bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrocardiographic Pattern of Pregnant Women with Advanced Maternal Age
Authors: Mangkoesoebroto Arjatya Pramadita , Pramono Besari Adi , Mochtar Aruman Yudanto Ariwibowo Binarso 
Published: July 2023

Background: Advanced maternal age (AMA) is becoming increasingly common and is associated with increased maternal and fetal morbidity and mortality. Around 22,2% of maternal deaths were found to be from cardiovascular disease, and women with higher cardiovascular mortality were likely older. Electrocardiography (ECG) is a simple tool for detecting cardiovascular problems. Though there are many studies of the ECG in normal pregnant women, there is still limited data on the ECG pattern in pregnant women with AMA.Objective: Describe the characteristics of the ECG pattern in woman with AMA.Methods: This study used data retrospectively from medical records of patient in Kariadi General Hospital Semarang from 1st to 30th October 2018. The inclusion criteria were advanced age ³ 35 years, in the last trimester. Demography, clinical, laboratory , and 12-lead ECG data were collected and reported.Results: Thirteen patients were obtained, with mean age of 38,3 years. Majority of patients had preeclampsia (61,5%) and superimposed preeclampsia (15,4%). Mean systolic blood pressure was 168 mmHg. All of the patients was sinus rhythm, with a mean heart rate 92,5 bpm. Mean QTc was 430,7ms, with 3 patients (23,1%) having borderline prolongation grade. Another abnormality was a left atrial abnormality in 3 patients (23,1%), poor R wave progression in 2 patients (15,4%), and a pathological Q wave in 1 patients (7,7%).Conclusion: ECG abnormalities are seen in 38,4% of pregnant women over 35 years old. The performance of an ECG in AMA may be a first step toward improved pregnancy outcomes since it is widely available and easily interpreted by general practitioners.
The Effect of Early Mobilization on Functional Status of Stroke Patients: A Literature Review
Authors: Mustikaningrum Retno Endarwati , Handayani Fitria , Hastuti Yuni Dwi , Latumanuwij Romy , Fieten Marloes 
Published: July 2023

Stroke impact to the altering functional status. Early mobilization is one of stroke care components that can minimize impact due to altering functional status such as weakness and paralysis in stroke patients. The review of early mobilization was proved increasing the functional status among critical illness patients. Limited review regarding the effect of early mobilization on changes in the level of functional status of stroke patients The aim the study was to determine the effect of early mobilization at the level of functional status of stroke patients. This research used the literature review with the MeSH search tool. The keywords and syntax included "stroke", "early mobilization", and "functional status". Articles found with keywords early mobilization; functional status; stroke retrieve 12,114 articles, namely 2069 articles from Proquest, 4774 articles from Pubmed, 35 articles from Scopus, and 5236 articles from ScienceDirect which were filtered based on the specified criteria and obtained 10 articles for review published in the period 2011-2021, with patient research samples strokes. The effect of early mobilization mostly showedan increasing degree of functional status level among stroke patients. It is recommended to provide early mobilization among stroke patient. Future research should conduct a meta-analysis in analysing effect of early mobilisation among stroke patients.
Efektivitas Pendidikan Politik Tingkat SMA/Sederajat dengan Aplikasi E-Pemilos di Kabupaten Kulon Progo, Daerah Istimewa Yogyakarta
Authors: Al-Hamdi Ridho , Khairiyah Miftahul , Khairiyah Miftahul 
Published: July 2023

Pemilihan Ketua Organisasi Siswa Intra Sekolah (Pemilos) dengan aplikasi e-pemilos yang diselenggarakan oleh KPU Kabupaten Kulon Progo bekerjasama dengan Dinas Komunikasi dan Informasi (Diskominfo) Kabupaten Kulon Progo merupakan sebuah inovasi untuk melaksanakan Pemilos walaupun di era pandemi Covid-19. Hal tersebut menarik untuk ditelaah lebih lanjut mengingat kegiatan Pemilos berbasis aplikasi elektronik dilaksanakan secara serantak di Kabupaten Kulon Progo tahun 2021. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas pendidikan politik tingkat SMA/sederajat di Kabupaten Kulon Progo dengan aplikasi e-pemilos. Secara metodologis, artikel ini merupakan hasil penelitian kualitatif dengan pendekatan studi kasus. Untuk pengumpulan data, studi ini menggunakan diskusi kelompok terumpun (focus group discussion, FGD), wawancara, dan studi dokumentasi. Temuan studi ini menunjukkan, bahwa pada indikator pencapain tujuan, program Pemilos telah dilaksanakan sesuai batasan waktu yang telah direncanakan, partisipasi siswa sekolah yang mengikuti program ini cukup tinggi, dan asas Pemilu (langsung, umum, bebas, rahasia, jujur dan adil) dapat diterapkan. Pada indikator integrasi, sosialisasi Pemilos kurang efektif karena sosialisasi tidak berdampak pada baiknya pemahaman siswa tentang teknis pelaksanaan Pemilos serta siswa tidak memahami manfaat dari program tersebut. Sementara pada indikator adaptasi, pelaksanaan secara daring (online) semakin tidak meyakinkan siswa tentang pentingnya Pemilos ini. Selain itu, sarana-prasarana juga termasuk kurang efektif karena tidak semua pemilih mempunyai fasilitas yang sama. Dari tiga indikator, pelaksanaan Pemilos hanya efektif pada pencapaian tujuan saja. Karena itu, Pemilos dengan aplikasi e-pemilos masih belum efektif dan perlu dilakukan evaluasi secara menyeluruh.
Phytochemical analysis and anticancer activity of the Pithecellobium dulce seed extract in colorectal cancer cells
Authors: Alhamed Abdullah S. , Alqinyah Mohammed , Alghaith Adel F. , Algahtani Mohammad M. , Alqahtani Faleh , Nasr Fahd A. , Alqahtani Ali S. , Noman Omar M. , Bazaid Abdulrahman S. , AlMalki Reem Hussain , Abdel Rahman Anas M. , Alhazzani Khalid , Alanazi Ahmed Z. 
Published: July 2023

Abstract
Colorectal cancer remains a challenging medical issue worldwide, and utilizing natural products and plants to produce novel, effective and safe therapies against this disease is continuously a sought-after strategy. Fruit and leaf extracts of Pithecellobium dulce (P. dulce) showed potential anticancer properties as they induced apoptosis of breast cancer and Dalton’s lymphoma ascites cells. Thus, the main objective of the current study is to determine whether the seed extract of P. dulce will affect apoptosis, cell cycle, migration, and inflammation of LoVo colorectal cancer cells. The high-resolution liquid chromatography–mass spectrometry was used to determine the chemical composition of the P. dulce seed extract, which revealed the presence of 35 phytochemicals. The findings of this study indicated a significant cytotoxic effect of seeds of this plant in colorectal cancer characterized by induction of apoptosis, cell cycle arrest, and reduction of migration. In addition, the seed extract suppressed several genes that are essential for cancer progression such as MMP2, MMP9, and IL-8, and, on the other hand, upregulated pro-apoptotic genes such as BAX and P53. This study has established P. dulce as a potential and valuable source for providing future therapies against colorectal cancer and other cancers.
Performance analysis on the structure of the bracket mounting for hybrid converter kit: Finite-element approach
Authors: Effendi Ma’ruf Yanuar , Ubaidillah Ubaidillah , Budiana Eko Prasetya , Lenggana Bhre Wangsa 
Published: July 2023

Abstract
An electric motor mounting bracket is used in electric vehicles, especially hybrid ones using a parallel hybrid configuration. This study aims to analyze the strength and performance of the initial design and topology optimized design. This study uses the finite-element method (FEM) in the bracket design modeling by applying topology optimization. The topology optimization results show a mass reduction of 50% from the initial design mass. In the case of static loading, the results of optimized design 2 have a stress of 142.19 MPa and a safety factor of 3.09. While optimized design 1 has a stress of 313.8 MPa and a safety factor of 1.4. In terms of dynamic loading, the initial design, optimized design 1, and optimized design 2 have the first natural frequency, which is higher than the operating frequency of the electric motor, respectively, 100.49, 69.043, and 74.864 Hz. Optimized design 1 has the lowest natural frequency and the highest amplitude compared to the initial design, and optimized design 2 has lower damping characteristics. The study results conclude that optimized design 2 is superior in static and dynamic loading.
“That’s all it takes to be trans”: counter-strategies to hetero- and transnormative discourse on YouTube
Authors: Bruns Hanna 
Published: July 2023

Abstract
The discourse surrounding transgender people has for a long time been influenced by certain narrative practices necessary to authenticate people’s trans status to medical professionals. This conventional narrative (master narrative), based on ideals of hetero- and cisnormativity, has led to stereotypical representations of trans identities. These largely continue to exist today. Nevertheless, counter-discourse to these stereotypical representations is becoming more prominent. Particularly YouTube has become an increasingly popular platform for counter-discursive action. The current case study therefore focusses on two transgender YouTubers who challenge the normative ideals by creating their own counter-discourse. The YouTubers address four major topics of stereotypical representation: the ideal of binary gender, heterosexuality, the wish to transition in order to pass as cisgender, and the belief that transgender people have always identified as the other gender. The two creators recognise the discursively reproduced stereotypes and use a combination of five different strategies to refute them: Inversion, Parody, Complexification, Shift, and Personal Experience. Making use of these strategies, the subjects’ positive discourse aims at presenting a multi-faceted representation of transgender identities.
A case of concomitant leukemoid reaction and mucormycosis in a patient with severe COVID-19 infection
Authors: Sayed Issa Rand , Mushtaq Gohar , Unnisa Aziz , Mahli Abdo 
Published: July 2023

Abstract

Objectives
Leukemoid Reaction (LR) signifies leukocytosis characterized by mature neutrophils. The incidence of LR is about 1 % among hospitalized patients. Mucormycosis is a rare, aggressive, fatal fungal infection that afflicts immune-compromised patients. This study discusses the case of concomitant leukemoid reaction and mucormycosis in a patient with severe COVID-19 infection.

Case presentation
A 45-year-old female patient was presented to the hospital with confirmed SARS-CoV-2 and was given supplemental oxygen and placed on mechanical ventilation. Her skin biopsy revealed non-septate hyphae with wide-angle branching. Her blood tests also revealed the presence of LR.

Conclusions
Severe COVID-19 infection causes new-onset hyperglycemia, which can lead to metabolic acidosis, toxic metabolite accumulation in the body due to renal failure, the release of stress hormones and inflammatory cytokines, and the occurrence of secondary bacterial and opportunistic fungal infections. The study has shown that LR in severe COVID-19 may be associated with severe infections (bacterial or fungal) and other pathophysiological changes in the body.
EHMT2 affects microglia polarization and aggravates neuronal damage and inflammatory response via regulating HMOX1
Authors: Yang Huaitao , Chen Zhifang , Gao Wenhong 
Published: July 2023

Abstract

Objective
This research was designed to ascertain the function of euchromatic histone lysine methyltransferase 2 (EHMT2) in ischemic stroke-induced neuronal damage and inflammatory response and its regulatory mechanism.

Methods
Mouse microglia (BV-2 cells) were induced by oxygen glucose deprivation/reoxygenation (OGD/R) to establish a cellular model, and then co-cultured with HT22 hippocampal neurons. After that, HT22 cell viability and apoptosis were evaluated, followed by the measurement of apoptosis-related factors (B-cell lymphoma-2, Bcl-2 associated X, and cleaved-Caspase 3). Meanwhile, the expression of inducible nitric oxide synthase (M1 microglia polarization marker) and arginase 1 (M2 microglia polarization marker) in BV-2 cells was detected, as well as the levels of inflammatory factors (tumor necrosis factor-α, interleukin [IL]-6, IL-10, IL-1β, and IL-4). Additionally, the expression of EHMT2 and heme oxygenase 1 (HMOX1) in BV-2 cells was assessed by quantitative reverse transcription polymerase chain reaction and western blot, and the binding between EHMT2 and HMOX1 was predicted and verified.

Results
OGD/R treatment led to decreased cell viability and increased cell apoptosis in HT22 cells, and aggravated inflammatory response in BV-2 cells. In OGD/R-induced BV-2 cells, EHMT2 and HMOX1 were increasingly expressed, and knockdown of EHMT2 or HMOX1 in BV-2 cells could inhibit neuronal damage and inflammatory response. Moreover, EHMT2 promoted HMOX1 transcription level by histone methylation.

Conclusion
Collected evidence showed that down-regulation of EHMT2 relieved neuronal damage and inflammatory response by inhibiting HMOX1 expression.
The Genetic Basis of Decathlon Performance: An Exploratory Study
Authors: Remmel Liina , Ben-Zaken Sigal , Meckel Yoav , Nemet Dan , Eliakim Alon , Jürimäe Jaak 
Published: July 2023

Abstract
Remmel, L, Ben-Zaken, S, Meckel, Y, Nemet, D, Eliakim, A, and Jürimäe, J. The genetic basis of decathlon performance: an exploratory study. J Strength Cond Res 37(8): 1660–1666, 2023—Decathlon is a combined track and field competition consisting of 10 different events, most of which are anaerobic-type events. Therefore, it is assumed that an anaerobic genetic predisposition might be prevalent among decathletes. Yet, to the best of our knowledge, the genetic basis of decathlon performance had not been studied. Therefore, the aim of this study was to assess the prevalence genetic polymorphisms associated with power performance (AGT, rs699, Met235Thr T/C), speed (ACTN3, rs1815739 C1747T), aerobic endurance (PPARD, rs2016520 T294C), and lactate clearance (MCT1, rs1049434 A1470T) among decathletes. One hundred thirty-seven male track and field athletes (51 sprinters and jumpers, 59 long distance runners, and 27 decathletes) participated in the study. Genomic DNA was extracted from buccal epithelial cells. Genotypes were determined using the Taqman allelic discrimination assay. Decathletes had a higher prevalence of the ACTN3 RR genotype, which is associated with speed ability, and a lower prevalence of the PPARD CC genotype, which is associated with endurance performance compared with long-distance runners. Decathletes had a higher prevalence of the AGT CC genotype associated with strength performance and a higher prevalence of the MCT1 TT genotype, which is associated with improved lactate transport compared with both sprinters and jumpers and long-distance runners. The results suggest that a favorable genetic polymorphism for strength-related capability might be advantageous for decathletes, whereas a genetic makeup favoring aerobic performance is not necessary.
The Effects of Strength and Conditioning Interventions on Sprinting Performance in Team Sport Athletes: A Systematic Review and Meta-Analysis
Authors: Murphy Andrew , Burgess Katherine , Hall Andy J. , Aspe Rodrigo R. , Swinton Paul A. 
Published: July 2023

Abstract
Murphy, A, Burgess, K, Hall, AJ, Aspe, RR, and Swinton, PA. The effects of strength and conditioning interventions on sprinting performance in team sport athletes: a systematic review and meta-analysis. J Strength Cond Res 37(8): 1692–1702, 2023—Linear sprinting is a key determinant of athletic performance within team sports. The aims of the review were to quantify and compare the effectiveness of popular strength and conditioning (S&C) training modes to improve sprint performance in team sport athletes, with additional focus on potential moderators and the relationships between improvements in physical factors (e.g., strength, power, and jump performance) and improvements in sprint performance. Inclusion was restricted to resistance, plyometric, sprint, and combined training interventions comprising team sport athletes. Multilevel, Bayesian’s meta-analysis and meta-regression models conducted with standardized mean difference effect sizes were used to investigate training modes and potential moderators. Weighted regression models conducted on shrunken estimates from initial Bayesian’s meta-analyses were used to quantify relationships between improvements in physical factors and sprint performance. Certainty of evidence was assessed using the grading of recommendations assessment development and evaluation (GRADE) approach. Similar improvements in sprint performance were obtained across training modes, with some evidence of the largest effects with resistance training (

= 0.55 [95% credible interval [CrI]: 0.36–0.78; very low certainty]). A strong moderating effect of training intensity was identified across all training modes with evidence of greater improvements in sprint performance with high-intensity training (

= 0.17 [95% CrI: 0.01–0.33; very low certainty]). Strong positive relationships were identified between improvements in all physical factors and sprint performance (

= 0.56 [95% CrI: 0.36–0.77; low certainty],

= 0.80 [95% CrI: 0.50–1.0; low certainty],

= 0.78 [95% CrI: 0.57–0.97; low certainty]). The findings indicate that focus on developing speed in team sport athletes should be placed on S&C training with high intensities, including the use of resisted sprint training.
Excitation and Inhibition Delays within a Feedforward Inhibitory Pathway Modulate Cerebellar Purkinje Cell Output in Mice
Authors: Binda Francesca , Spaeth Ludovic , Kumar Arvind , Isope Philippe 
Published: July 2023

The cerebellar cortex computes sensorimotor information from many brain areas through a feedforward inhibitory (FFI) microcircuit between the input stage, the granule cell (GC) layer, and the output stage, the Purkinje cells (PCs). Although in other brain areas FFI underlies a precise excitation versus inhibition temporal correlation, recent findings in the cerebellum highlighted more complex behaviors at GC–molecular layer interneuron (MLI)–PC pathway. To dissect the temporal organization of this cerebellar FFI pathway, we combinedex vivo patch-clamp recordings of PCs in male mice with a viral-based strategy to express Channelrhodopsin2 in a subset of mossy fibers (MFs), the major excitatory inputs to GCs. We show that although light-mediated MF activation elicited pairs of excitatory and inhibitory postsynaptic currents in PCs, excitation (E) from GCs and inhibition (I) from MLIs reached PCs with a wide range of different temporal delays. However, when GCs were directly stimulated, a low variability in E/I delays was observed. Our results demonstrate that in many recordings MF stimulation recruited different groups of GCs that trigger E and/or I, and expanded PC temporal synaptic integration. Finally, using a computational model of the FFI pathway, we showed that this temporal expansion could strongly influence how PCs integrate GC inputs. Our findings show that specific E/I delays may help PCs encoding specific MF inputs.SIGNIFICANCE STATEMENTSensorimotor information is conveyed to the cerebellar cortex by mossy fibers. Mossy fiber inputs activate granule cells that excite molecular interneurons and Purkinje cells, the sole output of the cerebellar cortex, leading to a sequence of synaptic excitation and inhibition in Purkinje cells, thus defining a feedforward inhibitory pathway. Using electrophysiological recordings, optogenetic stimulation, and mathematical modeling, we demonstrated that different groups of granule cells can elicit synaptic excitation and inhibition with various latencies onto Purkinje cells. This temporal variability controls how granule cells influence Purkinje cell discharge and may support temporal coding in the cerebellar cortex.
microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes
Authors: Sako Hiroaki , Youssef Mohieldin , Elisseeva Olga , Akimoto Takayuki , Suzuki Katsuhiko , Ushida Takashi , Yamamoto Tadashi 
Published: July 2023

AbstractSlower translation rates reduce protein misfolding. Such reductions in speed can be mediated by the presence of non‐optimal codons, which allow time for proper folding to occur. Although this phenomenon is conserved from bacteria to humans, it is not known whether there are additional eukaryote‐specific mechanisms which act in the same way. MicroRNAs (miRNAs), not present in prokaryotes, target both coding sequences (CDS) and 3′ untranslated regions (UTR). Given their low suppressive efficiency, it has been unclear why miRNAs are equally likely to bind to a CDS. Here, we show that miRNAs transiently stall translating ribosomes, preventing protein misfolding with little negative effect on protein abundance. We first analyzed ribosome profiles and miRNA binding sites to examine whether miRNAs stall ribosomes. Furthermore, either global or specific miRNA deficiency accelerated ribosomes and induced aggregation of a misfolding‐prone polypeptide reporter. These defects were rescued by slowing ribosomes using non‐cleaving shRNAs as miRNA mimics. We finally show that proinsulin misfolding, associated with type II diabetes, was resolved by non‐cleaving shRNAs. Our findings provide a eukaryote‐specific mechanism of co‐translational protein folding and a previously unknown mechanism of action to target protein misfolding diseases.
“Navigating The Storm”: Peran Grit sebagai Penghambat Stres Mahasiswa di Masa Pandemi
Authors: Amawidyati Sukma Adi Galuh , Rizki Binta Mu’tiya , Ulya Laila Listiyana 
Published: July 2023

Pandemi COVID-19 memunculkan tantangan global terhadap kesejahteraan, baik secara fisik maupun psikologis. Berbagai hasil penelitian menunjukkan bahwa dampak negatif yang muncul selama pandemi adalah permasalahan terkait kesehatan mental, salah satunya adalah stres. Salah satu faktor protektif yang dapat mempengaruhi stres seseorang adalah grit. Grit memiliki pengaruh kuat untuk menurunkan stres karena merupakan salah satu sumber psikologis yang dapat meningkatkan resiliensi dalam diri. Penelitian ini bertujuan untuk melihat peran grit terhadap stress pada mahasiswa di masa pandemi. Teknik sampling yang digunakan dalam penelitian ini adalah convenience sampling. Responden yang terlibat dalam penelitian ini berjumlah 258 mahasiswa. Instrumen yang digunakan dalam penelitian ini adalah Skala Grit dan sub skala stres pada skala Depression Anxiety Stress Scale (DASS-42). Analisis data dalam penelitian ini dilakukan dengan analisis regresi sederhana menggunakan software statistik open source Jamovi. Hasil penelitian menunjukkan bahwa grit memiliki peran negatif terhadap stres (F=8,14; p0,05). Grit memberikan sumbangan efektif 6,7% terhadap stres. The COVID-19 pandemic creates global challenges to well-being, both physically and psychologically. Various research results show that the negative impacts that emerged during the pandemic were problems related to mental health, one of which was stress. One of the protective factors that can affect a person's stress is grit. Grit has a strong influence on reducing stress because it is a psychological source that can increase self-resilience. This study aims to see the role of grit in stress on students during a pandemic. We use convenience sampling in this research. Respondents involved in this study amounted to 258 students. The instruments used in this study were the grit scale and the stress sub-scale on the Depression Anxiety Stress Scale (DASS-42). Data analysis in this study was carried out by simple regression analysis using the open-source statistical software Jamovi. The results showed that grit negatively affected stress (F=8.14; p0.05). Grit's contribution to stress is 6.7%.