bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the representation of heatwaves from an ensemble of km-scale regional climate simulations within CORDEX-FPS convection
Authors: Sangelantoni L. , Sobolowski S. , Lorenz T. , Hodnebrog Ø. , Cardoso R. M. , Soares P. M. M. , Ferretti R. , Lavín-Gullón A. , Fernandez J. , Goergen K. , Milovac J. , Katragkou E. , Kartsios S. , Coppola E. , Pichelli E. , Adinolfi M. , Mercogliano P. , Berthou S. , de Vries H. , Dobler A. , Belušić D. , Feldmann H. , Tölle M. H. , Bastin S. 
Published: April 2023

AbstractHeatwaves (HWs) are high-impact phenomena stressing both societies and ecosystems. Their intensity and frequency are expected to increase in a warmer climate over many regions of the world. While these impacts can be wide-ranging, they are potentially influenced by local to regional features such as topography, land cover, and urbanization. Here, we leverage recent advances in the very high-resolution modelling required to elucidate the impacts of heatwaves at these fine scales. Further, we aim to understand how the new generation of km-scale regional climate models (RCMs) modulates the representation of heatwaves over a well-known climate change hot spot. We analyze an ensemble of 15 convection-permitting regional climate model (CPRCM, ~ 2–4 km grid spacing) simulations and their driving, convection-parameterized regional climate model (RCM, ~ 12–15 km grid spacing) simulations from the CORDEX Flagship Pilot Study on Convection. The focus is on the evaluation experiments (2000–2009) and three subdomains with a range of climatic characteristics. During HWs, and generally in the summer season, CPRCMs exhibit warmer and drier conditions than their driving RCMs. Higher maximum temperatures arise due to an altered heat flux partitioning, with daily peaks up to ~ 150 W/m2 larger latent heat in RCMs compared to the CPRCMs. This is driven by a 5–25% lower soil moisture content in the CPRCMs, which is in turn related to longer dry spell length (up to double). It is challenging to ascertain whether these differences represent an improvement. However, a point-scale distribution-based maximum temperature evaluation, suggests that this CPRCMs warmer/drier tendency is likely more realistic compared to the RCMs, with ~ 70% of reference sites indicating an added value compared to the driving RCMs, increasing to 95% when only the distribution right tail is considered. Conversely, a CPRCMs slight detrimental effect is found according to the upscaled grid-to-grid approach over flat areas. Certainly, CPRCMs enhance dry conditions, with knock-on implications for summer season temperature overestimation. Whether this improved physical representation of HWs also has implications for future changes is under investigation.
Executive functioning of patients with congenital heart disease: 45 years after surgery
Authors: Pelosi C. , Kauling R. M. , Cuypers J. A. A. E. , Utens E. M. W. J. , van den Bosch A. E. , Kardys I. , Bogers A. J. J. C. , Helbing W. A. , Roos-Hesselink J. W. , Legerstee Jeroen S. 
Published: April 2023

Abstract
Background
Nowadays, more than 90% of patients with congenital heart disease (CHD) reach adulthood. However, long-term impact on neurodevelopment and executive functioning in adults with CHD are not completely understood.

Purpose
To investigate the self- and informant-reported executive functioning in adults with CHD operated in childhood.

Material and methods
Longitudinal study of a cohort of patients (n = 194, median age: 49.9 [46.1–53.8]) who were operated in childhood (< 15 years old) between 1968 and 1980 (median follow-up time: 45 [40–53] years) for one of the following diagnoses: atrial septal defect (ASD), ventricular septal defect (VSD), pulmonary stenosis (PS), tetralogy of Fallot (ToF) or transposition of the great arteries (TGA). Behavior Rating Inventory of Executive Function-Adult version (BRIEF-A) questionnaire was used to assess self- and informant-reported executive functioning.

Results
40–53 years after surgery, the CHD group did show significantly better executive functioning compared to the norm data. No significant difference was found between mild CHD (ASD, VSD and PS) and moderate/severe CHD (ToF and TGA). Higher education, NYHA class 1 and better exercise capacity were associated with better self-reported executive functioning, whereas females or patients taking psychiatric or cardiac medications reported worse executive functioning.

Conclusions
Our findings suggest favorable outcomes (comparable to normative data) regarding executive functioning in adults with CHD, both self- and informant-reported. However, further study is warranted to explore more in detail the different cognitive domains of executive functioning in these patients.

Graphical abstract
Plasma p-tau181 and p-tau217 in discriminating PART, AD and other key neuropathologies in older adults
Authors: Yu Lei , Boyle Patricia A. , Janelidze Shorena , Petyuk Vladislav A. , Wang Tianhao , Bennett David A. , Hansson Oskar , Schneider Julie A. 
Published: April 2023

AbstractWe examined whether plasma p-tau181 and p-tau217 are specific biomarkers of pathologically confirmed Alzheimer’s disease (AD). In particular, we investigated the utility of plasma p-tau for differentiating AD from primary age-related tauopathy (PART), as well as AD with mixed pathologies. Data came from 269 older adults who participated in the Religious Orders Study or the Rush Memory and Aging Project. Blood samples were collected during annual clinical evaluations. Participants died and underwent brain autopsy. P-tau181 and p-tau217 were quantified in the plasma samples proximate to death (average interval before death: 1.4 years) using Lilly-developed MSD immunoassays. Uniform neuropathologic evaluations assessed AD, PART, and other common degenerative and cerebrovascular conditions. Plasma p-tau217 was more strongly correlated with brain β-amyloid and paired helical filament tau (PHFtau) tangles than p-tau181. Both p-tau markers were associated with greater odds of AD, but p-tau217 had higher accuracy (area under the ROC curve (AUC): 0.83) than p-tau181 (AUC: 0.76). Plasma p-tau markers were almost exclusively associated with AD pathologic indices with the exception of cerebral amyloid angiopathy. Compared to p-tau181, p-tau217 showed a higher AUC (0.82 versus 0.74) in differentiating AD from PART. For either p-tau, we did not observe a level difference between individuals with AD alone and those with mixed AD pathologies. In summary, plasma p-tau181and p-tau217 were specifically associated with AD pathological changes. Further, our data provide initial evidence that p-tau217 may be able to differentiate between AD and PART in individuals with comparable burdens of tau tangle pathology. These results demonstrate the specificity of p-tau217 for AD, supporting its use to identify patients suitable for anti-AD therapies including β-amyloid immunotherapies.
Oncolytic adenoviruses and the treatment of pancreatic cancer: a review of clinical trials
Authors: Taylor Isobel P. , Lopez J. Alejandro 
Published: April 2023

Abstract
Purpose
Pancreatic ductal adenocarcinoma (PDAC) remains a common and difficult cancer to treat. Surgical resection and chemotherapy are standard of care and clinical outcomes remain poor. Oncolytic adenoviruses are a unique approach to the treatment of this challenging cancer, aiming to overcome the features of this disease that pose the key obstacles to standard therapies. This paper provides a detailed review of the clinical trials of conditionally-replicative adenoviruses in pancreatic cancer to date, with a brief summary of the past preclinical literature and future prospects of this therapy.

Methods
MEDLINE, Embase, and clinicaltrials.gov were searched from inception to December 23rd 2022 for clinical trials of conditionally-replicative adenoviruses used in patients with pancreatic ductal adenocarcinoma. Primary features for review included patient demographics, treatment protocol including dose and administration route, adverse events, patient responses and survival rates.

Results
The six published clinical trials suggest that objective clinical responses can be achieved with a tolerable level of side effects, even at high viral doses. The more clinically adaptable intravenous route of administration also appears to be as well tolerated as the more challenging intratumoural injections.

Conclusion
Published clinical trials provide data of the safety and some signs of oncolytic activity of conditionally-replicative adenoviruses in patients with pancreatic cancer. Importantly, on the latest trials, the easier intravenous route of administration seems to be well tolerated and safe, providing the opportunity for further clinical evaluation. It is hoped that the ongoing clinical trials will yield more promising results of this therapeutic approach against a currently intractable disease.
Cancer immune escape: the role of antigen presentation machinery
Authors: Kallingal Anoop , Olszewski Mateusz , Maciejewska Natalia , Brankiewicz Wioletta , Baginski Maciej 
Published: April 2023

AbstractThe mechanisms of antigen processing and presentation play a crucial role in the recognition and targeting of cancer cells by the immune system. Cancer cells can evade the immune system by downregulating or losing the expression of the proteins recognized by the immune cells as antigens, creating an immunosuppressive microenvironment, and altering their ability to process and present antigens. This review focuses on the mechanisms of cancer immune evasion with a specific emphasis on the role of antigen presentation machinery. The study of the immunopeptidome, or peptidomics, has provided insights into the mechanisms of cancer immune evasion and has potential applications in cancer diagnosis and treatment. Additionally, manipulating the epigenetic landscape of cancer cells plays a critical role in suppressing the immune response against cancer. Targeting these mechanisms through the use of HDACis, DNMTis, and combination therapies has the potential to improve the efficacy of cancer immunotherapy. However, further research is needed to fully understand the mechanisms of action and optimal use of these therapies in the clinical setting.
Cross-chain payment protocols with success guarantees
Authors: van Glabbeek Rob , Gramoli Vincent , Tholoniat Pierre 
Published: April 2023

AbstractIn this paper, we consider the problem of cross-chain payment whereby customers of different escrows—implemented by a bank or a blockchain smart contract—successfully transfer digital assets without trusting each other. Prior to this work, cross-chain payment problems did not require this success, or any form of progress. We introduce a new specification formalism called Asynchronous Networks of Timed Automata to formalise such protocols. We present the first cross-chain payment protocol that ensures termination in a bounded amount of time and works correctly in the presence of clock drift. We then demonstrate that it is impossible to solve this problem without assuming synchrony, in the sense that each message is guaranteed to arrive within a known amount of time. Yet, we solve an eventually terminating weaker variant of this problem, where success is conditional on the patience of the participants, without assuming synchrony, and in the presence of Byzantine failures. We also discuss the relation with the recently defined cross-chain deals.
Health professionals’ perspective on the applicability of AO Spine PROST (patient reported outcome Spine trauma) in people with a motor-complete traumatic or non-traumatic spinal cord injury
Authors: Hakbijl - van der Wind Aline J. , Post Marcel W. M. , van Diemen Tijn , Schnake Klaus J. , Benneker Lorin M. , Kandziora Frank , Rajasekaran Shanmuganathan , Schroeder Gregory D. , Vaccaro Alexander R. , Öner F. Cumhur , Sadiqi Said 
Published: April 2023

Abstract
Purpose
The AO Spine PROST (Patient Reported Outcome Spine Trauma) was developed for people with spine trauma and minor or no neurological impairment. The purpose is to investigate health professionals’ perspective on the applicability of the AO Spine PROST for people with motor-complete traumatic or non-traumatic spinal cord injury (SCI), using a discussion meeting and international survey study.

Methods
A discussion meeting with SCI rehabilitation physicians in the Netherlands was performed, followed by a worldwide online survey among the AO Spine International community, involved in the care of people with SCI. Participants rated the comprehensibility, relevance, acceptability, feasibility and completeness of the AO Spine PROST on a 1–5 point scale (5 most positive). Comments could be provided per question.

Results
The discussion meeting was attended by 13 SCI rehabilitation physicians. The survey was completed by 196 participants. Comprehensibility (mean ± SD: 4.1 ± 0.8), acceptability (4.0 ± 0.8), relevance (3.9 ± 0.8), completeness (3.9 ± 0.8), and feasibility (4.1 ± 0.7) of the AO Spine PROST were rated positively for use in people with motor-complete traumatic or non-traumatic SCI. Only a few participants questioned the relevance of items on the lower extremities (e.g., walking) or missed items on pulmonary functioning and complications. Some recommendations were made for improvement in instructions, terminology and examples of the tool.

Conclusion
Health professionals found the AO Spine PROST generally applicable for people with motor-complete traumatic or non-traumatic SCI. This study provides further evidence for the use of the AO Spine PROST in spine trauma care, rehabilitation and research, as well as suggestions for its further development.
Deep spatial and tonal data optimisation for homogeneous diffusion inpainting
Authors: Peter Pascal , Schrader Karl , Alt Tobias , Weickert Joachim 
Published: April 2023

AbstractDiffusion-based inpainting can reconstruct missing image areas with high quality from sparse data, provided that their location and their values are well optimised. This is particularly useful for applications such as image compression, where the original image is known. Selecting the known data constitutes a challenging optimisation problem, that has so far been only investigated with model-based approaches. So far, these methods require a choice between either high quality or high speed since qualitatively convincing algorithms rely on many time-consuming inpaintings. We propose the first neural network architecture that allows fast optimisation of pixel positions and pixel values for homogeneous diffusion inpainting. During training, we combine two optimisation networks with a neural network-based surrogate solver for diffusion inpainting. This novel concept allows us to perform backpropagation based on inpainting results that approximate the solution of the inpainting equation. Without the need for a single inpainting during test time, our deep optimisation accelerates data selection by more than four orders of magnitude compared to common model-based approaches. This provides real-time performance with high quality results.
Hyperbolicity cones are amenable
Authors: Lourenço Bruno F. , Roshchina Vera , Saunderson James 
Published: April 2023

AbstractAmenability is a notion of facial exposedness for convex cones that is stronger than being facially dual complete (or ‘nice’) which is, in turn, stronger than merely being facially exposed. Hyperbolicity cones are a family of algebraically structured closed convex cones that contain all spectrahedral cones (linear sections of positive semidefinite cones) as special cases. It is known that all spectrahedral cones are amenable. We establish that all hyperbolicity cones are amenable. As part of the argument, we show that any face of a hyperbolicity cone is a hyperbolicity cone. As a corollary, we show that the intersection of two hyperbolicity cones, not necessarily sharing a common relative interior point, is a hyperbolicity cone.
Myocardial Biomechanics and the Consequent Differentially Expressed Genes of the Left Atrial Ligation Chick Embryonic Model of Hypoplastic Left Heart Syndrome
Authors: Lashkarinia S. Samaneh , Chan Wei Xuan , Motakis Efthymios , Ho Sheldon , Siddiqui Hummaira Banu , Coban Mervenur , Sevgin Bortecine , Pekkan Kerem , Yap Choon Hwai 
Published: April 2023

AbstractLeft atrial ligation (LAL) of the chick embryonic heart is a model of the hypoplastic left heart syndrome (HLHS) where a purely mechanical intervention without genetic or pharmacological manipulation is employed to initiate cardiac malformation. It is thus a key model for understanding the biomechanical origins of HLHS. However, its myocardial mechanics and subsequent gene expressions are not well-understood. We performed finite element (FE) modeling and single-cell RNA sequencing to address this. 4D high-frequency ultrasound imaging of chick embryonic hearts at HH25 (ED 4.5) were obtained for both LAL and control. Motion tracking was performed to quantify strains. Image-based FE modeling was conducted, using the direction of the smallest strain eigenvector as the orientations of contractions, the Guccione active tension model and a Fung-type transversely isotropic passive stiffness model that was determined via micro-pipette aspiration. Single-cell RNA sequencing of left ventricle (LV) heart tissues was performed for normal and LAL embryos at HH30 (ED 6.5) and differentially expressed genes (DEG) were identified.After LAL, LV thickness increased by 33%, strains in the myofiber direction increased by 42%, while stresses in the myofiber direction decreased by 50%. These were likely related to the reduction in ventricular preload and underloading of the LV due to LAL. RNA-seq data revealed potentially related DEG in myocytes, including mechano-sensing genes (Cadherins, NOTCH1, etc.), myosin contractility genes (MLCK, MLCP, etc.), calcium signaling genes (PI3K, PMCA, etc.), and genes related to fibrosis and fibroelastosis (TGF-β, BMP, etc.). We elucidated the changes to the myocardial biomechanics brought by LAL and the corresponding changes to myocyte gene expressions. These data may be useful in identifying the mechanobiological pathways of HLHS.
In a nutshell: exploring single tree parameters and above-ground carbon sequestration potential of common walnut (Juglans regia L.) in agroforestry systems
Authors: Schindler Zoe , Morhart Christopher , Sheppard Jonathan P. , Frey Julian , Seifert Thomas 
Published: April 2023

AbstractAlthough agroforestry systems (AFS) provide numerous ecosystem services and are a recognized strategy for climate change mitigation and adaptation, knowledge on the woody component is lacking. Single tree data could improve planning, management and optimization of AFS. One tree species which is of great interest due to its valuable timber and non-timber products is walnut (Juglans regia L.). We used terrestrial laser scanning data to fit quantitative structure models (QSMs) for 65 walnut trees in AFS with diameter at breast height (DBH) ranging from 1 to 77 cm. Based on the QSMs, volumetric information as well as height and crown parameters were derived. By combining the volumetric data with bark and wood density followed by carbon and nutrient concentration, whole tree biomass, nutrient and carbon content were derived. To enable the application of our results, we modeled allometric relationships based on the DBH. The maximum crown projection area of a tree was more than 340 m2, the maximum leafless above-ground dry biomass was 7.4 t and the maximum amount of stored carbon was 3.6 t (in metric tons). A modelled AFS comprising 15 trees per hectare with a target DBH of 60 cm projects at the end of its 60-year rotation period an above-ground tree volume of more than 100 m3, about 60 t of dry biomass and roughly 30 t of sequestered carbon. By producing allometric functions, we provide much needed information for small-scale modelling of AFS.
The 3D Method: A Tool to Analyze Positions in Animal and Environmental Ethics
Authors: Camenzind Samuel 
Published: April 2023

AbstractOver the past fifty years numerous ethical and political traditions, and positions and sub-positions, have emerged in the fields of animal and environmental ethics. In combination with inconsistent terminology and axiological variation, this has made it difficult for both novices and professional scholars to maintain an overview of these fields. Referring to the preliminary work of Kenneth Goodpaster, William Frankena and Kirsten Schmidt, this paper describes and explains a workable 3D method in which advantageous use is made of three dimensions in ethical argumentation: “moral considerability”, “moral significance” and “moral practice”. The method is a useful research tool for at least three reasons: it allows us to systematically analyze, reconstruct, compare and criticize different normative positions in animal and environmental ethics; it helps ethical theorists to reflect on, and define, their distinctive positions; and it leads to the construction and development of a moral position with the desirable qualities of clarity, transparency, comprehensibility and completeness. First, the 3D method is introduced, and its historical context and origins outlined. Then the three dimensions of the method (moral considerability, moral significance, and moral practice) and their interrelations are considered. The paper concludes with some critical remarks and discusses the limits of the method.
Zirconia-based coatings for the protection of ferritic-martensitic steels in a molten salt environment for CSP technology
Authors: Encinas-Sánchez Víctor , Macías-García Antonio , García-Martín Gustavo , Pérez Trujillo Francisco Javier , Rodríguez-Rego Jesús Manuel 
Published: April 2023

AbstractThe ferritic-martensitic 9Cr-1Mo steel was coated with a sol-gel ZrO2-3%molY2O3 solution by dip-coating. The protective properties of the coating were evaluated in contact with Solar Salt for CSP applications. The coated and uncoated steels were tested at 500 °C in contact with the Solar Salt for 2000 h. Gravimetric, microstructural and compositional studies were performed to compare their behaviour, against corrosion. Results revealed the beneficial influence of the coating on the corrosion resistance of P91 in contact with molten nitrate salt. Weight gain of the coated samples remained practically unaltered throughout the test, while the uncoated samples showed a weight increase with the formation of multi-layered, non-adherent corrosion layers that were spalled during the test. The microstructural and compositional study performed on the samples shows the maintenance of the coating layer and the presence of a 5.18 μm-thick diffusion layer primarily composed of Fe-Zr species, which reduce the ionic diffusion and improve the protective properties. Results reveal the possible suitability of the proposed system as a potential solution to the severe corrosion problems industrial tanks and pipes in contact with Solar Salt.
Graphical Abstract