bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhodium(II)‐Catalyzed Selective C(sp3)−H Amination of Alkanes
Authors: Boquet Vincent , Guimaraes Naves Junio A. , Brunard Erwan , Nasrallah Ali , Joigneaux Mylène , Sosa Carrizo E. Daiann , Saget Tanguy , Darses Benjamin , Sircoglou Marie , Dauban Philippe 
Published: July 2023

AbstractThe development of an efficient catalytic system enabling the conversion of alkanes to valuable nitrogen‐containing building blocks is reported. Light alkanes can be selectively functionalized by an intermolecular C(sp3)−H amination reaction that proceeds at room temperature in the presence of only 1 mol % of a dirhodium(II) complex. Selective amination of tertiary C(sp3)−H within acyclic or cyclic alkanes used as limiting components leads to the corresponding amides isolated with yields in the 51–96 % range. The reaction, that can be performed on a gram‐scale, applies with equal levels of efficiency and selectivity to more complex hydrocarbons.
Evaluation of the Stereochemical Lability of Benzo‐Cycloheptene‐Based Drugs Endowed with Potentially Modulable Planar Chirality
Authors: Buonsenso Fabio , Colombo Marta , Marchesi Andrea , Mammone Francesca Romana , Sannicolò Francesco , Cirilli Roberto , Pierini Marco 
Published: July 2023

AbstractAn experimental and theoretical study was carried out to analyze the configurational lability possessed by some of the most common drugs endowed with a central non‐planar seven‐membered cycloheptadiene ring, which confers chirality to these compounds. In fact, the absence of planarity allows the existence of two enantiomeric species that can interconvert thanks to a ring overturning mechanism. The energy barrier that opposes the inversion of the chiral tricyclic scaffold characterizing such species, which is strongly dependent on the presence of appropriate substituents on the two external cycles, has been investigated through Dynamic‐HPLC and off‐column racemization techniques, as well as through assessments based on molecular modelling approaches. Interesting indications were obtained by making targeted structural changes to allow accurate control of the stereolability characterizing the tricyclic framework.
When one's partner wants out: Awareness, attachment anxiety and accuracy
Authors: Tan Kenneth , Machia Laura V. , Agnew Christopher R. 
Published: July 2023

AbstractCan a person tell whether their romantic partner wants to break up and, if so, how is such accuracy associated with their own attachment anxiety? We examined these questions by proposing and assessing the construct of perceived partner dissolution consideration (PPDC), including its validity. We then assessed the extent to which partners were accurate in their perceptions of each other's dissolution consideration, focusing on the perceiver's attachment anxiety as a potential moderator. Specifically, in two studies involving couples, dyadic analyses of couple data showed that couple members significantly underestimated (negative mean‐level bias) partner dissolution consideration and also projected their own dissolution consideration onto their partners. Couple members higher in anxiety were particularly accurate (tracking accuracy) in their assessments of dissolution consideration. Implications for partner perceptions and judgements of dissolution consideration on relationship functioning are considered.
Hydrometric data rescue and extension of river flow records: Method development and application to catchments modified by arterial drainage
Authors: de Smeth Kate , Comer Joanne , Murphy Conor 
Published: July 2023

AbstractExtended hydrometric (water level and flow) records are presented for eight Irish catchments subject to arterial drainage. The procedures employed to collect and process historical data, extend flow records and compile key metadata and information about each gauging station are described. Procedures are developed to handle data quality issues related to hydrometric practices and equipment malfunction and to quality assure rescued data using quality codes that complement modern hydrometric practices. The workflow developed will assist other hydrometric data rescue efforts and minimize subjectivity during the rescue process. The newly extended records represent the longest continuous river flow series available in Ireland, extending to the commencement of formal hydrometric monitoring in the country in 1940. The resultant data sets add 150 years of daily data across eight stations and will provide a key new resource for hydrological studies into the impacts of arterial drainage and flow nonstationarity.
Spatially consistent physical characteristics of UK rivers: 1‐km data
Authors: Davies Helen N. , Rameshwaran Ponnambalam , Bell Victoria A. , Dadson Simon 
Published: July 2023

AbstractThe physical river characteristics datasets described here provide spatially consistent information to support hydrological and inundation modelling at a 1 km × 1 km resolution across the United Kingdom, on the British National Grid. The datasets of physical river characteristics provide gridded datasets (outflow drainage directions, catchment areas, widths of bankfull rivers and depths of bankfull rivers) and a comma‐separated table of NRFA (National River Flow Archive) gauging station locations. These datasets are derived from a range of sources: outflow drainage directions, catchment area and bankfull river widths are derived from existing higher resolution datasets, whereas bankfull river depths were harder to source and instead are derived from sparse historical measurements. The new gridded datasets provide a derived value for each UK land cell on the British National Grid (BNG). The comma‐separated NRFA gauging station locations table provides the most appropriate locations of 1,499 river flow gauging stations on the 1 km resolution grids, together with the approximate error in the 1 km × 1 km gridded delineation of the upstream catchment area. This article explains how UK‐wide 1‐km grids of these variables were estimated, their format and how to use them. The data are available from the Environmental Information Data Centre (EIDC).
Short‐chain fatty acids profile in patients with SARS‐CoV‐2: A case‐control study
Authors: Nabizadeh Edris , Memar Mohammad Yousef , Hamishehkar Hamed , Ghanbari Hadi , Kadkhoda Hiva , Asnaashari Solmaz , Kafil Hossein Samadi , Varshochi Mojtaba , Mostafazadeh Mostafa , Hosseinpour Rasoul , Ghotaslou Reza 
Published: July 2023

AbstractBackground and AimsSARS‐CoV‐2, as a new pandemic disease, affected the world. Short‐chain fatty acids (SCFAs) such as acetic, propionic, and butyric acids are the main metabolites of human gut microbiota. The positive effects of SCFAs have been shown in infections caused by respiratory syncytial virus, adenovirus, influenza, and rhinovirus. Therefore, this study aimed to evaluate the concentration of SCFAs in patients with SARS‐CoV‐2 compared with the healthy group.MethodsThis research was designed based on a case and control study. Twenty healthy individuals as the control group and 20 persons admitted to the hospital with a positive test of coronavirus disease (COVID‐19) real‐time polymerase chain reaction were included in the study as the patient group from September 2021 to October 2021, in Tabriz, Iran. Stool specimens were collected from volunteers, and analysis of SCFAs was carried out by a high‐performance liquid chromatography system.ResultsThe amount of acetic acid in the healthy group was 67.88 ± 23.09 μmol/g, while in the group of patients with COVID‐19 was 37.04 ± 13.29 μmol/g. Therefore, the concentration of acetic acid in the patient group was significantly (p < 0.001) lower than in the healthy group. Propionic and butyric acid were present in a higher amount in the control group compared with the case group; however, this value was not statistically significant (p > 0.05).ConclusionThis study showed that the concentration of acetic acid as the metabolite caused by gut microbiota is significantly disturbed in patients with COVID‐19. Therefore, therapeutic interventions based on gut microbiota metabolites in future research may be effective against COVID‐19.
Conjugate local thermal nonequilibrium and non‐Darcy flow inside porous enclosure: Analysis of localized heating and cooling arrangements
Authors: Alomar Omar Rafae , Basher Noor Moneer , Yousif Anwar Ahmed , Yousif Qais Abid 
Published: July 2023

AbstractThis study covers a simulation on conjugate free convective in a porous enclosure containing a side wall thickness and partially heated and cooled from sides under the considerations of local thermal nonequilibrium (LTNE) and non‐Darcy flow. Interest has been focused on how the side wall thickness and the locations of cooled and heated parts affect the effectiveness of the Nusselt number (Nu). Three different cases of localized heating and cooling locations have been implemented for the following ranges: scaled heat transfer coefficient (), wall to fluid thermal conductivity ratio (), modified Rayleigh number (), wall width (), inertial parameter (), and thermal conductivity ratio (). Outcomes show that and the locations of cooled and heated parts have remarkable impacts on all the Nusselt numbers. The intensity of LTNE region considerably relies on , and . The total average NuT is highly dependent on , , , , and as compared to H. The increase in leads to change of the convective mechanism to conductive mode. The rise in guides to increase Nu, where can control the flow strength. The actions of on Nuf is more evident than Nus. For low H and Kr, the size of LTNE zone is considerably affected by H as compared to Kr although Kr has a high influence on Nu. For high Kr and H, the LTNE zone has closely vanished. Findings display that the Case 2 provided the highest Nu for all tested parameters except the case of . Finally, it is evident that for the problems that employed solid conduction wall with localized heating and cooling sections, Case 2 is recommended for future use in the applications that implement a porous medium and depend on free convection.
Architectural design and electrochemical performance of MOF‐based solid‐state electrolytes for high‐performance secondary batteries
Authors: Yang Biao , Shi Yuxin , Kang Dae Joon , Chen Zhidong , Pang Huan 
Published: July 2023

AbstractNowadays solid‐state batteries have become a hot spot in the research of batteries and a significant candidate for commercial batteries for the increasing demands for good safety and excellent energy density. Metal‐organic frameworks (MOFs) have been considered as suitable materials for solid‐state electrolytes (SSEs) for the merits of regular channels and large specific surface areas, which can provide a promising structural platform for fast‐ion conduction. Therefore, numerous kinds of MOF‐based SSEs with enhanced electrochemical performance have been successfully synthesized and studied in recent years. In this review, the recent progress (synthesis methods, physical and chemical characteristics) of MOF‐based SSEs for secondary batteries have been summarized. Finally, the challenges and opportunities faced by the future development in this field are put forward, hoping to provide some enlightenment for the synthesis of MOF‐based SSEs, so as to create more efficient, long‐lasting, and safe SSE‐based secondary batteries.
A Tribute to Richard Lerner (1938–2021) who Encouraged a Glycobiology Approach to a Broad‐Spectrum Antiviral
Authors: Fotinou Constantina , Dwek Raymond A. 
Published: July 2023

AbstractRichard Lerner was a visionary polymath of the 20th century; a medical doctor, chemist, immunologist, inventor, and founder of new scientific fields. As a tribute to his life and scientific achievements, we discuss his connection with Oxford University and the Glycobiology Institute and we discuss our research data on the host glycoprotein folding pathway and how its inhibition can lead to broad spectrum antiviral drugs. This host targeting approach for developing antiviral therapies has the advantage of being effective against many viruses, therefore can be used to prevent new epidemics to become pandemics.
Bradykinin receptor participates in doxorubicin‐induced cardiotoxicity by modulating iNOS signal pathway
Authors: Chen Xueyan , Xie Kerang , Zhang Xiaofei , Gu Xinshun , Wu Yi , Su Suwen 
Published: July 2023

AbstractDoxorubicin (DOX), an effective and broad‐spectrum anthracycline antibiotic, is widely used in the treatment of numerous malignancies. However, dose‐dependent cardiotoxicity limits the clinical application of DOX, and the molecular mechanisms are still unknown. In this study, we used the BK receptor B1/B2 double‐knockout (B1B2‐/‐) mice to observe the role of BK receptor in cardiotoxicity induced by DOX and the underlying mechanisms. DOX induced myocardial injury with increased serum levels of AST, CK, and LDH, upregulated tissue expression of bradykinin B1/B2 receptor, FABP4 and iNOS, and downregulated expression of eNOS. However, these altered releases of myocardial enzyme and the expression level of iNOS were significantly prevented in the B1B2‐/‐ mice. We concluded that the activation of both B1 and B2 receptors of BK were involved in the DOX‐induced acute myocardial injury, possibly mediated through iNOS signaling pathways.
Disproportionality Analysis on Hypothyroidism With Roxadustat Using the Japanese Adverse Drug Event Database
Authors: Kouki Yasunobu , Okada Naoto , Saga Kosuke , Ozaki Masakazu , Saisyo Atsuyuki , Kitahara Takashi 
Published: July 2023

AbstractHypoxia‐inducible factor prolyl‐hydroxylase inhibitor (HIF‐PHI) is a novel agent for the treatment of renal anemia. HIF‐PHI increases endogenous erythropoietin production by inhibiting the degradation of an erythropoietin transcription factor. Although beneficial effects are expected from HIF‐PHI, its novel mechanism raises concerns regarding the risk of potential adverse events. The cases of hypothyroidism, which had not been reported in clinical trials, were reported after the administration of roxadustat in a real‐world setting. However, the effects of HIF‐PHIs on thyroid function have not yet been fully evaluated. This study aimed to assess the clinical impact of HIF‐PHIs on thyroid function using the Japanese Adverse Drug Event Report database, a spontaneous reporting system in Japan, because HIF‐PHIs were made available in Japan before they were available in other countries. Although a disproportionality signal for hypothyroidism was detected with roxadustat (reporting odds ratio [ROR]:22.1, 95% confidence interval [CI]:18.3‐26.7, no signals were detected with another HIF‐PHI, daprodustat (ROR:1.3, 95%CI:0.3‐5.4), and epoetin beta pegol (ROR:1.2, 95%CI:0.5‐2.7). Signals of hypothyroidism due to roxadustat were also detected regardless of age or sex. Approximately 50% of hypothyroidism cases were reported within 50 days of starting roxadustat use. These results indicate that roxadustat use may be related to the development of hypothyroidism. The need for monitoring of thyroid function should be alerted during roxadustat administration regardless of age or sex.
Application of concept maps as an assessment tool in engineering education: Systematic literature review
Authors: Jackson Alexandra , Barrella Elise , Bodnar Cheryl 
Published: July 2023

AbstractBackgroundConcept maps are a valid assessment tool to explore student understanding of diverse topics. Many types of academic programs have integrated concept mapping into their courses, resulting in various activities and scoring methods to understand student perceptions.PurposeFew prior reviews of concept mapping have addressed their use within engineering education. This systematic literature review examines articles that use concept mapping as an assessment tool in engineering education contexts and provides suggestions for future research.Scope/MethodWe conducted a literature search using terms related to concept map and engineering education. Articles were screened by their title, abstract, section, and then full paper, resulting in 53 articles for the final review. Two researchers examined the topic, activity type, and scoring method of the maps.ResultsConcept mapping topics fit into three categories, and the activity structures fit into four types. Of seven scoring methods, “Traditional” was the most used. Studies that compared multiple scoring methods showed that the “Holistic” and “Categorical” methods were better able to capture the content of the maps. All types of scoring demonstrated positive outcomes, suggesting that concept maps can demonstrate understanding of the topic and can assess learning.ConclusionsConcept maps have been applied in a number of ways. All types of concept mapping scores were shown to be useful and can lead to a better understanding of the students' learning outcomes. However, more research is needed to determine which scoring methods are recommended for specific applications.
Facilitating person‐centred care: integrating an electronic client feedback tool into continuous quality improvement processes to deliver client‐responsive HIV services in the Democratic Republic of Congo
Authors: Tendo‐Bugondo Cyprien , Lieke Oséé , Kasongo Pierre , Diur Baudouin , Canagasabey Davina S. , Thior Ibou , Milenge Pascal K. , Kiluba Jean‐Claude 
Published: July 2023

AbstractIntroductionEngaging communities in the design, implementation and monitoring of health services is critical for delivering high‐quality, person‐centred services that keep people living with HIV engaged in care. The USAID‐funded Integrated HIV/AIDS Project in Haut‐Katanga (IHAP‐HK) integrated an electronic client feedback tool into continuous quality improvement (CQI) processes. We aimed to demonstrate this system's impact on identifying and improving critical quality‐of‐care gaps.MethodsThrough stakeholder and empathy mapping, IHAP‐HK co‐designed a service quality monitoring system—comprising anonymous exit interviews and ongoing monitoring through CQI cycles—with people living with HIV, facility‐based providers and other community stakeholders. IHAP‐HK trained 30 peer educators to administer oral, 10‐ to 15‐minute exit interviews with people living with HIV following clinic appointments, and record responses via the KoboToolbox application. IHAP‐HK shared client feedback with facility CQI teams and peer educators; identified quality‐of‐care gaps; discussed remediation steps for inclusion in facility‐level improvement plans; and monitored implementation of identified actions. IHAP‐HK tested this system at eight high‐volume facilities in Haut‐Katanga province from May 2021 through September 2022.ResultsFindings from 4917 interviews highlighted wait time, stigma, service confidentiality and viral load (VL) turnaround time as key issues. Solutions implemented included: (1) using peer educators to conduct preparatory tasks (pre‐packaging and distributing refills; pulling client files) or escort clients to consultation rooms; (2) limiting personnel in consultation rooms during client appointments; (3) improving facility access cards; and (4) informing clients of VL results via telephone or home visits. Due to these actions, between initial (May 2021) and final interviews (September 2022), client satisfaction with wait times improved (76% to 100% reporting excellent or acceptable wait times); reported cases of stigma decreased (5% to 0%); service confidentiality improved (71% to 99%); and VL turnaround time decreased (45% to 2% informed of VL results 3 months after sample collection).ConclusionsOur results showed the feasibility and effectiveness of using an electronic client feedback tool embedded in CQI processes to collect client perspectives to improve service quality and advance client‐responsive care in the Democratic Republic of Congo. IHAP‐HK recommends further testing and expansion of this system to advance person‐centred health services.
Assessing Pleistocene–Holocene climatic and environmental change in insular Near Oceania using stable isotope analysis of archaeological fauna
Authors: Roberts Patrick , Hixon Sean , Hamilton Rebecca , Lucas Mary , Ilgner Jana , Marzo Sara , Hawkins Stuart , Luu Sindy , Gosden Chris , Spriggs Matthew , Summerhayes Glenn 
Published: July 2023

ABSTRACTIn comparison to temperate and arid regions, environmental responses to the Last Glacial Maximum and the Terminal Pleistocene and Holocene boundary remain poorly known for many parts of the tropics, making it challenging to unravel human–landscape interactions across this timeframe. This is particularly the case in insular Near Oceania, where sea‐level fluctuations and potential changes in forest cover may have had major impacts on hunter–gatherer populations. Here, we apply stable carbon and oxygen isotope analyses to small‐mammal teeth from four Pleistocene–Holocene (spanning from 29 000 years ago to the late Holocene) sequences in the Bismarck Archipelago to reconstruct changes in environments directly exploited by human populations in this part of the world. Our results show a subtle response of tropical habitats in Near Oceania to relatively arid conditions during the late‐glacial period, something that has also been observed at sites in South and Southeast Asia, followed by a Terminal Pleistocene–Holocene expansion of tropical forest cover. Nevertheless, site‐based variability in environmental responses across this period highlight the need for more multidisciplinary studies of human occupation sequences in a region that is becoming increasingly central to exploring human adaptations, environmental modifications and social network development over the past 20 000 years.
Protective effect of Limosilactobacillus reuteri‐fermented yogurt on mouse intestinal barrier injury induced by enterotoxigenic Escherichia coli
Authors: Lu Xi , Zhang Mingxin , Ma Yuzhe , Li Guohua , Zhao Xin , Qian Weisheng 
Published: July 2023

AbstractBackgroundEnterotoxigenic Escherichia coli (ETEC) is a pathogen that causes traveler's diarrhea, for which an effective vaccine is lacking. Previous studies showed that Limosilactobacillus reuteri could inhibit E. coli, effectively increase the expression of its tight junction protein, and reduce the adhesion of ETEC to the intestinal epithelial Caco‐2 cell line. In this study, three kinds of yogurt with different starter cultures were first prepared: Lm. reuteri yogurt (fermented by Lm. reuteri alone), traditional yogurt (fermented by Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus at a ratio of 1:1) and mixed yogurt (fermented by Lm. reuteri, S. thermophilus and L. delbrueckii subsp. bulgaricus at a ratio of 1:1:1). The physiological properties, oxidative stress, intestinal barrier function, tight junction protein, pathological conditions and intestinal microbiota composition were investigated.ResultsThe data showed that Lm. reuteri‐fermented yogurt pregavage could effectively alleviate the intestinal barrier impairment caused by ETEC in mice. It alleviated intestinal villus shortening and inflammatory cell infiltration, decreased plasma diamine oxidase concentration and increased claudin‐1 and occludin expression in the jejunum of ETEC‐infected mice. In addition, Lm. reuteri‐fermented yogurt significantly reduced the ETEC load in fecal samples, reversed the increase in Pseudomonadota abundance and decreased Bacteroidota abundance caused by ETEC infection. Furthermore, the composition of the intestinal microbiota could maintain a stable state similar to that in healthy mice.ConclusionThese findings indicate that Lm. reuteri‐fermented yogurt could alleviate intestinal barrier damage, inhibit ETEC growth and maintain the stability of the intestinal microbiota during ETEC infection. © 2023 Society of Chemical Industry.