bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencia del uso de la tecnología en el aprendizaje de los estudiantes de bachillerato
Authors: Machuca Toapanta Sandra Jacqueline , Cuadros García Paquita Alejandra , Herrera Sarango Víctor Fernando , Alejandro Becerra Jessica Pilar , Sancho López Cristian Stalin 
Published: March 2023

Muchos autores han destacado que los docentes para fortalecer el aprendizaje de sus alumnos usan estrategias analíticas y creativas, siendo las Tics una herramienta que potencia ambos aspectos, es relevante realizar un análisis dentro de la educación a nivel de Bachillerato haciendo énfasis con un antes y un después de la pandemia del COVID-19.
En la actualidad, con los avances de las tecnologías de información y comunicación, según (Ocaña, Valenzuela, & Morillo, 2020), las opciones didácticas y pedagógicas tienen un mayor impacto en contraste con la educación tradicional, para lo cual se plantea una investigación cuyo objetivo es determinar el grado de influencia del uso de la tecnología en el aprendizaje de los estudiantes con un caso de estudio aplicado en el “Colegio Bachillerato Huaquillas”.
Esta investigación se desarrolló con un enfoque cuantitativo de tipo exploratorio, donde se muestra un incremento del 0,80% en el rendimiento académico para los estudiantes del “Colegio Bachillerato Huaquillas”, lo que significa que existe una influencia positiva en el aprendizaje de los estudiantes.
Anemia hemolítica autoinmune mixta en adulto mayor post infección por sars-cov-2. Reporte de caso
Authors: Lopez Muñoz Diego Fernando , Medina González Manuel Iván , Guagua Cabezas Daniel Felipe , Paredes Polanco Manuel Alejandro 
Published: March 2023

Masculino 76 años, antecedente previo de SARS-CoV-2, requirió hospitalización. Ingresa al servicio de urgencias por cuadro clínico caracterizado por dificultad para respirar, dolor abdominal, síntomas urinarios y edema periférico. Signos vitales: Temperatura 38°C, FR 26 rpm, FC 100 lpm, PA 128/63 mmHg, SPO2 85%, FiO2 21%. Exploración Física: consciente y orientado en tiempo, lugar y persona. Exploración física: Palidez cutánea e ictericia en escleras. Abdomen blando, depresible y doloroso a la palpación en ambos cuadrantes superiores y marcada hepatoesplenomegalia. Paraclínicos: hemograma reporta anemia macrocítica, hipercrómica, con recuento bajo de glóbulos rojos, leucopenia y plaquetas normales en cantidad. ESP: reporta policromasia +++, esferocitos ++, células nucleadas rojas 20 en 100 células blancas contadas, aglutinación ++. Prueba de coombs directa positiva 4+. Hiperbilirrubinemia a expensas de la indirecta y elevación de la LDH y creatinina sérica 2,8 mg/dL, BUN 40 mg/dL. Derivado a UCI con diagnósticos presuntivos de AHAI, IRA. ITU, donde es manejado con corticoides endovenosos y medicamentos inmunomoduladores. Se conoce poco del mimetismo molecular del virus, según referentes bibliográficos utiliza proteínas de membrana celular para entrar al glóbulo en forma de hapteno y generar una respuesta inmune errada.
First Observation of Chromospheric Waves in a Sunspot by DKIST/ViSP: The Anatomy of an Umbral Flash
Authors: French Ryan J. , Bogdan Thomas J. , Casini Roberto , de Wijn Alfred G. , Judge Philip G. 
Published: March 2023

Abstract
The Visible Spectro-Polarimeter of the NSF Daniel K. Inouye Solar Telescope collected its Science Verification data on 2021 May 7–8. The instrument observed multiple layers of a sunspot atmosphere simultaneously, in passbands of Ca ii 397 nm (H line), Fe i 630 nm, and Ca ii 854 nm, scanning the region with a spatial sampling of 0.″041 and an average temporal cadence of 7.76 s, for a duration of 38.8 minutes. The slit moved southward across the plane of sky at 3.83 km s−1. The spectropolarimetric scans exhibit prominent oscillatory “ridge” structures that lie nearly perpendicular to the direction of slit motion (north to south). These ridges are visible in the maps of line intensity, central wavelength, line width, and both linear and circular polarization. Contemporaneous Atmospheric Imaging Assembly observations indicate that these ridges are purely temporal in character and are likely attributed to the familiar chromospheric 3 minute umbral oscillations. We observe in detail a steady umbral flash near the center of the sunspot umbra. Although bad seeing limited the spatial resolution, the unique high signal-to-noise ratio data enable us to estimate the shock Mach numbers (≈2), propagation speeds (≈9 km s−1), and their impacts on the longitudinal magnetic field (ΔB ≈ 50 G), gas pressure, and temperature (ΔT/T ≈ 0.1) of subshocks over 30 s. We also find evidence for rarefaction waves situated between neighboring wave train shocks. The Ca ii 854 nm line width is fairly steady throughout the umbral flash, except for a sharp 1.5 km s−1 dip immediately before, and a comparable spike immediately after, the passage of the shock front. This zigzag in line width is centered on the subshock and extends over 0.″4.
Gravitational Wave Source Populations: Disentangling an AGN Component
Authors: Gayathri V. , Wysocki Daniel , Yang Y. , Delfavero Vera , O’Shaughnessy R. , Haiman Z. , Tagawa H. , Bartos I. 
Published: March 2023

Abstract
The astrophysical origin of over 90 compact binary mergers discovered by the LIGO and Virgo gravitational wave observatories is an open question. While the unusual mass and spin of some of the discovered objects constrain progenitor scenarios, the observed mergers are consistent with multiple interpretations. A promising approach to solve this question is to consider the observed distributions of binary properties and compare them to expectations from different origin scenarios. Here we describe a new hierarchical population analysis framework to assess the relative contribution of different formation channels simultaneously. For this study we considered binary formation in active galactic nucleus (AGN) disks along with phenomenological models, but the same framework can be extended to other models. We find that high-mass and high-mass-ratio binaries appear more likely to have an AGN origin compared to having the same origin as lower-mass events. Future observations of high-mass black hole mergers could further disentangle the AGN component from other channels.
Partir : mobilités résidentielles et conditions de logement en France pendant l’épidémie de Covid-19
Authors: Le Roux Guillaume , Lambert Anne , Bonvalet Catherine , Baril Élodie , Bringé Arnaud , Bajos Nathalie 
Published: March 2023

Au printemps 2020, un confinement national a été décrété en France pour lutter contre l’épidémie de Covid-19 – le plus long et le plus strict jusqu’à ce jour. Celui-ci a entraîné des mouvements spontanés de populations, largement médiatisés autour de la figure de l’exode urbain des Parisiens. Mais les départs des grandes villes vers les campagnes ont-ils été les seuls types de mobilité pendant cette période ? Et que nous apprennent en retour les mobilités de confinement sur les pratiques résidentielles et conditions de logement ordinaires des ménages, ainsi que sur les ressources mobilisées pour faire face à ces situations exceptionnelles ? À partir de l’enquête EpiCOV (Inserm-Drees) conduite en France auprès d’un échantillon de 135 000 personnes de 15 ans et plus à la fin du premier confinement, cet article analyse les différents types de mobilités résidentielles sur le territoire français au printemps 2020. Sans pouvoir présager du caractère durable ou non de ces mobilités, ni de leur répétition au cours des différentes phases de confinement, l’analyse souligne l’hétérogénéité des pratiques de mobilités, saisies ici en termes de distance parcourue, d’évolutions de gradient d’espace urbain, de type et conditions de logement, ainsi que la variété des ressources mobilisées selon le sexe, l’âge et la position sociale des individus. Si les mobilités de longue distance concernent plus souvent des populations aisées, les déplacements de proximité sont quasiment aussi fréquents et concernent des fractions plus hétérogènes de la population.
Role of Wnt Ligand Secretion Mediator Signaling in Cancer Development
Authors: Chuang Kai-Ting , Wang Li-Ting , Hsu Shih-Hsien 
Published: March 2023

Objective:
The Wnt signaling pathway is among the crucial cascades that regulate development and homeostasis of tissue.

Data Sources:
Further, it is closely associated with different types of cancer, which includes glioma, breast, colorectal, lung, and prostate cancer, and hepatocellular carcinoma (HCC). The deviant activation or inhibition of Wnt signaling regulates cancer progression, thereby exerting oncogenic or tumorsuppressive effects that control the invasion, metastasis, and metabolism of cancer cell.

Study Selection:
In the Wnt secretory pathway, lipidmodified Wnt molecules interact with Wnt ligand secretion mediator (WLS), a Wnt cargo receptor. Moreover, they are directed to the plasma membrane and then secreted.

Results:
Loss of WLS function leads to the accumulation of Wnt in the endoplasmic reticulum (ER), leading to retrograde Golgi–ER transport and ER stress associated with the pathogenesis of several conditions, including early embryonic death, and developmental defects related to lymphopoiesis, neurogenesis, and osteogenesis in adults. Although there is substantial evidence, the regulatory mechanisms through which WLS controls cellular functions are not fully elucidated.

Conclusion:
Therefore, the current study aimed to identify the underlying mechanism of the effects of WLS on the development of human diseases.
Antibacterial impact of nonthermal atmospheric plasma on catheter-based biofilms of Staphylococcus epidermidis and Klebsiella pneumoniae isolated from small ruminants in vivo
Authors: Syame Sohier M. , Lotfy Khaled , Abdel-Razik Ahmed M. , Elgabry Elgabry Abd-Elalim , Abouelhag Hussien A. , Fouad Ehab A. , Hakim Ashraf S. 
Published: March 2023

Background
Nonthermal atmospheric pressure sterilization is one of the suggested and efficient techniques to hinder the spread of illnesses. Reactive species such as oxygen, hydroxyl, and other radicals play a prime role in the mechanism of plasma sterilization. Staphylococcus epidermidis is the most prevalent cause of primary bacteremia and infections of indwelling medical instruments. The ability to induce disease is related to its natural niche on the skin and capability to adhere and form a biofilm on foreign surfaces. Klebsiella pneumoniae is a zoonotic pathogen frequently isolated from infections related to the presence of bacterial biofilm on devices, such as catheters, which are responsible for loss of patients’ health.

Objective

S. epidermidis and K. pneumoniae are being combated due to their high frequency of occurrence and ability to form biofilms as survival and virulence characteristics. These particular benefits impose a significant financial burden on hospitals.

Materials and methods
In this study, the nonthermal plasma treatment induced by surface dielectric-barrier discharge was used to destruct the developed biofilm formed by clinical S. epidermidis and K. pneumoniae isolated from clinical cases of small ruminants. The biofilms were induced in vivo by catheter-based rat model preparation. The biofilms were examined before and after the treatment using a scanning electron microscope.

Results and conclusion
The produced nonthermal plasma degenerated and reduced the number of adherent and aggregated viable bacteria.
Remarkable improvement of levansucrase production from a newly isolated Aspergillus niger MK788296 strain using agro-industrial wastes through statistical optimization techniques
Authors: Elzairy Nermeen H. , Mostafa Faten A. , Wahab Walaa A. Abdel , Abdel-Naby Mohamed A. , Ragab Yasser M. , Hashem Abdelgawad M. 
Published: March 2023

Background and objectiveMicrobial levansucrase (LS) is a good source for the production of biologically active fructo-oligosaccharides and levan, which have diverse applications in pharmaceutical industries. Therefore, recent studies have focused on the enhancement of LS production through searching for potent microbial producers and optimization of the fermentation conditions. The present study aimed to use agro-industrial waste as a cost-effective carbon source for LS production and maximize the enzyme yield by optimization of the cultural conditions.Materials and methodsA potent fungal producer of LS was isolated from an Egyptian soil sample that was collected from Giza Governorate at a depth of 5 cm and identified based on internal transcribed spacer identification and then submitted to the gene bank database. The production of LS by the isolated strain was optimized by evaluating the best fermentation state and agro-industrial waste to be used in the fermentation process. After that, further optimization of culture medium composition was established by two statistical designs: the Plackett–Burman design followed by central composite design.Results and conclusionThe isolated strain was identified asAspergillus nigerMK788296. The first optimization approach declared that using the submerged fermentation technique and utilizing potato peels as the main carbon source led to a 2.4-fold increase in LS production. The statistical optimization resulted in a massive LS production (18870.3 U/ml) with a 59.4-fold increase in enzyme yield than the nonoptimized culture conditions.
Detection and molecular characterization of lipase-producing bacteria
Authors: Alhebshi Alawiah , Al-Sayied Fadwa S. , El-Hamshary Ola I.M. 
Published: March 2023

Background
Lipase is a type of hydrolytic enzyme that has several applications and industrial efforts. Lipases are used as biological catalysts to manufacture products such as food ingredients and applied in making fine chemicals. The type of lipase produced from microbes, mainly from bacteria and fungi, represents the most widely used class of enzymes in biotechnological applications and organic chemistry. Microbial enzymes are also more stable than their corresponding plant and animal enzymes, and their production is more convenient and safer, which makes them more important in commercial uses. The oily environment of vegetable oil-processing factories, industrial wastes, soil contaminated with oil, and diesel fuel-polluted soil provides a suitable habitat for lipase-producing microorganisms.

Objective
This study aims to detect new strains of lipase-producing bacteria from diverse sources and different areas in Jeddah, Saudi Arabia. Furthermore, the detected bacterial strains have been identified based on morphological, biochemical, and molecular characterization. The plasmid profile of some isolated bacterial strains has been detected.

Materials and methods
A total of 36 soil samples contaminated with fuel and engine oil were collected from different areas in Jeddah, Saudi Arabia. Tween 20 medium was used to detect the lipolytic activity of the bacterial strains. The isolated bacteria in this study were identified by morphological and biochemical tests and 16SrRNA.

Results and discussion
Results showed that 53 isolates were positive and able to produce lipase, and 15 isolates have been selected as strong lipase-producing bacteria. The sequences were submitted to the NCBI GenBank under accession numbers, accession numbers, ON360988.1 for Acinetobacter sp.
(FS5), ON360990.1 for Alcaligenes faecalis
(FS8), ON360991.1 for Acinetobacter baumannii
(FS9), ON360992.1 for Bacillus tropicus (FS10), ON360993.1 for A. baumannii
(FS11), ON360994.1 for Sphingomonas aeria
(FS15), and ON360996.1 for A. baumannii
(FS17). Plasmids were isolated from selected strains that showed lipase production using a plasmid-isolation miniprep. Results indicated that isolates FS6 and FS15 have no plasmids, whereas FS8 has one plasmid (≈1295.5 bp). Furthermore, isolates FS10 and FS11 have two plasmids (≈1539.3 and 1295.5 bp). In addition, isolate FS9 has three plasmids (≈1539.3, 1295.5, and 417.7 bp). The isolates showed strong lipase activity and could be good sources for the production of lipase.
A Correlational Study to Assess the Level of Perception and Exercise Barriers among People with Type 2 Diabetes Mellitus
Authors: Sarika M. L. , Chakraborty Srijita , Panda Payel 
Published: March 2023

Introduction:
The burden of diabetes mellitus (DM) is gradually increasing globally and in developing countries like India. According to the International Diabetes Federation 2019 report, around 77 million people in India are diagnosed with diabetes with a projected increase to 34 million by 2045. Appropriate implementation and practice of lifestyle measures like exercise plays a key role as a supporting factor in effective diabetes management. The main objective of the study was to determine the relation between the exercise barriers and level of disease perception on the disease among people with diabetes.

Methodology:
This is a correlational descriptive study conducted among patients with type 2 DM (T2DM), who are attendees of the medicine outpatient department of a tertiary care hospital in Bhubaneswar. The samples were selected through purposive sampling technique. A self-structured sociodemographic profile, Standardized Appraisal of Diabetes Scale, and Personal Diabetes Questionnaire were used to collect data from the participants.

Results:
The results showed that male (77 [60.2%] among the 128) patients are more susceptible to DM than the females. Majority of the study cohort had a negative appraisal on the DM with a mean value of 17.98 (standard deviation [SD] =1.29). While considering the exercise barriers, the majority of the patients had more exercise barriers with a high mean of 36.77 (SD = 1.04). Here, the correlation between the exercise barrier and level of perception shows a nonsignificant weak negative correlation. The cohort reported that their nonsupportive family and friends are the major exercise barriers with a mean value of 6.

Conclusion:
Exercise, together with medical nutrition therapy, forms the cornerstone of diabetes therapy. The study results identified a lot of barriers among patients with diabetes that hinders exercise in daily life, and it had a significant association with the diabetes control.
Apneic anesthesia with THRIVE for pediatric bronchial foreign body removal
Authors: Harde Minal J. , Kamble Trupti , Ramchandani Pooja 
Published: March 2023

ABSTRACT
Anesthesia for impacted tracheobronchial foreign body (FB) removal in pediatrics is challenging owing to shared airway, need of tubeless apneic anesthesia, and higher risk of airway complications. Transnasal humidified rapid insufflation ventilatory exchange (THRIVE) has unique applications for apneic anesthesia. The authors describe two pediatric cases of impacted lower bronchial FB that were difficult to retrieve and required long procedure time. They were done successfully under apneic anesthesia using THRIVE that provided intermittent total apnea of 58 and 62 min, respectively, with single-continuous apnea time of 13–18 min. THRIVE facilitated the procedure by providing a safe long apnea time without desaturation and with permissible increase in PaCo2 while maintaining hemodynamic parameters and oxygenation.
Case series on use of intrathecal morphine in pediatric thoracic spine surgeries
Authors: Singh Ranju , Yadav Ayushi , Varshney Preeti G. 
Published: March 2023

ABSTRACT
Intrathecal morphine is a very good analgesic agent and was used frequently in the past. Its use has decreased over the years due to side effects such as respiratory depression, nausea, vomiting, pruritis, and so on. Also, with the introduction of drugs like clonidine and the availability of ultrasonography for regional blocks, the role of morphine has declined. Yet, there are surgeries where intrathecal morphine supersedes all other analgesic modalities to provide excellent intraoperative and postoperative analgesia.
Efficacy and safety of oral tizanidine premedication as pre-emptive analgesia in adult patients undergoing elective surgeries- A systematic review
Authors: Nair Abhijit , Rangaiah Manamohan , Borkar Nitin 
Published: March 2023

ABSTRACT
Tizanidine is a centrally acting α2 agonist which has been used as a premedication due to its opioid-sparing and sympatholytic properties. This systematic review assessed the safety and feasibility of oral tizanidine. After registering the protocol with PROSPERO (CRD42022368546), randomized controlled trials and non-randomized observational studies were searched in various databases. The primary outcome was intraoperative opioid use; the secondary outcomes were 24-hr opioid consumption, pain scores, time to rescue analgesia, and adverse events. The risk of bias scale was used to assess the quality of evidence. Out of 202 studies identified, five studies fulfilled the inclusion criteria. Intraoperative opioid consumption was significantly less in the tizanidine group (MD: -2.40; 95% CI: -4.22, -0.59; P = 0.010; I2 = 0 %). The 24-hr opioid consumption was comparable between both groups (MD: -42.53, 95% CI: -91.45, 6.39; P = 0.09; I2 = 99%). Time to rescue analgesia was comparable between both groups (MD: 308.22; 95% CI: -263.67, 880.11, P = 0.29, I2 = 100%). Pain scores at 6 and 12 hours were comparable (MD: -1.37; 95% CI: -3.68, 0.94; P = 0.24; I2 = 97%) and (MD: -1.76; 95% CI: -4.06, 0.53; P = 0.13; I2 = 95%); however, at 24 hours the scores were better in the tizanidine group (MD: -1.10; 95% CI: -1.50, -0.69; P < 0.0001 I2 = 0%). Although dry mouth was significantly more in the tizanidine group (MD: 5.35; 95% CI: 1.72, 16.62; P = 0.004; I2 = 0%), postoperative nausea/vomiting and dizziness were comparable. Tizanidine reduces intraoperative opioid consumption without significant adverse events. However, it does not provide effective opioid-sparing analgesia or reduced opioid requirement in the first 24 hours after surgery.
MONITORING THE PRESENCE OF SYSTEMIC PATHOGENS IN PLANTATIONS OF HORTICULTURAL CROPS IN AZERBAIJAN
Authors: KURBANOV I. S. , ABDULLAEV E. , KUKHARCHIK N. V. , KASTRITSKAYA M. S. 
Published: March 2023

A visual evaluation of plantations of apple, pear, quince, cherry, sweet cherry, hexaploid plum, diploid plum, apricot,
peach, nectarine, almond, hazelnut, pomegranate, fig, tea, carried out in 2021, made it possible to identify a wide range
of symptoms of viral, phytoplasmic and bacterial infections. Primary diagnosis was carried out in the fruit-bearing and
collection orchards and nurseries of the Absheron, Ganja-Gazakh, Sheki-Zakatal, Lenkoran, Guba-Khachmaz, Aran regions.
It was noted that the symptoms of viral pathogens are present both in age and 3–5-year-old plantations planted with
imported landing material. Symptoms of viral and other systemic diseases were not identified in modern plantings of almonds
in any of the regions, as well as in a few examined plantings of pomegranate, figs, and tea.
THE ANNUAL CYCLE OF DIFFERENTIATION OF THE RUDIMENTS OF PEACH FLOWERS AFTER THE SEVERE WINTER OF 2020-2021
Authors: VASEHA V. V. , MATSVEEU V. A. , BARYSENKA M. M. , CHARNAVOKAYA K. A. 
Published: March 2023

The article sets the timeframe for the main phenological stages of peach, as well as the required amount of effective temperatures above +5 °C for their passing and growing season length based on the example of the variety of Belarusian selection Loiko.
The terms of the beginning of an organogenesis of flower rudiments after a severe winter and damage of generative buds,
skeletal branches are outlined. The peculiarities of the differentiation process during the growing season and the required amounts of effective temperatures for each stage of flower organogenesis in the central zone of Belarus are presented.
The data obtained show that in late November the process of differentiation in most generative buds stops at stage VII b
with a well-defined rudiment of the pistil and its clear differentiation into stigma and style. In the case of thawing during the winter, the process of organogenesis does not stop, and in February the development of flower buds in the generative buds
reaches stage VIII with the formation of the ovary and the growth of stamens with anthers of characteristic shape.