bluuebunny/crossref_metadata_2025_split huggingface dataset:
The January 2022 Hunga Volcano explosive eruption from the multitechnological perspective of CTBT monitoring
Authors: Donner S , Steinberg A , Lehr J , Pilger C , Hupe P , Gaebler P , Ross J O , Eibl E P S , Heimann S , Rebscher D , Plenefisch T , Ceranna L 
Published: May 2023

SUMMARYThe massive eruption of the Hunga Volcano on 15 January 2022 provides an ideal test case for reviewing established methods to discriminate and analyse source processes. Discriminating source mechanisms and identifying their origins is a key task when analysing suspicious events in the frame of the Comprehensive Nuclear-Test-Ban Treaty (CTBT). Earthquakes and explosions can be distinguished in some cases using well established methods such as inversion for the seismic moment tensor. In more complex cases the combination of analyses of the seismic, infrasonic and hydroacoustic waveform content can be of help. More challenging is the discrimination of the specific kind of explosive source such as a nuclear test and a volcano eruption based on the data from the three waveform technologies alone. Here, we apply standard techniques destined to analyse relevant events in the frame of the CTBT, that is all three waveform technologies (seismology, infrasound and hydroacoustic) and atmospheric transport modelling of radionuclides. We investigate the potential of standard analysis methods to discriminate a source and identify their possible weaknesses. We show that the methods applied here work very well to identify, investigate and discriminate an explosive event. During discrimination we could not only exclude a shear-source (i.e. earthquake) but also distinguish the volcanic explosion in contrast to a man-made explosion. However, some tasks remain difficult with the available methods. These tasks include the reliable estimation of the strength of a non-shear event and thereupon a yield estimation of a possibly CTBT relevant event. In addition to evaluating our methods, we could relate our results with specific phases of the eruption process providing a more detailed insight of what happened. Our investigations of the eruption details only provide a starting point for further in-depth analysis. However, they underline the importance of the Hunga eruption event for science. The huge amount of observations provide a unique opportunity for knowledge gain in several subdisciplines of the geosciences. In addition, although not being a nuclear test, it also provides a useful and important data set for further developing multitechnology analyses in the frame of the CTBT.
The (mis)appropriation of human rights by the new global right: An introduction to the Symposium
Authors: de Búrca Gráinne , Young Katharine G 
Published: May 2023

Abstract
The meaning of human rights has always been susceptible to multiple, and sometimes conflicting, interpretations. Yet after several decades of efforts to develop an emerging, if dispersed and overlapping, normative consensus at the regional and UN treaty-system level, as well as within domestic constitutional and legislative settings, an array of efforts at concerted legal change in the human rights field has recently appeared in different parts of the world, on the basis of a supposedly reformed characterization of human rights, including in Putin’s Russia, Erdogan’s Turkey, Modi’s India, Bolsanaro’s Brazil, and the United States under the former Trump Administration, alongside developments in Uganda, Nigeria, and Ghana. We describe these arguments and moves as appropriations—and indeed as misappropriations—when they use human rights language in the service of ends which are exclusionary, repressive, or anti-pluralist in character, highly retrogressive or reversing of previous commitments, and evasive of external monitoring or accountability. We argue that by invoking the language, tools, and framework of human rights to exclude or repress particular groups and individuals, while consolidating authority and avoiding accountability, they misappropriate a human rights system which—despite extensive contestation and critique—has been developed over a long period around certain core values including equal human dignity, inclusion, and accountability. The essays in this Symposium track a range of these actors and the strategies they are using to reshape the human rights field, examining recent moves towards transnational coordination of nationalist, populist, right-wing, and authoritarian movements. The analyses from various jurisdictions around the world focus on attempts to remake and—we argue—reverse a range of progressive achievements of the human rights system around gender, religion, property, culture, and equality.
Murine cytotoxic CD4+ T cells in the tumor microenvironment are at a hyper-maturation stage of Th1 CD4+ T cells sustained by IL-12
Authors: Lin Yung-Chang , Wu Cheng-Heng , Chen Pin-Jung , Huang Chien-Hao , Yang Chan-Keng , Dutta Avijit , Huang Ching-Tai , Lin Chun-Yen 
Published: May 2023

Abstract
The roles of tumor-infiltrating CD4+Foxp3− T cells are not well characterized due to their plasticity of differentiation, and varying levels of activation or exhaustion. To further clarify this issue, we used a model featuring subcutaneous murine colon cancer and analyzed the dynamic changes of phenotype and function of the tumor-associated CD4+ T-cell response. We found that, even at a late stage of tumor growth, the tumor-infiltrating CD4+Foxp3− T cells still expressed effector molecules, inflammatory cytokines and molecules that are expressed at reduced levels in exhausted cells. We used microarrays to examine the gene-expression profiles of different subsets of CD4+ T cells and revealed that the tumor-infiltrating CD4+Foxp3− T cells expressed not only type 1 helper (Th1) cytokines, but also cytolytic granules such as those encoded by Gzmb and Prf1. In contrast to CD4+ regulatory T cells, these cells exclusively co-expressed natural killer receptor markers and cytolytic molecules as shown by flow-cytometry studies. We used an ex vivo killing assay and proved that they could directly suppress CT26 tumor cells through granzyme B and perforin. Finally, we used pathway analysis and ex vivo stimulation to confirm that the CD4+Foxp3− T cells expressed higher levels of IL12rb1 genes and were activated by the IL-12/IL-27 pathway. In conclusion, this work finds that, in late-stage tumors, the tumor-infiltrating lymphocyte population of CD4+ cells harbored a sustained, hyper-maturated Th1 status with cytotoxic function supported by IL-12.
In vivo pharmacodynamic study of contezolid acefosamil, a prodrug of contezolid for oral and intravenous administration
Authors: Wang Xiu-Kun , Yu Jie , Xie Chun-Yang , Hu Xin-Xin , Nie Tong-Ying , Li Xue , Wang Peng-He , Li Guo-Qing , Yuan Hong , Yang Xin-Yi , Li Cong-Ran , You Xue-Fu 
Published: May 2023

Abstract

Objectives
Contezolid acefosamil is a novel O-acyl phosphoramidate prodrug of contezolid. In the current study, we aimed to systemically evaluate the efficacy of contezolid acefosamil against infections caused by multiple Gram-positive pathogens, and compare the efficacy of the prodrug by oral and intravenous administrations.

Methods
The in vivo pharmacodynamic efficacy of contezolid acefosamil was evaluated in mouse models of systemic (with five S. aureus, three S. pneumoniae and two S. pyogenes bacterial isolates) and thigh (with two S. aureus isolates) infections using linezolid as the reference agent.

Results
In both models, contezolid acefosamil administrated either orally or intravenously, demonstrated high antibacterial efficacy similar to linezolid, and the antibacterial efficacy of oral and intravenous contezolid acefosamil were comparable.

Conclusions
The high aqueous solubility and great efficacy of contezolid acefosamil support its clinical development as an injectable and oral antibiotic suitable for serious Gram-positive infections.
Characterizing terminology applied by authors and database producers to informatics literature on consumer engagement with wearable devices
Authors: Alpi Kristine M , Martin Christie L , Plasek Joseph M , Sittig Scott , Smith Catherine Arnott , Weinfurter Elizabeth V , Wells Jennifer K , Wong Rachel , Austin Robin R 
Published: May 2023

Abstract

Objective
Identifying consumer health informatics (CHI) literature is challenging. To recommend strategies to improve discoverability, we aimed to characterize controlled vocabulary and author terminology applied to a subset of CHI literature on wearable technologies.

Materials and Methods
To retrieve articles from PubMed that addressed patient/consumer engagement with wearables, we developed a search strategy of textwords and Medical Subject Headings (MeSH). To refine our methodology, we used a random sample of 200 articles from 2016 to 2018. A descriptive analysis of articles (N = 2522) from 2019 identified 308 (12.2%) CHI-related articles, for which we characterized their assigned terminology. We visualized the 100 most frequent terms assigned to the articles from MeSH, author keywords, CINAHL, and Engineering Databases (Compendex and Inspec together). We assessed the overlap of CHI terms among sources and evaluated terms related to consumer engagement.

Results
The 308 articles were published in 181 journals, more in health journals (82%) than informatics (11%). Only 44% were indexed with the MeSH term “wearable electronic devices.” Author keywords were common (91%) but rarely represented consumer engagement with device data, eg, self-monitoring (n = 12, 0.7%) or self-management (n = 9, 0.5%). Only 10 articles (3%) had terminology from all sources (authors, PubMed, CINAHL, Compendex, and Inspec).

Discussion
Our main finding was that consumer engagement was not well represented in health and engineering database thesauri.

Conclusions
Authors of CHI studies should indicate consumer/patient engagement and the specific technology investigated in titles, abstracts, and author keywords to facilitate discovery by readers and expand vocabularies and indexing.
Active Surveillance for Atypical Ductal Hyperplasia and Ductal Carcinoma In Situ
Authors: Miceli Rachel , Mercado Cecilia L , Hernandez Osvaldo , Chhor Chloe 
Published: May 2023

AbstractAtypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) are relatively common breast lesions on the same spectrum of disease. Atypical ductal hyperblasia is a nonmalignant, high-risk lesion, and DCIS is a noninvasive malignancy. While a benefit of screening mammography is early cancer detection, it also leads to increased biopsy diagnosis of noninvasive lesions. Previously, treatment guidelines for both entities included surgical excision because of the risk of upgrade to invasive cancer after surgery and risk of progression to invasive cancer for DCIS. However, this universal management approach is not optimal for all patients because most lesions are not upgraded after surgery. Furthermore, some DCIS lesions do not progress to clinically significant invasive cancer. Overtreatment of high-risk lesions and DCIS is considered a burden on patients and clinicians and is a strain on the health care system. Extensive research has identified many potential histologic, clinical, and imaging factors that may predict ADH and DCIS upgrade and thereby help clinicians select which patients should undergo surgery and which may be appropriate for active surveillance (AS) with imaging. Additionally, multiple clinical trials are currently underway to evaluate whether AS for DCIS is feasible for a select group of patients. Recent advances in MRI, artificial intelligence, and molecular markers may also have an important role to play in stratifying patients and delineating best management guidelines. This review article discusses the available evidence regarding the feasibility and limitations of AS for ADH and DCIS, as well as recent advances in patient risk stratification.
Who would own the HeLa cell line if the Henrietta Lacks case happened in present-day South Africa?
Authors: Thaldar Donrich W 
Published: May 2023

Abstract
The HeLa cell line was created in 1951 without consent from Henrietta Lacks, the person whose tissue sample was used. In 2021, the descendants of Henrietta Lacks sued a well-known biotechnology company for the profits it made from the HeLa cell line. In this article, ownership of the cell lines is investigated from a South African legal perspective by considering three possible contemporary scenarios bearing points of similarity to the Henrietta Lacks case. In the first scenario, informed consent is obtained to use a tissue sample for research and to commercialize the products of such research; in the second scenario, informed consent is materially deficient because of an honest mistake on the part of the research institution; and in the third scenario, informed consent is materially deficient due to willful disregard of the law on the part of the research institution. In the first two scenarios, ownership of the cell line created from the tissue sample would vest in the research institution, and the research participant would not have any legal action for financial compensation. However, in the third scenario, ownership of the cell line would vest in the research participant, who would be able to claim all profits made from trading the cell line. Whether the research institution acted in good faith is therefore a crucial determinant of the legal outcome.
Peripheral immune mapping and multi-omics analysis in Pd-1 inhibitor–induced myocarditis
Authors: Gao Jie , Wang Yan , Lu Lina , Ma Mingyue , Ling JiaQian , Sun Lu , Chen Yuwen , Liu Fangming , Yu Yiyi , Liu Tianshu , Wu Duojiao 
Published: May 2023

Abstract
More immune-related adverse events (irAEs) have emerged along with increased immune checkpoint inhibitor (ICI) treatment. ICI-induced myocarditis is a rare type of irAE with early onset, rapid progression, and high mortality. Its specific pathophysiological mechanism is not fully understood. In total, 46 patients with tumors and 16 patients with ICI-induced myocarditis were included. We performed single-cell RNA sequencing on CD3 + T cells, flow cytometry, proteomics, and lipidomics to improve our understanding of the disease. First, we demonstrate the clinical features of patients with PD-1 inhibitor–induced myocarditis. We then identified 18 subsets of T cells using single-cell RNA sequencing and performed comparative analysis and further verification. The composition of T cells in the peripheral blood of patients has changed remarkably. Compared with non-irAE patients, effector T cells were increased in irAE patients, while naive T cells, γδ T cells, and mucosal-associated invariant T cell cluster cells were decreased. Besides, reduced γδ T cells characterized with effector functions, increased natural killer T cells with high levels of FCER1G in patients may suggest an association with disease development. Meanwhile, the peripheral inflammatory response was exacerbated in patients, accompanied by upregulation of exocytosis as well as increased levels of multiple lipids. We provide a comprehensive overview of the composition, gene profiles, and pathway signatures of CD3+ T cells driven by PD-1 inhibitor–induced myocarditis, as well as illustrate clinical features and multi-omic characteristics, providing a unique perspective on disease progression and therapy in clinical practice.
ASM History: Restricted Funds of the American Society of Mammalogists
Authors: Cameron Guy N , Hopton Matthew E , McLaren Suzanne B 
Published: May 2023

Abstract
The American Society of Mammalogists (ASM) currently has 13 Restricted Funds intended to make financial resources available to support the mission of the Society by providing grants and awards to students, early-career mammalogists, and members who perform activities relevant to ASM. Restricted Funds are specified to support a Society objective or area of research. When initially established, the originator(s) defined the use of a Restricted Fund. However, descriptions and requirements of each Restricted Fund are not often stored in a readily available location or format making it difficult for potential applicants to determine how to proceed. We collected information on each Fund from journal articles, book chapters, minutes of ASM Board of Directors meetings, and personal communications from ASM members. Then we compiled information relevant to each Restricted Fund to centralize this information and make available the intended purpose of each Restricted Fund. Several of the Funds have reached a level to be self-sustaining at the current award amounts, but others remain in desperate need of funding to be able to support the intentions of the originators. Mammalogists recognize through their establishment of Restricted Funds that allocations from these Funds are instrumental in supporting the development of students and junior colleagues as they hone their science and contribute to the science of mammalogy.
Preclinical Disease or Risk Factor? Alzheimer’s Disease as a Case Study of Changing Conceptualizations of Disease
Authors: Schermer Maartje H N 
Published: May 2023

Abstract
Alzheimer’s Disease (AD) provides an excellent case study to investigate emerging conceptions of health, disease, pre-disease, and risk. Two scientific working groups have recently reconceptualized AD and created a new category of asymptomatic biomarker positive persons, who are either said to have preclinical AD, or to be at risk for AD. This article examines how prominent theories of health and disease would classify this condition: healthy or diseased? Next, the notion of being “at risk”—a state somewhere in-between health and disease—is considered from various angles. It is concluded that medical-scientific developments urge us to let go of dichotomous ways of understanding disease, that the notion of “risk,” conceptualized as an increased chance of getting a symptomatic disease, might be a useful addition to our conceptual framework, and that we should pay more attention to the practical usefulness and implications of the ways in which we draw lines and define concepts.
Feasibility and value of genomic profiling in cancer of unknown primary: real-world evidence from prospective profiling study
Authors: Huey Ryan W , Shah Aakash Tushar , Reddi Honey V , Dasari Priyadarsini , Topham James T , Hwang Hyunsoo , Dhillon Nishat , Willett Anneleis , Smaglo Brandon G , Estrella Jeannelyn S , Rashid Asif , Matamoros Aurelio , Overman Michael J , Choquette Linda , Omerza Greg , Kelly Kevin , Wang Xuemei , Loree Jonathan M , Rueter Jens , Varadhachary Gauri R , Raghav Kanwal 
Published: May 2023

Abstract
Real-world evidence regarding the value of integrating genomic profiling (GP) in managing cancer of unknown primary (CUP) is limited. We assessed this clinical utility using a prospective trial of 158 patients with CUP (October 2016-September 2019) who underwent GP using next-generation sequencing designed to identify genomic alterations (GAs). Only 61 (38.6%) patients had sufficient tissue for successful profiling. GAs were seen in 55 (90.2%) patients of which GAs with US Food and Drug Administration–approved genomically matched therapy were seen in 25 (40.9%) patients. A change in therapy was recommended and implemented (primary endpoint of the study) in 16 (10.1%) and 4 (2.5%) patients of the entire study cohort, respectively. The most common reason for inability to implement the profiling-guided therapy was worsening of performance status (56.3%). Integrating GP in management of CUP is feasible but challenging because of paucity of tissue and aggressive natural history of the disease and requires innovative precision strategies.
DNA methylation profile of human dura and leptomeninges
Authors: Maier Andrea Daniela , Christiansen Steffan Noe , Haslund-Vinding Jeppe , Krogager Markus Engebæk , Melchior Linea Cecilie , Scheie David , Mathiesen Tiit 
Published: May 2023

Abstract
Healthy meninges are used as control tissue in meningioma studies usually without specification of the exact meningeal layer or macroanatomical origin but the DNA methylation profile of human meninges has not been investigated on a macroanatomical level. We undertook a proof-of-principle analysis to determine whether (1) meningeal tissues show sufficiently homogenous DNA methylation profiles to function as normal control tissue without further specification and (2) if previously described location-specific molecular signatures of meningiomas correspond to region-specific DNA methylation patterns. Dura mater and arachnoid membrane specimens were dissected from 5 anatomical locations in 2 fresh human cadavers and analyzed with the Illumina Infinium MethylationEPIC array. Dura and leptomeninges showed marked differences in global DNA methylation patterns and between rostral and caudal anatomical locations. These differences did not reflect known anatomical predilection of meningioma molecular signatures. The highest numbers of differentially methylated probes were annotated to DIPC2 and FOXP1. Samples from foramen magnum showed hypomethylation of TFAP2B compared to those from remaining locations. Thus, the DNA methylation profiles of human meninges are heterogenous in terms of meningeal layer and anatomical location. The potential variability of DNA methylation data from meningiomas should be considered in studies using meningeal controls.
Kaempferitrin, a major compound from ethanol extract of Chenopodium ambrosioides, exerts antitumour and hepatoprotective effects in the mice model of human liver cancer xenografts
Authors: Su Min , Li Zhimin , Zhou Siyu , Zhang Hong , Xiao Ying , Li Wei , Shang Hongli , Li Jiao 
Published: May 2023

Abstract

Objectives：
This study aimed to investigate antitumour effect and possible toxicity of kaempferitrin, the major compound from ethanol extract of Chenopodium ambrosioides, in the mice model of human liver cancer xenografts.

Methods：
Forty mice bearing SMMC-7721 cells xenografts were divided into control group (not treated) and three groups orally administered with ethanol extract of C. ambrosioides, kaempferol (positive control) and kaempferitrin for 30 days. Antitumour effect was evaluated by measurement of tumour growth, histological examinations of tumours, flow cytometry detection of splenic CD19+ B lymphocytes and CD161+ Natural Killer cells, biochemical measurements of serum levels of tumour necrosis factor-α, interleukin-6, interferon-γ, malonaldehyde, 2,2-diphenyl-1-picrylhydrazyl and 2,2ʹ-azinobis-(3-ethylbenz thiazoline-6-sulphonate) radicals. Toxicity was evaluated by histological examinations of livers and measurements of serum levels of aspartate transaminase, alanine transaminase, total bilirubin, direct bilirubin, malonaldehyde and hepatic malonaldehyde level.

Key findings
Kaempferitrin significantly (P &lt; 0.05) decreased tumour volume, mass and cell number. Antitumour effect was due to induction of tumour cells necrosis and apoptosis, stimulation of splenic B lymphocytes, decreases of radicals and malonaldehyde. Kaempferitrin did not change liver structure, and decreased serum levels of transaminases, bilirubin, malonaldehyde and hepatic malonaldehyde level.

Conclusions
Kaempferitrin exerts antitumour and hepatoprotective effects.