bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yarning about river safety: A qualitative study exploring water safety beliefs and practices for First Nations People
Authors: Williams Jasmine , McMillan Faye , Peden Amy E. 
Published: August 2023

AbstractIssue AddressedWater is vital to Australian First Nations Peoples' connection to country and culture. Despite this cultural significance, and epidemiological studies identifying elevated drowning risk among Australian First Nations Peoples, extremely limited qualitative research explores water safety beliefs and practices of First Nations Peoples. This study addressed this knowledge gap via qualitative research with Wiradjuri people living in Wagga Wagga, New South Wales.MethodsUnder Aboriginal Reference Group guidance, a local researcher recruited participants using purposive sampling for yarning circles across four groups: young people aged 18–30 years, parents of children under 5, parents of older children and adolescents and Elders. Yarning circles were audio recorded, transcribed and thematically coded using an inductive approach.ResultsIn total, 10 First Nations individuals participated. Yarning led to rich insights and yielded five themes: families as first educators; importance of storytelling, lived experience and respect for knowledge holders; the river as a place of connection; historical influence on preference for river over pool and river is unpredictable and needs to be respected.ConclusionsThis study demonstrates the importance of First Nations culture to water safety practices, particularly around the river. To reduce drowning risk among First Nations populations, knowledge holders need to be embedded in the design and delivery of community water safety education.So What?Co‐designing water safety initiatives with First Nations Peoples will have dual benefits; developing culturally appropriate and locally relevant water safety education, while also continuing First Nations culture across generations.
South Australia's tobacco retail landscape and its intersection with socioeconomic factors and smoking prevalence
Authors: Morris Julia N. , Baldock Jennifer , Trigg Joshua , Blunt Jason , Blanden Liam 
Published: August 2023

AbstractIssues AddressedTobacco product availability is higher in socioeconomically disadvantaged areas, which can further widen tobacco‐related health and disease burden inequities. This study aimed to describe retail availability of tobacco products in South Australia and examine the association between tobacco vendor location, population's socioeconomic status (SES) and tobacco smoking prevalence.MethodsCross‐sectional 2022 tobacco vendor licence data and 2021–2022 state‐wide population health survey data from the South Australian Department of Health were used. Tobacco vendors were enumerated by Statistical Area 2 (SA2) using geocoding software, with SA2s assigned health survey derived smoking prevalence, SES, remoteness category, area size, and population size.ResultsAs of 2022, there were 1723 tobacco vendors in South Australia and the overall tobacco smoking prevalence across the state was 11.8%. Regression analyses indicated that tobacco vendor density increased with socioeconomic disadvantage and geographic remoteness, and that smoking prevalence was higher in low SES areas. Vendor density was not related to smoking prevalence.ConclusionsFindings are consistent with existing research indicating greater tobacco availability in socially disadvantaged areas. This supports that tobacco vendor saturation may be directed to areas in a way that promotes tobacco availability for vulnerable populations. Our finding that smoking prevalence was unrelated to tobacco availability contrasts existing literature and should be carefully interpreted.So What?This is the first study to map tobacco retailers across South Australia, contributing needed evidence on the intersection of tobacco vendor density, social disadvantage, and smoking prevalence.
Seroprevalence and associated risk factors of hepatitis C infection among diabetic patients in South‐Kivu, Eastern Democratic Republic of the Congo: A cross‐sectional study
Authors: Birato Yannick Chibinda , Shindano Tony Akilimali , Cinyabuuma Daudi , Abel Ciza , Chiruza Cikomola Justin , Bulabula Andre N. H. 
Published: August 2023

AbstractBackground and AimsHepatitis C virus (HCV) infection and diabetes mellitus (DM) are two frequent diseases in the Democratic Republic of the Congo (DRC) and several studies seem to show a link between the two diseases worldwide. However, no study has evaluated this link in our country. The present study aimed at determining the seroprevalence of HCV in diabetic patients as well as associated risk factors.MethodologyA multicenter cross‐sectional study allowed us to sample diabetic patients in two diabetic healthcare centers of Bukavu city in the eastern part of the DRC, from December 2020 to December 2022. A questionnaire was submitted to the diabetic patients to collect sociodemographic data, anamnestic data on risk factors for HCV infection, and clinical data on DM. These factors were analyzed based on anti‐HCV serological results.ResultsAmong the 180 selected patients, 19 (10.6%) were tested positive for anti‐HCV antibodies. After multivariate analysis, the identified factors influencing these outcomes were male sex (adjusted odds ratio [aOR]: 3.5, p = 0.027), dental extraction (aOR: 7.6, p = 0.001), and living in a privileged environment (aOR: 0.29, p = 0.03). The factors related to DM such as the type, the disease duration, or the usual type of treatment did not influence the serological results.ConclusionThis study shows that HCV seroprevalence in diabetic patients is very high compared with the general population. This suggests combined screening and management policies in this population.
A new CECR1 mutation associated with severe hematological involvement in ADA2 deficiency
Authors: Nicoară Delia , Niță Cristina , Stanilă Ana , Martiniuc Alexandru , Popa Laura , Petrescu Eliana , Bătăneant Mihaela , Ciofu Ruxandra , Guriță Adriana , Tabăcaru Radu , Ionescu Ruxandra , Groșeanu Laura 
Published: August 2023

AbstractBackgroundThe deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessively inherited disease resulting from loss‐of‐function mutations in ADA2, formerly named CECR1 (cat eye syndrome chromosome region, candidate 1) gene. Disease manifestations could be separated into three major phenotypes: inflammatory/vascular, immune dysregulatory, and hematologic; however, most patients presented with significant overlap between these three phenotype groups.Case PresentationWe present a case of DADA2 deficiency with disease onset at 3 years old, not recognized till the age of 18 with severe gastrointestinal vasculitis and recurrent episodes of neutropenia associated with a new CECR1 mutation.
A prospective cohort study identifies two types of HIV+ Kaposi Sarcoma lesions: proliferative and inflammatory
Authors: Moorad Razia , Kasonkanji Edwards , Gumulira Joe , Gondwe Yolanda , Dewey Morgan , Pan Yue , Peng Alice , Pluta Linda J. , Kudowa Evaristar , Nyasosela Richard , Tomoka Tamiwe , Tweya Hannock , Heller Tom , Gugsa Salem , Phiri Sam , Moore Dominic T. , Damania Blossom , Painschab Matthew , Hosseinipour Mina C. , Dittmer Dirk P. 
Published: August 2023

AbstractKaposi sarcoma (KS) is the most common cancer in people living with HIV (PLWH) in many countries where KS‐associated herpesvirus is endemic. Treatment has changed little in 20 years, but the disease presentation has. This prospective cohort study enrolled 122 human immunodeficiency virus (HIV) positive KS patients between 2017 and 2019 in Malawi. Participants were treated with bleomycin, vincristine and combination antiretroviral therapy, the local standard of care. One‐year overall survival was 61%, and progression‐free survival was 58%. The 48‐week complete response rate was 35%. RNAseq (n = 78) differentiated two types of KS lesions, those with marked endothelial characteristics and those enriched in inflammatory transcripts. This suggests that different KS lesions are in different disease states consistent with the known heterogeneous clinical response to treatment. In contrast to earlier cohorts, the plasma HIV viral load of KS patients in our study was highly variable. A total of 25% of participants had no detectable HIV; all had detectable KSHV viral load. Our study affirms that many KS cases today develop in PLWH with well‐controlled HIV infection and that different KS lesions have differing molecular compositions. Further studies are needed to develop predictive biomarkers for this disease.
Randomized, two‐arm, noncomparative phase 2 study of olaparib plus cediranib or durvalumab in HRR‐mutated, platinum‐resistant ovarian cancer: A substudy of KGOG 3045
Authors: Kim Yoo‐Na , Joung Je‐Gun , Park Eunhyang , Kim Jae‐Weon , Lee Jung Bok , Lim Jinyeong , Kim Sunghoon , Choi Chel Hun , Kim Hee Seung , Chung Jongsuk , Kim Byoung‐Gie , Lee Jung‐Yun 
Published: August 2023

AbstractChoosing an optimal concomitant drug for combination with poly‐ADP ribose polymerase (PARP) inhibitor based on patient‐specific biomarker status may help increase to improve treatment efficacy in patients with ovarian cancer. However, the efficacy and safety of different PARP inhibitor‐based combinations in patients with homologous recombination repair (HRR) mutations have not been evaluated in ovarian cancer. In this sub‐study of Korean Gynecologic Oncology Group (KGOG) 3045, we compared the efficacy and safety of two olaparib‐based combinations and biomarkers of patients with platinum‐resistant ovarian cancer with HRR gene mutations. Patients were randomized to receive either olaparib (200 mg twice a day) + cediranib (30 mg daily) (Arm 1, n = 16) or olaparib (300 mg) + durvalumab (1,500 mg once every 4 weeks) (Arm 2, n = 14). The objective response rates for Arm 1 and Arm 2 were 50.0% and 42.9%, respectively. Most patients (83.3%) had BRCA mutations, which were similarly distributed between arms. Grade 3 or 4 treatment‐related adverse events were observed in 37.5% and 35.7% of the patients, respectively, but all were managed properly. A high vascular endothelial growth factor signature was associated with favorable outcomes in Arm 1, whereas immune markers (PD‐L1 expression [CPS ≥10], CD8, neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio) were associated with favorable outcomes in Arm 2. The activation of homologous recombination pathway upon disease progression was associated with poor response to subsequent therapy. Based on comprehensive biomarker profiling, including immunohistochemistry, whole‐exome and RNA sequencing and whole blood‐based analyses, we identified biomarkers that could help inform which of the two combination strategies is appropriate given a patient's biomarker status. Our findings have the potential to improve treatment outcome for patients with ovarian cancer in the PARP inhibitor era.
Corporate governance, Shari'ah governance and financial flexibility: Evidence from the MENA region
Authors: Aljughaiman Abdullah , Salama Aly , Verousis Thanos 
Published: August 2023

AbstractThis article investigates the relationship between corporate governance structures and financial flexibility for conventional and Islamic banks in the Middle East and North Africa (MENA) region. We construct a novel financial flexibility index (FFI) for the banking sector and examine the impact of the Shari'ah supervisory board (SSB), board size, and risk governance on financial flexibility. We find that board size and risk governance significantly affect banks' financial flexibility for Islamic and conventional banks. However, Shari'ah governance rules determine how that relationship is manifested in Islamic banks. We show that SSB size and busy SSBs enhance Islamic banks' financial flexibility. Our results show that Western corporate governance structures may lead to suboptimal financial flexibility. Banking policies should re‐evaluate the impact of one‐size‐fits‐all approaches to corporate governance while promoting ‘soft policies’ to banking regulation that are value‐enhancing for the banking sector.
Parental sensitivity, family alliance and infants’ vagal tone: Influences of early family interactions on physiological emotion regulation
Authors: Rattaz Valentine , Tissot Hervé , Puglisi Nilo , Razurel Chantal , Epiney Manuella , Favez Nicolas 
Published: August 2023

AbstractIn this study, we investigated the influence of parental sensitivity and family alliance on infants’ vagal tone, considered as a physiological indicator of emotion regulation. Studies on mother–infant interactions have shown that vagal tone can be influenced by the quality of the interaction, such as interacting with a sensitive mother. To date, no study has investigated the influence of paternal sensitivity or family alliance on infants’ vagal tone. We hypothesized that maternal sensitivity, paternal sensitivity, and family alliance would be associated with infants’ vagal tone during dyadic and triadic interactions. We also explored if family alliance would act as a moderator on the association between parental sensitivity and vagal tone and if the sensitivity of both parents would act as a moderator on the association between family alliance and vagal tone. This study took place in Switzerland and included 82 families with their 3–4‐month‐old infants. Results showed that maternal sensitivity and family alliance were associated with infants’ vagal tone, but paternal sensitivity was not. We found no significant moderation effect. However, result tendencies suggested that the contribution of paternal sensitivity to infants’ emotion regulation could be influenced by family alliance, whereas maternal sensitivity and family alliance have a unique contribution.
Research and innovation in agricultural water management for a water‐secure world
Authors: Smith Mark D. , Sikka Alok , Dirwai Tinashe L. , Mabhaudhi Tafadzwanashe 
Published: August 2023

AbstractThere is increased awareness that the current food system is unsustainable and that transformative research, development and innovation in agricultural water management (AWM) are needed to transform water and food systems under climate change. We provide an overview of research efforts, challenges, opportunities and innovations to improve water resource management and sustainability, especially in the agricultural sector. We highlight how sustainable AWM is central to balancing the needs of a growing population and increasing food demand under increasing water insecurity and scarcity, with environmental and socio‐economic outcomes. Innovative technologies are being developed to optimize water use and productivity through sustainable irrigation technologies, irrigation modernization and smart water management. However, these innovations still need to fully address equity, inequality and social justice concerning access to water, infrastructure and the delayed technological advances in the global South. This requires adopting transdisciplinary approaches, as espoused by the water–energy–food (WEF) nexus, to better anticipate and balance trade‐offs, optimize synergies and mitigate risks of maladaptation. Through such transdisciplinary approaches, AWM innovations could better consider local socio‐economic, governance, institutional and technological constraints, thus allowing for more contextualized and relevant innovations that can be scaled.
Ethyl maltol disrupt iron homeostasis in SH‐SY5Y neuroblastoma cell line
Authors: Sun Yuchen , Bressler Joseph 
Published: August 2023

AbstractEthyl Maltol (EM) is a commonly used flavoring compound and has been reported to bind iron and facilitate iron transport. Since EM is membrane permeable, the potential that it disrupts intracellular iron homeostasis was investigated. EM increased the labile iron pool in SH‐SY5Y cells and increased iron‐responsive protein activity using a reporter assay in the HEK293 cells. EM induced the expression of transferrin receptor 1 messenger RNA (mRNA) and decreased the expression of ferritin light chain protein in SH‐SY5Y cells. Expression of the iron‐responsive amyloid precursor protein attenuated the effects of EM on these iron‐responsive genes. EM treatment decreased cell viability and increased DNA damage. EM also increased the level of phosphorylated p53 and the expression of the p53‐regulated genes, p21, and 14‐3‐3σ. The expression of amyloid precursor protein (APP) attenuated the effects of EM on viability, DNA damage, and the p53 response. Overall, we suggest that EM decreases cell viability through a mechanism involving the p53 pathway. The attenuated responses observed in cells expressing APP suggest that the effects of EM are due to disrupting iron homeostasis.
Endocrine‐disrupting compounds and metabolomic reprogramming in breast cancer
Authors: Winz Cassandra , Zong Wei‐Xing , Suh Nanjoo 
Published: August 2023

AbstractEndocrine‐disrupting chemicals pose a growing threat to human health through their increasing presence in the environment and their potential interactions with the mammalian endocrine systems. Due to their structural similarity to hormones like estrogen, these chemicals can interfere with endocrine signaling, leading to many deleterious effects. Exposure to estrogenic endocrine‐disrupting compounds (EDC) is a suggested risk factor for the development of breast cancer, one of the most frequently diagnosed cancers in women. However, the mechanisms through which EDCs contribute to breast cancer development remain elusive. To rapidly proliferate, cancer cells undertake distinct metabolic programs to utilize existing nutrients in the tumor microenvironment and synthesize macromolecules de novo. EDCs are known to dysregulate cell signaling pathways related to cellular metabolism, which may be an important mechanism through which they exert their cancer‐promoting effects. These altered pathways can be studied via metabolomic analysis, a new advancement in ‐omics technologies that can interrogate molecular pathways that favor cancer development and progression. This review will summarize recent discoveries regarding EDCs and the metabolic reprogramming that they may induce to facilitate the development of breast cancer.
Highly selective reduction of nitro compounds catalyzed by MOF‐derived glucose stabilized Fe3O4 under mild conditions
Authors: Bisafar Masoumeh Bagheri , Malmir Masoume , Heravi Majid M. 
Published: August 2023

AbstractBACKGROUNDToday, studies on the catalytic reduction of nitroarenes and dyes are of crucial because nitroarenes, especially 4‐nitrophenol (4‐NPh) and dyes, which are considered important pollutants in wastewater, can pose risks to humans. It is noteworthy that amines are known as valuable intermediates in many industries, therefore, providing an efficient method to achieve these compounds is necessary to protect the environment. In this project, a magnetic MOFs‐based catalyst (containing Cu species as an active site) was found to offer a unique and cost‐effective route for the catalytic reduction of nitroarene and organic dyes.RESULTSIn this study, a novel magnetic catalyst, Fe3O4@glu/Cu‐TAZ‐IMI, based on MOF was synthesized. The core‐shell structure of Fe3O4@glu, functionalized with aspartic acid with TAZ‐IMI and Cu(OAc)2, resulted in the formation of magnetic MOF structure. The structure of this new nanocomposite was identified by X‐ray diffraction (XRD), Fourier Transform Infrared Spectrometer (FTIR), Brunauer–Emmett–Teller (BET), Scanning electron microscopy/energy dispersive X‐ray (SEM/EDX), Thermogravimetric analysis (TGA), High‐resolution transmission electron microscopy (HRTEM), Value stream mapping (VSM), Raman spectroscopy and Inductively coupled plasma‐optical emission spectrometry (ICP‐OES). The catalytic performance of the synthesized catalyst was evaluated for the reduction of nitro compounds and organic dyes, and the results were validated by Gas chromatography‐mass (GC–MS) and ultraviolet light (UV–Vis) spectroscopy. Moreover, the rate constants for the reduction of 4‐NPh, Congo red (CR), and Methylene blue (MB) followed pseudo first‐order kinetics model, which calculated values of 0.31 min−1, 0.355 min−1 and 0.044 s−1, respectively.CONCLUSIONThe catalytic efficacy of Fe3O4@glu/Cu‐TAZ‐IMI catalyst remained intact during the reduction of nitroarenes and organic dyes in aqueous and mild conditions. The findings demonstrate that this novel heterogeneous mesoporous catalyst exhibits exceptional catalytic activity and remarkable stability towards reduction reactions. Moreover, owning to its thermal and structural stability, the catalyst could be easily magnetically separated, recovered, and reused for up to 10 consecutive cycles without experiencing significant activity decline, effectively preventing the depletion of copper species from its structure. © 2023 Society of Chemical Industry.
Brain structural changes in alternating hemiplegia of childhood using single‐case voxel‐based morphometry analysis
Authors: Arizono Elly , Sato Noriko , Shigemoto Yoko , Kimura Yukio , Chiba Emiko , Maki Hiroyuki , Matsuda Hiroshi , Takeshita Eri , Shimizu‐Motohashi Yuko , Sasaki Masayuki , Saito Kazuhiro 
Published: August 2023

AbstractBackground and purposeAlternating hemiplegia of childhood (AHC) is a rare neurodevelopmental disease caused by ATP1A3 mutations. Using voxel‐based morphometry (VBM) analysis, we compared an AHC patient cohort with controls. Additionally, with single‐case VBM analysis, we assessed the associations between clinical severity and brain volume in patients with AHC.Materials and methodsTo investigate structural brain changes in gray matter (GM) and white matter (WM) volumes between 9 patients with AHC and 20 age‐matched controls, VBM analysis was performed using three‐dimensional T1‐weighted magnetic resonance imaging. Single‐case VBM analysis was also performed on nine patients with AHC to investigate the associations between the respective volumes of GM/WM differences and the motor level, cognitive level, and status epilepticus severity in patients with AHC.ResultsCompared with controls, patients with AHC showed significant GM volume reductions in both hippocampi and diffuse cerebellum, and there were WM reductions in both cerebral hemispheres. In patients with AHC, cases with more motor dysfunction, the less GM/WM volume of cerebellum was shown. Three of the six cases with cognitive dysfunction showed a clear GM volume reduction in the insulae. Five of the six cases with status epilepticus showed the GM volume reduction in hippocampi. One case had severe status epilepticus without motor dysfunction and showed no cerebellar atrophy.ConclusionWith single‐case VBM analysis, we could show the association between region‐specific changes in brain volume and the severity of various clinical symptoms even in a small sample of subjects.