bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skrining Novel Prebiotik Selective Fermentation Initiator (SFI) Untuk Bakteri Probiotik Elektrogenik Kulit
Authors: Adi Prakoso , Mulyani Rizka , Jackson Yang John 
Published: July 2023

The ability of electrogenic bacteria to generate electricity has been widely reported. In some cases of bacteria, the electricity production comes from the bacterial fermentation process of SFI compounds by these bacteria. Later, the resulted electrons are transferred out from inside to extracellular recipient molecules. Among of these studies has shown the ability of gram-positive bacteria S. epidermidis ATCC 12228 in terms of SFI compounds utilization to increase bacterial electron production and its application in the medical field. Based on these studies, the discovery of new SFI compounds becomes interesting to be explored. In this study, a new SFI compound was screened from 24 different compounds. The screen was initiated by testing the ability of these compounds to increase the fermentation activity of S. epidermidis ATCC 12228 in a 96-well plate. Determination of SFI compound was carried out by checking the exclusivity of the compound to increase the fermentation activity of S. epidermidis ATCC 12228. The selected SFI compound was then tested for cytotoxicity against this bacterium and its ability to increase the electron production of S. epidermidis ATCC 12228 using a microbial fuel cell (MCF). This study was successfully demonstrated the non-toxic properties of p-coumaric acid, also the ability of this compound to increase the fermentation activity and electron production of S. epidermidis ATCC 12228. This research is expected to be the first step to find another novel SFI compounds that will be useful in certain fields in the future.
Application of Pocket Media Letters Against Fine Language And Motor Ability In Early Childhood
Authors: Afnita Juli , Putro Khamim Zarkasih , Naimah Naimah , Rohinah Rohinah 
Published: July 2023

<span> The purpose of this study was to describe the application of letter pocket media to the language skills and fine motor skills of children at the build Peureulak State Kindergarten. This research is a descriptive qualitative type with data collection techniques of observation, interviews and documentation. Researchers made observations at the build Peureulak State Kindergarten with the research subjects there were 10 children aged 5-6 years and 6 teachers at the Peureulak Pembina State Kindergarten. The results showed that pocket letter media could improve children's language skills and fine motor skills.</span>
Evaluation of Humeral Shaft Fracture Outcomes by Treatment Method
Authors: Beyer Julia , Rao Brian , Liu Jiayong , Skie Martin 
Published: July 2023

Background:
The purpose of this systematic review and meta-analysis was to evaluate various outcomes of humeral shaft fractures treated with different treatment methods, which included functional bracing, open reduction and internal fixation, intramedullary nailing, and locked compression plate.

Methods:
A systematic review was performed using research databases including PubMed, EMBASE, and Google Scholar. Keywords relating to treatment of humeral shaft fractures were used, and comparison studies that reported patient characteristics and outcomes, including nonunion, malunion, function scores, and complications, were included. One hundred fourteen records were screened, with 18 studies ultimately included in the meta-analysis. Treatment groups were consolidated into brace or surgery and then further categorized into subgroups based on surgical technique used. Postoperative events, complications, and functional scores were compared among the treatment groups. Statistical analysis for this study was conducted using Review Manager 5.3, with a standard p-value of ≤0.05 for statistical significance.

Results:
Eighteen studies were included in this review with a total of 706 patients. Z-tests showed that risks of revision, nonunion, and malunion were higher in the brace treatment group compared with the surgical treatment group (p < 0.0001, <0.0001, 0.004, respectively). Risk of infection was expectedly higher in the surgical group compared with the brace group (p = 0.04). Radial nerve injury rates were also higher in the unspecified surgical group compared with the brace group (p = 0.01). In the surgical group, the mean Constant shoulder score was also significantly higher than that in the brace group (p = 0.004). When comparing the nail and plate groups, Z-tests revealed higher risks of delayed unions and other complications in the nail group (p = 0.04 and 0.001, respectively) but higher risk of infection in the plate group (p = 0.05).

Conclusion:
The conservative treatment of humeral shaft fractures with functional braces may be associated with a lower incidence of infection and nerve injury when compared with operative treatment methods. However, nonoperative treatment may also come with higher risks of revision, nonunion, and malunion than the many available surgical modalities. Operative management with either intramedullary nail or plate has shown to be a reliable method of management with reasonable outcomes for humeral shaft fractures. While the nail group had higher risk of delayed unions and other complications, the plate group had higher risk of infections. Both nail and plate surgical treatments have shown to result in high union rates and should be considered by the surgeon on a case-by-case basis when treating humeral shaft fractures.

Level of Evidence:

Level I. See Instructions for Authors for a complete description of levels of evidence.
Strategi Penanganan dan Percepatan Penurunan Stunting di Jawa Timur
Authors: Mukodi Mukodi , Rahmawati Deti 
Published: July 2023

Tujuan Penelitian adalah untuk; (1) mendeskripsikan dan menganalisis penurunan stunting di Jawa Timur; (2) memberikan rekomendasi bagaimana strategi penurunan stunting di Jawa Timur, khususnya di Kabupaten Pacitan, Kabupaten Pamekasan dan Kabupaten Malang.
Metode/Pendekatan yang digunakan dalam penelitian ini adalah kualitatif deskriptif dengan metode atau pendekatan studi kasus (case study). Metode pengumpulan data pada studi kasus ini menggunakan tiga prinsip sebagaimana yang disarankan oleh Yin, yakni: (1) menggunakan multi sumber bukti; (2) menciptakan data dasar studi; (3) memelihara rangkaian bukti.
Hasil Penelitian menunjukkan bahwa percepatan penurunan stunting di Provinsi Jawa Timur secara reflektif dapat dilihat di tiga Kabupaten, yakni; Kabupaten Pacitan, Kabupaten Pamekasan dan Kabupaten Malang telah berjalan secara baik dan sistemik. Ketiga kabupaten tersebut sebagai sempel dari wilayah di Jawa Timur telah melakukan penanganan stunting dengan melaksanakan aksi konvergensi, yakni pendekatan penyampaian intervensi yang dilakukan secara terkoordinir, terintegrasi, dan bersama-sama untuk mencegah stunting.
Temuan Penting dalam riset ini adalah terdapat dua intervensi gizi spesifik yang harus dilakukan dalam penanganan kasus stunting; pertama: intervensi spesifik, dan kedua: intervensi gizi sensitive. Intevensi gizi spesifik berprioritas pada: (a) ibu hamil, (b) ibu menyusui, (c) anak-anak 24-59 bulan, (d) remaja dan wanita usia subur. Sementara itu, intervensi gizi sensitive berprioritas pada: (a) peningkatan penyediaan air minum dan sanitasi, (b) peningkatan akses dan kualitas pelayanann gizi serta kesehatan, (c) peningkatan kesadaran, komitmen, dan praktik pengasuhan; (d) gizi ibu dan anak, serta peningkatan akses pangan bergizi.
Simpulan penelitian ini adalah aksi konvergensi yang dilakukan secara Tersistem, Sistemik, dan Massif (TSM/) di tiga kabupaten, yakni Kabupaten Pacitan, Kabupaten Pamekasan dan Kabupaten Malang telah terbukti menekan dan meminimalisir potensi stunting dan bisa dijadikan contoh nyata cara penanganan stunting di wilayah Jawa Timur.
Pore Structure and Fractal Characteristics of Mixed Siliciclastic-Carbonate Rocks from the Yingxi Area, Southwest Qaidam Basin, China
Authors: Zhang Xinlei , Gao Zhiqian , Maselli Vittorio , Fan Tailiang 
Published: July 2023

Summary
Evaluating reservoir properties at the pore scale is vital to better estimate hydrocarbon reserves and plan field development. The lacustrine mixed siliciclastic-carbonate deposits of the Upper Paleogene Xiaganchaigou Formation in the west Yingxiongling area form one of the most important hydrocarbon reservoirs in the southwestern Qaidam Basin (China). In this study, we analyzed well samples with X-ray diffraction (XRD), nuclear magnetic resonance (NMR), and mercury injection capillary pressure (MICP) data in integration with scanning electron microscopy (SEM) images to decipher the mineral composition and pore structure characteristics of the Xiaganchaigou Formation. We also calculate the fractal dimensions using MICP, NMR T2 spectrum, and SEM images based on fractal theory models. The results indicate that the mixed siliciclastic-carbonate samples of the upper section of the Xiaganchaigou Formation are mainly formed by dolomite and clay minerals with low siliceous and calcite content. Porosity is relatively low (2.01−9.83%) and positively correlated with dolomite content, thus indicating that the dolomite intercrystalline pores formed by infiltration and reflux dolomitization control the reservoir characteristics. The size of dolomite intercrystalline pores varies between several and hundreds of nanometers. The porosity has a poor correlation with permeability, which indicates that the pores are mostly primary, which lack the transformation of late dissolution. Three types of mixed siliciclastic-carbonate reservoirs are identified according to pore size distribution (&lt;20 nm, 20−300 nm and multiple distribution), calculated using the NMR T2 spectrum. Fractal curves calculated by combining the MICP and NMR data are characterized by multisegments. The number of segments depends on the degree of heterogeneity of pore structure: two segment for high heterogeneity and three segment for low heterogeneity, also indicating a multifractal feature in mixed rock reservoirs. There is a negative correlation trend between porosity and fractal dimensions, and larger pores often have larger fractal dimensions. These results show that MICP-based fractal values are higher than those of NMR-based, which result from unconnected pores that the MICP is unable to reach. Fractal dimensions obtained from SEM have a small and narrow distribution range and are negatively correlated with the number of pores with smaller sizes. In essence, this study shows that the fractal dimension can be a concise index to evaluate the heterogeneity of lacustrine mixed siliciclastic-carbonate reservoirs, which can serve as an important reference for hydrocarbon development plans.
Detection of Iron Disulfide Materials in Geological Porous Media Using Spectral Induced Polarization Method
Authors: Badhafere D. , Kirmizakis P. , Oshaish A. , El-Husseiny A. , Mahmoud M. , Ntarlagiannis D. , Soupios P. 
Published: July 2023

Summary
Iron sulfide (FeS) scale is a known problem that can significantly impact oil and gas (O&G) production. However, current monitoring methods cannot detect the problem at early stages, not until it is too late for any meaningful remedial action. Spectral induced polarization (SIP) is an established geophysical method increasingly used in near-surface environmental applications. The unique characteristics of the SIP method, mainly the sensitivity to both bulk and interfacial properties of the medium, allow for the potential use as a characterization and monitoring tool. SIP is particularly sensitive to metallic targets, such as FeS, with direct implications for the detection, characterization, and quantification of FeS scale. In a column setup, various concentrations of pyrite (FeS2), a common form of FeS scale, within calcite were tested to examine the SIP sensitivity and establish qualitative and quantitative relationships between SIP signals and FeS2 properties. The concentration of FeS2 in the samples directly impacts the SIP signals; the higher the concentration, the higher the magnitude of SIP parameters. Specifically, the SIP method detected the FeS2 presence as low as 0.25% in the bulk volume of the tested sample. This study supports the potential use of SIP as a detection method of FeS2 presence. Furthermore, it paves the way for upcoming studies utilizing SIP as a reliable and robust FeS scale characterization and monitoring method.
Protocol for a scoping review study on learning plan use in undergraduate medical education
Authors: Romanova Anna , Touchie Claire , Humphrey-Murto Susan , Ruller Sydney , Cole Victoria 
Published: July 2023

Abstract
Background
The current paradigm of competency-based medical education and learner-centredness requires learners to take an active role in their training. However, deliberate and planned continual assessment and performance improvement is hindered by the fragmented nature of many medical training programs. Attempts to bridge this continuity gap between supervision and feedback through learner handover have been controversial. Learning plans are an alternate educational tool that help trainees identify their learning needs and facilitate longitudinal assessment by providing supervisors with a roadmap of their goals. Informed by self-regulated learning theory, learning plans may be the answer to track trainees’ progress along their learning trajectory. The purpose of this study is to summarize the literature regarding learning plan use specifically in undergraduate medical education and explore the student’s role in all stages of learning plan development and implementation.
Methods
Following Arksey and O’Malley’s framework, a scoping review will be conducted to explore the use of learning plans in undergraduate medical education. Literature searches will be conducted using multiple databases by a librarian with expertise in scoping reviews. Through an iterative process, inclusion and exclusion criteria will be developed and a data extraction form refined. Data will be analysed using quantitative and qualitative content analyses.
Discussion
By summarizing the literature on learning plan use in undergraduate medical education, this study aims to better understand how to support self-regulated learning in undergraduate medical education. Results from this project will inform future scholarly work in competency-based medical education at the undergraduate level and have implications for improving feedback and supporting learners at all levels of competence.
Scoping review registration
Submitted to Open Science Framework on Oct 17, 2022 (osf.io/wvzbx).
Real-life impacts of olipudase alfa: The experience of patients and families taking an enzyme replace therapy for acid sphingomyelinase deficiency
Authors: Raebel Eva M , Wiseman Samantha , Donnelly Conan Brian , Mathieson Toni , Poutney Jackson , Crowe Joslyn , Hopkin Justin 
Published: July 2023

Abstract

Background:
Acid Sphingomyelinase Deficiency (ASMD) is an ultra-rare autosomal recessive lysosomal storage disorder characterized by intracellular lipid accumulation because of the reduced function of acid sphingomyelinase. Olipudase alfa, an enzyme replacement therapy, was recently approved in several countries for the treatment of the non-neurologic manifestations of ASMD. Studies demonstrate improvement in organomegaly, pulmonary function and lipid profiles with olipudase alfa, yet little is known about its impact on quality of life (QoL) for patients and caregivers. The purpose of this study is to better understand the real-life impact of ASMD on patients and caregivers and assess how olipudase alfa impacts QoL for pediatric patients and their caregivers.
Methods:
Parents of pediatric patients (≤ 18 years of age) with a confirmed diagnosis of ASMD that received olipudase alfa for at least 12 months were recruited in early 2022 through national patient organizations to participate in a global online questionnaire followed by semi-structured interviews. Ten parents of patients with ASMD who utilized olipudase alfa as an experimental therapy for pediatric patients participated in the study. Quantitative analysis of the results was undertaken and interview transcripts were analyzed using an inductive thematic approach.
Results:
Five themes emerged from analysis: (1) ASMD is a systemic disease with a wide array of manifestations that significantly impact QoL. (2) Olipudase alfa was associated with improvements in all non-neurologic manifestations of ASMD. (3) Participants perceived the risk associated with olipudase alfa to be low and the benefits to greatly outweigh any risk or burden. (4) Participants reported an unmet need to treat the neurologic manifestations of the disease despite the benefits of olipudase alfa in the management of non-neurological symptoms. (5) Participants felt all patients with ASMD need access to olipudase alfa based on the life-changing experience they perceived.
Conclusions:
These findings highlight the sustained positive impact olipudase alfa had in many domains that are deemed important to patients and families living with ASMD and outline the significant unmet need for patients and families living with ASMD.
Leaf phenotypic plasticity and integration balance plant adaptation to water table decline: a mesocosm experiment
Authors: Yang Jun , Gao Yongheng , Zhao Chuan , Chen Huai 
Published: July 2023

Abstract
Functional trait-based approaches have been widely used to explore the relationship between plants and their surroundings. Yet, whether phenotypic plasticity and phenotypic integration are differently functional coordination to enhance plant adaptation to declining water levels is still lacking in empirical knowledge. We conducted a mesocosm experiment in an alpine wetland with two dominant plants, Carex muliensis (hygrophytes) and Pedicularis longiflora var. tubiformis (mesophytes), exposed to four water table gradients (WT10, WT0, WT-20 and WT-50, representing the water table at 10 cm, 0 cm, -20 cm and -50 cm from the surface). We measured leaf traits related to resource use strategies, and the relationship between leaf phenotypic plasticity and integration. We found that hygrophytes shifted their leaf traits towards resource-conserving strategies, such as increasing leaf thickness and decreasing leaf area and specific leaf area, under water table decline. In contrast, mesophytes shifted their leaf traits towards resource-acquisition strategies, enhancing their competitiveness and fitness at low water levels. We also found a negative correlation between leaf phenotypic plasticity and integration in both plant species, suggesting a trade-off between them. which was attributed to the fact that wetland plants may prioritize traits that reduce water loss (e.g. larger leaf thickness), resulting in lower integration with other traits (photosynthetic and nutrient use related traits). We conclude that, water table decline alters plant leaf resource use strategies and that the balance between leaf phenotypic plasticity and integration contributes to plant adaptation to water table decline. This study improves our understanding of the role of leaf phenotypic plasticity and integration in plant adaptation in the context of declining water levels in wetlands will help predict the future structure and composition of alpine wetland ecosystems.
GGDP Calculation and Application based on Shadow Prices
Authors: Zou Bin , Song Yiliang , An Hongjun , Li Youlin 
Published: July 2023

Abstract
As global climate and environmental issues continue to increase, Green Gross Domestic Product (GGDP)
has become a more suitable indicator of economic health and development than Gross Domestic Product
(GDP). This paper proposes a new climate-environment cost-based GGDP model in macro form, using
shadow price that is more economically sound than existing GGDP models. We also introduce a new
method called relation chain analysis to export the GGDP model to micro form. Our mathematical
analysis predicts a positive impact of using our model on the global economy and climate.
Attributes of errors, facilitators, and barriers related to rate control of IV medications: A scoping review
Authors: Park Jeongok , You Sang Bin , Ryu Gi Wook , Kim Youngkyung 
Published: July 2023

Abstract
Background
Intravenous (IV) medication is commonly administered and closely associated with patient safety. Although nurses dedicate considerable time and effort to rate control of IV medications, many medication errors have been linked to the wrong rate of IV medication. Further, there is a lack of comprehensive studies examining the literature on rate control of IV medications. This study aimed to identify the attributes of errors, facilitators, and barriers related to rate control of IV medications by summarizing and synthesizing the existing literature.
Methods
This scoping review was conducted using the framework proposed by Arksey and O'Malley and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Scoping Review extension. Overall, four databases— PubMed, Web of Science, EMBASE, and CINAHL—were employed to search for studies published in English before January 2023. We also manually searched reference lists, related journals, and Google Scholar.
Results
A total of 1,211 studies were retrieved from the database searches and 23 studies were identified from manual searches and Google Scholar searches, after which 22 studies were selected for the analysis. Among the nine experimental studies, two interventions were effective in decreasing errors related to rate control of IV medications. One of them was prospective, continuous incident reporting followed by the implementation of prevention strategies, and the other encompassed six interventions to mitigate interruptions in medication verification and administration. Facilitators and barriers related to rate control of IV medications were classified as human, design, and system-related contributing factors. The sub-categories of human factors were classified as knowledge deficit, performance deficit, and incorrect dosage or infusion rate. The sub-category of design factor was device. The system-related contributing factors were classified as frequent interruptions and distractions, training, assignment or placement of healthcare providers or inexperienced personnel, policies and procedures, and communication systems between healthcare practitioners.
Conclusions
Further research is needed to develop effective interventions to improve IV rate control. Considering the rapid growth of technology in medical settings, interventions and policy changes regarding education and the work environment are necessary.