bluuebunny/crossref_metadata_2025_split huggingface dataset:
All-polyethylene versus metal-backed tibial components in total knee arthroplasty: a meta-analysis of randomized controlled trials
Authors: Elmhiregh Aissam , Abuodeh Yousef , Alzobi Osama , Zikria Bashir , Alkhayarin Mohd , Morrey Bernard F. 
Published: May 2023

Abstract
Objectives
The design of tibial trays for total knee arthroplasty (TKA) has been a topic of research for several decades. Although all-polyethylene trays were developed to address issues such as osteolysis and to enhance the longevity of the prosthesis, as well as knee range of motion, metal-backed designs have remained the most commonly used type of prosthesis. This meta-analysis aimed to compare the clinical, radiological, and survival outcomes of both designs.

Methods
Five databases were searched from inception until October 1, 2020, for randomized controlled trials (RCTs) that compared the outcomes of all-polyethylene and metal-backed tibial components in TKA. The outcomes of interest included range of motion, knee society score, stairs climbing scores, radiostereographic analysis, survivorship and complication. This review was conducted in line with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Risk of bias was assessed using the Newcastle–Ottawa tool.

Results
A total of 14 RCTs with 1367 TKA were included with a mean age of – years and – years for all-polyethylene and metal-backed tibial components groups, respectively. All-polyethylene group demonstrated statistically significant differences in five-year survivorship (OR 0.27; 95% CI 0.10–0.75; p value 0.01) and stairs climbing score (OR − 2.07; 95% CI − 3.27–0.87; p value 0.0007) when compared to the metal-backed group. The metal-backed design was significantly more radiographically stable in anterior–posterior, varus–valgus, and internal–external rotations at the 2-year follow-up compared to all-polyethylene tibias (OR − 0.09; 95% CI − 0.16 to − 0.02; p value 0.02) as per the pooled radiostereographic analysis. However, ten-year survivorship (OR 0.92; 95% CI 0.53–1.60; p value 0.78), range of motion (OR − 0.57; 95% CI − 2.00–0.85, p value 0.43), knee society scores (OR 1.38; 95% CI − 0.47–3.23, p value 0.14), and complications (OR 0.83; 95% CI 0.5–1.39, p value 0.48) were comparable between both groups.

Conclusions
While this meta-analysis suggests that all-polyethylene tibial components in total knee arthroplasty may offer advantages over metal-backed components in terms of five-year survivorship, and stairs climbing score, this finding should be considered in the context of potential confounding factors. Nonetheless, based on the results, the all-polyethylene implant should be considered a viable choice for primary knee replacement.

Level of evidence
I.
A Large-Scale Application of the Stochastic Approach for Estimating the Shear Strength of Natural Rock Discontinuities
Authors: Jeffery M. , Huang J. , Fityus S. , Giacomini A. , Buzzi O. 
Published: May 2023

AbstractReliable shear strength determination of large in situ discontinuities is still a challenge faced by the rock mechanics field. This is principally due to the limited availability of surface roughness and morphology information of in situ discontinuities and the unresolved management of the ‘scale effect’ phenomenon. Recently, a stochastic approach for predicting the shear strength of large-scale discontinuities was established, encompassing random field theory, a semi-analytical shear strength model, and a stochastic analysis framework. A key aspect of the new approach is the application at field scale, thereby minimising or bypassing the scale effect. The approach has been validated at laboratory scale and an initial large-scale deterministic-based validation showed promising results. However, to date, no large-scale experimental-based validation has been undertaken. This paper presents the first rigorous application of the employed semi-analytical shear strength model and the stochastic approach on a 2 m-by-2 m discontinuity surface, with comparison of prediction to experimental shear strength data. The shear strength model was found to generally produce peak and residual predictions within a ± 10% relative error range, with good agreement between predicted and observed damage areas. It was observed that, applying the stochastic approach to seed traces with gradient statistics equivalent to that of the surface, produced predictions that closely resemble the experimental results. Whereas, predicting shear strength from different seed traces results in more variability of predictions, with many falling within ± 20% of the experimental data. The predictions of residual shear strength tended to be more accurate than peak shear strength.
Influence of the steel plate on the friction behavior of automotive wet disk clutches
Authors: Strobl P. , Schneider T. , Voelkel K. , Stahl K. 
Published: May 2023

AbstractFriction behavior is the key parameter for the design of automotive wet disk clutches. On the one hand, the Coefficient of Friction (CoF) level should be high to transmit torque efficiently. On the other hand, the clutch requires a positive slope of the CoF over sliding speed for good controllability, high comfort, and a low tendency to shudder. Clutches used in automatic or dual-clutch transmissions mostly use organic friction lining. These friction systems tend to have low CoF at low sliding speeds due to their high requirements regarding shifting comfort. Nevertheless, they show high values of CoF at high sliding speeds.This study investigates the influence of different steel plate finishes on friction behavior in different application-relevant operation modes such as brake shift, unsteady slip, and micro slip. Each of these operation modes requires an accurate CoF measurement at different sliding speed ranges. Therefore, we use different test rig setups. We characterize the steel plates by their areal surface topography measured with an optical system using focus variation. We discuss differences in the friction behavior of the corresponding tribological systems at different operating conditions.Results show an influence of the steel plate surface finish on the CoF level. Therefore, the surface finish of the steel plate influences the functional behavior of wet disk clutches and engineers should consider the surface finish in the early design phase. We discuss the correlation between commonly used surface parameters and friction parameters.
Safety and efficacy of edaravone in patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis
Authors: Nourelden Anas Zakarya , Kamal Ibrahim , Hagrass Abdulrahman Ibrahim , Tawfik Abdelrahman G. , Elhady Mahmoud M. , Fathallah Ahmed Hashem , Eshag Mona Muhe Eldeen , Zaazouee Mohamed Sayed 
Published: May 2023

Abstract
Aim

The study aims to increase understanding of edaravone’s efficacy and safety as an amyotrophic lateral sclerosis (ALS) treatment and provide significant insights regarding this field’s future research.

Methods
We conducted a comprehensive search of the Embase, PubMed, Cochrane Library, Web of Science, and Scopus databases for randomized controlled trials and observational studies up until September 2022. We evaluated the studies’ quality using the Cochrane risk of bias tool and the National Institutes of Health tool.

Results
We included 11 studies with 2845 ALS patients. We found that edaravone improved the survival rate at 18, 24, and 30 months (risk ratio (RR) = 1.03, 95% confidence interval (CI) [1.02 to 1.24], P = 0.02), (RR = 1.22, 95% CI [1.06 to 1.41], P = 0.007), and (RR = 1.17, 95% CI [1.01 to 1.34], P = 0.03), respectively. However, the administration of edaravone did not result in any significant difference in adverse effects or efficacy outcomes between the two groups, as indicated by a P value greater than 0.05.

Conclusion
Edaravone improves survival rates of ALS patients at 18, 24, and 30 months with no adverse effects. However, edaravone does not affect functional outcomes. In order to ensure the validity of our findings and assess the results in accordance with the disease stage, it is essential to carry out additional prospective, rigorous, and high-quality clinical trials. The current study offers preliminary indications regarding the effectiveness and safety of edaravone. However, further comprehensive research is required to establish the generalizability and sustainability of the findings.
Three-fold Fay–Herriot model for small area estimation and its diagnostics
Authors: Marcis Laura , Morales Domingo , Pagliarella Maria Chiara , Salvatore Renato 
Published: May 2023

AbstractThis paper introduces a three-fold Fay–Herriot model with random effects at three hierarchical levels. Small area best linear unbiased predictors of linear indicators are derived from the new model and the corresponding mean squared errors are approximated and estimated analytically and by parametric bootstrap. The problem of influence analysis and model diagnostics is addressed by introducing measures adapted to small area estimation. Simulation experiments empirically investigate the behavior of the predictors and mean squared error estimators. The new statistical methodology is applied to Spanish living conditions survey of 2004–2008. The target is the estimation of proportions of women and men under the poverty line by province and year.
RLSS: real-time, decentralized, cooperative, networkless multi-robot trajectory planning using linear spatial separations
Authors: Şenbaşlar Baskın , Hönig Wolfgang , Ayanian Nora 
Published: May 2023

AbstractTrajectory planning for multiple robots in shared environments is a challenging problem especially when there is limited communication available or no central entity. In this article, we present Real-time planning using Linear Spatial Separations, or RLSS: a real-time decentralized trajectory planning algorithm for cooperative multi-robot teams in static environments. The algorithm requires relatively few robot capabilities, namely sensing the positions of robots and obstacles without higher-order derivatives and the ability of distinguishing robots from obstacles. There is no communication requirement and the robots’ dynamic limits are taken into account. RLSS generates and solves convex quadratic optimization problems that are kinematically feasible and guarantees collision avoidance if the resulting problems are feasible. We demonstrate the algorithm’s performance in real-time in simulations and on physical robots. We compare RLSS to two state-of-the-art planners and show empirically that RLSS does avoid deadlocks and collisions in forest-like and maze-like environments, significantly improving prior work, which result in collisions and deadlocks in such environments.
Nitrogen deposition further increases Ambrosia trifida root exudate invasiveness under global warming
Authors: Xu Ke , Liu Xinyue , Zhao Changxin , Pan Qingmin , Chen Xiaoxing , Jiang Ning , Du Cuiping , Xu Yufeng , Shao Meini , Qu Bo 
Published: May 2023

Abstract
Invasive plants can change the soil ecological environment in the invasion area to adapt to their growth and reproduction through root exudates. Root exudates are the most direct manifestation of plant responses to external environmental changes, but there is a lack of studies on root exudates of invasive plants in the context of inevitable global warming and nitrogen deposition. In this research, we used widely targeted metabolomics to investigate Ambrosia trifida root exudates during seedling and maturity under warming and nitrogen deposition to reveal the possible mechanisms of A. trifida adaptation to climate change. The results showed that the organic acids increased under warming condition but decreased after nitrogen addition in the seedling stage. Phenolic acids increased greatly after nitrogen addition in the mature stage. Most phenolic acids were annotated in the phenylpropane metabolic pathway and tyrosine metabolism. Therefore, nitrogen deposition may increase the adaptability of A. trifida through root exudates, making it more invasive under global warming. The results provide new ideas for preventing and controlling the invasion of A. trifida under climate change.
Barriers and facilitators for the implementation of the CombiConsultation by general practitioners, pharmacists and practice nurses: a qualitative interview study
Authors: Meijvis Valérie A. M. , Heringa Mette , Kwint Henk-Frans , de Wit Niek J. , Bouvy Marcel L. 
Published: May 2023

Abstract
Background
The CombiConsultation is a consultation with the pharmacist for patients with a chronic condition, aligned with the periodic consultation with the practice nurse or general practitioner. Implementation requires adjustments in the working methods of these healthcare providers and therefore behavioural changes.

Aim
The aim of this study was to identify the barriers and facilitators that determine the behavioural changes by pharmacists, general practitioners and practice nurses required for the implementation of the CombiConsultation.

Method
Ten community pharmacists, 5 practice nurses and 5 general practitioners were sampled from practices enrolled in the CombiConsultation study. Their views regarding the implementation of this clinical pharmacy service were explored using interviews based on the 14 domains of the Theoretical Domains Framework (TDF), which are linked to the Capability-Opportunity-Motivation-Behaviour-model. Barriers and facilitators in the domains were assessed by content analysis.

Results
Twelve barriers and 23 facilitators were found within 13 TDF domains with high agreement between the healthcare providers. Important facilitators for implementation were the pharmacists’ expertise in pharmacotherapy (capability), access to medical data and physical proximity between professional practices (opportunity). Barriers were pharmacists’ insufficient consultation- and clinical-reasoning skills (capability), insufficient staff (opportunity) and reimbursement and lack of coordination among all involved healthcare providers (motivation).

Conclusion
All healthcare providers are motivated to implement the CombiConsultation. An existing collaborative practice, with a clear and accepted professional role of the pharmacist is essential. Training of pharmacists in consultation and clinical-reasoning skills can be beneficial, as well as arrangements on the consultation logistics, and reimbursement.
Parameterised response zero intelligence traders
Authors: Cliff Dave 
Published: May 2023

AbstractI introduce parameterised response zero intelligence (PRZI), a new form of zero intelligence (ZI) trader intended for use in simulation studies of the dynamics of continuous double auction markets. Like Gode and Sunder’s classic ZIC trader, PRZI generates quote prices from a random distribution over some specified domain of discretely valued allowable quote prices. Unlike ZIC, which uses a uniform distribution to generate prices, the probability distribution in a PRZI trader is parameterised in such a way that its probability mass function (PMF) is determined by a real-valued control variable s in the range $$[-1.0, +1.0]$$

[
-
1.0
,
+
1.0
]

that determines the strategy for that trader. When $$s=0$$

s
=
0

, a PRZI trader behaves identically to the ZIC strategy, with a uniform PMF; but when $$s \approx \pm 1$$

s
≈
±
1

the PRZI trader’s PMF becomes maximally skewed to one extreme or the other of the price range, thereby making it more or less “urgent” in the prices that it generates, biasing the quote price distribution towards or away from the trader’s limit price. To explore the co-evolutionary dynamics of populations of PRZI traders that dynamically adapt their strategies, I show initial results from long-term market experiments in which each trader uses a simple stochastic hill-climber algorithm to repeatedly evaluate alternative s-values and choose the most profitable at any given time. In these experiments the profitability of any particular s-value may be non-stationary because the profitability of one trader’s strategy at any one time can depend on the mix of strategies being played by the other traders at that time, which are each themselves continuously adapting. Results from these market experiments demonstrate that the population of traders’ strategies can exhibit rich dynamics, with periods of stability lasting over hundreds of thousands of trader interactions interspersed by occasional periods of change. Python source code for PRZI traders, and for the stochastic hill-climber, have been made publicly available on GitHub.
A Statistical Mechanics Approach to Describe Cell Reorientation Under Stretch
Authors: Loy N. , Preziosi L. 
Published: May 2023

AbstractExperiments show that when a monolayer of cells cultured on an elastic substratum is subject to a cyclic stretch, cells tend to reorient either perpendicularly or at an oblique angle with respect to the main stretching direction. Due to stochastic effects, however, the distribution of angles achieved by the cells is broader and, experimentally, histograms over the interval$$[0^\circ , 90^\circ ]$$[0∘,90∘]are usually reported. Here we will determine the evolution and the stationary state of probability density functions describing the statistical distribution of the orientations of the cells using Fokker–Planck equations derived from microscopic rules for describing the reorientation process of the cell. As a first attempt, we shall use a stochastic differential equation related to a very general elastic energy that the cell tries to minimize and, we will show that the results of the time integration and of the stationary state of the related forward Fokker–Planck equation compare very well with experimental results obtained by different researchers. Then, in order to model more accurately the microscopic process of cell reorientation and to shed light on the mechanisms performed by cells that are subject to cyclic stretch, we consider discrete in time random processes that allow to recover Fokker–Planck equations through classical tools of kinetic theory. In particular, we shall introduce a model of reorientation as a function of the rotation angle as a result of an optimal control problem. Also in this latter case the results match very well with experiments.
Reaction Mechanisms During Melting of H-DRI Focusing on Slag Formation and the Behavior of Vanadium
Authors: Vickerfält Amanda , Huss Joar , Martinsson Johan , Sichen Du 
Published: May 2023

AbstractThe reaction mechanisms during melting of hydrogen direct reduced iron pellets (H-DRI) with different degrees of reduction were studied experimentally at 1773 K to 1873 K at different times (60 to 600 seconds), focusing on the autogenous slag formation. It was found that an autogenous slag is formed inside the pellets prior to the melting of the metal phase. The formation of the autogenous slag started with the melting of FeO, initially located in the center of the iron grains. The liquid FeO flowed into the pore network of the pellet. While flowing, the liquid FeO dissolved parts of the residual oxides, forming an autogenous slag. The slag stayed in the pore network until the iron was molten. Upon melting of the iron, the slag coalesced into spherical droplets. The final state is reached upon the separation of the metal and slag phases by flotation, as a bulk slag was formed on the surface of the liquid iron. In addition, since the iron ore used in this study contains vanadium, the behavior of V was discussed separately based on the experimental observations to build a basis for future studies on V extraction.
Recent advances in transamidation of unactivated amides
Authors: Kumar Vishal , Dhawan Sanjeev , Bala Renu , Girase Pankaj S. , Singh Parvesh , Karpoormath Rajshekhar 
Published: May 2023

AbstractIn recent years, transamidation has been an essential topic in the formation of amide bonds over the conventional route due to chemoselectivity and greenside products. So many groups have disclosed new amide transformation techniques. Transamidation is typically classified into two categories based on amide activation: activated amide and unactivated amide. We conducted a review of the pertinent literature that discusses the cross amidation reactions of unactivated amides employing a variety of reagents, enabling contemporary research professionals to overcome synthetic barriers.
Graphical abstract
Biomarkers of exposure and potential harm in exclusive users of electronic cigarettes and current, former, and never smokers
Authors: Haswell Linsey E. , Gale Nathan , Brown Elaine , Azzopardi David , McEwan Michael , Thissen Jesse , Meichanetzidis Filimon , Hardie George 
Published: May 2023

AbstractElectronic cigarette (EC) aerosol emissions generally contain fewer and lower concentrations of harmful and potentially harmful constituents, compared with cigarette smoke. Further studies are needed to establish whether decreased emissions translate to reduced health risks for EC users. In a cross-sectional study, biomarkers of exposure (BoE) to certain tobacco smoke toxicants and biomarkers of potential harm (BoPH), associated with biological processes linked to the potential development of smoking-related diseases and oxidative stress, were assessed in solus Vuse ECs users and current, former, and never smokers. In total, 213 participants were enrolled, and smoking status was confirmed by urinary cotinine, exhaled carbon monoxide, and N-(2-cyanoethyl)valine levels (EC users and former smokers only). During confinement participants used their usual product (EC or cigarette) as normal and BoE and BoPHs were assessed via blood, 24-h urine, and physiological assessment. Significantly lower levels of all urinary BoE; MHBMA, HMPMA, 3-HPMA, NNN, 3-OH-B[a]P, S-PMA, NNAL (all p < 0.0001), and TNeq (p = 0.0074) were observed in EC users when compared with smokers. Moreover, significantly lower levels were observed in EC users for 3 of the 7 BoPH measured, carboxyhaemoglobin (p < 0.0001), soluble intercellular adhesion molecule-1 (p = 0.0028), and 11-dehydrothromboxane B2 (p = 0.0012), when compared with smokers. As compared with smokers, solus Vuse EC users have significantly lower exposure to tobacco toxicants for the BoE, and 3 BoPH measured. These results add to the weight of evidence supporting EC as part of a tobacco harm reduction strategy.
Gut inflammation and tumorigenesis: every site has a different tale to tell
Authors: Vanoli Alessandro , Parente Paola , Fassan Matteo , Mastracci Luca , Grillo Federica 
Published: May 2023

AbstractGut inflammation has been correlated with cancerogenesis by disrupting gastrointestinal homeostasis. Numerous chronic inflammatory disorders of the tubular gastrointestinal tract (e.g., gastroesophageal reflux disease, Helicobacter pylori-induced and autoimmune chronic gastritis, celiac disease, and inflammatory bowel diseases) have been variably associated with an increased neoplastic risk. Gastrointestinal inflammation-induced neoplasms include epithelial tumors (esophageal squamous cell carcinoma and adenocarcinoma, gastric adenocarcinoma and neuroendocrine tumors, small bowel adenocarcinoma and neuroendocrine tumors, and colorectal cancer) and lymphomas (such as gastric marginal zone lymphomas and enteropathy-associated T cell lymphoma). In the last decades, numerous studies have investigated the pathogenetic mechanisms and the microenvironmental/microbiome changes that trigger genetic and/or epigenetic alterations eventually leading to tumorigenesis, often through a histologically recognizable inflammation-dysplasia-carcinoma cancerogenic sequence. In the present review, an overview of the current knowledge on the links between inflammatory diseases and neoplasms of the tubular GI tract, applying a site-by-site approach, is provided.