bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel HCP (heparin-binding protein-C reactive protein-procalcitonin) inflammatory composite model can predict severe acute pancreatitis
Authors: Kong Deshuai , Lei Zhang , Wang Zhenyong , Yu Meng , Li Jinchao , Chai Wei , Zhao Xiulei 
Published: June 2023

AbstractSevere acute pancreatitis (SAP) presents with an aggressive clinical presentation and high lethality rate. Early prediction of the severity of acute pancreatitis will help physicians to further precise treatment and improve intervention. This study aims to construct a composite model that can predict SAP using inflammatory markers. 212 patients with acute pancreatitis enrolled from January 2018 to June 2020 were included in this study, basic parameters at admission and 24 h after hospitalization, and laboratory results such as inflammatory markers were collected. Pearson's test was used to analyze the correlation between heparin-binding protein (HBP), procalcitonin (PCT), and C-reactive protein (CRP). Risk factors affecting SAP were analyzed using multivariate logistic regression, inflammatory marker models were constructed, and subject operating curves were used to verify the discrimination of individual as well as inflammatory marker models and to find the optimal cut-off value based on the maximum Youden index. In the SAP group, the plasma levels of HBP, CRP, and PCT were 139.1 ± 74.8 ng/mL, 190.7 ± 106.3 mg/L and 46.3 ± 22.3 ng/mL, and 25.3 ± 16.0 ng/mL, 145.4 ± 67.9 mg/L and 27.9 ± 22.4 ng/mL in non-SAP patients, with a statistically significant difference between the two groups (P < 0.001), The Pearson correlation analysis showed a positive correlation between the three values of HBP, CRP, and PCT. The results of the multivariate logistic regression analysis showed that HBP (OR = 1.070 [1.044–1.098], P < 0.001), CRP (OR = 1.010 [1.004–1.016], P = 0.001), and PCT (OR = 1.030[1.007–1.053], P < 0.001) were risk factors for SAP, and the area under the curve of the HBP-CRP-PCT model was 0.963 (0.936–0.990). The HCP model, consisting of HBP, CRP, and PCT; is well differentiated and easy to use and can predict the risk of SAP in advance.
Surface modification of polycaprolactone nanofibers through hydrolysis and aminolysis: a comparative study on structural characteristics, mechanical properties, and cellular performance
Authors: Yaseri Raziye , Fadaie Milad , Mirzaei Esmaeil , Samadian Hadi , Ebrahiminezhad Alireza 
Published: June 2023

AbstractHydrolysis and aminolysis are two main commonly used chemical methods for surface modification of hydrophobic tissue engineering scaffolds. The type of chemical reagents along with the concentration and treatment time are main factors that determine the effects of these methods on biomaterials. In the present study, electrospun poly (ℇ-caprolactone) (PCL) nanofibers were modified through hydrolysis and aminolysis. The applied chemical solutions for hydrolysis and aminolysis were NaOH (0.5–2 M) and hexamethylenediamine/isopropanol (HMD/IPA, 0.5–2 M) correspondingly. Three distinct incubation time points were predetermined for the hydrolysis and aminolysis treatments. According to the scanning electron microscopy results, morphological changes emerged only in the higher concentrations of hydrolysis solution (1 M and 2 M) and prolonged treatment duration (6 and 12 h). In contrast, aminolysis treatments induced slight changes in the morphological features of the electrospun PCL nanofibers. Even though surface hydrophilicity of PCL nanofibers was noticeably improved through the both methods, the resultant influence of hydrolysis was comparatively more considerable. As a general trend, both hydrolysis and aminolysis resulted in a moderate decline in the mechanical performance of PCL samples. Energy dispersive spectroscopy analysis indicated elemental changes after the hydrolysis and aminolysis treatments. However, X-ray diffraction, thermogravimetric analysis, and infrared spectroscopy results did not show noticeable alterations subsequent to the treatments. The fibroblast cells were well spread and exhibited a spindle-like shape on the both treated groups. Furthermore, according to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the surface treatment procedures ameliorated proliferative properties of PCL nanofibers. These findings represented that the modified PCL nanofibrous samples by hydrolysis and aminolysis treatments can be considered as the potentially favorable candidates for tissue engineering applications.
Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma
Authors: Yagi Kohei , Shimada Shu , Akiyama Yoshimitsu , Hatano Megumi , Asano Daisuke , Ishikawa Yoshiya , Ueda Hiroki , Watanabe Shuichi , Akahoshi Keiichi , Ono Hiroaki , Tanabe Minoru , Tanaka Shinji 
Published: June 2023

AbstractHepatocellular carcinoma (HCC) imposes a huge global burden, arising from various etiological factors such as hepatitis virus infection and metabolic syndrome. While prophylactic vaccination and antiviral treatment have decreased the incidence of viral HCC, the growing prevalence of metabolic syndrome has led to an increase in non-viral HCC. To identify genes downregulated and specifically associated with unfavorable outcome in non-viral HCC cases, screening analysis was conducted using publically available transcriptome data. Among top 500 genes meeting the criteria, which were involved in lipid metabolism and mitochondrial function, a serine transporter located on inner mitochondrial membrane SFXN1 was highlighted. SFXN1 protein expression was significantly reduced in 33 of 105 HCC tissue samples, and correlated to recurrence-free and overall survival only in non-viral HCC. Human HCC cells with SFXN1 knockout (KO) displayed higher cell viability, lower fat intake and diminished reactive oxygen species (ROS) production in response to palmitate administration. In a subcutaneous transplantation mouse model, high-fat diet feeding attenuated tumorigenic potential in the control cells, but not in the SFXN1-KO cells. In summary, loss of SFXN1 expression suppresses lipid accumulation and ROS generation, preventing toxic effects from fat overload in non-viral HCC, and predicts clinical outcome of non-viral HCC patients.
Regional source apportionment of trace metals in fine particulate matter using an observation-constrained hybrid model
Authors: Liao Kezheng , Zhang Jie , Chen Yiang , Lu Xingcheng , Fung Jimmy C. H. , Ying Qi , Yu Jian Zhen 
Published: June 2023

AbstractTrace metals in fine particulate matter (PM2.5) are of significant concern in environmental chemistry due to their toxicity and catalytic capability. An observation-constrained hybrid model is developed to resolve regional source contributions to trace metals and other primary species in PM2.5. In this method, source contributions to primary PM2.5 (PPM2.5) from the Community Multiscale Air Quality (CMAQ) Model at each monitoring location are improved to align better with the observation data by applying source-specific scaling factors estimated from a unique regression model. The adjusted PPM2.5 predictions and chemical speciation data are then used to generate observation-constrained source profiles of primary species. Finally, spatial distributions of their source contributions are produced by multiplying the improved CMAQ PPM2.5 contributions with the deduced source profiles. The model is applied to the Pearl River Delta (PRD) region, China using daily observation data collected at multiple stations in 2015 to resolve source contributions to 8 trace metals, elemental carbon, primary organic carbon, and 10 other primary species. Compared to three previous methods, the new model predicts 13 species with smaller model errors and 16 species with less model biases in 10-fold cross validation analysis. The source profiles determined in this study also show good agreement with those collected from the literature. The new model shows that during 2015 in the PRD region, Cu is mainly from the area sources (31%), industry sector (27%), and power generation (20%), with an annual average concentration as high as 50 ng m−3 in some districts. Meanwhile, major contributors to Mn are area sources (40%), emission from outside PRD (23%) and power generation (17%), leading to a mean level of around 10 ng m−3. Such information is essential in assessing the epidemiological impacts of trace metals as well as formulating effective control measures to protect public health.
Comparative transcriptomic analysis reveals the underlying molecular mechanism in high-fat diet-induced islet dysfunction
Authors: Wan Shengrong , An Ying , Fan Wei , Teng Fangyuan , Jiang Zongzhe 
Published: June 2023

Abstract
Obesity, characterized by accumulation of adipose, is usually accompanied by hyperlipidemia and abnormal glucose metabolism, which destroys the function and structure of islet β cells. However, the exact mechanism of islet deterioration caused by obesity has not yet been fully elucidated. Here, we fed C57BL/6 mice with a high-fat diet (HFD) for 2 (2M group) and 6 months (6M group) to construct obesity mouse models. Then, RNA-based sequencing was used to identify the molecular mechanisms in HFD-induced islet dysfunction. Compared with the control diet, a total of 262 and 428 differentially expressed genes (DEGs) were identified from islets of the 2M and 6M groups, respectively. GO and KEGG enrichment analysis revealed that the DEGs up-regulated in both the 2M and 6M groups are mainly enriched in response to endoplasmic reticulum stress and the pancreatic secretion pathway. DEGs down-regulated in both the 2M and 6M groups are mainly enriched in the neuronal cell body and protein digestion and absorption pathway. Notably, along with the HFD feeding, mRNA expression of islet cell markers was significantly down-regulated, such as Ins1, Pdx1, MafA (β cell), Gcg, Arx (α cell), Sst (δcell), and Ppy (PP cell). In contrast, mRNA expression of acinar cell markers was remarkably up-regulated, such as Amy1, Prss2, and Pnlip. Besides, a large number of collagen genes were down-regulated, such as Col1a1, Col6a6, and Col9a2. Overall, our study provides a full-scale DEG map regarding HFD-induced islet dysfunction, which was helpful to understand the underlying molecular mechanism of islet deterioration further.
MAD‐DDS: Memory‐efficient automatic discovery data distribution service for large‐scale distributed control network
Authors: Nwadiugwu Williams‐Paul , Kim Dong‐Seong , Ejaz Waleed , Anpalagan Alagan 
Published: June 2023

AbstractThe rampant deployment of data distribution service (DDS) as middle‐ware service providers for industrial network platforms has been widely investigated. All DDS‐based node discovery protocols establish communication with its intended target systems by accessing matched endpoints/nodes information. These matched endpoints/nodes information is usually embedded with the system’s programmable control plane network which acts as the conveyor vehicle. The introduction of software defined networking (SDN) is to characterize the control plane from embedded data plane. The DDS implements the simple discovery protocol (SDP) as its inherent node discovery protocol. Deploying DDS for data packet exchange in server‐based collaborative distributed networked control (DNC) systems has gained traction. The current automatic discovery protocol (ADP) based on SDP is fraught with real‐time limitations such as high memory consumption and poor packet transmission. This work presents novel memory‐efficient automatic discovery data distribution service (MAD‐DDS) with enhanced threshold bloom filters (ETBF) where ETBF stores transmission packets at simulation end‐nodes. The packet is further adjusted using optimized binarization and decision thresholds inside ADP, hence guaranteeing memory reduction. The testbed computation recorded significantly improved quality of service (QoS) whereas numerical results depict significant decline in memory consumption with consistent packet transmission rates that produces increased computational capacity.
Transition von langzeitbeatmeten Kindern in die Erwachsenenmedizin
Authors: Wollinsky Kurt , Fuchs Hans , Schönhofer Bernd 
Published: June 2023

ZusammenfassungDurch die Fortschritte in der Langzeitbeatmung erreichen heutzutage viele Kinder mit chronisch respiratorischer Insuffizienz das Erwachsenenalter. Die medizinische Betreuung dieser Kinder muss deshalb von den Kinderärzten:innen zu den Erwachsenenärzten:innen übergehen. Dieser Prozess heißt „Transition“. Die Transition in die Erwachsenenmedizin dient v.a. der Förderung der Autonomie der heranwachsenden Jugendlichen und trägt den mit zunehmendem Alter eintretenden Änderung der Krankheitsbilder und der auftretenden Koerkrankungen Rechnung. Transition schafft aber auch Verunsicherung bei den Patienten und deren Eltern. Sie birgt die Gefahr des Verlustes des „Medical Home“ und sogar den Verlust der vollständigen medizinischen Versorgung. Gute strukturelle Voraussetzungen zur Bewältigung sind notwendig, genauso wie professionelle Vorbereitung der Patienten auf die Transition, durch Coaching der Patienten während der Umsetzung der Transition sowie eine formalisierte strukturierte Übergabe zwischen den Behandler:innen. Dieser Artikel zeigt auf, wie gute Transition funktionieren kann mit dem Fokus auf langzeitbeatmete Kinder.
Study on the Regulation of Trophoblast Activity by Abnormally Expressed lncRNA CCDC144NL-AS1 in Patients with Gestational Diabetes Mellitus
Authors: Cao Dan , Wang Yu 
Published: June 2023

AbstractGestational diabetes mellitus (GDM) is a common complication in pregnant women. The growth and differentiation of trophoblast cells determine the function of the placenta, and therefore further affect the transport of nutrients to the fetus. lncRNA Coiled-Coil Domain Containing 144 N-Terminal-Like antisense1 (CCDC144NL-AS1) was reported to be abnormally expressed in GDM, but its function and mechanism remain undefined. This study aimed to reveal the expression of CCDC144NL-AS1 in GDM and evaluate its significance in disease development. The expression of CCDC144NL-AS1 in serum and placenta tissues of GDM patients and healthy pregnant women was evaluated using PCR. The effect of CCDC144NL-AS1 on the proliferation, migration, and invasion of trophoblast cells was evaluated with CCK8 and Transwell assay. The mechanism of the interaction between CCDC144NL-AS1 and miR-143–3p was assessed by luciferase reporter assay and cell transfection. CCDC144NL-AS1 was upregulated in GDM patients, which discriminated GDM patients from healthy pregnant women with high sensitivity and specificity and was positively correlated with the insulin resistance indexes. In trophoblast cells, high glucose exposure induced increased CCDC144NL-AS1 and suppressed cell proliferation, migration, and invasion. Silencing CCDC144NL-AS1 could alleviate the inhibitory effect of high glucose, while the knockdown of miR-143–3p reversed the effect of CCDC144NL-AS1. In conclusion, upregulated CCDC144NL-AS1 served as a diagnostic biomarker of GDM and regulated the development of trophoblast cells via negatively modulating miR-143–3p.
Delays in Lung Cancer Diagnosis: Observations from a Tertiary Care Centre in Kerala, India
Authors: Yohannan Merin , Narayan Kiran Vishnu , Venugopal Kummannoor Parameswaran Pillai , Musthafa Sajitha 
Published: June 2023

Introduction Timely diagnosis of lung cancer is critical because treatment outcomes correspond to the stage of disease. This study identified patient and physician determined reasons for diagnostic delays.
Materials and Methods This was an observational cross-sectional study, conducted at a tertiary care institution in South India, for 12 months. From 207 consecutively selected patients, with a presumptive lung cancer diagnosis, 150 were enrolled utilizing a prefixed questionnaire. The time intervals from appreciation of initial respiratory symptoms to a final tissue diagnosis were defined sequentially as approach interval, referral interval, and diagnostic interval and factors causing delay in each interval were identified.
Results In a state with 100% literacy, the mean time to approach a doctor was 8 weeks (range: 0–336 days; SD: 7.95) with a delay seen in 52% of the study group. Referring a suspect lung cancer diagnosis to a specialist, took an average of 4.98 weeks (range: 1–26 weeks; SD: 5.64) with referral delays in 47.3% of patients. The mean diagnostic interval was 9.21 days (range: 3–41 days; SD: 7.18) and 16.7% of cases had diagnostic delays in spite of a definite procedure.
Conclusion In a tuberculosis endemic location, empirical treatment with anti-tuberculosis therapy and prolonged antibiotic courses without serially monitoring the course of disease are responsible for referral delays. Also, 88.2% of the total females studied, presented late due to family and work pressures, fear of being stigmatized and being on prolonged home remedies. A wider dissemination and awareness on lung cancer are needed especially among females. A low threshold to reinvestigate and an early referral to a pulmonary or lung cancer specialist, when expected clinicoradiological improvement is lacking, in microbiologically negative tuberculosis should be highlighted.
Estimation of Serum Leptin, Adiponectin, and Malondialdehyde Levels in Tobacco-Induced Oral Squamous Cell Carcinoma: ELISA-Based Study
Authors: Kamboj Mala , Sharma Gitika , Narwal Anjali , Gill Paramjeet S. , Devi Anju , Yadav Jagveer 
Published: June 2023

Background Tobacco, a harmful, addictive chemical is responsible for occurrence of oral cancer by triggering inflammation and lipid peroxidation. The aim of the present study is to explore if there exists any difference in serum levels of inflammatory biomarkers such as leptin, adiponectin, and lipid peroxidation marker malondialdehyde (MDA) and also its correlation with oxidative stress in cases of tobacco-induced oral squamous cell carcinoma (OSCC) as compared with tobacco users having no lesion.
Materials and Methods Enrolled participants in this study included a total of 84 subjects (all males and 28 in each group) inclusive of healthy individuals, tobacco users with no lesion, and oral cancer cases. Serum leptin, adiponectin, and MDA levels were measured via enzyme-linked immunosorbent assay method in all subjects.
Results A significant reduction in serum leptin and adiponectin levels in patients with OSCC was observed when compared with tobacco users with no lesions and healthy persons (control). For serum MDA, findings were comparable in control and tobacco consumers with no lesions groups but significantly higher in OSCC cases. The correlation between serum adiponectin, leptin, and MDA levels with body mass index (BMI) was highly significant. In addition, comparison of BMI with serum markers and histopathological grades of OSCC showed significant difference.
Conclusion These present study observations suggest that reduced adiponectin and leptin and elevated serum MDA could serve as valuable markers for both preventive and clinical intervention, and may deserve further investigation for the early diagnosis, treatment, and prognosis of OSCC.
Translating intercultural interactions in the Netflix-branded filmAmerican Factory
Authors: Hu Bei 
Published: June 2023

AbstractThe Netflix-branded filmAmerican Factoryglaringly illustrates China’s and the United States’s contrasting views on capitalism, propaganda, and labour rights. The film directors have argued that the entangling of clashing civilisations that permeates numerous layers of the documentary is delivered in a subtle and nuanced manner. However, the English and Chinese subtitles of the multilingual film’s bilingual dialogue are found to frequently, and usually implicitly, show varying levels of translator intervention that may alter the degree of cultural difference and opposition. By investigating the inherent translator interventions in the presentation of cultural allusions in Netflix’s English- and Chinese-translated subtitles of the bilingual dialogue in the film, this study focuses on the extent to which these interventions are discursively juxtaposed with Netflix’s media logic. Special attention is paid to how intercultural positions are perceived by heterogeneous viewers in China and the United States. This article argues that streaming media giants, such as Netflix, exert an influence on the representation of cultural nuances in multilingual films. Hence, the study calls for a reflexive view of streaming media translation research that acknowledges the complex power dynamics resulting from audio-visual intercultural communication and its corresponding implications for intercultural relations.
DFT-based investigation of electronic-structure, magnetic and thermoelectric properties of Dy2CoMnO6 double perovskite
Authors: Essaoud Saber Saad , Azar Said M , Mousa Ahmad A , Al-Reyahi Anas Y 
Published: June 2023

Abstract
The density functional theory as a computational approach was used to explore the ferrimagnetic semiconducting behavior of Dy2CoMnO6 double perovskite compound in both spin-up and spin-down directions. Thermodynamic stability was confirmed in a wide pressure range set to 30 GPa. Both scalar and full relativistic calculations are used to estimate the spin–orbit effect. The topological distribution of the charge density and the net effective charge of each atom are studied based on the Quantum Theory of Atoms in Molecules (QTAIM) as implemented in Bader code, Besides this, the different QTAIM atomic basins descriptors such as electron density

ρ

b

,

Laplacian of the electron density

∇

2

ρ

b

,

potential electronic energy density

V

b

,

kinetic electronic energy density

G

b

and density of the total electronic energy

H

b

at bond critical points (BCPs) are estimated using CRITIC2 software where the ionic type for Dy-O, Co-O, and Mn-O bonds are evaluated. Holes and electrons have different effective masses, their thermoelectric properties appear high figure of merit (ZT) exceeding 0.5 for temperatures greater than 500 K in the negative chemical potential region, suggesting that doping with holes might be more favorable for thermoelectric efficiency than doping with electrons.
DFT study of structural optoelectronic and thermoelectric properties of CuNiO ferromagnetic alloys
Authors: Gandouzi Mohamed , Alshammari Abdullah S , Bouzidi M , Khan Z R , Mohamed Mansour , Ben Nasrallah Tarek 
Published: June 2023

Abstract
In this study, the structural, electronic, and thermoelectric properties of pure NiO and Cu-doped NiO were investigated. The structural and optoelectronic properties of nickel oxide and in the supercell containing

32

atoms CuNi15O16 were obtained by density functional theory (DFT) using the generalized gradient approximation (GGA) with the Hubbard correction potential U. The theoretical results obtained using the quantum espresso code show that the ferromagnetic character of the supercell structure is more stable than the antiferromagnetic configuration, and incorporating copper in the NiO matrix reduces the spin-up band structure. The value of the band gap channel is approximately 1.7 eV. The spin-down states cross the Fermi level and indicate the half-metal character of the CuNiO alloys. These results suggest that Cu-doped NiO is a potential candidate for infrared light and spintronic applications. The transport coefficients of the nickel oxide and copper doped NiO were calculated using the semi-classical Boltzmann theory implemented in BoltzTraP code. The thermoelectric properties, such as the Seebeck coefficient, power factor, and figure of merit, are calculated with respect to the chemical potential and carrier concentration in the temperature range of 300 K–800 K. We found an increase in the factor of merit and switching of NiO oxide from n-type to p-type after copper incorporation.