bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enseñanza de la metodología de la investigación en la educación universitaria.
Authors: Marcano de Blanco Eladia 
Published: September 2023

El propósito de este producto intelectual de investigación es presentar el Estado del Arte sobre la enseñanza de la metodología de la investigación en la educación universitaria, por cuanto este conocimiento que cosifica los hechos a investigar, pareciera que se convierte, gracias a esta manera de ver el método, en uno de los obstáculos epistemológicos más comunes y preocupantes en el fracaso del estudiante universitario, en su construcción de sus productos de investigación. Para ello transitamos en un ejercicio heurístico e interpretativo-crítico en diversas fuentes documentales. Primeramente se toman algunas fuentes importantes, a saber, las estadísticas de la Unesco, en cuanto a la cantidad de investigadores por región del mundo, se consultaron tesis doctorales desde el año 2016 hasta los actuales momentos en las distintas páginas web de las universidades nacionales donde se dicta el programa de Doctorado en Ciencias de la Educación, tales como: La UNESR, ULA, UPEL, UCV, UCAB, USM, URBE, donde no se encontraron antecedentes al respecto, se consultaron universidades internacionales. Se consultaron 25 libros de metodología de la investigación, con el objeto de obtener el concepto de metodología, dando como resultados únicamente tres libros, así como las semejanzas y diferencias de la forma de desarrollar el problema y el proceso de investigación, también se consultaron libros relacionados con la formación investigativa y la Ciencias, entre la búsqueda se seleccionaron 20 artículos de revistas científicas, obteniendo información de la enseñanza de la metodología de la investigación, los obstáculos para investigar. Se puede concluir, que la enseñanza de la metodología debe ser complementada con los distintos enfoques, métodos y paradigmas.
Educación superior en la región: heterogeneidades, desafíos y transformaciones
Authors: Giudice Jacqueline , González Inés 
Published: September 2023

El artículo ofrece un panorama actualizado de la Educación Superior latinoamericana, con foco en el MERCOSUR, desarrollando procesos influyentes en la expansión de la matrícula. En ese sentido, se analiza la evolución e impacto de los 14 años de escolaridad obligatoria en la región; el notable incremento de la participación femenina en todos los niveles educativos y el grado de compromiso en el financiamiento educativo de los países parte. Se focalizan experiencias innovadoras implementadas para lograr mayores tasas de cobertura en regiones y sectores de la población más desfavorecidos, y que permitieron la aparición en Educación Superior de sujetos antes poco representados. También se ofrecen datos de la incidencia de la educación privada, especialmente en Argentina. Se destacan grandes avances aunque también dificultades para que sectores vulnerables asistan a una educación obligatoria de calidad y accedan a la Educación Superior. Gracias a datos actualizados de las tasas de cobertura y permanencia en la Educación Superior en el MERCOSUR, se focaliza en el ingreso de sectores más desfavorecidos de la población. Se ofrece entonces un panorama heterogéneo en el que se destacan análisis que apuntan a las particularidades de los sujetos que hoy constituyen los estudiantes de la Educación Superior. El trabajo concluye con los desafíos pendientes y algunas propuestas en pos de cubrir la tasa de escolarización obligatoria, acortar la brecha según el origen urbano-rural y entre los alumnos de quintiles más desfavorecidos con respecto a los de mejores recursos, para incrementar su representación en ese sector educativo
Debate sobre ensino, pesquisa e extensão na América Latina
Authors: Da Penha dos Santos Aparecida 
Published: September 2023

Dos dias 25 a 27 de Abril de 2023, a Unespar – Universidade Estadual do Paraná– Brasil, realizou o I Congresso Latino-Americano de Ensino, Pesquisa e Extensão (CONLAPE), juntamente com o V Seminário dos Cursos de Ciências Sociais Aplicadas (SECISA). O CONLAPE/SECISA teve como objetivo gerar e divulgar conhecimento, além de oferecer espaço para apresentação de resultados de ações e projetos de ensino, pesquisa e extensão, desenvolvidos no Brasil e em outros países, nas mais variadas áreas do conhecimento. O evento ocorreu na modalidade virtual e sua estrutura foi composta por palestras, mesas-redondas e simpósios temáticos com apresentações de comunicações orais. A abrangência do evento foi além do nível regional, sendo também nacional e global, com ênfase especial para a América Latina.
Portrait des expériences de violences sexuelles intrafamiliales et extrafamiliales dévoilées par les femmes fréquentant des centres d’aide au Québec
Authors: Bergeron Manon , Lavoie Mongrain Catherine , Hébert Martine , Julien Marily 
Published: September 2023

Malgré la forte prévalence de la violence sexuelle au Canada, les connaissances sur les caractéristiques de celle-ci demeurent limitées. Sur la base des données recueillies auprès de 1 824 femmes et adolescentes ayant fait une demande d’aide dans des Centres d’aide et de lutte contre les agressions à caractère sexuel du Québec (CALACS), cet article vise à fournir un portrait des expériences de victimisation sexuelle de ces femmes, de la recherche d’un soutien psychosocial, puis à comparer certaines caractéristiques des situations de violences sexuelles intrafamiliales et extrafamiliales. Les résultats révèlent un taux élevé de revictimisation sexuelle : près de 40 % des répondantes ont rapporté plus de deux situations de violence sexuelle au cours de leur vie. Les situations de violences sexuelles intrafamiliales subies avant l’âge de 18 ans perdurent sur une plus longue période et les personnes victimes les dévoilent plus tardivement que celles rapportant des situations de violences sexuelles extrafamiliales.
Inovação, na prática: um estudo sobre a cultura de inovação em micro e pequenos empreendimentos do comércio do Sertão Central de Pernambuco
Authors: Souza Maria Eduarda da Silva Vieira , Dos Santos Maria Fernanda , Sobral Eryka Fernanda Miranda , De Melo Fagner José Coutinho , Amorim Bartira Pereira , Vital Junior Silvio André , Guimarães Junior Djalma Silva 
Published: September 2023

O objetivo desta pesquisa é analisar a percepção dos gestores das Micro e Pequenas empresas do setor de comércio na região do Sertão Central Pernambucano em relação à cultura de inovação. A pesquisa é de natureza aplicada e classifica-se como descritiva, do tipo Survey, com abordagem quantitativa embasada em pesquisa bibliográfica e aplicação de questionários a fim de mensurar a percepção dos gestores das MPEs. Os resultados indicam que as MPEs do Sertão Central de Pernambuco compreendem a importância da cultura de inovação e a colocam em prática como forma de se manter competitivas no mercado, mesmo que seja mediante inovações incrementais. Desse modo, a pesquisa traz contribuições para os donos, gerentes e colaboradores das MPEs do Sertão Central Pernambucano e demais regiões acerca da temática que os ajudará no desenvolvimento de métricas para que possam acompanhar e avaliar os processos de inovação, ademais na criação de políticas que contribuirá com o crescimento do comércio na região.
Odd Chen Exponential Distribution: Properties and Applications
Authors: Otoo Henry , Inkoom Justice , Wiah Eric N. 
Published: September 2023

In this study, a new statistical distribution with three parameters called the Odd-Chen Exponential has been proposed. The statistical properties of the proposed distribution, such as the quantile, moments, incomplete moments, moment-generating function, and mean residual life, were developed. The density shows different shapes, making it more flexible for analyzing different forms of data. The hazard function also exhibits different shapes, including the well-known bathtub shape, which means that the distribution is flexible with real-life data. To estimate the distribution parameters, ordinary least squares estimators, Cramér-von Mises estimators, and maximum likelihood estimators were derived. The results were compared using a Monte Carlo simulation. Two-time datasets; one from the mining field and the other from survival analysis, were used to check the applicability of the proposed distribution. The results revealed that the OCE distribution performed better than the Odd Chen Weibull, Odd Chen Rayleigh, Rayleigh, Cauchy, Generalised Inverse Weibull and the Modified Extended Chen distributions.
On the Modeling of Causative and Dependence Relationship of Cancers based on Gender and Cumulative Incidence
Authors: Bosson-Amedenu Senyefia , Eduboah Eric Justice , Teku Emmanuel , Ouerfelli Noureddine , Baidoo Ransford Ekow 
Published: September 2023

Objectives: The goal of our study was to model the causative relationship and dependence of morbidity, mortality, and cumulative incidence with respect to GLOBOCAN 2020 age standardized world estimates for female and male malignancies using two adjustable parameters having physical significance.
Methods: The GLOBOCAN age standardized world estimates for patients for the year 2020 were used in this investigation. For the purposes of analyzing descriptive and analytical data, Kaleidagraph and Origin Software were employed. Bivariate empirical cross- correlation and dependency analyses were used to model how the variables were related to one another. The ratio of new cases to fatalities was calculated using equations comparing the stages of various malignancies.
Results: In this work, the use of a two-state parameter resulted in the estimation of the optimal solution. The results demonstrated a non-linear correlation with a progressive increase when the cumulative risk of cancer death for each sex was examined separately versus the global cumulative risk of cancer mortality for both sexes. Males experienced the increase more dramatically than females. This finding suggests that the global male-to-female population ratio is not the only factor contributing to cumulative risk.
Conclusion: South-Eastern Asia, out of all the regions of the world examined in this study, reached its inflection point at (16.23, 14.87). This generates the baseline and standard against which the overall risk of other countries can be measured. The global cumulative risk, which was estimated at 21.50 for females and 17.94 for males, respectively, dropped at this inflection point.
Agro-Waste Biochar to Reduce the Leaching of Heavy Metals from Coal Fly Ash Amended Soil
Authors: Ukwattage N. L.  , Li Y.  , Lakmalie U. V.  , Gan Y.  
Published: September 2023

The soils added with coal fly ash may contain heavy metals potentially up to the levels of toxicity. Biochars have been successfully used in the past to reduce the bioavailability and leaching of heavy metals in contaminated soils. Therefore, the co-application of biochar together with coal fly ash could positively change the bioavailability and leaching characteristics of heavy metals in sandy soils through various fixing mechanisms. In the present study, the authors investigated the effect of agro-waste biochar in modifying the leaching loss of heavy metals from coal fly ash contaminated soils. Column leaching tests with simulated rainfall conditions were conducted for sandy Ultisol soils mixed with coal fly ash and avocado branch cut biomass biochar at 5 tons/ha rate. The results showed the presence of heavy metals in the leachate of fly ash added soil. Application of biochar significantly reduced the leachability of all the tested heavy metals in the study. The reduction rates were up to 55% compared to non-amended samples. Therefore, the agro-waste biochar can effective be used in stabilizing the heavy metals in coal fly ash contaminated soils, to minimize the risk of environmental contamination.
Movimentos do corpo estesiológico em Merleau-Ponty e a experiência da dança
Authors: Nóbrega Terezinha Petrucia da 
Published: September 2023

O objetivo deste ensaio encontra-se nos movimentos para compreender a estesiologia do corpo na obra de Merleau-Ponty, em diálogo com a experiência da dança. A apreciação das obras do filósofo, em particular a Fenomenologia da Percepção, A dúvida de Cézanne, O olho e o Espírito e outros textos publicados postumamente, permitiu-nos percorrer o movimento das ideias sobre corpo e a estesiologia e sua relação com o sentir. Para Merleau-Ponty, o corpo é colocado no centro da experiência, do mundo-vida e das operações reflexivas. Mas, que corpo é esse? Não se trata aqui do corpo marcado pelo racionalismo cartesiano e seus desdobramentos. Mas, sim considerar o corpo sensível exemplar, o corpo dos afetos, da expressão, o corpo como criador de mundos subjetivos e intersubjetivos. Neste movimento, entramos na dança para expressar nuances do corpo estesiológico.
Oral Nanomedicine: Challenges and Opportunities
Authors: Deng Bo , Liu Shaomin , Wang Ying , Ali Barkat , Kong Na , Xie Tian , Koo Seyoung , Ouyang Jiang , Tao Wei 
Published: September 2023

AbstractCompared to injection administration, oral administration is free of discomfort, wound infection, and complications and has a higher compliance rate for patients with diverse diseases. However, oral administration reduces the bioavailability of medicines, especially biologics (e.g., peptides, proteins, and antibodies), due to harsh gastrointestinal biological barriers. In this context, the development and prosperity of nanotechnology have helped improve the bioactivity and oral availability of oral medicines. On this basis, first, the biological barriers to oral administration are discussed, and then oral nanomedicine based on organic and inorganic nanomaterials and their biomedical applications in diverse diseases are reviewed. Finally, the challenges and potential opportunities in the future development of oral nanomedicine, which may provide a vital reference for the eventual clinical transformation and standardized production of oral nanomedicine, are put forward.
Bistable Spin‐Crossover Nanoparticles for Molecular Electronics
Authors: Torres‐Cavanillas Ramón , Gavara‐Edo Miguel , Coronado Eugenio 
Published: September 2023

AbstractThe field of spin‐crossover complexes is rapidly evolving from the study of the spin transition phenomenon to its exploitation in molecular electronics. Such spin transition is gradual in a single‐molecule, while in bulk it can be abrupt, showing sometimes thermal hysteresis and thus a memory effect. A convenient way to keep this bistability while reducing the size of the spin‐crossover material is to process it as nanoparticles (NPs). Here, the most recent advances in the chemical design of these NPs and their integration into electronic devices, paying particular attention to optimizing the switching ratio are reviewed. Then, integrating spin‐crossover NPs over 2D materials is focused to improve the endurance, performance, and detection of the spin state in these hybrid devices.
Photodynamic eradication of intratumoral microbiota with bacteria‐targeted micelles overcomes gemcitabine resistance of pancreatic cancer
Authors: Liu Renfa , Yang Huanyu , Qu Shuai , Yang Peipei , Zhi Xin , Xu Yunxue , Dai Zhifei , Qian Linxue 
Published: September 2023

AbstractIncreasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression, immunosurveillance, metastasis, and chemosensitivity. Particularly, in pancreatic ductal adenocarcinoma, tumor‐resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitabine (Gem) into its inactive form, thus rendering chemotherapy ineffective. Herein, a strategy for selectively eradicating intratumoral bacteria was described for overcoming Gem resistance in a pancreatic cancer animal model. An antimicrobial peptide was linked with photosensitizer through a poly (ethylene glycol) chain, which can self‐assemble into micelles with a diameter of ∼20 nm. The micelles could efficiently kill bacteria under light irradiation by inducing membrane depolarization, thereby inhibiting Gem metabolism. In a bacteria‐resident pancreatic cancer animal model, the selective photodynamic eradication of intratumoral bacteria was demonstrated to efficiently reverse Gem resistance. This research highlights antibacterial photodynamic therapy as a promising adjuvant strategy for cancer therapy by modulating intratumoral microbiota.
Dominant frontonasal dysplasia with ectodermal defects results from increased activity of ALX4
Authors: Peled Alon , Sarig Ofer , Mohamad Janan , Eskin‐Schwartz Marina , Vodo Dan , Bochner Ron , Malchin Natalya , Isakov Ofer , Shomron Noam , Fainberg Gilad , Bertolini Marta , Paus Ralf , Sprecher Eli 
Published: September 2023

AbstractFrontonasal dysplasia (FND) refers to a group of rare developmental disorders characterized by abnormal morphology of the craniofacial region. We studied a family manifesting with clinical features typical for FND2 including neurobehavioral abnormalities, hypotrichosis, hypodontia, and facial dysmorphism. Whole‐exome sequencing analysis identified a novel heterozygous frameshift insertion in ALX4 (c.985_986insGTGC, p.Pro329Argfs*115), encoding aristaless homeobox 4. This and a previously reported dominant FND2‐causing variant are predicted to result in the formation of a similar abnormally elongated protein tail domain. Using a reporter assay, we showed that the elongated ALX4 displays increased activity. ALX4 negatively regulates the Wnt/β‐catenin pathway and accordingly, patient keratinocytes showed altered expression of genes associated with the WNT/β‐catenin pathway, which in turn may underlie ectodermal manifestations in FND2. In conclusion, dominant FND2 with ectodermal dysplasia results from frameshift variants in ALX4 exerting a gain‐of‐function effect.
A Carbene Relay Strategy for Cascade Insertion Reactions
Authors: Li Li , Mi Chenggang , Huang Guanwang , Huang Meirong , Zhu Yuyi , Ni Shao‐Fei , Wang Zhaofeng , Huang Yong 
Published: September 2023

AbstractInsertion reactions that involve stabilized electrophilic metallocarbenes are of great importance for installing α‐heteroatoms to carbonyl compounds. Nevertheless, the limited availability of carbene precursors restricts the introduction of only a single heteroatom. In this report, we describe a new approach based on an I(III)/S(VI) reagent that promotes the cascade insertion of heteroatoms. This is achieved by sequentially generating two α‐heteroatom‐substituted metal carbenes in one reaction. We found that this mixed I(III)/S(VI) ylide reacts efficiently with a transition metal catalyst and an X−H bond (where X=O, N). This transformation leads to the sequential formation of a sulfoxonium‐ and an X‐substituted Rh‐carbenes, enabling further reactions with another Y−H bond. Remarkably, a wide range of symmetrical and unsymmetrical α,α‐O,O‐, α,α‐O,N‐, and α,α‐N,N‐subsituted ketones can be prepared under mild ambient conditions. In addition, we successfully demonstrated other cascades, such as CN/CN double amidation, C−H/C−S double insertion, and C−S/Y−H double insertion (where Y=S, N, O, C). Notably, the latter two cascades enabled the simultaneous installation of three functional groups to the α‐carbon of carbonyl compounds in a single step. These reactions demonstrate the versatility of our approach, allowing for the synthesis of ketones and esters with multiple α‐heteroatoms using a common precursor.
BiBr3‐Mediated Intramolecular Aza‐Prins Cyclization of Aza‐Achmatowicz Rearrangement Products: Asymmetric Total Synthesis of Suaveoline and Sarpagine Alkaloids
Authors: Cheng Wai Fung , Ma Shiqiang , Lai Yin Tung , Cheung Yuen Tsz , Akkarasereenon Kornkamon , Zhou Yiqin , Tong Rongbiao 
Published: September 2023

AbstractAn intramolecular aza‐Prins cyclization of aza‐Achmatowicz rearrangement products was developed in which bismuth tribromide (BiBr3) plays a dual role as an efficient Lewis acid and source of the bromide nucleophile. This approach enables the facile construction of highly functionalized 9‐azabicyclo[3.3.1]nonanes (9‐ABNs), which are valuable synthetic building blocks and a powerful platform for the synthesis of a variety of alkaloid natural products and drug molecules. Suitable substrates for the aza‐Prins cyclization include 1,1‐disubstituted alkenes, 1,2‐disubstituted alkenes, alkynes, and allenes, with good to excellent yields observed. Finally, we showcase the application of this new approach to the enantioselective total synthesis of six indole alkaloids: (−)‐suaveoline (1), (−)‐norsuaveoline (2), (−)‐macrophylline (3), (+)‐normacusine B (4), (+)‐Na‐methyl‐16‐epipericyclivine (5) and (+)‐affinisine (6) in a total of 9–14 steps. This study significantly expands the synthetic utility of the aza‐Achmatowicz rearrangement, and the strategy (aza‐Achmatowicz/aza‐Prins) is expected to be applicable to the total synthesis of other members of the big family of macroline and sarpagine indole alkaloids.
Fluorescent Probes for the Detection of Bone Metabolism
Authors: Zhang Jiawei , Pan Sheng , Song Bin , Xu Youjia , Wang Houyu , He Yao 
Published: September 2023

AbstractThe skeleton plays a significant role in human health. Comprehensive and non‐invasive visualization of the bone is in high demand to detect bone‐related diseases. Clinically, conventional imaging techniques continue to face challenges in terms of limited imaging sensitivity, extended acquisition durations, and the inherent presence of ionizing radiation. These factors collectively hinder their capacity to furnish real‐time spatial insights into cellular activity. Recently, Numerous innovative imaging methodologies employing diverse types of probes have emerged to enhance the clinical detection of bone. In vivo imaging of bone contribute to continuously detecting bone metabolism and growth, diagnosing bone metastases, visualizing medication delivery to bones. Fluorescent probes in dynamic detection of bone metabolism several inherent advantages. First, Fluorescent probes present lower potential long‐term toxicity than radioactive isotope labels. Second, fluorescent dyes used in in vitro imaging are more cost‐effective and come in a more compact size. Next, Near‐infrared (NIR) dyes have deeper tissue penetration capability and lower tissue autofluorescence. However, bone‐imaging fluorescent probes highly depend on phosphonate‐related ligands. These ligands have multiple side effects in clinic and long half‐live of them also exacerbates clearance concerns. This review aims to conclude and analyse the recently reported fluorescent probes for the precise detection of bone. Firstly, we outline the fundamental design mechanism of bone fluorescent probes and describe diverse bone‐targeting moieties, emphasizing the targeting ligands, signal moieties, and functionalities of these probes. Secondly, we discuss the recent promising bone fluorescent probes for the precise and sensitive detection of bone. Finally, we offer our insights on potential future advancements in this field. We anticipate that this review will inspire creative ideas for designing and creating innovative bone‐targeting probes, with applications in bone imaging, pharmaceutical screening, and assessing therapeutic outcomes.