bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in maternal heart rate in delayed post-partum preeclampsia
Authors: Ravid Dorit , Ovadia Michal , Asali Aula , Nisim Shlomo , Gershnabel Sivan Farladansky , Biron-Shental Tal , Weitzner Omer 
Published: March 2023

Abstract
Aim
Delayed-onset postpartum preeclampsia (PET) is defined as a new diagnosis of preeclampsia presenting 48 h to 6 weeks postpartum. This disorder is infrequent and associated with a higher incidence of complications as compared to antepartum PET. There seems to be a need to further characterize this disorder. The aim of the study was to investigate the difference of maternal heart rate in women with delayed onset postpartum preeclampsia as compared to healthy controls.

Methods
The medical files of all women who were readmitted with delayed onset postpartum preeclampsia during 2014–2020 were reviewed. Data on maternal physiological characteristics were compared to healthy control group of women at the same post-partum day, with uncomplicated pregnancies.

Results
Included 45 women with the diagnosis of delayed onset of preeclampsia at 6.3 ± 2.86 post-partum day. As compared to controls (n = 49), women with delayed post-partum were older, 34.6 ± 5.4 vs. 32.3 ± 4.7 years, p = 0.003. There were no differences between groups regarding maternal gravidity, parity, BMI (kg/m2) or Hb level at delivery day. Women with delayed post-partum preeclampsia had lower mean pulse rate as compared to controls, 58 ± 15 bpm vs. 83 ± 11.6 bpm, respectively, P < 0.0001. Only 17% of the women in the delayed onset group had pulse rate above 70 bpm as compared to 83% in the control group.

Conclusions
Maternal low heart rate in cases with delayed onset of post-partum preeclampsia is an important clinical characteristic that may reflect baroreceptors response to maternal hypertension.
Anterior gradient 2 induces resistance to sorafenib via endoplasmic reticulum stress regulation in hepatocellular carcinoma
Authors: Tsai Hung-Wen , Chen Yi-Li , Wang Chun-I , Hsieh Ching‑Chuan , Lin Yang-Hsiang , Chu Pei-Ming , Wu Yuh-Harn , Huang Yi-Ching , Chen Cheng-Yi 
Published: March 2023

Abstract
Background
Hepatocellular carcinoma (HCC) accounts for almost 80% of all liver cancer cases and is the sixth most common cancer and the second most common cause of cancer-related death worldwide. The survival rate of sorafenib-treated advanced HCC patients is still unsatisfactory. Unfortunately, no useful biomarkers have been verified to predict sorafenib efficacy in HCC.

Results
We assessed a sorafenib resistance-related microarray dataset and found that anterior gradient 2 (AGR2) is highly associated with overall and recurrence-free survival and with several clinical parameters in HCC. However, the mechanisms underlying the role of AGR2 in sorafenib resistance and HCC progression remain unknown. We found that sorafenib induces AGR2 secretion via posttranslational modification and that AGR2 plays a critical role in sorafenib-regulated cell viability and endoplasmic reticulum (ER) stress and induces apoptosis in sorafenib-sensitive cells. In sorafenib-sensitive cells, sorafenib downregulates intracellular AGR2 and conversely induces AGR2 secretion, which suppresses its regulation of ER stress and cell survival. In contrast, AGR2 is highly intracellularly expressed in sorafenib-resistant cells, which supports ER homeostasis and cell survival. We suggest that AGR2 regulates ER stress to influence HCC progression and sorafenib resistance.

Conclusions
This is the first study to report that AGR2 can modulate ER homeostasis via the IRE1α-XBP1 cascade to regulate HCC progression and sorafenib resistance. Elucidation of the predictive value of AGR2 and its molecular and cellular mechanisms in sorafenib resistance could provide additional options for HCC treatment.
Glofitamab therapy for diffuse large B cell lymphoma: latest updates from the 2022 ASH Annual Meeting
Authors: Wang Chaoyu , Liu Yao 
Published: March 2023

AbstractOver one-third of B cell lymphomas are not effectively treated by R-CHOP chemotherapy. When lymphoma relapses or is refractory, the prognosis becomes very poor. Due to this fact, there is an urgent and clear requirement for a more effective, novel treatment option. Glofitamab is a CD20xCD3 T-cell-engaging, bispecific antibody capable of recruiting T cells to tumor cells. We have summarized several of the latest reports on glofitamab use in B cell lymphoma therapy from the 2022 ASH Annual Meeting (ASH2022).
The resonance fluorescence cascade of a laser-excited two-level atom
Authors: Reynaud Serge 
Published: March 2023

AbstractThe cascade of fluorescence photons by a two-level atom excited by coherent laser light is reviewed. The discussion emphasizes the random nature of resonance fluorescence and uses the distribution of delays between two successively emitted photons as the primary characterization of the process. Other characterizations such as photon counting and photon correlation are deduced.
SETD2 non genomic loss of function in advanced systemic mastocytosis is mediated by an Aurora kinase A/MDM2 axis and can be therapeutically targeted
Authors: Mancini Manuela , Monaldi Cecilia , De Santis Sara , Papayannidis Cristina , Rondoni Michela , Sartor Chiara , Bruno Samantha , Pagano Livio , Criscuolo Marianna , Zanotti Roberta , Bonifacio Massimiliano , Tosi Patrizia , Arock Michel , Valent Peter , Cavo Michele , Soverini Simona 
Published: March 2023

Abstract
Background
The SETD2 tumor suppressor gene encodes a histone methyltransferase that safeguards transcription fidelity and genomic integrity via trimethylation of histone H3 lysine 36 (H3K36Me3). SETD2 loss of function has been observed in solid and hematologic malignancies. We have recently reported that most patients with advanced systemic mastocytosis (AdvSM) and some with indolent or smoldering SM display H3K36Me3 deficiency as a result of a reversible loss of SETD2 due to reduced protein stability.

Methods
Experiments were conducted in SETD2-proficient (ROSAKIT D816V) and -deficient (HMC-1.2) cell lines and in primary cells from patients with various SM subtypes. A short interfering RNA approach was used to silence SETD2 (in ROSAKIT D816V cells), MDM2 and AURKA (in HMC-1.2 cells). Protein expression and post-translational modifications were assessed by WB and immunoblotting. Protein interactions were tested by using co-immunoprecipitation. Apoptotic cell death was evaluated by flow cytometry after annexin V and propidium iodide staining, respectively. Drug cytotoxicity in in vitro experiments was evaluated by clonogenic assays.

Results
Here, we show that the proteasome inhibitors suppress cell growth and induce apoptosis in neoplastic mast cells by promoting SETD2/H3K36Me3 re-expression. Moreover, we found that Aurora kinase A and MDM2 are implicated in SETD2 loss of function in AdvSM. In line with this observation, direct or indirect targeting of Aurora kinase A with alisertib or volasertib induced reduction of clonogenic potential and apoptosis in human mast cell lines and primary neoplastic cells from patients with AdvSM. Efficacy of Aurora A or proteasome inhibitors was comparable to that of the KIT inhibitor avapritinib. Moreover, combination of alisertib (Aurora A inhibitor) or bortezomib (proteasome inhibitor) with avapritinib allowed to use lower doses of each drug to achieve comparable cytotoxic effects.

Conclusions
Our mechanistic insights into SETD2 non-genomic loss of function in AdvSM highlight the potential value of novel therapeutic targets and agents for the treatment of patients who fail or do not tolerate midostaurin or avapritinib.
A facilitated social innovation: stakeholder groups using Plan-Do-Study-Act cycles for perinatal health across levels of the health system in Cao Bang province, Vietnam
Authors: Bergström Anna , Hoa Dinh Phuong , Nga Nguyen Thu , Hoa Trieu , Tu Tran Thanh , Lien Pham Thi Lan , Trang Tran , Wallin Lars , Persson Lars-Åke , Eriksson Leif 
Published: March 2023

Abstract
Background
Universal coverage of evidence-based interventions for perinatal health, often part of evidence-based guidelines, could prevent most perinatal deaths, particularly if entire communities were engaged in the implementation. Social innovations may provide creative solutions to the implementation of evidence-based guidelines, but successful use of social innovations relies on the engagement of communities and health system actors. This proof-of-concept study aimed to assess whether an earlier successful social innovation for improved neonatal survival that employed regular facilitated Plan-Do-Study-Act meetings on the commune level was feasible and acceptable when implemented on multiple levels of the health system (52 health units) and resulted in actions with plausibly favourable effects on perinatal health and survival in Cao Bang province, northern Vietnam.

Methods
The Integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework guided the implementation and evaluation of the Perinatal Knowledge-Into-Practice (PeriKIP) project. Data collection included facilitators’ diaries, health workers’ knowledge on perinatal care, structured observations of antenatal care, focus group discussions with facilitators, their mentors and representatives of different actors of the initiated stakeholder groups and an individual interview with the Reproductive Health Centre director. Clinical experts assessed the relevance of the identified problems and actions taken based on facilitators’ diaries. Descriptive statistics included proportions, means, and t-tests for the knowledge assessment and observations. Qualitative data were analysed by content analysis.

Results
The social innovation resulted in the identification of about 500 relevant problems. Also, 75% of planned actions to overcome prioritised problems were undertaken, results presented and a plan for new actions to achieve the group’s goals to enhance perinatal health. The facilitators had significant roles, ensuring that the stakeholder groups were established based on principles of mutual respect. Overall, the knowledge of perinatal health and performance of antenatal care improved over the intervention period.

Conclusions
The establishment of facilitated local stakeholder groups can remedy the need for tailored interventions and grassroots involvement in perinatal health and provide a scalable structure for focused efforts to reduce preventable deaths and promote health and well-being.
Drug and Therapeutics Committee (DTC) evolvement and expanded scope in Ethiopia
Authors: Seyoum Habtamu , Feleke Zinabie , Bikila Dinkineh , Yaregal Alebel , Demisie Amsalu , Ali Seid , Fisseha Salem , Abebe Yigeremu , Battu Audrey , Lam Felix , Bayisa Regasa 
Published: March 2023

As a key partner of Ministry of Health (MOH) Ethiopia, The Clinton Health Access Initiative (CHAI) had been implementing the Child Survival Project (CSP) since October 2015. Strengthening DTC was one of its focuses to improve overall supply chain management (SCM). The objective of this study are to review the evolution of DTCs in Ethiopia from their early years to current practice and identify the major driving and hindering factors for their functionality. A descriptive mixed study design was employed. The study made use of qualitative data supplemented with quantitative data, generated from both primary and secondary sources through key informant interviews and desk review methods. DTCs were introduced in Ethiopia in the early 1980s. The mandate of DTCs has been given to four different government organizations during that time. As a result, due to a lack of coordination among these organizations, its implementation was lagging. Recently, the government and its partners have given attention to DTCs. More than 5847 professionals underwent DTC training from 2016 onwards. DTC establishment in health facilities improved from 85% to 98% between 2015 and 2019 during baseline and end-line assessments carried out by CHAI/CSP. Similarly, DTC functionality in HFs improved from 20% to 63%. The CHAI/CSP regular supervision data analysis revealed that DTC establishment improved from 83% to 100% of HFs, while its functionality improved from 5% to 72% between 2016 and 2019, respectively. A chi-square test of independence examining the relationship between facility and pharmacy head training on DTCs and functionality of DTC in the same facility revealed a significant association between the two variables at p<0.0001. Conclusions: Providing consistent capacity building and availing strong monitoring and evaluation system improves functionality of DTCs. Moreover, national coordinating bodies for DTCs and similar structures at Regional Health Bureaus and woreda health offices should be established.
Managing the Personalized Order-Holding Problem in Online Retailing
Authors: Chen Shouchang , Yan Zhenzhen , Lim Yun Fong 
Published: March 2023

Problem definition: A significant percentage of online consumers place consecutive orders within a short duration. To reduce the total order arrangement cost, an online retailer may consolidate consecutive orders from the same consumer. We investigate how long the retailer should hold the consumer’s orders before sending them to a third-party logistics provider (3PL) for processing. In this order-holding problem, we optimize the holding time to balance the total order arrangement cost and the potential delay in delivery. Methodology/results: We model the order-holding problem as a Markov decision process. We show that the optimal order-holding decisions follow a threshold-type policy that is straightforward to implement: Hold any pending orders if the holding time is within a threshold or send them to the 3PL otherwise. Whenever the consumer places a new order, the holding time is reset, and the threshold is updated based on a cumulative set of the past consecutive orders in the consumer’s shopping journey. Using a consumer’s sequential decision model, we personalize the threshold by finding its closed-form expression in the consumer’s order features. We determine the model’s coefficients and evaluate the threshold-type policy using the data of the 2020 MSOM Data Driven Research Challenge. Extensive numerical experiments suggest that the personalized threshold-type policy outperforms two commonly used benchmarks by having fewer order arrangements or shorter holding times. Furthermore, personalizing the order-holding decisions is significantly more valuable for “enterprise” customers. Managerial implications: Our research suggests a higher threshold for consumers who are more likely to place consecutive orders within a short duration. The consumers’ demographic information has a significant effect on the threshold. Specifically, the threshold is higher for “plus” consumers, female consumers, and consumers in the age group of 16–25 years. The threshold for tier 1 cities is lower than that for tier 2 to tier 4 cities but higher than that for tier 5 cities.History: This paper has been accepted as part of the 2020 MSOM Data Driven Challenge.Funding: This work was supported by the National Natural Science Foundation of China [Grants 71931009, 72201237, and 72231009], the Research Grants Council of Hong Kong [Grants 15501920 and 15501221], the Singapore Ministry of Education Academic Research Fund [Tier 1, Grant RG17/21; Tier 2, Grant MOE2019-T2-1-045], the Association of South-East Asian Nations Business Research Initiative Grant [Grant G17C20421], and the Neptune Orient Lines [Fellowship NOL21RP04].Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2023.1201 .
Frontiers in Service Science: Data-Driven Revenue Management: The Interplay of Data, Model, and Decisions
Authors: Chen Ningyuan , Hu Ming 
Published: March 2023

Revenue management (RM) is the application of analytical methodologies and tools that predict consumer behavior and optimize product availability and prices to maximize a firm’s revenue or profit. In the last decade, data has been playing an increasingly crucial role in business decision making. As firms rely more on collected or acquired data to make business decisions, it brings opportunities and challenges to the RM research community. In this review paper, we systematically categorize the related literature by how a study is “driven” by data and focus on studies that explore the interplay between two or three of the elements: data, model, and decisions, in which the data element must be present. Specifically, we cover five data-driven RM research areas, including inference (data to model), predict then optimize (data to model to decisions), online learning (data to model to decisions to new data in a loop), end-to-end decision making (data directly to decisions), and experimental design (decisions to data to model). Finally, we point out future research directions.Funding: The research of N. Chen is partly supported by Natural Sciences and Engineering Research Council of Canada Discovery [Grant RGPIN-2020-04038]. The research of M. Hu is in part supported by Natural Sciences and Engineering Research Council of Canada [Grant RGPIN-2021-04295].
Mueller matrix imaging polarimeter at the wavelength of 265  nm
Authors: Li Yuanhe , Li Yanqiu , Liu Ke , Zhou Guodong , Liu Lihui , Liu Aijun , Ma Ziyu 
Published: March 2023

Mueller matrix imaging polarimeters (MMIPs) have been developed in the wavelength region of >400nm with great potential in many fields yet leaving a void of instrumentation and application in the ultraviolet (UV) region. For the first time to our knowledge, an UV-MMIP is developed for high resolution, sensitivity, and accuracy at the wavelength of 265 nm. A modified polarization state analyzer is designed and applied to suppress stray light for nice polarization images, and the errors of the measured Mueller matrices are calibrated to lower than 0.007 in pixel level. The finer performance of the UV-MMIP is demonstrated by the measurements of unstained cervical intraepithelial neoplasia (CIN) specimens. The contrasts of depolarization images obtained by the UV-MMIP are dramatically improved over those obtained by our previous VIS-MMIP at the wavelength of 650 nm. A distinct evolution of depolarization in normal cervical epithelium tissue, CIN-I, CIN-II, and CIN-III specimens can be observed by the UV-MMIP with mean depolarization promotion by up to 20 times. This evolution could provide important evidence for CIN staging but can hardly be distinguished by the VIS-MMIP. The results prove that the UV-MMIP could be an effective tool in polarimetric applications with higher sensitivity.
The clinical and biomarker approach to predict sepsis mortality in pediatric patients
Authors: Yuniar Irene , Karyanti Mulya Rahma , Kurniati Nia , Handayani Desti 
Published: March 2023

Background Sepsis is a leading cause of pediatric morbidity and mortality. The prevalence of sepsis mortality in Indonesia varies between 22.5 to 52%.
Objective To identify the clinical criteria for predicting sepsis mortality and evaluate the performance of the PELOD-2 score.
Methods This retrospective cohort study included pediatric patients admitted to the emergency department or pediatric intensive care unit (PICU) of Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from January 2015 to May 2020. Demographic characteristics (age and sex), clinical manifestations [nutritional status, presence of shock, need for intubation, source of infection, inotrope use, mean arterial pressure, pulse rate, respiratory rate, and Glasgow Coma Scale (GCS) score], laboratory [leukocyte, platelet, neutrophil, and lymphocyte counts, neutrophil-to-lymphocyte count ratio (NLCR), procalcitonin, C-reactive protein (CRP), and lactate profile], PELOD-2 score, and mortality data were recorded as outcomes.
Results We analyzed data from 241 sepsis subjects. The overall mortality rate was 65%. Shock [OR 3.2 (95%CI 1.80 to -5.55, P<0.001)], GCS <9 [OR 2.4 (95%CI 1.30 to 4.23, P=0.005)], inotrope use [OR 3.1 (95%CI 1.74 to 5.5, P<0.001)], CRP >33.5 mg/L [OR 2.5 (95%CI 1.14 to 5.35, P=0.02)], and lactate level >2.85 [OR 2.1 (95%CI 1.02 to 4.56, P=0.04)] were considered significant predictors of mortality. A PELOD-2 cut-off score of >8 had optimal sensitivity (81.2%) and specificity (72.9%) to predict mortality, with an OR of 11.6 (95%CI 5.72 to 23.5, P<0.001).
Conclusion Shock, GCS score, inotrope use, CRP, and lactate level can serve as clinical biomarkers to predict mortality in pediatric sepsis. A PELOD-2 score of >8 can predict mortality with reasonably good sensitivity and specificity.
Enhancements in formal process description by using a formal method
Authors: Xin Cheng , Grunau Lukas , Thron Mario , Riedl Matthias 
Published: March 2023

AbstractTo facilitate the planning of product processes, the Formalized Process Description (FPD) model was proposed. It enables users to graphically describe the requirements of a production process. However, the FPD model has limits. To overcome these limits, this paper describes an extension of the FPD model, which is called the Extended FPD model. The objects in the Extended FPD model are assigned types and logical statements to represent their specifications. Hence, the expressive power of the FPD model is enhanced. In this paper, a formal definition of the Extended FPD model is also presented. Based on this definition, a set of rules is defined to detect the contradictions automatically in the Extended FPD model. In addition, the description of requirements by using the Extended FPD model can also enable the integration of more formal verification methods.
VR training and imagery training in esports
Authors: Ross-Stewart Lindsay , Lee Russell 
Published: March 2023

Abstract
This article focused on the recent interest in VR in sport and how this technology can and can not help Esport athletes. Summarizing that VR is likely not a tool needed in esports, the authors highlight ways that Esport athletes can incorporate imagery into their first-person perspective gaming film review in a way that increased their psychological skills and performance.
Ferritin-based nanomedicine for disease treatment
Authors: Zhu Yuanjun , Zhu Yuefeng , Cao Tianmiao , Liu Xiaoyu , Liu Xiaoyan , Yan Yi , Shi Yujie , Wang Jian-Cheng 
Published: March 2023

Abstract
Ferritin is an endogenous protein which is self-assembled by 24 subunits into a highly uniform nanocage structure. Due to the drug-encapsulating ability in the hollow inner cavity and abundant modification sites on the outer surface, ferritin nanocage has been demonstrated great potential to become a multi-functional nanomedicine platform. Its good biocompatibility, low toxicity and immunogenicity, intrinsic tumor-targeting ability, high stability, low cost and massive production, together make ferritin nanocage stand out from other nanocarriers. In this review, we summarized ferritin-based nanomedicine in field of disease diagnosis, treatment and prevention. The different types of drugs to be loaded in ferritin, as well as drug-loading methods were classified. The strategies for site-specific and non-specific functional modification of ferritin were investigated, then the application of ferritin for disease imaging, drug delivery and vaccine development were discussed. Finally, the challenges restricting the clinical translation of ferritin-based nanomedicines were analyzed.