bluuebunny/crossref_metadata_2025_split huggingface dataset:
False Discovery Rate-Controlled Multiple Testing for Union Null Hypotheses: A Knockoff-Based Approach
Authors: Dai Ran , Zheng Cheng 
Published: March 2023

AbstractFalse discovery rate (FDR) controlling procedures provide important statistical guarantees for replicability in signal identification based on multiple hypotheses testing. In many fields of study, FDR controling procedures are used in high-dimensional (HD) analyses to discover features that are truly associated with the outcome. In some recent applications, data on the same set of candidate features are independently collected in multiple different studies. For example, gene expression data are collected at different facilities and with different cohorts, to identify the genetic biomarkers of multiple types of cancers. These studies provide us with opportunities to identify signals by considering information from different sources (with potential heterogeneity) jointly. This paper is about how to provide FDR control guarantees for the tests of union null hypotheses of conditional independence. We present a knockoff-based variable selection method (Simultaneous knockoffs) to identify mutual signals from multiple independent datasets, providing exact FDR control guarantees under finite sample settings. This method can work with very general model settings and test statistics. We demonstrate the performance of this method with extensive numerical studies and two real-data examples.
Cancer cell‐derived CD69 induced under lipid and oxygen starvation promotes ovarian cancer progression through fibronectin
Authors: Koizume Shiro , Kanayama Tomohiko , Kimura Yayoi , Hirano Hisashi , Takahashi Tomoko , Ota Yukihide , Miyazaki Kaoru , Yoshihara Mitsuyo , Nakamura Yoshiyasu , Yokose Tomoyuki , Kato Hisamori , Takenaka Katsuya , Sato Shinya , Tadokoro Hiroko , Miyagi Etsuko , Miyagi Yohei 
Published: March 2023

AbstractCancer tissues generally have molecular oxygen and serum component deficiencies because of poor vascularization. Recently, we revealed that ICAM1 is strongly activated through lipophagy in ovarian clear cell carcinoma (CCC) cells in response to starvation of long‐chain fatty acids and oxygen and confers resistance to apoptosis caused by these harsh conditions. CD69 is a glycoprotein that is synthesized in immune cells and is associated with their activation through cellular signaling pathways. However, the expression and function of CD69 in nonhematological cells is unclear. Here, we report that CD69 is induced in CCC cells as in ICAM1. Mass spectrometry analysis of phosphorylated peptides followed by pathway analysis revealed that CD69 augments CCC cell binding to fibronectin (FN) in association with the phosphorylation of multiple cellular signaling molecules including the focal adhesion pathway. Furthermore, CD69 synthesized in CCC cells could facilitate cell survival because the CD69–FN axis can induce epithelial–mesenchymal transition. Experiments with surgically removed tumor samples revealed that CD69 is predominantly expressed in CCC tumor cells compared with other histological subtypes of epithelial ovarian cancer. Overall, our data suggest that cancer cell‐derived CD69 can contribute to CCC progression through FN.
Atypical spindle cell/pleomorphic lipomatous tumour (ASPLT): A report of three FNA cases and comparison with spindle cell/pleomorphic lipoma cytopathology
Authors: Wakely Paul E. 
Published: March 2023

AbstractIntroductionAtypical spindle cell/pleomorphic lipomatous tumour (ASPLT) is an infrequently appreciated benign lipomatous neoplasm newly accepted into the most recent WHO classification of soft tissue tumours.Materials and MethodsOur cytopathology files were searched for examples of ASPLT and spindle cell/pleomorphic lipoma (SCPL) having histopathological verification. Conventional fine needle aspiration (FNA) biopsy smears were performed using standard techniques.ResultsEleven patients including three cases of ASPLT and eight of SCPL (M:F = 4.5:1; age range: 39‐97 years, mean age = 60 years) met the inclusion criteria. FNA biopsy sites included extremity (5, 45%), trunk (3, 27%), and head/neck (3, 27%). All aspirates were from primary neoplasms. FNA diagnoses of ASPLT cases were spindle cell lipomatous neoplasm, fibrotic low‐grade SC neoplasm, and myxoid lipomatous neoplasm. Eight SCPL cases were diagnosed as spindle cell neoplasm (3), spindle cell lipoma (SCL) (1), pleomorphic lipoma (1), suspicious for SCL (1), benign adipose tissue (1), and benign spindle cells and connective tissue (1). Ancillary testing in two ASPLT cases showed positive CD34 and negative MDM2 immunostain in one, and negative FISH results for MDM2 and DDIT3 in another.ConclusionASPLT is a novel lipomatous neoplasm simulating primarily SCPL and atypical lipoma/well‐differentiated liposarcoma. Diligent cytomorphological observation, clinical information, and ancillary testing may allow for its specific recognition using FNA biopsy.
Revisiting the Natural Resource Curse: Backward Linkages for Export Diversification and Structural Economic Transformation
Authors: Savona Maria , Bontadini Filippo 
Published: March 2023

ABSTRACTThis article revisits and empirically tests the conjecture that specialization in natural resource industries (NRI) might not necessarily be a ‘curse’ for developing countries if it generates opportunities for export diversification in backward‐linked sectors à la Hirschman. The article systematizes the evolution of the debate around the NRI ‘curse’. Then it empirically tests whether NRI might represent a sufficient ‘domestic representative demand’ à la Linder to favour diversification into backward‐linked sectors such as knowledge‐intensive business services and high‐tech manufacturing. It focuses on the former and discusses the new opportunities for export diversification led by virtuous pathways of domestic structural change. It finds novel, quantitative empirical support for this conjecture, which complements extant qualitative literature and discusses implications that revisit the NRI curse debate.
Failure to use new breakthrough treatments for epilepsy
Authors: Klein Pavel , Krauss Gregory L. , Steinhoff Bernhard J. , Devinsky Orrin , Sperling Michael R. 
Published: March 2023

AbstractDespite the approval of ~20 additional antiseizure medications (ASMs) since the 1980s, one‐third of epilepsy patients experience seizures despite therapy. Drug‐resistant epilepsy (DRE) is associated with cognitive and psychiatric comorbidities, socioeconomic impairment, injuries, and a 9.3–13.4 times higher mortality rate than in seizure‐free patients. Improved seizure control can reduce morbidity and mortality. Two new ASMs were launched in the United States in 2020: cenobamate for focal epilepsy in adults and fenfluramine for Dravet syndrome (DS). They offer markedly improved efficacy. Cenobamate achieved 21% seizure freedom with the highest dose and decreased tonic–clonic seizures by 93% during maintenance treatment in a randomized clinical trial (RCT). In long‐term, open‐label studies, 10%–36% of patients were seizure‐free for a median duration of ~30–45 months. Fenfluramine treatment in DS reduced convulsive seizure frequency by 56% over placebo at the highest dose, with 8% of patients free of convulsive seizures, and 25% with only one convulsive seizure over 14 weeks. These results were sustained for up to 3 years in open‐label extension studies. Mortality was reduced 5‐fold. These results are superior to all other approved ASMs, placing these two drugs among the most effective antiseizure therapies. The adverse event profiles resemble those of other ASMs. Despite greater efficacy and similar toxicity, these medications are infrequently used. Two years after US market entry, < 5% of either adults with focal DRE or patients with DS were treated with either cenobamate or fenfluramine. We believe this is a failure of our medical system, resulting from limited knowledge about these drugs stemming partly from the separation of academia from industry; restrictions to access created by health care payors, hospitals, and regulatory agencies; and insufficient post‐launch information about the efficacy and safety of these ASMs.
Modeling of senescent cell dynamics predicts a late‐life decrease in cancer incidence
Authors: Bieuville Margaux , Tissot Tazzio , Robert Alexandre , Henry Pierre‐Yves , Pavard Samuel 
Published: March 2023

AbstractCurrent oncogenic theories state that tumors arise from cell lineages that sequentially accumulate (epi)mutations, progressively turning healthy cells into carcinogenic ones. While those models found some empirical support, they are little predictive of intraspecies age‐specific cancer incidence and of interspecies cancer prevalence. Notably, in humans and lab rodents, a deceleration (and sometimes decline) of cancer incidence rate has been found at old ages. Additionally, dominant theoretical models of oncogenesis predict that cancer risk should increase in large and/or long‐lived species, which is not supported by empirical data. Here, we explore the hypothesis that cellular senescence could explain those incongruent empirical patterns. More precisely, we hypothesize that there is a trade‐off between dying of cancer and of (other) ageing‐related causes. This trade‐off between organismal mortality components would be mediated, at the cellular scale, by the accumulation of senescent cells. In this framework, damaged cells can either undergo apoptosis or enter senescence. Apoptotic cells lead to compensatory proliferation, associated with an excess risk of cancer, whereas senescent cell accumulation leads to ageing‐related mortality. To test our framework, we build a deterministic model that first describes how cells get damaged, undergo apoptosis, or enter senescence. We then translate those cellular dynamics into a compound organismal survival metric also integrating life‐history traits. We address four different questions linked to our framework: can cellular senescence be adaptive, do the predictions of our model reflect epidemiological patterns observed among mammal species, what is the effect of species sizes on those answers, and what happens when senescent cells are removed? Importantly, we find that cellular senescence can optimize lifetime reproductive success. Moreover, we find that life‐history traits play an important role in shaping the cellular trade‐offs. Overall, we demonstrate that integrating cellular biology knowledge with eco‐evolutionary principles is crucial to solve parts of the cancer puzzle.
RETRACTED: The energy storage and optimal dispatch supply chain for new energy grids using edge computing and the internet of things
Authors: Liu Jun 
Published: March 2023

AbstractThe intermittent and uncertainty of new energy in the grid connection process affects the overall quality of the grid. To resolve the scattered geographical locations, small individual capacities and poor controllability of distributed energy storage (DES) devices, edge computing is applied in conjunction with aggregate service providers to build an edge computing‐based aggregate model of DES. Regarding its characteristics, the schedulable potential of the energy storage device is analysed through modelling. A multi‐objective scheduling model with multiple parties participating in the subject's behaviour is established using the Internet of Things (IoT) optimization strategy. The simulation example of concrete data further verifies the validity of the model. Results demonstrate that the edge computing‐based aggregate model of DES effectively reduces the calculation load's peak‐valley load and reduces the wind power abandonment. In the meantime, the multiple starts and stops of the thermal power unit reduce the operation cost of the unit. The multi‐objective dispatch model can reduce the opportunity cost and payment of DES effectively. This model achieves load peak reduction and valley filling and reduces the peak dispatch cost of the power grid. The research results can provide some ideas for storing and utilizing the new energy.
Albany K‐Feldspar: A New Pb Isotope Reference Material
Authors: Liebmann Janne , Ware Bryant , Hartnady Michael I.H. , Kirkland Christopher L. , Timms Nicholas E. , Evans Noreen J. 
Published: March 2023

Lead isotopes are a powerful and versatile tool to elucidate fundamental geological problems related to the formation and evolution of continental crust. K‐feldspar is a popular target for Pb isotope measurement as it is prevalent in many rock types and tends to capture the initial Pb isotope composition of its parental magma. We present data for a new Pb isotope reference material: Albany K‐feldspar; as well as updated data for Shap K‐feldspar. Results of Pb double‐spike TIMS for Albany K‐feldspar are 206Pb/204Pb = 16.7872 ± 0.0062, 207Pb/204Pb = 15.5640 ± 0.0056, and 208Pb/204Pb = 36.6600 ± 0.0168 (2s). TIMS measurement results for Shap K‐feldspar indicate two isotopically distinct Pb populations. LA‐MC‐ICP‐MS, with a spatial resolution as high as 15 μm, indicates a homogeneous Pb isotopic composition in Albany K‐feldspar. In accord with previous studies, our results show that scatter in the measured Pb isotope ratios, related to the low natural isotopic abundance of 204Pb, along with the effect of isobaric 204Hg‐204Pb interference, increases at lower count rates. However, the mean Pb isotope ratios measured via LA‐MC‐ICP‐MS using a range of spot sizes are in excellent agreement with TIMS results thus highlighting the feasibility of Pb isotope determination via LA‐MC‐ICP‐MS to access geological information preserved in small crystals, including mineral inclusions.
Using sensemaking as a lens to assess student learning on corporate social responsibility and sustainability
Authors: Preuss Lutz , Fischer Isabel , Luiz John M. 
Published: March 2023

AbstractPrior literature suggests that teaching corporate social responsibility (CSR) and sustainability has led to little development of students' reflexive engagement with the challenges of sustainable development. To shed light on this criticism, we apply sensemaking—as entailing the three stages of scanning for information, interpreting it and identifying alternatives of action—to CSR/sustainability education. Analysing cognitive maps of CSR, drawn by undergraduate finalists from a UK business school, we find that students are able to produce complex cognitive maps in terms of scanning for information; however, cognitive bottlenecks occur at the second and third stages of sensemaking. A key pedagogical challenge is, therefore, to support students in moving beyond scanning towards developing meaning and acting on that basis. By introducing a sensemaking lens, we add to a deeper understanding of the complexities associated with CSR education as it aids (or impedes) critical engagement and action.
Medical librarians and little free libraries: Connecting rural communities to health information
Authors: Grabeel Kelsey Leonard , Wilson Alexandria Quesenberry 
Published: March 2023

AbstractBackgroundConsumer health libraries connect communities to reliable and accurate health information while Little Free Libraries (LFL) provide communities globally with access to free books with a ‘take one leave one’ type policy.ObjectivesTo discuss how medical librarians used already established LFLs as outreach opportunities to provide consumer health books to rural locations in East Tennessee's Appalachia region in the United States.MethodsResearchers reviewed the population's literacy levels, the Index of Medical Underservice scores, and the availability of established LFLs. Twenty‐two established LFL locations were selected and one new LFL was built for an eye clinic. Eleven health books were purchased for each established LFL, and 33 books were purchased for the new LFL.ResultsResearchers went back to each location 5 months after delivery. 90% of the books were taken from the already established LFLs. Ten books were taken from the new LFL.DiscussionUsing already established LFLs is a great opportunity to provide relevant health information to rural communities. The new LFL allowed for a partnership between the library and a rural eye clinic.ConclusionBy distributing health books to already established LFLs, researchers brought relevant health information books to rural and medically underserved communities.
Masstige as a mediator of the relationship between a typical user's image and brand preference
Authors: Kolańska‐Stronka Magdalena , Krasa Paweł 
Published: March 2023

AbstractThe primary research objective was to test the masstige model, which is a mechanism to explain the relationship between symbolic value associated with a brand and brand preference (purchase intention). Using an online individual interview method, respondents rated the masstige, preference, and symbolic characteristics perceived in the image of a typical brand user (TBU), identifying three generalized positive and four negative characteristics. The research was conducted on 20 different brands. The generalized results were analysed using the partial least squares structural equation modeling method. The present study, based on 393 interviews, found that the main TBU characteristics positively associated with brand masstige were two positive dimensions of Sophistication (e.g., elegant), Responsibility (e.g., solid), and one negative dimension of Boorishness (e.g., simpleton), which significantly reduced masstige. In addition, TBU brings the masstige independent part of the brand preference. The results confirm the theoretical relationship between symbolic brand value and masstige, and show that masstige is not the only determinant of brand purchase intention. The results allow for the development/strengthening of the masstige brand statute by targeting TBU characteristics associated with style or responsibility, and reducing associations with neglect, which may translate into increased sales.
Effects of thermosonication on ascorbic acid, polyphenols and antioxidant activity in blackberry juice
Authors: Putsakum Gontorn , Tzima Katerina , Tiwari Brijesh K. , O'Donnell Colm P. , Rai Dilip K. 
Published: March 2023

SummaryLimited research studies exist that assess the impact of thermosonication (TS) processing on antioxidant compounds in blackberry juice. Different combinations of TS parameters (temperature, amplitude power and time) were applied to blackberry juice using a pilot‐scale ultrasonic transducer (UIP500hdT). In low‐temperature treatment, the juice was treated at 10°C and 50% amplitude power for 5 min (10‐50‐5) showed the best retention of ascorbic acid (0.95 mg), total phenolic content (TPC) (459.55 mg GAE), 2, 2‐diphenyl‐1‐picrylhydrazyl (DPPH) (261.34 mg TE) and ferric reducing antioxidant power (FRAP) (604.09 mg TE). Similarly, in high‐temperature treatment, the juices were treated at 70°C and 100% amplitude power for 5 min (70‐100‐5) showed ascorbic acid (1.05 mg), TPC (166.17 mg GAE), DPPH (304.95 mg TE) and FRAP (686.93 mg TE). Both low‐ and high‐temperature treatments showed higher retentions in these attributes than untreated and pasteurised juices. The results were further supported by high retention of predominant polyphenols, namely cyanidin‐3‐O‐glucoside (400.58 and 336.94 mg/100 mL, for 10‐50‐5 and 70‐100‐5, respectively). A similar trend was observed in the contents of cyanidin‐3‐O‐rutinoside, procyanidin dimer B2, 5‐chlorogenic acid, epicatechin and rutin. TS treatment in overall could be a considerable alternative option to be used for antioxidant‐rich blackberry juice production as it has effects on phytochemicals similar to that of pasteurisation.
Plant‐based bioactive peptides: a review of their relevant production strategies, in vivo bioactivities, action mechanisms and bioaccessibility
Authors: Ashaolu Tolulope Joshua , Suttikhana Itthanan 
Published: March 2023

SummaryThe current global trend towards green and environmentally sustainable food sources has favoured plant‐based foods over animal‐based food products. Plants supply most of the required energy for the sustenance of all life forms on earth, and their health‐promoting qualities are mostly derived from their extracts and protein components, which make plant‐based bioactive peptides (BPs) great human health contributors. So many biological activities of these BPs have been reported in vitro but their demonstrated effects may not be the same as those found in in vivo studies. Therefore, this review is aimed at exploring recent literature on the demonstrated in vivo bioactivities of plant‐based BPs. The production of the peptides together with in vivo shreds of evidence are presented and their biological activities like antihypertensive, neuroprotective, and antioxidant effects are exemplified. Furthermore, some of the BP's mechanism of action along with their bioaccessibility inferences are described. Further considerations and concluding remarks on the therapeutic and commercialization potentials of plant‐based BPs are discussed.
Evaluation of honey authenticity in Thailand by analysis of carbon stable isotope ratio using elemental analyser coupled to isotope ratio mass spectrometry and cavity ring‐down spectrometry
Authors: Kamdee Kiattipong , Naksuriyawong Sasiwimon , Uapoonphol Nichtima , Fungklin Ratchai , Esor Jeerawat , Permnamtip Vorapot , Meepho Sang‐arun , Judprasong Kunchit 
Published: March 2023

SummaryIn Thailand, honey is used in a variety of commercial products that are distributed in domestic markets and abroad. As honey in Thailand comes from many locations, it is challenging to control the production quality of commercial products. The main problem commonly found in the honey industry is adulteration with undeclared added sugars. Identification of adulterated honey is crucial for authentication, which can increase consumer confidence on honey purity. In this study, 49 honey samples from beekeepers (natural) and 15 commercial honey producers were collected from different cities across Thailand. They were analysed for stable carbon isotope ratios (expressed as 13C/12C or δ13C and reported in relation to the international reference standard unit Vienna Pee Dee Belemnite, ‰ VPDB) using Elemental Analysis Isotope Ratio Mass Spectrometry (EA‐IRMS) for developing a δ13C database of natural honey and for checking the adulteration of honey. The δ13C values detected in 49 natural honey samples varied from −23.1‰ to −29.1‰ VPDB with an average of −26.8 ± 1.2‰ VPDB. According to the AOAC standard (No. 998.12, 2019), natural honey should have δ13C values lower than −23.5‰ VPDB, with an acceptable difference in δ13C values between honey and the protein extracted from honey up to 1‰. Compared to the standard guideline, 60% of commercial honey samples collected for this study (9 out of 15 samples) were found to contain undeclared added sugars.
Microencapsulation of astaxanthin by ionic gelation: effect of different gelling polymers on the carotenoid load, stability and bioaccessibility
Authors: Vakarelova Martina , Zanoni Francesca , Donà Giulia , Fierri Ilaria , Chignola Roberto , Gorrieri Sara , Zoccatelli Gianni 
Published: March 2023

SummaryAstaxanthin (ASX) is a carotenoid characterised by numerous health‐promoting properties but biased by scarce chemical stability. Our aim was to microencapsulate ASX through ionic gelation to improve its stability and bioaccessibility, evaluating the performance of low‐methoxyl pectin (LMP) and chitosan, besides the most common alginate. Three formulations were tested: 3% pectin (Pec), 3% pectin + chitosan shell (PecChi) and 1.5% alginate—1.5% LMP + chitosan shell. The results showed that chitosan deposited onto PecAlChi and PecChi beads improved particle sphericity and limited oil oxidation during processing. PecAlChi provided the highest encapsulation efficiency (87%) and bioaccessibility (58%). The stability test at 65°C × 24 days showed different polymer‐dependent degradation kinetics, with PecChi providing the highest stability (48%). In conclusion, encapsulation performance strongly depended on the chitosan shell and the gelling polymers. This suggests that tuning the alginate/pectin ratio may lead to the best compromise between stability and bioaccessibility.