bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of spine adipose index in predicting the risk for septic spondylodiscitis after lumbar percutaneous laser disc decompression
Authors: Stepanov I. A. , Beloborodov V. A. 
Published: March 2023

The aim. To analyze the role of the spine adipose index (SAI) in predicting the risk of septic spondylodiscitis after lumbar percutaneous laser disk decompression (PLDD).Material and methods. A retrospective observational single-center study was performed. Various clinical and instrumental parameters have been studied, including the spine adipose index, which are potential risk factors for the development of postprocedural septic spondylodiscitis.Results. The study included 219 patients who underwent PLDD for degenerative lumbar disk disease. The average period of postoperative observation was 30.8 ± 13.3 months. Signs of septic spondylodiscitis were detected in 5 (2.28%) cases. Multivariate analysis showed that III degree of anesthesiological risk by the American Society of Anesthesiologists (ASA) scale (p = 0.021), a high value of body mass index (more than 25 kg/m2) (p = 0.043) and a high value of SAI (over 0.7) (p = 0.037) are statistically significantly associated with the development of septic spondylodiscitis in patients who underwent lumbar PLDD.Conclusion. The value of SAI is statistically significantly associated with the development of spondylodiscitis in patients who underwent PLDD for degenerative lumbar disk disease.
Results of surgical treatment of ptosis of the upper eyelid by the dosed muscle-conjunctival resection of the upper cartilage
Authors: Bikbov M. M. , Ishbulatov R. Sh. , Lukyanova E. E. 
Published: March 2023

Blepharoptosis is an abnormally low position of the upper eyelid in relation to the eyeball due to its omission. The method of surgical treatment of blepharoptosis depends on the function of the levator.The aim. To analyze the results of surgical treatment of partial blepharoptosis of various etiology by the dosed muscle-conjunctival resection of the upper eyelid cartilage.Material and methods. We operated 78 patients (82 eyes) with blepharoptosis, among them with congenital blepharoptosis – 34 people (36 eyes), with acquired – 44 (46 eyes). The patients’ age was from 6 to 82 years.Inclusion criteria: the function of the upper eyelid levator – more than 5 mm, the width of the palpebral fissure – 3 mm or more.The patients underwent a dosed muscle-conjunctival resection of the upper eyelid cartilage in the period from 2018 to 2021. The follow-up period ranged from 2 months to 2 years.Results. Elimination of blepharoptosis was achieved in all patients. With congenital blepharoptosis, a good result was obtained in 33 people (91.7 %), satisfactory – in three patients (8.3 %), which was associated with the asymmetry of the palpebral fissure, for the correction of which these patients underwent additional intervention. In patients with acquired ptosis of the upper eyelid, a good result was achieved in 91.3 % of cases (42 eyes). One patient underwent repeated surgery due to hypocorrection and asymmetry of the palpebral fissure width after the first surgery.In all patients, the result remained stable throughout the observation period.Conclusion. The use of the method of dosed muscle-conjunctival resection of the upper eyelid cartilage in patients with partial ptosis of the upper eyelid and intact levator function made it possible to obtain a good cosmetic and functional result: with congenital blepharoptosis – in 91.7 % of cases, acquired ptosis of the upper eyelid – in 91.3 % patients.
Videolaparoscopic surgical treatment of strangulated paraesophageal hiatal hernia (clinical observation)
Authors: Gankov V. A. , Shestakov D. Yu. , Andreasyan A. R. , Tseymakh E. A. 
Published: March 2023

Relevance. Paraesophageal hiatal hernias are much less common than other types of diaphragmatic hernias. The risk of strangulation in this pathology is about 21 %. It is often very difficult to establish the correct diagnosis in time, because patients are admitted with an atypical clinic of acute cardiological or pulmonary pathology. Usually, the correct diagnosis is established only on the 4th day. Due to late diagnosis, necrosis and perforation of the strangulated organ occur, which causes high mortality; sometimes the correct diagnosis is established only at autopsy.Clinical observation. The patient was admitted to the surgical department on an emergency basis with complaints of intense pain in the lower chest and epigastric region, vomiting of eaten food. From the anamnesis it is known that about a year ago, periodic nausea and vomiting of food eaten began to bother. The last 12 hours before admission to the hospital, pain in the chest and epigastrium intensified, all eaten food came out with vomiting. X-ray diagnosed strangulated paraesophageal hernia of the esophageal opening of the diaphragm. During esophagogastroduodenoscopy it was impossible to pass into the distal parts of the stomach; hyperemia and petechial hemorrhages were detected in the zone of strangulation. Video-laparoscopic reduction of the hernial contents, resection of the hernial sac and anterior diaphragm crurorrhaphy were urgently performed. The early postoperative period was uneventful. The presented clinical observation indicates the promise of using video-endoscopic technologies for diagnosis and treatment of strangulated diaphragmatic hernias. The key to success is the timely establishment of the correct diagnosis. We consider it impractical to perform an antireflux intervention simultaneously in conditions of an acute inflammatory process.
Eating disorders in 11–17 year old schoolgirls: Prevalence, features of clinical manifestations, psychosomatic comorbidity
Authors: Semenova N. B. , Slobodskaya H. R. , Reuzn E. V. 
Published: March 2023

Background. Eating disorders are an urgent public health problem due to their high prevalence and mortality. The disease prognosis depends on timely diagnosis; however, these conditions are sure to be underestimated.The aim. To study the prevalence, features of clinical manifestations and psychosomatic comorbidity of eating disorder (ED) and subthreshold eating disorder (SED) in schoolgirls aged 11–17 years.Materials and methods. We examined 917 schoolgirls aged 11–17 years. The screening questionnaire including 11questions combined into three pools named “Thoughts about one’s own body” was used. The first pool (A) – assessed body dissatisfaction, the second one (B) – eating disorders, the third one (C) – food intake disorders. The answers were encoded as “1”, “2”, “3” (“false”, “rather true”, “true”). Schoolgirls who scored the maximum number of points (12) in the pool A were regarded as dissatisfied with their body and were further divided into two groups: the first group (ED) included girls who scored more than 10 points in the pool B; girls who scored less than 10 points were in the second group (SED), respectively. Body mass index (BMI) was determined by the weight-height coefficient correlated with centile tables. Psychosomatic comorbidity was assessed by the presence of recurrent headache and abdominal pain in the last six months.Results. The overall prevalence of eating disorders was 11.7 %, where ED made 2.1 %, SED – 9.6 %. All schoolgirls had abnormal eating behavior; however, those with SED used less aggressive weight-loss methods. BMI ˂ 5th percentile was observed in 10 % of girls with ED and 4.5 % – with SED. 60 % of girls with ED and 40.9 % with SED complained about frequent headaches; 30 % of girls with ED and 20.4 % with SED were suffering from frequent abdominal pain.Conclusion. In schoolgirls, subthreshold eating disorder is 4.6 times more common than threshold eating disorder. Characteristics of clinical manifestations are the absence of underweight for most schoolgirls and comorbidity with pain syndrome.
The effect of a high-calorie diet on the total content of chemical elements and metal-ligand forms of zinc in the blood serum and liver of Wistar rats
Authors: Notova S. V. , Marshinskaia O. V. , Kazakova T. V. , Sheida E. V. 
Published: March 2023

Background. Worldwide, there is a rapid increase in the number of people suffering from various forms of carbohydrate and lipid metabolism disorders. Modern studies show that the transport, distribution, excretion and accumulation of chemical elements in these types of metabolic disorders change in different ways and affect the further functional state of the body differently.The aim. To evaluate the level of macro- and microelements in the blood serum and liver, as well as the content of metal-ligand forms of zinc in the blood serum of a Wistar rat in a high-calorie diet.Materials and methods. Thirty male rats were selected for the experiment, from which two groups were formed: control (n = 15) and experimental (n = 15). The animals of the control group received the basic diet (270 kcal/100 g), and the animals of the experimental group received a high-calorie diet. During the experiment, the caloric content of the diet of the experimental group gradually increased from the caloric content of the total diet. During the study, body weight, biochemical parameters of blood and urine were evaluated. The analysis of macro- and microelements in the samples was carried out using inductively coupled plasma mass spectrometry. Determination of the content of individual zinc compounds in blood serum was carried out using a combination of a chromatograph and a mass spectrometer.Results. It was found that a high-calorie diet led to a decrease in the level of iron, chromium, iodine, zinc, potassium, calcium, and an increase in vanadium in blood serum. In the liver, there was a decrease in the level of lithium and an increase in the level of calcium, vanadium, chromium, iron, zinc, cobalt. When assessing the chemical forms of zinc in the blood serum, a percentage increase in the albumin fraction was recorded against the background of a decrease in amino acid complexes and low-molecular-weight forms of zinc.Conclusion. The data obtained suggest that a high-calorie diet leads to an imbalance of chemical elements, which can serve as one of the triggers for dysregulation of a number of physiological functions of the body.
Using dot-immunoassay in decoding the outbreak of pseudotuberculosis in the Tomsk region
Authors: Zagoskina T. Yu. , Markov E. Yu. , Andreevskaya N. M. , Klimov V. T. , Nikolaev V. B. , Dolgova T. M. , Kolesnikova O. B. , Gavrilova O. V. , Kryukova A. V. , Popova Yu. O. , Starikova O. A. , Doroshchenko A. A. , Chesnokova M. V. , Balakhonov S. V. 
Published: March 2023

Background. Pseudotuberculosis remains a serious healthcare problem, which determines the expediency of developing the express methods for its early diagnosis. To detect the pathogen, we designed test system for dot-immunoassay (DIA) based on antibodies labeled with silver nanoparticles (SNPs) isolated from hyperimmune rabbit serum obtained against killed cells of Yersinia pseudotuberculosis of O:1b serovariant.The aim. To assess the possibility of using dot-immunoassay for express identification of Y. pseudotuberculosis cultures isolated from clinical material and environmental objects at the initial stage of bacteriological study during laboratory diagnosis of the disease.Methods. We used the materials from the outbreak of pseudotuberculosis in the Krylovskaya Boarding School of the Bakcharsky district of the Tomsk region in 2021. Specific antibodies from hyperimmune rabbit sera obtained against Y. pseudotuberculosis 3704 particulate antigen of O:1b serotype were labeled with SNPs and used in DIA on nitrocellulose membranes with visualization of reaction results with a solution of a physical developer. The presence of the causative agent of pseudotuberculosis in the test material was inferred by the formation of gray spots of different intensity (from 4+ to 1+).Results. All Y. pseudotuberculosis strains isolated using bacteriological method on the second day of the study from clinical material obtained from sick people and environmental objects were detected in DIA at concentrations ≥ 3.1 × 104 microbial cells per milliliter (m.c./ml).Conclusion. The designed test system for dot-immunoassay using SNPs as a marker of specific antibodies for the detection of Y. pseudotuberculosis in cultures isolated from swabs from vegetables and clinical material from patients, including those with mixed infection, allows us to detect a specific corpuscular antigen with a high sensitivity (≥ 3.1 × 104 m.c./ml), providing express identification of isolated cultures at the initial stage of bacteriological study.
Assessment of the psycho-emotional state of patients after COVID-19-associated pneumonia in relationship with laboratory indicators
Authors: Petelina T. I. , Guskova O. A. , Musikhina N. A. , Shcherbinina A. E. , Garanina V. D. , Gapon L. I. , Yaroslavskaya E. I. 
Published: March 2023

The aim. To study peculiarities and association of psychological and laboratory indicators in patients with cardiovascular diseases (CVD) who underwent COVID-19 to clarify the factors affecting the possibility of developing delayed psychological and cardiovascular adverse events.Methods. The study enrolled 350 patients with COVID-19. Group 1 consisted of 92 patients without CVD, Group 2 – of 258 patients with CVD. Indicators of laboratory and psychological parameters were assessed according to the data of psychological questionnaire using GAD-7 (General Anxiety Disorder-7), PHQ-9 (Patient Health Questionnaire-9), PSS (Perceived Stress Scale) screening scales and SF-36. Parameters of complete blood count and biochemical blood tests were measured during hospitalization and three months after discharge from the monohospital.Results. After three months, in the general group of patients, signs of anxiety and depression were detected in more than 30 % of the examined patients, signs of stress – in 10.4 %. In the group with CVD, psycho-emotional disorders were identified in 1/4 of the patients, and severe stress – in 8 % of those included in the study. In addition, it was registered that the indicators of erythrocyte sedimentation rate, fibrinogen, high-sensitivity C-reactive protein (CRP), homocysteine and IL-6 remained at a higher level in the second group.Correlation analysis showed that the psychological component of health is interconnected with the level of neutrophils (p = 0.044) and fibrinogen (p = 0.050); the physical component of health is correlated with the level of erythrocytes (p = 0.030), hemoglobin (p = 0.015), CRP (p = 0.002), creatine phosphokinase (p = 0.036) and glucose (p = 0.017). Regression analysis revealed that in patients with CVD three months after hospitalization, an increased glucose index contributes to deterioration, and increased hematocrit and mean hemoglobin concentration improve the quality of life of patients.Conclusion. Laboratory markers that maintain the duration of a prolonged vascular reaction, violation of the rheological and metabolic properties of blood, determine the nature of the development of both psychological and cardiovascular complications.
Patients with Laryngeal Disorders Who Undergone Microlaryngeal Surgery at The Dr. Soetomo General Hospital Surabaya
Authors: Priyambodo Yohanes Dimas Pamungkas , Ardani Diar Mia , Perdana Rizka Fathoni 
Published: March 2023

Objective: To describe laryngeal abnormalities undergoing microlaryngeal surgery (MLS). Material and Methods: A retrospective analytical study by examining the central medical record and electronic medical record of patients with laryngeal disorders in the otorhinolaryngology head and neck surgery (ORL-HNS) Outpatient Unit and the Teratai ORL-HNS Surgery Inpatient Care Unit at Dr. Soetomo General Hospital, Surabaya, from January 1 until December 31, 2019, utilizing the chi-square test followed by the Wald test. Results: The number of patient visits from January 1 until December 31, 2019, amounted to 80 patients, most of whom were male and belonged to the 19-60 age group. The histopathology results of patients with neoplasms indicated moderately differentiated squamous cell carcinoma, while the same procedure applied to patients without neoplasms mainly indicated vocal nodules. In this case, the most used technique was a biopsy. Patients with smoking risk factors amounted to 38, while those without smoking risk factors amounted to 42. Conclusion: MLS is used as a means of diagnosis and therapy, including cases of benign and malignant neoplasms.
Strength properties and microstructure of Portland slag cement for well casings under the influence of high temperatures
Authors: Ovchinnikov V. P. , Rozhkova O. V. , Rozhkova D. S. , Listak M. V. 
Published: March 2023

Thermobaric conditions in oil and gas wells require the use of backfill materials with special physical and chemical properties. Cement composites are subject to the requirements of fluidity (to ensure uninterrupted delivery to the cementing site), timely formation of the necessary mechanical strength (to prevent the interaction between the cement glass and reservoir fluids), corrosion resistance, impermeability and durability. Therefore, the composition of the cement slurry should be selected based on the mining and geological characteristics of the well.Wellbores wall are reinforced with protective pipes, which are attached to the well with cement or cement slurry. It is needed to protect wellbores wall from rock falls, gas, oil and water shows and to isolate productive formations. If this operation is carried out qualitatively, then the outer part of the casing string will be protected from the impact of the formation fluid. Otherwise, pipe corrosion may occur, which can lead to the destruction of the cement stone and, as a result, to accidents.
Spinal epidural tuberculoma with osseous involvement: illustrative case
Authors: Cannon Hershel W. , Weaver Michael , Kaul Anand , Lazim Ahmed 
Published: March 2023

BACKGROUND
A tuberculosis infection of the central nervous system can present as a localized, intraspinal tuberculoma. These lesions may cause spinal cord compression requiring early identification and surgical decompression to limit deleterious neurological sequelae.

OBSERVATIONS
A 28-year-old female with a history of opioid use disorder presented with low-back pain in the setting of trauma with progressive bilateral lower extremity radiculopathy and paraparesis. T1- and T2-weighted magnetic resonance imaging sequences of the spine demonstrated a heterogeneously hyperintense extra-axial epidural mass at T11 with mass effect. Biopsy of the lesion revealed benign soft tissue with necrosis and caseating granulomatous inflammation consistent with tuberculoma. The patient underwent laminectomy and debulking of mass for decompression and was subsequently began antitubercular treatment with good neurological outcome.

LESSONS
To the best of the authors’ knowledge, there are only a handful of microbiologically and radiographically confirmed cases of spinal epidural tuberculoma in English literature. These lesions are rare and difficult to clinically and radiographically characterize in the absence of systemic pulmonary TB symptoms. Tuberculoma is an important differential for a spinal epidural mass, particularly because resection with systemic antitubercular treatment results in symptom resolution.
‘Because people here are ignorant’: The failure of a community intervention to prevent mycetoma in Sudan
Authors: Nasr Elsheikh Mohamed , Ackley Caroline , Hall Victoria , Zaman Shahaduz 
Published: March 2023

Background: This study is based on fieldwork conducted amongst a community in Sudan where the neglected tropical disease (NTD), mycetoma, is endemic. In 2018 government officials attempted an unsuccessful intervention and we examine what caused this to fail. This intervention was a collaborative project building animal enclosures, designed specifically to counteract some principal causes of mycetoma, i.e., scratches and cuts common in disease transmission. It was a carefully researched, privately funded, and government-endorsed project, which was almost unequivocally rejected by the community. Methods: Data collection took place in July 2018. Eight interviews and two focus group discussions (FGDs) were conducted with village residents. One FGD was conducted with government officials in charge of the implementation and enforcement of the project; three key-informant interviews with officials from the State Ministry of Health and three interviews with community leaders in the village were conducted, including those responsible for allocation of the new enclosures. The data was analysed using framework analysis. Results: The village residents explained that they didn’t use the enclosures for three reasons: (1) it interferes with the relationship they have with their livestock, (2) the function and design are not practical, and (3) they continually feel let down by government officials. The government officials and representatives from the State Ministry of Health identified two reasons the project failed: (1) ignorance of the people in the village, and (2) poor enforcement. Conclusions: This study shows that government enforcement isn’t a viable intervention to reduce disease burden without considering community ways of life, values, and priorities. We revealed that government officials and villagers have contrasting views on the failure and original necessity of the project. Future behaviour-change interventions need to show respect for different ways of life and the values, beginning with the open facilitation of communication between divergent perspectives.
Immobilization and property of penicillin G acylase on amino functionalized magnetic Ni0.3Mg0.4Zn0.3Fe2O4 nanoparticles prepared via the rapid combustion process
Authors: Ma Mingyi , Chen Xiu , Yue Yao , Wang Jie , He Dawei , Liu Ruijiang 
Published: March 2023

Penicillin G acylase plays an important role in the biocatalytic process of semi-synthetic penicillin. In order to overcome the disadvantages of free enzymes and improve the catalytic performance of enzymes, it is a new method to immobilize enzymes on carrier materials. And magnetic materials have the characteristics of easy separation. In the present study, the Magnetic Ni0.3Mg0.4Zn0.3Fe2O4 nanoparticles were successfully prepared by a rapid-combustion method and calcined at 400°C for 2 h. The surface of the nanoparticles was modified with sodium silicate hydrate, and the PGA was covalently bound to the carrier particles through the cross-linking of glutaraldehyde. The results showed that the activity of immobilized PGA reached 7121.00 U/g. The optimum pH for immobilized PGA was 8 and the optimum temperature was 45°C, the immobilized PGA exhibited higher stability against changes in pH and temperature. The Michaelis–Menten constant (Km) values of the free and immobilized PGA were 0.00387 and 0.0101 mol/L and the maximum rate (Vmax) values were 0.387 and 0.129 μmol/min. Besides, the immobilized PGA revealed excellent cycling performance. The immobilization strategy presented PGA had the advantages of reuse, good stability, cost saving and had considerable practical significance for the commercial application of PGA.