bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transdiagnostic Skills Training Group of Dialectical Behavior Therapy: a Long-Term Naturalistic Study
Authors: DURPOIX Amaury , Lachaux Enzo , WEINER Luisa , WEIBEL Sébastien 
Published: May 2023

Abstract
Introduction.
Dialectical Behavior Therapy (DBT) has assembled a large body of evidence for the treatment of emotional dysregulation in borderline personality disorder (BPD), but also in other disorders characterized by emotional dysregulation (e.g., bipolar disorder (BD) and ADHD). Standalone skills learning groups address the problem of limited resources in several clinical settings. Furthermore, transdiagnostic skills groups facilitate recruitment and decrease scattering of resources in psychiatric settings. However, few studies have focused on the pertinence of transdiagnostic standalone skills groups in naturalistic settings as well as their long-term outcomes. The goal of this study is to assess the patients’ evolution one year after their participation in DBT transdiagnostic skills group.
Method.
Transdiagnostic DBT skills training groups were provided for BPD, BD and ADHD patients in a University Psychiatric Department (Strasbourg, France), between 2019 and 2020. It consisted of 16 group sessions of 2,5 hours and 3 individual sessions. At 1-year follow-up, ad-hoc questionnaires were proposed to all participants to assess their evolution.
Result.
22 of the 31 participants were interviewed at the one-year post-group session (64% BPD, 41% ADHD and 27% BD). 73% participants estimated that group impact was important or very important, 64% stated using the skills learned often or very often, mainly emotional regulation skills. An improvement in emotional instability, substance use, impulsivity and suicidal thoughts was reported by respectively 100%, 91%, 86% and 85% of participants. Quality of life improved according to 90% participants. All patients reported an improvement in suicidality during the post-group year, especially in suicide attempts. Psychotropic medication decreased in 59% of participants.
Discussion.
Our one-year naturalistic study suggests that transdiagnostic DBT skills training groups are promising in BPD, BD and ADHD patients with emotional dysregulation. The observational design and the lack of control group are the main limitation. Randomized controlled studies are warranted to confirm the long-term efficacy of transdiagnostic skills learning groups in naturalistic settings.
Breast cancer intrinsic YTHDF1 forms “cold” tumor and inhibits CD8+ T cells infiltration and function
Authors: Jing Lanyu , Zhou Kaiwen , Wang Zilin , Lin Ying 
Published: May 2023

Abstract
Backgrounds
While YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) was recognized as a crucial contributor in the development and immune-related regulation of various types of tumors, its function in the immune response of breast cancer has largely remained uninvestigated.
Methods
Through analysis of public databases, we found YTHDF1 as a highly expressed gene in breast cancers and confirmed this finding in breast cancer cells and clinical specimens from our center. Subsequently, we examined the link between YTHDF1 expression and immune cells and molecules by utilizing immune-related public databases. We further validated our findings through cellular and animal experiments, as well as RNA sequencing.
Results
We observed YTHDF1 highly expressed in tumor tissues of breast cancer, which negatively correlated with patient survival. The downregulation of YTHDF1 promoted the expression of pro-inflammatory markers and improved the anti-cancer ability of immune cells in breast cancer. RNA sequencing analysis revealed that YTHDF1 knockdown resulted in enrichment of differential genes in signal transduction pathways. Additionally, in vitro experiments showed that immune cells had higher cytotoxicity against breast cancer cells with decreased YTHDF1 expression. Moreover, in vivo studies indicated that YTHDF1 promoted breast cancer growth while inhibiting CD8+ T cell infiltration and function.
Conclusion
We demonstrated that YTHDF1 plays a crucial role in establishing a "cold" tumor microenvironment in breast cancer by inhibiting the release of pro-inflammatory cytokines from cancer cells. As a result, the infiltration and functional differentiation of anti-tumor CD8+ T cells are hindered, ultimately resulting in the immune evasion of breast cancer.
bFGF could modulate the anti-cancer effect of Cyclopamine and induce apoptosis in HT-29 colorectal cancer cells
Authors: Jodat Hosein , Asadi Zari Tahan Nejad , Dayer Dian , Amirrajab Nasrin 
Published: May 2023

Abstract
Colorectal cancer is the third most common cancer. The activity of the Sonic hedgehog pathway is increased in patients with colorectal cancer. bFGF and Cyclopamine could act as Shh pathway inhibitors. But, by considering the dual role of bFGF on the growth of cancer cells, this study aimed to evaluate the simultaneous effect of bFGF and Cyclopamine, on apoptosis in the HT-29 cell line. Cell viability was performed using MTT assay. The apoptosis rate was measured using Annexin V-FITC/PI flow cytometry. Clonogenic assay was performed. The gene expression was investigated using Real-Time PCR method. The bFGF decreased the expression of apoptotic genes. But, the Cyclopamine increased the expression of apoptotic genes and decreased the colony formation ability. Simultaneous treatment with bFGF and Cyclopamine was associated with decreased expression of anti-apoptotic genes and decreased colony formation ability. Despite the anti-apoptotic effect of bFGF on cancer cells, it increased the anti-cancer effect of Cyclopamine, which can be due to the existence of a less-known signaling pathway between bFGF and Shh to inhibit growth, so it is important to investigate its exact mechanisms.
The Surgical Decision-Making of Medical Staff with Thyroid Nodules: A Qualitative Study
Authors: Xu Qian , Sun Kaili , Guo Xiaoli , Chen Ting , Hu Jianli , Shi Yan 
Published: May 2023

Abstract
Objective
Few studies have explored the surgical decision-making of medical staff diagnosed with thyroid nodules. The objective of the current study was to gain insight into the decision-making of this special group of patients.
Methods
Interviews with 12 medical staff with thyroid nodules were conducted, audio-recorded, transcribed verbatim, and further analyzed.
Results
Most participants preferred to make the decisions by themselves or follow their doctors’ advice, while their family members did not participate in the decision-making. Participants’ surgical decision-making was hindered by diagnosis uncertainty, wardmate examples, and fears of surgeries and complications, but facilitated by the prognosis of Thyroid cancer, support from others, and sufficient evidence-based treatment knowledge. Some respondents regretted their surgeries for insufficient preoperative consideration and serious postoperative complications. In addition, they perceived that their family members regretted more than themselves due to their guilt of noninvolvement in the surgical decision-making.
Conclusions
Medical staff with thyroid nodules may make surgical decisions with trust in their doctors. However, some decisions were made without sufficient knowledge and preparation for possible complications or the involvement of family members. When complications occur unexpectedly, both the patients and their family members deeply regret their decisions. Healthcare providers should give sufficient treatment knowledge and psychological support, consider patient preferences, use shared-decision-maing(SDM), and involve family members in the surgical decision-making. In the future, artificial intelligence could be considered to enhance surgical decision making and overcome the weaknesses of traditional decision making.
Patient or Public Contribution
Public contributors were involved in the development of interview guidelines, study design, and study materials. Interview transcripts were reviewed by participants, who assisted in data analysis.
Structural and Frequency dependent Electrical Behaviour of Nanocomposite of La doped BiFeO 3 :SrAlO 3
Authors: Sharma Bhumika , Mukherjee Rupam , Rana Pawan S. 
Published: May 2023

Abstract
La doped BiFeO3:SrAlO3 samples were synthesized by sol-gel method. Composite was made to synthesise nano powder in order to improve electrical, optical and thermal properties. Goldschmidt tolerance factor for SrAlO3 is 0.9 which confirms this assembly to be a promising Perovskite. Investigations were carried out on samples where formation of false perovskite is verified by X-ray diffraction technique. The dielectric loss (tan δ) and conductivity (σ) were measured at room temperature as a function of the frequency (100 Hz – 25kHz). Structural and Electrical properties of this nanocomposite make them potential candidate in the field of thermoelectric energy devices.
Efficiency of essential oils emulsions against Whitefly Bemisia tabaci (GENN.) infesting potato plants under field conditions In Egypt
Authors: Wahba Trandil fayez , Wahba Mona N. , Abd-Elatef Enase Adel 
Published: May 2023

Abstract
The whitefly, Bemisia tabaci, nymphs, and adults sucking sap Excessive use of pesticides caused pollution of the environment and the death of beneficial insects, it is one of the most damaging pests of Potato, Solanum tuberosum, so it was necessary to search for more safe alternatives. An experiment was carried out during seasons 2021 and 2022 under field conditions in Egypt. The objective of this study aimed to use peppermint and eucalyptus essential oils and prepare coarse emulsions and nanoemulsions (CE and NE) of both peppermint and eucalyptus essential oils. The results reported that the numbers of nymphs per plant before treatment during season 2022 were greater than those in season 2021, which may be due to increasing temperature and decreasing precipitation, specific humidity, and wind speed. On the other hand, essential oil's nanoemulsion (NE) was more effective in controlling B. tabaci. Generally, the toxicity decreased with time after spraying. The second spray was more effective than the first spray. P (CE, NE) revealed the most effectiveness, followed by E (CE, NE) during both seasons. During season 2021, the NEs were slightly more effective than the CEs. During season 2022, recorded no significant difference between CEs and NEs. Also, the toxicity of the tested emulsions was highly effective during season 2021 compared with 2022 due to decreasing temperatures in December 2021 compared to December 2022. The study of the growth component deduced that the parameters of potato plants after being treated with tested emulsions showed that both peppermint coarse emulsion PCE and eucalyptus coarse emulsion ECE achieved slightly decreased portion levels. ECE increased total plant carbohydrates. However, our treatments did not affect the phenolic compounds of potato leaf plants, although ENE caused an increase in phenolic compounds. All treatments decreased the nitrogen plants' contents. Furthermore, PCE, PNE, and ENE increase the potassium content. All treatments increase the activity of peroxidase (POX) compared with untreated plants. The formulation obtained here might be an interesting alternative for integrated pest management of B. tabaci nymphs.
Training nurses to facilitate and implement CURA in palliative care institutions: development and evaluation of a blended learning program
Authors: Schaik Malene van , Kröger Charlotte , Zuidema Catharina Elisabeth , Stolper Margreet , Widdershoven Guy , Pasman H. Roeline , Metselaar Suzanne 
Published: May 2023

Abstract
Background Healthcare professionals in palliative care are found to be confronted with moral challenges on a frequent basis. CURA is a low-threshold instrument for dialogical ethical reflection that was developed to deal with these challenges. A previous study identified the need of healthcare professionals to be trained to introduce CURA in their organization, initiate and facilitate reflections with CURA, and contribute to the implementation of CURA. The aim of this study was to develop and evaluate a training for professionals to become ‘CURA-ambassadors’.Methods The training was developed in a participatory way in two cycles. We trained 72 healthcare professionals. The training was evaluated by means of a questionnaire and six semi-structured interviews.Results The study resulted in a blended learning training combining training sessions with an e-module and with practicing with organizing and facilitating CURA in daily healthcare practice. The main objectives of the training are to enable CURA-ambassadors to introduce CURA within their organization, initiate and facilitate ethical reflections using CURA, and contribute to the implementation of CURA. Participants were generally positive about the training program and the trainers. Technical difficulties related to the e-module were mentioned as main point of improvement.Discussion The training program can generate ownership, responsibility, and competency among CURA-ambassadors, which are essential foundations for implementing complex interventions in healthcare practice. The training program received positive evaluations shortly after completing the program. This study adds to our understanding of what is needed for healthcare professionals to use CURA, in order to support them in dealing with moral challenges and to foster their moral resilience. Further research is needed to assess whether participants experience the training as sufficient and effective when using and implementing CURA structurally in their organizations over a longer period of time.
Agrochemical inputs and management have a greater impact on common bean rhizobia diversity than drought
Authors: Canto Arantza del , Grillo Michael A. , Heath Katy D. , de Jauregui Álvaro Sanz Saez , Heras Jonathan , Lacuesta Maite 
Published: May 2023

Abstract
Drought is one of the biggest problems for crop production and also affects the survival and persistence of soil rhizobia. The reduced presence of rhizobia limits the establishment of symbiosis and endangers the productivity of legumes, the main source of plant protein worldwide. Thus, the preservation of soil microbial diversity is essential because it can ameliorate crop response to stress by increasing the likelihood of the presence of stress-tolerant rhizobia and the chances of establishing effective symbiotic relationships. Aim Since the biodiversity can be affected by several factors including abiotic stress or cultural practices, the objective of this research was to evaluate the effect of water availability, plant genotypes and agricultural management on the presence, nodulation capacity and genotypic diversity of rhizobia. Method For that, a field experiment was conducted, with twelve common bean genotypes under irrigation and rain-fed conditions, both in conventional and organic management. Estimation of the number of viable rhizobia present in soils was performed before the crop establishment, whereas the nodule number and the strain diversity of nodule bacteria were determined at postharvest. Results Drought reduced the number of nodules and of isolated bacteria and their genetic diversity, although in a lesser extent than the agrochemical inputs related to conventional management. Conclusions Thus, the maintenance of diversity will be a key factor in the future, as problems caused by drought will be exacerbated by climate change.
Traumatic brain injury in mice generates early-stage Alzheimer’s disease related protein pathology that correlates with neurobehavioral deficits
Authors: Panayi Nicholas , Schulz Philip , He Ping , Hanna Brandon , Lifshitz Jonathan , Rowe Rachel , Sierks Michael R 
Published: May 2023

Abstract
Traumatic brain injury (TBI) increases the long-term risk of neurodegenerative diseases, including Alzheimer’s disease (AD). Here, we demonstrate that protein variant pathology generated in brain tissue of an experimental TBI mouse model is similar to protein variant pathology observed in human ADbrains, and that subacute accumulation of two AD associated variants of amyloid beta (Aβ) and tau in the TBI mouse model correlated with behavioral deficits. Male C57BL/6 mice were subjected to midline fluid percussion injury or to sham injury, after which sensorimotor function (rotarod, neurological severity score), cognitive deficit (novel object recognition), and affective deficits (elevated plus maze, forced swim task) were assessed at different days post-injury (DPI). Protein pathology at 7, 14, and 28 DPI was measured in multiple brain regions using an immunostain panel of reagents selectively targeting different neurodegenerative disease-related variants of Aβ, tau, TDP-43, and alpha-synuclein. Overall, TBI resulted in sensorimotor deficits and accumulation of AD-related protein variant pathology near the impact site, both of which returned to sham levels by 14 DPI. Individual mice, however, showed persistent behavioral deficits and/or accumulation of selected toxic protein variants at 28 DPI. Behavioral outcomes of each mouse were correlated with levels of seven different protein variants in ten brain regions at specific DPI. Out of 21 significant correlations between protein variant levels and behavioral deficits, 18 were with variants of Aβ or tau. Correlations at 28 DPI were all between a single Aβ or tau variant, both of which are strongly associated with human AD cases. These data provide a direct mechanistic link between protein pathology resulting from TBI and the hallmarks of AD.
Assessment of Polonium-210 in Commonly Consumed Vegetables and Fruits in Kuwait
Authors: Alboloushi Aishah , Alboloushi Omar 
Published: May 2023

Abstract
210Po is the dominant contributor to the effective dose in humans, where a quarter of the total annual committed effective dose from ingestion of the food is coming from 210Po according to UNSCEAR data. Such a study is crucial nowadays because the consumption rate of vegetables and fruits has remarkably increased. Also, 210Po/210Pb activity in Kuwait air has been reported as a ratio of about 1, and this may result in the enhancement of 210Po concentration in locally cultivated leafy vegetables due to the deposition of air-suspended solid particles since Kuwait is known to be a dusty country; however, the radiological data available on 210Po concentrations and its associated ingestion dose for the Kuwaiti local diet is still limited. 210Po wet activity concentration (Bq/kg), an annual intake (Bq/y), and committed effective dose due to the ingestion of most consumed vegetables and fruits (µSv/y) were calculated and evaluated (annual dose was assessed to be 13.6 ± 2.5 µSv/y. Moreover, washed and non-washed leafy vegetables have been analyzed for 210Po to investigate the atmospheric fallout contribution. Conclusively, 210Po baseline data has been established for fruits and vegetables in Kuwait, and they are considered lower than some reported international data confirming their radiological safety. Further determination of 210Po in different consumed meat and seafood species will be carried out.
Corticospinal Adaptation to Short-term Horizontal Balance Perturbation Training
Authors: Hu Nijia , Piirainen Jarmo M , Walker Simon , Avela Janne 
Published: May 2023

Abstract
Sensorimotor training and strength training can improve balance control. Currently, little is known how repeated balance perturbation training affects balance performance and its neural mechanisms. This study investigated corticospinal adaptation assessed by transcranial magnetic stimulation (TMS) and H-reflex measurement during balance perturbation induced by perturbation training. Fourteen subjects completed three perturbation sessions (PS1, PS2, and PS3). The perturbation system operated at 0.25 m/s, accelerating at 2.5 m/s2 over 0.3 m displacement in anterior or posterior direction. Subjects were trained by 200 perturbations in PS2. In PS1 and PS3, TMS and electrical stimulation elicited motor evoked potentials (MEP) and H-reflexes in the right leg soleus muscle, at standing rest and two-time points (40 ms and 140 ms) after perturbation. Body sway was assessed using the displacement and velocity of the center of pressure (COP), which showed a decrease in PS3. No significant changes were observed in MEP or H-reflex between sessions. Nevertheless, Δ MEP at 40 ms demonstrated a positive correlation with Δ COP, while Δ H-reflex at 40 ms demonstrated a negative correlation with Δ COP. Balance perturbation training indicated less body sway and a potential increase of spinal-level involvement was observed when movement automaticity enhances after perturbation training.
Implementation of Rapid COVID-19 Testing in Criminal Justice Residential Re-entry Sites
Authors: Ngassa Yvane , Finn Julie , Brinkley-Rubinstein Lauren , Wurcel Alysse 
Published: May 2023

Abstract
The goal of our project was to study the implementation of rapid BINAX COVID-19 testing at criminal justice re-entry sites, focusing on several framework-guided implementation outcomes. We implemented rapid COVID-19 testing at nine re-entry sites in four states (Massachusetts, New Hampshire, Rhode Island, and New York) and collected test results to measure the 1) adoptability and 2) implementability of COVID-19 testing at re-entry sites. We also collected data on the acceptability, appropriateness, and feasibility of the implementation of COVID-19 testing using an anonymous employee Qualtrics survey.Testing was available to symptomatic and exposed residents and employees. COVID-19 testing results were collected from October 2021 to March 2022. Guided by the Expert Recommendations in Implementing Change (ERIC) framework, we chose nine implementation strategies to address barriers during the implementation process. Eight testing sites used a total of 302 BINAX COVID-19 tests and reported a total of 26 positive cases. Across all testing sites, 47% of employees participated in the survey. Most survey participants agreed that the implementation of rapid COVID-19 testing at re-entry sites was acceptable, feasible and appropriate. COVID-19 testing at nine re-entry sites was possible through collaboration with CRJ leadership. Several cases of COVID-19 were identified, especially during the peak months of the pandemic. Funding and attention toward COVID-19 testing at re-entry sites should be provided to help prevent the spread of COVID-19 in re-entry sites and their surrounding communities.
In-Season Growth Forecasting in Cotton Using Unmanned Aerial System- based Canopy Attributes and LSTM Models
Authors: Dhal Sambandh Bhusan , Bhandari Mahendra , Gadepally Krishna Chaitanya , Acharya Bharat Sharma , Pal Pankaj , Landivar Jose , Zhao Lei , Rout Tapas , Landivar Juan , Nowka Kevin , Kalafatis Stavros 
Published: May 2023

Abstract
Cotton (Gossypium spp.) is one of the important cash crops in the United States. Monitoring in-season growth metrics, from early season growth to harvest, is crucial for predictive and prescriptive cotton farming. In recent years, forecasting models have garnered considerable attention to predict canopy indices. This allows selection of management options during crop growth to boost cotton yield and profitability. Here, we used unmanned aerial system-derived canopy features, including canopy cover, canopy height, and excess green index, collected from 3500 plots at Driscoll in Corpus Christi, Texas during the years 2019, 2020, and 2021 for in-season growth forecasting. Training datasets in our model were produced by K-Means clustering and Dynamic Time Warping (DTW) techniques were used to compare various Long Short-Term Memory (LSTM) models in predicting the three canopy features. Accuracy was determined using Root Mean Square Error (RMSE). Results indicated higher predictive capacity of Convolutional Neural Networks (CNN) LSTM for canopy cover, and multi-layer stacked LSTMs for canopy height and excess green index respectively. Overall, results show tremendous potential for in-season growth forecasting and management of agricultural inputs like pesticides and fertilizers for improving crop health and productivity.