bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taurolidine/Heparin Lock Solution and Catheter-Related Bloodstream Infection in Hemodialysis
Authors: Agarwal Anil K. , Roy-Chaudhury Prabir , Mounts Phoebe , Hurlburt Elizabeth , Pfaffle Antony , Poggio Eugene C. 
Published: September 2023

Background
Catheter‐related bloodstream infections (CRBSIs) are one of the most prevalent, fatal, and costly complications of hemodialysis with a central venous catheter (CVC). The LOCK IT-100 trial compared the efficacy and safety of a taurolidine/heparin catheter lock solution that combines taurolidine 13.5 mg/ml and heparin (1000 units/ml) versus heparin in preventing CRBSIs in participants receiving hemodialysis via CVC.

Methods
LOCK IT-100 was a randomized, double-blind, active-control, multicenter, phase 3 study that enrolled adults with kidney failure undergoing maintenance hemodialysis via CVC from 70 US sites. Participants were randomized 1:1 to taurolidine/heparin catheter lock solution or heparin control catheter lock solution (1000 units/ml). The primary end point was time to CRBSI as assessed by a blinded Clinical Adjudication Committee. Secondary end points were catheter removal for any reason and loss of catheter patency. On the basis of a prespecified interim analysis, the Data and Safety Monitoring Board recommended terminating the trial early for efficacy with no safety concerns.

Results
In the full analysis population (N=795), nine participants in the taurolidine/heparin arm (n=397; 2%) and 32 participants in the heparin arm (n=398; 8%) had a CRBSI. Event rates per 1000 catheter days were 0.13 and 0.46, respectively, with the difference in time to CRBSI being statistically significant, favoring taurolidine/heparin (P < 0.001). The hazard ratio was 0.29 (95% confidence interval, 0.14 to 0.62), corresponding to a 71% reduction in risk of CRBSIs with taurolidine/heparin versus heparin. There were no significant differences between study arms in time to catheter removal for any reason or loss of catheter patency. The safety of taurolidine/heparin was comparable with that of heparin, and most treatment-emergent adverse events were mild or moderate.

Conclusions
Taurolidine/heparin reduced the risk of developing a CRBSI in study participants receiving hemodialysis via CVC compared with heparin with a comparable safety profile.

Clinical Trial registry name and registration number
Study Assessing Safety & Effectiveness of a Catheter Lock Solution in Dialysis Patients to Prevent Bloodstream Infection, NCT02651428.
UDN-like disease in spawners of salmonid fishes from the Rega, Parsęta, Wieprza, and Słupia rivers in 2009-2012
Authors: Kazuń Barbara , Terech-Majewska Elżbieta , Grudniewska Joanna , Kazuń Krzysztof 
Published: September 2023

Abstract
Since 2007 in Poland, skin lesions have been observed in salmon (Salmo salar L.) and sea trout (Salmo trutta L.) entering Pomeranian rivers to spawn. The clinical picture of affected fish resembled ulcerative dermal necrosis (UDN), a disease of unknown etiology affecting mainly the scalps of wild salmonids. The aim of the 2009-2012 study was to determine with microbiological tests the etiological agent of the skin lesions observed in salmonids entering the Pomeranian rivers. During the study, a total of 13 species of Gram-negative bacteria belonging mainly to the Yersiniaceae, Enterobacteriaceae, and Pseudomonadaceae families were isolated and identified from the skin and kidneys of diseased fish. The Gram-positive bacteria isolated were aerobic, hemolytic granules of the genus Streptococcus. Mycological examinations on damaged fish body surfaces revealed yeasts of the genus Rhodotorula and fungi of the family Saprolegniaceae. The results of our study did not permit us to identify unequivocally the direct cause of the fish diseases analyzed since all the bacteria isolated during the study are normally found in aquatic environments. Some of the isolated bacteria identified were assumed to be potentially pathogenic to fish. The fungal infections observed were probably secondary and only exacerbated ongoing disease processes.
First record of stone moroko (Pseudorasbora parva), an invasive alien fish species, in water bodies of urban green areas in Poland
Authors: Wróblewski Paweł , Maciaszek Rafał , Kasprzak Robert 
Published: September 2023

Abstract
Invasive alien species are currently a major ecological problem. One such species is stone moroko, Pseudorasbora parva (Gobionidae), which has only been found to date in natural or agricultural water bodies (lakes, rivers and streams, carp ponds). Therefore, the current study is the first description of stone moroko in urban green areas (Warsaw, Poland). The fish were caught with a hydrobiological net. Four catches were conducted in ponds located in Morskie Oko Park (pond 1) and the Saxon Garden (pond 2) – two in fall and two in the spring, while two spring catches were conducted in Dolinka Służewska Park (stream). The population in pond 2 apparently survived the winter, and the fish caught in June displayed visible signs of sexual dimorphism and were significantly larger (average body mass: 1648 ± 1123 mg; range: 460–6090 mg) than those caught in the pond in the two fall samplings (404 ± 122 mg; 154–729 mg). After recording substantial numbers of specimens in the fall, no fish were caught in pond 1 during either of the spring catches, while only a few moroko were caught in the stream in April (1212 ± 869 mg; 454–2901 mg) and none were caught in June. Throughout the study, 59 specimens were caught in pond 1, 74 in pond 2, and 7 in the stream.
Cognitive and/or Depressive Disorders in the Elderly with Type II Diabetes Mellitus Associated with Hypertension
Authors: Sichim Ada Diana , Gurgas Leonard 
Published: September 2023

Abstract
Type 2 diabetes mellitus is a significant public health problem due to its increasing prevalence, being considered a major risk factor for cardiovascular diseases, thus being an important cause of morbidity and mortality globally. NICE (The UK’s National Institute for Excellence in Health and Care) states that people diagnosed with diabetes (both type 1 and type DZ 2) have a three times higher risk of being diagnosed with depression compared to those who do not have diabetes. Studies on the association of diabetes mellitus in the elderly and neurocognitive disorders have highlighted the increased incidence of dementia in this type of patient, the latter representing a risk factor for the development of strokes. The purpose of the study: to study the presence of neurocognitive dysfunction and the presence of depression in patients who simultaneously present type 2 diabetes mellitus and hypertension, and the correlations between clinical-psychiatric indicators (MMSE score and GDS-15 score) and paraclinical indicators (blood glucose level, HbA1c, total cholesterol, triglycerides, HDL- and LDL-cholesterol), as well as blood pressure values at admission, during hospitalization and at discharge. 120 patients with type 2 diabetes mellitus and HTA were examined, who followed the treatment at the National Institute of Geriartry and Gerontology “Ana Aslan” in Bucharest, registered between April 2021 and April 2022.
Conclusions: According to the data exposed, it can be stated that there is a high probability of the development of cerebral suffering, which can generate cognitive decline of various stages of severity, in decompensated diabetic patients.
High Concentrations of Uranium, Barium, and Lead in Cancer Patients and Healthy Controls in the Malwa Region of Punjab, India
Authors: Bjørklund Geir , Pivina Lyudmila , Semenova Yuliya 
Published: September 2023

Abstract
Background: Anthropogenic risk factors contribute worldwide to an unfavorable environmental situation, which in the population can lead to cancer and other environmental-related diseases. Heavy metals accumulate in tissues and affect human health.
Objectives: This review evaluates data for the possible role of uranium (U), barium (Ba), and lead (Pb) in the cancer development in people living in the Malwa Region of Punjab, India.
Methods: A literature search was performed using the databases PubMed, Google Scholar, and Scopus. Publications in English were included. Preference was given to studies of high methodological quality (systematic reviews and surveys of studies of various designs). The results of cross-sectional studies were taken into account.
Discussion: A study has shown that cancer patients in the Malwa region of Punjab, India have unexpectedly high concentrations of U, Ba, and Pb in hair. We hypothesize that higher hair concentrations of U and other bone-seeking elements in hair of cancer patients may be due to the release of these elements from the skeleton, partly because of the patients age (following the menopause in women) and partly due to disease factors such as bed rest, bone metastases, and enhanced glucocorticoid secretion.
Conclusions: Further research is needed to distinguish the effect of age on bone-seeking elements from real disease associations, regardless of the relationship with the pathology is a causal one or not.
Neurovascular Complications of Distal Humerus Fractures in Children
Authors: Valcu Alexandru , Obada Bogdan , Manac Iulian 
Published: September 2023

Abstract
Introduction: Distal humerus fractures represents a common pathology in paediatric traumatology that can result in neurovascular injuries, which can be serious and require prompt medical attention. Most common complications noted are Brachial Artery Injury and Median Nerve Injury.
Objective: To determine the total number and frequency of neurovascular complications in distal humerus fractures on a period of 6 years in County Emergency Hospital of Constanta.
Material and methods: A cohort study was conducted in patients under 16 years old from 2017 to 2022. Children with pathologic fractures were excluded from this study.
Results: We diagnosed 9 patients out of 165 with nerve injuries, out of which 6 (3.6%) had Median Nerve Injury and 2 (1.2%) had Ulnar Nerve Injury, mostly in children aged 10 or less. We identified 4 (2.4%) children with brachial artery injury.
Conclusions: It is important for healthcare providers to carefully assess and monitor patients with humerus supracondylar fractures to identify and manage any potential complications. Treatment may involve immobilisation, closed reduction or surgical interventions depending on the severity of the fracture and associated complications.
Portraying Trawl Fishery in Albanian Waters: Case Study from the Sarandë Area (Southern Albania)
Authors: Bakiu Rigers , Gurma Marthjon , Moutopoulos Dimitrios K. 
Published: September 2023

Abstract
The current study provides valuable insight into the trawl fishery operating in southern Albanian waters via an integrated approach based on high-frequency onboard monitoring trawl vessels and on-site interviews with local fishers. Multivariate analyses of the composition of species landings or economic revenue revealed groups that, depending on the group, were distinguished by improved fisheries landings and economic efficiency. The majority of the catch consisted of a variety of demersal and small- and medium-sized pelagic species, confirming the Adriatic Sea's multispecies nature. Target species identified in terms of catches and revenue imply a systematic tactic over a long period of time, and incidental catches are equally important in terms of overall group similarity. The identification of target species groups may be useful in assessing the current sampling stratification schemes.
Resilience Mechanisms of the European Trade Network During the Pandemic
Authors: Manafi Ioana , Huru Dragos , Dobre Florin , Capbun Andreea Gabriela , Roman Mihai Daniel 
Published: September 2023

Abstract

Subject and purpose of work:
The economic crisis generated by the COVID-19 pandemic was fundamentally different from those of the past, with unforeseen implication on supply chains and European trade. As the literature regarding the pandemic is vast bibliometric techniques were used to find the most influential themes and authors. The aim of this paper is to test if cascading failure is possible when shocks arise in European trade.

Materials and methods:
To characterise the European commerce, network analysis was employed using Eurostat data of imports and exports in the following years: 2018, 2019 and 2020. Trade value indices were also used to characterised European trade during the pandemic and Enterprise Survey run by World Bank for in-depth, cross economies comparisons.

Results:
The results from the network analysis characterise the compactness of the network, showing that the European trade network is characterised by robustness.

Conclusions:
Cascading failure has a low probability of occurrence.
Growth and Trends of Agriculture: Food Grain Production and Area in India
Authors: Rani Mamta 
Published: September 2023

Abstract

Subject and purpose of work:
The purpose of this study is to determine the area and production status of food grains in India.

Materials and methods:
The current study was conducted using secondary data that was gathered from numerous sources, including the Statistical Abstract of Haryana, and the Economic Survey. Between 1991-1992 and 2021-2022, the area and production of food grains have seen a compound growth rate.

Results:
The results show a fluctuating trend in area and production during the years 1991-92 to 2021-22. For the study period, the mean average of the production and area of food grains was estimated.

Conclusions:
Agriculture is still a significant sector for the economy from the p erspectives of self-sufficiency and employment, despite the sector’s diminishing GDP proportion over time. The trajectory and expansion of Gross Value Added (GVA), investments in agriculture, and food grain crops were all examined in this article.
Unusual Changes in the U.S. Treasury Security Market During the Fourth Round of Quantitative Easing
Authors: Allen Kyle D. , Hein Scott E. 
Published: September 2023

Abstract
The Covid-19 Pandemic and policy response rattled the US Treasury markets. Conventional US Treasuries, inflation adjusted US Treasuries, and the relationship between the two developed in ways such that ignoring changes in real interest rates yielded distorted inflation expectations estimates. Since the beginning of the pandemic, monetary policy kept nominal rates low and close to zero, but positive. Real rates, on the other hand, became increasingly negative. The relationship between the two market rates became negatively correlated, and distorted because of the fourth round of quantitative easing, along with the Fed preventing nominal yields from turning negative. Federal Reserve actions during the Covid-19 pandemic drove a larger wedge between nominal interest rates and real interest rates in the inflation adjusted market.
Raising Interest Rates for Improving Income
Authors: Peña Guillermo 
Published: September 2023

Abstract
This paper illustrates a case where an increase of the interest rates improves the economic activity and reduces income inequality. This theoretical exercise deals with a simple model of disequilibrium with accountant identities of budget constraints. In addition, and following previous models, the effect of the COVID-19 shock is considered, by reflecting asymmetric repercussions that increase income inequality. A simple empirical exercise confirms some of the previous results. The proposed explanation is that, for the euro area, this shock has affected more middle-income households such as the retailers harmed by the compulsory lockdown who have increased their debts.
The Number and Authority of the Ecumenical Councils in the Second Helvetic Confession
Authors: Pásztori-Kupán István 
Published: September 2023

Abstract
Whilst Bullinger’s CHP accepts the decisions of the first four ecumenical councils, no description has been produced concerning their criteria. Based on the common features of Nicaea, Constantinople, Ephesus and Chalcedon, the Apostles’ Council of Jerusalem would fit the pattern, with one exception: it had neither been convened nor supervised by secular rulers. Why did the strongly Bible-oriented Reformers fail to ‘renumber’ the ecumenical councils starting with the one in Jerusalem, as they did e.g. with the Decalogue or the sacraments? Apparently, they acquiesced in the already established state of affairs to appease the contemporary secular powers, whilst preserving Chalcedon’s Christological and soteriological heritage.
The Papacy: A Philosophical Case
Authors: Sijuwade Joshua 
Published: September 2023

Abstract
This article aims to provide a philosophical case for the veracity of the doctrine of the papacy. This specific case will be presented as an a priori argument that will be formulated in light of the work of Richard Swinburne and Linda Zagzebski—which, in combination, will provide us with grounds for believing in the veracity of the papacy from a philosophical perspective, and thus help to further bolster up the historical arguments that are usually brought in support of the veracity of the doctrine.
Divided by the Translation, But United in the Concept? The Word Study of מִכְתָּם
Authors: Chia Philip Suciadi 
Published: September 2023

AbstractThe Hebrew word מִכְתָּם creates a problem because the meaning is controversy. The Hebrew lexicon, BDB (1906) and TWOT lexicon (2003), confirm this difficulty, saying, “the meaning of this word is unknown.” PONS Kompaktwörterbuch Althebräisch (2015) records that this word is untranslated, while the other sources translate as song, prayer, or epigram. Allen P. Ross (2012:48), a Hebrew scholar, indicates that its meaning is disputed. Ibn Ezra (Strickman 2009:112) interprets that this word refers to a very precious Psalm. He compares withketem pazor the finest gold in Song of Songs 5:11 because both words are derived from the same root. This perplexity also occurs in ancient texts as they differ in their translations. This article, therefore, attempts to study and solve this dilemmatic word in ancient texts with textual criticism of its methodology. This study argues that the word מִכְתָּם is not only different in translation, but also the concept in ancient texts.
Effect of Storage Period on Acid Value and Sensory Attributes of Puffed Wheat Grains ‘Badyrak Vanilla’ and ‘Badyrak with Whey’
Authors: Konkubaeva Nurzat , Kulmyrzaev Asylbek , Deydiev Anarseit , Radenkovs Vitalijs , Galoburda Ruta 
Published: September 2023

Abstract
Puffed grains made from whole wheat, corn or rice grains are ready-to-eat breakfast cereals that do not require additional preparation. Two recipes for puffed grain coatings were developed in the previous studies. Sunflower oil was used in the coating, which may affect storage stability. Due to lipid hydrolysis, free fatty acids may be released, causing rancid off-flavour. The aim of this study was to determine the changes in the acid value of lipids and sensory attributes of sweet-coated puffed wheat grains ‘Badyrak vanilla’ (BV) and ‘Badyrak with whey’ (MC) depending on temperature during their eight-month storage. The products were packaged in metallised polypropylene pouches, 30 g each. The acid value was studied monthly at different storage temperatures (20 ± 2 °С and 4 ± 2 °С). In puffed wheat grain products, 65% of fatty acids are polyunsaturated, 25% monounsaturated, and 10% saturated. The high proportion of unsaturated fatty acids over saturated makes oil more susceptible to oxidation. Literature studies and sensory evaluation of puffed wheat grains allowed setting a limiting acid value at 4.0 mg KOH g−1 lipids. The increase in acid value was storage temperature dependent. Thus, the acid value exceeded the established limit in the fifth month for MC and the sixth month for BV when stored at 20 ± 2 °С. At the same time, noticeable changes in puffed wheat grain flavour were observed. The temperature coefficient (Q10) for MC was 2.0, whereas for BV it was 1.5, indicating that the acid value increase in MC was more affected by temperature than that in BV.
Evaluation of Fatty Acid Composition in Amaranth Pasta Developed for a Vegan Diet
Authors: Marisheva Alla , Beitane Ilze 
Published: September 2023

Abstract
Consumers’ growing demand for vegan products creates a need for new nutrient-dense products. Amaranth seeds are characterised as a nutritious product due to the content of proteins, fats, etc. Considering the high-quality fats and their amount in amaranth seeds, the aim of this study was to analyse the profile of fatty acids in amaranth pasta which was developed for a vegan diet. Seven samples: amaranth, amaranth-oat, and amaranth-buckwheat pasta in different ratios, were analysed in the study. The preparation of samples for analysis was carried out according to LVS EN ISO 6498:2012; fatty acid composition was determined using the GC/MS analytic method.
The highest total fat content was determined in the amaranth pasta – 5453.62 mg 100 g−1 of product, followed by the amaranth-oat pasta (85%/15%) – 4988.14 mg 100 g−1 of product and amaranth-oat pasta (70%/30%) – 4772.93 mg 100 g−1 of product. In the developed pasta samples, over 70% of total fat was unsaturated fatty acids and more than one-third of total fat was PUFA. The highest PUFA/SFA ratio was determined for amaranthoat pasta (70%/30%), amaranth-buckwheat pasta (85%/15%), and amaranth-buckwheat pasta (70%/30%). Quantitatively, the essential fatty acids were oleic acid, linoleic acid, and palmitic acid. The triterpene squalene was detected with a probability of 90% in all amaranth, amaranth-oat, and amaranth-buckwheat pasta samples. The developed pasta for a vegan diet contains good-quality fat.
Physicochemical Quality Evaluation of Fresh-Cut Rosemary (Rosmarinus officinalis L.) Packed and Stored in Biodеgradаblе Film
Authors: Augšpole Ingrīda , Sivicka Irina , Muižniece-Brasava Sandra 
Published: September 2023

Abstract
Fresh-cut herbs satisfy consumer demand owing to the convenience of buying them in food shopping malls as quickly accessible products. Food packaging has an important role in the food industry nowadays, because it helps to preserve the quality of fresh-cut food products at the production and sales sites and provides safety during storage. The aim of this research was to evaluate the quality changes of fresh-cut rosemary packed and stored in biodegradable film packaging. Rosemary has been packed in several materials – two biodegradable packaging materials, NatureFlexTM NVS INNOVIA film, Nature Works® PLA P-360 containers with hermetically pressed PLA cap and “breathable” conventional BOPP PropafilmTM P2GAF film. The samples were analysed over time at 0, 3, 5, 8, 10 and 12 days of storage at a temperature of +5 ±1 °C in terms of physicochemical quality: O2 and CO2 concentration, mass loss, pH, content of soluble solids (ºBrix) and tested sensory evaluation. The analysis of the obtained results showed that the cellulose based biodegradable NatureFlexTM NVS INNOVIA film was a good way to prolong the storage time of fresh-cut rosemary and ensure sensory quality and high physiochemical quality during the preservation period.