bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENETAPAN UPAH KARYAWAN BERDASARKAN BESARNYA LABA PENJUALAN
Authors: Sonia Tara , Atika Atika , Napisah Napisah 
Published: September 2023

ABSTRAK

Hasil penelitian menyimpulkan bahwa (1) Perjanjian penetapan upah karyawan berdasarkan besarnya laba penjualan di Toko Herbal Uncle Udin Palembang adalah dikaitkan dengan Undang-Undang Nomor 11 Tahun 2020 tentang Cipta Kerja yang diatur di dalam Pasal 81 angka 28 yang memuat baru Pasal 90B Undang-Undang Nomor 13 Tahun 2003 bahwa pemilik kerja termasuk ke dalam pengecualian bagi pengusaha yang menerapkan ketentuan upah minimum dalam membayar upah karyawannya. Karena Toko Herbal Uncle Udin Palembang termasuk ke dalam usaha mikro dan kecil yang mana di dalam Undang-Undang tersebut memberikan pengecualian di dalam membayar upah karyawan berdasarkan ketentuan upah minimum. Maka upah karyawan pada usaha mikro dan kecil dapat dibayarkan berdasarkan kesepakatan antara pengusaha dan pekerja di perusahaan. (2) Dalam tinjauan Hukum Ekonomi Syari’ah bahwasanya Toko Herbal Uncle Udin Palembang telah sesuai dengan rukun dan syarat ujrah dan diperbolehkan bagi pemilik toko menetapkan upah karyawan berdasarkan besarnya laba penjualan karena telah sesuai berdasarkan prinsip keadilan, prinsip keterbukaan dan prinsip kemaslahatan. Metode penelitian yang digunakan adalah penelitian lapangan atau (Field Research) dengan menggunakan Social Situation sebagai populasi penelitian dan teknik sampling dengan cara probability sampling
Kata Kunci : Perjanjian, Penetapan Upah, Laba Penjualan
Pharmacoepidemiological analysis of therapy for chronic heart failure
Authors: Monakhova D. D. , Shchegoleva V. A. , Spiridonova T. I. 
Published: September 2023

The aim of the study was to examine the schemes proposed in the clinical guidelines and to compare them with inpatient treatment methods.Materials and method, the case histories of 40 patients of cardiology department of Saratov medical preventive institution were analyzed. Men and women, aged from 50 to 80 years, with functional class (FC) II to IV, with reduced left ventricular ejection fraction (< 40 %) and with such diseases in anamnesis as arterial hypertension, coronary heart disease, atherosclerosis, diabetes mellitus were in the inclusion group. The exclusion group included patients with noncardiac diseases, pediatric patients, patients under 50 and over 80 years old, patients with I class, preserved and intermediate LV ejection fraction (> 40 %). The results of immunochromatographic analysis of NT-proBNP marker were studied, the identity of prescribed drugs to a certain group and their frequency of use, as well as the similarity of prescribed regimen to clinical guidelines were determined.Results. NT-proBNP level over 125 pg/ml was revealed in 21 out of 40 patients, arterial hypertension, atherosclerosis, ischemic heart disease were in the anamnesis testifying to high probability of CHF. Perindopril (80 %) and fosinopril (20 %) were the main angiotensin-converting enzyme inhibitors (ACEIs). Spironolactone (a К + -saving diuretic), thorasemide, furosemide (a loop diuretic) and indapamide (a thiazide-like diuretic) were used as diuretics. Among blockers, metoprolol (20 %), nebivolol (30 %), bisoprolol (50 %) were prescribed. Patients suffering from CHF and with a history of atherosclerosis were prescribed statins (rosuvastatin, atorvastatin) in addition to the main groups of drugs in all cases. Warfarin (9.5 %) and rivaroxaban (23.8 %) were present in 7 of 21 cases (33 %). In addition, 17 patients (81 %) were prescribed acetylsalicylic acid as an antiaggregant. Those with a history of diabetes mellitus (19 %) received metformin for glycaemic control, as an adjunctive therapy to the main combinations of drugs.Conclusions. The inpatient regimen used to treat patients with CHF is more in line with the clinical guidelines.
Coronary artery transplantation operations (review)
Authors: Morozov A. M. , Sergeev A. N. , Askerov E. M. , Kadykov V. A. , Alieva T. S. , Fisyuk E. A. 
Published: September 2023

Relevance. Coronary artery transplantation operations are an effective method for the treatment of developmental anomalies and pathologies of the coronary arteries, which lead to a cascade of negative consequences. Pathologically altered coronary arteries cannot fully function normally and this condition leads to myocardial ischemia. Ischemic heart disease (CHD) is a chronic inflammatory disease that quickly leads to functional disorders in the body. CHD is mainly caused by atherosclerosis of the arteries and is the leading cause of death in most developed countries.The purpose of study. To study the operational possibilities of coronary artery transplantation.Materials and methods. In the course of this study, a review of foreign literature on the problem of surgical interventions on the coronary arteries was carried out, in addition, data from randomized controlled trials and controlled clinical trials were analyzed, which reported on various approaches to the treatment of pathologies of the heart vessels.Results. Coronary artery bypass grafting is most often performed in coronary heart disease caused by a sharp narrowing or occlusion of the lumen of the coronary artery. Coronary artery bypass grafting (CABG) is a major surgical operation, which consists in restoring blood circulation bypassing the stenotic area of the coronary artery using venous or arterial bypasses (grafts). At the same time, blood flow to the ischemic myocardium is restored, which leads to the restoration of the function and viability of the heart muscle. Coronary artery bypass grafting, as mentioned above, is a frequently performed surgical intervention, with almost 400,000 CABG surgeries performed annually, which proves its effectiveness in the treatment of coronary artery disease.Conclusion. This study proves the importance of coronary artery transplantation in the treatment of pathologies and anomalies of the arteries of the heart. There are several types of surgical interventions, and therefore it is necessary to approach each individual case individually and find the optimal solution. An important role in preventing postoperative complications and sudden cardiac arrest is played by careful preoperative diagnostics, including coronary angiography, echocardiography, computed tomography, and other methods. With careful preoperative diagnosis, a well-chosen operation strategy and postoperative prevention, it is possible to avoid repeated cardiac revascularization and achieve complete recovery of the patient with no complications for decades.
The possibilities of machine learning in determining the variants of the course of viral pneumonia associated with COVID-19 based on computed tomography data
Authors: Skorobogach I. M. , Khamidova L. T. , Muslimov R. S. , Rybalko N. V. , Petrikov S. S. 
Published: September 2023

Introduction. In acute COVID-19 respiratory infection caused by SARS-CoV-2 coronavirus (2019-nCov), lung damage has a different course, which has not been studied so far. The purpose of the study. To study the variants of the course of COVID-19 viral pneumonia (VP) based on the analysis of the dynamics of lung damage, quantified by computed tomography.Material and methods. Quantitative analysis of computed tomography (CT) data of the chest of 144 patients with VP was performed using the 3D Slicer software application. Cluster and comparative nonparametric analyses of the severity of lung damage (CT1, CT2, СТЗ, CT4) and the total volume of affected lungs (%) obtained during primary and two repeated CT studies (pCT, 1dCT and 2dCT) in the program "Statistica 12" were carried out.Results. With a stable course, the total volume of the affected lungs is constant, within one degree of severity: CT1 - in 23.6 %, CT2 - in 14.6 %, CT3 - in 5.6 %, CT4 - in 8.3 %. With a progressive course, the volume of lung damage gradually increases from minimum to maximum CT1-CT2-CT3 in 3.5 %, or increases to the maximum level on the second CT, remaining stable on the third study (CT2-CT3-CT3) - in 4.2 %. With a regredient course, the volume of lung damage varies from the maximum at the primary examination (pCT) to the minimum at the third (2dCT): gradually from CT4 through CT3 to CT2 in 4.2 %, or by one degree of severity CT3-CT2-CT2 in 9.7 %, CT3-CT3-CT2 in 9.0 %. With a progressive-regredient course, the volume of lung damage first reaches a maximum on 1dCT, a minimum on 2dCT - CT2-CT3-CT2 - in 17.4 %. An intragroup comparison of three repeated, dependent indicators of the total volume of the affected lungs and an intergroup comparison on pCT, 1dCT and 2dCT showed a dynamic statistically significant difference between them for variants of the course of VP (p < 0.05).Conclusions. Cluster analysis of the total volume of affected lungs on a series of three CT studies in dynamics allowed us to identify 5 variants of the course of COVID-19 - stable - light, stable-severe, progressive, regredient, progressive-regredient.
Single-phase grounding line selection method for closed-loop distribution network adapted to medium voltage microgrid access
Authors: Lu Qinghui , Yin Xiang-Gen , Qiao Jian , Liu Zhichang , Zhu Lingjin , Yin Xin 
Published: September 2023

Aim: The access of the medium-voltage (MV) microgrid changes the radial structure of traditional distribution networks, causing the distribution network to operate in a closed-loop manner. The closed-loop operation complicates the fault characteristics of the distribution network, and the traditional single-phase grounding (SPG) line selection method is no longer applicable. Therefore, it is necessary to propose a new targeted SPG line selection method.
Methods: This paper analyzes the network structure of MV microgrids and MV distribution networks and establishes a multi-level closed-loop operation distribution network model with MV microgrid access. Then, the SPG fault characteristics of the closed-loop operation distribution system under the small current grounding mode are analyzed from the perspective of two-level bus nodes. Furthermore, based on the analysis of fault characteristics, a closed-loop operation distribution network line selection method suitable for microgrid access is proposed, and a detailed design is carried out in terms of equipment configuration and communication schemes, forming a relatively complete automatic line selection system. At the same time, the proposed line selection scheme is based on the two-level bus nodes, which can be analogously applied to the multi-level closed-loop operation distribution network.
Results: The simulation results show that the proposed line selection scheme can be effectively applied to the closed-loop operation distribution network with MV microgrid access.
Conclusion: The traditional SPG line selection method will have misjudgment problems after the MV microgrid is integrated into the distribution network, but the line selection method proposed in this paper has good adaptability.
Respon Tanaman Pakcoy (Brassica Rapa L.) Terhadap Pemberian Kompos Limbah Ekstraksi Minyak Atsiri Pada Tanah Ultisol
Authors: Noorhidayah Ratri , Sari Sinthia Ringga , Maryanto Joko , Widyasunu Purwandaru 
Published: September 2023

Penelitian ini dilaksanakan untuk: 1) mengetahui pengaruh pemberian kompos yang berasal dari limbah ekstraksi minyak atsiri terhadap pertumbuhan dan hasil tanaman pakcoy pada Ultisol, 2) mengetahui lama waktu inkubasi pupuk yang tepat untuk pertumbuhan dan hasil tanaman pakcoy, dan mengetahui jenis kompos dari jenis limbah minyak atsiri yang paling baik untuk pertumbuhan tanaman pakcoy pada Ultisol. Penelitian dilaksanakan pada bulan Januari sampai dengan April 2020 di screen house yang bertempat di Dusun II, Kebanggan, Kecamatan Sumbang, Kabupaten Banyumas dan Laboratorium Ilmu Tanah, Fakultas Pertanian Universitas Jenderal Soedirman. Rancangan percobaan yang digunakan yaitu Rancangan Acak Kelompok Lengkap (RAKL) pola faktorial dengan 2 faktor, yaitu dengan faktor pupuk kompos limbah ekstraksi minyak atsiri yang terdiri dari kontrol (tanpa pemberian pupuk), pupuk kompos dari limbah ekstraksi biji kakao, tanaman kemukus, akar tanaman akar wangi, biji tanaman kopi, rimpang tanaman jahe, dan endapan IPAL (Instalasi Pengolahan Air Limbah). Faktor yang kedua yaitu lama inkubasi kompos yang terdiri dari 4 dan 8 minggu. Variabel yang diamati yaitu tinggi tanaman, jumlah daun, luas daun, bobot tanaman segar, bobot akar segar, dan bobot tanaman kering. Hasil penelitian menunjukkan pemberian pupuk kompos ekstraksi limbah minyak atsiri dari tanaman kakao memberikan hasil tertinggi pada variabel tinggi tanaman (21 cm), jumlah daun (14,50 helai), luas daun (1425 cm2), bobot tanaman segar (73,35 g), bobot segar akar (7,03 g) dan bobot tanaman kering (5,05 g). Perlakuan inkubasi selama 4 minggu memberikan hasil yang tertinggi pada variabel tinggi tanaman (17,83 cm) dan jumlah daun (12,52 helai). Perlakuan lama waktu inkubasi dengan waktu 8 minggu menghasilkan nilai tertinggi pada variabel luas daun (900,35 cm2), bobot tanaman segar (42,96 g), bobot tanaman kering (4,97) dan bobot tanaman kering (3,24 g. pemberian pupuk organik limbah ekstraksi minyak atsiri dan lama inkubasi pada variabel tinggi tanaman, memberikan pengaruh yang nyata terhadap bobot tanaman segar dan bobot tanaman kering. Sedangkan untuk variabel jumlah daun, luas dau dan bobot segar agar tidak terdapat interaksi dari pemberian pupuk organik limbah ekstraksi minyak atsiri dan lama inkubasi pupuk.
Cultivated Land Green Use Efficiency and Its Influencing Factors: A Case Study of 39 Cities in the Yangtze River Basin of China
Authors: Lin Qiaowen , Bai Siran , Qi Rui 
Published: September 2023

In recent years, the Chinese government pays more and more attention to agricultural development and ecological protection. While improving the cultivated land green use efficiency(CLGUE) is the key to promote the sustainable development of agriculture. This study aims to study the current situation and influencing factors of agricultural production from the perspective of green utilization efficiency of cultivated land. It takes 39 cities in the upper, middle and lower reaches of the Yangtze River basin in China as an example. The CLGUE values in those 39 cities from 2011 to 2020 were specifically measured, using the Super-SBM model, kernel density estimation and geographic detector method. Their temporal and spatial heterogeneity was described, and the influencing factors were detected at both single and interactive levels. The results showed that: （1）From 2011 to 2020, the green utilization efficiency value of cultivated land in the Yangtze River Basin showed an upward trend on the whole; （2）There is a clear spatial heterogeneity the CLGUE values in the Yangtze River Basin cities, as shown by: downstream region &gt; midstream region &gt; upstream region; (3) Cultivated land resource endowment, socioeconomic development, and agricultural production technology are important factors affecting the variability of CLGUE values. However, there are some differences in the degree and direction of influence of different influencing factors on different sample subgroups.
Trends of the development of unit investment funds under sanctions
Authors: Gafurova G. T. , Notfullina G. N. , Kovaleva E. R. 
Published: September 2023

Objective: to identify promising areas of research, limitations and factors of UIF market development in order to elaborate methodological recommendations for the management of UIF assets.Methods: content analysis and systematization of materials published in scientific journals and analytical publications; review of scientific literature, vertical and horizontal analysis, trend and coefficient analysis, correlation and regression analysis. Results: the development of the collective investment institution in Russia is characterized by certain features. Despite difficult economic and geopolitical conditions of the recent years, retail investors show considerable interest in unit funds. Against the background of COVID restrictions, active development of remote services, and aggressive marketing of management companies, the number of shareholders has increased significantly. The paper analyzes the main trends in the development of UIF market in 2018-2022; the main factors of the development of collective investments are formulated. It was determined that the key factors hindering the development of this market are the low level of financial literacy of retail investors, the poor quality of UIF portfolio management, leading to losses for unit holders, and the increased risks as a result of the sanctions burden on the Russian financial market. Based on the study results, the basic recommendations are formulated that may contribute to the development of the market and improve the quality of managing the assets of unit holders.Scientific novelty: a review of research on the unit funds effectiveness was conducted, as a result of which it was determined that research on the collective investment market as such is poorly represented, and the problems of the market efficiency under sanctions are not considered. The main challenges and limitations of the collective investment institution development under the current economic conditions are formulated: (1) digitalization of the financial sector, (2) blocking of foreign assets, (3) low level of financial literacy of the population. Recommendations were made for the UIF market development:(1) legal regulation of the transparency of funds, (2) creation of a system of assignment of claims on the unit holders’ assets, (3) creation of a system of remuneration for the UIF success with active investment strategies strategies.Practical significance: the main results of the work can be used in the practical activities of managing companies in the management of unit investment funds under uncertainty of the environment.
Microbial production of the plant flavanone hesperetin from caffeic acid
Authors: Hanko Erik K. R. , Correia João , Souza Caio S. , Green Alison , Chromy Jakub , Stoney Ruth , Yan Cunyu , Takano Eriko , Lousa Diana , Soares Cláudio M. , Breitling Rainer 
Published: September 2023

Abstract
Objective
Hesperetin is an important O-methylated flavonoid produced by citrus fruits and of potential pharmaceutical relevance. The microbial biosynthesis of hesperetin could be a viable alternative to plant extraction, as plant extracts often yield complex mixtures of different flavonoids making it challenging to isolate pure compounds. In this study, hesperetin was produced from caffeic acid in the microbial host Escherichia coli. We combined a previously optimised pathway for the biosynthesis of the intermediate flavanone eriodictyol with a combinatorial library of plasmids expressing three candidate flavonoid O-methyltransferases. Moreover, we endeavoured to improve the position specificity of CCoAOMT7, a flavonoid O-methyltransferase from Arabidopsis thaliana that has been demonstrated to O-methylate eriodictyol in both the para- and meta-position, thus leading to a mixture of hesperetin and homoeriodictyol.
Results
The best performing flavonoid O-methyltransferase in our screen was found to be CCoAOMT7, which could produce up to 48.4 µM hesperetin and 12.7 µM homoeriodictyol from 3 mM caffeic acid in E. coli 5-alpha. Using a platform for enzyme engineering that scans the mutational space of selected key positions, predicting their structures using homology modelling and inferring their potential catalytic improvement using docking simulations, we were able to identify a CCoAOMT7 mutant with a two-fold higher position specificity for hesperetin. The mutant’s catalytic activity, however, was considerably diminished. Our findings suggest that hesperetin can be created from central carbon metabolism in E. coli following the introduction of a caffeic acid biosynthesis pathway.
Association Between Traditional Chinese Medicine and Medication Adherence in Hypertensive Patients in Mainland China: A Real-World Population-Based Cohort Study
Authors: Zhou Jifang , Shang Lili , Bao Yuqing , Cheng Yan , Huang Ruijian , Kong Desong , Gu Ning , Ma Aixia 
Published: September 2023

Abstract
Background: Hypertension and associated CVD are the major public health challenges in China. Medication adherence is the cornerstone for achieving hypertension control and reduce the risk of CVD and mortality. Considering that more and more people have turned on complementary and alternative medicine(CAM) , combined with pharmacotherapy for treating hypertension, including Traditional Chinese Medicine(TCM).However, the relationship between medication adherence and TCM usage remains unknown. This study aimed to assess the association between non-pharmacological therapies of TCM and adherence to anti-hypertensive medication in mainland China.
Methods: Data was extracted from the electronic health records of a Chinese medical hospital. A retrospective cohort study was conducted on hypertension patients enrolled between January 2016 and April 2021. Propensity score matching (PSM) was employed, resulting in 1179 patients in the TCM user group and 257 patients in the no TCM user group. Medication possession ratios (MPR) were used to measure medication adherence in the presence or absence of TCM. Generalized estimating equations (GEE) were applied to identify factors associated with adherence, including TCM exposure, age and sex.
Results: Medication compliance in the real world was generally low, at approximately 10%. The percentage of TCM exposure among differed significantly between the two groups throughout the follow-up period. The proportions of optimal adherence (MPR≥ 80) and continuous treatment rate showed no significant difference. GEE regression results indicated that TCM visits could improve medication adherence to anti-hypertensive drugs. Subgroup analysis revealed that TCM use had a positive impact on optimal adherence for male patients and patients aged 60 years and above (p<0.05). Conversely, there was no association between TCM use and MPR in female patients.
Conclusions: Notably, medication compliance was higher among TCM users compared to no TCM users. TCM exposure appeared to have a positive effect on medication adherence in hypertensive patients, suggesting its potential as a complementary approach to conventional Western drug therapy. This study provides important insights for integrating Chinese and Western medicine to enhance adherence to anti-hypertensive medications.
BiœmuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic Spiking Neural Network
Authors: Levi Timothee , Beaubois Romain , Cheslet Jérémy , Duenki Tomoya , Khoyratee Farad , Branchereau Pascal , Ikeuchi Yoshiho 
Published: September 2023

Abstract

Characterization and modeling of biological neural networks is a field opening to major advances in our understanding of the mechanisms governing the functioning of the brain and the different pathologies that can affect it. Recent researches in bioelectronics and neuromorphic engineering lead to the design of the new generation of neuroprosthesis. Here we show a novel real-time, biomimetic and energy-efficient neural network for bio-hybrid experiments and parallel emulation. This novel system is used to investigate and reproduce neural network dynamics. The setup is running on a digital platform using a System on Chip (SoC) featuring both Programmable Logic (PL) and processors in a Processing System (PS) part. The FPGA part is computing the biomimetic and real-time electrical activities of Hodgkin-Huxley neural network while the processors handle monitoring and communication. New methods of resource and power optimization has been applied to the FPGA to allow detailed neuron modeling with synapses showing short term plasticity. The system is validated by comparison with biological data and model. We also demonstrate the feasibility of bio-hybrid experiments with different bio-physical interface and different biological cells. The complete setup achieves communication with a fully flexible real-time device thus constituting a step towards neuromorphic-based neuroprosthesis for bioelectrical therapeutics.