bluuebunny/crossref_metadata_2025_split huggingface dataset:
A machine learning q‐RASPR approach for efficient predictions of the specific surface area of perovskites**
Authors: Banerjee Arkaprava , Gajewicz‐Skretna Agnieszka , Roy Kunal 
Published: January 2023

AbstractIn this study, the specific surface area of various perovskites was modeled using a novel quantitative read‐across structure‐property relationship (q‐RASPR) approach, which clubs both Read‐Across (RA) and quantitative structure‐property relationship (QSPR) together. After optimization of the hyper‐parameters, certain similarity‐based error measures for each query compound were obtained. Clubbing some of these error‐based measures with the previously selected features along with the Read‐Across prediction function, a number of machine learning models were developed using Partial Least Squares (PLS), Ridge Regression (RR), Linear Support Vector Regression (LSVR), Random Forest (RF) regression, Gradient Boost (GBoost), Adaptive Boosting (Adaboost), Multiple Layer Perceptron (MLP) regression and k‐Nearest Neighbor (kNN) regression. Based on the repeated cross‐validation as well as external prediction quality and interpretability, the PLS model (nTraining = 38, nTest = 12,
=0.737,
was selected as the best predictor which underscored the previously reported results. The finally selected model should efficiently predict specific surface areas of other perovskites for their use in photocatalysis. The new q‐RASPR method also appears promising for the prediction of several other property endpoints of interest in materials science.
Effect of behavioral weight‐loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial
Authors: Collins Katherine A. , Kraus William E. , Rogers Renee J. , Hauser Elizabeth R. , Lang Wei , Jiang Rong , Schelbert Erik B. , Huffman Kim M. , Jakicic John M. 
Published: January 2023

AbstractObjectiveThis study aimed to determine whether novel biomarkers of cardiometabolic health improve in response to a 12‐month behavioral weight‐loss intervention and to compare benefits of diet alone with diet plus physical activity for these biomarkers.MethodsParticipants (N = 374) were randomized to either diet alone (DIET), diet plus 150 min/wk of prescribed moderate‐intensity physical activity (DIET + PA150), or diet plus 250 min/wk of prescribed moderate‐intensity physical activity (DIET + PA250). Biomarker concentrations were determined using nuclear magnetic resonance spectroscopy. Mixed models assessed for a time effect, group effect, or group by time interaction.ResultsAll groups significantly improved body weight (time: p < 0.0001), Lipoprotein Insulin Resistance Index score (time: p < 0.0001), Diabetes Risk Index score (time: p < 0.0001), branched‐chain amino acid concentration (time: p < 0.0001), and GlycA concentration (time: p < 0.0001), with no group effect or group by time interactions.ConclusionsAll intervention groups prompted a notable beneficial change among biomarkers of insulin resistance and cardiometabolic health. However, the addition of at least moderate‐intensity physical activity to a diet‐only intervention did not provide any additional benefit. These findings highlight that an average weight loss of approximately 10% profoundly impacts biomarkers of insulin resistance and cardiometabolic disease in adults with overweight or obesity.
Real‐world weight‐loss effectiveness of glucagon‐like peptide‐1 agonists among patients with type 2 diabetes: A retrospective cohort study
Authors: White Gretchen E. , Shu Ingrid , Rometo David , Arnold Jon , Korytkowski Mary , Luo Jing 
Published: January 2023

AbstractObjectiveWeight loss achieved with standard doses of glucagon‐like peptide‐1 (GLP‐1) agonists among real‐world patients with type 2 diabetes has not been determined. This study sought to describe the percent change in body weight 72 weeks after starting a GLP‐1 agonist.MethodsA retrospective cohort study of nonpregnant adults who were first dispensed a GLP‐1 agonist between 2011 and 2018 was conducted using electronic health record data from patients receiving care at a large health system. Linear mixed models were used, with a person‐level random intercept controlling for baseline variables associated with missing weight data to estimate percent body weight change during follow‐up.ResultsThe cohort included 2405 patients (mean [SD] age 48 [10] years, 53% female), with a mean BMI of 37 (8) kg/m2 and a mean baseline weight of 238 (54) lb. Mean percent weight loss significantly increased from 1.1% (95% CI: 0.6%‐1.6%) 8 weeks after GLP‐1‐agonist dispensing to 2.2% (95% CI: 1.7%‐2.6%) 72 weeks after GLP‐1‐agonist dispensing (p value for quadratic trend < 0.001). One‐third of patients lost ≥5% body weight at 72 weeks.ConclusionsIn this real‐world study of more than 2400 patients with overweight or obesity and type 2 diabetes, starting a GLP‐1 agonist at standard glycemic control doses was associated with modest weight loss through 72 weeks.
Maternal metabolomic profiling and congenital heart disease risk in offspring: A systematic review of observational studies
Authors: Mires Stuart , Reddy Snigdha , Skerritt Clare , Caputo Massimo , Eastwood Kelly‐Ann 
Published: January 2023

AbstractAetiological understanding and screening methods for congenital heart disease (CHD) are limited. Maternal metabolomic assessment offers the potential to identify risk factors and biomarkers. We performed a systematic review (PROSPERO CRD42022308452) investigating the association between fetal/childhood CHD and endogenous maternal metabolites. Ovid‐MEDLINE, Ovid‐EMBASE and Cochrane Library were searched between inception and 06/09/2022. Case control studies included analysing maternal blood or urine metabolites in pregnancy or postpartum where there was foetal/childhood CHD. Risk of bias assessment utilised the Scottish Intercollegiate Guidelines Network methodology checklist and narrative synthesis was performed. A total of 134 records were screened with eight eligible studies (n = 3242 pregnancies, n = 842 CHD‐affected offspring). Five studies performed metabolomic analysis in pregnancy. Metabolites distinguishing case and control groups spanned lipid, glucose and amino‐acid pathways, with the development of sensitive risk prediction models. No single metabolite consistently distinguished cases and controls across studies. Three studies performed targeted analysis postnatally with altered lipid and amino acid metabolites and raised homocysteine and markers of oxidative stress identified in cases. Included studies reported small sample sizes, analysing different biosamples at variable time points using differing techniques. At present, there is not enough evidence to confidently associate maternal metabolomic profiles with offspring CHD risk. However, several identified pathways warrant further investigation.
Zinc finger protein 330 regulates Ramie mosaic virus infection in the whitefly Bemisia tabaciMED
Authors: Peng Jing , Gao Yang , Shi Xiaobin , Yang Chunxiao , Xie Gang , Tang Tao , Wang Dongwei , Zheng Limin , Liu Yong , Zhang Deyong 
Published: January 2023

AbstractBACKGROUNDThe whitefly, Bemisia tabaci (Gennadius) is one of the most economically important pests that cause serious damage to agricultural production by transmitting plant pathogenic viruses. Approximately 90% of the virus species transmitted by the whitefly are members of the genus begomovirus. Ramie mosaic virus (RaMoV) is a new bipartite begomovirus that causes severe damage to ramie and several other economic crops in China. In previous studies, we have demonstrated that RaMoV had no obvious direct or indirect effects on B. tabaci. However, whether B. tabaci affects RaMoV infection and the molecular mechanisms of their interaction remain unclear.RESULTSHere, we identified a zinc finger protein 330 (ZNF330) in B. tabaci MED interacted with the coat protein (CP) of RaMoV by the yeast two‐hybrid assay. Then the interaction between ZNF330 and RaMoV CP was further verified by glutathione S‐transferase (GST) pull‐down assay. The expression of ZNF330 gene was continuously induced after RaMoV infection. ZNF330 negatively regulated RaMoV replication in the B. tabaci MED. Furthermore, the longevity and fecundity of RaMoV‐infected female adults were significantly decreased after silencing of ZNF330.CONCLUSIONSOur results indicated that the ZNF330 protein was involved in the negative regulation of RaMoV replication in the B. tabaci MED. High viral accumulation caused by ZNF330 silencing is detrimental to fecundity and longevity of the B. tabaci MED. These findings provided a new insight into identifying the binding partners in whitefly with viral CP and fully understanding the complex interactions between begomoviruses and their whitefly vector. © 2023 Society of Chemical Industry.
The novel pyridazine pyrazolecarboxamide insecticide dimpropyridaz inhibits chordotonal organ function upstream of TRPV channels
Authors: Spalthoff Christian , Salgado Vincent L. , Balu Narayanan , David Michael D. , Hehlert Philip , Huang Huazhang , Jones John E. , Kandasamy Ramani , Knudsen Gabriel A. , Lelito Katherine R. , Machamer James B. , Nesterov Alexandre , Tomalski Michael , Wahl Gregory D. , Wedel Barbara J. , Göpfert Martin C. 
Published: January 2023

AbstractBACKGROUNDPyridazine pyrazolecarboxamides (PPCs) are a novel insecticide class discovered and optimized at BASF. Dimpropyridaz is the first PPC to be submitted for registration and controls many aphid species as well as whiteflies and other piercing–sucking insects.RESULTSDimpropyridaz and other tertiary amide PPCs are proinsecticides that are converted in vivo into secondary amide active forms by N‐dealkylation. Active secondary amide metabolites of PPCs potently inhibit the function of insect chordotonal neurons. Unlike Group 9 and 29 insecticides, which hyperactivate chordotonal neurons and increase Ca2+ levels, active metabolites of PPCs silence chordotonal neurons and decrease intracellular Ca2+ levels. Whereas the effects of Group 9 and 29 insecticides require TRPV (Transient Receptor Potential Vanilloid) channels, PPCs act in a TRPV‐independent fashion, without compromising cellular responses to Group 9 and 29 insecticides, placing the molecular PPC target upstream of TRPVs.CONCLUSIONSPPCs are a new class of chordotonal organ modulator insecticide for control of piercing–sucking pests. Dimpropyridaz is a PPC proinsecticide that is activated in target insects to secondary amide forms that inhibit the firing of chordotonal organs. The inhibition occurs at a site upstream of TRPVs and is TRPV‐independent, providing a novel mode of action for resistance management. © 2023 BASF Corporation. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
A new large‐volume equilibration method for high‐precision measurements of dissolved noble gas stable isotopes
Authors: Ng Jessica , Tyne Rebecca , Seltzer Alan , Noyes Chandler , McIntosh Jennifer , Severinghaus Jeffrey 
Published: January 2023

RationaleNoble gases are widely used as physically based climate proxies, notably in dissolved water samples as tracers of past recharge temperature in groundwater and air–sea gas exchange processes in seawater. Recent advances in measuring large‐volume samples of dissolved noble gas isotopic ratios at high precision have expanded the range of climate parameters that can be interpreted.MethodsWe build on prior methods for measuring noble gas stable isotopes at high precision with a new large‐volume equilibration (LVE) method wherein sample gases are equilibrated in the sample flask between the dissolved phase and the headspace. The original dissolved gas composition is determined by measuring the headspace gases and correcting for the equilibrium dissolved gas content of the discarded water using known solubilities and fractionation factors. We evaluate the accuracy and precision of this method with air‐equilibrated water standards of known noble gas composition.ResultsReplicate air‐equilibrated water standards and field measurements demonstrate that the LVE method achieves comparable precision to prior methods, with major advantages of measuring the Ne content as a constraint on excess air and allowing for long‐term sample storage. Isotope ratios measured with the LVE method in replicate samples were consistent between two laboratories, and LVE elemental noble gas abundances agreed closely with replicate samples measured using established copper‐tube methods and static noble gas mass spectrometry.ConclusionsThe new LVE method enables reconstruction of past water table depths at ±1 m precision along with excess air, recharge temperature, and age and hydrogeochemical indicators. It has wide application to investigating climate signals and physical gas exchange processes in groundwater and seawater.
Efficacy and safety of tixagevimab‐cilgavimab as pre‐exposure prophylaxis for COVID‐19: A systematic review and meta‐analysis
Authors: Soeroto Arto Yuwono , Yanto Theo Audi , Kurniawan Andree , Hariyanto Timotius Ivan 
Published: January 2023

AbstractSome proportions of populations, such as immunocompromised patients and organ transplant recipients might have inadequate immune responses to the vaccine for coronavirus disease 2019 (COVID‐19). For these groups of populations, administering monoclonal antibodies might offer some additional protection. This review sought to analyze the effectiveness and safety of tixagevimab‐cilgavimab (Evusheld) as pre‐exposure prophylaxis against COVID‐19. We used specific keywords to comprehensively search for potential studies on PubMed, Scopus, Europe PMC, and ClinicalTrials.gov sources until 3 September 2022. We collected all published articles that analyzed tixagevimab‐cilgavimab on the course of COVID‐19. Review Manager 5.4 was utilized for statistical analysis. Six studies were included. Our pooled analysis revealed that tixagevimab‐cilgavimab prophylaxis may decrease the rate of SARS‐CoV‐2 infection (OR: 0.24; 95% CI: 0.15–0.40, p < 0.00001, I2 = 75%), lower COVID‐19 hospitalization rate (OR: 0.13; 95% CI: 0.07–0.24, p < 0.00001, I2 = 0%), decrease the severity risk (OR: 0.13; 95% CI: 0.07–0.24, p < 0.00001, I2 = 0%), and lower COVID‐19 deaths (OR: 0.17; 95% CI: 0.03–0.99, p = 0.05, I2 = 72%). In the included studies, no major adverse events were reported. This study proposes that tixagevimab‐cilgavimab was effective and safe for preventing COVID‐19. Tixagevimab‐cilgavimab may be offered to those who cannot be vaccinated or have inadequate immune response from the COVID‐19 vaccine to give additional protection.
In Situ Mesopore Formation in SiOx Nanoparticles by Chemically Reinforced Heterointerface and Use of Chemical Prelithiation for Highly Reversible Lithium‐Ion Battery Anode
Authors: Gong Sanghyuk , Lee Yeongje , Choi Jinkwan , Lee Minah , Chung Kyung Yoon , Jung Hun‐Gi , Jeong Sunho , Kim Hyung‐Seok 
Published: January 2023

AbstractSiOx is a promising next‐generation anode material for lithium‐ion batteries. However, its commercial adoption faces challenges such as low electrical conductivity, large volume expansion during cycling, and low initial Coulombic efficiency. Herein, to overcome these limitations, an eco‐friendly in situ methodology for synthesizing carbon‐containing mesoporous SiOx nanoparticles wrapped in another carbon layers is developed. The chemical reactions of vinyl‐terminated silanes are designed to be confined inside the cationic surfactant‐derived emulsion droplets. The polyvinylpyrrolidone‐based chemical functionalization of organically modified SiO2 nanoparticles leads to excellent dispersion stability and allows for intact hybridization with graphene oxide sheets. The formation of a chemically reinforced heterointerface enables the spontaneous generation of mesopores inside the thermally reduced SiOx nanoparticles. The resulting mesoporous SiOx‐based nanocomposite anodes exhibit superior cycling stability (≈100% after 500 cycles at 0.5 A g−1) and rate capability (554 mAh g−1 at 2 A g−1), elucidating characteristic synergetic effects in mesoporous SiOx‐based nanocomposite anodes. The practical commercialization potential with a significant enhancement in initial Coulombic efficiency through a chemical prelithiation reaction is also presented. The full cell employing the prelithiated anode demonstrated more than 2 times higher Coulombic efficiency and discharge capacity compared to the full cell with a pristine anode.
Carbon‐Based Flexible Devices for Comprehensive Health Monitoring
Authors: Wang Haomin , Li Shuo , Lu Haojie , Zhu Mengjia , Liang Huarun , Wu Xunen , Zhang Yingying 
Published: January 2023

AbstractTraditional public health systems suffer from incomprehensive, delayed, and inefficient medical services. Convenient and comprehensive health monitoring has been highly sought after recently. Flexible and wearable devices are attracting wide attention due to their potential applications in wearable human health monitoring and care systems. Using carbon materials with overall superiorities can facilitate the development of wearable and flexible devices with various functions and excellent performance, which can comprehensively and real‐time monitor human health status and prevent diseases. Herein, the latest advances in the rational design and controlled fabrication of carbon materials for applications in health‐related flexible and wearable electronics are reviewed. The fabrication strategies, working mechanism, performance, and applications in health monitoring of carbon‐based flexible devices, including electromechanical sensors, temperature/humidity sensors, chemical sensors, and flexible conductive wires/electrodes, are reviewed. Furthermore, integrating multiple carbon‐based devices into multifunctional wearable systems is discussed. Finally, the existing challenges and future opportunities in this field are also proposed.
A 3D Biocompatible Plasmonic Tweezer for Single Cell Manipulation
Authors: Kang Siyu , Nisar Muhammad Shemyal , Lu Yu , Chang Ning , Huang Yan , Ni Haibin , Novikov Sergey M. , Wang Yi , Cui Qiannan , Zhao Xiangwei 
Published: January 2023

AbstractPlasmonic tweezers are an emerging research topic because of their low input power and wide operating range from homogeneous particles to complex biological objects. But it is still challenging for plasmonic tweezers to trap or manipulate objects of tens of microns, especially in biological science. This study introduces a new 3D biocompatible plasmonic tweezer for single living cell manipulation in solution. The key design is a tapered tip whose three‐layer surface structure consists of nanoprobe, gold nanofilm, and thermosensitive hydrogel, thiolated poly(N‐isopropylacrylamide). Incident light excites the surface plasmon polaritons on gold film and generates heat to induce thermally driven phase transition of the thermosensitive hydrogel, which enables reversible binding between functionalized surface and cell membrane and avoids both thermal and mechanical stresses in the meanwhile. The 3D biocompatible plasmonic tweezer realizes selective capture, 3D pathway free transport, and position‐controlled release of target cells, and it displays excellent biocompatibility, low energy consumption, and high operational flexibility.
Matrine restrains the development of colorectal cancer through regulating the AGRN/Wnt/β‐catenin pathway
Authors: Li Xianzhe , Lu Ye , Wen Penghao , Yuan Yan , Xiao Zhenghong , Shi Hengwei , Feng Eryan 
Published: January 2023

AbstractBackgroundColorectal cancer is a common malignant digestive tract tumor. This study aimed to explore the biological role and potential underlying mechanism of matrine in colorectal cancer.MethodsThe mRNA expression of AGRN was measured using RT‐qPCR. Cell proliferation, migration, invasion and apoptosis were determined using CCK‐8, EdU, transwell assays and flow cytometry, respectively. Xenograft tumor experiment was performed to explore the action of matrine and AGRN on tumor growth in colorectal cancer in vivo. Immunohistochemistry (IHC) assay was applied for AGRN, β‐catenin, and c‐Myc expression in the tumor tissues from mice.ResultsMatrine dramatically repressed cell growth and reduced the level of AGRN in colorectal cancer cells. AGRN expression was boosted colorectal cancer tissues and cells. AGRN downregulation depressed cell proliferation, migration, invasion, and enhanced cell apoptosis in colorectal cancer cells. Moreover, matrine showed the anti‐tumor effects on colorectal cancer cells via regulating AGRN expression. AGRN knockdown could inactivate the Wnt/β‐catenin pathway in colorectal cancer cells. We found that AGRN downregulation exhibited the inhibition action in the progression of colorectal cancer by modulating the Wnt/β‐catenin pathway. In addition, matrine could inhibit the activation of the Wnt/β‐catenin pathway through regulating AGRN in colorectal cancer cells. Furthermore, xenograft tumor experiment revealed that matrine treatment or AGRN knockdown repressed the development of colorectal cancer via the Wnt/β‐catenin pathway in vivo.ConclusionMatrine retarded colorectal cancer development by modulating AGRN to inactivate the Wnt/β‐catenin pathway.
Me-Search for Generating Ideas for Entrepreneurial Theorizing
Authors: Shepherd Dean A. , Patzelt Holger 
Published: January 2023

AbstractThe future of the field of entrepreneurship is bright primarily because of the many research opportunities to make a difference. However, as scholars, how can we find these opportunities and choose the ones most likely to contribute to the literature? This essay introduces me-search as a tool for blazing new trails in entrepreneurship research. Me-search focuses scholarly attention on issues from one’s personal experiences as a useful tool for generating research opportunities in which one has idiosyncratic knowledge and is motivated to see it through to publication. In conducting me-search, we highlight the importance of solving a practical problem, problematizing, contextualizing, and abstracting entrepreneurship research, and using empirical theorizing to explore entrepreneurial phenomena. We hope that this chapter gives scholars the direction to find research opportunities and the confidence to pursue them; research opportunities that have the potential to make an important contribution to the entrepreneurship field.
Managing Trade-Offs in Entrepreneurial Theorizing
Authors: Shepherd Dean A. , Patzelt Holger 
Published: January 2023

AbstractWhile several editors and scholars have shared critical insights into the craft of writing a theory paper, there is an essential aspect of publishing a theory paper that is less understood: the process by which expert reviewers and authors engage in the review process, which has a significant influence on theory. We examine critiques and responses to entrepreneurship theorizing to identify three major challenges of entrepreneurship theorizing: (1)the scopeof the entrepreneurship paper’s theorizing being either too narrow or too shallow; (2) the common features of the paper’scontextualization, boundary conditions,andtime considerations; and (3) the“point of view” of the entrepreneurship paper’s perspective—theoretical, philosophical, level, and purpose.This chapter offers a framework that guides (1) entrepreneurship scholars to find a balance to maximize their contributions and (2) reviewers and editors on managing the revise-and-resubmit process to advance the entrepreneurship field.