bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural and cross-cultural validity of the Afrikaans for the Western Cape Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire
Authors: de Klerk Susan , Jerosch-Herold Christina , Buchanan Helen , van Niekerk Lana 
Published: January 2023

AbstractBackgroundThe Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire has been translated and cross-culturally adapted to Afrikaans for the Western Cape, within the public health service context of South Africa. The aim of this study was to evaluate structural validity, internal consistency, and cross-cultural validity/measurement invariance of this new translation to increase applicability and clinical utility in a public health service context.MethodsDuring this cross-sectional study, exploratory factor analysis (EFA) was conducted with parallel analysis and oblimin rotation. Confirmatory factor analysis (CFA) and multiple group confirmatory factor analysis (MGCFA) to assess cross-cultural validity/measurement invariance, was employed to test model fit withX2goodness-of-fit statistic, root mean square error of approximation (RMSEA), standardized root mean square residual (SRMR) and comparative fit index (CFI). Internal consistency was calculated using Cronbach’s alpha.Results109 women and 110 men (n = 219) completed the Afrikaans for the Western Cape and the South African English DASH questionnaire, used during the analysis. Unidimensionality of the Afrikaans for the Western Cape DASH questionnaire was not supported in the 218 questionnaires eligible for inclusion in the analysis [X2(df) = 1799.10 (405);pvalue = < 0.01; RMSEA (90% CI) = 0.126 (0.120–0.132); SRMR = 0.09 and CFI = 0.984]. EFA revealed a two-factor structure with Eigenvalues exceeding one explaining 55% and 7% of the variance. The two-factor structure of the Afrikaans for the Western Cape DASH questionnaire was supported during CFA. Cronbach’s alpha revealed good internal consistency of both factors [factor 1 = 0.97 (0.96, 0.97) and factor 2 = 0.92 (0.90, 0.94)]. MGCFA conducted between 218 Afrikaans for the Western Cape DASH and 219 South African English DASH questionnaires (N = 437) revealed that the data supports configural, metric and scalar invariance models during initial model fit assessment. Subsequent hypotheses testing comparing the nested models revealed that scalar invariance holds.ConclusionThe Afrikaans for the Western Cape DASH questionnaire revealed a two-factor structure with good internal consistency across the two factors and demonstrated measurement invariance with the South African English DASH questionnaire.
Black aortic valve and coronary arteries in liver transplantation patient: case report
Authors: Vancoillie S. , Roosen J. , Bourgain C. , Depraetere H. 
Published: January 2023

Abstract
Background
Black pigmentation of the aortic valve and coronary arteries has been reported to be caused by alkaptonuria or minocycline. In patients with liver transplantation it has been described only once, after exposure to minocycline. We report a second case of such pigmentation in a liver transplantation patient, for whom none of the known causes are an adequate explanation for this pigmentation.

Case presentation
Our 56-year-old male patient showed a complex history of two liver transplantations and sleeve gastrectomy, and had neither alkaptonuria nor a history of minocycline intake. He underwent an urgent coronary bypass grafting and aortic valve replacement because of an acute coronary syndrome based on three-vessel disease and progressive aortic valve stenosis. During this procedure, the aortic valve and coronary arteries had black pigmentation.

Conclusions
There are causes – other than alkaptonuria and minocycline – that can induce a black pigmentation of the aortic valve and coronary arteries. In patients with a history of liver transplantation, alteration in (dys)functional liver parenchyma or administration of substances related to the procedure of liver transplantation are possible causes. Identifying these is important because they are potentially harmful as they may induce degenerative changes and functional impairment of the aortic valve and coronary arteries. Further research is needed, but proves to be difficult due to the rare nature of this condition.
Proton pump inhibitors as treatment of laryngeal disorders among patients with gastroesophageal reflux disease: a single-arm (pre and post) quasi-experimental study
Authors: Ragaee Mahmoud Ali , Sedik Shaimaa Salah , Ahmed Hanan Abd El Rasheed Mohamed , Mahran Essam Eldeen Mohamed Osman , Roushdy Mohamed Mahmoud 
Published: January 2023

Abstract
Background
Laryngopharyngeal reflux is a silent cause of laryngeal disorders which was documented in the last decade by many studies. This study aimed to evaluate the prevalence of laryngeal reflux in GERD cases and to evaluate the effect of GERD treatment on these laryngeal disorders.

Methodology
In this single-arm (pre and post) quasi-experimental study, eighty patients with GERD were examined for laryngeal disorders by rigid laryngoscopy and assessed by the Reflux Finding Score (RFS). Complaints of patients were evaluated using the 9-item Reflux Symptom Index (RSI) questionnaire. Patients received medical treatment of GERD in the form of proton pump inhibitors (PPIs) only, and they were reassessed after 3 months for improvement in their symptoms and signs using RSI and RFS systems to compare patient complaints and findings in the laryngeal endoscopy pre- and post-treatment.

Results
Among 80 confirmed GERD cases, 70 (87.5%) suffered from laryngeal disorders. Throat clearing and postnasal drip were the most prevalent symptoms, and ventricular obliteration and erythema, vocal fold and diffuse laryngeal edema, and posterior commissure hypertrophy were the most detected signs. Significant improvement in both symptoms and signs after 3 months of PPI therapy was clearly observed. The resistance rate among our studied patients was reported to be 22.4%.

Conclusion
GERD can be considered as an inducer or cause of laryngeal disorders, with a significant direct proportional relationship between the severity of GERD and both the RSI and RFS. PPI greatly improves laryngeal disorders among GERD patients with a high response rate (77.6%).
Cognitive and Behavioral Development of 9-Year-Old Children After Maternal Cancer During Pregnancy: A Prospective Multicenter Cohort Study
Authors: Van Assche Indra A. , Huis in 't Veld Evangeline A. , Van Calsteren Kristel , van Gerwen Mathilde , Blommaert Jeroen , Cardonick Elyce , Halaska Michael J. , Fruscio Robert , Fumagalli Monica , Lemiere Jurgen , van Dijk-Lokkart Elisabeth M. , Fontana Camilla , van Tinteren Harm , De Ridder Jessie , van Grotel Martine , van den Heuvel-Eibrink Marry M. , Lagae Lieven , Amant Frédéric 
Published: January 2023

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. This multicenter cohort study reports on the long-term effects of prenatal exposure to maternal cancer and its treatment on cognitive and behavioral outcomes in 9-year-old children. In total, 151 children (mean age, 9.3 years; range, 7.8-10.6 years) were assessed using a neurocognitive test battery and parent-report behavioral questionnaires. During pregnancy, 109 children (72.2%) were exposed to chemotherapy (only or in combination with other treatment modalities), 18 (11.9%) to surgery only, 16 (10.6%) to radiotherapy, one to trastuzumab, and 16 (10.6%) were not exposed to oncologic treatment. Mean cognitive and behavioral outcomes were within normal ranges. Gestational age at birth showed a positive association with Full Scale Intelligence Quotient (FSIQ), with the average FSIQ score increasing by 1.6 points for each week increase in gestational age (95% CI, 0.7 to 2.5; P < .001). No difference in FSIQ was found between treatment types (F[4,140] = 0.45, P = .776). In children prenatally exposed to chemotherapy, no associations were found between FSIQ and chemotherapeutic agent, exposure level, or timing during pregnancy. These results indicate a reassuring follow-up during the critical maturational period of late childhood, when complex functions develop and rely on the integrity of early brain development. However, associations were observed with preterm birth, maternal death, and maternal education.
Recent Advances in the Role of Autophagy in Endocrine-Dependent Tumors
Authors: Komarla Anvita , Dufresne Suzanne , Towers Christina G 
Published: January 2023

Abstract
Autophagy plays a complex role in several cancer types, including endocrine-dependent cancers, by fueling cellular metabolism and clearing damaged substrates. This conserved recycling process has a dual function across tumor types where it can be tumor suppressive at early stages but tumor promotional in established disease. This review highlights the controversial roles of autophagy in endocrine-dependent tumors regarding cancer initiation, tumorigenesis, metastasis, and treatment response. We summarize clinical trial results thus far and highlight the need for additional mechanistic, preclinical, and clinical studies in endocrine-dependent tumors, particularly in breast cancer and prostate cancer.
Recurrence of Primary Aldosteronism After Surgery in Aldosterone-producing Adenoma With KCNJ5 Gene Mutation
Authors: Aiga Ko , Kometani Mitsuhiro , Aono Daisuke , Yoneda Takashi 
Published: January 2023

Abstract
Primary aldosteronism (PA) is a major cause of secondary hypertension. Aldosterone-producing adenoma (APA) is a subtype of PA, and adrenalectomy is the gold-standard treatment. Recently, a high prevalence of the KCNJ5 gene mutation has been reported in APA, particularly in Japan. Herein, we present 2 extremely rare cases of PA recurrence more than 10 years after adrenalectomy for APA. In the first case, a 52-year-old woman was examined for hypertension 22 years after total adrenalectomy of the right adrenal gland. Recurrent PA was diagnosed based on high aldosterone-renin-ratio (ARR), identification of left adrenal gland tumor by computed tomography (CT), and a confirmatory test. In the second case, a 65-year-old man was examined for hypertension 17 years after total adrenalectomy of the left adrenal gland. He had maintained his blood pressure using medication since the onset of hypertension 4 years after the surgery. A year later, a high ARR was observed. PA recurrence was determined by a right adrenal gland tumor noted on CT and a confirmatory test. Somatic mutations in KCNJ5 were detected in the resected tissues in both cases. We recommend careful follow-ups after adrenalectomy in APA cases, especially in those with a KCNJ5 gene mutation.
Barriers to Screening: An Analysis of Factors Impacting Screening for Type 1 Diabetes Prevention Trials
Authors: Kinney Mara , You Lu , Sims Emily K , Wherrett Diane , Schatz Desmond , Lord Sandra , Krischer Jeffrey , Russell William E , Gottlieb Peter A , Libman Ingrid , Buckner Jane , DiMeglio Linda A , Herold Kevan C , Steck Andrea K 
Published: January 2023

Abstract

Context
Participants with stage 1 or 2 type 1 diabetes (T1D) qualify for prevention trials, but factors involved in screening for such trials are largely unknown.

Objective
To identify factors associated with screening for T1D prevention trials.

Methods
This study included TrialNet Pathway to Prevention participants who were eligible for a prevention trial: oral insulin (TN-07, TN-20), teplizumab (TN-10), abatacept (TN-18), and oral hydroxychloroquine (TN-22). Univariate and multivariate logistic regression models were used to examine participant, site, and study factors at the time of prevention trial accrual.

Results
Screening rates for trials were: 50% for TN-07 (584 screened/1172 eligible), 9% for TN-10 (106/1249), 24% for TN-18 (313/1285), 17% for TN-20 (113/667), and 28% for TN-22 (371/1336). Younger age and male sex were associated with higher screening rates for prevention trials overall and for oral therapies. Participants with an offspring with T1D showed lower rates of screening for all trials and oral drug trials compared with participants with other first-degree relatives as probands. Site factors, including larger monitoring volume and US site vs international site, were associated with higher prevention trial screening rates.

Conclusions
Clear differences exist between participants who screen for prevention trials and those who do not screen and between the research sites involved in prevention trial screening. Participant age, sex, and relationship to proband are significantly associated with prevention trial screening in addition to key site factors. Identifying these factors can facilitate strategic recruitment planning to support rapid and successful enrollment into prevention trials.
Multiple interactions of the dynein-2 complex with the IFT-B complex are required for effective intraflagellar transport
Authors: Hiyamizu Shunya , Qiu Hantian , Vuolo Laura , Stevenson Nicola L. , Shak Caroline , Heesom Kate J. , Hamada Yuki , Tsurumi Yuta , Chiba Shuhei , Katoh Yohei , Stephens David J. , Nakayama Kazuhisa 
Published: January 2023

ABSTRACT
The dynein-2 complex must be transported anterogradely within cilia to then drive retrograde trafficking of the intraflagellar transport (IFT) machinery containing IFT-A and IFT-B complexes. Here, we screened for potential interactions between the dynein-2 and IFT-B complexes and found multiple interactions among the dynein-2 and IFT-B subunits. In particular, WDR60 (also known as DYNC2I1) and the DYNC2H1–DYNC2LI1 dimer from dynein-2, and IFT54 (also known as TRAF3IP1) and IFT57 from IFT-B contribute to the dynein-2–IFT-B interactions. WDR60 interacts with IFT54 via a conserved region N-terminal to its light chain-binding regions. Expression of the WDR60 constructs in WDR60-knockout (KO) cells revealed that N-terminal truncation mutants lacking the IFT54-binding site fail to rescue abnormal phenotypes of WDR60-KO cells, such as aberrant accumulation of the IFT machinery around the ciliary tip and on the distal side of the transition zone. However, a WDR60 construct specifically lacking just the IFT54-binding site substantially restored the ciliary defects. In line with the current docking model of dynein-2 with the anterograde IFT trains, these results indicate that extensive interactions involving multiple subunits from the dynein-2 and IFT-B complexes participate in their connection.
Microtubule–mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast
Authors: Chacko Leeba Ann , Mikus Felix , Ariotti Nicholas , Dey Gautam , Ananthanarayanan Vaishnavi 
Published: January 2023

ABSTRACT
Association with microtubules inhibits the fission of mitochondria in Schizosaccharomyces pombe. Here, we show that this attachment of mitochondria to microtubules is an important cell-intrinsic factor in determining cell division symmetry. By comparing mutant cells that exhibited enhanced attachment and no attachment of mitochondria to microtubules (Dnm1Δ and Mmb1Δ, respectively), we show that microtubules in these mutants displayed aberrant dynamics compared to wild-type cells, which resulted in errors in nuclear positioning. This translated to cell division asymmetry in a significant proportion of both Dnm1Δ and Mmb1Δ cells. Asymmetric division in Dnm1Δ and Mmb1Δ cells resulted in unequal distribution of mitochondria, with the daughter cell that received more mitochondria growing faster than the other daughter cell. Taken together, we show the existence of homeostatic feedback controls between mitochondria and microtubules in fission yeast, which directly influence mitochondrial partitioning and, thereby, cell growth.
This article has an associated First Person interview with the first author of the paper.
Photon-counting detector coronary CT angiography: impact of virtual monoenergetic imaging and iterative reconstruction on image quality
Authors: Sartoretti Thomas , McDermott Michael , Mergen Victor , Euler André , Schmidt Bernhard , Jost Gregor , Wildberger Joachim E , Alkadhi Hatem 
Published: January 2023

Objectives: To assess the impact of low kilo-electronvolt (keV) virtual monoenergetic image (VMI) energies and iterative reconstruction on image quality of clinical photon-counting detector coronary CT angiography (CCTA). Methods: CCTA with PCD-CT (prospective ECG-triggering, 120 kVp, automatic tube current modulation) was performed in a high-end cardiovascular phantom with dynamic flow, pulsatile heart motion, and including different calcified plaques with various stenosis grades and in 10 consecutive patients. VMI at 40,50,60 and 70 keV were reconstructed without (QIR-off) and with all quantum iterative reconstruction (QIR) levels (QIR-1 to 4). In the phantom, noise power spectrum, vessel attenuation, contrast-to-noise-ratio (CNR), and vessel sharpness were measured. Two readers graded stenoses in the phantom and graded overall image quality, subjective noise, vessel sharpness, vascular contrast, and coronary artery plaque delineation on 5-point Likert scales in patients. Results: In the phantom, noise texture was only slightly affected by keV and QIR while noise increased by 69% from 70 keV QIR-4 to 40 keV QIR-off. Reconstructions at 40 keV QIR-4 exhibited the highest CNR (46.1 ± 1.8), vessel sharpness (425 ± 42 ∆HU/mm), and vessel attenuation (1098 ± 14 HU). Stenosis measurements were not affected by keV or QIR level (p > 0.12) with an average error of 3%/6% for reader 1/reader 2, respectively. In patients, across all subjective categories and both readers, 40 keV QIR-3 and QIR-4 images received the best scores (p < 0.001). Conclusion: Forty keV VMI with QIR-4 significantly improved image quality of CCTA with PCD-CT. Advances in knowledge: PCD-CT at 40 keV and QIR-4 improves image quality of CCTA.
Measuring reader fatigue in the interpretation of screening digital breast tomosynthesis (DBT)
Authors: Chen Yan , Sudin Ellhia S , Partridge George JW , Taib Adnan G , Darker Iain T , Phillips Peter , James Jonathan J , Satchithananda Keshthra , Sharma Nisha , Michell Michael J 
Published: January 2023

Objectives: The interpretation of digital breast tomosynthesis (DBT) screening examinations is a complex task for an already overstretched workforce which has the potential to increase pressure on readers leading to fatigue and patient safety issues. Studies in non-medical and medical settings have suggested that changes in blink characteristics can reflect fatigue. The purpose of this study is to investigate the use of blink characteristics as an objective marker of fatigue in readers interpreting DBT breast screening examinations. Methods: Twenty-six DBT readers involved in the UK PROSPECTS trial interpreted a test set of 40 DBT cases while being observed by an eye tracking device from November 2019 to February 2021. Raw data from the eye tracker were collected and automated processing software was used to produce eye blinking characteristics data which were analysed using multiple linear regression statistical models. Results: Of the 26 DBT readers recruited, eye tracking data from 23 participants were analysed due to missing data rendering 3 participants’ data uninterpretable. The mean reading time per DBT case was 2.81 min. There was a statistically significant increase in blinking duration of 0.38 ms/case as the reading session progressed (p < 0.0001). This was the result of a significant decrease in the number of ultra-short blinks lasting ≤50 ms (p = 0.0005) and a significant increase in longer blinks lasting 51–100 ms (p = 0.008). Conclusion Changes in blinking characteristics could serve as objective measures of reader fatigue and may prove useful in the development of DBT reading protocols. Advances in knowledge: Blink characteristics can be used as an objective measure of fatigue; however there is limited evidence of their use in radiological settings. Our study suggests that changes in blink duration and frequency could be used to monitor fatigue in DBT reading sessions.
A Theory-Driven Deep Learning Method for Voice Chat–Based Customer Response Prediction
Authors: Chen Gang , Xiao Shuaiyong , Zhang Chenghong , Zhao Huimin 
Published: January 2023

A Theory-Driven Deep Learning Method for Voice Chat–Based Customer Response Prediction In this study, we target the task of voice chat–based customer response prediction in an emerging online interaction–based commercial mode, the invite-online-and-experience-in-store mode. Prior research shows that satisfaction, which can be revealed by the discrepancy between prior expectation and actual experience, is a key factor to disentangle customers’ purchase intention, whereas black box deep learning methods empirically promise us with advantageous capabilities in dealing with complex voice data, for example, text and audio information incorporated in voice chat. To this end, we propose a theory-driven deep learning method that enables us to (1) learn customers’ personalized product preferences and dynamic satisfaction in the absence of their profile information, (2) model customers’ actual experiences based on multiview voice chat information in an interlaced way, and (3) enhance the customer response prediction performance of a black box deep learning model with theory-driven dynamic satisfaction. Empirical evaluation results demonstrate the advantageous prediction performance of our proposed method over state-of-the-art deep learning alternatives. Investigation of cumulative satisfaction reveals the collaborative predictive roles of theory-driven dynamic satisfaction and deep representation features for customer response prediction. Explanatory analysis further renders insights into customers’ personalized preferences and dynamic satisfaction for key product attributes.
Two-Stage Stochastic Matching and Pricing with Applications to Ride Hailing
Authors: Feng Yiding , Niazadeh Rad , Saberi Amin 
Published: January 2023

Two-Stage Matching and Pricing in Ride-Hailing Platforms Matching and pricing are two critical levers in two-sided marketplaces to connect demand and supply. The platform can produce more efficient matching and pricing decisions by batching the demand requests. We initiate the study of the two-stage stochastic matching problem with or without pricing to enable the platform to make improved decisions in a batch with an eye toward the imminent future demand requests. This problem is motivated in part by applications in online marketplaces, such as ride-hailing platforms. We design online competitive algorithms for vertex-weighted (or unweighted) two-stage stochastic matching for maximizing supply efficiency and two-stage joint matching and pricing for maximizing market efficiency. Using various techniques, such as introducing convex programming–based matching and graph decompositions, submodular maximization, and factor-revealing linear programs, we obtain either optimal competitive or improved approximation algorithms compared with naïve solutions. We enrich our theoretical study by data-driven numerical simulations using DiDi’s ride-sharing data sets.