bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacto de la inmunonutrición en la evolución de los pacientes con esclerosis múltiple mayores de 20 años de edad: revisión narrativa
Authors: Salcedo-Hurtado José Guillermo , Alvarez-Osorio Susana Mireya , Nossa-Martínez Diana Paola , Vergara-Jiménez Carmen Cecilia 
Published: September 2023

Introducción: la esclerosis múltiple (EM) es una enfermedad inflamatoria crónica ocasionada por múltiples factores que afectan al sistema nervioso central (SNC), lo que conlleva discapacidades, principalmente, en los adultos jóvenes. La nutrición está dentro de estos factores patogénicos y más recientemente se incluye la disfunción inmunitaria, local y sistémica que produce la EM en la microbiota intestinal (MBI), y afecta órganos como el cerebro.
Objetivo: en esta revisión narrativa se analizó el impacto de la terapéutica con nutrientes específicos (inmunonutrientes) en los síntomas y la progresión de la enfermedad en pacientes adultos jóvenes con EM.
Método: se realizó una búsqueda de artículos en las plataformas PubMed y MedLine entre enero de 2012 y diciembre de 2022.
Resultados: la EM destruye la mielina, lo que produce áreas de desmielinización en la sustancia blanca. Teniendo en cuenta este componente inflamatorio, la investigación muestra que nutrientes específicos como probióticos, ácidos grasos omega-3 (ω-3) y la vitamina D, por sus efectos favorables en la modulación de la inflamación, presentan impactos positivos en los síntomas de estos pacientes; no así para frenar su evolución.
Conclusiones: el uso de suplementación con inmunonutrientes reporta efectos favorables en paciente con EM. Ante la escasa evidencia sobre el tema, con esta revisión se pretende seguir aportando a la literatura en desarrollo sobre el uso de estos nutrientes en pacientes adultos jóvenes con EM.
Continuance Intention Pada Aplikasi Mobile Payment Dengan Menggunakan Extended Expectation Confirmation Model
Authors: Ubaidillah M. Yahya , Pramana Edwin , Chandra Francisca Haryanti 
Published: September 2023

This study aims to identify the factors that influence the intention to continue using the mobile payment application during the new normal period after the COVID-19 pandemic, using the Extended Expectation Confirmation Model (EECM) approach. EECM combines aspects of the Expectation Confirmation Model (ECM) with other external factors, ECM is used to understand and explain decision-making related to the continued use of mobile payments. This research was conducted by analyzing data from respondents who have used mobile payment applications after the pandemic. The data was collected through an online survey and analyzed using Structural Equation Modeling (SEM) with the help of Analysis of Moment Structures (AMOS) software, 406 individuals were selected to serve as research participants. The results of the analysis show that factors such as satisfaction, and trust have a significant influence on the continuance intention of mobile payments. In addition, in the context of the new normal, factor such as social influence factors are known to have no significant influence on mobile payment continuance intention. As a result, this research contributes to understanding the factors that influence the intention to continue using mobile payment applications. The validity and reliability test results show that the survey instrument used has an adequate level of validity and reliability, supporting the quality and reliability of the analysis conducted.
Síndrome de LAHS asociado a lupus eritematoso sistémico
Authors: Gómez-Pastrana Juan Carlos 
Published: September 2023

Introducción: los fenómenos tromboembólicos hacen parte de las manifestaciones hematológicas más comunes de los pacientes con lupus eritematoso sistémico (LES) que presentan anticoagulante lúpico, mientras que los eventos hemorrágicos son menos frecuentes y suelen manifestarse en presencia de deficiencia de factor II. El síndrome de LAHS es una afección rara y su asociación con LES es infrecuente, especialmente en etapa adulta.
Presentación del caso: se presenta el caso de un paciente masculino de 19 años diagnosticado con síndrome de LAHS asociado a LES con compromiso renal y cutáneo manifestado por púrpuras en extremidades inferiores y hematuria. Se instauró tratamiento con pulsos de corticoides, ciclofosfamida y micofenolato mofetil de forma temprana observándose una adecuada respuesta clínica.
Conclusión: conocer la asociación entre el síndrome de LAHS y LES permite sospechar esta entidad en pacientes con trastornos adquiridos de la coagulación y reconocerla como manifestación inicial de una enfermedad sistémica subyacente. El diagnóstico temprano y tratamiento oportuno reduce la mortalidad en estos pacientes.
Un caso inusual de sintomático respiratorio en infección por VIH
Authors: Espinoza-Almanza Carmelo José , Cruz-Marroquín Carlos , Delgado-Marrugo Raúl , Cortés-Luna Jorge Alberto 
Published: September 2023

Se valoró un hombre de 68 años en la consulta externa de infectología por un diagnóstico reciente de infección por VIH. Consultó 15 meses antes por pérdida no intencionada de peso (30 kg) asociada a astenia y adinamia. Aunado al cuadro, llevaba seis meses presentando tos con expectoración, sin disnea, sin otra sintomatología relacionada. Negó distermias, sudoración nocturna, disnea o síntomas gastrointestinales. No obstante, dos días previos a la consulta ambulatoria presentó fiebre no cuantificada, sudoración y diaforesis.
Tenía antecedente de diabetes mellitus tipo 2 diagnosticada tres meses antes con hemoglobina glicada de 10.1%; polineuropatía sensitiva desmielinizante en miembros inferiores de etiología no clara, estaba en estudio; lupus eritematoso sistémico (LES) desde hacía cuatro meses, diagnosticado al parecer por sospecha de nefritis lúpica sin estudio histopatológico y trombocitopenia inmune. Tomaba deflazacort de 30 mg (sin especificar el momento de inicio), enalapril 2.5 mg/día, atorvastatina 20 m/noche, y carvedilol 6.25 mg/cada 12 horas. También le habían indicado tomar hidroxicloroquina y micofenolato mofetilo para el tratamiento del lupus; además, metformina + sitagliptina e insulina (no recuerda dosis), el paciente no los había iniciado. No tenía antecedentes quirúrgicos, alérgicos, tóxicos ni exposicionales de importancia.
Al examen físico fue encontrado febril, taquicárdico, taquipneico y con saturación de oxígeno en límite inferior (88-90% a 2500 msnm), presentaba adenopatías axilares bilaterales menores a 2 cm, no dolorosas, sin otros hallazgos remarcables al examen físico. Su talla era de 1.73 m y su peso de 60 kg. Ingresó a hospitalización para ampliar estudios. Luego de ingresado el paciente aportó los paraclínicos ambulatorios registrados en la historia clínica, los cuales pueden observarse en la Tabla 1. Los paraclínicos tomados al ingreso de la hospitalización se encuentran en la Tabla 2.
Keberhasilan Persilangan Edamame dengan Tiga Varietas Kedelai (Glycine max) Serta Resiprokalnya
Authors: Arnanto Driska , Maryani Yekti , Kusumawati Dian Eka 
Published: September 2023

Kedelai merupakan komoditas pertanian penghasil biji yang memiliki kandungan protein nabati tinggi sehingga layak untuk dikonsumsi setiap hari. Pemuliaan tanaman merupakan salah satu metode untuk meningkatkan produktivitas nasional kedelai salh satunya dengan persilangan intraspesifik. Tujuan dari penelitian ini adalah untuk mengetahui tingkat keberhasilan persilangan Edamame dengan tiga varietas unggul serta resiprokalnya. Penelitian dilaksanakan pada bulan Oktober 2022 hingga Februari 2023 di Greenhouse Asrama Dewa Fakultas Pertanian Universitas Sarjanawiyata Tamansiswa. Keberhasilan persilangan ini menggunakan metode persilangan set dialel lengkap. Data yang diperoleh dianalisis menggunakan analisis ragam pada level nyata 5% untuk parameter umur berbunga, jumlah biji per polong, dan keberhasilan persilangan dan diuji dengan jarak berganda Duncan (Duncan’s Multiple Range Test) pada level 5%. Hasil penelitian menunjukkan persilangan edamame dengan tiga varietas kedelai Wilis, Anjasmoro, dan Grobogan, tingkat keberhasilan persilangan yang paling tinggi pada varietas Wilis×Edamame (29,9%), sedangkan yang paling rendah adalah Grobogan×Edamame (26,7%). Parameter jumlah biji per polong menunjukkan paling banyak pada persilangan Edamame dengan Wilis (7,3 biji). Sedangkan pada persilangan resiprokalnya keberhasilan persilangan tertinggi dan jumlah biji per polong ditunjukkan oleh persilangan Wilis dengan Edamame (52,3% dan 15 biji per polong). Berdasarkan hasil penelitian tersebut tingkat keberhasilan paling tinggi ditunjukkan oleh Edamame sebagai jantan dengan Wilis sebagai betina (52,3%).
Retrospective evaluation of children with non-steroidal anti-inflammatory drug allergy
Authors: AYDOĞDU Ayşe , AKÇAM Nurullah Yekta 
Published: September 2023

Aim: Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs and are among the drug-related hypersensitivity reactions after antibiotics. There are limited studies evaluating nonsteroidal drug reactions in children. In this study, we aimed to evaluate the concomitant atopic diseases, admission clinic, laboratory findings and drug provocation test results of children with a pre-diagnosis of nonsteroidal drug reaction and who underwent allergy tests, retrospectively .
Methods: In this study, patients who applied to the pediatric allergy outpatient clinic due to nonsteroidal drug reaction were included. In this group of patients, age, gender, fx5 (nutrient mix specific IgE), phadiatop (inhalant allergen mix specific IgE), skin prick tests and drug provocation tests were recorded from their files. Demographic and clinical features of the cases were compared.
Results: 61 patients with suspected NSAIDs allergy were included in the study. When the admission clinics of the patients were evaluated, 54% (n:33) had urticaria, 22.9% (n:14) had isolated angioedema, 6.5% (n:4) had urticaria angioedema, 14.7% (n:9) had maculopapular eruption . Only 1 patient presented with anaphylaxis. NSAIDs allergy was confirmed in 16.3% (n:10) of the patients.. Single ibuprofen sensitivity was detected in 13.1% of patients (n:8), both paracetamol and ibuprofen sensitivity were detected in 1 patient (1.6%), and single paracetamol sensitivity was detected in 1 patient (1.6%).
Conclusions: It is usually not easy to detect drug allergies in patients. These patients may usually misdiagnosed as NSAIDs allergy. In our study, it was revealed that drug provocation tests should be performed to confirm the diagnosis in case of suspected NSAIDs allergy.
Experiences in endoscopic ultrasonography at a tertiary center general surgery endoscopy unit
Authors: YÜKSEL Sercan , TOPAL Uğur , UZUNKULAOĞLU Mert , ŞİMŞEK Şener , AKIN Emrah , KARAKÖSE Erdal , BEKTAŞ Hasan 
Published: September 2023

Aim: Endoscopic ultrasonography (EUS) is used for diagnosing pathologies in the gastrointestinal system and surrounding organs. This study aims to share the experiences and results of EUS and biopsy at a tertiary center general surgery endoscopy unit, in the context of the literature.
Methods: Patients who underwent EUS imaging at the general surgery endoscopy unit between January 2021 and January 2022 were retrospectively reviewed. Demographic characteristics, EUS biopsy indications, clinical pre-diagnoses, preoperative imaging methods, biopsy counts, and results, as well as complications, were analyzed.
Results: The mean age of the 292 patients was 56.5 years, with 53.8% being male. The most common EUS indication was a mass in the pancreas, accounting for 62%. Endoscopic fine-needle aspiration biopsy was performed on 127 (43.4%) patients, and the mean diameter of biopsied masses was 35.1 mm. Malignancy was detected in 58.2% of the biopsied patients. Based on biopsy and lesion characteristics, 49.3% of patients were followed up, 27.4% underwent surgery, 15.4% received oncological treatment, and 7.9% were given endoscopic retrograde cholangiopancreatography.
Conclusion: The role of EUS in the diagnosis and treatment of gastrointestinal malignancies, pancreatic diseases, and biliary diseases continues to evolve. We believe that EUS plays a key role in the multidisciplinary management of complex surgical and oncology patients and those with pancreatobiliary disorders.
Hypomagnesemia and Calcineurin Inhibitors in Kidney Transplant Recipients
Authors: ONAN Engin , PAYDAS Saime , BALAL Mustafa , GEYGEL Nebi Cankat , AKKAYA İbrahim , TATAR Erhan 
Published: September 2023

Aim: Post-transplant hypomagnesemia is a frequently encountered and significant electrolyte disorder and is more common in patients using calcineurin inhibitors (CNIs). This study aimed to evaluate the frequency of hypomagnesemia and accompanying conditions in the outpatient follow-up of renal transplant recipients.
Methods: This cross-sectional study included 236 renal transplant patients. Demographic characteristics of the patients and their biochemical values, including drug levels, were recorded.
Results: Of the patients, 69 (29.2%) were female, and 194 (82.3%) were living donor recipients. The mean age of the entire group was 43.1 years. The frequency of hypomagnesemia was 40% (10/25) in the first 12 months, 26.1% (23/88) between the 12th and 60th months, 26% (32/123) after 60 months, and 27.5% (65/236) in all patients. In patients with higher levels of tacrolimus compared to those with the target level, the frequency of hypomagnesemia increased in those with a posttransplant period of 12-60 months (40.9% vs. 20.8%, p: 0.018) and over 60 months (44% vs. 26%, p: 0.046). In addition, the magnesium (Mg+2) level was lower in patients using tacrolimus compared to those using cyclosporine (CsA) (1.80±0.18 vs 1.91±0.25, p: 0.003). The effect of hypomagnesemia on graft functions was statistically insignificant in all groups.
Conclusion: Hypomagnesemia is a common electrolyte disorder in the early and late periods after transplantation. In our study, hypomagnesemia did not differ according to proton pump inhibitor (PPI) use, gender, fasting blood glucose, and glomerular filtration rate. However, the frequency increased in patients using tacrolimus and those with above-target serum tacrolimus levels.
The Impact of the COVID-19 Pandemic on Anesthesia Management and Clinical Outcomes in Cesarean Section Surgery
Authors: BABAOĞLAN İlsev , LAFLI TUNAY Demet , ILGINEL Murat Türkeün , TOTİK DOĞAN Nazlı 
Published: September 2023

Giriş: Cerrahi hastalarda bilinen COVID-19 enfeksiyonu olmasa dahi pandemi sürecinde postoperatif morbidite ve mortalitenin artığı bilinmektedir. Bu çalışma ile, 2019 Eylül - 2020 Eylül tarihleri arasında sezaryen (C/S) ameliyatına alınan gebeler, pandemi öncesi ve sonrası olmak üzere iki ayrı grupta ele alınarak pandemi döneminin anestezi tercihi ile anne ve bebekle ilgili sonuçlar üzerine etkileri değerlendirilmek istenmiştir.
Gereç ve Yöntemler: Bu çalışmada üçüncü basamak bir hastanede bir yıllık deneyim kapsamında sezaryen ameliyatına alınan gebeler, COVID-19 pandemisi öncesi ve sonrası olmak üzere iki ayrı dönemde retrospektif olarak incelendi. Çalışmanın birincil sonuç ölçütü, pandemi döneminde C/S operasyonlarındaki rejyonel anestezi uygulanma oranları idi.
Bulgular: 1241 C/S olgusunun analiz edildiği bu çalışmanın sonuçlarına göre, anne yaşı, gebelik haftası, gravida, gebelikle ilgili morbiditeler, APGAR skoru dahil yenidoğana ait veriler ve C/S cerrahisi endikasyonları erken COVID-19 pandemisi döneminde değişikliğe uğramamıştır. Ancak anneye ait anemi dahil ek hastalık oranı, yenidoğan yoğun bakıma yatış oranı ve hastanede kalış süresi pandemic döneminde öncesine göre azalmış; rejyonel anestezi uygulamaları ve postoperatif maternal komplikasyon oranları ise artmıştır.
Sonuç: Bu çalışmada, obstetrik anesteziye dair gerek klinik uygulamalarda gerekse hasta sonuçlarında COVID-19 pandemisi dönemi ile birlikte çeşitli değişikliklerin ortaya çıktığı gözlenmiştir.
Anahtar Kelimeler: Sezaryen, COVID-19, obstetrik anestezi, pandemi.
Investigation of the Efficacy Results of Atmospheric Cold Plasma Against Multi-Resistant Bacterial Strains
Authors: TOGAY Alper , TEKİN Duygu , IRMAK Şeyma Ecem , ERCAN Utku , YILMAZ Nisel 
Published: September 2023

Giriş: Amacımız Atmosferik Soğuk Plazma ile muamele edilmiş PBS'nin Gram pozitif ve Gram negatif çoklu ilaca dirençli bakterilere karşı etkinliğini araştırmaktır.
Gereç ve Yöntemler: Toplam 50 karbapenem dirençli Klebsiella pneumoniae ve 10 vankomisin dirençli Enterococcus faecium suşu çalışmaya dahil edilmiştir. 100 µl bakteri süspansiyonu (107 CFU/ml) üzerine 100 µl (1/2), 300 µl (3/4), 700 µl (7/8), 1500 µl (15/16), 3100 µl (31/32), 6300 µl ACP ile muamele edilmiş PBS eklenmiştir. Süspansiyon pipetlendikten sonra oda sıcaklığında 30 dakika inkübe edilmiş, koyun kanlı agara ekilmiş ve 37°C'de bir gece (16-18 saat) inkübe edilmiştir.
Bulgular: Çalışılan tüm suşlar ASP ile muamele edilmiş PBS çözeltisi tarafından inhibe edilmiştir. Verilen dilüsyonlar bakteri çoğalmasının tamamen inhibe olduğu dilüsyonlardır. K. pneumoniae suşlarının 45'i ACP ile muamele edilmiş PBS çözeltisi ile 3/4 konsantrasyonda tamamen inhibe olurken, K. pneumoniae suşlarının 5'i ACP ile muamele edilmiş PBS çözeltisi ile 7/8 konsantrasyonda tamamen inhibe olmuştur. Vankomisine dirençli E. faecium suşları, K. pneumonia suşlarına göre daha yüksek miktarlarda plazma ile inhibe edilmiştir. E. faecium suşlarından üçü (15/16), E. faecium suşlarından üçü (31/32), E. faecium suşlarından dördü (63/64) ACP ile muamele edilmiş PBS solüsyonu tarafından tamamen inhibe edilmiştir.
Sonuç: ACP ile muamele edilmiş PBS çözeltisinin önemli antibiyotiklere dirençli hem Gram-pozitif hem de Gram-negatif bakterilere karşı etkili olduğu bulunmuştur. Seçilen Gram-negatif ve Gram-pozitif bakterilerde inaktivasyon için gereken ASP ile muamele edilmiş PBS konsantrasyonunda farklılıklar gözlenmiştir. Bununla birlikte, hem Gram-negatif hem de Gram-pozitif enfeksiyonlarda mevcut tedavi seçenekleri gün geçtikçe azaldığı için bu yöntem umut vericidir. ASP ile muamele edilmiş PBS sıvılarının bir tedavi yöntemi olarak kullanılması için ileri çalışmalara ihtiyaç vardır.
Penyebab Terjadinya Perkawinan Di Bawah Umur Pada Masyarakat Suku Bajo (Studi di Desa Terapung Kecamatan Poleang Tenggara Kabupaten Bombana)
Authors: Salli Novinati  , Muh. Yusuf  , Muhammad Idrus  
Published: September 2023

Tujuan penelitian ini adalah untuk mengetahui penyebab terjadinya perkawinan di bawah umur pada Masyarakat Suku Bajo Di Desa Terapung Kecamatan Poleang Tenggara Kabupaten Bombana dan untuk mengetahui prosedur penyelesaian perkawinan di bawah umur pada Masyarakat Suku Bajo Di Desa Terapung Kecamatan Poleang Tenggara Kabupaten Bombana. Jenis penelitian ini adalah penelitian deskriptif menggunakan pendekatan kualitatif, 4 subjek informan, 8 responden. teknik pengumpulan data yang digunakan observasi, wawancara mendalam dan dokumentasi. Hasil penelitian ini menunjukkan bahwa yang menjadi penyebab perkawinan di bawah umur pada masyarakat Suku Bajo Desa Terapung Kecamatan Poleang Tenggara Kabupaten Bombana yaitu: (1) faktor ekonomi keluarga karena kurangya pendapatan orang tua sehingga orang tua atau anak memilih untuk dinikahkan atau menikah supaya dapat mengurangi beban keluarga, (2) faktor perjodohan karena adanya keinginan orang tua untuk mempererat hubungan keluarga dan untuk kebahagian anaknya, (3) faktor pendidikan, tingkat pendidikan yang rendah sehingga mendorong untuk cepat menikah, dan (4) pergaulan mempengaruhi perkawinan di bawah umur pada Masyarakat Suku Bajo Di Desa Terapung yaitu karena adanya hubungan antara kedua pasangan (pacaran). adapun prosedur penyelesaianya melalui dispensasi kawin dan isbad nikah.
Peranan Guru Pada Implementasi Kuriklum Merdeka Pada Komponen Pembuatan Modul Ajar Pendidikan Pancasila Di SMP Negeri 10 Kendari
Authors: Titin Adicita  , Hamuni  , Wa Ode Hijrah  
Published: September 2023

Tujuan penelitian ini adalah untuk menjelaskan peranan guru pada implementasi kurikulum merdeka pada komponen pembuatan modul ajar pembelajaran pendidikan Pancasila di SMP Negeri 10 Kendari dan hambatan peranan guru dalam mengimplementasikan kurikulum merdeka pada komponen pembuatan modul ajar pembelajaran pendidikan Pancasila di SMP Negeri 10 Kendari. Jenis penelitian ini adalah penelitian deskriptif menggunakan pendekatan kualitatif, responden dalam penelitian ini terdiri dari guru Pendidikan Pancasila sedangkan informan dalam penelitian ini terdiri dari kepala sekolah dan wakasek kurikulum. Teknik pengumpulan data yang digunakan yaitu observasi, wawancara mendalam dan dokumentasi. Hasil penelitian ini menunjukan bahwa peranan guru pada implementasi kurikulum merdeka pada komponen pembuatan modul ajar pembelajaran pendidikan Pancasila yaitu: (1) menentukan capaian pembelajaran, (2) menentukan tujuan pembelajaran, (3) menentukan alur tujuan pembelajaran, (4) melaksanakan asesmen, (5) merevisi modul (6) melaksanakan pembelajaran berdiferensiasi.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PERTUMBUHAN LABA PADA PERUSAHAAN PERTAMBANGAN YANG TERDAFTAR DI BEI DENGAN KEBIJAKAN DIVIDEN SEBAGAI VARIABEL INTERVENING
Authors: Sholehah Dhaimatus , Wiryaningtyas Dwi Perwitasari , Pramitasari Triska Dewi 
Published: September 2023

This study aims to analyze factors that influence profitability in mining companies listed on Indonesian Stock Exchange (IDX) with dividend policy as an intervening variable. The population of this study is all coal mining companies listed on Indonesian Stock Exchange (IDX) involving 28 companies. The sampling technique uses purposive sampling by choosing 10 samples. Data analysis and hypothesis testing use Partial Least Square - Structural Equation Modeling (PLS-SEM).
Hypothesis testing of direct and indirect effect use Smart PLS 3.0 application. The results of direct effect hypothesis testing indicate that liquidity has a positive but not significant effect on dividend policy, liquidity and solvency have a negative but not significant effect on profitability, and dividend policy has a significant negative effect on profitability. The results of indirect effect testing show that liquidity has a positive but not significant effect on profitability through dividend policy, solvency has a negative but not significant effect on profitability through dividend policy.
Latin American Scientific Production on Transsexuality in Scopus, 2010-2022
Authors: Chaparro Josué Turpo , Hernández Ronald M. , Saavedra-López Miguel A. , Carranza Renzo Felipe Esteban , Mamani-Benito Oscar , Ponce-Meza Jacqueline C. , Calle-Ramirez Xiomara M. 
Published: September 2023

The term transsexuality continues to be hotly debated in the literature and for many has become a scientific void. We sought to analyze the scientific production on transsexuality in Scopus, 2010-2022. Under a retrospective descriptive design, 624 articles were studied. It was found that 85.58% were research articles. Brazil has more research on the subject (41.83%); institutions in Brazil, Peru and Argentina have the highest production, and AIDS and Behavior and Plos One are the journals with the largest publications. The authors belong to Brazilian and Peruvian institutions. Research on transsexuality is minimal, so further research is needed.

Received: 10 April 2023 / Accepted: 22 August 2023 / Published: 5 September 2023