bluuebunny/crossref_metadata_2025_split huggingface dataset:
A reliable alternating multi‐path transmission control protocol scheduling for bandwidth aggregation performance
Authors: Bencheikh Mohammed , Zouaoui Chakib , Taleb Nasreddine , Boukelif Aoued , Benaouda Chaht Afaf , Naimi Mohamed 
Published: May 2023

SummaryThe Multi‐Path Transmission Control Protocol is a new generation protocol for the transport layer which allows multihomed devices to exploit simultaneously their own interfaces. This feature would normally lead to some high‐performance achievement in regard to regular TCP. However, the heterogeneous paths might cause the occurrence of the 'out‐of‐order' problem which requires the intervention of a more efficient scheduler to reach a high level of global bandwidth utilization. Since scheduling plays a key role in performance improvements, several studies have been implemented exploiting this idea, namely those that adopt the reactive approach and those others adopting the proactive one. In this paper, our goal is to improve the multipath throughput. The testbed experimentation consists primarily in the evaluation and analysis of the behaviour of different recent scheduling approaches with an asymmetric paths topology. Then, we propose an alternating scheduling approach which shed the light on bandwidth utilization. The results show that this approach is a more efficient solution than taking the reactive and proactive ones separately as it is based on a preliminary study that we conducted on the main performance and reliability parameters and has been implemented in the asymmetric multipath networks. This technique has led to a smart scheduling that provides a high level of throughput aggregation.
Magnetic Solid‐Phase Extraction of Fipronil from Aqueous Solution and Eggshells Using Amine‐Coated Iron Oxide Nanoparticles
Authors: Camızcı Aran Gülnur , Bayraç Ceren 
Published: May 2023

AbstractFipronil, as a broad use insecticide, is regulated under directives and standards in many countries since it is classed as Class II moderately hazardous pesticide and Group C possible human carcinogen. In this study, amine coated iron oxide (NH2−Fe3O4) is used as a new adsorbent with high adsorption capacity in the removal of fipronil from aqueous solution and eggshells.The adsorption performance was studied through batch adsorption under different concentrations of fipronil (10–200 μg/mL), different nanoparticles amount (0.1–1 mg) at different pH (4.5–6.0) and temperature (25–75 °C). Results showed that NH2−Fe3O4 nanoparticles (0.1 mg) have excellent adsorption efficiency (97.06 %) at 25 °C, and pH 5.5. It also showed higher adsorption capacity towards fipronil sulfide, fipronil sulfone and fipronil desulfinyl with removal efficiencies of 92.82 %, 86.35 % and 76.24 % from aqueous solution and 97.62 %, 76.97 % and 62.65 % from eggshells, respectively. Fipronil adsorption process on NH2−Fe3O4 nanoparticles showed best fitting to Langmuir adsorption isotherm indicating monolayer chemical adsorption by physicochemical interactions spontaneously on homogenous surfaces. Having higher adsorption capacity and reusability NH2−Fe3O4 nanoparticles were shown to be effective adsorbents for removal of fipronil from aqueous solution and eggshells.
Investigating Neural Correlates of Behavior Through In Vivo Electrophysiology
Authors: Halladay Lindsay R. 
Published: May 2023

AbstractBehavioral neuroscience has long relied on in vivo electrophysiology to provide spatially and temporally precise answers to complex questions about the neural dynamics underlying sensory processing and action execution. Investigating the neural correlates of behavior can be challenging in freely behaving animals, especially when making inferences related to internal states that are temporally or conceptually ambiguous, such as decision‐making or motivation. This necessitates careful creation of appropriate and rigorous controls and awareness of the many potential confounds when attributing neural signals to animal behavior. This article discusses fundamental considerations for the optimal design and interpretation of in vivo rodent electrophysiological recording experiments and focuses on the different optimization strategies required when investigating neural encoding of external stimuli versus free behavior. The first protocol offers suggestions specific to intracranial surgical implantation of multielectrode arrays. The second protocol delves into optimization strategies and tips useful for designing and interpreting recording experiments conducted in freely behaving rodents. © 2023 Wiley Periodicals LLC.Basic Protocol 1: Surgical implantation of the multielectrode arrayBasic Protocol 2: Optimizing experimental design and parameters
Safeguarding plant genetic resources in the United States during global climate change
Authors: Volk Gayle M. , Carver Dan , Irish Brian M. , Marek Laura , Frances Anne , Greene Stephanie , Khoury Colin K. , Bamberg John , del Rio Alfonso , Warburton Marilyn L. , Bretting Peter K. 
Published: May 2023

AbstractPlant genetic resources (PGR) underpin the security of global agriculture. Rapid global climate change presents formidable challenges for ex situ and in situ PGR management programs that operate over extended timeframes. The U.S. Department of Agriculture National Plant Germplasm System (NPGS) maintains more than 605,000 PGR accessions representing over 16,300 plant species in 20 genebank locations. These PGR are maintained in cold storage as seeds and vegetative tissues that must be periodically regenerated; or as actively growing plants in fields, greenhouses, screenhouses, and in vitro; or in some cases within in situ reserves. The complicated relationships between crops and their growth environments present unique challenges regarding PGR maintenance under a changing climate. Here we present potential effects of climate change on ex situ PGR maintenance and reproductive success, pollinators and beneficial insects, pathogens and pests, infrastructure considerations, and wild populations within NPGS in situ reserves. We provide a novel tool that summarizes past US temperature and precipitation data alongside future climate projections to guide ongoing planning for the effects of climate change for NPGS genebanks throughout the United States. A series of case studies exemplify instances where climate change has already impacted NPGS PGR management. Ongoing improvements to NPGS PGR management in response to climate change require continued observations of the current effects, careful and innovative planning, and creative approaches to ensure that PGR are successfully conserved for future generations.
Analytically pricing European options under a hybrid stochastic volatility and interest rate model with a general correlation structure
Authors: He Xin‐Jiang , Lin Sha 
Published: May 2023

AbstractIn this paper, an additional factor is introduced into the Heston–Hull–White (HHW) hybrid model, which originally combines the Heston stochastic volatility model and the Hull–White stochastic interest rate model, to capture the correlation between the underlying price and the interest rate, while at the same time preserve the analytical tractability. With the analytical solution to the characteristic function of the underlying price being successfully derived, a closed‐form pricing formula for European options under the two‐factor HHW hybrid model is presented. Numerical experiments are also carried out to show the effect of the newly introduced factor. To further demonstrate the importance of introducing the correlation, we have also conducted an empirical study, comparing the performance of our model and that of the HHW model, based on European options written on S&P 500 index.
Exploring the acute effects of running on cerebral blood flow and food cue reactivity in healthy young men using functional magnetic resonance imaging
Authors: Thackray Alice E. , Hinton Elanor C. , Alanazi Turki M. , Dera Abdulrahman M. , Fujihara Kyoko , Hamilton‐Shield Julian P. , King James A. , Lithander Fiona E. , Miyashita Masashi , Thompson Julie , Morgan Paul S. , Davies Melanie J. , Stensel David J. 
Published: May 2023

AbstractAcute exercise suppresses appetite and alters food‐cue reactivity, but the extent exercise‐induced changes in cerebral blood flow (CBF) influences the blood‐oxygen‐level‐dependent (BOLD) signal during appetite‐related paradigms is not known. This study examined the impact of acute running on visual food‐cue reactivity and explored whether such responses are influenced by CBF variability. In a randomised crossover design, 23 men (mean ± SD: 24 ± 4 years, 22.9 ± 2.1 kg/m2) completed fMRI scans before and after 60 min of running (68% ± 3% peak oxygen uptake) or rest (control). Five‐minute pseudo‐continuous arterial spin labelling fMRI scans were conducted for CBF assessment before and at four consecutive repeat acquisitions after exercise/rest. BOLD‐fMRI was acquired during a food‐cue reactivity task before and 28 min after exercise/rest. Food‐cue reactivity analysis was performed with and without CBF adjustment. Subjective appetite ratings were assessed before, during and after exercise/rest. Exercise CBF was higher in grey matter, the posterior insula and in the region of the amygdala/hippocampus, and lower in the medial orbitofrontal cortex and dorsal striatum than control (main effect trial p ≤ .018). No time‐by‐trial interactions for CBF were identified (p ≥ .087). Exercise induced moderate‐to‐large reductions in subjective appetite ratings (Cohen's d = 0.53–0.84; p ≤ .024) and increased food‐cue reactivity in the paracingulate gyrus, hippocampus, precuneous cortex, frontal pole and posterior cingulate gyrus. Accounting for CBF variability did not markedly alter detection of exercise‐induced BOLD signal changes. Acute running evoked overall changes in CBF that were not time dependent and increased food‐cue reactivity in regions implicated in attention, anticipation of reward, and episodic memory independent of CBF.
Longitudinal changes in swallowing function after surgery and proactive swallowing therapy for oral cancer
Authors: Meng Nai‐Hsin , Li Chia‐Ing , Hua Chun‐Hung , Lin Tzu‐Chieh , Chiu Chien‐Jen , Lin Chien‐Lin , Tsai Ming‐Hsui , Chiu Pei‐Ju , Chang Wen‐Dien , Tsou Yung‐An 
Published: May 2023

AbstractBackgroundThis study aimed to describe and explore the longitudinal changes in swallowing function among patients with oral cancer who underwent surgery and proactive swallowing therapy from baseline to 1‐year postoperation.MethodsWe retrospectively studied 118 patients over a 4.5‐year duration. Swallowing functional assessment including 10‐item Eating Assessment Tool (EAT‐10), Functional Oral Intake Scale (FOIS), M. D. Anderson Dysphagia Inventory, and Modified Barium Swallow Impairment Profile (MBSImP™) was performed at baseline, 1‐month, 6‐month, and 1‐year postoperatively.ResultsAll swallowing parameters worsened 1‐month postoperation. EAT‐10, FOIS, and MBSImP™ oral and pharyngeal impairment scores improved significantly compared with 1‐month postoperation at 6 months. Other swallowing parameters, except for weight, did not differ significantly from baseline at 6 months. The rate of tube‐feeding dependency was 11.5% and 5.6% at 1 and 6 months postoperation, respectively.ConclusionsPeriodic swallowing functional assessments help delineate the longitudinal changes in swallowing functional outcomes.
The relationship between safety‐net hospital status and outcomes among elderly head and neck cancer patients
Authors: Tashman Katherine , Noyes Elizabeth A. , Warinner Chloe B. , Ogbonna Joseph , Gomez Ernest , Jalisi Scharukh M. 
Published: May 2023

AbstractBackgroundThe impact of safety‐net status, case volume, and outcomes among geriatric head and neck cancer patients is unknown.MethodsChi‐square tests and Student's t tests to compare head and neck surgery outcomes of elderly patients between safety‐net and non‐safety‐net hospitals. Multivariable linear regressions to determine predictors of outcome variables including mortality index, ICU stays, 30‐day readmission, total direct cost, and direct cost index.ResultsCompared with non‐safety‐net hospitals, safety‐net hospitals had a higher average mortality index (1.04 vs. 0.32, p = 0.001), higher mortality rate (1% vs. 0.5%, p = 0.002), and higher direct cost index (p = 0.001). A multivariable model of mortality index found the interaction between safety‐net status and medium case volume was predictive of higher mortality index (p = 0.006).ConclusionSafety‐net status is correlated with higher mortality index and cost in geriatric head and neck cancer patients. The interaction between medium volume and safety‐net status is independently predictive of higher mortality index.
Incremental value of magnification and indocyanine green for parathyroid preservation in thyroid surgery
Authors: Shaphaba Konthoujam , Thakar Alok , Sakthivel Pirabu , Sikka Kapil , Singh Chirom Amit , Kumar Rajeev , Chandran Ashwin , Goswami Ravinder 
Published: May 2023

AbstractBackgroundTo assess the promise of surgical magnification and of intraoperative indocyanine green (ICG) assisted near‐infrared fluorescence (NIRF) in improving parathyroid identification and viability assessment during thyroidectomy.MethodsProspective comparative study. Parathyroid gland identification sequentially assessed by naked eye, surgical microscopy, and by NIRF imaging following ICG administration (5 mgIV). Parathyroid perfusion/vitality reassessed end‐surgery by ICG‐NIRF.ResultsAn expected total of 104 parathyroid glands were assessed in 35 patients (17 total‐thyroidectomy, 18 hemi‐thyroidectomy). 54/104 (51.9%) were identified by naked eye, and sequentially greater numbers identified by microscope magnification (n = 61; 58.7%; p = 0.33), and by ICG‐NIRF (n = 72; 69.2%; p = 0.01). ICG‐NIRF detected additional parathyroid glands in 16/35 patients (45.7%). Confident identification of at least one parathyroid remained unachieved in 5/35 by naked eye, in 4/35 by microscopic magnification, and in no patient by ICG‐NIRF. ICG‐NIRF indicated end‐of‐surgery devascularization in 12/72 glands and informed decisions regarding gland implantation.ConclusionSignificantly greater parathyroid glands are identified and preserved with surgical magnification and with ICG‐NIRF. Both techniques merit routine adoption for thyroidectomy.
Structural Insights into Electrophiles and Electrophilic Metabolites Sensing and Signaling: The Missing Information
Authors: Rogg Chloé , Aye Yimon 
Published: May 2023

AbstractNative reactive electrophilic species (RES) are long‐recognized regulators of pathophysiology; yet, knowledge surrounding how RES regulate context‐specific biology remains limited. The latest technological advances in profiling and precision decoding of RES sensing and signaling have begun to bring about improved understanding of localized RES regulatory paradigms. However, studies in purified systems — prerequisites for gaining structure/function insights — prove challenging. We here introduce emerging chemical biology tools available to probe RES signaling, and the new knowledge that these tools have brought to the field. We next discuss existing structural data of RES‐sensor proteins complexed with electrophilic metabolites or small molecule drugs (limited to <300 Da), including challenges faced in acquiring homogenous RES‐bound proteins. We further offer considerations that could promote enhanced understanding of RES regulation derived from three‐dimensional structures of RES‐modified proteins.
In search of a measure to investigate mental performance among children: Development of the mental speed test
Authors: Avcı‐Doğan Gülşah , Akbulut Yavuz , Sak Uğur 
Published: May 2023

AbstractProcessing speed is a component of general intelligence and an indicator of learning potential. There is a need for robust measures of mental speed based on contemporary theoretical developments. The current study addressed this need by proposing a mental speed test for children aged 60 to 96 months (5 to 8 years) and examining its psychometric properties. The test included indicators of perceptual speed, memory speed, reasoning speed, and fluency‐flexibility speed presented through nonverbal items administered individually using touchscreen tablets. After establishing gender non‐bias and concurrent validity with a contemporary intelligence test (i.e., ASIS, r = .59) with 107 children, the next administration included 373 children. Exploratory factor analysis (EFA) with subtest scores revealed a single‐factor structure accounting for 45% of the total variance. Additional data from 212 children were used to assess structural validity and gender bias, which showed acceptable goodness of fit, providing evidence of the validity and reliability of the new measure for further use.
Acetic acid‐induced colitis modulating potential of total crude alkaloidal extract ofPicralima nitidaseeds in rats
Authors: Otu‐Boakye Sarah A. , Yeboah Kofi O. , Boakye‐Gyasi Eric , Oppong‐Kyekyeku James , Okyere Prince D. , Osafo Newman 
Published: May 2023

AbstractPurposeThe total crude alkaloidal extract ofPicralima nitidaseeds (PNE) is known to possess anti‐inflammatory activity among other therapeutic benefits although its benefits in colitis has not been investigated. The current study therefore seeks to investigate the anti‐colitis potential of PNE using acetic acid‐induced colitis model in rats.MethodsSprague Dawley rats were treated with oral 500 mg/kg sulphasalazine or 30, 100, and 300 mg/kg of PNE daily for 8 days with induction of colitis on the fourth day with acetic acid. Rats were killed 24 h after the last treatment and whole blood was obtained from the jugular vein for hematological analysis and biochemical assays. Colons were extirpated for assessment of macroscopic and histological damage to the colon.ResultsTreatment with PNE protected against colonic injury induced with acetic acid by decreasing mucosal ulceration, epithelial erosion, inflammatory cell infiltration, and colonic edema. Thus, PNE preserved mucosal architecture and suppressed goblet cells depletion. Moreover, treatment with PNE was associated with improved hematological parameters and reductions in the expression of serum tumor necrosis factor‐alpha, interleukin‐1β, and p38 mitogen‐activated protein kinase. Also, PNE treatment exerted antioxidant effects by reducing nitric oxide production and increasing glutathione levels. In addition, PNE inhibited colonic lipid peroxidation by decreasing myeloperoxidase activity and malondialdehyde production.ConclusionIt can be concluded that PNE attenuates intestinal oxidative and inflammatory damages following intrarectal acetic acid challenge. Thus, demonstrates potential for use in chronic intestinal inflammatory diseases such as ulcerative colitis.
Ocular manifestations in Iranian patients referred to rheumatology clinics from 2018 to 2020
Authors: Pournazari Meharan , Hashemi Tara , Zarpoosh Mahsa , Amirian Parsa 
Published: May 2023

AbstractAimAutoimmune diseases are presented with many signs and symptoms. Eyes are commonly involved in these diseases. This study aimed to estimate the prevalence of different ophthalmological complications in patients with and without immune‐mediated rheumatological diseases.MethodsPatients who were referred to Kermanshah's rheumatologic clinics by an ophthalmologist from 2018 to 2020 for a rheumatologist visit were included. A checklist for extracting data from medical files; containing symptoms, organ involvement, ocular diseases diagnosed by an ophthalmologist, rheumatologic diseases diagnosed by a rheumatologist, lab tests, and disease progression was created. After we evaluated the medical data, we found that 54 patients out of 106 were diagnosed to have immune‐mediated rheumatological diseases. Patients were divided into two groups; the first group included patients with diagnosed immune‐mediated rheumatologic disease and ophthalmic complications; patients with no known immune‐mediated rheumatological disease were considered the second group. The obtained information was analyzed using statistical tests.ResultsOne hundred and six patients participated in this study, 67% of whom were females. The most common ocular symptom was blurred vision (49%). Involvement of both eyes (43.4%) was more common than single left or right eye involvement. The most common ophthalmic disease was anterior uveitis (35.8%). The most common rheumatologic disease was Behçet's disease (21.7%). Hypertension and hypothyroidism were the most common comorbidities; 36.7% of the patients had skin and mucous involvement, and 37.7% had joint involvement. In follow‐up of the ophthalmic symptoms, most patients were controlled partially. Ophthalmic diseases, laboratory tests, joint involvement, skin and mucous involvement, and lung involvement were associated with rheumatologic diseases.ConclusionEarly diagnosis of ocular involvement in rheumatologic diseases is crucial to prevent adverse complications. The results can be beneficial for a better perception of ophthalmic symptoms and diseases among patients with autoimmune diseases.
Vulvodynia: A practical guide in treatment strategies
Authors: Santangelo Giusi , Ruggiero Gianfilippo , Murina Filippo , Di Donato Violante , Perniola Giorgia , Palaia Innocenza , Fischetti Margherita , Casorelli Assunta , Giannini Andrea , Di Dio Camilla , Muzii Ludovico , Benedetti Panici Pierluigi , Bogani Giorgio 
Published: May 2023

AbstractVulvodynia is a debilitating condition characterized by chronic vulvar pain, with a detrimental impact on the patient's overall quality of life. Its etiology is multifactorial, but still in the process of being clearly outlined. Vulvodynia is not a single entity. It is a heterogeneous condition characterized by multiple triggers, making it challenging to define a reference standard for its treatment. In this manuscript we selected all articles including the following key criteria: “vulvodynia”. The primary outcomes observed included the resolution of chronic pelvic pain, dyspareunia and sexual satisfaction, psychological well‐being, and overall quality of life. Most pharmacologic treatments require further evidence to be recommended. On the other hand, non‐pharmacologic approaches such as psychotherapy, physical therapy, and surgery have received stronger support. This review summarizes pros and cons of adopting available treatments. Multimodal approaches should be introduced to improve patient outcomes. Further investigations are warranted to improve patients' quality of life.
Vaginal changes after ovariectomy in ewes: A large animal model for genitourinary syndrome of menopause
Authors: Vodegel Eva V. , Guler Zeliha , Ras Lamees , Mackova Katerina , Groeneveld Anne C. H. M. , Bezuidenhout Deon , Deprest Jan , Jeffery Stephen T. , Roovers Jan‐Paul W. R. 
Published: May 2023

AbstractObjectiveTo evaluate the effect of iatrogenic menopause on the physiology of the vagina of the ewe and to evaluate if vaginal changes in ewes can be translated to women with genitourinary syndrome of menopause (GSM).MethodsPreclinical research with Dohne Merino ewes. Iatrogenic menopause was induced by bilateral ovariectomy (OVX). Animals were randomized for surgery, blinded for allocation and outcome assessment. Differences between groups were determined by linear regression analyses at 5 months after OVX. Outcome measures were vaginal epithelial thickness, pH, vaginal maturation value, vaginal maturation index, epithelial glycogen accumulation, content of elastin fibers, collagen, and vascularity.ResultsOVX ewes (n = 20) showed epithelial thinning of the vaginal wall from 146 μm to 47 μm (mean, P < 0.001). Furthermore, epithelial glycogen accumulation and vascularity of the vaginal wall significantly decreased (43% and 23%, respectively) as compared with the control group (no intervention; n = 5). No significant differences were found for other outcome measures.ConclusionThis study established the ewe as a suitable large animal model for GSM. Furthermore, the similar relevant outcomes in humans and ewes hold great value for future translational research for the evaluation and optimization of different treatment modalities for GSM.