bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-sectional study of workplace violence on work engagement among Chinese nurses: the mediating role of psychological resilience
Authors: Chen Miao , Liao Xiaoli , Xie Hao 
Published: January 2025

ObjectivesThis study aimed to investigate the status of workplace violence, psychological resilience and work engagement, and explore the potential mediating role of psychological resilience in the relationship between workplace violence and work engagement among Chinese nurses.DesignA cross-sectional survey was conducted among a convenience sample of clinical registered nurses.SettingA convenience sample of clinical registered nurses was recruited from affiliated hospitals of Hunan University of Chinese Medicine.ParticipantsA total of 1725 questionnaires were received, of which 1571 were deemed valid, resulting in an effective response rate of 91.07%. The final sample consisted of 1571 clinical registered nurses with a mean age of 31.65±7.16 years.Outcome measuresData were collected through an online questionnaire comprising a general information form, the Workplace Violence Scale (WVS), Connor-Davidson Resilience Scale (CD-RS) and Utrecht Work Engagement Scale (UWES). Descriptive analysis, correlation analysis, and mediation analysis were performed using IBM SPSS Statistics software.ResultsThis cross-sectional investigation recruited a convenience sample of 1571 clinical registered nurses, who encountered multiple types of workplace violence in the past year. Pearson correlation analysis indicated negative associations between workplace violence and work engagement (r=−0.505, p<0.01), as well as between workplace violence and psychological resilience (r=−0.523, p<0.01). Mediation analysis revealed that psychological resilience partially mediated the relationship between workplace violence and work engagement, with the mediation effect accounting for 66.67% of the total effect.ConclusionsNurses exposed to workplace violence demonstrated decreased work engagement, while psychological resilience acted as a protective factor to mitigate the adverse impacts of workplace violence on work engagement. These findings provide a theoretical basis for interventions that equip nurses with resilience to combat workplace violence and improve work engagement.
Trials and tribulations: a qualitative exploration of researcher perspectives on navigating the challenges of health system implementation research
Authors: Morrow April , Tyedmers Elijah , Debono Deborah , Chan Priscilla , Steinberg Julia , Tiernan Gabriella , Hogden Emily , Taylor Natalie 
Published: January 2025

ObjectiveWhile researchers are crucial to the successful delivery of implementation trials, their perspectives are rarely captured in the evaluation of these trials. This qualitative study aimed to capture the experiences of a small research team coordinating a large, multisite implementation trial (the Hide and Seek Project) in the Australian healthcare setting.DesignA qualitative approach was used, whereby members of the Hide and Seek Project research team were invited to take part in semistructured focus groups led by an external facilitator. The focus group guide was developed to explore the experiences of the research team (including challenges and lessons learnt) as they moved through key study activities. Focus groups were transcribed verbatim and analysed using an inductive thematic approach. Barriers and facilitators identified within themes were deductively coded to domains of the updated Consolidated Framework for Implementation Research.SettingParticipants were recruited from a research organisation based in Sydney, Australia.ParticipantsA total of seven researcher and administering institution participants took part in four focus groups.ResultsAnalysis highlighted the following themes: navigating bureaucracy, distinguishing implementation trials from clinical trials, the impact of COVID-19, balancing rigour and pragmatism in implementation trials, data access and complexity of analysis, and key learnings and future directions (subthemes: building relationships with ethics committees, communicating implementation concepts, streamlining of the implementation and research approach).ConclusionsFindings highlight the need for streamlining current administrative and ethical review processes, as well as procedures that allow greater flexibility for researchers to respond to challenges as they arise. Lessons learnt by the Hide and Seek Project team hold potential relevance for fellow researchers involved in coordinating implementation trials across diverse contexts.
Investigating male factors and their relationships with reproductive health outcomes: a case-control study protocol for Towards Optimal Fertility, Fathering, and Fatherhood studY (TOFFFY) in Singapore
Authors: Ku Chee Wai , Pek Jun Wei , Cheung Yin Bun , Tharmalingam Durgahshree Melissa D/O , Chan Melinda , Lee Yie Hou , Godfrey Keith , Yap Fabian , Chan Jerry Kok Yen , Loy See Ling 
Published: January 2025

IntroductionDespite the global prevalence of low fertility rates, male contributions to fertility and reproductive health outcomes have been understudied. This study aims to investigate the male contribution to fertility and explore the underlying biological mechanisms. Specifically, we aim to (1) identify male factors associated with successful pregnancy, (2) develop a fertility index incorporating modifiable factors for both males and females to predict pregnancy rate and (3) explore the relationship of male modifiable factors with semen parameters and molecular characteristics.Methods and analysisWe will conduct an unmatched case-control study involving 240 couples with impaired male fertility (cases) and 240 couples with normal male fertility (controls). Between July 2024 and June 2026, we will recruit 480 eligible couples from KK Women’s and Children’s Hospital, Singapore. Male and female participants will complete questionnaires on sociodemographics, general health and lifestyle factors, and their anthropometry and body fat composition will be measured. Blood and semen samples from the male participants will be collected for biochemical, molecular and semen analyses. Predictive male factors will be identified using the least absolute shrinkage and selection operator method, accounting for female factors. We will construct a logistic regression model incorporating both male and female factors to derive a fertility index, which will be evaluated using cross-validation on subsets of the study population. Multivariable linear regression will be used to explore relationships between male modifiable exposures and semen parameters.Ethics and disseminationThe study protocol has received approval from the Centralised Institutional Review Board of SingHealth (2024/2120), Singapore. Participants will provide written informed consent. Study results will be disseminated through conferences and peer-reviewed scientific journals.Trial registration numberNCT06293235.
Patient preferences for drug therapy in inflammatory arthritis: protocol for a living systematic review and evidence map to inform clinical practice guidelines
Authors: Saadat Pakeezah , Bansback Nick , Falahee Marie , Hiligsmann Mickaël , Tugwell Peter , Buchbinder Rachelle , Whittle Samuel , Richards Dawn P , Proulx Laurie , Schunemann Holger , Alonso-Coello Pablo , Nieuwlaat Robby , Wiercioch Wojtek , Kuper Simon , Pardo Pardo Jordi , Hazlewood Glen 
Published: January 2025

IntroductionThe pharmacological management of inflammatory arthritis often requires choices that involve trade-offs between benefits, risks and other attributes such as administration route, frequency and cost. This living systematic review aims to inform international clinical guidelines on inflammatory arthritis by creating an evidence map of patient preference studies concerning the trade-offs in pharmacological management of inflammatory arthritis.Methods and analysisWe will include published and peer-reviewed full-text studies in any language that quantitatively assess preferences of patients for the pharmacological management of inflammatory arthritis (rheumatoid arthritis, spondyloarthritis and juvenile idiopathic arthritis). Studies must use either stated or revealed preference methods to assess preferences and provide a quantitative assessment of relevant characteristics, such as benefits, risks, costs and process attributes. Articles will identified through Medline and EMBASE database searches from inception using search terms that combine keywords and subject headings for inflammatory arthritis and preference-based methods, and a search in the Health Preference Study and Technology Registry using keywords for the populations of interest. Two independent reviewers will perform abstract and full-text screening. Risk of bias will be assessed using the GRADE risk of bias tool. An evidence map will be generated to summarise included studies and their assessments of each trade-off. The search will be conducted every 6 months with new studies added to the inventory.Ethics and disseminationEthics approval is not required. Results from the base review will be published in a peer-reviewed journal and findings will be presented at conferences. In the living model, we will publish updates and datasets on an Open Science Framework page, with periodic updates in peer-reviewed journals.
Development of a core patient-reported outcome set for use in HIV care at the individual patient level in Montreal: protocol for a two-phased multimethod project
Authors: Engler Kim , Lessard David , Lacombe Karine , Palich Romain , Lebouché Bertrand 
Published: January 2025

IntroductionThere is international interest in using patient-reported outcome measures in HIV care to improve the well-being of people with HIV, but the prioritisation of specific outcomes and measures remains unclear. This project’s objective is to engage both people with HIV and healthcare, social and community service providers to develop a French and English-language core set of patient-reported outcomes and measures for use in HIV care at the patient level in Montreal (Canada).Methods and analysisThis multimethod project will follow guidance from the Core Outcome Measures in Effectiveness Trials Initiative and involve two phases. Phase 1 will see the selection of the core set of outcomes (ie, the health concepts to target) and include a rapid scoping review to inform a Delphi study with a panel of 50 people with HIV and providers in Montreal. It will end with a multidisciplinary consensus meeting to make final decisions on the outcomes. Phase 2 will be devoted to choosing the measures to assess the selected outcomes. It will include a systematic search for instruments, an appraisal of the quality and feasibility of the identified instruments and a consensus meeting for the final selection.Ethics and disseminationResearch ethics board (REB) approval was obtained on 9 December 2024, from the institutional REB of the Research Institute of the McGill University Health Centre (reference number: 2024-9695). Findings will primarily be disseminated to (1) healthcare and social service providers through academic rounds and a provincial continuing education programme for HIV clinicians; (2) to people with HIV through partner community organisations and (3) a range of stakeholders at local, national and international conferences and through peer-reviewed publications.
mHealth knowledge and usage in maternal healthcare delivery: perspectives and experiences of healthcare practitioners in Ghana
Authors: Ameyaw Edward Kwabena , Amoah Padmore Adusei , Asiama Aikins Amoako , Agbadi Pascal 
Published: January 2025

ObjectivesThis study explored the knowledge and experiences of health practitioners regarding the use of mobile health (mHealth) for maternal healthcare delivery.DesignUnderpinned by the Unified Theory of Acceptance and Use of Technology, this study was an exploratory qualitative design involving in-depth interviews. Data collection occurred between July 2023 and January 2024.SettingThe study was conducted in three administrative regions in Ghana: Ashanti, Northern and Upper West regions. In each of these regions, one urban and one rural setting were selected to ascertain pertinent data from a wide range of maternity health practitioners and directors of health services operating within these regions.ParticipantsPurposive sampling technique was used to recruit 32 participants, who fall into two primary groups: directors of health services (n=9) and maternity health practitioners (23).ResultsThe findings revealed that maternal healthcare providers were familiar with and frequently used mHealth technologies (typically video calls/conferences and text messages). mHealth was considered a useful tool in maternal healthcare as it enhanced the efficiency of service delivery and improved practitioners’ performance. mHealth facilities eased access to digital medical information, user-friendly interfaces and the ability to facilitate remote consultations. The willingness and ability of health professionals to use mHealth were conditioned by the nature of organisational and infrastructural support they received, including technical guidance and equipment availability. Thus, mHealth knowledge and use among maternal healthcare providers are predicated on personal, social and institutional conditions.ConclusionsMaternal healthcare providers are generally aware of the benefits of mHealth and are ready to use it when available. Thus, it is imperative that the Government of Ghana prioritise incorporation of mHealth into the existing and future maternal healthcare model to enhance care delivery and increase the prospects of achieving the first and second targets of the third Sustainable Development Goals. To ascertain greater gains from mHealth, it is worth acknowledging the varying factors that drive the adoption and effective use of mHealth, such as performance expectancy, ease of use, social influences and organisational support. Interventions aimed at enhancing mHealth integration should address these factors in a context-specific manner.
Updating the Scottish national cardiovascular risk score: ASSIGN version 2.0
Authors: Welsh Paul , Kimenai Dorien M , Woodward Mark 
Published: January 2025

BackgroundThe Assessing cardiovascular risk using Scottish Intercollegiate Guidelines Network (ASSIGN) risk score, developed in 2006, is used in Scotland for estimating the 10-year risk of first atherosclerotic cardiovascular disease (ASCVD). Rates of ASCVD are decreasing, and an update is required. This study aimed to recalibrate ASSIGN (V.2.0) using contemporary data and to compare recalibration with other potential approaches for updating the risk score.MethodsData from Scotland-resident participants from UK Biobank (2006–2010) and the Generation Scotland Scottish Family Health Study (2006–2010), aged 40–69 and without previous ASCVD, were used for the derivation of scores. External evaluation was conducted on UK Biobank participants who were not residents of Scotland. The original ASSIGN predictor variables and weights formed the basis of the new sex-specific risk equation to predict the 10-year risk of ASCVD. Different approaches for updating ASSIGN (recalibration, rederivation and regression adjustment) were tested in the evaluation cohort.ResultsThe original ASSIGN score overestimated ASCVD risk in the evaluation cohort, with median predicted 10-year risks of 10.6% for females and 15.1% for males, compared with observed risks of 6% and 11.4%, respectively. The derivation cohort included 44 947 (57% females and a mean age of 55) participants. The recalibrated score, ASSIGN V.2.0, improved model fit in the evaluation cohort, predicting median 10-year risk of 4% for females and 8.9% for males. Similar improvements were achieved using the regression-adjusted model. Rederivation of ASSIGN using new beta coefficients offered only modest improvements in calibration and discrimination beyond simple recalibration. At the current risk threshold of20% 10-year risk, the original ASSIGN equation yielded a positive predictive value (PPV) of 16.3% and a negative predictive value (NPV) of 94.4%. Recalibrated ASSIGN V.2.0 showed similar performance at a 10% threshold, with a PPV of 16.8% and an NPV of 94.6%.ConclusionsThe recalibrated ASSIGN V.2.0 will give a more accurate estimation of contemporary ASCVD risk in Scotland.
Investigating the soft and hard limits in transverse momentum spectra in pp collisions
Authors: Bíró Gábor , Serkin Leonid , Paić Guy , Barnaföldi Gergely Gábor 
Published: January 2025

Abstract
The transverse momentum spectra and their multiplicity dependence serve as key tools for extracting parameters to be compared with theoretical models. Over the past decade, the scientific community has extensively studied the possibility of a system analogous to quark-gluon plasma, predicted in heavy nuclei collisions, also existing in collisions involving light nuclei and protons. We have reanalysed the data published by the ALICE Collaboration at the LHC. We present the dependence of the mean transverse momenta obtained in the soft and soft+hard (mixed) parts. Finally, we also discuss possible refinements of the analyses concerning the use of statistical parameters of higher order, aimed at a more detailed way of comparing the models with data.
The Strange Case of Herbert Silberer (1882–1923)
Authors: Priviero Tommaso 
Published: January 2025

Abstract
The case of the Viennese thinker and psychoanalyst Herbert Silberer represents an almost completely forgotten piece in the history of psychology and psychoanalysis. However, the connections between his work and C.G. Jung’s are striking and hitherto overlooked, despite Jung once referring to Silberer’s work as a “very important” contribution to the non-reductive interpretation of symbol-formation. Similarly involved in practices of visioning and self-experimentation around the time that Jung was engaged with the Red Book, Silberer directly contributed to Jung’s longstanding interest in alchemy and his ideas around “constructive” and teleological functions of the mind. He formulated the hypothesis of collective symbols known as “elementary types”, ahead of Jung’s own archetypal formulation. He proposed methods of analysis “beyond” dream interpretation and akin to active imagination, before Jung’s similar suggestions. Last but not least, he distanced himself from Freud’s psychoanalytic circle to pursue his own path, although, unlike Jung, he did not found an alternative psychotherapy school and eventually met with a tragic fate. This paper dissects the story of Silberer’s oblivion and recounts it through Jung’s remarkable, yet still unknown encounter with his life and work.
Politics and the Nigerian Army (1965–1966)
Authors: Omeni Akali 
Published: January 2025

Abstract
Four years after Nigeria’s Independence (1960), its army remained headed by a British General Officer Commanding (GOC). Seeking to change this in April 1965, the government’s ‘Nigerianisation’ agenda saw Major-General Aguiyi-Ironsi, an Igbo from Eastern Nigeria, appointed Army GOC by Prime Minister Balewa. Months later, in January 1966, military coupists assassinated Balewa, and Ironsi emerged as Nigeria’s first military Head of State. Whereas Ironsi’s brief but disastrous rule (January–July 1966) is well-discussed, his selection as GOC from a highly-politicised shortlist of four senior officers—and the short-term significance of that appointment—remains under-illuminated. Offering a historical corrective, I centrally relocate the Army’s ‘Nigerianisation’ and Ironsi’s appointment within the debate on ethnic politics and Nigeria’s descent into violence (1966–1967). Against this backdrop, I argue that Ironsi’s appointment was made by a cautious government seeking to preserve a precarious ethnic power balance across the Army’s ranks.
Paramedic Judgment as a Basis for Trauma Triage: Is it an Effective Strategy?
Authors: Schaefer Matthew P. , Lamy Chrisnel , Mederos-Rodriguez Dalier , Berne John D. 
Published: January 2025

Introduction American College of Surgeons-Committee on Trauma (ACS-COT) defines minimum Standard Criteria (SC) for Level 1 trauma. In our hospital, discretion of prehospital personnel (“Paramedic Judgment” [PJ]) can initiate Full Trauma Triage Activation (FTTA) in the absence of ACS-COT criteria. The aim of this study was to evaluate overtriage and undertriage for PJ vs SC. Methods 1846 patients met criteria from 1/1/19 to 1/5/23. This study utilized the Cribari Matrix to define under, over, and appropriate triage, and utilizes Chi-Squared Test to determine significance. We performed an adjusted binomial logistic regression comparing overtriage and undertriage for PJ vs SC. We analyzed the Need for Emergent Intervention-6 (NEI-6) model to see if it could be a way to accurately assess triage. Results Overtriage for the PJ group was 68.9%, compared to 54.8% for SC, with a P-value ≤.05, and undertriage for the PJ group was 1.23% compared to 0.13%. After adjusting for confounders, the risk of overtriage by the PJ group was 2.04 times as likely compared to the SC group (OR 2.04; P < .01). The OR for undertriage was not calculated due to lack of power. The odds of needing a blood transfusion for the PJ patients compared to the SC patients is approximately one-third (OR 0.33; P < .01). The other variables were lacking in power. Conclusion The aim of this study is to evaluate over and undertriage for PJ and SC at our large urban center. We found that overtriage was 2 times as likely when using PJ compared with the SC.
Emerging therapies in Multiple Myeloma: Leveraging immune checkpoint inhibitors for improved outcomes
Authors: Mandavkar Anuja Anil , Padakanti Suraj Sai Nikhil , Gupta Srajan , Akram Samiyah , Jaffar Nida , Chauhan Jugalkishor , Allu Likhita Reddy , Saini Pulkit , Nasrallah Jamil , Omar Mohamed Abdullahi , Mugibel Muna Ali , Syed Saif , Ravindran Kumaran Ottilingam , Dwivedi Ayush , Dhingra Gurneet Singh , Dhingra Avleen , Kakadiya Jay , Kotaich Jana , Beniwal Shreya Singh 
Published: January 2025

Background:  Multiple Myeloma is a hematological malignancy characterized by the proliferation of clonal plasma cells and associated with severe clinical manifestations. Despite advancements in diagnosis and management, Multiple Myeloma remains incurable, necessitating further research into more effective therapies. Aim:  The primary objective of this review is to provide an informative and critical summary of the Multiple Myeloma microenvironment, and emerging revolutionary therapeutic approaches with potential combination therapy to improve the quality of life for Multiple Myeloma patients. Emerging approaches:  Recent advancements in immunotherapy, particularly immune checkpoint inhibitors (ICIs), have shown improvements in immune response against Multiple Myeloma. ICIs target inhibitory pathways such as PD-1/PD-L1 and CTLA-4, potentially overcoming tumor-induced immunosuppression. Combination therapies integrate ICIs with proteasome inhibitors, immunomodulators, and monoclonal antibodies to enhance the anti-tumor immune response. Additionally, Chimeric Antigen Receptor T-cell (CAR-T) therapy has demonstrated effectiveness against Multiple Myeloma, particularly when coupled with ICIs to decrease resistance and relapse. Challenges:  Although the efficacy of ICIs in treating Multiple Myeloma has been hindered by the complexity of the tumor microenvironment and immune evasion mechanisms, this challenge has led to the exploration of combination therapies. Potential side effects are still a big challenge for newly recognized ICIs and combination treatment. Future directions:  Investigations of new immune checkpoints and the development of targeted therapies against these markers are in progress, creating possibilities for more personalized and effective treatment strategies. Continuous research and robust clinical trials are needed to comprehend the complex dynamics of the Multiple Myeloma microenvironment to develop revolutionary therapeutic targets.