bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global analysis of benthic complexity in shallow coral reefs
Authors: Li Jiwei , Asner Gregory P 
Published: February 2023

Abstract
Three-dimensional shallow benthic complexity (also known as benthic rugosity) reflects the physical conditions of shallow coral reefs environments and can be used to estimate fish biomass and coral cover on reefs. Spatially explicit data on benthic complexity could offer critical information for coral reef conservation and management. However, benthic complexity has not yet been mapped at a global scale. We mapped global shallow water benthic complexity to 20 m depth at a spatial resolution of 10 m using 22 000 Sentinel-2 satellite images and a globally applicable underwater algorithm. We quantified geographic variation of benthic complexity in shallow coral reef areas from individual reef to ocean basin scales. We found that shallow benthic complexity is unevenly distributed worldwide, with high benthic complexity regions found in areas known to have high levels of benthic biodiversity such as the Coral Triangle, Coral Sea, and Great Barrier Reef. Yet nearly 60% of detected coral reef regions (size = 61 156 km2) are not listed as protected under current marine protected plans. These unprotected regions include substantial reef areas of high benthic complexity that may harbor high levels of biodiversity. Our global coral reef benthic complexity map supports plans to improve marine protected areas, reef conservation, and management.
Three billion new trees in the EU’s biodiversity strategy: low ambition, but better environmental outcomes?
Authors: Lee Heera , Pugh Thomas A M , Patacca Marco , Seo Bumsuk , Winkler Karina , Rounsevell Mark 
Published: February 2023

Abstract
The EU Biodiversity strategy aims to plant 3 billion trees by 2030, in order to improve ecosystem restoration and biodiversity. Here, we compute the land area that would be required to support this number of newly planted trees by taking account of different tree species and planting regimes across the EU member states. We find that 3 billion trees would require a total land area of between 0.81 and 1.37 Mha (avg. 1.02 Mha). The historic forest expansion in the EU since 2010 was 2.44 Mha, meaning that despite 3 billion trees sounding like a large number this target is considerably lower than historic afforestation rates within the EU, i.e. only 40% of the past trend. Abandoned agricultural land is often proposed as providing capacity for afforestation. We estimate agricultural abandoned land areas from the HIstoric Land Dynamics Assessment+ database using two time thresholds (abandonment since 2009 or 2014) to identify potential areas for tree planting. The area of agricultural abandoned land was 2.6 Mha (potentially accommodating 7.2 billion trees) since 2009 and 0.2 Mha (potentially accommodating 741 million trees) since 2014. Our study highlights that sufficient space could be available to meet the 3 billion tree planting target from abandoned land. However, large-scale afforestation beyond abandoned land could have displacement effects elsewhere in the world because of the embodied deforestation in the import of agricultural crops and livestock. This would negate the expected benefits of EU afforestation. Hence, the EU’s relatively low ambition on tree planting may actually be better in terms of avoiding such displacement effects. We suggest that tree planting targets should be set at a level that considers physical ecosystem dynamics as well as socio-economic conditions.
Multi-hop quantum teleportation of an arbitrary two-qubit state based on hierarchical simultaneous entanglement swapping
Authors: Wu Fan , Bai Ming-Qiang , Tang Liang , Mo Zhi-Wen 
Published: February 2023

Abstract
Combined with hierarchy simultaneous entanglement swapping, the scheme of the multi-hop quantum teleportation (QT) is proposed by using multi-pair Bell states. The scheme consists of two levels based on simultaneous entanglement swapping, namely Level-1 and Level-2. The former realizes simultaneous entanglement swapping of the inner segment, while the latter completes simultaneous entanglement swapping of the inter segment. Besides, the effect of four different types of noise (phase-damping, amplitude-damping, phase-flip, and bit-flip noise) on our scheme is analyzed by calculating the fidelity and concurrence. The results indicate that the fidelity and concurrence are related to the amplitude parameter, decoherence rate and number of nodes. Furthermore, compared with the scheme of the multi-hop QT adopting simultaneous entanglement swapping, our scheme can greatly reduce classical communication cost, and shows that the optimal classical communication cost can be obtained by selecting different segmentation methods.
Hybrid quantum–classical convolutional neural networks with privacy quantum computing
Authors: Huang Siwei , Chang Yan , Lin Yusheng , Zhang Shibin 
Published: February 2023

Abstract
Machine learning algorithms help us discover knowledge from big data. Data used for training or prediction often contain private information about users. Discovering knowledge while protecting data or user privacy is the way machine learning is expected, especially in the cloud environment. Quantum machine learning is a kind of machine learning that realizes parallel acceleration by quantum superposition. Quantum computing power for quantum machine learning is typically provided by quantum cloud computing services. Existing quantum machine learning algorithms hardly consider privacy protection. This paper presents an encryption method for image data which can effectively protect the input data privacy in hybrid quantum–classical convolutional neural networks algorithm. The user’s original image data is first encrypted, and then sent to the quantum cloud to calculate the image convolution. By doing so, the feature map of the ciphertext image is obtained by the user. The result obtained by decrypting the feature map is the same as that obtained by using the original image as the input of convolution calculation. Experiments show that our privacy protection scheme can protect the privacy of input image data in the hybrid quantum–classical neural networks algorithm, but does not affect the accuracy of the algorithm. In addition to image encryption and feature map decryption, the proposed scheme does not bring additional computational complexity.
Validating EEG source imaging using intracranial electrical stimulation
Authors: Unnwongse Kanjana , Rampp Stefan , Wehner Tim , Kowoll Annika , Parpaley Yaroslav , von Lehe Marec , Lanfer Benjamin , Rusiniak Mateusz , Wolters Carsten , Wellmer Jörg 
Published: February 2023

AbstractElectrical source imaging is used in presurgical epilepsy evaluation and in cognitive neurosciences to localize neuronal sources of brain potentials recorded on EEG. This study evaluates the spatial accuracy of electrical source imaging for known sources, using electrical stimulation potentials recorded on simultaneous stereo-EEG and 37-electrode scalp EEG, and identifies factors determining the localization error. In 11 patients undergoing simultaneous stereo-EEG and 37-electrode scalp EEG recordings, sequential series of 99–110 biphasic pulses (2 ms pulse width) were applied by bipolar electrical stimulation on adjacent contacts of implanted stereo-EEG electrodes. The scalp EEG correlates of stimulation potentials were recorded with a sampling rate of 30 kHz. Electrical source imaging of averaged stimulation potentials was calculated utilizing a dipole source model of peak stimulation potentials based on individual four-compartment finite element method head models with various skull conductivities (range from 0.0413 to 0.001 S/m). Fitted dipoles with a goodness of fit of ≥80% were included in the analysis. The localization error was calculated using the Euclidean distance between the estimated dipoles and the centre point of adjacent stimulating contacts. A total of 3619 stimulation locations, respectively, dipole localizations, were included in the evaluation. Mean localization errors ranged from 10.3 to 26 mm, depending on source depth and selected skull conductivity. The mean localization error increased with an increase in source depth (r(3617) = [0.19], P = 0.000) and decreased with an increase in skull conductivity (r(3617) = [−0.26], P = 0.000). High skull conductivities (0.0413–0.0118 S/m) yielded significantly lower localization errors for all source depths. For superficial sources (&lt;20 mm from the inner skull), all skull conductivities yielded insignificantly different localization errors. However, for deeper sources, in particular &gt;40 mm, high skull conductivities of 0.0413 and 0.0206 S/m yielded significantly lower localization errors. In relation to stimulation locations, the majority of estimated dipoles moved outward-forward-downward to inward-forward-downward with a decrease in source depth and an increase in skull conductivity. Multivariate analysis revealed that an increase in source depth, number of skull holes and white matter volume, while a decrease in skull conductivity independently led to higher localization error. This evaluation of electrical source imaging accuracy using artificial patterns with a high signal-to-noise ratio supports its application in presurgical epilepsy evaluation and cognitive neurosciences. In our artificial potential model, optimizing the selected skull conductivity minimized the localization error. Future studies should examine if this accounts for true neural signals.
Gasdermin D represses inflammation-induced colon cancer development by regulating apoptosis
Authors: Tanaka Shigekazu , Orita Hajime , Kataoka Taro , Miyazaki Masahiro , Saeki Harumi , Wada Ryo , Brock Malcolm V , Fukunaga Tetsu , Amano Takanori , Shiroishi Toshihiko 
Published: February 2023

Abstract
Chronic inflammation is widely recognized as a major risk factor for cancer formation, but the underlying mechanisms are poorly understood. Recently, it was shown that Gasdermin D (GSDMD) protein drives pyroptotic cell death in macrophages on cleavage by inflammatory caspases. Even though the Gsdmd gene is specifically expressed in the intestinal epithelium, the role of Gsdmd in the intestinal tissues remains poorly characterized. In this study, we examined the biological role of Gsdmd in colorectal cancer (CRC) development, employing an azoxymethane/dextran sulfate sodium carcinogenesis model. Results show that GSDMD deficiency enhances CRC development, probably due to decreased apoptosis caused by downregulation of interferon-gamma (IFNγ)—signal transducer and activator 1 (STAT1) signaling. Furthermore, we show that GSDMD protein is diminished in human colorectal cancer, indicating involvement of GSDMD in repression of CRC development in humans. Our findings provide a new insight into functions of Gsdmd/GSDMD in colonic inflammation and human CRC development.
Effect and mechanisms of dexmedetomidine combined with macrophage migration inhibitory factor inhibition on the expression of inflammatory factors and AMPK in mice
Authors: Chen Siyu , Wu Jianjiang , Li Aimei , Huang Yidan , Tailaiti Taiwangu , Zou Tiantian , Jiang Jin , Wang Jiang 
Published: February 2023

AbstractReperfusion after acute myocardial infarction can cause ischemia/reperfusion (I/R) injury, which not only impedes restoration of the functions of tissues and organs but may also aggravate structural tissue and organ damage and dysfunction, worsening the patient’s condition. Thus, the mechanisms that underpin myocardial I/R injury need to be better understood. We aimed to examine the effect of dexmedetomidine on macrophage migration inhibitory factor (MIF) in cardiomyocytes from mice with myocardial I/R injury and to explore the mechanistic role of adenosine 5ʹ-monophosphate-activated protein kinase (AMPK) signaling in this process. Myocardial I/R injury was induced in mice. The expression of serum inflammatory factors, reactive oxygen species (ROS), adenosine triphosphate (ATP), and AMPK pathway-related proteins, as well as myocardial tissue structure and cell apoptosis rate, were compared between mice with I/R injury only; mice with I/R injury treated with dexmedetomidine, ISO-1 (MIF inhibitor), or both; and sham-operated mice. Dexmedetomidine reduced serum interleukin (IL)-6 and tumor necrosis factor-α concentrations and increased IL-10 concentration in mice with I/R injury. Moreover, dexmedetomidine reduced myocardial tissue ROS content and apoptosis rate and increased ATP content and MIF expression. MIF inhibition using ISO-1 reversed the protective effect of dexmedetomidine on myocardial I/R injury and reduced AMPK phosphorylation. Dexmedetomidine reduces the inflammatory response in mice with I/R injury and improves adverse symptoms, and its mechanism of action may be related to the MIF-AMPK pathway.
Risk of Acute Myocardial Infarction Among Patients With Laboratory-Confirmed Invasive Pneumococcal Disease: A Self-Controlled Case Series Study
Authors: Wiese Andrew D , Mitchel Ed , Ndi Danielle , Markus Tiffanie M , Talbot H Keipp , Schaffner William , Grijalva Carlos G 
Published: February 2023

Abstract

Background
Acute myocardial infarction (AMI) events have been reported among patients with certain viral and bacterial infections. Whether invasive pneumococcal disease (IPD) increases the risk of AMI remains unclear. We examined whether laboratory-confirmed IPD was associated with the risk of AMI.

Methods
We conducted a self-controlled case series analysis among adult Tennessee residents with evidence of an AMI hospitalization (2003–2019). Patient follow-up started 1 year before the earliest AMI and continued through the date of death, 1 year after AMI, or study end (December 2019). Periods for AMI assessment included the 7 to 1 days before IPD specimen collection (pre-IPD detection), day 0 through day 7 after IPD specimen collection (current IPD), day 8 to 28 after IPD specimen collection (post-IPD), and a control period (all other follow-up). We used conditional Poisson regression to calculate incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for each risk period compared with control periods using within-person comparisons.

Results
We studied 324 patients hospitalized for AMI with laboratory-confirmed IPD within 1 year before or after the AMI hospitalization. The incidence of AMI was significantly higher during the pre-IPD detection (IRR, 10.29; 95% CI: 6.33–16.73) and the current IPD (IRR, 92.95; 95% CI: 72.17–119.71) periods but nonsignificantly elevated in the post-IPD risk period (IRR, 1.83; 95% CI: .86–3.91) compared with control periods. The AMI incidence was higher in the post-IPD control period (29 to 365 days after IPD; IRR, 2.95; 95% CI: 2.01–4.32).

Conclusions
Hospitalizations with AMI were strongly associated with laboratory-confirmed IPD.
What is the significance of the Hill classification?
Authors: Brännström Lisa , Werner Mårten , Wallner Bengt , Franklin Karl A , Karling Pontus 
Published: February 2023

Summary
This study aimed to investigate the significance of Hill classification to predict esophagitis, Barrett’s esophagus, gastroesophageal reflux disease (GERD) symptomatology, and future prescriptions of proton pump inhibitors in clinical practice. A total of 922 patients (546 women and 376 men; mean age 54.3 [SD 18.4] years) who underwent gastroscopy between 2012 and 2015 were analyzed. Patient questionnaire regarding symptoms were compared with endoscopy findings. A medical chart review was done that focused on the prescription of PPIs, additional gastroscopies, and GERD surgery in a 3-year period before the index gastroscopy and in a 6-year period afterward. In patients naïve to PPI prescriptions (n = 466), Hill grade III was significantly associated with esophagitis (AOR 2.20; 95% CI 1.00–4.84) and &gt; 2 PPI prescriptions 6 year after the index gastroscopy (AOR 1.95; 95% CI 1.01–3.75), whereas Hill grade IV was significantly associated with esophagitis (AOR 4.41; 95% CI 1.92–10.1), with Barrett’s esophagus (AOR 12.7; 95% CI 1.45–112), with reported heartburn (AOR 2.28; 95% CI 1.10–4.74), and with &gt;2 PPI prescriptions (AOR 2.16; 95% CI 1.02–4.55). In patients ‘non-naïve’ to PPI prescription (n = 556), only Hill grade IV was significantly associated with esophagitis, reported heartburn, and with &gt;2 PPI prescriptions. The gastroscopic classification in Hill grades III and IV is important in clinical practice because they are associated with esophagitis, Barrett’s esophagus, symptoms of GERD, and prescriptions of PPIs, whereas a differentiation between Hill grades I and II is not.
What would a pluralist institutional approach to constitutional interpretation look like? Some methodological implications
Authors: De Visser Maartje , Neo Jaclyn L 
Published: February 2023

Abstract
This article makes the case for adopting a genuinely pluralist perspective when studying constitutional interpretation and sets out the principal forms such inquiries can take. While it has now been accepted that the court-centricity that characterized much of the earlier work on constitutional interpretation must be recalibrated, the approach taken in much constitutional scholarship remains underinclusive, as the role of executives, agencies, ad hoc commissions, and social actors in constructing the meaning of the constitutional text is often downplayed, or altogether overlooked. We argue that a pluralist perspective is necessary to fully appreciate the practice of constitutionalism in each jurisdiction and enable more informed analyses of the relationship between constitutions and law-making. Through a series of case studies, we further demonstrate that, while nonjudicial interpretation is an important practice in all countries, such a perspective could be particularly apposite in dominant-party states, as well as those favoring political constitutionalism, where courts are unlikely to position themselves as the principal, let alone exclusive, authority on what the constitution means. This article also explores the methodological implications in designing pluralistic constitutional interpretation studies, focusing on the questions that await investigation, the core variables at play, and the particular hazards in collating and assessing the materials that must be reckoned with.
The therapeutic threshold in clinical decision-making for TB
Authors: de Rooij Madeleine L , Lynen Lutgarde , Decroo Tom , Henriquez-Trujillo Aquiles R , Boyles Tom , Jacobs Bart K M 
Published: February 2023

Abstract
Because TB control is still hampered by the limitations of diagnostic tools, diagnostic uncertainty is common. The decision to offer treatment is based on clinical decision-making. The therapeutic threshold, test threshold and test-treatment threshold can guide in making these decisions. This review summarizes the literature on methods to estimate the therapeutic threshold that have been applied for TB. Only five studies estimated the threshold for the diagnosis of TB. The therapeutic threshold can be estimated by prescriptive methods, based on calculations, and by descriptive methods, deriving the threshold from observing clinical practice. Test and test-treatment thresholds can be calculated using the therapeutic threshold and the characteristics of an available diagnostic test. Estimates of the therapeutic threshold for pulmonary TB from intuitive descriptive approaches (20%–50%) are higher than theoretical prescriptive calculations (2%–3%). In conclusion, estimates of the therapeutic threshold for pulmonary TB depend on the method used. Other methods exist within the field of decision-making that have yet to be implemented or adapted as tools to estimate the TB therapeutic threshold. Because clinical decision-making is a core element of TB management, it is necessary to find a new, clinician-friendly way to unbiasedly estimate context-specific, agreed upon therapeutic thresholds.
Repeat-associated non-AUG translation in neuromuscular diseases: mechanisms and therapeutic insights
Authors: Fujino Yuzo , Mori Kohji , Nagai Yoshitaka 
Published: February 2023

Summary
Expanded short tandem repeats cause more than 50 monogenic diseases, which are mostly neuromuscular diseases. In the non-coding repeat expansion diseases, in which the expanded repeat sequence is located outside of the coding region, the toxicity of the transcribed repeat-containing RNAs had been the focus of research. However, recent studies have revealed that repeat RNAs can be translated into repeat polypeptides, despite the lack of an AUG initiation codon, by non-canonical repeat-associated non-AUG translation (RAN translation). RAN translated repeat polypeptides have actually been confirmed in patients’ tissues. Moreover, various cellular and animal disease models have demonstrated the toxicity of these peptides, suggesting the pathogenic roles of RAN translation in the repeat expansion diseases. In this review, we will outline RAN translation, from the viewpoint of its molecular mechanisms to its potential as a therapeutic target for the repeat expansion diseases.
Acetophenone and Green Leaf Volatiles Do Not Enhance the Efficacy of Verbenone for Inhibiting Attraction of Ips pini (Coleoptera: Curculionidae) to Pheromone-baited Traps in Northern Arizona
Authors: Gaylord Monica L , Audley Jackson P , McMillin Joel D , Fettig Christopher J 
Published: February 2023

Abstract
We assessed attraction of pine engraver, Ips pini (Say) (Coleoptera: Curculionidae; Scolytinae), to pheromone-baited funnel traps treated with repellent semiochemicals in ponderosa pine, Pinus ponderosa var. scopulorum Engelm., forests in northern Arizona. Treatments included: 1) baited control (B, ipsdienol + lanierone), 2) 70 g of SPLAT Verb (a flowable, biodegradable formulation containing 10% verbenone, ISCA Technologies Inc., Riverside, CA, USA) + B, 3) 70 g of SPLAT Verb + (E)-2-hexen-1-ol+(Z)-2-hexen-1-ol + acetophenone + B, 4) 7.84-g verbenone pouch (Product #3413, Synergy Semiochemicals Corp., Delta, British Columbia, Canada) + B, and 5) 7.84-g verbenone pouch + (E)-2-hexen-1-ol+(Z)-2-hexen-1-ol + acetophenone + B. In total, 472 I. pini were collected. Trap catches were highest in baited traps and declined significantly with the addition of both formulations of verbenone. Traps treated with SPLAT Verb caught significantly fewer I. pini and male I. pini than those treated with verbenone pouches. The addition of (E)-2-hexen-1-ol+(Z)-2-hexen-1-ol + acetophenone to SPLAT Verb and the verbenone pouch had no effect on trap catch. Verbenone has potential as an effective tool for protecting P. ponderosa trees and slash from I. pini in northern Arizona, but the addition of (E)-2-hexen-1-ol+(Z)-2-hexen-1-ol + acetophenone to verbenone is unwarranted.