bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid double‐dermal flap technique for vest‐over‐pants‐closure correction of depressed abdominal scars
Authors: Gelidan Adnan G. 
Published: May 2023

AbstractSurgical procedures performed during neonatal period or childhood that result in vertical midline, transverse left upper quadrant, or central upper abdominal scars create significant psychological concerns in adulthood. Various surgical techniques correct depressed scars, including scar revision, Z‐ or W‐plasty flaps, sub‐incision tunnelling, fat grafting, and autologous or alloplastic dermal grafting. This article describes a novel technique for repairing depressed abdominal scars using hybrid double‐dermal flaps. We included patients with psychosocial concerns who underwent abdominal scar revision because of wedding plans. Hybrid local de‐epithelised dermal flaps were used to correct the depression of the abdominal scar. Superior and inferior skin flaps, medial and lateral to the depressed scar, were de‐epithelised for 2 to 3 cm and sutured using the vest‐over‐pants technique with 2/0 nylon permanent sutures. Six female patients who want to marry were included in this study. Depressed abdominal scars were successfully fixed using hybrid double‐dermal flaps, either from the superior‐inferior aspect for transverse scars or from the medial‐lateral aspect for vertical scars. No postoperative complications were noted, and the patients were satisfied with the outcomes. De‐epithelialised double‐dermal flaps in the vest‐over‐pants technique are an effective and valuable surgical technique for correcting depressed scars.
Gene therapy for diabetic foot ulcers: Interim analysis of a randomised, placebo‐controlled phase 3 study of VM202 (ENGENSIS), a plasmid DNA expressing two isoforms of human hepatocyte growth factor
Authors: Perin Emerson , Loveland Lacey , Caporusso Joseph , Dove Cyaandi , Motley Travis , Sigal Felix , Vartivarian Mher , Oliva Francisco , Armstrong David G ,   the VMNHU‐003 study group
Published: May 2023

AbstractTo evaluate the status of a 7‐month phase 3 study conducted to test the effect of intramuscular injections of VM202 (ENGENSIS), a plasmid DNA encoding human hepatocyte growth factor, into the calf muscles of chronic nonhealing diabetic foot ulcers with concomitant peripheral artery disease. The phase 3 study, originally aimed to recruit 300 subjects, was discontinued because of slow patient recruitment. An unprespecified interim analysis was performed for the 44 subjects enrolled to assess the status and determine the future direction. Statistical analyses were carried out for the Intent‐to‐Treat (ITT) population and separately for subjects with neuroischemic ulcers, using a t‐test and Fisher's exact test. A logistic regression analysis was also conducted. VM202 was safe and potentially should have benefits. In the ITT population (N = 44), there was a positive trend toward closure in the VM202 group from 3 to 6 months but with no statistical significance. Levels of ulcer volume or area were found to be highly skewed between the placebo and VM202 groups. Forty subjects, excluding four outliers in both arms, showed significant wound‐closing effects at month 6 (P = .0457). In 23 patients with neuroischemic ulcers, the percentage of subjects reaching complete ulcer closure was significantly higher in the VM202 group at months 3, 4, and 5 (P = .0391, .0391, and .0361). When two outliers were excluded, a significant difference was evident in months 3, 4, 5, and 6 (P = .03 for all points). A potentially clinically meaningful 0.15 increase in Ankle‐Brachial Index was observed in the VM202 group at day 210 in the ITT population (P = .0776). Intramuscular injections of VM202 plasmid DNA to calf muscle may have promise in the treatment of chronic neuroischemic diabetic foot ulcers (DFUs). Given the safety profile and potential healing effects, continuing a larger DFU study is warranted with modifications of the current protocol and expansion of enrolling sites.
Should Political Philosophers Attend to Victim Testimony?
Authors: Engelstad Ane 
Published: May 2023

ABSTRACTThere is a growing recognition that victims of injustice may have privileged access to knowledge about the injustices they experience, and that injustices are perpetuated through silencing victims by taking them to be less credible, and through denying them the platform and capacity to speak. However, these are not ideas that political philosophers tend to engage with in a sustained manner, to the extent that they alter methodological approaches to be systematically attentive to victim testimony. In this article, I provide two arguments in favour of political philosophers attending to victim testimony, one moral, one epistemic, and demonstrate that the moral case has little purchase, but that the epistemic case is more successful. Then, I present the strongest case against including victim testimony in political philosophy, and I argue that it does not hold up to scrutiny. In so doing, I demonstrate how methodological practices in political philosophy could be improved through drawing on feminist social epistemology; attending to victim testimony can enrich political philosophy in epistemically acceptable ways, and it also corrects for a range of potential biases.
Electrophysiological study prior to planned pulmonary valve replacement in patients with repaired tetralogy of Fallot
Authors: Bouyer Benjamin , Jalal Zakaria , Daniel Ramirez F. , Derval Nicolas , Iriart Xavier , Duchateau Josselin , Roubertie François , Tafer Nadir , Tixier Romain , Pambrun Thomas , Cheniti Ghassen , Ascione Ciro , Yokoyama Masaaki , Kowalewski Christopher , Buliard Samuel , Chauvel Rémi , Arnaud Marine , Hocini Mélèze , Haïssaguerre Michel , Jaïs Pierre , Cochet Hubert , Thambo Jean‐Benoit , Sacher Frederic 
Published: May 2023

AbstractAimVentricular arrhythmias (VAs) are the most common cause of death in patients with repaired Tetralogy of Fallot (rTOF). However, risk stratifying remains challenging. We examined outcomes following programmed ventricular stimulation (PVS) with or without subsequent ablation in patients with rTOF planned for pulmonary valve replacement (PVR).MethodsWe included all consecutive patients with rTOF referred to our institution from 2010 to 2018 aged ≥18 years for PVR. Right ventricular (RV) voltage maps were acquired and PVS was performed from two different sites at baseline, and if non‐inducible under isoproterenol. Catheter and/or surgical ablation was performed when patients were inducible or when slow conduction was present in anatomical isthmuses (AIs). Postablation PVS was undertaken to guide implantable cardioverter‐defibrillator (ICD) implantation.ResultsSeventy‐seven patients (36.2 ± 14.3 years old, 71% male) were included. Eighteen were inducible. In 28 patients (17 inducible, 11 non‐inducible but with slow conduction) ablation was performed. Five had catheter ablation, surgical cryoablation in 9, both techniques in 14. ICDs were implanted in five patients. During a follow‐up of 74 ± 40 months, no sudden cardiac death occurred. Three patients experienced sustained VAs, all were inducible during the initial EP study. Two of them had an ICD (low ejection fraction for one and important risk factor for arrhythmia for the second). No VAs were reported in the non‐inducible group (p < .001).ConclusionPreoperative EPS can help identifying patients with rTOF at risk for VAs, providing an opportunity for targeted ablation and may improve decision‐making regarding ICD implantation.
Upstream conduct and price authority with competing organizations
Authors: Andreu Enrique , Neven Damien , Piccolo Salvatore , Venturini Roberto 
Published: May 2023

AbstractWe characterize the degree of price authority that competing upstream principals award their downstream agents in a setting where these agents own private information about demand and incur nonverifiable distribution costs. Principals cannot internalize these costs through monetary incentives and design “permission sets” from which agents choose prices. The objective is to understand the forces shaping delegation and the constraints imposed on equilibrium prices. When principals behave noncooperatively, agents are biased toward excessively high prices because they pass on distribution costs to consumers. Hence, the permission set only features a price cap that is more likely to bind as products become closer substitutes, in sectors where distribution is sufficiently costly, and when demand is not too volatile. By contrast, when principals behave cooperatively, the optimal delegation scheme is richer and more complex. Because principals want to charge the monopoly price, the optimal permission set features a price floor when the distribution cost is sufficiently low, it features instead full discretion for moderate values of this cost, and only when it is high enough, a price cap is optimal. Surprisingly, while competition (as captured by stronger product substitutability) hinders delegation in the noncooperative regime, the opposite occurs when principals maximize industry profit.
Philosophical health: Unveiling the patient's personal philosophy with a person‐centred method of dialogue
Authors: de Miranda Luis , Loughlin Michael 
Published: May 2023

AbstractGrounded in ideas about sense‐making and whole‐person care with a long intellectual heritage, the movement for Philosophical Health—with its specific conceptions of philosophical care and counselling—is a relatively recent addition to the ongoing debate about understanding better the perspectives of patients to improve health practice. This article locates the development of this movement within the context of broader discussions of person‐centred care (PCC), arguing that the approach advocated by defenders of philosophical health can provide a straightforward method for implementing PCC in actual cases. This claim is explained and defended with reference to the SMILE_PH method created by Luis de Miranda (Sense‐Making Interviews Looking at Elements of Philosophical Health), an approach recently trialled convincingly with people living with traumatic spinal cord injury.
Outcomes among hospitalized patients with dementia and behavioral disturbances when physical restraints are introduced
Authors: Singh Amteshwar , Gupta Ishaan , Wright Scott Mitchell , Harris Che Matthew 
Published: May 2023

AbstractBackgroundPhysical restraint use among patients hospitalized with dementia and behavioral disturbances has not been studied nationally in the United States.MethodsNational Inpatient Sample database years 2016 through 2020 were used to compare physically restrained and unrestrained patients with dementia and behavioral disturbances. Multivariable regression analyses were used to assess patient outcomes.ResultsThere were 991,605 patients coded for dementia with behavioral disturbances. Among these, physical restraints were used with 64,390 (6.5%) and not with 927,215 (93.5%). Patients in the restrained group were younger (mean age standard error: 78.7 0.25 vs. ; p < 0.01) and more often male (59.0% vs. 45.8%; p < 0.01) compared to the unrestrained group. A higher proportion of Black patients were in the restrained group (15.2% vs. 11.8%; p < 0.01). Larger hospitals also made up a more significant proportion of restrained versus unrestrained patients (53.3% vs. 45.1%; p < 0.01). Those with physical restraints had longer lengths of stays (adjusted mean difference [aMD] = 2.6 days CI [2.2–3.0]; p < 0.01) and higher total hospital charges (aMD = $13,150 CI [10,827‐15,472]; p < 0.01). There were similar adjusted odds for in‐hospital mortality (adjusted odds ratio [aOR] = 1.0 [CI 0.95–1.1]; p = 0.28) and lower odds of being discharged to home after hospitalization (aOR = 0.74 [0.70–0.79]; <0.01) for patients with physical restraints compared to those without.ConclusionAmong patients hospitalized with dementia and behavioral disturbances, those with physical restraints had greater hospital resource utilization outcomes. Attempts to limit physical restraint use whenever possible may improve outcomes in this vulnerable population.
Grand challenges and platform ecosystems: Scaling solutions for wicked ecological and societal problems
Authors: Ritala Paavo 
Published: May 2023

AbstractThe persistence of grand societal and environmental challenges demands attention from innovation management scholars and practitioners to find effective resolutions. Grand challenges are complex, uncertain, and evaluative and cannot be resolved by individual actors or organizations. Therefore, conventional forms of organizing do not suffice in the face of wicked problems like climate change or global inequality, which require continuous and varied attention and inputs. In this catalyst article, I argue that platform ecosystems—communities and groups of actors in different markets orchestrated through a digital platform and driven by combinations of economic and prosocial incentives—are an organizing form that can help effectively scale solutions for grand societal and environmental problems. This potential is based on three organizational elements of platform ecosystems: (1) coordination structures for orchestrating complementary inputs, (2) instigation and maintenance of collective action, and (3) generativity potential. I illustrate these arguments with practical examples of two platforms with the potential to resolve specific grand challenges: Patient Innovation, which orchestrates a community of innovators seeking to help treatment of chronic and rare diseases, and Excess Materials Exchange, which provides matching solutions to address the challenges associated with industrial material waste. The article concludes with an agenda for future research and practice on platform ecosystems and grand challenges.
Efficacy of high‐level disinfection of endoscopes contaminated with Streptococcus equi subspecies equi with 2 different disinfectants
Authors: Nadruz Veridiana , Beard Laurie A. , Delph‐Miller Katherine M. , Larson Robert L. , Bai Jianfa , Chengappa Muckatira M. 
Published: May 2023

AbstractBackgroundPrevention of spread of Streptococcus equi subspecies equi (S. equi) after an outbreak is best accomplished by endoscopic lavage of the guttural pouch, with samples tested by culture and real time, quantitative polymerase chain reaction (qPCR). Disinfection of endoscopes must eliminate bacteria and DNA to avoid false diagnosis of carrier horses of S. equi.Hypothesis/ObjectivesCompare failure rates of disinfection of endoscopes contaminated with S. equi using 2 disinfectants (accelerated hydrogen peroxide [AHP] or ortho‐phthalaldehyde [OPA]). The null hypothesis was that there would be no difference between the AHP and OPA products (based on culture and qPCR results) after disinfection.MethodsEndoscopes contaminated with S. equi were disinfected using AHP, OPA or water (control). Samples were collected before and after disinfection and submitted for detection of S. equi by culture and qPCR. Using a multivariable logistic regression model‐adjusted probability, with endoscope and day as controlled variables, the probability of an endoscope being qPCR‐positive was determined.ResultsAfter disinfection, all endoscopes were culture‐negative (0%). However, the raw unadjusted qPCR data were positive for 33% AHP, 73% OPA, and 71% control samples. The model‐adjusted probability of being qPCR‐positive after AHP disinfection was lower (0.31; 95% confidence interval [CI], −0.03‐0.64) compared to OPA (0.81; 95% CI, 0.55‐1.06), and control (0.72; 95% CI, 0.41‐1.04).Conclusion and Clinical ImportanceDisinfection using the AHP product resulted in significantly lower probability of endoscopes being qPCR‐positive compared to the OPA product and control.
Embryonic inhibition of colony‐stimulating factor 1 receptor impacts craniofacial morphogenesis
Authors: Nagra Ashina , Katsube Motoki , Gao Wade , Rosin Jessica M. , Vora Siddharth R. 
Published: May 2023

AbstractObjectivesColony‐stimulating factor‐1 receptor (CSF1R) is vital for the recruitment of monocytes, and their proliferation and differentiation into functional osteoclasts. Mouse studies, where CSF1R and its cognate ligand are absent, have significant craniofacial phenotypes, but these have not been studied in detail.Materials and MethodsPregnant CD1 mice were fed diets laced with CSF1R inhibitor—PLX5622 starting at embryonic day 3.5 (E3.5) up to birth. Pups were collected at E18.5 to study CSF1R expression using immunofluorescence. Additional pups were studied at postnatal day 21 (P21) and P28 using microcomputed tomography (μCT) and Geometric Morphometrics, to evaluate craniofacial form.ResultsCSF1R‐positive cells were present throughout the developing craniofacial region, including the jaw bones, surrounding teeth, tongue, nasal cavities, brain, cranial vault and base regions. Animals exposed to the CSF1R inhibitor in utero had severe depletion of CSF1R‐positive cells at E18.5 and had significant differences in craniofacial form (size and shape) at postnatal timepoints. Centroid sizes for the mandibular and cranio‐maxillary regions were significantly smaller in CSF1R‐inhibited animals. Proportionally, these animals had a domed skull, with taller and wider cranial vaults and shortening of their midfacial regions. Mandibles were smaller vertically and anterio‐posteriorly, with proportionally wider inter‐condylar distances.ConclusionsEmbryonic inhibition of CSF1R impacts postnatal craniofacial morphogenesis, with significant influences on the mandibular and cranioskeletal size and shape. These data indicate that CSF1R plays a role in early cranio‐skeletal patterning, likely through osteoclast depletion.
Percutaneous Full Endoscopic Lumbar Discectomy for Symptomatic Adjacent Segment Disease after Lumbar Fusion in Elderly Patients
Authors: Feng Pin , Kong Qingquan , Zhang Bin , Liu Junlin , Ma Junsong , Hu Yuan 
Published: May 2023

PurposeTreatment of adjacent segment disease (ASD) is still controversial. The aim of this study was to evaluate the short‐term efficacy and safety and to analyze the technical advantages, surgical approach, and indications of percutaneous full endoscopic lumbar discectomy (PELD) in the treatment of ASD after lumbar fusion in elderly patients.MethodsA retrospective of 32 patients with symptomatic ASD were accepted for PELD from October 2017 to January 2020. All patients used the transforaminal approach and recorded the operation time and intraoperative conditions. Preoperative, 3, 12, 24 months of postoperative and at the last follow‐up, the pain of back and leg of visual analog scale (VAS), Oswestry dysfunction index (ODI), and Japanese Orthopaedic Association Assessment Treatment Score (JOA) were performed, and the paired student's t test was used to the compare the continuous variables preoperatively and postoperatively. The clinical efficacy was evaluated according to MacNab standards. The lumbar MRI was performed to evaluate the decompression of the nerve roots, and the lumbar lateral and dynamic X‐rays were performed to evaluate the stability of the surgical segment.ResultsA total of 32 patients were included in the study, including 17 males and 15 females. The follow‐up time ranged from 24 to 50 months, with an average of (33.2 ± 8.1) months and an average operation time of (62.7 ± 28.1) minutes. Compared to preoperatively, the VAS score of the back and leg pain (p < 0.05), ODI (p < 0.05), and JOA (p < 0.05) postoperatively were significantly improved. At the last follow‐up, according to the modified MacNab standard assessment, 24 cases were excellent, five cases were good, and three cases were fair, the excellent and good rate was 90.65%. As for complications, one case had a small rupture of the dural sac during the operation, which was found but not repaired during the operation, and one case recurred after the operation. At the last follow‐up, there were three cases of intervertebral instability.ConclusionPELD showed satisfactory short‐term efficacy and safety in the management of ASD after lumbar fusion in elderly patients. Therefore, PELD might be an alternative choice for elderly patients with symptomatic ASD after lumbar fusion, but surgical indications must be strictly controlled.
Optimization of light/dark cycle in an extended photoperiod‐based speed breeding protocol for grain legumes
Authors: Mitache Mohammed , Baidani Aziz , Houasli Chafika , Khouakhi Khadija , Bencharki Bouchaib , Idrissi Omar 
Published: May 2023

AbstractThe use of high‐performing varieties could contribute to increase food legume production and meet the population demand. However, the long process of conventional breeding is a serious limitation that needs further acceleration of genetic improvement. Speed breeding based on extended photoperiod is one of the techniques that allows rapid generation turnover by accelerating the plant life cycle. The present study focused on optimizing the duration of extended photoperiod for lentil, chickpea and faba bean in a growth chamber with light‐emitting diode (LED) light sources. Significant differences in growth rate, biomass production, phenology, physiology, plant injury and yield components were observed depending on light phase durations (22, 18 and 14 h). Twenty‐two hours of light resulted in earlier flowering and maturity, but higher stress symptoms than the other two light treatments. However, vegetative development was almost normal with limited stress under 14 h of light, but late flowering and maturity. Interestingly, good plant establishment with limited stress and shorter vegetative cycle was observed under 18 h of light. Therefore, a photoperiod of 18 h of light/6 h of darkness could be advised for a rapid breeding protocol.
Widespread keratinocytic epidermal nevus with an associated chylous pericardial effusion
Authors: Rowe Georgina , Snyder Kristen M. , Treat James R. 
Published: May 2023

AbstractA 17‐year‐old male presented for review of a widespread keratinocytic epidermal nevus (KEN) in the setting of a chronic pericardial effusion. Biopsy of the epidermal nevus revealed a KRAS mutation. Pericardiocentesis revealed a chylous effusion and magnetic resonance lymphangiogram demonstrated an underlying lymphatic malformation. There are rare case reports of KEN with an associated KRAS mutation. This case highlights the importance of being alert to epidermal nevus syndrome, particularly in patients with a widespread nevus and seemingly unrelated pathology.
Rationally Facing Death: Fear and Other Alternatives
Authors: Cholbi Michael 
Published: May 2023

AbstractExplaining what emotions or attitudes it is rational for humans to have toward our own deaths and toward their mortality has been a central task within most philosophical traditions. This article critically examines the rationality of five emotions or attitudes that might be taken toward death: fear, insofar as death can harm us by reducing our overall level of well‐being; the related attitude of existential terror, a feeling of dismay or uncanniness directed at the prospect of our eventual non‐existence; regret, directed at our being constituted as mortals; anger or resentment; and gratitude. Our conclusion is that there is in all likelihood no specific emotion or attitude that we are rationally required to take toward death or mortality. Neither anger nor gratitude are rational attitudes toward death, and while fear, existential terror, and regret are stronger candidates for being rational attitudes toward death, it proves difficult to show that death rationally requires any particular emotions or attitudes on our part.