bluuebunny/crossref_metadata_2025_split huggingface dataset:
User Engagement against Online Far-Right Actions in Japan: Driven by High Perceptions of Personal Abilities and Benefits
Authors: Löschke Ayaka 
Published: January 2023

Abstract
This article presents a case study of user engagement against incivility online in Japan, considering three determinants of such engagement identified in a German case study. Japanese users launched the #Internet Rightists Ban Festival in 2018 and are continuing their engagement. As a result, more than 10,500 Twitter accounts have been permanently banned. What drove the participants to initiate and continue their engagement? What type of users attended the festival and led it? This article asks these questions, conducting an inductive qualitative analysis of 3,821 tweets and distinguishing 1,038 participants. It argues that Japanese user engagement has been driven in particular by the perception of personal abilities, such as gaming and comment-writing skills, and the perception of personal benefits, especially from gamification and irony. This article also identifies participants’ left-wing political orientation as an important factor in their continuing sense of responsibility and leadership.
Social Media Advocacy for Gender Equality by Indonesian Men: The Case of Aliansi Laki-laki Baru (New Men’s Alliance)
Authors: Fahadi Prasakti Ramadhana 
Published: January 2023

Abstract
In most parts of the world, men are the dominant gender in power relations. Benefiting from this situation, many are hesitant to support feminism. However, men’s role in the realization of gender equality is crucial. Using interpretive analysis, this research examines how Indonesia’s New Men Alliance/Aliansi Laki-laki Baru (ALB), an activist group that highlights the importance of men’s support for women’s rights, uses social media to advocate gender equality and the strategies they use to effectively communicate their ideas through the frameworks of political solidarity of social change and men’s role in gender equality. The results show that the contents of their Instagram and Facebook page emphasize the urgency of becoming a ‘new man’, while ensuring that the content is relevant both locally and globally. Lastly, ALB strives to exercise its role as an advocate and ally by stepping in without overstepping.
In Search of the Hospices of the Early Byzantine Provincia Arabia (4th–7th centuries ce)
Authors: Piraud-Fournet Pauline 
Published: January 2023

Abstract
From the fourth century ce, Christians were encouraged to redeem their faults by caring for the poor. The most striking manifestation of this phenomenon was the building by the Church of more or less specialised hospices throughout the Early Byzantine Empire (4th to 7th century ce) to accommodate those who depended on charity for their survival. These establishments are mentioned by ancient texts and lapidary inscriptions. About nine such facilities, ptocheion for the needy, xenodocheion for foreigners and travelers, diakonia where food was distributed and other types of charitable hospices can be listed in the ancient province of Arabia (Southern Syria, Northern Jordan). The available data, whether textual or archaeological since some remains are observable on the field, are presented in this paper and compared to those collected elsewhere in the Near East.
The Israel 4 Cloud Seeding Experiment: Primary Results
Authors: Benjamini Yoav , Givati Amir , Khain Pavel , Levi Yoav , Rosenfeld Daniel , Shamir Uri , Siegel Ayal , Zipori Assaf , Ziv Baruch , Steinberg David M. 
Published: January 2023

Abstract
After 38 years of operational cloud seeding for rain enhancement in northern Israel, the Israel 4 experiment was conducted to reassess its effect on rainfall and provide a basis to evaluate its utility. Operational seeding started after two randomized experiments, the second ending in 1976, found a large and statistically significant effect of cloud seeding on rainfall. Observational studies in later years raised doubts as to the magnitude of the effect, possibly because of changing climatological conditions. A carefully designed randomized experiment was conducted from 2013 to 2020. A unique feature of the design was the use of forecast rainfall on target, rather than rainfall in an unaffected area, as a control variate to attenuate variability. The Israel 4 experiment was stopped a year earlier than planned, because the result was disappointing: a 1.8% increase, p value = 0.4, and 95% confidence interval of (−11%, 16%). These results led to a decision by the Israel Water Authority to stop operational seeding.

Significance Statement
The recent cloud seeding experiment in northern Israel did not show a significant rainfall increase—unlike the sequence of seeding experiments conducted in Israel in the previous century.
A Joint Approach Combining Correlation and Mutual Information to Study Land and Ocean Drivers of U.S. Droughts: Methodology
Authors: Shin Chul-Su , Dirmeyer Paul A. , Huang Bohua 
Published: January 2023

Abstract
Normalized mutual information (NMI) is a nonparametric measure of the dependence between two variables without assumptions about the shape of their bivariate data distributions, but the implementation and interpretation of NMI in the coupled climate system is more complicated than for linear correlations. This study presents a joint approach combining correlation and NMI to examine land and ocean surface forcing of U.S. drought at varying lead times. Based on the distribution of correlation versus NMI between a source variable (local or remote forcing) and target variable [e.g., summer precipitation in the southern Great Plains (SGP)], newly proposed one-tail significance levels for NMI combined with two-tailed significance levels of correlation enable us to discern linearity and nonlinearity dominant regimes in a more intuitive way. Our analysis finds that NMI can detect strong linear relationships like correlations, but it is not exclusively tuned to linear relationships as correlations are. Also, NMI can further identify nonlinear relationships, particularly when there are clusters and blank areas (high density and low density) in joint probability distributions between source and target variables (e.g., detected between soil moisture conditions in eastern Montana from mid-February to mid-August and summer precipitation in the SGP). The linear and nonlinear information are found to be sometimes mixed and rather convoluted with time, for instance, in the subtropical Pacific of the Southern Hemisphere, revealing relationships that cannot be fully detected by either NMI or correlation alone. Therefore, this joint approach is a potentially powerful tool to reveal complex and heretofore undetected relationships.
Multi-Institutional Outcomes of Patients Aged 75 years and Older With Pancreatic Ductal Adenocarcinoma Treated With 5-Fraction Ablative Stereotactic Magnetic Resonance Image-Guided Adaptive Radiation Therapy (A-SMART)
Authors: Bryant JM , Palm Russell F , Herrera Roberto , Rubens Muni , Hoffe Sarah E , Kim Dae Won , Kaiser Adeel , Ucar Antonio , Fleming Jason , De Zarraga Fernando , Hodul Pamela , Aparo Santiago , Asbun Horacio , Malafa Mokenge , Jimenez Ramon , Denbo Jason , Frakes Jessica M , Chuong Michael D. 
Published: January 2023

Purpose Treatment options for pancreatic ductal adenocarcinoma (PDAC) are commonly limited for patients with advanced age due to medical comorbidities and/or poor performance status. These patients may not be candidates for more aggressive chemotherapy regimens and/or surgical resection leaving few, if any, other effective treatments. Ablative stereotactic MRI-guided adaptive radiation therapy (A-SMART) is both efficacious and safe for PDAC and can achieve excellent long-term local control, however, the appropriateness of A-SMART for elderly patients with inoperable PDAC is not well understood. Methods A retrospective analysis was performed of inoperable non-metastatic PDAC patients aged 75 years or older treated on the MRIdian Linac at 2 institutions. Clinical outcomes of interest included overall survival (OS), progression-free survival (PFS), distant metastasis-free survival (DMFS), and locoregional (LRC). Toxicity was graded according to Common Terminology Criteria for Adverse Events (CTCAE, v5). Results A total of 49 patients were evaluated with a median age of 81 years (range, 75-91) and a median follow-up of 14 months from diagnosis. PDAC was classified as locally advanced (46.9%), borderline resectable (36.7%), or medically inoperable (16.3%). Neoadjuvant chemotherapy was delivered to 84% of patients and all received A-SMART to a median 50 Gy (range, 40-50 Gy) in 5 fractions. 1 Year LRC, PFS, and OS were 88.9%, 53.8%, and 78.9%, respectively. Nine patients (18%) had resection after A-SMART and benefited from PFS improvement (26 vs 6 months, P = .01). ECOG PS <2 was the only predictor of improved OS on multivariate analysis. Acute and late grade 3 + toxicity rates were 8.2% and 4.1%, respectively. Conclusions A-SMART is associated with encouraging LRC and OS in elderly patients with initially inoperable PDAC. This novel non-invasive treatment strategy appears to be well-tolerated in patients with advanced age and should be considered in this population that has limited treatment options.
Cycle-dependent eosinophilia due to adjuvant nivolumab for malignant melanoma
Authors: Habibi Shaghayegh , Soliman Abram , Dasanu Constantin A. 
Published: January 2023

Introduction Immune checkpoint inhibitors (ICIs) have been widely used in the contemporary anticancer armamentarium. However, new side effects due to these agents have continued to emerge. Case report We describe herein a 71-year-old patient who received nivolumab as adjuvant therapy for malignant melanoma of the skin. He developed eosinophilia starting at 4 weeks of therapy. Eosinophilia increased progressively during the first six nivolumab cycles, then stabilized. Cycle-dependent increments were observed. Subsequently, the patient experienced well-known side effects of ICIs such as grade 1 diarrhea, arthralgias, and erythematous papular rash. Management and outcome Nivolumab was continued, and absolute eosinophil counts were monitored. Prednisone 10 mg PO daily was required for moderate gastroenteritis, dermatitis, and arthritis, which all subsequently improved. Eosinophil levels gradually downtrended after starting prednisone. Causality assessment between nivolumab and eosinophilia via adverse drug reaction (ADR) probability scale revealed a score of 9. Discussion Physicians and pharmacists need to be aware of this important side effect of ICI therapy. Eosinophilia in the context of ICI use has been previously reported in clinical trials. Our case is unique as eosinophilia was cumulative, showed increments every 8 weeks, and exhibited a trend toward cycle dependency. Extensive and expensive workup does not appear warranted, and simple monitoring of complete blood count is appropriate in most patients. Further studies are necessary to assess the true incidence, pattern, and severity of eosinophilia related to ICIs as well as its association with clinical outcomes.
Eating disorder mental health literacy: A national survey of clinical social workers in the United States
Authors: MacCaughelty Chelsea R. 
Published: January 2023

Summary Social workers’ eating disorder mental health literacy (ED-MHL) is essential to the detection, assessment, and treatment of eating disorders (EDs) and disordered eating (DE) in clinical practice. This study explored social workers’ ED-MHL, particularly the assessment practices of EDs on intake forms, and within the first two therapy sessions. Participants in this national survey were N = 316 outpatient masters-level social workers in the United States. Participants completed an online survey measuring ED assessment practices in clinical practice. Findings Results showed that 42.4% ( n = 133) of respondents did not routinely assess for EDs/DE on clinical intake forms, and 53.2% ( n = 165) did not assess within the first two therapy sessions. However, those with recent training related to EDs were more likely to assess. Participants reported low to moderate perceived comfort levels with the assessment of EDs, and training and education were identified as needed resources. Social workers reported deficits in their own assessment practices of EDs. Barriers included: lack of training about EDs/DE; uncertainty about process questions to ask; and perceptions that EDs/DE are rarely the client's primary presenting problem. Applications Difficulties with detection and screening practices appeared contingent on gaps in existing education and training related to EDs/DE. These findings suggest that future research may serve to increase social workers’ ED-MHL, as underscored by the noteworthy finding that 86.1% ( n = 229) of the sample reported that they would make proactive changes in their clinical practice, as a direct result of participating in this study.
A comparison of transient elastography with acoustic radiation force impulse elastography for the assessment of liver health in patients with chronic hepatitis C: Baseline results from the TRACER study
Authors: Herlihy Therese , Moran Mary , Heeney Aoife , Okhai Hajra , De Franceso Davide , Cronin Carmel , Feeney Eoin , Houlihan Diarmuid , Stewart Stephen , Cotter Aoife G 
Published: January 2023

Background: Liver stiffness measurements can be used to assess liver fibrosis and can be acquired by transient elastography using FibroScan® and with Acoustic Radiation Force Impulse imaging. The study aimed to establish liver stiffness measurement scores using FibroScan® and Acoustic Radiation Force Impulse in a chronic hepatitis C cohort and to explore the correlation and agreement between the scores and the factors influencing agreement. Methods: Patients had liver stiffness measurements acquired with FibroScan® (right lobe of liver) and Acoustic Radiation Force Impulse (right and left lobe of liver). We used Spearman’s correlation to explore the relationship between FibroScan® and Acoustic Radiation Force Impulse scores. A Bland–Altman plot was used to evaluate bias between the mean percentage differences of FibroScan® and Acoustic Radiation Force Impulse scores. Univariable and multivariable analyses were used to assess how factors such as body mass index, age and gender influenced the agreement between liver stiffness measurements. Results: Bland-Altman showed the average (95% CI) percentage difference between FibroScan® and Acoustic Radiation Force Impulse scores was 27.5% (17.8, 37.2), p < 0.001. There was a negative correlation between the average and percentage difference of the FibroScan® and Acoustic Radiation Force Impulse scores ( r (95% CI) = −0.41 (−0.57, −0.21), p < 0.001), thus showing that percentage difference gets smaller for greater FibroScan® and Acoustic Radiation Force Impulse scores. Body mass index was the biggest influencing factor on differences between FibroScan® and Acoustic Radiation Force Impulse ( r = 0.12 (0.01, 0.23), p = 0.05). Acoustic Radiation Force Impulse scores at segment 5/8 and the left lobe showed good correlation ( r (95% CI) = 0.83 (0.75, 0.89), p < 0.001). Conclusion: FibroScan® and Acoustic Radiation Force Impulse had similar predictive values for the assessment of liver stiffness in patients with chronic hepatitis C infection; however, the level of agreement varied across lower and higher scores.
Identification of biomarkers and therapeutic targets related to Sepsis-associated encephalopathy in rats by quantitative proteomics
Authors: Yang Miaoxian , He Yu , Xin Yuewen , Jiang Junliang , Tian Mi , Tan Jiaying , Deng Shuixiang , Gong Ye 
Published: January 2023

AbstractBackgroundSepsis-associated encephalopathy (SAE) is a common and severe complication of sepsis. While several studies have reported the proteomic alteration in plasma, urine, heart, etc. of sepsis, few research focused on the brain tissue. This study aims at discovering the differentially abundant proteins in the brains of septic rats to identify biomarkers of SAE.MethodsThe Prague-Dawley rats were randomly divided into sepsis (n = 6) or sham (n = 6) groups, and then the whole brain tissue was dissected at 24 h after surgery for further protein identification by Quantitative iTRAQ LC-MS/MS Proteomics. Ingenuity pathway analysis, Gene ontology knowledgebase, and STRING database are used to explore the biological significance of proteins with altered concentration.ResultsAmong the total of 3163 proteins identified in the brain tissue, 57 were increased while 38 were decreased in the sepsis group compared to the sham group. Bioinformatic analyses suggest that the differentially abundant proteins are highly related to cellular microtubule metabolism, energy production, nucleic acid metabolism, neurological disease, etc. Additionally, acute phase response signaling was possibly activated and PI3K/AKT signaling was suppressed during sepsis. An interaction network established by IPA revealed that Akt1, Gc-globulin, and ApoA1 were the core proteins. The increase of Gc-globulin and the decrease of Akt1 and ApoA1 were confirmed by Western blot.ConclusionBased on the multifunction of these proteins in several brain diseases, we first propose that Gc-globulin, ApoA1, PI3K/AKT pathway, and acute phase response proteins (hemopexin and cluster of alpha-2-macroglobulin) could be potential candidates for the diagnosis and treatment of SAE. These results may provide new insights into the pathologic mechanism of SAE, yet further research is required to explore the functional implications and clinical applications of the differentially abundant proteins in the brains of sepsis group.
A nomogram for predicting the mortality of patients with type 2 diabetes mellitus complicated with acute kidney injury in the intensive care unit
Authors: Liu Shizhen , Qiu Chuangye , Li Xingai , Yu Zongchao , Liu Fanna , Hu Guoqiang 
Published: January 2023

Abstract
Background
There is no predictive tool for type 2 diabetes mellitus (T2DM) patients with acute kidney injury (AKI). Our study aimed to establish an effective nomogram model for predicting mortality in T2DM patients with AKI.

Method
Data on T2DM patients with AKI were obtained from the Medical Information Mart for Intensive Care III. 70% and 30% of the patients were randomly selected as the training and validation cohorts, respectively. Univariate and multivariate logistic regression analyses were used to identify factors associated with death in T2DM patients with AKI. Factors significantly associated with survival outcomes were used to construct a nomogram predicting 90-day mortality. The nomogram effect was evaluated by receiver operating characteristic curve analysis, Hosmer‒Lemeshow test, calibration curve, and decision curve analysis (DCA).

Results
There were 4375 patients in the training cohort and 1879 in the validation cohort. Multivariate logistic regression analysis showed that age, BMI, chronic heart failure, coronary artery disease, malignancy, stages of AKI, white blood cell count, blood urea nitrogen, arterial partial pressure of oxygen and partial thromboplastin time were independent predictors of patient survival. The results showed that the nomogram had a higher area under the curve value than the sequential organ failure assessment score and simplified acute physiology score II. The Hosmer‒Lemeshow test and calibration curve suggested that the nomogram had a good calibration effect. The DCA curve showed that the nomogram model had good clinical application value.

Conclusion
The nomogram model accurately predicted 90-day mortality in T2DM patients with AKI. It may provide assistance for clinical decision-making and treatment, thereby reducing the medical burden.
Clinical characteristics of 14 pediatric mycoplasma pneumoniae pneumonia associated thrombosis: a retrospective study
Authors: Fu Y. , Zhang T. Q. , Dong C. J. , Xu Y. S. , Dong H. Q. , Ning J. 
Published: January 2023

Abstract
Objective
This study aimed to investigate the clinical characteristics and long-term prognosis of mycoplasma pneumoniae pneumonia (MPP)-associated thrombosis and to gain a better understanding of the diagnosis and treatment of the disease.

Methods
The medical records of 14 children with MPP-associated thrombosis between January 2016 and April 2020 were retrospectively reviewed at the Tianjin Children’s Hospital.

Results
The ages of the patients ranged from 3 to 12 years old. Among the 14 cases, there were five cases of pulmonary embolism, two cases of cerebral infarction, one case of splenic infarction, one case of cardiac embolism, two cases of cardiac embolism with comorbid pulmonary embolism, one case of internal carotid artery and pulmonary embolism, one case of combined internal carotid artery and the cerebral infarction, and one case combined cardiac embolism and lower limb artery embolism. All cases had elevated D-dimer levels. After thrombolysis and anticoagulation therapy, three cases with cerebral embolism still suffered from neurological sequelae. In contrast, the remaining cases did not develop complications.

Conclusion
MPP-associated thrombosis can occur in any vessel of the body. Thrombosis-associated symptoms may be complex and non-specific. Elevated D-dimer levels in a child with refractory mycoplasma pneumoniae pneumonia should raise suspicion of thrombosis. The long-term prognosis of thrombosis was favorable after the timely administration of anticoagulant therapy.
Real-world data in primary care: validation of diagnosis of atrial fibrillation in primary care electronic medical records and estimated prevalence among consulting patients’
Authors: de Burgos-Lunar C. , del Cura-González I. , Cárdenas-Valladolid J. , Gómez-Campelo P. , Abánades-Herranz J. C. , López-de Andrés A. , Sotos-Prieto M. , Iriarte-Campo V. , Salinero-Fort M. A. 
Published: January 2023

Abstract
Background
Primary care electronic medical records contain clinical-administrative information on a high percentage of the population. Before this information can be used for epidemiological purposes, its quality must be verified.
This study aims to validate diagnoses of atrial fibrillation (AF) recorded in primary care electronic medical records and to estimate the prevalence of AF in the population attending primary care consultations.

Methods
We performed a cross-sectional validation study of all diagnoses of AF recorded in primary care electronic medical records in Madrid (Spain).
We also performed simple random sampling of diagnoses of AF (ICPC-2 code K78) registered by 55 physicians and random age- and sex-matched sampling of the records that included a diagnosis of AF. Electrocardiograms, echocardiograms, and hospital discharge or cardiology clinic reports were matched.
Sensitivity, specificity, positive and negative predictive values (PPV and NPV), and overall agreement were calculated using the kappa statistic (κ). The prevalence of AF in the community of Madrid was estimated considering the sensitivity and specificity obtained in the validation. All calculations were performed overall and by sex and age groups.

Results
The degree of agreement was very high (κ = 0.952), with a sensitivity of 97.84%, specificity of 97.39%, PPV of 97.37%, and NPV of 97.85%.
The prevalence of AF in the population aged over 18 years was 2.41% (95%CI 2.39–2.42% [2.25% in women and 2.58% in men]). This increased progressively with age, reaching 16.95% in those over 80 years of age (15.5% in women and 19.44% in men).

Conclusions
The validation results obtained enable diagnosis of AF recorded in primary care to be used as a tool for epidemiological studies.
A high prevalence of AF was found, especially in older patients.