bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Motivasi dan Beban Kerja dengan Tingkat Kepatuhan Perawat dalam Melaksanakan Cuci Tangan
Authors: Imron M. Khoirul , Maulidia Ns. Rahmawati , Dafir F Ns. Achmad 
Published: May 2023

Latar Belakang: Tatanan rumah sakit merupakan tempat yang memiliki resiko tinggi terjadinya Healthcare Associated Infection (HAIs). Kepatuhan perawat dalam melaksanakan cuci tangan sangat berpengaruh terhadap timbulnya HAIs. Tujuan: Tujuan dari penelitian ini adalah mengetahui hubungan motivasi dan beban kerja dengan tingkat kepatuhan perawat dalam melaksanakan cuci tangan di Irna 2 RSUD Dr. Saiful Anwar Malang. Metode: Jenis penelitian menggunakan pendekatan cross sectional study, dengan pendekatan korelasi. Populasi pada penelitian ini adalah semua perawat di IRNA 2 RSUD Dr Saiful Anwar Malang, dengan sampel 15 responden. Hasil: Hasil penelitian diperoleh keeratan hubungan antara motivasi dengan tingkat kepatuhan perawat dalam mencuci tangan sebesar 62.3%, hubungan tersebut signifikan (p=0.013). Keeratan hubungan yang antara beban kerja dengan tingkat kepatuhan perawat dalam mencuci tangan sebesar 44.7%, hubungan tersebut tidak signifikan (p=0.095). Kesimpulan: Hampir separuh responden yaitu 7 responden (46,7%) memiliki tingkat motivasi dalam kategori tinggi, lebih dari separuh responden yaitu 8 responden (53,3%) memiliki tingkat beban kerja dalam kategori sedang.
The Effect of Customer Satisfaction on Loyalty of the Lembang Floating Market Tourism Area
Authors: Triandewo Maris Agung , Prasastyo Klemens Wedanaji , Azzahra Alfira 
Published: May 2023

The main purpose of this study is to find out the influence of Customer Experiences on Customer Loyalty through Customer Satisfaction in visitors to the Floating Market Lembang tourist area, Bandung, West Java, assisted by the use of Experience Economy. Experience Economy has four variables, that is, Entertainment, Education, Aesthetic, and Escapist all of which are important to map customers’ tendency to prefer. Research utilizes a type of quantitative research that is descriptive. The data was supported through distribution of questionnaires to respondents with a total of 201. This study utilized statistical methods via SmartPLS 3.0. The results of this study show that except for Education, other variables have positive and significant effect on Customer Satisfaction, that is, Entertainment, Aesthetic, and Escapist. Education does not have impact on Customer Satisfaction because it is likely that customers come to Floating Market Lembang to enjoy and relax, not learn, Thus, they do not need much education aspect of this tourism area. Ultimately, Customer Satisfaction gives impact on Customer Loyalty.
Remote Sensing as a Management and Monitoring Tool for Agriculture: Potential Applications
Authors: Ashraf Atufa , Ahmad Latief , Ferooz Khalid , Ramzan Shazia , Ashraf Ifra , Khan Junaid N. , Shehnaz Efath , Ul-Shafiq Mifta , Akhter Sabia , Nabi Ambreen , Rasool Rehana , Nazir Shaista 
Published: May 2023

Remote sensing technology has revolutionized agriculture management and monitoring by providing valuable information on crop health, soil conditions, weather patterns, and overall land management. The reflectance data are progressively being exploited in agriculture with the momenta gained in ground-based, airborne, and satellite remote sensing. The agriculture systems when managed conventionally don’t facilitate the proper utilization of resources and productivity potential of the soil. However, taking the aid of remote sensing techniques helps in boosting the productivity potential of the soil and optimizing the inputs. This paper aims to review the potential applications of remote sensing in agriculture and its role in improving productivity, resource efficiency, and sustainability. The paper discusses various remote sensing techniques, including satellite imagery, aerial photography, and sensor-based data collection, and their integration with advanced data analysis methods. The applications explored include biomass estimation, yield estimation, global food demand, salinity stress detection, drought monitoring, soil moisture content assessment, and change detection. The paper highlights the benefits and challenges associated with each application and provides insights into future research directions and technology advancements in the field of remote sensing for agriculture.
Burden of Knee Osteoarthritis in 204 Countries and Territories, 1990–2019: Results From the Global Burden of Disease Study 2019
Authors: Yang Guangmin , Wang Jue , Liu Yun , Lu Haojie , He Liu , Ma Changsheng , Zhao Zhe 
Published: May 2023

ObjectiveTo report the global, regional, and national estimates of knee osteoarthritis (OA) burden and associated risk factors (high body mass index [BMI]) by age, sex, and sociodemographic index (SDI) for 204 countries from 1990 to 2019.MethodsWe analyzed the prevalence, incidence, years lived with disability (YLDs), and age‐standardized rates of knee OA using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019. Estimates of the knee OA burden were derived from data modeled using a Bayesian meta‐regression analytical tool (DisMod‐MR 2.1).ResultsThe global prevalence of knee OA in 2019 was ~364.6 million (95% uncertainty interval [95% UI] 315.3 to 417.4). The age‐standardized prevalence in 2019 was 4,376.0 per 100,000 (95% UI 3,793.0 to 5,004.9), an increase of 7.5% between 1990 and 2019. There were ~29.5 million incident cases of knee OA in 2019 (95% UI 25.6 to 33.7), with an age‐standardized incidence of 350.3 per 100,000 (95% UI 303.4 to 398.9). The global age‐standardized YLD resulting from knee OA was 138.2 (95% UI 68.5 to 281.3) per 100,000 population in 2019, an increase of 7.8% (95% UI 7.1 to 8.4) from 1990. Globally in 2019, 22.4% (95% UI 12.1 to 34.2) of YLD resulting from knee OA was attributable to high BMI, an increase of 40.5% since 1990.ConclusionThe prevalence, incidence, YLDs, and age‐standardized rates of knee OA increased substantially in most countries and regions from 1990 to 2019. Continuous monitoring of this burden is important for establishing appropriate public prevention policies and raising public awareness, especially in high‐ and high–middle SDI regions.
Inkjet Printing of All Aqueous Inks to Flexible Microcapacitors for High‐Energy Storage
Authors: Che Junjin , Zakri Cécile , Bronchy Maxime , Neri Wilfrid , Ly Isabelle , Poulin Philippe , Yuan Jinkai 
Published: May 2023

AbstractDue to the low energy density of commercial printable dielectrics, printed capacitors occupy a significant printing area and weight in printed electronics. It has long remained challenging to develop novel dielectric materials with printability and high‐energy storage density. Herein, a novel strategy for inkjet printing of all aqueous colloidal inks to dielectric capacitors composed of carbon nanotube electrodes and polyvinylidene fluoride (PVDF)‐based dielectrics is presented. The formulated dielectric ink is composed of negatively charged PVDF latex nanoparticles complexed with cationic chitosan molecules. Beyond the isoelectric point, the PVDF@Chitosan particles demonstrate excellent printability and film‐forming properties. Chitosan serves as a strong binder to improve the printed film quality yet it introduces charged species. To mitigate the transport of mobile charges, the printed PVDF@Chitosan film is interlayered with a layer of boron nitride nanosheets. This layer is perpendicular to the electric field and serves as an efficient barrier to block the transport and the avalanche of charges, eventually leading to a recoverable energy density of 15 J cm−3at 610 MV m−1. This energy density represents the highest value among the waterborne dielectrics. It is also superior to most of the state‐of‐the‐art dielectric materials printed from solvent‐based formulations.
Molecular Engineering of Noble Metal Aerogels Boosting Electrocatalytic Oxygen Reduction
Authors: Yuan Hongxing , Wan Xinhao , Ye Jianqi , Ma Tuotuo , Ma Fangyuan , Gao Jie , Gao Wei , Wen Dan 
Published: May 2023

AbstractDeveloping robust oxygen reduction reaction (ORR) electrocatalysts with high activity and durability remains great challenging while noble metal aerogels (NMAs) hold great potential because of their hierarchically porous morphology, excellent activity, and self‐supported characteristic. Herein, a general molecular engineering strategy to synthesize molecule‐noble metal aerogels (M‐NMAs) via 3D assembly of metal nanoparticles (e.g., Pt, Pd, Au, Ag, and PtPd NPs) induced by metalloporphyrin as cross‐linkers is reported. Due to the well synergy of NMAs and porphyrin molecule in creating the facile reaction pathway for ORR catalysis, these M‐NMAs demonstrate boosted ORR activity and durability in different electrolytes. Particularly, the best PtPd‐based M‐NMA delivers 1.47 A mgPt−1 and 2.13 mA cm−2 in mass and specific activities, which are 11.3 and 14.2 times higher than those of the commercial Pt/C catalyst, respectively. Thus, this work not only provides a simple and universal functional engineering approach of NMAs with catalytic molecules, but also opens an avenue of the rational design for superior ORR electrocatalysts.
Biodegradable CuMoO4 Nanodots with Multienzyme Activities for Multimodal Treatment of Tumor
Authors: Zhang Jinzha , Peng Liqi , Hao Yijie , Yang Hongna , Zhao Wenbo , Mao Chun 
Published: May 2023

AbstractDue to their complexity and variability, tumors need to be treated with multimodal combined therapy, which requires the development of therapeutic agents that can provide multimodal therapeutic effects. Herein, CuMoO4 nanodots smaller than 10 nm that can be prepared by simple hydrothermal method are reported. These nanodots can be well dispersed in water and have good biosafety and biodegradability. Further studies show that these nanodots also present multienzyme activities, such as catalase, peroxidase and glutathione peroxidase. In addition, CuMoO4 nanodots exhibit high photothermal conversion efficiency (41%) under 1064 nm near‐infrared laser irradiation. In vitro and in vivo experimental results indicate that CuMoO4 nanodots can effectively inhibit the instinctive regulation of tumor cells to oxidative stress, provide sustained treatment to achieve photothermal synergistic ferroptosis, and trigger immune responses to immunogenic cell death. It is worth mentioning that the CuMoO4 nanodots also cause cuproptosis of tumor cells. This study provides a promising nanoplatform for multimodal combined therapy of cancer.
Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta2C Modified with Chondroitin Sulfate (TACS)
Authors: Song Xiangping , Huang Qiong , Yang Yuqi , Ma Liang , Liu Wenguang , Ou Chunlin , Chen Qiaohui , Zhao Tianjiao , Xiao Zuoxiu , Wang Mingyuan , Jiang Yitian , Yang Yunrong , Zhang Jinping , Nan Yayun , Wu Wei , Ai Kelong 
Published: May 2023

AbstractNon‐invasive localization of lesions and specific targeted therapy are still the main challenges for inflammatory bowel disease (IBD). Ta, as a medical metal element, has been widely used in the treatment of different diseases because of its excellent physicochemical properties but is still far from being explored in IBD. Here, Ta2C modified with chondroitin sulfate (CS) (TACS) is evaluated as a highly targeted therapy nanomedicine for IBD. Specifically, TACS is modified with dual targeting CS functions due to IBD lesion‐specific positive charges and high expression of CD44 receptors. Thanks to the acid stability, sensitive CT imaging function, and strong reactive oxygen species (ROS) elimination ability, oral TACS can accurately locate and delineate IBD lesions through non‐invasive CT imaging, and specifically targeted treat IBD effectively because high levels of ROS are a central factor in the progression of IBD. As expected, TACS has much better imaging and therapeutic effects than clinical CT contrast agent and first‐line drug 5‐aminosalicylic acid, respectively. The mechanism of TACS treatment mainly involves protection of mitochondria, elimination of oxidative stress, inhibiting macrophage M1 polarization, protection of intestinal barrier, and restoration of intestinal flora balance. Collectively, this work provides unprecedented opportunities for oral nanomedicines to targeted therapy of IBD.
Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation
Authors: Feng Zhihao , Cheng Yifan , Khlyustova Alexandra , Wani Aasim , Franklin Trevor , Varner Jeffrey D. , Hook Andrew L. , Yang Rong 
Published: May 2023

AbstractAmphiphilic copolymers (AP) represent a class of novel antibiofouling materials whose chemistry and composition can be tuned to optimize their performance. However, the enormous chemistry‐composition design space associated with AP makes their performance optimization laborious; it is not experimentally feasible to assess and validate all possible AP compositions even with the use of rapid screening methodologies. To address this constraint, a robust model development paradigm is reported, yielding a versatile machine learning approach that accurately predicts biofilm formation by Pseudomonas aeruginosa on a library of AP. The model excels in extracting underlying patterns in a “pooled” dataset from various experimental sources, thereby expanding the design space accessible to the model to a much larger selection of AP chemistries and compositions. The model is used to screen virtual libraries of AP for identification of best‐performing candidates for experimental validation. Initiated chemical vapor deposition is used for the precision synthesis of the model‐selected AP chemistries and compositions for validation at solid–liquid interface (often used in conventional antifouling studies) as well as the air–liquid–solid triple interface. Despite the vastly different growth conditions, the model successfully identifies the best‐performing AP for biofilm inhibition at the triple interface.
Blockage of Osteopontin‐Integrin β3 Signaling in Infrapatellar Fat Pad Attenuates Osteoarthritis in Mice
Authors: Dai Bingyang , Zhu Yuwei , Li Xu , Liang Zuru , Xu Shunxiang , Zhang Shian , Zhang Zhe , Bai Shanshan , Tong Wenxue , Cao Mingde , Li Ye , Zhu Xiaobo , Liu Wei , Zhang Yuantao , Chang Liang , Yung Patrick Shu‐hang , Ki‐wai Ho Kevin , Xu Jiankun , Ngai To , Qin Ling 
Published: May 2023

AbstractThe knowledge of osteoarthritis (OA) has nowadays been extended from a focalized cartilage disorder to a multifactorial disease. Although recent investigations have reported that infrapatellar fat pad (IPFP) can trigger inflammation in the knee joint, the mechanisms behind the role of IPFP on knee OA progression remain to be defined. Here, dysregulated osteopontin (OPN) and integrin β3 signaling are found in the OA specimens of both human and mice. It is further demonstrated that IPFP‐derived OPN participates in OA progression, including activated matrix metallopeptidase 9 in chondrocyte hypertrophy and integrin β3 in IPFP fibrosis. Motivated by these findings, an injectable nanogel is fabricated to provide sustained release of siRNA Cd61 (RGD−Nanogel/siRNA Cd61) that targets integrins. The RGD−Nanogel possesses excellent biocompatibility and desired targeting abilities both in vitro and in vivo. Local injection of RGD−Nanogel/siRNA Cd61 robustly alleviates the cartilage degeneration, suppresses the advancement of tidemark, and reduces the subchondral trabecular bone mass in OA mice. Taken together, this study provides an avenue for developing RGD−Nanogel/siRNA Cd61 therapy to mitigate OA progression via blocking OPN‐integrin β3 signaling in IPFP.
Modular Hydrogel Vaccine for Programmable and Coordinate Elicitation of Cancer Immunotherapy
Authors: Ji Panpan , Sun Wenqi , Zhang Siyan , Xing Yuqi , Wang Chen , Wei Mengying , Li Qiuyun , Ji Gang , Yang Guodong 
Published: May 2023

AbstractImmunotherapy holds great promise for the treatment of malignant cancer. However, the lack of sufficient tumor neoantigens and incomplete dendritic cell (DC) maturation compromise the efficacy of immunotherapy. Here, a modular hydrogel‐based vaccine capable of eliciting a powerful and sustained immune response is developed. Briefly, CCL21a and ExoGM‐CSF+Ce6 (tumor cell‐derived exosomes with granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) mRNA encapsulated inside and sonosensitizer chlorin e6 (Ce6) incorporated in the surface) are mixed with nanoclay and gelatin methacryloyl, forming the hydrogel designated as CCL21a/ExoGM‐CSF+Ce6@nanoGel. The engineered hydrogel releases CCL21a and GM‐CSF with a time gap. The earlier released CCL21a diverts the tumor‐draining lymph node (TdLN) metastatic tumor cells to the hydrogel. Consequently, the trapped tumor cells in the hydrogel, in turn, engulf the Ce6‐containing exosomes and thus are eradicated by sonodynamic therapy (SDT), serving as the antigen source. Later, together with the remnant CCL21a, GM‐CSF produced by cells engulfing ExoGM‐CSF+Ce6 continuously recruits and provokes DCs. With the two programmed modules, the engineered modular hydrogel vaccine efficiently inhibits tumor growth and metastasis via diverting TdLN metastatic cancer to hydrogel, killing the trapped tumor cells, and eliciting prolonged and powerful immunotherapy in an orchestrated manner. The strategy would open an avenue for cancer immunotherapy.
Quadrupled Cycle Life of High‐Voltage Nickel‐Rich Cathodes: Understanding the Effective Thiophene‐Boronic Acid‐Based CEI via Operando SHINERS
Authors: Pfeiffer Felix , Diddens Diddo , Weiling Matthias , Frankenstein Lars , Kühn Sebastian , Cekic‐Laskovic Isidora , Baghernejad Masoud 
Published: May 2023

AbstractIncreasing the cell voltage of lithium‐ion batteries (LIBs) is a straightforward approach to increasing their capacity and energy density. However, state‐of‐the‐art cathode materials like LiNixMnyCo1‐x‐yO2 (NMC) suffer from severe failure mechanisms at high operating voltages, significantly degrading the performance and cycle life of the cells. Notably, an effective cathode electrolyte interphase (CEI) mitigates these failure mechanisms. Nevertheless, a deep understanding of the formation mechanisms and properties of the CEI is necessary to tailor effective interphases. This study introduces a promising electrolyte additive for high operating voltage NMC811||graphite cells. Implementing an optimized concentration of 3‐thiophene boronic acid (3‐Thp‐BOH) significantly enhances the cells' performance and reduces capacity fading, resulting in a quadrupled cycle life and a six‐times higher accumulated specific energy. Operando shell‐isolated nanoparticle‐enhanced Raman spectroscopy (SHINERS) is employed to shed light on the formation mechanism and molecular composition of CEI during cell operation, proving that the presence of the additive results in the formation of a complex 3‐Thp‐BOH‐based polymeric CEI on the NMC811 surface. The CEI investigation is additionally supported by scanning electron microscopy and energy dispersive X‐ray analysis and highly accurate quantum chemistry modeling of the suggested polymerization mechanisms.
Eye and airway symptoms in hospital staff exposed to a product containing hydrogen peroxide, peracetic acid, and acetic acid
Authors: Blackley Brie Hawley , Nett Randall J. , Cox‐Ganser Jean M. , Harvey Robert Reid , Virji Mohammed Abbas 
Published: May 2023

AbstractBackgroundSporicidal products containing hydrogen peroxide (HP), peracetic acid (PAA), and acetic acid (AA) are used widely in multiple industries, including healthcare. Despite widespread use in healthcare, few studies have assessed associations between exposures to HP, PAA, and AA, and work‐related symptoms in these settings.MethodsIn 2018, we performed a health and exposure assessment at a hospital where a sporicidal product consisting of HP, PAA, and AA, was used as the primary cleaner on hospital surfaces. We collected 56 personal and mobile air samples for HP, PAA, and AA on participants while they performed their regular cleaning duties; collected area samples for HP (n = 28), PAA (n = 28), and AA (n = 70) in multiple hospital locations where cleaning was performed; and administered a postshift survey to assess eye, skin, and upper and lower airway symptoms that occurred cross‐shift or in the previous 4 weeks.ResultsFull‐shift exposure levels for HP (range: <3–559 ppb), PAA (range: <0.2–8 ppb), and AA (range: <5–915 ppb) were all below US occupational exposure limits. We observed positive associations (p < 0.05) between shift, departmental average, and departmental 95th percentile exposures to HP, PAA, and AA vapors, and work‐related acute (cross‐shift) and chronic (previous 4 weeks) eye, upper airway, and lower airway symptoms after adjusting for age, gender, smoking status, use of other cleaning products containing sensitizers and irritants, allergic status, and stress.ConclusionsOur observations of work‐related upper and lower airway symptoms among hospital workers exposed to vapors from a sporicidal product containing HP, PAA, and AA indicate a need for a combination of engineering, administrative, and PPE controls to reduce exposure. Additionally, alternative nonchemical disinfection technologies should be further investigated as a means to simultaneously reduce healthcare workers' exposure to disinfectants while also minimizing costly healthcare‐acquired infections.
Gold(I)‐Catalyzed Reaction of 1‐(1‐Alkynyl)‐cyclopropyl Ketones with Vinyldiazo Ketones for Divergent Synthesis of Substituted Furanyl Heterocycles
Authors: Narode Akshay Subhash , Liu Rai‐Shung 
Published: May 2023

AbstractGold(I)‐catalyzed reactions between 1‐(1‐alkynyl) cyclopropyl ketones and vinyldiazo ketones to produce substituted [(furan‐3‐yl)ethyl]‐1H‐pyrazol‐5‐yl)methanones are described. In this reaction sequence, we postulate vinyldiazo ketones to undergo a thermal cyclization to produce pyrazole intermediates that attack gold‐containing all‐carbon 1,4‐carbon dipoles to afford the observed products. An atypical N(1)‐regioselectivity is also rationalized in this reaction model.
Synthesis andin vivoEvaluation of Fluorobenzyl Metformin Derivatives as Potential Drugs in The Diabetes Treatment
Authors: Hernández‐Velázquez Edson D. , Herrera Mayra D. , Alba‐Betancourt Clara , Navarro‐Santos Pedro , Ortíz‐Alvarado Rafael , Solorio‐Alvarado César R. 
Published: May 2023

AbstractMetformin is a versatile, biocompatible, and cheap bis‐guanidine used as first response line in the type II diabetes treatment. Since its first human trials (1956) several structural modifications were carried out to increase its activity. However, with this augmented activity, the biological compatibility diminishes, generating serious side effects, such as lactic acidosis. Considering that cytochrome P450 oversees the metformin metabolism and its weakness to eliminate fluorinated metabolites; we envisioned the synthesis of benzyl fluorinated metformin derivatives. In our hypothesis the fluorine atoms can give, by inductive effect, a higher acidity to the hydrogen in the benzylic nitrogen, increasing its solubility. On the other hand, fluorine would give resistance to cP450 allowing the molecule acting longer. Thus, a family of fourteen fluorobenzyl metformins were synthesized and characterized, then anin vitroenzymatic assay with α‐amylase was performed to select the five best performing compounds, then anin vivoexperiment was carried out with streptozotocin‐induced CD1 mice using the selected derivatives. Blood glucose was measured every day. After sacrifice, the lipid profile, serum, and liver γ‐glutamyl transferase (GGT) activity determined the biocompatibility. Results showed two compounds (1 Land1 M) with enhanced activity and higher biocompatibility for blood glucose, lipids metabolism and GGT activity regulation.