bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nitrite accumulation and anammox bacterial niche partitioning in Arctic Mid-Ocean Ridge sediments
Authors: Zhao Rui , Babbin Andrew R , Roerdink Desiree L , Thorseth Ingunn H , Jørgensen Steffen L 
Published: March 2023

Abstract
By consuming ammonium and nitrite, anammox bacteria form an important functional guild in nitrogen cycling in many environments, including marine sediments. However, their distribution and impact on the important substrate nitrite has not been well characterized. Here we combined biogeochemical, microbiological, and genomic approaches to study anammox bacteria and other nitrogen cycling groups in two sediment cores retrieved from the Arctic Mid-Ocean Ridge (AMOR). We observed nitrite accumulation in these cores, a phenomenon also recorded at 28 other marine sediment sites and in analogous aquatic environments. The nitrite maximum coincides with reduced abundance of anammox bacteria. Anammox bacterial abundances were at least one order of magnitude higher than those of nitrite reducers and the anammox abundance maxima were detected in the layers above and below the nitrite maximum. Nitrite accumulation in the two AMOR cores co-occurs with a niche partitioning between two anammox bacterial families (Candidatus Bathyanammoxibiaceae and Candidatus Scalinduaceae), likely dependent on ammonium availability. Through reconstructing and comparing the dominant anammox genomes (Ca. Bathyanammoxibius amoris and Ca. Scalindua sediminis), we revealed that Ca. B. amoris has fewer high-affinity ammonium transporters than Ca. S. sediminis and lacks the capacity to access alternative substrates and/or energy sources such as urea and cyanate. These features may restrict Ca. Bathyanammoxibiaceae to conditions of higher ammonium concentrations. These findings improve our understanding about nitrogen cycling in marine sediments by revealing coincident nitrite accumulation and niche partitioning of anammox bacteria.
3D Video Tracking Technology in the Assessment of Orofacial Impairments in Neurological Disease: Clinical Validation
Authors: Jafari Deniz , Simmatis Leif , Guarin Diego , Bouvier Liziane , Taati Babak , Yunusova Yana 
Published: March 2023

Purpose:
This study sought to determine whether clinically interpretable kinematic features extracted automatically from three-dimensional (3D) videos were correlated with corresponding perceptual clinical orofacial ratings in individuals with orofacial impairments due to neurological disorders.

Method:

45 participants (19 diagnosed with motor neuron diseases [MNDs] and 26 poststroke) performed two nonspeech tasks (mouth opening and lip spreading) and one speech task (repetition of a sentence “Buy Bobby a Puppy”) while being video-recorded in a standardized lab setting. The color video recordings of participants were assessed by an expert clinician—a speech language pathologist—on the severity of three orofacial measures: symmetry, range of motion (ROM), and speed. Clinically interpretable 3D kinematic features, linked to symmetry, ROM, and speed, were automatically extracted from video recordings, using a deep facial landmark detection and tracking algorithm for each of the three tasks. Spearman correlations were used to identify features that were significantly correlated (
p
value < .05) with their corresponding clinical scores. Clinically significant kinematic features were then used in the subsequent multivariate regression models to predict the overall orofacial impairment severity score.

Results:
Several kinematic features extracted from 3D video recordings were associated with their corresponding perceptual clinical scores, indicating clinical validity of these automatically derived measures. Different patterns of significant features were observed between MND and poststroke groups; these differences were aligned with clinical expectations in both cases.

Conclusions:
The results show that kinematic features extracted automatically from simple clinical tasks can capture characteristics used by clinicians during assessments. These findings support the clinical validity of video-based automatic extraction of kinematic features.
The value of 2019 EULAR/ACR classification criteria in predicting lupus nephritis in childhood-onset systemic lupus erythematosus
Authors: Cetin Nuran , Acikalin Mustafa Fuat , Tufan Asli Kavaz , Kasifoglu Nilgun 
Published: March 2023

AbstractBackground We investigated the role of European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for the prediction of LN among children with SLE.Methods The data of the patients with childhood-onset SLE diagnosed based on 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria were retrospectively evaluated. Based on 2019 EULAR/ACR classification criteria, the scoring was done at the time of renal biopsy.Results Fifty-two patients (12 with LN, 40 without LN) were included. The mean score was higher in patients with LN than those without (30.8±6.14, 19.8±7.76, respectively, p=0.000). The score value had indicative value for LN (area under curve [AUC]:0.863±0.055, cut-off value:22.5, p=0.000). Lymphocyte counts had a predictive value for LN (cut-off value:905/mm3, AUC:0.688±0.087, p=0.042). The score was positively associated with SLE disease activity index (SLEDAI) and activity index (r=0.879, p=0.000; r=0.811, p=0.001, respectively). There were significant negative associations between score value and GFR (r=-0.582, p=0.047). The patients with renal flare had higher the mean score than those of without renal flare (35±2/25.4±5.57, respectively, p=0.019).Conclusions The EULAR/ACR criteria score could reflect the activity of disease and severity of nephritis in childhood-onset SLE. A point of 22.5 as score value might be an indicator for LN. During scoring, it should be taken into account that lymphopenia might guide the prediction of LN.
Kardiologische Rehabilitation als effektive Sekundärprävention
Authors: Schwaab Bernhard , Reibis Rona K. , Völler Heinz 
Published: March 2023

ZusammenfassungZiele der kardiologischen Rehabilitation (kurz: KardReha) sind die Wiederherstellung der individuell bestmöglichen physischen und psychischen Gesundheit kardiovaskulär erkrankter Patienten
durch die Therapie in einem multidisziplinären Team, diese nachhaltig zu stabilisieren und die berufliche und soziale Re-Integration zu ermöglichen. Auf der Basis einer S3-Leitlinie zur
KardReha im deutschsprachigen Raum Europas führt die Teilnahme an einer KardReha bei Patienten nach akutem Koronarsyndrom und nach Bypass-Operation zu einer signifikanten Reduktion der
Gesamtmortalität. Bei Patienten mit systolischer Herzinsuffizienz werden die körperliche Belastbarkeit und die Lebensqualität signifikant verbessert. Nach operativer oder interventioneller
Herzklappenkorrektur werden die körperliche Belastbarkeit sowie die Lebensqualität gesteigert, und in ersten Studien zeigen sich Signale für eine Mortalitätsreduktion. Daher sollte die
KardReha ein integraler Bestandteil einer am langfristigen Erfolg orientierten Behandlung sein.
Bolusobstruktionen im Ösophagus – Eine Analyse über 5 Jahre
Authors: Heise Jürgen , Kreysel Christian , Blank Michael , Euler Philipp , Melchior Ilka , Johnen Michaela , Planker Manfred , Ballauff Antje , Czypull Martina , Frieling Thomas 
Published: March 2023

Zusammenfassung
Hintergrund Die Entfernung einer Bolusobstruktion im Ösophagus ist eine Indikation zur Notfallendoskopie. In der aktuellen Leitlinie der European Society of Gastrointestinal Endoscopy (ESGE) wird u. a der Vorschub des Bolus in den Magen empfohlen, was von vielen Endoskopikern aufgrund der erhöhten Komplikationsgefahr kritisch gesehen wird. Auch wird die Endoskop-Aufsetzkappe als Möglichkeit der Bolusentfernung nicht aufgeführt.
Methode In einer retrospektiven Analyse wurden 66 Erwachsene und 11 Kinder mit einer akuten Bolusobstruktion im Ösophagus von 2017 bis 2021 retrospektiv analysiert.
Ergebnisse Eine eosinophile Ösophagitis, Refluxösophagitis / peptische Stenose bzw. Schatzki-Ringe waren für 57,6%, Ösophagus- bzw. Bronchialkarzinome für 18%, Ösophagusmotilitätsstörungen für 4,5%, ein Zenkerʼsches Divertikel bzw. eine Strahlenösophagitis für je 1,5% der Bolusobstruktionen verantwortlich. In 16,7% konnte keine Ursache gefunden werden. Bei den Kindern zeigte sich ein vergleichbares Spektrum, wobei in 2 Fällen eine Stenose bei Ösophagusatresie vorkam. In 2 Fällen konnte keine Ursache gefunden werden. Eine Bolusentfernung war bei Erwachsenen in 92,4% und bei Kindern in 100% der Fälle möglich. Der Bolusverschluss konnte bei Erwachsenen in 57,6% und bei Kindern in 75% ausschließlich mit der Endoskop-Aufsetzkappe sicher entfernt werden. In nur 9% der Fälle war es möglich, den Bolus ohne vorherige Desintegration unter Sicht kontrolliert in den Magen vorzuschieben.
Schlussfolgerung Die flexible Endoskopie ist eine effektive Notfallmaßnahme zur Bolusentfernung aus dem Ösophagus. Ein unkontrolliertes blindes Vorschieben des Bolus in den Magen kann nicht empfohlen werden. Die Endoskop-Aufsetzkappe ist eine sehr gute Ergänzung zur sicheren Bolusentfernung.
Does the Association of Hashimoto's Thyroiditis with
Differentiated Thyroid Cancer Really Have a Protective Role?
Authors: Demir Ahmet Numan , Kara Zehra , Sulu Cem , Uysal Serhat , Sahin Serdar , Zulfaliyeva Guldana , Atar Oznur Aydin , Valikhanova Nahida , Ozturk Tulin , Ozkaya Hande Mefkure , Gonen Mustafa Sait 
Published: March 2023

AbstractThe study is an investigation of aggressive tumor features, prognosis, and
disease-specific mortality rates of differentiated thyroid cancer (DTC) in the
presence of concomitant Hashimoto’s Thyroiditis (HT). The data of
patients with DTC followed in our tertiary care center between 2000–2022
were analyzed. Variables such as patient age, gender, preoperative serum
autoantibody levels, tumor characteristics, and treatment modalities were
obtained from medical records. The diagnosis of HT was based either on the
presence of a positive result in the pathological examination and/or on
antibody positivity. A total of 637 patients [mean±SD age,
44.9±13.5 years; 485 women [76.1%)] were included in the
analysis. The overall prevalence of coexistent HT was 22.9%
(n=146). The disease-specific mortality associated with DTC was
2.9%. DTC patients with HT compared to those without; have more positive
lymphovascular invasion (p<0.001), and lymph node metastases
(p<0.001). According to the Kaplan–Meier curves,
disease-specific survival rates among DTC patients without HT were significantly
higher than patients with HT (log-rank p=0.002). The disease-specific
mortality rate was 4.79% in DTC patients with HT, it was 1.43%
in those without HT. Hashimoto thyroiditis was not associated with a 10-year
recurrence-free survival (p=0.059). Differentiated thyroid cancers with
concomitant HT are associated with some aggressive tumor features (such as
lymphovascular invasion and nodal metastasis) and lower survival. In staging
systems based on tumor risk factors, it may be useful to evaluate the presence
of concomitant HT as a prognostic factor.
Mir-629 Repressed LATS2 Expression and Promoted the Proliferation of
Prostate Cancer Cells
Authors: Li Yuqiao , Zeng Sha , Cao Longbin 
Published: March 2023

AbstractMicroRNAs (miRNAs) have been discovered to play critical role in regulating
prostate cancer (PC) progression. The function role of miR-629 in tumor
progression of PC has not been studied. Here, we found that miR-629 was markedly
upregulated in PC as determined using the cancer genome atlas (TCGA) dataset,
clinical tissues, and cell lines. Functional analysis (MTT assays, colony
formation assays, soft agar growth assay and BrdU incorporation assay) indicated
that overexpression of miR-629 was drastically promoted, while miR-629-in
significantly suppressed cell proliferation. LATS2 was predicted as a direct
target of miR-629 and was confirmed by western blot and dual luciferase assay.
Through downregulation of large tumor suppressor 2 (LATS2) by overexpression of
miR-629, the p21 mRNA and protein were decreased while the Cyclin D3 mRNA and
protein were enhanced, suggesting promoting of cell proliferation process.
Additionally, knockdown of LATS2 reversed the inhibitory effect by miR-629-in in
PC. Our study indicated that miR-629 might serve as a new promising target for
PC treatment.
Standard Orbitozygomatic Craniotomy versus Mini Orbitozygomatic Craniotomy via an Eyebrow Incision for Microsurgical Treatment of Anterior Communicating Artery Aneurysms
Authors: Peters David R. , Mulvaney Graham , Monk Steve , Karimian Brandon , Wait Scott D. 
Published: March 2023

Abstract
Background Skull base approaches are utilized to improve microsurgical treatment of cerebral aneurysms. Advantages include early proximal and distal control, increased visualization, and minimal brain retraction. Orbitozygomatic (OZ) craniotomies via pterional incision are commonly used for the treatment of anterior communicating artery (ACoA) aneurysms. A smaller, less invasive OZ craniotomy performed through an eyebrow incision may provide several advantages over a standard OZ approach.
Objective We compare surgical outcomes of the standard and eyebrow OZ for the treatment of ACoA aneurysms.
Design All patients who underwent microsurgical treatment for ACoA aneurysms by a single surgeon over an 8-year period were included in this retrospective analysis. Patient demographics and clinical data were collected.
Participants Thirty-seven consecutive patients were identified, with 15 receiving eyebrow OZ and 22 receiving standard OZ.
Main Outcome Measures Data were collected on patient demographics, pathology, intraoperative and perioperative data, and 30-day morbidity.
Results A total of 100% of the eyebrow OZ group and 95.5% of the standard OZ group had complete aneurysmal occlusion. Four eyebrow OZ and six standard OZ patients had an intraoperative rupture. All were managed without complication. Two eyebrow OZ and one standard OZ patient died within 30 days of surgery. No patients in either group had aneurysm recurrence, required retreatment, or were limited intraoperatively by exposure.
Conclusions The OZ approach via an eyebrow incision has similar outcomes to a standard OZ approach and is a safe option for the treatment of ACoA aneurysms.
Comparison of Short-Term Hearing Outcome in Stapedotomy Using either Vein or Fat (Adipose Tissue) as Sealing Material
Authors: Velusamy Anand , Kavithadevi A. , Hameed Nazrin , Anand Aishwarya 
Published: March 2023

Abstract
Introduction Otosclerosis is a common cause of conductive hearing loss in the adult population that is caused by fixation of the stapes footplate. Cochlear otosclerosis may also present with sensorineural or mixed hearing loss. Surgery is the definitive treatment of choice and, during the procedure, sealing of the oval window with autologous tissue graft around the stapes prosthesis has been routinely done to improve hearing outcome and to mitigate postoperative complications.
Objective To evaluate the efficacy of two different types of autologous tissue (vein or fat) grafts as oval window sealing materials in stapedotomy in improving short-term hearing outcomes.
Methods In our study, 70 patients with otosclerosis who underwent primary stapedotomy were included. They were divided into group 1 (vein graft) and group 2 (fat graft) based on the type of sealing material used. All patients were followed-up at the end of 3 months, undergoing an audiometric examination to assess the hearing outcome.
Results A total of 80% (n = 28) of the patients in group1 had an air-bone gap (ABG) closure < 10dB, and, in group 2, 85.7% had an ABG closure < 10 dB; this difference was found to be statistically insignificant. A total of 42.9% (n = 15) of the patients in group 1 and of 31.4% (n = 11) in group 2 had a significant improvement in bone conduction, while 14.3% (n = 5) of the patients in group 1 and 17.1% (n = 6) in group 2 had worsening of average bone conduction postoperatively, which was found to be statistically insignificant.
Conclusion Both vein and fat grafts had comparable effects on hearing outcomes when used as sealing materials in stapedotomy.
Extramedullary Plasmacytoma: A Rare Entity
Authors: Mendieta Pastor Joaquín Ortiz , Tolentino Luciano Henrique Lenz , Centeno Deborah Marques , Guacho John Alexander Lata , Felipe Leika Miyahara , Maluf-Filho Fauze 
Published: March 2023

AbstractExtramedullary plasmacytoma is an immunoproliferative disease of mature B cell that produces immunoglobulins by clonal expansion. Plasma cell neoplasms are responsible for less than 0.1% of all pancreatic masses, they can be primary or secondary to multiple myeloma (MM). We present the case of a 56-year-old man with extramedullary solitary plasmacytoma located in the pancreas, presented with abdominal pain and jaundice. Imaging characteristics are similar to those of other pancreatic diseases, and the diagnosis is confirmed by immunohistochemistry due to the presence of a homogeneous infiltrate of monoclonal plasma cells, which typically express CD38 and CD 138 markers and the presence of kappa/lambda light chains.
Acceptance of Endoscopes in Otology – An Indian Perspective and Review of the Literature
Authors: Sharma Raman , Meher Ravi , Wadhwa Vikram , Soni Sanjay Vikram 
Published: March 2023

Abstract
Introduction The role of endoscopes in the ear, nose, and throat (ENT) field has been described since the 1980s; It started with endoscopic nasal surgeries, followed by otological and laryngological procedures, and, since then, it has experienced a rapid evolution. Endoscopes help otologists understand how to approach difficult areas of middle ear, as well as the physiology of middle ear cleft.
Objectives Despite the introduction of endoscopes in the field of otology, microscopes are still widely used in clinics and in operation theaters either alone or with endoscopes. The present study, which was conducted amongst otologists in India, is on their experience with and knowledge of the use of the endoscope compared to microscopes.
Methods A Google form-based questionnaire comprising 18 questions was developed and sent online to otologist all over the country. The final dataset included responses from 354 active otologists.
Results Out of 354 participants, only 3% had more than 5 years of experience in endoscopic ear surgery (EES), and 16.1% had never worked with an endoscope. Endoscopes were used in clinics and in operation theaters by 74.9% of the participants.
Conclusion There has been a rise in the acceptance and use of endoscopes among Indian otologists and otology surgeons in last few decades.
Multifocal Tuberculous Spondylitis and Extensive Extraspinal Tubercular Osteomyelitis without Immunocompromise: Case Report and Literature Review
Authors: Tomer Divya , Bartakke Girishchandra , Khose Shrikant 
Published: March 2023

AbstractMultifocal extensive spinal and extraspinal tuberculosis is very rare. So far, fewer than 10 cases have been reported. We hereby report two such cases to highlight their rarity, the diagnostic and therapeutic challenges they presented, and the overall prognosis of the condition. The two patients (a 19-year-old woman and another 20-year-old woman) had multifocal extensive tuberculosis involving spine and appendicular skeleton with neurological deficit. Both patients presented with back and neck pain and gradual neurological deficit. The insidious onset and malignancy-like spread pattern mimicked neoplasm. After thorough investigations with magnetic resonance imaging, positron emission tomography scan, and biopsy, antitubercular drug therapy was started, and debridement and fixation were done for significant thoracic and cervical vertebral lesions, respectively. Both patients showed excellent neurological recovery after the procedure. Early surgical treatment of the cases with large abscesses helped provide decompression and stabilization and prevented neurological deterioration and deformity. In patients with noncontiguous spinal tuberculosis, high percentage of surgical treatment may be required due to the aggressive behavior of the disease.
Accuracy of Evaluation of Fatty Liver with Third-Generation Unenhanced Dual-Energy CT and MRI: Prospective Comparison with MR Spectroscopy
Authors: Rajesh S. , Arunachalam Venkatesh Kasi , Periaswamy Gopinath , Kalyan Gobi , Renganathan Rupa , SM Gowtham , Cherian Mathew 
Published: March 2023

Abstract
Background and Objectives The purpose of this study is to evaluate and establish the accuracy of noninvasive methods, including third-generation dual-source dual-energy computed tomography (DECT) and proton density fat (PDF) fraction on magnetic resonance imaging (MRI) using three-dimensional multiecho multipoint chemical shift-encoded spoiled gradient echo (q-Dixon) sequence in the quantification of hepatic steatosis; with H1-MR spectroscopy (MRS) as the reference standard.
Materials and Methods A total of 47 patients were included in this prospective study. We studied the accuracy of fatty liver detection using third-generation DECT using mixed set images (MSIs), virtual monochromatic images (VMIs), and MRI q-Dixon. The results were compared with H1-MRS. Data were analyzed using linear regression for each technique compared with MRS.
Results Our study's correlation and linear regression analysis showed a good correlation between PDF values obtained by H1-MRS and MR q-Dixon methods (r = 0.821, r
2 = 0.674, p < 0.001). On MSI, H1-MRS showed a low correlation with average liver attenuation (r
2 = 0.379, p < 0.001) and a moderate correlation with liver attenuation index (r
2 = 0.508, p < 0.001) noted. There was a moderate correlation between H1-MRS and average liver attenuation and liver attenuation index on VMI at 80 to 120 keV with r
2 = 0.434, p < 0.001, and r
2 = 0.485, p < 0.001, respectively.
Conclusion MRI q-Dixon is the method of choice for evaluating fat quantification in the absence of H1 MRS. Among DECT images, VMI is valuable in the evaluation of hepatic fat as compared with the mixed set of images.
Revival of positive nostalgic music during the first Covid-19 lockdown in the UK: evidence from Spotify streaming data
Authors: Yeung Timothy Yu-Cheong 
Published: March 2023

AbstractThis work shows that positive old music listening surged during the early phase of the Covid-19 pandemic, suggesting a rise in preference for nostalgia and positivity in music. Using the music streaming data of Spotify users in the UK and employing multivariate regression analysis, this work documents that users were more likely to listen to songs older than 5 years during the national lockdown that began in late March 2020 compared with the pre-lockdown period. Such a change in preference was not observed in the same period in 2019. Meanwhile, more frequent listening to old music is found in samples of positive songs and also negative songs. This suggests that the preference for nostalgic music is to a certain extent independent of the positivity bias during the pandemic found in the literature. Yet, this work also provides evidence that the nostalgia-seeking behaviour and the preference for positive songs reinforced each other during the lockdown as the surge in positive old music was more persistent than that in positive recent music.