bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myofascial release as neuromotor support to improve the ineffective sucking ability in infants.
Authors: Arcusio Andrea , Villa Maria Cristina , Felloni Federica , Migliori Claudio 
Published: April 2023

Abstract
Background Breastfeeding plays a primary role in the events that characterize the development of the relationship between a mother and her newborn. However, this essential process sometimes does not fully cover the nutritional requirements of the newborn due to altered biomechanical sucking skills. In this context, adequate osteopathic treatment associated with neuromotor facilitation techniques could play a promoting role.Methods This study evaluated the effect of the osteopathic approach using myofascial release on 26 infants with ineffective sucking ability, identified by the POFRAS scale and LATCH score, compared with 26 untreated similar infants. After the procedure was initially performed in the hospital, the strategy based on basic neuromotor patterns was taught to the parents to be continued at home. The effects were measured at hospital discharge, during the first outpatient visit, which occurred after about seven days, and at one month of life.Results The number of valid and continuous suctions, initially less than five per feed in both groups, at the first outpatient check-up was significantly higher (p < 0.00001) in the treated group. Exclusive breastfeeding, initially present in all enrolled children, was maintained mainly in treated children, both at discharge (p < 0.003), at outpatient follow-up (p < 0.00001), and at one month of life (p < 0.00001). Differences in growth and health conditions were not found between the groups.Conclusion We believe that osteopathic treatment associated with neuromotor facilitation techniques can optimize newborns' sucking skills, improving the acquisition and duration of breastfeeding.
First reported case of Peptostreptococcus stomatis bacteremia in left orbit apex syndrome patient after dental repair
Authors: Wang Qihui , Li Fushun , Chen Jingjing , Zhang Han , Zhang Jingping , Nian Hua 
Published: April 2023

Abstract
Orbital apex syndrome is a life-threatening disease that is very rarely caused by anaerobic bacterial infections. In particular, Peptostreptococcus stomatis, a newly discovered species of Peptostreptococcus species, which is commonly thought to be associated with the development of colorectal cancer (CRC) in patients and oral squamous cell carcinoma (OSCC). However, there is no report that other site infections and bacteremia was caused by this organism. We firstly herein report a case of P.stomatis bacteremia in a 63-year-old woman who was diagnosed with left orbital apex syndrome and cellulitis of both eyelids originated from a dental reparation. This report illustrates the importance of using traditional methods and experience for identification when MALDI-TOF MS failed, which still facilitates the timely selection of appropriate antibiotics for treatment, thus achieving a favorable outcome.
Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based high-throughput platform
Authors: Giguere Patrick , Zeghal Manel , Laroche Geneviève , Freitas Julia Douglas , Wang Rebecca 
Published: April 2023

Abstract
Representing the most attractive and successful druggable receptors of the proteome, GPCRs regulate a myriad of physiological and pathophysiological functions. Although over half of present pharmaceuticals target GPCRs, the advancement of drug discovery is hampered by a lack of adequate screening tools, the majority of which are limited to probing agonist-induced G-protein and β-arrestin-2-mediated events as a measure of receptor activation. Here, we develop Tango-Trio, a comprehensive cell-based high-throughput platform capable of the parallelized profiling of both basal and agonist-dependent GPCR activities. We capture the functional diversity of GPCRs, reporting β-arrestin-1/2 couplings, selectivities, and receptor internalization signatures across the GPCRome. Moreover, we present the first construction of dose-dependent basal activation curves at approximately 200 receptors, including over 50 orphans. Overall, Tango-Trio’s robustness is well-suited for the functional characterization and screening of GPCRs, especially for parallel interrogation, and is a valuable addition to the pharmacological toolbox.
The oral health of secondary school pupils: baseline data from the Brushing RemInder 4 Good oral HealTh (BRIGHT) trial
Authors: Innes Nicola , Marshman Zoe , Fairhurst Caroline , Elyousfi Sarab , Whiteside Katie , Ainsworth Hannah , Chestnutt Ivor , Day Peter , Dey Donna , Hewitt Catherine , Hicks Kate , Sykes Debbie , Pavitt Sue , Robertson Mark , Robison-Smith Lynn , Torgerson David , Turner Emma 
Published: April 2023

Abstract
Background
This paper describes the socio-demographics and oral health of secondary school pupils. They were participants of the BRIGHT trial, which was designed to evaluate the effectiveness of a toothbrushing intervention to reduce dental caries.
Methods
Overall, 4680 pupils aged 11-13 years attending 42 secondary schools in England, Scotland, and Wales with above average proportion of pupils eligible for free school meals were recruited to the trial. Socio-demographic data were collected. Participants had a clinical assessment for caries, plaque and bleeding and completed measures of oral and general health-related quality of life and oral health behaviours (frequency of toothbrushing, dental attendance and cariogenic food/drinks consumed). Regression analyses were performed.
Results
Over one-third (34.7%) of participants had caries experience with 44.5% reporting their oral health had an impact on their daily lives. Factors associated with a statistically significant increased likelihood of caries experience were older age, females, eligibility for free school meals, worse oral health-related quality of life, higher cariogenic intake, less than twice-daily toothbrushing, living in a more deprived area and lower school attendance.
Conclusions
The prevalence and impact of dental caries on the lives of pupils remains high with further oral health promotion activities needed in targeted secondary schools.
Trial registration: ISRCTN12139369.
COVID-19 and Diagnosis Related Group In An Asian Middle-Income Country: Patient classifications and associated hospital costs
Authors: Azzeri Amirah , Yasim Mohamad Helmi Mohamad , Nizamuddin Muhammad Khairul Asraf Shah , Yahya Mohmmad Salleh , Dahlui Maznah , Samsudin Nadia , Jaafar Mohd Hafiz , Omar Sharifah Faridah Syed , Kamarulzaman Adeeba , Hasnan Nazirah , Bulgiba Awang 
Published: April 2023

Abstract
Background The COVID-19 pandemic impacted healthcare systems in many aspects, with the most immediate need being the increased healthcare burden and healthcare costs. This study aimed to determine the distribution of the disease and its costs of COVID-19 management in Malaysia.Methods Data on hospital admissions related to COVID-19 were coded with ICD-10 and ICD9-CM, and the combination generated DRG codes, which were A-4-13-I, A-4-13-II and A-4-13-III for mild, moderate and severe classification of COVID-19 respectively. Simultaneously, healthcare resource utilisation and costs were estimated for the codes through clinical pathways. The distribution of COVID-19 patients based on DRG was presented as frequencies and percentages while cost data were reported in US$ with the price year 2021.Results A total of 4889 patients with COVID-19 diagnosis were admitted to the hospital. Of that, 4813/4889(98%) had a primary diagnosis of COVID-19 while the remaining patients were admitted for other medical reasons, however, were found to be positive during the admission. 3909(81%) were admitted with mild COVID-19 (A-4-13-I), 630(13%) had moderate COVID-19 (A-4-13-II) and 274(6%) were admitted for severe COVID-19 (A-4-13-III). The cumulative hospital costs for mild COVID-19 (A-4-13-I) were estimated to be USD 1,543. While the cumulative hospital costs for both moderate COVID-19 (A-4-13-II) and severe COVID-19 (A-4-13-III) were estimated at USD 23,527 and USD 26,731 respectively.Conclusions The total costs incurred by the hospital for COVID-19 were estimated to be USD 19,259,153. COVID-19 resulted in significant economic implications for the healthcare system. This study provides local data and an assessment of the economic burden of Covid-19 infection in Malaysia.
“I’d like more options!”: Interviews to explore young people and family decision-making needs for pain management in juvenile idiopathic arthritis
Authors: April Karine Toupin , Gaboury Isabelle , Proulx Laurie , Huber Adam M , Duffy Ciarán M , Morgan Esi M , Li Linda C , Stringer Elizabeth , Connelly Mark , Weiss Jennifer E , Gibbon Michele , Sachs Hannah , Sivakumar Aditi , Sirois Alexandra , Sirotich Emily , Trehan Natasha , Abrahams Naomi , Cohen Janice S , Cavallo Sabrina , Hindi Tania El , Ragusa Marco , Légaré France , Brinkman William B , Fortin Paul R , Décary Simon , Lee Rebecca , Gmuca Sabrina , Paterson Gail , Tugwell Peter , Stinson Jennifer 
Published: April 2023

Abstract
Background Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic condition and is associated with symptoms such as joint pain that can negatively impact health-related quality of life. To effectively manage pain in JIA, young people, their families, and health care providers (HCPs) should be supported to discuss pain management options and make a shared decision. However, pain is often under-recognized, and pain management discussions are not optimal. No studies have explored decision-making needs for pain management in JIA using a shared decision making model. We sought to explore families’ decision-making needs with respect to pain management among young people with JIA, parents/caregivers, and HCPs.Methods We conducted semi-structured virtual or face-to-face individual interviews with young people with JIA 8–18 years of age, parents/caregivers and HCPs using a qualitative descriptive study design. We recruited participants online across Canada and the United States, from a hospital and from a quality improvement network. We used interview guides based on the Ottawa Decision Support Framework to assess decision-making needs. We audiotaped, transcribed verbatim and analyzed interviews using thematic analysis.Results A total of 12 young people (n = 6 children and n = 6 adolescents), 13 parents/caregivers and 11 HCPs participated in interviews. Pediatric HCPs were comprised of rheumatologists (n = 4), physical therapists (n = 3), rheumatology nurses (n = 2) and occupational therapists (n = 2). The following themes were identified: (1) need to assess pain in an accurate manner; (2) need to address pain in pediatric rheumatology consultations; (3) need for information on pain management options, especially nonpharmacological approaches; (4) importance of effectiveness, safety and ease of use of treatments; (5) need to discuss young people/families’ values and preferences for pain management options; and the (6) need for decision support. Themes were similar for young people, parents/caregivers and HCPs, although their respective importance varied.Conclusions Findings suggest a need for evidence-based information and communication about pain management options, which would be addressed by decision support interventions and HCP training in pain and shared decision making (SDM). Work is underway to develop such interventions and implement them into practice to improve pain management in JIA and in turn lead to better health outcomes.
Diabetes Care Cascade and Compliance with WHO Global Coverage Targets in Iran: Findings of STEPS Survey 2021
Authors: Azadnajafabad Sina , Ahmadi Naser , Rezaei Negar , Rashidi Mohammad-Mahdi , Moghaddam Sahar Saeedi , Mohammadi Esmaeil , Abbasi-Kangevari Mohsen , Naderian Mohammadreza , Ghasemi Erfan , Farzi Yosef , Kazemi Ameneh , Dilmaghani-Marand Arezou , Yoosefi Moein , Rezaei Shahabeddin , Nasserinejad Maryam , Fattahi Nima , Rezaei Nazila , Haghshenas Rosa , Mehr Elmira Foroutan , Koolaji Sogol , Razi Farideh , Djalalinia Shirin , Larijani Bagher , Farzadfar Farshad 
Published: April 2023

Abstract
This study aimed to investigate the diabetes mellitus (DM) and prediabetes epidemiology, care cascade, and compliance with global coverage targets. We recruited the results of the nationally representative Iran STEPS Survey 2021. Diabetes and prediabetes were two main outcomes. Diabetes awareness, treatment coverage, and glycemic control were calculated for all population with diabetes to investigate the care cascade. Four global coverage targets for diabetes developed by the World Health Organization were adopted to assess the DM diagnosis and control status. Among 18 119 participants, the national prevalence of DM and prediabetes were 14.2% (95% confidence interval: 13.4–14.9) and 24.8% (23.9–25.7), respectively. The prevalence of DM treatment coverage was 65.0% (62.4–67.7), while the prevalence of good (HbA1C < 7%) glycemic control was 28.0% (25.0–31.0) among all individuals with diabetes. DM diagnosis and statin use statics were close to global targets (73.3% vs 80%, and 50.1% vs 60%); however, good glycemic control and strict blood pressure control statistics, were much way behind the goals (36.7% vs 80%, and 28.5% vs 80%). A major proportion of the Iranian population are affected by DM and prediabetes, and glycemic control is poorly achieved, indicating a sub-optimal care for diabetes and comorbidities like hypertension.
Comprehensive Analysis and Evaluation of the Geometric Errors of the Rotating Axis of Five-axis Double-pendulum Machine Tools Based on S-shaped Samples.
Authors: Wu Shi , Yuan Chunqiang , Yu Tai , Wang Yupeng , Zhang Yong 
Published: April 2023

Abstract
The geometric error of the rotation axis of a multi-axis machine tool is a highly sensitive error in the geometry error of the machine tool. Therefore, establishing an evaluation system for geometric errors of rotation axes is important for improving the machining accuracy of workpieces. First, a model for predicting the geometric error of the rotation axis was established based on the multi-body system theory, and then the mapping relationship between the geometric error of the rotation axis and each region with curvature changes in the S-shaped sample is identified. Next, based on the average value in seven different regions with curvature changes in the S-shaped sample, the weights of the mapping regions were calculated. Subsequently, the weights of the 12 geometric errors of the rotation axis (εx (A), εy (A), εz (A), (δx (A), (δy(A), (δz(A), (εx (C), εy (C), εz (C), (δx (C), (δy(C) and (δz(C)), and the weights of two rotation axes were identified to establish a comprehensive evaluation system for the geometric errors of rotation axes. Finally, an S-shaped sample was machined on the TuopuVMC-C50 five-axis CNC machine tool, and on-machine measurement experiments were conducted on two rotation axes with the established evaluation system. The results indicate that the relative error between the actual value and the theoretical value is less than 1.0%. Further, the comprehensive performance of the machine's rotation axes was evaluated step by step based on the theoretically calculated weight values.
Changes in land cover and atmospheric circulation are reducing rainfall in the Brazilian Cerrado
Authors: Hofmann Gabriel S. , Silva Rafael C. , Weber Eliseu J. , Barbosa Alexandre A. , Oliveira Luiz F. B. , Alves Ruy J. V. , Hasenack Heinrich , Schossler Venisse , Aquino Francisco E. , Cardoso Manoel F. 
Published: April 2023

Abstract
Here we analyze the trends of rainfall and the frequency of rainy days over the Brazilian Cerrado between 1960 and 2021 in four distinct periods according to the seasonal patterns over the region. We also evaluated trends in evapotranspiration, winds, and atmospheric humidity over the Cerrado to elucidate the possible reasons for the detected trends. We recorded a significant reduction in rainfall and frequency of rainy days in the northern and central Cerrado regions for all periods except at the beginning of the dry season. These findings are associated with the intensification of the South Atlantic High, which has been shifting atmospheric circulation and raising regional subsidence. Moreover, during the dry season and the beginning of the wet season, there was a reduction in regional evapotranspiration, which also potentially contributed to the rainfall reduction. Our results suggest broad environmental and social impacts that transcend the Cerrado boundaries.
Effects of maternal stress induced by predator cues on spatial learning and memory of offspring in the subterranean rodent Ctenomys talarum
Authors: Iribarne J , Bracchetta V ; , Kittlein M , Schleich C , Zenuto R 
Published: April 2023

AbstractOne of the main selection pressures to which animals are exposed in nature is predation, which affects a wide variety of biological traits. When the mother experiences this stressor during pregnancy and/or lactation, behavioral and physiological responses may be triggered in the offspring as well. Thus, in order to broaden and deepen knowledge on the transgenerational effects of predation stress, we evaluated how maternal stress experienced during pregnancy and/or lactation affects the spatial abilities of progeny at the onset of adulthood in the subterranean rodentCtenomys talarum. The results showed that, contrary to what was observed in other rodent species, maternal exposition to predator cues during pregnancy and lactation did not negatively affect the spatial abilities of the offspring, even registering some minor positive effects. Concomitantly, no effects of predatory cues on physiological parameters associated with stress were observed in the progeny. This difference in results between the present study and previous works on maternal stress highlights the importance of considering the species to be evaluated (strain, age and origin -wild or captive-) and the type of stressor used (artificial or natural, intensity of exposure) in the evaluation of the possible transgenerational effects of maternal stress.
Hand Injuries Requiring Surgical Intervention During the FIFA World Cup Qatar 2022; A Retrospective Epidemiological Study
Authors: Omari Rand Y. , Salman Loay A. , Aljassem Ghanem , Misk Rami A. , Al-Omari Ahmad Y. , Muneer Mohammed , Allahham Salim 
Published: April 2023

Abstract
Introduction:
Major sporting events worldwide are generally associated with higher incidence of violence from fans and visitors around the world, leading to higher number of injuries. The FIFA World Cup 2022 took place in Doha, Qatar from November 20th to December 18th, 2022. The aim of this study is to focus on the number of hand injuries during that time which required surgical intervention, and to provide a clinical description of these hand injuries.
Material and Methods:
Records of 103 patients with hand injuries were reviewed during the period of the FIFA World Cup 2022. The statistical software (IBM SPSS version 24; SPSS Inc., Chicago, IL, USA) was used for data analysis. Measures of variation and central tendency were used to summarize the patients’ main characteristics and epidemiological profile.
Results:
The mean age of the patients was 33.4 ± 11.7 years. The vast majority of patients were residents of Qatar (95%), while visitors accounted for only 5% of cases. The most common mechanism of injury was cutting penetrating (43%). Work-related injuries accounted for the majority of cases (55%).
Conclusion:
Our results indicated no significant increase in workflow during the month of the tournament, which the authors attribute to the high level of coordination between the organizing bodies. However, we recommend all hospitals in countries hosting such tournaments to be prepared for major incidents through logistical preparations, educational courses, and back-up plans of the surgeons on-call schedules to ensure smooth flow, patient safety and avoid staff fatigue.
Features of the Conversion of Ethylene in Air and Argon in a Barrier Discharge: Experiment and Modeling
Authors: Ryabov A. Yu. , Kudryashov S. V. 
Published: April 2023

Abstract
The oxidative and non-oxidative conversion of ethylene in a barrier discharge in the presence of water is studied. The use of a plasma-chemical reactor with a water film flowing down its walls allows efficient quenching of the formed reaction products, excluding their re-exposure to the discharge plasma. Oxidation of ethylene with air results in the formation of both oxygen-containing substances and gaseous hydrocarbons with a predominant content of acetylene. Saturated and unsaturated С1‒С5+ hydrocarbons with a predominance of compounds with four carbon atoms in the molecule are resulted from non-oxidative conversion of ethylene in an argon atmosphere. The level of ethylene conversion per pass of the reaction mixture through the plasma-chemical reactor is 12.8 and 58.9 wt% for oxidizing and non-oxidizing conditions, respectively. The efficiency of the reaction of ethylene dimerization into unsaturated hydrocarbon gases is shown in comparison with the reaction of its air oxidation into oxygenates. The results of theoretical calculations of electron energy losses in a barrier discharge for the case of air oxidation of ethylene reveal the preferential excitation of various states of nitrogen molecules. In the case of ethylene dimerization in argon, the number of excited ethylene molecules at the electronic levels increases, resulting in an increase of its conversion. A model of the chemical kinetics of ethylene conversion in a barrier discharge has been developed that includes more than 280 reactions. A good agreement between the calculated and experimental data has been obtained. New fundamental knowledge about the processes of decomposition of the ethylene molecule under the effect of electrons of a barrier discharge with an average energy of 4–5 eV have been gained through the experimentation with models.
Feasibility of Orbital Friction Stir Welding on Clad Pipes of Api X65 Psl 2 Steel and Inconel 625
Authors: Amavisca C. V. , Bergmann L. , Lessa C. R L. , Schroeder J. G. , Ramos F. D. , Lemos G. V. B. , Reguly A. , Klusemann B. 
Published: April 2023

Abstract
In this work, orbital friction stir welding (Orbital FSW) has been now developed in clad pipes, which is certainly of interest to the oil and gas industry. In this context, a system capable of performing sound joints in one pass with full tool penetration was developed. Therefore, orbital FSW was executed in clad pipes of 6 mm thick API X65 PSL2 steel and a 3 mm thick Inconel 625 with a polycrystalline cubic boron nitride (pcBN) tool. Furthermore, the metallurgical properties of the welded joints were investigated and discussed. Sound joints with axial forces of 45–50 kN, rotational speed of 400–500 rpm and welding speed of 2 mm/s were obtained, proving that the developed system can perform joints by orbital FSW without volumetric defects.
Sterically crowded thioamides: Deviations from planarity as determined by X- ray structure analyses and quantum chemical calculations
Authors: Voss Jürgen , Buddensiek Dirk 
Published: April 2023

Abstract
The structures of selected thiobenzamides and some corresponding benzamides with two more or less bulky N-substituents have been studied by single-crystal X-ray diffraction analyses. The planarity of the thioamide moiety, i.e. the internal rotation about the Ar-CS and the C-N bond as well as the bending of the two N-substituents versus the thioamide plane, was determined from the data. The experimental data were corroborated by quantum chemical calculations of molecular ensembles in the crystal and, in particular, by Hirshfeld surface analysis.