bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis Characterization and In silico Anticancer Activity of D-ring Substituted Steroidal Pyrazolecarboxamides
Authors: Abilasha D. , Jeysiha C. , Palanisamy P. , Kumaresan S. 
Published: July 2023

In the present study, a few D ring substituted pyrazolecarboxamide derivatives were synthesized from the key intermediate 2,3-dihydrothiopyrano[3,2-c]thiochromen-4(5H)-one(2). In order to determine the structure-activity relationships, the pyrazolecarboxamide derivatives (7 a-m) were analyzed for anticancer activity and molecular docking studies were carried out against two cancer cell lines (HeLa and HCT116). The structures of all these compounds have treating been elucidated on the basis of their spectral data. We performed docking studies with the selective inhibitor proteins 4J96 (HeLa) and 5FGK (HCT 116). The binding energy of compound 7k (-9.6 Kcal/mol-HeLa and -10.1 Kcal/mol-HCT116) was found to be lower than that of all other pyrazole derivatives as well as standard doxorubicin. Furthermore, compound 7k was also found to be a promising anticancer agent against 4J96 and 5FGK cells, given its significant inhibitory effect [IC50=20.56μM (HeLa) and 18.19μM (HCT116)] compared to doxorubicin [IC50=21.32 μM (HeLa) and 19.58 μM (HCT116)]. Hence it is understood that, the pyrazole carboxamide derivatives (7k) has selectivity for inhibitor proteins having anticancer activity against HeLa and HCT116 compared with doxorubicin.
Vision par ordinateur pour la reconnaissance des gestes musicaux des doigts
Authors: Manitsaris Sotiris 
Published: July 2023

La vision par ordinateur est la seule technologie permettant la reconnaissance des gestes musicaux des doigts, sans interférence entre le musicien et son instrument, et à un faible coût. Le système PianOrasis propose deux approches pour la reconnaissance : a) la reconnaissance statique, ou reconnaissance des doigtés, et b) la reconnaissance dynamique. La reconnaissance statique s’applique à chaque image de la vidéo, en comparant les caractéristiques de l’image avec le modèle déterministe du geste. La reconnaissance dynamique présuppose la modélisation stochastique du geste et elle s’applique à un ensemble de séquences d’images.
Musique électronique « live » et « recasting » :Trois cas d’étude
Authors: de Sousa Dias António 
Published: July 2023

Ce texte porte une discussion autour d’un de nos axes de recherche : la récupération en vue de l’électronique “live”. Nous présentons trois cas d’étude : Jorge Peixinho, Harmónicos (1967), Jorge Peixinho, Sax-Blue (1982) et Cândido Lima, Ñcáãncôa (1995). Nous discuterons le besoin de la redistribution (Recasting) et la raison du choix de cette désignation. Puis, à propos des problèmes apportés dans chaque cas, nous présentons les solutions trouvées.
La poétique du « live » en musique électroacoustique
Authors: Emmerson Simon 
Published: July 2023

Dans cet article, le compositeur-chercheur Simon Emmerson évoque la question du direct en musique électronique et mixte, avant d’aborder sa poétique de la musique électronique live, vivante et basée sur une « écoute écologique ». Emmerson s’appuie sur certaines de ses productions musicales majeures, telles que Spirit of '76, Sentences, Points of continuation, Frictions et Resonances. Il évoque au passage le problème de la pérennité des œuvres avec dispositif électronique contrainte par le passage de l’analogique au numérique et du matériel au logiciel.
Study Of Macular Function and Morphology After Transepithelial Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus
Authors: Tawfeek Mohammed Mohammed Mahdy , Tohamy Dalia Mohamed Aly , Ahmed Hanan Mohamed Abdel Hamid , Rady Ahmed M. Nashaat Ali 
Published: July 2023

Objective The aim of this work is to evaluate the effect of transepithelial accelerated cross-linking (Epi-on CXL) on the macular function and morphology in progressive keratoconus. Patients and Methods The study included 25 patients with progressive keratoconus with age ranged between 18 and 32 years. Epi-On Accelerated CXL was done for all cases. Evaluation was performed 2 and 6 weeks postoperatively after transepithelial (Epi-on) accelerated CXL by Optical coherence tomography (OCT) and multifocal electroretinography (mf-ERG). Results The central foveal thickness (CFT) decreased from 165.1 ± 21.5 µm to 163.4 ± 24.2 µm 2 weeks postoperatively to 164.8 ± 23.9 µm 6 weeks postoperatively, with no statistically significant difference. The preoperative retinal response density (RRD) decreased in macular ring 1 (foveal area of 2.8 degrees) from 179.5 ± 52.1 nV/deg2 preoperatively to 134.7 ± 43.2 nV/deg2 and 146.7 ± 41.6 nV/deg2 in 2 and 6 weeks, respectively postoperatively with statistically significant difference (p = 0.012), while the other 4 rings showed statistically insignificant difference (p >0.05) .On the other hand, implicit time latency (Pl) showed statistically insignificant difference between preoperative and postoperative values (p >0.05) in all macular rings. Conclusion There is a minimal change in macular morphology after Epi-on accelerated CXL in progressive keratoconus, however, no significant change in macular function without any structural changes in progressive keratoconus 6 weeks postoperatively. A longer follow-up period studies are recommended to provide more information.
The influence of yeast format and pitching rate on Scotch malt whisky fermentation kinetics and congeners
Authors: Reid Struan , Speers Alex , Lumsden William , Willoughby Nicholas , Maskell Dawn 
Published: July 2023

Yeast format and pitching rate are variables which can be easily manipulated in a distillery environment but are seldom altered. Fermentations using dried and liquid yeast were studied at laboratory scale and compared by application of a 4-parameter logistic model to measurements of the decline in apparent extract during fermentation. Congener analysis of new make distillate allowed comparison between compounds of interest produced during fermentation. The liquid yeast format demonstrated a significant reduction (p<0.05) in lag time, which was 68% shorter than dried yeast. Despite this, longer overall fermentation times were observed due to a slower exponential phase as compared to the dried yeast format. Alteration of the yeast pitching rate using dried and liquid formats, demonstrated that high rates resulted in reduced lag times. The maximum fermentation rates (Vmax) were assessed from the fermentation models and no consistent trend could be identified. Dried yeast was observed to achieve its maximum fermentation rate when underpitched. Substantially higher Vmax ­values were obtained with overpitched liquid yeast fermentations, resulting in faster fermentations, compared to underpitched liquid yeast fermentations. The liquid yeast format created more esters compared to dried yeast. The concentration of ethyl esters generally trended downwards for fermentations pitched with less yeast which fully attenuated. By combining the results of these studies, distillers can make informed decisions to optimise spirit character, quality, and distillery production.
Pembentukan Sikap Toleransi Siswa Melalui Pembelajaran Pendidikan Agama Islam (PAI) Berbasis Multikultural di SMAN 2 Mataram
Authors: Aryanti Dwiyani  , Eva Sofia Sari  
Published: July 2023

In this paper, the problem studied is the formation of student tolerance through multicultural-based Islamic Religious Education (PAI) learning in public schools. This study puts forward religious values, namely tolerance. The importance of multicultural-based Islamic Religious Education (PAI) not only instills religious values ​​in students, but also fosters an attitude of tolerance and inclusiveness (openness) in progress. In addition, there is still a lack of understanding of tolerance, difference, diversity, and progress in the lives of students, which causes the occurrence of multicultural values ​​in schools to be lost and not properly actualized. The flow of modernization and globalization is also one part that affects the multicultural crisis in students. An attitude of tolerance, respect and respect for every difference is the basic capital for students in responding to and understanding every difference in life, because this is very much in line with the values ​​of Islamic teachings, namely respecting every difference between fellow humans. Thus the tolerant attitude taught in learning Islamic religious education can provide an understanding of the meaning and meaning of each progression so that students avoid exclusivity (closed), consider themselves the most right and think others are wrong. The research method used is qualitative research with data collection techniques using observation, interviews and documentation and is supported by various relevant references. This paper provides an alternative, namely "How to form student tolerance through multicultural-based Islamic Religious Education (PAI) learning in schools both in conceptual and practical settings" so that students have an inclusive attitude in accepting any differences, diversity or advancement
Psikologi Pendidikan Dan Strategi Membentuk Kepribadian Islami Perspektif Al-Qur’an
Authors: Abdul Malik  , Fitrah Sugiarto  
Published: July 2023

Nowadays, the issue of national personality that is fading away and far from being noble is echoing again, this is triggered by various incidents in Indonesian society. Personality seems to be experiencing complex and complicated problems. So the contribution of Islamic Education which is a field of science that studies humans with various aspects is required to be present in this realm. Why is that because Islam is the religion of Allah which was revealed to the Apostles as Allah's guidance and grace for mankind, which guarantees the welfare of his material and spiritual, worldly and spiritual life. Islamic education is in trouble. The acceptance of the dichotonomic principle between the religious sciences and the general sciences is an indication of the fragility of the philosophical basis of Islamic education. This dichotonomy is clearly seen in the dualism of the education system in Muslim countries, including Indonesia. In fact, Islamic education wants education to be able to stimulate humans to think independently in order to face a good and happy life. This is the essential meaning of the prophet Muhammad SAW's prophetic mission, namely to educate humans, lead to the path of Allah SWT, and teach to uphold a healthy, prosperous, material, spiritual, just, and harmonious society.
Prophet Muhammad SAW was sent to develop the quality of human life, purify morals and equip him with the provisions needed to face life in this world and the hereafter. The greatest mission of the Prophet Muhammad SAW was to perfect human morals, which basically means that humans have a healthy soul and personality, Al-Qur'an mentions the Prophet Muhammad SAW as the best example in this regard. So to achieve this direction requires a good and simultaneous strategy
Upaya Guru PAI dalam Meningkatkan Motivasi Belajar Siswa di Sma Hidayatus Salam Lowayu Dukun Gresik
Authors: Kusuma Ningtias Ratih , Mahbubah Zaimatul 
Published: July 2023

The Purposes of this study were to: (1) Describe the efforts of PAI teachers in increasing students’ learning motivation at SMA Hidayatus Salam Lowayu Dukun Gresik. (2) Describe the obstacles experienced by PAI teachers in increasing students’ learning motivation at SMA Hidayatus Salam Lowayu Dukun Gresik. (3). Describe the solutions that PAI teachers do in increasing students’ learning motivation at SMA Hidayatus Salam Lowayu Dukun Gresik.
The research used a qualitative research as approach as approach and case study as research design. The data collection used observation, interview, and documentation techniques: The data analysis used following steps reduction, display and draw conclusions.
The results of this study indicate that: (1) The forms of PAI teachers' efforts in increasing students' learning motivation at Hidayatus Salam Lowayu Dukun Gresik High School such as: giving grades from student learning outcomes, giving praise and prizes, giving tests and assignments, using learning methods that varied in teaching, using learning media and giving punishment. (2) Obstacles faced by PAI teachers in increasing student motivation at Hidayatus Salam Lowayu Dukun Gresik High School are as follows: when teachers use learning methods to increase learning motivation, some students are a bit slow in the learning process. Meanwhile, when teachers use learning media to increase learning motivation, students have different grasping powers, students who have less understanding will find it difficult to understand the material taught by the teacher. And the obstacle faced by the teacher itself is the use of learning methods and media in the material being taught. Meanwhile (3) the solution that the PAI teacher does in overcoming these obstacles or problems is to provide opportunities for children to consult with the teacher regarding the obstacles he is experiencing, use various learning methods and learning media, maintain interest, willingness and enthusiasm for learning in students, create an attractive learning environment, provide learning agreements or contracts, provide punishments that build students up.
Penerapan Model Pembelajaran TPS Dengan Aplikasi Handphone Untuk Meningkatkan Hasil Belajar Informatika Siswa Kelas X Akomodasi Perhotelan 2 SMK Negeri 24 Jakarta
Authors: Astoeti Tjandra Sarie 
Published: July 2023

Menggunakan alat peraga handphon/aplikasi pada mata pelajaran Informatika dapat meningkatkan hasil belajar Siswa Kelas X Perhotelan 2 SMK Negeri 24 Jakarta. Tujuan penelitian ini adalah 1) Untuk mengetahui bagaimana Penerapan Model Pembelajaran TPS (Think,Pair,Share) pada mata pelajaran Informatika materi pokok Analisis Data dengan menggunakan alat peraga Handphone/Aplikasi, 2) Untuk meningkatkan hasil belajar siswa kelas X Perhotelan 2 SMK Negeri 24 Jakarta pada mata pelajaran Informatika materi pokok bab 5 (Analisis Data) setelah diterapkan model pembelajaran TPS (Think, Pair, Share) menggunakan alat peraga Handphone/Aplikasi. Subyek penelitian ini adalah siswa kelas X Perhotelan 2 yang berjumlah 36 siswa, terdiri atas: 8 laki-laki dan 27 perempuan. Prosedur penelitian tindakan kelas ini ditempuh dalam 2 siklus. Hasil penelitian menunjukkan bahwa: terjadinya peningkatan hasil belajar siswa kelas X Perhotelan 2 melalui penerapan model pembelajaran TPS (Think,Pair,Share). Hasil belajar siswa pada tes akhir siklus I memiliki nilai rata-rata sebesar 55,37 dengan siswa yang dinyatakan tuntas mencapai 7 siswa (17,07%). Sedangkan nilai rata-rata kelas meningkat pada siklus II menjadi 82,93 dan sebanyak 34 siswa (82,93%) dinyatakan tuntas baik secara individual maupun klasikal. Perhatian dan antausiasme siswa meningkat, kegiatan diskusi kelompok pun sudah terlihat efektif karena siswa-siswi aktif dalam kerja kelompok serta siswa sudah bisa mengemukakan pendapatnya masing masing.
CÂNCER DE MAMA: A IMPORTÂNCIA DO DIAGNÓSTICO PRECOCE PARA O CONTROLE DE DOENÇA
Authors: do Nascimento Gabrielle Rocha , dos Reis Thais Nobres , Fonseca Fernando Luiz Affonso , de Abreu Luciane Morelis , Araújo Erica Chagas , Raimundo Juliana Zangirolami , Veiga Glaucia Luciano 
Published: July 2023

OBJETIVO: A presente revisão tem como objetivo fazer um levantamento bibliográfico dos achados mais recentes sobre o CM e apresentar os principais métodos diagnósticos, que contribuem para o diagnóstico precoce da doença, assim como os principais tratamentos propostos. MÉTODO: Revisão integrativa que levantará os principais artigos científicos sobre o CM, assim como, as informações oficiais de sites governamentais sobre o tema, os principais dados epidemiológicos dos últimos doze anos e os métodos diagnósticos. RESULTADO: Foram selecionados para leitura 148 (cento e quarenta e oito) conteúdos que possuíam o critério de inclusão, após nova análise foram descartados 88 (oitenta e oito) no processo de construção do texto, resultando em uma base teórica de 60 (sessenta) conteúdos divididos em 27 (vinte sete) particularidades. CONCLUSÃO: O CM é uma patologia que tem elevado índice de morbidade e mutilação, além de seu grande percentual de impacto, tendo em vista a importância do diagnóstico precoce de CM se faz necessário a implantação de estratégias de conscientização e sugere-se que os métodos recentes de diagnóstico sejam inseridos no Sistema Público de Saúde brasileiro.
Palavras-chave: Câncer de mama, diagnóstico precoce, rastreamento, exames
Ultramodernidad como estilo de pensamiento en el proceso de aprendizaje en Emprendimiento y Gestión
Authors: Medina-Gorozabel Glenda , Giler-Medina Patricio 
Published: July 2023

La adquisición y asimilación de competencias educacionales presenta desafíos en el proceso de aprendizaje, respecto a una educación ética, compartida, autónoma, racional y compleja en la sociedad del conocimiento y del aprendizaje. El presente ensayo tuvo por objetivo interpretar el rol de la Ultramodernidad como estilo de pensamiento en el proceso de aprendizaje en Emprendimiento y Gestión. Se empleó el enfoque cualitativo de investigación, con el apoyo en la investigación básica, exploratoria y documental. A nivel teórico, se aplicaron los métodos analítico, sintético y deductivo. Se utilizó fuentes documentales en bases de datos científicas como técnica de investigación directa. Finalmente, se estableció que la práctica educativa en Emprendimiento y Gestión necesita de un nuevo enfoque pedagógico que se alinea y corresponde al Ultramodernismo como estilo de pensamiento.

Translator

La adquisición y asimilación de competencias educacionales presenta desafíos en el proceso de aprendizaje, respecto a una educación ética, compartida, autónoma, racional y compleja en la sociedad del conocimiento y del aprendizaje. El presente ensayo tuvo por objetivo interpretar el rol de la Ultramodernidad como estilo de pensamiento en el proceso de aprendizaje en Emprendimiento y Gestión. Se empleó el enfoque cualitativo de investigación, con el apoyo en la investigación básica, exploratoria y documental. A nivel teórico, se aplicaron los métodos analítico, sintético y deductivo. Se utilizó fuentes documentales en bases de datos científicas como técnica de investigación directa. Finalmente, se estableció que la práctica educativa en Emprendimiento y Gestión necesita de un nuevo enfoque pedagógico que se alinea y corresponde al Ultramodernismo como estilo de pensamiento.
Alteration of the oral and gut microbiota in patients with Kawasaki disease
Authors: Zeng Qinghuang , Zeng Renhe , Ye Jianbin 
Published: July 2023

Background
Kawasaki disease (KD) is a multi-systemic vasculitis that primarily affects children and has an unknown cause. Although an increasing number of studies linking the gut microbiota with KD, the unchallengeable etiology of KD is not available.

Methods
Here, we obtained fecal and oral samples from KD patients and healthy controls, and then we use high-throughput sequencing to examine the diversity and composition of microbiota.

Results
Results showed that both in the gut and oral microbiota, the diversity of KD patients was significantly lower than that of the healthy controls. In the gut microbiota, a higher abundance of Enterococcus (40.12% vs less than 0.1%), Bifidobacterium (20.71% vs 3.06%), Escherichia-Shigella (17.56% vs 0.61%), Streptococcus (5.97% vs 0.11%) and Blautia (4.69% vs 0.1%) was observed in the KD patients, and enrichment of Enterococcus in the patients was observed. In terms of oral microbiota, the prevalence of Streptococcus (21.99% vs 0.1%), Rothia (3.02% vs 0.1%), and Escherichia-Shigella (0.68% vs 0.0%) were significantly higher in the KD patients, with the enrichment of Streptococcus and Escherichia-Shigella. Additionally, significant differences in microbial community function between KD patients and healthy controls in the fecal samples were also observed, which will affect the colonization and reproduction of gut microbiota.

Conclusions
These results suggested that the dysbiosis of gut and oral microbiota are both related to KD pathogenesis, of which, the prevalence of Enterococcus in the gut and higher abundance of Streptococcus and Escherichia-Shigella in the oral cavity will be a potential biomarker of the KD. Overall, this study not only confirms that the disturbance of gut microbiota is a causative trigger of KD but also provides new insight into the oral microbiota involved in KD pathogenesis.
Effect of Dried Mushroom Supplementation on Muscles Composition, Nutrient Utilization and Economics in Broiler Chicken
Authors: Kumar Kailash , Kumar Satendra , Kumar Veerendra , Prakash Ved , Tripathi Sanjay Kumar , Katiyar Shiv Shanker , Saikanth D. R. K. 
Published: July 2023

The experiment was conducted at poultry farm of Chandra Shekar Azad University, Kanpur during summer season of date.. to assess the muscles composition, nutrient utilization and economics on feeding dried mushroom to broiler chickens. Broiler chicken supplemented with the edible P. florida mushroom, 20g/kg of dried P. eoes mushroom, and 20g/kg of dried P. sajor caju mushroom. Day-old broiler chicks from a single hatch were weighed individually and divided into 4 groups of six birds each at random. The birds were given a basic diet for starter and finisher rations for 0–3 and 4-6 weeks, respectively. One group (G1) was kept as the control, while the remaining three groups (G2, G3, and G4) given their chicks the same basic food as G1 combined with various types of mushrooms. Groups G2, G3, and G4 were fed 20g/kg of dry P. florida mushroom, 20g/kg of dried P. eoes mushroom, and 20g/kg of dried P. sajor caju mushroom. Throughout the six-week testing period, food and drink were freely available. Feed consumption, Muscles composition and nutrient utilization values were monitored weekly. Economics was also calculated. It was found that, muscles composition highest in G3 whereas nutrient utilization and benefit cost ratio highest in G2. The application of Pleurotuus sp.mushroom (P. florida, P.eoes, and P.sajor caju respectively) in different groups in the diet of broiler chicks improved the growth rate in summer season. The Pleurotous florida mushroom is therefore required for an improvement in growth performance during the summer.