bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis of effects of yoga exercise intervention on sleep quality in breast cancer patients
Authors: Zhu Jingzhi , Chen Xiaojuan , Zhen Xinxian , Zheng Huan , Chen Hong , Chen Huimin , Liao Huizhao , Zhu Jinru , Wang Chaoyu , Zheng Zhenzhen , Chen Riken , Wang Yang 
Published: June 2023

ObjectiveThis study seeks to systematically evaluate and test the effects of yoga exercise intervention programs on sleep quality in breast cancer patients in order to suggest more optimized exercise programs.MethodComputer searches of the PubMed, Embase, Cochrane Library, Web of Science and CINAHL databases are conducted from the date of their inception to June 8th, 2022 to collect randomized controlled trials on the effects of yoga exercise intervention on sleep quality in breast cancer patients. Two investigators independently carry out the inclusion and exclusion criteria literature screening, data extraction and methodological quality assessment of the included literature by applying the Cochrane risk of bias tool. Subgroup analysis is performed using RevMan 5.4.1 software, and the six moderating variables of intervention format, intervention type, weekly intervention frequency, total intervention duration, single intervention duration and intervention evaluation at different time points are set for the 782 subjects of the 12 included publications.ResultsTwelve randomized controlled trials with a total sample size of 782 subjects are included, including 393 subjects in the experimental group and 389 subjects in the control group. The meta-analysis shows that yoga exercise intervention is effective in improving sleep quality in breast cancer patients [SMD = -0.40, 95% CI: (-0.71, -0.09), P = 0.01]; yoga exercise intervention focusing on positive meditation [SMD = -0.55, 95% CI: (-1.08, -0.03), P = 0.04] is effective in improving sleep; yoga exercise intervention two or three times a week is effective in improving sleep quality [SMD = -0.69, 95% CI: (-1.19, -0.19), P = 0.007]; yoga exercise intervention for 6–8 weeks significantly improves sleep quality [SMD = -0.86, 95% CI: (-1.65, -0.08), P =0.03]; and evaluation immediately after the end of intervention improves sleep outcomes [SMD = -0.17, 95% CI: (-0.33, 0.00), P = 0.05], while differences in sleep quality improvement are not statistically significant for the remaining subgroup outcomes (P &gt; 0.05).ConclusionThe available evidence suggests that yoga exercise intervention has good effects on improving sleep quality in breast cancer patients. Positive meditation intervention type, intervention frequency of two or three times per week, total intervention duration of 6–8 weeks and evaluation immediately after the end of intervention are shown to be effective in improving sleep quality.
CTSL, a prognostic marker of breast cancer, that promotes proliferation, migration, and invasion in cells in triple-negative breast cancer
Authors: Zhang Lianmei , Zhao Yang , Yang Jing , Zhu Yaning , Li Ting , Liu Xiaoyan , Zhang Pengfei , Cheng Jingliang , Sun Suan , Wei Chunli , Fu Junjiang 
Published: June 2023

IntroductionIn the world, the incidence of breast cancer has surpassed that of lung cancer, and it has become the first malignant tumor among women. Triple-negative breast cancer (TNBC) shows an extremely heterogeneous malignancy toward high recurrence, metastasis, and mortality, but there is a lack of effective targeted therapy. It is urgent to develop novel molecular targets in the occurrence and therapeutics for TNBC, and novel therapeutic strategies to block the recurrence and metastasis of TNBC.MethodsIn this study, CTSL (cathepsin L) expression in tissues and adjacent tissues of TNBC patients was monitored by immunohistochemistry and western blots. The correlations between CTSL expressions and clinicopathological characteristics in the patient tissues for TNBC were analyzed. Cell proliferation, migration, and invasion assay were also performed when over-expressed or knocked-down CTSL.ResultsWe found that the level of CTSL in TNBC is significantly higher than that in the matched adjacent tissues, and associated with differentiated degree, TNM Stage, tumor size, and lymph node metastatic status in TNBC patients. The high level of CTSL was correlated with a short RFS (p&lt;0.001), OS (p&lt;0.001), DMFS (p&lt;0.001), PPS (p= 0.0025) in breast cancer from online databases; while in breast cancer with lymph node-positive, high level of CTSL was correlated with a short DMFS (p&lt;0.001) and RFS (p&lt;0.001). Moreover, in vitro experiments showed that CTSL overexpression promotes the abilities for proliferation, migration, and invasion in MCF-7 and MDA-MB-231 cell lines, while knocking-down CTSL decreases its characteristics in MDA-MB-231 cell lines.ConclusionCTSL might involve into the regulation of the proliferation, invasion, and metastasis of TNBC. Thus, CTSL would be a novel, potential therapeutic, and prognostic target of TNBC.
Radiation-induced lung injury after breast cancer treatment: incidence in the CANTO-RT cohort and associated clinical and dosimetric risk factors
Authors: Gueiderikh Anna , Sarrade Thomas , Kirova Youlia , De La Lande Brigitte , De Vathaire Florent , Auzac Guillaume , Martin Anne Laure , Everhard Sibille , Meillan Nicolas , Bourgier Celine , Benyoucef Ahmed , Lacornerie Thomas , Pasquier David , Racadot Séverine , Moignier Alexandra , Paris François , André Fabrice , Deutsch Eric , Duchemann Boris , Allodji Rodrigue Setcheou , Rivera Sofia 
Published: June 2023

PurposeRadiation-induced lung injury (RILI) is strongly associated with various clinical conditions and dosimetric parameters. Former studies have led to reducing radiotherapy (RT) doses to the lung and have favored the discontinuation of tamoxifen during RT. However, the monocentric design and variability of dosimetric parameters chosen have limited further improvement. The aim of our study was to assess the incidence of RILI in current practice and to determine clinical and dosimetric risk factors associated with RILI occurrence.Material and methodsData from 3 out of the 10 top recruiting centers in CANTO-RT, a subset of the CANTO prospective longitudinal cohort (NCT01993498), were retrospectively analyzed for RILI occurrence. This cohort, which recruited invasive cT0-3 cN0-3 M0 breast cancer patients from 2012 to 2018, prospectively recorded the occurrence of adverse events by questionnaires and medical visits at the end of, and up to 60 months after treatment. RILI adverse events were defined in all patients by the association of clinical symptoms and compatible medical imaging.ResultsRILI was found in 38/1565 (2.4%) patients. Grade II RILI represented 15/38 events (39%) and grade III or IV 2/38 events (6%). There were no grade V events. The most frequently used technique for treatment was 3D conformational RT (96%). In univariable analyses, we confirmed the association of RILI occurrence with pulmonary medical history, absence of cardiovascular disease medical history, high pT and pN, chemotherapy use, nodal RT. All dosimetric parameters were highly correlated and had close predictive value. In the multivariable analysis adjusted for chemotherapy use and nodal involvement, pulmonary medical history (OR=3.05, p&lt;0.01) and high V30 Gy (OR=1.06, p=0.04) remained statistically significant risk factors for RILI occurrence. V30 Gy &gt;15% was significantly associated with RILI occurrence in a multivariable analysis (OR=3.07, p=0.03).ConclusionOur study confirms the pulmonary safety of breast 3D RT in CANTO-RT. Further analyses with modern radiation therapy techniques such as IMRT are needed. Our results argue in favor of a dose constraint to the ipsilateral lung using V30 Gy not exceeding 15%, especially in patients presenting pulmonary medical history. Pulmonary disease records should be taken into account for RT planning.
Risk factors associated with cesarean section and adverse fetal outcomes in intrahepatic cholestasis of pregnancy
Authors: Kong Chengcai , Zhu Zonghao , Mei Fenglin 
Published: June 2023

BackgroundTo determine the risk factors for cesarean section (CS) and adverse fetal outcomes (AFOs) in patients with intrahepatic cholestasis of pregnancy (ICP) based on the severity of maternal hypercholanemia.MethodsA hospital-based retrospective cohort study was performed between January 1, 2015, and December 31, 2019. A total of 227 nulliparous women with a singleton fetus complicated by ICP were included. The patients were divided into two groups according to the levels of total bile acids, that is, mild (10 μmol/L &lt; total bile acids &lt; 40 μmol/L) and severe (≥40 μmol/L). The patients' clinical characteristics and fetal outcomes were assessed.ResultsAmong the 227 eligible women, 177 (78.0%) were allocated to the mild group and 50 (22.0%) were in the severe group. Women with severe ICP also had a significantly higher incidence of planned and unplanned CS compared with mild ICP subjects (52.0% vs. 23.7% and 22.0% vs. 6.8%, respectively; p &lt; 0.001). The indications for CS showed that fetal intolerance (65.4% vs. 14.3%) was higher in severe ICP compared with mild ICP (p &lt; 0.001). Severe ICP was associated with an increased risk of preterm delivery (p &lt; 0.001), low birthweight (p = 0.001), and neonatal intensive care unit (NICU) admission (p &lt; 0.001). Women with severe ICP (OR 6.397, 95%CI 3.041–13.455, p &lt; 0.001) or preeclampsia (OR 12.434, 95%CI 5.166–29.928, p &lt; 0.001) had increased risks of AFOs compared to controls.ConclusionsSevere ICP and preeclampsia are associated with a higher incidence of AFOs.
Trend of fetal echocardiography use and comparison of medical costs for congenital heart disease treatment based on fetal echocardiography use in a Korean single center
Authors: Choi Ho-Jung , Song Mi-Kyoung , Lee Sang-Yun , Kim Gi-Beom , Bae Eun-Jung , Park Joong-Shin , Jun Jong-Kwan , Kwon Hye-Won , Lim Hong-Gook , Kim Woong-Han 
Published: June 2023

BackgroundThe rate of the prenatal diagnosis of congenital heart disease is increasing along with advances in fetal echocardiography techniques. Here, we aimed to investigate the trend of the use of fetal echocardiography over time and to compare the medical costs of congenital heart disease treatment according to whether fetal echocardiography was performed.MethodsWe reviewed our hospital’s database, and patients who underwent the first surgery for congenital heart disease within 30 days of birth during 2005–2007, 2011–2013, and 2017–2019 were included. The severity of congenital heart disease diagnosed in each case was evaluated according to The Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Congenital Heart Surgery Mortality Scores (STS-EACTS Mortality Scores) and Mortality Categories (STAT Mortality Categories).ResultsIn total, 375 patients were analyzed, and fetal echocardiography use increased significantly after the 2010s compared with in 2005–2007 (19.1% vs. 39%, p = 0.032 in Mortality Category 1–3; 15.5% vs. 69.5%, p = 0.000 in Mortality Category 4–5). Additionally, the mean STS-EACTS Mortality Score was higher in prenatally diagnosed patients than in postnatally diagnosed patients (2.287 vs. 1.787, p = 0.001). In the recent period, there was no significant difference in hospitalization durations and medical costs according to whether or not fetal echocardiography was performed.ConclusionsThis single center study showed the use of fetal echocardiography is increasing. Further, prenatal diagnosis with fetal echocardiography causing no differences in medical costs in recent years. Therefore, we suggest that fetal echocardiography can be applied more widely without increasing the economic burden.
Development of evidence-based indicators for the detection of drug-related problems among ovarian cancer patients
Authors: Rawal Kala Bahadur , Mateti Uday Venkat , Shetty Vijith , Shastry Chakrakodi Shashidhara , Unnikrishnan Mazhuvancherry Kesavan , Shetty Shraddha , Rajesh Aparna 
Published: June 2023

Background: Antineoplastic drugs produce serious drug-related problems and their management is challenging. DRPs are critical, for saving on therapeutic costs, particularly in resource poor settings within low-middle-income countries such as India. Indicators are clues that helps to detect DRPs within the healthcare organization and minimize overall harm from medications. Indicators enable healthcare professionals to determine the future therapeutic course. And enable healthcare professionals to take a proactive stand, and stay informed and empowered to both prevent and manage DRPs. This study aims to develop evidence-based indicators for detecting potential drug-related problems in ovarian cancer patients.Patients and Methods: A retrospective study was conducted in the Department of Oncology of a tertiary care teaching hospital in South India. Based on literature search, we developed a list of indicators, which were validated by a Delphi panel of multidisciplinary healthcare professionals (16 members). Based on 2 years of ovarian cancer data, we performed a feasibility test retrospectively and classified the DRPs according to the Pharmaceutical Care Network Europe classification of DRPs version-9.1.Results: The feasibility test identified 130 out of 200 indicators. A total of 803 pDRPs were identified under four main categories: drug selection problem, drug use problem, adverse drug reaction and drug-drug interaction The most frequently observed were ADR 381 (47.45%), DDIs 354 (44.08%), and drug selection problems 62 (7.72%).Conclusion: Indicators developed by us effectively identified pDRPs in ovarian cancer patients, which can potentially help healthcare professionals in the early detection, timely management, and attenuating severity of DRPs. Identifying the pDDIs can potentially improve interdisciplinary involvement and task sharing, including enhanced pharmacists’ participation within the healthcare team.
Reading-to-Writing Mediation model of higher-order literacy
Authors: Ahmed Yusra , Kent Shawn C. , Keller-Margulis Milena 
Published: June 2023

IntroductionWriting difficulties frequently manifest comorbidly with reading challenges, and reading is implicated in particular acts of writing, such as reviewing and editing. Despite what is known, however, there remain significant barriers to understanding the nature of reading-writing relations, as few studies are comprehensive in the number and types of literacy skills evaluated. This study consists of a secondary data analysis of two studies employing structural equation modeling (SEM) to evaluate relations among reading and writing components skills independently, using the Direct and Inferential Mediation Model (DIME) of reading comprehension and Not-so-Simple View of Writing (NSVW) as theoretical frameworks.MethodsWe examine relations between reading and writing components from these models with a sample of upper elementary students with/at-risk for learning disabilities (n= 405). Lower-order components included word reading, vocabulary, handwriting and spelling. Higher-order components included background knowledge, reading strategies, inferencing, planning, editing, and revision. The literacy outcomes were oral and silent reading fluency, reading comprehension, and writing quality and productivity. We systematically build a Reading-to-Writing Mediation (RWM) model by first merging the DIME and NSVW components in a direct effects model (Aim 1), expanding the joint model to include reading and writing fluency (Aim 2), evaluating indirect effects between DIME and NSVW component skills (Aim 3), and finally, evaluating indirect effects with reading and writing fluency (Aim 4).ResultsThe findings suggest that higher order fluency and comprehension skills are differentially related to writing activities and products.DiscussionThe pattern of results helps elucidate the mechanisms of how various reading and writing skills transfer and relate. The results have implications for targeted and implicit instruction in multicomponent interventions and the use of screeners to identify areas of risk.
Continuance intention to use mobile learning for second language acquisition based on the technology acceptance model and self-determination theory
Authors: He Limin , Li Chunming 
Published: June 2023

IntroductionThis study examines the factors that predict Chinese students’ continuance intention to use mobile learning for second language acquisition based on the technology acceptance model and self-determination theory.MethodOne hundred seventy undergraduates have participated in the survey and the structural equation modeling is conducted to assess the validity of the integrated model and hypotheses.ResultsThe findings show that instructor support can significantly predict autonomy, competence and relatedness. Autonomy and competence are positively related to perceived ease of use and continuance intention to use mobile learning for English acquisition. Relatedness significantly correlates with perceived ease of use but is not directly related to learners’ continuance intention. The relationship between perceived ease of use and continuance intention to adopt mobile learning is positive and significant. In addition, the results show that instructor support, autonomy, relatedness, competence and perceived ease of use can predict Chinese students’ continuance intention to use m-learning for second language acquisition, with 70.5% of the total variance in continuance intention being explained by these five variables.ConclusionThese results thus empirically support the integrated model, which can be used as a theoretical framework in future studies on mobile learning in higher education contexts. Moreover, the results of this study have a number of practical implications for universities and instructors.
Technostress and academic motivation: direct and indirect effects on university students' psychological health
Authors: Vallone Federica , Galvin John , Cattaneo Della Volta Maria Francesca , Akhtar Athfah , Chua Stephanie , Ghio Emilie , Giovazolias Theodoros , Kazakou Zoe , Kritikou Marina , Koutra Katerina , Kovacevic Sanja , Lee-Treweek Geraldine , Mašková Ivana , Mavritsaki Eirini , Nastic Jelena , Plassova Michala , Stuchlíková Iva , Zurlo Maria Clelia 
Published: June 2023

IntroductionResearch has well demonstrated that the pandemic entailed several implications among university students worldwide in terms of increased use of Information and Communication Technologies (ICTs), technostress, disruptions in academic goals and motivation processes, and growing psychological suffering. Responding to the new research need to go in-depth into the processes linking technostress and motivation dimensions to inform current research/interventions, the present study aimed to explore the direct effects of perceived Technostress dimensions (Techno-Overload, Work-Home Conflict, Pace of Change, Techno-Ease, Techno-Reliability, and Techno-Sociality) and Academic Motivation dimensions (Amotivation, Intrinsic, and Extrinsic Motivation dimensions) on students' perceived levels of Anxiety/Depression and test the potential indirect effect (mediating role) of Academic Motivation dimensions in the associations between Technostress and psychological health conditions.MethodsOverall, 1,541 students from five European countries (Czech Republic, Greece, Italy, Serbia, United Kingdom) completed a survey comprising a Background Information Form, the Technostress Scale, the Academic Motivation Scale-College, and the Hospital Anxiety and Depression Scale. Hayes' PROCESS tool was used to test direct and indirect (mediating) effects.ResultsData revealed that Techno-Overload, Work-Home Conflict, Amotivation, and Extrinsic Motivation-Introjected had a direct negative effect, whereas Techno-Ease, Techno-Reliability, Techno-Sociality, all Intrinsic Motivation dimensions, and Extrinsic Motivation-Identified had a direct protective role for students' psychological health. The significant indirect role of motivation dimensions in the associations between Technostress dimensions and Anxiety/Depression was fully supported.DiscussionFindings allow gaining further insight into the pathways of relationships between technostress, motivation, and psychological health, to be used in the current phase, featured by the complete restoration of face-to-face contacts, to inform the development of tailored research and interventions, which address lights and shadows of the technology use, and which take into account the necessity to enhance its potentials yet without impairing students' motivation and psychological health.
The influence of social alienation on maintenance hemodialysis patients’ coping styles: chain mediating effects of family resilience and caregiver burden
Authors: Liu Qiaoling , Zhang Li , Xiang Xia , Mao Xiaoying , Lin Ying , Li Jingfeng , Cui Wen 
Published: June 2023

ObjectiveResearch on the possible impact of social alienation, family resilience, and caregiver burden on the coping styles of Chinese patients on maintenance hemodialysis (MHD) is scarce. We explore the influence of social alienation, family resilience, and caregiver burden on the coping styles of MHD patients, both directly and indirectly.MethodsWe invited 173 MHD patients and their primary caregivers for a cross-sectional study; the study using convenience sampling method at the hemodialysis center of the First People’s Hospital of Foshan. The Chinese version of the generalized social of alienation scale, the Chinese version of the simplified coping style questionnaire, and a sociodemographic questionnaire were completed by the MHD patients, while their primary caregivers had filled out the Chinese family resilience assessment scale, the Chinese version of the Zarit caregiver burden interview, and provided socio-demographic information. SPSS macro program PROCESS v3.3 Model 6 were used for analyses of chain-mediated effects.ResultsIn the mediating effects model, the direct influence of social alienation upon coping styles was significant (95% CI −0.050, −0.014), and social alienation indirectly impacted coping style by family resilience in a significant way (95% CI −0.012, −0.001) or caregiver burden (95% CI −0.013, −0.001). In addition, social alienation significantly impacted coping style by both family resilience and caregiver burden (95% CI −0.008, −0.001).ConclusionSocial alienation can exert both a direct and indirect influence on coping styles through the mediating factors of family resilience and caregiver burden. Clinicians can take interventions to strengthen family resilience and reduce caregiver burden, which may be useful in improving socially isolated behaviors and coping skills in MHD patients.