bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boron‐Dipyrromethene‐Based Fluorescent Emitters Enable High‐Performance Narrowband Red Organic Light‐Emitting Diodes
Authors: Liu Jiahui , Liu Junjie , Li Haoyuan , Bin Zhengyang , You Jingsong 
Published: June 2023

AbstractNarrowband organic light‐emitting diodes (OLEDs) are receiving significant attention and have demonstrated impressive performance in blue and green OLEDs. However, developing high‐performance narrowband red OLEDs remains a highly desired yet challenging task. Herein, we have developed narrowband red fluorescent emitters by utilizing a boron‐dipyrromethene (BODIPY) skeleton in combination with a methyl‐shield strategy. These emitters exhibit small full‐width at half‐maxima (FWHM) ranging from 21 nm (0.068 eV) to 25 nm (0.081 eV) and high photoluminescence quantum yields (ΦPL) ranging from 88.5 % to 99.0 % in toluene solution. Using BODIPY‐based luminescent materials as emitters, high‐performance narrowband red OLEDs have been assembled with external quantum efficiency as high as 18.3 % at 623 nm and 21.1 % at 604 nm. This work represents, to our knowledge, the first successful case of achieving NTSC pure‐red OLEDs with the Commission Internationale de l’Éclairage (CIE) coordinates of [0.67, 0.33] based on conventional fluorescent emitters.
Statistics and probability theory in renewable energy: Teaching and research
Authors: Eryilmaz Serkan , Kateri Maria , Devrim Yilser 
Published: June 2023

AbstractIn this paper, the key‐role and utility of statistics and probability theory in the field of renewable energy are emphasized and illustrated via specific examples. It is demonstrated that renewable energy is a very suitable field to effectively teach and implement many statistical and probabilistic concepts and techniques. From a research point of view, statistical and probabilistic methods have been successfully employed in evaluating renewable energy systems. These methods will continue to be of core interest for the renewable energy sector in the future, as new and more complex renewable energy systems are developed and installed. In this context, some future research directions in relation to the evaluation of renewable energy systems are also presented.
Viral clearance in end‐to‐end integrated continuous process for mAb purification: Total flow‐through integrated polishing on two columns connected to virus filtration
Authors: Shirataki Hironobu , Matsumoto Yoshihiro , Konoike Fuminori , Yamamoto Shuichi 
Published: June 2023

AbstractThere are few reports of the adoption of continuous processes in bioproduction, particularly the implementation of end‐to‐end continuous or integrated processes, due to difficulties such as feed adjustment and incorporating virus filtration. Here, we propose an end‐to‐end integrated continuous process for a monoclonal antibody (mAb) with three integrated process segments: upstream production processes with pool‐less direct connection, pooled low pH virus inactivation with pH control and a total flow‐through integrated polishing process in which two columns were directly connected with a virus filter. The pooled virus inactivation step defines the batch, and high impurities reduction and mAb recovery were achieved for batches conducted in succession. Viral clearance tests also confirmed robust virus reduction for the flow‐through two‐column chromatography and the virus filtration steps. Additionally, viral clearance tests with two different hollow fiber virus filters operated at flux ranging from 1.5 to 40 LMH (liters per effective surface area of filter in square meters per hour) confirmed robust virus reduction over these ranges. Complete clearance with virus logarithmic reduction value ≥4 was achieved even with a process pause at the lowest flux. The end‐to‐end integrated continuous process proposed in this study is amenable to production processes, and the investigated virus filters have excellent applicability to continuous processes conducted at constant flux.
Characterization of white matter alterations using diffusion kurtosis imaging in patients with amyotrophic lateral sclerosis
Authors: Anand Tanushka , Ishaque Abdullah , Ta Daniel , Khan Muhammad Umer , Bharti Komal , Wu Andrew , Krebs Dennell , Beaulieu Christian , Seres Peter , Kalra Sanjay 
Published: June 2023

AbstractBackgroundTo evaluate the degeneration of the corticospinal tract (CST) and corpus callosum (CC) in patients with motor neuron disease and upper motor neuron (UMN) dysfunction using diffusion kurtosis imaging (DKI).MethodsTwenty‐seven patients and 33 healthy controls underwent magnetic resonance imaging along with clinical and neuropsychological testing. Tractography of diffusion tensor images was performed to extract tracts of the bilateral CST and CC. Group mean differences both across the entire averaged tract and along each tract were assessed, including correlations between diffusion metrics and clinical measures. Tract‐based spatial statistics (TBSS) was performed to evaluate the spatial distribution of whole‐brain microstructural abnormalities in patients.ResultsIn comparison to controls, patients had significantly higher mean and radial diffusivity and lower fractional anisotropy (FA), kurtosis anisotropy, mean kurtosis (MK), and radial kurtosis (RK) in the CST and CC (p < .017). Along‐the‐tract analysis revealed changes concentrated in the posterior limb of the internal capsule, corona radiata, and primary motor cortex (false‐discovery rate p < .05). FA of the left CST correlated with disease progression rate, whereas MK of the bilateral CST correlated with UMN burden (p < .01). TBSS results corroborated along‐tract analysis findings and additionally revealed reduced RK and MK in the fornix, where diffusion tensor imaging (DTI) changes were absent.ConclusionDKI abnormalities in the CST and CC are present in patients with UMN dysfunction, potentially revealing complementary information to DTI regarding the pathology and microstructural alterations occurring in such patients. DKI shows promise as a potential in vivo biomarker for cerebral degeneration in amyotrophic lateral sclerosis.
Estonian National Mental Health Study: Design and methods for a registry‐linked longitudinal survey
Authors: Laidra Kaia , Reile Rainer , Havik Merle , Leinsalu Mall , Murd Carolina , Tulviste Jaan , Tamson Merili , Akkermann Kirsti , Kreegipuu Kairi , Sultson Hedvig , Ainsaar Mare , Uusberg Andero , Rahno Jaana , Panov Liisi , Leetmaa Kadri , Aasa Anto , Veidebaum Toomas , Lehto Kelli , Konstabel Kenn 
Published: June 2023

AbstractObjectivesThe Estonian National Mental Health Study (EMHS) was conducted in 2021–2022 to provide population‐wide data on mental health in the context of COVID‐19 pandemic. The main objective of this paper is to describe the rationale, design, and methods of the EMHS and to evaluate the survey response.MethodsRegionally representative stratified random sample of 20,000 persons aged 15 years and older was drawn from the Estonian Population Register for the study. Persons aged 18 years and older at the time of the sampling were enrolled into three survey waves where they were invited to complete an online or postal questionnaire about mental well‐being and disorders, and behavioral, cognitive, and other risk factors. Persons younger than 18 years of age were invited to fill an anonymous online questionnaire starting from wave 2. To complement and validate survey data, data on socio‐demographic, health‐related, and environmental variables were collected from six national administrative databases and registries. Additionally, a subsample was enrolled into a validation study using ecological momentary assessment.ResultsIn total, 5636 adults participated in the survey wave 1, 3751 in wave 2, and 4744 in wave 3. Adjusted response rates were 30.6%, 21.1%, and 27.6%, respectively. Women and older age groups were more likely to respond. Throughout the three survey waves, a considerable share of adult respondents screened positive for depression (27.6%, 25.1%, and 25.6% in waves 1, 2, and 3, respectively). Women and young adults aged 18 to 29 years had the highest prevalence of depression symptoms.ConclusionsThe registry‐linked longitudinal EMHS dataset comprises a rich and trustworthy data source to allow in‐depth analysis of mental health outcomes and their correlates among the Estonian population. The study serves as an evidence base for planning mental health policies and prevention measures for possible future crises.
The arcuate fasciculus: Combining structure and function into surgical considerations
Authors: Vavassori Laura , Venturini Martina , Zigiotto Luca , Annicchiarico Luciano , Corsini Francesco , Avesani Paolo , Petit Laurent , De Benedictis Alessandro , Sarubbo Silvio 
Published: June 2023

AbstractBackgroundTwo Centuries from today, Karl Friedrich Burdach attributed the nomenclature “arcuate fasciculus” to a white matter (WM) pathway connecting the frontal to the temporal cortices by arching around the Sylvian fissure. Although this label remained essentially unvaried, the concepts related to it and the characterization of the structural properties of this bundle evolved along with the methodological progress of the past years. Concurrently, the functional relevance of the arcuate fasciculus (AF) classically restricted to the linguistic domain has extended to further cognitive abilities. These features make it a relevant structure to consider in a large variety of neurosurgical procedures.ObjectiveHerein, we build on our previous review uncovering the connectivity provided by the Superior Longitudinal System, including the AF, and provide a handy representation of the structural organization of the AF by considering the frequency of defined reports in the literature. By adopting the same approach, we implement an account of which functions are mediated by this WM bundle. We highlight how this information can be transferred to the neurosurgical field by presenting four surgical cases of glioma resection requiring the evaluation of the relationship between the AF and the nearby structures, and the safest approaches to adopt.ConclusionsOur cumulative overview reports the most common wiring patterns and functional implications to be expected when approaching the study of the AF, while still considering seldom descriptions as an account of interindividual variability. Given its extension and the variety of cortical territories it reaches, the AF is a pivotal structure for different cognitive functions, and thorough understanding of its structural wiring and the functions it mediates is necessary for preserving the patient's cognitive abilities during glioma resection.
Mentalization Scale (MentS): Validity and reliability of the Iranian version in a sample of nonclinical adults
Authors: Asgarizadeh Ahmad , Vahidi Elahe , Seyed Mousavi Parisa Sadat , Bagherzanjani Ali , Ghanbari Saeed 
Published: June 2023

AbstractIntroductionMentalizing incapacity is increasingly identified as a common factor in psychopathology. The Mentalization Scale (MentS) is a cost‐effective measure built upon the dimensional model of mentalizing. We aimed to evaluate the psychometric properties of the Iranian version of MentS.MethodsTwo samples of community‐based adults (N1 = 450, N2 = 445) completed different batteries of self‐report measures. In addition to MentS, participants completed measures of reflective functioning and attachment insecurities in the first sample and a measure of emotion dysregulation in the second sample.ResultsDue to the conflicting results of confirmatory and exploratory factor analyses, an item‐parceling approach was applied, which replicated the original three‐factor structure of MentS, yielding Self‐Related Mentalization, Other‐Related Mentalization, and Motivation to Mentalize. The reliability and convergent validity of MentS were supported in both samples.ConclusionOur findings provided preliminary evidence for using the Iranian version of MentS in nonclinical populations as a reliable and valid measure.
Causal relationship between gastroesophageal reflux disease, Barrett's esophagus, and epilepsy: A bidirectional Mendelian randomization study
Authors: Liu Xiaoduo , Wei Tao , Shi Lubo , Zhou Shaojiong , Liu Yufei , Song Weiyi , Que Xinwei , Wang Zhibin , Tang Yi 
Published: June 2023

AbstractBackgroundThe incidence of gastroesophageal reflux disease (GERD) has been shown to be elevated in individuals with epilepsy. Traditional observational studies have led to a limited understanding of the effects of GERD and BE on epilepsy due to the interference of reverse causation and potential confounders.MethodsWe conducted a bidirectional two‐sample Mendelian randomization (MR) analysis to determine whether GERD and BE can increase the risk of epilepsy. Genome‐wide association study data on epilepsy and its subgroups were obtained from the International League Against Epilepsy consortium for primary analysis using three MR approaches and the FinnGen consortium for replication and meta‑analysis. We calculated causal estimates between the two esophageal diseases and epilepsy using the inverse‐variance weighted method. Sensitivity analysis was conducted to detect heterogeneity and pleiotropy.ResultsWe found a potential effect of genetically predicted GERD on the risk of epilepsy (odds ratio [OR] = 1.078; 95% confidence interval [CI], 1.014–1.146, p = .016). Specifically, GERD showed an effect on the risk of generalized epilepsy (OR = 1.163; 95% CI, 1.048–1.290, p = .004) but not focal epilepsy (OR = 1.059, 95% CI, 0.992–1.131, p = .084). Notably, BE did not show a significant causal relationship with the risks of generalized and focal epilepsy.ConclusionsUnder MR assumptions, our findings suggest a potential risk‐increasing effect of GERD on epilepsy, especially generalized epilepsy. Considering the exploratory nature of our study, the association between GERD and epilepsy needs to be confirmed by future prospective studies.
Proteomic analysis identifies HMGA2 as a novel biomarker of overall survival in papillary renal cell carcinoma
Authors: Wei Tian , Xu Huiya , Liang Huishan , Lian Yating , Chen Huiyu , Zheng Zhangyi , Zhong Minghui , Liu Junfeng , Wang Ran , Wang Fen 
Published: June 2023

AbstractPurposeAlthough papillary renal cell carcinoma (PRCC) has a relatively favorable prognosis, a small number of patients with lymph node or distant metastasis have a poor prognosis. Owing to the complex typing and heterogeneity of PRCC, it remains difficult to provide risk stratification. The objective of our research was to identify potential markers of PRCC prognosis.MethodsWe performed proteomics and bioinformatics analyses on six pairs of formalin‐fixed paraffin‐embedded tumor and paired normal tissue samples. The Cancer Genome Atlas (TCGA) data were used to analyze the prognostic value of differentially expressed proteins (DEPs) in PRCC. We verified the expression of the major biomarker through immunohistochemistry (IHC) in 91 PRCC tumor specimens.ResultsProteomic analysis revealed 1544 DEPs between tumor and paired normal tissues. PRCC transcriptomic data from the TCGA database revealed that compared to non‐tumor tissues, the expression of high‐mobility group protein A2 (HMGA2) was upregulated in tumor tissues, and patients with high HMGA2 expression exhibited shorter overall survival times. HMGA2 was associated with PRCC tissue subtype and higher cell pleomorphism. Both TCGA and IHC results showed that HMGA2 expression was associated with lymph node metastasis and clinical stage.ConclusionHMGA2 was positively correlated with malignant progression and could be a valuable novel prognostic biomarker for PRCC risk stratification.
The role of nanoliposomal irinotecan plus fluorouracil/leucovorin in the continuum of care of patients with metastatic pancreatic ductal adenocarcinoma
Authors: Procaccio Letizia , Merz Valeria , Fasano Morena , Vaccaro Vanja , Giommoni Elisa , Pretta Andrea , Noventa Silvia , Satolli Maria Antonietta , Giordano Guido , Zichi Clizia , Pinto Carmine , Zecchetto Camilla , Barsotti Giulia , De Vita Ferdinando , Milella Michele , Antonuzzo Lorenzo , Scartozzi Mario , Zaniboni Alberto , Spadi Rosella , Casalino Simona , Bergamo Francesca , De Toni Chiara , Melisi Davide , Lonardi Sara 
Published: June 2023

AbstractBackgroundThe NAPOLI‐I trial showed better outcome of nanoliposomal irinotecan (nal‐IRI) plus 5‐fluorouracil/leucovorin (5‐FU/LV) compared to 5‐FU/LV in patients with advanced pancreatic ductal adenocarcinoma cancer (advPDAC) progressed to gemcitabine‐based therapy. This study aims to explore the real‐world efficacy and safety of 5‐FU/LV‐nal‐IRI.MethodsThis is a retrospective multicenter analysis including advPDAC patients receiving 5‐FU/LV‐nal‐IRI after failure of gemcitabine‐based therapy. Survival analyses were performed using Kaplan–Meier method, univariate and multivariate analyses by Cox regression.ResultsA total of 296 patients (median age 64.4 years, ECOG PS ≥1 in 56% of cases) were treated at 11 Italian institutions between 2016 and 2018. 34% of them underwent primary tumor resection, and 79% received gemcitabine‐nabpaclitaxel as first line. 5‐FU/LV‐nal‐IRI was administered as second‐line in 73% of cases.Objective response and disease control rate were 12% and 41%, respectively. Treatment was well tolerated with dose reductions in 50% of patients but no one permanent discontinuation; the commonest grade ≥3 toxicities were neutropenia (14%) and diarrhea (12%). Median PFS and OS from 5‐FU/LV‐nal‐IRI initiation was 3.2 and 7.1 months, respectively.ConclusionsThese real‐world data confirm the 5‐FU/LV‐nal‐IRI efficacy and safety in advPDAC patients progressed to gemcitabine‐based therapy, with outcomes comparable to NAPOLI‐1, even in a less‐selected population and with more modern therapeutic algorithm.
Financial well‐being as a mediator of the relationship between multimorbidity and health‐related quality of life in people with cancer
Authors: So Winnie K. W. , Au Doreen W. H. , Chan Dorothy N. S. , Ng Marques S. N. , Choi Kai Chow , Xing Weijie , Chan Mandy , Mak Suzanne S. S. , Ho Pui Shan , Tong Man , Au Cecilia , Ling Wai Man , Chan Maggie , Chan Raymond J. 
Published: June 2023

AbstractBackgroundIt is unknown whether financial well‐being mediates the impact of multimorbidity on the health‐related quality of life (HRQoL) of cancer patients.MethodsParticipants were recruited from three outpatient oncology clinics of Hong Kong public hospitals. Multimorbidity was assessed using the Charlson Comorbidity Index. Financial well‐being, the mediator of the association between multimorbidity and HRQoL outcomes, was assessed using the Comprehensive Score for Financial Toxicity Functional Assessment of Chronic Illness Therapy. The HRQoL outcomes were assessed using the Functional Assessment of Cancer Therapy – General (FACT‐G) and its four sub‐dimensions. Mediation analyses were conducted using SPSS PROCESS v4.1.ResultsSix‐hundred and forty cancer patients participated in the study. Multimorbidity had a direct effect on FACT‐G scores independent of financial well‐being (β for path c’ = −0.752, p < 0.001). In addition, multimorbidity had an indirect effect on FACT‐G scores through its effect on financial well‐being (β for path a = −0.517, p < 0.05; β for path b = 0.785, p < 0.001). Even after adjustments were made for the covariates, the indirect effect of multimorbidity on FACT‐G via financial well‐being remained significant, accounting for 38.0% of the overall effect, indicating partial mediation. Although there were no statistically significant associations between multimorbidity, social well‐being, and emotional well‐being, the indirect effects of multimorbidity on physical and functional well‐being through financial well‐being remained significant.ConclusionsPoor financial well‐being attributable to multimorbidity partially mediates the direct impact of chronic conditions on HRQoL in Chinese cancer patients, particularly their physical and functional well‐being.
Mapping and analysis of volatomes from pearl millet (Pennisetum gaucum L.) grains during different storage conditions with solid‐phase microextraction–gas chromatography–mass spectrometry
Authors: Selvan Shilpa S. , Mohapatra Debabandya , Kate Adinath , Kar Abhijit , Modhera Bharat 
Published: June 2023

AbstractBackground and ObjectivesVolatile organic compounds (VOCs) are considered biomarkers for the metabolic activities of biological entities. This work analyzed the impact of storage period and temperature (5°C, 25°C, and 45°C) on the VOC profile of pearl millet grains stored for 120 days through headspace gas analysis using solid‐phase microextraction–gas chromatography–mass spectroscopy (SPME‐GC‐MS).FindingsThe major groups identified in the pearl millet grains belonged to acid, alcohol, aldehyde, alkane, and ester groups. VOC data were analyzed using principal component analysis, partial least square discriminant analysis (PLS‐DA), cluster heat map, and network analysis of metabolite–metabolite interactions. The PLS‐DA could distinctly classify the VOCs generated with respect to different storage conditions. The VOCs generated during storage indicated the four most significant metabolic pathways, that is, fatty acid biosynthesis, cutin, suberine and wax biosynthesis, arginine biosynthesis, and arginine and proline metabolism.ConclusionsThe SPME‐GC‐MS protocol developed for mapping VOC through this study and the classification protocol developed can be used for developing quality monitoring systems in pearl millet grains.Significance and NoveltyIdentification of VOCs at a particular period will be helpful for the recommendation of appropriate remedial measures at the right time to avoid the spoilage of grains.
Severe laryngeal edema after CAR‐T cell treatment in a patient with multiple myeloma: A case report
Authors: Alvarez de Linera Alperi Marta , Ferran de la Cierva Sol , Palacios Berraquero Maria , Terrasa Czapiewska David , Alfonso Ana , Fernandez Gonzalez Secundino 
Published: June 2023

Key Clinical MessageThis case aims to report an unusual clinical situation with uncommon and severe side effects, which can even be life threatening for the patient. The ENT and Hematology specialist should be aware of diagnosing and treating adequately.
Rumpel‐Leede phenomenon as a rare complication after transulnar percutaneous coronary angiography and intervention
Authors: Sandoval Letícia , Cafundó Nayara Rodrigues , Ferreira Raphael , Segovia Samela , Rosa Ximena 
Published: June 2023

AbstractThe Rumpel‐Leede sign, characterized by a non‐blanching petechial rash distal to venous occlusion, has historically been associated with thrombocytopenia and capillary fragility. This phenomenon has been observed in various situations involving pressure application, such as tourniquet tests and continuous non‐invasive pressure monitoring. Here, we present a case of Rumpel‐Leede sign occurring after transulnar percutaneous coronary angiography in a 55‐year‐old female patient with a history of myocardial infarction. The patient had an uneventful recovery, highlighting the benign nature of the rash and the lack of intervention required. This underscores the importance of recognizing this sign and its association with specific procedures.
Metastatic renal cell carcinoma presenting as multiple cutaneous lesions visualized through reflectance confocal microscopy
Authors: Razi Shazli , Ouellette Samantha , Khan Samavia , Rao Babar 
Published: June 2023

Key Clinical MessageWe present the first case of metastatic renal cell carcinoma visualized via reflectance confocal microscopy (RCM). This case describes the RCM features of such a tumor, in an effort to improve noninvasive characterization of cutaneous metastases.
Cardiac calcified amorphous tumor in a patient with colon cancer
Authors: Alizadehasl Azin , Iranian Mohammadreza , Rezaei‐Kalantari Kiara , Sepehr Farzaneh , Mohebi Somaye , Mohammadi Mahsa 
Published: June 2023

Key Clinical MessageAlthough one of the most important differential diagnoses of cardiac masses in cancer patients is metastasis from the underlying tumor, it may also be caused by benign etiologies. In this article, we describe cardiac calcified amorphous tumor, which is one of the benign causes of cardiac masses, in a patient with colon cancer.