bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin (IL)-1 Receptor Signaling Is Required for Complete Taste Bud Regeneration and the Recovery of Neural Taste Responses following Axotomy
Authors: Dong Guangkuo , Kogan Schuyler , Venugopal Natasha , Chang Eddy , He Lianying , Faal Fama , Shi Yang , Phillips McCluskey Lynnette 
Published: April 2023

Experimental or traumatic nerve injury causes the degeneration of associated taste buds. Unlike most sensory systems, the sectioned nerve and associated taste buds can then regenerate, restoring neural responses to tastants. It was previously unknown whether injury-induced immune factors mediate this process. The proinflammatory cytokines, interleukin (IL)-1α and IL-1β, and their requisite receptor are strongly expressed by anterior taste buds innervated by the chorda tympani nerve. We tested taste bud regeneration and functional recovery in mice lacking the IL-1 receptor. After axotomy, the chorda tympani nerve regenerated but was initially unresponsive to tastants in both WT andIl1r KOmice. In the absence ofIl1rsignaling, however, neural taste responses remained minimal even >8 weeks after injury in both male and female mice, whereas normal taste function recovered by 3 weeks in WT mice. Failed recovery was because of a 57.8% decrease in regenerated taste buds inIl1rKO compared with WT axotomized mice.Il1agene expression was chronically dysregulated, and the subset of regenerated taste buds were reinnervated more slowly and never reached full volume as progenitor cell proliferation lagged in KO mice.Il1rsignaling is thus required for complete taste bud regeneration and the recovery of normal taste transmission, likely by impairing taste progenitor cell proliferation. This is the first identification of a cytokine response that promotes taste recovery. The remarkable plasticity of the taste system makes it ideal for identifying injury-induced mechanisms mediating successful regeneration and recovery.SIGNIFICANCE STATEMENTTaste plays a critical role in nutrition and quality of life. The adult taste system is highly plastic and able to regenerate following the disappearance of most taste buds after experimental nerve injury. Several growth factors needed for taste bud regeneration have been identified, but we demonstrate the first cytokine pathway required for the recovery of taste function. In the absence of IL-1 cytokine signaling, taste bud regeneration is incomplete, preventing the transmission of taste activity to the brain. These results open a new direction in revealing injury-specific mechanisms that could be harnessed to promote the recovery of taste perception after trauma or disease.
c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD
Authors: Sahana Talanjeri Gopalakrishna , Chase Katherine Johnson , Liu Feilin , Lloyd Thomas E. , Rossoll Wilfried , Zhang Ke 
Published: April 2023

Stress granules are the RNA/protein condensates assembled in the cells under stress. They play a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, how stress granule assembly is regulated and related to ALS/FTD pathomechanism is incompletely understood. Mutation in the C9orf72 gene is the most common cause of familial ALS and FTD. C9orf72 mutation causes the formation of toxic dipeptide repeats. Here we show that the two most toxic dipeptide repeats [i.e., poly(GR) and poly(PR)] activate c-Jun N-terminal kinase (JNK) via the ER-stress response protein IRE1 using fly and cellular models. Further, we show that activated JNK promotes stress granule assembly in cells by promoting the transcription of one of the key stress granule proteins (i.e., G3BP1) by inducing histone 3 phosphorylation. Consistent with these findings, JNK or IRE1 inhibition reduced stress granule formation, histone 3 phosphorylation, G3BP1 mRNA and protein levels, and neurotoxicity in cells overexpressing poly(GR) and poly(PR) or neurons derived from male and female C9ALS/FTD patient-induced pluripotent stem cells. Our findings connect ER stress, JNK activation, and stress granule assembly in a unified pathway contributing to C9ALS/FTD neurodegeneration.SIGNIFICANCE STATEMENTc-Jun N-terminal kinase (JNK) is a part of the mitogen-activated protein kinase pathway, which is the central node for the integration of multiple stress signals. Cells are under constant stress in neurodegenerative diseases, and how these cells respond to stress signals is a critical factor in determining their survival or death. Previous studies have shown JNK as a major contributor to cellular apoptosis. Here, we show the role of JNK in stress granule assembly. We identify that toxic dipeptide repeats produced in ALS/FTD conditions activate JNK. The activated JNK in the nucleus can induce histone modifications which increase G3BP1 expression, thus promoting stress granule assembly and neurodegeneration.
Extreme Attachment
Authors: McKeever Gerard Lee 
Published: April 2023

Gerard Lee McKeever, “Extreme Attachment: Allan Cunningham’s ‘South Countree’” (pp. 223–252)
This article positions Allan Cunningham (1784–1842) as an extreme case of literary place-making in the first half of the nineteenth century. Cunningham lived from 1810 in London, where he became superintendent of the sculptor Francis Chantrey’s workshop. Yet over the following decades, he produced literary work that is remarkably consistent in its return to his native southwest Scotland and the Anglo-Scottish borders region, developing a longue durée imaginative geography through a rotating cast of characters, places, tales, and topoi. This work emblematizes a moment in the transformation of the long-eighteenth-century condition of “nostalgia,” or homesickness, which over the course of the nineteenth century became a patriotic virtue and—eventually—an aestheticized sense of the past. The article interrogates Cunningham’s overall literary career from a geographical perspective, before focusing in on two unfairly neglected later works: the long poem The Maid of Elvar (1832) and his final novel, Lord Roldan (1836). In general, Cunningham’s work performs regional attachment in such a precariously literary manner that it forces the reader to reckon with the imaginative quality of belonging. By the 1830s, however, it had reached an acutely self-referential phase, exercising and recycling a vocabulary of belonging that had been decades in the making.
Characterization of Birth Hospitalizations in the United States
Authors: Ding Lucky , Rodean Jonathan , Leyenaar JoAnna K. , Coon Eric R. , Mahant Sanjay , Gill Peter J. , Cabana Michael D. , Kaiser Sunitha V. 
Published: April 2023

OBJECTIVES
A broad understanding of the scope of birth hospitalizations in the United States is lacking. We aimed to describe the demographics and location of birth hospitalizations in the United States and rank the most common and costly conditions documented during birth hospitalizations.

METHODS
We conducted a cross-sectional analysis of the 2019 Kids’ Inpatient Database, a nationally-representative administrative database of pediatric discharges. All hospitalizations with the indicator “in-hospital birth” and any categorized by the Pediatric Clinical Classification System as “liveborn” were included. Discharge-level survey weights were used to generate nationally-representative estimates. Primary and secondary conditions coded during birth hospitalizations were categorized using the Pediatric Clinical Classification System, rank-ordered by total prevalence and total marginal costs (calculated using design-adjusted lognormal regression).

RESULTS
In 2019, there were an estimated 5 299 557 pediatric hospitalizations in the US and 67% (n = 3 551 253) were for births, totaling $18.1 billion in cost. Most occurred in private, nonprofit hospitals (n = 2 646 685; 74.5%). Prevalent conditions associated with birth admissions included specified conditions originating in the perinatal period (eg, pregnancy complications, complex births) (n = 1 021 099; 28.8%), neonatal hyperbilirubinemia (n = 540 112; 15.2%), screening or risk for infectious disease (n = 417 421; 11.8%), and preterm newborn (n = 314 288; 8.9%). Conditions with the highest total marginal costs included specified conditions originating in perinatal period ($168.7 million) and neonatal jaundice with preterm delivery ($136.1 million).

CONCLUSIONS
Our study details common and costly areas of focus for future quality improvement and research efforts to improve care during term and preterm infant birth hospitalizations. These include hyperbilirubinemia, infectious disease screening, and perinatal complications.
Intraoperative characteristics of somatotropinomas
Authors: Pletnev R.  V. , Cherebillo V. Yu. , Shatilova A. S. , Bayramova S. A. 
Published: April 2023

Background. Acromegaly is a rare disease associated with insulin‑like growth factor 1 hyperproduction due to the presence of pituitary adenoma in the patient. The first‑line treatment of such patients is surgical removal of the formation in order to normalize hormonal status. The main predictors of the ineffectiveness of surgical treatment and relapse of the disease are large tumor size, tumor invasion into the cavernous sinus, and high preoperative levels of growth hormone, as well as Ki‑6 % expression. The search for additional risk factors for disease recurrence, which according to various sources is approximately 30 % after primary surgical treatment, is an urgent task for researchers. In our work, we studied the intraoperative characteristics of the tumor, size of pituitary adenomas according to preoperative magnetic resonance imaging of the brain, degree of invasion of the tumor into the cavernous sinus according to the Knosp classification and compared them with disease outcomes after a year of follow‑up after surgical treatment.Aim. To identify new markers of aggressive progression of pituitary tumors.Materials and methods. A retrospective analysis of medical documentation, protocols of operations of 90 patients aged between 19 and 73 years with the diagnosis of growth hormone‑secreting pituitary adenoma was performed. The dia gnosis was confirmed based on clinical picture, laboratory and instrumental examination methods. All patients underwent endoscopic transsphenoidal removal of pituitary adenoma by one surgeon in one medical institution between 2017 and 2019.Results. Intraoperative characteristics of the tumor, such as the color of the solid component, density, degree of vascularization were compared with the results of laboratory and instrumental data, as well as the results of surgical treatment after a year of follow‑up.Conclusion. Such intraoperative characteristics of growth hormone‑secreting pituitary adenomas as the purplish‑gray color of the solid component, high vascularization, as well as dense‑elastic consistency of the tumor, can be considered high risk factors for continued tumor growth in the first 6 months after surgical treatment or relapse of the disease during a year of follow‑up.
Radiofrequency ablation of epileptogenic periventricular heterotopia
Authors: Guzeeva A. S. , Denisova N. P. , Dmitriev A. B. , Khalepa A. A. , Zubok N. A. , Efremov F.  A. 
Published: April 2023

Background. Periventricular heterotopia is one of the causes of the intractable epilepsy. Different treatments of this pathology show variable efficacy.Aim. To present the result of radiofrequency ablation of periventricular heterotopia in a patient with drug‑resistant epilepsy.Materials and methods. 33‑year‑old female patient has been suffering from epilepsy since the age of 19 with frequent focal seizures (up to 70–80 times a month) and bilateral tonic‑clonic seizures (up to 4–6 times a year). In 2018 the patient underwent resection of the right temporal lobe with its medial structures and partial resection of the periventricular heterotopia located in the right lateral ventricle. The frequency of focal seizures after 1st surgical treatment increased till 150 per month, bilateral seizures – up to 3–4 per month. After additional examination stereotaxic radiofrequency ablation of periventricular heterotopia on the right side was performed in 2019 in the Department of Functional Neurosurgery of the Federal Neurosurgical Center (Novosibirsk). In total 5 ablation spots were made in the periventricular heterotopia. Follow‑up period was 14 months. Right after the operation a transient left‑sided hemiparesis has developed (up to 4 score of MRC scale) which regressed by the time of discharge. During 14 months of the follow‑up period the patient had 3 bilateral tonic‑clonic seizures, however, after 2nd surgical treatment focal seizures did not appear.Conclusion. This clinical case demonstrates sufficient efficacy and relative safety of radiofrequency ablation of periventricular heterotopia in drug‑resistant epilepsy.
A New Decade in Seismoacoustics (2010–2022)
Authors: Dannemann Dugick Fransiska , Koch Clinton , Berg Elizabeth , Arrowsmith Stephen , Albert Sarah 
Published: April 2023

ABSTRACTSeveral sources of interest often generate both low-frequency acoustic and seismic signals due to energy propagation through the atmosphere and the solid Earth. Seismic and acoustic observations are associated with a wide range of sources, including earthquakes, volcanoes, bolides, chemical and nuclear explosions, ocean noise, and others. The fusion of seismic and acoustic observations contributes to a better understanding of the source, both in terms of constraining source location and physics, as well as the seismic to acoustic coupling of energy. In this review, we summarize progress in seismoacoustic data processing, including recent developments in open-source data availability, low-cost seismic and acoustic sensors, and large-scale deployments of collocated sensors from 2010 to 2022. Similarly, we outline the recent advancements in modeling efforts for both source characteristics and propagation dynamics. Finally, we highlight the advantages of fusing multiphenomenological signals, focusing on current and future techniques to improve source detection, localization, and characterization efforts. This review aims to serve as a reference for seismologists, acousticians, and others within the growing field of seismoacoustics and multiphenomenology research.
Comparative study of topical 0.1% tazarotene cream versus calcipotriol 0.005% ointment in the treatment of palmoplantar psoriasis
Authors: Xess Kritika Maria 
Published: April 2023

Palmoplantar psoriasis is classified into two types based on morphology- hyperkeratotic palmoplantar psoriasis and pustular palmoplantar psoriasis. Hyperkeratotic palmoplantar psoriasis presents with well deﬁned erythematous scaly plaques with overlying hyperkeratosis without the presence of sterile pustules, predominantly at the palms and/or soles. There is greater physical and functional disability in patients of palmoplantar psoriasis. Patients with palmoplantar disease are more likely to suffer from a significant impact on skin-related QoL, have problems with activities of daily living, and rely on topical prescription medications than patients with moderate-to-severe plaque psoriasis. These differences are important while creating therapeutic strategies and in understanding patients’ expectations of the treatment. Objective: To compare the clinical efficacy and study the adverse effects of topical 0.1% tazarotene cream and 0.005% calcipotriol ointment in the treatment of palmoplantar psoriasis.A total of 82 palmoplantar psoriasis cases who attended the OPD of a tertiary care hospital in Northern India for a period of two years formed the study group. The study group was randomized into Group A and Group B. Group A participants were instructed to apply a liquid paraffin-based emollient in night, followed by 0.1 % tazarotene cream under occlusion for 12 weeks. Group B patients were instructed to apply calcipotriol ointment 0.005% twice daily on lesions and a liquid-paraffin based emollient in night daily for 12 weeks. The response to treatment was evaluated by improvement in PPPASI at 2-week interval up to 12 weeks.At 12 weeks of follow-up 42.9% patients showed an excellent response, 31.4% showed a clear response in group A. In group B 25% patients had an excellent response and 10% patients showed complete clearance. Adverse effects were seen more in group A.Topical treatment modalities for palmoplantar psoriasis are effective and have a low risk for adverse effects. Both topical calcipotriol 0.005% and tazarotene 0.1% cream are effective in the treatment of palmoplantar psoriasis. While topical tazarotene 0.1% cream showed an excellent clinical response among patients, it was associated commonly with adverse effects such as local irritation and itching in initial weeks of the treatment. Usage of topical 0.005% calcipotriol ointment showed a good clinical response among the patients, with mild side effects of local irritation and itching which resolved on subsequent treatment.
Association of Diabetic Retinopathy with Chronic Kidney Disease Progression in Latinos with Type 2 Diabetes
Authors: Figueroa Ariel E. , Roy Neil , Millan-Ferro Andreina , Silva Paolo S. , Rosas Sylvia E. 
Published: April 2023

AimsDiabetes remains a leading cause of blindness and kidney failure in the United States. Latinos are at increased risk for type 2 diabetes, and microvascular complications such as diabetic retinopathy (DR) and chronic kidney disease (CKD). We evaluated the association of DR with decline in kidney function in Latinos with type 2 diabetes with or without CKD in a multispecialty clinic.MethodsThis is a retrospective cohort study of 351 self-identified Latino individuals with type 2 diabetes enrolled in the Latino Diabetes Initiative at Joslin Diabetes Center. Baseline demographic factors including age, sex, comorbidities, and laboratory values such as A1c and albuminuria were evaluated as predictors of kidney outcomes. The annualized change in estimated glomerular filtration rate (eGFR) was evaluated with a linear regression model. We used logistic regression to evaluate whether DR was associated with development of rapid progressors (&gt;3 mL/min/y eGFR loss) and 30% change in eGFR per year.ResultsDR was present in 39.2% of the cohort with mild nonproliferative DR (NPDR) in 57.1%, moderate to severe NPDR in 27.8%, and proliferative DR in 15.0%. Those with DR had a longer duration of type 2 diabetes (P&lt;.001), higher albuminuria (P=.003), and lower baseline eGFR (P=.001). We found that individuals with moderate to severe NPDR and proliferative DR had a significant decline in GFR (coefficient −6.32; 95% CI, −11.40 to −1.23) and −7.82 (−14.99 to −0.65), compared with individuals without DR.ConclusionsThe presence of DR is a marker for increased eGFR loss, emphasizing the need for routine retinal examinations as part of comprehensive diabetes care. Individuals with DR should be considered at high risk for GFR loss.
RELATIONSHIP BETWEEN ADOLESCENT KNOWLEDGE AND THE ROLE OF PARENTS WITH ADOLESCENT RISKY SEXUAL BEHAVIOR IN BATUROTOK VILLAGE, SUMBAWA REGENCY
Authors: Afilda Munawarah  , Endyka Erye Frety  , Atika  
Published: April 2023

Abstract
BACKGROUND : These days teenagers relationship and dating styles tend to be risky and negative. The results of a preliminary studies showed that several teenagers conveyed their dating pattern, usually holding hands and hugging at school. It was known that not much reproductive health education given to students due to the meager condition of schools and villages. Based on data obtained from the local civil registry office, 30% of the 66 brides who registered marriages in 2020 were a teenagers. Meanwhile, there were data obtained from the Public Health Center showed that 18% by total 28 pregnant women who came for a general check up were a middle and late teens. In addition, the health worker in the village explained that in the last two years there have been several cases of teenagers being exposed to sexually transmitted infections, as well as unwanted pregnancies, some of that case was the result of abused by their parents. The purpose of this research was to analyze the relationship between adolescent knowledge and the role of parents with risky sexual behavior in adolescents in baturotok village, Sumbawa Regency. METHOD : the design of this research is using a cross sectional with a simple random sampling. The ammount of the sample used is this research are 100 respondents. I spread the questionnaire directly accross the students of this school. The independent variables of this research are adolescents knowledge and parents. And the dependent variable of this research is risky sexual behaviour. This research is using Spearman rho statistical correlation analysis in SPSS 21.0 for windows. RESULT : The result of this research indicate that there was a correlation between adolescent knowledge toward a risky sexual behavior(p=0,000, rs=0,681). There was no significant relationship between parents role and risky sexual behavior in Baturotok Village, Sumbawa Regency (p=0,551, rs=-0,060). CONCLUSION : The higher level of adolescent knowledge, would tends the sexual behavior to be low risk and not risky. While the role of parents does not have a significant on the risky sexual behavior of a adolescents in Baturotok village, Sumbawa Regency.
Land Consumption of Current Diets Compared to the Planetary Health Diet: How many People can our Land Feed?
Authors: Schön Anna-Mara , Boehringer Marita 
Published: April 2023

The way people in many countries eat today is disconnected to the resources and land locally available. In Europe, for instance, too much meat is eaten, but often cannot be fed by local resources. The percentage of non-local and non-seasonal food is tremendous, exploiting other regions and their water reservoirs. Current diets harm eco systems and people’s health. (Re-)regionalising food systems and aligning diets to planetary boundaries could be one way to reconnect people to the food they eat. Before demanding the (re-)regionalisation of food, it should be analysed whether current consumption patterns can be met at all with the regionally available agricultural land. We looked at the region Hesse in Central Germany, calculated and compared land consumption of current diets with the consumption as recommended by the Planetary Health Diet. Our focus is on livestock because land consumption to produce meat, dairy and eggs is relatively high. Our results show that the region is far from being able to feed the current livestock population, that it does not have the land to support the livestock needed to meet current consumption patterns, but that it could support a smaller livestock population according to the Planetary Health Diet, especially if farmers adopt crop rotation systems and extensive husbandry.