bluuebunny/crossref_metadata_2025_split huggingface dataset:
LEVEL OF ALDEHYDIC AND KETONIC DERIVATIVES OF OXIDATIVELY MODIFIED PROTEINS IN THE BLOOD OF MEN AND WOMEN WITH MYOCARDIAL INFARCTIONS AND HYPOTHYROIDISM
Authors: Kurhaluk Natalia , Tota Krzysztof , Dubik-Tota Małgorzata , Tkachenko Halyna 
Published: January 2023

Oxidative stress and excessive reactive oxygen species production play considerable roles in infarction-induced injury impairing cardiac functions, as well as thyroid diseases.
Purpose: assessment of the oxidative stress markers, including oxidation of proteins [concentrations of aldehydic and ketonic derivatives of oxidatively modified proteins (OMB)] in the blood of individuals with hypothyroidism and/or myocardial infarction living in the Central Pomerania.
Methodology. The level of oxidative stress markers was assessed among 225 individuals, i.e. 132 males (58.67%) and 93 females (41.33%) aged 35-71 years residing in Central Pomerania. In the obtained plasma, an assessment of levels of aldehydic and ketonic derivatives of oxidatively modified protein analyses was carried out.
Scientific novelty. The highest level of aldehydic and ketonic derivatives of oxidatively modified proteins was found in the group of males with myocardium infarctions and hypothyroidism compared to other groups. In females, an increase in aldehydic and ketonic derivatives was observed in the group with myocardial infarctions and in the group with hypothyroidism compared to the control group, while a decrease in aldehydic and ketonic derivatives was observed in subjects with myocardial infarction compared to individuals both with myocardial infarctions and hypothyroidism. In males, an increase in aldehydic and ketonic derivatives in both groups with myocardial infarctions and with hypothyroidism compared to the control group was observed, while in relation to the individuals with myocardial infarctions and hypothyroidism there was a decrease in aldehydic and ketonic derivatives in the group with myocardial infarctions and a decrease in ketonic derivatives in individuals with hypothyroidism. In addition, a decrease in the level of ketonic derivatives in the males with myocardial infarction and hypothyroidism compared to the group of females was observed.
Conclusions. In the course of myocardial infarction, gender affects the level of the aldehydic derivatives of oxidative modification of proteins. Among individuals with hypothyroidism, the increase of ketonic derivatives of oxidatively modified proteins is also affected by sex. Analysis of oxidative stress markers depending on the sex may provide a biochemical basis for epidemiological differences in susceptibility to disease between sexes and suggest different strategies for risk assessment, diagnosis, and treatment specifically targeted at groups of males and females of different ages.
Telemedicina: oportunidades para administradores
Authors: Cruces Cristian Guajardo , Navarro Carlos Torres , Espinosa Fredy Troncoso , Riquelme Juan Maldonado 
Published: January 2023

Este trabajo describe el área de la telemedicina como herramienta de gestión para el sistema público de salud en Chile. Se incluye las tres áreas relevantes como lo son la descripción de los procesos involucrados, las tecnologías de la información utilizadas y los diversos recursos humanos y materiales necesarios para aumentar la calidad de los servicios ofrecidos a los pacientes a través de los hospitales públicos en la Octava región en Chile. Se describe un proyecto de teleasistencia financiado por organismos del Estado y se muestran sus resultados preliminares. Además se identifican áreas futuras de desarrollo con el fin de incentivar a profesionales de la ingeniería para que se involucren en la investigación y desarrollo del sistema público de salud.
Molecular Characterization of Carbapenemase Encoding Genes in Pseudomonas aeruginosa from Tertiary Healthcare in South Eastern Nigeria
Authors: Ogba Rebecca Chinenye , Nomeh Onyinye Lovette , Edemekong Christiana Inuaesiet , Nwuzo Agabus Chidiebube , Akpu Peace Oluchi , Peter Ikemesit Udeme , Iroha Ifeanyichukwu Romanus 
Published: January 2023

Background and Objectives: In recent years, the rate of carbapenemase encoding gene in P. aeruginosa has increased worldwide and has become of great concern since it’s significantly restricts the therapeutic options for patients in Tertiary health care. Therefore, there’s a need for molecular characterization of carbapenemase encoding genes in Pseudomonas aeruginosa from Tertiary Healthcare in South Eastern Nigeria.
Methodology: A total of twelve (12) Pseudomonas aeruginosa positive culture of Urine (n=5), Wound swab (n=5), Catheter tip (n=2) were collected from Alex Ekwueme Federal University Hospital Teaching Hospital, Abakaliki (AE-FUTHA), Ebonyi State, South eastern Nigeria. The Pseudomonas aeruginosa strain confirmation was performed using VITEK 2 System and the bacteria were further screen for carbapemase encoding gene by PCR specific primer.
Results: Molecular amplification of carbapenemase encoding genes revealed that blaNDM and blaIPM accounted 12 (100%) across all sample source. Among the various sample sources, blaKPC was found 1(8.3%) in Urine, wound swab 3(25.0%), and Catheter tip 1(8.3%), while blaVIM was found 2(16.7%), 2(16.7%) and 0(0.0%) in Urine, wound swab and Catheter tip respectively. Co-expression of blaNDM + blaIMP accounted 5(41.6 %), 5(41.6 %) and 2(16.7 %) in Urine, wound swab and Catheter tip respectively. Co-expression of blaKPC + blaNDM + blaVIM + blaIMP + blaOXA was only detected in urine 1(8.3 %).
Conclusion: The current study gives an account of the presence of carbapenemase-encoding genes in P. aeruginosa. The expression of carbapenemase-encoding genes may be the mainstay of phenotypic MDR. As a result, physicians, other medical professionals, researchers, and public health policymakers must be kept up to date on the spread of carbapenemase-encoding genes. In addition, strict infection prevention and control strategies, as well as antimicrobial stewardship programs, are highly desirable in admission healthcare facilities where carbapenemase-encoding genes are spreading.
TREAT-B has Good Accuracy in Selecting HBV Infected Patients for Treatment in Sudan
Authors: Elhasan Mogahid Mahmoud , Kheir Omer Osman , Patwa Yashwi Haresh , Bakhit Aya Tarig , Abdalla Hala Ibrahim 
Published: January 2023

Non-invasive and invasive diagnostic methods, which are not readily available in Sudan, are used to guide HBV treatment. Africa adopted the TREAT-B as a straightforward score in 2018 to identify patients in need of anti-HBV treatment.
Objective: To compare the diagnostic accuracy of the TREAT-B score to the standard scores EASL and AASLD in HBV patients.
Methods: At Ibn Sina Specialized Hospital, 108 HBV patients were enrolled in an analytical cross-sectional study (January- October 2019). Data was collected using an interviewer-administered questionnaire and analyzed using SPSS.
Results: Eight patients (7.4%) were eligible for therapy under the AASLD recommendations, 18 patients (16.7%) were suitable under the EASL guidelines, and twenty-seven patients (25%) were eligible under the TREAT-B guidelines. According to the Wald statistic, the AUROC of TREAT-B (0.883; 95% CI 0.790-0.976; Sen. 85.3%; Sp. 70.3%) was substantially higher than the AUROC of the AASLD criteria (0.722; 95% CI 0. 0.566-0.878; Sen. 74.4%; Sp. 69.8%); and lower than the AUROC of the EASL criteria (0.952; 95% CI 0.790-0.976.
Conclusion: The TREAT-B score was effective at identifying HBV-infected patients who should receive antiviral treatment.
Analysis of Quality Control of Tea Products Using the Fishbone Diagram Approach at Pt Candi Loka, Indonesia
Authors: Durroh Badiatud , Daud Moch. Yusuf , Purba Jhon Hardy 
Published: January 2023

In the current era of globalization, there are many similar products on the market and most of them have same prices and functions. Thus, the only factor that can be used as a differentiator from similar products is the quality of the products. This research was conducted at PT Candi Loka, which is engaged in agribusiness, namely tea processing. This research aims to (1) determine the problems faced by PT Candi Loka as related to the quality of tea production, (2) identify the factors that most influence the quality of tea at PT Candi Loka, and (3) formulate the most appropriate solution to be applied in an effort to improve the quality of tea production at PT Candi Loka. The basic method in this research was the descriptive method with a qualitative approach. Data analysis was performed through using the techniques of check sheet, stratification, pareto charts, and fishbone charts. The results of this study comprised the Pareto diagram that showed the existence of deviations in the quality of dry tea products produced in March 2022, namely the pekoe products had lower quality than the standards set by the company. Check sheets and stratification showed the factors that influenced the quality of tea products at PT Candi Loka, namely (a) human factor, which included: lack of care in applying drying temperature, inadequacy of labor knowledge, lack of worker discipline, the large number of workers who were at unproductive age, lack of work contracts between the plantation foreman and the pickers; (b) raw materials, which included: damaged and rough (old) materials, the large number of plants that were not productive; (c) work method, which included: unstable withering and drying temperatures, non-specialized work systems, sales based on order system; (d) machine, which included: overly old machines, dirty machine conditions; (e) environment, which included: uncertain weather and temperature, decreasing soil fertility. Fishbone analysis was used to determine the most dominant factors in the final product, namely pekoe with inferior standard. The factors that influenced the pekoe products with lower standard consisted of damaged and rough (old) shoots and unstable temperature during processing (withering and drying). From the results of the analysis, recommendations are offered for improvements that can be implemented by PT Candi Loka, namely improving its picking system to improve the quality of raw materials, providing appropriate temperatures at the processing stage (withering and drying) and making quality manuals based on performance.
Ethnobotanical and Floristic Investigations of Datura Species in Mali
Authors: Togola Issiaka , Konaré Mamadou Abdoulaye , Diarra Nouhoum , Karembé Moussa 
Published: January 2023

Aims: This work aimed to investigate the floristic composition and the different medicinal uses of Datura species in addition to people perceptions about them.
Place and Duration of Study: The floristic study has been conducted in three sites located in the region of Sikasso (Mali) during October, 2019. The ethnobotanical one was carried out in five zones located in different regions of Mali in order to register the maximum of relevant information about Datura’s therapeutic virtues.
Methodology: A floristic and ethnobotanical investigation on Datura species was carried out based on a stratified probabilistic sampling plan. The free consent and the availability of the respondents was an important criterion during the ethnobotanical survey. Besides, the characteristic parameters of floristic diversity and relative frequencies were calculated based on literature formula.
Results: The floristic survey allowed to register three species of Datura: D. stramonium (65.38%), D. innoxia (19.23%) et de D. ferox (15.38%). Around these species, 148 plants belonging to 39 species divided in 32 genus and 18 families. Herbaceous represented 94.87% of these inventoried species. With high coefficients of similarity (Cs>50%), we noted an identical floristic diversity inside the three sites. Moreover, Tousseguela had the highest specific diversity index (1.21). The ethnobotanical survey targeted 118 people in five 5 localities with about 77% of men. If 50% of them found Datura to be useful, 50% considered it to be useful with distrust or dangerous. The data showed that the local populations use Datura in the treatment of many diseases; the most cited were dermatosis (16.98%) and swelling (14.15%). The leaves (93.83%) and seeds (14.81%) were the most exploited organs mainly in the form of decoction (61.18%) and by oral route, massage (15.66%) and bath (13.25%).
Conclusion: These results reveal the floristic richness of Datura genus and its associated species.
Nutritional and Functional Properties of Wheat-Defatted Peanut-Orange Peel Composite Flour
Authors: Bongjo Ndi Betrand , Aondoaver Ahemen Samuel , Gbertyo Joseph Aondoaver , Fulai Ayong Mary Assumpta , Nchung Lorita 
Published: January 2023

The need to improve and enhance the nutritional quality of locally made foods (bakery and confectionaries) cannot be overemphasized. This study set out to meet this need by producing composite flours from wheat, defatted peanut and orange peel flour blends which will serve an even greater issue of reducing the cost of wheat importation and use. The samples were coded as follows: A-100:0:0, B-90:5:5, C-85:10:5, D-80:15:5, E-75:20:5 of wheat flour: Defatted peanut flour: orange peel flour. The flours produced were analyzed for functional, anti-nutrient, proximate, minerals, and phytochemical properties. The functional properties of flours; bulk density, swelling capacity, OAC, WAC, and Foaming capacity ranged from 0.43 to 0.93 g/ml, 0.89 to 5.67%, 0.47 to 2.55 g/L, 1.75 to 4.35ml/g, 0.52 to 10.56% respectively. The anti-nutritional properties: phytates, tannins, and trypsin inhibitor content of flours ranged from 0.0352 to 0.0845%, 0.040 to 0.600%, and 0.011 to 0.048mg/g respectively. The proximate composition of the flour samples, Moisture, Protein, fats, crude fibre, ash, carbohydrates, and energy values ranged from 5.58 to 9.55%, 6.33 to 15.64%, 1.06 to 3.51%, 0.24 to 4.07%, 1.42 to 2.65%, 85.37 to 64.58% and 376.34 to 352.47kcal/100g respectively. The mineral composition in the samples ranged from 232.05 to 394.62mg/100g for Ca, 76.09 to 122.27mg/100g for Mg, 6.71 to 29.42 mg/100g for Fe, 108.78 to 256.47mg/100g for K, 10.09 to 25.75 mg/100g for Zn. The phytochemical composition of the samples was as follows; 0.067-0.153%, for saponins; 0.043-1.457%, for alkaloids; 1.03-13.77mgGAE/g, for Total phenolics; 3.07-29.31mg/QE, for Total Flavonoids respectively. The composite flour herein produced demonstrates great potential for its use in the development of functional foods given its great nutrients and improved functional characteristics. However sample E with 75%wheat: 20%DPF: 5%OPF surpassed all other samples in terms of the quality attributes and therefore was the best of the formulations.
Determining Length of Growing Period for Crop Planning in East and South Eastern Coastal Plain Agroclimatic Zone of Odisha
Authors: Dugal D. , Mohanty T. R. , Panigrahi G. , Mohapatra A. K. B. , Nanda A. , Swain S. K. , Samant P. K. 
Published: January 2023

The length of the growing period (LGP) refers to a number of days in a year during which the moisture at the root zone of crop plants is adequate to meet the crop water need. Information on LGP provides a basis for the selection of crops, cultivars (short / medium / long duration) and cropping/farming systems of a region.
Aim: The study aims to estimate the length of crop growing season of the East and South Eastern Coastal Plain Agroclimatic Zone of Odisha in order to provide a basis for suitable crop planning for the region.
Methodology: The LGP for four districts (Jagatsinghpur, Kendrapara, Khordha and Puri) under East and South Eastern Coastal Plain Agroclimatic Zone of Odisha was estimated using rainfall data of 30 years (1991 to 2020). The growing season begins when the sum of daily rainfall (forward accumulation) reaches 75 mm (28 May, 29 May…15 Oct) and ends when backward accumulation (15 Oct, 14 Oct,……, 28 May) of 20 mm reach. The LGP was worked out by adding the duration of the rainy season with the sum of post-monsoon rainfall and the average water-holding capacity of soil divided by the post-monsoon PET of the district.
Results: LGPs obtained by the above method varied from 173 to 192 days in this zone with Kendrapara district having the highest LGP (192 days) and Khordha the shortest (173 days). The date of onset and cessation of south west (SW) monsoon was 15-17 June and 13 October, respectively.
Conclusion: Double cropping can be followed in Jagatsinghpur, Kendrapara and Puri districts where the length of the growing period >180 days except Khordha district where paira cropping can be followed as the length of the growing period <180 days.
Integrated Nutrient Management to increase Productivity and Profitability in Dual Purpose Oat (Avena sativa L.)
Authors: Suryabhan . , Yadav R. S. , Kumar Mukesh , Prajapati Akhilesh Kumar , Prajapati Sunil Kumar , Patel Kuldeep , Verma Shikhar 
Published: January 2023

Field experiments were carried out to Study the Integrated Nutrient Management to increase Productivity and Profitability in Dual Purpose Oat (Avena sativa L.) at Genetics and Plant Breeding Research Farm, Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya, Uttar Pradesh (UP), during Rabi season 2018-19. The experiment was laid out in Randomized block design (RBD) with three replications and nine treatments viz., T1: Control, T2: RDF (100 kg N : 40 kg P2O5 : 40 kg K2O ha-1), T3: 75 % RDN + Vermicompost @ 2t ha-1, T4: T3 + PSB (soil application @ 1.5 kg ha-1), T5: T4 + Azotobacter (seed treatment @10g kg-1 seed), T6: T5 + ZnSO4 @ 20 kg ha-1 (soil application as basal ), T7: T5+ ZnSO4 @ 15 kg ha-1 (soil application as basal), T8: T6 + Foliar spray of ZnSO4 (0.5%) at just before flowering, T9: T7 + Foliar spray of ZnSO4 (0.5%) at just before flowering. Results revealed that higher yield attributes viz. panicle length (37.40cm), panicle weight (9.80g), number of grain panicle-1 (56.33), test weight (48.70g), green forage yield (90.60 q ha-1), dry matter yield (17.51 q ha-1), yield parameters viz. grain yield (16.51 q ha-1), straw yield (72.97 q ha-1) and profitability viz. gross income (INR 82069.5 ha-1), net income (INR 51605.5 ha-1) and B:C ratio (1.69) of oat for T8: 75% RDN + Vermicompost @ 2t ha-1 + PSB (soil) @ 1.5 kg ha-1 + Azotobacter (seed treatment) @ 10 g kg-1 of seed + ZnSO4 @ 20 kg ha-1 (basal) + foliar spray of ZnSO4 (0.5%) at just before flowering of oat as compared to the control. Whereas, application of organic and inorganic fertilizers in combinations viz., Nitrogen, Phosphorus, Potassium, Vermicompost, Phosphorus Solubilizing Bacteria (PSB), Azotobacter and Zinc had a significant effect on total biomass production, yield attributes, yield and profitability of oat.
A Review – Some Approaches to Combat Salt Stress in Wheat Crop
Authors: Khasa Ritu , Kumar Sushil , Devi Sudesh , Dagar Harender 
Published: January 2023

Wheat constitutes a central position for ensuring food and nutritional security; however, rapidly rising soil and water salinity pose a serious threat to its production globally. Salinity stress is a universal dilemma that is happening due to climate change. It affects hectares of arable land. Main focus regarding improving salinity tolerance in plants has been given to Na+ exclusion/ Na+ compartmentalization and enhanced ROS system. Besides this, ameliorative activity of phytohormones, nutrients, amino acids and organic osmolytes has also been widely studied. Exploring traits in wild genotype aids search for better solutions. Based upon phenotype screening, novel genes involving salinity tolerance will be easily identified. Moreover, selected mutants can be used to validate the functions of salt genes. Wheat plants utilize a range of physiological biochemical and molecular mechanisms to adapt under salinity stress at the cell, tissue as well as whole plant levels to optimize the growth, and yield by off-setting the adverse effects of saline environment. Recently, various adaptation and management strategies have been developed to reduce the deleterious effects of salinity stress to maximize the production and nutritional quality of wheat. Thereby, this review highlights effects of salt tolerance, physiological mechanisms behind salt tolerance and transgenic wheat that are potential indicators of salinity stress tolerance.
Diacetyl - A Critical Safety Review of the Science Defining the Environmental Inhalation Hazards Association with Chronic Lung Disease
Authors: Mink Franklin L. 
Published: January 2023

In the last two decades scrutiny of several retrospective occupational studies on performed by NIOSH in the early 2000’s on ambient indoor air exposures to the flavoring chemical diacetyl and more complex butter flavoring formulations has led to a reported association between diacetyl and severe irreversible lung disease, primarily bronchiolitis obliterans. A group of laboratory rodent studies, performed primarily by associated researchers, followed in the next two decades with the intent to determine a plausible physiological mechanism for bronchiole scarring applicable to the human respiratory tract. Recently, a renewed interest in diacetyl as a flavoring constituent of vaping liquids and marijuana and inhalation exposures has emerged. This paper reviews the universe of published literature to date in relation to whether diacetyl or butter flavors containing diacetyl causes occupational or environmental lung disease, more specifically BO (i.e., general causation) and whether specific levels of inhaled diacetyl or butter flavors containing diacetyl are associated with chronic lung disease.
The review included numerous journal articles, government reports, etc. Based upon the evidence, while the literature reflects a statistical association between both diacetyl and butter flavoring diacetyl mixtures and lung disease, there is sufficient evidence to conclude that general causation between exposure to diacetyl concentrations measured in the ambient air environments studied to date and chronic lung disease does not exist.