bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in chemical characteristics and modeling sensory parameters of stored pecan nutmeats
Authors: Prabhakar Himanshu , Stoner‐Harris Taija , Adhikari Koushik , Mishra Abhinav , Bock Clive H. , Kong Fanbin 
Published: March 2023

AbstractPecan is a major specialty crop produced in the United States. Sensory evaluation and chemical analyses of pecan nutmeats are integral components of shelf life and have been employed to investigate changes during storage, but there remains a lack of knowledge regarding storage stability. Specifically, the association between shelf life and chemical characteristics has not been investigated. We aimed to investigate the chemical changes in pecan nuts during a range of storage treatments (temperature, relative humidity, packaging material, and modified atmosphere). The results of the chemical analyses were used to build a volatile compound‐based sensory prediction model. The work has utility as a rapid method to measure lipid oxidation in pecan, which is of value to the pecan industry. The research also determined a possible association between pecan nut volatile compounds and sensory attributes of pecans, and their perception by human subjects. Building a sensory‐based prediction model would reduce dependency on expensive and time‐consuming sensory methods.
Plasma acylcarnitines and gut‐derived aromatic amino acids as sex‐specific hub metabolites of the human aging metabolome
Authors: Sol Joaquim , Obis Èlia , Mota‐Martorell Natalia , Pradas Irene , Galo‐Licona Jose Daniel , Martin‐Garí Meritxell , Fernández‐Bernal Anna , Ortega‐Bravo Marta , Mayneris‐Perxachs Jordi , Borrás Consuelo , Viña José , de la Fuente Mónica , Mate Ianire , Biarnes Carles , Pedraza Salvador , Vilanova Joan C. , Brugada Ramon , Ramos Rafel , Serena Joaquin , Ramió‐Torrentà Lluís , Pineda Víctor , Daunis‐I‐Estadella Pepus , Thió‐Henestrosa Santiago , Barretina Jordi , Garre‐Olmo Josep , Portero‐Otin Manuel , Fernández‐Real José Manuel , Puig Josep , Jové Mariona , Pamplona Reinald 
Published: March 2023

AbstractAging biology entails a cell/tissue deregulated metabolism that affects all levels of biological organization. Therefore, the application of “omic” techniques that are closer to phenotype, such as metabolomics, to the study of the aging process should be a turning point in the definition of cellular processes involved. The main objective of the present study was to describe the changes in plasma metabolome associated with biological aging and the role of sex in the metabolic regulation during aging. A high‐throughput untargeted metabolomic analysis was applied in plasma samples to detect hub metabolites and biomarkers of aging incorporating a sex/gender perspective. A cohort of 1030 healthy human adults (45.9% females, and 54.1% males) from 50 to 98 years of age was used. Results were validated using two independent cohorts (1: n = 146, 53% females, 30–100 years old; 2: n = 68, 70% females, 19–107 years old). Metabolites related to lipid and aromatic amino acid (AAA) metabolisms arose as the main metabolic pathways affected by age, with a high influence of sex. Globally, we describe changes in bioenergetic pathways that point to a decrease in mitochondrial β‐oxidation and an accumulation of unsaturated fatty acids and acylcarnitines that could be responsible for the increment of oxidative damage and inflammation characteristic of this physiological process. Furthermore, we describe for the first time the importance of gut‐derived AAA catabolites in the aging process describing novel biomarkers that could contribute to better understand this physiological process but also age‐related diseases.
Feasibility of remote self‐collection of dried blood spots, hair, and nails among people with HIV with hazardous alcohol use
Authors: Firkey Madison K. , Tully Lyric K. , Bucci Veronica M. , Walsh McKenna E. , Maisto Stephen A. , Hahn Judith A. , Bendinskas Kestutis G. , Gump Brooks B. , Woolf‐King Sarah E. 
Published: March 2023

AbstractBackgroundThe use of biomarkers in behavioral HIV research can help to address limitations of self‐reported data. The COVID‐19 pandemic forced many researchers to transition from standard in‐person data collection to remote data collection. We present data on the feasibility of remote self‐collection of dried blood spots (DBS), hair, and nails for the objective assessment of alcohol use, antiretroviral therapy adherence, and stress in a sample of people with HIV (PWH) who are hazardous drinkers.MethodsStandardized operating procedures for remote self‐collection of DBS, hair, and nails were developed for an ongoing pilot study of a transdiagnostic alcohol intervention for PWH. Prior to each study appointment, participants were mailed a kit containing materials for self‐collection, instructions, a video link demonstrating the collection process, and a prepaid envelope for returning samples.ResultsA total of 133 remote study visits were completed. For DBS and nail collection at baseline, 87.5% and 83.3% of samples, respectively, were received by the research laboratory, of which 100% of samples were processed. Although hair samples were intended to be analyzed, most of the samples (77.7%) were insufficient or the scalp end of the hair was not marked. We, therefore, decided that hair collection was not feasible in the framework of this study.ConclusionAn increase in remote self‐collection of biospecimens may significantly advance the field of HIV‐related research, permitting the collection of specimens without resource‐intensive laboratory personnel and facilities. Further research is needed on the factors that impeded participants' ability to complete remote biospecimen collection.
Improving small and medium‐size enterprise performance: Does working capital management enhance the effectiveness of financial inclusion?
Authors: Bhattacharyya Asit , Rahman Md Lutfur , Wright Sue 
Published: March 2023

AbstractGrowth of the small and medium‐size enterprise (SME) sector is traditionally an important driver of overall economic growth, particularly in emerging economies. SME growth is enhanced by access to finance (financial inclusion). In this study, we show that efficient working capital management has a positive influence on performance that is independent of the effect of financial inclusion. Our results remain robust to alternative measurements and estimations, and may be useful to national policy‐makers in developing strategies for SMEs' greater access to finance and introducing ways of improving financial management education and training for SME managers.
The Dynamics of a Policy Outcome: Market Response and Bureaucratic Enforcement of a Policy Change
Authors: Callander Steven , Foarta Dana , Sugaya Takuo 
Published: March 2023

AbstractPolicy outcomes are determined not by the words in a statute but by the actions of private citizens. A policy's success or failure depends on how it shapes behavior and how that behavior shapes the future course of policy. To understand this process, we develop a model that combines the political and nonpolitical domains, focusing on competition policy and the regulation of markets. We show how the outcome of a policy change develops over time as firms respond in the market and interact with bureaucratic enforcement. We identify a critical threshold in market structure that determines whether a policy succeeds or fails, and discuss how the design of political institutions affects this level. The threshold represents a balancing of the path dependence of politics with the self‐correcting nature of markets. It establishes when political forces dominate those in markets and, thus, when a policy change has lasting effects on society.
Letter: should we abandon FIB‐4 to characterise non‐invasively patients with NAFLD?
Authors: Pugliese Nicola , Franchellucci Gianluca , Viganò Mauro 
Published: March 2023

LINKED CONTENTThis article is linked to Younossi et al papers. To view these articles, visit https://doi.org/10.1111/apt.17346 and https://doi.org/10.1111/apt.17448
Editorial: deja vu all over again – let the P‐CAB wars begin. Authors' reply
Authors: Hwang Inyoung , Lee SeungHwan 
Published: March 2023

LINKED CONTENTThis article is linked to Hwang et al papers. To view these articles, visit https://doi.org/10.1111/apt.17406 and https://doi.org/10.1111/apt.17412
“Meat and Three”: Business Ownership as an Alternative Form of Work
Authors: Rivers Dawn 
Published: March 2023

AbstractAlternatives to traditional waged and salaried work have become increasingly relevant in a post‐pandemic U.S. labor market in which it seems that everyone hates their job. This article proposes that nonemployer businesses, business firms with no paid employees other than the business owner(s), constitute a distinct economic and cultural category of independent work in the U.S. economy, in addition to being a specific category of small business. Building from anthropological scholarship on entrepreneurship and on alternative forms of work, I argue that nonemployers are a recognizably discrete group from independent contractors because they think of their ventures as businesses. At the same time, nonemployer business owners expend their energy on building more holistic lifestyles rather than on wealth and capital accumulation. These findings are based on ethnographic fieldwork conducted in New York and North Carolina from 2017 to 2020. The stories I gathered illustrate that, by doing the work and running the business, nonemployer business owners control the practices and process of their work, and avoid both the precarity of other work arrangements and the stresses of growth‐oriented entrepreneurship.
Venetoclax ramp‐up strategies for chronic lymphocytic leukaemia in the United Kingdom: a real world multicentre retrospective study
Authors: Figueroa‐Mora Rocio , Rampotas Alexandros , Halperin Daniel , Worth Tina , Vidler Jennifer , Melotti Dario , Ferguson Paul , Elmusharaf Nagah , Preston Gavin , Furtado Michelle , Dungarwalla Moez , Gohill Satyen , Patten Piers , Kennedy Ben , Eyre Toby A. , Schuh Anna , Fox Christopher P. , Munir Tahla , Martinez‐Calle Nicolas 
Published: March 2023

SummaryThis retrospective, observational study evaluated patterns of inpatient versus outpatient tumour lysis syndrome (TLS) monitoring during venetoclax ramp‐up in 170 patients with chronic lymphocytic leukaemia. The primary outcome was clinical/biochemical TLS. Two clinical and four biochemical TLS occurred (4.1%). Five of the six events occurred in high‐risk patients, four occurred at 20 mg dose and three at the 6‐h time‐point. Inpatient versus outpatient TLS rates within the high‐risk subgroup were 15% and 8%. Risk category was the only predictor of TLS events in multivariate analysis. Outpatient escalation did not associate with clinically meaningful TLS events, suggesting outpatient escalation has manageable associated TLS risks, including in high‐risk cohorts. These observations require confirmation in larger studies.
Debate: Response to “Should academics collaborate with digital companies to improve young people's mental health”
Authors: Kucirkova Natalia 
Published: March 2023

Much of the debate about academic collaboration with digital companies (see Livingstone, Orben & Odgers, 2023) has surrounded commercial use of data and children's mental health. The debate has also spilled into the educational value of technologies and academic collaboration with companies to improve their learning design. Given the close relationship between learning and mental health, the evaluation of digital companies' impact should focus on both their emotional and educational effects. The collaborative models used by educational researchers provide a source of inspiration for transparent evaluations and evidence‐based recommendations for holistic interventions that target children's learning and mental health.
Reflections on technological progress in the agri‐food industry: Past, present, and future
Authors: Hailu Getu 
Published: March 2023

AbstractTechnological advances—for example, from hand milking to robotic milking—are at the heart of economic transformation and have significantly shaped the agri‐food industry and economic growth throughout history. A look at the lead article of the first issue (and the first volume, 1952) of theCanadian Journal of Agricultural Economics(CJAE) 70 years ago reveals an ongoing inquiry within the discipline about how technological progress has shaped how we manage our farms with the implications on aggregate industry productivity and food prices. The topics discussed along these lines in the first issue of the CJAE are still relevant today—for example, challenges with measuring productivity and innovation, diffusion of innovation, technological unemployment, demand for skilled workers, financing innovations, climate change and food security. Science, technology, and innovation for the 21st century hold the potential to foster resilient and sustainable intensification of farm production and productivity growth for the agri‐food industry. In this address, I reflect on the past, present, and future impacts of technological innovations and productivity growth on the agri‐food industry and discuss the implications for future research, welfare, and policy.
Aberrant intra‐ and internetwork functional connectivity patterns of the anterior and posterior hippocampal networks in schizophrenia
Authors: Li Xin‐Wei , Liu Hong , Deng Yuan‐Yang , Li Zhang‐Yong , Jiang Yu‐Hao , Li De‐Yu , Li Shu‐Yu 
Published: March 2023

AbstractAimSchizophrenia is associated with abnormal hippocampal structure and function. Available evidence suggests that the anterior and posterior hippocampus are differentially affected by schizophrenia pathology. This study was designed to provide new insight into the anterior and posterior hippocampus in schizophrenia from the perspective of functional connectivity.MethodsBased on resting‐state functional magnetic resonance imaging data of 71 schizophrenia patients and 74 normal controls, we utilized a data‐driven approach to functionally segment the hippocampus into anterior and posterior segments and then investigated the functional connectivity patterns within and between the two hippocampal networks at the network, edge, and nodal levels.ResultsWe found that schizophrenia patients showed hyperconnectivity of both the anterior and posterior hippocampal networks. We also observed that the network alterations appear somewhat greater in the anterior hippocampal network than the posterior network, the left side than the right, and the intranetwork connectivity than the internetwork connectivity.ConclusionThe results reveal convergent and divergent intranetwork and internetwork connectivity patterns of the anterior and posterior hippocampus in schizophrenia, providing novel and important insights into the mechanisms of hippocampal pathology in schizophrenia.
Clinical and histopathologic predictors of recurrent glomerulonephritis after kidney transplantation
Authors: Chukwu Chukwuma A. , Holmberg Christopher , Storrar Joshua , Middleton Rachel , Sinha Smeeta , Kalra Phillip A. , Shawki Howida , Rao Anirudh 
Published: March 2023

AbstractIntroductionWe evaluated the long‐term outcomes of recurrent glomerulonephritis (RGN) using clinical, histopathological, and demographic predictors.MethodsA retrospective cohort study of kidney transplant recipients (KTR) in two renal centers between 2005 and 2020. Clinical and native kidney histological data were analyzed. The risk factors and outcomes of each primary glomerulonephritis subtype were assessed using Cox methods.Result336 recipients with primary glomerulonephritis were analyzed. RGN was diagnosed in 17%, 20%, 25%, and 13% of recipients with IgA nephropathy (IgAN), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN) and membranoproliferative glomerulonephritis (MPGN), respectively. Median time to recurrence was shortest in FSGS (.6 years IQR .2‐2.9) and longest in MN (6.3 years IQR 3.3‐8.0) whereas time to graft loss after diagnosis was shortest in MPGN (.3 years IQR .1‐1.7) and longest in IgAN (2.9 year IQR 1.3‐4.3). Recipients with recurrent IgAN were likely to be younger, have higher proteinuria at diagnosis, receive living donor allografts, receive cyclosporine treatment, have a history of acute rejection, and have segmental sclerosis in native glomeruli. Younger age of the donors, higher proteinuria at diagnosis, alemtuzumab, proteinuria within the first 12 months, acute rejection, low baseline eGFR, mesangial proliferation, and IgG and IgA deposits were associated with FSGS recurrence. MPGN recurrence was predicted by lower BMI at transplantation, and crescentic native disease. Death‐censored graft survival at 5‐, 10‐, and 15‐years was 83%, 51%, and 29% in the RGN group and 95%, 93%, and 84%, respectively in the non‐RGN group. Over 15 years, recipients with RGN are nine times more likely than those without RGN to lose their grafts, regardless of donor type, acute rejection, and baseline eGFR. Transplant recipients of related donor allograft were not more likely to have recurrent GN than non‐related donors.
Innovative formulae for the estimation of standard liver volume in the era of widespread imaging analysis software
Authors: Yasukawa Koya , Shimizu Akira , Ikegami Toshihiko , Mita Atsuyoshi , Ohno Yasunari , Masuda Yuichi , Soejima Yuji 
Published: March 2023

AbstractBackgroundVarious formulae have been used for the estimation of standard liver volume (SLV) in preparation for living donor liver transplantation (LDLT). However, these formulae have the disadvantage of being constructed using parameters that are substantially affected by the patient's condition. Here, we aimed to establish more precise formulae that are less affected by the general condition of the patient.MethodsWe analyzed the liver volumes of LDLT donors and patients with normal livers (total: n = 213) using the SYNAPSE VINCENT imaging analysis system, to develop new formulae. The accuracy of the new formulae were compared with those of existing formulae in a separate validation group of healthy patients (n = 200). The new formulae were also validated using 81 LDLT recipients to assess their utility for graft selection in LDLT.ResultsBody surface area (BSA) and skeletal muscle mass index (SMI) independently affected total liver volume (TLV). We produced new formulae for SLV incorporating SMI: SLV = 32.2 × L3‐SMI−466.9 for men, with R2 .92, and 25.7 × L3‐SMI−55.97 for women, with R2 .79 (alongside a BSA formula with R2 .57), which provided the most accurate predictions of TLV in the validation group. A graft volume (GV)/SLV <.35, calculated using the new formulae, predicted the postoperative prognosis, including the development of small‐for‐size syndrome, sepsis, or acute rejection, significantly more effectively than GV/SLV using the previous formulae.ConclusionsThe newly developed L3‐SMI‐based formula is more accurate for the estimation of SLV than previously reported formulae, and may thus help to improve the safety of LDLT.
Association between walking pace and incident type 2 diabetes by adiposity level: A prospective cohort study from the UK Biobank
Authors: Boonpor Jirapitcha , Parra‐Soto Solange , Gore Jasunella , Talebi Atefeh , Lynskey Nathan , Raisi Andrea , Welsh Paul , Sattar Naveed , Pell Jill P. , Gill Jason M. R. , Gray Stuart R. , Ho Frederick K. , Celis‐Morales Carlos A. 
Published: March 2023

AbstractAimsTo investigate the combined association of adiposity and walking pace with incident type 2 diabetes.MethodsWe undertook a prospective cohort study in 194 304 White‐European participants (mean age 56.5 years, 55.9% women). Participants' walking pace was self‐reported as brisk, average or slow. Adiposity measures included body mass index (BMI), waist circumference (WC) and body fat percentage (BF%). Associations were investigated using Cox proportional hazard models, with a 2‐year landmark analysis. A four‐way decomposition analysis was used for mediation and additive interaction.ResultsThe median (interquartile range) follow‐up was 5.4 (4.8‐6.3) years. During the follow‐up period, 4564 participants developed type 2 diabetes. Compared to brisk‐walking participants with normal BMI, those with obesity who walked briskly were at an approximately 10‐ to 12‐fold higher risk of type 2 diabetes (hazard ratio [HR] 9.64, 95% confidence interval [CI] 7.24‐12.84, in women; HR 11.91, 95% CI 8.80‐16.12, in men), whereas those with obesity and walked slowly had an approximately 12‐ to 15‐fold higher risk (HR 12.68, 95% CI 9.62‐16.71, in women; HR 15.41, 95% CI 11.27‐21.06, in men). There was evidence of an additive interaction between WC and BF% and walking pace among women, explaining 17.8% and 47.9% excess risk respectively. Obesity mediated the association in women and men, accounting for 60.1% and 44.9%, respectively.ConclusionsSlow walking pace is a risk factor for type 2 diabetes independent of adiposity. Promoting brisk walking as well as weight management might be an effective type 2 diabetes prevention strategy given their synergistic effects.
Remote photobiomodulation targeted at the abdomen or legs provides effective neuroprotection against parkinsonian MPTP insult
Authors: Gordon Luke C. , Martin Kristy L. , Torres Napoleon , Benabid Alim‐Louis , Mitrofanis John , Stone Jonathan , Moro Cecile , Johnstone Daniel M. 
Published: March 2023

AbstractPhotobiomodulation (PBM)—the irradiation of tissue with low‐intensity light—mitigates neuropathology in rodent models of Parkinson's disease (PD) when targeted at the head (‘transcranial PBM’). In humans, however, attenuation of light energy by the scalp and skull necessitates a different approach. We have reported that targeting PBM at the body also protects the brain by a mechanism that spreads from the irradiated tissue (‘remote PBM’), although the optimal peripheral tissue target for remote PBM is currently unclear. This study compared the neuroprotective efficacy of remote PBM targeting the abdomen or leg with transcranial PBM, in mouse and non‐human primate models of PD. In a pilot study, the neurotoxin MPTP was used to induce PD in non‐human primates; PBM (670 nm, 50 mW/cm2, 6 min/day) of the abdomen (n = 1) was associated with fewer clinical signs and more surviving midbrain dopaminergic cells relative to MPTP‐injected non‐human primates not treated with PBM. Validation studies in MPTP‐injected mice (n = 10 per group) revealed a significant rescue of midbrain dopaminergic cells in mice receiving PBM to the abdomen (~80%, p < .0001) or legs (~80%, p < .0001), with comparable rescue of axonal terminals in the striatum. Strikingly, this degree of neuroprotection was at least as, if not more, pronounced than that achieved with transcranial PBM. These findings confirm that remote PBM provides neuroprotection against MPTP‐induced destruction of the key circuitry underlying PD, with both the abdomen and legs serving as viable remote targets. This should provide the impetus for a comprehensive investigation of remote PBM‐induced neuroprotection in other models of PD and, ultimately, human patients.
Still, we rise: Lessons learned from lived experiences in the family policing system
Authors: Vega‐Brown Jeanette , Stephens Tricia N. 
Published: March 2023

AbstractThe voices of mothers affected by the child welfare system are forefronted in this article. A group of five women, all affiliated with the parent‐led, community‐based organization Rise Magazine, gathered to discuss their experiences, including any role they believed race, racism and other forms of bias played in their child welfare cases. Their powerful, first‐hand accounts illustrate the systemic injustices faced by child welfare affected families. This article also focuses on the development of Rise's organizational structure as a space where parents both lead and drive the organization's mission to empower and support system affected families. A postscript by Tricia Stephens, integrating how parents’ experiences are reflected in existing research, is provided. It is the hope of the parents who currently work at and those who have passed through Rise, that sharing their personal stories inspires and helps to guide others across the country.