bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unconjugated bilirubin induces neuro-inflammation in an induced pluripotent stem cell-derived cortical organoid model of Crigler Najjar Syndrome
Authors: Pranty Abida Islam , Wruck Wasco , Adjaye James 
Published: July 2023

AbstractBilirubin-induced neurological damage (BIND), which is also known as Kernicterus, occurs as a consequence of defects in the bilirubin conjugation machinery, thus resulting in unconjugated bilirubin (UCB) to cross the blood–brain barrier (BBB) and accumulation. Severe hyperbilirubinemia can be caused by a mutation within theUGT1A1encoding gene. This mutation has a direct contribution towards bilirubin conjugation leading to Kernicterus as a symptom of Crigler Najjar Syndromes (CNS1, CNS2) and Gilbert syndrome, which results in permanent neurological sequelae. In this comparative study, we used human induced pluripotent stem cells (hiPSCs)-derived 3D-brain organoids to model BINDin vitroand unveil the molecular basis of the detrimental effects of UCB in the developing human brain. hiPSC-derived from healthy and CNS patients were differentiated into day-20 brain organoids, these were then stimulated with 200nM UCB. Analyses at 24- and 72-hrs post-treatment point at UCB-induced neuro-inflammation in both cell lines. Transcriptome and associated KEGG and Gene Ontology analyses unveiled activation of distinct inflammatory pathways such as cytokine-cytokine receptor interaction, MAPK signaling, calcium signaling, NFκB activation. Furthermore, both mRNA expression and secretome analysis confirmed an upregulation of pro-inflammatory cytokines such as IL6 and IL8 upon UCB stimulation. In summary, this novel study has provided insights into how a human iPSC-derived 3D-brain organoid model can serve as a prospective platform for studying the etiology of BIND-Kernicterus.
Always-on business: integrating business continuity and business resilience
Authors: Bajgorić Nijaz 
Published: July 2023

PurposeThe paper aims to present a framework for integrating the concepts of business continuity and business resilience with the aim of developing a concept of always-on business.Design/methodology/approachLiterature review, conceptual and case-based.FindingsA conceptual model for integrated “always-on business” solution based on continuous comouting technologies, business continuity, disaster recovery, IT/business resilience and several organational frameworks.Originality/valuePresented framework can be used for integrating business continuity and business resilience in modern digital age; and transforming business systems into “always-on business”.
Artificial intelligence in supply chain decision-making: an environmental, social, and governance triggering and technological inhibiting protocol
Authors: Hao Xinyue , Demir Emrah 
Published: July 2023

Purpose
Decision-making, reinforced by artificial intelligence (AI), is predicted to become potent tool within the domain of supply chain management. Considering the importance of this subject, the purpose of this study is to explore the triggers and technological inhibitors affecting the adoption of AI. This study also aims to identify three-dimensional triggers, notably those linked to environmental, social, and governance (ESG), as well as technological inhibitors.

Design/methodology/approach
Drawing upon a six-step systematic review following the preferred reporting items for systematic reviews and meta analysis (PRISMA) guidelines, a broad range of journal publications was recognized, with a thematic analysis under the lens of the ESG framework, offering a unique perspective on factors triggering and inhibiting AI adoption in the supply chain.

Findings
In the environmental dimension, triggers include product waste reduction and greenhouse gas emissions reduction, highlighting the potential of AI in promoting sustainability and environmental responsibility. In the social dimension, triggers encompass product security and quality, as well as social well-being, indicating how AI can contribute to ensuring safe and high-quality products and enhancing societal welfare. In the governance dimension, triggers involve agile and lean practices, cost reduction, sustainable supplier selection, circular economy initiatives, supply chain risk management, knowledge sharing and the synergy between supply and demand. The inhibitors in the technological category present challenges, encompassing the lack of regulations and rules, data security and privacy concerns, responsible and ethical AI considerations, performance and ethical assessment difficulties, poor data quality, group bias and the need to achieve synergy between AI and human decision-makers.

Research limitations/implications
Despite the use of PRISMA guidelines to ensure a comprehensive search and screening process, it is possible that some relevant studies in other databases and industry reports may have been missed. In light of this, the selected studies may not have fully captured the diversity of triggers and technological inhibitors. The extraction of themes from the selected papers is subjective in nature and relies on the interpretation of researchers, which may introduce bias.

Originality/value
The research contributes to the field by conducting a comprehensive analysis of the diverse factors that trigger or inhibit AI adoption, providing valuable insights into their impact. By incorporating the ESG protocol, the study offers a holistic evaluation of the dimensions associated with AI adoption in the supply chain, presenting valuable implications for both industry professionals and researchers. The originality lies in its in-depth examination of the multifaceted aspects of AI adoption, making it a valuable resource for advancing knowledge in this area.
The impact of country-level sustainability and digitalization on the performance: sharing economy dashboard
Authors: Pérez-Pérez Cristina , Benito-Osorio Diana , Jimenez Alfredo , Bayraktar Secil 
Published: July 2023

PurposeThe Sharing Economy (SE) has turned around the concepts of ownership and access, promoting not only an alternative consumption method, but also a more sustainable one. Using digital platforms, this phenomenon expects to achieve a better use of the idle capacity of resources, promote meaningful and trusting communities and contribute to reducing the environmental harm. The huge increase of popularity of this model has lined up with the Sustainable Development Goals proclamation, and the commitment from governments with the search for more sustainable models. This study analyzes the relationship of the SE with sustainability in general, and the Sustainable Development Goals in specific.Design/methodology/approachThrough the analysis of the action plans proposed by governments and the expected contributions of sharing platforms to sustainability, the authors analyze the improvements and assistance that the Sharing Economy could offer to countries.FindingsThe main findings suggest that the SE can assist countries to achieve their sustainability goals and to further advance towards a more sustainable consumption and living model in order to fulfill the Sustainable Development Goals.Originality/valueAlthough this topic is still to be further developed, the SE seems to be fulfilling the expectations as the path towards sustainability.
Focal deblending: Marine data processing experiences
Authors: Kontakis Apostolos , Verschuur Dirk Jacob 
Published: July 2023

AbstractIn contrast to conventional acquisition practices, simultaneous source acquisition allows for overlapping wavefields to be recorded. Relaxing the shot schedule in this manner has certain advantages, such as allowing for faster acquisition and/or denser shot sampling. This flexibility usually comes at the cost of an extra step in the processing workflow, where the wavefields are deblended, that is, separated. An inversion‐type algorithm for deblending, based on the focal transform, is investigated. The focal transform uses an approximate velocity model to focus seismic data. The combination of focusing with sparsity constraints is used to suppress blending noise in the deblended wavefield.The focal transform can be defined in different ways to better match the spatial sampling of different types of marine surveys. To avoid solving a large inverse problem, involving a large part of the survey simultaneously, the input data can be split into sub‐sets that are processed independently. We discuss the formation of such sub‐sets for ocean bottom node and streamer‐type acquisitions. Two deblending experiments are then carried out. The first is on numerically blended ocean bottom node field data. The second is on field‐blended towed streamer data with a challenging signal overlap. The latter experiment is repeated using curvelet‐based deblending for comparison purposes, showing the virtues of the focal deblending process. Several challenges of basing deblending around the focal transform are discussed as well as some suggestions for improved implementations.
Age estimation biases based on body size: the differential impacts of soft tissue on skeletal ageing
Authors: Merritt Catherine E. 
Published: July 2023

AbstractThe aim of this research project is to explore the differential impacts of soft tissues on skeletal ageing and apply these findings to skeletal age estimation methods. Computed tomography (CT) scans of 412 size‐selected individuals from Ontario, Canada, were assessed using an adapted pubic symphysis age estimation method. Individuals ranged from 20 to 79 years of age (mean = 49.46 years), with 208 males and 204 females. Almost 80 per cent of the sample was assigned to the correct age phase; those not correctly aged followed a similar pattern. Individuals with higher body mass, body mass index (BMI), circumference, and total fat area were over‐aged and those with lower body mass, BMI, circumference, and total fat area were under‐aged. High amounts of adipose tissue led to increased skeletal degeneration, but high amounts of muscle tissue did not have a protective effect. Skeletal elements were not reliable proxies for body mass; however, other morphological features may help identify individuals with high body mass from skeletal remains.
The impact of access to prenatal health insurance for noncitizen women on child health
Authors: Hwang Grace 
Published: July 2023

AbstractObjectiveTo estimate the effects of prenatal public health insurance targeting noncitizens on the health of U.S.‐born children of noncitizen mothers beyond birth outcomes.Data Sources and Study SettingThis paper uses the restricted version of the 1998–2014 National Health Interview Survey with state‐level geographic identifiers.Study DesignThe empirical strategy compares outcomes in states that adopted the Children's Health Insurance Plan (CHIP) Unborn Child Option with states that never adopted or adopted it at different times, controlling for differences in the pre‐treatment period. I use a flexible event‐study analysis to quantify the effects of the Unborn Child Option on noncitizen women's health insurance coverage, health care utilization, and their children's health.Data Collection/Extraction MethodsAll data are derived from pre‐existing sources.Principal FindingsThe study finds that the impact of the Unborn Child Option is a 4.7%‐point increase in public health insurance coverage (p < 0.01) and 0.48 more doctor's office visits (p < 0.1) annually among noncitizens of childbearing ages. Subsequently, the reform leads to a 7%‐point rise in the rate of parents reporting their 4–6‐year‐old children are in “excellent” or “very good” health (p < 0.01). While no improvements are evident at birth and at younger ages, observed health improvements begin to appear by preschool age.ConclusionsThe study contributes to the literature by providing evidence that certain benefits of in‐utero public health insurance targeting noncitizens may appear several years after birth, specifically around preschool age.
Geriatric Depression Scale predicts mortality in elderly patients on chronic hemodialysis
Authors: Bossola Maurizio , Pepe Gilda , Antocicco Emanuela , Illuminati Camilla , Di Stasio Enrico 
Published: July 2023

AbstractIntroductionThe aim of this study was to determine if the Geriatric Depression Scale (GDS) was predictor of mortality in elderly patients on chronic hemodialysis (HD).MethodsA total of 140 HD patients ≥65 years were studied. Symptoms of depression were assessed through GDS and cognitive function through the Mini Mental State Examination (MMSE). GDS scores 0–9 are considered normal (Group 1); scores of 10–20 (Group 2) and 21–30 (Group 3) indicate mild and severe depression.ResultsMedian GDS was 13 (11–15): 54 patients in Group 1, 49 in Group 2, and 37 in Group 3. After a follow‐up of 58.85 ± 38.8 months, 94 patients died and 46 were alive. Kaplan–Meier survival was significantly lower in patients of Groups 2 and 3 than in Group 1 (log‐rank χ2: 101.9; DF: 2; p < 0.0001). According to Cox regression analysis, mortality was associated with age and GDS, and inversely associated with MMSE and Kt/V.ConclusionGDS predicts mortality in elderly HD patients.
Predisposing factors for advanced liver fibrosis in patients with sickle cell disease
Authors: Manganas Konstantinos , Delicou Sophia , Xydaki Aikaterini , Kourakli Alexandra , Evliati Loukia , Vlachaki Efthymia , Klironomos Evangelos , Diamantidis Michail , Lafiatis Ioannis , Kattamis Antonios , Koskinas John 
Published: July 2023

SummarySickle cell disease (SCD) is one of the most common monogenic disorders worldwide and liver complications are common in this group of patients. Our study aims to highlight the prevalence of chronic liver complications and the main predisposing factors for advanced liver fibrosis in SCD patients. For this purpose, 219 patients from eight Thalassemia and Sickle Cell Units across Greece enrolled in our study and history of liver related disease complications was recorded, as well as a full laboratory and imaging analysis concerning their liver function. 13.6% of the patients had advanced liver fibrosis. The presence of liver fibrosis was significantly correlated with advanced age, male gender, cholelithiasis and higher LDH, γ‐GT, INR, direct and indirect bilirubin levels. These patients had exhibited significantly more episodes of liver crises and acute intrahepatic cholestasis. No correlation was observed with right heart failure or previous viral hepatitis. Patients with advanced liver fibrosis were receiving a more intensive transfusion therapy for a longer period of time and had higher Liver Iron Concentration levels. Our study shows that liver complications and cirrhosis is a significant cause of morbidity in patients with SCD and it is primarily associated with intravascular hemolysis and vaso‐occlusive phenomena and secondarily with iron overload.
Do Obligations Follow the Mind or Body?
Authors: Protzko John , Tobia Kevin , Strohminger Nina , Schooler Jonathan W. 
Published: July 2023

AbstractDo you persist as the same person over time because you keep the same mind or because you keep the same body? Philosophers have long investigated this question of personal identity with thought experiments. Cognitive scientists have joined this tradition by assessing lay intuitions about those cases. Much of this work has focused on judgments of identity continuity. But identity also has practical significance: obligations are tagged to one's identity over time. Understanding how someone persists as the same person over time could provide insight into how and why moral and legal obligations persist. In this paper, we investigate judgments of obligations in hypothetical cases where a person's mind and body diverge (e.g., brain transplant cases). We find a striking pattern of results: In assigning obligations in these identity test cases, people are divided among three groups: “body‐followers,” “mind‐followers,” and “splitters”—people who say that the obligation is split between the mind and the body. Across studies, responses are predicted by a variety of factors, including mind/body dualism, essentialism, education, and professional training. When we give this task to professional lawyers, accountants, and bankers, we find they are more inclined to rely on bodily continuity in tracking obligations. These findings reveal not only the heterogeneity of intuitions about identity but how these intuitions relate to the legal standing of an individual's obligations.
Immune‐mediated encephalitis
Authors: Rossor Thomas , Lim Ming 
Published: July 2023

AbstractA neurological deterioration in a child presents a significant worry to the family and often a diagnostic challenge to the clinician. A dysregulated immune response is implicated in a wide and growing spectrum of neurological conditions. In this review we consider the current paradigms in which immune‐mediated encephalopathies are considered; the development of paediatric specific diagnostic criteria that facilitate early consideration and treatment of immune‐mediated conditions and the limitations and potential developments in diagnostic testing. We consider the expanding phenotype of myelin oligodendrocyte glycoprotein antibody, the spectrum of virus‐associated encephalopathy syndromes, and the strategies that have been employed to build an evidence base for the management of these rare conditions. Looking forward we explore the potential for advanced molecular investigations to improve our understanding of immune‐mediated encephalitides and guide future treatment strategies.

Recently characterized immune‐mediated central nervous system disorders include new antibodies causing previously recognized phenotypes.
Aggregation of conditions with similar clinical triggers, and characterization of unique imaging features in virus‐associated encephalopathy syndromes.
Immune treatment iscurrently guided by meta‐analysis of individualized patient data and/or multi‐national consensus.
Associations between caregiver burden and care receivers' sharing ratio of household tasks among spousal caregivers
Authors: Otobe Yuhei , Kimura Yosuke , Terao Yusuke , Suzuki Mizue , Tanaka Shu , Kojima Iwao , Koyama Shingo , Kusumi Haruhiko , Yamada Minoru 
Published: July 2023

AimWe assessed care receivers' sharing ratios of household tasks before they required care and investigated their relationship with caregiver burden.MethodsA cross‐sectional, online survey was completed by 272 spousal caregivers in Japan. Caregiver burden was assessed using the Zarit Burden Interview. Low and moderate‐to‐high caregiver burdens were defined as those with scores ≤40 and ≥41, respectively. Additionally, caregiver responses to, “How much did your partner contribute to household tasks before the onset of their condition that needed care?” were scored on a 10‐point Likert scale ranging from 1 to 10. We defined answers that scored 1–4 as a low sharing ratio and those that scored 5–10 as a high sharing ratio of household tasks of care receivers before developing a condition that required care.ResultsAmong the husband and wife caregivers, moderate‐to‐high caregiver burden in 33 (25.0%) and 48 (34.3%) caregivers, respectively. Multivariate logistic regression analysis showed that among the husband caregivers, the high sharing ratio of household tasks of their wives before developing a condition that required care was significantly associated with their caregiver burden (OR 4.55, 95% CI 1.20–17.27); however, no such association was observed among the wife caregivers (OR 0.85, 95% CI 0.37–2.29).ConclusionsAmong husband, but not wife caregivers, the high sharing ratio of household tasks of their wives before they required care was significantly associated with their caregiver burden. Geriatr Gerontol Int 2023; 23: 616–621.
A modified nonsurgical treatment of keloids: Cocktail therapy
Authors: Liu Yue , Cao Yuchen , Su Xueshang , Li Shasha , Dou Maomei , Qu Chunan , Hu Jintian , Wang Lianzhao 
Published: July 2023

AbstractBackgroundThe high recurrence rate after nonsurgical treatment of keloid is a major challenge for clinicians. Although there are many existing treatment options, how to optimize and upgrade the existing options and make a reasonable combination of utilization is our concern. The aim of this study is to provide a comprehensive non‐surgical treatment for keloid—cocktail therapy.MethodsAccording to the different changes of keloid with treatment, the treatment was divided into four stages, and different treatment schemes were adopted for each stage. The incidence of side effects of keloid at each stage and the effective rate and cure rate 16 months after the end of treatment were analyzed.ResultsAll patients completed this study on time, and were followed up 16 months after the end of treatment, the treatment effective rate was 100%, and the cure rate was up to 92.8%.ConclusionCocktail therapy can achieve a higher cure rate of keloid, and is worthy of clinical promotion.
Balancing immunosuppression in pediatric liver transplantation: Playing the long game
Authors: Antala Swati , DiNorcia Joseph , Bucuvalas John 
Published: July 2023

AbstractThe overarching goal in the care of pediatric liver transplant recipients is to optimize allograft and patient health. Balancing immunosuppression to maintain allograft health while avoiding medication side effects is essential for long‐term survival and optimal quality of life in pediatric liver transplant recipients. Utilizing precision medicine to personalize immunosuppression, which includes minimization and withdrawal, is core to this effort. The unique anatomy and physiology of the liver make it more tolerant to immune‐mediated injury and a more favorable organ for immunosuppression minimization and withdrawal. However, several challenges exist. Standard biochemical values and histologic features may not reliably predict allograft health after a reduction in immunosuppression. Additionally, biochemical values alone do not reliably identify which patients can successfully develop operational tolerance, as there may be occult allograft injury despite normal liver enzymes. Finally, the durability of tolerance after successful reduction in immunosuppression remains uncertain over time. Innovative tools show promise in circumventing these challenges, but more research is needed to determine actual clinical utility. While immunosuppression‐free transplant may not be a current reality for most pediatric liver transplant recipients, strategies to safely minimize immunosuppression without compromising allograft health are within reach. Each liver allograft and recipient pair requires a different degree of immune modulation, and through a structured process of minimization and withdrawal, immunosuppression can indeed be tailored in a precise, personalized way to optimize outcomes. This review focuses on the progress that has been made to individualize immunosuppression in pediatric liver transplantation to ensure optimal allograft and recipient health.
The revolving door in UK government departments: A configurational analysis
Authors: Andrews Rhys , Beynon Malcolm J. 
Published: July 2023

AbstractThe “revolving door” between those at the top of public and private organizations has given rise to questions about the “pull” and “push” factors influencing public servants' switching into lucrative posts with companies they previously regulated. In this study, we investigate the departmental attributes associated with the movement of senior British civil servants into potentially controversial corporate jobs. To do so, we develop a configurational analysis of revolving door activity in UK government departments for 2015–2018 using panel‐based fuzzy‐set qualitative comparative analysis (fsQCA). We identify a series of alternative departmental conditions' based pathways for taking up, or not taking up, a role in the private sector. In particular, more prestigious departments with high levels of pay and low levels of agencification are associated with revolving door activity, while departments with low levels of pay, high levels of agencification, and low levels of capital procurement tend to be associated with an absence of such activity.