bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact on cardioprotective effect of Psidium guajava leaves extract in streptozotocin-induced Wistar mice with molecular in silico analysis
Authors: Manikandan Ramasamy , Balamuralikrishnan Balasubramanian , Boro Arthi , Karthika Pushparaj , Arun Meyyazhagan , Velayuthaprabhu Shanmugam , Malaisamy Arunkumar , Lakshminarayanan Rengarajan Rengasamy , Vijaya Anand Arumugam 
Published: April 2023

Cardiovascular disease (CVD) and its complications have been regarded as the leading cause of morbidity and mortality. The drugs available in the market are effective to treat CVD, but with many adverse reactions. Nowadays, herbal products are the attention of researchers because of their less adverse effects. In this study, the cardioprotective effects of ethanolic leaves extract of Psidium guajava Linn. (Guava) (P. guajava) were evaluated in streptozotocin (STZ)-treated animal models. Mice acquired for the study were divided into five groups, each consisting of six mice. The toxin-induced mice were treated with the ethanolic leaves extract of P. guajava (300 mg/kg body weight [b.w.]). The results were compared to the standard drug (glibenclamide)-treated mice (3 mg/kg b.w.). The following parameters were considered for further investigations: creatine kinase-muscle brain (CK-MB), creatine kinase (CK), troponin, lysosomal, and mitochondrial enzymes. Then the docking study was accomplished. The levels of cardiac marker enzymes and lysosomal enzymes increased significantly in the toxin-induced mice, while the level of mitochondrial enzyme decreased significantly. During treatment with the ethanolic leaves extract of P. guajava, the levels of all parameters were notably reversed to normal range (P < 0.05). Further, in docking analysis, the interaction of compounds, such as alpha-terpineol, cyclopentanecarboxamide, guaiol (a sesquiterpenoid alcohol), 1H-cyclopropanaphthalene, tetracyclotridecan-9-ol, dormin/abscisic acid, and epiglobulol, with the respective protein molecules, evidenced the cardioprotective effect of P. guajava leaves. Hence, it was concluded that the ethanolic leaves extract of P. guajava leaves have a cardioprotective effect.
TRABLUSGARP SAVAŞI’NDA ÇANAKKALE BOĞAZI’NIN MAYINLANMASI
Authors: SEYHAN Enes 
Published: April 2023

İtalya, milli birliğini tamamladıktan sonra diğer Avrupalı büyük devletler gibi hızla sömürgecilik politikası izlemiştir. Bu politika doğrultusunda da Akdeniz havzasında önce Tunus’a yönelmiş ancak Fransa’nın Tunus’u işgali ile Trablusgarp’ta nüfuz sağlama girişimlerinde bulunmuştur. İtalya, Trablusgarp’ı işgal etmeden önce bölgede işgali kolaylaştırabilmek maksadı ile siyasal, sosyal ve ekonomik birçok girişimde bulunduktan sonra Avrupalı büyük devletler ile de gizli anlaşmalar yapıp, onların da onayını aldıktan sonra Osmanlı Devleti’ne 29 Eylül 1911’de savaş açmışlardır.
İtalya’daki bazı yöneticiler, bu savaş için askeri bir gezinti havasında geçeceği şeklinde yorumlar yapmışlardı. Ancak İtalyan ordusu, gönüllü olarak bölgeye giden Türk subaylarının eğitim verip, organize ettiği yerli halkın direnişi karşısında çıkmaza girmiştir. Zira İtalyan askeri birlikleri şehirlerin kıyı bölgelerini işgal etmiş olsalar da yerli halkın direnişi karşısında şehirlerin iç taraflarına girmeyi bir türlü başaramamışlardır. Bu durum İtalyan ekonomisi üzerinde büyük krizlere yol açarken, İtalyan askerleri açısından da moral ve motivasyonlarının çökmesine neden olmuştur.
Bu nedenle İtalya, Osmanlı Devleti’ni barış masasına oturmak zorunda bırakmak için savaşı Akdeniz’e ve Ege’ye yaymaya karar vermiştir. Bu karar doğrultusunda da 18 Nisan 1912’de Çanakkale Boğazı’na saldırmışlardır. Bu makalede, İtalyan savaş gemilerinin Çanakkale Boğazı’nı geçme girişimlerine karşın, Osmanlı Devleti’nin almış olduğu savunma tedbirlerinden boğazın mayınlanma faaliyetleri incelenmiştir.
Obstetric outcome of antenatal mother with history of spontaneous abortion attending a tertiary care hospital in Puducherry
Authors: G. Vijayalakshmi , Nirmala Jaget , G. Sindhuja Sekar , R. Priyanka 
Published: April 2023

Background: The pregnancy time is critical for both the mother’s and the baby’s health. The most common unfavourable pregnancy outcome is spontaneous abortion. Spontaneous pregnancy loss is a surprisingly common event, with roughly 15% of all clinically diagnosed pregnancies ending in pregnancy failure. Couples who suffer from frequent miscarriages may find it difficult to cope physically and emotionally. This study was planned to evaluate the association of preterm delivery, low birth weight, IUGR, recurrence of abortion, still birth, IUD, PROM, or any other adverse outcome in patients with history of previous spontaneous abortions. Objectives were to look for association between previous spontaneous abortion and preterm delivery, low birth weight, IUGR, recurrence of abortion, stillbirth, IUD, PROM and other complications in subsequent pregnancies.
Methods: This was a prospective observational study done with 150 samples. The information such as demographic data of the antenatal women, clinical history, past obstetrics history, clinical examination, laboratory investigations and outcome of present pregnancy were collected and evaluated.
Results: Maternal complications such as UTI (4.6%), Infection and fever (5.3%), PROM (2.7%), PPH (4%), hyperemesis 4%, PPROM 2.7% were observed. In study population, 60% of the foetus were in cephalic position, 19% in breech presentation and 21% in shoulder presentation. 29% of the women had preterm delivery, 34% were delivered by LSCS and 6% had spontaneous abortions. Low birth weight babies delivered in 25% cases. Foetal distress was observed in 15%, FGR in 9%, still birth in 3% and IUD in 1%.
Conclusions: Women with previous spontaneous abortion are associated with a higher incidence of preterm delivery, cesarean section rate, neonatal low birth weight, fetal distress and high possibility of infection. Therefore, patients with previous spontaneous miscarriage represent a high-risk population for obstetric complication and close surveillance during the antenatal period is required.
Risk of obstructive sleep apnea in pregnant females in different trimester
Authors: Devi Sheetal , Kashyap Neha 
Published: April 2023

Background: Obstructive Sleep Apnea (OSA) is a common sleep-related breathing disorder, is characterized by recurrent collapse or blockage of the pharynx during sleep that causes intermittent cessation of airflow and a hallmark snoring gasping pattern. When OSA occurs in pregnancy, it is independently associated with increased risk of gestational hypertension, preeclampsia, gestational diabetes and possibly fetal growth restriction and other adverse neonatal outcomes. In particular, OSA affects sleep quality and duration of sleep in pregnant women. The aim was to study the risk of Obstructive Sleep Apnea in pregnant females in different trimester.
Methods: The study consists of a non-experimental, quantitative and cross sectional research design. A total of 60 pregnant females were included in the study and conducted at maternity clinic.
Results: By analyzing data we found that females in 3rd trimester shows symptoms of compromised breathing and thus are at high risk of developing OSA followed by 2nd trimester.
Conclusions: Our study shows that breathing limitation starts from 2nd trimester onwards, so, we conclude that starting breathing exercises early in antenatal period would be beneficial for the expecting mothers. The study concludes that there is high risk of obstructive sleep apnea in 3rd trimester of the pregnancy.
Evaluating association between thrombocytopenia and hypertension in pregnancy and its fetomaternal outcome
Authors: Alisha Gupta  , Vandana Dhama  , Shakun Singh  , Rachna Chaudhary  
Published: April 2023

Background: Hypertension in pregnancy is common complication of pregnancy with incidence 5-15% and associated with maternal and perinatal mortality and morbidity. Platelet count is most simple, rapid and economical method of prediction of pregnancy induced hypertension. The aim and objective of study was to corelate with severity of thrombocytopenia and its association with fetal and maternal outcome.
Methods: This study was a case control study and was conducted in department of obsterics and gynecology, SVBP hospital attached to LLRM medical college, Meerut, from October 2020 To June 2022. Total number of 100 pregnant females out of which 50 pregnant females with hypertension as cases and 50 pregnant females without hypertension as control were included in study. Observations were tabulated, analysed and conclusions were drawn.
Results: Out of 50 cases 43 patients developed preeclampsia thus giving incidence of 43 % and out of which 21 patients had mild thrombocytopenia,13 moderate thrombocytopenia and 4 severe thrombocytopenia. The mean age amongst cases was 26.73±5.19SD and the mean age amongst control was 28.09±4.83. There was very high significant relationship between the degree of thrombocytopenia with severity of hypertension during pregnancy (at p <0.01). 24% fetuses had preterm birth, 8% had fetal growth restriction, 2% were IUD and 2% mortality. 2% of mothers had DIC,8% had post-partum hemorrhage, 6% had abruption ,4% had pulmonary edema and 6% mortality.
Conclusions: Thrombocytopenia is most common and can be life threatening complication of pregnancy induced hypertension. Therefore, platelet count can be used as an early, easy, simple, most economical and rapid test to assess severity of preeclampsia and to prevent its progression to eclampsia, HELLP syndrome and DIC.
Audit of peripartum hysterectomies at an Indian tertiary care centre: a 12-year review
Authors: Sandhya Gadre  , Chaudhary Gunjan 
Published: April 2023

Peripartum hysterectomy is performed in critical conditions like major obstetric haemorrhage, abnormally-invasive placenta, rupture uterus. In developing countries incidence is 0.2–5/1000 deliveries. It can also be done as non-emergent surgeries for suspected cases by pre-planning. If high-risk patients are identified, timely intervention done, yields better outcome. Data of peripartum hysterectomy patients during last 12 years collected. Demographic details, menstrual-obstetric history, high-risk factors, previous and current delivery details, postpartum haemorrhage, indication, operative details of peripartum-hysterectomy, maternal-perinatal outcome, blood loss, anaesthesia records, length of ICU and hospital stay quantity of blood and products transfused analysed. 18 cases of peripartum hysterectomy with incidence of 2.76 per 1000 deliveries noted. 14-emergency, 4-electively done. In current pregnancy 13 had caesarean deliveries, 5 had vaginal deliveries, all required emergency hysterectomy. Majority were 26-30 years, 83% multiparous. 11 required emergency hysterectomy. 27.77% were due to atonic PPH and 22.22% placenta accreta spectrum. Mean anaesthesia duration, ICU stay, mean blood loss, units of blood and products was more in emergency group. Maternal and perinatal outcomes were favourable in elective group. Keeping high index of suspicion for accrete, identifying risk factors for atonic PPH, managing proactively, results in favourable maternal-perinatal outcome.
Mullerian duct cyst mimicking cervical elongation
Authors: Navya S. Joy  , Adaline Thangam T. F.  , Dev Minnu , Rini Francis  
Published: April 2023

Diagnosis of Mullerian duct cyst is determined by histopathological examination. Describe a case of a mass descending per vaginum in a 28-year-old lady that was originally misdiagnosed as an elongation of the cervix's anterior lip. Under anaesthesia, carried out surgical intervention that included complete excision of the mass via a vaginal route. Pathology result confirmed a benign Mullerian cyst histologically bordered by a single layer of ciliated columnar epithelial cells.
Vaginal birth after multiple caesarean section: a case report from India
Authors: Shamrao Ramji Wakode  , Sakshi Pramod Sharma  
Published: April 2023

Lower segment caesarean sections increase the possibility of maternal morbidity. Hence, since last few decades, initiative for trial of labor after caesarean delivery is being encouraged in selected cases. Accordingly, a 23-year-old fifth gravida, who had a history of previous three lower segment caesarean sections and one vaginal birth approached for delivery service and plan for her vaginal delivery was made after thorough examination and evaluation. A live female child of 3100 grams was delivered following episiotomy. In post-partum period, it was observed that uterus was involuted on abdominal examination and uterine contours were regular in ultrasonography. As the evidences for practice of vaginal delivery in women who underwent 2 or more previous LSCS are still fewer, this report intends to highlight the possibility of successful vaginal birth after multiple caesarean sections.
Long-term results of a post-partum bilateral Garden 4 femoral neck fracture in a young woman with transient osteoporosis treated with closed reduction and internal fixation
Authors: Bennani Mourad , Mouad Guenbdar  , Taoufik Cherrad  , Hassan Zejjari  , Hicham Bousbaa  , Jamal Louaste  , Larbi Amhajji  
Published: April 2023

Bilateral femoral neck fractures are very rare conditions. In our knowledge, only five cases were reported of bilateral acute femoral neck fracture secondary to transient osteoporosis. The present case is the first with a long-term follow up after treatment with closed reduction and internal fixation. A 32-year-old women was admitted to the emergency orthopedic clinic due to severe pain in both hips and an inability to walk one-day post-partum. Clinical examination revealed bilateral externally rotated legs and X-ray showed bilateral Garden 4 displaced subcapital fracture of the neck of the femur. The patient was operated on urgently by closed reduction and internal fixation. Osteoporosis was found in the measurements of bone mineral density and bisphosphonate with vitamin D medication was started. 6 years after surgery the patient can carry out her daily activities without limitation. His Harris hip score was 97 points/right and 95 points/left; and the X-ray was normal regarding osteoarthritis and avascular necrosis. Internal fixation should be the primary choice for the treatment of a bilateral femoral neck fractures with a high degree of displacement in young adults even with reversible poor bone quality condition such transient osteoporosis.
Evaluation of mandibular angle fractures in patients with maxillofacial injuries, in and around Indore- A retrospective and prospective study
Authors: Singhal Divya , Mitra Geeti. V. , Motiwale Tejas , Agrawal Nikit 
Published: April 2023

: Mandibular angle fracture is a common type of maxillofacial injury that can lead to significant morbidity if not managed properly. The management of mandibular angle fracture depends on various factors such as the severity of the injury, associated injuries, patient's age and overall health, and availability of resources. The purpose of this study is to evaluate the incidence, etiology, management, and outcomes of mandibular angle fracture in patients with maxillofacial injuries in and around Indore, using a combined retrospective and prospective approach.: A combined retrospective and prospective study was conducted at a tertiary care hospital in and around Indore. Data were collected on patient demographics, injury characteristics, diagnostic evaluation, treatment, and outcomes. A total of 1510 patients with maxillofacial injuries were included in the study, out of which 114 patients had mandibular angle fractures. The incidence of mandibular angle fracture in our study population was 19%. The majority of the patients with mandibular angle fracture were males (80.9%) and in the age group of 21-40 years (56.1%). The most common cause of mandibular angle fracture was road traffic accidents (77.7%), followed by assault (17.7%). The most common associated injuries were fractures of para symphysis (63.6%) followed by fractures of the condyle (25.3%). The follow-up of patients with mandibular angle fracturs showed a good clinical outcome in the majority of cases. Mandibular angle fracture is a common type of maxillofacial injury in our study population, with road traffic accidents being the most common cause. Early diagnosis and appropriate management of mandibular angle fractures can prevent long-term complications and improve patient outcomes.
Peripheral ossifying fibroma-Case report
Authors: Gangwar Shilpi , Kumari Priya , Chaudhary Umesh Chandra 
Published: April 2023

Peripheral ossifying fibroma is a reactive lesion arising from periodontal cells in response to local irritation with females in second decade of their life are more affected and with maxillary anterior region predilection. Clinical appearance with erythmatous or pink in colour with large lesions are generally smooth. Lesion usually not exceed 1.5 cm. Underlying bone sometimes shows loacalized bone erosion. Treatment usually involves exicision of the lesion with histopathological examination. Chances of recurrence after complete removal is higher. 19 year old female patient came with complain of swelling of gingiva at 43 44 region with clinical examination reveal 1cm × 1cm lesion with pink in colour and smooth surface and radiographic examination showing localized bone loss. After complete phase 1 therapy, exision of the lesion was performed and excised lesion was tranferd in 10% formalin for histopathological examination immediately. Hyperplastic stratified parakeratinized epithelium with connective tissue stroma havind osteocytes and osteoblasts and cementum like material lead to diagnosis of Peripheral Ossifying Fibroma(POF). POF is a third most common gingival reactive lesion. Histopathological and clinical examination require to confirms the diagnosis.
ПОДГОТОВКА ПОПУТНО НЕФТЯНОГО ГАЗА С ВЫСОКИМ СОДЕРЖАНИЕМ СЕРОВОДОРОДА НА ПРИМЕРЕ МЕСТОРОЖДЕНИЯ Х
Authors: Девлешова Наталья Алексеевна , Воропаев Александр Александрович 
Published: April 2023

Ссылка для цитирования: Девлешова Н.А., Воропаев А.А. Подготовка попутно нефтяного газа с высоким содержанием сероводорода на примере месторождения Х // Известия Томского политехнического университета. Инжиниринг георесурсов. – 2023. – Т. 334. – № 4. – С.221-230.
Актуальность. Флюиды месторождений на территории Российской Федерации обладают высоким содержанием серосодержащих соединений, в частности сероводорода. Ввиду такой особенности многие газо- и нефтедобывающие компании теряют выручку с продажи подобного углеводородного сырья. Содержание сероводорода во флюиде на месторождении Х выше 5 масс. %. На данный момент попутный нефтяной газ поставляется на газоперерабатывающем заводе по стоимости 2400 р. за 1000 м3, вследствие чего экономическая эффективность рассматриваемого проекта падает. Для решения данной проблемы предложено строительство блока подготовки попутного нефтяного газа до требований системы стандартизации ОАО «Газпром» (СТО Газпром) «Газ горючий, природный, поставляемый и транспортируемый по магистральным газопроводам» (089-2010) в рамках реинжиниринга объекта подготовки нефти и газа, что позволит сбывать попутный нефтяной газ по цене 4500 р. за 1000 м3. Цель: сформировать концепцию повышения рентабельности проекта в рамках реинжиниринга с помощью предложенного решения очистки попутного нефтяного газа от сероводорода и получения серы из кислого газа. Методы: поиск и анализ достоинств и недостатков технологий очистки газа, моделирование выбранной технологии в ПО «Hysis» для определенной производительности и получение материального баланса для проектирования установки. Результаты. Процесс подготовки газа предусматривает сепарацию, блок абсорбционной очистки попутного нефтяного газа от сероводорода и диоксида углерода аминами, блок адсорбционной осушки газа по извлечению меркаптанов и осушке цеолитами NaX (13X) и блок извлечения элементарной серы. Выводы. В ходе моделирования получена схема аминной очистки газа с параметрами материального баланса, согласующимися с требованиями системы стандартизации ОАО «Газпром» (СТО Газпром) «Газ горючий, природный, поставляемый и транспортируемый по магистральным газопроводам» (089-2010). Вследствие чего полученный газ рекомендуется подавать в единую систему газоснабжения. Кислые газы утилизируются при помощи смоделированной установки Клауза.
РЕСУРСОСБЕРЕГАЮЩАЯ ТЕХНОЛОГИЯ УТИЛИЗАЦИИ ПОРОДНЫХ ОТВАЛОВ ГОРНОДОБЫВАЮЩИХ ПРОИЗВОДСТВ
Authors: Козырь Дмитрий Александрович , Шаповалов Валерий Васильевич 
Published: April 2023

Ссылка для цитирования: Шаповалов В.В., Козырь Д.А. Ресурсосберегающая технология утилизации породных отвалов горнодобывающих производств// Известия Томского политехнического университета. Инжиниринг георесурсов. – 2023. – Т. 334. – № 4. – С.175-184.
Актуальность исследования. Мировой спрос на уголь в 2022 г. достиг исторического максимума 2013 г. и составил 8 млрд т. Увеличение спроса на уголь привело к интенсификации его добычи и, соответственно, к увеличению количества техногенных отходов – породных отвалов. Породные отвалы опасны для окружающей среды, однако их химический состав позволяет рассматривать породные отвалы как техногенные месторождения. Цель: разработка ресурсосберегающей технологии утилизации породных отвалов горнодобывающей промышленности с получением глинозема и других полезных компонентов. Объект: породные отвалы угольных шахт. Методы: экспериментальные исследования влияния режима спекания шихты аргиллит–сода‒мел на степень извлечения глинозема из аргиллита и на качество спека: определение массовой доли оксида алюминия титриметрическим методом; определение количества диоксида углерода в образцах волюмометрическим методом; определение потери влаги и продуктов реакций при прокаливании гравиметрическим методом. Результаты. Проведен анализ содержания полезных компонентов в породных отвалах Донбасса, а также существующих технологий извлечения глинозема из техногенных месторождений с низким содержанием алюминия. Техногенные отходы могут быть значительной сырьевой базой производства на многие годы. Кроме получения востребованной продукции, переработка техногенных отходов позволит повысить уровень экологической безопасности горнопромышленных агломераций. Рассмотрена технология утилизации породных отвалов с применением метода спекания шихты порода–сода–мел. В ходе экспериментальных исследований было установлено, что метод спекания с добавлением соды, несмотря на относительно небольшой процент извлечения глинозема (75,2 %), позволяет значительно снизить температуру спекания шихты (до 850 °С) и повысить энергоэффективность метода.