bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Massage on Neuro-Vascular Regulation and Apoptosis in Rabbits with Cervical Spondylosis of the Vertebral Artery Type
Authors: Wang Chao , Xu Hui , Xiong Yingzong , Su Yi , Li Yingchun , Zhu Junchen 
Published: February 2023

AbstractObjective To explore the therapeutic mechanisms of massage for cervical spondylosis of vertebral artery type (CSA) from the effects of sympathetic neurotransmitter changes on vertebral artery blood flow and apoptosis. Methods Forty rabbits were randomly divided into a normal group, model group, electroacupuncture (EA) group, and massage group, with 10 rabbits in each group. The CSA rabbit model was established by neck injection of sclerosing agent in all groups except the normal group. In the EA group, the left “Fengchi” (GB 20) and the 3rd-5th cervical vertebrae (C3-5) “Jiaji” (EX-B2) were selected for EA treatment. In the massage group, pushing manipulation with one finger was performed at 0.5 cm to the left side of the C3-5 spinous process and the tip of the transverse process. The vertebral artery blood flow was detected by laser Doppler. The levels of serum neuropeptide Y (NPY) and norepinephrine (NE) were determined by ELISA. The pathological morphological changes of vertebral arteries were observed by HE staining. The apoptosis of vertebral arteries and cerebella were detected by Tunel assay. The protein expressions of CHOP, Bcl-2, and Bax in vertebral arteries and cerebella were detected by Western blot. Results Vertebral artery blood flow was significantly decreased in all rabbits after modeling. Massage increased vertebral artery blood flow, decreased serum levels of NPY and NE which secreted by sympathetic nerves, improved vertebral artery lumen narrowing, intimal thinning, and mesenteric smooth muscle cell alignment. Moreover, these effects were superior to that in the EA group. In addition, the massage group significantly reduced the apoptotic index, decreased the CHOP and Bcl-2 associated X protein (Bax) protein expressions, and increased the B-cell lymphoma-2 (Bcl-2) protein expression in vertebral arteries and cerebella relative to the model group. Conclusion The treatment of CSA has a neuro-vascular regulatory mechanism. Massage can decrease the release of sympathetic neurotransmitters that constrict blood vessels and mitigate apoptosis induced by excessive endoplasmic reticulum stress (ERS) due to sympathetic excitation, so as to improve vertebral artery blood flow and serve as a treatment for CSA.
Optimization of PAS reaction and similar Schiff`s based methods for glycogen demonstration in liver tissue.
Authors: Abdellah Marwah Abdelrahman , Abdallah Maisa Aldai , Abdalrheem Abeer Babiker , Gubara Alobeid Mohammed , Batran Samah Abd-Elrahim , Zakout Yosef Mohamed-Azzam , Zakout Yosef Mohamed-Azzam 
Published: February 2023

Abstract
Purpose
Demonstration of glycogen in tissue has valuable diagnostic significance in several lesions, including certain tumors. Histochemical staining of glycogen with Schiff's dependent methods is affected by the type of fixative, the temperature of fixation, and oxidizing agents. This study aimed to evaluate different fixatives, temperatures of fixation, and oxidizing agents with variable durations of treatment to be used with Schiff's reagent for glycogen demonstration.
Methods
Archived paraffin blocks prepared from one rabbit's liver were used and 340 paraffin sections were stained with different oxidizers-Schiff methods.
Results
For tissues fixed at 4°C: 10% NBF, 80% alcohol, and Bouins's solution provided good staining results with PAS reaction. For tissues fixed at RT: both 10% NBF and 80% alcohol provided good staining results with PAS reaction. The other oxidizing agents provided poor results with all fixatives and temperature of fixation, with two exceptions of satisfactory staining results for 5% chromic acid for 10 minutes at both room temperature (RT) and 60°C.
Conclusion
Both 10% NBF and 80% alcohol seem to be the fixatives of choice for glycogen when the PAS reaction is used. However, Bouin's solution could provide good results at 4° C.
Possible thalassemia intermedia in a child (16th-18th centuries) from the westernmost part of Europe: potential association with malaria and past Islamic migration
Authors: Calleja Álvaro M. Monge , Lourenço Marina , Macedo Marta , Gaspar Rosa Ramos , Ribeiro M. Letícia , Santos Ana Luísa 
Published: February 2023

Abstract

This study aims to describe a non-adult individual with bone features suggestive of β-Thalassemia, diseases frequent in malaria-endemic regions today and in the past. The skeleton of a 5.5-6.5-year-old child exhumed from a 16th -18th centuries CE necropolis in Almeirim (Portugal) was examined macroscopically, with scanning electron microscope, and by conventional radiology and computed tomography. This individual shows frontoparietal diploic hyperplasia with a slight hair-on-end radiographic appearance and an exuberant serpiginous pattern. The orbital roofs have a plaque-like formation and facial bones display new bone proliferation and porosity. The teeth show caries, calculus deposition, anomalies on the four deciduous canine roots, and linear enamel hypoplasia on the first permanent right upper central incisor. The postcranial skeleton presents developmental delay, osteopenic trabecular appearances, cribra humeralis and cribra femoralis, the latter associated with malaria. A second non-adult individual (2.5–3.5 years old) had similar lesions in the cranium, raising the question if they were siblings. The lesions are consistent with β-Thalassemia intermedia, a homozygous or compound heterozygous hemoglobinopathy found in malaria endemic regions, such as Almeirim, due to the protective advantage conferred by β-Thalassemia carriers. Thalassemia presents a wide spectrum of lesions common in other hemolytic anemias, which difficult their diagnosis. Hopefully, biomolecular techniques will assist the diagnosis in skeletonized individuals. To the authors’ knowledge, this is the first possible case of thalassemia in the westernmost part of Europe, in a region currently with high prevalence of hemoglobinopathies, attributed to the past Islamic and sub-Saharan presence, and in an area historically affected by malaria.
Performance Emission and Combustion Characteristics of Ethanol Hydrogen Blends at MBT Spark Timing on Multi-cylinder SI Engine
Authors: Nitnaware Pravin , Suryawanshi Jiwak 
Published: February 2023

Abstract
Alternative fuels are the need of the current situation as conventional fuels are depleting very quickly and causing increase in amounts of pollution. Hydrogen as a clean fuel with Higher Calorific Value plays important role in increasing combustion characteristics. When compared with the performance of ethanol as a fuel, ethanol-hydrogen blends have demonstrated a 5% increase in power production, 15% reduction in hydrocarbon emissions, and 12% reduction in carbon dioxide emissions. All tests are conducted at speed of 2500, 3000, 3500, 4000, and 4500 rpm with the Wide-Open-Throttle (WOT) condition. CO & HC emissions are reduced using ethanol, whereas hydrogen addition enhanced the decreased power output, higher brake-specific fuel consumption and in cylinder pressure.
Exploring the Integration of Machine Learning Models in Programming Languages on GitHub: Impact on Compatibility to Address Them
Authors: slama faten , Ismail Imen , latrach lassaad 
Published: February 2023

Abstract
The complex field of accounting and how information technologies have impacted the way it's managed. It explains how many accounting tasks, such as data entry, billing, and expense management, can be automated using programming languages, and how visualization tools can help present the data clearly. The use of GitHub projects for accounting purposes can lead to improved efficiency and better financial decision-making. However, compatibility issues may arise on GitHub due to differences in programming languages, frameworks, or operating systems. These issues can be resolved by updating code or making changes, and by consulting the issues page, other repositories, or the language/library documentation. Other programming difficulties, such as performance problems or conflicts with other libraries, can also occur. A file extension approach (EF) for defining GitHub project domains in programming languages was presented, which involved sorting file extensions, computing percentage of each extension, and determining the dominant language. The study also investigated the connection between this EF approach and compatibility issues. The technique was used to recover over 200 deposits from GitHub, though the dataset content needs to be organized first.In this paper, we extend our previous work and describe in detail new algorithms and strategies to improve the efficiency and effectiveness of compatibility testing. To validate our approach, we have performed experiments and simulations on two widely-used middle libraries from the field of high-performance computing. For this paper, we restrict the compatibility testing to the build process (i.e. compilation and deployment) of a component with other components on which it depends, but we will extend the work to functional and performance testing in future work.
Effect of Music Therapy Treatment on Hospitalized Onco-Hematological Patients’ Anxiety, Sadness, Physical Discomfort, Mood and Quality of Life
Authors: Martí Patricia , Fontanals Irene , Funtané Joel , Canaletas Cristina , Sierra Jorge , Rodés Mariona , Mercadal-Brotons Melissa , González Iria , Novelli Silvana 
Published: February 2023

Abstract
Physical and psychological distress may be present when facing an onco-hematological diagnosis and undergoing complex therapies such as intensive chemotherapy, stem cell transplantation, and immunotherapy. Studies show the need for incorporating different therapeutic modalities to respond to patients’ physical and psychosocial needs. Aims: The purpose of this study is to evaluate the effectiveness of a music therapy treatment on mood, anxiety, depression, and physical discomfort of onco-hematological inpatient/hospitalized patients. Materials and Methods: Twenty-eight patients participated in a music therapy program. Treatment consisted of individual weekly music therapy sessions. Participants completed the following evaluation instruments before and after the intervention (pre/post-treatment): HADS (Hospital Anxiety and Depression Scale), POMS-A (Profile of Mood States - Short Form A-Version), Quality of Life EORTC QLQ-C30 (European Organization for Research and Treatment of Cancer-Quality of Life Core Questionnaire-30). A three-item Numerical Rating Scale (NRS) for Anxiety, Sadness, and Physical Discomfort was administered at the beginning and end of each session (pre/post-session). Results: The NRS results showed differences (p<0.05) between scores pre- and post-music therapy sessions in the three spheres: Anxiety, Sadness, and Physical Discomfort. Quality of life (QoL) is affected in almost all items, and patients might be anxious at a non-clinical level, but they do suffer from depressive moods as a clinical case.
Conclusion: Music therapy can positively change emotional distress and improve the mood of hematological patients. Despite the difficulties and limitations of this study, this preliminary report contributes to a greater understanding of the potential benefits of music therapy in hospitalized onco-hematological patients.
The quantification and tracing of harvest leakage in North Europe
Authors: Hu Junhui , Jåstad Eirik Ogner , Bolkesjø Torjus Folsland , Rørstad Per Kristian 
Published: February 2023

Abstract
The policy and measures that alter forest harvest level can be greatly offset by the presence of harvest leakage. Our study has quantified the leakage rates in four Nordic countries when a range of harvest shocks are introduced. A partial equilibrium forest sector model named the Nordic Forest Sector Model (NFSM) with 31 regions is applied for the purpose of the study. The roundwood leakage rates range from 58% to 91% in Norway, 73% to 91% in Sweden, 75% to 107% in Finland, and 59% to 106% in Denmark within the tested range. The leakage rates for sawlogs can be over 100% when the leakage of both sawnwood production and sawlogs happens the same time, and they can also be small if synergistic effect is present. The extra-Nordic leakage dominates the harvest leakage if harvest changes in one of the studied Nordics countries, and the leakage of the sawlogs harvest is a combined result of leakage of the raw materials (sawlogs) and the leakage of the production (sawnwood), while the leakage of pulpwood harvest is solely a result of leakage of the raw materials (pulpwood). The substitution of pulpwood by harvest residues and black liquor is significant in bioheat sector when harvest of pulpwood change. Therefore, we highly recommend that extra caution should be taken if a climate action may affect the level of the forest harvesting, and the harvest leakage effect on domestic industries, international trading should be awarded in open markets.
Assessment of Treatment Response to Dendritic Cell Vaccine in Patients with Glioblastoma using a Multiparametric MRI-Based Prediction Model
Authors: de Godoy Laiz Laura , Chawla Sanjeev , Brem Steven , Wang Sumei , O’Rourke Donald M , Nasrallah MacLean P. , Desai Arati , Loevner Laurie A. , Liau Linda M. , Mohan Suyash 
Published: February 2023

Abstract
Purpose
Autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) is a promising treatment modality for glioblastomas. The purpose of this study was to investigate the potential utility of multiparametric MRI-based prediction model in evaluating treatment response in glioblastoma patients treated with DCVax-L.
Methods
Seventeen glioblastoma patients treated with standard-of-care therapy + DCVax-L were included. When tumor progression was suspected and repeat surgery was being contemplated, we sought to ascertain the number of cases correctly classified as true progression (TP) + mixed response or pseudoprogression (PsP) from multiparametric MRI-based prediction model using histopathology/mRANO criteria as ground truth. Multiparametric MRI model consisted of predictive probabilities (PP) of tumor progression computed from diffusion and perfusion MRI-derived parameters. A comparison of overall survival (OS) was performed between patients treated with standard-of-care therapy + DCVax-L and standard-of-care therapy alone (external controls). Additionally, Kaplan-Meier analyses were performed to compare OS between two groups of patients using PsP, Ki-67, and MGMT methylation status as stratification variables.
Results
Multiparametric MRI model correctly predicted TP + mixed response in 72.7% of cases (8/11) and PsP in 83.3% (5/6) with an overall concordance rate of 76.5% with final diagnosis as determined by histopathology/mRANO criteria. There was a significant concordant correlation coefficient between PP values and histopathology/mRANO criteria (r = 0.54; p = 0.026). DCVax-L-treated patients had significantly prolonged OS than those treated with standard-of-care therapy (22.38 ± 12.8 vs. 13.8 ± 9.5months, p = 0.040). Additionally, glioblastomas with PsP, MGMT methylation status, and Ki-67 values below median had longer OS than their counterparts.
Conclusion
Multiparametric MRI-based prediction model can assess treatment response to DCVax-L in patients with glioblastoma.
The Downregulation of miR-509-3p Expression by Collagen Type XI Alpha 1-Regulated Hypermethylation Facilitates Cancer Progression and Chemoresistance via the DNA Methyltransferase 1/Small Ubiquitin-like Modifier-3 Axis in Ovarian Cancer Cells
Authors: Wu Yi-Hui , Huang Yu-Fang , Wu Pei-Ying , Chang Tzu-Hao , Huang Soon-Cen , Chou Cheng-Yang 
Published: February 2023

Abstract
Background
MicroRNAs are a group of small non-coding RNAs that are involved in development and diseases such as cancer. Previously, we demonstrated that miR-335 is crucial for preventing collagen type XI alpha 1 (COL11A1)-mediated epithelial ovarian cancer (EOC) progression and chemoresistance. Here, we examined the role of miR-509-3p in EOC.
Methods
The patients with EOC who underwent primary cytoreductive surgery and postoperative platinum-based chemotherapy were recruited. Their clinic-pathologic characteristics were collected, and disease-related survivals were determined. The COL11A1 and miR-509-3p mRNA expression levels of 161 ovarian tumors were determined by real-time reverse transcription-polymerase chain reaction. Additionally, miR-509-3p hypermethylation was evaluated by sequencing in these tumors. The A2780CP70 and OVCAR-8 cells transfected with miR-509-3p mimic, while the A2780 and OVCAR-3 cells transfected with miR-509-3p inhibitor. The A2780CP70 cells transfected with a small interference RNA of COL11A1, and the A2780 cells transfected with a COL11A1 expression plasmid. Site-directed mutagenesis, luciferase, and chromatin immunoprecipitation assays were performed in this study.
Results
Low miR-509-3p levels were correlated with disease progression, a poor survival, and high COL11A1 expression levels. In vivo studies reinforced these findings and indicated that the occurrence of invasive EOC cell phenotypes and resistance to cisplatin are decreased by miR-509-3p. The miR-509-3p promoter region (p278) is important for miR-509-3p transcription regulation via methylation. The miR-509-3p hypermethylation frequency was significantly higher in EOC tumors with a low miR-509-3p expression than in those with a high miR-509-3p expression. The patients with miR-509-3p hypermethylation had a significantly shorter overall survival (OS) than those without miR-509-3p hypermethylation. Mechanistic studies further indicated that miR-509-3p transcription was downregulated by COL11A1 through a DNA methyltransferase 1 (DNMT1) phosphorylation and stability increase. Moreover, miR-509-3p targets small ubiquitin-like modifier (SUMO)-3 to regulate EOC cell growth, invasiveness, and chemosensitivity.
Conclusion
The miR-509-3p/DNMT1/SUMO-3 axis may be an ovarian cancer treatment target.
Reconstruction of the shape and surface impedance from Cauchy data for the Helmholtz equation
Authors: Liu Ji-Chuan 
Published: February 2023

Abstract
In this paper, we are concerned with the coefficients identification for the Helmholtz equation. This problem which consists of determining an unknown inner boundary of an annular domain and surface heat transfer coefficient from boundary Cauchy data. We propose two reconstruction algorithms to simultaneously recover the shape and the surface impedance of the obstacle within a body. This problem is ill-posed, thus we apply regularization techniques in order to improve the corresponding approximation. Numerical experiments are presented for the reconstruction algorithms, which show that both the shape and the surface impedance can be reconstructed accurately.
AMS Mathematics Subject Classification 2010: 65N20,65N21.
Microgrid's regulation using a multiport SST
Authors: Ramirez Juan M , Arizaga-Ayala Francisco J , Alcala Janeth A. 
Published: February 2023

Abstract
A solid-state transformer controlled by a virtual synchronous generator is presented as an element capable of increasing the flexibility of electrical power distribution in a modern grid. With the advent of microgrids, the choice of strategies and devices capable of giving them flexibility has been of paramount importance. Emphasis has been shown on the transformer characteristics to regulate the frequency and voltage at its output terminals. This is very suitable for driving a wind turbine. Results are presented that demonstrate the versatility of such features working together.
Changes in Deiodinase Activity and Analysis of Related Influencing Factors in Growth Hormone-Secreting Pituitary Adenoma
Authors: Mo Caiyan , Wang Yao , Tong Tao , Chen Han , Guo Ying , Zhong Liyong 
Published: February 2023

Abstract
Purpose
Free triiodothyronine (FT3)/ free thyroxine (FT4) ratio is often considered as an indicator of deiodinase activity in the context of multiple diseases. We aimed to investigate the changes in deiodinase activity in growth hormone-secreting pituitary adenoma (GHPA) patients at high levels of growth hormone (GH) / insulin-like growth factor-1 (IGF-1) and analyze related influencing factors.
Methods
A retrospective cross-sectional study was conducted to collect demographic and clinical data of 128 GHPA patients with normal thyroid function from the Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University during 2015-2022. Pearson correlation test and linear regression analysis were used to analyze the relationship between FT3/ FT4 ratio and GH, IGF-1, insulin-like growth factor binding protein-3 (IGFBP-3), homeostasis model assessment of insulin resistance(HOMA-IR), body mass index (BMI) and age.
Results
1. FT3/FT4 ratio was positively correlated with GH and IGFBP-3, but had no significant correlation with IGF-1. 2. FT3/FT4 ratio was positively correlated with BMI and negatively correlated with age. 3. FT3/FT4 ratio was positively correlated with fasting insulin (FINS) and HOMA-IR, but had no significant correlation with fasting C-peptide (FCP). 4. In multivariate analysis, FT3/FT4 ratio was independently associated with age and BMI.
Conclusion
In GHPA patients, high circulating levels of GH/IGF-1/IGFBP-3 system, high insulin level and elevated BMI may increase the activity of deiodinase, leading to increased peripheral T3 level, which may be a compensation mechanism of the body. Besides, deiodinase activity decreases with age, suggesting that elderly GHPA patients should be alerted to the risk of hypothyroidism.
Numerical analysis for thermal performance of magnetized radiative nanofluid with variable density
Authors: Khan Aamir Abbas 
Published: February 2023

Abstract
The majority of study has focused on fluid surfaces with constant surface densities and low ambient temperature differentials. Due to the greater temperature differential with radiation, the density is believed to be an exponential function of temperature. The magnetohydrodynamics (MHD) acts like a coating material to protect technological devices from excessive heating. The main goal of this technique is to prevent excessive heating in high temperature systems by utilising the effects of changing density, MHD, and radiation on the heat and mass properties of nanofluid across stretched sheets. This is the first instance of a density issue with a nanofluid across a stretching surface. For a smooth algorithm and integration, the coupled partial differential equations (PDEs) of the current nanofluid mechanism are transformed into coupled nonlinear ODEs with defined stream functions and similarity variables. By using the Keller Box technique, the modified ODEs are again translated in a comparable format for numerical results. The MATLAB program is used to derive the numerical results, which are then presented in graphs and tabular form. For this phenomenon, the slopes of the velocity, temperature, and concentration profiles have been plotted for various parameters. As n increases, two forces will act on the nanofluid, the first of which causes the velocity to increase due to an increase in buoyancy forces and the second of which causes the velocity to decrease due to a decrease in temperature.