bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shock drives a STAT3 and JunB-mediated coordinated transcriptional and DNA methylation response in the endothelium
Authors: Ramos Ramon Bossardi , Martino Nina , Chuy Dareen , Lu Shuhan , Zuo Mei Xing G. , Balasubramanian Uma , Di John Portela Iria , Vincent Peter A. , Adam Alejandro P. 
Published: September 2023

ABSTRACT
Endothelial dysfunction is a crucial factor in promoting organ failure during septic shock. However, the underlying mechanisms are unknown. Here, we show that kidney injury after lipopolysaccharide (LPS) insult leads to strong endothelial transcriptional and epigenetic responses. Furthermore, SOCS3 loss leads to an aggravation of the responses, demonstrating a causal role for the STAT3-SOCS3 signaling axis in the acute endothelial response to LPS. Experiments in cultured endothelial cells demonstrate that IL-6 mediates this response. Furthermore, bioinformatics analysis of in vivo and in vitro transcriptomics and epigenetics suggests a role for STAT, AP1 and interferon regulatory family (IRF) transcription factors. Knockdown of STAT3 or the AP1 member JunB partially prevents the changes in gene expression, demonstrating a role for these transcription factors. In conclusion, endothelial cells respond with a coordinated response that depends on overactivated IL-6 signaling via STAT3, JunB and possibly other transcription factors. Our findings provide evidence for a critical role of IL-6 signaling in regulating shock-induced epigenetic changes and sustained endothelial activation, offering a new therapeutic target to limit vascular dysfunction.
Putting a new spin on insect jumping performance using 3D modeling and computer simulations of spotted lanternfly nymphs
Authors: Li Chengpei , Xu Aaron J. , Beery Eric , Hsieh S. Tonia , Kane Suzanne Amador 
Published: September 2023

ABSTRACT
How animals jump and land on diverse surfaces is ecologically important and relevant to bioinspired robotics. Here, we describe the jumping biomechanics of the planthopper Lycorma delicatula (spotted lanternfly), an invasive insect in the USA that jumps frequently for dispersal, locomotion and predator evasion. High-speed video was used to analyze jumping by spotted lanternfly nymphs from take-off to impact on compliant surfaces. These insects used rapid hindleg extensions to achieve high take-off speeds (2.7–3.4 m s−1) and accelerations (800–1000 m s−2), with mid-air trajectories consistent with ballistic motion without drag forces or steering. Despite rotating rapidly (5–45 Hz) about time-varying axes of rotation, they landed successfully in 58.9% of trials. They also attained the most successful impact orientation significantly more often than predicted by chance, consistent with their using attitude control. Notably, these insects were able to land successfully when impacting surfaces at all angles, pointing to the importance of collisional recovery behaviors. To further understand their rotational dynamics, we created realistic 3D rendered models of spotted lanternflies and used them to compute their mechanical properties during jumping. Computer simulations based on these models and drag torques estimated from fits to tracked data successfully predicted several features of the measured rotational kinematics. This analysis showed that the rotational inertia of spotted lanternfly nymphs is predominantly due to their legs, enabling them to use posture changes as well as drag torque to control their angular velocity, and hence their orientation, thereby facilitating predominately successful landings when jumping.
Catalyst Design with Small Organic Ion Pairs
Authors: Ohmatsu Kohsuke 
Published: September 2023

Abstract
Cations and anions are fundamental species whose interactions have been thoroughly studied and widely applied in organic synthesis, particularly to control the selectivity in chemical transformations. Strategies exploiting ion pairing have proven to be applicable to a broad range of reactions that proceed via anionic intermediates and cationic species. Considering the general versatility of ion pairs in constructing well-organized transition structures, we utilized these powerful attractive interactions to construct catalyst structures. This account summarizes the design and applications of ion-paired chiral ligands and chiral 1,2,3-triazolium salts.
Characterization of By-products with High Fat Content Derived from the Production of Bovine Gelatin
Authors: Garcia Londoño Victor Alonso , Marín González Natalia , Roa-Acosta Diego Fernando , Agudelo Laverde Lina Marcela , Botero Laura , Lellesch Liliana Maria 
Published: September 2023

Background: Gelatin is a protein obtained by partial hydrolysis of collagen contained in skins, connective tissue and/or animal bones, which are by-products of the meat industry. The main raw material to produce bovine gelatin is the dermis of the skin, but there is a variation in fat and moisture content depending on the bovine skin origin. As a contribution to the circular economy and sustainability, these by-products with high fat content and the fat released from them during the gelatin production process can be managed for food industries, mainly in the development or formulation of animal feed. Methods: For the initial physicochemical characterization, moisture, fat, protein and ashes content were determined. Once the by-products with high fat content were identified, alteration parameters such as acidity, peroxide and saponification indexes were evaluated. Additionally, thermal, rheological and fatty acid composition characterization was carried out in order to study the possible applications of the by-products. Results and Discussion: The results showed that certain by-products have a fat content of less than 15%, so the viability of their use is limited. On the other hand, some by-products have a fat content exceeding 30%; however, their extraction can only be done manually, resulting in a low efficiency process. By-products removed from the supernatant in the extractors presented fat percentages of 99.9 and 98.9%, and there exists the possibility of implementing a mechanical method for their extraction. The analysis of alteration and oxidation parameters, thermal and rheological characterization, fatty acid profile and solid fat content were exclusively conducted on these high-fat content by-products. Based on the characterization, these by-products could be valued and incorporated into animal feed formulations. Nevertheless, certain limitations exist for their use in applications such as biodiesel production or the food industry.
'I-know-it-when-I-see-it' - Motivating Examples in the Social Psychology of Conspiracy Theory Theory
Authors: Dentith M R. X. 
Published: September 2023

Looking at set of 76 representative articles published by social psychologists between 2017 and 2023 (reviewed between December 2022 and February 2023), I examine the role of motivating examples---a kind of illustrative example, typically used by researchers at the beginning of their work to motivate the issue or problem they want to resolve or address in that work---in the social psychological work on conspiracy theory. Through an examination of the language around how motivating examples are introduced and used in the social psychological literature, I argue that the abstract and vague way that social psychologists employ such examples ends up relying on what Joseph Uscinski and Adam Enders deem as an unviable and easily abused `I-know-it-when-I-see-it' standard. As will be demonstrated, much of the recent work in the social psychology of conspiracy theory assumes and thus fails to establish what is supposedly problematic about belief in the conspiracy theories used as motivating examples. As a consequence the surveyed work typically fails to adequately capture belief in actual conspiracy theories, let alone establish a case for a general suspicion of such beliefs. This work, then, adds to and extends upon existing critiques of the social psychology of conspiracy theory by members of the wider community of scholars studying conspiracy theories. The upshot of this research is that if social psychologists want their work to be of use to the broader scholarly community studying these things called `conspiracy theories', then they need to connect their work on the problems of conspiracy beliefs or mindsets to concrete examples of belief in unwarranted conspiracy theories.
Gastrointestinal disorders and leaky gut syndrome in endurance athletes
Authors: Murawiec Izabela , Konert Magdalena 
Published: September 2023

Gastrointestinal disorders are common in endurance-sport athletes, and can negatively affect physical performance and general health. During long lasting exercises such like ultramarathon, triathlon, marathon a characteristic phenomenon is the increase in the concentration many proinflammatory markers and proteins such like IL-1, IL-6, TNF-alfa, LPS, CK and C-reactive protein. Despite observed biochemical changes on of the typical “side effects” of physical activity is increased intestinal permeability, also called to as leaky gut.
Recent research has demonstrated that even one hour of of intense endurance training note even with a maximum work capacity can lead to leaky gut symptoms and gastrointestinal disorders.
Increased intestinal permeability is accomplished with changes of numerus molecular biomarkers, that indicate presence of this disease state and the degradation of the intestinal mucosa, such like lipopolysaccharides, zonulin, lactulose/rhamnose ratio, occludin and I-FABP, and many other.
The understanding of this processes and understanding of the molecular mechanisms involved in the induction of leaky gut syndrome can lead to funding new methods and means of both avoiding and treating this condition.
Aberration budget analysis of EUV lithography from the imaging performance of a contact layer in a 5  nm technology node
Authors: Chen Zhishu , Dong Lisong , Ding Huwen , Wei Yayi 
Published: September 2023

By analyzing the impact of aberration in an extreme ultraviolet
lithography projector on the imaging indicators of the test patterns
for a contact layer in a 5 nm technology node, this paper
establishes a mathematical aberration model based on the back
propagating neutral network. On the basis of an aberration model, a
method for estimating the aberration budget is proposed, which can
help reduce the difficulty of achieving imaging performance thresholds
in actual production. The performance of the results given by this
method is verified by using a rigorous simulation. The results show
that the model is highly accurate in predicting an aberration
distribution that meets the requirements through an inverse
sensitivity analysis and can calculate the wavefront aberration margin
based on imaging indicators.
Semi-embedded slot waveguide electro-optic modulator
Authors: Li Renjie , Chen Ming , Shi Xinyu , Han Wenhao , Wang Xiangyang , Zhao Wanli , Liu Jinbiao , Teng Chuanxin , Deng Shijie , Cheng Yu , Yuan Libo 
Published: September 2023

Electro-optic modulators are essential devices on silicon photonic chips in modern
optical communication networks. This paper presents a compact,
low-loss electro-optic modulator. The modulation efficiency is greatly
improved by embedding the lower half of the slot waveguide into the
buried oxide layer and inserting graphene at the junction. The
interaction of graphene with an optical field in a waveguide is
studied using the finite element method. The functions of phase
modulation and absorption modulation are realized by changing the gate
voltage to change the chemical potential of graphene. The
semi-embedded slot waveguide optical modulator has a length of
50 µm. After simulation verification, it can be used as an
electro-absorption modulator and can achieve a modulation depth of
26.38 dB and an insertion loss of 0.60 dB. When used as
an electro-refractive modulator, it can be realized with a linear
change of phase from zero to π; the total insertion loss is only
0.59 dB. The modulator has a modulation bandwidth of
79.6 GHz, and the energy consumption as electro-absorption and
electro-refraction modulation are 0.51 and 1.92 pj/bit,
respectively. Compared with common electro-optic modulators, the
electro-optic modulator designed in this paper has a higher modulation
effect and also takes into account the advantages of low insertion
loss and low energy consumption. This research is helpful for the
design of higher-performance optical communication network
devices.
High Q-factor, ultrasensitivity slot microring resonator sensor based on chalcogenide glasses: erratum
Authors: Zhang Xuelei , Zhou Chenfeng , Luo Ye , Yang Zhen , Zhang Wei , Li Lan , Xu Peipeng , Zhang Peiqing , Xu Tiefeng 
Published: September 2023

We correct the error in [Opt. Express 30, 3866 (2022)10.1364/OE.450092], Fig. 6(c). The unit of the vertical axis in the figure should be arbitrary units, not dB. All the conclusions are unchanged after the correction.
Arbitrary terahertz chirality construction and flexible manipulation enabled by anisotropic liquid crystal coupled chiral metasurfaces
Authors: Jiang Xinhao , Ji Yunyun , Fan Fei , Jiang Songlin , Tan Zhiyu , Zhao Huijun , Cheng Jierong , Chang Shengjiang 
Published: September 2023

Chiral metasurfaces integrated with active materials can dynamically control the chirality of electromagnetic waves, making them highly significant in physics, chemistry, and biology. Herein, we theoretically proposed a general and feasible design scheme to develop a chiral metadevice based on a bilayer anisotropic metasurface and a monolayer liquid crystal (LC), which can construct and flexibly manipulate arbitrary terahertz (THz) chirality. When the twist angle between the anisotropic axes of two metasurfaces θ is not 0°, the spatial mirror symmetry of the chiral metadevice is broken, resulting in a strong THz chiral response. In addition, the introduction of anisotropic LCs not only enhances the chiral response of the metadevice but also induces the flipping modulation and frequency tunability of the chirality. More importantly, by optimizing the θ, we can flexibly design the arbitrary chiral response and the operating frequency of chirality, thereby promoting the emergence of various chiral manipulation devices. The experimental results show that the maximum circular dichroism can reach −33  dB at 0.94 THz and flip to 28 dB at 0.69 THz by rotating the LC optical axis from the x to y axis, with the maximum operating frequency tunable range of ∼120  GHz. We expect this design strategy can create new possibilities for the advancement of active THz chiral devices and their applications, including chiral spectroscopy, molecular recognition, biosensing, and fingerprint detection.
Strong Photon-Magnon Coupling in the Metasurface Based on a System of Coupled Anapole Resonators
Authors: Girich A.A. , Polevoy S.Yu. , Tarapov S.I. , Vakula A.S. , Nedukh S.V. , Sova K. Yu. 
Published: September 2023

We have numerically investigated the photon-magnon coupling in the system of coupled anapole resonators (metasurface). A strong spin-number-normalized coupling strength (single spin-photon coupling)
g
e
f
f
/2πN was reached up to 0.276 Hz (g
eff
/2π = 310 MHz) at a frequency of 9.7 GHz compared to the spin-number-normalized coupling strength in a single splitring resonator (SRR)
g
e
f
f
/2πN=0.097 Hz(g
e
f
f
/2π=270MHz).
King’s Sarcoidosis Questionnaire (KSQ) – Validation study in Serbian speaking population of sarcoidosis patients
Authors: Stjepanovic Mihailo , Mihailovic-Vucinic Violeta , Gvozdenovic Branislav S. , Milin-Lazovic Jelena , Belic Slobodan , Djurdjevic Natasa , Maric Nikola , Golubovic Aleksa 
Published: September 2023

Introduction
Sarcoidosis is a multiorgan, multisystem chronic disease of unknown etiology and unpredictable course. Health status is reduced in sarcoidosis and assessing it is a difficult multitask effort due to many faces this disease might have. Recently, a new questionnaire for assessing health status in sarcoidosis was developed by a group of authors from England–King’s Sarcoidosis Questionnaire (KSQ). The benefit of KSQ is the ability to develop the best care plan for the patient, as well as to differentiate the efficacy of the administered treatment.

Objective
The aim of this study was to validate the KSQ in Serbian speaking population of sarcoidosis patients. The test itself is a modular, multi-organ health status measure for patients with sarcoidosis for use in clinic and the evaluation of therapies. The correlation of KSQ with different clinical course of sarcoidosis (acute vs chronic disease) and with the clinical outcome status (COS) in sarcoidosis was also investigated.

Methods
A total of 159 biopsy positive sarcoidosis patients participated in this study. The average age of the participants was 49.67, majority was female (67.3%) and majority had only pulmonary form of sarcoidosis (71.7%). KSQ ‐ new disease-specific health status instrument, was compared with 5 other already existing instruments already used and validated in sarcoidosis (Saint George Respiratory Questionnaire- SGRQ, Daily Activity List -DAL, Fatigue Assessment Scale- FAS, Medical Research Council dyspnea scale–MRC, Borg Dyspnea Scale and 15D as general questionnaire.

Results
KSQ has significant correlation with other quality of life questionnaires already used in sarcoidosis. Translated version of KSQ shows significant internal reliability, similar to the original KSQ. Serbian version of KSQ has significant correlation with different clinical course of sarcoidosis and with COS as well. The translated version of KSQ is reliable sarcoidosis specific instrument for assessing health status in these patients.
Persistent Apoptotic Enteropathy in an Individual With Marginal Cell Lymphoma
Authors: Yuquimpo Kyle , Nathani Piyush , Patel Harsh , Decino Andrea , Unegbu Fortune , Hamza Ameer 
Published: September 2023

ABSTRACT
Apoptotic enteropathy is a histological finding of increased crypt apoptosis that is commonly associated with diarrhea. Several etiologies for this disease state including immunodeficiency, autoimmune, infection, hereditary, checkpoint inhibitors, immunosuppressants, and immunomodulators have been previously described. We describe an extremely rare case of a patient with marginal cell lymphoma treated with bendamustine, rituximab, and obinutuzumab presenting with severe, relapsing, chronic diarrhea with persistent apoptotic enteropathy of unknown etiology, despite hematological remission and discontinuation of treatment for 1 year.
Gastric Myeloid Sarcoma
Authors: Shaikh Abdullah S. , Almanza Huante Emmanuel , Taherian Mehran , Quesada Andres E. , Jabbour Elias J. , Thirumurthi Selvi 
Published: September 2023

ABSTRACT
Most gastric cancers are adenocarcinomas, but other malignancies can arise in the stomach. Patients with leukemia may develop myeloid sarcoma (MS) in the gastrointestinal tract. Our patient was a 68-year-old woman who was initially diagnosed with acute myeloid leukemia and underwent a matched unrelated stem cell transplantation. She was in remission for 10 years before developing a rare case of gastric MS without acute myeloid leukemia. She had partial response to chemotherapy but ultimately died because of infection. Gastric MS has an incidence of less than 1%. Gastrointestinal involvement usually involves the small intestine and rarely the stomach.
Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency
Authors: Elkin Baila , Allende Daniela S. , Sengupta Shreya 
Published: September 2023

ABSTRACT
Liver transplant is a rare phenomenon for pyruvate kinase deficiency (PKD)-related liver disease and can be mediated by multiple mechanisms. In this report, we present a 55-year-old man with PKD who had acute-on-chronic liver failure with kidney failure and marked hyperbilirubinemia. His liver disease was from recurrent cholangitis, cholestasis from hemolysis, and iron deposition (likely from both repeated transfusions in youth and chronic hemolysis), all consequences of his PKD. He received a liver transplant and had a good outcome. Our case highlights the mechanisms of liver injury in PKD and successful transplantation for this rare complication.
Impact of War on the Natural Preserve Fund: Challenges for the Development of Ecological Tourism and Environmental Protection
Authors: KUCHER Anatolii , HONCHAROVA Anna , KUCHER Lesia , BIELOBORODOVA Mariia , BONDARENKO Liudmyla 
Published: September 2023

The global deterioration of the quality of the natural environment causes an increase in the importance of ecological tourism, primarily at the sites of the nature reserve fund. This paper is one of the first attempts to fill the existing gaps in the question of the impact of war on protected natural areas. The article determines the development trends, current state, and problems of the objects of the nature reserve fund in Ukraine in the conditions of unjustified full-scale russian military aggression and makes an approximate calculation of the damages caused as a result of hostilities. It was established that during 2012–2020, the number of objects of the nature reserve fund in Ukraine increased by 605 units or by 7.5 %; the area of these objects increased by 562,460.6 hectares or by 14.3 %. Due to russian military aggression, danger threatens 900 protected areas, which is 1.2 million hectares or about 30 % of the area of all protected areas of Ukraine. The damage calculation was carried out on the example of the Feldman EcoPark regional landscape park in the Dergachy district of the Kharkiv region. It was established that the approximate estimate of damages from the loss of ecosystem services of this landscape park as of 20.05.2022 was 16,979.5 thousand USD, including in terms of ecosystem services: (i) recreation and ecotourism – 13,846.2 thousand USD; (ii) air purification from solid fine particles and harmful gases – 272.1 thousand USD; (iii) biodiversity habitat – 2,861.3 thousand USD. In addition, the amount of damage caused to the regional landscape park due to the loss of animals, calculated based on special fees for calculating the amount of damage to the nature reserve fund, amounts to 63,350 USD. The determined damage estimates are preliminary and need to be clarified after the end of the war.
PYROLYZER PRODUCTION SYSTEM FOR WASTE MANAGEMENT USING GROUP TECHNOLOGY APPROACH
Authors: Rifai Achmad Pratama , Wibisono Ragil Aditya , Sari Dwi Kumala , Sari Wangi Pandan 
Published: September 2023

Waste management methods in Indonesia largely rely on unsustainable practices such as open dumping and landfills which urgently need transformation. Pyrolysis is one alternative solution for waste problems as it can process waste into other products. As the existing production system was not set up to manufacture this machine, we proposed a production system to produce a pyrolizer so that a more effective and efficient production process can be achieved. In this study, we employed Group Technology approach using Rank Order Clustering (ROC) method to create cell manufacturing groups. Based on our evaluation on the shortest material movement, we produced 2 different cells to manufacture the pyrolyzer. Cell, I contained plate cutting, drilling, pipe cutting, and bending machines (M2, M5, M3, M4), whilst Cell 2 contained rolling and lathe machines (M1, M6). It also contained main reactor, pyrolyzer reactor burner, middle condenser, upper access door, bottom access door, upper condenser, bottom condenser components (A, F, H, B, C, G, I). Out of the sixteen components to be made, seven components were in Cell I whereas the other nine were in Cell II (N, P, J, E, D, K , L, M, O) comprising burner case, access ladders, separators, firewalls, reactor base frames, condenser frames, gas piping, water piping, and sprinklers components. By applying this group technology method to the pyrolyzer production system, the production process could be carried out in a more efficient and organized manner.