bluuebunny/crossref_metadata_2025_split huggingface dataset:
Petrological Traverse of the Olivine Cumulate Séítah Formation at Jezero Crater, Mars: A Perspective From SuperCam Onboard Perseverance
Authors: Beyssac O. , Forni O. , Cousin A. , Udry A. , Kah L. C. , Mandon L. , Clavé O. E. , Liu Y. , Poulet F. , Quantin Nataf C. , Gasnault O. , Johnson J. R. , Benzerara K. , Beck P. , Dehouck E. , Mangold N. , Alvarez Llamas C. , Anderson R. B. , Arana G. , Barnes R. , Bernard S. , Bosak T. , Brown A. J. , Castro K. , Chide B. , Clegg S. M. , Cloutis E. , Fouchet T. , Gabriel T. , Gupta S. , Lacombe G. , Lasue J. , Le Mouelic S. , Lopez‐Reyes G. , Madariaga J. M. , McCubbin F. M. , McLennan S. M. , Manrique J. A. , Meslin P. Y. , Montmessin F. , Núñez J. , Ollila A. M. , Ostwald A. , Pilleri P. , Pinet P. , Royer C. , Sharma S. K. , Schröder S. , Simon J. I. , Toplis M. J. , Veneranda M. , Willis P. A. , Maurice S. , Wiens R. C. ,   The SuperCam Team
Published: May 2023

AbstractSéítah is the stratigraphically lowest formation visited by Perseverance in the Jezero crater floor. We present the data obtained by SuperCam: texture by imagery, chemistry by Laser‐Induced Breakdown Spectroscopy, and mineralogy by Supercam Visible and Infrared reflectance and Raman spectroscopy. The Séítah formation consists of igneous, weakly altered rocks dominated by millimeter‐sized grains of olivine with the presence of low‐Ca and high‐Ca pyroxenes, and other primary minerals (e.g., plagioclase, Cr‐Fe‐Ti oxides, phosphates). Along a ∼140 m long section in Séítah, SuperCam analyses showed evidence of geochemical and mineralogical variations, from the contact with the overlying Máaz formation, going deeper in the formation. Bulk rock and olivine Mg#, grain size, olivine content increase gradually further from the contact. Along the section, olivine Mg# is not in equilibrium with the bulk rock Mg#, indicating local olivine accumulation. These observations are consistent with Séítah being the deep ultramafic member of a cumulate series derived from the fractional crystallization and slow cooling of the parent magma at depth. Possible magmatic processes and exhumation mechanisms of Séítah are discussed. Séítah rocks show some affinity with some rocks at Gusev crater, and with some Martian meteorites suggesting that such rocks are not rare on the surface of Mars. Séítah is part of the Nili Fossae regional olivine‐carbonate unit observed from orbit. Future exploration of Perseverance on the rim and outside of the crater will help determine if the observations from the crater floor can be extrapolated to the whole unit or if this unit is composed of distinct sub‐units with various origins.
SIR‐HUXt—A Particle Filter Data Assimilation Scheme for CME Time‐Elongation Profiles
Authors: Barnard Luke , Owens Mathew , Scott Chris , Lang Matthew , Lockwood Mike 
Published: May 2023

AbstractWe present SIR‐HUXt, the integration of a sequential importance resampling data assimilation scheme with the HUXt solar wind model. SIR‐HUXt assimilates the time‐elongation profiles of Coronal Mass Ejection (CME) fronts in the low heliosphere, like those extracted from heliospheric imager (HI) data. Observing System Simulation Experiments are used to explore SIR‐HUXt's performance for a simple synthetic CME scenario of an Earth directed CME in a uniform solar wind, where the CME is initialized with the average CME speed and width. These experiments are performed for a range of observer locations, from 20° to 90° behind Earth, spanning the L5 point where ESA's Vigil mission will return HI data for operational space weather forecasting. For this idealized scenario, SIR‐HUXt performs well at constraining the CME speed, and has some success at constraining the CME longitude while the CME width is largely unconstrained by SIR‐HUXt. Rank‐histograms suggest the SIR‐HUXt ensembles are well calibrated, with no indications of bias or under/over dispersion. Improved constraints on the initial CME speed lead to improvements in the CME transit time and arrival speed. For an L5 observer, SIR‐HUXt reduced the transit time and arrival speed uncertainties by 69% and 63%. Therefore, SIR‐HUXt could improve the real‐world representivity of HUXt simulations and reduce the uncertainty of CME arrival time forecasts. The idealized scenario studied here likely enhances SIR‐HUXt's performance relative to the challenge of simulating real‐world CMEs and solar wind conditions. Future work should validate SIR‐HUXt with case studies of real CMEs in structured solar wind.
What Is the Radiation Impact of Extreme Solar Energetic Particle Events on Mars?
Authors: Zhang Jian , Guo Jingnan , Dobynde Mikhail I. 
Published: May 2023

AbstractSolar Energetic Particles (SEP) are one of the major sources of the Martian radiation environment. It is important to understand the SEP‐induced Martian radiation environment for future human habitats on Mars. Due to the lack of a global intrinsic magnetic field, Solar Energetic Particles (SEPs) can directly propagate through and interact with its atmosphere before reaching the surface and subsurface of Mars. Mars has many high mountains and low‐altitude craters where the atmospheric thickness can be more than 10 times different than one another. The SEP‐induced surface radiation level may therefore be very different from one location to another. We thus consider the influence of the atmospheric depths on the Martian radiation levels including the absorbed dose, dose equivalent, and (human‐)body effective dose induced by SEPs at varying heights above and below the Martian surface. The state‐of‐the‐art Atmospheric Radiation Interaction Simulator based on GEometry And Tracking Monte‐Carlo method has been employed for simulating particle interactions with the Martian atmosphere and terrain. We find that even the thinnest Martian atmosphere reduces radiation dose from that in deep space by at least 65%, and the shielding effect increases for denser atmosphere. Furthermore, we present a method to quickly forecast the SEP‐induced radiation in different regions of Mars with different surface pressures.
Yersinia pestis genomes reveal plague in Britain 4000 years ago
Authors: Swali Pooja , Schulting Rick , Gilardet Alexandre , Kelly Monica , Anastasiadou Kyriaki , Glocke Isabelle , McCabe Jesse , Williams Mia , Audsley Tony , Loe Louise , Fernández-Crespo Teresa , Ordoño Javier , Walker David , Clare Tom , Cook Geoff , Hodkinson Ian , Simpson Mark , Read Stephen , Davy Tom , Silva Marina , Hajdinjak Mateja , Bergström Anders , Booth Thomas , Skoglund Pontus 
Published: May 2023

AbstractExtinct lineages of Yersinia pestis, the causative agent of the plague, have been identified in several individuals from Eurasia between 5000 and 2500 years before present (BP). One of these, termed the ‘LNBA lineage’ (Late Neolithic and Bronze Age), has been suggested to have spread into Europe with human groups expanding from the Eurasian steppe. Here, we show that the LNBA plague was spread to Europe’s northwestern periphery by sequencing three Yersinia pestis genomes from Britain, all dating to ~4000 cal BP. Two individuals were from an unusual mass burial context in Charterhouse Warren, Somerset, and one individual was from a single burial under a ring cairn monument in Levens, Cumbria. To our knowledge, this represents the earliest evidence of LNBA plague in Britain documented to date. All three British Yersinia pestis genomes belong to a sublineage previously observed in Bronze Age individuals from Central Europe that had lost the putative virulence factor yapC. This sublineage is later found in Eastern Asia ~3200 cal BP. While the severity of the disease is currently unclear, the wide geographic distribution within a few centuries suggests substantial transmissibility.
Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family
Authors: Deshmukh Fanindra Kumar , Ben-Nissan Gili , Olshina Maya A. , Füzesi-Levi Maria G. , Polkinghorn Caley , Arkind Galina , Leushkin Yegor , Fainer Irit , Fleishman Sarel J. , Tawfik Dan , Sharon Michal 
Published: May 2023

AbstractControlled degradation of proteins is necessary for ensuring their abundance and sustaining a healthy and accurately functioning proteome. One of the degradation routes involves the uncapped 20S proteasome, which cleaves proteins with a partially unfolded region, including those that are damaged or contain intrinsically disordered regions. This degradation route is tightly controlled by a recently discovered family of proteins named Catalytic Core Regulators (CCRs). Here, we show that CCRs function through an allosteric mechanism, coupling the physical binding of the PSMB4 β-subunit with attenuation of the complex’s three proteolytic activities. In addition, by dissecting the structural properties that are required for CCR-like function, we could recapitulate this activity using a designed protein that is half the size of natural CCRs. These data uncover an allosteric path that does not involve the proteasome’s enzymatic subunits but rather propagates through the non-catalytic subunit PSMB4. This way of 20S proteasome-specific attenuation opens avenues for decoupling the 20S and 26S proteasome degradation pathways as well as for developing selective 20S proteasome inhibitors.
Traces of electron-phonon coupling in one-dimensional cuprates
Authors: Tang Ta , Moritz Brian , Peng Cheng , Shen Zhi-Xun , Devereaux Thomas P. 
Published: May 2023

AbstractThe appearance of certain spectral features in one-dimensional (1D) cuprate materials has been attributed to a strong, extended attractive coupling between electrons. Here, using time-dependent density matrix renormalization group methods on a Hubbard-extended Holstein model, we show that extended electron-phonon (e–ph) coupling presents an obvious choice to produce such an attractive interaction that reproduces the observed spectral features and doping dependence seen in angle-resolved photoemission experiments: diminished 3kF spectral weight, prominent spectral intensity of a holon-folding branch, and the correct holon band width. While extended e–ph coupling does not qualitatively alter the ground state of the 1D system compared to the Hubbard model, it quantitatively enhances the long-range superconducting correlations and suppresses spin correlations. Such an extended e–ph interaction may be an important missing ingredient in describing the physics of the structurally similar two-dimensional high-temperature superconducting layered cuprates, which may tip the balance between intertwined orders in favor of uniform d-wave superconductivity.
Chemical design of electronic and magnetic energy scales of tetravalent praseodymium materials
Authors: Ramanathan Arun , Kaplan Jensen , Sergentu Dumitru-Claudiu , Branson Jacob A. , Ozerov Mykhaylo , Kolesnikov Alexander I. , Minasian Stefan G. , Autschbach Jochen , Freeland John W. , Jiang Zhigang , Mourigal Martin , La Pierre Henry S. 
Published: May 2023

AbstractLanthanides in the trivalent oxidation state are typically described using an ionic picture that leads to localized magnetic moments. The hierarchical energy scales associated with trivalent lanthanides produce desirable properties for e.g., molecular magnetism, quantum materials, and quantum transduction. Here, we show that this traditional ionic paradigm breaks down for praseodymium in the tetravalent oxidation state. Synthetic, spectroscopic, and theoretical tools deployed on several solid-state Pr4+-oxides uncover the unusual participation of 4f orbitals in bonding and the anomalous hybridization of the 4f1 configuration with ligand valence electrons, analogous to transition metals. The competition between crystal-field and spin-orbit-coupling interactions fundamentally transforms the spin-orbital magnetism of Pr4+, which departs from the Jeff = 1/2 limit and resembles that of high-valent actinides. Our results show that Pr4+ ions are in a class on their own, where the hierarchy of single-ion energy scales can be tailored to explore new correlated phenomena in quantum materials.
Molecular patterns identify distinct subclasses of myeloid neoplasia
Authors: Kewan Tariq , Durmaz Arda , Bahaj Waled , Gurnari Carmelo , Terkawi Laila , Awada Hussein , Ogbue Olisaemeka D. , Ahmed Ramsha , Pagliuca Simona , Awada Hassan , Kubota Yasuo , Mori Minako , Ponvilawan Ben , Al-Share Bayan , Patel Bhumika J. , Carraway Hetty E. , Scott Jacob , Balasubramanian Suresh K. , Bat Taha , Madanat Yazan , Sekeres Mikkael A. , Haferlach Torsten , Visconte Valeria , Maciejewski Jaroslaw P. 
Published: May 2023

AbstractGenomic mutations drive the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia. While morphological and clinical features have dominated the classical criteria for diagnosis and classification, incorporation of molecular data can illuminate functional pathobiology. Here we show that unsupervised machine learning can identify functional objective molecular clusters, irrespective of anamnestic clinico-morphological features, despite the complexity of the molecular alterations in myeloid neoplasia. Our approach reflects disease evolution, informed classification, prognostication, and molecular interactions. We apply machine learning methods on 3588 patients with myelodysplastic syndromes and secondary acute myeloid leukemia to identify 14 molecularly distinct clusters. Remarkably, our model shows clinical implications in terms of overall survival and response to treatment even after adjusting to the molecular international prognostic scoring system (IPSS-M). In addition, the model is validated on an external cohort of 412 patients. Our subclassification model is available via a web-based open-access resource (https://drmz.shinyapps.io/mds_latent).
Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown
Authors: Aydin Sidar , Pareja Javier , Schallenberg Vivianne M. , Klopstein Armelle , Gruber Thomas , Page Nicolas , Bouillet Elisa , Blanchard Nicolas , Liblau Roland , Körbelin Jakob , Schwaninger Markus , Johnson Aaron J. , Schenk Mirjam , Deutsch Urban , Merkler Doron , Engelhardt Britta 
Published: May 2023

AbstractBlood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8+ T cells are found in MS lesions, and antigen (Ag) presentation at the BBB has been proposed to promote CD8+ T cell entry into the CNS. Here, we show that brain endothelial cells process and cross-present Ag, leading to effector CD8+ T cell differentiation. Under physiological flow in vitro, endothelial Ag presentation prevented CD8+ T cell crawling and diapedesis resulting in brain endothelial cell apoptosis and BBB breakdown. Brain endothelial Ag presentation in vivo was limited due to Ag uptake by CNS-resident macrophages but still reduced motility of Ag-specific CD8+ T cells within CNS microvessels. MHC class I-restricted Ag presentation at the BBB during neuroinflammation thus prohibits CD8+ T cell entry into the CNS and triggers CD8+ T cell-mediated focal BBB breakdown.
Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase
Authors: Zhan Meixiao , Ding Yufeng , Huang Shanzhou , Liu Yuhang , Xiao Jing , Yu Hua , Lu Ligong , Wang Xiongjun 
Published: May 2023

AbstractTo overcome chemotherapy resistance, novel strategies sensitizing cancer cells to chemotherapy are required. Here, we screen the lysyl-oxidase (LOX) family to clarify its contribution to chemotherapy resistance in liver cancer. LOXL3 depletion significantly sensitizes liver cancer cells to Oxaliplatin by inducing ferroptosis. Chemotherapy-activated EGFR signaling drives LOXL3 to interact with TOM20, causing it to be hijacked into mitochondria, where LOXL3 lysyl-oxidase activity is reinforced by phosphorylation at S704. Metabolic adenylate kinase 2 (AK2) directly phosphorylates LOXL3-S704. Phosphorylated LOXL3-S704 targets dihydroorotate dehydrogenase (DHODH) and stabilizes it by preventing its ubiquitin-mediated proteasomal degradation. K344-deubiquitinated DHODH accumulates in mitochondria, in turn inhibiting chemotherapy-induced mitochondrial ferroptosis. CRISPR-Cas9-mediated site-mutation of mouse LOXL3-S704 to D704 causes a reduction in lipid peroxidation. Using an advanced liver cancer mouse model, we further reveal that low-dose Oxaliplatin in combination with the DHODH-inhibitor Leflunomide effectively inhibit liver cancer progression by inducing ferroptosis, with increased chemotherapy sensitivity and decreased chemotherapy toxicity.
Facile conversion of water to functional molecules and cross-linked polymeric films with efficient clusteroluminescence
Authors: Song Bo , Zhang Jianyu , Zhou Jiadong , Qin Anjun , Lam Jacky W. Y. , Tang Ben Zhong 
Published: May 2023

AbstractExploring approaches to utilize abundant water to synthesize functional molecules and polymers with efficient clusteroluminescence properties is highly significant but has yet to be reported. Herein, a chemistry of water and alkyne is developed. The synthesized products are proven as nonaromatic clusteroluminogens that could emit visible light. Their emission colors and luminescent efficiency could be adjusted by manipulating through-space interaction using different starting materials. Besides, the free-standing polymeric films with much high photoluminescence quantum yields (up to 45.7%) are in situ generated via a water-involved interfacial polymerization. The interfacial polymerization-enhanced emission of the polymeric films is observed, where the emission red-shifts and efficiency increases when the polymerization time is prolonged. The synthesized polymeric film is also verified as a Janus film. It exhibits a vapor-triggered reversible mechanical response which could be applied as a smart actuator. Thus, this work develops a method to synthesize clusteroluminogens using water, builds a clear structure-property relationship of clusteroluminogens, and provides a strategy to in situ construct functional water-based polymeric films.
Data-driven direct diagnosis of Li-ion batteries connected to photovoltaics
Authors: Dubarry Matthieu , Costa Nahuel , Matthews Dax 
Published: May 2023

AbstractPhotovoltaics supply a growing share of power to the electric grid worldwide. To mitigate resource intermittency issues, these systems are increasingly being paired with electrochemical energy storage devices, e.g., Li-ion batteries, for which ensuring long and safe operation is critical. However, in this operation framework, secondary Li-ion batteries undergo sporadic usage, which prevents the application of standard diagnostic methods. Here, we propose a diagnostic methodology that uses machine learning algorithms trained directly on data obtained from photovoltaic charging of Li-ion batteries. The training is carried out on synthetic voltage data at various degradation conditions calculated from clear sky model irradiance data. The method is validated using synthetic voltage responses calculated from plane of array irradiance observations for a photovoltaic system located in Maui, HI, USA. We report an average root mean square error of 2.75% obtained for more than 10,000 different degradation paths with 25% or less degradation on the Li-ion cells.
Unraveling chirality transfer mechanism by structural isomer-derived hydrogen bonding interaction in 2D chiral perovskite
Authors: Son Jaehyun , Ma Sunihl , Jung Young-Kwang , Tan Jeiwan , Jang Gyumin , Lee Hyungsoo , Lee Chan Uk , Lee Junwoo , Moon Subin , Jeong Wooyong , Walsh Aron , Moon Jooho 
Published: May 2023

AbstractIn principle, the induced chirality of hybrid perovskites results from symmetry-breaking within inorganic frameworks. However, the detailed mechanism behind the chirality transfer remains unknown due to the lack of systematic studies. Here, using the structural isomer with different functional group location, we deduce the effect of hydrogen-bonding interaction between two building blocks on the degree of chirality transfer in inorganic frameworks. The effect of asymmetric hydrogen-bonding interaction on chirality transfer was clearly demonstrated by thorough experimental analysis. Systematic studies of crystallography parameters confirm that the different asymmetric hydrogen-bonding interactions derived from different functional group location play a key role in chirality transfer phenomena and the resulting spin-related properties of chiral perovskites. The methodology to control the asymmetry of hydrogen-bonding interaction through the small structural difference of structure isomer cation can provide rational design paradigm for unprecedented spin-related properties of chiral perovskite.
The global power sector’s low-carbon transition may enhance sustainable development goal achievement
Authors: Peng Kun , Feng Kuishuang , Chen Bin , Shan Yuli , Zhang Ning , Wang Peng , Fang Kai , Bai Yanchao , Zou Xiaowei , Wei Wendong , Geng Xinyi , Zhang Yiyi , Li Jiashuo 
Published: May 2023

AbstractThe low-carbon power transition, which is key to combatting climate change, has far-reaching effects on achieving the Sustainable Development Goals (SDGs) in terms of issues such as resource use, environmental emissions, employment, and many more. Here, we assess the potential impacts of the power transition on progress toward achieving multiple SDGs (covering 18 targets across the 17 goals) across 49 economies under nine socioeconomic and climate scenarios. We find that the low-carbon power transition under the representative concentration pathway (RCP)2.6 scenarios could lead to an approximately 11% improvement in the global SDG index score from 54.70 in 2015 to 59.89-61.33 in 2100. However, the improvement would be significantly decreased to 4.42%-7.40% and 7.55%-8.93% under the RCP6.0 and RCP4.5 scenarios, respectively. The power transition could improve the overall SDG index in most developed economies under all scenarios while undermining their resource-related SDG scores. Power transition-induced changes in international trade would improve the SDG progress of developed economies but jeopardize that of developing economies, which usually serve as resource hubs for meeting the demand for low-carbon power transition in developed economies.
A 5-emotions stimuli set for emotion perception research with full-body dance movements
Authors: Christensen Julia F. , Bruhn Laura , Schmidt Eva-Madeleine , Bahmanian Nasimeh , Yazdi Sina H. N. , Farahi Fahima , Sancho-Escanero Luisa , Menninghaus Winfried 
Published: May 2023

AbstractEkman famously contended that there are different channels of emotional expression (face, voice, body), and that emotion recognition ability confers an adaptive advantage to the individual. Yet, still today, much emotion perception research is focussed on emotion recognition from the face, and few validated emotionally expressive full-body stimuli sets are available. Based on research on emotional speech perception, we created a new, highly controlled full-body stimuli set. We used the same-sequence approach, and not emotional actions (e.g., jumping of joy, recoiling in fear): One professional dancer danced 30 sequences of (dance) movements five times each, expressing joy, anger, fear, sadness or a neutral state, one at each repetition. We outline the creation of a total of 150, 6-s-long such video stimuli, that show the dancer as a white silhouette on a black background. Ratings from 90 participants (emotion recognition, aesthetic judgment) showed that intended emotion was recognized above chance (chance: 20%; joy: 45%, anger: 48%, fear: 37%, sadness: 50%, neutral state: 51%), and that aesthetic judgment was sensitive to the intended emotion (beauty ratings: joy > anger > fear > neutral state, and sad > fear > neutral state). The stimuli set, normative values and code are available for download.