bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic profiling of dedifferentiated endometrial carcinomas arising in the background of high‐grade carcinoma: a targeted next‐generation sequencing study
Authors: Olkhov‐Mitsel Ekaterina , Busca Aurelia , Parra‐Herran Carlos , Amemiya Yutaka , Nofech‐Mozes Sharon , Djordjevic Bojana , Nucci Marisa R , Seth Arun , Mirkovic Jelena 
Published: May 2023

AimsOur understanding of dedifferentiated endometrial carcinoma (DEC), a rare and aggressive malignancy, mainly reflects undifferentiated carcinomas (UC) arising in the setting of low‐grade endometrial cancer (DEC‐LG). However, cases of UC arising in the setting of high‐grade EC (DEC‐HG) have been noted in the literature. Our knowledge of the genomics of DEC‐HG is limited. To characterise the molecular landscape of DEC‐HC, targeted genomic sequencing and immunohistochemical analysis was carried out on seven DEC‐HG and four DEC‐LG.Methods and resultsDEC‐HG and DEC‐LG, including undifferentiated and differentiated components, both showed a similar frequency and spectrum of mutations. ARID1A mutations were identified in 6/7 (86%) DEC‐HG and 4/4 (100%) DEC‐LG, while SMARCA4 mutations were present in 4/7 (57%) DEC‐HG and in 1/4 (25%) DEC‐LG. Concurrent SMARCA4/BRG1 protein loss by immunohistochemistry was observed in 3/4 and 1/1 SMARCA4 mutated DEC‐HG and DEC‐LG, respectively. Neither genomic alterations nor protein loss in SMARCB1/INI1 were observed in any of our cases. TP53 mutations were detected in 4/7 (57%) DEC‐HG and in 2/4 (50%) DEC‐LG, while mutation‐pattern p53 immunohistochemistry expression was observed in 2/7 (29%) DEC‐HG and none of the DEC‐LG. MLH1 mutations were observed in 1/7 (14%) DEC‐HG and 1/4 (25%) DEC‐LG. MSH2 and MSH6 mutations were each detected in 1/7 (14%) DEC‐HG, but neither was associated with corresponding loss of protein expression.ConclusionThe findings support expanding the definition of DEC to include DEC‐HG, a previously under‐recognised phenomenon with genomic similarities to DEC‐LG.
Characteristics and prognostic significance of polo‐like kinase‐1 (PLK1) expression in breast cancer
Authors: Lashen Ayat G , Toss Michael S , Wootton Louisa , Green Andrew R. , Mongan Nigel P , Madhusudan Srinivasan , Rakha Emad 
Published: May 2023

AimPolo‐like kinase‐1 (PLK1) plays a crucial role in cell cycle progression, and it is considered a potential therapeutic target in many cancers. Although the role of PLK1 is well established in triple‐negative breast cancer (TNBC) as an oncogene, its role in luminal BC is still controversial. In this study, we aimed to evaluate the prognostic and predictive role of PLK1 in BC and its molecular subtypes.MethodsA large BC cohort (n = 1208) were immunohistochemically stained for PLK1. The association with clinicopathological, molecular subtypes, and survival data was analysed. PLK1 mRNA was evaluated in the publicly available datasets (n = 6774), including The Cancer Genome Atlas and the Kaplan–Meier Plotter tool.Results20% of the study cohort showed high cytoplasmic PLK1 expression. High PLK1 expression was significantly associated with a better outcome in the whole cohort, luminal BC. In contrast, high PLK1 expression was associated with a poor outcome in TNBC. Multivariate analyses indicated that high PLK1 expression is independently associated with longer survival in luminal BC, and in poorer prognosis in TNBC. At the mRNA levels, PLK1 expression was associated with short survival in TNBC consistent with the protein expression. However, in luminal BC, its prognostic value significantly varies between cohorts.ConclusionThe prognostic role of PLK1 in BC is molecular subtype‐dependent. As PLK1 inhibitors are introduced to clinical trials for several cancer types, our study supports evaluation of the pharmacological inhibition of PLK1 as an attractive therapeutic target in TNBC. However, in luminal BC, PLK1 prognostic role remains controversial.
WHAT, AT LONG LAST, IS HISTORICAL THEORY FOR? REFLECTIONS ON HISTORICAL THEORY IN A POST‐TRUTH WORLD
Authors: PARTNER NANCY 
Published: May 2023

ABSTRACTThe term “post‐truth” is a capacious trope that collects threats to the stability of shared knowledge on many fronts—digitally spread disinformation, ignorance and resistance to science, unabashed lies in the public sphere, mythologizing by resurgent nationalist forces, and so on. History is particularly vulnerable to this array. Post‐truth threats to serious history produced to professional standards for research and reasoning by historians free of coercion, intimidation, or pressures for co‐optation are too blatant to need explanation. Avenues of response to the politicizing of history have been protests by public intellectuals and academics and a growing scholarly literature recording the imposition of memory laws by the police powers of numerous states. Attacks on empirical history, and the academic freedom required to sustain it, provoke clear responses, but the situation of historical theory is more problematic. Historical theory is a superstructure of analysis that presupposes the free production of history that invites and justifies the cultural work of theorizing. Reading Karen S. Feldman's Arts of Connection: Poetry, History, Epochality, an erudite, philosophical contribution to historical theory advancing a severe critique of history's fundamental powers of representation against a widening background of nationalist state‐sponsored policing of history, produced an acute cognitive dissonance in this reviewer. In this essay, I frankly acknowledge this dissonant experience and lay out some of the most egregious causes of it in history distorted and undermined to nationalist ends in Russia, Poland, Hungary, and beyond. I pose the question of whether the intellectual work of theorizing history can continue with any confidence when the ground on which theory stands is being eroded and distorted.
Customer experience in social commerce: A systematic literature review and research agenda
Authors: Dhaigude Soma Amol , Mohan Bijuna C. 
Published: May 2023

AbstractSocial commerce (SC) is an upcoming trend that has changed the online shopping experience by allowing e‐retailers to develop long‐term relationships with customers and increase sales. Empowered by Web 3.0, SC offers many‐to‐many interactions, enhancing the quality and quantity of social interaction related to the seller–customer, information searches, and product/service delivery. The customer experience (CEX) has been well developed both in the online and offline contexts. However, limited attention has been paid to examining CEX in the SC setting. This study aims to conduct a systematic review of the literature to develop a conceptual framework exploring both the antecedents and consequences of CEX in the SC setting. In the process, we make three significant contributions to academia and practice. First, the study contributes to our understanding of CEX in the context of SC. Second, it proposes a conceptual framework by identifying antecedents of CEX and potential consequences using the consumer culture theory. Finally, it highlights a subject relevant to academia and practice while proposing recommendations for further research.
Targeting the BRAF pathway in haematological diseases
Authors: Rees Matthew J. , Dickinson Michael , Paterson James , Ng Teng F. , Grigg Andrew , Moore John , Blombery Piers , Seymour John F. 
Published: May 2023

AbstractSince the recognition of BRAF V600E mutations in the majority of cases of hairy cell leukaemia, Erdheim–Chester disease and Langerhans cell histiocytosis, the targeted oral kinase inhibitors dabrafenib and vemurafenib have been adapted for their treatment. Like other targeted agents, these drugs produce high response rates and predictable but unique side effects. Physician familiarity is essential for the effective use of these agents. We review the Australian experience of BRAF/MEK inhibitor therapy in these rare haematological cancers.
Prevalence of depression symptoms among female adolescents in Saudi Arabia
Authors: Binsaif Samr , Reynolds Shirley , Jenkins Paul 
Published: May 2023

AbstractObjectiveEpidemiological studies on the prevalence of elevated depression symptoms among female adolescents in Saudi Arabia report a wide variation, ranging from 13.9% to 80.2%. However, different methods of assessment and sampling have been used. The aim of the current study is to estimate the prevalence of elevated depression symptoms amongst female adolescents in Saudi Arabia using a gold‐standard self‐report measure, the Mood and Feelings Questionnaire (MFQ).Design and MeasuresA cross‐sectional study was conducted with 515 female students aged 13−18 years, recruited from public schools. Participants completed the Arabic versions of the MFQ, Rosenberg Self‐Esteem Scale and Multidimensional Scale of Perceived Social Support.ResultsMean MFQ score for this sample was 26.35 and almost half of participants (48.2%) had scores above the cut‐off. Severity of depression varied with age, with those aged 13 showing reduced symptoms, and was negatively correlated with self‐esteem and perceived social support. There were no associations with other demographic factors.ConclusionElevated levels of depression symptoms were common in this sample. This highlights the need to improve public mental health in this community and to improve methods of identifying and treating depression in female adolescents.
Very late‐onset atrial lead perforation leading to pneumopericardium
Authors: Enokizono Kei , Kamakura Tsukasa , Kotoku Akiyuki , Nakata Jun , Matama Hideo , Kusano Kengo 
Published: May 2023

AbstractBackgroundAtrial lead perforation may lead to pneumopericardium or pneumothorax within a few days of device implantation.Methods and ResultsWe report a case of atrial lead perforation 6 years after cardiac resynchronization therapy implantation, which resulted in pneumopericardium and pneumothorax.ConclusionAlthough pneumopericardium caused by atrial lead perforation can spontaneously resolve with conservative treatment, as it did in this case, treatment should be decided based on the patient's general condition and lead performance.
Research Review: The internalizing paradox – youth anxiety and depression symptoms, psychotherapy outcomes, and implications for research and practice
Authors: Weisz John R. , Fitzpatrick Olivia M. , Venturo‐Conerly Katherine E. , Sternberg Ariel , Steinberg Joshua S. , Ng Mei Yi 
Published: May 2023

BackgroundYouth anxiety and depression have long been combined within the empirically derived internalizing syndrome. The two conditions show substantial comorbidity, symptom co‐occurrence, and overlap in treatment procedures, but paradoxically diverge in psychotherapy outcomes: strong, positive effects for anxiety and weak effects for depression.MethodsDrawing on recent research, we examine candidate explanations for this paradox to help identify strategies for addressing it by improving outcomes for youth depression.ResultsCandidate explanations include that youth depression, compared with youth anxiety, has more varied comorbidities and more heterogeneous symptom combinations, has greater uncertainty regarding mediators and mechanisms of change, is treated with more complex and potentially confusing protocols, and has characteristics that may impede client engagement. Candidate strategies for shrinking the psychotherapy effectiveness gap include personalizing through transdiagnostic modular treatment, simplifying therapy by focusing on empirically supported principles of change, developing effective strategies for engaging family members as intervention allies, using shared decision‐making to inform clinical decisions and boost client engagement, capitalizing on youth‐friendly technological advances, and shortening and digitizing treatments to enhance their accessibility and appeal.ConclusionsRecent advances suggest explanations for the internalizing paradox, which in turn suggest strategies for shrinking the youth anxiety–depression psychotherapy outcome gap; these form an agenda for a promising new era of research.
Capital gain overhang and risk–return trade‐off: An international study
Authors: Zheng Dazhi , Li Huimin , Li Fengyun 
Published: May 2023

AbstractIn this article, we examine the risk–return relation under the impact of investors' price reference points in international markets. We calculate capital gain overhang (CGO) to measure the psychological evaluation of past returns. Using a double‐sorting methodology, we find that a negative risk–return trade‐off generally exists in international markets when CGO is low; results using the Fama–MacBeth procedure confirm our findings. The CGO effect is more prominent in less developed, less transparent, and less legally protected markets. It is stronger in markets with collectivistic, higher power‐distanced, and feminine cultures. The evidence also indicates that the price reference effect is more pronounced when the market is in crisis. Finally, the CGO effect on the risk–return relation reverses as the holding period becomes longer.
Sex differences in mortality of older adults with falls after emergency department consultation: FALL‐ER registry
Authors: Miró Òscar , Gil‐Rodrigo Adriana , García‐Martínez Ana , Aguiló Sira , Alemany Xavier , Nickel Christian H. , Jacob Javier , Llorens Pere , Herrero Pablo , Torres‐Machado Victoria , Cenjor Raquel , Coll‐Vinent Blanca , Martínez‐Nadal Gemma , del Nogal Montserrat Lázaro , Peacock Frank , Martín‐Sánchez Francisco Javier 
Published: May 2023

AbstractBackgroundTo investigate if sex is a risk factor for mortality in patients consulting at the emergency department (ED) for an unintentional fall.MethodsThis was a secondary analysis of the FALL‐ER registry, a cohort of patients ≥65 years with an unintentional fall presenting to one of 5 Spanish EDs during 52 predefined days (one per week during one year). We collected 18 independent patient baseline and fall‐related variables. Patients were followed for 6 months and all‐cause mortality recorded. The association between biological sex and mortality was expressed as unadjusted and adjusted hazard ratios (HR) with the 95% confidence interval (95% CI), and subgroup analyses were performed by assessing the interaction of sex with all baseline and fall‐related mortality risk variables.ResultsOf 1315 enrolled patients (median age 81 years), 411 were men (31%) and 904 women (69%). The 6‐month mortality was higher in men (12.4% vs. 5.2%, HR = 2.48, 95% CI = 1.65–3.71), although age was similar between sexes. Men had more comorbidity, previous hospitalizations, loss of consciousness, and an intrinsic cause for falling. Women more frequently lived alone, with self‐reported depression, and the fall results in a fracture and immobilization. Nonetheless, after adjustment for age and these eight divergent variables, older men aged 65 and over still showed a significantly higher mortality (HR = 2.19, 95% CI = 1.39–3.45), with the highest risk observed during the first month after ED presentation (HR = 4.18, 95% CI = 1.31–13.3). We found no interaction between sex and any patient‐related or fall‐related variables with respect to mortality (p > 0.05 in all comparisons).ConclusionsMale sex is a risk factor for death following ED presentation for a fall in the older population adults aged 65 and over. The causes for this risk should be investigated in future studies.
High‐intensity home health physical therapy among older adult Veterans: A randomized controlled trial
Authors: Stevens‐Lapsley Jennifer E. , Derlein Danielle , Churchill Laura , Falvey Jason R. , Nordon‐Craft Amy , Sullivan William J. , Forster Jeri E. , Stutzbach Julie A. , Butera Katie A. , Burke Robert E. , Mangione Kathleen K. 
Published: May 2023

AbstractBackgroundOlder adult Veterans are at high risk for adverse health outcomes following hospitalization. Since physical function is one of the largest potentially modifiable risk factors for adverse health outcomes, our purpose was to determine if progressive, high‐intensity resistance training in home health physical therapy (PT) improves physical function in Veterans more than standardized home health PT and to determine if the high‐intensity program was comparably safe, defined as having a similar number of adverse events.MethodsWe enrolled Veterans and their spouses during an acute hospitalization who were recommended to receive home health care on discharge because of physical deconditioning. We excluded individuals who had contraindications to high‐intensity resistance training. A total of 150 participants were randomized 1:1 to either (1) a progressive, high‐intensity (PHIT) PT intervention or (2) a standardized PT intervention (comparison group). All participants in both groups were assigned to receive 12 visits (3 visits/week over 30 days) in their home. The primary outcome was gait speed at 60 days. Secondary outcomes included adverse events (rehospitalizations, emergency department visits, falls and deaths after 30 and 60‐days), gait speed, Modified Physical Performance Test, Timed Up‐and‐Go, Short Physical Performance Battery, muscle strength, Life‐Space Mobility assessment, Veterans RAND 12‐item Health Survey, Saint Louis University Mental Status exam, and step counts at 30, 60, 90, 180 days post‐randomization.ResultsThere were no differences between groups in gait speed at 60 days, and no significant differences in adverse events between groups at either time point. Similarly, physical performance measures and patient reported outcomes were not different at any time point. Notably, participants in both groups experienced increases in gait speed that met or exceeded established clinically important thresholds.ConclusionsAmong older adult Veterans with hospital‐associated deconditioning and multimorbidity, high‐intensity home health PT was safe and effective in improving physical function, but not found to be more effective than a standardized PT program.
Multigenerational transmission of differentiation of self – Toward a more in‐depth understanding of Bowen's theory concept
Authors: Józefczyk Anna 
Published: May 2023

AbstractThe multigenerational transmission of differentiation of self is one of the basic concepts of Bowen's Family Systems Theory. It describes how the ability to build healthy and intimate relationships with others can be passed down through generations within the family system. Previous research devoted to the concept has yielded mixed results. However, significant discrepancies can be observed between methodological approaches and the resulting understanding of the similarity in self‐differentiation observed between parents and children. The present study examines these inconsistencies and explores the process of transmission on a multifaceted basis. Based on a series of confirmatory factor analyses, our findings lend support to Bowen's theory hypothesis and demonstrate that both parental sex and that of the child play a crucial role in transmission. The article highlights the importance of addressing family issues in promoting satisfying personal and social functioning among young people.
Coparenting change after couple therapy using self‐reports and observational data
Authors: Liekmeier Esther , Vowels Laura M. , Antonietti Jean‐Philippe , Bodenmann Guy , Darwiche Joëlle 
Published: May 2023

AbstractParent couples are involved in a coparenting bond and in a romantic relationship. Research on couple therapy has mainly explored the impact of couple therapy on romantic relationships; however, little is known about how couple therapy affects the coparenting relationship. Self‐reports of positive and negative coparenting and observed emotional behavior in coparenting‐related conversation tasks were assessed pre‐ and posttherapy (6 months intervals) in 64 mixed‐sex parental couples. Results showed that mothers and fathers reported more positive coparenting after therapy. There were no significant changes in the reported negative coparenting and in the emotional behavior. Exploratory analyses indicated gender differences in emotional expression. The findings suggest that fathers might have been more active in the coparenting conversation after therapy.
Associations of circulating metabolites with cerebral white matter hyperintensities
Authors: Sun Yan , Guo Yu , Li Hong‐Qi , Tan Lan , Feng Jian‐Feng , Cheng Wei , Yu Jin‐Tai 
Published: May 2023

AbstractWhite matter hyperintensities (WMH) are the most compelling risk factors of stroke, dementia, and early mortality. We aimed to investigate the associations between WMH and circulating metabolites. We studied up to 8190 individuals from the UK Biobank, who have both measurements of 249 plasma metabolites and WMH volume. Linear regression models were applied in pooled samples, and age‐stratified and sex‐stratified subsamples to estimate the associations between WMH and metabolomic measures. We conducted three analytic models. In the basic model, we identified 45 metabolomic measures associated with WMH after multiple testing correction (p < 0.0022), 15 of which remained significant in additional adjustments, but no metabolites passed the full adjustment in pooled samples. The 15 WMH‐related metabolites were subfractions of various sizes of high‐density lipoprotein (HDL), fatty acids, and glycoprotein acetyls. Among them, one fatty acid metabolite and 12 HDL‐related traits showed significant negative associations with WMH. Higher glycoprotein acetyls were associated with large WMH. Strong age and sex specificities were observed indicating distinct metabolomic features accompany WMH in different samples. More metabolites were identified in males and adults under 50 years old. Circulating metabolites showed remarkably widespread associations with WMH. Population specificities may shed light on the different pertinent implications of WMH.image
Impaired sexual health among women treated for vulvar cancer: An integrated review
Authors: Olesen Mette Linnet , Seibæk Lene , Sekse Ragnhild Johanne Tveit 
Published: May 2023

AbstractBackgroundAlthough gynaecological cancer's negative effects on sexual function are well known, most studies on the subject have not included vulvar cancer patients or a multidimensional perspective on sexual health. Therefore, this review aimed to address this research gap and explored the impact of vulvar cancer on women's sexual health from a multidimensional perspective.MethodologyAn integrated review was conducted, as described by Whittemore and Knafl. The PubMed, CINAHL, PsycINFO and Embase databases were searched in March 2021 and updated in August 2022 and March 2023. The data were thematically analysed using NVivo, and the PRISMA‐ScR and ENTREQ guidelines were followed.FindingsThe following themes were identified in the 28 reviewed articles: impact of a changed female body, impact on women's sexual identity, consequences for women's sexual relationships and unmet needs and loneliness caused by taboos about sexual health.DiscussionWomen's impaired sexual health after vulvar cancer points to a great need to understand and holistically investigate sexual health. In addition, healthcare professionals have an obligation to care for the sexual health issues of patients with vulvar cancer. However, most questionnaires used in the selected studies revealed a narrow understanding of sexual health and focused on sexuality as a genital activity.ConclusionThe sexual health of women with vulvar cancer was tabooed and stigmatised for patients and healthcare professionals. Consequently, women received sparse sexual guidance, felt isolated and had unmet needs.Implications for clinical practiceHealthcare professionals need knowledge and training on how to break taboos and address the sexual needs of vulvar cancer patients. Systematic screenings for sexual health needs should be conducted using a multidimensional perspective.Trial and protocol registrationThe protocol was preregistered at the Open Science Framework (www.osf.io), registration DOI: https://doi.org/10.17605/OSF.IO/YDA2QPatient or public contributionNo patient or public contribution.