bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of hydrological regime alteration and ecological effects in the upper reaches of the Yangtze River, China
Authors: Jiao Hongbo , Guo Wenxian , Jiao Xuyang 
Published: April 2023

Abstract
The state of water flow is recognized as a key driver of the structure and function of river ecosystems. We selected streamflow data (1960–2020) from three key hydrological stations in the upper Yangtze River: Pingshan, Cuntan, and Yichang. We analyzed the characteristics and changes of the hydrologic regimes of the Yangtze River using the Mann–Kendall method, wavelet analysis, and the IHA-RVA method, and explored the response mechanisms of fish to changes in the hydrological regimes. The results show that (1) the average annual discharge of the upper reaches of the Yangtze River is decreasing, and the abrupt changes in Pingshan, Cuntan, and Yichang stations occurred in 1985, 1998, and 2002, respectively, with the main period of 24–32 years. (2) The overall degree of hydrological changes at Pingshan, Cuntan, and Yichang stations is 45%, 50%, and 61%, respectively, all of which are moderate changes. (3) Dams in the upper reaches of the Yangtze River have caused changes in the flow regime of the Yangtze River. Among them, the changes in the alternating frequency of flow and the annual extreme flow have affected the habitat of aquatic organisms and seriously affected the reproduction of important fishes in the Yangtze River.
Диагностические возможности анализа сновидений: теоретические предпосылки и методические подходы
Authors: Березина Зинаида И. , Кит Олег И. , Комарова Екатерина Ф. , Арапова Юлия Ю. , Протасова Татьяна П. 
Published: April 2023

Введение. Нарушение некоторых когнитивных функций и общего психического состояния после массированного лечения затрудняет использование при реабилитации общепринятых опросных методов для диагностики неврологического и психологического статуса. В этой связи актуальным методом представляется анализ сновидений, который, согласно современным исследованиям, позволяет выявить на ранних этапах нарушения психологического и соматического состояния пациентов и сделать прогноз об их восстановлении. Теоретическое обоснование. В основе возможности применения анализа сновидения в качестве диагностического метода лежат современные представления о нейрофизиологических и психических механизмах сновидческой активности. Изменения сновидческой активности отмечены разными авторами при неврологических, психических и соматических заболеваниях. Все больше исследователей сходятся во мнении, что сновидения могут быть предвестниками, своеобразной «сигнальной системой» формирующихся соматических, неврологических и психических нарушений. Клинико-диагностический анализ сновидений при невротических нарушениях позволил выявить их особенности как при разных вариантах неврозов, так и на всех стадиях заболевания – от компенсации до декомпенсации. Установлено существование взаимосвязи между образами сновидений и предрасположенностью к тревожным состояниям, депрессии и астении. Обсуждение результатов. Существующие научные исследования позволяют говорить о возможности применения анализа сновидений в качестве ранней диагностики невротических состояний и соматических патологий, клинические симптомы которых еще не проявились симптоматически, но уже появляются в сновидениях. В статье выполнен обзор литературы по современным представлениям о нейрофизиологических и психических механизмах сновидений, указаны возможности применения результатов их анализа в качестве диагностической модели.
Second-line Endocrine Therapy of Hormone Receptor-positive/HER2-
negative Advanced Breast Cancer: A Systematic Review and Network
Meta-analysis
Authors: Wang Tianzhuo , Shen Guoshuang , Li Jinming , Huo Xingfa , Wang Miaozhou , Liu Zhen , Zhao Fuxing , Ren Dengfeng , Zhao Jiuda 
Published: April 2023

Background:
The optimal second-line therapy for hormone receptor-positive (HR+)/ human
epidermal growth factor receptor 2 negative (HER2−) advanced or metastatic breast cancer is yet to be
established. Therefore, we conducted a network meta-analysis (NMA) of marketed drugs to compare
their efficacy.

Methods:
We searched the literature in PubMed, Embase, Web of Science databases, and the main
international conferences in the past 5 years to find phase III clinical trials on drugs available in the
market. Network meta-analysis of progression-free survival (PFS), overall survival (OS), and the objective
response rate (ORR) was performed using R software. The efficiency of treatment options was
compared using hazard ratios and 95% credibility intervals.

Results:
Overall, 12 studies with 6120 patients were included in the analysis. In an indirect comparison
of the five regimens, cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) plus 500 mg fulvestrant
(Ful500) gave the best PFS results; palbociclib ranked first with a surface under the cumulative ranking
(SUCRA) of 94.99%, followed by mammalian target of rapamycin inhibitor (mTORi) plus everolimus
(SUCRA=73.07%), phosphoinositide 3-kinase inhibitor (PI3Ki) plus Ful500 (SUCRA=66.73%),
Ful500 alone (SUCRA=44.55%), and histone deacetylase inhibitor (HDACi) plus exemestane (SUCRA=
43.49%). However, no significant difference was found in the PFS rates of CDK4/6i, mTORi,
and PI3Ki. For OS, CDK4/6i plus Ful500 ranked first; the SUCRA of ribociclib, abemaciclib, and palbociclib
were 86.20%, 83.98%, and 78.52%, respectively. Alpelisib plus Ful500 (SUCRA=66.91%)
ranked second but was not statistically different from CDK4/6i. The mTORi plus everolimus group
had the best ORR (SUCRA=88.73%). In terms of safety, 81.56% of patients in the tucidinostat plus
exemestane regimen developed neutropenia, suggesting strong hematological toxicity; 13.40% of patients
developed grade 3-4 diarrhea after using abemaciclib plus Ful500.

Conclusion:
For second-line endocrine therapy in HR+/HER2− advanced/metastatic breast cancer,
CDK4/6i is a better choice than mTORi, PI3Ki, HDACi, and Ful; it shows good PFS and OS outcomes
and a low probability for serious adverse events.
Electronic and Optical Properties of Na, Mg, and Al Substituted Zinc-oxide Nanotube: An Insight DFT Study
Authors: Howari Haidar , Khan Ziaul Raza , Imran Mohd , Shakir Mohd. , Khan Md. Shahzad 
Published: April 2023

Background:
The present work deals with DFT-based theoretical investigations on
pristine and metal (M = Na, Mg, and Al) substituted zinc oxide nanotube (M-ZnONT). The investigation
advocates a change in the electronic bandgap of ZnONT on the respective substitution of
Zn with Na, Mg, and Al. The forbidden energy gap vanishes on Na incorporation, while Al substitution
brings the gap to 0.08eV. The formation energy calculations suggest the feasibility of
these metallic substitutions, of which Na incorporation is most favorable. Partial density of state
(PDOS) analysis is well correlated with band structures. A localized state above the Fermi level
contributed from Al-3p in Al-ZnONT suggests the electronic affinity of Al-ZnONT for incoming
nucleophiles. Our optical investigation shows large ε1(ω) values in far-infrared (IR) and visible
(Vis) regions for M-ZnONT. Hence, suggests a high refractive index for the metal-substituted
ZnONTs in the prescribed range. The study suggests that photonic energy loss due to attenuation,
bending, and absorption are weak in ultra-violet (UV) and far UV regions i.e, (3eV to 8eV).
However, for the respective energy range, high reflectivity is predicted. This indicates the nanotubes
as a good reflector for the purpose of coating material surfaces where high reflection is demanded.

Objective:
Finding electronic and optical properties of functionalized ZnONT using DFT method.

Methods:
All calculations have been performed in the framework of density functional theory
(DFT) using Troullier Martins’s norm-conserving pseudo-potential.

Results:
Metal incorporation at the surface of ZnONT consequent intense ε1(ω) values in far infra-
red and visible regions for M-ZnONT.

Conclusion:
The investigation suggests that the metal-substituted nanotube is a good reflector for
coating material surfaces where high reflection is demanded.
Quality by Design Enabled β-Cyclodextrin Complexes of Lisinopril by
Kneading Method: Improved Solubility and Bioavailability
Authors: Mohammad Azeez , Singh Sumer , Swain Suryakanta , Ghose Debashish 
Published: April 2023

Background:
The primary intent of the study is to formulate the inclusion complex of
lisinopril with the varied compositions of polymers like β-cyclodextrin for the enhancement of
oral drug solubility and bioavailability using QbD approach.

Methods:
The application of Box-behnken design to determine the optimized run from the prepared
inclusion complexes. The physical kneading technique with β-cyclodextrin at varied
amounts was used to create the inclusion complex of lisinopril.

Results:
The FT-IR analysis study confirmed the selected drug, polymers, and other excipients
showed no physical interactions. The prepared inclusion complexes' particle sizes and encapsulation
efficiency were between 802 to 3259μm, 19.22 to 93.28%. The optimized formulation batch
(F5) showed 90.16% in vitro drug release at 24h compared to the pure drug. From the in vivo
study, the pharmacokinetic parameters for the optimized formulation (F5) were found to be Cmax
of 94.336 ng/ml, Tmax of 12h, and AUC 94.336 ng.h/ml, Kel of 0.0395h-1 and t1/2 of 12h. After
three months, stability studies for the optimized formulation batch indicate no change in drug entrapment
efficiency and other parameters.

Conclusion:
The β-cyclodextrin inclusion complex of lisinopril exhibited a 2-fold increase in the
oral bioavailability of the model drug, which will be the novel drug-delivery strategy for the
treatment of hypertension.
The Association Between Mobile App Use and Change in Functional Capacity Among Cardiac Rehabilitation Participants: Cohort Study
Authors: Oclaman Janah May , Murray Michelle L , Grandis Donald J , Beatty Alexis L 
Published: April 2023

Background
Cardiac rehabilitation (CR) is underused in the United States and globally, with participation disparities across gender, socioeconomic status, race, and ethnicities. The pandemic led to greater adoption of telehealth CR and mobile app use.

Objective
Our primary objective was to estimate the association between CR mobile app use and change in functional capacity from enrollment to completion in patients participating in a CR program that offered in-person, hybrid, and telehealth CR. Our secondary objectives were to study the association between mobile app use and changes in blood pressure (BP) or program completion.

Methods
We conducted a retrospective cohort study of participants enrolled in CR at an urban CR program in the United States. Participants were English speaking, at least 18 years of age, participated in the program between May 22, 2020, and May 21, 2022, and downloaded the CR mobile app. Mobile app use was quantified by number of exercise logs, vitals logs, and education material views. The primary outcome was change in functional capacity, measured by change in 6-minute walk distance (6MWD) from enrollment to completion. The secondary outcome was change in BP from enrollment to completion. We estimated associations using multivariable linear or logistic regression models adjusted for age, sex, race, ethnicity, socioeconomic status by ZIP code, insurance, and primary diagnosis for CR referral.

Results
A total of 107 participants (mean age 62.9, SD 13.02 years; 90/107, 84.1% male; and 57/105, 53.3% self-declared as White Caucasian) used the mobile app and completed the CR program. Participants had a mean 64.0 (SD 54.1) meter increase in 6MWD between enrollment and completion (P<.001). From enrollment to completion, participants with an elevated BP at baseline (≥130/80 mmHg) experienced a significant decrease in BP (systolic BP –11.5 mmHg; P=.002 and diastolic BP –7.7 mmHg; P=.003). We found no significant association between total app interactions and change in 6MWD (coefficient –0.03, 95% CI –0.1 to 0.07; P=.59) or change in BP (systolic coefficient 0.002, 95% CI –0.03 to 0.03; P=.87 and diastolic coefficient –0.005, 95% CI –0.03 to 0.02; P=.65). There was no significant association between total exercise logs and change in 6MWD (coefficient 0.1, 95% CI –0.3 to 0.4; P=.57) or total BP logs and change in BP (systolic coefficient –0.02, 95% CI –0.1 to 0.06; P=.63 and diastolic coefficient –0.02, 95% CI –0.09 to 0.04; P=.50). There was no significant association between total app interactions and completion of CR (adjusted odds ratio 1.00, 95% CI 0.99-1.01; P=.44).

Conclusions
CR mobile app use as part of an in-person, hybrid, or telehealth CR program was not associated with greater improvement in functional capacity or BP or with program completion.
Monitoring and features of antibiotic resistance during the COVID-19 pandemic
Authors: Bezruk V.V. , Ivanov D.D. , Shkrobanets I.D. 
Published: April 2023

Background. Urinary tract infection (UTI) is an urgent problem in nephrology. The current state of antibiotic resistance to antimicrobial drugs complicates the empirical choice of antibacterial therapy, and indications for the use of antimicrobial drugs are not always clinically justified. The purpose of the study: to compare the antibiotic resistance of the main groups of UTI pathogens during coronavirus 2019 (COVID-19) pandemic in 2020–2022 with the results of 2014–2016 monitoring among children of the Chernivtsi region. Materials and methods. Urine samples were collected from 657 children (0–17 years old) who received specialized medical care in health care institutions of the Chernivtsi region (2014–2016). During 2020–2022, a clinical and laboratory examination of 180 children (0–17 years old) was conducted. Results. The results of the monitoring proved the wave-like nature of changes in antibiotic resistance to semi-synthetic penicillins and cephalosporins with the maintenance of a sufficient level of sensitivity to these antimicrobial drugs among the main groups of UTI pathogens; the data obtained give reason to suggest a negative trend to increasing resistance to fluoroquinolones, tetracyclines over time (2020–2022 — the period of the COVID-19 pandemic); a multidirectional and time-dependent differences were revealed in sensitivity to aminoglycosides: gentamicin, amikacin and kanamycin in children of Chernivtsi region, as well as a negative trend to increasing the share of carbapenem-resistant strains of uropathogens — 55.8 ± 5.1 % (imipenem — χ2 = 5.432; p = 0.020). Conclusions. The monitoring results indicate the need to comply with standards in the provision of medical care (prescribing antibacterial therapy taking into account the data of regional monitoring on antibiotic resistance to antimicrobial drugs), administration of antimicrobial drugs in health care institutions that provide medical care in outpatient and inpatient settings. High level of antibiotic resistance of UTI uropathogens to carbapenems (2020–2022), used for the treatment of severe bacterial infections, requires their exclusively targeted prescription in everyday pediatric practice.
The Benefits of Preemptive Transplantation Using High–Kidney Donor Profile Index Kidneys
Authors: Kadatz Matthew J. , Gill Jagbir , Gill Justin , Lan James H. , McMichael Lachlan C. , Chang Doris T. , Gill John S. 
Published: April 2023

Background
The Kidney Donor Profile Index (KDPI) is a percentile score summarizing the likelihood of allograft failure: A KDPI ≥85% is associated with shorter allograft survival, and 50% of these donated kidneys are not currently used for transplantation. Preemptive transplantation (transplantation without prior maintenance dialysis) is associated with longer allograft survival than transplantation after dialysis; however, it is unknown whether this benefit extends to high-KDPI transplants. The objective of this analysis was to determine whether the benefit of preemptive transplantation extends to recipients of transplants with a KDPI ≥85%.

Methods
This retrospective cohort study compared the post-transplant outcomes of preemptive and nonpreemptive deceased donor kidney transplants using data from the Scientific Registry of Transplant Recipients. 120,091 patients who received their first, kidney-only transplant between January 1, 2005, and December 31, 2017, were studied, including 23,211 with KDPI ≥85%. Of this cohort, 12,331 patients received a transplant preemptively. Time-to-event models for the outcomes of allograft loss from any cause, death-censored graft loss, and death with a functioning transplant were performed.

Results
Compared with recipients of nonpreemptive transplants with a KDPI of 0%–20% as the reference group, the risk of allograft loss from any cause in recipients of a preemptive transplant with KDPI ≥85% (hazard ratio [HR], 1.51; 95% confidence interval [CI], 1.39 to 1.64) was lower than that in recipients of nonpreemptive transplant with a KDPI ≥85% (HR, 2.39; 95% CI, 2.21 to 2.58) and similar to that of recipients of a nonpreemptive transplant with a KDPI of 51%–84% (HR, 1.61; 95% CI, 1.52 to 1.70).

Conclusions
Preemptive transplantation is associated with a lower risk of allograft failure, irrespective of KDPI, and preemptive transplants with KDPI ≥85% have comparable outcomes with nonpreemptive transplants with KDPI 51%–84%.
Response of Growth and Production of Shallot (Allium ascalonicum L.) to Liquid Fertilizer and Cattle Manure
Authors: Candra Ifan Aulia , Lisdayani Lisdayani , Samah Eri 
Published: April 2023

The purpose of this research is to improve the physical properties and fertility of soil to improve production of shallot. The research method used is a randomized block factorial design with 3 replication. The first factor was application of liquid fertilizer (N) consisting of 3 levels (N0: 0 cm3/L water; N1: 1.5 cm3/L water; N2: 3 cm3/L water). Second factor was cattle manure (A) consisting of 4 levels, namely: A0: 0 g; A1: 40 g cattle manure; A2: 80 g cattle manure; and A3: 120 g cattle manure. The results shown treatment with liquid fertilizer has a significant effect on plant height at weeks after planting (WAP). The study showed that treatment with liquid fertilizer has a significant effect on plant height, tuber weight per clump, and tuber weight per plot, but didn’t not have a significant effect on number of leaves and number of samplings of the shallot plants. Treatment with cattle manure has a significant effect on plant height, tuber weight per clump, tuber weight per plot, and tuber diameter, but does not have a significant effect on number of leaves and number of saplings of the shallot plants. It can be concluded that the higher the application of liquid fertilizer, up to 3 cm3/L , the higher the growth and production of shallot plants, and the higher the application of cattle manure, up to 120 g/plot the higher the growth and production of shallot plants. Keywords: Plant height, Shallot, Soil Fertility, Tuber weight, Tuber size.
Application of Chitosan and Citric Acid Coating to Increase The Storage of Marigold Flowers (Tagetes Patula L.)
Authors: Darmawati Emmy Darmawati , Shacrudin Aulia Indri 
Published: April 2023

Marigold is a flower that can be consumed (edible flower) in fresh condition. Marigold flower damage is characterized by withering and changing the color of the petals to brown (browning). Coating treatment combined with citric acid is expected to be one of the solutions to maintain quality and increase the shelf life of Marigold flowers.. This study aims to examine the effect of citric acid treatment and application of coating made from chitosan on changes in the quality of Marigold flowers as fresh edible flowers. The concentrations of chitosan (K) studied were 0.05% and 0.1%; while the concentration of citric acid (A) was 1% and 2%. Citric acid solution is sprayed first. After air dried, the flowers were sprayed with a coating solution and air-dried. All flower samples, both control and treatment, were packaged and stored at 10oC. During storage, respiration rate, moisture content, weight loss and color were measured. Organoleptic test was carried out by 35 panelists with hedonic values 0-5. The best treatment was A2K2 (2% citric acid and 0.1% chitosan) which was still accepted by the panelists (score 3) until the 6th day of storage with a moisture content of 83.04%, weight loss 21.05%, and the value of °hue 79.70°. A2K2 treatment could increase the shelf life of three days longer than the control. Keywords: Chitosan, Citric acid, Coating, Edible flower, Marigold flower.
The Composition of the Chemicals, Antioxidants, and Anti-Microbial Agents on the Essential Oil of the Piper Species and Its Potential as A Natural Preservative: A Review
Authors: Susanti Rina , Sukardi Sukardi 
Published: April 2023

The production of safe food with a little to no artificial preservatives is the main and most important challenge for the food manufacturing industry. Increasing demand of using the safe preservatives has pushed the food industry to use the herbal or natural preservatives. The essential oil of the piper species consists of complex compounds like the monoterpene that has a power in the activity of the antioxidant and antibacterial. The object of research is the essential oil of piper species like the Piper nigrum, Piper betle, Piper retrofractum, Piper caninum, and Piper cubeba. The review methodology used in this research is the PRISMA flowchart (2020). PRISMA aims to identify the quality of papers and transparency of the number of articles. The objective of this research is to summarize the research related to the chemical content of the piper essential oil, the antioxidant and anti-microbe as the potential natural preservatives. The anti-microbe activity on the piper species shows the MIC score ranging from 1.5 to 12.8 mg/mL towards the standard of bacterial preservatives in preventing pathogens in foods. The essential oil of piper species has the higher antioxidant compared to the synthetic ones, like the BHA and BHT that have the score of IC₅₀ <50 mg/mL. The essential oil of piper species has the GRAS certification and “safe” as an additive in foods. Keywords: DPPH, Monoterpene, MIC, Sesquiterpene.
Relationship between oral health service quality and patient satisfaction at community health centers in Kupang city during COVID-19 pandemic
Authors: Simamora Friska Deli , Ratu Jacob Matheos , Roga Anderias Umbu , Weraman Pius , Nope Hotlif Arkilaus 
Published: April 2023

ABSTRACTIntroduction: Oral health service quality has been severely impacted by the COVID-19 pandemic, including in Kupang, one of the cities in the east part of Indonesia. Like in other cities, community health centers (Puskesmas) are the frontline to provide dental healthcare, including avoiding the spread of COVID-19. The objective of this study therefore is to analyze the correlation between oral health service quality (patient safety, effectiveness, patient centeredness, waiting time, efficiency, and equity) and patients’ satisfaction during COVID-19 pandemic. Methods: Cross sectional design was used to investigate the correlation of oral health services quality and patients’ satisfaction. Structured questionnaire was used to measure patients’ satisfaction. The number of samples involved in this study were fifty people. This study employed a non-probability sampling technique known as incidental sampling. The results of this research were obtained using multivariate multiple logistic regression analysis. Results: Patients involved in this study consist of women (60%), teenager (50%), adult (40%), educational background is senior high school (56%), junior high school (20%), employment statuses are farmer (30%) and student (28%), monthly average income is < 2 million rupiahs (and government insurance user accounting for 70%). Based on statistical analysis, there is a significant relationship between oral health service quality and patients’ satisfaction (p = 0,002). Conclusion: Patients are satisfied with oral health service quality in Kupang city during COVID-19 pandemic particularly on an equity aspect.Keywords: oral health service quality, patient satisfaction, community health center, COVID-19 pandemic