bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Movement Disorders Commonly Seen in Asians
Authors: Jagota Priya , Lim Shen‐Yang , Pal Pramod Kumar , Lee Jee‐Young , Kukkle Prashanth Lingappa , Fujioka Shinsuke , Shang Huifang , Phokaewvarangkul Onanong , Bhidayasiri Roongroj , Mohamed Ibrahim Norlinah , Ugawa Yoshikazu , Aldaajani Zakiyah , Jeon Beomseok , Diesta Cid , Shambetova Cholpon , Lin Chin‐Hsien 
Published: April 2023

AbstractThe increasing availability of molecular genetic testing has changed the landscape of both genetic research and clinical practice. Not only is the pace of discovery of novel disease‐causing genes accelerating but also the phenotypic spectra associated with previously known genes are expanding. These advancements lead to the awareness that some genetic movement disorders may cluster in certain ethnic populations and genetic pleiotropy may result in unique clinical presentations in specific ethnic groups. Thus, the characteristics, genetics and risk factors of movement disorders may differ between populations. Recognition of a particular clinical phenotype, combined with information about the ethnic origin of patients could lead to early and correct diagnosis and assist the development of future personalized medicine for patients with these disorders. Here, the Movement Disorders in Asia Task Force sought to review genetic movement disorders that are commonly seen in Asia, including Wilson's disease, spinocerebellar ataxias (SCA) types 12, 31, and 36, Gerstmann‐Sträussler‐Scheinker disease, PLA2G6‐related parkinsonism, adult‐onset neuronal intranuclear inclusion disease (NIID), and paroxysmal kinesigenic dyskinesia. We also review common disorders seen worldwide with specific mutations or presentations that occur frequently in Asians.
Complementarity on software as a service platform
Authors: Loginova Oksana , Wang X. Henry 
Published: April 2023

AbstractA platform owner offers product A. A third‐party firm develops a complementary product B: An additional value is created when the two products are consumed together. Access to the platform owner's customer base would broaden the third‐party firm's market reach. First, the third‐party firm chooses the quality of its product. Then, the platform owner and the third‐party firm simultaneously set their prices. We find that a higher level of product complementarity gives the third‐party firm an incentive to raise its quality; however, access to the platform may result in either a higher or a lower quality.
Uncertainty propagation of soil property in dynamic site response under different site conditions
Authors: Liu Wenxin , Chen Qiushi , Juang Charng Hsein , Chen Guoxing 
Published: April 2023

AbstractIt has been recognized that the soil profile and the associated parameters are usually not known with certainty in probabilistic seismic hazard analysis, however, little is known about the influence of site conditions on the propagation of uncertainty. This work aims to analyze and quantify the propagation of soil property uncertainties in site response analysis under different site conditions using a recently proposed DCZ constitutive model. Sensitivity analysis is performed to determine the most important parameter, which is regarded as a random variable in the subsequent uncertainty analysis. A Monte Carlo simulation procedure is applied to quantify the uncertainty propagation caused by the random variable. Detailed case studies involving multiple site conditions are presented to quantify the impacts of soil property variability under different site conditions in site responses. This study has found that variation in site response strongly depends on the shear wave velocity compared to other parameters. For softer soil, the PGA values at the ground surface show more dispersion (i.e., uncertainties) compared to stiffer soil. This indicates that for improving the accuracy of site response analysis and earthquake disaster prediction, it is necessary to operate probabilistic dynamic site response analysis rather than deterministic analysis, especially for soft soil.
Effect of silver nanoparticles on structural, thermal, electrical, and mechanical properties of poly(vinyl alcohol) polymer nanocomposites
Authors: Kareem Aseel A. , Polu Anji Reddy , Rasheed Hussein Kh. , Alomayri Thamer 
Published: April 2023

AbstractThis paper presents the in‐situ chemical synthesis of silver nanoparticles (AgNPs) with glycerol embedded in poly(vinyl alcohol) (PVA) to synthesize (PVA/AgNPs) polymer nanocomposites with different volume percentages of AgNPs (2, 4, and 6) %v/v. X‐ray diffractometer shows the (200) plane of AgNPs, which appeared at 44.82° in PVA/(2, 4, and 6) %v/v AgNPs films. However, the (111), (220), and (311) planes at 2θ (37.55°, 65.08°, and 77.45°) respectively appeared in PVA with 6%v/v AgNPs only. Fourier transform infrared spectroscopy spectrum of AgNPs shows a COC peak at 1273 cm−1 which is attributed to the stronger affinity of AgNPs on the COC bonds in the PVA matrix. The scanning electron microscope confirmed that all nanoparticles are open‐spherical or near‐spherical in shape. Differential scanning calorimetry shows the decrease in glass transition and melting temperature of pure PVA from 64.62° and 185.54° to 53.09° and 182.35° after the incorporation of AgNPs. Thermogravimetric analysis shows the reduction of thermal stability of PVA/AgNPs films when compared to pure PVA. The electrical conductivity of PVA/AgNPs films increased with the addition of AgNPs. From Mechanical studies, the values of Young's modulus, yield strength, and ultimate tensile strength decreased with increasing AgNPs volume percentage.
Precision marking of glass with excimer lasers
Authors: Meinertz Jörg , Richter Lukas Janos , Beckmann Clemens M. , Ihlemann Jürgen 
Published: April 2023

AbstractCurrent laser marking of glass by CO2 lasers is mainly based on the generation of cracks or melt pits. Improved quality in the form of damage free, high contrast, and high resolution marking is possible by using deep ultraviolet emitting excimer lasers. Various methods of ablative microstructure formation or nanoparticle implantation are available to achieve colored marks on glass formed by opalescence, chemical modification, or plasmonic absorption.
The role of serum lipids and BMI in China patients with primary pterygium
Authors: Sun Yu‐ying , Liang Wei‐peng , Zeng Ya‐ting , Luo Shu‐ai , Huang Chun‐yu , Liu Yu‐ying 
Published: April 2023

AbstractTo study the role of Body Mass Index (BMI) and serum lipid profile molecules, as well as their derivative indexes in primary pterygium patients. The patient group consisted of 110 patients with primary pterygium diagnosed in our center between January 2019 and December 2020, while the control group consisted of 144 healthy persons of similar age and sex diagnosed during the same time period. The BMI, serum lipid profile molecules and their derivative indexes of both groups were analyzed retrospectively. In the patient group, 62 patients were overweight or obesity and 104 patients with dyslipidemia. Among them, body mass index (BMI), serum triglycerides (TG), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (Apo‐B) levels were significantly higher than those in the control group (p < 0.05). The difference in Apo‐B/ApoAl ratio, TC/LDL‐C ratio, HDL‐C/LDL‐C ratio was statistically significant (p < 0 .05), while the serum high‐density lipoprotein cholesterol (HDL‐C), apolipoprotein A1 (ApoA1) and TG/LDL‐C ratio were not significantly different in the patient group compared with control group (p > 0.05). Logistic analysis indicated that obesity, TC and HDL‐C/LDL‐C ratio are independent risk factors influencing the onset of pterygium (p < .05). BMI and serum lipid level are both significantly associated with primary pterygium. Obesity and abnormal serum lipid metabolism are independent risk factors for pterygium and play a critical role in the development of pterygium. Obesity and serum lipid level can significantly affect clinical management of pterygium. These characteristics are simple to use in clinical practice and may aid in the identification of pterygium high‐risk populations.
Distributed fault‐tolerant control for over‐actuated multi‐agent systems with uncertain perturbations using control allocation
Authors: Du Yanbin , Jiang Bin , Ma Yajie 
Published: April 2023

AbstractThis paper proposes a distributed fault‐tolerant control for over‐actuated multi‐agent systems with uncertain perturbations and faults including partial loss of effectiveness or even complete failures. The entire distributed control law is divided into two parts that are the distributed observer and the decentralised controller with a hierarchical structure. The adaptive distributed observer estimates not only the leader's state, but also the leader's system matrix, which makes the whole distributed design more rigorous. For each over‐actuated subsystem, the control allocation based hierarchical control structure is used. The virtual control is developed based on adaptive optimal control approaches to cope with uncertain perturbations robustly. The model reference adaptive control is used to design the control allocator without the need for the fault detection and diagnosis module. The stability and robustness of the systems are rigorously demonstrated, and the feasibility and effectiveness of the control law are verified in simulations on the attitude dynamics system of spacecraft.
Changes to the trophic structure of a desert fish community following river regulation and species turnover: Implications for an endangered top predator
Authors: Gilbert Eliza I. , Franssen Nathan R. 
Published: April 2023

AbstractA poor understanding of factors leading to species decline can result in inefficient or ineffective species restoration. Endangered Colorado pikeminnow (Ptychocheilus lucius) was nearly extirpated from the San Juan River, NM, USA and recent efforts to reestablish the species via hatchery augmentation of juveniles has yet to reach the target number of adults in the system. To assess how changes to the river's food web could be limiting reestablishment of this top predator, we used stable isotope (δ13C and δ15N) signatures of the fish community pre‐ (museum specimens) and post river regulation with coincident extirpations and invasions. Following river regulation, four of five community‐wide trophic structure metrics that quantify overall resource use were reduced and species turnover likely had little effect per se. For species sampled in both time periods, shared trophic resources generally increased (mean niche overlap = +35.7%). Additionally, Colorado pikeminnow experienced the largest decrease in niche breadth (−72%) and diet mixing models suggested a shift from piscivory towards insectivory in contemporary collections. Our results suggest an overall reduction in basal resource availability after river regulation. We propose increased reliance on similar resources may be limiting fish prey for Colorado pikeminnow, ultimately contributing to the slow and limited reestablishment in the San Juan River. This study adds to the growing body of knowledge provided by museum specimens and stable isotope analyses to identify food‐web dynamics that are a departure from historical conditions, which can provide novel information critical to imperiled species management in modified systems.
“You can't thrive when you are being suffocated”: Quantitative and qualitative findings on minority stress in Kenyan queer womxn and trans men
Authors: Haase Stephanie , Zweigenthal Virginia , Müller Alex 
Published: April 2023

AbstractMinority stress can negatively affect sexual and gender minorities' health and well‐being. Little is known about how the factors associated with minority stress influence the lived experiences of sexual and gender minorities in settings where stigma and discrimination are highly prevalent, and the legal context is restrictive.We conducted an online survey among 335 Kenyan queer womxn and trans men collecting data on internalized homophobia, outness, and LGBT shame and pride and supplemented these with 33 interviews among three stakeholder groups.We found that our sample showed overall lower levels of outness, higher levels of shame, and higher levels of internalized homophobia compared to sexual and gender minorities in other studies. Our qualitative data showed that queer womxn and trans men lack a sense of belonging and frequently face violence from various perpetrators.Understanding how minority stress affects the lived experiences of queer womxn and trans men in any context is important to advance mental health and well‐being; it is even more crucial in contexts that restrict the thriving of minorities through legislation, religion, and culture. Advancing the knowledge on minority stress is essential to address the challenges minorities face in these settings.
CO2 Capture and Separation by Mono‐Vacancy Doped Graphene in Electric Field: A DFT study
Authors: Wang Yi , Wang Huhu , Zhang Na , Wang Danqi , Wang Ruicong , Peng Wencai , Zhang Jianshu , Liu Jichang , Zhang Jinli 
Published: April 2023

AbstractIn order to reduce the CO2 content of gas pollution, it is necessary to develop more efficient, controllable and sensitive adsorption materials. In this work, the capture of CO2 by 3N‐M‐VG (3N doped mono‐vacancy graphene) nanosheets in the electric field of 0.000–0.040 a. u. were investigated by density functional theory (DFT) simulations. The interaction between CO2 and 3N‐M‐VG increased with increasing applied electric field and the adsorption of CO2 by 3N‐M‐VG underwent a transition from physical to chemisorption at electric field strengths of 0.020–0.030 a. u. In addition, the material allows the capture and release of CO2 by switching on and off an applied electric field. CO2 adsorption and selectivity of 3N‐M‐VG in CH4/H2/CO2 gas mixtures can be greatly improved by applying an electric field. Theoretical results of this study can provide guidance for the design of highly selective CO2 capture materials.
Mechanism of Cycloisomerization of 15‐Membered Triazaenediynes Macrocycle: A DFT Study
Authors: Movahedi Mansooreh , Zabarjad Shiraz Nader , Ezabadi Ali , Samadizadeh Marjaneh , Talei Bavil Olyai Mohamad Reza 
Published: April 2023

AbstractDFT calculations at M062X/6‐31+G(d,p) and M062X/Def2SVP levels of theory were utilized to explore the mechanism and cycloisomerization of 15‐membered triazaenediyne macrocycles in gas phase and Toluene. Trans triazaenediyne conducted concerted reactions to produce a trans diastereoselective tetracyclic fused structure passing through key cascade reactions starting by an Ene reaction that produced an allene intermediate (ΔG#=37.37 kcal/mol), and following a Diels‐Alder reaction which converted to trans‐tetracyclic ring overcoming a 34.10 kcal/mol barrier. In catalytic Rh (I), two steps reactions converted reagent to a diastereoselective trans‐cyclohexadiene tetracyclic by vanquishing barriers of 30.75 and 22.66 kcal/mol.
Salicylic Acid: Synthetic Strategies and Their Biological Activities
Authors: Rosheen  , Sharma Shivali , Utreja Divya 
Published: April 2023

AbstractPhenolic acids are the phytochemicals formthe key part of the organic chemistry and are widely found in the plants, plant foods and human metabolites possessing a wide range of biological activities like anti‐oxidant, anti‐bacterial, anti‐inflammatory, anti‐carcinogenic activities. Owing to their pharmaceutical activities, they are known for their different roles in prevention of various diseases in plants and as well as humans. Although a number of biologically active compounds are known in literature but unfortunately due to their cost, non‐availability and toxicity, there is an urgent need to develop such bioactive agents which can overcome all the shortcomings of reported agents. Salicylic acid is one of the hydroxybenzoic acid that is well known for possessing antimicrobial, anti‐inflammatory, anti‐cancer,anti‐tumor, anti‐proliferative, anti‐viral and analgesic properties. This review mainly outlines the synthesis and biological activities of various salicylic acid derivatives which provides guidance to the researchers working in this field for improving their activity by modification of already reported drugs.
Optical and Electrochemical Sensing of Co(II), Ni(II) and Cu(II) in DMSO. Pyridyl Thiazole and (Thio)Amide Pincer Ligands versus Di‐2‐pyridyl Ketone Hydrazones
Authors: Wilson Kirk , Wilson Kerrie‐Ann , Thompson Crystal , Lawrence Mark A. W. 
Published: April 2023

AbstractThe ability of six pincer type molecules (di‐2‐pyridyl ketone acetic acid hydrazone (1), N‐(2,5‐dimethoxyphenyl)‐6‐[(2,5‐dimethoxyphenyl)carbamothioyl]pyridine‐2‐carboxamide (2), 6‐(4,7‐dimethoxy‐2‐benzothiazolyl)‐N‐(2,5‐dimethoxyphenyl)‐2‐pyridinecarboxamide (3), di‐2‐pyridyl ketone thiosemicarbazone (4), bis‐N‐(2,5‐dimethoxyphenyl)pyridine‐2,6‐dicarbothioamide (5), and 6‐(4,7‐dimethoxy‐2‐benzothiazolyl)‐N‐(2,5‐dimethoxyphenyl)‐2‐pyridinecarbothioamide (6)), to detect MBr2 (where M=Co, Ni, and Cu) in DMSO was quantified via formation constants determined from spectrophotometric and voltammetric titrations. The limit of detection (from electronic spectroscopy) of 1–6 ranged from 0.9‐9.5 ppm. The values of β (=log K) for the six species were found to be in the ranges of 4.3–4.9 and 4.0–6.3 for Co(II), 3.9–5.5 and 3.5–4.3 for Ni(II), and 4.0–4.3 and 3.7–5.0 for Cu(II) by UV‐visible and voltammetric methods, respectively. The results suggested that κ3‐NNS (6) and the κ3‐NNO (3) had good affinity for Ni(II) and Cu(II), whereas the κ3‐SNS (5) had greater affinities for Co(II) and Ni(II). The hydrazones (κ3‐NNO, 1 and κ3‐NNS, 4) were generally in the middle of the pack, displaying good affinity for the three metal ions. In a contrasting vein, the κ3‐ONS species (2) was generally the lowest across the pincers. DFT calculations (PBE0/6‐31G(d,p)/SMD) suggested that stable complexes of coordination numbers=4 to 6 were plausible in solution.
Regulation of Wnt Signaling Pathway by Costic Acid Derivative, An Efficient Strategy for Treatment of Glucocorticoid‐Induced Osteoporosis in Rat Model
Authors: Jiang Xue , Kong Xiangying 
Published: April 2023

AbstractOsteoporosis leads to a decrease in bone mass, loss of mechanical strength, increase in fracture susceptibility and is a serious medical problem worldwide. The present study investigated the effect of costic acid derivative (CA) on dexamethasone (DXM)‐induced osteoporosis in vitro in osteoblasts and in vivo in rat a model. The results demonstrated that DXM‐mediated reduction in osteoblast viability was effectively prevented by CA treatment in dose‐dependent manner. The DXM‐induced loss of osteoblast viability was completely reversed by CA treatment at 4 μM dose. Treatment of the primary osteoblasts with 0. 5 and 4 μM CD for 72 h reversed DXM‐mediated reduction in ALP activity. The CA treatment significantly (P>0.05) reversed DXM‐mediated lowering of osteoclacin, collagen type‐1 and osteonectin mRNA expression. The CA treatment at 1.5, 3 and 6 mg/kg doses significantly (P>0.05) reversed DXM‐mediated decrease in BMD in rat femurs. Treatment of the rats with CA reversed DXM‐mediated changes in osteocalcin and CTX levels in serum samples. Administration of CA to the rats reversed DXM‐mediated decrease in Wnt, β‐catenin expression and increase in SOST and Dickkopf‐1 level. Docking studies showed that CA interacts with mammalian Wnt‐frizzled complex (6AHY) through conventional H‐bonding. Thus, CA inhibits DXM‐induced dysfunction of osteoblast differentiation in vitro and inhibits osteoporosis development in vivo in rat model. Therefore, CA may be developed as a potential therapeutic agent for treatment of bone damage induced by glucocorticoid (GC)‐mediated osteoporosis.
Catalyst‐/Additive‐Free One‐Pot Synthesis of Oxazolidines in Water via Regioselective and Stereoselective C−H Functionalization Approach
Authors: Rahman Iftakur , Baruah Biswajita , Rajbongshi Basanta K. , Deb Mohit L. , Baruah Pranjal K. 
Published: April 2023

AbstractA catalyst‐free approach for the synthesis of oxazolidine derivatives is developed here. Though the synthesized oxazolidines contain three stereogenic centers, single diastereomer of the product is obtained. Single crystal X‐ray analysis of the product confirmed the stereochemistry. The reaction is performed by taking tetrahydroisoquinoline/cyclic benzylic amine (1 equivalent) and aromatic aldehyde (2 equivalent) in water under refluxing condition which produces excellent yield (87–96 %). With pyrrolidine as amine substrate, the reaction gives α,β‐unsaturated cyclic imines which is an example of β‐C−H functionalization of secondary amine. The proposed mechanism shows that the reaction proceeds through the formation of azomethine ylide which undergoes [3+2]‐cycloaddition reaction providing the oxazolidine product.
Urease Inhibition and Structure‐Activity Relationship Study of Thiazolidinone‐, Triazole‐, and Benzothiazole‐Based Heterocyclic Derivatives: A Focus Review
Authors: Singh Rahul , Kumar Parvin , Devi Meena , Sindhu Jayant , Kumar Ashwani , Lal Sohan , Singh Devender , Kumar Harish , Kumar Sumit 
Published: April 2023

AbstractUrease has a long and distinguished history in the development of enzymology since it was the first enzyme crystallized by Sumner in 1926. The present review article is focused on the urease inhibitory potential of thiazolidinone, triazole, and benzothiazole‐based heterocyclic derivatives. The study begins with the historical developments in the discovery of urease and its substrate, urea, along with the active site architecture of ureases of different origins. The two pathways for the urease‐catalyzed hydrolysis of urea are explained in detail. The urease inhibitory potential of the aforementioned heterocyclic derivatives is reviewed and arranged systematically. Structure‐activity relationships (SARs) study provided the substituents necessary for urease inhibition and will be useful for the researchers working in the field of anti‐ulcer agents. To a step further, important binding interactions were identified with the amino acid residues at the active site of the enzyme. The information gathered is anticipated to offer logical direction and an effective method for creating innovative, potent, and efficient urease inhibitors that will have greater practical uses in the future.
Synthesis and Characterization of New N‐Pyrazol‐5‐yl) amidine Derivatives: X‐Ray Structure Hirshfeld Surface, and DFT Analyses together with Antibacterial and Antifungal Activity Studies
Authors: Louiz Sonia , Lahbib Karima , Abderrahim Raoudha 
Published: April 2023

AbstractWe present in this work, the synthesis and characterization of N‐3‐pyrazolyl amidines derivatives obtained in satisfactory yields via one‐pot reaction. New structures of amidines were confirmed by FTIR, 1H NMR, 13C NMR, 13C NMR Dept spectrum and X ray crystallography of N‐benzyl‐N‐(3‐methyl‐1H‐pyrazol‐5‐yl) propanimidamide. In order to determinate the configuration of this amidine we have characterized it using also HRMS, DSC to determine the fusion points, X‐ray crystallography and Hirshfeld Surface analysis. The grown crystal possesses a dielectric behavior and DFT Calculation which has shown linear correlation between theoretical and experimental Hydrogen bond geometry, bond lengths (A°) and Torsion angles of 1 a. The examination of the spectrum and the SEM diagram of amidine 1a allowed us to determine the size of the particles which is of the order of 1.8 μm.All new amidines were screened for their antibacterial and antifungal activities and their phenotypic analysis was performed using the Phenotype Micro Arrays (PMs) tool to determine cellular responses during their respiration process.Amidines had relatively antibacterial activities with an antifungal behavior proving their interface reaction with several microrganisms. Such finding can be useful in medical and agricultural fields. The considered species belong to human's gut flora and soil phytopathogenesis fungi.