bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin-interfaced colorimetric microfluidic devices for on-demand sweat analysis
Authors: Liu Weiyi , Cheng Huanyu , Wang Xiufeng 
Published: September 2023

AbstractAs sweat biomarker levels are continuously changing over metabolism and daily activities, pathological and physiological processes can be dynamically analyzed by wearable devices. The colorimetric skin-interfaced microfluidic devices that do not have external circuit modules exhibit enhanced deformability with a small footprint. However, it is difficult to achieve sampling over time and self-feedback for closed-loop systems. This review summarizes recent advances in microfluidic valves for biofluid management and chrono-sampling, as well as active triggers in microfluidics self-feedback. After enumerating the current limitations in temporal resolution and reliability, we further point out a few potential feasible strategies for future developments.
Mutational spectrum and clinical features of GBA1 variants in a Chinese cohort with Parkinson’s disease
Authors: Zhou Yangjie , Wang Yige , Wan Juan , Zhao Yuwen , Pan Hongxu , Zeng Qian , Zhou Xun , He Runcheng , Zhou Xiaoxia , Xiang Yaqin , Zhou Zhou , Chen Bin , Sun Qiying , Xu Qian , Tan Jieqiong , Shen Lu , Jiang Hong , Yan Xinxiang , Li Jinchen , Guo Jifeng , Tang Beisha , Wu Heng , Liu Zhenhua 
Published: September 2023

AbstractGBA1 variants are important risk factors for Parkinson’s disease (PD). Most studies assessing GBA1-related PD risk have been performed in European-derived populations. Although the coding region of the GBA1 gene in the Chinese population has been analyzed, the sample sizes were not adequate. In this study, we aimed to investigate GBA1 variants in a large Chinese cohort of patients with PD and healthy control and explore the associated clinical characteristics. GBA1 variants in 4034 patients and 2931 control participants were investigated using whole-exome and whole-genome sequencing. The clinical features of patients were evaluated using several scales. Regression analysis, chi-square, and Fisher exact tests were used to analyze GBA1 variants and the clinical symptoms of different groups. We identified 104 variants, including 8 novel variants, expanding the spectrum of GBA1 variants. The frequency of GBA1 variants in patients with PD was 7.46%, higher than that in the control (1.81%) (P < 0.001, odds ratio [OR] = 4.38, 95% confidence interval [CI]: 3.26–5.89). Among patients, 176 (4.36%) had severe variants, 34 (0.84%) carried mild variants, three (0.07%) had risk variants, and 88 (2.18%) carried unknown variants. Our study, for the first time, found that p.G241R (P = 0.007, OR = 15.3, 95% CI: 1.25–261.1) and p.S310G (P = 0.005, OR = 4.86, 95% CI: 1.52–28.04) variants increased the risk of PD. Patients with GBA1 variants exhibited an earlier onset age and higher risk of probable rapid-eye-movement sleep behavior disorder, olfactory dysfunction, depression, and autonomic dysfunction than patients without GBA1 variants.
Contrasting allelic effects for pistachio salinity tolerance in juvenile and mature trees
Authors: Sheikhi Abdollatif , Arab Mohammad M. , Davis Matthew , Palmer William J. , Michelmore Richard , Brown Pat J. 
Published: September 2023

AbstractBreeding perennial tree crops often requires prediction of mature performance from juvenile data. To assess the utility of juvenile screens to predict salinity tolerance of mature pistachio trees, we compared performance of 3-month ungrafted seedlings and 4-year-old grafted rootstocks under salinity stress. The QTL allele associated with higher salt exclusion from seedling leaves conferred lower growth in saline field conditions, suggesting that mapping QTL in seedlings may be easier than discerning the optimal allele for field performance.
Accuracy and stability of accommodation and vergence responses during sustained near tasks in uncorrected hyperopes
Authors: Ntodie Michael , Saunders Kathryn , Little Julie-Anne 
Published: September 2023

AbstractThis study investigated the accuracy and stability of accommodative and vergence functions in children with and without hyperopia while engaged in two sustained near tasks. The sustained accommodative and vergence characteristics of participants without refractive correction (n = 92, aged 5–10 years) with and without hyperopia (defined as cycloplegic retinoscopy ≥  + 1.00D and less than + 5.00D) were measured using eccentric infrared photorefraction (PowerRef 3; PlusOptix, Germany). Binocular measures of accommodation and eye position were recorded while participants engaged in 2 tasks at 25 cm for 15 min each: (1) reading small print on an Amazon Kindle and (2) watching an animated movie on liquid crystal display screen. Comprehensive visual assessment, including measurement of presenting visual acuity, amplitude of accommodation, and stereoacuity was conducted. The magnitude of accommodative and vergence responses was not related to refractive error (P > 0.05). However, there were inter-task differences in the accuracy and stability of the accommodative responses across refractive groups (P < 0.05). The relationship between accommodation and vergence was not significant in both tasks (P > 0.05). However, increased accommodative and vergence instabilities were associated with total accommodative response (P < 0.05). Despite having greater accommodative demand, uncorrected hyperopes accommodate comparably to emmetropic controls. However, uncorrected hyperopes have increased instabilities in their accommodative and vergence responses, which may adversely impact their visual experience.
Predicting climate heating impacts on riverine fish species diversity in a biodiversity hotspot region
Authors: Makki Toktam , Mostafavi Hossein , Matkan Ali Akbar , Valavi Roozbeh , Hughes Robert M. , Shadloo Shabnam , Aghighi Hossein , Abdoli Asghar , Teimori Azad , Eagderi Soheil , Coad Brian W. 
Published: September 2023

AbstractCo-occurring biodiversity and global heating crises are systemic threats to life on Earth as we know it, especially in relatively rare freshwater ecosystems, such as in Iran. Future changes in the spatial distribution and richness of 131 riverine fish species were investigated at 1481 sites in Iran under optimistic and pessimistic climate heating scenarios for the 2050s and 2080s. We used maximum entropy modeling to predict species’ potential distributions by hydrologic unit (HU) occupancy under current and future climate conditions through the use of nine environmental predictor variables. The most important variable determining fish occupancy was HU location, followed by elevation, climate variables, and slope. Thirty-seven species were predicted to decrease their potential habitat occupancy in all future scenarios. The southern Caspian HU faces the highest future species reductions followed by the western Zagros and northwestern Iran. These results can be used by managers to plan conservational strategies to ease the dispersal of species, especially those that are at the greatest risk of extinction or invasion and that are in rivers fragmented by dams.
Spatial–temporal evolution and spatial spillover of the green efficiency of urban construction land in the Yangtze River Economic Belt, China
Authors: Zhou Jialiang 
Published: September 2023

AbstractThere are urgent ecological and environmental problems in the process of the utilization of urban construction land, promoting green utilization of construction land is conducive to urban sustainable development and high-quality economic development. Based on the panel data of 108 prefecture-level and above cities in the Yangtze River Economic Belt, China from 2003 to 2017, this paper uses the super-efficiency SBM model to measure the green efficiency of urban construction land (GEUCL), analyzes its spatial–temporal evolution characteristics, and constructs the spatial autoregressive model to study its spatial spillover effects from the perspective of urban hierarchy. It is found that, in terms of temporal variation, the average efficiency value shows a fluctuating upward trend during the study period, rising from 0.27 in 2003 to 0.39 in 2017, the cumulative growth rate is 44.44%, with an average annual growth rate of 3.14%. In terms of spatial distribution characteristics, during the study period, the number of medium-efficiency and high-efficiency cities increases significantly, while the number of low-efficiency cities decreases sharply; high-efficiency cities always present scattered distribution, while medium-efficiency cities change from scattered distribution to agglomeration distribution. In addition, GEUCL has significantly positive spatial spillover effects between neighboring cities of different grades and between neighboring cities of the same grade, among them, the increase of GEUCL in higher-grade cities has significantly positive spatial spillover effects on that in adjacent lower-grade cities; the increase of GEUCL in lower-grade cities has significantly positive spatial spillover effects on that in neighboring higher-grade cities; GEUCL has significantly positive spatial spillover effects between neighboring cities of the same grade.
Acceptorless cross-dehydrogenative coupling for C(sp3)-H heteroarylation mediated by a heterogeneous GaN/ketone photocatalyst/photosensitizer system
Authors: Kang Hyotaik , Tan Lida , Han Jing-Tan , Huang Chia-Yu , Su Hui , Kavun Aleksei , Li Chao-Jun 
Published: September 2023

AbstractAlkanes are naturally abundant chemical building blocks that contain plentiful C(sp3)-H bonds. While inert, the activation of C(sp3)-H via hydrogen atom abstraction (HAT) stages an appealing approach to generate alkyl radicals. However, prevailing shortcomings include the excessive use of oxidants and alkanes that impede scope. We herein show the use of gallium nitride (GaN) as a non-toxic, recyclable, heterogeneous photocatalyst to enable alkyl C(sp3)-H in conjunction with the catalytic use of simple photosensitizer, benzophenone, to promote the desired alkyl radical generation. The dual photocatalytic cycle enables cross-dehydrogenative Minisci alkylation under mild and chemical oxidant-free conditions.
Entanglement-enhanced optomechanical sensor array with application to dark matter searches
Authors: Brady Anthony J. , Chen Xin , Xia Yi , Manley Jack , Dey Chowdhury Mitul , Xiao Kewen , Liu Zhen , Harnik Roni , Wilson Dalziel J. , Zhang Zheshen , Zhuang Quntao 
Published: September 2023

AbstractSqueezed light has long been used to enhance the precision of a single optomechanical sensor. An emerging set of proposals seeks to use arrays of optomechanical sensors to detect weak distributed forces, for applications ranging from gravity-based subterranean imaging to dark matter searches; however, a detailed investigation into the quantum-enhancement of this approach remains outstanding. Here, we propose an array of entanglement-enhanced optomechanical sensors to improve the broadband sensitivity of distributed force sensing. By coherently operating the optomechanical sensor array and distributing squeezing to entangle the optical fields, the array of sensors has a scaling advantage over independent sensors (i.e., $$\sqrt{M}\to M$$

M

→
M
, where M is the number of sensors) due to coherence as well as joint noise suppression due to multi-partite entanglement. As an illustration, we consider entanglement-enhancement of an optomechanical accelerometer array to search for dark matter, and elucidate the challenge of realizing a quantum advantage in this context.
Seasonal stratification and complex local dynamics control the sub-surface structure of marine heatwaves in Eastern Australian coastal waters
Authors: Schaeffer Amandine , Sen Gupta Alex , Roughan Moninya 
Published: September 2023

AbstractMarine heatwaves are extreme seawater temperature events that can have severe impacts on marine life. The extent of the ecological damage depends not only on the easily observed surface signature but on the marine heatwave structure at depth. However, due to a paucity of in situ sub-surface observations the vertical structure of marine heatwaves is poorly understood. Here we analyse the sub-surface coherence and controls of marine heatwaves using one of the world’s longest (28 years) records of daily sub-surface ocean temperature off Sydney, Australia. We show that seasonal stratification, large-scale circulation and local downwelling processes control the vertical coherence of coastal marine heatwaves. We define three classes of marine heatwaves which can extend through the water column, form in the shallow surface layer, or sub-surface independently, and are therefore not always evident in surface data. We conclude that sub-surface data need to be considered in monitoring marine heatwaves in coastal areas where maximum biological damage is reported.
B- and T-lymphocyte attenuator could be a new player in accelerated atherosclerosis associated with chronic kidney disease
Authors: Dolade Nuria , Rayego-Mateos Sandra , Garcia-Carrasco Alicia , Guerin Maryse , Martín-Ventura Jose-Luis , Ruiz-Ortega Marta , Tharaux Pierre-Louis , Valdivielso Jose Manuel 
Published: September 2023

Abstract
Background: In chronic kidney disease (CKD), cardiovascular morbi-mortality is higher than in general population. Atherosclerotic cardiovascular disease is accelerated in CKD, but specific CKD-related risk factors for atherosclerosis are unknown.
Methods: CKD patients from the NEFRONA study were used. We performed mRNA array from blood of patients free from atheroma plaque at baseline, with (n=10) and without (n=10) de novo atherosclerotic plaque development 2 years later. Selected mRNA candidates were validated in a bigger sample (n=148). Validated candidates were investigated in vivo in an experimental model of CKD-accelerated atherosclerosis, and in vitro in murine macrophages.
Results: mRNA array analysis showed 92 up-regulated and 67 down-regulated mRNAs in samples from CKD patients with de novo plaque development. The functional analysis pointed to a paramount role of the immune response. The validation in a bigger sample confirmed that B- and T-lymphocyte co-inhibitory molecule (BTLA) down-regulation was associated with de novo plaque presence after 2 years. However, BTLA down-regulation was not found to be associated with atherosclerotic progression in patients with plaque already present at baseline. In a model of CKD-accelerated atherosclerosis, mRNA and protein expression levels of BTLA were significantly decreased in blood samples and atheroma plaques. Plaques from animals with CKD were bigger, had more infiltration of inflammatory cells, higher expression of IL6 and IL17 and less presence of collagen than plaques from control animals. Incubation of macrophages with rat uremic serum decreased BTLA expression.
Conclusions: BTLA could be a potential biomarker or therapeutic target for atherosclerosis incidence in CKD patients.
The Effect of a Specialized Training Program on the Knowledge of First Responders About People With Communication Disabilities
Authors: Rang Mariesa , Mankey Sharon , Dirette Diane Powers 
Published: September 2023

Purpose:
Individuals with disabilities experience emergencies more often than those without disabilities; people with complex communication needs are even more at risk. Emergency first responders, such as police officers, firefighters, and emergency medical technicians, do not receive adequate training to respond to emergencies for this vulnerable community.

Method:
Using a retrospective analysis of pre- and posttests, data from 692 participants were analyzed to determine knowledge change following a 90-min training session on how emergency first responders should communicate with individuals who have complex communication needs. An analysis was first conducted at the whole group level followed by an analysis controlling for occupation.

Results:
Descriptive and inferential statistics revealed a statistically significant difference in change in knowledge across all participants, though controlling for occupation did not reveal a statistically significant change.

Conclusions:
These results indicated the training was successful across all participants regardless of occupation and should be evaluated in other geographical areas. Future research should include a qualitative exploration of emergency first responders' lived experiences in working with this particular group of individuals to ensure the training adequately addresses their needs.
CROCODILE
Authors: Hayoz J. , Cugno G. , Quanz S. P. , Patapis P. , Alei E. , Bonse M. J. , Dannert F. A. , Garvin E. O. , Gebhard T. D. , Konrad B. S. , Sartori L. F. 
Published: September 2023

Context.The investigation of the atmospheres of closely separated, directly imaged gas giant exoplanets is challenging due to the presence of stellar speckles that pollute their spectrum. To remedy this, the analysis of medium- to high-resolution spectroscopic data via cross-correlation with spectral templates (cross-correlation spectroscopy) is emerging as a leading technique.Aims.We aim to define a robust Bayesian framework combining, for the first time, three widespread direct-imaging techniques, namely photometry, low-resolution spectroscopy, and medium-resolution cross-correlation spectroscopy in order to derive the atmospheric properties of close-in directly imaged exoplanets. Current atmospheric characterisation frameworks are indeed either not compatible with all three observing techniques or they lack the commitment to efficient sampling strategies that allow high-dimensional forward models.Methods.Our frameworkCROCODILE(cross-correlation retrievals of directly imaged self-luminous exoplanets) naturally combines the three techniques by adopting adequate likelihood functions. To validate our routine, we simulated observations of gas giants similar to the well-studiedβPictoris b planet and we explored the parameter space of their atmospheres to search for potential biases.Results.We obtain more accurate measurements of atmospheric properties when combining photometry, low- and medium-resolution spectroscopy into atmospheric retrievals than when using the techniques separately as is usually done in the literature. Indeed, the combined fit is, on average, 20% more accurate than fitting only medium-resolution cross-correlation spectroscopy. We find that medium-resolution (R≈ 4000)K-band cross-correlation spectroscopy alone is not suitable to constrain the atmospheric properties of our synthetic datasets; however, this problem disappears when simultaneously fitting photometry throughout theYandMbands and low-resolution (R≈ 60) spectroscopy between theYandHbands. Our thorough testing demonstrates that free chemistry is a suitable forward model to retrieve the atmospheric thermal and chemical properties of cloudless gas giants at chemical equilibrium.Conclusions.CROCODILEprovides a robust statistical framework to interpret medium-resolution spectroscopic data of close-in directly imaged exoplanets, where speckles originating from stellar stray light render the extraction of the continuum difficult. Our framework allows the atmospheric characterisation of directly imaged exoplanets using the high-quality spectral data that will be provided by the new generation of instruments such as the Enhanced Resolution Imager and Spectrograph (ERIS) at the Very Large Telescope, the Mid-Infrared Instrument (MIRI) aboard theJames WebbSpace Telescope, and in the future the Mid-infrared ELT Imager and Spectrograph (METIS) at the Extremely Large Telescope.
CoCCoA: Complex Chemistry in hot Cores with ALMA
Authors: Chen Y. , van Gelder M. L. , Nazari P. , Brogan C. L. , van Dishoeck E. F. , Linnartz H. , Jørgensen J. K. , Hunter T. R. , Wilkins O. H. , Blake G. A. , Caselli P. , Chuang K.-J. , Codella C. , Cooke I. , Drozdovskaya M. N. , Garrod R. T. , Ioppolo S. , Jin M. , Kulterer B. M. , Ligterink N. F. W. , Lipnicky A. , Loomis R. , Rachid M. G. , Spezzano S. , McGuire B. A. 
Published: September 2023

Context. Complex organic molecules (COMs), especially the oxygen-bearing species, have been observed to be abundant in the gas phase toward low-mass and high-mass protostars. Deep line surveys have been carried out only for a limited number of well-known star-forming regions using the Atacama Large Millimeter/submillimeter Array (ALMA), which has unprecedented resolution and sensitivity, and statistical studies on oxygen-bearing COMs (O-COMs) in a large sample of high-mass protostars using ALMA are still lacking.
Aims. We aim to determine the column density ratios of six O-COMs with respect to methanol (CH3OH) in a sample of 14 high-mass protostellar sources in order to investigate their origin through ice and/or gas-phase chemistry. The selected species are: acetalde-hyde (CH3CHO), ethanol (C2H5OH), dimethyl ether (DME; CH3OCH3), methyl formate (MF; CH3OCHO), glycolaldehyde (GA; CH2OHCHO), and ethylene glycol (EG; (CH2OH)2).
Methods. We fit the spectra of 14 high-mass sources observed as part of the Complex Chemistry in hot Cores with ALMA (CoCCoA) survey and derived the column densities and excitation temperatures of the six selected O-COMs. We used the minor isotopologue of methanol CH318OH to infer the column density of the main isotopologue CH3OH, of which the lines are generally optically thick. We compared our O-COM ratios with those of five low-mass protostars studied with ALMA from the available literature as well as with the results from experiments and simulations.
Results. Although the CoCCoA sources have different morphologies and brightness in their continuum and methanol emission, the O-COM ratios with respect to methanol have very similar values in the high-mass and low-mass samples. The DME and MF have the highest and most constant ratios within one order of magnitude, while the other four species have lower ratios and exhibit larger scatter by one to two orders of magnitude. The ratio between DME and MF is close to one, which agrees well with previous observational findings. Current simulations and experiments can reproduce most observational trends with a few exceptions. For example, they tend to overestimate the abundance of ethanol and GA with respect to methanol.
Conclusions. The constant column density ratios of the selected O-COMs among the low- and high-mass sources suggest that these species are formed in similar environments during star formation, probably on icy dust grains in the pre-stellar stages. Where deviations are found, hypotheses exist to explain the differences between observations, simulations, and experiments, such as the involvement of gas-phase chemistry and different emitting areas of molecules.
Transarterielle periartikuläre Embolisation (TAPE): klinischer Einsatz und aktuelle Entwicklungen
Authors: Freyhardt Patrick , Katoh Marcus 
Published: September 2023

ZusammenfassungObwohl bei der transarteriellen periartikulären Embolisation (TAPE) noch viele Aspekte erforscht werden müssen, findet sie eine zunehmende Verbreitung und Akzeptanz bei der Behandlung von
Gelenkschmerzen. Diese Arbeit stellt den aktuellen Stand vor, benennt mögliche Indikationen, beschreibt die interventionelle Technik und fasst die in der Literatur verfügbaren Ergebnisse
zusammen.