bluuebunny/crossref_metadata_2025_split huggingface dataset:
Similar Presynaptic Action Potential-Calcium Influx Coupling in Two Types of Large Mossy Fiber Terminals Innervating CA3 Pyramidal Cells and Hilar Mossy Cells
Authors: Marosi Endre Levente , Arszovszki Antónia , Brunner János , Szabadics János 
Published: January 2023

AbstractMorphologically similar axon boutons form synaptic contacts with diverse types of postsynaptic cells. However, it is less known to what extent the local axonal excitability, presynaptic action potentials (APs), and AP-evoked calcium influx contribute to the functional diversity of synapses and neuronal activity. This is particularly interesting in synapses that contact cell types that show only subtle cellular differences but fulfill completely different physiological functions. Here, we tested these questions in two synapses that are formed by rat hippocampal granule cells (GCs) onto hilar mossy cells (MCs) and CA3 pyramidal cells, which albeit share several morphologic and synaptic properties but contribute to distinct physiological functions. We were interested in the deterministic steps of the action potential-calcium ion influx coupling as these complex modules may underlie the functional segregation between and within the two cell types. Our systematic comparison using direct axonal recordings showed that AP shapes, Ca2+currents and their plasticity are indistinguishable in synapses onto these two cell types. These suggest that the complete module that couples granule cell activity to synaptic release is shared by hilar mossy cells and CA3 pyramidal cells. Thus, our findings present an outstanding example for the modular composition of distinct cell types, by which cells employ different components only for those functions that are deterministic for their specialized functions, while many of their main properties are shared.
Nerwica natręctw a kanoniczny konsens małżeński
Authors: Świaczny Seweryn 
Published: January 2023

One of the groups of psychic diseases that cause not only disorders of mind and will, but also the whole personality, are obsessions. Being under their influence the human being is unable to concentrate on the subject of marital consensus, he/she cannot estimate the value of harmony or his/her will is so weak that the person suffering from obsessions does not have the freedom of choice. When the force of obsessions comes to a high degree, they paralyze the person’s everyday life. This disease has such a big influence that the person suffering from it is unable to lead conjugal life as his/her thoughts are occupied by something else and he/she thinks neither about striving for mutual improvement nor about upbringing his/her offspring.
Hyperactivation of YAP/TAZ Drives Alterations in Mesangial Cells through Stabilization of N-Myc in Diabetic Nephropathy
Authors: Choi Seunghyeok , Hong Seon Pyo , Bae Jung Hyun , Suh Sang Heon , Bae Hosung , Kang Kyung Pyo , Lee Hyuek Jong , Koh Gou Young 
Published: January 2023

Significance Statement
Mesangial cells (MCs) in the kidney are essential to maintaining glomerular integrity, and their impairment leads to major glomerular diseases including diabetic nephropathy (DN). Although high blood glucose elicits abnormal alterations in MCs, the underlying mechanism is poorly understood. We show that YAP/TAZ are increased in MCs of patients with DN and two animal models of DN. High glucose directly induces activation of YAP/TAZ through the canonical Hippo pathway in cultured MCs. Hyperactivation of YAP/TAZ in mouse MCs recapitulates the hallmarks of DN. Activated YAP/TAZ bind and stabilize N-Myc, one of the Myc family. N-Myc stabilization leads to aberrant enhancement of its transcriptional activity and to MC impairments. Our findings shed light on how high blood glucose in diabetes mellitus leads to DN and support a rationale that lowering blood glucose in diabetes mellitus could delay DN pathogenesis.

Background
Mesangial cells (MCs) in the kidney are central to maintaining glomerular integrity, and their impairment leads to major glomerular diseases, including diabetic nephropathy (DN). Although high blood glucose elicits abnormal alterations in MCs, the underlying molecular mechanism is poorly understood.

Methods
Immunolocalization of YAP/TAZ and pathological features of PDGFRβ+ MCs were analyzed in the glomeruli of patients with DN, in Zucker diabetic fatty rats, and in Lats1/2

iΔPβ mice. RiboTag bulk-RNA sequencing and transcriptomic analysis of gene expression profiles of the isolated MCs from control and Lats1/2
iΔPβ mice were performed. Immunoprecipitation analysis and protein stability of N-Myc were performed by the standard protocols.

Results
YAP and TAZ, the final effectors of the Hippo pathway, are highly increased in MCs of patients with DN and in Zucker diabetic fatty rats. Moreover, high glucose directly induces activation of YAP/TAZ through the canonical Hippo pathway in cultured MCs. Hyperactivation of YAP/TAZ in mouse model MCs recapitulates the hallmarks of DN, including excessive proliferation of MCs and extracellular matrix deposition, endothelial cell impairment, glomerular sclerosis, albuminuria, and reduced glomerular filtration rate. Mechanistically, activated YAP/TAZ bind and stabilize N-Myc protein, one of the Myc family of oncogenes. N-Myc stabilization leads to aberrant enhancement of its transcriptional activity and eventually to MC impairments and DN pathogenesis.

Conclusions
Our findings shed light on how high blood glucose in diabetes mellitus leads to DN and support a rationale that lowering blood glucose in diabetes mellitus could delay DN pathogenesis.
Issues of Legal Qualification of Advertising and Propaganda of Narcotic Drugs
Authors: Kosyrev E. V. 
Published: January 2023

The paper examines the administrative responsibility for advertising and propaganda of narcotic drugs, established by Article 6.13 of the Administrative Code of the Russian Federation, the definitions of these categories are considered. The statistics of judges’ consideration of cases under this article are given. Based on the analysis of judicial practice, the forms by which advertising and propaganda of narcotic drugs are carried out are studied, and it is also concluded that it is the propaganda of narcotic drugs that is most often identified than their advertising.The issue of delineation of offenses related to advertising and propaganda of narcotic drugs is also being considered. The analysis of judicial practice allowed us to come to the conclusion that these concepts are not actually differentiated by law enforcement agencies, this happens, in particular, due to the fact that responsibility for these acts is established by one norm, while it is concluded that such an offense as advertising of narcotic drugs is more socially dangerous, since advertising can also be propaganda at the same time. As a result, this offense must be punished most severely.
The Role of Crafts in the Development of Women’s Entrepreneurship in Rural Areas
Authors: Bondyra Krzysztof , Dziekanowska Małgorzata , Herudziński Tomasz 
Published: January 2023

The aim of the article is to indicate the need for a diagnosis of socio-cultural conditions of running a craft business by women. Local handicraft, culinary traditions, etc. are also an important resource for the development of women’s entrepreneurship with a craft profile. The problems of the article include the ‘common set’ of two research areas: crafts and women’s entrepreneurship in rural areas. The focus of the paper will be on the issue of the functioning of crafts in rural areas based on an empirical analysis of the scale of functioning of craft enterprises run by women. Concurrently, the subject outlined in this way is related to other issues, such as counteracting depopulation of rural areas based on the activation of local entrepreneurship. The potential of women’s entrepreneurship development in rural areas should also be indicated, among others, by tightening cooperation between Country Housewives’ Associations (koła gospodyń wiejskich, KGWs) and crafts organisations.
The social effects of cooperation between crafts and KGWs will result in stimulation of entrepreneurship (especially female entrepreneurship) in rural areas, which will then contribute to rural development. These effects support the creation of new forms of small and medium entrepreneurship corresponding to social economy, which are defined as an element of creative economy. This will trigger the process of creating new jobs and may constitute an important mode of support for vocational education, increasing the chance for the local youth to smoothly enter the labour market. Likewise, the generation of local human and social capital resources cannot be overestimated. By mobilising and integrating key actors in the area, it will contribute to better management of local resources.
Genetically Associated Hypertrophic Cardiomyopathy Combined with Persistent Left Superior Vena Cava
Authors: Georgiev Antonio , Grueva Elena , Mitevski Goran , Nikolovski Robert , Janusevski Filip , Risteski Dejan 
Published: January 2023

Background: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy. An implantable cardioverter defibrillator (ICD) is an efficient way of preventing sudden cardiac death in these patients.
Aim: Diagnosis and treatment of genetically associated hypertrophic cardiomyopathy.
Case Report: We present a 28-year patient with a history of tachycardia, dizziness, transient chest pains, and anamnestic information on episodes of short-term loss of consciousness and fatigue. She has a positive family history of HCM and her uncle died young from sudden cardiac death (SCD). The electrocardiogram showed hypertrophy, which was confirmed with echocardiography and MRI. Genetic testing confirms PRKAG2 gene mutation. Holter24-hour ECG monitoring showed domination of sinus bradycardia after which it was recommended implantation of ICD. On implantation, persistent left superior vena cava (PLSVC) was discovered and the implantation side was changed. A bipolar Implantable Cardioverter Defibrillator was implanted.
Conclusion: When HCM is confirmed at a young age, genetically associated HCM should always be considered. Early recognition of hereditary hypertrophic cardiomyopathy can facilitate better disease management and follow-up even before symptoms appear.
Keywords: hypertrophic cardiomyopathy, PRKAG2 gene mutation, PLSVC, SCD, ICD.
An unusual lupus like malar rash pattern with hepatosplenomegaly as a presentation of gamma delta t cell lymphoma
Authors: Bani-Mustafa Ala’a Abdullah Hussein , Yousef Mustafa Magableh Ahmad , Bawa'neh Hisham Subhi Hussin , Alrosan Zaid Nu’man Abdel Latif 
Published: January 2023

About 12% of all lymphoid tumors worldwide are peripheral t cell lymphomas, which are uncommon subtypes of non-hodgkin lymphoma. they have a poor prognosis and are more common in populations and countries in asia. T cell lymphomas with gamma delta t cell receptors expressed in them are very rare (less than 1% of lymphoid neoplasms) and extremely aggressive; they originate from gamma delta t cells; a small subset of peripheral t cells with direct antigen recognition capability acting at the interface between innate and adaptive immunity .
Lymphoid tissue, skin, gastrointestinal tract, and the red pulp of the spleen are where gamma delta t lymphocytes tend to cocentrate, representing only 1-5% of the total circulating lymphocytes, but accounting for up to 30% of the entire t cell population.
In contrast to alpha beta t cells, gamma delta t lymphocytes develop from cd4/cd8 thymic precursors in the bone marrow and usually lack the major histocompatibility complex restriction.
These lymphocytes conduct as cytotoxic cells similar to natural killer cells in their activity as early effectors of innate, non-specific immune response and are capable of t cell receptor rearrangement as well as phagocytosis.
Hepatosplenic t cell lymphoma and primary cutanous gamma delta cell lymphoma are recognized as two different gamma delta t cell lymphoma entities.
A well characterized extranodal lymphoma, hepatosplenic t cell lymphoma has a disguised onset, secondary to intrasinusoidal infiltrationn of the spleen, liver, and bone marrow, has a rapidly progressive course, is poorly responsive to chemotherapy.
A panniculitis-like clinical picture with prominent epidermal involvement can be a presentation of primary cutaneous gamma delta t cell lymphoma.
In this case study , the authors will discuss a case of 19 year old male patient present with a lupus like malar rash and hepatosplenomegaly and who had been diagnosed with gamma delta t cell lymphoma.
Implementasi Nilai-Nilai Jihad dalam Kepemimpinan Pendidikan
Authors: Fahrudin Rudi , Herdianto Agus , Kaulika Syamel Massa , Zahra Zahra 
Published: January 2023

Jihad is a sensitive term especially for those who quite like the existence of Islam and its teachings due to limited knowledge. In fact, the term jihad has broad meaning, but it is often interpreted narrowly as war. The principal can play a major role in turning the connotation of jihad into beauty. To begin to change the connotation it needs to start from practicing the value of jihad in his profession. The principal is the engine driving an educational institution and the resources within it. To the teacher and staff, also to students or students.This discussion aims to explore the context of jihad which is implemented in the principal's leadership style. Data mining is done by library research. The results show that jihad can be implemented in the principal's leadership style which is a sincere and total performance. Jihad that leads to war is textual understanding what is used is the context of jihad which is the spirit of renewal. In the future, the term jihad should be understood in depth and provide information about true jihad without lies.
STUDI NASKAH TERHADAP TEKS TENTANG KRITIK HADIS- HADIS IMAM MAHDI DALAM GRUP WHATSAPP KAJIAN : BELAJAR HADIS YUK
Authors: Alawiah Neli 
Published: January 2023

This study aims to examine the text on the critique of the hadiths of Imam Mahdi presented in a study in a whatsapp group: Belajar Hadis Yuk. Studying hadith is a special study of hadith whose material is delivered virtually. The research method used is qualitative research. The data search technique in this study uses observation and documentation, the purpose of observation and documentation in this study is the delivery of material whatsapp group: Belajar Hadis Yuk entitled criticism of Imam Mahdi's hadiths. The data analysis technique of this research uses a manuscript study of the text presented in the study of hadith learning. The results of this study indicate that: Hadith study on whatsapp group Belajar Hadis Yuk talk about the Criticism of Hadiths Imam Mahdi has provided insights on group members who do not study hadith in a special institution. The study can be accessed virtually via google meet discussing the critique of the hadiths of Imam Mahdi.
Keywords: Critisism; Hadith; Imam Mahdi; Manuscript Study.
ANALISIS VARIABEL MAKRO EKONOMI TERHADAP PEMBIAYAAN BERMASALAH PADA BPRS DI INDONESIA PERIODE 2014-2021
Authors: Septiatin Aziz , Riduwansyah Riduwansyah , Krisdayanti Helisia 
Published: January 2023

In making investments, financing from Islamic banking is still the mainstay of various parties. Not all financing disbursed to the public are categorized as healthy, but some of them are financing that has poor quality or problems such as non-current financing, financing whose debtors do not meet the promised requirements, and the financing does not comply with the installment schedule. This study aims to analyze the effect of the BI Rate, Exchange Rate and Inflation on the level of non-performing financing (NPF) at Islamic Rural Banks for the period 2014-2021 per month. The method used in this research is descriptive with a quantitative approach and uses multiple linear regression analysis and hypothesis testing using the t test and F test which previously tested the classical assumptions first. The results showed that the BI Rate, exchange rate and inflation variables simultaneously had no effect on the NPF level. While partially the BI rate and inflation variables have no effect on the NPF while the exchange rate variable has a significant effect on the NPF.
Keyword : BI Rate, exchange rate, Inflation, NPF
Tradisi Mitoni Pada Masyarakat Katolik
Authors: Riani Eka , Nurfitriyana Nurfitriyana , Nugroho Nugroho 
Published: January 2023

This thesis is titled “MITONI TRADITION IN CATHOLIC COMMUNITY (Case Study in Harjowinangun Village, Belitang District, Ogan Komering Ulu Timur District)”. The background to this is that many Catholic communities still follow the biennial tradition with Genduren, specifically the biennial rite (mitoni). The Catholic community has abandoned the traditional ritual of bathing seven wells with roses, jasmine and ylang-ylang, changing clothes seven times. The form of the problem is as follows: is the Mitoni tradition in the Catholic community of Harjowinangun village?. What is the role of child prodigies in mitoni worship in Harjowinangun village?. The purpose of the study was to better understand mitoni tradition Catholic community of Harjowinangun and the role of child prodigies in the process of mitoni worship in Harjowinangun village. The result of this study is that the implementation of the mitoni tradition Catholic community in Harjowinangun village starts with the preparation, performing the gendurenan and mitoni cults and takes about an hour. Beginning with the opening rite, introduction to the priest, proclamation of repentance, opening prayer, proclamation of the word, Bible reading, homily, prayer, and after the Our Father, concluding with a prayer willing to end. After the mitoni service is over, the mitoni service participants immediately leave the room. Then everyone enters the dining room to taste the dishes that have been prepared by the host. After the meal, the Catholic community returned to their own homes.
YOUTUBE AS INSTRUCTIONAL MEDIA IN PROMOTING EFL INDONESIAN STUDENTS’ PRONUNCIATION
Authors: Suwastini Ni Komang Arie , Rastari Kadek Lelyana , Suarcaya Putu 
Published: January 2023

<p align="center"><strong>Abstract</strong></p><p class="abstrak">Pronunciation for Indonesian EFL students is tricky and challenging due to the different phonetic systems of the student's mother tongue and the target language. Integrating YouTube into English language learning could overcome these issues. The present study reviewed previous studies about the benefits of integrating YouTube as instructional media in promoting EFL students' pronunciation. This study was library research following George's (2008) model by selecting recent publications on the topic to summarize how YouTube videos affect students' English pronunciation and highlight a research gap that could be taken by future research. The review revealed that YouTube had benefitted students in aspects of pronunciation: stress, intonation, rhythm, voice quality, gestures, vowels, and consonants, although research on the application's use for improving students' rhythm is minimal despite the availability of relevant videos. This finding implies the need for more research on improving students' rhythm using YouTube video.</p><p class="abstrak"> </p><p><strong>Bahasa Indonesia Abstrak</strong></p><p><br />Pengucapan bahasa Inggris sangat rumit untuk pebelajar Indonesia karena perbedaan dalam sistem fonetik bahasa ibu dan bahasa target siswa. Integrasi video YouTube ke dalam pembelajaran bahasa Inggris dapat mengatasi masalah ini. Kajian ini mencermati hasil penelitian terkini mengenai integrasi video YouTube sebagai media pembelajaran untuk meningkatkan pelafalan bahasa Inggris siswa. Penelitian ini merupakan kajian pustaka menggunakan model dari George (2008), dengan melibatkan peneitian terkait untuk menghasilkan gambaran umum mengenai pengaruh video Youtube terhadap pelafalan siswa untuk menyoroti kesenjangan penelitian yang masih ada sehingga menjadi masukan untuk penelitian selanjutnya. Ditemukan bahwa Youtube meningkatkan pelafalan siswa dari tekanan, intonasi, ritme, kualitas suara, gestur, pelafalan suara vokal dan konsonan. Namun, penelitian yang menyoroti pemanfaatan Youtube untuk meningkatkan ritme dalam pelafan siswa masih terbatas, walaupun Youtube menyediakan banyak video yang relevan. Temuan ini berimplikasi pada perlunya penelitian lebih lanjut mengenai pemanfaatan video YouTube untuk mengembangkan ritme pelafalan bahasa Inggris siswa.</p>
Covid 19 Sebagai Force Majeure untuk Menunda Pelaksanaan Kontrak yang Termuat dalam Akta Notaris
Authors: Aditya Mahardhika Gilang 
Published: January 2023

Corona Virus Disease (Covid 19) has a significant impact on all aspects of human life. One of the aspects affected by Covid 19 is the business sector, especially in contract implementation. A Contract is an agreement made or agreed upon by the parties in writing. An agreement exists because of an act committed between one or more people against one or more people who bind themselves to each other. So that this event creates a legal relationship between the parties, which includes rights and obligations. In a contract, there is usually a clause or arrangement related to a forced condition or what is known as a force majeure (overmacht). The regulation relating to force majeure exists because to protect the debtor when in the execution of the contract contained in the notariil deed, the debtor in carrying out his obligations to the creditor occurs an event that is beyond the power of the party concerned. Force majeure can be categorized as earthquakes, floods, landslides, wars, fires, military coups, embargoes, epidemics, and so on. During the corona pandemic that is currently sweeping all parts of the world certainly has an impact on the implementation of a contract. Therefore, further explanation is needed regarding the impact of Covid 19 as force majeure to delay implementation of the contracts contained in the notarial needed.
KEYWORDS: Covid 19, Contract, Force Majeure, Notarial Deed.