bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative evaluation of the antioxidant and anti-inflammatory properties of Musa cavendish and Musa paradisiaca pulp and peel extracts from Guinea
Authors: Diawara Mamady , Boukhers Imane , Portet Karine , Duchamp Orianne , Morel Sylvie , Boudard Frederic , Traore Lounseny , Michel Alain , Dhuique-Mayer Claudie , Poucheret Patrick 
Published: August 2023

Banana is one of the most consumed fruits in the world. Musa cavendish and Musa paradisiaca cultivars differential nutrition-health properties and more specifically their antioxidant and anti-inflammatory potential are poorly known. The objective of the present study was to compare the hydroalcoholic dry extracts nutrition-health properties of these two types of Guinea bananas. Total polyphenols contents were evaluated by Folin Ciocalteu method, antioxidant capacity by DPPH, ORAC and Mito-tracker assays. Anti-inflammatory activity was evaluated in vitro on inflammatory macrophages. NO scavenging, NO and cytokines production (TNF-α and IL-6) were assessed. At 1 mg/mL, the extracts showed moderate total polyphenol content. Antioxidant activity potential was depended on the type of extracts. Banana pulps anti-inflammatory effects were demonstrated by the inhibition of NO cell production and NO scavenging suggesting that pulps have moderate anti-inflammatory effect as a function of doses (100, 50 and 25 µg/mL). However, none of the extracts inhibited the production of cytokines (TNF-α and IL-6). The present study indicates that Guinea bananas may be considered as an interesting food source of antioxidants associated to a moderate anti-inflammatory potential on specific inflammation markers.
Keywords: Banana pulp; Banana peel; Antioxidant activity; Anti-inflammatory activity; Polyphenols.
In-Vitro Comparative Study of Levocetirizine Dihydrochloride and Montelukast Sodium Release Profiles in Xyzal M Suspension and Other Marketed Syrup Formulations
Authors: Joshi Devesh Kumar , Veligandla Krishna Chaitanya , Rathod Rahul , Kotak Bhavesh P 
Published: August 2023

Objectives: In-vitro comparative analysis of the release profile of levocetirizine dihydrochloride and montelukast sodium in Xyzal M Suspension and three commercially available syrup formulations.
Method: The active components and their impurities were initially assayed in all formulations using a validated HPLC method. The enantiomeric impurities of montelukast sodium in different pH media were determined using the HPLC method specified in the United State Pharmacopoeia (USP) monograph. Additionally, dissolution studies and the soluble fractions of the components were evaluated in pH media that mimic the conditions of the gastrointestinal tract. The particle size was also analyzed using microscopic analysis. All parameters were examined in fresh, stressed, and aged samples of each formulation.
Results: The assay results indicate the claimed potency of formulations. The total and enantiomeric impurities meet the limits set by the Indian Pharmacopoeia (<2%) and USP monograph (<0.2%), respectively. The particle size analysis demonstrated that montelukast remained suspended throughout the Xyzal M suspension. Levocetirizine in all formulations exhibited a soluble fraction of >70% after 1 and 24 hours in various pH media. For montelukast, the soluble fraction exceeded 50% in all syrup formulations. However, in Xyzal M suspension, montelukast was found to be 100% insoluble in all pH media after 1 and 24 hours, except in simulated intestinal fluid (~40-45%) after 24 hours. The absence of S-enantiomer, even in simulated intestinal fluid, indicates its presence in the pharmacologically active form.
Conclusion: Xyzal M suspension is a promising dosage formulation for achieving desired pharmacological action, outperforming the syrup formulations.
Keywords: Levocetirizine dihydrochloride, Montelukast sodium, Release profile, Suspension, Syrup, S-enantiomer
Validated Simultaneous Derivative Spectrophotometric Estimation of Diflunisal and Lignocaine in Bulk and Pharmaceutical Formulation
Authors: Raskar Manish. A. , Mungse Shweta S , Kate Prajkta A. , Godge Ganesh Raosaheb 
Published: August 2023

Two simple, sensitive, accurate and precise spectrophotometric methods were developed and validated for the quantitative determination of Diflunisal (DIF) and Lignocaine (LIG) in bulk and pharmaceutical dosage form. Method A is based on the first-order derivative (D1), and Method B is based on the second-order derivative (D2) spectrophotometric method. In Method A, absorbance was measured at 224nm and 264nm being the zero crossing points for DIF and LIG, respectively. In Method B, absorbance was measured at 232nm and 273nm being the zero crossing points for DIF and LIG, respectively. For Method A, the two drugs obeyed Beer's law in the concentration range of 3-39µg/ml for DIF and 4-40 µg/ml for LIG with correlation coefficients 0.999 and 0.995, respectively. For Method B, the two drugs obeyed Beer’s law in the concentration range of 3-30µg/ml for DIF and 4-48µg/ml for LIG with correlation coefficients 0.998 and 0.996, respectively. Both methods can be used for routine analysis of these two drugs in their pharmaceutical dosage form. Results for analysis of both methods were tested and validated for various parameters according to ICH guidelines.
Keywords: Derivative, Diflunisal, Lignocaine, first order, second order
Comparative Analysis of Phytochemical and Antioxidative Properties of Different Solvent Extracts of Codium tomentosum Stackhouse for Therapeutic Application
Authors: Babini C K , Reena A 
Published: August 2023

Seaweeds are a phenomenal source of bioactive components in marine environments yet to be explored extensively. The study focused on estimating and identifying phytochemical components, secondary metabolites, and antioxidant efficiency of edible green seaweed Codium tomentosum (Chlorophyta). Qualitative phytochemical analysis of five solvent extracts revealed the presence of Phenol, Flavonoids, Terpenoids, Alkaloids, Tannins, Steroids, Carbohydrates, Glycosides, Amino acids and Proteins. Total phenol content (TPC) equivalent to GAE of five extracts estimated shown highest in chloroform and lowest in methanol - CE (194.53 ± 0.008 mg GAE/g) and ME (138.97 ± 0.007mg GAE/g). Total flavonoid content (TFC) quercetin equivalent (QE) was reported lowest in aqueous extract AE (59.982 ± 0.024 mg QE/g) and highest in chloroform – CE (213.07± 0.014 mg QE/g). The secondary metabolites profile of methanol extract analyzed by GC-MS revealed prominent components, Hexadecanoic acid, Flavones, Oleic acid, Dodecanoic acid, Pentadeconoic acid, and phenol derivative having a spectrum of bioactivity. In vitro, the Antioxidant activity of the five solvent extracts of Codium tomentosum was confirmed by DPPH and ABTS methods. It is evident from the present investigation that the edible green seaweed Codium tomentosum Stack House is a promising source of bioactive components that could be further explored for antimicrobial, anticancer, and antibiofilm properties through green synthesis of nanoparticles for pharmaceutical and nutraceutical applications.
Keywords: Codium tomentosum, phytochemical, GC-MS, anti-oxidative, edible seaweed
Screening of Marketed Formulations of Shatavari Tablets to Establish Pharmaceutical Equivalence
Authors: Sunte Bramhadev Tukaram , Shinde Aditya Navnath , Vaidya Vaibhav Ravindra 
Published: August 2023

Using an in vitro dissolving research, compare the pharmacological equivalent of three brands of Shatavari tablets sold in India. According to IP rules, the dissolution was performed using apparatus I (the paddle device). According to the Indian Pharmacopoeia, evaluation of physicochemical characteristics including weight variation test, content uniformity test, hardness test, friability test, disintegration test, and dissolution test was conducted. For weight fluctuation, content homogeneity, hardness, friability, disintegration time, and dissolving study, all brands complied with official specifications. Two out of the three brands of Shatavari tablets achieved more than 75% dissolve in just 60 minutes, according to the dissolution profile. Out of three brands of Shatavari tablets, the results indicated that two of them had satisfactory quality and had passed all of the pharmacopoeia's tests.
Keywords: Asparagus racemosus, pharmaceutical equivalence, in vitro dissolution.
Prevalence of Depression and Drug Use Pattern among Elderly People in Living in Old Age Homes in Kathmandu
Authors: Rokaya Rabindra Kumar , Lamichhane Suman , Adhikari Atul , Barakoti Himal , Gautam Prayusha , Shrestha Sanu , Acharya Shreeman 
Published: August 2023

Among 150 respondents, 25 [16.67%] respondents were normal. Out of theses 25respondents, 98 [65.33%] and 27 [18%] respondents had mild and severe depression respectively according to GDS. Regarding the socio-demographic information of the respondents, 7.33% were of age 60-64yrs, 10.66% were of 65-69 yrs, 31.33% were of 70-79 yrs, and 51.33 were of >80 yrs. 100 percent of the elderly people were regularly using drugs, and the average patient was regularly using more than 21 drug classes. The most common classes of drugs used by the older people living in Old Age Homes were antihypertensive agents [9.33 %], vitamins [8.67 %], cardiac drugs [3.33%], cardiovascular dilators [2%], laxatives [6%], and tranquilizers [4%], diuretics [6.67%], and least class of drug used was sedatives i.e. [0.67%], and following drugs classes were hypnotics [6%], antidepressants [2.67%], anti-arrhythmic drugs [3.33%], pulmonary drugs [4.67%], antacids [5.33%] and anti-secretary agents [4%].
Keywords: Old age homes, hypnotics, antidepressant, depression, drug pattern
Anatomical study of stifle joint in dogs
Authors: Al-Juhaishi Oday. A. , Khalil Nabaa. Abd. 
Published: August 2023

The stifler is one of the hindlimb joints, described as complicated join consisting of many structures that organized in accurate way to support and stabilize body and hindlimb during the movement. The stifle joint of dogs, equivalent to the knee joint in the human, is a complex composition comprising the tibia, patella femur, menisci, caudal and cranial cruciate ligaments, lateral and medial collateral ligament, also surrounding muscles like hamstring and quadriceps muscles. The long bones (tibia and femur) form this joint, while patella sits in front of it to protect it. The two C-shaped menisci act as shock absorbers, and the supporting ligaments including collateral and cruciate provide stability to the joint. The surrounding muscles, including the quadriceps and hamstring muscles, help to extend and flex the joint, respectively. Together, these structures work in harmony to allow for the complex movement of dogs’ stifle joint.
Understanding the anatomical features of the stifle joint in dogs is important for diagnosing and treating injuries or conditions that affect this complex joint
Clinical and some Risk Factors Associated With Theileria .spp in cows of Salah AL-Din Governorate,Iraq
Authors: Hamad Rafal Ali , Mahmoud Omaima Ibrahim , Saber Maher 
Published: August 2023

The current study aimed to diagnosis Theileria spp in cattle by using microscopic examination of blood smears , to record the clinical signs appearing on animals infection and to investigate the relationship between the infection and some risk factors such as sex ,age and presence of ticks on the animal. Fifty blood samples were collected during the period from September 2021 to the end of December 2022 from different areas in Salah Al-Din government (Al-Hamra, Albu Ajil, Baiji, AL-Alam ). The animals were suffering from one or more of clinical signs ( high temperature, lack of appetite, lethargy, pallor mucous membranes, superficial lymphadenopathy and tick infection) . The results showed that the total rate of infection was 40% . No significant differences between age groups, with 30% in animals that are less than a year and 16% 1-2 years and 10% in 2-3 years . and 4% in age 3< The study registered a significant difference according to gender, the rate of infection in male was 22 % and in females was 18%
Pengaruh Disiplin, Beban Kerja, Dan Inovasi Terhadap Kinerja Pegawai Pada PT Prima Duta Nusantara
Authors: Nafisah Fida , Syarifuddin  
Published: August 2023

Tujuan dilakukannya penelitian ini adalah untutk mengetahui dan mengalisis bagaimana disiplin kerja, beban kerja, dan inovasi berpengaruh terhadap kinerja karyawan PT Prima Duta Nusantara. Penelitian ini menggunakan metode kuantitatif dengan jenis penelitian deskriptif dan kausalitas. Pengambilan sampel dilakukan menggunakan metode non-probability sampling dengan jenis sampel jenuh untuk pengumpulan data dan jumlah responden sebanyak 40 responden PT Prima Duta Nusantara. Teknik analisis data yang digunakan adalah analisis deskriptif dan analisis regresi linier berganda. Hasil penelitian secara parsial menunjukan bahwa disiplin kerja memiliki pengaruh positif dan signifikan terhadap kinerja karyawan, beban kerja memiliki pengaruh positif dan signifikan terhadap kinerja karyawan, inovasi memiliki pengaruh positif dan signifikan terhadap kinerja karyawan. Secara simultan, disiplin kerja, beban kerja, dan inovasi memiliki pengaruh signifikan terhadap kinerja karyawan dengan Hal ini menunjukan bahwa pengaruh variabel independen yaitu disiplin kerja, beban kerja, dan inovasi terhadap variabel dependen yaitu kinerja karyawan adalah 45% sedangkan sisanya 55% dipengaruhi oleh faktor lain yang tidak diteliti dalam penelitian ini.
Kata Kunci: Manajemen Sumber Daya Manusia, Disiplin Kerja, Beban Kerja, Inovasi, Kinerja Pegawai.
PENGARUH CITRA MEREK, HARGA, KUALITAS PRODUK TERHADAP LOYALITAS PELANGGAN DENGAN KEPUASAN KONSUMEN SEBAGAI VARIABEL INTERVENING
Authors: Hidayah Sinta Nur , Nugroho Rusdi Hidayat 
Published: August 2023

Penelitian ini adalah studi tentang pengaruh citra merek, harga dan kualitas produk terhadap loyalitas pelanggan dengan kepuasan konsumen sebagai variabel intervening pada brand miniso. Tujuan dari penelitian ini untuk mengetahui apakah variabel citra merek, harga dan kualitas produk berpengaruh terhadap loyalitas pelanggan melalui variabel intervening yaitu kepuasan konsumen. Metode penelitian yang digunakan adalah metode path analysis (Analisis Jalur). Sampel dalam penelitian di tarik dengan menggunakan metode purposive sampling dengan jumlah sampel sebanyak 100 responden yang diambil dari populasi konsumen brand miniso.Hasil dari uji sobel pada path analysis menunjukkan bahwa citra merek dan harga tidak berpengaruh terhadap loyalitas pelanggan dengan kepuasan konsumen sebagai variabel intervening dimana keduanya memiliki nilai t hitung kurang dari t tabel. Kualitas produk memiliki pengaruh terhadap loyalitas pelanggan dengan kepuasan konsumen sebagai variabel intervening, hal ini karena nilai t hitung lebih besar dari nilai t tabel. Citra merek tidak memiliki pengaruh terhadap loyalitas pelanggan. Harga, kualitas produk dan kepuasan konsumen memiliki pengaruh terhadap loyalitas pelanggan. Perusahaan harus mampu untuk mempertahankan dan memberikan kualitas produk yang baik untuk menciptakan rasa puas dalam diri konsumen dan membuat konsumen bersifat loyal.
Research on the Implication of the Concept of a Community with a Shared Future for Mankind from the Perspective of Marxism
Authors: Xie Yeman 
Published: August 2023

The concept of a community with a shared future for mankind is the inheritance and development of Marxist philosophy, a major theoretical achievement of the Sinicization of Marxism in the new era, and the core concept of contemporary Chinese diplomacy. Based on Marxist philosophy and scientific socialism, this article systematically expounds the basic composition of the concept and value system of a community with a shared future for mankind and discusses its rich connotations and significance to society, so as to promote a comprehensive grasp and deep understanding of it.
The Safe Learning Environment in the United Arab Emirates Schools and Its Relationship to the Development of Creative Thinking Among Students
Authors: AlKhaza’leh Mohammad Salman , Obeidat Bilal F. , Abdel-Hadi Samer , Al-Qaruty Reema 
Published: August 2023

The study aimed to assess the relationship between a safe learning environment in Emirati schools and the development of student's creative thinking. Using a descriptive method with stratified random sampling, the researchers selected a sample of 500 male and female teachers. Two questionnaires were employed: one assessing the safe learning environment (20 items) and another measuring creative thinking (20 items). Results indicated a high teacher perception of a safe learning environment, with statistically significant chi-square values for all items. Similarly, teachers perceived a high level of creative thinking development, with significant chi-square values for all items. Gender and experience did not show statistically significant differences in the perception of a safe learning environment. However, teachers with over 10 years of experience demonstrated higher levels of creative thinking development. Notably, a significant correlation was found between a safe learning environment and the development of students' creative thinking in Emirati schools. This study aligns with the UAE Ministry of Education's mission to create a safe and creative educational system that meets the needs of a globally competitive knowledge society. Doi: 10.28991/ESJ-2023-SIED2-014 Full Text: PDF
Determinants of the Realization of Second Chance Education
Authors: Pasternáková Lenka , Barnová Silvia , Zelina Miron , Krásna Slávka , Gabrhelová Gabriela 
Published: August 2023

The aim of the study is to present a newly developed research instrument examining the determinants of second chance programmes’ success or failure from the perspective of teachers. In the theoretical part of the study, the authors elaborate on the issues of second chance education and focus on factors having a direct impact on the results of its realization. Subsequently, the Second Chance Education Indicators Questionnaire developed by the authors, the results of the carried out internal factorial analysis, as well as the calculated correlations, are presented. Based on the gathered data from 1,038 teachers, seven factors – "Satisfying employers’ needs in the field of education"; "Promoting the development of teachers’ competencies for second chance education"; "Providing teachers with support in developing their professional skills in the field of second chance education"; "Funding schools providing second chance education"; "The system of dual VET in second chance education"; and "Potentials for increasing the quality of second chance education" – were identified, and the existence of an internal factorial structure was confirmed. Since there is no other available research tool for identifying these determinants, it can be assumed that the Second Chance Education Indicators Questionnaire is a unique research tool, which can be used for further research activities and can contribute to broadening the current knowledge in the field. Doi: 10.28991/ESJ-2023-SIED2-015 Full Text: PDF
Numerical Behavior of Extended End-Plate Bolted Connection under Monotonic Loading
Authors: Gjukaj Anita , Salihu Fidan , Muriqi Ali , Cvetanovski Petar 
Published: August 2023

Extended end-plate connections, which act as joints providing resistance against moments between beams and columns, are commonly categorized as semi-rigid or partial-strength connections. The reason for their extensive application in steel frame constructions lies in their straightforward design, their ability to be reproduced easily, and the convenience they offer in the fabrication process. This research used the ABAQUS FE software to construct a three-dimensional finite element model (FEM) with the main objective of exploring how different geometric parameters impact the behavior of the extended end-plate bolted connection, which functions as a semi-rigid, partial-strength beam-to-column connection. Accurately determining the moment-rotation relationship and connection stiffness is of utmost importance for semi-rigid connections. The developed FEM models incorporate various factors such as geometric and material non-linearities, bolt pretension force, as well as contact and sliding between the connection elements. To establish the credibility of the numerical outcomes, the developed FEM model was meticulously calibrated and verified against experimental data obtained from previous studies available in the literature. Subsequently, using the validated finite element model, a parametric investigation was undertaken to evaluate the influence of distinct geometric parameters, namely the thickness of the end plate and column web stiffeners. This numerical model facilitates a comprehensive analysis of the extended end-plate bolted connection, encompassing critical aspects such as the moment-rotation curve and failure mode. The results demonstrated that the analyzed finite element model aligns well with experimental findings and that the use of column stiffeners is inevitable in the joint, as well as a moderated thickness of the end plate. Doi: 10.28991/HIJ-2023-04-02-04 Full Text: PDF
El Subsidio al empleo en México como herramienta para frenar la inflación
Authors: Salas Chávez Rocío 
Published: August 2023

Ante los niveles elevados de inflación que experimenta nuestro país, es necesaria la búsqueda de mecanismos que permitan a los trabajadores que perciben un ingreso mensual equivalente al salario mínimo, la satisfacción de sus necesidades básicas. La propuesta de esta investigación de tipo documental descriptiva, sugiere actualizar el esquema conocido como subsidio al empleo, ya que la tabla utilizada en el cálculo para la obtención de la cantidad a entregar al trabajador no ha tenido la debida actualización contenida en la ley contemplada en el caso de que la inflación alcance los dos dígitos, por lo que, el subsidio al empleo en México, podría resultar obsoleto en un futuro cercano, en el caso de seguir incrementándose el salario mínimo en los niveles que ha experimentado en los últimos años, lo cual significaría la pérdida de un doble beneficio, en el caso de los trabajadores, reciben mayores ingresos incrementando su poder adquisitivo, y al provenir el ingreso de un subsidio, no se considera como un incremento a su ingreso salarial, lo que generaría un mayor pago de contribuciones. En el caso de los empresarios, las cantidades que, en su carácter de patrones, entregan a sus trabajadores por la aplicación del subsidio, se reducen de sus pagos periódicos de impuesto sobre la renta, derivando en un manejo más eficiente de sus finanzas.
Zur (De-)Differenzierung von Prädiktion und Prävention: Begriffliche und ethische Überlegungen
Authors: Paul Norbert W. , Münch Nikolai , Mahdiani Hamideh 
Published: August 2023

Abstract
Ausgehend von den Verheißungen einer P4-Medizin, die sich nicht nur als personalisiert und partizipativ, sondern auch als prädiktiv und präventiv versteht, wird der Frage nachgegangen, inwieweit die Entwicklung der Medizin die beiden Konzepte der Prädiktion und der Prävention zunehmend verklammert und wie zwischen ihnen differenziert werden kann. Es werden verschiedene mögliche Verständnisse von Vorhersage und Vorbeugung in Verbindung mit Public-Health-Genomik und der potenziellen Ausweitung der Verantwortung des Einzelnen auf Kosten der öffentlichen Gesundheit untersucht, um die ethischen Konsequenzen einer zunehmenden praktischen Entdifferenzierung zu reflektieren.
Prävention von Bewegungsmangel-assoziierten Erkrankungen: Sachstand und Desiderate
Authors: Joisten Christine , Starke Dagmar 
Published: August 2023

Abstract
Trotz des Wissens um den gesundheitlichen Nutzens von Bewegung nimmt, verschärft durch die COVID-19 Pandemie, die körperliche Aktivität immer weiter ab. Eine Trendwende zeichnet sich trotz zahlreicher Maßnahmen nicht ab. Gründe hierfür liegen in einer fehlenden strukturell verankerten Prävention, geringer Vernetzung verschiedener Stakeholder und Akteur:innen sowie uneinheitlicher, kaum qualitätsgesicherter Herangehensweisen. Hier ist insbesondere die Politik gefordert, Rahmenbedingungen auf Basis der aktuellen Evidenz zu definieren und diese im Präventionsgesetz zu verankern.