bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional Book and Print Trades
Authors: Stenner Rachel 
Published: September 2023

Abstract
This chapter narrates the development of the regional book and print trades in England in the early modern period. It has a particular focus on newspaper publishing. The chapter first argues that ‘regional’ is a preferable term to ‘provincial’ when discussing the trades outside London. The chapter then surveys the existing scholarship and outlines the institutional and legislative factors governing the trades. Finally, the chapter presents three short case studies of particular locations: Oxford, York, and Newcastle. For each case study, the chapter traces the unique historical factors influencing that location’s development as a centre for book and print production.
Printing and the Universities
Authors: Peacey Jason 
Published: September 2023

Abstract
This essay traces continuity and change—as well as both visionary thinking and pragmatic experimentation—in relation to the development of learned printing in Oxford and Cambridge. In tracing the ambitions and the challenges that were involved in bringing English printing up to European standards, it explores evidence of the financial, logistical, and administrative dimensions of the print industry, as well as the status and skills of university printers over successive generations. It also situates university printing within the wider context of the English book trade, in terms of both government regulation and fraught relations with the Stationers’ Company. Ultimately, it uses rich surviving documentation regarding the mechanics of printing in order to show how both institutions navigated political constraints and legal controversies, and how, amid considerable wrangling, progress was slowly made towards a situation in which it was possible to produce scholarly editions of remarkably high quality.
The Early Modern Book as Metaphor
Authors: Dolven Jeff 
Published: September 2023

Abstract
No object, save the human body itself, is as generous with figurative possibility as a book. Its metaphorical affordances in the sixteenth and seventeenth centuries begin with the durable features of the codex’s physiology, pages, binding, spine, but equally exploit the changing technologies of printing and the circumstances of the marketplace. This essay canvasses a range of persons and things that were said to be books: bodies, memories, worlds, prophecies, food, drink, commodities, buildings, friends, children. The principal protagonists are Edmund Spenser (a book fantasist: the books in his book are unlike his own book) and Ben Jonson (a book realist: he writes about books like his own). Across these diverse materials the story is told of a historical shift from authorial identification with the capacity of style, to identification with the achievement of a book.
Printing and Book History
Authors: Franklin Alexandra , Lawrence Richard 
Published: September 2023

Abstract
Practical experience of printing is one tool for teaching the early modern book. Haptic learning opens insights into the book as a material object. The aim of such teaching has been to make tangible the dynamics of the creative process and to recapture the point of view of the mostly anonymous craftspeople whose skills and labour contributed to the finished book. The practical exercise of a craft within an academic field of study also prompts us to consider the aesthetic qualities of books not as critics but from the perspective of the makers. This chapter recommends basic materials and equipment as well as exercises to illustrate key points in teaching about the early modern book. It also provides a background to, and a very short history of, practical printing as part of bibliographical and book-historical teaching.
Smooth Elongation of Pavement Cells Induced by RIC1 Overexpression Leads to Marginal Protrusions of the Cotyledon in Arabidopsis thaliana
Authors: Kikukawa Kotomi , Takigawa-Imamura Hisako , Soga Kouichi , Kotake Toshihisa , Higaki Takumi 
Published: September 2023

Abstract
The interdigitated pavement cell shape is suggested to be mechanically rational at both the cellular and tissue levels, but the biological significance of the cell shape is not fully understood. In this study, we explored the potential importance of the jigsaw puzzle-like cell shape for cotyledon morphogenesis in Arabidopsis. We used a transgenic line overexpressing a Rho-like GTPase-interacting protein, ROP-INTERACTIVE CRIB MOTIF-CONTAINING PROTEIN 1 (RIC1), which causes simple elongation of pavement cells. Computer-assisted microscopic analyses, including virtual reality observation, revealed that RIC1 overexpression resulted in abnormal cotyledon shapes with marginal protrusions, suggesting that the abnormal organ shape might be explained by changes in the pavement cell shape. Microscopic, biochemical and mechanical observations indicated that the pavement cell deformation might be due to reduction in the cell wall cellulose content with alteration of cortical microtubule organization. To examine our hypothesis that simple elongation of pavement cells leads to an abnormal shape with marginal protrusion of the cotyledon, we developed a mathematical model that examines the impact of planar cell growth geometry on the morphogenesis of the organ that is an assemblage of the cells. Computer simulations supported experimental observations that elongated pavement cells resulted in an irregular cotyledon shape, suggesting that marginal protrusions were due to local growth variation possibly caused by stochastic bias in the direction of cell elongation cannot be explained only by polarity-based cell elongation, but that an organ-level regulatory mechanism is required.
The Brexit Vote, Productivity Growth, and Macroeconomic Adjustments in the U.K.
Authors: Broadbent Ben , Di Pace Federico , Drechsel Thomas , Harrison Richard , Tenreyro Silvana 
Published: September 2023

Abstract
The U.K. economy experienced significant macroeconomic adjustments following the 2016 referendum on its withdrawal from the European Union. To understand these adjustments, this paper presents empirical facts using novel U.K. macroeconomic data and estimates a small open economy model with tradable and non-tradable sectors. We demonstrate that the referendum outcome can be interpreted as news about a future decline in productivity growth in the tradable sector. An immediate fall in the relative price of non-tradable goods induces a temporary “sweet spot” for tradable producers. Economic activity in the tradable sector expands in the short run, while the non-tradable sector contracts. Aggregate output, consumption, and investment growth decelerate.
Electron paramagnetic resonance dose measurements in teeth of tissue donors to the United States Transuranium and Uranium Registries
Authors: Romanyukha A , Tolmachev S Y 
Published: September 2023

Abstract
The United States Transuranium and Uranium Registries (USTUR) is a research program that studies actinide biokinetics in occupationally exposed individuals with known intakes of these elements. Electron paramagnetic resonance (EPR) in tooth enamel was applied to reconstruct external doses of nine USTUR registrants. Only in two cases there is a reasonable agreement between the EPR-measured dose and the worksite external dose record. For two registrants, high EPR doses can be explained by possible cancer radiotherapy. For the remaining five cases, EPR doses significantly exceed official occupational doses with no plausible explanation for the observed discrepancy. More EPR dose measurements need to be done to explain this anomaly.
Radiation exposure determination in a secure, cloud-based online environment
Authors: Shirley Ben C , Mucaki Eliseos J , Knoll Joan H M , Rogan Peter K 
Published: September 2023

Abstract
Rapid sample processing and interpretation of estimated exposures will be critical for triaging exposed individuals after a major radiation incident. The dicentric chromosome (DC) assay assesses absorbed radiation using metaphase cells from blood. The Automated Dicentric Chromosome Identifier and Dose Estimator System (ADCI) identifies DCs and determines radiation doses. This study aimed to broaden accessibility and speed of this system, while protecting data and software integrity. ADCI Online is a secure web-streaming platform accessible worldwide from local servers. Cloud-based systems containing data and software are separated until they are linked for radiation exposure estimation. Dose estimates are identical to ADCI on dedicated computer hardware. Image processing and selection, calibration curve generation, and dose estimation of 9 test samples completed in &lt; 2 days. ADCI Online has the capacity to alleviate analytic bottlenecks in intermediate-to-large radiation incidents. Multiple cloned software instances configured on different cloud environments accelerated dose estimation to within clinically relevant time frames.
Improvement of neutron sensitivity for lithium formate EPR dosemeters: a Monte Carlo analysis
Authors: D’Oca Maria Cristina , Collura Giorgio , Gagliardo Cesare , Bartolotta Antonio , Romeo Mattia , d’Errico Francesco , Marrale Maurizio 
Published: September 2023

Abstract
This work presents the computational analysis of the sensitivity improvements that could be achieved in lithium formate monohydrate (LFM) electron paramagnetic resonance (EPR) dosemeters exposed to neutron beams. Monte Carlo (MC) simulations were performed on LFM pellets exposed to neutron beams with different energy spectra at various depths inside a water phantom. Various computations were carried out by considering different enrichments of 6Li inside the LFM matrix as well as addition of different amounts of gadolinium oxide inside the pellet blend. The energy released per unit mass was calculated with the aim of predicting the increase in dose achievable by the addition of sensitizers inside the pellets. As expected, a larger amount of 6Li induces an increase of energy released because of the charged secondary particles (i.e. 3H ions and α-particles) produced after neutron capture. For small depths in water phantom and low-energy neutron spectra the dose increase due to 6Li enrichment is high (more than three orders of magnitude with respect to the case of with 7Li). In case of epithermal neutron beams the energy released in 6Li-enriched LFM compound is smaller but larger than in the case of fast neutron beams. On the other hand, the computational analysis evidenced that gadolinium is less effective than 6Li in improving neutron sensitivity of the LFM pellets. Discussion based on the features of MC transport code is provided. This result suggests that 6Li enrichment of LFM dosemeters would be more effective for neutron sensitivity improvement and these EPR dosemeters could be tested for dosimetric applications in Neutron Capture Therapy.
Investigation of the provenance of Okinose sand using ESR signals of quartz in granite and granodiorite around Osaka Bay
Authors: Kobayashi Ryo , Kojima Hibiki , Tani Atsushi 
Published: September 2023

Abstract
A submarine dune on the seabed in the Okinose area of Osaka Bay, Japan, was found to be composed mainly of coarse quartz sand. To investigate the provenance of this sand, quartz extracted from granite and granodiorite sources near Osaka Bay was measured by electron spin resonance; E1′, Ti-Li and Al centres were detected in all samples. Although the heat-treated E1′ centre was found not to be useful for the present provenance study, the ratio of the signal intensities of the Ti-Li centre to the Al centre classified the potential sources into two groups, based on their likelihood. The results indicated that granite and granodiorite from Awaji Island as well as Rokko granite could be the source of the Okinose sand.
The implementation of artificial intelligence to the low-cost metaphase finder
Authors: Furukawa Akira 
Published: September 2023

Abstract
Biological dosimetry is used to estimate one’s dose by biological phenomena. The most popular and ‘gold standard’ phenomenon is the appearance of dicentric chromosomes in metaphases. The metaphase finder is a tool for biological dosimetry that finds metaphase cells on glass slides. It consists of an automated microscope, auto-focus system, X-Y stage, camera and computer. It does the image analysis of the microscopic images of the glass slides and displays the positions of metaphase cells. In this paper, the author reported that the prototype of AI-implemented metaphase finder was combined with the microscope system by file sharing and image transfer program, and that the metaphase finder system’s accuracy was compared with previous non-AI system, using the same samples.
Estimation of external dose for wild Japanese macaques captured in Fukushima prefecture: decomposition of electron spin resonance spectrum
Authors: Mitsuyasu Yusuke , Oka Toshitaka , Takahashi Atsushi , Kino Yasushi , Okutsu Kenichi , Sekine Tsutomu , Yamashita Takuma , Shimizu Yoshinaka , Chiba Mirei , Suzuki Toshihiko , Osaka Ken , Sasaki Keiichi , Suzuki Masatoshi , Fukumoto Manabu , Shinoda Hisashi 
Published: September 2023

AbstractThe signal intensities of CO2− radicals in teeth can be utilised as an individual indicator of the cumulative external dose for animals. To accurately determine the external dose, it is desirable to analyse the CO2− radical intensity and improve its detection limit. We recently reported a dose–response in the range of 0–200 mGy and estimated the absorbed dose for seven wild Japanese macaques captured in/around the related areas to the Fukushima Daiichi Nuclear Power Plant accident. Herein, for further improvement of this method, we examined the electron spin resonance spectra of the teeth of these seven and an additional four macaques captured in Fukushima by applying two spectrum-decomposition algorithms.
Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p/CCL20
Authors: Li Yuejin , Li Rougang , Li Yu , Li Guosan , Zhao Yiman , Mou Houyu , Chen Yi , Xiao Le , Gong Kunmei 
Published: September 2023

Abstract:
Damage to the abdominal aortic wall and the local inflammatory response are key factors resulting in abdominal aortic aneurysm (AAA) formation. During this process, macrophage polarization plays a key role. However, in AAA, the regulatory mechanism of macrophages is still unclear, and further research is needed. In this study, we found that the transcription factor TCF3 was expressed at low levels in AAA. We overexpressed TCF3 and found that TCF3 could inhibit MMP and inflammatory factor expression and promote M2 macrophage polarization, thereby inhibiting the progression of AAA. Knocking down TCF3 could promote M1 polarization and MMP and inflammatory factor expression. In addition, we found that TCF3 increased miR-143-5p expression through transcriptional activation of miR-143-5p, which further inhibited expression of the downstream chemokine CCL20 and promoted M2 macrophage polarization. Our research indicates that TCF3-mediated macrophage polarization plays a key regulatory role in AAA, complementing the role and mechanism of macrophages in the occurrence and development of AAA and providing a scientific basis for AAA treatment.
Anaplastic Large Cell Lymphoma With Intraocular or Ocular Adnexal Involvement: A Case Report and Systematic Review
Authors: Rafizadeh Seyed Mohsen , Ghahvehchian Hossein , Rajabi Mohammad Taher , Heidari Mostafa , Rahmanikhah Elaham 
Published: September 2023

Purpose:
To review the existing literature on patients with anaplastic large cell lymphoma (ALCL) affecting the globe and/or ocular adnexa, and to present a report documenting the clinical course of a patient with ALCL that involved their globe and ocular adnexa.

Methods:
PubMed, Scopus, and Google scholar were systematically searched for all cases of ALCL involving intraocular or adnexal ocular structures from inception to May 2023. Moreover, a new reported case added to the cases found in searches.

Results:
The review identified 1680 studies, with 8 meeting inclusion criteria. A total of 9 patients were included with a mean age of 29.7 years (median: 30.0, range: 1.3–48). Primary ALCL was present in 5/9 (55.6%) patients. The most common ophthalmic manifestations included periorbital swelling (5/8), chemosis (5.8), and decreased vision (5/7). Misdiagnoses were initially made in 3 patients, and the lag time to correct diagnosis from 3 weeks to 3 months. CD30 expression was positive in all cases, and 6/9 patients were positive for anaplastic lymphoma kinase, resulting in 6/9 patients being diagnosed with anaplastic lymphoma kinase-positive ALCL. In terms of management modalities, chemotherapy was administered in 8/9 patients, while radiation therapy was utilized in 4/9 patients, and 2 underwent autologous stem cell transplantation. Five (55.6%) patients succumbed to ALCL while 4 (44.4%) were alive and disease-free at the last follow-up. The median times from the initial presentation of ALCL to death, ophthalmic presentation to death, and diagnosis to death were 4.12 months (range: 1.1–168.0), 2.62 months (range: 1.1–144), and 4.00 months (range: 0.10–168), respectively. The median follow-up duration was 21.0 months (range: 1.1–168.0).

Conclusions:
ALCL involving the globe and ocular adnexa is a rare and highly malignant tumor that can mimic benign clinical conditions. Early biopsy and aggressive treatment with chemotherapy regimens such as CHOP and radiation therapy may be useful.
Clinical outcomes of conversion surgery following immune checkpoint inhibitors and chemotherapy in stage IV gastric cancer
Authors: Liang Huayuan , Yan Xiao , Chen Xinhua , Li Zhiwei , Qiu Yaopeng , Li Fengping , Wang Minghao , Huang Zhicheng , Huang Kaihua , Xie Qing , Zhang Huimin , Li Guoxin , Liu Hao , Zhao Liying 
Published: September 2023

Background:
The clinical benefit of conversion surgery following immunochemotherapy in patients with stage IV gastric cancer (GC) remains uncertain. This study aims to clarify the clinical outcomes of conversion surgery for such patients.

Methods:
This retrospective cohort study enrolled consecutive patients with stage IV GC treated with a combination of immune checkpoint inhibitors (ICIs) and chemotherapy and/or anti-HER2 targeted therapy as first-line therapy. Cumulative survival curves were estimated using Kaplan-Meier method. Logistic regression and Cox regression analyses were conducted to identify factors associated with conversion surgery and survival, respectively.

Results:
Among the 136 patients included in the study. The disease control rate was 72.1% (98/136), with objective response rate in 58.8% (80/136) and complete response rate in 5.9% (8/136). Among 98 patients with disease control, 56 patients underwent palliative immunochemotherapy with median PFS and OS at 9.2 and 16.2 months, respectively; the remaining 42 patients underwent conversion surgery, yielding an unreached median PFS over a 19.0-month median follow-up, accompanied by one-year OS and PFS rates of 96.6% and 89.1%, respectively. The R0 resection rate reached 90.5% (38/42). 7 out of 42 patients achieved pathological complete response, of whom 3 patients demonstrated HER2 positivity. No serious complications leading to death were observed during the perioperative period. Multivariate analysis indicated that PD-L1 CPS ≥5 (odds ratio, 0.22; 95% CI, 0.08-0.57; P=0.002) favored successful conversion surgery, while signet ring cell carcinoma (hazard ratio, 6.29; 95% CI, 1.56–25.36; P=0.010) was the poor prognostic factor associated with survival in patients who underwent conversion surgery.

Conclusions:
Conversion surgery holds the potential for significant survival benefits in stage IV GC patients who have achieved a favorable clinical response to immunochemotherapy. Individuals with signet ring cell carcinoma may experience increased post-conversion surgery recurrence.
Long-term outcomes of microsurgery and stereotactic radiosurgery as the first-line treatment for arteriovenous malformations: A propensity score-matched analysis using nationwide multicenter prospective registry data
Authors: Han Heze , Gao Dezhi , Ma Li , Li Ruinan , Li Zhipeng , Zhang Haibin , Yuan Kexin , Wang Ke , Zhang Yukun , Zhao Yang , Jin Weitao , Jin Hengwei , Meng Xiangyu , Yan Debin , Li Runting , Lin Fa , Hao Qiang , Wang Hao , Ye Xun , Kang Shuai , Pu Jun , Shi Zhiyong , Chao Xiaofeng , Lin Zhengfeng , Lu Junlin , Li Youxiang , Zhao Yuanli , Sun Shibin , Chen Yu , Chen Xiaolin , Wang Shuo ,   on behalf of Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China (MATCH)
Published: September 2023

Background:
This study aimed to compare the risk and benefit profile of microsurgery (MS) and stereotactic radiosurgery (SRS) as the first-line treatment for unruptured and ruptured arteriovenous malformations (AVMs).

Materials and Methods:
We included AVMs underwent MS or SRS as the first-line treatment from a nationwide prospective multicenter registry in *BLINDED*. We used propensity score-matched methods to balance baseline characteristics between MS and SRS groups. The primary outcomes were long-term hemorrhagic stroke or death, and the secondary outcomes were long-term obliteration and neurological outcomes. Subgroup analyses and sensitivity analyses with different study designs were performed to confirm the stability of our findings.

Results:
Of 4286 consecutive AVMs in the registry from 2011.08 to 2021.12, 1604 patients were eligible. After matching, 244 unruptured and 442 ruptured AVMs remained for the final analysis. The mean follow-up duration was 7.0 years in the unruptured group and 6.1 years in the ruptured group. In the comparison of primary outcomes, SRS was associated with a higher risk of hemorrhagic stroke or death both in the unruptured and ruptured AVMs (unruptured: hazard ratio [HR] 4.06, 95%confidence interval [CI] 1.15-14.41; ruptured: HR 4.19, 95%CI 1.58-11.15). In terms of the secondary outcomes, SRS was also observed to have a significant disadvantage in long-term obliteration (unruptured: odds ratio [OR] 0.01, 95%CI 0.00-0.04; ruptured: OR 0.09, 95%CI 0.05-0.15). However, it should be noted that SRS may have advantages in preventing neurofunctional decline (unruptured: OR 0.56, 95%CI 0.27-1.14; ruptured: OR 0.41, 95%CI 0.23-0.76). Results of subgroup analyses and sensitivity analyses were consistent in trend but with slightly varied powers.

Conclusions:
This clinical practice-based real-world study comprehensively compared MS and SRS for AVMs with long-term outcomes. MS is more effective in preventing future hemorrhage or death and achieving obliteration, while the risk of neurofunctional decline should not be ignored.