bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Click’‐Derived 1,2,3‐Triazolium Salts Featuring a 4‐Halo‐phenyl Group: Precursors for Heterobimetallic Complexes
Authors: Tiwari Chandra Shekhar , Mathoor Illam Praseetha , Rit Arnab 
Published: June 2023

AbstractThe ‘click’‐derived 1,2,3‐triazolium salts [L1/L2‐H]I (1‐(4‐iodo/bromo‐phenyl)‐1H‐1,2,3‐triazolium salt) featuring two distinct coordination sites, one via oxidative addition and other via classical deprotonation cum metalation, were designed and explored towards the synthesis of various mono‐ and bimetallic complexes. Accordingly, a series of well‐characterized 1,2,3‐triazol‐5‐ylidene coordinated cyclometalated transition metal complexes (1–3) were obtained. However, these complexes were found to be ineffective in accessing the desired heterobimetallic complexes. Nevertheless, same ligand systems readily underwent oxidative addition with Pd0 metal precursors, to give the PdII complexes 4/5, and the considerable change and reversal in chemical shift values of the triazole C4/C5‐backbone protons (C4‐H being downfield shifted than that of C5‐H) of these oxidatively added PdII complexes were detected. The PdII complex 5 with chelating DPPE was finally successfully applied for the synthesis of the heterobimetallic PdII‐RuII complex 6 and 2D NMR analyses, as well as DFT calculations supported the formation of the rare C4/C5‐unprotected 1,2,3‐triazol‐4‐ylidene coordinated RuII‐complex.
Event‐triggered fuzzy adaptive control of incommensurate fractional order nonlinear systems
Authors: Gong Dianjun , Wang Yong 
Published: June 2023

AbstractThis paper focuses on the event‐triggered control of nonstrict‐feedback incommensurate fractional order systems with external disturbances. To release more communication resources and reduce the triggered time instant, we adopt the relative‐threshold‐based event‐triggered strategy and prove that the Zeno behavior does not exist. We utilize the fuzzy systems to approximate the nonlinear systems and design an adaptive update law to estimate the approximation errors and external disturbances. To conquer the dimension explosion phenomenon in the backstepping process, we design a fractional order filter and apply the dynamic surface control technique. The closed‐loop system is semiglobally stable and the tracking error converges to a small neighborhood of equilibrium point under the proposed control approach. Finally, the validity of the developed controller is verified by the simulation examples.
Robust iterative learning control via adaptive backstepping for oscillation displacement system of continuous casting mold driven by a servo motor
Authors: Li Jianxiong , Li Zhi , Gao Chongyi , Fang Yiming 
Published: June 2023

AbstractIn order to solve the tracking problem of oscillation displacement system of continuous casting mold driven by a servo motor in the present of the time‐varying load, parameter uncertainties, unknown dynamics and external disturbances, a robust iterative learning control (ILC) via adaptive backstepping is proposed in this paper. Firstly, backstepping technique is used to design controller due to the mismatched disturbances. Secondly, the periodic component of the lumped disturbances is estimated by ILC method, while the aperiodic component is attenuated by switching term with adaptive gain. In addition, a time‐varying boundary layer approach is employed to overcome the identical initial condition limitation of the ILC. Through a proper composite energy function, the convergence of the closed‐loop system is analyzed. Finally, simulation and experimental results are given to illustrate the effectiveness of the proposed method.
Kinematical and ellipsoidal properties of K dwarfs in the solar neighborhood of the Gaia era
Authors: Elsanhoury W. H. , Al‐Johani Amnah S. 
Published: June 2023

AbstractThe study reports velocity ellipsoid parameters including the kinematical properties of K dwarf stars. Herein, two samples of K dwarf stars are presented with the solar neighborhood ( pc) for high (; 106 points) and low galactic latitudes (; 199 points). We calculated spatial velocities (, , and ; km s) along the galactic coordinates and the velocity dispersion (, , ; km s), the vertex longitude (), which have often differed significantly from zero like many of our analyses, i.e., (; 106 points) and (; 199 points). Moreover, we computed the solar motion, i.e., km s, and other solar elements (e.g., , , , and ). Finally, we estimated Oort's constants, i.e., km s kpc and ‐ km s kpc, both indicating that the rotational velocity was km s.
Similar but distinct: The impact of biomechanical forces and culture age on the production, cargo loading, and biological efficacy of human megakaryocytic extracellular vesicles for applications in cell and gene therapies
Authors: Thompson Will , Papoutsakis Eleftherios Terry 
Published: June 2023

AbstractMegakaryocytic extracellular vesicles (MkEVs) promote the growth and megakaryopoiesis of hematopoietic stem and progenitor cells (HSPCs) largely through endogenous miR‐486‐5p and miR‐22‐3p cargo. Here, we examine the impact of biomechanical force and culture age/differentiation on the formation, properties, and biological efficacy of MkEVs. We applied biomechanical force to Mks using two methods: shake flask cultures and a syringe pump system. Force increased MkEV production in a magnitude‐dependent manner, with similar trends emerging regardless of whether flow cytometry or nanoparticle tracking analysis was used for MkEV counting. Both methods produced MkEVs that were relatively depleted of miR‐486‐5p and miR‐22‐3p cargo. However, while the shake flask‐derived MkEVs were correspondingly less effective in promoting megakaryocytic differentiation of HSPCs, the syringe pump‐derived MkEVs were more effective in doing so, suggesting the presence of unique, unidentified miRNA cargo components. Higher numbers of MkEVs were also produced by “older” Mk cultures, though miRNA cargo levels and MkEV bioactivity were unaffected by culture age. A reduction in MkEV production by Mks derived from late‐differentiating HSPCs was also noted. Taken together, our results demonstrate that biomechanical force has an underappreciated and deeply influential role in MkEV biology, though that role may vary significantly depending on the nature of the force. Given the ubiquity of biomechanical force in vivo and in biomanufacturing, this phenomenon must be grappled with before MkEVs can attain clinical relevance.
Regarding a human costoscapular joint by Prof. Dr. H. von Luschka (1870): A translation
Authors: Somerson Jeremy S. , Jung Beate , Stegink‐Jansen Caroline W. 
Published: June 2023

AbstractKnowledge of variant anatomy was important during the time of Dr. Hubert von Luschka (1820–1875) and continues to be of relevance in current practice to prevent medical and surgical errors and to improve patient outcomes. Dr. H. von Luschka described an anatomical variant observed in the left scapula of a 40‐year‐old male: a connection between the medial superior angle of the scapula, piercing through the serratus posterior muscle to connect via a synovial capsule to the articular surface of the thoracic wall. The clinical relevance of this so‐called “Luschka's tubercle” of the shoulder continues to be discussed. This translation is intended to broaden access to this hallmark manuscript to a wide audience of English readers. The introduction places the manuscript in the context of historical and current discussions. Three authors, all proficient in the German and English languages and educated in the anatomy of the shoulder, conducted the translation. The skeletal process that is part of the described joint structure appears similar to what is now called Luschka's tubercle. The full structure, including its connecting parts, are not currently included in anatomical nomenclature. In conclusion, Luschka's text and named tubercle continue to contribute to the discussion of scapulothoracic joint disorders.
KCND2: A prognostic biomarker and regulator of immune function in gastric cancer
Authors: Zhou Hongying , Su Dan , Chen Yun , Zhang Yiwen , Huang Ping 
Published: June 2023

AbstractBackgroundGastric cancer is a highly heterogeneous disease, which makes it challenging to develop effective targeted therapies. Although the potassium voltage‐gated channel subfamily D (KCND) channels, particularly KCND2 (also known as Kv4.2), have found evidence of involvement in the occurrence and development of various cancers, there are still some limitations in our understanding of KCND2's roles in gastric cancer.MethodsWe analyzed the correlation between KCND2 expression and clinical features as well as immune infiltration using the Cancer Genome Atlas (TCGA) database. Functional assays of KCND2 were conducted using Cell counting Kit‐8 (CCK8), clone formation assay and cell cycle analysis. Additionally, immunofluorescence, flow cytometry and quantitative real‐time polymerase chain reaction (qRT‐PCR) techniques were used to investigate tumor proliferation and immune cell infiltration at different levels of KCND2 expression in vivo.ResultsKCND2 was markedly elevated in gastric cancer and its expression appeared to link to different grades, T stages, and N stages. In addition, KCND2 was an independent predictor of prognosis, and its elevated levels in TCGA database revealed a more unfavorable prognosis for patients with gastric cancer. KCND2 strengthened the viability at the cellular level by boosting the proliferation of gastric cancer cells and reducing their death rate. Additionally, it also highlights that KCND2 the abilities of proliferating of gastric cancer cells by stimulating NF‐κB both in cell and animal levels. In addition, the findings provided proof that in animal levels, KCND2 might regulate the immune system by associating with promoting M2 macrophages, which are known to play critical roles in cancer progression. Mechanistically, KCND2 was found to lead to the infiltration of M2 macrophages through activation of NF‐κB, ultimately promoting the advancement of gastric cancer.ConclusionOverall, these findings suggest that KCND2 is likely to be available as an underlying therapeutic target for gastric cancer.
Optimizing the Production of Antioxidant and Antibacterial Alkaloids from Macleaya cordata by Subcritical Water Extraction Technology
Authors: Zhang Jianhui , Chen Jin , Zhao Wenhua , Wang Jun , Pan Xuexue , Lai Meiyun , Nguemdjo Chimeze V. Wilfried , Pameté Emmanuel 
Published: June 2023

AbstractIn this work, the subcritical water extraction technology was used to extract alkaloids from Macleaya cordata, and the effects of extraction temperature and time on its yield were investigated to find the best extraction conditions. Moreover, the antioxidant capacity and antibacterial activity of Macleaya cordata extract were studied. Furthermore, through the single‐factor method, it was found that properly increasing the extraction temperature and prolonging the extraction time was conducive to increasing alkaloid yield. Still, a considerable amount of alkaloids might be decomposed by heat, resulting in a decrease in their yield. The results showed that the optimal extraction temperature of alkaloids from Macleaya cordata with subcritical water is 190 °C, the time is 45 min, and the corresponding maximum yield is 35.19±0.12 mg/g (sanguinarine equivalent in raw materials). In addition, the antioxidation and bacteriostasis abilities of subcritical water extract are better than those of traditional hot water extract, indicating that it is a feasible method to extract alkaloids from Macleaya cordata with subcritical water.
Preparation and Antioxidant Activity of Acetylated Mung Bean Peel Polysaccharides
Authors: Chen Quan , Zhang Wenting , Huang Gangliang 
Published: June 2023

AbstractMung bean peel polysaccharides are one of the main active components in mung bean peel. Acetylated mung bean peel polysaccharides were prepared by extracting and acetylating them, and characterized by infrared and ultraviolet methods to preliminarily understand the structural characteristics and activity of acetylated mung bean peel polysaccharides. Acetylation modification can improve the structure of polysaccharides, thereby causing changes in their properties. The product obtained after acetylation modification exhibited new characteristic absorption peaks at 1732 cm−1, and the scavenging ability of hydroxyl radicals was improved. Therefore, acetylation modification of mung bean peel polysaccharides could enhance the activity by improving the structure, which provided an experimental basis for the application of mung bean peel polysaccharides.
Elsholblanosides A−D, Four New Oleuropeic Acid Derivatives Isolated from Elsholtzia blanda and Their Inhibition of NO Production in LPS‐activated RAW264.7 Cells
Authors: Thi Dung Duong , Thi Trang Do , Hai yen Pham , Huy Hoang Nguyen , Huu Tai Bui , Van Kiem Phan 
Published: June 2023

AbstractPhytochemical investigation on the aerial parts of Elsholtzia blanda Benth. afforded four new oleuropeic acid derivatives (1–4), named as elsholblanosides A−D, respectively, together with 11 known compounds (5–15). Their structures were determined based on extensive analyses of HR‐ESI‐MS, 1D and 2D NMR, and ECD spectra. Compounds 1–4 and 14 showed moderate NO production inhibition in LPS‐activated RAW264.7 cells with their IC50 values ranging from 23.2 to 86.33 μM, compared to that of the positive control compound, dexamethasone, IC50 value of 16.9 μM.
Pretreatment with P2Y12 inhibitors in ST‐elevation myocardial infarction: A systematic review and meta‐analysis
Authors: Gewehr Douglas Mesadri , Carvalho Pedro Emanuel de Paula , Dagostin Caroline Serafim , Cardoso Rhanderson , Kubrusly Taiane Belinati Loureiro , Kubrusly Fernando Bermudez , Kubrusly Luiz Fernando 
Published: June 2023

AbstractBackgroundPretreatment with oral P2Y12 inhibitors is a standard practice for ST‐elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI). However, the efficacy and safety of P2Y12 inhibitors pretreatment remain unclear.ObjectivesWe conducted a meta‐analysis to investigate the impact of P2Y12 inhibitor pretreatment on thrombotic and hemorrhagic endpoints in STEMI patients.MethodsWe searched multiple databases for studies that compared P2Y12 inhibitor pretreatment with no pretreatment in STEMI patients and reported endpoints of interest. Random effects model was used for the meta‐analysis.ResultsOur meta‐analysis included 3 randomized controlled trials and 14 observational studies, comprising 70,465 patients assigned to either P2Y12 inhibitor pretreatment (50,328 patients) or no pretreatment (20,137 patients). Compared to no pretreatment, P2Y12 inhibitor pretreatment did not result in significant reductions in all‐cause mortality (risk ratio [RR] 0.73; 95% confidence interval [CI]: 0.52–1.03; p = 0.07), myocardial infarction (RR 0.75; 95% CI: 0.53–1.07; p = 0.11), or major bleeding (RR 0.80; 95% CI: 0.56–1.16; p = 0.22) at 30 days. However, our subgroup analysis revealed that P2Y12 inhibitor pretreatment administered in the pre‐hospital setting was associated with a significant reduction in the incidence of myocardial infarction compared to no pretreatment (RR 0.73; 95% CI: 0.56–0.91; p < 0.01).ConclusionOur analysis suggests that pretreatment with oral P2Y12 inhibitors before PCI in patients with STEMI was not associated with reduced all‐cause mortality, myocardial infarction, or major bleeding. However, pretreatment with P2Y12 inhibitors in the pre‐hospital setting appears to be beneficial in reducing reinfarction.
Evaluation of physicochemical and sensorial properties of gluten‐free boza formulated with chia and quinoa flours
Authors: Göncü Ali , Kuzumoğlu Yasemin , Vardin Aslı Y. , Çelik İlyas , Karaman Ayşe D. 
Published: June 2023

AbstractBackground and objectivesBoza is a traditional cereal‐based (millet, corn, rice, etc.) and fermented beverage with sweet‐sour and bread‐like taste. It is a low‐alcohol and high‐viscosity beverage. In this study, it was aimed to develop a new gluten‐free boza formulation consisting of chia (100%), quinoa (100%) and chia + quinoa mixtures (50% + 50%) and determine its characteristics. For this purpose, physical, chemical, rheological, microbiological, and sensory properties of gluten‐free boza were researched.FindingsThe highest protein (6.44%), ash (0.89%), pH (3.24%), oil (0.84%), and mineral content were determined for the chia boza samples. The highest lightness (L*) and yellowness (+b*) values were determined in quinoa boza samples (p < .05). The highest soluble dietary fiber (1.22%) and insoluble dietary fiber (1.25%) contents were determined for chia boza samples. The dietary fiber content of quinoa and chia + quinoa boza were similar (p > .05). The highest lactic acid bacteria (9.03 lab log cfu/g) and yeast mould counts (6.72) were observed for quinoa boza samples. Rheological analyses results showed that all boza samples showed pseudoplastic behavior with a flow behavior index ranging from 0.66 to 0.98. The highest viscosity belonged to chia‐containing samples.ConclusionsConsidering sensory analyses, quinoa boza samples got the highest general acceptance in terms of color, sensory, flavor, and consistency according to panelists results.Significance and noveltyGluten‐free boza production with high nutritional value and acceptable taste can be achieved. For the first time, chia and quinoa were used as raw materials in the production of boza.
Traumatic myositis ossificans of the temporal muscle after dental local anesthesia
Authors: Helland Saeedeh Bagheri , Pedersen Torbjørn Østvik 
Published: June 2023

Key Clinical MessageTraumatic myositis ossificans of the temporal muscle can occur following local trauma. The diagnosis could be considered for patients presenting with therapy‐resistant trismus after intraoral procedures.AbstractA female in her 30s developed ossification of the temporal muscle attachment after local trauma during dental treatment, resulting in an inability to open her mouth. Following surgical treatment and physical therapy acceptable mouth opening and masticatory function was achieved.
Highly Efficient Oxindole‐Based Molecular Photoswitches
Authors: Doellerer Daniel , Pooler Daisy R. S. , Guinart Ainoa , Crespi Stefano , Feringa Ben L. 
Published: June 2023

Abstract3‐Benzylidene‐indoline‐2‐ones play a prominent role in the pharmaceutical industry due to the diverse biomedical applications of oxindole heterocycles. Despite the extensive reports on their biological properties, these compounds have hardly been studied for their photochemical activity. Here, we present 3‐benzylidene‐indoline‐2‐ones as a promising class of photoswitches with high yields, robust photochemical switching with quantum yields reaching up to 50 % and potential for biological applications.
Insights into the origins of inverted circular dichroism in thin films of a chiral side chain polyfluorene
Authors: Minion Louis , Wade Jessica , Moreno‐Naranjo Juan Manuel , Ryan Seán , Siligardi Giuliano , Fuchter Matthew J. 
Published: June 2023

AbstractWe synthesized a fluorene‐bithiophene co‐polymer with chiral side chains (cPFT2) and investigated its chiroptical properties via synchotronradiation circular dichroism. We observed that thin films of the polymer display an intense circular dichroism (CD) upon annealing, which is of opposite handedness to the CD reported for similar polyfluorenes bearing the same enantiomeric chiral side chain. We then contrast the properties of this polymer with chiral side chain fluorene homopolymer (cPF) and observe large differences in their thin film morphology. Using photoluminescence spectroscopy, we uncover evidence of polymer chain bending in cPFT2, which is further supported by theoretical calculations, and propose an explanation for the observed inverted optical activity.
A review of treatment options in HER2‐low breast cancer and proposed treatment sequencing algorithm
Authors: Roy Arya Mariam , Kumarasamy Vasanthan Muthusamy , Dhakal Ajay , O’Regan Ruth , Gandhi Shipra 
Published: June 2023

AbstractThe expansion of the spectrum of human epidermal growth factor receptor 2 (HER2)‐status to HER2‐low, defined as HER2 expression of 1+ by immunohistochemistry (IHC) or 2+ by IHC without gene amplification, has made a major impact in the field of oncology. The HER2‐low expression has emerged as a targetable biomarker, and anti‐HER2 antibody‐drug conjugate trastuzumab deruxtecan has shown significant survival benefit in pretreated metastatic HER2‐low breast cancer (BC). With these recent data, the treatment algorithm for hormone receptor–positive and triple‐negative BC needs to be reconsidered, as approximately half of these BCs are HER2‐low. Although there are different therapeutic agents for hormone receptor–positive and hormone receptor–negative HER2‐low BCs, there is no consensus regarding the sequencing of these agents. In this article, the treatment options for HER2‐low BC are enumerated and a treatment sequencing algorithm based on the current clinical evidence proposed.
Realizing Influence of Supports in Aqueous‐Phase Hydrogenation of Furfural over Nickel Catalysts
Authors: Rajpurohit Anil Singh , Mohan Talla Venkata Rama , Jaccob Madhavan , Ramaswamy Krishnamurthy Konda , Viswanathan Balasubramanian 
Published: June 2023

AbstractThe catalytic activity of nickel nanoparticles (5% Ni w/w loading) dispersed on different metal oxide supports has been explored for the hydrogenation of furfural. Nickel, supported on reducible oxides (CeO2 and TiO2), displays higher (almost 100%) conversion compared to that on non‐reducible oxide supports (SiO2, Al2O3, Mg3AlOx). H2‐TPR and XPS analyses bring out the influence of metal‐support interaction during the reduction of nickel precursor and their electronic properties. The adsorption and activation of furfural on the catalyst has been studied using infrared spectra and DFT calculations. The reaction proceeds via both ring‐rearrangement and ring hydrogenation pathways, with furfuryl alcohol as the primary intermediate. At higher reaction temperature, reducible oxide supported catalysts, particularly titania, favours deep‐hydrogenated products and higher conversion than non‐reducible oxide supported catalysts. Among all the catalysts, nickel on titania displayed maximum conversion of furfural. TiO2 possessing higher acidity than ceria, favoured ring‐rearrangement of furfuryl alcohol to cyclopentanone at high temperatures, while the latter retarded reduction of cyclopentanone due to blockage of active‐sites by unreacted furfural and strongly adsorbing intermediates. The combined effects of the electronic‐state of supported metal and surface acidity of catalyst provide a new strategy to tune catalytic properties for selective transformation during hydrogenation of furfural.