bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical validation of quantitative SARS-CoV-2 subgenomic and viral load laboratory developed tests conducted on the Panther Fusion® (Hologic) with preliminary application to clinical samples
Authors: Lakhal-Naouar Ines , Hack Holly R. , Moradel Edgar , Jarra Amie , Grove Hannah L. , Ismael Rani M. , Padilla Steven , Coleman Dante , Ouellette Jason , Darden Janice , Storme Casey , Peachman Kristina K. , Hall Tara L. , Huhtanen Mark E. , Scott Paul T. , Hakre Shilpa , Jagodzinski Linda L. , Peel Sheila A. 
Published: June 2023

Objective
Validate the performance characteristics of two analyte specific, laboratory developed tests (LDTs) for the quantification of SARS-CoV-2 subgenomic RNA (sgRNA) and viral load on the Hologic Panther Fusion® using the Open Access functionality.

Methods
Custom-designed primers/probe sets targeting the SARS-CoV-2 Envelope gene (E) and subgenomic E were optimized. A 20-day performance validation following laboratory developed test requirements was conducted to assess assay precision, accuracy, analytical sensitivity/specificity, lower limit of detection and reportable range.

Results
Quantitative SARS-CoV-2 sgRNA (LDT-Quant sgRNA) assay, which measures intermediates of replication, and viral load (LDT-Quant VLCoV) assay demonstrated acceptable performance. Both assays were linear with an R2 and slope equal to 0.99 and 1.00, respectively. Assay precision was evaluated between 4–6 Log10 with a maximum CV of 2.6% and 2.5% for LDT-Quant sgRNA and LDT-Quant VLCoV respectively. Using negative or positive SARS-CoV-2 human nasopharyngeal swab samples, both assays were accurate (kappa coefficient of 1.00 and 0.92). Common respiratory flora and other viral pathogens were not detected and did not interfere with the detection or quantification by either assay. Based on 95% detection, the assay LLODs were 729 and 1206 Copies/mL for the sgRNA and VL load LDTs, respectively.

Conclusion
The LDT-Quant sgRNA and LDT-Quant VLCoV demonstrated good analytical performance. These assays could be further investigated as alternative monitoring assays for viral replication; and thus, medical management in clinical settings which could inform isolation/quarantine requirements.
Association between caffeine consumption and bone mineral density in children and adolescent: Observational and Mendelian randomization study
Authors: Cui Aiyong , Xiao Peilun , He Jing , Fan Zhiqiang , Xie Mengli , Chen Long , Zhuang Yan , Wang Hu 
Published: June 2023

Background
Coffee is the most commonly consumed beverage among children and adolescences. Caffeine was demonstrated to be associated with bone metabolism. However, the relationship between caffeine intake and BMD in children and adolescents remains unclear. This study aimed to identified relationship between caffeine consumption and bone mineral density (BMD) in children and adolescents.

Methods
Based on National Health and Nutrition Examination Survey (NHANES), we conducted an epidemiological cross-section study to measure the relationship between caffeine consumption and BMD in children and adolescents by multivariate linear regression models. Then, five methods of Mendelian randomization (MR) analyses were performed to estimate their causal relationship between coffee and caffeine intake and BMD in children and adolescents. MR-Egger and inverse-variance weighted (IVW) were used to evaluate the heterogeneity effect of instrumental variables (IVs).

Results
In epidemiological studies, individuals with the highest quartile of caffeine intake do not have a significant change in femur neck BMD (β = 0.0016, 95% CI: -0.0096, 0.0129, P = 0.7747), total femur BMD (β = 0.0019, P = 0.7552), and total spine BMD (β = 0.0081, P = 0.1945) compared with the lowest quartile. In MR analysis, the IVW-random effect indicates no causal relationship between coffee consumption and TB- BMD (β = 0.0034, P = 0.0910). Other methods of MR analyses and sensitivity analysis reveals consistent findings. Similarly, the fixed-effects IVW method shows no causal association between caffeine intake and TB-BMD in children and adolescents (β = 0.0202, P = 0.7828).

Conclusions
Our study does not support a causal relationship between caffeine consumption and BMD in children and adolescents. However, more studies are needed to verify our findings, such as its underlying molecular mechanisms and the long-term impact of early caffeine exposure at a younger age.
Neurodevelopmental outcomes in individuals with VACTERL association. A population-based cohort study
Authors: Kassa Ann-Marie , Lilja Helene Engstrand 
Published: June 2023

Background
Studies on neurodevelopmental outcomes in individuals with congenital anomalies who undergo neonatal surgery are scarce and have reported contradictory findings based on small study groups. The congenital condition VACTERL association includes at least three malformations: vertebral anomalies, anorectal malformations, cardiac defects, tracheoesophageal fistula with or without esophageal atresia, renal anomalies and limb deformities. Most of these patients undergo surgery during their first days of life. Neurodevelopmental disorders include a broad group of disabilities involving some form of disruption to brain development. Attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASD) and intellectual disability (ID) are diagnoses included in this group. The aim of the study was to investigate the risk of ADHD, ASD and ID in a cohort of individuals with VACTERL association.

Method
Data was obtained from four Swedish national health registers and analyzed using the Cox proportional hazards model. Patients born 1973–2018 in Sweden with the diagnosis of VACTERL association were included in the study. For each case five healthy controls matched for sex, gestational age at birth, birth year and birth county were obtained.

Results
The study included 136 individuals with VACTERL association and 680 controls. Individuals with VACTERL had significantly higher risk of ADHD, ASD and ID than the controls; 2.25 (95% CI, 1.03–4.91), 5.15 (95% CI, 1.93–13.72) and 8.13 (95% CI, 2.66–24.87) times respectively.

Conclusions
A higher risk of ADHD, ASD and ID was found among individuals with VACTERL association compared to controls. These results are of importance to caregivers and to professionals participating in follow ups of these patients in providing early diagnosis and support, aiming to optimize the quality of life of these patients.
Anforderungen an Führungskräfte bei der Qualifizierung und Kompetenzentwicklung
Authors: Peifer Yannick , Terstegen Sebastian 
Published: June 2023

Abstract
Künstliche Intelligenz (KI) verändert die Arbeitswelt und führt zu einer dynamischen Neugestaltung der Arbeitsteilung zwischen Mensch und Technik in Unternehmen. Durch die Automatisierung auch kognitiv anspruchsvoller Tätigkeiten können KI-Systeme beispielsweise Führungskräfte bei der Ausübung ihrer Aufgaben unterstützen und teilweise administrative Koordinations- und Kontrollaufgaben von Beschäftigten übernehmen. Für die Neugestaltung der Arbeitssysteme in den Unternehmen bedarf es zum einen geeigneter Instrumente. Zum anderen ist ein gut strukturiertes Change-Management wichtig, das sich an der menschzentrierten Arbeitsgestaltung orientiert und KI-spezifische Gestaltungskriterien berücksichtigt.
An ATG12‐ATG5‐TECPR1 E3‐like complex regulates unconventional LC3 lipidation at damaged lysosomes
Authors: Corkery Dale P , Castro‐Gonzalez Sergio , Knyazeva Anastasia , Herzog Laura K , Wu Yao‐Wen 
Published: June 2023

AbstractLysosomal membrane damage represents a threat to cell viability. As such, cells have evolved sophisticated mechanisms to maintain lysosomal integrity. Small membrane lesions are detected and repaired by the endosomal sorting complex required for transport (ESCRT) machinery while more extensively damaged lysosomes are cleared by a galectin‐dependent selective macroautophagic pathway (lysophagy). In this study, we identify a novel role for the autophagosome‐lysosome tethering factor, TECPR1, in lysosomal membrane repair. Lysosomal damage promotes TECPR1 recruitment to damaged membranes via its N‐terminal dysferlin domain. This recruitment occurs upstream of galectin and precedes the induction of lysophagy. At the damaged membrane, TECPR1 forms an alternative E3‐like conjugation complex with the ATG12‐ATG5 conjugate to regulate ATG16L1‐independent unconventional LC3 lipidation. Abolishment of LC3 lipidation via ATG16L1/TECPR1 double knockout impairs lysosomal recovery following damage.
Borges, un tahúr en la corte del rey Assurbanipal
Authors: Ingelmo Salomé Guadalupe 
Published: June 2023

La biblioteca de Babel y La lotería de Babilonia, quizá entre los títulos más recordados de Borges, son sólo dos testimonios del interés que el autor nutrió hacia el mundo próximo-oriental. No se trata de un hecho puntual o meramente anecdótico; no son pocas las menciones o alusiones a la cultura mesopotámica no sólo en sus relatos, sino también en sus poemas y ensayos. Y si hacemos extensivo el concepto de mesopotámico al mundo de la periferia próximo-oriental, en concreto al antiguo Israel o incluso a la antigua Arabia, las referencias se multiplican vertiginosamente. El objeto del presente artículo será indagar sobre los motivos que llevaron al erudito Borges, al escritor de saber enciclopédico, a sentirse atraído por la antigua Mesopotamia. Así como esclarecer el significado o los significados que este ámbito espacio-temporal adquiere en su obra literaria, en particular en su producción narrativa.Palabras clave: La biblioteca de Babel, La lotería de Babilonia, Los dos reyes y los dos laberintos, Tlön, Uqbar, Orbis Tertius, literatura fantástica inglesa, antiguo Israel, antigua Arabia, Uqbar, The Anglo-American Cyclopaedia, Poema de Gilgamesh, Biblia, Las mil y una noches, Cábala, laberinto, espejo, Xul Solar, Chestserton, Leonard Woolley, Ur of the Chaldees, biblioteca de Assurbanipal, La Torre de Babel, Pieter Brueghel El Viejo, paradigma del caos, símbolo de la soberbia, despotismo oriental, regímenes dictatoriales del siglo XX, tablillas psefománticas, juego de dados, funcionario epónimo paleo-asirio. AbstractThe Library of Babel and The Lottery in Babylon, perhaps among the most popular titles written by Borges, are just two traces of interest that the author developed for the Near East. It is not a single event or a mere anecdote, there is no shortage of references or allusions to the Mesopotamian culture not only in his short stories, but also in his poems and essays. And if we include in the concept of “Mesopotamian” also near eastern periphery, specifically ancient Israel or even ancient Arabia, references increase in a dizzying fashion. The purpose of this article will be to explore the reasons that led the erudite Borges, the writer of encyclopedic knowledge, to be attracted to ancient Mesopotamia. As well as clarify the meaning or meanings that this spatiotemporal framework acquires in his writing, especially in his narrative production.Keywords: The Library of Babel, The Lottery in Babylon, The Two Kings and their Two Labyrinths, Tlön, Uqbar, Orbis Tertius, American and British fantastic and mystery literature, ancient Israel, ancient Arabia, Uqbar, The Anglo-American Cyclopaedia, Epic of Gilgamesh, Bible, One Thousand and One Nights, Kabbalah, labyrinth, mirror, Xul Solar, Chesterton, Leonard Woolley, Ur of the Chaldees, library of Ashurbanipal, The Tower of Babel, Pieter Brueghel the Elder, 20th century dictatorial regimes, psephomantic tablets, dice game, paleo-assyrian eponymous official.
The magic duel from Sumer to Grail: Considerations on a Study by A. Coomaraswamy
Authors: Mander Pietro 
Published: June 2023

In 1944 Ananda Coomaraswamy published an essay on the parallels between the plot of Sir Gawain and the Green Knight, a Medieval English poem that forms part of the cycle of The Knights of the Round Table, and the mythological Hindu tale on the fight between the god Indra and Namuci. By means of this essay Coomaraswamy expounded his manifesto of Philosophia perennis, and referred to many mythologies of other cultures to illustrate the metaphysical theme of the One and the Many, the creation of Time and Space, and the Reintegration into the One. At that time the Sumerian poem Lugal-e ud melambi nir?al was not well known. Now it is not only possible to integrate the documentation Coomaraswamy put forward with this poem and other Mesopotamian myths, but also to include Mesopotamian religious thought in the general pattern he outlined.Keywords: Coomaraswamy, Sir Gawain and the Green Knight, Indra and Namuci, Lugal-e, En?ma eliš, Ninurta,Marduk, Tigris, Water of life, Cosmogony, One and Many, Philosophia Perennis, Border of the world, cosmicorder, Splitting of heaven from earth, Hieros gamos, soul, Reintegration, Phenomenological method. RiassuntoNel 1944 Ananda Coomaraswamy pubblicò un saggio sui paralleli tra la trama del poema inglese medievale Sir Gawain e il Cavaliere Verde, che fa parte del ciclo dei Cavalieri della tavola Rotonda, e il mito indiano sullo scontro tra il dio Indra e Namuci. Con questo saggio Coomaraswamy rese pubblico il suo manifestó di Philosophia perennis, e riferì su molte mitologie di altre culture, per illustrare il tema metafisico dell'Unoe del Molteplice, la creazione di Tempo e Spazio e la Reintegrazione nell' Uno. A quel tempo, il poema sumerico Lugal-e ud melambi nir?al non era ben conosciuto. Ora non solo è possibile integrare la documentazione addotta da Coomaraswamy con questo poema ed altri miti mesopotamici, ma anche includere il pensiero religioso mesopotamico nello schema generale che egli delineò.Parole chiave: Uno e Molteplice, Ordine cosmico, Confine del mondo, Separazione di cielo e terra, Anima, Reintegrazione, Metodo fenomenologico, Acqua di vita.
El libro de "Viaje a Italia" en España: las cartas familiares de Juan Andrés
Authors: Arbillaga Guerrero Idoia 
Published: June 2023

El presente estudio ofrece una aproximación a la tradición literaria del viaje a Italia, viaje cultural por excelencia, particularmente acerca del género literario resultante de dicha tradición y sus resonancias en España. Asimismo se ofrece un más pormenorizado análisis de la mejor muestra española del género, y una de las más importantes de occidente, las cartas familiares de Juan Andrés.Palabras clave: Literatura de viaje, crítica literaria, estética, literatura comparada, viaje a Italia, teoría del género de viaje. AbstractThe book 'Journey to Italy' in Spain: Family Letters by Juan Andrés: This study provides an approach to the literary tradition of the journey to Italy, the cultural trip par excellence, especially about the literary genre which results from that tradition and its resonances in Spain. Furthermore, the study provides a detailed analysis of the best Spanish example of this genre, and one of the most important in Western countries: Family Letters by Juan Andrés.Keywords: Travel writing, travel literature, literary criticism, aesthetics, comparative literature, trip/journey to Italy, travel genre theory / theory of travel literature genre.
An Appraisal of Ekalte 11 (MBQ-T 65): 34 from Tall Munb?qa (Syria)
Authors: Oliva J. , Torrecilla E. 
Published: June 2023

El texto acadio de Tell Mumb?qa-Ekalte (Siria): Ek 11 (MBQ-T 65) contiene en su línea 34 un pasaje sumamente raro que todavía permanece sin traducción coherente desde que se publicó este archivo. Aunque este documento emplea una fraseología legal similar a la de otros textos de Ekalte, muestra una diferencia interesante en la utilización del logograma Ì.LÁ.E y su cláusula de penalización. Éstos –logograma y cláusula de penalización– se expresan mediante un patrón desconocido. El claro contexto económico del pasaje asegura, en cualquier caso, que Ì.LÁ.E no se usa en este texto en su posición normal en la apodosis, sino claramente en la prótasis. El objetivo de esta contribución es investigar este problemático contexto del acadio de Ekalte y ofrecer nuevas perspectivas de interpretación.Palabras clave: Acadio, Ekalte AbstractThe Akkadian text from Tall Munb?qa-Ekalte (Syria): Ek 11 (MBQ-T 65) contains on its line 34 a rather bizarre passage which still remains without a coherent translation since the Ekalte texts were published. Although this document uses a similar legal phraseology generally employed in the Ekalte documents, it shows an interesting difference in using the logogram Ì.LÁ.E and the penalty clause. These are expressed through a different clause pattern. The clear economic nature of the context assures in any case that Ì.LÁ.Eis not used in this text in its normal position in the apodosis formula, but in the protasis. The aim of the present paper is to investigate this problematic context and to offer some new perspectives on trying to understand this difficult passage in the Akkadian of Ekalte.Keyworeds: Akkadian, Ekalte
Sealing pots in Upper Mesopotamia in the late third millennium
Authors: Gallego López Alejandro 
Published: June 2023

A pesar de que la utilización de sellos está bien documentada en Mesopotamia gracias al hallazgo de un elevado número de cilindro-sellos, cretullae y bullae, si centramos el espectro a las improntas de cilindrosellos en cerámica éstos merman notablemente. A lo largo de las últimas dos décadas la arqueología próximo-oriental ha intensificado su interés en este tipo de improntas, muy especialmente en la cuenca del Khabur, donde yacimientos como Tell Beydar, Tell Arbid y Tell Brak han proporcionado valiosas muestras de la manera en que dichos instrumentos administrativos eran utilizados. El análisis de la tipología y contexto arqueológico de la cerámica y su correspondiente sello puede ayudarnos a comprender de una manera más amplia las estructuras administrativas en la Alta Mesopotamia a fines del Tercer Milenio a.C. y a valorar si la influencia del Sur de Mesopotamia era reconocible en las formas y estilos.Palabras clave: Cilindro-sello, cerámica, sello, Khabur. AbstractAlthough the practice of sealing is well attested in Mesopotamia due to the numerous finds of cylinder-seals, clay sealings and bullae, when considering sealing impressions on pots the scope of this study dwindles remarkably. Within the last two decades Near Eastern archaeology has paid much more interest to this kind of impressions, specifically in the area of the Khabur basin, where archaeological sites such as Tell Beydar, Tell Arbid and Tell Brak have provided us with good samples of how this administrative device was used. The analysis of typology and the context of the pottery and its respective sealing will help us better understand the administrative schemes in Upper Mesopotamia during the Late Third Millennium, and whether Southern Mesopotamia influence is visible in local styles and shapes.Keywords: Cylinder-seal, pottery, sealing, Khabur.
Estructuras hidráulicas hititas
Authors: Arroyo Ana 
Published: June 2023

En prácticamente todas las memorias de excavación de asentamientos hititas (Anatolia, II mil. a.C.) se documenta la presencia de estructuras relacionadas con el acopio, distribución y evacuación de agua. Parte de la información textual llegada hasta nosotros indica la importancia otorgada al mantenimiento de estas estructuras como elementos fundamentales de los recintos de población. En estas páginas se pretende ofrecer una visión general de los tipos de estructuras hidráulicas documentadas para este período y en este ámbito geográfico, cuyas particularidades condicionan estos mismos tipos y los diferencian, en ocasiones, de los ejemplos documentados en otros ámbitos próximo-orientales.Palabras clave: Anatolia, hititas, gestión del agua, conducciones, depósitos, fuentes, presas, potabilidad. Abstract:Structures connected with water management, that is, structures that allow gathering, distribution and discharge of water, have been documented in almost every Hittite site (Anatolia, 2nd mill. BC.) Some Hittite texts give us insigths into the significance of maintaining such structures, essential constituents of every settlement. On the following pages would be provided a general vision of the different types of these structures documented for both those period and landscape, whose particularities condition these very types and, occasionally, make them differ from another Ancient Near Eastern examples.Keywords: Anatolia, Hittites, water-management, water pipe, water tank, fountain, dam, potability.
La fundación de la ciudad de Gadir y su primer santuario urbano de Astarté-Afrodita
Authors: Mederos Martín Alfredo 
Published: June 2023

La fundación de Gadir fue consecuencia de las pobres condiciones portuarias del santuario de Melqart enSancti Petri, lo que exigió pronto un buen fondeadero. La ciudad pudo ser fundada por sirio-fenicios de Arwad, lo que explicaría la presencia de los santuarios de Astarté-Afrodita y el altar de Kronos, pero la conquista asiria de Arwad por Tiglath-Pileser I, en el siglo XI a.C., facilitó la posterior hegemonía tiria enel siglo X a.C. El santuario de Astarté-Afrodita ofreció protección a la navegación, oráculos y prostitución sagrada a marinos y comerciantes y creó un espacio sacro para las mujeres en la nueva colonia. A partir del reinado Hiram I, a mediados del siglo X a.C., se empezó a celebrar el “despertar de Hércules”, un hiero gamos o matrimonio sagrado del rey o sacerdote con la diosa Astarté o su sacerdotisa, entre el momento de la muerte del dios Melqart en la pira funeraria hasta su égersis o resurrección en la mañana del tercer día. Esta escena fue también representada en las puertas del Herakleion gaditano, que creemostenía 20 escenas representadas, y no 10 como menciona Silio Itálico. Esta propuesta explica por primera vez que en la descripción sólo figuraban 6 de los trabajos más conocidos de Herakles y la supuesta ausencia de trabajos desarrollados en Occidente como el robo de los ganados de Gerión y el robo de las manzanas de las Hespérides por Herakles.Palabras clave: Fundación de Gadir, santuarios de Melqart y Astarté, Arwad, trabajos de Heracles. AbstractThe foundation of Gadir was the result of poor harbour conditions of the sanctuary of Melqart in Sancti Petri, requiring good anchorage soon. The city may have been founded by Syrian-Phoenician Arwad, which would explain the presence of the sanctuary of Astarte-Aphrodite and the altar of Kronos, but the Assyrian conquest of Arwad by Tiglath-Pileser I, in the eleventh century BC, facilitated the Tyrian hegemony in the tenth century BC. The sanctuary of Astarte-Aphrodite offered nautical protection, oracles and sacred prostitution to sailors and traders and created a sacred space for women in the new colony. From Hiram I reign in the mid-tenth century BC, began to celebrate the “awakening of Hercules”, a hiero gamos or sacred marriage of the king or the priest and the goddess Astarte or her priestess, between the time of death god Melqart on the funeral pyre until his egersis or resurrection on the third morning. This scene was also represented at the doors of the Herakleion of Gadir, which we think it had 20 scenes depicted, not 10 as mentioned by Silius Italicus. This proposal explains for the first time that the description contained only 6 of the best known labours of Heracles and the alleged lack of some works developed in the West as the theft of cattle of Geryon and stealing the apples of the Hesperides by Herakles.Keywords: Foundation of Gadir, Melqart and Astarte sanctuaries, Arwad, Labours of Herakles.