bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leading basic modes of spontaneous activity drive individual functional connectivity organization in the resting human brain
Authors: Chen Xi , Ren Haoda , Tang Zhonghua , Zhou Ke , Zhou Liqin , Zuo Zhentao , Cui Xiaohua , Chen Xiaosong , Liu Zonghua , He Yong , Liao Xuhong 
Published: August 2023

AbstractSpontaneous activity of the human brain provides a window to explore intrinsic principles of functional organization. However, most studies have focused on interregional functional connectivity. The principles underlying rich repertoires of instantaneous activity remain largely unknown. We apply a recently proposed eigen-microstate analysis to three resting-state functional MRI datasets to identify basic modes that represent fundamental activity patterns that coexist over time. We identify five leading basic modes that dominate activity fluctuations. Each mode exhibits a distinct functional system-dependent coactivation pattern and corresponds to specific cognitive profiles. In particular, the spatial pattern of the first leading basis mode shows the separation of activity between the default-mode and primary and attention regions. Based on theoretical modelling, we further reconstruct individual functional connectivity as the weighted superposition of coactivation patterns corresponding to these leading basic modes. Moreover, these leading basic modes capture sleep deprivation-induced changes in brain activity and interregional connectivity, primarily involving the default-mode and task-positive regions. Our findings reveal a dominant set of basic modes of spontaneous activity that reflect multiplexed interregional coordination and drive conventional functional connectivity, furthering the understanding of the functional significance of spontaneous brain activity.
Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation
Authors: de Jonckheere Bianca , Kollotzek Ferdinand , Münzer Patrick , Göb Vanessa , Fischer Melina , Mott Kristina , Coman Cristina , Troppmair Nina Nicole , Manke Mailin-Christin , Zdanyte Monika , Harm Tobias , Sigle Manuel , Kopczynski Dominik , Bileck Andrea , Gerner Christopher , Hoffmann Nils , Heinzmann David , Assinger Alice , Gawaz Meinrad , Stegner David , Schulze Harald , Borst Oliver , Ahrends Robert 
Published: August 2023

AbstractDuring megakaryopoiesis, megakaryocytes (MKs) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here, we adopt a lipid-centric multiomics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation. Data reveal that MK differentiation is driven by an increased fatty acyl import and de novo lipid synthesis, resulting in an anionic membrane phenotype. Pharmacological perturbation of fatty acid import and phospholipid synthesis blocked membrane remodeling and directly reduced MK polyploidization and proplatelet formation, resulting in thrombocytopenia. The anionic lipid shift during megakaryopoiesis was paralleled by lipid-dependent relocalization of the scaffold protein CKIP-1 and recruitment of the kinase CK2α to the plasma membrane, which seems to be essential for sufficient platelet biogenesis. Overall, this study provides a framework to understand how the MK lipidome is altered during maturation and the effect of MK membrane lipid remodeling on MK kinase signaling involved in thrombopoiesis.
Economic evaluation of 27,540 patients with mood and anxiety disorders and the importance of waiting time and clinical effectiveness in mental healthcare
Authors: Catarino Ana , Harper Samuel , Malcolm Robert , Stainthorpe Angela , Warren Graham , Margoum Morad , Hooper Joel , Blackwell Andrew D. , Welchman Andrew E. 
Published: August 2023

AbstractUnderstanding the drivers of health and economic cost for the treatment of mental health conditions is critical to meet the accelerating demands for care. We conducted an economic evaluation of real-world healthcare-systems data from 27,540 patients receiving care for a mood or an anxiety disorder within the UK National Healthcare Service. Using Markov models built on discrete health states to compare the cost-effectiveness of different interventions, we show that the principal drivers of healthcare cost relate to waiting times and treatment effectiveness. We find that internet-delivered cognitive behavioral therapy has a ‘dominant’ incremental cost-effectiveness ratio relative to standard care, offering similar clinical effectiveness but with shorter treatment times. In most healthcare systems, the clinical effectiveness of mental healthcare remains unquantified, and long treatment times are common. The potential for these findings to inform mental healthcare policy is substantial, particularly around immediacy of access and the importance of outcomes-focused quality management.
Cheminformatics and Bioinformatics at the Interface with Systems Biology
Authors: Kaushik Aman Chandra , Mehmood Aamir , Wei Dongqing , Nawab Sadia , Sahi Shakti , Kumar Ajay 
Published: August 2023

The cost of drug development is increasing, and investment returns are decreasing. The number of drugs approved by FDA is in decline in terms of the number of new molecular entities (NMEs). Amongst the reasons noted for this are the adverse side effects and reduced efficiency of many of the potential compounds. This is a problem both for the pharmaceutical industry and for those suffering from diseases for which there are no or few available treatments.
Advances in computational chemistry, computer science, structural biology and molecular biology have all contributed to improved drug design strategies and reduced the time taken for drug discovery. By interfacing cheminformatics and bioinformatics with systems biology we can create a powerful tool for understanding the mechanisms of patho-physiological systems and identifying lead molecules for various diseases. This integration of drug design approaches can also play a crucial role in the prediction and rationalization of drug effects and side effects, improving safety and efficacy and leading to better approval rates.
Addressing the lack of knowledge on the fundamental aspects of the various computational tools for drug discovery, this book is a compilation of recent bioinformatics and cheminformatics approaches, and their integration with systems biology. Written primarily for researchers and academics in chem- and bioinformatics, it may also be a useful resource for advanced-level students.
Physical Activity in Children With Hearing Loss: A Systematic Review
Authors: Nedrud Cassandra , Schafer Erin C. 
Published: August 2023

Purpose:
This systematic review follows the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and aims to examine physical activity in children with hearing loss. Research questions aimed to compare physical activity levels and participation in organized sports in children with hearing loss relative to peers with no hearing loss. A second aim was to examine the impact of the degree of hearing loss and identify modifiable barriers to physical activity.

Method:

Three databases were utilized to identify relevant studies: PubMed, Human Kinetics, and Science Direct. All peer-reviewed studies included in the systematic review focused on physical activity of children with hearing loss ages 0–18 years and were published in English in 2010 or later. Data extraction and verification of the extracted data were completed by the first author, and the data were discussed between authors. Nine peer-reviewed studies with varying research designs and sample sizes were included in the systematic review. Each study was assessed using the adapted McMaster Critical Review Form-Quantitative Studies to establish the quality level; ratings across studies were good (
n
= 1) or excellent (
n
= 7).

Results:
Results of the systematic review suggest that children with hearing loss have substantially lower physical activity and participation in organized sports due to the influence of social inclusion and support, parent-related issues, gender, and the presence of other disabilities.

Conclusions:
All research questions were addressed in some capacity. Given that physical activity is vital to the health and development of children, the results of this study support the need for future research focused on mitigation of these and other barriers.
A Roadmap to Enhance Care for People Living With Primary Progressive Aphasia: What Can Be Done Now?
Authors: Gallée Jeanne 
Published: August 2023

Purpose:
People living with primary progressive aphasia (PwPPA) face a progressive decline in speech, language, and communication capabilities. PwPPA live with relatively well-preserved cognition, which further contributes to their insight and grief resulting from the losses of language and independence, as well as the misconceptions surrounding the condition. This clinical focus article underscores the clinical necessity of enhancing access to and the quality of care provided to PwPPA while highlighting the unique role of the speech-language pathologist in these services. To help accomplish this, evidence-based practice informed by the current literature is offered to speech-language pathologists working with this target population.

Conclusions:
Palliative, person-centered services for the assessment and management of PPA are necessary to shape the most optimal care trajectory of PwPPA and their care partners. Speech-language pathologists can take concrete steps to improve the assessment and intervention experiences for their clients living with this condition. These steps should include (a) clearly defining the speech-language pathologist's role, (b) providing person-centered processes of assessment, management, and care, (c) defining the provider team, (d) advocating for the client across health care professions, (e) and knowing when to refer out to additional services.
Machine learning and human‐machine trust in healthcare: A systematic survey
Authors: Lin Han , Han Jiatong , Wu Pingping , Wang Jiangyan , Tu Juan , Tang Hao , Zhu Liuning 
Published: August 2023

AbstractAs human‐machine interaction (HMI) in healthcare continues to evolve, the issue of trust in HMI in healthcare has been raised and explored. It is critical for the development and safety of healthcare that humans have proper trust in medical machines. Intelligent machines that have applied machine learning (ML) technologies continue to penetrate deeper into the medical environment, which also places higher demands on intelligent healthcare. In order to make machines play a role in HMI in healthcare more effectively and make human‐machine cooperation more harmonious, the authors need to build good human‐machine trust (HMT) in healthcare. This article provides a systematic overview of the prominent research on ML and HMT in healthcare. In addition, this study explores and analyses ML and three important factors that influence HMT in healthcare, and then proposes a HMT model in healthcare. Finally, general trends are summarised and issues to consider addressing in future research on HMT in healthcare are identified.
A data‐driven distributed fault diagnosis scheme for large‐scale systems based on correlation analysis
Authors: Li Zhennan , Li Linlin , Ding Steven X. 
Published: August 2023

AbstractThis paper studies data‐driven distributed fault diagnosis for large‐scale systems using sensor networks. To be specific, a distributed fault detection scheme based on correlation analysis is first proposed to improve the fault detection performance by minimizing the impact of noise‐induced uncertainty. The core of the method is to implement the correlation of the coupled nodes to reduce the covariance of the residual signal in a distributed manner. Then, a fault localization approach is developed to locate the fault by measuring and comparing the degree of abnormality. A case study on Tennessee Eastman process is given in the end to demonstrate the proposed approach.
A Fully Digital Auricular Splint Workflow for Post-Keloid Excision
Authors: Maria Rahmat , Kok Yee Onn , Teoh Khim Hean 
Published: August 2023

AbstractEar keloids are challenging lesions to treat due to high recurrence rates postexcision. Conservative compression techniques as adjunct treatment have been reported to be effective. An innovative technique of using computer-aided design/computed-aided manufacturing to print a customized auricular splint improves efficiency and comfort level for patients compared with conventional methods. The ear is scanned using an intraoral scanning 2 weeks postsurgery. A two-piece auricular splint is designed on the digital model, incorporating perforated projections for three nylon screws for retention of the splint. The splint is printed with clear acrylic material, postprocessed, and finished. The patient is taught to assemble the components of the splint and instructed to wear for at least 8 hours daily. The surgery site reviewed for any ulceration, pain, or recurrence of keloid for 6 months. During the 6-month review, the excision scar remained flat and pink. The patient also reports unrestricted daily activities. The digital workflow increases comfort for the patient and reduces the number of hours required to produce a customized auricular splint compared with conventional methods. A fully digital workflow for a printed auricular splint should be considered for adjunctive treatment to excision of ear keloids.
High-Fidelity Perforator Visualization for Cadaver Dissection in Surgical Training
Authors: Wong Allen Wei Jiat , Kok Yee Onn , Chew Khong Yik , Tan Bien Keem 
Published: August 2023

AbstractIn the first half of the third century B.C., Herophilus and Erasistratus performed the first systematic dissection of the human body. For subsequent centuries, these cadaveric dissections were key to the advancement of anatomical knowledge and surgical techniques. To this day, despite various instructional methods, cadaver dissection remained the best way for surgical training. To improve the quality of education and research through cadaveric dissection, our institution has developed a unique method of perforator-preserving cadaver injection, allowing us to achieve high-fidelity perforator visualization for dissection studies, at low cost and high efficacy. Ten full body cadavers were sectioned through the base of neck, bilateral shoulder, and hip joints. The key was to dissect multiple perfusing arteries and draining veins for each section, to increase “capture” of vascular territories. The vessels were carefully flushed, insufflated, and then filled with latex dye. Our injection dye comprised of liquid latex, formalin, and acrylic paint in the ratio of 1:2:1. Different endpoints were used to assess adequacy of injection, such as reconstitution of eyeball volume, skin turgor, visible dye in subcutaneous veins, and seepage of dye through stab incisions in digital pulps. Dissections demonstrated the effectiveness of the dye, outlining even the small osseous perforators of the medial femoral condyle flap and subconjunctival plexuses. Our technique emphasized atraumatic preparation, recreation of luminal space through insufflation, and finally careful injection of latex dye with adequate curing. This has allowed high-fidelity perforator visualization for dissection studies.
Spontaneous Vertebral Artery Arteriovenous Fistula with Neurofibromatosis Type I and Its Management with Covered Stent
Authors: Diyora Batuk , Purandare Anup , Devani Kavin , Palave Prakash 
Published: August 2023

AbstractVertebro-vertebral fistulas (VVFs) are uncommon vascular pathology. It can be either primary (spontaneous) or secondary (iatrogenic or mechanical trauma). Spontaneous vertebral arteriovenous malformation is often associated with connective tissue disorders. Cases associated with neurofibromatosis type I (NF I) are even rarer. Management of VVF with covered stent is an emerging option for construction of vertebral artery. It not only preserves the flow of the parent artery but also has immediate exclusion of the fistula from the parent artery. A 30-year-old pregnant female patient presented with cervical bruit and left upper limb radiculopathy. She was a known case of NF I. Magnetic resonance imaging cervical spine revealed multiple flow voids compressing the cervical spinal cord and nerve roots. Digital subtraction angiography revealed a vertebral artery arteriovenous fistula. She underwent endovascular treatment in the form of a covered stent. Her clinical symptoms immediately improved. She was asymptomatic at the 1-year follow-up.
Invasive Streptococcus pyogenes: A Short Literature Review
Authors: Tanrıverdi Çaycı Yeliz , Altındiş Mustafa 
Published: August 2023

Abstract
Objective Streptococcus pyogenes also called Group A streptococci (GAS) is an important pathogen known since past years and infects millions of people around the world every year and can cause death. Although it often causes pharyngitis and skin infections, it can also spread to the bloodstream and cause invasive GAS (iGAS) infections. In this review, studies on the epidemiology of GAS and iGAS and vaccine studies were reviewed.
Methods A comprehensive search of databases was conducted up to April 1, 2023 to related studies, in English using the following terms: S. pyogenes, GAS, invasive S. pyogenes infections, iGAS, S. pyogenes vaccine. The data extraction was conducted by two investigators using the same methodology.
Results There has been an increase in iGAS infections in various countries in the last year and they have been followed closely. Although the reason for the increase in iGAS cases cannot be determined exactly, it is thought that the recent removal of coronavirus disease 2019 restrictions and the increase in the number of individuals susceptible to GAS and to viral respiratory pathogens is thought to have caused this situation. Another important issue with GAS is the vaccine studies. Vaccines are based on two different targets: M protein-based and non-M protein-based. Phase-I clinical trials have been initiated for some vaccines.
Conclusion The increase in recent iGAS infections will draw attention to this agent and accelerate vaccine studies.
Prognostic Factors of Mortality and Functional Outcome for Acute Subdural Hematoma: A Review Article
Authors: Beucler Nathan 
Published: August 2023

AbstractAcute subdural hematoma (ASDH) is the most frequent intracranial traumatic lesion requiring surgery in high-income countries. To date, uncertainty remains regarding the odds of mortality or functional outcome of patients with ASDH, regardless of whether they are operated on. This review aims to shed light on the clinical and radiologic factors associated with ASDH outcome. A scoping review was conducted on Medline database from inception to 2023. This review yielded 41 patient series. In the general population, specific clinical (admission Glasgow Coma Scale [GCS], abnormal pupil exam, time to surgery, decompressive craniectomy, raised postoperative intracranial pressure) and radiologic (ASDH thickness, midline shift, thickness/midline shift ratio, uncal herniation, and brain density difference) factors were associated with mortality (grade III). Other clinical (admission GCS, decompressive craniectomy) and radiologic (ASDH volume, thickness/midline shift ratio, uncal herniation, loss of basal cisterns, petechiae, and brain density difference) factors were associated with functional outcome (grade III). In the elderly, only postoperative GCS and midline shift on brain computed tomography were associated with mortality (grade III). Comorbidities, abnormal pupil examination, postoperative GCS, intensive care unit hospitalization, and midline shift were associated with functional outcome (grade III). Based on these factors, the SHE (Subdural Hematoma in the Elderly) and the RASH (Richmond Acute Subdural Hematoma) scores could be used in daily clinical practice. This review has underlined a few supplementary factors of prognostic interest in patients with ASDH, and highlighted two predictive scores that could be used in clinical practice to guide and assist clinicians in surgical indication.
Primary Retroperitoneal Masses: A Pictorial Essay
Authors: Gupta Abhishek , Manchanda Alpana , Singh Sapna , Singh Rajdeep , Khurana Nita , Durgad Aishwarya S. 
Published: August 2023

AbstractPrimary retroperitoneal masses include a diverse and uncommon group of lesions that arise within the retroperitoneal space, but do not originate from any retroperitoneal organs. The majority of the lesions are malignant and imaging plays a pivotal role in the detection, staging, and preoperative planning. The evaluation of primary retroperitoneal masses is often challenging owing to the unfamiliarity with the common imaging features of various diseases affecting it. This article describes the multidetector computed tomography appearance of some primary retroperitoneal masses.
Love me, love my dog: Cohabitation, dogs and romantic relationships among college students
Authors: Tallichet Suzanne E. , Perkins Elizabeth B. , Chang I. Joyce , Long-Mills Em , Knox David 
Published: August 2023

Abstract
This research focused on the impact of having one or more dogs on romantic relationships among college-age cohabiting couples. One hundred and eighteen romantic cohabitants, among whom either or both partners had a dog, from three universities completed an anonymous, voluntary 41-item survey. Quantitative data included the bulk of the items analyzed using Version 25 of the IBM Statistical Package for Social Sciences (SPSS) program. Qualitative data were generated using three open-ended questions and analyzed using a thematic analysis approach. Over three-fourths (77%) of the respondents reported a positive effect, 17% reported a neutral impact, and 6% reported a negative outcome. The positive effects included “companionship” (97%), “relationship enhancer” (88%), and “like having a child together” (76%). Negative outcomes included jealousy, less time spent together, and stress. Men were significantly more likely to report that their partner was jealous of the dog, while women were significantly more likely to talk to their dogs about problems. Whites, more than racial-ethnic minorities, typically reported a more positive than negative effect of dogs on their romantic relationships. The study emphasizes the positive impact of a dog(s) on the romantic relationship of cohabiting couples and reveals some of the negative impacts of living with one or more dogs on young cohabitating couples’ relationships. The findings provide relatively new insights into the influence of gender and race-ethnicity on dogs and cohabiting couples and suggest areas for further research.
Investigating the effect of circuit cutting in QAOA for the MaxCut problem on NISQ devices
Authors: Bechtold Marvin , Barzen Johanna , Leymann Frank , Mandl Alexander , Obst Julian , Truger Felix , Weder Benjamin 
Published: August 2023

Abstract
Noisy intermediate-scale quantum (NISQ) devices are restricted by their limited number of qubits and their short decoherence times. An approach addressing these problems is quantum circuit cutting. It decomposes the execution of a large quantum circuit into the execution of multiple smaller quantum circuits with additional classical postprocessing. Since these smaller quantum circuits require fewer qubits and gates, they are more suitable for NISQ devices. To investigate the effect of quantum circuit cutting in a quantum algorithm targeting NISQ devices, we design two experiments using the quantum approximate optimization algorithm (QAOA) for the Maximum Cut (MaxCut) problem and conduct them on state-of-the-art superconducting devices. Our first experiment studies the influence of circuit cutting on the objective function of QAOA, and the second evaluates the quality of results obtained by the whole algorithm with circuit cutting. The results show that circuit cutting can reduce the effects of noise in QAOA, and therefore, the algorithm yields better solutions on NISQ devices.