bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract Number: LBA20 Platelet Function Inhibition is superior with ticagrelor with a lower incidence of Intracerebral Hemorrhage
Authors: Fourcand Farah Y , Torres Danisette , Snyder Thomas , Vyas Shrinjay , Percival Brigitte , Gadallah Nancy , Panezai Spozhmy , Zacharatos Haralabos , Mehta Siddhart , Kirmani Jawad F 
Published: April 2023

Introduction
The most common antiplatelet agents administered for neurovascular disease treatment and prevention are aspirin, clopidogrel, and ticagrelor. The utility of monitoring various platelet function assays (PFAs) in relation to neurovascular disease is unclear and variability exists in clinical practice. The aim of this study was to evaluate PFAs as a biomarker of the platelet inhibition in aspirin, clopidogrel, and ticagrelor in patients on antiplatelet agents for a broad range of neurovascular indications.

Methods
We conducted a retrospective chart review of prospectively collected data on patients who presented to our comprehensive stroke center and had PFAs drawn. PFAs utilized include Aspirin VerifyNow test, measured in aspirin resistance units (ARU) and Plavix VerifyNow test, measured in P2Y12 reaction units (PRU). Values less than 550 ARU are consistent with aspirin‐induced platelet inhibition. Similarly, values less than 197 PRU are indicative of platelet inhibition in clopidogrel or ticagrelor. Compliance and incidence of intracranial hemorrhage (ICH) were assessed. Social science statistics software was used for data analysis.

Results
From January to June 2022, a total of 297 patients had platelet function assays drawn for neurovascular indications. Average age was 69.96 (95% CI 68.31, 71.61). One hundred and eighty nine subjects were on aspirin. Mean ARU was 448.73 (95% CI 438.53, 458.93). One hundred twenty three subjects were on clopidogrel. Mean PRU for clopidogrel was 162.84 (95% CI 147.33, 178.35). Fifteen subjects were on ticagrelor. Mean PRU for ticagrelor was 73.27 (95% CI 34.62, 111.91). There was a significant difference in therapeutic efficacy between clopidogrel and ticagrelor in subjects who were compliant (n = 105 clopidogrel complaint; n = 14 ticagrelor complaint) (z‐score 3.63, p‐value 0.00028). There was a significant difference between incidence of ICH in subjects compliant and therapeutic on clopidogrel as compared to ticagrelor (n = 8 clopidogrel and ICH; n = 1 ticagrelor and ICH) (Fisher value = 0.0205).

Conclusions
Our study suggests that platelet inhibition of ticagrelor may be superior to that of clopidogrel with a lower incidence of intracranial hemorrhage as a complication of therapy. Significant limitations include the discrepancy in respective sample sizes. Larger, prospective studies are needed to validate our results.
Abstract Number: LBA21 Platelet Function Assays for Aspirin and Ticagrelor are More Reliable When Compared with Clopidogrel
Authors: Fourcand Farah Y , Torres Danisette , Snyder Thomas , Vyas Shrinjay , Percival Brigitte , Gadallah Nancy , Strauss Sara , Panezai Spozhmy , Zacharatos Haralabos , Mehta Siddhart , Kirmani Jawad F 
Published: April 2023

Introduction
The most common antiplatelet agents administered for neurovascular disease treatment and prevention are aspirin, clopidogrel, and ticagrelor. The utility of monitoring various platelet function assays (PFAs) in relation to neurovascular disease is unclear and variability exists in clinical practice. The aim of this study was to evaluate reliability of PFAs as a biomarker of the platelet inhibition in aspirin, clopidogrel, and ticagrelor in patients on antiplatelet agents for a broad range of neurovascular indications.

Methods
We conducted a retrospective chart review of prospectively collected data on patients who presented to our comprehensive stroke center and had PFAs drawn. PFAs utilized include Aspirin VerifyNow test, measured in aspirin resistance units (ARU) and Plavix VerifyNow test, measured in P2Y12 reaction units (PRU). Values less than 550 ARU are consistent with aspirin‐induced platelet inhibition. Similarly, values less than 197 PRU are indicative of platelet inhibition in clopidogrel or ticagrelor. Compliance and incidence of intracranial hemorrhage (ICH) and other adverse bleeding events were assessed. Social science statistics software was used for data analysis.

Results
From January to June 2022, a total of 297 patients had platelet function assays drawn for neurovascular indications. Average age was 69.96 (95% CI 68.31, 71.61). One hundred and eighty nine subjects were on aspirin. Mean ARU was 448.73 (95% CI 438.53, 458.93). One hundred twenty three subjects were on clopidogrel. Mean PRU for clopidogrel was 162.84 (95% CI 147.33, 178.35). Fifteen subjects were on ticagrelor. Mean PRU for ticagrelor was 73.27 (95% CI 34.62, 111.91). There was a significant difference in therapeutic platelet inhibition between clopidogrel and ticagrelor in subjects who were compliant (n = 105 clopidogrel complaint; n = 14 ticagrelor complaint) (z‐score 3.63, p‐value 0.00028). Of the patients that were compliant none had a non therapeutic platelet inhibition on aspirin and ticagrelor. Of the 123 patients that were compliant on clopidogrel 76% had non therapeutic PFA (n = 8 clopidogrel and ICH; n = 1 ticagrelor and ICH) (Fisher value = 0.0205).

Conclusions
Our study suggests that platelet inhibition of aspirin and ticagrelor may be more reliable when compared to that of clopidogrel. Significant limitations include the discrepancy in respective sample sizes. Larger studies are needed to validate our results.
Good fences make good neighbours: territorial male Cape fur seals use spatial acoustic map of neighbours
Authors: Martin M. , Gridley T. , Elwen S.H. , Charrier I. 
Published: April 2023

Abstract
In territorial species, individual recognition among neighbouring males is likely to reduce energy expenses and risk of injury associated with the costly period of maintaining territory during the breeding season. This study explored neighbour–stranger vocal recognition in male Cape fur seals, one of the most colonial and polygynous mammals. Playback experiments revealed that territorial males were able to recognise the calls of their neighbours, in combination with their relative spatial position to their own harem. No ‘dear-enemy’ nor ‘nasty neighbour’ effects were detected. However, the strongest responses observed were towards the calls of familiar neighbours played back from an incongruent location, simulating a situation in which a neighbour is outside its own territory. The colony structure and movements of the seals across the day could explain such results. This study has implications for understanding how vocal signals regulate interactions among males in polygynous mammals, particularly during the competitive mating period.
Bottom-Up and Top-Down Approaches to Y&C Ministry, Part 1
Authors: Barfield Robin , Crispin Gareth 
Published: April 2023

Abstract
Given the rise and importance of the agency of the self and more immanent approaches to theology, the landscape of youth and children’s mission and ministry can now be usefully analysed in terms of ‘top-down’ and ‘bottom-up’ approaches – rather than (or at least alongside) using ‘inside-out’ and ‘outside-in’ as the main analytical categories. Top-down approaches look to do ministry ‘to’ youth and children and are commensurate with more transcendent approaches to theology and Durkheimian structural-functionalist school of thought within sociology – these approaches risk under-emphasising agency and immanence. Bottom-up approaches are more concerned with doing ministry ‘with’ youth and children and are commensurate with more immanent approaches to theology and Weberian social interactionist and conflict theory models of society – these approaches risk over-emphasising agency and immanence.
Dendrochronological Dating of Northern Netherlandish Furniture from the Late-17th and Early-18th Centuries
Authors: van Duin Paul , Domínguez-Delmás Marta , Breebaart Iskander 
Published: April 2023

Abstract
Over the last 30 years, more than 70 pieces of furniture from the Rijksmuseum collection (Amsterdam, the Netherlands) have been dated using dendrochronology. Furniture from the northern Netherlands was seldom dated by the maker and never signed, and only a few documents indicating who and when it was made have survived. Here, we present an overview of the research carried out on 17th-century furniture objects from the Rijksmuseum, with a special focus on the results pertaining to marquetry cabinets produced around the 1700s. We outline the general approach followed to conduct dendrochronological research on cabinets — from the selection of elements to the interpretation of the results. On average, a cabinet consists of fifty to 100 wooden elements. In many of these elements, the end grain is not accessible, and partial dismantling may be required to access the surface and the tree-ring pattern; hence, conscious choices must be made. Seven pieces of furniture are discussed in this paper, including the first cabinet dated by dendrochronology at the Rijksmuseum (the dolls’ house commissioned by Petronella Oortman), a cabinet with inlaid Japanese lacquer panels, and furniture by Jan van Mekeren with intricate marquetry depicting large bouquets of flowers. The results of the dendrochronological research show that the oak used in these cabinets was predominantly sourced in Germany and, to a lesser extent, eastern France. The dates and provenance of the wood were cross-checked with existing art historical dates, which were then refined. The results highlight the added value of dendrochronological analyses of furniture and the contribution of this scientific method to understanding developments in cabinetmaking by chronologically arranging objects made by the same manufacturer. They also point to the need to continue developing and improving regional and local reference tree-ring chronologies to produce more accurate inferences regarding wood provenance.
Climate Change, Fish Production, and Maritime Piracy
Authors: Jiang Bo , LaFree Gary 
Published: April 2023

Abstract
Contemporary social science has produced little research on connections between climate change and crime. Nonetheless, much prior research suggests that economic insecurity may affect individual calculations of the cost and benefit of engaging in criminal behavior, and climate change is likely to have important economic consequences for professions like fishing that depend directly on the environment. In this paper, we test the possibility that climate change affects participation in maritime piracy, depending on the specific ways that it impacts regional fish production. Our analysis is based on piracy in East Africa and the South China Sea. These two regions are strategic in that both areas have experienced a large amount of piracy; however, rising sea temperatures have been associated with declines in fish production in East Africa but increases in the South China Sea. We treat sea surface temperature as an instrument for fish output and find that in East Africa higher sea surface temperature is associated with declining fish production, which in turn increases the risk of piracy, whereas in the South China Sea higher sea surface temperature is associated with increasing fish production, which in turn decreases the risk of piracy. Our results also show that decreases in fish production bring about a larger number of successful piracy attacks in East Africa and that increases in fish production are associated with fewer successful attacks in the South China Sea. We discuss the theoretical and policy implications of the findings and point out that as climate change continues, its impact on specific crimes will likely be complex, with increases and decreases depending on context.

Significance Statement
There is little evidence on the effect of climate change on criminal behavior. This study seeks to quantify the impact of a specific type of climate change—rising sea temperature—on maritime piracy, a type of crime that is linked exclusively to the ocean. The risk of piracy attacks and the probability of successful attacks are higher with declines in fish production in East Africa and lower with increases in fish production in the South China Sea. These results suggest that climate change does affect maritime piracy rates and that its effect depends on the specific situational context and the rational choices that changing sea temperatures generate.
Clinical benefits and risks of anticoagulation therapy according to the degree of chronic kidney disease in patients with atrial fibrillation
Authors: Cho Min Soo , Choi Hyung Oh , Hwang Ki Won , Kim Jun , Nam Gi-Byoung , Choi Kee-Joon 
Published: April 2023

Abstract
Background
The clinical benefits and risks of anticoagulation therapy in patients with chronic kidney disease (CKD) are still inconclusive. We describe the outcomes of patients with atrial fibrillation (AF) after anticoagulation therapy according to differences in creatinine clearance (CrCl). We also aimed to determine the patients who could benefit from anticoagulation therapy.

Methods
This is a retrospective observational review of patients with AF who were managed at Asan Medical Center (Seoul, Korea) between January 1, 2006, and December 31, 2018. Patients were categorized into groups according to their baseline CrCl by Cockcroft–Gault equation and their outcomes were evaluated (CKD 1, ≥ 90 mL/min; CKD2, 60–89 mL/min; CKD3, 30–59 mL/min; CKD4, 15–29 mL/min; CKD 5, < 15 mL/min). The primary outcome was NACE (net adverse clinical events), defined as a composite of all-cause mortality, thromboembolic events, and major bleeding.

Results
We identified 12,714 consecutive patients with AF (mean 64.6 ± 11.9 years, 65.3% male, mean CHA2DS2-VASc score 2.4 ± 1.6 points) between 2006 and 2017. In patients receiving anticoagulation therapy (n = 4447, 35.0%), warfarin (N = 3768, 84.7%) was used more frequently than NOACs (N = 673, 15.3%). There was a higher 3-year rate of NACE with renal function deterioration (14.8%, 18.6%, 30.3%, 44.0%, and 48.8% for CKD stages 1–5, respectively).The clinical benefit of anticoagulation therapy was most prominent in patients with CKD 1 (hazard ratio [HR] 0.49, 95% confidence interval [CI] 0.37–0.67), 2 (HR 0.64 CI 0.54–0.76), and 3 (HR 0.64 CI 0.54–0.76), but not in CKD 4 (HR 0.86, CI 0.57–1.28) and 5 (HR 0.81, CI 0.47–1.40). Among patients with CKD, the benefit of anticoagulation therapy was only evident in those with a high risk of embolism (CHA2DS2-VASc score ≥ 4, HR 0.25, CI 0.08–0.80).

Conclusion
Advanced CKD is associated with a higher risk of NACE. The clinical benefit of anticoagulation therapy was reduced with the increasing CKD stage.
Ambulance referral of more than 2 hours could result in a high prevalence of medical-device-related pressure injuries (MDRPIs) with characteristics different from some inpatient settings: a descriptive observational study
Authors: Luo Zhenyu , Liu Sihui , Yang Linhe , Zhong Shuyan , Bai Lihua 
Published: April 2023

Abstract
Background
Medical device-related pressure injuries(MDRPI) are prevalent and attracting more attention. During ambulance transfer, the shear force caused by braking and acceleration; extensive medical equipment crowed in a narrow space add external risk factors for MDRPIs. However, there is insufficient research on the relationship between MDRPIs and ambulance transfers. This study aims to clarify the prevalence and characteristics of MDRPI during ambulance transfer.

Method
A descriptive observational study was conducted with convenience sampling. Before starting the study, six PI specialist nurses certified by the Chinese Nursing Association trained emergency department nurses for three MDRPI and Braden Scale sessions, one hour for each session. Data and images of PIs and MDRPIs are uploaded via the OA system by emergency department nurses and reviewed by these six specialist nurses. The information collection begins on 1 July 2022 and ends on 1 August 2022. Demographic and clinical characteristics and a list of medical devices were collected by emergency nurses using a screening form developed by researchers.

Results
One hundred one referrals were eventually included. The mean age of participants was (58.3 ± 11.69) years, predominantly male (67.32%, n = 68), with a mean BMI of 22.48 ± 2.2. The mean referral time among participants was 2.26 ± 0.26 h, the mean BRADEN score was 15.32 ± 2.06, 53.46% (n = 54) of participants were conscious, 73.26% (n = 74) were in the supine position, 23.76% (n = 24) were in the semi-recumbent position, and only 3 (2.9%) were in the lateral position. Eight participants presented with MDRPIs, and all MDRPIs are stage 1. Patients with spinal injuries are most prone to MDRPIs (n = 6). The jaw is the area most prone to MDRPIs, caused by the cervical collar (40%, n = 4), followed by the heel (30%, n = 3) and nose bridge (20%, n = 2) caused by the respiratory devices and spinal board.

Conclusion
MDRPIs are more prevalent during long ambulance referrals than in some inpatient settings. The characteristics and related high-risk devices are also different. The prevention of MDRPIs during ambulance referrals deserves more research.
High leukocyte mitochondrial DNA copy number contributes to poor prognosis in breast cancer patients
Authors: Zhang Wenzhe , Lin Songping , Zeng Bangwei , Chen Xiaobin , Chen Lili , Chen Minyan , Guo Wenhui , Lin Yuxiang , Yu Liuwen , Hou Jialin , Li Yan , Li Shengmei , Jin Xuan , Cai Weifeng , Zhang Kun , Nie Qian , Chen Hanxi , Li Jing , He Peng , Cai Qindong , Qiu Yibin , Wang Chuan , Fu Fangmeng 
Published: April 2023

Abstract
Background
Compelling evidence has indicated a significant association between leukocyte mitochondrial DNA copy number (mtDNAcn) and prognosis of several malignancies in a cancer-specific manner. However, whether leukocyte mtDNAcn can predict the clinical outcome of breast cancer (BC) patients has not been well investigated.

Methods
The mtDNA copy number of peripheral blood leukocytes from 661 BC patients was measured using a Multiplex AccuCopy™Kit based on a multiplex fluorescence competitive PCR principle. Kaplan–Meier curves and Cox proportional hazards regression model were applied to investigate the association of mtDNAcn with invasive disease-free survival (iDFS), distant disease-free survival (DDFS), breast cancer special survival (BCSS), and overall survival (OS) of patients. The possible mtDNAcn-environment interactions were also evaluated by the Cox proportional hazard regression models.

Results
BC patients with higher leukocyte mtDNA-CN exhibited a significantly worse iDFS than those with lower leukocyte mtDNAcn (5-year iDFS: fully-adjusted model: HR = 1.433[95%CI 1.038–1.978], P = 0.028). Interaction analyses showed that mtDNAcn was significantly associated with hormone receptor status (adjusted p for interaction: 5-year BCSS: 0.028, 5-year OS: 0.022), so further analysis was mainly in the HR subgroup. Multivariate Cox regression analysis demonstrated that mtDNAcn was an independent prognostic factor for both BCSS and OS in HR-positive patients (HR+: 5-year BCSS: adjusted HR (aHR) = 2.340[95% CI 1.163–4.708], P = 0.017 and 5-year OS: aHR = 2.446 [95% CI 1.218–4.913], P = 0.011).

Conclusions
For the first time, our study demonstrated that leukocyte mtDNA copy number might influence the outcome of early-stage breast cancer patients depending on intrinsic tumor subtypes in Chinese women.
Screening of attention deficit hyperactivity disorder among preschool children Gharbia Governorate, Egypt
Authors: Younis Eman Ali , Shalaby Safynaz El Saied , Abdo Sanaa Abd El‐fatah 
Published: April 2023

Abstract
Background
Children who experience mental health issues, such as attention deficit hyperactivity disorder (ADHD), experience significant distress and impairment at home, at school, and in the community. Without adequate care or prevention, this frequently results in adulthood-long distress and impairment at large societal costs. Determining the prevalence of ADHD cases among preschoolers as well as some associated maternal and child risk factors was the aim of this study.

Methods
An analytical cross-sectional study including 1048 preschool children aged 3–6 years was carried out in Tanta City, Gharbia Governorate. From March to April 2022, a proportionate stratified cluster random sample of them was picked. Data were gathered using a predesigned instrument that included sociodemographic information, family history, maternal and child risk factors, and the Arabic version of the ADHD Rating Scale IV questionnaire.

Results
The prevalence of ADHD among preschoolers was 10.5%. The inattention type was the most common (5.3%), followed by the hyperactivity type (3.4%). There were statistically significant associations regarding positive family history of psychological and neurological symptoms (17.9% positive vs. 9.7% negative), family history of ADHD symptoms (24.5% positive vs. 9.4% negative), active smoking by the mother (21.1% positive vs. 5.3% negative), cesarean section delivery (66.4% positive vs. 53.9% negative), elevated blood pressure during pregnancy (19.1% positive vs. 12.4% negative), and history of taking drugs during pregnancy (43.6% positive vs. 31.7% negative). Significant child risk factors were: exposure to any source containing lead that causes slow poisoning (25.5% positive vs. 12.3% negative), children with cardiac health problems (38.2% positive vs. 16.6% negative), and hours spent by a child in front of the TV or mobile phone (any screens) per day (60.0% of those with positive screening spent more than 2 h/day vs. 45.7% negative).

Conclusion
In the Gharbia governorate, 10.5% of preschoolers suffer from ADHD. Significant maternal risk factors for ADHD included a positive family history of psychiatric and neurological symptoms, a family history of ADHD symptoms, active maternal smoking, caesarean section delivery, increased blood pressure during pregnancy, and a history of drug use during pregnancy. Youngsters who had cardiac health issues and who spent more time each day watching TV or using a mobile device (screen use) were at substantial risk.