bluuebunny/crossref_metadata_2025_split huggingface dataset:
Who am I? The identity crisis of mental health professionals living with mental illness
Authors: Fisher Jane 
Published: April 2023

Accessible SummaryWhat is known on the subject?

Large numbers of mental health professionals live with their own mental health challenges.

Despite working in mental health care, they can experience stigma in the workplace.

Mental health professionals with lived experience of mental illness can find it a challenge to integrate their identities as both mental health professional and mental health service user.

There are currently limited options available to them.

What the paper adds to existing knowledge?

This is a personal reflection from a mental health nurse and lecturer, who lives with a severe and enduring mental illness.

It offers a lived experience account of the identity struggles of a mental health professional living with a mental illness.

This article attempts to redefine the identity of professionals with personal lived experience in a more positive manner. They can be valued and celebrated for their unique perspective on mental illness and mental health care.

What are the implications for practice?

There remains a stigma attached to people living with mental health conditions. This article challenges some of this stigma.

It will empower and encourage other health professionals with lived experience to embrace all aspects of their identity with authenticity and courage.

AbstractThere are growing numbers of mental health professionals with their own lived experience of mental illness. This is both in part due to increased visibility and openness, and students embarking on professional courses motivated by their own personal mental health history. The somewhat limited research in this area highlights the difficulty practitioners have in navigating this distinct identity. There are limited options, including a wounded healer, an impaired professional and professional survivor. All have their limitations. We need to revise the conceptualisation of mental health professionals with personal lived experience of mental illness. Our identity needs to be celebrated and valued, as are the roles of peer support worker and expert by experience. Through personal reflection, I describe my own challenges in negotiating my identity as a mental health nurse, lecturer, and service user. My solution is to embrace authenticity and have the courage to stand in vulnerability and strength, embracing all aspects of myself. I call for others to do the same.
Risk factors for more rapid progression of severe liver fibrosis in children with cystic fibrosis‐related liver disease: A multi‐center study validated by liver biopsy
Authors: Sakhuja Shruti , Staples Heather M. , Minard Charles G. , Ramm Louise E. , Lewindon Peter J. , Ramm Grant A. , Leung Daniel H. 
Published: April 2023

AbstractBackground and AimsEarly identification of risk factors for the development of severe fibrosis in children with cystic fibrosis‐related liver disease (CFLD) is crucial as promising therapies emerge.MethodsThis multi‐center cohort study of children with a priori defined CFLD from 1999 to 2016, was designed to evaluate the clinical utility of CF‐specific characteristics and liver biomarkers assessed years prior to liver biopsy‐proven CFLD to predict risk of developing severe fibrosis (F3‐4) over time. Fibrosis was staged by Metavir classification.ResultsThe overall study cohort of 42 patients (F0‐2 (n = 22) and F3‐4 (n = 20)) was 57% male (n = 24) with median age of 7.6 years at baseline visit versus 10.3 years at biopsy. Median FEV1% predicted was lower in F3‐4 participants at baseline versus F0‐2 (59% vs. 85%; p = .002), while baseline FIB‐4, APRI and GGT were higher in F3‐4. Median splits for FIB‐4 (≥.13), APRI (≥.36), GPR (≥.09), GGT (≥25.5), and FEV1% (<64%) were associated with more rapid progression to F3‐4 (p < .01 for all). Using a combination of change/year in FIB‐4, APRI, and GPR to predict F3‐4, the AUROC was .81 (95% CI, .66, .96; p < .0001). For up to 5.8 years prior, thresholds for GPR were met 6.5‐fold more rapidly, and those for APRI and FIB‐4 were met 2.5‐fold more rapidly, in those who progressed to F3‐4 than those that did not.ConclusionsThis study suggests mild–moderate pulmonary dysfunction and higher liver biomarker indices at baseline may be associated with faster progression of CFLD.
Cryptic biodiversity inhabiting coral reef sponges
Authors: George Anita M. , Abdo Dave , Wahab Muhammad Azmi Abdul , Ekins Merrick , Hooper John N. A. , Whalan Steve 
Published: April 2023

AbstractSponges host a wide range of cryptic biodiversity both internally and externally. This study quantified the biodiversity inhabiting, or associated with, three morphologically distinct coral reef sponges. Coelocarteria singaporensis, Coscinoderma mathewsi and Ircinia microconulosa were collected from fringing reefs at Orpheus Island, central Great Barrier Reef, across monsoonal seasons (wet and dry) and diurnal periods (morning, afternoon and night for C. singaporensis) to quantify Sponge Associated Biota (SAB). A total of 8489 SAB was sorted from 77 sponges. Twenty‐six taxa, across 3 kingdoms and 12 phyla were recorded. Sponge‐associated biota was dominated by Mollusca in all three sponge hosts (range ~ 46%–50%) but taxa were found from a number of other phyla including, Arthropoda, Annelida, Echinodermata, Cnidaria, Foraminifera and Nemertea. There was no effect of season on abundances of SAB within the three species of sponge, but there was a significant effect associated with sponge host species, driven by a higher number of SAB in C. singaporensis and I. microconulosa. The diurnal patterns of SAB within C. singaporensis showed consistent abundances of mobile invertebrate groups with molluscs, echinoderms and arthropods dominating these samples. This study also highlights the ecological role and contribution of SAB in the reef ecosystems.
The grain size distribution of matrix in primitive chondrites
Authors: Vaccaro E. , Wozniakiewicz P. , Franchi I. A. , Starkey N. , Russell S. S. 
Published: April 2023

AbstractThe matrix of primitive chondrites is composed of submicron crystals embedded in amorphous silicates. These grains are thought to be the remains of relatively unprocessed dust from the inner regions of the protoplanetary disk. The matrix of primitive meteorites is often compared to chondritic porous interplanetary dust particles (CP‐IDPs) which are believed to be of cometary origin, having accreted in the outermost regions of the solar nebula. Crystalline grains in CP‐IDPs show evidence of a size–density relationship between the silicates and sulfides suggesting that these components experienced sorting prior to accretion. Here, we investigate whether such evidence of sorting is also present in the matrix constituents of primitive chondrites. We report findings from our study of grain size distributions of discrete silicate and opaque (sulfide and metal) grains within the matrix of the primitive meteorites Acfer 094 (C2‐ung.), ALHA77307 (CO3), MIL 07687 (C3‐ung.), and QUE 99177 (CR2). Mean radii of matrix silicate grains range from 103 nm in QUE 99177 to 2018 nm in MIL 07687. The opaque grains show a wider variation, with average radii ranging from 15 nm in QUE 99177 to 219 nm in MIL07687. Our results indicate that, in contrast to CP‐IDPs, the size distribution of matrix components of these primitive meteorites cannot be explained by aerodynamic sorting that took place prior to accretion. We conclude that any evidence of sorting is likely to have been lost due to a greater variety and degree of processing experienced on these primitive chondrites than on cometary parent bodies.
Optimizing nutrition in pediatric intestinal pseudo‐obstruction syndrome
Authors: Pescarin Matilde , Day Hannah , Thapar Nikhil , Jackman Lucy , Saliakellis Efstratios , Lindley Keith J. , Nikaki Kornilia , Hill Susan , Kӧglmeier Jutta , Rybak Anna , Borrelli Osvaldo 
Published: April 2023

AbstractBackgroundPediatric intestinal pseudo‐obstruction (PIPO) encompasses a variety of rare, heterogeneous, and disabling disorders that severely affect gastrointestinal motility and are associated with high morbidity and mortality. PIPO management is complex and focuses on maintaining an optimal nutritional status, improving gut function, relieving symptoms, and treating complications. Nutritional issues prevail, and PIPO patients often experience severe undernutrition and faltering growth. Thus, nutritional management plays a pivotal role for achieving the most favorable clinical outcomes. The calorie and nutrient intake of each patient needs to be tailored to age, extent and severity of gut involvement and nutritional needs to support an optimal nutritional status. After defining the extent and severity of gut dysmotility, an experienced team should perform a careful nutritional assessment. An oral diet should always be encouraged and might include bite and dissolve solids, liquid diet or simple oral stimulation. If oral caloric intake is inadequate, liquid gastric feeds should provide the subsequent step. In the presence of severe gastric dysmotility, continuous post‐pyloric feeding represents a viable option. In the most severe cases, parenteral nutrition (PN) is required to meet appropriate nutritional requirements.PurposePediatric data on this topic are scarce and mainly extrapolated from adult studies. In this review, we discuss current evidence and knowledge regarding nutritional options, implications of the use of different feed types, including a blended diet, and the use of PN. Moreover, based on our experience and the evidence from the literature, we propose a flow chart to guide the nutritional management of PIPO patients.
Children with functional gastrointestinal disorders with and withoutco‐existingnausea: A comparison of clinical and psychological characteristics
Authors: de Bruijn Clara M. A. , Geijtenbeek Anne , Browne Pamela D. , Benninga Marc A. , Vlieger Arine M. 
Published: April 2023

AbstractBackgroundNausea co‐existing with functional gastrointestinal disorders (FGIDs) has been suggested to negatively impact physical and psychological factors in children. This study aims to compare clinical and psychological characteristics of a large cohort of pediatric patients with an FGID with and without nausea.MethodsPatients of two previous randomized controlled trials were included, the first assessing the effect of hypnotherapy (HT) in 260 children fulfilling Rome criteria of irritable bowel syndrome (IBS) or functional abdominal pain (FAP), the second examining the effect of HT in 100 children with nausea in children with either functional nausea (FN) or functional dyspepsia (FD). At inclusion, demographics, clinical features, including the presence of nausea, depression and anxiety, somatization, and health‐related quality of life (QoL) were assessed in patients.Key ResultsIn total, 355 patients with IBS (n = 131), FAP (n = 127), FN (n = 62), and FD (n = 35) were included, of which 255 (72%) patients experienced nausea versus 100 (28%) without nausea. Age at onset of symptoms was higher in children experiencing nausea (12.0y vs. 9.0y,p = 0.000). Significantly higher somatization, anxiety and depression scores, and lower health‐related QoL were reported for children with nausea. There were no significant differences between children with only nausea and children with nausea and abdominal pain.Conclusions and InferencesChildren with nausea, either with or without abdominal pain, report higher somatization scores, increased anxiety and depression, and lower overall QoL, compared to children with pain‐related FGIDs without accompanying nausea. Addressing the presence of nausea in children with FGIDs seems essential to customize their treatment and improve overall quality of life.
Association of oral behaviours and psychological factors with selected genotypes in pain‐related TMD
Authors: Zlendić Marko , Vrbanović Ema , Tomljanović Marko , Gall Trošelj Koraljka , Đerfi Kristina Vuković , Alajbeg Iva Z. 
Published: April 2023

AbstractObjectivesTo investigate frequency of single nucleotide polymorphisms (SNPs) in pain‐related temporomandibular disorders (TMDp) and to determine whether specific SNPs, psychological, psychosomatic and behavioural characteristics are predictive for pain existence and intensity (low pain intensity (LPI)/high pain intensity (HPI)).MethodsGenomic DNA was extracted from buccal mucosa swabs (85 TMDp;85 controls) for evaluating frequency of selected SNPs: catechol‐O‐methyltransferase (rs4680, rs4818), opiorphin (rs1387964), alpha subunit of voltage‐gated sodium channel Nav1.1 (rs6432860) and voltage‐gated sodium channel Nav1.9 (rs33985936). Participants completed questionnaires on somatosensory amplification, anxiety and depression symptoms and oral behaviours (OB).ResultsSleep‐related OB frequency was higher in TMDp patients compared to controls (p = 0.008). Compared to LPI, HPI patients had higher depression (p = 0.020) and anxiety scores (p = 0.017). TMDp group showed higher frequency of CC genotype (rs1387964) than controls (12.9% vs. 3.5%, p = 0.025). Following adjustments for age, sex and sleep‐related OB, the significance of the recessive model (CC vs. TC + TT) between TMDp patients and controls was retained (OR = 5.783; 95%CI: 1.454–23.004). Frequency of GG genotype (rs4680 and rs4818) was higher in HPI compared to LPI patients (40% vs. 11.4%, p = 0.006; 24% vs. 3%; p = 0.012, respectively). The difference remained significant after adjusting for age, sex, depression, anxiety and sleep‐related OB (rs4680: OR = 3.621; 95%CI: 1.580–8.297; rs4818: OR = 4.919, 95%CI: 1.641–14.746).ConclusionThis study has demonstrated that rs1387964 CC genotype was associated with TMDp while rs4680 GG and rs4818 GG genotypes contributed to HPI.
Lasanius, an exceptionally preserved Silurian jawless fish from Scotland
Authors: Reeves Jane C. , Wogelius Roy A. , Keating Joseph N. , Sansom Robert S. 
Published: April 2023

AbstractThe fossil record of non‐biomineralizing, soft‐bodied taxa is our only direct evidence of the early history of vertebrates. A robust reconstruction of the affinities of these taxa is critical to unlocking vertebrate origins and understanding the evolution of skeletal tissues, but these taxa invariably have unstable and poorly supported phylogenetic positions. At the cusp between mineralized bony vertebrates and entirely soft‐bodied vertebrates is the enigmaticLasanius, a purported anaspid from the Silurian of Scotland. Interpretations of its affinity and significance are conflicted, principally because of its poorly understood anatomy due to taphonomic distortion and loss of soft‐tissues. Here we use an array of modern techniques to reassess the anatomy ofLasaniusvia a comprehensive study of 229 complete and partial specimens. A new reconstruction clarifies the identity and position of preserved features, including paired sensory organs, a notochord, and digestive tract, supporting the vertebrate affinities of this genus. SEM‐EDS trace element mapping suggests a bone‐like composition of mineralized parts, but finds no evidence for mineralized dermal armour. Phylogenetic analysis recoversLasaniusas an early stem‐cyclostome, and subsequent analysis supports the rejection of alternative placements (such as stem‐gnathostome). We highlight that while distinguishing between the early cyclostome and gnathostome condition is problematic, increasing confidence in the anatomy of key taxa, such asLasanius, is vital for increased stability throughout the early vertebrate tree.
Contrasting patterns of disparity suggest differing constraints on the evolution of trilobite cephalic structures during the Cambrian ‘explosion’
Authors: Holmes James D. 
Published: April 2023

AbstractTrilobites are an abundant group of Palaeozoic marine euarthropods that appear abruptly in the fossil recordc. 521 million years ago. Quantifying the development of morphological variation (or ‘disparity’) through time in fossil groups like trilobites is critical in understanding evolutionary radiations such as the Cambrian ‘explosion’. Here, I use geometric morphometrics to quantify ‘cumulative disparity’ in functionally‐important structures within the trilobite cephalon across their initial radiation during Cambrian Series 2. Overall cephalic disparity increased rapidly and attained a maximum within several million years. This pattern is dominated by the cephalic outline (in particular the genal spines), reflecting rapid, convergent expansion to the extremes of morphospace in a few early families. In contrast, removing the outline and focusing on structures such as the glabella and eye ridges (associated with feeding and vision, respectively) showed a more gradual increase in disparity, closer in line with taxonomic diversity and supporting the hypothesis of a relatively accurate trilobite fossil record. These contrasting patterns suggest that disparity in different structures was constrained in different ways, with extrinsic (ecological) factors probably having the major impact on overall disparity. It also implies that patterns of disparity in isolated substructures cannot necessarily be taken individually as representative of overall morphologies.
Tunable control of insect pheromone biosynthesis in Nicotiana benthamiana
Authors: Kallam Kalyani , Moreno‐Giménez Elena , Mateos‐Fernández Ruben , Tansley Connor , Gianoglio Silvia , Orzaez Diego , Patron Nicola 
Published: April 2023

SummaryPrevious work has demonstrated that plants can be used as production platforms for molecules used in health, medicine, and agriculture. Production has been exemplified in both stable transgenic plants and using transient expression strategies. In particular, species of Nicotiana have been engineered to produce a range of useful molecules, including insect sex pheromones, which are valued for species‐specific control of agricultural pests. To date, most studies have relied on strong constitutive expression of all pathway genes. However, work in microbes has demonstrated that yields can be improved by controlling and balancing gene expression. Synthetic regulatory elements that provide control over the timing and levels of gene expression are therefore useful for maximizing yields from heterologous biosynthetic pathways. In this study, we demonstrate the use of pathway engineering and synthetic genetic elements for controlling the timing and levels of production of Lepidopteran sex pheromones in Nicotiana benthamiana. We demonstrate that copper can be used as a low‐cost molecule for tightly regulated inducible expression. Further, we show how construct architecture influences relative gene expression and, consequently, product yields in multigene constructs. We compare a number of synthetic orthogonal regulatory elements and demonstrate maximal yields from constructs in which expression is mediated by dCas9‐based synthetic transcriptional activators. The approaches demonstrated here provide new insights into the heterologous reconstruction of metabolic pathways in plants.
Increased GS‐II lectin binding and SATB2 downregulation are biological features for sessile serrated lesions and microvesicular hyperplastic polyps
Authors: Matoba Hisanori , Iwaya Mai , Sato Yoshiko , Kobayashi Noriyasu , Takemura Haruka , Kouno Yusuke , Karasawa Ayumi , Nakayama Jun 
Published: April 2023

AbstractSessile serrated lesions (SSLs) and microvesicular hyperplastic polyps (MVHPs) are colorectal lesions displaying gastric differentiation. Griffonia simplicifolia‐II (GS‐II) is a lectin specific to terminal α/βGlcNAc residues. Here, we assessed GS‐II binding and performed immunostaining for HIK1083 (specific to terminal αGlcNAc residues), MUC5AC, MUC6, and special AT‐rich sequence binding protein 2 (SATB2) in SSLs, MVHPs, and tubular adenomas (TAs). We observed MUC5AC positivity in 28 of 30 SSLs, but in only three of 23 TAs. Moreover, 24 of 30 SSLs were MUC6‐positive, while none of the 23 TAs were MUC6‐positive. None of the 30 SSLs or 23 TAs showed HIK1083 positivity. All 30 SSLs and 26 MVHPs were GS‐II‐positive, while only seven of 23 were in TAs. GS‐II staining was mainly distributed in the Golgi region, but SSLs and MVHPs showed goblet cell distribution, in 20 of 30 and 19 of 26 cases, respectively. All SSLs, MVHPs, and TAs were SATB2‐positive, but 21 of 30 SSLs and 12 of 26 MVHPs showed decreased staining intensity relative to adjacent mucosa, a decrease seen in only two of 23 in TAs. These results indicate overall that increased terminal βGlcNAc and decreased SATB2 expression are characteristics of SSLs and MVHPs.
Source attribution of campylobacteriosis in Australia, 2017–2019
Authors: McLure Angus , Smith James J. , Firestone Simon Matthew , Kirk Martyn D. , French Nigel , Fearnley Emily , Wallace Rhiannon , Valcanis Mary , Bulach Dieter , Moffatt Cameron R. M. , Selvey Linda A. , Jennison Amy , Cribb Danielle M. , Glass Kathryn 
Published: April 2023

AbstractCampylobacter jejuni and Campylobacter coli infections are the leading cause of foodborne gastroenteritis in high‐income countries. Campylobacter colonizes a variety of warm‐blooded hosts that are reservoirs for human campylobacteriosis. The proportions of Australian cases attributable to different animal reservoirs are unknown but can be estimated by comparing the frequency of different sequence types in cases and reservoirs. Campylobacter isolates were obtained from notified human cases and raw meat and offal from the major livestock in Australia between 2017 and 2019. Isolates were typed using multi‐locus sequence genotyping. We used Bayesian source attribution models including the asymmetric island model, the modified Hald model, and their generalizations. Some models included an “unsampled” source to estimate the proportion of cases attributable to wild, feral, or domestic animal reservoirs not sampled in our study. Model fits were compared using the Watanabe–Akaike information criterion. We included 612 food and 710 human case isolates. The best fitting models attributed >80% of Campylobacter cases to chickens, with a greater proportion of C. coli (>84%) than C. jejuni (>77%). The best fitting model that included an unsampled source attributed 14% (95% credible interval [CrI]: 0.3%–32%) to the unsampled source and only 2% to ruminants (95% CrI: 0.3%–12%) and 2% to pigs (95% CrI: 0.2%–11%) The best fitting model that did not include an unsampled source attributed 12% to ruminants (95% CrI: 1.3%–33%) and 6% to pigs (95% CrI: 1.1%–19%). Chickens were the leading source of human Campylobacter infections in Australia in 2017–2019 and should remain the focus of interventions to reduce burden.
ECOLOGICAL SAINTS: ADOPTING A GREEN GAZE OF THE LIFE AND WRITINGS OF SAINT MARGUERITE BOURGEOYS
Authors: Osgood Libby 
Published: April 2023

AbstractDuring this time of ecological crisis, spiritual guides are needed to provide inspiration and impel action. In the Roman Catholic tradition, saints act as role models and are associated with particular causes, locations, or professions. Who, then, are the ecological saints, whose witness can inspire hope and action in support of the environment? This article explores that question in two ways. First the writings and accounts of saints who are traditionally connected to the environment are examined to produce six indicators of the beliefs, characteristics, and actions of ecological saints. Second, a green gaze is applied to Saint Marguerite Bourgeoys, a seventeenth‐century educator who lived in what would become Montreal, Canada, by comparing her writings and accounts of her life to the six indicators of an ecological saint. Identifying more ecological saints can promote environmental responsibility, and the six indicators of an ecological saint can be the lens through which beloved saints are re‐examined.