bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single‐Cell RNA‐Sequencing of Zebrafish Olfactory Epithelium Identifies Odor‐Responsive Candidate Olfactory Receptors
Authors: Takaoka Misaki , Hiraki‐Kajiyama Towako , Miyasaka Nobuhiko , Hino Takahiro , Kondo Kenji , Yoshihara Yoshihiro 
Published: January 2025

ABSTRACTSingle‐cell RNA‐sequencing (scRNA‐seq) is a powerful method to comprehensively overlook gene expression profiles of individual cells in various tissues, providing fundamental datasets for classification of cell types and further functional analyses. Here we adopted scRNA‐seq analysis for the zebrafish olfactory sensory neurons which respond to water‐borne odorants and pheromones to elicit various behaviors crucial for survival and species preservation. Firstly, a single‐cell dissociation procedure of the zebrafish olfactory rosettes was optimized by using cold‐active protease, minimizing artifactual neuronal activation. Secondly, various cell types were classified into distinct clusters, based on the expressions of well‐defined marker genes. Notably, we validated non‐overlapping expressions of different families of olfactory receptors among the clusters of olfactory sensory neurons. Lastly, we succeeded in estimating candidate olfactory receptors responding to a particular odor stimulus by carefully scrutinizing correlated expressions of immediate early genes. Thus, scRNA‐seq is a useful measure for the analysis of olfactory sensory neurons not only in classifying functional cell types but also in identifying olfactory receptor genes for given odorants and pheromones.
Who Has the Right to Express Frustration?: Uneven Emotion Labor Among Students in an EMI Classroom
Authors: Song Juyoung 
Published: January 2025

ABSTRACTThis study explores college students’ emotional experiences in an English as a medium of instruction (EMI) course at a Korean university. The data include interviews and classroom observations conducted over a semester. The analysis reveals that students’ emotional experiences and management—referred to as emotion labor—are intricately connected with language ideologies that prioritize English within multilingual classrooms and beyond. The findings indicate that the hegemony of English and native speakerism positions native speakers in a superior role, leading to varied emotional experiences among students and differing levels of engagement in emotion labor. Specifically, these language ideologies prioritize native speakers’ emotional experiences, enabling them to express their frustration more freely. In contrast, non‐native English speakers often suppress their frustration, disappointment, and resentment related to perceived unfairness, instead of channeling these emotions into a desire for the symbolic and imaginative capital associated with English and the positive opportunities that EMI courses might offer. The study highlights how power dynamics and language hierarchies differentially influence students’ perceived “right to express” emotions and underscores the need for consistent language policies and more inclusive EMI environments to support students’ emotional well‐being and academic success.
Exploring the Artistic Identity of Elementary Art Teachers
Authors: Carpenter Estrada Tara , Neves Molly , Broadbent Connie , Aina Kara , Wadham Rachel 
Published: January 2025

AbstractArt teachers straddle two identities those of a teacher and those of an artist. While these two identities may complement each other it is clear that, particularly for elementary art teachers, they are often in conflict. As art teachers look towards balancing this dichotomy, they must discover what is necessary to equalise and maintain both their teaching and artistic identities. This self‐study offers the practical reflections of three elementary art teachers to identify some trends and connections between developing teacher identities and the strategies they use to maintain an artistic identity. Discovering how elementary art teachers prioritise their own artistic practice shows us that as they balance both identities, they can gain energy and inspiration from their practice while at the same time allowing their students to benefit from their deeper understanding of the art world.
Where Does Insensitivity Lie? How IT Investment Decision Practices Shape Supply Chain Efficiency
Authors: Bradley Randy V. , Bichescu Bogdan C. , Cha Junwoo , Bell John E. , Esper Terry , Hazen Ben 
Published: January 2025

ABSTRACTHospitals are searching for ways to improve supply chain efficiency. Drawing on the success of supply chain digitization in other industries, hospitals have increased their efforts to digitize supply chain operations via investments in IT to address pain points associated with supply disruptions and rising costs, including supply costs that account for more than 40% of operating expenses. Prior research fails to consider how IT investment decisions are justified concerning their impact on supply chain performance when the decision‐maker sits outside the supply chain function. We draw on the Practice‐Based Theory to explain how IT investment decision practices affect hospital supply chain efficiency (SCE). We use matched survey responses from hospital CIOs and IT managers and secondary data to examine the direct and indirect effects of various IT investment justification practices on SCE. We also investigate the role of moderated mediation effects. Leveraging PBT, we establish a different type of organizational practice in the supply chain management and logistics literature: IT investment justification practices. We extend the PBT and empirically challenge the implicit assumption that supply chain performance is not sensitive to IT investment decisions. Further, we demonstrate which IT investment justification practice is more beneficial to supply chain efficiency.
Autophagy Associated Genes (ARGs) ‐Based Predictive Model AIDPS for Prostate Cancer
Authors: Zhao Zhiyi , Yang Yongjin , Sun Zhou , Fan LianMing , Liu Lingyun 
Published: January 2025

ABSTRACTProstate cancer (PCa) is one of the most common cancers in men worldwide. Autophagy‐related genes (ARGs) may play an important role in various biological processes of PCa. The aim of this study was to identify and evaluate autophagy‐related features to predict clinical outcomes in patients with PCa. Single‐cell sequencing data and RNA sequencing data was included from public GEO and TCGA databases. Cells were clustered and annotated by dimension reduction cluster analysis. Epithelial cells, T cells and fibroblasts were isolated to explore their heterogeneity. Autophagy‐related genes were obtained from the HADb database. Survival analysis was conducted by K–M curve, and prognostic risk model was established using 101 machine learning algorithms. In addition, we performed gene colocalisation analysis and Mendelian randomisation analysis. Univariate Cox analysis was used to screen out prognostic genes from DEGs and ARGs in each dataset. Risk model was generated by artificial intelligence‐derived prognostic signature (AIDPS), which showed better prognostic performance in every dataset than other published models for PCa. The disease‐free period (DFS) of patients in the high‐risk group was significantly worse than that in the low‐risk group (all p < 0.05). The best model is the Ridge (C‐index 0.726). We found significant differences in IC50 values of the Dactinomycin_1811, Dactolisib_1057, Luminespib_1559 and Paclitaxel_1080 between groups. In SNP sites rs2743987 and rs7768988, there was a significant correlation between prostate hyperplasia and prostate cancer. Our ARG‐based predictive model AIDPS is a reliable and effective tool for prognosis and treatment of prostate cancer.
Genetic Commonalities Between Metabolic Syndrome and Rheumatic Diseases Through Disease Interactome Modules
Authors: Shi Yinli , Guan Shuang , Liu Xi , Zhai Hongjun , Zhang Yingying , Liu Jun , Yang Weibin , Wang Zhong 
Published: January 2025

ABSTRACTThis study aims to elucidate the potential genetic commonalities between metabolic syndrome (MetS) and rheumatic diseases through a disease interactome network, according to publicly available large‐scale genome‐wide association studies (GWAS). The analysis included linkage disequilibrium score regression analysis, cross trait meta‐analysis and colocalisation analysis to identify common genetic overlap. Using modular partitioning, the network‐based association between the two disease proteins in the protein–protein interaction set was divided and quantified. Clinical samples from public databases were used to confirm the mapped genes. Mendelian randomisation analyses were conducted using genetic instrumental variables for causal inference. MetS and rheumatoid arthritis (RA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), Sjogren's syndrome (SS) and their primary module networks shared topological overlap and genetic correlation. Functional analysis highlighted the significance of these shared targets in processes such as a diverse array of metabolic pathways involving glucose, lipids, energy, protein transport, inflammatory response, autophagy and cytokine regulation, elucidating the pathways through which MetS intersects with rheumatic diseases. Causal associations were determined between MetS phenotypes and rheumatic diseases. The persistence of MetS effects on rheumatic diseases remained evident even after adjusting for alcohol consumption and smoking. We have highlighted specific genetic associations between MetS and rheumatic diseases. Several genes (e.g., PRRC2A, PSMB8, BAG6, GPSM3, PBX2, etc.) have been identified with molecular commonalities in MetS and RA, AS, SLE and SS, which may serve as potential targets for shared treatments.
Variation in the diet composition and weight–length relationship of small characids in urbanized and forested streams
Authors: de Souza Emanuelly Costa Ventura , Gouveia E. J. , Nascimento T. J. S. , Mendes S. G. F. , Ferreira A. , Araújo R. P. , Oliveira K. M. P. , Dagosta F. C. P. , Russo M. R. 
Published: January 2025

AbstractThe diet of indicator fish species plays a crucial role in assessing ecosystem health. This study evaluated streams with and without urban influences, focusing on abiotic parameters and the trophic ecology of Psalidodon fasciatus and Piabina argentea. Forested streams exhibited higher redox potential, dissolved oxygen, transparency, and depth, whereas urban streams had higher temperatures, greater widths, and increased levels of total dissolved solids, conductivity, total coliforms, and thermotolerant coliforms. The P. fasciatus population exhibited isometric growth in forested streams and negative allometric growth in urban streams. Conversely, P. argentea exhibited negative allometric growth in both types of environment. The diets of both species included items of autochthonous and allochthonous origin. P. fasciatus had a similar diet in both stream types, whereas P. argentea's diet varied significantly between forested and urban streams. These findings highlight the importance of understanding the interplay between environmental characteristics and species diets, offering crucial insights into the health status of streams, especially those impacted by urbanization.
Analyzing mental health among Black immigrant families through intersectionality
Authors: Hinson Jacinta D. , Weiser Dana 
Published: January 2025

AbstractWith the Black immigrant population in the United States rapidly increasing, there is a pressing need to understand their unique challenges. We examine the mental health issues of Black immigrant families in the US through the lens of intersectionality. We explore how overlapping identities, race, immigration status, and socioeconomic conditions impact mental health outcomes. Despite their growing numbers, Black immigrants remain underrepresented in mental health research, facing barriers such as language, cultural stigma, and limited access to services. Specific findings reveal how structural racism and migration stress compound to worsen mental health outcomes. This review highlights the importance of targeted, culturally sensitive interventions and comprehensive healthcare practices by analyzing these factors. We advocate for an intersectional approach to address systemic barriers and improve mental health outcomes for Black immigrant families, emphasizing the urgent need for expanded research to promote social justice and equity.
Why is traditional polygamy unjust? Implications for egalitarian nonmonogamy
Authors: Sriwannawit Perri 
Published: January 2025

AbstractThe notion of equality attracts both proponents and critics of nonmonogamy. Inequality is a widely discussed objection to nonmonogamy. Simultaneously, equality is highlighted as a core value in ethical nonmonogamy. The notions of equality and inequality in these debates have not been clearly conceptualized. In order to propose a conception of egalitarian nonmonogamy, it is important to first understand possible inequalities within it. This paper establishes a clearer and in‐depth understanding of inequalities in nonmonogamy by categorizing inequalities in traditional polygamy into different kinds. I argue that these inequalities are generally unjust. Although these inequalities are common in traditional polygamy, the objection that polygamy—as a type of marriage—is inherently unequal and unjust is not a convincing argument. By contrast, not all kinds of equality—such as equal love or equal number of partners—are morally significant. I conclude this paper by providing some groundwork for future research on egalitarian nonmonogamy.
Molecular and biochemical evolution of casbene‐type diterpene and sesquiterpene biosynthesis in rice
Authors: Zhou Shen , Zhan Chuansong , Zhu Jinjin , Yang Chenkun , Zhao Qiaoqiao , Sun Yangyang , Zhou Junjie , Shen Shuangqian , Luo Jie 
Published: January 2025

ABSTRACTCasbene and neocembrene are casbene‐type macrocyclic diterpenes; their derivatives play significant roles in plant defense and have pharmaceutical applications. We had previously characterized a casbene synthase, TERPENE SYNTHASE 28 (OsTPS28), in rice (Oryza sativa). However, the mechanism of neocembrene biosynthesis in rice remained unclear. In this study, we identified two genes of the TPS‐a1 subfamily, OsTPS2 and OsTPS10, encoding a neocembrene synthase and sesquiterpene synthase, respectively, as supported by enzyme activity assays and determination of subcellular localization. Metabolic profiling of rice lines overexpressing either TPS confirmed the catalytic functions of OsTPS2 and OsTPS10, and suggested that OsTPS10 enhances resistance to rice bacterial blight. An evolutionary analysis revealed that OsTPS10 is conserved in monocots and first appeared in wild rice, whereas OsTPS2 and OsTPS28 sequentially evolved through gene duplication, transit peptide recruitment, and mutation of key amino acids such as H362R. In summary, this study not only deepens our understanding of the metabolic pathways and evolutionary history governing the biosynthesis of casbene‐type diterpenoids in rice, representing parallel and divergent evolution within the gene family, and offers gene resources for the improvement of rice.
Impact of Pediatric Posterior Fossa Tumor Treatments on Working Memory Tracts Using Resting‐State fMRI and Tractography
Authors: Habibi Abir Troudi , Alaya Ines Ben , Tensaouti Fatima , Baudou Eloïse , Arribarat Germain , Pollidoro Lisa , Péran Patrice , Chaix Yves , Labidi Salam , Laprie Anne 
Published: January 2025

ABSTRACTBackground and PurposeWorking memory, a primary cognitive domain, is often impaired in pediatric brain tumor survivors, affecting their attention and processing speed. This study investigated the long‐term effects of treatments, including surgery, radiotherapy (RT), and chemotherapy (CT), on working memory tracts in children with posterior fossa tumors (PFTs) using resting‐state functional MRI (rs‐fMRI) and diffusion MRI tractography.MethodsThis study included 16 medulloblastoma (MB) survivors treated with postoperative RT and CT, 14 pilocytic astrocytoma (PA) survivors treated with surgery alone, and 16 healthy controls from the Imaging Memory after Pediatric Cancer in children, adolescents, and young adults study (NCT04324450). Working memory tracts were identified by combining seed masks from rs‐fMRI maps and whole‐brain tractography from diffusion MRI. Connectivity alterations were assessed qualitatively and quantitatively, alongside neuropsychological evaluations and correlations with behavioral outcomes and mean supratentorial dose.ResultsCompared to controls, MB survivors exhibited significant impairments in the working memory network, including reductions in tract volume (TV), fiber density, fiber cross‐section (FC), mean streamline length (MLS), and fractional anisotropy (FA) (all p = 0.04). Lower working memory scores were correlated with reduced TV and FA in MB survivors. Higher mean supratentorial doses were associated with lower TV, FC, and FA values across multiple tracts, particularly in the arcuate and superior longitudinal fasciculi.ConclusionsTractography‐derived features highlighted white matter damage as a biomarker of treatment‐related neurotoxicity in PFTs survivors. These findings underscore the detrimental impact of RT and CT on working memory networks and emphasize the importance of preserving cognitive function during treatment planning.
Becoming as Open‐Minded and Organized as My Classmates? Peer Effects on Self‐Reported Personality Trait Development in the Classroom
Authors: Johannsen Mieke , Brandt Naemi D. , Lüdtke Oliver , Wagner Jenny 
Published: January 2025

ABSTRACTIntroductionHow does a student's personality development relate to the personality of their classmates? The school class builds a pertinent comparison group during adolescence that has been identified as a critical factor in students' development of abilities and self‐perceptions. This study empirically tests the impact of classroom personality composition on changes in adolescents' Big Five personality traits. We hypothesized positive associations between class‐level openness and conscientiousness and the individual development of these traits given their role in academic performance.MethodTo test these hypotheses and explore additional composition effects, we employed three approaches of multilevel structural equation modeling on two large longitudinal samples of German adolescents (N1 = 5470; N2 = 788).ResultsOur analyses yielded two principal findings: First, individual personality levels remained highly stable across different time periods. Second, contrary to our hypotheses, baseline class‐level openness and conscientiousness were not positively linked to individual personality development. Instead, there were some indications that higher class‐level openness was negatively linked to individual openness to experiences at the second measurement point.ConclusionsWe discuss the absence of systematic composition effects at the classroom level and consider methodological challenges in investigating these effects.
Persuasion in Networks With Strategic Substitutes
Authors: Li Guopeng , Sun Yang 
Published: January 2025

ABSTRACTWe study Bayesian persuasion with local strategic substitutes in networks. A designer commits to a public signal to maximize total activity. Equilibria are characterized by the network's maximum ‐insulated sets for each realization. We solve the optimal information structure and characterize beneficial persuasion. While agents individually prefer higher states, the designer's payoff is non‐monotonic in the posterior mean due to substitution effects. This provides a rationale for downwardplaying mechanisms: revealing low states truthfully and mixing signals when high. Moreover, for tree, nested split, and core‐periphery networks, the designer strictly benefits if the prior mean insulated set size is less than the highest state set size.
Preliminary feasibility and efficacy of a brief behavioural treatment for insomnia after acquired brain injury: A case series
Authors: Gardani Maria , Baylan Satu , Zouhar Veronika 
Published: January 2025

SummaryInsomnia after acquired brain injury (ABI) is common and can negatively impact an individual's rehabilitation, recovery, and quality of life. The present study investigated the feasibility and preliminary efficacy of a Brief Behavioural Treatment for Insomnia (BBTI) in a community sample following ABI. Ten participants were recruited. Seven participants attended four weekly sessions of BBTI and kept a daily sleep diary. Participants completed a semi‐structured sleep interview at baseline and self‐report measures of sleep, anxiety, and depression pre‐ and post‐treatment as well as a treatment acceptability questionnaire post‐treatment. Follow‐up data were collected at 1‐, 2‐, and 3‐months post‐treatment. Visual analyses of the data were performed on a case‐by‐case basis. Five of the seven participants (71%) no longer met the criteria for insomnia disorder on the Sleep Condition Indicator (SCI) post‐treatment. Treatment effects on sleep outcomes were either maintained or augmented at follow‐ups. BBTI was found to be well tolerated, as evidenced by the high overall retention rates (70%) and positive feedback on the treatment acceptability questionnaire. These results provide preliminary evidence of BBTI being both feasible to use and potentially efficacious in individuals with post‐brain‐injury insomnia. Larger‐scale randomised controlled trials are needed to establish the effectiveness of BBTI following ABI.
The Theory of Social Representation: Its Various Models and Their Imbrication
Authors: Lo Monaco Grégory , Rateau Patrick 
Published: January 2025

ABSTRACTThis article begins with a summary of the four major theoretical and methodological models of social representations—the sociogenetic, structural, sociodynamic and dialogical models—and then explores new and original approaches to integrating these frameworks. The aim is to move beyond the mere accumulation or juxtaposition usually used in presenting these models and to propose methods for imbricating and interweaving them from three perspectives: conceptual innovation, methodological innovation and the temporal logic of research. We demonstrate how these imbrications—though still requiring extensive empirical research—facilitate a better understanding of how individuals and groups represent the objects in their environment.