bluuebunny/crossref_metadata_2025_split huggingface dataset:
Camrelizumab plus gemcitabine and oxaliplatin for the treatment of advanced intrahepatic cholangiocarcinoma: a bi-centric observational retrospective study
Authors: Zhang Yu-Qing , Wang Kang , Feng Jin-Kai , Yuan Lu-Yun , Liang Chao , Xiang Yan-Jun , Wang Xu , Mao Fei-Fei , Cheng Shu-Qun 
Published: May 2023

BackgroundImmune checkpoint inhibitor (ICI), coupled with systemic chemotherapy, may enhance the clinical benefit of cancer by potentiating antitumor immunity, but its efficacy and safety are not clear in advanced intrahepatic cholangiocarcinoma (ICC). This study aims to assess the efficacy and safety of camrelizumab plus gemcitabine and oxaliplatin (GEMOX) for the treatment of advanced ICC in the real world.MethodsAdvanced ICC patients receiving at least one session of camrelizumab plus GEMOX combination treatment from March 2020 to February 2022 at two high-volume centers were considered eligible. Tumor response was evaluated based on the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1). The primary endpoint was objective response rate (ORR), disease control rate (DCR), time to response (TTR), and duration of response (DOR). The secondary end points included overall survival (OS), progression-free survival (PFS), and treatment-related adverse events (TRAEs).Results30 eligible ICC patients were enrolled and analyzed in this observational retrospective study. The median follow-up time was 24.0 (21.5–26.5) months. The ORR and DCR were 40% and 73.3%, respectively. The median TTR was 2.4 months and the median DOR was 5.0 months. The median PFS and OS were 7.5 months and 17.0 months, respectively. The most common TRAEs were fever (83.3%), fatigue (73.3%), and nausea (70%). Of all TRAEs, thrombocytopenia, and neutropenia were the most frequent severe AE (both 10%).ConclusionThe combination of camrelizumab and GEMOX is a potentially efficacious and safe treatment modality for advanced ICC patients. Potential biomarkers are needed to identify patients who might benefit from this treatment option.
Identifying key transcription factors and immune infiltration in non-small-cell lung cancer using weighted correlation network and Cox regression analyses
Authors: Zhang Jingyao , Wang Yinuo , Yuan Baowen , Qin Hao , Wang Yong , Yu Hefen , Teng Xu , Yang Yunkai , Zou Jun , Zhang Min , Huang Wei , Wang Yan 
Published: May 2023

IntroductionLung cancer is one of the most common cancers and a significant cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer cases. Therefore, it is crucial to identify effective diagnostic and therapeutic methods. In addition, transcription factors are essential for eukaryotic cells to regulate their gene expression, and aberrant expression transcription factors are an important step in the process of oncogenesis in NSCLC.MethodsDifferentially expressed transcription factors between NSCLC and normal tissues by analyzing mRNA profiling from The Cancer Genome Atlas (TCGA) database program were identified. Weighted correlation network analysis (WGCNA) and line plot of least absolute shrinkage and selection operator (LASSO) were performed to find prognosis-related transcription factors. The cellular functions of transcription factors were performed by 5-ethynyl-2'-deoxyuridine (EdU) assay, wound healing assay, cell invasion assay in lung cancer cells.ResultsWe identified 725 differentially expressed transcription factors between NSCLC and normal tissues. Three highly related modules for survival were discovered, and transcription factors highly associated with survival were obtained by using WGCNA. Then line plot of LASSO was applied to screen transcription factors related to prognosis and build a prognostic model. Consequently, SETDB2, SNAI3, SCML4, and ZNF540 were identified as prognosis-related transcription factors and validated in multiple databases. The low expression of these hub genes in NSCLC was associated with poor prognosis. The deletions of both SETDB2 and SNAI3 were found to promote proliferation, invasion, and stemness in lung cancer cells. Furthermore, there were significant differences in the proportions of 22 immune cells between the high- and low-score groups.DiscussionTherefore, our study identified the transcription factors involved in regulating NSCLC, and we constructed a panel for the prediction of prognosis and immune infiltration to inform the clinical application of transcription factor analysis in the prevention and treatment of NSCLC.
Case Report: Primary lymphoepithelioma-like intrahepatic cholangiocarcinoma
Authors: Liu Fei , Xu Qing , Regmi Parbatraj , Li Fu-Yu , Lin Yi-Xin 
Published: May 2023

BackgroundLymphoepithelioma-like intrahepatic cholangiocarcinoma (LEL-ICC) is a rare variant of intrahepatic cholangiocarcinoma. Epstein–Barr virus (EBV) infection was considered to play a pivotal role in the tumorigenesis of LEL-ICC. It is difficult to diagnosis of LEL-ICC due to the lack of specific features regarding the laboratory test results and imaging findings. At present, the diagnosis of LEL-ICC mainly depends on the histopathologic and immunohistochemical examinations. In addition, the prognosis of LEL-ICC was better than classical cholangiocarcinomas. To our knowledge, only few cases of LEL-ICC have been reported in the literature.Case presentationWe presented a case of a 32-year-old Chinese female with LEL-ICC. She had a 6-month history of upper abdominal pain. The magnetic resonance imaging (MRI) showed a 1.1× 1.3 cm lesion in the left lobe of liver, appearing low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. The patient underwent laparoscopic left lateral sectionectomy. The postoperative histopathologic and immunohistochemical examinations results allowed for the definitive diagnosis of LEL-ICC. The patient was free from tumor recurrence after a 28 months follow-up.ConclusionIn this study, we reported a rare case of LEL-ICC associated with both HBV and EBV infection. EBV infection might play a pivotal role in the carcinogenesis of LEL-ICC, and surgical resection is still the most effective treatment at present. Further research on the etiology and treatment strategies of LEL-ICC is required.
Were Arenga Palms (Arecaceae) Present in the Eocene? A Review of the Genus Succinometrioxena Legalov, 2012
Authors: Legalov Andrei A. 
Published: May 2023

It has been suggested that palms of the genus Arenga (Arecales: Arecaceae) or forms close to it were distributed in the Eocene of North America and Europe. Records of Metrioxenini (Belidae), which are monophages on these palms, confirm this assumption. A new species, Succinometrioxena andrushchenkoi Legalov, sp. n. from Baltic amber is described. The new species differs from S. poinari Legalov, 2012 in the smaller body sizes, elytral punctation larger than the distances between them, and a rostrum weakly curved in females. It is distinguished from S. bachofeni Legalov, 2013 and S. attenuata Legalov et Poinar, 2020 by the forehead lacking horn-like tubercles on either side of the eyes. A description of male of S. poinari was herein compiled for the first time. A list and key to fossil Metrioxenini were given. The modern and fossil distribution of the tribe Metrioxenini and Arenga palms was shown.
Transverse Deflection for Extreme Ultraviolet Pellicles
Authors: Kim Sang-Kon 
Published: May 2023

Defect control of extreme ultraviolet (EUV) masks using pellicles is challenging for mass production in EUV lithography because EUV pellicles require more critical fabrication than argon fluoride (ArF) pellicles. One of the fabrication requirements is less than 500 μm transverse deflections with more than 88% transmittance of full-size pellicles (112 mm × 145 mm) at pressure 2 Pa. For the nanometer thickness (thickness/width length (t/L) = 0.0000054) of EUV pellicles, this study reports the limitation of the student’s version and shear locking in a commercial tool-based finite element method (FEM) such as ANSYS and SIEMENS. A Python program-based analytical-numerical method with deep learning is described as an alternative. Deep learning extended the ANSYS limitation and overcame shear locking. For EUV pellicle materials, the ascending order of transverse deflection was Ru<MoSi2=SiC<SiNx<ZrSr2<p-Si<Sn in both ANSYS and a Python program, regardless of thickness and pressure. According to a neural network, such as the Taguchi method, the sensitivity order of EUV pellicle parameters was Poisson’s ratio<Elastic modulus<Pressure<Thickness<Length.
Long-Term Care Healthcare-Associated Infections in 2022: An Analysis of 20,216 Reports
Authors: Kepner Shawn , Bingman Christine , Jones Rebecca 
Published: May 2023

Background The Pennsylvania Patient Safety Reporting System (PA-PSRS) is the largest database of patient safety event reports in the United States. In addition to over 4.5 million acute care reports, the PA-PSRS database contains more than 396,000 long-term care (LTC) healthcare-associated infection (HAI) reports. Methods LTC HAI data from PA-PSRS were extracted on March 1, 2023. Reports submitted by LTC facilities and specific care areas were included for infection rates each month if resident and device days were also entered in PA-PSRS for the facility and care area. Results A total of 20,216 infections were reported in 2022, representing a 12.5% increase from 2021. Overall, the reporting rate from LTC facilities increased from 0.77 in 2021 to 0.87 in 2022. Over half (56%) of the increase in overall rate is due to an increase in the respiratory tract infection rate, with another 27% due to an increase in the gastrointestinal infection rate. All six regions of the state had an increase in overall infection rate from 2021 to 2022. The North Central region of the state had the highest overall rate, as well as the largest increase in rate, with 1.14 reports per 1,000 resident days in 2022, which is an increase of 21.3% over the 2021 rate of 0.94. The Southeast region had the lowest overall rate, at 0.67, which is an 8.1% increase from 2021. The number of reports increased for all five infection types from 2021 to 2022, with gastrointestinal infections increasing the most percentagewise, by 67.7%. Of the 14 infection subtypes, 11 had an increase in number of reports from 2021 to 2022, with influenza showing the largest increase of 857 reports. Norovirus had a larger percentage increase of 942.9%, going from 70 reported infections in 2021 to 730 in 2022. The three subtypes that decreased in number had relatively smaller changes than the increases, with the largest of the decreases occurring with C. diff, which dropped by 29 reports from 2021 to 2022. Conclusions There was an increase in the total number and rate of infections reported to PA-PSRS in 2022. Patient Safety Authority infection preventionists continue to note operational challenges in LTC facilities and are providing ongoing education and guidance to enhance infection prevention and surveillance strategies and improve reporting of HAIs.
Atendimento odontológico: ansiedade durante a cirurgia odontológica
Authors: De Menezes Vinicius Cesar Barbosa , Figueiredo Paloma Faria , Figueiredo Laura Gomes Batista , Carvalho Thamiris Pimenta , Silva Isadora Oliveira Pinto Alves , Bomfim Evely Matos 
Published: May 2023

Introdução: A ansiedade é um grande desafio durante o tratamento odontológico. Para alguns pacientes, cirurgias em odontologia podem gerar alterações emocionais, tais como medo e ansiedade, impactando assim no tratamento, na qual pode ocorrer susceptíveis urgências ou emergências odontológicas. Objetivo: Apresentar situações que geram ansiedade durante o tratamento odontológico, além de métodos farmacológicos e não farmacológicos para controle da ansiedade. Revisão de literatura: Utilizou-se artigos encontrados nas bases de dados como Pubmed/Medline, Scielo e google acadêmico. Artigos publicados de acordo com critérios de inclusão, texto completo, período de publicação e detalhamento metodológico. Conclusão: Conclui-se que o controle da ansiedade é importante para o bem-estar do paciente durante e após o tratamento odontológico, e o cirurgião dentista deve buscar auxílio para tratar essa condição através de métodos farmacológicos e não farmacológicos.
Análise de rotulagens de marcas de suplementos de proteína do soro do leite em pó (Whey Protein) segundo a RDC N° 18, 27 de abril de 2010
Authors: Bezerra Alane Nogueira , Dos Santos Bruna Saraiva , Pereira Camila Pinheiro , Lopes Euclides David Rodrigues , Da Costa Hugo Leonardo Barroso , Gomes Isabela Limaverde , Amâncio Lívia Carolina , Melo Mateus Azevedo Ursulino 
Published: May 2023

A indústria de suplementos alimentares cresceu nos últimos anos, principalmente a venda de suplementos à base de proteínas em pó e estas são bastante utilizadas por praticantes de musculação, interessados pelo ganho de massa muscular. Com o intuito de prevenir a utilização indiscriminada do consumo de suplementos proteicos por praticantes de atividade física, o presente estudo objetivou avaliar os rótulos de proteína do soro do leite `` whey protein ´´ comercializados em lojas de Fortaleza – CE, segundo os padrões RDC n° 18, 27 de abril de 2010. Trata-se de um estudo quantitativo, exploratório e descritivo, onde realizou –se uma análise de diferentes marcas de suplementos proteicos do soro do leite. As amostras foram selecionadas conforme indicação de suplementos proteicos, sendo analisadas de acordo com disponibilidade das lojas, do município de Fortaleza – CE. Foram avaliadas 20 marcas, destas, apenas 80% estavam conforme a legislação, enquanto 20% estavam em desacordo. Com relação às não conformidades, destacou –se a ausência da informação `` As expressões: anabolizantes, hipertrofia muscular ´´ em 20% dos rótulos, quanto a designação ``Imagens e ou expressões referentes a perda de peso, ganho de massa muscular ́ ́ 10% estavam em desacordo. Quanto à adição de fibras, 75 % estavam em desacordo com a legislação. Com isso, destaca-se, a necessidade de fiscalização contínua e eficaz dos rótulos de suplementos destinados a atletas e praticantes de atividade física, com garantia de que os consumidores tenham acesso a informações fidedignas sobre o produto. Conclui-se que grande parte dos rótulos de suplementos proteicos para atletas apresentavam algum tipo de inadequação de acordo com o objetivo proposto.
Acción génica en líneas contrastantes de maíz (Zea mayz L.)
Authors: Banda Armando Espinoza , Grijalva Oralia Antuna , Rodríguez José Luis Coyac , Enríquez Enrique Andrio 
Published: May 2023

El objetivo fue estimar los efectos de aptitud combinatoria general (ACG) y la aptitud combinatoria específica (ACE) en líneas de maíz y sus cruzas. Se utilizaron nueve líneas de maíz, divididas en dos grupos: el primero, como machos, formado por cuatro líneas de la Universidad Autónoma Agraria Antonio Narro Unidad Laguna (UAAAN-UL) derivadas de la Población-60 que se caracterizan por su adaptación a la Comarca Lagunera. El segundo, dos líneas recicladas del banco de germoplasma de CIMMYT (L25 y L26 de ciclo precóz-Intermedio, de grupo heterótico A adaptadas al Sub trópico y, tres líneas (L23, L27 y L28) de la UAAAN-UL que provienen de la cruza de Población-61 x LAN 388P línea enana, con hojas anchas y verticales generada a partir de la tercera generación del híbrido AN-388. En 2013 se generaron 20 cruzas por el método II de Carolina del Norte. Se evaluaron en abril de 2014 en un diseño de bloques al azar, dos repeticiones y riego normal. La parcela fue de dos surcos de 3.0 m de largo y 0.75 m de ancho y 0.17 m entre planta, una densidad de 78, 431 plantas por hectárea. Se fertilizó con la fórmula 180-90-00. Se tomaron datos de Floración masculina (FM), Femenina (FF), Altura de planta (AP) y Mazorca (AMz), dimensiones de mazorca: diámetro DMz), longitud (LMz), numero de hileras (NH) y granos por hilera (GH) y, rendimiento de grano (Rend). Los 20 híbridos experimentales fueron significativamente diferentes (p≤0.01) en nueve de las variables. Los probadores machos (M), fueron diferentes (p≤0.05) en floración femenina (FF) y altamente significativa (p≤0.01) para floración masculina (FM) y longitud de mazorca (LMz), en tanto que el resto fue no-significativo (AP, AM, HMz, GH, DMz y Rend). En contraste, las hembras (H), mostraron mayor diversidad, pues se observaron diferencias (p≤0.05) para hileras por mazorca (HM) y, diferencias altamente significativas (p≤0.01) para: FM, FF, AP, LMz, GH, DMz y Rend. En las líneas hembra se observó mayor diversidad que en los machos usados como probadores. La interacción MxH fue significativamente diferente para FF y dimensiones de la mazorca (LMz, GH y DMz) además de Rend. Tres de las Líneas Macho (L1, L2, L3) mostraron ACG positiva y significativa para Rend, en cambio en las hembras solo las L23 y L28 fueron significativas. Los mayores efectos de ACE positivos y significativos se observaron en seis de las 20 cruzas donde 2x26, 5x26 y 6x28 mostraron los mayores rendimientos de grano. La acción génica aditiva y no-aditiva fueron de importancia en el presente estudio.
Gestión Sostenible de Riesgos de Desastres de los Gobiernos Regionales, Locales (Provincias – Distritos), Poder Ejecutivo
Authors: Sandoval Jorge Lescano , Sena Lucía Emperatriz Valdéz , Vega Marlitt Florinda Naupay 
Published: May 2023

Se presenta la frondosa normativa que se aplica en el Perú para efectos de una eficaz y eficiente gestión de riesgos de desastres naturales. A la luz de dicha normativa se requiere con urgencia replantear la gestión, sobre la base de un estudio del medio físico. Por otro lado, es necesario un mayor conocimiento de la normativa sobre todo los entes decisores (autoridades).
Pengaruh Motivasi Dan Disiplin Kerja Terhadap Kinerja Pengawai Pada Kantor Camat Kecamatan Sanga Desa
Authors: Heriyana Heriyana , Erlina Neti 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui Seberapa pesar pengaruh Motivasi dan disiplin kerja pagawai terhadap kinerja pegawai Kantor Camat Kecamatan Sanga Desa. Penelitian ini mengggunakan data primer maupun sekunder. Teknik analisis penelitian ini menggunakan metode kuantitatif dimana menggunakan persamaan statistika dalam mengolah dan melakukan pembahasan data yang diperoleh dari responden melalui media kuesioner. Metode analisis yang digunakan adalah menggunakan Metode Regresi Linear Berganda. Hasil penelitian ini menunjukkan bahwa Nilai r sebesar 0,561. Hal ini menunjukkan bahwa terjadi hubungan yang sedang antara motivasi (X1) dan disiplin kerja (X2) terhadap kinerja pegawai (Y). Karena nilai R berada pada rentang 0,400 sampai dengan 0,599 dengan intepretasi koefisien kolerasi sedang. Diketahui nilai Adjusted R Square sebesar 0,395, maka memiliki arti bahwa variable motivasi dan disipli kerja memberikan sumbangan pengaruh secara bersama-sama sebesar 39,5% terhadap variable kinerja pegawai dan sisanya 60,5% dipengaruhi variable lain di luar penelitian ini. Hasil uji t (Test) menunjukkan bahwa variabel motivasi (X1) thitung sebesar 1,189 sedangkan ttabel pada taraf signifikansi 5% dengan df = 44-2= 42 adalah 1,680 dikarenakan thitung > ttabel (1,189 < 1,680) maka Ho diterima Ha ditolak, sedangkan variabel disiplin kerja (X2) thitung sebesar 2,778, sedangkan ttabel pada taraf signifikansi 5% dengan df = 44-2= 42 adalah 1,680 dikarenakan thitung > ttabel (2,778 > 1,680) maka Ho ditolak Ha diterima. Artinya motivasi (X1) dan disiplin kerja (X2) berpengaruh positif terhadap kinerja pegawai Kantor Camat Kecamatan Sanga Desa.
ANALISIS PENGARUH TERJADINYA AUDIT DELAY PADA PERUSAHAAN SARANA DAN PRASARANA YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2019-2021
Authors: AULIA CHANIA , Setiawati Erma 
Published: April 2023

ABSTRAK

Penelitian ini dilakukan untuk menganalis pengaruh Ukuran Perusahaan, Profitabilitas, Solvabilitas, Komite Audit, dan Earning Per Share terhadap Audit Delay Studi kasus Terhadap Perusahaan Sarana dan Prasarana Yang Terdaftar Di Bursa Efek Indonesia Tahun 2019 - 2021. Sampel yang digunakan dalam penelitian ini adalah perusahaan sarana dan prasarana sub sektor real estate, building infrastructure, utilities dan transportation di Bursa Efek Indonesia (BEI) periode tahun 2019 - 2021. Berdasarkan hasil pengujian didapatkan kesimpulan sebagai berikut hasil pengujian secara simultan menunjukan bahwa Ukuran Perusahaan, Profitabilitas, Solvabilitas, Komite Audit, dan Earning Per Share berpengaruh signifikan Terhadap Audit Delay Pada Perusahaan Sarana dan Prasarana Yang Terdaftar Di Bursa Efek Indonesia Tahun 2019 - 2021. Hasil pengujian secara parsial menunjukan bahwa Solvabilitas, berpengaruh negative signifikan Terhadap Audit Delay Pada Perusahaan Sarana dan Prasarana Yang Terdaftar Di Bursa Efek Indonesia Tahun 2019 - 2021. Hasil pengujian secara parsial menunjukan bahwa Komite Audit berpengaruh positif signifikan Terhadap Audit Delay Pada Perusahaan Sarana dan Prasarana Yang Terdaftar Di Bursa Efek Indonesia Tahun 2019 -2021. Hasil pengujian secara parsial menunjukan bahwa Ukuran Perusahaan, Profitabilitas, dan Earning Per Share tidak berpengaruh signifikan Terhadap Audit Delay Pada Perusahaan Sarana dan Prasarana Yang Terdaftar Di Bursa Efek Indonesia Tahun 2019 - 2021.
PENGARUH UKURAN PERUSAHAAN, RETURN ON ASSET (ROA), DEBT TO EQUITY RATIO (DER) DAN CURRENT RATIO (CR) TERHADAP AUDIT DELAY
Authors: Arindi Putra Renaldi , Subiyanto Bambang 
Published: April 2023

Audit Delay yang melewati batas waktu ketentuan POJK Nomor : 14/POJK.04/2022 akan berakibat pada keterlambatan publikasi laporan keuangan. Keterlambatan publikasi laporan keuangan mengindikasikan adanya masalah dalam laporan keuangan perusahaan sehingga memerlukan waktu yang lebih lama untuk menyelesaikan audit. Tujuan dari penelitian ini adalah untuk mendapatkan bukti empiris dan menganalisis pengaruh ukuran perusahaan, return on asset, debt to equity ratio, dan current ratio terhadap audit delay. Variabel audit delay diukur dengan variabel dummy dengan kriteria apakah perusahaan melewati batas pelaporan atau tidak melewati batas Pelaporan Keuangan tahun 2017-2021. Jumlah populasi dalam penelitian ini 142 perusahaan dengan 35 perusahaan yang menjadi sampel penelitian, akhirnya keseluruhan observasi 175. Penelitian ini menggunakan data sekunder yang diperoleh dari bursa efek Indonesia dan situs resmi dari masing-masing perusahaan. Pengambilan data dalam penelitian ini menggunakan teknik purposive sampling. Teknik analisis yang digunakan adalah analisis regresi logistik. Pengolahan data menggunakan aplikasi SPSS 26. Hasil penelitian menunjukan ukuran perusahaan dan return on asset memiliki pengaruh negatif signifikan terhadap audit delay, debt to equity ratio dan current ratio memiliki pengaruh positif signifikan terhadap audit delay,
Kajian KAJIAN MINAT BELI ULANG SECARA ONLINE PADA GENARASI Z DENGAN PERCEIVED RISK, KEPERCAYAAN, DAN GAYA HIDUP SEBAGAI VARIABEL ANTESEDEN
Authors: Asmoro Anjas Kridho , Nuvriasari Audita 
Published: April 2023

This research analyses the effect of perceived risk, trust, and lifestyle towards online repurchase intention on gen z using Shopee as a marketplace. Sampling technique used purposive sampling and 100 respondents in the research sample in total. Hypothesis result of this research is proven that perceived risk has no significant affect towards online repurchase intention. It refers that perceived risk variable isn't affected to online repurchase intention on gen Z. Hence, the opposite of previous statement, trust and lifestyle have positive influenced and significantly towards online repurchase intention. The higher trust that given and the more gen Z's lifestyle fitted with online purchase behavior in Shopee marketplace, would likely increase online repurchase intention. Determination test results show that perceived risk, trust and lifestyle affected to 51,8% online repurchase intention.