bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report
Authors: Abshirini Hassan , Heidari Mahsa , Fahimi Ali , Ghorbani Parastoo , Ghadirzadeh Erfan , Shafiei Sasan 
Published: June 2023

Key Clinical MessageHyperparathyroidism is a common endocrine disorder, which must be suspected in patients presenting with fatigue, history of pathologic fracture and the diagnosis can be confirmed by elevated calcium and PTH levels, and the preferred treatment option.AbstractPrimary hyperparathyroidism (PHPT), a common endocrine condition, with elevated parathormone production causes increased blood calcium levels. Parathyroid adenomas cause the majority of PHPT cases. Significant hypercalcemia can result from giant parathyroid adenomas. A calcium crisis may not always arise in these individuals, despite enormous parathyroid adenomas and high parathyroid hormone levels, and the masses may first be mistaken for a thyroid mass. In this article, we discuss the case of a 57‐year‐old Iranian man who suffered from PHPT due to a massive parathyroid adenoma and had a history of extreme fatigue and several traumatic fractures. As specialists, we should have a strong clinical suspicion of giant parathyroid adenoma as reason of hyperparathyroidism. In patients with multiple bone problems such as pain and multiple pathological fractures and elevated levels of calcium and PTH, the diagnosis of GPA must be considered and their preferred treatment is surgery.
Slipped capital femoral epiphysis as primary presentation in an adolescent with primary hyperparathyroidism due to ectopic mediastinal parathyroid adenoma
Authors: Badhe Padma Vikram , Patil Sanika , Vikram Reddy G. , Sheshadri Harini , Jain Sanjay , Nikumbh Tejas 
Published: June 2023

Key Clinical MessageEctopic mediastinal parathyroid adenoma causes primary hyperparathyroidism presenting as hypercalcemia. When children with hypercalcemia present with slipped capital femoral epiphysis, a detailed evaluation for hypercalcemia must be done before surgery.AbstractThe association between slipped capital femoral epiphysis (SCFE) and hyperparathyroidism has been reported and is rare. Each is known to affect different age groups. We report a case of a 13‐year‐old boy with SCFE and primary HPT leading to hypercalcemia and skeletal deformities.
Neurosarcoidosis in an adult man with a family history of MS: A case report
Authors: Mirmosayyeb Omid , Mohammadzamani Mahtab , Bagherieh Sara , Ghaffary Elham Moases , Azimi Elham Sadat , Shaygannejad Aysa , Shaygannejad Vahid 
Published: June 2023

Key clinical messageAccording to this report, a biopsy revealed a diagnosis of neurosarcoidosis in a patient with a history of MS. The development of the disease can be slowed down by early diagnosis and appropriate treatment.AbstractNeurosarcoidosis is a rare type of sarcoidosis that affects the central nervous system (CNS). Herein, we present a case of neurosarcoidosis with a history of multiple sclerosis (MS). Based on the pathological findings of the biopsy, a diagnosis of neurosarcoidosis was established. The administration of appropriate treatment at an early stage can assist in decelerating its progression.
A rare presentation of malignant mesothelioma of the tunica vaginalis managed with immunotherapy and review of the literature
Authors: Mishra Kritika , Siddiquee Shihab , Mislang Anna Rachelle 
Published: June 2023

Key Clinical MessageWe describe the first case in literature of malignant mesothelioma of the tunica vaginalis that has shown partial response to systemic immunotherapy (ipilimumab‐nivolumab) post orchiectomy, warranting further investigation in a trial setting.AbstractWe present a case report of an 80‐year‐old ex‐smoker with a rare diagnosis of metastatic mesothelioma of the tunica vaginalis, managed with immunotherapy. The patient, with no known history of asbestos exposure, presented with a left scrotal mass and pain. Scrotal ultrasound confirmed a large paratesticular mass, and computed tomography (CT) of the chest, abdomen, and pelvis revealed a bilobed mass in the left scrotal compartment without associated inguinal or abdominopelvic lymphadenopathy, and an indeterminate, subcentimeter, bi‐basal subpleural nodules. He underwent a left orchiectomy, and histopathology confirmed the diagnosis of a paratesticular mesothelioma. Postoperatively, the patient had a positron emission tomography (PET) scan showing a new right pleural effusion as well as increasing size of the lobar and pleural nodules bilaterally, all metabolically active and suggestive of progressive metastatic disease. The patient was commenced on ipilimumab and nivolumab immunotherapy, a regimen indicated for malignant pleural mesothelioma; however, the efficacy on paratesticular mesothelioma is not known. After 6 months of treatment, the patient demonstrated a partial response to immunotherapy, with a reduction in the size of known pleural nodules and effusion.Literature review suggests that diagnosis requires a high index of suspicion and patients commonly have metastatic disease at the time of diagnosis. Orchiectomy is a common management modality. However, the role, regimen, and benefits of systemic therapy are unclear, warranting further studies investigating management strategies.
Enhanced Brønsted Acidity and Hydrogenating Sites Generated on MoO3 during Acetone Hydrodeoxygenation
Authors: Báfero Gabriel B. , Strapasson Guilherme B. , Leite Davi S. , Zanchet Daniela 
Published: June 2023

AbstractMetal oxides have attracted attention as catalysts for various reduction and oxidation reactions due to their abundance, inexpensiveness, and the possibility of combining different catalytic sites (e. g., acid‐base, redox, and oxygen vacancy sites). Previous results have demonstrated that metal oxides are promising candidates for the hydrodeoxygenation (HDO) reaction, one of the processes that aim to upgrade biomass‐derived products by reducing their oxygen content. In this work, molybdenum oxide (MoO3) was subjected to the acetone HDO reaction leading to new insights concerning the generation of molybdenum oxycarbides (MoOxCy) on stream and their catalytic properties. The characteristics of the MoOxCy phase depended on the temperature and time on stream, affecting the balance of the different catalytic sites and the final products’ distribution. The intrinsic correlation between the active sites – mainly Brønsted/Lewis acid sites (AS) and hydrogenation/hydrogenolysis sites (HS) – and the reaction pathways was discussed in detail.
Mechanism of RBBP8‐mediated homologous recombination repair in gastric cancer synthetic lethal
Authors: Yu Yang , Wang Shuxia , Yin Yanhua , Wang Guangsheng 
Published: June 2023

AbstractBackgroundIt is of great clinical significance to further explore new strategies and potential combined therapeutic targets for gastric cancer. This study aimed to investigate the synthetic lethal effect of RBBP8 molecular intervention combined with a poly ADP ribose polymerase (PARP) inhibitor in non‐BRCA mutant gastric cancer and clarify the mechanism by which RBBP8 regulates homologous recombination repair.MethodsThe role of RBBP8 in DNA damage repair was observed using bioinformatic analysis, western blot analysis, and immunofluorescence. The synthetic lethal effect was verified using 3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazolium, inner salt (MTS)and flow cytometry apoptosis experiments.ResultsAmong the patients with gastric cancer treated with chemotherapy, the prognosis of patients with high RBBP8 expression levels was worse (homologous recombination [HR] = 1.54, p = 0.028). RBBP8 knockdown induced DNA damage and had a synergistic effect with PARP inhibitor treatment on cell viability inhibition and cell apoptosis in AGS (generic code for human gastric adenocarcinoma cells) (t = 11.154, p < 0.001) and N87 (t = 6.362, p < 0.001) cells. RBBP8 knockdown inhibited RAD51 activation and DNA terminal excision in homologous recombination repair.ConclusionRBBP8 is involved in homologous recombination repair, and molecular intervention into RBBP8 could achieve a synthetic lethal effect with PARP inhibitor treatment in gastric cancer cells.
Expanding the Substrate Scope of Acyltransferase LovD9 for the Biosynthesis of Statin Analogues
Authors: García‐Marquina Guillermo , Núñez‐Franco Reyes , Grajales‐Hernández Daniel , Jiménez‐Osés Gonzalo , López‐Gallego Fernando 
Published: June 2023

AbstractInvited for the cover of this issue are the groups of Gonzalo Jiménez‐Osés and Fernando López‐Gallego at CIC bioGUNE and CIC biomaGUNE, respectively. The image depicts the substrate scope of an engineered acyl transferases for the synthesis of statin derivatives. Read the full text of the article at 10.1002/chem.202300911.
The impact of institutional interactions on cluster response to innovation: The case of Montreal and neural machine translation
Authors: Girard Meaghan J. , Turkina Ekaterina 
Published: June 2023

AbstractDespite the importance of institutions in the cluster literature, scholarship has struggled with its conceptualization of institutions, resulting in an incomplete portrait of diverse phenomena. In response, we crystallize a hybrid stream of institutionalism that has emerged in the economic geography literature and propose the construct of institutional interactions to provide structural and relational insight into cluster‐wide resistance to innovation. By pairing network analysis with a genealogical study of the Montreal translation cluster, we isolate the impact of institutional interactions and find preliminary support for the redundancies created by institutional brokers and institutional network characteristics. We demonstrate how to use the construct of institutional interactions to diagnose constraints to innovation in an institutional environment.
Propagating input uncertainties into parameter uncertainties and model prediction uncertainties—A review
Authors: Abdi Kaveh , Celse Benoit , McAuley Kim 
Published: June 2023

AbstractA review of uncertainty quantification techniques is provided for a variety of situations involving uncertainties in model inputs (independent variables). The situations of interest are divided into three categories: (i) when model prediction uncertainties are quantified based on uncertainties in uncertain inputs, (ii) when parameter estimate uncertainties are calculated by propagation of uncertainties from measured inputs and outputs, and (iii) when model prediction uncertainties are quantified based on corresponding uncertainties in measured inputs and uncertain parameter estimates. For all three situations, linearization‐based and Monte Carlo‐based techniques are reviewed and details for their corresponding algorithms are presented. Recommendations are provided on which uncertainty quantification techniques are best for different types of chemical engineering models based on the amount of input uncertainty and nonlinearity over the range of plausible input and parameter values.
Monitoring Molecular Dynamics withSingle‐MoleculeElectronic Devices and Fluorescence Techniques†
Authors: Yang Lan , Zhang Zhizhuo , Zhao Cong , Huo Yani , Zhang Enyu , He Suhang , Jia Chuancheng , Guo Xuefeng 
Published: June 2023

Comprehensive SummaryMonitoring the dynamics of a single molecule provides unique insights into the fundamental physical and chemical properties of individual molecules. Over the past few decades, various approaches have been developed to enable the real‐time and high‐resolution detection at the single‐molecule level. Among them, electrical and optical methods are the most promising tools, for the reason that electrical detection offers high resolution while optical technology provides non‐invasive, targeted measurement with the added benefit of visualization. In this review, we summarized the current state‐of‐the‐art electrical and optical techniques for single‐molecule measurement and discussed their applications in detecting dynamic events such as conformational isomerizations, intermolecular interactions, chemical reactions, and biomolecular activities. In addition, we discussed the challenges and opportunities in this area and proposed possible directions for future development.
Rongalite as a Versatile Reagent in Organic Synthesis†
Authors: Wang Huai‐Yu , Chen Xiang‐Long , Wu Yan‐Dong , Wu An‐Xin 
Published: June 2023

Comprehensive SummaryThis review provides a comprehensive summary of progress to date in the utilization of rongalite as a versatile reagent in organic synthesis, with a focus on recent researches. The contents have been organized according to the functions exhibited by rongalite. Reaction mechanisms are provided, demonstrating the multifaceted roles of this compound in various transformations, including as a sulfone, C1 or masked proton source and as a single electron donor or reducing agent.
PROTOCOL: Value chain interventions for improving women's economic empowerment: A mixed‐method systematic review
Authors: Malhotra Suchi Kapoor , Saran Ashrita , Singh Sabina , Mantri Swati , Gupta Neha , Bhandari Ratika , White Howard , Puskur Ranjitha , Young Sarah , Waddington Hugh , Masset Edoardo 
Published: June 2023

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows: The primary objective of this review is to understand as well as evaluate what approaches, strategies or interventions focused on women's engagement in agricultural value chains and markets that have led to women's economic empowerment in low‐and‐middle‐income countries. The secondary objective of this review is to examine in which contexts are these approaches effective (or ineffective)? What are the contextual barriers and facilitators, determining the participation of women in, and benefits from, engagement in the value chain in low‐and middle‐income countries programme effectiveness. Finally, this review aims to refine the theory of change that describes how value chain interventions lead to women's economic empowerment using evidence drawn from both rigorous quantitative impact evaluation studies and qualitative studies.
An overview of the electrocardiographic monitoring devices in sports cardiology: Between present and future
Authors: Pingitore Annachiara , Peruzzi Mariangela , Clarich Sofia Calaciura , Palamà Zefferino , Sciarra Luigi , Cavarretta Elena 
Published: June 2023

AbstractBackgroundAthletes represent a mainly healthy population, which however could be considered at risk of major arrhythmic events, especially in case of undiagnosed cardiomyopathies. For this reason, the periodical sports medicine examination and the electrocardiography are essential tools in the cardiovascular screening, even though they do not always succeed in identifying rhythm disturbances, particularly when asymptomatic or rarely symptomatic.HypothesisProlonged cardiac monitoring often enables clinicians to stratify the arrhythmic risk and reach the diagnosis. The technological progress of the last decades has produced an always‐increasing number of heart rhythm monitoring devices, starting from the 24‐hour electrocardiogram Holter monitoring and ending with the wide world of wearable devices.MethodsIn the literature, the extreme utility of this equipment in the patients affected by cardiovascular diseases and in the general population is well established. On the contrary, athletes‐based randomized trials or large‐scale epidemiological studies targeting the frequency of cardiac symptoms and the use of cardiac monitoring are missing, while an ever‐growing number of case series and small observational studies are flourishing in recent years.ResultsThe present review showcases the available electrocardiographic monitoring options, principally in the medical setting, listing their characteristics, their indications, their supporting evidence, and their general pros and cons.ConclusionsThe ultimate goal of this review is guiding physicians through the wide variety of heart rhythm monitoring options in the specific subfield of sports cardiology, when an arrhythmia is suspected in an athlete, to tailor the diagnostic process and favor the best diagnostic accuracy.
Design and Optimization of C6H5NO2‐Core Photonic Crystal Fibers for Broadband Supercontinuum Generation with Low Peak Power
Authors: Dang Van Trong , Chu Van Lanh 
Published: June 2023

AbstractThis study presents a new square‐lattice photonic crystal fiber (PCF) with a nitrobenzene core. Considering the non‐uniformity of the air hole diameter, this new design allows the characteristic quantities to be optimized simultaneously to ensure near‐zero dispersion, a small effective mode area, and low loss for efficient spectral broadening. The spectrum broadens significantly at peak powers many times lower than in previous studies. Based on the obtained results, two optimal PCFs are proposed and validated in detail for supercontinuum generation (SCG). The first fiber #F1 operates in an all‐normal dispersion regime with a pump wavelength of 1.3 µm.It produces a spectral supecontinuum (SC) from 0.726 to 1.649 µm with a pulse duration of 90 fs and a peak power of 133 W. Meanwhile, the second fiber #F2 operates in anomalous dispersion regime with a pump wavelength of 1.61 µm. With a low peak power of 300 W and a pulse duration of 150 fs, the fiber #F2 provides SC generation with bandwidth from 0.805 µm to 3.970 µm. The proposed fibers are suitable for all‐fiber SC light sources, respectively, and may lead to new low‐cost all‐fiber optical systems.
Accelerated leaf appearance and flowering in maize after four decades of commercial breeding
Authors: dos Santos Caio L. , Miguez Fernando E. , King Kyle A. , Ruiz Alejo , Sciarresi Cintia , Baum Mitchell E. , Danalatos Gerasimos J. N. , Stallman Mickala , Wiley Emily , Pico Lia Olmedo , Thies August , Puntel Laila A. , Topp Christopher N. , Trifunovic Slobodan , Eudy Douglas , Mensah Clarice , Edwards Jode W. , Schnable Patrick S. , Lamkey Kendall R. , Vyn Tony J. , Archontoulis Sotirios V. 
Published: June 2023

AbstractMaize breeding programs have indirectly altered many plant traits; however, our knowledge of some important phenological traits remains unexplored. One such trait is leaf appearance rate, which is crucial for predicting maize development. We studied 40 short‐season (103‐day) and 38 long‐season (111‐day) hybrids released from 1980 to 2020 by Bayer Crop Science. Measurements included weekly counting of collared leaves across 13 experiments in the US Corn Belt. The progression of leaf number was expressed as a function of thermal time and described with a trilinear model. Results indicated that new 111‐day hybrids produce leaves faster than old hybrids throughout the vegetative phase (7.4% and 3.1% faster before and after the ninth leaf stage, respectively), whereas new 103‐day hybrids produce leaves faster only after the ninth leaf stage (9.4%). Thermal time to silking and anthesis decreased by about 1 and 0.56°C day year−1, respectively. Our data revealed that silking and anthesis can precede the final collared leaf by 96°C day (3.3 days under optimal conditions), which indicates an overlap between vegetative and reproductive phases. We concluded that maize breeding has indirectly altered the rate of vegetative development of maize hybrids without affecting the final leaf number. Present results expand our knowledge base on the genotypic variability in maize development traits, which can improve empirical and process‐based models used for crop stage and yield prediction.
How to combine ESG scores? A proposal based on credit rating prediction
Authors: Agosto Arianna , Giudici Paolo , Tanda Alessandra 
Published: June 2023

AbstractThe diffusion of Environmental, Social and Governance (ESG) metrics is increasingly affecting corporates behaviour and their ability to attract investors. Corporate ESG practices are nowadays considered as a key element in evaluating creditworthiness and the cost of capital, to direct funds to the best‐performing companies that limit the harmful impact on the planet and the societies. Due to this increased interest in ESG by companies, investors and policymakers, a high number of ESG scores and metrics have been developed, each with different methodologies and scopes. Because of this variety, it could be therefore challenging for investors to understand and compare ESG measures. In this paper, we address this issue by proposing a method to combine the information provided by different ESG scores into a single aggregate measure of company sustainability and link this combined score to the credit rating of companies. The proposed methodology can help investors to improve their investment decisions by combining more diverse information on company sustainability as a driver of companies' credit rating, thereby reducing information asymmetries.
Multi‐port single‐phase inverter considering battery‐alone mode for stand‐alone applications
Authors: Ahmadian Sina , Hemmati Siroos , Abbasi Vahid 
Published: June 2023

SummaryThis paper presents a new single‐phase multi‐port DC–AC converter with high voltage gain in low duty cycle. The operation of the proposed converter consists of four modes, especially battery‐alone mode, which makes it appropriate for stand‐alone renewable applications. Using a suitable boosting method, this converter can achieve high voltage gain in all modes. The high gain performance of the converter occurs at both low shoot‐through duty cycle and high modulation index. Therefore, the output voltage and current harmonics as well as the filter size are reduced. In addition, the converter transfers the power with a continuous current through its input ports and has a common ground between the input sources and the inverter bridge. The positive features of this converter are the result of the appropriate design and localization of the bidirectional port that connects the battery to the converter. The proposed configuration includes an impedance network that protects the converter in the shoot‐through states and takes the advantage of the shoot through in its boosting performance. Another advantage of the proposed converter is that the voltage stress on the power switches on the DC side is considerably low. In order to validate the feasibility and effectiveness of the converter, a prototype rated at 110 V is prepared and tested.