bluuebunny/crossref_metadata_2025_split huggingface dataset:
The translation of Hans Christian Andersen's fairy tales and his intertextual world in China1
Authors: Luo Xuanmin , Zhu Jianchun 
Published: January 2023

AbstractThe retranslations of Andersen's fairy tales in the twentieth century have promoted the canonization of Andersen in the modern Chinese literary system. Today, Chinese readers of different ages are fascinated by Andersen's works and the images created by him. However, the literary and cultural significance of Andersen to China lies in his influence. In this paper, the authors will first review the history of translating Andersen's fairy tales in China and then analyze some cases from Chinese literature and culture within the theoretical framework of intertextuality, in an attempt to specify the influence of Andersen on modern Chinese literature and culture. It is argued that Andersen's fairy tales have been cross‐culturally woven into Chinese children's as well as adult literature when the intertextual devices are applied by writers in their own literary creations; meanwhile the fictional elements of the tales are intertextually merged, as symbols, into other forms of cultural products where they are involved in a critical construction of modern Chinese culture.
Changes in root hydraulic conductivity in wheat (Triticum aestivum L.) in response to salt stress and day/night can best be explained through altered activity of aquaporins
Authors: Lu Yingying , Fricke Wieland 
Published: January 2023

AbstractSalt stress reduces plant water flow during day and night. It is not known to which extent root hydraulic properties change in parallel. To test this idea, hydroponically grown wheat plants were grown at four levels of salt stress (50, 100, 150 and 200 mM NaCl) for 5–8d before harvest (d14–18) and subjected to a range of analyses to determine diurnal changes in hydraulic conductivity (Lp) at cell, root and plant level. Cell pressure probe analyses showed that the Lp of cortex cells was differentially affected by salt stress during day and night, and that the response to salt stress differed between the main axis of roots and lateral roots. The Aquaporin (AQP) inhibitor H2O2 reduced Lp to a common, across treatments, level as observed in salt‐stressed plants during the night. Analyses of transpiring plants and exuding root systems provided values of root Lp which were in the same range as values modeled based on cell‐Lp. The results can best be explained through a change in root Lp in response to salt stress and day/night, which results from an altered activity of AQPs. qPCR gene expression analyses point to possible candidate AQP isoforms.
Factors associated with health‐related quality of life of informal caregivers of older patients and the mediating role of subjective caregivers' burden
Authors: Vrettos Ioannis , Anagnostopoulos Fotios , Voukelatou Panagiota , Panayiotou Stefani , Kyvetos Andreas , Nikas Anastasios , Kollia Dafni , Niakas Dimitris 
Published: January 2023

BackgroundCaregiving has been associated with increased subjective burden and decreased health‐related quality of life (HRQOL) for caregivers. The aim of the study was to clarify the precise relationship between caregivers' burden, caregivers' HRQOL, and other risk factors, considering that subjective burden was a risk factor for poor HRQOL, which may also mediate the effects of some known risk factors.MethodsIn this cross‐sectional study, patients' and their informal caregivers' characteristics were recorded for 311 patient‐caregiver dyads. Subjective caregiver burden and caregivers' HRQOL were assessed using the Zarit Burden Interview and the 12‐item Short‐Form Health Survey (SF‐12), respectively. Mediation analysis was used to examine the relationships between variables. Caregivers' mental component summary (MCS) and physical component summary (PCS) scores were regarded as outcome variables, caregivers' subjective burden was considered the mediator, and patients' and caregivers' characteristics were treated as predictors.ResultsCaregivers' subjective burden was negatively related to both PCS and MCS of caregivers' HRQOL, after controlling for the effects of demographic and clinical variables. Moreover, significant associations, mostly indirect via caregivers' subjective burden, existed between caregivers' socio‐demographic characteristics, duration of caregiving, patients' frailty status, patients' co‐morbidity, and caregivers' HRQOL.ConclusionCaregivers' subjective burden plays a major and mediating role on influencing caregivers' HRQOL. Our findings may direct future research and promote the implementation of interventions to reduce caregivers' burden and improve caregivers' HRQOL.
Exploring word choice and narrative framing in trump's trade tweets
Authors: Fattore Christina , Wagner Karsyn 
Published: January 2023

AbstractObjectivesIn this article, we examine whether former President Trump utilized Twitter to craft a narrative regarding international trade via his use of Twitter.MethodsWe examine Trump's language choices in a corpus of his tweets to compare his tone in trade‐related tweets against his more general tweets during his presidency.ResultsWe find that Trump's trade tweets contain language that is more cognitively complex, masculine, and honest, compared to his non‐trade‐focused tweets.ConclusionThis study illustrates Trump's ability to craft and maintain a narrative about trade based on exaggeration and manipulations, in line with populist leadership theory.
Nano‐RECall provides an integrated pipeline for HIV‐1 drug resistance testing from Oxford Nanopore sequence data
Authors: Delaney Kayla Eileen , Ngobeni Trevor , Woods Conan K. , Gordijn Carli , Claassen Mathilda , Parikh Urvi , Harrigan P. Richard , van Zyl Gert Uves 
Published: January 2023

AbstractObjectivesLow‐capital‐layout sequencing options from Oxford Nanopore Technologies (ONT) could assist in expanding HIV drug resistance testing to resource‐limited settings. HIV drug resistance mutations often occur as mixtures, but current ONT pipelines provide a consensus sequence only. Moreover, there is no integrated pipeline that provides a drug resistance report from an ONT sequence file without intervention from skilled bioinformaticists. We therefore investigated Nano‐RECall, which provides seamless drug resistance interpretation while requiring low‐read coverage ONT sequence data from affordable Flongle or MinION flow cells and which provides mutation mixtures similar to Sanger Sequencing.MethodsWe compared Sanger sequencing to ONT sequencing of the same HIV‐1 subtype C polymerase chain reaction (PCR) amplicons, respectively using RECall and the novel Nano‐RECall bioinformatics pipelines. Amplicons were from separate assays: (a) Applied Biosystems HIV‐1 Genotyping Kit (ThermoFisher) spanning protease (PR) to reverse transcriptase (RT) (PR‐RT) (n = 46) and (b) homebrew integrase (IN) (n = 21). The agreement between Sanger sequences and ONT sequences was assessed at nucleotide level, and at codon level for Stanford HIV drug resistance database mutations at an optimal ONT read depth of 400 reads only.ResultsThe average sequence similarity between ONT and Sanger sequences was 99.3% (95% CI: 99.1%–99.4%) for PR‐RT and 99.6% (95% CI: 99.4%–99.7%) for INT. Drug resistance mutations did not differ for 21 IN specimens; 8 mutations were detected by both ONT‐ and Sanger sequencing. For the 46 PR and RT specimens, 245 mutations were detected by either ONT or Sanger, of these 238 (97.1%) were detected by both.ConclusionsThe Nano‐RECall pipeline, freely available as a downloadable application on a Windows computer, provides Sanger‐equivalent HIV drug resistance interpretation. This novel pipeline combined with a simple workflow and multiplexing samples on ONT flow‐cells would contribute to making HIV drug resistance sequencing feasible for resource‐limited settings.
Advances in sustainable wastewater treatment: Microalgal–bacterial consortia process, greenhouse gas reduction and energy recovery technologies
Authors: Guo Qingyang , Qi Feng , Mu Ruimin , Yu Gejiang , Ma Guixia , Meng Qianya 
Published: January 2023

AbstractBecause of the low energy consumption of aeration, strong nutrient removal capacity, low greenhouse gas emissions and high resource recovery potential, the wastewater treatment process using microalgal–bacterial consortia is considered as an excellent alternative to the traditional activated sludge wastewater treatment process. In this review, the wastewater treatment process based on microalgal–bacterial consortia and its greenhouse gas emission reduction mechanism are introduced. The potential advantages and constraints of the process in carbon neutral wastewater treatment were highlighted and critically discussed. The environmental impact of wastewater treatment, the research progress of environment‐friendly treatment technologies and the challenges faced by integrating these technologies are discussed. However, the wastewater treatment process based on microalgae–bacteria consortia still needs to be studied. In the future, it is necessary to optimize the scheme for quantifying the environmental impact of wastewater treatment and further expand the recycling rate and cost value of wastewater resources.
Effectiveness of suture button fixation versus screw fixation for the management of acute distal tibiofibular syndesmotic injuries: a systematic review protocol
Authors: Cehic Matthew G. , Jaarsma Ruurd , Whitehorn Ashley 
Published: January 2023

Objective:
The aim of this review is to determine whether suture button fixation is more effective than traditional screw fixation for the management of acute distal tibiofibular syndesmotic injuries.

Introduction:
Syndesmotic injuries are common and require surgical management to avoid chronic pain and instability, and to improve long-term functional outcomes. Screw fixation and suture button fixation are the 2 techniques of choice for treatment; however, there remains ongoing debate surrounding which treatment modality delivers the best outcomes, leading to significant variability in practice. The suture button is a relatively new technique; therefore, there is a need for an updated, high-quality systematic review to help guide best practice in syndesmosis injury management.

Inclusion criteria:
This review will consider studies comparing suture button versus screw fixation of acute (<6 weeks) distal tibiofibular syndesmotic injuries. Patients aged 18 or over, with syndesmotic injuries requiring surgical stabilization, with or without an associated fracture, will be included. The primary outcome of interest will be composite functional ankle scores. Secondary outcomes will include range of motion, pain, joint malreduction, complications rates, re-operation rates, and return to work/sport.

Methods:
This review will be conducted in accordance with the JBI guidelines for systematic reviews of effectiveness. The following electronic databases will be searched: PubMed, Embase, Scopus, The Cochrane Register of Controlled Trials, and Web of Science, in addition to gray literature databases. No publication date or language limits will be applied. Two independent reviewers will screen titles, abstracts, and full-text studies, assessing methodological quality using the JBI critical appraisal tools. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach will be used to assess certainty in the findings.

Systematic review registration number:
PROSPERO CRD42022331211
Management of basal cell carcinoma with pulmonary metastasis
Authors: Fordham Samuel Achilles , Shao Emily Ximin , Banney Leith , Azer Mary , Dettrick Andrew 
Published: January 2023

A man in his 50s presented with an ulcerative lesion within the left axillary fold that had progressively worsened over 18 months. Biopsy revealed an ulcerative basal cell carcinoma (BCC), which was surgically managed. CT chest scans done 7 months later assessed post-treatment of radiotherapy. This revealed pulmonary lesions, which were biopsy-proven metastatic BCC. Sonidegib, a hedgehog signalling inhibitor, was used for first-line treatment. Due to progressive disease, sonidegib was ceased. Cemiplimab, a checkpoint inhibitor, was used as second-line treatment based on a phase II trial demonstrating efficacy in the setting of metastatic BCC. CT reports were initially consistent with response but after 6 months of cemiplimab treatment, repeat CT chest scans revealed a decrease in size of the previously cited pulmonary lesions.This is a rare case of BCC metastases which has limited treatment options. This case provides insight of the patient experience on such treatment.
Investigating the autoregulation of applied blood flow restriction training pressures in healthy, physically active adults: an intervention study evaluating acute training responses and safety
Authors: Jacobs Ewoud , Rolnick Nicholas , Wezenbeek Evi , Stroobant Lenka , Capelleman Robbe , Arnout Nele , Witvrouw Erik , Schuermans Joke 
Published: January 2023

ObjectiveTo examine the effects of autoregulated (AUTO) and non-autoregulated (NAUTO) blood flow restriction (BFR) application on adverse effects, performance, cardiovascular and perceptual responses during resistance exercise.MethodsFifty-six healthy participants underwent AUTO and NAUTO BFR resistance exercise in a randomised crossover design using a training session with fixed amount of repetitions and a training session until volitional failure. Cardiovascular parameters, rate of perceived effort (RPE), rate of perceived discomfort (RPD) and number of repetitions were investigated after training, while the presence of delayed onset muscle soreness (DOMS) was verified 24 hours post-session. Adverse events during or following training were also monitored.ResultsAUTO outperformed NAUTO in the failure protocol (p<0.001), while AUTO scored significantly lower for DOMS 24 hours after exercise (p<0.001). Perceptions of effort and discomfort were significantly higher in NAUTO compared with AUTO in both fixed (RPE: p=0.014, RPD: p<0.001) and failure protocol (RPE: p=0.028, RPD: p<0.001). Sixteen adverse events (7.14%) were recorded, with a sevenfold incidence in the fixed protocol for NAUTO compared with AUTO (NAUTO: n=7 vs AUTO: n=1) and five (NAUTO) vs three (AUTO) adverse events in the failure protocol. No significant differences in cardiovascular parameters were found comparing both pressure applications.ConclusionAutoregulation appears to enhance safety and performance in both fixed and failure BFR-training protocols. AUTO BFR training did not seem to affect cardiovascular stress differently, but was associated with lower DOMS, perceived effort and discomfort compared with NAUTO.Trial registration numberNCT04996680.
Metrics, baseline scores, and a tool to improve sponsor performance on clinical trial diversity: retrospective cross sectional study
Authors: Varma Tanvee , Mello Michelle , Ross Joseph S , Gross Cary , Miller Jennifer 
Published: January 2023

ObjectiveTo develop a measure for fair inclusion in pivotal trials by assessing transparency and representation of enrolled women, older adults (aged 65 years and older), and racially and ethnically minoritized patients.DesignRetrospective cross sectional study.PopulationSponsors of novel oncology therapeutics that were approved by the US Food and Drug Administration over 1 January 2012 to 31 December 2017.Data sourcesTrial data from Drugs@FDA, ClinicalTrials.gov, and corresponding publications; cancer incidence demographics from US Cancer Statistics and the American Cancer Society.Main outcome measuresTransparency measures assess whether trials publicly report participant sex, age, and racial and ethnic identity. Representation measures assess whether trial participant demographics represent more than 80% of the US patient population for studied conditions, calculated by dividing the percentage of study participants in each demographic subgroup by the percentage of the US cancer population with the studied condition per group. Composite fair inclusion measures assess average transparency and representation scores, overall and for each demographic group. Results are reported at the trial, product, and sponsor levels.ResultsBetween 1 January 2012 and 31 December 2017, the FDA approved 59 novel cancer therapeutics, submitted by 25 sponsors (all industry companies) on the basis of 64 pivotal trials. All 25 sponsors (100%) reported participant sex, 10 (40%) reported age, and six (24%) reported race and ethnicity. Although 14 (56%) sponsors had adequate representation of women in trials, only six (24%) adequately represented older adults, and four (16%) adequately represented racially and ethnically minoritized patients (black, Asian, Hispanic or Latinx). On overall fair inclusion, one sponsor scored 100% and the median sponsor score was 81% (interquartile range 75-87%). More than half of sponsors (13 (56%) of 25) fairly included women, 20% (n=5) fairly included older adults, and 4% (n=1) fairly included racially and ethnically minoritized patients in trials. 80% of product had pivotal trials that fairly included women, 24% fairly included older adults, and 5% fairly included racially and ethnically minoritized patients.ConclusionsThis novel approach evaluates trials, products, and sponsors on their fair inclusion of demographic groups in research. For oncology trials, substantial room was noted for improved inclusion of older adults and patients who identify as black or Latinx and transparency around the number of participants identifying as Native Hawaiian, Pacific Islander, American Indian, and Alaska Native. These measures can be used by sponsors, ethics committees, among others, to set and evaluate trial diversity goals to help spur progress toward greater research equity in the US.
Investigating the usefulness of Automated Check-in Data Collection in general practice (AC DC Study): a multicentre, cross-sectional study in England
Authors: Lawton Sarah , Mallen Christian , Muller Sara , Wathall Simon , Helliwell Toby 
Published: January 2023

ObjectivesTo investigate the usefulness of using automated appointment check-in screens to collect brief research data from patients, prior to their general practice consultation.DesignA descriptive, cross-sectional study.SettingNine general practices in the West Midlands, UK. Recruitment commenced in Autumn 2018 and was concluded by 31 March 2019.ParticipantsAll patients aged 18 years and above, self-completing an automated check-in screen prior to their general practice consultation, were invited to participate during a 3-week recruitment period.Primary and secondary outcome measuresThe response rate to the use of the automated check-in screen as a research data collection tool was the primary outcome measure. Secondary outcomes included responses to the two research questions and an assessment of impact of check-in completion on general practice operationalisationResultsOver 85% (n=9274) of patients self-completing an automated check-in screen participated in the Automated Check-in Data Collection Study (61.0% (n=5653) women, mean age 55.1 years (range 18–98 years, SD=18.5)). 96.2% (n=8922) of participants answered a ‘clinical’ research question, reporting the degree of bodily pain experienced during the past 4 weeks: 32.9% (n=2937) experienced no pain, 28.1% (n=2507) very mild or mild pain and 39.0% (n=3478) moderate, severe or very severe pain. 89.3% (n=8285) of participants answered a ‘non-clinical’ research question on contact regarding future research studies: 46.9% (n=3889) of participants responded ‘Yes, I’d be happy for you to contact me about research of relevance to me’.ConclusionsUsing automated check-in facilities to integrate research into routine general practice is a potentially useful way to collect brief research data from patients. With the COVID-19 pandemic initiating an extensive digital transformation in society, now is an ideal time to build on these opportunities and investigate alternative, innovative ways to collect research data.Trial registration numberISRCTN82531292.
Comparison of medication adherence to different oral anticoagulants: population-based cohort study
Authors: Ingason Arnar B , Hreinsson Jóhann P , Lund Sigrún H , Ágústsson Arnar S , Rumba Edward , Pálsson Daníel A , Reynisson Indriði E , Guðmundsdóttir Brynja R , Önundarson Páll T , Björnsson Einar S 
Published: January 2023

ObjectivePrevious observational studies have yielded conflicting results on whether medication adherence differs between patients receiving warfarin and direct oral anticoagulants (DOACs). Importantly, no study has adequately accounted for warfarin dosing being continuously modified based on INR values while dosing of DOACs is fixed. We aimed to compare non-adherence between new users of apixaban, dabigatran, rivaroxaban and warfarin in a population-based cohort.MethodsNew users of apixaban, dabigatran, rivaroxaban and warfarin from 2014 to 2019 living in the Icelandic capital area were included. Non-adherence was defined as proportion of days covered below 80%. Inverse probability weighting was used to yield balanced study groups and non-adherence was compared using logistic regression. Factors associated with non-adherence were estimated using multivariable logistic regression.ResultsOverall, 1266 patients received apixaban, 247 dabigatran, 1566 rivaroxaban and 768 warfarin. The proportion of patients with non-adherence ranged from 10.5% to 16.7%. Dabigatran was associated with significantly higher odds of non-adherence compared with apixaban (OR 1.57, 95% CI 1.21 to 2.04, p<0.001), rivaroxaban (OR 1.45, 95% CI 1.12 to 1.89, p=0.005) and warfarin (OR 1.63, 95% CI 1.23 to 2.15, p<0.001). The odds of non-adherence were similar for apixaban, rivaroxaban and warfarin. Apart from the type of oral anticoagulants (OACs) used, female sex, hypertension, history of cerebrovascular accident and concomitant statin use were all independently associated with lower odds of non-adherence.ConclusionDabigatran was associated with higher odds of non-adherence compared with other OACs. Non-adherence was similar between apixaban, rivaroxaban and warfarin users. Female sex and higher comorbidity were associated with better medication adherence.
Assistive technology in palliative medicine: equipment needs
Authors: Kelly Renae , Manning Bridget , Broome Kieran 
Published: January 2023

ObjectivesMost people prefer to die at home. Timely and appropriate provision of assistive technology can support people to remain at home in the palliative phase. A state-wide palliative care equipment programme (PCEP) was established in Queensland, Australia, to support coordinated assistive technology provision. The objective of this study was to identify population-wide palliative care equipment needs and their relationship to primary diagnostic categories.MethodA retrospective, cross-sectional analysis of equipment provided over a 19-month period was conducted. This included types of equipment provided and characteristics of the participants such as rurality, age and diagnostic category.ResultsThere were 13 764 approved equipment requests, with a median time between equipment application and death being around 35 days. There were significant differences in the types of equipment typically required across diagnostic categories.ConclusionThe findings from the study can provide a benchmark for the development of population-wide PCEPs. For practitioners who are new to palliative care, typical trajectories of equipment needs by diagnostic group can help guide equipment planning.