bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early structural build‐up behavior, setting mechanism, and nanostructure of alkali‐activated GGBFS mixtures
Authors: Dai Xiaodi , Aydin Serdar , Yardimci Mert Yücel , Reekmans Gunter , Adriaensens Peter , Schutter Geert De 
Published: September 2023

AbstractThe initial changes in the microstructure of alkali‐activated slag cement (AAS) characterize the rheological behavior, initial structuration, and setting times of the mixture. In this study, the relationships among the rheological behavior, solidification process, and nanostructure changes of sodium hydroxide‐activated slag (NH–AAS) and sodium silicate‐activated slag (SS–AAS) pastes over time are investigated by small amplitude oscillation shear test, isothermal calorimetry, scanning electron microscopy analyses, and 1H–29Si cross‐polarization magic‐angle spinning nuclear magnetic resonance spectroscopy (CP MAS NMR) and 29Si MAS NMR spectroscopy. Test results showed that the NH–AAS reaches its initial setting time following a continuously proceeding structuration process, whereas the SS–AAS reaches its initial setting with an abrupt increase in the structuration process. At their initial setting times, the NH–AAS and SS–AAS mixtures release similar heat and reach a similar reaction degree. The SS–AAS mixture had more N–A–S–H formation than C–A–S–H at the initial setting time. On the other hand, the amount of C–A–S–H was similar to N–A–S–H in the NH–AAS mixture. The gradual N–A–S–H gel degradation to form C–A–S–H was observed during the acceleration period for the SS–AAS mixture.
Effects of doping on electronic structure and ion diffusion of Li2FeSiO4
Authors: Wang JiaNan , Li ZhiQiang , Zhu YongZheng , Liang Yao , Cui Yan , Tao HuaLong , Song Bo , Nikiforov Alexander , Zhang ZhiHua 
Published: September 2023

AbstractFirst‐principles calculations were performed to study the crystal structure, electronic structure, and ion diffusion of sulfur‐doped Li2FeSiO4. The sulfur atoms preferred to substitute oxygen atoms around different iron atoms and the most stable configurations were chosen for each Li16Fe8Si8O32‐xSx (x = 1, 2, 3, 4) system to study the influence of sulfur concentration. Moreover, the configuration of the Li16Fe8Si8O29S3 had the least band gap (2.456 eV), which indicated the best electronic conductivity. The results of mean square displacement confirmed that lithium ions could diffuse in a two‐dimensional path in Li2FeSiO4 and S‐doped Li2FeSiO4 along the a‐axis and c‐axis. Doping sulfur was able to reduce the energy barrier for diffusion to improve the diffusion of lithium ions. The diffusion coefficient of lithium‐ion was 8 orders of magnitude larger and the diffusion rate was 7 orders of magnitude larger than that of the intrinsic system at most.
How do Australian mental health services use easy read to make information accessible for people with intellectual disability?
Authors: Newman Bronwyn , Fisher Karen R. , Trollor Julian 
Published: September 2023

AbstractIntroductionAccess to health information is a right for all people. Easy read information is one strategy used to make information accessible for people with intellectual disability. This research explored how easy read is used and the ways accessible information can address access barriers, with a focus on Australian mental health services.MethodsSemi‐structured interviews were conducted across four sites to explore how easy read was used. Participants (n = 49) were easy read users, health practitioners and staff from services providing mental health care in New South Wales, Australia. An integrated health literacy framework was used to analyse data.ResultsMost mental health staff did not use easy read or other accessible information, and did not consistently offer people with intellectual disability opportunities to understand, appraise and apply health information. This investigation confirmed the limited availability of accessible information resources, including easy read, and the importance of relationships of support when accessing health information.ConclusionPeople with intellectual disability did not routinely have access to mental health information. Substantial change is required to address this disparity.ImplicationsAgency policy and processes require change to support staff practices that uphold the right to information. Inclusive practices that incorporate using easy read in health contexts, including mental health, are needed to facilitate change.
A novel SERPINA12 variant and first European patients with diffuse palmoplantar keratoderma
Authors: Brandt E. , Harjama L. , Elomaa O. , Saarela J. , Donner K. , Lappalainen K. , Kivirikko S. , Ranki A. , Kere J. , Kettunen K. , Hannula‐Jouppi K. 
Published: September 2023

AbstractBackgroundHereditary palmoplantar keratodermas (hPPKs) comprise a heterogeneous group of skin disorders characterized by persistent palmoplantar hyperkeratosis. Loss‐of‐function variants in a serine peptidase inhibitor, SERPINA12, have recently been implicated in autosomal recessive diffuse hPPK. The disorder appears to share similarities with another hPPK associated with protease overactivity, namely Nagashima‐type PPK (NPPK) caused by biallelic variants in SERPINB7.ObjectivesThe aim of this study was to enhance the understanding of the clinical and genetic characteristics of serine protease‐related hPPKs caused by variants in SERPINA12 and SERPINB7.MethodsWhole‐exome sequencing (WES) was performed for hPPK patients. Haplotype analysis was completed for the patients with identified recessive SERPINA12 variants and their available family members. In addition, the current literature of SERPINA12‐ and SERPINB7‐related hPPKs was summarized.ResultsThe phenotype of SERPINA12‐related hPPK was confirmed by reporting three new SERPINA12 patients, the first of European origin. A novel SERPINA12 c.1100G>A p.(Gly367Glu) missense variant was identified confirming that the variant spectrum of SERPINA12 include both truncating and missense variants. The previously reported SERPINA12 c.631C>T p.(Arg211*) was indicated enriched in the Finnish population due to a plausible founder effect. In addition, SERPINA12 hPPK patients were shown to share a similar phenotype to patients with recessive variants in SERPINB7. The shared phenotype included diffuse transgradient PPK since birth or early childhood and frequent palmoplantar hyperhidrosis, aquagenic whitening and additional hyperkeratotic lesions in non‐palmoplantar areas. SERPINA12 and SERPINB7 hPPK patients cannot be distinguished without genetic analysis.ConclusionsRecessive variants in SERPINA12 and SERPINB7 leading to protease overactivity and hPPK produce a similar phenotype, indistinguishable without genetic analysis. SERPINA12 variants should be assessed also in non‐Asian patients with diffuse transgradient PPK. Understanding the role of serine protease inhibitors will provide insights into the complex proteolytic network in epidermal homeostasis.
Financial crime and punishment: A meta‐analysis
Authors: de Batz Laure , Kočenda Evžen 
Published: September 2023

AbstractWe provide the first quantitative synthesis of the literature on how financial markets react to the disclosure of financial crimes committed by listed firms. While consensus expects negative returns, the exact size of the effect is far from clear. We survey 111 studies published over three decades, from which we collect 480 estimates from event studies. Then, we perform a thorough meta‐analysis based on the most recent available techniques. We show that the negative abnormal returns found in the literature seem to be exaggerated by more than three times. Hence, the “punishment” effect, including a reputational penalty, suffers from a serious publication bias. After controlling for this bias, negative abnormal returns suggest the existence of an informational effect. We also document that accounting frauds, crimes committed in common‐law countries such as the United States, and allegations are particularly severely sanctioned by financial markets, while the information channels and types of procedures do not influence market reactions.
Self‐designed surgical guides for accurate socket shield preparation: An in vitro evaluation supported by a clinical report
Authors: Zhang Xin , Zhao Linxiao , Li Lei , Wang Jian 
Published: September 2023

AbstractPurposeTo achieve accurate socket shield preparation with newly proposed guides that are based on guiding rails and to investigate the effect of rail format (unilateral or bilateral) and rail height on the accuracy and efficiency of the guides.Materials and methodsTwo surgical guides based on grooved rails to guide the rotary instruments were produced. The first guide was used to cut the root into a labial shield with a pre‐designed form and a lingual one, while the second guide was used to reduce the socket shield to the alveolar bone crest. The CBCT and intraoral scan data were first obtained and superimposed using the software. After isolating the root which would be used as a socket shield, grooved rails were designed on two separate guide templates according to the chosen rotary instruments to obtain a labial shield with a pre‐designed form. An in vitro study was then conducted based on four cases in each group to determine the accuracy, efficiency, and optimal parameters of the guides, which was then verified with a clinical report. Comparisons between groups were performed with a one‐way analysis of variance (ANOVA, for comparison between multiple groups) and the Student‐Newman‐Keuls test (for comparison between two groups).ResultsWith these two guides, the root can be divided into two pieces, including a palatal one and a labial one with a pre‐designed form within a short time. Guide templates with bilateral rails more than 7 mm in height and those with unilateral rails 9 mm in height significantly increased the surgery accuracy, showing accurate shield preparation and decreased bone injury. Moreover, the guides with bilateral rails of more than 5 mm significantly decreased the surgery time for shield preparation. The presented case further verified the accuracy and efficiency of the guides.ConclusionsThe newly proposed guides can help to accurately prepare the socket shield, resulting in long‐term stability of peri‐implant tissues. Moreover, bilateral guiding rails with a height of 7–9 mm are recommended in such a guided socket shield surgery.
Lentil (Lens culinaris), a new host of Alternaria chlamydosporigena
Authors: Kouadri Mohamed El Amine , Bekkar Ahmed Amine , Zaim Souad 
Published: September 2023

AbstractDuring a survey conducted in June 2019, chlorosis symptoms were observed on lentil leaves in a field located at Relizane, Algeria. Based on morphological and molecular identification, the pathogen was identified as Alternaria chlamydosporigena. A pathogenicity test was carried out and Koch's postulates were verified and fulfilled. To our best knowledge, this is the first report of A. chlamydosporigena as new pathogen on lentil worldwide.
Characterization of monogalactosyldiacylglycerol synthases in Gracilariopsis lemaneiformis and their potential roles in the fading of the thallus
Authors: Zhang Li , Yuan Quan , Hu Chaoyang , Sun Xue , Gong Yifu , Xu Nianjun 
Published: September 2023

AbstractMembrane lipids play essential roles in regulating physiological properties in higher plants and algae. Monogalactosyldiacylglycerol (MGDG) is a major thylakoid membrane lipid, and it is an important source of polyunsaturated fatty acids for cells, plays a key role in the biogenesis of plastids, and maintains the function of the photosynthetic machinery. Several studies have indicated that the knockdown of MGDG synthase results in membrane lipid remodeling, albino seedlings, and changes in photosynthetic performance. However, the effects of MGDG synthase (MGD) inhibitors on lipids in macroalgae have not yet been clarified. Here, we characterized the effects of MGD inhibitors (ortho‐phenanthroline and N‐ethylmaleimide) on the composition of the fatty acids observed in MGDG and digalactosyldiacylglycerol (DGDG) in Gracilariopsis lemaneiformis using electrospray ionization–mass spectrometry. The most abundant MGDG species contained 16:0/18:1 (sn‐1/sn‐2) fatty acids, and the most dominant DGDG species contained 20:5/16:0 (sn‐1/sn‐2) fatty acids. Measurements of photosynthetic pigments and photosynthetic parameters revealed that photosynthesis of G. lemaneiformis was impaired. Principal component analysis and Spearman's correlation analysis revealed interactions between specific MGDG structural composition patterns and key metabolites involved in photosynthesis, indicating that 20:4/16:0 (sn‐1/sn‐2) MGDG and 16:0/18:1 (sn‐1/sn‐2) MGDG affect the structure and function of phycobilisomes and thus the color of G. lemaneiformis. Three genes (GlMGD1, GlMGD2, and GlMGD3) were cloned and identified. The addition of N‐ethylmaleimide to G. lemaneiformis did not affect the abundance of GlMGD mRNA, and the abundance of transcripts was significantly decreased by ortho‐phenanthroline.
A retrospective study of sinonasal tumors in 182 dogs treated with stereotactic radiotherapy (3 × 10 Gy) (2010‐2015)
Authors: Yoshikawa Hiroto , Lafferty Mary H. , Griffin Lynn R. , LaRue Susan M. 
Published: September 2023

AbstractBackgroundStereotactic radiotherapy (SRT) is an emerging treatment for sinonasal tumors in dogs. Reported results regarding tumor control and incidence of acute and late radiation morbidities are inconsistent.ObjectivesTo determine treatment efficacy and prognostic indicators of SRT in dogs with sinonasal tumors and to quantify acute and late radiation morbidities.AnimalsOne hundred and eighty‐two client‐owned dogs with sinonasal tumors diagnosed cytologically, histologically, or radiographically that underwent SRT.MethodsSingle‐arm retrospective study by reviewing medical records of dogs treated with SRT (10 Gy × 3) between 2010 and 2015. Kaplan‐Meier analysis was used to determine overall survival (OST; from the first day of SRT to death by any cause) and disease‐specific survival times (DSST; OST but censoring tumor/treatment‐unrelated death). Tumors were staged using modified Adams criteria.ResultsMedian OST and DSST of dogs treated with 1 course of SRT was 441 (95% CI: 389‐493 days) and 482 (428‐536 days) days, respectively with skin/oral cavity acute morbidities observed in 3% of dogs. DSST in dogs with stage 4 disease showed no statistical difference compared to other stages (P = .64). Oro‐nasal (n = 2) or naso‐cutaneous (n = 11) fistula development occurred in 7.1% of dogs with median time of 425 days (range: 83‐1733 days). Possible chronic rhinitis after SRT was recorded in 54 of 88 dogs (61%) where information was available.Conclusions and Clinical ImportanceResults are comparable to other reports of treatment of SRT. Acute morbidities were minimal. Modified Adams stage scheme appeared to be inappropriate for prognostication for dogs with sinonasal tumors treated with SRT.
Serum anandamide and lipids associated with linoleic acid can distinguish interstitial cystitis/bladder pain syndrome from overactive bladder: An exploratory study
Authors: Torimoto Kazumasa , Ueda Tomohiro , Gotoh Daisuke , Kano Kuniyuki , Miyake Makito , Nakai Yasushi , Hori Shunta , Morizawa Yosuke , Onishi Kenta , Shimizu Takuto , Tomizawa Mitsuru , Aoki Junken , Fujimoto Kiyohide 
Published: September 2023

AbstractObjectivesDiagnosing interstitial cystitis/bladder pain syndrome presents a major challenge because it relies on subjective symptoms and empirical cystoscopic findings. A practical biomarker should discriminate diseases that cause increased urinary frequency, particularly overactive bladder. Therefore, we aimed to identify blood biomarkers that can discriminate between interstitial cystitis/bladder pain syndrome and overactive bladder.MethodsWe enrolled patients with Hunner‐type interstitial cystitis (n = 20), bladder pain syndrome (n = 20), and overactive bladder (n = 20) and without lower urinary tract symptoms (controls, n = 15) at Ueda Clinic and Nara Medical University Hospital from February 2020 to August 2021. The degree of interstitial cystitis/bladder pain syndrome symptoms was evaluated using the interstitial cystitis symptom and problem indices. Metabolomics analysis was performed on 323 serum metabolites using liquid chromatography time‐of‐flight mass spectrometry.ResultsIn the Hunner‐type interstitial cystitis or bladder pain syndrome group, we observed smaller relative areas, including anandamide, acylcarnitine (18:2), linoleoyl ethanolamide, and arachidonic acid, compared to those in the overactive bladder or control group. Notably, the differences in the relative areas of anandamide were statistically significant (median: 3.950e‐005 and 4.150e‐005 vs. 8.300e‐005 and 9.800e‐005), with an area under the curve of 0.9321, demonstrating its ability to discriminate interstitial cystitis/bladder pain syndrome.ConclusionsSerum anandamide may be a feasible diagnostic biomarker for interstitial cystitis/bladder pain syndrome. Reduced serum anandamide levels may be associated with pain and inflammation initiation, reflecting the pathology of interstitial cystitis/bladder pain syndrome. Furthermore, our findings suggest that abnormal linoleic acid metabolism may be involved in the pathogenesis of interstitial cystitis/bladder pain syndrome.
Genetic loci associated with Fusarium wilt resistance in tomato (Solanum lycopersicum L.) discovered by genome‐wide association study
Authors: Thanyasiriwat Thanwanit , Tongyoo Pumipat , Saman Prakob , Suwor Patcharaporn , Sangdee Aphidech , Kawicha Praphat 
Published: September 2023

AbstractFusarium wilt (FW), caused by Fusarium oxysporum f. sp. lycopersici (Fol), has impacted global tomato production. This study aims to identify single nucleotide polymorphisms (SNPs) and candidate genes associated with FW resistance against different Fol isolates in tomato accessions using genome‐wide association studies (GWAS). Ninety‐four tomato accessions were evaluated for FW resistance and subjected to GWAS analysis. Broad‐spectrum tomato accessions demonstrated resistance to Fol in at least two isolates, exhibiting a disease severity index (DSI) of 0%. Thirty‐two SNP loci were significantly linked to the DSI of Fol isolates TFPK401, BK2269 and NP‐T4, clustering on chromosome 6. Among these, 12 common significant SNPs were associated with the DSI of at least two Fol isolates, while four unique SNPs were specific to TFPK401 or NP‐T4. Furthermore, candidate genes associated with disease response to Fol infection were identified within a 37.9–41 Mb region flanking the SNPs. These findings contribute to a deeper understanding of resistance mechanisms against Fol infection in tomatoes, potentially aiding the development of effective breeding strategies for Fusarium wilt resistance.
Ultrafast excited state dynamics of isocytosine unveiled by femtosecond broadband time‐resolved spectroscopy combined with density functional theoretical study
Authors: Ma Chensheng , Xiong Qingwu , Lin Jingdong , Wong Allen Ka‐Wa , Wang Mingliang , Kwok Wai‐Ming 
Published: September 2023

AbstractIsocytosine, having important applications in antivirus and drug development, is among the building blocks of Hachimoji nucleic acids. In this report, we present an investigation of the excited state dynamics of isocytosine in both protic and aprotic solvents, which was conducted by a combination of methods including steady‐state spectroscopy, femtosecond broadband time‐resolved fluorescence, and transient absorption. These methods were coupled with density functional and time‐dependent density functional theory calculations. The results of our study provide the first direct evidence for a highly efficient nonradiative mechanism achieved through internal conversion from the ππ* state of the isocytosine keto‐N(3)H form occurring within subpicoseconds and picoseconds following photo‐excitation. Our study also unveils a crucial role of solvent, particularly solute–solvent hydrogen bonding, in determining the tautomeric composition and regulating the pathways and dynamics of the deactivation processes. The deactivation processes of isocytosine in the solvents examined are found to be distinct from those of cytosine and the case known for isocytosine in the gas phase mainly due to different tautomeric forms involved. Overall, our findings demonstrate the high photo‐stability of isocytosine in the solution and showcase the remarkable effect of covalent modification in altering the spectral character and excited state dynamics of nucleobases.
Making sense of the Ukraine war: Geographers should not be afraid of geography
Authors: Megoran Nick 
Published: September 2023

AbstractIn this commentary I respond to the editor's dual invitation to offer critical geographical understandings of the Ukraine war and to reply to Ian Klinke's (Klinke, 2023) specific criticisms of my arguments about the role of NATO expansion in it. I suggest that first, we should recognise that geographical factors are crucial in understanding why the war occurred. Second, we need to theorise how geographical imaginations influence international relations and have done here in the form of NATO expansion. Finally, we should explore counter‐mappings of European futures in ways that could help us move towards a resolution of this terrible war.
Transfusion medicine education delivery in Rwanda: Adapting Transfusion Camp to a resource‐limited setting
Authors: Skelton Teresa , Nizeyimana Francoise , Pendergrast Jacob , Hagumimana Justin , Masaisa Florence , Kanyamuhunga Aimable , Gashaija Christopher , Callum Jeannie , Pavenski Katerina , Khandelwal Aditi , Lieberman Lani , Chargé Sophie , Kapitany Casey , Morgan Mary , Meirovich Harley , Lin Yulia 
Published: September 2023

AbstractBackgroundDue to few teaching faculty, resource‐limited settings may lack the education curricula providers need for safe practice. As safe surgery becomes an increasing priority worldwide, it is essential to improve access to critical education content including in transfusion medicine. Transfusion Camp is a longitudinal curriculum, shown to increase knowledge in postgraduate trainees. The objective was to develop a sustainable bilateral partnership between Rwanda and Canada, and to integrate Transfusion Camp into the existing curriculum of the School of Medicine and Pharmacy at University of Rwanda.MethodsA Transfusion Camp pilot course was initiated through collaboration of experts in Rwanda and Canada. Planning occurred over 6 months via online and in‐person meetings. Canadian teaching faculty adapted course content via iterative discussion with Rwandan faculty. Final content was delivered through online pre‐recorded lectures by Canadian Faculty, and in‐person small‐group seminars by Rwandan Faculty. Project feasibility was assessed through structured evaluation and informal debriefing.ResultsTwenty‐seven postgraduate trainees were present for the pilot course, of whom 21 (78%) submitted evaluation forms. While the structure and content of the adapted Transfusion Camp curriculum were well‐received, the majority of respondents indicated a preference for in‐person rather than pre‐recorded lectures. Debriefing determined that future courses should focus on continuing education initiatives aimed at physicians entering or already in independent practice.ConclusionA partnership between universities and blood operators in high‐resource and resource‐limited countries results in a transfusion medicine curriculum that is locally applicable, multidisciplinary, and supportive of learning benefitting the learners and educators alike.