bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetically Confirmed Optimal Causal Association of Cerebrospinal Fluid Metabolites With Hemorrhagic Stroke
Authors: Shen Yingjie , Wang Yaolou , Shen Yongze , Zhang Xi , Yu Zhao , Xu Hangjia , Lin Tie , Rong Yiwei , Guo Chunmei , Gao Aili , Liang Hongsheng 
Published: January 2025

ABSTRACTHemorrhagic stroke (HS) mainly includes intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), both of which seriously affect the patient's prognosis. Cerebrospinal fluid (CSF) metabolites and HS showed a link in observational studies. However, the causal association between them is not clear. We aimed to establish the optimal causality of CSF metabolites with HS. Mendelian randomization (MR) was employed to identify associations between CSF metabolites and different sources of HS. Univariable MR and false discovery rates (FDR) were used to identify initial causal associations. Linkage disequilibrium score regression determined genetic correlations. Multiple sensitive analyses ensured the reliability of the results. Multivariable MR and MR Bayesian Model Averaging were used to identify the optimal causal associations. The combined effects of metabolites and HS were assessed by meta‐analyses. Pathway analyses were performed to identify potential pathways of action. Reverse MR was also conducted to identify reverse causal associations. Finally, Corresponding blood metabolites were used to explore the multiple roles of metabolites. We identified 20 CSF metabolites and six metabolic pathways associated with ICH; 15 CSF metabolites and three metabolic pathways associated with SAH. Nineteen and seven metabolites were causally associated with deep and lobar ICH, respectively. CSF levels of mannose (OR 0.63; 95% CI 0.45–0.88; Pcombined = 0.0059) and N‐acetyltaurine (OR 0.68; 95% CI 0.47–0.98; Pcombined = 0.0395) may serve as the optimal exposures for ICH and SAH, respectively. Additionally, CSF ascorbic acid 3‐sulfate levels significantly decrease the risk of deep ICH (OR 0.79; 95% CI 0.66–0.94; p = 0.0065; PFDR = 0.091). Supplemental analysis of blood metabolites suggested multiple roles for CSF and blood N‐formylanthranilic acid and hippurate. There are significant causal associations between CSF metabolites and HS, which provides a further rationale for the prevention and monitoring of ICH and SAH.image
Caregiving Satisfaction, Psychological Distress and Caregiver Burden in Family Caregivers of Dependent Older People: A Longitudinal Study
Authors: López‐Martínez Catalina , Orgeta Vasiliki , Gutiérrez‐Sánchez Belén , Del‐Pino‐Casado Rafael 
Published: January 2025

ABSTRACTBackground and ObjectivesAlthough a substantial amount of research has focused on negative aspects of caregiving, less research has been conducted investigating positive aspects of providing informal care. The aim of this study was to investigate the longitudinal association between caregiving satisfaction and psychological distress in informal carers of dependent older people, and whether this relationship is mediated by caregiver burden.Research Design and MethodsProspective longitudinal study with a probabilistic sample of 332 caregivers of older relatives, with data collected at baseline and at 1‐year follow‐up. We measured caregiving satisfaction, psychological distress, subjective caregiver burden and several covariates (caregivers' sex, age and objective caregiver burden). Data were analysed using generalised estimation equations with multiple imputation. The STROBE checklist was used to support the writing of this document.ResultsAfter controlling for covariates, caregiving satisfaction was significantly negatively associated with lower levels of subjective caregiver burden (B = −0.17, 95% CI: −0.23, −0.11) and emotional distress (B = −0.23, 95% CI: −0.36, −0.11). When subjective burden was included in the model, the relationship between caregiving satisfaction and psychological distress was no longer significant (B = −0.11, 95% CI: −0.23, 0.02), whereas the association between subjective burden and psychological distress remained (B = 0.75, 95% CI: 0.57, 0.92). The Sobel test confirmed these results (p < 0.001), indicating that subjective caregiver burden mediates the relationship between caregiving satisfaction and psychological distress (complete mediation) over time.Discussion and ImplicationsCaregiving satisfaction exerts a longitudinal protective effect on carers' psychological distress via subjective burden. Our findings indicate that interventions aimed at strengthening caregiving satisfaction may play a significant role in maintaining positive mental health outcomes for informal caregivers.
Disease Severity, Illness Perceptions, Depression and Health‐Related Quality of Life in Patients With Heart Failure
Authors: Huang Zehao , Chair Sek Ying 
Published: January 2025

ABSTRACTBackgroundDisease severity negatively affects health‐related quality of life (HRQOL) among people with heart failure (HF). However, the underlying mechanisms remain underexplored. Illness perceptions and depression serve as potential mediators of this relationship, but the evidence supporting this is limited.ObjectiveTo investigate the relationships among disease severity, illness perceptions, depression and HRQOL in people with HF, as well as to explore the mediating roles of illness perceptions and depression in the relationship between disease severity and HRQOL.MethodsPeople with HF were recruited from a tertiary hospital in China between January and May 2023. All the participants were assessed for disease severity, illness perceptions, depression, HRQOL and sociodemographic and clinical characteristics. The mediation analysis was performed using PROCESS macro in SPSS. The STROBE checklist was followed.ResultsThis study recruited 164 subjects. Disease severity had a significant total effect on HRQOL (β = 0.716, 95% CI: 4.475, 12.068). The results showed that illness perceptions mediated the relationship between disease severity and HRQOL (β = 0.172, 95% CI: 0.042, 0.337), accounting for 24.02% of the total effect. However, a significant mediating role of depression in this relationship was not found. Furthermore, we found that illness perceptions and depression sequentially mediated the relationship between disease severity and HRQOL (β = 0.194, 95% CI: 0.005, 0.395), which accounted for 27.09% of the total effect.ConclusionsThe effect of disease severity on HRQOL is sequentially mediated by illness perceptions and depression. Illness perceptions are important predictors of HRQOL. Targeted interventions should be employed to improve illness perceptions, thereby enhancing HRQOL among people with HF.Relevance to Clinical PracticeMedical staff can carefully assess patient's illness perceptions and implement appropriate strategies to enhance these illness perceptions, thereby improving their HRQOL.Patient or Public ContributionNo patient or public contribution.
Miocene climatic fluctuations likely explain the species diversification of Lysionotus (Gesneriaceae) in Pan‐Himalaya
Authors: Huang Jie , Condamine Fabien L. , Han Meng‐Qi , Cai Lei , Nguyen Khang Sinh , Zou Chun‐Yu , Xu Wei‐Bin 
Published: January 2025

AbstractThe Himalayas represent a complex mountain system housing some of the world's richest floras along with a high level of endemism. Among them, Lysionotus (Gesneriaceae) stands out as a small genus (~34 species) that is unexpectedly distributed across southern to eastern Asia. Within this genus, the mountain forests of the south Pan‐Himalaya region emerge as a hotspot of diversity, hosting most epiphytic and endemic Lysionotus species. To explore the origin, evolutionary history and development of the current distribution pattern of Lysionotus, we inferred a highly resolved phylogenetic framework using 649 nuclear genes sourced from transcriptomes for 27 species. We revealed three major clades within Lysionotus with strong support, corresponding to the genus's classification into three sections (sects. Didymocarpoides, Lysionotus, and Cyathocalyx) based on morphological characters. Molecular dating suggests that Lysionotus is likely to have originated in the karst regions of northern Vietnam to southwestern China during the middle Oligocene (28.18 Ma), and then migrated westward to the southern Himalaya regions during the Miocene. The speciation rates of Lysionotus were likely to be positively linked to changes in East Asian monsoons and past temperatures. Notably, epiphytic species of sect. Lysionotus began colonizing the tropical and subtropical forests of the Pan‐Himalaya around the mid‐Miocene Climatic Optimum, coinciding with the transition to long seed appendages. Our findings support that the formation and development of forests in the southern Himalaya, along with paleo‐climate changes and morphological innovations, which probably facilitated the evolution and expansion of the spatial distribution of Lysionotus.
Gender Different Impacts of Muscle Mass and Adipose Tissue on Patients With Hepatocellular Carcinoma Undergoing Surgical Resection
Authors: Lee Pei‐Chang , Cheng Tsung‐Yi , Ho Chun‐Ting , Huang Kuo‐Wei , Chau Gar‐Yang , Huang Yi‐Hsiang , Huo Teh‐Ia , Hou Ming‐Chih , Wu Jaw‐Ching , Su Chien‐Wei 
Published: January 2025

ABSTRACTBackground & AimsBody composition is an objective assessment reflecting nutritional status and is highly gender different. Surgical resection, the standard treatment for early‐stage hepatocellular carcinoma (HCC), is an energy‐consuming major operation that would affect body composition. However, the impacts of body composition on the post‐operative prognosis of HCC are still uncertain. In this study, we aimed to investigate surgery‐related changes in body composition and the impacts on clinical outcomes of HCC after surgical resection distinguished by gender.MethodFrom January 2013 to December 2018, 401 consecutive patients who received surgical resection for HCC in Taipei Veterans General Hospital were retrospectively reviewed. Cross areas of adipose and muscle mass were measured at L3 vertebral level from peri‐operative computed tomography by Slice‐O‐matic software; body composition indices were thus calculated. Factors associated with survivals were analysed.ResultsBody composition indices did not change significantly after surgical resection of HCC in both males and females. Higher pre‐operative intramuscular adipose tissue index (IMATI) (hazard ratio [HR]: 2.059, p = 0.002) and lower ratio of subcutaneous to visceral adipose tissue index (SATI/VATI) (HR: 1.681, p = 0.028) were independent predictors of worse overall survival (OS) in male patients. In females, higher pre‐operative IMATI (HR: 3.053, p = 0.001) was the only body composition‐related factor predicting OS.ConclusionSurgical resection contributed minor changes in body composition in patients with early HCC. Myosteatosis and subcutaneous to visceral fat ratio were survival predictors in male patients, but myosteatosis was the only body composition‐predictor of survival in females.
Semi‐supervised pipe video temporal defect interval localization
Authors: Huang Zhu , Pan Gang , Kang Chao , Lv YaoZhi 
Published: January 2025

AbstractIn sewer pipe closed‐circuit television inspection, accurate temporal defect localization is essential for effective pipe assessment. Industry standards typically do not require time interval annotations, which are more informative but lead to additional costs for fully supervised methods. Additionally, differences in scene types and camera motion patterns between pipe inspections and temporal action localization (TAL) hinder the effective transfer of point‐supervised TAL methods. Therefore, this study presents a semi‐supervised multi‐prototype‐based method incorporating visual odometry for enhanced attention guidance (PipeSPO). The semi‐supervised multi‐prototype‐based method effectively leverages both unlabeled data and time‐point annotations, which enhances performance and reduces annotation costs. Meanwhile, visual odometry features exploit the camera's unique motion patterns in pipe videos, offering additional insights to inform the model. Experiments on real‐world datasets demonstrate that PipeSPO achieves 41.89% AP across intersection over union thresholds of 0.1–0.7, improving by 8.14% over current state‐of‐the‐art methods.
Mind the gap in kidney care: Translating what we know into what we do
Authors: Luyckx Valerie A. , Tuttle Katherine R. , Abdellatif Dina , Correa‐Rotter Ricardo , Fung Winston W. S. , Haris Agnès , Hsiao Li‐Li , Khalife Makram , Kumaraswami Latha A. , Loud Fiona , Raghavan Vasundhara , Roumeliotis Stefanos , Sierra Marianella , Ulasi Ifeoma , Wang Bill , Lui Siu‐Fai , Liakopoulos Vassilios , Balducci Alessandro ,   for the World Kidney Day Joint Steering Committee
Published: January 2025

AbstractHistorically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to target. Similarly, the vast majority of people living with kidney disease are unaware of their condition, because in the early stages it is often silent. Even among patients who have been diagnosed, many do not receive appropriate treatment for kidney disease. Considering the serious consequences of kidney disease progression, kidney failure or death, it is imperative that treatments are initiated early and appropriately. Opportunities to diagnose and treat kidney disease early must be maximized beginning at the primary care level. Many systematic barriers exist, ranging from patient to clinician to health systems to societal factors. To preserve and improve kidney health for everyone everywhere, each of these barriers must be acknowledged so that sustainable solutions are developed and implemented without further delay.
OsLdh7 Overexpression in Rice Confers Submergence Tolerance by Regulating Key Metabolic Pathways: Anaerobic Glycolysis, Ethanolic Fermentation and Amino Acid Metabolism
Authors: Chatterjee Yajnaseni , Tomar Surabhi , Mishra Manjari , Pareek Ashwani , Singla‐Pareek Sneh Lata 
Published: January 2025

ABSTRACTLactate dehydrogenase plays a key role in alleviating hypoxia during prolonged submergence. To explore the function of the OsLdh7 gene in enhancing submergence tolerance, we overexpressed this gene in rice (Oryza sativa cv. IR64) and subjected the transgenic lines to complete inundation. The overexpression lines showed enhanced viability, chlorophyll content and photosystem II (PSII) efficiency compared to wild‐type (WT) plants under stress and recovery conditions. Additionally, these lines exhibited better starch accumulation and reduced reactive oxygen species (ROS) accumulation. Protein−protein interaction studies revealed that OsLdh7 interacts with OsLos2, OsPdc2, OsAlaAT2 and OsAsp2. Under submergence, enhanced enzyme activities of OsLdh7, OsAsp2 and OsAdh1 led to higher NAD+ levels, sustaining anaerobic glycolytic flux and increasing pyruvate, a critical carbon source for amino acid metabolism as well as anaerobic fermentation pathways. Elevated l‐lactate levels resulted in increased activity of OsPdc2, which eventually led to enhanced ethanol production. The overexpression lines also accumulated higher levels of aspartate, glutamate and alanine, crucial for ROS reduction and energy production during recovery. These findings suggest that OsLdh7 overexpression confers tolerance to submergence stress by regulating the important metabolic pathways‐ anaerobic glycolysis, ethanolic fermentation and amino acid metabolism in rice.
Pregnancy Intendedness by Presence and Extent of Disability in the USA, 2019–2020
Authors: Newby‐Kew Abigail , Snowden Jonathan M. , Valentine Anne , Akobirshoev Ilhom , Mitra Monika , Horner‐Johnson Willi 
Published: January 2025

ABSTRACTContextOver 40% of pregnancies in the United States are unintended. Women with unintended pregnancies may be less likely to receive timely prenatal care and engage in healthy behaviors immediately before and during pregnancy. Limited research suggests that women with disabilities are more likely to have an unintended pregnancy, but to date no studies have assessed whether intendedness varies by extent of disability.MethodsWe analyzed 2019–2020 PRAMS data from 22 sites that included the Washington Group Short Set of Questions on Disability (n = 37,832). We examined associations of extent of disability (none, some difficulty, or a lot of difficulty) with pregnancy intendedness (classified as intended, mistimed, unwanted, or unsure). We used multinomial logistic regression to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) while controlling for sociodemographic characteristics.ResultsOverall, 60.1% of pregnancies were intended, 18.2% mistimed, 6.4% unwanted, and 15.3% unsure. Compared to respondents with no difficulty, respondents with some difficulty or a lot of difficulty were more likely to report a mistimed pregnancy (aOR = 1.55, 95%CI 1.40,1.71; aOR = 1.62, 95%CI 1.34,1.95), an unwanted pregnancy (aOR = 1.92, 95%CI 1.66,2.24; aOR = 2.20; 95%CI 1.72,2.82), and unsure intendedness (aOR = 1.61, 95%CI 1.45,1.79; aOR = 1.75, 95%CI 1.45,2.11), respectively.ConclusionsPeople with disabilities who give birth, regardless of extent of disability, had elevated odds of mistimed and unwanted pregnancy and of being unsure of their pregnancy intendedness. Our findings support the use of more inclusive measures of disability and emphasize the need for equitable reproductive healthcare that respects the childbearing potential and choices of individuals with disabilities.
Mineralization Characteristics of the Hokuryu Epithermal Au‐Ag Deposit, Hokkaido, Japan
Authors: Soberano Omar Baculna , Takahashi Ryohei , Manalo Pearlyn , Agangi Andrea , Sato Hinako , Nopeia Manuel 
Published: January 2025

ABSTRACTVeins intersected by a ~600‐m‐long drill core into the Hokuryu epithermal Au‐Ag deposit in the northeastern part of Hokkaido, Japan, were investigated including mineralogy, texture, quartz composition, and fluid inclusion characteristics, with relation to elevation. Host rocks of these veins are flow‐banded rhyolite, pyroclastic breccia, and andesite and are mainly altered by illite and chlorite. The veins display crustiform and massive macroscopic textures. The crustiform veins generally located at higher elevations, contain Ag‐rich and Au‐Ag‐rich bands. The massive veins are mainly present at lower elevations, and they are generally barren of precious metals. The Ag‐rich bands in the crustiform veins contain mineral assemblage of hessite + sphalerite + pyrite + galena. These minerals, together with anhedral to rhombic adularia, exist within the interstices of quartz that display microspherical texture. The Au‐Ag‐rich bands contain mineral assemblage of electrum ± naumannite‐aguilarite associated with quartz with colloform, ghost‐sphere, and ghost‐bladed textures. Bulk compositions of the veins reflect the ore mineralogy observed in which Ag is strongly correlated with Pb, Te, Zn, Cd, and Bi. The barren massive veins are mainly composed of granular quartz. Textural and mineralogical characteristics of Au‐ and Ag‐bearing bands in the crustiform veins indicate amorphous silica and calcite precursors. Together with the coexistence of adularia, these suggest liquid boiling during vein formation. Quartz associated with Au‐ and Ag‐bearing minerals exhibits blue cathodoluminescence (ca. 400 nm wavelength) triggered by high Al impurity probably due to pH and pressure fluctuations or impurity redistribution during recrystallization from metastable amorphous silica. Fluid inclusions hosted in quartz and adularia, which contain negligible amounts of CO2, show a modal homogenization temperature range of 260°C–290°C and a salinity range of 1.2–6.9 wt% NaCl equivalent. The homogenization temperatures follow a boiling point curve and indicate an erosion of up to ~340 m for the deposit. The variable salinities in relation to elevation suggest extreme vapor loss during boiling at depth, episodic influx of high salinity fluids from deeper source, or mixing with high salinity fluids along anastomosing fractures at relatively shallower depths.
Documenting a coastal sediment routing tract in the sedimentary record: Implications for coastal palaeogeography and sand distribution patterns
Authors: Isla Manuel , Schwarz Ernesto , Caracciolo Luca , Remírez Mariano Nicolas , Veiga Gonzalo D. , Finzel Emily 
Published: January 2025

ABSTRACTCoastal sediment transport, primarily driven by littoral drift, is a well‐understood process occurring in many wave‐dominated modern coasts. This transport can extend over hundreds of kilometres, linking river mouths to sand barriers and coastal dunes. Recognizing the importance of coast‐parallel processes in dispersing significant sediment volumes, both source‐to‐sink and sediment‐routing‐system concepts emphasize the need to include these processes in comprehensive studies. These processes can lead to volume changes and provenance mixing within specific source‐to‐sink budgets and should consider sediments near the coast and on the shelf as temporary repositories before their final transit into deep‐water sinks. Despite the established methodologies for studying sediment routing systems, the integration of these approaches with the geological record is limited. To address this gap, this article introduces the Coastal Sediment Routing Tract as a segment within any Sediment Routing System. The Coastal Sediment Routing Tract consists of three elements: supplier(s), storage(s) and littoral drift processes. This study presents the conceptual framework for Coastal Sediment Routing Tracts, documents an ancient Coastal Sediment Routing Tract by linking deltaic and shoreface sandstones in the Hauterivian Pilmatué Member (Neuquén Basin, Argentina) and evaluates how characterizing a single Coastal Sediment Routing Tract can refine coastal palaeogeographical reconstructions. Understanding these aspects is crucial for improving mass balance calculations in source‐to‐sink analyses of ancient systems.
Accessibility, Car Dependence and Rural Peripheralization: The Automobility Gap in the Spanish Countryside
Authors: Oliva Jesus , Camarero Luís 
Published: January 2025

ABSTRACTDisparities in access to opportunities and services often accumulate in peripheral rural areas, contributing to a sense of being left out of prosperity. To bridge this gap, regular commuting to cities where jobs and resources are concentrated has partly replaced emigration, making the private car the key to settling and living in the countryside. However, car dependency reveals important fractures within the rural population. Our work examines the relationship between mobility capabilities and life opportunities by analysing the Spanish case. The results underscore the link between automobility deficits and the risk of exclusion. In a context where rural depopulation and gentrification, hypermobility and mobility deprivation coexist, car dependency needs to be addressed beyond a transport problem as a variable of social peripheralization. The conclusions highlight the need for rural policies to address the challenges posed by this issue in the current transitions to greener mobility paradigms and ageing societies.