bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excision of mesenteric lymph nodes alters gut microbiota and impairs social dominance in adult mice
Authors: Yang Rui , Huang Bo‐Ya , Wang Yu‐Ning , Meng Qian , Guo Yi , Wang Shuang , Yin Xue‐Yong , Feng Hao , Gong Miao , Wang Sheng , Niu Chun‐Yu , Shi Yun , Shi Hai‐Shui 
Published: May 2023

IntroductionMesenteric lymph nodes (MLNs) are central in immune anatomy. MLNs are associated with the composition of gut microbiota, affecting the central system and immune system. Gut microbiota was found to differ among individuals of different social hierarchies. Nowadays, excision of MLNs is more frequently involved in gastrointestinal surgery; however, the potential side effects of excision of MLNs on social dominance are still unknown.MethodsMLNs were removed from male mice (7–8 weeks old). Four weeks after MLN removal, social dominance test was performed to investigate social dominance; hippocampal and serum interleukin (IL)‐1β, IL‐10, and tumor necrosis factor‐alpha (TNF‐α) were investigated; and histopathology was used to evaluate local inflammation of the ileum. The composition of the gut microbiota was then examined to understand the possible mechanism, and finally intraperitoneal injection of IL‐10 was used to validate the effect of IL‐10 on social dominance.ResultsThere was a decrease in social dominance in the operation group compared to the control group, as well as a decrease in serum and hippocampal IL‐10 levels, but no difference in serum and hippocampal IL‐1β and TNF‐α levels, and no local inflammation of the ileum after MLN removal. 16S rRNA sequencing analysis showed that the relative abundance of the class Clostridia was decreased in the operation group. This decrease was positively associated with serum IL‐10 levels. Furthermore, intraperitoneal injection of IL‐10 in a subset of mice increased social dominance.ConclusionsOur findings suggested that MLNs contributed to maintaining social dominance, which might be associated with reduced IL‐10 and the imbalance of specific flora in gut microbiota.
p‐Chloropropynyl Phenylalanine, a Versatile Non‐Canonical Amino Acid for Co‐Translational Peptide Macrocyclization and Side Chain Diversification
Authors: Osorio Franco H. Estheban , Le Anthony V. , Chang Nathan Y. , Hartman Matthew C. T. 
Published: May 2023

AbstractMacrocyclization has proven to be a beneficial strategy to improve upon some of the disadvantages of peptides as therapeutics. Nevertheless, many peptide cyclization strategies are not compatible with in vitro display technologies like mRNA display. Here we describe the novel amino acidp‐chloropropynyl phenylalanine (pCPF). pCPF is a substrate for a mutant phenylalanyl‐tRNA synthetase and its introduction into peptides via in vitro translation leads to spontaneous peptide macrocyclization in the presence of peptides containing cysteine. Macrocyclization occurs efficiently with a wide variety of ring sizes. Moreover, pCPF can be reacted with thiols after charging onto tRNA, enabling the testing of diverse ncAAs in translation. The versatility of pCPF should facilitate downstream studies of translation and enable the creation of novel macrocyclic peptide libraries.
Nivolumab‐induced fatal myocarditis: A case report
Authors: Bharathidasan Kavya , Abdelnabi Mahmoud , Abdelmalek John , Sekhon Jasmine , Butler William , Quirch Miguel , Sosa Erwin Argueta 
Published: May 2023

Key Clinical MessageBaseline assessment and interval monitoring with a careful history, clinical examination, laboratory work‐up, and noninvasive imaging modalities may be beneficial for early detection of immune checkpoint inhibitor‐associated side effects.AbstractPrevious reports of immune checkpoint inhibitors' cardiotoxic effects include pericarditis, myocarditis, myocardial infarction, ventricular dysfunction, vasculitis, and electrical abnormalities. The authors report a case of acute heart failure caused by nivolumab‐induced cardiotoxicity in a middle‐aged man with advanced esophageal carcinoma with no previous cardiac history or significant cardiovascular risk factors.
Phosphate‐functionalized Zirconium Metal–Organic Frameworks for Enhancing Lithium–Sulfur Battery Cycling
Authors: Liu Bingqian , Baumann Avery E. , Butala Megan M. , Thoi V. Sara 
Published: May 2023

AbstractLithium–sulfur batteries are promising candidates for next‐generation energy storage devices due to their outstanding theoretical energy density. However, they suffer from low sulfur utilization and poor cyclability, greatly limiting their practical implementation. Herein, we adopted a phosphate‐functionalized zirconium metal–organic framework (Zr‐MOF) as a sulfur host. With their porous structure, remarkable electrochemical stability, and synthetic versatility, Zr‐MOFs present great potential in preventing soluble polysulfides from leaching. Phosphate groups were introduced to the framework post‐synthetically since they have shown a strong affinity towards lithium polysulfides and an ability to facilitate Li ion transport. The successful incorporation of phosphate in MOF‐808 was demonstrated by a series of techniques including infrared spectroscopy, solid‐state nuclear magnetic resonance spectroscopy, and X‐ray pair distribution function analysis. When employed in batteries, phosphate‐functionalized Zr‐MOF (MOF‐808‐PO4) exhibits significantly enhanced sulfur utilization and ion diffusion compared to the parent framework, leading to higher capacity and rate capability. The improved capacity retention and inhibited self‐discharge rate also demonstrate effective polysulfide encapsulation utilizing MOF‐808‐PO4. Furthermore, we explored their potential towards high‐density batteries by examining the cycling performance at various sulfur loadings. Our approach to correlate structure with function using hybrid inorganic–organic materials offers new chemical design strategies for advancing battery materials.
Cascading failure invulnerability analysis of chemical material network considering failure propagation capability
Authors: Li Huapeng , Wang Zheng , Liu Ruijie , Hou Jingmin , Dong Zhaofei , Xie Tongtong 
Published: May 2023

AbstractThe material network in the chemical process has the characteristics of a complex network. Once the fault occurs, it will spread and lead to cascading failures, causing the chemical production process to not proceed normally. Previous studies of cascading failures have been limited by the size and characteristics of the network, which prevented the definition of the fault propagation capacity of the edge based on the actual situation. Studies on the effects of network topology and certain risk factors on the amount of fault propagation still need to be completed. Because of the above shortcomings, this study constructs a chemical material network cascading failure invulnerability analysis model that considers the failure propagation ability. Through the study of the chemical material network topology structure and the analysis of various flammable and explosive chemicals, the paper defines the fault propagation coefficient, which affects the load propagation quantity on the connecting edge. Then, based on the load‐capacity nonlinear cascading failure model, the chemical material network's invulnerability was analyzed by adjusting the model parameters. The effectiveness of the model is verified through case analysis. Compared to the existing model, the model in this paper effectively improves the invulnerability of the material network and can reduce the phenomenon of large‐scale failure of the material network due to the failure propagation capability is not considered.
Cryoablation inhibits the recurrence and progression of bladder cancer by enhancing tumour‐specific immunity
Authors: Mou Zezhong , Chen Yiling , Zhang Zheyu , Chen Xinan , Hu Yun , Zou Lujia , Xu Chenyang , Jiang Haowen 
Published: May 2023

AbstractBackgroundRecurrence and metastasis of bladder cancer are major factors affecting patient prognosis. Endoscopic cryoablation achieved a better clinical outcome among clinical patients and could be synergistic with ICIs. Thus, this study aimed to evaluate the immunological mechanism of cryoablation for bladder cancer to reveal the therapeutic mechanism.MethodsWe systematically reviewed the clinical prognosis of patients underwent cryoablation at Huashan Hospital in these first‐in‐human studies (ChiCTR‐INR‐17013060). Murine models were constructed to explore cryoablation‐induced tumour‐specific immunity, which was further confirmed by primary bladder tumour organoids and autologous lymphocytes cocultured system.ResultsCryoablation improved progression‐free survival and recurrence‐free survival respectively. Assessment of murine models after cryoablation confirmed microenvironment remodelling and tumour‐specific T cells expansion. Enhanced antitumour effects were found after coculture of organoids with autologous lymphocytes collected from post‐cryoablation. We also demonstrated cryoablation‐induced tumour elimination required IFNGR expression on tumour cells. In addition, a long‐lasting antitumour memory response is achieved by cryoablation and could be enhanced after combination with ICIs.ConclusionsThis study revealed endoscopic cryoablation is an efficient and safe therapy for bladder tumour treatment. The tumour‐specific immune responses induced by cryoablation could reduce tumour recurrence and metastasis.
Mineralogy, microstructures and geomechanics of rock salt for underground gas storage
Authors: Vandeginste Veerle , Ji Yukun , Buysschaert Frank , Anoyatis George 
Published: May 2023

AbstractRock salt has excellent properties for its use as underground leak‐proof containers for the storage of renewable energy. Salt solution mining has long been used for salt mining, and can now be employed in the construction of underground salt caverns for the storage of hydrogen gas. This paper presents a wide range of methods to study the mineralogy, geochemistry, microstructure and geomechanical characteristics of rock salt, which are important in the engineering of safe underground storage rock salt caverns. The mineralogical composition of rock salt varies and is linked to its depositional environment and diagenetic alterations. The microstructure in rock salt is related to cataclastic deformation, diffusive mass transfer and intracrystalline plastic deformation, which can then be associated with the macrostructural geomechanical behavior. Compared to other types of rock, rock salt exhibits creep at lower temperatures. This behavior can be divided into three phases based on the changes in strain with time. However, at very low effective confining pressure and high deviatoric stress, rock salt can exhibit dilatant behavior, where brittle deformation could compromise the safety of underground gas storage in rock salt caverns. The proposed review presents the impact of purity, geochemistry and water content of rock salt on its geomechanical behavior, and thus, on the safety of the caverns.
Investigating the potential of social media and citizen science data to track changes in species' distributions
Authors: O'Neill Daisy , Häkkinen Henry , Neumann Jessica , Shaffrey Len , Cheffings Chris , Norris Ken , Pettorelli Nathalie 
Published: May 2023

AbstractHow to best track species as they rapidly alter their distributions in response to climate change has become a key scientific priority. Information on species distributions is derived from biological records, which tend to be primarily sourced from traditional recording schemes, but increasingly also by citizen science initiatives and social media platforms, with biological recording having become more accessible to the general public. To date, however, our understanding of the respective potential of social media and citizen science to complement the information gathered by traditional recording schemes remains limited, particularly when it comes to tracking species on the move with climate change. To address this gap, we investigated how species occurrence observations vary between different sources and to what extent traditional, citizen science, and social media records are complementary, using the Banded Demoiselle (Calopteryx splendens) in Britain as a case study. Banded Demoiselle occurrences were extracted from citizen science initiatives (iRecord and iNaturalist) and social media platforms (Facebook, Flickr, and Twitter), and compared with traditional records primarily sourced from the British Dragonfly Society. Our results showed that species presence maps differ between record types, with 61% of the citizen science, 58% of the traditional, and 49% of the social media observations being unique to that data type. Banded Demoiselle habitat suitability maps differed most according to traditional and social media projections, with traditional and citizen science being the most consistent. We conclude that (i) social media records provide insights into the Banded Demoiselle distribution and habitat preference that are different from, and complementary to, the insights gathered from traditional recording schemes and citizen science initiatives; (ii) predicted habitat suitability maps that ignore information from social media records can substantially underestimate (by over 3500 km2 in the case of the Banded Demoiselle) potential suitable habitat availability.
Horizontal transmission of Salmonella Typhimurium among German cockroaches and its possible mechanisms
Authors: Mond Madison , Pietri Jose E. 
Published: May 2023

AbstractGerman cockroaches (Blattella germanica) can be both mechanical and biological (amplifying) vectors of enteric pathogens, including Salmonella enterica serovar Typhimurium (S. Typhimurium), which they acquire by feeding upon contaminated substances. Blattella germanica is also a gregarious species that shelters in groups and partakes in unique feeding behaviors such as conspecific coprophagy, necrophagy, and emetophagy. These properties create an interphase for potential horizontal transmission of pathogens among cockroach populations through the fecal‐oral route, which could in turn enhance transmission to humans and other animals. Here, we performed a series of experiments to determine: (1) whether horizontal transmission of S. Typhimurium infection takes place in B. germanica, (2) the prevalence of the phenomenon, and (3) the route(s) through which it may occur. We reveal that true horizontal transmission of S. Typhimurium occurs among B. germanica. That is, uninfected cockroaches acquire infection of the gut when co‐housed with orally infected conspecifics, albeit at low frequency. Furthermore, we provide definitive evidence that coprophagy and necrophagy are routes of transmission but could not exclude sharing of food or water as contributing routes. On the contrary, transmission by emetophagy appears less likely as oral regurgitates from infected cockroaches contained S. Typhimurium for less than one day after ingesting the bacteria. Together, our data enhance current understanding of the ecology of vector‐borne S. Typhimurium transmission by cockroaches, implicating conspecific horizontal transmission as a phenomenon that contributes to maintaining infected cockroach populations independently of contact with primary sources of the pathogen. Although the relative importance of horizontal transmission of pathogens in cockroaches in the field remains to be determined, these results also highlight the important role that food and water sources in the local environment may play in cockroach‐borne pathogen transmission and emphasize the importance of sanitation for not only abating infestations but also mitigating pathogen transmission.
The association between frailty and anxiety: A systematic review
Authors: Tan Melissa , Bhanu Cini , Frost Rachael 
Published: May 2023

AbstractObjectivesPrevious systematic reviews show a clear relationship between frailty and depression, however the association with anxiety is much less frequently explored. Previous single studies indicate evidence is mixed. We completed a systematic review and meta‐analysis to identify the relationship between frailty and anxiety.MethodsWe searched five electronic databases for observational studies in older people in community, care home and outpatient settings with any/no health conditions that measured the association between anxiety and frailty using validated measures. Studies were screened by one reviewer with 10% checked by a second reviewer. The Mixed Methods Appraisal Tool was used to assess study quality. We used meta‐analysis to aggregate study findings, with subgroup analyses to explore heterogeneity.ResultsOut of 1272 references, a total of 20 cross‐sectional and 1 longitudinal studies were eligible. Older adults with frailty were substantially more likely to display anxiety symptoms than robust populations, across both dichotomous and continuous data sets (n = 10, OR = 3.48, 95% CI: 2.08, 5.81, p < 0.0001, I2 = 94%; N = 5, SMD = 3.13, 95% CI: 1.06, 5.21, I2 = 98%). Similarly, pre‐frail older adults were more likely to have anxiety symptoms than robust older adults but to a lesser extent (N = 6, OR = 1.95, 95% CI: 1.41, 2.71, I2 = 63%; N = 3, SMD = 1.70, 95% CI: 0.01, 3.38, I2 = 98%).ConclusionsThere is a clear association between pre‐frailty/frailty and anxiety in older adults. However, data are heterogeneous and primarily from cross‐sectional studies so causality cannot be determined. Future research should evaluate the effectiveness of anxiety screening and treatments in frail older adults.
Regulation voltage of LiNiPO4 by density functional theory (DFT) calculation to move towards practical application
Authors: Zhang Bo , He Yufang , Wang Aiping , Xiao Xiang , Liu Jinli , Wu Yingqiang , Wang Li , Xu Hong , Li Jiangang , Zhang Hao , He Xiangming 
Published: May 2023

AbstractLiNiPO4 (working at ~5.1 V) shows potential advantages in the competition of cathode materials for lithium‐ion batteries (LIBs) because of high energy density. However, the high‐voltage electrolyte developed can only remain relatively stable in the range of less than 4.8 V, so the operating voltage of LiNiPO4 needs to be adjusted to smaller to better exploit its high‐voltage advantages. To regulate the operating voltage of LiNiPO4 while ensuring the relative stability of its electrochemical properties, in this work, all the 3d, 4d, and 5d transition metals (TMs) are, respectively, doped into the Ni site of LiNiPO4 to screen out the doped models with excellent electrochemical performance. In particular, the changes in lattice structure, electronic properties, formation energy, mechanical properties, anisotropy, and working voltage were used as screening criteria. By considering the above screening criteria, the Cr‐ and Fe‐doped LiNiPO4 with open circuit voltage ~4.7 and ~4.8 V are considered to have leading performance and can be used for applicable high‐voltage LIBs. The screening results of this work can provide an overall understanding of the doping of LiNiPO4 by TMs and have advanced a theoretical idea for the design of new high‐voltage LIBs cathode materials.
Fullerene modification of WO3 electron transport layer toward high‐efficiency MA‐free perovskite solar cells with eliminated light‐soaking effect
Authors: Yu Xin , Cai Bing , Zhang Jinxia , Li Xingcheng , Wang Xue , Duan Gongtao , Zhang Wenfeng , Liu Xinhang , Zhang Wen‐Hua , Yang Shangfeng 
Published: May 2023

AbstractIn perovskite solar cells (PSCs), the light‐soaking effect, which means device performance changes obviously under continuous light illumination, is potentially harmful to loaded devices as well as accurately assessing their efficiency. Herein, chemically stable tungsten trioxide (WO3) with high electron mobility is used as electron transport material in methylamine (MA)‐free PSCs. However, the light‐soaking effect is observed apparently in our devices. A fullerene derivative, C60 pyrrolidine Tris‐acid (CPTA), is introduced to modify the interface between WO3 and perovskite (PVK) layers, which can bond with WO3 and PVK simultaneously, leading to the passivation of the defect and the suppression of trap‐assisted nonradiative recombination. What is more, the introduction of CPTA can enhance the built‐in electric field between WO3 and PVK layers, thereby facilitating the electron extraction and inhibiting the carrier accumulation at the interface. Consequently, the light‐soaking effect of WO3‐based PSCs has been eliminated, and the power conversion efficiency has been boosted from 17.4% for control device to 20.5% for WO3/CPTA‐based PSC with enhanced stability. This study gives guidance for the design of interfacial molecules to eliminate the light‐soaking effect.
A comparison of peripheral blood stem cell collection outcomes for multiple myeloma; mobilization matters in the era of IMiD induction
Authors: Chandler Thea , Parrish Christopher , Karakantza Marina , Carmichael Jonathan , Pawson David , Cook Gordon , Seymour Frances 
Published: May 2023

AbstractCollection of peripheral blood stem cells (PBSCs) for autologous stem cell transplant (ASCT) requires mobilization from the bone marrow. There is variation in mobilization choice; during the COVID‐19 pandemic BSBMT&CT guidelines recommended using granulocyte‐colony stimulating factor (G‐CSF) alone to minimize the use of chemotherapy. We report on the impact of mobilization regimen on stem cell collection, and whether IMiD‐containing induction therapy impacts on mobilization and consequently transplant engraftment times for 83 patients undergoing ASCT at Leeds Teaching Hospitals.Cyclophosphamide plus G‐CSF (cyclo‐G) mobilization yielded more CD34+ cells (8.94 vs. 4.88 ×106/kg, p = < 0.0001) over fewer days (1.6 vs. 2.4 days, p = 0.007), and required fewer doses of salvage Plerixafor than G‐CSF only (13.6% vs. 35%, p = 0.0407). IMiD‐containing induction impaired all of these factors. CD34+ doses > 8×106/kg were more frequent with Cyclo‐G (62% vs. 11%, p = 0.0001), including for those receiving IMiD 1st line induction (50% vs. 13.3%, p = 0.0381). Note that 92.6% of those receiving IMiD‐free inductions were mobilized with Cyclo‐G.The novel agents used in modern induction regimens (e.g Daratumumab) have been shown to impair yields, increasing the importance of optimizing mobilization regimens in the first instance. Furthermore, as cellular therapies become established in the management of multiple myeloma emerging data highlights the potential benefits of stem cell top up in the management of the haematological toxicities of these therapies. Our findings support re‐adoption of Cyclo‐G as the gold standard for mobilization to optimize PBSC harvesting and ensure sufficient cells for subsequent ASCTs.