bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a reliable detection of arachnophobia: subjective, behavioral, and neurophysiological measures of fear response
Authors: Landová Eva , Rádlová Silvie , Pidnebesna Anna , Tomeček David , Janovcová Markéta , Peléšková Šárka , Sedláčková Kristýna , Štolhoferová Iveta , Polák Jakub , Hlinka Jaroslav , Frynta Daniel 
Published: June 2023

IntroductionThe administration of questionnaires presents an easy way of obtaining important knowledge about phobic patients. However, it is not well known how these subjective measurements correspond to the patient’s objective condition. Our study aimed to compare scores on questionnaires and image evaluation to the objective measurements of the behavioral approach test (BAT) and the neurophysiological effect of spiders extracted from fMRI measurements. The objective was to explore how reliably subjective statements about spiders and physiological and behavioral parameters discriminate between phobics and non-phobics, and what are the best predictors of overall brain activation.MethodsBased on a clinical interview, 165 subjects were assigned to either a “phobic” or low-fear “control” group. Finally, 30 arachnophobic and 32 healthy control subjects (with low fear of spiders) participated in this study. They completed several questionnaires (SPQ, SNAQ, DS-R) and underwent a behavioral approach test (BAT) with a live tarantula. Then, they were measured in fMRI while watching blocks of pictures including spiders and snakes. Finally, the respondents rated all the visual stimuli according to perceived fear. We proposed the Spider Fear Index (SFI) as a value characterizing the level of spider fear, computed based on the fMRI measurements. We then treated this variable as the “neurophysiological effect of spiders” and examined its contribution to the respondents’ fear ratings of the stimuli seen during the fMRI using the redundancy analysis (RDA).ResultsThe results for fear ranks revealed that the SFI, SNAQ, DS-R, and SPQ scores had a significant effect, while BAT and SPQ scores loaded in the same direction of the first multivariate axis. The SFI was strongly correlated with both SPQ and BAT scores in the pooled sample of arachnophobic and healthy control subjects.DiscussionBoth SPQ and BAT scores have a high informative value about the subject’s fear of spiders and together with subjective emotional evaluation of picture stimuli can be reliable predictors of spider phobia. These parameters provide easy and non-expensive but reliable measurement wherever more expensive devices such as magnetic resonance are not available. However, SFI still reflects individual variability within the phobic group, identifying individuals with higher brain activation, which may relate to more severe phobic reactions or other sources of fMRI signal variability.
Effects of aquatic exercises on physical fitness and quality of life in postmenopausal women: an updated systematic review and meta-analysis
Authors: Zhou Wen-Sheng , Mao Su-Jie , Zhang Shi-Kun , Xu Hong , Li Wei-Lu 
Published: June 2023

ObjectiveIn the present systematic review and meta-analysis, we aimed to evaluate and update the effects of aquatic exercise on physical fitness and quality of life (QoL) in postmenopausal women.MethodsThe databases Cochrane Library, PubMed, Web of Science, and MEDLINE were searched for randomized controlled trials (RCTs) on the topic from inception to July 2022. The GetData software was used to extract data from the published images. RevMan5.4 software was used for statistical analysis. Data are expressed as standardized mean difference (SMD) with 95% confidence intervals (CI). I2 index was employed for heterogeneity. Egger's test was used to assess publication bias. We evaluated the methodological quality of included studies using the Physiotherapy Evidence Database scale.ResultsWe included 594 participants in 16 RCTs (19 comparison groups). The results indicated that aquatic exercise can significantly improve lower limb strength (LLS), upper limb strength (ULS), agility, flexibility, and overall QoL. No significant effects were found on aerobic capacity. Subgroup-analysis results indicated that aquatic exercise only significantly improved LLS, ULS, agility, and flexibility in postmenopausal women &lt; 65 years of age. However, aquatic exercise improves the overall QoL both in postmenopausal women &lt; 65 years and ≥ 65 years. Aquatic resistance exercise significantly improves LLS, ULS, agility and flexibility. In addition, aquatic aerobic exercise can effectively increase LLS, and combined aquatic aerobic and resistance exercise can enhance the overall QoL.ConclusionsAquatic exercise can effectively improve physical fitness and overall QoL in postmenopausal women, but has limited effects on aerobic capacity; thus, it is highly recommended in postmenopausal women.
Prevalence of unfavorable outcome in acute poisoning and associated factors at the University of Gondar comprehensive specialized hospital, Gondar, Northwest Ethiopia: a hospital-based cross-sectional study
Authors: Waktola Leta Gemeda , Melese Endalkachew Belayneh , Mesfin Nebiyu , Altaye Kassaye Demeke , Legese Gebrehiwot Lema 
Published: June 2023

BackgroundAcute poisoning is a medical emergency in which the toxic effects occur almost immediately, usually within hours from the time of exposure, and can result from exposure to excessive doses of any chemical. It is the common cause of emergency admission, which may result in morbidity and mortality. There are a lot of factors that are associated with an increased magnitude of mortality and complication. Therefore, this study was carried out to assess the clinical characteristics of patients, unfavorable outcomes of acute poisoning, and associated factors to improve the quality of care, resource utilization, and decrease mortality.ObjectiveThis study aimed to assess the outcome and associated factors among acute poisoning patients at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia (2021).MethodsA prospective follow-up study was conducted from January 2021 to September 2021 at the University of Gondar Comprehensive Specialized Hospital, Gondar, Northwest Ethiopia. Data were collected using a comprehensively organized and pretested interviewer-administered questionnaire. The data were entered using EPI data version 4.6.0 statistical software and then exported to Stata 14 for analysis. The data were analyzed for descriptive statistics. Statistical analysis was performed using bivariate and multivariate logistic regression models to identify factors associated with the unfavorable outcome of acute poisoning. The result is presented in the form of tables, figures, and text using frequencies and summary statistics such as mean, SD, median, IQR, and percentage.ResultA total of 233 patients were included in the study. The prevalence of unfavorable poisoning outcomes in acute poisoning was 17.6% (95% CI: 13.2, 23.1). In the multivariate logistic regression analysis, known chronic medical comorbidities [AOR: 3.846 (1.619, 9.574); value of p: 0.014] and hospital stay of less than 48 h [AOR: 6.57 (2.03, 21.273); value of p: 0.002] were found to be independent factors associated with unfavorable outcomes in acute poisoning.ConclusionThe magnitude of unfavorable poisoning outcomes was high in patients with acute poisoning. Having known medical comorbid illness and short hospital stay of less than 48 h were found to be associated with unfavorable outcomes.
Children’s Internet use and physical and psychosocial development
Authors: Novaković Svetlana , Milenković Sanja , Srećković Marijana , Backović Dušan , Ignjatović Vladimir , Capo Nataša , Stojanović Tamara , Vukomanović Vladimir , Sekulić Marija , Gavrilović Jagoda , Vuleta Katarina , Ignjatović Vesna 
Published: June 2023

IntroductionInternet use (IU) commonly refers to sedentary lifestyle and may be addictive, especially among children. The aim of this study was to investigate the relationship between IU and some aspects of child physical and psychosocial development.MethodologyWe conducted a cross-sectional survey by using a screen-time based sedentary behavior questionnaire and Strengths and Difficulties Questionnaire (SDQ)—among 836 primary school children in the Braničevo District. The children’s medical records were analysed for vision problems and spinal deformities. Their body weight (BW) and height (BH) were measured and body mass index (BMI) was calculated as BW in kilograms divided by BH in meters squared (kg/m2).ResultsThe average age of respondents was 13.4 (SD 1.2) years. The mean duration of daily Internet use and sedentary behavior was 236 (SD 156) and 422 (SD 184) minutes, respectively. There was no significant correlation between daily IU and vision problems (near sightedness, farsightedness, astigmatism, strabismus), and spinal deformities. However, daily Internet use is significantly associated with obesity (p &lt; 0.001) and sedentary behavior (p = 0.01). There was significant correlation between emotional symptoms with total Internet usage time, and total sedentary score (p &lt; 0.001 for both, r = 0.141 and r = 0.132, respectively). There was a positive correlation between the total sedentary score of children and hyperactivity/inattention (r = 0.167, p &lt; 0.001), emotional symptoms (r = 0.132, p &lt; 0.001), and conduct problems (r = 0.084, p &lt; 0.01).ConclusionIn our study, children’s Internet use was associated with obesity, psychological disturbances and social maladjustment.
An effectiveness-implementation trial protocol to evaluate PrEP initiation among U.S. cisgender women using eHealth tools vs. standard care
Authors: Izadi Lillee H. , Mmeje Okeoma , Drabo Emmanuel F. , Perin Jamie , Martin Stephen , Coleman Jenell S. 
Published: June 2023

BackgroundThe United States' (U.S.) initiative to End the HIV Epidemic aims to reduce new HIV infections in areas of high HIV prevalence. Despite national efforts to reduce HIV incidence, cisgender women continue to represent approximately one out of every five new HIV diagnoses in the U.S. Taking pre-exposure prophylaxis (PrEP) is an effective HIV prevention strategy; however, PrEP initiation among cisgender women is suboptimal, with only 10% of eligible women receiving PrEP prescriptions in 2019.MethodsWe designed a trial to test the effectiveness of interventions to increase PrEP initiation, while evaluating the implementation strategy (hybrid type II trial) in seven obstetrics and gynecology (OB/GYN) clinics (two federally qualified health centers, three community-based, and two academic) in Baltimore, Maryland. A total of 42 OB/GYN providers will be enrolled and randomized (1:1:1) into one of three clinical trial arms (standard of care, patient-level intervention, or multi-level intervention). Eligible patients of enrolled providers will receive a sexual health questionnaire before their appointment through the electronic health record’s (EHR) patient portal. The questionnaire will be scored in three tiers (low, moderate, and high) to assess HIV risk. Patients at low risk will be offered an HIV test only, while those who score medium or high risk will be included in the clinical trial and assigned to the clinical trial arm associated with their provider. Differences in PrEP initiation, our primary outcome, across the three arms will be analyzed using generalized linear mixed-effect models with logistic regression. We will adjust results for demographic differences observed between arms and examine PrEP initiation stratified by patient’s and provider’s race and ethnicity.Additionally, a comprehensive economic analysis for each intervention will be conducted.DiscussionWe hypothesize that gathering information on sensitive sexual behaviors electronically, communicating HIV risk in an understandable and relatable format to patients and OB/GYN providers, and deploying EHR alerts will increase PrEP initiation and HIV testing.Trial RegistrationThe trial is registered with ClinicalTrials.gov (NCT05412433) on 09 June 2022. https://clinicaltrials.gov/ct2/show/NCT05412433?term=NCT05412433&amp;draw=2&amp;rank=1.
Encapsulation of sugar beet phytoglobin BvPgb 1.2 and myoglobin in a lipid sponge phase system
Authors: Gilbert Jennifer , Christensen Simon , Nylander Tommy , Bülow Leif 
Published: June 2023

Globins are usually associated with oxygen carriage in vertebrates. However, plants also contain similar heme-containing proteins, called phytoglobins (Pgbs). Unlike conventional hemoglobin, these proteins are often linked to nitric oxide metabolism, energy metabolism and redox maintenance under hypoxic and related abiotic and biotic stress conditions. Class I and II non-symbiotic Pgbs (nsPgbs) have different degrees of heme hexacoordination. This involves direct interaction of the distal histidine in the E-helix with the sixth coordination site of the central iron, resulting in increased stability, in contrast to the oxygen storage linked to pentacoordinated globins, such as myoglobin (Mb). Due to their robustness, nsPgbs have substantial potential for various biomedical applications, particularly for iron supplementation. In this study, a class I nsPgb from sugar beet (Beta vulgaris ssp. vulgaris) was encapsulated in a lipid sponge phase system for potential protein delivery purposes and compared to a similar system of Mb containing nanoparticles. Bulk phases and dispersions were made with two lipid compositions (30/45/25 diglycerol monooleate (DGMO)/Capmul GMO-50/sorbitan monooleate (P80) and 28/42/30 DGMO/GMO-50/P80, where the DGMO/GMO-50 ratio was kept constant at 40/60). In addition, buffer effects on protein loading and particle formation were investigated. High concentrations of BvPgb1.2 (60 mg/mL) showed higher aggregation tendencies than Mb but these appeared to be transient. This property could be coupled to the higher isoelectric point (pI) of the BvPgb1.2 (7.85, compared to 6.8 for Mb), which make it more sensitive to small pH changes. In addition, excess protein/leakage was observed with Mb from the nanoparticles when analysed with size exclusion chromatography. This work highlighted the encapsulation efficiency of these proteins, which might be directly linked to difference in iron coordination and therefore, reactivity and lipid peroxidation. The interactions between the bulk phases and dispersion of the hemeproteins are complex, more research is needed to proper elucidate these relations in more detail, in order to facilitate the encapsulation capacity for heme-containing proteins in similar lipid-based systems.
Performances of novel custom 3D-printed cutting guide in canine caudal maxillectomy: a cadaveric study
Authors: Chambers Aidan , Traverson Marine , Neal Shelby , Konala Satyanarayana , Harrysson Ola 
Published: June 2023

IntroductionCaudal maxillectomies are challenging procedures for most veterinary surgeons. Custom guides may allow the procedure to become more accessible.MethodsA cadaveric study was performed to evaluate the accuracy and efficiency of stereolithography guided (3D-printed) caudal maxillectomy. Mean absolute linear deviation from planned to performed cuts and mean procedure duration were compared pairwise between three study groups, with 10 canine cadaver head sides per group: 3D-printed guided caudal maxillectomy performed by an experienced surgeon (ESG) and a novice surgery resident (NSG), and freehand procedure performed by an experienced surgeon (ESF).ResultsAccuracy was systematically higher for ESG versus ESF, and statistically significant for 4 of 5 osteotomies (p &lt; 0.05). There was no statistical difference in accuracy between ESG and NSG. The highest absolute mean linear deviation for ESG was &lt;2 mm and &gt;5 mm for ESF. Procedure duration was statistically significantly longer for ESG than ESF (p &lt; 0.001), and for NSG than ESG (p &lt; 0.001).DiscussionSurgical accuracy of canine caudal maxillectomy was improved with the use of our novel custom cutting guide, despite a longer duration procedure. Improved accuracy obtained with the use of the custom cutting guide could prove beneficial in achieving complete oncologic margins. The time increase might be acceptable if hemorrhage can be adequately controlled in vivo. Further development in custom guides may improve the overall efficacy of the procedure.
Biochemical and Antioxidant Properties as well as Antimicrobial and Antibiofilm Activities of Allium scorodoprasum subsp. jajlae (Vved.) Stearn
Authors: Canli Kerem , Turu Dilay , Benek Atakan , Bozyel Mustafa Eray , Simsek Özcan , Altuner Ergin Murat 
Published: June 2023

In this study, the chemical composition and biological activity of Allium scorodoprasum subsp. jajlae (Vved.) Stearn were investigated for the first time, focusing on its antimicrobial, antioxidant, and antibiofilm properties. A GC-MS analysis was employed to evaluate the composition of its secondary metabolites, identifying linoleic acid, palmitic acid, and octadecanoic acid 2,3-dihydroxypropyl ester as the major compounds in ethanol extract. The antimicrobial activity of A. scorodoprasum subsp. jajlae was assessed against 26 strains, including standard, food isolate, clinical isolate, and multidrug-resistant ones, as well as three Candida species using the disc diffusion method and the determination of the minimum inhibitory concentration (MIC). The extract showed strong antimicrobial activity against Staphylococcus aureus strains, including methicillin-resistant and multidrug-resistant strains, as well as Candida tropicalis and Candida glabrata. Its antioxidant capacity was evaluated using the DPPH method, revealing a high level of antioxidant activity in the plant. Additionally, the antibiofilm activity of A. scorodoprasum subsp. jajlae was determined, demonstrating a reduction in biofilm formation for the Escherichia coli ATCC 25922 strain and an increase in biofilm formation for the other tested strains. The findings suggest potential applications of A. scorodoprasum subsp. jajlae in the development of novel antimicrobial, antioxidant, and antibiofilm agents.
Quelle identité havraise ? Les apports de la nouvelle Histoire du Havre
Authors: Saunier Éric 
Published: June 2023

Pour les historiens, les célébrations sont une opportunité pour faire connaître les acquis de leurs recherches. Par ce biais, ils contribuent à enrichir la réflexion d’une historiographie en incessante évolution. La publication récente de l’ouvrage
Histoire du Havre, paru aux éditions Privat à l’occasion des 500 ans de la fondation de la Cité océane, en constitue une parfaite illustration.
Les Anglais et le sport dans les premières stations balnéaires normandes
Authors: Machemehl Charly , Pécout Christophe 
Published: June 2023

Pionnière des stations balnéaires en France, c’est au début du e que Dieppe se
transforme en terre d’accueil pour villégiateurs fortunés. Quelques décennies plus tard apparaît Deauville, dont le modèle de développement économique se base exclusivement sur le tourisme. Créée ex nihilo, Deauville se transforme structurellement en devenant une véritable ville balnéaire. Aux transformations techniques (raccordement électrique, éclairage public, eau potable…) s’ajoutent la construction d’équipements structurants (gare, port, hôtels, aérodromes) et la réalisation de nombreuses infrastructures dédiées aux loisirs : casinos, hippodromes, golf, tennis, etc. Cette pratique des sports s’inscrit dans l’univers aristocratique et bourgeois, fortement influencé par la gentry anglaise, où l’essentiel de l’activité réside, non pas dans la performance ou la compétition, mais dans une sociabilité sportive autour de valeurs communes : fair-play, courtoisie, élégance, loyauté, etc. De cette prédominance des investissements « sport-loisirs » naît une notoriété sportive, véritable marqueur d’identité touristique.
La biomasse en Normandie, une ressource locale peu connue mais en plein essor !
Authors: Bourdin Sébastien , Jeanne Ludovic , Raulin François 
Published: June 2023

Dans le mix énergétique, toutes les sources d’énergie renouvelables doivent être encouragées. La méthanisation est d’autant plus intéressante qu’elle permet à ses initiateurs une production d’électricité, de gaz ou de chaleur pour des usages locaux. Et pour les collectivités territoriales, les avantages de la méthanisation sont multiples : réalisation d’économies, création de nouvelles filières énergétiques durables et territorialisées, développement de l’emploi. En outre, il s’agit d’associer d’une manière efficace la recherche et l’innovation sociale en créant de la valeur ajoutée dans le
respect de l’environnement. Créer une nouvelle source d’énergie en valorisant les
déchets organiques, c’est surtout limiter la consommation d’énergies fossiles au profit d’une énergie de proximité, alternative et verte. La méthanisation, bien que peu connue encore aujourd’hui, se développe très rapidement en Normandie.
الحلم وأبعاده في بناء القصة القصيرة القصة العراقية القصيرة انموذجا
Authors: د. ثائر محمد الدباغ  
Published: June 2023

لعل من العناصر التي يقوم عليها بناء العمل الادبي عامة والعمل القصصي خاصة
الحلم الذي يشكل حركة التفاعل النصي ومشكلته في مجرى احداث العمل الادبي وبمعنى
آخر انه الغائب او البطل الذي يلون أحداث العمل الادبي بالوان الخلاص المستمدة من
واقع أسطوري او من واقع تاريخي او من واقع ديني او من واقع أجتماعي وغيرها. فأنه
الامل الذي يعبر عن طموحات مجرى الاحداث وصولا الى التفرد على واقع مرير فضلا
عن انه خلاص من تفاعلات نفسية وأزمات فكرية يمر ب بها المجتمع؛ فنتيجة البحث عن
الحلم نتيجة أستأثر بها القاص واستحوذت عليه فأخذت كل اهتمامه فضلا عن الانشغال
بالتراث وتناوله بروح جديدة فقد كان التراث طاقات ابداعية لا تقل أهميته عن سابقها. لقد
شهد موضوع اختيار القصة تحولاً كبيراً في العقد الستيني وما تلاه من القرن العشرين
فبعد أن كان الاهتمام منصباً على الموضوعات الاجتماعية والسياسية والاكتفاء بهما نظرة
واقعية انتقادية. صار الاهتمام بموضوعات تتعلق بالذات الانسانية وتطلعاتها نحو
الخلاص من أزماتها التي رافقت هذه الحقبة؛ لقد حاول القاص البحث عن موضوعات
تهتم بغائب حلم وغالباً مايكون ميتافيزيقياً أو نزوعاً الى التحرر من أسر قيد يتمش في
الاقامة في اماكن خاصة؛ والعيش ضمن اجواء تقليدية فضلا عن أهتمام القاص بمواضيع
تختص بالاغتراب على انه حالة انسانية خاصة. وجد القاص نفسه تدور في منعطفاتها فقد
كان التراث محطة أثيرة وقف عندها طويلاً؛ وابداعاته في هذا المجال تتمثل في الصيغة
الجديدة التي أعطاها له في مجال التقنية؛ فأنه تجاوز الانماط القديمة المتمثلة بالحبكة
القديمة في بداية وعقدة ونهاية الى ابتداع أساليب فنية جديدة وتعد الشعرية التي توصل
اليها القاص تقنية جديدة أعدت متميزا له وسيحاول هذا البحث المتواضع ان يقف عند
موضوع ظاهرة الحلم في بناء القصة القصيرة من خلال ثلاث محاور يتناول المحور
بلاغة اسلوب النقديم والناخير في آيات الجنة والنار في القرآن الكريم
Authors: أ.م.د. طالب عويد نايف  , م. د. أحمد بطل وسيج  
Published: June 2023

حقق أسلوب التقديم والتأخير في آيات الجنة والنار - عبر أنماطه المختلفة
وسياقاته المتتوعة -دلالات ومعاني بلاغية جليلة كالاهتمام ءوالعناية ءوالتشويق،
وغيرهاء وقد تجلى منها بشكل كبير وواضح غرض الاختصاص الذي يؤمن للنفس
المؤمنة ما تصبو إليه من إثبات الأجر والثواب لها على أفعالها الصالحة؛ إضافة إلى
تعريضه بالكقار الذين زلت قدمهم عن الصراط المستقيم .
بلاغة أسلوب التقديم والتأخيرا":

يستقل أسلوب التقديم والتأخير في آيات الجنّة؛ والنار مكانة بلاغيّة عالية
ويكون ظاهرة أسلوبية فريدة تنبه نظر القارئ لهاء فالتقديم والتأخير أداة فعالة لإبراز
هذا الأسلوب المعجزء فكل كلمة قدمت لأمرء وأخّرت أخرى لأمر آخر.

قال سيبويه في كتابه: (كأنّهم يقدّمون الذي بيانه أهم لهم وهم ببيانه أعفى وأن
كانا جميعاً يهمانهم ويعنيانهم)ثا.

وهو - بلا شك- يشتمل على لطائف بلاغية بديعة ومعاني دقيقة تشارك في
إيراز الدلائل، فضلا عن أنها تجلي مغزى المتكلم من وراء استعمال هذا الأسلوب
البلاغي الطريف.

وقد أشار الزركشي إليه بالقول: (هو أحد أساليب البلاغة فإنهم أتوا به دلالة
على تمكنهم في الفصاحة وملكتهم في الكلام؛ وانقياده لهم؛ وله في القلوب أحسن موقع؛