bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of fiberoptic intubation using i-gel® Plus and standard i-gel® : A Thiel-embalmed cadaveric study
Authors: Chaki Tomohiro , Tachibana Shunsuke , Kumita Sho , Sato Satoshi , Hirahata Tomoki , Ikeshima Yuta , Ohasaki Yuki , Yamakage Michiaki 
Published: July 2023

Abstract
Purpose
The supraglottic airway (SGA) is widely used. I-gel® Plus is a next-generation i-gel® with some improvements, including facilitation of fiberoptic tracheal intubation (FOI). To compare the performance of i-gel® Plus and standard i-gel® as a guide for FOI, a Thiel-embalmed cadaveric study was conducted.
Methods
Twenty-two anesthesiologists were enrolled as operators in Experiment 1. The i-gel® Plus and standard i-gel® were inserted into one cadaver, and FOI was performed through each SGA. In Experiment 2, fiberoptic views of the vocal cords in each SGA were assessed using nine cadavers. The primary outcome was time required for FOI. The secondary outcomes were the number of attempts and visual analog scale (VAS) score for difficulty in FOI. Moreover, time, number of attempts, VAS for difficulty of SGA insertion and gastric tube placement, and fiberoptic view of the vocal cords were evaluated as secondary outcomes.
Results
The time for FOI through i-gel® Plus was significantly shorter than that through standard i-gel® (median (IQR), i-gel® Plus: 30.5 (21.8–34.3) sec, vs standard i-gel®: 45.0 (28.0–89.0) sec; median of differences, 11.2 sec; 95% confidence interval, 7.1–41.3; P < 0.001). The number of attempts for successful FOI and the VAS for difficulty in the i-gel® Plus group were significantly lower than those in the standard i-gel® group. Moreover, i-gel® Plus required a significantly smaller upward angle of the fiberscope tip to obtain a 100% percentage of glottic opening score.
Conclusion
FOI can be performed more easily using i-gel® Plus than using standard i-gel®.
Upper Mantle deformation beneath the Northeastern part of Indian plate from Shear-wave splitting analysis
Authors: Kanaujia Jyotima , Surve G. 
Published: July 2023

Abstract
This study investigates seismic anisotropy in the northeastern region of the Indianplate, including the Eastern Himalayan front, Eastern Himalaya Syntaxis (EHS),Indo-Burmese subduction zone, Shillong plateau, Assam foredeep and Bengalbasin. Variations in azimuthal anisotropy are interpreted in terms of pre-existinglithospheric structures, mantle flow movement and dynamic lithospheric stresses.Analysis of shear-wave splitting (SWS) in the waveforms recorded at 64 stationsyielded 305 splitting (SKS, SKKS, and PKS phases) and 386 Null measurements.Results reveal an average delay time (δt) of 0.95 ± 0.32 s, indicating significantanisotropy. Modelling the backazimuthal dependence of the splitting parametersindicates two-layer anisotropy along the Eastern Himalaya, Shillong plateau, andsouth of the Dauki fault contiguous with the Indo-Burmese arc. Application ofthe spatial coherency technique localizes the depth of the anisotropic layers indifferent tectonic subdivisions. Stresses and lithospheric strain associated withAbsolute Plate Motion (APM) of India explain the deformation patterns gleanedfrom splitting measurements. A vertically coherent crust-mantle deformation isproposed at the Himalayan collision front, where east-west-oriented extensionalshear stresses result in north-south compressive strains. APM-related stressesforge anisotropy in the Assam foredeep region that shows a coupled crust-mantledeformation. East-west-oriented fast polarization directions (FPDs) beneath theShillong Plateau indicate localized mantle flow along the Dauki fault. The fastaxes of anisotropy in the Indo-Burmese subduction zone align parallel to the arc.These findings enhance the knowledge of mantle dynamics in the subduction andcontinent-continent collision zones.
Do emotion regulation strategies mediate the relationship of parental emotion socialization with adolescents’ and emerging adults’ psychological distress?
Authors: BUJOR LILIANA , TURLIUC MARIA NICOLETA , KLIMES-DOUGAN BONNIE 
Published: July 2023

AbstractA child’s ability to cope with stress is shaped by experiences in the parent-child relationship. The direct effect of a parent’s response to anger and happiness in childhood on adolescents’ and emerging adults’ psychological distress, and the indirect effect through the mediating role of emotion regulation strategies, specifically cognitive reappraisal and emotional suppression, were measured. To achieve our research aim we tested four parallel mediation models, using the bootstrapping method. A group of 497 participants, aged between 14 and 35 years (M = 18.62;SD = 3.32), 66% female (n = 332) and 34% male (n = 165), completed a questionnaire comprised of self-reporting measures. The results indicate direct effects between emotion socialization and distress for seven independent variables. The mother’s and father’s positive responses to anger and happiness are significant negative predictors of distress, the negative responses of both parents to happiness, and the mother’s negative response to anger, but not the father’s, are significant positive predictors of distress. The findings also provide support for the mediating role of expressive suppression and cognitive reappraisal for the mother’s positive response to both, anger and happiness, as well as for the mother’s negative response to the child’s expression of happiness. None of father’s responses, positive or negative, in relation to anger or happiness, are mediated by emotion regulation strategies in relation to distress. The findings have some important theoretical and clinical implications for distressed adolescents and emerging adults.
Consensus on relevant psychosocial interventions applied in health institutions to prevent psychological violence at work: Delphi method
Authors: Tueros Luis Fidel Abregú , Bravo-Esqu Cinthia Jannete , Abregú-Arroyo Sheyla Karol , Santos-Rosa Roger Dos , Manzano José Luis Galve 
Published: July 2023

Abstract
Objective
Studies on workplace violence (WPV) in Latin America have focused on incidence values. In contrast, studies on preventive interventions (PIs) in the health sector are very limited. Our objective was to determine to what extent there is consensus on the most relevant characteristics of the psychosocial interventions applied in the prevention of WPV in health institutions in Peru. To that end, health professionals with knowledge and experience in WPV at the national level were recruited, and the Delphi consensus technique was applied.
Results
The consensus study was developed in four stages that included three phases of Delphi consultation. In the third consultation phase, 428 experts participated in 25 analysis groups from 66 health institutions in the country. A total of 70.3% of the participants were women, and 27.6% of the participants worked in nursing and emergency services. After the Delphi consensus analysis, we obtained a list of 10 hierarchical psychosocial interventions to prevent WPV in the country. Most notable were interventions based on the prior resolution of interprofessional conflicts, on the visibility of incidents to generate an inverse effect and on experiential training to improve assertive and empathic communication skills.
Enriched environment promotes neuroplasticity by regulating the ALK5/Smad2/3/Gadd45β signaling pathway in rats with cerebral ischemia/reperfusion injury
Authors: Liu Gang , Xie Chenchen , Li Jiani , Jiang Xia , Tang Hao , Li Changqing , Zhang Keming 
Published: July 2023

AbstractBackground/AimsEnriched environment (EE) has been shown to modulate neuroplasticity in neurodegenerative diseases, but its role and mechanisms in ischemic stroke remain unclear. Our previous findings revealed that EE can promote cerebral activin receptor-like kinase 5 (ALK5) expression after cerebral ischemia/reperfusion (I/R). It was found that ALK5 might play a role in neuroplasticity through the modulation of Smad2/3/Growth Arrest DNA Damage 45 β (Gadd45β). Therefore, the present study aimed to explore the role of EE on neuroplasticity after cerebral ischemia/reperfusion and its mechanisms.MethodsThe middle cerebral artery occlusion/reperfusion (MCAO/R) method was employed to establish a rat model of cerebral ischemia/reperfusion injury. The role of ALK5 was determined by intracerebral stereotactic injection of adeno-associated virus (AAV) to inhibit the expression of ALK5. The respective effects of EE treatment with or without ALK5 knockdown on ALK5/Smad2/3/Gadd45β expression, infarct volume, newborn neurons, dendritic complexity and regenerated nerve fibers in rats were observed.ResultsCerebral I/R injury induced an increase in ALK5 expression, Smad2/3 phosphorylation ratio, and Gadd45β expression for up to 14 days. EE treatment further enhanced the expression of these molecules, which was reversed by ALK5 knockdown. The protective effect of EE treatment on brain infarct volume, neurological function, newborn neurons, dendritic complexity, and nerve fiber regeneration following I/R injury were counteracted by the AAV-ALK5-induced knockdown of ALK5.ConclusionEE treatment can enhance neuroplasticity following cerebral ischemia/reperfusion injury, which was mediated by the regulation of ALK5/Smad2/3/Gadd45β signaling pathway.
Evaluation of factors predicting the benefit from systemic oncological treatment for severely ill hospitalized patients: A retrospective study
Authors: Neves Milena Brachmans Mascarenhas , Neves Yuri Costa Sarno , Bomonetto Juliana Vieira Biason , Matos Priscila Prais Carneiro , Giglio Auro Del , Cubero Daniel de Iracema Gomes 
Published: July 2023

Abstract
Background
Patients with cancer in the disease’s end-stage with poor performance represent a challenging clinical scenario, as they have high chance of a fatal outcome due to clinical conditions, oncological emergencies, and/or metastatic disease. This study examines the factors predicting the potential benefit of “urgent” chemotherapy during hospitalization in this setting, thus addressing a research gap.
Methods
This retrospective observational study was conducted in the largest cancer center in the outskirts of São Paulo. It identified factors predicting the benefit from antineoplastic treatment in severe in-hospital patients admitted during 2019–2020, considering post-chemotherapy survival time as the main dependent variable. Data were retrieved from medical records. All patients aged ≥ 18 years, with an ECOG-PS score ≥ 2, and undergoing non-elective systemic cancer treatment were included.
Results
This study evaluated 204 records, of which 89 were included in the final analysis. A statistically significant association with the worse outcome (death within 30 days of chemotherapy) was found with higher ECOG performance status; chemotherapy dose reduction; lower values of serum albumin, hemoglobin, and creatinine clearance; and higher values of leukocytes, neutrophils, direct bilirubin, urea, and C-reactive protein. In the multivariate analysis, only albumin remained statistically associated with the outcome (hazard ratio = 0.35; confidence interval: 0.14, 0.90; p = 0.034).
Conclusions
Serum albumin and other clinical and laboratory variables might be associated with early post-treatment deaths in patients with cancer. The study data might help guide the decision to administer systemic treatment in this scenario and manage critically ill patients. This study adds to our knowledge of the factors predicting the objective benefits from “heroic” or “urgent” chemotherapy for hospitalized and severely ill patients with cancer.
Analysis and validation of genes co-expressed in Crohn's disease and cervical cancer based on GEO database.
Authors: ZHANG Le , Zou Jing , Wang Zhen , Liu Hongru , Jiang Bei , Liang Yi , ZHANG YuZhe 
Published: July 2023

Abstract
Background
In recent years, many studies have shown that Crohn's disease (CD) can increase the incidence of cervical cancer in women. However, the mechanism of the association is unclear, and this study aimed to investigate further the mechanisms underlying the joint development of both diseases.
Methods
Gene expression profiles of Crohn's disease (GSE95095) and cervical cancer (GSE63514) were downloaded from the GEO database. Differentially expressed genes (DEGs) in the experimental group and control group of Crohn's disease and cervical cancer were searched for, as well as co-expressed genes in the two conditions. These co-expressed genes were then subjected to functional annotation, protein-protein interaction (PPI) network and module construction, screening and co-expression analysis of key genes, and prediction and validation of transcription factors that exert regulatory effects on the corresponding key genes.
Results
A total of 63 co-expressed genes were screened from the differential genes of the two disease groups: 17 up-regulated and 46 down-regulated genes. Functional analysis revealed that hormone metabolic processes, steroid hormone synthesis processes and angiogenesis, play a crucial role in both diseases. In addition, 15 important core genes were screened. We used core genes that were upregulated in both diseases. The core genes upregulated in both conditions: AKR1B1, CHI3L1, CXCR4 and DUSP2, were used to construct risk models for predicting disease progression. Finally, it is expected that transcription factors such as MYC, VHL and SP1 may play a regulatory role on core genes, with the regulation of CXCR4 by the transcription factor MYC deserving an in-depth study. Combining the extent scores and high expression levels of both diseases, CXCR4 is considered the most risky gene and is expected to be a biomarker for both diseases. Finally, CXCR4 expression in cervical cancer was verified using immunohistochemistry and protein immunoblotting assays.
Conclusion
This study has provided initial insights into the common pathogenesis of Crohn's disease and cervical cancer and the potential co-expression of key genes. These common pathways and key gene mechanisms require further investigation and can provide a crucial reference for early clinical diagnosis and treatment.
A modification in Weibull parameters to achieve a more accurate probability distribution function in fatigue applications
Authors: Fakoor Hamed , Kaklar Javad Alizadeh 
Published: July 2023

Abstract
Risk evaluation for fatigue failure of the engineering components is an important aspect of the engineering design. This study presents a probabilistic model for calculating Weibull distribution parameters to reduce the effect of percentage discretization error of experimental fatigue life and R-S-N curves for three reliability levels. The results show some error reduction in the Kolmogorov-Smirnov test and R-square values. Also, the Basquin model is used for different reliability levels with the same error order. The coefficient of variation for fatigue life increases at higher stress levels and has a linear relation with stress level for a high-cycle fatigue regime.
Theoretical and experimental study of tool wear using active backup force for drilling composite materials
Authors: Liao Shao-Sen , Tsao chung-chen 
Published: July 2023

Abstract
The advent of composite materials has allowed for the state-of-the-art fabrication of structural parts with delamination-free holes. These are widely used polymers in aerospace, military and biomedical devices. Fabricating a delamination-free hole using a traditional twist drill is fast and cost-effective but the surface roughness depends on the drilling parameters, the tool geometry and the tool material. However, tool wear is inevitable when machining composite materials. It reduces the service life of the tool and affects the surface quality and the dimensional accuracy of structural parts. A mechanical and energy analysis is used to develop a mathematical model for the critical thrust force to correlate tool wear and the associated active backup force for drilling composite materials. The theoretical analysis and experimental results show that delamination due to worn twist drills is mitigated by using an active backup force. The developed model is extended to determine the effect of tool wear and an active backup force on the thrust force for future drill bits.
Penile Oleogranuloma: surgical management in Kazakhstan
Authors: Suleiman Makhmud , Mustafa Aidana , Ainayev Yernur , Urazova Saltanat , Garkalov Konstantin , Muldayeva Gulmira , Mustafin Adil , Turebayev Dulat , Zhanbyrbekuly Ulanbek , Gudeloglu Ahmet 
Published: July 2023

Abstract
Oleogranuloma of the penis is a complex set of pathological processes caused by the injection of a foreign substance (gel, balls, rods, etc.) into the penis with the purpose of penile augmentation. We investigated the relevance of this problem to Kazakhstan and described our experience in managing the complications. We analyzed data on 18 patients with penile self-injections admitted to the hospitals of Astana city, Kazakhstan during an 11-year period. The mean age of patients at admittance was 37.4 years. The most common substance of injection was vaseline (n=16, 88%). The mean interval between the time of injection and the first presentation to the hospital was 10.8 years. Complications included necrosis (n=13, 72.2%), pain or swelling (n=6, 33.3%), cosmetic dissatisfaction (n=5, 27.8%). All patients received surgical treatment (n=18, 100%): primary incision was performed for one half of patients (9, n=50%), while another half of patients underwent the Reich’s surgery (9, n=50%). Our data suggest that the prevalence of oleogranuloma in Kazakhstan is higher than it was previously admitted. The findings of this study should raise the awareness about the complications of penile self-injections among high-risk groups (e. g. prisoners) and physicians for prevention and early diagnosis, respectively.
Infected Urachal Cyst with Urethral Stricture Presenting as Acute Appendicitis: Case Report
Authors: Aggarwal Swati , Ohri Gunvi , Anand Rohit , Anand Madhur 
Published: July 2023

Abstract
Introduction: Urachal anomalies are rare disorders of the urogenital tract, more commonly found in males, and sometimes they may masquerade as other diseases. We present a case of urachal cyst with urethral stricture which presented as acute appendicitis.
Case presentation: A 22-year-old patient presented to our emergency department in shock, following a one-week history of pain in the lower right abdomen. The patient was initially diagnosed with acute appendicitis based on clinical examination, and a urology consultation was requested due to the inability to catheterize the patient. The patient also reported a history of dysuria and straining, with unsuccessful attempts at catheterization. Ultrasonography revealed the presence of free fluid in the peritoneum and grade III hydroureteronephrosis. During exploratory laparotomy, we discovered a urachal cyst that had no connection with the bladder. The urachal cyst was excised after performing a suprapubic cystostomy. Following conservative surgery for pus drainage and excision of the urachal cyst, further management in the form of urethroplasty was performed to address the urethral stricture.
Conclusions: Urachal abnormalities are rare causes of abdominal pain. Obtaining a detailed patient history and maintaining a high index of suspicion is crucial for improving patient outcomes
Association between psychological distress and possible, probable, and definite sleep bruxism - a comparison of approved diagnostic procedures
Authors: Walentek Nicole Pascale , Schäfer Ralf , Bergmann Nora , Franken Michael , Ommerborn Michelle Alicia 
Published: July 2023

Abstract
The relationship between sleep bruxism (SB) and psychological distress has been investigated in numerous studies. In general it seems to be problematic that SB is determined with different diagnostic procedures, especially when some of them might not be very valid. The aim of this study was to directly compare the association between psychological distress and SB diagnosed by different accepted methods. In a sample of N = 45 subjects, possible, probable, and definite SB was determined. Psychological distress was measured using the global severity index (GSI) of the Symptom-Checklist-90-Standard. Statistical analysis included group comparisons and correlation analyses. The GSI did not differ significantly between subjects with and without SB, regardless of the underlying diagnostic classification. However, a deeper analysis of specific variables reveals that subjective and clinical SB-specific criteria have a higher correlation with psychological distress. Variables of instrumental methods such as the SB index of the polysomnographic (PSG) examination show almost no correlation with psychological distress. Possibly, non-instrumental methods (self-assessment and clinical examination) capture more psychological components related to SB, such as somatization tendencies. Original SB activity like grinding and muscle contraction of instrumental methods (polysomnography and new diagnostic sheet) shows no correlation with psychological distress.
Effects of glycemic indicators on early neurological outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis
Authors: Duan Zuowei , Li Zhining , Zhang Cuicui , Zhang Jun , Hu Ting , Wei Xiu’e , Rong Liangqun , Zhai Yujia , Liu Haiyan 
Published: July 2023

Abstract
Background: To investigate the predictive value of the glycemic indicators for early neurological outcomes (ENO) in patients with acute ischemic stroke (AIS) treated with intravenous thrombolysis (IVT).
Methods: The prospective collected database of AIS undergoing IVT at the Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University between January 2017 and Jun 2022 was retrospectively reviewed. ENO includes early neurological improvement (ENI) and early neurological deterioration (END), which was defined as a decrease or an increase in NIHSS score between baseline and 24 hours after IVT. The associations between glycemic indicators (including admission hyperglycemia [AH], fasting blood glucose [FBG] and Stress hyperglycemia ratio [SHR]) and ENO were analyzed in all patients and subgroups stratified by diabetes mellitus (DM).
Results: A total of 819 patients with AIS treated with IVT were finally included. Of which, AH was found in 329 patients (40.2%). Compared with patients without AH, patients with AH were more likely to have a higher prevalence of DM (P﹤0.001) and hypertension (P=0.031), and presented with higher admission NIHSS score(P﹤0.001). During the first 24 h after IVT, END was observed in 208 patients (25.4%), and ENI was observed in 156 patients (19.0%). Compared to neither ENI nor END, END was independently associated with AH (OR=1.744, 95%CI: 1.236-2.463, P=0.002), FBG(OR=1.077, 95%CI: 1.017-1.141, P=0.012) and SHR(OR=1.600, 95%CI: 1.025-2.495, P=0.038). While none of the glycemic indicators was unrelated to the presence of ENI. Subgroup analysis indicated that AH (OR­DM=1.954, 95%CI: 1.061-3.601, P=0.032; ORNon-DM=1.602, 95CI: 1.027-2.499, P=0.038), FBG (OR­DM=1.105, 95%CI: 1.008-1.212, P=0.034; ORNon-DM=1.111, 95CI: 1.017-1.213, P=0.020), SHR(OR­DM=3.126, 95%CI: 1.315-7.429, P=0.010; ORNon-DM=2.200, 95CI: 1.200-4.034, P=0.011) were all independently related to END both in patients with DM and those without DM. Nevertheless, none of the glycemic indicators was found associated with ENI in patients with DM and those without DM.
Conclusions: Our study demonstrated that AH, FBG and SHR in stroke patients treated with IVT were associated with the presence of END rather ENI during the first 24 hours after admission.