bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic adherence and assessment of satisfaction patients with multiple myeloma treated with immunomodulatory drugs in a “real-world” study: Experiences of the Polish Myeloma Group
Authors: Charliński Grzegorz , Grząśko Norbert , Bołkun Łukasz , Sawicki Waldemar , Paczkowska Edyta , Druzd-Sitek Agnieszka , Usnarska-Zubkiewicz Lidia , Butrym Aleksandra , Wiater Elżbieta , Boguradzki Piotr , Budziszewska Bożena , Wojciechowska Małgorzata , Mordak-Domagała Monika , Jurczyszyn Artur 
Published: September 2023

Introduction Therapeutic adherence (TA) is one of the most important factors influencing the effectiveness of treatment. Oral anti-cancer drugs are increasingly used to treat malignancy including multiple myeloma (MM). Our study aimed to determine TA of patients with MM treated with IMiDs, to identify TA risk factors, and to determine satisfaction with medical care during the treatment with IMiDs. Methods A cross-sectional survey-based study involving adult patients with MM treated with IMiDs. Results Between January 2021 and May 2021, 267 patients with MM were enrolled in the study. The dosing schedule was declared as easy by 71.8% of patients, as standard for 24.0%, and difficult for 4.2% of patients. During MM treatment, 85.0% of patients did not skip any IMiDs dose, and 87.6% did not skip the IMiDs dose in the last cycle of chemotherapy. Identified factors affecting TA included the treatment duration and education level. In addition, depending on the patient’s well-being, gender, and household companionship influenced TA. Satisfaction with medical care during the treatment with IMiDs was declared by 95.5% of patients with MM. In our cohort, 95.5% of patients were satisfied with the information they received from the hematologist during treatment with IMiDs. Conclusions Patients with MM treated with IMiDs are highly adherent to treatment. With time from the beginning of treatment, patients need more attention and motivation to adhere to the therapy rules.
Comparison of Glycemic Control Between In-Person and Virtual Diabetes Consults in Hospitalized Patients With Diabetes
Authors: Luzuriaga Maria Gracia , Lieberman Monica , MA Ruixuan , Casula Sabina , Lagari-Libhaber Violet , Messinger Shari , Li Hua , Miranda Bresta , Baidal David A. , Mizrachi Ernesto Bernal , Iacobellis Gianluca , Garg Rajesh , Vendrame Francesco 
Published: September 2023

Background: There is limited evidence that the diabetes in-person consult in hospitalized patients can be replaced by a virtual consult. During COVID-19 pandemic, the diabetes in-person consult service at the University of Miami and Miami Veterans Affairs Healthcare System transitioned to a virtual model. The aim of this study was to assess the impact of telemedicine on glycemic control after this transition. Methods: We retrospectively analyzed glucose metrics from in-person consults (In-person) during January 16 to March 14, 2020 and virtual consults during March 15 to May 14, 2020. Data from virtual consults were analyzed by separating patients infected with COVID-19, who were seen only virtually (Virtual-COVID-19-Pos), and patients who were not infected (Virtual-COVID-19-Neg), or by combining the two groups (Virtual-All). Results: Patient-day–weighted blood glucose was not significantly different between In-person, Virtual-All, and Virtual-COVID-19-Neg, but Virtual-COVID-19-Pos had significantly higher mean ± SD blood glucose (mg/dL) compared with others (206.7 ± 49.6 In-person, 214.6 ± 56.2 Virtual-All, 206.5 ± 57.2 Virtual-COVID-19-Neg, 229.7 ± 51.6 Virtual-COVID-19-Pos; P = .015). A significantly less percentage of patients in this group also achieved a mean ± SD glucose target of 140 to 180 mg/dL (23.8 ± 22.5 In-person, 21.5 ± 20.5 Virtual-All, 25.3 ± 20.8 Virtual-COVID-19-Neg, and 14.4±18.1 Virtual-COVID-19-Pos, P = .024), but there was no significant difference between In-person, Virtual-All, and Virtual-COVID-19-Neg. The occurrence of hypoglycemia was not significantly different among groups. Conclusions: In-person and virtual consults delivered by a diabetes team at an academic institution were not associated with significant differences in glycemic control. These real-world data suggest that telemedicine could be used for in-patient diabetes management, although additional studies are needed to better assess clinical outcomes and safety.
Brief mindful yoga intervention fails to prevent depression-related outcomes after a dysphoric affect induction
Authors: Vollbehr Nina K. , Hoenders H. J. Rogier , Bartels-Velthuis Agna A. , de Jong Peter J. , Ostafin Brian D. 
Published: September 2023

Objectives This study was designed to test whether a brief mindful yoga intervention can prevent depression-related responses to dysphoric events. Methods One-hundred-75 undergraduate participants were assigned to one of four conditions in a single-session study. Three conditions received a dysphoric affect induction. Before the induction, participants completed a 20-minute intervention consisting of (a) mindful yoga, (b) stretching, or (c) relaxation control. The fourth condition consisted of a neutral affect induction to examine the validity of the dysphoric affect induction. We hypothesized that compared to relaxation control and stretching, mindful yoga participants would show less: (H1) state depressed affect; (H2) rumination; and (H3) attentional bias toward depression-related words. Results Validity checks indicated that the dysphoric affect induction led to greater state depressed affect and rumination, but not attentional bias. Compared to relaxation control, mindful yoga did not show less state depression, rumination, or attentional bias. The stretching group showed less depression and rumination. Conclusions The results do not provide support for mindful yoga in preventing depression-related reactivity. It may be that when given in a brief, one-time dose, stretching is the better choice for preventing negative outcomes from a subsequent dysphoric experience.
The Association Between Depression and Substance Use Among Primary Care Patients With Comorbid Medical and Behavioral Health Conditions
Authors: McGovern Mark P. , Dunn Julia , Bonnell Levi N. , Leibowitz George , Waddell Elizabeth , Rose Gail , Littenberg Benjamin 
Published: September 2023

Introduction: The scope of primary care increasingly encompasses patient behavioral health problems, manifest typically through depression screening and treatment. Although substance use is highly comorbid with depression, it is not commonly identified and addressed in the primary care context. This study aimed to examine the association between the likelihood of substance use disorder and increased depression severity, both cross-sectionally and longitudinally, among a sample of 2409 patients from 41 geographically dispersed and diverse primary care clinics across the US. Methods: This is secondary analysis of data obtained from a multi-site parent study of integrated behavioral health in primary care, among patients with both chronic medical and behavioral health conditions. Patient reported outcome surveys were gathered from patients at 3 time points. The primary care practices were blind to which of their patients completed surveys. Included were standardized measures of depression severity (Patient Health Questionnaire—9) [PHQ-9] and substance use disorder likelihood (Global Appraisal of Individual Needs—Short Screener [GSS]). Results: Four percent of the study population screened positive for substance use disorder. PHQ-9 scores indicated depression among 43% of all patients. There was a significant association between the likelihood of substance use disorder and depression initially, at a 9-month follow-up, and over time. These associations remained significant after adjusting for age, gender, race, ethnicity, education, income, and other patient and contextual characteristics. Conclusions: The findings suggest that substance use disorder is associated with depression severity cross-sectionally and over time. Primary care clinics and health systems might consider implementing substance use screening in addition to the more common screening strategies for depression. Especially for patients with severe depression or those who do not respond to frontline depression treatments, the undermining presence of a substance use disorder should be explored.
Moving toward disease modification in polycythemia vera
Authors: Bewersdorf Jan Philipp , How Joan , Masarova Lucia , Bose Prithviraj , Pemmaraju Naveen , Mascarenhas John , Rampal Raajit K. 
Published: September 2023

Abstract
Polycythemia vera (PV) belongs to the BCR-ABL1–negative myeloproliferative neoplasms and is characterized by activating mutations in JAK2 and clinically presents with erythrocytosis, variable degrees of systemic and vasomotor symptoms, and an increased risk of both thromboembolic events and progression to myelofibrosis and acute myeloid leukemia (AML). Treatment selection is based on a patient’s age and a history of thrombosis in patients with low-risk PV treated with therapeutic phlebotomy and aspirin alone, whereas cytoreductive therapy with either hydroxyurea or interferon alfa (IFN-α) is added for high-risk disease. However, other disease features such as significant disease-related symptoms and splenomegaly, concurrent thrombocytosis and leukocytosis, or intolerance of phlebotomy can constitute an indication for cytoreductive therapy in patients with otherwise low-risk disease. Additionally, recent studies demonstrating the safety and efficacy (ie, reduction in phlebotomy requirements and molecular responses) of ropegylated IFN-α2b support its use for patients with low-risk PV. Additionally, emerging data suggest that early treatment is associated with higher rates of molecular responses, which might eventually enable time-limited therapy. Nonetheless, longer follow-up is needed to assess whether molecular responses associate with clinically meaningful outcome measures such as thrombosis and progression to myelofibrosis or AML. In this article, we provide an overview of the current and evolving treatment landscape of PV and outline our vision for a patient-centered, phlebotomy-free, treatment approach using time-limited, disease-modifying treatment modalities early in the disease course, which could ultimately affect the natural history of the disease.
Grinding Characteristics of MoS2-Coated Brazed CBN Grinding Wheels in Dry Grinding of Titanium Alloy
Authors: Zhao Junshuai , Zhao Biao , Ding Wenfeng , Wu Bangfu , Han Ming , Xu Jiuhua , Liu Guoliang 
Published: September 2023

AbstractAs an important green manufacturing process, dry grinding has problems such as high grinding temperature and insufficient cooling capacity. Aiming at the problems of sticking and burns in dry grinding of titanium alloys, grinding performance evaluation of molybdenum disulfide (MoS2) solid lubricant coated brazed cubic boron carbide (CBN) grinding wheel (MoS2-coated CBN wheel) in dry grinding titanium alloys was carried out. The lubrication mechanism of MoS2 in the grinding process is analyzed, and the MoS2-coated CBN wheel is prepared. The results show that the MoS2 solid lubricant can form a lubricating film on the ground surface and reduce the friction coefficient and grinding force. Within the experimental parameters, normal grinding force decreased by 42.5%, and tangential grinding force decreased by 28.1%. MoS2 lubricant can effectively improve the heat dissipation effect of titanium alloy grinding arc area. Compared with common CBN grinding wheel, MoS2-coated CBN wheel has lower grinding temperature. When the grinding depth reaches 20 μm, the grinding temperature decreased by 30.5%. The wear of CBN grains of grinding wheel were analyzed by mathematical statistical method. MoS2 lubricating coating can essentially decrease the wear of grains, reduce the adhesion of titanium alloy chip, prolong the service life of grinding wheel, and help to enhance the surface quality of workpiece. This research provides high-quality and efficient technical support for titanium alloy grinding.
A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells
Authors: Olson Christopher , Zhang Pengyang , Ku Joy , Flojo Renceh , Boyes Darin , Lu Biao 
Published: September 2023

Abstract
Background
Exosomes, a special subtype of extracellular vesicles derived from human cells, serve as vital mediators of intercellular communication by transporting diverse bioactive cargos, including proteins and enzymes. However, the underlying mechanisms governing exosome secretion and regulation remain poorly understood. In this study, we employed a dual-reporter system consisting of bioluminescent Gaussia luciferase and fluorescent proteins to investigate the dynamics and regulation of exosome secretion in cultured human cells.

Results
Our results demonstrated that the engineered dual-reporters effectively monitored both exosome-mediated and ER-Golgi-mediated secretory pathways in a specific and quantitative manner. Notably, we observed distinct characteristics of exosome-mediated protein secretion, including significantly lower capacity and different dynamics compared to the ER-Golgi pathway. This phenomenon was observed in human kidney 293T cells and liver HepG2 cells, emphasizing the conserved nature of exosome-mediated secretion across cell types. Furthermore, we investigated the impact of brefeldin A (BFA), an inhibitor of ER-to-Golgi membrane trafficking, on protein secretion. Interestingly, BFA inhibited protein secretion via the ER-Golgi pathway while stimulating exosome-mediated protein secretion under same experimental conditions.

Conclusions
Collectively, our study highlights the utility of the dual-reporter system for real-time monitoring and quantitative analysis of protein secretion through conventional ER-Golgi and unconventional exosome pathways. Moreover, our findings unveil distinct features of exosome-mediated protein secretion, shedding light on its differential capacity, dynamics, and regulatory mechanisms compared to ER-Golgi-mediated proteins in human cells.
Reply: Correspondence on NanoVar’s performance outlined by Jiang T. et al. in ‘Long-read sequencing settings for efficient structural variation detection based on comprehensive evaluation’
Authors: Jiang Tao , Liu Shiqi , Guo Hongzhe 
Published: September 2023

AbstractWe published a paper in BMC Bioinformatics comprehensively evaluating the performance of structural variation (SV) calling with long-read SV detection methods based on simulated error-prone long-read data under various sequencing settings. Recently, C.Y.T. et al. wrote a correspondence claiming that the performance of NanoVar was underestimated in our benchmarking and listed some errors in our previous manuscripts. To clarify these matters, we reproduced our previous benchmarking results and carried out a series of parallel experiments on both the newly generated simulated datasets and the ones provided by C.Y.T. et al. The robust benchmark results indicate that NanoVar has unstable performance on simulated data produced from different versions of VISOR, while other tools do not exhibit this phenomenon. Furthermore, the errors proposed by C.Y.T. et al. were due to them using another version of VISOR and Sniffles, which caused many changes in usage and results compared to the versions applied in our previous work. We hope that this commentary proves the validity of our previous publication, clarifies and eliminates the misunderstanding about the commands and results in our benchmarking. Furthermore, we welcome more experts and scholars in the scientific community to pay attention to our research and help us better optimize these valuable works.
Correspondence on NanoVar’s performance outlined by Jiang T. et al. in “Long-read sequencing settings for efficient structural variation detection based on comprehensive evaluation”
Authors: Tham Cheng Yong , Benoukraf Touati 
Published: September 2023

AbstractA recent paper by Jiang et al. in BMC Bioinformatics presented guidelines on long-read sequencing settings for structural variation (SV) calling, and benchmarked the performance of various SV calling tools, including NanoVar. In their simulation-based benchmarking, NanoVar was shown to perform poorly compared to other tools, mostly due to low SV recall rates. To investigate the causes for NanoVar's poor performance, we regenerated the simulation datasets (3× to 20×) as specified by Jiang et al. and performed benchmarking for NanoVar and Sniffles. Our results did not reflect the findings described by Jiang et al. In our analysis, NanoVar displayed more than three times the F1 scores and recall rates as reported in Jiang et al. across all sequencing coverages, indicating a previous underestimation of its performance. We also observed that NanoVar outperformed Sniffles in calling SVs with genotype concordance by more than 0.13 in F1 scores, which is contrary to the trend reported by Jiang et al. Besides, we identified multiple detrimental errors encountered during the analysis which were not addressed by Jiang et al. We hope that this commentary clarifies NanoVar's validity as a long-read SV caller and provides assurance to its users and the scientific community.
Changes in the lodging resistance of winter wheat from 1950s to the 2020s in Henan Province of China
Authors: Wang Yang , Pan Yonghui , Zhao Fulin , Meng Xiangping , Li Qun , Huang Yudfang , Ye Youliang 
Published: September 2023

Abstract
Background
Lodging is a major factor contributing to yield loss and constraining the mechanical harvesting of wheat crops. Genetic improvement through breeding effectively reduced the lodging and improved the grain yield, however, the physiological mechanisms involved in providing resistance to lodging are different in the breeding stage and are not clearly understood. The purpose of this study was to compare the differences in the lodging resistance (LR) of the wheat varieties released during the different decades and to explore the effect of the application of nitrogen (N) fertilizer on the plasticity of LR.

Results
A field study was conducted during the cultivation seasons of 2019–2020 and 2020–2021, in soil supplemented with three N levels: N0 (0 kg ha–1), N180 (200 kg ha–1), and N360 (360 kg ha–1) using eight varieties of wheat released for commercial cultivation from 1950 to date. The results obtained showed that genetic improvement had significantly enhanced the LR and grain yield in wheat. In the first breeding stage (from 1950 to 1980s) the lodging resistant index increased by 15.0%, which was primarily attributed to a reduced plant height and increased contents of cellulose, Si, and Zn. In the second breeding stage (the 1990s–2020s) it increased by 172.8%, which was mainly attributed to an increase in the stem diameter, wall thickness, and the contents of K, Ca, Fe, Mn, and Cu. The application of N fertilizer improved the grain yield but reduced the LR in wheat. This was mainly due to an increase in plant height resulting in an elevation of the plant center of gravity, a decrease in the contents of cellulose, and a reduction in the area of large-sized vascular bundles in the stems, even if N supplementation increased the concentrations of K, Ca, and Si.

Conclusion
Although breeding strategies improved the stem strength, the trade-off between the grain yield and LR was more significantly influenced by the addition of N. Overcoming this peculiar situation will serve as a breakthrough in improving the seed yield in wheat crops in the future.
Chronic constrictive pericarditis: a rare cardiac involvement in primary Sjögren’s syndrome
Authors: Duarte Fabiana , Oliveira Luís , Fontes Tomás , Ramos Sância , Dourado Raquel , Martins Dinis 
Published: September 2023

Abstract
Background
Constrictive pericarditis represents a chronic condition and systemic inflammatory diseases are a known, yet uncommon, cause. Pericardial involvement is seldom reported in primary Sjögren’s syndrome, usually occurring in association with pericardial effusion or pericarditis.
We report a case of constrictive pericarditis with an insidious course and unusual evolution associated with primary Sjögren’s syndrome. Due to the challenging nature of the diagnosis, clinical suspicion and multimodality imaging are essential for early identification and prompt initiation of treatment. Long-term outcomes remain uncertain.
To the best of our knowledge, no other cases linking this autoimmune disease to constrictive pericarditis have been reported.

Case presentation
We present the case of a 48-year-old male patient with moderate alcohol habits and a history of two prior hospitalizations. On the first, the patient was diagnosed with primary Sjögren’s syndrome after presenting with pleural effusion and ascites, and empirical corticosteroid regiment was initiated. On the second, two-years later, he was readmitted with complaints of dyspnea and abdominal distension. Thoracic computed tomography revealed a localized pericardial thickening and a thin pericardial effusion, both of which were attributed to his rheumatic disease. A liver biopsy showed hepatic peliosis, which was considered to be a consequence of glucocorticoid therapy. Diuretic therapy was adjusted to symptom-relief, and a tapering corticosteroid regimen was adopted.
Four years after the initial diagnosis, the patient was admitted again with recurrent dyspnea, orthopnea and ascites. At this time, constrictive pericarditis was diagnosed and a partial pericardiectomy was performed.
Although not completely asymptomatic, the patient reported clinical improvement since the surgery, but still with a need for baseline diuretic therapy.

Conclusion
Albeit uncommon, connective tissue disorders, such as primary Sjögren’s syndrome, should be considered as a potential cause of constrictive pericarditis, especially in young patients with no other classical risk factors for constriction.
In this case, after excluding possible infectious, neoplastic and autoimmune conditions, a primary Sjögren´s syndrome in association with constrictive pericarditis was assumed. This case presents an interesting and challenging clinical scenario, highlighting the importance of clinical awareness and the use of multimodal cardiac imaging for early recognition and treatment.