bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aspartame and Phenylketonuria: an analysis of the daily phenylalanine intake of aspartame-containing drugs marketed in France
Authors: Maler Victor , Goetz Violette , Tardieu Marine , Khalil Abderrahmane El , Alili Jean Meidi , Meunier Philippe , Maillot François , Labarthe François 
Published: June 2023

Abstract
Background
Phenylketonuria (PKU) is a rare genetic metabolic disorder in which especially high phenylalanine (Phe) concentrations cause brain dysfunction. If untreated, this brain dysfunction results in severe microcephaly, intellectual disability, and behavioral problems. Dietary restriction of Phe is the mainstay of PKU treatment, with long-term successful outcomes. Aspartame, an artificial sweetener sometimes added into medications, is metabolized in the gut into Phe. Then, patients suffering from PKU on a Phe-restricted diet should avoid consumption of aspartame. The aim of our study was to evaluate the number of drugs containing aspartame and/or Phe as an excipient, and to quantify their corresponding Phe intake.

Methods
The list of drugs marketed in France containing aspartame and/or Phe was established using a national medication database called “Theriaque”. For each drug, the corresponding daily Phe intake was calculated according to age and weight and was distributed into 3 categories: high (> 40 mg/d), medium (10 to 40 mg/d) and low (< 10 mg/d) Phe intake.

Results
The number of drugs containing Phe or its precursor aspartame remained very limited (n = 401). Among the aspartame containing drugs, Phe intakes were significant (medium or high) for only half of them whereas there were negligible for the others. Furthermore, these medications with a significant Phe intake were limited to few pharmaceutical classes (mainly antiinfectives agents, analgesics, and drugs for nervous system), and within these classes the drugs were limited to a small number of molecules, including principally amoxicillin, amoxicillin + clavulanic acid and paracetamol/ acetaminophen.

Discussion
In situations requiring the use of these molecules, we propose as an alternative, the use of an aspartame-free form of these molecules or a form with a low Phe intake. If it is not possible, we propose as second-line the use of another antibiotics or analgesics. Finally, we have to remember the benefits-risk balance to use medications containing significant Phe intake in PKU patients. Indeed, it may be better to use a Phe containing medication in the absence of an aspartame-free form of this drug rather than to leave a person with PKU without treatment.
A nationwide questionnaire survey of physicians regarding the impact of the COVID-19 pandemic on patients and treatment system of psychosomatic medicine
Authors: Yamanaka Yukari , Yoshiuchi Kazuhiro , Kubo Chiharu , Fukudo Shin ,   Japanese Society of Psychosomatic Medicine, Kusumi Ichiro , Sato Ken , Ebana Shoichi , Kawai Keisuke , Takeuchi Takeaki , Nakao Mutsuhiro , Hashizume Masahiro , Maruoka Shuichiro , Kaneko Hiroshi , Kawasaki Yasuhiro , Fukunaga Mikihiko , Koyama Atsuko , Hashizume Makoto , Okada Hiroki , Harada Toshihide , Sudo Nobuyuki , Asakawa Akihiro , Matsubayashi Sunao 
Published: June 2023

Abstract
Background
The coronavirus disease 2019 (COVID-19) pandemic has affected the treatment system of medical institutions across the world. Studies of the populations and patients have reported mental health problems caused by the pandemic. However, there are few large-scale studies that have examined the effects of the COVID-19 on diseases from the perspective of psychosomatic medicine. The purpose of this study was to examine changes made to the psychosomatic treatment system of Japan during the COVID-19 pandemic and the impact of the pandemic on patients with diseases treated in psychosomatic medicine.

Methods
We conducted a nationwide questionnaire survey of members of the Japanese Society of Psychosomatic Medicine and the Japanese Society of Psychosomatic Internal Medicine from December 24, 2021 to January 31, 2022.

Results
Of the 325 respondents, 23% reported restrictions in initial outpatient admissions, 66% implemented telemedicine, 46% reported a decrease in outpatient admissions, and 31% working in facilities with inpatient units reported decreased inpatient admissions. To reduce in-person visits, 56% of the respondents decreased the frequency of patient visits and 66% introduced telemedicine. Seventy-eight percent of the respondents reported that the COVID-19 pandemic affected the onset or exacerbation of diseases treated in psychosomatic medicine, including psychosomatic disorders, anxiety disorders, mood disorders, adjustment disorders, and eating disorders.

Conclusions
This study revealed that the COVID-19 pandemic might have affected the practice of psychosomatic treatment in Japan and that various alternative measures were taken to prevent infection. In addition, although the items in this study were not compared to pre-pandemic data, the COVID-19 pandemic, it could have significant psychosocial effects on Japanese patients requiring psychosomatic care. Furthermore, respondents believed that numerous psychosocial factors were behind the impact of the COVID-19 pandemic on patients with diseases treated in psychosomatic medicine.
Values and practice of collaboration in a mental health care system in the Netherlands: a qualitative study
Authors: Kroon Suzanne J.C. , Alma Manna A. , Bak Meike , van der Krieke Lian , Bruggeman Richard 
Published: June 2023

Abstract
Background
To offer optimal care, the mental health system needs new routes for collaboration, involving both interprofessional and interorganizational aspects. The transition from intramural to extramural mental health care has given rise to new dynamics between public and mental health care, introducing a challenge for interprofessional and interorganizational collaboration. This study aims to determine values and expectations of collaboration and to understand how collaboration in mental health care organizations takes shape in daily practice.

Methods
We conducted a qualitative study using semi-structured interviews and a focus group, in the setting of the Program for Mentally Vulnerable Persons (PMV). Data were analysed following thematic analysis.

Results
We found three aspect that were considered important in collaboration: commonality, relationships, and psychological ownership. However, our findings indicate a discrepancy between what is considered essential in collaboration and how this materializes in day-to-day practice: collaboration appears to be less manageable than anticipated by interviewees. Our data suggest psychological ownership should be added as value to the interorganizational collaboration theory.

Conclusion
Our study offers a new definition of collaboration and adding “psychological ownership” to the existing literature on collaboration theory. Furthermore, we gained insight into how collaboration between different organizations works in practice. Our research points to a discrepancy between what all the partners find important in collaboration, and what they actually do in practice. Finally, we expressed ways to improve the collaboration, such as choosing between a chain or a network approach and acting on it and re-highlighting the goal of the Program Mentally Vulnerable persons.
Efficacy and safety of intravenous imatinib in COVID-19 ARDS: a randomized, double-blind, placebo-controlled clinical trial
Authors: Atmowihardjo Leila N. , Schippers Job R. , Duijvelaar Erik , Bartelink Imke H. , Bet Pierre M. , Swart Noortje E. L. , van Rein Nienke , Purdy Keith , Cavalla David , McElroy Andrew , Fritchley Sarah , Vonk Noordegraaf Anton , Endeman Henrik , van Velzen Patricia , Koopmans Matty , Bogaard Harm Jan , Heunks Leo , Juffermans Nicole , Schultz Marcus J. , Tuinman Pieter R. , Bos Lieuwe D. J. , Aman Jurjan 
Published: June 2023

Abstract
Purpose
A hallmark of acute respiratory distress syndrome (ARDS) is hypoxaemic respiratory failure due to pulmonary vascular hyperpermeability. The tyrosine kinase inhibitor imatinib reversed pulmonary capillary leak in preclinical studies and improved clinical outcomes in hospitalized COVID-19 patients. We investigated the effect of intravenous (IV) imatinib on pulmonary edema in COVID-19 ARDS.

Methods
This was a multicenter, randomized, double-blind, placebo-controlled trial. Invasively ventilated patients with moderate-to-severe COVID-19 ARDS were randomized to 200 mg IV imatinib or placebo twice daily for a maximum of seven days. The primary outcome was the change in extravascular lung water index (∆EVLWi) between days 1 and 4. Secondary outcomes included safety, duration of invasive ventilation, ventilator-free days (VFD) and 28-day mortality. Posthoc analyses were performed in previously identified biological subphenotypes.

Results
66 patients were randomized to imatinib (n = 33) or placebo (n = 33). There was no difference in ∆EVLWi between the groups (0.19 ml/kg, 95% CI − 3.16 to 2.77, p = 0.89). Imatinib treatment did not affect duration of invasive ventilation (p = 0.29), VFD (p = 0.29) or 28-day mortality (p = 0.79). IV imatinib was well-tolerated and appeared safe. In a subgroup of patients characterized by high IL-6, TNFR1 and SP-D levels (n = 20), imatinib significantly decreased EVLWi per treatment day (− 1.17 ml/kg, 95% CI − 1.87 to − 0.44).

Conclusions
IV imatinib did not reduce pulmonary edema or improve clinical outcomes in invasively ventilated COVID-19 patients. While this trial does not support the use of imatinib in the general COVID-19 ARDS population, imatinib reduced pulmonary edema in a subgroup of patients, underscoring the potential value of predictive enrichment in ARDS trials.
Trial registrationNCT04794088, registered 11 March 2021. European Clinical Trials Database (EudraCT number: 2020-005447-23).
Multielement analysis coupled with chemometrics modelling for geographical origin classification of teff [Eragrostis tef (Zuccagni) Trotter] grains from Amhara Region, Ethiopia
Authors: Reta Chaltu , Asmellash Tihitinna , Atlabachew Minaleshewa , Mehari Bewketu 
Published: June 2023

AbstractTeff [Eragrostis tef (Zuccagni) Trotter] is an indigenous crop in Ethiopia, and Amhara region is the predominant teff producing region in the country. This study was aimed at developing an analytical methodology useful to determine the geographical origin of teff produced in the Amhara Region, based on multielement analysis combined with multivariate statistical techniques. For this, a total of 72 teff grain samples were collected from three zones (West Gojjam, East Gojjam, and Awi) and analysed for K, Na, Mg, Ca, Mn, Cu, Fe, Co, Ni, Zn, Cr, and Cd contents using inductively coupled plasma-optical emission spectroscopy (ICP-OES). The digestion and ICP-OES analysis method were accurate, with percentage recovery ranging 85.5 to 109% across the different metals analysed. Principal component analysis (PCA) and linear discriminant analysis (LDA) were applied to discriminate samples based on their production regions. Magnesium, Ca, Fe, Mn, and Zn were the most discriminating elements among the samples. The LDA model provided 96% correct classification of samples into production regions and varietal types, with an average prediction ability of 92%. Hence, the multielement analysis combined with statistical modeling can be used in the authentication of the geographical origin and varietal type of teff from Amhara region.
Green construction and release mechanism of lignin-based double-layer coated urea
Authors: Chen Xiaojuan , Yang Huchen , Zhang Lidan , Li Zhongli , Xue Yunna , Wang Rongfeng , Fan Xiaolin , Sun Shaolong 
Published: June 2023

Abstract
Background
Lignin played an important role in the establishment of coated fertilizers coating material as a substitute for petrochemical raw materials. However, so far, the lignin-based coated fertilizers was limited in only the poor slow-release performance. To achieve good slow-release performance of lignin-based coated fertilizers, hydrophilic of lignin need to be resolved to establish an green and better controllable lignin-based coated fertilizers.

Results
In the study, a novel green double layer coating with lignin-based polyurethane (LPU) as the inner coating and epoxy resin (EP) as the outer coating was effectively constructed for coated urea. Fourier transform infrared spectra confirmed that lignin and polycaprolactone diol successfully reacted with Hexamethylene diisocyanate. The loss weight and water contact angle (WCA, 75.6–63.6°) of the LPUs decreased with the increased lignin content. The average particle hardness of the lignin-based double-layer coated urea (LDCU) first increased from 58.1 N (lignin of 30%) to 67.0 N (lignin of 60%), but then decreased to 62.3 N (lignin of 70%). The release longevity of the coated urea was closely related to the preparation parameters of the coating material. The optimal cumulative nutrient release rate (79.4%) of LDCU was obtained (lignin of 50%, –CNO/–OH molar ratios of 1.15, EP of 35%, and coating ratio of 5%). The aggregates of hydrone on the LDCU caused the dissolution and swelling of nutrients, and then the diffusion of nutrients through the concentration gradient.

Conclusions
A though the nutrient release of the LDCUs was affected by many factors, the successful development of the LDCUs will help improve the rapid development of the coated fertilizer industry.
Enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis: ASAS-PerSpA data
Authors: Granados Raquel Ena María , Ladehesa-Pineda M. Lourdes , Puche-Larrubia M. Ángeles , Escudero-Contreras Alejandro , Dougados Maxime , Collantes-Estevez Eduardo , López-Medina Clementina 
Published: June 2023

Abstract
Background
In axial spondyloarthritis (axSpA), peripheral SpA (pSpA) and psoriatic arthritis (PsA), enthesitis is a hallmark clinical feature that can be assessed by the SPARCC index, LEI, MASES and MEI. These indices evaluate different locations, which may identify different numbers of patients with enthesitis among SpA subtypes. Thus, the aim of this study was to evaluate whether the proportion of patients with at least one enthesitis across these three most prevalent SpA subtypes differs according to the index used and to evaluate the level of agreement among indices in detecting patients with enthesitis.

Methods
A total of 4185 patients (2719 axSpA, 433 pSpA and 1033 PsA) from the international and cross-sectional ASAS-PerSpA study were included. The proportion of patients with enthesitis identified by the indices was evaluated across the three diseases. Pairwise agreement between indices was computed using Cohen’s kappa.

Results
The prevalence rates of patients with at least one enthesitis according to the MEI, MASES, SPARCC index and LEI were 17.2%, 13.5%, 10.7%, and 8.3%, respectively. In axSpA, the indices that identified the most patients with enthesitis were the MEI and MASES (98.7% and 82.4%, respectively); in pSpA and PsA, the indices that identified the most patients with enthesitis were the MEI and SPARCC index (MEI: 100% and SPARCC: 84.6%; MEI: 97.3% and SPARCC: 77%, respectively). In the total population, the MASES vs. MEI showed the strongest agreement (absolute agreement 96.3%; kappa: 0.86); similar results were obtained in axSpA patients (97.3%; 0.90). In pSpA and PsA patients, the SPARCC vs. MEI (97.2%; 0.90 and 95.4%; 0.83, respectively) showed the strongest agreement.

Conclusions
These results suggest that the prevalence of patients with enthesitis across SpA subtypes differs depending on the disease and the index used. The MEI and MASES appeared best for assessing enthesis in SpA and axSpA, while the MEI and SPARCC index appeared best for assessing enthesitis in pSpA and PsA.
Valuable effects of lactobacillus and citicoline on steatohepatitis: role of Nrf2/HO-1 and gut microbiota
Authors: El-Baz Ahmed M. , El-Ganiny Amira M. , Hellal Doaa , Anwer Hala M. , El-Aziz Hend A. Abd , Tharwat Ibrahim E. , El-Adawy Mohamed A. , Helal Shehab El-Din M. , Mohamed Menna Tallah A. , Azb Tassnim M. , Elshafaey Hanya M. , Shalata AbdulRahman A. , Elmeligi Sahar M. , Abdelbary Noran H. , El-kott Attalla F. , Al-Saeed Fatimah A. , Salem Eman T. , El-Sokkary Mohamed M. Adel , Shata Ahmed , Shabaan Ahmed A. 
Published: June 2023

AbstractNon-alcoholic steatohepatitis (NASH) is a more dangerous form of chronic non-alcoholic fatty liver disease (NAFLD). In the current investigation, the influence of citicoline on high-fat diet (HFD)-induced NASH was examined, both alone and in combination with Lactobacillus (probiotic). NASH was induced by feeding HFD (10% sugar, 10% lard stearin, 2% cholesterol, and 0.5% cholic acid) to rats for 13 weeks and received single i.p. injection of streptozotocin (STZ, 30 mg/kg) after 4 weeks. Citicoline was given at two dose levels (250 mg and 500 mg, i.p.) at the beginning of the sixth week, and in combination with an oral suspension of Lactobacillus every day for eight weeks until the study’s conclusion. HFD/STZ induced steatohepatitis as shown by histopathological changes, elevated serum liver enzymes, serum hyperlipidemia and hepatic fat accumulation. Moreover, HFD convinced oxidative stress by increased lipid peroxidation marker (MDA) and decreased antioxidant enzymes (GSH and TAC). Upregulation of TLR4/NF-kB and the downstream inflammatory cascade (TNF-α, and IL-6) as well as Pentaraxin, fetuin-B and apoptotic markers (caspase-3 and Bax) were observed. NASH rats also had massive increase in Bacteroides spp., Fusobacterium spp., E. coli, Clostridium spp., Providencia spp., Prevotella interrmedia, and P. gingivalis while remarkable drop in Bifidobacteria spp. and Lactobacillus spp. Co-treatment with citicoline alone and with Lactobacillus improve histopathological NASH outcomes and reversed all of these molecular pathological alterations linked to NASH via upregulating the expression of Nrf2/HO-1 and downregulating TLR4/NF-kB signaling pathways. These results suggest that citicoline and lactobacillus may represent new hepatoprotective strategies against NASH progression.
An environment safety monitoring system for agricultural production based on artificial intelligence, cloud computing and big data networks
Authors: Wei Yunxiao , Han Chao , Yu Zuolong 
Published: June 2023

AbstractMonitoring the agricultural production environment is crucial for optimal crop growth and resource efficiency. Cloud Computing, Artificial Intelligence (AI), and Big Data have revolutionized traditional agriculture, promising improved output and product quality. The popularity of these technologies drives their application in safety monitoring. This system facilitates data collection and transmission among equipment, overcoming challenges of traditional systems like investment, costs, and maintenance. In this paper, cloud computing-based AI optimization technology and big data network were proposed to monitor the safety of the agricultural production environment, and the shortcomings of traditional distance vector hop (DV hop) positioning algorithms were analyzed in depth. RSSI (Received Signal Strength Indication) technology improved the traditional DV Hop location method. The paper analyses direct and indirect transmission for data transmission between WSN and cloud nodes and favors indirect transmission because it consumes less invalid energy. Finally, the article compares several evaluations of alternative algorithms for monitoring system performance, including data transmission reliability, data reception rate, and data delay. The experimental results in this paper showed that in the data reception rate test, the data reception rate of System 2 was 97% at the lowest and 99% at the highest, both exceeding 95%.
Enhanced energy savings in enzymatic refining of hardwood and softwood pulp
Authors: Nagl Martin , Haske-Cornelius Oskar , Bauer Wolfgang , Nyanhongo Gibson S. , Guebitz Georg M. 
Published: June 2023

Abstract
Background
Pulp refining is an energy consuming, but integral part of paper production with the aim to increase tensile strength and smoothness of paper sheets. Commercial enzyme formulations are used to lower the energy requirements by pre-treatment of pulp before refining. However, a high number of different commercial enzyme products are available on the market containing enzymes of varying origin and composition, which complicates the prediction of their behavior, especially using different pulp types.

Results
Endoglucanase-rich enzyme formulations were characterized regarding enzyme activity at different temperatures, resulting in a significant decrease of activity above 70 °C. Some enzyme preparations additionally contained arabinosidase, xylanase and β-glucosidase activity consequently resulting in a release of xylose and glucose from pulp as determined by high-performance liquid chromatography. Interestingly, one enzyme formulation even showed lytic polysaccharide monooxygenase (LPMO) activity of 3.05 nkat mg−1. A correlation between enzyme activity using the endoglucanase specific derivatized cellopentaose (CellG5) substrate and enzyme performance in laboratory PFI (Papirindustriens forskningsinstitut) refining trials was observed on softwood pulp resulting in a maximum increase in the degree of refining values from 27.7°SR to 32.7°SR. When added to a purified endoglucanase enzyme (31.6°SR), synergistic effects were found for cellobiohydrolase II (34.7°SR) or β-glucosidase enzymes (35.7°SR) in laboratory refining. Comparison with previously obtained laboratory refining results on hardwood pulp allowed differences in enzyme performance based on varying pulp types to be elucidated.

Conclusions
Interestingly, the individual enzymes indeed showed different refining effects on softwood and hardwood pulp. This difference could be predicted after development of an adapted enzyme activity assay by combination of the derivatized cellopentaose CellG5 substrate with either softwood or hardwood sulfate pulp.
Symbiotic mycorrhizal types affect patterns of tree aboveground and belowground C allocation in Northeast China
Authors: Wang Qinggui , Yan Guoyong , Luo Xi , Liu Guancheng , Wang Honglin , Xing Yajuan 
Published: June 2023

AbstractBackgroundGiven the ubiquitous nature of mycorrhizal symbioses, different symbiotic fungi have obvious differences in structure and function, which may affect associated tree aboveground and belowground C allocation dynamics. However, the mechanisms underlying tree aboveground and belowground C allocation and its response to symbiotic mycorrhizal types and other factors (e.g., resource availability) remain poorly understood.ResultsWe used forest inventory data to explore the potential mechanism of tree aboveground and belowground C allocation patterns in Northeast China. Our results showed that tree-fungal symbioses were related to the patterns of tree C allocation. The ratio of aboveground to belowground C pool was significantly higher in ectomycorrhizal (EM)-associated trees than that in arbuscular mycorrhizal (AM)-associated trees. Symbiotic mycorrhizal types were associated with the responses of tree aboveground and belowground C allocation to different factors, such as mean annual precipitation (MAP) and mean annual temperature (MAT). Almost all factors significantly increased aboveground C allocation in AM-associated trees but significantly decreased it in EM-associated trees. Moreover, after controlling the other factors, the effects of climate factors (MAT and MAP) on the C allocation of AM- and EM-associated trees were similar. Increases in MAT and MAP significantly increased belowground and aboveground C allocation, respectively.ConclusionsOur results demonstrate symbiotic mycorrhizal types play an important role in controlling tree aboveground and belowground C allocation and dynamics.