bluuebunny/crossref_metadata_2025_split huggingface dataset:
HELLS inhibits cervical cancer cells ferroptosis by promoting Nrf2 expression
Authors: tie weiwei , ge fenfen 
Published: March 2023

Abstract
Cervical cancer is the leading cause of morbidity and mortality in women throughout the world, However, the underlying mechanism of cervical cancer progression is still unclear. In the current study, we found that lymphoid-specific helicase (HELLS) was significantly increased in cervical cancer. The function of HELLS was assessed by gain- and loss-function experiments. Functionally, the cell viability was assessed by CCK8 and cell proliferation was analyzed by colony formation assay. We found that HELLS overexpression significantly promoted cell viability and colony formation of cervical cancer cell, whereas HELLS inhibition suppressed these effect. Moreover, MDA and ROS induced by ferroptosis inducers erastin were restored by HELLS-OE. Mechanically, we confirm that HELLS promote cervical cancer proliferation by regulating Nrf2-mediated ferroptosis. In conclusion, our data suggest HELLS promote cervical cancer proliferation by inhibiting Nrf2 expression, and HELLS knockdown might be an effective treatment for cervical cancer.
The Relationship between Organizational Justice, Responsibility, and Job Satisfaction among Jordanian Nurses
Authors: Fadel Amena , Khrais Huthaifah , Bani-Hani Manar , Nashwan Abdulqadir J. 
Published: March 2023

AbstractAim: The study aims to examine the relationships between organizational justice, corporate social responsibility, and job satisfaction among nurses in Jordan.Methods: A quantitative, cross-sectional design was utilized the study utilized a descriptive cross-sectional research design. The study was performed in a single hospital site in Jordan. A total of 178 nurses participated in the study. The Organizational Justice Scale, Corporate Social Responsibility Scale, and the Minnesota Satisfaction Questionnaire were used to measure the primary variables. Ethical approval was given by relevant ethical review boards.Results: Nurses had moderate levels of organizational justice, corporate social responsibility, and job satisfaction. Female nurses were found to have significantly higher levels of ethical corporate social responsibility than male nurses (P<0.05). No other significant differences or relationships were found on the levels of organizational justice, corporate social responsibility, and job satisfaction based on sociodemographic characteristics (P>0.05). Organizational justice had a significant, positive relationship with corporate social responsibility (r= 0.50,p= 0.000). Both organizational justice and corporate social responsibility had significant, positive relationships with job satisfaction (r= 0.60,r= 0.74,p< 0.001) consecutively.Conclusion: Healthcare organizations with high levels of organizational justice and corporate social responsibility reflect work environments that are fair, honest, objective, and morally and socially responsible not only to patients who are direct recipients of care but also to the public and wider society. Implementing policies and guidelines that espouse organizational justice and corporate social responsibility can help embed and institutionalize these concepts within healthcare organizations. Future research should be directed towards exploring factors that mediate the levels of job satisfaction, and in turn, how these factors might affect organizational justice and corporate social responsibility.
MIR100HG promoted ferroptosis via regulating the expression of ACSL3 in lung cancer cells
Authors: Liu Yan , Wang Xianwei , Chen Quan , Xu Zhihong , Zhou Shijie , Zhang Hao 
Published: March 2023

Abstract

MIR100HG, a lncRNA residing on chromosome 11, affected the occurrence and prognosis of many cancers. Although previous reports revealed that MIR100HG was down-regulated in lung tumor tissues and prolonged the survival time of lung cancer patients, its detailed mechanism remained elusive. In our study, the mechanism of MIR100HG on ferroptosis in lung cancer cells was investigated. RT-PCR revealed that MIR100HG was upregulated by RSL3. Subsequently, MIR100HG was found to affect intracellular GSH and ROS levels and promote RSL3-induced ferroptosis in lung cancer cells. In vitro experiments, including transcriptomics sequencing, RT-PCR, western blot and RNA immunoprecipitation (RIP), found that MIR100HG was mainly located in the nucleus and negatively regulated the expression of ACSL3 via affecting the association of HuR and the mRNA of ACSL3. Analyzing RNA-sequencing data in TCGA database and measuring their expression levels unveiled that MIR100HG and ACSL3 were differentially expressed between lung cancer and paired-paracancerous tissues. Moreover, KM plotter results indicated that MIR100HG and ACSL3 affected the prognosis of lung cancer patients. Although still needing to be further investigated, our results showed that the MIR100HG-ACSL3 axis regulated ferroptosis in lung cancer cells and affected the occurrence and prognosis of lung cancer for the first time.
Dissecting the role of HOG mitogen-activated protein kinase signaling in the regulation of Yeast Flocculation
Authors: Kumawat Ramesh , Tomar Raghuvir 
Published: March 2023

AbstractThe living organisms are frequently exposed to multiple biotic and abiotic stress forms during their lifetime. Organisms cope with stress conditions by regulating their gene expression programs. In response to different environmental stress conditions, yeast cells activate different tolerance mechanisms. Many of these mechanisms share common signaling pathways. Flocculation of yeast is one of the key mechanisms to survive under unfavorable environmental conditions. The Tup1-Cyc8 corepressor complex is a major regulator of yeast flocculation. In addition, yeast cells also utilize different MAPK pathways to regulate the expression of genes during stress conditions. Here we present the pieces of evidence that the HOG MAPK pathway is involved in the regulation of yeast flocculation phenotype. We observed constitutive activation of the HOG MAPK pathway in flocculating cells. The binding of phosphorylated Hog1 at theFLOgenes promoter increases significantly upon sodium chloride exposure. We found that the treatment of cells with cantharidin reduces the Hog1 phosphorylation, causing a sharp reduction in the expression ofFLOgenes and flocculation phenotype. Similarly, deletion of theHOG1in flocculating cells, resulted in the reduction of flocculation. Altogether our results suggest the involvement of HOG MAPK in the regulation ofFLOgenes and flocculation of yeast.
Poincaré inequalities on Carnot Groups and spectral gap of Schrödinger operators
Authors: Chatzakou Marianna , Federico Serena , Zegarlinski Boguslaw 
Published: March 2023

Abstract
In this work we give a sufficient condition under which the global Poincaré inequality on Carnot groups holds true for a large family of probability measures absolutely continuous with respect to the Lebesgue measure. The density of such probability measure is given in terms of homogeneous quasi-norm on the group. We provide examples to which our condition applies including the most known families of Carnot groups. This, in particular, allows to extend the results in our previous work [16]. A consequence of our result is that the associated Schrödinger operators have a spectral gap.
Discontinuous clogging in gently tapered microchannels reveals a transient Markov process
Authors: Majekodunmi Olukayode , Hashmi Sara 
Published: March 2023

Abstract
Colloidal clogging is typically studied in pores with constrictions arranged in parallel or series. In these systems, clogging statistics are governed by Poisson processes; the time interval between clogging events exhibits an exponential distribution. However, an entirely different phenomenon is observed in a gently tapered pore geometry. Unlike in non-tapered constrictions, rigid particles clogging tapered microchannels form discrete and discontinuous clogs. In a parallelized system of tapered microchannels, we analyze distributions of clog dimensions for different flow conditions. Clog width distributions reveal a lognormal process, arising from concurrent clogging across independent parallel microchannels. Clog lengths, however, which are analogous to growth time, are exponentially distributed. This indicates a Poisson process where events do not occur simultaneously. These two processes are contradictory: clogging events are statistically dependent within each channel while clogs grow simultaneously across independent channels. The coexistence of Poisson and lognormal processes suggests a transient Markov process in which clogs occur both independently of, and dependently on, other clogs. Therefore, discussions of the stochastic character of clogging may require holistic consideration of the quantities used to assess it. This study reveals small adjustments to pore spaces can lead to qualitative differences in clogging dynamics, suggesting the importance of geometry.
Effect of Enterocytozoon hepatopenaei on Richness of Gut Bacterial Community in Exopalaemon carinicauda
Authors: Li Wanying , Hua Songsong , Du Zhengwei , Li Yongchuang , Jiang Haiyi , Yu Miaomiao , Baloch Wazir Ali , Noonari Sumera , Yan Binlun , Gao Huan 
Published: March 2023

Abstract
To investigate the characteristics of the intestinal flora of Exopalaemon carinicaudainfected with Enterocytozoon hepatopenaei (EHP), we analyzed the intestinal flora of the infested individuals by sequencing 16s rRNA genes. In this study, we analyzed the differences in species and abundance of intestinal flora in different EHP load groups (no load group (control group, C), high load group (H) and low load group (L)). The results showed that the intestinal flora diversity in group H was significantly lower than that of shrimp in group C (P < 0.05). UPGMA-based clustering tree and PCoA analysis showed that, unlike group C, bacterial communities clustered together in groups H and L, suggesting that infection with EHP could alter the compositional structure of shrimp gut microbes. By species abundance clustering heat map analysis, most of the dominant bacteria in groups L and C were beneficial bacteria, such as Lactococcus , Ligilactobacillus and Bifidobacterium。In contrast, most of the dominant genus in group H were pathogenic bacteria, such as Pseudomonas , Photobacterium andCandidatus_Hepatincola. By predicting the functions associated with intestinal flora, the genes associated with metabolism were more abundant in group C, metabolism and nervous system in group L, and disease and environmental processing in group H. This study provides an aid for further screening of EHP antagonist bacteria.
Exploring of mechanisms and predicting of potential drugs of the comorbidity between migraine and multiple sclerosis based on bioinformatics analysis of transcriptome data
Authors: Zhang Yingying , Rang Xinming , Wang Xin , An Ning , Hong Xiangxiang , Chai Tengyue , Nie Yingkun , Xu Chaohan , Fu Jin 
Published: March 2023

Abstract
Background: Migraine and multiple sclerosis (MS) are frequent clinical partners, but the mechanisms and treatments of the comorbidity of the two are still unclear. This study aimed to investigate the shared mechanisms and predict potential drugs of migraine and MS with a view to provide new clues and approaches for clinical management.
Methods: So firstly, PRJEB40032 (migraine) from ENA and GSE21942 (MS) from GEO were analyzed for differentially expressed genes (DEGs). And then, gene clusters and hub genes for common DEGs were identified, as well as functional annotation and pathway enrichment analysis were performed for exploring the gene signatures and molecular mechanisms of the comorbidity. Further, hub genes and critical pathways were evaluated by the receiver operating characteristic curves (ROC) and previous studies. Finally, the drugs targeting hub genes and critical pathways were predicted, of which drugs targeting both hub genes and critical pathways were further screened.
Results: 112 DEGs were identified to be related to the comorbidity of migraine and MS, of which 9 hub genes (IL1B,JUN, CXCL8, FOS, ICAM1, MMP9, EGR1,LCN2, MMP8) were of high diagnostic value for the comorbidity. Functional annotation and pathway enrichment analysis showed that inflammatory response regulation and reactive oxygen species metabolism played a major role, and multiple pathways such as IL17 signaling pathway were involved in the comorbidity. 5 hub genes and 17 critical pathways were further evaluated, with predicted 112 and 535 drugs, respectively, including aspirin (non-steroidal anti-inflammatory drugs (NSAIDs)), baclofen (gamma-aminobutyric acid (GABA) receptor agonist), and melatonin (antioxidant). Ultimately, 10 drugs targeting both hub genes and critical pathways were screened, mainly anti-inflammatory drugs, immunological agents and antineoplastic drugs, in which there were three IL-1β inhibitors with high potential research value for the treatments of the comorbidity.
Conclusions: We found that inflammation and oxidative stress were closely related to the comorbidity of migraine and multiple sclerosis. We also predicted some drugs for drawing on from each other and the comorbidity, such as NSAIDs, GABA receptor agonists/analogs andIL-1β inhibitors.
A Study on Hybrid Fiber Reinforced Geopolymer Concrete Short Columns Under Uni- Axial Compression
Authors: N Kashyap A.M. , RAO TANIMKI , RAO NARAPARAJU VENKATA RAMANA 
Published: March 2023

Abstract
The existing literature is rich in plain cement concrete short columns, but it is deficient with respect to geopolymer concrete (GPC) short columns with the incorporation of fibers with hybridization. The current investigation focuses to identify and measure the structural performance and behavior of two grades of GPC viz., normal and high strength grade with and without hybrid fibers. Two types of fibers i.e., steel and polypropylene are utilized to prepare the hybrid fiber reinforced GPC (HFRGPC) ranging from 0–2% in the increments of 0.5% coupled with longitudinal reinforcement. A total of 20 short columns (10 circular and 10 square headed) having a height of 1000 mm and sizes of 150 mm dia. and 150x150 mm respectively are prepared and tested for uni axial compression loading. The study results indicated that the circular GPC short columns possess better structural performance at ultimate load in terms of ductility ratio than those of square headed GPC specimens with and without fibers. The significant impacts of fiber volume fraction are investigated and reported. The experimental results of the of short columns showed a good agreement with the theoretical results.
Bias reduction of high return levels for extreme hazard modelling
Authors: Wang Chi-Hsiang 
Published: March 2023

Abstract
Many existing extremal data span only a few decades, often resulting in large bias and uncertainty in the estimated shape parameter of the extreme hazard model. This in turn leads to unreliable predicted extreme values at high average recurrence intervals (ARI’s). This paper illustrates a statistical method that provides a mechanism to obtain a hazard model that produces return levels at high ARI’s with reduced bias. The method makes use of the maximum recorded values of extremal data independently recorded from a number of observational sites. The logarithmically transformed probability of the maximum recorded value at a site is shown to follow the Gumbel (Type I extreme-value) distribution, therefore multiple, say m, sites provide a sample of size m transformed probabilities of extreme values, each from a distinct site. The sample can be treated as being drawn from a Gumbel distribution, irrespective of the underlying hazard-generating mechanisms or the statistical hazard models. The method is demonstrated by an analysis of the extreme wind gust data collected from automatic weather stations in South Australia. The results are compared to the specifications in the Australian standard AS/NZS 1170.2:2021 and indicates that the standard may have overestimated the wind gust hazard, hence the specified design wind speeds may fall on the conservative side for South Australia.
Engineering Ga2O3 phases with MIST-CVD for Gas Sensing Applications
Authors: Kumar Ashish , Praneeth Marem Padma , Al-Shidaifat AlaaDdin , Song Hanjung , Chakrabartty Shubhro Shubhro 
Published: March 2023

Abstract
With the utilization of UV-C radiation sterilizers on the ascension in the wake of the recent pandemic, it has become imperative to have health safety systems in place to curb the ill effects on humans. This requires detection systems with felicitous spectral replication to the “invisible to the unclad eye” radiation leaks with utmost sensitivity and swiftness. Gallium Oxide (Ga2O3), a semiconductor, has gained a lot of attention among researchers due to its ultra-wideband gap (4.9eV) and high critical field with a value of 8 MV/cm. It is Transparent Conductive Oxide (TCO). Ga2O3 has five different atomic structures of Ga2O3, namely, the monoclinic (β-Ga2O3), rhombohedral (α), defective spinel (γ), cubic (δ), and orthorhombic (ε) structures. Of these, the β-polymorph is selected because of band gap energy (Eg ≈ 4.7–4.9 eV), it is highly stable in thermal and chemical properties. In this context, the present article demonstrates the best and most suitable technique for the deposition of β-Ga2O3 (Gallium Oxide). This work demonstrates the layer deposition of β-Ga2O3 (Gallium Oxide) thin-film with MIST-CVD (Chemical Vapor Deposition) and optimization of the deposited layer to the extent of using different techniques and analyzing different plots. This deposited layer on a substrate is used for applications of gas sensors or Ultraviolet-Photodetectors (UV-PDs. This article has also demonstrated the successful application of optimized thin film for gas sensing.
Skip (Insertion) Sort, Skip List Based New and Very Efficient Sorting Algorithm
Authors: AKSU Mustafa 
Published: March 2023

Abstract
The aim of this paper is to propose a new sorting algorithm based on skip list. The proposed sorting algorithm has similar/same logic with skip list, due to this case, it was called as SkipSort algorithm. While sorting data, each element is located in its position in a pyramidal way and this position is the required position of element in the sorted array. The locating time of each element is O(N), when there are N elements in unsorted set. Thus, the time complexity of a set of size N will be O(NlgN). The proposed algorithm was applied to a randomly generated set, and the obtained results are superior to the results of sorting algorithms HeapSort, MergeSort, etc. The same case is also valid for sorted set or sorted in descending order set. The performance of the proposed algorithm in sorted or sorted in descending order is better than performance of random case approximately 1.5-2 times.
Early antibiotic de-escalation and discontinuation in Patients with Febrile Neutropenia after Cellular Therapy: A Single Center Prospective Unblinded Randomized Trial
Authors: Ram Ron , Amit Odelia , Adler Amos , On Yael Bar , Beyar-Katz Ofrat , Avivi Irit , Shasha David , Ami Ronen Ben 
Published: March 2023

Abstract
Background - The optimal duration and spectrum of empiric antimicrobial therapy of febrile neutropenia in patients after cellular therapy is unclear. Early de-escalation has been suggested by several groups, however studies exclusively focusing on this group of patients are lacking.
Methods – we performed a randomized controlled study to evaluate the safety and non-inferiority in terms of infectious and transplantation-associated outcomes in patients after cellular therapy with febrile neutropenia who received either standard broad spectrum antibiotic treatment until recovery of neutropenia (control group) versus early de-escalation and discontinuation (EDD) antibiotic strategy.
Results – we randomized 110 patients (control group, n = 51, EDD group, n = 59). The fraction of antibiotic-free neutropenia days was higher for patients in the EDD group compared to control group (median [IQR], 0.8 [0.62–0.86] versus 0.51 [0.17–0.86], respectively, p = .016). This was true for both per-protocol population and for the allogeneic HCT, autologous HCT, and anti-CD19 CAR-T subgroups. Antibiotic success rate, breakthrough fever, death within 30 days, and other common cellular therapy-related toxicities were all similar between the 2 groups.
Conclusions – An EDD antibiotic strategy in patients after cellular therapy was safe and associated with a substantial reduction in broad-spectrum antibiotic utilization without compromising cellular therapy outcomes.
Health economic evaluation of forced orthodontic extrusion of extensively damaged teeth: Up to 6-year results from a clinical study
Authors: Bruhnke Maria , Naumann Michael , Böse Mats Wernfried Heinrich , Beuer Florian , Schwendicke Falk 
Published: March 2023

Abstract
Objectives

Clinical data on retaining extensively damaged teeth using forced orthodontic extrusion followed by restorative rehabilitation are scarce, and economic evaluations basically absent. Based on a clinical study we performed a health economic evaluation of this treatment approach.

Materials and Methods

In a convenience sample of individuals recruited from routine care, extensively damaged teeth were orthodontically extruded prior to restoration. Patients were followed up for up to 6 years. Our health outcome was tooth retention time. Direct medical, non-medical and indirect initial and follow-up costs were estimated using the private payer’s perspective in German healthcare. Association of initial direct medical treatment costs and cofounding variables was analyzed using Generalized Linear Models.

Results

A total of 35 teeth in 30 patients were followed over a mean ± SD of 49 ± 19 months. Five teeth (14%) dropped out during that period. Median initial costs were 1941€ (range: 1284–4392€), median costs for follow-up appointments were 215€ (range: 0–5812€) and median total costs were 2284€ (range: 1453 to 7109€). Tooth survival was 46 ± 20 months. Three teeth had to be extracted and in three patients we observed orthodontic relapse. Endodontic re-treatment and placement of a post had a significant impact on total costs.

Conclusions

Within the limitations of this clinical study, total treatment costs for forced orthodontic extrusion and subsequent restoration of extensively damaged teeth were considerable. Costs were by large generated initially; endodontic and post-endodontic therapies were main drivers. Costs for retreatments due to complications were limited, as only few complications arose.

Clinical Relevance:

The restoration of extensively damaged teeth after forced orthodontic extrusion comes with considerable initial treatment costs, but low follow-up costs. Overall and over the observational period and within German healthcare, costs are below those for tooth replacement using implant-supported crowns.
The study was registered at the German Clinical Trials Register (DRKS registration number: DRK S00026697).
Space-time multibody dynamics
Authors: Hesch C. , Glas S. , Schuß S. 
Published: March 2023

Abstract
In this contribution we apply space-time formulation on constrained multibody dynamics. In particular, we discretize directly Hamilton’s principle using appropriate space-time approximation spaces for the variational problem. Moreover, we make use of a rotationless formulation for the rigid bodies and thus, we have to define appropriate approximation spaces in for the Lagrange multipliers as well. Moreover, we make use of Livens’ principle, introducing independent quantities for the position, velocity and momentum, where the latter can be considered as Lagrange multipliers and apply this concept to the space-time rigid body formulation. Finally, we demonstrate the convergence of the different approaches and the superiority in terms of computational effort and thus, total energy consumption of dynamical simulations.