bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influences of Aged Bone Marrow Macrophages on Skeletal Health and Senescence
Authors: Pappert Moritz , Khosla Sundeep , Doolittle Madison 
Published: September 2023

Abstract
Purpose of Review
The purpose of this review is to discuss the role of macrophages in the regulation of skeletal health with age, particularly in regard to both established and unexplored mechanisms in driving inflammation and senescence.

Recent Findings
A multitude of research has uncovered mechanisms of intrinsic aging in macrophages, detrimental factors released by these immune cells, and crosstalk from senescent mesenchymal cell types, which altogether drive age-related bone loss. Furthermore, bone marrow macrophages were recently proposed to be responsible for the megakaryocytic shift during aging and overall maintenance of the hematopoietic niche. Studies on extra-skeletal macrophages have shed light on possible conserved mechanisms within bone and highlight the importance of these cells in systemic aging.

Summary
Macrophages are a critically important cell type in maintaining skeletal homeostasis with age. New discoveries in this area are of utmost importance in fully understanding the pathogenesis of osteoporosis in aged individuals.
Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia
Authors: Wang Ya-Yun , Liu Hui , Li Shu-Jiao , Feng Ban , Huang Yun-Qiang , Liu Shui-Bing , Yang Yan-Ling 
Published: September 2023

AbstractAlthough uncoupling protein 4 (UCP4) is the most abundant protein reported in the brain, the biological function of UCP4 in cerebellum and pathological outcome of UCP4 deficiency in cerebellum remain obscure. To evaluate the role of Ucp4 in the cerebellar Purkinje cells (PCs), we generated the conditional knockdown of Ucp4 in PCs (Pcp2cre;Ucp4fl/fl mice) by breeding Ucp4fl/fl mice with Pcp2cre mice. Series results by Western blot, immunofluorescent staining, and triple RNAscope in situ hybridization confirmed the specific ablation of Ucp4 in PCs in Pcp2cre;Ucp4fl/fl mice, but did not affect the expression of Ucp2, the analog of Ucp4. Combined behavioral tests showed that Pcp2cre;Ucp4fl/fl mice displayed a characteristic bradykinesia in the spontaneous movements. The electromyogram recordings detection excluded the possibility of hypotonia in Pcp2cre;Ucp4fl/fl mice. And the electrical patch clamp recordings showed the altered properties of PCs in Pcp2cre;Ucp4fl/fl mice. Moreover, transmission electron microscope (TEM) results showed the increased mitochondrial circularity in PCs; ROS probe imaging showed the increased ROS generation in molecular layer; and finally, microplate reader assay showed the significant changes of mitochondrial functions, including ROS, ATP, and MMP in the isolated cerebellum tissue. The results suggested that the specific knockdown of mitochondrial protein Ucp4 could damage PCs possibly by attacking their mitochondrial function. The present study is the first to report a close relationship between UCP4 deletion with PCs impairment, and suggests the importance of UCP4 in the substantial support of mitochondrial function homeostasis in bradykinesia. UCP4 might be a therapeutic target for the cerebellar-related movement disorder.
Graphical Abstract
Backbone 1H, 15N and 13C resonance assignments of the 27kDa fluorescent protein mCherry
Authors: Sette Marco , Johnson Laura Anne , Jimenez Ralph , Mulder Frans A.A. 
Published: September 2023

AbstractmCherry is one of the most successfully applied monomeric red fluorescent proteins (RFPs) for in vivo and in vitro imaging. However, questions pertaining to the photostability of the RFPs remain and rational further engineering of their photostability requires information about the fluorescence quenching mechanism in solution. To this end, NMR spectroscopic investigations might be helpful, and we present the near-complete backbone NMR chemical shift assignment to aid in this pursuit.
Impact of nanoscale silicon dioxide coating of stainless-steel surfaces on Listeria monocytogenes
Authors: Hillig Nadja , Schumann-Muck Felicitas , Hamedy Ahmad , Braun Peggy G. , Koethe Martin 
Published: September 2023

AbstractHigh resistance to environmental factors as well as the ability to form biofilms allow Listeria monocytogenes to persist for a long time in difficult-to-reach places in food-producing plants. L. monocytogenes enters final products from contaminated surfaces in different areas of plants and poses a health risk to consumer. Modified surfaces are already used in the food industry to prevent cross-contamination. In this study, stainless-steel surfaces were coated with nanoscale silicon dioxide and the effects on attachment, bacterial growth and detachment of L. monocytogenes were evaluated. Attachment was considered for three different ways of application to simulate different scenarios of contamination. Bacterial growth of L. monocytogenes on the surface was recorded over a period of up to 8 h. Detachment was tested after cleaning inoculated stainless-steel surfaces with heated distilled water or detergent. Coating stainless-steel surfaces with nanoscale silica tends to reduce adherence and increased detachment and does not influence the bacterial growth of L. monocytogenes. Further modifications of the coating are necessary for a targeted use in the reduction of L. monocytogenes in food-processing plants.
Psychedelic-Assisted Psychotherapy and Mindfulness-Based Cognitive Therapy: Potential Synergies
Authors: Chambers Richard , Stoliker Devon , Simonsson Otto 
Published: September 2023

Abstract
Objectives
The mindfulness-informed intervention that has so far received the most attention as an adjunct to psychedelic-assisted psychotherapy is Acceptance and Commitment Therapy (ACT), but little remains known about potential synergies between psychedelic-assisted psychotherapy and mindfulness-based interventions such as Mindfulness-Based Cognitive Therapy (MBCT). This paper examines and evaluates the therapeutic compatibility of MBCT with psychedelic-assisted psychotherapy, and their potential synergies.

Methods
This study represents a narrative review of the current literature on psychedelic-assisted psychotherapy and MBCT.

Results
We demonstrate how MBCT targets core processes including acceptance, being present, concentration, decentering and embracing difficulties — and outline why strengthening these capacities with systematic meditation training may prove invaluable during the preparation, dosing and integration phases of psychedelic-assisted psychotherapy.

Conclusions
MBCT’s emphasis on systematic training in mindfulness meditation and fostering nonjudgmental presence aligns well with the states of consciousness induced by psychedelics, highlighting its potential to enhance various stages of both the psychedelic experience and subsequent integration. By equipping individuals with effective mindfulness and cognitive restructuring techniques, MBCT may offer advantages beyond those provided by ACT, such as the ability to skillfully navigate and manage challenging experiences that can emerge during different phases of the psychedelic experience and integration. This suggests that MBCT’s unique approach may complement psychedelic-assisted psychotherapy in ways that ACT may not fully address, particularly in the context of handling challenging experiences.
The Mindfulness-Based Kindness Curriculum for Preschoolers: An Applied Multi-Site Randomized Control Trial
Authors: Haines Beth A. , Hong Phan Y. , Immel Kathy R. , Lishner David A. 
Published: September 2023

Abstract
Objectives
This study examined the impact of the Mindfulness-Based Kindness Curriculum (MBKC) on social-emotional, executive function, and academic skills of preschoolers.

Method
Sixteen preschool and 4K (4-year-old kindergarten) classrooms (245 children, 57.6% ethnically diverse, 69.8% low SES) were randomly assigned to either a curriculum-as-usual (CAU) or MBKC group taught by trained classroom teachers. Measures, as reported by children, teachers, and parents, were collected prior to and after implementation of the MBKC.

Results
Trained classroom teachers effectively implemented the MBKC. Teachers rated MBKC children significantly higher on outcome measures of social-emotional skills (e.g., sharing, prosocial skills, empathy), executive functioning (e.g., planning/organizing, working memory), and academic skills (e.g., physical development, language, math) than CAU children. Parents rated MBKC children as having significantly higher levels of cognitive empathy compared to parents’ ratings of CAU children. MBKC children were significantly more likely to engage in sharing behavior with a sick child, though children’s self-ratings indicated no effect of the MBKC on mindfulness skills or self-efficacy. Unlike previous research, the MBKC did not benefit initially lower functioning children more than initially higher functioning children.

Conclusions
Consistent with previous research, children given the MBKC appeared to benefit in terms of higher social-emotional competency, prosocial behavior, and executive functioning. The MBKC proved to be a useful complement to their other social-emotional learning programming. The present study expands the literature on the application of mindfulness with preschool children and highlights important implications of teaching and measuring mindfulness skills in young children, thereby identifying specific issues to address in future studies.

Preregistration
This study was not preregistered.
Empty Nose Syndrome: The Case for “Functional Nasal Obstruction” as a Predisposing Risk Prior to Nasal Surgery
Authors: Png Lu Hui , Kalish Larry , Sacks Raymond 
Published: September 2023

Abstract
Purpose of Review
Although empty nose syndrome (ENS) is axiomatically defined post nasal surgery, these patients present to otolaryngologists with complaints of nasal airflow dysfunction preoperatively. The critical question of how to resolve ENS should be in the preoperative assessment rather than focusing on interventions post nasal surgery. There are no proven factors from surgery that predict ENS post turbinate surgery. We review the latest literature on ENS and evaluate developing trends in the understanding of its pathophysiology and associations. This review seeks to develop a modern approach to the management of this recalcitrant condition.

Recent Findings
Recent literature on ENS suggests possible psychogenic etiologies and associations, providing an avenue for treatment strategies. Previous theories of ENS pathogenesis regarding extent of turbinate surgery are not supported by airflow and radiologic assessments. Premorbid neurosensory alterations may explain why some patients, often with mental health comorbidities, present for nasal surgery without significant clinical findings and is a patient population predisposed to ENS.

Summary
The concept of “functional nasal obstruction” or FNO, needs to become a diagnostic option for the clinician when assessing patients for nasal surgery. Patients identifying with ENS may be a population of patients with functional nasal obstruction, unrecognized and now after surgical efforts to relieve symptoms. The disorder underlying ENS should be considered an unrecognized risk factor in patient selection “prior” to nasal surgery rather than a postoperative complication “from” nasal surgery. Identifying this risk factor preoperatively is critical in avoiding subsequent morbidity. Further research into identifying “functional nasal obstruction” prior to nasal surgery should be undertaken as a priority over interventions after the ENS condition occurs.
Effects of mealtime assistance in the nutritional rehabilitation of eating disorders
Authors: Lacalaprice Doriana , Mocini Edoardo , Frigerio Francesco , Minnetti Marianna , Piciocchi Claudia , Donini Lorenzo Maria , Poggiogalle Eleonora 
Published: September 2023

Abstract
Purpose
The aim of the study was to examine the effects of meal supervision, provided by health professionals, volunteers or family members, on anthropometric, nutritional, psychological, and behavioural outcomes in patients with eating disorders (EDs).

Methods
The present systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The last search was conducted in three databases (PubMed, Scopus, and the Cochrane library). Inclusion criteria considered paediatric and adult patients suffering from EDs, regardless of ethnicity, and treated in different therapeutic settings. The quality of the studies was evaluated using the Newcastle Ottawa Scale (NOS) adapted for cross-sectional studies and Version 2 of the Cochrane risk-of-bias assessment tool for randomised trials.

Results
3282 articles were retrieved, out of which only 6 met the eligibility criteria. A marked heterogeneity in definitions and approaches to supervised mealtime was observed. This variability emerged in the methodologies used in the supervised meal, and in the reference values for the outcome measures that were used, such as the analysis of different parameters.
Based on these observations, mealtime assistance provided to patients with EDs shows an overall positive effect on eating behaviour and dysfunctional attitudes. Future research should be prompted to provide a thorough definition of a structured procedure for meal assistance to be potentially and systematically included in the nutritional rehabilitation protocols for patients with EDs.

Level of evidence
Level IV systematic reviews of uncontrolled trials.
How did organ donation in Israel become a club membership model? From civic to communal solidarity in organ sharing
Authors: Boas Hagai 
Published: September 2023

AbstractFiguring out what pushes individuals to become organ donors has become the holy grail of social scientists interested in transplantations. In this paper I concentrate on solidarity as a determinant of organ donation and examine it through the history of organ donation in Israel. By following the history of transplantation policies since 1968 and examining them in relation to different types of solidarities, this paper leads to a nuanced understanding of the ties between solidarity and health policy. Attempts to foster an all-encompassing consensus on the definition of brain death yielded the Transplantation and the Brain-Respiratory Death Laws of 2008. It was hoped that a wide “civic solidarity” would render Israel self-sufficient in its organ economy. However, the failure of the law led to the breakdown of civic solidarity in organ donation. As a result, initiatives such as the priority policy and non-directed living organ donations, developed out of a narrower conception of solidarity. Juxtaposing these initiatives sheds light on macro level processes for policy makers and suggests solidarity as a key bioethical concept to understand organ donation policies.
Standardized, risk-adapted induction therapy in kidney transplantation
Authors: Eisinger Felix , Mühlbacher Thomas , Na Ario , Althaus Karina , Nadalin Silvio , Birkenfeld Andreas L. , Heyne Nils , Guthoff Martina 
Published: September 2023

Abstract
Background
The choice of induction therapy in kidney transplantation is often non-standardized and centre-specific. Clinicians can choose between depleting and non-depleting antibodies, which differ in their immunosuppressive capacity and the concomitant risk of infection. We herein present a standardized risk-stratified algorithm for induction therapy that might help to balance the risk of rejection and/or serious infection.

Methods
Prior to kidney transplantation, patients were stratified into low-risk, intermediate-risk or high-risk according to our protocol based on immunologic risk factors. Depending on their individual immunologic risk, patients received basiliximab (low risk), antithymocyte globulin (intermediate risk) or low-dose alemtuzumab (high risk) for induction therapy. We analysed the results after 3 years of implementation of our risk-stratified induction therapy protocol at our kidney transplant centre.

Results
Between 01/2017 and 05/2020, 126 patients were stratified in accordance with our protocol (low risk/intermediate risk/high risk: 69 vs. 42 vs. 15 patients). The median follow-up time was 1.9 [1.0–2.5] years. No significant difference was observed in rejection rate and allograft survival (low risk/intermediate risk/high risk: 90.07% vs. 80.81% vs. 100% after 3 years (p > 0.05)) among the groups. The median eGFR at follow-up was (low risk/intermediate risk/high risk) 47 [33–58] vs 58 [46–76] vs 44 [22–55] ml/min/1.73 m2. Although the rate of viral and bacterial infections did not differ significantly, we observed a higher rate of opportunistic fungal infections with alemtuzumab induction.

Conclusions
Our strategy offers facilitated and individualized choice of induction therapy in kidney transplantation. We propose further evaluation of our algorithm in prospective trials.
A Hybrid Similarity-Based Method for Wind Monitoring System Deployment Optimization Along Urban Railways
Authors: Zhao Wenqiang , Zhang Zhipeng , Hou Bowen , Huang Yujie , Xie Ye 
Published: September 2023

AbstractUrban railways in coastal areas are exposed to the risk of extreme weather conditions. A cost-effective and robust wind monitoring system, as a vital part of the railway infrastructure, is essential for ensuring safety and efficiency. However, insufficient sensors along urban rail lines may result in failure to detect local strong winds, thus impacting urban rail safety and operational efficiency. This paper proposes a hybrid method based on historical wind speed data analysis to optimize wind monitoring system deployment. The proposed methodology integrates warning similarity and trend similarity with a linear combination and develops a constrained quadratic programming model to determine the combined weights. The methodology is demonstrated and verified based on a real-world case of an urban rail line. The results show that the proposed method outperforms the single similarity-based method and spatial interpolation approach in terms of both evaluation accuracy and robustness. This study provides a practical data-driven tool for urban rail operators to optimize their wind sensor networks with limited data and resources. It can contribute significantly to enhancing railway system operational efficiency and reducing the hazards on rail infrastructures and facilities under strong wind conditions. Additionally, the novel methodology and evaluation framework can be efficiently applied to the monitoring of other extreme weather conditions, further enhancing urban rail safety.
Characterisation of print path deviation in material extrusion
Authors: Sherugar Shivdarshan , Birkett Martin , Blacklock Matthew 
Published: September 2023

AbstractMaterial extrusion, also known as fused filament fabrication, is one of the most popular additive manufacturing techniques due to its lower cost and ease of handling. However, parts produced by material extrusion have relatively poor mechanical performance, dimensional accuracy and thermal performance as compared to parts produced by subtractive manufacturing due to high void content. Previous studies have suggested print path deviation as the cause of these voids, but no attempt has yet been made to characterise these deviations. In this study, we propose a method to assess print path deviation for material extrusion that may reduce the formation of voids in printed parts. Geometric features including straight paths, various angled corners and curves of varying radii are printed at different print speeds using an open-source printer and then imaged under a microscopic. The deviation in print path centroid and width is classified as being a combination of systematic and stochastic deviations. Systematic deviation is determined by the difference between the mean of the actual print path and the ideal print path sent to the printer by the user. Stochastic deviation represents the randomness across print samples and is given by the root mean square deviation. The relationship between stochastic deviation between any two points along the print path is determined by a correlation coefficient. The results show that both print speed and different geometric print features affect the amount of deviation in the print path. In the case of correlation of the stochastic deviation along print paths, geometric features are found to have a much greater effect than print speed. The proposed method provides a low cost and highly transferrable technique to characterise the print path deviation within material extrusion parts with respect to varying printing parameters. An accurate understanding of local print deviations within a part plays a major role in the analysis and topology optimisation of 3D printed parts and gives the ability to assess the print quality and identify the root cause of print deviations, thus reducing voids and improving mechanical performance, dimensional accuracy and thermal properties of the printed part.
An Efficient Keywords Search in Temporal Social Networks
Authors: Ge Youming , Chen Zitong , Liu Yubao 
Published: September 2023

AbstractWith the increasing of requirements from many aspects, various queries and analyses arise focusing on social network. Time is a common and necessary dimension in various types of social networks. Social networks with time information are called temporal social networks, in which time information can be the time when a user sends message to another user. Keywords search in temporal social networks consists of finding relationships between a group users that has a set of query labels and is valid within the query time interval. It provides assistance in social network analysis, classification of social network users, community detection, etc. However, the existing methods have limitations in solving temporal social network keyword search problems. We propose a basic algorithm, the discrete timestamp algorithm, with the intention of turning the problem into a traditional keyword search on social networks. We also propose an approximative algorithm based on the discrete timestamp algorithm, but it still suffers from the traditional algorithms’ low efficiency. To further improve the performance, we propose a new algorithm based on dynamic programming to solve the keyword search in temporal social network. The main idea is to extend a vertex into a solution by edge-growth operation and tree-merger operation. We also propose two powerful pruning techniques to reduce the intermediate results during the extension. Additionally, all of the algorithms we proposed are capable of handling a variety of ranking functions, and all of them can be made to conform to top-N keyword querying. The efficiency and effectiveness of the proposed algorithms are verified through extensive empirical studies.