bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphology, morpho-taxometric and molecular characterization of the invasive alien species Caribbean leatherleaf slug Sarasinula plebeia (Gastropoda: Veronicellidae): a first record in southern Philippines
Authors: Dalan Loel Bacolod , Diano Michelle Anne Bernabe , Sumaya Nanette Hope Nellas 
Published: February 2023

Herein, we first report the comprehensive description of the terrestrial slug, Sarasinula plebeia (Gastropoda: Veronicellidae) by employing morphology, morpho-taxometrics and molecular analysis. A rapid survey on terrestrial slug invasive alien species (IAS) was conducted in La Dicha, Malangas, Zamboanga Sibugay, the Philippines. Obtained COI gene sequences shared 100% similarities to S. plebeia from Brazil (JX532107, KM489378), Dominica (KM489500) and Vietnam (KM489367) and further supported using Bayesian analysis thus designated as S. plebeia isolate LDZS. Notably, the first reported S. plebeia in 2013 from Batan island, Batanes, northern Philippines, characterized through COI gene markers (JQ582277, JQ582278, JQ582279) showed 100% sequence similarities to a closely related veronicellid slug, Laevecaulis alte isolates (LC636101, LC636102, LC636103, and LC636104) from Japan. Taken this into account, our S. plebeia LDZS isolated from an agricultural field is the first report in the Philippines with combined diagnostic tools for the taxon.
Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP
Authors: Sun Yuxi , Ma Mengqiu , Cao Dandan , Zheng Ancheng , Zhang Yiying , Su Yang , Wang Jianfang , Xu Yanhua , Zhou Mi , Tang Yansong , Liu Yifan , Ma Teng , Fan Aoyuan , Zhang Xiaoying , Zhu Qiaoling , Qin Jiachen , Mo Chunyang , Xu Yawei , Zhang Li , Xu Dachun , Yue Rui 
Published: February 2023

Background:
Myocardial infarction (MI) elicits cardiac fibroblast activation and extracellular matrix (ECM) deposition to maintain the structural integrity of the heart. Recent studies demonstrate that Fap (fibroblast activation protein)—a prolyl-specific serine protease—is an important marker of activated cardiac fibroblasts after MI.

Methods:
Left ventricle and plasma samples from patients and healthy donors were used to analyze the expression level of FAP and its prognostic value. Echocardiography and histological analysis of heart sections were used to analyze cardiac functions, scar formation, ECM deposition and angiogenesis after MI. RNA-Sequencing, biochemical analysis, cardiac fibroblasts (CFs) and endothelial cells co-culture were used to reveal the molecular and cellular mechanisms by which Fap regulates angiogenesis.

Results:

We found that Fap is upregulated in patient cardiac fibroblasts after cardiac injuries, while plasma Fap is downregulated and functions as a prognostic marker for cardiac repair. Genetic or pharmacological inhibition of Fap in mice significantly improved cardiac function after MI. Histological and transcriptomic analyses showed that Fap inhibition leads to increased angiogenesis in the peri-infarct zone, which promotes ECM deposition and alignment by cardiac fibroblasts and prevents their overactivation, thereby limiting scar expansion. Mechanistically, we found that BNP (brain natriuretic peptide) is a novel substrate of Fap that mediates postischemic angiogenesis. Fap degrades BNP to inhibit vascular endothelial cell migration and tube formation. Pharmacological inhibition of Fap in
Nppb
(encoding pre-proBNP) or
Npr1
(encoding the BNP receptor)-deficient mice showed no cardioprotective effects, suggesting that BNP is a physiological substrate of Fap.

Conclusions:
This study identifies Fap as a negative regulator of cardiac repair and a potential drug target to treat MI. Inhibition of Fap stabilizes BNP to promote angiogenesis and cardiac repair.
Listening to the Anthropocene: A Queda do Céu
Authors: Rabello-Mestre André , Otondo Felipe 
Published: February 2023

Abstract
This article discusses the algorithmic design and implementation of A Queda do Céu, a sound installation and kinetic sculpture related to the Soundlapse project. In it we provide an overview of the project and go on to describe the main computational challenges related to the installation, which included a variety of real-time processing, interpolation, and mapping algorithms. We contextualize the work in relation to regional ecological and political debates, as well as the global climate crisis. In doing so, we echo other sound and field-recording artists in proposing that artworks have an important function as experimental arenas in which new technological applications can be probed and where new modes of listening can be investigated, reconfigured, and exercised. In closing, we lay out an overview of the current challenges being tackled by the Soundlapse project, specifically the development of a refined version of the sonic time-lapse method that incorporates machine learning routines and user-defined spatialization capabilities.
Research e-infrastructures for open science: The national example of CSTCloud in China
Authors: Zhang Lili , Li Jianhui , Uhlir Paul F. , Wen Liangming , Wu Kaichao , Luo Ze , Liu Yude 
Published: February 2023

ABSTRACT
This paper focuses on research e-infrastructures in the open science era. We analyze some of the challenges and opportunities of cloud-based science and introduce an example of a national solution in the China Science and Technology Cloud (CSTCloud). We selected three CSTCloud use cases in deploying open science modules, including scalable engineering in astronomical data management, integrated Earth-science resources for SDG-13 decision making, and the coupling of citizen science and artificial intelligence (AI) techniques in biodiversity. We conclude with a forecast on the future development of research e-infrastructures and introduce the idea of the Global Open Science Cloud (GOSC). We hope this analysis can provide some insights into the future development of research e-infrastructures in support of open science.
The Polarimetric Radar Scattering Properties of Oriented Aggregates
Authors: Schrom Robert S. , Munchak S. Joseph , Adams Ian S. 
Published: February 2023

Abstract
The scattering properties of aggregates are studied herein. Early aggregates (<7 monomers) of branched planar crystals and mature aggregates (up to 100 monomers) of columns are randomly generated with varying assumptions about the monomer attachment processes and the orientation behavior during collection. The resulting physical properties of the aggregates correspond well with prior in situ and retrieved sizes and shapes. Assumed azimuthally uniform orientations during collection and monomer pivoting upon attachment resulted in flatter and denser aggregates. The column aggregates had lower density and more spherical shapes than the branched planar crystal aggregates. The scattering properties were calculated using the discrete dipole approximation for a set of orientation angles and transformed to spectral coefficients representing modes of orientation angle variability. The zeroth- and second-order coefficients dominate this variability, with the zeroth-order coefficients representing the scattering properties for randomly oriented particles. The second-order coefficients for backscatter showed differences between horizontal and vertical polarization increasing with density, and these coefficients for specific differential phase increase with both mass and density. Similarly, coefficients for the copolar covariance decreased with density. Rapid changes in the contributions to the radar moments from the second-order coefficients from low to moderate density were observed, likely due to the increasing presence of horizontally aligned monomers in the aggregate structure. Differences in how differential reflectivity and correlation coefficient evolve with the orientation distribution parameters suggest that these measurements, along with specific differential phase and reflectivity, provide complementary information about aggregate sizes, shapes, and orientation distributions.
Dyadic Association Between New Parents' Mindfulness and Relationship Satisfaction: Mediating Role of Perceived Stress
Authors: Morin Laurence , Laurin Julie C. , Doucerain Marina , Grégoire Simon 
Published: February 2023

The transition to parenthood is marked by increased potential stressors and relationship satisfaction declines among new parents. Recently, it has been suggested that people with greater mindfulness perceived their environment as less stressful during difficult times in life, which in turn, is associated with greater relationship satisfaction. Accordingly, this dyadic diary study evaluated if perceived stress explains the link between new parents' mindfulness and relationship satisfaction. A total of 78 new parent couples ( N = 156 participants; M = 6 months postpartum) provided ecologically valid perceived stress and relationship satisfaction data by responding to a questionnaire on their smartphones, between 7 p.m. and midnight, for 14 consecutive days. Data were analyzed using Actor-Partner Interdependence Mediation Model (APIMeM). Results revealed that parents with higher mindfulness reported lower perceived stress, which in turn was associated with them reporting higher relationship satisfaction. In addition, one’s mindfulness was directly positively associated with their partner’s relationship satisfaction. Lastly, when all partner effects between mindfulness, perceived stress and relationship satisfaction were tested together without defining specific partner paths, one’s mindfulness was positively associated with their partners’ relationship satisfaction. Our findings extend current knowledge on the dyadic association between mindfulness and relationship satisfaction during the transition to parenthood by highlighting perceived stress as a key variable underlying this relationship.
Time course changes in insulin sensitivity during cardiac surgery: A retrospective study on intraoperative glycemic management using an artificial pancreas
Authors: Uzawa Masashi , Koda Kenichiro , Kimura Haruka , Kimura Rie , Ito Yuya , Saito Aya , Motomura Noboru , Kitamura Takayuki 
Published: February 2023

Introduction Glycemic control is essential for improving the prognosis of cardiac surgery, although precise recommendations have not yet been established. Under a constant blood glucose level, the insulin infusion rate correlates with insulin resistance during glycemic control using an artificial pancreas (AP). We conducted this retrospective study to elucidate changes in intraoperative insulin sensitivity as a first step to creating glycemic control guidelines. Methods Fifty-five cardiac surgery patients at our hospital who underwent intraoperative glycemic control using an AP were enrolled. Twenty-three patients undergoing surgical procedures requiring cardiac arrest under hypothermic cardiopulmonary bypass (CPB) with minimum rectal temperatures lower than 32°C, 13 patients undergoing surgical procedures requiring cardiac arrest under hypothermic CPB with minimum rectal temperatures of 32°C, eight patients undergoing on-pump beating coronary artery bypass grafting and 11 patients undergoing off-pump coronary artery bypass were assigned to groups A, B, C and D, respectively. We analyzed the time course of changes in the data derived from glycemic control using the AP. Results Significant time course changes were observed in groups A and B, but not in groups C and D. Insulin resistance was induced after the start of hypothermic CPB in groups A and B, and the induced change was not resolved by the rewarming procedure, remaining sustained until the end of surgery. Conclusions Hypothermia is the predominant factor of the induced insulin resistance during cardiac surgery. Thus, careful glycemic management during hypothermic CPB is important. Prospective clinical studies are required to confirm the findings of this study.
Knee anatomic geometry accurately predicts risk of anterior cruciate ligament rupture
Authors: Hasoon Jahfer , Al-Dadah Oday 
Published: February 2023

Background Certain anatomical characteristics of the knee have potential relationships with the risk of anterior cruciate ligament (ACL) rupture. There remains a need for stronger evidence using arthroscopy as well as radiological imaging to accurately clarify these relationships. Purpose To compare the anatomic geometry of the knee joint between patients with and without ACL ruptures. Material and Methods Case-controlled study of patients with arthroscopically confirmed ACL ruptures (ACL group) compared to patients with arthroscopically confirmed normal ACLs (control group). Magnetic resonance imaging scans were assessed for a total of 14 quantitative radiological variables including medial and lateral tibial slope angles (bone and cartilage measurements), meniscal height, femoral width, intercondylar notch width and tibial depth. Results A total of 105 patients were included in the study, 55 in the ACL group and 50 in the control group. There was a significant difference ( P < 0.05) of most of the radiological measurements between the two groups. There was also a significant difference ( P < 0.05) when comparing the variables between sexes. Multiple logistic regression analysis produced a mathematical model utilizing all the radiological measurements with 92.6% classification accuracy in predicating an ACL rupture with the medial tibial slope angle being the strongest predicator variable (odds ratio = 8.97, P = 0.011). Conclusion Greater postero-inferior directed slope measurements of bone and cartilage in both the lateral and medial compartments with a narrower intercondylar notch width increase the risk of ACL rupture. Mathematical modelling can accurately predict the risk of ACL rupture.
Inhibition of DNA methylation attenuates lung ischemia–reperfusion injury after lung transplantation
Authors: Liu Ming-yuan , Ju Ying-nan , Jia Bao-wei , Sun Xi-kun , Qiu Lin , Liu Heng-yu , Xu Guang-xiao , Tai Qi-hang , Tan Jing , Gao Wei 
Published: February 2023

Objective DNA methylation plays an important role in inflammation and oxidative stress. This study aimed to investigate the effect of inhibiting DNA methylation on lung ischemia–reperfusion injury (LIRI). Methods We adopted a completely random design for our study. Thirty-two rats were randomized into the sham, LIRI, azathioprine (AZA), and pluripotin (SC1) groups. The rats in the LIRI, AZA, and SC1 groups received left lung transplantation and intravenous injection of saline, AZA, and SC1, respectively. After 24 hours of reperfusion, histological injury, the arterial oxygen partial pressure to fractional inspired oxygen ratio, the wet/dry weight ratio, protein and cytokine concentrations in lung tissue, and DNA methylation in lung tissue were evaluated. The pulmonary endothelium that underwent hypoxemia and reoxygenation was treated with AZA or SC1. Endothelial apoptosis, chemokines, reactive oxygen species, nuclear factor-κB, and apoptotic proteins in the endothelium were studied. Results Inhibition of DNA methylation by AZA attenuated lung injury, inflammation, and the oxidative stress response, but SC1 aggravated LIRI injury. AZA significantly improved endothelial function, suppressed apoptosis and necrosis, reduced chemokines, and inhibited nuclear factor-κB. Conclusions Inhibition of DNA methylation ameliorates LIRI and apoptosis and improves pulmonary function via the regulation of inflammation and oxidative stress.
Correlation between trans-perineal ultra-sonography, urodynamic study and physical examination findings in female patients with stress urinary incontinence: Single center experience
Authors: Mahmoudnejad Nastaran , Abrishami Alireza , Sharifiaghdas Farzaneh , Guitynavard Fateme , Zadmehr Alireza , Ansari Roya , Borumandnia Nasrin 
Published: February 2023

Background: To evaluate the efficacy of Trans-perineal ultrasonography (TPUS) in assessment of stress urinary incontinence (SUI) and its correlation with urodynamic study (UDS) and physical examination in women with SUI. Methods: The study enrolled a total of 91 females including 66 women with SUI and 25 women with no history of urinary incontinence as control group. The α and β angles (anterior urethral and posterior urethro-vesical angle respectively) were recorded both at rest and at straining, using TPUS. The differences between these angles at rest and during the straining were considered as the rotational angles (Rα and Rβ). Urethral length and caliber, bladder neck funneling, and pubo-urethral distance were measured as well. Results: The mean (SD) α angle at rest of the SUI group was 49.0 (±14.3)°, which was higher than the same parameter in the control group: 47.6 (±9.7)°. Similarly, the α angle at straining was significantly higher in the SUI group versus the control group, 61.0 (±15.4)° versus 55.8 (±15.8)°. The mean (SD) β angle in the SUI group at rest was 124.6 (±28.5)°, which was significantly higher than that of the control group at 114.0 (±22.5)°. The mean (SD) β angle at straining was also higher in the SUI group versus the control group: 151.8 (±90.6) versus 136.0 (±27)°. Moreover, higher Rα and Rβ angels were documented in the SUI group. Conclusion: Our data suggest that TPUS can be considered as a non-invasive, easily conducted, and accurate modality in early diagnosis of female SUI. It may reduce the need for performing relatively invasive UDS. However, the role of TPUS in assessment of SUI severity remains to be studied probably with a larger sample size.
Thulium laser enucleation of bladder tumour (Thulebt): Changing paradigm in the management of nonmuscle invasive urinary bladder carcinoma
Authors: Choudhury Sunirmal , Kamble Vaibhav , Jana Debarshi , Pal Dilip Kumar 
Published: February 2023

Objectives: To analyse the safety and eﬃcacy of Thulium laser en bloc enucleation of bladder tumour (ThuLEBT) in comparison to transurethral resection of bladder tumour (TURBT) for treatment of non-muscle invasive bladder cancer (NMIBC). Methods: Prospective observational study involving 30 patients in each group of ThuLEBT and TURBT admitted in tertiary care centre from 1st January 2021 to December 2021. Results: Signiﬁcant difference was found in terms of less operative time ( p-0.01468), less intraoperative blood loss, a lower incidence of obturator nerve reﬂex ( p-0.00006), bladder perforation ( p-0.0455) and bladder irrigation ( p-0.0027), better acquisition of detrusor muscle ( p-0.0466), less recurrence rate ( p-0.0455) in favour of ThuLEBT over TURBT group. The analysis also demonstrated faster postoperative recovery in terms of the duration of catheterisation, bladder irrigation and hospitalisation time in ThuLEBT group. Conclusions: ThuLEBT is an eﬃcient and safe treatment for non-muscle invasive bladder cancer and it can be a better alternative choice in place of TURBT.
Amelioration of AlCl3-induced Memory Loss in the Rats by an Aqueous Extract of Guduchi, a Medhya Rasayana
Authors: Jamadagni Shrirang B. , Ghadge Pooja M. , Tambe Mukul S. , Srinivasan Marimuthu , Prasad Goli Penchala , Jamadagni Pallavi S. , Prasad Shyam Baboo , Pawar Sharad D. , Gurav Arun M. , Gaidhani Sudesh N. , Kumar Y. R. Sanjay , Srikanth Narayanam 
Published: February 2023

Background In ayurvedic practice, the Guduchi ( Tinospora cordifolia (Willd.) Miers) stem is used as a Medhya drug for its beneficial effects on memory improvement. Objectives The current study was planned to explore the Medhya properties of the Guduchi stem extract by observing its ameliorating effect on AlCl3-induced neurotoxicity in rats that acted as a chronic model of memory loss. Materials and Methods The aqueous extract of the Guduchi stem was prepared per the Ayurvedic Pharmacopoeia of India and administered to the AlCl3-treated Wistar rats for 42 days. The biochemical assessment of the brain tissues of the treated animals was done by the acetylcholinesterase (AChE) inhibition assay, protein expression, and oxidative stress assays, namely lipid peroxidation, reduced glutathione, superoxide dismutase, and catalase assay. The neurobehavioral assessment was done using the elevated plus maze (EPM) test. Results The EPM test revealed that treatment with Guduchi extract showed marked improvement of memory status in rats along with reduced oxidative stress, and a marked modulation of the AChE inhibition and expression of AChE tubulin proteins. Conclusion The results substantiate the Medhya properties of the Guduchi. Detailed investigations are required to be carried out to explore the precise mechanism of the neuroprotective action of the Guduchi stem extract against the AlCl3-induced neurotoxicity in rats.
Modulation of Indoleamine 2,3-Dioxygenase 1 During Inflammatory Bowel Disease Activity in Humans and Mice
Authors: Proietti Elisa , Pauwels Renske W.M. , de Vries Annemarie C. , Orecchini Elena , Volpi Claudia , Orabona Ciriana , Peppelenbosch Maikel P. , Fuhler Gwenny M. , Mondanelli Giada 
Published: February 2023

Background and Aims: Indoleamine 2,3 dioxygenase-1 (IDO1), a key enzyme in tryptophan metabolism, is strongly up-regulated both in human inflammatory bowel disease (IBD) and animal models of colitis, however its role in the pathogenesis is still controversial. In this study, we investigated IDO1 expression and activity in a mouse model of DSS-induced chronic colitis as well as in colon biopsies and sera from IBD patients. Methods: Chronic colitis was induced in mice through the oral administration of dextran sodium sulfate (DSS), and IDO1 activity was induced by i.p. treatment with N-acetyl serotonin (NAS). IDO1 expression and catalytic activity (measured as Kyn/Trp ratio) was evaluated in sera and tissue samples collected from mice and 93 IBD patients under immunotherapy with Vedolizumab (VDZ) or Ustekinumab (UST). Results: Strong up-regulation of IDO1 was found in colons of mice with acute colitis, which follows disease activity. Enhanced IDO1 activity by NAS treatment protects the intestinal mucosa during the recovery phase of chronic colitis. In IBD patients, IDO1 expression and activity correlate with the severity of mucosal inflammation with inflamed regions showing higher IDO1 expression compared to non-inflamed regions within the same patient. Endoscopic response to VDZ/UST treatment is associated with decreased expression of IDO1. Conclusions: This is the first study demonstrating immunomodulatory activity of IDO1 in a chronic mouse model of DSS-induced colitis. As its expression and catalytic activity correlate with the grade of mucosal inflammation and treatment response, IDO1 could represent a promising biomarker for disease severity and treatment monitoring in IBD.