bluuebunny/crossref_metadata_2025_split huggingface dataset:
DAA - directly acting antivirals - as a new, more efficient solution of the chronic hepatitis C treatment and theirs various application.
Authors: Abram Kamila , Banaś Patryk , Adamus Justyna , Pierzchała Jakub Rafał , Bednarz Katarzyna , Sobańska Natalia , Banasiak Aleksandra Paulina , Teichman Rafał , Kasprowicz Jakub , Hyjek Michał 
Published: February 2023

Introduction
Cirrhosis is a condition in which the liver becomes fibrotic following damage to the liver and transforms the architecture of the organ into regenerative nodules. The disease is caused 30% by HCV infection, resulting in a risk of severe complications and death. Since the use of direct-acting antivirals ( DAAs) for the treatment of chronic HCV, sustained virological response (SVR) rates have begun to increase, even in treatment-resistant cases. Studies have also shown that DAAs may have applications in other viral diseases and even In the treatment of breast cancer.

Aim of the study
The purpouse of our study was to review scientific articles to show the efficiency and potential use of DAAs in the treatment of chronic HCV, and to identify possible directions for further research.

Methods and materials
We reviewed the English literature in the PubMed, using the key words: "simeprevir" ; "sofosbuvir" ; "velpatasvir" ; "telaprevir" ; "chronic hepatitis C".

Results
Studies have shown that the therapeutic regimens currently being designed with (DAAs) offer the possibility of treating almost the entire population with hepatitis C, while reducing side effects of interferon therapy such as increased AST, ALT activities, diarrhoea, vomiting, nausea and depression. They remain effective and tolerable, regardless of the stage of cirrhosis and associated serious co-morbidities. Analysis of studiem shows, that DAAs also show efficacy against other disease such as breast cancer, MRSA infections, SARS-CoV-2 or flavivirus infection.

Conclusion
All (DAAs) are effective in the treatment of patients with HCV, including cirrhosis. They result in significant improvements in prognosis and clinical outcomes. Promising results have been obtained in published data on the effect of DAAs against disease entities other than HCV, suggesting the rationale for future clinical trials to further the hypothesis of the increased potential of these drugs.
2022 MCDM Junior Researcher Best Paper Award
Authors: Karpak Birsen 
Published: February 2023

There were five finalists for the 2022 MCDM Junior Researcher Best Paper Award of the MCDM section of INFORMS. Finalists were Sune Lauth Gadegaard, Aarhus University, Denmark; Eleftherios Siskos, Paul Scherrer Institut Switzerland; Merve Bodur, University of Toronto, Canada; and Mohammad Ghaderi, Pompeu Fabra University, Spain (the winner). Jiapeng Liu, Xi’an Jiaotong University, China could not attend the meeting. Roman Słowiński was the 2022 Jury Chair, Poznań University of Technology
All 5 finalists received a diploma at the business meeting of the MCDM Section of INFORMS on October 16, 2022. The winner selected by the Jury was Mohammad Ghaderi. This was a great success for the MCDM/A community to receive ten nominations and to have five finalists for this award!
Dr. Banu Lokman: 2022 Recipient of Prestigious Bernard Roy Award
Authors: Karpak Birsen , Słowiński Roman 
Published: February 2023

It is great pleasure for us to share with the MCDM/A community that Dr. Banu Lokman was the 2022 recipient of prestigious Bernard Roy (BR) award. Dr. Banu Lokman is a Reader in Operational Research at the School of Organisations, Systems and People, University of Portsmouth, UK. We have known Dr. Lokman as an excellent member of the MCDM community for over 10 years and have always thought that she deserves an award. We are very pleased that she was recognized by the EURO Working Group on Multiple Criteria Decision Aiding (EWG MCDA). The award was given during the EWG MCDA business meeting in Agios Nicolaos, Crete last September by Yannis Siskos, the 2022 Jury Chair. Congratulations Dr. Lokman, we are proud of you!
A risk scoring model to predict progression of retinopathy of prematurity for Indonesia
Authors: Siswanto Johanes Edy , Adisasmita Asri C. , Ronoatmodjo Sudarto , Dijk Peter H. , Bos Arend F. , Manurung Florence , Sauer Pieter J. J. 
Published: February 2023

Introduction
Retinopathy of prematurity (ROP) is a serious eye disease in preterm infants. Generally, the progression of this disease can be detected by screening infants regularly. In case of progression, treatment can be instituted to stop the progression. In Indonesia, however, not all infants are screened because the number of pediatric ophthalmologists trained to screen for ROP and provide treatment is limited. Therefore, other methods are required to identify infants at risk of developing severe ROP.

Objective
To assess a scoring model’s internal and external validity to predict ROP progression in Indonesia.

Method
To develop a scoring model and determine its internal validity, we used data on 98 preterm infants with ROP who had undergone one or more serial eye examinations between 2009 and 2014. For external validation, we analyzed data on 62 infants diagnosed with ROP irrespective of the stage between 2017 and 2020. Patients stemmed from one neonatal unit and three eye clinics in Jakarta, Indonesia.

Results
We identified the duration of oxygen supplementation, gestational age, socio-economic status, place of birth, and oxygen saturation monitor setting as risk factors for developing ROP. We developed two models—one based on the duration of supplemental oxygen and one on the setting of the oxygen saturation monitor. The ROP risk and probabilistic models obtained the same sensitivity and specificity for progression to Type 1 ROP. The agreement, determined with the Kappa statistic, between the ROP risk model’s suitability and the probabilistic model was excellent. The external validity of the ROP risk model showed 100% sensitivity, 73% specificity, 76% positive predictive value, 100% negative predictive value, positive LR +3.7, negative LR 0, 47% pre-test probability, and 77% post-test probability.

Conclusion
The ROP risk scoring model can help to predict which infants with first-stage ROP might show progression to severe ROP and may identify infants who require referral to a pediatric ophthalmologist for treatment.
Fostering Skills for Sustainability – Lessons Learnt from Curriculum Design and Learning Outcomes
Authors: Fleacă Bogdan , Fleacă Elena , Maiduc Sanda 
Published: February 2023

Sustainability thinking plays a key role in business development and transformative approach for a safe, sustainable and prosperous future. Education is expected to take action to provide meaningful learning opportunities in different settings and contexts to foster critical thinking thereby understanding the importance of sustainable lifestyles, a climate-neutral economy and a fair society.
Given the increased responsibility of higher education providers for preparing students as future responsible change agents, the study analyzed the curriculum design to foster sustainability skills of students in the particular case of the educational project for cooperation in higher education, implemented from 2020 to 2022. A quantitative survey was conducted aiming at assessing the learners' satisfaction and the fulfillment of learning outcomes, drawing up findings and improvement gaps to facilitate further exploitation of results.
The findings suggested the improvements from one session to another and the positive changes induced through the aid of course objectives, specific learning outcomes, and the correlation between sustainability themes, SDGs topics, and subjects taught. These stimulated the acquisition of knowledge, skills and attitudes toward sustainability as well as hands-on opportunities to change the status quo, to improve teaching and learning, enabling a better alignment of curricula outcomes in the area of business engineering education.
Finally, the authors highlighted the curriculum content and methodological approach may be used and adjusted in different educational settings boosting synergies with other initiatives of a similar nature in other institutional and national contexts.
Keywords: sustainable development, curriculum design, learning outcomes, sustainability skills, quality education
HANSENÍASE EM MENORES DE QUINZE ANOS EM UM MUNICÍPIO HIPERENDÊMICO
Authors: Rocha Camila Beatriz Alves da , Santos Débora Aparecida da Silva , Olinda Ricardo Alves de , Campelo Andréia Maciel Rodrigues , Campos Leonardo José Araujo de , Rossi Elaine Menezes , Goulart Letícia Silveira , Mattos Magda de 
Published: February 2023

Objetivo: Analisar os casos de hanseníase em menores de quinze anos. Métodos: Estudo de campo, quantitativo, transversal, série histórica e descritivo, com 48 casos de hanseníase entre 2009 a 2018 de Rondonópolis (MT). A coleta de dados utilizou prontuários do Serviço de Assistência Especializada e visitas domiciliárias. Foi utilizada estatística descritiva e testes Qui-quadrado e Exato de Fisher; nível de significância de 5%; foi calculada razão de chances e intervalos de confiança. Pesquisa aprovada pelo Comitê de Ética em Pesquisa (CAAE:97441618.2.0000.8088). Resultados: Os casos predominaram em 2013 (18,8%), sexo masculino (52%), faixa etária 10 a 14 anos (54,2%), multibacilar (64,6%) e tuberculóide (64,6%). Foi possível verificar associação estatística significativa entre classe operacional e renda familiar (p<0,0434) e ano de diagnóstico e classificação multibacilar (p<0,0189). Conclusões: O perfil dos casos e os fatores associados indicam alta transmissibilidade da doença e a dificuldade em realização do diagnóstico precoce no município em estudo.
Konsentrasi Fe dan Batas Aman Konsumsi Kerang Hijau (Perna viridis) dari Perairan Tambak Lorok
Authors: Adiningtyas Liningga , Supriyantini Endang , Widowati Ita , Saputri Mimie 
Published: February 2023

Di daerah Tambak Lorok terdapat banyak aktivitas manusia, baik di daratan maupun perairan yang dapat menyebabkan peningkatan konsentrasi logam berat, salah satunya logam Fe. Salah satu organisme yang hidup di Perairan Tambak Lorok dan mampu mengakumulasi logam Fe adalah kerang hijau (Perna viridis). Penelitian ini bertujuan untuk mengetahui kandungan konsentrasi logam berat Fe dalam air, sedimen, dan jaringan lunak daging kerang hijau (P. viridis) serta untuk mengetahui tingkat keamanan konsumsi kerang hijau (P. viridis) harian terhadap logam Fe dari Tambak Lorok, Semarang. Penelitian dilakukan pada bulan Maret dan April 2021 dengan menggunakan metode eksploratif kuantitatif. Kadar logam Fe dianalisis dengan AAS (Atomic Absorption Spectrophotometer). Hasil analisis kandungan logam Fe dalam air berkisar antara 0,16-1,69 mg/L; sedimen 4,39-88,07 mg/kg; dan jaringan lunak kerang hijau (P. viridis) 0,19-2,76 mg/kg. Kandungan logam Fe dalam air menunjukkan peningkatan, sedangkan kandungan Fe dalam sedimen dan jaringan lunak kerang hijau (P. viridis) mengalami penurunan pada bulan April. Nilai BCF (Bioconcentration Factor) < 100 yang menunjukkan akumulasi kerang hijau (P. viridis) terhadap logam Fe rendah. Untuk mengetahui batas aman konsumsi daging kerang hijau per minggu dilakukan penghitungan MTI (Maximum Tolerable Intake). Batas aman konsumsi kerang hijau untuk wanita dengan berat badan 45 kg adalah 657,96 kg/minggu dan 877,28 kg/minggu bagi laki-laki dengan berat badan 60 kg. Many human activities seen in Tambak Lorok, both on land and in waters, may cause an increase in the concentration of heavy metals, such as Fe. One of the organisms that live in Tambak Lorok Waters and are able to accumulate Fe is the green mussels (Perna viridis). This study aims to determine the concentration of Fe in water, sediment, and soft tissue of green mussel (P. viridis) and to determine the safety level of daily consumption of green mussels (P. viridis) against Fe from Tambak Lorok, Semarang. This study was conducted on March and April 2021 using quantitative exploratory methods. The metal content of Fe was analyzed by AAS (Atomic Absorption Spectrophotometer). Fe content in water ranged from 0.16 to 1.69 mg/L; sediment 4.39-88.07 mg/kg; and soft tissue of green mussels (P. viridis) 0.19-2.76 mg/kg. Fe content in water showed an increase, while the Fe content in sediment and soft tissue of green mussels (P. viridis) decreased in April. The BCF (Bio Concentration Factor) value is < 100, which indicates accumulation of green mussels (P. viridis) against Fe metal is low. To determine the safety limit of green mussel consumption per week, MTI (Maximum Tolerable Intake) was calculated. The safety limit for green mussel consumption for women weighing 45 kg is 657,96 kg/week and 877.28 kg/week for men weighing 60 kg.
Japanese complaint responses in textbook dialogues and ordinary conversations: learning objects to expand interactional repertoires
Authors: Arita Yuki , Imamura Akiko 
Published: February 2023

Abstract
This study examines Japanese complaint responses appearing in naturally occurring interaction and textbook dialogues. The comparative analysis highlights that complaint responses in textbooks differ from those in mundane conversation. The inevitable difficulty for textbooks to reflect temporal and multimodal features of interaction results in the designs of affiliative responses being minimal and disaffiliative responses being more explicit. In contrast, conversation data indicates that complaint response turns are more intricately designed with multimodal semiotic resources and are precisely positioned according to the sequential development of complaints. By conducting empirical analyses, the study identifies interactional repertoires that are not observed in textbooks but employed in actual conversations. In doing so, it aims to expand the variety of the analysis of textbook dialogues to help calibrate the input for Japanese language pedagogy, while presenting a reference point for Japanese language learners to better understand the interactional organization of complaint sequences in mundane conversations.
Multiple symmetry protected BIC lines in two dimensional synthetic parameter space
Authors: Zhang Fengyuan , Chu Qiongqiong , Wang Qiang , Zhu Shining , Liu Hui 
Published: February 2023

Abstract
Bound states in the continuum (BICs) have attracted significant interest in recent years due to their unique optical properties, such as infinite quality factor and wave localization. In order to improve the optical performance of BICs based devices, more degrees of freedom are required to tune BICs in high-dimension parameter space for practical applications. To effectively tune more BICs, we form a 2D synthetic parameter space based on a nanohole metasurface array. Multiple symmetry protected BIC modes with high Q factors can be achieved at high-order symmetry point. Through manipulating asymmetry parameters, BIC lines formed by a series of BIC modes can be found in the 2D synthetic parameter space. Moreover, the electric field distributions are investigated to demonstrate the generation and evolution of BICs. By measuring the absorption spectra, the tuning of multiple BICs with synthetic asymmetry parameters is experimentally explored, which agrees well with theoretical results. Therefore, our design can provide new insight for a variety of on-chip applications, such as nonlinear devices, integrated nanolasing array, and high-resolution sensors for infrared molecular detection.
Combination of Digital Image Correlation (DIC) and in situ 3D-μ-CT in the analysis of the relationship between strains and porosity under creep loading
Authors: Camin B. , Hornig-Klamroth J. , zu Bentheim N. 
Published: February 2023

Abstract
In situ 3D μ-XCT allows the time and space resolved measurement and analysis of material damage in the component volume, whereas the Digital Image Correlation (DIC) is a 2D method for the analysis of deformation measured on the surfaces of components. In situ 3D μ-XCT measurements were performed on cylindrical specimen made of SiC particle reinforced titanium MMC (MMC: Metal Matrix Composite) (15 % SiC particles) during creep load. The formation and evolution of voids were subsequently analyzed. Due to the rotationally symmetric sample geometry, the analysis of the deformation in the interior of the material by DIC using 2D slices is possible and evident. The dot pattern required to calculate the strain using DIC (speckle pattern) is provided by the intrinsic particle reinforcement of the MMCs. Temporally and locally changing and time-variant strain fields in both the tensile as well as the compressive range could be detected correlating with void formation and development area.
Imperfections in Inner Cavity of Row 4 Turbine Blade Caused by Metal-Core Reaction
Authors: Neidel A. , Cagliyan E. , Fischer B. 
Published: February 2023

Abstract
When selecting case studies for presentation in this section Failure Analysis of Practical Metallography, the authors of this contribution asked themselves time and again what conditions actually constitute a component failure. Conventional wisdom has it that a failure occurred when a component or assembly lost its function intended by design. The authors readily admit that this is decidedly not the case for the “failure” presented in this contribution. Not only did no failure occur (the component was successfully used in engine service for the intended operating time), but the subject turbine blade did not loose its intended function by any stretch of the imagination. Why is this case study then presented here anyway? Because the evaluation and assessment of severity of indications found upon non-de structive testing of the subject turbine blade was only possible after destructive metallurgical investigation. One could jokingly concede that the blade definitely lost its function after metallographic cut-up. In any case, in the “failure case” presented in this contribution, the engineering department did not dare to release the subject turbine component for renewed engine service after refurbishment, since indications were detected that could not be properly assessed, without destroying the part; hence the subject component was not fit for engine service. The inclined reader may himself decide whether this fact makes it a component failure.
Class of finite-dimensional matrices with diagonals that majorize their spectrum
Authors: Uhlmann Jeffrey 
Published: February 2023

Abstract
We define a special class of finite-dimensional matrices for which the diagonal majorizes the spectrum. This is the first class of matrices known to have this property, although the reverse majorization (i.e., the spectrum majorizing the diagonal) was previously known to hold for unitarily diagonalizable (i.e., normal) matrices. Currently, these are the only known matrix classes that structurally provide a majorization relationship between their spectrum and diagonal.
Rheological Behaviors of Waste Polyethylene Modified Asphalt Binder: Statistical Analysis of Interlaboratory Testing Results
Authors: Wang Di , Baliello Andrea , Pinheiro Gustavo dos Santas , Poulikakos Lily D. , Tušar Marjan , Vasconcelos Kamilla L. , Kakar Muhammad Rafiq , Porot Laurent , Pasquini Emiliano , Giancontieri Gaspare , Riccardi Chiara , Pasetto Marco , Presti Davide Lo , Cannone Falchetto Augusto 
Published: February 2023

Abstract
This article investigated the effect of waste polyethylene (PE) on the modified asphalt binders’ rheological behavior from a statistical point of view. The interlaboratory testing results from the RILEM Technical Committee 279 Valorization of Waste and Secondary Materials for Roads Task Group 1 were used for this purpose. First, an unaged 70/100 penetration graded neat binder was selected as the reference material. Next, a single 5 % content of waste PE additives (PE-pellets and PE-shreds) was mixed with a 95 % neat binder to prepare two PE modified binders. Then, dynamic shear rheometer–based temperature-frequency sweep tests were performed over a wide range of temperatures and frequencies to evaluate the rheological properties of these three binders. Different rheological behaviors were observed in the isochronal plots at high temperatures. Based on a reproducibility precision requirement proposed for phase angle, 28°C was set as the transition temperature across the rheological behaviors. Next, according to the three rheological behaviors defined in a previous study by the authors, statistical analysis was introduced to identify sensitive rheological parameters and determine the thresholds. Results indicate that the phase angle measured above 28°C and 1.59 Hz can be used as a sensitive parameter to discriminate the three rheological behaviors of PE modified binders. The thresholds among different behaviors were also calculated as an example for phase angle measured at the highest common testing temperature of 70°C. Additional experimental evaluations on more types of PE modified binders, especially at intermediate and high temperatures, are recommended to better understand their influence on the rheological behavior of PE modified binders.
Research of a Thermal-Regulation System Using Electronic Integrated Textiles for a Mattress
Authors: Serdar Serap Gamze , Değirmenci Züleyha , Topalbekiroğlu Mehmet 
Published: February 2023

Abstract
With the advent of wearable technology, sleep monitoring has become a common practice. Our performance is significantly impacted by the quantity, efficiency, and quality of our sleep. It proved that temperature has a significant impact on sleep. The temperature circumstance is one of the primary causes of sleep disturbance according to the studies. The purpose of this study is to develop a temperature-controlled mattress system that will improve sleep quality by keeping the temperature within a predetermined range. A scaled prototype was set up and tested. It was found that the mattress system could keep the temperature within the specified range without being influenced by the ambient temperature.
An Electrochemical Approach to Accelerate Mechanically Assisted Crevice Corrosion Damage on Modular Implant Interfaces
Authors: McDermott Eric , Sivan Shiril , Di Prima Matthew 
Published: February 2023

Abstract
Corrosion within the crevice of modular tapers is one of the major mechanisms that leads to orthopedic device failures. However, the currently used fretting corrosion test methods involve extended test durations and are often burdensome. This study evaluates the feasibility of adding micromotion to crevices while being simultaneously subjected to cyclic polarization in order to accelerate corrosion damage. The addition of micromotion was intended to induce crevice and fretting corrosion between metals in a washer-rod combination geometry. Three commonly used orthopedic metals (316L stainless steel, SS316L; grade 5 titanium, Ti6Al4V; and cobalt-chromium-molybdenum per ASTM F1537-20, Standard Specification for Wrought Cobalt-28Chromium-6Molybdenum Alloys for Surgical Implants [UNS R31537, UNS R31538, and UNS R31539], CoCrMo) were used to form crevices in this study to evaluate the test method. A cyclic polarization control group in which no micromotion was present was used to determine the effect of the cyclic polarization alone. In addition, a fretting control group in which no cyclic polarization was conducted was used to assess the effect of micromotion without cyclic polarization. The results of this study showed that fretting corrosion damage can be achieved on Ti6Al4V and SS316L washer crevices when subjected to micromotion alone. The test method did not induce more corrosion on Ti6Al4V samples when crevices were tested with cyclic polarization alone. Furthermore, the results found that cyclic polarization in combination with micromotion did not achieve the same fretting corrosion damage on the CoCrMo samples as observed in explants. Still, electrochemical test methods have potential for accelerating corrosion damage within crevices when combined with existing fretting corrosion testing and therefore could potentially reduce test durations for fretting corrosion susceptibility evaluations for medical devices having modular taper connections.