bluuebunny/crossref_metadata_2025_split huggingface dataset:
The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer
Authors: Kraemer Anne I. , Chong Chloe , Huber Florian , Pak HuiSong , Stevenson Brian J. , Müller Markus , Michaux Justine , Altimiras Emma Ricart , Rusakiewicz Sylvie , Simó-Riudalbas Laia , Planet Evarist , Wiznerowicz Maciej , Dagher Julien , Trono Didier , Coukos George , Tissot Stephanie , Bassani-Sternberg Michal 
Published: May 2023

AbstractOne key barrier to improving efficacy of personalized cancer immunotherapies that are dependent on the tumor antigenic landscape remains patient stratification. Although patients with CD3+CD8+ T cell-inflamed tumors typically show better response to immune checkpoint inhibitors, it is still unknown whether the immunopeptidome repertoire presented in highly inflamed and noninflamed tumors is substantially different. We surveyed 61 tumor regions and adjacent nonmalignant lung tissues from 8 patients with lung cancer and performed deep antigen discovery combining immunopeptidomics, genomics, bulk and spatial transcriptomics, and explored the heterogeneous expression and presentation of tumor (neo)antigens. In the present study, we associated diverse immune cell populations with the immunopeptidome and found a relatively higher frequency of predicted neoantigens located within HLA-I presentation hotspots in CD3+CD8+ T cell-excluded tumors. We associated such neoantigens with immune recognition, supporting their involvement in immune editing. This could have implications for the choice of combination therapies tailored to the patient’s mutanome and immune microenvironment.
Fast evaluation of the adsorption energy of organic molecules on metals via graph neural networks
Authors: Pablo-García Sergio , Morandi Santiago , Vargas-Hernández Rodrigo A. , Jorner Kjell , Ivković Žarko , López Núria , Aspuru-Guzik Alán 
Published: May 2023

AbstractModeling in heterogeneous catalysis requires the extensive evaluation of the energy of molecules adsorbed on surfaces. This is done via density functional theory but for large organic molecules it requires enormous computational time, compromising the viability of the approach. Here we present GAME-Net, a graph neural network to quickly evaluate the adsorption energy. GAME-Net is trained on a well-balanced chemically diverse dataset with C1–4molecules with functional groups including N, O, S and C6–10aromatic rings. The model yields a mean absolute error of 0.18 eV on the test set and is 6 orders of magnitude faster than density functional theory. Applied to biomass and plastics (up to 30 heteroatoms), adsorption energies are predicted with a mean absolute error of 0.016 eV per atom. The framework represents a tool for the fast screening of catalytic materials, particularly for systems that cannot be simulated by traditional methods.
Stochastic non‐cooperative game for safety control of shared control vehicle in uncertain environments
Authors: Xie Wenke , Lu Shaobo , Dai Lingfeng , Wu Quanxing 
Published: May 2023

AbstractThere are great challenges in the driving of human–machine shared control vehicles (HSCVs) in uncertain environments. Aiming at solving the collision avoidance problem of HSCV considering the uncertainty of surrounding vehicles (SVs), a human–machine cooperative control method for collision avoidance based on stochastic non‐cooperative game (SNCG) is proposed. This method realizes the safe driving of HSCV combined with the prediction of surrounding environment and constructs the interaction model between a driver and an automation system based on the game theory. Firstly, a vehicle–driver coupling model with driver's lateral and longitudinal operation characteristics is established. Next, utilizing the prediction equation, the prediction of the SV motion considering uncertainty is realized. Then, the safety constraints of HSCV are established by considering the chance constraints and the saturation characteristics of the actuators. Finally, based on the distributed stochastic model predictive control (DSMPC) method, the coupled optimization problem with chance constraints is constructed. To solve the coupled optimization problem with chance constraints, the idea of Nash equilibrium solution and the method of chance constraints tightening is adopted. The simulation results illustrate that the proposed method ensures the safe driving of HSCV under uncertain environments and realize the cooperative control between the automation system and the driver.
Gradient‐projection based super‐resolution wideband DOA estimation using non‐uniform linear arrays
Authors: Jirhande Milad Javadzadeh , Kahaei Mohammad Hossein 
Published: May 2023

AbstractA new method is developed for the Direction of Arrival (DOA) estimation of wideband sources by refining the initial estimates and posing the super‐resolution theory in a non‐convex optimization problem. A gradient‐projection method is conducted for the accurate estimation of DOAs. The proposed method can be performed by any non‐uniform linear array with no need for any focusing matrices. Moreover, a greedy search algorithm is employed to obtain initial estimates for super‐resolution implementation. Numerical simulations show the outstanding accuracy of the proposed method and more robustness to noise compared to some well‐known methods. It is also more effective for DOA estimation of adjacent sources.
Kernel‐risk‐sensitive conjugate gradient algorithm with Student's‐t distribution based random fourier features
Authors: Tang Shenjie , Li Xifeng , Bi Dongjie , Tang Yu , Xie Xuan , Li Zhenggui , Xie Yongle 
Published: May 2023

AbstractKernel‐risk‐sensitive loss (KRSL) achieves an efficient performance surface, which has been applied in the kernel adaptive filters (KAFs) successfully. However, the KRSL based KAFs use the stochastic gradient descent (SGD) method in the optimization, which usually suffer from inadequate accuracy with the slow convergence speed. In this letter, the conjugate gradient method is adopted in the optimization of KRSL function, and the problem of non‐convexity in KRSL is addressed by twice half‐quadratic (HQ) methods. For sparsification, a novel Student's‐t distribution based random Fourier feature (St‐RFF) method for performance improvement of the conventional RFF method. Thus, a novel Student's‐t distribution based random Fourier features kernel‐risk‐sensitive conjugate gradient (St‐RFFKRSCG) algorithm is proposed. Simulations on Mackey‐Glass time series prediction under non‐Gaussian noises confirm the superiorities in terms of accuracy performance, robustness, and computational cost.
New cascaded multilevel inverter with series connection of novel capacitor based basic units
Authors: Laali Sara , Nasiri‐Zarandi Reza 
Published: May 2023

AbstractThis research proposes a novel multilevel inverter based on a new capacitor basic unit. Four capacitors are deployed in this unit to provide both even and odd voltage levels. Two‐cell proposed cascaded multilevel inverters and developed cascaded multilevel inverters are evaluated in order to improve the number of output levels generated. Calculations are made for all associated equations after determining the value of the necessary DC voltage source. Additionally, both inverters' switching tables and capacitor charge and discharge modes are fully explained. The merits and disadvantages of the proposed topology are then assessed by contrasting the cascaded multilevel inverter under consideration with a number of widely used multilevel inverters. The key benefit of the suggested architecture is the increase in the number of output levels produced while using fewer power electronic devices and DC voltage sources overall. The proposed one‐cell cascaded inverter is then utilized to evaluate the performance of the proposed topology using the relevant equations, simulations, and experimental data. The simulation is carried out using the EMTDC/PSCAD software, and a lab prototype yields the experimental data.
Verbesserungspotenziale des Innovationsfonds aus der
Praxissicht
Authors: Brinkmeier Michael , Galle Georg 
Published: May 2023

ZusammenfassungDieser Artikel beschreibt wesentliche Herausforderungen, welche die Beteiligten
in den Innovationsfondsprojekten meistern mussten, und benennt
Verbesserungspotenziale für die Behebung oder Milderung. Anhand von
Praxisbeispielen werden auch strukturelle Probleme des Innovationsfonds und
deren Ursachen adressiert.
Trends in Pediatric Mild Traumatic Brain Injury During COVID-19-Related Lockdown—A Single-Center Study
Authors: Kläger Hanna E. , Nast-Kolb Benjamin , Reuter Lea , Hoffmann Florian , Juranek Sabrina , Bidlingmaier Christoph , Fabri Nicole , Schönberg Nils K.T. , Wagner Johanna , Heinen Florian , Muensterer Oliver , Zeller Christiane , Holler Anne-Sophie , Fröba-Pohl Alexandra , Bonfert Michaela V. 
Published: May 2023

AbstractBackground A relevant number of visits to pediatric emergency departments (pED) are associated with mild traumatic brain injury (mTBI). On March 16, 2020, the Bavarian government declared a first full lockdown (LD) related to the coronavirus (COVID-19) pandemic.Aim The aim of the study was to investigate the impact of LD on pediatric mTBI.Methods Retrospective chart review of presentations to a pED due to mTBI. Study periods covered LD (03/17/2020 through 05/05/2020) and the same time in 2017, 2018, and 2019 as reference period (RP). Comparative analyses were performed by Chi-square or Fisher's exact test.Results Numbers of mTBI cases decreased by half. Age distribution did not differ. A significantly higher proportion of mTBI were related to falls at home (p = 0.001). Further, a higher rate of hospital admissions (p = 0.03), a higher proportion of intensive care unit admissions (p = 0.001), a longer duration of hospital stay (p = 0.02), and a higher rate of intracranial pathologies on neuroimaging were observed during LD (p = 0.007).Conclusion The decrease in mTBI presentations is likely due to an absolute decrease in numbers related to the LD measures, combined with a hesitation to present very minor mTBI to the hospital, because of fear of being infected or not to put additional strain on the healthcare system during this healthcare crisis. On the other hand, data of those that presented with mTBI tend to reflect the more severe spectrum of mTBI.
Knockdown of CENPN Inhibits Glucose Metabolism and Induces G1 Arrest
in Esophageal Cancer Cells by Regulating PI3K/AKT Signaling
Pathway
Authors: Xu Shasha , Wei Xing 
Published: May 2023

AbstractEsophageal carcinoma (ESCA) is a deadly malignancy with an increasing incidence
year by year. The purpose of this study was to explore the function of CENPN in
ESCA. Based on TCGA public data platform, the transcription level of CENPN in
ESCA was analyzed. Subsequently, ESCA cells with CENPN overexpression or
knockdown were constructed. The proliferation and migration levels of ESCA cells
were evaluated by CCK-8, colony formation assay, and transwell analysis. Western
blotting was used to detect protein levels associated with CyclinD1, CDK2,
GLUT1, and PI3K/AKT signaling pathways. Cell cycle distribution was
measured by flow cytometry. Glucose consumption and lactate production in ESCA
cells were measured. CENPN was overexpressed in ESCA. In vitro experiments
showed that CENPN promoted the proliferation and migration of ESCA cells, and
upregulated the levels of CyclinD1, CDK2, and GLUT1, promoting the cell cycle
process, increasing glucose consumption and lactic acid production. In addition,
CENPN overexpression increased the phosphorylation levels of PI3K and AKT. The
results suggest that the abnormal expression of CENPN in ESCA may enhance the
malignant phenotype of ESCA cells by activating the PI3K/AKT signaling
pathway. CENPN is expected to be a new target for ESCA treatment.
Sialolith with Sialadenitis: A Case Study and a Proposal of a Diagnostic Algorithm
Authors: Pousya Vinisha S. , Shetty Urvashi , Shetty Pushparaja 
Published: May 2023

AbstractSialolithiasis along with sialadenitis is one of the commonly occurring salivary gland disorders. Sialadenitis is an inflammatory disease of the salivary glands. It usually occurs insidiously causing pain to the patient and may lead to development of fibrous mass of the salivary gland. The cause of sialadenitis is most commonly due to the salivary duct caliculi which is termed as sialolith or salivary stones which causes statis of saliva in the ducts. This condition is usually accompanied by pain and tenderness of the involved site. Therefore, we report a case of a male patient aged 60 years with pain in the floor of the mouth in the submandibular region which was diagnosed as submandibular sialolithiasis along with sialadenitis and propose a diagnostic algorithm.
Diagnostic Value of MRI in Placental Adhesive Disorders in Pregnancy
Authors: Sathyakumar Kirthi , Chandramohan Anuradha , Eapen Anu , Abraham Anuja 
Published: May 2023

Abstract
Background The spectrum of placental adhesive disorders (PAD) forms an important cause for emergency cesarean hysterectomy, requiring an accurate prenatal diagnosis for optimal obstetric management.
Purpose The aim of this study was to assess the utility of magnetic resonance imaging (MRI) and to identify the individual MRI features that are most useful in the evaluation of PAD.
Materials and Methods This was a retrospective review of the MRI of 24 women with abnormal placentation, confirmed using histopathology/intraoperative findings as the reference standard. Patients were categorized as negative or positive for PAD (placenta accreta, increta, and percreta) on MRI and compared with the reference standard. We assessed the diagnostic performance of MRI and the features that best correlated with the presence of PAD.
Results Among the 24 women (mean age: 29.8 years) with risk factors, 16 had PAD (6 accreta, 7 increta, and 3 percreta). There was a history of previous lower segment cesarean section and placenta previa in 14 (87.5%). MRI could identify the presence of PAD in all (100% sensitivity) and its absence in three out of eight patients (37.5% specificity). The features with highest sensitivity were intraplacental dark bands (100%), myometrial thinning/loss of interface with myometrium (100%), placental heterogeneity (75%), and uterine contour abnormality (75%).
Conclusion MRI is an important modality for the investigation of PAD in suspected cases, with excellent sensitivity and good accuracy. Identifying the presence of risk factors, low-signal-intensity bands, and thinning/loss of placental–myometrial interface will aid in its diagnosis.
Prevalence of Dental Anomalies in Various Categories of Malocclusion among Orthodontic Patients in the Kosovo Region: A Retrospective Study
Authors: Selmani Mimoza , Bukleta Manushaqe Selmani 
Published: May 2023

Abstract
Objectives The objective of this retrospective research was to investigate the prevalence and the association between dental anomalies and malocclusion in a subset of Kosovo's population.
Materials and Methods This retrospective descriptive study was conducted by recruiting 557 patients; 215 (38.6%) were males and 342 (61.4%) were females. The age range was from 7 to 44 years. The exclusion criteria were employed for the sample size, and 307 of 864 patients were excluded from the study. Malocclusion groups were divided through Angle's classification, and dental anomalies were defined according to the literature. Pretreatment panoramic radiographs, medical and dental history, study casts, and photographs were included to categorize malocclusion and identify dental anomalies (i.e., hypodontia, ectopic eruption, impaction, and diastema). The data were analyzed with IBM SPSS software version 16.0. The chi-squared test was utilized to calculate the frequency and percentages of malocclusion and dental anomalies. A p-value of 0.05 was considered statistically significant.
Results Five hundred and fifty-seven patient records from 2015 to 2020 were included. An increased prevalence of ectopic eruption (24.8%) was found in this study, whereas the least common was hypodontia (7.0%). The most common malocclusion was class I (46.9%). Vertical plane malocclusion demonstrated that 31.4% had a deep bite and 9.5% had an open bite. Most dental anomalies were significantly associated with class I malocclusion and least associated with class III malocclusion. Transverse malocclusion exhibited that 14% had anterior crossbite and 10.8% had posterior crossbite. Posterior crossbite was significantly less in the class III malocclusion group (p = 0.019).
Conclusion The prevalence of the selected dental anomalies was overall high in our study; 557 of 864 patients faced dental anomalies. An association was seen between malocclusion and dental anomalies in the Kosovan population, especially with class I malocclusion. Deep bite was prominent in the vertical plane malocclusion, whereas anterior crossbite was the most common finding in the transverse plane. Anterior crowding was prevalent in the maxilla and posterior crowding in the mandible.
Ophthalmic Manifestations of Multisystem Inflammatory Syndrome in Children
Authors: Emiroglu Melike , Bozkurt Banu , Duyan Sule Acar , Alkan Gulsum , Oz Sadiye Kubra Tuter , Sert Ahmet , Korez Muslu Kazım 
Published: May 2023

Abstract
Objective The aims of this study were to determine the prevalence and clinical features of ophthalmic involvement in multisystem inflammatory syndrome in children (MIS-C) and to evaluate its association with other organ system involvement and the severity of the disease.
Methods The demographic data and information on the ophthalmologic and other systemic organ manifestations, laboratory findings, treatment modalities, and clinical outcomes of 97 patients with MIS-C were retrospectively obtained from their hospital records. Sixty-two patients with MIS-C who were examined by ophthalmologists were included in the study. Statistical analysis was performed using R version 3.6.0, and a p-value < 0.05 was accepted as statistically significant.
Results The patients' median age was 82 months (range, 11–204 months). Of the patients, 62.9% were male. The most common systemic involvements were mucocutaneous (83.9%) and cardiovascular (82.3%). Kawasaki disease was clinically observed in 71% of the patients (incomplete form, 53.2%). Ophthalmic involvement was observed in 39 patients (62.9%). Thirty-two patients (51.6%) had conjunctival hyperemia; 29 (48.4%) lid edema; 7 follicular conjunctivitis; 3 uveitis; 2 subconjunctival hemorrhage; and 1 episcleritis. The patients with ophthalmic involvement were 6.4 times (95% confidence interval [CI], 1.49–27.48; p = 0.013) more likely to exhibit cardiac involvement and 3.53 times (95% CI, 1.35–9.63; p = 0.012) more likely to have severe disease.
Conclusion Conjunctival hyperemia, lid edema, and follicular conjunctivitis were observed in at least half of the patients with MIS-C, and those with ophthalmic involvement had a higher risk of cardiac involvement or severe disease.
Efficacy and Safety of Introduction Timolol Maleate by Manometer Microneedles among Infantile Hemangioma: A Retrospective Study in China
Authors: Yuan Lulu , Wang Jia 
Published: May 2023

Abstract
Objective The objective of the study was to compare the effective rate, cure rate, adverse reaction rate, and effective time of three methods in the treatment of infantile hemangioma, hoping to provide reference for improving the clinical therapeutic effect.
Methods This is a retrospective study of 307 infantile hemangioma patients admitted to the Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, from January 2014 to October 2021. The patients were divided into three groups. In group A, timolol maleate solution was introduced by the nano-microneedle technique (97 cases); in group B, timolol maleate drops dipped in medical swabs were applied (107 cases); and group C patients took propranolol orally (103 cases). The effective rate, cure rate, adverse reaction rate, and effective time of treatment were recorded and compared.
Results The total effective rate, total cure rate, and total adverse reaction rate of the three groups were 87.6, 65.2, and 9.4%, respectively. The results showed that the effective and cure rates of group A were higher than those of group B (92.8 and 76.3%, respectively; p < 0.05), the adverse reaction rate of group C was higher than that of group B (17.5%, p < 0.05), and the effective time of group A was shorter than that of groups B and C. In most patients, symptoms significantly improved within 2 months (p < 0.05).
Conclusion Timolol maleate introduced by nanometer microneedles is an effective and safe treatment for superficial hemangioma in infants with the highest effective and cure rates, lower incidence of adverse reactions, and the shortest effective treatment time.
What are the core concerns of policy analysis? A multidisciplinary investigation based on in-depth bibliometric analysis
Authors: Yang Yuxue , Tan Xuejiao , Shi Yafei , Deng Jun 
Published: May 2023

AbstractPolicy analysis provides multiple methods and tools for generating and transforming policy-relevant information and supporting policy evolution to address emerging social problems. In this study, a bibliometric analysis of a large number of studies on historical policy analysis was performed to provide a comprehensive understanding of the distribution and evolution of policy problems in different fields among countries. The analysis indicates that policy analysis has been a great concern for scholars in recent two decades, and is involved in multiple disciplines, among which the dominant ones are medicine, environment, energy and economy. The major concerns of policy analysts and scholars are human health needs, environmental pressures, energy consumption caused by economic growth and urbanization, and the resulting demand for sustainable development. The multidisciplinary dialog implies the complicated real-world social problems that calls for more endeavors to develop a harmonious society. A global profiling for policy analysis demonstrates that the central policy problems and the corresponding options align with national development, for example, developing countries represented by China are faced with greater environmental pressures after experiencing extensive economic growth, while developed countries such as the USA and the UK pay more attention to the social issues of health and economic transformation. Exploring the differences in policy priorities among countries can provide a new inspiration for further dialog and cooperation on the development of the international community in the future.
Mapping AC susceptibility with quantum diamond microscope
Authors: Dasika Shishir , Parashar Madhur , Saha Kasturi 
Published: May 2023

We present a technique for determining the micro-scale AC susceptibility of magnetic materials. We use the magnetic field sensing properties of nitrogen-vacancy (NV−) centers in diamond to gather quantitative data about the magnetic state of the magnetic material under investigation. A quantum diamond microscope with an integrated lock-in camera is used to perform pixel-by-pixel, lock-in detection of NV− photo-luminescence for high-speed magnetic field imaging. In addition, a secondary sensor is employed to isolate the effect of the excitation field from fields arising from magnetic structures on NV− centers. We demonstrate our experimental technique by measuring the AC susceptibility of soft permalloy micro-magnets at excitation frequencies of up to 20 Hz with a spatial resolution of 1.2 µm and a field of view of 100 µm. Our work paves the way for microscopic measurement of AC susceptibilities of magnetic materials relevant to physical, biological, and material sciences.