bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Sunrise Ultraviolet Spectropolarimeter and Imager: Standalone polarimetric calibration
Authors: Iglesias Francisco A. , Feller Alex , Gandorfer Achim , Riethmüller Tino L. , Korpi-Lagg Andreas , Solanki Sami K. , Katsukawa Yukio , Kubo Masahito , Toledo Mariano Sanchez 
Published: January 2025

Abstract

Sunrise is a 1-m optical solar observatory carried aloft by a stratospheric balloon. It was developed to study magnetic fields and plasma flows in the solar atmosphere with very high spatial resolution and sensitivity. The Sunrise UV Spectropolarimeter and Imager (SUSI) operates in the 309-417 nm range, covering thousands of spectral lines that are poorly accessible from the ground and largely unexplored. The instrument includes a dual-beam polarimeter based on a rotating waveplate, a polarization beam splitter and two custom-made CMOS cameras. SUSI gathers data at high spectral, spatial and temporal resolution. These data are stored onboard during flight. Given that SUSI does not include a polarimetric calibration unit onboard, its polarimetric demodulation matrix is estimated during laboratory calibration measurements prior to its flight. The quality of this calibration is crucial to accurately demodulate the data post-flight and reach the instrument's maximum polarimetric sensitivity goal of 1x10-3 of the continuum intensity. In this paper, we report the results of eighth polarimetric calibrations of SUSI standalone, acquired at six different wavelengths using artificial LED light sources. The field-dependant demodulation matrices obtained are within the values expected from the design, including their polarimetric efficiencies and temporal stability. The matrices are also confirmed to satisfy the calibration repeatability criterion imposed by the SUSI sensitivity goal.
Distribution and antimicrobial resistance of Acinetobacter spp. isolated from different types of infections from hospitalized patients and outpatients in Poland
Authors: Tomasz Kasperski , Monika Pobiega , Monika Pomorska-Wesołowska , Wiktoria Papuga , Agnieszka Chmielarczyk 
Published: January 2025

Abstract

Background:
Acinetobacter baumannii (AB) is the most frequently isolated nosocomial pathogen, but severe infections by A. pittii, A. ursingii, and A. bereziniaeare increasing. This study investigated the distribution and antibiotic resistance of Acinetobacter spp. strains from various infections.
Methods:
Data were collected between 2021–2023 from clinical samples of hospitalized and outpatient individuals in southern Poland. Strains were identified using MALDI-TOF Biotyper, and antibiotic susceptibility was tested with the MIDITECH-Analyzer system. Statistical analyses were conducted using IBM SPSS Statistics.
Results:
Among 1507 isolated Acinetobacter strains, 951 (63.1%) were AB, while 556 (36.9%) represented 27 non-AB species. Most isolates (73.6%) came from outpatients, while 26.4% were from hospitalized patients. A. ursingii (30.2%), A. pittii (20.6%), and A. junii(13%) were the most common non-AB species. A. bereziniae, A. calcoaceticus, and A. proteolyticus were more frequently found in hospitalized patients. Non-AB species dominated in/among genital tract infections (87%), whereas AB was more common in invasive infections. Nearly all strains were non-susceptible to ciprofloxacin (98.4%), with lower resistance rates to ampicillin/sulbactam (11.1%), trimethoprim/sulfamethoxazole (5.8%), gentamicin (2.9%), amikacin (2.5%), meropenem (1.6%), and colistin (1.6%). A. bereziniae showed frequently resistance to carbapenems, aminoglycosides, and trimethoprim/sulfamethoxazole. Colistin resistance was observed in A. ursingii and A. pittii.
Conclusions:
While AB accounted for 63.1% of isolates, non-AB species were common, particularly in genitourinary and skin infections. Emerging hospital-acquired infections by species like A. pittii underline the need for vigilant monitoring. The high resistance to ciprofloxacin and low but noticeable resistance to carbapenems and colistin highlights the importance of early detection and resistance surveillance to prevent the spread of resistant strains.
Dimensions And Challenges Associated With Mental Health Support Groups In Zambia: A Service Provider Perspective
Authors: Mulungu Choongo , Shawa Jackson , Matongo Evelyn Mwangala 
Published: January 2025

Abstract

Introduction: The burgeoning impact of mental illness over the last two decades underscores a global health crisis, exacerbated by disparities faced by ethnic minorities in accessing quality care. Mental health challenges pose a significant burden on individuals, families, and the Zambian healthcare system. While significant advances have been made around mental health, there is still a significant bias towards pharmacological and counselling interventions while hardly prescribing support groups. This study sought to investigate the landscape of mental health support groups in Zambia by understanding the dimensions and challenges faced by facilitators.
Materials and Methods: This was a mixed methodology study employing explanatory sequential design in which quantitative data will be sought first and supported by qualitative findings. The study involved 23 support groups facilitators majority (12 respondents) of whom were males.
Results: The study found that support groups for mental health operate in private premises and institutions while other groups operate a hybrid of physical and virtual and others are completely virtual. Majority of the groups are organized by psychologists followed by non-medical facilitators who previously had mental disorders and felt the need to support others. Further, all facilitators had no competency specific for facilitating mental health support groups. Lack of financial support, general infrastructure and space for meetings, and network connectivity were challenges faced by facilitators while noting awareness and stigma reduction, recovery prognosis and improved service uptake as opportunities associated with effective mental health support groups.
Conclusion: The study concludes that existing mental health support groups operating in community-based settings as well as hospitals are a resource for patients, facilitators, and health systems provided they are supported and staff are trained on facilitation.
Financial Development and Economic Growth Nexus in Nigeria: A Cointegration Analysis
Authors: Lawal Dolapo Temitayo 
Published: January 2025

Abstract

This paper examines the short-run and long-run relationship between financial development and economic growth in Nigeria. After performing cointegration tests, the study estimates error correction models of economic growth on financial development using the autoregressive distributed lag (ARDL) and the nonlinear autoregressive distributed lag (NARDL) approach. The NARDL modelling approach accounts for possible asymmetries in financial development. The study also estimates a vector error correction model with exogenous variables (VECM-X) to observe the relationship in the presence of endogeneity between financial development and economic growth. Annual data on Nigeria’s real gross domestic product is used as a proxy for economic growth, and the financial development index computed by the International Monetary Fund is employed as a proxy for financial development from 1981 to 2020. The Bounds and Johansen cointegration tests show a long-run relationship in the three models. Furthermore, the negative signs and magnitude of the coefficients of the error correction terms suggest mean reversion in all the models. While the study finds cointegration among the variables in all the models, the financial development index is insignificant in the long run and often negatively relates to the real gross domestic product. This paper concludes that financial development does not significantly lead to growth in the real sector, especially in the long run.
JEL Classification: C32, E44, O15, O47
Causal pathways from sustainable practices to economic stability through food security: An SEM approach
Authors: Woudneh Awoke Fetahi 
Published: January 2025

Abstract

Introduction:This study investigates the complex interplay between sustainable agricultural practices, food security, and economic stability through structural equation modeling (SEM). It seeks to elucidate how different farming practices impact food security and, in turn, economic stability, while considering the influence of socio-demographic and regional factors.
Methods:Using SEM, we analyzed data on sustainable agricultural practices, food security metrics, and economic stability indicators. The model accounted for variables such as crop types, educational attainment, and regional factors, including geographic location and climate. Despite some concerns regarding data quality, the model fit indices demonstrated that the model performed adequately.
Results:The findings reveal that food security exerts a robust positive effect on economic stability. Among sustainable agricultural practices, organic farming and conservation tillage were particularly effective in enhancing food security, while agroforestry showed less consistent results. Socio-demographic factors, such as education level and gender, as well as regional factors like climate and geographic location, significantly influenced both food security and economic stability.
Conclusion:This research underscores the pivotal role of food security in promoting economic stability and highlights the advantages of adopting sustainable agricultural practices. Organic farming and conservation tillage are shown to have significant positive effects on food security, although agroforestry's impact is variable. Additionally, socio-demographic and regional factors play a critical role in shaping food security and economic outcomes. These insights are valuable for policymakers and practitioners aiming to enhance agricultural productivity and economic resilience.
DETERMINANT FACTORS OF FINANCIAL REPORTING QUALITY IN LOCAL GOVERNMENT: THE EVIDENCE FROM PUBLIC SECTOR IN INDONESIA
Authors: Prawati Levana Dhia , Murwaningsari Etty 
Published: January 2025

This study aims to examine the effects of spending plan composition elements, regional wealth, local government features, and the characteristics of regional government leaders on the quality of local government financial reports in Indonesia, as well as the moderating effect of financial performance. The research utilized Multinomial Logistic Regression with Pooled Data for hypothesis testing. This analysis draws on 1089 Regional Government Financial Reports from around Indonesia in 2021-2023.We utilize the audit opinion type as an indicator of reporting quality, where an unqualified opinion signifies the highest level of quality, and a disclaimer of opinion indicates the lowest quality. Two ratios were developed based on the financial budget by local government to measure financial performance, which are the Routine Ability Index Ratio (RAIR) and Budget Effectiveness Ratio (BER). The findings of this study, the regional wealth factor, and the proficiency of regional government officials affect the quality of regional financial reporting (FRQ). This research has implications for central government policies in examining the quality of regional financial reporting. The first implication of this study reveals that the wealthier a regional government is, the higher the quality of its financial reporting tends to be. Second, a leader’s years of experience in governing a region influence the quality of his regional financial report. This implies a longer leadership period influences better performance.
Exploring the Intricacies of Polycystic Ovarian Syndrome (PCOS): A Comprehensive Review-from Prevalence to Natural Solutions
Authors: Soni Priyanka , Jain Divya , Bhatti Manisha , Bhatia Deepika , Sharma chandan 
Published: January 2025

Introduction:
Among women of reproductive age, Polycystic Ovarian Syndrome (PCOS) is a common endocrine condition marked by insulin resistance,
metabolic abnormalities, and hormonal imbalances. Infertility, irregular menstrual periods, acne, hirsutism, and obesity are among the symptoms
that this illness frequently causes. Traditional PCOS therapies usually include drugs like insulin sensitizers and oral contraceptives, which can have
negative side effects and might not deal with the underlying causes of the condition. This study aims to examine the etiology of PCOS and the
effectiveness of natural management techniques in reducing symptoms and enhancing general health outcomes.

Aims and Objective:
The objective of this study is to comprehend the pathophysiology and underlying mechanisms of PCOS, including hormonal and metabolic factors,
assess the effectiveness of natural management strategies, such as dietary changes, herbal supplements, physical activity, and lifestyle
interventions, in managing symptoms, investigate the effects of particular diets and lifestyle changes on insulin sensitivity, inflammation, and
hormonal balance in PCOS patients, compare natural strategies with conventional treatments to determine the advantages and disadvantages of
each treatment, identify research gaps, and suggest areas for future study.

Methodology:
A thorough examination of pertinent literature, including clinical studies, randomized controlled trials, and meta-analyses published in peerreviewed
journals, was a part of the search approach. Studies on the pathophysiology of PCOS, traditional therapies, and natural management
strategies were found using databases like PubMed, Scopus, and Web of Science.

Results:
The review concentrated on studies conducted within the last 15 years to guarantee that the most recent findings were included. This study intends
to shed light on the possible advantages of incorporating natural methods into PCOS care by combining the available data and comprehensive
treatment choices.

Conclusion:
In summary, PCOS is a common and complex disorder that affects women's health worldwide. Effective management requires knowledge of its
symptoms, risk factors, and underlying mechanisms. Women can be empowered to manage PCOS better and enhance their general well-being by
emphasizing a holistic approach that incorporates lifestyle changes and natural therapies.
Use of SGLT2 Inhibitors in Frail Older Adults is Associated with Increased Survival: A Retrospective Study
Authors: Ragusa Francesco Saverio , Veronese Nicola , Ciriminna Stefano , Agnello Diletta , Capitummino Rosella , Cavaleri Chiara , D’Aleo Alessandro , Errera Chiara Maria , Garlisi Maria Chiara , Giannettino Chiara , Nigro Alessandra Lo , Lampo Sofia Elena Montana , Plano Ottavia Giovanna , Speziale Gerlando , Titone Pascal Roberto , Barbagallo Mario , Dominguez Ligia J. 
Published: January 2025

Background:
In recent years, sodium-glucose co-transporter 2 inhibitors (SGLT2i) have emerged
as a valuable treatment for type 2 diabetes (T2D) and heart failure. Despite these medications seeming to be
safe in older people, the literature about SGLT2i and frailty is still limited. This study aims to evaluate
whether SGLT2i use is associated with increased survival in older adults and if frailty can affect the findings.

Material and Methods:
We enrolled over 65 patients admitted to the Geriatrics Wards at the University Hospital
'P. Giaccone' in Palermo, Italy, between December 2022 and May 2023. After 12 months of follow-up, various
outcomes were assessed, including mortality, hospitalization, glycemic dysregulation, urinary tract infections,
and falls. The association between SGLT2i use and mortality was analyzed and reported as hazard ratios
(HRs) with their 95% confidence intervals (CIs).

Results:
A total of 80 patients were included in the study (mean age 79.5 ± 8.5 years; 50% were women). Patients
using SGLT2i had a higher prevalence of T2D (p = 0.02) and cirrhosis (p = 0.001). After adjusting for
potential confounders, SGLT2i use was significantly associated with a reduced mortality risk (HR = 0.53;
95% CI: 0.20-0.93; p = 0.02). When stratified by the presence of multidimensional frailty, SGLT2i use was
significantly associated with a lower risk of mortality in frail patients (HR = 0.27; 95% CI: 0.06-0.88; p =
0.008), but not in robust ones.

Conclusion:
In older frail patients, the use of SGLT2i is associated with reduced mortality after 12 months of
follow-up. Further larger studies are needed to evaluate the role of these medications in older adults.
Mechanism Analysis of the Effect of Cordycepin on Colorectal Cancer via Network Pharmacology and Experiment
Authors: Chen Ya , Wang Peng , Zhang Mingzhu , Yang Hao , Liang Beibei 
Published: January 2025

Objective:
Colorectal Cancer (CRC) has attracted much attention due to its high mortality
and morbidity. Cordycepin, also known as 3'-deoxyadenosine (3'-dA), exhibits many biological
functions, including antibacterial, anti-inflammatory, antiviral, anti-tumor, and immunomodulatory
effects. It has been proven to show anticancer activity in both laboratory research
studies and living organisms. However, the molecular mechanism of the effect of cordycepin on
CRC remains unclear.

Methods:
The genes associated with cordycepin and colorectal cancer have been identified by
comparing the toxicogenomics database (CTD) and GeneCards database. The common genes between
cordycepin and CRC have been identified using the Venny tool. The Protein-protein Interaction
(PPI) network has been drawn using the STRING database. GO and KEGG enrichment
analyses of the intersecting genes have been followed by experimental validation, both in vitro
and in vivo.

Results:
24 drug targets have been screened using the CTD database and 1490 disease targets
have been obtained from the GeneCards database and GO and KEGG analyses. The effect of
cordycepin on the proliferation of SW480 cells has been assessed using CCK-8. The related results
have indicated cordycepin to inhibit the proliferation of SW480 cells, promote apoptosis,
and activate the p53 signal pathway. The findings obtained from in vivo experiments have been
found to be consistent with those obtained from in vitro studies.

Conclusion:
Our findings have elucidated an effective way to search for cordycepin’s potential
mechanism of effect on CRC therapy by employing the network pharmacology and experiment.
We have predicted that cordycepin can inhibit tumor growth by regulating the apoptosis pathway.
This study has offered valuable insights into the potential mechanism of the effect of
cordycepin on CRC and provided a theoretical basis for further validation of its clinical application.

result:
A total of 24 drug targets were screened using the CTD database, and 1490 disease targets were obtained from the GeneCards database, and GO and KEGG analysis. The impact of cordycepin on the proliferation of SW480 cells was assessed using Cell Counting Kit-8 (CCK-8). The apoptosis rate was detected using flow cytometry. RT-qPCR and Western blotting were used to detect the expression levels of related proteins. The results indicate that cordycepin inhibited the proliferation of SW480 cells, promoted apoptosis, and activated p53 singnal pathway. The findings from in vivo experiments were consistent with those from in vitro studies.
Conformation Study and Design of Novel 6-Hydroxybenzothiazole-2-Carboxamides as Potentially Potent and Selective Monoamine Oxidase B Inhibitors for Neuroprotection
Authors: Xie Dong , Guo Penghang , Zhao Quantang , Gao Yu , Zhang Jianan , Zhou Jie 
Published: January 2025

Background:
6-hydroxybenzothiazole-2-carboxamide is a novel, potent, and specific
monoamine oxidase B inhibitor that can be used to study the structure of molecules and come up
with new ways to protect neurons.

Objective:
The objective of this work was to create an effective model using derivatives of 6-
hydroxybenzothiazole-2-carboxamide and establish a dependable predictive foundation for the
development of neuroprotective monoamine oxidase B inhibitors for the treatment of neurodegenerative
diseases.

Methods:
The construction and optimization of all compounds were carried out sequentially using
ChemDraw software and Sybyl-X software. The optimized compounds were further analyzed
using the COMSIA approach and the Sybyl-X software tool for QSAR modeling. A set of novel
compounds of 6-hydroxybenzothiazole-2-carboxamide were created and their IC50 values were
forecasted using QSAR modeling. Ultimately, the recently developed compounds underwent a
screening process using their IC50 values, and molecular docking tests were conducted on the
ten most promising compounds with the highest IC50 values.

Results:
The 3D-QSAR model exhibited favorable outcomes. The value of q2 in the COMSIA
model was 0.569. The model demonstrated a superior r2 value of 0.915, a lower SEE of 0.109,
and a higher F-value of 52.714. The statistical findings and validation of the model were deemed
adequate. Furthermore, analyzing the contour plots might assist in identifying the necessary
structural specifications.

Conclusion:
This work has the potential to provide an insight into the development of active
medicines that protect the nervous system against neurodegenerative disorders.
The Dorsolateral Prefrontal Cortex: A High-level Hub for Allostatic Cardiovascular Control
Authors: Marcinkowska Anna B. , Kucewicz Michał T. , Szarmach Arkadiusz , Winklewski Paweł J. 
Published: January 2025

Abstract:
The dorsolateral prefrontal cortex (dlPFC) is increasingly targeted by various noninvasive
transcranial magnetic stimulation or transcranial current stimulation protocols in a range of
neuropsychiatric and other brain disorders. The rationale for this therapeutic modulation remains
elusive. A model is proposed, and up-to-date evidence is discussed, suggesting that the dlPFC is a
high-level cortical centre where uncertainty management, movement facilitation, and cardiovascular
control processes are intertwined and integrated to deliver optimal behavioural responses in particular
environmental or emotional contexts. A summary of the state-of-the-art in the field is provided to
accelerate the development of emerging neuromodulation technologies for brain stimulation and recording
for patients with mood, sleep, and cognitive disorders in our ageing population.