bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equation discovery using mode extraction via singular value decomposition
Authors: Suzuki Takuya 
Published: December 2022

AbstractMany studies have been conducted to elucidate unknown input/output systems based on measured data obtained from experiments and observations. Specifically, neural networks, which have been significantly developed in recent years, can be used for equation discovery. However, the identified networks are considerably large and difficult to understand. Many studies have been conducted on mathematical expressions that are easy to understand; however, there is a paucity of studies on methods to determine a simple equation by eliminating unnecessary terms. In this study, we propose a novel method for identifying unknown equations using mode extraction via singular value decomposition. In this method, the “process of improving the precision of an equation” and the “process of deleting unnecessary terms” are alternately iterated based on singular value decomposition. We confirm the applicability of the proposed method via a sample problem on cantilever deflection. Therefore, the proposed method can accurately determine an equation of an input/output system composed of only essential terms (i.e., excluding unnecessary terms) from training data.
ePURE_JSBML: A Tool for Constructing a Deterministic Model of a Reconstituted Escherichia coli Protein Translation System with a User‐Specified Nucleic Acid Sequence
Authors: Shimizu Yoshihiro , Tanimura Naoki , Matsuura Tomoaki 
Published: December 2022

AbstractA protein synthesis system is one of the most important and complex biological networks, which translates DNA‐encoded information into specific functions. Here, ePURE_JSBML, a tool for constructing biologically relevant large‐scale and detailed computational models based on a reconstituted cell‐free protein synthesis system, is presented; the user can specify the mRNA sequence, initial component concentration, and decoding rule. Model construction is based on Systems Biology Markup Language (SBML) using JSBML, a pure Java programming library. The tool generates simulation files, executable with Matlab, that enable a variety of simulation experiments including the synthesis of proteins of a few hundred residues.
Bimetallic‐Based Electrocatalysts for Oxygen Evolution Reaction
Authors: Jiang Jun , Zhou Xiao‐Li , Lv Hua‐Gang , Yu Han‐Qing , Yu Yan 
Published: December 2022

AbstractThe electrochemical oxygen evolution reaction (OER) is a core electrode reaction for the renewable production of high‐purity hydrogen, carbon‐based fuel, synthetic ammonia, etc. However, the sluggish kinetics of the OER result in a high overpotential and limit the widespread application of OER‐based technologies. Recent studies have shown that bimetallic‐based materials with the synergism of different metal components to regulate the adsorption and dissociation energy of intermediates are promising OER electrocatalyst candidates with a lower cost and energy consumption. In the past two decades, tremendous efforts have been devoted to developing OER applications of bimetallic‐based materials with a focus on compositions, phase, structure, etc., to highlight the synergism of different metal components. However, there is a lack of critical thinking and organized analysis of OER applications with bimetallic‐based materials. This review critically discusses the challenges of developing bimetallic‐based OER materials, summarizes the current optimization strategies to enhance both activity and stability, and highlights the state‐of‐the‐art electrocatalysts for OER. The relationship between the componential/structural features of bimetallic‐based materials and their electrocatalytic properties is presented to form comprehensive electronic and geometric modifications based on thorough analysis of the reported works and discuss future efforts to realize sustainable bimetallic‐based OER applications.
Implanting of Single Zinc Sites into 2D Metal–Organic Framework Nanozymes for Boosted Antibiofilm Therapy
Authors: Wang Xiaoyu , Hu Wenchao , Xia Xing‐Hua , Wang Chen 
Published: December 2022

AbstractDesign of nanozymes with catalytic active sites at atomic‐scale not only improves the atomic utilization, but also provides a well‐defined coordination structure for nanozymes’ catalytic mechanism research. Herein, a surfactant‐assisted method is reported for preparing 2D metal–organic frameworks based single zinc sites nanozyme (SZN‐MOFs) through assembling preformed Zn single‐atom coordinated porphyrin precursors into ultrathin MOF nanosheets. The Zn atom loading weight ratio in SZN‐MOFs is up to 4.6 wt.%. The SZN‐MOFs exhibit extraordinary peroxidase‐like activity, which can effectively catalyze H2O2 into hydroxyl radicals. The catalytical mechanism is elucidated and the origin of the high peroxidase‐like activity of SZN‐MOFs is rationalized using density functional theory calculations. Finally, it is demonstrated that the SZN‐MOFs present great promises for in vitro and in vivo antibiofilm activity under a low concentration of H2O2. This study not only develops a surfactant‐assisted method for fabricating MOF‐based single sites nanozyme, but also manifests the applications in the field of antibiofilm therapy.
Large‐Area Blade‐Coated Deep‐Blue Polymer Light‐Emitting Diodes with a Narrowband and Uniform Emission
Authors: Wang Shengjie , Sun Lili , Zheng Yingying , Zhang Yahui , Yu Ningning , Yang Jinghao , Li Mengyuan , Chen Wenyu , He Liangliang , Liu Bin , Ni Mingjian , Liu Heyuan , Xu Man , Bai Lubing , Lin Jinyi , Huang Wei 
Published: December 2022

AbstractLarge‐area polymer light‐emitting diodes (PLEDs) manufactured by printing are required for flat‐panel lighting and displays. Nevertheless, it remains challenging to fabricate large‐area and stable deep‐blue PLEDs with narrowband emission due to the difficulties in precisely tuning film uniformity and obtaining single‐exciton emission. Herein, efficient and stable large‐area deep‐blue PLEDs with narrowband emission are prepared from encapsulated polydiarylfluorene. Encapsulated polydiarylfluorenes presented an efficient and stable deep‐blue emission (peak: 439 nm; full width at half maximum (FWHM): 39 nm) in the solid state due to their single‐chain emission behavior without inter‐backbone chain aggregation. Large‐area uniform blade‐coated films (16 cm2) are also fabricated with excellent smoothness and morphology. Benefitting from efficient emission and excellent printed capacity, the blade‐coated PLEDs with a device area of 9 mm2 realized uniform deep‐blue emission (FWHM: 38 nm; CIE: 0.153, 0.067), with a corresponding maximum external quantum efficiency and the brightness comparable to those of devices based on spin‐coated films. Finally, considering the essential role of deep‐blue LEDs, a preliminary patterned PLED array with a pixel size of 800 × 1000 µm2 and a monochrome display is fabricated, highlighting potential full‐color display applications.
Regulating Zn Ion Desolvation and Deposition Chemistry Toward Durable and Fast Rechargeable Zn Metal Batteries
Authors: Zhou Yuhang , Li Guoyu , Feng Saifei , Qin Hongyu , Wang Qiancheng , Shen Fang , Liu Penggao , Huang Yanping , He Huibing 
Published: December 2022

AbstractThe high Zn ion desolvation energy, sluggish Zn deposition kinetics, and top Zn plating pattern are the key challenges toward practical Zn anodes. Herein, these key issues are addressed by introducing zinc pyrovanadate (ZVO) as a solid zinc‐ion conductor interface to induce smooth and fast Zn deposition underneath the layer. Electrochemical studies, computational analysis, and in situ observations reveal the boosted desolvation and deposition kinetics, and uniformity by ZVO interface. In addition, the anti‐corrosion ability of Zn anodes is improved, resulting in high Zn stripping/plating reversibility. Consequently, the ZVO layer renders fast rechargeability and durable life in both Zn symmetric cells (1050 h at 10 mA cm−2, 1 mAh cm−2) and Zn/V2O5 batteries (79.1% capacity retention after 1000 cycles at 2 A g−1) with low electrode polarization. This work provides insights into the design of solid zinc‐ion conductor interface to enhance the interface stability and kinetics of Zn metal anodes.
Essential updates 2020/2021: Advancing precision medicine for comprehensive rectal cancer treatment
Authors: Takemasa Ichiro , Hamabe Atsushi , Miyo Masaaki , Akizuki Emi , Okuya Koichi 
Published: December 2022

AbstractIn the paradigm shift related to rectal cancer treatment, we have to understand a variety of new emerging topics to provide appropriate treatment for individual patients as precision medicine. However, information on surgery, genomic medicine, and pharmacotherapy is highly specialized and subdivided, creating a barrier to achieving thorough knowledge. In this review, we summarize the perspective for rectal cancer treatment and management from the current standard‐of‐care to the latest findings to help optimize treatment strategy.
A typical variant in TCF4 exon 18 is not associated with Pitt–Hopkins syndrome but with a familial case of mild and nonspecific neurodevelopmental disorder
Authors: Aldeeri Abdulrahman A. , Abu‐El‐Haija Aya 
Published: December 2022

AbstractTCF4 gene encodes a class I helix–loop–helix transcription factor critical for the developing brain. Common polymorphisms in TCF4 and disruptive variants in the proximal region of the gene have been linked to relatively mild neuropsychiatric or neurodevelopmental disorders. In contrast, variants impacting distal exons are associated with Pitt–Hopkins syndrome (PTHS), a severe autosomal dominant condition characterized by profound intellectual disability, developmental delay, limited or absent speech, distinctive facies, and disordered breathing. Although phenotypic variability has been observed in PTHS, intellectual impairment and significant speech and motor delays are invariably present. In contrast to the typical de novo variants causing TCF4‐related disorder and PTHS, we report a familial form of TCF4‐related disorder where the missense variant arose de novo in the father and was inherited by two of his children. Although this family's variant's position in exon 18 predicted a typical PTHS phenotype, none of the affected individuals met the clinical diagnostic criteria for PTHS suggested by Zollino et al. in the first international consensus statement (as in the study by Zollino et al. in 2019). Rather, the three affected family members exhibited remarkably variable and milder phenotypes than would have been predicted from the position of their TCF4 variant. Thus, the clinical spectrum of PTHS‐associated TCF4 variants may be broader than previously reported.
I2‐Catalyzed Cycloisomerization of Ynamides: Chemoselective and Divergent Access to Indole Derivatives
Authors: Zhu Bo‐Han , Ye Sheng‐Bing , Nie Min‐Ling , Xie Zhong‐Yang , Wang Yi‐Bo , Qian Peng‐Cheng , Sun Qing , Ye Long‐Wu , Li Long 
Published: December 2022

AbstractHerein, an I2‐catalyzed unprecedented cycloisomerization of ynamides is developed, furnishing various functionalized bis(indole) derivatives in generally good to excellent yields with wide substrate scope and excellent atom‐economy. This protocol not only represents the first molecular‐iodine‐catalyzed tandem complex alkyne cycloisomerizations, but also constitutes the first chemoselective cycloisomerization of tryptamine‐ynamides involving distinctively different C(sp3)−C(sp3) bond cleavage and rearrangement. Moreover, chiral tetrahydropyridine frameworks containing two stereocenters are obtained with moderate to excellent diastereoselectivities and excellent enantioselectivities. Meanwhile, cycloisomerization and aromatization of ynamides produce pyrrolyl indoles with high efficiency enabled by I2. Additionally, control experiments and theoretical calculations reveal that this reaction probably undergoes a tandem 5‐exo‐dig cyclization/rearrangement process.
Am Rande des Bekannten: Extrem elektronenreiche (Di)carboranylphosphane
Authors: Schulz Jan , Clauss Reike , Kazimir Aleksandr , Holzknecht Sieglinde , Hey‐Hawkins Evamarie 
Published: December 2022

AbstractDie Synthese der ersten B9‐verbundenen Carboranylphosphane (B9‐Phos) mit zwei Carboranyleinheiten sowie der Zugang zu B9‐Phos‐Liganden mit sperrigen elektronen‐schiebenden Substituenten, die bisher als unerreichbar galten, werden vorgestellt. Die elektrochemischen Eigenschaften der B9‐Phos‐Liganden wurden untersucht und die Fähigkeit der Mesityl‐Derivate, stabilisierte Phosphoniumylradikalkationen zu bilden, wurde gezeigt. Die B9‐Phos‐Liganden weisen einen extrem elektronenschiebenden Charakter auf, der den von Alkylphosphanen und allgemein verwendeten N‐heterocyclischen Carbenen übertrifft. Dies wird durch ihre sehr kleinen elektronischen Tolman‐Parameter (TEP) sowie durch extrem niedrige P−Se‐Kopplungskonstanten belegt. Kegelwinkel und verdeckten Volumina belegen die hohe sterische Hinderung, die von den (Di)carboranylphosphanen ausgeht. Die Dicarboranylphosphan‐AuI‐Komplexe zeigen im Vergleich zu den Monocarboranylphosphan‐Analoga eine bessere katalytische Leistung bei der Hydroaminierung von Alkinen.
Guidelines in Practice: Patient Information Management
Authors: Williams Katherine 
Published: December 2022

ABSTRACTPatient information management can involve paper and electronic documentation. Because the patient's health care record (HCR) is a legal document, it must provide an accurate representation of care. The record contains protected health information and must be secure. In addition, the documentation must adhere to local, state, and federal regulations and facility policies; it also may incorporate recommendations from national professional guidelines. The AORN “Guideline for patient information management” was recently updated and provides evidence‐based best practices for comprehensive perioperative documentation that aligns with the nursing workflow. This article includes an overview of patient information management and discusses recommendations for health information technology, the patient HCR, perioperative record design, documentation and nursing workflow, informed consent documentation, order documentation, modifying patient HCRs, education, policies and procedures, and quality. Perioperative nurses should review the guideline in its entirety and apply the recommendations for patient information management as applicable to their individual roles.
A Nomogram for Predicting Unplanned Intraoperative Hypothermia in Patients With Colorectal Cancer Undergoing Laparoscopic Colorectal Procedures
Authors: Yan Lupei , Tan Jingxing , Chen Hao , Xiao Han , Zhang Yi , Yao Qin , Li Yuerong 
Published: December 2022

ABSTRACTUnplanned intraoperative hypothermia is a complication that can lead to a variety of negative outcomes, such as cardiovascular events. We aimed to develop and validate an intraoperative hypothermia risk prediction nomogram for patients with colorectal cancer undergoing laparoscopic colorectal procedures. We conducted a prospective cohort study with 1,091 patients (ie, 765 in the training cohort, 326 in the validation cohort) from October 2020 to November 2021. We included six predictors in the nomogram model: body mass index, diabetes diagnosis, ambient temperature, ambient humidity, duration of surgery, and use of a forced‐air warmer. The model performed well, and the area under the curve was 0.855. These results, together with an external validation value, mean that health care professionals can use the nomogram to calculate the intraoperative hypothermia risk for patients undergoing laparoscopic colorectal procedures and make clinical decisions based on the results.
Surgical Technologist Apprentice Program: An Innovative Approach to Improve Staffing
Authors: Shields Lisa B.E. , Pate Andrea M. , Young Matt W. , Flanders Kimberly 
Published: December 2022

ABSTRACTAlong with surgeons, anesthesia professionals, and RN circulators, surgical technologists are essential members of the perioperative team. Despite a partnership with a local community college that offered a surgical technologist degree program, Norton Healthcare in Louisville, Kentucky, continued to experience a shortage of surgical technologists. To meet demands, the clinical educators at the facility developed an in‐house Surgical Technologist Apprentice Program (STAP). The STAP consists of six weeks of didactic learning and hands‐on training in an OR simulation laboratory, followed by a six‐month preceptorship in the OR. This program has proven invaluable, particularly as the COVID‐19 pandemic increased the need for personnel who are not only skilled in the OR but also can provide essential frontline patient care when needed. Together, the STAP and the college partnership offer a career‐building opportunity for those in entry‐level positions who may not otherwise be able to afford to train for this specialized role.
Electrochemical sensor based on carbon material derived from Physalis alkekengi L. husks for the analysis of ascorbic acid
Authors: Jin Biao , Liu Shanshan , Jin Dongri 
Published: December 2022

AbstractThe design of electrode materials for sensitive electrochemical sensors is important for the rapid detection of ascorbic acid. Using Physalis alkekengi L. husks (PaLH) as the carbon precursor, PaLH‐derived carbon materials (PCM) were prepared by high temperature carbonization, and hierarchical porous carbon materials (KPCM) were prepared by KOH activation. The carbon materials were characterized by scanning electron microscopy, X‐ray diffraction, and isothermal nitrogen adsorption and desorption. KPCM had a larger specific surface area (1345.45 m2 g−1) and more micro/mesopores than PCM without KOH activation. Two types of carbon materials, PCM and KPCM, were used as electrode modifiers, and the electrochemical properties of KPCM/GCE and PCM/GCE (GCE = glassy carbon electrode) were investigated. KPCM/GCE had a higher electron‐transfer rate, higher electrochemically active area, smaller charge‐transfer resistance, wider potential window, and higher catalytic activity for ascorbic acid detection. An ascorbic acid electrochemical sensing platform constructed with KPCM/GCE showed high sensitivity (334.03 μA mM−1 cm−2 and 134.52 μA mM−1 cm−2) and a low detection limit (0.92 μM) (S/N = 3) in the linear range of 0.005–1.6 mM. This method was applied to the analysis and determination of ascorbic acid in chewable vitamin C tablets.
Morphological specialization to nectarivory in Phyllostomus discolor (Wagner, 1843) (Chiroptera: Phyllostomidae)
Authors: Quinche Laura L. , Santana Sharlene E. , Rico‐Guevara Alejandro 
Published: December 2022

AbstractDedicated nectarivory is a derived feeding habit that requires specialized cranial and soft‐tissue morphologies to extract nectar from flowers. Nectarivory has evolved many times in terrestrial vertebrates, and in four bat families (Pteropodidae, Phyllostomidae, Vespertilionidae, and Mystacinidae). Within phyllostomids, specializations to nectarivory have been well documented in two subfamilies, Glossophaginae and Lonchophyllinae. However, nectarivory has also evolved independently in the genus Phyllostomus (subfamily Phyllostominae). Since Phyllostomus species have an omnivorous diet with a high consumption of nectar, they can be used to explore the basic morphological modifications linked to evolving a nectarivorous habit. Here, we focused on describing and comparing the morphological features potentially associated with nectarivory in Phyllostomus discolor. We present the first detailed tongue and palate morphological descriptions for P. discolor and perform skull morphometric analysis including 10 species. We found hair‐like papillae on the tongue of P. discolor, a convergent feature with Glossophaginae and nectarivorous Pteropodids; these papillae likely confer an advantage when feeding on nectar. P. discolor does not show skull morphological features characteristic of nectarivorous bats, such as a long and narrow snout. We pose that the consumption of a variety of food, such as hard insects and fruits, and the large size of P. discolor relative to specialized nectarivores may create trade‐offs against morphological specialization of the skull towards nectarivory. In contrast, a long and mobile tongue with hair‐like papillae may be an evolutionary solution for nectar extraction that does not have a major impact on this species' ability to feed on other resources.
Pronephros and mesonephros characterization during the embryonic development of the giant South American river turtle, Podocnemis expansa (Podocnemididae: Testudines)
Authors: Magalhães Marcela dos Santos , Dias Lucas Castanhola , Oliveira Moacir Franco de , Sebben Antônio , Moura Carlos Eduardo B. de 
Published: December 2022

AbstractThis study aimed to describe pronephros and mesonephros morphology during the embryonic development of Podocnemis expansa. Eggs were collected on an artificial beach at Balbina, Amazonas, Brazil, during the entire incubation period (mean of 59 days). The kidney‐gonad complex was processed using light microscopy and the mesonephros using transmission electron microscopy. The pronephros was present for the first time on stage 4, composed of external glomeruli devoid of a capsule, protruding into the coelomic cavity, and internally composed of a capillary network. The pronephros degenerated after development stage 15. The first sign of the appearance of the mesonephros occurred around stage 8, indicated by the early formation of renal corpuscles. The mesonephros comprised an renal corpuscles, neck segment, proximal tubule, intermediate segment, distal tubule, collector tubule, and collector duct. Ultrastructural analysis of the mesonephros brush border was done in the proximal tubule, and the presence of cells with structural characters indicative of secretory activity was detected in the juxtatubular region. Renal corpuscles and proximal tubules were the main components that underwent morphological alterations during mesonephros degeneration. The pronephros is a transient kidney, and the mesonephros became the functional embryonic kidney in P. expansa. Mesonephros degeneration occurs in the cranial‐caudal direction, and histologically, the degeneration is identified by changes in the morphology of the renal corpuscle and proximal tubule. However, the mesonephros is still present after hatching.
Rosa gallica and its active compound, cyanidin‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway
Authors: Seo Ji‐Won , Jo Seongin , Jung Young Sung , Mijan Mohammad‐Al , Cha Joy , Hong Seungpyo , Byun Sanguine , Lim Tae‐Gyu 
Published: December 2022

AbstractRosa gallica has been previously reported to display anti‐inflammatory, anti‐oxidative, and anti‐skin wrinkle activities. However, the effect of Rosa gallica on skin hydration and its active components are largely unknown. Herein, we aimed to investigate the skin hydration effect of rose petal extract (RPE) in humans and elucidate the underlying molecular mechanism. A double‐blinded clinical study was performed to investigate the effect of RPE on skin hydration. Stratum corneum moisture analysis demonstrated that RPE treatment significantly improved hydration levels in human skin. Furthermore, HAS2 and hyaluronic acid levels were notably increased by RPE in keratinocytes and 3D human skin equivalent model. By comparing the modulatory effect on HAS2 expression, cyanidin‐3,5‐O‐diglucoside (CDG) was identified as the most potent compound in RPE likely responsible for skin hydration. The kinase activity of GLK, an upstream regulator of MAPK signaling, was increased by CDG in a dose‐dependent manner. Importantly, silencing GLK reversed CDG‐mediated HAS2 upregulation, further supporting the involvement of GLK in the CDG‐mediated effects. Binding of CDG to GLK was confirmed by pull‐down assay and computer modeling. These findings suggest that RPE and its active component CDG increases skin hydration by upregulating HAS2 expression through modulating the GLK‐MAP2K‐MAPK signaling pathway.