bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’exception franco-canadienne dans deux romans ethnographiques québécois
Authors: Brun del Re Ariane 
Published: June 2023

Cet article cherche à dégager les principales caractéristiques du roman ethnographique québécois explorant la francophonie canadienne en procédant à l’analyse comparative de La maudite Québécoise. Roman nationaliste (Tryptique, 2010) de Janis Locas et Yukonnaise (VLB Éditeur, 2012) de Mylène Gilbert-Dumas. Ces deux romans mettent en scène des protagonistes québécoises qui découvrent la francophonie manitobaine ou yukonnaise. Persuadées de tenir un sujet exceptionnel, elles s’improvisent ethnographes et décident de faire part de leur « découverte » dans un livre qui raconte les différences entre le Québec et la francophonie canadienne. Tout en s’interrogeant sur la perception que les Québécois et les Québécoises entretiennent des francophones en situation minoritaire et vice-versa, Locas et de Gilbert-Dumas proposent des pistes d’intégration à l’intention de leur public cible, le lectorat québécois.
Estado de Derecho y Democracia: equilibrio contramayoritario frente a efectos autoritarios de la polarización
Authors: Rivero Ortega Ricardo 
Published: June 2023

La Democracia y el Estado de Derecho son principios constitucionales complementarios, no realizables por separado. Una crítica constructiva sobre déficits es aceptable, pero la afirmación de su fracaso amenaza la legitimidad de instituciones imprescindibles para la convivencia social. Las aproximaciones académicas que enfrentan dialécticamente gobierno democrático y respeto de las normas favorecen reacciones autoritarias de signo extremista, en un marco de polarización social creciente y riesgo de quiebra de la Democracia. Por ello, los juristas debemos aportar soluciones, así como mostrar audacia y coraje en la defensa de los valores fundamentales. También debemos recordar que los equilibrios contramayoritarios compensan el riesgo de efectos autoritarios de la polarización.
González Ordovás, María José. Derechos versus democracia. Ironía de la globalización. Valencia: Tirant lo Blanch, 2022.
Authors: Pérez Jaraba Mª Dolores 
Published: June 2023

Resensión de: González Ordovás, María José. Derechos versus democracia. Ironía de la globalización. Valencia: Tirant lo Blanch, 2022.
de Prada García, Aurelio. El proceso de Sócrates: del ‘nosotros’ al ‘yo’. Contra el prejuicio individualista no percibido. Madrid: Ápeiron, Faber & Sapiens, 2022.
Authors: Muñoz de Baena José Luis 
Published: June 2023

Recensión de: de Prada García, Aurelio. El proceso de Sócrates: del ‘nosotros’ al ‘yo’. Contra el prejuicio individualista no percibido. Madrid: Ápeiron, Faber & Sapiens, 2022.
In silico Study of Ornithine Decarboxylase and HSP-90 Gene in the Anti-trypanosomal Activities of Annona muricata Annonaceae
Authors: Osho Innocent Bamidele , Adebayo Isaac Abayomi , Elekofehinti Olusola Olalekan , Durojaye Catherine Olusunmibola 
Published: June 2023

Aims: Trypanosomiasis is one of the neglected tropical diseases of Sub-Saharan Africa caused by the numerous species and sub-species of the protozoan genus Trypanosoma. Soursop, also known as Annona muricata (Annonaceae), is a prevalent tropical plant species renowned for its numerous medicinal properties, including the treatment of protozoan infections. The fundamental mechanism of anti-trypanosomal effects of A. muricata was investigated using ornithine decarboxylase and HSP-90, which are validated potential drug targets.
Place and Duration of Study: Animal Parasitology and Microbiology Research Unit, Department of Animal Production and Health, Federal University of Technology, Akure, Nigeria, between March and October 2022.
Methodology: The interaction of compounds previously characterized from A. muricata was investigated against Ornithine decarboxylase and HSP-90 genes of Trypanosoma brucei brucei using Autodock Vina.
Results: Based on their binding affinity and binding free energy, eight compounds (rutin, kaempferol 3-O-rutinoside, annomuricinA, murihexocin B, muricatocin A, acetogenin, asimilobine, and gigantetrocin A) out of the 160 compounds screened were found to be effective against Trypanosoma brucei brucei. The hit molecules were further screened for ADME profiles. Acetogenin and asimilobine were considered the ideal drug candidates because they showed moderation for ADME properties and obeyed Lipinski’s rule of five.
Conclusion: This study confirmed the use of Annona muricata in the treatment of trypanosomosis and the probable compounds responsible for its antitrypanosomal effect are acetogenin and asimilobine which acts at the HSP-90 genes of the parasite Trypanosoma brucei brucei.
Camrelizumab Plus Apatinib and Temozolomide as First-Line Treatment in Patients With Advanced Acral Melanoma
Authors: Mao Lili , Lian Bin , Li Caili , Bai Xue , Zhou Li , Cui Chuanliang , Chi Zhihong , Sheng Xinan , Wang Xuan , Tang Bixia , Yan Xieqiao , Li Siming , Kong Yan , Dai Jie , Wei Xiaoting , Li Juan , Duan Rong , Xu Huayan , Wu Xiaowen , Yang Yue , Cheng Fengzhuo , Zhang Cheng , Xia Fangzhou , Pang Zheng , Guo Jun , Si Lu 
Published: June 2023

ImportanceAcral melanoma, known for low tumor mutation burden, responds poorly to immunotherapy. A standard therapy is still lacking.ObjectiveTo investigate the activity and safety of camrelizumab (an anti–programmed cell death-1 antibody) plus apatinib (a vascular endothelial growth factor receptor 2 inhibitor) and temozolomide as first-line treatment in patients with advanced acral melanoma.Design, Setting, and ParticipantsIn this single-arm, single-center, phase 2 nonrandomized clinical trial, patients with treatment-naive unresectable stage III or IV acral melanoma were enrolled at Peking University Cancer Hospital and Institute between June 4, 2020, and August 24, 2021. The data cutoff date was April 10, 2022.InterventionsPatients received 4-week cycles of intravenous camrelizumab, 200 mg, every 2 weeks; oral apatinib 250 mg, once daily; and intravenous temozolomide, 200 mg/m2, once daily on days 1 to 5 until disease progression or unacceptable toxic effects.Main Outcomes and MeasuresThe primary end point was objective response rate as assessed by investigators according to the Response Evaluation Criteria In Solid Tumors (version 1.1). Secondary end points included progression-free survival, time to response, duration of response, disease control rate, overall survival, and safety.ResultsA total of 50 patients (32 men [64%]; median age, 57 years [IQR, 52-62 years]) were enrolled and received treatment. The median follow-up duration was 13.4 months (IQR, 9.6-16.2 months). The objective response rate was 64.0% (32 of 50; 95% CI, 49.2%-77.1%). The median time to response and duration of response were 2.7 months (IQR, 0.9-2.9 months) and 17.5 months (95% CI, 12.0 to not reached), respectively. The disease control rate was 88.0% (44 of 50; 95% CI, 75.7%-95.5%). The estimated median progression-free survival was 18.4 months (95% CI, 10.6 to not reached). The median overall survival was not reached. The most common grade 3 or 4 treatment-related adverse events were increased gamma-glutamyltransferase levels (15 [30%]), decreased neutrophil count (11 [22%]), increased conjugated bilirubin levels (10 [20%]), and increased aspartate aminotransferase levels (10 [20%]). No treatment-related deaths occurred.Conclusions and RelevanceThe findings of this nonrandomized clinical trial suggest that camrelizumab plus apatinib and temozolomide may be a potential first-line treatment option for patients with advanced acral melanoma, which warrants further validation in a randomized clinical trial.Trial RegistrationClinicalTrials.gov Identifier: NCT04397770
Improvement of deep learning prediction model in patient‐specific QA for VMAT with MLC leaf position map and patient's dose distribution
Authors: Tozuka Ryota , Kadoya Noriyuki , Tomori Seiji , Kimura Yuto , Kajikawa Tomohiro , Sugai Yuto , Xiao Yushan , Jingu Keiichi 
Published: June 2023

AbstractPurposeDeep learning‐based virtual patient‐specific quality assurance (QA) is a novel technique that enables patient QA without measurement. However, this method could be improved by further evaluating the optimal data to be used as input. Therefore, a deep learning‐based model that uses multileaf collimator (MLC) information per control point and dose distribution in patient's CT as inputs was developed.MethodsOverall, 96 volumetric‐modulated arc therapy plans generated for prostate cancer treatment were used. We developed a model (Model 1) that can predict measurement‐based gamma passing rate (GPR) for a treatment plan using data stored as a map reflecting the MLC leaf position at each control point (MLPM) and data of the dose distribution in patient's CT as inputs. The evaluation of the model was based on the mean absolute error (MAE) and Pearson's correlation coefficient (r) between the measured and predicted GPR. For comparison, we also analyzed models trained with the dose distribution in patient's CT alone (Model 2) and with dose distributions recalculated on a virtual phantom CT (Model 3).ResultsAt the 2%/2 mm criterion, MAE[%] and r for Model 1, Model 2, and Model 3 were 2.32% ± 0.43% and 0.54 ± 0.03, 2.70% ± 0.26%, and 0.32 ± 0.08, and 2.96% ± 0.23% and 0.24 ± 0.22, respectively; at the 3%/3 mm criterion, these values were 1.25% ± 0.05% and 0.36 ± 0.18, 1.57% ± 0.35% and 0.19 ± 0.20, and 1.39% ± 0.32% and 0.17 ± 0.22, respectively. This result showed that Model 1 exhibited the lowest MAE and highest r at both criteria of 2%/2 mm and 3%3 mm.ConclusionsThese findings showed that a model that combines the MLPM and dose distribution in patient's CT exhibited a better GPR prediction performance compared with the other two studied models.
Retraction: Phosphorus‐Rich Colloidal Cobalt Diphosphide (CoP2) Nanocrystals for Electrochemical and Photoelectrochemical Hydrogen Evolution
Authors: Li Hui , Wen Peng , Itanze Dominique S. , Kim Michael W. , Adhikari Shiba , Lu Chang , Jiang Lin , Qiu Yejun , Geyer Scott M. 
Published: June 2023

Adv. Mater. 2019, 31, 1900813.https://doi.org/10.1002/adma.201900813The above article, published online on May 6, 2019, in Wiley Online Library (https://doi.org/10.1002/adma.201900813), has been retracted by agreement between the authors, the journal Editor in Chief Jos Lenders, and Wiley‐VCH GmbH. The retraction has been agreed on following concerns raised by a third party and a subsequent investigation at Wake Forest University. Data integrity issues were found in Figures 2c, 4d, S13a, S13b, S15, and S37. As a result, the authors consider the conclusions of this article invalid.
Single Non‐Blinking Graphene Quantum Dots Identified by Single‐Particle Catalysis
Authors: Fu Wei , Cao Huaqiang , Cheetham Anthony K. 
Published: June 2023

AbstractQuantum dots (QDs) with non‐blinking applied in bio‐imaging is important for understanding cellular dynamics by monitoring single particles in living cells. Antibunching is once believed to be applied to identify a single QD, which shows a strong dependence on the atom or ion number. However, recent works indicate that the antibunching alone may not be sufficient to demonstrate that the fluorescence comes from a single QD. To some extent, it is neither necessary nor sufficient for a single QD, though it is absolutely right for a single atom because a single QD is composed of thousands of atoms, which in principle are favorable to the formation of multi‐excitonic states. Blinking behavior, almost unobservable in ensembles due to the averaging, is characteristic of the single QD which owns the quantum effect due to its discrete energy levels. Here, a method of transformation of a single graphene quantum dot from non‐blinking to blinking via catalytic reaction to identify a single QD is reported, which can also help with understanding the catalytic dynamics of a single QD, which is a complementary means of confirming a single QD. The reported technique paves the way to understanding a single QD and its catalytic and kinetic behaviors.
Can we eliminate the primate pet trade in the United States?
Authors: Norconk Marilyn A. , Atsalis Sylvia , Savage Anne 
Published: June 2023

AbstractInternational laws and conventions have gone a long way in reducing the number of wild primates entering the United States of America (US) for the pet trade. However, breeding primates for sale to private owners in the United States continues, and individual states present a bewildering array of laws and regulations on the holding of primates as pets. As primatologists we can act to decrease the demand for primate pets by (1) speaking out on the inappropriate use of primates in mass media and especially in social media; (2) not posing in photographs in close proximity to primates; (3) continuing to educate about why primates do not make good pets; and (4) contributing to the science that underlies state and federal legislation with the goal of eliminating captive breeding of primates for the pet trade. We encourage primatologists and others in related fields to be cognizant of the persistent commercialization of primates and be willing to take action to deter it.
Tranexamic acid in endoscopic sinus and skull base surgery: A systematic review and meta‐analysis
Authors: Abdallah Zahra , Staibano Phillip , Zhou Kelvin , Khalife Sarah , Nguyen Thomas B. V. , Sommer Doron D. 
Published: June 2023

AbstractObjectiveEndoscopic sinus surgery (ESS) and endoscopic skull base surgery (ESBS) approaches have revolutionized the management of sinonasal and intracranial pathology. Maintaining surgical hemostasis is essential as bleeding can obscure the visibility of the surgical field, thus increasing surgical duration, risk of complications, and procedural failure. Tranexamic acid (TXA) acts to reduce bleeding by inhibiting fibrin degradation. This review aims to assess whether TXA improves surgical field quality and reduces intraoperative blood loss compared with control.MethodsWe searched PubMed, MEDLINE, Embase, Web of Science, and Cochrane Library from inception until September 1, 2022. Two reviewers independently screened citations, extracted data, and assessed methodological quality using the Cochrane risk‐of‐bias tool for randomized trials. Data were pooled using a random‐effect model, with continuous data presented as mean differences and dichotomous data presented as odds ratios.ResultsSeventeen ESS randomized controlled trials (n = 1377) and one ESBS randomized controlled trial (n = 50) were reviewed. Significant improvement in surgical field quality was achieved with both systemic TXA (six studies, p < 0.00001) and topical TXA (six studies, p = 0.01) compared with the control. Systemic TXA (eight studies) and topical TXA (three studies) both achieved a significant reduction in intraoperative blood loss compared with the control (p < 0.00001). There were significant differences in operative times (p < 0.001) but no significant difference in perioperative outcomes (p = 0.30).ConclusionThis meta‐analysis demonstrated that the administration of TXA in ESS can improve surgical field quality and reduce intraoperative blood loss. TXA use did not result in increased perioperative complications including thrombotic events.
Cardiac arrest following sugammadex administration
Authors: Pereira A. V. , Oliveira R. R. , Esteves C. , Coutinho M. A. 
Published: June 2023

SummaryA 68‐year‐old man underwent elective surgical repair of an abdominal wall hernia under general anaesthesia. The operation required muscle relaxation, for which we used rocuronium. Following completion of surgery, 180 mg sugammadex was administered intravenously. Shortly afterwards, the patient became severely bradycardic with hypotension, refractory to treatment with ephedrine. This progressed to a pulseless electrical activity cardiac arrest. After 4 min of cardiopulmonary resuscitation, there was return of spontaneous circulation and, following a period of haemodynamic stability in which general anaesthesia was maintained, the patient emerged from anaesthesia without incident. He remained haemodynamically stable until discharge. Post‐resuscitation investigations including the serum tryptase level were unremarkable except for a mild respiratory acidosis and slightly elevated D‐dimers. Sugammadex‐induced bradycardia has previously been described, but its mechanism remains unknown. We believe that sugammadex was the cause of cardiac arrest in this case because of the timing and sequence of events, the evolution to pulseless electric activity and the relatively uneventful post‐arrest clinical course. We hope that our report will help to promote awareness about this potential complication of a now commonly‐used drug.
Preparation of high‐performance polyurethane elastomers via direct use of alcoholyzed waste PET by high molecular weight polyester diols
Authors: Liu Li , Hao Panpan , Zhang Ruiqi , Zhang Yujin , Zhou Qing , Lu Xingmei , Yan Dongxia , Li Yi , Shi Chunyan 
Published: June 2023

AbstractProducts obtained by alcoholysis of waste PET are promising raw materials for the synthesis of polyurethane elastomers (PUEs). Alcoholysis of PET by low molecular weight diols such as ethylene glycol yields low molecular weight products. The latter need to be polymerized to high molecular weight polyols which are subsequently used as soft segments for the synthesis of PUEs. This work aims to look for suitable high molecular weight diols for the alcoholysis of waste PET to yield high molecular weight products which can be directly used as soft segments for the synthesis of PUEs. This approach allows to save the polymerization step for the formation of high molecular weight polyols. Specifically, polyester diols such as polycaprolactone diol (Mn = 2000) were used for the alcoholysis of waste PET. The resulting PUEs exhibited very good mechanical properties: a tensile strength of up to 40.95 MPa, an elongation at break of up to 1219%, and a toughness of up to 237 MJ·m−3, along with good transparency and thermal stability.
In situ evaluation of alginate‐Ca2+ gelation kinetics
Authors: Besiri Ioanna N. , Goudoulas Thomas B. , Fattahi Ehsan , Becker Thomas 
Published: June 2023

AbstractA thorough assessment of gelation progress requires real‐time recording of biopolymer kinetics. In this study, an in situ investigation with a customized parallel‐plate rheometric setup examines how the initial distribution of CaCl2 to alginate through micro‐holes affects the process. At constant volume and concentration of reactants, stiffer gels are produced at the same probing time by increasing the number of suppliers (2–12). Due to the oscillation and the different local distribution of the cations into the biopolymer solution, the development of gel front is affected, which is for the first time in situ rheologically investigated by the temporal evaluation of complex modulus, G*. The alternative configurations of the same number of micro‐holes have drastically contribution to this regard, too. Moreover, a two‐kernel equation is introduced predicting the alginate‐Ca2+ gelation kinetics. It represents the initial fast increase in G*, determined by the concentration of cross‐linker, and the slow diffusion of cations to the assembled gelling structures depicted on the successive evolution of G* in longer times. Finally, a continuous and an intermittent oscillatory time sweep influence the diffusion of the cross‐linking solution resulting in considerably different gelation curves for the same concentration of reactants.
Protected land enhances the survival of native aquatic macrophytes and limits invasive species spread in the Panama Canal
Authors: Salgado Jorge , Vélez María I. , González‐Arango Catalina , O'Dea Aaron 
Published: June 2023

Abstract

This study examined whether protected land in a tropical reservoir's catchment can promote the survival of native aquatic plants (macrophytes) and limit the spread of invasive alien plant species (macrophyte IAS), which can threaten native wildlife and require expensive remediation. As the number of tropical river dams is expected to increase in the coming decades to meet societal demands, it is crucial to explore solutions for preserving aquatic biodiversity.
The study used a before–after–control–intervention design, based on monitoring data and long‐term sedimentological, climatic and ecological records from both lake and river zones adjacent to protected and unprotected lands around the 100‐year‐old Gatun Lake in the Panama Canal, Panama. The research examined the impact of impoundment and the invasion of Pontederia crassipes (water hyacinth) and Hydrilla verticillata (water thyme) on native macrophyte communities and environmental variables.
Lake zones adjacent to protected lands had lower nutrient concentrations, greater variations in water depth profiles and reduced fluctuations in water chemistry than lake zones outside areas of land protection. In addition, the results showed that whereas zones adjacent to unprotected land became dominated by macrophyte IAS, lake zones adjacent to protected areas were more resilient to the spread of macrophyte IAS and were able to maintain viable populations of native pre‐dam species for >100 years.
This study indicates that protecting land adjacent to tropical reservoirs could be a cost‐effective solution for preserving aquatic macrophyte biodiversity by retaining nutrients, stabilizing water chemistry, providing habitat heterogeneity and protecting native vegetation, while still supporting terrestrial conservation goals. These findings could aid in planning measures for the hundreds of proposed dam projects across lowland tropical areas and provide new insights into best practices for enhancing river ecosystem resilience.
Recent Progress in Polyethylene‐enhanced Organic Phase Change Composite Materials for Energy Management
Authors: Wu Wen‐Ya , Yeo George Ming Da , Wang Suxi , Liu Zhiyuan , Loh Xian Jun , Zhu Qiang 
Published: June 2023

AbstractPhase Change Materials (PCMs) are utilized to regulate temperature and store thermal energy in various industries such as infrastructure, electronics, solar power, and more. However, they face several limitations, such as leakage, poor thermal properties, incompatibility, as well as high flammability. Polyethylene (PE) is one of many polymers explored to enhance the desirable properties of PCMs, due to their versatile properties such as high strength, durability, chemical resistance, and low cost. The combination of PCMs and PE can be used to create composite materials, through micro/nano‐ encapsulation, melt‐blending, formation of composites and with proper additives. They create enhanced thermal energy storage properties and in the meantime, benefited from the mechanical properties of the PE. This review provides a concise summary of the recent developments regarding PE‐enhanced PCMs and provides insights into possible topics for further investigation. We summarised enhancement methods based on commonly adopted types of PEs, such as encapsulation, melt‐blending, hot pressing, extrusion, and 3D printing. We then elaborate on how these PE‐PCM composites are effectively utilised for heat management applications and the potential future directions in energy‐saving buildings, electronic devices, and energy storage systems.