bluuebunny/crossref_metadata_2025_split huggingface dataset:
Language and face in interactions: emotion perception, social meanings, and communicative intentions
Authors: Liu Mingya , Schwab Juliane , Hess Ursula 
Published: May 2023

IntroductionHuman emotions can be complex to interpret as they have multiple sources and are often times ambiguous, for example, when the signals sent by different channels of communication are inconsistent. Our study investigates the interaction of linguistic and facial expressions of emotions.MethodsIn two experiments, participants read short scenarios in German containing a direct utterance with positive or negative emotive markers, in combination with different facial expressions as still images of the speaker (i.e., the protagonist in the story). They answered questions about their perception regarding the intensity of the emotions (e.g., happiness, sadness), the properties of the expresser (e.g., honesty, warmth, likeability) and their relation to the addressee (e.g., closeness), as well as the expresser intention (e.g., irony, joke).ResultsThe findings suggest that facial expressions have a more dominant role in the emotion perception in comparison to emotive markers. Furthermore, consistent and inconsistent combinations of emotive markers and facial expressions convey distinct social meanings and communicative intentions.ConclusionThis research points to the importance to consider emotive markers in the emotional context that they occur in.
Chronic pain and problematic substance use for veterans during COVID-19: the moderating role of psychological flexibility
Authors: Reilly Erin D. , Wolkowicz Noah R. , Heapy Alicia , Ross MacLean R. , Duarte Brooke A. , Chamberlin Elizabeth S. , Harris J. Irene , Shirk Steven D. , Kelly Megan M. 
Published: May 2023

BackgroundChronic pain and problematic substance use are commonly co-occurring and highly detrimental issues that are especially prevalent in U.S. veteran populations. Although COVID-19 made clinical management of these conditions potentially difficult, some research suggests that certain veterans with these conditions did not experience this period as negatively as others. It is thus important to consider whether resilience factors, such as the increasingly-studied process of psychological flexibility, might have led to better outcomes for veterans managing pain and problematic substance use during this time of global crisis.MethodsThis planned sub-analysis of a larger cross-sectional, anonymous, and nationally-distributed survey (N = 409) was collected during the first year of the COVID-19 pandemic. Veteran participants completed a short screener and battery of online surveys assessing pain severity and interference, substance use, psychological flexibility, mental health functioning, and pandemic-related quality of life.ResultsFor veterans with chronic pain and problematic substance use, the pandemic resulted in a significant lowering of their quality of life related to meeting basic needs, emotional health, and physical health compared to veterans with problematic substance use but no chronic pain diagnosis. However, moderation analyses revealed that veterans with these comorbid conditions experienced less negative impacts from the pandemic on quality of life and mental health when they reported greater psychological flexibility. For veterans with problematic substance use only, psychological flexibility was also related to better mental health functioning, but did not significantly correlate with their quality of life.ConclusionResults highlight how COVID-19 differentially impacted veterans with both problematic substance use and chronic pain, such that this group reported particularly negative impacts of the pandemic on multiple areas of quality of life. However, our findings further emphasize that psychological flexibility, a modifiable resiliency process, also buffered against some of the negative impacts of the pandemic on mental health and quality of life. Given this, future research into the impact of natural crises and healthcare management should investigate how psychological flexibility can be targeted to help increase resiliency for veterans with chronic pain and problematic substance use.
Genetic and neural mechanisms of sleep disorders in children with autism spectrum disorder: a review
Authors: Ji Qi , Li Si-Jia , Zhao Jun-Bo , Xiong Yun , Du Xiao-Hui , Wang Chun-Xiang , Lu Li-Ming , Tan Jing-Yao , Zhu Zhi-Ru 
Published: May 2023

BackgroundThe incidence of sleep disorders in children with autism spectrum disorder (ASD) is very high. Sleep disorders can exacerbate the development of ASD and impose a heavy burden on families and society. The pathological mechanism of sleep disorders in autism is complex, but gene mutations and neural abnormalities may be involved.MethodsIn this review, we examined literature addressing the genetic and neural mechanisms of sleep disorders in children with ASD. The databases PubMed and Scopus were searched for eligible studies published between 2013 and 2023.ResultsProlonged awakenings of children with ASD may be caused by the following processes. Mutations in theMECP2, VGATandSLC6A1genes can decrease GABA inhibition on neurons in the locus coeruleus, leading to hyperactivity of noradrenergic neurons and prolonged awakenings in children with ASD. Mutations in theHRH1, HRH2, andHRH3genes heighten the expression of histamine receptors in the posterior hypothalamus, potentially intensifying histamine’s ability to promote arousal. Mutations in theKCNQ3andPCDH10genes cause atypical modulation of amygdala impact on orexinergic neurons, potentially causing hyperexcitability of the hypothalamic orexin system. Mutations in theAHI1,ARHGEF10,UBE3A, andSLC6A3genes affect dopamine synthesis, catabolism, and reuptake processes, which can elevate dopamine concentrations in the midbrain. Secondly, non-rapid eye movement sleep disorder is closely related to the lack of butyric acid, iron deficiency and dysfunction of the thalamic reticular nucleus induced byPTCHD1gene alterations. Thirdly, mutations in theHTR2A, SLC6A4,MAOA, MAOB,TPH2,VMATs,SHANK3,andCADPS2genes induce structural and functional abnormalities of the dorsal raphe nucleus (DRN) and amygdala, which may disturb REM sleep. In addition, the decrease in melatonin levels caused byASMT,MTNR1A, andMTNR1Bgene mutations, along with functional abnormalities of basal forebrain cholinergic neurons, may lead to abnormal sleep–wake rhythm transitions.ConclusionOur review revealed that the functional and structural abnormalities of sleep–wake related neural circuits induced by gene mutations are strongly correlated with sleep disorders in children with ASD. Exploring the neural mechanisms of sleep disorders and the underlying genetic pathology in children with ASD is significant for further studies of therapy.
A case study of group art therapy using digital media for adolescents with intellectual disabilities
Authors: Kim Jinkyung , Chung Yeo Ju 
Published: May 2023

IntroductionIn art therapy, digital art therapy is a new method in which clients use digital media to express themselves creatively. We wanted to explore what this means for adolescents with disabilities. The purpose of this qualitative case study was to explain what kind of experience they had when digital media was applied as an expressive and therapeutic medium in group art therapy in which adolescents with intellectual disabilities were participants and what kind of therapeutic meaning the experience had. We tried to know the therapeutic factors by extracting the implications of meaning.MethodsParticipants were second-year high school students with intellectual disabilities who belonged to special classes. They were selected in an intentional purposive sampling method. Five teenagers with intellectual disabilities participated in 11 group art therapy sessions. Data were collected through interviews, observation, and digital artwork collection. Collected data were case studies analyzed using an inductive approach. In this study, the use of digital media was defined and utilized as “Digital Art Therapy” by setting the scope related to the study according to client’s behavioral method.ResultsAs a digital generation accustomed to smartphones, the participants gained confidence by repeatedly acquiring new technologies through familiarity with the media. Interaction with the media through touch and the use of apps have promoted autonomy with interest and pleasure to disabled teenagers, allowing them to express themselves actively. In particular, digital art therapy induces a holistic sensory experience by mobilizing visual images that could represent various expressions, emotions felt in music and tactile senses that made texts for people with intellectual disabilities with difficulty in verbal communication.DiscussionArt therapy using digital media has become an important experience that provides opportunities to arouse curiosity, enjoy creative activities, and express positive emotions vividly to adolescents with intellectual disabilities who have difficulties with expression and communication and a sense of lethargy. Therefore, it is suggested that an in-depth understanding of the characteristics and differences between traditional and digital media is necessary, and that complementary use to help create therapeutic purposes and art therapy is important.
Neuroimaging findings in preclinical amyotrophic lateral sclerosis models—How well do they mimic the clinical phenotype? A systematic review
Authors: Cannon Amelia Elaine , Zürrer Wolfgang Emanuel , Zejlon Charlotte , Kulcsar Zsolt , Lewandowski Sebastian , Piehl Fredrik , Granberg Tobias , Ineichen Benjamin Victor 
Published: May 2023

Background and objectivesAnimal models for motor neuron diseases (MND) such as amyotrophic lateral sclerosis (ALS) are commonly used in preclinical research. However, it is insufficiently understood how much findings from these model systems can be translated to humans. Thus, we aimed at systematically assessing the translational value of MND animal models to probe their external validity with regards to magnetic resonance imaging (MRI) features.MethodsIn a comprehensive literature search in PubMed and Embase, we retrieved 201 unique publications of which 34 were deemed eligible for qualitative synthesis including risk of bias assessment.ResultsALS animal models can indeed present with human ALS neuroimaging features: Similar to the human paradigm, (regional) brain and spinal cord atrophy as well as signal changes in motor systems are commonly observed in ALS animal models. Blood-brain barrier breakdown seems to be more specific to ALS models, at least in the imaging domain. It is noteworthy that the G93A-SOD1 model, mimicking a rare clinical genotype, was the most frequently used ALS proxy.ConclusionsOur systematic review provides high-grade evidence that preclinical ALS models indeed show imaging features highly reminiscent of human ALS assigning them a high external validity in this domain. This opposes the high attrition of drugs during bench-to-bedside translation and thus raises concerns that phenotypic reproducibility does not necessarily render an animal model appropriate for drug development. These findings emphasize a careful application of these model systems for ALS therapy development thereby benefiting refinement of animal experiments.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022373146.
Aspecte ale discursului contemporan din spaţiul social românesc
Authors: SOARE Ovidiu 
Published: May 2023

I sought to sketch a certain perspective of the discourse and, thus of the mentalities that troubled and have been troubling our society for the past half-century; our society is divided into two periods, one, a communist period, focused on a "utopian and bright" future, supported by an intense social control, and the other where we are today, where rumours and uncertainty are the order of the day. We hope that all these quests of our society, which has been in an endemic transition for several hundredyears, will eventually lead to that much-desired stability and credibility, present in any normal society.
Parâmetros produtivos e comportamentais de cabritos alimentados com enzimas exógenas na dieta
Authors: Freitas Ana Beatriz  Inácio de , Vilaça Lucas Eduardo Gonçalves , Siqueira Marco Túlio  Santos , Oliveira Karla Alves , Oliveira Marcela Rodrigues de , Macedo Júnior Gilberto de Lima , Santana Afranio Giroldo de 
Published: May 2023

O uso de enzimas exógenas é uma biotecnologia utilizada para otimizar a produção de ruminantes, através da melhora da digestibilidade e degradabilidade ruminal da fibra, do amido e da proteína presentes nos mais diversos alimentos. Objetivou-se avaliar o efeito de enzimas exógenas fornecidas como aditivo em ração para caprinos sobre os parâmetros produtivos e comportamentais. Foram utilizados 21 cabritos mestiços ½ Anglo Nubiano x ½ Saanen, com idade média de 2 meses, pesando em média 16,77 kg. Estes animais foram alojados em baias coletivas, distribuídos em quatro tratamentos: Controle (sem nenhuma adição de enzima); Amaize® (enzima amilolítica); Allzyme® (mix de enzimas) e Fibrozyme® (enzima fibrolíticas). Foram avaliados o consumo de matéria seca (CMS), desempenho e comportamento ingestivo. O delineamento utilizado foi inteiramente casualizado com medidas repetidas ao tempo. As médias dos tratamentos foram avaliadas pelo teste SNK ao nível de significância de 5% e os períodos por análise de regressão dos efeitos lineares e quadráticos à 5% de significância. A variável escore de condição corporal (ECC) foi avaliada por estatística não paramétrica. Os animais apresentaram aumento exponencial do CMS ao longo do período. Houve efeito linear negativo no período para as variáveis ingestão (ING) e mastigação (MAST). Houve efeito linear positivo no período para a variável OCIO. Não houve diferença entre tratamentos para ganho médio diário (GMD) e ganho de peso total (GPT). As variáveis altura de anterior (AA), comprimento corporal (CC), circunferência de barril (CB), circunferência torácica (CT) e peso corporal (PC) apresentaram efeito quadrático ao longo do período de avaliação. Altura de posterior (AP) apresentou efeito linear positivo para período. ECC apresentou diferença estatística entre os períodos sendo d45, d60, d75 e d90 estatisticamente semelhantes a d30 e superiores aos períodos d0 e d15. Houve interação entre tratamentos e período de avaliação para largura de peito (LP), com o tratamento Controle apresentando resposta linear positiva e os tratamentos Amaize®, Allzyme® e Fibrozyme® apresentando resposta quadrática. A utilização de enzimas exógenas não afeta os parâmetros produtivos e comportamentais de caprinos em desenvolvimento.
Pengaruh Gel Ekstrak Daun Salam terhadap Angiogenesis pada Proses Penyembuhan Ulser Traumatik Oral
Authors: Kusuma Ira A. , Istiadi Hermawan , Firawan Kurnia N. P. , Aulia Shofi 
Published: May 2023

Currently, the healing process of traumatic oral ulcers is assisted by chemical drugs that aim to stimulate the wound healing process; one of which is angiogenesis. However, long-term use can cause side effects. Therfore, alternative materials with minimal side effects are needed inter alia bay leaf. This study aimed to determine the effect of bay leaf gel extract on increasing angiogenesis in the healing process of traumatic oral ulcers. Samples were Wistar rats according to the inclusion criteria, divided into three groups, namely K group, the control group (treated with carbomer gel); P1, treated with 5% bay leaf extract gel; and P1, treated with 10% bay leaf extract gel. Data were analyzed with the Kolmogorov Smirnov normality test, the Levene's test for homogeneity, and were continued with the parametric One-Way Anova and Post Hoc Least Significant Difference tests. The results indicated that there was an effect of bay leaf gel extract on increasing angiogenesis process in the healing process of traumatic ulcers. Treatment with 10% bay leaf extract gel (P2 group) had a significant effect (p<0.05) in increasing angiogenesis compared to the K group and the P1 group. In conclusion, bay leaf extract gel has an effect on increasing angiogenesis in the healing process of traumatic ulcers.
Keywords: traumatic ulcer; bay leaf extract gel; angiogenesis

Abstrak: Saat ini, proses penyembuhan ulser traumatik dibantu dengan pemberian obat-obatan kimia yang bertujuan untuk merangsang proses penyembuhan luka, salah satunya angiogenesis. Namun penggunaan dalam jangka panjang dapat menimbulkan efek samping. Untuk itu diperlukan bahan alternatif dengan efek samping minimal antara lain daun salam. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak gel daun salam terhadap peningkatan angiogenesis pada proses penyembuhan ulser traumatik. Sampel penelitian ialah tikus wistar sesuai kriteria inklusi dan dibagi menjadi tiga kelompok yaitu kelompok K, kelompok kontrol (perlakuan dengan gel carbomer); P1, kelompok perlakuan dengan gel ekstrak daun salam 5%; dan P2, dengan perlakuan gel ekstrak daun salam 10% . Analisis data menggunakan uji normalitas Kolmogorov-Smirnov, uji homogenitas Levene, dan dilanjutkan dengan uji parametrik One-Way Anova dan Post Hoc Least Significant Difference. Hasil penelitian ini menunjukkan terdapat pengaruh pemberian ekstrak gel daun salam terhadap peningkatan proses angiogenesis pada proses penyembuhan ulser traumatik. Gel ekstrak daun salam 10% memiliki pengaruh yang bermakna (p<0,05) dalam peningkatan angiogenesis dibandingkan kelompok kontrol (K) dan perlakuan gel ekstrak daun salam 5%. (P1) Simpulan penelitian ini ialah gel ekstrak daun salam berpengaruh dalam meningkatkan angiogenesis dalam proses penyembuhan ulser traumatik.
Kata kunci: ulser traumatik; gel ekstrak daun salam; angiogenesis
أثر استراتيجية الاستقصاء في تدريس التخطيط والألوان
Authors: ليلى شويل حسين  
Published: May 2023

تعد العملية التعليمية نشاطا تو اصليا تهدف الى اثارة دافعية المتعلم وتسهيل التعلم» اذتتضمن مجموعة من النشاطات والقرارات التي يتخذها) المدرس - المتعلم (في الموقفالتعليمي من خلال الاهتمام بطرائق التدريس وتقنياتها وتنظيم اشكال التعلم في الموقفالتعليمي الذي يتفاعل من خلاله المتعلمون لغرض تحقيق اهداف تعليمية محددة. بالتأكيد يتمذلك من خلال تصميم مقصود للبيئة التعليمية وهندستها) تنظيم الخبرات التعليمية (بطريقةمعينة بحيث تؤدي الى تحقيق تعليم مقصود لدى المتعلمين وباشراف التدريسي. لذلك لابد من توفير الشروط المادية والنفسية التي تساعد المتعلم على التفاعل النشطمع مكونات البيئة التعليمية المصممة للموقف التعليمي من اجل اكسابه الخبرات التعليميةوالمعلومات المعرفية والمهارت الفنية والاتجاهات والقيم التي يحتاجها بما يتناسب مع قدراتهواستعداداته بطرائق تعليمية واساليب تسهم في مدركاته الحسية للمعلومات التي يكتسبها فيالموقف التعليمي ومن ثم تساعده على كيفية معالجة هذه المعلومات وعملية استرجاعهاوتوظيفها في المواقف التعليمية الجديدة. بناء على ما نقدم ارتأت) الباحثة (التأسيس لمشكلة بحثها من خلال توظيف)استراتيجية الاستقصاء (في بيئة تعليمية لتنظيم المعلومات وطرائق اكتسابها من قبل المتعلموتخزينها في ذاكرته واساليب استرجاعها على وفق متطلبات الموقف التعليمي من خلالقدراته واستعداداته لتقبل الخبرات التعليمية) المعرفية والمهارية (المتعلقة بالرسم وبياناثرها في اكتساب المهارات الفنية وتعزيز دوره الايجابي في الكيفية التي يوظفها في انجازعمله الفني كالمنظور والطبيعة الصامتة والانشاء التصويري والمشروع الفني .....و غيرها.هدف البحث الحالي هو الكشف عن) استراتيجية الاستقصاء واثرها في تدريس الفنون(لذلك وضعت الباحثة هدفين فرعيين لتحقيقه تمثلا
Synthesis of new N-Substituted -3- chloro -2- azetidinones for 2, 4-Diamino-6-phenyl-1,3,5-triazine
Authors: Tamador A. Mahmood  
Published: May 2023

The current study involved synthesis of several new N-Substituted -
3- chloro -2- azetidinones for 2,4-Diamino-6-phenyl-1,3,5-triazine by two
steps. The first step includes preparation of Schiff bases (Al-A6) by
condensation of 2,4-Diamino-6-pheny]-1,3,5-triazine with many substituted
aldehydes, then the second step includes preparation new six azetidinone
compounds (B1-B6) by reaction of chloro acetyl chloride with the
prepared Schiff bases in first step. The prepared compounds were
characterized by physical properties, FT-IR, UV and some of them by 'H-
NMR, "C-NMR spectroscopy were recorded.
Synthesis and Characterization of some biologically active transition metal complexes for a ligand derived from dimedone with mixed ligands.
Authors: Ahmed T. Numan  
Published: May 2023

The aim of the work is synthesis and characterization of bidentate ligand
[3-(3-acetylphenylamino)-5,5-dimethylcyclohex-3-enone][HL], from the
reaction of dimedone with 3-amino acetophenone to produce the ligand
[HL], the reaction was carried out in dry benzene as a solvent under reflux.
The prepared ligand [HL] was characterized by FT-IR, UV-Vis
spectroscopy, 'H, 8C-NMR spectra, Mass spectra, (C.H.N) and melting
point. The mixed ligand complexes were prepared from ligand [HL] was
used as a primary ligand while 8-hydroxy quinoline [HQ] was used as a
secondary ligand with metal ion M(IT).Where M(IT) = (Mn ,Co ,Ni ,Cu ,Zn
,Cd and Pd) at reflux ,using ethanol as a solvent, KOH as a base.
Complexes of the composition [M(L)(Q)] with (1:1:1) molar ratio were
prepared . All the complexes were characterized by spectroscopic methods
(FT-IR, UV-Vis spectroscopy) along with elemental analysis (A.A),
chloride content and melting point measurements were carried out, together
with conductivity and magnetic susceptibility. These measurements showed
tetrahedral geometry around (Mn", Col, Ni, Cu", Zn! and Cd") ions and
square planner around (Pd") ion. The biological activity of the ligands
[HL],[HQ] ] and complexes (MLQ): were studied using inhibition method.
Image Classification using Different Machine Learning Techniques
Authors: Alaba Simegnew 
Published: May 2023

<p>Artificial Neural Networks and Convolutional Neural Networks have become common tools for classification and object detection, owing to their ability to learn features without prior knowledge. During training, these networks learn the parameters, weights, and biases. This paper proposes a simple Neural Network and Convolutional Neural Network (CNN) for a classification task. Furthermore, the Bayesian neural network work is reproduced as a baseline for comparing my proposed networks. All experiments were conducted using the MNIST dataset.</p>
<p>While the simple neural networks and the convolutional networks adjust their parameters based on the cost function during training, the Bayesian convolutional neural network updates its parameters based on the backdrop that drives a variational approximation to the true posterior. Hyperparameters such as optimizer, learning rate, regularizers, dropout, epochs, etc., were varied to train the two proposed networks. The proposed networks achieved better classification accuracy, approximately 99\%, than the previously implemented Bayesian convolutional neural network. However, it is difficult to predict the certainty of the predictions made by my proposed networks, unlike Bayesian learning, which makes it easy to do so. \href{https://github.com/Simeon340703/Classification_Networks}{You can find the code for this work at}.</p>
Life on land :An accurate centralized system for ensuring the safety and wellbeing of domestic and wild animals
Authors: heshan Adithya , Wickramathilake Shamilka , Gunathilake Dulmi , Herath Hiruni , Samarasekara Piyumika , de silva Dilshan 
Published: May 2023

<p>Described above has the potential to make a significant contribution to the conservation of endangered wildlife and the responsible management of domestic animals. </p>