bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous healing of a ruptured anterior cruciate ligament: a case series and literature review
Authors: Previ Leonardo , Monaco Edoardo , Carrozzo Alessandro , Fedeli Gianluca , Annibaldi Alessandro , Cantagalli Matteo Romano , Rossi Giorgio , Ferretti Andrea 
Published: February 2023

PurposeThe anterior cruciate ligament is probably one of the ligaments with the lowest healing potential. Many authors have reported cases of spontaneous healing but nowadays it is difficult to predict successful healing of an anterior cruciate ligament rupture and, even more, residual functionality and capability to return to sport. The aim of this study was to investigate cases of spontaneous healing in a population that received non‐surgical treatment after anterior cruciate ligament rupture and to perform an updated review of contemporary literature.MethodsThe authors retrospectively reviewed patients who suffered from an acute complete anterior cruciate ligament rupture and underwent non‐surgical treatment. No specific rehabilitation protocol was prescribed. A new magnetic resonance imaging study was conducted 6 months after the injury for all patients. A literature review was conducted regarding spontaneous healing of the anterior cruciate ligament. The papers included in the analysis were reports of any level of evidence, written in English, Italian, or French languages; articles were excluded if they reported non‐human studies, histological studies, studies conducted without magnetic resonance imaging or arthroscopic second look, or partial anterior cruciate ligament tear.ResultsCase series: Six patients were enrolled in the study. All patients had a proximal anterior cruciate ligament lesion. The minimum follow‐up was 13 months (range 6–20 months). At the last follow‐up the mean score on the Lysholm scale was 97, the mean IKDC score was 94, and the mean KOOS score was 96. All patients returned to their own sport activities; no one reported significant differences. The magnetic resonance imaging study at 6 months revealed an end‐to‐end continuous anterior cruciate ligament with homogeneous signal. No one had any new knee injury at last follow‐up. Literature review: A search of comprehensive databases retrieved 1057 articles; 8 full‐text articles met the eligibility criteria. The studies were heterogeneous regarding the populations analysed, sport activity level, treatment applied, healing definition, and follow‐up. The failure rate of non‐surgical management ranged among the papers from 0 to 73%.ConclusionsThe study findings show that spontaneous anterior cruciate ligament healing is possible and there are chances of clinical recovery for patients not suitable for surgery. However, there is still a lack of evidence about predictors, clinical outcomes, and adequate rehabilitation protocols.
Reduced contrast sensitivity function correlated with superficial retinal capillary plexus impairment in early stage of dysthyroid optic neuropathy
Authors: Tu Yunhai , Jin Haochen , Xu Mingna , Liu Weijie , Hu Xiaozhou , Wang Mengting , Ye Jie , Liu Zihui , Gao Mengyuan , Hou Fang , Lu Zhong-Lin , Wu Wencan 
Published: February 2023

Abstract
Background
To assess the accuracy of contrast sensitivity function (CSF) in detecting dysthyroid optic neuropathy (DON) at an early stage in thyroid-associated ophthalmopathy (TAO) patients and to examine potential factors that may be linked to early visual impairments in these individuals.

Methods
A total of 81 TAO patients (50 non-DON and 31 DON), and 24 control subjects participated in the study. CSF was measured with the quick CSF (qCSF) method. Optical coherence tomography angiography (OCTA) images of the ganglion cell complex layer (GCCL), superficial and deep retinal capillary plexuses (SRCP and DRCP) in a 3 mm diameter area around the macula were evaluated.

Results
Compared with the controls, the area under the log contrast sensitivity function (AULCSF) and SRCP density were significantly reduced in non-DON and DON patients (all P < 0.05). The GCCL thickness of the DON patients was thinner than that of the controls and non-DON patients (all P < 0.05). The AULCSF was significantly correlated with spherical equivalent refractive error, muscle index, SRCP density and GCCL thickness in TAO patients, respectively (all P < 0.05). However, stepwise multi-regression analysis showed that the AULCSF was only significantly correlated with SRCP density (P < 0.001). Receiver operating characteristic curve analysis showed that the AULCSF produced the most accurate discrimination between non-DON and DON patients from the controls (AUC = 0.831, 0.987, respectively; all P < 0.001).

Conclusions
CSF change in the early stage of DON is related to SRCP density. It can be an early indicator of visual impairments associated with DON in TAO patients.
Analysis of spatial distribution of landslides triggered by the Ms 6.8 Luding earthquake in China on September 5, 2022
Authors: Xiao Zikang , Xu Chong , Huang Yuandong , He Xiangli , Shao Xiaoyi , Chen Zhaoning , Xie Chenchen , Li Tao , Xu Xiwei 
Published: February 2023

Abstract
Background
On September 5, 2022, an Ms 6.8 earthquake occurred in Luding County, Ganzi Tibetan Autonomous Prefecture, Sichuan, China. The casualties and economic losses caused by the earthquake are huge. Most of the landslides triggered by this earthquake are small and medium-sized rock collapses and destructive debris flows, with a small number of large-scale landslides.

Results
There are 5007 coseismic landslides in the Luding earthquake VII-degree area and above, with a total area of 17.36 km2. The landslides are generally distributed along the NW-SE direction. The highest landslide area density is 13.8%, and the highest point density of the landslide is 35.73 km2. High-density area is mainly concentrated in the IX-degree area and the northeast side of the seismogenic fault. Coseismic landslides are more likely to develop in the area with the slope more than 40°, the slope direction of 67.5-112.5 degree, and vegetation coverage of 40–50%. More landslides are developed in granite areas and forest areas. The closer distance to active faults, the more the coseismic landslides develop. The correlation between coseismic landslide development and the distance from the active faults is better than that between coseismic landslide development and the distance from the seismogenic faults.

Conclusion
The landslide database used in this paper is the most perfect at present, and the research results have also been verified by fieldwork. This is also the first applied study of this landslide inventory, which indirectly confirmed the accuracy of the inventory. The results obtained in the manuscript will provide an important guideline for future
disaster prevention and mitigation in southwest China.
Effects and Optimal Dose of Exercise on Endothelial Function in Patients with Heart Failure: A Systematic Review and Meta-Analysis
Authors: Fuertes-Kenneally Laura , Manresa-Rocamora Agustín , Blasco-Peris Carles , Ribeiro Fernando , Sempere-Ruiz Noemí , Sarabia José Manuel , Climent-Paya Vicente 
Published: February 2023

Abstract
Background
Exercise-based cardiac rehabilitation (CR) is considered an effective treatment for enhancing endothelial function in patients with heart failure (HF). However, recent studies have been published and the optimal “dose” of exercise required to increase the benefits of exercise-based CR programmes on endothelial function is still unknown.

Objectives
(a) To estimate the effect of exercise-based CR on endothelial function, assessed by flow-mediated dilation (FMD), in patients with HF; (b) to determine whether high-intensity interval training (HIIT) is better than moderate-intensity training (MIT) for improving FMD; and (c) to investigate the influence of exercise modality (i.e. resistance exercise vs. aerobic exercise and combined exercise vs. aerobic exercise) on the improvement of endothelial function.

Methods
Electronic searches were carried out in PubMed, Embase, and Scopus up to February 2022. Random-effects models of between-group mean differences were estimated. Heterogeneity analyses were performed by means of the chi-square test and I2 index. Subgroup analyses and meta-regressions were used to test the influence of potential moderator variables on the effect of exercise.

Results
We found a FMD increase of 3.09% (95% confidence interval [CI] = 2.01, 4.17) in favour of aerobic-based CR programmes compared with control groups in patients with HF and reduced ejection fraction (HFrEF). However, the results of included studies were inconsistent (p < .001; I2 = 95.2%). Higher FMD improvement was found in studies which were randomised, reported radial FMD, or performed higher number of training sessions a week. Moreover, HIIT enhanced FMD to a greater extent than MIT (2.35% [95% CI = 0.49, 4.22]) in patients with HFrEF. Insufficient data prevented pooled analyses for the effect of exercise in patients with HF and preserved ejection fraction and the influence of exercise modality on the improvement of endothelial function.

Conclusion
Aerobic-based CR is a non-pharmacological treatment for enhancing endothelial function in patients with HFrEF. However, higher training frequency and HIIT induce greater adaptation of endothelial function in these patients, which should betaken into consideration when designing exercise-based CR programmes.
Trial registration The protocol was prospectively registered on the PROSPERO database (CRD42022304687).
Then there were seven: a commentary on creating a public involvement strategy group for a policy research unit in behavioural science
Authors: Green Dave , Bryant Val , Edwards Stuart , Kemp Caroline , McKenzie Maisie , Shah Sudhir , Soulsby Irene 
Published: February 2023

AbstractThe National Institute for Health and Care Research (NIHR) Policy Research Unit in Behavioural Science (PRU-BS) was funded to inform government on the application of behavioural science in health and social care policy. What makes this unit different to other topic specific ones, was the wide range of its brief. Because of this, the PPI group would need to include a wide range of experience and expertise and be prepared to learn. We were a different type of public group for a different type of task. This paper deals with how we approached this. In this paper we outline how the PPI plan in the funding proposal for the PRU-BS was adapted to real world challenges. We describe the stages in the formation of the PPI Strategy Group and how a virtual platform was created to ensure good communication. We discuss our pragmatic approach of developing Terms of Reference and a PPI strategy document. Given the restrictions imposed by the Covid-19 pandemic we explain how we tackled PPI SG member induction sessions, meetings and training sessions. To illustrate how the group operates we provide an example of our involvement in a PRU-BS project. Central to our paper is the lessons we learned. We hope the challenges we met in forming the unique PPI SG, how these were overcome, and our recommendations will help others faced with a similar task.
Gut microbiome diversity and composition is associated with exploratory behavior in a wild-caught songbird
Authors: Florkowski Melanie R. , Yorzinski Jessica L. 
Published: February 2023

Abstract
Background
The gut microbiome influences its host in a myriad of ways, from immune system development to nutrient utilization. However, our understanding of the relationship between the gut microbiome and behavior, especially in wild species, is still poor. One behavior that potentially interacts with the gut microbiome is exploratory behavior, which animals use to acquire new information from the environment. We hypothesized that diversity of the gut microbiome will be correlated with exploratory behavior in a wild-caught bird species. To test this hypothesis, we captured wild house sparrows (Passer domesticus) and collected fecal samples to measure the diversity of their gut microbiomes. We then introduced individuals to a novel environment and measured their exploratory behavior.

Results
We found that birds with higher alpha diversity of the gut microbiome exhibited higher exploratory behavior. These results suggest that high exploratory birds encounter more types of environmental microbes that contribute to their diverse gut microbiome compared with less exploratory birds. Alternatively, increased gut microbiome diversity may contribute to increased exploratory behavior. We also found differences in beta diversity when comparing high and low exploring birds, indicating differences in microbiome community structure. When comparing predicted functional pathways of the birds’ microbiomes, we found that the microbiomes of high explorers contained more pathways involved in biofilm formation and xenobiotic degradation than those of low explorers.

Conclusions
Overall, we found that the alpha and beta diversity of the gut microbiome is correlated with exploratory behavior of house sparrows. The predicted functions of the gut microbiome from high explorers differs from that of low explorers. Our study highlights the importance of considering the gut microbiome when investigating animal behavior.
The fecal bacterial microbiome of the Kuhl’s pipistrelle bat (Pipistrellus kuhlii) reflects landscape anthropogenic pressure
Authors: Lobato-Bailón Lourdes , García-Ulloa Manuel , Santos Andrés , Guixé David , Camprodon Jordi , Florensa-Rius Xavier , Molleda Raúl , Manzano Robert , P. Ribas Maria , Espunyes Johan , Dias-Alves Andrea , Marco Ignasi , Migura-Garcia Lourdes , Martínez-Urtaza Jaime , Cabezón Oscar 
Published: February 2023

Abstract
Background
Anthropogenic disturbance has the potential to negatively affect wildlife health by altering food availability and diet composition, increasing the exposure to agrochemicals, and intensifying the contact with humans, domestic animals, and their pathogens. However, the impact of these factors on the fecal microbiome composition of wildlife hosts and its link to host health modulation remains barely explored. Here we investigated the composition of the fecal bacterial microbiome of the insectivorous bat Kuhl’s pipistrelle (Pipistrellus kuhlii) dwelling in four environmental contexts with different levels of anthropogenic pressure. We analyzed their microbiome composition, structure and diversity through full-length 16S rRNA metabarcoding using the nanopore long-read sequencer MinION™. We hypothesized that the bacterial community structure of fecal samples would vary across the different scenarios, showing a decreased diversity and richness in samples from disturbed ecosystems.

Results
The fecal microbiomes of 31 bats from 4 scenarios were sequenced. A total of 4,829,302 reads were obtained with a taxonomic assignment percentage of 99.9% at genus level. Most abundant genera across all scenarios were Enterococcus, Escherichia/Shigella, Bacillus and Enterobacter. Alpha diversity varied significantly between the four scenarios (p < 0.05), showing the lowest Shannon index in bats from urban and intensive agriculture landscapes, while the highest alpha diversity value was found in near pristine landscapes. Beta diversity obtained by Bray–Curtis distance showed weak statistical differentiation of bacterial taxonomic profiles among scenarios. Furthermore, core community analysis showed that 1,293 genera were shared among localities. Differential abundance analyses showed that the highest differentially abundant taxa were found in near pristine landscapes, with the exception of the family Alcaligenaceae, which was also overrepresented in urban and intensive agriculture landscapes.

Conclusions
This study suggests that near pristine and undisturbed landscapes could promote a more resilient gut microbiome in wild populations of P. kuhlii. These results highlight the potential of the fecal microbiome as a non-invasive bioindicator to assess insectivorous bats’ health and as a key element of landscape conservation strategies.
Erdheim-Chester disease associated with an aggressive form of sclerosing cholangitis
Authors: Sharma Ruchi , Stone Mary S. , Macfarlane Donald E. , Bellizzi Andrew M. , Koneru Gopala 
Published: February 2023

Abstract
Background
Erdheim-Chester disease (ECD) is a rare histiocytic disorder recently recognized as a neoplasm due to the discovery of activating MAPK pathway mutations. Hepatic involvement by ECD is extremely rare.

Case presentation
We describe a case of a 64-year-old male who presented with pruritis, weight loss, and cholestatic liver function tests. Magnetic resonance imaging of the abdomen showed beaded appearance of the intrahepatic biliary tree. A liver biopsy was suggestive of primary or secondary sclerosing cholangitis. Computerized tomography (CT) of the abdomen showed perinephric and periaortic soft tissue stranding suggestive of ECD. 18F-fluorodeoxyglucose positron emission/computerized tomography scan showed a mediastinal hilar mass which turned out to be follicular lymphoma. Histopathology of molluscum-like skin lesions showed CD68 + , Factor XIIIa + , and CD1a-foamy histiocytes with multiple giant cells suggestive of ECD. The patient developed recurrent episodes of ascending cholangitis and his hyperbilirubinemia continued to worsen despite stenting of a common hepatic duct stricture found on endoscopic retrograde cholangiopancreatography.

Conclusions
The absence of associated inflammatory bowel disease and anti-neutrophil cytoplasmic antibody, as well as the rapidity of disease progression, makes us consider the possibility of hepatic involvement by ECD or an overlap syndrome. We want to highlight that negative histopathology should not delay the diagnosis of ECD as effective and potentially lifesaving therapies with BRAF or MEK pathway inhibitors are now available for these patients.
Brown Theory: A Storied Manifest of Our World
Authors: Patterson Christopher B. 
Published: February 2023

Abstract
This article conceives of a transpacific brownness in relation to other forms of brown to produce a storied manifest for brown theory. By activating “the brown transpacific” as an epistemological paradigm that navigates the disciplinary logics of colonial encounters, this article attempts to untangle a story of how some people in Asia went from resembling a wild and uncontainable threat to a form of brownness that became necessary for the reproduction of the Global North. As the last “color” term to be used by racial scientists, “brownness” has delineated racial hierarchies between blackness and whiteness that, to colonial powers, have emphasized the possible degradation of whiteness, or, to the colonized, have promised future induction into whiteness. The varied formations of transpacific brownness explored showcase the impossibility of its own capture—rather than reveal a bounded history, brownness arrives as a concept that cannot be grasped or produced into knowledge. This article thus shifts in its second half from its focus on the “brown transpacific” to a theoretical triptych that reflects on brownness as (1) a site for the ungovernable “brown mass,” (2) peoples marked for domestication through strategies of colonial containment, and (3) the complex “shades” that reveal troubling histories and shameful intimacies.
Deleuze and East Asia: Toward a Comparative Methodology of the Gap
Authors: Hetrick Jay 
Published: February 2023

Abstract
This article discusses the significance of Gilles Deleuze's almost passing references to East Asian thought. Even though Deleuze comes to these ideas through the work of other European thinkers—most notably Friedrich Nietzsche, Sergei Eisenstein, François Jullien, and Alan Watts—the article argues that there are ultimately deep resonances between Deleuze's philosophy, especially in its Bergso-Leibnizian articulations, and specific East Asian ideas. The article begins by cataloging and commenting upon Deleuze's various references to Chinese and Japanese thought generally before discussing how one particular concept—that of the gap (écart)—not only lies at the heart of his metaphysics but also forms the very basis for developing an adequate methodology for negotiating his encounter with East Asia. Finally, by also considering some of Jullien's recent ideas, the article examines the ways in which this methodology of the gap may be more adequate than other attempts to characterize contemporary comparative philosophy.
Paris in Korean Cinema: Fraudulence and the Female Form in Hong Sang-soo's Night and Day and Kim Ki-duk's Wild Animals
Authors: Choe Youngmin 
Published: February 2023

Abstract
This article explores how and why fraudulence and deception get coded as feminine in Korean politics and popular culture. Focusing on the processes whereby deception gets conflated with the female body, it examines filmic articulations of physical and rhetorical attacks—ranging from subtle to overt—against works of art about the female body, in which aesthetic judgments take on a moral character. The article begins with a discussion of Kim Soyoung's new woman: her first song (2004), which locates the possibilities for subject formation that the figure of the new Korean woman exemplifies in deformations, ruptures and breakages. The article then turns to a pair of films, Hong Sang-soo's Night and Day (2007) and Kim Ki-duk's Wild Animals (1997), which explore the threat and possibilities that such a model of feminine subjectivity offers. The article then closes by way of reference to Jeon Soo-il's A Korean in Paris (2015), in which the possibility of formless subjectivity becomes disavowed within a paranoid vision of the new Korean woman as a fraud. In all of these films, the misogynist tendencies within contemporary Korean society are specifically displaced onto the distant location of Paris, which is not coincidentally regarded as the origin point of the new Korean woman. Generally, in Korean cinema, Paris has been featured both as a site of authenticity and formal experimentation in art and also as the scene of sexual awakening for women. The films discussed in this article foreground questions of aesthetic style around the figure of the female body, and in the process, the female subject's engagement to art becomes conflated with and assessed by questions of morality, becoming divorced from the more relevant aesthetic contexts.