bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of structural and functional characteristics of the heart in patients after myocardial infarction with ST segment elevation as a marker of progression of chronic heart failure
Authors: Karetnikova V. N. , Berns S. A. , Shmidt E. A. , Artemova T. P. , Shepel R. N. , Barbarash O. L. 
Published: January 2023

Objective. To identify the association of a number of clinical features and structural and functional characteristics of the heart with the progression of chronic heart failure (CHF) in patients one year after ST-segment elevation myocardial infarction (MI) (STEMI) with preserved and reduced left ventricular ejection fraction (EF) (LVEF).Design and methods. 120 patients with STEMI were included in a prospective study. During the study, all patients underwent an echocardiographic study using a Sonos 2500 device (Hewlett Packard, USA) on the 1st day (point I), on the 12th day (point II) of hospitalization, and also after 1 year (point III). Depending on the parameters of EF on the 1st day of the disease, the total sample of patients was divided into two: the 1st group — with preserved LVEF was represented by 86 (71,7 %), the 2nd group — with a reduced LVEF was represented by 34 (28,3 %) patients.Results. A total of 19 (15,8 %) adverse events were registered. In two cases, a fatal outcome (1,7 %) was recorded, the cause of which was repeated MI, in five (4,2 %) patients decompensation of СHF was noted, in eight (6,7 %) patients a clinic of progressive angina was traced, in four (3, 3 %) of patients were diagnosed recurrent MI. Deterioration of systolic and diastolic function was established one year after STEMI with preserved (≥ 50 %) LVEF: 17,6 % of patients began to correspond to the intermediate range of EF (40-49 %), the number of patients with diastolic dysfunction increased by 10 % compared to with acute study.Conclusions. Within a year after a STEMI with initially preserved LVEF, there is a deterioration in myocardial function in the form of a decrease in myocardial contractility and an increase in the number of patients with diastolic dysfunction.
FusionPDB: a knowledgebase of human Fusion Proteins
Authors: Kumar Himansu , Tang Lin-Ya , Yang Chengyuan , Kim Pora 
Published: January 2023

Abstract

Tumorigenic functions due to the formation of fusion genes were targeted for cancer therapeutics (i.e., kinase inhibitors). However, many fusion proteins are still awaiting being targeted for therapeutics in diverse cellular working mechanisms. Due to the lack of whole fusion protein sequences and whole 3D structures of the fusion proteins, it was hard to develop novel therapeutic approaches. To fill these critical gaps, we developed a new computational pipeline and a resource of human fusion proteins named FusionPDB, available at https://compbio.uth.edu/FusionPDB. FusionPDB provides ~ 43K fusion protein sequences (of 14.7K in-frame fusion genes, Level 1), 2300 + 1267 fusion protein 3D structures (of 2300 recurrent + 266 manually curated in-frame fusion genes, Level 2), and virtual screening results of 1267 fusion proteins (of 266 manually curated in-frame fusion genes, Level 3). FusionPDB is the only resource providing whole 3D structures of fusion proteins and comprehensive knowledge of human fusion proteins. It will be regularly updated until covering all human fusion proteins in the future.
Wave function matching for the quantum many-body problem
Authors: Lee Dean , Elhatisari Serdar , Bovermann Lukas , Epelbaum Evgeny , Frame Dillon , Hildenbrand Fabian , Kim Myungkuk , Kim Youngman , Krebs Hermann , Lähde Timo , Li Ning , Lu Bing-Nan , Ma Yuanzhuo , Meissner Ulf-G. , Rupak Gautam , Shen Shihang , Song Young-Ho , Stellin Gianluca 
Published: January 2023

Abstract

We introduce a new approach for solving quantum many-body systems called wave function matching. Wave function matching transforms the interaction between particles so that the wave functions at short distances match that of an easily computable interaction. This allows for calculations of systems that would otherwise be impossible due to problems such as Monte Carlo sign cancellations. We apply the method to lattice Monte Carlo simulations of light nuclei, medium-mass nuclei, neutron matter, and nuclear matter. We use interactions at next-to-next-to-next-to-leading order in the framework of chiral effective field theory and find good agreement with empirical data. These results are accompanied by new insights on the nuclear interactions that may help to resolve long-standing challenges in accurately reproducing nuclear binding energies, charge radii, and nuclear matter saturation in ab initio calculations.
Young adults’ pathways of negating harms and pleasure related to recreational poly-drug use: A complex balancing act
Authors: Murray Hayley 
Published: January 2023

Abstract

Background: This paper examines the drug use and harm reduction practices of a subset of young adults in the Greater London area who engage in recreational poly-drug use. It traces their complex relationships with three popular party drugs – MDMA/ecstasy, cocaine, and alcohol – and explores the difficulties of balancing the harms and benefits within the context of situated poly-drug use practices.
Method: Longitudinal qualitative interviews with 31 young adults, aged 22 to 25. Three phases of thematic, semi-structured interviews were conducted from February 2018 to April 2019.
Results: This paper describes participants’ relationships to both MDMA and cocaine and the various ways they balance the risks and pleasures associated with these drugs. Participants appeared to succeed in balancing the two with MDMA, based largely on effective harm reduction messaging. With their cocaine use, however, we see a rise in challenges complicating this balancing act. Framed by ‘harm reduction from below,’ this paper shows that participants generally see cocaine’s adverse effects as less physically and mentally harmful than those of MDMA and this is reflected in their drug use choices. But the perception of cocaine’s relative safety has consequences, particularly when we consider the drug’s normalization and acceptability in spaces where it is frequently co-consumed with alcohol. In light of their consistent co-consumption of cocaine and alcohol, this pathway analysis suggests that participants’ efforts to reduce harm in one instance could create more harm and long-term negative effects in another. And as a result, participants struggle to bring the risk and pleasure of this co-consumption into balance.
Conclusion: Further exploration on both young peoples’ evolving motivations of drug choice and use and on how young people navigate the nuances of balancing acts within their poly-drug use would be a helpful contribution to advancing field of harm reduction. An emphasis on the psychological and physical risks of the prevalent practice of co-consuming cocaine and alcohol are also encouraged.
Understanding the Passive Behaviour of Low-Chromium High-Strength Hybrid Steel in Corrosive Environments
Authors: Örnek Cem , Payam Beste , Gloskovskii Andrei , Kazmanlı Kürşat , Derin Bora , Ürgen Mustafa , Avcı Burçak , Ooi Steve 
Published: January 2023

Abstract

We examined the unusual passive character of Hybrid steel in de-aerated sulfuric acid and aqueous sodium chloride solutions by benchmark corrosion and surface analytical tests in combination with CalPhaD-based thermochemical modelling. The electrochemical potentiodynamic polarization measurements have shown that Hybrid steel possesses all characteristic features of what makes steel stainless, such as passivity, breakdown and pitting, similar to standard low-alloyed stainless steel. Synchrotron hard X-ray photoelectron spectroscopy (HAXPES) analysis revealed that the stainless nature of Hybrid steel is achieved by a dynamically protective nanometre-sized passive film consisting of Fe, Cr, Ni, and Al oxides. The thermodynamic calculations showed that the surface oxide composition is Fe2O3•FeCr2O4•NiO•Al2O3, which changes structure, fraction and existence over electrochemical polarization. It has become understood that the presence of Al and Ni supports Cr in forming a spontaneously passive and hence protective surface, yielding exceptional corrosion resistance in acidic and chloride-containing aqueous solutions. The surface oxide could withstand breakdown and remain passive/repassivated even after transpassing the Cr(III)-to-Cr(VI) redox potential. While Cr is the prime passivating agent, an adverse effect of Cr was seen on grade 304 and 420 stainless steel when Cr(VI) species were released, savaging the passive film due to extensive interfacial pH reduction. However, among all tested stainless steels, Hybrid steel could repassivate due to the remaining and enriching Al and Ni oxides providing superior anodic passivation. Our work demonstrates that delicate alloying and microstructure engineering can design sustainable stainless steel with optimum high-strength properties without needing the well-known Cr threshold concentration of 10.5 per cent.
Astrocytoma and IDH1-Wildtype Glioblastoma (GBM) Cells Colonize Tumor Vessels and Deploy Vascular Mimicry
Authors: Maraqah Haitham H. , Abu-Asab Mones S. , Lee Han Sung , Aboud Orwa 
Published: January 2023

Abstract
Gliomas are the most prevalent type of malignant brain tumors with a very dismal prognosis. Angiogenesis in glioma has recently gotten more attention and its molecular aspects have been published; however, these were not complemented with ultrastructural evidence. Our ultrastructural examination of glioma vessels reveals several unique and critical features related to their mechanisms of progression and metastasis strategy. The detailed ultrastructural survey of 18 IDH1-wildtype glioblastomas (GBM) and 12 IDH1-mutant High-grade gliomas indicated that tumor vessels of both types had undergone deformities such as the thickening of the vessel wall (VW) and proliferation of the basement membrane, contour distortions, abnormal and discontinuous basal lamina, tumor cells’ invasion and colonization of VW, disappearance of endothelial cells (ECs), pericytes, and smooth muscle cells, as well as the formation of a continuous ring of tumor cells attached to the luminal side of VW in numerous cases. The latter feature is a clear sign of vascular mimicry (VM) that was previously suggested in gliomas but never shown by TEM. Additionally, the vascular invasion was carried out by a large number of tumor cells and was accompanied by the accumulation of tumor lipids in the vessels’ lumina and VWs; these two features are distinct for gliomas and may alter the course of the clinical presentation and overall prognosis. This raises the issue of how to specifically target tumor cells involved in vascular invasion in order to optimize prognosis and overcome these mechanisms employed by the tumor cells.
No lukewarm diatom communities - the response of freshwater benthic diatoms to phosphorus as basis for a new Phosphorus Diatom Index (PDISE)
Authors: Kahlert Maria , Fölster Jens , Tapolczai Kálmán 
Published: January 2023

Abstract

In the present study, we developed a new Swedish phosphorus diatom index (PDISE) to improve the poor fit of existing indices to match the needs of water managers to detect and mitigate eutrophication. We took advantage of a large amount of data (820 Swedish sites) collected in recent years. During our work, we found an unexpected bimodal response of the diatom taxa to phosphorus, with the taxa clustering into either an assemblage with a low, or with a high site-specific averaged optimum comprised of the diatom taxa optima. We could not find a characteristic diatom assemblage for sites with intermediate TP-site-specific averaged optima. To our knowledge, this bimodal community response has not been shown earlier. We found that the PDISE responded better than the currently used TDI and IPS to changes in TP concentrations, and thus should replace the TDI in the Swedish standard method. The modeled sensitivity values (expressed as categories) for TP were different compared to the TDI for most of the taxa included in the index development, indicating that the realized niche for these morphotaxa was different between Sweden and the UK where the TDI was developed originally. The correlation of the PDISE to TP was among the highest reported for other diatom nutrient indices globally, thus we believe that it might be worth to test it for other bioregions with similar geography and climate.
Low-loss Stable Storage of X-ray Free Electron Laser Pulses in a 14 m Rectangular Bragg Cavity
Authors: Margraf Rachel , Robles River , Halavanau Aliaksei , Krzywinski Jacek , Li Kenan , MacArthur James , Osaka Taito , Sakdinawat Anne , Sato Takahiro , Sun Yanwen , Tamasaku Kenji , Huang Zhirong , Marcus Gabriel , Zhu Diling 
Published: January 2023

Abstract
We present an experimental demonstration of a stable, low-loss, large x-ray cavity operating at 1.2 Angstrom wavelength. The cavity consists of 4 high reflectivity single crystal diamond Bragg mirrors arranged in a rectangular configuration with a design round trip distance of 14.2 m. Femtosecond x-ray laser pulses from an x-ray free electron laser were coupled into the cavity via a transmission phase grating. The cavity round trip efficiency and lifetime were characterized quantitatively, indicating close to the theoretical optical performance. By introducing focusing optics, we show that a stable cavity mode can be trapped within. The direct observation of sustained stable x-ray circulation provides the most direct evidence to date that cavity-based x-ray free electron lasers and other cavity-based hard x-ray systems are feasible.
Root aphid (Aploneura lentisci) population size on perennial ryegrass is determined by drought and endophyte strain
Authors: Hewitt Katrin G. , Hofmann Rainer W. , Ball Oliver J. , Cox Neil , Bryant Racheal H. , Finch Sarah C. , Popay Alison J. 
Published: January 2023

Abstract

Climate change is anticipated to lead to an increase in the occurrence and intensity of drought and fluctuations in insect cycles that will challenge modern pasture systems. Feeding by root aphids such as Aploneura lentisci Pass. can be a significant challenge to pastures. These below-ground living aphids are commonly found in New Zealand and Australia, feeding year-round on the roots of graminaceous plants such as perennial ryegrass (Lolium perenne L.). Some strains of the fungal endophyte Epichloë festucae var. lolii in perennial ryegrass can provide protection against root aphids and greater resilience under drought, contributing to higher persistency and growth than endophyte-free plants. However, the interaction between insect pressure and drought is not understood. This study examined the effect of drought on root aphid populations and plant performance in perennial ryegrass plants relative to endophyte status (+/-) and endophyte strain (AR37, NZCT) in a glasshouse experiment. Plants were cloned across the drought and well-watered treatments and half of the plants were inoculated with root aphids while half of the plants were treated with insecticide. Aphid populations were significantly higher in drought-stressed than in well-watered plants in both endophyte-infected and endophyte-free treatments. This resulted in reduced above and below ground plant growth. Our results suggest that root aphids are likely able to exploit the higher availability of amino acids in the plant sap of drought-exposed plants. This study provides evidence that climate change-mediated impacts of root aphids could reduce production in perennial ryegrass-dominant pastures. However, field trials would be necessary to determine whether this effect is seen in situ, where numerous additional factors will be operating at the same time.
Synthesis and Investigation of Superparamagnetic Nano-structured Fe3O4 (Magnetite) Powder Using Co-Precipitation Method
Authors: Saraçoğlu Mert , Bakırdöven Utku , Arpalı Handenur , Gezici Utku Orçun , Timur Servet 
Published: January 2023

Abstract
Superparamagnetic Fe3O4 nanoparticles have potential biomedical applications, but their synthesis can be challenging and costly. In this study, we present a simple and facile method for synthesizing these nanoparticles via the co-precipitation method. The pH and stabilizer concentration were optimized to obtain Fe3O4 nanoparticles with superparamagnetic characteristics and aggregated morphology in high purity. X-ray diffraction analysis revealed that the maximum magnetite formation was achieved at a pH of 12.5. Scanning electron microscopy (SEM) and vibrating sample magnetometry (VSM) were used to characterize the morphological and magnetic properties of the synthesized powders, respectively. The results showed that the synthesized particles were micrometer-sized, composed of nanoparticles ranging from 50 to 110 nm in size, and exhibited superparamagnetic behavior with a value of 40 emu/g. The superparamagnetic behavior was attributed to the presence of nanosized crystallites and nanoparticles in the aggregated structure rather than monodisperse particles. Overall, the co-precipitation method presented in this study offers an easy, non-toxic, and fast method for synthesizing Fe3O4 nanoparticles, which may be suitable for industrial-scale production.
Collective deliberation or just the state (in)action: how do we change the hydrodiplomacy landscape in South Asia?
Authors: Hazarika Natasha , Barua Anamika , Vij Sumit , Deka Arundhati , Salame Lena 
Published: January 2023

AbstractHydrodiplomacy in South Asia is in a nascent stage, primarily focusing on data exchange and limited state-to-state interactions, leaving aside an array of organic approaches to understand the facets of water diplomacy and governance. This perspective piece is based on a series of webinars to identify ways to bridge these gaps in hydrodiplomacy in South Asia, highlighting the merit of multi-track diplomacy for embracing the plurality of interests and decision-making. The piece concludes that it is pertinent to build capacities for improving science-media communication, acknowledging and strategizing power asymmetry, and implementing international water law to guide water diplomacy.
Groundwater quality assessment using the WQI and GIS mapping: Suitability for drinking and irrigation usage in the Sirdala block of Nawada district
Authors: Kumar Abhishek , Maurya Nityanand Singh 
Published: January 2023

Abstract
In the present study, the suitability of groundwater for drinking and irrigation purpose were analyzed. A total of 65 groundwater samples were collected and analyzed for relevant water quality parameters from Sirdala block of Nawada district Bihar (India). To estimate the WQI for the drinking purpose, various parameters such as pH, TDS, TH, AS and major ions (Ca2+, Mg2+, Na+, K+, Cl−, F−, HCO3−, NO3−, SO42−) were considered. The WQI for irrigation, various irrigation indices namely soluble sodium percent (Na%), sodium adsorption ratio (SAR), residual sodium bicarbonate (RSCB), permeability index (PI), magnesium hazards ratio (MHR), Kelly's ratio (KR), potential salinity (PS), Cl−: HCO3−, Mg(2+): Ca(2+) and Na+: Ca(2+) were employed and discussed in addition with Wilcox and USSL diagram. Plots, namely Gibbs ratio and Piper diagram, were used to understand chemical characteristics of groundwater. The WQI for drinking purpose was observed between 57.67 and 929.90 in which most samples (70.76%) were unsuitable for drinking. However, the WQI for irrigation purpose varied from 87.88 to 434.67 in which 50% of samples were suitable. Gibb's plots determined in this study reveal that evaporation-precipitation was the dominant factor that influences hydrochemistry. Piper plots suggest that Na-HCO3− water type was major hydrochemical facies in groundwater.
Determination of pollution status of Nilüfer river by water and bottom sediment analysis
Authors: Aşik Barış Bülent , Özsoy Gökhan 
Published: January 2023

Abstract
This study aims to evaluate the Nilüfer river in terms of water quality standards. Bottom sediment and water samples were taken from six different locations. The analysis of the physicochemical parameters of water compared with FAO for irrigation water quality standards. In addition, the SAR (sodium adsorption ratio), % Na, MAR (magnesium adsorption ratio), RSC (residual sodium carbonate), KR (Kelley's ratio) and % PI (permeability index) parameters were evaluated in water samples. The bottom sediment pollution situation was evaluated in terms of pollution index such as TEC (threshold effect concentration) and PEC (probable effect concentration). According to the results of the study, the irrigation water classes of the samples were determined as C2S1 and C3S1. Especially, sample sites S4, S5 and S6 were not suitable for irrigation in terms of RSC, KR. The bottom sediment exceeded the TEC and PEC limit values in terms of Zn, Cu, Cr and Ni contents. This may cause adverse effects on the majority of sediment-dwelling organisms.The use of alternative water sources should be preferred. The river can be used for irrigation with precaution but extensive treatment is required before use for irrigation purposes to prevent adverse public health effects.
Determinants Influencing the Adoption of Internet Health Care Technology Among Chinese Health Care Professionals: Extension of the Value-Based Adoption Model With Burnout Theory
Authors: Bian Dongsheng , Xiao Yuyin , Song Keyu , Dong Minye , Li Li , Millar Ross , Shi Chenshu , Li Guohong 
Published: January 2023

Background
The global COVID-19 pandemic has been widely regarded as a catalyst for adopting internet health care technology (IHT) in China. IHT consists of new health care technologies that are shaping health services and medical consultations. Health care professionals play a substantial role in the adoption of any IHT, but the consequences of doing so can often be challenging, particularly when employee burnout is prevalent. Few studies have explored whether employee burnout influences the adoption intention of IHT in health care professionals.

Objective
This study aims to explain the determinants influencing the adoption of IHT from the perspective of health care professionals. To do so, the study extends the value-based adoption model (VAM) with consideration for employee burnout as a determining factor.

Methods
A cross-sectional web-based survey using a sample of 12,031 health care professionals selected through multistage cluster sampling from 3 provinces in mainland China was conducted. The hypotheses of our research model were developed based on the VAM and employee burnout theory. Structural equation modeling was then used to test the research hypotheses.

Results
The results indicate that perceived usefulness, perceived enjoyment, and perceived complexity positively correlate with perceived value (β=.131, P=.01; β=.638, P<.001; β=.198, P<.001, respectively). Perceived value had a positive direct effect on adoption intention (β=.725, P<.001), perceived risk negatively correlated with perceived value (β=−.083, P<.001), and perceived value negatively correlated with employee burnout (β=−.308, P<.001). In addition, employee burnout was negatively related to adoption intention (β=−.170, P<.001) and mediated the relationship between perceived value and adoption intention (β=.052, P<.001).

Conclusions
Perceived value, perceived enjoyment, and employee burnout were the most important determinants of IHT adoption intention by health care professionals. In addition, while employee burnout was negatively related to adoption intention, perceived value inhibited employee burnout. Therefore, this study finds that it is necessary to develop strategies to improve the perceived value and reduce employee burnout, which will benefit the promotion of the adoption intention of IHT in health care professionals. This study supports the use of the VAM and employee burnout in explaining health care professionals’ adoption intention regarding IHT.