bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatics analysis and reveal potential crosstalk genetic and immune relationships between atherosclerosis and periodontitis
Authors: Dong Wenyuan , Gong Yuxin , Yang Bin , Li Bao 
Published: June 2023

AbstractPeriodontitis is an inflammatory and immune-related disease with links to several systemic diseases, and the pathological process of atherosclerosis also involves inflammatory and immune involvement. The aim of this study was to investigate the common immune cells and potential crosstalk genes between periodontitis (PD) and atherosclerosis (AS). By analyzing the weighted gene co-expression network of differentially immune infiltrating cells in two diseases to obtain important module genes, and taking the intersection of the module genes, we obtained 14 co-expressed immune-related genes, and evaluated the predictive value of 14 immune-related genes using three machine learning models.Two potential immune-related crosstalk genes (BTK and ITGAL) were finally obtained by taking intersections of WGCNA intersection genes, DEGs and IRGs.Then, the diagnostic column line graphs were constructed based on the 2 crosstalk genes, and the calibration curves, DCA curves and clinical impact curves indicated that the two genes had strong disease prediction ability, and we further validated the accuracy of the two potential crosstalk genes for disease diagnosis in the validation dataset.Single gene GSEA analysis showed that both genes are jointly involved in biological processes such as antigen presentation and immune regulation, and single sample GSEA analysis showed that macrophages and T cells play an important role in periodontitis in atherosclerosis.This study explored the genetic correlation between atherosclerosis and periodontitis using bioinformatics tools. BTK and ITGAL were found to be the most important crosstalk genes between the two diseases and may have an important role in the diagnosis and treatment of the diseases. Macrophage and T cell mediated inflammatory and immune responses may play an important role in periodontitis and atherosclerosis.
Spatial ecology of translocated raccoons
Authors: Hill Jacob E. , Helton James L. , Chipman Richard B. , Gilbert Amy T. , Beasley James C. , Dharmarajan Guha , Rhodes Olin E. 
Published: June 2023

AbstractRaccoons (Procyon lotor) are routinely translocated both legally and illegally to mitigate conflicts with humans, which has contributed to the spread of rabies virus across eastern North America. The movement behavior of translocated raccoons has important ramifications for disease transmission yet remains understudied and poorly quantified. To examine the spatial ecology of raccoons following experimental translocation, we performed reciprocal 16 km-distance translocations of 30 raccoons between habitats of high and low raccoon density (bottomland hardwood and upland pine, respectively) across the Savannah River Site (SRS) in Aiken, South Carolina, USA (2018–2019). Translocation influenced patterns of raccoon space use, with translocated animals exhibiting a 13-fold increase in 95% utilization distributions (UDs) post- compared to pre-translocation (mean 95% UD 35.8 ± 36.1 km2vs 1.96 ± 1.17 km2). Raccoons originating from upland pine habitats consistently had greater space use and larger nightly movement distances post-translocation compared to raccoons moved from bottomland hardwood habitats, whereas these differences were generally not observed prior to translocation. Estimated home ranges of male raccoons were twice the area as estimated for female raccoons, on average, and this pattern was not affected by translocation. After a transient period lasting on average 36.5 days (SD = 30.0, range = 3.25–92.8), raccoons often resumed pre-experiment movement behavior, with 95% UD sizes not different from those prior to translocation (mean = 2.27 ± 1.63km2). Most animals established new home ranges after translocation, whereas three raccoons moved > 16 km from their release point back to the original capture location. Four animals crossed a 100-m wide river within the SRS post-translocation, but this behavior was not documented among collared raccoons prior to translocation. Large increases in space use combined with the crossing of geographic barriers such as rivers may lead to elevated contact rates with conspecifics, which can heighten disease transmission risks following translocation. These results provide additional insights regarding the potential impacts of raccoon translocation towards population level risks of rabies outbreaks and underscore the need to discourage mesocarnivore translocations to prevent further spread of wildlife rabies.
Revisiting ‘revisiting supervised methods for effort‐aware cross‐project defect prediction’
Authors: Li Fuyang , Yang Peixin , Keung Jacky Wai , Hu Wenhua , Luo Haoyu , Yu Xiao 
Published: June 2023

AbstractEffort‐aware cross‐project defect prediction (EACPDP), which uses cross‐project software modules to build a model to rank within‐project software modules based on the defect density, has been suggested to allocate limited testing resource efficiently. Recently, Ni et al. proposed an EACPDP method called EASC, which used all cross‐project modules to train a model without considering the data distribution difference between cross‐project and within‐project data. In addition, Ni et al. employed the different defect density calculation strategies when comparing EASC and baseline methods. To explore the effective defect density calculation strategies and methods on EACPDP, the authors compare four data filtering methods and five transfer learning methods with EASC using four commonly used defect density calculation strategies. The authors use three classification evaluation metrics and seven effort‐aware metrics to assess the performance of methods on 11 PROMISE datasets comprehensively. The results show that (1) The classification before sorting (CBS+) defect density calculation strategy achieves the best overall performance. (2) Using balanced distribution adaption (BDA) and joint distribution adaptation (JDA) with the K‐nearest neighbour classifier to build the EACPDP model can find 15% and 14.3% more defective modules and 11.6% and 8.9% more defects while achieving the acceptable initial false alarms (IFA). (3) Better comprehensive classification performance of the methods can bring better EACPDP performance to some extent. (4) A flexible adjustment of the defect threshold λ of the CBS+ strategy contribute to different goals. In summary, the authors recommend researchers and practitioners use to BDA and JDA with the CBS+ strategy to build the EACPDP model.
Investigation of maternal serum hepassocin concentrations in pregnant
women with gestational diabetes mellitus: a prospective case-control
study
Authors: Cakmak Aysegul , Kale İbrahim , Muhcu Murat 
Published: June 2023

Abstract
Objective We aimed to investigate the relationship between gestational
diabetes mellitus (GDM) and maternal serum hepassocin concentrations.
Materials and methods This cross-sectional study was conducted with 88
pregnant women who applied to the Ümraniye Training and Research
Hospital Gynecology and Obstetrics Clinic between April 2022 and November 2022.
The GDM group consisted of 44 pregnant women who had a 75-g OGTT between the
24th and 28th week of pregnancy and were diagnosed with GDM. The control group
consisted of 44 healthy pregnant women who were matched with the GDM group in
terms of age and body mass index (BMI) and had a normal 75-g OGTT result.
Demographic characteristics, laboratory findings, and perinatal outcomes were
noted. Two groups were compared in terms of maternal serum hepassocin
concentrations.
Results Both groups were similar in terms of age, BMI, weight gain,
gravida, parity, polycystic ovary syndrome history, history of diabetes mellitus
in the family, and the gestational week at blood sampling for hepassocin
(p>0.05 for each). The median maternal serum hepassocin concentration
was found to be 18.21 ng/ml in the GDM group, while it was
determined as 13.05 ng/ml in the non-GDM group
(p=0.012). The GDM group was divided into two groups: the group that
only dieted until birth and the group that used insulin until birth for blood
glucose regulation. The median hepassocin concentration was found to be
17.99 ng/ml in the diet-only GDM group and
32.15 ng/ml in the insulin-using GDM group. ROC analysis was
performed to determine the value of maternal serum hepassocin concentration in
predicting GDM. AUC analysis of maternal serum hepassocin for estimation of GDM
was 0.656 (p=0.012, 95% CI=0.53–0.77). The
optimal threshold value for maternal serum hepassocin concentration was
determined as 14.13 ng/ml with 61.4% sensitivity and
61.4% specificity.
Conclusion Serum hepassocin concentration evaluated between 24 and 28
weeks of gestation was found to be higher in pregnant women with GDM than in the
non-GDM group. The highest serum hepassocin concentration was found in the GDM
group using insulin for blood glucose regulation. Hepassocin seems to be a
promising molecule that can be used in GDM screening in pregnant women who do
not want to have an OGTT in the future.
Diarylmethylamine (‘Butterfly’-Type Amine) Unit: A Useful Unit for the Modulation of the Catalytic Activity of Aminothiourea Catalysts
Authors: Mori Keiji , Ogawa Hiromasa , Okawa Hiroto 
Published: June 2023

AbstractWe investigated the effects of substituents on the aromatic rings in a diarylmethylamine unit (which we have named the ‘butterfly’-type amine unit) in an aminothiourea catalyst. Detailed examination of the electronic effects of the aromatic rings revealed that the catalyst having a 3,5-bis(trifluoromethyl)phenyl group was the best, realizing an excellent chemical yield and enantioselectivity in an asymmetric Michael reaction between nitrostyrene and dimethyl malonate. Importantly, its catalytic ability as a chiral catalyst is superior to that of the well-known aminothiourea catalyst, the Takemoto catalyst, and this characteristic was observed in various asymmetric reactions.
Quantum energy inequalities along stationary worldlines
Authors: Fewster Christopher J , Thompson Jacob 
Published: June 2023

Abstract
Quantum energy inequalities (QEIs) are lower bounds on the averaged energy density of a quantum field. They have been proved for various field theories in general curved spacetimes but the explicit lower bound is not easily calculated in closed form. In this paper we study QEIs for the massless minimally coupled scalar field in four-dimensional Minkowski spacetime along stationary worldlines—curves whose velocity evolves under a 1-parameter Lorentz subgroup—and find closed expressions for the QEI bound, in terms of curvature invariants of the worldline. Our general results are illustrated by specific computations for the six prototypical stationary worldlines. When the averaging period is taken to infinity, the QEI bound is consistent with a constant energy density along the worldline. For inertial and uniformly linearly accelerated worldlines, this constant value is attained by the Minkowski and Rindler vacuums respectively. It is an open question as to whether the bounds for other stationary worldlines are attained by other states of interest.
A quintuple plasmon-induced transparency multifunction switch based on the polarization-sensitive graphene-based metamaterial
Authors: Ji Cheng , Liu Zhimin , Zhou Fengqi , Luo Xin , Yang Guangxin , Xie Yadong , Yang Ruihan 
Published: June 2023

Abstract
A monolayer metamaterial consisting of a rectangle graphene strip and four L-shaped graphene blocks was proposed to achieve a quintuple plasmon-induced transparency (quintuple-PIT). The numerical simulation results based on the finite difference time domain method agree well with the calculated results of the coupled mode theory. By modulating the Fermi energy level of graphene, an octuple-frequency asynchronous switch and a sextuple-frequency synchronous switch are designed and studied, which have excellent amplitude modulation degree (up to 97.7%), extinction ratio (up to 16.41 dB), insertion loss (low to 5.4%), and dephasing time(low to 3.86 ps). Furthermore, the results show that the proposed metamaterials has polarization-sensitive characteristics due to their non-central symmetry. Further research shows that the group index is as high as 604 which has a good slow light effect and can be used for optical storage. Hence, the quintuple-PIT proposed structure in this paper has good application value in the expansion of multi-function optical switches and the research of high-quality optical memory.
A similarity-based remaining useful life prediction method using multimodal degradation features and adjusted cosine similarity
Authors: Kong Chengcheng , Yu Wennian , Zeng Qiang , Chen Zixu , Peng Yizhen 
Published: June 2023

Abstract
When a large amount of full life-cycle data are available, similarity-based methods are the preferred method for remaining useful life (RUL) prediction due to their reliability and accuracy. Traditional similarity-based RUL prediction methods use a single model and single-scale degradation features, which are incapable of fully capturing the degradation behavior of the system. Additionally, the similarity of spatial orientation is neglected in the similarity-matching process. To fill these research gaps, a novel method is developed based on multimodal degradation features and adjusted cosine similarity (ACS) to tackle complex-system RUL prediction in this paper. Complete ensemble empirical mode decomposition with adaptive noise is employed to decouple global degradation and random fluctuations in run-to-failure sensor data. Slow feature analysis is utilized to obtain local degradation features, and residual terms are used as global degradation features. Then, multimodal degradation features are transformed into one-dimensional health degradation indicators by bidirectional gated recurrent unit autoencoder. An ACS is developed to estimate the matching similarity between the test degradation curve and the training degradation curve. The proposed scheme captures the time-varying multimodal degradation behavior and provides libraries of health curves with multiple degradation patterns. The designed scheme is evaluated on the C-MAPSS dataset and the results illustrate the competitiveness and effectiveness of the proposed method.
Inner–outer dual space protection of free-standing MoS2 anodes via electrospinning for stable lithium-ion storage
Authors: Lin Jian , Li Yanfei , Song Yihan , Zhang Jingping , Xie Haiming , Sun Haizhu 
Published: June 2023

Abstract
Although significant achievements in improving the stability of MoS2 anodes have been made, the cycling life in most studies is still less than 1000 cycles. This is because MoS2 anodes directly contact the electrolyte and generate byproducts, leading to the loss of active mass and capacity decay. Herein, the inner–outer dual space protection of MoS2 fibers is realized by regulating the surface and interface structure of electrospinning precursors (noted as X-MoS2/CNFs). Inside the fibers, Mo–N covalent bond is constructed to anchor the active material, preventing MoS2 from falling off the matrix after multiple cycles. Simultaneously, surface of the fibers, a stable solid electrolyte interface layer is induced to prevent contact between active materials and electrolytes. In addition, the initial Coulombic efficiency is enhanced as high as 84.4%. The profound investigations of morphological evolution and internal real-time resistance confirm the double structural protection of 800-MoS2/CNFs. As a result, a decent cycling performance (408.9 mAh g−1 at 1000 mA g−1 for 2000 cycles) and the satisfied rate capacities (100–1000 mA g−1) are achieved. This work provides a new idea for the preparation of stable anodes for alkali metal ion secondary batteries.
Trends in the use of psychotropics in older people with dementia: interrupted time series of Finnish clinical guidelines of behavioural and psychological symptoms of dementia
Authors: Rantsi Mervi , Kortelainen Lauri , Hyttinen Virva , Jyrkkä Johanna , Kankaanpää Eila 
Published: June 2023

Abstract

Background
Up to 90% of people with dementia experience behavioural and psychological symptoms of dementia (BPSD) as part of their illness. Psychotropics are not recommended as the first-line treatment of BPSD because older people are more prone to adverse reactions. In this study, we evaluate the impact of the Finnish clinical guidelines of BPSD (published in 2017) on psychotropic use in people with dementia.

Methods
This study is based on Finnish Prescription Register data from 2009 to 2020. The data included all community-dwelling Finnish people aged ≥65 and who had anti-dementia medication purchases (n = 217,778). We used three-phased interrupted time series design to evaluate the changes in levels and trends of monthly (n = 144) psychotropic user rates compared with the predicted trends. In addition, we evaluated the changes in levels and trends of monthly new psychotropic user rates.

Results
The level of monthly psychotropic user rate decreased non-significantly during the intervention period (β −0.057, P = 0.853), and during the post-intervention period, there was an increase in the level (β 0.443, P = 0.091) and slope (β 0.199, P = 0.198), but not statistically significant. The level of monthly new psychotropic user rate (β −0.009, P = 0.949) during the intervention period and the level (β 0.044, P = 0.714) and slope (β 0.021, P = 0.705) during the post-intervention period were almost unchanged.

Conclusions
Results may indicate possible challenges in deprescribing and better adherence to the guidelines at the beginning of BPSD treatment. Further research into the barriers to implement BPSD guidelines and the availability of non-pharmacological treatments is needed.
Human in vitro-induced IL-17A+ CD8+ T-cells exert pro-inflammatory effects on synovial fibroblasts
Authors: Gray Elizabeth H , Srenathan Ushani , Durham Lucy E , Lalnunhlimi Sylvine , Steel Kathryn J A , Catrina Anca , Kirkham Bruce W , Taams Leonie S 
Published: June 2023

Abstract
IL-17A+ CD8+ T-cells, termed Tc17 cells, have been identified at sites of inflammation in several immune-mediated inflammatory diseases. However, the biological function of human IL-17A+ CD8+ T-cells is not well characterized, likely due in part to the relative scarcity of these cells. Here, we expanded IL-17A+ CD8+ T-cells from healthy donor PBMC or bulk CD8+ T-cell populations using an in vitro polarization protocol. We show that T-cell activation in the presence of IL-1β and IL-23 significantly increased the frequencies of IL-17A+ CD8+ T-cells, which was not further enhanced by IL-6, IL-2, or anti-IFNγ mAb addition. In vitro-generated IL-17A+ CD8+ T-cells displayed a distinct type-17 profile compared with IL-17A− CD8+ T-cells, as defined by transcriptional signature (IL17A, IL17F, RORC, RORA, MAF, IL23R, CCR6), high surface expression of CCR6 and CD161, and polyfunctional production of IL-17A, IL-17F, IL-22, IFNγ, TNFα, and GM-CSF. A significant proportion of in vitro-induced IL-17A+ CD8+ T-cells expressed TCRVα7.2 and bound MR1 tetramers indicative of MAIT cells, indicating that our protocol expanded both conventional and unconventional IL-17A+ CD8+ T-cells. Using an IL-17A secretion assay, we sorted the in vitro-generated IL-17A+ CD8+ T-cells for functional analysis. Both conventional and unconventional IL-17A+ CD8+ T-cells were able to induce pro-inflammatory IL-6 and IL-8 production by synovial fibroblasts from patients with psoriatic arthritis, which was reduced upon addition of anti-TNFα and anti-IL-17A neutralizing antibodies. Collectively, these data demonstrate that human in vitro-generated IL-17A+ CD8+ T-cells are biologically functional and that their pro-inflammatory function can be targeted, at least in vitro, using existing immunotherapy.
Understanding the concept of a novel tool requires interaction of the dorsal and ventral streams
Authors: Seidel Gundula , Rijntjes Michel , Güllmar Daniel , Weiller Cornelius , Hamzei Farsin 
Published: June 2023

Abstract
The left hemisphere tool-use network consists of the dorso-dorsal, ventro-dorsal, and ventral streams, each with distinct computational abilities. In the dual-loop model, the ventral pathway through the extreme capsule is associated with conceptual understanding. We performed a learning experiment with fMRI to investigate how these streams interact when confronted with novel tools. In session one, subjects observed pictures and video sequences in real world action of known and unknown tools and were asked whether they knew the tools and whether they understood their function. In session two, video sequences of unknown tools were presented again, followed again by the question of understanding their function. Different conditions were compared to each other and effective connectivity (EC) in the tool-use network was examined. During concept acquisition of an unknown tool, EC between dorsal and ventral streams was found posterior in fusiform gyrus and anterior in inferior frontal gyrus, with a functional interaction between BA44d and BA45. When previously unknown tools were presented for a second time, EC was prominent only between dorsal stream areas. Understanding the concept of a novel tool requires an interaction of the ventral stream with the dorsal streams. Once the concept is acquired, dorsal stream areas are sufficient.
A Behavioural Theory of Discrimination in Policing
Authors: Hübert Ryan , Little Andrew T 
Published: June 2023

Abstract
A large economic literature studies whether racial disparities in policing are explained by animus or by beliefs about group crime rates. But what if these beliefs are incorrect? We analyse a model where officers form beliefs using crime statistics, but do not properly account for the fact that they will detect more crime in more heavily policed communities. This creates a feedback loop where officers over-police groups that they (incorrectly) believe exhibit high crime rates. This inferential mistake can exacerbate discrimination even among officers with no animus and who sincerely believe that disparities are driven by real differences in crime rates.