bluuebunny/crossref_metadata_2025_split huggingface dataset:
PK/PD analysis of trazodone and gabapentin in neuropathic pain rodent models: Translational PK‐PD modeling from nonclinical to clinical development
Authors: Oggianu Laura , Garrone Beatrice , Fiorentini Francesco , Del Bene Francesca , Rosignoli Maria Teresa , Di Giorgio Francesco Paolo , Kaminski Rafal Marian 
Published: February 2023

AbstractA pharmacokinetic/pharmacodynamic (PK/PD) model was developed to describe the time course of writhings after intraperitoneal injection of acetic acid in mice. The model was applied to investigate the antinociceptive effect of trazodone and gabapentin alone and in combination. Writhings time course was described by a transit compartment model with the delay due to the transit of the acetic acid being represented by a chain of intermediate compartments. In the drug‐treated animals, the number of writhings decreases according to a k2 factor linking drug concentration and antinociceptive effect. Compounds' potency parameters were 10.9 and 0.0459 L/μmoles/min for trazodone and gabapentin, respectively, indicating a much higher in vivo potency of trazodone in the PD writhing test. The PK/PD parameters were used to simulate the expected writhing counts in mice at combined doses without efficacy alone, assuming pharmacological additivity. Simulation results indicated that, at low dose combinations, experimental data were mostly below the simulated writhings median, suggesting possible synergic effect. Such hypothesis was tested by adding the γ parameter in the PK/PD model to represent the deviation from the assumption of no‐interaction, leading to a reduction of the objective function compared to the additive model. On this basis, several simulations were performed to identify possible starting dose combinations of trazodone and gabapentin in humans, by selecting doses yielding systemic exposures close to those being synergic in the mouse. Simulations indicated that doses of 50–100 mg trazodone could enhance gabapentin antinociceptive effect in humans, supporting the development of a low dose combination for optimal analgesia treatment.
Are Christian politics possible? A Kierkegaardian perspective
Authors: Ahmedov* Igor 
Published: February 2023

AbstractThis paper provides a rereading of Søren Kierkegaard's attack upon Christendom in light of his theory of spheres of existence to examine whether Christian politics are possible after Kierkegaard. Talking of Christian politics makes sense only in the esthetic and the religious spheres of existence. However, Kierkegaard argues that politics worthy of the title Christian are impossible. Either such politics are simply Christendom far removed from New Testament Christianity, or Christian politics are faced with the paradox of existing before God and cannot proceed.
Type 1 diabetes incidence in Scotland between 2006 and 2019
Authors: Thomson India , Anderson Niall , Bath Louise , Kiff Sarah , Patterson Chris , Philip Sam , Waugh Norman , Wild Sarah H. ,   the Scottish Study Group for the Care of Diabetes in the Young and the Scottish Diabetes Research Network Epidemiology Group
Published: February 2023

AbstractAimsTo describe type 1 diabetes incidence in Scotland between 2006 and 2019.MethodsRepeated annual cross‐sectional studies of type 1 diabetes incidence were conducted. Incident cases were identified from the Scottish Care Information—Diabetes Collaboration (SCI‐DC), a population‐based register of people with diagnosed diabetes derived from primary and secondary care data. Mid‐year population estimates for Scotland were used as the denominator to calculate annual incidence with stratification by age and sex. Joinpoint regression was used to investigate whether incidence changed during the study period. Age and sex‐specific type 1 diabetes incidence over the whole time period was estimated by quintile of the Scottish Index of Multiple Deprivation (SIMD), an area‐based measure, in which Q1 and Q5 denote the most and least deprived fifths of the population, respectively, with quasi‐Poisson regression used to compare incidence for Q5 compared to Q1.ResultsThe median (IQR) age of the study population of 14,564 individuals with incident type 1 diabetes was 24.1 (12.3–42.4) years, 56% were men, 23% were in Q1 and 16% were in Q5. Incidence of T1DM was higher in men than women overall (at around 22 and 17 per 100,000, respectively) and in under 15 year olds (approximately 40 per 100,000 in both sexes) than other age groups and was similar across the study period in all strata. There was an inverse association between socio‐economic status and type 1 diabetes incidence for 15–29, 30–49 and 50+ year olds [incidence rate ratio (IRR) for Q5 compared to Q1; IRR (95% CI) 0.52 (0.47–0.58), 0.68 (0.61–0.76) and 0.53(0.46–0.61), respectively] but not for under 15 year olds [1.02 (0.92–1.12)].ConclusionIncidence of type 1 diabetes varies by age, sex and socio‐economic status and has remained approximately stable from 2006 to 2019 in Scotland.
Liraglutide changes postprandial responses of gut hormones involved in the regulation of gallbladder motility
Authors: Nerild Henriette H. , Brønden Andreas , Gether Ida M. , Hellmann Pernille H. , Baekdal Mille , Gillum Matthew P. , Svenningsen Jens S. , Hartmann Bolette , Rathor Naveen , Kudiyanur Muniraju Hanna Angelene , Rehfeld Jens F. , Holst Jens J. , Vilsbøll Tina , Sonne David P. , Knop Filip K. 
Published: February 2023

AbstractAimLiraglutide treatment is associated with gallbladder‐related disorders and has been shown to delay postprandial gallbladder refilling. The gut hormones cholecystokinin (CCK), fibroblast growth factor 19 (FGF19) and glucagon‐like peptide 2 (GLP‐2), are known to regulate gallbladder motility and may be implicated in gallbladder‐related disorders associated with liraglutide treatment.Materials and MethodsIn a double‐blind, 12‐week trial, 52 participants [50% male, age 47.6 ± 10.0 years, body mass index 32.6 ± 3.4 kg/m2 (mean ± standard deviation)] with obesity were randomized 1:1 to once‐daily subcutaneous liraglutide (escalated from 0.6 mg to 3.0 mg once‐daily) or placebo. During liquid meal tests performed at baseline, after the first dose and following 12 weeks of treatment, we evaluated postprandial gallbladder dynamics and plasma responses of CCK, FGF19 and GLP‐2.ResultsLiraglutide reduced postprandial FGF19 after the first dose [area under the curve (AUC)0‐240 min 24.8 vs. 48.0 min × ng/ml, treatment ratio (TR) (95% confidence interval) 0.52 (0.39; 0.69)] and following 12 weeks of treatment [AUC0‐240 min 33.7 vs. 48.5 ng/ml × min, TR 0.69 (0.52; 0.93)]. Liraglutide also reduced postprandial GLP‐2 responses (AUC0‐240 min 3650 vs. 4894 min × pmol/L, TR 0.75 (0.62; 0.90)] following the first dose as well as after 12 weeks [AUC0‐240 min 3760 vs. 4882 min × pmol/L, TR 0.77 (0.60; 0.99)]. Liraglutide increased postprandial responses of CCK after the first dose [AUC0‐240 min 762 vs. 670 min × pmol/L; TR 1.14 (0.97; 1.33)] and following 12 weeks of treatment [AUC0‐240 min 873 vs. 628 min × pmol/L; TR 1.39 (1.12; 1.73)].ConclusionCompared with placebo, treatment with liraglutide decreased postprandial FGF19 and GLP‐2 concentrations and increased postprandial CCK concentrations, which may explain the delayed postprandial gallbladder refilling observed in individuals with obesity treated with liraglutide.
A micro perspective on r > g
Authors: Iacono Roberto , Palagi Elisa 
Published: February 2023

AbstractBy exploiting large‐scale administrative data on income and estimated personal wealth in Norway from 2010 to 2018, this paper establishes the first micro‐level analysis of the difference between the real return on wealth and the real growth rate of total pre‐tax income, across the entire net wealth distribution. We show that for the top 40% of the distribution, the aggregate of 1.8% underestimates its micro counterpart , while the opposite happens for the bottom 60%. Moreover, for the bottom 50% of the net wealth distribution, it is indeed the case that . In addition, we run a simulation exercise demonstrating that the full distribution of —which has been shown to be positively associated with the position in the net wealth distribution—delivers a higher predictive power for the study of wealth inequality than simply focusing on the aggregate . All results are robust to the exclusion of imputed rents from the income definition.
To Score or Not to Score: Factors Influencing Performance and Feasibility of Automatic Content Scoring of Text Responses
Authors: Zesch Torsten , Horbach Andrea , Zehner Fabian 
Published: February 2023

AbstractIn this article, we systematize the factors influencing performance and feasibility of automatic content scoring methods for short text responses. We argue that performance (i.e., how well an automatic system agrees with human judgments) mainly depends on the linguistic variance seen in the responses and that this variance is indirectly influenced by other factors such as target population or input modality. Extending previous work, we distinguish conceptual, realization, and nonconformity variance, which are differentially impacted by the various factors. While conceptual variance relates to different concepts embedded in the text responses, realization variance refers to their diverse manifestation through natural language. Nonconformity variance is added by aberrant response behavior. Furthermore, besides its performance, the feasibility of using an automatic scoring system depends on external factors, such as ethical or computational constraints, which influence whether a system with a given performance is accepted by stakeholders. Our work provides (i) a framework for assessment practitioners to decide a priori whether automatic content scoring can be successfully applied in a given setup as well as (ii) new empirical findings and the integration of empirical findings from the literature on factors that influence automatic systems' performance.
Couple relational ethics: From theory to lived practice
Authors: Fishbane Mona DeKoven 
Published: February 2023

AbstractDistressed couples often become polarized and caught up in power struggles, with competing claims and perspectives. When escalated, partners may become reactive and unkind. The competitive‐individualistic worldview of the Euro‐American culture feeds polarization between partners. This article explores relational views of the self and relational ethics developed in philosophy, psychology, feminist theory, neurobiology, and couple and family therapy that counter this individualistic view. A major focus is on the ways in which partners impact each other's identity and well‐being for better or worse, and the ethical responsibility this entails. The discussion addresses couple relational ethics within the larger sociocultural context that privileges power and competition. The paper offers applications to couple relationships and couple therapy, with interventions to promote mutual responsibility, fairness, dialogue, and care—helping partners to identify their higher values and interact with greater intentionality. A case example is offered to illustrate therapeutic techniques to enhance relational ethics in couples.
Biodiversity finance: A call for research into financing nature
Authors: Karolyi G. Andrew , Tobin‐de la Puente John 
Published: February 2023

AbstractBiodiversity conservation will supersede climate change risk mitigation and adaptation as the next grand challenge for sustainable finance. Closing the financing gap between what is currently spent and what is needed to be spent over the next 10 years to mobilize private investment to maintain ecosystem integrity and biodiversity, and the services they provide, is estimated to exceed hundreds of billions per year. Yet there are no studies in the top tier journals in finance that have framed the risks related to biodiversity loss, how those risks might be priced, or how the private financing flows need to be intermediated. We lay out one framework and outline important open research questions for financial economists to pursue.
Day‐night variation of microbial organic matter use in sediments of a saline shallow lake
Authors: Boadella Judit , Rodríguez‐Baliu Clara , Butturini Andrea , Romaní Anna M. 
Published: February 2023

Abstract

Knowledge of microbial functioning linked to dissolved organic matter (DOM) in hypersaline lakes is limited. This study aimed to understand this relationship in surface and subsurface sediments and how it is affected by daytime and night‐time variability.

A sampling regime, including daytime and night‐time measurements, was designed to record aerobic respiration, extracellular enzyme activity (β‐glucosidase, leu‐aminopeptidase and phosphatase), prokaryotic cell density and viability, content of pigment and extracellular polymeric substances (EPS), and organic matter weight in the surface and subsurface sediments. The main physicochemical characteristics and optical properties of DOM in the surface and interstitial waters were determined.

Larger differences were detected in biofilm microbial activity between surface and subsurface sediments than between day and night, as a result of higher prokaryotic cell density and higher availability of fresh DOM at the surface, possibly released from primary production. Redox conditions, pH and DOM quantity and quality were strongly correlated with enzyme activity and variability in respiration, and might determine (through modifying nitrogen (N) and phosphorus (P) availability) how microbes use organic compounds differently at the two sediment depths.

Low prokaryotic viability indicated that the microbial community was stressed in both surface and subsurface sediments. By contrast, higher EPS and pigment content and lower metabolic efficiency at the surface layer indicated harsher conditions compared to the subsurface layer. Pigment presence and variation in daily oxygen levels in the subsurface layer indicate that the two sediment depths are interconnected.

Results suggest that surface and subsurface microbes have a distinct role in hypersaline shallow lake sediment. Microorganisms in surface sediments form a structured mat with high EPS and carotenoids and enhanced carbon metabolism. The mat also serves as a protection shield from light radiation, salinity and desiccation. At the subsurface, the lower availability of fresh organic compounds and oxygen reduces microbial biomass and activity which is, in turn, more efficient and focused on N and P acquisition.
Mulching time of forest meadows influences insect diversity
Authors: Georgi Maria M. , Gärtner Stefanie M. , Förschler Marc I. , Buse Jörn , Fornoff Felix , Ssymank Axel , Oelmann Yvonne , Klein Alexandra‐Maria 
Published: February 2023

Abstract
The diversity in meadows is affected by numerous aspects, such as the amount and type of fertilisation and the timing and frequency of cutting. The effects of mowing on the diversity of plants and insects have been studied in detail. However, the effect of mulching (vegetation is cut, shredded, and left in place, instead of being removed) on insects in small forest meadows has received limited scrutiny to date.
In this study, we examined how different mulching times influenced insect diversity of forest meadows. We sampled insect larvae and observed flower‐visiting insects at 24 sites in the Northern Black Forest in south‐west Germany. We applied four treatments with six replicates each: (i) mulching in June, (ii) mulching in September, (iii) mulching in June and September, and (iv) no mulching as a control.
The overall larval community was dominated by Symphyta (45%, Hymenoptera) and Lepidoptera (44%). The flower‐visiting insect community was dominated by Syrphidae (80%, Diptera).
The insect larvae were negatively influenced by all mulching treatments. The abundance and species richness of flower visitors was reduced by mulching in June only and by mulching in both June and September.
Summary: Given that meadow management is required for conserving grassland diversity our results indicate that for insect larvae other mulching methods, than those we tested, such as mulching with an arthropod‐friendly mulching machine, strip‐mulching, or delayed mulching may help this crucial stage of insect development. For insect flower visitors mulching in September is beneficial.
A journey into the new employment service landscape of responsibilisation: Towards de‐personalisation of the caseworker–jobseeker relationship
Authors: Bengtsson Mattias , Jacobsson Kerstin , Wallinder Ylva 
Published: February 2023

AbstractThe article analyses a new culture of responsibilisation implicated in a recent management reform in the Swedish Public Employment Service. Based on an interview study and organisational documents, it is shown that the reform entails a new form of responsibilisation of jobseekers as well as caseworkers. As jobseekers are expected to ‘carry their own case’ through the administrative job‐search process, they are obliged to manage tasks that used to be in the caseworker's area of responsibility. Furthermore, caseworkers are expected to regulate themselves in new ways and change their mind‐set according to new organisational values and behavioural norms, requiring a restraining of their availability to clients. It is argued that the employment agency is increasingly turned into the agency of the active and responsible jobseeker, which entails one further shift towards individual responsibility in Swedish labour market policy and one further step towards the breakup of a personal caseworker–jobseeker relationship.
Teaching prototypes and pedagogical strategies in integrating Open Sim‐based virtual worlds in K‐12: Insights from perspectives and practices of teachers and students
Authors: Porat Erez , Shamir‐Inbal Tamar , Blau Ina 
Published: February 2023

AbstractIntroductionVirtual worlds (VWs) are immersive three‐dimensional environments, accessible simultaneously to multiple users, and described as shared, simulated spaces, whose inhabitants represented as avatars. VWs enable freedom of expression. Using VWs in educational contexts requires a shift from teacher‐centered instruction to facilitation of student‐centered learning practices.MethodThis study explores the degree of teacher centrality (Sage‐on‐the‐stage, Facilitator, Guide‐on‐the‐side, or Partner), pedagogical strategies used in the integration of an Open Sim‐based VW learning platform in face‐to‐face K‐12 classrooms, and consistency between the perspectives of teachers and students on these topics. We conducted semi‐structured interviews followed by observations of actual VW environments with 12 elementary teachers of different subject‐matters and 11 fifth and sixth graders who learn with VWs.FindingsAlthough all teaching prototypes were present in the data, the most dominant teaching prototypes in the VW environment were ‘Guide‐on‐the‐side’ and ‘Facilitator’, while ‘Sage‐on‐the‐stage’ and ‘Partner’ were less frequent. The findings indicate that the most prevalent pedagogical strategies used to teach in VW‐enhanced classrooms were Experiential Learning, followed by Training practice and modeling, Project‐based learning, Game‐based learning, and Collaborative learning. Minor differences were found between the perspectives of teachers and students regarding teaching prototypes and the degree of teacher centrality in the classroom. Importantly, both teachers and students positioned students as the main designers of learning activities in the VW environment.ImplicationsThe findings of this pioneer research provide insights regarding the teaching prototypes and the degree of teacher centrality in the VW learning environment that can help improve teaching processes and professional training courses in virtual 3D environments.
Moving lab‐based in‐person training to online delivery: The case of a continuing engineering education program
Authors: Maware Catherine , Parsley David M. , Huang Kun , Swan Gerry M. , Akafuah Nelson 
Published: February 2023

AbstractBackgroundOnline learning has recently surged due to the COVID‐19 global pandemic. Because of the pandemic, many universities were forced to move to online learning, and various online teaching and learning environments emerged, both asynchronous and synchronous.ObjectiveThis study explores how a large university in the Southeastern United States of America converted an in‐person Lean Manufacturing professional course into synchronous online learning for industry participants.MethodThe study analysed the performance of 212 in‐person and 43 online industry participants and examined the views of online participants about the training. Paired t‐tests, one‐way multivariate analysis of covariance (MANCOVA), and univariate analysis of covariance (ANCOVA) were utilized to evaluate the performance of the in‐person and online groups on the three competencies (Lean culture, problem‐solving and Lean systems).Results and ConclusionBoth online and in‐person programs performed equally well in two Lean Manufacturing competencies: Lean systems and problem solving. The online program outperformed the in‐person program in the third competency, Lean culture. Overall, the participants had a positive experience with the structure and organization of the online program, and their impression of the online learning environment for the program was positive. The study findings indicated that Lean Manufacturing could be trained effectively online and in person. Best practices are suggested for the conversion of in‐person to synchronous online engineering continuing education programs.
Leveraging natural language processing to support automated assessment and feedback for student open responses in mathematics
Authors: Botelho Anthony , Baral Sami , Erickson John A. , Benachamardi Priyanka , Heffernan Neil T. 
Published: February 2023

AbstractBackgroundTeachers often rely on the use of open‐ended questions to assess students' conceptual understanding of assigned content. Particularly in the context of mathematics; teachers use these types of questions to gain insight into the processes and strategies adopted by students in solving mathematical problems beyond what is possible through more close‐ended problem types. While these types of problems are valuable to teachers, the variation in student responses to these questions makes it difficult, and time‐consuming, to evaluate and provide directed feedback. It is a well‐studied concept that feedback, both in terms of a numeric score but more importantly in the form of teacher‐authored comments, can help guide students as to how to improve, leading to increased learning. It is for this reason that teachers need better support not only for assessing students' work but also in providing meaningful and directed feedback to students.ObjectivesIn this paper, we seek to develop, evaluate, and examine machine learning models that support automated open response assessment and feedback.MethodsWe build upon the prior research in the automatic assessment of student responses to open‐ended problems and introduce a novel approach that leverages student log data combined with machine learning and natural language processing methods. Utilizing sentence‐level semantic representations of student responses to open‐ended questions, we propose a collaborative filtering‐based approach to both predict student scores as well as recommend appropriate feedback messages for teachers to send to their students.Results and ConclusionWe find that our method outperforms previously published benchmarks across three different metrics for the task of predicting student performance. Through an error analysis, we identify several areas where future works may be able to improve upon our approach.