bluuebunny/crossref_metadata_2025_split huggingface dataset:
Representing Bidirectional Hydraulic Continuum Between the Stream and Hillslope in the National Water Model for Improved Streamflow Prediction
Authors: Hong M. , Mohanty B. P. 
Published: March 2023

AbstractAlthough hydraulic groundwater (GW) theory has been recognized as a promising tool for understanding the role of the aquifer(s) in the surface‐subsurface hydrologic cycle, the integrated modeling community still lacks a proper hydrologic structure to apply the well‐studied theory to large‐scale hydrologic predictions. This study aims to present a novel hydrologic structure that enables the Boussinesq equation‐based depiction of the bidirectional stream‐hillslope processes for applying hydraulic GW theory to large‐scale model configurations. We integrated the BE3S's (Hong et al., 2020, https://doi.org/10.1029/2020wr027571) representation scheme of the catchment‐scale stream‐hillslope continuum into the National Water Model (NWM) and applied the modified NWM (i.e., the NWM‐BE3S) to three major basins in Texas (i.e., the Trinity, Brazos, and Colorado River basins). Since the NWM currently relies on a single reservoir model for baseflow simulation, we used the Boussinesq aquifer as an alternative subsurface hydrology routine and evaluated its predictive skill and efficacy. We identified that the implemented Boussinesq aquifer(s) in the NWM‐BE3S yielded noticeable improvements in predicting streamflow for aquifers that exhibited higher nonlinearities in the observed recessions. The varying degree of improvements in streamflow predictions per the recession nonlinearities demonstrated not only (a) the algorithmic enhancement of subsurface hydrology (physics) but also (b) the applicability of the Boussinesq theory‐based depiction of the stream‐hillslope two‐way continuum. We diagnosed each stream's state based on the bidirectional stream‐hillslope exchanges and identified the dominant processes (i.e., river infiltration or baseflow) that were represented spatially in the NWM‐BE3S.
Failing Subduction Initiation in an Opposing Pair of Incipient‐Diffuse Subduction Margins: A Case From the East Sea (Japan Sea)
Authors: Lee Jae‐Hyuk , Yoon Seok‐Hoon , Kim Yoon‐Mi , So Byung‐Dal , Kim Gi‐Bom 
Published: March 2023

AbstractThis study reports a rare case of failing incipient subduction found in the East Sea (Japan Sea), a back‐arc basin in the western circum‐Pacific, where an opposing pair of incipient‐diffuse subduction margins competes to attain self‐sustainability. Seismic reflection analysis of the post‐4 Ma structural components around the western East Sea margin revealed three juxtaposed compressional neotectonic components: (a) the Ulleung Major Thrust, (b) the Ulleung Syncline, and (c) the East Korean Thrust Belt. The Ulleung Major Thrust, marked by the NS‐elongated west‐dipping reverse tri‐shear zone along the continent–back‐arc transition boundary, is interpreted as an embryonic subduction interface that began to guide the underthrust of the Ulleung back‐arc crust below the Korean continental block. With the growth of the Ulleung Major Thrust, the crustal downbuckle on the western end of the Ulleung Basin became progressively asymmetric and formed the Ulleung Syncline, a proto‐trench. Underthrusting of the Ulleung Basin crust induced regional uplift over the eastern Korean margin, accommodated by arrays of east‐dipping thrust faults referred to as the East Korean Thrust Belt. The east‐upward thrust movements formed NS‐elongated thrust‐bounded sedimentary basins, classified as piggyback basins. The subduction initiation on the western East Sea margin appears destined to fail, because a convergent proto‐plate boundary is now nucleating on its opposing side. However, lines of evidence, such as marine terraces and frequent compressional earthquakes on Quaternary faults along the eastern Korean margin imply that the subduction initiation on the western East Sea is failing but has not yet failed.
Practice harmonization workshops of EBMT: an expert-based approach to generate practical and contemporary guidelines within the arena of hematopoietic cell transplantation and cellular therapy
Authors: Yakoub-Agha Ibrahim , Greco Raffaella , Onida Francesco , de la Cámara Rafael , Ciceri Fabio , Corbacioglu Selim , Dolstra Harry , Glass Bertram , Kenyon Michelle , McLornan Donal P. , Neven Bénédicte , de Latour Regis Peffault , Peric Zinaida , Ruggeri Annalisa , Snowden John A. , Sureda Anna , Sánchez-Ortega Isabel 
Published: March 2023

AbstractFor hematopoietic cell transplantation (HCT) and cellular therapy (CT), clinical patient care is localized, and practices may differ between countries and from center to center even within the same country. Historically, international guidelines were not always adapted to the changing daily clinical practice and practical topics there were not always addressed. In the absence of well-established guidelines, centers tended to develop local procedures/policies, frequently with limited communication with other centers. To try to harmonize localized clinical practices for malignant and non-malignant hematological disorders within EBMT scope, the practice harmonization and guidelines (PH&G) committee of the EBMT will co-ordinate workshops with topic-specific experts from interested centers. Each workshop will discuss a specific issue and write guidelines/recommendations that practically addresses the topic under review. To provide clear, practical and user-friendly guidelines when international consensus is lacking, the EBMT PH&G committee plans to develop European guidelines by HCT and CT physicians for peers’ use. Here, we define how workshops will be conducted and guidelines/recommendations produced, approved and published. Ultimately, there is an aspiration for some topics, where there is sufficient evidence base to be considered for systematic reviews, which are a more robust and future-proofed basis for guidelines/recommendations than consensus opinion.
Detection of circulating cell-free HPV DNA of 13 HPV types for patients with cervical cancer as potential biomarker to monitor therapy response and to detect relapse
Authors: Mittelstadt Suzana , Kelemen Olga , Admard Jakob , Gschwind Axel , Koch André , Wörz Sarah , Oberlechner Ernst , Engler Tobias , Bonzheim Irina , Staebler Annette , Weidner Nicola , Stubenrauch Frank , Iftner Thomas , Riess Olaf , Schroeder Christopher , Kommoss Stefan , Ossowski Stephan 
Published: March 2023

Abstract
Background
HPV-related cervical cancer (CC) is the fourth most frequent cancer in women worldwide. Cell-free tumour DNA is a potent biomarker to detect treatment response, residual disease, and relapse. We investigated the potential use of cell-free circulating HPV-DNA (cfHPV-DNA) in plasma of patients with CC.

Methods
cfHPV-DNA levels were measured using a highly sensitive next-generation sequencing-based approach targeting a panel of 13 high-risk HPV types.

Results
Sequencing was performed in 69 blood samples collected from 35 patients, of which 26 were treatment-naive when the first liquid biopsy sample was retrieved. cfHPV-DNA was successfully detected in 22/26 (85%) cases. A significant correlation between tumour burden and cfHPV-DNA levels was observed: cfHPV-DNA was detectable in all treatment-naive patients with advanced-stage disease (17/17, FIGO IB3–IVB) and in 5/9 patients with early-stage disease (FIGO IA–IB2). Sequential samples revealed a decrease of cfHPV-DNA levels in 7 patients corresponding treatment response and an increase in a patient with relapse.

Conclusions
In this proof-of-concept study we demonstrated the potential of cfHPV-DNA as a biomarker for therapy monitoring in patients with primary and recurrent CC. Our findings facilitate the development of a sensitive and precise, non-invasive, inexpensive, and easily accessible tool in CC diagnosis, therapy monitoring and follow-up.
Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome
Authors: Körber Verena , Stainczyk Sabine A. , Kurilov Roma , Henrich Kai-Oliver , Hero Barbara , Brors Benedikt , Westermann Frank , Höfer Thomas 
Published: March 2023

AbstractNeuroblastoma, the most frequent solid tumor in infants, shows very diverse outcomes from spontaneous regression to fatal disease. When these different tumors originate and how they evolve are not known. Here we quantify the somatic evolution of neuroblastoma by deep whole-genome sequencing, molecular clock analysis and population-genetic modeling in a comprehensive cohort covering all subtypes. We find that tumors across the entire clinical spectrum begin to develop via aberrant mitoses as early as the first trimester of pregnancy. Neuroblastomas with favorable prognosis expand clonally after short evolution, whereas aggressive neuroblastomas show prolonged evolution during which they acquire telomere maintenance mechanisms. The initial aneuploidization events condition subsequent evolution, with aggressive neuroblastoma exhibiting early genomic instability. We find in the discovery cohort (n = 100), and validate in an independent cohort (n = 86), that the duration of evolution is an accurate predictor of outcome. Thus, insight into neuroblastoma evolution may prospectively guide treatment decisions.
Visible-light induced degradation of diphenyl urea and polyethylene using polythiophene decorated CuFe2O4 nanohybrids
Authors: Riaz Ufana , Gaffar Shayista , Hauser Kristen , Yan Fei 
Published: March 2023

AbstractThe present work reports facile synthesis of CuFe2O4 nanoparticles via co-precipitation method and formulation of its nanohybrids with polythiophene (PTh). The structural and morphological properties were investigated using fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy coupled with energy dispersive spectra (SEM-EDS) and UV–Vis spectroscopy. The band gap was found to decrease with increase in the loading of PTh and was found to be 2.52 eV for 1-PTh/CuFe2O4, 2.15 eV for 3-PTh/CuFe2O4 and 1.89 eV for 5-PTh/CuFe2O4. The nanohybrids were utilized as photocatalysts for visible light induced degradation of diphenyl urea. Diphenyl urea showed 65% degradation using 150 mg catalyst within 120 min. Polyethylene (PE) was also degraded using these nanohybrids under visible light as well as microwave irradiation to compare its catalytic efficiency under both conditions. Almost 50% of PE was degraded under microwave and 22% under visible light irradiation using 5-PTh/CuFe2O4. The degraded diphenyl urea fragments were analyzed using LCMS and a tentative mechanism of degradation was proposed.
Biomechanical stability of hernia-damaged abdominal walls
Authors: Karrech Ali , Ahmad Hairul , Hamdorf Jeffrey M 
Published: March 2023

AbstractHernia occurs when the peritoneum and/or internal organs penetrate through a defect in the abdominal wall. Implanting mesh fabrics is a common way to reinforce the repair of hernia-damaged tissues, despite the risks of infection and failure associated with them. However, there is neither consensus on the optimum mesh placement within the abdominal muscles complex nor on the minimum size of hernia defect that requires surgical correction. Here we show that the optimum position of the mesh depends on the hernia location; placing the mesh on the transversus abdominis muscles reduces the equivalent stresses in the damaged zone and represents the optimum reinforcement solution for incisional hernia. However, retrorectus reinforcement of the linea alba is more effective than preperitoneal, anterectus, and onlay implantations in the case of paraumbilical hernia. Using the principles of fracture mechanics, we found that the critical size of a hernia damage zone becomes severe at 4.1 cm in the rectus abdominis and at larger sizes (5.2–8.2 cm) in other anterior abdominal muscles. Furthermore, we found that the hernia defect size must reach 7.8 mm in the rectus abdominis before it influences the failure stress. In other anterior abdominal muscles, hernia starts to influence the failure stress at sizes ranging from 1.5 to 3.4 mm. Our results provide objective criteria to decide when a hernia damage zone becomes severe and requires repair. They demonstrate where mesh should be implanted for a mechanically stable reinforcement, depending on the type of hernia. We anticipate our contribution to be a starting point for sophisticated models of damage and fracture biomechanics. For example, the apparent fracture toughness is an important physical property that should be determined for patients living with different obesity levels. Furthermore, relevant mechanical properties of abdominal muscles at various ages and health conditions would be significant to generate patient specific results.
Function predicts how people treat their dogs in a global sample
Authors: Chira Angela M. , Kirby Kathryn , Epperlein Theresa , Bräuer Juliane 
Published: March 2023

AbstractDogs have an extraordinary relationship with humans. We understand, communicate, and cooperate remarkably with our dogs. But almost all we know about dog-human bonds, dog behaviour, and dog cognition is limited to Western, Educated, Industrialized, Rich, Democratic (WEIRD) societies. WEIRD dogs are kept for a variety of functions, and these can influence their relationship with their owner, as well as their behaviour and performance in problem-solving tasks. But are such associations representative worldwide? Here we address this by collecting data on the function and perception of dogs in 124 globally distributed societies using the eHRAF cross-cultural database. We hypothesize that keeping dogs for multiple purposes and/or employing dogs for highly cooperative or high investment functions (e.g., herding, guarding of herds, hunting) will lead to closer dog-human bonds: increased primary caregiving (or positive care), decreased negative treatment, and attributing personhood to dogs. Our results show that indeed, the number of functions associates positively with close dog-human interactions. Further, we find increased odds of positive care in societies that use herding dogs (an effect not replicated for hunting), and increased odds of dog personhood in cultures that keep dogs for hunting. Unexpectedly, we see a substantial decrease of dog negative treatment in societies that use watchdogs. Overall, our study shows the mechanistic link between function and the characteristics of dog-human bonds in a global sample. These results are a first step towards challenging the notion that all dogs are the same, and open questions about how function and associated cultural correlates could fuel departures from the ‘typical’ behaviour and social-cognitive skills we commonly associate with our canine friends.
Emergence of an erythroid cell-specific regulatory region in ABO intron 1 attributable to A- or B-antigen expression on erythrocytes in Hominoidea
Authors: Sano Rie , Fukuda Haruki , Kubo Rieko , Oishi Takao , Miyabe-Nishiwaki Takako , Kaneko Akihisa , Masato Haruhisa , Takahashi Yoichiro , Hayakawa Akira , Yazawa Shin , Kominato Yoshihiko 
Published: March 2023

AbstractA- and B-antigens are present on red blood cells (RBCs) as well as other cells and secretions in Hominoidea including humans and apes such as chimpanzees and gibbons, whereas expression of these antigens on RBCs is subtle in monkeys such as Japanese macaques. Previous studies have indicated that H-antigen expression has not completely developed on RBCs in monkeys. Such antigen expression requires the presence of H-antigen and A- or B-transferase expression in cells of erythroid lineage, although whether or not ABO gene regulation is associated with the difference of A- or B-antigen expression between Hominoidea and monkeys has not been examined. Since it has been suggested that ABO expression on human erythrocytes is dependent upon an erythroid cell-specific regulatory region or the + 5.8-kb site in intron 1, we compared the sequences ofABOintron 1 among non-human primates, and demonstrated the presence of sites orthologous to the + 5.8-kb site in chimpanzees and gibbons, and their absence in Japanese macaques. In addition, luciferase assays revealed that the former orthologues enhanced promoter activity, whereas the corresponding site in the latter did not. These results suggested that the A- or B-antigens on RBCs might be ascribed to emergence of the + 5.8-kb site or the corresponding regions inABOthrough genetic evolution.
Effect of sclerostin inactivation in a mouse model of severe dominant osteogenesis imperfecta
Authors: Marulanda Juliana , Tauer Josephine T. , Boraschi-Diaz Iris , Bardai Ghalib , Rauch Frank 
Published: March 2023

AbstractOsteogenesis imperfecta (OI) is a rare bone disease that is associated with fractures and low bone mass. Sclerostin inhibition is being evaluated as a potential approach to increase bone mass in OI. We had previously found that in Col1a1Jrt/+ mice, a model of severe OI, treatment with an anti-sclerostin antibody had a minor effect on the skeletal phenotype. In the present study, we assessed the effect of genetic sclerostin inactivation in the Col1a1Jrt/+ mouse. We crossed Col1a1Jrt/+ mice with Sost knockout mice to generate Sost-deficient Col1a1Jrt/+ mice and assessed differences between Col1a1Jrt/+ mice with homozygous Sost deficiency and Col1a1Jrt/+ mice with heterozygous Sost deficiency. We found that Col1a1Jrt/+ mice with homozygous Sost deficiency had higher body mass, femur length, trabecular bone volume, cortical thickness and periosteal diameter as well as increased biomechanical parameters of bone strength. Differences between genotypes were larger at the age of 14 weeks than at 8 weeks of age. Transcriptome analysis of RNA extracted from the tibial diaphysis revealed only 5 differentially regulated genes. Thus, genetic inactivation of Sost increased bone mass and strength in the Col1a1Jrt/+ mouse. It appears from these observations that the degree of Sost suppression that is required for eliciting a beneficial response can vary with the genetic cause of OI.
Two-dimensional single crystal monoclinic gallium telluride on silicon substrate via transformation of epitaxial hexagonal phase
Authors: Zallo Eugenio , Pianetti Andrea , Prikhodko Alexander S. , Cecchi Stefano , Zaytseva Yuliya S. , Giuliani Alessandro , Kremser Malte , Borgardt Nikolai I. , Finley Jonathan J. , Arciprete Fabrizio , Palummo Maurizia , Pulci Olivia , Calarco Raffaella 
Published: March 2023

AbstractVan der Waals (vdW) epitaxial growth of large-area and stable two-dimensional (2D) materials of high structural quality on crystalline substrates is crucial for the development of novel device technologies. 2D gallium monochalcogenides with low in-plane symmetry stand out among the layered semiconductor materials family for next-generation optoelectronic and energy conversion applications. Here, we demonstrate the formation of large-area, single crystal and optically active 2D monoclinic gallium telluride (m-GaTe) on silicon substrate via rapid thermal annealing induced phase transformation of vdW epitaxial metastable hexagonal gallium telluride (h-GaTe). Stabilization of multilayer h-GaTe on Si occurs due to the role of the first layer symmetry together with efficient GaTe surface passivation. Moreover, we show that the phase transformation of h-GaTe to m-GaTe is accompanied by the strain relaxation between Si substrate and GaTe. This work opens the way to the fabrication of single-crystal 2D anisotropic semiconductors on standard crystalline wafers that are difficult to be obtained by epitaxial methods.
Membrane tension induces F-actin reorganization and flow in a biomimetic model cortex
Authors: Sakamoto Ryota , Banerjee Deb Sankar , Yadav Vikrant , Chen Sheng , Gardel Margaret L. , Sykes Cecile , Banerjee Shiladitya , Murrell Michael P. 
Published: March 2023

AbstractThe accumulation and transmission of mechanical stresses in the cell cortex and membrane determines the mechanics of cell shape and coordinates essential physical behaviors, from cell polarization to cell migration. However, the extent that the membrane and cytoskeleton each contribute to the transmission of mechanical stresses to coordinate diverse behaviors is unclear. Here, we reconstitute a minimal model of the actomyosin cortex within liposomes that adheres, spreads and ultimately ruptures on a surface. During spreading, accumulated adhesion-induced (passive) stresses within the membrane drive changes in the spatial assembly of actin. By contrast, during rupture, accumulated myosin-induced (active) stresses within the cortex determine the rate of pore opening. Thus, in the same system, devoid of biochemical regulation, the membrane and cortex can each play a passive or active role in the generation and transmission of mechanical stress, and their relative roles drive diverse biomimetic physical behaviors.
Dangerous Decibels Program in Elementary and Middle School Students: Effectiveness After a 6-Month Follow-Up
Authors: Gomes Raquel Fornaziero , Matas Carla Gentile , Samelli Alessandra Giannella 
Published: March 2023

Purpose:The purpose of this article was to assess the effectiveness of the Dangerous Decibels (DD) program in students in the short- and medium-term follow-ups (up to 6 months), including an online game.Method:A randomized trial was conducted between two interventions (DD and placebo). The research included 58 participants who were divided into two groups: the study group (SG) and the control group. The following phases were developed: intervention (DD or placebo), post–3-month assessment and availability of the online game, and post–6-month assessment. A questionnaire was administered to assess their performance. Overall total scores and category scores were obtained.Results:Improved overall scores were found in the SG in the immediate post-intervention (p= .004), post–3-month (p= .022), and post–6-month (p= .002) questionnaires, as well as the knowledge and behavior categories.Conclusions:The DD program effectively improved the knowledge and behavior of 10- to 12-year-old children regarding noise in the short- and medium-term follow-ups. However, no significant changes were achieved in terms of barriers only by using the program and the online game. Adding a second intervention (the online game) to the program seems to be a good option to maintain the changes achieved with the interactive class.
An expandable 36‐channel neural recording ASIC with modular digital pixel design technique
Authors: Wang Quan , Wang Gang , You Changhua , Zhang Xuan , Liu Daoyin , Zeng Huanhuan , Xue Ning , Yao Lei , Li Tie 
Published: March 2023

AbstractThis paper presents the design and implementation of an expandable neural recording ASIC for multiple‐channel neural recording applications. The ASIC consists of 36 modular digital pixels (MDPs) and a global digital controller (GDC) circuit. Each MDP has an analog frontend (AFE) circuit, a 12‐bit successive approximation register ADC (SAR ADC), and a local digital controller (LDC) circuit. It achieves 5.9‐μV input referred noise (IRN), 10.8‐effective number of bits (ENOB), 37.8‐μW power consumption, and 0.095 mm2 area per channel. The ASIC is implemented in commercial SMIC 0.18‐μm CMOS process and validated by in‐vivo experiment on a lab mouse with a 36‐channel silicon‐based neural probe.