bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two‐Dimensional Mg2Si Nanosheet‐Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin
Authors: Zhu Yanxia , Jiang Qi , Jin Zhaokui , Chen Danyang , Xu Qingqing , Chen Jinchun , Zeng Yue , Chen Shengqiang , He Qianjun 
Published: December 2022

AbstractMolecular hydrogen holds a high potential for wound healing owing to its anti‐inflammatory effect and high biosafety, but commonly used hydrogen administration routes hardly achieve the sustained supply of high‐dosage hydrogen, limiting hydrogen therapy efficacy. Here, two‐dimensional Mg2Si nanosheet (MSN) is exploited as a super‐persistent hydrogen‐releasing nanomaterial with high biocompatibility, and the incorporation of MSN into the chitosan/hyaluronic acid hydrogel (MSN@CS/HA) is developed as a dressing to repair deeply burned skin. The MSN@CS/HA hydrogel dressing can continuously generate hydrogen molecules for about 1 week in the physiological conditions in support of local, long‐term, and plentiful hydrogen supply and remarkably promotes the healing and regeneration of deep second‐degree and third‐degree burn wounds without visible scar and toxic side effect. Mechanistically, a sustained supply of hydrogen molecules induces anti‐inflammatory M2 macrophage polarization in time by enhancing CCL2 (chemokine C‐C motif ligand 2) expression to promote angiogenesis and reduce fibrosis and also enhances the proliferation and migration capability of skin cells directly and indirectly by locally scavenging overexpressed reactive oxygen species, synergistically favoring wound repair. The proposed synthesis method, therapeutic strategy, and mechanisms will open a window for synthesizing a variety of MSene nanomaterials and developing their various proangiogenesis applications besides wound healing.
A unique coincidence of a 17q12 deletion and duplication in a Czech family led to a refined genotype–phenotype correlation
Authors: Zunova Hana , Stolfa Miroslav , Kunikova Tereza , Novotna Drahuse , Valkovicova Radka , Štěrbová Katalin , Vlckova Marketa 
Published: December 2022

AbstractChromosomal band 17q12 is a gene‐rich region flanked by segmental duplications, making the region prone to deletions and duplications via the non‐allelic homologous recombination mechanism. While deletions cause a well‐described disorder with a specific phenotype called renal cysts and diabetes mellitus, the phenotype caused by reciprocal duplications is less specific, primarily because of variable expressivity, and incomplete penetrance. We present an unusual family with four children carrying the 17q12 microduplication inherited from their clinically healthy mother, who was a carrier of both the duplication and, interestingly, also of an atypical deletion of the 17q12 region. The duplication was inherited from her diabetic father and the deletion from her diabetic mother who also suffered from a renal disorder. Clinical manifestations in the family were variable, but all children showed some degree of a neurodevelopmental disorder, such as epilepsy, intellectual disability, delayed speech development, or attention deficit disorder. The simultaneous occurrence of a deletion and duplication in the same chromosomal region in one family is very rare, and to our knowledge, individuals carrying both a deletion and a duplication of this region have never been described.
Copper‐Catalyzed Cross‐Coupling Reaction of α‐Halo‐N‐Tosylhydrazones with H‐Phosphoryl Compounds to Afford Alkenylphosphoryl Compounds
Authors: Shen Ruwei , Yin Kaixin , Fan Yishuai 
Published: December 2022

AbstractThe copper‐catalyzed reaction of α‐halo‐N‐tosylhydrazones with H‐phosphoryl compounds is reported to afford alkenylphosphoryl compounds in modest to good yields. The reaction may take place via a copper‐promoted Bamford‐Stevens‐type reaction of an α‐phosphorylated diazo intermediate. The diazo intermediate is trapped by an excess H‐phosphoryl compound to give α, N‐bisphosphoryl hydrazone in the absence of a copper catalyst.
Histological and magnetic resonance imaging assessment of Liqoseal in a spinal in vivo pig model
Authors: Slot Emma M. H. , Bergmann Wilhelmina , Kinaci Ahmet , de Boer Bart , Moayeri Nizar , Redegeld Saskia , van Thoor Sander , van Doormaal Tristan P. C. 
Published: December 2022

AbstractBackgroundLiqoseal (Polyganics, B.V.) is a dural sealant patch for preventing postoperative cerebrospinal fluid (CSF) leakage. It has been extensively tested preclinically and CE (Conformité Européenne) approved for human use after a first cranial in‐human study. However, the safety of Liqoseal for spinal application is still unknown. The aim of this study was to assess the safety of spinal Liqoseal application compared with cranial application using histology and magnetic resonance imaging characteristics.MethodsEight female Dutch Landrace pigs underwent laminectomy, durotomy with standard suturing and Liqoseal application. Three control animals underwent the same procedure without sealant application. The histological characteristics and imaging characteristics of animals with similar survival times were compared to data from a previous cranial porcine model.ResultsSimilar foreign body reactions were observed in spinal and cranial dura. The foreign body reaction consisted of neutrophils and reactive fibroblasts in the first 3 days, changing to a chronic granulomatous inflammatory reaction with an increasing number of macrophages and lymphocytes and the formation of a fibroblast layer on the dura by day 7. Mean Liqoseal plus dura thickness reached a maximum of 1.2 mm (range 0.7–2.0 mm) at day 7.ConclusionThe spinal dural histological reaction to Liqoseal during the first 7 days was similar to the cranial dural reaction. Liqoseal did not swell significantly in both application areas over time. Given the current lack of a safe and effective dural sealant for spinal application, we propose that an in‐human safety study of Liqoseal is the logical next step.
Patient‐derived xenograft model in colorectal cancer basic and translational research
Authors: Liu Xiaofeng , Xin Zechang , Wang Kun 
Published: December 2022

AbstractColorectal cancer (CRC) is one of the most popular malignancies globally, with 930 000 deaths in 2020. The evaluation of CRC‐related pathogenesis and the discovery of potential therapeutic targets will be meaningful and helpful for improving CRC treatment. With huge efforts made in past decades, the systematic treatment regimens have been applied to improve the prognosis of CRC patients. However, the sensitivity of CRC to chemotherapy and targeted therapy is different from person to person, which is an important cause of treatment failure. The emergence of patient‐derived xenograft (PDX) models shows great potential to alleviate the straits. PDX models possess similar genetic and pathological characteristics as the features of primary tumors. Moreover, PDX has the ability to mimic the tumor microenvironment of the original tumor. Thus, the PDX model is an important tool to screen precise drugs for individualized treatment, seek predictive biomarkers for prognosis supervision, and evaluate the unknown mechanism in basic research. This paper reviews the recent advances in constructed methods and applications of the CRC PDX model, aiming to provide new knowledge for CRC basic research and therapeutics.
Mechanistic Insight into Peptidyl‐Cysteine Oxidation by the Copper‐Dependent Formylglycine‐Generating Enzyme
Authors: Wu Yao , Zhao Cong , Su Yanzhuang , Shaik Sason , Lai Wenzhen 
Published: December 2022

AbstractThe copper‐dependent formylglycine‐generating enzyme (FGE) catalyzes the oxygen‐dependent oxidation of specific peptidyl‐cysteine residues to formylglycine. Our QM/MM calculations provide a very likely mechanism for this transformation. The reaction starts with dioxygen binding to the tris‐thiolate CuI center to form a triplet CuII‐superoxide complex. The rate‐determining hydrogen atom abstraction involves a triplet‐singlet crossing to form a CuII−OOH species that couples with the substrate radical, leading to a CuI‐alkylperoxo intermediate. This is accompanied by proton transfer from the hydroperoxide to the S atom of the substrate via a nearby water molecule. The subsequent O−O bond cleavage is coupled with the C−S bond breaking that generates the formylglycine and a CuII‐oxyl complex. Moreover, our results suggest that the aldehyde oxygen of the final product originates from O2, which will be useful for future experimental work.
Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared‐II Imaging and Rapid Inactivation of Coronavirus
Authors: Liu Yishen , Gu Meijia , Ding Qihang , Zhang Zhiyun , Gong Wanxia , Yuan Yuncong , Miao Xiaofei , Ma Huili , Hong Xuechuan , Hu Wenbo , Xiao Yuling 
Published: December 2022

AbstractDespite significant effort, a majority of heavy‐atom‐free photosensitizers have short excitation wavelengths, thereby hampering their biomedical applications. Here, we present a facile approach for developing efficient near‐infrared (NIR) heavy‐atom‐free photosensitizers. Based on a series of thiopyrylium‐based NIR‐II (1000–1700 nm) dyads, we found that the star dyad HD with a sterically bulky and electron‐rich moiety exhibited configuration torsion and significantly enhanced intersystem crossing (ISC) compared to the parent dyad. The electron excitation characteristics of HD changed from local excitation (LE) to charge transfer (CT)‐domain, contributing to a ≈6‐fold reduction in energy gap (ΔEST), a ≈10‐fold accelerated ISC process, and a ≈31.49‐fold elevated reactive oxygen species (ROS) quantum yield. The optimized SP@HD‐PEG2K lung‐targeting dots enabled real‐time NIR‐II lung imaging, which precisely guided rapid pulmonary coronavirus inactivation.
Long‐Range Cationic Disordering Induces two Distinct Degradation Pathways in Co‐Free Ni‐Rich Layered Cathodes
Authors: Hua Weibo , Zhang Jilu , Wang Suning , Cheng Yi , Li Hang , Tseng Jochi , Wu Zhonghua , Shen Chong‐Heng , Dolotko Oleksandr , Liu Hao , Hung Sung‐Fu , Tang Wei , Li Mingtao , Knapp Michael , Ehrenberg Helmut , Indris Sylvio , Guo Xiaodong 
Published: December 2022

AbstractNi‐rich layered oxides are one of the most attractive cathode materials in high‐energy‐density lithium‐ion batteries, their degradation mechanisms are still not completely elucidated. Herein, we report a strong dependence of degradation pathways on the long‐range cationic disordering of Co‐free Ni‐rich Li1−m(Ni0.94Al0.06)1+mO2 (NA). Interestingly, a disordered layered phase with lattice mismatch can be easily formed in the near‐surface region of NA particles with very low cation disorder (NA‐LCD, m≤0.06) over electrochemical cycling, while the layered structure is basically maintained in the core of particles forming a “core–shell” structure. Such surface reconstruction triggers a rapid capacity decay during the first 100 cycles between 2.7 and 4.3 V at 1 C or 3 C. On the contrary, the local lattice distortions are gradually accumulated throughout the whole NA particles with higher degrees of cation disorder (NA‐HCD, 0.06≤m≤0.15) that lead to a slow capacity decay upon cycling.
Cooperative Catalysis of Polysulfides in Lithium‐Sulfur Batteries through Adsorption Competition by Tuning Cationic Geometric Configuration of Dual‐active Sites in Spinel Oxides
Authors: Li Hongtai , Shi Pei , Wang Lei , Yan Tianran , Guo Tong , Xia Xiao , Chen Chi , Mao Jing , Sun Dan , Zhang Liang 
Published: December 2022

AbstractFundamentally understanding the structure–property relationship is critical to design advanced electrocatalysts for lithium‐sulfur (Li−S) batteries, which remains a formidable challenge. Herein, by manipulating the regulable cations in spinel oxides, their geometrical‐site‐dependent catalytic activity for sulfur redox is investigated. Experimental and theoretical analyses validate that the modulation essence of cooperative catalysis of lithium polysulfides (LiPSs) is dominated by LiPSs adsorption competition between Co3+tetrahedral (Td) and Mn3+octahedral (Oh) sites on Mn3+Oh−O−Co3+Tdbackbones. Specifically, high‐spin Co3+Tdwith stronger Co−S covalency anchors LiPSs persistently, while electron delocalized Mn3+Ohwith adsorptive orbital (dz2) functions better in catalyzing specialized LiPSs conversion. This work inaugurates a universal strategy for sculpting geometrical configuration to achieve charge, spin, and orbital topological regulation in electrocatalysts for Li−S batteries.
Transition‐Metal‐Free Difunctionalization of Sulfur Nucleophiles**
Authors: Mondal Shobhan , Di Tommaso Ester Maria , Olofsson Berit 
Published: December 2022

AbstractEfficient protocols for accessing iodo‐substituted diaryl and aryl(vinyl) sulfides have been developed using iodonium salts as reactive electrophilic arylation and vinylation reagents. The reactions take place under transition‐metal‐free conditions, employing odorless and convenient sulfur reagents. A wide variety of functional groups are tolerated in theS‐diarylation, enabling the regioselective late‐stage application of several heterocycles and drug molecules under mild reaction conditions. A novelS‐difunctionalization pathway was discovered using vinyliodonium salts, which proceeds under additive‐free reaction conditions and grants excellent stereoselectivity in the synthesis of aryl(vinyl) sulfides. A one‐pot strategy combining transition‐metal‐free diarylation and subsequent reduction provided facile access to electron‐rich thioanilines and a direct synthesis of a potential drug candidate derivative. The retained iodo group allows a wide array of further synthetic transformations. Mechanistic insights were elucidated by isolating the key intermediate, and the relevant energy profile was substantiated by DFT calculations.
Benzotrithiophene‐based Covalent Organic Framework Photocatalysts with Controlled Conjugation of Building Blocks for Charge Stabilization
Authors: Jeon Jong‐Pil , Kim Yu Jin , Joo Se Hun , Noh Hyuk‐Jun , Kwak Sang Kyu , Baek Jong‐Beom 
Published: December 2022

AbstractCovalent organic frameworks have recently shown high potential for photocatalytic hydrogen production. However, their structure‐property‐activity relationship has not been sufficiently explored to identify a research direction for structural design. Herein, we report the design and synthesis of four benzotrithiophene (BTT)‐based covalent organic frameworks (COFs) with different conjugations of building units, and their photocatalytic activity for hydrogen production. All four BTT‐COFs had slipped parallel stacking patterns with high crystallinity and specific surface areas. The change in the degree of conjugation was found to rationally tune the rate of photocatalytic hydrogen evolution. Based on the experimental and calculation results, the tunable photocatalytic performance could be mainly attributed to the electron affinity and charge trapping of the electron accepting units. This study provides important insights for designing covalent organic frameworks for efficient photocatalysts.
Enhancement of water and salt penetration resistance into mortar cement composited with vulcanized natural rubber compound
Authors: Jitkarune Inchalita , Manantapong Phattarasuda , Tangboriboon Nuchnapa 
Published: December 2022

AbstractVulcanized natural rubber compound plays an important role to be used as a reinforcement phase for mortar‐cement‐paste matrix. Natural rubber is an organic binder to increase good adhesion for the flexible‐film formation and waterproof membrane within the mortar matrix. Adding sulfur as a curing agent into natural rubber latex can increase chemical bridge bonding within the mortar cement paste matrix. Embedding vulcanized natural rubber 30 wt% (PMC‐30) with a sulfur curing system was employed to increase physical, chemical, thermal, and mechanical properties due to interconnective bonding. PMC‐30 possessed low water absorption of less than 10%. After 28 days of curing, they possessed a high thermal shock resistance, a low percentage of salt solution absorption, and no thermal deterioration. The mortar composite embedded with the vulcanized natural rubber compound 30 wt% (PMC‐30) was an alternative mortar composite formula suitable for use in the seawater, beaches, and salt contact areas due to the lowest percentage of salt solution absorption (1.94%), low water absorption (3.17% ± 0.74), good thermal shock resistance, and the highest flexural strength (6.72 ± 0.39 MPa). Therefore, adding the vulcanized natural rubber compound in mortar cement is a good way to improve the flexural strength and water resistance of mortar cement.
Influence of aviation hydraulic oil swelling on the mechanical properties of HNBR/EPDM vulcanizates reinforced by carbon black
Authors: Jiang Xingwang , Wang Chuan , Liu Susu , Wang Huiyu , Yu Jianghong , Liu Guangyong 
Published: December 2022

AbstractThe study on swelling behaviors of rubber products in liquid media is of great value for life prediction and practical application guidance. In this work, changes in the mechanical properties of hydrogenated nitrile rubber/ethylene propylene diene monomer (HNBR/EPDM) blends caused by swelling in aviation hydraulic oil YH‐15 were studied. Effects of two kinds of carbon black, N220, and N990, on the tensile properties of HNBR/EPDM blends at both unswollen and swollen states were investigated. The results turned out that N220 exhibited better reinforcing effects than N990 on HNBR/EPDM blends. The tensile properties of unfilled and filled HNBR/EPDM blends decreased rapidly at first and then tended to stabilize with the extension of swelling time in YH‐15, while the modulus at 100% declined firstly and then increased. After swelling for 72 h, the tensile strength of HNBR/EPDM blends filled with N220 decreased by more than 35%, and by comparison, it decreased by about 20% for the N990‐filled HNBR/EPDM blends. The cross‐sections of the tensile samples after swelling changed greatly compared with the unswollen samples. In addition, the effect of swelling on the hardness of the HNBR/EPDM blends was not obvious.
Thermodynamics of a scale‐invariant nonlinear sigma model
Authors: Ferrari Gabriel 
Published: December 2022

AbstractA recently developed variational resummation technique incorporating renormalization group properties has been shown to solve the scale dependence problem that plagues the evaluation of physical observables. This method is used in the present work to evaluate thermodynamical quantities within the two‐dimensional nonlinear sigma model, which shares some features with Yang‐Mills theories like asymptotic freedom, trace anomaly, and the nonperturbative generation of a mass gap. Besides the fact that nonperturbative results can be readily generated solely by considering lowest‐order contributions, we also show that its next‐to‐leading correction indicates convergence to the sought‐after scale invariance.
Maternal first trimester metabolic profile in pregnancies with transposition of the great arteries
Authors: Huida Johanna , Ojala Tiina , Ilvesvuo Johanna , Surcel Heljä‐Marja , Priest James R. , Helle Emmi 
Published: December 2022

AbstractBackgroundHigher maternal body mass index (BMI) and abnormal glucose metabolism during early pregnancy are associated with congenital heart defects in the offspring, but the exact mechanisms are unknown.MethodsWe evaluated the association between maternal first trimester metabolic profile and transposition of the great arteries (TGA) in the offspring in a matched case–control study with 100 TGA mothers and 200 controls born in Finland during 2004–2014. Cases and controls were matched by birth year, child sex, and maternal age and BMI. Serum samples collected between 10‐ and 14‐weeks of gestation were analyzed for 73 metabolic measures. Conditional logistic regression was used to assess the risk for TGA in the offspring, and a subgroup analysis among mothers with high BMI was conducted.ResultsHigher concentrations of four subtypes of extremely large very‐low‐density lipoprotein (VLDL) particles and one of large VLDL particles were observed in TGA mothers. This finding did not reach statistical significance after multiple testing correction. The pooled odds ratio (OR) of the all metabolic variables was slightly higher in TGA mothers in the subgroup with maternal BMI over 25 (OR 1.25) and significantly higher in the subgroup with maternal BMI over 30 (OR 1.95) compared to the original population (OR 1.18).ConclusionsOur findings indicate that an abnormal maternal early pregnancy metabolic profile might be associated with TGA in the offspring, especially in obese mothers. A trend indicating altered VLDL subtype composition in TGA pregnancies warrants further research.
Erfahrungen aus der Planung und Prüfung des Rückbaus von Großbrücken
Authors: Lingemann Jan , Sonnabend Stephan 
Published: December 2022

AbstractDer aktuelle Brückenbestand in Deutschland zeigt u. a. aufgrund des Alters der Bauwerke, der stark gestiegenen Verkehrslasteinwirkungen, des starken Einsatzes von Salz als Taumittel und aufgrund von Abweichung heutiger Bemessungsvorschriften zu früheren Regelwerken teilweise Mängel hinsichtlich des Bauwerkszustands und teilweise auch Defizite hinsichtlich der rechnerischen Tagfähigkeit. Im Zuge des Erhalts der Verkehrsinfrastruktur wurden bereits einige Brücken durch Neubauten ersetzt und auch in Zukunft werden zahlreiche Ersatzneubauten notwendig werden. Der hierbei erforderliche Rückbau von Großbrücken stellt eine komplexe Aufgabe dar. In den vergangenen Jahren wurden bereits einige Großbrücken erfolgreich zurückgebaut und durch Ersatzneubauten ersetzt. Im vorliegenden Beitrag werden ausgewählte statische Besonderheiten beim Rückbau von Großbrücken erläutert und Erfahrungen aus zurückliegenden Projekten aufgezeigt.
Drawn to the gloss: Examining the effect of product reflection on product aesthetics
Authors: Sharma Nazuk , Kumar Anand 
Published: December 2022

AbstractWhile advertising products with reflections is a common industry practice, this research is the first to investigate their impact on product aesthetics. Reflections are endowed with an inherent shine since they are naturally formed by the interaction of light with an object and a reflecting surface. We draw upon this property along with Evolutionary Psychology (EP) research documenting an intrinsic human attraction towards gloss to predict their positive effect on product aesthetics. Further in line with the EP principles, we propose that this effect is mediated by enhanced pristineness perceptions about the product in the presence of its reflection in the ad. Finally, we draw upon the Elaboration Likelihood Model (ELM) to identify product design complexity as a boundary condition for the positive effect of reflection on product attractiveness perceptions. For a product with relatively high (vs. low) design complexity, with design being the focal aspect that is elaborated via a central route, we predict the effect of a peripheral stylistic cue like product reflection to attenuate. Three experimentally designed studies employing different product types offer empirical support to these predictions. Our work extends prior marketing research studying the effects of executional elements in advertising on consumers' product reactions, particularly the aesthetic impact of product reflections as creative stylistic cues. The managerial implications of this work span both traditional and digital marketing channels. Incorporating a product reflection in advertising can work as an easy‐to‐implement option that can help practitioners elevate product pristineness and aesthetics. On the other hand, avoiding their use when advertising products with relatively complex designs can save both ad space and money.