bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemotherapy response in low‐grade serous ovarian carcinoma at a comprehensive cancer center: Readdressing the roles of platinum and cytotoxic therapies
Authors: Manning‐Geist Beryl L. , Kahn Ryan M. , Nemirovsky David , Girshman Jeffrey , Laibangyang Anya , Gordhandas Sushmita , Iasonos Alexia , Chui M. Herman , Long Roche Kara , Zivanovic Oliver , Chi Dennis S. , Aghajanian Carol , Grisham Rachel N. 
Published: March 2023

AbstractBackgroundData on platinum sensitivity of low‐grade serous ovarian carcinoma (LGSOC) in the upfront setting is lacking, and there is limited and contradictory information on chemotherapy responses in recurrent disease.MethodsPatients with LGSOC seen at a comprehensive cancer center from January 1, 1998 to September 30, 2021 were identified from institutional databases. Response to neoadjuvant chemotherapy (NACT) or adjuvant platinum‐based chemotherapy and to second‐ to fifth‐line regimens was retrospectively characterized by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Wilcoxon rank‐sum and two‐tailed Fisher exact tests were employed.ResultsOf 50 patients, 12 received platinum doublets for suboptimal residual disease and 11 as NACT. Of 12 patients with suboptimal residual disease, seven (58%) achieved objective responses (five partial responses [PRs] and two complete responses); of the 11 patients who underwent NACT, one (9%) achieved a PR (p = .027). The 15 remaining patients had stable disease on first‐line platinum chemotherapy. Of 44 patients who recurred, 20 had RECIST‐evaluable responses to second‐line and 27 to third‐line chemotherapy. Objective response rates to platinum‐based chemotherapy were 22% (two of nine) in the second line and 10% (one of 10) in the third. In second and third lines, highest response rates were observed with nonplatinum chemotherapy with bevacizumab, at 100% (two of two) and 30% (three of 10), respectively.ConclusionsPrimary platinum‐based chemotherapy has moderate activity in LGSOC and minimal activity in the recurrent setting, suggesting standard definitions of platinum sensitivity may not apply in LGSOC. In the second and third lines, nonplatinum chemotherapy/bevacizumab elicited the highest response rates.
Poor pretransplantation minimal residual disease clearance as an independent prognostic risk factor for survival in myelodysplastic syndrome with excess blasts: A multicenter, retrospective cohort study
Authors: Ma Ying‐Ying , Wei Ze‐liang , Xu Ya‐Jing , Shi Ji‐Min , Yi Hai , Lai Yong‐Rong , Jiang Er‐Lie , Wang San‐Bin , Wu Tao , Gao Lei , Gao Li , Kong Pei‐Yan , Wen Qin , Bai Hai , Li Yu , Cao Yi‐geng , Li Qiao‐Chuan , Zhang Zhong‐Ming , Liu Bei‐Cai , Su Yi , Lai Xiao‐Yu , Ma Xia , Cheng Ting‐Ting , Luo Yi , Zhang Xi , Zhang Cheng 
Published: March 2023

AbstractBackgroundMinimal residual disease (MRD) is an important prognostic factor for survival in adults with acute leukemia. The role of pretransplantation MRD status in myelodysplastic syndrome with excess blasts (MDS‐EB) is unknown. This study retrospectively analyzed the relationship between pretransplantation MRD status and long‐term survival.Materials and MethodsPatients with MDS‐EB who underwent allogeneic hematopoietic stem cell transplantation (allo‐HSCT) from March 5, 2005, to November 8, 2020, were included. The relationship between pretransplantation MRD status and long‐term survival was analyzed using univariate and multivariate logistic regression models.ResultsOf 220 patients with MDS‐EB who underwent allo‐HSCT, 198 were eligible for inclusion in this multicenter, retrospective cohort study. Complete remission was attained in 121 (61.1%) patients, and 103 patients underwent detection of MRD pretransplantation, with 67 patients being MRD‐positive and 36 patients being MRD‐negative. The median follow‐up time was 16 months, the median age was 41 years (6–65 years), and 58% of the patients were men. The 3‐year disease‐free survival (DFS) and overall survival (OS) probabilities for all patients were 70.1% and 72.9%, respectively. For patients in complete remission, the 3‐year DFS and OS probabilities were 72.2% and 74.8%, respectively. Further analysis found that the 3‐year DFS rates of MRD‐negative and MRD‐positive patients were 85.6% and 66.5% (p = .045), respectively, whereas the 3‐year OS rates were 91.3% and 66.4% (p = .035), respectively. Univariate and multivariate analyses showed that poor pretransplantation MRD clearance was an independent prognostic risk factor for DFS and OS.ConclusionPoor pretransplantation MRD clearance is an independent prognostic risk factor for long‐term survival after allo‐HSCT for patients with MDS‐EB.Plain language summary

Poor minimal residual disease clearance pretransplanation is an independent prognostic risk factor for long‐term survival after allogeneic hematopoietic stem cell transplantation for patients with myelodysplastic syndrome with excess blasts.
Age‐related changes in surface reflection, diffuse reflection, and subsurface scattering light of facial skin: Luminance value measured by the system for the optical properties of facial skin
Authors: Kikuchi Kumiko , Katsuyama Masako , Shibata Takako , Hardeberg Jon Yngve 
Published: March 2023

AbstractWe have developed a system that separates and measures the optical properties of skin that determine its visual quality, that is, the surface reflection, diffuse reflection, and subsurface scattering components of the skin. This system includes two polarization filters that separate light from the skin into a surface reflection component image and a diffuse reflection component image. Furthermore, by using a projector as a light source and irradiating the skin using a high‐frequency binary illumination pattern, the subsurface scattering component image alone can be separated and generated. Application of an algorithm that calculates the luminance value Y for each component image not only makes it possible to analyze each light signal from the skin quantitatively, but also enables understanding of how each light signal is related to the skin's overall appearance. Using the proposed system, we performed a survey of 154 Japanese women aged from their 20s to their 70s and analyzed age‐related changes in the optical properties of their skin. The results revealed the following. First, the luminance value Y of the surface reflection from the cheek and its standard deviation within the analysis area increase with age. Second, the Y value of diffuse reflection from the skin decreases with age. Third, the amount of light in the subsurface scattering components also decreases with age. The proposed system is expected to be suitable for a wide range of applications, including color science, and various studies of the appearance of human skin.
Animal Models for the Study of Food Allergies
Authors: Kazemi Sahar , Danisman Ece , Epstein Michelle M. 
Published: March 2023

AbstractIn the last decades there has been a parallel increase in the incidence of food allergies and the development of experimental mouse models. These models have improved our understanding of the disease but do have limitations. For instance, they do not entirely reproduce human pathophysiology; moreover, validated and predictive models are absent. Nevertheless, the models provide opportunities to further understand fundamental disease mechanisms. The selection of any of the many experimental models depends on the research aims. This overview focuses on IgE‐mediated food allergy in wild‐type, genetically modified, and humanized mouse models and presents a comprehensive overview of the currently used protocols, challenges, and limitations, as well as provides guidelines for model selection based on the three critical areas of research: 1) safety assessment, 2) evaluating treatment, and 3) elucidating pathophysiology. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.
Leaf phyllosphere microbiome and crop productivity under climate warming
Authors: Wang Jianqing 
Published: March 2023

AbstractClimate warming is an incontrovertible fact, seriously threatening microbial reproduction and food security. Crop‐associated leaf phyllosphere microbiome plays a crucial role in regulating crop productivity, plant health, stress resistance, pathogen resistance, and even mitigating climate warming. However, empirical evidence for the impact of climate warming on leaf phyllosphere‐associated microbiomes and crop productivity is lacking. I am writing to urge research into the linkage between leaf phyllosphere microbiome and crop productivity under climate warming to develop effective food productivity strategies in the future.
High voltage‐gain and wide‐range input DC‐DC converter using single switch suitable for fuel‐cell hybrid vehicles
Authors: Esmaili Siamak , Feyzi Mohammadreza , Bannae Sharifian Mohammad Bagher , Sabahi Mehran 
Published: March 2023

SummaryIn this paper, a new high voltage‐gain DC‐DC converter with wide‐range input is presented suitable for hybrid electric vehicle applications. The proposed structure acts as an interface converter between the fuel cell and DC link. The main benefits of the proposed topology consist of low voltage stress across semiconductors, flexibility of duty cycle changes without voltage fluctuations at the output side, having only one switch, and simple controls. Using a power switch with lower resistance on state (Rds‐on) reduces the total losses of the proposed topology. The proposed converter is analyzed in both CCM and DCM operating modes. Finally, a laboratory prototype at operating 50 kHz with 135 W is built and tested.
Greater dietary variety is associated with lower food anxiety at discharge from intensive eating disorder treatment
Authors: Vanzhula Irina , Duck Sarah Ann , Pletch Allisyn , Guarda Angela S. , Schreyer Colleen 
Published: March 2023

AbstractObjectiveFood anxiety and limited dietary variety often persist after intensive treatment for eating disorders (EDs) and may contribute to relapse. Prior studies demonstrate decreased meal‐related anxiety with residential or inpatient treatment, but less is known about changes in dietary variety and anxiety associated with specific foods. The current study assessed change in food anxiety and dietary variety in inpatients with EDs (anorexia nervosa and bulimia nervosa) in relation to discharge outcomes from meal‐based behavioral treatment.MethodPatients (N = 128) admitted to a specialized, hospital‐based behavioral treatment program completed measures of food anxiety, dietary variety, and ED symptoms at admission and discharge. Demographic and clinical data were abstracted from electronic medical records. A novel network community analysis identified three food anxiety groups: fruit‐veg, animal‐based, and carb‐based foods.ResultsHigh‐energy density combination foods were most anxiety‐provoking and most avoided. Food anxiety decreased, and dietary variety increased from admission to discharge. Reduction in food anxiety was associated with lower ED symptom scores and higher normative eating self‐efficacy at discharge. For animal‐based foods, increased dietary variety was associated with lower food anxiety at discharge. Neither variety nor anxiety was associated with weight restoration.DiscussionFindings highlight the importance of broadening dietary variety and targeting food anxiety during the nutritional rehabilitation and weight restoration phase of ED treatment. Increasing dietary variety may contribute to reduced food anxiety, which, in turn, may increase normative eating self‐efficacy. These results may help inform nutritional guidelines for meal‐based treatment programs.Public significanceConsuming a greater variety of foods during meal‐based intensive treatment may help alleviate food anxiety in patients with eating disorders.
Effects of temporal abiotic drivers on the dynamics of an allometric trophic network model
Authors: Eloranta Antti P. , Perälä Tommi , Kuparinen Anna 
Published: March 2023

AbstractCurrent ecological research and ecosystem management call for improved understanding of the abiotic drivers of community dynamics, including temperature effects on species interactions and biomass accumulation. Allometric trophic network (ATN) models, which simulate material (carbon) transfer in trophic networks from producers to consumers based on mass‐specific metabolic rates, provide an attractive framework to study consumer–resource interactions from organisms to ecosystems. However, the developed ATN models rarely consider temporal changes in some key abiotic drivers that affect, for example, consumer metabolism and producer growth. Here, we evaluate how temporal changes in carrying capacity and light‐dependent growth rate of producers and in temperature‐dependent mass‐specific metabolic rate of consumers affect ATN model dynamics, namely seasonal biomass accumulation, productivity, and standing stock biomass of different trophic guilds, including age‐structured fish communities. Our simulations of the pelagic Lake Constance food web indicated marked effects of temporally changing abiotic parameters on seasonal biomass accumulation of different guild groups, particularly among the lowest trophic levels (primary producers and invertebrates). While the adjustment of average irradiance had minor effect, increasing metabolic rate associated with 1–2°C temperature increase led to a marked decline of larval (0‐year age) fish biomass, but to a substantial biomass increase of 2‐ and 3‐year‐old fish that were not predated by ≥4‐year‐old top predator fish, European perch (Perca fluviatilis). However, when averaged across the 100 simulation years, the inclusion of seasonality in abiotic drivers caused only minor changes in standing stock biomasses and productivity of different trophic guilds. Our results demonstrate the potential of introducing seasonality in and adjusting the average values of abiotic ATN model parameters to simulate temporal fluctuations in food‐web dynamics, which is an important step in ATN model development aiming to, for example, assess potential future community‐level responses to ongoing environmental changes.
Seismic internal force in rocking shear frame with superelastic tendon restraint
Authors: Li Sheng , Tsang Hing‐Ho , Lam Nelson 
Published: March 2023

AbstractA structure with rocking mechanism is able to prolong the period of vibration and reduce seismic internal force. Recent research demonstrated the effectiveness of a tendon made of superelastic material wire connected in series with steel wire in controlling the amount of rotation and providing a source of hysteretic energy dissipation, thereby lowering the risk of overturning to a rigid structure undergoing whole‐body rotation. This article proposed to extend the use of superelastic tendon restraint on a (flexible) shear frame to strike a balance between the need to reduce the seismic force demand and the need to exercise control of the overturning risk. Initially, an analytical model for the rocking response of shear frame with the superelastic tendon restraint was developed. In addition, a physical model of the shear frame with tendon restraint was fabricated and tested under base excitations. Analysis results showed to match with experiment on both strain gauge and rotation sensor readings in the dynamic testing. Simulations and tests were also applied to an unrestrained shear frame for comparison. It was also found that the total deflection of the shear frame during the rocking phase could be described as horizontal vibration about a non‐constant balancing deflection. The analytical models developed for flexible rocking systems were extended in the current study to deal with superelastic tendon restrained rocking shear frames. The validity and versatility were confirmed by shaker table test results.
Lyophilized royal jelly preparation in nanoscale and evaluation of its physicochemical properties and bactericidal activity
Authors: Ghadimi‐Garjan Reza , Javadi Afshin , Jafarizadeh‐Malmiri Hoda , Anarjan Navideh , Mirzaei Hamid 
Published: March 2023

AbstractRoyal jelly, due to its unique bioactive components, has special biological activities, but a great extent of its nutritional value is lost during processing and storage. Lyophilization, an effective preservation technique, can feasibly preserve the main bioactive compounds present in royal jelly. In this study, fresh royal jelly was subjected to the freeze‐drying process at a pressure and temperature of 100 Pa and − 70°C, respectively, for 40 h. The results obtained indicated that the pH, turbidity, total phenol content, and antioxidant activity of the royal jelly powder (RJP), during 3 months of storage at ambient temperature (30°C), were constant with values of 4.30, 1.634 (%A.U.), 0.617 (g/L), and 28.7 (%), respectively. Moisture content of the prepared RJP was less than 1%, while that of the fresh royal jelly was 70%. Furthermore, for the fresh royal jelly, the mentioned parameters were significantly (p < .05) decreased after 2 months of storage at freezer temperature (−20°C). GC–MS analysis indicated that the amount of 10‐hydroxy‐2‐decanoic acid (10H2DA) in RJP was 3.85 times more than that of fresh royal jelly. The obtained results also indicated that prepared RJP had a high bactericidal effect toward Escherichia coli and Staphylococcus aureus, with clear zone diameters of 12 and 15 mm, respectively. The present study provides a foundation for research on the potential application of prepared RJP and the development of dietary supplements and functional foods.
Astrocyte structural heterogeneity in the mouse hippocampus
Authors: Viana João Filipe , Machado João Luís , Abreu Daniela Sofia , Veiga Alexandra , Barsanti Sara , Tavares Gabriela , Martins Manuella , Sardinha Vanessa Morais , Guerra‐Gomes Sónia , Domingos Cátia , Pauletti Alberto , Wahis Jérôme , Liu Chen , Calì Corrado , Henneberger Christian , Holt Matthew G. , Oliveira João Filipe 
Published: March 2023

AbstractAstrocytes are integral components of brain circuits, where they sense, process, and respond to surrounding activity, maintaining homeostasis and regulating synaptic transmission, the sum of which results in behavior modulation. These interactions are possible due to their complex morphology, composed of a tree‐like structure of processes to cover defined territories ramifying in a mesh‐like system of fine leaflets unresolved by conventional optic microscopy. While recent reports devoted more attention to leaflets and their dynamic interactions with synapses, our knowledge about the tree‐like “backbone” structure in physiological conditions is incomplete. Recent transcriptomic studies described astrocyte molecular diversity, suggesting structural heterogeneity in regions such as the hippocampus, which is crucial for cognitive and emotional behaviors. In this study, we carried out the structural analysis of astrocytes across the hippocampal subfields of Cornu Ammonis area 1 (CA1) and dentate gyrus in the dorsoventral axis. We found that astrocytes display heterogeneity across the hippocampal subfields, which is conserved along the dorsoventral axis. We further found that astrocytes appear to contribute in an exocytosis‐dependent manner to a signaling loop that maintains the backbone structure. These findings reveal astrocyte heterogeneity in the hippocampus, which appears to follow layer‐specific cues and depend on the neuro‐glial environment.
Multicenter retrospective study of the prognosis and the effect of postoperative adjuvant therapy in Japanese oral squamous cell carcinoma patients with close margin
Authors: Hasegawa Takumi , Kakei Yasumasa , Yamakawa Nobuhiro , Kirita Tadaaki , Okura Masaya , Naruse Tomofumi , Otsuru Mitsunobu , Yamada Shin‐ichi , Kurita Hiroshi , Hirai Eiji , Rin Shin , Ueda Michihiro , Umeda Masahiro , Akashi Masaya ,   Japan Oral Oncology Group (JOOG)
Published: March 2023

AbstractBackgroundThe purpose of this retrospective study was to investigate the prognosis of patients with oral cavity cancer with positive margin (PM) or close margin (CM) divided into pN− and pN+ groups.MethodsThe evaluated endpoints were local control and disease‐specific survival (DSS) rates.ResultsHigher T classification, lymphovascular space invasion (LVSI), and older age were significant risk factors for DSS in the pN− groups. On the other hand, extranodal extension, multiple lymph node metastases, and LVSI were significant risk factors for DSS in the pN+ groups. Among the CM pN+ patients, no significant differences in the 3‐year DSS were observed between the only surgery (51.9%) and adjuvant groups (53.2%).ConclusionsHigher T classification and LVSI are high‐risk features more than PM or CM in the pN− groups for DSS. However, further prospective studies are needed to demonstrate the usefulness of adjuvant treatment in patients with PM or CM.
Bioresponsive fluorescent probes active in the second near‐infrared window
Authors: Chen Yuqin , Chen Jie , Chang Baisong 
Published: March 2023

AbstractEmerging stimuli‐responsive composite probes active in the second near‐infrared window (NIR‐II, 1000–1700 nm) hold vast potential for improving in vivo imaging performance with minimized noise interference. The interactions among external irradiation, shell species, and the emissive core are key factors in the design of smart structures. The external irradiation provides energy for shell species and the emissive core to generate intense NIR‐II fluorescence signals, while the energy transfer process hinders NIR‐II emission in the inner structure of smart composite probes. However, if pathophysiological stimuli interrupt the above processes, then NIR‐II fluorescence signals are recovered. This review covers NIR‐II imaging based on diverse smart composite NIR‐II fluorescent probes responding to various biological stimuli, including ONOO−, overexpressed reactive sulfur species, abnormally expressed enzymes, and abnormal levels of physiological metabolites. Finally, to appreciate these advances, the challenges and perspectives of stimuli‐responsive composite NIR‐II probes are highlighted.
Novel synthesis method of oxygen vacancy WO3 and its photocatalytic performance for degradation of rhodamine B
Authors: Zhang Yu , Zheng Ming , Feng Yuan , Yu Zhichong , Wu Minghong , Tang Liang 
Published: March 2023

AbstractBACKGROUNDPhotocatalytic degradation of organic pollution as a ‘green’ treatment technology has been a broad concern in water treatment. This work proposed a simple method for introducing oxygen vacancies into WO3 and enhancing the degradation of WO3 for rhodamine B under simulated solar light.RESULTSIn this work, titanium power was used as an oxygen absorber to introduce oxygen vacancies into WO3. The degradation of organic dyes by semiconductor materials is significantly improved by the presence of oxygen vacancies. After 4 h of simulated sunlight irradiation, 100% degradation efficiency of rhodamine B by WO3 with vacancies was achieved, compared to about 60% by WO3. Combined with liquid chromatography–mass spectrometry and total organic carbon analysis results, we speculated the degradation path of rhodamine B degraded by WO3‐2.CONCLUSIONThere exist three reasons for the enhanced photocatalytic performance of oxygen‐containing vacancy WO3: (i) the introduction of vacancies generates an energy level of the donor that can reduce the band gap; (ii) the presence of oxygen vacancies can effectively prevent the electron–hole complexation process; and (iii) oxygen vacancies increase the adsorption capacity of the catalyst. It is expected that this method of oxygen vacancy introduction can be extended to other semiconductor systems to achieve higher performance in pollutant degradation and water remediation. © 2023 Society of Chemical Industry (SCI).