bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nodal positivity and systemic therapy among patients with clinical T1–T2N0 human epidermal growth factor receptor‐positive breast cancer: Results from two international cohorts
Authors: Weiss Anna , Martínez‐Sáez Olga , Waks Adrienne G. , Laws Alison , McGrath Monica , Tarantino Paolo , Portnow Leah , Winer Eric , Rey María , Tapia Marta , Prat Aleix , Partridge Ann H. , Tolaney Sara M. , Cejalvo Juan M. , Mittendorf Elizabeth A. , King Tari A. 
Published: March 2023

AbstractBackgroundThe optimal treatment strategy for patients with small human epidermal growth factor receptor 2 (HER2)‐positive tumors is based on nodal status. The authors’ objective was to evaluate pathologic nodal disease (pathologic lymph node‐positive [pN‐positive] and pathologic lymph node‐positive after preoperative systemic therapy [ypN‐positive]) rates in patients who had clinical T1–T2 (cT1–cT2)N0M0, HER2‐positive breast cancer treated with upfront surgery or neoadjuvant chemotherapy (NAC).MethodsTwo databases were queried for patients who had cT1–cT2N0M0, HER2‐positive breast cancer: (1) the Dana‐Farber Brigham Cancer Center (DF/BCC) from February 2015 to October 2020 and (2) the Hospital Clinic of Barcelona and the Hospital Clinico of Valencia (HCB/HCV) from January 2012 to September 2021. The pN‐positive/ypN‐positive and axillary lymph node dissection (ALND) rates were compared between patients who underwent upfront surgery versus those who received NAC.ResultsAmong 579 patients from the DF/BCC database, 368 underwent upfront surgery, and 211 received NAC; the rates of nodal positivity were 19.8% and 12.8%, respectively (p = .021). The pN‐positive rates increased by tumor size (p < .001), reaching 25% for those with cT1c tumors. The ypN‐positive rates did not correlate with tumor size. NAC was associated with decreased nodal positivity (odds ratio, 0.411; 95% confidence interval, 0.202–0.838), but the ALND rates were similar (22 of 368 patients [6.0%] who underwent upfront surgery vs. 18 of 211 patients [8.5%] who received NAC; p = .173). Among 292 patients from the HCB/HCV database, 119 underwent upfront surgery, and 173 received NAC; the rates of nodal positivity were 21% and 10.4%, respectively (p = .012). The pN‐positive rates increased with tumor size (p = .011). The ALND rates were equivalent by treatment strategy (23 of 119 patients [19.3%] who underwent upfront surgery vs. 24 of 173 patients [13.9%] who received NAC; p = .213).ConclusionsAmong patients who had cT1–cT2N0M0, HER2‐positive breast cancer, approximately 20% who underwent upfront surgery were pN‐positive, and the rate reached 25% for those with cT1c tumors. Given the opportunity for tailored therapy among lymph node‐positive, HER2‐positive patients, these data provide rationale for future analyses investigating the utility of routine axillary imaging in patients with HER2‐positive breast cancer.
Factors impacting the height of the interproximal papilla: A cross‐sectional study
Authors: Khaireddine Hamdane , Mohamed Tlili , Arij Rmida , Faten Khanfir , Faten Ben Amor 
Published: March 2023

AbstractObjectivesTo determine the relationship between different parameters (age, periodontal phenotype, contact point height, and crown shape) and the height of the interproximal papilla around the teeth of/in the maxillary anterior sector.Material and MethodsA total of 45 subjects were involved in this study, with 315 interproximal papillae of the maxillary anterior sector. The interproximal papillae were clinically classified according to the Norland and Tarnow classification. The periodontal phenotype was assessed by periodontal probe transparency through the marginal gingiva. The height of the papilla, the height of the contact points, and the width/length ratio of the crown were also measured using the periodontal probe. The relationship between the variables was studied using Pearson's correlation. Statistical significance was set at a value of p < .05.ResultsA positive correlation was found between age and the papilla score. However, a negative correlation was noted between age and papilla height, with statistically significant values. A negative correlation was found between the papilla score and the rest of the studied clinical parameters. However, this correlation was not found with regard to the height of the papilla with the same parameters, except for the height of the contact points.ConclusionsA statistically significant relationship was noted between the appearance of the interproximal papillae and all the parameters studied.
Geographic distribution, conservation, and genomic resources of cacao Theobroma cacao L
Authors: Nieves‐Orduña Helmuth E. , Krutovsky Konstantin V. , Gailing Oliver 
Published: March 2023

AbstractThe cacao tree, Theobroma cacao L., is cultivated in the tropics, mainly in agroforestry systems, to produce seeds, the valuable raw material for the chocolate industry. Thus, the conservation and use of cacao genetic resources in breeding programs to increase yield and improve quality and disease resistance are vital for the global cacao economy. We review three important topics of cacao genetics essential for sustainable production and crop improvement: (1) geographic distribution of wild cacao populations and geographic patterns of their genetic variation in Amazonia; (2) conservation, availability, and use of cacao genetic resources in cultivar development; (3) genetic basis of agronomic traits, available molecular genetic markers, and genomic resources and their application for cacao improvement. We also highlight critical research areas needed to achieve sustainable cacao cultivation.
Efficiency optimization for LCC‐LC compensated inductive coupling power transfer system with load‐independent zero‐phase‐angle and constant voltage output
Authors: Ma Hongbo , Pan Yu , Du Juan , Sun Wenzan , Yi Junhong , Li Xiaobin , Xie Meng 
Published: March 2023

SummaryHigh‐order compensation for the inductive coupling power transfer (ICPT) system is preferred due to its high design freedom and excellent coil current harmonics suppression capability. Especially, the good harmonics suppression capability is helpful to implement the synchronous wireless transfer of energy and data with a pair of data communication coils integrated into the energy transfer coils. Thus, on basis of THD1 and THD2 comparison for different high‐order compensation topologies, the LCC‐LC compensated ICPT system with load‐independent zero phase angle (ZPA) and constant voltage output is discussed in this paper. Compared with other high‐order compensation topologies with constant voltage output such as LC‐LC, LC‐LCC, and LCC‐LCC, the LCC‐LC has the advantages of ZPA operation with zero voltage switching and less secondary‐side components. For a given magnetic coupler, infinite feasible combinations of compensation parameters can make the system accomplish ZPA and the same output characteristics. Thus, efficiency optimization of the LCC‐LC compensated ICPT system can be investigated by configuring the optimal compensation parameters. To validate the theoretical analysis, especially the efficiency improvement, the experimental platform with 270 V input and 270 V/3 kW output is designed and built. The comparative experimental results for three different the compensation parameters show the optimized system can improve greatly conversion efficiency over the entire load range, especially under light load.
Rational Biocatalyst Design for a Cyanide‐Free Synthesis of Long‐Chain Fatty Nitriles from Their Aldoximes
Authors: Yavuzer Hilmi , Yang Jianing , Gröger Harald 
Published: March 2023

AbstractRecently, the capability of the aldoxime dehydratase from Bacillus sp. (OxdB) for the transformation of fatty aldoximes into fatty nitriles with impressive substrate loadings is reported. However, the substrate scope of this biocatalyst turned out to be limited in terms of the chain length with decanal oxime being the substrate with the longest well tolerated n‐alkyl chain. Besides the increased bulkiness of the long‐chain aldoximes, their strongly decreased water solubility represents a further hurdle for an efficient biotransformation. Addressing this challenge of an expanded substrate spectrum comprising long‐chain fatty aldoximes, this work investigates the substrate solubility and enzyme kinetics in combination with molecular modeling in order to find an enzyme mutant being suitable for C12‐ to C16‐aldoximes. Both, fatty aldoxime solubility in water and the active site of the wild‐type enzyme OxdB are identified as critical issues for an efficient biotransformation of these substrates. The activity issue is addressed by a rational design of a mutant using a homology modeling as well as a molecular modeling software suitable for enzymes. With the resulting double mutant OxdB‐F289A/L293A, this report can achieve successful biotransformations with the C12‐ to C16‐aldoximes at substrate concentrations of 250 × 10−3 to 1000 × 10−3 m. For example, an excellent conversion of >99% is obtained with tetradecanal oxime.Practical applications: Fatty nitriles with a prolonged chain length of C12 or more are of high interest in industry due to their use for the production of fatty amines on large technical scale. As an alternative route, fatty nitriles can be generated from their aldoximes by means of an aldoxime dehydratase (Oxd) as biocatalyst. The conversion of long‐chain fatty aldoximes, however, remained a challenge up to now. This work describes the optimization of the aldoxime dehydratase OxdB from Bacillus sp. for the dehydration of nonsoluble bulky fatty aldoximes. The created variant can convert long chain fatty aldoximes toward the corresponding nitrile as demonstrated for C12‐ to C16‐nitriles. In addition, high conversion (of up to >99%) is achieved when operating at high substrate concentrations of up to 1000 × 10−3 m, thus making this approach interesting for industrial applications.
Gullies and badlands of India: Genesis, geomorphology and land management
Authors: Majhi Anindya , Harris Angela , Evans Martin , Shuttleworth Emma 
Published: March 2023

AbstractGully erosion is a formidable land degradation process globally. It is omnipresent across India, wherein two of the largest badlands regions in the world also exist. However, despite being affected by widespread gullying, gully erosion research in India has been rather limited, with key aspects of gully formation, morphologies and dynamics remaining unknown. Through this comprehensive systematic review, we synthesise previous studies on gully erosion in India and in turn highlight pivotal knowledge gaps. The review starts with a discussion of the causal factors of gullying in India, which underlines how gully initiation in several regions was an aftermath of deforestation and overgrazing. Contrastingly, the badlands of Central and Western India have mainly developed in response to natural triggers like neotectonics and Holocene climate change. The section on mapping highlights how mapping methodologies have not only been dictated by the availability of imagery and/or means of data processing, but also the mapping purpose—that is, individual gully channels or entire badlands. Although a few studies applying concepts of fractal geometry to characterise badlands’ geomorphology are innovative and unique, the most striking research gaps we have identified also pertain to understanding and quantification of gully geomorphology and erosion dynamics in different regions of India. Our review reveals that gullies of peninsular India have been the least studied, followed by those of the Himalayan and Sub‐Himalayan region. Although the literature provides interesting examples of linkages between badlands development and the wider geomorphic evolution of the landscape, better chronological understanding is required to disentangle the relative importance of natural and anthropogenic drivers of landscape change in India's badlands. Large‐scale mapping of gully characteristics, quantification of gully morphologies, gully erosion rates and its share in catchment sediment budget across various physiographic regions or river basins of the country also constitute important areas for future research.
Late Miocene–early Pliocene tectonic to erosional exhumation in the northwest of the Arabia–Eurasia collision zone
Authors: Madanipour Saeed 
Published: March 2023

AbstractThe exhumation of actively deforming orogenic systems is commonly due to the incision of river systems in response to tectonically driven surface uplift. However, a regional base level and/or climatic variations can also cause erosional exhumation. The temporal and spatial distinction of the dominant mechanism during the topographic evolution of orogens is challenging. Using detailed morphological analyses and thermal modelling of an intrusive body through triple dating (zircon U–Pb, ZHe, and AHe), combined with the previously published structural, detrital, and bedrock low‐temperature thermochronometry (apatite fission track and apatite helium) analysis, the transition from early Oligocene (~27 Ma) and middle Miocene (~12 Ma) tectonic exhumation to late Miocene–early Pliocene (~7–5 Ma) river incision and erosional exhumation in the Talesh Mountains in the NW of the Arabia–Eurasia collision zone was documented. The late Miocene‐early Pliocene incision and the contemporaneous rapid exhumation documented in the Talesh Mountains are related to the base‐level fall of the Caspian Sea due to its isolation from the Paratethys domain. The effect of this base‐level fall then migrated to the margin of the Iranian Plateau and captured the overspilled basins (~4 Ma).
Beam tracking in phased array antenna based on the trajectory classification
Authors: Shirzadian Gilan Mahsa , Paranjape Raman 
Published: March 2023

AbstractOne of the major new concepts in 5G cellular communications is a shift in the way services are delivered to users. In the new 5G protocol, individual users are recognized and tracked through beams, which are targeted and specific to individual users. The millimeter‐wave (mmWave) communications impose a directionality which results in a significant challenge in serving mobile terminals and unmanned aerial vehicles. This challenge can be relieved in mmWave systems using analog beamforming. Based on the identification of the patterns in the reference signal received power (RSRP) measurements, some classifications are employed. Some trajectories are defined for different users in Hallways. Therefore, the angle of arrival (AoA) would be the same for the users following the same trajectory. The users based on the received RSRP values are clustered by K‐means and I‐Kmeans algorithms. To this end, our algorithms to find the beamforming coefficient are employed for only one user in each cluster and the complexity of the algorithms can be lower. The proposed algorithms are spatial frequency‐based beam tracking and angular domain beam tracking algorithms. Simulation results show that tracking the sine function of AoA achieves better performance compared to tracking the AoA. Moreover, the optimal number of clusters is obtained by using the Elbow method.
Preventative and therapeutic potential of animal milk components against COVID‐19: A comprehensive review
Authors: Singh Parminder , Hernandez‐Rauda Roberto , Peña‐Rodas Oscar 
Published: March 2023

AbstractThe global pandemic of COVID‐19 is considered one of the most catastrophic events on earth. During the pandemic, food ingredients may play crucial roles in preventing infectious diseases and sustaining people's general health and well‐being. Animal milk acts as a super food since it has the capacity to minimize the occurrence of viral infections due to inherent antiviral properties of its ingredients. SARS‐CoV‐2 virus infection can be prevented by immune‐enhancing and antiviral properties of caseins, α‐lactalbumin, β‐lactoglobulin, mucin, lactoferrin, lysozyme, lactoperoxidase, oligosaccharides, glycosaminoglycans, and glycerol monolaurate. Some of the milk proteins (i.e., lactoferrin) may work synergistically with antiviral medications (e.g., remdesivir), and enhance the effectiveness of treatment in this disease. Cytokine storm during COVID‐19 can be managed by casein hydrolyzates, lactoferrin, lysozyme, and lactoperoxidase. Thrombus formation can be prevented by casoplatelins as these can inhibit human platelet aggregation. Milk vitamins (i.e., A, D, E, and B complexes) and minerals (i.e., Ca, P, Mg, Zn, and Se) can have significantly positive effects on boosting the immunity and health status of individuals. In addition, certain vitamins and minerals can also act as antioxidants, anti‐inflammatory, and antivirals. Thus, the overall effect of milk might be a result of synergistic antiviral effects and host immunomodulator activities from multiple components. Due to multiple overlapping functions of milk ingredients, they can play vital and synergistic roles in prevention as well as supportive agents during principle therapy of COVID‐19.
The outcome of COVID‐19 patients in the intensive care unit in Sudan: A cross‐sectional study
Authors: Ali Mohammed A. O. , Abdalrahman Noon A. , Shanab Elaf A. I. , Mohammed Mozan M. A. , Ibrahim Malaz M. , Abdalrahman Ihab B. 
Published: March 2023

AbstractBackground and AimA major outbreak of coronavirus spread all over the world and gave rise to high mortality rate and high admission rate to intensive care unit (ICU). This cohort study aims to assess the outcome of COVID‐19 patients in ICU and to investigate the factors associated with mortality.MethodThis is a multicentered retrospective cohort study that was conducted among confirmed cases of COVID‐19 patients, who were admitted to ICU in Sudan during March 2021. The data collection was done manually from the medical records of patients. Mortality rate and association and prediction of factors associated with mortality were obtained using Statistical Package for the Social Sciences software (SPSS) version 22.ResultsThe mortality rate among patients in this study was 70%. Using the chi‐square test we found that age, needing intubation, developing Systemic inflammatory response syndrome, neurological complications, hematological complications, and cardiac complications have a significant association with the outcome.ConclusionMajority of COVID‐19 patients who were admitted to the ICU died. 55.8% of patients developed at least one complication during their stay in ICU. The age, the need for intubation, and developing of systematic inflammatory response syndrome (SIRS) are the factors that predict the mortality.
Sexual and reproductive health teaching in undergraduate medical education: A narrative review
Authors: French Valerie , Steinauer Jody 
Published: March 2023

AbstractObjectiveContraception use, undesired pregnancy, and abortion care are common medical experiences that most physicians will encounter for their patients. Future physicians should therefore have some formal education on these topics. In this narrative review, we focused on how medical education approaches these sometimes polarizing yet fundamental topics.MethodsWe assessed the published literature on sexual and reproductive health education in undergraduate medical education from 2000 to 2021, screening 868 articles and including 52 articles. We included articles that discussed contraception, emergency contraception, pregnancy options counseling, abortion, and ethics related to sexual and reproductive health.ResultsIncluded studies came from 14 countries and described both preclinical and clinical education. Studies assessed medical student knowledge, the effectiveness of educational interventions and medical school faculty perspectives on sexual and reproductive health curricula. Medical educators have employed a variety of approaches to teach sexual and reproductive health including simulation, objective structured clinical examinations, team‐based learning, narrative medicine, online modules, and flipped classrooms.ConclusionStudents generally received sexual and reproductive health education favorably, demonstrating increased knowledge and comfort with these topics after an education session. Studies also identified curricular gaps and deficiencies in student knowledge, which may indicate a need for improved and consistent medical school education on contraception and abortion.
The Year 2022 in biomaterials research: A perspective from the editors of six leading journals
Authors: Stegemann Jan P. , Wagner William R. , Göbel Uta , Perets Ekaterina , Leong Kam W. , Leach J. Kent , Gilbert Jeremy 
Published: March 2023

AbstractThe field of biomaterials science is highly active, with a steadily increasing number of publications and new journals being founded. This article brings together contributions from the editors of six leading journals in the area of biomaterials science and engineering. Each contributor highlights specific advances, topics, and trends that have emerged through the publications in their respective journal in the calendar year 2022. It presents a global perspective on a wide range of material types, functionalities, and applications. The highlighted topics include a diversity of biomaterials; from proteins, polysaccharides, and lipids to ceramics, metals, advanced composites, and a variety of new forms of these materials. Important advances in dynamically functional materials are presented, including a range of fabrication techniques such as bioassembly, 3D bioprinting and microgel formation. Similarly, several applications are highlighted in drug and gene delivery, biological sensing, cell guidance, immunoengineering, electroconductivity, wound healing, infection resistance, tissue engineering, and treatment of cancer. The goal of this paper is to provide the reader with both a broad view of recent biomaterials research, as well as expert commentary on some of the key advances that will shape the future of biomaterials science and engineering.