bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in Area of Occurrence and Biomass of Fish and Macroinvertebrates on the Northeast U.S. Shelf Ecosystem
Authors: Friedland Kevin D. , Tanaka Kisei R. , Smoliński Szymon , Wang Yanjun , Hodgdon Cameron , Mazur Mackenzie , Wiedenmann John , Goetsch Chandra , Pendleton Daniel E. 
Published: April 2023

Abstract
Climate change can affect the habitat of marine species and hence their persistence and adaptation. Trends in area of occurrence and population biomass were examined for 177 fish and macroinvertebrates resident to the Northeast U.S. Continental Shelf ecosystem. Samples of these organisms were taken during a time series of research bottom trawl surveys conducted in the spring and autumn 1976–2019. The occurrence area of each taxon was modeled as the distribution of occurrence probability based on a random forest presence/absence classification model. Following, a population biomass of each taxon was modeled as a minimum swept area estimate, where the ecosystem was stratified biannually based on each taxon's spatial distribution. In both seasons, the sum of occurrence area and biomass across all modeled species increased over the study period. The summation of biomass is problematic since catchability is not known for most species; more importantly, most time series of individual species biomass trended higher. We found that the ratio of biomass to occurrence area, intended as a measure of productivity, showed no change in the autumn and had a weak increasing trend in spring. For the majority of taxa, the rate of change in biomass tracked changes in occurrence area (either positive or negative), but there were cases where the direction of change in biomass was opposite to the direction of change in occurrence area. Thermal conditions in surface waters appear to be a more important driver of occurrence area and biomass change than the change in thermal conditions near the bottom. These findings provide critical insights into the expected changes in ecosystem productivity transpiring with climate change.
Dual‐band Ganesha‐shaped semi‐transparent antenna for vehicular applications
Authors: Borah Pranjal 
Published: April 2023

AbstractIn this paper, work on a Ganesha‐shaped semi‐transparent patch antenna is presented for its use in vehicular application. The design of the antenna is opted from a commercially available Ganesha sticker that is mostly placed on the vehicle's window panes as a symbol of an auspicious deity. The geometry of the sticker without any variation in its dimension is made to work as an antenna. The antenna is fabricated using adhesive copper tape on a glass slab backed by an AgHT‐8 transparent conducting sheet which acts as the ground plane. Microstrip inset feeding technique is used to excite the patch and its return loss performance and free space radiation pattern measurements are carried out. Measured results show promising performances that can be used in future vehicular applications and are in good comparison with that of the simulated results.
Experiences and challenges of the use Subacute and Acute Dysfunction in the Elderly‐SAFE Work team coordinators experiences and challenges in the introduction and use of SAFE in home‐based nursing: A qualitative study from the Norwegian context
Authors: Abudayya Abdallah , Hamre Annabel , Pajalic Zada , Knudsen Cervino Hanne , Wesseltoft‐Rao Nima 
Published: April 2023

AbstractOld age is the leading cause of impaired bodily function, which gradually increases healthcare service needs. To offer the best possible care in the home and to be able to detect health‐related functional impairment at an early stage, it is necessary to carry out systematic and structured observations. The assessment tool Subacute and Acute Dysfunction in the Elderly (SAFE) has been developed explicitly for these structured observations. This study aims to explore the experiences and challenges of home‐based care work team coordinators (WTCs) regarding the introduction and use of SAFE.MethodThe present qualitative study was performed following Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines. The data were collected through individual interviews (n = 3) and focus group (FG) interviews (n = 7). The interview transcripts were analysed using the Gioia method.ResultsFive aggregated dimensions were identified: Varying acceptance of SAFE, Structuring and quality‐assurance of home‐based nursing practice, Obstacles for the integration of SAFE in daily practice, Acceptance and use of SAFE require continuous supervision and SAFE contributes to increased quality of nursing care.ConclusionThe introduction of SAFE contributes to a structured follow‐up of functional status in patients receiving home care. In order to incorporate the tool into home care practice, it is essential to set aside time to introduce the tool and to support nurses' use of it by offering continuous supervision.
Factors associated with different patterns of weight change after bariatric surgery: A longitudinal study
Authors: Henao Carrillo Diana Cristina , Gómez Ana María , Muñoz Oscar M. , Rubio Claudia , Rodríguez Natalia , Ursida Valentina , Forero Ana Milena , Pinzón Fabio , Mikler Rami 
Published: April 2023

AbstractBackgroundThe mean weight loss (WL) after successful bariatric surgery is approximately one third of the initial body weight, which is mainly achieved between the first 2 years of follow‐up. However, 15%–35% of patients do not achieve a significant percentage of total WL (%TWL). Information on factors associated with a higher or lower WL after bariatric surgery is limited. This study aimed to assess the change in %TWL and describe the factors associated with greater or lesser WL over time.MethodsThis prospective longitudinal study included patients treated with laparoscopic Roux‐en‐Y gastric bypass or sleeve gastrectomy. Baseline data were recorded before surgery. Follow‐up was performed at 3 (n = 141), 6 (n = 208), 9 (n = 115), 12 (n = 216), 24 (n = 166), and 36 months (n = 99). Generalized estimating equation analysis was performed to assess the changes in %TWL over time and factors associated with different patterns of WL.ResultsIn total, 231 patients were included (women, 82.2%; basal body mass index (BMI) 41.4 ± 5.1 kg/m2). The tendencies to increase %TWL (32 ± 6.5) were evident in the first year and stabilized thereafter. Sustained nutritionist follow‐up (2.3%, p = 0.004), baseline BMI >40 kg/m2 (0.4%, p < 0.001), and WL ≥ 10 kg before surgery (0.3%, p = 0.001) were associated with a higher %TWL. Patients who performed physical activity >30 min/day after surgery reduced their %TWL by 0.6% (p = 0.002).ConclusionsModifiable factors such as nutritional monitoring and WL before surgery are associated with a significant increase in %TWL over time. Basal BMI was associated with a significant decrease in %TWL.
Safety and efficacy of multiple tyrosine kinase inhibitors in pediatric/adolescent and young adult patients with relapsed or refractory osteosarcomas: A single‐institution retrospective analysis
Authors: Sugiyama Masanaka , Arakawa Ayumu , Shirakawa Nami , Tao Kayoko , Tanimura Kazuki , Nakajima Miho , Watanabe Yuko , Kumamoto Tadashi , Maniwa Junnosuke , Yoneda Akihiro , Iwata Shintaro , Kobayashi Eisuke , Kawai Akira , Ogawa Chitose 
Published: April 2023

AbstractBackgroundThe prognosis of relapsed or refractory osteosarcoma remains poor. Recent reports have stated that molecular targeting agents, including multiple tyrosine kinase inhibitors (MTKIs), are effective against adult osteosarcoma. To determine the safety and efficacy of MTKI therapy in children, adolescents and young adults (AYAs), we conducted a retrospective study on adverse events and treatment outcomes.MethodsWe retrospectively reviewed the medical records of patients with relapsed or refractory osteosarcoma who received MTKI therapy at the Department of Pediatric Oncology, National Cancer Center Hospital, from December 2013 to May 2021.ResultsThe study included 31 patients (15 males and 16 females) who received MTKIs, including sorafenib monotherapy (seven patients), sorafenib and everolimus (14 patients), and regorafenib monotherapy (10 patients). Their median age was 17 years (range: 11–22 years). The incidence of treatment‐related grade 3 nonhematological adverse events was 14.3% in the sorafenib monotherapy group, 21.4% in the sorafenib with everolimus group, and 20.0% in the regorafenib monotherapy group. No grade 4 nonhematological adverse events were observed. The median progression‐free survival (PFS) was 51 days in the sorafenib monotherapy group, 101 days in the sorafenib with everolimus group, and 167 days in the regorafenib monotherapy group.ConclusionThe safety profile of MTKI therapies in pediatric and AYA patients was comparable to that in adult patients. MTKI therapies, particularly regorafenib, against pediatric relapsed osteosarcoma can suppress tumor growth and prolong PFS with tolerable adverse events.
ANNbased prediction of the absorption characteristics of additive manufactured glycol‐modified polyethylene terephthalate nanocomposites reinforced with short‐carbon fibers and nanoclay fillers
Authors: Mahesh Vinyas 
Published: April 2023

AbstractIn this research work, an artificial neural network (ANN) based data driven prediction technique is proposed to evaluate the absorption characteristics of glycol‐modified polyethylene terephthalate (PETG) polymer nanocomposites reinforced with short carbon fibers (SCFs) and organically modified montmorillonite (OMMT) nanoclay (NC) fillers. The specimens are fabricated through additive manufacturing routine. The data points owing to the absorption of PETG nanocomposites are collected with the aid of the experimentation, which are then used to train the ANN model using Levenberg–Marquardt backward propagation algorithm. Different variants of PETG nanocomposites are prepared using various weight percentages of NC (1%, 3%, and 5%) and SCFs (5%, 10%, and 15%). The required filaments were prepared with the aid of compounding and extrusion processes. The specimens were printed using the fused deposition modeling technique. Further, the absorption behavior of these nanocomposites when exposed to distilled water, salt solution, and sugar solution has been experimentally studied following the ASTM D570 standard. The individual and combined effects of reinforcing OMMT‐NC and SCFs in the PETG matrix are also studied. The experimental results suggest that the absorption characteristics of PETG nanocomposites are significantly affected by the NC and SCFs reinforcements. The outcomes of this work will aid the design/material engineers in making a good trade‐off between the mechanical and absorption properties of the proposed PETG nanocomposites.
The genetic approach to stillbirth: A »systematic review«
Authors: Dolanc Merc Maja , Peterlin Borut , Lovrecic Luca 
Published: April 2023

AbstractUnexplained stillbirth is defined as a stillbirth with no known cause after the exclusion of common causes, including obstetric complications, infections, placental insufficiency or abruption, umbilical cord complications, and congenital abnormalities with or without known genetic cause. More than 60% of stillbirth cases remain unexplained. The aim of this systematic review was to investigate the known genetic causes of unexplained stillbirth cases and to evaluate the current position and future directions for the use of genetic and genomic testing in expanding the knowledge in this field. A systematic search through several databases was performed using the keywords genetics and stillbirths in humans. Different methods to detect various types of causal genetic aberrations have been used in the past decades, from standard karyotyping to novel methods such as chromosomal microarray analysis and next generation sequencing technologies. Apart from common chromosomal aneuploidies, a promising hypothesis about genetic causes included genes related to cardiomyopathies and channelopathies. However, these were tested in the research settings, since molecular karyotyping is currently the standard approach in the routine evaluation of genetic causes of stillbirth. Hereby, we provide evidence that expanding knowledge using novel genetic and genomic testing might uncover new genetic causes of unexplained stillbirth.
Elucidation of the effect of hybrid copper/selenium nanofiller on the optical, thermal, electrical, mechanical properties and antibacterial activity of polyvinyl alcohol/carboxymethyl cellulose blend
Authors: Abdallah E. M. , Asnag G. M. , Morsi M. A. , Aljohani Marwah , Albalwa Aisha Nawaf , Yassin A. Y. 
Published: April 2023

AbstractPolymer nanocomposite samples of a polyvinyl alcohol (PVA)/carboxymethyl cellulose (CMC) blend doped with copper nanoparticles and selenium nanoparticles (Cu NPs/Se NPs) were prepared by the casting method. X‐ray diffraction analysis (XRD) patterns showed an increase in the degree of amorphous nature of the host polymeric matrix with increasing content of Cu/Se nanoparticles. The addition of 1.60 wt.%, Cu/Se NPs narrowed the indirect optical energy gap value of the nanocomposite from 3.97 to 2.39 eV. In addition, the differential scanning calorimetry (DSC) curve of the pure blend displays the miscibility of the blend components, confirmed by the presence of a single glass transition. Transmission electron microscopy (TEM) micrographs showed that the average sizes of Cu and Se nanoparticles are about 11 and 41 nm, respectively. The maximum values of AC and DC conductivity were 6.76 × 10−6 S.cm−1 and 5.49 × 10−10 for a PVA/CMC film filled with 1.60 wt.% of Cu‐Se NPs. The mechanical properties of the PVA/CMC blend improved after adding the hybrid NPs. Moreover, the antibacterial activity of the prepared samples was increased due to the filling of Cu‐Se nanoparticles to the films. Therefore, these results indicate the multifunctionality of PVA/CMC/Cu‐Se nanocomposite samples for use in electrical energy storage, solid‐polymer electrolytes, and food packaging industry.
Transcriptomic analysis of plasma exosomes provides molecular information of response to cabazitaxel treatment in men with metastatic castration‐resistant prostate cancer
Authors: Vardaki Ioulia , Özcan Seda Sabah , Fonseca Pedro , Lin Sue‐Hwa , Logothetis Christopher J. , Yachnin Jeffrey , Ullen Anders , Panaretakis Theocharis 
Published: April 2023

AbstractBackgroundProstate cancer is the second most common cancer type and the second most common cancer‐related cause of death in men. Cabazitaxel, a next‐generation taxane, shows favorable toxicity profile and is effective in docetaxel‐resistant tumors. Despite initial responses, in most cases, prostate cancer patients acquire resistance to cabazitaxel. There is a need to identify molecular markers that can monitor and predict treatment response.MethodsWe performed transcriptional exosome profiling (Human Transcriptome Array‐HTA 2.0) from the plasma of 19 patients with castration‐resistant prostate cancer at baseline and in patients after one cycle of cabazitaxel (C1). The patients were stratified in two groups (responders and nonresponders) according to their clinical response to cabazitaxel. Gene set enrichment analysis and ingenuity pathway analysis platforms were used for gene and pathway analysis.ResultsWe detected molecular differences in the exosomes from two groups of patients (nonresponders vs. responders) at baseline in pathways related to prostate cancer, oncogenic signaling, cytoskeleton, and immune system. In nonresponders, we found enrichment of cytoskeleton related gene (Stathmin‐1 and ITSN1) that have been associated with resistance to cabazitaxel. Monitoring of exosomal transcripts after the first cycle of treatment revealed changes in pathways associated with response to treatment.ConclusionsSequential transcriptional profiling of plasma‐derived exosomes reveals differential expression of genes that may reflect resistance to cabazitaxel treatment and therapy response.
Humoral immune response to two doses of COVID‐19 mRNA‐based vaccines in people living with HIV: A systematic review and meta‐analysis
Authors: Farhadian Negin , Sharifi Sara , Taghadosi Mahdi , Farhadian Maryam , Vaziri Siavash 
Published: April 2023

AbstractPeople living with HIV (PLWH) are susceptible to severe COVID‐19 infection and hence this fragile population has prioritised vaccination. This systematic review and meta‐analysis aimed to assess the humoral immune response after receiving two doses schedule of COVID‐19 mRNA vaccinations in this high‐risk population. A systematic electronic search on the PubMed database and manual searches were performed for relevant articles until 30 Sep 2022. Two outcomes of interest were seroconversion rates and anti‐spike receptor binding domain (anti‐S‐RBD) antibody titres at the median time of 14–35 days following two‐dose vaccination among PLWH. Nineteen cohorts and one cross‐sectional study were eligible for inclusion in this study. The pooled estimate of seroconversion rate after receiving two doses of mRNA vaccination schedule were 98.4% and 75.2% among PLWH with CD4>500 cells/mm3 and CD4<200 cells/mm3, respectively. Compared with controls, PLWH with CD4>500 cells/mm3 had a 51% likelihood of having positive anti‐Spike‐RBD immunoglobulin G (IgG) (OR: 0.509, 95% CI: 0.228, 1.133, p = 0.098) post‐vaccination and this value was only 1.4% (OR: 0.014, 95% CI: 0.002, 0.078, p = 0.000) for PLWH with CD4<200 cells/mm3. There was no significant difference in titres of antibodies on 14–35 days post‐vaccination between PLWH with CD4>500 cells/mm3 and healthy controls (p = 0.06). The pooled median of anti‐S‐RBD IgG values were 1461.93 binding antibody units (BAU)/ml and 457.41 BAU/ml in PLWH with CD4>500 cells/mm3 and CD4<200 cells/mm3, respectively. According to these findings, vaccination with both Pfizer‐BioNTech and Moderna vaccines induced a robust humoral response in ART‐treated HIV patients with preserved CD4 cell count. A diminished humoral immune response to vaccination against COVID‐19 in PLWH with unrestored CD4 count implied the need of specific vaccination schemes.
Silica‐Functionalized Nanolimes for the Conservation of Stone Heritage
Authors: Burgos‐Ruiz Miguel , Elert Kerstin , Ruiz‐Agudo Encarnacion , Cölfen Helmut , Rodriguez‐Navarro Carlos 
Published: April 2023

AbstractThe relatively recent development of nanolimes (i.e., alcoholic dispersions of Ca(OH)2 nanoparticles) has paved the way for new approaches to the conservation of important art works. Despite their many benefits, nanolimes have shown limited reactivity, back‐migration, poor penetration, and lack of proper bonding to silicate substrates. In this work a novel solvothermal synthesis process is presented by which extremely reactive nanostructured Ca(OH)2 particles are obtained using calcium ethoxide as the main precursor species. Moreover, it is demonstrated that this material can be easily functionalized with silica‐gel derivatives under mild synthesis conditions, thereby preventing particle growth, increasing total specific surface area, enhancing reactivity, modifying colloidal behavior, and functioning as self‐integrated coupling agents. Additionally, the formation of calcium silicate hydrate (CSH) nanocement is promoted by the presence of water, resulting in optimal bonding when applied to silicate substrates, as evidenced by the higher reinforcement effect produced on treated Prague sandstone specimens as compared to those consolidated with nonfunctionalized commercial nanolime. The functionalization of nanolimes is not only a promising strategy for the design of optimized consolidation treatments for the cultural heritage, but may also have important implications for the development of advanced nanomaterials for building, environmental, or biomedical applications.
EVA: a Tool for the Compositional Verification of AUTOSAR Models
Authors: Cimatti Alessandro , Cristoforetti Luca , Griggio Alberto , Tonetta Stefano , Corfini Sara , Di Natale Marco , Barrau Florian 
Published: April 2023

AbstractWe present , a framework for the integration of modern verification tools in the context of AUTOSAR, a widely-used open standard for the development of automotive software systems. Our framework enables the automatic end-to-end verification of system-level properties using a compositional approach. It combines software model checking techniques for the verification of software components at the code level with a contract-based analysis for verifying their correct composition. In this paper, we present the tool through its application on a representative automotive case study, discussing the main functionalities provided and the results obtained.
Bridging Hardware and Software Analysis with Btor2C: A Word-Level-Circuit-to-C Translator
Authors: Beyer Dirk , Chien Po-Chun , Lee Nian-Ze 
Published: April 2023

AbstractAcross the broad research field concerned with the analysis of computational systems, research endeavors are often categorized by the respective models under investigation. Algorithms and tools are usually developed for a specific model, hindering their applications to similar problems originating from other computational systems. A prominent example of such a situation is the area of formal verification and testing for hardware and software systems. The two research communities share common theoretical foundations and solving methods, including satisfiability, interpolation, and abstraction refinement. Nevertheless, it is often demanding for one community to benefit from the advancements of the other, as analyzers typically assume a particular input format. To bridge the gap between the hardware and software analysis, we propose Btor2C, a translator from word-level sequential circuits to C programs. We choose the Btor2 language as the input format for its simplicity and bit-precise semantics. It can be deemed as an intermediate representation tailored for analysis. Given a Btor2 circuit, Btor2C generates a behaviorally equivalent program in the language C, supported by many static program analyzers. We demonstrate the use cases of Btor2C by translating the benchmark set from the Hardware Model Checking Competitions into C programs and analyze them by tools from the Intl. Competitions on Software Verification and Testing. Our results show that software analyzers can complement hardware verifiers for enhanced quality assurance: For example, the software verifier VeriAbs with Btor2C as preprocessor found more bugs than the best hardware verifiers ABC and AVR in our experiment.
Lockstep Composition for Unbalanced Loops
Authors: Hamza Ameer , Fedyukovich Grigory 
Published: April 2023

AbstractEquivalence checking of two programs is often reduced to the safety verification of a so-called product program that aligns the programs in lockstep. However, this strategy is not applicable when programs have arbitrary loop structures, e.g., the numbers of loops vary. We introduce an automatic iterative abstraction-refinement-based technique for checking equivalence of a single-loop program and a program which has a series of consecutive loops. Our approach decomposes the single loop into a sequence of separate loops thus reducing the main problem to a series of equivalence-checking problems for pairs of loops. Since due to the decomposition, these problems become abstract, our approach iteratively refines the decomposed loops and lifts useful information across them. Our second contribution is a procedure for the alignment of loops with counters and explicit bounds that cannot be composed in lockstep. We have implemented the approach and successfully evaluated it on two suites, one with benchmarks containing different numbers of loops and the other containing benchmarks that need alignment.