bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aspects of elastic deformation and nanomaterials past a deviating cone and wedge elongational surfaces driven by a waste discharge concentration
Authors: Vinutha Kalleshachar , Srilatha Pudhari , Zaib Aurang , Madhukesh Javali Kotresh , Khan Umair , Hassan Mehboob Ul 
Published: January 2025

AbstractThis existing work has several beneficial advantages in science and engineering including developing more efficient cooling systems, elastic deformation has a substantial application in the ceramic foam and plastic industries. Environmental applications require waste discharge concentration through a different geometry (Cone and Wedge). The current article examines the influence of a magnetic field (MF) on nanofluid passing through a cone and wedge with mass and heat transmission. Solving nonlinear partial differential equations (PDEs) that employ similarity transformations to transform into a collection of ordinary differential equations. The temperature equation considers physical aspects like elastic deformation, while the concentration equation considers external sources of local contaminants. Using numerical methods (Runge–Kutta–Fehlberg 4th 5th and shooting method), ordinary differential equations and related reduced boundary conditions (BCs) are solved. Plots are used to illustrate the significance of dimensionless constraints and their effects. The novel outcomes show that increases in elastic deformation constraint decrease the temperature distribution, and a rise in the local pollutant external source increases the concentration profile. The rate of mass and heat transfer, as well as fluid surface drag force, is enhanced by including solid volume fraction in combination with other parameters. The cone performs well in the rate of heat transfer and fluid surface drag force, while the wedge is in the rate of mass transmission. The study's outcomes are helpful in several practical applications, including enhanced cooling systems, environmental remediation, processing of materials, and nanotechnology.
Bothersome Pelvic Floor Dysfunction and Quality of Life During Pregnancy and Postpartum in Primiparous Women
Authors: Nestor Sofia , Brynhildsen Jan , Hiyoshi Ayako , Jansson Markus Harry 
Published: January 2025

Abstract

Introduction and Hypothesis
This is a prospective cohort study based on the hypothesis that pregnancy and childbirth are associated with the occurrence of bothersome pelvic floor dysfunction (PFD), which impairs health-related quality of life (HRQoL).

Methods
Primiparous women completed a questionnaire including questions about bothersome PFD and HRQoL in early pregnancy, late pregnancy, 8 weeks postpartum, and 12 months postpartum. HRQoL was measured using the Incontinence Impact Questionnaire, Short Form (IIQ-7). The association between bothersome urinary incontinence (UI) 1 year postpartum and maternal and delivery characteristics was examined using generalized linear models.

Results
The study sample comprised 851 women. The prevalence of bothersome UI increased from 0.7% in early pregnancy to 8.1% at 1 year postpartum. At 1 year postpartum, 22.8% of the women reported PFD with impairment in HRQoL, with a median IIQ-7 score of 14.3. Bothersome UI in late pregnancy (adjusted RR 4.51, 95% CI 1.43–14.26) and 8 weeks postpartum (adjusted RR 10.17, 95% CI 5.45–18.98) were associated with bothersome UI 1 year postpartum.

Conclusions
Most women were not bothered by UI during pregnancy and up to 1 year postpartum and did not report PFD with impairment in HRQoL. Most women who reported PFD with impairment in HRQoL had low IIQ-7 scores, but a few women reported substantial restriction in lifestyle. Bothersome UI in late pregnancy and 8 weeks postpartum was predictive of bothersome UI 1 year postpartum. This indicates the importance of the early identification of these women to provide appropriate counseling and treatment.
DNA mixture deconvolution using fully continuous models EuroForMix and EFMrep
Authors: Schiller Roberta , Fleckhaus Jan , von Máriássy Dagmar , Brune Verena , Bayer Birgit , Anslinger Katja 
Published: January 2025

Abstract

Background and objective
In the molecular genetic context, deconvolution describes the derivation of individual DNA profiles from a DNA mixture. Whereas mixture deconvolution is conventionally carried out manually by an expert, there are various probabilistic software applications to automate the process and two of these applications, EuroForMix (EFM) and EFMrep, are used in numerous forensic laboratories. They are particularly helpful when trace material is degraded or PCR artifacts are present and multiple replicates, if applicable from different DNA extracts, are combined for a better assessment. The aim of this study was to evaluate software-assisted deconvolution (EFM and EFMrep) with respect to correctly derived genotypes or alleles per profile in comparison to manual deconvolution based on a combination of at least two different DNA extracts per case.

Material and methods
To this end, 16 cases from former routine work were selected as examples and re-evaluated with EFM and EFMrep. In all cases, the manually derived profiles were incomplete due to the complexity of the underlying mixtures but still generated a hit in the German DNA Analysis Database (DAD). Likelihood calculations were performed for each match and the corresponding mixtures before the respective profiles were accepted as ground truth and the reference for deconvolution.

Results and conclusion
The results show that both forms of software are a useful addition to manual deconvolution, although they cannot replace it. Thus, when run in parallel they can objectively support the expert when there is uncertainty about an allele or genotype. In several cases it was shown that alleles were not correctly derived despite taking the threshold for the probability of results suggested in the current recommendations into account.
BMP6 participates in the molecular mechanisms involved in APAP hepatotoxicity
Authors: Marañón Patricia , Isaza Stephania C. , Rey Esther , Rada Patricia , García-García Yaiza , Dear James W. , García-Monzón Carmelo , Valverde Ángela M. , Egea Javier , González-Rodríguez Águeda 
Published: January 2025

Abstract
Given the lack of accurate diagnostic methods of acetaminophen (APAP)-induced acute liver failure (ALF), the search for new biomarkers for its diagnosis is an urgent need. The aim of this study was to evaluate the role of bone morphogenetic protein 6 (BMP6) in APAP-induced ALF progression and its potential value as a biomarker of ALF. Hepatic and circulating BMP6 expression was assessed in APAP-treated mice and in serum samples from patients with APAP overdose. In addition, BMP6 expression and release was evaluated in hepatocytes after APAP exposure. BMP6 gene was silenced in Huh7 cells prior to APAP treatment and the culture medium (CM) was added to THP1 cells to evaluate the paracrine effects of hepatocyte BMP6 on APAP toxicity. Hepatic and serum BMP6 levels were increased in mice after APAP-induced ALF. In addition, a positive correlation was observed between circulating BMP6 and ALT activity in patients exposed to APAP overdose. Moreover, hepatocytes expressed and released BMP6 to the CM after APAP treatment. Indeed, the CM from APAP-treated Huh7 cells upregulated M1 and M2 markers in THP1 monocytes. The CM from BMP6-silenced Huh7, which was depleted of BMP6, reduced the expression of M2 markers in THP1 cells. In fact, expression of M2 markers was increased in THP1 cells exposed to BMP6. This study reveals that hepatic BMP6 expression is increased in APAP-induced acute liver injury, positioning it as a potential new biomarker of liver damage severity. Moreover, our data indicate that BMP6 might play a role in the hepatocyte–macrophage crosstalk during APAP-induced hepatotoxicity.
Riemannian acceleration with preconditioning for symmetric eigenvalue problems
Authors: Shao Nian , Chen Wenbin 
Published: January 2025

Abstract
The analysis of the acceleration behavior of gradient-based eigensolvers with preconditioning presents a substantial theoretical challenge. In this work, we present a novel framework for preconditioning on Riemannian manifolds and introduce a metric, the leading angle, to evaluate preconditioners for symmetric eigenvalue problems. We extend the locally optimal Riemannian accelerated gradient method for Riemannian convex optimization to develop the Riemannian acceleration with preconditioning (RAP) for symmetric eigenvalue problems, thereby providing theoretical evidence to support its acceleration. Our analysis of the Schwarz preconditioner for elliptic eigenvalue problems demonstrates that RAP achieves a convergence rate of

$$1-C\kappa ^{-1/2}$$

1
-
C

κ

-
1
/
2

, which is an improvement over the preconditioned steepest descent method’s rate of

$$1-C\kappa ^{-1}$$

1
-
C

κ

-
1

. The exponent in

$$\kappa ^{-1/2}$$

κ

-
1
/
2

is sharp, and numerical experiments confirm our theoretical findings.
How I do it: Modified operation technique for MR Conditional OSIA 3: anterior based flap for covering the implant
Authors: Brill Ioana T. , Dazert Stefan 
Published: January 2025

Abstract

Background
The new OSIA3 is 1.5 T and 3 T MR-Conditional. Skin related issues are the most common complications. Performing MRI, the implant is exposed to magnetic torque forces, thus creating more tension over the incision lines.

Methods
We present a modified surgical technique for implanting OSI300 step-by-step. We prefer an anterior based muscle-periosteal flap to cover the implant as an integral part of the procedure.

Conclusion
The anterior based muscle-periosteal flap and performing a 3-layer-suture appears to be a safe method that does not permit skin-tension directly over the implant and may help preventing implant extrusion especially with the new OSI300.
Null-lagrangians in the micro-inertia contribution of the reduced relaxed micromorphic model. Theoretical and computational insights with applications
Authors: Erel-Demore Félix , Voss Jendrik , Neff Patrizio , Madeo Angela 
Published: January 2025

Abstract
This paper identifies a null-Lagrangian in the reduced relaxed micromorphic model. We show that the introduction of a micro-inertia depending on the skew-symmetric part of

$$\nabla \dot{u}$$

∇

u
˙

with the macroscopic displacement field u does not enrich the dispersion relations of the reduced relaxed micromorphic model. Reciprocally, we show that one can switch from the full micro-inertia (with both sym

$$\nabla \dot{u}$$

∇

u
˙

and skew

$$\nabla \dot{u}$$

∇

u
˙

terms) to the reduced micro-inertia (only sym

$$\nabla \dot{u}$$

∇

u
˙

) without any additional fitting. This is related to the fact that the introduction of such a skew-symmetric term is equivalent to a null-Lagrangian that leaves the bulk response unchanged while modifying the Neumann boundary conditions at the boundaries. Thus, the introduction of the skew-symmetric part of the micro-inertia, while redundant for wave dispersion, may potentially be used to improve the response of finite-size mechanical metamaterials at the homogenized macroscale due to boundary effects.
Retrospective analysis of criteria for oncological completion surgery of neuroendocrine tumors of the appendix
Authors: Wächter Sabine , Panidis Dimitrios , Jesinghaus Moritz , Rinke Anja , Heinzel-Gutenbrunner Monika , Maurer Elisabeth , Bartsch Detlef K. 
Published: January 2025

Abstract

Purpose
Neuroendocrine neoplasms of the appendix (aNET) are rare tumors that are often diagnosed by pathology as an incidental finding after appendectomy for acute appendicitis. Several guidelines proposed risk criteria to indicate oncological completion surgery after appendectomy. The aim of this study was to evaluate the reliability of proposed criteria for completion surgery of aNET.

Methods
Patients with aNET treated at ENETS center of excellence Marburg between 2002 and 2022 were retrieved from a prospective data base. Demographic data, histopathological findings, including formerly proposed criteria to indicate oncological completion surgery, histological results of the completion resection and disease-free survival were evaluated.

Results
82 patients with a median age of 35 (range 8–82) years were analysed. 72 (88%) patients underwent an emergency appendectomy because of acute appendicitis. 11 (13%) patients received an ileocecal resection or right hemicolectomy. Seven (8.5%) patients had lymph node metastases and three (3.6%) patients had distant metastases at the initial operation. 27 (33%) patients underwent completion surgery by right hemicolectomy according to guideline criteria, but postoperative histology detected lymph node and distant metastases in only six (22%) and zero patients resulting in an overtreatment of 21 (75%) patients. A tumor size of > 2 cm was the only significant criterion which was associated with lymph node metastases (p < 0.05). After a median follow-up of 62 months (range 2-264) 76 (96%) of the patients in stages I to III were alive with no evidence of disease.

Conclusion
aNET have an excellent prognosis in stages I-III and distant metastases are rare. Formerly proposed criteria for oncological completion surgery have to be adopted and discussed for every patient, as they might result in an overtreatment in at least 75% of patients.
Action toward sound sources enhances auditory spatial confidence: on the metacognitive consequences of reaching to sounds
Authors: Valzolgher Chiara , Lever Lisa , Rosi Tommaso , Pavani Francesco 
Published: January 2025

Abstract
Each perceptual process is accompanied with an evaluation regarding the reliability of what we are perceiving. The close connection between confidence in perceptual judgments and planning of actions has been documented in studies investigating visual perception. Here, we extend this investigation to auditory perception by focusing on spatial hearing, in which the interpretation of auditory cues can often present uncertainties. We asked if confidence in perceived sound position changes when we interact with the sound source by planning a sound-directed motor action (reaching) vs. a verbal response (naming). We tested 30 participants in a sound localization task in which they were both asked to localize sound sources by reaching them or by naming the labels above them in a within-participants experimental design. Participants performed the task with binaural hearing and with one ear plugged to increase errors and reduce confidence. Results showed that sound localization performance did not differ between reaching and naming, and yet participants felt more confident and required less time to complete the trial when reaching to the sources compared to naming them, regardless of the listening condition. Moreover, we found that during monaural listening the coherence between performance and confidence was reduced in each trial, irrespective of response type, suggesting increased difficulties in metacognitive monitoring. These findings suggest that, even in the case of spatial hearing, motor action planning plays a role in the formulation of confidence judgments, alongside sensory inputs and decision-making processes and stress the importance of including metacognitive measurements into spatial hearing research.
Performance evaluation of the LIOFeron®TB/LTBI IGRA for screening of paediatric LTBI and tuberculosis
Authors: Della Bella Chiara , Motisi Marco Antonio , Venturini Elisabetta , D’Elios Sofia , Asvestopoulou Evangelia , Tamborino Agnese Maria , Galli Luisa , D’Elios Mario Milco , Chiappini Elena 
Published: January 2025

Abstract
Purpose: High-accuracy diagnostic screening tests for Mycobacterium tuberculosis (MTB) infection are required, primarily to detect patients with latent infections (LTBIs) in order to avoid their progression to active tuberculosis disease. The performance of the novel IGRA LIOFeron®TB/LTBI was evaluated in children. The originality of this test is the new MTB antigen contained (l-alanine dehydrogenase), identified as a tool to differentiate active TB from LTBI infection. Methods: From March 2022 to November 2023, a population of 90 children was enrolled and grouped into healthy, active TB or LTBI individuals, based on diagnostic guidelines. The blood of all these participants was tested with LIOFeron®TB/LTBI assay in comparison to diagnosis, as gold standard, and to the current used IGRA QuantiFERON®-TB Gold Plus. Results: The two assays demonstrated an excellent concordance of their results with patients’ diagnosis of MTB infection. The performance of LIOFeron®TB/LTBI assay in terms of accuracy of MTB infection diagnosis was high at ROC analysis (AUC = 0.997), and the test showed 100% sensitivity in LTBI detection. The QuantiFERON®-TB Gold Plus sensitivity for LTBI detection was 85.7%.

Conclusions: Based on the obtained results, the LIOFeron®TB/LTBI assay appears to be a promising test for TB and LTBI screening among paediatric patients.

What is known:• The detection of LTBI in children, exposed to MTB infections, followed by appropriate treatment, has a pivotal role in reducing tuberculosis burden.
• IGRA tests are easy-to-use methods for helping large TB screening in paediatrics.

What is new:• The LIOFeron®TB/LTBI performance evaluation showed 100% of sensitivity in the detection of LTBI patients.
• The LIOFeron®TB/LTBI assay might be useful for the detection of LTBI and active tuberculosis paediatric patients.
Design-based mapping of errors in remote sensing-based land use/land cover maps
Authors: Di Biase R. M. , Marcelli A. , Corona P. , Stehman S. V. , Fattorini L. 
Published: January 2025

Abstract
For the first time, spatially explicit representation of classification errors of land use/land cover (LULC) maps is approached from a design-based perspective. Since LULC maps are typically derived from non-probabilistic training samples, these maps, like the true LULC map, are fixed in a design-based scenario so that the error maps achieved by comparing the satellite-based and true maps are fixed. Based on a probabilistic sample of locations where the true or “reference” class is obtained (i.e., the “reference” class is considered the best representation of the true class), errors can be assessed at these sample locations by comparing the map classes to the reference classes. Then, the presence or absence of errors is interpolated across the entire survey area using the nearest neighbour technique. Under very common sampling schemes used to collect reference sample data, the interpolated error maps are design consistent. A simulation study confirms the design consistency of the interpolated error maps, which converge to the true error map as the reference sample size increases. The U.S. land cover map from the LCMAP program and the Italian forest/non forest map serve as case studies.
Predictive value of enhanced corneal biomechanical parameters for ectasia progression
Authors: Koh Shizuka , Ambrósio Renato , Inoue Ryota , Belin Michael W. , Maeda Naoyuki , Nishida Kohji 
Published: January 2025

Abstract

Purpose
To determine whether corneal biomechanical parameters can predict ectasia progression.

Study design
Retrospective observational study.

Methods
The baseline corneal biomechanical parameters of 64 eyes of 41 young patients (age, < 25 years at the first visit) who were diagnosed with keratoconus (KC) or suspected KC at Osaka University Hospital and followed up for more than two years were reviewed. Suspected KC was defined as borderline cases with no definitive clinical or topographical abnormalities in both eyes. The eyes were divided into progressed (P) and non-progressed (NP) groups using the ABCD grading system of Scheimpflug-based tomography. The Scheimpflug-based corneal biomechanical parameters evaluated included deformation amplitude ratio within 2 mm, integrated radius, Ambrósio relational thickness to the horizontal profile, stiffness parameter at the first applanation, stress–strain index, E-staging, and Corvis Biomechanical Index. The optimized tomographic/biomechanical index (TBIv2), Belin/Ambrósio Enhanced Ectasia Deviation (BAD-D), and inferior-superior axial steepening values from Scheimpflug-based tomography were also evaluated.

Results
Twenty-three and 41 eyes were categorized into the P and NP groups, respectively. Logistic regression analysis showed that age, BAD-D, and TBIv2 could predict ectasia progression. The specificity, sensitivity, and area under the receiver operating characteristic curve (AUROC) values for BAD-D combined with age were 0.82, 0.60, and 0.83, respectively, whereas those for TBIv2 combined with age were 0.65, 0.82, and 0.82, respectively.

Conclusions
Baseline TBIv2 is a potentially useful predictive marker for ectasia progression in young patients, whereas baseline BAD-D could be used for establishing a definitive diagnosis.
Navigating life’s twists and turns: characteristics of life events across adulthood
Authors: Radjenovic Sonja , Rupprecht Fiona S. , Nikitin Jana 
Published: January 2025

Abstract
This study examines whether there are age-related differences in the experience of life events across adulthood. We hypothesized that older adults would report life events that are less anticipated, less normative, less controllable, less positive, and more strenuous than younger adults due to increasing developmental losses and decreasing gains. We investigated how age (linear, quadratic, and cubic) relates to life-event characteristics by comparing different events and analyzing the same events across individuals, to distinguish between the effects observed across life events and those that emerge after accounting for the specific life event in question. Additionally, we hypothesized that older adults would cope better with less favorable events due to their life experience and emotion regulation skills. Analyses of 6,688 participants (18–90 years) showed that while older adults reported less favorable life events, they coped better with the same events than younger adults. The results underscore the importance of distinguishing between age and life event effects. They also show that life-event characteristics are consistently linked to well-being throughout adulthood.