bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barrel rifling node offset detection and subsequent optimization based on thin film IMD characteristics Johnson-cook model
Authors: Chang Hanjui , Zhang Guangyi , Sun Yue , Lu Shuzhou , Wang Rui 
Published: June 2023

Abstract

This paper proposes a nodal detection method for the detection and optimization of barrel helix offset, the barrel used in this experiment is a 3-helix barrel, which will use the special properties of the film to cover the surface of the barrel helix with a virtual IMD film, and use the unique nature of the film die offset in IMD to detect the position of the barrel helix, the area with a large die index is the area with a large helix offset of the barrel, and the IMD die index is introduced to quantify the data. The IMD die index is used to determine the helix offset of the damaged barrel. The novelty of this work is that each node can use the die index to efficiently detect the position of the barrel helix deviation, and then carry out subsequent optimization and repair work through the optimization of injection molding parameters and the design optimization of the barrel, and verify the experiment by comparing the results. Through the steady-state research mode under simulation, different permutations and combinations of the two process parameters are simulated to study their influence in the processing process. Quantitative reference indicators include but are not limited to dependent variables such as fluid flow velocity, shear rate, temperature distribution and phase transition, and the shear heating process of the injection screw is taken into account in the mold flow analysis to ensure that the die index value is more accurate. It can be seen from the analysis results that the temperature of the barrel changes after changing the groove depth and groove width, and the effect ratio of groove depth is lower than that of groove width in the same degree of size change.
First report of Culex (Culex) camposi Dyar, 1925 and Culex (Carrollia) bonnei Dyar, 1921 via male genitalia and CoxI barcoding sequence analyses in Huanuco, Peru
Authors: Sabino Eddyson Montalvo , Marquez-Ocaña Omayra P. , Otiniano-Moreno Griselda A. , Condezo Gizeth K. Daza , Chuquiyauri-Talenas Miguel A. , Melo Tiago , Seixas Gonçalo , Parreira Ricardo , de Almeida António Paulo Gouveia 
Published: June 2023

Abstract
Mosquitoes (Diptera: Culicidae) pose a significant threat to public health worldwide, especially in tropical and subtropical regions, where they act as primary vectors in transmission of infectious agents. In Peru, where 182 culicid species have been identified, several species of the genus Culex are known to transmit arboviruses. However, knowledge of the diversity and distribution of mosquitoes remains limited, with many studies focusing on specific regions only. This study reports the presence of two mosquito species in Peru: ex-larvae Culex (Culex) camposi Dyar, 1925 and Cx. (Carrollia) bonnei Dyar, 1921, identified through larval collections and molecular analyses. In total, 10 mosquitoes (8 males and 2 females) were analyzed, the dissection of the genitalia of the 8 male specimens allowed the identification of the species Cx. camposi and Cx. bonnei. A total of 10 partial sequences of the CoxI gene corresponding to these two species were obtained. Phylogenetic analysis revealed that the sequences of Cx. camposi formed the same monophyletic clade with sequences from species of the Coronator complex, in addition to presenting a divergence of less than 2%, while Cx. bonnei, formed in a monophyletic clade, with > 2% divergence with sequences from other species corresponding to the subgenus Carrollia. This study underscores the importance of continued efforts to study the diversity and distribution of mosquitoes in Peru, including their potential role as vectors of human pathogens, to underpin effective disease control and prevention strategies.
Filamentous Fungus-Produced Human Monoclonal Antibody Provides SARS-CoV-2 Protection in Hamster and Non-Human Primate Models
Authors: Kaiser Franziska , Hernandez Mariana Gonzalez , Krüger Nadine , Englund Ellinor , Du Wenjuan , Mykytyn Anna , Raadsen Mathijs , Lamers Mart , Ianiski Francine Rodrigues , Shamorkina Tatiana , Snijder Joost , Armando Federico , Beythien Georg , Ciurkiewicz Malgorzata , Schreiner Tom , Gruber-Dujardin Eva Eva , Bleyer Martina , Batura Olga , Erffmeier Lena , Hinkel Rabea , Rocha Cheila , Mirolo Monica , Drabek Dubravka , Bosch Berend-Jan , Emalfarb Mark , Valbuena Noelia , Tchele Ronen , Baumgärtner Wolfgang , Saloheimo Markku , Pöhlmann Stefan , Grosveld Frank , Haagmans Bart , Osterhaus Albert 
Published: June 2023

Abstract
Monoclonal antibodies are an increasingly important tool for prophylaxis and treatment of acute virus infections like those with SARS-CoV-2. However, their use is largely limited by the length of development, yield and high production costs, as well as the need for continuous adaptation to newly emerging virus variants. Here we have used the filamentous fungus expression system Thermothelomyces heterothallica(C1), which has a natural high biosynthesis capacity for secretory enzymes and other proteins further enhanced by genetic engineering of the wild-type fungus, to produce a human monoclonal IgG1 antibody (HuMab 87G7) that neutralises SARS-CoV-2 variants of concern (VOCs) Alpha, Beta, Gamma, Delta, and Omicron. Like its mammalian cell produced equivalent, C1 produced HuMab 87G7 broadly neutralised SARS-CoV-2 VOCs in vitro and it also provided protection against Omicron and Delta VOCs in both hamsters and non-human primates, respectively. The only notable difference between the two versions was their N-linked glycosylation patterns detected by glyoproteomic analysis. Taken together, these findings demonstrate potential of the C1 expression system as a promising technology platform for the development of HuMabs in preventive and therapeutic medicine.
Risk factors for neonatal hypoxic ischemic encephalopathy and therapeutic hypothermia: a matched case-control study
Authors: Roto Suoma , Nupponen Irmeli , Kalliala Ilkka , Kaijomaa Marja 
Published: June 2023

Abstract

Background
Peripartum asphyxia is one of the main causes of neonatal morbidity and mortality. In moderate and severe cases of asphyxia, a condition called hypoxic-ischemic encephalopathy (HIE) and associated permanent neurological morbidities may follow. Due to the multifactorial etiology of asphyxia, it may be difficult prevent, but in term neonates, therapeutic cooling can be used to prevent or reduce permanent brain damage. The aim of this study was to assess the significance of different antenatal and delivery related risk factors for peripartum asphyxia, associated HIE and the need for therapeutic hypothermia.
Methods
We conducted a retrospective matched case-control study in Helsinki University area hospitals during 2013–2017. Newborn singletons with moderate or severe HIE and the need for therapeutic hypothermia were included. Study cases were identified from the hospital database using ICD-codes P91.00, P91.01 and P91.02. For every newborn with the need for therapeutic hypothermia the consecutive term singleton newborn matched by gender, fetal presentation, delivery hospital, and the mode of delivery was selected as a control. Odds ratios (OR) between obstetric and delivery risk factors and the development of HIE were calculated.
Results
Eighty-eight cases with matched controls met the inclusion criteria during the study period. Maternal and infant characteristics among cases and controls were similar, but smoking was more common among cases (aOR 1.46, CI 1.14–1.64, p = 0.003). The incidence of preeclampsia, diabetes and intrauterine growth restriction in groups was equal. Induction of labour (aOR 3.08, CI 1.18–8.05, p = 0.02) and obstetric emergencies (aOR 3.51, CI 1.28–9.60, p = 0.015) were more common in the case group. No difference was detected in the duration of the second stage of labour or the delivery analgesia.
Conclusions
Smoking, induction of labour and obstetric emergencies, especially shoulder dystocia, increase the risk for HIE and need for therapeutic hypothermia. The decisions upon induction of labour need to be carefully weighed, since maternal smoking and obstetric emergencies can hardly be controlled by the clinician.
A systematic review of inherited retinal dystrophies in Pakistan: Updates from 1999 to April 2023
Authors: Munir Asad , Afsar Salma , Rehman Atta Ur 
Published: June 2023

Abstract

Background Inherited retinal degenerations (IRDs) are a group of rare genetic conditions affecting retina of the eye that range in prevalence from 1 in 2000 to 1 in 4000 people globally. This review is based on a retrospective analysis of research articles reporting IRDs associated genetic findings in Pakistani families between 1999 and April 2023. Methods Articles were retrieved through survey of online sources, notably, PubMed, Google Scholar, and Web of Science. Following a stringent selection criterion, a total 126 research articles and conference abstracts were considered. All reported variants were cross-checked and validated for their correct genomic nomenclature using different online resources/databases, and their pathogenicity scores were explained as per ACMG guidelines. Results A total of 359 sequence variants in 89 distinct genes, previously known to cause IRDs, were uncovered. In around 70% cases, parents of the index patient were consanguineously married, and approximately 90% of the detected variants were found in a homozygous state. Overall, more than 95% of the IRDs cases were recessively inherited. Missense variants were predominant (43%), followed by frameshift (26%), nonsense (18.7%), splice site (12%) and synonymous change (< 1%). Non-syndromic IRDs were significantly higher than syndromic IRDs (77% vs. 23%). Retinitis pigmentosa (RP) was the most frequently observed IRD followed by Leber’s congenital amaurosis (LCA). Altogether, mutations inPDE6Agene was the leading cause of IRDs in Pakistani families followed by mutations inTULP1gene. Conclusion In summary, Pakistani families are notable in expressing recessively inherited monogenic disorders including IRDs likely due to the highest prevalence of consanguinity in the country that leads to expression of pathogenic variants in homozygous state.
The art of childbirth in the midwife of al-Andalus: social assessment, legal implication and health assistance in the cultural diversity of the 10th-14th centuries
Authors: Espina-Jerez Blanca , Aguiar-Frías Ana María , Siles-González José , Gómez-Cantarino Sagrario 
Published: June 2023

Abstract
Background
The women of al-Andalus were the result of Arabization and Islamization in Spain. In the 10th-14th centuries, there was great cultural diversity in the territory. The historiography of Andalusian women is very recent. The figures of woman physician and midwife existed for female care and performed various functions. Existing studies do not address care in a focused manner, including the professionalization of the trade, requirements, intervention areas, treatments, among others.
Objective
To analyse the care provided by Andalusian midwives, justifying the importance of their role and profession in the diversity of the Andalusian community during the 10th-14th centuries.
Methods
A scoping review was conducted following the Dialectical Structural Model of Care (DSMC). Six thematic blocks were established, and a database search was conducted for the period 2013–2022. Primary medical and legislative sources were used.
Results
Two types of midwife or qābila were found, one professional and the other an experienced elderly woman. There was also the woman physician or ṭabība who acted as a midwife. All had different training and attended as obstetricians and paediatricians. They were highly valued socially and were the only female professions that required qualified training. Exceptionally, names of known care providers were presented. They performed their legal function exceptionally in the courts, with various activities related to the care framework. They assisted in gestation, childbirth, and the postpartum period for the woman and the newborn, and worked with the wet nurse. In their work, tools to facilitate childbirth and medication for this and other female intervention circumstances were found. They participated in postpartum rituals, and their interventions were accompanied by a folk framework. Remedies for fertility, contraception, and abortion were also found.
Conclusions
There was great inequality inherent in patriarchal societies in academic training, knowledge transmission, and care. Midwives worked in a segregated domestic space and also in the legal area. They moved without restrictions in public spaces to reach another woman's home and meet a care need. With this, they safeguarded the rules of sexual segregation and female limits. They acted as public care providers for the community diversity of the 10th-14th centuries.
Emergence of Urban Heat Traps from the Intersection of Human Mobility and Heat Hazard Exposure in Cities
Authors: Huang Xinke , Mostafavi Ali , Jiang Yuqin 
Published: June 2023

Abstract
Understanding the relationship between spatial structures of cities and environmental hazard exposures (such as urban heat) is essential for urban health and sustainability planning. However, a critical knowledge gap exists in terms of the extent to which socio-spatial networks shaped by human mobility exacerbate or alleviate urban heat exposures of populations in cities. In this study, we utilize location-based data to construct human mobility networks in twenty metropolitan areas in the U.S. The human mobility networks are analyzed in conjunction with the urban heat characteristics of spatial areas. We identify areas with high and low urban heat exposure and evaluate visitation patterns of populations residing in high and low urban heat areas to other spatial areas with similar and dissimilar urban heat exposure. The results reveal the presence of urban heat traps in the majority of the studied metropolitan areas in which populations residing in high heat exposure areas primarily visit areas with high heat exposure. The results also show a small percentage of human mobility to produce urban heat escalate (visitations from low heat areas to high heat areas) and heat escapes (movements from high heat areas to low heat areas). The findings from this study provide a better understanding of urban heat exposure in cities based on patterns of human mobility. These finding contribute to a broader understanding of the intersection of human network dynamics and environmental hazard exposures in cities to inform more integrated urban design and planning to promote health and sustainability.
Re-irradiation of In- or Out-of-PTV Esophageal Recurrence after Definitive Chemoradiotherapy for Esophageal Squamous Cell Carcinoma
Authors: Liu Ming , Chen Yun , Liu Qi , Han Xu , Huang Zike , Sun Lining , Fan Min , Lai Songtao , Wu Kailiang , Zhu Zhengfei , Yang Huanjun , Ai Dashan , Zhu Hongcheng , Deng Jiaying , Su Fengtao , Zhao Kuaile 
Published: June 2023

Abstract
PURPOSE
To compare the clinical characteristics, toxicity and efficacy of re-irradiation between locoregional esophageal recurrence within and outside the initial PTV (Planning target volume) after definitive chemoradiotherapy for ESCC (esophageal squamous cell carcinoma).
MATERIALS AND METHODS
Patients receiving re-irradiation for esophageal recurrence three months after definitive chemoradiotherapy for ESCC were retrospectively analyzed. Patients were divided into in- and out-of-PTV recurrence groups depending on the recurrent lesion center within or outside the initial PTV. The clinical characteristics, toxicities and efficacy of re-irradiation were compared between these two groups.
RESULTS
116 eligible patients from June 2009 to October 2019 were analyzed with 68 patients in the in-PTV group and 48 in the out-of-PTV group. The median initial radiation dose was 61.2 Gy in both groups. 39 patients (57.4%) in the in-PTV group and 28 patients (58.3%) in the out-of-PTV group received chemoradiotherapy in salvage treatment, while the others received re-irradiation only. The median re-irradiation doses were 50.4 Gy and 60 Gy in the in- and out-of-PTV groups, respectively. The median survival times were 9.9 months and 31.8 months in the in-PTV and out-of-PTV groups (P < 0.001), respectively, with 2-year local control rates 10.7% and 56.9% (P < 0.001). The rates of esophageal perforation in the in-PTV and out-of-PTV groups were 8.8% and 4.2% during or after re-irradiation, respectively, with esophageal hemorrhage (≥ grade 3) 11.8% and 0%.
CONCLUSION
Patients with out-of-PTV esophageal recurrence are different from in-PTV recurrence with the better safety, radiosensitivity and efficacy of re-irradiation after definitive chemoradiotherapy.
Revitalizing Strong Cultural Connections and Resilience: Co-Designing a Pilot Elder-Led Mentorship Program for Indigenous Mothers in a Remote Northern Community in Alberta, Canada
Authors: Fitzpatrick Kayla M , Montesanti Stephanie , Verstraeten Barbara S.E , Tourangeau Beverly , Albert Lorraine , Oster Richard T 
Published: June 2023

Abstract

Background:Connection to traditional knowledge and culture is important for promoting Indigenous parental well-being and fostering healthy environments for child development. Historical and modern injustices have resulted in a loss of culture, language, identity, spiritual and traditional practices in birth and parenting for many Indigenous peoples across the globe. Community Elders in a remote northern community in Alberta, Canada, and researcher allies collaborated to design a pilot Elders Mentoring Program to support Indigenous mothers(-to-be) and bring back cultural traditions, teachings and Indigenous knowledge on motherhood.Methods:Community-based participatory research principles guided all aspects of the research partnership. Elders and researchers organized 12 workshops with Indigenous mothers(-to-be) centred on traditional activities including beading, sewing, and medicine picking in conjunction with traditional knowledge transfer and cultural teachings from Elders on aspects of well-being. An explanatory mixed methods study design was used for this project. Quantitative data was collected from surveys completed by the mothers (n=9) at the start of the program about perinatal and postpartum health experience, determinants of care needs, and aspects of resilience of Indigenous mothers. To capture the Elders and mothers’ experiences from their participation in the project, qualitative data was collected using a sharing circle with Elders and individual debrief conversations with mothers. Survey responses were analysed descriptively and sharing circles and debrief conversations were analysed using thematic content analysis.Results:Survey results showed limited availability of services, transportation and access to childcare as factors determining access and utilisation of perinatal and postpartum services and programs. Four themes emerged from qualitative data analysis: (1) the meaningful role of Elder mentorship for Indigenous mothers(-to-be); (2) weekly workshops provided a safe space to share and develop peer-to-peer relationships; (3) passing on of traditional stories and skills during participation in cultural activities fostered positive coping and self-esteem among the Elders and mothers; (4) Elder-led workshops encouraged culture and language revitalization and passing on of tradition to younger generations. The project was positively perceived by Elders and mothers who participated.Conclusions:The findings demonstrated that Elder-led cultural workshops promoted cultural connectedness and enhanced resilience for mothers(-to-be) in a remote northern Indigenous community.
Genomic and epigenomic insights into the mechanism of cold response in upland cotton (Gossypium hirsutum)
Authors: Wang Junduo , Liang Yajun , Gong Zhaolong , Zheng Juyun , Li Zhiqiang , Zhou Guohui , Li Xueyuan , Xu Yuhui 
Published: June 2023

Abstract
Functional genome research, including gene transcriptional and posttranslational modifications of histones, can benefit greatly from a high-quality genome assembly. Histone modification plays a significant role in modulating the responses to abiotic stress in plants. However, there are limited reports on the involvement of dynamic changes in histone modification in cold stress response in cotton. In this study, the genome of an elite accession, YM11, with considerable cold stress resistance was de novo assembled, which yielded a genome of 2343.06 Mb with a contig N50 of 88.96 Mb, and a total of 73,821 protein-coding gene models were annotated. Comparisons among YM11 and five Gossypium allopolyploid cotton assemblies highlighted a large amount of structural variations and presence/absence variations. We analyzed transcriptome and metabolome changes in YM11 seedlings subjected to cold stress. Using the CUT&Tag method, genome-wide H3K3me3 and H3K9ac modification patterns and effect of histone changes on gene expression were profiled during cold stress. Significant and consistently changing histone modifications and the gene expressions were screened, of which transcription factors (TFs) were highlighted. Our results suggest a positive correlation between the changes in H3K4me3, H3K9ac modifications and cold stress-responsive gene activation. This genome assembly and comprehensive analysis of genome-wide histone modifications and gene expression provide insights into the genomic variation and epigenetic responses to cold stress in upland cotton.
Surface Modification of Biomass and Enhancing Sorption Capacity of Azo-dyes
Authors: PATIL JAGADISH H , Kusanur Raviraj , Jain Pulkit , R Abhishek , Nagar Manav 
Published: June 2023

Abstract
The effectiveness of citric acid modified biomasses Rice Husk (RH) and Water Hyacinth (WH) in removing Congo Red (CR) dye from its aqueous solution was studied. The modified biosorbents were characterized using FTIR and SEM. The optimum conditions of parameters- pH, adsorption time and adsorbent dosage, were evaluated using Box-Behnken Design (BBD) and Response Surface Methodology (RSM) to maximize dye removal. For WH the optimum removal was 91.4% in time 22.649 minutes, at pH of 2.0 and adsorbent dosage of 0.198 g for 20mL of dye, which was obtained with a regression coefficient R2 value of 0. 9905. Whereas for RH the optimum was 88.204% removal in 34.048 minutes, at pH of 2.0 and adsorbent dosage of 0.189 g in 20mL of dye with R2 value of 0.9828. The model of the mechanism of adsorption and the multi-factor interactions were arrived at through statistical modelling and testing of the adsorption equilibrium data. Overall, this research focuses on sustainable and effective methods for removing Congo Red dye from water using modified agricultural waste biomass.