bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forecasting China’s marine scientific research and education, marine industrial structure upgrading and marine economy growth based on the AWBO-MGM(1,m) model
Authors: Xu Haojun , Li Na 
Published: July 2023

PurposeThe purpose of this paper is to explore the internal interaction mechanism of marine scientific research and education, industrial structure upgrading and marine economic growth from a systematic perspective, based on which this work forecasts their future development trends.Design/methodology/approachIn this study, a multivariate grey model is applied to the prediction of marine scientific research and education, industrial structure upgrading and marine economic growth. Considering the impact of the COVID-19 on marine development, this paper introduces the weakening buffer operator into MGM(1,m) and constructs the AWBO-MGM(1,m) model. To verify the validity and accuracy of the new model, this paper uses AWBO-MGM(1,m), MGM(1,m), GM(1,N), GM(1,1), back propagation neural network and linear regression models for simulation and prediction based on the data from 2010 to 2021, respectively.FindingsFrom the theoretical perspective, the development of marine scientific research and education can accelerate industrial upgrading and promote marine economic growth by providing high-quality talents, promoting marine science and technology progress and reducing transaction costs; while the upgrading of marine industrial structure and marine economic growth can promote the development of marine scientific research and education by guiding social capital, enhancing talent demand and stimulating market vitality. From the empirical analysis, the AWBO-MGM(1,m) model can effectively deal with epidemic shocks and has higher fitting and prediction accuracy than the other five comparative models.Practical implicationsThe government should pay attention to the construction of marine scientific research and education, so as to provide high-quality talents and advanced scientific research results for the high-quality development of marine economy. On the basis of using science and technology to firmly build the primary and secondary marine industries, the government should actively guide the labor, capital and other factors of production to the tertiary industry, thereby promoting the optimization and upgrading of marine industrial structure.Originality/valueOn the one hand, the interplay mechanism of marine scientific research and education, industrial structure upgrading and marine economic growth is analyzed from a systematic perspective; on the other hand, the enhanced AWBO-MGM(1,m) possesses higher forecasting performance and is applicable to the systemic multivariate forecasting problem in the presence of outstanding external shocks.
Post-COVID assessment of small business weavers in an Indian handloom industry: identifying and prioritizing key challenges
Authors: Naik M.K.P. , Bhardwaj Prabhas , Mishra Vinaytosh 
Published: July 2023

Purpose
This paper aims to identify and analyze the challenges for the Varanasi handloom industry after the COVID pandemic by considering their impact on different sections of the weavers and subsequently suggest the best possible solution for the same.

Design/methodology/approach
A combined approach of expert opinion and in-depth literature reviews are used to identify the challenges, and a multicriteria decision-making tool is used to rank the challenges for the type of weaver.

Findings
This research provides an elaborated view of the problems faced by the handloom industry after the COVID pandemic and suggests that the success of the handloom business is subjected to the eradication of a wide number of challenges according to the type of weaver.

Practical implications
The findings of this research will help the policymakers to make and align their policies and strategies for the upliftment of the Varanasi handloom industry efficiently and effectively.

Originality/value
To the best of the authors’ knowledge, this is the first kind of study that focuses on identifying and prioritizing the barriers affecting the success of the Varanasi handloom industry after the COVID pandemic. Furthermore, the uniqueness of this research lies in its ability to study all three independent sections of the handloom industry, having different capabilities and limitations.
Xoxoday – growth in the post-COVID world
Authors: Gupta Pooja , Dutta Gupta Sangita , Garg Varnika , Jain Aakriti , Kavalakkatt John , Mahawar Aditi 
Published: July 2023

Theoretical basis
There are two theoretical concepts that can be taught in this case.The new approach to teaching entrepreneurship is termed “lean start-up” and “hypothesis-driven entrepreneurship.” The business model canvas is a core tool of this approach. This framework defines nine key components of a successful business strategy. These components include defining value propositions; identifying customer segments; identifying channels; maintaining customer relationships; defining key activities, key resources and key partners; understanding the revenue model of the business; and the organization’s cost structure. This is considered to be a rigorous approach to learning about and developing a new venture.The other theoretical approach that can be discussed through this case is the link between uncertainty and entrepreneurial growth. These theories associate the willingness of entrepreneurs to bear the perceived uncertainty associated with entrepreneurial acts as representative of the belief-desire model. There is a need for entrepreneurs to experiment and search for alternative paths forward in order to counter this uncertainty. Systematic search processes to discover relevant information will strengthen this process.

Research methodology
This case is based on primary data collected through interviews with company personnel. The company consented freely to the use of their data in the case. The authors have no connection with the company. The four student coauthors had previously pursued an internship with the company and had worked on the machine learning analysis part.The two faculty coauthors in the case contacted the company after the internship and discussed the opportunity to write the case on the company. One of the faculty then interviewed key personnel in the company, including one of the co-founders.

Case overview/synopsis
Xoxoday is a technology company that provides employee rewards and corporate gifting to its customers. The company was started by Sumit Khandelwal, Manoj Agarwal, Abhishek Kumar and Kushal Agarwal. In 2018, the company reinvented itself as an experiential gifting company.The company faced some challenges during the lockdowns imposed due to COVID-19. Khandelwal knew that they had to try something new to achieve higher growth in the future. He wondered if higher usage of technology was the solution. It was necessary for them to carve a new path in these times.

Complexity academic level
This case study can be used at the undergraduate level in courses relating to entrepreneurship strategy and business models for entrepreneurs.The case can be used to highlight the dilemmas faced by entrepreneurs due to unforeseen crises. This case is relevant for classes that will discuss growth crises and out-of-the-box solutions for unprecedented crisis situations.
Coupling the electrocatalytic dechlorination of 2,4‐D with electroactive microbial anodes
Authors: Leon‐Fernandez Luis F. , Dominguez‐Benetton Xochitl , Villaseñor Camacho José , Fernandez‐Morales Francisco Jesús 
Published: July 2023

AbstractThis work proves the feasibility of dechlorinating 2,4‐D, a customary commercial herbicide, using cathodic electrocatalysis driven by the anodic microbial electrooxidation of sodium acetate. A set of microbial electrochemical systems (MES) were run under two different operating modes, namely microbial fuel cell (MFC) mode, with an external resistance of 120 Ω, or microbial electrolysis cell (MEC) mode, by supplying external voltage (0.6 V) for promoting the (bio)electrochemical reactions taking place. When operating the MES as an MFC, 32% dechlorination was obtained after 72 h of treatment, which was further enhanced by working under MEC mode and achieving a 79% dechlorination. In addition, the biodegradability (expressed as the ratio BOD/COD) of the synthetic polluted wastewater was tested prior and after the MES treatment, which was improved from negative values (corresponding to toxic effluents) up to 0.135 in the MFC and 0.453 in the MEC. Our MES approach proves to be a favourable option from the point of view of energy consumption. Running the system under MFC mode allowed to co‐generate energy along the dechlorination process (−0.0120 kWh mol−1), even though low removal rates were attained. The energy input under MEC operation was 1.03 kWh mol−1—a competitive value compared to previous works reported in the literature for (non‐biological) electrochemical reactors for 2,4‐D electrodechlorination.
Addiction: A treatise from 1561
Authors: Nadeau Louise , Valleur Marc 
Published: July 2023

AbstractBackground and aimsIn 1561, physician and philosopher Pascasius Justus Turq published a monograph on the description and treatment of pathological gambling. When the monograph came to the attention of the authors in 2006, there existed no known translation of it in any modern language. In 2014, it was translated and published in French. This paper analyses the monograph’s key content elements and its place in the history of the concept of addiction.MethodsA contextual analysis of the late Italian Renaissance, followed by key excerpts from the text and commentaries on the meaning and significance of the monograph.Findings and conclusionsPascasius Justus Turq’s 1561 monograph on pathological gambling outlines a disease view of gambling, identifies cognitive processes and biological vulnerabilities as aetiological factors, avoids religious or moral judgements and recommends cognitive treatment to change the beliefs and expectancies of gamblers. This study shows that a ‘disease formulation’ of addiction was enunciated as early as the 16th century, and its contemporary resonance suggests that current clinical features of addictive disorders have existed for centuries.
Asymptotics of M‐estimator in multivariate linear regression models for a class of random errors
Authors: Wu Yi , Yu Wei , Wang Xuejun 
Published: July 2023

SummaryIt is known that linear regression models have immense applications in various areas such as engineering technology, economics and social sciences. In this paper, we investigate the asymptotic properties of M‐estimator in multivariate linear regression model based on a class of random errors satisfying a generalised Bernstein‐type inequality. By using the generalised Bernstein‐type inequality, we obtain a general result on almost sure convergence for a class of random variables and then obtain the strong consistency for the M‐estimator in multivariate linear regression models under some mild conditions. The result extends or improves some existing ones in the literature. Moreover, we also consider the case when the dimension $p$ tends to infinity by establishing the rate of almost sure convergence for a class of random variables satisfying generalised Bernstein‐type inequality. Some numerical simulations are also provided to verify the validity of the theoretical results.
Effectiveness of biosimilar adoption within a UK tertiary hospital: 6‐year follow‐up
Authors: Barron Andrew , Chung Jennifer , Ferner Robin E. , Leandro Maria , Maru Saloni , Scourfield Andrew , Urquhart Robert , Sofat Reecha 
Published: July 2023

AbstractHealth systems encourage switching from originators to biosimilars as biosimilars are more cost‐effective. The speed and completeness of biosimilar adoption is a measure of efficiency. We describe the approach to biosimilar adoption at a single hospital Trust and compare its efficiency against the English average. We additionally follow up patients who reverted to a previously used biologic, having switched to a biosimilar, to establish whether they benefitted from re‐establishing prior treatment. The approach we describe resulted in a faster and more complete switch to biosimilars, which saved an additional £380 000 on drug costs in 2021/2022. Of patients who reverted to their original biologic, 87% improved short‐term, and a time on treatment analysis showed the benefit was retained long term. Our approach to biosimilar adoption outperformed the English average and permits patients to revert to their original biosimilar post‐switch if appropriate.
Population dynamics and social organization of sambar (Rusa unicolor unicolor) in Horton Plains National Park, Sri Lanka
Authors: Weerasekera Danushka S. , Perera Sandun J. , McShea William J. , Ranawana Kithsiri B. 
Published: July 2023

AbstractWe estimated the population density and investigated the social organization of sambar (Rusa unicolor unicolor) in Horton Plains National Park (HPNP), Sri Lanka. Distance sampling was conducted along six strip transects every month for a period over 3 years (2018–2020) to estimate the density of the sambar population in grasslands of HPNP (9.4 km2), while the antler stage of males and the behavior of individuals were recorded to describe the population's reproductive stage and hence the social organization. Population density estimates showed relative stability over the 3 years and varied over the seasons but with consistent peaks from year to year with the highest population densities recorded in November–December (212.93 ± 25.38 animals/km2in 2018, 187.91 ± 28.51 in 2019, and 179.76 ± 31.85 in 2020). The highest percentage of males in hard antlers was observed from November through January, while the percentage of antlers cast sambar peaked from March to April each year. Hinds were observed with newborn calves throughout the year, but the highest number of newborn calves were recorded from July to August each year, while the number of calves counted each year varied from 210 to 267 individuals. The mean group size was variable throughout each year with the largest groups recorded from September to December (up to 52), the period accompanied by the most observations of mating and sparring behavior. Although on a tropical island, HPNP is situated on a rolling plateau landscape in the highlands, where sambar showed a degree of reproductive seasonality somewhat similar to temperate cervid species.
In vivo optical imaging of tumor stromal cells with hypoxia‐inducible factor activity
Authors: Miyabara Hitomi , Hirano Ryuichiro , Watanabe Shigeaki , Soriano John Clyde Co , Watanabe Hitomi , Kuchimaru Takahiro , Kitada Nobuo , Kadonosono Tetsuya , Maki Shojiro A. , Kondoh Gen , Kizaka‐Kondoh Shinae 
Published: July 2023

AbstractTumors contain various stromal cells, such as immune cells, endothelial cells, and fibroblasts, which contribute to the development of a tumor‐specific microenvironment characterized by hypoxia and inflammation, and are associated with malignant progression. In this study, we investigated the activity of intratumoral hypoxia‐inducible factor (HIF), which functions as a master regulator of the cellular response to hypoxia and inflammation. We constructed the HIF activity‐monitoring reporter gene hypoxia‐response element‐Venus‐Akaluc (HVA) that expresses the green fluorescent protein Venus and modified firefly luciferase Akaluc in a HIF activity‐dependent manner, and created transgenic mice harboring HVA transgene (HVA‐Tg). In HVA‐Tg, HIF‐active cells can be visualized using AkaBLI, an ultra‐sensitive in vivo bioluminescence imaging technology that produces an intense near‐infrared light upon reaction of Akaluc with the D‐luciferin analog AkaLumine‐HCl. By orthotopic transplantation of E0771, a mouse triple negative breast cancer cell line without a reporter gene, into HVA‐Tg, we succeeded in noninvasively monitoring bioluminescence signals from HIF‐active stromal cells as early as 8 days after transplantation. The HIF‐active stromal cells initially clustered locally and then spread throughout the tumors with growth. Immunohistochemistry and flow cytometry analyses revealed that CD11b+F4/80+ macrophages were the predominant HIF‐active stromal cells in E0771 tumors. These results indicate that HVA‐Tg is a useful tool for spatiotemporal analysis of HIF‐active tumor stromal cells, facilitating investigation of the roles of HIF‐active tumor stromal cells in tumor growth and malignant progression.
Health care concerns in parents of children with different genetic developmental and epileptic encephalopathies: A qualitative study
Authors: Palacios‐Ceña Domingo , Güeita‐Rodríguez Javier , Gil‐Nagel Antonio , Jimenez‐Antona Carmen , García‐Bravo Cristina , Velarde‐García Juan Francisco , Cuenca‐Zaldivar Juan Nicolas , Aledo‐Serrano Ángel 
Published: July 2023

AbstractAimTo describe the experiences and unmet medical care needs of a group of parents of children with developmental and epileptic encephalopathies (DEEs) caused by the SCN1A, KCNQ2, CDKL5, PCDH19, and GNAO1 variants.MethodA qualitative descriptive study was conducted. Participants were recruited using purposeful sampling. The inclusion criteria consisted of parents of children with DEEs caused by the SCN1A, KCNQ2, CDKL5, PCDH19, or GNAO1 variants, aged between 4 and 10 years old. In total, 21 parents were included. Data were acquired via researcher field notes and in‐depth interviews. A thematic analysis was performed.ResultsThree main themes were identified: (1) managing symptoms: epileptic seizures are experienced with great uncertainty and are accompanied by cognitive, behavioural, and motor symptoms; (2) accepting treatment: the ideal medication regimen is a challenge and the decision to withdraw or start a new therapy falls on the parents; and (3) therapeutic relationship and medical care: behaviours related to the health professional can hinder the therapeutic relationship with the parents. Parents are apprehensive about going to the emergency department.InterpretationProfessionals in emergency departments should acquire better knowledge of DEEs, welcome parents, and improve treatment for the children. The results of this study can serve as a starting point for a roadmap of relevant caregiver‐reported outcomes in DEEs, to be implemented with new clinical trials and aetiology‐targeted therapies.What this paper adds

Epileptic seizures are the symptom that is most experienced and feared by parents.
The medication regime has no defined protocol and the decision to withdraw a medication is frequently left to parents.
Female relatives and domestic service in nineteenth‐century England and Wales: Female kin servants revisited
Authors: You Xuesheng 
Published: July 2023

AbstractThis article uses the full sample of the 1851 census enumerators’ books (CEBs) to revisit and reanalyse the well‐known phenomenon of female kin servants in the British census. We find that the recording of female kin servants points to three distinct possibilities – day servants, domestic work at relatives’ homes, and work at relatives’ homes as part of the family business unit. Accordingly, we argue that female kin servants offer a rare opportunity to look into the interaction between gendered work, household economy, and market economy, and they should be considered as much in the labour force as classic servants. We further offer tentative methods to revise the number of female domestic servants. Our revision suggests that domestic service probably employed more women than manufacturing activities of all sorts put together. It highlights the limited impacts of industrialization on most women's work experiences as well as traditional sector's importance for women's employment, even as late as the mid‐nineteenth century.
Effect of the COVID‐19 pandemic on disease activity in multiple sclerosis patients treated with hematopoietic stem cell transplantation
Authors: Mariottini Alice , Lotti Antonio , Innocenti Chiara , Repice Anna Maria , Nozzoli Chiara , Boncompagni Riccardo , Fainardi Enrico , Saccardi Riccardo , Massacesi Luca 
Published: July 2023

AbstractBackground and purposeIt is still debated whether the COVID‐19 pandemic affected disease activity in people with autoimmune diseases, including multiple sclerosis (MS). The aim of this study, therefore, was to explore the impact of COVID‐19 in people with MS (pwMS) not receiving continuative disease‐modifying therapy (DMT) after previous treatment with autologous hematopoietic stem cell transplantation (AHSCT).Materials and methodsWe included pwMS treated with AHSCT who were in disease remission without receiving DMTs during the pandemic and who were followed up at our centre during the study period. Data on SARS‐CoV‐2 infection and vaccination were recorded, with details of adverse events and clinical‐radiological disease activity.ResultsA total of 36 pwMS (31 females; 86%) were included, of whom 23 (64%) had relapsing‐remitting (RR‐MS) and 13 had secondary progressive MS (SP‐MS). Thirty‐three pwMS (92%) received anti‐SARS‐CoV‐2 mRNA vaccines. Thirteen patients (36%) developed mild to moderate COVID‐19 a median (range) of 58 (4–224) months after AHSCT; seven (54%) of these patients were not yet vaccinated. Transient neurological symptoms after vaccination or infection were reported in 9% and 36% of the patients, respectively. The rate of new inflammatory events (relapses or asymptomatic magnetic resonance imaging [MRI] activity) after AHSCT increased from 0.006 (one asymptomatic new lesion/159 patient‐years) before the pandemic to 0.083 (five relapses plus two cases of asymptomatic MRI activity/84 patient‐years) since the pandemic start (p = 0.004).ConclusionsPeople with MS with a history of highly active disease, who are untreated or receiving moderate‐efficacy DMTs might be more vulnerable to disease reactivation, possibly elicited by exogenous triggers. Careful monitoring and further investigation are warranted to ascertain whether special precautions are needed in these cases.