bluuebunny/crossref_metadata_2025_split huggingface dataset:
(176) THE PREVALENCE OF SEXUAL DYSFUNCTIONS IN IRAN DURING 2008-2017
Authors: Dr. Mohsen Ghorbani , Prof. Mahnoosh Foroughi 
Published: July 2023

Abstract

Objectives
The sexual issues education is a forgotten subject in Iran. With consideration of the significance role of sexual health in the quality of life, different types of sexual dysfunctions are common problems in Iran. The aim of this study is to determine the prevalence of different kinds of sexual dysfunctions.

Methods
All published Iranian articles with keywords of “sex” or “sexual dysfunction” in Google Scholar and interior databases (same as governmental reports) during 2008-2017 have been reviewed. Regarding to criteria, 32 studies were selected. Cause of heterogeneity was evaluated by meta-regression model.

Results
With consideration of inclusion and exclusion criteria, 32 studies with 16750 persons were completed. The prevalence of female sexual dysfunction was 67.9% and male sexual dysfunction was 58.2%. Overall prevalence has been increased significantly in recent years. Also the sexual satisfaction has very poor condition.

Conclusions
This meta-analysis study shows us a comprehensive view about sexual problems in Iran and suggests that Iranian population don’t have a suitable condition in sexual health. Further studies for detection of etiologic factors may be necessary.

Conflicts of Interest
Our abstract is free commercial influence or bias.
(158) FEMALE STUDENTS OF PHYSIOTHERAPY AND DYSPAREUNIA
Authors: Gabrijela Simetinger , Darija Scepanovic , Boni Peterle 
Published: July 2023

Abstract

Objectives
Since sexuality is still a taboo in most Slovenian faculties pelvic floor physiotherapy and its sexual function are not included in physiotherapy curriculum. The aim of the study was to find out how much female students of physiotherapy suffering from dyspareunia actually know about it.

Methods
Qualitative study included in-depth interviews with female students of physiotherapy with dyspareunia regarding their problem and awareness about it. A total of 20 semi-structured in-depth interviews with students from 4 different Slovenian faculties were carried out between April 2021 and July 2021.

Results
Results show that students with dyspareunia most often feel pain at the entrance of vagina during sexual intercourse. Interviewees have a negative physical and psychological experience during painful sexual intercourse. They feel fear and/or shame and try to avoid sexual intercourse. They attribute the cause of pain to the size of the penis, sexual position, partner’s excessive sexual desire and partner’s physical and psychological violence. Six students never talk about pain with their partners. They rather confide in friends. Half of the students believe dyspareunia is curable and mention that professional help is needed but less than a half have actually sought it. Ten students asked gynaecologists for help. They suggested alternative sexual positions and lubricants without giving them basic information on dyspareunia, only two were satisfied with counselling. Despite the pain interviewees continue having sexual intercourse and use alternative methods. Six students consider dyspareunia a normal part of sexual intercourse and do not see it as a sexual dysfunction.

Conclusions
Pelvic floor physiotherapy and its sexual function are still not included in the physiotherapist education programme in Slovenia, consequently female students of physiotherapy are not aware of the importance pelvic floor muscles have in maintaining sexual function.

Conflicts of Interest
No conflict of interest.
(283) LEVERAGING REAL WORLD EVIDENCE FOR NEGLECTED MEDICAL NEEDS: PUTTING WOMEN’S NEEDS AT THE CENTRE OF A DIGITAL HEALTH APPLICATION DEVELOPMENT
Authors: Kronthaler Selina M , Dr. Anna Tatzber , Eden Kosman , Prof. Klaus M Beier , Dr. Laura Hatzler 
Published: July 2023

Abstract

Objectives
Although a large number of women affected by sexual dysfunctions seek medical help, their needs are barely addressed in the health care system. Regulatory pathways are key for the translation of real world evidence into accessible personalized health care solutions. Since 2019 the Digital Healthcare Act creates a pathway in Germany for the development and reimbursement of digital tools collecting patient-reported outcome measures (PROMs), patient-reported experience measures (PREMs) and product's meta-data. The purpose of this study is to develop a mobile digital intervention for women with gynecological conditions and sexual distress.

Methods
Women with sexual distress participate in the iterative process during the software and content development of a mobile digital application. Health care needs, relevance of therapeutic content, desired outcomes and exercises for sexual distress, partner involvement, integration of health care professionals and dissemination strategies are addressed in qualitative interviews and focus groups including up to 50 women. Results will be validated in user testings. Additionally, prototypes of the app will be tested for usability and feasibility with affected women.

Results
The preliminary results show the outcomes of qualitative research and active patient involvement to design a digital therapy for women with sexual pain disorders. The findings have an important impact on the iterative development of the software, the content and the regulatory pathway of the application. Furthermore the results are translated into a study design which meets the requirements of innovative regulatory and reimbursement pathways in Germany.

Conclusions
The findings show how to translate women’s need into patient-centered therapy and how to tailor a digital intervention to target outcomes which are relevant to women affected by sexual distress. Evidence based research implemented in innovative regulatory pathways has potential to give rise to value based health solutions.

Conflicts of Interest
-
(278) WOMEN AFTER CANCER: CAN WE IMPROVE SEXUAL ATTITUDES? EVALUATION OF A PILOT WORKSHOP
Authors: Dr. Alba Bartolomé 
Published: July 2023

Abstract

Objectives
The aim was to evaluate the effect of a workshop for sexual health promotion on sexual attitudes among oncological women.

Methods
Eleven women who had had an oncological process attended a two-days (4-hours) pilot workshop for promotion of sexual health in Hospital 12 de Octubre, in Madrid, in June 2022. Before the first session, patients answered a scale to evaluate “sexual attitudes in oncological women” designed for this study (not validated). Seven of these women came back to the second session and fulfilled the same scale at the end of the workshop.
The “Sexual Attitudes in Oncological Women Scale” consisted of 20 items, answered with a likert-scale. Total score ranged from 20 to 100. Questions explored attitudes after cancer towards sexual health, sexual relationships, consent, pleasure, desire, body image, sexual diversity and communication about sex issues with professionals and partner.

Results
Women were 36 to 62 years old (median 49.5 years), all Caucasian but one Hispanic and 9 had had breast cancer, one lung cancer and one metastatic.
Total score pre-intervention ranged from 66 to 87 (mean score 77). Total score post-intervention ranged from 73 to 99 (mean 84).
Mean increase in total score after intervention was 6.9 points (standard deviation 6.1), ranging from 3 to 18 points. Just one woman had the same score and none of them had a lower one. Figure 1 shows changes in mean total score.

Conclusions
A validated scale to measure sexual attitudes in women after cancer could be very useful to evaluate interventions in this field. Although this one is not validated, the fact that all women raised their score after the intervention suggests a change towards more positive attitudes about sexuality among this group of oncological women after this workshop.
Further studies are needed to validate these results as well as an appropriated scale.

Conflicts of Interest
The authors report no conflicts of interest.
(324) HEALTH INSURANCE COVERAGE AND OTHER BARRIERS TO CONTRACEPTIVE USE AMONG WOMEN WITH UNPLANNED PREGNANCY
Authors: Dr. Clair Enthoven , Prof. Hanan El Marroun , Dr. Jeremy Labrecque , Prof. Nicole Lucassen , Prof. Marco Varkevisser , Dr. Femke Truijens , Hilmar Bijma , Prof. Pauline Jansen 
Published: July 2023

Abstract

Objectives
In 2004, contraception was removed from the national public health insurance fund for women aged &gt;21 years in the Netherlands. The objectives of this study were: 1) to determine the association of birth control coverage on contraceptive use and unplanned pregnancies; 2) to assess the sociodemographic characteristics of women with unplanned pregnancy who did and did not use contraception five years preceding pregnancy; and 3) to explore what role women themselves attribute to the use of contraception in unplanned pregnancies.

Methods
Data from the population-based birth cohort Generation R of pregnant women with delivery dates between 2002 and 2006 (N=7424), and data from 10 semi-structured interviews among women with (a history of) an unplanned pregnancy was used. Logistic, multinomial regression analyses and thematic analyses were performed.

Results
Of the women with unplanned pregnancy (29.3%), 80.4% used contraception in the five years prior to pregnancy, and 13.8% used contraception in the month of conception. Age ≥35 years, migration background, being married and a household income of ≤€2000/month were associated with not using contraception in the last five years. The prevalence of unplanned pregnancy did not differ before and after the policy change in 2004, but women with unplanned pregnancy less likely used contraception after the policy change (OR=0.59; 95%CI=0.35-0.97) in sensitivity analyses. Thematic analyses revealed that resistance against (hormonal) contraception because of side effects or negative stories, not being able to take hormonal contraception due to medical reasons or currently not having a partner were prominent arguments for not using contraception.

Conclusions
Within our sample of pregnant women, health insurance coverage did not affect the prevalence of unplanned pregnancy, but it may influenced the use of contraception. Dissatisfaction with the current available birth control options may be an important argument that needs more attention in future studies.

Conflicts of Interest
The authors do not have any conflict of interest regaring this study.
(223) PERCEPTION OF SIGNALS OF SEXUAL INTEREST IN PATIENTS WITH SCHIZOPHRENIA
Authors: Paula Biedková , Ondřej Novák , Filip Španiel , Renáta Androvičová 
Published: July 2023

Abstract

Objectives
Patients with schizophrenia (SCH) commonly report difficulties in forming sexual partnerships. Surprisingly, there is very little research addressing this phenomenon. To fill this knowledge gap, we aim to identify the underlying factors of these difficulties. We will test first, whether patients detect and recognize signals of sexual interest, second, whether these signals are sexually salient to them, and third, whether patients can adequately respond to these signals.

Methods
Sample: Thirty male patients with schizophrenia and a control group of the same size, matched for demographic parameters, will be recruited from the Study of first episodes of schizophrenia (ESO, National Institute of Mental Health Czech Republic). ESO is an extensive prospective database dedicated to the longitudinal follow-up of first-episode patients with SCH, which contains a wealth of information on bio-psycho-social markers. Procedure: We will test variables of interest using an experiment developed in our laboratory, which depicts male and female actors showing behavioral displays conveying signals of a) sexual interest, b) neutral but friendly attitude, and c) aversive attitude towards an observer. Statistical analysis: We will use a multivariate linear mixed model regression analysis. Group and a type of behavioral signal will serve as predictors, and physiological, psychological and behavioral responses of patients and control subjects will function as dependent variables. The model will be enriched by including several covariates, most importantly hormonal markers.

Results
Currently, data are being collected.

Conclusions
Our study will identify whether difficulties in forming sexual partnerships reported by patients with SCH could be connected to a compromised ability of patients to detect, interpret and respond to signals of sexual interest. Our findings could lead to the development of sexual remediation strategies. To our best knowledge, no such instrument is available for patients with SCH. This project is funded by the Czech Health Research Council, registration number NU21J-04-00024.

Conflicts of Interest
All authors declare that they have no conflicts of interest.
(321) CONTRIBUTIONS OF DYADIC APPROACHES TO THE PSYCHOSOCIAL ADAPTATION OF COUPLES TO PROSTATE CANCER: A SCOPING REVIEW PROTOCOL
Authors: Rita Castro , Sonia Pieramico , Sandra Aguiar , Francisca Bismarck , Diana Ferreira , Inês Tavares , Prof. Joana Carvalho , Prof. Ana Q Gomes , Prof. Pedro Nobre 
Published: July 2023

Abstract

Objectives
Prostate cancer is the second most prevalent cancer diagnosed in men around the world. The available treatments have negative side effects on the mental and sexual health of patients, but also their partners. There is evidence of the relevance of taking dyadic approaches to the study of relational stress that chronic diseases bring to couples’ dynamics. Although, less is known about the application of dyadic approaches to the psychosocial adaptation to prostate cancer. Despite the recent increase of studies conducted with both patients and partners, there are different approaches used. The goal of this scoping review is to map and summarize the evidence of existing dyadic studies that examine the psychosocial adaptation of couples to prostate cancer.

Methods
To this end, we are conducting a systematic search of studies published from 2005 to September 2022 on electronic databases (Scopus, Web of Science, PubMed, Cochrane, and EBSCOHost), with the following search terms “prostat* cancer” OR “prostat* carcinoma” OR “prostat* tumor” OR “prostat* adenocarcinoma” OR “prostat* neoplasia” OR “pca” AND “dyad*” OR “couple*” OR “partner*” OR “spouse” OR “caregiver*” OR “APIM” OR “Actor Partner Interdependence Model” OR “Actor Partner” OR “Actor Partner Model” AND “psychosocial” OR “pychology*” OR “impact” OR “mental health” OR “sexual health” OR “adaptati*”. This review follows the PRISMA guidelines.

Results
This work will give, researchers on prostate cancer and professionals working on oncological care, an overview of the potential use of dyadic approaches to help with the psychosocial adaptation of couples’ mental and sexual health during prostate cancer.

Conclusions
The present work strengthens the need to do more research on how couples adapt together to prostate cancer diagnosis and treatments and to raise awareness among professionals to include both patients and partners and their needs in the interventions to promote mental and sexual health recovery after the prostate cancer journey.

Conflicts of Interest
All the authors declare no known conflict of interest. This project is funded by Horizonte Europa (NORTE-01-0145-FEDER-000057) and by Fundação para a Ciência e Tecnologia (2022.11670.BD.).
(113) SEXUAL ASPECTS OF PREGNANCY AND THE POSTPARTUM PERIOD IN LESBIAN WOMEN
Authors: Højgaard Dr Astrid D , Prof. Bente Dahl , Sam Geuens , Dr. Woet Gianotten 
Published: July 2023

Abstract

Objectives
The presentation aims at presenting knowledge on aspects on sexual function and relationship in lesbian women when reproduction is the matter.
Secondly, we demonstrate our opinion on necessary knowledge for midwives as presented in the chapter “Sexual aspects of pregnancy and the postpartum period in lesbian women” in the open access textbook ‘Sexuality & Midwifery’, published by Springer Nature. The presentation covers topics relevant in lesbian motherhood regarding fertility treatment, pregnancy, delivery, postpartum and period. It is our hope to integrate HCPs with recent knowledge and skills from sexology, providing an overview of the current scientific knowledge on sexuality and aspects related to midwifery when having a consultation with a lesbian couple and how to give good care to and communicate with the lesbian couple.

Methods
A review of current literature on lesbian motherhood, prevalence, marital and reproductive rights and treatments, the role of the co-mother and sexological counselling focusing on lesbians.

Results
Sexuality and sexual orientation should be an issue in all maternity care areas in midwifery and gyn/obs education. Health professionals should bear in mind that not all women are heterosexual – if you do not ask – patients probably do not tell. Particular attention to verbal and non-verbal language and asking direct questions to both partners is important to make the co-mother feeling acknowledged as parents and not overlooked or invisible. Many problems are common pregnancy or postpartum issues for heterosexual couples as well. Be also aware not to focus too much on the sexual orientation of the lesbian woman or couple. Not all minority women are victimised and oppressed, but many women are in some world regions.

Conclusions
All HCPs should be aware of their own assumptions, attitudes, and cultural bias. Meeting the minority woman/couple with an open mind and heart can be a most rewarding experience.

Conflicts of Interest
None
(190) URETHRAL RECONSTRUCTIVE SURGERY IN TRANSGENDER PATIENTS UNDERGOING PHALLOPLASTY: A CASE REPORT
Authors: Alonso-Bartolomé María B , Esaú Fernández , Andrea Rodríguez , Santiago Alonso-Bartolomé , Carlos Toribio-Vázquez 
Published: July 2023

Abstract

Objectives
Transgender patients are those whose sexual identity differs from the anatomical sex with which they were born. More and more patients are looking for medical and surgical treatment to achieve the desired sex. These surgeries may have some urethral complications that urologists must be aware of and be able to treat them. The aim of this study is to present the case of a patient with several urethral complications after phalloplasty surgery.

Methods
Phalloplasty consists of removing the female genital tract and creating neo-male genitalia with autologous grafts. In our center, phalloplasty is performed using a radial forearm microsurgical free-flap with double tunneling, in two stages.
The resulting urethra consists of a pars fixa, obtained from the tubulization of the labia minora, and a pars pendulans, formed by tubulized forearm skin.
The most common urethral complications are urethrocutaneous leaks and fistulas (15-70%), especially in the two anastomotic areas; the persistence of the vaginal cavity; and urethral strictures (up to 41%). Most of these complications can be resolved conservatively or surgically.

Results
We present the case of a trans male who, after the first stage of phalloplasty, developed a pars fixa fistula, successfully managed conservatively. After its resolution, the second time was performed with a radial forearm microsurgical free-flap. In the immediate postoperative period, the patient required several reinterventions due to flap congestion. He developed a fistula and stricture in the new urethral anastomosis, requiring a two-stage urethroplasty with a dorsal buccal mucosa graft. After this procedure, urethral integrity was achieved with spontaneous micturition through the phallus.

Conclusions
Phalloplasty must be carried out by a multidisciplinary team that involves plastic and urology services. It is an increasingly frequent surgery, so mastery of the anatomy of these reconstructions by the urologist is essential to solve any complications.

Conflicts of Interest
No.
Proportionality rhetoric and neoliberal rationality in the ‘fundamental social rights’ adjudication of the Court of Justice of the European Union
Authors: Garcia Blesa Juan J 
Published: July 2023

Abstract
This article studies the rhetorical construction of proportionality discourse in controversial social rights cases at the Court of Justice of the European Union. It argues that neoliberal rationality controls the Court’s proportionality discourse. That rationality operates through eliding social conflict and excluding egalitarian approaches to social rights, which are rhetorically re-imagined as subsidiary instruments of competition and business.
Recent oncolytic virotherapy clinical trials outline a roadmap for the treatment of high-grade glioma
Authors: Bernstock Joshua D , Blitz Sarah E , Hoffman Samantha E , Gerstl Jakob V E , Chiocca E Antonio , Friedman Gregory K 
Published: July 2023

Abstract
Adult and pediatric high-grade gliomas (HGGs) are aggressive cancers of the central nervous system that confer dismal clinical prognoses. Standard radiation and chemotherapy have demonstrated only limited efficacy in HGGs, motivating the accelerated investigation of novel modalities such as oncolytic virus (OV) therapies. OV centered therapies work through a mixed mechanism centered on oncolysis and the stimulation of an antitumor immune response. Three recent clinical trials utilizing herpes simplex virus-1 and adenovirus-based oncolytic virotherapy demonstrated not only the safety and efficacy of OVs but also novel dosing strategies that augment OV response potential. Considering these recent trials, herein we present a roadmap for future clinical trials of oncolytic immunovirotherapy in both adult and pediatric HGG, as well as persistent roadblocks related to the assessment of OV efficacy within and between trials.
Prevalence of pathogenic germline variants in adult-type diffuse glioma
Authors: McDonald Malcolm F , Prather Lyndsey L , Helfer Cassandra R , Ludmir Ethan B , Echeverria Alfredo E , Yust-Katz Shlomit , Patel Akash J , Deneen Benjamin , Rao Ganesh , Jalali Ali , Dhar Shweta U , Amos Chris I , Mandel Jacob J 
Published: July 2023

Abstract

Background
No consensus germline testing guidelines currently exist for glioma patients, so the prevalence of germline pathogenic variants remains unknown. This study aims to determine the prevalence and type of pathogenic germline variants in adult glioma.

Methods
A retrospective review at a single institution with paired tumor/normal sequencing from August 2018–April 2022 was performed and corresponding clinical data were collected.

Results
We identified 152 glioma patients of which 15 (9.8%) had pathogenic germline variants. Pathogenic germline variants were seen in 11/84 (13.1%) of Glioblastoma, IDH wild type; 3/42 (7.1%) of Astrocytoma, IDH mutant; and 1/26 (3.8%) of Oligodendroglioma, IDH mutant, and 1p/19q co-deleted patients. Pathogenic variants in BRCA2, MUTYH, and CHEK2 were most common (3/15, 20% each). BRCA1 variants occurred in 2/15 (13%) patients, with variants in NF1, ATM, MSH2, and MSH3 occurring in one patient (7%) each. Prior cancer diagnosis was found in 5/15 patients (33%). Second-hit somatic variants were seen in 3/15 patients (20%) in NF1, MUTYH, and MSH2. Referral to genetics was performed in 6/15 (40%) patients with pathogenic germline variants. 14/15 (93%) of patients discovered their pathogenic variant as a result of their paired glioma sequencing.

Conclusions
These findings suggest a possible overlooked opportunity for determination of hereditary cancer syndromes with impact on surveillance as well as potential broader treatment options. Further studies that can determine the role of variants in gliomagenesis and confirm the occurrence and types of pathogenic germline variants in patients with IDH wild type compared to IDH mutant tumors are necessary.