bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Does Green Finance Boost Carbon-Neutral Performance? -- Evidence from China
Authors: Hou Hui , Qu Pengsheng , Zhang Minglang 
Published: July 2023

Abstract
Using Chinese provincial sample data from 2011–2021, the paper uses a Durbin spatial model and a threshold panel model to test hypotheses on the relationship between green finance and carbon-neutral performance. The study found that (1) green finance development would promote carbon-neutral performance; (2) there are notable spatial characteristics of green finance and carbon neutrality performance, with local carbon neutrality performance being influenced by local and neighboring green finance; (3) green finance impacts carbon-neutral performance at a single threshold, and different levels of green finance development affect carbon-neutral performance differently. In the eastern, central, and western regions, the contribution of green finance to carbon-neutral performance gradually decreases. Thus, Chinese authorities should strengthen the green sustainable financing system, promote regional green finance, and enhance the carbon-neutral performance of green finance.
Baicalin Target Protein, Annexin A2, is a Target of New Antitumor Drugs
Authors: Kusakabe Yoshio , Matsumoto Kazuya , Tsuyuki Takahiro , Hayashi Yasuhiro , Watanabe Hideaki 
Published: July 2023

Abstract

Baicalin is a flavonoid extracted from Scutellaria baicalensis Georgi. As it has significant antitumor and apoptosis-inducing effects, baicalin may be useful in new antitumor drug development. However, as the pharmacological actions of baicalin have yet to be elucidated, we isolated its target protein, which was successfully identified as Annexin A2. Annexin A2 forms a heterotetramer with S100A10 protein, which plays an important role in the plasminogen activator system. The heterotetramer bound to tissue plasminogen activator (tPA) activates the conversion of plasminogen to plasmin and promotes the expression of STAT-3 and NF-κB, which are target genes involved in the development of cancer. Moreover, NF-κB and STAT-3 induce the expression of cell inhibitors of apoptotic proteins (cIAPs) and inhibit apoptosis. To examine whether these antitumor and apoptosis-inducing effects of baicalin are mediated by Annexin A2, we prepared Annexin A2 knockdown HepG2 cells. We compared mRNA expression by RT-qPCR and apoptosis by caspase-3 activity assays in Annexin A2 knockdown HepG2 cells. The results showed that the antitumor and apoptosis-inducing effects of baicalin are mediated by Annexin A2. The results of this study suggest that agents capable of inhibiting Annexin A2 may be useful candidates for the development of novel antitumor agents.
Risk factors for stoma-and-incision-related complications in children with very early-onset inflammatory bowel disease: A prospective cohort study
Authors: Xu Xiaofeng , Zhou Yiwen , Tan Zhixing , Huang Ying , Dong Kuiran , Gu Ying , Chen Jie , Huang Yuyan , Gou Zhaoyang , Yu Zhuowen 
Published: July 2023

Abstract
Objective
To describe the incidence of postoperative complications of enterostomy and explore the related risk factors in children with very early-onset inflammatory bowel disease (VEO-IBD).
Methods
Forty-three children with VEO-IBD who underwent enterostomy from January 2015 to December 2021 were included. Patients were divided into two groups according to whether they had complications after the enterostomy. The T-test and the Chi-square test were used to analyze the influencing factors of two groups of enterostomy complications. Factors screened out by univariate analysis were included in binary logistic regression.
Results
There were 23(53.5%) VEO-IBD patients who had ostomy complications, 16(37.2%) patients who had peristomal complications, and 15 (34.9%) patients who had incision complications after enterostomy. Univariate analysis showed that there were significant differences in Weight-for-Age Z Score (WAZ), Height-for-Age Z Score (HAZ), and weighted Pediatric Crohn's Disease Activity Index (wPCDAI) among groups with and without complications (P < 0.05). Further multivariate logistic regression analysis showed that wPCDAI was an independent risk factor for stoma-and-incision complications after enterostomy in children with VEO-IBD (P = 0.02, OR = 1.13, 95%CI = 1.02–1.25).
Conclusion
wPCDAI score should be fully considered before the enterostomy procedure in children with VEO-IBD.
Interstitial carbon in an active RuO2 catalyst and its stabilization under low temperature CO2 methanation reaction conditions
Authors: Concepcion PATRICIA , Tébar-Soler Carmen , Diaconescu Vlad Martin , Simonelli Laura , Missyul Alexander , Perez-Dieste Virginia , Villar-Garcia Ignacio , Brubach Jean Blaise , Roy Pascale , Corma Avelino 
Published: July 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
The prevalence of mild cognitive impairment in breast cancer patients receiving chemotherapy according to the criteria of the National Institute on Aging-Alzheimer’s Association (NIA-AA).
Authors: Albers Elaine , Kieffer J.M. , Schagen S.B. 
Published: July 2023

Abstract

Purpose
Breast cancer patients receiving chemotherapy can develop cognitive impairment. There is no gold standard for defining cognitive impairment. We applied the National Institute on Aging- Alzheimer’s Association (NIA-AA) criteria for mild cognitive impairment (MCI) to determine its prevalence in breast cancer patients receiving adjuvant chemotherapy and examine differences between patients with and without MCI.
Methods
Existing cognitive data of 240 breast cancer patients who received adjuvant conventional (n = 154) or high-dose chemotherapy (n = 86) on 5 neuropsychological test outcomes measuring verbal memory, processing speed, executive functioning and verbal fluency was used. Testing occurred 6 or 12 months post-chemotherapy and results were compared to 66 women without cancer. MCI was defined by; i) presence of concern regarding a change in cognition, ii) impairment in one or more cognitive tests (1.5 Standard Deviation below a normative mean), iii) preservation of independence in functional abilities, and iv) no dementia.
Results
20% (n = 49) of breast cancer patients who received chemotherapy (conventional therapy n = 29 (12%), high-dose therapy = 20 (8.3%)) met criteria for MCI, compared to 7.6% (n = 5) of controls. Prevalence was significantly different between the groups (P = 0.020) and corrected for IQ (P < 0.001). Patients with MCI had significant lower education levels (P < 0.002) and premorbid IQ (P = 0.001) compared to patients without MCI.
Conclusion
20% of breast cancer patients treated with chemotherapy met NIA-AA criteria for MCI, compared to 7.6% of the controls. These criteria, which include formal test performance as well as a person's symptoms and functional status, can be useful in clinical practice and scientific research.
Integrated Magnetless Passive Broadband Faraday Isolator
Authors: Lapointe Jerome , Coia Cedrik , Vallée Réal 
Published: July 2023

Abstract

Optical isolation based on a non-reciprocal effect is crucial for proper operation of several high-performance photonic devices such as LiDAR and quantum platforms. The magneto-optical Faraday rotation is the most commonly used non-reciprocal effect as it offers unique advantages, including broadband operation, wide input optical power range, low insertion losses and high optical isolation, but it is currently not conducive to miniaturization. Two major impediments hinder the direct integration of Faraday isolators into photonic integrated circuits (PICs): the need for bulky external magnets, and the challenging fabrication of low-loss waveguides that would eliminate the need for free-space coupling optics. We have addressed both challenges using a first-of-its-kind femtosecond laser writing technique to create waveguides within the bulk of latched bismuth-doped iron garnet (BIG) slabs without altering its magneto-optic functionality. As a result, we have achieved a magnetless Faraday rotator waveguide exhibiting <0.15 dB insertion loss with a record high figure of merit of 346° dB-1. By interposing this Faraday rotator between two 30 μm-thick polarizers, we further demonstrate an integrated magnetless optical isolator with >25 dB isolation ratio and <1.5 dB insertion loss over the entire optical telecom C-band.
Universal Eye Screening: Perinatal Risk Factors &amp; Ocular Pathologies in 1795 Newborns Not Meeting Retinopathy of Prematurity Criteria
Authors: Khanna Rohit , Nayak Sameera , Padhy Tapas , Mettla Asha Latha 
Published: July 2023

Abstract

Objectives: This prospective cohort study aimed to investigate the ocular outcomes of universal eye screening in newborns and assess the relationship between different perinatal risk factors and various ocular pathologies in infants who do not meet the criteria for retinopathy of prematurity (ROP) screening.
Methods: A universal eye screening questionnaire was utilised to screen newborn babies who did not meet the ROP screening criteria within 72 hours of birth at a public and private hospital between June 2016 to April 2018. The questionnaire covered demographic characteristics, neonatal history, and eye examination findings. A trained retina specialist conducted comprehensive anterior and posterior segment examinations utilising a binocular indirect ophthalmoscope.
Results: Out of the 1795 newborns screened, 55.2% were male, and 44.8% were female. The most prevalent ocular pathology observed was retinal haemorrhage (RH), with a prevalence of 10.64% (95% CI: 9.25% – 12.16%). The prevalence of non-RH pathology was 7.5% (95% CI: 6.34% – 8.84%). Multivariable analysis revealed that RH was associated with normal vaginal deliveries (OR: 10.1; 95% CI: 6.9-15), while non-RH pathologies were associated with preterm birth (OR: 5.6; 95% CI: 3.5-9.0), consanguinity (OR: 2.3; 95% CI: 1.3-4.1), low birth weight (OR: 8.8; 95% CI: 5.1-15.1), and systemic abnormalities (OR: 3.3; 95% CI: 2.0-5.3).
Conclusions: Sight-threatening ocular pathology in newborns may be linked to perinatal risk factors such as preterm birth, low birth weight, consanguinity, and systemic abnormalities. Therefore, targeted eye screening for newborns in this high-risk group is warranted.
Synthesis, anticancer evaluation and docking studies of novel adamantanyl-1,3,4-oxadiazol hybrid compounds as Aurora-A kinase inhibitors
Authors: Jaber Areej Majed , Al-Mahadeen Mohammed M , Al-Qawasmeh Raed A , Taha Mutasem O 
Published: July 2023

Abstract
Cancer is a devastating disease, but advancements in cancer treatment offer hope for the future. Aurora Kinases are a family of serine/threonine kinases that play critical roles in cell cycle control and mitosis. There are three members of the Aurora kinase family in humans: Aurora-A kinase, Aurora-B kinase, and Aurora-C kinase. This study focuses on the synthesis of hybrid compounds combining adamantane and 1,3,4-oxadiazole as potential inhibitors of Aurora-A kinase. A series of novel 4-((5-((3r,5r,7r)-adamantan-1-yl)-1,3,4-oxadiazol-2-yl)thio)-N,N-2-yn-1-amine were synthesized and evaluated against Aurora-A kinase. The most potent derivatives were 6a and 6k with IC50 values 36.6 and 38.8 μM, respectively. Docking studies probed the binding interactions of these compounds within the active site of the kinase. The findings contribute to the development of novel cancer therapeutics and offer promise for more effective and targeted treatments in the future.
Implementing the time-to-event continualreassessment method in the presence of partial orders in a phase I head and neck cancer trial.
Authors: Patel Amit , Brock Kristian , Slade Daniel , Billingham Lucinda , Gaunt Piers , Gaunt Claire , Kong Anthony , Mehanna Hisham 
Published: July 2023

Abstract
Background: In this article we describe the methodology of the time-to-event continual reassessment method in the presence of partial orders (PO-TITE-CRM) and the process of implementing this trial design into a phase I trial in head and neck cancer called ADePT-DDR. The ADePT-DDR trial aims to find the maxi­mum tolerated dose of an ATR inhibitor given in conjunction with radiotherapy in patients with head and neck squamous cell carcinoma.
Methods: The PO-TITE-CRM is a phase I trial design that builds upon the time-to-event continual reassessment method (TITE-CRM) to allow for the pres­ence of partial ordering of doses. Partial orders occur in the case where the monotonicity assumption does not hold and the ordering of doses in terms of toxicity is not fully known.
Results: We arrived at a parameterisation of the design which performed well over a range of scenarios. Results from simulations were used iteratively to deter­mine the best parameterisation of the design and we present the final set of simulations. We provide details on the methodology as well as insight into how it is applied to the trial.
Conclusions: Whilst being a very efficient design we highlight some of the dif­ficulties and challenges that come with implementing such a design. As the issue of partial ordering may become more frequent due to the increasing investiga­tions of combination therapies we believe this account will be beneficial to those wishing to implement a design with partial orders.
Trial registration: ADePT-DDR was added to the European Clinical Trials Database (EudraCT number: 2020-001034-35) on 2020-08-07.
Investigation of the expression of Long non-coding RNA in Parkinson's disease
Authors: Mazdeh Mehrdokht , Farsani Mohesn Khosravi , Komaki Ali Rezae , Eftkharin Mohammad Mehadi 
Published: July 2023

Abstract
Background and aim
Parkinson's disease is the second chronic age-related neurodegenerative disease after Alzheimer's. Pathogenic factors in Parkinson's include inflammation and oxidative stress, which lead to dopaminergic cell apoptosis. The case-control study aims to determine the expression level of long non-coding RNAs (lncRNAs) of the apoptosis pathway in Parkinson's patients with healthy individuals.
Methods
In the case-control study, 50 patients with Parkinson's disease were examined, with 50 healthy individuals matched in age and sex. In both groups, the expression of long non-coding RNAs includes taurine up-regulated 1(TUG1), metastasis associated lung adenocarcinoma transcript 1(MALAT1) ،nuclear enriched abundant transcript 1(NEAT1), and Growth Arrest Specific 5(GAS5) were compared using Real-time polymerase chain reaction (PCR.)
Results
MALAT1, NEAT1, and TUG1 gene expression ratio in the case group was statistically significantly higher than in healthy individuals. The ratio of GAS5 gene expression in people with Parkinson's disease was lower, with a statistically significant difference. The ratio of HULC gene expression was higher in the case group, but it did not show a statistically significant difference with the control group.
Conclusion
The involvement of long lncRNAs that increase apoptosis may play a role in the pathogenesis of the disease, which may be used for identification and therapeutic purposes.
Dietary bile acids improve breast muscle growth in chickens through FXR/IGF2 pathway
Authors: Chen Liang , Shi Yanghong , Li Jinbao , Ma Shuai , Shen Chao , Shao Caimei , Zhao Ruqian 
Published: July 2023

Abstract

Background
Fast-growing broiler chickens are commonly fed diets with high-fat content, particularly in integrated farms in Northeast China. Therefore, the efficiency of fat digestion, absorption, and utilization is critical for broiler meat production. Bile acids (BA) promote fat digestion and absorption, yet whether and how BA affects muscle growth in broiler chickens remain unclear.
Results
In this study, one-day-old broiler chickens were fed diets of low, medium, and high levels of crude fat with or without BA supplementation, for 42 days (d). Chickens fed BA-supplemented high-fat diet had significantly (P < 0.05) higher body weight (BW) at 21 d and average daily gain (ADG) from 1 to 21 d, compared to all the other groups. Feed conversion rate (FCR) was significantly (P < 0.05) lower in high-fat group, which was further decreased (P < 0.05) with BA supplementation. The improved growth performance in BA-supplemented high-fat group was associated with significantly (P < 0.05) increased lipase activity in the chyme of small intestine, a trend of decrease (P = 0.06) in abdominal fat ratio, and significantly (P < 0.05) higher breast muscle mass. Further histological analysis revealed significant (P < 0.05) increases in myofiber diameter, cross-sectional area, as well as RNA and DNA content in the breast muscle of BA-supplemented broiler chickens on high-fat diet. Accordantly, genes related to muscle growth, including mTOR, MYH1B, and PAX7, are significantly (P < 0.05) upregulated. These changes were accompanied by significantly (P < 0.05) increased concentration of insulin-like growth factor 2 (IGF2) in serum, liver and breast muscle. The upregulation of IGF2 gene in the breast muscle of broiler chickens fed BA-supplemented high-fat diet was associated with significantly (P < 0.05) increased FXR protein content and FXR binding to IGF2 gene promoter.
Conclusions
These results suggest that dietary BA supplementation improves FCR and breast muscle growth through FXR-mediated IGF2 pathway in broiler chickens fed high-fat diet.
A fuzzy overlapping project resource optimization model in the project construction industry, using a fractal method
Authors: Zohrehvandi Shakib , Knapčíková Lucia 
Published: July 2023

Abstract
When the number of projects in a company increases, it becomes very important to choose the right strategy to supply resources and raw materials in profit and loss and finish the work according to the schedule. This study presents a new mathematical model using the fractal method to optimize the resource planning system in project-oriented construction and industrial companies, and the results are analyzed. In the model proposed in this research, a fuzzy method and an overlapping method are used. Using the method of Pentagonal fuzzy numbers in determining the appropriate number of resources for project activities, as well as using a method of overlapping activities to determine the appropriate time of overlapping activities will lead to optimal use of project resources. This article aims to introduce a fuzzy overlapping project resource optimization (FOPRO) model in project-oriented construction and industrial companies by providing a fractal framework to minimize resource costs and the smooth flow of materials between projects to meet the existing demand. Assuming three levels of headquarters, regions, and projects, each of them in the collection is a self-similar structure defined as a fractal. The study was carried out in one of the contracting companies in the industrial and construction fields, which operates as a project-oriented project in different regions of the country. To evaluate the proposed model, the obtained results were compared with the results of previous models. The results showed that the model presented in this research was able to create optimization in terms of sending machines, material and manpower between different centers.
Investigating the effect of Zinc supplementation on the metabolic profile and expression of Nrf2, PPARγ and IL-10 genes in patients undergoing Methadone Maintenance Treatment: A Randomized, Double-Blind, Placebo- Controlled Trial
Authors: Ghaseminejad Azam , Ghaderi Amir , Ghotloo Somayyeh , Akbari Hossein , Bahmani Fereshteh , Aghadavood Esmat , Banafsheh Hamid Reza , Aboutalebian Hadis , Research Nejat Kheiripour. 
Published: July 2023

Abstract
Background: Methadone maintenance treatment (MMT) is associated with immunity dysfunction, increased inflammation, oxidative stress, and DNA damage. Zinc has various effects, including antioxidant and anti-inflammatory effects. In addition, zinc-finger proteins act as transcription factors regulating the expression of genes. In this study, we investigated the effect of Zinc supplement on the metabolic, and oxidative stress profiles, and expression of IL-10, NRF2, and PPARγ genes in heroin patients under MMT.
Methods: Randomized double-blind placebo-controlled clinical trial was carried out on 60 patients under MMT to receive 30 mg/day Zinc supplement (n=30) or placebo (n=30). Fasting blood samples were collected at the baseline and 12 weeks after intervention to quantify related markers, including metabolic, oxidative stress, and gene expression.
Results: At the end of the intervention, Zinc levels was significantly elevated in the intervention group in comparison with the placebo group (p=0.03). In addition, consuming Zink significantly changed the levels of HDL (p=0.04), insulin (p=0.01) and HOMA-IR (p=0.01). As well as the concentration of NO (p=0.02), GSH (p=0.01), TAC (p=0.04) were statistically significant between two groups. Taking Zink upregulated NRF2 gene expression (p< 0.05) in peripheral blood mononuclear cells of patients under MMT.
Conclusion: Results of this study indicated that, Zinc supplement can be recommended as an adjunct to MMT which may have beneficial effects on metabolic profile, oxidative stress, and gene expression and decrease methadone side effects.
Risk-Controlled Student Prescription Trees
Authors: Lentini Maria R. , Thayasivam Umashanger 
Published: July 2023

Abstract
Student Prescription Trees (SPTs) are interpretable policy trees which utilize a blackbox “teacher” model to predict counterfactuals on the basis of observed covariates and a interpretable decision tree (DT) “student” model which sorts datapoints into axis aligned partitions such that the sum over predicted coun-terfactuals outcome variables within each partition is optimized greedly. In this paper, we maintain this basic framework but experiment with a Bayesian hierarchical binomial regression model as the teacher, and require all gains acquired from DT splits to be statistically significant given the posterior distributions over outcome variables from any two disjoint partitions of the data when compared to their unity. This setup allows us to control the uncertainty (i.e., “risk”) associated with a deepening of the complexity (i.e., “depth”) of the student policy, and gives us natural tree growth stopping criteria. In general, fewer datapoints or greater variation are viewed as containing more uncertainty, and therefore greater uncertainty will result result in shallower tree policies, and vice versa.
Analysis of the driving effect of urban compactness on urban innovation capacity
Authors: Li Qingwen , Zhao Peihong , Yang Zhichen 
Published: July 2023

Abstract
Theoretically, we analyzed the mechanism of urban compactness affecting urban innovation capacity, and empirically analyzed the relationship between urban compactness and urban innovation capacity and its driving effects based on the measurement of compactness in 31 large and medium-sized cities. The findings of the study demonstrate that urban compactness plays a crucial role in promoting urban innovation capacity. Specifically, there are notable variations in the impact based on regional and city size heterogeneity. In terms of regional heterogeneity, the compact development of central and western cities leads to a significant enhancement of urban innovation compared to their eastern counterparts. Moreover, regarding city size heterogeneity, increased compactness in larger cities exhibits a positive influence on urban innovation capacity, while the compact development mode of megacities does not significantly impact innovation development. Furthermore, the influence mechanism of urban compactness on urban innovation capacity operates through multiple pathways, including the direct effect, knowledge spillover effect of human capital, agglomeration economy effect of industrial diversity, and the time-space compression effect of transportation access.