would the parents’ reaction to trauma influence the child’s resilience capacities?Objectivesstudy the mental health status of parents of children consulting the trauma and resilience unit.MethodsDescriptive and retrospective study of 20 consultants in the trauma and resilience unit at Mongi Slim hospital between January and April 2022. The evaluation of depressive symptoms in children was made by Children&#39;s Depression Inventory (CDI). The Hamilton Depression and Anxiety Scales were used to assess anxiety and depressive symptomatology in the parents of the consultants.ResultsThe mean age of the children was 10.46±3.24.The traumatic event was related to an assault in 75% of cases, 45% of which were intrafamilial, road accident and death of a relative in 10% respectively, 5% domestic violence.Five consultants had a CDI score ≥8 and 15 had a score >10. Only parents of children with a CDI score>19 had moderate to severe symptoms according to hamilton scales.The diagnosis of adjustment disorder was made in 45% of cases, post-traumatic stress disorder 20%, acute stress disorder 10% other 15%ConclusionsThe parents’ reaction to the tragedy would play a modulating role on the children’s resilience capacities. less anxious and depressed parents would help their child build his/her coping mecanisms.Disclosure of InterestNone Declared
The metabolic syndrom and the prescription of psychotropic drugs in children and adolescents: three clinical cases
Authors: Elmaataoui Z. , Belhadga H. , Kisra H. 
Published: August 2023

IntroductionAntipsychotics have shown their interest in several pathologies of the child and the adolescent. However, in this vulnerable population, they are not without adverse effects. Depending on the type of molecule used, classical neuroleptics or second generation antipsychotics, but also within these own classes, the profile of tolerance and adverse effects differs. In this sense, children treated with psychotropic drugs have a higher risk of developing metabolic syndrome compared to children who do not take this treatment.ObjectivesThe aim of this work is to discuss the metabolic syndrome in children treated with psychotropic drugs and this through three clinical vignettes.Methodswe conducted our study through an analysis of three clinical casesResultsIt is about three children followed in the service of child psychiatry of the hospital Ar-razi of salé, aged respectively 11, 13 and 14 years, these children were put under psychotropic drugs for various mental disorders and developed during the evolution of metabolic side effects in particular a dyslipidemia, a diabetes of type 2 revealed by a diabetic ketoacidosis and a hyperprolactinemia.ConclusionsSystematic monitoring and preventive programs targeting weight gain and metabolic side effects should be an integral part of the overall management of adolescents on psychotropic medications.Disclosure of InterestNone Declared
Definitions and scope of the mental health burden of global climate change
Authors: Vergunst F. , Williamson R. , Mazzazza A. , Berry H. , Olff M. 
Published: August 2023

IntroductionClimate change is increasing the frequency of extreme weather events – such as heatwaves, droughts, floods, and wildfires – and undermining the mental health and wellbeing of global populations, but the dimensions and scope of this burden remain under-studied.ObjectivesTo identify the distinct but overlapping mental health domains that are being impacted by climate change-related stressors and how these domains relate to and interact with one another.MethodsA narrative synthesis of conceptual and empirical studies of climate change and mental health.ResultsWe find strong empirical evidence that climate change is already harming mental health across multiple mental health domains, including through increased rates of psychiatric disorders (e.g., PTSD, depression, anxiety), sub-clinical psychological distress, harmful substance use, self-harm/suicidal behaviors, and worry about the observed and anticipated impacts of climate change. Most of the mental health burden is likely to occur in the form of sub-clinical symptoms, including lowered resilience and subjective well-being, while negative psychological states (e.g., eco-anxiety) are likely to constitute a smaller proportion of the overall burden. We argue that the mental health burden can be helpfully conceptualised within a dual-continuum model that considers the presence/absence of psychiatric diagnosis on the one hand, and high/low psychosocial wellbeing on the other.Image:ConclusionsClimate change is already harming the mental health of global populations across multiple functional domains. Defining and tracking the scope of this growing burden is essential so that effective preventive and adaptive action can be taken.Disclosure of InterestNone Declared
depressive disorder and herpes zoster oticus: a case report
Authors: Chebli H. , FARH A. , belbachir S. , ouanass A. 
Published: August 2023

IntroductionThe herpes zoster oticus results from the reactivation of the varicella zoster virus, a DNA virus of the Herpesviridae family with strictly human-to-human contamination, affecting the geniculate ganglion of the facial nerve. The manifestations of shingles and post-herpes signs are associated with psychiatric manifestations such as anxiety, insomnia and depressive disorder. Shingles and depressive disorder share common features, such as decreased cellular immunity and a high prevalence in the elderlyObjectivesIs there a correlation between the intensity of depression and the comorbidity of herpes zoster and depression? Is there an explanation for this association? Can adequate therapy of the infection prevent the occurrence of the depressive disorder? Does the existence of this comorbidity affect the response to antidepressants?Methodscase report and litteratureResultscase reportConclusionsWe will try to answer these questions in this work while illustrating by the case of a patient having been touched by this comorbidity and while being based on what was published in literature.Disclosure of InterestNone Declared
“Alcohol use and suicide in Lithuania: proximity shouting out loud”
Authors: Jokūbonis D. 
Published: August 2023

AbstractIn the recent past, the standardized suicide mortality rate (SMR) in Lithuania was more than double the global SMR and nearly one and a half higher than in the EU. Herewith Lithuania has high male-to-female SMR ratios e.g., at 7.1 in 2016. Autopsy studies in Lithuania revealed that approximately two thirds of men and one third of women who died by suicide had a blood alcohol con-centration level above 0.04 g/dL. Although suicide is a complex phenomenon, heavy alcohol use has been considered as it’s important risk factor though the relationship was never systematically studied before in Lithuania. Experts have suggested that gender differences in excessive alcohol consumption can explain the gender disparity in suicide mortality and linked tackling the harmful use of alcohol as an opportunity for suicide prevention. Alcohol control policies may cause immediate effect on excessive alcohol consumption at both the population and individual-level and may be capable of impacting suicide mortality rates by altering alcohol use patterns at both domains. Implementation of alcohol taxation policy in Lithuania provided an opportunity to evaluate it‘s impact on suicide mortality in a country comparable to other high income countries with a comparable health care and medical education systems.Disclosure of InterestNone Declared
Infliximab induced severe depression and suicidal thoughts in patient with bipolar disorder
Authors: Ulual P. , Burhan H. S. , Güçlü O. 
Published: August 2023

IntroductionInfliximab is a tumor necrosis factor-alpha (TNF-α) inhibitor commonly used in the treatment of autoimmune disorders such as rheumatoid arthritis and ankylosing spondylitis. An increased risk of opportunistic infections, malignancy, and neurodegenerative diseases have been widely documented as adverse effects of IFX therapy. Few reports exist serving the notice of new-onset psychiatric symptoms linked to IFX treatment, such as suicidal behaviors in adults and elderly patients, as well as psychosis in an adolescent. Psychiatric side effects while under IFX treatment are reported to be rare.ObjectivesHere, we present a case of a female with bipolar disorder who developed a long-standing depressive episode with suicidal thoughts after her fourth infusion of infliximab for her ankylosing spondylitisMethodsRetrospective life chart was created, including infliximab infusion.Montgomery Asberg Depression Scale was applied at time of hospitalisation and discharge.The Naranjo Adverse Drug Reaction Probability Scale was applied.ResultsA 55 year old female with ankylosing spondylitis and bipolar disorder was treated with IFX for 8 months. During this period, a total of 4 infusions were administered and AS symptoms were well responding to the treatment. Patient describes the onset of depressive symptoms such as anhedonia and insomnia after the infusion of third IFX infusion, gradually progressing to loss of function and suicidal thoughts and hospitalization in a psychiatry clinic.The patient had a history of bipolar disorder for 10 years with recurrent manic and depressive episodes, 4 hospitalisations and 1 cure of ECT.
Patient was on sertraline, maprotiline and diazepam at the time of hospitalization. We started treatment with aripiprazole, quetiapine and valproate, followed for 4 weeks as an inpatient, consulted with rheumatology treatment options and neurology for demyelinating disorders, no pathology was discovered. Rheumatology suggested the continuation of IFX infusion under psychiatric control. Fifth dose of IFX infusion was administered and patient was discharged after euthymic mood was established and insomnia and suicidal thoughts were deteriorated. Upon follow up, depressive symptoms recurred and lamotrigine was added for augmentation.Image:ConclusionsAlthough there is very scarce evidence that IFX causes psychiatric symptoms, there are few clinical trials too, showing evidence that TNF-alpha inhibitors may improve depressive symptoms. While we need more information and evidence to support the ideas of TNF alpha inhibitors effects on human neuropsychology, it is of great importance for especially patients with psychiatric history to be closely watched while administering the product, at least to minimize unintended adverse events.Disclosure of InterestNone Declared
Varenicline induced auditory hallucinations in a young female with bipolar disorder: a case report
Authors: Bhanot S. , Tsang V. W. L. , Jia L. 
Published: August 2023

IntroductionCreating appropriate and sustainable treatment plans for patients with concurrent disorders presents a challenge to psychiatrists and addiction medicine specialists alike. Although varenicline has been found to be one of the most effective medications for smoking cessation and abstinence, caution is needed when starting patients on this medication. In this case, a young female provisionally diagnosed with bipolar I disorder was hospitalized for a manic episode in the context of substance abuse and medical noncompliance. She also endorsed a long history of smoking, alcohol, cocaine, cannabis and ketamine use. In addition to being stabilized for bipolar disorder, the patient was started on varenicline for smoking cessation on Day 14 of admission.ObjectivesThis case report highlights the potential risk of de-stabilization in a vulnerable youth with newly diagnosed bipolar I disorder and precarious social circumstances, in attempts to further concurrent approaches to psychiatric care.MethodsIn addition to qualitative observations, the main objective exam used to track patient progress through the duration of her hospitalization was the mental status exam (MSE). This is standard practice for psychiatric care and qualitatively assessed factors related to a patient’s behavioral and cognitive functioning. Important factors assessed for this patient include appearance and behavior, speech, affect and mood, thought form, thought content, perceptual abnormalities, insight and cognition.ResultsPerceptual abnormalities, including auditory hallucinations, were not recorded at admission and the patient’s symptoms of mania were resolving clinically on Day 18. Two days after starting varenicline, the patient developed auditory hallucinations, paranoia and referential beliefs. However, her insight was intact, and she had minimal thought-form disorganization. The patient also reported hearing auditory hallucinations of a derogatory nature, with her mood appearing more distressed during varenicline use. Symptoms were found to be resolved shortly after the discontinuation of varenicline on Day 18 and the patient appeared to be less distressed on following days. In this case, these symptoms were not in keeping with her bipolar diagnosis and thought to be secondary to varenicline after the consideration of potential alternative contributors.ConclusionsThe occurrence of side effects as a result of varenicline use in patients with diagnosed mental health conditions is rare and underlying psychiatric illness is not labeled as an absolute contraindication in the prescription of varenicline. However, it is important to advocate for increased guidance and research on the treatment of substance use disorders in patients with bipolar I disorder.Disclosure of InterestNone Declared
Online pornography use during the COVID-19 pandemic: a review
Authors: Portela C. , Dionísio R. , Sousa S. M. , Gonçalves M. 
Published: August 2023

IntroductionThe Coronavirus (COVID-19) pandemic and the regulations enforced to control it caused significant alterations in daily routines worldwide. Lockdowns, remote working and schooling favoured virtual interactions and increased “free-time”, with the internet posing as a preferential means of distraction. Statistics from pornographic websites have shown a rise in traffic during lockdown periods, with problematic use of pornography (POPU) emerging as a potential mental health concern.ObjectivesThe authors aim to summarize current knowledge on the effects of the COVID-19 pandemic on online pornography use.MethodsNarrative review of articles referenced on PubMed and Google Scholar.ResultsThe increased exposure to the internet during the pandemic, combined with psychosocial factors such as social isolation, diminished physical contact and intimacy may have contributed to the reported surge in online pornography use. Other associated factors include emotional distress and less availability of other addictive substances and behaviours during confinement periods. Besides the spike in pornography consumption, other aspects were also affected, such as time of usage, search keywords and type of content, with an increase in engagement in illegal pornography. In susceptible individuals, these circumstances may lead to the development of POPU, characterized by impaired control, excessive time spent and perceived negative consequences. Currently, there is a lack of consensual diagnostic criteria for POPU, hindering the detection of these patients and timely management.ConclusionsBehavioural addictions are an emerging mental health problem, particularly the ones related to internet use. In the aftermath of the pandemic, considering the reported rise in online pornography use, an increase in POPU prevalence is expected. Therefore, more accurate and consensual diagnostic criteria are required, as well as a greater amount of evidence on the treatment of this disorder, in order to improve the approach to these patients.Disclosure of InterestNone Declared
The impact of SARS-Cov-2 pandemic on mental health in medical staff
Authors: Bacaiteanu C.-B. , Bucatos B.-O. , Romosan A. , Bondrescu M. , Daescu A.-M. C. , Romosan R. , Papava I. , Laza R. , Dehelean L. 
Published: August 2023

IntroductionSARS-Cov-2 pandemic resulted in a great amount of mental health suffering both in patients, families and medical staff.ObjectivesTo assess the personal impact of SARS-Cov-2 management in hospital health care staff.MethodsThe study included 300 participants, comprising medical staff, 150 of which directly treated patients with SARS-Cov-2 infection, whilst the rest did not. Participants were asked to fill in online self-assessment scales: PSS-10 (Perceived Stress Scale), BAI (Beck Anxiety Inventory), BDI (Beck Depression Inventory), and SSOSH (Self Stigma of Seeking Psychology Help Scale). The data were collected at the end of 2021 during the COVID-19 pandemic with the Omicron variant.Results238 (79.3%) women and 62 (20.7%) men responded to the online assessment. Participants working in COVID wards had higher scores for anxiety and depression (χ²=12.21, p=0.007). The intensity of depression and anxiety (BDI / BAI) depends on the professional degree (higher in senior specialists and specialists than in nurses and residents), working in shifts (χ²=8.77, p=0.01) and recent contact with patients infected with SARS-Cov-2 (χ²=76.10, p<0.0001). Regarding PSS-10 total scores, participants that had contact with 1-10 SARS-Cov-2 patients during the past month had significantly higher scores than those who did not. SSOSH showed that participants who had more than 5 on-calls per month had significantly higher scores than the participants who had one on-call per month (p=0.008). Logistical regression showed that participants who had higher BDI scores had a probability of 136.67 times higher (95% CI [16.42; 1137.53]) to present high stress levels.ConclusionsRespondents who had higher scores in the BDI (and not other assessment scales) had by far the highest probability of developing high stress levels.Disclosure of InterestNone Declared