bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous Determination of 16-Hydroxystrychnine and Demethylbrucine
by LC-MS/MS in Rat Urine and Its Application to Pharmacokinetic
Study
Authors: Yan Rui , Xia Bin , Zhang Shan 
Published: April 2023

Introduction:
This paper aimed to establish a method to help investigate the combination mechanism of traditional Chinese medicine from the metabolic perspective.

Background:
Semen Strychni has been a frequently used herb in clinics for a long time. In traditional
Chinese medical science, Semen Strychni always combinate with other herbs to modulate its nature
of severe toxicity. However, the mechanism of the combination is still unclear. Previous research
mostly focused on the components of the herbs. The metabolic processes of the main components
of the Semen Strychni are also very important and have rarely been reported.

Objective:
This study tended to develop a rapid and sensitive high-performance liquid chromatographic-tandem mass spectrometric (HPLC-MS/MS) method for the determination of two major
metabolites of Semen Strychni in rat urine.

Methods:
Chromatographic separation was carried out on a C18 column. Detection was performed
by a selective reaction monitoring (SRM) mode via an electrospray ionization (ESI) source operating
in the positive ionization mode. Analysis of analytes from rat plasma was carried out by protein
precipitation using acetonitrile.

Results:
The assay was validated in terms of specificity, precision, recovery, etc. The intra- and
inter-day precision values were less than 13.1%. The recoveries at three levels were more than
69.1%. The method was then used to study the kinetic profiles of the metabolites of Semen Strychni
in rat urine for the first time.

Conclusion:
The results demonstrate that the established LC/MS method in this study is accurate
and sensitive for the simultaneous determination of the two metabolites of Semen Strychni in rats'
urine samples. This method could be a supplement to the plasma pharmacokinetics of Semen
Strychni.
Optimization of Holding Force for a Climbing Robot Based on a Differential
Evolutionary Algorithm
Authors: Masike Rujeko , Kaur Karamjit , Arora Rajesh , Shridhara Somalapura Nagappa 
Published: April 2023

Background:
The advancements in robotic technology have completely revolutionized
day-to-day life. In industrial applications, the implementation of robotics is quite advantageous as
it may help in performing dangerous tasks like climbing high walls, working in a high-temperature
environment, high radiation exposure conditions etc.

Methods:
This paper presents the design and development of a wall-climbing robot for dam wall
inspection using an adaptive aerodynamic adhesion technique. The optimization of a robot design
is done using a differential evolutionary algorithm.

Results:
In the proposed model, the principle of Bernoulli adhesion is used for designing the suction
pad. The optimization of various variables is done using a differential evolutionary algorithm
to improve the efficiency and effectiveness of the wall climbing robot adhesion.

Conclusion:
The results of the proposed system show that the approach can find an optimal holding
force and can be effectively used for applications like dam wall climbing for inspection.
On Powder Bed Fusion Manufactured Parts: Porosity and its Measurement
Authors: Morano Chiara , Pagnotta Leonardo 
Published: April 2023

Abstract:
Powder Bed Fusion (PBF) is one of the earliest, most versatile, and popular AM processes,
being well-suited for a great variety of materials. As in many other manufacturing processes,
porosity is a phenomenon inevitably present in parts made by PBF. The quantity, shape,
and distribution of pores, and the propensity to their formation depend strongly upon the type of
process and on the processing conditions used to produce the part. It is well known that porosity
influences in a dramatic way the quality and reliability of the manufactured materials and, therefore,
it deserves special attention.

:
In this paper, porosity and the more appropriate experimental techniques for detecting and measuring
porosity are reviewed. Moreover, a comparison among the results obtained by applying different
methodologies to measure the porosity of parts produced by Powder Bed Fusion is reported.
The final purpose of the work is to provide the reader with the tools for the correct choice of
the most suitable method for measuring the porosity of additively manufactured pieces.
Yield and yield components of superior cocoa (Theobroma cocoa L.) clones rejuvenated by ring budding technique
Authors: Wahyudi Resti Utari , Susila Putra Eka Tarwaca , Indradewa Didik 
Published: April 2023

The ring budding technique gave a higher suitability for rejuvenation of cocoa plants compared to side cleft grafting it can be combined with the use of superior clones for optimal production. However, information related to this is still limited. The research aimed to determine the effects of ring budding technique on yield components and yields of three types of superior cocoa clones. The experiment was arranged in a Nested Design. The first factor is the type of vegetative propagation technique, consisting of side cleft grafting and ring budding. The second factor was clones, which consisted of clones KKM 22, RCC 70 and RCC 71. Clones were nested in vegetative propagation. The research was conducted from September 2020 to January 2021 at the Pagilaran Company. Observations were made on several yield component variables. The data were analyzed using Analysis of Variance (ANOVA) and continued with the Least Significant Difference Test (LSD) at the 5%. The results showed that the number of pods and the weight of beans per cocoa stand were significantly higher in the ring budding technique than the side cleft grafting. This condition caused the dry bean weight per hectare much higher as well. The three cacao clones, which were rejuvenated by ring budding, gave a good response and high yields. Meanwhile, only KKM 2 gave good response and high yield after treated with side cleft grafting technique, while RCC 70 and RCC 71 clones gave low yields. The KKM 22 clone is the best option in terms of rehabilitation with ring budding and side cleft grafting.
Tratamiento de apiñamiento severo sin extracciones con sistema de autoligado Damon®: reporte de caso
Authors: Carillo-Padilla Sahian Abigail , Benítez Vázquez Tania Jocelyn , Ávila Santacruz Salma Eugenia , Rodríguez-Chávez Jacqueline Adelina , Moreno Martínez Victor Omark , Orozco Varela Carlos 
Published: April 2023

Introducción: la planificación del tratamiento de una maloclusión clase II con apiñamiento severo estará determinada por el análisis clínico-estomatológico, analizando los efectos colaterales en un sistema de fuerzas y evaluando su repercusión en los tejidos blandos. Objetivos: mantener perfil facial, descruzar mordida de lado derecho, eliminar apiñamiento, establecer clase I canina y clase I molar. Diagnóstico y plan de tratamiento: paciente masculino, 13 años, dentición permanente. Clase II canina unilateral de lado derecho, apiñamiento severo, mordida cruzada posterior unilateral derecha. Colocación de aparatología de autoligado, bite turbo, elásticos iniciales clase II y botones palatinos para elásticos cruzados. Resultados: se corrigió la mordida cruzada y se consiguió la clase I canina manteniendo el perfil recto del paciente. Conclusión: el presente reporte muestra que la corrección de apiñamiento severo y una clase II unilateral puede realizarse sin extracciones, logrando un adecuado resultado funcional y estético. Además, es posible efectuar dicha corrección aprovechando las ventajas que nos proporciona el sistema de autoligado.
APLICAÇÃO DO ULTRASSOM MICROFOCADO NO REJUVENESCIMENTO FACIAL: UMA REVISÃO DA LITERATURA
Authors: Dos Santos Vianna Néri Júlia , Silva Souza Daniel Adrian , Borges de Lima Dantas Juliana , Aparecida Marques Lima Anuska , Mendonça da Silva Adriana 
Published: April 2023

Introdução: O aumento da expectativa média de vida leva a população a buscar, com maior frequência, tratamentos estéticos que visem o rejuvenescimento da face e do pescoço. O Ultrassom microfocado (MFU) é descrito como uma opção de tratamento não-invasiva para a flacidez facial e o envelhecimento. Objetivo: Revisar a literatura científica quanto ao uso do MFU no processo de rejuvenescimento facial e correção da flacidez da pele. Metodologia: Trata-se de uma revisão narrativa da literatura, baseada na pesquisa de artigos científicos nas bases de dados PubMed e Biblioteca Virtual em Saúde realizada durante o mês de março de 2022, através da seguinte estratégia de busca: “Microfocused Ultrasound AND Facial Rejuvenation AND Skin Laxity Treatment”. Um total de 19 manuscritos foram incluídos em síntese qualitativa. Desenvolvimento: O MFU pode ser aplicado no tecido subcutâneo, produzindo pequenos pontos de coagulação térmica dentro da camada reticular média a profunda da derme e subderme. A aplicação de calor nesses discretos pontos de coagulação térmica faz com que haja neossíntese de colágeno e consequente enrijecimento da pele. Estudos recentes evidenciaramresultados promissores quanto a aplicação do MFU em regiões de sulco nasolabial, linha da mandíbula, sobrancelhas, região infraorbital, palpebra inferior e ligamentos de retenção zigomático-bucais. Considerações finais: O MFU tem se mostrado uma técnica segura, sendo considerado eficaz, não-invasiva, bem tolerada pelos pacientes e viável para a prática clínica médica e odontológica.
Palavras-chave: Envelhecimento da Pele; Terapia por Ultrassom; Equipamentos para Estética; Odontologia.
Kinerja Dinas Sosial Dalam Melaksanakan Program Pembinaan Anak Jalanan di Kota Palembang
Authors: Yuliana Yuyun , Isabella Isabella , Febriyanti Doris 
Published: April 2023

Kinerja dinas sosial dalam pelaksanaan program pembinaan anak jalanan di kota Palembang cukup baik karena adanya penurunan jumlah anak jalanan.Isu ini, yang cukup penting dari perspektif kesejahteraan sosial, muncul dalam kasus penitipan anak jalanan, di mana di sebagian besar wilayah jumlah anak jalanan semakin meningkat. Masyarakat dalam lingkungan kemiskinan lah sebagai penyebab utama munculnya anak jalanan. Perkembangan jumlah anak jalanan yang belakangan ini makin mencemaskan, hingga menjadi masalah sosial yang membutuhkan pemecahan segera. Hal tersebut disebabkan oleh situasi krisis ekonomi dan urbanisasi berlebih (over urbanization) di kota besar. Fenomena ini mudah terlihat di persimpangan atau di lampu merah dan halte bus. Jumlah anak jalanan terus bertambah dan bertambah, meskipun ada upaya, baik oleh pemerintah maupun lembaga swadaya masyarakat (LSM), untuk mengurangi jumlah anak yang hidup di jalanan. Khususnya Kota Palembang. Penelitian ini menggunakan metode deskriptif kualitatif, menggunakan wawancara, dokumen dan diukur melalui teori kinerja petugas dinas sosial kota palembang periode 2020-2021, dengan hasil kinerja dinas sosial dalam menangani anak jalanan karena anak selalu turun jalan.
PENGEMBANGAN E-PLANNING BERBASIS WEBSITE PADA BADAN PERENCANAAN PEMBANGUNAN DAERAH KOTA PALEMBANG
Authors: Miranda Adelia , Kencana Novia , Kariem M. Qur'anul 
Published: April 2023

Perkembangan teknologi di era globalisasi menjadi semakin cepat dan berkembang setiap sektor dituntut untuk beradaptasi dengan perkembangan teknologi pada zaman sekarang. Salah satu kota di Indonesia yang telah menerapkan sistem perencanaan (e-Planning) guna menerapkan Good Governance dalam menjalankan urusan pemerintahannya adalah Kota Palembang. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengembangan e-planning berbasis website pada Badan Perencanaan Pembangunan Daerah Kota Palembang. Penelitian dilakukan di Badan Perencanaan Pembangunan Daerah Kota dengan menggunakan metode penelitian kualitatif. Hasil penelitian menunjukkan bahwa pengembangan e-planning di Badan Perencanaan Pembangunan Daerah Palembang telah mencapai tahapan transaksi, yang disebakan karena masyarakat masih belum memiliki akses untuk penggunaan website e-planning itu sendiri. Sehingga masyarakat tidak dapat melihat proses hingga hasil dari perencanaan pembangunan Kota Palembang melalui website e-planning tersebut. Lebih jauh transparansi dalam proses perencanaan pembangunan daerah masih dinilai semu karena partisipasi masyarakat yang belum optimal dalam penggunaan website e-planning itu sendiri. Pemerintah harus memberi masyarakat kewenangan untuk dapat mengakses website E-Planning agar dapat melihat proses hasil dari Perencanaan pembangunan Kota Palembang melalui website e-planning tersebut. Seharusnya badan perencanaan pembangunan daerah kota palembang lebih transparan dan akuntabel dalam mewujudkan E-government.
STRATEGI PEMERINTAH DAN MASYARAKAT DALAM MENJEMPUT DAERAH OTONOMI BARU PAPUA BARAT DAYA PEMEKARAN PROVINSI PAPUA BARAT
Authors: Sinen Karmila , Sasmitha Ningrum Aulia , Angela Kabes Oktoviana 
Published: April 2023

Pembentukan daerah otonom merupkan salah satu kebijakan dalam peningkatan pelayanan publik dengan memberikan hak pemerintah daerah dalam mengembangkan potensi masing-masing daerah. Daerah otonom dapat terbentuk apabila memenuhi faktor kemampuan ekonomi, potensi daerah, sosial budaya, kependudukan, luas daerah, pertahanan, keamanan, rentang kendali, dan faktor lainnya. Papua barat merupakan salah satu wilayah Indonesia yang terletak cukup jauh daeri pemerintahan pusat. Kesejahteraan masyarakat Papua Barat kurang baik akibat jauhnya komunikasi antara pemerintah pusat dan daerah. Oleh karena itu perlu diterapkannya strategi dalam menjemput daerah otonomi baru di Papua Barat guna pemakaran provinsi Papua Barat. Sehingga penelitian kualitatif ini dilakukan untuk menganalisis strategi pemekaran wilayah Papua Barat. Hasil dari penelitian ini diharapkan dapat menjadi pertimbangan strategi pemerintah dalam pembentukan daerah otonom di Papua Barat. Pemekaran daerah ini tidak cukup hanya sampai di tingkat provinsi, tapi harus diikuti sampai pemekaran di tingkat kabupaten, sehingga pemekaran wilayah sampai hingga di tingkat distrik atau kelurahan. “Komisi II DPR berharap, agar pemerintah daerah bisa tetap bersatu dan bersinergi dengan masyarakat menyambut pemekaran ini dengan tujuan orientasi percepatan pembangunan di Papua, khususnya lagi di Papua Barat, dan lebih khusus lagi di Papua Barat Daya. Lebih jauh, Pemerintah Provinsi Papua Barat dan masyarakat setempat mendukung pemekaran Papua Barat melalui RUU tentang Pembentukan Provinsi Papua Barat Daya. Terlebih, saat ini situasi politik dan keamanan di Papua Barat sudah lebih stabil dan terkendali
Estructura organizacional de RSU para la Universidad Juárez Autónoma de Tabasco
Authors: Banda Izeta Herminia , Juárez Solís Sandra , Rodríguez Ocaña Leticia , Rico Meza Jorge Humberto 
Published: April 2023

The organizational structure of RSU for the Universidad Juarez Autonoma de Tabasco, aims to design the organizational structure that addresses the commitment and social responsibility to the Sustainable Development Goals of the 2030 Agenda. To achieve this objective, the theoretical elements of the Organizational design.
Starting from the fact that the design of an adequate organizational structure contributes to improving competitiveness. In public or private, profit-making or non-profit organizations, it is necessary to define the different functional area that are developed to achieve the objetives established in the design of the internal organizational structure that formally establishes the levels of authority responsibility. The division into functional areas and the design of the structure should be flexible enough to a llow dynamic and project-based management.
In the samy way, the commitment acquired by the Universidad Juárez Autónoma de Tabasco is considered, when obtaining the RSU badge in 2016 and later in 2019 endorses said commitment.
El impacto de los influencers en la toma de decisión de compra de los consumidores
Authors: Aguilar Alejandro Gloria Guadalupe , Neme Everardo Ramon 
Published: April 2023

Over time consumer behavior has been changing according to their new habits and needs, and with it, new technologies have been evolving hand in hand, so it is due that companies are adapting to new trends.
The so-called influencers or content creators have generated great commotion among consumers and especially in the big brands that have implemented them, obtaining great sales results, but, how big is the impact that these influencers have come to have to be an important point in the consumer's purchase decision making? This is a question that perhaps many of us have asked ourselves, that is why the objective of this research is to know "the impact of influencers in the purchase decision making of consumers".
Therefore, in this research we will analyze influencer marketing for which a survey has been applied and analyzed the case of one of the most popular influencers in Mexico. On the other hand, a discussion was made regarding the results of these two applied researches, at the end we conclude with a verdict on what was previously analyzed and specifying if the expected objectives of this research were reached in addition to a fact about influencer marketing.
Impacto Covid-19 en los estudiantes de la Universidad Popular de la Chontalpa (IM-COVID-UPCH)
Authors: Aguirre Andrade Antonio , Sanchez Trinidad Rosa del Carmen , Sánchez Cruz Samantha , Castillo Méndez Rocío del Carmen , De Dios Domínguez Wilber , Márquez Amaro Raymundo , Sanchez Trinidad Adriana del Carmen 
Published: April 2023

The research presented in this article was developed in an institution of higher education located in the state of Tabasco with the purpose of learning how the pandemic caused by SARS-CoV2 (COVID-19) affected its students, given the urgent need to close educational spaces and activate a distance learning scheme, The concern also arose to have information on the socio-demographic characteristics of the students of the Universidad Popular de la Chontalpa, the availability for the use of technological tools, their environmental conditions, the inconveniences of this situation both in their own performance, that of their teachers and that of the institution.
This information could be very useful for UPCH, because it allows contextualizing the difficulties, advantages, disadvantages experienced and the areas of opportunity that arose due to a new and abrupt way of learning.
Theoretical and conceptual aspects of customs regulation of export
Authors: Neudakhin V. S. 
Published: April 2023

The development of export is one of the most important directions of the economic policy of the Russian Federation at the present stage. Customs regulation is one of the main instruments of economic policy aimed at the development of exports.The concept of the customs regulation of the export of goods, as an element of the system of state regulation of foreign trade is analyzed in the article. The features of customs regulation of export, which distinguish it from other areas of the state’s economic policy in relation to the development of export, are determined. Particular attention is paid to setting the goal of customs regulation of the export of goods as a benchmark for assessing the quality and development of tools of customs regulation of the export of goods in a specific industry. It is concluded that, regardless of the regulated industry, the goal of customs regulation of export is to ensure the domestic market (avoiding shortages) or restructuring export. This goal is achieved by influencing the volume of exports of goods by measures of customs–tariff and non–tariff regulation.
The impact of crisis manifestations on the trends of socio–economic indicators of the Vladimir region
Authors: Vlasenko K. A. 
Published: April 2023

: Over the past few years, the Russian Federation has been repeatedly exposed to external negative influences. The destabilizing effects of the pandemic and sanctions require special attention from the Government of the country. Various anti–crisis measures are being developed, including measures to support the most vulnerable socio–economic systems.The stability of the country’s economy to crisis manifestations depends on the level of economic development of individual subjects. Accordingly, it is necessary to systematically analyze their trends and monitor changes.This article presents the indicators of the Vladimir region. The dynamics of the population and average per capita income for the period 2010–2021 are graphically presented, as well as the forecast up to 2025. The article examines the change in the growth rates of the main socio[economic indicators for three periods: pre–crisis and crisis. To systematize the studied parameters, a factor analysis was carried out, which allowed them to be divided into 3 groups: fixed assets, the human factor and innovative activity. A high direct correlation was revealed between the latter and GRP.
Factors for improving the quality of life of the population of Russia
Authors: Ghukasyan N. T. 
Published: April 2023

The study examines theoretical and methodological approaches to the study of the concept of «level and quality of life of the population», the main legal acts regulating the activities of authorities in this area in the Russian Federation. Effective methods of improving the standard of living and quality of life of the population of any state, ensuring their sustainable growth in a complex dynamic and unstable environment are the core of the modern economy. Process management, aimed at improving the standard of living and quality of life of the country’s population, first of all, the need to solve problems of high complexity and importance, for example, the dilemma of economic growth and living standards, in connection with the adoption of important informed management decisions on this problem, because this is a key and a difficult question. The relevance of the research topic is determined by the fact that in order to achieve a high standard of living and improve the quality of life of the population of our country, it is necessary to: implement the main goals of socio[economic development at the municipal, federal and state levels; getting rid of the differentiation of the socio[economic growth of regions, leading to the stratification of society; improving the quality of labor, production efficiency, the level of quality of products. Improving the quality of life makes it possible to provide additional jobs, develop all spheres of human life, change its infrastructure, change the demographic situation, determine the need to create a decent standard of living for the population, reduce the ranking of society in terms of income as a system of legal and socio[economic guarantees that provide decent and socially acceptable the quality of life of society.