bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal trends in lipid profiles during pregnancy: Association with gestational diabetes mellitus and longitudinal trends in insulin indices
Authors: Shen Lixia , Wang Dongyu , Huang Yihong , Ye Lisha , Zhu Caixia , Zhang Shaofeng , Cai Shiqin , Wang Zilian , Chen Haitian 
Published: January 2023

ObjectiveTo investigate the correlation of trends in lipid profiles from first to second trimester with trends in insulin indices and gestational diabetes mellitus (GDM).MethodsSecondary analysis of an ongoing prospective cohort study was conducted on 1234 pregnant women in a single center. Lipid profiles, glucose metabolism and insulin indices were collected in the first and second trimesters. Trends in lipid profiles were divided into four subgroups: low-to-low, high-to-high, high-to-low and low-to-high group. Insulin indices including homeostasis model assessment of insulin resistance and quantitative insulin sensitivity check index were calculated to evaluate insulin resistance (IR). Trends in insulin indices were described as: no IR, persistent IR, first-trimester IR alone and second-trimester IR alone. Pearson correlation analysis and multivariate logistic regression were performed to assess the associations of lipid profiles subgroups with insulin indices and GDM.ResultsFirst- and second-trimester total cholesterol (TC), triglycerides (TG) and high-density lipoprotein cholesterol were strongly correlated to first- and second-trimester insulin indices. Only TG had a sustained correlation with glucose metabolism indices. High-to-high low-density lipoprotein cholesterol (LDL-c) was an independent risk factor for GDM. High-to-high TG and high-to-low TG groups were independent risk factors for persistent IR. High-to-high TG and low-to-high TG groups were independent risk factors for second-trimester IR alone.ConclusionTG has a sustained correlation with insulin indices and glucose metabolism indices. Persistently high TG is an independent risk factor for persistent IR and second-trimester IR alone. Regardless of whether pregnant women have first-trimester IR, lower TG levels help reduce the risk for persistent IR or subsequent development of IR. These results highlight the benefit of lowering TG levels in early and middle pregnancy to prevent the development of IR.
The clinical outcomes of imaging modalities for surgical management Cushing’s disease – A systematic review and meta-analysis
Authors: Koh Chan Hee , Khan Danyal Z. , Digpal Ronneil , Layard Horsfall Hugo , Ali Ahmad M. S. , Baldeweg Stephanie E. , Bouloux Pierre-Marc , Dorward Neil L. , Drake William M. , Evanson Jane , Grieve Joan , Stoyanov Danail , Korbonits Márta , Marcus Hani J. 
Published: January 2023

IntroductionCushing’s disease presents major diagnostic and management challenges. Although numerous preoperative and intraoperative imaging modalities have been deployed, it is unclear whether these investigations have improved surgical outcomes. Our objective was to investigate whether advances in imaging improved outcomes for Cushing’s disease.MethodsSearches of PubMed and EMBASE were conducted. Studies reporting on imaging modalities and clinical outcomes after surgical management of Cushing’s disease were included. Multilevel multivariable meta-regressions identified predictors of outcomes, adjusting for confounders and heterogeneity prior to investigating the effects of imaging.Results166 non-controlled single-arm studies were included, comprising 13181 patients over 44 years.The overall remission rate was 77.0% [CI: 74.9%-79.0%]. Cavernous sinus invasion (OR: 0.21 [CI: 0.07-0.66]; p=0.010), radiologically undetectable lesions (OR: 0.50 [CI: 0.37–0.69]; p&lt;0.0001), previous surgery (OR=0.48 [CI: 0.28–0.81]; p=0.008), and lesions ≥10mm (OR: 0.63 [CI: 0.35–1.14]; p=0.12) were associated with lower remission. Less stringent thresholds for remission was associated with higher reported remission (OR: 1.37 [CI: 1.1–1.72]; p=0.007). After adjusting for this heterogeneity, no imaging modality showed significant differences in remission compared to standard preoperative MRI.The overall recurrence rate was 14.5% [CI: 12.1%-17.1%]. Lesion ≥10mm was associated with greater recurrence (OR: 1.83 [CI: 1.13–2.96]; p=0.015), as was greater duration of follow-up (OR: 1.53 (CI: 1.17–2.01); p=0.002). No imaging modality was associated with significant differences in recurrence.Despite significant improvements in detection rates over four decades, there were no significant changes in the reported remission or recurrence rates.ConclusionA lack of controlled comparative studies makes it difficult to draw definitive conclusions. Within this limitation, the results suggest that despite improvements in radiological detection rates of Cushing’s disease over the last four decades, there were no changes in clinical outcomes. Advances in imaging alone may be insufficient to improve surgical outcomes.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42020187751.
Performance optimization and kinetic analysis of HNO3 coupled with microwave rapidly modified coconut shell activated carbon for VOCs adsorption
Authors: Rong Xing , Cao Qing , Gao Yan , Du Xin , Dou Huawei , Yan Min , Li Shijie , Wang Qian , Zhang Zhanchao , Chen Baoming 
Published: January 2023

As a typical carbon-based material, activated carbon (AC) has satisfied adsorption performance and is of great significance in the field of volatile organic compounds (VOCs) pollutants removal. In order to further reveal the optimization mechanism of AC adsorption performance, coconut shell-based AC was selected as the research object, and different concentrations of HNO3 coupled with microwave were used for rapid modification and activation. The characteristic changes of pore structure and surface chemical of AC before and after rapid modification were analyzed, and the performance changes of VOCs absorption were discussed from the perspective of reaction kinetics. The pore structure and surface chemical properties of before and after modification were analyzed by X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmeta-Teller (BET) analysis, Fourier Transform Infrared Spectroscopy (FTIR), and Boehm titration. The results showed that HNO3 coupled with microwave could significantly eliminate impurities in the pores of AC. After impregnation in HNO3 at a concentration of 1.5 mol L−1 and under microwave irradiation of 900 W, the number of micropore on the surface of samples increased slightly. When the impregnation concentration of HNO3 continued to increase, the two adjacent pore structures of the samples merged, which lead to a large decrease in the number of micropore and a corresponding increase in the proportion of mesoporous. Meanwhile, the specific surface area SBET of the modified NAC-6 sample increased to 1,140.40 m2 g−1, and the total acidic oxygen-containing functional groups on the surface increased by 0.459 mmol g−1 compared to that of the unmodified raw carbon. Furthermore, by analyzing the experimental results of formaldehyde adsorption on AC samples, it was concluded that the saturated adsorption capacity of the modified NAC-6 sample was 43% higher than that of the raw carbon. This study provides a more convenient and faster modification method for AC in the field of gas phase pollutants purification, which is helpful to realize the practical engineering application of AC with high efficiency, energy saving and sustainable.
Investigation of the physical-mechanical properties and durability of high-strength concrete with recycled PET as a partial replacement for fine aggregates
Authors: Qaidi Shaker , Al-Kamaki Yaman , Hakeem Ibrahim , Dulaimi Anmar F. , Özkılıç Yasin , Sabri Mohanad , Sergeev Vitaly 
Published: January 2023

In this study, PET plastic waste, which is a type of polymer commonly used in the manufacture of plastic bottles, has been incorporated into concrete by partially replacing the natural fine aggregate. An experimental study was conducted by casting and testing 90 concrete cylinders and 54 concrete cubes. A concrete mixture was designed in which the natural fine aggregate was substituted partially with PET plastic waste (PW) at a ratio of 0%, 25%, and 50%, with various w/c ratios of .40, .45, and .55. Physical, mechanical, and durability properties were assessed. The downside of the test results show degradation in each of the following characteristics: slump, compressive strength, splitting tensile strength, ultrasonic pulse velocity, water absorption, and porosity. The degradation of these characteristics increased with the increase in the volume of plastic aggregate (PA) and the w/c ratio. While the positive side of the results showed that with the increase of the PA volume and the w/c ratio, the fresh and dry densities decreased further, and by using 50% PET, the dry density became below 2000 kg/m3. Therefore, it is classified as lightweight concrete. Moreover, the fracture of concrete changed from brittle to more ductile compared to control concrete. Also, the thermal conductivity decreased significantly (11%–47%), and by using 50% of PET, the thermal conductivity became less than .71 W/mK, and accordingly, classified as a bearing insulator.
Study on the mechanical characteristics of a fibre reinforced flexible pipe under radial compression loads
Authors: Sun Zhenwen , Huang Weiping , Lu Hailong , Yan Jun , Yin Yuanchao , Bu Yufeng 
Published: January 2023

Fibre reinforced flexible pipes are subjected to radial compression loads caused by the tensioner during pipe laying, which may lead to excessive deformation or even damage of the pipe. In this study, the mechanical characteristics of a glass fibre reinforced unbonded flexible pipe are investigated under radial compression loading. In the theoretical analysis, the hoop reinforcement layer of the pipe is considered equivalent to an orthotropic circular tube. An analytical equation for calculating the radial stiffness of the circular tube per unit length is then derived based on the classical elastic theory of the ring. Radial compression tests are carried out with a universal testing machine and displacement loading within the elastic deformation range is applied to two 500 mm long samples. A 3D numerical model is established to simulate the compression process of the flexible pipe, through which the distribution characteristics of the displacement, strain and stress of the hoop reinforcement layer are also obtained. The load-displacement curves obtained from the tests and numerical model are linearly fitted to calculate the radial stiffness of the pipe. The radial stiffness obtained by the numerical model is very close to that obtained by the analytical method. However, owing to factors such as material defects and initial ovality, the radial stiffness measured experimentally is lower than the analytical result.
Stromal cells support the survival of human primary chronic lymphocytic leukemia (CLL) cells through Lyn-driven extracellular vesicles
Authors: de Oliveira Thaís Dolzany , vom Stein Alexander , Rebollido-Rios Rocio , Lobastova Liudmila , Lettau Marcus , Janssen Ottmar , Wagle Prerana , Nguyen Phuong-Hien , Hallek Michael , Hansen Hinrich P. 
Published: January 2023

IntroductionIn chronic lymphocytic leukemia (CLL), the tumor cells receive survival support from stromal cells through direct cell contact, soluble factors and extracellular vesicles (EVs). The protein tyrosine kinase Lyn is aberrantly expressed in the malignant and stromal cells in CLL tissue. We studied the role of Lyn in the EV-based communication and tumor support.MethodsWe compared the Lyn-dependent EV release, uptake and functionality using Lyn-proficient (wild-type) and -deficient stromal cells and primary CLL cells.ResultsLyn-proficient cells caused a significantly higher EV release and EV uptake as compared to Lyn-deficient cells and also conferred stronger support of primary CLL cells. Proteomic comparison of the EVs from Lyn-proficient and -deficient stromal cells revealed 70 significantly differentially expressed proteins. Gene ontology studies categorized many of which to organization of the extracellular matrix, such as collagen, fibronectin, fibrillin, Lysyl oxidase like 2, integrins and endosialin (CD248). In terms of function, a knockdown of CD248 in Lyn+ HS-5 cells resulted in a diminished B-CLL cell feeding capacity compared to wildtype or scrambled control cells. CD248 is a marker of certain tumors and cancer-associated fibroblast (CAF) and crosslinks fibronectin and collagen in a membrane-associated context.ConclusionOur data provide preclinical evidence that the tyrosine kinase Lyn crucially influences the EV-based communication between stromal and primary B-CLL cells by raising EV release and altering the concentration of functional molecules of the extracellular matrix.
Presenting symptoms as prognostic measures of mental health recovery among service members with concussion
Authors: Remigio-Baker Rosemay A. , Hungerford Lars D. , Ettenhofer Mark L. , Barnard Lori L. , Babakhanyan Ida , Ivins Brian , Stuessi Keith , Monasterio Carlos Diego J. , Bailie Jason M. 
Published: January 2023

BackgroundComorbid mental illness may negatively impact recovery from concussion. This study evaluated whether the level of symptom clusters at clinic intake contribute to poor mental health recovery in concussed patients during treatment, which may in turn serve as a target intervention.ObjectiveThe objective of this study is to examine the association between the level of initial symptoms and mental health symptoms among service members with concussion.MethodsData were obtained from 483 active duty service members treated in interdisciplinary treatment programs for traumatic brain injury, all of which were concussions. Pre-treatment symptom clusters included self-reported hyperarousal, dissociation/depression, cognitive dysfunction/headache and neurological symptoms. The outcomes, clinically-relevant decreases in depressive symptoms (assessed by the 8-item Patient Health Questionnaire, PHQ-8) and PTSD symptoms (assessed by the PTSD Checklist for DSM-5, PCL-5), were defined as a decrease in PHQ-8 &gt; 5 and PCL-5 &gt; 7, respectively. Poisson regression with robust error variance was used to evaluate the relationship between the level of each symptom cluster and clinically-relevant decrease in outcomes.ResultsParticipants with higher (vs. lower) levels of pre-treatment hyperarousal and dissociation/depression symptom cluster were less likely to improve in depressive and PTSD symptoms during treatment. The level of cognitive/headache and neurological symptom clusters were not significantly associated with any symptom changes.ConclusionThese findings support the need for individualized treatment for symptoms identified and treated after determining concussion history, with particular attention to high levels of hyperarousal and dissociation/depression prior to treatment.
Microvascular impairments detected by optical coherence tomography angiography in multiple sclerosis patients: A systematic review and meta-analysis
Authors: Liu Jing , Song Shuang , Gu Xiaoya , Li Hui , Yu Xiaobing 
Published: January 2023

PurposeA systematic review and meta-analysis was conducted to investigate changes in retinal and choroidal microvasculature in patients with multiple sclerosis (MS) using optical coherence tomography angiography (OCTA).MethodsPubMed and Google Scholar were searched for studies that compared retinal and choroidal microvasculature between MS and healthy controls (HC) with OCTA. MS patients were divided into 2 groups: MS with (MSON) or without optic neuritis (MSNON).ResultsTotally, 13 studies including 996 MS eyes and 847 HC eyes were included. Compared with the HC, the vessel density of the whole superficial vascular complex (SVC) was reduced by 2.27% and 4.30% in the MSNON and MSON groups, respectively. The peripapillary vessel density was 2.28% lower and 4.96% lower in the MSNON and MSON groups, respectively, than in the HC. Furthermore, the MSON group had significant lower vessel density of the SVC (mean difference [MD] = −2.17%, P &lt; 0.01) and lower peripapillary vessel density (MD = −2.02%, P = 0.02) than the MSNON group. No significant difference was found in the deep vascular complex or choriocapillaris densities among MSNON, MSON or HC groups (P &gt; 0.05). Meta-regression analyses suggested that illness duration and the Expanded Disability Status Scale scores of MS patients were possible sources of heterogeneity (P &lt; 0.05).ConclusionThe retinal SVC and peripapillary vessel density decreased significantly in MS eyes, especially in eyes with optic neuritis. Retinal microvasculature is a potential biomarker of disease progression in MS.
Exercise reduces the anxiogenic effects of meta-chlorophenylpiperazine: The role of 5-HT2C receptors in the bed nucleus of the stria terminalis
Authors: Fox James H. , Boucher Melissa N. , Abedrabbo Khalil S. , Hare Brendan D. , Grimmig Bethany A. , Falls William A. , Hammack Sayamwong E. 
Published: January 2023

IntroductionTwo weeks of voluntary exercise in group-housed mice produces a reduction in anxiety-like behaviors across a number of different measures, including a reduction in the anxiety levels typically produced by the anxiogenic serotonergic drug m-chlorophenylpiperazine (mCPP), an agonist at 5-HT2C/2b receptors. We have previously demonstrated that 2-weeks of voluntary exercise blunted the anxiogenic effects of systemic mCPP, and we have also shown that mCPP infused into the bed nucleus of the stria terminalis (BNST) is anxiogenic. Here we follow up on these reports.MethodsIn Experiment 1 we infused several doses of mCPP into the BNST with or without the 5-HT2C antagonist SB242084. In Experiment 2, we administered mCPP into amygdala subregions and the dorsal hippocampus to investigate site specificity. In Experiment 4 we lesioned the BNST and subsequently infused mCPP systemically, and in Experiment 4 we used RNAscope® to assess BNST 5-HT2C transcripts following wheel running.ResultsBNST mCPP infusion increased acoustic startle responding, which was by 5-HT2C antagonism, while neither mCPP infused into the amygdala nor hippocampus was anxiogenic. Lesions of the BNST prevented the anxiogenic effect of systemically administered mCPP. Lastly, exercise reduced 5-HT2C transcripts in the BNST.DiscussionThese results suggest that the BNST is a critical site of action for the effects of exercise on mCPP. Together these data suggest that exercise may reduce 5-HT2C receptor function in the BNST, which may, in part, explain some of the anxiolytic effects associated with wheel running.
Association of vitamin and/or nutritional supplements with fall among patients with diabetes: A prospective study based on ACCORD and UK Biobank
Authors: He Lingfang , Ma Tianqi , Zhang Guogang , Cheng Xunjie , Bai Yongping 
Published: January 2023

AimsTo assess the associations of vitamin and/or nutritional supplements (VNS) with falls among patients with diabetes.Methods9,141 and 21,489 middle-aged participants with diabetes from Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial and UK Biobank were included. Use of VNS was collected at baseline, and fall events were recorded using annual questionnaires in ACCORD and electric records in UK Biobank during follow-up. The associations of VNS use with fall risk were analyzed using logistic regression models in ACCORD and Fine-Gray sub-distribution hazard models in UK Biobank. The role of specific supplements was also estimated in UK Biobank, adjusting for confounding factors and multiple comparisons.Results45.9% (4,193/9,141, 5.5 median follow-up years) patients in ACCORD and 10.5% (2,251/21,489, 11.9 median follow-up years) in UK Biobank experienced fall and in-patient events during follow-up, respectively. In ACCORD, VNS using was associated with an increased risk of fall (full-adjusted odds ratio [OR]: 1.26, P &lt; 0.05). In UK Biobank, despite no significant association between VNS overall and in-patient fall, vitamin B, calcium, and iron using increased the risk of falls significantly (full-adjusted hazard ratio range: 1.31–1.37, P &lt; 0.05).ConclusionsUse of specific VNS increased the risk of fall among patients with diabetes. The non-indicative use of nutritional supplements for patients with diabetes might be inadvisable.
A four oxidative stress gene prognostic model and integrated immunity-analysis in pancreatic adenocarcinoma
Authors: Wang Hao , Tian Ruo-Fei , Liang Xue , Fan Jing , Duan Zi-Chuan , Fan Xin-Yu , Zhang Jia-Jia , Yao Dong-Sheng , Chen Zhi-Nan , Li Ling 
Published: January 2023

Background and aimsPancreatic adenocarcinoma (PAAD) is highly aggressive and characterized by a poor prognosis. Oxidative stress has great impacts on the occurrence and development of tumors. However, the predictive role of oxidative stress related genes on PAAD patients’ prognosis remains unclear. In this study, we aimed to construct a prognostic model for PAAD based on oxidative stress genes and to evaluate its predictive value.MethodsThe Cancer Genome Atlas (TCGA) and three Gene Expression Omnibus (GEO) datasets were used to identify differentially expressed oxidative stress genes. Univariate Cox regression, Kaplan-Meier and multivariate Cox regression analysis were used to select genes and to construct a prognosis model. According to the median value of the model’s risk score, patients were divided into high and low risk groups, and gene set enrichment analysis (GSEA), immune infiltration and immunotherapy effect, drug resistance and the expression of immune checkpoint related genes and synthetic driver genes of T cell proliferation were analyzed. Finally, the mRNA and protein levels of four genes in PAAD were verified by the clinical proteomic tumor analysis consortium (CPTAC) database and the immunostaining of patients’ tissue.Results55 differentially expressed oxidative stress genes were identified, and four genes including MET, FYN, CTTN and CDK1 were selected to construct a prognosis model. GESA indicated that immune related pathways, metabolic pathways and DNA repair pathways were significantly enriched in the high risk group as compared to the low risk group. The frequency of genetic mutations was also significantly higher in high risk groups than that in low risk groups. Moreover, the infiltration level of 23 immune cells as well as the expression of immune checkpoint related and synthetic driver genes of T cell proliferation were significantly altered, with the better immunotherapy effect occurring in low risk group. In patient PAAD tissues, the mRNA and protein levels of these four genes were up-regulated.ConclusionWe have successfully constructed a four oxidative stress gene prognostic model that has important predictive value for PAAD patients, and this model might be a promising guidance for prognostic prediction and efficacy monitoring in clinical individualized therapy.