bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on a Typical Casing Failure during Drilling of Cement Plugs in Ultradeep Wells
Authors: Ding Liangliang , Chen Wenkang , Han Chuanjun , Geng Hailong , Zhang Qiang 
Published: June 2023

Summary
Among the casing failures in 46 ultradeep wells in a particular block, 11 ultradeep wells had the same casing failure forms occur during the drilling of cement plugs. The casing failure forms are local bending deformation and local internal pressure damage, which eventually led to a local burst failure of the casing in the 11 typical ultradeep wells. Therefore, a casing strength checking model is established to investigate the primary reasons for the local burst failure of the casing and the local burst failure mechanism of the casing. A case study is performed on casing in typical ultradeep wells with force conditions to evaluate the safety state of the casing and make necessary recommendations to improve its safety. The obtained results indicate that an abnormally high dogleg (AHD), a decrease in the temperature at the bottom of the casing, and an annulus trap space are the characteristics of typical ultradeep wells, and the local burst failure of the casing is caused by the coupled superposition impact of a decrease in the annulus pressure buildup (APB), the casing temperature effect, and the magnification effect of the casing bending stress. The safety factor of the casing can be increased by changing the operation parameters and the material properties of the casing. To address the casing failure problems during the drilling of cement plugs in typical ultradeep wells, the protection and monitoring of the seal quality of the cement sheath should be improved to avoid expansion of the well diameter and formation of the annulus trap space. The casing strength and the injection temperature of the drilling fluid can be increased, and the drilling fluid displacement can be decreased.
Discovery of an OTUD3 inhibitor for the treatment of non-small cell lung cancer
Authors: Zhang Yonghui , Du Tongde , Liu Na , Wang Juan , Zhang Lingqiang , Li Chaonan , Zhang Xin , Wu Bo , Zhang Jinghao , Cui Chun-Ping , Li Hongchang , Jiang Wenli , Zhang Yubing , Zhang Yuting , Li Peiyu 
Published: June 2023

AbstractThe ubiquitin-proteasome system (UPS) controls protein turnover, and its dysfunction contributes to human diseases including cancer. Deubiquitinating enzymes (DUBs) remove ubiquitin from proteins to maintain their stability. Inhibition of DUBs could induce the degradation of selected oncoproteins and has therefore become a potential therapeutic strategy for cancer. The deubiquitylase OTUD3 was reported to promote lung tumorigenesis by stabilizing oncoprotein GRP78, implying that inhibition of OTUD3 may be a therapeutic strategy for lung cancer. Here, we report a small-molecule inhibitor of OTUD3 (named OTUDin3) by computer-aided virtual screening and biological experimental verification. OTUDin3 exhibited pronounced antiproliferative and proapoptotic effects by inhibiting deubiquitinating activity of OTUD3 in non-small-cell lung cancer (NSCLC) cell lines. Moreover, OTUDin3 efficaciously inhibited growth of lung cancer xenografts in mice. In summary, our results support OTUDin3 as a potent inhibitor of OTUD3, the inhibition of which may be a promising therapeutic strategy for NSCLC.
Comparison of 2-octyl Cyanoacrylate and N-octyl Cyanoacrylate Topical Skin Adhesives for Wound Closure after Ankle Fracture Surgery: A Prospective Randomized Trial
Authors: Park Young Hwan , Son Sei Wool , Han Sang Roc , Kim Hak Jun 
Published: June 2023

Abstract
To date, only a few clinical studies have investigated the differences between 2-octyl cyanoacrylate and n-octyl cyanoacrylate topical skin adhesives (TSAs). This study aimed to compare the outcomes of the two TSAs for wound closure after ankle fracture surgeries. Fifty-six patients were randomized to receive either a 2-octyl or n-octyl cyanoacrylate TSA. At 3 and 6 months after surgery, wound cosmetic outcomes were assessed using the Hollander wound evaluation scale (HWES), and patient satisfaction for wound cosmesis was assessed using the visual analog scale (VAS) and 5-item Likert scale. Functional outcomes at 6 months after surgery were assessed using the Olerud–Molander ankle score (OMAS). Fifty-five patients completed the study protocol. Within the follow-up period, no differences were found between the two groups in terms of HWES, VAS, 5-item Likert scale, and OMAS. 2-octyl cyanoacrylate TSA and n-octyl cyanoacrylate TSA were comparable options for wound closure after ankle fracture surgeries in terms of wound cosmesis, patient satisfaction, and functional outcome.
A 3-Layered Nonlinear Process Monitoring Strategy with a Novel Fault Diagnosis Approach
Authors: Mishra Bhagwan Kumar , Das Anupam 
Published: June 2023

Abstract
The article proposes the development of a layered process monitoring strategy based on Multi- Block Kernel Principal Component Analysis (MBKPCA). MBKPCA aids in the development of a distributed process monitoring strategy by taking into account the nonlinear relationships existing amongst the measured characteristics. A distributed process monitoring strategy stratifies the proposed process into a multi-layered structure comprising of blocks, sub-blocks etc. In this article an MBKPCA based monitoring strategy was devised for a Wire Rod Manufacturing Facility (WRMF) of an Integrated Steel Plant (ISP). The proposed monitoring strategy stratified the entire process into 3 layers, with the first layer comprising the manufacturing stages, the next layer comprising the sub-stages and the third layer comprising the characteristics to be monitored within the respective sub-stages. The detection of the fault was carried out with the aid of Kernel Principal Component Analysis (KPCA) score based Hotelling T2 chart. Fault detection was followed by Fault Diagnosis, for which new Fault Diagnostic Statistics were proposed which took into account the contribution of the main and the auxiliary characteristics. The study also proposed the concept of Cumulative Percent Contribution Ratio (CPCR) to limit the number of parameters (stages/sub-stages/characteristics) that needs to be retained in fault diagnosis.
Evaluation of graded recession of inferior oblique muscle for correction of different grades of V-pattern strabismus
Authors: sokeer Shaimaa H. , Ali Ahmed L. , Arafa El Sayed S. , Awara Amr M. , Shafik Heba M. 
Published: June 2023

Abstract
Background: V pattern identification is essential for a proper surgical management. Graded recession is a very logical approach to treat inferior oblique overaction (IOOA). The aim is to evaluate the efficacy of graded recession of inferior oblique muscle for correction of different grades of V pattern.
Methods:
Forty patients from 3 to 18 years old with V pattern strabismus and primary IOOA were evaluated by prism cover test to assess the grade of IOOA and amplitude of V-pattern. Graded recession of IO muscle depends on the amplitude of the V-pattern and degree of IOOA. Eight mm recession for amplitude 7.5° to 10° and mild IOOA (10° or +1) ,10 mm recession for amplitude 11°- 15° and moderate IOOA (11° -15 °or +2) and maximum recession for amplitude more than 15 °and marked IOOA (³ 15 ° or +3). Simultaneous correction of the horizontal deviation was performed. Follow up after I week,1 month ,3 month and 6-month.
Results:
The mean age of the study patients was 9 ± 4.261. Twenty patients (50%) had V-pattern esotropia, 12 (30%) exotropia, 4 (10%) orthotropic and four (10%) had Dissociated vertical deviation (DVD). Four cases 10% were of grade 1, 20 cases 50% grade 2 and 16 cases 40% were of grade 3. Of eighty eyes, 66 eyes 82.5% were fully corrected with no residual IOOA, and 14 eyes 17.5% were under corrected. V-pattern was corrected in 28 cases 70% and only 12cases 30% had residual V-pattern grade 1.
Conclusions:
Graded Recession of IO muscle is an effective technique for eliminating IOOA and can be graded according to the grade of IOOA, 8-mm recession for +1 overaction, 10-mm for +2 overaction, and 14-mm (maximum recession) for +3 overaction. The grade of IOOA correlates with the amplitude of V-pattern. The amount of recession correlates with preoperative IOOA and grade of V-pattern with frequent undercorrections obtained by the standard 8 mm recession. A +2 overaction merits a 10-mm recession of the inferior oblique. A +3 or +4 overaction merits a 14-mm maximal recession.
Clinical features and change in incidence of acute acquired comitant esotropia: a 15-year single-center study in South Korea
Authors: Kim Ju Mi , Shin Jeonghwa , Lee Young Ho , Lee Yeon-Hee 
Published: June 2023

Abstract
Background/Objectives: We investigated the clinical features and change in incidence of AACE in South Korea.Subjects/Methods: This study reviewed the medical records of new patients who visited the Strabismus and Pediatric Ophthalmology Clinic (clinic of YHL) from January 1, 2007, to December 31, 2021. Patients with AACE or intermittent exotropia (IXT) were eligible for inclusion in the study. Clinical features were retrieved, including age at onset, angle of deviation, refractive errors, neuroimaging findings, and treatment outcomes. For each year, the proportion of new AACE patients among all new patients who visited the clinic, and the ratio of new AACE patients to new intermittent exotropia (IXT) patients, were analyzed to estimate the incidence of AACE.Results Overall, 59 patients were included in the study. The mean age of the patients was 24.7 ± 9.3 years; the incidence of AACE was highest in teenagers and young adults. The proportion of new AACE among all new patients showed increasing trend and it was statistically significant. (Linear regression analysis, R2 = 0.778, p < 0.001). There was also a significantly increasing trend in the ratio of new AACE patients to new IXT patients (R2 = 0.803, p < 0.001).Conclusions A new type of AACE, distinct from the classic types, is increasingly common in South Korea; this increasing incidence also appears to be a global phenomenon. Large-scale investigations are needed to define the exact clinical features, incidence, and pathophysiology of this new type of AACE.
Geo-Environmental Factors and the Effectiveness of Mulberry Leaf Extract in Managing Malaria: A Study in Purulia District, West Bengal, India
Authors: Pradhan Sayantan , Hore Samrat , Roy Stabak , Manna Simi , Dam Paulami , Mondal Rittick , Ghati Amit , Biswas Trishanjan , Sharma Supriya , Singh Waikhom Somraj , Maji Suman Kumar , Roy Sankarsan , Basu Aparajita , Pandey Kailash C , Samanta Soumadri , Vashisht Kapil , Dolai Tuphan Kanti , Kundu Pratip Kumar , Mitra Saptarshi , Biswas Debasish , Shokriyan Masuma , Maity Amit Bikram , Mandal Amit Kumar , Ince Ikbal Agah 
Published: June 2023

Abstract
Malaria prevalence has become medically important as well as a socioeconomic impediment for the endemic regions, including Purulia, West Bengal. Geo-environmental variables, humidity, altitude, and land use patterns are responsible for malaria. For surveillance of the endemic nature of Purulia’s blocks, statistical and spatiotemporal factors analysis have been done here. Also, a novel approach for the Pf malaria treatment using methanolic leaf extract of Morus alba S1 has significantly reduced the parasite load. The EC50 value (1.852) of the methanolic extract of M. alba S1 with P. falciparum 3D7 strain is close to the EC50 value (0.998) of the standard drug chloroquine with the same chloroquine-sensitive strain. Further studies with an in-silico model have shown successful interaction between DHFR and the leaf extract. Both 1-octadecyne and oxirane interacted favourably, which was depicted through GC-MS analysis. The predicted binary logistic regression model will help the policy makers for epidemiological surveillance in malaria-prone areas worldwide when substantial climate variables create a circumstance favourable for malaria. From the in vitro and in silico studies, it can be concluded that the methanolic extract of M. alba S1 leaves is promising and may play an influential role in the Pf malaria treatment in the near future.
Association between stress hyperglycemia ratio and short-term mortality in patients with Craniocerebral diseases: A retrospective cohort study
Authors: Dong Yukang , Huang Rui , Zhang Longjiu , fu Jiangquan 
Published: June 2023

Abstract

Background the aim of the present study was to investigate the relationship between admission stress hyperglycemia ratio (SHR) and ICU and in-hospital mortality in patients with craniocerebral diseases and whether it was affected by pre-admission background glycemia compared to admission glucose. Methods In this retrospective study, the clinical data of 709 patients with craniocerebral diseases was drawn from the MIMIC-IV database. The study's main outcome was ICU and in-hospital mortality. All patients were further categorized by SHR tertiles. The associations between SHR and ICU and in-hospital mortality were assessed using multivariate logistic models, smooth curve fitting, and subgroup analysis. Results In multivariable analysis, SHR was positively associated with ICU and in-hospital mortality, with the OR increased stepwise from level 2 (ICU mortality, OR = 1.68, 95% CI: 0.74–3.83; in-hospital mortality, OR = 1.88, 95% CI: 0.99–3.57) to level 3 (ICU mortality, OR = 2.47, 95% CI: 1.12–5.45; in-hospital mortality, OR = 2.14, 95% CI: 1.13–4.04), referred to level 1. Based on smooth curve fitting, background blood glucose levels does not affect this relationship, which increased with SHR levels. In contrast, hyperglycemia at admission was only associated with clinical outcomes in patients without pre-admission background hyperglycemia. Conclusion SHR is an independent risk factor of ICU and in-hospital mortality in patients with craniocerebral diseases. Furthermore, compared to hyperglycemia on admission, background glycemia did not affect the relationship between SHR and mortality in the patients.
Material recognition method to enable adaptive drilling of multi-material aerospace stacks
Authors: HAOUA Abdoulaye Affadine , Rey Pierre-andre , Chérif Mehdi , Abisset Emmanuelle , Yousfi wadii 
Published: June 2023

Abstract

Multi-material stacks comprising composite and metallic layers are widely used in aerospace components. For the assembly of structural part high quality holes are required to ensure the performance of the mechanical fastening (rivet/bolt). On the final assembly lines of aircraft structures, these machining operations are often performed using electric Automated Drilling Unit (eADU). When drilling hybrid stacks, the difference in machinability of the materials (CFRP, titanium alloy and aluminum alloy) makes it difficult to avoid delamination, fiber pullout, matrix degradation, burrs, roughness and size defects. Therefore, each material must be drilled with suitable machining conditions to meet the demanding quality requirements. To this end, automated material detection would allow for the adjustment of appropriate cutting parameters for each material. Due to the numerous stack configurations (material, thickness) and the variability of process parameters (tool geometry, cutting conditions, lubrication, etc.), automated material detection is not an easy task. To address this issue in eADU applications, this paper presents a novel approach to identify during the process the drilled material being manufactured using a Random Forest (RF) machine learning model and multi-sensor data fusion. Cutting forces, vibration, micro-lubrication conditions (flow rate and pressure), and eADU spindle and feed motor currents are monitored on a dedicated drilling test rig. Numerous tests were performed on Al7175/CFRP stacks with different cutting conditions to validate the proposed methodology. Advanced signal processing and analysis in the time and frequency domains are used for feature extraction to identify Al7175 from the CFRP. The input features of the RF model were selected using the feature importance measure embedded in the RF model learning process. The knowledge process of drilling multiple material stacks is also considered. The results showed that the features extracted from the frequency domain are more effective in identifying the CFRP Al7175 than those extracted from the time domain. This optimal subset was then used to build the RF model. The proposed methodology resulted in a highly accurate classification allowing the implementation of an adaptive machining process on the eADU for hybrid stack drilling.
Associations between leisure-time physical activity level and peripheral immune cell populations in the US general population, analysis of the National Health and Nutrition Examination Survey data, 1999-2018
Authors: Lin Dan , Ba Djibril M. , Muscat Johusa E. , Zhou Shouhao , Rogers Connie J. , Sturgeon Kathleen M. 
Published: June 2023

Abstract
Background: Chronic levels of inflammation are associated with higher risk of many chronic diseases. Physical activity (PA) lowers the risk of cancer, cardiovascular disease (CVD), diabetes and others. One mechanism for PA-induced protection may be through the immune system. We investigated the association between leisure-time PA and peripheral immune cell populations in a large nationally representative sample of the US general population.
Methods: 17,093 participants (mean (SE) age of 41.6 (0.3) years) of the National Health and Nutrition Examination Survey 1999-2018 were included. Self-reported leisure-time PA was converted to metabolic equivalent of task hours per week (MET-hrs/wk). White blood cell (WBC) count, WBC ratios, and platelet count were derived. Multivariable linear regression analyses were used to estimate associations between leisure-time PA level and peripheral immune cell populations. Multivariable logistic regression analyses were used to estimate associations between leisure-time PA and metrics of WBC count and NLR which may predict mortality.
Results: A higher leisure-time PA level was associated with a lower WBC count (>14.0 vs. <1.2 MET-hrs/wk adjusted mean (95% confidence interval [CI]): 7.12 (6.86, 7.38) vs. 7.38 (7.12, 7.64) 1000 cells/μL, Ptrend <0.001) and a lower neutrophil-to-lymphocyte ratio (NLR; >14.0 vs. <1.2 MET-hrs/wk adjusted mean (95% CI): 2.04 (1.90, 2.18) vs. 2.13 (1.99, 2.28), Ptrend=0.007). Leisure-time PA level was not associated with lymphocyte-to-monocyte ratio (LMR; Ptrend=0.25) or platelet-to-lymphocyte ratio (PLR; Ptrend=0.69). Compared to the lowest leisure-time PA level (<1.2 MET-hrs/wk), the highest leisure-time PA level (≥14.0 MET-hrs/wk) was associated with a lower probability of a high WBC count (>8.1×109 cells; odds ratio [OR]=0.76, 95% CI=0.66-0.88) and high NLR (>2.68; OR=0.84, 95% CI=0.72-0.99), which may predict (CVD) and all-cause mortality. Compared to the lowest leisure-time PA level, the highest leisure-time PA level was associated with a lower probability of a high WBC count (≥8.3×109 cells/L; OR=0.76, 95% CI=0.66-0.88), which may predict cancer mortality.
Conclusions: We observed an inverse association between leisure-time PA level, WBC count, and NLR, particularly for neutrophil levels. These results suggest that participants at higher levels of leisure-time PA may have lower levels of inflammation, which may be important for future chronic disease outcomes.
Tri-stable Electrochromism with Passive Radiative Cooling for Year-Round Building Energy Saving
Authors: Cao Xun , Shao Zewei , huang Aibin , Cao Cuicui , Ji Xiaowei , Hu Wei , Luo Hongjie , Bell John , Jin Ping , Yang Ronggui 
Published: June 2023

Abstract

Building energy consumption for heating and cooling is a critical issue that has garnered wide attention due to its significant impact on global warming and sustainability. In particular, windows account for >20% of building energy loss. There is an urgent need for the independent optimization of thermal radiative properties of windows for tri-band radiation, including visible, near-infrared (NIR), and mid-infrared (MIR). Here we develop a new electrochromic structure for thermal management of windows, which is able to maximize the utilization of both solar radiation of visible and NIR light and radiative cooling of MIR light. We propose a tri-stable electrochromic device (ECD) based on the phase transitions of VO2 and WO3 films. The VO2-WO3 based ECD could realize three different optical states to independently regulate visible and NIR transmittance. Due to the decoupled barrier for opaque state in rutile LixVO2, our device also maintains non-volatility and tri-stability (<10% bleaching over 4 hours). Moreover, we introduce a new approach for thermal regulation by optimizing the emissivity of outside (εMIR-O of 0.79) and inside (εMIR-I of 0.33) electrodes to minimize radiative heat exchange between the indoor and outdoor environments. Outside experiments were performed in Sanya, China, realizing continuous all-day cooling of ~2-8 °C compared to low-e windows on a typical clear sunny day at Southern China latitudes. Simulation shows that this new ECD exhibits a higher heating and cooling energy savings than a commercial low-E glass in most climates around the world. Our findings render great opportunities for the innovative energy-saving window designs that can help achieve global carbon neutrality and sustainability.
Transcriptomic and metabolomic analyses reveal that ABA increases the salt tolerance of rice significantly correlated with jasmonic acid biosynthesis and flavonoid biosynthesis
Authors: Han Chunning , Chen Guanjie , Zheng Dianfeng , Feng Naijie 
Published: June 2023

Abstract
Abscisic acid (ABA) has been shown to mitigate the deleterious effects of abiotic stresses and to regulate plant growth and development. Salinity is one of the important abiotic stresses affecting plant cell metabolism and physiology, which causes serious damages to crops. In this study, we investigated the protective role of exogenous ABA on leaves in response to salinity stress using rice seedlings (two leaf-one heart) subjected to three treatments: ZCK (control), ZS (50 mM NaCl), and ZSA (5 mg/L ABA + 50 mM NaCl). We carried out transcriptomic and metabolomic analyses to identify the molecular mechanisms by which ABA protects plants against salt stress. Results showed that 1159 differentially expression genes (DEGs) (916 upregulated, 243 downregulated) and 63 differentially expression metabolites (DEMs) (42 upregulated, 21 downregulated) were identified between the ZS and ZSA treatments, respectively. In addition, ABA pretreatment regulated the expression pattern of genes responsible for oxidation redox, starch and sucrose metabolism, and phenylpropanoid biosynthesis. The combined transcriptomic and metabolomic analysis revealed that 16 DEGs and 2 DEMs were involved in Flavonoid biosynthesis and 8 DEGs and 2 DEMs were involved alpha-Linolenic acid metabolism which are responsible for salinity stress tolerance through induced by exogenous ABA. Overall, ABA could enhance rice leaves growth and development mainly by regulating flavonoid biosynthesis and linoleic acid metabolism pathway.