bluuebunny/crossref_metadata_2025_split huggingface dataset:
CarboCell combinatorial immunotherapy orchestrates curative anticancer immune activation of the tumor microenvironment
Authors: Jensen Sophie , Serrano-Chávez Elizabeth , Halldórsdóttir Hólmfridur , Engel Trine , Jørgensen Jennifer , Kostrikov Serhii , Scheeper Marouschka , Ringgaard Lars , Bruun Linda , Stavnsbjerg Camilla , Jæhger Ditte , Christensen Esben , Bak Martin , Thuroczy Julianna , Balogh Lajos , Jensen Andreas , Melander Fredrik , Kjaer Andreas , Henriksen Jonas , Hansen Anders , Andresen Thomas 
Published: February 2023

Abstract

Cancer curing immune responses against heterogeneous solid cancers require that a coordinated immune activation is initiated in the antigen avid but immunosuppressive tumor microenvironment (TME). The plastic, immunosuppressive TME, and the poor systemic tolerability of immune activating drugs are, however, fundamental barriers to generating curative anticancer immune responses. Here, we introduce the CarboCell technology to overcome these barriers by forming a sustained drug release depot at the injection site that provides high payloads of immune stimulatory drugs selectively within the TME. The CarboCell thereby induces a hot spot for immune cell training and polarization and further drives and maintains the tumor-draining lymph nodes in an anticancer and immune activated state. Mechanistically, this transforms cancerous tissues to allow infiltration of T cells, consequently generating systemic anticancer immunoreactivity. The CarboCell technology can release multiple small molecule drugs - each with tailored release profiles - rendering it active across the broad composition of TME backgrounds. In the current study, impressive therapeutic performance is presented for a dual-drug CarboCell providing sustained release of a Toll-like receptor 7/8 agonist and a transforming growth factor-β inhibitor. CarboCell can be injected through standard clinical thin-needle technologies. Its inherent magnetic resonance imaging and ultrasound visibility, and optional radiographic contrast, make it possible to validate and plan CarboCell injections across clinical imaging modalities. These features, in combination with attractive injection intervals, secure optimal patient compliance and open new possibilities for intratumoral immunotherapy accurately across basically all anatomical locations.
Impact of Temperature on the Rheological Properties with Shear Stress limit of Iron Oxide Nanoparticle Modified Drilling Fluid of Dibella, Oil Field
Authors: mahamadou abdoulaye seyni , ALEHEMER EINAS MOHAMMED SLAMA 
Published: February 2023

Abstract
In eastern Niger, a very complex rift system, whose sediment superfluity varies in age from Upper Jurassic to Lower Tertiary, has real and sure petroleum potential. Basin rocks are essentially Cretaceous to Eocene sandstones, arising from Cretaceous marine shales and Oligocene lacustrine shale; The Paleogene lacustrine mudstone is one of the most important sets of source rocks in the Termit Basin. The Agadem Oil Field in Niger holds distinct types of reservoirs and several sets of oil layers. There are large differences in the physical properties of the reservoir, the pressure system, and the fluid properties in the different layers, and the contradiction of inter-layer interference is large, which requires layered production. Micro and nanotechnologies have already made a particular contribution to technological progress in several industries, including electronics, biomedical, pharmaceutical, materials and manufacturing, aerospace, photography, and most recently energy. Micro and nanotechnologies have the potential to introduce agitating mutations in various uses of the oil and gas industries such as exploration, drilling, production, refining, and distribution. nanosensors could provide more precise and concise information on smart reservoirs and fluids for enhanced oil recovery and drilling. These experiments carried out in the laboratory aim to the influence of iron oxide nanoparticles and shear rates on the shear stress of the drilling fluid. We find that the plastic viscosity (PV), threshold (YP) and freeze resistance of the water-based mud-water system (WBM) lessen with increasing temperature until failure. of the mud system. It is therefore mandatory to continue our work to stabilize the failures of the sludge system using nanoparticles. In this study, six water-based sludge samples were prepared at different concentrations (0.5 g, 1 g, 1.5 g, 2 g, 2.5 g, 3 g) of iron oxide Fe2O3, the results showed that a diligent rheological property was completed with an optimal nanoparticle concentration of 2.5 g of iron oxide at temperatures of 300OF and a pressure of 10.00 psi, we achieved diligent rheological characteristics by 14.78%, 9.57%, 14.78% and 16.59% reduction in the strength of freezing PV, YP, 10 seconds and 10 minutes.
Structural variation across 138,134 samples in the TOPMed consortium
Authors: Jun Goo , English Adam , Metcalf Ginger , Yang Jianzhi , Chaisson Mark , Pankratz Nathan , Menon Vipin , Salerno William , Krasheninina Olga , Smith Albert , Lane John , Blackwell Thomas , Kang Hyun Min , Salvi Sejal , Meng Qingchang , Shen Hua , Pasham Divya , Bhamidipati Sravya , Kottapalli Kavya , Arnett Donna , Ashley-Koch Allison , Auer Paul , Beutel KAthleen , Bis Joshua , Blangero John , Bowden Donald , Brody Jennifer , Cade Brian , Chen Yii-Der Ida , Cho Michael , Curran Joanne , Fornage Myriam , Frredman Barry , Fingerlin Tasha , Gelb Bruce , Hou Lifang , Hung Yi-Jen , Kane John P , Kaplan Robert , Kim Wonji , Loos Ruth , Marcus Gregory , Mathias Rasika , McGarvey Stephen , Montgomery Courtney , Naseri Take , Nouraie Seyed , Preuss Michael , Palmer Nicholette , Peyser Patricia , Raffield Laura , Ratan Aakrosh , Redline Susan , Reupena Muagututia , Rotter Jerome , Rich Stephen , Rienstra Michiel , Ruczinski Ingo , Sankaran Vijay , Schwartz David , Seidman Christine , Seidman Jonathan , Silverman Edwin , Smith Jennifer , Stilp Adrienne , Taylor Kent , Telen Marilyn , Weiss Scott , Williams L. Keoki , Wu Baojun , Yanek Lisa , Zhang Yingze , Lasky-Su Jessica , Gingras Marie-Claude , Dutcher Susan , Eichler Evan , Gabriel Stacey , Germer Soren , Kim Ryan , Martinez Karine , Nickerson Deborah , Luo James , Reiner Alexander , Gibbs Richard , Boerwinkle Eric , Abecasis Goncaol , Sedlazeck Fritz 
Published: February 2023

Abstract
Ever larger Structural Variant (SV) catalogs highlighting the diversity within and between populations help researchers better understand the links between SVs and disease. The identification of SVs from DNA sequence data is non-trivial and requires a balance between comprehensiveness and precision. Here we present a catalog of 355,667 SVs (59.34% novel) across autosomes and the X chromosome (50bp+) from 138,134 individuals in the diverse TOPMed consortium. We describe our methodologies for SV inference resulting in high variant quality and >90% allele concordance compared to long-read de-novo assemblies of well-characterized control samples. We demonstrate utility through significant associations between SVs and important various cardio-metabolic and hematologic traits. We have identified 690 SV hotspots and deserts and those that potentially impact the regulation of medically relevant genes. This catalog characterizes SVs across multiple populations and will serve as a valuable tool to understand the impact of SV on disease development and progression.
Shared genetic etiology and causal relationships among NAFLD, obesity and glycemic traits: A large-scale genome-wide cross-trait analysis.
Authors: Wang Xinpei , Song Jieyun , Wang Youxin , Wang Hai-Jun , Jia Jinzhu , Wang Hui 
Published: February 2023

Abstract
Background: The shared genetic etiology among nonalcoholic fatty liver disease (NAFLD), overweight/obesity and type 2 diabetes (T2D), three closely related diseases, has not yet been thoroughly investigated. We aimed to explore the shared genetic etiology and causal relationships between the 3 diseases.
Methods: Using public large-scale genome-wide association study (GWAS) data, the shared genetics between NAFLD (case=8,434, control=770,180) and 5 obesity traits (n= 224,459~700,000)/5 glycemic traits (n=281,416~659,316) were conducted with linkage disequilibrium score regression and cross-phenotype association (CPASSOC). The causal associations were explored with Mendelian Randomization (MR).
Results: We revealed 20 shared loci between NAFLD and obesity traits and 10 loci between NAFLD and glycemic traits (P<5×10-8). Among them, 10 loci were not reported previously in any association with NAFLD/obesity/glycemic traits. Ten out of 11 reported variants [after removing the high LD (r2≥0.8)] were missense variants. Most shared loci with known function were involved in the metabolism of lipids. Positive causal effects of obesity traits (particularly abdominal obesity) on NAFLD were detected, while NAFLD negatively impacted general obesity (BMI) and positively impacted abdominal obesity. Intriguingly, only fast insulin had a positive causal association with NAFLD and vice versa.
Conclusions: Our study suggests that NAFLD, obesity and glycemic traits have shared genetic etiologies, particularly in the metabolism of lipids. The present work advances our understanding of the genetic basis of these 3 closely related diseases and sheds light on a new method for drug design.
Tumor dosimetry in the presence of background activity – a phantom study using 177Lu.
Authors: Staanum Peter Frøhlich 
Published: February 2023

Abstract
Background: Image-based tumor dosimetry after radionuclide therapy, using the isotope 177Lu, finds application e.g. for tumor to organ dose comparison and for dose response evaluation. When the tumor extent is not much larger than the image resolution, and when 177Lu is found in nearby organs or other tumors, an accurate determination of tumor dose is particularly challenging.
Here a quantitative evaluation of three different methods for determining the 177Lu activity concentration in a phantom is performed, and the dependence on a variety of parameters is described. The phantom (NEMA IEC body phantom) has spheres of different size in a background volume, and sphere-to-background 177Lu activity concentration ratios of infinity, 9.5, 5.0 and 2.7 are applied.
Results: The determined activity concentration varies significantly with sphere size, sphere-to-background ratio, SPECT reconstruction method and method for determining the concentration. Criteria are proposed for which a reasonably stable and accurate determination of activity concentration can be obtained for application in tumor dosimetry even in the presence of background activity.
Conclusions: Tumor dosimetry to a reasonable accuracy is feasible in the presence of background activity, provided certain criteria are followed for selecting tumors for dosimetry analysis.
Decoding deceipt: EEG signatures of lying behavior under spontaneous versus instructed lying and truth-telling in a two-player game
Authors: Chen Yiyu , Fazli Siamac , Wallraven Christian 
Published: February 2023

Abstract
Background Is it possible to decode lying behavior from neural signatures of the electroencephalography (EEG)? Existing studies on this topic have methodological limitations: tasks lack the incentive to lie, the act of lying is confounded with memory recollection, there is no sufficient distinction between instructed versus spontaneous decisions, and participants' risk-taking tendency is not controlled for. To address these limitations, we introduce a novel interactive, two-player game, where successful lying is incentivized in the reward scheme and that has both instructed and spontaneous conditions for participants matched by risk-taking tendency.
Methods 24 participants were paired in the game according to their risk-taking tendency scores and measured using 32-channel EEG. Our multi-modal EEG analysis includes event-related potential (ERP), event-related spectral (ERS), and deep-learning-based single-trial decoding.
Results In ERP, two early components (P200 and N200) distinguished instructed truth-telling from other conditions, with a late component (N300) separating instructed lies from spontaneous conditions. Moreover, a late positive potential was indicative of spontaneous lying versus spontaneous truth-telling and was correlated with participants' risk-taking tendencies. In ERS, alpha and low beta were found to discriminate conditions. Importantly, we observed robust single-trial decoding performance under different conditions for the 1D-CNN. A gradient-based analysis further identified significant time-periods compatible with the ERP results from the classifier.
Conclusions Our study represents the first effort to analyze EEG data not only through statistical properties but also with out-of-sample, deep-learning-based classification to decode deceit in the context of an iterative, game-theoretic experiment.
Correlation between abnormal cellular immune and changes of magnetic resonance spectroscopy in patients with Alzheimer's disease
Authors: Zeng Hongmei , Zhang Qifang , Liu Lijie , Deng Feifei , Han Huabo , Meng Fuxue , Bai Hua 
Published: February 2023

Abstract

Neuroinflammation in brain and immune-related cells in peripheral blood may be involved in the occurrence and development of Alzheimer’s disease (AD). This study aims to explore the correlation between the abnormality of cellular immune function and the changes of neurotransmitters. 32 AD cases and 40 Vascular dementia (VD ) cases were studied. Lymphocyte subsets in plasma were detected by flow cytometry. IL-1β and caspase-1 were detected by ELISA. NLRP3 was detected by Western blot. N-cetyl aspartate (NAA), creatine (Cr), choline (Cho), and inositol (MI) equivalence in bilateral hippocampi of patients were examined by MRS. Single-factor correlation analysis was conducted between NAA/Cr or MI/Cr and the proportion of T lymphocyte subsets or NK cell subsets. The proportion of T lymphocyte subsets in the AD group was significantly decreased than that in the non-dementia elderly control (UDE) group (P < 0.01). Caspase-1 and IL-1β protein in the AD group were significantly increased. NLRP3 protein in the AD group were significantly increase. In terms of NAA/Cr ratio or NAA/Cr ratio in the AD group was lower than that in UDE group. The NAA/Cr ratio was significantly positively correlated with the MMSE score (r = 0.81, P < 0.01). There was a significant positive correlation between NAA/Cr ratio and T lymphocyte ratio. The NAA/Cr ratio was significantly negatively correlated with the proportion of NK cells in the blood. There was a significant negative correlation between the MI/Cr ratio and the ratio of T cells in the blood. Abnormal neuroimmune function may be involved in the pathogenesis of AD and affect the metabolism of neurotransmitters such as aspartic acid and inositol in the brain of AD patients.
Tannic acid-poly ethyleneimine magnetic nanoparticles: an efficient and recyclable catalyst for green synthesis of 2,3-dihydroquinazole derivatives
Authors: Zirakjou Sahar , Dekamin Mohammad G. , Valiey Ehsan , Dohendou Mohammad 
Published: February 2023

Abstract
A novel and recyclable catalytic system was prepared by linking polyethyleneimine (PEI) to tannic acid (TA) using 1,3-dibromopropane, as a cross-linker, to afford (TA-PEI) composite during a convenient and inexpensive procedure. Moreover, to increase the efficacy of the catalyst and to reduce the reaction time, magnetization and sulfonation of the prepared nano-catalyst have been properly performed to afford the final TA/PEI/magnetic/sulfonated (TPMS) supramolecular heterogeneous nonmagnetic composite. The TPMS catalytic system was characterized by various spectrometric and analytical techniques including Fourier transform infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FE-SEM), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX) and vibrating sample magnetometer (VSM). Furthermore, the heterogeneous TPMS nanocomposite catalytic sytem demonstrated excellent catalytic activity for the one-pot synthesis of 2,3-dihydroquinazole derivatives through a green and sustainable procedure to afford desired products in good to excellent yields. The supramolecular TPMS catalytic system have several advantages including easy separation, nature-friendly, eco-friendly, cost-effective, and reduced reaction time. The reusability of TPMS nanocatalyst was also investigated and the results showed that there is not any significant decrease in the efficiency of the catalyst after five reaction cycles.
Determinants of congenital anomalies in neonates admitted to public hospitals in Eastern Ethiopia: A Case-Control study
Authors: Belama Nano , Desalew Assefa , Lami Magarsa , Roba Kedir Teji 
Published: February 2023

Abstract

Background
More than 8 million newborns are born with congenital anomalies worldwide, and 3.2 million children are disabled as a result of congenital anomalies. Despite the high prevalence of congenital anomalies in Ethiopia, research on their determinants of congenital anomalies in newborns is limited, particularly in eastern Ethiopia.
Methods
A facility-based unmatched case-control study of 387 participants (129 cases and 258 controls) born in public hospitals in the Harari region and the Dire Dawa administration was conducted. An interviewer-administered structured questionnaire and a review of medical records were used to collect data. The determinants of congenital malformations were studied using a multivariate logistic regression analysis. Multivariable logistic regression analysis was used to determine a significant association with a p-value of 0.05.
Results
According to this study, the most common type of congenital anomaly was nervous system anomalies (84.6%), followed by musculoskeletal system anomalies (16.4%). In multivariable logistic regression analysis, neonates from anemic mothers (AOR: 4.37, 95% CI: 2.48–7.69), maternal alcohol consumption during index pregnancy (AOR: 4.01, 95% CI: 1.88–8.54), rural residence (AOR: 1.73, 95% CI: 1.04–2.85), and antenatal care visits (AOR: 0.43, 95% CI: 0.22–0.84) were significant predictors of congenital anomalies.
Conclusion
Maternal anemia, substance use during pregnancy, antenatal care visits, and rural residence were risk factors for congenital anomalies. Reducing the burden of congenital anomalies requires addressing modifiable factors such as maternal anemia, alcohol consumption, chewing Khat, and increasing antenatal care follow-up.
INS-YOLOX： Improved YOLOX for Detecting Insulator Defects
Authors: Li Cen , Wang Chensheng , Yang Guang , Dong Liang , Zhang Zhiyue 
Published: February 2023

Abstract

One of the methods for detecting transmission line damage is image defect detection of transmission line insulators. The industrialization of image defect detection has made the construction of detection algorithm models with quick detection times, high accuracy, and compact models into a fundamental issue. In order to efficiently address the issues of accuracy and speed of insulator defect detection, this work offers an enhanced version of the INS-YOLOX model based on a one-stage detector. The history of the insulator defect is complicated, as are its potential targets. The target is tiny, and there is little distinction between the images of a faulty insulator and a lossless insulator. The first step is the proposal of a new loss function, L-SIoU, which not only considers the vector Angle between necessary regressions, redefines the penalty index, but also considers the influence of the aspect ratio between the prediction box and regression box, which increases reasoning accuracy and speed. The detection precision of the imbalanced data set was then increased by switching from BCE Loss to Varifocal Loss. In order to improve the feature point extraction, the CBAM attention mechanism was lastly integrated to the Decoupled Head structure. Additionally, INS-YOLOX adds the SGD optimizer and successfully optimizes the model's training parameters. A total of 6227 photos were gathered as a data set to evaluate the model's validity. The test results demonstrate the real-time detection capabilities of INS-YOLOX. The final map, at 83.2%, is 11.1% higher than the benchmark model of YOLOX-tiny and 6% higher than the most recent Yolov7. This represents a major accomplishment.
Prognostic significance of lymph node count in D’Amico high risk prostate cancer with different lymph node metastasis risks after radical prostatectomy
Authors: Li Xintao , Gao Yu , Liu Yanzhong , Niu Shaoxi , Li Jianye , Zhang Xu , Yang Minghui 
Published: February 2023

Abstract
Extended pelvic lymph node dissection (PLND) is recommended in high risk prostate cancer (PCa). We aim to identify the prognostic significance of removed lymph node count (RLNC) for patients with D’Amico high risk PCa and different lymph node metastasis risk (LNMR). We identified surgically treated D’Amico high risk PCa patients with the Surveillance, Epidemiology, and End Result (SEER) Plus database (2004-2019). Multivariable logistic regression model was established to predict lymph node metastasis risk (LNMR) in patients with RLNC over 6. Multivariable Cox regression analysis were used to assess the impact of RLNC on cancer-specific survival (CSS) and overall survival (OS). A total of 96875 patients were identified. 5261 patients (5.43%) had LN metastasis. The median and 75th percentile RLNC was 6 and 11. LNMR was calculated for every patients and all the patients were divided into four subgroups: LNMR<0.1, 0.1≤LNMR<0.2, 0.2≤LNMR<0.3, LNMR≥0.3. Multivariable Cox regression analysis showed that more RLNC was associated with better CSS and OS in LNMR≥0.3 subgroup (CSS: HR 0.78 (0.63, 0.96) p=0.0213 for cutoff 11 RLNC; OS: HR 0.85 (0.72, 0.99) p=0.0407 for cutoff 11 RLNC, HR 0.9891 (0.9796, 0.9987) p=0.0256 for continuous RLNC). More RLNC is associated with better CSS and OS when the LNMR is over 30%.