bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting the effects of MDR1 Variants using computational approaches
Authors: Gutman Tal , Tuller Tamir 
Published: September 2023

AbstractP-glycoprotein, encoded by the MDR1 gene, is an ATP-dependent pump that exports various substances out of cells. Its overexpression is related to multi drug resistance in many cancers. Numerous studies explored the effects of MDR1 variants on p-glycoprotein expression and function, and on patient survivability. T1236C, T2677C and T3435C are prevalent MDR1 variants that are the most widely studied, typically in-vitro and in-vivo, with remarkably inconsistent results. In this paper we perform computational, data-driven analyses to assess the effects of these variants using a different approach. We use knowledge of gene expression regulation to elucidate the variants’ mechanism of action. Results indicate that T1236C increases MDR1 levels by 2-fold and is correlated with worse patient prognosis. Additionally, examination of MDR1 folding strength suggests that T3435C potentially modifies co-translational folding. Furthermore, all three variants reside in potential translation bottlenecks and likely cause increased translation rates. These results support several hypotheses suggested by previous studies. To the best of our knowledge, this study is the first to apply a computational approach to examine the effects of MDR1 variants.
Ensitrelvir Fumaric Acid in Patients with SARS-CoV-2: A Retrospective Chart Review
Authors: Yamato Masaya , Kinoshita Masahiro , Miyazawa Shogo , Seki Masayuki , Mizuno Tomoki , Sonoyama Takuhiro 
Published: September 2023

ABSTRACTIntroductionAntivirals with differing mechanisms of action are needed for COVID-19 treatment; remdesivir is mainly used in hospitalized patients, but additional antivirals are needed in this setting. Ensitrelvir, a 3C-like protease inhibitor, received emergency approval in Japan in November 2022, based on evidence of rapid symptom resolution in non-hospitalized patients, but confirmation of its efficacy in hospitalized patients is lacking.Case presentationsThis case series reports outcomes for all patients who received ensitrelvir whilst hospitalized with SARS-CoV-2 infection at Rinku General Medical Center, Japan (November 2022– April 2023). Thirty-two hospitalized patients received five days of ensitrelvir treatment (375/125 mg). Mean age was 73.5 years and most patients had mild COVID-19. Patients exhibited various underlying diseases, most commonly hypertension (78.1%) and chronic kidney disease (25.0%). Seven (21.9%) patients were on hemodialysis. The most common concomitant medications were antihypertensives (59.4%) and corticosteroids (31.2%); two (6.3%) patients were being treated with rituximab; 27 (84.4%) patients had viral persistence following pre-treatment remdesivir failure. Following ensitrelvir treatment, all patients experienced clinical improvement as assessed by the investigator. No ICU admissions or deaths due to COVID-19 occurred. Viral clearance was recorded in 18 (56.3%) patients by day 5 and 25 (78.1%) patients at final measurement. No new safety signals were observed.DiscussionThis case series represents ensitrelvir clinical efficacy in hospitalized patients with SARS-CoV-2 in a real-world setting. Most patients experienced persistent viral shedding despite pre-treatment with antivirals, and most were considered high-risk due to underlying conditions. Despite this, no patients experienced progression of COVID-19 to severe or critical disease, including those who failed prior remdesivir treatment. The antiviral activity of ensitrelvir demonstrated here indicates it is a viable treatment option for SARS-CoV-2 infection in this setting.ConclusionEnsitrelvir was associated with potent antiviral activity and positive clinical outcomes in high-risk, hospitalized patients with various comorbidities.Trial RegistrationUMIN000051300Key Summary PointsWhy carry out this study?Real-world evidence of ensitrelvir for the treatment of COVID-19, especially in inpatient settings, is required.This was a retrospective cohort analysis, consisting of 32 high-risk hospitalized patients with a range of disease severities and comorbidities, including patients who had experienced remdesivir treatment failure.What was learned from the study?All patients experienced clinical improvement following ensitrelvir treatment, without any worsening COVID-19.Viral clearance was documented in 78.1% of patients at final viral measurement.No new safety signals of ensitrelvir were observed in this analysis.
Live virus neutralizing antibodies against pre and post Omicron strains in food and retail workers in Québec, Canada
Authors: Rabezanahary Henintsoa , Gilbert Caroline , Santerre Kim , Scarrone Martina , Gilbert Megan , Thériault Mathieu , Brousseau Nicholas , Masson Jean-François , Pelletier Joelle N. , Boudreau Denis , Trottier Sylvie , Baz Mariana 
Published: September 2023

AbstractObjectivesTo assess the neutralization activity pre and post Omicron BA.1 emergence in a unique cohort of 280 vaccinated restaurant/bar, grocery and hardware store workers in Québec, Canada.MethodsParticipants were recruited during the emergence of Omicron BA.1 variant. The neutralizing activity of participant sera was assessed by microneutralization assay.ResultsSerum neutralizing antibody (NtAb) titers of all participants against the ancestral SARS-CoV-2 strain was comparable with the response against Delta variant, however, their response was significantly reduced against Omicron BA.1, BA2, BA.2.12.1, BA.4 and BA.5. The neutralizing response of each group of workers was similar. Individuals who received 2 doses of vaccine had significantly reduced NtAb titers against all SARS-CoV-2 strains compared to those infected and then vaccinated (≥1 dose), vaccinated (≥2 doses) and then infected, or those who received 3 doses of vaccine. Participants vaccinated with 2 or 3 doses of vaccine and then infected had the highest NtAb titers against all SARS-CoV-2 strains tested.ConclusionWe assessed for the first time the NtAb response in food and retail workers. Individuals infected after ≥2 doses of vaccine had the highest levels of NtAbs against Omicron BA.1, BA.2 and BA.5 variants and might be better protected against reinfection.
GLOBAL PREVALENCE OF DEPRESSION IN CHRONIC KIDNEY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Adejumo Oluseyi Ademola , Edeki Imuetinyan Rahsida , Dapo Oyedepo , Falade Joshua , Yisau Olawale Elijah , Ige Olanrewaju Olumide , Adesida Adedayo Oluwadamilola , Palencia Hansel , Moussa Ayman , Abdulmalik Jibril , Noubiap Jean Jacques , Ekrikpo Udeme Ekpenyong 
Published: September 2023

ABSTRACTBackgroundChronic kidney disease (CKD) is commonly associated with psychosocial problems, especially depression, contributing to poor overall outcomes in CKD patients. Depression has not been given adequate priority in the management of CKD despite its significant adverse impact.ObjectivesThis systematic review and meta-analysis determined the pooled prevalence of clinical depression in the global CKD population and sub-populations.DesignA systematic search of PubMed, African Journals Online (AJOL), and EMBASE was undertaken to identify published articles with relevant data between 1989 and 2022. The pooled prevalence of clinical depression in the global CKD population was determined using random effects meta-analytic techniques.ParticipantsGlobal adult and paediatric CKD populationResultsEligible Sixty-one articles were included in this review, comprising 79,691 CKD patients from 26 countries. The participants’ mean age ranged from 11.0 to 76.3 years. Most (68.9%) of the studies had medium methodological quality. The overall pooled prevalence of depression was 27.6% (95% CI: 23.9–31.5%). Studies using Diagnostic Statistical Manual (DSM), International Classification of Disease, Mini-International Neuropsychiatric Interview and Structured Clinical Interview for DSM disorder returned a pooled prevalence of 31.7%, 39.6%, 23.3%, 25.1%, respectively; p=0.09. There was significant difference in the pooled prevalence of CKD across the various continents; p=0.01.The prevalence of depression was higher among patients on chronic haemodialysis compared to those in pre-dialysis (31.1% versus 18.9%; p=0.02), and among those on hemodialysis compared to peritoneal dialysis (31.9% versus 20.4%; p=0.03). There was no significant difference between adults and children (28.0% versus 15.9%, p=0.17).ConclusionDepression is a common disorder in patients with CKD. The findings of this study have brought to the fore the need for clinicians to make deliberate efforts to evaluate CKD patients for depression, especially those with advanced stages of the disease.The study protocol was registered with PROSPERO (CRD42022382708)Strengths and LimitationsThe pooled prevalence of depression in this study correctly represents the magnitude of the depression in the CKD population because it included only studies where depression was diagnosed clinically.This review involved the global population of both adult and paediatric patients with pre-dialysis and dialytic kidney disease.Only a few studies in this review determined the prevalence of depression in the early stages of CKD.Studies reporting depression prevalence among kidney transplant patients were not included in this review, and the number of studies in the paediatric population was limited.
Uncovering the mosaic evolution of the carnivoran skeletal system
Authors: Law Chris J. , Hlusko Leslea J. , Tseng Z. Jack 
Published: September 2023

AbstractThe diversity of vertebrate skeletons is often attributed to adaptations to distinct ecological factors such as diet, locomotion, and sensory environment. Although the adaptive evolution of skull, appendicular skeleton, and vertebral column is well studied in vertebrates, comprehensive investigations of all skeletal components simultaneously are rarely performed. Consequently, we know little of how modes of evolution differ among skeletal components. Here, we tested if ecological and phylogenetic effects led to distinct modes of evolution among the cranial, appendicular, and vertebral regions in extant carnivoran skeletons. Using multivariate evolutionary models, we found mosaic evolution in which only the mandible, hindlimb, and posterior (i.e., last thoracic and lumbar) vertebrae showed evidence of adaptation towards ecological regimes whereas the remaining skeletal components reflect clade-specific evolutionary shifts. We hypothesize that the decoupled evolution of individual skeletal components may have led to the origination of distinct adaptive zones and morphologies among extant carnivoran families that reflect phylogenetic hierarchies. Overall, our work highlights the importance of examining multiple skeletal components simultaneously in ecomorphological analyses. Ongoing work integrating the fossil and paleoenvironmental record will further clarify deep-time drivers that govern carnivoran diversity we see today and reveal the complexity of evolutionary processes in multicomponent systems.
Plasmodium falciparumpopulations, transmission dynamics and infection origins across Papua New Guinea
Authors: Harrison G.L. Abby , Mehra Somya , Razook Zahra , Tessier Natacha , Lee Stuart , Hetzel Manuel W. , Tavul Livingstone , Laman Moses , Makita Leo , Amato Roberto , Miotto Olivo , Burke Nicholas , Jensen Anne , Kwiatkowski Dominic , Betuela Inoni , Siba Peter M. , Bahlo Melanie , Mueller Ivo , Barry Alyssa E. 
Published: September 2023

ABSTRACTPathogen genomic surveillance demands rapid, low-cost genotyping solutions for tracking infections. Here we use single nucleotide polymorphism (SNP) barcodes to generate practical information for malaria surveillance and control. Using 91Plasmodium falciparumgenomes from three provinces of Papua New Guinea (PNG), we assessed SNP panels with different allele frequency characteristics. A 191 ‘local’ SNP barcode captured similar patterns of population structure evident with 5786 ‘whole genome’ SNPs. Geographically informative SNPs (iSNPs,FST>0.05) show increased population clustering whilst randomly selected SNPs (rSNPs) and SNPs with similar allele frequencies (FST<0.05) amongst different countries (universal, uSNPs) or local PNG populations (balanced, bSNPs) indicated little clustering. SNP panels must be validated in local settings to ensure they capture the diversity and population structure of the target population. Applied to 727P. falciparumisolates from 16 provinces of PNG, the full barcode identified variable transmission dynamics, and eight major sub-populations, as well as the source of a malaria outbreak in a low transmission setting.
Multicentric validation of a Multimorbidity Adjusted Disability Score to stratify depression-related risks using temporal disease maps
Authors: González-Colom Rubèn , Mitra Kangkana , Vela Emili , Gezsi Andras , Paajanen Teemu , Gal Zsofia , Hullam Gabor , Mäkinen Hannu , Nagy Tamas , Kuokkanen Mikko , Piera-Jiménez Jordi , Roca Josep , Antal Peter , Juhasz Gabriella , Cano Isaac 
Published: September 2023

ABSTRACTIn the EU project TRAJECTOME, we used a novel methodology to identify temporal disease maps of depression and highly prevalent co-occurring disease conditions. This information was combined with disability weights established by the Global Burden of Disease Study 2019 to create a depression-related health risk assessment tool, the Multimorbidity Adjusted Disability Score (MADS). MADS was used to stratify over one million cases from three different cohorts and evaluate the impact on utilisation of healthcare resources, mortality, pharmacological burden, healthcare expenditure and multimorbidity progression. Results indicate statistically significant associations between MADS and increased mortality rate (P <.001), heightened healthcare utilization (i.e. emergency room visits P <.001; hospitalizations P <.001; pharmaceutical prescriptions P <.001; total healthcare expenditure P <.001), and a higher risk of disease progression and incidence of new depression-related comorbidities. MADS seems to be a promising approach to predict depression-related health risk and depression’s impact on individuals and healthcare systems, which can be tested in other diseases; nevertheless, clinical validation is still necessary.
Iterative learning data driven strategy for aircraft control system
Authors: Jianhong Wang , Xiaoyong Guo 
Published: September 2023

Purpose
This paper aims to extend the previous contributions about data-driven control in aircraft control system from academy and practice, respectively, combining iteration and learning strategy. More specifically, after returning output signal to input part, and getting one error signal, three kinds of data are measured to design the unknown controller without any information about the unknown plant. Using the main essence of data-driven control, iterative learning idea is introduced together to yield iterative learning data-driven control strategy. To get the optimal data-driven controller, other factors are considered, for example, adaptation, optimization and learning. After reviewing the aircraft control system in detail, the numerical simulation results have demonstrated the efficiency of the proposed iterative learning data-driven control strategy.

Design/methodology/approach
First, considering one closed loop system corresponding to the aircraft control system, data-driven control strategy is used to design the unknown controller without any message about the unknown plant. Second, iterative learning idea is combined with data-driven control to yield iterative learning data-driven control strategy. The optimal data-driven controller is designed by virtue of power spectrum and mathematical optimization. Furthermore, adaptation is tried to combine them together. Third, to achieve the combination with theory and practice, our proposed iterative learning data-driven control is applied into aircraft control system, so that the considered aircraft can fly more promptly.

Findings
A novel iterative learning data-driven strategy is proposed to efficiently achieve the combination with theory and practice. First, iterative learning and data-driven control are combined with each other, being dependent of adaptation and optimization. Second, iterative learning data-driven control is proposed to design the flight controller for the aircraft system. Generally, data-driven control is more wide in our living life, so it is important to introduce other fields to improve the performance of data-driven control.

Originality/value
To the best of the authors’ knowledge, this new paper extends the previous contributions about data-driven control by virtue of iterative learning strategy. Specifically, iteration means that the optimal data-driven controller is solved as one recursive form, being related with one gradient descent direction. This novel iterative learning data-driven control has more advanced properties, coming from data driven and adaptive iteration. Furthermore, it is a new subject on applying data-driven control into the aircraft control system.
The role of CRM implementation in internal capital markets
Authors: Cheng Zhuo June , Min Yinghua , Tian Feng , Xu Sean Xin 
Published: September 2023

Purpose
The purpose of this paper is to investigate how customer relationship management (CRM) implementation affects internal capital allocation efficiency, the efficiency with which a firm allocates its capital across its business segments.

Design/methodology/approach
The authors use a statistical regression method to analyze a sample of 801 unique firms in the USA from COMPUSTAT and the Computer Intelligence database. This analysis examines the relation between CRM implementation and internal capital allocation efficiency and identifies the conditions under which firms benefit more from CRM implementation. They also use instrumental variables (IVs) to address endogenous concerns with a two-stage least squares (2SLS) model.

Findings
The authors find that CRM implementation is positively related to internal capital allocation efficiency. The results are robust to the 2SLS analysis with IVs. This positive relation is more pronounced for firms with effective internal control and for those operating in highly competitive markets.

Practical implications
The research implies that that CRM can have a significant cross-functional effect on corporate financing and budgeting. This also suggests that when chief marketing officers plan marketing initiatives and implement CRM, they should communicate to chief financial officers not only the direct effect but also the indirect strategic benefits of such initiatives to a firm.

Originality/value
The authors reveal a previously overlooked aspect of marketing accountability by suggesting marketing’s impact on internal capital markets. They also enrich the body of literature on CRM benefits by showing a cross-functional benefit from marketing to finance (or capital allocation).
Searching for alternative health and social care integration measurement tools – a rapid review of the existing systematic models
Authors: Tikkanen Samuli , Räsänen Pekka , Sinervo Timo , Keskimäki Ilmo , Sahlström Merja , Pesonen Tiina , Tiirinki Hanna 
Published: September 2023

PurposeHealth care integration is crucial in improving service equality and patient outcomes. However, measuring integration between the health and social care sectors remains challenging. This article aims to review existing systematic models to identify alternative health and social care integration measurement tools. The review focuses on models that involve systematic planning and long-term cooperation across different organizational sectors.Design/methodology/approachThe study examines various dimensions and elements of integration, including process, outcome and structural measures. It compares different tools used to measure social and health care integration, such as the Rainbow model, Balanced Scorecard (BSC) Scorecard, PRISMA, SCIROCCO, integRATE, health-data simulation (HSIM) and the model developed by Åhgren and Axelsson. The analysis includes both empirical studies and theoretical frameworks.FindingsThe findings highlight the importance of standardized measurement methods to assess the impact of integration initiatives on patient outcomes, healthcare costs and the quality of care.Originality/valueThe review contributes to the ongoing discourse on social and health care integration, particularly in the Nordic context. The results can inform social and healthcare providers, policymakers and researchers in evaluating and improving integration initiatives.
Performance implications of financial resource allocation in new hiring: the case of major league baseball
Authors: Shin Ho Wook , Cho Sungho , Lee Jong Kwan 
Published: September 2023

PurposeIntegrating the resource-based view (RBV) with pay dispersion research, the authors examine how the allocation of resources between hiring new employees and compensating current employees, as well as the allocation of resources among new employees, affects organizational performance.Design/methodology/approachThe authors use panel data on Major League Baseball teams. The authors also use system generalized method of moments (GMM) estimations to control for the impact of past performance on current performance, unobserved individual heterogeneity and omitted variable bias.FindingsThe authors find that the larger the portion of the human resources (HR) budget allocated to hiring new employees, the poorer organizational performance becomes unless the focal organization has already significantly underperformed. The authors also find that pay concentration among new employees has a positive impact on organizational performance unless the focal organization has already significantly overperformed.Originality/valueThis study extends RBV research by examining how resource allocation patterns affect organizational performance, which has rarely been studied. Moreover, by showing the organizational context's significant effect on the outcome of financial allocation for resource acquisition, this study extends both the RBV research and the pay dispersion research.
Driving sustained work engagement: moderating role of leadership and organizational support for remote work
Authors: Deepa R. , Dharshini J. Juvala 
Published: September 2023

Purpose
This study aims to understand the impact of key resources on work engagement while working from home (WFH). Social support is divided into the support provided at home and leadership and organizational support (LOS) provided externally. Thus, the study contends that while WFH employees invest in internal resources, they seek validation, care and assurance from external resources. Previous studies' limitations were addressed by considering LOS as an external resource that strengthens the relationship between internal resources and work engagement.

Design/methodology/approach
Survey research (n = 244) was undertaken, and the interaction effect between LOS and the other resources like flexibility, work support and the home environment was empirically validated using PROCESS macro.

Findings
The interaction effects between LOS and the internal resources were positive, which suggests that LOS helps mitigate the stress associated with remote working and results in positive work engagement.

Originality/value
The study delineates LOS as an external resource that augments the effect of internal resources on work engagement, which impacts work engagement. In research, significantly less effort has been expended on studying the effect of the home domain on work engagement, which was also the focus of this study. Future research can look at other factors that impact work engagement, especially in a remote work setting.