bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Point-based Model for Poor Academic Performance in Japanese University Students Based on Lifestyle Risk Factors: A Prospective Cohort Study
Authors: Chu Tianshu , Chen Tao , Saito Takafumi , Takayanagi Shigemi , Fukumori Hideaki , Masaki Yoshinori , Kumagai Shuzo , Kishimoto Hiro 
Published: February 2023

Aims: Multiple lifestyle behaviors have been linked with poor academic performance (AP) in undergraduate students. It is unknown whether a risk prediction model that incorporates a combination of different lifestyle behaviors would predict the risk of poor AP.
Study design: a population-based prospective study
Methods: A total of 2,282 eligible participants (men: 66%) aged 18 to 22 years were followed up for four years. Poor AP was defined as a grade point average (GPA) of less than 2.0. Cox proportional hazards models were used to identify lifestyle behaviors associated with the development of poor AP, and a score was created from predictors in the final model.
Results: During a median follow-up period of four years, 440 (29.2%) men and 111 (14.3%) women developed poor AP. The final model for poor AP in men included low frequency of breakfast intake, dietary intake ups and downs, shorter weekday study time, longer weekday video game time, doing exercise almost every day, self-rated irregular lifestyle. In women, alcohol intake once or more per week, low frequency of breakfast intake, dietary intake ups and downs were included in the final model for poor AP. The risk prediction models showed good discriminatory abilities (C statistics: 0.73, 95% confidence interval [CI]: 0.67, 0.78 for women; and 0.70, 95% CI: 0.66, 0.74 for men).
Conclusions: This risk prediction model incorporating multiple unhealthy lifestyle behaviors predicts poor AP with good discrimination ability.
Cow Urine Extract of Nicotiana tabacum Leaf Portends Hepatotoxicity in Male Wistar Rats
Authors: Ola Yusuf Babalola , Yusuf Lukman Halimat , Okeme Usman , Ibrahim Ganiyu Aderounmu , Oyewole Salawu Musa , Adeola Moronfolu Ibrahim , Suleiman Olakunle Olanrewaju , Bello Abdulfatah Lateefat , Azeezat Aiwinnilomo Motunrayo , Bolaji Ibrahim Rasheed , Titilola Abdulazeez Azeemat , Oyelola Bukoye Oloyede Hussein 
Published: February 2023

Aims: The toxicological effects of single and repeated doses of aqueous extract (AE) and cow urine extract (CUE) of Nicotiana tabacum leaf on the liver and kidney function indices of male Wistar rats were investigated.
Study Design: Thirty-five male rats were randomized into seven groups (n=5). The control group received 0.5 mL of distilled water, groups A and B received 8 mg/kg body weight (BW) of CUE and AE respectively, once daily; groups C and D received 16 mg/kg BW of CUE and AE respectively, thrice a day (TD); groups E and F received 32 mg/kg BW of CUE and AE respectively, TD.The administration was oral and lasted for 28 days.
Place and Duration of Study: The study was carried out at Summit University, Offa, Nigeria between June 2019 and August 2019.
Methodology: Thirty-five male rats were randomized into seven groups (n=5). The control group received 0.5 mL of distilled water, groups A and B received 8 mg/kg body weight (BW) of CUE and AE respectively, once daily; groups C and D received 16 mg/kg BW of CUE and AE respectively, thrice a day (TD); groups E and F received 32 mg/kg BW of CUE and AE respectively, TD.
Results: The result revealed no significant difference in the activities of the ALP, and GGT but a significant increase in the ACP, ALT, and AST activities in both tissues and serum. Furthermore, there was a significant decrease in albumin concentration of rats in all the groups except group B when compared with the control rats. Liver and kidney histology revealed minimal lymphocytic infiltration with no sign of medium-term systemic damage.
Conclusion: The study suggests no nephrotoxicity of AE and CUE at all doses administered, but probable hepatotoxicity at higher and repeated doses of both extracts except at the single dose of 8 mg/kg BW of AE.
The Incidence of Multirsistance Kocuria spp. among Different Clinical Samples in Erbil City, Iraq
Authors: Ali Fattma A. , Al-Daood Ahmed Akil Khudhair , Burhan Padasht Kamil , Tofiq Lava Rasul , Shakur Payam Samir 
Published: February 2023

Background: Gram positive Kocuria spp. are a part of normal of the skin and oropharynx commensals in mammals but also described as opportunistic pathogens in human infections including urinary tract infection, pneumonia, wound infection, Ear infection, bronchial infection and also peritonitis and brain abscess, isolated from different clinical specimens increasing resistance to some antibiotics all over the world by distribution between patient with high morbidity and mortality rates.
Objective: Our study aimed to carry out retrospective study on Kocuria spp. isolated from various clinical samples in Erbil city and analyzed its epidemiology, antibiotic resistance pattern and pathogenic potential.
Methods: A total of thirty Kocuria spp. isolated distributed according to their source of isolation such as blood, wound, CSF, ear swab, throat swab, ascetic fluid and bronchial wash isolated and identified by using microscopical, morphological, biochemical tests and API and Vitek 2 compact system. Antibiotic susceptibility test was performed by manually by using 8 antibiotics (Ciprofloxacin, Gentamicin, Amikacin, Nitrofurantion, Cefotaxime, Ceftriaxone, Cifixime, Amoxicillin-Clavulanate (2:1)). Phenotypic screening of ESBLs was undertaken using Vitek 2 compact system.
Results: Out of 4399 samples, 30 samples were tested positive for Kocuria spp., the highest percentage of Kocuria spp. In female 20(0.76%) was higher than those in male patients 10(0.57%) Results showed that 30 isolates of Kocuria distributed as (13) isolates were indicated as Kocuria kristinae, (5) Kocuria varians, and (6) Kocuria rosea Kocuria spp.isolates showed high resistance (43.3%) to Cifixime, (30%) to Amoxicillin-Clavulanate 2:1, (26.7%) to Amikacin, (20%) to Nitrofurantion and (13.3%) to both Gentamicin and Cefotaxime. Kocuria spp. was surprisingly (100%) sensitive to Ciprofloxacin and Ceftriaxone with all the 30 samples that we had. Relation between bacteria species and gender, all species showed higher number in female than male.
Sensitivity and Specificity of the Modified Checklist for Autism in Toddlers (Original and Revised)
Authors: Wieckowski Andrea Trubanova , Williams Lashae N. , Rando Juliette , Lyall Kristen , Robins Diana L. 
Published: February 2023

ImportanceThe Modified Checklist for Autism in Toddlers (M-CHAT) and the M-CHAT, Revised With Follow-up (M-CHAT-R/F)—henceforth referred to as M-CHAT(-R/F)—are the most commonly used toddler screeners for autism spectrum disorder (ASD). Their use often differs from that in the original validation studies, resulting in a range of estimates of sensitivity and specificity. Also, given the variability in reports of the clinical utility of the M-CHAT(-R/F), researchers and practitioners lack guidance to inform autism screening protocols.ObjectiveTo synthesize variability in sensitivity and specificity of M-CHAT(-R/F) across multiple factors, including procedures for identifying missed cases, likelihood level, screening age, and single compared with repeated screenings.Data SourcesA literature search was conducted with PubMed, Web of Science, and Scopus to identify studies published between January 1, 2001, and August 31, 2022.Study SelectionArticles were included if the studies used the M-CHAT(-R/F) (ie, original or revised version) to identify new ASD cases, were published in English-language peer-reviewed journals, included at least 10 ASD cases, reported procedures for false-negative case identification, screened children by 48 months, and included information (or had information provided by authors when contacted) needed to conduct the meta-analysis.Data Extraction and SynthesisThe systematic review and meta-analysis was conducted within the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. The Quality Assessment of Diagnostic Accuracy Studies–2 tool evaluated bias in sample selection. Data extraction and quality assessment were performed by 2 authors independently. The overall diagnostic accuracy of the M-CHAT(-R/F) was assessed with the hierarchic summary receiver operating characteristic (HSROC) model.Main Outcomes and MeasuresSensitivity, specificity, diagnostic odds ratios, and HSROC curves of M-CHAT(-R/F).ResultsThe review included 50 studies with 51 samples. The pooled sensitivity of M-CHAT(-R/F) was 0.83 (95% CI, 0.77-0.88), and the pooled specificity was 0.94 (95% CI, 0.89-0.97). Heterogeneity analyses revealed greater diagnostic accuracy for low- vs high-likelihood samples, a concurrent vs prospective case confirmation strategy, a large vs small sample size, use of M-CHAT(-R/F) Follow-up, and non-English vs English only.Conclusions and RelevanceOverall, results of this study suggest the utility of the M-CHAT(-R/F) as an ASD screener. The wide variability in psychometric properties of M-CHAT(-R/F) highlights differences in screener use that should be considered in research and practice.
Multicomponent Intermetallic Nanoparticles on Hierarchical Metal Network as Versatile Electrocatalysts for Highly Efficient Water Splitting
Authors: Shi Hang , Sun Xin‐Ying , Liu Yang , Zeng Shu‐Pei , Zhang Qing‐Hua , Gu Lin , Wang Tong‐Hui , Han Gao‐Feng , Wen Zi , Fang Qian‐Rong , Lang Xing‐You , Jiang Qing 
Published: February 2023

AbstractDeveloping high‐efficiency and cost‐effective alloy catalysts toward hydrogen‐evolution reaction (HER) is crucial for large‐scale hydrogen production via electrochemical water splitting, but conventional single‐principal‐element alloy design usually causes insufficient activity and durability of state‐of‐the‐art multimetallic catalysts based on non‐precious transition metals. Herein, we report multicomponent intermetallic Mo(NiFeCo)4 nanoparticles seamlessly integrated on hierarchical nickel network (Mo(NiFeCo)4/Ni) as robust hydrogen‐evolution electrocatalysts with remarkably improved activity and durability by making use of iron and cobalt atoms partially substituting nickel sites to form high‐entropy NiFeCo sublattice in intermetallic MoNi4 matrix, which serve as bifunctional electroactive sites for both water dissociation and adsorption/combination of hydrogen intermediate and improves thermodynamic stability. By virtue of bicontinuous nanoporous nickel skeleton facilitating electron/ion transportation, self‐supported nanoporous Mo(NiFeCo)4/Ni electrode exhibits exceptional HER electrocatalysis, with low Tafel slope (≈35 mV dec−1), high current density (≈2300 mA cm−2) at low overpotential (200 mV) and long‐term durability in 1 m KOH. When coupled to its electrooxidized and nitrified derivative for oxygen‐evolution reaction, their alkaline water electrolyzers operate with a superior overall water‐splitting output, outperforming the one constructed with commercially available noble‐metal‐based catalysts. These electrochemical properties make it an attractive candidate as electrocatalyst in alkaline water electrolysis for large‐scale hydrogen generation.
Highly Efficient Top‐Emitting Infrared‐to‐Visible Up‐Conversion Device Enabled by Microcavity Effect
Authors: Kim Ji Hun , Lee Jong‐Yun , Lim Chanwoo , Roh Jiho , Baek Se‐Woong , Kim Woong , Suh Min Chul , Yu Hyeonggeun 
Published: February 2023

AbstractInfrared (IR)‐to‐visible up‐conversion device allows a low‐cost, pixel‐free IR imaging over the conventional expensive compound semiconductor‐based IR image sensors. However, the external quantum efficiency has been low due to the integration of an IR photodetector and a light‐emitting diode (LED). Herein, by inducing a strong micro‐cavity effect, a highly efficient top‐emitting IR‐to‐visible up‐conversion device is demonstrated where PbS quantum dots IR‐absorbing layer is integrated with a phosphorescent organic LED. By optimizing the optical cavity length between indium tin oxide (ITO)/thin Ag/ITO anode and semi‐transparent Mg:Ag top cathode, the up‐conversion device yields 15.7% of photon‐to‐photon conversion efficiency from the top‐emission. The high efficiency can be achieved under a low IR transmission through the semi‐reflective anode. Finally, pixel‐free IR imaging is demonstrated using the up‐conversion device, boosting the effect of micro‐cavity on the brightness and the contrast of an IR image.
Digitization of Free‐Shapable Graphene Foam with Damage Tolerance
Authors: Xu Xi , Du Junjie , Cao Qinghe , Zhang Danwei , Li Chen , Fu Gangwen , Gao Yong , Yang Jiayu , Guan Cao , Huang Wei 
Published: February 2023

Abstract3D construction of 2D sheets is the key to the utilization of graphene for large scale industrial applications. The layer by layer approach of additive manufacturing enables a high degree of design freedom for the fabrication of 3D graphene structures with excellent mechanical flexibility. Herein, the excellent mechanical and functional properties of 3D nitrogen‐doped graphene (NG) foams fabricated is demonstrated via 3D printed templates and template‐directed chemical vapor deposition. The super‐elastic foam, consisting of interconnected networks of graphene sheets can make near complete strain recovery from load up to 62500 times its own weight, with extraordinary damage tolerance at a low density of 9.5 mg cm−3. Fast transport of charge carriers (5 S cm−1) highlights the potential of the NG foam for use in various functional applications. Observed temperature‐invariant reversible elasticity from −196 to 300 °C further emphasizes its value for use in demanding environments.
A Superconducting Micro‐Magnetometer for Quantum Vortex in Superconducting Nanoflakes
Authors: Bi Xiangyu , Tian Feifan , Chen Ganyu , Li Zeya , Qin Feng , Lv Yang‐Yang , Huang Junwei , Qiu Caiyu , Ao Lingyi , Chen Yanbin , Gu Genda , Chen Yanfeng , Yuan Hongtao 
Published: February 2023

AbstractSuperconducting quantum interferometer device (SQUID) plays a key role in understanding electromagnetic properties and emergent phenomena in quantum materials. The technological appeal of SQUID is that its detection accuracy for the electromagnetic signal can precisely reach the quantum level of a single magnetic flux. However, conventional SQUID techniques normally can only be applied to a bulky sample and do not have the capability to probe the magnetic properties of micro‐scale samples with small magnetic signals. Herein, it is demonstrated that, based on a specially designed superconducting nano‐hole array, the contactless detection of magnetic properties and quantized vortices in micro‐sized superconducting nanoflakes is realized. An anomalous hysteresis loop and a suppression of Little–Parks oscillation are observed in the detected magnetoresistance signal, which originates from the disordered distribution of the pinned vortices in Bi2Sr2CaCu2O8+δ. Therefore, the density of pinning centers of the quantized vortices on such micro‐sized superconducting samples can be quantitatively evaluated, which is technically inaccessible for conventional SQUID detection. The superconducting micro‐magnetometer provides a new approach to exploring mesoscopic electromagnetic phenomena of quantum materials.
Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle‐Based Biosensors
Authors: Saifullah Khaled Mohammed , Faraji Rad Zahra 
Published: February 2023

AbstractAlthough interstitial fluid (ISF) is recognized as an important source of biomarkers, it is difficult and time‐consuming to extract, thus limiting its use in medical diagnostic and clinical settings. An inexpensive and effective technique for accessing ISF could benefit people with various health conditions and offer platforms for on‐device sensing biomarkers. Microneedles (MNs) are minimally invasive devices that have gained extensive interest over recent decades. MNs can address some of the challenges associated with ISF extraction and sensing. Accessing ISF using MNs has the potential to develop advanced, non‐invasive point‐of‐care (POC) microdevices that enable detection or continuous monitoring within the dermal ISF, therefore drastically impacting the healthcare system. This review describes recent studies exploring MN devices for ISF sampling and sensing. Several extraction processes, sampling volume, sampling duration, integration with biosensors, sensing of biomarkers, and subsequent analysis of ISF are discussed in detail. Furthermore, opportunities, conclusions, and future prospects for developing new research in the field are also discussed.
Application of Lignin‐Derived Graphene Quantum Dots in Visible Light‐Driven Photoelectrochemical Photodetector
Authors: Wang Ruibin , Su Wenjie , Zhang Shilong , Jin Linghua , Zhang Jing , Bian Huiyang , Zhang Ye 
Published: February 2023

AbstractGraphene quantum dots are the latest addition to the low‐dimensional nanomaterial family, which have drawn growing attention due to their unique physiochemical properties and potential applications in many fields. However, their practical application is hindered by the high fabrication cost and environmental concerns regarding unsustainable carbon sources and routes. This work demonstrates a universal approach to fabricate various heteroatom(s) doped lignin‐derived graphene quantum dots (LGQDs) for utilization in the photoelectrochemical‐type photodetectors (PDs). The results indicate that LGQDs are endowed with relatively dopant‐rich chemical states and tailorable broadband photoluminescence. Based on these advantages, these novel LGQDs‐based PDs present obvious and fast photo‐response within the visible region, as well as good long‐term stability in the mild neutral environment, suggesting their great practical significance. It is believed that this work paves a new way for developing PDs based on the photochemically active species from sustainable and cheap biomass‐derived lignin.
Regioisomeric Engineering to Optimize the Characteristics of TADF Emitters for High‐Performance Solution Processable Organic Light Emitting Diodes
Authors: Zhao Guimin , Zhou Renyin , Zhang Guanghao , Chen Haowen , Wang Xinjian , Zhang Zhengmao , Tian Wenwen , Jiang Wei , Sun Yueming 
Published: February 2023

AbstractNimble utilization of the regioisomerism concept plays an important role in organic optoelectronic field to exploit high‐performance materials in a concise way. However, the relationship between the binding mode and molecular property is still short of explicit understanding and it impedes the creation of desirable materials efficiently. Herein, we report three regioisomeric emitters with obvious thermally activated delayed fluorescence (TADF) and aggregation‐induced emission characteristics when multiple flexible dendrons are bonded to the different substituted position of carbazole groups (C2/C3/C4) through ether bond. Bonding positions are closely correlated with molecular electrostatic potential, emissive wavelength, reverse intersystem crossing process, and exciton utilization efficiency. Fully solution processable organic light emitting diodes manifest the otherness of these isomers in device performance, and highlight the significant status of these regioisomers not only acting as non‐doped emitter but also functioning as TADF sensitizer in a multi‐resonance system, which show a maximum external quantum efficiency of 20.8% and a narrow full width at half maximum of 29 nm.
Hypoxia‐Induced FUS–circTBC1D14 Stress Granules Promote Autophagy in TNBC
Authors: Liu Ying , Liu Yiwei , He Yinqiao , Zhang Ning , Zhang Siyue , Li Yaming , Wang Xiaolong , Liang Yiran , Chen Xi , Zhao Weijing , Chen Bing , Wang Lijuan , Luo Dan , Yang Qifeng 
Published: February 2023

AbstractTriple‐negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that is suggested to be associated with hypoxia. This study is the first to identify a novel circular RNA (circRNA), circTBC1D14, whose expression is significantly upregulated in TNBC. The authors confirm that high circTBC1D14 expression is associated with a poor prognosis in patients with breast cancer. circTBC1D14‐associated mass spectrometry and RNA‐binding protein‐related bioinformatics strategies indicate that FUS can interact with circTBC1D14, which can bind to the downstream flanking sequence of circTBC1D14 to induce cyclization. FUS is an essential biomarker associated with stress granules (SGs), and the authors find that hypoxic conditions can induce FUS–circTBC1D14‐associated SG formation in the cytoplasm after modification by protein PRMT1. Subsequently, circTBC1D14 increases the stability of PRMT1 by inhibiting its K48‐regulated polyubiquitination, leading to the upregulation of PRMT1 expression. In addition, FUS–circTBC1D14 SGs can initiate a cascade of SG‐linked proteins to recognize and control the elimination of SGs by recruiting LAMP1 and enhancing lysosome‐associated autophagy flux, thus contributing to the maintenance of cellular homeostasis and promoting tumor progression in TNBC. Overall, these findings reveal that circTBC1D14 is a potential prognostic indicator that can serve as a therapeutic target for TNBC treatment.
Advanced Soft Robotic System for In Situ 3D Bioprinting and Endoscopic Surgery
Authors: Thai Mai Thanh , Phan Phuoc Thien , Tran Hien Anh , Nguyen Chi Cong , Hoang Trung Thien , Davies James , Rnjak‐Kovacina Jelena , Phan Hoang‐Phuong , Lovell Nigel Hamilton , Do Thanh Nho 
Published: February 2023

AbstractThree‐dimensional (3D) bioprinting technology offers great potential in the treatment of tissue and organ damage. Conventional approaches generally rely on a large form factor desktop bioprinter to create in vitro 3D living constructs before introducing them into the patient's body, which poses several drawbacks such as surface mismatches, structure damage, and high contamination along with tissue injury due to transport and large open‐field surgery. In situ bioprinting inside a living body is a potentially transformational solution as the body serves as an excellent bioreactor. This work introduces a multifunctional and flexible in situ 3D bioprinter (F3DB), which features a high degree of freedom soft printing head integrated into a flexible robotic arm to deliver multilayered biomaterials to internal organs/tissues. The device has a master‐slave architecture and is operated by a kinematic inversion model and learning‐based controllers. The 3D printing capabilities with different patterns, surfaces, and on a colon phantom are also tested with different composite hydrogels and biomaterials. The F3DB capability to perform endoscopic surgery is further demonstrated with fresh porcine tissue. The new system is expected to bridge a gap in the field of in situ bioprinting and support the future development of advanced endoscopic surgical robots.