bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN DUKUNGAN SOSIAL KELOMPOK SEBAYA DENGAN TINGKAT INFORMASI KEPATUHAN MINUM OBAT ANTIRETROVIRAL PADA ODHA DI JOMBANG CARE CENTER PLUS
Authors: LOPES RYANA DUTA , DARAMATASIA WIRA , JAYANTI NICKY DANUR 
Published: July 2023

In lifelong anti-retroviral (ARV) treatment, the resistance of People With HIV AIDS (PLWHA) is very important because the human immunodeficiency virus (HIV), attacking or infecting T lymphocytes, causes a decrease in the immune system. As a result, it causes physical, psychological, independence, social, environmental, and spiritual problems. One factor that can affect PLWHA compliance in undergoing ARV treatment therapy is the role of peer support groups. The degree of PLWHA compliance with ARV can reduce the rate of pain and even death from HIV. Objective: The aim of this study is to evaluate the relationship between the social support provided to peer groups with the level of information compliance with ARV on ODHIV in the Equal Support Group of Jombang Care Center Plus. Method: This study is a cross-sectional analytical survey. The sample consists of 30 ODHIVs, with urposive sampling techniques. The social support of peer groups and level of information adherenced ARV measured using quizzes. The statistical test used is the somers'd test. Results: The results of the study showed that the social support of peer groups with the level of ARV information adherence to PLWHA was positively correlated with moderate strength (p-value 0.003 and correlation coefficient 0.397) Conclusion: There was a relationship between peer-group social support and the level of information adherence on ARV at PLWHA at Jombang Care Center Plus.
FUNGSI DAN NILAI PENDIDIKAN DALAM WAYANG GUNG ANGGADA BALIK
Authors: Dewi Rukmini Sulistyawati  , Suwarjiya  , Purnama Asri Gita Kinanthi 
Published: July 2023

Penelitian ini dilakukan pada grup Wayang Gung Pasopati yang ada di desa Gudang Hirang, Sungai Tabuk, Kalimantan Selatan. Dari beberapa grup Wayang Gung yang ada di Kalimantan Selatan, grup Pasopati relatif masih aktif meskipun sangat jarang tampil dikarenakan sepinya peminat. Grup ini terbentuk pada 04 Maret tahun 1993. Seperti kesenian tradisional di Indonesia yang lain, didalam Wayang Gung mengandung nilai dan memiliki fungsi tersendiri bagi masyarakat. Beberapa waktu yang lalu grup Pasopati mendapat kesempatan untuk tampil di Taman Budaya secara Virtual dengan membawakan cerita Anggada Balik. Hal ini merupakan kesempatan yang sangat baik untuk mengkaji dan menengok kembali fungsi dan nilai-nilai yang terkandung di dalam kesenian tradisional tersebut. Penelitian ini bertujuan untuk mengetahui dan memberikan gambaran secara deskriptif, 1)Fungsi- fungsi dari pertunjukan teater tradisi Wayang Gung di masyarakat. 2) Aspek-aspek pertunjukan teater tradisi Wayang Gung yang mengandung nilai pendidikan. Metode yang digunakan dalam penelitian adalah deskriptif kualitatif. Berdasarkan pengumpulan dan analisis data didapat hasil sebagai berikut, pertunjukan Virtual Wayang Gung Anggada Balik memiliki fungsi sebagai hiburan, media pendidikan, dan estetik. Di dalamnya mengandung nilai pendidikan religius, nilai pendidikan moral, dan nilai pendidikan sosial. Nilai-nilai tersebut terdapat pada dialog dan adegan yang dibawakan.
Kata kunci: Wayang Gung, Nilai pendidikan, Fungsi, Anggada Balik, Grup Pasopati
PROSES PENCIPTAAN DAN STRUKTUR TARI UDAR GELUNG
Authors: Nugraha Saefurridjal Angga , Rasidin Dindin , Fajaria Ria Dewi 
Published: July 2023

Abstrak: Karya tari ini diadopsi dari sebuah kesenian Ibing Penca Sobrah di salah satu perguruan tertua tanah Pasundan yaitu Panglipur, yang diidentikkan dengan sosok guru besar perguruan tersebut yaitu Rd. Hj. Enny Rukmini Sekarningrat. Terkenal dengan peran sobrah(rambut tambahan)yang digunakan sebagai senjata melawan musuh. Kata Udar dan Gelung berasal dari bahasa Sunda, Udar berarti melepas, gelung artinya ikatan rambut yang melingkar, Udar Gelung berarti melepas ikatan rambut. Namun, pada karya ini memiliki arti‚ lepasnya harga diri Wanoja oleh seorang Jawara yang sombong. Teori penciptaan karya tari ini menggunakan pendekatan objektif dan subjektif, berfokus pada hasil karya kreasi seorang koreografer yang diungkapkan oleh penari. Semua proses tersebut melampaui metode eksplorasi, komposisi dan evaluasi. Jenis koreografi adalah kelompok, yang dibagi dalam tiga pengadegan dengan jumlah penari sebanyak enam orang penari laki-laki dan satu penari perempuan. Proses penciptaan karya dituangkan dalam konsep garap tradisi dengan struktur dramatik dan bersumber dari gerak tradisi khas pencak silat/ Ibing Penca. Adapun pesan moral yang diangkat ialah segala sesuatu selalu akan ada timbal baliknya dan apa yang kita perbuat, itu yang kita dapatkan.
Kata Kunci: Udar Gelung, Ibing Penca Sobrah, Wanoja.
TARI LANGKAH MAMBUNGA: STILISASI GERAK KUNTAU
Authors: Muzdalifah Safana , Wijaya Andi , Sulistyawati Dewi Rukmini 
Published: July 2023

Kuntau sebagai seni bela diri tradisional yang berada di Hulu Sungai Selatan menjadi salah satu budaya yang memiliki nilai luhur. Tari kreasi Langkah Mambunga digarap sanggar Karamunting (2018) dengan inspirasi dari Kuntau.Tujuan penelitian ini untuk mendeskripsikan stilisasi gerak kuntau dalam tari Langkah Mambunga dan mendeskripsikan bentuk penyajiannya. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan teknik pengumpulan data wawancara, observasi, studi pustaka, dan dokumentasi. Data yang didapat kemudian melalui tahapan analisis dan penarikan kesimpulan. Hasil penelitian ini adalah stilisasi dilakukan berdasarkan volume, dimensi, dan level, terdapat 4 jurus kuntau dan 8 gerak ragam yang sudah dihaluskan dan disusun menjadi tari Langkah Mambunga. Hal ini berlatar pada alur cerita yang terbagi atas 3 adegan tentang muda-mudi yang sedang belajar Kuntau hingga batamat kuntau sebagai budaya lokal. Penari berjumlah 13 orang yang terdiri dari 10 perempuan dan 3 laki-laki. Desain lantai yang terbentuk sejumlah 17 desain dengan iringan musik yang identik dengan sarunai pada kuntau namun dipadukan dengan beberapa alat musik lainnya. Tongkat, nyiru, parapin, lawing sakiping(simbol sebuah gelanggang)dan kain digunakan sebagai properti tari. Tata cahaya berfungsi sebagai penerang dan penguatan suasana di setiap adegan, sedangkan tempat pertunjukan berupa panggung procenium dengan kriteria ukuran yang cukup luas.
Kata Kunci: Tari, Langkah Mambunga, Stilisasi, Kuntau
Optimasi Sistem Photovoltaik Menggunakan Cuk Converter Dengan MPPT Incremental Conductance
Authors: Wirawan Dewantara Bagus , Dewatama Denda , Yulianto Yulianto 
Published: July 2023

DC-DC Converter merupakan sebuah device yang mengubah atau mengkonversi energi listrik dari satu nilai tegangan ke nilai tegangan lainnya dengan cara menaikkan atau menurunkan tegangan sesuai dengan keluaran yang diinginkan. Salah satu topologi dari DC-DC Converter adalah Cuk Converter. Cuk Converter dipilih karena memiliki arus yang kontinyu pada sisi input maupun output. Untuk mendapatkan nilai daya yang optimum panel surya dibutuhkan metode MPPT (Maximum Power Point Tracker) pada DC-DC Converter. Algoritma yang digunakan pada penelitian ini adalah Incremental Conductance (IC). Keluaran algoritma ini adalah berupa duty cycle yang digunakan sebagai switching mosfet pada converter. Metode IC dipilih karena dapat menghasilkan daya keluaran dan kecepatan tracker MPP (Maximum Power Point) yang lebih tinggi disbanding metode P&O (Perturb & Observe). Sistem ini diuji dengan panel surya 100 Wp. Dari hasil pengujian system menggunakan MPPT didapatkan daya keluaran tertinggi saat intensitas cahaya matahari sebesar 198000 Lux yaitu 37,9W dengan effisiensi sebesar 88 persen.
Novel patch biomaterial treatment for colon diverticulosis in swine model
Authors: Guo Xiaomei , Patel Bhavesh , Han Ling , Van Alstine William G. , Noblet Jillian N. , Chambers Sean D. , Kassab Ghassan S. 
Published: July 2023

Current leading managements for diverticular disease cannot prevent the recurrence of diverticulitis, bleeding and/or other complications. There is an immediate need for developing new minimal invasive therapeutic strategies to prevent and treat this disease. Through a biomechanical analysis of porcine colon with diverticular lesions, we proposed a novel adhesive patch concept aiming at mechanical reconstruction of the diseased colon wall. This study aims to evaluate the surgical feasibility (safety and efficacy) of pulmonary visceral pleura (PVP) patch therapy using a pig model of diverticulosis. Six female Yucatan miniature pigs underwent collagenase injection (CI) for the development of diverticular lesions. The lesions in each animal either received patch implantation (treated group, n = 40 for 6 pigs) or left intact (untreated group, n = 44 for 6 pigs). The normal colonic wall in each animal received patch implantation at two spots to serve as control (n = 12 for 6 pigs). After 3 months of observation, the performance and safety of the patch treatment were evaluated through macroscopic and histological examination. We found that 95% of pouch-like herniation of the mucosa was prevented from the colon wall with the treatment. The pouch diameter was significantly reduced in the treated group as compared to the untreated group (p &lt; 0.001). The patch application caused a significant increase in the levels of collagen of the colon tissue as compared to the untreated and control groups (p &lt; 0.001). No difference was found in the lymphocyte and macrophage inflammatory infiltrate between the groups. Our results suggest that patch treatment efficiently inhibits the diverticular pouch deformation and promotes the healing of the colon wall with a normal inflammatory response, which may minimize the risk of diverticulosis reoccurrence and complications over time.
Encephalitis and myositis caused by Trachipleistophora hominis diagnosed by metagenomic next-generation sequencing—a case report
Authors: Zheng Haipeng , Tan Ying , Chen Xudan , Chen Jinfeng , Li Linghua , Wang Jian 
Published: July 2023

BackgroundMyositis is the main manifestation of Trachipleistophora hominis (T. hominis) infection and other microsporidians infection in immunocompromised patients. Clinical differential diagnosis of different microsporidians can be challenging, as the standard technique to distinguish various microsporidia species, transmission electron microscopy (TEM), is time-consuming and relies on equipment and experienced staffs who can perform the test and interpret the results.Case presentationWe report a 37-year-old Chinese man with acquired immune deficiency syndrome (AIDS) developed headache and muscle pain in the extremities. Tramadol was used to relieve his pain. Infectious lesions in his brain were detected by cerebral magnetic resonance imaging (MRI). Oval-shaped pathogens was observed by biopsy of right gastrocnemius. Finally, T. hominis was identified by metagenomic next-generation sequencing (mNGS) in the gastrocnemius tissue and cerebrospinal fluid. After a 12-week course of antifungal treatment and antiretroviral therapy, the patient recovered from the encephalitis and myositis caused by T. hominis.ConclusionThis report described the diagnosis and treatment of the first case of encephalitis caused by T. hominis. And mNGS is recommended for the rapid diagnosis of uncommon pathogens.
A study of factors influencing long-term glycemic variability in patients with type 2 diabetes: a structural equation modeling approach
Authors: Gan Yuqin , Chen Mengjie , Kong Laixi , Wu Juan , Pu Ying , Wang Xiaoxia , Zhou Jian , Fan Xinxin , Xiong Zhenzhen , Qi Hong 
Published: July 2023

AimThe present study aims to utilize structural equation modeling (SEM) to investigate the factors impacting long-term glycemic variability among patients afflicted with type 2 diabetes.MethodThe present investigation is a retrospective cohort study that involved the collection of data on patients with type 2 diabetes mellitus who received care at a hospital located in Chengdu, Sichuan Province, over a period spanning from January 1, 2013, to October 30, 2022. Inclusion criteria required patients to have had at least three laboratory test results available. Pertinent patient-related information encompassing general demographic characteristics and biochemical indicators was gathered. Variability in the dataset was defined by standard deviation (SD) and coefficient of variation (CV), with glycosylated hemoglobin variation also considering variability score (HVS). Linear regression analysis was employed to establish the structural equation models for statistically significant influences on long-term glycemic variability. Structural equation modeling was employed to analyze effects and pathways.ResultsDiabetes outpatient special disease management, uric acid variability, mean triglyceride levels, mean total cholesterol levels, total cholesterol variability, LDL variability, baseline glycated hemoglobin, and recent glycated hemoglobin were identified as significant factors influencing long-term glycemic variability. The overall fit of the structural equation model was found to be satisfactory and it was able to capture the relationship between outpatient special disease management, biochemical indicators, and glycated hemoglobin variability. According to the total effect statistics, baseline glycated hemoglobin and total cholesterol levels exhibited the strongest impact on glycated hemoglobin variability.ConclusionThe factors that have a significant impact on the variation of glycosylated hemoglobin include glycosylated hemoglobin itself, lipids, uric acid, and outpatient special disease management for diabetes. The identification and management of these associated factors can potentially mitigate long-term glycemic variability, thereby delaying the onset of complications and enhancing patients’ quality of life.
Characterizing subsidence in used and restored peatland with Sentinel SAR data
Authors: Tarigan Suria , Kristanto Yudha , Utomo Waluyo Y. 
Published: July 2023

Peatland is a fragile ecosystem in the tropical region which is prone to subsidence. Until now, there is still lack of procedure to rapidly assess a tropical peatland subsidence in a large area. Our objective was to compare subsidence in a used and restored zone in a peatland hydrological unit using synthetic aperture radar data from Sentinel-1A products (SAR data) in South Sumatra, Indonesia from the period of 2014–2021. The subsidence rate of used peatland estimated by the D-InSAR procedure were in the range of 28–80 cm year−1 in the early period of its utilization and becoming less for the consecutive year (16–48 cm year−1). Meanwhile, the subsidence rate based on the field surveys was in the range of 4–50 cm year−1 in the early period of peatland utilization. The subsidence rate in the used peatland zone (agriculture and plantations) was higher than that in the restoration zone for all SAR data pairs used in our study. The SAR data is a potential tool for the assessment, monitoring and differentiating subsidence rates among different peatland uses in a large area. This tool will help the Directorate of Peat Ecosystem Degradation Control, Directorate General of Environmental Pollution and Degradation Control, and Ministry of Environment and Forestry to plan for better peatland management and restoration.
Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis
Authors: Shu Jianfeng , Jiang Jinni , Zhao Guofang 
Published: July 2023

BackgroundLung adenocarcinoma (LUAD) as a frequent type of lung cancer has a 5-year overall survival rate of lower than 20% among patients with advanced lung cancer. This study aims to construct a risk model to guide immunotherapy in LUAD patients effectively.Materials and methodsLUAD Bulk RNA-seq data for the construction of a model, single-cell RNA sequencing (scRNA-seq) data (GSE203360) for cell cluster analysis, and microarray data (GSE31210) for validation were collected from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. We used the Seurat R package to filter and process scRNA-seq data. Sample clustering was performed in the ConsensusClusterPlus R package. Differentially expressed genes (DEGs) between two groups were mined by the Limma R package. MCP-counter, CIBERSORT, ssGSEA, and ESTIMATE were employed to evaluate immune characteristics. Stepwise multivariate analysis, Univariate Cox analysis, and Lasso regression analysis were conducted to identify key prognostic genes and were used to construct the risk model. Key prognostic gene expressions were explored by RT-qPCR and Western blot assay.ResultsA total of 27 immune cell marker genes associated with prognosis were identified for subtyping LUAD samples into clusters C3, C2, and C1. C1 had the longest overall survival and highest immune infiltration among them, followed by C2 and C3. Oncogenic pathways such as VEGF, EFGR, and MAPK were more activated in C3 compared to the other two clusters. Based on the DEGs among clusters, we confirmed seven key prognostic genes including CPA3, S100P, PTTG1, LOXL2, MELTF, PKP2, and TMPRSS11E. Two risk groups defined by the seven-gene risk model presented distinct responses to immunotherapy and chemotherapy, immune infiltration, and prognosis. The mRNA and protein level of CPA3 was decreased, while the remaining six gene levels were increased in clinical tumor tissues.ConclusionImmune cell markers are effective in clustering LUAD samples into different subtypes, and they play important roles in regulating the immune microenvironment and cancer development. In addition, the seven-gene risk model may serve as a guide for assisting in personalized treatment in LUAD patients.
Efficacy and safety of immune checkpoint inhibitors combined with chemotherapy as first-line treatment for extensive-stage small cell lung cancer: a meta-analysis based on mixed-effect models
Authors: Zheng Jianqing , Deng Yujie , Huang Bifen , Chen Xiaohui 
Published: July 2023

BackgroundExtensive-stage small cell lung cancer (ES-SCLC) is a highly invasive and fatal disease with limited therapeutic options and poor prognosis. Our study aims to systematically evaluate the efficacy and safety of immune checkpoint inhibitors combined with chemotherapy (ICIs+ChT) vs. chemotherapy alone (ChT) in the first-line treatment of ES-SCLC.MethodsA literature search was performed for randomized controlled trials (RCTs) related to “ICIs+ChT” vs. “ChT” in the first-line treatment of ES-SCLC in PubMed, Cochrane Library, Embase, CNKI, and other databases. RevMan 5.4 software was used to perform meta-analyses with hazard ratio (HR) and relative risk (RR). SAS 9.4 software was applied to conduct a mixed-effect model meta-analysis of the survival outcomes and draw survival curves.ResultsA total of 2,638 patients with ES-SCLC from 6 RCTs were included, of which 1,341 patients received “ICIs+ChT” and 1,297 received ChT. Based on the meta-analysis results provided by the mixed-effect model, patients receiving the “ICIs+ChT” regimen had a significantly longer overall survival (OS, HR = 0.800, 95% CI = 0.731–0.876, P &lt; 0.001) and progression-free survival (PFS, HR = 0.815, 95% CI = 0.757–0.878, P &lt;0.001) in comparison to those receiving ChT only. Compared with ChT, “ICIs+ChT” did neither improve the objective response rate (ORR, RR = 1.06, 95% CI = 1.00–1.12, P = 0.06) nor did it improve the disease control rate (DCR, RR = 0.97, 95% CI = 0.92–1.03, P = 0.35). Although the incidence of grade 3 to 5 treatment-related adverse events (trAEs) in the “ICIs+ChT” subgroup did not increase (RR = 1.16, 95% CI = 0.97–1.39, P = 0.11), the incidence of grade 3 to 5 immune-related adverse events (irAEs) increased significantly (RR = 4.29, 95% CI = 1.73–10.61, P &lt; 0.00001).ConclusionICIs+ChT regimen could significantly prolong OS and PFS in patients with ES-SCLC compared with ChT alone. Although the incidence of irAEs in “ICIs+ChT” is higher than that in the “ChT” subgroup, the incidence of trAEs is similar within the two subgroups. ICIs combined with chemotherapy demonstrated a good choice as first-line treatment for ES-SCLC.Systematic review registrationPROSPERO, identifier: CRD42022348496.
Bioinformatics-based screening of key genes for transformation of tyrosine kinase inhibitor-resistant lung adenocarcinoma to small cell lung cancer
Authors: Zhang Ying , Chen Qiang , Huang Ting , Zhu Di , Lu Yuanzhi 
Published: July 2023

PurposeLung adenocarcinoma (LUAD) is a common type of lung cancer. Cancer in a small number of patients with EGFR mutations will transform from LUAD to small cell lung cancer (SCLC) during epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapiesr. The purpose of the present study was to identify the core genes related to the transformation of LUAD into SCLC and to explore the associated molecular mechanisms.MethodsGSE29016, GSE1037, GSE6044 and GSE40275 mRNA microarray datasets from Gene Expression Omnibus (GEO) were analyzed to obtain differentially expressed genes (DEGs) between LUAD and SCLC tissues, and the results were used for network analysis of protein–protein interactions (PPIs). After identifying the hub gene by STRING and Cytoscape platform, we explored the relationship between hub genes and the occurrence and development of SCLC. Finally, the obtained hub genes were validated in treated LUAD cells.ResultsA total of 41 DEGs were obtained, four hub genes (EZH2, NUSAP1, TTK and UBE2C) were identified, and related prognostic information was obtained. The coexpressed genes of the hub gene set were further screened, and the analysis identified many genes related to the cell cycle. Subsequently, LUAD cell models with TP53 and RB1 inactivation and overexpression of ASCL1 were constructed, and then the expression of hub genes was detected, the results showed that the four hub genes were all elevated in the established cell model.ConclusionEZH2, NUSAP1, TTK and UBE2C may affect the transformation of LUAD to SCLC and represent new candidate molecular markers for the occurrence and development of SCLC.