bluuebunny/crossref_metadata_2025_split huggingface dataset:
A divide-and-conquer control strategy with decentralized control barrier function for luggage trolley transportation by collaborative robots
Authors: Gao Xuheng , Luan Hao , Xia Bingyi , Zhao Ziqi , Wang Jiankun , Meng Max Q.-H. 
Published: August 2023

AbstractThis article focuses on the luggage trolley transportation problem, an essential part of robotic autonomous luggage trolley collection. To efficiently address the nonholonomic constraints derived from the formation of two collaborative robots and a queue of luggage trolleys, we propose a comprehensive framework consisting of a global planning method and a real-time divide-and-conquer control strategy. The popular Hybrid A* algorithm generates a feasible path as the global planner. A model predictive controller is designed to track this path stably and in real time. To maintain the formation so that the whole queue of robots and luggage trolleys does not split, a safety filter that consists of a discrete-time control Lyapunov function and a decentralized control barrier function is implemented in the transportation process. Finally, we conduct real-world experiments to verify the effectiveness of the proposed method on three representative paths, and the results show that our approach can achieve robust performance. The demonstration video can be found at https://www.youtube.com/watch?v=iPiT8BfLIpU.
Electrical Conductivity of Clinochlore Dehydration and Implications for High‐Conductivity Anomalies and the Melting in the Mantle Wedge
Authors: Shen Kewei , Wang Duojun , Wang Libing , Yi Li , Zhang Zhiqing , Cao Chunjie 
Published: August 2023

AbstractThe dehydration of clinochlore may supply water for the creation of high‐conductivity anomalies and melting beneath volcanic arc. However, this process has not yet been constrained even though it is critical to understanding water cycling processes during subduction. The electrical conductivity of clinochlore was measured at pressures of 1.0–4.0 GPa and temperatures of up to 1273 K. The pressure weakly affected the electrical conductivity of clinochlore. In contrast, the electrical conductivity was significantly enhanced when the clinochlore was heated to temperatures beyond 1048 K, which was accompanied by decomposition into spinel, forsterite, enstatite and aqueous fluids. The elevated conductivity associated with the high activation energy may reflect the migration of Mg2+ and Al3+ during dehydration. We suggested that the aqueous fluids were released from both talc‐like and brucite‐like layer in the clinochlore, and the volumes of fluids released by samples post mortem determined using X‐ray computed tomography were 7.9–11.5 vol.%. Our results indicate that the dehydration of clinochlore results in a significant increase in conductivity of up to ∼1 S/m due to the interconnected network formed by the fluids. Combined with the geothermal gradient, the experimental data were used to interpret the high‐conductivity anomalies observed at depths of 75–120 km in hot subduction zones and 150–200 km in cold subduction zones. The updip migration of aqueous liquids liberated by clinochlore may act as a major water source for the melting at depths of 110 ± 20 km above the descending slab beneath a volcanic arc.
Hillslope‐Channel Transitions and the Role of Water Tracks in a Changing Permafrost Landscape
Authors: Del Vecchio Joanmarie , Zwieback Simon , Rowland Joel C. , DiBiase Roman A. , Palucis Marisa C. 
Published: August 2023

AbstractThe Arctic is experiencing rapid climate change, and the effect on hydrologic processes and resulting geomorphic changes to hillslopes and channels is unclear because we lack quantitative models and theory for rapid changes resulting from thawing permafrost. The presence of permafrost modulates water flow and the stability of soil‐mantled slopes, implying that there should be a signature of permafrost processes, including warming‐driven disturbance, in channel network extent. To inform understanding of hillslope‐channel dynamics under changing climates, we examined soil‐mantled hillslopes within a ∼300 km2 area of the Seward Peninsula, western Alaska, where discontinuous permafrost is particularly susceptible to thaw and rapid landscape change. In this study, we pair high‐resolution topographic and satellite data to multi‐annual observations of InSAR‐derived surface displacement over a 5‐year period to quantify spatial variations in topographic change across an upland landscape. We find that neither the basin slope nor the presence of knickzones controls the magnitude of recent surface displacements within the study basin, as may be expected under conceptual models of temperate hillslope evolution. Rather, the highest displacement magnitudes tended to occur at the broad hillslope‐channel transition zone. In this study area, this zone is occupied by water tracks, which are zero‐order ecogeomorphic features that concentrate surface and subsurface flow paths. Our results suggest that water tracks, which appear to occupy hillslope positions between saturation and incision thresholds, are vulnerable to warming‐induced subsidence and incision. We hypothesize that gullying within water tracks will outpace infilling by hillslope processes, resulting in the growth of the channel network under future warming.
C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption
Authors: Sharma Abhishek Bharadwaj , Ramlee Muhammad Khairul , Kosmin Joel , Higgs Martin R. , Wolstenholme Amy , Ronson George E. , Jones Dylan , Ebner Daniel , Shamkhi Noor , Sims David , Wijnhoven Paul W. G. , Forment Josep V. , Gibbs-Seymour Ian , Lakin Nicholas D. 
Published: August 2023

AbstractWhile the toxicity of PARP inhibitors to cells with defects in homologous recombination (HR) is well established, other synthetic lethal interactions with PARP1/PARP2 disruption are poorly defined. To inform on these mechanisms we conducted a genome-wide screen for genes that are synthetic lethal with PARP1/2 gene disruption and identified C16orf72/HAPSTR1/TAPR1 as a novel modulator of replication-associated R-loops. C16orf72 is critical to facilitate replication fork restart, suppress DNA damage and maintain genome stability in response to replication stress. Importantly, C16orf72 and PARP1/2 function in parallel pathways to suppress DNA:RNA hybrids that accumulate at stalled replication forks. Mechanistically, this is achieved through an interaction of C16orf72 with BRCA1 and the RNA/DNA helicase Senataxin to facilitate their recruitment to RNA:DNA hybrids and confer resistance to PARP inhibitors. Together, this identifies a C16orf72/Senataxin/BRCA1-dependent pathway to suppress replication-associated R-loop accumulation, maintain genome stability and confer resistance to PARP inhibitors.
Reduced body cell mass and functions in lower extremities are associated with mild cognitive impairment and Alzheimer’s dementia
Authors: Doan Dieu Ni Thi , Kim Kahye , Ku Boncho , Lee Kun Ho , Kim Jaeuk U. 
Published: August 2023

AbstractThis study examined the alterations of segmental body composition in individuals with Alzheimer’s pathology (AD), including mild cognitive impairment (MCI) and dementia. A multifrequency bioimpedance analysis (BIA) was used to provide segmental water and impedance variables from 365 cognitively normal (CN), 123 MCI due to AD, and 30 AD dementia participants. We compared the BIA variables between the three groups, examined their correlations with neuropsychological screening test scores, and illustrate their 95% confidence RXc graphs. AD dementia participants were older, more depressive, and had worse cognitive abilities than MCI due to AD and CN participants. Although the BIA variables showed weak partial correlations with the cognitive test scores, we found patterns of an increasing water content in lean mass, increasing extra to intracellular water ratio, and decreasing reactance and phase angle in the lower extremities with effect sizes ranging from 0.26 to 0.51 in the groups of MCI and dementia due to AD compared with CN individuals. The RXc graphs upheld the findings with a significant displacement downward and toward the right, dominantly in the lower extremities. Individuals with AD pathology exhibit a reduced body cell mass or cell strength, an abnormal cellular water distribution, and an overhydration status in lean mass, especially in the lower extremities.
Mediation effect of emotional self-regulation in the relationship between physical activity and subjective well-being in Chilean adolescents
Authors: Fuentealba-Urra Sergio , Rubio Andrés , González-Carrasco Mònica , Oyanedel Juan Carlos , Céspedes-Carreno Cristian 
Published: August 2023

AbstractAdolescents' subjective well-being and physical activity have been found to be correlated in previous studies. However, the underlying mechanisms of this relationship, especially the potential contribution of emotional self-regulation, have received little attention. This study aims to investigate the extent to which emotional self-regulation mediates the association between adolescent physical activity habits and their subjective well-being. The study involved 9585 adolescents who completed a cross-sectional survey. Participants were aged between 10 and 19 years old and attended primary and secondary schools in all 16 regions of Chile. The survey utilized a self-report questionnaire to measure physical activity habits, subjective well-being, and emotional self-regulation. Sociodemographic variables, such as age, gender, and socioeconomic level, were also considered in the analysis. The results showed that physical activity habits, emotional regulation, and subjective well-being were positively correlated. Among these factors, the strongest association was found between subjective well-being and emotional self-regulation. The mediation analysis revealed a partial mediation effect of emotional self-regulation between physical activity habits and subjective well-being. In other words, physical activity habits affect subjective well-being to the extent that these habits affect emotional self-regulation. These findings provide valuable insights into the mechanisms underlying the link between physical activity habits and subjective well-being among adolescents. They also offer useful information for the development of public programs and policies aimed at promoting physical activity habits and subjective well-being in young people.
Influence of the asthenosphere on earth dynamics and evolution
Authors: Cathles Lawrence , Fjeldskar Willy , Lenardic Adrian , Romanowicz Barbara , Seales Johnny , Richards Mark 
Published: August 2023

AbstractThe existence of a thin, weak asthenospheric layer beneath Earth’s lithospheric plates is consistent with existing geological and geophysical constraints, including Pleistocene glacio-isostatic adjustment, modeling of gravity anomalies, studies of seismic anisotropy, and post-seismic rebound. Mantle convection models suggest that a pronounced weak zone beneath the upper thermal boundary layer (lithosphere) may be essential to the plate tectonic style of convection found on Earth. The asthenosphere is likely related to partial melting and the presence of water in the sub-lithospheric mantle, further implying that the long-term evolution of the Earth may be controlled by thermal regulation and volatile recycling that maintain a geotherm that approaches the wet mantle solidus at asthenospheric depths.
Aptamer-based assay for rapid detection, surveillance, and screening of pathogenic Leptospira in water samples
Authors: Vishwakarma Archana , Meganathan Yogesan , Ramya Mohandass 
Published: August 2023

AbstractLeptospirosis is a potentially fatal waterborne infection caused by Leptospira interrogans, impacting both humans and animals in tropical regions. However, current diagnostic methods for detecting pathogenic Leptospira have sensitivity, cost, and time limitations. Therefore, there is a critical need for a rapid, sensitive, and cost-effective detection method. This study presents the development of an aptamer-based assay for pathogenic Leptospira detection. Aptamers targeting Leptospira were generated using the SELEX method and screened for binding affinity with major Leptospiral outer membrane proteins through in silico analysis. The aptamer with the highest binding affinity was selected for further evaluation. To enable visual detection, the aptamer was conjugated to gold nanoparticles (AuNPs), resulting in a colorimetric response in the presence of L. interrogans. The aptamer-AuNP-based colorimetric assay exhibited a detection limit of 57 CFU/mL and demonstrated high specificity and reproducibility in detecting pathogenic Leptospira in water samples. This aptamer-based assay represents a significant advancement in leptospirosis diagnostics, offering a rapid, sensitive, and cost-effective approach for detecting pathogenic Leptospira. Its potential for epidemiological applications, such as outbreak source identification and improved prevention, diagnosis, and treatment, particularly in resource-limited settings, highlights its importance in addressing the challenges associated with leptospirosis.
Developing multitarget coumarin based anti-breast cancer agents: synthesis and molecular modeling study
Authors: Takla Fiby N. , Bayoumi Waleed A. , El-Messery Shahenda M. , Nasr Magda N. A. 
Published: August 2023

AbstractA new series of 7-substituted coumarin scaffolds containing a methyl ester moiety at the C4-position were synthesized and tested for their in vitro anti-proliferative activity against MCF-7 and MDA-MB-231 breast cancer cell lines using Doxorubicin (DOX) as reference. Compounds 2 and 8 showed noticeable selectivity against MCF-7 with IC50 = 6.0 and 5.8 µM, respectively compared to DOX with IC50 = 5.6 µM. Compounds 10, 12, and 14 exhibited considerable selectivity against Estrogen Negative cells with IC50 = 2.3, 3.5, and 1.9 µM, respectively) compared to DOX with (IC50 = 7.3 µM). The most promising compounds were tested as epidermal growth factor receptor and aromatase (ARO) enzymes inhibitors using erlotinib and exemestane (EXM) as standards, respectively. Results proved that compound 8 elicited the highest inhibitory activity (94.73% of the potency of EXM), while compounds 10 and 12 displayed 97.67% and 81.92% of the potency of Erlotinib, respectively. Further investigation showed that the promising candidates 8, 10, and 12 caused cell cycle arrest at G0–G1 and S phases and induced apoptosis. The mechanistic pathway was confirmed by elevating caspases-9 and Bax/Bcl-2 ratio. A set of in silico methods was also performed including docking, bioavailability ADMET screening and QSAR study
The role of sense of presence in expressing cognitive abilities in a virtual reality task: an initial validation study
Authors: Palombi Tommaso , Galli Federica , Giancamilli Francesco , D’Amico Monica , Alivernini Fabio , Gallo Luigi , Neroni Pietro , Predazzi Marco , De Pietro Giuseppe , Lucidi Fabio , Giordano Antonio , Chirico Andrea 
Published: August 2023

AbstractThere is a raised interest in literature to use Virtual Reality (VR) technology as an assessment tool for cognitive domains. One of the essential advantages of transforming tests in an immersive virtual environment is the possibility of automatically calculating the test’s score, a time-consuming process under natural conditions. Although the characteristics of VR can deliver different degrees of immersion in a virtual environment, the sense of presence could jeopardize the evolution of these practices. The sense of presence results from a complex interaction between human, contextual factors, and the VR environment. The present study has two aims: firstly, it contributes to the validation of a virtual version of the naturalistic action test (i.e., virtual reality action test); second, it aims to evaluate the role of sense of presence as a critical booster of the expression of cognitive abilities during virtual reality tasks. The study relies on healthy adults tested in virtual and real conditions in a cross-over research design. The study’s results support the validity of the virtual reality action test. Furthermore, two structural equation models are tested to comprehend the role of sense of presence as a moderator in the relationship between cognitive abilities and virtual task performance.
Computational modeling and minimization of unintended neuronal excitation in a LIFU stimulation
Authors: Fan Boqiang , Goodman Wayne , Cho Raymond Y. , Sheth Sameer A. , Bouchard Richard R. , Aazhang Behnaam 
Published: August 2023

AbstractThe neuromodulation effect of low-intensity focused ultrasound (LIFU) is highly target-specific. Unintended off-target neuronal excitation can be elicited when the beam focusing accuracy and resolution are limited, whereas the resulted side effect has not been evaluated quantitatively. There is also a lack of methods addressing the minimization of such side effects. Therefore, this work introduces a computational model of unintended neuronal excitation during LIFU neuromodulation, which evaluates the off-target activation area (OTAA) by integrating an ultrasound field model with the neuronal spiking model. In addition, a phased array beam focusing scheme called constrained optimal resolution beamforming (CORB) is proposed to minimize the off-target neuronal excitation area while ensuring effective stimulation in the target brain region. A lower bound of the OTAA is analytically approximated in a simplified homogeneous medium, which could guide the selection of transducer parameters such as aperture size and operating frequency. Simulations in a human head model using three transducer setups show that CORB markedly reduces the OTAA compared with two benchmark beam focusing methods. The high neuromodulation resolution demonstrates the capability of LIFU to effectively limit the side effects during neuromodulation, allowing future clinical applications such as treatment of neuropsychiatric disorders.
Experimental solubility of aripiprazole in supercritical carbon dioxide and modeling
Authors: Ansari Eslam , Honarvar Bizhan , Sajadian Seyed Ali , Aboosadi Zahra Arab , Azizi Mehdi 
Published: August 2023

AbstractThe solubility of compounds in supercritical carbon dioxide (SC-$${\mathrm{CO}}_{2}$$

CO
2

) has found crucial significance in the fabrication of micro/nano-scaled drugs. In this research, the solubility of Aripiprazole was measured in SC-$${\mathrm{CO}}_{2}$$

CO
2

at various temperatures (308–338 K) and pressures (12–30 MPa). Moreover, the experimental solubility results were correlated with several semi-empirical models (Chrastil, Bartle et al., Kumar & Johnston, Menden-Santiago & Teja, Sodeifian et al., and Jouyban et al.) as well as the modified Wilson model. The molar fraction of the drug in SC-$${\mathrm{CO}}_{2}$$

CO
2

varied in the range of $$1.830\times {10}^{-6}$$

1.830
×

10

-
6

to $$1.036\times {10}^{-5}$$

1.036
×

10

-
5

. The solubility highly depended on the operating pressure and temperature. The Chrastil (0.994), Jouyban et al. (0.993) and Sodeifian et al. (0.992) models showed the highest consistency with the obtained values. Furthermore, self-consistency tests were performed on the solubility of Aripiprazole in SC-$${\mathrm{CO}}_{2}$$

CO
2

. The approximate total enthalpy ($${\mathrm{\Delta H}}_{\mathrm{total}}$$

Δ
H

total

), vaporization enthalpy ($${\mathrm{\Delta H}}_{\mathrm{vap}}$$

Δ
H

vap

), and solubility enthalpy ($${\mathrm{\Delta H}}_{\mathrm{sol}}$$

Δ
H

sol

) were also calculated.
Spatio-temporal process and influencing factors of polluting enterprises' migration: an empirical study based on the Yangtze River Delta
Authors: Lin Bingquan 
Published: August 2023

AbstractThe migration of polluting enterprises (MPE) is a crucial subject within the fields of Environmental Economic Geography and Enterprise Geography. An analysis was conducted on the temporal-spatial evolution and influencing factors of the MPE by employing the full-sample enterprises data from the "Qichacha" system. The main findings were obtained: (1) The polluting enterprises in the Yangtze River Delta have undergone an evolutionary process of proximity migration, intra-provincial proximity to intra-provincial long distance migration, with intra-provincial migration being the main focus supplemented by inter-provincial migration, and coexisting intra-provincial and inter-provincial migration. (2) The estimation results, based on the panel negative-binomial model, reveal that the variables having a greater impact on the MPE encompass environmental regulation, industrial upgrading policies, cost factors, geographical distance, coastal and inter-provincial boundaries, etc. These influencing factors display time heterogeneity and industry heterogeneity. (3) By taking the Nijiaxiang Group, which was involved in the 321 Explosion Accident in Xiangshui, as an example, it was discovered that insufficient inheritance of environmental protection concepts, corruption of officials, and social governance problems have resulted in shortcomings in the area. This has led to a lowered level of local environmental regulation, transforming the local area into a haven for polluting enterprises such as the Nijiaxiang Group. The contribution of this study lies in observing the MPE from the perspective of "inter-regional association," and within the group enterprises. It addresses the deficiencies of existing research that mainly examines the evolution of industrial geographic patterns and statically observes polluting enterprises' entry and exit behavior. Moreover, this study demonstrates that the Pollution Shelter Hypothesis is not universal and has an impact in the Yangtze River Delta region after 2012.
The identification of genes associated T-cell exhaustion and construction of prognostic signature to predict immunotherapy response in lung adenocarcinoma
Authors: Wu Yahua , Du Bin , Lin Mingqiang , Ji Xiaohui , Lv Chengliu , Lai Jinhuo 
Published: August 2023

AbstractT-cell exhaustion (Tex) is considered to be a reason for immunotherapy resistance and poor prognosis in lung adenocarcinoma. Therefore, we used weighted correlation network analysis to identify Tex-related genes in the cancer genome atlas (TCGA). Unsupervised clustering approach based on Tex-related genes divided patients into cluster 1 and cluster 2. Then, we utilized random forest and the least absolute shrinkage and selection operator to identify nine key genes to construct a riskscore. Patients were classified as low or high-risk groups. The multivariate cox analysis showed the riskscore was an independent prognostic factor in TCGA and GSE72094 cohorts. Moreover, patients in cluster 2 with high riskscore had the worst prognosis. The immune response prediction analysis showed the low-risk group had higher immune, stromal, estimate scores, higher immunophenscore (IPS), and lower tumor immune dysfunction and exclusion score which suggested a better response to immune checkpoint inhibitors (ICIs) therapy in the low-risk group. In the meantime, we included two independent immunotherapy cohorts that also confirmed a better response to ICIs treatment in the low-risk group. Besides, we discovered differences in chemotherapy and targeted drug sensitivity between two groups. Finally, a nomogram was built to facilitate clinical decision making.
Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice
Authors: Liu Dongmin , Wang Siyu , Liu Yaqing , Luo Yong , Wen Beibei , Wu Wenliang , Zeng Hongliang , Huang Jianan , Liu Zhonghua 
Published: August 2023

High-fat diet (HFD) induced hepatic steatosis and steatohepatitis were ameliorated by Fuzhuan brick tea (FBT) via AhR-ligand producing microbiota and their tryptophan metabolism.