bluuebunny/crossref_metadata_2025_split huggingface dataset:
From root to shoot; Quantifying nematode tolerance inArabidopsis thalianaby high-throughput phenotyping of plant development
Authors: Willig Jaap-Jan , Sonneveld Devon , van Steenbrugge Joris J.M. , Deurhof Laurens , van Schaik Casper C. , Teklu Misghina G. , Goverse Aska , Lozano-Torres Jose L. , Smant Geert , Sterken Mark G. 
Published: March 2023

AbstractNematode migration, feeding site formation, withdrawal of plant assimilates, and activation of plant defence responses have a significant impact on plant growth and development. Plants display intraspecific variation in tolerance limits for root-feeding nematodes. Although disease tolerance has been recognised as a distinct trait in biotic interactions of mainly crops, we lack mechanistic insights. Progress is hampered by difficulties in quantification and laborious screening methods. We turned to the model plantArabidopsis thaliana, since it offers extensive resources to study the molecular and cellular mechanisms underlying nematode-plant interactions. Through imaging of tolerance-related parameters the green canopy area was identified as an accessible and robust measure for assessing damage due to cyst nematode infection. Subsequently, a high-throughput phenotyping platform simultaneously measuring the green canopy area growth of 960A. thalianaplants was developed. This platform can accurately measure cyst- and root-knot nematode tolerance limits inA. thalianathrough classical modelling of tolerance limits. Furthermore, real-time monitoring provided data for a novel view of tolerance, identifying a compensatory growth response. These findings show that our phenotyping platform will enable further studies into a mechanistic understanding of tolerance to below-ground biotic stress.HighlightThe mechanisms of tolerance to root-parasitic nematodes remain unknown. We developed a high-throughput phenotyping system that enables unravelling the underlying mechanisms of tolerance to nematodes.
Quality matters: stoichiometry of resources modulates spatial feedbacks in aquatic-terrestrial meta-ecosystems
Authors: Pichon Benôıt , Thébault Elisa , Lacroix Gérard , Gounand Isabelle 
Published: March 2023

AbstractSpecies dispersal and resource spatial flows greatly affect the dynamics of connected ecosystems. So far, research on meta-ecosystems has mainly focused on the quantitative effect of subsidy flows. Yet, resource exchanges at heterotrophic-autotrophic (e.g.,aquatic-terrestrial) ecotones display a stoichiometric asymmetry that likely matters for functioning. Here, we joined ecological stoichiometry and the meta-ecosystem framework to understand how subsidy stoichiometry mediates the response of the meta-ecosystem to subsidy flows. Our model results demonstrate that resource flows between ecosystems can induce a positive spatial feedback loop, leading to higher production at the meta-ecosystem scale by relaxing local ecosystem limitations (“spatial complementarity”). Furthermore, we show that spatial flows can also have an unexpected negative impact on production when accentuating the stoichiometric mismatch between local resources and basal species needs. This study paves the way for studies on the interdependancy of ecosystems at the landscape extent.Data:The code and the data, as well as a small tutorial to run the model are available on Github via Zenodo:https://doi.org/10.5281/zenodo.7733880
Skewed distribution of spines is independent of presynaptic transmitter release and synaptic plasticity and emerges early during adult neurogenesis
Authors: Rößler Nina , Jungenitz Tassilo , Sigler Albrecht , Bird Alexander , Mittag Martin , Rhee Jeong Seop , Deller Thomas , Cuntz Hermann , Brose Nils , Schwarzacher Stephan W. , Jedlicka Peter 
Published: March 2023

SummaryDendritic spines are crucial for excitatory synaptic transmission as the size of a spine head correlates with the strength of its synapse. The distribution of spine head sizes follows a lognormal-like distribution with more small spines than large ones. We analysed the impact of synaptic activity and plasticity on the spine size distribution in adult-born hippocampal granule cells from rats with induced homo- and heterosynaptic long-term plasticity in vivo and CA1 pyramidal cells from Munc-13-1-Munc13-2 knockout mice with completely blocked synaptic transmission. Neither induction of extrinsic synaptic plasticity nor the blockage of presynaptic activity degrades the lognormal-like distribution but changes its mean, variance and skewness. The skewed distribution develops early in the life of the neuron. Our findings and their computational modelling support the idea that intrinsic synaptic plasticity is sufficient for the generation, while a combination of intrinsic and extrinsic synaptic plasticity maintains lognormal like distribution of spines.
Mediation of learning orientation on market orientation and business performance: evidence from Brazilian Small and Medium Enterprises (SMEs)
Authors: Guerra Rodrigo Marques de Almeida , Camargo Maria Emilia 
Published: March 2023

PurposeThe aim of this study is to investigate the mediating effect of learning orientation on the market orientation and business performance of industrial Small and Medium Enterprises (SMEs) in the metal-mechanic and wine sectors in southern Brazil, an emerging economy country.Design/methodology/approachSurvey data were collected from 309 Brazilian managers of SMEs in the metal-mechanic and wine sectors. The study analyzed overall model fit and causal relationships by confirmatory factor analysis and structural equation modeling.FindingsThe survey results show that there is a positive and significant relationship between the variables market orientation, learning orientation and business performance in the investigated sectors. Learning orientation mediates the relationship between market orientation and business performance.Practical implicationsThis article provides insight to guide industrial managers of Brazilian SMEs in the metal-mechanic and wine sectors in a prosperous region with a thriving economy. The mediating effect of learning orientation can help managers in their commitment to learning, market vision and open-mindedness in teams that work with multiple orientations.Originality/valueFew studies focus on analyzing the mediating effect of learning orientation in industrial SMEs in the metal-mechanic and wine sectors. This article differs from others due to the relationships between the constructs, LO mediation over MO and BP, relevance of the investigated sectors for the region and multiple guidelines for managers of the investigated SMEs. Previous studies are scarce on the indirect effect of LO on MO and BP in developing countries.
There and back again: staff and service user perspectives on readmission to a secure mental health hospital
Authors: Whittaker Maria , Cook Andy , Marrocco Marisa , Osborne David 
Published: March 2023

Purpose
Readmission to hospital can be distressing, costly for the National Health Service (NHS) and legally it should be a last resort as it entails restriction of liberty. This study aims to develop an understanding of factors leading to readmission for a cohort of service users under the care of a community forensic mental health team (CFMHT) in England to consider how support could be improved to reduce incidence of future readmissions.

Design/methodology/approach
Thematic analysis was used to examine case recording relating to 13 service users who were readmitted to hospital within a specified time period. The same service users were invited to complete questionnaires regarding their views of what contributed to the readmission to cross-reference with themes identified.

Findings
The analysis of case notes produced eight sub-themes. These were sorted into three overarching themes, illustrating the challenges that service users face upon discharge from hospital, the sense they make of these challenges and the impact upon relational patterns, in particular with the CFMHT. Researchers highlight that the multiple challenges can increase service users’ sense of being under threat which can lead to distrust of professionals.

Practical implications
Practical suggestions arising from the study were fed back to the subject team and are listed at the end of the paper.

Originality/value
Findings from this study parallel those previously reported. This study contributes an inter-relational aspect of the factors and the central role of meaning-making in the path of recovery and building a life in the community.
Global challenge and opportunities for libraries and big data
Authors: Oladokun Bolaji David , Aboyade Modupe Aduke , Aboyade Wahab Akanmu 
Published: March 2023

Purpose
This study aims to find out the role of big data in the field of library and information science by considering the opportunities and challenges.

Design/methodology/approach
This study, which was conducted on a desk, examined the rise and significance of big data in the field of library and information science in Nigeria. Also, systematic literature review is done, exploring blogs and wikis to gather data on the use of big data.

Findings
This study emphasizes that as data is the primary component in the creation of information, professionals in the fields of library and information science must develop the knowledge and abilities necessary to support big data analysis. It was determined that offering and facilitating big data analysis would guarantee our place as a priceless and crucial resource in the digital workplace.

Originality/value
To the best of the authors’ knowledge, this study will be one of its kind to examine the role of big data in the field of library and information science profession. Furthermore, the results of the study will expose librarians and information professionals on the opportunities and challenges inherent in the use of big data technologies.
Elucidation of the effect of heat exposure on hair colored by permanent and semipermanent colorants using surface‐enhanced Raman spectroscopy
Authors: Steczkowski Mackenzi , Kurouski Dmitry 
Published: March 2023

AbstractConfirmatory identification of hair colorants can be used to establish a connection between a suspect and the crime science or demonstrate the absence of such connections. A growing body of evidence shows that surface‐enhanced Raman spectroscopy (SERS) could be a confirmatory, minimally destructive, and fully noninvasive analysis of hair colorants. In SERS, a signal that provide the information about the chemical structure of both permanent and semipermanent dyes present on hair is enhanced by a million‐fold using noble metal nanostructures. However, it is unclear whether the information of hair colorants can be revealed if hair was contaminated or exposed to harsh environments such as sunlight and heat. In this work, we determine the effect of a short‐ and long‐term heat exposure on SERS‐based analysis of hair colored with blue and red permanent and semipermanent dyes. We found that short and especially long‐term heat exposure at 220°C could alter chemical structure, and consequently SERS spectra, of permanent and semipermanent colorants. This thermal degradation of permanent dyes complicates their direct identification using SERS. We also found that partial least squares discriminant analysis can be used to overcome this issue allowing for highly accurate identification of both permanent and semipermanent dyes on colored hair that was exposed to 220°C for 6–12 min. These results show that heat exposure of colored hair should be strongly considered upon their SERS‐based examination to avoid both false positive or false negative identification of chemical dyes.
Rodent management in Aotearoa New Zealand: approaches and challenges to landscape‐scale control
Authors: INNES John G. , NORBURY Grant , SAMANIEGO Araceli , WALKER Susan , WILSON Deborah J. 
Published: March 2023

AbstractAotearoa—New Zealand has only four rodent species, all introduced. In order of arrival, they are Pacific rat Rattus exulans, brown rat R. norvegicus, house mouse Mus musculus, and black rat R. rattus. Rodent management in New Zealand aims mainly to conserve indigenous biodiversity rather than to protect crops or manage diseases, as is usual elsewhere. We describe four major “regimes” and one major vision for rodent control in New Zealand to meet ecological restoration objectives. Current challenges for island eradications are for large islands that are remote or populated by people. Aerial 1080 is the only large‐scale (tens of thousands of hectares) option for black rat control, but its application requires adjustment to counter subsequent rapid black rat repopulation. Unfenced “ecosanctuaries” (mean 720 ha) use ground‐based traps and poisons to target mainly black rats and face constant reinvasion. Ecosanctuaries with mammal‐resistant fences (up to 3500 ha) limit reinvasion and target more pest species and have enabled the return of previously extirpated taxa to the main islands. Predator Free 2050 aims to eradicate the rat species (but not mice) plus some other introduced mammals from New Zealand by 2050. This vision is not attainable with current tools, but research and experimental management is exploring techniques and technologies. The large scale (to 100 000 ha) at which black rats are now targeted for control to extremely low abundance seems to be unique to New Zealand.
Quaternary Intrusions from the Zhongjiannan Basin, South China Sea: Their Relationship with the Hainan Mantle Plume and Influence on Hydrocarbon Reservoirs
Authors: HE Yanxin , LIU Jianping , WANG Lei , TIAN Wei 
Published: March 2023

AbstractThe transportation of magma in sedimentary basins often occurs through extensive dyke‐sill networks. The role of sills on the plumbing system in rifted margins and the impact of sills on hydrocarbon reservoirs of prospective sedimentary basins has long been an area of great industrial interest and scientific debate. Based on 2D seismic reflection, we present data on how the sills emplaced to form a magmatic plumbing system of the volcanic system for the Zhongjiannan Basin (ZJNB). The results show that sixty‐nine sills and fourteen forced folds have been identified. The distribution and geometry of the sills suggest that magma flowed from west to east and then ascended to near the surface. The onlap relationship of the forced folds indicates that the timing of magmatic activities can be constrained at ca. 0.2 Ma. The spatial and temporal occurrences of intrusions imply that the strong post‐rift magmatism in ZJNB was associated with the Hainan mantle plume arising from the core‐mantle boundary. Furthermore, these forced folds could produce several types of hydrocarbon traps, due to accommodation through bending and uplift of the overlying rock and free surface, but it is critical to evaluate the effect of such emplacement when setting exploration targets.
The Paleoproterozoic and Neoproterozoic Carbon Cycle Promoted the Evolution of a Habitable Earth
Authors: LIU Zhicheng , ZHANG Lifei 
Published: March 2023

AbstractThe carbon cycle is an important process that regulates Earth's evolution. We compare two typical periods, in the Paleoproterozoic and Neoproterozoic, in which many geological events occurred. It remains an open question when modern plate tectonics started on Earth and how it has influenced the carbon cycle through time. In the Paleoproterozoic, intense weathering in a highly CO2 and CH4 rich atmosphere caused more nutritional elements to be carried into the ocean. Terrestrial input boosted high biological productivity, deposition of sediments and the formation of an altered oceanic crust, which may have promoted an increase in the oxygen content. Sediment lubrication and a decrease in mantle potential temperature made cold and deep subduction possible, which carried more carbon into the deep mantle. Carbon can be stored in the mantle as diamond and carbonated mantle rocks, being released by arc and mid‐ocean ridge outgassing at widely different times. From the Paleoproterozoic through the Neoproterozoic to the Phanerozoic, the carbon cycle has promoted the evolution of a habitable Earth.
Grassland management intensification affects the soil fauna in a subtropical highland
Authors: dos Peron Rafaela Alves Santos , Tomazelli Daniela , Kraft Elston , Baldissera Tiago Celso , Baretta Dilmar , Pinto Cassiano Eduardo , Goss‐Souza Dennis , de Oliveira Filho Luís Carlos Iuñes , Klauberg‐Filho Osmar 
Published: March 2023

AbstractThe conversion of natural grasslands to cultivated pastures can have a significant impact on the composition and structure of soil macro‐ and mesofauna groups, compromising the resilience of these organisms and the ecosystem services they provide. We studied the responses of these groups to increasing levels of soil disturbance across a gradient of four land management practices: Natural grassland (NG), Improved‐natural grassland (IG), Perennial‐cultivated pasture (PP), and Annual‐cultivated pasture (AP). The NG area had a higher abundance of macrofauna, greater dominance of certain groups, particularly Isoptera, and a lower abundance of mesofauna. On the other hand, the IG area had a higher abundance and diversity of macro‐ and mesofauna, with a lower dominance of specific groups. The PP area had a higher abundance of Coleoptera, Oligochaeta, and Hemiptera, whereas the AP area, despite soil disturbance, showed a higher abundance of mesofauna, particularly mites, Collembola, and Enchytraeidae, but lower diversity. Different grassland management practices have significantly altered the composition and structure of macro‐ and mesofauna groups, resulting in high dissimilarity between communities. We recommend IG as a more productive and sustainable alternative to the total replacement of natural vegetation (NG) with intensified converted pastures (PP and AP), as it maintains soil fauna diversity and ecosystem services.
Review article: The need for more efficient and patient‐oriented drug development pathways in NASH—setting the scene for platform trials
Authors: Pericàs Juan M. , Di Prospero Nicholas A. , Anstee Quentin M. , Mesenbrinck Peter , Kjær Mette S. , Rivera‐Esteban Jesús , Koenig Franz , Sena Elena , Pais Raluca , Manzano Ramiro , Genescà Joan , Tacke Frank , Ratziu Vlad ,   the EU‐PEARL NASH Investigators
Published: March 2023

SummaryBackground and AimsNon‐alcoholic steatohepatitis (NASH) constitutes a significant unmet medical need with a burgeoning field of clinical research and drug development. Platform trials (PT) might help accelerate drug development while lowering overall costs and creating a more patient‐centric environment. This review provides a comprehensive and nuanced assessment of the NASH clinical development landscape.MethodsNarrative review and expert opinion with insight gained during the EU Patient‐cEntric clinicAl tRial pLatforms (EU‐PEARL) project.ResultsAlthough NASH represents an opportunity to use adaptive trial designs, including master protocols for PT, there are barriers that might be encountered owing to distinct and sometimes opposing priorities held by these stakeholders and potential ways to overcome them. The following aspects are critical for the feasibility of a future PT in NASH: readiness of the drug pipeline, mainly from large drug companies, while there is not yet an FDA/EMA‐approved treatment; the most suitable design (trial Phase and type of population, e.g., Phase 2b for non‐cirrhotic NASH patients); the operational requirements such as the scope of the clinical network, the use of concurrent versus non‐concurrent control arms, or the re‐allocation of participants upon trial adaptations; the methodological appraisal (i.e. Bayesian vs. frequentist approach); patients' needs and patient‐centred outcomes; main regulatory considerations and the funding and sustainability scenarios.ConclusionsPT represent a promising avenue in NASH but there are a number of conundrums that need addressing. It is likely that before a global NASH PT becomes a reality, ‘proof‐of‐platform’ at a smaller scale needs to be provided.
Low B‐cell content is associated with a CD73‐low tumour microenvironment and unfavourable prognosis in classic Hodgkin lymphoma
Authors: Grund Johanna , Iben Katharina , Reinke Sarah , Bühnen Ina , Plütschow Annette , Müller‐Meinhard Berit , Garcia Marquez Maria A. , Schlößer Hans A. , von Tresckow Bastian , Kellermeier Fabian , Borchmann Peter , Engert Andreas , Bröckelmann Paul J. , Klapper Wolfram 
Published: March 2023

SummaryB‐cell content in the tumour microenvironment (TME) of classic Hodgkin lymphoma (HL) is known to be associated with prognosis. Here we demonstrate that whole slide image analysis using routinely available slides predicts outcomes in patients treated with ABVD in a prospective trial with a high B‐cell content being associated with a favourable prognosis. B cells in the TME did not correlate with B cells in peripheral blood. In the TME maturation, stages of B cells (naive and memory) were consistent. However, we detected down‐regulation of CD73 in HL with low B cells suggestive of an antibody‐independent function of B cells in the TME of HL.
Procrastination and health: A longitudinal test of the roles of stress and health behaviours
Authors: Sirois Fuschia M. , Stride Christopher B. , Pychyl Timothy A. 
Published: March 2023

AbstractObjectivesProcrastination is a common form of self‐regulation failure that a growing evidence base suggests can confer risk for poor health outcomes, especially when it becomes habitual. However, the proposed linkages of chronic procrastination to health outcomes have not been tested over time or accounted for the contributions of higher‐order personality factors linked to both chronic procrastination and health‐related outcomes. We addressed these issues by examining the role of chronic procrastination in health outcomes over time in which the hypothesized links of procrastination to health problems operate via stress and health behaviours.DesignThree‐wave longitudinal study with 1‐month intervals.MethodsParticipants (N = 379) completed measures of trait procrastination at Time 1, and measures of health behaviours, stress and health problems at each time point, in a lab setting.ResultsProcrastination and the health variables were inter‐related in the expected directions across the three assessments. Chronic procrastination was positively associated with stress and negatively with health behaviours at each time point. Path analysis testing a cross‐lagged longitudinal mediation model found an indirect relationship operating between procrastination and health problems via stress, after accounting for the contributions of conscientiousness and neuroticism.ConclusionsThis research extends previous work by demonstrating that the links between chronic procrastination and poor health are accounted for mainly by higher stress, after accounting for other key traits, and that these associations are robust over time. The findings are discussed in terms of the importance of addressing habitual self‐regulation failure for improving health.