bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and psychometric properties of a short version of the Patient Continuity of Care Questionnaire
Authors: Safstrom Emma , Arestedt Kristofer , Hadjistavropoulos Heather D. , Liljeroos Maria , Nordgren Lena , Jaarsma Tiny , Stromberg Anna 
Published: February 2023

AbstractIntroductionHospitalization due to cardiac conditions is increasing worldwide, and follow‐up after hospitalization usually occurs in a different healthcare setting than the one providing treatment during hospitalization. This leads to a risk of fragmented care and increases the need for coordination and continuity of care after hospitalization. Furthermore, international reports highlight the importance of improving continuity of care and state that it is an essential indicator of the quality of care. Patients’ perceptions of continuity of care can be evaluated using the Patient Continuity of Care Questionnaire (PCCQ). However, the original version is extensive and may prove burdensome to complete; therefore, we aimed to develop and evaluate a short version of the PCCQ.MethodsThis was a psychometric validation study. Content validity was evaluated among user groups, including patients (n = 7), healthcare personnel (n = 15), and researchers (n = 7). Based on the results of the content validity and conceptual discussions among the authors, 12 items were included in the short version. Data from patients were collected using a consecutive sampling procedure involving patients 6 weeks after hospitalization due to cardiac conditions. Rasch analysis was used to evaluate the psychometric properties of the short version of the PCCQ.ResultsA total of 1000 patients were included [mean age 72 (SD = 10), 66% males]. The PCCQ‐12 presented a satisfactory overall model fit and a person separation index of 0.79 (Cronbach's α: .91, ordinal α: .94). However, three items presented individual item misfits. No evidence of multidimensionality was found, meaning that a total score can be calculated. A total of four items presented evidence of response dependence but, according to the analysis, this did not seem to affect the measurement properties or reliability of the PCCQ‐12. We found that the first two response options were disordered in all items. However, the reliability remained the same when these response options were amended. In future research, the benefits of the four response options could be evaluated.ConclusionThe PCCQ‐12 has sound psychometric properties and is ready to be used in clinical and research settings to measure patients' perceptions of continuity of care after hospitalization.Patient or Public ContributionPatients, healthcare personnel and researchers were involved in the study because they were invited to select items relevant to the short version of the questionnaire.
Identification and counting of fish targets using adaptive resolution imaging sonar
Authors: Shen Wei , Peng Zhanfei , Zhang Jin 
Published: February 2023

AbstractFish are a critical component of marine biology; therefore, the accurate identification and counting of fish are essential for the objective monitoring and assessment of marine biological resources. High‐frequency adaptive resolution imaging sonar (ARIS) is widely used for underwater object detection and imaging, and it quickly obtains close‐up video of free‐swimming fish in high‐turbidity water environments. Nonetheless, processing the massive data output using imaging sonars remains a major challenge. Here, the authors developed an automatic image‐processing programme that fuses K‐nearest neighbour background subtraction with DeepSort target tracking to automatically track and count fish. The automatic programme was evaluated using four test data sets with different target sizes and observation ranges and differently deployed sonars. According to the results, the approach successfully counted free‐swimming fish targets with an accuracy index of 73% and a completeness index of 70%. Under appropriate conditions, this approach could replace time‐consuming semi‐automatic approaches and improve the efficiency of imaging sonar data processing, while providing technical support for future real‐time data processing.
Corporate social responsibility and bank liquidity creation
Authors: Zheng Chen , Cheung Adrian (Wai Kong) , Zhang Junru , Haider Imran 
Published: February 2023

AbstractUnder the stakeholder theory hypothesis, reputable corporate social responsibility (CSR) banks are expected to attract more loans and deposits, which in turn strengthens their ability to create liquidity. Our findings support this view. Further analyses reveal that the positive effect of CSR on liquidity creation differs depending on bank size, bank capital, and type of financial crisis. In addition, deposit growth, loan growth, lending rate, and funding rate are potential channels through which CSR influences bank liquidity creation. The findings are not driven by an endogeneity issue.
Adverse outcomes associated with opioid prescription by dentists in the Veterans Health Administration: A national cross‐sectional study from 2015 to 2018
Authors: Solanki Pooja A. , Hubbard Colin C. , Poggensee Linda , Evans Charlesnika T. , Suda Katie J. 
Published: February 2023

AbstractObjectivesOpioids prescribed by dentists have been associated with serious adverse events, including opioid‐related overdose and mortality. However, the downstream outcomes of opioids prescribed by dentists to Veterans who are at high risk for opioid misuse and overdose have yet to be determined.MethodsThis was a national cross‐sectional analysis of opioids associated with dental visits within the Veterans Health Administration from 2015 to 2018. Overprescribing was defined per guidelines as >120 morphine milligram equivalents (MME) or >3 days supply. The association of dental visit and patient characteristics was modeled separately for opioid‐related poisoning and all‐cause mortality using logistic regression.ResultsOf 137,273 Veterans prescribed an opioid by a dentist, 0.1% and 1.1% were associated with opioid‐related poisoning and mortality, respectively. There was no difference in opioid poisoning within 6 months for Veterans with opioid prescriptions >120 MME (aOR = 1.25 [CI: 0.89–1.78]), but poisoning decreased in Veterans prescribed opioids >3‐days supply (aOR = 0.68 [CI: 0.49–0.96]). However, Veterans with opioids >120 MME were associated with higher odds of mortality within 6 months (aOR = 1.17 [95% CI: 1.05–1.32]) while there was no difference in prescriptions >3‐days supply (aOR = 1.12 [CI: 0.99–1.25]).ConclusionSerious opioid‐related adverse events were rare in Veterans and lower than other reports in the literature. Since nonopioid analgesics have superior efficacy for the treatment of acute dental pain, prescribing opioid alternatives may decrease opioid‐related poisoning. Strategies for dentists to identify patients at high risk should be incorporated into the dental record.
Diagnostic features of type II fibrinoid leukodystrophy (Alexander disease) in a juvenile Beagle dog
Authors: Vandenberghe Hélène , Baiker Kerstin , Nye George , Escauriaza Leticia , Roberts Emma , Granger Nicolas , Reeve Lizzie 
Published: February 2023

AbstractA 3‐month‐old female entire Beagle presented with a progressive history of caudotentorial encephalopathy. Reactive encephalopathies were ruled out and tests for the most common infectious diseases agents were negative. Magnetic resonance imaging of the brain using a 1.5 Tesla scanner showed diffuse, bilateral, T2‐weighted and T2‐weighted‐FLAIR hyperintense, T1‐weighted hypointense, noncontrast‐enhancing lesions involving the white matter of the cerebellum, brainstem, spinal cord, and forebrain to a lesser extent. There was cerebellar enlargement. Abnormalities were not detected on cerebrospinal fluid examination. Given the progressive nature of the disease and suspected poor prognosis the dog was euthanized. Histopathological analysis of the brain was consistent with fibrinoid leukodystrophy, also known as Alexander disease. Based on the classification used in humans, this is a description of MRI of a case of type II Alexander disease in veterinary medicine, with characteristics different to other described leukoencephalopathies in dogs.
Romantic objects, Victorian collections: Scribal relics and the authorial body
Authors: Sommer Tim 
Published: February 2023

AbstractOver the course of the nineteenth century, literary manuscripts came to be seen as tangible evidence of the creative process and as a key to the personality of the author. The material traces of writing were understood to outlive their creators and promise to resurrect the authorial body through the magic of the relic. This article reconstructs how authorial script gradually transformed into a collectible object pursued as a memento and a commodity. Letters, drafts, and fair copies by major modern writers found their way into the collections of British aristocrats and American industrialists at the same time that hunting for literary autographs diversified into a middle‐class pursuit. Surveying recent scholarship on nineteenth‐century collecting and material culture, the essay offers a condensed cultural history of the literary manuscript as a collectible and draws attention to how collectors and collecting feature in fictional texts of the period. It focuses on the artefactual mobility and custodial afterlives of Romantic papers in Victorian literature and culture, exploring a form of collecting which crossed boundaries between periods and national literary traditions.
Increase of liver stiffness and altered bile acid metabolism after triple CFTR modulator initiation in children and young adults with cystic fibrosis
Authors: Schnell Alexander , Jüngert Jörg , Klett Daniel , Hober Hannah , Kaiser Natalie , Ruppel Renate , Geppert Annika , Tremel Christina , Sobel Julia , Plattner Erika , Schmitt‐Grohé Sabina , Zirlik Sabine , Strobel Deike , Neurath Markus F. , Knieling Ferdinand , Rauh Manfred , Woelfle Joachim , Hoerning André , Regensburger Adrian P. 
Published: February 2023

AbstractBackgroundNovel cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies (elexacaftor/tezacaftor/ivacaftor—ETI) promise clinically significant and sustained improvements for patients with cystic fibrosis (CF). In this study, we investigated the impact of ETI therapy on liver stiffness and bile acid metabolism in a cohort of children and young adults with CF.MethodsA prospective observational study (NCT05576324) was conducted from September 2020 to November 2021 enrolling CF patients naive to ETI. Standard laboratory chemistry, sweat test, lung function, share wave velocity (SWV) derived by acoustic radiation force impulse imaging (ARFI) and serum bile acid profiles were assessed before and 6 months after induction of ETI therapy.ResultsA total of 20 patients (10 aged <20 years) completed the study. While lung function and BMI improved after ETI therapy, ARFI SWV increased in CF patients <20 years of age (from 1.27 to 1.43 m/s, p = 0.023). Bile acid (BA) profiles revealed a decrease in unconjugated (5.75 vs 1.46, p = 0.007) and increase in glycine‐conjugated derivatives (GCDCA) (4.79 vs 6.64 p = 0.016). There was a positive correlation between ARFI SWV values and GCDCA (r = 0.80, p < 0.0001). Glycine‐conjugated BA provided high diagnostic accuracy to predict increased ARFI measurements (AUC 0.90) and clinical (Colombo) CFLD grading (AUC 0.97).ConclusionsARFI SWV and bile acid profiles provide evidence for early increase in liver stiffness and altered bile acid metabolism in young CF patients after initiation of ETI and may serve as synergistic measures for detection of hepatic complications during ETI therapy.
Potential therapies for acute‐on‐chronic liver failure
Authors: Morrison Maura A. , Artru Florent , Trovato Francesca M. , Triantafyllou Evangelos , McPhail Mark J. 
Published: February 2023

AbstractAcute‐on‐chronic liver failure (ACLF) is a syndrome that develops in approximately 30% of patients hospitalised with cirrhosis and is characterised by an acute decompensation of liver function associated with extra‐hepatic organ failures and a high short‐term mortality. At present, no specific therapies are available for ACLF, and current management is limited to treatment of the precipitating event and organ support. Given the high prevalence and high mortality of this severe liver disease, there is an urgent need for targeted treatments. There is increasing evidence of the important role played by systemic inflammation and immune dysfunction in the pathophysiology of ACLF and a better understanding of these immune processes is resulting in new therapeutic targets. The aim of this review is to present an overview of ongoing studies of potentially promising therapies and how they could be utilised in the management of ACLF.
Abundance, perceptions and utilizations of termite mounds in Cambodia
Authors: Muon Ratha , Lai Chenda , Hervé Vincent , Zaiss Rainer , Chassagne François , Bureau‐Point Eve , Marchand Sébastien , Audibert Martine , Berger Jacques , Wieringa Frank , Savouré Arnould , Sok Kimchhin , Meunier Jean‐Dominique , Ann Vannak , Jouquet Pascal 
Published: February 2023

AbstractIn the Lower Mekong Basin, paddy fields often appear as mosaics, with soil mounds covered by trees or other plants in a spotty distribution. These soil mounds are commonly named termite ‘lenticular mounds’ because termite bioturbation is considered to be at their origin. Termite mounds host a large diversity of animals and plants, increasing landscape patchiness. Because the preservation of these islands of biodiversity is threatened by modern agricultural practices, the aim of this study was to quantify their abundance and the services they provide to the local population. The abundance of mounds and their use by the population were quantified in a catchment in Cambodia. We found that mounds density reached ~2 mounds ha−1. Interviews carried out within the catchment showed that most of the interviewees used mounds for increasing the fertility of their field and for the cultivation of rice and other plants (e.g. sponge gourd and pumpkin). In addition to their potential to increase plant productivity, the survey revealed that animals (rats and snakes), mushrooms and 13 plant species found on or in mounds were consumed by the population. In addition to potentially contributing to an increase in food diversity, mounds also impacted farmers' health by allowing access to 20 medicinal plant species and indirectly via a reduction in pesticide use. In conclusion, this study is the first attempt to quantify the large number of services provided by termite mounds in Cambodia. This increase in the knowledge of the diversity of environmental and socioeconomic services provided by termite mounds is likely to contribute to their preservation and provide a basis for the sustainable management of biodiversity in paddy fields in the Lower Mekong Basin region.
Cholinergic collaterals arising from noradrenergic sympathetic neurons in mice
Authors: Clyburn Courtney , Li Ming‐Hua , Ingram Susan L. , Andresen Michael C. , Habecker Beth A. 
Published: February 2023

AbstractThe sympathetic nervous system vitally regulates autonomic functions, including cardiac activity. Postganglionic neurons of the sympathetic chain ganglia relay signals from the central nervous system to autonomic peripheral targets. Disrupting this flow of information often dysregulates organ function and leads to poor health outcomes. Despite the importance of these sympathetic neurons, fundamental aspects of the neurocircuitry within peripheral ganglia remain poorly understood. Conventionally, simple monosynaptic cholinergic pathways from preganglionic neurons are thought to activate postganglionic sympathetic neurons. However, early studies suggested more complex neurocircuits may be present within sympathetic ganglia. The present study recorded synaptic responses in sympathetic stellate ganglia neurons following electrical activation of the pre‐ and postganglionic nerve trunks and used genetic strategies to assess the presence of collateral projections between postganglionic neurons of the stellate ganglia. Orthograde activation of the preganglionic nerve trunk, T‐2, uncovered high jitter synaptic latencies consistent with polysynaptic connections. Pharmacological inhibition of nicotinic acetylcholine receptors with hexamethonium blocked all synaptic events. To confirm that high jitter, polysynaptic events were due to the presence of cholinergic collaterals from postganglionic neurons within the stellate ganglion, we knocked out choline acetyltransferase in adult noradrenergic neurons. This genetic knockout eliminated orthograde high jitter synaptic events and EPSCs evoked by retrograde activation. These findings suggest that cholinergic collateral projections arise from noradrenergic neurons within sympathetic ganglia. Identifying the contributions of collateral excitation to normal physiology and pathophysiology is an important area of future study and may offer novel therapeutic targets for the treatment of autonomic imbalance.
imageKey points
Electrical stimulation of a preganglionic nerve trunk evoked fast synaptic transmission in stellate ganglion neurons with low and high jitter latencies.
Retrograde stimulation of a postganglionic nerve trunk evoked direct, all‐or‐none action currents and delayed nicotinic EPSCs indistinguishable from orthogradely‐evoked EPSCs in stellate neurons.
Nicotinic acetylcholine receptor blockade prevented all spontaneous and evoked synaptic activity.
Knockout of acetylcholine production in noradrenergic neurons eliminated all retrogradely‐evoked EPSCs but did not change retrograde action currents, indicating that noradrenergic neurons have cholinergic collaterals connecting neurons within the stellate ganglion.
Interventions in primary and community care to reduce urgent paediatric hospital admissions: systematic review
Authors: Dick Smita , MacRae Clare , McFaul Claire , Wilson Philip , Turner Stephen W 
Published: February 2023

BackgroundThere has been a rise in urgent paediatric hospital admissions and interventions to address this are required.ObjectiveTo systemically review the literature describing community (or non-hospital)-based interventions designed to reduce emergency department (ED) visits or urgent hospital admissions.Data sourcesMEDLINE, Embase, OVIS SP, PsycINFO, Science Citation Index Expanded/ISI Web of Science (1981–present), the Cochrane Library database and the Database of Abstracts of Reviews of Effectiveness.Study eligibility criteriaRandomised controlled trials (RCTs) and before-and-after studies.ParticipantsIndividuals aged <16 years.Study appraisal and synthesis methodsPapers were independently reviewed by two researchers. Data extraction and the Critical Appraisals Skills Programme checklist was completed (for risk of bias assessment).ResultsSeven studies were identified. Three studies were RCTs, three were a comparison between non-randomised groups and one was a before-and-after study. Interventions were reconfiguration of staff roles (two papers), telemedicine (three papers), pathways of urgent care (one paper) and point-of-care testing (one paper). Reconfiguration of staff roles resulted in reduction in ED visits in one study (with a commensurate increase in general practitioner visits) but increased hospital admissions from ED in a second. Telemedicine was associated with a reduction in children’s admissions in one study and reduced ED admissions in two further studies. Interventions with pathways of care and point-of-care testing did not impact either ED visits or urgent admissions.Conclusions and implicationsNew out-of-hospital models of urgent care for children need to be introduced and evaluated without delay.PROSPERO registration numberCRD42021274374.
Effectiveness of a warm-up programme to reduce injuries in youth volleyball players: a quasi-experiment
Authors: Verhagen Evert , Vriend Ingrid , Gouttebarge Vincent , Kemler Ellen , de Wit Jacqueline , Zomerdijk Daniel , Nauta Joske 
Published: February 2023

ObjectivesTo establish the effectiveness of the ‘VolleyVeilig’ programme on reducing injury rate, injury burden and injury severity in youth volleyball players.MethodsWe conducted a quasi-experimental prospective study over one season of youth volleyball. After randomisation by competition region, we instructed 31 control teams (236 children, average age 12.58±1.66) to use their usual warm-up routine. The ‘VolleyVeilig’ programme was provided to 35 intervention teams (282 children, average age 12.90±1.59). This programme had to be used during each warm-up before training sessions and matches. We sent a weekly survey to all coaches, collecting data on each player’s volleyball exposure and injuries sustained. Multilevel analyses estimated differences in injury rates and burden between both groups, and we used non-parametric bootstrapping to compare the differences in injury numbers and injury severity.ResultsWe found an overall reduction in injury rates of 30% for intervention teams (HR 0.72; 95% CI 0.39 to 1.33). Detailed analyses revealed differences for acute (HR 0.58; 95% CI 0.34 to 0.97) and upper extremity injuries (HR 0.41; 95% CI 0.20 to 0.83). Compared with control teams, the intervention teams had a relative injury burden of 0.39 (95% CI 0.30 to 0.52) and a relative injury severity of 0.49 (95% CI 0.03 to 0.95). Only 44% of teams fully adhered to the intervention.ConclusionWe established that the ‘VolleyVeilig’ programme was associated with reduced acute and upper extremity injury rates and lower injury burden and severity in youth volleyball players. While we advise implementation of the programme, programme updates to improve adherence are needed.
The Role of Radiotherapy for Patients with Unresectable Locally Advanced Breast Cancer following Neoadjuvant Systemic Therapy
Authors: Wang Xiaofang , Meng Jin , Zhang Xiaomeng , Zhang Li , Chen Xingxing , Yang Zhaozhi , Mei Xin , Yu Xiaoli , Zhang Zhen , Shao Zhimin , Liu Guangyu , Guo Xiaomao , Ma Jinli 
Published: February 2023

Background. For locally advanced breast cancer (LABC) patients who remained unresectable after neoadjuvant systemic therapy (NST), radiotherapy (RT) is considered as an approach for tumor downstaging. In this study, we attempted to discuss the value of RT for patients with unresectable or progressive disease in the breast and/or regional nodes following NST. Methods. Between January 2013 and November 2020, the data for 71 patients with chemo-refractory LABC or de novo bone-only metastasis stage IV BC who received locoregional RT with or without surgical resection were retrospectively analyzed. Factors associated with tumor complete response (CR) were recognized using logistic regression. Locoregional progression-free survival (LRPFS) and progression-free survival (PFS) were calculated using the Kaplan–Meier method. The Cox regression model was applied to recognize the recurrence risk factors. Results. After RT, 11 patients (15.5%) achieved total cCR. Triple-negative subtype (TNBC) was associated with a lower total cCR rate compared with other subtypes (

p

= 0.033). 26 patients proceeded to surgery, and the operability rate was 36.6%. 1-year LRPFS and PFS were 79.0% and 58.0%, respectively, for the entire cohort. Surgical cases had an improved 1-year LRPFS (

p

= 0.015), but not 1-year PFS (

p

= 0.057), compared with definitive RT cases. Non-any cCR was the most prominent predictor of a shorter LRPFS (

p

< 0.001) and PFS (

p

= 0.002) in the multivariate analysis. Higher TNM stage showed a trend toward a shorter LRPFS time (

p

= 0.058), and TNBC (

p

= 0.061) showed a trend toward a shorter PFS interval. Conclusions. This study demonstrated that RT was an effective tumor downstaging option for chemo-refractory LABC. For patients with favorable tumor regression, surgery following RT might bring survival benefits.