bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anlotinib affects systemic lipid metabolism and induces lipid accumulation in human lung cancer cells
Authors: Zhu Zhongling , Xu Shan , Ren Jing , Jiang Teng , Zhang Cai , Yan Zhao 
Published: August 2023

Abstract
Background
Anlotinib has demonstrated encouraging clinical outcomes in the treatment of lung cancer, soft tissue sarcoma and thyroid carcinoma. Several clinical studies have shown a relationship between anlotinib treatment and the occurrence of hyperlipidemia. The fundamental mechanisms, however, are still largely unclear. Here, the effect of anlotinib on lipid metabolism in an animal model and human cancer cells was evaluated and the role of lipid metabolism in the antitumor efficacy of anlotinib was investigated.

Methods
The C57BL/6 J mouse model as well as A549 and H460 human lung cancer cell lines were used to examine the impact of anlotinib on lipid metabolism both in vivo and in vitro. Levels of triglycerides, high-density lipoprotein, low-density lipoprotein (LDL), and total cholesterol in serum or cell samples were determined using assay kits. The expression levels of crucial genes and proteins involved in lipid metabolism were measured by quantitative RT-PCR and Western blotting. Furthermore, exogenous LDL and knockdown of low-density lipoprotein receptor (LDLR) were used in H460 cells to investigate the relevance of lipid metabolism in the anticancer efficacy of anlotinib.

Results
Anlotinib caused hyperlipidemia in C57BL/6 J mice, possibly by downregulating hepatic LDLR-mediated uptake of LDL cholesterol. AMP-activated protein kinase and mammalian target of rapamycin inhibition may also be involved. Additionally, anlotinib enhanced sterol response element binding protein 1/2 nuclear accumulation as well as upregulated LDLR expression in A549 and H460 cells, which may be attributable to intracellular lipid accumulation. Knockdown of LDLR reduced intracellular cholesterol content, but interestingly, anlotinib significantly improved intracellular cholesterol accumulation in LDLR-knockdown cells. Both exogenous LDL and LDLR knockdown decreased the sensitivity of cells to anlotinib.

Conclusions
Anlotinib modulates host lipid metabolism through multiple pathways. Anlotinib also exerts a significant impact on lipid metabolism in cancer cells by regulating key transcription factors and metabolic enzymes. In addition, these findings suggest lipid metabolism is implicated in anlotinib sensitivity.
A multi-functional hypoxia/esterase dual stimulus responsive and hyaluronic acid-based nanomicelle for targeting delivery of chloroethylnitrosouea
Authors: Li Duo , Ren Ting , Ge Yunxuan , Wang Xiaoli , Sun Guohui , Zhang Na , Zhao Lijiao , Zhong Rugang 
Published: August 2023

AbstractCarmustine (BCNU), a vital type of chloroethylnitrosourea (CENU), inhibits tumor cells growth by inducing DNA damage at O6 position of guanine and eventually forming dG-dC interstrand cross-links (ICLs). However, the clinical application of BCNU is hindered to some extent by the absence of tumor selectivity, poor stability and O6-alkylguanine-DNA alkyltransferase (AGT) mediated drug resistance. In recent years, tumor microenvironment has been widely utilized for advanced drug delivery. In the light of the features of tumor microenvironment, we constructed a multifunctional hypoxia/esterase-degradable nanomicelle with AGT inhibitory activity named HACB NPs for tumor-targeting BCNU delivery and tumor sensitization. HACB NPs was self-assembled from hyaluronic acid azobenzene AGT inhibitor conjugates, in which O6-BG analog acted as an AGT inhibitor, azobenzene acted as a hypoxia-responsive linker and carboxylate ester bond acted as both an esterase-sensitive switch and a connector with hyaluronic acid (HA). The obtained HACB NPs possessed good stability, favorable biosafety and hypoxia/esterase-responsive drug-releasing ability. BCNU-loaded HACB/BCNU NPs exhibited superior cytotoxicity and apoptosis-inducing ability toward the human uterine cervix carcinoma HeLa cells compared with traditional combined medication of BCNU plus O6-BG. In vivo studies further demonstrated that after a selective accumulation in the tumor site, the micelles could respond to hypoxic tumor tissue for rapid drug release to an effective therapeutic dosage. Thus, this multifunctional stimulus-responsive nanocarrier could be a new promising strategy to enhance the anticancer efficacy and reduce the side effects of BCNU and other CENUs.
Clinical characteristics and survival prediction of surgical patients with invasive pancreatic cystic neoplasm: a large retrospective study over two decades
Authors: Song Yanjing , Li Zhe , Cui Hongyuan , Xu Jingyong , Song Jinghai 
Published: August 2023

Abstract
Purposes
Invasive pancreatic cystic neoplasms (iPCNs) are an uncommon and biologically heterogeneous group of malignant neoplasms. We aimed to investigate the clinicopathological characteristics of iPCN patients and to develop nomograms for individual survival prediction after radical surgery.

Methods
Data of patients diagnosed with iPCN and pancreatic ductal adenocarcinoma (PDAC) between 2000 and 2018 from the SEER database were retrieved. The differences in clinical outcomes were evaluated using the Kaplan–Meier analysis. Nomograms were proposed based on the Cox regression model and internally validated by C-index, area under the curve (AUC) value, and calibration plot.

Results
A total of 7777 iPCN patients and 154,336 PDAC patients were enrolled. Most neoplasms were advanced, with 63.1% at stage IV. The 3-year overall survival (OS) and cancer-specific survival (CSS) rates in surgical patients were as follows: 45.7% and 50.1% for invasive intraductal papillary mucinous neoplasm (IPMN), 54.8% and 59.3% for invasive mucinous cystic neoplasm (MCN), 97.8% and 98.2% for invasive solid pseudopapillary neoplasm (SPN), 88.9% and 88.9% for invasive serous cystic neoplasm (SCN), and 27.3% and 30.5% for PDAC. Subgroup analyses showed no clinical benefit from chemotherapy or radiotherapy in lymph node-negative iPCN patients who underwent surgery. The following variables associated with OS and CSS were identified: age, race, chemotherapy, radiotherapy, histologic type, pathological grade, regional nodes examined, and T, N, and M stage. The nomograms had good discrimination and calibration by internal validation, with an AUC value of 0.800 for 3-year OS and 0.814 for 3-year CSS.

Conclusion
Our study showed that the prognosis of iPCN patients was significantly better than PDAC patients. The proposed nomograms demonstrated substantially better discrimination and calibration.
Understanding the healthcare provider role on post abortion contraception adoption in India using National Family Health Survey-5
Authors: Bansal Anjali , Kullu Arpana , Dixit Priyanka 
Published: August 2023

Abstract
Background
Post abortion contraceptive use is an important area in provisioning of services associated with child birth planning. This study examines the factors related to the type and timing of initiation of contraception adoption among women who had undergone induced abortion. Study also tries to identify the role of personnel who provided the abortion service on decision of family planning adoption using complementary log–log model in India.

Methodology
The study uses the secondary data from the fifth round of the National Family Health Survey conducted during 2019–21. For, the analysis, we have used five-year women’s reproductive calendar to extract information on contraceptive use, post last induced abortion among women. We used complementary log–log regression models, to estimate relative risk ratios and its 95% Confidence intervals (CI).

Results
According to NFHS-5, out of all the last pregnancies (2,55,549), about three percent resulted in abortion. Most of the abortion occurred in private facilities (55%), with the help of health professionals (71%). From the women’s reproductive calendar, it was found that around 40% of the women adopted modern methods of contraception, with maximum adopting spacing method (33%), and only handful adopted permanent method (7%). It was also found that the likelihood of early adoption of permanent method increased to two times when the abortion is done by health professional compared to others [95% CI (1.25–3.30)].

Conclusion
This emphasises a need for quality counselling related to timing and types of family planning as an essential part of the family planning program ensuring client centric approach suited to their needs and contexts that helps in alleviating any apprehensions associated with adverse effects of modern contraceptive methods.
Clinical presentation of Warburg effect in aggressive lymphoma: a case report
Authors: Cao Yenong , Liu Margaret C. , Hanlon Emma L. , Chen York , Afzal Muhammad Z. , Hayes Christi A. , Hill John M. 
Published: August 2023

Abstract
Background
The Warburg effect is a rare condition in tumor biology, illustrated by significant lactate production in the presence of oxygen. The Warburg effect is associated with very poor prognosis in patients with malignancy.

Case presentation
We report a 76-year-old Caucasian woman with double-expressor diffuse large B cell lymphoma who presented with severe lactic acidosis and extreme hypoglycemia with normal mentation. Her lactic acidosis was initially controlled with a bicarbonate infusion, and the patient was started promptly on steroids, followed by chemotherapy, but her clinical course was complicated by tumor lysis syndrome, acute renal failure requiring hemodialysis, and progressive liver failure. She manifested a temporary clinical response to chemotherapy but eventually died of complications.

Conclusions
This case demonstrates the importance of prompt recognition of the Warburg effect, aggressive supportive measures, and early initiation of chemotherapy. Future studies are needed to characterize the role of hemodialysis in this setting.
The anxiety associated with COVID-19, general health, spiritual health, and job satisfaction in healthcare providers: a cross-sectional study
Authors: Roshani Daem , Saboni Keivan , Amjadian Mohiadin 
Published: August 2023

Abstract
Background
Previous research has shown the impact of pandemic communicable diseases on the mental health of healthcare providers. This study examined the relationship between general health, spiritual health, anxiety associated with COVID-19, job satisfaction, and the mediating role of sex in healthcare providers in Iran in 2021.

Methods
This was a descriptive-analytical and cross-sectional study performed on 163 healthcare providers of which 71.8% were female and 28.2% were male with an age range between 21 and 58 years, an average work experience of 9.5 years, and working as nurses, doctors, laboratory technicians, etc. in some hospitals in Sanandaj. Data were collected using COVID-19 Anxiety, General Health, job satisfaction, and Spiritual Health questionnaires. Then, the data were analyzed using SPSS-22 software, regression test, and path analysis.

Results
Although women averaged lower levels of general health, job satisfaction, and anxiety associated with COVID-19, and higher scores in spiritual health than men, none of these differences were statistically significant, and sex didn’t play a significant role here. Also, general health and spiritual health could significantly predict 17.1% of the variance in job satisfaction in the path analysis. However, sex and Covid-19 anxiety could not significantly predict this variable.

Conclusion
The results showed that there was not a significant difference between the male and female workers’ general health when facing such pandemics. However, we may prepare interventions to promote their general and spiritual health and to promote healthcare providers’ job satisfaction during such pandemics.
Exploring the emotional impact of axial Spondyloarthritis: a systematic review and thematic synthesis of qualitative studies and a review of social media
Authors: Wilson Nicky , Liu Jia , Adamjee Qainat , Di Giorgio Sonya , Steer Sophia , Hutton Jane , Lempp Heidi 
Published: August 2023

Abstract
Background
The psychological burden in people with inflammatory arthritis is substantial, yet little is known about the disease-related affect experienced by individuals with axial Spondyloarthritis (axial SpA). The aim of this study was to conduct a qualitative evidence synthesis and a review of social media to explore the emotional impact of living with axial SpA.

Methods
We searched nine databases for studies reporting qualitative data about participants’ emotional experience of living with axial SpA. In addition, we searched social media platforms for posts from people with axial SpA based in the UK that offered insights into emotional responses to living with the condition. We employed a thematic approach to synthesise the data.

Results
We included 27 studies (1314 participants; 72% men) in our qualitative evidence synthesis and developed seven descriptive themes from the data: 1) delayed diagnosis: a barrier to emotional wellbeing; 2) disruptive symptoms: a source of mood swings; 3) work disability: a loss of self-esteem; 4) obstacles in interpersonal relationships: a trigger of distress; 5) taking up exercise: personal pride or unwelcomed reminders; 6) anti-TNF therapy: hope reignited despite concerns and 7) a journey of acceptance: worry mixed with hope. Posts extracted from social media fora (537; 48% from women) for the most part supported the seven themes. One additional theme—COVID-19, uncertainty and anxiety during the pandemic, was developed, reflecting common emotions expressed during the UK’s first wave of the coronavirus pandemic.

Conclusion
This study highlights a preponderance of negative affect experienced by people living with axial SpA, conditioned through existing and anticipated symptoms, failed expectations, and lost sense of self. Given the bidirectional relationships between negative emotions and inflammation, negative emotions and perceptions of pain, and the influence of affect in self-care behaviours, this finding has important implications for treatment and management of people with axial SpA.
Evaluation of perception of music, environmental sounds, and speech in right versus left cerebral stroke patients
Authors: Abdel Hady Aisha Fawzy , Shohdi Sahar Saad , Shawky Ayman Mohamed , Abusenna Mohammed Ibrahem 
Published: August 2023

Abstract
Background
Stroke is a leading cause of disability and about a third of stroke survivors have aphasia. Stroke also may affect all levels of the auditory pathway and lead to hearing reception and/or perception deficits for different sound types.

Aim of the work
The aim of the work is to evaluate the perception of music, environmental sounds, and speech in post-stroke patients in order to determine if there is a difference in the basic auditory perceptual abilities in right versus left cerebral stroke.

Subjects and methods
A group of 30 healthy adults and a group of 30 right and left cerebral stroke patients with an age range from 35 to 75 years old were included. The participants were evaluated using a 10-item designed questionnaire for auditory abilities and a test of auditory perceptual/recognition skills. The questionnaire addressed some of the basic auditory skills of attention, discrimination, and recognition of environmental sounds and human voice. The test consisted of non-verbal and verbal domains. The non-verbal domain involved music recognition, discrimination, perception, performance, and environmental sound recognition tasks. While the verbal domain included; recognition of the sound related to speech stimuli and syllable/word recognition tasks.

Results
Better significant scores in right versus left stroke patients regarding questionnaire results for attention to sound sources either near or fear (p value < 0.001) and discriminating prosodic intonation of statement or interrogation (p value =  < 0.001). There was no significant difference between the right cerebral stroke group and the left cerebral stroke group regarding the score of music perception and music performance tasks of the non-verbal domain of the auditory perceptual/recognition skills assessment. Better significant scores were found in the right cerebral stroke patients than the left cerebral stroke patients regarding the scores of both the non-verbal and verbal domains of the auditory perceptual/recognition skills assessment.

Conclusion
Stroke of both right and left cerebral hemispheres has a specific negative effect on some aspects of perception of music, environmental sounds, and speech that need to be addressed in both evaluation protocols and rehabilitation programs.
The Medieval of the Long Now
Authors: Warren Michelle R. 
Published: August 2023

Abstract
As decades turn to centuries to millennia, the contemporary relationship with the past is increasingly medieval. This article takes the perspective of extreme long-term thinking to reexamine how medieval studies can interact with more contemporary fields. How might scholars share the “now” with each other and with their predecessors from other millennia? And how might this perspective transform racial epistemologies? Inspired by the millennial thinker, Henry of Huntingdon (d. 1157), the article connects the Long Now Foundation, the 10,000-Year Clock, the poet T. S. Eliot, and the near future called the “digital Dark Ages.” Henry from the twelfth century provides a recent antecedent for imagining the “long now” wrought by settler colonialism. Undoing periodization directly challenges the colonizing deployment of time itself.
Undoing Medieval Race Studies
Authors: Min Mariah 
Published: August 2023

Abstract
This essay argues that “medieval race”—which has been gaining a recent foothold in medieval studies—is counterproductive as a concept because it occludes the mobility of race. Mobility here refers to the way that race takes on multiple forms within the same historical moment, including skin color, language, religion, ethnicity, and systemic power. “Medieval race” erroneously presumes that there is only one form of race in the Middle Ages, which can be compared to a similarly fictitious singular “modern race.” This inattention to mobility creates misapprehensions about how race functions across time; therefore, race scholars must reach beyond their siloed disciplines to work collaboratively, so that they can articulate and disseminate theorizations of race that are grounded in transhistorical study.
A Part of the Heart Can't Be Eaten
Authors: Taormino Tristan 
Published: August 2023

In A Part of the Heart Can't Be Eaten, award-winning author, sex educator, filmmaker, and podcast host Tristan Taormino shares her coming-of-age story, revealing how her radical sexuality and unconventional career grew out of an extraordinary queer father-daughter relationship. Raised by a hard-working single mother on Long Island, Tristan got her sex ed from the 1980s TV show Solid Gold and The Joy of Sex. She spent summers at drag shows in Provincetown with her father, Bill, who had come out as gay in the mid-1970s. Her sexual identity bloomed during her college years at Wesleyan University, where she discovered her desire for butches and kinky sex.
Tristan's world began to fall apart when her dad was diagnosed with AIDS. After a series of devastating events, she moved to the messy, glorious world of 1990s New York City. In the midst of grief and depression, she helped change queer sexual subculture with her zine Pucker Up, her infamous The Village Voice column, and her editorship of legendary lesbian porn magazine On Our Backs. After the publication of her first book, The Ultimate Guide to Anal Sex for Women, Tristan followed her own path that marked the beginning of her work as a trailblazing feminist pornographer.
After a lifetime of outrageous adventures, Tristan reflects on the bonds, loss, and mental-health struggles that shaped her. She weaves together history from her father's unpublished memoir, exploring the surprising ways their personal patterns converge and diverge. Bracingly emotional and erotically charged, A Part of the Heart Can't Be Eaten reveals the transformative power of queer pleasure and defiance.
The impact of the introduction of selective screening in the UK on the epidemiology, presentation, and treatment outcomes of developmental dysplasia of the hip
Authors: Poacher Arwel T. , Hathaway Isaac , Crook Daniel L. , Froud Joseph L. J. , Scourfield Lily , James Catherine , Horner Matthew , Carpenter Eleanor C. 
Published: August 2023

AimsDevelopmental dysplasia of the hip (DDH) can be managed effectively with non-surgical interventions when diagnosed early. However, the likelihood of surgical intervention increases with a late presentation. Therefore, an effective screening programme is essential to prevent late diagnosis and reduce surgical morbidity in the population.MethodsWe conducted a systematic review and meta-analysis of the epidemiological literature from the last 25 years in the UK. Articles were selected from databases searches using MEDLINE, EMBASE, OVID, and Cochrane; 13 papers met the inclusion criteria.ResultsThe incidence of DDH within the UK over the last 25 years is 7.3/1,000 live births with females making up 86% of the DDH population (odds ratio 6.14 (95% confidence interval 3.3 to 11.5); p < 0.001). The incidence of DDH significantly increased following the change in the Newborn and Infant Physical Examination (NIPE) guidance from 6.5/1,000 to 9.4/1,000 live births (p < 0.001). The rate of late presentation also increased following the changes to the NIPE guidance, rising from 0.7/1,000 to 1.2/1,000 live births (p < 0.001). However, despite this increase in late-presenting cases, there was no change in the rates of surgical intervention (0.8/1,000 live births; p = 0.940).ConclusionThe literature demonstrates that the implementation of a selective screening programme increased the incidence of DDH diagnosis in the UK while subsequently increasing the rates of late presentation and failing in its goal of reducing the rates of surgical intervention for DDH.Cite this article: Bone Jt Open 2023;4(8):635–642.