bluuebunny/crossref_metadata_2025_split huggingface dataset:
Open label randomized controlled trial of a digital therapeutics in temporomandibular disorder (TMD) patients: A preliminary study
Authors: Kim Young-Kyun , Park Sang-Yoon , Kim Daehyun , Kim Bongju , Lee Jong-Ho 
Published: April 2023

Abstract
Background: Temporomandibular disorder (TMD) is a common condition that affects the temporomandibular joint (TMJ) and the muscles of the jaw, resulting in pain and dysfunction. TMD is affected by both behavioral and psychological factors. However, the effectiveness of conservative treatments varies among patients. Digital therapeutics (DTx) is a new treatment approach where a software based medical device is used such as smartphone application. DTx can expect therapeutic effects by controlling behavioral factors through delivery of appropriate intervention and cognitive behavioral therapy. DTx have emerged as a promising alternative treatment option for various chronic conditions, but the development of DTx and the efficacy for TMD have not been fully evaluated.
Objective: The aim of this study is to evaluate the efficacy of a DTx for TMD called ‘Clickless®’, which is the first DTx using a smartphone application for TMD.
Methods: We recruited 40 participants diagnosed with TMD who visited the Bundang Seoul National University Hospital from March to May 2022. Participants were randomly divided into an intervention test group (DTx use) and a control group. The intervention group received the usual treatment process for TMD in addition to the use of the DTx. The control group received the usual treatments only. The patients were followed up in 3-4 weeks for both groups, and the outcome data were collected and analyzed.
Result: The intervention group showed a significant reduction in pain score as measured by the numeral rating scale (NRS) (mean difference 0.82, p = 0.038). Additionally, the intervention test group showed a statistically significant increase in maximal mouth opening compared to the control group. (mean difference 1.38(mm), p = 0.040] However, there was no significant difference of improvement in jaw functional limitation scale, oral behavior checklist, and patient health questionnaire-4 between the two groups.
Conclusion: DTx is an effective treatment option for TMD patients when it applied with the conventional treatments, however further research is necessary to confirm its efficacy and wider application.
Secure Image Transmission through LTE Wireless Communications Systems
Authors: Al-Fahaidy Farouk , Bouthigy Radwan AL , Al-Shamri Mohammad Yahya H. , Abdulkareem Safwan 
Published: April 2023

Abstract
Secure transmission of images over wireless communications systems can be done using RSA, the most known and efficient cryptographic algorithm, and OFDMA, the most preferred signal processing choice in wireless communications. This paper aims to study and investigate the performance of OFDMA system for wireless transmission of RSA-based encrypted images. In fact, the performance of OFDMA systems, based on different signals processing techniques such as, discrete sine transforms (DST) and discrete cosine transforms (DCT), as well as the conventional discrete Fourier transforms (DFT) are tested for wireless transmission of gray scale images with/without RSA encryption. The progress of transmitting the image is carried by firstly, encrypting the image with RSA algorithm, then, the encrypted image is modulated with DFT-based, DCT-based, and DST-based OFDMA systems. After that, the modulated images are transmitted over a wireless multi-path fading channel. The reverse operations will be carried at the receiver, in addition to the frequency domain equalization to overcome the channel effect. Exhaustive numbers of scenarios are performed for study and investigation of the performance of the different OFDMA systems in terms of PSNR and MSE, with different subcarriers mapping and modulation techniques, is done. The obtained results indicate the ability of different OFDMA systems for wireless secure transmission of images. However, the DCT-OFDMA system has shown its superiority over the DST-OFDMA system and the conventional DFT-OFDMA system.
The factors affecting the HRQOL of kidney transplant recipients in the land of Gross National Happiness, Bhutan - A cross-sectional study.
Authors: Dorji Choki , Tobgay Tashi , Na-Bangchang Kesara 
Published: April 2023

Abstract
Purpose
To study the health-related quality of life (HRQOL) of Bhutanese kidney transplant recipients and to examine the relationship between factors affecting the HRQOL.
Methods
An observational study was conducted from January to July 2022. A kidney transplant recipient who underwent surgery until December 2021 and came for therapeutic drug monitoring (TDM) was recruited. Data on HRQOL were collected by face-to-face interviews using a structured questionnaire. A descriptive analysis was used to describe sociodemographic characteristics and HRQOL. Factors affecting HRQOL were analysedusing Mann‒Whitney U and Kruskal‒Wallis tests. Linear regression was used to assess the link between factors and HRQOL.
Results
One hundred kidney transplant recipients were recruited in this study. Of these, 25 of them did not have a formal education, and 48 are employed. 53.0 % of kidney failures were due to hypertension, and 62 of them had dialysis for less than one year. Overall, physical symptoms contributed to poor HRQOL with a mean ± SDscore of 4.9 ± (1.0) and the appearance dimension of better HRQOL at a mean ± SD of 4.0 ± (1.3). Unemployment was significantly associated with poor physical symptoms, uncertainty/fear and emotional dimension. Physical symptoms and age were found to be positive and statistically significant (r = .321, P<0.001).
Factors such as age, hematocrit and BMI are linked with physical symptoms, fatigue and appearance.
Conclusion
Hypertension is the leading cause of kidney failure in Bhutan. The physical symptoms are associated with poor HRQOL among transplant recipients affecting mostly the unemployed. Recipients who are employed and the related donor had a better HRQOL.
Attention to climate change only temporarily diverted by COVID-19
Authors: Repke Tim , Callaghan Max , Lamb William F. , Lück Sarah , Müller-Hansen Finn , Minx Jan C. 
Published: April 2023

Abstract
The COVID-19 pandemic disrupted peoples’ daily lives and dominated the public discourse. It thus displaced people’s attention to and concerns about climate change. We analyze 13.5 million tweets on climate change posted before and after the onset of the pandemic (2018–2021) and show that attention to climate dropped substantially in 2020 with the onset of the pandemic. While research has helped to explain this drop in the context of issue attention theory, our analysis highlights a remarkable recovery in attention in 2021 towards pre-pandemic levels. Moreover, our large-scale, transformer-based text analysis reveals important thematic shifts during this period. In particular, we show a sustained drop in attention to activist movements and subsequently an increased focus on climate causes and climate solutions. This means, that while the climate change discourse in general recovered from the COVID-19 pandemic, activist movements such as the school protests that have mobilized millions around the globe in 2019 have measurably lost traction on Twitter.
Climate Change projections- Impacts and Adaptations on Potato (Solanum tuberosum L.) in West Bengal
Authors: Rana Anchal , Chauhan Nirmla , Dua V K , Chaukhande Paresh 
Published: April 2023

Abstract
Simulation models are useful tools to evaluate the effects of future climatic scenarios on the potential productivity of potato. The present study aimed to evaluate the impact of climate change using WOFOST and InfoCrop for representative concentration pathways (RCPs 4.5 and 6.0) and for future climate scenarios (2030, 2050, and 2080): also to establish the adaptation strategies, either by selecting suitable cultivar or by shifting date of planting or with proper irrigation and nitrogen management practices to compensate yield losses. Potato cultivars belonging to late (Kufri Badshah), medium (Kufri Jyoti), and early (Kufri Pukhraj) maturity cultivars were selected. Based on simulation results, it has been predicted that under RCP 4.5, the cumulative concentration of CO2 is likely to increase, leading to a potential productivity boost of 1.26%, 1.31%, and 1.03% for Kufri Badshah, Kufri Jyoti, and Kufri Pukhraj potato varieties respectively by the year 2030. However, in 2050, a 0.20% and 0.02% increase is expected in Kufri Badshah and Kufri Jyoti, whereas, a decline (0.42%) is projected for Kufri Pukhraj. For 2080, a decline in potential productivity is anticipated for Kufri Badshah (-2.53%), Kufri Jyoti (-2.90%), and Kufri Pukhraj (-3.77%). However, the corresponding increase in temperature is likely to reduce the mean productivity by 5.7, 6.2, and 6.2% in 2030; 10.6, 11.6, and 11.8% in 2050 and 15.9, 17.2, and 17.9% in 2080, for Kufri Badshah, Kufri Jyoti, and Kufri Pukhraj, respectively. However, when the combined influence of temperature and CO2 were considered, these losses can be compensated to some extent for 2030 (1.4, 1.4, and 1.1%), 2050 (0.3, 0.1, and − 0.4%) and 2080 (-2.4, -2.8 and − 3.7%) for Kufri Badshah, Kufri Jyoti, and Kufri Pukhraj, respectively. Alike, for RCP 6.0, elevated concentration of CO2 is likely to increase the mean productivity in 2030 (7.1%), 2050 by 11.6% in, and by 21.1% in 2080. However, the elevated temperature is predicted to decrease the potential productivity in 2030 (-2.7%), 2050 (-6.3%), and 2080 (-17.8%). Although, when the combined effect of temperature and CO2 is considered, the potential productivity of potato is not much affected (4.2% in 2030, 4.6% in 2050, and by 1.0% in 2080). Further, by following adaptation strategies i.e shifting the date of planting and by selecting suitable cultivars productivity can be enhanced. In adaptation, among eleven varieties, Kufri Khyati emerged to be least affected and Kufri Kanchan was affected most by the effect of climate change for future climatic scenarios (2030, 2050, and 2080) for both RCPs (4.5 & 6.0). Further, with proper irrigation and nitrogen management practices, yield can also be increased.
Association between weight control behaviors and health-related quality of life in Korean adults without diabetes: an analysis based on the Korea National Health and Nutrition Examination Survey 2017
Authors: Park Sat Byul 
Published: April 2023

Abstract
Background:Increasing evidence suggests that obesity is associated with a reduction in health-related quality of life (HRQL). HRQL is a widely used measure for assessing the degree of impairment in psychosocial and physical functions associated with disease states. This study aimed to examinethe association between weight control behaviors and HRQL in Korean adults without diabetes.
Methods: This study used data from the 2017 Korea National Health and Nutrition Examination Survey. A total of 3,575 adults without diabetes were selected and divided into four groups according to their weight control behavior: trying to lose weight, trying to maintain weight, trying to gain weight, and not trying to control weight. HRQL was evaluated using the EuroQol five-dimensional (EQ-5D) questionnaire. The EQ-5D consists of five multiple-choice questions and one subjective health level. Health status was determined with respect to the following five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. The participants were asked to choose one of the following three responses: “No problem at all,” “There are some problems,” or “There are many problems.”
Results:A statistically significant difference in the EQ-5D index score was observed among the four groups before and after controlling for age, sex, and body mass index (BMI). ANOVA and Tukey’s post-hoc test showed that the “trying to maintain weight” group had the highest EQ-5D index score. The “trying to lose weight” group had the second highest EQ-5D index score, followed by the “not trying to control weight” group, whereas the “trying to gain weight” group had the lowest EQ-5D index score(p-value compared with the “trying to maintain weight” group = 0.053, 0.001, and 0.002, respectively).
Conclusions: Participants trying to maintain their weight had the best quality of life. Individuals who are interested in their health tend to have a high quality of life. Conversely, individuals who are not interested in their health, such as those who are not trying to control their weight, tend to have a low quality of life. Furthermore, underweight individuals are against health promotion.
A synchronization/desynchronization module for droplet-based microfluidics
Authors: Hakimzadeh Mohammad , Aminizadeh Javad , Moosavi Ali 
Published: April 2023

Abstract
We propose a passive system that can be used to synchronize and desynchronize droplets in parallel microfluidic channels. The proposed system employs a droplet trap and release technique and a valve is also supplied to desynchronize the droplets. The proposed system is not sensitive to the exact time for entering the droplets into the system. The operation of the system was numerically checked.
Transcriptional factor FOXS1 promotes colorectal cancer cell proliferation and invasion in vitro and tumor growth in vivo
Authors: Song Qihi , Tang Yukai , Wu Haijun 
Published: April 2023

Abstract
Colorectal cancer (CRC) has emerged as a major public health concern due to its high incidence and mortality worldwide and a series of transcription factors have been proven by a number of studies to play crucial roles in the development of CRC. In this study, integrative bioinformatics analyses were performed to analyze differentially expressed transcription factors in CRC. FOXS1 was shown to be considerably up-regulated in CRC and linked to patients’ survival according to online data. Furthermore, the expression level of FOXS1 showed to be increased within clinical CRC tissues and cell lines. Concerning cellular functions, FOXS1 knockdown significantly suppressed colony formation and cell invasion of CRC cells; regarding epithelial-mesenchymal transition (EMT) markers, FOXS1 knockdown dramatically elevated E-cadherin proteins but reduced N-cadherin, vimentin, and β-catenin proteins than normal control and sh-NC groups. Conversely, FOXS1 facilitated CRC cell aggressiveness. In the subcutaneous xenograft tumor model, FOXS1 knockdown inhibited, whereas FOXS1 overexpression facilitated tumor growth and EMT. In conclusion, FOXS1 is significantly up-regulated in CRC. Functionally, FOXS1 knockdown repressed the capacity of cancer cells to proliferate and invade in vitro and inhibited tumor growth in the subcutaneous xenograft tumor model in vivo. FOXS1 exerts the oncogenic role in CRC through facilitating the EMT process in CRC.
Epileptogenic Zone with Focal Cortical Dysplasia in the Frontoparietal Lobe: A Voxel-Based Morphometry Analysis
Authors: lin yaoyun , cao xueliang , zhao yang 
Published: April 2023

Abstract
Objective: The abnormal zone of the epileptogenic zone may explain the impact of focal epilepsy on more widespread brain networks involved in typical cognition and development. In some patients, seizures continue after surgery, interfering with accurate detection of potential preoperative zone. This study unraveled zone changes and mechanisms in the frontoparietal cortex of patients with focal cortical dysplasia (FCD) type IIb using voxel-based morphometric analysis before surgery.
Methods: Three-dimensional magnetic resonance images were captured from 22 patients with histologically verified FCD type IIb in the frontoparietal lobe. Twenty-two healthy subjects constituted the control group. Voxel-based morphometry (VBM), xjView, and automated anatomical labeling atlas were used to calculate the volume alteration of the whole-brain gray matter by measuring the increment and decrement of gray matter cluster abnormalities.
Results: A significant increase in gray matter clusters distributed mainly in the bilateral frontal gyrus, temporal gyrus, fusiform, several brain nuclei, and right cerebellum was observed in patients with FCD. Subtle changes were observed in the occipital gyrus, inferior parietal gyrus, paracentral and insular regions in the left hemisphere, hippocampus, parahippocampus, thalamic nuclei, and basal ganglia in the right hemisphere. The VBM results were concordant with the clinical findings.
Conclusions: The VBM analysis established pre-evaluation and surgical strategies. The significant brain regions investigated using VBM potentially improve the prognosis of epilepsy surgeries after complete resection of the epileptogenic zone.
Association between Cerebrospinal fluid pressure and cognition in Alzheimer's disease, Lewy body dimentia
Authors: Yang Xia , Gan Jinghuan , Ji Yong 
Published: April 2023

Abstract
Background: The relationship between cerebrospinal fluid pressure (CSFP) and cognition has received little research attention. The purpose of this study was to explore the relationship between cerebrospinal fluid pressure and cognition in dementia patients with Alzheimer's disease (AD), patients with Lewy body dementia (LBD).
Method: We included 174 participants with dementia, including 131 patients with AD, 36 patients with LBD (including dementia with Lewy bodies (DLB) and parkinson's disease dementia (PDD)). The CSFP was measured by lumbar puncture, and informant-based history, laboratory test and neuroimaging were collected, logistic and linear regression analysis were used to evaluate the associations between CSFP and cognition.
Results: The mean age of the included patients was 63.23±8.9 years and the mean cerebrospinal fluid pressure was 120.89±33.36 mmH2O, 77.0% of patients had a CSFP distribution of [90-170) mmH2O. 39 patients (23.4%) had severe dementia, 78 patients (46.7%) had moderate dementia, and 50 patients (30.0%) had mild dementia. In multivariate analysis, in all participants (OR: 5.81, 95% CI: 1.38-24.37, p = 0.01) and patientswith AD (OR: 6.82, 95%: CI: 1.32-35.18, p = 0.02), the lowest quartile SCFP [50-90) mmH2O was associated with more severe dementia level compared to the highest quartile CSFP [170-210) mmH2O. In addition, there was a significant positive linear correlation between CSFP and MMSE score in all participants (r = 0.42, p ＜ 0.001, Durbin-Watson test = 1.24) and in patientswith AD (r = 0.44, p = 0.006, Durbin-Watson test = 1.20).
Conclusion: In dementia patients with AD, the decrease of CSFP is related to the more serious dementia level, and CSFP have a positive relationship with MMSE score. However, no such relationship was found in patients with LBD.
Exploration of prognostic value and underlying mechanism of P2RY14 in triple negative breast cancer by multi-omics
Authors: Lai Shenglian , Wang Siyan , Ma Ruilan , Li Xingzhe , Mao Min 
Published: April 2023

Abstract
Background Triple negative breast cancer (TNBC) was a highly heterogeneous and invasive breast cancer. Although novel therapeutic strategies had improved, it could not still achieve satisfactory efficacy. P2RY14 participated in the occurrence and development of numerous cancers, while the relationship between P2RY14 and TNBC remained uncertain. Therefore, our aim was to investigate the value of P2RY14 in TNBC to improve this condition.Method The differential expression of P2RY14 was determined based on 158 TNBC and 113 paracancer samples came from TCGA database via Wilcoxon test. The result was validated using GSE37751 and GSE65216 database. Kaplan–Meier analysis was performed to analysis and validate the relationship between P2RY14 and overall survival of TNBC in both TCGA cohort and METABRIC cohort. Patients was divided into low P2RY14 group and high P2RY14 group based the median expression value of P2RY14. Single-sample gene-set enrichment analysis and immune cycle analysis were utilized to investigate underlying mechanism.Result P2RY14 was significant differential expression with P < 0.05 among TCGA, GSE37751 and GSE65216. The methylation of P2RY14 had an inhibitory function in its expression via Pearson correlation analysis (P < 0.05). Patients with high P2RY14 had improved overall survival based on criterion of P < 0.05 in TCGA. The result was validated in METABRIC. Higher immune infiltration in 29 immune cells was mainly closely correlated with high P2RY14 group. Multiple steps of immune cycle were positively associated with High P2RY14 group. In addition, we found that immunotherapy had potential values in high P2RY14 group.Conclusion Our study elucidated the significant value of P2RY14 on pathogenesis and prognosis of TNBC and demonstrated its potential as a novel biomarker. Our results would provide novel perspectives into the prognosis monitoring and decision for TNBC.
The anxiety associated with COVID-19, general health, spiritual health, and job satisfaction in healthcare workers: a cross-sectional study
Authors: Roshani Daem , Saboni Keivan , Amjadian Mohiadin 
Published: April 2023

Abstract
Background: Previous research has shown the impact of pandemic communicable diseases on the mental health of healthcare workers. This study examined the relationship between general health, spiritual health, anxiety associated with COVID-19, job satisfaction, and the mediating role of sex in healthcare workers in Iran in 2021.
Methods: This was a descriptive-analytical and cross-sectional study performed on 163 healthcare workers in some hospitals in Sanandaj. Data were collected using COVID-19 Anxiety, General Health, job satisfaction, and Spiritual Health questionnaires. Then, the data were analyzed using SPSS-22 software, regression test, and path analysis.
Results: Although women averaged lower levels of general health, job satisfaction, anxiety associated with COVID-19, and higher scores in spiritual health than men, none of these differences were statistically significant, and sex didn’t play a significant role here. Also, general health and spiritual health could significantly predict 17.1% of the variance in job satisfaction in the path analysis. However, sex and Covid-19 anxiety could not significantly predict this variable.
Conclusion: The results may help prepare appropriate interventions to reduce the healthcare s’ mental disorders, and to promote general health and job satisfaction during such pandemics.