bluuebunny/crossref_metadata_2025_split huggingface dataset:
RECENT DEVELOPMENTS IN SYNTHETIC METHODS AND PHARMACOLOGICAL ACTIVITIES OF QUINAZOLINONE DERIVATIVES: A REVIEW
Authors: Meftah Omar N. , Ali Ahshan , Ali G. Al-kaf  
Published: January 2025

This review article offers A brief overview of the most current advancements in synthesis methods and with regard to the pharmacological effects of quinazolinone derivatives. A heterocyclic hybrid quinazolinone having the chemical formula C8H6N2O. It is composed of rings that have been fused together i.e benzene and pyrimidine. The production of quinazolinone derivatives can be accomplished using a variety of methods, such as the Aza-diels-alder reaction, Aza-witting reaction, reaction aided by microwaves, metal-mediated synthesis, palladium-catalyzed reaction, copper-catalyzed reaction, ultrasound-promoted reaction, oxidative cyclization, reagent refluxing, one-pot synthesis, and aqueous media. This review paper included a wide spectrum of pharmacological activities, including a wide range of antibacterial, anti-inflammatory, and analgesic properties of quinazolinone derivatives as well as anti-cancer and anti-oxidant properties were covered in this study.

Peer Review History:
Received 15 October 2024; Reviewed 7 November; Accepted 21 December; Available online 15 January 2025
Academic Editor: Dr. Iman Muhammad Higazy, National Research Center, Egypt, imane.higazy@hotmail.com
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
POSTERIOR SCLERITIS: REVIEW OF LITERATURE AND FIRST CASE REPORT FROM YEMEN
Authors: Essam Yahiya Al-shamahi  , Sameha A. Al-Eryani  , Emad Hassan Al-Shamahi  , Nawal Mohammed Al-Hababi  , Nashwan Yahya A Al-Shamahi  , Hassan Abdulwahab Al-Shamahy  
Published: January 2025

A rare inflammatory eye illness that involves the posterior regions of the sclera. Posterior scleritis is very rare in children and more common in women. Ocular pain, headaches, and vision loss are some of its frequently vague clinical manifestations. Rheumatic conditions including systemic lupus erythematous (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis and rheumatoid arthritis (RA) are frequently linked to the scleritis pathogenesis. A comprehensive clinical eye exam is necessary to diagnose posterior scleritis because it can mimic many other ocular disorders. Laboratory tests may reveal underlying systemic disorders, such as rheumatic disease and inflammatory markers. A precise diagnosis is aided by imaging, such as magnetic resonance imaging (MRI) and B-scan ultrasonography. Treatment includes non-steroidal anti-inflammatory drugs (NSAIDs), topical corticosteroids for moderate disease, and systemic corticosteroids for severe disease. For refractory instances, biologic therapy has grown in importance. To treat this potentially blinding condition, a multidisciplinary strategy combining rheumatology and ophthalmology is essential. This case report focuses on a 9-year-old boy who has posterior scleritis and no history of rheumatic disorders or other infections or non-infectious diseases.

Peer Review History:
Received 6 September 2024; Reviewed 8 November; Accepted 21 December; Available online 15 January 2025
Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.5/10
REVIEW ON CELLULAR SIGNALING, GROWTH FACTORS, AND MECHANICAL STIMULUS IN NERVE REGENERATION
Authors: Ezegbe Chekwube Andrew  , Amarachi Grace Ezegbe  
Published: January 2025

The nervous system consists of the autonomous and peripheral. Injury on the peripheral nerve which occurs due to trauma, accident and other associated factors always results in a huge loss of both the motor and sensory functions. The injured nerves can be successfully restored although it requires a lot of molecular response in order to rebuild the functional axons. When this is achieved, the damaged nerve can accurately connect with their original targets. The complete recovery of PNI has not been optimized. Exogenous growth factors (GFs) are a new therapeutic strategy that can be used in nerve regeneration. The mechanism of action of growth factor is based on the ability to activate the signaling cascades via binding to the individual receptors in order to exert the multiple effects and restore the neuron and tissue regeneration. Although the GFs are limited by their short half-life and rapid deactivation. The use of nerve conduits has been able to reduce these limitations. The nerve conduits have been good biocompatibility and biofunctionality properties.

Peer Review History:
Received 14 September 2024; Reviewed 18 November 2024; Accepted 23 December; Available online 15 January 2025
Academic Editor: Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, drmmziqbal@gmail.com
Average Peer review marks at initial stage: 6.5/10
Average Peer review marks at publication stage: 7.5/10
Legal Solutions for Domestic Violence in Unregistered Marriages in Indonesia: Integrating Maqāṣid al-sharī’ah
Authors: Akmal Andi Muhammad , Mundzir Chaerul , Asti Mulham Jaki , Abbas Rahmawati , Mustafa Zulhas'ari 
Published: January 2025

This research investigates the legal protection available for domestic violence (KDRT) victims within unregistered marriages (nikah siri) in Indonesia. It assesses the difficulties arising from the lack of formal recognition for these marriages and evaluates how Maqāṣid al-sharī’ah principles can improve legal protection and fill existing gaps in Indonesian law. The study proposes integrating Indonesian marriage law principles with national frameworks to enhance victim protection. A qualitative approach is used, including descriptive analysis of legal documents, case studies, and jurisprudential interpretations. Data were gathered through literature reviews, document analysis, and interviews with legal experts. The focus is on how Maqāṣid al-sharī’ah principles apply to Indonesian domestic violence laws and the role of itsbat nikah in providing legal remedies. Findings indicate that Indonesia's current legal system inadequately supports victims of unregistered marriages, creating significant barriers to justice and protection. The research underscores that Maqāṣid al-sharī’ah ’s focus on safeguarding life and lineage can form a solid basis for legal reforms. Itsbat nikah is identified as a key solution for officially recognizing these marriages and enhancing legal safeguards. This research is distinctive in merging Maqāṣid al-sharī’ah with Indonesian law, presenting a fresh perspective on improving legal protection for victims in unregistered marriages. By aligning Islamic principles with modern legal practices, the study offers a framework to better support and protect victims. The study's implications suggest that integrating Maqāṣid al-sharī’ah into legal reforms could strengthen protections and foster a more inclusive legal system.
Educação financeira em livros didáticos
Authors: Oliveira Wellington Moisés de , Mazzi Lucas 
Published: January 2025

No início do século XXI, com o Financial Education Project, elaborado pela Organização para a Cooperação e Desenvolvimento Econômico (OCDE) e coordenado pela Comissão de Mercados Financeiros e de Seguros e pela Comissão de Pensões Privadas, o interesse em educar financeiramente os indivíduos foi ganhando espaço em diversas esferas da sociedade, chegando no Brasil, com mais impacto, no ano de 2010. Mais recentemente, por meio de reformas curriculares, como a homologação da Base Nacional Comum Curricular, em 2018, a Educação Financeira ganha destaque no ambiente escolar, tornando-se, em especial, um tópico a ser inserido nos Livros Didáticos brasileiros. A fim de compreender quais discursos são produzidos e perpetuados em situações matemáticas, a partir de compreensões de Educação Financeira produzidas no âmbito da Educação Matemática, este artigo se preocupa em analisar uma coleção de Livros Didáticos de Matemática, aprovada no Programa Nacional do Material e do Livro Didático de 2020, referente aos Anos Finais do Ensino Fundamental. Para dar conta desse propósito, propomos transformar alguns exercícios matemáticos em potentes cenários reflexivos. Apoiados em uma abordagem qualitativa e assumindo as preocupações da Educação Financeira em uma perspectiva crítica, identificamos que o discurso predominante nos Livros Didáticos reforça a lógica neoliberal e que os episódios nos quais a Educação Financeira pode ser enxergada, frequentemente, estão reduzidos a conceitos da Matemática Financeira. No entanto, entendemos que tais episódios podem ser transformados em ambientes reflexivos, os quais, por sua vez, podem contribuir para uma formação mais crítica de nossos estudantes dos Anos Finai do Ensino Fundamental.
Validity and Practicality: Study of E-Poster Development to Improve Environmental Literacy
Authors: Yovita Yovita , Berlian Mery , Sukor Nur Suhaidah , Syafaren Alaniyah , Yusra Nelly 
Published: January 2025

The advancement of Era 4.0 technology has shifted the way humans think and work which were faster, more efficient, and effective in various sectors, including in education field. The Universitas Terbuka (UT) is one of university which has been existed for a long time and actively develop learning methods, for both online platforms and independent learning. In this context, it is important to support, develop and evaluate the distance learning system in utilizing all facilities including teaching materials, especially in terms of UT student practicum. This research aimed to increase environmental knowledge which intended to prepare people who understand and willing to overcome environmental problems by developing a QR-Code based E-Poster. This research implemented development research (Research and Development) with the ADDIE development model (Analysis, Design, Develop, Implementation, Evaluation). The results showed that the QR Code-based E-Poster developed had a high level of validity, practicality and effectiveness in increasing environmental literacy. Most of respondents gave positive responses to the use of E-Posters, such as easy to use, good layout, accessible, effective to deliver, clear text presentation, use of QR Codes, attractive color composition, good systematics, and efficiency in conveying information. In assessing the quality of media, the aspects of readability and understanding of concepts were very important, especially in the context of E-Posters. Conceptual reasoning as the respondent's ability to follow and understand the thoughts or concepts conveyed in the E-Poster was a significant factor. Good text comprehension includes ease of reading and understanding the information presented in the texts on E-Poster, Additionally, good language comprehension in this media included the respondent's ability to understand and interpret the information conveyed through the language used in the E-Poster. These findings highlighted the importance aspects in the development of E-Posters as effective learning and communication instruments. Keywords: e-poster, cyber-university pioneer , validity, practicality
ANALYSIS OF TRIGGERING FACTORS OF VIOLENCE IN CHILDREN GENDER-BASED IN BENGKALIS REGENCY
Authors: Roha Muf , Saifunnajar Saifunnajar , Sumarni Titin 
Published: January 2025

This study aims to find out how the forms of gender-based child violence occur in Bengkalis Regency and what are the triggering factors for gender-based child violence in Bengkalis Regency. The method in this study is qualitative descriptive, data collection is carried out through direct interviews with counselors and heads of fields and heads of UPT as well as counselors and psychologists at related institutions, and documentation, namely taking and requesting data on cases of violence that have been handled by UP2 and LK3 in Bengkalis Regency. After data collection and interviews and analysis, it can be concluded that: 1) Forms of gender-based child violence in Bengkalis Regency include sexual intercourse with children, molestation of children, sexual abuse of children, rape of children, domestic violence against children, fights between children, abuse of children, beating of children, neglect or disposal of babies, abuse of children, exploitation of children, morality, bullying against children, children's rights, threats against children, trafficking against children, sodomy against children, illegal logging against children. 2) Factors that trigger gender-based violence against children in Bengkalis Regency include there are still some people who weaken other genders, parenting and family factors, environmental factors, peers, social media or gadgets.
Impact Analysis of The Agribusiness System on The Profit of Beef Cattle Farming in Minahasa Regency, Indonesia
Authors: Osak Richard E.M.F. , Rundengan Meiske L. , Pangemanan Stevy P. 
Published: January 2025

Objective: The research aims to analyze the impact of all subsystems on farmer profits in the beef cattle agribusiness system in Minahasa Regency, Province of North Sulawesi, Indonesia.

Theoretical Framework: Agribusinesses may engage in a various activities related to the production (agro-production), processing (agro-processing/agro-industry), marketing (agro-marketing), and distribution (agro-distribution) of food and fiber products. Agribusiness as a system, including livestock business, cannot be separated from various interrelated components or subsystems starting from upstream components (input sources) to downstream (post-harvest and marketing), as well as supporting institutional components (policies, funding, extension, etc.).

Method: The research used a survey method, with a purposive sampling method. The research was carried out by collecting sample data through interviews and observations based on questionnaires. The data analysis model uses multiple regression analysis, the impact of each subsystem in the agribusiness system on beef cattle farming profit.

Results and Discussion: The research showed that only the downstream subsystem, especially cattle marketing component, has a very significant impact on the beef cattle farming profit. Meanwhile, the upstream subsystem, on-farm subsystem, downstream subsystem and supporting subsystem each has non-significant impact on the beef cattle farming profit. The research results concluded that partially only the downstream beef cattle farming subsystem had a very significant influence on the profit of the beef cattle farming, due to the effectiveness of the blantik system of beef cattle market as local wisdom in Kawangkoan which is the beef cattle production center of Minahasa Regency.

Research Implications: It is recommended for stakeholders and supporting intitutions of beef cattle agribusiness in Minahasa Regency to trans-orient from the traditional agribusiness system (cattle labor orientation) to an agribusiness system oriented, towards cattle as a source of meat to meet domestic demand which is still met by imports relatively high.

Originality/Value: The marketing and processing sector (downstream subsystem), serious attention needs to be paid because it greatly affects the profits of cattle farming and farmers' income. Because this is the main incentive for farmers to increase the population and production of beef cattle to meet the increasing needs of consumers.
Kontakty osób odbywających karę pozbawienia wolności z rodziną i innymi bliskimi. Źródła i uwarunkowania
Authors: Jarzębińska Aneta 
Published: January 2025

Tło: Kontakty osób skazanych z rodziną i innymi bliskimi to ważne zagadnienie z obszaru penitencjarystyki. Uważa się, że tego rodzaju kontakty zmniejszają dolegliwości uwięzienia oraz, że są warunkiem powodzenia resocjalizacji i readaptacji społecznej.
Cel: Celem artykułu jest prezentacja wyników badania na temat tego, z kim z własnego grona rodzinnego i bliskich kontaktują się więźniowie oraz, czy istnieją zależności pomiędzy cechami socjodemograficznymi więźniów a posiadaniem tych kontaktów.
Metodyka- materiał do badań pochodzi z kwestionariuszy ankiety własnej konstrukcji wypełnionych przez 345 osób odbywających karę pozbawienia wolności w jednym z czterech zakładów karnych w Polsce.
Wyniki- Ustalono, że skazane osoby mają kontakt zwłaszcza z następującymi rodzajami źródeł: pasierb, partnerka/partner, przyjaciel z wolności. Po uwzględnieniu wszystkich kontaktów z dziećmi, z pasierbami, z siostrami, z braćmi oraz z przyjaciółmi, których każdy respondent mógł mieć po kilkoro, kolejność źródeł kontaktu zmieniła się i była następująca: partnerka/partner, matka, pasierbowie. Zwrócono uwagę na niski wśród skazanych odsetek kontaktujących się z własnymi dziećmi.
Odkryto, że posiadanie kontaktu z członkami rodzin i bliskimi zależy od płci i wieku respondentów, ich wykształcenia oraz wymiaru zasądzonego wyroku. Niewielkie znaczenie miała natomiast liczba pobytów w izolacji penitencjarnej.
Wnioski – Utrzymanie i rozwój kontaktów osób skazanych z członkami rodzin i bliskimi powinno być centralnym elementem polityki penitencjarnej. Bliskich, o których wiadomo, że są głównym źródłem kontaktu, warto pozyskiwać jako sojuszników w pracy penitencjarnej. Pamiętając o tym, że źródłem wsparcia po wyjściu na wolność jest najczęściej własna rodzina, gdy brak kontaktu z jej członkami, należy zachęcić skazanych do jego zainicjowania, co dotyczy zwłaszcza kontaktu z ojcem i z własnym potomstwem.
Evaluasi Penyelenggaraan Musyawarah Perencanaan Pembangunan Desa Di Desa Mahato Kecamatan Tambusai Utara Kabupaten Rokan Hulu
Authors: Azari Irfan , Yuza Ahmad Fitra 
Published: January 2025

Tujuan dari Penelitian ini adalah untuk mengetahui apa saja yang harus di Evaluasi yang dilakukan terhadap Penyelenggaraan Musyawarah Perencanaan Pembangunan Desa dan untuk mengetahui kendala yang dihadapi dalam proses Penyelenggaraan Musyawarah Perencanaan Pembangunan Desa Di Desa Mahato Kecamatan Tambusai Utara Kabupaten Rokan Hulu. Jika dilihat dari sifat-sifatnya penelitian ini masuk kedalam kelompok penelitian kualitatif. Berdasarkan hasil penelitian yang dilihat dari konteks indikator evaluasi sitem dalam Pelaksanaan Musyawarah pembangunan desa pihak-pihak yang terlibat dalam penyelengaraan musyawarah perencanaan pembangunan Desa merupakan seluruh pihak yang terlibat dalam pemerintahan desa serta masyarakat. Pelaksanaan musyawarah perencanaan pembangunan Desa berjalan dengan baik dan sesuai dengan apa yang seharusnya dilakukan. Masukkan penyelenggaraan musyawarah perencanaan pembangunan berjalan dengan baik serta bermanfaat bagi perencanaan pembangunan untuk mengambil sebuah kesimpulan Musyawarah yang dilakukan akan mendengar pendapat seluruh peserta Serta Penyelenggaraan musyawarah perencanaan pembangunan Desa menghasilkan sebuah kesimpulan tentang Penyelenggaraan musyawarah perencanaan pembangunan yang akan datang. Hasil dari kesepakatan yang diambil dalam musyawarah kemudian dibuat sebagai suatu rancangan pembangunan yang disampaikan kepada camat kemudian setelah itu disampaikan kepada bupati jika diterima kemudian akan di realisasikan pada tahun berikutnya. Kendala yang dihadapi ialah seperti menyatukan perbedaan pendapat yang dimiliki setiap peserta musyawarah. Susahnya untuk mengajak masyarakat berkumpul untuk meminta pendapat agar tidak ada masyarakat yang merasa pendapatnya tidak didengar
Strategi Pengembbangan Kawasan Hutan Kota Bagansiapiapi Oleh Dinas Lingkungan Hidup Kabupaten Rokan Hilir
Authors: Aziah Siti , Febrian Ranggi Ade 
Published: January 2025

Kawasan Hutan Kota Bagansiapiapi memiliki potensi yang sangat menarik dan sangatlah bagus bila mampu memanfaatkan potensi-potensi yang ada, bila dikembangkannya secara professional. Hutan Kota Bagansiapiapi dengan luas lahan lebih kurang 6 Hektar yang terletak di jalan Kecamatan Kabupaten Rokan Hilir , Objek Kawasan Hutan Kota ini ini sudah mulai dikunjungi oleh para pengunjung terutama pada hari libur, hal ini disebabkan oleh fasilitas yang tersedia di objek kawasan hutan kota ini sangat bervariasi dan menarik. Fasilitas tersebut diantaranya 9 unit gazebo, 5 unit rumah pohon, area olahraga jogging ditengah pepohonan serta pepohonan serta arena bermain anak, tetapi masih sangat disayangkan untuk pembangunan WC dan Masjid belum terealisasikan dengan baik. Penelitian ini bertujuan untuk mengetahui strategi apa yang diambil oleh Dinas Lingkungan Hidup Kabupaten Rokan Hilir dalam mengembangkan kawasan hutan kota serta faktor-faktor apa saja yang jadi penghambat dalam proses pengembangan Kawasan Hutan Kota Bagansiapiapi. Penelitian ini menggunakan metode kualitatif dengan teknis analisis SWOT. Teknik pengumpulan data dilakukan dengan cara Wawancara, Observasi Dan Dokumentasi. Hasil penelitian ini yaitu Strategi Pengembangan Kawasan Hutan Kota Bagansiapiapi Oleh Dinas Lingkungan Hidup Kabupaten Rokan Hilir terdapat 4 indikator yaitu Kekuatan, Kelemahan, Peluang dan Ancaman, dari keempat indikator tersebut point yang banyak (kuat) terdapat pada indikator Kekuatan (Strength) artinya Kawasan Hutan Kota Bagansiapiapi ini sudah cukup bagus dalam hal pengelolaannya tetapi mesti harus dibenahi untuk kedepannya agar lebih bagus. Sedangkan faktor penghambat dalam pengelolaan dan pengembangan Kawasan Hutan Kota Bagansiapiapi yaitu terdapat pada sumber daya keuangan (Anggaran) dan juga sarana.
Pelayanan Dalam Pembuatan Akta Kelahiran Keliling (MEPELING) Di Dinas Kependudukan Dan Pencatatan Sipil Kabupaten Kuantan Singingi
Authors: Rahmawati Desi , Syaprianto  
Published: January 2025

Penelitian ini dilakukan pada Dinas Kependudukan dan Pencatatan Sipil (DISDUKCAPIL) Kabupaten Kuantan Singingi. Tujuan penelitian ini adalah untuk mengetahui penerapan inovasi pelayanan publik Dinas Kependudukan dan Pencatatan Sipil Kabupaten Kuantan Singingi yaitu pelayaan pembuatan Akta Kelahiran keliling serta untuk mengetahui faktor pendukung dalam melakukan pelayanan pembuatan akta kelahiran keliling. Penelitian ini dilakukan dengan metode kualitatif dengan teknik pengumpulan data yaitu wawancara, observasi, dan dokumentasi untuk melihat hasil penelitian dan pembahasan. Hasil penelitian ini menunjukan bahwa penerapan inovasi pelayanan akta kelahiran keliling dapat dikatakan belum sesuai dengan kriteria pelayanan yang ditetapkan oleh pasuruman terdiri dari 5 (lima) kriteria pelayanan yaitu: Realibility, Responsiveness, Assurance, Emphaty dan Tangible. Sehingga diperoleh hasil bahwa penerapan inovasi yang dilakukan Dinas Kependudukan dan Pencatatan Sipil Kabupaten Kuantan Singingi yaitu inovasi pelayanan pembuatan Akta Kelahiran keliling memiliki kebaruan inovasi yang dilakukan belum efektif.