bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of ChatGPT in Dentistry: Multi-specialty and multi-centric study
Authors: Sybil Deborah , Shrivastava Priyanshu , Rai Arpita , Injety Ranjit , Singh Sanjay , Jain Ashish , Mahuli Amit , Parushetti Anita , Sharma Anka , Sivakumar Arvind , Narang Bindiya , Sultan Farheen , Shah Gaurav , Sridha Gokul , Augustine Jeyaseelan , Ranjan Madhu , Singh Neelam , Mehta Nishant , Sultan Nishat , Batra Panchali , Singh Sangita , Goel Sapna , Roy Sayani , Sachdeva Shabina , Tapashetti Sharmila , Mahuli Simpy , Kannan Sridhar , Verma Sugandha , . Tushar , Yadav Vijay , Gupta Vivek 
Published: September 2023

Abstract
Background: Artificial Intelligence (AI) powered tools have transformed the field of healthcare. A recently launched large language model, ChatGPT has gained significant traction due to its communicative interface and relevance of the responses generated. This tool could be utilized in dentistry for dental education, and possibly as a clinical decision support system. Hence, it is imperative to evaluate the accuracy of the model in relation to the responses generated for dental-related queries.

Methods: This multi-centric study involved 27 subject experts from nine dental specialties of various institutions and 2 heads of institutions. A total of 243 questions were formulated and the answers generated by ChatGPT (version: 3.5) were rated in terms of accuracy (6-point Likert), completeness (4-point Likert), and relevance (5-point Likert).

Results: The mean accuracy of the ChatGPT-generated answers was 4.61 (SD 1.575), with a median of 5.33. For completeness, mean score was 2.01 (SD 0.793), and the median was 2.33. Regarding relevance, a mean of 3.13 (SD 1.590) and median of 3.67 were obtained. The highest ratings were observed for answers related to Oral Medicine and Radiology, as well as for open-ended questions, and questions labelled as easy in terms of difficulty.

Conclusion: The promising results observed in the study promote the application of ChatGPT for retrieving dental information. However, it is crucial to exercise caution and seek advice from a qualified healthcare for dental health-related queries. Further large-scale testing of the model is necessary before incorporating it into dental clinical practice.
Assessing Emerging and Priority Micropollutants in Sewage Sludge: Environmental Insights and Analytical Approaches
Authors: Rede Diana , Teixeira Ivan , Delerue-Matos Cristina , Fernandes Virginia Cruz 
Published: September 2023

Abstract
This study presents a thorough evaluation of emerging and priority micropollutants in sewage sludge (SS), through the lens of environmental insights, by developing and implementing an integrated analytical approach. A quick, easy, cheap, effective, rugged and safe (QuEChERS) extraction method, coupled with gas chromatography and liquid chromatography, was optimized for the determination of 42 organic compounds. These include organophosphorus pesticides, organochlorine pesticides, pyrethroid pesticides, organophosphate ester flame retardants, polybrominated diphenyl ethers, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons. The optimization of the dispersive-solid phase for clean-up, combined with the optimization of chromatographic parameters, ensured improved sensitivity. Method validation included assessments for recovery, reproducibility, limit of detection (LOD), and limit of quantification (LOQ) assessments. Recoveries ranged from 59.5–117%, while LODs ranged from 0.00700 µg g− 1 to 0.271 µg g− 1. Application of the method to seven SS samples from Portuguese wastewater treatment plants revealed the presence of sixteen compounds, including persistent organic pollutants. Notably, the quantification of α-endosulfan, an organochlorine pesticide, was consistently observed in all samples, with concentrations ranging from 0.110 µg g− 1 to 0.571 µg g− 1. Furthermore, the study encompasses the analysis of agronomic parameters, as well as the mineral and metal content in SS samples. The study demonstrates that the levels of heavy metals comply with legal limits. By conducting a comprehensive investigation into the presence of micropollutants in SS, this study contributes to a deeper understanding of the environmental and sustainable implications associated with SS management.
Study protocol for a randomized, controlled, multicentre, pragmatic trial with Rehabkompassen® – A digital structured follow-up tool for facilitating patient-tailored rehabilitation in persons after stroke
Authors: Hu Xiaolei , Liv Per , Lundström Erik , Norström Fredrik , Lindahl Olof , Borg Kristian , Sunnerhagen Katharina S 
Published: September 2023

Abstract
Background
Stroke is a leading cause of disability among adults worldwide. A timely structured follow-up tool to identify patients’ rehabilitation needs and develop patient-tailored rehabilitation regimens to decrease disability is largely lacking in current stroke care. The overall purposes of this study are to evaluate the effectiveness of a novel digital follow-up tool, Rehabkompassen®, among persons discharged from acute care settings after stroke.
Methods
This multicentre, parallel, open-label, two-arm pragmatic randomized controlled trial with an allocation ratio of 1:1 will be conducted in Sweden. A total of 1106 adult stroke patients will have follow-up visits in usual care settings at 3 and 12 months after stroke onset. At the 3-month follow-up, participants will have a usual outpatient visit without (control group, n = 553) or with (intervention group, n = 553) the Rehabkompassen® tool. All participants will receive the intervention at the 12-month follow-up visit. Feedback from the end-users (patient and health care practitioners) will be collected after the visits. The primary outcomes will be the patients’ independence and social participation at the 12-month visits. Secondary outcomes will include end-users’ satisfaction, barriers and facilitators for adopting the instrument, other stroke impacts, health-related quality of life, and the cost-effectiveness of the instrument, calculated by incremental cost per quality-adjusted life year (QALY).
Discussion
The outcomes of this trial will inform clinical practice and health care policy on the role of the Rehabkompassen® digital follow-up tool in the postacute continuum of care after stroke.
Trial registration
ClinicalTrials.gov Identifier: NCT04915027, Registered on 4 June 2021.
Combined surgery and radiotherapy for synchronous multiple primary lung cancers: a clinical retrospective study
Authors: Kawagishi Sachi , Kanzaki Ryu , Watari Hirokazu , Omura Akiisa , Tanaka Ryo , Maniwa Tomohiro , Tanaka Kazunori , Ikawa Toshiki , Kanayama Naoyuki , Morimoto Masahiro , Konishi Koji , Okami Jiro 
Published: September 2023

Abstract

Background
The recommended treatment strategy for early-stage synchronous multiple primary lung cancers (sMPLC) involves multiple resections of all lesions, if possible. However, some patients with sMPLC cannot tolerate multiple surgeries due to comorbidities or deterioration in lung functions. We aimed to analyze the outcomes of the combination of surgery and radiotherapy for sMPLC.
Methods
The clinical data of patients who underwent treatment with a combination of surgery and radiotherapy for sMPLC at a single center were collected, and the outcomes were analyzed.
Results
Among 3578 patients with non-small cell lung cancer who underwent surgical resection with curative intent, 332 had sMPLC. Of these, 20 received a combination of surgery and radiotherapy for each tumor. Sixteen patients were male, and four were female. The median patient age was 74 years (range: 60–84 years). The median follow-up period after pulmonary resection was 42 months (range: 7–184 months). The median tumor size was 18.5 mm (range, 10–55 mm) in the first cancer and 11.9 mm (range, 4–29 mm) in the second. Pulmonary resection was performed in the first cancer, with lobectomy for nine patients, and segmentectomy and wedge resection were performed for seven and four patients, respectively. Radiotherapy was administered in the second cancer. Stereotactic body radiation therapy, 3-dimensional conformal radiation therapy, and particle radiotherapy were performed in ten, eight, and two patients, respectively. Six patients died, while 14 patients were alive. Four patients died from lung cancer and two died from other diseases. The 3-year overall survival rate was 72.4%, and the 3-year progression-free survival rate was 69.6%. The 3-year local control rate for the second cancer was 95.0%.
Conclusions:
Treatment with a combination of surgery and radiotherapy is a viable option for sMPLC, when surgical resection cannot be performed for all lesions.
The effect of etomidate versus midazolam-sodium thiopental on attenuating the cardiovascular response to laryngoscopy and tracheal intubation.
Authors: Shetabi Hamidreza , farsani Darush moradi , Alafchian Zahra 
Published: September 2023

Abstract

Introduction: Laryngoscopy and tracheal intubation lead to an increase in the sympathetic reflex response, which is associated with an increase in heart rate and blood pressure. This response can be harmful in high-risk patients. The aim of this study is to investigate the effects of etomidate compared with midazolam and sodium thiopental in weakening the sympathetic response to laryngoscopy and tracheal intubation. Methods: This double-blind clinical study was conducted in 2020 at Al-Zahra Hospital in Isfahan on two groups of 39 candidates for elective surgery under general anesthesia. Anesthesia was induced by etomidate (E) 0.3 mg/kg in the first group and sodium thiopental 2.5 mg/kg and midazolam 0.075 mg/kg in the second group (TM), then the patient was intubated. Laryngoscopy findings and cardiovascular response were evaluated during the study and finally the data were analyzed using SPSS version 23. (IBM SPSS, Armonk, NY, USA). Results: There was no significant difference between the two groups in terms of age (P = 0.82), weight (P = 0.42), height (P = 0.201), body mass index (P = 0.78), gender (P = 0.65), American Society of Anesthesiologists (ASA) physical status (P = 0.36) and laryngoscopy view grading (P = 0.83). The average laryngoscopy time in E group was less than TM group (P = 0.019). In the TM group at 10 minutes after intubation, mean diastolic blood pressure (P = 0.029) and mean arterial blood pressure (P = 0.023) were significantly lower, but at other times there was no significant difference between the two groups (P > 0.05).There was no significant difference between the two groups in terms of adverse responses to laryngoscopy and intubation (P = 0.19). Conclusion: The results of this study showed that the cardiovascular response to laryngoscopy and tracheal intubation in both groups is similar and it seems that TM instead of E can be used as needed.
Myth or Fact: 3D-printed off-the-shelf prosthesis is superior to Titanium mesh cage in anterior cervical corpectomy and fusion
Authors: He Haoyu , Fan Lei , Lü Guohua , Li Xinyi , Li Yunchao , Zhang Ou , Chen Zejun , Yuan Hui , Wang Xiaoxiao , Pan Changyu , Kuang Lei 
Published: September 2023

Abstract
Objective To find out if 3DP OTS prosthesis is superior to TMC in ACCF when treating single-segment DCSM.
Methods DCSM patients underwent ACCF from January 2016 to January 2019 in a single center were included. Patients were divided into the 3DP group (28) and the TMC group (23). The hospital stays, operation time, intraoperative blood loss, and the cost of hospitalization were compared. The JOA scores and NDI were recorded pre-operatively, 1 day, 3, 6, 12, and 24 months post-operatively. Radiological data was measured to evaluate fusion, subsidence, and cervical lordosis. Patients were sent with SF-36 to assess their HRQoL.
Results The differences in operative time, intraoperative blood loss, and hospital stay were not statistically significant between groups (p>0.05). Postoperative dysphagia occurred in 2 cases in the 3DP group and 3 cases in the TMC group, which all relieved one week later. The difference in improvement of JOA and NDI between the two groups was not statistically significant (p>0.05). No hardware failure was found and bony fusion was achieved in all cases except one in the 3DP group. The difference in CL, FSA, MVH, and subsidence rates between groups at each follow-up time point was not statistically significant and the results of the SF-36 were similar (p>0.05). The total cost was higher in the 3DP group with its higher graft cost (p<0.05).
Conclusion In treating single-segment DCSM with ACCF, both 3DP OTS prosthesis and TMC achieved satisfactory outcomes. However, the more costly 3DP OTS prosthesis was not able to reduce subsidence as it claimed.
Association and interaction analysis of NLRP3 gene polymorphisms with hypertension risk: A case-control study in China
Authors: Xia Wanning , Qi Mingming , Liu Yupeng , Mi Jing , Song Jian , Wu Xuesen 
Published: September 2023

Abstract

Background
As an important mechanism for regulating inflammatory reactions, the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is considered the central pathogenic link of cardiovascular diseases. This study aimed to analyze the association and interaction between the rs10754558 polymorphism of NLRP3 and the risk of hypertension among Chinese adults.
Methods
All the participants who came from a community in Bengbu, China were investigated by being interviewed with a questionnaire. Overall, 354 paired case-control participants were analyzed. Genomic DNA was extracted from 5ml venous blood using the Tiangen DNA extraction kit. The rs10754558 polymorphism of the NLRP3 gene was genotyped by TaqMan allelic discrimination real-time PCR.The association between the rs10754558 polymorphism and hypertension risk was investigated by a logistic regression analysis. Furthermore, an additive interaction analysis was conducted using related indicators, including the relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (SI).
Results
Participants carrying the GG genotype were more likely to develop hypertension than participants carrying the CC genotype (adjusted odds ratio [OR]: 2.16, 95% confidence interval [CI]: 1.33–3.52). G allele carriers were 1.21 times more likely to have hypertension than non-G allele carriers. A significant additive interaction between the NLRP3 polymorphism and obesity status concerning the risk of hypertension was observed, as estimated by all indicators: RERI (1.12, 95% CI: 0.70–1.5), AP (0.34, 95% CI: 0.14–0.53), and SI (1.92, 95% CI: 1.03–3.59). The values of RERI (1.74, 95% CI: 0.37–3.11), AP (0.46, 95% CI: 0.21–0.70), and SI (2.62, 95% CI: 1.18–5.83) showed that a significant interaction between the rs10754558 polymorphism and a family history of hypertension.
Conclusions
Our results indicated that the NLRP3 rs10754558 polymorphism was significantly associated with the risk of hypertension among Chinese adults. Furthermore, there was a significant additive interaction between NLRP3 polymorphisms and obesity status concerning the risk of hypertension.
Community-based actions in consulates: a new paradigm for opportunities for systematic integration in Chagas disease detection
Authors: Prat Jordi Gómez i , Gregori Maria Serrano , Guiu Isabel Claveria , Choque Estefa , Flores-Chavez Maria Delmans , Molina Israel , Zarzuela Francesc , Sulleiro Elena , Dehousse Aurore , Albajar-Vinas Pedro , Ouaarab Hakima 
Published: September 2023

Abstract
Research has shown that multidimensional approaches to Chagas disease (CD), integrating its biomedical and psycho-socio-cultural components, are successful in enhancing early access to diagnosis, treatment and sustainable follow-up. For the first time, a consulate was selected for a community-based CD detection campaign. Two different strategies were designed and implemented between 2021 and 2022 at the Consulate General of Bolivia and a reference health facility in Barcelona. Strategy 1 consisted in CD awareness-raising activities before referring those interested to the reference facility for infectious disease screening. Strategy 2 offered additional in-situ CD screening. Most of the 307 participants were Bolivian women resident in Barcelona. In strategy 1, 73 people (35.8% of those who were offered the test) were screened and 19.2% of them were diagnosed with CD. Additionally, 53,4% completed their vaccination schedules and 28.8% were treated for other parasitic infections (strongyloidiasis, giardiasis, eosinophilia, syphilis). In strategy 2, 103 people were screened in-situ (100% of those who were offered the test) and 13.5% received a CD diagnosis. 21,4% completed their vaccination schedule at the reference health facility and 2,9% were referred for iron deficiency anemia, strongyloidiasis or chronic hepatitis C. The location of the screening, together with the presence of community-based participants, fueled trust and increased CD understanding. Each of the strategies assessed had different benefits. Opportunities for systematic integration based on community action in the official workplace of representatives of their own country may enhance early access to diagnosis, care and disease prevention.
Anticancer Medicinal Plants Used by Residents in the Elgon Sub-region, Eastern Uganda
Authors: Kudamba Ali , Kasolo Josephine N. , Bbosa Godfrey S. , Lugaajju Allan , Wabinga Henry , Niyonzima Nixon , Ocan Moses , Damani Ali M. , Kafeero Hussein M. , Walusansa Abdul , Ssenku Jamilu E. , Alemu Shaban O. , Lubowa Muhammad , Muwonge Haruna 
Published: September 2023

Abstract

Background: In Uganda, medicinal plants have been utilized to treat a variety of ailments, including cancer. The anticancer medicinal herbs employed in the Elgon sub-region, however, have only been the subject of a relatively small number of investigations. This study's major objective was to document the anticancer medicinal plants used to treat cancer in the Elgon sub-region of eastern Uganda, with a focus on prostate cancer.Methods:A semi-structured questionnaire that was administered by the researcher, interview guides, and guided field trips were used to collect ethnobotanical data. A number of quantitative indices were assessed, including informant consensus factor (ICF), fidelity level (FL), and preference ranking. A descriptive statistical analysis and graphs were produced using SPSS version 21.0 and GraphPad Prism version 8.125 respectively. The narratives were then interpreted using major theories and hypotheses in ethnobotany.Results:A total of 50 plant species from 36 families were documented and herbal knowledge was mainly acquired through inheritance. Most of the plant species revealed in this study belonged to the Fabaceae and Asteraceae families.Hydnora abyssinica A. Br. was mostly recommended by herbalists for prostate, cervical, and breast malignancies.Tylosema fassoglensiswas the most favored in regard to its ability to treat all known cancers in the area. The majority were collected from forest reserves (63%); herbal therapies were made from herbs (45%); and were primarily decocted (43%) from leaves (40%).Conclusions:The first 10 most often used plants all had FLI (71), ICF (0.8), and PV (60), values that were quite high, indicating that they are believed to be the most effective in treating the known cancers in this area. Therefore, further study is required to determine the phytochemistry, toxicity, and efficacy of these plants in order to develop a newer anticancer drug.
Clinical and epidemiological characteristics of human metapneumovirus infections in Central China post COVID-19 pandemic: a retrospective analysis
Authors: Ji Wangquan , Chen Yu , Han Shujie , Dai Bowen , Li Kang , Li Shuang , Li Zijie , Chen Shouhang , Zhang Yaodong , Zhang Xiaolong , Wang Qingmei , Zheng Jiaying , Wang Chenyu , Liang Qiujing , Han Shujuan , Zhang Ruyu , Wang Fang , Jin Yuefei , Li Xiaolong 
Published: September 2023

Abstract
Purpose
We aim to describe the clinical and epidemiological characteristics of human metapneumovirus (HMPV) infections after COVID-19 pandemic.
Methods
This retrospective single-center study included participants with laboratory confirmed HMPV infection who were admitted to Henan Children's Hospital from April 29 to June 5, 2023. Demographic data, clinical records, and laboratory indicators were analyzed. Stratified analysis was performed based on the duration from illness onset to hospitalization.
Results
From April 29 to June 5, 2023, 96 pediatric patients (33.5 months, interquartile range (IQR) 12 ~ 48 months), were identified to be infected with HMPV. The majority (87.5%) of infected children were no more than 5 years and the distribution of age among severe and mild groups was significantly different. Most patients had fever (81.3%) or cough (92.7%) and more patients in the severe group had wheezing (56% vs 21.1%). 43 patients were infected by one other viruses and coinfection with EBV (15.6%) or HRV type A (12.5%) was the most common. The rate of HRSV coinfection was significantly higher in the severe group (20% vs 1.4%). Bacterial coinfection was detected among 74 patients, including Hin in 50 children (52.1%), SNP in 40 children (41.7%). There was greater evidence of multiple-organ damage in severe patients, since severe patients presented with much more abnormal levels of laboratory indicators. Lower concentration of IL-12p70, decline of lymphocytes percentage, and elevated percentage of B lymphocyte in severe patients exhibited a statistical significance. Additionally, most of the indicators changed significantly after 4 ~ 5 days of onset.
Conclusions
Our data systemically presented the clinical and epidemiological features of pediatric patients with HMPV infection, which might be instructive to policy development for the prevention and control of HMPV infection and might provide important clues for HMPV research after the COVID-19 pandemic.
Antibiotic prophylaxis with piperacillin–tazobactam reduces organ/space surgical site infection after pancreaticoduodenectomy: A retrospective and propensity score-matched analysis
Authors: Yang Yifei , Sheng Jianjie , Cai Zhenghua , Zhu Linxi , Lu Chenglin , Mao Liang , Qiu Yu-dong , Fu Xu 
Published: September 2023

Abstract
Background
The occurrence of surgical site infection (SSI) after pancreaticoduodenectomy (PD) is still relatively high. The aim of this retrospective study is to evaluate the efficacy of piperacillin-tazobactam as perioperative prophylactic antibiotic on organ/space SSI for patients underwent PD.
Methods
407 consecutive patients who underwent PD between January 2018 and December 2022 were enrolled and analyzed retrospectively. The univariate and multivariate analysis were used to identify independent risk factors of organ/space SSI. Postoperative complications were compared between the two groups according to the use of prophylactic antibiotics by a ratio of 1:1 propensity score-matched (PSM) analysis.
Results
Based on perioperative prophylactic antibiotic use, all 407 patients were divided into the ceftriaxone group (n = 192, 47.2%) and piperacillin–tazobactam group (n = 215, 52.8%). The rate of organ/space SSI was 31.2% with the choice of perioperative antibiotics (OR = 2.837, 95%CI = 1.802–4.465, P < 0.01) as one of independent risk factors. After PSM, there were similar baseline characteristics among the groups. Meanwhile, the piperacillin–tazobactam group had a significant lower rate of organ/space SSI (P < 0.05) compared to the ceftriaxone group both before and after PSM.
Conclusions
The adoption of piperacillin–tazobactam as perioperative prophylaxis for patients underwent PD reduced organ/space SSI significantly.