bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Godelieve Denys-Struyf (GDS) muscle and articulation chain treatment on clinical variables of patients with chronic low back pain and lumbar disc degeneration: a pilot feasibility randomized controlled trial
Authors: Lombardo Sidsel , Hilde Gunvor , Småstuen Milada Cvancarova , Grotle Margreth 
Published: March 2023

Abstract
Background
Patients with chronic low back pain (LBP) and lumbar disc degeneration are recommended to try out nonsurgical treatment options before surgery. There is need for good nonsurgical alternatives that can be adapted to the patient’s needs and level of function. The aim of this pilot trial was to test study feasibility of a future full randomized controlled trial (RCT) evaluating the feasibility and benefit of the physiotherapy-based Godelieve Denys-Struyf (GDS) muscle and articulation chain treatment for patients with chronic LBP and lumbar disc degeneration referred to surgical assessment in a hospital outpatient clinic.

Methods
This study is a single-center, two-arm, single-blinded, pilot RCT conducted in a regional hospital in Norway. Patients of age 35–75 years with chronic (> 3 months) LBP and degenerative lumbar disc(s) verified by imaging were included. They filled in a baseline questionnaire prior to randomization, including the Oswestry Disability Index (ODI), numerical rating scale for pain in back and pain in leg, and the EuroQoL 5L. Patients in the control group were free to use treatment as usual. Patients in the intervention group received 8 sessions over a period of 10 to 14 weeks of GDS muscle and articulation chain treatment.

Results
The recruitment rate was slow, approximately 3/4th of the referred patients met the inclusion criteria, but majority of eligible participants (94%) were willing to participate. A total of 30 patients were randomized into the two groups. The randomization led to skewed distribution of radiating leg pain in the two groups. All participants except one (97%) completed 4 months follow-up. No serious adverse events attributable to the trial treatments were reported. The Oswestry Disability Index (ODI) and leg pain intensity scale were both suitable as primary outcomes in a full trial. The mean change in the ODI score was 8.7 (SD 16.1) points in the GDS arm, whereas there was a minor deterioration in the ODI scores of −3.7 (7.5) points in the control arm. A sample size calculation based on the ODI scores resulted in a number needed to treat of 3.

Conclusions
A future full RCT is feasible and would provide evidence about the effectiveness of a GDS treatment for patients with chronic LBP and lumbar disc degeneration.

Trial registration
ClinicalTrials.gov ID: 910193.
Albumin-binding photosensitizer capable of targeting glioma via the SPARC pathway
Authors: Li Xingshu , Oh Jae Sang , Lee Yoonji , Lee Eun Chae , Yang Mengyao , Kwon Nahyun , Ha Tae Won , Hong Dong-Yong , Song Yena , Kim Hyun Kyu , Song Byung Hoo , Choi Sun , Lee Man Ryul , Yoon Juyoung 
Published: March 2023

Abstract

Background
Malignant glioma is among the most lethal and frequently occurring brain tumors, and the average survival period is 15 months. Existing chemotherapy has low tolerance and low blood-brain barrier (BBB) permeability; therefore, the required drug dose cannot be accurately delivered to the tumor site, resulting in an insufficient drug effect.

Methods
Herein, we demonstrate a precision photodynamic tumor therapy using a photosensitizer (ZnPcS) capable of binding to albumin in situ, which can increase the permeability of the BBB and accurately target glioma. Albumin-binding ZnPcS was designed to pass through the BBB and bind to secreted protein acidic and rich in cysteine (SPARC), which is abundant in the glioma plasma membrane.

Results

When the upper part of a mouse brain was irradiated using a laser (0.2 W cm
− 2
) after transplantation of glioma and injection of ZnPcS, tumor growth was inhibited by approximately 83.6%, and the 50% survival rate of the treatment group increased by 14 days compared to the control group. In glioma with knockout SPARC, the amount of ZnPcS entering the glioma was reduced by 63.1%, indicating that it can target glioma through the SPARC pathway.

Conclusion
This study showed that the use of albumin-binding photosensitizers is promising for the treatment of malignant gliomas.

Graphical Abstract
Is a correlation-based investment strategy beneficial for long-term international portfolio investors?
Authors: Narayan Seema Wati , Rehman Mobeen Ur , Ren Yi-Shuai , Ma Chaoqun 
Published: March 2023

AbstractUsing negative to low-correlated assets to manage short-term portfolio risk is not uncommon among investors, although the long-term benefits of this strategy remain unclear. This study examines the long-term benefits of the correlation strategy for portfolios based on the stock market in Asia, Central and Eastern Europe, the Middle East and North Africa, and Latin America from 2000 to 2016. Our strategy is as follows. We develop five portfolios based on the average unconditional correlation between domestic and foreign assets from 2000 to 2016. This yields five regional portfolios based on low to high correlations. In the presence of selected economic and financial conditions, long-term diversification gains for each regional portfolio are evaluated using a panel cointegration-based testing method. Consistent across all portfolios and regions, our key cointegration results suggest that selecting a low-correlated portfolio to maximize diversification gains does not necessarily result in long-term diversification gains. Our empirical method, which also permits the estimation of cointegrating regressions, provides the opportunity to evaluate the impact of oil prices, U.S. stock market fluctuations, and investor sentiments on regional portfolios, as well as to hedge against these fluctuations. Finally, we extend our data to cover the years 2017–2022 and find that our main findings are robust.
Artificial intelligence applications and ethical challenges in oral and maxillo-facial cosmetic surgery: a narrative review
Authors: Rokhshad Rata , Keyhan Seied Omid , Yousefi Parisa 
Published: March 2023

AbstractArtificial intelligence (AI) refers to using technologies to simulate human cognition to solve a specific problem. The rapid development of AI in the health sector has been attributed to the improvement of computing speed, exponential increase in data production, and routine data collection. In this paper, we review the current applications of AI for oral and maxillofacial (OMF) cosmetic surgery to provide surgeons with the fundamental technical elements needed to understand its potential. AI plays an increasingly important role in OMF cosmetic surgery in various settings, and its usage may raise ethical issues. In addition to machine learning algorithms (a subtype of AI), convolutional neural networks (a subtype of deep learning) are widely used in OMF cosmetic surgeries. Depending on their complexity, these networks can extract and process the elementary characteristics of an image. They are, therefore, commonly used in the diagnostic process for medical images and facial photos. AI algorithms have been used to assist surgeons with diagnosis, therapeutic decisions, preoperative planning, and outcome prediction and evaluation. AI algorithms complement human skills while minimizing shortcomings through their capabilities to learn, classify, predict, and detect. This algorithm should, however, be rigorously evaluated clinically, and a systematic ethical reflection should be conducted regarding data protection, diversity, and transparency. It is possible to revolutionize the practice of functional and aesthetic surgeries with 3D simulation models and AI models. Planning, decision-making, and evaluation during and after surgery can be improved with simulation systems. A surgical AI model can also perform time-consuming or challenging tasks for surgeons.
Sequential central retinal artery occlusions associated with cryoglobulinemia
Authors: Wang Patrick , Kanda Pushpinder , Wang Yao , Bal Manpartap 
Published: March 2023

Abstract
Background
Cryoglobulinemia, the presence of serum cryoglobulins which are immunoglobulins or complement components that precipitate at temperatures below 37 °C, commonly present with cutaneous manifestations initially, but are more rarely associated with ocular manifestations. To our knowledge, we report the first case of a patient presenting with sequential central retinal artery occlusion (CRAO) associated with cryoglobulinemia.

Case presentation
A 69-year-old female with a history of indolent B-cell lymphoma associated cryoglobulinemia, treated hepatitis B infection and CRAO in the left eye presented with acute vision loss and diffuse retinal whitening with a cherry red spot in her right eye, suggestive of sequential CRAO. Laboratory studies revealed a cryocrit of 55% (normal  < 1%), elevated titres of cryoglobulin IgG at 1.98 g/L and cryoglobulin IgM at 3.78 g/L (normal  < 0.3 g/L)9, and elevated kappa free light chain at 283.5 mg/L (normal  < 0.06 g/L). Such elevated tires of cryoglobulins in the context of the patient’s CRAO raised suspicion of cryoglobulinemia associated CRAO. The patient was promptly referred to rheumatology and oncology and was admitted for treatment including intravenous methylprednisone, rituximab and bendamustine chemotherapy.

Conclusions
We report a patient with a complex medical history presenting with significant vision loss due to a sequential CRAO likely associated with cryoglobulinemia. Although a direct relationship between cryoglobulinemia and CRAO cannot be confirmed in this case, it highlights the importance of considering cryoglobulinemia in high-risk patients with prior history of hematological malignancy or chronic hepatitis infection.
Are all primary retinal detachments the same? Anatomic and functional differences between phakic and pseudophakic patients
Authors: Gibelalde Ane , Pinar-Sueiro Sergio , Ibarrondo Oliver , Martínez-Soroa Itziar , Mendicute Javier , Ruiz Miguel Miguel 
Published: March 2023

Abstract
Background
Given differences in the pathogenic mechanisms underlying primary retinal detachment (RD) as a function of the status of the lens, the objective was to explore differences between pseudophakic and phakic patients with primary RD.

Methods
A retrospective study including 821 patients who underwent surgery for RD [491 cases of phakic and 330 of pseudophakic RD (pRD and psRD, respectively)] in our hospital between 2012 and 2020.

Results
The mean age was 58.24 ± 12.76 years in the pRD group and 66.87 ± 11.18 years in the psRD group (p = 0.001). There were more men in both groups (70% and 64.23% of pseudophakic and phakic patients, respectively; p = 0.07). The most common location for the RD was superior in both groups (43.94% and 51.93% of pseudophakic and phakic patients, respectively), rates of inferior and total RD were somewhat higher in the psRD group (31.82% and 13.33% in pseudophakic vs 25.25% and 11.0% in phakic patients, p = 0.001). In pseudophakic and phakic patients respectively, macular involvement in 69.09% and 62.73% of cases (p = 0.067). Proliferative vitreoretinopathy was significantly more common in the psRD group (7.88% vs 3.6% in phakic patients, p = 0.01).The rate of final anatomic reattachment differed markedly between groups, with a higher rate in phakic (94.03%) than pseudophakic (87.27%) patients (p = 0.001).

Conclusions
The specific pathogenic mechanism involved in psRD seems to be responsible for worse evolution characteristics which are associated with poorer final anatomic and functional outcomes in pseudophakic patients.
Clinicopathological classification of immune checkpoint inhibitor-associated myocarditis: possible refinement by measuring macrophage abundance
Authors: Jimenez Jesus , Kostelecky Nicolas , Mitchell Joshua D. , Zhang Kathleen W. , Lin Chieh-Yu , Lenihan Daniel J. , Lavine Kory J. 
Published: March 2023

Abstract
Background
Immune checkpoint inhibitor (ICI) myocarditis is associated with high morbidity and mortality. While endomyocardial biopsy (EMB) is considered a gold standard for diagnosis, the sensitivity of EMB is not well defined. Additionally, the pathological features that correlate with the clinical diagnosis of ICI-associated myocarditis remain incompletely understood.

Methods
We retrospectively identified and reviewed the clinicopathological features of 26 patients with suspected ICI-associated myocarditis based on institutional major and minor criteria. Seventeen of these patients underwent EMB, and the histopathological features were assessed by routine hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) staining for CD68, a macrophage marker.

Results
Only 2/17 EMBs obtained from patients with suspected ICI myocarditis satisfied the Dallas criteria. Supplemental IHC staining and quantification of CD68+ macrophages identified an additional 7 patients with pathological features of myocardial inflammation (> 50 CD68+ cells/HPF). Macrophage abundance positively correlated with serum Troponin I (P = 0.010) and NT-proBNP (N-terminal pro-brain natriuretic peptide, P = 0.047) concentration. Inclusion of CD68 IHC could have potentially changed the certainty of the diagnosis of ICI-associated myocarditis to definite in 6/17 cases.

Conclusions
While the Dallas criteria can identify a subset of ICI-associated myocarditis patients, quantification of macrophage abundance may expand the diagnostic role of EMB. Failure to meet the traditional Dallas Criteria should not exclude the diagnosis of myocarditis.
Misplacement of left ventricular vent into the aortic root during a re-do Bentall procedure: a case report
Authors: Kumamoto Taisuke , Hiraoka Chieko , Murakami Kotaro , Fujita Miki , Kunitoku Yuji , Kato Kiyohiko 
Published: March 2023

Abstract

Background
The left ventricular (LV) vent is commonly inserted via the right superior pulmonary vein (RSPV) and directed toward the LV cavity through the mitral valve. We report a rare case in which the tip of the LV vent was misplaced into the aortic root across the aortic valve.

Case presentation
An 88-year-old man was scheduled to undergo the Bentall procedure. After initiation of cardiopulmonary bypass, the LV vent was inserted via the RSPV. Anterograde cardioplegia was administered via the aortic root cannula after the ascending aorta was cross-clamped. The electrocardiogram did not result in complete cardiac arrest, even after delivery of two-thirds of the planned dose. A transesophageal echocardiographic examination showed that the tip of the LV vent was misplaced into the aortic root across the aortic valve.

Conclusions
It is important to confirm the tip position by transesophageal echocardiography to prevent severe complications associated with the LV vent.
Falls leading to fracture and nutrition among older adults: a case–control study
Authors: Ardaneh Mahdieh , Fararouei Mohammad , Hassanzadeh Jafar 
Published: March 2023

Abstract
Objectives
Injurious falls, especially those leading to bone fracture, are major causes of death and disability among older people. Our aim was to measure the association of nutritional factors and physical activity with falls leading to fracture among Iranian older adults.

Methods
This is the second phase of a previously published case–control study on 300 patients and 590 controls.

Results
In addition to the socio-economic factors that were reported before, our results revealed that consumption of fish, vegetables, fruits, and nuts reduced the risk of falling, whereas consumption of cheese, red meat, and sweets raised the risk of falls among the participants.

Conclusion
The results of our study suggested that diets rich in fish meat fruits and vegetables should be encouraged in the everyday life of older adults. We suggest health officials to take these important results into consideration when planning protective measures.
Customizable document control solution for 3D printing at the point-of-care
Authors: Lohss Maxwell , Hammersley Elliott , Ghodadra Anish 
Published: March 2023

Abstract
Background
The rapid expansion and anticipated U.S Food and Drug Administration regulation of 3D printing at the point-of-care necessitates the creation of robust quality management systems. A critical component of any quality management system is a document control system for the organization, tracking, signature collection, and distribution of manufacturing documentation. While off-the-shelf solutions for document control exist, external programs are costly and come with network security concerns. Here, we present our internally developed, cost-effective solution for an electronic document control system for 3D printing at the point-of-care.

Methods
We created a hybrid document control system by linking two commercially available platforms, Microsoft SharePoint and Adobe Sign, using a customized document approval workflow.

Results
Our platform meets all Code of Federal Regulations Title 21, Part 11 guidances.

Conclusion
Our hybrid solution for document control provides an affordable system for users to sort, manage, store, edit, and sign documents. The system can serve as a framework for other 3D printing programs to prepare for future U.S Food and Drug Administration regulation, improve the efficiency of 3D printing at the point-of-care, and enhance the quality of work produced by their respective program.
Evaluating the effectiveness of different perceptual training methods in a difficult visual discrimination task with ultrasound images
Authors: Marris Jessica E. , Perfors Andrew , Mitchell David , Wang Wayland , McCusker Mark W. , Lovell Timothy John Haynes , Gibson Robert N. , Gaillard Frank , Howe Piers D. L. 
Published: March 2023

AbstractRecent work has shown that perceptual training can be used to improve the performance of novices in real-world visual classification tasks with medical images, but it is unclear which perceptual training methods are the most effective, especially for difficult medical image discrimination tasks. We investigated several different perceptual training methods with medically naïve participants in a difficult radiology task: identifying the degree of hepatic steatosis (fatty infiltration of the liver) in liver ultrasound images. In Experiment 1a (N = 90), participants completed four sessions of standard perceptual training, and participants in Experiment 1b (N = 71) completed four sessions of comparison training. There was a significant post-training improvement for both types of training, although performance was better when the trained task aligned with the task participants were tested on. In both experiments, performance initially improves rapidly, with learning becoming more gradual after the first training session. In Experiment 2 (N = 200), we explored the hypothesis that performance could be improved by combining perceptual training with explicit annotated feedback presented in a stepwise fashion. Although participants improved in all training conditions, performance was similar regardless of whether participants were given annotations, or underwent training in a stepwise fashion, both, or neither. Overall, we found that perceptual training can rapidly improve performance on a difficult radiology task, albeit not to a comparable level as expert performance, and that similar levels of performance were achieved across the perceptual training paradigms we compared.
Attitudes and perceptions towards postpartum contraceptive use among seroconcordant partners with HIV in rural Mozambique: a qualitative study
Authors: Sack Daniel E. , Emílio Almiro , Graves Erin , Matino Ariano , Paulo Paula , Aboobacar Arifo U. , De Schacht Caroline , Audet Carolyn M. 
Published: March 2023

Abstract
Background
Postpartum contraceptive uptake reduces short interpregnancy intervals, unintended pregnancies, and their negative sequalae: poor maternal and fetal outcomes. Healthy timing and spacing of pregnancy in people living with HIV (PLHIV) also allows time to achieve viral suppression to reduce parent-to-child HIV transmission. There is scant understanding about how couples-based interventions impact postpartum contraceptive uptake among PLHIV in sub-Saharan Africa.

Methods
We interviewed 38 recently pregnant people and 26 of their partners enrolled in the intervention arm of the Homens para Saúde Mais (HoPS+) [Men for Health Plus] trial to assess their perceptions of, attitudes towards, and experiences with contraceptive use. Individuals in the HoPS+ intervention arm received joint—as opposed to individual—HIV-related services during pregnancy and postpartum periods, six counseling and skills sessions, and nine sessions with a peer support couple. Our thematic analysis of the 64 in-depth interviews generated 14 deductive codes and 3 inductive codes across themes within the Information, Motivation, and Behavior Model of health behavior change.

Results
Participants reported accurate and inaccurate information about birth spacing and contraceptive methods. They described personal (health, economic, and religious) and social (gender norms, desired number of children) motivations for deciding whether to use contraceptives—with slightly different motivations among pregnant and non-pregnant partners. Finally, they explained the skills needed to overcome barriers to contraceptive use including how engagement in HoPS+ improved their shared decision-making skills and respect amongst partners—which facilitated postpartum contraceptive uptake. There were also several cases where non-pregnant partners unilaterally made family planning decisions despite disagreement from their partner.

Conclusions
These findings suggest that couples-based interventions during pregnancy and post-partum periods aimed at increasing postpartum contraceptive uptake must center pregnant partners’ desires. Specifically, pregnant partners should be allowed to titrate the level of non-pregnant partner involvement in intervention activities to avoid potentially emboldening harmful gender-based intercouple decision-making dynamics.
A high efficiency multi-module parallel RF inverter system for plasma induced hydrogen
Authors: Yao Tingting , Guan Yueshi , Wang Wei 
Published: March 2023

AbstractHydrogen energy plays an important role in achieving carbon neutralization, and plasma induced hydrogen is an effective production method. One challenge is how to guarantee high efficiency operation with wide power output range of the RF inverter system used to generate the plasma. In this paper, a multi-module parallel topology of a high-frequency inverter is analyzed, in which the power combining network can maintain the soft switching characteristics of the inverter modules. A control method of "ON/OFF + phase shift" is adopted to broaden the output power range of the inverter. The equivalent impedances of different modules are analyzed in detail. A four-module 13.56 MHz high-frequency inverter prototype is built and tested. The results show that the inverter can operate at high efficiency and wide output power range with efficiency improved by at least 5% compared with the traditional parameter design method without considering the effect of paralleled modules.