bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectrophotometric studies of low-cost method for determination of ceftriaxone using a novel charge transfer acceptor, N-(2,4-dinitro-1-naphthyl)-p-toluenesulphonamide
Authors: Umoh O. E. , Adegoke O. A. , Effiong D. E. 
Published: January 2023

AbstractBackgroundThis study reports a new, cost-effective and validated method for the determination of ceftriaxone (CFR). The method involved charge transfer (CT) complexation reaction of ceftriaxone (as n-electron donor) and N-(2,4-dinitro-1-naphthyl)-p-toluenesulphonamide {N-(2,4-DN1NL) PTS} as π-electron acceptor to form a complex. Ultraviolet, infrared and1H NMR spectra of CFR, N-(2,4-DN1NL) PTS and adduct were then studied to predict the site of interaction between the donor and acceptor.ResultThe complex formed had deep golden-yellow colour, having a new absorption band at 440 nm. Molar absorptivity of 1.667 × 105L M−1 cm−1was obtained. The complexation reaction was completed at 30 °C optimal temperature within 10 min. Acetonitrile was found to be the best diluting solvent for optimal detector response and the complex was stable (absorbance unchanged) at room temperature for hours. At concentration of 1.708–11.956 µg mL−1, with low limits of detection of 0.143 µg mL−1, Beer’s law was observed. Between-day recovery statistics of CFR from quality control samples were 102.15 ± 0.062 (% RSD = 0.61, n = 12) over three days. The site of interaction of donor and acceptor molecules, as revealed through infrared (IR) and proton nuclear magnetic resonance studies (1H NMR) and the formation of charge transfer complex is through intermolecular hydrogen bonding between the amino group of the donor and the acidic proton of the acceptor. Common tablet excipients, as observed, did not interfere with the analytical method and no significant difference existed between the results of this new method and the high performance liquid chromatographic procedures (p > 0.05) documented in the USP. The new CT procedure described in this paper is not only simple but also fast, accurate and precise. Also, the reactions were carried out at room temperature compared to previously described procedures.ConclusionsThis novel method could therefore be adopted as a fast but cost-effective alternative for the qualitative and quantitative assessment of CFR in its pure and dosage form. It could find usefulness in on-the-spot detection of counterfeit drugs and in field inspections with reliable accurate results that compares with established methods.
Evaluation of antibacterial, antioxidant, and anti-inflammatory properties of GC/MS characterized methanol leaf extract of Terminalia superba (Combretaceae, Engl. & Diels)
Authors: Ani Njideka Ifeoma , Okolo Kenneth Obinna , Offiah Raymond Ogbonna 
Published: January 2023

Abstract
Background
Terminalia superba is a well-known medicinal plant used in folk medicine for the management of various diseases and swelling. Validation of its efficacy in standardized scientific models is lacking. This gap needs to be filled as a way of enhancing modern drug discovery. The aim is to evaluate the antibacterial, antioxidant, and anti-inflammatory properties of T. superba in known and established models. Also, to establish and possibly correlate the established activity with the phytochemicals identified using GC/MS and qualitative methods.

Results
The result showed a dose-dependent percentage inhibition of DPPH, HO•, and Fe3+ reducing activity. The antibacterial activity showed dose-dependent significant (p < 0.05) inhibition against all the organisms used. The anti-inflammatory activity of METS was confirmed in the carrageenan model with significant (p < 0.05) inhibition of paw volume when compared to control while significantly decreasing (p < 0.05) weight of xylene-induced ear. For instance, after 6 h, there was a reduction of 42%, 33%, and 22% for diclofenac, 200 mg, and 100 mg, respectively, as against 4% in control. The significant (p < 0.05) increase in MDA was attenuated by the treatment with METS dose dependently. Phytochemical assay and GC/MS characterization showed that alkaloids, saponins, phenols, quinone, tannins, coumarins, proteins, flavonoids, and amino acids were dominant with fatty acids accounting for 53%. Others are esters (23%), organic compounds (12%), alkanes (9%), and carboxylic acids (3%).

Conclusions
T. superba possesses antioxidant, antibacterial, and anti-inflammatory properties which are believed to arise from the secondary metabolites observed in the GC–MS characterization.

Graphical Abstract
Effects of physical therapy intervention in the management of neuromyelitis optica: a case report
Authors: Chakraverty Sneha , Dutta Sayak , Das Himadri 
Published: January 2023

Abstract
Background
Neuromyelitis optica is a rare immune-mediated demyelinating central nervous system disorder affecting the spinal cord and optic nerves. There is no permanent cure for this disease, and its management requires a multidisciplinary approach.

Objective
The objective of this case report is to see the effectiveness of physical therapy in the management of neuromyelitis Optica.

Methods
A case of a 13-year-old female with symptoms of left side weakness, balance, and gait impairments administered a 2-week exercise protocol including progressive resistance training for strength improvements, virtual reality gaming for balance and stability improvements, and modified constraint-induced movement therapy for upper extremity functioning and activities of daily living (ADLs). Pre- and post-outcome measures include manual muscle testing (MMT) scores for strength, ProKin TecnoBody assessment for balance and stability, Functional Independence Measure (FIM), and Capabilities of Upper extremity Questionnaire (CUE-Q) for ADLs.

Results
Results showed a marked improvement in the scores of MMT, FIM, CUE, and ProKin TecnoBody post-intervention.

Conclusion
Physical therapy is effective in the management of neuromyelitis optica.
Associations between activity, sedentary and sleep behaviours and psychosocial health in young children: a longitudinal compositional time-use study
Authors: Taylor Rachael W. , Haszard Jillian J. , Meredith-Jones Kim A. , Azeem Anita A. , Galland Barbara C. , Heath Anne-Louise M. , Taylor Barry J. , Healey Dione 
Published: January 2023

Abstract
Background
Good quality sleep, regular physical activity, and limited time spent sedentary are all considered individually important in promoting good mental health in children. However, few studies have examined the influence of each behaviour simultaneously, using compositional analysis which accounts for the closed nature of the 24-h day. Our aim was to determine how compositional time use in early childhood is prospectively related to mental and psychosocial health at 5 years of age.

Methods
A total of 392 children wore Actical accelerometers 24-h a day for one week at 2, 3.5 and 5 years of age to examine time in sleep, physical activity, and sedentary behaviour. Psychosocial and mental health were assessed at age 5 using both laboratory based (researcher-assessed) and questionnaire (parental-report) measures. Associations were estimated using regression models with isometric log-ratios of time-use components as predictors.

Results
Cross-sectionally, 5-year old children who spent 10% (64 min) more time asleep than average had better inhibitory control (standardised mean difference [d]; 0.19; 95% confidence interal [CI]: 0.02, 0.36 for Statue test and d = 0.16; 95% CI: − 0.01, 0.33 for Heads–Toes–Knees–Shoulders task). A greater proportion of time spent active (10%, 31 min) was associated with poorer inhibitory control (d = − 0.07; 95% CI: − 0.13, − 0.02 for Statue test, d = − 0.06; 95% CI: − 0.11, − 0.01 for Heads–Toes–Knees–Shoulders task). By contrast, differences in time-use were not found to be significantly associated with any measure of self-regulation or mental health at 5 years of age, nor were any significant longitudinal relationships apparent.

Conclusions
We did not find a significant association between 24-h time use in the preschool years and any measure of psychosocial or mental health at 5 years of age, although some relationships with inhibitory control were observed cross-sectionally.
Trial registration: ClinicalTrials.gov number NCT00892983, registered 5th May 2009.
The role of mitosis in generating fitness heterogeneity
Authors: Buss Julieti Huch , Lenz Luana Suéling , Pereira Luiza Cherobini , Torgo Daphne , Marcolin Júlia , Begnini Karine Rech , Lenz Guido 
Published: January 2023

ABSTRACT
Cancer cells have heterogeneous fitness, and this heterogeneity stems from genetic and epigenetic sources. Here, we sought to assess the contribution of asymmetric mitosis (AM) and time on the variability of fitness in sister cells. Around one quarter of sisters had differences in fitness, assessed as the intermitotic time (IMT), from 330 to 510 min. Phenotypes related to fitness, such as ERK activity (herein referring to ERK1 and ERK2, also known as MAPK3 and MAPK1, respectively), DNA damage and nuclear morphological phenotypes were also asymmetric at mitosis or turned asymmetric over the course of the cell cycle. The ERK activity of mother cell was found to influence the ERK activity and the IMT of the daughter cells, and cells with ERK asymmetry at mitosis produced more offspring with AMs, suggesting heritability of the AM phenotype for ERK activity. Our findings demonstrate how variabilities in sister cells can be generated, contributing to the phenotype heterogeneities in tumor cells.
ŻYCIE CODZIENNE KAMEDUŁÓW W EREMIE WIGIERSKIM (1667–1800)
Authors: Łupiński Józef 
Published: January 2023

Stosunkowo wiele napisano na temat działalności Kongregacji Kamedułów Pustelników
Góry Koronnej na terenach dawnej Rzeczypospolitej. Najczęściej przedmiotem badań są materialne dokonania zakonu, brakuje natomiast analiz dotyczących sfery duchowej, zachowywania reguły zakonnej, czy też życia codziennego kamedułów. Współczesna historiografia coraz częściej interesuje się codziennością osób konsekrowanych. Léo Moulin – belgijski historyk mediewista zauważył: „świat zakonny jest rozległy, rozmaity, złożony”. Zakony w historii Kościoła katolickiego realizowały własne charyzmaty poprzez modlitwę lub np. działalność na polu miłosierdzia. Zgromadzenie kamedułów zostało założone w Italii w XI wieku. Z czasem zakon stopniowo zmienił swój charakter z eremickiego na cenobicki. Na początku XVI wieku bł. Paweł Giustiniani zainicjował powrót do dawnego radykalnego życia pustelniczego. Centralnym eremem odnowionego zakonu kamedulskiego stała się Góra Koronna (Monte Corona) koło Perugii. Życie codzienne Kongregacji Kamedułów określały Reguły życia eremickiego napisane przez Giustinianiego w 1516 roku, oparte na regułach spisanych przez św. Benedykta oraz św. Romualda2. Celem niniejszego artykułu jest przedstawienie życia codziennego kamedułów w eremie wigierskim działającym w latach 1667–1800, jednym z najbogatszych na ziemiach polskich w oparciu o teksty źródłowe – Reguły i Konstytucje kamedulskie oraz inne dokumenty archiwalne odnoszące się do omawianej wspólnoty eremickiej.
Comparison of Olfactory Thresholds between Elderly with Parkinson Disease and Controls
Authors: Foguem Clovis , Brand Gérard 
Published: January 2023

Introduction: Olfactory dysfunction is an early warning and most common symptom of Parkinson's disease (PD). It is a promising marker mainly at the early stage of the disease for PD. The purpose of the survey was to evaluate the deficits in odor detection in Elderly with PD. We hypothesized that trigeminal sensitivity dysfunction would be less important than olfactory sensitivity impairment in elderly with PD and could improve diagnostic accuracy. Experimental procedure: Olfactory detection thresholds to Phenyl ethyl alcohol (PEA) [activating only the olfactory system] and n- Butanol (BUT) [activating both olfactory and trigeminal systems], were determined in twenty four patients with PD aged over 65 years old [mean age: 75 +/-4.5 years, range: 70-86 years] and in twenty-four healthy controls who were matched for age and gender [mean age: 73 +/-7.1 years, range: 65- 84 years]. The study also included neuropsychological evaluations and stage of PD estimations. Results: Results show a trend towards an impaired olfactory (CN I) detection sensitivity in relation to PEA thresholds in patients with PD compared to controls independently of age and stage of PD, although no significant difference was observed. Furthermore, no significant difference was observed for BUT thresholds between PD’s patients and controls. PEA and BUT thresholds were significantly correlated in both patients with PD and controls. Conclusion: These findings suggest that the olfactory senescence and decreased detection threshold in elderly (both patients with PD and controls) may influence our results by reducing detection olfactory threshold differential between the two groups, contrary to previous findings in young adults with PD and controls. Trigeminal sensitivity seems to be preserved in Elderly with PD. Future investigations should focus on odorants with higher properties to highlight a potential difference between the two groups.
Normative Values and Contralateral Comparison of Anterior Chamber Depth Measured by Orbscan II in an Iranian Population
Authors: Gharaee Hamid , Abrishami Mojtaba , Shafiee Masoud , Zadeh Samira Hasan , Abrishami Mostafa , Eghbali Pardis , Eghbali Parisa 
Published: January 2023

Purpose: The objective of study was (i) to determine the normative values of anterior chamber depth (ACD) with Orbscan II Topography System and (ii) to compare right and left eyes data in the normal young population. Methods: A total of 1001 healthy participants aged 18-45 years participated in this observational cross-sectional study. The study population consisted of 616 female and 385 male subjects. The ACD was measured with the Orbscan II. In our study, ACD was defined as the distance between the corneal epithelium and the anterior lens surface. The differences between genders, between right and left eyes and age-related changes were evaluated. Statistical analyses were performed using student t test. Results: The average ACD in our study population was recorded as 3.653 ± 0.306 mm (median: 3.670 mm, mode: 3.70 mm, minimum: 2.35 mm and maximum: 6.60 mm, 95% Confidence interval: 3.640 to 3.666). The ACD was 3.64±0.30 mm in males and 3.67±0.32 mm in females which was statistically different between genders (P < 0.01). There was a much similarity in ACD values in both eyes. ACD was decreased with age (r= -0.250, p<0.001). Conclusion: Detailed description and analysis of ACD with Orbscan demonstrated that the obtained average value of ACD was higher in female than male and decreased slightly with increasing age. There was no difference between the eyes.
Epidemiologycal Study of Childhood Epilepsy Using the Newly Classification Proposed
Authors: Durá-Travé Teodoro , Yoldi-Petri Maria Eugenia , Aguilera-Albesa Sergio , Gallinas-Victoriano Fidel 
Published: January 2023

Objectives: The aim of this study is to determine the distribution of electroclinical syndromes and other epilepsies in a population-based group of children, using the newly classification proposed by the ILAE. Material & Methods: The study is based on data obtained from the review of the 454 medical records of patients with active epilepsy who were checked in correspondent follow up consultation from January until December 2009. The newly proposed Report of the ILAE Commission on Classification and terminology 2005—2009 has been applied for diagnosis and classification. Results: Most of the clinical entities were electroclinical syndromes (54.8%). In infants, West syndrome and Dravet syndrome were the most prevalent syndromes. In childhood, the main syndromes were benign epilepsy with centrotemporal spikes and childhood absence epilepsy. In adolescents, juvenile absence epilepsy. Epilepsies attributed to and organized by structural-metabolic causes were seen in 20.8% of the patients, with perinatal insults and cerebral malformations as the most prevalent causes. Epilepsies of unknown cause were seen in 24.1% of patients. Conclusions: Using the most recent ILAE classification of epileptic seizures and the epilepsies we were able to identify most cases. The 2005-2009 ILAE classification may serve as the basis for organizing knowledge about recognized forms of epilepsy and facilitate identification of new forms.
Compact non-volatile ferroelectric electrostatic doping optical memory based on the epsilon-near-zero effect
Authors: Zhang Yong , Li Lei , Xie Han , Jiang Zhi , Li Yang , Wang Tongtong , Yao Danyang , Liu Yan , Han Genquan , Hao Yue 
Published: January 2023

With the booming development of optoelectronic hybrid integrated circuits, the footprint and power consumption of photonic devices have become the most constraining factors for development. To solve these problems, this paper proposes a compact, extremely low-energy and non-volatile optical readout memory based on ferroelectric electrostatic doping and the epsilon-near-zero (ENZ) effect. The writing/erasing state of an optical circuit is controlled by electrical pulses and can remain non-volatile. The device works on the principle that residual polarization charges of ferroelectric film, which is compatible with CMOS processes, are utilized to electrostatically dope indium tin oxide to achieve the ENZ state. Simulation results show that a significant modulation depth of 10.4 dB can be achieved for a device length of 60 µm with an energy consumption below 1 pJ.
Freight Fleet Glasses – Augmented Reality Einsatz zur Unterstützung eines automatisierten und vernetzten Flottenmanagements
Authors: Heinbach Christoph , Dreesbach Tobias , Thomas Oliver 
Published: January 2023

ZusammenfassungInnovative Wearable-Technologien haben sich in Form von Smart Glasses (dt.: Datenbrillen) für eine anwender- und prozessorientierte Bereitstellung von Informationen mit einem hohen betrieblichen Nutzen für lagerlogistische Prozesse etabliert. Durch die Verarbeitung von Detailinformationen in Echtzeit sowie die Anbindung an bestehende Informationssysteme, wird der Technologieeinsatz zur Bewältigung komplexer und datengetriebener Arbeitsaufgaben in einem dynamischen Betriebsumfeld auch für das Reparatur- und Instandhaltungsmanagement von Fahrzeugflotten hochrelevant. In Kombination mit einer visuellen Überlagerung von Objekten oder Inhalten in die reale Umgebung durch Augmented Reality (AR) eröffnen sich weitere Potenziale. In diesem Beitrag zeigen die Autoren die Einsatzbereiche von AR für ein automatisiertes und vernetztes Flottenmanagementsystem auf, das im Rahmen eines vom Bundesministerium für Wirtschaft und Klimaschutz geförderten Konsortialforschungsprojekts entsteht. Dazu wird der neuartige Ansatz Freight Fleet Glasses zur kontextadaptiven und automatisierten Ausführung identifizierter Werkstattprozesse präsentiert. Eine Einblendung fahrzeugspezifischer Reparatur- und Instandhaltungsdaten sowie die Dokumentation der Arbeitsprozesse mithilfe einer integrierten Kamera unterstützen die Arbeitsprozesse und den Informationsaustausch des vernetzten Systems. Im Anschluss wird das präsentierte Konzept in das Entwicklungsvorhaben Smart Managed Freight Fleet eingeordnet. Abschließend werden Implikationen für die Akteure im Flottenmanagement im Kontext der digitalen Transformation der Güterverkehrsbranche formuliert. AR-Technologien erhöhen die Prozesseffizienz und können gewinnbringend integriert werden, um nicht ausgeschöpfte Dienstleistungspotenziale für das Flottenmanagement zu heben.
Marktdominanz von Maklern auf Onlineimmobilienportalen in Deutschland und Kalifornien
Authors: Behler Cedric , Gärtner Philip , Linke Hans-Joachim 
Published: January 2023

ZusammenfassungDer Marktanteil von Maklern als wichtige Kenngröße zum Verkaufsprozess auf dem Wohnimmobilienmarkt ist nicht erst seit der Einführung des Bestellerprinzips ein intensiv diskutiertes Thema, zu dem überraschend wenig belastbare Informationen zur Verfügung stehen. Da dieser Missstand des Informationsmangels auch bei vielen weiteren Aspekten von Immobilienmärkten auftritt, ist in jüngerer Vergangenheit verstärkt zu beobachten, dass Daten von Onlineimmobilienportalen, als am weitesten verbreiteter Vermarktungsmöglichkeit, analysiert werden. Diese Studie fügt sich mit einer vergleichenden Analyse der Maklerquote auf dem deutschen sowie dem US-amerikanischen (Teilmarkt Kalifornien) Onlineimmobilienmarkt in diese Bemühungen zur Steigerung der Transparenz ein. Hierzu wurden von marktführenden Immobilienportalen in Deutschland und den USA Angebotsdaten ausgewertet. Die statistische Analyse der insgesamt 69.711 Inserate umfasst dabei sowohl einen aggregierten Vergleich der Maklerquoten zwischen Deutschland und Kalifornien, als auch eine detaillierte Untersuchung über Unterschiede in der Häufigkeit eines Maklereinbezugs zwischen verschiedenen Marktsegmenten mittels einer logistischen Regression. Die zentrale Erkenntnis ist, dass die Maklerquote auf Immobilienportalen mit 98 % in Kalifornien signifikant über der Quote von rund 88 % in Deutschland liegt. Dies bestätigt die anhand der Analyse der Literatur abgeleitete Forschungsfrage, dass sich der Immobilienhandel in den betrachteten Ländern unterscheidet und in Kalifornien dabei häufiger Makler zum Einsatz kommen. Im Detail zeigt sich, dass in beiden Untersuchungsgebieten Eigenschaften wie Objektart und -standard einen Einfluss auf die Chance der Vermarktung mit oder ohne Makler haben. Im Ländervergleich sind dabei teils gleich- und teils gegenlaufende Effekte zu beobachten.
ESR1 gene amplification and MAP3K mutations are selected during adjuvant endocrine therapies in relapsing Hormone Receptor-positive, HER2-negative breast cancer (HR+ HER2- BC)
Authors: Ferrando Lorenzo , Vingiani Andrea , Garuti Anna , Vernieri Claudio , Belfiore Antonino , Agnelli Luca , Dagrada Gianpaolo , Ivanoiu Diana , Bonizzi Giuseppina , Munzone Elisabetta , Lippolis Luana , Dameri Martina , Ravera Francesco , Colleoni Marco , Viale Giuseppe , Magnani Luca , Ballestrero Alberto , Zoppoli Gabriele , Pruneri Giancarlo 
Published: January 2023

Background
Previous studies have provided a comprehensive picture of genomic alterations in primary and metastatic Hormone Receptor (HR)-positive, Human Epidermal growth factor Receptor 2 (HER2)-negative breast cancer (HR+ HER2- BC). However, the evolution of the genomic landscape of HR+ HER2- BC during adjuvant endocrine therapies (ETs) remains poorly investigated.

Methods and findings
We performed a genomic characterization of surgically resected HR+ HER2- BC patients relapsing during or at the completion of adjuvant ET. Using a customized panel, we comprehensively evaluated gene mutations and copy number variation (CNV) in paired primary and metastatic specimens. After retrieval and quality/quantity check of tumor specimens from an original cohort of 204 cases, 74 matched tumor samples were successfully evaluated for DNA mutations and CNV analysis. Along with previously reported genomic alterations, including PIK3CA, TP53, CDH1, GATA3 and ESR1 mutations/deletions, we found that ESR1 gene amplification (confirmed by FISH) and MAP3K mutations were enriched in metastatic lesions as compared to matched primary tumors. These alterations were exclusively found in patients treated with adjuvant aromatase inhibitors or LHRH analogs plus tamoxifen, but not in patients treated with tamoxifen alone. Patients with tumors bearing MAP3K mutations in metastatic lesions had significantly worse distant relapse-free survival (hazard ratio [HR] 3.4, 95% CI 1.52–7.70, p value 0.003) and worse overall survival (HR 5.2, 95% CI 2.10–12.8, p-value < 0.001) independently of other clinically relevant patient- and tumor-related variables.

Conclusions
ESR1 amplification and activating MAP3K mutations are potential drivers of acquired resistance to adjuvant ETs employing estrogen deprivation in HR+ HER2- BC. MAP3K mutations are associated with worse prognosis in patients with metastatic disease.