bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and correlates of 30-day suicidal ideation and intent: Results of the South African National Student Mental Health Survey
Authors: Bantjes J , Kessler MJ , Hunt X , Kessler RC , Stein DJ 
Published: April 2023

Background. Although suicide prevention is recognised as a priority among university students in South Africa (SA), it is unclear whatproportion of students require urgent indicated interventions and what the characteristics are of these students.Objective. To assess the prevalence and sociodemographic correlates of 30-day suicidal ideation, frequency of ideation and self-reported intention to act on ideation in the next year among a national sample of SA university students.Methods. Self-report cross-sectional data were collected online from students (N=28 268) at 17 universities across SA as part of the national student mental health survey. Students reported suicidal ideation in the past 30 days, frequency of ideation and intention to act on ideation in the next year. Data were weighted within institutions by gender and population group, and across the four main types of universities (historically white, historically disadvantaged, technical and distance learning) to correct for response rate discrepancies. Prevalence was estimated with these weighted in the total sample and across types of universities. Poisson regression with robust error variances was used to investigate associations of sociodemographic characteristics with ideation and intention to act on suicidal ideation. Results are reported as relative risks (RRs) with design-based 95% confidence intervals (CIs).Results. Thirty-day prevalence of suicidal ideation was 24.4% (standard error (SE) 0.3), with 2.1% (SE 0.1) and 4.1% (SE 0.1), respectively,reporting suicidal ideation all/almost all the time, or most of the time. A total of 1.5% (SE 0.1) of respondents reported being very likely to act on their suicidal ideation, while 3.9% (SE 0.2) were somewhat likely, 8.7% (SE 0.2) were not very likely and 85.8 (SE 0.5) either reported no suicidal ideation or that they were not at all likely to act on this ideation. Risk of suicidal ideation with high intent in the total sample was elevated among females (RR 1.9, 95% CI 1.3 - 2.7) and gender non-conforming students (RR 4.3, 95% CI 1.4 - 13.0) relative to males, black African students compared with white students (RR 3.6, 95% CI 1.9 - 7.1), students whose parents did not progress to secondary school compared with students whose parents had a university education (RR 1.6, 95% CI 1.0 - 2.5) and sexual minority students compared with heterosexual students (RR 1.9, 95% CI 1.3 - 2.6). Among students with 30-day ideation (controlling for frequency of ideation), only two of these predictors of high intent remained significant: identifying as black African (RR 2.7, 95% CI 1.4 - 5.1), and having parents with less than secondary education (RR 1.5, 95% CI 1.0 - 2.1).Conclusion. Scalable suicide prevention interventions are needed to reach the large number of SA students who report suicidal ideation with intent.
Bio-economic indicators of fisheries: impact of variations in landings and fish size on market prices in Istanbul Fish Market
Authors: Yildiz Taner , Ulman Aylin , Karakulak F. Saadet , Uzer Uğur , Demirel Nazli 
Published: April 2023

Fisheries are of immense importance to Mediterranean countries, for protein, employment and livelihoods. Studies addressing the factors affecting fish price dynamics are of interest to examine their drivers as prices often dictate target fisheries. This study investigates fish market prices in relation to landings and fish sizes from Türkiye’s largest fish market in Istanbul as the study site. A total of 39 wild marine taxa were examined for their landed catch (kg) and average prices (per unit/TRY) from 2006 to 2019. We found fish prices increased from small pelagic to medium pelagic to demersal fish. GAM model results for inter-species tests showed a strong positive effect of local maximum length (p < 0.01) and a weaker positive effect of trophic level and vulnerability (p < 0.1) on fish market price, but that landings amounts have no significant effect as a single predictor. Monthly price variations of bluefish and bonito were completely different than other species dynamics, as the last substantial commercial medium pelagic fish species left; highest monthly prices were related to the highest monthly landings for bonito and for the non-closure period for bluefish. Market prices as economic indicators for fisheries may have the potential to reveal ecosystem variations as well as socioeconomic drivers. Databases including extensive data for key fish sales centers can be used to help understand fishery dynamics from an ecosystem perspective, especially for data-poor regions like Türkiye.
Efficient Electron Transfer from an Electron‐Reservoir Polyoxometalate to Dual‐Metal‐Site Metal‐Organic Frameworks for Highly Efficient Electroreduction of Nitrogen
Authors: Yang Mengle , Wang Xinming , Gómez‐García Carlos J. , Jin Zhongxin , Xin Jianjiao , Cao Xixian , Ma Huiyuan , Pang Haijun , Tan Lichao , Yang Guixin , Kan Yuhe 
Published: April 2023

AbstractPrecise design and construction of catalysts with satisfied performance for ambient electrolytic nitrogen reduction reaction (e‐NRR) is extremely challenging. By in situ integrating an electron‐rich polyoxometalates (POMs) into stable metal organic frameworks (MOFs), five POMs‐based MOFs formulated as [FexCoy(Pbpy)9(ox)6(H2O)6][P2W18O62]·3H2O (abbreviated as FexCoyMOF‐P2W18) are created and directly used as catalysts for e‐NRR. Their electrocatalytic performances are remarkably improved thanks to complementary advantages and promising possibilities of MOFs and POMs. In particular, NH3 yield rates of 47.04 µg h−1 mgcat.−1 and Faradaic efficiency of 31.56% by FeCoMOF‐P2W18 for e‐NRR are significantly enhanced by a factor of 4 and 3, respectively, compared to the [Fe0.5Co0.5(Pbpy)(ox)]2·(Pbpy)0.5. The cyclic voltammetry curves, density functional theory calculations and in situ Fourier‐transform infrared spectroscopy confirm that there is a directional electron channel from P2W18 to the MOFs unit to accelerate the transfer of electrons. And the introduction of bimetals Fe and Co in the P2W18‐based MOFs can reduce the energy of the *N2 to *N2H step, thereby increasing the production of NH3. More importantly, this POM in situ embedding strategy can be extended to create other e‐NRR catalysts with enhanced performances, which opens a new avenue for future NH3 production for breakthrough in the bottleneck of e‐NRR.
The Synergistic Effects of Multidrug‐Loaded Nanocarriers Improve Tumor Microenvironment Responsive Chemo‐Sonodynamic Therapy of Hepatocellular Carcinoma
Authors: Gao Xiujun , Bao Ke , Zhang Yanqiu , Liu Liyan , Li Ying , Hu Chunhong , Zhao Yuqing , Lu Wei , Wei Xi 
Published: April 2023

AbstractChemotherapy works synergistically with sonodynamic therapy in a multi‐functional system and is employed to improve the therapeutic outcomes of hepatocellular carcinoma. In this study, ultrasound‐responsive multi‐functional nanoparticles (USFNPs) are loaded with dual drugs, doxorubicin, and a composite ultrasound‐sensitive agent, curcumin‐gold. The USFNPs are modified with an acid‐hydrolyzable polyethylene glycol outermost layer, making it stable in blood and normal tissues while peeling off in the acidic tumor microenvironment. The USFNPs have high specificity to liver tumor cells (Hepa 1–6 cells); can escape from lysosomes following endocytosis, and exhibit better biocompatibility. Moreover, the carriers enhance the nuclear delivery of the drugs and inhibit p‐glycoprotein (P‐gp) expression of Hepa 1–6 cells. In cancer cells, carriers convert hydrogen peroxide into oxygen, improving the hypoxic microenvironment and generating abundant superoxide anion and hydroxyl radicals. Confocal laser scanning microscopy, 1H nuclear magnetic resonance, flow cytometry, cytotoxicity, acute toxicity assays, and Western blot analysis are used to demonstrate the results. The findings suggest USFNPs as novel and potential antitumor agents for treating hepatocellular carcinoma.
3D Printing of Extracellular Matrix‐Based Multicomponent, All‐Natural, Highly Elastic, and Functional Materials toward Vascular Tissue Engineering
Authors: Isik Melis , Karakaya Ece , Arslan Tugba Sezgin , Atila Deniz , Erdogan Yasar Kemal , Arslan Yavuz Emre , Eskizengin Hakan , Eylem Cemil Can , Nemutlu Emirhan , Ercan Batur , D'Este Matteo , Okesola Babatunde O. , Derkus Burak 
Published: April 2023

Abstract3D printing offers an exciting opportunity to fabricate biological constructs with specific geometries, clinically relevant sizes, and functions for biomedical applications. However, successful application of 3D printing is limited by the narrow range of printable and bio‐instructive materials. Multicomponent hydrogel bioinks present unique opportunities to create bio‐instructive materials able to display high structural fidelity and fulfill the mechanical and functional requirements for in situ tissue engineering. Herein, 3D printable and perfusable multicomponent hydrogel constructs with high elasticity, self‐recovery properties, excellent hydrodynamic performance, and improved bioactivity are reported. The materials' design strategy integrates fast gelation kinetics of sodium alginate (Alg), in situ crosslinking of tyramine‐modified hyaluronic acid (HAT), and temperature‐dependent self‐assembly and biological functions of decellularized aorta (dAECM). Using extrusion‐based printing approach, the capability to print the multicomponent hydrogel bioinks with high precision into a well‐defined vascular constructs able to withstand flow and repetitive cyclic compressive loading, is demonstrated. Both in vitro and pre‐clinical models are used to show the pro‐angiogenic and anti‐inflammatory properties of the multicomponent vascular constructs. This study presents a strategy to create new bioink whose functional properties are greater than the sum of their components and with potential applications in vascular tissue engineering and regenerative medicine.
Development of a Synthetic, Injectable Hydrogel to Capture Residual Glioblastoma and Glioblastoma Stem‐Like Cells with CXCL12‐Mediated Chemotaxis
Authors: Khan Zerin Mahzabin , Munson Jennifer M. , Long Timothy E. , Vlaisavljevich Eli , Verbridge Scott S. 
Published: April 2023

AbstractGlioblastoma (GBM), characterized by high infiltrative capacity, is the most common and deadly type of primary brain tumor in adults. GBM cells, including therapy‐resistant glioblastoma stem‐like cells (GSCs), invade the healthy brain parenchyma to form secondary tumors even after patients undergo surgical resection and chemoradiotherapy. New techniques are therefore urgently needed to eradicate these residual tumor cells. A thiol‐Michael addition injectable hydrogel for compatibility with GBM therapy is previously characterized and optimized. This study aims to develop the hydrogel further to capture GBM/GSCs through CXCL12‐mediated chemotaxis. The release kinetics of hydrogel payloads are investigated, migration and invasion assays in response to chemoattractants are performed, and the GBM‐hydrogel interactions in vitro are studied. With a novel dual‐layer hydrogel platform, it is demonstrated that CXCL12 released from the synthetic hydrogel can induce the migration of U251 GBM cells and GSCs from the extracellular matrix microenvironment and promote invasion into the synthetic hydrogel via amoeboid migration. The survival of GBM cells entrapped deep into the synthetic hydrogel is limited, while live cells near the surface reinforce the hydrogel through fibronectin deposition. This synthetic hydrogel, therefore, demonstrates a promising method to attract and capture migratory GBM cells and GSCs responsive to CXCL12 chemotaxis.
Solvation Structure Modulation of High‐Voltage Electrolyte for High‐Performance K‐Based Dual‐Graphite Battery
Authors: Han Chengjun , Wang Haiyan , Wang Zelin , Ou Xuewu , Tang Yongbing 
Published: April 2023

AbstractDue to the advantages of dual‐ion batteries (DIBs) and abundant resources, potassium‐based dual‐carbon batteries (K‐DCBs) have wide application prospects. However, conventional carbonate ester‐based electrolyte systems have obvious drawbacks such as poor oxidation resistance and difficulty in sustaining the anion intercalation process at high voltages, which seriously affect the capacity and cycle performance of K‐DCBs. Therefore, a rational design of more efficient novel electrolyte systems is urgently required to realize high‐performance K‐DCBs. Herein, a solvation structure modulation strategy for the K‐DCB electrolyte systems is reported. Consequently, substantial K+ ion storage improvement at the graphite anode and enhanced bis(fluorosulfonyl)imide anion (FSI−) intercalation capacity at the graphite cathode are successfully realized simultaneously. As a proof‐of‐concept, the assembled K‐DCB exhibited a discharge capacity of 103.4 mAh g−1, and after 400 cycles, ≈90% capacity retention is observed. Moreover, the energy density of the K‐DCB full cell reached 157.6 Wh kg−1, which is the best performance in reported K‐DCBs till date. This study demonstrates the effectiveness of solvation modulation in improving the performance of K‐DCBs.
Tuning 2D Magnetism in Cobalt Monoxide Nanosheets Via In Situ Nickel‐Doping
Authors: Jiang Jian , Feng Wenyong , Wen Yao , Yin Lei , Wang Hao , Feng Xiaoqiang , Pei Yan‐li , Cheng Ruiqing , He Jun 
Published: April 2023

AbstractElement doping has become an effective strategy to engineer the magnetic properties of two‐dimensional (2D) materials and is widely explored in van der Waals layered transition metal dichalcogenides. However, the high‐concentration substitution doping of 2D nonlayered metal oxides, which can preserve the original crystal texture and guarantee the homogeneity of doping distribution, is still a critical challenge due to the isotropic bonding of closed‐packed structures. In this work, the synthesis of high‐quality 2D nonlayered nickel‐doped cobalt monoxide nanosheets via in situ atmospheric pressure chemical vapor deposition method is reported. High‐resolution transmission electron microscopy confirmed that nickel atoms are doped at the intrinsic cobalt atom sites. The nickel doping concentration is stable at ≈15%, superior to most magnetic dopants doping in 2D materials and metal oxides. Magnetic measurements showed that pristine cobalt monoxide is nonferromagnetic, whereas nickel‐doped cobalt monoxide exhibits robust ferromagnetic behavior with a Curie temperature of ≈180 K. Density functional theory calculations reveal that nickel atoms can improve the internal ferromagnetic correlation, giving rise to significant ferromagnetic performance of cobalt monoxide nanosheets. These results provide a valuable case for tuning the competing correlated states and magnetic ordering by substitution doping in 2D nonlayered oxide semiconductors.
Skin‐Adhesive, ‐Breathable, and ‐Compatible Nanopaper Electronics for Harmonious On‐Skin Electrophysiological Monitoring
Authors: Huang Yintong , Araki Teppei , Kurihira Naoko , Kasuga Takaaki , Sekitani Tsuyoshi , Nogi Masaya , Koga Hirotaka 
Published: April 2023

AbstractOn‐skin electronics, which offers an interface for extracting electrophysiological signals from skin, is intensively investigated using electrodes mounted on flexible substrates. Despite numerous efforts toward substrate design to optimize user comfort, substrates with skin‐adhesion, skin‐breathability, skin‐compatibility, mechanical endurance, sterilizability, sustainability, and biodegradability remain desirable candidates for human‐ and environment‐friendly on‐skin electronics. To this end, a wood‐derived cellulose nanofiber paper (denoted nanopaper) with customized porous nanostructures is developed in this study. The customized porous nanopaper enables water‐assisted deformation for skin‐conformability, thereby realizing outstanding skin‐adhesion force, along with high skin‐breathability and compatibility, superior to those of conventional substrates reported for on‐skin electronics. By mounting gold electrodes on the porous nanopaper and adhering them to human skin, the real‐time monitoring of electroencephalogram, electromyogram, and electrocardiogram for diagnosing the human physiological state is successfully achieved. Furthermore, the gold‐electrode‐mounted porous nanopaper affords unique characteristics including durability against skin deformation, reusability, and even sterilizability, owing to its high mechanical endurance, and thermal stabilities. Thus, the as‐prepared porous nanopaper serves a fascinating platform for human‐ and environment‐harmonious on‐skin electronics.
From Surfactants to Viscoelastic Capsules
Authors: De Angelis Gaia , Gray Natascha , Lutz‐Bueno Viviane , Amstad Esther 
Published: April 2023

AbstractMicrometer sized capsules are often used as single entities for the encapsulation and release of active ingredients, for example in food, cosmetics, and drug delivery. Important parameters that determine the stability of capsules and the release of reagents contained in them are the dimensions and composition of their shell. Most capsule shells are rather thick, thereby occupying a significant fraction of the capsule volume, or they are rigid, making the capsules fragile. This work introduces viscoelastic capsules with very thin shells of order 10 nm. Despite the thin nature of these shells, they are flexible, self‐healing, yet, for practical applications impermeable even to low molecular weight substances. These shells are formed by ionically crosslinking surfactants that are functionalized with catechol‐derivatives. This work investigates the influence of the number of chelators contained per surfactant and the crosslinking ion on the rheological properties of the membranes and relate it to the mechanical properties of the resulting capsules. This work demonstrates that these shells are impermeable to molecules as small as 340 Da even if loaded with cell culture media, indicating their potential for biomedical applications.
Effects of 3‐HAA on HCC by Regulating the Heterogeneous Macrophages—A scRNA‐Seq Analysis
Authors: Xue Chen , Gu Xinyu , Zheng Qiuxian , Shi Qingmiao , Yuan Xin , Chu Qingfei , Jia Junjun , Su Yuanshuai , Bao Zhengyi , Lu Juan , Li Lanjuan 
Published: April 2023

AbstractKynurenine derivative 3‐hydroxyanthranilic acid (3‐HAA) is known to regulate the immune system and exhibit anti‐inflammatory activity by inhibiting T‐cell cytokine secretion and influencing macrophage activity. However, the definite role of 3‐HAA in the immunomodulation of hepatocellular carcinoma (HCC) is largely unexplored. An orthotopic HCC model and treated with 3‐HAA by intraperitoneal injection is developed. Furthermore, cytometry by time‐of‐flight (CyTOF) and single‐cell RNA sequencing (scRNA‐seq) analyses are carried out to define the immune landscape of HCC. It is found that 3‐HAA treatment can significantly suppress tumor growth in the HCC model and alter the level of various cytokines in plasma. CyTOF data shows that 3‐HAA significantly increases the percentage of F4/80hiCX3CR1loKi67loMHCIIhi macrophages and decreases the percentage of F4/80loCD64+PD‐L1lo macrophages. scRNA‐seq analyses demonstrate that 3‐HAA treatment is proved to regulate the function of M1 macrophages, M2 macrophages, and proliferating macrophages. Notably, 3‐HAA inhibits the proinflammatory factors TNF and IL‐6 in multiple cell subsets, including resident macrophages, proliferating macrophages, and pDCs. This study reveals the landscape of immune cell subsets in HCC in response to 3‐HAA, indicating that 3‐HAA may be a promising therapeutic target for HCC.
Job stressors and burnout among nurses and primary‐care physicians working at a dedicated outpatient respiratory center for patients with suspected or confirmed COVID‐19
Authors: Nedić Olesja , Belkić Karen 
Published: April 2023

AbstractBackgroundHigh burnout is reported among health professionals providing in‐patient care to patients with coronavirus disease 2019 (COVID‐19). Data are lacking on job stressors and burnout among health providers working in dedicated outpatient facilities for patients with suspected or confirmed COVID‐19.MethodsThis cross‐sectional study, using a parallel mixed‐methods design, was carried out in 2021−2022 among 22 nurses and 22 primary‐care physicians working at a COVID Outpatient Respiratory Center (CORC) (100% participation). Work conditions were assessed via the nurse‐ and physician‐specific Occupational Stressor Index (OSI) and occupational records. Measures of the outcome included the Copenhagen Burnout Index and current tobacco use.ResultsTime working in CORC displayed significant multivariate associations with personal, work‐ and patient‐related burnout among physicians and current tobacco use among nurses. Total OSI scores showed adjusted odds ratios for work‐related (1.35 (1.01 ± 1.79))(1.31 (0.99 ± 1.75)) and patient‐related burnout (1.35 (1.01 ± 1.81))(1.34 (1.01 ± 1.78)) among physicians and nurses, respectively. Numerous work stressors showed significant multivariate associations with burnout and smoking. Among the stressors were: being contacted outside work hours about patients, inadequate rest breaks, many patients/shifts, difficulty taking time off, insufficient pay, frequently listening to emotionally disturbing accounts, interruptions, increased workload, time pressure, and responsibility. Heavy patient burden/time pressure was most often cited as the hardest part of work in CORC. Increased employment of staff was the most frequently suggested workplace modification. Integrative assessment reveals that increased staff could ameliorate many work stressors associated with burnout and smoking in this cohort.ConclusionsWorking in CORC is an extra burden. In crisis situations such as the COVID pandemic, more staff is needed. Lowering the total job stressor load is vital.
Apolipoprotein E Recognizes Alzheimer's Disease Associated 3‐O Sulfation of Heparan Sulfate
Authors: Mah Dylan , Zhu Yanan , Su Guowei , Zhao Jing , Canning Ashely , Gibson James , Song Xuehong , Stancanelli Eduardo , Xu Yongmei , Zhang Fuming , Linhardt Robert J. , Liu Jian , Wang Lianchun , Wang Chunyu 
Published: April 2023

AbstractApolipoprotein E (ApoE)’s ϵ4 alle is the most important genetic risk factor for late onset Alzheimer's Disease (AD). Cell‐surface heparan sulfate (HS) is a cofactor for ApoE/LRP1 interaction and the prion‐like spread of tau pathology between cells. 3‐O‐sulfo (3‐O‐S) modification of HS has been linked to AD through its interaction with tau, and enhanced levels of 3‐O‐sulfated HS and 3‐O‐sulfotransferases in the AD brain. In this study, we characterized ApoE/HS interactions in wildtype ApoE3, AD‐linked ApoE4, and AD‐protective ApoE2 and ApoE3‐Christchurch. Glycan microarray and SPR assays revealed that all ApoE isoforms recognized 3‐O‐S. NMR titration localized ApoE/3‐O‐S binding to the vicinity of the canonical HS binding motif. In cells, the knockout of HS3ST1‐a major 3‐O sulfotransferase‐reduced cell surface binding and uptake of ApoE. 3‐O‐S is thus recognized by both tau and ApoE, suggesting that the interplay between 3‐O‐sulfated HS, tau and ApoE isoforms may modulate AD risk.
Chemically Fueled Autonomous Sol→Gel→Sol→Gel→Sol Transitions
Authors: Hermans Thomas M. , Singh Nishant 
Published: April 2023

AbstractComplex non‐equilibrium phase behaviors are a hallmark of natural self‐assembling systems. Here we show how intricate phase transitions can be achieved through a chemically fueled reaction cycle to yield autonomous sol→gel→sol→gel→sol transitions. A relay of chemical transformations based on thiazinane metathesis leads to two consecutive transient gelations in a closed system. Within seconds of fuel addition to deactivated thiazinane monomers, an imine‐based hydrogel forms that consists of fibrillar microspheres. This gel quickly loses its mechanical strength and forms a solution, from which a second aldehyde‐based gel nucleates and remains stable for over one day. Overall, our reaction cycle gives rise to two consecutive re‐entrant phase transitions without any experimental intervention.