bluuebunny/crossref_metadata_2025_split huggingface dataset:
Miniaturen auf der Wasseroberfläche
Authors: Suhr Wilfried , Schlichting Hans Joachim 
Published: July 2023

ZusammenfassungAuf der Oberfläche von Gewässern kann man häufig kleine Objekte wie Tannennadeln, Blätter und ähnliche Dinge driften sehen, die sich kollektiv zu interessanten Mustern vereinigen. Dieses Verhalten lässt sich auf wechselseitige Anziehung oder Abstoßung der zugehörigen Wassermenisken zurückführen und durch die Physik der Grenzflächen erklären. In Analogie zur Wechselwirkung zwischen elektrischen Ladungen ordnen wir den driftenden Teilchen eine Polarität zu und beschreiben die Interaktionen der Teilchen mit Hilfe energetischer Prinzipien. Beispiele zur Musterbildung mit einfach konstruierten Objekten geben Anregungen zum eigenen spielerischen und gegebenenfalls künstlerischen Tun.
Adolescents' experiences of Help Overcoming Pain Early—A school based person‐centred intervention for adolescents with chronic pain
Authors: Wallbing U. , Nilsson S. , Wigert H. , Lundberg M. 
Published: July 2023

AbstractTo illuminate adolescents' experiences of Help Overcoming Pain Early (HOPE), a person‐centred intervention delivered in a school setting by school nurses. Twenty‐one adolescents with chronic pain recruited from secondary school, who had completed the HOPE intervention, were included in the interview study. The HOPE intervention was built on person‐centred ethics and consisted of four meetings between school nurses and adolescents on the subject of stress and pain management. A qualitative method using content analysis with an inductive approach was employed. In the interviews, the adolescents describe how they reclaim their lives with the help of HOPE. They use different strategies and parts of the intervention to move on with their lives. A trustful relationship, as that with the school nurse, was essential to dare to change. The overarching theme summarizes in Becoming myself again and is built up by three sub‐themes: Trust a pillar for growth, Making sense of my life with pain, and Putting myself into the world again. A person‐centred intervention such as HOPE applied in a school context is promising for promoting confidence in adolescents with chronic pain. A trust‐building process emerged, in terms of both the adolescents' trust in the healthcare staff they meet and their confidence in their own ability to handle and influence their situation, which in the long term can promote trust in themselves as a person.
Comparative study on the rheological properties of cellulose acetate and double‐base propellant
Authors: Hu Qipeng , Gu Han , Zhang He , Li Chunzhi , Ying Sanjiu , Xiao Zhongliang 
Published: July 2023

AbstractCellulose acetate (CA) and nitrocellulose (NC) are both cellulose derivatives with similar chemical structure and physical properties, and CA are non‐flammable and biodegradable, so CA has been used as a safe substitute to NC for artillery propellant research. The ester functional groups of CA and NC are different, and there are other components in the propellant, so the rheological properties of CA and propellant can be different slightly. However, the comparative study of rheological properties between CA and propellant is rarely reported. In this paper, the rheological properties of CA and double‐base propellant (DP) in extrusion process was studied by in‐line slit rheometer. The results show that the power‐law model can describe the rheological properties of CA and DP well. The shear viscosity of CA and DP decreases gradually with the increase of solvent ratio, and when the solvent ratio of CA is 0.87 and that of DP is 0.34, the rheological properties of CA and DP are most similar. The Arrhenius equation can reflect the relationship between shear viscosity and temperature of CA and DP, and the viscous activation energy of CA is about 23.68 kJ/mol, while that of DP is about 7.38 kJ/mol. In general, the effect of temperature on the rheological properties of CA is stronger than that of DP.
The complex II resistance mutation H258Y in succinate dehydrogenase subunit B causes fitness penalties associated with mitochondrial respiratory deficiency
Authors: Njiru Christine , Saalwaechter Corinna , Mavridis Konstantinos , Vontas John , Geibel Sven , Wybouw Nicky , Van Leeuwen Thomas 
Published: July 2023

AbstractBACKGROUNDThe acaricides cyflumetofen, cyenopyrafen and pyflubumide inhibit the mitochondrial electron transport chain at complex II [succinate dehydrogenase (SDH) complex]. A target site mutation H258Y was recently discovered in a resistant strain of the spider mite pest Tetranychus urticae. H258Y causes strong cross‐resistance between cyenopyrafen and pyflubumide, but not cyflumetofen. In fungal pests, fitness costs associated with substitutions at the corresponding H258 position that confer resistance to fungicidal SDH inhibitors have not been uncovered. Here, we used H258 and Y258 near‐isogenic lines of T. urticae to quantify potential pleiotropic fitness effects on mite physiology.RESULTSThe H258Y mutation was not associated with consistent significant changes of single generation life history traits and fertility life table parameters. In contrast, proportional Sanger sequencing and droplet digital polymerase chain reaction showed that the frequency of the resistant Y258 allele decreased when replicated 50:50 Y258:H258 experimentally evolving populations were maintained in an acaricide‐free environment for approximately 12 generations. Using in vitro assays with mitochondrial extracts from resistant (Y258) and susceptible (H258) lines, we identified a significantly reduced SDH activity (48% lower activity) and a slightly enhanced combined complex I and III activity (18% higher activity) in the Y258 lines.CONCLUSIONOur findings suggest that the H258Y mutation is associated with a high fitness cost in the spider mite T. urticae. Importantly, while it is the most common approach, it is clear that only comparing life history traits and life table fecundity does not allow to reliably estimate fitness costs of target site mutations in natural pest populations. © 2023 Society of Chemical Industry.
The MRC Dyspnoea Scale and mortality risk prediction in pulmonary arterial hypertension: A retrospective longitudinal cohort study
Authors: Arogundade Folawemimo , Jani Bhautesh , Church Colin , Brewis Melanie , Johnson Martin , Stubbs Harrison 
Published: July 2023

AbstractRisk stratification models in pulmonary arterial hypertension (PAH) rely on World Health Organisation Functional Class (WHO FC). A high proportion of patients are classified as WHO FC III, a heterogenous group which limits the stratification abilities of risk models. The Medical Research Council (MRC) Dyspnoea Scale may allow a more precise assessment of functional status and improve current risk models. We investigated the ability of the MRC Dyspnoea Scale to assess survival in PAH and compared performance to WHO FC and the COMPERA 2.0 models. Patients with Idiopathic, Hereditary or Drug‐induced PAH who were diagnosed between 2010 and 2021 were included. The MRC Dyspnoea Scale was retrospectively applied as derived from a combination of patient notes, 6MWD tests results and WHO functional status using a purpose‐designed algorithm. Survival was assessed using Kaplan–Meier analyses, log rank testing and Cox proportional hazard ratios. Model performance was compared with Harrell's C Statistic. Data from 216 patients were retrospectively analyzed. At baseline, of 120 patients classified as WHO FC III, 8% were MRC Dyspnoea Scale 2, 12% Scale 3, 71% Scale 4 and 10% Scale 5. The MRC Dyspnoea Scale performed well compared to the WHO FC and COMPERA models at follow up (respectively, C‐statistic 0.74 vs. 0.69 vs. 0.75). It was possible to use the MRC Dyspnoea Scale to subdivide patients in WHO FC III into groups which had distinct survival estimates. We conclude that at follow‐up, the MRC Dyspnoea Scale may be a valid tool for the assessment of risk stratification in pulmonary arterial hypertension.
Spatial and temporal resolution of metabolic dysregulation in the Sugen hypoxia model of pulmonary hypertension
Authors: Simpson Catherine E. , Ambade Anjira S. , Harlan Robert , Roux Aurelie , Graham David , Klauer Neal , Tuhy Tijana , Kolb Todd M. , Suresh Karthik , Hassoun Paul M. , Damico Rachel L. 
Published: July 2023

AbstractAlthough PAH is partially attributed to disordered metabolism, previous human studies have mostly examined circulating metabolites at a single time point, potentially overlooking crucial disease biology. Current knowledge gaps include an understanding of temporal changes that occur within and across relevant tissues, and whether observed metabolic changes might contribute to disease pathobiology. We utilized targeted tissue metabolomics in the Sugen hypoxia (SuHx) rodent model to investigate tissue‐specific metabolic relationships with pulmonary hypertensive features over time using regression modeling and time‐series analysis. Our hypotheses were that some metabolic changes would precede phenotypic changes, and that examining metabolic interactions across heart, lung, and liver tissues would yield insight into interconnected metabolic mechanisms. To support the relevance of our findings, we sought to establish links between SuHx tissue metabolomics and human PAH ‐omics data using bioinformatic predictions. Metabolic differences between and within tissue types were evident by Day 7 postinduction, demonstrating distinct tissue‐specific metabolism in experimental pulmonary hypertension. Various metabolites demonstrated significant tissue‐specific associations with hemodynamics and RV remodeling. Individual metabolite profiles were dynamic, and some metabolic shifts temporally preceded the emergence of overt pulmonary hypertension and RV remodeling. Metabolic interactions were observed such that abundance of several liver metabolites modulated lung and RV metabolite‐phenotype relationships. Taken all together, regression analyses, pathway analyses and time‐series analyses implicated aspartate and glutamate signaling and transport, glycine homeostasis, lung nucleotide abundance, and oxidative stress as relevant to early PAH pathobiology. These findings offer valuable insights into potential targets for early intervention in PAH.
The association between early fluid strategy and prognosis of acute respiratory distress syndrome: A post hoc study of CHARDS
Authors: Chen Ziying , Huang Xu , Lu Haining , Deng Wang , Huang Linna , Wu Dawei , Wang Daoxin , Zhan Qingyuan , Wang Chen 
Published: July 2023

AbstractWe aimed to assess general fluid management in China and evaluate the association between fluid balance and survival outcomes in acute respiratory distress syndrome (ARDS) patients. A retrospective, multicenter study including ARDS patients was conducted. We described the fluid management of ARDS patients in China. Furthermore, clinical characteristics and outcomes of patients subdivided by cumulative fluid balance were also analyzed. Multivariable logistic regression analysis was performed with hospital mortality as the outcome. From June 2016 to February 2018, 527 ARDS patients were included in our study. The mean cumulative fluid balance was 1669 (−1101 to 4351) mL in the first 7 day after intensive care unit (ICU) admission. Patients were divided into four groups based on cumulative fluid balance of the first 7 day after ICU admission: Group I (≤0 L), Group II (>0 L, ≤3 L), Group III (>3 L, ≤5 L), and Group IV (>5 L). Significantly lower hospital mortality was observed in patients with a lower cumulative fluid balance on day 7 of ICU admission (20.5% in Group I vs. 32.8% in Group II, 38.5% in Group III, and 50% in Group IV, p < 0.001). A lower fluid balance is associated with lower hospital mortality in patients with ARDS. However, a large‐scale and well‐designed randomized controlled trial is needed in the future.
Sensitivity and robustness of randomization test and F‐test in some experimental designs
Authors: Oladugba Abimibola Victoria , Ugwu Chibuike Emmanuel , Onwuamaeze Uchenna Charity 
Published: July 2023

AbstractThis work examined the sensitivity of randomization test and F‐test in completely randomized design, randomized complete block design and Latin square design in order to ascertain which is more robust in terms of power (sensitivity) of the test and type I error rate in cases with normal error, skewed error (Chi‐square and Exponential distributions), by varying the sample sizes. Using Monte Carlo simulation, response observations were generated for normal error, skewed error at various sample sizes for each of the experimental designs. The results showed that for the normal error, the power and type I error rate of the F‐test were slightly smaller and greater respectively in each of the designs than that of the randomization test. Furthermore, for the skewed error, the randomization test was more sensitive than the F‐test, and also, the type I error was smaller in each of the designs.
A Novel Gateway to InCl3 catalyzed N‐Formylation of Amines: An Access to 2‐unsubstituted, N‐unsubstituted Benzimidazoles
Authors: Sharma Bikash , Ghosh Anjulika , Dubey Manoj Kumar , Bandichhor Rakeshwar , Das Saibal Kumar 
Published: July 2023

AbstractThis article deals with a simple indium(III) chloride catalysed procedure in acetonitrile under mild condition for N‐formylation for a wide variety of amines. The reaction condition was extended to the chemoselective N‐formylation of amino groups as well. Using o‐phenylenediamines in place of mono‐amines, unsubstituted 1H‐benzimidazoles could also be accessed.
Novel WS2/Co9S8 nanoparticles supported on N, S co‐doped mesoporous carbon as efficient electrocatalyst for hydrogen evolution reaction
Authors: Bi Xinyue , Xu Jing , Zhang Wenting , Tang Duihai , Zhang Ke , Xin Shigang , Zhao Zhen 
Published: July 2023

AbstractA series of WS2/Co9S8 nanoparticles (NPs) supported on N, S co‐doped mesoporous carbons were prepared via the molten salts process. Glucose, WCl6 and CoCl2 were used as carbon, tungsten and cobalt precursors, respectively. Thiourea were utilized as nitrogen and sulfur precursor. The common inorganic salts were the porogens, which can be removed and recycled. The molar ratio of the precursors can affect the porosities of the catalysts, which can further determine the electrocatalytic performance. The sample of G2.5TWCo shows the best HER performance due to the high electrochemically active surface area and low electrochemical impedance.
Iron(II) and cobalt(II) Complexes of 3,4‐Dihydroxybenzaldehyde‐4‐ethylthiosemicarbazone: Synthesis, Spectral Studies and Molecular Docking
Authors: Kayed Safa Faris 
Published: July 2023

AbstractFe(II) and Co(II) complexes of 3,4‐dihydroxybenzaldehyde 4‐ethylthiosemicarbazone were synthesized and characterized by elemental analysis (CHNS), magnetic susceptibility measurements, molar conductivity, Fourier transform infrared (FT‐IR), nuclear‐magnetic resonance (1H‐NMR and 13C‐NMR) and ultraviolet‐visible (UV‐Vis) spectra. The spectral and analytical data revealed that the obtained thiosemicarbazone‐metal complexes have tetrahedral geometry around the metal center. The studied ligand acts as a bidentate ligand by using both azomethine nitrogen and thiol sulphur as monoanion center of donation. To predict the reactive sites for electrophilic and nucleophilic attack, the Molecular Electrostatic Potential (MEP) was determined. The antibacterial activities of 3,4‐dihydroxybenzaldehyde 4‐ethylthiosemicarbazone ligand and its complexes were tested by molecular docking technique into the crystal structure of topoisomerase II and topoisomerase IV proteins. Molecular docking investigation proved that, the ligand and its complexes had interesting interactions with active sites of amino acids of the target proteins. The Co(II) complex exhibited better potential inhibition than other studied compounds.
Synthesis, Spectroscopic (FT‐IR, FT‐Raman), Electronic Properties and Molecular Docking Studies of 1‐(2, 6‐dibromo‐4‐methyl‐phenoxymethyl)‐benzo[f]chromen‐3‐one
Authors: Hiremath Sudhir M. , Khemalapure Seema S. 
Published: July 2023

AbstractHerein, 1‐(2,6‐dibromo‐4‐methyl‐phenoxymethyl)‐benzo[f]chromen‐3‐one (DBMPBC) is chosen to be thoroughly investigated in terms of structural, spectroscopic (FT‐IR, FT‐Raman) and molecular electronic properties based on density functional theory (DFT). The title molecule is synthesized by the reaction of 5,6‐benzo‐4‐bromomethylcoumarin with 2,6‐dibromo‐4‐methylphenol in presence of anhydrous potassium carbonate in dry acetone. All the computational studies for the selected structure are carried out at the theoretical level DFT/B3LYP/6‐311++G (d, p). The theoretically determined geometrical parameters from optimized structure and experimental values are compared to each other to confirm the structural properties of the molecule. The vibrational wavenumbers are studied by FT‐IR and FT‐Raman spectral techniques in both experimental and computational methods and compared to each other. The detailed vibrational assignments are assigned through potential energy distribution method by VEDA. The MEP surface analysis is carried out in order to identify the potential sites of electrophilic and nucleophilic attack. The Natural Bond Orbital (NBO) study significantly verified the existence of the intermolecular interactions in the molecule. The stability and reactivity properties of the molecule are estimated in terms of HOMO‐LUMO energies. Molecular docking investigations are carried out to simulate the inhibitory impact of the title molecule against the VEGFR2 (PDB: 2XIR) and PI3K (PDB: 2RDO) receptors for anti‐angiogenic therapy in the treatment of NSCLC. ADMET parameters and toxicity properties of the title molecule is conducted.
A Halogen‐Bonded Organic Framework (XOF) Emissive Cocrystal for Acid Vapor and Explosive Sensing, and Iodine Capture
Authors: Maji Suman , Natarajan Ramalingam 
Published: July 2023

AbstractThere is a strong and urgent need for efficient materials that can capture radioactive iodine atoms from nuclear waste. This work presents a novel strategy to develop porous materials for iodine capture by employing halogen bonding, mechanochemistry and crystal engineering. 3D halogen‐bonded organic frameworks (XOFs) with guest‐accessible permanent pores are exciting targets in crystal engineering for developing functional materials, and this work reports the first example of such a structure. The new‐found XOF, namely TIEPE‐DABCO, exhibits enhanced emission in the solid state and turn‐off emission sensing of acid vapors and explosives like picric acid in nanomolar quantity. TIEPE‐DABCO captures iodine from the gas phase (3.23 g g−1 at 75 °C and 1.40 g g−1 at rt), organic solvents (2.1 g g−1), and aqueous solutions (1.8 g g−1 in the pH range of 3–8); the latter with fast kinetics. The captured iodine can be retained for more than 7 days without any leaching, but readily released using methanol, when required. TIEPE‐DABCO can be recycled for iodine capture several times without any loss of storage capacity. The results presented in this work demonstrate the potential of mechanochemical cocrystal engineering with halogen bonding as an approach to develop porous materials for iodine capture and sensing.
Reversed phase‐high‐performance liquid chromatography simultaneous estimation of phenolic compounds in hydroalcoholic extract of Potentilla fulgens root
Authors: Chaudhary Sushil Kumar , Sharma K. Chandradev , Sarangthem Indira , Kar Amit , Bhardwaj Pardeep Kumar , Sharma Nanaocha , Mukherjee Pulok K. 
Published: July 2023

AbstractThe roots of Potentilla fulgengs have been utilized for a long time as an astringent and tonic for treating gum and tooth diseases, microbial contagions, inflammation, diabetes mellitus, and wounds and are rich in polyphenols and flavonoids. Authentication and constant excellence are the rudimentary limitations of herbal medicines and their complexity is a key challenge for quality control. High‐performance liquid chromatography has become an important technique for the quality control of herbal medicines because of its simplicity and uniformity. It can be applied for the identification, confirmation, and quality control of herbal medicines. So, an approach using reversed‐phase high‐performance liquid chromatography was developed and validated for the simultaneous determination of phenolic compounds in the hydroalcoholic extract (methanol:water::70:30% v/v) of Potentilla fulgens roots. The results revealed that ellagic acid was found in the highest amount (8.191 ± 0.463 mg/g) followed by rutin (5.429 ± 0.062 mg/g) and caffeic acid (3.032 ± 0.453 mg/g) among the studied phenolic compounds while quercetin was not detected. The validation parameters involved selectivity, linearity, range, limits of detection and quantitation, precision, and accuracy. All calibration curves were linear (R2 > 0.99) within the range, and good precision (relative standard deviation < 2.0%) and recovery (96.129%–117.110%) were found for all standards.
Sustainable use of water from a tropical aquifer
Authors: Huguet‐Sierra Gerardo Arturo , Márquez‐Romance Adriana Mercedes , Guevara‐Pérez Edilberto , Pérez‐Pacheco Sergio Alejandro , Buroz‐Castillo Eduardo 
Published: July 2023

AbstractThe objective of this work is to analyze and interpret the components or hydrogeological, physical, and chemical variables of the San Diego aquifer to describe it and explain its influence on the sustainable use of groundwater for the providing of this locality. The San Diego municipality covers most of the area of the aquifer and is an area of high urban development that currently needs the contribution of groundwater due to the deficit presented by the main supply from the Central Regional System. Said aquifer is a set of geological strata located within the limits of the San Diego River basin, in the state of Carabobo, which are capable of storing groundwater and transmitting it. Data on lithology, porosity, and pumping level were investigated, which allows calculating an estimate of the volume of water available in the aquifer. Regarding the quality of the water, the data on hardness, chlorides, sulfates, nitrates, conductivity, calcium, magnesium, and pH, show that the water towards the center and north of the aquifer is of good quality, being able to classify it as type 1A, while toward the southern end—this is of lower quality, where the mineral parameters are higher, which is related to the probable intrusion of brackish water from Lake Valencia. It is concluded by establishing that the volume of groundwater, its availability, extraction feasibility, and its quality, make it suitable for urban supply and that said extraction is sustainable. But a better‐integrated type of management must be designed, considering the contribution of the Regional System of the Center and the adequacy of the distribution networks.
Clinical practice guideline on bladder cancer (Part I)
Authors: Dong Xiying , Song Gang , Guan Kaopeng , Wang Tie , Feng Xiaoli , Liu Yulin , Liu Min , Ji Zhigang , Li Xiao , Li Jiongming , Zhang Yong , Zhou Fangjian , Zhou Aiping , Xu Wanhai , Xu Tao , Gao Xianshu , Zhai Qing , Wei Qiang , Xing Nianzeng 
Published: July 2023

AbstractBladder cancer represents one of the most prevalent malignant tumors affecting the urinary system. As per data disclosed by the National Cancer Registration Center of China in 2019, the incidence of bladder cancer was 5.80 per 100,000 in 2015, placing it as the thirteenth most common systemic malignancy. Bladder cancer poses a substantial threat to public health in China, underlining the critical importance of standardizing diagnosis and treatment to enhance clinical outcomes. This clinical practice guideline for bladder cancer centers on the etiologies, clinical presentations, and diagnostic procedures for suspected bladder cancer, in addition to the histopathology and staging of urothelial bladder cancer.