bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beneficial effects of statins on adropin level in patients with arterial hypertension
Authors: Pokrovska N.K. , Sklyarov E.Y. 
Published: May 2023

Introduction. Adropin is a new secretory hormone that takes part in the regulation of energy homeostasis. Hormone is known to have positive effects on endothelial cell proliferation and prevention of atherosclerosis, and low adropin level may be a risk factor and potential predictor of atherosclerosis. Arterial hypertension (AH), which remains one of the most common somatic pathologies among middle-aged and older people, plays an important role in predicting cardiovascular morbidity and mortality. A number of medications that are used as antihypertensive therapy contribute to an increase in the content of adropin. At the same time there are not enough studies on the effect of statins on the content of adropin.
Aim of the study.To investigate the effects of statins on adropin level in patients with AH.
Material and methods. 70 patients with hypertension aged 62,1 ± 9,9 years were examined. They were divided into 2 groups: 1 group – patients with AH, overweight and obesity who did not take statins (n=40); group 2 – persons with AH, overweight and obesity who took statins (n=30). All individuals underwent determination of basic indicators of biochemical blood analysis, lipid profile (total cholesterol (TC), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), triglycerides (TG), atherogenicity ratio). The level of adropin was determined by enzyme immunoassay (Finetest Elisa Kit) in blood serum.
Results. Systolic blood pressure (BP) was significantly higher in group 1 individuals (p<0.05), while diastolic BP remained unchanged (p>0.05). Among patients who took statins, a significantly lower level of TC, LDL, atherogenicity ratio (p<0.01), HDL (p<0.05) was found, while the level of TG remained unchanged.
Taking statins and achieving the target level of LDL improves the prognosis of patients with cardiovascular pathology, as evidenced by a significant increase in the content of adropin in blood serum in patients of the 2nd group. In women who took statins, a direct correlation was found between the level of adropin and HDL (r=0.609; p<0.05).
Conclusions. Taking statins is associated with significantly higher levels of adropin in patients with AH compared to individuals who did not take these drugs. A direct correlation was noted between the level of adropin and HDL in women who took statins. Statins effectively reduce atherogenic fractions of cholesterol and help to increase the concentration of adropin in blood serum.
EFFICIENCY OF EARLY REHABILITATION OF PATIENTS AFTER ISCHEMIC STROKE
Authors: Nazhar Saleh S. Kh. , Seleznyova S. V. , Kozynskyi O. V. , Mamedalieva Sevinj Ali-Kyzy , Hira Harpreet Singh 
Published: May 2023

Introduction: the relevance of determining the effectiveness of early rehabilitation of patients after an ischemic stroke is high, as it solves a number of important medical and social problems of society.
The aim: to determine the possibilities and effectiveness of early rehabilitation of patients after an ischemic stroke according to the data of literary sources.
Materials and methods: the research was conducted based on the results of the analysis of the world results of scientific research and the existing mechanisms and documents of international societies for determining the possibilities and effectiveness of early rehabilitation of patients after an ischemic stroke. The search for scientific information was performed using domestic and foreign Internet resources of Google Scholar, PubMed, Medscape, Scopus and Web of Science databases, etc.
The results of the study: It was determined that the primary and quite effective measure in the treatment of patients after an ischemic stroke is the early start of rehabilitation measures, which improves the survival of brain cells due to an increase in cerebral blood flow, which reduces ischemic necrosis of neurons and revitalizes part of neurons and significantly reduces the post-stroke level disability of patients. It was established that a significant yet undetermined issue in early rehabilitation is the effectiveness of early mobilization and its intensity, and the effectiveness of the rehabilitation strategy is entirely based on the correct combination of the time from the onset of the stroke and the intensity of mobilization
Conclusions: the study determined that early rehabilitation intervention in ischemic stroke is significantly effective and economically feasible, and the effectiveness and feasibility of early intensive mobilization is currently a rather controversial issue.
EXAMINATION DIRECTIONS AS A COMPONENT OF PHYSICAL THERAPY, FOR CHILDREN WITH BRONCHOPULMONARY DISEASES FROM THE POINT OF VIEW OF THE INTERNATIONAL CLASSIFICATION OF FUNCTIONING, DISABILITY AND HEALTH
Authors: Ivasyk N. O. 
Published: May 2023

Introduction. The Ministry of Economy of Ukraine, by its order No. 810-22 of April 9, 2022, approved the International Classification of Functioning, Limitations of Vital Activities and Health (ICF) as National Classifier NC 030:2022. This, in turn, requires appropriate approaches to both the entire rehabilitation process and its components.
Purpose: to model the components of examination directions, as a component of the physical therapy program, for children with bronchopulmonary diseases, according to the international classification of functioning, limitations of life activities and health.
Methods: General and specialized methods of cognition: analysis, generalization, systematization and comparison of information from scientific and methodical literature on the problems of physical therapy in bronchopulmonary diseases.
Results. Rehabilitation examination of children with bronchopulmonary diseases includes both objective and subjective assessments, as well as observations, which are interconnected. Changing the focus from the classification of «disease consequences» to «health components», which is the basis of the ICF, requires looking at the examination component in the process of physical therapy from the side of the health components of a child with bronchopulmonary diseases. Based on this, we considered the examination as a component of the physical therapy program for children with bronchopulmonary diseases, classified using the ICF model. In our approach, we determined the main directions of the examination, based on the components of the ICF, since when selecting tests and scales, the child’s age and development must be taken into account first and foremost.
Conclusions. Rehabilitation examination is a component of physical therapy, which is carried out with the aim of determining a rehabilitation diagnosis and is based on subjective, objective assessments and observational data. In this work, we identified the main directions for choosing examination methods based on ICF, which will contribute to the selection of examination tools, determining their priorities, and formulating a categorical profile of patients with bronchopulmonary diseases.
Effects of repetitive head trauma on symptomatology of subsequent sport-related concussion
Authors: Quinones Addison , Young Tirone , Schupper Alexander J. , Ali Muhammad , Hrabarchuk Eugene I. , Lamb Colin D. , Genadry Lisa , Kalagara Roshini , Asfaw Zerubabbel K. , Gometz Alex , Lovell Mark , Choudhri Tanvir F. 
Published: May 2023

OBJECTIVE
Adolescent participation in athletics continues to grow, leading to an increasing incidence of sports-related concussion (SRC). The current literature suggests that a greater number of prior concussions positively correlates with a greater number of total symptoms, but the specific concussion-related symptoms are not as well defined. The current study investigated the effects of prior recurrent head injury on the symptom profiles of student-athletes after another suspected concussion.

METHODS
A multicenter database consisting of 25,815 Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) results was filtered for student-athletes aged 12–22 years old who competed in 21 different sports. Patients were separated into 2 cohorts: athletes reporting a single prior concussion (SRC1) and athletes reporting 2 or more prior concussions (SRC2+). Comparisons were assessed for differences in 22 symptoms and 4 symptom clusters at baseline, first postinjury test (PI1), and second postinjury test (PI2) by using univariate and multivariate analyses.

RESULTS
No differences were seen between SRC1 (n = 2253) and SRC2+ (n = 976) at baseline. At PI1, the SRC2+ group (n = 286) had lower severity of headaches (p = 0.04) but increased nervousness (p = 0.042), irritability (p = 0.028), sadness (p = 0.028), visual problems (p = 0.04), and neuropsychiatric symptoms (p = 0.009) compared with SRC1 (n = 529). Multivariate analysis revealed decreased headache severity with increased prior concussion (β = −0.27,95% CI −0.45 to −0.09, p = 0.003). Multivariate analysis at PI2 demonstrated the SRC2+ cohort (n = 130) had increased cognitive (β = 1.22, 95% CI 0.27–2.18, p = 0.012), sleep (β = 0.63, 95% CI 0.17–1.08, p = 0.007), and neuropsychiatric (β = 0.67,95% CI 0.14–1.2,0.014) symptoms compared with SRC1 (n = 292).

CONCLUSIONS
At longitudinal follow-up, patients with a history of recurrent concussions reported greater symptom burden in cognitive, sleep, and neuropsychiatric symptom clusters but not migraine symptoms. This is an important distinction because migraine symptoms are often more easily distinguishable to patients, parents, and physicians. Careful assessment of specific symptoms should be considered in patients with a history of recurrent head injury prior to return to play.
Healthcare disparities in pediatric neurosurgery: a scoping review
Authors: Maddy Krisna , Eliahu Karen , Bryant Jean-Paul , Garcia Roxanna , Du Rebecca , Lam Sandi , Niazi Toba N. 
Published: May 2023

OBJECTIVE
The aim of this scoping review was to identify relevant articles that have contributed to the body of knowledge describing pediatric neurosurgical healthcare disparities. Identifying healthcare disparities in pediatric neurosurgery is essential to understanding how to best provide care for this unique patient population. Although it is undoubtedly important to increase the knowledge of pediatric neurosurgical healthcare disparities, it is also important to understand the current state of the literature.

METHODS
This scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines. The search terms "pediatric neurosurgical disparities" and "pediatric neurosurgical inequities" were entered into the following databases: PubMed, Scopus, and Embase.

RESULTS
The initial database search returned a total of 366 results from the PubMed, Embase, and Scopus databases. One hundred thirty-seven duplicates were removed, and the remaining articles were screened by title and abstract. Articles were excluded on the basis of the inclusion and exclusion criteria. Of the remaining 229 articles, 168 were excluded. Sixty-one full-text articles were then examined for eligibility, and 28 did not reach the specified inclusion and exclusion criteria. The remaining 33 articles were included for final review. The results of the reviewed studies were stratified on the basis of disparity type.

CONCLUSIONS
Although there has been an increase in the number of publications discussing pediatric neurosurgical healthcare disparities within the last decade, there still remains a scarcity of information regarding healthcare disparities in neurosurgery. Furthermore, less information exists that specifically addresses healthcare disparities in the pediatric population.
Ventriculoperitoneal shunt survey in pediatric patients in an emergency setting: a comparison between ultra-low-dose CT using a tin filter and plain radiography
Authors: Mobini Kesheh Shahla , Gordon Murkes Lena , Svoboda Jan , Nowik Patrik , Poludniowski Gavin , Diaz Ruiz Sandra 
Published: May 2023

OBJECTIVE
The aim of this study was to investigate the diagnostic performance, effective radiation dose, and examination time of ventriculoperitoneal shunt evaluation using full-body ultra-low-dose CT (ULD CT) with a tin filter compared with digital plain radiography in a pediatric population.

METHODS
A retrospective cross-sectional study was conducted in an emergency setting. Data from 143 children were collected. Sixty were examined with ULD CT with a tin filter and 83 with digital plain radiography methods. Effective doses and times were compared between the two methods. Two observers in pediatric radiology evaluated the patient images. Clinical findings and results from shunt revision, if it was performed, were used to evaluate the diagnostic performance between modalities. An examination-room simulation was performed of the two methods to estimate representative examination times.

RESULTS
The mean effective radiation dose for ULD CT with the tin filter was estimated to be 0.29 ± 0.16 mSv compared with 0.16 ± 0.19 mSv for digital plain radiography, with both examinations associated with a very low lifetime attributable risk (< 0.01%). The shunt tip could be more reliably located with ULD CT. ULD CT also allowed assessment of additional findings to explain patient symptoms, such as a cyst at the tip of the shunt catheter and the presence of an obstructing rubber nipple in the duodenum that could not have been observed on a plain radiograph. The examination time with ULD CT of the shunt was estimated to be 20 minutes. The examination time of the shunt with digital plain radiography, including the examination itself time and transfer of the patient between rooms, was estimated to be 60 minutes.

CONCLUSIONS
ULD CT using a tin filter allows good visualization of the position or disruption of the shunt catheter that is comparable or superior to plain radiography, at a higher dose, while providing additional findings and reduced patient discomfort.
Reoperation depending on time period following pedicle subtraction osteotomy for thoracolumbar kyphosis in patients with ankylosing spondylitis
Authors: Kim Sung-Min , Kim Yong-Chan , Kim Ki-Tack , Jo Myeong-Guk , Ha Kee-Yong 
Published: May 2023

OBJECTIVE
The aim of this study was to investigate time-dependent rates and indications of unplanned reoperation and to evaluate the most common indication depending on the time interval after pedicle subtraction osteotomy (PSO) for correction of thoracolumbar kyphosis in patients with ankylosing spondylitis (AS).

METHODS
A total of 321 consecutive patients with AS (284 men; mean age 43.8 years) with thoracolumbar kyphosis who underwent PSO were included. Patients who underwent reoperation after the index surgery were divided according to the duration of the follow-up period.

RESULTS
A total of 51 patients (15.9%) underwent unplanned reoperations. The reoperation groups had greater preoperative and postoperative C7 sagittal vertical axis (SVA), and less lordotic postoperative osteotomy angle (−4.3° ± 18.6° vs −15.0° ± 13.7°, p < 0.001). The perioperative change in SVA was not significantly different between groups (−10.0 ± 7.1 cm vs −10.0 ± 5.1 cm, p = 0.970), while that in the osteotomy angle was significantly different (−22.4° ± 21.3° vs −30.0° ± 11.5°, p = 0.014). Most reoperations (45.1%; 23/51) were performed within 2 weeks of the initial operation. Within 2 weeks, the most common cause of reoperation was neurological deficit in 10 patients, with a cumulative reoperation rate of 3.2%. After 3 years, the most common complications were mechanical complications in 8 patients, accounting for 15.7% (8/51) of patients. Overall, the most common indications for reoperation were mechanical complications (17 patients; 5.3%), followed by neurological deficits (12 patients; 3.7%).

CONCLUSIONS
PSO may be the most effective surgical procedure for the correction of thoracolumbar kyphosis in patients with AS. However, 51 patients (15.9%) required an unplanned reoperation.
Mechanical complications and patient-reported outcome measures associated with high pelvic incidence and persistent pelvic retroversion: the Roussouly “false type 2” profile
Authors: Lertudomphonwanit Thamrong , Gupta Munish C. , Theologis Alekos A. , Jauregui Julio J. , Lenke Lawrence G. , Bridwell Keith H. , Wondra James P. , Kelly Michael P. 
Published: May 2023

OBJECTIVE
The objective of this paper was to report mechanical complications and patient-reported outcome measures (PROMs) for adult spinal deformity (ASD) patients with a Roussouly "false type 2" (FT2) profile.

METHODS
ASD patients treated from 2004 to 2014 at a single center were identified. Inclusion criteria were pelvic incidence ≥ 60° and a minimum 2-year follow-up. FT2 was defined as a high postoperative pelvic tilt (PT), as defined by the Global Alignment and Proportion target, and thoracic kyphosis < 30°. Mechanical complications, defined as proximal junctional kyphosis (PJK) and/or instrumentation failure, were determined and compared. Scoliosis Research Society–22r (SRS-22r) scores were compared between groups.

RESULTS
Ninety-five patients (normal PT [NPT] group 49, FT2 group 46) who met the inclusion criteria were identified and studied. Most surgeries were revisions (NPT group 30 [61%], FT2 group 30 [65%]), and most were performed via a posterior-only approach (86%) (mean ± SD 9.6 ± 5 levels). Proximal junctional angles increased after surgery in both groups, without differences between groups. Neither rates of radiographic PJK (p = 0.10), revision for PJK (p = 0.45), nor revision for pseudarthrosis (p = 0.66) were different between groups. There were no differences between groups for SRS-22r domain scores or subscores.

CONCLUSIONS
In this single-center experience, patients with high pelvic incidence fixed with persistent lumbopelvic parameter mismatch and engaged compensatory mechanisms (Roussouly FT2) had mechanical complications and PROMs not different from those with normalized alignment parameters. Compensatory PT may be acceptable in some cases of ASD surgery.
Perancangan Alat Pendeteksi Kandungan Formalin Pada Ikan Berbasis Mikrokontroler
Authors: Efriansyah Efriansyah 
Published: May 2023

Penggunaan formalin sebagai pengawet dalam bahan makanan sangat berbahaya bagi kesehatan. Keberadaan zat kimia ini masih sangat sulit untuk diidentifikasi tanpa menggunakan alat bantu. Sehingga pada penelitian ini dirancang sebuh sistem pendeteksi kandungan formalin pada ikan berbasis Mikrokontroler. Perangkat ini menggunakan sensor Grove HCHO untuk mendeteksi kandungan gas yang diperoleh oleh hasil pemanasan ikan yang mengandung bahan formalin. Sampel ikan dimasukkan ke dalam wadah yang dipanasi dengan kompor elektrik. Pengujian dalam penelitian ini dilakukan dengan mencampurkan formalin dengan kadar 0,1 ml dan 0,5 ml pada ikan. Hasil pengujian dengan menggunakan sampel yang sama dengan sepuluh kali percobaan menunjukkan bahwa dengan kandungan formalin 0,1 ml, kandungan gas yang terdeteksi sensor memiliki nilai rata-rata 62,26 ppm. Sedangkan pada pengujian 0,5 ml diperoleh nilai rata-rata 118,44 ppm.
Analisis Pelayanan Angkutan Pedesaan (Study Kasus Desa Letta, Kecamatan Lembang, Kabupaten Pinrang)
Authors: Fadly Imam , Rafli  , Indriyanti  
Published: May 2023

Penelitian ini bertujuan untuk (1) mengetahui besaran biaya operasional angkutan pedesaan, (2) mengetahui tingkat Pelayanan Moda Angkutan Pedesaan, (3) Mengetahui besaran tarif dan waktu operasional masyarakat terhadap penggunaan moda angkutan pedesaan, (4) mengetahui pengaruh penggunaan moda angkutan pedesaan terhadap tingkat kepuasan masyarakat dengan menggunakan analisis SPSS. Hasil Penelitian ini menunjukkan Biaya operasional kendaraan (BOK) angkutan Desa Letta, Kecamatan Lembang, Kabupaten Pinrang jarak tempuh tahunan 11.350 km dengan kecepatan rata-rata 30km/jam. Dengan biaya operasional tahunan (BOK)/bulan Rp. 1.257.000 dan pendapatan rata-rata/bulan Rp. 4.867.000. Untuk kinerja moda angkutan pada fasilitas moda angkutan : cukup baik 67%, baik 32% dan tidak baik 1%, keamanan penumpang untuk operasional moda angkutan : cukup aman 83% dan yang aman 17%, kecepatan moda angkutan: tidak cepat 47%, cukup cepat 40% dan cepat 13%, Fasilitas rambu jalan : tidak baik 94%, cukup baik 3%, baik 2% dan sangat baik 1% dan untuk kondisi permukaan badan jalan : tidak baik 94%, cukup baik 4% dan baik 2%. Besaran biaya operasional moda angkutan berkisar Rp. 50.000 – Rp. 100. 000 dan waktu operasional moda angkutan adalah 60-120 menit. abstrak.
ANALISIS PENJADWALAN MENGGUNAKAN APLIKASI MICROSOFT PROJECT 2010 (STUDI KASUS: RUANG TERBUKA HIJAU (RTH) KABUPATEN WAJO)
Authors: Siddiq Achmad , Rahmawati Rahmawati , Kasmaida Kasmaida 
Published: May 2023

Ruang Terbuka Hijau (RTH) terletak di Kecamatan Tempe Kabupaten Wajo tepatnya di Jl. H. A. Ninnong Melakukan Pejadwalan secara manual kurang efektif sebab banyaknya item pekerjaan. Tujuan Penelitian ini untuk mengefektifkan waktu pekerjaan penjadwalan. Pengelolaan data yang menggunakan Microsoft project 2010. Waktu pengambilan data dilakukan pada bulan Maret - April 2022 di kelurahan Teddaopu dengan menggunakan metode kuantitatif . Pada penelitian ini, data di peroleh dari pihak pengawas dan kontraktor Proyek Pembangunan Ruang Terbuka Hijau (RTH) serta pegelolaan data menggunakan aplikasi Microsoft Project 2010. Dari hasil penelitian diperoleh total lintasan kritis 54 meliputi data pekerjaan Ruang Terbuka Hijau, Adapun total litasan non kritis 62, meliputi data pekerjaan Ruang Terbuka Hijau. Dan di peroleh waktu penyelesaian proyek Ruang Terbuka Hijau selama 120 hari.
PENGENDALIAN WAKTU DAN BIAYA DENGAN METODE EARNED VALUE ANALYSIS PADA PEKERJAAN PEMBANGUNAN SUPERVISI KONSTRUKSI PENINGKATAN JALAN RUAS KOTU - LABA
Authors: Sri Rahayu Ningsi  , T M. Nashir , Kasmaida Kasmaida 
Published: May 2023

Dalam pelaksanaan proyek konstruksi memerlukan suatu manajemen yang baik agar proyek dapat mencapai suatu tujuan yang telah direncanakan. Penelitan ini bertujuan untuk mengetahui apakah pengaplikasian EVA (Earned Value Analysis) dapat mengetahui biaya pada akhir waktu penyelesaian proyek, serta mengetahui besar keterlambatan/ kemajuan pada akhir proyek pembangunan Supervisi Konstruksi Peningkatan Jalan Ruas Kotu-Laba. Jenis penelitian yang digunakan deskriptif kuantitatif. Pengambilan data dilakukan pada bulan bulan Februari sampai dengan April 2022. Hasil penelitian ini terlihat bahwa nilai ACWP < BCWS = BCWP menunjukkan biaya actual yang dikeluarkan lebih kecil dari rencana anggaran biaya (RAB). Hasil perhitungan Budget Cost for Work Schdules (BCWS) = Rp. 4.934.936.356,66, Budget Cost for Work Performance (BCWP) = Rp. 4.934.936.356,66, serta Actual Cost for Performance (ACWP) = Rp. 4.879.955.200,00. Dari segi waktu, didapat estimasi waktu total proyek (EDC) yang di tinjau pada minggu ke -23 adalah 126 hari. Dari hasil ini diketahui bahwa perkiraan proyek mengalami keterlambatan 35 hari dari jadwal rencana.