bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications Following Open Versus Minimally Invasive Resection of Gastric Adenocarcinoma
Authors: Bates Kelly R. , Jones Whitney , Liggett Marjorie R. , Zaza Norah N. , Vitello Dominic J. , Bentrem David J. 
Published: January 2025

ABSTRACTBackground and ObjectivesGastric adenocarcinoma (GA) is commonly treated with open or minimally invasive surgery (MIS). The preferred surgical approach remains unclear. This study sought to assess utilization over time, compare complication rates by surgical approach, and identify predictors of experiencing complications.MethodsPatients who underwent GA resection from 2016 to 2022 were identified in the American College of Surgeons National Surgical Quality Improvement Program and compared based on receipt of open gastrectomy versus MIS. Complication rates were compared with χ2 tests. Predictors of experiencing complications or receiving MIS were assessed using multivariable Poisson regressions with robust variance.ResultsOut of 4,429 patients, most underwent open gastrectomy versus MIS (84.2% vs. 15.9%). MIS uptake did not increase. Open gastrectomy patients experienced more major complications (18.5% vs. 13.1%), higher perioperative mortality (1.53% vs. 0.57%), and longer hospital stays (7 vs. 5 days) compared to MIS patients (all p values < 0.01). MIS patients had a decreased risk of experiencing any complications (RR: 0.7, 95% CI: 0.5–0.8). Non‐white patients were less likely to receive MIS.ConclusionsMIS is associated with a decreased risk of experiencing complications compared to open gastrectomy for GA, yet its utilization has plateaued. Sociodemographic predictors of receipt of MIS indicate potential disparities in accessing certain treatments.Summary

The preferred surgical approach for gastric cancer is unclear. This analysis of the American College of Surgeons National Surgical Quality Improvement Program compared complication rates of open gastrectomy with minimally invasive surgery (MIS).
MIS was associated with a decreased risk of experiencing complications, yet utilization has plateaued.
A Novel Dynamic Growth Rod Inducing Spinal Growth Modulation for the Correction of Spinal Deformities
Authors: Xu Yangyang , Lu Da , Zhang Le , Zhang Shijia , Wu Yong , Li Heng , Pei Baoqing , Wu Xueqing 
Published: January 2025

ABSTRACTBackgroundGrowth rods are the gold standard for treating early‐onset scoliosis (EOS). However, current treatments with growth rods do not optimize spinal growth in EOS patients, and frequent distraction surgeries significantly increase complications, imposing considerable economic and psychological burdens on patients. An improved growth rod is urgently required to address the need for dynamic growth and external regulation.MethodsThis study designed a novel growth rod (NGR) with unidirectional sliding and external regulation capabilities. By establishing a three‐dimensional model of the EOS spine, we simulated the implantation of traditional growth rods (TGR) and NGR. We applied a compressive load of 400 N to test axial stiffness and a moment of 1 NM to assess bending stiffness under six different conditions. Additionally, we evaluated the range of motion (ROM) of the spinal joints, and the distribution of Von Mises stress in vertebrae, intervertebral discs, and the growth rods, and calculated the axial force, moment, fatigue life, and strain energy of the device.ResultsNGR exhibits higher axial compression and torsional stiffness than TGR and the Intact group. Additionally, Von Mises stress values for NGR are higher than those for TGR across all operating conditions, albeit with slightly lower total strain energy than TGR. Although Von Mises stress in NGR concentrates near the screw fixation, the fatigue life remains adequate for basic living requirements.ConclusionOverall, NGR demonstrates superior stiffness and stress distribution. NGR's distraction‐based implant features a unidirectional sliding component with a spring‐driven mechanism for dynamic correction and a novel non‐invasive extension mechanism to reduce infections. Compared to leading EOS implants, NGR offers improved stability, showing promise for enhancing EOS surgical interventions.
FOXA1 activates NOLC1 transcription through NOTCH pathway to promote cell stemness in lung adenocarcinoma
Authors: Li Ji‐Fa , Bao Xiao‐Qiong , Yu Wen‐Wen , Chen Xiang‐Xiang , Ni Yang‐Yang , Shi Yu‐Bo , Wang Jin‐Cong , Sun Yang‐Jie , Chen Ai‐Li , Zhou Wei‐Long , Ye Hua 
Published: January 2025

AbstractTumor cell stemness plays a pivotal role in generating functional heterogeneity within tumors and is implicated in essential processes such as drug resistance, metastasis, and cell proliferation. Therefore, creating novel tumor diagnostic techniques and therapeutic plans requires a knowledge of the possible processes that preserve the stem cell‐like qualities of cancers. Bioinformatics analysis of NOLC1 expression in lung adenocarcinoma (LUAD) and prediction of its upstream transcription factors and their binding sites were completed. RT‐qPCR detection of NOLC1 and FOXA1 expression, colony formation assay of cell proliferation, Transwell assay of cell invasion, sphere formation assay of cell stemness, western blot detection of CD133, OCT4, GLI1, NOTCH1 and Hes1 expression, CCK‐8 assay of IC50 value of cisplatin, and ChIP and dual‐luciferase reporter validation of binding relationship between NOLC1 and FOXA1 were done. NOLC1 expression was elevated in LUAD cells and tissues. Decreased NOLC1 expression inhibited the proliferation and invasive capacity of LUAD cells, prevented LUAD cells from becoming stem cells, and suppressed cisplatin resistance in the cells. Rescue tests demonstrated that NOLC1 activated the NOTCH pathway to increase the stemness of LUAD cells and promoted cisplatin resistance in LUAD cells. The activation of NOLC1 transcription by FOXA1 was validated by bioinformatics prediction and molecular verification, and the FOXA1/NOLC1 axis enhanced the stemness of LUAD cells. Activation of NOLC1 transcription by FOXA1 through NOTCH pathway promoted stemness of LUAD. FOXA1/NOLC1 axis is expected to become a new target for inhibiting stemness of LUAD cells.
Increasing Incidence of Facial Nerve Disorders in the United States from 2007 to 2022
Authors: Wei Eric X. , Green Allen , Pepper Jon‐Paul , Akkina Sarah R. 
Published: January 2025

BackgroundIncidence data on Facial Nerve Disorders (FND) and Bell's palsy are currently limited. Prior epidemiological studies have estimated the incidence rate of Bell's palsy to be between 11 and 53/100,000 individuals, although the most cited incidence data are from single regions or municipalities, many of which are outdated from several decades ago.MethodsThis was a retrospective cohort study of US adults from 2007 to 2022 using the Merative™ Marketscan® Research Databases. Trends in the incidence of FND were described overall and by specific sociodemographic groups, including age, sex, region, and insurance plan type. Chi‐squared and simple logistic regression analyses were performed.ResultsFrom 2007 to 2022, the total adult incidence of all FND was 30.5/100,000, and the total incidence of Bell's palsy alone was 24.5/100,000. Over the study period, there was a significant annual increase of 2.1 cases of FND/100,000 adults (95% Confidence Interval [CI] 1.8, 2.3; p < 0.001), and a significant total increase of 1.5 cases of Bell's palsy/100,000 adults (95% CI 1.2, 1.7; p < 0.001). The total incidence of FND was higher in males (33.1/100,000) than in females (28.4/100,000, p < 0.001), and greater in older age groups (p < 0.001). Additionally, the incidence of FND varied significantly by region (p < 0.001) and insurance plan type (p < 0.001).ConclusionsThis study provides up‐to‐date incidence rates for Bell's palsy and facial nerve disorders, based on national administrative claims data. Incidence rates of FND and Bell's palsy alone have been increasing in the United States from 2007 to 2022.Level of EvidenceIII Laryngoscope, 2025
Primary Hepatic Neuroendocrine Carcinoma Associated With Carcinoid Syndrome and Pellagra: A Case Report
Authors: Abdo Abdelmounem Eltayeb , Caminada Susanna , Mudawi Salma Barakat , Elwahab Sami Medani Abd , Rafei Ahmed , Vosinakis Christos , Pizzol Damiano , Smith Lee 
Published: January 2025

ABSTRACTCarcinoid tumours are slow‐growing neuroendocrine neoplasms mainly affecting the gastrointestinal tract, the respiratory tree, ovaries and kidneys. Approximately 20% of patients with carcinoid tumour are affected by carcinoid syndrome, characterised by chronic diarrhoea and/or flushing in the presence of systemically elevated levels of specific markers as serotonin or 5‐hydroxyindolacetic acid. Skin manifestations include flushing of the face, neck and anterior surface of the chest but after repeated and prolonged relapses, the skin lesions become fixed, acquiring a bluish‐red tint with telangiectasias. Patients may also develop pellagra skin symptoms including erythema, xerosis, scaling, hyperkeratosis and pigmentation, caused by a deficiency of tryptophan, due to its high consumption for serotonin synthesis.
Insights Into Earthworms and Fungi: Pioneering Roles in Mitigating Global Food Scarcity and Combatting Land Degradation
Authors: Chaturvedi Sadashiv , Kumar Amit , Min Liu , Mohan Khushi , Singh Nikhilesh , Kumar Rupesh 
Published: January 2025

ABSTRACTClimate change significantly impacts terrestrial ecosystems by altering soil moisture, temperature regimes, rainfall patterns, and frequency of extreme weather events. These disruptions lead to shifts in soil community structures, accelerates land degradation processes, which in turn exacerbate the global food crisis. This review explores the roles of earthworms and fungi in improving soil health and mitigating food insecurity through their contributions to nutrient cycling, soil fertility, and plant growth. Earthworms and fungi recognized as key biological agents in nutrient cycling, soil structures enhancement, and carbon sequestration. They play crucial roles in heavy metal remediation, soil quality, fostering sustainable agricultural practices such as organic farming. The review emphasizes the influence of earthworms on nutrient dynamics, particularly in response to organic residues management, soil characteristics, and field conditions. Earthworm activity positively affects soil microbial communities, which in turn impacts plant growth, even under stress factors like soil contamination and temperature extremes. Review identifies key research gaps in the understanding of earthworm and fungi distribution, performance, and their capacity for soil remediation in varied agro‐ecological contexts. In addition to biotic factors, present review also examines alternative food habits and superfoods as strategies to address zero hunger, aligning with the United Nations Sustainable Development Goals (SDGs) for zero hunger, poverty eradication, improved health, and overall well‐being. By incorporating earthworms and fungi into agricultural systems and addressing critical research needs, there is significant potential to mitigate land degradation and contribute to the alleviation of global food crises.
Serum sodium to chloride ratio and mortality on continuous ambulatory peritoneal dialysis: a multicenter retrospective study
Authors: You Jiayin , Gu Sijie , Su Ning , Feng Xiaoran , Peng Fenfen , Xu Qingdong , Zhan Xiaojiang , Wen Yueqiang , Wang Xiaoyang , Tian Na , Wu Xianfeng , Wang Niansong 
Published: January 2025

AbstractAn imbalance in the serum sodium to chloride ratio (Na/Cl) was linked to higher mortality among heart failure patients. Nonetheless, the prognostic significance of Na/Cl in individuals undergoing peritoneal dialysis (PD) remains unexplored. This study seeks to explore the association between initial Na/Cl levels and mortality in PD patients. The study, conducted across multiple centers, included 3341 patients undergoing PD from January 1, 2005, to December 31, 2021. Patients were stratified into quartiles according to baseline Na/Cl and followed up for a median of 5.77 years. To explore the association between Na/Cl levels and mortality, we employed Cox proportional hazards models, competing risks models, and restricted cubic spline analysis. Of 3341 patients, 722 patients died, including 259 cardiovascular deaths. Following adjustments for comorbidities and multiple covariates, individuals in the highest Na/Cl quartile (>1.42) exhibited lower all‐cause mortality (hazard ratio [HR] 0.63, 95% confidence interval [CI] 0.47–0.86) and cardiovascular mortality (HR 0.38, 95% CI 0.22–0.67) compared with those in the lowest quartile (<1.33). A similar pattern was also found when Na/Cl was dealt with continuous variables. Initial levels of Na/Cl at the start of PD were negatively correlated with all‐cause mortality and cardiovascular mortality in PD patients.
Dual Band Dual Polarized Aperture Coupled Based Frequency Selective Surface
Authors: Mohan Kachallai Narasimman , Bhowmick Abhijit , Choukiker Yogesh K. 
Published: January 2025

ABSTRACTA polarization rotation second order dual‐band aperture coupled based frequency selective surface (FSS) is presented in this letter. It produces different polarization rotation angle for both the bands. The corner truncated square patch resonators are used to examine dual‐band responses. The patch resonators are placed back‐to‐back through metallic aperture coupled layer in the middle. Two passband responses are obtained with sub‐patch resonator I (SPR I) and sub‐patch resonator II (SPR II) patch resonators. In first passband, two orthogonal component provide phase difference. Similarly, in second passband phase difference is occur. Thus, rotation in polarization is occurs in both passband. The prototype of the proposed FSS is fabricated and simulation results are verified with measured results.
Flexed‐Neck Flexible Nasolaryngoscopy for Evaluation of the Subglottis and Trachea in Children
Authors: Siu Jennifer M. , Wolter Nikolaus E. , Tepsich Meghan E. , Treble Alexander M. , Goh Samantha , Osborn Alex J. , Propst Evan J. 
Published: January 2025

AbstractObjectiveDetermine if a flexed‐neck posture during flexible nasolaryngoscopy (FNL) improves visualization of the subglottis.Study DesignRetrospective review of children undergoing FNL in the neutral (FNL) and flexed‐neck (FN‐FNL) positions.SettingTertiary children's hospital.MethodsFNL was performed with each child's head in neutral and flexed‐neck positions. Videos in each posture were captured and randomized. The most distal view of the subglottis in each position was evaluated with 4 rating scales: (1) subjective view (SV); of the subglottis and trachea, (2) airway grade (AG); most distal anatomical structure visualized, (3) airway area (AA); percentage of the subglottis visualized; and (4) modified Cormack‐Lehane grade.ResultsTwenty children had 80 FNL views blindly evaluated by 5 pediatric otolaryngologists. The SV, AG, and AA were all significantly better with the neck flexed compared to a neutral position (7.3 vs 3.0, interquartile range [IQR]: 2.0‐6.8, P < .001; 2.3 vs 1.5, IQR: 1.0‐2.0, P < .001; 3.4 vs 1.7, IQR: 2.3‐3.8, P = .001). There was no difference in the modified Cormack‐Lehane grade between positions. Interrater reliability was excellent or strong (0.93‐0.94, confidence interval: 0.91‐0.93).ConclusionFN‐FNL is a simple maneuver performed in children undergoing FNL that partially improves the subjective visualization of the subglottis.
Antioxidant, Antimicrobial, Anticancer, and Molecular Docking Insights into Pancratium maritimum Seeds and Flowers: A Phytochemical Approach
Authors: Sait Ertuğrul Muhammed , Balpınar Özge , Can Aytar Erdi , Aydın Betul , Incilay Torunoglu Emine , Durmaz Alper , Rossato Viana Altevir 
Published: January 2025

AbstractThis study investigates the antioxidant, antimicrobial, and anticancer properties of Pancratium maritimum L. in Sp. Pl.: 291 (1753) seeds and flowers. Antioxidant activity was assessed using DPPH free radical scavenging and iron chelation assays. Antimicrobial evaluations assessed the efficacy of the extracts against diverse microorganisms. Cell viability assays were conducted on the dukes c colon cancer (SW480), while gas chromatography‐mass spectrometry (GC‐MS) analysis facilitated the identification of bioactive compounds. The ethanol extract of P. maritimum seeds exhibited a total phenolic content of 296.89±14.53 mg GAE/g extract DW and a total flavonoid content of 361.03±20.18 mg QE/g extract DW. Conversely, the flower extract showed a total phenolic content of 95.03±7.22 mg GAE/g extract DW and a total flavonoid content of 272.12±16.42 mg QE/g extract DW. As a result, the ethanol extract of P. maritimum seeds contains higher phenolic and flavonoid contents than the flower extract. Antimicrobial evaluations demonstrated significant inhibitory effects of both seed and flower extracts, with minimum inhibitory concentration (MIC) values ranging from 25 to >50 mg/mL. Notably, the seed extract showed greater activity against E. coli and C. krusei. GC‐MS analysis identified 18 bioactive compounds in the seed extract and 16 in the flower extract, with crucial components including ethyl oleate and 5‐hydroxymethylfurfural. Additionally, cell viability assays revealed that ethanol extracts from seeds and flowers significantly reduced SW480 cell viability, particularly at doses of 750 μg/mL and 250 μg/mL, respectively. These findings underscore the therapeutic potential of P. maritimum in terms of its antioxidant, antimicrobial, and anticancer properties, highlighting its value as a natural source of antioxidants and antimicrobial agents. Furthermore, the molecular docking study emphasises strong binding interactions of key compounds, particularly ethyl oleate and hexadecanoic acid ethyl ester, with the human STARD10 protein. The biological interactions and health implications of P. maritimum provide a significant foundation for future research in drug development and therapeutic applications.
Asphyxia due to Blood Aspiration Caused by Maxillofacial Injury With Alcohol Consumption: A Forensic Autopsy Case Report and Feedback From a Forensic Medicine Perspective
Authors: Suzuki Shoken , Ohtani Maki , Matsuo Yuhei , Fukuda Masayuki , Mimasaka Sohtaro 
Published: January 2025

ABSTRACTBackgroundAirway management and hemorrhage control are important with in treatment of oro‐nasal bleeding from maxillofacial injuries.Case PresentationWe report an autopsy case of an individual who was found dead in his home and died of asphyxia due to blood aspiration caused by maxillofacial injury. Evidence of crush injury of the nose, Le Fort I fracture, C7 spinal injuries, and blood aspiration in the airways was recorded. Alcohol was detected in the blood.ConclusionMaxillofacial injury can cause “blood to flow into the airways” and may be associated with “cervical spine injury”; these more often occur under the influence of alcohol.
Long‐Term Postoperative Donor Site Musculoskeletal Morbidity after Osseous Free Flap Harvest
Authors: Chan Tyler G. , Rosado Aaron , Goyal Subir , Irizarry Rachel , Owen Robert J. , Baddour Harry Michael , Boyce Brian , Kaka Azeem , El‐Deiry Mark W. , Gross Jennifer H. 
Published: January 2025

AbstractObjectiveComplex ablative maxillary and mandibular defects often require osseous free flap reconstruction. Workhorse options include the fibula, scapula, and osteocutaneous radial forearm flap (OCRFF). The choice of donor site for harvest should be driven not only by reconstructive goals but also by donor site morbidity. The goal of this study is to evaluate the long‐term postoperative musculoskeletal morbidity at the donor site after osseous free flap harvest.Study DesignCohort study and cross‐sectional analysis.MethodsA retrospective review of patients who underwent free flap harvest at 1 of the 3 donor sites from 2015 through 2021 was performed. An additional cross‐sectional analysis at ≥1 year postoperatively was performed from 2021 to 2022 using validated patient‐reported orthopedic surveys: Disabilities of the Arm, Shoulder, and Hand for scapula or OCRFF harvest, and Foot and Ankle Ability Measure for fibula harvest.SettingSingle, high‐volume tertiary care institution.ResultsAmong 731 eligible patients, 162 (22.1%) answered the telephone surveys and were included. Functional differences between operated and nonoperated sides were 18.5% (scapula, n = 33), 13.5% (OCRFF, n = 29), and 10% (fibula, n = 98). Postoperative physical therapy (for all donor sites), ipsilateral neck dissection (for scapula and OCRFF), and extent of bony resection (for OCRFF) were not factors associated with long‐term morbidity. Acute donor site complications were most common in fibula patients and were associated with worse long‐term functional outcomes (7.5% difference; 95% confidence interval, −14.0 to −1; P = .03).ConclusionThere is acceptable long‐term musculoskeletal morbidity at the donor site after osseous free flap harvest, and patients should be counseled appropriately.
Superiority illusion in older adults: Volume and functional connectivity of the precuneus
Authors: Shidei Yuki , Matsuyoshi Daisuke , Isato Ayako , Sugihara Genichi , Takahashi Hidehiko , Yamada Makiko 
Published: January 2025

AbstractAimSuperiority illusion (SI), a cognitive bias where individuals perceive themselves as better than others, may serve as a psychological mechanism that contributes to well‐being and resilience in older adults. However, the specific neural basis of SI in elderly populations remains underexplored. This study aims to identify brain regions partially associated with SI, exploring its potential role in adaptive psychological processes.MethodsThis study combined a behavioral task, voxel‐based morphometry (VBM), and resting‐state functional connectivity (rsFC) analyses to investigate the neural substrates of the SI in a cohort of 145 participants, including young (n = 84), middle‐aged (n = 37), and older adults (n = 24).ResultsOur findings indicated that higher SI scores in older adults were correlated with greater gray matter volume in the right precuneus and stronger rsFC between the right precuneus and the left lateral occipital cortex. However, these correlations were not evident in younger and middle‐aged groups.ConclusionOur findings underscore the importance of the right precuneus and its connectivity in the manifestation of the SI, particularly in older adults, highlighting its potential role in adaptive aging processes.
Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways
Authors: Ryu Taekyung , Kim Kyungdo , Asiimwe Nicholas , Na Chan Hyun 
Published: January 2025

ABSTRACTAlzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation, neuroinflammation, RNA splicing, metabolic dysregulation, and cognitive resilience. This review examines recent proteomic findings from AD brain tissues and biological fluids, highlighting potential biomarkers and therapeutic targets. By examining the proteomic landscape of them, we aim to deepen our understanding of the disease and support developing precision medicine strategies for more effective interventions.