bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrafast Humidity Sensing Layers Made by Two‐Photon Polymerization and Initiated Chemical Vapor Deposition
Authors: Cesnik Stefan , Hernández Rodríguez Gabriel , Bergmann Alexander , Coclite Anna Maria 
Published: April 2023

AbstractHumidity sensors are used in many applications. The design of fast sensors that can operate in explosive environments is a difficult task. Therefore, current research efforts aim at combining reliability, sensitivity and high sensing speed. The use of structured ultrathin hydrogels perfectly meets these requirements. Nanostructures are directly fabricated with a two‐photon‐polymerisation (2PP) 3D printer to use them as templates for hydrogels. After the 3D printing multiple templates are coated with ultrathin films of poly(2‐hydroxyethyl‐methacrylate) (pHEMA) using initiated chemical vapor deposition (iCVD). p(HEMA) is a humidity responsive hydrogel which changes its thickness by orders of magnitude depending on the ambient conditions. The 3D printed structures are optimized to give both a fast response time, and an optical read‐out method for visible wavelengths. Upon hydrogel swelling, the height of the nanostructure pillars increases, keeping their periodicity constant. This induces a change in intensity of the first ‐order refraction peak, which can be easily measured also at low humidity levels. The humidity response of the nanostructures is measured and an influence for different hydrogel thicknesses and humidity flow rates is observed. The ultrathin film with the lowest thickness of 50 nm shows the fastest response to relative humidity, which is much faster than commercial sensors with 8 s response time.
Understanding farmers’ engagement and barriers to machine learning‐based intelligent agricultural decision support systems
Authors: Adereti Damilola Tobiloba , Gardezi Maaz , Wang Tong , McMaine John 
Published: April 2023

AbstractThe use of intelligent decision support systems (DSS) in precision farming provides an opportunity to improve agricultural recommendations and reduce the impacts of agriculture on the environment. Despite the benefits offered by DDS, many farmers remain skeptical of using these hardware and software tools, and their adoption rates have remained low. A survey of 312 South Dakota farmers examined the barriers and opportunities for their engagement with DSS. Exploratory factor analysis was used to analyze 13 Likert scale survey items that probed farmers’ concerns about DSS. Factor loadings indicated that farmers’ concerns are related to high cost, insufficient knowledge, lack of confidence, and cyber security and privacy. A latent profile analysis (LPA) method was used to classify respondents into profiles or groups based on their dimensions of concerns (cost, knowledge, confidence, and security). Results of the LPA revealed that the sample of farmers could be grouped into four distinct profiles that ranged from low to high confidence in the use of DSS for agronomic decision‐making. Giving attention to farmer comfort/concern profiles allows for a more inclusive and better targeted engagement with farmers and potentially increase the adoption of PA. This knowledge can be vital for technology developers, policymakers, and extension services who are keen to promote PA usage among large‐, medium‐, and small‐scale farmers in the United States.
The clinical phenotype of Koolen‐de Vries syndrome in Turkish patients and literature review
Authors: Karamik Gokcen , Tuysuz Beyhan , Isik Esra , Yilmaz Aysegul , Alanay Yasemin , Sunamak Evrim Cifci , Durmusalioglu Enise Avci , Ozkinay Ferda , Cetin Gokhan Ozan , Ozturk Nuray , Mihci Ercan , Nur Banu 
Published: April 2023

AbstractKoolen‐de Vries syndrome (KdVS) is a rare multisystemic disorder caused by a microdeletion on chromosome 17q21.31 including KANSL1 gene or intragenic pathogenic variants in KANSL1 gene. Here, we describe the clinical and genetic spectrum of eight Turkish children with KdVS due to a de novo 17q21.31 deletion, and report on several rare/new conditions. Eight patients from unrelated families aged between 17 months and 19 years enrolled in this study. All patients evaluated by a clinical geneticist, and the clinical diagnosis were confirmed by molecular karyotyping. KdVS patients had some common distinctive facial features. All patients had neuromotor retardation, and speech and language delay. Epilepsy, structural brain anomalies, ocular, ectodermal, and musculoskeletal findings, and friendly personality were remarkable in more than half of the patients. Hypertension, hypothyroidism, celiac disease, and postaxial polydactyly were among the rare/new conditions. Our study contributes to the clinical spectrum of patients with KdVS, while also provide a review by comparing them with previous cohort studies.
First experience of combined enzyme replacement therapy and hematopoietic stem cell transplantation in alpha‐mannosidosis
Authors: Santoro Lucia , Monachesi Chiara , Zampini Lucia , Padella Lucia , Galeazzi Tiziana , Santori Elena , Cordiali Rosanna , Dardis Andrea , Catassi Carlo , Boccieri Emilia , Galaverna Federica , Locatelli Franco 
Published: April 2023

AbstractWe describe the first case of bridge therapy in alpha‐mannosidosis (AM) in an infant diagnosed at only 5 months of life who underwent enzyme replacement therapy (ERT) in the pre‐ and peri‐transplant phases. Eight ERT infusions were administered before hematopoietic stem cell transplantation (HSCT) and continued for additional 90 days until complete engraftment. The clinical and laboratory data after 3 years post‐HSCT show that the early combined intervention may reduce the disease progression and the urine and plasma content of mannosyl‐oligosaccharides (OS) monitored by liquid chromatography tandem mass spectrometry (LC–MS/MS). This report highlights that early diagnosis and prompt initiation of such treatments in AM are the best chance to minimize the progression of symptoms.
A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease
Authors: Bai Haimeng , Naj Adam C. , Benchek Penelope , Dumitrescu Logan , Hohman Timothy , Hamilton‐Nelson Kara , Kallianpur Asha R. , Griswold Anthony J. , Vardarajan Badri , Martin Eden R. , Beecham Gary W. , Below Jennifer E. , Schellenberg Gerard , Mayeux Richard , Farrer Lindsay , Pericak‐Vance Margaret A. , Haines Jonathan L. , Bush William S. ,   Alzheimer's Disease Genetics Consortium
Published: April 2023

AbstractBackgroundHaptoglobin (HP) is an antioxidant of apolipoprotein E (APOE), and previous reports have shown HP binds with APOE and amyloid beta (Aβ) to aid its clearance. A common structural variant of the HP gene distinguishes it into two alleles: HP1 and HP2.MethodsHP genotypes were imputed in 29 cohorts from the Alzheimer's Disease Genetics Consortium (N = 20,512). Associations between the HP polymorphism and Alzheimer's disease (AD) risk and age of onset through APOE interactions were investigated using regression models.ResultsThe HP polymorphism significantly impacts AD risk in European‐descent individuals (and in meta‐analysis with African‐descent individuals) by modifying both the protective effect of APOE ε2 and the detrimental effect of APOE ε4. The effect is particularly significant among APOE ε4 carriers.DiscussionThe effect modification of APOE by HP suggests adjustment and/or stratification by HP genotype is warranted when APOE risk is considered. Our findings also provided directions for further investigations on potential mechanisms behind this association.
Variation in the utilization of angioembolization for splenic injury in hospitals: a nationwide cross‐sectional study in Japan
Authors: Aoki Makoto , Abe Toshikazu , Hagiwara Shuichi , Saitoh Daizoh 
Published: April 2023

AimSubstantial variations in the utilization of angioembolization have been reported internationally. However, the existence of variations in the utilization of angioembolization in Japan is currently unknown.MethodsThis was a cross‐sectional study using data from a nationwide trauma registry in Japan. Of the 4,896 registered adult patients with splenic injury, we investigated 3,319 patients in the top 25% of the hospitals that registered the highest number of splenic injury patients in the Japan Trauma Data Bank. The primary outcome of this study was initial angioembolization. We calculated the expected initial angioembolization rates using multiple regression analysis adjusted for patient factors. In addition, we evaluated the range of observed‐to‐expected initial splenic angioembolization ratio for each hospital. Moreover, we assessed whether this ratio was increased with time.ResultsThe frequency of initial splenic angioembolization ranged from 0% to 52%. The median expected initial angioembolization rate, calculated through multiple logistic regression analysis, was 19.7%. The observed‐to‐expected initial splenic angioembolization ratio for each hospital ranged from 0 to 2.36. The observed initial angioembolization rate tended to increase with time (P < 0.001).ConclusionsDespite adjustment for patient factors, substantial variations were observed in the utilization of splenic angioembolization among hospitals in Japan.
Effect of canola meal fermentation and protein extraction method on the functional properties of resulting protein products
Authors: Li Chenghao , Shi Dai , Stone Andrea K. , Wanasundara Janitha P. D. , Tanaka Takuji , Nickerson Michael T. 
Published: April 2023

AbstractThe present study investigated the effect of solid‐state fermentation (SSF) of cold‐pressed (CP) and hexane‐extracted (HE) canola meals with Aspergillus niger NRRL 334 and Aspergillus oryzae NRRL 5590 on the functionalities of protein products extracted from them. After SSF, proteins were recovered using alkaline extraction‐isoelectric precipitation (AE‐IP) or salt extraction‐dialysis (SE). SSF of the two meal types reduced the protein content of the extracts produced by AE‐IP. There were varied effects to solubility, foaming, and emulsifying properties as a result of SSF under the combined influence of functionality pH, strain, meal type, and protein extraction method. The protein isolate produced from CP meal using SE had increased solubility at pH 7 (from 51.8% to 90.7%) when the meal was fermented with A. oryzae. Both strains resulted in an over twofold increase in the emulsifying activity index (at pH 7) of AE‐IP products from CP meal. For both protein extraction methods, the protein products from A. niger fermented HE meal had better foaming capacity (FC) at pH 7 than the controls (non‐fermented), but reduced FC at pH 3. Overall, regardless of meal fermentation, the SE products were richer in protein and had higher oil holding capacity (OHC), whereas the water holding capacity (WHC) was higher for AE‐IP isolates. SSF of the meals generally improved the O/WHC of the extracted proteins. The findings suggest that canola protein functionality could be effectively modulated by SSF with different microbial strains under various processing conditions to enhance their applicability in the food industry.
Clinical misdiagnosis of influenza infection with a confusing clinical course: A case report
Authors: Babazadeh Arefeh , Mohseni Afshar Zeinab , Barary Mohammad , Hosseinzadeh Rezvan , Ebrahimpour Soheil 
Published: April 2023

AbstractA 32‐year‐old woman with a history of hypothyroidism and major depressive disorder was admitted with severe weakness and somnolence. She had tachycardia and hypotension, indicative of severe dehydration, and was treated with a vasopressor and sodium bicarbonate, but her clinical manifestations deteriorated. A high‐resolution computed tomography (HRCT) scan showed a patchy ground glass appearance with interlobular septal thickening, suggesting pneumonia. Reverse transcription‐polymerase chain reaction (RT‐PCR) was requested for the influenza A virus (IAV), which was positive. The patient was treated with oseltamivir and discharged with improved clinical symptoms.
Research progress on the application of hyperspectral imaging techniques in tea science
Authors: Liang Dongxia , Zhou Qiaoyi , Ling Caijin , Gao Liyang , Mu Xiaoting , Liao Zhencheng 
Published: April 2023

AbstractHyperspectral imaging technology combines two‐dimensional imaging and spectral technology, which can simultaneously obtain spatial and spectral information of the object to be measured and is an advanced technical method. With the development of science and technology, the detection of tea has also been continuously improved, and it has developed in the direction of being nondestructive, fast, real‐time, and accurate. In this paper, the principle of hyperspectral imaging technology is introduced, and according to research on hyperspectral imaging technology in the nondestructive rapid detection of tea in the past 5 years, the application of hyperspectral imaging technology in the detection of tea biochemical components, accurate classification, determination of mildew degree, and stress monitoring and the application progress in planting production management are analyzed. Additionally, the main challenges existing in the current research are analyzed, and future application prospects are proposed to provide a reference for the application and promotion of hyperspectral imaging technology in the actual production of tea.
DNA‐induced circularly polarized luminescence of helicene racemates
Authors: Gan Fuwei , Yang Peng , Liang Juncong , Shen Chengshuo , Crassous Jeanne , Qiu Huibin 
Published: April 2023

AbstractEnantiopure helicenes have been extensively investigated due to their outstanding chiroptical properties, while helicene racemates are considered as chiroptically silent. Here, we describe a facile method to produce circularly polarized luminescence (CPL) from helicene racemates via supramolecular association with DNA in aqueous solution. Racemic cationic helicene derivatives are immobilized in the grooves of commercially available double‐stranded right‐handed DNA, and the discrimination of left‐ and right‐handed helicenes by chiral DNA is monitored by single molecule force spectroscopy. This subsequently leads to the generation of prominent CPL with dissymmetric factor |glum| of close to 0.01, which is approximate to enantiopure helicenes. The strategy developed in this work avoids the tedious and expensive chiral resolution process and provides a distinctive insight into the fabrication of CPL‐emitting systems.
13C and 15N Benchtop NMR Detection of Metabolites via Relayed Hyperpolarization**
Authors: Alcicek Seyma , Van Dyke Erik , Xu Jingyan , Pustelny Szymon , Barskiy Danila A. 
Published: April 2023

AbstractParahydrogen‐based nuclear spin hyperpolarization allows various magnetic‐resonance applications, and it is particularly attractive because of its technical simplicity, low cost, and ability to quickly (in seconds) produce large volumes of hyperpolarized material. Although many parahydrogen‐based techniques have emerged, some of them remain unexplored due to the lack of careful optimization studies. In this work, we investigate and optimize a novel parahydrogen‐induced polarization (PHIP) technique that relies on proton exchange referred to below as PHIP‐relay. An INEPT (insensitive nuclei enhanced by polarization transfer) sequence is employed to transfer polarization from hyperpolarized protons to heteronuclei (
N and
C) and nuclear signals are detected using benchtop NMR spectrometers (1 T and 1.4 T, respectively). We demonstrate the applicability of the PHIP‐relay technique for hyperpolarization of a wide range of biochemicals by examining such key metabolites as urea, ammonium, glucose, amino acid glycine, and a drug precursor benzamide. By optimizing chemical and NMR parameters of the PHIP‐relay, we achieve a 17,100‐fold enhancement of
N signal of [
C,
N
]‐urea compared to the thermal signal measured at 1 T. We also show that repeated measurements with shorter exposure to parahydrogen provide a higher effective signal‐to‐noise ratio compared to longer parahydrogen bubbling.
WSO‐T2FSM: War strategy optimization‐based type‐2 fuzzy‐based starling murmuration for addressing the routing problem in mobile ad hoc network
Authors: Ahila Devi E. , Chandrasekar A. , Radhika S. 
Published: April 2023

SummaryNowadays, research based on mobile ad hoc network's (MANET) performance improvement has drawn a particular concentration from scientists worldwide. The shortest path selection among destination and source nodes determines the network's throughput in MANET. In addition, power management and energy consumption are also the major difficulties that MANET suffers. The conventional routing protocols are intended for static bonding, but that protocol does not satisfy the stability in ad hoc networks by means of regularly changing connectivity. This shows the routing problem in MANETs. Therefore, to overcome the routing issues and maintain energy efficiently, the Type‐2 fuzzy‐based Starling Murmuration Optimizer (SMO)‐War Strategy Optimization (WSO) (T2FSMO‐WSO) routing protocol is proposed in this paper. MANET takes into account four input parameters: route length, active link ratio to global traffic, network lifetime, and control packet ratio. The SMO algorithm is employed to choose the relay node with low energy consumption. The trapezoidal membership functions are used to describe the fuzzy sets for these parameters. The content‐based routing among source and destination nodes is determined using the WSO algorithm. The simulation outcomes reveal that the proposed method discovers highly stable paths with minimum distance and minimized the consumption of energy.
An autonomic resource management system for energy efficient and quality of service aware resource scheduling in cloud environment
Authors: Kumar Ashok , Lal Madan , Kaur Sumandeep 
Published: April 2023

SummaryEfficient utilization of resources is a challenging task in cloud computing due to heterogeneity of resources and fluctuating resource demands of multifarious applications. This article presents an autonomic resource allocation approach for energy efficient utilization of resources while satisfying QoS needs of the end‐users. The proposed approach is based on antlion optimization and makes use of resource utilization history for autonomic allocation and efficient use of resources. It can operate in one of the three different modes namely, energy‐saving, performance, and balanced mode depending on the projected workload of an application. The performance analysis of the proposed approach is carried out in CloudSim simulator under different workload conditions.
The impacts of tenure diversity on boardroom and corporate carbon emission performance: Exploring from the moderating role of corporate innovation
Authors: Cahyono Suham , Harymawan Iman , Kamarudin Khairul Anuar 
Published: April 2023

AbstractThis paper examines the relationship between tenure diversity, corporate innovation, and carbon emission performance in developing countries, with a particular focus on the interaction model of corporate innovation in the nexus. The study is conducted in a unique setting of Indonesian firms with a high level of tenure diversity and carbon performance, excluding the financial industry from 2015 to 2021 and covering 1466 firm‐year observations. The study confirms that tenure diversity in the boardroom is a significant driver in reducing carbon emissions, as it has the potential to lower emissions during production cycles. However, the results suggest that there may be a poor decline in emissions when firms are too diverse. The authors' findings are robust and consistent over several robustness checks and endogeneity tests. This study is the first to focus on a quantitative measurement of carbon emission performance based on the Global Reporting Initiative in developing countries.
Sponge diversification in marine lakes: Implications for phylogeography and population genomic studies on sponges
Authors: Maas Diede L. , Prost Stefan , de Leeuw Christiaan A. , Bi Ke , Smith Lydia L. , Purwanto Purwanto , Aji Ludi P. , Tapilatu Ricardo F. , Gillespie Rosemary G. , Becking Leontine E. 
Published: April 2023

AbstractThe relative influence of geography, currents, and environment on gene flow within sessile marine species remains an open question. Detecting subtle genetic differentiation at small scales is challenging in benthic populations due to large effective population sizes, general lack of resolution in genetic markers, and because barriers to dispersal often remain elusive. Marine lakes can circumvent confounding factors by providing discrete and replicated ecosystems. Using high‐resolution double digest restriction‐site‐associated DNA sequencing (4826 Single Nucleotide Polymorphisms, SNPs), we genotyped populations of the sponge Suberites diversicolor (n = 125) to test the relative importance of spatial scales (1–1400 km), local environmental conditions, and permeability of seascape barriers in shaping population genomic structure. With the SNP dataset, we show strong intralineage population structure, even at scales <10 km (average FST = 0.63), which was not detected previously using single markers. Most variation was explained by differentiation between populations (AMOVA: 48.8%) with signatures of population size declines and bottlenecks per lake. Although the populations were strongly structured, we did not detect significant effects of geographic distance, local environments, or degree of connection to the sea on population structure, suggesting mechanisms such as founder events with subsequent priority effects may be at play. We show that the inclusion of morphologically cryptic lineages that can be detected with the COI marker can reduce the obtained SNP set by around 90%. Future work on sponge genomics should confirm that only one lineage is included. Our results call for a reassessment of poorly dispersing benthic organisms that were previously assumed to be highly connected based on low‐resolution markers.