bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and clinical correlations of olfactory recess dilatation in MRI studies of the feline brain
Authors: McGregor Ombeline , Genain Marie‐Aude , Williams Timothy Lee , Alves Lisa 
Published: February 2023

AbstractThe ability to differentiate clinical ventriculomegaly from incidental ventricular enlargement remains a challenge in veterinary radiology. Dilatation of one or both olfactory lobe recesses is occasionally seen on MRI of the brain in otherwise normal cats. The purpose of this study was therefore to determine the prevalence of this finding within a population of neurologically normal and neurologically abnormal cats, and to investigate associations with signalment, clinical and neurological examination findings, and MRI features. An observational retrospective cohort study was performed, and archived records were searched for cats that had undergone MRI of the head, including the olfactory lobes. Medical data and MRI parameters were recorded. One hundred fifty‐one cats were included, with olfactory recess dilatation present in 56 cats. In 16 neurologically normal cats, olfactory recess dilatation was the only MRI finding. Olfactory recess dilatation was not associated with age, sex, breed, or with the presence of nasal disease. A significant association was found between generalized ventriculomegaly (P = 0.001) and the presence of CSF abnormalities (P = 0.036). Eleven percent of our cohort (16/151) demonstrated olfactory recess dilatation in the absence of other neurological or structural intracranial disease, suggesting that this may be seen as a normal variation in some cats.
A Novel Analytical Explicit Method to Calculate Formed Wheel and Tooth Flank of Involute Gears in Profile Grinding Process
Authors: Guo Qiang , Zhao Weisen , Shu Changlin , Lee Yuan-Shin , Sun Yuwen , Ren Lei , Song Mingzhe 
Published: February 2023

AbstractGear drive is a common and efficient way to transfer power and motion. To ensure the machining accuracy of gears, the tooth flanks are formed by profile grinding technology in some cases. In the profile grinding process, the calculation of wheels using the information of gears named as the forward-calculation process and obtaining gears based on wheels (the backward-calculation process) traditionally adopt numerical ways. It is always time consuming and large code quantity. To conquer these drawbacks, this article presents an analytical method using the envelope theory to compute the contacting curves that are the basis of getting tooth flanks or wheels in the forward- or the backward-calculation process. For the forward-calculation process, the tooth flank is expressed in the form of an extended straight-line surface that can be taken as the generating line moving along the helix curve. The normal vector for an arbitrary point on the generating line is the same. By using this characteristic, the contacting curve can be explicitly gained as the function of only one parameter. Similarly, in the backward-calculation process, the formed wheel is expressed by a cross section rotating about its axis. For this type of surface, the guide curve is a circle, and the normal vectors of points on the guideline insect with the axis at the same point. Taking advantage of this principle, the contacting curve can be analytically expressed by only one unknown parameter. To verify the validity of the proposed method, some examples and comparative experiments are performed. The results show that the presented method is correct. When compared with the classical numerical way, the time span for the proposed method is 15 times less than that for the numerical way. When compared with the practical grinding wheel and the practical gear, the maximum errors are 0.18 mm and 0.0099 mm, respectively. The proposed method can be served as one of the universal ways to generate formed wheels or involute gears in the profile grinding process.
Routine follow-up may not be needed for people undergoing joint replacement surgery
Authors: Saul Helen , Cassidy Samantha , Deeney Brendan , Kwint Jemma , Conaghan Philip 
Published: February 2023

The studyKingsbury SR, Smith LK, Czoski Murray CJ, et al. Safety of disinvestment in mid- to late-term follow-up post primary hip and knee replacement: the UK SAFE evidence synthesis and recommendations.Health Soc Care Deliv Res2022;10. doi:10.3310/KODQ0769.To read the full NIHR Alert, go to:https://evidence.nihr.ac.uk/alert/joint-replacement-many-people-can-safely-wait-10-years-for-follow-up/
Assessing the impact of COVID-19 pandemic on the health of residents and the healthcare system in Alberta, Canada: an observational study—The Alberta POST-COVID Follow-up Study
Authors: Chen Xueyi , Bakal Jeffrey , Whitten Tara , Waldie Barbara , Ho Chester , Wright Paul , Hassam Shahin , Norris Colleen 
Published: February 2023

IntroductionVery little is known about how the COVID-19 pandemic has affected the health of residents and the healthcare system in Alberta, Canada. The purpose of this study is to establish an observational study to characterise the health of residents in Alberta, Canada, over time, covering a population that tested negative or positive for COVID-19 during the pandemic. The primary outcome is to characterise ‘long COVID-19’ and the health status of residents during the COVID-19 pandemic. Secondary outcomes include the estimation of the risk of and risk factors associated with adverse health outcomes and healthcare utilisation and burdens.Methods and analysisThis is a population-level provincial observational study which will follow-up with Alberta residents who underwent testing for COVID-19 and completed surveys adapted from the ISARIC COVID-19 long-term follow-up survey. The survey data will be linked with medical records. Statistical analyses will be carried out to characterise ‘long COVID-19’ and the health status of residents during the pandemic. The outcomes of this study will inform strategies for primary care and rehabilitation services to prevent chronic consequences; contribute to healthcare management, interventional studies, rehabilitation and health management to reduce overall morbidity and improve long-term outcomes of COVID-19 and the COVID-19 pandemic and potentially guide a self-evaluation of a remote monitoring system to manage individuals’ health.Ethics and disseminationThis study was reviewed and approved by the University of Alberta ethics committee (Study ID: Pro00112053 & Pro00113039) on 13 August 2021 and adheres to the Alberta Health Services research information management policy. Study results will be used to manage clinical care, published in peer-reviewed journals and presented at local, national and international conferences.Protocol version6 June 2022EuroQol ID161 015.
Potential problems and solutions of opioid-based treatment in neonatal opioid withdrawal syndrome (NOWS): a scoping review protocol
Authors: Mills-Huffnagle Sara , Nyland Jennifer E 
Published: February 2023

IntroductionRates of neonatal opioid withdrawal syndrome (NOWS) have paralleled the rise of opioid use during pregnancy. While short-term phenotypic symptoms of NOWS are well defined, molecular implications and long-term effects are not well understood. Preferred and first-line of treatment for NOWS includes non-pharmacological interventions; however, more than half of the NOWS neonates will need pharmacologics, with opioids as the primary pharmacological treatment. While effective at reducing symptoms, treating NOWS with opioids is paradoxical given that molecular and long-term developmental consequences with such exposure are unknown. There is a pressing need for a synthesis of current and potential/ novel treatment options for NOWS.Methods and analysisFollowing a published framework, a scoping review will be conducted to evaluate NOWS treatment, including established treatment methods and novel methods that may warrant future research and consideration. Using broad search terms, as well as Medical Subject Headings terms, a comprehensive search of PubMed, Cochrane Library, Google Scholar, CINAHL, Web of Science and Scopus, as well as references of selected literature, will take place, followed by a screening procedure to identify included and excluded articles. Included studies must address NOWS treatment, or opioid withdrawal treatment of any age group, that may or may not have been tested in preclinical or clinical models. Results will summarise the current pharmacological and non-pharmacological treatment methods for NOWS, as well as potential novel treatments with a specific interest in non-opioid pharmacological interventions.Ethics and disseminationThis scoping review aims to broadly search preclinical and clinical literature as it relates to treatment of NOWS, including potential novel treatments with a specific interest in non-opioid pharmacological interventions. Given that this study does not directly involve human subjects or animal subjects research, Institutional Review Board (IRB) or Institutional Animal Care and Use Committee (IACUC) approval is not required. Results of this scoping review will be disseminated at conferences and submitted for publication in a peer-reviewed journal.
The effect of configurational complexity in hetero-polymers on the coil-globule phase transition
Authors: Tafuri Fabrizio , Chiariello Andrea M. 
Published: February 2023

AbstractThe coil-globule transition of hetero-polymer chains is studied here. By means of extensive Molecular Dynamics simulations, we show that the transition is directly linked to the complexity of the chain, which depends on the number of chemical species defined in the environment and the location of the binding sites along the polymer. In addition, when the number of species increases, we find that the distribution of binding sites plays an important role in triggering the transition, beyond the standard control parameters of the polymer model, i.e. binders concentration and binding affinity. Overall, our results show that by increasing the system complexity new organizational layers emerge, thus allowing a more structured control on the polymer thermodynamic state. This can be potentially applied to the study of chromatin architecture, as such polymer models have been broadly used to understand the molecular mechanisms of genome folding.
A functional gene module identification algorithm in gene expression data based on genetic algorithm and gene ontology
Authors: Zhang Yan , Shi Weiyu , Sun Yeqing 
Published: February 2023

AbstractSince genes do not function individually, the gene module is considered an important tool for interpreting gene expression profiles. In order to consider both functional similarity and expression similarity in module identification, GMIGAGO, a functional Gene Module Identification algorithm based on Genetic Algorithm and Gene Ontology, was proposed in this work. GMIGAGO is an overlapping gene module identification algorithm, which mainly includes two stages: In the first stage (initial identification of gene modules), Improved Partitioning Around Medoids Based on Genetic Algorithm (PAM-GA) is used for the initial clustering on gene expression profiling, and traditional gene co-expression modules can be obtained. Only similarity of expression levels is considered at this stage. In the second stage (optimization of functional similarity within gene modules), Genetic Algorithm for Functional Similarity Optimization (FSO-GA) is used to optimize gene modules based on gene ontology, and functional similarity within gene modules can be improved. Without loss of generality, we compared GMIGAGO with state-of-the-art gene module identification methods on six gene expression datasets, and GMIGAGO identified the gene modules with the highest functional similarity (much higher than state-of-the-art algorithms). GMIGAGO was applied in BRCA, THCA, HNSC, COVID-19, Stem, and Radiation datasets, and it identified some interesting modules which performed important biological functions. The hub genes in these modules could be used as potential targets for diseases or radiation protection. In summary, GMIGAGO has excellent performance in mining molecular mechanisms, and it can also identify potential biomarkers for individual precision therapy.
Transcriptome sequencing and gene expression analysis revealed early ovule abortion of Paeonia ludlowii
Authors: Chen Ting-qiao , Sun Yue , Yuan Tao 
Published: February 2023

Abstract
Background
Paeonia ludlowii (Stern & G. Taylor D.Y. Hong) belongs to the peony group of the genus Paeonia in the Paeoniaceae family and is now classified as a “critically endangered species” in China. Reproduction is important for this species, and its low fruiting rate has become a critical factor limiting both the expansion of its wild population and its domestic cultivation.

Results
In this study, we investigated possible causes of the low fruiting rate and ovule abortion in Paeonia ludlowii. We clarified the characteristics of ovule abortion and the specific time of abortion in Paeonia ludlowii, and used transcriptome sequencing to investigate the mechanism of abortion of ovules in Paeonia ludlowii.

Conclusions
In this paper, the ovule abortion characteristics of Paeonia ludlowii were systematically studied for the first time and provide a theoretical basis for the optimal breeding and future cultivation of Paeonia ludlowii.
Counting what counts: a systematic scoping review of instruments used in primary healthcare services to measure the wellbeing of Indigenous children and youth
Authors: Saunders Vicki , McCalman Janya , Tsey Sena , Askew Deborah , Campbell Sandy , Jongen Crystal , Angelo Candace , Spurling Geoff , Cadet-James Yvonne 
Published: February 2023

Abstract
Background
Primary healthcare services have principal responsibility for providing child and youth wellbeing and mental health services, but have lacked appropriate measurement instruments to assess the wellbeing of Indigenous children and youth or to evaluate the effectiveness of programs and services designed to meet their needs. This review assesses the availability and characteristics of measurement instruments that have been applied in primary healthcare services in Canada, Australia, New Zealand and the United States (CANZUS countries) to assess the wellbeing of Indigenous children and youth.

Methods
Fifteen databases and 12 websites were searched in December 2017 and again in October 2021. Pre-defined search terms pertained to Indigenous children and youth, CANZUS country names, and wellbeing or mental health measures. PRISMA guidelines were followed, with eligibility criteria guiding screening of titles and abstracts, and selected full-text papers. Results are presented based on the characteristics of documented measurement instruments assessed according to five desirability criteria: development for Indigenous youth populations, adherence to relational strength-based constructs, administration by child and or youth self-report, reliability and validity, and usefulness for identifying wellbeing or risk levels.

Results
Twenty-one publications were found that described the development and or use by primary healthcare services of 14 measurement instruments, employed across 30 applications. Four of the 14 measurement instruments were developed specifically for Indigenous youth populations, four focused solely on strength-based wellbeing concepts but none included all Indigenous wellbeing domains.

Conclusion
There is a diversity of measurement instruments available, but few fit our desirability criteria. Although it is possible that we missed relevant papers and reports, this review clearly supports the need for further research to develop, refine or adapt instruments cross-culturally to measure the wellbeing of Indigenous children and youth.
Delivering diabetes shared medical appointments in primary care: early and mid-program adaptations and implications for successful implementation
Authors: Nederveld Andrea , Phimphasone-Brady Phoutdavone , Gurfinkel Dennis , Waxmonsky Jeanette A. , Kwan Bethany M. , Holtrop Jodi Summers 
Published: February 2023

Abstract
Background
Self-management is essential for good outcomes in type 2 diabetes and patients often benefit from self-management education. Shared medical appointments (SMAs) can increase self-efficacy for self management but are difficult for some primary care practices to implement. Understanding how practices adapt processes and delivery of SMAs for patients with type 2 diabetes may provide helpful strategies for other practices interested in implementing SMAs.

Methods
The Invested in Diabetes study was a pragmatic cluster-randomized, comparative effectiveness trial designed to compare two different models of diabetes SMAs delivered in primary care. We used a multi-method approach guided by the FRAME to assess practices’ experience with implementation, including any planned and unplanned adaptations. Data sources included interviews, practice observations and field notes from practice facilitator check-ins.

Results
Several findings were identified from the data: 1) Modifications and adaptations are common in implementation of SMAs, 2) while most adaptations were fidelity-consistent supporting the core components of the intervention conditions as designed, some were not, 3) Adaptations were perceived to be necessary to help SMAs meet patient and practice needs and overcome implementation challenges, and 4) Content changes in the sessions were often planned and enacted to better address the contextual circumstances such as patient needs and culture.

Discussion
Implementing SMAs in primary care can be challenging and adaptations of both implementation processes and content and delivery of SMAS for patients with type 2 diabetes were common in the Invested in Diabetes study. Recognizing the need for adaptations based on practice context prior to implementation may help improve fit and success with SMAs, but care needs to be given to ensure that adaptations do not weaken the impact of the intervention. Practices may be able to assess what might need to adapted for them to be successful prior to implementation but likely will continue to adapt after implementation.

Conclusion
Adaptations were common in the Invested in Diabetes study. Practices may benefit from understanding common challenges in implementing SMAs and adapting processes and delivery based on their own context.

Trial registration
This trial is registered on clinicaltrials.gov under Trial number NCT03590041, posted 18/07/2018.
Influence of chronic obstructive pulmonary disease on long-term hospitalization and mortality in patients with heart failure with reduced ejection fraction
Authors: Lin Chiung-Hung , Yeh Jih-Kai , Lin Ting-Yu , Lo Yu-Lun , Chang Bo-Jui , Ju Jia-Shiuan , Chiu Tzu-Hsuan , Tung Pi-Hung , Huang Yun-Ju , Lin Shu-Min 
Published: February 2023

Abstract
Background
Heart failure with reduced ejection fraction (HFrEF) can coexist with chronic obstructive pulmonary disease (COPD), which complicates the clinical situation and worsens quality of life. The study used standard diagnostic criteria for detecting COPD in hospitalized HFrEF patients and to survey the influence of other comorbidities and medications on the long-term outcomes of HFrEF + COPD patients.

Methods
We retrospectively recruited patients hospitalized due to HFrEF in a tertiary medical center and examined and followed up clinical outcomes, including length of hospital stay, mortality, and readmission episodes, for a 5-year period. Risk factors for mortality were analyzed using multivariate analysis.

Results
Of the 118 hospitalized HFrEF study participants, 68 had concurrent COPD whereas 50 did not. There was a significant increase in the male predominance, smoking history, higher hemoglobin level and increased length of hospital stay in the HF + COPD group than in the HF-only group. Lower left ventricular ejection fraction was found in the HF and COPD comorbidity group. In multivariate analysis, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) use independently associated with a beneficial effect on survival in HF patients with COPD. Oral corticosteroid uses and stroke as a comorbidity were independently associated with a shorter time to the first readmission episode.

Conclusion
In HFrEF patients, COPD was associated with a prolonged length of hospital stay. ACEI/ARB use might relate to a beneficial effect on survival in HF patients with COPD. The use of maintenance oral corticosteroid in patients with both HF and COPD should be crucially evaluated to determine the clinical benefit and disadvantages.
The effect of screen time on the presentation and treatment of primary monosymptomatic nocturnal enuresis
Authors: Demirbas Arif , Gercek Hacer Gizem 
Published: February 2023

Abstract
Background
We aimed to investigate if there was any relationship between screen time (ST) and the severity of primary monosymptomatic nocturnal enuresis (PMNE) and treatment success.

Methods
This study was conducted in urology and child and adolescent phsychiatry clinic in Afyonkarahisar Health Sciences University Hospital. After diagnosis patients were seperated by the ST for exploring causation. Group 1 > 120, Group 2 < 120 (min/day). For the the treatment response, patients were grouped again. Group 3 patients were administered 120 mcg Desmopressin Melt (DeM) and were requested < 60 min ST. Patients in Group 4 were given 120 mcg DeM solely.

Results
The first stage of the study included 71 patients. The ages of the patients ranged from 6 to 13. Group 1 comprised 47 patients, 26 males and 21 females. Group 2 comprised 24 patients,11 males and 13 famales. Median age was 7 years in both groups. The groups were similar in respect of age and gender (p = 0.670, p = 0.449, respectively). A significant relationship was determined between ST and PMNE severity. Severe symptoms were seen at the rate of 42.6% in the Group 1, and at 16.7% in the Group 2 (p = 0.033). 44 patients completed the second stage of the study. Group 3 comprised 21 patients, 11 males and 10 females. Group 4 comprised 23 patients,11 males and 12 famales. Median age was 7 years in both groups. The groups were similar in respect of age and gender (p = 0.708, p = 0.765, respectively). Response to treatment was determined as full response in 70% (14/20) in Group 3 and in 31% (5/16) in Group 4 (p = 0.021). Failure was determined in 5% (1/21) in Group 3 and in 30% (7/23) in Group 4 (p = 0.048). Recurrence was determined at a lower rate in Group 3 where ST was restricted (7% vs. 60%, p = 0.037).

Conclusion
High screen exposure may be a factor for PMNE aetiology. And also reducing ST to a normal range can be an easy and beneficial method for treatment of PMNE.
Trial Registration ISRCTN15760867(www.isrctn.com). Date of registration: 23/05/2022. This trial was registered retrospectively.