bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PENGGUNAAN MEDIA PEMBELAJARAN BERBASIS CANVA TERHADAP HASIL BELAJAR PKN SISWA KELAS 3 SD NEGERI 2 KAYU AGUNG
Authors: Muliani Safitri Tri , Adrianus Dedy  , Destiniar  
Published: August 2023

This study aims to determine the effect of using Canva-based learning media on PKN learning outcomes for class III students at SD Negeri 2 Kayu Agung. The research method used in this study was a Quasi-Experimental Posttest with a sample of 55 people. The sample in this study was taken using a simple random sampling technique. The data collection technique used was a multiple choice test with 20 questions. Based on the results of the study it can be seen that the significance value of 0 = 0.006 is smaller than alpha (α) = 0.05; with a tcount value of 3.226 and a ttable value of 1.672. It turns out that tcount > ttable or 2.889 > 1.674. This means that there is the effectiveness of Canva-based learning media on the learning outcomes of Civics in class III SD Negeri 2 Kayu Agung.
Keywords: canva-based media, learning outcomes
Pengembangan media ular tangga menggunakan metode tanya jawab pada pembelajaran matematika materi perkalian
Authors: Ratnawati  , Asmara Dwi Novri , Nurjanah Nurjanah 
Published: August 2023

ABSTRACT
Nurjanah, 2023. "The development of snakes and ladders media using the question and answer method in learning math multiplication material in class II SDN 11 Sitiung, Dharmasraya Regency.
This research is motivated by a lack of understanding in learning math multiplication material. This study aims to develop media to make it easier for students to understand the material. This type of research and development uses Research and development (R&D) research. This snakes and ladders media development model uses the ADDIE (Analyze, Design, Develop, Implementation, and Evaluation) development model. The five stages are carried out through needs analysis, learner analysis, and material analysis. Then the validation of snakes and ladders media is validated by UNDHARI FKIP lecturers, the practicality is done by looking at the responses of educators and students, the effectiveness is seen from the results of the test questions provided.
The results of developing snakes and ladders media were declared very valid. Valid means that the media that is carefully made has been validated and is suitable for use and developed with an average of 94.27% with a very valid category, the results of practicality with an average of 91.06% are categorized as very practical. which means that the media is suitable for use because it has been assessed for practicality in terms of media and practicality of time. The results of the effectiveness of the completeness of the results of students with an average of 90% are categorized as very effective, the media is suitable for use because the quality, quantity, and time are very effective. Thus it can be concluded that the snakes and ladders media made are very valid, practical, and effective for educators to use in teaching and learning.

Keywords: Development, Math, Multiplication.
PENANAMAN SIKAP SOSIAL MELALUI PEMBELAJARAN IPS PADA SISWA KELAS IV SD NEGERI 17 TANJUNG BATU
Authors: Dama Rizka Zakillah  , Murjainah  , M. Taheri Akhbar  
Published: August 2023

This study aims to describe: the results of instilling social attitudes in fourth grade students of SD Negeri 17 Tanjung Batu through social studies learning. This research is a descriptive qualitative study of cultivating social attitudes in grade IV students of SD Negeri 17 Tanjung Batu through Social Studies learning which was collected through observation and interviews as well as documentation. The data analysis used is the Miles and Huberman Model which consists of data collection, data reduction, data display and conclusion drawing or verification. The results of the study showed that: the social attitudes of fourth grade students at SD Negeri 17 Tanjung Batu were instilled through social studies learning by instilling the values ​​of students' social attitudes with social studies learning strategies, the teacher's ability to give examples of good interaction attitudes to students both in the classroom as well as outside the classroom, associating social studies subject matter with the values ​​of social attitudes and by providing positive sentences that contain social attitude values ​​at the beginning of learning, using social studies learning IT media, and conducting evaluations related to social attitudes. The results of inculcating social attitudes of class IV students at SD Negeri 17 Tanjung Batu through social studies learning have been embedded in the Good category. The teacher seems to have succeeded in instilling the value of social attitudes in accordance with the indicators that the researcher has described, namely: discipline, vocational, and tolerance in fourth grade students at SD Negeri 17 Tanjung Batu.
PENGEMBANGAN MEDIA CERITA BERGAMBAR PADA MATERI DONGENG SISWA KELAS II SEKOLAH DASAR
Authors: Nurul Hidayani  , Liza Murniviyanti  
Published: August 2023

This research was conducted at SD Negeri 6 Muara Telang, Banyuasin district, to find out the Development of Pictorial Story Media on Fairy Tales for Grade II Elementary School Students in Grade II students. The problem in this research is that the media used is still not attractive and innovative. The purpose of this study was to describe the validity and practicality of the results of the development of Pictorial Story Media on Fairytale Material for Grade II Elementary School Students. This type of research includes development research. The method used is the development research method or called Research and Development, and uses the ADDIE development model. The results of the development of picture story media at SD Negeri 6 Muara Telang, Banyuasin district. Based on the results of the data analysis which was distributed to the three experts, the score of linguists was 95% in the very practical category, media experts 96% in the very practical category and material experts 100% in the very practical category, meaning that the media can be concluded that the validity of the results of developing picture story media in material Fairy Tales for class II Elementary School students are very valid, and based on the results of the questionnaire distributed to students, a score of 76% is obtained, it can be concluded that practical and practical value criteria based on table 6, it can be concluded that Picture Story media is practical for use by the teacher as one of the media in the teaching and learning process in dogeng material at II SD Negeri 6 Muara Telang.
PENGEMBANGAN MEDIA VIDEO ANIMASI PADA MUATAN IPS MENGGUNAKAN APLIKASI CAPCUT DI KELAS V SDN 01 KOTO BARU
Authors: Yulia Darniyanti  , Muhammad Subhan  , Yuliska Hoiriyanti  
Published: August 2023

Theresearch was motivated by several problems, including first, the difficulty of teachers developing animated learning video media, especially for social studies learning of Geography characteristic material in Indonesia, second, teachers find it difficult to develop media in schools, third, students are less interested in the learning process, especially social studies content because social studies learning contains many theories. One effort that can attract the attraction of students is done by developing animated video learning media that can support students to learn well. Therefore, the author is interested in developing animated video learning media using the CapCut application in elementary schools. With the aim that teachers and students have enough adequate learning media. The type of research is research and development (R&D). Research and Development is a process and research steps to develop existing products, as well as new products that can later be accounted for. Develop a product a learning video. Research and development (R&D) Research and Development (R&D) methods are used to produce a particular product and tested for effectiveness. The development model used is the development of ADDIE " This ADDIE model was chosen because one of the teaching material development designs that are often used inthe development of ADDIE has 5 parts that are interconnected with one another: Analysis Stage, Design (Planning), Development Stage (Development), tahap Implementation, tahap Evaluation. Halil from the research of validation of animated video media of geographical characteristics material in Indonesia in class V in the validation test by two expert validators. Language validation by 80.00% lecturers falls into the very valid category. Media validation by 93.33% lecturers falls into the very valid category. Material validation by lecturers is 90.00% included in the very valid category.
Inversion Sequences Avoiding a Triple of Patterns of 3 Letters
Authors: Callan David , Jelínek Vít , Mansour Toufik 
Published: August 2023

An inversion sequence of length $n$ is a sequence of integers $e=e_1\cdots e_n$ which satisfies for each $i\in[n]=\{1,2,\ldots,n\}$ the inequality $0\le e_i < i$. For a set of patterns $P$, we let $\mathbf{I}_n(P)$ denote the set of inversion sequences of length $n$ that avoid all the patterns from~$P$. We say that two sets of patterns $P$ and $Q$ are I-Wilf-equivalent if $|\mathbf{I}_n(P)|=|\mathbf{I}_n(Q)|$ for every~$n$. In this paper, we show that the number of I-Wilf-equivalence classes among triples of length-3 patterns is $137$, $138$ or~$139$. In particular, to show that this number is exactly $137$, it remains to prove $\{101,102,110\}\stackrel{\mathbf{I}}{\sim}\{021,100,101\}$ and $\{100,110,201\}\stackrel{\mathbf{I}}{\sim}\{100,120,210\}$.
INTEGRATED QUALITY MANAGEMENT TO CREATE A SCHOOL AS A CENTER OF EXCELLENCE AT JUNIOR HIGH SCHOOL IN BANDUNG CITY (Description Study at SMP Negeri 5 and SMP Negeri 3 Bandung)
Authors: Ridwan Nurpalah  , Sutaryat Trisnamansyah  , Hanafiah  , Ida Tejawiani  
Published: August 2023

Schools are providers of formal education and centers of excellence for human empowerment. Salis stated that Integrated Quality Management (MMT) is “a philosophy of continuous improvement methodology, which provides a set of practical tools for every educational institution in meeting the needs, wants, and expectations of customers, current and future”. In general, the purpose of this study is to describe and analyze the concept of developing quality schools as MMT-based centers of excellence with the development of excellent services. This study uses a qualitative approach and data sources through interviews, observations and documentation through the principal, vice principal, teachers, and students. The results of data analysis showed that the principal's leadership in implementing MMT in SMP Negeri 5 and SMP Negeri 3 Bandung was quite effective in accordance with school planning. This is marked by the principal's continuous efforts to make improvements and changes as a whole in achieving quality, so that schools are realized as a source of excellence. The general conclusion is that the principal has management capabilities that are implemented in schools as a place for comfortable, harmonious, fun and quality education, as well as being highly competitive and having effective management supported by superior human resources to produce superior human resources with target achievement. set.
Pesan Dakwah dalam Film Pendek “Makr”
Authors: Hidayah Nurul , Ni’amah Luthfi Ulfa 
Published: August 2023

Film telah ada sejak zaman kuno. Sejarah dunia film mengalami perkembangan yang cukup panjang dari waktu ke waktu. Dari mulai ditemukan perangkat kinetoskop sebelum abad ke-20, kemudian berkembang hingga 1937 di zaman retro mulai 1980-an. Pada pertengahan 1970-an, film atau orang Barat memperkenalkan mereka dengan 'bioskop' mulai dikemas melalui kaset video dan kemunculan simultan cakram laser atau dvd, yang masih ditemui di era saat ini. Semakin banyak, film berkembang luas. Dimulai dengan film teater, music, film, pembuatan karya komersial, film televisi (FTV) dan film layar lebar. Melalui pertunjukan sebuah film, publik dapat mempresentasikan makna dari film tersebut. Pada film yang akan diteliti oleh peneliti ini, akan disajikan dari perspektif ajudikasi. Film pendek 'Makr' merupakan film yang diadaptasi dari realitas kehidupan manusia yang mengutamakan kepentingan duniawi hingga melupakan segalanya, termasuk keyakinannya. Film ini diunggah oleh channel youtube 'ALTER' ketika ramai dibicarakan oleh publik media sosial di tengah pandemi lalu. Film ini mengajarkan kita sebagai banyak muslim untuk selalu berpegang teguh kepada Allah SWT dan segera menghindari penyebarannya. Topik analisis film ini menggunakan analisis Theologies Adjutant. Kemudian dari segi sumber data, dihasilkan dari perpustakaan sumber dan analisis adegan. Film ini juga dikaji menggunakan studi kualitatif deskriptif. Agar lebih luas dan detail. Peneliti menyela film 'Makr' dari perspektif ajudikasi melalui adegan dan makna yang terkandung di dalamnya. Sehingga dapat diteliti dan menghasilkan analisis yang bermanfaat.
El modelo constitucional ecuatoriano
Authors: Cevallos Ortega Francisco Javier , Mena Manzanillas Paulina Leticia 
Published: August 2023

El Ecuador a lo largo de su historia ha pasado por varios sistemas que han dado origen a varias constituciones; pasó por un sistema conservador, luego por un sistema liberal, posteriormente pasó por un sistema dictatorial que fue derrotado dando origen a un sistema democrático que estuvo acompañado desde el derrocamiento de varios presidentes, la crisis económica que dio paso a la migración masiva, que hizo cada vez más visible la desigualdad social y la excusión de varios grupos. En este entorno la Asamblea Constituyente aprobó el texto constitucional del Ecuador en septiembre de 2008; y, en su elaboración participaron activamente antes y durante el proceso constituyente una comunidad de académicos del derecho que enarbolaron y posesionaron la bandera de lo que se denominó neo constitucionalismo ecuatoriano (Celi, 2017). En la nueva Constitución dejó de existir los tres poderes basados en Montesquieu, para dar paso a cinco poderes que se interrelacionan entre sí de manera horizontal y no de manera vertical, es decir se da paso a la coordinación como la base de la igualdad desterrando la subordinación de poderes anterior.
Role of CD36 in central nervous system diseases
Authors: Feng Min , Zhou Qiang , Xie Huimin , Liu Chang , Zheng Mengru , Zhang Shuyu , Zhou Songlin , Zhao Jian 
Published: August 2023

Abstract
CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic diseases. CD36 was recently found to be widely expressed in various cell types in the nervous system, including endothelial cells, pericytes, astrocytes, and microglia. CD36 mediates a number of regulatory processes, such as endothelial dysfunction, oxidative stress, mitochondrial dysfunction, and inflammatory responses, which are involved in many central nervous system diseases, such as stroke, Alzheimer’s disease, Parkinson’s disease, and spinal cord injury. CD36 antagonists can suppress CD36 expression or prevent CD36 binding to its ligand, thereby achieving inhibition of CD36-mediated pathways or functions. Here, we reviewed the mechanisms of action of CD36 antagonists, such as Salvianolic acid B, tanshinone IIA, curcumin, sulfosuccinimidyl oleate, antioxidants, and small-molecule compounds. Moreover, we predicted the structures of binding sites between CD36 and antagonists. These sites can provide targets for more efficient and safer CD36 antagonists for the treatment of central nervous system diseases.
Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review
Authors: Han Bo , Liang Weishi , Hai Yong , Sun Duan , Ding Hongtao , Yang Yihan , Yin Peng 
Published: August 2023

Abstract
Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity. With the increased degree and duration of distraction, spinal cord injuries become more serious in terms of their neurophysiology, histology, and behavior. Very few studies have been published on the specific characteristics of distraction spinal cord injury. In this study, we systematically review 22 related studies involving animal models of distraction spinal cord injury, focusing particularly on the neurophysiological, histological, and behavioral characteristics of this disease. In addition, we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury. We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research, and provide reference guidelines for the clinical diagnosis and treatment of this disease.
Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer’s disease
Authors: Chang Jun , Li Yujiao , Shan Xiaoqian , Chen Xi , Yan Xuhe , Liu Jianwei , Zhao Lan 
Published: August 2023

Abstract
Recent studies have demonstrated that neuroplasticity, such as synaptic plasticity and neurogenesis, exists throughout the normal lifespan but declines with age and is significantly impaired in individuals with Alzheimer’s disease. Hence, promoting neuroplasticity may represent an effective strategy with which Alzheimer’s disease can be alleviated. Due to their significant ability to self-renew, differentiate, and migrate, neural stem cells play an essential role in reversing synaptic and neuronal damage, reducing the pathology of Alzheimer’s disease, including amyloid-β, tau protein, and neuroinflammation, and secreting neurotrophic factors and growth factors that are related to plasticity. These events can promote synaptic plasticity and neurogenesis to repair the microenvironment of the mammalian brain. Consequently, neural stem cells are considered to represent a potential regenerative therapy with which to improve Alzheimer’s disease and other neurodegenerative diseases. In this review, we discuss how neural stem cells regulate neuroplasticity and optimize their effects to enhance their potential for treating Alzheimer’s disease in the clinic.
Single-neuron neurodegeneration as a degenerative model for Parkinson’s disease
Authors: Huenchuguala Sandro , Segura-Aguilar Juan 
Published: August 2023

Abstract
The positive effect of levodopa in the treatment of Parkinson’s disease, although it is limited in time and has severe side effects, has encouraged the scientific community to look for new drugs that can stop the neurodegenerative process or even regenerate the neuromelanin-containing dopaminergic nigrostriatal neurons. Successful preclinical studies with coenzyme Q10, mitoquinone, isradipine, nilotinib, TCH346, neurturin, zonisamide, deferiprone, prasinezumab, and cinpanemab prompted clinical trials. However, these failed and after more than 50 years levodopa continues to be the key drug in the treatment of the disease, despite its severe side effects after 4–6 years of chronic treatment. The lack of translated successful results obtained in preclinical investigations based on the use of neurotoxins that do not exist in the human body as new drugs for Parkinson’s disease treatment is a big problem. In our opinion, the cause of these failures lies in the experimental animal models involving neurotoxins that do not exist in the human body, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine, that induce a very fast, massive and expansive neurodegenerative process, which contrasts with the extremely slow one of neuromelanin-containing dopaminergic neurons. The exceedingly slow progress of the neurodegenerative process of the nigrostriatal neurons in idiopathic Parkinson’s patients is due to (i) a degenerative model in which the neurotoxic effect of an endogenous neurotoxin affects a single neuron, (ii) a neurotoxic event that is not expansive and (iii) the fact that the neurotoxin that triggers the neurodegenerative process is produced inside the neuromelanin-containing dopaminergic neurons. The endogenous neurotoxin that fits this degenerative model involving one single neuron at a time is aminochrome, since it (i) is generated within neuromelanin-containing dopaminergic neurons, (ii) does not cause an expansive neurotoxic effect and (iii) triggers all the mechanisms involved in the neurodegenerative process of the nigrostriatal neurons in idiopathic Parkinson’s disease. In conclusion, based on the hypothesis that the neurodegenerative process of idiopathic Parkinson’s disease corresponds to a single-neuron neurodegeneration model, we must search for molecules that increase the expression of the neuroprotective enzymes DT-diaphorase and glutathione transferase M2-2. It has been observed that the activation of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 pathway is associated with the transcriptional activation of the DT-diaphorase and glutathione transferase genes.
Chitosan-based thermosensitive hydrogel with long-term release of murine nerve growth factor for neurotrophic keratopathy
Authors: Wu Jie , Huang Yulei , Yu Hanrui , Li Kaixiu , Zhang Shifeng , Qiao Guoqing , Liu Xiao , Duan Hongmei , Huang Yifei , So Kwok-Fai , Yang Zhaoyang , Li Xiaoguang , Wang Liqiang 
Published: August 2023

Abstract

JOURNAL/nrgr/04.03/01300535-202403000-00045/inline-graphic1/v/2023-09-27T141015Z/r/image-tiff

Neurotrophic keratopathy is a persistent defect of the corneal epithelium, with or without stromal ulceration, due to corneal nerve deficiency caused by a variety of etiologies. The treatment options for neurotrophic keratopathy are limited. In this study, an ophthalmic solution was constructed from a chitosan-based thermosensitive hydrogel with long-term release of murine nerve growth factor (CTH-mNGF). Its effectiveness was evaluated in corneal denervation (CD) mice and patients with neurotrophic keratopathy. In the preclinical setting, CTH-mNGF was assessed in a murine corneal denervation model. CTH-mNGF was transparent, thermosensitive, and ensured sustained release of mNGF for over 20 hours on the ocular surface, maintaining the local mNGF concentration around 1300 pg/mL in vivo. Corneal denervation mice treated with CTH-mNGF for 10 days showed a significant increase in corneal nerve area and total corneal nerve length compared with non-treated and CTH treated mice. A subsequent clinical trial of CTH-mNGF was conducted in patients with stage 2 or 3 neurotrophic keratopathy. Patients received topical CTH-mNGF twice daily for 8 weeks. Fluorescein sodium images, Schirmer’s test, intraocular pressure, Cochet-Bonnet corneal perception test, and best corrected visual acuity were evaluated. In total, six patients (total of seven eyes) diagnosed with neurotrophic keratopathy were enrolled. After 8 weeks of CTH-mNGF treatment, all participants showed a decreased area of corneal epithelial defect, as stained by fluorescence. Overall, six out of seven eyes had fluorescence staining scores < 5. Moreover, best corrected visual acuity, intraocular pressure, Schirmer’s test and Cochet-Bonnet corneal perception test results showed no significant improvement. An increase in corneal nerve density was observed by in vivo confocal microscopy after 8 weeks of CTH-mNGF treatment in three out of seven eyes. This study demonstrates that CTH-mNGF is transparent, thermosensitive, and has sustained-release properties. Its effectiveness in healing corneal epithelial defects in all eyes with neurotrophic keratopathy suggests CTH-mNGF has promising application prospects in the treatment of neurotrophic keratopathy, being convenient and cost effective.