bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the results of open PLIF versus UBE PLIF in lumbar spinal stenosis: postoperative adjacent segment instability is lesser in UBE
Authors: Li Xiaobin , Liu Jie , Liu Zhiwei 
Published: July 2023

Abstract
Objective
To compare the difference in efficacy between open PLIF and UBE for lumbar spinal stenosis and the effect on postoperative adjacent segment instability.

Method
The clinical data of 37 patients with PLIF and 32 patients with UBE for lumbar spinal stenosis were retrospectively analyzed to compare the differences in perioperative conditions and short- and medium-term outcomes.

Results
All 69 patients completed the surgery successfully. The operating time, number of intraoperative fluoroscopies and hospital days were higher in the UBE group than in the open PLIF group. Intraoperative bleeding and postoperative drainage were lower than in the open PLIF group (P < 0.05). The visual analogue scale (VAS) of low back pain was lower in the UBE group than in the open PLIF group at 1 month and 3 months postoperatively (P < 0.05), and there were no statistically significant VAS scores for low back pain in the two groups at 1 day and 6 months postoperatively (P > 0.05). Leg pain VAS scores were lower in the UBE group than in the open PLIF group at 1 month, 3 months and 6 months postoperatively (P < 0.05), and leg pain VAS scores were not statistically significant in both groups at 1 day postoperatively (P > 0.05). The ODI index was lower in the UBE group than in the open PLIF group at 1 day and 1 month postoperatively (P < 0.05) and was not statistically significant in the two groups at 3 months and 6 months postoperatively (P > 0.05). There was no statistically significant difference between the two groups in postoperative interbody height, sagittal diameter of the spinal canal, efficacy of modified MacNab and interbody fusion (P > 0.05). The open PLIF group was more prone to postoperative adjacent vertebral instability than the UBE group, and the difference was statistically significant (P < 0.05).

Conclusion
With appropriate indications, the open PLIF group and the UBE group had similar short- and medium-term clinical outcomes for the treatment of lumbar spinal stenosis, but patients in the UBE group had better symptomatic improvement than the open PLIF group at 3 months postoperatively, and the effect on postoperative adjacent vertebral instability was smaller in the endoscopic group than in the open PLIF group.
Optimizing detection of Alzheimer’s disease in mild cognitive impairment: a 4-year biomarker study of mild behavioral impairment in ADNI and MEMENTO
Authors: Ismail Zahinoor , Leon Rebeca , Creese Byron , Ballard Clive , Robert Philippe , Smith Eric E. 
Published: July 2023

Abstract
Background
Disease-modifying drug use necessitates better Alzheimer disease (AD) detection. Mild cognitive impairment (MCI) leverages cognitive decline to identify the risk group; similarly, mild behavioral impairment (MBI) leverages behavioral change. Adding MBI to MCI improves dementia prognostication over conventional approaches of incorporating neuropsychiatric symptoms (NPS). Here, to determine if adding MBI would better identify AD, we interrogated associations between MBI in MCI, and cerebrospinal fluid biomarkers [β-amyloid (Aβ), phosphorylated-tau (p-tau), and total-tau (tau)-ATN], cross-sectionally and longitudinally.

Methods
Data were from two independent referral-based cohorts, ADNI (mean[SD] follow-up 3.14[1.07] years) and MEMENTO (4.25[1.40] years), collected 2003–2021. Exposure was based on three-group stratification: 1) NPS meeting MBI criteria; 2) conventionally measured NPS (NPSnotMBI); and 3) noNPS. Cohorts were analyzed separately for: 1) cross-sectional associations between NPS status and ATN biomarkers (linear regressions); 2) 4-year longitudinal repeated-measures associations of MBI and NPSnotMBI with ATN biomarkers (hierarchical linear mixed-effects models-LMEs); and 3) rates of incident dementia (Cox proportional hazards regressions).

Results
Of 510 MCI participants, 352 were from ADNI (43.5% females; mean [SD] age, 71.68 [7.40] years), and 158 from MEMENTO (46.2% females; 68.98 [8.18] years). In ADNI, MBI was associated with lower Aβ42 (standardized β [95%CI], -5.52% [-10.48-(-0.29)%]; p = 0.039), and Aβ42/40 (p = 0.01); higher p-tau (9.67% [3.96–15.70%]; p = 0.001), t-tau (7.71% [2.70–12.97%]; p = 0.002), p-tau/Aβ42 (p < 0.001), and t-tau/Aβ42 (p = 0.001). NPSnotMBI was associated only with lower Aβ42/40 (p = 0.045). LMEs revealed a similar 4-year AD-specific biomarker profile for MBI, with NPSnotMBI associated only with higher t-tau. MBI had a greater rate of incident dementia (HR [95%CI], 3.50 [1.99–6.17; p < 0.001). NPSnotMBI did not differ from noNPS (HR 0.96 [0.49–1.89]; p = 0.916). In MEMENTO, MBI demonstrated a similar magnitude and direction of effect for all biomarkers, but with a greater reduction in Aβ40. HR for incident dementia was 3.93 (p = 0.004) in MBI, and 1.83 (p = 0.266) in NPSnotMBI. Of MBI progressors to dementia, 81% developed AD dementia.

Conclusions
These findings support a biological basis for NPS that meet MBI criteria, the continued inclusion of MBI in NIA-AA ATN clinical staging, and the utility of MBI criteria to improve identification of patients for enrollment in disease-modifying drug trials or for clinical care.
The new world of RNA diagnostics and therapeutics
Authors: Blandino Giovanni , Dinami Roberto , Marcia Marco , Anastasiadou Eleni , Ryan Brid M. , Palcau Alina Catalina , Fattore Luigi , Regazzo Giulia , Sestito Rosanna , Loria Rossella , Díaz Méndez Ana Belén , Cappelletto Maria Chiara , Pulito Claudio , Monteonofrio Laura , Calin George A. , Sozzi Gabriella , Cheong Jit Kong , Aharonov Ranit , Ciliberto Gennaro 
Published: July 2023

AbstractThe 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World of RNA diagnostics and therapeutics” highlightes the significant progress in the RNA field made over the last years. Research moved from pure discovery towards the development of diagnostic biomarkers or RNA-base targeted therapies seeking validation in several clinical trials. Non-coding RNAs in particular have been the focus of this workshop due to their unique properties that make them attractive tools for the diagnosis and therapy of cancer.This report collected the presentations of many scientists from different institutions that discussed recent oncology research providing an excellent overview and representative examples for each possible application of RNA as biomarker, for therapy or to increase the number of patients that can benefit from precision oncology treatment.In particular, the meeting specifically emphasized two key features of RNA applications: RNA diagnostic (Blandino, Palcau, Sestito, Díaz Méndez, Cappelletto, Pulito, Monteonofrio, Calin, Sozzi, Cheong) and RNA therapeutics (Dinami, Marcia, Anastasiadou, Ryan, Fattore, Regazzo, Loria, Aharonov).
Sertaconazole-repurposed nanoplatform enhances lung cancer therapy via CD44-targeted drug delivery
Authors: Liu Ruolan , Li Qiong , Qin Siyuan , Qiao Ling , Yang Mei , Liu Shanshan , Nice Edouard C. , Zhang Wei , Huang Canhua , Zheng Shaojiang , Gao Wei 
Published: July 2023

Abstract
Background
Lung cancer is one of the most frequent causes of cancer-related deaths worldwide. Drug repurposing and nano-drug delivery systems are attracting considerable attention for improving anti-cancer therapy. Sertaconazole (STZ), an antifungal agent, has been reported to exhibit cytotoxicity against both normal and tumor cells, and its medical use is limited by its poor solubility. In order to overcome such shortcomings, we prepared a drug-repurposed nanoplatform to enhance the anti-tumor efficiency.

Methods
Nanoplatform was prepared by thin film dispersion. Drug release studies and uptake studies were measured in vitro. Subsequently, we verified the tumor inhibition mechanisms of HTS NPs through apoptosis assay, immunoblotting and reactive oxygen species (ROS) detection analyses. Antitumor activity was evaluated on an established xenograft lung cancer model in vivo.

Results
Our nanoplatform improved the solubility of sertaconazole and increased its accumulation in tumor cells. Mechanistically, HTS NPs was dependent on ROS-mediated apoptosis and pro-apoptotic autophagy to achieve their excellent anti-tumor effects. Furthermore, HTS NPs also showed strong inhibitory ability in nude mouse xenograft models without significant side effects.

Conclusions
Our results suggest that sertaconazole-repurposed nanoplatform provides an effective strategy for lung cancer treatment.
Protocol for a systematic literature review of smartphone apps to support the self-management of rheumatic and musculoskeletal diseases: development strategies, theoretical underpinnings and barriers to engagement
Authors: Barnett Rosemarie , Clarke Christopher , Sengupta Raj , Rouse Peter C. 
Published: July 2023

Abstract
Background
Rheumatic and musculoskeletal diseases (RMDs) cause significant burden to the individual and society, requiring lifelong management and specialist healthcare resource use. Costing over 200 billion euros per year in Europe, RMDs are the most expensive of all diseases for European healthcare systems. The incidence and burden of RMDs are projected to rise with the ageing global population and increase in sedentary, obesogenic lifestyles. In parallel, there is a global crisis in the rheumatology workforce, whereby capacity to deliver specialist care is being exceeded by demand. Pervasive, scalable mobile health technologies, such as apps, are being developed to support the self-management of RMDs and reduce pressure on healthcare services. However, it is unknown whether these apps are informed by theory or their use supported by an appropriate evidence base. The purpose of this review is therefore to provide a comprehensive overview of the development strategies, interventional components and theoretical underpinnings of existing smartphone apps, designed to support the self-management of RMDs.

Methods
Searches will be conducted within PubMed, Scopus, Web of Science, Embase, MEDLINE and PsycINFO. Reference lists and citing articles of the included studies will be searched. Identified publications will be screened for eligibility by two independent reviewers. Any discrepancies between reviewers will be resolved by consensus, with input from a third reviewer if required. Data will be extracted on study designs, methods, populations, setting, utilised theoretical frameworks, intervention components, behaviour change techniques, methods to evaluate effectiveness and barriers/facilitators to intervention engagement. Exploratory outcomes include reported effectiveness, acceptability and usability. A systematic, narrative synthesis of evidence will be presented. If appropriate (depending on quality and pool of evidence identified), qualitative meta-summary techniques will be used to combine and summarise qualitative findings regarding barriers/facilitators to intervention engagement.

Discussion
The results of this systematic literature review will provide insights for healthcare professionals, researchers, app designers and policy makers, to inform future development and implementation of smartphone apps to support self-management of RMDs. Evidence gaps for future research will be identified. Findings will be disseminated through a final manuscript/publication of results and via a conference abstract, patient organisations and social media.

Systematic review registration
PROSPERO CRD42022359704.
3-D thermal structure and dehydration near the Chile Triple Junction and its relation to slab window, tectonic tremors, and volcanoes
Authors: Iwamoto Kaya , Suenaga Nobuaki , Yoshioka Shoichi , Ortega-Culaciati Francisco , Miller Matthew , Ruiz Javier 
Published: July 2023

AbstractThe southern Chile subduction zone is a complex tectonic environment, where the Chile Ridge, the Nazca (NZ) and Antarctic (AN) plates subduct underneath the South American (SA) plate. The intersection between the NZ, AN and SA plates is referred to as the Chile Triple Junction (CTJ). In this region, a gap, often referred to as a slab window, has been formed between the NZ and AN slabs due to the divergence in their plate motion velocities, with volcanoes existing mainly above the subducted NZ and AN plates. In this study, we constructed a three-dimensional thermomechanical model associated with simultaneous subduction of the NZ and AN plates near the CTJ. The results show that the current temperature distributions on the upper surface of the slabs are higher closer to the Chile Ridge, and the AN plate has a distribution of elevated temperatures relative to the NZ plate at the same depth due to the northward migration of the CTJ and the slower convergence rate of the AN plate. Moreover, we calculated the water content and dehydration gradient from the temperature distribution near the upper surface of the slab and discussed their relationship to the distribution of volcanoes. In the northern part of the model domain, high dehydration gradients were obtained below the volcanic chain. Therefore, we suggest that the water released from the slab and the mantle wedge decreased the melting point of the mantle wedge just above the slab and produced melts, which may have contributed to form the overlying volcanoes.
Open‐wedge high tibial osteotomy with a slight valgus correction from neutral limb alignment achieves clinical improvements comparable with those for knees with varus deformity
Authors: Itou Junya , Kuwashima Umito , Itoh Masafumi , Okazaki Ken 
Published: July 2023

AbstractPurposeThe effect of open‐wedge high tibial osteotomy (OWHTO) on the preoperative neutral alignment of the knee is unknown. The purpose of this study was to clarify the clinical outcome of OWHTO with neutral alignment, defined as within 4 degrees of varus.MethodsThis retrospective study included 72 knees with varus that underwent medial OWHTO. The knees were divided according to the preoperative hip‐knee‐ankle angle into a neutral alignment group (≤ 4° of varus alignment) and a varus alignment group (> 4° of varus alignment). The Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Forgotten Joint Score‐12 (FJS‐12) were evaluated preoperatively and during at least 2 years of follow‐up postoperatively.ResultsThere were no significant differences between the preoperative FJS‐12 (17.9 versus 23.7; p = 0.16) and postoperative FJS‐12 (57.3 versus 60.6; p = 0.52) or KOOS subscale scores (p > 0.05) in the neutral alignment group or the varus alignment group. Each group had a mean change in the KOOS subscale scores that exceeded the minimum clinically important difference.ConclusionThe short‐term clinical results of OWHTO for neutral alignment were as favourable as those for varus malalignment.Level of evidenceIV.
Oral semaglutide in kidney transplant recipients with metabolic syndrome: three Japanese cases
Authors: Miyazaki Ryoichi , Miyagi Kyoko 
Published: July 2023

Abstract
Background
Renal transplant recipients with chronic kidney disease often develop post-transplant diabetes mellitus or metabolic syndrome (MetS), which are poor prognostic factors after renal grafts. Although recent studies have reported the protective effects of glucagon-like peptide-1 receptor agonist (GLP-1RA) on the heart and kidneys, few have assessed its effects in renal transplant patients. Moreover, to our knowledge there have been no studies on the effects of oral GLP-1RA (semaglutide) in renal transplantation recipients in Japan.

Case presentation
Case 1 was a 52-year-old male renal transplant recipient with MetS. Semaglutide was administered orally for 12 months, starting at 3 mg/day and titrating up to 14 mg/day. Over time, his HbA1c level decreased from 5.9 to 5.5% and weight from 100.6 to 96.3 kg. No adverse events were observed. Case 2 was a 62-year-old male renal transplant recipient with MetS. Oral semaglutide was started at 3 mg/day. However, the patient had severe nausea, and the dose was reduced to 1.5 mg/day and then gradually increased to 14 mg/day for 12 months. Over time, triglyceride decreased from 308 to 277 mg/dL and weight decreased from 75.4 to 63.2 kg. Case 3 was a 59-year-old male renal transplant recipient with MetS and fatty liver. Oral semaglutide was started at 3 mg/day and titrated up to 12 mg/day for 12 months. Over time, triglyceride decreased from 205 to 119 mg/dL and weight decreased from 79.1 to 76.4 kg. No adverse events were observed.

Conclusions
In all three patients, oral semaglutide significantly reduced body weight and improved metabolic parameters. Additional studies are needed to further evaluate the efficacy of oral semaglutide and the incidence of associated adverse events in a large number of renal transplant recipients.
Trial registration: UMIN, UMIN000050853. Registered 14 April 2023—Retrospectively registered, https://center6.umin.ac.jp/cgi-bin/ctr/ctr_reg_rec.cgi
Hematemesis or hemoptysis? Pulmonary hydatidosis presenting with hemoptysis, case report
Authors: Saad Moustafa Ali , Gamal Galila , Elsabagh Yumn A. , El Gendy Hala Ibrahem 
Published: July 2023

Abstract
Background

Pulmonary hydatidosis is a zoonotic infection caused by the tapeworm of the genus Echinococcus.

Case presentation

In this case report we present a case of a 38-year-old woman presenting with hemoptysis as a manifestation of pulmonary hydatidosis. Hemoptysis was falsely interpreted at first as hematemesis leading to multiple non-indicated gastroscopies. The patient was diagnosed by pathological examination of the lobectomy sample.

Conclusions
Proper history, in differentiating hemoptysis from hematemesis, guides proper management. Also, pulmonary hydatidosis should be considered in the differential diagnosis of cavitary lung lesions, especially in endemic areas.
Giant cardiac hemangioma in the right atrium: an asymptomatic surgical case
Authors: Kondo Yuki , Yasutsune Toru , Kado Yuichiro , Jinzai Yuki , Takigawa Tomoya , Kishigami Takehiro , Inaba Yuna , Nishimura Yosuke 
Published: July 2023

Abstract
Background
Cardiac hemangiomas are rare, accounting for only 5% of benign cardiac tumors. In the past, there have been few reports of giant cardiac hemangiomas that were > 100 mm in size but were asymptomatic.

Case presentation
A 44-year-old woman presented with a large asymptomatic intracardiac mass that was accidentally detected on echocardiography. The tumor was surgically resected. During surgery, a sharply margined tumor was located in the right atrium; the tumor was histopathologically diagnosed as a cavernous hemangioma. The patient was discharged uneventfully on the 18th postoperative day. No signs of recurrence were observed at 1 year postoperatively.

Conclusions
We report on a surgical case of an asymptomatic giant cardiac hemangioma 115 mm × 92 mm in size, as measured by echocardiography. It is difficult to diagnose cardiac tumors before surgery based on symptoms and imaging. Surgical resection is the most reliable treatment because of its accurate diagnosis and favorable prognosis.
Enhanced Surgical Decision-Making Tools in Breast Cancer: Predicting 2-Year Postoperative Physical, Sexual, and Psychosocial Well-Being following Mastectomy and Breast Reconstruction (INSPiRED 004)
Authors: Xu Cai , Pfob André , Mehrara Babak J. , Yin Peimeng , Nelson Jonas A. , Pusic Andrea L. , Sidey-Gibbons Chris 
Published: July 2023

Abstract
Background
We sought to predict clinically meaningful changes in physical, sexual, and psychosocial well-being for women undergoing cancer-related mastectomy and breast reconstruction 2 years after surgery using machine learning (ML) algorithms trained on clinical and patient-reported outcomes data.

Patients and Methods
We used data from women undergoing mastectomy and reconstruction at 11 study sites in North America to develop three distinct ML models. We used data of ten sites to predict clinically meaningful improvement or worsening by comparing pre-surgical scores with 2 year follow-up data measured by validated Breast-Q domains. We employed ten-fold cross-validation to train and test the algorithms, and then externally validated them using the 11th site’s data. We considered area-under-the-receiver-operating-characteristics-curve (AUC) as the primary metric to evaluate performance.

Results
Overall, between 1454 and 1538 patients completed 2 year follow-up with data for physical, sexual, and psychosocial well-being. In the hold-out validation set, our ML algorithms were able to predict clinically significant changes in physical well-being (chest and upper body) (worsened: AUC range 0.69–0.70; improved: AUC range 0.81–0.82), sexual well-being (worsened: AUC range 0.76–0.77; improved: AUC range 0.74–0.76), and psychosocial well-being (worsened: AUC range 0.64–0.66; improved: AUC range 0.66–0.66). Baseline patient-reported outcome (PRO) variables showed the largest influence on model predictions.

Conclusions
Machine learning can predict long-term individual PROs of patients undergoing postmastectomy breast reconstruction with acceptable accuracy. This may better help patients and clinicians make informed decisions regarding expected long-term effect of treatment, facilitate patient-centered care, and ultimately improve postoperative health-related quality of life.
PREVENTIVE ZINC SUPPLEMENTATION EFFECT ON REDOX STATUS IN RAT MODEL OF MAFLD
Authors: Nikonorova Eugenia R. , Nikonorov Alexandr A. , Popova Elizaveta V. , Agletdinov Eduard F. , Sinitskii Anton I. , Tinkov Alexey A. 
Published: July 2023

Background. Oxidative stress plays an important role in the pathogenesis of metabolic-associated fatty liver disease (MAFLD). Antioxidant trace elements as cofactors of antioxidant enzymes and metalloproteins are involved in this process. Zinc being an important antioxidant may have a positive effect on the treatment of liver pathology. The study aimed to assess the effect of preventive zinc supplementation on MAFLD in rats.
Materials and Methods. A total of 26 three-month-old female Wistar rats were used in the present study. The activity of the antioxidant enzymes superoxide dismutase and catalase, some redox status markers, such as ceruloplasmin, oxidized tryptophan, dithyrosines, total thiols, carbonyls, TBARS, and uric acid were evaluated. Oxidative stress biomarkers were studied spectrophotometrically.
Results. MAFLD was accompanied by hyperuricemia and a decrease in serum dityrosines. The addition of Zn to the diet prevented the development of steatosis, decreased the level of oxidized tryptophan in the liver, and paradoxically caused hyperuricemia in the MAFLD model used. Zn supplementation had a positive effect on the prevention of MAFLD, had a little effect on redox status of animals but caused paradoxical hyperuricemia. Future studies are needed to establish the mechanisms of the Zn effect at the cellular level.