bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fold, Twist, and Draw – Techniques of Copper Alloy Wire Production from Hellenistic Jebel Khalid
Authors: Mazis Matasha , Klein Matthias 
Published: April 2023

Abstract
Copper alloy wire fragments were examined using XRF, optical light microscopy and SEM-EDS. The specimens come from archaeological excavations at Jebel Khalid in Syria, dating from the 3rd century BCE (the Hellenistic period) to the Roman period. Our results show that several techniques were employed to make the wires: forging, folding, strip twisting, and possibly ‘strip drawing’. We investigated the morphologies, treatments, and fabrications attributed to making wire from copper alloys compared to more ductile materials such as gold and silver. Evidence of extensive annealing and non-uniform, sub-round profiles, and uneven and faceted surfaces represent the challenges of working with the material. There is no obvious evidence of solid wire drawing. The metalworkers used different copper alloys to make wire, some with high levels of lead (Pb). Subtle joins were observed in some samples, whereas others had evident folds and directional structures. The findings contribute new evidence to enhance our understanding of base-metal wire development in antiquity.
Non-invasive Archaeometric Studies of Metal Threads with Silk Core Coming from Two Kontush Sashes from the Szczuczyn Excavations in Poland
Authors: Miazga Beata , Grupa Małgorzata 
Published: April 2023

Abstract
A kontush sash belonged to costly accessories of ceremonial clothes of Polish nobility. It is a belt made of leather, metal or soft textile, called a sash from the 18th century. In the 2nd half of the 17th century, there was a change in manufacturing technique and ornamentation compositions, and sashes adorned with metal threads appeared. Persian and Turkish belts were the most popular. They have been excavated as burial equipment at archaeological sites. Analyzing these objects is a unique research experience that complements our knowledge of girdle-making in the eighteenth century. The non-invasive archaeometric studies are a significant part of this research. The microscopic observations, X-ray fluorescence and SEM-EDS investigations were made of the metal threads from the textile sashes found in the crypts of Szczuczyn church (North-Eastern Poland).
The Histories of Well-Documented Maritime Cyclones as Portrayed by an Automated Tracking Method
Authors: Roebber Paul J. , Grise Kevin M. , Gyakum John R. 
Published: April 2023

Abstract
This study examines extratropical cyclone tracks, central pressure, and maximum intensification rates from a widely used automated cyclone tracking scheme and compares them with the manual tracking of five well-known North Atlantic cyclones whose histories are available in the refereed literature. The automated tracking scheme is applied to sea level pressure data from four different reanalyses of varying levels of sophistication to test the sensitivity of the results to input data resolution and quality. Further, we test the tracking scheme using lower-tropospheric vorticity obtained from the most recent reanalysis (ERA5) for four of these cyclone events. Substantial discrepancies in cyclone position, intensity, and maximum intensification rates exist between the manual tracking and the automated tracking and are not eliminated by using higher-resolution reanalyses or by “turning off” the spatial smoothing feature of the automated tracking scheme (needed to reduce spurious cyclone detections). The results point to a particular problem in detecting weaker and earlier stage cyclones and confirm findings from studies that have examined a broad range of cyclone tracking schemes for a range of reanalyses. Notably, this early cyclone stage often involves a smaller-scale secondary cyclogenesis or cyclone wave, which are detected by the automated scheme only after subsequent growth in the ensuing 6–12 h. It is known that these early stages are critical for a comprehensive understanding of rapid intensification events. A discussion of possible future solutions to this problem is presented.

Significance Statement
Because of the availability of large modern datasets portraying sea level pressure across the globe, meteorologists have turned to automated detection and tracking of midlatitude cyclones. Detection and tracking are of interest since these storm systems play an important role in weather and climate and potential changes in their location, frequency, and intensity are of considerable societal interest given climate change. This paper compares the results obtained from one commonly used automated tracking method with tracks obtained by human analysts. We find substantial discrepancies in cyclone position, intensity, and intensification rates and that these differences are not eliminated by using improved analyses. A discussion of possible future solutions is presented.
Lipid Peroxidation Inhibitory and Cytotoxic Activities of Two Camellia Species Growing Wild in Vietnam
Authors: An Nguyen Thi Giang , Chau Dao Thi Minh , Huong Le Thi , Van Khoa Vu , Hung Nguyen Huy , Thao Do Thi , Trang Vo Thi Quynh , Dai Do Ngoc , Setzer William N. 
Published: April 2023

Background Leaves, flowers and young shoots of yellow Camellia species are often used as a substitute for green tea in Vietnam. Yellow Camellia species contain high levels of polyphenol compounds, and have shown activities such as antioxidant, anticancer, and cytotoxic. Objectives We qualitatively screened phytochemicals, quantified total polyphenols of 70% ethanol (EtOH) extracts of leaves, young shoots, and flowers of Camellia vuquangensis and Camellia hatinhensis in Ha Tinh Province, Vietnam. Furthermore, these extracts have been evaluated for lipid peroxidation inhibitory activities at the in vivo level in the BALB/c mouse model, and in vitro cytotoxic activities. Materials and Methods Chemical methods and thin-layer chromatographic (TLC) analysis were used for the qualitative screening of phytochemicals. High-performance liquid chromatography (HPLC) was used to determine total polyphenols. Cell survival was determined through optical density (OD) measured when the protein composition of the cells was stained with sulforhodamine B (SRB). Inhibition of lipid peroxidation was evaluated by determining the content of malondialdehyde (MDA), which is a product of membrane lipid peroxidation. Results The total polyphenol contents of all parts of the two species were comparable to that of green tea with values between 319.3 and 342.6 mg gallic acid equivalents (GAE/g) dry weight. Extracts of leaves, flowers of C. vuquangensis and C. hatinhensis showed strong lipid peroxidation inhibitory activities (IC50: 7.92–17.45 µg/mL) and moderate cytotoxic activities against cell lines HepG2, A549, MCF7, SK-Mel-2, HT-29, and AGS (IC50: 34.73–80.58 µg/mL). Conclusion These two tea species may be considered as herbal teas with various health benefits.
Comparison of distance education and in-person education in procedural sedation and analgesia: A randomized controlled trial
Authors: Takeuchi Shinya , Norii Tatsuya , Rivera Marisa , Homma Yosuke 
Published: April 2023

Background: Despite the increasing demand for procedural sedation and analgesia training, the number of available instructors remains limited. Objective: The aim of this study is to compare distance education with in-person learning for knowledge acquisition and participant satisfaction in procedural sedation and analgesia education. Methods: We conducted a randomized controlled trial comparing distance education with in-person learning in Japan on three occasions. Twenty participants per course were randomly divided into five groups with stratification by year of graduation. The groups were randomized to either a distance education group or an in-person group. We conducted pre- and post-testing of procedural sedation and analgesia knowledge and surveyed participants’ perceptions by using a scale ranging from 0 (not enough) to 100 (enough). Our primary outcomes were knowledge acquisition and the quality of discussion. Results: We included 48 healthcare professionals in the analysis. Forty-one participants (83.6%) were men and the median years of experience was 5 (interquartile range: 3–9). Both groups had similar knowledge acquisition with the pre-test and post-test score difference and reported similar scores on the quality of discussion with the exception of the clarity of audio quality (93 vs 100, p = 0.017). Conclusion: In a randomized trial of distance versus in-person learning for the sedation course, we did not observe statistically significant differences in knowledge acquisition and participant satisfaction between the two groups except for audio quality for the case discussion. Further efforts to improve quality for distance learning in procedural sedation and analgesia education are needed.
Pan-Cancer Study of the Prognosistic Value of Selenium Phosphate Synthase 1
Authors: Hao Jie , He Ao-Yue , Zhao Xu , Chen Xue-Qin , Liu Qi-Ling , Sun Na , Zhang Rong-Qiang , Li Ping-Ping 
Published: April 2023

Objective: This study sought to determine the mean prognostic usefulness of seleniumphosphate synthase ( SEPHS1) by investigating its expression in 33 human malignancies and its relationship to tumor immunity. Methods: The expression of selenophosphate synthase 1 ( SEPHS1) in 33 human malignant tumors was examined using the Genotype-Tissue Expression (GTEx), Cancer Genome Atlas (TCGA), and TIMER databases. Furthermore, the TCGA cohort was used to investigate relationships between SEPHS1 and immunological checkpoint genes (ICGs), tumor mutation burden (TMB), microsatellite instability (MSI), and DNA mismatch repair genes (MMRs). To establish independent risk factors and calculate survival probabilities for liver hepatocellular carcinoma (LIHC) and brain lower-grade glioma (LGG), Cox regression models and Kaplan-Meier curves were utilized. Eventually, the Genomics of Cancer Drug Sensitivity (GDSC) database was used to evaluate the drug sensitivity in LGG and LIHC patients with high SEPHS1 expression. Results: Overall, in numerous tumor tissues, SEPHS1 was highly expressed, and it significantly linked with the prognosis of LGG, ACC, and LIHC ( P < .05). Furthermore, in numerous cancers, SEPHS1 expression was linked to tumor-infiltrating immune cells (TIICs), TMB, MSI, and MMRs. According to univariate and multivariate Cox analyses, SEPHS1 expression was significant for patients with LGG and LIHC. Conclusion: High SEPHS1 expression has a better prognosis for LGG, while low SEPHS1 expression has a better prognosis for LIHC. Chemotherapy was advised for LGG patients, particularly for those with high SEPHS1 expression because it can predict how responsive patients will be to 5-Fluorouracil and Temozolomide. This interaction between SEPHS1 and chemoradiotherapy has a positive clinical impact and may be used as evidence for chemotherapy for LGG and LIHC patients.
Mental Health Among People Presenting for Care of Physical Symptoms: The Factors Associated with Suicidality and Symptoms of Depression and Anxiety are Similar Across Specialties
Authors: Ramtin Sina , Carberry Kathleen , Correa Maria , Ring David , Alter Carol , Shanor Donna 
Published: April 2023

Background To identify differences in thoughts of suicide and symptoms of depression and anxiety by specialty among people presenting for care of physical symptoms, we analyzed data from routine mental health measurement in a small multispecialty practice and asked: 1. Are there any differences in suicidality (analyzed as an answer of 1 or greater or 2 or greater on the Patient Health Questionnaire [PHQ] question 9) in non-specialty and various types of specialty care? 2. Are there any factors—including specialty–associated with symptoms of depression (mean PHQ score), PHQ thresholds (greater than 0, 3 or greater, 10 or greater), Generalized Anxiety Disorder instrument [GAD] score of 3 or greater, and either GAD score 3 or greater or PHQ score 3 or greater? and 3. What factors are associated with referral to a social worker? Methods As part of routine specialty and non-specialty care, 13,211 adult patients completed a measure of symptoms of depression (PHQ) that included a question about suicidality and a measure of symptoms of anxiety (GAD). Factors associated with suicidality and symptoms of depression and anxiety at various thresholds, and visit with a social worker, were sought in multivariable models. Results Accounting for potential confounding in multivariable analyses, a score higher than 0 on the suicidality question (present in 18% of people) was associated with men, younger age, English-speakers, and neurodegenerative specialty care. Symptoms of depression on their continuum and using various thresholds (28% of people had a PHQ score greater than 2) were associated with non-Spanish-speakers, younger age, women, and county insurance or Medicaid insurance. Care from the social worker was associated with PHQ score of 3 or greater and having any suicidal thoughts (score of 1 or greater on question 9) but was less common with Medicare or Commercial Insurance and less common in the unit treating cognitive decline. Conclusion The notable prevalence of symptoms of depression and suicidality among people presenting for care of physical symptoms across specialties and the relatively similar factors associated with suicidality, symptoms of depression, and symptoms of anxiety at various thresholds suggests that both non-specialty and specialty clinicians can be vigilant for opportunities for improved mental health. Increased recognition that people seeking care for physical symptoms often have mental health priorities has the potential to improve comprehensive care strategies, alleviate distress, and reduce suicide.
Biomarkers of moderate alcohol intake and alcoholic beverages: a systematic literature review
Authors: Trius-Soler Marta , Praticò Giulia , Gürdeniz Gözde , Garcia-Aloy Mar , Canali Raffaella , Fausta Natella , Brouwer-Brolsma Elske M. , Andrés-Lacueva Cristina , Dragsted Lars Ove 
Published: April 2023

AbstractThe predominant source of alcohol in the diet is alcoholic beverages, including beer, wine, spirits and liquors, sweet wine, and ciders. Self-reported alcohol intakes are likely to be influenced by measurement error, thus affecting the accuracy and precision of currently established epidemiological associations between alcohol itself, alcoholic beverage consumption, and health or disease. Therefore, a more objective assessment of alcohol intake would be very valuable, which may be established through biomarkers of food intake (BFIs). Several direct and indirect alcohol intake biomarkers have been proposed in forensic and clinical contexts to assess recent or longer-term intakes. Protocols for performing systematic reviews in this field, as well as for assessing the validity of candidate BFIs, have been developed within the Food Biomarker Alliance (FoodBAll) project. The aim of this systematic review is to list and validate biomarkers of ethanol intake per se excluding markers of abuse, but including biomarkers related to common categories of alcoholic beverages. Validation of the proposed candidate biomarker(s) for alcohol itself and for each alcoholic beverage was done according to the published guideline for biomarker reviews. In conclusion, common biomarkers of alcohol intake, e.g., as ethyl glucuronide, ethyl sulfate, fatty acid ethyl esters, and phosphatidyl ethanol, show considerable inter-individual response, especially at low to moderate intakes, and need further development and improved validation, while BFIs for beer and wine are highly promising and may help in more accurate intake assessments for these specific beverages.
Mechanical protective effect of lens anterior capsule disc on corneal endothelial cells during femtosecond laser-assisted cataract surgery in a rabbit model
Authors: Wu Bowen , Ding Xue , Li Shaowei , Huo Dongmei , Zhang Fan , Liang Weiyan , Li Ling , Dou Zexia 
Published: April 2023

Abstract
Purpose
To evaluate the effects of a novel technique using an isolated lens anterior capsule disc (LACD) to protect corneal endothelial cells in rabbit eyes during femtosecond laser-assisted cataract surgery.

Methods
Experimental study. 40 rabbits were divided into endothelium-protected (experimental) and control groups, with 20 rabbits in each group. In the experimental group, after femtosecond laser capsulotomy, the isolated capsule disc was lifted to the corneal endothelium by an ophthalmic viscosurgical device. The endothelium was damaged for 1 min with an ultrasonic probe. The control group underwent the same surgery, except that the disc was removed immediately after capsulorhexis. Corneal endothelioscopy was performed preoperatively and on postoperative days (PODs) 3 and 7 to observe endothelial cell counts (ECC) and endothelial cell loss rate. Central corneal thickness (CCT) was measured before and at PODs 1, 3 and 7.

Results
There were 3.59%±1.88% (p < 0.001) and 2.92%±2.14% (p < 0.001) loss of ECC in experimental group at POD3 and POD7, respectively, while those in the control group were 11.62%±7.43% and 10.34%±5.77%, respectively. On POD 1, the difference in central corneal thickness was significant(P = 0.019) between the two groups. At POD 3 and POD 7, CCT was not significantly different (P = 0.597;0.913) between the two groups.

Conclusions
The isolated LACD technique significantly reduced damage to the endothelium caused by ultrasonic energy and protects corneal endothelial cells during phacoemulsification.
Insights into barriers and facilitators in PrEP uptake and use among migrant men and transwomen who have sex with men in Belgium
Authors: Van Landeghem Ella , Dielen Stef , Semaan Aline , Rotsaert Anke , Vanhamel Jef , Masquillier Caroline , Wouters Edwin , Wouters Kristien , Vuylsteke Bea , Reyniers Thijs , Nöstlinger Christiana 
Published: April 2023

Abstract
Background
PrEP uptake is low among non-Belgian men and transwomen who have sex with men, although the HIV epidemic among men who have sex with men in Belgium is diversifying in terms of nationalities and ethnicity. We lack an in-depth understanding of this gap.

Methods
We conducted a qualitative study using a grounded theory approach. The data consists of key informants interviews and in-depth interviews with migrant men or transwomen who have sex with men.

Results
We identified four underlying determinants which shape our participants’ experiences and contextualize the barriers to PrEP use. These include (1) the intersectional identities of being migrant and men and transwomen who have sex with men, (2) migration related stressors, (3) mental health and (4) socio-economic vulnerability. Identified barriers include: the accessibility of services; availability of information, social resources and providers’ attitudes. These barriers influence PrEP acceptance and mediated by individual agency this influences their PrEP uptake.

Conclusion
An interplay of several underlying determinants and barriers impacts on PrEP uptake among migrant men and transwomen who have sex with men, illustrating a social gradient in access to PrEP. We need equitable access to the full spectrum of HIV prevention and care for all priority populations, including undocumented migrants. We recommend social and structural conditions that foster exercising these rights, including adapting PrEP service delivery, mental health and social support.
Heart health for South Asians: improved cardiovascular risk factors with a culturally tailored health education program
Authors: Vafaei Paniz , Liu Chi-Mei , Davis Hank , Patel Priyal , Vadlakonda Uma , Pursnani Seema 
Published: April 2023

Abstract
Background/Aim
The Kaiser Permanente (KP) Northern California Heart Health for South Asians (HHSA) Program is a two-hour educational class that provides culturally relevant lifestyle and dietary recommendations to South Asian (SA) patients, in an effort to reduce their known disproportionate burden of cardiovascular (CV) disease. We evaluated the impact of the HHSA Program on CV risk factors and major adverse CV events (MACE).

Methods
A retrospective cohort study identified 1517 participants of SA descent, ≥ 18 years old from 2006 to 2019. We evaluated the change in risk factors with program attendance (median follow up of 6.9 years) for systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), LDL, HDL, BMI, and HbA1c. We also performed a propensity matched analysis to evaluate differences in MACE including stroke, myocardial infarction (MI), coronary revascularization, and all-cause mortality.

Results
There were significant improvements in DBP, TG, LDL-c, HDL-c, BMI, and HbA1c at one year follow up and sustained improvements in DBP (-1.01mmHg, p = 0.01), TG (-13.74 mg/dL, p = 0.0001), LDL-c (-8.43 mg/dL, p = < 0.0001), and HDL-c (3.16 mg/dL, p = < 0.0001) levels at the end of follow up. In the propensity matched analysis, there was a significant reduction in revascularization (OR 0.33, 95% CI 0.14–0.78, p = 0.011) and mortality (OR 0.41, 95% CI 0.22–0.79, p = 0.008), and a trend towards reduction in stroke.

Conclusions
Our study demonstrates the efficacy of a culturally tailored SA health education program in improving CV risk factors and reducing MACE. The program highlights the importance and value of providing culturally tailored health education in primary CV disease prevention.
Efficacy of surgical methods for peri-implantitis: a systematic review and network meta-analysis
Authors: Cheng Jing , Chen Liang , Tao Xian , Qiang Xiang , Li Ruiying , Ma Jia , Shi Dong , Qiu Zijin 
Published: April 2023

Abstract
Background
Peri-implantitis is the most difficult biological complication associated with dental implants, often requiring surgical treatments in advanced stages. This study compares the effectiveness of different surgical methods for peri-implantitis.

Methods
Randomized controlled trials (RCTs) of different surgical treatments for peri-implantitis were extracted from EMBASE, Web of Science, Cochrane Library databases, and PubMed systematically. Pairwise comparisons and network meta-analyses (NMA) were conducted to analyze the effect of surgical treatments on probing depth (PD), radiographic bone fill (RBF), mucosal recession (MR), bleeding on probing (BOP), and clinical attachment level (CAL). In addition, risk of bias, quality of evidence, and statistical heterogeneity of the selected studies were evaluated. A total of 13 articles were included in this study, involving open flap debridement (OFD), resective therapy (RT), and augmentative therapy (AT) with and without adjunctive treatments (laser therapy, photodynamic therapy, local antibiotics, phosphoric acid, and ozone therapy).

Results
AT improved RBF and CAL more than OFD, but does not outperform OFD in reducing peri-implant soft-tissue inflammation. AT, OFD and RT did not significantly alter the levels of MR. Addition of ozone therapy improved the effect of AT, but addition of photodynamic therapy did not affect PD reduction and CAL gain significantly. Similarly, adjuvant treatment with phosphoric acid during RT did not significantly change the outcome of BOP.

Conclusions
Within the limitation of this systematic review and NMA, AT was superior to OFD in improving peri-implantitis outcomes. While adjunct use of ozone therapy may further improve the efficacy of AT, the limited evidence supporting this combination therapy argues for cautionary interpretation of these results.