bluuebunny/crossref_metadata_2025_split huggingface dataset:
NEO-SAFE: a clinical model for patients and healthcare personnel safety in primary level hospitals
Authors: Cetica Federica , Ciantelli Massimiliano , Carcione Simona , Scaramuzzo Rosa T , Bottone Ugo , Pellegrini Alessandra , Caiazzo Debora , Gagliardi Luigi , Luzi Cinzia , Lenzini Andrea , Bardelli Serena , Filippi Luca , Bellandi Tommaso , Cuttano Armando 
Published: July 2023

Abstract
Patient safety is a major concern in medicine. Approximately, 4 million infants die each year worldwide and 23% of these deaths are caused by perinatal asphyxia. To prevent the long-term damage of asphyxia, the resuscitation flowchart must be perfectly and promptly performed. However, high effectiveness in performing resuscitation can only be achieved and maintained if the algorithm is frequently executed. Therefore, maintaining a high level of patient care is difficult in some remote centres. The aim of this study was to evaluate the effectiveness of a new organizational model of care-network between Hub & Spoke hospitals to improve both the safety of the newborns in hospitals with a low number of births and the well-being of operators. Our project, NEO-SAFE (NEOnatal SAFety and training Elba), began in 2017 and involved the neonatal intensive care unit and the NINA Center of the Pisa University Hospital (hub) and the Hospital of Elba Island (spoke). It consisted of a continuous training program, both with ‘classic’ training course and ‘on-job tutoring’ (on side and remotely), of the health workers at spoke (i.e. nurses, midwives, and paediatricians). All four milestones of the study design were achieved. During the project, NINA Center instructors organized training courses for the staff in Portoferraio. These courses were based on learning technical and non-technical skills in a training course of increasing difficulty. Staff training needs were also monitored during the project by means of periodic questionnaires, sentinel events, and specific requests. The curve described by the rate of newborns transfer to the Pisa neonatal intensive care unit (hub) shows a monotonous decreasing trend line. On the other hand, this project allowed operators to develop greater self-confidence and greater safety in managing emergency situations, reducing stress for them and improving patient safety. The project allowed the creation of a safe, effective, low-cost, and reproducible organizational model for centres with a low number of births. Moreover, the tele-medicine approach is an important improvement in the assistance and is a window on the future.
Nondestructive, reagent-free, low-volume fluidic set-up to study biofilms by using a transparent electrode, allowing simultaneous electrochemical and optical measurements
Authors: Saavedra Albert , Martínez-Casillas Diana C , Collet-Lacoste Jean R , Cortón Eduardo 
Published: July 2023

Abstract

Aims
The aim was to develop an electrochemical/optical set-up and correlate it (as validation) with other chemical and physical methods to obtain a simple and cost-effective system to study biofilm formation.

Methods and Results
A simple microfluidic cell and methods allowed continuous monitoring of the first, critical steps of microbial attachment. We monitored sulfate-reducing bacteria (SRB) at the early stages of biofilm formation. Herein, we studied the formation and adherence of SRB consortium biofilms over an indium tin oxide (ITO) conducting surface using microbiological and chemical methods, microscopic observations [scanning electron microscopy (SEM) and optical], and electrochemical impedance spectroscopy (EIS) measurements. The SRB biofilm formation was evaluated for 30 d by SEM and EIS. Charge transfer resistance decreased when the microbial population colonized the electrode. The monitoring of early-stage biofilm formation was performed using EIS at a single frequency of 1 Hz during the first 36 h.

Conclusions
The simultaneous use of optical, analytical, and microbiological methods allowed us to connect the kinetics of the growth of the microbial consortium to the values obtained via the electrochemical technique. The simple setup we present here can help laboratories with limited resources to study biofilm attachment and facilitates the development of various strategies to control biofilm development in order to avoid damage to metallic structures (microbiologically influenced corrosion, MIC) or the colonization of other industrial structures and medical devices.
Impact of notification policy on patient-before-clinician review of immediately released test results
Authors: Steitz Bryan D , Padi-Adjirackor Nana Addo , Griffith Kevin N , Reese Thomas J , Rosenbloom S Trent , Ancker Jessica S 
Published: July 2023

Abstract
The 21st Century Cures Act mandates immediate availability of test results upon request. The Cures Act does not require that patients be informed of results, but many organizations send notifications when results become available. Our medical center implemented 2 sequential policies: immediate notifications for all results, and notifications only to patients who opt in. We used over 2 years of data from Vanderbilt University Medical Center to measure the effect of these policies on rates of patient-before-clinician result review and patient-initiated messaging using interrupted time series analysis. When releasing test results with immediate notification, the proportion of patient-before-clinician review increased 4-fold and the proportion of patients who sent messages rose 3%. After transition to opt-in notifications, patient-before-clinician review decreased 2.4% and patient-initiated messaging decreased 0.4%. Replacing automated notifications with an opt-in policy provides patients flexibility to indicate their preferences but may not substantially alleviate clinicians’ messaging workload.
A certified de-identification system for all clinical text documents for information extraction at scale
Authors: Radhakrishnan Lakshmi , Schenk Gundolf , Muenzen Kathleen , Oskotsky Boris , Ashouri Choshali Habibeh , Plunkett Thomas , Israni Sharat , Butte Atul J 
Published: July 2023

Abstract

Objectives
Clinical notes are a veritable treasure trove of information on a patient’s disease progression, medical history, and treatment plans, yet are locked in secured databases accessible for research only after extensive ethics review. Removing personally identifying and protected health information (PII/PHI) from the records can reduce the need for additional Institutional Review Boards (IRB) reviews. In this project, our goals were to: (1) develop a robust and scalable clinical text de-identification pipeline that is compliant with the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule for de-identification standards and (2) share routinely updated de-identified clinical notes with researchers.

Materials and Methods
Building on our open-source de-identification software called Philter, we added features to: (1) make the algorithm and the de-identified data HIPAA compliant, which also implies type 2 error-free redaction, as certified via external audit; (2) reduce over-redaction errors; and (3) normalize and shift date PHI. We also established a streamlined de-identification pipeline using MongoDB to automatically extract clinical notes and provide truly de-identified notes to researchers with periodic monthly refreshes at our institution.

Results
To the best of our knowledge, the Philter V1.0 pipeline is currently the first and only certified, de-identified redaction pipeline that makes clinical notes available to researchers for nonhuman subjects’ research, without further IRB approval needed. To date, we have made over 130 million certified de-identified clinical notes available to over 600 UCSF researchers. These notes were collected over the past 40 years, and represent data from 2757016 UCSF patients.
Forages and pastures symposium: an update on in vitro and in situ experimental techniques for approximation of ruminal fiber degradation
Authors: Foster Jamie L , Smith William B , Rouquette F Monte , Tedeschi Luis O 
Published: July 2023

AbstractStatic quantification measures of chemical components are commonly used to make certain assumptions about forage or feed nutritive value and quality. In order for modern nutrient requirement models to estimate intake and digestibility more accurately, kinetic measures of ruminal fiber degradation are necessary. Compared to in vivo experiments, in vitro (IV) and in situ (IS) experimental techniques are relatively simple and inexpensive methods to determine the extent and rate of ruminal fiber degradation. This paper summarizes limitations of these techniques and statistical analyses of the resulting data, highlights key updates to these techniques in the last 30 yr, and presents opportunities for further improvements to these techniques regarding ruminal fiber degradation. The principle biological component of these techniques, ruminal fluid, is still highly variable because it is influenced by ruminally fistulated animal diet type and timing of feeding, and in the case of the IV technique by collection and transport procedures. Commercialization has contributed to the standardization, mechanization, and automation of the IV true digestibility technique, for example, the well-known DaisyII Incubator. There has been limited commercialization of supplies for the IS technique and several review papers focused on standardization in the last 30 yr; however, the IS experimental technique is not standardized and there remains variation within and among laboratories. Regardless of improved precision resulting from enhancements of these techniques, the accuracy and precision of determining the indigestible fraction are fundamental to modeling digestion kinetics and the use of these estimates in more complex dynamic nutritional modeling. Opportunities for focused research and development are additional commercialization and standardization, methods to improve the precision and accuracy of indigestible fiber fraction, data science applications, and statistical analyses of results, especially for IS data. In situ data is typically fitted to one of a few first-order kinetic models, and parameters are estimated without determining if the selected model has the best fit. Animal experimentation will be fundamental to the future of ruminant nutrition and IV and IS techniques will remain vital to bring together nutritive value with forage quality. It is feasible and important to focus efforts on improving the precision and accuracy of IV and IS results.
Follow the Boots: A Case Study of Design and Global Value Chains
Authors: Hodson Elise 
Published: July 2023

Abstract
As manufacturing has become globally fragmented, so too has the work of design. Complex supply chains conceal sources of creativity and innovation, posing new challenges for researching design history. There is little understanding of how the globalization of manufacturing in the late-twentieth and early-twenty-first centuries has affected design practice or how design authorship might be identified in mass-produced objects. This case study follows a pair of steel-toed boots named Vanessa from concept through design, development, and production, moving from Canada to Italy, Mexico, and beyond. It maps components, equipment, and expertise, making it possible to trace sources and relationships of design. Analysis reveals how the boots reflect shifts in global trade and the concentration of knowledge and resources in new locations. It also shows how the globalization of production has influenced the role of the product designer who acts as intermediary within transnational networks, combining predesigned components and practices from around the world. The manufacturer, Mellow Walk, has experienced the transition from a regional manufacturing economy to one that is globally integrated. The company was founded in the 1990s when most Canadian footwear factories had closed due to global competition. It is unique as the last fully integrated footwear factory in Ontario, meaning that management, design, production, sales, and shipping happen under one roof. Mellow Walk nevertheless depends on international suppliers and, in this sense, represents many other footwear brands around the world.
Acaricide exposure impairs predatory behavior of the phytoseiid miteNeoseiulus idaeus(Acari: Phytoseiidae)
Authors: de Sousa Neto Eduardo P , Mendes Jairo de Almeida , Filgueiras Rosenya Michely Cintra , de Lima Debora B , Guedes Raul Narciso C , Melo José W S 
Published: July 2023

AbstractPredation is an important interaction that can change the structure of arthropod communities across both temporal and spatial scales. In agricultural systems predation can reduce the population levels of several arthropod pest species of a community. This predator–prey interaction involves the predator searching and handling behaviors. Several factors can affect this interaction, such as pesticide exposure, which is a frequent feature in agroecosystems. Thus, the hypothesis of our study is that the predatory behavior of the phytoseiid mite Neoseiulus idaeus Denmark & Muma, an important natural enemy of spider mites, is affected by acaricide exposure. To test that hypothesis, the predatory mite was exposed to the acaricides abamectin, fenpyroximate, and azadirachtin in 4 exposure scenarios. The predatory behavior of N. idaeus was negatively affected by acaricide exposure when the leaf surface containing both prey and predator was sprayed leading to a reduction in the frequency of transitions between predator walking and meeting preys. Prey handling and consumption were also compromised by acaricide exposure through contaminated leaf surface and prey, and contaminated leaf surface, prey, and predator. Abamectin compromised predation regardless of the exposure scenario. Acaricide-exposure reduced the number of prey found, number of attacks, and number prey killed by N. idaeus. Moreover, partial prey consumption was observed with acaricide-exposed mites. Thus, caution is necessary while attempting to integrate acaricide applications and mass release of N. idaeus for spider mite management.
Vintage factor analysis with Varimax performs statistical inference
Authors: Rohe Karl , Zeng Muzhe 
Published: July 2023

Abstract
In the 1930s, Psychologists began developing Multiple-Factor Analysis to decompose multivariate data into a small number of interpretable factors without any a priori knowledge about those factors. In this form of factor analysis, the Varimax factor rotation redraws the axes through the multi-dimensional factors to make them sparse and thus make them more interpretable. Charles Spearman and many others objected to factor rotations because the factors seem to be rotationally invariant. Despite the controversy, factor rotations have remained widely popular among people analyzing data. Reversing nearly a century of statistical thinking on the topic, we show that the rotation makes the factors easier to interpret because the Varimax performs statistical inference; in particular, principal components analysis (PCA) with a Varimax rotation provides a unified spectral estimation strategy for a broad class of semi-parametric factor models, including the Stochastic Blockmodel and a natural variation of Latent Dirichlet Allocation. In addition, we show that Thurstone’s widely employed sparsity diagnostics implicitly assess a key leptokurtic condition that makes the axes statistically identifiable in these models. PCA with Varimax is fast, stable, and practical. Combined with Thurstone’s straightforward diagnostics, this vintage approach is suitable for a wide array of modern applications.
Inference on extended-spectrum beta-lactamase Escherichia coli and Klebsiella pneumoniae data through SMC2
Authors: Rimella L , Alderton S , Sammarro M , Rowlingson B , Cocker D , Feasey N , Fearnhead P , Jewell C 
Published: July 2023

Abstract
We propose a novel stochastic model for the spread of antimicrobial-resistant bacteria in a population, together with an efficient algorithm for fitting such a model to sample data. We introduce an individual-based model for the epidemic, with the state of the model determining which individuals are colonised by the bacteria. The transmission rate of the epidemic takes into account both individuals’ locations, individuals’ covariates, seasonality, and environmental effects. The state of our model is only partially observed, with data consisting of test results from individuals from a sample of households. Fitting our model to data is challenging due to the large state space of our model. We develop an efficient SMC2 algorithm to estimate parameters and compare models for the transmission rate. We implement this algorithm in a computationally efficient manner by using the scale invariance properties of the underlying epidemic model. Our motivating application focuses on the dynamics of community-acquired extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae, using data collected as part of the Drivers of Resistance in Uganda and Malawi project. We infer the parameters of the model and learn key epidemic quantities such as the effective reproduction number, spatial distribution of prevalence, household cluster dynamics, and seasonality.
Severe pulmonary valve insufficiency caused by transjugular cannulation of pulmonary artery for right ventricular assist device: diagnosis and surgical solution—a case report
Authors: Wert Leonhard , Lanmüller Pia , Ott Sascha , Mulzer Johanna , Starck Christoph T , Falk Volkmar , Potapov Evgenij V 
Published: July 2023

Abstract
Implantation of a temporary percutaneous right ventricular assist device (RVAD) in patients with right heart failure after left ventricular assist device (LVAD) implantation is an established technique that may cause complications. We present a 60-year-old male patient who underwent urgent LVAD implantation. On the second postoperative day the patient developed acute right heart failure. We implanted a temporary percutaneous RVAD with two cannulas via the right internal jugular vein and the right femoral vein. Transesophageal echocardiography revealed severe pulmonary insufficiency. After performing re-sternotomy we anastomosed a prosthetic graft to the pulmonary trunk (PT), performed subxiphoid tunneling of the graft and replaced the transjugular outflow cannula. The pulmonary regurgitation caused by the percutaneous transvalvular cannula disappeared. In such case a direct anastomosis to the PT is the solution.
Unveiling the mystery of sigmoid volvulus with multiple adhesions—an unusual case report
Authors: Jatoth Surendar , Suvvari Tarun K , J Shashank , Afsar Aiman P , Ravipati Shivani , Mukkamala Lakshmi S , Thomas Vimal 
Published: July 2023

Abstract
Intestinal obstruction is a common surgical emergency that requires prompt intervention. We present a case report of a 30-year-old male with recurrent intestinal obstruction due to sigmoid volvulus. Our case highlights the challenges associated with managing recurrent intestinal obstructions caused by adhesions following surgical interventions for sigmoid volvulus. It emphasizes the need for careful evaluation and meticulous surgical techniques to minimize the risk of adhesion formation and subsequent complications.
There’s Something Bad in the Packs: A Vernacular Aramaic Phrase in al-Ṭabarī’s and al-Masʿūdī’s Histories?
Authors: Leube Georg , Häberl Charles G 
Published: July 2023

Abstract
Although Aramaic was spoken throughout the Middle East before the Muslim Conquest and continues to be spoken by communities across the region and beyond, evidence for its spoken forms is scarce before the early modern period. One rare such witness is a stray Aramaic phrase, transcribed and translated into Arabic, which appears within the Taʾrīx of al-Ṭabarī (d. 923 ce) and the Murūj al-ḏahab of al-Masʿūdī (d. 956 ce). Its immediate context is a narrative concerning the conflict between Tadmur/Palmyra and al-Ḥīra contemporary with the rise of the Sasanians. Based upon its attested versions and the morpho-syntactic evidence of the phrase itself, we nonetheless conclude that it likely represents a vernacular form of ʿIrāqī Aramaic which must have been transparent within Arabic-Islamic scholarly milieus of the second and third century AH/eighth and ninth century ce, rather than an authentically transmitted Aramaic proverb from the third century ce.
Injuries and medical emergencies among international travellers
Authors: Potin Mathieu , Carron Pierre-Nicolas , Genton Blaise 
Published: July 2023

AbstractBackgroundTropical infectious diseases and vaccine-preventable emergencies are the mainstay of pre-travel consultations. However, non-communicable diseases, injuries and accidents that occur during travel are not emphasized enough in these settings.MethodsWe performed a narrative review based on a literature search of PubMed, Google Scholar, UpToDate, DynaMed and LiSSa and on reference textbooks and medical journals dedicated to travel, emergency and wilderness medicine. Relevant secondary references were extracted. We also aimed to discuss newer or neglected issues, such as medical tourism, Coronavirus Disease 2019, exacerbations of co-morbidities associated with international travel, insurance coverage, health care seeking abroad, medical evacuation or repatriation and tips for different types of travellers’ emergency medical kits (personal, group, physician handled).ResultsAll sources reviewed led to the selection of &gt;170 references. Among epidemiological data on morbidity and deaths while abroad, only retrospective data are available. Deaths are estimated to occur in 1 in 100 000 travellers, with 40% caused by trauma and 60% by diseases, and &lt;3% linked to infectious diseases. Trauma and other injuries acquired during travel, such as traffic accidents and drowning, can be reduced by up to 85% with simple preventive recommendations such as avoiding simultaneous alcohol intake. In-flight emergencies occur on 1 in 604 flights on average. Thrombosis risk is two to three times greater for travellers than for non-travellers. Fever during or after travel can occur in 2–4% of travellers, but in up to 25–30% in tertiary centres. Traveller’s diarrhoea, although rarely severe, is the most common disease associated with travel. Autochthonous emergencies (acute appendicitis, ectopic pregnancy, dental abscess) can also occur.ConclusionsPre-travel medicine encounters must include the topic of injuries and medical emergencies, such as the risk-taking behaviours and foster better planning in a comprehensive approach along with vaccines and infectious diseases advices.