bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability of assessing morphologic features with prognostic significance in cytology specimens of epithelioid diffuse pleural mesothelioma and implications for cytopathology reporting
Authors: Li Yan , Salama Abeer M. , Baine Marina K. , Bodd Francis M. , Offin Michael D. , Rekhtman Natasha , Zauderer Marjorie G. , Travis William D. , Adusumilli Prasad S. , Sauter Jennifer L. 
Published: May 2023

AbstractBackgroundThe World Health Organization incorporates morphologic features with prognostic significance in the 2021 classification of epithelioid diffuse pleural mesothelioma (E‐DPM). Although cytology specimens are often the first and occasionally the only specimen available for patients with DPM, these features have not yet been investigated in cytology.MethodsNuclear atypia, pleomorphic features, necrosis, and architectural patterns were retrospectively assessed in 35 paired cytology and concurrent/consecutive surgical pathology specimens of E‐DPM. Agreement between pairs was determined via unweighted κ scores. Discordant cases were re‐reviewed to determine the reasons for disagreement.ResultsInterpretation of nuclear atypia in cytology was concordant with histology in all cases (κ = 1.000; p < .001). The presence of pleomorphic features and necrosis was concordant in 97.1% (κ = 0.842; p < .001) and 85.7% (κ = 0.481; p = .001) of paired cases, respectively. Assessment of architectural patterns in cytology showed only slight agreement with histology (κ = 0.127; p = .037). In cytology cases (n = 23) with cell block material available, assessment of nuclear atypia and the presence of pleomorphic features showed perfect agreement (κ = 1.000; p < .001, each), the presence of necrosis showed moderate agreement (κ = 0.465; p = .008), and assessment of architectural patterns showed slight agreement (κ = 0.162; p = .15) in paired specimens. Most disagreements were due to sampling differences between cytology and histology specimens.ConclusionsAlthough complete nuclear grading of E‐DPM is not possible given the unreliability of mitotic counts in cytology, assessment of nuclear atypia in cytology specimens is shown to be reliable. Identification of pleomorphic features and necrosis is also reliable despite occasional sampling issues. Assessment of architectural patterns is more limited in cytology.
An efficient revocable identity‐based encryption with ciphertext evolution in the cloud‐assisted system
Authors: Chen Zhiwei , Deng Lunzhi , Ruan Yu , Feng Shuai , Wang Tao , Wang Bo 
Published: May 2023

AbstractIdentity‐based encryption (IBE) is a public key cryptosystem on purpose to remove the traditional certificate management. How to realize efficient user revocation in the IBE is of great importance when considering its application. The drawback of most existing works is that the revoked user can still access the ciphertext prior to revocation. One possible solution proposed by Sun et al. is to evolve the ciphertext in the cloud. However, it is unfortunate that the master time key in their scheme is kept by the private key generator (PKG), which means it is sustained extra burden. In this article, we present an efficient revocable IBE with ciphertext evolution in the cloud‐assisted system and the ciphertext remains constant size. The cloud server keeps only one secret master time update key sent by the PKG in a private channel, and thus our scheme offers scalability. In the meantime, our detailed analysis demonstrates that our proposed scheme is semantically secure against ciphertext chosen attacks based on the k‐CAA problem and enjoys better efficiency in computation and communication costs compared with previous works.
Perfect Core‐Shell Octahedral B@B38+, Be@B38, and Zn@B38 with an Octa‐Coordinate Center as Superatoms Following the Octet Rule
Authors: Yan Qiao‐Qiao , Zhao XiaoYun , Zhang Ting , Li Si‐Dian 
Published: May 2023

AbstractThe front cover artwork is provided by Prof. Si‐Dian Li's group at Shanxi University, China. The image shows the smallest perfect core‐shell octahedral borospherene Oh B@B38+ and its endohedral metallo‐borospherene analogs Oh Be@B38 and Oh Zn@B38 obtained at first‐principles theory. Read the full text of the Research Article at 10.1002/cphc.202200947.
Exciting Enzymes: Current State and Future Perspective of Photobiocatalysis
Authors: Alphand Véronique , van Berkel Willem J. H. , Jurkaš Valentina , Kara Selin , Kourist Robert , Kroutil Wolfgang , Mascia Francesco , Nowaczyk Marc M. , Paul Caroline E. , Schmidt Sandy , Spasic Jelena , Tamagnini Paula , Winkler Christoph K. 
Published: May 2023

AbstractThe recent increase of interest in photocatalysis spread to biocatalysis and triggered a rush for the development of light‐dependent enzyme‐mediated or enzyme‐coupled processes. After several years of intense research on photobiocatalysis, it is time to evaluate the state of the field in a structured manner. In this Perspective, we suggest to group photobiocatalysis into distinct disciplines and provide principal guidelines and standards for the reporting of photobiocatalytic research results as well as advice on performing photobiocatalytic reactions. Overall, we assess that the field contributes to the diversity of biocatalytic reactions while offering the selectivity of enzymes to photocatalysis. We foresee that the ongoing excitement for light‐dependent enzymatic processes will lead to the discovery of novel photobiocatalytic mechanisms to complement biocatalysis with new bond‐forming reactions and will provide additional innovative strategies to utilize light as a possible benign energy source.
Very‐low frequency capacitively coupled AC amplifier with a current feedback operational amplifier
Authors: Beloso‐Legarra Javier , De La Cruz‐Blas Carlos A. , Carlosena Alfonso , Martincorena‐Arraiza Maite 
Published: May 2023

SummaryIn this paper, we propose the idea of using transimpedance amplifiers, in lieu of operational amplifiers (OAs) or transconductance amplifiers (OTAs) to design capacitively coupled AC amplifiers. The idea is demonstrated with a current feedback operational amplifier (CFOA) as an active element, which is actually an architecture consisting of voltage buffers and current copiers (mirrors). This last characteristic is further exploited to make the corner frequency of the AC amplifier tunable by means of bootstrapping low‐valued resistors with the output buffer. It is particularly suited to achieve very‐low corner frequencies as needed in applications such as bio‐ or seismic signals. The idea is demonstrated with simulations and experimental results with a discrete implementation.
Evaluation of cascaded combinations of boost DC–DC converter and three‐winding coupled inductor for high‐voltage gain applications
Authors: Henrique Costa da Silva Bernardo Loureiro Pablo , Spencer Andrade António Manuel Santos 
Published: May 2023

SummaryThis article presents three topologies of high‐voltage gain DC–DC converter based on boost converter with three‐winding coupled inductor. Before proposing these converters, a cascade cell connection synthesizing approach was initially evaluated. This approach allowed the generation of a set of six high‐voltage gain converters. However, only three converters present good performance. Thus, to demonstrate the advantages, disadvantages, and limitations of each converter, the following characteristics are evaluated: the operating principle of the proposed converter, gain of voltage, voltage, and current stress, in addition to the factors of total voltage stress and total current stress, factors that indicate the choice of components with lower intrinsic resistances. To validate these analyses, a 250 W, 30 V/400 V prototype was implemented experimentally, reaching a maximum efficiency of 96%.
CD137 deficiency because of two novel biallelic TNFRSF9 mutations in a patient presenting with severe EBV‐associated lymphoproliferative disease
Authors: Shen Kefeng , Wang Jiachen , Zhou Kuangguo , Mu Wei , Zhang Meilan , Deng Xinyue , Cai Haodong , Zhang Wei , Huang Wei , Xiao Min 
Published: May 2023

AbstractObjectivesIncreasing evidence indicates that some germline genetic mutations that impair pathways required for robust host immune surveillance against EBV infection may result in an extremely high susceptibility to EBV‐associated lymphoproliferative disease (EBV+ LPD). TNFRSF9 encodes a vital costimulatory molecule that enhances CD8+ T‐cell proliferation, survival and cytolytic activity. To date, no relevant case resulting from TNFRSF9 heterozygous mutations has been identified.MethodsHere, we report the first case of CD137 deficiency caused by two novel biallelic heterozygous TNFRSF9 mutations [NM_001561.5: c.208 + 1−>AT and c.452C>A (p.T151K)] in a patient presenting with severe EBV+ LPD. Immunophenotyping and in vitro assays of lymphocyte function and NK cell activity were performed.ResultsBiallelic TNFRSF9 mutations resulted in markedly reduced or abrogated expression of CD137 on activated T, B and NK cells. CD8+ T cells from the patient had impaired activation, reduced expression/release of interferon‐γ (IFN‐γ), tumor necrosis factor‐α (TNF‐α), perforin and granzyme B, and diminished cytotoxic activity. Functional experiments identified both variations were hypomorphic mutations and played a contributing role in CD137 deficiency and the development of EBV+ LPD.ConclusionOur study expands the genetic spectrum and clinical phenotype of patients with CD137 deficiency and provides additional evidence that the TNFRSF9 gene plays a critical role in host immune responses to EBV infection.
Early, concurrent, and consistent hand preferences predict stacking in toddlerhood
Authors: Marcinowski Emily C. , Nelson Eliza L. , Campbell Julie M. , Michel George F. 
Published: May 2023

AbstractStacking is a hallmark of fine motor skill development and requires skilled hand use. One mechanism for children to gain manual proficiency involves establishing a hand preference that creates practice differences between the hands as the preferred hand is used more often and in different ways than the other. Prior work found that stacking skill emerged earlier for infants with an identifiable hand preference. However, it is not known how hand preference relates to later toddler stacking performance. This study examined the effects of early hand preference (infant pattern), concurrent hand preference (toddler pattern), and consistent hand preference (infant to toddler pattern) on toddler stacking skills. Sixty‐one toddlers, whose hand preferences as infants were known, were assessed for their toddler hand preference and their stacking skill across 7 monthly visits from 18 to 24 months of age. Using multilevel Poisson longitudinal analysis, children with hand preferences that were consistent across both infancy and toddlerhood were more successful at stacking, compared to those with inconsistent preferences across the infant and toddler periods. Thus, consistency of hand preferences during the first 2 years likely contributes toward individual differences in the development of fine motor skills.
Increasing stability of a native freshwater fish assemblage following flow rehabilitation
Authors: Jacinto Emily , Fangue Nann A. , Cocherell Dennis E. , Kiernan Joseph D. , Moyle Peter B. , Rypel Andrew L. 
Published: May 2023

AbstractStream restorations are increasingly critical for managing and recovering freshwater biodiversity in human‐dominated landscapes. However, few studies have quantified how rehabilitative actions promulgate through aquatic communities over decades. Here, a long‐term dataset is analyzed for fish assemblage change, incorporating data pre‐ and post‐restoration periods, and testing the extent to which native assemblage stability has increased over time. In the late 1950s, a large capacity dam was installed on Putah Creek (Solano County, CA, USA), which altered the natural flow regime, channel structure, geomorphic processes, and overall ecological function. Notably, downstream flows were reduced (especially during summer months) resulting in an aquatic assemblage dominated by warm‐water nonnative species, while endemic native species subsisted at low levels as subordinates. A court‐mediated Accord was ratified in 2000, providing a more natural flow regime, specifically for native and anadromous fishes in the stream. The richness of nonnative species decreased at every site following the Accord, while the richness of native species increased or stayed constant. At the three most upstream sites, native species richness increased over time and ultimately exceeded nonnative richness. Native assemblage recovery was strongest upriver, closer to flow releases and habitat restoration activities, and decreased longitudinally downstream. Rank–abundance curves through time revealed that, while species evenness was low throughout the study, dominance shifted from nonnative to native species in the upstream sites coincident with rehabilitation efforts. Mean rank shifts decreased following flow rehabilitation; thus the assemblage became increasingly stable over time following flow rehabilitation. Putah Creek's rehabilitation may represent a model for others interested in improving endemic freshwater communities in degraded ecosystems.
An intraosseous myoepithelial carcinoma with a EWSR1::PBX3 fusion
Authors: Haglund Cecilia , Zemmler Maja , Tsagkozis Panagiotis , Haglund de Flon Felix 
Published: May 2023

AbstractHerein we report a case of an intraosseous myoepithelial carcinoma harboring a EWSR1::PBX3 fusion gene. The patient was a 64‐year‐old male found to have a 7 cm destructive lesion in the distal ulna with an extraosseous soft tissue component. Microscopic examination of the resected tumor showed a spindle‐cell lesion within a sclerotic stroma and intravascular tumor emboli. At higher power the tumor cells showed moderate nuclear atypia with a high mitotic count (20 per mm2). Immunohistochemistry revealed diffuse EMA positivity and focal pancytokeratin (AE1/AE3) and S100 expression, consistent with myoepithelial differentiation. NGS using the Oncomine Childhood Cancer Assay (Thermo Fisher Scientific, Inc.) revealed a EWSR1‐PBX3 fusion and ABL amplification. The patient subsequently developed local recurrence as well as distant lymph node, lung and vertebral metastases; he is currently awaiting systemic treatment in the context of a clinical trial. In this report, we present a rare case of a skeletal myoepithelial tumor harboring a EWSR1::PBX3 fusion with demonstrated histological and clinical features of malignancy.
Toward a Long‐Term Low Emission Development Strategy: The Case of Energy Transition in Qatar
Authors: Al‐Noaimi Fadi , Al‐Ansari Tareq , Bicer Yusuf 
Published: May 2023

AbstractThe objective of this paper is to present a comprehensive perspective on the development of a long‐term low‐emission development strategy for Qatar, in line with the Paris Agreement. The methodology used in this paper takes a holistic approach by analyzing national strategies, structures, and mitigation measures from other countries, and synthesizing these with Qatar's unique context in terms of its economy, energy production, and consumption, as well as its energy‐related emission profile and characteristics. The findings of this paper identify key considerations and elements that policymakers would need to take into account when developing a long‐term low‐emission vision for Qatar, with a particular emphasis on its energy sector. The policy implications of this study are significant for policymakers in Qatar, as well as for other countries facing similar challenges in their transition to a sustainable future. This paper contributes to the discourse on energy transition in Qatar and provides insights that can inform the development of potential routes to reduce greenhouse gas emissions in Qatar's energy system. It serves as a foundation for further research and analysis and can contribute to the development of more effective and sustainable policies and strategies for low‐emission development in Qatar and beyond.
Breeding for drought tolerance in perennial ryegrass (Lolium perenne L.) and tall fescue (Lolium arundinaceum [Schreb.] Darbysh.) by exploring genotype by environment by management interactions
Authors: Fernandes Filho Claudio C. , Murad Leite Andrade Mario H. , Rodrigues Nunes Jose A. , Wipff Joseph , Hignight Debra L. , Rios Esteban F. , Kenworthy Kevin , Hignight Kenneth 
Published: May 2023

AbstractBackgroundDrought‐tolerant turfgrass cultivars are becoming more important each year as landscape irrigation practices are becoming more restrictive.MethodsIn this study, we quantified the level of drought tolerance (DT) in perennial ryegrass and tall fescue genotypes across years under different mowing (MH) and fertility (FL) rates. A total of 48 ryegrass and 38 tall fescue genotypes were planted in 2011 at NexGen, Albany, OR. The trial was divided into three subtrials: (i) DT; (ii) MH and DT; and (iii) FL and DT.ResultsThe results showed that there was significant genetic variance for most of the traits in both species. The genotype × year interaction was predominantly simple, indicating small changes in genotype ranking for both species. Lower MH improved DT in perennial ryegrass, whereas higher MH resulted in greater DT in tall fescue. For both species, higher MH improved the population mean for turf quality. Higher FL inputs led to higher turf quality for both species, but it did not affect the DT response.ConclusionsUsing a selection index, six genotypes for perennial ryegrass and four for tall fescue were selected.
Comparison of patient‐reported upper extremity disability following free flaps in head and neck reconstruction: A systematic review and meta‐analysis
Authors: Ranganath Kushi , Miller Lauren E. , Goss Deborah , Lin Derrick T. , Faden Daniel L. , Deschler Daniel G. , Emerick Kevin S. , Richmon Jeremy D. , Varvares Mark A. , Feng Allen L. 
Published: May 2023

AbstractBackgroundComparisons of patient‐reported donor site morbidity based on the Disabilities in Arm, Shoulder, and Hand (DASH) instrument across upper trunk free flaps in head and neck surgery, including radial forearm (RFFF), osteocutaneous radial forearm (OCRFF), scapular tip (STFF), and serratus anterior (SAFF) free flaps, may help inform donor tissue selection.MethodsIn this meta‐analysis, 12 studies were included and the primary outcome was average DASH score.ResultsThe pooled DASH scores were 12.14 (95% CI: 7.40–16.88) for RFFF (5 studies), 17.99 (11.87–24.12) for OCRFF (2 studies), 12.19 (8.74–15.64) for STFF (3 studies), and 16.49 (5.92–27.05) for SAFF (2 studies) and were not significantly different.ConclusionsResults suggest that patients generally function well, with minimal to mild donor site morbidity, when assessed at an average of 20 months after flap harvest. These results are based on few effects from primarily retrospective studies of fair quality, and further research is needed.
Integrated environmental assessment of iron ore tailings in floodplain soils and plants after the Fundão Dam disaster in Brazil
Authors: Melo Vander F. , Lipski Bernardo , Motta Antônio Carlos V. , de Pierri Letícia , Leme Daniela M. , Ercole Tamires M. , D. d. S. Lima Maria Fernanda , Thá Emanoela L. , Bastos Leonardo P. 
Published: May 2023

Abstract
Previous studies of the Doce River basin (Brazil) seem to be contradictory regarding the contamination of soils with potentially harmful elements (PHE). This research aimed to perform an integrated assessment of PHE in the soil–plant–tailing system from the area most affected by the iron waste after the Fundão Dam disaster in 2015. Different fractions of PHE (exchangeable, nonexchangeable, reducible, and pseudo-total) were determined on deposited iron waste (DIW), soil waste mixture (SWM), and control soil (CS) samples. Total contents of PHE in Poaceae were also determined, and Allium cepa bioassays were performed to determine DIW and CS cytotoxicity and/or genotoxicity to plants. The Fe and Mn contaminations were the only ones related to the deposition of DIW on floodplains, and other harmful element content (such as As, Hg, Ni, Cd, Cr, and Pb) was not found above baseline values for soils. In addition, a significant part of the Fe and Mn in DIW is readily available or subject to acidification and prolonged flood reduction processes. The high available content of Fe favored its excessive accumulation by Brachiaria. The DIW chemical conditions reduced biological functions of A. cepa under a controlled environment. However, more drastic effects, such as genetic damage, were not seen. The postdisaster action of covering DIW with CS resulted in undesirable enrichment of Pb on the floodplain soils. The integrated results allow the conclusion that the iron waste is not a time bomb for PHE contamination of soils between the Fundão and Risoleta Neves Hydroelectric Dam (~100 km away from Fundão). Integr Environ Assess Manag 2024;20:117–132. © 2023 SETAC
Nelson syndrome and perinatal challenges: A case report and systematic review of the literature
Authors: Jones Kate , Reis Ines , Levy Miles J. , Potdar Neelam 
Published: May 2023

AbstractNelson syndrome is a rare and potentially life‐threatening complication of treatment with total bilateral adrenalectomy for women with Cushing disease. A successful term pregnancy following fertility treatment in a patient with Nelson syndrome is presented. Our study provides guidance in the prenatal and intrapartum management of this condition. A case report and a systematic review of 14 papers describing 50 pregnancies are presented. An electronic database search included Medline (1946 to September 2022), Embase (1980 to September 2022), Cochrane Library, and UKOSS. A small number of pregnancies in women with Nelson syndrome are reported in literature, but there are no guidelines. Some authors detail the prenatal care provided to their patients. Four studies report prenatal monitoring with visual field checks and two report monitoring with X‐rays. Five studies report the use of parenteral hydrocortisone at the time of delivery. Where described, women delivered appropriately grown newborns at term, with timing and mode of delivery dictated by obstetric indications. Preconception counseling and optimization of maternal health status improve pregnancy outcomes in women with Nelson syndrome. Multidisciplinary review in a combined obstetric‐endocrine prenatal clinic is ideal. Awareness about potential complications during pregnancy and the postnatal period is crucial in providing optimal care to the mother and baby.
Clinical, ultrasonographic, and functional outcomes after obstetric anal sphincter injury primary repair: A single‐center experience
Authors: Frigerio Matteo , D'Alessandro Gloria , Re Ilaria , Cola Alice , Vergani Patrizia , Barba Marta 
Published: May 2023

AbstractObjectiveTo present clinical and instrumental sequelae after obstetric anal sphincter injuries (OASIS), evaluating correlations between intrapartum severity of lesions, postpartum symptoms, and sonographic and manometric findings; outcomes during subsequent deliveries were also evaluated.MethodsThis retrospective study evaluated all consecutive women who sustained an OASIS between 2015 and 2020. Postpartum symptoms, anorectal manometry (ARM), and three‐dimensional endoanal ultrasonography (3D‐EAUS) were analyzed.ResultsA total of 107 women underwent OASIS primary repair; 84 (78.5%) of them were asymptomatic after 1 month. The presence and severity of symptoms showed a great correlation with instrumental outcomes in terms of maximum resting pressure, squeeze pressure increment (SPI), circumferential extension of defect for both external anal sphincter (EAS) and internal anal sphincter (IAS), and EAS, IAS and total Starck scores. There was a significant correlation between ARM and 3D‐EAUS findings, with the exception of SPI, for which the abnormalities were not predictable based on EAUS results.ConclusionBoth ARM and EAUS findings after OASIS are directly related to each other, and associated with symptoms. These instrumental tools may be useful for OASIS assessment and counseling.