bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of disease progression during treatment with Osimertinib in patients with EGFR T790M‐positive non‐small cell lung cancer
Authors: Kim Hye Sook , Lim Kun Young , Lee Soo‐Hyun , Kim Hyae Young , Lee Youngjoo , Han Ji‐Youn 
Published: April 2023

AbstractBackgroundPatterns of treatment failure and subsequent treatment in non‐small cell lung cancer (NSCLC) patients treated with osimertinib are scarcely known. We analyzed the disease progression during osimertinib treatment to identify potential treatment strategies.MethodsWe identified advanced NSCLC patients who commenced osimertinib treatment after progression on previous epidermal growth factor receptor (EGFR)‐tyrosine‐kinase inhibitor (TKI) from June 2014 to November 2018 from electronic records. Patients' tumor characteristics, efficacy outcomes, affected organs from radiology studies, and treatment modalities before and after osimertinib were analyzed.ResultsEighty‐four patients were included. At osimertinib initiation, bone (50.0%) and brain (41.9%) were the commonest single metastatic sites, whereas thoracic involvement (73.3%) was more frequent than bone (27.4%) or brain (20.2%) metastasis during disease progression on osimertinib. Oligo‐progressive disease (PD) and central nervous system (CNS)‐sanctuary PD were observed in 15 (17.9%) and 3 (3.6%) patients, respectively. Most patients without brain metastasis (BM) at osimertinib initiation remained BM‐free (46/49, 93.9%), and 60% of patients (21/35) with pre‐existing BM showed intracranial disease control despite extracranial PD. The resistance mechanisms to osimertinib were explored in 23 patients (27.4%), and T790M‐loss was observed in 14 patients (60.9%) who had worse survival outcomes than those without T790M‐loss (progression‐free survival, 5.4 vs. 16.5 months, p = 0.02; overall survival, not reached, p = 0.03).ConclusionPD during osimertinib treatment occurred preferentially in the thorax and pre‐existing sites. Extracranial PD prevailed over intracranial PD regardless of baseline BM and prior brain radiation. These results support osimertinib's intracranial efficacy and may guide treatment strategies for EGFR‐mutated NSCLC with BM.
Targeting exosomes enveloped EBV‐miR‐BART1‐5p‐antagomiRs for NPC therapy through both anti‐vasculogenic mimicry and anti‐angiogenesis
Authors: Wang Jianguo , Liu Yan , Zhang Yuanbin , Li Xiaoyang , Fang Min , Qian Dong 
Published: April 2023

AbstractBackgroundNasopharyngeal carcinoma (NPC) is a type of head and neck cancer with high incidence in China. The molecular mechanisms of vasculogenic mimicry (VM) and angiogenesis are not fully elucidated in NPC. More specially, it has seldomly been reported that Epstein–Barr virus‐encoded miRNA can regulate VM and angiogenesis in NPC. The aim of this study was to investigate the function and molecular mechanism of a targeting exosome system (iRGD‐exo‐antagomiR) against VM and angiogenesis in NPC, and to provide new approaches for improving the comprehensive treatment of NPC.MethodsExosomes were isolated by differential ultracentrifugation. Dynamic light scattering, transmission electron microscopy and western blotting were performed to characterize the exosomes. The 3D‐Culture assay, tube formation assay, chicken chorioallantoic membrane assay, Matrigel plug assay, mouse xenograft tumor modeling and immunohistochemical staining were applied to evaluate the anti‐VM and anti‐angiogenic effects of the targeting exosome system in vitro and in vivo. Western blot was performed to detect the changes of downstream regulated networks following interference and recovery of the target gene.ResultsIn vitro or in vivo treatment with iRGD‐tagged exosome containing antagomiR‐BART1‐5p specifically suppressed VM and angiogenesis in NPC. EBV‐miR‐BART1‐5p promoted VM and angiogenesis in vitro and in vivo by regulating VEGF, PI3K, Akt, mTOR and HIF1‐α in a Spry2‐dependent manner.ConclusionsOur findings demonstrated that targeting exosomes enveloped EBV‐miR‐BART1‐5p‐antagomiRs in a Spry2‐dependent manner for NPC therapy through both anti‐VM and anti‐angiogenesis in vitro and in vivo.
The variability of client, therapist and clinic in psychotherapy outcomes: A three‐level hierarchical model
Authors: Mahon Daryl , Minami Takuya , Brown (G.S.) Jeb 
Published: April 2023

AbstractThis article investigates the percentage of variance in psychotherapy outcomes explained by the case‐mix variables for individual cases, by the therapist (therapist effects), and what additional variance is explained by the clinic with which the therapist is affiliated. While there has been substantial recent research regarding therapist effects, very little has been published regarding clinic‐level effects after controlling for therapist effects. The study utilised the largest sample reported to date, using data from 28 clinics with a minimum of 2,000 cases in a clinical range of severity of symptoms with pre‐post change scores on an outcome questionnaire. Only cases treated by a therapist with at least 30 cases were included. These selection criteria resulted in a case count of 156,258 clients treated by 874 therapists located at 28 clinics. After controlling for differences in case mix using diagnosis and intake score (severity of symptoms), the resulting analyses indicated that 5.21% of the variance in treatment outcome was explained by the therapist, while another 1.13% of the variance was associated with the clinic. Findings are discussed with implications for practice and policy.
Combining Representation Learning and Active Learning for Applications in Process Manufacturing
Authors: Dathatri Ashwini Gonibedu , Strem Nika , Klöpper Benjamin 
Published: April 2023

AbstractMultivariate time series classification (TSC) is an important data‐driven modeling task in process industries. A common challenge of TSC in the process industry is the unavailability of labels. Active learning (AL) tackles this problem by incrementally obtaining as few labeled instances as possible by querying an oracle. From our initial experience of building an AL application we derive requirements on the machine learning approach in the context of such an interactive application. To meet the requirements, we combine AL with representation learning (RL): a model learns a latent space representation of unlabeled data, which is then used to train a classification model on the labeled data.
Electrochemical Performances of Nickel‐Rich Single‐Crystal LiNi0.83Co0.12Mn0.05O2 Cathode Material for Lithium‐Ion Batteries Synthesized by Tuning Li+/Ni2+ Mixing
Authors: Yang Zhuolin , Zhang Xinyu , Lu Shijie , Xiao Jianxiong , Wu Borong , Zhao Zhikun , Mu Daobin 
Published: April 2023

AbstractSingle‐crystal nickel‐rich materials are promising alternatives to polycrystalline cathodes owing to their excellent structure stability and cycle performance while the cathode material usually appears high cation mixing, which may have a negative effect on its electrochemical performance. The study presents the structural evolution of single‐crystal LiNi0.83Co0.12Mn0.05O2 in the temperature–composition space using temperature‐resolved in situ XRD and the cation mixing is tuned to improve electrochemical performances. The as‐synthesized single‐crystal sample shows high initial discharge specific capacity (195.5 mAh g−1 at 1 C), and excellent capacity retention (80.1 % after 400 cycles at 1 C), taking account of lower structure disorder (Ni2+ occupying Li sites is 1.56 %) and integrated grains with an average of 2–3 μm. In addition, the single‐crystal material also displays a superior rate capability of 159.1 mAh g−1 at the rate of 5 C. This excellent performance is attributed to the rapid Li+ transportation within the crystal structure with fewer Ni2+ cations in Li layer as well as intactly single grains. In sum, the regulation of Li+/Ni2+ mixing provides a feasible strategy for boosting single‐crystal nickel‐rich cathode material.
Trace Ionic Liquid‐Assisted Orientational Growth of Cu2O (110) Facets Promote CO2 Electroreduction to C2 Products
Authors: Wang Wenhang , Ning Hui , Fei Xiang , Wang Xiaoshan , Ma Zhengguang , Jiao Zhenmei , Wang Yani , Tsubaki Noritatsu , Wu Mingbo 
Published: April 2023

AbstractCu2O has great advantages for CO2 electroreduction to C2 products, of which the activity and selectivity are closely related to its crystal facets. In this work, density functional theory calculation indicated that the (110) facets of Cu2O had a lower energy barrier for the C−C coupling compared to the (100) and (111) facets. Therefore, Cu2O(110) facets were successfully synthesized with the assistance of trace amounts of the ionic liquid 1‐butyl‐3‐methylimidazolium ([Bmim]BF4) by a sample wet‐chemical method. A high faradaic efficiency of 71.1 % and a large current density of 265.1 mA cm−2 toward C2H4 and C2H5OH were achieved at −1.1 V (vs. reversible hydrogen electrode) in a flow cell. The in situ and electrochemical analysis indicated that it possessed the synergy effects of strong adsorption of *CO2 and *CO, large active area, and excellent conductivity. This study provided a new way to enhance the C2 selectivity of CO2 electroreduction on Cu2O by crystal structure engineering.
Novel comprehensive feedback theory—Part II: Unifying previous and new feedback models and further results
Authors: Pellegrini Bruno , Macucci Massimo , Marconcini Paolo 
Published: April 2023

SummaryThe objective of this Part II of the paper on a novel feedback approach is that of unifying all the previous general feedback models within a single framework and of obtaining new results. In order to pursue this goal, we exploit the multiple possibilities of implementation of the generic three‐terminal circuit (TTC) that has to be inserted in the cut of the feedback loop when the cut‐insertion theorem (CIT) is applied for the analysis of the network. We present models based on a direct opening of the feedback loop inside the TTC, TTC implementations (associated with circuital examples) that allow an arbitrary splitting of the signal flow between a part associated to the feedback loop and another due to a direct leakage path from input to output, and methods (with exemplifying networks) based on test signal injection that allow measuring the gain of the closed feedback loop. The asymptotic formula of the overall gain is generalized to any network. Finally, examples of application to a voltage‐feedback amplifier are reported to show, in particular, the values and the properties of the multiple possible feedback loop gains that can be defined for a given cut and also to compare our results with those available in the literature.
Rapid on‐site evaluation in percutaneous core needle biopsies of renal masses: Cytologic‐histologic concordance and diagnostic challenges
Authors: Hojat Seyed Amin , Ravish Nakul A. , Azabdaftari Gissou , Yang Zhongbo 
Published: April 2023

AbstractBackgroundImage‐guided fine needle aspirations (FNAs) and core needle biopsies (CNBs) play the critical role in diagnosis of renal lesions. Rapid on‐site evaluation (ROSE) can potentially increase the adequacy rate and improve diagnostic yield, while providing additional information for rapid clinical decisions. The aim of this study is to evaluate the diagnostic utility of ROSE in obtaining adequate tissue for diagnosis of renal lesions in our institution.MethodsWe retrospectively reviewed all percutaneous renal CNB cases with available ROSE interpretations for a 11‐year period. The ROSE interpretations and CNB diagnoses was compared and the concordance rate was calculated accordingly. The discrepant cases were re‐reviewed and the possible causes for discrepancy were analyzed.ResultsA total of 189 cases were identified. Definitive diagnoses were rendered in 164 (87%) cases on the final CNBs, including primary renal lesions in 151 cases and metastatic malignancies in 13 cases. At the time of ROSE, samples were deemed to be adequate in the majority of cases (83%). The calculated concordance rate between ROSE interpretations and CNB final diagnoses was 84.6%. Sampling issue and scant tumor cells were the main causes for the discordance between ROSE interpretations and CNB diagnoses.ConclusionOur study showed a relatively high‐concordance rate of 84.6% between ROSE interpretations and CNB final diagnoses, suggesting that ROSE is a valuable tool for procurement of adequate renal CNB samples for diagnosis.
Combining multiple markers significantly increases the sensitivity and precision of eDNA‐based single‐species analyses
Authors: Brys Rein , Halfmaerten David , Everts Teun , Van Driessche Charlotte , Neyrinck Sabrina 
Published: April 2023

AbstractThe analysis of environmental DNA (eDNA) is becoming integrated as an established biomonitoring tool, often characterized by detection limits exceeding those of conventional counterparts. However, further improving the sensitivity of these methods may be invaluable for the early detection of invasive species, or for locating remnant populations of endangered species, and the adequate quantification of their abundances. In this study, we provide empirical evidence showing that the implementation of multiple genetic markers targeting different loci is a surprisingly overlooked strategy to increase the sensitivity of single‐species detections and quantification of their abundance, particularly at the lower end of the species abundance range. We analyzed 45 natural eDNA samples obtained from a wide range of water bodies in Belgium, in which either the invasive American bullfrog (Lithobates catesbeianus) or the rare European weather loach (Misgurnus fossilis) occurred under variable abundances, and compared detection success and precision of quantification of simplex (single locus) versus multiplex (multilocus) droplet digital PCR (ddPCR) analyses. Multiplexing different primer/probe assays targeting independent loci resulted in a significantly enhanced detection probability compared to the simplex analyses, gaining a twofold reduction in the limit of detection (LOD). Also the precision of eDNA quantification significantly improved in multiplex reactions, especially in low concentration samples. This was reflected in a significant reduction in the coefficient of variation (CV) among technical replicates, resulting in an associated decrease of the limit of quantification (LOQ). We conclude that the use of multiple markers can significantly improve the analytical sensitivity of eDNA‐based single‐species detections and precision of absolute abundance quantifications.
High accuracy and efficiency calculation model for predicting the reduction of residual stress on large pressure vessels by ultrasonic impact surface treatment
Authors: Luo Yun , Jiang Wenchun , Zeng Qiang 
Published: April 2023

AbstractUltrasonic impact treatment (UIT) is a new surface strengthening method to reduce the residual stresses on large pressure vessels induced by surface and repair welding. An accurate and high efficiency calculation model is the key to accurately predicting the full‐field residual stresses on large pressure vessels under the UIT process. In this article, a full‐coverage impacting model is proposed to simulate the impacting process of the UIT pin. The effects of UIT on the residual stresses on repair and surface welded pressure vessels were investigated by explicit dynamic simulation. Experiments were also performed to verify the prediction results. Results show that the proposed full coverage impacting model can greatly improve the simulation precision and the calculation efficiency. The predicted residual stresses after the UIT process using the proposed model are consistent with the measured results. A remarkable reduction in residual stress was achieved in the zone subjected to UIT. The tensile residual stresses on the surface of the treated area were reduced to compressive stresses. With the increase of the impact velocity and the coverage rate, the residual stresses on the surface and transition layers decreased and then tended to stabilize. The impact coverage rate should not exceed 200% to avoid damage and save time.
Cortical stimulation leads to shortened myelin sheaths and increased axonal branching in spared axons after cervical spinal cord injury
Authors: Kondiles B. R. , Murphy R. L. , Widman A. J. , Perlmutter S. I. , Horner P. J. 
Published: April 2023

AbstractNeural activity and learning lead to myelin sheath plasticity in the intact central nervous system (CNS), but this plasticity has not been well‐studied after CNS injury. In the context of spinal cord injury (SCI), demyelination occurs at the lesion site and natural remyelination of surviving axons can take months. To determine if neural activity modulates myelin and axon plasticity in the injured, adult CNS, we electrically stimulated the contralesional motor cortex at 10 Hz to drive neural activity in the corticospinal tract of rats with sub‐chronic spinal contusion injuries. We quantified myelin and axonal characteristics by tracing corticospinal axons rostral to and at the lesion epicenter and identifying nodes of Ranvier by immunohistochemistry. Three weeks of daily stimulation induced very short myelin sheaths, axon branching, and thinner axons outside of the lesion zone, where remodeling has not previously been reported. Surprisingly, remodeling was particularly robust rostral to the injury which suggests that electrical stimulation can promote white matter plasticity even in areas not directly demyelinated by the contusion. Stimulation did not alter myelin or axons at the lesion site, which suggests that neuronal activity does not contribute to myelin remodeling near the injury in the sub‐chronic period. These data are the first to demonstrate wide‐scale remodeling of nodal and myelin structures of a mature, long‐tract motor pathway in response to electrical stimulation. This finding suggests that neuromodulation promotes white matter plasticity in intact regions of pathways after injury and raises intriguing questions regarding the interplay between axonal and myelin plasticity.
Expert consensus on improving iron deficiency anemia management in obstetrics and gynecology in Asia
Authors: Leung Tsin Wah , Damodaran Premitha , Torres Rosalio , Chuncharunee Suporn , Chu Man Yee , Gamilla Zaida , Lim Nicholas R. , Luna Jericho , Huang Jian‐Pei , Li Wai Hou , Tran Thang Nhat , Sathar Jameela , Jaisamrarn Unnop 
Published: April 2023

AbstractIron deficiency anemia (IDA) is a major health burden among women in Asia. Key issues in IDA management in Asia are under‐diagnosis and under‐treatment. The lack of Asia‐specific guidelines, and suboptimal utilization of treatment compounds the management of IDA. To address these gaps, a panel of 12 experts in obstetrics, gynecology, and hematology from six regions in Asia convened to review current practices and clinical evidence and provide practical guidance on IDA diagnosis and management in Asian women. The Delphi approach was used to obtain objective opinions and attain consensus on statements pertaining to awareness, diagnosis, and management of IDA. In total, 79 statements attained consensus and are summarized to provide guidance on raising awareness of IDA and approaches for improved diagnosis and treatment of IDA among women in various settings: pregnancy, postpartum, heavy menstrual bleeding, gynecologic cancers, and perioperative care. This clinician‐led consensus integrates appropriate recommendations based on clinical evidence and best practices and is intended to guide decision making in the management of iron deficiency/IDA in women. The expert panel raises a call for timely diagnosis and utilization of appropriate treatment, including use of high‐dose intravenous iron, stringent blood management, and interdisciplinary collaboration, for optimization of IDA management among women in Asia.
Monolithic three‐dimensional integration of aligned carbon nanotube transistors for high‐performance integrated circuits
Authors: Fan Chenwei , Cheng Xiaohan , Xu Lin , Zhu Maguang , Ding Sujuan , Jin Chuanhong , Xie Yunong , Peng Lian‐Mao , Zhang Zhiyong 
Published: April 2023

AbstractCarbon nanotube field‐effect transistors (CNT FETs) have been demonstrated to exhibit high performance only through low‐temperature fabrication process and require a low thermal budget to construct monolithic three‐dimensional (M3D) integrated circuits (ICs), which have been considered a promising technology to meet the demands of high‐bandwidth computing and fully functional integration. However, the lack of high‐quality CNT materials at the upper layer and a low‐parasitic interlayer dielectric (ILD) makes the reported M3D CNT FETs and ICs unable to provide the predicted high performance. In this work, we demonstrate a multilayer stackable process for M3D integration of high‐performance aligned carbon nanotube (A‐CNT) transistors and ICs. A low‐κ (~3) interlayer SiO2 layer is prepared from spin‐on‐glass (SOG) through processes with a highest temperature of 220°C, presenting low parasitic capacitance between two transistor layers and excellent planarization to offer an ideal surface for the A‐CNT and device fabrication process. A high‐quality A‐CNT film with a carrier mobility of 650 cm2 V–1 s–1 is prepared on the ILD layer through a clean transfer process, enabling the upper CNT FETs fabricated with a low‐temperature process to exhibit high on‐state current (1 mA μm–1) and peak transconductance (0.98 mS μm–1). The bottom A‐CNT FETs maintain pristine high performance after undergoing the ILD growth and upper FET fabrication. As a result, 5‐stage ring oscillators utilizing the M3D architecture show a gate propagation delay of 17 ps and an active region of approximately 100 μm2, representing the fastest and the most compact M3D ICs to date.image
Biosilica source converted into mesoporous bioactive glass implanted for tendon‐bone healing
Authors: Lin Hsiu‐Mei , Chen Chih‐Hwa , Hsu Fu‐Yin , Wu Zhi‐Yuan , Wong Pei‐Chun 
Published: April 2023

AbstractIn this study, mesoporous bioactive glass (MBG) has been synthesized using a natural material, diatom. Then, the surface morphology, such as pore size and dimension, was observed by transmission electron microscope. The physical properties of MBG were quantitatively analyzed by X‐ray diffraction. Thermal properties were analyzed by thermogravimetric analysis. The cytotoxicity test was carried out by the MTT (3‐[4,5‐dimethylthaizol‐2‐yl]‐2,5‐diphenyltetrazolium bromide) assay to ensure biocompatibility. After that, MBG was mixed with gelatin to synthesize nanofiber matrix by an electrospinning process. The growth factors of platelet‐rich plasma have been activated by ethyl(dimethylaminopropyl) carbodiimide/N‐hydroxysuccinimide grafting on the surface of nanofiber matrix. Nanofiber structure of MBG has been observed by scanning electron microscope. In vivo biocompatibility and the situation of bone healing were analyzed by animal experiment; the histology result was observation by H&E and Masson's trichrome staining. The results show that the MBG has no residue of organic matter, pore size was around 10 nm. MBG nanofiber matrix can significantly improve the bone healing compared with control group (without MBG nanofiber matrix). In general, MBG nanofiber matrix can significantly enhance bone‐tendon healing and has great potential to be applied in the orthopedic field.