bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarker Profiles and Immunologic Predictors of Neurodevelopment in Children who are HIV Exposed Uninfected
Authors: Egler Ashley , Jang Jeong Hoon , Li Wei , McHenry Megan , Oyungu Eren , Yu Qigui , Khaitan Alka 
Published: January 2023

Background: Children who are HIV-exposed uninfected (HEU) have higher morbidity and mortality rates than their unexposed uninfected counterparts (HU). HEU also exhibit lower neurodevelopmental outcomes. Previous studies show that HIV-induced immune dysregulation can be linked to decreased neurodevelopment in HIV+ children. However, the role of inflammation on neurodevelopment in HEU remains unclear.
Methods: This study investigated the plasma levels of 81 biomarkers in 82 Kenyan children between the ages of 18 and 36 months. Neurodevelopment was measured using the Bayley Scales of Infant and Toddler Development, 3rd edition. Bayesian model averaging was used to identify significant biomarkers.
Results: HEU showed lower levels of 12 different proinflammatorycytokines/chemokines/growth factors: IL-12, leukemia inhibitory factor (LIF), macrophage migration inhibitory factor (MIF), TNF-related weak inducer of apoptosis (TWEAK), and A proliferation inducing ligand (APRIL); BLC, eoxtaxin-2, I-TAC, monokine induced by gamma interferon (MIG), and MIP-3a; fibroblast growth factor-2 (FGF-2) and granulocyte colony-stimulating factor (G-CSF). HEU showed higher levels of 2 inhibitory soluble immune checkpoints: T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) and CD40. Bayesian model averaging identified the biomarkers to best predict HEU vs. HU status were IL-12, IL-13, and CD40. In HU children, hepatocyte growth factor (HGF) and IL-5 predicted cognitive scores, BLC and IL-7 predicted motor outcomes, and IL-1a, IL-2R, IL-5, and maternal education predicted language scores. In HEU, FGF-2 predicted language scores, and IL-22 predicted motor development. Statistical analysis identified IL-2R and IL-22 as the strongest predictors of neurodevelopmental outcomes in HU and HEU, respectively.
Conclusion/Potential Impact: This study shows that HEU exhibit an immune suppressive biomarker profile, rather than an inflammatory profile as indicated in previous studies. The significant biomarkers we found may be used to determine children at risk of decreased poor neurodevelopmental outcomes, allowing more time for intervention.
Creating Interactive Digital Anatomy Modules for the Indiana University School of Medicine Human Structure Course
Authors: Farrell Rowan , Eckel Christine , Mas Jose 
Published: January 2023

Background and Hypothesis: The Human Structure (HS) course at Indiana University School of Medicine (IUSM) wascondensed from 115 contact hours over 34 weeks to 96 hours over 17 weeks in 2016. The current course is delivered via block schedule over 10 weeks. A 2016 institutional review of IUSM found that examination scores after the curricular change were significantly lower than those prior to 2016. The data regarding the effect of similar curricular change in U.S. medical programs is mixed. There are consistent findings that interactive, streamlined, manipulatable, and testable review materials support learning and retention of information better than passive review. We hypothesize that incorporating interactive anatomy quiz modules created specifically for the statewide HS course at IUSM will improve learner acquisition of gross anatomy.
Methods and Results: Using high-quality dissection photographs, we constructed 11 interactive learning modulesincluding the lower extremity, abdomen, pelvis, and muscles of facial expression (MOFE).Modules adhered to the Session Learning Objectives and Structures to Know lists for the course. We built modules in PowerPoint, then made them interactive and easily quizzable in Canvas using HTML5 Package (H5P). Modules were peer-reviewed by two anatomy professors and a third collaborator. The Urogenital Triangle and MOFE modules have been fully approved by the CMT for inclusion in the 2022 Course. We expect additional approval of all completed modules.
Potential Impact: We expect that providing students with native interactive modules for gross anatomy will make learning more efficient and reduce the time students spend searching for adequate practicematerials from outside sources. We expect this will improve student learning and increase examination scores.
Perceived professionalism and its relationship with communication skills, social interaction and attitude towards medical subjects among undergraduate medical students in Malaysia
Authors: Rahman M. Mizanur , Raman Daneish , Anthony Elvyronna , Hazwani Nor Syamimi , Iffah Nurul 
Published: January 2023

Background: Professionalism is an essential core competency in medical education in line with societal expectations. It is expected that the medical professionals show a specified set of behaviours and attitudes towards patients and society. This study assessed professionalism and its relationship with undergraduate medical students’ communication competency skills, learning attitude, and social interaction.
Methods: This was a cross-sectional-correlation study conducted among undergraduate medical students irrespective of gender and nationality. A total of 319 students’ data were collected using a validated self-administered questionnaire. The collected data were analysed using IBM SPSS version 27.0. Pearson’s moment correlation and multiple linear regression analysis were done to identify the potential predictors of perceived medical professionalism. A p value of less than 0.05 was considered statistically significant.
Results: The study showed that professional relationship was significantly correlated with a positive attitude on communication skill (p<0.001), environmental control (p<0.001), interaction management (p<0.01), immediacy (p<0.01), attitude towards the medical subject (p<0.001). However, no statistically significant correlation was found between perceived empathy and age, gender, year of study, parental education and previous CGPA (p>0.05).
Conclusions: The study found an interrelationship between professionalism, communication skills, interpersonal communication, and attitude towards medical subjects. However, the multivariate analysis revealed different weightage of influence to professionalism. Further advanced analysis is warranted to get the impact of each of the contributing variables to academic achievement.
Review on phytochemical composition and pharmacological activities of Bixa orellana
Authors: Raju Senthil Kumar , Chandrasekar Sabarainath , Vengadhajalapathy Priyadharshini , Sundaram Revathy , Periyasamyy Sangeetha , Chinnaraj Thatchayani , Sekar Praveen , Kumar Shridharshini 
Published: January 2023

commonly known as Annatto is a lipstick tree belonging to the family Indigenous populations in Brazil and other tropical nations have employed for a variety of therapeutic purposes which is also known as "". The essential natural apocarotenoid obtained from seeds namely bixin is broadly applied as a cosmetic and textile colorant. The carotenoids, which contribute to more than 80% of the annatto seed coat are responsible for the color orange-red. It is well known for its medicinal value and as a coloring agent. Annatto is used in food dye, body paint and the treatment of heartburn and it also reduces inflammation and blood sugar. The various parts of this plant has been reported to show many therapeutic indications like anti-bacterial, anti-hyperglycaemic, anti-histaminic, anti-diarrheal, anti-cancer, anti-inflammatory and anti-oxidant activities. Carotenoids, apocarotenoids, terpenes, terpenoids, sterols and aliphatic compounds are the main compounds found in all parts of this plant. The various annatto plant parts have been utilized in traditional medicine for both the prevention and treatment of a variety of health issues. This review aimed to report the primary evidence found in the literature, concerning the pharmacological activities and phytochemical studies related to . Regarding its application in food, cosmetics, leather, solar cells and other industries, significant research has already been done and is presently being conducted. This review demonstrates the well-studied pharmacological effect that might be relevant for the upcoming creation of a novel therapeutic medication.
ILHAS DE BELÉM – MAPEANDO VULNERABILIDADES SOCIOAMBIENTAIS
Authors: Rocha Gilberto de Miranda , Rocha Emílio Chaves , Barata Clícia Julie Batista , Soares Daniel Araújo Sombra 
Published: January 2023

O presente artigo objetiva contribuir com a identificação, mapeamento e análise dos espaços de vulnerabilidade socioambiental na área insular do Município de Belém do Pará, a fim de contribuir para a elaboração do mapa do território adscrito à Atenção Básica à Saúde, tendo em vista contribuir com as políticas e ações de saúde, a tornar operativo e significativo o atendimento da população.
BENCANA GLOBAL COVID 19 : EKONOMI, POLITIK, & AGAMA
Authors: Mustafa Mus Tafa 
Published: January 2023

Abstrak

Fenomena global pandemi Virus Corona (Covid-19), menjadi perhatian Negara-negara di dunia, karena telah mempengaruhi perekonomian, polirik maupun kegiatana keagaman secara global, semua sector mengalami kerugian yang sangat besar dan dirasakan oleh seluruh sector mulai dari usaha kecil, menengah maupun besar, begitu pula yang di rasakan oleh tingkatan kelas manusia sebagai pengelola usaha, dari yang miskin, menjadi lebih miskin lagi, dari yang menengah menjatuh miskin, dan dari yang kaya menjadi menengah. Dampak perekonomian global akibat wabah virus corona bisa lebih buruk daripada yang diperkirakan sebelumnya. Berbagai indikator memperlihatkan dampak ekonomi, politik, maupun keagamaan akibat covid 19 ini lebih besar daripada krisis ekonomi global tahun 2008 khususnya negara Indonesia. Tulisan ini bertujuan untuk mengurai, dan menggali peran ekonomi, politik dan agama, dalam membangun kembali semangat ekonomi, politik maupun keagamaan yang sudah lesu, masjid, gereja, wihara dll, sebagai tempat ibadah dan kegiatan sosialnya agar segera di kembalikan sebagai mana fungsi semestinya, dan Negara sebagai pengelola sumber daya alam, maupun sumber daya manusia untuk mencapai kesejahteraan masyarakatnnya.

Kata Kunci: Fenomena Global Covid 19: Ekonomi, Politik & Agama
Pengembangan Modul Pembelajaran Tata Rias Pengantin Barat Di Program Studi Pendidikan Tata Rias
Authors: Regina Apriliyandy Syahla 
Published: January 2023

Modul adalah suatu bahan ajar pembelajaran alternatif yang isinya relatif singkat dan spesifik yang disusun untuk mencapai tujuan pembelajaran. Modul dapat dipergunakan untuk pembelajaran mandiri. Dengan modul, peserta didik dapat mengukur sendiri tingkat penguasaan materi yang ada. Penelitian ini bertujuan untuk mendeskripsikan pengembangan media modul pembelajaran dalam materi Tata Rias Pengantin Barat di program studi Pendidikan Tata Rias. Modul ini diharapkan menjadi media alternatif materi Tata Rias Pengantin Barat, sehingga dapat dijadikan sumber yang layak diterapkan bagi mahasiswa. Penelitian ini merupakan penelitian awal yang termasuk di dalam tahap pendefinisian dalam prosedur penelitian dan pengembangan (R&D) oleh Al-Tabany (2014). Penelitian ini hanya terbatas pada analisis kebutuhan yang bersumber dari skala literatur dan hasil wawancara awal pada mata kuliah Tata Rias Pengantin Barat. Sasaran penelitian dan pengembangan yang digunakan sebagai objek dalam penelitian ini adalah mahasiswa Program Studi Pendidikan Tata Rias Universitas Negeri Jakarta yang sudah mengambil mata kuliah Tata Rias Pengantin Barat Tahun 2015 dan 2016. Hasil penelitian ini adalah modul sebagai media pembelajaran dibutuhkan digunakan sebagai bahan ajar mandiri dan bisa menarik minat siswa serta pengembangan media modul sebagai bahan ajar yang bervariasi di program studi Pendidikan Tata Rias.
PEMANFAATAN EKSTRAK KENTAL KULIT BATANG SECANG (Caesalpinia sappan L) SEBAGAI ZAT PEWARNA PADA SEDIAAN BLUSH ON COMPACT
Authors: Fitri Zulfa 
Published: January 2023

Blush on (Rouge) merupakan serbuk warna yang dipadatkan dan menghasilkan warna yang sangat nyata. Tujuan dari penelitian ini adalah untuk mengetahui hasil dari sediaan blush on compact dengan 3 formula yang berbeda dan untuk mengethui hasil evaluasi sediaan tersebut. Formula dibedakan pada seberapa banyak kandungan dari pewarna secang tersebut karena untuk mendapatkan formula yang bagus dan sesuai bagi kulit manusia di Indonesia. Metode ekstraksi yang dilakukan untuk mengambil zat warna pada kayu secang dengan menggunakan metode maserasi agar warna yang dihasilkan lebih pekat dan menggunakan etanol 70%. Teknik analisis data yang dipakai pada penelitian ini merupakan data primer yaitu data yang diperoleh dari sediaan pewarna pipi meliputi: uji pH, uji daya lekat, uji homogenitas, uji organoleptik, dan uji poles. Berdasarkan uji organoleptik yang dilakukan selama satu bulan menandakan bahwa tidak adanya perubahan warna dan kestabilan yang baik. Hasil pemeriksaan uji homogenitas dan uji poles bahwa tidak adanya butiran kasar dan warna yang tidak merata.hasil uji pH berkisar antara 6-7 (sesuai dengan pH kulit normal) dan tidak menmbulkan iritasi sehingga aman digunakan pada kulit.
Kata Kunci: Blush on, ekstrak kulit batang secang, teknik analisa data.
Islamic Banking Sustainability in Indonesia
Authors: Malini Helma 
Published: January 2023

<p><em>Corporate governance exists to increase and maintain shareholder value. On this basis, corporate governance is argued to be vital to any company's long-term viability. To determine how transparency and accountability affected the Islamic banking sector's long-term viability. The study was guided by three theories: agency theory, stewardship theory, and stakeholder theory. This study is quantitative. It is used in quantitative research to generate numerical data or data that can be transformed into statistics. Transparency, accountability, justice, and responsibility are all important factors in the study's findings. Transparency and accountability appear to have a significant impact on the banking industry's long-term viability. To achieve sustainability, Islamic banks in Indonesia should strictly enforce transparency in all operations and worker activities.</em></p><p><em> </em></p>
Pesantren’s Counseling Guidance Services Management-Based Character Education
Authors: Rahmawati Rukhaini Fitri 
Published: January 2023

<p>The character crisis makes Indonesian education urgently need improvement through the educational transformation that not only prioritizes cognitive but also develops the student's skills and character. This study aims to determine the relationship and contribution of counseling guidance services in <em>pesantren</em> to children's character education through service management analysis. The researcher used qualitative research methods with triangulation for data collection. The evaluation instrument involves the Stufflebeam evaluation components. They are context, input, process, and product. The results indicate that the planning and controlling management functions have not been able to function properly and have caused problems in the provided services. The service types have led to increased competence, improved attitudes, and students’ character. However, there were many obstacles in the process. They are funding, infrastructure, implementation time, control from the leadership and administration as well as regular reporting of activities. These conditions have an impact on the role and effectiveness of counseling guidance in assisting <em>santri</em> to maximize their potential and achieve their developmental tasks.</p>
The Role of Profitability in Moderating Political Connections, Corporate Risk, Leverage, And Firm Size to Tax Avoidance
Authors: Lala Latifatul Lala , Kristiana Ida , Hanum Ayu Noviani 
Published: January 2023

This study examines the effect of political connection, corporate risk, leverage, and firm size on tax avoidance with profitability as a moderating variable. The data used are annual financial reports of food and beverage registered in the Indonesia Stock Exchange (IDX) for the 2018-2021. The sample used was 99 companies, obtained using a purposive sampling technique. The data analysis used is Multiple Linear Regression and Moderated Regression Analisis (MRA). In this study, there is a novelty, namely the addition of profitability as a moderating variable, because, in previous studies, the use of moderation with the same independent and dependent variables was not found in this study. The result of this study shows that political connection, corporate risk, and firm size do not affect tax avoidance. Meanwhile, leverage has a significant positive effect on tax avoidance. In addition, profitability can moderate the effect of firm size on tax avoidance. However, profitability cannot moderate the effect of political connection, corporate risk, and leverage on tax avoidance. Based on these results, the implication of this study is that leverage in companies must be considered because the greater the level of corporate leverage, the lower the tax burden borne by the company so that debt becomes a management priority to avoid a larger tax burden. Therefore, the greater the leverage ratio, the greater the level of corporate tax avoidance. Likewise, profitability can moderate the effect of company size on tax avoidance must also be considered because the larger the size will enable the company to earn high profits. The firm value will also increase, so the company can control tax avoidance.
Purification of L-Amino acid oxidase obtained from Aspergillus terreus MZ769058 and its biochemical characterization
Authors: Yadav Monika , Agarwal Shefali , Agarwal Sushant , Singh Priyanka 
Published: January 2023

Abstract
L-Amino acid oxidase has significant values in different biotechnology sectors. In this study, Aspergillus terreus MZ769058 had been reported as new fungal isolate for production of this enzyme. It was partially purified using ammonium sulfate precipitation methodology with87.9 U/mg protein maximal specific activity and1.69 folds purification fold for 30–60% saturation. Ion-exchange chromatography was further applied for achieving high value of purification fold (2.55) and high specific activity as 132.5 U/mg.This purified enzyme showed homodimer nature with molecular weight of subunit as 90 kDa and 180 kDa by SDS electrophoresis and NATIVE PAGE respectively. The activity of enzyme was found as maximum 193.5 U/l at optimum value of pH 6.0.The enzyme was active throughout a wide range of temperatures and showed maximum activity (227.08U/l) at optimum temperature 30°C. The value of Michaelis parameters of Km and Vmaxwas estimated as 26 mM and 250 µmole/min/mg proteinsrespectively. The catalytic efficiency of this enzyme (Kcat) value was determined as 2.5 µmole/min/mg. Metal ions such as FeSO4 (85.4 %), Na2MO4 (81.2 %), and CuSO4 had showed negative effect on the activity of LAAO enzyme. Metal ions like MgSO4, H3BO3, and ZnSO4had showed very little effect on activityof L-Amino acid oxidase. The activity of LAAO enzyme was strongly inhibited at a concentration of 10 mM CaCl2.This enzyme was strongly inhibited with α-napthol (34.4%), EDTA (34.2%), Glycine (39%) sodium azide (41.4%), and riboflavin (85.3%). Fourier transform infrared spectroscopyhad confirmed the presence of the amine and aldehyde groups with C-H stretch, C=O stretch, C-O stretch at peak of 2927.95, 1745.25, and 1078.64 cm-1. This enzyme could be effectively used for effective therapeutic agent in pharmaceutical sector.
Nrh L11R single nucleotide polymorphism, a new prediction biomarker in breast cancer, impacts endoplasmic reticulum-dependent Ca2+ traffic and chemotherapy outcome
Authors: Minh Quang , Gadet Rudy , Treilleux Isabelle , Borel Stéphane , Nougarède Adrien , Marcillat Olivier , Gonzalo Philippe , Mikaelian Ivan , Popgeorgiev Nikolay , Rimokh Ruth , Gillet Germain 
Published: January 2023

Abstract
Overexpression of Bcl-2 proteins such as Bcl2L10, also referred to as Nrh, is associated with resistance to therapy and poor survival in various cancers, including breast cancer, lung cancer and leukemia. The single nucleotide polymorphism (SNP) of BCL2L10 in its BH4 domain at position 11 (BCL2L10 Leu11Arg, rs2231292), corresponding to position 11 in the Nrh open reading frame, is reported to lower resistance towards chemotherapy, with patients showing better survival in the context of acute leukemia and colorectal cancer. Using cellular models and clinical data, we aimed to extend this knowledge to breast cancer. We report that the homozygous status of the Nrh Leu11Arg isoform (Nrh-R) is found in 9.7–11% percent of the clinical datasets studied. Furthermore, Nrh-R confers higher sensitivity towards Thapsigargin-induced cell death compared to the NrhL isoform, due to altered interactions with IP3R1 Ca2+ channels in the former case. Collectively, our data show that cells expressing the NrhR isoform are more prone to death triggered by Ca2+ stress inducers, compared to Nrh-L expressing cells. Analysis of breast cancer cohorts revealed that patients genotyped as Nrh-R/Nrh-R may have a better outcome. Overall, this study supports the notion that the rs2231292 Nrh SNP could be used as a predictive tool regarding chemoresistance, improving therapeutic decision-making processes. Moreover, it sheds new light on the contribution of the BH4 domain to the anti-apoptotic function of Nrh and identifies the IP3R1/Nrh complex as a potential therapeutic target in the context of breast cancer.
GIS-Based Assessment of Noise Pollution: A Study of Jamshedpur City, India
Authors: Pahari Subhasish , Chatterjee Nilanjana Das , Barman Nilay Kanti 
Published: January 2023

Abstract
Excessive noise levels in the urban environment is a challenging issue in the sustainable urban development. Determine the noise level and noise affected areas for formation of proper plan is the significant theme of contemporary urban research work. Jamshedpur is the rapid growing industrial urban area in Jharkhand state of India. At present, this city has started to face a severe noise pollution due to rapid industrial growth, high population growth, commercial activity, and increase in transport mode along with legal and illegal construction. Therefore, the present study has been carried out to assess the urban environmental noise pollution in the study area. Several noise indicators like L10,L50,L90, Equivalent continuous noise level (Leq), Noise pollution level (Lnp), Noise Climate (NC), Traffic Noise Index (TNI), Noise Exceeding Factor (NEF), Day-night noise level () have been computed and GIS techniques also considered to determine the scenario of noise level along with their Spatio-temporal variation in the study area. Correlation and regression have been used to assess the relationship between noise levels, traffic volume, and traffic speed. The result indicates that 35 data sampling sites out of 47 sites have affected serious noise pollution and this pollution is partially affected by the volume of traffic flow. The living inhabitants of this area face noise pollution-related issues. To solve the serious noise pollution related problem in Jamshedpur Urban Agglomeration (JUA) present endeavour are very necessary to formulate some strategies and regulations as well as their implementation.