bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanographene‐Based Decoration as a Panchromatic Antenna for Metalloporphyrin Conjugates
Authors: Garcia‐Orrit Saül , Vega‐Mayoral Victor , Chen Qiang , Serra Gianluca , Paternò Giuseppe M. , Cánovas Enrique , Narita Akimitsu , Müllen Klaus , Tommasini Matteo , Cabanillas‐González Juan 
Published: June 2023

AbstractPorphyrins, a type of heterocyclic aromatic compounds consisting of tetrapyrroles connected by four substituted methine groups, are appealing building blocks for solar energy applications. However, their photosensitization capability is limited by their large optical energy gap, which results in a mismatch in absorption toward efficient harvesting of the solar spectrum. Porphyrin π‐extension by edge‐fusing with nanographenes can be employed for narrowing their optical energy gap from 2.35 to 1.08 eV, enabling the development of porphyrin‐based panchromatic dyes with an optimized energy onset for solar energy conversion in dye‐sensitized solar fuel and solar cell configurations. By combining time‐dependent density functional theory with fs transient absorption spectroscopy, it is found that the primary singlets, which are delocalized across the entire aromatic part, are transferred into metal centred triplets in only 1.2 ps; and subsequently, relax toward ligand‐delocalized triplets. This observation implies that the decoration of the porphyrin moiety with nanographenes, while having a large impact on the absorption onset of the novel dye, promotes the formation of a ligand‐centred lowest triplet state of large spatial extension, potentially interesting for boosting interactions with electron scavengers. These results reveal a design strategy for broadening the applicability of porphyrin‐based dyes in optoelectronics.
A Self‐Assembly Nano‐Prodrug for Combination Therapy in Triple‐Negative Breast Cancer Stem Cells
Authors: Wu Chongzhi , Zhang Fu , Li Bowen , Li Zhiyao , Xie Xin , Huang Yong , Yao Zhuo , Chen Yuan , Ping Yuan , Pan Weidong 
Published: June 2023

AbstractTriple‐negative breast cancer (TNBC) displays a highly aggressive nature that originates from a small subpopulation of TNBC stem cells (TNBCSCs), and these TNBCSCs give rise to chemoresistance, tumor metastasis, and recurrence. Unfortunately, traditional chemotherapy eradicates normal TNBC cells but fails to kill quiescent TNBCSCs. To explore a new strategy for eradicating TNBCSCs, a disulfide‐mediated self‐assembly nano‐prodrug that can achieve the co‐delivery of ferroptosis drug, differentiation‐inducing agent, and chemotherapeutics for simultaneous TNBCSCs and TNBC treatment, is reported. In this nano‐prodrug, the disulfide bond not only induces self‐assembly behavior of different small molecular drug but also serves as a glutathione (GSH)‐responsive trigger in controlled drug release. More importantly, the differentiation‐inducing agent can transform TNBCSCs into normal TNBC cells, and this differentiation with chemotherapeutics provides an effective approach to indirectly eradicate TNBCSCs. In addition, ferroptosis therapy is essentially different from the apoptosis‐induced cell death of differentiation or chemotherapeutic, which causes cell death to both TNBCSCs and normal TNBC cells. In different TNBC mouse models, this nano‐prodrug significantly improves anti‐tumor efficacy and effectively inhibits the tumor metastasis. This all‐in‐one strategy enables controlled drug release and reduces stemness‐related drug resistance, enhancing the chemotherapeutic sensitivity in TNBC treatment.
Mesoscopic 3D Charge Transport in Solution‐Processed Graphene‐Based Thin Films: A Multiscale Analysis
Authors: Boschi Alex , Kovtun Alessandro , Liscio Fabiola , Xia Zhenyuan , Kim Kyung Ho , Avila Samuel Lara , De Simone Sara , Mussi Valentina , Barone Carlo , Pagano Sergio , Gobbi Marco , Samorì Paolo , Affronte Marco , Candini Andrea , Palermo Vincenzo , Liscio Andrea 
Published: June 2023

AbstractGraphene and related 2D material (GRM) thin films consist of 3D assembly of billions of 2D nanosheets randomly distributed and interacting via van der Waals forces. Their complexity and the multiscale nature yield a wide variety of electrical characteristics ranging from doped semiconductor to glassy metals depending on the crystalline quality of the nanosheets, their specific structural organization ant the operating temperature. Here, the charge transport (CT) mechanisms are studied that are occurring in GRM thin films near the metal‐insulator transition (MIT) highlighting the role of defect density and local arrangement of the nanosheets. Two prototypical nanosheet types are compared, i.e., 2D reduced graphene oxide and few‐layer‐thick electrochemically exfoliated graphene flakes, forming thin films with comparable composition, morphology and room temperature conductivity, but different defect density and crystallinity. By investigating their structure, morphology, and the dependence of their electrical conductivity on temperature, noise and magnetic‐field, a general model is developed describing the multiscale nature of CT in GRM thin films in terms of hopping among mesoscopic bricks, i.e., grains. The results suggest a general approach to describe disordered van der Waals thin films.
The dynamic versus the stable team: The unspoken question in large‐scale agile development
Authors: Ståhl Daniel 
Published: June 2023

SummaryThe importance of the team, its internal dynamics, and its performance are widely recognized within the software engineering community. While popular frameworks identify wholeness, stability over time, and smallness as important factors, they offer little guidance on how to form teams that achieve these three characteristics. The objective of this study is to investigate how these team characteristics interact in large‐scale software development contexts, particularly focusing on the impact of stable and dynamic teaming approaches. This was done through a multivocal study of literature, followed by individual semi‐structured interviews with 19 engineers from two companies and validation workshops with an additional two companies from unrelated industry segments. The study results show that the question of stable versus dynamic approaches to forming software engineering teams is largely unaddressed in industry, with stable teams representing a habitual default option. Meanwhile, both stable and dynamic teams clearly have respective strengths and weaknesses, calling for careful consideration of the most suitable approach in any given situation. To support such consideration, this paper presents a model of how team stability, wholeness, and smallness interact. This model is found relevant, accurate, generalizable, and useful by practitioners.
Recent Progress of Advanced Materials for Triboelectric Nanogenerators
Authors: Liu Di , Zhang Jiayue , Cui Shengnan , Zhou Linglin , Gao Yikui , Wang Zhong Lin , Wang Jie 
Published: June 2023

AbstractTriboelectric nanogenerators (TENGs) have received intense attention due to their broad application prospects in the new era of internet of things (IoTs) as distributed power sources and self‐powered sensors. Advanced materials are vital components for TENGs, which decide their comprehensive performance and application scenarios, opening up the opportunity to develop efficient TENGs and expand their potential applications. In this review, a systematic and comprehensive overview of the advanced materials for TENGs is presented, including materials classifications, fabrication methods, and the properties required for applications. In particular, the triboelectric, friction, and dielectric performance of advanced materials is focused upon and their roles in designing the TENGs are analyzed. The recent progress of advanced materials used in TENGs for mechanical energy harvesting and self‐powered sensors is also summarized. Finally, an overview of the emerging challenges, strategies, and opportunities for research and development of advanced materials for TENGs is provided.
Development and validation of high‐performance thin layer chromatographic method for simultaneous quantitation of novel combination perindopril erbumine and moxonidine hydrochloride
Authors: Akabari Ashok H , Surati Jasmina , Patel Sagar , Pathak Bhumin , Patel Arun , Patel Chandani , Patel Sagarkumar K 
Published: June 2023

AbstractThe primary purpose of the present study was to develop and validate a high‐performance thin‐layer chromatography method for quantitatively determining an anti‐hypertensive agent, perindopril erbumine, and moxonidine hydrochloride in bulk and synthetic mixture. The densitometric procedure was performed on aluminum thin‐layer chromatography plates pre‐coated with silica gel 60F254, employing a combination of dichloromethane: toluene: methanol: ammonia (7:1:2:0.1 v/v/v/v) as the mobile phase. The thin‐layer chromatography scanner was operated in absorbance mode at a wavelength of 223 nm to evaluate densitograms. The linearity of the method was established in the range of 1000–5000 ng/band for perindopril erbumine and 40–200 ng/band for moxonidine hydrochloride; the correlation coefficient (r2) was 0.9993 and 0.9983, respectively. The values of a limit of detection (186.06 and 3.51 ng/band, respectively, for perindopril erbumine and moxonidine hydrochloride) and limit of quantification (620.23 and 11.73 ng/band, respectively, for perindopril erbumine and moxonidine hydrochloride) have demonstrated the sensitivity of the developed method. The reported process was precise in both intra‐day and inter‐day analysis; the percentage relative standard deviation of peak area was less than 2% and has an accuracy within 100 ± 2%. The developed method has the potential to quantify perindopril erbumine and moxonidine hydrochloride from its synthetic mixture without any interference from other components or in quality control laboratories.
Multinationals from emerging economies: Strategies, challenges, and the way forward
Authors: Rasheed Abdul A. , Ahmed Zafar U. 
Published: June 2023

AbstractMultinationals from emerging economies are relatively new players in the global economy. This Special Issue includes five articles that cover several important aspects of the market and nonmarket strategies pursued by emerging market multinational corporations (EMNCs). Given that only a few firms from emerging markets embrace the possibilities and challenges of going global, we highlight the need to examine country, industry, and firm level antecedents of the emergence of EMNCs. We also draw attention to the need to study the role played by immigrant populations in EMNC internationalization.
Goreisan alleviates cerebral edema: Possibility of its involvement in inhibiting aquaporin‐4 function
Authors: Shimizu Tomofumi , Murakami Kazuhito , Matsumoto Chinami , Kido Toshitaka , Isohama Yoichiro 
Published: June 2023

AbstractAimIn Japan, goreisan (GRS) is used to alleviate cerebral edema and relieve headaches. Although improvement of water maldistribution in the brain may be one of the mechanisms of action of GRS for cerebral edema and headache, scientific evidence is limited. Here, we aimed to investigate the action mechanism of GRS against cerebral edema and headaches, focusing on water dynamics in the brain.MethodsWe used a well‐established mouse model of cerebral edema to evaluate the effects of GRS on related symptoms and brain water content. The mouse model was subjected to magnetic resonance imaging (MRI) using H217O to assess water dynamics in the brain. The effect of GRS on water permeability through aquaporin‐4 (AQP4) was also examined in vitro.ResultsGRS inhibited the loss of righting reflex and improved survival in the mouse model by ameliorating the increase in brain water content. The MRI evaluation of water dynamics suggested that GRS inhibited water influx into the brain. Evaluation of water permeability via AQP4 in Xenopus laevis oocytes and HEK293 cells showed that GRS inhibited AQP4 function.ConclusionGRS suppressed the ubiquity of water in the brain in a mouse model of cerebral edema, suggesting inhibition of AQP4 function (not AQP4 expression) as one of the action mechanisms of GRS. Our findings provide fundamental evidence for the clinical efficacy of GRS against cerebral edema and headaches.
Introduction
Authors: Lambert Laurent A. , Elayah Moosa 
Published: June 2023

AbstractTwenty years after the terror attacks of 9/11/2001, the world witnessed the humiliating withdrawal of US troops from Afghanistan under the ‘protection’ of the new rulers of Kabul, the Taliban. The introduction to this book sheds light on the background of two decades of ‘War on Terror’ (WoT), a loose umbrella term for many US armed conflicts abroad—some still ongoing—, and reviews major publications on the WoT. It then explains this book’s focus on what has happened in the region to explainwhythe US formidable mobilization of means and might has transformed into such a blatant geostrategic defeat. This is a particularly timely task as we are entering, we argue, the era of a post-American Middle East.
Numerical Simulation on Smoke Control for Extra-Long Tunnel Fires
Authors: Liu Wenbo , Li Junmei , Li Yanfeng 
Published: June 2023

AbstractBased on an actual project in Beijing, this article investigates the effect of smoke control strategies on smoke extraction efficiency under different fire source locations of the point smoke extraction system in extra-long tunnels using Airpak software. The results show that when a fire occurs in a tunnel, the smoke extraction efficiency of the tunnel smoke extraction system varies greatly depending on the location of the fire source and the adoption of different smoke extraction strategies. Due to the suction of the smoke exhaust shaft fan, the relative distance between the electric smoke exhaust valve and the entrance of the tunnel is close, which will cause the smoke exhaust valve within a certain range to be plug-holing, seriously affecting the smoke exhaust effect of the smoke exhaust system. Smoke exhaust valve beyond this range, although not occurring plug-holing the smoke exhaust efficiency is also relatively low, by changing the opening strategy of the smoke exhaust valve can effectively improve the smoke exhaust valve plug-holing, so as to improve the smoke exhaust efficiency.
Study on Failure Process of Freeze–Thaw Fractured Rock Under Multistage Cyclic Loads
Authors: Peng Liu 
Published: June 2023

AbstractIn order to further study the failure characteristics of freeze-thawed rocks in the alpine region under multistage cyclic loads, a numerical simulation analysis was carried out with RFPA2D software, taking the natural fractured granite from the Beizhan Iron Mine in Hejing County, Xinjiang Province as an example. The results show that the degree of natural fracture determines the fracture form of rock, and when the degree of natural fracture is large, the rock will eventually undergo shear slip failure along the natural fracture. When natural fissure rock is subjected to load, its initial structural deterioration occurs at the fissure, and tensile failure occurs. When the natural fracture expands to a certain extent, the rock begins to undergo large-scale compressive shear failure, which eventually leads to shear-slip failure of the fractured rock. The failure mode of fractured rock is affected by the degree of fracture development, the degree of penetration and the inclination Angle.
Numerical Simulation for the Dynamic Response of Step Topography Subjected to Blasting Load
Authors: Yang Lixiang , Han Yaobin , Zhang Xu , Li Zhiwen 
Published: June 2023

AbstractThe vibration velocity and frequency of rock mass are closely related to the instability and failure of the building. The step topography has great influence on blasting vibration wave propagation. Therefore, it is of great significance to study the dynamic response of step topography subjected to blasting load. In this paper, the FLAC2D program is used to study the dynamic response of step topography subjected to blasting load. The plane strain mode is adopted in the calculation, and the blasting load is assumed to be a triangular pulse wave which is applied to one side of the calculating mode. The amplification effect of the height of the step is first studied. The calculation result shows that the amplification factor increases first and then decreases with the increase of the step height. The maximum value of the amplification factor is consistent with the results of the field test, which indicates the feasibility of the numerical simulation.
Research on Numerical Simulation Analysis and Engineering Application of Prestressed Anchor Cable Construction
Authors: Zhu Yanfang , Xiong Bing 
Published: June 2023

AbstractThe prestressed anchor cable can improve the overall stability of the rock and soil mass of the slope, thereby improving the mechanical properties of the rock and soil mass, and can better control the structural displacement, and achieve the purpose of reducing landslides, dangerous rocks and dangerous rocks. At the same time, the pre-stressed anchor cable construction is convenient, fast in progress, and economical, and has a broad application space. Based on the actual engineering background, this paper analyzes the key technologies in the construction process, and uses finite element software to conduct an overall numerical analysis of the soil after the use of prestressed anchor cables. It analyzes the impact of different slope top loads and finds that for non-prestressed anchor rods, the depth of action is limited, excessively increasing their length will not only cause difficulties in construction, but also have no practical significance. When prestress is applied, the horizontal displacement of the baffle is not uniform under the action of different prestress and slope top load, showing a twisting phenomenon. Along with the increase of the slope top load, the lateral pressure also increases, which causes the displacement of the baffle to decrease with the increase of the slope top load. The research in this paper will have certain guiding significance for the engineering application of prestressed anchor cables.
Study on Fatigue Performance of Typical Fatigue Detail in Orthotropic Steel Deck
Authors: Yan Bing , Zhu Yaoyu , Meng Cheng , Yuanzhou Zhiyuan 
Published: June 2023

AbstractOrthotropic steel decks (OSDs) are easily subjected to fatigue cracking under the cyclic vehicle loading, and arc notch between diaphragm and U-rib is one of the typical fatigue details. The strain values of three measuring points at arc notch in a steel bridge were monitoring to obtain the stress time histories. Then, fatigue stress amplitudes and fatigue damage degrees were analysed. It was found that this typical fatigue detail was under tension–compression cyclic stress. The maximum stress amplitude appeared at U-rib weld toe, which indicated that fatigue cracks were more prone to propagate on this area, comparison of fatigue damage degrees also corroborated it.
Study on Soil Disturbance Caused by Shield Tunneling in Sandy Strata
Authors: Zou Weiyu , Luo Shuyi , Liu Yingcheng , Pan Hong 
Published: June 2023

AbstractShield tunneling and construction in sandy soil have great safety risks, so it is necessary to study the soil disturbance caused by tunneling in sandy soil. However, the law of soil disturbance is still relatively vague, so this paper relies on the actual tunnel project, through high-density, close monitoring; The settlement law of soil around shield tunnel is studied and analyzed. The research shows that the settlement of soil disturbance is basically stable after the shield tail leaves the monitoring section about twice the length of the shield machine; During shield tunneling in sandy strata, the sand on the upper part of the tunnel is very easy to collapse, thus forming a “collapse arch”. The formation of this feature will be one of the reasons for the construction accidents of large diameter shield machines; The remarkable feature of soil disturbance around the tunnel in the water rich sand layer is that the maximum horizontal displacement of the measuring points at different locations occurs at the same depth, and does not develop from the tunnel center to the 45-φ/2 diffusion angle; The maximum horizontal deformation during tunnel construction is far less than the vertical deformation, so the horizontal displacement can be used to better analyze the actual impact of shield construction disturbance.
DSM Based Optimization to the Design Process of Prefabricated Construction
Authors: Yang Xinlong 
Published: June 2023

AbstractThe linear way of prefabricated construction (PC) design can induce extensive occurrence of reworks and increase costs and worktime. To optimize a reasonable and concurrent PC design workflow, a system of detailed PC design processes was built based on literature review and expert investigation. Based on graphic theory and DSM, the interdependent relationships between the processes were confirmed, and clusters of the coupled processes were identified. The paper proposed a model with an improved genetic algorithm to optimize the workflow to reduce rework costs and worktime. Then, a case study is used to estimate the model. The result shows that the optimization can reduce 12% costs and 12.43% worktime, and suggests that the cooperation between work of different design stages needs to be strengthened for a better product and less resource usage. The proposed model can effectively reduce the impact of rework. It improves the optimization methods of PC processes, and is valuable to PC planning and control.
Research on Vibration Signal Characteristics of Multilateral Boundary Deep Hole Blasting
Authors: Chen Junkai , Hao Xiangjun , Wei Zheng , Gao Wenxue , Zhang Xiaojun , Liu Zhaochen 
Published: June 2023

AbstractThe essence of blasting action is the interaction between explosive energy and medium, and the blasting effect depends on the characteristics of explosive energy, medium and interaction law. The multi-boundary comprehensive blasting theory of stonework establishes the functional relationship among boundary conditions, throwing rate and explosive quantity. In this paper, a formula for calculating the explosive charge of multi-boundary deep-hole blasting is put forward, and the experimental study is carried out based on HHT analysis technology. Research shows that: (1) Based on HHT analysis technology, the main frequency of blasting vibration signal energy is in 0–40 Hz, and mainly in low frequency band, while the energy contained in high frequency component gradually decays. (2) Multi-boundary deep-hole controlled blasting has evenly broken rock blocks and all collapsed within the design range, which has achieved good blasting effect.
Study on Design and Application of Ultra-Thin Cover for Noise Reduction and Skid Resistance of Old Cement Concrete Pavement
Authors: Huang Hui , Chen Jie , Zhang Honggang 
Published: June 2023

AbstractAccording to the comparative analysis from the whole life cycle economic cost accounting, the capital investment of preventive maintenance of old cement concrete pavement is less than that of corrective maintenance. Based on the old cement concrete pavement, the problem such as anti-sliding noise, from how to improve the driving comfort and improve the stress of the cement road panel considering structure of old cement concrete pavement preventive maintenance are discussed in this paper, recommend a kind of cement concrete pavement noise reduction against sliding type ultra-thin rubber asphalt surface preventive maintenance structure, It can provide favorable technical reference for the applicability and rational selection of preventive maintenance structure of old cement concrete pavement.