bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Matters in Psoriatic Arthritis: A Comparison of Patient and Clinician Perspectives
Authors: Mease Philip J. , Husni M. Elaine , Siegel Evan , Furst Daniel E. , Mcilraith Melissa , Strand Vibeke , Hay M. Cameron 
Published: January 2025

ObjectiveThis study aimed to expand the understanding of the patient with psoriatic arthritis (PsA) experience and to compare/contrast patient and clinician prioritization of PsA dimensions.MethodsWe conducted four patients with PsA focus groups across three US rheumatology practices using mixed methods to identify attributes of PsA important to patients. Combination with extant attributes of PsA identified by a steering committee created a comprehensive list of attributes. In separate patient and physician Delphi exercises, participants distributed 100 points across items on the list according to importance as a dimension of PsA.ResultsFifty‐one items describing PsA were generated. Thirty‐eight patients and 13 clinicians completed the last Delphi rating exercise. Patients distributed points across a wider range of items than physicians. Using group mean score per item, prioritization was compared between groups. Items with the top 10 mean scores for both groups included arthritis, disease activity, pain, fatigue, physical function, and spine symptoms. Other prioritized domains showed disparity: access to care, daily activities, stiffness, future health uncertainty, and sleep quality for patients versus specific disease skin and joint manifestations, comorbidities, structural damage, and disease management goals for clinicians.ConclusionAlthough concordance between patient and clinician perspectives regarding “what matters” in PsA was seen, significant areas of discordance were uncovered. Patients highlighted concerns about care access and uncertainty about the future and impact on aspects of life beyond physical symptoms, issues not usually discussed in a clinical visit. These differential prioritizations highlight opportunities for improvement in patient–clinician communications and delineate the need for more patient‐centered research.
Inverse‐Designed Dispersive Time‐Varying Nanostructures
Authors: Garg Puneet , Fischbach Jan David , Lamprianidis Aristeidis G. , Wang Xuchen , Mirmoosa Mohammad S. , Asadchy Viktar S. , Rockstuhl Carsten , Sturges Thomas J. 
Published: January 2025

AbstractTime‐varying nanostructures allow to control the spatial and temporal properties of light. The temporal modulation of the nanostructures constitutes an additional degree of freedom to control their scattering properties on demand and in a reconfigurable manner. However, these additional parameters create a vast design space, raising challenges in identifying optimal designs. Therefore, tools from the field of photonic inverse design must be used to optimize the degrees of freedom of the system to facilitate predefined optical responses. To further develop this field, here a differentiable transition (T‐) matrix‐based inverse design framework is introduced for dispersive time‐varying nanostructures. The electron density of the material of the nanostructures is modulated non‐adiabatically as a generic periodic function of time. Using the inverse design framework, the temporal shape of the electron density can be manipulated to reach the target functionality. This computational framework is exploited, exemplarily, in two instances. First, the decay rate enhancement of oscillating dipoles near time‐varying spheres is controlled on demand. Second, using spatiotemporal metasurfaces, a system supporting asymmetric transmission of light at visible frequencies is designed. This work paves the way toward programmable spatiotemporal metasurfaces and space‐time crystals for a future generation of reconfigurable functional photonic devices.
Physics‐Based Design of Efficient Metasurface Temperature‐Adaptive Radiative Coatings
Authors: Hunt Gabriella M. , Oh Lance , Bruce Robert , Miragliotta Joseph A. , Ginn James , Warren Andrew P. , Spicer James B. , Shrekenhamer David B. 
Published: January 2025

AbstractThis work introduces a physics‐based model and detailed examination of how efficient VO2‐based, metasurface thermally‐adaptive radiative coatings (TARCs) can be designed through careful selection of the dielectric spacer material and thickness as well as tailoring of the tungsten‐doped vanadium dioxide (WxV1‐xO2 where x = 0 and 0.015) patch dimensions. This study explores how the phase and magnitude of transmission through the nanopatterned layer of the metasurface TARC are impacted by these parameters and subsequently influence the resulting contrast in emissivity between the low‐ and high‐temperature states. When these parameters are optimized, the emissive contrast (8–13 µm) is predicted to be as high as 0.725 and 0.607 respectively for the undoped and doped TARCs. Additionally, this study investigates the use of alumina (Al2O3), a dielectric spacer with significant mechanical stability, and experimentally demonstrate the realization of metasurface TARCs with notably high emissive contrast. The findings describe the fundamental limits of emissivity contrast that can be achieved with a metasurface TARC composed of a WxV1‐xO2 layer deposited atop an Al2O3 coated aluminum ground plane. Ultimately, the study provides a deeper understanding of the underlying physics of TARCs and demonstrates that metasurface engineering can be used to achieve enhanced control in tuning their emissive contrast.
Molecular Clip Strategy of Modified Sulfur Cathodes for High‐Performance Potassium Sulfur Batteries
Authors: Chen Tianyu , Min Zhiwen , Yu Zhenjiang , Zheng Mengting , Jiang Qingbin , Xu Huifang , Sun Yuanmiao , Hui Kwan San , Zha Chenyang , Lu Jun , Hui Kwun Nam 
Published: January 2025

AbstractPotassium‐sulfur (K‐S) batteries are severely limited by the sluggish reaction kinetics of the cyclooctasulfur (cyclo‐S8) electrode with low conductivity, which urgently requires a novel cathode to facilitate activity to improve sulfur utilization. In this study, using the wet chemistry method, the molecular clip of Li+ is created to replace cyclo‐S8 molecular with the highly active chain‐like S62− molecular. The molecular clip strategy effectively lowers the reaction barrier in potassium‐sulfur systems, and the stretching of S─S bonds weakens the binding between sulfur atoms, facilitating the transformation of potassium polysulfides (KPSs). The as‐prepared cathode exhibits a reversible capacity of 894.8 mAh g−1 at a current rate of 0.5 C. It maintains a long cycle life of 1000 cycles with a stable coulombic efficiency in the potassium–sulfur cells without cathode catalysts. Operando XRD and Raman spectra combined with density functional theory (DFT) calculations, revealing the high efficiency of enhanced conversion of potassium polysulfide for high‐performance K‐S batteries.
A One Stone Three Birds Paradigm of Photon‐Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy
Authors: Zeng Shuang , Chen Chen , Yu Dan , Jiang Maojun , Li Xin , Liu Xiaosheng , Guo Zhihan , Hao Yifu , Zhou Danhong , Kim Heejeong , Kang Heemin , Wang Jingyun , Chen Qixian , Li Haidong , Peng Xiaojun , Yoon Juyoung 
Published: January 2025

AbstractActivating the pyroptosis pathway of tumor cells by photodynamic therapy (PDT) for immunogenic cell death (ICD) is considered a valid strategy in pursuit of antitumor immunotherapy, but it remains a huge challenge due to the lack of reliable design guidelines. Moreover, it is often overlooked that conventional PDT can exacerbate the development of tumor immunosuppressive microenvironment, which is apparently unfavorable to clinical immunotherapy. The endoplasmic reticulum's (ER) pivotal role in cellular homeostasis and its emerging link to pyroptosis have galvanized interest in ER‐centric imaging and therapeutics. Herein, using the targeted group‐assisted strategy (TAGS), an intriguing cyclooxygenase‐2‐targeted photodynamic conjugate, Indo‐Cy, strategically created, which exploits the enzyme's overabundance in the tumoral ER, especially under proinflammatory hypoxic conditions. This conjugate, with its highly precise ER imaging, embodies a trifunctional strategy: i) innovating an electron transfer mechanism, converting the hemicyanine moiety into an oxygen‐independent type I photosensitizer, thereby navigating around the hypoxia constraints of traditional PDT; ii) executing precise ER‐targeted PDT, amplifying caspase‐1/GSDMD‐mediated pyroptosis for ICD; 3) attenuating immunosuppressive pathways by inhibiting cyclooxygenase‐2 downstream factors, including HIF‐1α, PGE2, and VEGF. Indo‐Cy's multimodal approach potently induces in vivo tumor pyroptosis and bolsters antitumor immunity, underscoring cyclooxygenase‐2‐targeted dyes' potential as a versatile oncotherapeutics.
Mitochondrial Electron Flow Dynamics Imaging for Assessing Mitochondrial Quality and Drug Screening
Authors: Ren Youxiao , Wu Ling‐Ling , Song Wenjing , Gao Yanan , Shao Litao , Lu Zhiyuan , Wang Songsong , Shao Xintian , Yu Zhenjie , Zhang Mengrui , Wu Jing , Han Liwen , Zeng Kewu , Chen Qixin 
Published: January 2025

AbstractMitochondrial quality control is paramount for cellular development, with mitochondrial electron flow (Mito‐EF) playing a central role in maintaining mitochondrial homeostasis. However, unlike visible protein entities, which can be monitored through chemical biotechnology, regulating mitochondrial quality control by invisible entities such as Mito‐EF has remained elusive. Here, a Mito‐EF tracker (Mito‐EFT) with a four‐pronged probe design is presented to elucidate the dynamic mechanisms of Mito‐EF's involvement in mitochondrial quality control. Heightened aggregation of Mito‐EF in fiber‐like healthy mitochondria compared to round‐like damaged mitochondria is demonstrated, revealed Mito‐EF aggregation correlated with mitochondrial morphological remodeling, particularly in regions undergoing mitochondrial fission and fusion, and show the Mito‐EF signal associated with mitochondrial cristae maintained by Dynamin‐Related Protein 1 (DRP1). This underscores the importance of considering Mito‐EF in assessing mitochondrial quality control parameters. A novel drug screening evaluation parameter, Mito‐EF is also introduced to screen and discover mitochondrial‐targeted therapeutic modulators. This tracker provides new avenues for investigating the role of Mito‐EF in maintaining mitochondrial homeostasis and quality control, offering a potent tool for assessing mitochondrial quality and drug screening.
Traditional Chinese Medicine Borneol‐Based Polymeric Micelles Intracerebral Drug Delivery System for Precisely Pathogenesis‐Adaptive Treatment of Ischemic Stroke
Authors: Wang Yanan , Ma Xutao , Wang Xinyuan , Liu Liru , Zhang Xue , Wang Qiuyue , Zhu Yingfei , Xu Huanhua , Yu Liangmin , He Zhiyu 
Published: January 2025

AbstractThe scarcity of effective neuroprotective agents and the presence of blood‐brain barrier (BBB)‐mediated extremely inefficient intracerebral drug delivery are predominant obstacles to the treatment of cerebral ischemic stroke (CIS). Herein, ROS‐responsive borneol‐based amphiphilic polymeric NPs are constructed by using traditional Chinese medicine borneol as functional blocks that served as surface brain‐targeting ligand, inner hydrophobic core for efficient drug loading of membrane‐permeable calcium chelator BAPTA‐AM, and neuroprotective structural component. In MCAO mice, the nanoformulation (polymer: 3.2 mg·kg−1, BAPTA‐AM: 400 µg·kg−1) reversibly opened the BBB and achieved high brain biodistribution up to 12.7%ID/g of the total administered dose after 3 h post single injection, effectively restoring intracellular Ca2+ and redox homeostasis, improving cerebral histopathology, and inhibiting mitochondrial PI3K/Akt/Bcl‐2/Bax/Cyto‐C/Caspase‐3,9 apoptosis pathway for rescuing dying neurons (reduced apoptosis cell from 59.5% to 7.9%). It also remodeled the inflammatory microenvironment in cerebral ischemic penumbra by inhibiting astrocyte over‐activation, reprogramming microglia polarization toward an anti‐inflammatory phenotype, and blocking NF‐κB/TNF‐α/IL‐6 signaling pathways. These interventions eventually reduced the cerebral infarction area by 96.3%, significantly improved neurological function, and restored blood flow reperfusion from 66.2% to ≈100%, all while facilitating BBB repair and avoiding brain edema. This provides a potentially effective multiple‐stage sequential treatment strategy for clinical CIS.
Stability of Proton Superoxide and its Superionic Transition Under High Pressure
Authors: Wang Zifan , Yang Wenge , Kim Duck Young 
Published: January 2025

AbstractUnder extreme conditions, condensed matters are subject to undergo a phase transition and there have been many attempts to find another form of hydroxide stabilized over H2O. Here, using Density Functional Theory (DFT)‐based crystal structure prediction including zero‐point energy, it is that proton superoxide (HO2), the lightest superoxide, can be stabilized energetically at high pressure and temperature conditions. HO2 is metallic at high pressure, which originates from the 𝜋* orbitals overlap between adjacent superoxide anions (O2−). By lowering pressure, it undergoes a metal‐to‐insulator transition similar to LiO2. Ab initio molecular dynamics (AIMD) calculations reveal that HO2 becomes superionic with high electrical conductivity. The possibility of creating hydrogen‐mixed superoxide at lower pressure using a (Lix,H1‐x)O2 hypothetical structure is also proposed. This discovery bridges gaps in superoxide and superionicity, guiding the design of various H‐O compounds under high pressure.
Stabilizing Lattice Oxygen of Bi2O3 by Interstitial Insertion of Indium for Efficient Formic Acid Electrosynthesis
Authors: Wang Junjie , Tang Wu , Zhu Zhaozhao , Lin Yingxi , Zhao Lei , Chen Haiyuan , Qi Xueqiang , Niu Xiaobin , Chen Jun Song , Wu Rui 
Published: January 2025

AbstractBismuth oxide (Bi2O3) emerges as a potent catalyst for converting CO2 to formic acid (HCOOH), leveraging its abundant lattice oxygen and the high activity of its Bi−O bonds. Yet, its durability is usually impeded by the loss of lattice oxygen causing structure alteration and destabilized active bonds. Herein, we report an innovative approach via the interstitial incorporation of indium (In) into the Bi2O3, significantly enhancing bond stability and preserving lattice oxygen. The optimized In‐Bi2O3‐100 catalyst achieves over 90 % Faradaic efficiency for HCOOH production across a wide potential range, in both H‐cells and flow cells, maintaining robust stability after 100 hours of continuous operation. In situ surface‐enhanced infrared absorption spectroscopy and theoretical calculations reveal that the interstitial In doping precisely tunes the adsorption of CO2* and OCHO* intermediate, facilitating rapid conversion. Further in situ Raman spectroscopy confirms the role of In bolstering the oxidized structure's stability within Bi2O3, critical for sustaining lattice oxygen during electrochemical CO2 reduction.
Boosting One‐ and Two‐Photon Excited Fluorescence of Interpenetrated Tetraphenylethene‐Based Metal–Organic Frameworks (TPE‐MOFs) by Linker Installation
Authors: He Huihui , Li Ji , Zhuang Jiayi , Huang Jinyi , Meng Yuxuan , Lin Xi , Wei Zhangwen , Zhang Liangliang , Fang Yu , Pan Mei 
Published: January 2025

AbstractImmobilizing organic chromophores within the rigid framework of metal‐organic frameworks (MOFs) augments fluorescence by effectively curtailing molecular motions. Yet, the substantial interspaces and free volumes inherent to MOFs can undermine photoluminescence efficiency, as they partially constrain intramolecular dynamics. In this study, we achieved optimization of both one‐ and two‐photon excited fluorescence by incorporating linkers into an interpenetrated tetraphenylethene‐based MOF (TPE‐MOF). This linker installation strategy enables fine‐tuning of both crystal packing density and ligand conformations. Strikingly, the desolvated MOFs exhibit remarkable two‐photon absorption (TPA) cross‐sections, reaching an impressive 8801 GM. Consequently, these materials demonstrate exceptional performance in one‐ and two‐photon excited cellular imaging of HepG2 cells. Our work introduces an innovative approach to enhancing two‐photon excited fluorescence (TPEF) and broadens the scope of research into one‐ and two‐photon excited fluorescence (1/2 PEF).
Sequential Infiltration Synthesis of Cadmium Sulfide Discrete Atom Clusters
Authors: Jayaweera Nuwanthaka P. , Havenridge Shana , Bielinski Ashley R. , Kim Kihoon , Thompson Niklas B. , Hoffman Justin M. , Wheaton Amelia M. , Sarkar Prasenjit , Pathak Rajesh , Elam Jeffrey W. , Liu Cong , Mulfort Karen L. , Martinson Alex B. F. 
Published: January 2025

AbstractExposure of soft material templates to alternating volatile chemical precursors can produce inorganic deposition within the permeable template (e.g. a polymer thin film) in a process akin to atomic layer deposition (ALD). While such sequential infiltration synthesis (SIS) processes have now been demonstrated for many metal oxides, we report an SIS process for a transition metal sulfide – CdS. Gas phase dimethyl cadmium and hydrogen sulfide precursors infiltrated into poly(4‐vinylpyridine) thin films result in the 3D‐nucleation of clusters consistent with a cubane‐type Cd4S4 core that are variably terminated with methyl, thiol and hydroxy capping ligands. First principles models and simulation of few‐atom Cd‐based clusters are consistent with electronic and vibrational spectroscopy and grazing‐incidence total X‐ray scattering measurements of 3D‐cluster‐arrays synthesized at 80 °C. The direct synthesis of few‐atom transition metal sulfide clusters within polymer thin films will provide a versatile new route to precision architectures for light‐absorbing materials including solar energy harvesting and conversion applications.
Accurate Molecular Sensing based on a Modular and Customizable CRISPR/Cas‐Assisted Nanopore Operational Nexus (CANON)
Authors: Wang Huaning , Zhao Rujian , Zhang Bing , Xiao Yao , Yu Chunmiao , Wang Yesheng , Yu Chunxu , Tang Yidan , Li Yanru , Lu Baiyang , Li Bingling 
Published: January 2025

AbstractSolid‐state nanopore is a promising single molecular detection technique, but is largely limited by relatively low resolution to small‐size targets and laborious design of signaling probes. Here we establish a universal, CRISPR/Cas‐Assisted Nanopore Operational Nexus (CANON), which can accurately transduce different targeting sources/species into different DNA structural probes via a “Signal‐ON” mode. Target recognition activates the cleavage activity of a Cas12a/crRNA system and then completely digest the blocker of an initiator. The unblocked initiator then triggers downstream DNA assembly reaction and generate a large‐size structure easy for nanopore detection. Such integration of Cas12a/crRNA with DNA assembly establishes an accurate correspondence among the input targets, output DNA structures, and the ultimate nanopore signals. We demonstrated dsDNA, long RNA (i.e., Flu virus gene), short microRNA (i.e., let‐7d) and non‐nucleic acids (i.e., Pb2+) as input paradigms. Various structural assembly reactions, such as hybridization chain reaction (HCR), G‐HCR and duplex polymerization strategy (DPS), are adapted as outputs for nanopore signaling. Simultaneous assay is also verified via transferring FluA and FluB genes into HCR and G‐HCR, respectively. CANON is thus a modular sensing platform holding multiple advantages such as high accuracy, high resolution and high universality, which can be easily customized into various application scenes.
Crystal‐Facet Engineering of Mesoporous CuS Cascade Nanoreactors Enhances Photocatalytic C−C Coupling of CO2‐to‐C2H4
Authors: Zhang Jiaming , Duan Linlin , Zhang Wei , Ma Bing , Zhang Jiangwei , Li Jinying , Wang Aixia , Guo Peiting , Zhao Dongyuan , Ma Yuzhu 
Published: January 2025

AbstractCrystal‐facet heterojunction engineering of mesoporous nanoreactors with highly redox‐active represents an efficacious strategy for the transformation of CO2 into valuable C2 products (e.g., C2H4). Herein, hollow mesoporous cube‐like CuS nanoreactors (~860 nm) with controlled anisotropic crystal‐facets are prepared through an interfacial‐confined ion dynamic migration‐rearrangement strategy. The regulation of the S2− ion concentration facilitates the modulation of the highly active (110) to (100) crystal‐facet ratios from 0.119 to 0.288, and induces the formation of anisotropic crystal‐facet heterojunctions. The controllable crystal‐facet heterojunctions trigger the directional charge carrier migration, and are accompanied with the formation of tandem S‐defect sites (Cu0‐S1@S3). Both of them promote the efficient electron‐hole pair dissociation and attain asymmetric C−C coupling. The hollow mesoporous CuS nanoreactors with optimized crystal‐facet ratio of 0.224 (HMe‐CuS‐3) deliver a high selectivity of 72.7 % for the photocatalytic reduction of CO2 to acetylene (C2H2). Further constructed Au‐(110) and Co3O4‐(100) spatially separated cascade nanoreactors (SS‐Au@Co3O4‐CuS) achieve CO2‐C2H4 photoreduction, in which the Co‐sites enhance H2O dissociation to provide protons and the protonation of *CO to *COH. The *COH is further captured by Au‐sites to accomplish the asymmetric *CO‐*COH coupling and subsequent protonation, ensuring a high C2H4 generation rate of 4.11 μmol/g/h with a selectivity as high as 90.6 %.
Synthesis and Structural Characterization of Four Bidentate Ortho‐Hydroxy Schiff Bases and Their Copper (II) Complexes: Evaluation of Biological Activities, Antioxidant Power, and Molecular Docking Studies
Authors: Boukreris Sadia , Kheddam Narimane , Youcef Mohammed Hadj , Hamini‐Kadar Nisserine , Benabdallah Tayeb 
Published: January 2025

ABSTRACTFour ortho‐hydroxy aromatic bidentate Schiff bases were synthesized along with the corresponding copper (II) complexes and characterized by various analytical methods. The spatial configurations of the metal complexes were suggested in light of the analytical results obtained. Antibacterial evaluations revealed that the ligands were more active than their Cu(II) complexes. The study of antifungal activity showed that the fungus Candida albicans was more inhibited by the ligands (HL3 and HL4) and their Cu(II) complexes (IZ = 25 mm). According to the evaluation of antioxidant potency by the DPPH method, only ligand HL4 demonstrated a comparatively low ability to scavenge free radicals compared to the ascorbic acid reference. Using the AutoDock 4.2 program, molecular docking investigations were conducted with the aim of predicting the structure–activity relationship for antibacterial qualities. Using the active sites of receptor proteins, the synthesized ligands were evaluated by molecular docking assays. A good correlation was found between the results of experimental antibacterial activity and the molecular docking data.