bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of a «short-term» preoperative endocrine therapy for adjuvant therapy guidance in early HR+ HER2-negative breast cancer
Authors: Druzhinina D. I. , Frolova M. I. , Stenina M. B. , Julikov Ya. A. , Evdokimova E. V. , Petrovsky A. V. , Artamonova E. V. 
Published: January 2025

In the absence of widespread access to genomic tests there is an urgent need for additional methods that influence the choice of adjuvant therapy in patients with early luminal Her2-negative subtype of breast cancer (BC). The IMPACT and POETIC trials have shown that Ki67 level decrease up to ≤10% after a “short-term” (2–4 weeks) preoperative endocrine therapy (ET) is a favorable prognostic factor. This test allows some patients to avoid adjuvant chemotherapy associated with immediate and delayed adverse events.Aims of the study. To evaluate the impact of “short-term” preoperative endocrine therapy for guidance of further treatment for patients with primary operable luminal Her2-negative breast cancer stages T1–3 N0–1 M0.Results. The study included 123 patients, 76 (60.8%) received tamoxifen and 47 (37.6%) – aromatase inhibitors (AI). Most patients – 69 (55.2%) were >50 years old, premenopausal – 58 (46.4%), menopausal – 67 (53.6%). The average age was 52 years (30–82). With the initial Ki67 level>10% (N= 107), Ki67 decreased in 24 (22.4%) up to ≤10% after “short-term” ET, and remained >10% in 83 (77.6%). According to the PREDICT calculator, the benefit of adjuvant chemotherapy (AChT) was assessed as high in 35 (28.5%) patients, and 10 of them (27.8%) were able to avoid Ch T. In 86 patients with a relatively low estimated AChT benefit (<5% at 10 years) there was no response to “short-term” ET, which led to the AChT prescription in 13 cases (15.1%).Conclusions. “Short-term” course of preoperative endocrine therapy is a simple, accessible and reproducible method for personalizing of adjuvant therapy in patients with luminal HER2-negative breast cancer.
Long-term side effects of neurotoxicity of antitumor therapy in children who survived lymphoid tumors
Authors: Kuznetsova E. I. 
Published: January 2025

Relevance. Improving the diagnosis and treatment of children with lymphoid tumors (LT) contributes to an increase in the number of cured patients. Antitumor therapy has a side effect on the nervous system, and can lead to neurotoxic consequences. Due to the increased life expectancy of children cured of LT, the assessment of the long-term neurotoxic effects of antitumor therapy is relevant.Objective: based on the literature data, to study the long-term neurotoxic side effects of antitumor therapy in children cured of LT.Material and methods. When writing a literature review, data were analyzed in specialized medical databases Pubmed, Scopus, Web of Science on research in children cured of lymphoid tumors from 1993 to 2023.Results. In cured children from lymphoid tumors, the long-term neurotoxic effects of therapy containing methotrexate in high doses are manifested by neurocognitive decline and structural changes in the brain. Late peripheral neuropathy caused by vincristine affects the quality of life of patients in physical and social aspects. However, the prognostic parameters of long-term neurotoxic effects in children cured of LT have not been determined. The issues of monitoring patients in the long term have not been sufficiently studied. This will contribute to the rehabilitation and long-term follow-up of patients with oncohematological diseases, and improve their quality of life.
Conventional and complementary alternative medicine therapies for renal anemia: a literature review
Authors: Lu Ching-Ming , Hsu Yuan-Hsuan , Lin I-Hsin , Kuo Ko-Lin , Liao Jian-Fu , Huang Hui-Fen , Lu Ping-Hsun 
Published: January 2025

Renal anemia stems mainly from chronic inflammation with elevated hepcidin levels, iron deficiency, and reduced red blood cell lifespan. Inadequate erythropoietin (EPO) production, worsened kidney function, leads to symptoms such as low energy, fatigue, and impaired physical function, significantly affecting patients’ quality of life. We conducted a comprehensive search across electronic databases including PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure, Airiti library, and Wanfang, to compile recent clinical trials and pilot studies on conventional and complementary alternative medicine approaches for renal anemia. This discussion focuses on the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD) axis theory, from lab research to clinical applications. It explores non-extracorporeal treatments for renal anemia, including pharmaceutical interventions, dietary strategies, and complementary and alternative medicine (CAM). The article details the effects of Roxadustat, Ferumoxytol, and Epodion.Clinical studies show that modulating the gut microbiome can reduce inflammation and improve renal anemia. Clinical trials suggest that CAM therapy can improve renal anemia through mechanisms such as enhanced iron metabolism, anti-inflammatory effects, reduced hepcidin levels, and increased EPO and HIF expressions. By synthesizing this information, the review aims to furnish valuable insights and treatment recommendations aimed at ameliorating renal anemia in individuals grappling with chronic kidney disease.
No association of ABO blood groups and Rh factor with primary liver cancer in cirrhotic patients: a single-center cross-sectional study
Authors: Dong Liyan , Yin Yuhang , Lu Huiyuan , Sun Di , Wang Dongyang , Zou Deli , Qi Xingshun 
Published: January 2025

BackgroundPrimary liver cancer (PLC) is one of the most common cancers worldwide. ABO blood groups and rhesus (Rh) factor are inherited characteristics. Their association with the presence of PLC remains unclear in cirrhotic patients. Hence, the purpose of this cross-sectional study was to evaluate whether blood groups were risk factors for the presence of PLC in cirrhosis.MethodsPatients with liver cirrhosis who were consecutively admitted to the Department of Gastroenterology of the General Hospital of Northern Theater Command from 1 January 2010 to 30 June 2014 were retrospectively screened. Logistic regression analyses were performed to explore the association of ABO blood groups and Rh factor with PLC in cirrhotic patients. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were calculated after adjusting for gender, age, family history of liver cirrhosis, HBV-DNA positivity, and etiology of cirrhosis. Subgroup analyses were performed according to the etiology of liver cirrhosis.ResultsOverall, 1,158 cirrhotic patients without PLC and 240 cirrhotic patients with PLC were included in the study. After adjusting for confounding factors, non-O (aOR = 0.763; 95%CI = 0.449–1.298, p = 0.319), A (aOR = 0.643; 95%CI = 0.332–1.246, p = 0.191), B (aOR = 0.835; 95%CI = 0.453–1.540, p = 0.564), AB (aOR = 0.888; 95%CI = 0.363–2.170, p = 0.795), and Rh (+) (aOR = 0.239; 95%CI = 0.036–1.571, p = 0.136) blood groups were not independently associated with PLC in cirrhotic patients. In the subgroup analysis of HBV-related cirrhotic patients, the proportion of A blood group was significantly lower in cirrhotic patients with PLC than in those without PLC (24.17% vs. 33.99%, p &lt; 0.001); however, in HCV- and alcohol-related cirrhotic patients, the proportions of ABO blood groups and Rh factor were not significantly different between the two groups.ConclusionABO blood groups and Rh factor may not be associated with the presence of PLC in cirrhotic patients.
A bibliometric analysis of exosomes in aging from 2007 to 2023
Authors: Niu Zenghui , Cui Meiyu , Fu Yingkun , Zhou Lingfeng , Wang Jiali , Lei Yan , Fan Xinrong , Wang Qiang , Yang Jing 
Published: January 2025

BackgroundAging is the primary factor contributing to the development of aging-related diseases. As research on exosomes continues to advance, its relationship with aging and aging-related diseases has become a hot topic This article analyzes the research hotspots of exosomes in aging and aging-related diseases, aiming to fill the gap in bibliometric research in this field and help researchers better understand the current status and future trends of both fundamental and clinical research in this field.MethodsThe articles were retrieved and exported from WoSCC on December 18, 2023. The visual analysis of countries and regions, institutions, authors, references, and keywords in exosomes of aging was conducted using VOSviewer 1.6.18, CiteSpace 6.2.R7, and Bibliometrix.ResultsThe bibliometric analysis included 1628 articles. China and the United States emerged as the top two leading countries in this field. A total of 2,321 research institutions from 78 countries and regions were primarily led by China and the United States. Both Kapogiannis D and Goetzl E were active authors in this field. Thery C, Valadi H, and Raposo G were the important promoters in this field. Thery C proposed the method of differential centrifugation and density gradient centrifugation to extract exosomes. Valadi H discovered cells could send RNA-messages to each other by loading them into exosome-vesicles. The journal with the highest number of articles was International Journal of Molecular Sciences, while PLoS One was the most frequently cited journal. The keyword analysis revealed that future research on exosomes in aging will possibly focus on “inflammation, cellular senescence, angiogenesis, insulin resistance, and Alzheimer's disease.”ConclusionWe identified the research trends of exosomes in the field of aging through this bibliometric analysis. The present study provides valuable new perspectives on the history and current status of exosomes in the field of aging and aging-related diseases, and also offering guidance for future research directions.
The diagnosis and treatment of 56 cases of breast hamartoma: a single-center analysis and a review of the literature
Authors: Su Hao , Bai Caiyun , Fan Zhimin , Wu Di , Qu Fengjiang 
Published: January 2025

IntroductionTo analyze and summarize the clinical and pathological features of breast hamartoma to enhance clinicians’ awareness of this rare and benign lesion of the breast.MethodsWe retrospectively described the clinical data, imaging results, and pathological findings of 56 patients with breast hamartoma who underwent surgical treatment at the First Hospital of Jilin University between January 2005 and December 2020, and summarized the features. Additionally, a literature review was conducted using the PubMed database for clinical reports on breast hamartoma and analyzed them.ResultsThis study included 56 female patients. Preoperative ultrasound revealed round or elliptical heterogeneous echoes with clear boundaries: hypoechoic in 35 cases (63%), iso-echoic in 8 cases (14%), hyperechoic in 1 case (2%), mixed echo in 9 cases (16%), slightly strong echo in 1 case (2%), and uneven echo of fat in 2 cases (4%). Mammography was performed in 33 cases, revealing clear and dense shadows in 20 cases (61%) and dense shadows on the outer edges in 16 cases (48%). The excised masses were solid, with light yellow and gray cut surfaces. Pathological analysis identified ducts and fibrous tissue, with intra-tumoral fat content ranging from 10 to 90%.ConclusionBreast hamartoma is prevalent among perimenopausal women and is characterized by ultrasound and radiography; surgical intervention remains the primary treatment with a good prognosis.
Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study
Authors: Dai Suming , Wang Ping , Wang Sijia , Chen Hong , Cui Zhixin , Lu Wenhai , Zhou Ziyi , Zhang Nan , Wang Zhuo , Lin Tengfei , Song Yun , Liu Lishun , Huang Xiao , Chen Ping , Tang Genfu , Duan Yong , Zhang Hao , Wang Binyan , Yang Yan , Tian Zezhong 
Published: January 2025

BackgroundExisting epidemiological studies investigated the association between a single vitamin and hypertension. However, the potential relationship between the level of circulating multivitamins and blood pressure has not been explored. We aimed to investigate the association between multiple fat-soluble vitamin levels and blood pressure.MethodsA total of 2052 participants with essential hypertension were sampled nationwide. The plasma concentrations of fat-soluble vitamins (A, E, D, and K) were assessed using liquid chromatography coupled with the mass spectrometry method. Participants were categorized into different co-exposure patterns using the unsupervised K-means clustering method. The multiple linear regression model was used for subsequent analyses.ResultsParticipants were classified into two co-exposure patterns of fat-soluble vitamins. The levels of vitamins were relatively low in pattern 1, compared to pattern 2. Participants in pattern 2 had no significantly different blood pressure levels compared to pattern 1. However, the plasma 25-hydroxyvitamin D3 (VD3) levels were negatively associated with SBP (logarithmic 10 transformed) (β = −0.002, 95% CI: −0.004, 0); participants in the fourth α-tocopherol quartile had mean SBP levels that were 1.02% (95% CI: 0.43, 1.61%) greater than those in the lowest quartile (p for trend &lt;0.01). In addition, no significant relationships were found between plasma VA/VK concentrations and blood pressure.DiscussionAlthough no significant association between fat-soluble vitamin co-exposure patterns and blood pressure was found, further analyses could imply that plasma α-tocopherol levels may offset the potential protective effect of plasma VD3 on blood pressure among hypertensive adults. This provided a novel perspective for exploring the joint effects of fat-soluble vitamins on blood pressure. Further studies are warranted to better understand the implications.
Effects of ultra-processed foods on the liver: insights from gut microbiome and metabolomics studies in rats
Authors: Shi Liping , Li Zhuoyuan , Ma Xiaojun , Wang Junru , Wu Yueping , Zhu Yongbin , Wang Yanrong , Yang Yue , Luo Minxiu , Li Jiangping , Sun Xian , He Shulan 
Published: January 2025

PurposeHigh consumption of Ultra-processed foods (UPF) have been identified as a potential risk factor for Non-alcoholic fatty liver disease (NAFLD). Nevertheless, there is limited empirical evidence regarding the impact of UPF, which are typical combination of processed foods, on liver health through alterations in gut microbiota and metabolic processes. We aim to examine the potential impact of UPF on liver health and to explore the role of gut microbiota and metabolites.MethodsThis study used Sprague–Dawley rats to mimic modern UPF diets for 90 days. Some serum biochemical indices, inflammatory factors, oxidative stress markers, hematoxylin–eosin (HE) staining of the liver, 16S ribosomal RNA (rRNA) and Liquid chromatography-mass spectrometry (LC–MS) of rat feces were detected.ResultsThe UPF diet-induced simple steatosis of the liver in rats without affecting the levels of IL-6, GSH, MDA, and SOD. Additionally, it modified the gut microbiota, increasing potentially harmful bacteria, such as norank_f__Desulfovibrionaceae and Staphylococcus, while also elevating the relative abundance of potentially beneficial bacteria, including Dubosiella and Allobaculum. Furthermore, the consumption of UPF led to a metabolomic disorder characterized by disruptions in the sphingolipid signaling pathway, sulfur relay system, and arachidonic acid metabolism.ConclusionIn conclusion, the findings of this study indicate that the consumption of UPF influences the development of simple hepatic steatosis, potentially through alterations in gut microbiota and metabolomics.
Spatiotemporal models with confounding effects: application on under-five mortality across four sub-Saharan African countries
Authors: Fenta Haile Mekonnen , Chen Ding-Geng , Zewotir Temesgen T. , Rad Najmeh Nakhaei 
Published: January 2025

BackgroundDifferent strategies have been developed to minimize under-five mortality (U5M) in sub-Saharan African (sSA) countries; however, it is still a major health concern for children in the region. Spatiotemporal modeling is important for areal data collected over time. However, when the number of time points and spatial areas is large and the areas are disconnected, fitting the model becomes computationally complex because of the high number of required parameters to be estimated. Therefore, the main aim of this study is to adopt a spatiotemporal dynamic model that includes the confounding effects between time, space, and their interactions with fixed covariates, with a special emphasis on U5M across disconnected sSA countries.MethodWe used nationally publicly representative Demographic and Health Survey (DHS) data for the period from 2000 to 2020. Bayesian spatiotemporal hierarchical modeling with an integrated nested Laplace approximation (INLA) program was used to model the spatiotemporal distribution of U5M among children across 37 districts located in four disconnected sSA regions: Ethiopia, Nigeria, Zimbabwe, and Ghana.ResultsA total of 170,356 under-five children from 37 districts were considered, and 15,467 died before the age of five. The relative risk of U5M in the first DHS was 2.02, which sharply decreased to 0.5 in the recent phase. The proportion of improved access to water, sanitation, clean fuel use, urbanization, and access to health facilities in the district had a significant negative association with U5M. The higher the proportion of these covariates, the lower is the prevalence of childhood mortality.ConclusionThis study revealed evidence of strong spatial, temporal, and interaction effects that influence under-five mortality risk across districts. Improving the women’s literacy index, access to improved water, the use of clean fuel, and the wealth index are associated with an improvement in the risk of mortality among under-five children across the districts. Districts in Nigeria and Ethiopia have the highest risk of U5M; hence, districts in these countries require special attention.
Healthcare Access vs. Quality Healthcare: Rethinking Healthcare Risks
Authors: Kumah Augustine 
Published: January 2025

ObjectivesThis narrative literature review examines the global burden of mortalities due to poor quality care compared to mortalities resulting from lack of access to healthcare, focusing on the period from 2015 to 2024.MethodsData was extracted from electronic databases such as PubMed, Google Scholar, Scopus, Ebscohost, and WHO. Relevant statistics on mortality rates due to poor quality care and lack of access to healthcare from the identified data sources were extracted. Descriptive statistics were used to summarize the mortality rates, with trends analyzed over the 10 years.ResultsThe results indicate that while progress in healthcare access has reduced mortality, the lack of corresponding improvements in care quality has led to a rising number of preventable deaths. The findings reveal a consistent decline in mortality due to lack of access. In contrast, mortality due to poor quality care has increased from 5 million in 2015 to an estimated 6 million by 2024, underscoring the persistent challenges in healthcare delivery, including medical errors, misdiagnoses, and inadequate treatment.ConclusionAddressing the dual challenges of access and quality is essential for reducing global mortality rates and achieving better health outcomes.
Основные факторы и источники экономического роста
Authors: Урайымов Н.Ж. 
Published: January 2025

В данной статье рассматриваются тенденции и модели экономического роста, его понятия и измерения. Раскрыты основные источники и факторы экономического роста, а также методы и инструменты их государственного стимулирования.
This article discusses the trends and models of economic growth, its concepts and dimensions. The main sources and factors of economic growth, as well as the methods and tools of their state stimulation are disclosed.
Оценка конкурентоспособности ДЮСШ методом построения многоугольника конкурентоспособности
Authors: Бланько М.И. , Шарапова В.М. 
Published: January 2025

В статье дана оценка конъюнктуры рынка детско-юношеских школ по хоккею с мячом в Свердловской области и анализ деятельности конкурентов. В статье рассмотрены основные конкуренты детской юношеской школы по хоккею с мячом с применением концепции «4P» и многоугольника конкурентоспособности
The article provides an assessment of the market conditions for youth hockey schools in the Sverdlovsk region and an analysis of the activities of competitors. The article discusses the main competitors of the children's youth hockey school using the concept of "4P" and the competitiveness polygon
Методы оценки финансовых ресурсов банка
Authors: Ананченко Д.С. 
Published: January 2025

в статье рассмотрены понятие и структура ресурсов коммерческого банка; описаны существующие методики оценки ресурсов. Обоснована необходимость грамотного выбора методики оценки финансовых ресурсов коммерческого банка.
the article discusses the concept and structure of commercial Bank resources; describes the existing methods of resource assessment. The need for a competent choice of methods for evaluating the financial resources of a commercial Bank is justified.
Методика анализа использования основных средств промышленного предприятия
Authors: Кураев И.А. 
Published: January 2025

Данная статья посвящена использования основных средств, приведены основные показатели. В статье приведены теоретические аспекты и анализ использования основных средств АО «Завод им. Гаджиева»
This article is devoted to the use of fixed assets, the main indicators are given. The article presents the theoretical aspects and analysis of the use of fixed assets of JSC them. Gadzhieva
Разработка смягчающих мер для сдерживающих факторов девелоперских проектов
Authors: Волков А.Н. 
Published: January 2025

Девелоперские проекты могут быть доведены до успешного завершения различными способами. Но лучшие и наиболее популярные методы и рамки управления проектами постоянно меняются. Новые понятия появляются все время. За успешными проектами стоит целая цепочка методов, инструментов и приемов. Однако методы и рамки управления проектами предназначены не только для руководителей проектов. Вся команда проекта должна понимать их использование, назначение и основные термины. Это гарантирует, что весь процесс будет идти гладко независимо от выбора. Методология или рамки, которые работали для кого-то другого, могут быть не совсем подходящими для рассматриваемой девелоперской компании. Вот почему лучше всего проверить, как мы можем использовать методы и инструменты для собственных проектов. В статье описываются варианты разработки смягчительных мер для контроля сроков при осуществлении девелоперских проектов.
Development projects can be brought to successful completion in various ways. But the best and most popular project management methods and frameworks are constantly changing. New concepts appear all the time. Successful projects have a whole chain of methods, tools and techniques. However, the methods and framework of project management are not only for project managers. The entire project team must understand their use, purpose and basic terms. This ensures that the entire process runs smoothly, regardless of choice. The methodology or framework that worked for someone else may not be entirely appropriate for the development company in question. That’s why it’s best to check how we can use the methods and tools for our own projects. The article describes options for developing mitigation measures to control the timing of development projects.