bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive role of ABC transporters in the efficacy of enfortumab vedotin for urothelial carcinoma
Authors: Kijima Toshiki , Takada‐Owada Atsuko , Shimoda Hiroki , Kokubun Hidetoshi , Uematsu Toshitaka , Takei Kohei , Betsunoh Hironori , Yashi Masahiro , Ishida Kazuyuki , Kamai Takao 
Published: January 2025

AbstractObjectiveTo evaluate the correlation between ATP‐binding cassette (ABC) transporter expression and therapeutic efficacy of enfortumab vedotin (EV), an antibody‐drug conjugate targeting Nectin‐4, in urothelial cancer, as only a few studies have been conducted on this topic.Patients and methodsThis retrospective study included 20 patients with metastatic urothelial carcinoma (mUC), including bladder and upper urinary tract cancers, who were treated with EV at Dokkyo Medical University Hospital between 2022 and 2024. Immunohistochemical staining was performed on formalin‐fixed, paraffin‐embedded tissue samples. Progression‐free survival (PFS) was estimated using the Kaplan–Meier method, and differences between subgroups (e.g., Nectin‐4 and ABC transporter expression) were compared using the log‐rank test.ResultsImmunohistochemical analysis indicated that tumours with high ABC transporter expression exhibited shorter PFS time and poorer response to EV. Furthermore, a decrease in Nectin‐4 expression and an increase in ABC transporter expression were observed as the disease progressed from non‐muscle‐invasive to muscle‐invasive and metastatic. Patients with Nectin‐4‐positive and ABC transporter‐negative tumours had the longest PFS, underscoring the prognostic significance of these biomarkers.ConclusionTo our knowledge, this study is the first to show a correlation between ABC transporter expression and EV efficacy in urothelial carcinoma. Future research should focus on optimizing treatment strategies based on Nectin‐4 and ABC transporter expression to improve outcomes.
Neuartige Holz‐Beton‐Verbunddecke mit Kerven und Buchenholzdübeln als Verbundlösung
Authors: Mikoschek‐Muggendorfer Michael , Rempel Sergej , Colling François 
Published: January 2025

AbstractHolz‐Beton‐Verbunddecken gehören bereits länger im Bestand und Neubau zum Stand der Technik und finden nun womöglich mit der Technischen Spezifikation DIN CEN/TS 19103 auch Einzug in den künftigen Eurocode 5. Hierbei sind erstmals Kerven als Verbundlösung mit Schrauben zur Abhebesicherung für die Bemessung und Anwendung normativ beschrieben. Trotz dieses Fortschritts bleibt eine flächendeckende Nutzung dieser Bauweise bislang aus. Dies könnte nicht zuletzt an der sehr hohen Anzahl an benötigten Schrauben liegen, weswegen der erhöhte Aufwand häufig gemieden wird. Eine Alternative hierzu ist ein neuartiges Holz‐Beton‐Verbundsystem unter Verwendung von Kerven und Buchenholzdübeln als Abhebesicherung. Diese Verbundlösung ermöglicht einen hohen Vorfertigungsgrad und einen effizienteren Einsatz durch kürzere Bauzeiten. Weitere Effizienzsteigerungen werden durch den Verzicht auf eine vollflächige Bewehrung der Betondeckschicht erreicht, was auch zu ökologischen Vorteilen führt und eine einfachere Rückbaubarkeit ermöglichen soll. In Hinblick auf das Tragverhalten der neuen Verbundlösung wurden experimentelle und numerische Untersuchungen durchgeführt, um damit die Grundlagen für eine baupraktische Anwendbarkeit zu schaffen.
The Impact of EU Taxonomy for Sustainable Activities on European Utilities' Performance
Authors: Tonnarello Federica , Vermiglio Carlo , Migliardo Carlo , Naciti Valeria 
Published: January 2025

ABSTRACTThis study investigates the relationship between European utility companies' compliance with the EU Taxonomy for Sustainable Activities and their overall performance. The EU Taxonomy is a new regulation proposed by the European Commission to promote sustainable finance by 2050. The literature shows that nonfinancial disclosures have a favorable impact on financial performance. However, no research has been conducted to assess the implementation of the EU Taxonomy and its effect on firm performance. Using a sample of European utilities from 2012 to 2022, a difference‐in‐differences (DiD) model was applied to analyze the causal relationship between compliance and performance. Based on institutional and signaling theories, the results show that companies reporting alignment with the Taxonomy exhibit higher market value, profitability, and efficiency than those that do not. This study contributes to firms' transparency and enriches academic discussions by offering insights for policymakers and by improving industry practices.
Non‐Indigenous Canadians' Post‐Colonial Ideologies, Allyship and Collective Guilt Predict Support for Reconciliation, Collective Action and Political Tolerance
Authors: Herkimer Jaiden , Choma Becky , Nasser Leen 
Published: January 2025

ABSTRACTSince the release of the Canadian Truth and Reconciliation Commission's (2015) report and their 94 Calls to Action, there has been a push to advance truth and reconciliation with Indigenous peoples in Canada. Much of the heavy lifting has been done by Indigenous peoples; but to comprehensively redress injustices there is a need for non‐Indigenous support. In two studies with non‐Indigenous Canadians (n = 355; n = 341), we investigated post‐colonial ideologies (historical negation, symbolic exclusion), ally/supporter identity and collective guilt as predictors of support for reconciliation and Indigenous collective action movements, and political tolerance of Indigenous peoples. Consistent with hypotheses, higher post‐colonial ideologies, lower ally/supporter identification and lower collective guilt related to less support and less political tolerance. Collective guilt emerged as a mediator for support for reconciliation and Indigenous collective action (except for symbolic exclusion in Study 1); but it moderated the relations for political tolerance. Collective guilt also moderated relations between symbolic exclusion and ally/supporter identity with support for reconciliation in Study 1. Future directions for advancing understanding of post‐colonial ideologies and possible applied interventions aimed at improving intergroup relations are discussed.
NIR‐II Fluorescence Imaging‐guided Photothermal Activated Pyroptosis For Precision Therapy Of Glioma
Authors: Chen Zhuang , Luo Yi , Jia Qian , Yang Zuo , Liu Zebing , Cui Can , Qiao Chaoqiang , Yang Peng , Wang Zhongliang 
Published: January 2025

AbstractThe resistance of cancer cells to apoptosis poses a significant challenge in cancer therapy, driving the exploration of alternative cell death pathways such as pyroptosis, known for its rapid and potent effects. While initial efforts focused on chemotherapy‐induced pyroptosis, concerns about systemic inflammation highlight the need for precise activation strategies. Photothermal therapy emerges as a promising non‐invasive technique, minimizing pyroptosis‐related side effects by targeting tumors spatially and temporally. However, accurately pinpointing tumors to avoid collateral damage remains a challenge. Thus, we utilize NIR‐II fluorescence imaging to achieve precise PTT‐induced pyroptosis activation in glioma. A polymer semiconductor‐based PTT agent was developed with high optical stability, integrated with mesoporous silica to enhance its biocompatibility. These nanoparticles, stabilized through PEG modification and targeted with cRGD peptides, effectively induced pyroptosis in vitro. Furthermore, this design facilitated precise tumor imaging guidance and subsequent pyroptosis activation in vivo, presenting a promising strategy for glioma therapy with minimized adverse effects.
Extensive Spiculated Follicular Porokeratosis With Alopecia: A Case Report
Authors: Abdolvand Mitra , Radanfar Roya , Sepaskhah Mozhdeh , Sari Aslani Fatemeh , Akbarzadeh Jahromi Mojgan 
Published: January 2025

ABSTRACTFollicular porokeratosis (FPK) is a rare subtype of porokeratosis. Follicular porokeratosis mainly occurs in men and may be localized or diffuse. Involvement of the scalp is rarely reported, and we found only one case of alopecia due to scalp FPK. Diabetes mellitus has not been reported in association with FPK We report a 35‐year‐old diabetic woman that presented with brown follicular keratotic papules and spicules involving the scalp, face, trunk, and extremities, accompanied by scalp alopecia. The differential diagnoses were lichen planopilaris, papular eczema, and phrynoderma. Histopathologic examination of skin punch biopsies revealed the follicle‐centered cornoid lamella as the feature of FPK. The patient was treated with oral isotretinoin, and the lesions improved partially within 6 weeks of follow‐up. Follicular porokeratosis might be considered among the differential diagnoses of keratotic papules (with or without spicules) and in the cases of alopecia with keratotic papules. Diabetes mellitus may be associated with FPK.
Chronic rhinosinusitis with nasal polyps: Key considerations in the multidisciplinary team approach
Authors: Pfaar Oliver , Peters Anju T. , Taillé Camille , Teeling Thijs , Silver Jared , Chan Robert , Hellings Peter W. 
Published: January 2025

AbstractBackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a recurrent inflammatory disease associated with several comorbidities and a significant disease burden for patients. Treatments include corticosteroids and sinonasal surgery, but these can be associated with the risk of adverse events and nasal polyp recurrence. Biologic treatments such as mepolizumab can be used as an add‐on treatment and are effective at reducing surgery and corticosteroid use.Main textPatients with CRSwNP may be seen by a specialist in one of several different areas and often experience delayed diagnosis due to the need to see multiple physicians, as well as misdiagnosis resulting from lack of sufficient expertise within any one speciality. Multidisciplinary team (MDT) approaches have been shown to be effective in optimising the treatment and clinical management of other respiratory diseases, such as aspirin‐exacerbated respiratory disease and severe asthma. In CRSwNP, an MDT approach may reduce diagnostic delays, mitigate secondary disease burden, and reduce overprescription of corticosteroids and antibiotics.ConclusionThis article provides an overview of the patient perspective of MDTs, existing approaches and barriers to adoption, lessons learnt from allied and rare diseases, how to address under‐recognised aspects of CRSwNP, and other key considerations for developing an MDT approach.
Ultrastructural Localization of Glutamate Delta Receptor 1 in the Rodent and Primate Lateral Habenula
Authors: Choi Diane , Paré Jean‐Francois , Dravid Shashank , Smith Yoland 
Published: January 2025

ABSTRACTGlutamate delta receptor 1 (GluD1) is a unique synaptogenic molecule expressed at excitatory and inhibitory synapses. The lateral habenula (LHb), a subcortical structure that regulates negative reward prediction error and major monoaminergic systems, is enriched in GluD1. LHb dysfunction has been implicated in psychiatric disorders such as depression and schizophrenia, both of which are associated with GRID1, the gene that encodes GluD1. Thus, disruption in GluD1 synaptic signaling may contribute to LHb dysfunction and the pathophysiology of LHb‐associated disorders. Despite its strong cellular expression, little is known about the subsynaptic and subcellular localization of GluD1 in LHb neurons. Given that GluD1 is involved in the development and/or regulation of glutamatergic and GABAergic synapses in various brain regions, a detailed map of GluD1 synaptic localization is essential to elucidate its role in the LHb. To address this issue, we used immunoelectron microscopy methods in rodents and monkeys. In both species, GluD1 immunoreactivity was primarily expressed in dendritic profiles, with lower expression in somata, spines, and glial elements. Pre‐ and post‐embedding immunogold experiments revealed strong GluD1 expression in the core of symmetric GABAergic synapses. Albeit less frequent, GluD1 was also found at the edges (i.e., perisynaptic) of asymmetric, putative glutamatergic synapses. Through the combination of anterograde tracing with immunogold labeling in rats, we showed that axon terminals from the entopeduncular nucleus and the lateral hypothalamus express postsynaptic GluD1 immunolabeling in the LHb. Our findings suggest that GluD1 may play a critical role in modulating GABAergic transmission in the rodent and primate LHb.
High Sensitivity of Fine‐Needle Aspiration Calcitonin in Detecting Medullary Thyroid Carcinoma Is Independent of Predefined Decisional Thresholds
Authors: Wolde Sellasie Sium , Amendola Stefano , Guidobaldi Leo , Pedicini Francesco , Nardone Isabella , Piticchio Tommaso , Zaccaria Simona , Scappaticcio Lorenzo , Leoncini Andrea , Uccioli Luigi , Trimboli Pierpaolo 
Published: January 2025

ABSTRACTThe measurement of Calcitonin (Ctn) in fine‐needle aspiration (FNA) washout fluids (FNA‐Ctn) has demonstrated excellent sensitivity, significantly higher than FNA cytology, in detecting medullary thyroid carcinoma (MTC). However, the absence of a fixed cutoff value for FNA‐Ctn poses a limitation. This study aimed to investigate whether the sensitivity of FNA‐Ctn in detecting MTC varies with different cutoffs reported in the literature. A single‐centre series of MTCs was retrospectively reviewed. The preoperative FNA‐Ctn levels were re‐evaluated using various thresholds previously reported in the literature, and the corresponding FNA‐Ctn sensitivities were compared. Twenty‐one MTCs were included (69% women; median age 59 years; median serum Ctn value 86 pg/mL; median MTC major diameter 10 mm). The median FNA‐Ctn value was 2000 pg/mL (interquartile range 49–250). MTCs nodules were assessed at high risk (ACR TI‐RADS 5) in 50% of cases, while 47.6% were cytologically malignant. Additionally, 42.9% of cases were assessed as stage III according to Union for International Cancer Control staging system (UICC). Serum Ctn was significantly lower in stage I (p = 0.04). FNA‐Ctn was positively correlated with serum Ctn (Rho = 0.45; p = 0.04), while ACR TI‐RADS assessment with MTC stage (Rho = 0.69; p = 0.003). FNA‐Ctn sensitivity ranged from 95% to 100% based on the previously proposed FNA‐Ctn cutoffs. The high sensitivity of FNA‐Ctn in detecting MTC did not significantly differ when applying the previously proposed cutoffs. Given the absence of a universally applicable FNA‐Ctn decisional threshold, institutions should establish their own diagnostic cutoffs. Future guidelines should incorporate these concepts to enhance clinical decision‐making and patient outcomes.
Integrated Fuzzy‐Knapsack Based Demand Response Energy Management System for Smart Grid Buildings
Authors: Memon Zulfiqar , Azeem Fawad , Manzoor Tareq , Manzoor Habib Ullah 
Published: January 2025

ABSTRACTDemand response schemes play a vital role in managing the load demand. However, the demand response applicability is pre‐descriptive where loads to be managed are pre‐selected majorly based on the availability of renewable energy and lower tariff rates. However, in hospitality buildings such as hotels, user comfort cannot be compromised by the cost of energy. The arrival of guests is a unique parameter that drives the load consumption regardless of the availability of free energy or lower tariff rates. During higher guest arrivals, pre‐descriptive loads meant to be scheduled during low renewable energy availability and higher tariff rates cannot be compromised over guest comfort. Similarly, pre‐descriptive loads that are already not in operation at the time of low guest arrivals will result in wastage of green power at times of its availability. There is a need to develop an automated demand response that has the liberty to select any load for shifting to renewable energy based on the power they consume to utilize maximum resources without compromising guest comfort. In this research, a novel automated demand response scheme is developed that intelligently selects any load from the building in real time while mapping it with the available capacity of renewable power. A cascaded fuzzy integrated knapsack algorithm is designed for intelligent selection of loads participation in demand response. Based on the availability of solar PV power, grid rates, and load operations, fuzzy designates values to the random operational loads. In the second step, the designated values are given to the Knapsack algorithm to find the best optimal responsive loads to be operated at that time. In the proposed approach, random loads were selected for shifting to renewable power without any prior load selection, which enhances the operation and usability of solar PV power. It was found that 88%–100% of solar PV power was utilized under all simulated scenarios of operation.
A Filtered Embedded Weighted Compact Non‐Linear Scheme for Hyperbolic Conservation Law
Authors: Liu Xuan , Min Yaobing , Cai Jinsheng , Ma Yankai , Yan Zhen‐Guo 
Published: January 2025

ABSTRACTIn situations where a wide range of flow scales are involved, the non‐linear scheme should be capable of both shock capturing and low‐dissipation. Most of the existing Weighted Compact Non‐linear Schemes (WCNS) are too dissipative and incapable of achieving fourth‐order for the two smooth stencils located on the same side of a discontinuity due to the weight deviations and the defect of the weighting strategy. In this paper, a novel filtered embedded WCNS is introduced for complex flow simulations involving both shock and small‐scale structures. To overcome the above deficiency of existing WCNS, a pre‐discrete mapping function is proposed to filter the weight deviation out and amend the inappropriate weights to ideal weights in smooth regions. Meanwhile, the embedded process is also implemented by this function, which is utilized to improve the resolution of shock capturing in certain discontinuity distributions. The pre‐discrete mapping function is also extended to the WENO framework. The approximate‐dispersion‐relation analysis indicates that the scheme with the mapping function has lower dispersion and dissipation error than the WCNS‐JS, WCNS‐Z, and WCNS‐T schemes. Numerical results show that WCNS with the new non‐linear weights captures discontinuities sharply without obvious oscillation, has a higher resolution than other non‐linear schemes, and has an obvious advantage in capturing small‐scale structures.
Threshold Photoelectron Spectrum of 3,4‐Dimethylenecyclobutene
Authors: Karaev Emil , Schaffner Dorothee , Gerlach Marius , Preitschopf Tobias , Hemberger Patrick , Fischer Ingo 
Published: January 2025

AbstractWe report a study on the photoionization of the C6H6 isomer 3,4‐dimethylenecyclobutene, DMCB. The molecule is an intermediate in the formation of benzene from the propargyl radical self‐reaction, a suggested first step in the formation of polycyclic aromatic hydrocarbons and soot. From a threshold photoelectron spectrum we determine an adiabatic ionization energy of 8.75 eV. The geometry change upon ionization is associated with considerable vibrational activity, which is assigned to a symmetric in‐plane bending mode of the =CH2 groups. A breakdown diagram shows that the dissociative photoionization resembles the one observed for benzene. Computations reveal that DMCB cation isomerizes to the benzene cation and dissociates from there.
Non‐differential gut microbes contribute to hypertension and its severity through co‐abundances: A multi‐regional prospective cohort study
Authors: Liu Lu , Zhou Qianyi , Xu Tianbao , Deng Qiufeng , Sun Yuhao , Fu Jingxiang , Chen Muxuan , Chen Xiaojiao , Ma Zhenchao , Dong Quanbin , Ma Beining , Jiao Yuwen , Zhou Yan , Wu Tingting , Zou Huayiyang , Shi Jing , Wang Yifeng , Sheng Yanhui , Tang Liming , Zheng Chao , Wu Wei , Ma Wenjun , Sun Wei , Hu Shixian , Zhou Hongwei , He Yan , Kong Xiangqing , Chen Lianmin 
Published: January 2025

AbstractMicrobial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. While prior research has primarily focused on differential abundances, our study highlights the role of non‐differential microbes in hypertension. We propose that non‐differential microbes contribute to hypertension through their ecological interactions, as defined by co‐abundances (pairs of microbes exhibiting correlated abundance patterns). Using gut microbiome data from the Guangdong Gut Microbiome Project, which includes 2355 hypertensive and 4644 non‐hypertensive participants across 14 regions, we identified replicable hypertension‐related microbial interactions. Notably, most co‐abundances involved non‐differential microbes, which were found to correlate with both hypertension severity and hypertension‐related microbial metabolic pathways. These findings emphasize the importance of microbial interactions in hypertension pathogenesis and propose a novel perspective for microbiome‐based therapeutic strategies.
Identifying the Sources of the Slowdown in Growth: Demand Versus Supply
Authors: Maffei‐Faccioli Nicolò 
Published: January 2025

ABSTRACTLong‐run GDP growth has declined in the United States over the past two decades. Two competing views take centre stage in accounting for this slowdown: the demand‐side view and the supply‐side view. I empirically quantify their relative importance in a Bayesian SVAR with common trends identified using sign restrictions. While supply‐side factors were the main driver of long‐run GDP growth prior to 2000, demand‐side factors explain half of its slowdown afterwards. The findings highlight the importance of demand‐side factors as drivers of long‐run growth.