bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum optimal control theory for a molecule interacting with a plasmonic nanoparticle
Authors: Rosa Marta , Dall’Osto Giulia , Cammi Roberto , Corni Stefano 
Published: August 2023

AbstractIn this work, we extend the quantum optimal control theory of molecules subject to laser pulses to the case of molecules close to plasmonic metal nanoparticles. Explicitly including the nanoparticle dielectric response in the system Hamiltonian, the electronic dynamics for the molecule in the presence of the laser pulse is coupled with the polarization dynamics of the nanoparticle itself. A characteristic feature of a plasmonic environment is that it both amplifies the laser pulse field and introduces nonlocal time effects (a behavior of inherent interest for the quantum optimal control theory), impacting on the shape of the optimized light pulse. The optimal control theory is formulated using a genetic algorithm; numerical examples of a target molecule and nanoparticles of different shapes are presented and discussed.
Objective Definition and Optimized Strategy for “Biologically Borderline Resectable” Colorectal Liver Metastases
Authors: Takamoto Takeshi , Nara Satoshi , Ban Daisuke , Mizui Takahiro , Murase Yoshiki , Esaki Minoru , Shimada Kazuaki , Hashimoto Takuya , Makuuchi Masatoshi 
Published: August 2023

AbstractBackgroundThe prognostic benefit of preoperative chemotherapy leading to conversion surgery for unresectable colorectal liver metastases (CRLM) is well recognized, while that of neoadjuvant chemotherapy (NAC) compared with upfront surgery (UFS) for resectable CRLM is negligible. This study aims to assess the prognostic benefit and search for optimal indication of NAC for resectable advanced CRLM by establishing an objective definition of biologically borderline resectable (bBR) CRLM.MethodsA bicentric retrospective analysis of patients with CRLM undergoing curative‐intent initial liver resection between 2007 and 2021 was performed. An original classification matrix was established, which reassessed technical resectability using virtual hepatectomy and oncological favorability using Beppu’s nomogram. Patients with technically resectable but biologically unfavorable CRLM were classified into the bBR group. The propensity score matching analysis using preoperatively available factors was performed to assess long‐term outcomes of the bBR‐UFS and bBR‐NAC groups.ResultsOf 831 patients reviewed, 240 were categorized into the bBR group: bBR ‐UFS (n = 139) and bBR‐NAC (n = 101). Ten (10%) in the bBR‐NAC group (n = 101) experienced biological status change from unfavorable to favorable after NAC (Biological Conversion) and showed significantly longer overall survival (hazard ratio 5.63, 95% confidence interval 1.37–23.1; P = 0.016) than the bBR‐UFS group. However, after propensity score matching, no significant difference between the UFS and NAC groups (n = 67 for each) was found in long‐term outcomes.ConclusionsNAC for bBR‐CRLM did not enhance the prognostic impact of the following liver resection, except for a limited number of optimal candidates experiencing the Biological Conversion.
Consultation on UTUC II Stockholm 2022: diagnostics, prognostication, and follow-up—where are we today?
Authors: Sydén Filip , Baard Joyce , Bultitude Matthew , Keeley Francis Xavier , Rouprêt Morgan , Thomas Kay , Axelsson Tómas Andri , Jaremko Georg , Jung Helene , Malm Camilla , Proietti Silvia , Osther Palle Jørn Sloth , Brehmer Marianne 
Published: August 2023

Abstract
Purpose
To summarise the current knowledge regarding diagnostics, prognostication and follow-up in upper tract urothelial carcinoma (UTUC).

Methods
A scoping review combined with expert opinion was applied to provide an overview of the current research field. Based on the published literature and the experts’ own experience and opinions, consensus was reached through presentations and discussions at the meeting Consultation on UTUC II in Stockholm 2022.

Results
The strongest prognostic factors in UTUC are tumour grade and stage. They are correlated, and grade is used for indirect staging. The diagnostic examinations should include multiphase computed tomography urography (CTU) with corticomedullary phase, and urethrocystoscopy with cytology. If there is no clear diagnosis for clinical decision-making, ureterorenoscopy (URS) with focal cytology and biopsies should be performed. Both WHO classification systems (1973/1999 and 2004/2016) should be used. Novel biomarker tests are not yet widespread nor recommended for the detection of UTUC. Long-term, regular follow-up, including URS in patients who have had organ-sparing treatment, is important to check for tumour recurrences, intravesical recurrences, metastases and progression of the tumour.

Conclusion
Proper diagnostics with correct grading of UTUC are necessary for appropriate treatment decisions. The diagnostics should include CTU with corticomedullary phase, urine or bladder cytology, URS with focal barbotage cytology, and biopsies when needed for proper diagnosis and risk stratification. Regular, long-term follow-ups are fundamental, due to the high rate of recurrence and risk of progression.
Integrating US-guided FNAB, BRAFV600E mutation, and clinicopathologic characteristics to predict cervical central lymph-node metastasis in preoperative patients with cN0 papillary thyroid carcinoma
Authors: Ma Ning , Tian Hai-Ying , Yu Zhao-Yan , Zhu Xin , Zhao Dai-Wei 
Published: August 2023

Abstract
Background
The prevalence of cervical central lymph-node metastasis (CLNM) is high in patients with papillary thyroid carcinoma (PTC). There is considerable controversy surrounding the benefits of prophylactic central lymph-node dissection (pCLND) in patients with clinically negative central compartment lymph nodes (cN0). Therefore, it is crucial to accurately predict the likelihood of cervical CLNM before surgery to make informed surgical decisions.

Methods
Date from 214 PTC patients (cN0) who underwent partial or total thyroidectomy and pCLND at the Guizhou Provincial People's Hospital were collected and retrospectively analyzed. They were divided into two groups in accordance with cervical CLNM or not. Their information, including clinical characteristics, ultrasound (US) features, pathological results of fine-needle aspirations biopsy (FNAB), and other characteristics of the groups, was analyzed and compared using univariate and multivariate logistic regression analyses.

Results
A total of 214 patients were eligible in this study. Among them, 43.5% (93/214) of PTC patients had cervical CLNM, and 56.5% (121/214) did not. The two groups were compared using a univariate analyses, and there were no significant differences between the two groups in aspect ratio, boundary, morphology, component, and BRAFV600E (P > 0.05), and there were significant differences between gender, age, maximum tumor size, tumor location, capsule contact, microcalcifications, color Doppler flow imaging (CDFI), and Hashimoto's thyroiditis (HT) (P < 0.05). A multivariate logistic regression analysis was performed to further clarify the correlation of these indices. However, only age (OR = 2.455, P = 0.009), maximum tumor size (OR = 2.586, P = 0.010), capsule contact (OR = 3.208, P = 0.001), and CDFI (OR = 2.225, P = 0.022) were independent predictors of cervical CLNM. Combining these four factors, the area under the receiver-operating characteristic (ROC) curve for the joint diagnosis is 0.8160 (95% 0.7596–0.8725). Univariate analysis indicated that capsule contact (P = 0.001) was a possible predictive factor of BRAFV600E mutation.

Conclusions
In conclusion, four independent predictors of cervical CLNM, including age < 45 years, tumor size > 1.0 cm, capsule contact, and rich blood flow, were screened out. Therefore, a comprehensive assessment of these risk factors should be conducted when designing individualized treatment regimens for PTC patients.
Die Mischung macht’s? Das Shopping-Center wird zum Mixed-Use-Center
Authors: Heptig Marc 
Published: August 2023

ZusammenfassungGrün, kompakt, gemischt, resilient, inklusiv – die Assoziationen zur (Innen‑)Stadt der Zukunft sind vielfältig und zielen zumeist auf eine nachhaltige Stadtentwicklung ab. Inwiefern innerstädtische Shopping-Center diese Entwicklung durch Mischnutzung auf Immobilienebene (z. B. Büros, Wohnungen oder Kultur- und Bildungseinrichtungen) fördern können, soll in diesem Beitrag beleuchtet werden. Für diesen Zweck wurden neben einer Literatur‑, Dokumenten- und Onlinerecherche Experteninterviews geführt. Die Ergebnisse zeigen, dass mischgenutzte Shopping-Center sowohl Chancen als auch Risiken für eine belebte, resiliente und nachhaltige Stadt(entwicklung) bergen. Einerseits schaffen Umnutzungen und Nachverdichtung alternative Besuchsanlässe und verringern Leerstände, reduzieren die Flächenversiegelung, den Ressourcenverbrauch und potenziell den Verkehr sowie können bei der Einbindung nichtkommerzieller Nutzungen eine sozial integrierende Wirkung entfalten. Andererseits können mischgenutzte Shopping-Center den Zielsetzungen der Innenstadtentwicklung schaden, indem sie den Besuch bestehender Nutzungen obsolet machen, den (sozial) exklusiven Charakter des Centers durch hochpreisige Nutzungsangebote intensivieren und das Verkehrsaufkommen steigern. Wenn den negativen Auswirkungen jedoch durch frühzeitige Überlegungen hinsichtlich Nutzungsart und -anzahl sowie der Komplementarität mit dem bestehenden Innenstadtangebot vorgebeugt wird, können mischgenutzte Shopping-Center als ein möglicher Baustein zur sukzessiven Transformation der Innenstädte fungieren. Beruhend auf den Ergebnissen werden zum Abschluss des Beitrags Handlungsempfehlungen abgeleitet.
Intermittent scanning continuous glucose monitoring is safe and useful in postsurgical glucose monitoring after pancreatoduodenectomy
Authors: Fagher Katarina , Ekström Eva , Rystedt Jenny , Tingstedt Bobby , Andersson Bodil , Löndahl Magnus 
Published: August 2023

Abstract
Aims
Intermittently scanned continuous glucose monitoring (isCGM) systems have not been thoroughly evaluated during in-hospital stay, and there are concerns about accuracy during various conditions. Patients undergoing pancreatoduodenectomy have an increased risk of hyperglycaemia after surgery which is aggravated by parenteral nutrition therapy. This study aims to evaluate glycaemic control and safety during insulin infusion in a surgical non-ICU ward, using a hybrid glucose monitoring approach with isCMG and periodic point-of-care (POC) testing.

Methods
We prospectively included 100 patients with a resectable pancreatic tumour. After surgery, continuous insulin infusion was initiated when POC glucose was > 7 mmol/l and titrated to maintain glucose between 7 and 10 mmol/l. Glucose was monitored with isCGM together with intermittent POC, every 3–6 h. Median absolute relative difference (MARD) and hypoglycaemic events were evaluated. Mean glucose was compared with a historic control (n = 100) treated with multiple subcutaneously insulin injections, monitored with POC only.

Results
The intervention group (isCGM/POC) had significantly lower POC glucose compared with the historic control group (8.8 ± 2.2 vs. 10.4 ± 3.4 mmol/l, p < 0.001). MARD was 17.8% (IQR 10.2–26.7). isCGM readings were higher than POC measurements in 91% of the paired cases, and isCGM did not miss any hypoglycaemic event. About 4.5% of all isCGM readings were < 3.9 mmol/l, but only six events were confirmed with POC, and none was < 3.0 mmol/l.

Conclusions
A hybrid approach with isCGM/POC is a safe and effective treatment option in a non-ICU setting after pancreatoduodenectomy.
Evaluating cone cut in rectangular collimation in intraoral radiography: application of ALADA and radiation stewardship
Authors: Clark-Perry D. , Berkhout W. E. R. , Sanderink G. C. , Slot D. E. 
Published: August 2023

AbstractObjectiveRectangular collimation is a popular method used in intraoral radiography to reduce patient exposure to ionizing radiation. One of the perceived drawbacks of rectangular collimation is the possibility of an increase in cone cut errors ultimately impacting the diagnostic value of the radiographs. Thus, the aim of this study was to explore the frequency of cone cut errors in radiographs taken using a rectangular collimator.Materials and methodsRadiographs taken using PSP plates at Academic Center for Dentistry Amsterdam in the Netherlands by staff and students from January to December 2015 were assessed for cone cut errors. The radiographs were grouped as bitewings, front teeth, inferior premolars and molars, and superior premolars and molars and categorized as no cone cut, cone cut but diagnostically usable, and cone cut but diagnostically not usable. The results were entered into Microsoft Excel and analyzed thereafter.ResultsA total of 53,684 radiographs were assessed, 79% had no cone cut errors and consequently 21% had some degree of cone cut. However, the diagnostic value was unaffected in 18% of the radiographs with cone cut. Only 3% of the radiographs were deemed diagnostically unusable due to cone cut. The most common area of cone cut was in the premolar and molar areas while cone cut in the front teeth was least likely to be diagnostically unusable.ConclusionCone cut from the use of a rectangular collimator does not seem to result in an increase of diagnostically unusable radiographs. Thus, rectangular collimation should be preferred as it decreases the amount of radiation exposure to the patient while producing diagnostically usable radiographs and thus allowing the dental professional to adhere to the ALADA principle and practice radiation stewardship.Clinical relevanceScientific rationale for the study: rectangular collimation is a method used to reduce patient exposure to ionizing radiation; however, this benefit is negligible if radiographs must be retaken due to cone cut errors that make the radiograph diagnostically unusable. Therefore, the aim of this study was to explore the frequency of cone cut in radiographs taken using a rectangular collimator.Principal findings: cone cut was observed in 21% of the radiographs; however, only 3% of the radiographs were considered diagnostically unusable.Practical implications: rectangular collimation does not result in a high number of diagnostically unusable radiographs and should be used to reduce patient exposure to ionizing radiation.
Association between self-reported race and ethnicity and myositis-specific autoantibodies in a diverse cohort of patients with inflammatory myopathy
Authors: Beam Michael J. , Montgomery Anna , Anastasiou Christine , Schmajuk Gabriela 
Published: August 2023

AbstractMyositis-specific autoantibodies (MSAs) are highly specific biomarkers for idiopathic inflammatory myopathies (IIMs). We investigated whether self-reported race and ethnicity were associated with the presence of specific MSAs. Charts of patients with IIM seen at 3 large healthcare systems in the same US city were reviewed. Demographic data and MSA test results were abstracted. Associations between race and ethnicity and presence of MSAs were analyzed using bivariate analysis and further characterized using separate unadjusted and adjusted logistic regression models. One hundred twenty-one subjects were included (19% Asian, 10% Black or African American, 27% Latinx or Hispanic, 36% non-Hispanic White, and 7% Other). In a bivariate analysis, anti-Jo-1 and anti-MDA5 autoantibodies were associated with race and ethnicity (p = 0.03 and 0.02, respectively). Black or African American subjects had increased odds of a positive anti-Jo-1 result compared to non-Hispanic White subjects on unadjusted logistic regression analysis (OR 8.61, 95% CI 1.61–46.07), although after adjustment for age and gender this finding was not significant. Subjects categorized as Other had increased odds of a positive anti-MDA5 result compared to non-Hispanic White subjects on both unadjusted (OR 55.0, 95% CI 2.02–1493) and adjusted analyses (OR 44.8, 95% CI 1.55–1298). Anti-Jo-1 and anti-MDA5 autoantibodies were significantly associated with race and ethnicity on bivariate analysis. Black or African American subjects had increased odds of positive anti-Jo-1 autoantibody on unadjusted, but not adjusted, logistic regression analysis. Subjects characterized as Other had increased odds of positive anti-MDA5 autoantibody, although confidence intervals were wide.

Key Points• Association found between MSAs and race and ethnicity in diverse US cohort• Anti-Jo-1 and anti-MDA5 associated with race and ethnicity in bivariate analyses
On being a Hydra with, and without, a nervous system: what do neurons add?
Authors: Hanson Alison 
Published: August 2023

AbstractThe small freshwater cnidarian Hydra has been the subject of scientific inquiry for over 300 years due to its remarkable regenerative capacities and apparent immortality. More recently, Hydra has been recognized as an excellent model system within neuroscience because of its small size, transparency, and simple nervous system, which allow high-resolution imaging of its entire nerve net while behaving. In less than a decade, studies of Hydra’s nervous system have yielded insights into the activity of neural circuits in vivo unobtainable in most other animals. In addition to these unique attributes, there is yet another lesser-known feature of Hydra that makes it even more intriguing: it does not require its neural hardware to live. The extraordinary ability to survive the removal and replacement of its entire nervous system makes Hydra uniquely suited to address the question of what neurons add to an extant organism. Here, I will review what early work on nerve-free Hydra reveals about the potential role of the nervous system in these animals and point towards future directions for this work.
A prospective prognostic signature for pancreatic adenocarcinoma based on ubiquitination-related mRNA-lncRNA with experimental validation in vitro and vivo
Authors: Wang Zhizhou , Yuan Qihang , Chen Xu , Luo Fei , Shi Xueying , Guo Fangyue , Ren Jie , Li Shuang , Shang Dong 
Published: August 2023

AbstractUbiquitination-related genes (URGs) exerted a crucial part in a variety of human disease disorders; however, their association with pancreatic adenocarcinoma (PAAD) had yet to be clearly described. We aimed to comprehensively characterize the contributions of URGs in PAAD through in silico analysis and experimental validation, and then identified a robust mRNA-lncRNA-based molecular prognostic panel for patients with PAAD using bulk RNA-sequencing and single-cell RNA-sequencing data. Initially, we collected the multi-omics data from TCGA platform to depict a comprehensive landscape of URGs in pan-cancer. Furthermore, we were accurate to PAAD for in-depth analysis. Significant differences of the activation of ubiquitination pathways and the expression of URGs were detected between normal and malignant cells. Unsupervised hierarchical clustering determined two PAAD subtypes with distinct clinical outcomes, ubiquitination pathway activities, immune microenvironment, and functional annotation characteristics. The expression profiles of ubiquitination-associated mRNAs and lncRNAs in the training and validation datasets were utilized to develop and verify a novel ubiquitination-related mRNA-lncRNA prognostic panel, which had a satisfied prediction efficiency. Our ubiquitination-associated model could function as an effective prognostic index and outperformed four other recognized panels in evaluating PAAD patients’ survival status. Tumor immune microenvironment, mutation burden, and chemotherapy response were intensively explored to demonstrate the underlying mechanism of prognostic difference according to our panel. Our findings also revealed that FTI-277, a farnesyltransferase inhibitor, had a better curative effect in high-risk patients, while MK-2206, an Akt allosteric inhibitor, had a superior therapeutic effect in low-risk patients. The real-time PCR results uncovered the RNA expression of AC005062.1 in all the three PAAD cell lines was elevated several thousandfold. In conclusion, our URGs-based classification panel could be triumphantly served as a prediction tool for survival evaluation in patients with PAAD, and the genes in this panel could be developed as a potential target in PAAD therapy.
Primary Hypothyroidism and Alzheimer’s Disease: A Tale of Two
Authors: AlAnazi Faisal Holil , Al-kuraishy Hayder M. , Alexiou Athanasios , Papadakis Marios , Ashour Mohamed H. Mazhar , Alnaaim Saud A. , Elhussieny Omnya , Saad Hebatallah M. , Batiha Gaber El-Saber 
Published: August 2023

AbstractHypothyroidism (HPT) HPT could be a risk factor for the development and progression of Alzheimer’s disease (AD). In addition, progressive neurodegeneration in AD may affect the metabolism of thyroid hormones (THs) in the brain causing local brain HPT. Hence, the present review aimed to clarify the potential association between HPT and AD. HPT promotes the progression of AD by inducing the production of amyloid beta (Aβ) and tau protein phosphorylation with the development of synaptic plasticity and memory dysfunction. Besides, the metabolism of THs is dysregulated in AD due to the accumulation of Aβ and tau protein phosphorylation leading to local brain HPT. Additionally, HPT can affect AD neuropathology through various mechanistic pathways including dysregulation of transthyretin, oxidative stress, ER stress, autophagy dysfunction mitochondrial dysfunction, and inhibition of brain-derived neurotrophic factor. Taken together there is a potential link between HPT and AD, as HPT adversely impacts AD neuropathology and the reverse is also true.
Graphical Abstract
Constructing irreducible polynomials recursively with a reverse composition method
Authors: Graner Anna-Maurin , Kyureghyan Gohar M. 
Published: August 2023

AbstractWe suggest a construction of the minimal polynomial $$m_{\beta ^k}$$

m

β
k

of $$\beta ^k\in {\mathbb {F}}_{q^n}$$

β
k

∈

F

q
n

over $${\mathbb {F}}_q$$

F
q

from the minimal polynomial $$f= m_\beta $$

f
=

m
β

for all positive integers k whose prime factors divide $$q-1$$

q
-
1

. The computations of our construction are carried out in $${\mathbb {F}}_q$$

F
q

. The key observation leading to our construction is that for $$k \mid q-1$$

k
∣
q
-
1

holds $$\begin{aligned} m_{\beta ^k}(X^k) = \prod _{j=1}^{\frac{k}{t}} \zeta _{k}^{-jn} f (\zeta _{k}^j X), \end{aligned}$$

m

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k

(

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k

)

=

∏

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=
1

k
t

ζ

k

-
j
n

f

(

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j

X
)

,

where $$t= \max \{m\in {\mathbb {N}}: m \mid \gcd (n,k), f(X) = g (X^m), g \in {\mathbb {F}}_q[X]\}$$

t
=
max
{
m
∈
N
:
m
∣
gcd

(
n
,
k
)

,
f

(
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)

=
g

(

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m

)

,
g
∈

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q

[
X
]

}

and $$\zeta _{k}$$

ζ
k

is a primitive k-th root of unity in $${\mathbb {F}}_q$$

F
q

. The construction allows to construct a large number of irreducible polynomials over $${\mathbb {F}}_q$$

F
q

of the same degree. Since different applications require different properties, this large number allows the selection of the candidates with the desired properties.