bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying Model‐Based Systems Engineering Methods to a Novel Shared Systems Simulation Methodology
Authors: Ross Jeremy , Vinarcik Michael , Caron Christopher , Craft Christopher , Pien Stephen , Prajapati Ashishkumar 
Published: July 2023

AbstractThe need to develop increasingly complex, integrated systems and multi‐domain systems‐of‐systems is initiating a transformation within the discipline of systems engineering. The critical trends of increasing interconnectivity, compressed development times, growing cybersecurity concerns, and a rapidly changing workforce are driving current systems engineering practices into obsolescence. Model‐Based Systems Engineering (MBSE) is a formalized approach to systems engineering that uses models as an integral component of a system's technical definition with the objective of enhancing communication through rigor and precision and managing system complexity. This paper discusses the application of MBSE methods to the definition of a shared systems architecture and the development of novel methodologies for extending the model‐based approach from the system definition space into the system simulation and analysis domain. Approaches for interface management of design properties between a model‐based architecture and system simulation will be reviewed, with the effectiveness of each approach discussed.
How Does a Stone Carver Create? A Participatory Case Study
Authors: Botella Marion , Robieux Léonore , Frantz Benjamin 
Published: July 2023

ABSTRACTArt and design involve divergent creative processes. Design is a more constrained domain than art. While creativity in some specific domains, such as painting, sculpture, and music, has been widely studied, some have as yet been little explored. One example is stone carving. What characterizes stone carving, as a creative occupation? What is a stone carver's creative process? We set out to answer these questions by interviewing a stone carver about his profession, his process, his productions, and his place in society. In this case study, we examined the stone carver's discourse using a combination of three content analysis software tools. Taken together, the results highlight and detail 3 of the 7 Cs of creativity: the stone carver as creator, his creating (creative process), and his creations (productions) on which the interview focuses. The results of this participatory case study were validated by the stone carver himself. They reveal that stone carving sits at the intersection between handicraft, design, and art.
Increase in colour stability of pomegranate juice against 5‐hydroxymethylfurfural (HMF) through copigmentation with phenolic acids
Authors: Türkyılmaz Meltem , Hamzaoğlu Fatmagül , Çiftci Rumeysa Betül Arı , Özkan Mehmet 
Published: July 2023

AbstractBACKGROUNDAnthocyanins are responsible for both attractive colour of pomegranate juice (PJ) and its health‐promoting effects against cancer and coronary heart disease. However, 5‐hydroxymethylfurfural (HMF) at some concentrations causes anthocyanin degradation. The present study aimed to reduce the degradation of PJ anthocyanins as a result of HMF at various concentrations (0–20 mg L−1) through phenolic acid [PA; ferulic (FA), gallic (GA) and caffeic acids (CA)] copigmentation during storage at 20 °C.RESULTSA strong correlation (r = 0.872) was found between anthocyanin degradation rate and HMF concentration in PJ without PA addition. An increase in HMF concentration during storage caused faster (< 32%) anthocyanin degradation. However, PA addition reduced (< 60 times) the HMF formation rate. The lowest HMF formation rates (0.07–0.28 day−1) were determined in PJ with added GA. Although GA caused an important increase in content of cyanidin‐3‐glucoside (16–42%), which is major PJ anthocyanin, against HMF at all concentrations, CA (15%) and FA (28%) increased cyanidin‐3‐glucoside content against 10 mg of HMF L−1. FA maintained its protection effect against the highest HMF concentration (20 mg of HMF L−1), but CA lost its protection effect. Generally, FA increased stabilities of hyperchromic effect (HE) (9.6–27.7%) and colour density (CD) (57.1–74.3%) at all HMF concentrations, although CA increased HE stability (19.8–37.7%) in the presence of 10 and 20 mg of HMF L−1. Interactions of ‘all individual anthocyanins‐FA’ and ‘delphinidin‐based anthocyanins‐GA/CA’ resulted in copigmentation.CONCLUSIONFA addition was recommended to increase CD and HE for PJ containing HMF between 3.1–5.6 mg L−1, whereas the addition of GA was recommended to increase anthocyanin stability for PJ containing 12.0 mg of HMF L−1. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Closure of pelvic peritoneum with bladder peritoneum flap reconstruction after laparoscopic extralevator abdominoperineal excision: A prospective stage II study
Authors: Shen Yu , Yang Ting‐Han , Deng Xiangbing , Wu Qingbin , Wei Mingtian , Meng Wenjian , Wang Zi‐Qiang 
Published: July 2023

AbstractBackgroundExtralevator abdominoperineal resection (ELAPE) has increased perineal wound complications due to the extended resection area. Closure of the pelvic peritoneum (CPP) may exclude the abdominal content from descending into the pelvic cavity and reduce the incidence of perineal complications after ELAPE. We have previously introduced bladder peritoneum flap reconstruction (BLAPER) as a novel method for patients in whom traditional CPP is not possible. The aim of the present study was to report the development and preliminary outcomes of BLAPER.MethodsThis is a prospective single‐arm study at the development and exploration phase and fulfills the IDEAL framework stage II. Ultralow rectal cancer patients with rigid pelvis who underwent ELAPE with BLAPER were enrolled. Primary outcomes were intraoperative complications and postoperative complications within 1 month after surgery.ResultsAmong 27 patients included, the overall success rate of BLAPER was 96.3% (26/27). Indocyanine green fluorescence imaging and antiadhesive barrier placement were introduced to improve the BLAPER technique. The incidence of major pelvic wound complications was 7.7%. No patient who underwent BLAPER has suffered small bowel obstruction (SBO), presence of small bowel in the retrourogenital space, or perineal hernia (PH).ConclusionsBLAPER is safe and may prevent the small bowel from descending into the retrourogenital space and subsequently developing PH and SBO without increasing the intraoperative and postoperative complications. BLAPER may serve as an option when the primary suture of the pelvic peritoneum is not feasible.
Bio‐Inspired Conductive Hydrogels with High Toughness and Ultra‐Stability as Wearable Human‐Machine Interfaces for all Climates
Authors: Cui Zeyu , Liu Chen , Fang Shiqiang , Xu Junbin , Zhao Zhi , Fang Jiaquan , Shen Zehao , Cong Zhenhua , Niu Jian 
Published: July 2023

AbstractDrawing inspiration from Salicornia, a plant with the remarkable ability to thrive in harsh environments, a conductive hydrogel with high toughness and ultra‐stability is reported. Specifically, the strategy of pre‐cross‐linking followed by secondary soaking in saturated salt solutions is introduced to prepare the PAAM‐alginate conductive hydrogel with dual cross‐linked dual network structure. It allows the alginate network to achieve complete cross‐linking, fully leveraging the structural advantages of the PAAM‐alginate conductive hydrogel. The highest tensile strength of the obtained conductive hydrogel is 697.3 kPa and the fracture energy can reach 69.59 kJ m−2, significantly higher than human cartilage and natural rubbers. Specially, by introducing saturated salt solutions within the hydrogel, the colligative properties endow the PAAM‐alginate conductive hydrogel with excellent water retention and anti‐freezing properties. The prepared conductive hydrogels can work stably in an ambient environment for more than 7 days and still maintain good mechanical behavior and ionic conductivity at −50 °C. Benefiting from the excellent comprehensive performance of conductive hydrogels, wearable human‐machine interfaces that can withstand large joint movements and are adapted for extreme environments are prepared to achieve precise control of robots and prostheses, respectively.
An improved GNSS remote sensing technique for 3D distribution of tropospheric water vapor
Authors: Long Ankang , Ye Shirong , Xia Pengfei 
Published: July 2023

AbstractWater vapor plays an extremely important role in the monitoring and prediction of weather, and GNSS tomography can obtain 3D spatiotemporal change information and reliable water vapor profiles. In this paper, an improved global navigation satellite system (GNSS) tropospheric tomography technique using an ERA5 (the fifth generation ECMWF reanalysis) product is developed. First, the ERA5 product was adopted to analyze the spatiotemporal distribution of water vapor, and a water vapor density threshold defining the top of the tomography was determined; then, the height of the grid top (GT) of different seasons was obtained through linear fitting; finally, the water vapor value between GT and tropopause is constrained using the data of the ERA5 product as the initial value. The new method for using the ERA5 product to determine the height of the GT of the tomographic grid reduces the height of the top layer of the grid and increases the number of effective GNSS rays. Data from nine CORS stations in Hong Kong in 2019 were selected for experiments. The results showed that the new algorithm increased the number of effective satellite signals by 14%. In addition, the ERA5 data, the radiosonde data, and the COSMIC‐2 data were used as reference values. The accuracy of the water vapor density obtained by the algorithm was improved by 25%, 17% and 9%, respectively.
Preparation and characterization of TA surface modified HMX/F2602 composites
Authors: Xu Wenzheng , Zheng Xin , Wei Yamei , Tan Xianpeng , Wang Junyi , Yang Yulong , Zhao Leyang , Wang Jingyu 
Published: July 2023

AbstractEnhancing the safety performance of conventional polymer‐bonded explosives (PBX) has been a hot topic of research in the field of energy‐containing materials. For this purpose, this paper proposes a green and simple method to apply tannic acid (TA) to PBX by in situ polymerization. A two‐layer core‐shell composite with HMX as the core, TA as the inner shell, and fluoroelastomer F2602 as the outer shell was designed without changing the total binder content. The composites were analyzed by various tests and the goal of improving safety and mechanical strength was accomplished in the prepared TA‐modified PBX. Compared with the raw material HMX, the β‐δ phase transition temperature of PBX with double‐layer core‐shell structure is increased by 15.3 °C. In addition, the combination of TA coating and fluoropolymer allows the PBX to reduce impact and friction sensitivity. It also has excellent performance in enhancing the mechanical performance of PBX. The simplicity and scalability of the described method provide new ideas for the design and fabrication of high‐energy composites with higher safety and mechanical properties.
Impact of pomegranate juice on blood pressure: A systematic review and meta‐analysis
Authors: Ghaemi Fatemeh , Emadzadeh Maryam , Atkin Stephen L. , Jamialahmadi Tannaz , Zengin Gokhan , Sahebkar Amirhossein 
Published: July 2023

AbstractDespite the importance of polyphenol‐rich fruits in decreasing cardiovascular mortality, the impact of pomegranate juice (PJ) on blood pressure is still unclear. To determine the effect of PJ on blood pressure. PubMed, Scopus, ISI Web of Science, and Cochrane Library were searched comprehensively using relevant keywords. All studies using pomegranate juice alone were included although limited to human studies and the English language. A random‐effects model and the generic inverse variance approach were used to determine quantitative data synthesis. Meta‐analysis of 14 clinical trials (n = 573 individuals) demonstrated a reduction in systolic BP (SBP) with pomegranate juice (MD: −5.02 mmHg, 95% CI: −7.55 to −2.48, p < 0.001). Effect of study duration showed pomegranate juice intake ≤2 months significantly decreased SBP (MD: −4.59 mmHg, 95% CI: −7.10 to −2.08, p < 0.001) and DBP (MD: −2.94 mmHg, 95% CI: −5.25 to −0.63, p = 0.01). Consumption of ≤300 mL pomegranate juice daily reduced SBP (MD: −6.11 mmHg, 95% CI: −9.22 to −3.00, p < 0.001). Counterintuitively, >300 mL/day of pomegranate juice showed no effect on SBP (MD: −3.28 mmHg, 95% CI: −6.85 to 0.27, p = 0.07) but a significant DBP reduction occurred (MD: −3.10 mmHg, 95% CI: −5.74 to −0.47, p = 0.02). Meta‐regression showed that the SBP‐lowering effect of pomegranate juice was associated with the dose of supplementation (p < 0.001). Pomegranate juice appeared to decrease SBP and DBP in a dose‐dependent manner, but the benefit was lost after 2 months of pomegranate juice intake.
Suspected adverse reactions to medications and food supplements containing Serenoa repens: A worldwide analysis of pharmacovigilance and phytovigilance spontaneous reports
Authors: Crescioli Giada , Maggini Valentina , Raschi Emanuel , Gonella Laura Augusta , Luxi Nicoletta , Ippoliti Ilaria , Di Giovanni Valentina , Bonaiuti Roberto , Firenzuoli Niccolò , Gallo Eugenia , Menniti‐Ippolito Francesca , Moretti Ugo , Trifirò Gianluca , Vannacci Alfredo , Firenzuoli Fabio , Lombardi Niccolò 
Published: July 2023

AbstractThe safety of Serenoa repens (SR)‐containing products was evaluated conducting a retrospective worldwide analysis of pharmaco‐ and phytovigilance report forms of suspected adverse reactions (SARs) collected up to 31 January 2022. Multivariate logistic regression was performed to estimate the odds ratios (ORs) of serious SAR. A total of 1810 report forms were analysed; 92% of subjects were males, with a median age of 69 years; 44% of cases were defined as serious. Subjects exposed to dietary supplements had a higher risk of developing serious SARs (OR: 1.60 [95% CI: 1.20–2.15]), as subjects exposed to 2–5 (OR: 1. 83 [95% CI: 1.30–2.58]) or more than 5 (OR: 3.45 [95% CI: 2.36–5.06]) suspect/interacting products. The probability of experiencing serious SAR was higher for subjects exposed to concomitant products (OR: 1.55 [95% CI: 1.15–2.08]), to more than four active compounds (OR: 4.38 [95% CI: 3.21–5.99]) and to SR for more than 14 days (OR: 1.89 [95% CI: 1.10–3, 22]), and lower for subjects exposed to higher doses of SR (OR: of 0.34 [95% CI: 0.20–0.58]). This evidence improves awareness on safety of SR containing products, suggesting the need of a further update of periodic reviews by national and international regulatory agencies.
Strategies and software support for the management of hardware performance counters
Authors: Carnà Stefano , Marotta Romolo , Pellegrini Alessandro , Quaglia Francesco 
Published: July 2023

AbstractHardware performance counters (HPCs) are facilities offered by most off‐the‐shelf CPU architectures. They are a vital support to post‐mortem performance profiling and are exploited by standard tools such as Linux or Intel V‐Tune. Nevertheless, an increasing number of application domains (e.g., simulation, task‐based high‐performance computing, or cybersecurity) are exploiting them to perform different activities, such as self‐tuning, autonomic optimization, and/or system inspection. This repurposing of HPCs can be difficult, for example, because of the overhead for extracting relevant information. This overhead might render any online or self‐tuning activity ineffective. This article discusses various practical strategies to exploit HPCs beyond post‐mortem profiling, suitable for different application contexts. The presented strategies are accompanied by a general primer on HPCs usage on Linux. We also provide reference x86 (both Intel and AMD) implementations targeting the Linux kernel, upon which we present an experimental assessment of the viability of our proposals.
Staged‐construction analysis of high‐rise buildings: A literature review and future perspectives
Authors: Elansary Ahmed , Mabrouk Abdullah , El‐Attar Adel 
Published: July 2023

SummaryStaged‐construction analysis (SCA) has recently become a noticeable trend for estimating the design forces and deformations for high‐rise buildings (HRBs). SCA is a nonlinear step‐by‐step analysis that simulates the construction activities and conditions. It is a numerical simulation that considers loading history during construction, time‐dependent material behavior, environmental conditions, and any special measures taken by contractors to limit differential axial shortening during the construction process. However, building codes and guidelines do not provide adequate provisions that clearly identify how to approach this type of analysis. This paper presents a comprehensive state‐of‐the‐art review on how SCA was previously adopted in theoretical research and how it was applied in real buildings. It begins by critically reviewing different research work on SCA. Afterward, the paper puts forward the recent fundamentals of conducting SCA. Then, a series of studies about verifying SCA as practical analysis procedure using field measurements are then presented. In addition, the current paper reviews how SCA can specifically affect post‐tension slabs. Based on this review, several recommendations are provided to help in shaping the future code provisions, add to the development of recent practices, and inspire future research. The conducted review concludes that more investigations should be performed to better understand the effect of considering SCA on the deformations and design forces during HRB analysis.
Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors
Authors: Martins Leonardo , Amorim Weslley Wallace , Gregnani Marcos Fernandes , de Carvalho Araújo Ronaldo , Qadri Fatimunnisa , Bader Michael , Pesquero João Bosco 
Published: July 2023

Abstract
Objective and design
After traumatic skeletal muscle injury, muscle healing is often incomplete and produces extensive fibrosis. Bradykinin (BK) reduces fibrosis in renal and cardiac damage models through the B2 receptor. The B1 receptor expression is induced by damage, and blocking of the kallikrein-kinin system seems to affect the progression of muscular dystrophy. We hypothesized that both kinin B1 and B2 receptors could play a differential role after traumatic muscle injury, and the lack of the B1 receptor could produce more cellular and molecular substrates for myogenesis and fewer substrates for fibrosis, leading to better muscle healing.

Material and methods
To test this hypothesis, tibialis anterior muscles of kinin receptor knockout animals were subjected to traumatic injury. Myogenesis, angiogenesis, fibrosis, and muscle functioning were evaluated.

Results
Injured B1KO mice showed a faster healing progression of the injured area with a larger amount of central nucleated fiber post-injury when compared to control mice. In addition, they exhibited higher neovasculogenic capacity, maintaining optimal tissue perfusion for the post-injury phase; had higher amounts of myogenic markers with less inflammatory infiltrate and tissue destruction. This was followed by higher amounts of SMAD7 and lower amounts of p-SMAD2/3, which resulted in less fibrosis. In contrast, B2KO and B1B2KO mice showed more severe
tissue destruction and excessive fibrosis. B1KO animals had better results in post-injury functional tests compared to control animals.

Conclusions
We demonstrate that injured skeletal muscle tissues have a better repair capacity with less fibrosis in the presence of B2 receptor and absence of B1 receptor, including better performances in functional tests.
Novel insights into the nervous system affected by prolonged hyperglycemia
Authors: Zglejc-Waszak Kamila , Mukherjee Konark , Korytko Agnieszka , Lewczuk Bogdan , Pomianowski Andrzej , Wojtkiewicz Joanna , Banach Marta , Załęcki Michał , Nowicka Natalia , Jarosławska Julia , Kordas Bernard , Wąsowicz Krzysztof , Juranek Judyta K. 
Published: July 2023

Abstract
Multiple molecular pathways including the receptor for advanced glycation end-products-diaphanous related formin 1 (RAGE-Diaph1) signaling are known to play a role in diabetic peripheral neuropathy (DPN). Evidence suggests that neuropathological alterations in type 1 diabetic spinal cord may occur at the same time as or following peripheral nerve abnormalities. We demonstrated that DPN was associated with perturbations of RAGE-Diaph1 signaling pathway in peripheral nerve accompanied by widespread spinal cord molecular changes. More than 500 differentially expressed genes (DEGs) belonging to multiple functional pathways were identified in diabetic spinal cord and of those the most enriched was RAGE-Diaph1 related PI3K-Akt pathway. Only seven of spinal cord DEGs overlapped with DEGs from type 1 diabetic sciatic nerve and only a single gene cathepsin E (CTSE) was common for both type 1 and type 2 diabetic mice. In silico analysis suggests that molecular changes in spinal cord may act synergistically with RAGE-Diaph1 signaling axis in the peripheral nerve.

Key messages

Molecular perturbations in spinal cord may be involved in the progression of diabetic peripheral neuropathy.

Diabetic peripheral neuropathy was associated with perturbations of RAGE-Diaph1 signaling pathway in peripheral nerve accompanied by widespread spinal cord molecular changes.

In silico analysis revealed that PI3K-Akt signaling axis related to RAGE-Diaph1 was the most enriched biological pathway in diabetic spinal cord.

Cathepsin E may be the target molecular hub for intervention against diabetic peripheral neuropathy.
Topology optimization of microstructures with perturbation analysis and penalty methods
Authors: Li Bin , Zhuang Xiaoying , Fu Xiaolong , Rabczuk Timon 
Published: July 2023

AbstractTopology optimization at the continuum nano/microscale is of wide interest in designing and developing more efficient micro/nano electromechanical systems. This paper presents a new methodology for topology optimization of microstructures that is based on perturbation analysis and the penalty methods. The homogenized material coefficients are numerically computed based on perturbation analysis, and periodic boundary conditions are imposed by the penalty methods. The sensitivity analysis is implemented directly without the adjoint method. The extension of the proposed method to the design of components for multi-field analysis is straightforward. The capability and performance of the presented methodology are demonstrated through several numerical examples.