bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant Lenvatinib in Combination with Transarterial Chemoembolization for Hepatocellular Carcinoma Patients with High-Risk of Postoperative Recurrence: A Prospective Cohort Study
Authors: Chen Jinhong , Lu Lu , Zhang Xiaoyun , Xiang Bangde , Xu Xiao , Li Xiangcheng , Huang Zhiyong , Wen Tianfu , Luo Liuping , Huang Jing , Zhong Jian-Hong , Liu Zhikun , Li Changxian , Long Xin , Zhu Wenwei , Yang Xin , Wang Chaoqun , Jia Huliang , Zhang Jubo , Zeng Yongyi , Lu Caide , Qin Lun-Xiu 
Published: July 2023

Abstract
Background
The high probability of tumor recurrence after curative surgery hinders the survival of patients with hepatocellular carcinoma (HCC). This prospective cohort study aimed to evaluate the efficacy and safety of lenvatinib (LEN) plus transarterial chemoembolization (TACE) as an adjuvant therapy in pre-defined HCC patients with high-risk of postoperative recurrence.
Methods
Patients who met the eligible criteria were enrolled between November 2018 to May 2021 from 8 hepatobiliary centers in China. The primary endpoint was disease-free survival (DFS). The secondary endpoints were overall survival (OS) and safety. Additionally, propensity score matching (PSM) and other propensity score analyses were performed to balance the potential confounding factors between groups to validate the conclusion. The treatment-related adverse events (AEs) were recorded throughout the entire study period.
Results
A total of 297 patients were enrolled, with 147 patients in the LEN + TACE group and 150 patients in the TACE group. Before PSM, patients in the LEN + TACE group achieved significantly better DFS than those in the TACE group (19.0 vs. 10.0 months, P = 0.011). PSM analysis identified 111 matched pairs of patients. LEN + TACEgroup also showed longer DFS in than the TACE group after PSM (19.0 vs. 9.0 months, P = 0.018). Further other three propensity score analyses yielded similar DFS benefit tendency after the potential confounding factors were adjusted in two groups. Although the median OS had not been reached in either of the two groups, both primary cohort and PSM cohort showed favorable OS benefit tendency in the LEN + TACE group. Intrahepatic recurrence was the most common recurrent location in both groups. Lenvatinib treatment-related AEs of grade 3 or 4 occurred in 28.6% of the patients in LEN + TACE group.
Conclusions
This study suggested that adjuvantlenvatinib plus TACE might be a promising approach for HCC patients with high-risk of postoperative recurrence, which could significantly reduce postoperative recurrence and prolong survival with a manageable safety profile.
Trial Registration ClinicalTrials.gov Identifier: NCT03838796.
Alternative meats and alternative facts
Authors: Van Eenennaam Alison L. 
Published: July 2023

The alternative animal product arena is complex and quite var­ied. Some plant-based alternative meat products are derived entirely from plants. Other entrepreneurs are using cultivated cells of animal origin to derive a product structurally similar to meat and milk and comprised of animal proteins. Many of these endeavors use a combination of both approaches with the plant-based product providing filler for the cultivated meat or milk product. Most of the discussion around alternative meats has focused on bovine alternatives because of the iconic position of cattle in many climate and sustainability discussions. A consid­erable amount of capital has been raised based on the
envisioned market share of these products, although estimates vary widely, and the high profile initial public offering of Beyond Meat shares in May 2019 which saw share prices soar from $75 to $235, has this year seen share prices plummet to about one-tenth of that highest price. Proponents of alternative meats suggest these production systems are more sustainable based on antici­patory greenhouse gas emission (GHG) and land use life-cycle assessment (LCA)/kilogram (kg) of product, as compared to LCA metrics for ruminant meat. Much of the rationale
invokes a simplistic narrative around GHG/kg of protein. The GHG “sustainability” metric will invariably reflect poorly on ruminants as they are uniquely able to digest cellulose through their rumen microbes, and the methanogens produces methane which is a potent but short-lived greenhouse gas. And because ruminants are typically grazing in marginal land unsuitable for producing crops, they also have a high land use m2/kg of protein. However, there is no reason to conclude that food production on well-managed pasture and rangeland is, a priori, less sustainable than food production of well-managed arable cropland. More­over, the other sustainability externalities of ruminant meat production systems such as the provision of ecosystem services and biodiversity conservation, the consumption of inedible food waste and cellulose, manure, transportation, contributions to the livelihoods and food security of 1.3 billion livestock keepers, the fact that meat provides nutrients in addition to protein, and that existing harvesting systems utilize everything but the “moo” are often ignored or simply disregarded.
FAKTOR-FAKTOR YANG MEMPENGARUHI KETEPATAN WAKTU PENYAMPAIAN LAPORAN KEUANGAN (STUDI EMPIRIS PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI PERIODE 2018-2020)
Authors: Sari Novita , Gowon Muhammad , Yustien Reni 
Published: July 2023

Penelitian ini bertujuan untuk menemukan bukti empiris tentang pengaruh dari Profitabilitas, Debt Equity ratio, Likuiditas, Umur Perusahaan, Kualitas Auditor, Opini Audit, dan Ukuran Perusahaan terhadap ketepatan waktu penyampaian laporan keuangan pada perusahaan manufaktur yang terdaftar di bursa efek Indonesia (BEI) untuk periode 2018sampai 2020.Jenis penelitian yang digunakan adalah penelitian kuantitatif dengan menggunakan data skunder. Berdasarkan metode pengambilan sampel dengan menggunakan purposive sampling , maka didapat sampel sebanyak 30 perusahaan, sehingga jumlah sampel perusahaan dari tahun 2018 sampai 2020 adalah sebanyak 90 sampel. Data yang digunakan dalam penelitian ini adalah data dari laporan keuangan perusahaan manufaktur yang dipublikasikan di website resmi www.idx.co.id tahun 2018-2020. Pengujian hipotesis menggunakan analisis regresi linear berganda.
Hasil penelitian ini menunjukkan bahwa Profitabilitas, Umur Perusahaan, Kualitas Auditor, Opini audit, dan Ukuran Perusahaan berpengaruh Signifikan terhadap ketepatan waktu penyampaian laporan keuangan, sedangkan Debt Equity Ratio, dan Likuiditas tidak berpengaruh terhadap ketepatan waktu penyampaian laporan keuangan. Variabel independen dapat menjelaskan pengaruh ketepatan waktu penyampaian laporan keuangan sebesar 41,10% sedangkan sisanya 58.9% dipengaruhi oleh faktor lain yang tidak dimasukkan dalam model regresi ini.
Study on Secular Change of the Earth’s Rotation Rate Based on Solar Eclipse Observation Records on October 13, 443 BC
Authors: MA Lihua 
Published: July 2023

ABSTRACT
An observation of a solar eclipse that occurred on October 13, 443 BC during the reign of the Duke Ligong of Qin was recorded in the Twenty-Four Histories (China’s dynastic histories from remote antiquity till the Ming Dynasty). With modern astronomical planetary ephemeris, the observation records were studied. The results showed that the eclipse probably occurred around sunset in Yongcheng, the capital of Qin, where the sunset time was exactly between the first contact stage (partial eclipse begins) and the fourth contact stage (partial eclipse ends) of the eclipse. Furthermore, secular change of the earth’s rotation rate at that time is investigated in this work.
Influence of glass dealkalization on the quality of adhesion of bonded materials
Authors: Kordová T. , Mareška A. , Míka M. Havlík 
Published: July 2023

AbstractThe aim of this paper is to determine the effect of dealkalization of the glass surface on the quality of adhesion of bonded parts to the glass. Most of the available studies on glass dealkalization tend to focus only on the properties of the glass itself and the processes taking place in the surface layers of the glass. However, in practice focused on adhesion, the cleanliness of the glass surface is an important factor, which is influenced, among other things, by dealkalization. In this work, the influence of the use of gaseous SO2in the furnace on the composition of the glass surface and on the resulting adhesion is assessed. Regarding the deterioration of the adhesion quality between the glass treated with SO2gas and the adhesion promoter, the cleaning efficiency of the glass surface was further tested, according to the results of the cross-cut test.
The use of an endovascular balloon to increase the safety of laparoscopic decompression of the abdominal trunk
Authors: Khamid Z. M. , Bazunov A. K. , Biryukov A. V. , Vasilevsky D. I. , Korolkov A. Yu. , Balandov S. G. , Puzanov S. Yu. , Rumyantsev I. P. , Bagnenko S. F. 
Published: July 2023

The OBJECTIVE was to increase the safety of laparoscopic decompression of the abdominal trunk.METHODS AND MATERIALS. The results of treatment of 30 patients who underwent laparoscopic decompression of the celiac trunk were analyzed. Intraoperative bleeding requiring conversion to laparotomy occurred in two (6.7%) cases.RESULTS. To prevent such a complication, a method of preventive installation of a balloon catheter into the celiac trunk was introduced, which allows creating a temporary occlusion of the vessel in case of damage. A similar approach was used in 10 (33.3%) patients. The need to cover the lumen of the vessel with a balloon arose in one observation (3.3% of all patients and 10.0% using this technique). Bleeding from the inferior phrenic artery, which originated from the celiac trunk, was stopped by laparoscopic access.CONCLUSION. The experience presented in this paper allows us to consider the installation of a balloon boat in the celiac trunk as one of the possible ways to improve the safety of its laparoscopic decompression. Further research is needed to obtain a definitive picture of the effectiveness of this approach.
“Where ladies are so scarce we have to muster in full”: Sophie Porter’s Account of Over–Wintering at Herschel Island, 1894-1895
Authors: Lackenbauer P. Whitney 
Published: July 2023

Sophie E. Porter’s account offers colourful insights into the life of the whaling community over–wintering at Herschel Island (Qikiqtaruk) in the mid–1890s. Porter lived on board the whaling ship Jesse H. Freeman in the winterized quarters prepared for her husband, but her full social schedule meant that the ship did not keep her captive. The excerpts transcribed, reproduced, and introduced in this commentary span the period from 19 August 1894 (when Jessie H. Freeman dropped anchor off the sand spit at Herschel) to Victoria Day (24 May) 1895. Porter’s account offers rare insights into how women and other members of the diverse Herschel Island community negotiated gender, race, and class positions and coped with life in this remote Arctic outpost.
Le récit de Sophie E. Porter offre un aperçu imagé de la vie de la communauté baleinière qui a passé l’hiver à l’île Herschel (Qikiqtaruk) au milieu des années 1890. Porter vivait à bord du baleinier Jesse H. Freeman dans les locaux aménagés pour l’hiver préparés pour son mari, mais son calendrier d’activités sociales était chargé même si elle était à bord d’un navire. Les extraits transcrits, reproduits et présentés dans cet exposé couvrent la période du 19 août 1894 (lorsque le Jessie H. Freeman a jeté l’ancre près de la flèche de sable à l’île Herschel) à la fête de la Reine du 24 mai 1895. Le récit de Porter offre un regard unique sur la façon dont les femmes et les autres membres de la communauté hétérogène de l’île Herschel déterminaient leurs positions de genre, de race et de classe et faisaient face aux difficultés de la vie dans cet avant–poste isolé de l’Arctique.
PRODUCTION OF BIOETHANOL FROM BANANA PEEL (Musa paradisiaca l.) USING SULFURIC ACID CATALYST
Authors: Zulnazri Zulnazri , Maulana Arif , Muarif Agam , Sylvia Novy , Dewi Rozanna 
Published: July 2023

.Bioethanol is a pure alcoholic compound consisting of ethanol and is produced through a biomass fermentation process with the help of microorganisms. Making bioethanol can be done using plants that contain starch, carbohydrates, glucose, and cellulose. One option is kepok banana peels. Utilization of kepok banana peels can increase the variety of raw materials for bioethanol production which are cost-effective and easy to obtain. This research has been done before, what has never been done is the manufacture of bioethanol using various catalysts H2SO4, hydrolysis temperature and fermentation time. This research method uses hydrolysis, fermentation and distillation with variations in hydrolysis temperatures of 80°C, 90°C and 100°C, variations in catalyst concentration H2SO4 1 M, 2 M, 3 M with fermentation times of 5, 7, 9 days. Results of this study the highest yield and density were obtained at the hydrolysis temperature of 90°C, the catalyst concentration of 3 M H2SO4 with a fermentation time of 9 days was 5.0432% and 0.8346 gr/ml, and the highest bioethanol content was at the hydrolysis temperature of 90°C, the catalyst concentration 2 M H2SO4 with 9 days fermentation time of 0.2884%. The size of a grade is influenced by the length of time of fermentation and the amount of catalyst given. The density value of the bioethanol obtained meets the Indonesian National Standard. The results of the GC (Gas-Chromatography) test based on the highest glucose content and fermentation time at each temperature variation showed that the bioethanol content with a glucose content of 5.2%, 12.2% and 14.1% respectively at a hydrolysis temperature of 80°C , 90°C and 100°C with catalyst concentration H2SO4 3 M and a fermentation time of 9 days, namely 1.783%, 4.024% and 5.030%. The greater the catalytic agent used, the greater the level of glucose produced and the longer the fermentation period given, the more optimal the product will be.
Efecto del aceite esencial de orégano y sus fracciones concentradas en el crecimiento de Aspergillus brasiliensis (niger)
Authors: Cazares-Rodríguez A.G. , Rodríguez-Rodríguez J. , Sánchez-García E. , De Lara-Novella J. , García-Alanís K. , Leos-Rivas C. , Castillo-Hernández S. 
Published: July 2023

La inocuidad de los alimentos es una necesidad crítica a nivel mundial. Algunos hongos deteriorantes como Aspergillus brasilienis (niger) producen micotoxinas en las materias primas (granos principalmente) y esto llega al alimento terminado, provocando complicaciones en la salud. La incidencia de brotes en los alimentos obliga a investigar nuevos métodos para la conservación alimentaria, por otro lado, también existe una gran demanda de productos naturales, es por esto, que el uso de aceites esenciales como conservadores naturales cobra especial importancia en la industria alimenticia, ya que éstos son reconocidos como seguros (GRAS) para ser usados en alimentos. Los aceites esenciales de orégano constituyen una alternativa como potenciales agentes antioxidantes y antimicrobianos prolongando la vida útil. El objetivo del presente estudio fue evaluar los efectos de las fracciones concentradas de orégano sobre el crecimiento de A. brasiliensis (niger). Se realizaron pruebas de difusión en disco, determinación de la concentración mínima inhibitoria (CMI), concentración mínima fungicida (CMF) y evaluación morfológica del hongo a concentraciones menores a la CMF. Los resultados muestran una actividad antimicrobiana con halos de inhibición en rangos de 3.6-5.8 cm. La CMI y CMF mostraron rangos de 6 a 600 ppm, mientras que la evaluación morfológica, evidenció una alta inhibición de la conidiogénesis.
Titanium Microtexture 101, Part I
Authors: Harr Michelle , Pilchak Adam , Semiatin Lee 
Published: July 2023

Abstract
Despite decades of research, fundamental questions still exist regarding the role of microtexture on the deformation, fatigue, and fracture behavior of titanium alloys. This article describes the microstructural evolution processes that result in microtexture formation, while Part II of this series will further elaborate on the effects of microtexture on deformation behavior.
Kinetics of Thermal Pyrolysis of High-Density Polyethylene
Authors: Abbas Ammar S. , Saber Marwa G. 
Published: July 2023

Thermal pyrolysis kinetics of virgin high-density polyethylene (HDPE) was investigated. Thermal pyrolysis of HDPE was performed using a thermogravimetric analyzer in nitrogen atmosphere under non-isothermal conditions at different heating rates 4, 7, 10 °C/min. First-order decomposition reaction was assumed, and for the kinetic analysis Kissinger-Akahira-Sunose(KAS), Flynn-Wall-Ozawa(FWO) and Coats and Redfern(CR) method were used. The obtained values of average activation energy by the KAS and FWO methods were equal to137.43 and 141.52 kJ/mol respectively, these values were considered in good agreement, where the average activation energy value obtained by CR equation methods was slightly different which equal to 153.16 kJ/mol.
A Multimodal Discourse Analysis of Visual Illustrations Related to COVID-19 Awareness in Nigeria
Authors: AMODU Abideen David , OTESILE Ayodeji Ebunoluwa 
Published: July 2023

The current paper aims to discuss the impact of visual illustrations related to the COVID-19 pandemic in Nigeria. To embark, this study utilizes visual resources, precisely images to facilitate a massive audience by incorporating various modes of visual communication, such as graphics, typography, and attractive layouts to engage the public. This study deploys a multimodal discourse analysis of selected COVID-19 pandemic visual illustrations. The current study examines ten (10) COVID-19 visual illustrations. These /visual illustrations were collected from the official website of the Nigeria Centre for Disease Control (NCDC). This research identified that in creating awareness concerning the spread of the COVID-19 pandemic and its mitigation, there is a dire need to enhance modes of communication using multiple modes of awareness, such as images such as graphics, typography, and other semiotic resources. To elaborate further a large range of visual resources were utilized to analyse the linguistic efficiency of selected visual resources to communicate with the larger audience with concise language and expression. When multiple modes are used effectively in the images, they become audience-affective, such that the attention of the reader or target audience is drawn to the content of the image. Moreover, this study recommended that to achieve the maximum effect of awareness concerning the COVID-19 pandemic, multiple modes model should be used by communicators to facilitate the larger audience Furthermore, it should be used in such a way that they are harmonised and interrelate, contributing to the realisation of meaning throughout the text.
Role of Misconceptions and Miscommunications in Theatrical Characters: Analyzing Speech Acts in the Namibian Plays
Authors: Simasiku Virginia , Woldemariam Haileleul Zeleke 
Published: July 2023

The current study examines the misconceptions and misunderstandings in the speech acts of the characters within three Namibian plays, namely The Oracle of Cidino written by Francis Nyathi, Checkmate by Maria Amakali, and The Bride and Broom penned by David Stone Ndjavera. Furthermore, this research examines the ways, which depict instances where characters’ speech acts lead to misconceptions and misunderstandings in the selected plays. Thereby, delving into these aspects, this study sheds light on the complexities of communication within the selected theatrical works. Moreover, this study examines the impact of miscommunication in discussions, which can culminate differences in understanding of speech acts between the speaker and the listener. The listener, however, is prone to a variety of emotional reactions, which arise from misunderstandings in a conversation - including feelings of joy, humor, embarrassment, regret or self-assumption, and impression of the speaker's utterance. The results of the enquiry evinced that the location-based actions performed by the characters in the three selected plays included declarative, interrogative, and imperative resources that are extracted from three Namibian plays. This is achieved by adopting a discourse analysis research approach, identifying, and explaining speech acts based on five classes of speech acts. Additionally, the current study is established on five functions of speech acts and on the other hand, the declarative statements proliferate the fewest of times since they require specified circumstances to be performed.
Incidental vertebral fracture prediction using neuronal network-based automatic spine segmentation and volumetric bone mineral density extraction from routine clinical CT scans
Authors: Bodden Jannis , Dieckmeyer Michael , Sollmann Nico , Burian Egon , Rühling Sebastian , Löffler Maximilian T. , Sekuboyina Anjany , El Husseini Malek , Zimmer Claus , Kirschke Jan S. , Baum Thomas 
Published: July 2023

ObjectivesTo investigate vertebral osteoporotic fracture (VF) prediction by automatically extracted trabecular volumetric bone mineral density (vBMD) from routine CT, and to compare the model with fracture prevalence-based prediction models.MethodsThis single-center retrospective study included patients who underwent two thoraco-abdominal CT scans during clinical routine with an average inter-scan interval of 21.7 ± 13.1 months (range 5–52 months). Automatic spine segmentation and vBMD extraction was performed by a convolutional neural network framework (anduin.bonescreen.de). Mean vBMD was calculated for levels T5-8, T9-12, and L1-5. VFs were identified by an expert in spine imaging. Odds ratios (ORs) for prevalent and incident VFs were calculated for vBMD (per standard deviation decrease) at each level, for baseline VF prevalence (yes/no), and for baseline VF count (n) using logistic regression models, adjusted for age and sex. Models were compared using Akaike’s and Bayesian information criteria (AIC &amp; BIC).Results420 patients (mean age, 63 years ± 9, 276 males) were included in this study. 40 (25 female) had prevalent and 24 (13 female) had incident VFs. Individuals with lower vBMD at any spine level had higher odds for VFs (L1-5, prevalent VF: OR,95%-CI,p: 2.2, 1.4–3.5,p=0.001; incident VF: 3.5, 1.8–6.9,p&lt;0.001). In contrast, VF status (2.15, 0.72–6.43,p=0.170) and count (1.38, 0.89–2.12,p=0.147) performed worse in incident VF prediction. Information criteria revealed best fit for vBMD-based models (AIC vBMD=165.2; VF status=181.0; count=180.7).ConclusionsVF prediction based on automatically extracted vBMD from routine clinical MDCT outperforms prediction models based on VF status and count. These findings underline the importance of opportunistic quantitative osteoporosis screening in clinical routine MDCT data.