bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence of sex differences in cancer‐related cardiac complications in mouse models of pancreatic and liver cancer
Authors: Gams Anna , Nevarez Alejandro , Perkail Stephanie , Venegas Aileen , George Sharon A. , Efimova Tatiana , Efimov Igor R. 
Published: April 2023

AbstractAbnormal heart rate variability (HRV) is commonly observed in cancer patients who have undergone targeted therapy and/or surgery, yet the effects of cancer itself on cardiac function remain underexplored. Specifically, there is limited knowledge about sex‐specific manifestations of HRV in cancer patients. Transgenic mouse models are widely used to study different types of cancer. Here, we aimed to investigate the sex‐specific effects of cancer on cardiac function using transgenic mouse models of pancreatic and liver cancers. This study used male and female transgenic mice with cancer and wild‐type controls. Cardiac function was assessed by recording electrocardiograms in conscious mice. RR intervals were detected to determine HRV using time and frequency domain analyses. Histological analysis with Masson's trichrome staining was performed to determine structural changes. In females, increased HRV was observed in both pancreatic and liver cancer‐bearing mice. In contrast, in males, increased HRV was observed only in the liver cancer group. Male pancreatic cancer mice demonstrated autonomic balance shift showing an increase in parasympathetic to sympathetic tone. The heart rate (HR) was higher in control and liver cancer male mice groups than in females. Histological analysis did not show significant sex differences but suggested a higher degree of remodeling in liver cancer mice than in control, specifically in the right atrium and left ventricle. This study revealed sex differences in cancer's HR modulation. Specifically, female cancer mice had lower median HR and higher HRV. These findings indicate that sex must be considered when using HRV as a cancer biomarker.
Resistance exercise acutely elevates dynamic cerebral autoregulation gain
Authors: Smail Oliver J. , Clarke Daniel J. , Al‐Alem Qais , Wallis William , Barker Alan R. , Smirl Jonathan D. , Bond Bert 
Published: April 2023

AbstractDynamic cerebral autoregulation (dCA) describes the regulation of cerebral blood flow (CBF) in response to fluctuations in systemic blood pressure (BP). Heavy resistance exercise is known to induce large transient elevations in BP, which are translated into perturbations of CBF, and may alter dCA in the immediate aftermath. This study aimed to better quantify the time course of any acute alterations in dCA after resistance exercise. Following familiarisation to all procedures, 22 (14 male) healthy young adults (22 ± 2 years) completed an experimental trial and resting control trial, in a counterbalanced order. Repeated squat‐stand manoeuvres (SSM) at 0.05 and 0.10 Hz were used to quantify dCA before, and 10 and 45 min after four sets of ten repetition back squats at 70% of one repetition maximum, or time matched seated rest (control). Diastolic, mean and systolic dCA were quantified by transfer function analysis of BP (finger plethysmography) and middle cerebral artery blood velocity (transcranial Doppler ultrasound). Mean gain (p = 0.02;d = 0.36) systolic gain (p = 0.01;d = 0.55), mean normalised gain (p = 0.02;d = 0.28) and systolic normalised gain (p = 0.01;d = 0.67) were significantly elevated above baseline during 0.10 Hz SSM 10‐min post resistance exercise. This alteration was not present 45 min post‐exercise, and dCA indices were never altered during SSM at 0.05 Hz. dCA metrics were acutely altered 10 min post resistance exercise at the 0.10 Hz frequency only, which indicate changes in the sympathetic regulation of CBF. These alterations recovered 45 min post‐exercise.
Transl[iter]ating Dubai’s linguistic landscape: a bilingual translation perspective between English and Arabic against a backdrop of globalisation
Authors: Gu Chonglong , Almanna Ali 
Published: April 2023

Abstract
As a burgeoning area of interdisciplinary enquiry, linguistic landscape (LL) research can shed light on the sociopolitical, cultural and demographical realities of a particular locale. However, LL research has seldom explored major international cities from a translation and contrastive perspective. Drawing on a corpus containing 450 photographs (e.g. shop fronts and public signs), this study investigates the multilingual landscape involving the Arabic-English pair in Dubai, an international hub representing a vivid case of micro-cosmopolitanism and superdiversity in the 21st century. An examination of the bilingual and translation practices enacted on Dubai’s LL points to a ubiquitous phenomenon that the Arabic information is often not authentic Arabic but transliterations from English (pseudo Arabic in disguise). Such use of transliteration privileges the phonetic transference of sounds, at the expense of meaning and function. The prevalent use of transliteration as a ‘go-to’ strategy is interesting, considering the obvious existence of pure Arabic equivalents. To provide some ethnographic context for the analysis, 10 people in Dubai were interviewed (Arabic speakers from different Arab countries) to establish whether the transliterated Arabic can be understood and the possible rationale behind this interesting linguistic decision. Such symbolic and decorative use of Arabic reflects Dubai’s global city status with immigrants significantly outnumbering the indigenous Arabic-speaking natives. The widespread aesthetic use of ‘Arabised English’ points to the influence of English in a globalised world. Some tentative reasons are provided to explain the phenomenon.
Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans
Authors: Gómez‐Escribano Ana P , Mora‐Martínez Carlos , Roca Marta , Walker Denise S , Panadero Joaquín , Sequedo Maria D , Saini Ratni , Knölker Hans‐Joachim , Blanca Jose , Burguera Juan , Lahoz Agustin , Cañizares Joaquin , Millán José M , Burton Nick O , Schafer William R , Vázquez‐Manrique Rafael P 
Published: April 2023

AbstractAlzheimer's, Parkinson's and Huntington's diseases can be caused by mutations that enhance protein aggregation, but we still do not know enough about the molecular players of these pathways to develop treatments for these devastating diseases. Here, we screen for mutations that might enhance aggregation in Caenorhabditis elegans, to investigate the mechanisms that protect against dysregulated homeostasis. We report that the stomatin homologue UNC‐1 activates neurohormonal signalling from the sulfotransferase SSU‐1 in ASJ sensory/endocrine neurons. A putative hormone, produced in ASJ, targets the nuclear receptor NHR‐1, which acts cell autonomously in the muscles to modulate polyglutamine repeat (polyQ) aggregation. A second nuclear receptor, DAF‐12, functions oppositely to NHR‐1 to maintain protein homeostasis. Transcriptomics analyses of unc‐1 mutants revealed changes in the expression of genes involved in fat metabolism, suggesting that fat metabolism changes, controlled by neurohormonal signalling, contribute to protein homeostasis. Furthermore, the enzymes involved in the identified signalling pathway are potential targets for treating neurodegenerative diseases caused by disrupted protein homeostasis.
Environmental Protection in the Job Creation Law
Authors: Muslim Reyhandhi Alfian , Najicha Fatma Ulfatun 
Published: April 2023

On October 5, 2020, the Indonesian government passed the Omnimbus Law which contained various kinds of legislation. Including the environment which is also regulated in the Omnimbus Law. On the one hand, this regulation provides hope for Indonesia's economic growth. However, on the other hand, this regulation has the potential to damage the environment and is not in line with the Indonesian Government's commitment to reduce greenhouse gas (GHG) emissions, which in it weakens instruments for environmental protection and management. Weakening of environmental instruments has the potential to increase greenhouse gas emissions through high-carbon activities and investment in fossil energy. Therefore, this paper will critically analyze how the weakening of environmental instruments in the Omnimbus Law and the Revision of the Minerba Law hampers the fulfillment of Indonesia's greenhouse gas emission reduction targets in the era of restoring national economic stability.
Keywords: Environmental Protection Instruments, National Economic Recovery, Omnimbus Law, Greenhouse Gas Emissions.
Food-induced cortisol secretion is comparable in lean and obese male subjects
Authors: Arroyo Tardio Patricia , Baldini Gabriela , Seelig Eleonora 
Published: April 2023

Objective
Hypercortisolism is a risk factor for obesity. Cortisol increases in response to food intake in lean subjects. In obese subjects, disturbances of the food-induced cortisol peak were reported, but data from sufficiently powered and well-controlled trials are lacking. Understanding the cortisol response to food is essential as amplified or recurrent cortisol surges could lead to hypercortisolism and contribute to obesity. Therefore, we investigate the cortisol response to food in lean and obese subjects.

Design
This is a non-randomized, open-label study.

Methods
We assessed serum cortisol values after a high-calorie meal in lean and obese male subjects. Cortisol levels were frequently assessed before and for 3 h after food intake.

Results
A total of 36 subjects (18 lean and 18 obese) were included. There was no difference in overall cortisol levels between both groups during the study (area under the curve (AUC) obese: 55,409 ± 16,994, lean: 60,334 ± 18,001, P = 0.4). Total cortisol levels reached peak concentrations 20 min after food intake in both groups; the maximum cortisol increase was similar in both groups (cortisol increase obese: 69.6 ± 135.5 nmol/L, lean: 134.7 ± 99.7 nmol/L; P = 0.1). There was no correlation between body mass index and baseline cortisol values (R2 = 0.001, P = 0.83), cortisol increase (R2 = 0.05, P = 0.17), or cortisol AUC (R2 = 0.03, P = 0.28).

Conclusions
This study demonstrates that high-calorie food intake causes an immediate and substantial cortisol response in lean and obese subjects and is independent of body weight.

Significance statement
This study demonstrates that high-calorie food intake causes an immediate and substantial cortisol response in lean and obese subjects, independent of body weight. In contrast to the current literature, our findings show that the physiological cortisol response to food is intact in obesity. The substantial and prolonged increase further supports the hypothesis that frequent high-calorie meals cause hypercortisolism and aggravate weight gain.
Preventing extreme events in the urban environment using blue–Green infrastructure
Authors: Raczková Andrea , Wittmanová Réka , Hrudka Jaroslav , Škultétyová Ivona 
Published: April 2023

AbstractThe presented paper draws attention to the need to adapt urban areas to the negative impacts of climate change, more precisely to the solution of extreme rainfalls and long dry periods. The topic of rainwater management is popular worldwide due to the worsening situation in the field of climate change. Extreme weather fluctuations and torrential rains stress the urban hydrological cycle. Adaptation measures are proposed that mitigate the impact of climate change in cities. These also include measures to retain water in the country. The paper focuses on drainage density analysis, runoff coefficients and impermeability analysis, and the selection of appropriate measures to reduce surface runoff.
An Adaptable Optimal Network Topology Model for Efficient Data Centre Design in Storage Area Networks
Authors: Rajan Sanju , Joseph Linda 
Published: April 2023

In this research, we look at how different network topologies affect the energy consumption of modular data centre (DC) setups. We use a combined-input directed approach to assess the benefits of rack-scale and pod-scale fragmentation across a variety of electrical, optoelectronic, and composite network architectures in comparison to a conventional DC. When the optical transport architecture is implemented and the appropriate resource components are distributed, the findings reveal fragmentation at the layer level is adequate, even compared to a pod-scale DC. Composable DCs can operate at peak efficiency because of the optical network topology. Logical separation of conventional DC servers across an optical network architecture is also investigated in this article. When compared to physical decentralisation at the rack size, logical decomposition of data centers inside each rack offers a small decrease in the overall DC energy usage thanks to better resource needs allocation. This allows for a flexible, composable architecture that can accommodate performance based in-memory applications. Moreover, we look at the state of fundamentalmodel and its use in both static and dynamic data centres. According to our findings, typical DCs become more energy efficient when workload modularity increases, although excessive resource use still exists. By enabling optimal resource use and energy savings, disaggregation and micro-services were able to reduce the typical DC's up to 30%. Furthermore, we offer a heuristic to duplicate the Mixed integer model's output trends for energy-efficient allocation of caseloads in modularized DCs.
An Imperceptible Method to Monitor Human Activity by Using Sensor Data with CNN and Bi-directional LSTM
Authors: Rajesh P. , Kavitha R. 
Published: April 2023

Deep learning (DL) algorithms have substantially increased research in recognizing day-to-day human activities All methods for recognizing human activities that are found through DL methods will only be useful if they work better in real-time applications. Activities of elderly people need to be monitored to detect any abnormalities in their health and to suggest healthy life style based on their day to day activities. Most of the existing approaches used videos, static photographs for recognizing the activities. Those methods make the individual to feel anxious that they are being monitored. To address this limitation we utilized the cognitive outcomes of DL algorithms and used sensor data as input to the proposed model which is collected from smart home dataset for recognizing elderly people activity, without any interference in their privacy. At early stages human activities the input for human activity recognition by DL models are done using single sensor data which are static and lack in recognizing dynamic and multi sensor data. We propose a DL architecture based on the blend of deep Convolutional Neural Network (CNN) and Bi-directional Long Short-Term Memory (Bi-LSTM) in this research which replaces human intervention by automatically extracting features from multifunctional sensing devices to reliably recognize the activities. During the entire investigation process we utilized Tulum, a benchmark dataset that contains the logs of sensor data. We exhibit that our methodology outperforms by marking its accuracy as 98.76% and F1 score as 0.98.
Heliox improves minute-ventilation variability during incremental maximal exercise in COPD patients
Authors: S. Gomes Natalia , A. da Silva Weder , Pena Rafael , Chiappa Gaspar 
Published: April 2023

Fundamento: A limitação do fluxo aéreo expiratório durante o exercício está presente em uma certa fração de pacientes com doença pulmonar obstrutiva crônica (DPOC) e está associada ao desempenho prejudicado do exercício. Objetivos: O objetivo deste estudo foi investigar se o Heliox normóxico (79% He-21%O 2 ) pode melhorar a variabilidade da ventilação minuto ( v V´E) em pacientes com DPOC. Métodos: Em um estudo cruzado duplo-cego, 13 homens não hipoxêmicos (FEV 1 = 36,1 + 9,32 previsto) realizaram testes cardiopulmonares incrementais até o limite de tolerância (T lim ) enquanto recebiam Heliox ou ar ambiente (AR). A análise da variabilidade ventilatória foi realizada com Poincaréanálises por SD 1 (desvio padrão 1) e SD 2 (desvio padrão 2), para ventilação minuto, volume corrente e frequência respiratória. As respostas da ventilação durante o exercício, o consumo de oxigênio e a tolerância ao exercício foram analisados. A resposta do débito cardíaco (QT) foi monitorada por cardiografia de impedância. Resultados: A ventilação com Heliox resultou em uma diminuição no consumo de oxigênio [V'O 2 , 1161,71 ± 351,11 vs. 1238,05 ± 330,93 mL/min, P <0,05] e na produção de dióxido de carbono [V'CO 2, 1217,41 ± 300,90 vs. 1288,02 ± 321,66 mL/min, P <0,05] em comparação com o ar ambiente, devido a um aumento na ventilação (35,37 ± 9,55 vs, 31,05 ± 7,75 L, P <0,05) e na eficiência ventilatória após a inalação de Heliox ( 12,63 ± 2,91 vs 9,31 ± 4,15%, P <0,05). As respostas da variabilidade da ventilação aumentaram significativamente com Heliox em comparação com o ar ambiente. Conclusões: Normóxico Heliox aumenta a variabilidade da ventilação minuto durante o exercício de alta intensidade em pacientes com DPOC moderada a grave.
Metode Sam’iyah Syafawiyah terhadap Peningkatan Penguasaan Kosakata Bahasa Arab Siswa Kelas VII Madrasah Tsanawiyah Negeri 2 Kota Malang
Authors: Rahmahwati Silmi , Ahsanuddin Mohammad 
Published: April 2023

Abstract: Mufradat are language elements that must be mastered by students. When learning is hindered, the understanding and mastery of mufradat will be affected. The purpose of this research is to describe the application and effect of the sam'iyah syafawiyah method on improving the Arabic vocabulary mastery of class VII students at Madrasah Tsanawiyah Negeri 2 Malang. The method used by the researcher in this research is a quasi-experiment one group pretest-posttest design by taking a sample of class VII-I. The result of this research is the syntax in the learning process using the sam'iyah syafawiyah method with a focus on intensively drilling mufradat both oral and written. The syntax includes listening (ختوة الإستعبية), repetitive or repetition (ختوة التّكراريّة), explanation (ختوة التّحقيقيّة), using sentence patterns (ختوة القصاعيّة), generalization/conclusion (ختوة الإستنباطيّة), reading (ختوة الإستقرائيّة), and writing (ختوة الكتابيّة). In addition, data analysis through paired sample t test results in a calculated t value of 7.219 greater than the table t value of 1.708. The significance value obtained is 0.000 smaller than 0.05. The students' average posttest score is higher than the average pretest score, proving the positive effect of sam'iyah syafawiyah method on the mufradat mastery.
Keywords: mufradat; Arabic language; learning method; sam’iyah syafawiyah method
Abstrak: Mufradat merupakan tiga dari unsur bahasa yang harus dikuasai oleh peserta didik. Apabila pembel­ajaran terhambat, pemahaman dan penguasaan mufradat akan terpengaruh. Tujuan penelitian ini adalah untuk mendeskripsikan penerapan dan pengaruh metode sam’iyah syafawiyah terhadap peningkatan penguasaan kosakata bahasa Arab siswa kelas VII di Madrasah Tsanawiyah Negeri 2 Kota Malang. Metode yang digunakan oleh peneliti dalam penelitian ini adalah eksperimen semu one group pretest-posttest design dengan mengambil sampel kelas VII-I. Hasil penelitian ini adalah sintaksis dalam proses pembelajaran menggunakan metode sam’iyah syafawiyah dengan fokus pengedrillan mufradat secara intensif baik lisan maupun tulis. Sintaksis tersebut meliputi men­dengarkan (خطوة الإستماعية), repetitif atau pengulangan (خطوة التّكراريّة), eksplanasi (خطوة التّحقيقيّة), menggunakan pola kalimat (خطوة القواعديّة), generalisasi/kesimpulan (خطوة الإستنباطيّة), membaca (خطوة الإستقرائيّة), serta menulis (خطوة الكتابيّة). Selain itu, hasil t hitung 7,219 melalui uji paired sample t test lebih besar dari t tabel yakni 1,708. Nilai signifikansi yang diperoleh adalah 0,000 lebih kecil dari 0,05. Rata-rata nilai posttest peserta didik lebih tinggi dari rata-rata hasil nilai pretest. Membuktikan bahwa adanya pengaruh peningkatan penguasaan mufradat setelah metode sam’iyah syafawiyah diterapkan.
Kata kunci: mufradat; bahasa Arab; metode pembelajaran; metode sam’iyah syafawiyah
Peningkatan Keterampilan Menulis Huruf Hijaiyyah melalui Media Kartu Bergambar pada Siswa TK El Mu’jizah Malang
Authors: Amelia Alfianti , Nasih Ahmad Munjin 
Published: April 2023

Abstract: The Arabic teaching style for young children differs greatly from the teaching styled for pupils in elementary school and higher education level. Fundamentally, children only need to know a foreign language without learning it, earnestly. At Mu'jizah Kindergarten Malang, although Arabic program is one of its top program, some children in group B still did not know nor understand hijaiyah letters, hindering the practice of Arabic and limiting children's learning outcomes. The purpose of this study is to investigate the effects of flashcard media on kindergarten students’ hijaiyah writing skills improvement. This study used classroom action research method with two cycles. The obtained results suggested that the hijaiyah writing learning with flashcards media has been carried out, properly as shown from the increased teacher and student activity. Besides, we obtained significant results after the use of flashcard media in each learning cycle, with 0 learning result in pre-cycle, followed by 38.46 and 76.92 percent score in the first and second cycle, respectively.
Keywords: flashcards; writing; hijaiyyah letters
Abstrak: Cara mengajar bahasa Arab untuk anak usia dini sangat berbeda caranya dengan mengajar bahasa Arab pada anak di tingkat SD, SMP, atau SMA. Pada dasarnya, anak-anak hanya perlu tahu bahasa asing tanpa harus mempelajari semuanya. Objek penelitian ini adalah hasil belajar menulis huruf hijaiyyah kelompok B di TK El Mu’jizah Malang. Program unggulan TK El Mu’jizah adalah bahasa Arab namun terdapat beberapa anak kelompok B yang sama sekali belum mengenal dan paham huruf hijaiyyah, sehingga menghambat praktik bahasa Arab dan menurunnya hasil belajar anak. Maksud dan penelitian ini bertujuan untuk mendeskripsikan proses-proses menulis huruf hijaiyyah bersam­bung menggunakan media kartu bergambar dan menjelaskan peningkatan hasil praktik menulis huruf hijaiyyah kelompok B di TK El Mu’jizah Malang dengan menggunakan kartu ber­gambar. Penelitian ini merupakan penelitian tindakan kelas dalam dua siklus. Hasil yang diperoleh dalam penelitian ini adalah penggunaan media kartu bergambar dalam pembelajaran menulis huruf hijaiy­yah bersambung terlaksana dengan baik, buktinya adalah meningkatnya aktivitas guru dan siswa. Hasil setelah dilakukannya penggunaan media kartu bergambar dalam pembelajaran pada tiap siklusnya memiliki hasil yang sangat signifikan, yaitu pada prasiklus dengan hasil BSB 0 persen, Siklus I dengan hasil BSB 38,46 persen dan Siklus II dengan hasil BSB 76,92 persen.
Kata kunci: kartu bergambar; menulis; huruf hijaiyyah