bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel peptide that disrupts the Lck-IP3R protein-protein interaction induces widespread cell death in leukemia and lymphoma
Authors: Harr Michael , Lavik Andrew , McColl Karen , Zhong Fei , Haberer Ben , Aldabbagh Khadijah , Yee Vivien , Distelhorst Clark W. 
Published: January 2023

Abstract

There is increasing evidence that the T-cell protein, Lck, is involved in the pathogenesis of chronic lymphocytic leukemia (CLL) as well as other leukemias and lymphomas. We previously discovered that Lck binds to domain 5 of inositol 1,4,5-trisphosphate receptors (IP3R) to regulate Ca2+ homeostasis. Using bioinformatics, we targeted a region within domain 5 of IP3R-1 predicted to facilitate protein-protein interactions (PPIs). We generated a synthetic 21 amino acid peptide, KKRMDLVLELKNNASKLLLAI, which constitutes a domain 5 sub-domain (D5SD) of IP3R-1 that specifically binds Lck via its SH2 domain. With the addition of an HIV-TAT sequence to enable cell permeability of D5SD peptide, we observed wide-spread, Ca2+-dependent, cell killing of hematological cancer cells when the Lck-IP3R PPI was disrupted by TAT-D5SD. All cell lines and primary cells were sensitive to D5SD peptide, but malignant T-cells were less sensitive compared with B-cell or myeloid malignancies. Mining of RNA-seq data showed that LCK was expressed in primary diffuse large B-cell lymphoma (DLBCL) as well as acute myeloid leukemia (AML). In fact, LCK shows a similar pattern of expression as many well-characterized AML oncogenes and is part of a protein interactome that includes FLT3-ITD, Notch-1, and Kit. Consistent with these findings, our data suggest that the Lck-IP3R PPI may protect malignant hematopoietic cells from death. Importantly, TAT-D5SD showed no cytotoxicity in three different non-hematopoietic cell lines; thus its ability to induce cell death appears specific to hematopoietic cells. Together, these data show that a peptide designed to disrupt the Lck-IP3R PPI has a wide range of pre-clinical activity in leukemia and lymphoma.
A new pyridine-dicarbohydrazide-based turn-off fluorescent and colorimetric chemosensor for selective recognition of Cu2+
Authors: Zamani Ali , Sarrafi Yaghoub , Tajbakhsh Mahmood 
Published: January 2023

Abstract
A novel indole-containing 2,6-pyridinedicarbohydrazide P3 was easily synthesized and well-characterized employing NMR, ESI+-MS, FT-IR, and elemental analyses. The synthesized compound was examined as an efficient turn-off fluorescent and colorimetric cation receptor. The P3 receptor exhibits a remarkable rapid color change from colorless to brown in the presence of the Cu2+ cation. P3 displayed selective fluorescence quenching and a UV-vis redshift only in the presence of Cu2+ ion. Job’s plot, NMR titration, and ESI+-MS data were used to determine the complex's 1:2 stoichiometry between P3 and Cu2+. Fluorescence titration was used to calculate the association constant (Ka) as (2.9–3.5) ×1011 M− 2 and LOD as \(\tilde\) 4.2 ×10−9 M. P3-based test strips were developed, which might be used as a simple and effective Cu2+ test kit. This design, which incorporates a functional group on the upper rim of the 2,6-pyridinedicarbohydrazide platform, is expected to provide another avenue for the development of chemosensors.
Bifunctional Metal-Loaded Micro-Mesoporous Zeolites for Waste Plastics Conversion to High Quality Liquid Product
Authors: Munir Dureem , Usman Muhammad R 
Published: January 2023

Abstract
A series of micro-mesoporous zeolitic catalysts synthesized using recrystallization of two different zeolites (HZSM-5 and beta) were impregnated with Pt and other notable metals. The resulting bifunctional catalysts were characterized and tested for the hydrocracking of a model municipal waste plastic mixture. Actual waste plastic mixture of the same composition was also employed for the comparison. The hydrocracking experiments were carried out in a Parr stirred batch reactor at 325, 350, and 375°C. The other reaction conditions were fixed at the initial cold H2 pressure of 20 bar, reaction time of 60 min, and plastic to catalyst ratio of 20:1 by wt. The inclusion of the Pt metal has shown to increase the hydrocracking activity of the micro-mesoporous supports. The Pt/micro-mesoporous ZSM-5 catalysts have shown the better activity while Pt/micro-mesoporous beta catalysts have shown better selectivity towards liquid. The presence of Pt metal has also produced a better quality liquid product with fewer unsaturated hydrocarbons and results in lower coke formation as determined by the TGA analysis of the spent catalysts.
Application of Roadmaps to Identify Gaps in the Implementation of Sales and Operations Planning in Large Industries
Authors: Chidem Denis , Vidor Gabriel , Medeiros Janine Fleith , Chiwiacowsky Leonardo Dagnino 
Published: January 2023

Abstract
This research aims to detail the maturity levels in the use of Sales Operations Planning and to propose the development of roadmaps to identify problems in the implementation of the model in companies. The Research Problem is related to how to apply roadmaps to identify gaps in the implementation of sales and operations planning in large size industries and the general objective is to apply roadmaps to identify gaps in the implementation of sales and operations planning in large size industries. In the bibliographical research several studies about SOP were found, which are presented in the theoretical framework of this work, as well as studies about roadmaps. The research method used is Design Science Research (DSR), which details the research structure and, after identifying the problem, proposes the use of a tool (instantiation artifact) to support the identified solutions. Data Collection is based on the instrument developed by Grimson and Pyke (2007), which measures the maturity level in the use of SOP in organizations and allows a deep detailing of the operations inherent to the processes. For the topic of roadmaps, the research of Phaal, Farrukh and Probert (2004) is used, which establishes important criteria that complement the objectives of this research. The expected results will be presented in the final analysis, which aims to describe the operations of each industry, classify them according to the SOP utilization levels, and identify the main gaps for the model's full utilization. After this analysis, roadmaps will be generated, highlighting the opportunities observed in the processes. Finally, proposals directed to the main desired managerial results, academic aspects, research limitations and future studies will be presented.
Effects of Bacillus Subtilis C-3102 addition to dry dog food on nutrient digestibility faecal characteristics, faecal microbiota and blood chemistry in healthy dogs
Authors: Kahraman Oguzhan , Gurbuz Emel , Inal Fatma , Arık Huzur Derya , Alatas Mustafa Selcuk , Inanc Zekeriya Safa , Ahmed Ibrar 
Published: January 2023

Abstract
This study evaluated the effects of Bacillus subtilis C-3102 supplementation on digestibility, faecal characteristics, some blood chemistry parameters and microbiota of dogs. Eighteen adult Golden retriever dogs were assigned to three treatments: control (no B. subtilis), 2g B. subtilis (5 × 108 CFU/g, BS1) and 4g B. subtilis (5 × 108 CFU/g, BS2) added groups. Dogs were fed 25 days of adaptation period followed by 5 days of faecal collection. Blood samples were taken from all dogs on the first and last day of the study. Fecal characteristics were evaluated on the last 3 days of the study by dry matter content, fecal score, fecal output, pH, ammonia, short (SCFA) and branched chain fatty acids. Improved dry matter, fibre, organic matter and protein digestibility coefficents were determined in BS1 and BS2 (P < 0.05). Lower pH, higher dry matter, acetate, propionate and isobutyrate levels in feaces were determined in BS1 and BS2 (P < 0.05). Lower ammonia and firmer stools were observed in BS2 (P < 0.001). Counts of CFU of faecal Enterococci, Lactobacilli were improved BS1 and BS2 (P < 0.05). Serum cholesterol and triglyceride levels were not affected (P > 0.05). Higher values of WBCs, RBCs and granulocyte were recorded in B.subtilis groups (P < 0.05). In conclusion, supplementation of B. subtilis in dog food improved faecal quality, enhanced digestibility of diet and contributed to the health by supporting immune functions of dogs, reducing gut ammonia, increasing SCFA and number of Lactobacillus and Enterecocci.
Covid-19 and Dynamic Changes in Learning Environment: A Perceptional Study
Authors: Amin Venkatesh S , N Abhishek , Kulal Abhinandan , Srini Sagar 
Published: January 2023

AbstractDe-addiction of mobile in students has become a challenge for both urban and rural parents. Students were forced to use mobile handsets and in-spite of the hybrid learning mode adopted and adapted by schools and colleges; due to Covid and its challenges. Covid has made things clearer to learn by distance and maintain the social distance. India is full of villages and most parents are unaware of what students are watching on their mobile. Children and students camouflage their parents by projecting as attending an online class. This has become a challenge to de-addict and bring them back to normal learning. The present study intends to analyses the dynamic changes in the learning environment during pre and post Covid learning environment. The outcome of the study indicated that the that there is significant difference in the learning environment and it also revealed that after covid the learning environment became unfavourable.
WITHDRAWN: Mathematical Model of Radicalization And Terrorism Dynamics in the Central Sahel
Authors: ZOROM Malicki , LEYE Babacar , COLY Serigne M'back , DIOP Mamadou , GANA Abdou LAWANE , BOLOGO/TRAORE Maïmouna , NIANG Dial 
Published: January 2023

Abstract
The increase in violence has created an unprecedented crisis in the Sahel, particularly the Central Sahel, with massive displacement of populations already vulnerable to climatic hazards. This paper aims to propose a mathematical model of the ordinary differential equation system that will reflect the dynamics of terrorism and internal displacement. Sobol's sensitivity analysis of the model's parameters will allow us to make proposals for reducing terrorism. Military actions alone do not contribute effectively for fight against terrorism because they only contribute less than 20%. Radicalization prevention and de-radicalization strategies must be adopted jointly to effectively reduce the spread of terrorism because they contribute more than 80% for fight against terrorism.
Investigation on factors causing construction delay and their effects on the development of Oman’s construction industry
Authors: Javed Shakila , Hussain Mohammed Ihtesham , Al Aamri Ahmed Majid , Akhtar Javed 
Published: January 2023

Construction delay in projects is a common manifestation in the construction industry. Delay in construction will lead to a bad relationship between the parties involved and will also lead to an increase in the allocated completion time. Delay in the ongoing project might result in the loss of the money, time and other facilities by the client and cause a lot of financial damage to the contractor due to its investment in the purchase of equipment, construction materials and the hire of skilled workers. Delay in construction is a common problem that occurs mostly due to the unforeseen problems during the design & construction stages which often lead to delays in the completion of the project. Oman’s construction industry is one of the most important industries for the country’s economic development and growth. In this study, analysis of some available literature was conducted, and a questionnaire survey was floated among contractors, consultants, clients, project managers, and engineers involved in construction projects. All the collected responses were evaluated by using SPSS. The results of the study identified a total of 60 causes of delay out of which three factors have a “High” significance level for construction delays. These factors of “High” significance were associated with “Client related issues only” in which the initial design was altered by the client, delaying in deciding by the client and, scope change by the client. Majority of the delay (84 %) was observed to be lying in the range of 1‑2 years. This study also recognized the effect and minimization of regular delay and delay resulted due to Covid-19. Minimizing construction delay criteria can be managed by having a proper control system in the project time and funds
Neutronics analysis of UN-PuN fuel for 300MW pressurized water reactor using SRAC-COREBN code
Authors: Syarifah Ratna Dewi , Sari Arindi Kumala , Arkundato Artoto , Irwanto Dwi , Su’ud Zaki 
Published: January 2023

Nuclear Power Plants (NPP) is one of alternative energy that can be used to replace fossil energy. NPP is a clean energy that doesn't emit CO2 as a residue from the power plant. Pressurized Water Reactor (PWR) is the most widely used commercial reactor to date. This reactor usually uses UO2 as fuel with enrich U-235 and produce plutonium as a waste nuclear. In this study, the fuel uses natural uranium and the addition of plutonium from the spent fuel of PWR, calling it Uranium-Plutonium Nitride (UN-PuN) fuel. Plutonium from spent fuel PWR (U-fueled) consists of Pu-238, Pu-239, Pu-240, Pu-241 and Pu-242, which Pu-239 and Pu-241 are fissile material. The aim of using plutonium is to reduce the amount of nuclear waste and prevent the use of plutonium as a nuclear weapon. The addition of neptunium and protactinium is also carried out in the fuel. Neptunium is one of the minor actinide materials which have high toxicity, so add Np-237 it is very useful to reduce the amount of neptunium in the world. And also, the addition of Np-237 and Pa-231 aims to decrease the keff value both in the Beginning of Life (BOL) and End of Life (EOL) in the reactor. This research calculates the neutronic calculations for PWR use SRAC2006 with COREBN Code and Japanese Evaluated Nuclear Data Library 4.0 (JENDL-4.0) for the nuclear data library. The COREBN code is a calculation method based on interpolation of macroscopic cross-section and finite-difference diffusion theory. The optimum design reached the maximum k-eff value 1.017077 and the maximum power density was 58.47 W/cc. The results obtained are the excess reactivity value of 1.68 % smaller than previous study which produces an excess reactivity value of 11.94 %. So this design has the potential to be applied in the PWR design
Expert opinion-based multi objective optimization: an application in plasma coating technology
Authors: Duong Vu , Van Cuong Nguyen 
Published: January 2023

Multi-objective optimization is a very important activity which is applied in many different fields. When solving this problem, it is important to determine weights for criteria. If the weight of criteria is determined according to dry mathematical formulas, the opinion of researchers will be ruined. On the contrary, if the weight of criteria is determined according to the subjective opinion of researchers, it is also easy to make mistakes. This study applies a method of determining the weight of criteria based on experts' opinions and conditions must be also strictly satisfied, thereby both of the above limitations have been remedied. Such method is known as FUCOM (FUll COonsistency Method). An application example was carried out for multi-objective optimization in the plasma coating process. Plasma coating is a modern coating technology. This method is increasingly used in many different fields. However, determining the value of technological parameters to ensure the quality of high-quality products is a very complicated job. In order to ensure many requirements of the product, it is necessary to determine the optimal value of the technological parameters. Four criteria to evaluate a coating process include the adhesion strength of the coating, the shear strength of the coating, the tensile strength of the coating, and the porosity of the coating. The task of multi-objective optimization in this study is to determine the values of three input parameters (including: spray current intensity, powder feed flow, and spray distance) to ensure that the desired values of the four criteria are simultaneously achieved. After the weight of criteria is determined by the FUCOM method, the multi-objective optimization problem has been solved. Experiments to verify the optimal results were also conducted, thereby demonstrating the correctness of the methodology. The optimal values of the technology parameters (spray current intensity, powder feed flow, and spray distance) have been determined to be 568.69 A, 31.87 g/min, and 170.19 mm, respectively
Nanoformulations of Anti-cancer Agents: Present Status & Future Directions
Authors: Chaudhary Anurag , Garg Urvashi , Kumar Shobhit 
Published: January 2023

Abstract:Nanoformulations are a novel method of administration of the drug, approved by the USFDA. These formulations are able to deliver the drug molecules to the target site more effective-ly and efficiently. So, this technology has found a vital role in cancer therapy. The nanoformula-tions can be of many types: Liposomes, Micelles, Nano-emulsions, Dendrimers, etc. Many studies have been done on nanoformulations and it is revealed that a number of natural products like cur-cumin, thymoquinone and papaverine, which contain anti-cancer activity, are more effective in nanoformulation form. This review discusses the nanoformulations, their applications, uses and ad-vantages in cancer therapy along with the anti-cancer drugs that are administered as nanoformula-tions.
Pengaruh Pembagian Waktu Kerja Terhadap Keseimbangan Kehidupan Kerja, Kepuasan Kerja Dan Retensi Karyawan
Authors: Isni Sefta Nandiatama Fahrizal , Amalia Lia , Anindita Rina 
Published: January 2023

Penelitian terhadap karyawan di industri penerbangan ini memiliki tujuann untuk mengetahui bagaimana pengaruh dari pembagian waktu kerja terhadap keseimbangan kehidupan kerja, kepuasan kerja dan retensi karyawan. Penelitian ini berangkat dari penelitian sebelumnya dengan perbedaan latar belakang industri dan lokasi. Perbedaannya dengan penelitian ini adalah dengan menambahkan variabel retensi karyawan. Jumlah responden dalam penelitian ini adalah sebanyak 167 orang yang bekerja dengan sistem pembagian waktu kerja. Pengumpulan data dilakukan dalam rentang waktu Juli hingga Agustus dengan cara survey secara daring menggunakan Google Form serta responden dipilih dengan metode purposive sampling di Airnav Indonesia. Hasil analisis menggunakan analisis faktor dan pemodelan persamaan structural (Structural Equalion Modelling) dengan menggunakan LISREL. Hasil dari penelitian ini adalah pembagian waktu kerja memiliki pengaruh positif terhadap keseimbangan kerja dan retensi karyawan. Selain itu, keseimbangan kehidupan kerja juga memiliki hubungan positif terhadap kepuasan kerja dan retensi karyawan. Temuan pada penelitian ini adalah pembagian waktu kerja tidak memiliki hubungan dengan kepuasan kerja, namun dapat menambahkan keseimbangan kehidupan kerja sebagai mediasi antara pembagian waktu kerja dan kepuasan kerja. Keterbatasan penelitian ini adalah penelitian hanya dilakukan pada satu perusahaan dan perlunya melakukan pengukuran lebih mendalam terkait kepuasan kerja serta penelitian ini dilakukan pasca pandemi.Kata Kunci: Pembagian Waktu Kerja, Keseimbangan Kehidupan Kerja, Kepuasan Kerja, Retensi Karywan, Industri Penerbangan
Attitudes of Physicians and Individuals Toward Digital Mental Health Tools: Protocol for a Web-Based Survey Research Project
Authors: Nogueira-Leite Diogo , Cruz-Correia Ricardo 
Published: January 2023

Background
Digital transformation is impacting health care delivery. Great market dynamism is bringing opportunities and concerns alike into public discussion. Digital health apps are a vibrant segment where regulation is emerging, with Germany paving the way with its DiGA (Digitale Gesundheitsanwendungen, in German, meaning digital health apps) program. Simultaneously, mental ill-health constitutes a global health concern, and prevalence is expected to worsen due to the COVID-19 pandemic and its containment measures. Portugal and its National Health System may be a useful testbed for digital health interventions.

Objective
The paper outlines the protocol for a research project on the attitudes of physicians and potential users toward digital mental health apps to improve access to care, patient outcomes, and reduce the burden of disease of mental ill-health.

Methods
Web surveys will be conducted to acquire data from the main stakeholders (physicians and the academic community). Data analysis will replicate the statistical analysis performed in the studies from Dahlhausen and Borghouts to derive conclusions regarding the relative acceptance and likelihood of successful implementation of digital mental health apps in Portugal.

Results
The findings of the proposed studies will elicit important information on how physicians and individuals perceive digital mental health app interventions to improve access to care, patient outcomes, and reduce the burden of disease of mental ill-health. Data collection ran between September 26 and November 6, 2022, for the first study and September 20 and October 20, 2022, for the second study. We obtained 160 responses to the first study’s survey and 539 answers to the second study’s survey. Data analysis is concluded, and both studies’ results are expected to be published in 2023.

Conclusions
The results of the studies projected in this research protocol will have implications for researchers and academia, industry, and policy makers concerning the adoption and implementation of digital health mental apps and associated interventions.

International Registered Report Identifier (IRRID)
DERR1-10.2196/41040
ITRF2020: The ILRS Contribution and Operational Implementation
Authors: Pavlis Erricos , Luceri V , Basoni A , Sarrocco D , Kuzmicz-Cieslak M , Evans K , Bianco G 
Published: January 2023

The ILRS contribution to ITRF2020 is a time series of weekly/bi-weekly
SINEXs with station position estimates and EOP, from 7-day arcs (1993.0
– 2021.0) and 15-day arcs over 1983.0- 1993.0. Each solution was
obtained as the combination of loosely constrained individual solutions
from the seven ILRS Analysis Centers: ASI, BKG, DGFI, ESA, GFZ, JCET and
NSGF. Everyone followed strict standards agreed within the ILRS Analysis
Standing Committee (ASC) and used SLR data from LAGEOS, LAGEOS-2,
Etalon-1 and Etalon-2, (LAGEOS-only from 1983 to 1992). The ILRS ASC
devised an innovative approach in handling systematic errors in the
network, never before utilized. After a 5-year pilot-project documented
in Luceri et al., (2019). The Station Systematic Error Monitoring PP
(SSEM), delivered a series of long-term mean bias estimates for each
station, the time intervals of applicability and their statistics. They
were derived from freely adjusted station position and EOP solutions for
the period 1993.0 to 2020.5, using the latest satellite CoG model. The
simultaneous estimation of the station heights and measurement biases
resulted in a self-consistent set of weekly bias estimates for each
site. Breaks and “jumps” were used to decne the periods of
applicability and to calculate the mean bias and its standard deviation.
The mean biases were pre-applied in the re- analysis, limiting the
remaining jitter of the bias to negligible level. This approach
strengthened the estimation process without a compromise of the cnal
results’ accuracy. As a result, the ILRS contribution to ITRF2020
minimized the scale difference between SLR and VLBI to below 2 mm
(ITRF2014 ~9 mm). We present an overview of the
procedures, models, the improvement over previous ILRS products,
focusing especially on the Core ILRS sites, and an overview of how the
new model has been implemented in support of the ILRS ogcial products.