bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caring for Caregivers to Be
Authors: Charney Dennis S. 
Published: May 2023

Abstract
This book provides a scoping summary review of the evidence related to medical student and graduate medical trainee well-being, enabling readers to make use of a variety of tools and instruments believed to have impact on reducing burnout and promoting the development of a resilient and professionally fulfilled physician work force. Areas of focus described within this edited volume include an overview of models and terminology for well-being, the prevalence of burnout and depression in medical trainees, major drivers contributing to burnout and well-being, and the consequences of suboptimal well-being. Using the most current supporting evidence, the book then describes practical considerations for initiating and implementing comprehensive solutions-based well-being programs. Readers will also learn strategies to “make the case” within their organization for directing resources to address medical student and graduate medical trainee well-being, and they can explore opportunities for advocacy in support of well-being at a societal level.
Advocating for Physician Well-Being at the Societal Level
Authors: Sinsky Christine A. , Ristow Alexandra M. 
Published: May 2023

Abstract
This chapter examines the role of advocacy in promoting physician well-being. Addressing physician burnout is a shared responsibility and opportunity. Four levers of advocacy to improve the US health care system’s ability to care for its physicians are explored: research, activation, resources, and workforce demand. Recommendations for research to advance the science of practice that will help improve the clinical environment and thus reduce physician burnout are presented. Examples of activation at the individual, institutional, and national levels are shared. Resources that provide actionable guidance for policy, practice, and leadership changes to support well-being are highlighted. Finally, the power of workforce demand is addressed. Physician burnout is primarily driven by systems factors, so the focus of efforts to improve well-being is on fixing the workplace rather than fixing the worker. The system is broken, not the people within it.
Current landscape of social media use pertaining to glioblastoma by various stakeholders
Authors: Alvi Mohammed Ali , Elkaim Lior M , Levett Jordan J , Pando Alejandro , Roy Sabrina , Samuel Nardin , Alotaibi Naif M , Zadeh Gelareh 
Published: May 2023

AbstractBackgroundGiven the potential for social media to allow widespread public engagement, its role in healthcare, including in cancer care as a support network, is garnering interest. To date, the use of social media in neuro-oncology has not been systematically explored. In the current manuscript, we sought to review Twitter use on glioblastoma among patients, caregivers, providers, researchers, and other stakeholders.MethodsThe Twitter application programming interface (API) database was surveyed from inception to May 2022 to identify tweets about glioblastoma. Number of tweet likes, retweets, quotes, and total engagement were noted for each tweet. Geographic location, number of followers, and number of Tweets were noted for users. We also categorized Tweets based on their underlying themes. A natural language processing (NLP) algorithm was used to assign a polarity score, subjectivity score, and analysis label to each Tweet for sentiment analysis.ResultsA total of 1690 unique tweets from 1000 accounts were included in our analyses. The frequency of tweets increased from 2013 and peaked in 2018. The most common category among users was MD/researchers (21.6%, n = 216), followed by Media/News (20%, n = 200) and Business (10.7%); patients or caregivers accounted for only 4.7% (n = 47) while medical centers, journals, and foundations accounted for 5.4%, 3.7%, and 2.1%. The most common subjects that Tweets covered included research (54%), followed by personal experience (18.2%) and raising awareness (14%). In terms of sentiment, 43.6% of Tweets were classified as positive, 41.6% as neutral, and 14.9% as negative; a subset analysis of “personal experience” tweets revealed a higher proportion of negative Tweets (31.5%) and less neutral tweets (25%). Only media (β = 8.4; 95% CI [4.4, 12.4]) and follower count (minimally) predicted higher levels of Tweet engagement.ConclusionThis comprehensive analysis of tweets on glioblastoma found that the academic community are the most common user group on Twitter. Sentiment analysis revealed that most negative tweets are related to personal experience. These analyses provide the basis for further work into supporting and developing the care of patients with glioblastoma.
Ir0/graphdiyne atomic interface for selective epoxidation
Authors: Zheng Zhiqiang , Qi Lu , Gao Yaqi , Luan Xiaoyu , Xue Yurui , He Feng , Li Yuliang 
Published: May 2023

ABSTRACT
The development of catalysts that can selectively and efficiently promote the alkene epoxidation at ambient temperatures and pressures is an important promising path to renewable synthesis of various chemical products. Here we report a new type of zerovalent atom catalysts comprised of zerovalent Ir atoms highly dispersed and anchored on graphdiyne (Ir0/GDY) wherein the Ir0 is stabilized by the incomplete charge transfer effect and the confined effect of GDY natural cavity. The Ir0/GDY can selectively and efficiently produce styrene oxides (SO) by electro-oxidizing styrene (ST) in aqueous solutions at ambient temperatures and pressures with high conversion efficiency of ∼100%, high SO selectivity of 85.5%, and high Faradaic efficiency (FE) of 55%. Experimental and density functional theory (DFT) calculation results show that the intrinsic activity and stability due to the incomplete charge transfer between Ir0 and GDY effectively promoted the electron exchange between the catalyst and reactant molecule, and realized the selective epoxidation of ST to SO. Studies of the reaction mechanism demonstrate that Ir0/GDY proceeds a distinctive pathway for highly selective and active alkene-to-epoxide conversion from the traditional processes. This work presents a new example of constructing zerovalent metal atoms within the GDY matrix toward selective electrocatalytic epoxidation.
Advice to remain active with arm pain reduces disability
Authors: Walker-Bone K , Macfarlane G J , Burton K , McConnachie A M , Zhang R , Jones G T 
Published: May 2023

Abstract

Background
Arm pain is common amongst working-aged adults and causes substantial work disability. The results of a population-based randomized controlled trial (the ARM trial) suggested that advice to remain active reduced disability after 6 months.

Aims
To verify ARM trial results amongst people in paid employment.

Methods
The ARM trial recruited adults with distal arm pain referred for physiotherapy and randomized equally to three groups: wait-listed for physiotherapy (advised to rest); wait-listed for physiotherapy (advised to remain active) or early physiotherapy. The primary outcome was absence of disability at 26 weeks. Secondary analyses were undertaken amongst participants in paid employment.

Results
Amongst 538 trial participants, 347 (64%) were in paid employment, mean age 46.1 years and 47% in manual work. Employed participants were randomized equally to the three arms. Amongst the 271 (78% workers with 26-week data), 43% of those advised to remain active were free from disability, as compared with 37% of those advised to rest. Forty per cent of those who waited for physiotherapy were disability-free as compared with 35% of those treated rapidly. Advice to rest was associated with lower chances of recovery amongst workers who lift/carry weights and those who believed work had caused their symptoms (P = 0.023).

Conclusions
Although not powered as a trial for workers only, our findings suggest that advising activity was as beneficial for people currently in paid work and may be superior to advice to rest in reducing disability. Addressing harmful beliefs about causation of symptoms has the potential to reduce disability.
Very long baseline interferometry imaging of H2O maser emission in the nearby radio galaxy NGC 4261
Authors: Sawada-Satoh Satoko , Kawakatu Nozomu , Niinuma Kotaro , Kameno Seiji 
Published: May 2023

Abstract
We report dual-frequency very long baseline interferometry (VLBI) observations at 22 and 43 GHz toward the nucleus of a nearby radio galaxy NGC 4261. In particular, we present a VLBI image of the 22 GHz H2O maser line and its location in the circumnuclear region of NGC 4261. H2O maser emission is marginally detected above the three times the image rms level at channels within a velocity range of approximately 2250–2450 km s−1, slightly red-shifted with respect to the systemic velocity. H2O maser emission is located approximately 1 milliarcsecond east of the brightest continuum component at 22 GHz, where the continuum spectrum is optically thick, that is, at the free–free absorbed receding jet by ionized gas. A positional coincidence between H2O maser emission and an ionized gas disk implies that the H2O maser emission arises from the near side of the disk, amplifying continuum emission from the background receding jet. If the disk axis is oriented 64° relative to the line of sight, the H2O maser emission is expected to be at a mean radius of 0.3 pc in the disk. The broad line width of the H2O maser emission can be attributed to complex kinematics in the immediate vicinity of the supermassive black hole (SMBH), including ongoing gas infall on to the SMBH, turbulence, and outflow. This is analogous to the multi-phase circumnuclear torus model in the nearest radio-loud H2O megamaser source NGC 1052. An alternative explanation for H2O maser association is the shock region between the jet and ambient molecular clouds. However, this explanation fails to describe the explicit association of H2O maser emission only with the free–free absorbed receding jet.
Current Insights into the Redox Regulation Network in Plant Chloroplasts
Authors: Yoshida Keisuke , Hisabori Toru 
Published: May 2023

AbstractThiol/disulfide-based redox regulation is a ubiquitous post-translational protein modification. In plant chloroplasts, this regulatory mechanism is tightly associated with the light-dependent activation of photosynthetic enzymes (e.g. Calvin–Benson cycle enzymes). A thioredoxin (Trx)-mediated pathway was discovered to transmit light signals as a reducing power about half a century ago; since then, it has been accepted as the basic machinery of chloroplast redox regulation. However, during the past two decades, it has been increasingly apparent that plants have acquired multiple Trx isoforms and Trx-like proteins in chloroplasts. Furthermore, proteomics-based analyses have identified various chloroplast enzymes as potential targets of redox regulation. These facts highlight the necessity to revisit the molecular basis and physiological importance of the redox regulation system in chloroplasts. Recent studies have revealed novel aspects of this system, including unprecedented redox-regulated processes in chloroplasts and the functional diversity of Trx family proteins. Of particular significance is the identification of protein-oxidizing pathways that turn off photosynthetic metabolism during light-to-dark transitions. In this review, we summarize current insights into the redox regulation network in chloroplasts.
A Tunisian wild grape leads to metabolic fingerprints of salt tolerance
Authors: Daldoul Samia , Gargouri Mahmoud , Weinert Christoph , Jarrar Ali , Egert Björn , Mliki Ahmed , Nick Peter 
Published: May 2023

Abstract
Soil salinity is progressively impacting agriculture, including viticulture. Identification of genetic factors rendering grapevine (Vitis vinifera L.) resilience that can be introgressed into commercial varieties is necessary for safeguarding viticulture against the consequences of global climate change. To gain insight into the physiological and metabolic responses enabling salt tolerance, we compared a salt-tolerant accession of Vitis sylvestris from Tunisia, “Tebaba”, with “1103 Paulsen” rootstock widely used in the Mediterranean. Salt stress was slowly increased, simulating the situation of an irrigated vineyard. We determined that “Tebaba” does not sequester sodium in the root but can cope with salinity through robust redox homeostasis. This is linked with rechanneling of metabolic pathways toward antioxidants and compatible osmolytes, buffering photosynthesis, such that cell-wall breakdown can be avoided. We propose that salt tolerance of this wild grapevine cannot be attributed to a single genetic factor but emerges from favorable metabolic fluxes that are mutually supportive. We suggest that introgression of “Tebaba” into commercial varieties is preferred over the use of “Tebaba” as a rootstock for improving salt tolerance in grapevine.
Hydrogen peroxide sensor HyPer7 illuminates tissue-specific plastid redox dynamics
Authors: Dopp Isaac J , Kalac Kylie , Mackenzie Sally A 
Published: May 2023

AbstractThe visualization of photosynthesis-derived reactive oxygen species has been experimentally limited to pH-sensitive probes, unspecific redox dyes, and whole-plant phenotyping. Recent emergence of probes that circumvent these limitations permits advanced experimental approaches to investigate in situ plastid redox properties. Despite growing evidence of heterogeneity in photosynthetic plastids, investigations have not addressed the potential for spatial variation in redox and/or reactive oxygen dynamics. To study the dynamics of H2O2 in distinct plastid types, we targeted the pH-insensitive, highly specific probe HyPer7 to the plastid stroma in Arabidopsis (Arabidopsis thaliana). Using HyPer7 and glutathione redox potential (EGSH) probe for redox-active green fluorescent protein 2 genetically fused to the redox enzyme human glutaredoxin-1 with live cell imaging and optical dissection of cell types, we report heterogeneities in H2O2 accumulation and redox buffering within distinct epidermal plastids in response to excess light and hormone application. Our observations suggest that plastid types can be differentiated by their physiological redox features. These data underscore the variation in photosynthetic plastid redox dynamics and demonstrate the need for cell-type-specific observations in future plastid phenotyping.
Cell signaling in the shoot apical meristem
Authors: Wang Ying , Jiao Yuling 
Published: May 2023

AbstractDistinct from animals, plants maintain organogenesis from specialized tissues termed meristems throughout life. In the shoot apex, the shoot apical meristem (SAM) produces all aerial organs, such as leaves, from its periphery. For this, the SAM needs to precisely balance stem cell renewal and differentiation, which is achieved through dynamic zonation of the SAM, and cell signaling within functional domains is key for SAM functions. The WUSCHEL-CLAVATA feedback loop plays a key role in SAM homeostasis, and recent studies have uncovered new components, expanding our understanding of the spatial expression and signaling mechanism. Advances in polar auxin transport and signaling have contributed to knowledge of the multifaceted roles of auxin in the SAM and organogenesis. Finally, single-cell techniques have expanded our understanding of the cellular functions within the shoot apex at single-cell resolution. In this review, we summarize the most up-to-date understanding of cell signaling in the SAM and focus on the multiple levels of regulation of SAM formation and maintenance.
Deadly Debt Crises: COVID-19 in Emerging Markets
Authors: Arellano Cristina , Bai Yan , Mihalache Gabriel 
Published: May 2023

Abstract
Emerging markets have experienced large human and economic costs from coronavirus disease 2019, and their tight fiscal space has limited the support extended to their citizens. We study the impact of an epidemic on economic and health outcomes by integrating epidemiological dynamics into a sovereign default model. The sovereign’s option to default tightens fiscal space and results in an epidemic with limited mitigation and depressed consumption. A quantitative analysis of our model accounts well for the dynamics of fatalities, social distancing, consumption, sovereign debt, and spreads in Latin America. We find that because of default risk, the welfare cost of the pandemic is about a third higher than it is in a version of the model with perfect financial markets. We study debt relief programs and find a compelling case for their implementation. These programs deliver large social gains, improving health and economic outcomes for the country at no cost to international lenders or financial institutions.
Implications of the accuracy of diagnostic algorithms for systemic lupus on our understanding of racial disparities in pregnancy outcomes
Authors: Clowse Megan E B , Oates James , Barnado April , Kirchoff Katie , Blaske Ashley , Sheikh Saira Z , Crofford Leslie J , Eudy Amanda M 
Published: May 2023

Abstract

Objective
Disparities in pregnancy outcomes among women with SLE remain understudied, with few available racially diverse datasets. We sought to identify disparities between Black and White women in pregnancy outcomes within academic institutions in the United States.

Methods
Using the Common Data Model electronic medical record (EMR)-based datasets within the Carolinas Collaborative, we identified women with pregnancy delivery data (2014–2019) and ≥1 SLE International Classification of Diseases 9 or 10 code (ICD9/10) code. From this dataset, we identified four cohorts of SLE pregnancies, three based on EMR-based algorithms and one confirmed with chart review. We compared the pregnancy outcomes identified in each of these cohorts for Black and White women.

Results
Of 172 pregnancies in women with ≥1 SLE ICD9/10 code, 49% had confirmed SLE. Adverse pregnancy outcomes occurred in 40% of pregnancies in women with ≥1 ICD9/10 SLE code and 52% of pregnancies with confirmed SLE. SLE was frequently over-diagnosed in women who were White, resulting in 40–75% lower rates of adverse pregnancy outcomes in EMR-derived vs confirmed SLE cohorts. Over-diagnosis was less common for Black women with pregnancy outcomes 12–20% lower in EMR-derived vs confirmed SLE cohorts. Black women had higher rates of adverse pregnancy outcomes than White women in the EMR-derived, but not the confirmed cohorts.

Conclusion
EMR-derived cohorts of pregnancies in women who are Black, but not White, provided accurate estimations of pregnancy outcomes. The data from the confirmed SLE pregnancies suggest that all women with SLE, regardless of race, referred to academic centres remain at very high risk for adverse pregnancy outcome.
The issue of Cs-137 in firewood and biomass combustion: a review
Authors: Pepin Stéphane , Radulovic Sarah , Wiegers Rob , Mrdakovic Popic Jelena , Kallio Antti , Huss Marie , Grandia Fidel , Valls Alba , Bruno Aina 
Published: May 2023

AbstractIn large parts of Europe, the Chernobyl accident of 1986 caused fallout of Cs-137. This led to the uptake of Cs-137 in trees or other materials used for bioenergy production or as firewood for domestic purposes. This Cs-137 may concentrate in the ashes of the combustion process in such a way that the clearance level of 100 Bq per kg, defined in Directive 2013/59/Euratom (EU BSS), may consequently be exceeded. There is currently no clear consensus in Europe regarding the regulatory approach to this issue: should the import and use of Cs-137 contaminated biomass and its ashes be considered as a planned exposure situation or rather as an existing exposure situation? If considered as an existing exposure situation, which reference level should be applied? We compare the approaches in various European countries, such as Finland, Norway, Sweden, Belgium and the Netherlands. Results of a recent measurement campaign performed in Belgium on firewood imported from Belarus, Ukraine and other countries show a quite large range of Cs-137 activity concentration in firewood. Analysis of samples from biomass combustion confirms that the clearance level of 100 Bq per kg Cs-137 may be exceeded even when the activity concentration in the initial pellet is trivial. A review of dose-assessment studies performed by STUK and from the literature is presented. The general context of biomass energy production is sketched: for instance, in the Netherlands, 40 large biomass firing plants (capacity &gt; 10 MW) are operational and some 20 more are already planned. The fly ashes from the biomass combustion may be a valuable resource for the construction industry, and the issue of Cs-137 contamination is connected with the requirements of the EU BSS regarding the natural radioactivity of building materials. Assessing the impact of Cs-137 contamination and clarifying regulations in the frame of a graded approach are important elements in this context.
Radiation protection challenges in the upgrade, autopsy and disposal of the LHC beam dump
Authors: Infantino Angelo , Bernardes Ana-Paula , Calviani Marco , Dumont Gerald , El-Idrissi Safouane , Mouret Renaud , Tromel Christophe , Vincke Heinz 
Published: May 2023

Abstract
The upgrade of the Large Hadron Collider spare beam dumps (Target Dump External, TDE) and the autopsy of the old operational TDE required to perform several activities in a high-radiation environment posing significant radiation protection challenges due to the residual activation of the equipment. To ensure high safety standards and to respect the ALARA principle, these challenges were addressed using the advanced Monte Carlo techniques to predict the residual ambient dose equivalent rate and the radionuclide inventory at different steps of the interventions. The CERN HSE-RP group makes extensive use of the FLUKA and ActiWiz codes to produce accurate estimates. This work aims to provide an overview of the radiation protection studies to optimise the interventions (ALARA) and to reduce the radiological risk for personnel and environment.
Radiation protection challenges for the Large Hadron Collider upgrade
Authors: Elie Lucie , Dyrcz Patrycja , Infantino Angelo , Tromel Christophe , Vincke Heinz 
Published: May 2023

Abstract
In the context of the so-called Long Shutdown 3 (2026–2028), the Large Hadron Collider will be upgraded to the High-Luminosity Large Hadron Collider, allowing for approximately five more instantaneous collisions. The upgrade, maintenance and decommissioning of equipment will be mainly performed in the experimental insertions of Points 1 and 5, requiring to perform multiple interventions in high-residual radiation environment. This poses complex radiological challenges that the CERN Radiation Protection group is called to address. Radiation protection studies are performed to plan and optimise (ALARA) these future interventions using the advanced Monte Carlo techniques and tools such as FLUKA, ActiWiz, SESAME and the FCC method. This paper aims to provide an overview of the studies conducted to estimate the residual radiation field in the experimental insertions, the activation levels in terms of multiple of the Swiss clearance limits/specific activity and to provide preliminary considerations on the upgrade/decommissioning of key equipment.