bluuebunny/crossref_metadata_2025_split huggingface dataset:
The burden of heart failure in cardiac intensive care unit: a prospective 7 years analysis
Authors: Grupper Avishay , Chernomordik Fernando , Herscovici Romana , Mazin Israel , Segev Amitai , Beigel Roy , Matetzky Shlomi 
Published: February 2023

AbstractAimsThe profiles of patients at cardiac intensive care units (CICU) have evolved towards a patient population with an increasing number of co‐morbid medical conditions and acute heart failure (HF). The current study was designed to illustrate the burden of HF patients admitted to CICU, and evaluate patient characteristics, in‐hospital course and outcomes of CICU patients with HF compared with patients with acute coronary syndrome (ACS).Methods and resultsA prospective study including all consecutive patients admitted to the CICU at a tertiary medical centre between 2014 and 2020. The main outcome was a direct comparison between HF and ACS patients in processes of care, resource use, and outcomes during CICU hospitalization. A secondary analysis compared ischaemic versus non‐ischaemic HF aetiology. Adjusted analysis evaluated parameters associated with prolonged hospitalization. The cohort included 7674 patients with a total annual CICU admissions of 1028–1145 patients. HF diagnosis patients represented 13–18% of the annual CICU admissions and were significantly older with higher incidence of multiple co‐morbidities compared with patients with ACS. HF patients also required more intensive therapies and demonstrated higher incidence of acute complications as compared with ACS patients. Length of stay at the CICU was significantly longer among HF patients compared with patients with ACS (either STEMI or NSTEMI) (6.2 ± 4.3 vs. 4.1 ± 2.5 vs. 3.5 ± 2.1, respectively, P < 0.001). HF patients represented a disproportionately higher amount of total CICU patient days during the study period, as the total length of hospitalization of HF patients was 44–56% out of the total cumulative days in CICU of patients with ACS every year. In hospital mortality rates were also significantly higher among patients with HF compared with STEMI or NSTEMI (4.2% vs. 3.1% vs. 0.7%, respectively, P < 0.001). Despite several differences in baseline characteristics between patients with ischaemic versus non‐ischaemic HF, which can be attributed mainly to disease aetiology, hospitalization length and outcomes were similar among the groups regardless of HF aetiology. In multivariable analysis for the risk of prolonged hospitalization in the CICU adjusted to potential significant co‐morbidities associated with poor outcomes, HF was found to be an independent and significant parameter associated with the risk of prolonged hospitalization with an OR of 3.5 (95% CI 2.9–4.1, P < 0.001).ConclusionsPatients with HF in CICU have higher severity of illness with a prolonged and complicated hospital course, all of which can substantially increase the burden on clinical resources.
Quantitative model for predicting the electroosmotic flow in dual‐pole nanochannels
Authors: Khosravikia Mohammad 
Published: February 2023

AbstractDeveloping and assessing nanofluidic systems is time‐consuming and costly owing to the method's novelty; hence, modeling is essential to determine the optimal areas for implementation and to grasp its workings. In this work, we examined the influence of dual‐pole surface and nanopore configuration on ion transfer simultaneously. To achieve this, the two trumpet and cigarette configuration were coated with a dual‐pole soft surface so that the negative charge could be positioned in the nanopore's small aperture. Subsequently, the Poisson–Nernst–Planck and Navier–Stokes equations were simultaneously solved under steady‐state circumstances using varied values physicochemical properties for the soft surface and electrolyte. The pore's selectivity was , and the rectification factor, on the other hand, was , when the overall concentration was very low. When the ion partitioning effect is taken into account, we clearly show that the rectifying variables for the cigarette configuration and the trumpet configuration can reach values of 45 and 49.2, when the charge density and mass concentration were 100 mol/m3 and 1 mM, respectively. By using dual‐pole surfaces, the controllability of nanopores’ rectifying behavior may be modified to produce superior separation performance.
The influence of the development of dunes on the stability of bifurcations in sand‐bed rivers
Authors: Jing Ye , Qin Jie 
Published: February 2023

AbstractChannel bifurcations are common features observed in fluvial landforms from upstream gravel‐bed rivers to downstream deltas. Extensive research has been carried out to study the stability and equilibrium configurations of bifurcations in the last two decades. However, existing studies generally employed oversimplified flow resistance equations, and the influence of the development of bedforms on the stability of bifurcations is rarely explicitly considered. The morphological features of bedforms in sand‐bed rivers vary with flow conditions, which in turn affect flow resistance and sediment transport processes. Such a mutual feedback process is expected to exert a significant influence on the evolution of a bifurcation. A theoretical one‐dimensional (1D) model is built, based on the classical model proposed by Bolla Pittaluga et al. in 2003, to evaluate the influence of the development of dunes on the stability of bifurcations. Results show that the development of dunes enhances the stability of symmetric bifurcations for low Shields stress conditions, whereas it exhibits an opposite effect under the situation of high Shields stress. The response of flow resistance to the perturbations of the Shields stress dominates over the response to the perturbations of the flow depth. In addition, based on the two‐dimensional (2D) model proposed by Redolfi et al. in 2016, this study compared the results of the 1D and 2D models taking into account the development of dunes, and evident differences between the models present at small Shields stresses. Meanwhile, 2D models with or without considering the influence of dunes exhibit different results as well. The results of this study demonstrate that considering the development of dunes is of significance when analysing the stability of bifurcations in sand‐bed rivers.
Secoisolariciresinol diglucoside and anethole ameliorate lipid abnormalities, oxidative injury, hypercholesterolemia, heart, and liver conditions
Authors: Noreen Sana , Rehman Habib‐ur , Tufail Tabussam , Badar Ul Ain Huma , Awuchi Chinaza Godswill 
Published: February 2023

AbstractFennel seeds and flaxseed have been traditionally used against many medical ailments due to their medicinal characteristics. The aim of the study was to investigate the health properties of secoisolariciresinol diglucoside (SDG) and anethole from flaxseed and fennel seeds in rats fed with high‐fat diet. Histopathological changes in the heart and liver were also examined. Sixty rats were divided into two main groups. Group I (10 rats) was used as a negative control group and fed on the basal diet only. Group II (50 rats) was fed a hypercholesterolemic diet but not given any drugs during the trial for 2 weeks. This group was further divided into five subgroups (10 rats each). One of them was fed on the basal diet and used as a positive control group. However, the other four subgroups were fed on basal diets and anethole (20 mg/kg/day, orally), SDG (20 mg/kg/day, orally), a mixture of anethole + SDG (10 + 10 mg/kg/day, orally), and atorvastatin (10 mg/kg/day, orally) for 6 weeks. Compared to control, treatment with a combination of anethole + SDG showed a significant (p ≤ .05) improvement in serum levels of triglyceride (TG) (137.88 ± 1.61 mg/dL), total cholesterol‐(TC) (180.12 ± 8.99 mg/dL), LDL‐C (46.40 ± 6.67 mg/dL), VLDL‐C (11.81 ± 1.07 mg/dL), aspartate aminotransferase (AST) (75.97 ± 6.92 U/L), alanine aminotransferase (ALT) (34.83 ± 2.17 U/L), alkaline phosphatase (ALP) (130.65 ± 1.05 U/L), and malondialdehyde (MDA) (30.12 ± 1.89 mmol/g), and improved activities of catalase (70.99 ± 3.29 U/g) and superoxide dismutase (SOD) (35.13 ± 2.53 U/dL) enzymes while SDG and anethole group had relatively less impact. Atorvastatin also improved serum levels of triglyceride, total cholesterol, LDL‐C, and VLDL‐C significantly and rose serum high‐density lipoprotein cholesterol (HDL‐C) levels considerably meanwhile it had a minor but negative impact on AST, ALT, and ALP, and negligible impact on activities of MDA, CAT, and SOD enzymes compared to the positive control group. The study revealed that combining anethole and SDG may improve dyslipidemia, improve lipid profile, decrease risks of chronic heart diseases, increase HDL‐C, and enhance antioxidant enzymes' activities.
Cucumeropsis mannii seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia
Authors: Aja Patrick M. , Chiadikaobi Chukwu D. , Agu Peter C. , Ale Boniface A. , Ani Onyedika G. , Ekpono Ezebuilo U. , Ogwoni Hilary A. , Awoke Joshua N. , Ogbu Patience N. , Aja Lucy , Nwite Felix E. , Ukachi Oliver U. , Orji Obasi U. , Nweke Peter C. , Egwu Chinedu O. , Ekpono Ejike U. , Ewa Gift O. , Igwenyi Ikechuku O. , Tusubira Deusdedit , Offor Christian E. , Maduagwuna Ekenechukwu K. , Alum Esther U. , Uti Daniel E. , Njoku Amobichukwu , Atoki Victor A. , Awuchi Chinaza G. 
Published: February 2023

AbstractThis study demonstrated the therapeutic potentials of Cucumeropsis mannii seed oil (CMSO) capable of alleviating BPA‐induced dyslipidemia and adipokine dysfunction. In this study, we evaluated the effects of CMSO on adipokine dysfunctions and dyslipidemia in bisphenol‐A (BPA)‐induced male Wistar rats. Six‐week‐old 36 albino rats of 100–200 g weight were assigned randomly to six groups, which received varied doses of BPA and/or CMSO. The administration of BPA and CMSO was done at the same time for 42 days by oral intubation. The adipokine levels and lipid profile were measured in adipose tissue and plasma using standard methods. BPA induced significant (p < .05) increases in triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices in adipose tissue and plasma, as well as a decrease in adiponectin and HDL‐C levels in Group II animals. BPA administration significantly (p < .05) elevated Leptin levels and reduced adiponectin levels. BPA plus CMSO reduced triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices while increasing adiponectin levels and HDL‐C in adipose tissue and plasma (p < .05). The results showed that BPA exposure increased adipose tissue as well as serum levels of the atherogenic index, triglycerides, cholesterol, coronary risk index, LDL‐C, leptin, and body weight with decreased adiponectin levels and HDL‐C. Treatment with CMSO reduced the toxicities caused by BPA in rats by modulating the body weight, adiponectin/leptin levels, and lipid profiles in serum and adipose tissue. This study has shown that CMSO ameliorates BPA‐induced dyslipidemia and adipokine dysfunctions. We suggest for further clinical trial to establish the clinical applications.
Indigenous Sudanese sorghum‐based food: Secondary metabolites and antioxidant activities of traditional Sudanese nonalcoholic beverage Hulu‐mur from two sorghum landraces
Authors: Abdelhalim Tilal Sayed , Abdalla Aisha A. A. , Sir Elkhatim Khitma A. , Othman Mazahir H. , Alkhair Tagwa M. A. Mohammed , Almaiman Salah A. , Osman Magdi A. , Hassan Amro B. 
Published: February 2023

AbstractHulu‐mur is a Sudanese traditional nonalcoholic beverage that is made from sorghum flour. This work determined the secondary metabolites and antioxidant activities of traditional Sudanese nonalcoholic beverage Hulu‐mur from two local sorghum landraces Abjaro and Hegarii. The changes on the total phenolic content (TPC), total flavonoid content (TFC), carotene content, tannins, and antioxidant activity (DPPH, reducing power, and FRAP) were estimated during the preparation of the Hulu‐mur flasks. For both landraces, a significant (p < .05) effect on the phytochemical compound and the antioxidant activity was observed during malting and fermentation of sorghum flour. However, the most increase in the TPC and carotene content was observed, whereas tannin and TFC were decreased in the Hulu‐mur flasks compared with the malted and fermented samples. The antioxidant activity DPPH, TRP, and FRAP was significantly (p < .05) higher in Hulu‐mur flasks than those of raw and processed flour. The partial least squares regression test stated a positive validation score of the Hulu‐mur flasks prepared from the both landraces. In conclusion, Hulu‐mur drink from Abjaro and Hegarii landraces contain high antioxidants compound, which could improve the health‐promoting metabolites in Sorghum‐based food.
Temperature, storage, and natural gas futures prices
Authors: Chen Yanting , Hartley Peter R. , Lan Yihui 
Published: February 2023

AbstractPrevious literature suggests that daily changes in US natural gas (NG) futures prices and their variance can be explained by changes in oil futures prices and volatilities, storage announcements, and temperature shocks. These studies measure temperature shocks using the National Oceanic and Atmospheric Administration definitions of heating degree day (HDD) and cooling degree day (CDD). We show how hourly temperatures can be used to better measure how long as well as how much temperatures depart above and/or below the “comfort level” within a day, the effects of temperature variability within a day, and the effects of thermal inertia. Hourly temperatures also allow us to construct measures of extreme temperatures that better match the timing of release of other market information. Another innovation is that we use more economically relevant weights to convert regional temperature shocks to national averages, and measure expected values of variables via econometric models instead of historical averages. Our results show that the proposed measures of HDD and CDD and temperature changes are important for explaining weekly changes in NG in storage and daily changes in NG futures prices and their variance.
Dysfunction of NG2 glial cells affects neuronal plasticity and behavior
Authors: Timmermann Aline , Tascio Dario , Jabs Ronald , Boehlen Anne , Domingos Catia , Skubal Magdalena , Huang Wenhui , Kirchhoff Frank , Henneberger Christian , Bilkei‐Gorzo Andras , Seifert Gerald , Steinhäuser Christian 
Published: February 2023

AbstractNG2 glia represents a distinct type of macroglial cells in the CNS and is unique among glia because they receive synaptic input from neurons. They are abundantly present in white and gray matter. While the majority of white matter NG2 glia differentiates into oligodendrocytes, the physiological impact of gray matter NG2 glia and their synaptic input are still ill defined. Here, we asked whether dysfunctional NG2 glia affect neuronal signaling and behavior. We generated mice with inducible deletion of the K+ channel Kir4.1 in NG2 glia and performed comparative electrophysiological, immunohistochemical, molecular and behavioral analyses. Kir4.1 was deleted at postnatal day 23–26 (recombination efficiency about 75%) and mice were investigated 3–8 weeks later. Notably, these mice with dysfunctional NG2 glia demonstrated improved spatial memory as revealed by testing new object location recognition while working and social memory remained unaffected. Focussing on the hippocampus, we found that loss of Kir4.1 potentiated synaptic depolarizations of NG2 glia and stimulated the expression of myelin basic protein while proliferation and differentiation of hippocampal NG2 glia remained largely unaffected. Mice with targeted deletion of the K+ channel in NG2 glia showed impaired long‐term potentiation at CA3‐CA1 synapses, which could be fully rescued by extracellular application of a TrkB receptor agonist. Our data demonstrate that proper NG2 glia function is important for normal brain function and behavior.
Efficacy of perineal massage during the second stage of labor for the prevention of perineal injury: A systematic review and meta‐analysis
Authors: Marcos‐Rodríguez Andrea , Leirós‐Rodríguez Raquel , Hernandez‐Lucas Pablo 
Published: February 2023

AbstractBackgroundNumerous interventions to reduce perineal trauma during childbirth have been studied in recent years, including perineal massage.ObjectiveTo determine the efficacy of perineal massage during the second stage of labor to prevent perineal damage.Search StrategySystematic search in PubMed, Pedro, Scopus, Web of Science, ScienceDirect, BioMed, SpringerLink, EBSCOhost, CINAHL, and MEDLINE with the terms Massage, Second labor stage, Obstetric delivery, and Parturition.Selection CriteriaThe articles must have been published in the last 10 years; the perineal massage was administered to the study sample; and the experimental design consisted of randomized controlled trial.Data Collection and AnalysisTables were used to describe both the studies' characteristics and the extracted data. The PEDro and Jadad scales were used to assess the quality of studies.Main ResultsOf the 1172 total results identified, nine were selected. Seven studies were included in the meta‐analysis and indicated a statistically significant decreased number of episiotomies in perineal massage.ConclusionsMassage during the second stage of labor appears to be effective in preventing episiotomies and reducing the duration of the second stage of labor. However, it does not appear to be effective in reducing the incidence and severity of perineal tears.
Hospital case volume and maternal adverse events following abnormal deliveries: Analysis using a Japanese national in‐patient database
Authors: Muramatsu Keiji , Shigemi Daisuke , Honno Katsumi , Matsuoka Masumi , Fujino Yoshihisa , Yasunaga Hideo , Unno Nobuya , Mitsuda Nobuaki , Kimura Tadashi , Matsuda Shinya 
Published: February 2023

AbstractObjectiveTo clarify the relationship between the number of deliveries and maternal outcomes in Japan, considering the declining birth rate and the evidence that hospitals with few deliveries have medical safety issues.MethodsHospitalizations for deliveries were analyzed using the Diagnosis Procedure Combination database from April 2014 to March 2019, after which maternal comorbidities, maternal end‐organ injury, medical treatment during hospitalization, and hemorrhage volume during delivery were compared. Hospitals were divided into four groups based on the number of deliveries per month.ResultsA total of 792 379 women were included in the analysis, among whom 35 152 (4.4%) received blood transfusions, with a median blood loss of 1450 mL during delivery. Regarding complications, pulmonary embolism was significantly more frequent in hospitals with the lowest number of deliveries.ConclusionUsing a Japanese administrative database, this study suggests an association between hospital case volume and the occurrence of preventable complications, such as pulmonary embolisms.
Effect of a follow‐up counseling program on mental health of oocyte donors: A randomized field trial
Authors: Adib Moghaddam Elham , Kazemi Ashraf , Kheirabadi Gholamreza 
Published: February 2023

AbstractObjectiveTo evaluate the effect of a follow‐up counseling program on oocyte donors' mental health.MethodsA randomized controlled field trial conducted on 72 Iranian women who volunteered for oocyte donation. The intervention was designed based on the qualitative section of the study and review of the literature, as face‐to‐face counseling, an Instagram page, an educational pamphlet, and a briefing session for service providers. Mental health was assessed using the DASS‐21 questionnaire in two stages before ovarian stimulation (T1) and ovum pick‐up (T2).ResultsThe scores of depression, anxiety, and stress after ovum pick‐up in the intervention group were significantly lower than in the control group. Besides, after ovum pick‐up, the satisfaction of participation in an assisted reproductive technique (P < 0.001) in the intervention group was significantly higher than the control group, respectively. In the intervention group, the mean scores of depression and stress were lower at T2 compared to T1 (P < 0.001).ConclusionThis study showed that the follow‐up counseling program could influence these oocyte donors' mental health during participation in assisted reproductive techniques. Designing these programs in the cultural context of each country is recommended.Trial RegistrationIranian Registry of Clinical Trials (IRCT20200617047811N1), Date of registration: 07/25/2020, Registry URL: https://www.irct.ir/trial/49196
Longitudinal associations between emotion regulation strategies and subjective well‐being in migrant and non‐migrant adolescents in urban China
Authors: Jiang Liuqing , Yuan Keman , Hart Craig H. , Liang Lichan , Yang Chongming , Wang Zhipin , Bian Yufang 
Published: February 2023

This study examined the long‐term reciprocal impact of two key emotion regulation strategies, cognitive reappraisal and expressive suppression, on the subjective well‐being of migrant and non‐migrant adolescents in urban China. A total of 2397 middle school students from urban China (864 migrant,Mage = 13.05 years,SD = 0.62, 41.7% girls; 1533 non‐migrant,Mage = 13.01 years,SD = 0.47, 50.1% girls) were followed from 2016 to 2017. Data on the two emotion regulation strategies (measured using the Chinese version of the Emotion Regulation Questionnaire) and subjective well‐being (measured using the Subjective Well‐Being Inventory) were collected. Although no differences were found in the use of cognitive reappraisal, migrant adolescents reported greater use of expressive suppression than non‐migrant adolescents. Furthermore, a two‐group cross‐lagged panel analysis showed that cognitive reappraisal positively predicted subjective well‐being among both migrant and non‐migrant adolescents, whereas expressive suppression was positively related to subjective well‐being in only migrant adolescents. Migrant adolescents with higher levels of subjective well‐being jointly used cognitive reappraisal and expressive suppression, while non‐migrant adolescents were prone to only using cognitive reappraisal. These findings indicate that group‐level context influences both the utilisation and functionality of emotion regulation strategies among migrant and non‐migrant adolescents in urban China.
Impact of climate and irrigation practices on hydrological aspects of Bundala wetlands in Sri Lanka
Authors: Kariyawasan Patabendige Kalpana Madushani , Amarasinghe Mala Damayanthi , Ratnayake Ratnayake Mudiyanselage Chula Sena , Dahanayaka Dahanayakage Don Gihan Lakmal 
Published: February 2023

AbstractBundala wetlands are the first to be declared a Ramsar wetland reserve in Sri Lanka. Two wetlands of this complex have transformed from seasonally inundated saline areas into permanent freshwater ecosystems, resulting in spatial and temporal changes that presumably have favoured plant invasions. We hypothesized that climate/rainfall changes and irrigation practices would be the most potential drivers of this change, and the objective of this research is to empirically determine the influence of rainfall and irrigation practices in the catchment on inundation pattern and plant nutrient availability that could potentially change ecology of these wetlands. Monthly rainfall data for the Bundala area (1988–2017) from Sri Lanka's meteorological department were analysed by parametric and nonparametric statistical methods, and a statistically significant change in rainfall was not discernible, confirming climate change is unlikely to be a driver to increase the lagoon water level. Irrigation data analysis revealed that these wetlands receive nearly 1.28 × 107 m3 of irrigation drainage annually from an irrigation scheme in the immediate catchment, which has resulted in decreased salinity, while inundation and plant nutrient content increased, changing the wetlands' ecology and socioeconomic status of the dependent rural communities.