bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspectives and sentiments on contingency management from people who use methamphetamine
Authors: Clay Simon , Wilkinson Zachary , Ginley Meredith , Arunogiri Shalini , Christmass Michael , Membrey Dean , MacCartney Paul , Sutherland Rachel , Colledge‐Frisby Samantha , Marshall Alison D. , Nagle Jack , Degenhardt Louisa , Farrell Michael , McKetin Rebecca 
Published: May 2023

AbstractIntroductionContingency management (CM) is currently the most efficacious treatment for methamphetamine use, yet it is rarely available in routine care. We examined the viewpoints of people who use methamphetamine on CM as a potential treatment for methamphetamine use disorder.MethodsSemi‐structured qualitative interviews with 30 Australians aged 18 years or older who had used methamphetamine at least weekly in the past 6 months.ResultsParticipants reported overall positive attitudes towards CM as a potential treatment option for methamphetamine use disorder. However, there was need for greater flexibility in meeting participant treatment goals (e.g., reduced use or complete abstinence), with particular concern about the viability of initiating abstinence, both in terms of the sufficiency of the initial financial incentive and managing withdrawal symptoms. There was strong interest in the use of digital technologies to provide remote CM, particularly around the convenience and flexibility this offered. Despite this, participants remained keen to access adjunctive treatment and support services but stressed that engagement with these additional services should not be mandatory. Marketing of CM will need to address preconceptions about drug‐testing used in abstinence‐based CM being punitive (especially urine testing) and its connotations with criminal justice interventions.Discussion and ConclusionPositive attitudes towards CM bode well for potential uptake should CM be made available in routine clinical practice. However, there is a need to adapt CM to ensure it is feasible and attractive to people who are seeking treatment for methamphetamine use disorder.
Following social media influencers who share alcohol‐related content is associated with college drinking
Authors: Strowger Megan , Ayala Guzman Rachel , Geyer Rachel B. , Ward Rose Marie , Braitman Abby L. 
Published: May 2023

AbstractIntroductionFrequent exposure to peer‐shared alcohol‐related content (ARC) on social media is associated with greater alcohol consumption and related consequences among undergraduates. Social media influencers also share ARC; yet, the effect of exposure to influencer‐shared ARC on alcohol outcomes has not been examined. The current study examined whether following influencers who share ARC and the frequency of sharing were associated with alcohol outcomes, and associations between influencer type (e.g., actors) and alcohol outcomes.MethodsUndergraduates (N = 528) from two universities in the United States completed an online survey assessing demographics, social media use, alcohol use and related consequences. They listed up to five influencers they followed and viewed the most content from. A series of linear regression models were conducted.ResultsHaving a larger proportion of influencers sharing ARC was associated with greater quantity, frequency and peak drinks, but not consequences. Frequency of influencers sharing ARC was associated with greater quantity and peak drinks, but not frequency or consequences. Findings remained significant, even after controlling for peer ARC. Actor ARC, everyday person ARC and ‘other’ type influencer ARC were associated with several alcohol outcomes.Discussion and ConclusionsThis study added to the literature by examining how following influencers who share ARC, and sharing frequency, were associated with drinking outcomes over and above exposure to peer ARC. It also examined whether ARC content from specific types of influencers was associated with alcohol outcomes. Findings highlight that the source of ARC is relevant when studying the effects of ARC exposure on college drinking.
Data‐driven fault diagnosis approaches for industrial equipment: A review
Authors: Sahu Atma Ram , Palei Sanjay Kumar , Mishra Aishwarya 
Published: May 2023

AbstractUndetected and unpredicted faults in heavy industrial machines/equipment can lead to unwanted failures. Therefore, prediction of faults puts paramount importance on maintaining the reliability and availability of capital‐intensive equipment. Due to large number of interconnected and interdependent mechanical and electrical components in the machines, fault analysis becomes a complex and challenging task. Under these circumstances, data‐driven fault diagnosis (DDFD) is one of the most powerful, reliable and cost‐effective artificial intelligence tools to detect, isolate, identify and classify the occurrence of faults. This article aims to make a comprehensive literature survey of various DDFD approaches used for analysing faults in industrial machines/equipment; and summarizing the strengths, limitations, and possible applications of existing fault diagnosis methods. Analysing and synthesizing 190 research works conducted on DDFD in last two decades revealed three types of DDFD approaches: supervised‐learning, semi‐supervised‐learning and unsupervised‐learning‐based fault diagnosis. The supervised‐learning is predominantly applied for fault diagnosis contributing to 82% of research works. Therefore, this article puts special emphasis on two supervised‐learning‐based approaches for fault diagnosis: (i) classification‐based artificial neural network approach, and (ii) inference‐based Bayesian network approach. Finally, these fault diagnosis approaches have been briefly discussed with effectiveness of the models and their possible inclusion in future industrial applications.
The prediction of two‐dimensional intelligent ocean temperature based on deep learning
Authors: Wu Zichen , He Jingyi , Hu Siyuan , Wen Jiabao 
Published: May 2023

AbstractAn important data in intelligent ocean is the sea surface temperature (SST). Most of the previous works on SST prediction deal with independent spatial point, ignoring the spatial correlation of two‐dimensional intelligent ocean, which leads to instability of prediction accuracy. Therefore, in this paper, a deep learning model based on convolutional gated recurrent unit is proposed for the SST prediction of two‐dimensional intelligent ocean. Input and output of the proposed model are both spatiotemporal SST data, which means the model directly process spatiotemporal data. This method adds the spatial information of the intelligent ocean temperature data, thereby improving the accuracy. From the experiments, it turns out that the proposed model shows superior performance compared to another three prevailing deep learning models.
Squamous cell carcinoma‐derived G‐CSF promotes tumor growth and metastasis in mice through neutrophil recruitment and tumor cell proliferation, associated with poor prognosis of the patients
Authors: Kemuriyama Kohei , An Jianbo , Motoyama Satoru , Nagaki Yushi , Yamaguchi Tomokazu , Sato Yusuke , Wakita Akiyuki , Minamiya Yoshihiro , Kuba Keiji 
Published: May 2023

AbstractTumor‐derived G‐CSF is a well‐known factor to aggravate disease progression in various types of cancers. In this study, we investigated a role of G‐CSF in squamous cell carcinoma (SCC). High expression of G‐CSF in the tumor tissues of esophageal SCC (ESCC) patients correlated with poor prognosis. Murine SCC NR‐S1M cells produce considerable amount of G‐CSF, which expression is correlated with its metastatic potentials. Deletion of G‐CSF in NR‐S1M cells mitigated tumor growth and metastasis to lymph node and lung of subcutaneous NR‐S1M tumors in the mice. Mechanistically, G‐CSF enhanced cell proliferation in autocrine manner in vitro, whereas in NR‐S1M tumor‐bearing mice, accumulation of plasma G‐CSF was associated with expansion of peripheral neutrophils, which led to a decreased proportion of CD8+ T cells. Antibody depletion of neutrophils restored the number of CD8+ T cells and modestly suppressed tumor outgrowth, albeit no changes in distant metastasis. We propose that G‐CSF produced by NR‐S1M cells facilitates tumor progression in mice through bi‐functional effects to promote neutrophil recruitment and tumor cell proliferation, which may render poor prognosis to the ESCC patients with high G‐CSF expression.
A focus on dominant negative variants in a series of 170 heterozygous FXI‐deficient patients
Authors: de Mazancourt Philippe , Quélin Florence , Flaujac Claire , de Raucourt Emmanuelle , Guillet Benoît , Bauduer Frédéric , Ernest Vincent , Beurrier Philippe , Avril Aurélie , d'Oiron Roseline , Biron‐Andréani Christine , Meunier Sandrine , Dargaud Yesim 
Published: May 2023

AbstractIntroductionDominant‐negative effects have been described for 10 F11 variants in the literature.AimThe current study aimed at identifying putative dominant‐negative F11 variants.Material and methodsThis research consisted in a retrospective analysis of routine laboratory data.ResultsIn a series of 170 patients with moderate/mild factor XI (FXI) deficiencies, we identified heterozygous carriers of previously reported dominant‐negative variants (p.Ser243Phe, p.Cys416Tyr, and p.Gly418Val) with FXI activities inconsistent with a dominant‐negative effect. Our findings also do not support a dominant‐negative effect of p.Gly418Ala. We also identified a set of patients carrying heterozygous variants, among which five out of 11 are novel, with FXI activities suggesting a dominant‐negative effect (p.His53Tyr, p.Cys110Gly, p.Cys140Tyr, p.Glu245Lys, p.Trp246Cys, p.Glu315Lys, p.Ile421Thr, p.Trp425Cys, p.Glu565Lys, p.Thr593Met, and p.Trp617Ter). However, for all but two of these variants, individuals with close to half normal FXI coagulant activity (FXI:C) were identified, indicating an inconstant dominant effect.ConclusionOur data show that for some F11 variants recognized has having dominant‐negative effects, such effects actually do not occur in many individuals. The present data suggest that for these patients, the intracellular quality control mechanisms eliminate the variant monomeric polypeptide before homodimer assembly, thereby allowing only the wild‐type homodimer to assemble and resulting in half normal activities. In contrast, in patients with markedly decreased activities, some mutant polypeptides might escape this first quality control. In turn, assembly of heterodimeric molecules as well as mutant homodimers would result in activities closer to 1:4 of FXI:C normal range.
Ecological and life‐history traits predict temporal trends in biomass of boreal moths
Authors: Yazdanian Mahtab , Kankaanpää Tuomas , Itämies Juhani , Leinonen Reima , Merckx Thomas , Pöyry Juha , Sihvonen Pasi , Suuronen Anna , Välimäki Panu , Kivelä Sami M. 
Published: May 2023

Abstract
Dramatic insect declines, and their consequences for ecosystems globally, have received considerable attention recently. Yet, it is still poorly known if ecological and life‐history traits can explain declines and whether insect decline occurs also at high latitudes. Insects' diversity and abundance are dramatically lower at high latitudes compared to the tropics, and insects might benefit from climate warming in high‐latitude environments.
We adopted a trait‐ and biomass‐based approach to estimate temporal change between 1993 and 2019 in Finnish macro‐moth communities by using data from 85 long‐running light traps. We analysed spatio‐temporal variation in biomass of moth functional groups with Joint Dynamic Species Distribution Models while accounting for environmental variables.
We did not detect any declining trends in total moth biomass of moth functional groups, and most groups were stable over time. Moreover, biomass increased for species using coniferous trees, lichens, or mushrooms as hosts, multivoltine species, as well as monophagous and oligophagous species feeding on trees. We found that length and temperature of the growing season, winter climatic conditions, and habitat structure all partially explained variation in moth biomass.
Although boreal moth communities are rapidly changing due to species turnover, in terms of total biomass they seem to contradict the trend of dramatic insect declines observed globally. This may lessen the immediate possibility of negative bottom‐up trophic cascades in boreal food webs.
What drives unhappiness? A cross‐country analysis
Authors: Acosta‐González H. Nicolás , Marcenaro‐Gutiérrez Oscar D. 
Published: May 2023

AbstractWe study the sources of misery (lowest level of life satisfaction) using the European Quality of Life 2016, a cross‐sectional survey for 28 European Union countries. We use the decomposition of misery, multivariate analysis and a structural equation model to assess which are the main sources to explain misery: risk of depression (mental health), unemployment, poverty or chronic health problems (physical health). Regardless of the methodological approach followed, we found consistently that the effect of mental health on misery is the largest, exceeding poverty and unemployment. Nonetheless, stigma and low access are the main barriers for mental health attention; therefore, policy goals should proactively promote attention, efficient prevention and early diagnosis of mental health problems.
The dispersal patterns of a migratory insect are driven by biotic interactions
Authors: Nuñez‐Penichet Claudia , Soberón Jorge , Osorio‐Olvera Luis 
Published: May 2023

AbstractAimThe distribution of a species in an area depends on the presence of suitable climatic conditions, suitable biotic interactions and species dispersal capabilities. Studies of species migration usually do not include all these factors due to a lack of detailed ecological information or appropriate methods. Here, we present simulations that consider all those factors for the study of the migratory patterns ofUrania boisduvaliiby incorporating environmental suitability, biotic interactions with its host plants (Omphaleaspp.), and the moth dispersal capacity.LocationCuba.TaxonUraniaandOmphalea.MethodsOur approach considers changes in the palatability of plants resulting from foraging by moths, as the novel mechanism driving their dispersal. Here, the state of each cell is determined by climate, dispersal, presence of edible food plants and change in food plant palatability.ResultsUraniadispersal occurs among sites with both edible food plants and suitable climates within the dispersal capacity of the moths. The number of isolated clusters of suitable patches decreased with larger dispersal capacities. All simulations where the palatability recovery is faster than palatability loss, lead to an oscillatory pattern of a local nature, while the other ones lead to a steady occupancy or extirpation of the moth species.Main ConclusionsOur results provide theoretical support for the hypothesis that the palatability of food plants drives the pattern of movement of the moths and predict that the relationship between toxic and non‐toxic periods is critical to determining steady occupancy, oscillatory occupancy or extirpation of the moth from the host plant patches. The conceptual framework we used is directly based on classic literature and the methods we used are implemented as an R package. Therefore, our approach is suited to model, in a practical way, invasive species, emerging diseases or migratory species.
An inflammation‐associated ferroptosis signature optimizes the diagnosis, prognosis evaluation and immunotherapy options in hepatocellular carcinoma
Authors: Ruan Wan‐Yuan , Zhang Lu , Lei Shan , Zeng Zhi‐Rui , Yang Yu‐Shi , Cao Wen‐Peng , Hao Qiu‐Yao , Lu Min , Tian Xiao‐Bin , Peng Pai‐Lan 
Published: May 2023

AbstractInflammation and ferroptosis crosstalk complexly with immune microenvironment of hepatocellular carcinoma (HCC), thus affecting the efficacy of immunotherapy. Herein, our aim was to identify the inflammation‐associated ferroptosis (IAF) biomarkers for contributing HCC. A total of 224 intersecting DEGs identified from different inflammation‐ and ferroptosis‐subtypes were set as IAF genes. Seven of them including ADH4, APOA5, CFHR3, CXCL8, FTCD, G6PD and PON1 were used for construction of a risk model which classified HCC patients into two groups (high and low risk). HCC patients in the high‐risk group exhibited shorter survival rate and higher immune score, and were predicted to have higher respond rate in immune checkpoint inhibition (ICI) therapy. Levels of the seven genes were significantly changed in HCC tissues in comparison to adjacent tissues. After inserting the gene expression into the risk model, we found that the risk model exhibited the higher diagnostic value for distinguish HCC tissues compared each single gene. Furthermore, HCC tissues from our research group with high‐risk score exhibited more cases of microsatellite instability (MSI), heavier tumour mutational burden (TMB), higher expression level of PDL1 and cells with CD8. Knockdown of APOA5 reduced HCC cell proliferation combining with elevating inflammation and ferroptosis levels. In conclusion, we considered APOA5 maybe a novel target for suppressing HCC via simultaneously elevating inflammation and ferroptosis levels, and signature constructed by seven IAF genes including ADH4, APOA5, CFHR3, CXCL8, FTCD, G6PD and PON1 can act as a biomarker for optimising the diagnosis, prognosis evaluation and immunotherapy options in HCC patients.
Resocializing recordings: Collaborative archiving and curating of sound as an agent of knowledge transfer
Authors: Lewy Matthias , Brabec Bernd 
Published: May 2023

AbstractThe authors discuss their methodologies for creating and relistening to recordings in collaboration with Indigenous People in Peru and Venezuela and contextualize them within the discourse about overcoming power structures that shape divides between the Global North and South, in both urban and rural trajectories, and in Western and Indigenous knowledges. When it comes to giving back or sharing sound recordings, we suggest the term resocialization rather than restitution or repatriation. In Indigenous lifeworlds, sound works much differently than in modern conceptualizations of music as art or entertainment. Indigenous theories of sound complement frameworks of copyright, which are still mainly based on modern views of human creativity. Working in archives and exhibitions, we seek collaboration with Indigenous experts when archiving, publishing, displaying, or playing recordings. We show how Indigenous and European specialists can foster eye‐level bilateral knowledge transfer by fruitfully cocurating sound and multimedia installations in exhibition contexts.
Proposal of early CT morphological criteria for response of liver metastases to systemic treatments in gastroenteropancreatic neuroendocrine tumors: Alternatives to RECIST
Authors: de Mestier Louis , Resche‐Rigon Matthieu , Dromain Clarisse , Lamarca Angela , La Salvia Anna , de Baker Lesley , Fehrenbach Uli , Pusceddu Sara , Colao Annamaria , Borbath Ivan , de Haas Robbert , Rinzivillo Maria , Zerbi Alessandro , Funicelli Luigi , de Herder Wouter W. , Selberherr Andreas , Wagner Anna Dorothea , Manoharan Prakash , De Cima Andrea , Lybaert Willem , Jann Henning , Prinzi Natalie , Faggiano Antongiulio , Annet Laurence , Walenkamp Annemiek , Panzuto Francesco , Pedicini Vittorio , Pitoni Maria Giovanna , Siebenhuener Alexander , Mayerhoefer Marius E. , Ruszniewski Philippe , Vullierme Marie‐Pierre 
Published: May 2023

AbstractRECIST 1.1 criteria are commonly used with computed tomography (CT) to evaluate the efficacy of systemic treatments in patients with neuroendocrine tumors (NETs) and liver metastases (LMs), but their relevance is questioned in this setting. We aimed to explore alternative criteria using different numbers of measured LMs and thresholds of size and density variation. We retrospectively studied patients with advanced pancreatic or small intestine NETs with LMs, treated with systemic treatment in the first‐and/or second‐line, without early progression, in 14 European expert centers. We compared time to treatment failure (TTF) between responders and non‐responders according to various criteria defined by 0%, 10%, 20% or 30% decrease in the sum of LM size, and/or by 10%, 15% or 20% decrease in LM density, measured on two, three or five LMs, on baseline (≤1 month before treatment initiation) and first revaluation (≤6 months) contrast‐enhanced CT scans. Multivariable Cox proportional hazard models were performed to adjust the association between response criteria and TTF on prognostic factors. We included 129 systemic treatments (long‐acting somatostatin analogs 41.9%, chemotherapy 26.4%, targeted therapies 31.8%), administered as first‐line (53.5%) or second‐line therapies (46.5%) in 91 patients. A decrease ≥10% in the size of three LMs was the response criterion that best predicted prolonged TTF, with significance at multivariable analysis (HR 1.90; 95% CI: 1.06–3.40; p = .03). Conversely, response defined by RECIST 1.1 did not predict prolonged TTF (p = .91), and neither did criteria based on changes in LM density. A ≥10% decrease in size of three LMs could be a more clinically relevant criterion than the current 30% threshold utilized by RECIST 1.1 for the evaluation of treatment efficacy in patients with advanced NETs. Its implementation in clinical trials is mandatory for prospective validation. Criteria based on changes in LM density were not predictive of treatment efficacy.Clinical Trial RegistrationRegistered at CNIL‐CERB, Assistance publique hopitaux de Paris as “E‐NETNET‐L‐E‐CT” July 2018. No number was assigned. Approved by the Medical Ethics Review Board of University Medical Center Groningen.
A revised terminology for the pharyngeal arches and the arch arteries
Authors: Graham Anthony , Hikspoors Jill P. J. M. , Anderson Robert H. , Lamers Wouter H. , Bamforth Simon D. 
Published: May 2023

AbstractThe pharyngeal arches are a series of bulges found on the lateral surface of the head of vertebrate embryos. In humans, and other amniotes, there are five pharyngeal arches and traditionally these have been labelled from cranial to caudal—1, 2, 3, 4 and 6. This numbering is odd—there is no ‘5’. Two reasons have been given for this. One is that during development, a ‘fifth’ arch forms transiently but is not fully realised. The second is that this numbering fits with the evolutionary history of the pharyngeal arches. Recent studies, however, have shown that neither of these justifications have basis. The traditional labelling is problematic as it causes confusion to those trying to understand the development of the pharyngeal arches. In particular, it creates difficulties in the field of congenital cardiac malformations, where it is common to find congenital cardiac lesions interpreted on the basis of persistence of the postulated arteries of the fifth arch. To resolve these problems and to take account of the recent studies that have clarified pharyngeal arch development, we propose a new terminology for the pharyngeal arches. In this revised scheme, the pharyngeal arches are to be labelled as follows—the first, most cranial, the mandibular (M), the second, the hyoid (H), the third, the carotid (C), the fourth, the aortic (A) and the last, most caudal, the pulmonary (P).