bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Contraction Mode in Determining Exercise Tolerance, Torque–Duration Relationship, and Neuromuscular Fatigue
Authors: DUCROCQ GUILLAUME P. , AL ASSAD SIMON H. , KOUZKOUZ NABIL , HUREAU THOMAS J. 
Published: March 2023

ABSTRACT

Purpose
Critical torque (CT) and work done above it (W′) are key predictors of exercise performance associated with neuromuscular fatigue. The aim of the present study was to understand the role of the metabolic cost of exercise in determining exercise tolerance, CT and W′, and the mechanisms of neuromuscular fatigue.

Methods
Twelve subjects performed four knee extension time trials (6, 8, 10, and 12 min) using eccentric, isometric, or concentric contractions (3-s on/2-s off at 90°·s−1 or 30°·s−1) to modulate the metabolic cost of exercise. Exercise performance was quantified by total impulse and mean torque. Critical torque and W′ were determined using the linear relationship between total impulse and contraction time. Cardiometabolic, neuromuscular, and ventilatory responses were quantified. Neuromuscular function was evaluated by maximal voluntary contraction, resting potentiated single/doublet electrical stimulations, and superimposed single electrical stimulation to quantify neuromuscular, peripheral, and central fatigue, respectively.

Results
Compared with isometric exercise, total impulse (+36% ± 21%; P < 0.001), CT (+27% ± 30%; P < 0.001), and W′ (+67% ± 99%; P < 0.001) were increased during eccentric exercise, whereas total impulse (−25% ± 7%; P < 0.001), critical torque (−26% ± 15%; P < 0.001), and W′ (−18% ± 19%; P < 0.001) were reduced in concentric exercise. Conversely, the metabolic response and the degree of peripheral fatigue were reduced during eccentric exercise, whereas they were increased during concentric exercise. Critical torque was negatively associated with oxygen consumption gain (R
2 = 0.636; P < 0.001), and W′ was negatively associated with rates of neuromuscular and peripheral fatigue indices (R
2 = 0.252–0.880; P < 0.001).

Conclusions
The contraction mode influenced both CT and W′, and consequently exercise tolerance, indicating that the metabolic cost of contraction played a key role.
A model incorporating histopathology and preoperative gadoxetic acid-enhanced MRI to predict early recurrence of hepatocellular carcinoma without microvascular invasion after curative hepatectomy
Authors: Qu Qi , Lu Mengtian , Xu Lei , Zhang Jiyun , Liu Maotong , Jiang Jifeng , Zhao Xiance , Zhang Xueqin , Zhang Tao 
Published: March 2023

Objectives: To assess the predictive value of preoperative gadoxetic acid (GA)-enhanced magnetic resonance imaging (MRI) features and postoperative histopathological grading for early recurrence of hepatocellular carcinoma (HCC) without microvascular invasion (MVI) after curative hepatectomy. Methods: A total of 85 MVI-negative HCC cases were retrospectively analyzed. Cox analyses were used to identify the independent predictors of early recurrence (within a 24 months span). The clinical prediction Model-1 or Model-2 was established without or with postoperative pathological factor, respectively. Nomogram models were constructed and receiver operating characteristic (ROC) curve analysis was used to assess the models’ predictive ability. Internal validation of the prediction models for early HCC recurrence was performed using a bootstrap re-sampling approach. Results: In the multivariate cox regression analysis, Edmondson-Steiner grade, peritumoral hypointensity on hepatobiliary phase (HBP), and relative intensity ratio (RIR) in HBP were identified as independent variables associated with early recurrence. The C-index of the nomogram models and internal validation were both between 0.7 and 0.8, showing good model fitting and calibration effects. The area under the ROC curve (AUC) was 0.781 for Model-1 based on the two preoperative MRI factors. When a third factor, the Edmondson-Steiner grade, was included (Model-2), the AUC increased to 0.834, and the sensitivity increased from 71.4 to 96.4%. Conclusions: Edmondson-Steiner grade, peritumoral hypointensity on HBP, and RIR on HBP can help predict early recurrence of MVI-negative HCC. In comparison with Model-1 (only imaging features), Model-2 (imaging features + histopathological grades) increases the sensitivity in predicting early recurrence of HCC without MVI. Advances in knowledge: Preoperative GA-enhanced MRI signs are of great value in predicting early postoperative recurrence of HCC without MVI, and a combined pathological model was established to evaluate the feasibility and effectiveness of this technique.
Predicting Bond Return Predictability
Authors: Borup Daniel , Eriksen Jonas N. , Kjær Mads M. , Thyrsgaard Martin 
Published: March 2023

This paper provides empirical evidence on predictable time variations in out-of-sample bond return predictability. Bond return predictability is associated with periods of high (low) economic activity (uncertainty), which implies that violations of the expectations hypothesis are state dependent and linked to features of the business cycle. These state dependencies in predictability, established by introducing a new multivariate test for equal conditional predictive ability, can be used in real time to improve out-of-sample bond risk premia estimates and investors’ economic utility through a novel dynamic forecast combination scheme that uses predicted forecasting performance to identify the best set of methods to include in the combined forecast. Dynamically combined forecasts exhibit strong countercyclical behavior and peak during recessions.This paper was accepted by Lukas Schmid, finance.Funding: This work was supported by the Danish Council of Independent Research [Grants DFF 7024–00020B and DFF 9033–00003B] and the Danish Finance Institute.Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2023.4713 .
Intertemporal Price Discrimination via Randomized Promotions
Authors: Chen Hongqiao , Hu Ming , Wu Jiahua 
Published: March 2023

Problem definition: The undesirable but inevitable consequence of running promotions is that consumers can be trained to time their purchases strategically. In this paper, we study randomized promotions, where the firm randomly offers discounts over time, as an alternative strategy of intertemporal price discrimination. Methodology/results: We consider a base model where a monopolist sells a single product to a market with a constant stream of two market segments. The segments are heterogeneous in both their product valuations and patience levels. The firm precommits to a price distribution, and in each period, a price is randomly drawn from the committed distribution. We characterize the optimal price distribution as a randomized promotion policy and show that it serves as an intertemporal price discrimination mechanism such that high-valuation customers would make a purchase immediately at a regular price upon arrival, and low-valuation customers would wait for a random promotion. Compared against the optimal cyclic pricing policy, which is optimal within the strategy space of all deterministic pricing policies, the optimal randomized pricing policy beats it if low-valuation customers are sufficiently patient and the absolute discrepancy between high and low customer valuations is large enough. We extend the model in three directions. First, we consider the case where a portion of customers are myopic and would never wait. We show that the existence of myopic customers is detrimental to the firm’s profitability, and the expected profit from an optimal randomized pricing policy decreases as the proportion of myopic customers in the population increases. Second, we consider Markovian pricing policies where prices are allowed to be intertemporally correlated in a Markovian fashion. This additional maneuver allows the firm to reap an even higher profit when low-valuation customers are sufficiently patient by avoiding consecutive promotions but, on average, running the promotion more frequently with a smaller discount size. Lastly, we consider a model with multiple customer segments and show that a two-point price distribution remains optimal, and our conclusion from the two-segment base model still holds under certain conditions that are adopted in the literature. Managerial implications: Our results imply that the firm may want to deliberately randomize promotions in the presence of forward-looking customers. Funding: This work was supported by the National Natural Science Foundation of China [Grant 72201124], the Natural Sciences and Engineering Research Council of Canada [Grants RGPIN-2015-06757 and RGPIN-2021-04295], and the Youth Project of the Humanities and Social Science Foundation of the Ministry of Education of China [Grant 22YJC630006]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.1194 .
Are "Modal Adverbs" automatically Modal Markers? The Case of French "Certainement" with its Epistemico-Modal and its Evidential Use
Authors: Dendale Patrick 
Published: March 2023

The French adverb certainement (‘certainly’) is labelled a “modal adverb”. It has two (sentence adverb) uses according to the literature, called “strong modal use” and “weak modal use”. The strong modal use is indeed strong (epistemico-)modal in that it indicates total certainty, whether subjective or intersubjective. What is called its “weak modal use” is shown to be an evidential use. It indicates primarily that the content qualified by the adverb results from a non-monotonic inference, performed by the speaker, whose conclusions are plausible, defeasible, and thus never totally certain. This is due to the presence of an evidential-inferential component in its meaning. As for the so-called weak modal element of “probability” in its meaning, we reanalyse it as “non- certainty” and argue it is an element of utterance meaning, a property of quasi-assertions to which non-monotonically inferred content gives rise. Finally, we claim that the adverb also has a meaning component that we call “epistemic posture of certainty”, shown to be different from epistemic modality. On the basis of three parameters and their values, we show how certainementcan be interpreted, in a series of contextual configurations, either as an instance of its epistemico- modal use or of its evidential use.
Evidentiality in Spoken Catalan. The Evidential Marker "diu que"
Authors: Antolí Martínez Jordi M. , Sentí i Pons Andreu 
Published: March 2023

This study deals with an Catalan evidential marker without a written tradition, but mainly an oral one: diu que (‘(s)he.says.that’, ‘it is said that’), a Romance correlate for dizque (Spanish) or dice che (Italian) (cf. Travis 2006, Cruschina 2015, Alcázar 2018). The spoken, dialectal and, to some extent, residual nature of this marker forces us to search for different sources in order to approach it. The study focuses on the oral recordings of Museu de la Paraula [Word Museum] —an ethnological archive with monological spoken texts— will be completed with the examination of the first results of the colloquial corpus Parlars —a dialectal and informal corpus with monological and dialogical spoken texts. The analysis of diu que and the corpus data show a partially grammaticalized construction with a reportative evidential value. A mirative extension can be also found, but not a pure epistemic meaning. Also, the rise of diu que has been seen as an example of grammatical constructionalization with a tendency towards more subjective meanings, from a quotative strategy to a reportative evidential marker. Related markers such asque diu que or the conventional formula to begin tales això diu que era have been attested.
Aspectos cognitivos y construcciones de la evolución semántica del verbo "tocar"
Authors: Fernández Jaén Jorge 
Published: March 2023

Este artículo presenta un análisis diacrónico del verbo tocar realizado desde los parámetros de la semántica cognitiva diacrónica, tal y como los expone Geeraerts (1997). Demostraremos que la intrincada polisemia que tocar muestra en la actualidad es el resultado de la expansión semasiológica del verbo a lo largo de los siglos, expansión que se origina en el primer significado prototípico del verbo (GOLPEAR) y que se desarrolla a partir de diversas reformulaciones en sus esquemas de imagen, de múltiples proyecciones metafóricas y metonímicas y de la actuación de la dinámica de fuerzas (Talmy 1988, 2000). Asimismo, probaremos que la motivación de todo el desarrollo diacrónico de tocar está regulada por la conciencia corporal del hablante (de acuerdo con lo que predice el principio cognitivo de indexicalidad) y que las construcciones sintácticas del verbo reproducen icónicamente dicha conciencia corporal.
Application of acquiring region of interest based on the YOLOv5 model in terahertz digital holography
Authors: Cheng Keyang , Li Qi 
Published: March 2023

The imaging process of terahertz in-line digital holography is susceptible to environmental interference, and it is difficult to obtain high-quality images and image segmentation results. The challenge can be better handled by using the region of interest (ROI) condition to improve the image quality of the object region and reduce the interference of peripheral noise. In this paper, for two-dimensional 2.52 THz in-line digital holography, a method to add a variety of real backgrounds in the simulation scene is proposed, and through this method, a sufficient amount of close-to-real-scene images are produced to train the YOLOv5 model. The object ROI is extracted by the YOLOv5 model (YOLOv5-ROI). Based on the region, a new, to the best of our knowledge, support-domain-constrained phase retrieval algorithm (YOLOv5-ROI-SPRA) and an image segmentation method combined with the Otsu method (YOLOv5-ROI-Otsu) are proposed, respectively. The better results show that the expected purpose is achieved.
Latin America Optics and Photonics 2022: introduction to the feature issue
Authors: Gomes Anderson S. L. , de Souza Eunezio Thoroh , Zezell Denise M. 
Published: March 2023

The 2022 Latin America Optics and Photonics Conference (LAOP 2022), the major international conference sponsored by Optica in Latin America, returned to Recife, Pernambuco, Brazil, after its first edition in 2010. Held every two years since (except for 2020), LAOP has the explicit objective to promote Latin American excellence in optics and photonics research and support the regional community. In the 6th edition in 2022, it featured a comprehensive technical program with recognized experts in fields critical to Latin America, highly multidisciplinary, with themes from biophotonics to 2D materials. The 191 attendees of LAOP 2022 listened to five plenary speakers, 28 keynotes, 24 invited talks, and 128 presentations, including oral and posters.
Real-time validation of downstream 50G/25G and 50G/100G flexible rate PON based on Miller encoding, NRZ, and PAM4 modulation
Authors: van Veen Doutje , Houtsma Vincent 
Published: March 2023

Experimental demonstration is given of a real-time flexible downstream 50 Gb/s passive optical network (PON) mixed with 25 Gb/s or 100 Gb/s signals. 25 Gb/s transmission is enabled by using 25 Gb/s Miller encoding. For back-to-back a lower sensitivity for 25 Gb/s Miller of ∼2.2dB is found relative to 50 Gb/s non-return-to-zero (NRZ). An extended reach of 40 km and up to ∼5dB optical power budget improvement after worst-case 20 km standard single-mode fiber over 50 Gb/s NRZ was shown for 25 Gb/s Miller. It was also shown that optical network units (ONUs) that have 9 dB additional optical received power because they experience a lower optical loss can receive 100 Gb/s four-level pulse amplitude modulation (PAM4) instead of NRZ in a flexible rate PON, which will double the bit-rate to these ONUs. 50 Gb/s NRZ transmission under mixed modulation (50% NRZ and 50% Miller or 50% PAM4) can operate with very low penalty. A power penalty of <0.4dB was found for 50 Gb/s NRZ after worst-case total dispersion (as specified in ITU-T G.9804) when mixed with 25 Gb/s Miller or 100 Gb/s PAM4. For back-to-back there was a smaller penalty of <0.2dB for 50 Gb/s NRZ under mixed modulation. The 25 Gb/s Miller signal spectrum is similar to 50 Gb/s NRZ and 100 Gb/s PAM4, which enables good performance of the real-time clock and data recovery with an integrated adaptive feed-forward-equalizer based equalizer under mixed signal modulation. The increased optical power budget enabled by the 25 Gb/s Miller encoding effectively improves power margins of the high-speed PON and will enable reliable transmission for ONUs deployed with out-of-spec (higher) loss and/or (larger) fiber reach. The additional margin provided by 25 Gb/s Miller encoding will also enable a safe-mode for ONUs that experience out-of-spec scenarios because of faults in the PON fiber network.
Numerical analysis of the ultra-wide tunability of nanofiber Bragg cavities
Authors: Takashima Hideaki , Schell Andreas W. , Takeuchi Shigeki 
Published: March 2023

Nanofiber Bragg cavities (NFBCs) are solid-state microcavities fabricated in optical tapered fiber. They can be tuned to a resonance wavelength of more than 20 nm by applying mechanical tension. This property is important for matching the resonance wavelength of an NFBC with the emission wavelength of single-photon emitters. However, the mechanism of the ultra-wide tunability and the limitation of the tuning range have not yet been clarified. It is important to comprehensively analyze both the deformation of the cavity structure in an NFBC and the change in the optical properties due to the deformation. Here, we present an analysis of the ultra-wide tunability of an NFBC and the limitation of the tuning range using three dimensional (3D) finite element method (FEM) and 3D finite-difference time-domain (FDTD) optical simulations. When we applied a tensile force of 200 μN to the NFBC, a stress of 5.18 GPa was concentrated at the groove in the grating. The grating period was extended from 300 to 313.2 nm, while the diameter slightly shrank from 300 to 297.1 nm in the direction of the grooves and from 300 to 298 nm in the direction orthogonal to the grooves. This deformation shifted the resonance peak by 21.5 nm. These simulations indicated that both the elongation of the grating period and the small shrinkage of the diameter contributed to the ultra-wide tunability of the NFBC. We also calculated the dependence of the stress at the groove, the resonance wavelength, and the quality Q factor while changing the total elongation of the NFBC. The dependence of the stress on the elongation was 1.68 × 10−2 GPa/μm. The dependence of the resonance wavelength was 0.07 nm/μm, which almost agrees with the experimental result. When the NFBC, assumed to have the total length of 32 mm, was stretched by 380 μm with the tensile force of 250 μN, the Q factor for the polarization mode parallel to the groove changed from 535 to 443, which corresponded to a change in Purcell factor from 5.3 to 4.9. This slight reduction seems acceptable for the application as single photon sources. Furthermore, assuming a rupture strain of the nanofiber of 10 GPa, it was estimated that the resonance peak could be shifted by up to about 42 nm.
Short pulses from a gain-switched quantum cascade laser
Authors: Täschler Philipp , Miller Lucius , Kapsalidis Filippos , Beck Mattias , Faist Jérôme 
Published: March 2023

The picosecond carrier dynamics observed in quantum cascade lasers (QCLs) poses a fundamental obstacle for the formation of intracavity pulses. On the other hand, the ultrafast gain response makes the QCL ideally suited for high frequency modulation of its pump current. In this work, we leverage this property and use short electrical excitations to generate 33 ps optical pulses with up to Watt level peak power. We ensure lasing on a single resonator mode via optical injection seeding. The resulting pulses are characterized in both time and frequency domains using an optical sampling method in combination with a spectrometer. We interpret the obtained results using laser rate equations. The results presented in this work open new pathways for the generation of highly tunable, high power mid-infrared pulses from a monolithic source.
Polarization singularities in planar electromagnetic resonators with rotation and mirror symmetries
Authors: Yang Jie , Zheng Xuezhi , Wang Jiafu , Zhang Anxue , Cui Tie Jun , Vandenbosch Guy A. E. 
Published: March 2023

In this work, we apply the group representation theory to systematically study polarization singularities in the in-plane components of the electric fields supported by a planar electromagnetic (EM) resonator with generic rotation and reflection symmetries. We reveal the intrinsic connections between the symmetries and the topological features, i.e., the spatial configuration of the in-plane fields and the associated polarization singularities. The connections are substantiated by a simple relation that links the topological charges of the singularities and the symmetries of the resonator. To verify, a microwave planar resonator with the D8 group symmetries is designed and numerically simulated, which demonstrates the theoretical findings well. Our discussions can be applied to generic EM resonators working in a wide EM spectrum, such as circular antenna arrays, microring resonators, and photonic quasi-crystals, and provide a unique symmetry perspective on many effects in singular optics and topological photonics.
Macroscopic resting state model predicts theta burst stimulation response: A randomized trial
Authors: Kaboodvand Neda , Iravani Behzad , van den Heuvel Martijn P. , Persson Jonas , Boden Robert 
Published: March 2023

Repetitive transcranial magnetic stimulation (rTMS) is a promising alternative therapy for treatment-resistant depression, although its limited remission rate indicates room for improvement. As depression is a phenomenological construction, the biological heterogeneity within this syndrome needs to be considered to improve the existing therapies. Whole-brain modeling provides an integrative multi-modal framework for capturing disease heterogeneity in a holistic manner.
Computational modelling combined with probabilistic nonparametric fitting was applied to the resting-state fMRI data from 42 patients (21 women), to parametrize baseline brain dynamics in depression. All patients were randomly assigned to two treatment groups, namely active (i.e., rTMS, n = 22) or sham (n = 20). The active treatment group received rTMS treatment with an accelerated intermittent theta burst protocol over the dorsomedial prefrontal cortex. The sham treatment group underwent the identical procedure but with the magnetically shielded side of the coil.
We stratified the depression sample into distinct covert subtypes based on their baseline attractor dynamics captured by different model parameters. Notably, the two detected depression subtypes exhibited different phenotypic behaviors at baseline. Our stratification could predict the diverse response to the active treatment that could not be explained by the sham treatment. Critically, we further found that one group exhibited more distinct improvement in certain affective and negative symptoms. The subgroup of patients with higher responsiveness to treatment exhibited blunted frequency dynamics for intrinsic activity at baseline, as indexed by lower global metastability and synchrony.
Our findings suggested that whole-brain modeling of intrinsic dynamics may constitute a determinant for stratifying patients into treatment groups and bringing us closer towards precision medicine.