bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reticular Chemistry of the Fcu‐Type Gd(III)‐Doped Metal–Organic Framework for T1‐Weighted Magnetic Resonance Imaging
Authors: Qiu Tianze , Wu Tianze , Lu Mingzhu , Xie Yuxi , Zhang Mengmeng , Luo Dan , Chen Zhenxia , Yin Bo , Zhou Yaming , Ling Yun 
Published: July 2023

AbstractNanoscale metal–organic frameworks (nanoMOFs) are emerging as an important class of nanomaterials for the systematical investigation of biomedically relevant structure‐property relationship (SPR) due to their highly tailorable features. In this work, the reticular chemistry approach is shown to explore the SPR of a fcu‐type Zr(IV)‐nanoMOF for T1‐weighted magnetic resonance imaging (MRI). Isoreticular replacement of the eight‐coordinated square‐antiprismatic Zr(IV) by nine‐coordinated Gd(III) brings a stoichiometric water capped on the square‐antiprismatic site, enabling the relaxation transfer in the inner‐sphere, giving the r1 value of 4.55 mM−1·s−1 at the doping ratio of Gd : Zr = 1 : 1. Then, these isoreticular engineering studies provide feasible ways to facilitate the relaxation transfer in the second‐ and outer‐sphere of the Gd(III)‐doped Zr‐oxo cluster for the relaxation respectively. Finally, these in vitro and in vivo MRI studies revealed that the Gd(III)‐doped Zr‐oxo cluster aggregated underlying the fcu‐type framework surpasses its discrete molecular cluster for MRI. These results demonstrated that there is plenty of room inside MOFs for T1‐weighted MRI by reticular chemistry.
Formic Acid‐Regulated Defect Engineering in Zr‐Based Metal‐Organic Frameworks toward Fluorescence Sensor for Sensitive Detection of Chlortetracycline
Authors: Jia Pei , Wu Qiushuang , Sun Boyang , Wang Li 
Published: July 2023

AbstractThe elaborate defect‐engineering of luminescent metal‐organic frameworks (MOFs) allows them with enhanced sensing performance. A modulator‐induced defect formation strategy is adopted in this paper, and the impact of the open‐metal sites on sensing process is rationalized. It is demonstrated that the defect level can be tuned to a remarkable extent by controlling the amount of modulator. When a particular defect concentration is reached, the UiO‐66‐xFA can be acted as highly sensitive ratiometric fluorescence probes for chlortetracycline (CTE) determination with an ultralow detection limit of 9.9 nm. Furthermore, by virtue of the obvious variation in fluorescence chromaticity of probes from blue to yellow, a sensory hydrogels‐based smartphone platform is proposed for visible quantitation of CTE by identifying the RGB values. A delicate device integrated with UV lamp and dark cavity has been developed for avoiding inconsistencies of ambient light and visual errors. Finally, the sensor obtains satisfactory results in the detection of actual seafood samples, with no significant differences from those of liquid chromatography−mass spectrometry. This approach anticipates a novel route to sensitize optical sensors through the design and synthesis of moderate defects in luminescent MOFs.
Tackling the Challenges of Aqueous Zn‐Ion Batteries via Polymer‐Derived Strategies
Authors: Liu Qun , Yu Zhenlu , Zhang Biao 
Published: July 2023

AbstractZn‐ion batteries (ZIBs) have gathered unprecedented interest recently benefiting from their intrinsic safety, affordability, and environmental benignity. Nevertheless, their practical implementation is hampered by low rate performance, inferior Zn2+ diffusion kinetics, and undesired parasitic reactions. Innovative solutions are put forth to address these issues by optimizing the electrodes, separators, electrolytes, and interfaces. Remarkably, polymers with inherent properties of low‐density, high processability, structural flexibility, and superior stability show great promising in tackling the challenges. Herein, the recent progress in the synthesis and customization of functional polymers in aqueous ZIBs is outlined. The recent implementations of polymers into each component are summarized, with a focus on the inherent mechanisms underlying their unique functions. The challenges of incorporating polymers into practical ZIBs are also discussed and possible solutions to circumvent them are proposed. It is hoped that such a deep analysis could accelerate the design of polymer‐derived approaches to boost the performance of ZIBs and other aqueous battery systems as they share similarities in many aspects.
CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non‐small‐cell lung cancer via miR‐590‐5p/SOX5 axis
Authors: Wu Bin , Wang Xisheng , Yu Ruilin , Xue Xingkui 
Published: July 2023

AbstractDysregulated circWHSC1 has been shown to play potential roles in diverse cancer types, including ovarian cancer, endometrial cancer and hepatocellular carcinoma (HCC). The objective of this study was to investigate its expression, underlying role and regulatory mechanism in non‐small‐cell lung cancer (NSCLC). The expression of circWHSC1 was determined by real‐time PCR. After knockdown of circWHSC1 expression in NSCLC cells, the proliferation, migration, and invasion were detected using CCK‐8, colony formation, and Transwell assays, and the effects of circWHSC1 on NSCLC tumorigenesis in vivo was also investigated. With the help of luciferase reporter and pull‐down assays, we further explored the downstream mechanism of circWHSC1 in NSCLC cells. CircWHSC1 was highly expressed in NSCLC tissues and cell lines. The inhibition of circWHSC1 suppressed the malignant properties of NSCLC cells, as evidenced by the reduction of proliferation, migration and invasion. CircWHSC1 sponged miR‐590‐5p and functioned as an oncogene in NSCLC by increasing sex determining region Y‐boxprotein 5 (SOX5) expression. CircWHSC1 may contribute to the oncogenicity of NSCLC via the regulation of miR‐590‐5p/SOX5 axis, which might be a novel therapeutic target in NSCLC.
Global prevalence of Neospora caninum in rodents: A systematic review and meta‐analysis
Authors: Hamzavi Yazdan , Salimi Yahya , Ahmadi Mobin , Adimi Parvaneh , Falahi Sahab , Bozorgomid Arezoo 
Published: July 2023

AbstractBackgroundNeosporosis has been considered a cause of abortion in dairy and beef cattle worldwide. Rodents are reservoir hosts for several infectious diseases. It is necessary to determine the prevalence of Neospora caninum in rodents to improve the current understanding of the transmission dynamics of Neospora as well as its life cycle and risk of transmission to livestock. Therefore, the objective of the present study was to estimate the pooled global prevalence of N. caninum in different rodent species.MethodsPublished studies on the prevalence of N. caninum in different rodent species were searched in the MEDLINE/PubMed, ScienceDirect, Web of Science, Scopus and Google Scholar and the reference lists of the retrieved articles until July 30, 2022. The eligible studies were selected using inclusion and exclusion criteria. The extracted data were verified and analysed using the random‐effect meta‐analysis.ResultFor this meta‐analysis, a total of 4372 rodents from 26 eligible studies were included. The global prevalence of N. caninum in rodents was estimated at 5% (95% CI 2%–9%), with the highest prevalence in Asia (12%; 95% CI 6%–24%) and lowest prevalence in America (3%; 95% CI 1%–14%) and Europe (3%; 95% CI 1%–6%). N. caninum was more prevalent in females (4%; 95% CI 2%–9%) than in males (3%; 95% CI 1%–11%). The most common diagnostic test was polymerase chain reaction (PCR) (21 studies). The pooled prevalence of N. caninum in rodents based on the diagnostic method was as follows: immunohistochemistry: 11% (95% CI 6%–20%), NAT: 5% (95% CI 4%–7%), IFAT: 5% (95% CI 2%–13%) and PCR: 3% (95% CI 1%–9%).ConclusionThe results of this study showed a relatively low but widespread prevalence of N. caninum infection in rodents.
Knowledge, attitudes and biosecurity practices among the small‐scale dairy farmers in Sylhet district, Bangladesh
Authors: Chowdhury Tonmoy , Ahmed Junayed , Hossain Md Tafazzal , Roy Mithu Chandra , Ashik‐Uz‐Zaman Md , Uddin Md Nazim , Rahman Md Masudur , Kabir Md Golam , Hossain Ferdaus Mohd Altaf 
Published: July 2023

AbstractBackgroundIn the context of zoonosis, Bangladesh's small‐scale dairying is yet to frame satisfactory levels due to poor biosecurity practices.ObjectivesThis study intended to reveal the degree of knowledge, attitudes and biosecurity practices among Sylhet district, Bangladesh's small‐scale dairy farmers. We also focused on the association between biosecurity practices and the incidence of non‐specific enteritis in humans.MethodsA questionnaire‐based survey was conducted on the farmers’ KAP via personal interviews of 15 farmers from the randomly selected fifteen small‐scale dairy farms. The questionnaire was developed with 6 questions for knowledge, 6 questions for attitude and 12 questions for the practice of biosecurity measures. Alongside that, data on the number of non‐specific enteritis cases experienced by the farmers or their family members were also recorded. Spearman correlation was used to find out the correlation among KAP variables and between practice scores and non‐specific enteritis incidences.ResultsWe found an insignificant (p > 0.05) influence of demographic characteristics over knowledge, attitude and biosecurity practices. Significant (p < 0.05) and strong correlations were found in knowledge–attitude (r = 0.65), knowledge–practice (r = 0.71) and attitude–practice (r = 0.64). Incidences of non‐specific enteritis and biosecurity measures’ practice were also strongly correlated (r = −0.9232) and statistically significant (p < 0.05).ConclusionsOur study suggests that increasing knowledge and developing a good attitude are necessary to increase the adaptation of biosecurity measures as three of these factors are correlated. Moreover, farm biosecurity measures are closely related to human health.
Model‐free closed‐loop wind farm control using reinforcement learning with recursive least squares
Authors: Liew Jaime , Göçmen Tuhfe , Lio Wai Hou , Larsen Gunner Chr. 
Published: July 2023

AbstractWind farms experience significant power losses due to wake interactions between turbines. Research shows that wake steering can alleviate these losses by redirecting the flow through the farm. However, dynamic closed‐loop implementations of wake steering are rarely presented. We present a model‐free closed‐loop control method using reinforcement learning methodology known as policy gradients in combination with recursive least squares to perform real‐time wake steering in a wind farm. We present dynamic simulations of a four‐turbine wind farm row using HAWC2Farm, implementing the reinforcement learning control method for various inflow conditions and controller configurations. By controlling the three most upstream turbines, mean power gains of
and
(95% confidence interval) are observed in partial wake and full wake conditions respectively at 7.5% turbulence intensity. The study helps to bridge the gap between theoretical wind farm control and real‐world wind farm systems.
Improved disinfection byproduct removal using a polysulfone membrane loaded with powdered activated carbon
Authors: Hou Yizhi , Mayer Brooke K. 
Published: July 2023

AbstractPowdered activated carbon was immobilized by casting it in a polysulfone polymer membrane, which was then tested for disinfection byproduct (chloroform) and bacteria (Escherichia coli) removal. The membrane prepared using 90% T20 carbon and 10% polysulfone (M20‐90) provided a filtration capacity of 2783 L m−2, adsorption capacity of 2.85 mg g−1, and 95% chloroform removal in a 10 s empty bed contact time. Flaws and cracks on the membrane surface caused by the carbon particles appeared to reduce chloroform and E. coli removal. To overcome this challenge, up to six layers of the M20‐90 membrane were overlapped, which improved chloroform filtration capacity by 94.6%, to 5416 L m−2, and increased the adsorption capacity by 93.3%, to 5.51 mg g−1. E. coli removal also increased from 2.5 logs reduction using a single membrane layer to 6.3 logs using six layers under 10 psi feed pressure. The filtration flux declined from 6.94 m3 m−2 day−1 psi−1 for a single layer (0.45 mm thick) to 1.26 m3 m−2 day−1 psi−1 for the six‐layer membrane system (2.7 mm thick). This work demonstrated the feasibility of using powdered activated carbon immobilized on a membrane to improve chloroform adsorption and filtration capacity while simultaneously removing microbes.Practitioner Points
Powdered activated carbon was immobilized on a membrane to improve chloroform adsorption and filtration capacity while simultaneously removing microbes.
Membranes made with the smaller carbon particles (T20) delivered better chloroform adsorption performance.
Use of multiple layers of the membrane further improved chloroform and Escherichia coli removal.
Effects of rotation and electric bias in the semi‐infinite piezoelectric medium on Rayleigh wave velocity
Authors: Yuan Xiaoguang , Gao Zefeng , Hao Chaoyu , Jiang Quan 
Published: July 2023

AbstractThe properties of Rayleigh wave velocity are analyzed by considering the rotation and electric bias. The algebraic equation is derived for determining the piezoelectric Rayleigh wave velocity analytically and numerically for Lithium Niobate. The main results reveal that the rotation as well as electric bias has exerted an appreciable influence on the wave velocity. Particularly, the Coriolis force under the rotatory condition can decrease wave velocity considerably, and such attributes are significant for the acoustic electronics.
On buoyancy‐driven viscous incompressible flows with various types of boundary conditions
Authors: Beneš Michal , Kučera Petr , Vacková Petra 
Published: July 2023

AbstractIn this paper, we study the existence and uniqueness of solutions to the initial‐boundary‐value problem for time‐dependent flows of heat‐conducting incompressible fluids through the two‐dimensional channel. The boundary conditions are of two types: the so‐called “do nothing” boundary condition on the outflow and the so‐called Navier boundary conditions on the solid walls of the channel. A priori estimates play a crucial role in existential analysis, however, the considered mixed boundary conditions do not enable us to derive an energy‐type estimate of the solution. Our aim is to prove the existence and uniqueness of a solution on a sufficiently short time interval for arbitrarily large data.
Alltägliche Lebenssituation von Kindern mit sprachlichen Beeinträchtigungen als handlungstheoretisch fundierter diagnostischer Gegenstand: Entwicklung, Erprobung und Evaluation eines Analyseverfahrens für die pädagogische Sprachdiagnostik
Authors: Schlüter Saskia 
Published: July 2023

ZusammenfassungIm vorliegenden Kapitel steht das im Rahmen der vorliegenden Arbeit eigenständig entwickelte Verfahren zur Erfassung und Auswertung von Informationen zur alltäglichen Lebenssituation von Schulkindern mit sprachlichen Beeinträchtigungen im Mittelpunkt. Bei der Vorgehensweise zur Erfassung und Auswertung wird wie folgt vorgegangen: Eine diagnostizierende Person führt ein Gespräch mit dem an der Diagnostik beteiligten Kind und fragt gezielt nach alltäglichen Handlungen und Handlungsbegründungen. Das Gespräch wird protokolliert, um die Notizen für die spätere Auswertung nutzen zu können.
Zusammenfassung, Diskussion und Reflexion des gesamten theoretischen und empirischen Prozesses
Authors: Schlüter Saskia 
Published: July 2023

ZusammenfassungIn Kapitel 7 werden zentrale Befunde der vorliegenden Arbeit zusammengefasst, diskutiert und reflektiert. Zunächst wird eine theoretische Zusammenfassung (7.1) vorgenommen, bei der die vier theoretischen Bezugssysteme im Fokus stehen, um mit Bezug auf dieses theoretische Fundament im nachfolgenden Abschnitt die Beantwortung der Forschungsfragen (7.2) vornehmen zu können. Es werden also die erste Forschungsfrage der vorliegenden Arbeit nach der Konzeptualisierung von alltäglicher Lebenssituation sowie die zweite Forschungsfrage der vorliegenden Arbeit nach der methodischen Umsetzung der Erfassung und Auswertung von Informationen zur alltäglichen Lebenssituation von Schulkindern mit sprachlichen Beeinträchtigungen beantwortet.
Equation of state and speed of sound of isospin-asymmetric QCD on the lattice
Authors: Brandt B. B. , Cuteri F. , Endrődi G. 
Published: July 2023

Abstract
We determine the QCD equation of state at nonzero temperature in the presence of an isospin asymmetry between the light quark chemical potentials on the lattice. Our simulations employ Nf = 2 + 1 flavors of dynamical staggered quarks at physical masses, using three different lattice spacings. The main results, obtained at the individual lattice spacings, are based on a two-dimensional spline interpolation of the isospin density, from which all relevant quantities can be obtained analytically. In particular, we present results for the pressure, the interaction measure, the energy and entropy densities, as well as the speed of sound. Remarkably, the latter is found to exceed its ideal gas limit deep in the pion condensed phase, the first account of the violation of this limit in first principles QCD. Finally, we also compute the phase diagram in the temperature — isospin density plane for the first time. Even though the results are not continuum extrapolated and thus not final, the data for all observables will be useful for the benchmarking of effective theories and low-energy models of QCD and are provided in ancillary files for simple reuse.
TCFHs and hidden symmetries of type IIA AdS backgrounds
Authors: Papadopoulos G. , Phillips J. 
Published: July 2023

Abstract
We present the twisted covariant form hierarchies (TCFHs) of warped (massive) IIA AdS backgrounds. As a consequence we demonstrate that all Killing spinor form bilinears satisfy a generalisation of the conformal Killing-Yano equation with respect to the TCFH connections. We also explore some of the properties of TCFHs which include the reduced holonomy of the minimal TCFH connections for generic backgrounds. Furthermore, we investigate the interplay between TCFHs and hidden symmetries of probes propagating on IIA AdS backgrounds. We find that some of the Killing spinor form bilinears of near horizon geometries of a class of IIA intersecting brane configurations are Killing-Yano forms and so generate hidden symmetries for spinning particle probes.
Looking outside the box: a comparative cross-kingdom view on the cell biology of the three major lineages of eukaryotic multicellular life
Authors: Panstruga Ralph , Antonin Wolfram , Lichius Alexander 
Published: July 2023

AbstractMany cell biological facts that can be found in dedicated scientific textbooks are based on findings originally made in humans and/or other mammals, including respective tissue culture systems. They are often presented as if they were universally valid, neglecting that many aspects differ—in part considerably—between the three major kingdoms of multicellular eukaryotic life, comprising animals, plants and fungi. Here, we provide a comparative cross-kingdom view on the basic cell biology across these lineages, highlighting in particular essential differences in cellular structures and processes between phyla. We focus on key dissimilarities in cellular organization, e.g. regarding cell size and shape, the composition of the extracellular matrix, the types of cell–cell junctions, the presence of specific membrane-bound organelles and the organization of the cytoskeleton. We further highlight essential disparities in important cellular processes such as signal transduction, intracellular transport, cell cycle regulation, apoptosis and cytokinesis. Our comprehensive cross-kingdom comparison emphasizes overlaps but also marked differences between the major lineages of the three kingdoms and, thus, adds to a more holistic view of multicellular eukaryotic cell biology.
Exceptionally Cold and Warm Spring Months in Kraków Against the Background of Atmospheric Circulation (1874–2022)
Authors: Bielec-Bąkowska Zuzanna , Twardosz Robert 
Published: July 2023

AbstractIn the changing climate, exceptionally warm (EWMs) and dry spring months are increasingly observed. At the same time, exceptionally cold months (ECMs) are less frequent, although their impact on a warming climate becomes significant. Due to the role that such climatic anomalies play in the environment and their effects on human activity, it is very important to explain the causes of their occurrence. For this reason, in this study, the authors have attempted to determine the circulation conditions favourable to the occurrence of extremely cold (ECM) and warm (EWM) spring months in Kraków in the years 1874–2022. The study used the average temperature of individual spring months (March–May), as well as types of atmospheric circulation and air masses from the daily Calendar of Atmospheric Circulation Types for southern Poland. A distinct increase in spring air temperature (0.181 °C/10 years) and its individual months (0.162–0.191 °C/10 years) was confirmed. It was accompanied by a significant increase in the occurrence of EWM and a decrease in ECM. It was also found that the direction of air advection and the related temperature characteristics of air masses have the greatest impact on the occurrence of exceptionally cold or warm months. A slight positive effect of zonal circulation on the temperature increase at the beginning of the spring season and the advection of air from the south in April and east in May was found. In the case of the coldest months (ECMs), low temperatures most often developed in the presence of advection from the NW-N-NE directions.
Crosstalk between immune checkpoint and DNA damage response inhibitors for radiosensitization of tumors
Authors: Classen Sandra , Petersen Cordula , Borgmann Kerstin 
Published: July 2023

Abstract
Purpose
This review article is intended to provide a perspective overview of potential strategies to overcome radiation resistance of tumors through the combined use of immune checkpoint and DNA repair inhibitors.

Methods
A literature search was conducted in PubMed using the terms (“DNA repair* and DNA damage response* and intracellular immune response* and immune checkpoint inhibition* and radio*”) until January 31, 2023. Articles were manually selected based on their relevance to the topics analyzed.

Results
Modern radiotherapy offers a wide range of options for tumor treatment. Radiation-resistant subpopulations of the tumor pose a particular challenge for complete cure. This is due to the enhanced activation of molecular defense mechanisms that prevent cell death because of DNA damage. Novel approaches to enhance tumor cure are provided by immune checkpoint inhibitors, but their effectiveness, especially in tumors without increased mutational burden, also remains limited. Combining inhibitors of both immune checkpoints and DNA damage response with radiation may be an attractive option to augment existing therapies and is the subject of the data summarized here.

Conclusion
The combination of tested inhibitors of DNA damage and immune responses in preclinical models opens additional attractive options for the radiosensitization of tumors and represents a promising application for future therapeutic approaches.
Hirnabszess als Komplikation bei pulmonaler Manifestation einer HHT
Authors: Müller May Cathleen , Weiler-Normann Christina , Meyer Mathias , Schramm Christoph , Buescher Gustav 
Published: July 2023

ZusammenfassungBei einer 43-jährigen Patientin mit einem komplikativen Verlauf eines Hirnabszesses konnte im Martin Zeitz Centrum für Seltene Erkrankungen die Diagnose „hereditäre hämorrhagische Teleangiektasie“ (HHT) gestellt werden. Ursächlich für den Hirnabszess zeigten sich HHT-typische pulmonale arteriovenöse Malformationen (AVM). Bei Patient:innen mit kryptogenem Hirnabszess sollte regelhaft ein Screening auf pulmonale AVM und HHT durchgeführt werden. Die vorliegende Kasuistik verdeutlicht den hohen Stellenwert der ausführlichen Anamnese sowie die interdisziplinäre Behandlung bei komplexen Verläufen seltener Erkrankungen.