bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disease burden at time of transplant is a primary predictor of outcomes in pediatric MDS: A single center experience
Authors: Bleakley marie , Dahlberg Ann , Stevenson Phil , Bhatt Neel , Burroughs Lauri , Carpenter Paul , Mallhi Kanwaldeep , Summers Corinne , Tarlock Katherine , Thakar Monica , Milano Filippo , Deeg H. 
Published: July 2023

Abstract
Hematopoietic cell transplantation (HCT) remains the only curative therapy for pediatric myelodysplastic syndrome (MDS) in all but rare cases. While HCT outcomes for pediatric MDS are similar across the largest registry and single center trials, factors identified as contributing to inferior outcomes vary from study to study. We performed an analysis to provide more clarity on the prognostic implications of disease characteristics including blast burden and cytogenetic abnormalities in the current era. We conducted a retrospective analysis of 36 consecutive children (<18 years of age at HCT) who underwent allogeneic HCT for MDS between June 2000 and October 2019 at the Fred Hutchinson Cancer Center. Overall survival (OS) was 77% (95% CI 64-92%) and Relapse-free survival (RFS) was 71% (95% CI 57-88%) at 2-years post-HCT. Patients with < 5% blasts by morphology in the bone marrow at time of HCT showed superior 2-year OS at 87% (95% CI 74-100%) as compared to 54% (95% CI 32-93%) in patients with ≥5% blasts, consistent with an HR of 4.6 (CI 1.14-18.7, p=0.03). The inferior outcomes in patients with ≥ 5% blasts were due to increased relapse incidence (HR 7.6, CI 1.5-39.3) with no difference in NRM or acute GVHD. OS and RFS were comparable to what has been observed in other large, single center studies (OS 77%, RFS 71% at 2 years) and compared favorably to outcomes from the largest multi-center retrospective analyses. The primary disease factors that correlated with inferior OS and/or RFS and relapse were higher disease burden at time of HCT and administration of chemotherapy pre-HCT.
Serum Histones in Dogs with Septic Peritonitis as a Prognostic Biomarker
Authors: Handel Karin W. , Nivy Ran , Ginsburg Isaac , Avital Yochai , Horowitz Michal , Bruchim Yaron 
Published: July 2023

Abstract
Septic peritonitis (SP) is a life-threating condition. Extracellular histones exert cytotoxic, prothrombotic and proinflammatory effects. Determining prognosis for dogs suffering from SP remains challenging. Our objective was to investigate serum general histones concentrations (sHs) as biomarkers of disease severity and outcome in dogs with naturally occurring SP. Blood samples were collected upon admission and 24 hours post hospitalization from 21 dogs with SP and from 7 healthy controls. Serum general histone concentrations (median;IQR) upon admission were higher in dogs with SP compared to controls (34.2 ng/ml;39.1 ng/ml vs. 7.3 ng/ml;1.7 ng/ml; P = 0.001) and sHs significantly decreased 24 hours post-hospitalization (34.4 ng/ml; 39.3 ng/ml vs. 24.2 ng/ml; 11 ng/ml; P = 0.018). Serum histones were higher among survivors compared to non-survivors (45.5 ng/ml;37 ng/ml vs. 24.0 ng/ml;12 ng/ml; P = 0.03). This data demonstrates that serum general histone concentrations significantly increase in dogs with SP and decrease after hospitalization. Future studies are warranted to investigate the reverse relationship between outcome and sHs.
The Impact of Leprosy on Quality of Life of Patients and Their Families
Authors: Fouad Hager , Atallah Rabie Bedir , Fouda Ibrahim 
Published: July 2023

AbstractBackground Hansen's disease (HD), often known as leprosy, is a bacterial disease with a long history that is still prevalent today. This infection can manifest in a number of different ways, causing damage to peripheral nerves, skin, and testes. The functional activity limitations (FALs) caused by leprosy are well understood. Physical and mental well-being, autonomy, social connections, perspectives, and the natural setting all contribute to one's QoL. Aim to measure how leprosy affects patients' and their families quality of Life. Subject and Methods: This cross-sectional study involved 100 patients and their families. All of them were recruited from Dermatology, Venereology & Andrology Department Outpatient Clinics, Al-Azhar University Hospitals (Damietta), and Dermatology and Leprosy Hospitals in Tanta and Damietta. The quality of life of leprosy patients was evaluated using the Dermatology Life Quality Index (DLQI) Results There was a significant relationship among (DLQI) result of patients and different lesion sites except for mucous lesions. Regarding family questionnaire, participants reported to be sympathetic were the highest percent in Feeling to see leprosy patient and in Feeling to have a leprosy family member. Conclusion Disability is the most important element in determining how severely leprosy affects quality of life. Therefore, there is still a need to raise awareness about lepromatous leprosy and its effects on patients' quality of life and the general public's understanding of the disease.
Enhancement of synchronizability in chronic migraine patients related to the increase of connectome interhemispheric connectivity
Authors: Hüttebräucker Tomás , Planchuelo-Gómez Álvaro , García-Azorín David , Guerrero Ángel , de Luis-García Rodrigo , Risau-Gusman Sebastián 
Published: July 2023

Abstract
The structure of the brain can be characterized as a set of interconnected regions, using the concept of connectome. It has been shown that the connectome is altered in patients with migraine, presenting a series of structural connections differences with respect to healthy subjects. Relating these structural alterations to the specific characteristics of migraine is a difficult task. One approach is to study the effects of these alterations on the dynamic processes that can take place in the connectome. An ubiquitous process in brain networks is the synchronization of neuronal populations. It depends not only on the network but also on the properties of the units being synchronized. Fortunately, the contribution of the network structure can be calculated independently, thus defining the network synchronizability.
Connectome synchronizability and structural connectivity were assessed using diffusion-weighted magnetic resonance imaging data from 56 female patients with episodic migraine, 60 female patients with chronic migraine (CM) and 39 female healthy controls (HC). We found that whole-brain synchronizability was significantly larger in CM than in HC. The analysis of the synchronizability of subnetworks showed that differences between CM and HC were larger for subnetworks involving regions from different hemispheres. Moreover, the number of interhemispheric streamlines was significantly larger in CM than in HC, whereas no such difference appeared between intrahemispheric streamlines. The largest contributions to these differences come from the interhemispheric connections from three regions: left superior frontal gyrus, right precentral cortex, and right caudate.
The Collaborative Mobility Model based on the Archimedean Spiral of Group Intelligence
Authors: Shi Feiyang , Wang Wei , Zhang Yiguo 
Published: July 2023

Abstract
Existing mobility models in the military domain focus on reconnaissance, siege and tracking, with fewer node movement scenarios for high-altitude precision military strikes.This paper combines the motion characteristics of Archimedean spiral and the idea of cluster mobility model to cluster nodes within the cluster and use the cluster head node to control nodes within the cluster to achieve intelligent node control. And our model is compared with the classic PSO and RPGM models. Experiments show that our proposed mobile model has excellent network performance and movement capability compared to the POS and RPGM models, and has broad application prospects.
Evaluating evolutionary algorithms for simulating catchment response to river discharge
Authors: Singh Ravindra Kumar , Kumar Satish , Pasupuleti Srinivas , Villuri Vasanta Govind Kumar , Agarwal Ankit 
Published: July 2023

Abstract
Evolutionary algorithms (EAs) are proficient in solving the controlled, nonlinear multimodal, non-convex problems that limit the use of deterministic approaches. The competencies of EA have been applied in solving various environmental and water resources problems. In this study, the storm water management model (SWMM) was set up to authenticate the capability of the model for simulating catchment response in the upper Damodar River basin. Auto-calibration and validation of SWMM were done for the years 2002–2011 at a daily scale using three EAs: genetic algorithms (GAs), particle swarm optimisation (PSO) and shuffled frog leaping algorithm (SFLA). Statistical parameters like Nash–Sutcliffe effectiveness (NSE), percent bias (PBIAS) and root-mean-squared error–observations standard deviation ratio (RSR) were used to analyse the efficacy of the results. NSE and PBIAS values obtained from GA were superior, with the recorded flow with NSE and PBIAS ranging between 0.63 and 0.69 and between 1.12 and 9.81, respectively, for five discharge locations. The value of RSR was approximately 0 indicating the sensibly exceptional performance of the model. The results obtained from SFLA were robust and superior. Our results showed the prospective use and blending of the hydrodynamic model with EA would aid the decision-makers in analysing the vulnerability in river watersheds.
Tumor Microenvironment Heterogeneity, Potential Therapeutic Avenues,
and Emerging Therapies
Authors: Peng Xintong , Zheng Jingfan , Liu Tianzi , Zhou Ziwen , Song Chen , Geng Yan , Wang Zichuan , Huang Yan 
Published: July 2023

Objective:
This review describes the comprehensive portrait of tumor microenvironment
(TME). Additionally, we provided a panoramic perspective on the transformation and functions of the
diverse constituents in TME, and the underlying mechanisms of drug resistance, beginning with the
immune cells and metabolic dynamics within TME. Lastly, we summarized the most auspicious potential
therapeutic strategies.

Recent:
TME is a unique realm crafted by malignant cells to withstand the onslaught of endogenous
and exogenous therapies. Recent research has revealed many small-molecule immunotherapies exhibiting
auspicious outcomes in preclinical investigations. Furthermore, some pro-immune mechanisms
have emerged as a potential avenue. With the advent of nanosystems and precision targeting, targeted
therapy has now transcended the "comfort zone" erected by cancer cells within TME.

Conclusion:
The ceaseless metamorphosis of TME fosters the intransigent resilience and proliferation
of tumors. However, existing therapies have yet to surmount the formidable obstacles posed by
TME. Therefore, scientists should investigate potential avenues for therapeutic intervention and design
innovative pharmacological and clinical technologies.
Artificial Intelligence and Natural Language Processing Inspired Chabot
Technologies
Authors: Singh Deepti , Manju  , Jatain Aman 
Published: July 2023

Abstract:
Chatbots use artificial intelligence (AI) and natural language processing (NLP) algorithms
to construct a clever system. By copying human connections in the most helpful way possible,
chatbots emulate individuals and serve as virtual assistants. They easily interface and respond
to customers' requests. In the modern technical environment, these conversation agents or chatbots
are considered the next-generation invention. Chatbot has become more popular in the business
field right now as it can reduce customer service cost and handle multiple users at a time. There are
many techniques used to involve such intelligent experts in daily business. A comprehensive analysis
of the methods is needed to determine the viability of the different strategies. This paper tracks
the progress of this invention and further clarifies the influence of chatbots on numerous businesses.
Besides, a survey of the multiple chatbot methodologies suggested by various researchers is provided.
Along with the survey, a chatbot e-commerce customer service is designed to provide an efficient
and accurate answer for any query based on the dataset of frequently asked questions. This
chatbot can reduce customer service costs and can handle multiple customers at the same time.
Evaluating the Acceptability and Appropriateness of the Augmented Reality Home Assessment Tool (ARHAT): Qualitative Descriptive Study
Authors: Fields Beth , Fitzpatrick McKenzie , Kinney Lauryn , Lee Jenny , Sprecher Bryce , Tredinnick Ross , Ponto Kevin , Shin Jung-hye 
Published: July 2023

Abstract

Background
The Augmented Reality Home Assessment Tool (ARHAT) is a mobile app developed to provide rapid, highly accurate assessments of the home environment. It uses 3D-capture technologies to help people identify and address functional limitations and environmental barriers.

Objective
This study was conducted to gain stakeholder feedback on the acceptability and appropriateness of the ARHAT for identifying and addressing barriers within home environments.

Methods
A qualitative descriptive study was conducted because it allows for variability when obtaining data and seeks to understand stakeholders’ insights on an understudied phenomenon. Each stakeholder group (occupational therapists, housing professionals, and aging adult and caregiver “dyads”) participated in a 60-minute, web-based focus group via a secure Zoom platform. Focus group data were analyzed by 2 trained qualitative research team members using a framework method for analysis.

Results
A total of 19 stakeholders, aged from 18 to 85+ years, were included in the study. Of the occupational therapists (n=5, 26%), housing professionals (n=3, 16%), and dyads (n=11, 58%), a total of 32% (n=6) were male and 68% (n=13) were female, with most living in the Midwestern United States (n=10, 53%). The focus group data demonstrate the acceptability and appropriateness of the workflow, style, measurement tools, and impact of the ARHAT. All stakeholders stated that they could see the ARHAT being used at many different levels and by any population. Dyads specifically mentioned that the ARHAT would allow them to do forward planning and made them think of home modifications in a new light.

Conclusions
Stakeholders found the ARHAT to be acceptable and appropriate for identifying and addressing functional limitations and barriers in the home environment. This study highlights the importance of considering the workflow, style, measurement tools, and potential impact of home assessment technology early in the developmental process.
Postpandemic Evaluation of the Eco-Efficiency of Personal Protective Equipment Against COVID-19 in Emergency Departments: Proposal for a Mixed Methods Study (Preprint)
Authors: Berthelot Simon , Longtin Yves , Margni Manuele , Guertin Jason Robert , LeBlanc Annie , Marx Tania , Mangou Khadidiatou , Bluteau Ariane , Mantovani Diego , Mikhaylin Sergey , Bergeron Frédéric , Dancause Valérie , Desjardins Anne , Lahrichi Nadia , Martin Danielle , Sossa Charles Jérôme , Lachapelle Philippe , Genest Isabelle , Schaal Stéphane , Gignac Anne , Tremblay Stéphane , Hufty Éric , Bélanger Lynda , Beatty Erica 
Published: July 2023

BACKGROUND

The COVID-19 pandemic has had a profound impact on emergency department (ED) care in Canada and around the world. To prevent transmission of COVID-19, personal protective equipment (PPE) was required for all ED care providers in contact with suspected cases. With mass vaccination and improvements in several infection prevention components, our hypothesis is that the risks of transmission of COVID-19 will be significantly reduced and that current PPE use will have economic and ecological consequences that exceed its anticipated benefits. Evidence is needed to evaluate PPE use so that recommendations can ensure the clinical, economic, and environmental efficiency (ie, eco-efficiency) of its use.

OBJECTIVE

To support the development of recommendations for the eco-efficient use of PPE, our research objectives are to (1) estimate the clinical effectiveness (reduced transmission, hospitalizations, mortality, and work absenteeism) of PPE against COVID-19 for health care workers; (2) estimate the financial cost of using PPE in the ED for the management of suspected or confirmed COVID-19 patients; and (3) estimate the ecological footprint of PPE use against COVID-19 in the ED.

METHODS

We will conduct a mixed method study to evaluate the eco-efficiency of PPE use in the 5 EDs of the CHU de Québec-Université Laval (Québec, Canada). To achieve our goals, the project will include four phases: systematic review of the literature to assess the clinical effectiveness of PPE (objective 1; phase 1); cost estimation of PPE use in the ED using a time-driven activity-based costing method (objective 2; phase 2); ecological footprint estimation of PPE use using a life cycle assessment approach (objective 3; phase 3); and cost-consequence analysis and focus groups (integration of objectives 1 to 3; phase 4).

RESULTS

The first 3 phases have started. The results of these phases will be available in 2023. Phase 4 will begin in 2023 and results will be available in 2024.

CONCLUSIONS

While the benefits of PPE use are likely to diminish as health care workers’ immunity increases, it is important to assess its economic and ecological impacts to develop recommendations to guide its eco-efficient use.

CLINICALTRIAL

PROSPERO CRD42022302598; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=302598

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/50682
APLIKASI METODE VLF (VERY LOW FREQUENCY) DAN METODE RESISTIVITAS UNTUK ESTIMASI SEBARAN LAVA BASALT BERSTRUKTUR BANTAL DI DAERAH WATUADEG KABUPATEN SLEMAN YOGYAKARTA
Authors: Adrian Adrian Rahmat Nur , Sastrawan Febrian Dedi , Sadjab Bayu Achil , Sismanto Sismanto 
Published: July 2023

Penelitian tentang estimasi sebaran lava basalt berstruktur bantal telah di lakukan di daerah Watuadeg Kecamatan Berbah Kabupaten Sleman D.I. Yogyakarta dengan menggunakan metode VLF (Very Low Frequency) dan metode resistivitas untuk mengetahui variasi nilai rapat arus ekuivalen dan resistivitas bawah permukaan, serta arah penyebaran lava bantal. Pengukuran metode VLF sebanyak 5 lintasan yang berarah Barat – Timur dan 3 lintasan berarah Utara – Selatan. Pengukuran metode resistivitas sebanyak 9 titik dengan setengah panjang bentangan (AB/2) adalah 200 meter dalam area pengukuran 2 km2. Hasil pengolahan data resistivitas menunjukkan nilai variasi resistivitas bawah permukaan adalah 10,9 Ωm– 109 Wm yang diidentifikasi sebagai resistivitas soil, 32,3 Ωm – 122 Ωm diindikasikan sebagai resistivitas tuf, 286 Ωm – 888 Ωm diidentifikasi sebagai resistivitas lava bantal, 112 Ωm – 167 Ωm diidentifikasi sebagai resistivitas aglomerat dan 2,72 Ωm – 36,2 Ωm diindikasikan sebagai resistivitas lempung. Nilai rapat arus ekuivalen (RAE) di daerah Watuadeg bervariasi antara 60 % - 240 %. Berdasarkan hasil korelasi antar penampang RAE dengan penampang korelasi resistivitas diperkirakan bahwa sebaran lava basalt berstruktur bantal di daerah Watuadeg bersumber dari bukit yang terletak di sebelah Barat kali Opak dengan arah sebarannya menerus ke arah Selatan.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE INDEX CARD MATCH (ICM) TERHADAP HASIL BELAJAR PESERTA DIDIK MATERI IPS KELAS V SD ISLAM AL FALAH JAMBI
Authors: Apriyanti Ayu , Mukminin Amirul , Hidayat Marzul 
Published: July 2023

Penelitian ini bertujuan untuk menjelaskan peningkatan keaktifan dan hasil belajar siswa dengan penerapan model Index Card Match (ICM). Penelitian dilaksanakan di SD Islam Al-Falah Jambi. Subjek penelitian adalah siswa kelas VB. Penelitian ini merupakan penelitian tindakan kelas yang dilaksananakan dalam satu siklus yaitu dua pertemuan dimulai dengan perencanaan, pelaksanaan, pengamatan, dan refleksi. Teknik pengumpulan data yang digunakan adalah observasi (pengamatan) dan dokumentasi. Teknik analisis data dilakukan secara induktif, yaitu dimulai dari lapangan atau fakta empiris dengan terjun ke lapangan. Analisis data dalam penelitian kualitatif dilakukan secara bersamaan dengan proses pengumpulan data. Hasil penelitian dari siklus pertama ke siklus kedua menunjukkan terjadinya peningkatan keaktifan dan hasil belajar siswa. Hasil penelitian menunjukkan bahwa 18 dari 22 siswa menjadi aktif. Sementara untuk hasil belajar juga mengalami peningkatan yaitu 68,18% siswa yang tuntas pada pertemuan pertama menjadi 86,36% siswa yang tuntas pada pertemuan kedua. Peneliti menarik kesimpulan bahwa model ICM mampu meningkatkan keaktifan dan hasil belajar siswa dalam pembelajaran IPS Kelas VD SD Islam Al-Falah Jambi.
Kata kunci: Model Index Card Match, Keaktifan, Hasil Belajar
DETERMINING THE RIGHT DOSAGE OF INORGANIC FERTILIZERS TO INCREASE GROWTH AND RESULTS THREE LOCAL UPLAND RICE CULTIVARS
Authors: Made Usman , Mustakim Mustakim 
Published: July 2023

Fertilization is one of the important factor to increase production. The aim of this study was to determine the appropriate dosage of inorganic fertilizers to increase the growth and yield of three cultivars of upland rice. This research was conducted at the Center for Research and Development of Gogo Rice, Faculty of Agriculture, Tadulako University, Kalama, Tamarenja Village at an altitude of 180 to 250 above sea level with a latitude of 00o 26'51.5” South Latitude and 119o49'50.6” East Latitude, Sindue District, Donggala Regency, Central Sulawesi Province. The time of the research started from March to August 2020. This research was compiled and carried out using the factorial 2 factors Randomized Block Design (RBD) method. The first factor used three local upland rice cultivars, namely: Pae Bohe, Buncaili, and Uva Buya, while the second factor used six doses of inorganic fertilizers, namely: No fertilization, NPK fertilization 100 kg/ha, 200 kg/ha, 300 kg/ha, 400 kg/ha, and 500 kg/ha. There were 18 combinations, where each treatment was repeated three times so that there were 54 research units. Parameters observed included plant height, number of productive tillers, age of panicle appear, harvest age, number of panicle grains, percentage of empty grain, 1000 grain weight and production. The results showed that the Pae bohe cultivar with fertilization dose of 500 kg/ha produced the highest number of productive tillers (6.69 per clump), the lower percentage of grain pests (5.34%), and the highest production (3.82 tons/ha).
Political Reforms For Regime Survival: Algeria From 1988 To Post-Covid-19 Era
Authors: Khelfa Nouha , Zamani Sayed Mustafa 
Published: July 2023

This study examines how the regime in Algeria could survive the different popular uprisings throughout history, unlike the rest of regimes that experienced the Arab Spring. The study argues that since the foundation of the republic, the Algerian regime has always supported quick political reforms as a survival tactic. Contrary to other Arab dictatorships, the FLN has always been in power, but, as a survival tactic, it has always been willing to make concessions. The Algerian government used immediate political reforms to dictate the populace's behavior during uprisings, which over time created a kind of negative reinforcement. The study will employ an extensive literature review and archival records to support this argument. Relying on a fusion of classical conditioning, power-maximization theory and inherent factors approach, this study will prove that political reforms are used mostly as a tool of regime survival and power maximization.