bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smartphone-based point-of-care anemia screening in rural Bihar in India
Authors: Haggenmüller Verena , Bogler Lisa , Weber Ann-Charline , Kumar Abhijeet , Bärnighausen Till , Danquah Ina , Vollmer Sebastian 
Published: March 2023

Abstract
Background
The high prevalence of anemia in resource-constrained settings calls for easy-to-use, inexpensive screening tools. The Sanguina Smartphone App, an innovative tool for non-invasive hemoglobin estimation via color-sensitive, algorithm-based analysis of fingernail bed images, was validated in the United States. This study evaluates the performance of the App in a population with different socio-economic, ethnic, demographic and cultural composition in rural Bihar, India.

Methods
For 272 mainly adult patients of a private health centre, hemoglobin measurement with the App is compared with the gold standard laboratory blood analysis. For a second sample of 179 children attending pre-schools, hemoglobin measurement with the App is compared to the results of the HemoCue Hb 301, a point-of-care device using a small blood sample, serving as the reference standard for field-based settings.

Results
The App reaches ±4.43 g/dl accuracy and 0.38 g/dl bias of comparator values in the clinic-based sample, and ±3.54 g/dl and 1.30 g/dl, respectively in the pre-school sample. After retraining the algorithm with the collected data, the validity of the upgraded version is retested showing an improved performance (accuracy of ±2.25 g/dl, bias of 0.25 g/dl), corresponding to the results of the original validation study from the United States.

Conclusions
The initial version of the App does not achieve the accuracy needed for diagnosis or screening. After retraining the algorithm, it achieves an accuracy sufficient for screening. The improved version with the potential for further adaptions is a promising easy-to-use, inexpensive screening tool for anemia in resource-constrained point-of-care settings.
Major depression, physical health and molecular senescence markers abnormalities
Authors: Seitz-Holland Johanna , Mulsant Benoit H. , Reynolds III Charles F. , Blumberger Daniel M. , Karp Jordan F. , Butters Meryl A. , Mendes-Silva Ana Paula , Vieira Erica L. , Tseng George , Lenze Eric J. , Diniz Breno S. 
Published: March 2023

AbstractPrevious studies suggested the role of cellular senescence in late-life depression (LLD). However, it is unclear how this finding relates to common features of LLD, such as medical and cognitive problems. We applied factor analyses to an extensive battery of clinical variables in 426 individuals with LLD. Here we tested the relationship between these factors, age and sex, with an index of cellular senescence based on 22 senescence-associated secretory phenotype proteins. We found four factors: ‘depression and anxiety severity’, ‘cognitive functioning’, ‘cardiovascular and cardiometabolic health’ and ‘blood pressure’. A higher senescence-associated secretory phenotype index was associated with poorer ‘cognitive functioning’ and ‘cardiovascular and cardiometabolic health’ but not with ‘depression and anxiety severity’. These findings highlight the role of cellular senescence in poorer physical and cognitive health in LLD. They are consonant with the viewpoint that co-occurring medical burdens and their associated disabilities are part of a phenotype of accelerated ageing in LLD.
High-Speed Videoendoscopic and Acoustic Characteristics of Inspiratory Phonation
Authors: Patel Rita R. , Sandage Mary J. , Golzarri-Arroyo Lilian 
Published: March 2023

Purpose:
Given the importance of inspiratory phonation for assessment of vocal fold structure, the aim of this investigation was to evaluate and describe the vocal fold vibratory characteristics of inspiratory phonation using high-speed videoendoscopy in healthy volunteers. The study also examined the empirical relationship between cepstral peak prominence (CPP) and glottal area waveform measurements derived from simultaneous high-speed videoendoscopy and audio recordings.

Method:
Vocally healthy adults (33 women, 28 men) volunteered for this investigation and completed high-speed videoendoscopic assessment of vocal fold function for two trials of an expiratory/inspiratory phonation task at normal pitch and normal loudness. Twelve glottal area waveform measures and acoustic CPP values were extracted for analyses.

Results:
Inspiratory phonation resulted in shorter closing time, longer duration of the opening phase, and faster closing phase velocity compared to expiratory phonation. Sex differences were elucidated. CPP changes for inspiratory phonation were predicted by changes in the glottal area index and waveform symmetry index, whereas changes in CPP during expiratory phonation were predicted by changes in asymmetry quotient, glottal area index, and amplitude periodicity.

Conclusions:
Vocal fold vibratory differences were identified for inspiratory phonation when compared to expiratory phonation, the latter of which has been studied more extensively. This investigation provides important basic inspiratory phonation data to better understand laryngeal physiology in vivo and provides a basic model from which to further study inspiratory phonation in a larger population representing a broader age range.

Supplemental Material:

https://doi.org/10.23641/asha.22223812
The distribution of globular clusters in kinematic spaces does not trace the accretion history of the host galaxy
Authors: Pagnini G. , Di Matteo P. , Khoperskov S. , Mastrobuono-Battisti A. , Haywood M. , Renaud F. , Combes F. 
Published: March 2023

Context. Reconstructing how all the stellar components of the Galaxy formed and assembled over time by studying the properties of the stars that form it is the aim of Galactic archaeology. Thanks to the launch of the ESA Gaia astrometric mission and the development of many spectroscopic surveys in recent years, we are for the first time in the position to delve into the layers of the past of the Galaxy. Globular clusters play a fundamental role in this research field since they are among the oldest stellar systems in the MW and thus bear witness to its entire past.
Aims. As a natural result of galaxy formation, globular clusters did not necessarily all form in the Galaxy itself. Indeed, a fraction of them could have been formed in satellite galaxies accreted by the Milky Way over time. In recent years, there have been several attempts to constrain the nature of clusters (accreted or formed in the Milky Way itself) through the analysis of kinematic spaces, such as the E − Lz, Lperp − Lz, eccentricity − Lz, and the action space, as well as attempts to reconstruct the properties of the accretion events experienced by the Milky Way through time from this kind of analysis. This work aims to test a widely used assumption about the clustering of the accreted populations of globular clusters in the integrals of motions space.
Methods. In this paper we analyse a set of dissipationless N-body simulations that reproduce the accretion of one or two satellites with their globular cluster population on a Milky Way-type galaxy.
Results. Our results demonstrate that a significant overlap between accreted and ‘kinematically heated’ in situ globular clusters is expected in kinematic spaces for mergers with mass ratios of 1:10. In contrast with the standard assumptions made in the literature so far, we find that accreted globular clusters do not show dynamical coherence, that is, they do not cluster in kinematic spaces. In addition, we show that globular clusters can also be found in regions dominated by stars that have a different origin (i.e. a different progenitor). This casts doubt on the association between clusters and field stars that is generally made in the literature and is used to assign them to a common origin. By means of Gaussian mixture models, we demonstrate that the overlap of clusters is not only a projection effect on specific planes but is also found when the whole set of kinematic properties (i.e. E, Lz, Lperp, eccentricity, radial, and vertical actions) is taken into account. Overall, our findings severely question the recovered accretion history of the Milky Way based on the phase-space clustering of the globular cluster population.
30 Jahre gesamtdeutsche Balintarbeit und ihre Wurzeln
Authors: Otten Heide 
Published: March 2023

ZusammenfassungDie Balintarbeit in Deutschland hat zwei Wurzeln. Sie entwickelte sich in der BRD
und in der DDR parallel bis es 1991/92 zum Zusammenschluss der beiden
Balintgesellschaften Ost und West kam.
Understanding and Describing London Dispersion Effects in ­Transition-Metal-Catalyzed C–H Activations
Authors: Yuan Binbin , Oliveira João C. A. , Ackermann Lutz 
Published: March 2023

AbstractTransition-metal-catalyzed C–H activation has emerged as a powerful strategy for molecular synthesis with unique levels of resource economy. Weak secondary dispersion interactions were found to play an essential role in these transformations in terms of kinetic efficacy and selectivity. This Account summarizes our group’s recent progress in the rationalization and quantification of London dispersion effects within the transition-metal-catalyzed C–H activation.1 Introduction2 Annulation Reactions3 Alkylation Reactions4 Arylation Reactions5 Olefination Reactions6 Oxygenation Reactions7 Conclusion
Modified Trans-Sinusal Transglabellar Approach for Anterior Cranial Fossa Meningiomas: Technical Note and Literature Review
Authors: Siqueira Bruno Lobo Mota de , Lemos Luiz Euripedes Almondes Santana , Araújo Maysa Gomes Ferreira de , Silva Rhuann Pontes dos Santos , Araújo Mayle Gomes Ferreira de , Cortez Fabíola Gissel , Filho Hildo Rocha Cirne de Azevedo 
Published: March 2023

Abstract
Introduction Currently, skull base surgery faces the dilemma of achieving the maximum possible tumor resection through less aggressive approaches and with minimal retraction of brain tissue. The objective of this work is to report a minimally invasive step-by-step approach to anterior cranial fossa tumors and to perform a literature review.
Methods In our work, we describe a step-by-step approach, with images, which is a variation of the transglabellar approach.
Results In all cases, we achieved maximum total resection of the lesion. There were no postoperative complications related to the surgery. In one case, we used the access to remove a foreign body in the frontal lobe.
Conclusion The frontal trans-sinusal transglabellar access allows direct access to anterior cranial fossa tumors and other frontal lobe lesions close to the floor of the anterior fossa, without the need for brain retraction, allowing early devascularization of the tumor. However, this access is not recommended for all types of tumors, and is being improved for more anteriorly located lesions.
Effect of implementing care protocols on acute ischemic stroke outcomes: a systematic review
Authors: Leite Karina Fonseca de Souza , Faria Mariana Gaspar Botelho Funari de , Andrade Rubia Laine de Paula , Sousa Keila Diane Lima de , Santos Samuel Ribeiro dos , Ferreira Kamila Santos , Rezende Carlos Eduardo Menezes de , Neto Octavio Marques Pontes , Monroe Aline Aparecida 
Published: March 2023

Abstract
Background Implementing stroke care protocols has intended to provide better care quality, favor early functional recovery, and achieving long-term results for the rehabilitation of the patient.
Objective To analyze the effect of implementing care protocols on the outcomes of acute ischemic stroke.
Methods Primary studies published from 2011 to 2020 and which met the following criteria were included: population should be people with acute ischemic stroke; studies should present results on the outcomes of using protocols in the therapeutic approach to acute ischemic stroke. The bibliographic search was carried out in June 2020 in 7 databases. The article selection was conducted by two independent reviewers and the results were narratively synthesized.
Results A total of 11,226 publications were retrieved in the databases, of which 30 were included in the study. After implementing the protocol, 70.8% of the publications found an increase in the rate of performing reperfusion therapy, such as thrombolysis and thrombectomy; 45.5% identified an improvement in the clinical prognosis of the patient; and 25.0% of the studies identified a decrease in the length of hospital stay. Out of 19 studies that addressed the rate of symptomatic intracranial hemorrhage, 2 (10.5%) identified a decrease. A decrease in mortality was mentioned in 3 (25.0%) articles out of 12 that evaluated this outcome.
Conclusions We have identified the importance of implementing protocols in increasing the performance of reperfusion therapies, and a good functional outcome with improved prognosis after discharge. However, there is still a need to invest in reducing post-thrombolysis complications and mortality.
High performance older adults in a population-based sample with low education: Pietà study
Authors: Carmona Karoline Carvalho , Resende Elisa de Paula França , Guimarães Henrique Cerqueira , Machado Thais Helena , Amaral-Carvalho Viviane , Santos Etelvina Lucas dos , Barbosa Maira Tonidandel , Caramelli Paulo 
Published: March 2023

Abstract
Background Healthy brain aging can be defined as aging without neurological or psychiatric disorders, sustaining functional independence. In addition to the absence of disease and preserved functionality, there are individuals who stand out for their superior performance to that considered normal for their age in cognitive tests. These individuals are called “high-performance older adults” (HPOA).
Objectives To investigate the presence of HPOA in an oldest-old population with low education, and if present, to investigate associations with sociodemographic, clinical, and lifestyle variables.
Methods We evaluated 132 cognitively healthy individuals from the Pietà Study, a population-based investigation with 639 participants. We used the delayed recall from the Rey Auditory-Verbal Learning Test to verify the existence of HPOA and to classify participants based on their performance. Sociodemographic, clinical, and lifestyle variables associated with HPOA were investigated.
Results We identified 18 individuals fulfilling HPOA criteria (age: 77.4 ± 2.6 years old; 14 women; education: 4.6 ± 3.4 years). The other participants, 114 total (age: 79.8 ± 4.5 years old; 69 women; education: 3.0 ± 2.7 years) were classified as “standard performance older adults” (SPOA). In multivariate analysis, younger age (odds ratio [OR] = 0.672; 95% confidence interval [CI]: 0.462–0.979; p = 0.037) and lower scores on the Geriatric Depression Scale (OR = 0.831; 95%CI: 0.688–0.989; p = 0.038) were associated with HPOA.
Conclusions The present study identifies for the first time HPOA with low educational level, thereby reinforcing the existence of biological substrates related to this condition. Furthermore, the data suggest an association between younger age and less depressive symptoms with HPOA.
Cognitive evaluation in Parkinson's disease: applying the Movement Disorder Society recommendations in a population with a low level of formal education
Authors: Rocha Natalia Pessoa , Carreira Eduarda Xavier , Prado Ana Carolina de Almeida , Tavares Fabíola , Tavares Mayra , Cardoso Francisco , Jaeger Antônio , Souza Leonardo Cruz de , Teixeira Antônio Lucio 
Published: March 2023

Abstract
Background The diagnosis of cognitive disorders in Parkinson disease (PD) can be very challenging. Aiming at establishing uniform and reliable diagnostic procedures, the International Parkinson's Disease and Movement Disorder Society (MDS) commissioned task forces to delineate diagnostic criteria for mild cognitive impairment (MCI) and dementia in PD.
Objectives To investigate the applicability of the MDS recommendations for cognitive evaluation in a Brazilian sample of patients with PD with low levels of formal education.
Methods A total of 41 patients with PD were subjected to a comprehensive neuropsychological evaluation based on tests proposed by the MDS, which included the Mini-Mental State Examination, the Mattis Dementia Rating Scale (MDRS), the Trail Making Test (TMT) parts A and B, in addition to language and memory skills assessment. Neuropsychiatric and daily functioning features were also evaluated. Spearman correlation analyses were used to evaluate the association between the scores obtained in the cognitive scales and demographic/clinical variables.
Results Although none of the participants had a formal diagnosis of dementia, 50% presented some degree of cognitive impairment when considering the results of the MDRS. Of note, a noticeable number of patients was not able to complete the full neuropsychological assessment. The TMT part B was the most difficult task, being completed by only 22 participants (54%). As expected, the greater the educational level, the better the performance on the cognitive tests. Better motor function was also associated with better scores in cognition.
Conclusions Adopting strict inclusion/exclusion criteria and a comprehensive clinical evaluation, we found remarkable limitations for the MDS recommendations when individuals with low educational levels are considered. A revision of the current guidelines is necessary considering differences among populations, especially related to formal education.
Neuromyelitis optica spectrum disorders: a review with a focus on children and adolescents
Authors: Paolilo Renata Barbosa , Paz José Albino da , Apóstolos-Pereira Samira Luisa , Rimkus Carolina de Medeiros , Callegaro Dagoberto , Sato Douglas Kazutoshi 
Published: March 2023

AbstractNeuromyelitis optica spectrum disorder (NMOSD) is a rare and severe inflammatory disorder of the central nervous system (CNS). It is strongly associated with anti-aquaporin 4 antibodies (AQP4-IgG), and it mainly affects young women from non-white ethnicities. However, ∼ 5 to 10% of all cases have onset during childhood. Children and adolescents share the same clinical, radiologic, and laboratory presentation as adults. Thus, the same NMOSD diagnostic criteria are also applied to pediatric-onset patients, but data on NMOSD in this population is still scarce. In seronegative pediatric patients, there is a high frequency of the antibody against myelin oligodendrocyte glycoprotein (MOG-IgG) indicating another disease group, but the clinical distinction between these two diseases may be challenging. Three drugs (eculizumab, satralizumab, and inebilizumab) have been recently approved for the treatment of adult patients with AQP4-IgG-positive NMOSD. Only satralizumab has recruited adolescents in one of the two pivotal clinical trials. Additional clinical trials in pediatric NMOSD are urgently required to evaluate the safety and efficacy of these drugs in this population.
Correlation of brain segmental volume changes with clinical parameters: a longitudinal study in multiple sclerosis patients
Authors: Eskut Neslihan , Koc Ali Murat , Koskderelioglu Asli , Dilek Ismail , Tekindal Mustafa Agah 
Published: March 2023

Abstract
Objective To measure the cranial volume differences from 15 different parts in the follow-up of relapsing-remitting multiple sclerosis (RRMS) patients and correlate them with clinical parameters.
Methods Forty-seven patients with RRMS were included in the study. Patients were grouped into two categories; low Expanded Disability Status Scale (EDSS) (< 3; group 1), and moderate-high EDSS (≥ 3; group 2). Patients were evaluated with Beck Depression Inventory (BDI), Montreal Cognitive Assessment (MOCA), Symbol Digit Modalities Test (SDMT), Fatigue Severity Scale (FSS), and calculated Annualized Relapse Rate (ARR) scores. Magnetic resonance imaging (MRI) was performed with a 1.5T MRI device (Magnetom AERA, Siemens, Erlangen, Germany) twice in a 1-year period. Volumetric analysis was performed by a free, automated, online MRI brain volumetry software. The differences in volumetric values between the two MRI scans were calculated and correlated with the demographic and clinical parameters of the patients.
Results The number of attacks, disease duration, BDI, and FSS scores were higher in group 2; SDMT was higher in group 1. As expected, volumetric analyses have shown volume loss in total cerebral white matter in follow-up patients (p < 0.001). In addition, putaminal volume loss was related to a higher number of attacks. Besides, a negative relation between FSS with total amygdala volumes, a link between atrophy of globus pallidus and ARR, and BDI scores was found with the aid of network analysis.
Conclusions Apart from a visual demonstration of volume loss, cranial MRI with volumetric analysis has a great potential for revealing covert links between segmental volume changes and clinical parameters.
Neutrinos, mixed bosons, quantum reference frames and entanglement
Authors: Capolupo A , Quaranta A 
Published: March 2023

Abstract
We discuss the relevance of quantum reference frames in the description of mixed particle states. We show that the notion of a rest frame for mixed particles, which is classically ill-defined, can be introduced in the context of quantum frames. We discuss the possible implications, displaying a new form of frame-dependent entanglement that characterizes reactions involving mixed particles, and suggest a possible route to extract observables related to such an entanglement.
Ambiguities in a partial-wave analysis of γ
p → π
0
p with truncation in total angular momentum
Authors: Fix A , Dementjev I 
Published: March 2023

Abstract
We address some questions related to the discrete ambiguity problem in a truncated partial-wave analysis in the case when the helicity basis together with truncation in total angular momentum j is employed. As a numerical application, we consider the case

j

max

=
3

/

2

using as input the MAID2007 and SAID multipoles in the γ
p → π
0
p channel.
Magnetic excitations in the helical Rashba superconductor
Authors: Akbari Alireza , Thalmeier Peter 
Published: March 2023

Abstract
We investigate the magnetic excitation spectrum in the helical state of a noncentrosymmetric superconductor with inversion symmetry breaking and strong Rashba spin–orbit coupling. For this purpose we derive the general expressions of the dynamical spin response functions under the presence of strong Rashba splitting of conduction bands, superconducting gap and external field which lead to stabilization of Cooper pairs with finite overall momentum in a helical state. The latter is characterized by momentum space regions of paired and unpaired states with different quasiparticle dispersions. The magnetic response is determined by i) excitations within and between both paired and unpaired regions ii) anomalous coherence factors and iii) additional spin matrix elements due to helical Rashba spin texture of bands. We show that as a consequence typical correlated real space and spin space anisotropies appear in the dynamical susceptibility which would be observable as a characteristic fingerprint for a helical superconducting state in inelastic neutron scattering investigations.