bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Platelet-Rich Plasma in Reducing Pain, Pruritis, and Improving Wound Healing of Skin Graft Donor Site
Authors: Ali Sheikh Sarfraz , Ahmad Imran , Khurram Mohammed Fahud , Chaudhury Gautam , Karad Somnath , Tripathi Sudanshu , Sharma Aditi 
Published: December 2022

AbstractBackground Wound healing is a dynamic and complex process. Therefore, no single agent can efficiently mediate all aspects of the wound healing process. Split-thickness graft has become a workhorse of plastic surgery for wound or raw area cover. In this study, we evaluate the effectiveness of autologous platelet-rich plasma (PRP) on the donor site and its effect in pain, purities, and epithelization.Materials and Methods This is a prospective study. A total of 15 patients were included who underwent split skin grafting for burns, trauma, or post-tumor excision raw area. PRP was prepared using standard described procedure. The donor site raw area after harvesting split-thickness graft was measured and the surface area was divided into two equal halves. One half was dressed using PRP and the other half was dressed using paraffin gauze piece only. The dressings were changed weekly for 3 weeks.Observation We found significant reduction in severity of pain and pruritis in the PRP group as compared with control group. Epithelization was faster in the PRP group on day 7 and 14, but the overall healing time was nearly the same by day 21. The side-by-side dressing thus show a definite improvement in the post-split-thickness skin graft wound care and PRP as a good dressing alternative.Conclusion Autologous PRP is very effective adjuvant in management of skin graft donor site. Its role in relieving pain and pruritis over donor site significantly improves patient's discomfort postoperatively. It helps in early and painless wound healing. However, we recommend for larger clinical study for better understanding of the efficacy of this blood product.
A Prospective Multicenter Randomized Controlled Trial to Evaluate the Efficacy of Chitosan Hydrogel Paste in Comparison to Commercial Hydroactive Gel as a Wound Bed Preparation
Authors: Nasir Nur Azida Mohd , Saad Arman Zaharil Mat , Bachok Nor Sa'adah , Rashid Ahmad Hazri Ab , Ujang Zanariah , Noorsal Kartini , Yusof Norimah , Hashim Kamaruddin , Nor Fatimah Mohd , Imran Farrah-Hani , Yusof Nazri Mohd , Sharifudin Mohd Ariff , Halim Ahmad Sukari 
Published: December 2022

abstract
Background This clinical trial aimed to evaluate the clinical efficacy of chitosan derivative hydrogel paste (CDHP) as a wound bed preparation for wounds with cavities.
Methods This study enrolled 287 patients, with 143 patients randomized into the CDHP group (treatment) and 144 patients randomized into the commercial hydroactive gel (CHG) group (control). The granulation tissue, necrotic tissue, patient comfort, clinical signs, symptoms, and patient convenience during the application and removal of the dressing were assessed.
Results The study was completed by 111 and 105 patients from the treatment and control groups, respectively. Both groups showed an increasing mean percentage of wound granulation over time when the initial wound size and comorbidity were adjusted (F(10,198) = 4.61; p < 0.001), but no significant difference was found between the groups (F(1,207) = 0.043; p = 0.953). The adjusted mean percentage of necrotic tissue of both groups showed a significant decrease over time (F(10,235) = 5.65; p <0.001), but no significant differences were found between the groups (F (1,244) = 0.487; p = 0.486).
Conclusion CDHP is equivalent to CHG and is an alternative in wound management and wound bed preparation for wounds with cavities.
Facial Scar Management by Hair Transplant: A Case Report
Authors: Khare Nishant , Kothari Ankit , Ghorawat Aditi Bardia 
Published: December 2022

AbstractFacial scars in hair-bearing areas are a difficult problem to deal with owing to the nature of the scar tissue and the poor survivability of the grafts. A 26-year-old male presented with a scar on the right cheek area. The patient complained of recurrence and widening of scar and resultant facial asymmetry after serial excision in another hospital. The scar was the result of a burn injury sustained 15 years back. The scar was managed by using 2,642 hair grafts harvested from the scalp area. The patient had excellent hair growth at the end of 1 year with a high satisfaction level. There was a visible improvement in the lip deviation. Restoration of hair in the hair-bearing region of the face may be considered a permanent single-stage solution in such patients.
Clinical Phenotype of Respiratory Syncytial Virus Bronchiolitis before and during the Coronavirus Disease 2019 Pandemic
Authors: Rodríguez-Fernández Rosa , González-Martínez Felipe , Perez-Moreno Jimena , González-Sánchez María Isabel , de la Mata Navazo Sara , Toledo del Castillo Blanca , Saavedra Lozano Jesus , Voltas Espinosa Lucia , Manso Perez Sara , Miñarro Berlanga María , Mejias Asuncion , Ramilo Octavio 
Published: December 2022

Objective The main objective of this report was to comprehensively analyze the clinical characteristics of children hospitalized with respiratory syncytial virus (RSV) infections in 2021 during the coronavirus disease 2019 (COVID-19) pandemic and to compare them with those in the five previous RSV seasons. We hypothesized that the clinical and demographic features of children hospitalized with RSV infection in 2021 were different from those hospitalized in previous respiratory seasons.
Study Design In this retrospective observational study, children younger than 2 years hospitalized with RSV bronchiolitis from January 1, 2015, to December 31, 2021, at the Department of Pediatrics of the Hospital Gregorio Marañón, Madrid, Spain, were included. We compared the clinical characteristics of children hospitalized with RSV bronchiolitis in the five seasons before the COVID-19 pandemic and during the subsequent off-seasonal surge of RSV infections.
Results We found a significant reduction in hospitalizations for RSV bronchiolitis during the usual winter epidemic period due to the COVID-19 pandemic. Children hospitalized with RSV infection in 2021, during the COVID-19 pandemic, were older than children hospitalized in the prepandemic period (2015–2020; 4.0 [1.6–9.2] vs. 3 [1.5–6.5] months; p < 0.01). We also found shorter duration of oxygen days during the COVID-19 period compared with previous respiratory seasons (3 [2–5] vs. 4 [2–6] days; p = 0.02).
Conclusion The COVID-19 pandemic modified the RSV seasonality with a significant reduction in RSV hospitalizations during the expected 2020–2021 season and a reappearance of RSV 7 months later than expected. We also found changes in the median age of children with RSV bronchiolitis during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic compared with the prepandemic RSV seasons and shorter duration of oxygen days suggesting a modest reduction in disease severity. We hypothesize that this observation reflects the lack of RSV circulation in the previous months (April 2020-March 2021), with a larger pool of vulnerable infants that had not been previously infected.
Key Points
Difference between Capillary Blood Glucose of Free Flap and the Patient: A Novel Objective Marker of Free Flap Vascular Compromise during Postoperative Monitoring
Authors: Chakraborty Sourabh Shankar , Sahu Ranjit Kumar , Midya Manojit , Malhotra Anjana , Goel Akhil Dhanesh , Pundhir Ashish , Acharya Sudeshna 
Published: December 2022

Abstract
Background Defining cut-off values of flap glucose levels in diagnosing free flap vascular compromise, without taking patients' glucose levels into account, does not hold good in all circumstances, especially in cases of high fluctuations in patients' capillary blood glucose and in diabetic patients. The aim of our study was to establish the role of capillary blood glucose measurements of the flap in relation to patients' fingertip, as an objective tool for postoperative free flap monitoring.
Methods A total of 76 free flaps underwent postoperative monitoring with reference test (clinical parameters) and simultaneously with our index test (difference between capillary blood glucose of free flap and the patient), in non-diabetic and diabetic patients. Patients' demography and flap characteristics were also recorded. An ROC curve was plotted to determine diagnostic accuracy and cut-offs of the index test in diagnosing free flap vascular compromise.
Results Our Index test has a cut-off value of 24.5 mg/dL with 68.75% sensitivity and 93% specificity, with an accuracy of 91.54%.
Conclusion The difference between capillary blood glucose of free flap and the patient is simple, feasible, and inexpensive, and can be done by any health care professional and does not require any specialized facilities or training. It has an excellent diagnostic accuracy to detect impending free flap vascular compromise, especially in non-diabetics. Although in diabetics, this test becomes less accurate. Being an observer-independent objective test, the difference in capillary blood glucose of patient and flap measurement can be used as a highly reliable tool for postoperative free flap monitoring.
The Noninvasive Evaluation for Minimally Invasive Pediatric Epilepsy Surgery (MIPES): A Multimodal Exploration of the Localization-Based Hypothesis
Authors: Mohanty Deepankar , Quach Michael 
Published: December 2022

AbstractMinimally invasive pediatric epilepsy surgery (MIPES) is a rising technique in the management of focal-onset drug-refractory epilepsy. Minimally invasive surgical techniques are based on small, focal interventions (such as parenchymal ablation or localized neuromodulation) leading to elimination of the seizure onset zone or interruption of the larger epileptic network. Precise localization of the seizure onset zone, demarcation of eloquent cortex, and mapping of the network leading to seizure propagation are required to achieve optimal outcomes. The toolbox for presurgical, noninvasive evaluation of focal epilepsy continues to expand rapidly, with a variety of options based on advanced imaging and electrophysiology. In this article, we will examine several of these diagnostic modalities from the standpoint of MIPES and discuss how each can contribute to the development of a localization-based hypothesis for potential surgical targets.
Correlation of Magnetic Resonance Imaging (Neurography) and Electrodiagnostic Study Findings with Intraoperative Findings in Post Traumatic Brachial Plexus Palsy
Authors: Patel Neehar R. , Takwale Anupam B. , Mansukhani K.A , Jaggi Sunila , Thatte Mukund R. 
Published: December 2022

Abstract
Background The majority of brachial plexus injuries (BPIs) are caused by trauma; most commonly due to two-wheeler road accidents. It is important to determine whether the lesion in question is pre-ganglionic or post-ganglionic for purposes of surgical planning and prognosis. Diagnostic testing helps the surgeon to not only decide whether surgical intervention is required, but also in planning the procedure, thereby maximizing the patient's chances of early return to function. The aim of the study was to determine the diagnostic efficacy of electrodiagnostic studies (Edx) and magnetic resonance imaging (MRI) individually, and in unison, in detecting the type and site of BPI by comparison with intraoperative findings (which were used as the reference standard) in patients with posttraumatic BPI.
Methods It is an observational cross-sectional prospective randomized study, wherein 48 patients with BPI underwent a detailed clinical and neurological examination of the upper limb, Edx, MRI neurography and were subsequently operated upon. We assessed a total of 240 roots. The diagnosis of all spinal roots was noted on Edx. MRI was performed to look for root avulsion, pseudomeningocoele, and/or rupture injury. The patients were subsequently operated upon. All roots were traced from infraclavicular level right up to the foramen to ensure continuity of root or note rupture/ avulsion. The findings were tabulated.
Results MRI accurately diagnosed 138 of the 147 injured roots and MRI sensitivity for the detection of BPI was 93.88%, whereas Edx correctly identified 146 out of 147 injured roots and thus, had sensitivity of 99.32%; however, both lacked specificity (18.28 and 20.43%, respectively). With Edx and MRI in unison, sensitivity was 100% which meant that if a given patient with a BPI is subjected to both tests, not a single abnormal root will go unnoticed.
Conclusion Edx and MRI are two highly sensitive investigation modalities whose combined sensitivity is 100% for the detection of a root injury. Therefore, we recommend both tests as they are excellent screening tests.
Epistemology of the side effect: anecdote and evidence in the digital age
Authors: Lentacker Antoine 
Published: December 2022

AbstractThrough the history of rxisk.org, this article explores some of the Web’s effects on the production and circulation of pharmaceutical knowledge. RxISK is an independent website that solicits reports from patients in order to uncover drug-induced harms which clinical trials and national pharmacovigilance schemes fail to identify. The first part of the article locates the origins of the project in the nearly 15-year struggle to obtain recognition and redress for one particular side effect of selective serotonin reuptake inhibitor (SSRI) antidepressants—their ability to trigger violent or suicidal behavior. That struggle, I show, brought to light the ways in which modern evidence-making practices obscure the harms of pharmacological treatment. The second part, based on interviews with the site’s creators, examines how RxISK’s data collection practices seek to convert the Web from a site for the circulation of misinformation into a usable source of new knowledge about drugs. The project’s originality, I argue, lies in its effort to reframe the relation between anecdote and evidence so as to liberate the patient’s voice from the burden of representativeness. Within this reframed epistemology, the project is also freed from the imperative of large-scale data extraction that increasingly dominates the economy of digital health.
Post-2018 Ethiopia: state fragility, failure, or collapse?
Authors: Bayeh Endalcachew 
Published: December 2022

AbstractOwing to the multifaceted problems in which Ethiopia has been embroiled, such as war, displacement, and humanitarian crisis, writers arbitrarily use terms such as “state fragility,” “state failure,” and “state collapse” to represent the situation. This paper intends to determine what these concepts mean and to analyze whether post-2018 Ethiopia can be characterized by state fragility, failure, or collapse. To this end, I use a qualitative approach in which I gathered relevant data mainly from secondary sources. Accordingly, the study shows that state fragility, state failure, and state collapse are concepts related to the capacity and ability of the state to exercise a monopoly on the legitimate use of violence and perform its basic functions well. State fragility occurs if the state fails to exercise a monopoly on violence, protect its citizens, provide adequate public services, and maintain legitimacy. State failure, on the other hand, occurs when these problems become more critical, challenging the state’s existence. Finally, state collapse occurs when a state is completely disintegrated, leaving an authority vacuum. Based on this understanding, my findings indicate that Ethiopia is currently in a fragile condition and has started the process of descent into state failure. This apparent weakness of the state has devastating implications for the region, given the country’s previous stabilizing role, large population, and shared border with other regional states, among others. I argue that unless the necessary actions are taken, the situation might become worse and further destabilize an already volatile region.
Designing and analyzing multi-coil multi-layers for wireless power transmission in stent restenosis coronary artery
Authors: Alghrairi Mokhalad , Sulaiman Nasri , Mutashar Saad , Wan Hasan Wan Zuha , Jaafar Haslina , Algriree Waleed 
Published: December 2022

Wireless power transfer technology features shorter power transmission distances in biomedical applications. This is a result of the small size of the implanted coils, biocompatible material conductivity, and the large distances between the receiving and transmitting coils. There have been numerous attempts to improve the power transfer efficiency across longer distances. Multiple coils, including 2-, 3-, 4-, and multi-layered coils, were previously considered. This study proposes a novel approach to achieve higher power transmission efficiency by integrating a single coil on the receiving side and three asymmetric coils on the transmitter side. As such, it delivers power to the sensor implanted within the coronary artery that monitors the blood pressure while introducing a uniquely shaped stent. The efficiency of power transmitted to the stent in its dual implanted forms, helical and zigzag helical, was examined as well, with the wireless power transmission system thereby analyzed at the 27 MHz Industrial Scientific Medical band operating frequency. For the four-coil technique, the power transmission efficiency at a distance of 25 mm between the receiver and transmitter sides by using biological human tissue as a medium between the transmission coils and the receiver stent can reach 56.42%, whereas other approaches show lower efficiencies: the three-coil method’s efficiency is 32.88%, the double-layer parallel method’s efficiency is 27.75%, the two-coil method’s efficiency is 24.76%, the triple-layer parallel method’s efficiency is 17.31%, the double-layer series method’s efficiency is 0.501%, and the triple-layer series method’s transmission efficiency is 0.092%. In addition, the suggested approach is demonstrated to be more efficient than prior designs with regard to the size of the implanted coils, which represent stents.
Enthalpies of formation for Criegee intermediates: A correlation energy convergence study
Authors: Begley James M. , Aroeira Gustavo J. R. , Turney Justin M. , Douberly Gary E. , Schaefer Henry F. 
Published: December 2022

Criegee intermediates, formed from the ozonolysis of alkenes, are known to have a role in atmospheric chemistry, including the modulation of the oxidizing capacity of the troposphere. Although studies have been conducted since their discovery, the synthesis of these species in the laboratory has ushered in a new wave of investigations of these structures, both theoretically and experimentally. In some of these theoretical studies, high-order corrections for correlation energy are included to account for the mid multi-reference character found in these systems. Many of these studies include a focus on kinetics; therefore, the calculated energies should be accurate (&lt;1 kcal/mol in error). In this research, we compute the enthalpies of formation for a small set of Criegee intermediates, including higher-order coupled cluster corrections for correlation energy up to coupled cluster with perturbative quintuple excitations. The enthalpies of formation for formaldehyde oxide, anti-acetaldehyde oxide, syn-acetaldehyde oxide, and acetone oxide are presented at 0 K as 26.5, 15.6, 12.2, and 0.1 kcal mol−1, respectively. Additionally, we do not recommend the coupled cluster with perturbative quadruple excitations [CCSDT(Q)] energy correction, as it is approximately twice as large as that of the coupled cluster with full quadruple excitations (CCSDTQ). Half of the CCSDT(Q) energy correction may be included as a reliable, cost-effective estimation of CCSDTQ energies for Criegee intermediates.
Strongly coupled intermediate electronic states in one-color two-photon single valence ionization of O2
Authors: Larsen Kirk A. , Bello Roger Y. , Lucchese Robert R. , McCurdy C. William , Slaughter Daniel S. , Weber Thorsten 
Published: December 2022

We present an experimental and theoretical energy- and angle-resolved investigation on the non-dissociative photoionization dynamics of near-resonant, one-color, two-photon, single valence ionization of neutral O2 molecules. Using 9.3 eV femtosecond pulses produced via high harmonic generation and a 3-D momentum imaging spectrometer, we detect the photoelectrons and O2+ cations produced from one-color, two-photon ionization in coincidence. The measured and calculated photoelectron angular distributions show agreement, which indicates that a superposition of two intermediate electronic states is dominantly involved and that wavepacket motion on those near-resonantly populated intermediate states does not play a significant role in the measured two-photon ionization dynamics. Here, we find greater utility in the diabatic representation compared to the adiabatic representation, where invoking a single valence-character diabat is sufficient to describe the underlying two-photon ionization mechanism.
Update of the BIPM comparison BIPM.RI(II)-K1.Y-88 of activity measurements of the radionuclide 88Y to include the 2016 result of the LNE-LNHB (France) and the 2019 result of the BEV (Austria)
Authors: Michotte C , Courte S , Coulon R , Nonis M , Judge S , Ratel G , Maringer F J , Brettner-Messler R , Fréchou C , Bobin C 
Published: December 2022

Main text
Since 1976, 15 laboratories have submitted 39 samples of 88Y to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Y-88. Recently, the LNE-LNHB (France) and the BEV (Austria) participated in the comparison and the key comparison reference value (KCRV) has been updated. The degrees of equivalence between each equivalent activity measured in the SIR and the updated KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Properties of the non-Hermitian SSH model: role of

symmetry
Authors: Halder Dipendu , Ganguly Sudin , Basu Saurabh 
Published: December 2022

Abstract
The present work addresses the distinction between the topological properties of

symmetric and non-

symmetric scenarios for the non-Hermitian Su–Schrieffer–Heeger model. The non-

symmetric case is represented by non-reciprocity in both the inter- and the intra-cell hopping amplitudes, while the one with

symmetry is modeled by a complex on-site staggered potential. In particular, we study the loci of the exceptional points, the winding numbers, band structures, and explore the breakdown of bulk-boundary correspondence (BBC). We further study the interplay of the dimerization strengths on the observables for these cases. The non-

symmetric case denotes a more familiar situation, where the winding number abruptly changes by half-integer through tuning of the non-reciprocity parameters, and demonstrates a complete breakdown of BBC, thereby showing non-Hermitian skin effect. The topological nature of the

symmetric case appears to follow closely to its Hermitian analogue, except that it shows unbroken (broken) regions with complex (purely real) energy spectra, while another variant of the winding number exhibits a continuous behavior as a function of the strength of the potential, while the conventional BBC is preserved.