bluuebunny/crossref_metadata_2025_split huggingface dataset:
Twelve‐month results of the ADAPT randomized controlled trial: Reproducibility and sustainability of advanced hybrid closed‐loop therapy outcomes versus conventional therapy in adults with type 1 diabetes
Authors: Edd Shannon N. , Castañeda Javier , Choudhary Pratik , Kolassa Ralf , Keuthage Winfried , Kroeger Jens , Thivolet Charles , Evans Mark , Ré Roseline , Cellot Jessica , de Portu Simona , Vorrink Linda , Shin John , van den Heuvel Tim , Cohen Ohad ,   the ADAPT study Group
Published: August 2023

AbstractAimsTo reassess the 6‐month efficacy and to assess the 12‐month sustained efficacy of the MiniMed™ 780G advanced hybrid closed‐loop automated insulin delivery (AID) system compared to multiple daily injections plus intermittently scanned glucose monitoring (MDI+isCGM) in people with type 1 diabetes not meeting glucose targets.MethodsThe ADAPT study was a prospective, multicentre, open‐label, randomized control trial in people with type 1 diabetes, with a glycated haemoglobin (HbA1c) concentration of at least 8.0% (64 mmol/mol), on MDI+isCGM therapy. After a 6‐month study phase, participants randomized at baseline to MDI+isCGM switched to AID (SWITCH) while the others continued AID therapy (SUSTAIN) for an additional 6 months. The primary endpoint of this continuation phase was the within‐group change in mean HbA1c between 6 and 12 months, with superiority in the SWITCH group and noninferiority in the SUSTAIN group (ClinicalTrials.gov: NCT04235504).ResultsA total of 39 SWITCH and 36 SUSTAIN participants entered the continuation phase. In the SWITCH group, HbA1c was significantly decreased by −1.4% (95% confidence interval [CI] −1.7% to −1.1%; P < 0.001) from a mean ± SD of 8.9% ± 0.8% (73.9 ± 8.6 mmol/mol) at 6 months to 7.5% ± 0.6% (58.5 ± 6.9 mmol/mol) at 12 months. Mean HbA1c increased by 0.1% (95% CI −0.05% to +0.25%), from 7.3% ± 0.6% (56.5 ± 6.7 mmol/mol) to 7.4% ± 0.8% (57.7 ± 9.1 mmol/mol) in the SUSTAIN group, meeting noninferiority criteria. Three severe hypoglycaemia events occurred in two SWITCH participants during the continuation phase.ConclusionADAPT study phase glycaemic improvements were reproduced and sustained in the continuation phase, supporting the early adoption of AID therapy in people with type 1 diabetes not meeting glucose targets on MDI therapy.
Sleep hygiene behaviours mediate the association between health/e‐health literacy and mental wellbeing
Authors: Alijanzadeh Mehran , Yahaghi Rafat , Rahmani Jalal , Yazdi Nahid , Jafari Elahe , Alijani Hashem , Zamani Narges , Fotuhi Razie , Taherkhani Elham , Buchali Zeinab , Zarenejad Masoume , Mahmoudi Narges , Shahmahdi Najmeh , Poorzolfaghar Leila , Ahmadizade Safie , Shahbazkhania Azam , Gozal David , Lin Chung‐Ying , Pakpour Amir H. 
Published: August 2023

AbstractBackgroundHealth literacy and e‐health literacy are important factors helping people shape awareness of health behaviours in different aspects, including sleep hygiene behaviours. Good sleep hygiene behaviours promote sleep quality and are beneficial to overall mental wellbeing.ObjectiveWe aimed to examine if sleep hygiene behaviours may mediate the association between health literacy/e‐health literacy and mental wellbeing.MethodsAdult Iranian subjects (n = 9775; mean [SD] age = 36.44 [11.97] years; 67.3% females) completed the Health Literacy Instrument for Adults, eHealth Literacy Scale, three items on sleep hygiene behaviour that have been used in prior research and the Short Warwick Edinburgh Mental Wellbeing Scale. Data were then subjected to structural equation modelling (SEM) including 500 bootstrapping resampling to examine whether sleep hygiene is a mediator in the relationship between health literacy/e‐health literacy and mental wellbeing.FindingsBoth health literacy and e‐health literacy were significantly associated with mental wellbeing (r = .63 for health literacy and .39 for e‐health literacy; p < .001) and sleep hygiene behaviours (r = .58 for health literacy and .36 for e‐health literacy; p < .001). Sleep hygiene behaviours were significantly associated with mental wellbeing (r = .42; p < .001). Moreover, SEM that incorporated bootstrapping approaches indicated that sleep hygiene behaviours were significant mediators in the association between health literacy/e‐health literacy and mental wellbeing.ConclusionsWe conclude that health literacy and e‐health literacy are associated with mental health wellbeing in the Iranian population. Additionally, the association could be mediated via sleep hygiene behaviours.Patient or Public ContributionThe study was co‐designed with healthcare providers from the vice‐Chancellor's Office for Health Affairs of Qazvin University of Medical Sciences as equal partners. Moreover, the women's health volunteers were involved in the design of the study.
The application of infrared thermography technology in flap: A perspective from bibliometric and visual analysis
Authors: Lu Yilei , Sun Nianzhe , Wu Panfeng , Zhou Guoling , Peng Lingli , Tang Juyu 
Published: August 2023

AbstractThe application of infrared thermography technology (IRT) in flap has become a major focus of research, as it provides a non‐invasive, real‐time, and quantitative approach for monitoring flap perfusion. In this regard, we conducted a comprehensive visualization and scientometric analysis to systematically summarize and discuss the current state of research in this field. We systematically reviewed publications on the application of IRT in flap procedures from 1999 to 2022, using the Web of Science Core Collection (WoSCC). Through scientometric analysis, we examined annual trends, affiliations, countries, journals, authors, and their relationships, providing insights into current hotspots and future developments in this area. We analysed 522 English studies and found a steady increase in annual publications. The United States and Germany had the highest publication rates, with Beth Israel Deaconess Medical Center and Shanghai Jiaotong University being leading institutions. Notably, Lee BT and Alex Keller emerged as influential authors in this field. Compared to existing techniques, infrared‐based technology offers significant advantages for non‐invasive monitoring of flap perfusion, including simplicity of operation and objective results. Future trends should focus on interdisciplinary collaborations to develop new infrared devices and achieve intelligent image processing, enabling broader application in various clinical scenarios. This bibliometric study summarizes the progress and landscape of research on ‘the Application of infrared thermography technology in flap’ over the past two decades, providing valuable insights and serving as a reliable reference to drive further advancements and spark researchers' interest in this field.
Antibody targeting of mutant calreticulin in myeloproliferative neoplasms
Authors: Kramer Frederike , Mullally Ann 
Published: August 2023

AbstractMutations in calreticulin are one of the key disease‐initiating mutations in myeloproliferative neoplasms (MPN). In MPN, mutant calreticulin translates with a novel C‐terminus that leads to aberrant binding to the extracellular domain of the thrombopoietin receptor, MPL. This cell surface neoantigen has become an attractive target for immunological intervention. Here, we summarize recent advances in the development of mutant calreticulin targeting antibodies as a novel therapeutic approach in MPN.
Sonographic confirmation of placental detachment during placental delivery for uterine inversion prevention
Authors: Yonetani Naoto , Kaji Takashi , Shirakawa Aya , Sogawa Eishi , Yoshida Atsuko , Mineda Ayuka , Maeda Kazuhisa , Irahara Minoru , Iwasa Takeshi 
Published: August 2023

AbstractAimTo evaluate the usefulness of transabdominal sonographic confirmation of placental detachment in preventing uterine inversion.MethodsThis was 14‐year retrospective cohort study that included women who had transvaginal deliveries in our hospital. We introduced routine transabdominal ultrasonography during placental delivery to prevent uterine inversion. Followed by the confirmation of placental detachment by ultrasonography, we started placental delivery procedure. The frequency of uterine inversion during placental delivery was compared before and after the ultrasonography was introduced. Moreover, the duration of the third stage of labor and bleeding volume during labor were compared between the ultrasonography performing group (USG group) and the non‐performing group (non‐USG groups).ResultsFive thousand and eighty‐one women, including 1724 and 3357 women who delivered before and after the ultrasonography was introduced, respectively. The frequency of uterine inversion after the introduction of the ultrasonography system was significantly reduced compared to that before the introduction (0.03% vs. 0.23%, p = 0.03). Even after the introduction of ultrasonography, the actual rate of performing ultrasonography remained 54.1% due to various restrictions. The mean duration of the third stage of labor in the USG group was slightly longer than that in the non‐USG group (8.4 ± 5.0 vs. 6.8 ± 3.6, p < 0.01). The mean bleeding volume during labor in the USG group was higher compared with the non‐USG group (457 ± 329 vs. 418 ± 285, p < 0.01).ConclusionsTransabdominal sonographic confirmation of placental detachment may be useful in preventing uterine inversion.
Effect of glucocorticoids on the development of COVID‐19‐associated pulmonary aspergillosis: A meta‐analysis of 21 studies and 5174 patients
Authors: Hashim Zia , Nath Alok , Khan Ajmal , Gupta Mansi , Kumar Anup , Chatterjee Riksoam , Dhiman Radha Krishan , Hoenigl Martin , Tripathy Naresh Kumar 
Published: August 2023

AbstractCOVID‐19‐associated pulmonary aspergillosis (CAPA) remains a high mortality mycotic infection throughout the pandemic, and glucocorticoids (GC) may be its root cause. Our aim was to evaluate the effect of systemic GC treatment on the development of CAPA. We systematically searched the PubMed, Google Scholar, Scopus and Embase databases to collect eligible studies published until 31 December 2022. The pooled outcome of CAPA development was calculated as the log odds ratio (LOR) with 95% confidence intervals (CI) using a random effect model. A total of 21 studies with 5174 patients were included. Of these, 20 studies with 4675 patients consisting of 2565 treated with GC but without other immunomodulators (GC group) and 2110 treated without GC or other immunomodulators (controls) were analysed. The pooled LOR of CAPA development was higher for the GC group than for the controls (0.54; 95% CI: 0.22, 0.86; p < .01). In the subgroups, the pooled LOR was higher for high‐dose GC (0.90; 95% CI: 0.17, 1.62: p = .01) and dexamethasone (0.71; 95% CI: 0.35, 1.07; p < .01) but had no significant difference for low‐dose GC (0.41; 95% CI: −0.07, 0.89; p = .09), and non‐dexamethasone GC (0.21; 95% CI: −0.36, 0.79; p = .47), treated patients versus controls. GC treatment increases the risk of CAPA development, and this risk is particularly associated with the use of high‐dose GC or dexamethasone treatment.
Y a‐t‐il un avenir après la crise climatique ? De La fantastique Odyssée de Chérif Arbouz
Authors: Malinowska Magdalena 
Published: August 2023

RésuméLa crise climatique devient de plus en plus souvent le sujet des œuvres de fiction, non seulement dans l'aire culturelle anglo‐saxonne. Le présent article soumet à l'analyse un exemple de fiction climatique postcoloniale francophone, à savoir La fantastique Odyssée de l'Algérien Chérif Arbouz, dans le but de reconstruire la vision du futur y proposée. L'étude des procédés littéraires engagés par l'auteur tels que le héros collectif, l'étendue spatiale et temporelle de l'intrigue, l'insertion des passages essayistiques et scientifiques, démontre que l'écrivain arrive à représenter habilement la crise climatique et ses conséquences, à avertir les lecteurs des dangers y liés, de même qu'à faire partie du débat mondial concernant le futur de notre planète.
Utilization of donor‐derived Cell‐Free DNA in pediatric kidney transplant recipients: A single center study
Authors: Ranch Daniel , Fei Mingwei , Kincade Elisabeth , Piburn Kim , Hitchman Kelley , Klein Kelsey 
Published: August 2023

AbstractHigh donor‐derived cell‐free DNA (dd‐cfDNA) levels indicate transplant allograft injury and can identify graft rejection in kidney transplant recipients. Here, we evaluated the use of dd‐cfDNA in pediatric kidney transplant rejection monitoring and treatment.MethodsForty‐two pediatric kidney transplant patients were enrolled between February 2020 and August 2021. Dd‐cfDNA was tested before and after biopsy/rejection treatment. There was a total of 61 allograft biopsies (44 for‐cause, 17 surveillance).ResultsGraft rejection was found in 35/61 biopsies. Rejection was more common in basiliximab induction compared to rATG (77.1% vs. 22.9%, p = .0121). Median dd‐cfDNA was higher in those with rejection (1.2% [0.34–3.12] vs. 0.24% [0.08–0.78], p < .0001). Dd‐cfDNA was highest in biopsies with AMR and mixed AMR/TCMR. In addition, dd‐cfDNA in basiliximab induction was higher compared to rATG (0.92% [0.27–1.8] vs. 0.26% [0.08–2], p = .0437). Median change in dd‐cfDNA after rejection treatment was −0.57% (−1.67 to 0.05). Median time to dd‐cfDNA <1% post‐rejection treatment was 8.5 days (3.0–19.5). Dd‐cfDNA in AMR was higher compared to TCMR or mixed rejection, and levels remained higher in AMR after treatment. In surveillance biopsies, 4/17 had rejection. Median dd‐cfDNA was not different in those with versus without rejection (0.48% vs. 0.28%, p = .2342). Those without rejection all had dd‐cfDNA <1%. In those with rejection, only one patient had dd‐cfDNA >1%, and all had TCMR.ConclusionsOur findings support dd‐cfDNA as a useful indicator of graft rejection and response to treatment. Additional studies are needed to determine the role of dd‐cfDNA in graft health surveillance.
When the context withholds girls from gender a‐typical conduct: Schools' gender role culture and disruptive school behaviour of boys and girls
Authors: Van Houtte Mieke 
Published: August 2023

AbstractOn average, boys display more disruptive school behaviour than girls. This study looks at this behaviour in the first place as gendered behaviour, investigating whether boys' and girls' disruptive behaviour is associated with their schools' student and teacher gender role culture. Multilevel analyses (HLM7) of representative Flemish data of 2706 male and 2436 female 8th grade students in resp. 57 and 49 secondary schools, and 1247 teachers gathered at the end of school‐year 2013/14, revealed that a more traditional student gender role culture is associated with less disruptive school behaviour in girls. As for boys, the positive association between traditional student gender role culture and disruptive school behaviour disappears when accounting for their individual gender role attitudes, which are significantly more traditional than those of girls. More traditional gender role attitudes coincide with more disruptive behaviour in boys and girls. Moreover, boys displaying less disruptive behaviour report a higher felt pressure for gender conformity. No impact is found of the homogeneity of teachers' gender role attitudes. The findings demonstrate that disruptive school behaviour can be looked at as gendered behaviour and can be tackled, at least partly, by discouraging gender stereotypical beliefs in students.
The mechanisms related to fibroblasts in burn surface
Authors: Zhang Gaofei , Li Jiamei , Wang Di , Lou Hanxiao , Zhang Chenying , Liu Wenjun 
Published: August 2023

AbstractPurposeMesenchymal stem cells (MSCs) can promote burn wound healing, skin appearance, and function recovery by promoting the differentiation and migration of fibroblasts of a wound. The burn environment can activate the autophagy of MSCs. However, it is not clear whether this autophagy can affect the proliferation and migration of fibroblasts.MethodsIn this study, pretreated MSCs with rapamycin and 3‐methyladenine modulated autophagy and co‐cultured with fibroblasts of burn. Cell migration was detected by immunofluorescence chemical staining. Western blot analysis and enzyme‐linked immunosorbent assay were performed to detect 2,3‐Dioxygenase (IDO), cytokine synthesis inhibitory factor 10 (IL‐10), cytokine synthesis inhibitory factor 6 (IL‐6), prostaglandin E2 (PGE2), transforming growth factor beta 1 (TGF‐β1) proteins levels, and the autophagy proteins p62 and microtubule‐associated protein LC3‐II/I.ResultsWe demonstrated that autophagy regulates MSCs survival and proliferation in burn wound transplants and found that autophagy inhibition with 3‐methyladenine reduced MSCs‐mediated, fibroblast proliferation and migration in burn environment. However, rapamycin‐induced autophagy had the opposite effect and increased the TGF‐β1 expression. Therefore, we speculate that MSCs may promote fibroblast proliferation and migration by secreting TGF‐β1 via the AKT/mTOR (RAC‐alpha serine/threonine‐protein kinase/mammalian target of rapamycin) pathway.ConclusionAutophagy of MSCs regulates burn wound fibroblast proliferation and migration by affecting TGF‐β1 and prostaglandin E2 production adjacent to MSCs transplanted on the burn wound. The results of this study provide a potential strategy for promoting MSCs treatment of burns.
Ward round communication with older patients
Authors: Andersen Lene Holst , Jensen Rune Dall , Skipper Mads , Lietzen Lone Winther , Krogh Kristian , Løfgren Bo 
Published: August 2023

AbstractObjectivesWard round communication is essential to patient care. While communication in general with older patients is well described, little is known about how communication with older patients and their relatives at ward rounds can be optimised. Hence, this scoping review aims to provide an overview of ward round communication with older patients. Furthermore, the review investigates barriers to the optimal communication. Such an overview would provide a point of departure for developing future health care professionals' education in ward round communication training.MethodA scoping review was performed by searching CINAHL, Embase, MEDLINE, and PubMed databases. The search strategy included terms synonymous with “ward rounds” and “older patients.” We included studies regarding communication with patients above 65 years during ward rounds. Thematic analysis was applied.ResultsSeven of the 2322 identified papers were included in the present review. Thematic analysis revealed three overall themes: Communication strategy, frailty and patient participation, and organisational and age norm challenges. Barriers included frailty‐related patient characteristics and imbalance of power between physicians and patients. Papers focused mainly on what the optimal ward round communication should include rather than how it should be performed.ConclusionCharacteristics of frail older patients and organisational barriers challenge effective and safe ward round communication. Little is known about how ward round communication with frail older patients and their relatives can be optimised.
Evaluation of bacterial growth, effects on albumin, and coagulation factors in canine fresh frozen plasma administered as continuous rate infusion exposed to room temperature for 12 hours
Authors: Mesa‐Sanchez Ignacio , Ferreira Rui R. F. , Blasi‐Brugué Carles , de Gopegui Rafael R. , de Matos Augusto J. F. 
Published: August 2023

AbstractObjectivesTo determine the risk of bacterial growth and to analyze the stability of albumin and coagulation factors in canine fresh frozen plasma (FFP) units exposed to room temperature (24°C) administered as a continuous rate infusion (CRI) for 12 hours.DesignEx vivo study.SettingUniversity teaching hospital and pet blood bank.AnimalsNone.InterventionsNone.Measurements and Main ResultsAn FFP CRI was simulated to replicate the standard routine procedure used in dogs. Plasma samples were collected before starting the CRI (H0), after 4 hours (H4), and after 12 hours (H12). Bacterial culture of FFP was performed and albumin concentration and specific activity levels for factors V, VII, VIII, and IX were measured and compared. All plasma culture results were negative. There were no statistically significant differences at any time point in the factor VIII activity (median 105.5% [range, 75.6%–142.0%] at H0; median 107.8% [range, 75.0%–172.7%] at H4; and median 112.1% [range, 81.7%–171.0%] at H12); factor IX activity (median 119.3% [range, 89.1%–175.9%] at H0; median 123.1% [range, 72.5%–172.7%] at H4; and median 118.3% [range, 86.6%–177.5%] at H12); or albumin concentration (median 21.0 g/L [range, 17.0–23.0 g/L] at H0 and median 20.0 g/L [range, 17.0–24.0 g/L] at H12). A slight but significant increase in factor V activity was observed when comparing H0 (median 107.0% [range, 71.0%–159.0%]) to H4 (median 117.7% [range, 71.0%–176.7%]) (P = 0.002) or H12 (median 116.2% [range, 71.0%–191.6%]) (P = 0.001). A slight but significant increase in factor VII activity was observed when comparing H0 (median 115.4% [range, 70.6%–183.7%]) to H4 (median 118.2% [range, 82.7%–194.6%]) (P = 0.005); H0 to H12 (median 128.7% [range, 86.4%–200.0%]) (P < 0.001); and H4 to H12 (P = 0.002).ConclusionsFFP CRI at room temperature for 12 hours could be considered safe with regard to risk for bacterial growth and also effective by providing albumin and clotting factors.
The indigenization of Ghanaian Pidgin English
Authors: Yakpo Kofi 
Published: August 2023

AbstractIn the world Englishes literature, ‘indigenization’ is shorthand for the localization of Outer Circle Englishes in former exploitation colonies like Ghana. However, the localization of Ghanaian English has been continually reversed by ‘corrective’ realignment with world standard English through institutional regimes. By contrast, the localization of Ghanaian Pidgin English has proceeded unhampered by standardization. This article provides a first analysis of the copula system of Ghanaian Pidgin English, showing that it owes much to patterns found in Akan and other languages of southern Ghana. In this domain, Ghanaian Pidgin English has indigenized and differentiated itself from its sister languages. I propose a consistent and expansive definition of indigenization as ‘the areal alignment of a latecomer with a linguistic ecology, causing its divergence from related varieties elsewhere.’ This study of indigenization shifts the focus from standardized Englishes to contact Englishes. The latter remain unfettered by institutional intervention and are therefore better suited to illustrating the natural dynamics of indigenization than standardized Englishes.