bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics and tolerability of the maturation inhibitor GSK3640254 coadministered with darunavir/ritonavir and/or etravirine in healthy adults
Authors: Zhang Ying , Joshi Samit , Yazdani Parto , Zhan Joyce , Wen Bo , Bainbridge Veronica , Ballesteros‐Perez Alex , Gartland Martin , Lataillade Max 
Published: August 2023

AimsThis phase I study investigated potential drug–drug interactions of the maturation inhibitor GSK3640254 (GSK'254) with darunavir/ritonavir (DRV/RTV) and/or etravirine (ETR).MethodsIn this randomized, open‐label, single‐sequence, multiple‐dose study, healthy participants received GSK'254 200 mg once daily alone or coadministered with DRV/RTV 600/100 mg twice daily (BID; n = 19), ETR 200 mg BID (n = 19) or DRV/RTV 600/100 mg + ETR 200 mg BID (n = 16) under fed conditions. Primary endpoints were steady‐state area under the plasma concentration–time curve from time 0 to the end of the dosing interval (AUC0‐τ) and maximum observed concentration (Cmax). Secondary endpoints included trough concentration (Cτ), safety and tolerability. Pharmacokinetic parameters were calculated using standard noncompartmental analysis, and geometric least‐squares mean ratios were derived from linear mixed‐effects models.ResultsGSK'254 AUC0‐τ (geometric least‐squares mean ratio [90% confidence interval], 1.14 [1.00–1.29]), Cmax (1.07 [0.92–1.24]) and Cτ (1.17 [1.01–1.35]) were similar when administered alone and with DRV/RTV. Etravirine coadministration decreased GSK'254 AUC0‐τ (0.53 [0.48–0.59]), Cmax (0.60 [0.53–0.68]) and Cτ (0.51 [0.39–0.66]). Similar reductions were not observed with GSK'254 + DRV/RTV + ETR (AUC0‐τ, 0.94 [0.82–1.09]; Cmax, 0.89 [0.75–1.07]; Cτ, 1.02 [0.89–1.18]). GSK'254 had no meaningful effect on DRV/RTV or ETR concentrations. All reported adverse events (AEs) were grade 1; 3 led to withdrawal and resolved (rash, asymptomatic electrocardiogram T‐wave inversion, periorbital oedema). Most common AEs were diarrhoea (n = 9) and headache (n = 7). No deaths or serious AEs occurred.ConclusionGSK'254 pharmacokinetics was not meaningfully affected by DRV/RTV or DRV/RTV + ETR, but were reduced with only ETR; no new tolerability concerns were observed.
ChatGPT in pharmacometrics? Potential opportunities and limitations
Authors: Cloesmeijer Michael E. , Janssen Alexander , Koopman Sjoerd F. , Cnossen Marjon H. , Mathôt Ron A. A. ,   for the SYMPHONY consortium
Published: August 2023

AbstractThe potential of using ChatGPT in pharmacometrics was explored in this study, with a focus on developing a population pharmacokinetic (PK) model for standard half‐life factor VIII. Our results demonstrated that ChatGPT can be utilized to accurately obtain typical PK parameters from literature, generate a population PK model in R and develop an interactive Shiny application to visualize the results. ChatGPT's language generation capabilities enabled the development of R codes with minimal programming knowledge and helped to identify as well fix errors in the code. While ChatGPT presents several advantages, such as its ability to streamline the development process, its use in pharmacometrics also has limitations and challenges, including the accuracy and reliability of AI‐generated data, the lack of transparency and reproducibility regarding codes generated by ChatGPT. Overall, our study demonstrates the potential of using ChatGPT in pharmacometrics, but researchers must carefully evaluate its use for their specific needs.
Thyroid function test abnormalities‐isolated TPOAb+, SCH and hypothyroxinemia and preschool children's neurodevelopment
Authors: Zhu Linlin , Teng Yuzhu , Guo Yufan , Ru Xue , Wu Xiaoyan , Hao Jiahu , Tao Fangbiao , Huang Kun 
Published: August 2023

AbstractObjectiveThyroid function test abnormalities are frequent and associated with the offspring's adverse neurodevelopment. This study aimed to examine the relationship between maternal thyroid function test abnormalities before 20 gestational weeks and children's cognitive, emotional and behavioural development at 3–6 years of age.Patients and MeasurementsA total of 2243 mother–child pairs were included in the final analysis. Maternal thyroid function was evaluated retrospectively during the children's preschool period. The serum thyrotrophin, free thyroxine and thyroid peroxidase antibodies (TPOAb) were detected by chemiluminescence immunoassay during the follow‐up period. The neurodevelopmental status of preschoolers aged 3–6 years was evaluated by parental versions of The Behavior Rating Inventory of Executive Function‐Preschool and The Strengths and Difficulties Questionnaires. The associations between maternal thyroid function test abnormalities and preschoolers' neurodevelopment were examined using Poisson regression models.ResultsAfter adjusting for potential confounders in Poisson regression analyses, it showed that maternal isolated TPOAb positivity before 20 gestational weeks may be associated with the increased risk of abnormalities in peer problems (odds ratio [OR] = 1.90, 95% confidence interval [CI]: 1.26, 287). Maternal isolated SCH before 20 gestational weeks was observed to be related with increased risk of abnormalities in inhibition (OR = 2.73, 95% CI: 1.37, 5.41), working memory (OR = 1.67, 95% CI: 1.04, 2.70), conduct problems (OR = 1.80, 95% CI: 1.05, 3.09), hyperactivity (OR = 1.94, 95% CI:1.08, 3.49) and total difficulties (OR = 1.94, 95% CI: 1.13, 3.34). Maternal isolated hypothyroxinemia before 20 gestational was observed to be related with increased risk of abnormalities in peer problems (OR = 2.71, 95% CI: 1.17, 6.27).ConclusionsThyroid function test abnormalities before 20 gestational weeks may be associated with children's neurodevelopment at 3–6 years of age.
Saikosaponin D attenuates inflammatory response and cell apoptosis of lipopolysaccharide‐induced lung epithelial cells
Authors: Song Lijie , Lu Guoyu , Tao Yanyan 
Published: August 2023

AbstractBackgroundAcute lung injury (ALI) is a prevalent complication of sepsis with high mortality rate. Saikosaponin D (SSD) is a triterpenoid saponin that has been reported to alleviate sepsis‐triggered renal injury in mice. Nonetheless, the therapeutic effect of SSD on sepsis‐evoked ALI is unclarified.MethodsLipopolysaccharide (LPS) from Escherichia coli 055:B5 was utilized to stimulate lung epithelial cell line MLE‐12. A mouse model of sepsis was established. CCK‐8 assay was employed for determining cytotoxicity. ELISA was utilized for determining proinflammatory cytokine production. Flow cytometry and western blotting were implemented for evaluating cell apoptosis. Hematoxylin–eosin staining was conducted for histologic analysis of murine lung tissues.ResultsSSD alleviated LPS‐triggered inflammation and cell apoptosis of MLE‐12 cells. SSD treatment ameliorated the pathological damages, inflammatory response, and cell apoptosis in the lungs of septic mice.ConclusionSSD protects against sepsis‐triggered ALI by inhibiting inflammation and cell apoptosis in MLE‐12 cells and septic mouse mice.
Which metrics derived from airborne laser scanning are essential to measure the vertical profile of ecosystems?
Authors: Kissling W. Daniel , Shi Yifang 
Published: August 2023

AbstractIn a recent perspective (Diversity and Distributions, 29, 39–50), ‘10 variables’ were proposed to measure vegetation structure from airborne laser scanning (ALS) for assessing species distributions and habitat suitability. We worry about this list because the variables predominantly represent variation in vegetation height, the vertical variability of vegetation biomass is insufficiently captured, and variables of vegetation cover are ill‐defined or not ecosystem agnostic. We urge for a better defined, more comprehensive and more balanced list, and for assessing which information from ALS point clouds is truly essential to measure the major dimensions of 3D vegetation structure within and across ecosystems and animal habitats. We think that the currently proposed ‘list of 10 ALS metrics’ is premature and that researchers and stakeholders should be cautious in adopting this list.
News sentiment and investment efficiency: Evidence from China
Authors: Hsu Yuan‐Teng , Hua Min , Liu Heng , Wang Qingren 
Published: August 2023

AbstractThis study investigates the impact of media sentiment on firms' investment efficiency in the Chinese market during 2007–2017. We find that increased media sentiment can lead to overinvestment and thus distort investment efficiency, but it has no significant effect on underinvestment. Further, mediation analysis shows that financing constraints mediates the media sentiment effects on overinvestment. To mitigate potential endogenous problems, we employ instrumental variable approach and propensity score matching method. The main findings hold after a battery of robustness tests. Further tests show that corporate governance factors can ameliorate the adverse effect of news sentiment on corporate investment efficiency.
PooRaa‐Agri KG: An agricultural knowledge graph‐based simplified multilingual query system
Authors: Sivakumar Nethraa , Srinivasan Pooja , Kannan Mrinalini , P Vijayalakshmi , T Nagarajan 
Published: August 2023

AbstractThe current work proposes PooRaa‐Agri KG, an agricultural knowledge graph‐based simplified multilingual query system that works in real time to provide concise answers for agriculture‐based queries. The proposed approach accommodates real‐time and low‐resource queries in English and Hindi with a novel multi‐stage solution consisting of data pre‐processing, sentence simplification, triplet extraction, knowledge graph generation, sentence reconstruction, query‐to‐reconstructed sentence matching, and machine translation as its sub‐modules. In this work, a novel combination of rule‐based sentence simplification and triplet extraction is carried out resulting in a triplet similarity score of 86.56% for the extracted triplets. This method is superior to the existing triplet extraction method whose triplet similarity score was found to be 60.65%. Further, the proposed work makes use of heuristic rules to reconstruct sentences which when evaluated by human evaluators for meaningfulness and grammar resulted in a score of 3.09/4 and 2.95/4 respectively. To complete end‐to‐end communication in the proposed system, a similarity‐based query answer system is proposed in this work.
The cyclic response behavior, failure mechanism, and life prediction model of 9% Cr‐based steel under different strain ratios in the low cyclic fatigue regime at 430°C
Authors: Wang Quanyi , Cai Yifan , Liu Meng , Li Qingsong , Pei Yubing , Zhang Hong , Liu Yongjie , Wang Qingyuan 
Published: August 2023

AbstractDuring steam turbine rotor operation, the startup and showdown processes can cause asymmetric loading stress, leading to fatigue damage. To research the cyclic deformation behavior and fatigue failure mechanisms of 9% Cr‐based steel under asymmetric loading conditions, the strain ratios including −1, 0, and 0.1 are introduced into the low cyclic fatigue tests at 430°C. The results show the cyclic softening behavior is observed under three strain ratios at 430°C. As the strain ratio increases, the crack initiation sources, plastic strain, and consumed energy present an increasing trend. Comparing the microstructure morphology at different strain ratios, the coarsening lath and carbides affect fatigue crack initiation. Besides, the grain rotation and dynamic recrystallization can be observed, resulting in the cyclic softening behavior during the fatigue test. Finally, a new fatigue life prediction model is proposed at 430°C.
Optimization of decellularization methods using human small intestinal submucosa for scaffold generation in regenerative medicine
Authors: Mineta Shumei , Endo Shunji , Ueno Tomio 
Published: August 2023

AbstractPorcine small intestinal submucosa, despite its successful use as a scaffold in regenerative medicine, has innate biomechanical heterogeneity. In this study, we hypothesized that human small intestinal submucosa could be a viable alternative bio‐scaffold. For the first time, we characterize submucosal extraction from human small intestine and examine appropriate decellularization methods. In total, 16 human small intestinal submucosal samples were obtained and decellularized using three reported methods of porcine decellularization: Abraham, Badylak, and Luo. For each method, four specimens were decellularized. The remaining four specimens were designated as non‐decellularized. We measured the amount of residual DNA and growth factors in decellularized human intestinal samples. Additionally, decellularized human small intestinal submucosa was co‐cultured with mouse bone marrow‐derived mesenchymal stem cells to examine mesenchymal stem cell survival and proliferation. The reference value for the amount of residual DNA deemed appropriate in decellularized tissue was established as 50 ng/mg of extracellular matrix dry weight or less. Abraham's method most successfully met this criterion. Measurement of residual growth factors revealed low levels observed in samples decellularized using the Abraham and Badylak methods. Co‐culture of each small intestinal submucosal sample with mouse bone marrow‐derived mesenchymal stem cells confirmed viable cell survival and proliferation in samples derived using protocols by Abraham and Badylak. Abraham's method most successfully met the criteria for efficient tissue decellularization and cell viability and proliferation. Thus, we consider this method most suitable for decellularization of human small intestinal submucosa.
Effect of different cooking methods on selected quality criteria and polycyclic aromatic hydrocarbon content of cultivated mushrooms (Agaricus bisporus)
Authors: Erhan Seray , Proestos Charalampos , Manoharadas Salim , Oz Fatih 
Published: August 2023

SummaryThe effect of different cooking methods (boiling, sous‐vide cooking, pan‐frying, oven cooking, and barbecuing) on some quality criteria (dry matter content, pH value, cooking loss value, and antioxidant activity) and polycyclic aromatic hydrocarbon (PAH) contents of cultivated mushrooms (Agaricus bisporus) was investigated. Different cooking methods were found to have significant effects on the dry matter content, cooking loss, and pH value of the mushroom, whereas no significant effect was observed on the antioxidant activity (IC50). Benzo[a]anthracene (BaA) was detected in both raw and cooked mushroom samples, with no statistically significant difference in ∑PAH4 (BaA + Chry + BbF + BaP) content between samples. The ∑PAH4 content, initially 0.30 ng/g in raw samples, ranged from 0.34 to 3.50 ng/g across mushrooms cooked using different methods. Importantly, consumption of even 1 kg of pan‐fried mushrooms with the highest ∑PAH4 content remained within the limits defined by both the Turkish Food Codex Food Contaminants Regulation (TFC 2011) and the European Union Directive (EU 2011).
Evaluation of the acute basic biological effects of herbal formulation to control obesity: a preliminary study
Authors: Kumar Mukul , Kaushik Deepika , Kaushik Ravinder , Khan Azhar , Billeci Lucia , Oz Emel , Proestos Charalampos , Brennan Charles , Ahmad Naushad , Elobeid Tahra , Oz Fatih 
Published: August 2023

SummaryObjectivesObesity is the accumulation of excessive visceral and subcutaneous fat in the body. The herbal formulation can help treat obesity, and our study aims to evaluate the acute basic biological effects of herbal formulation to control obesity.MethodsAntiobesity herbal formulation, prepared by the combination of Saussurea lappa root, Betula utilis bark, Aconitum heterophyllum root, Bunium periscum seed, and Bauhinia variegate leaf (4:3:1:1:1), was carried out on Wistar male and female rats. Obesity was induced in the rats by feeding the Chow diet, and the effect of herbal formulation on obesity was studied. The effect on obesity was measured by analysing variables like weight, water intake, pellet count, haematological parameters, renal function test, liver function test, and lipid profile test.ResultsIn the study, it was observed that the female rats treated at the highest dose showed a significantly (P < 0.005) higher decrease in weight compared to male rats after 10 days. The food intake, haemoglobin, renal, liver function, and lipid profile showed significant improvement after the intake of herbal formulation.ConclusionsFrom the above results, it was inferred that herbal formulation increased the activity of metabolism, which is helpful in weight reduction; moreover, it has some beneficial biological effects.
Effect of the addition of an emulgel based on whey protein isolate‐alginate‐inulin complex on the physicochemical and textural properties of reduced‐fat set yoghurt
Authors: Ortiz‐Deleón Anthony M. , Román‐Guerrero Angélica , Sandoval‐Castilla Ofelia , Cuevas‐Bernardino Juan C. , Vernon‐Carter Eduardo Jaime 
Published: August 2023

SummaryOil‐in‐water emulgels formed with canola oil and whey protein isolate:alginate‐inulin ternary complex coacervates (TCC) were used as fat replacers (10–15% wt.) in a reduced‐fat set yoghurt (RFY). The addition of the emulgel had a significant effect (P < 0.05) on RFY syneresis and better stability against whey expulsion compared to a full‐fat set yoghurt (FFY). Microstructure in RFY added with emulgel showed denser packing structures in the protein lattice with filling behaviour of emulgel. The textural and rheological properties showed that the emulgel contributed to mimicking and modulating its performance like that of FFY. The complex elastic modulus (G*) indicates that higher emulgel content in RFY improved the strength of the gel, allowing it to achieve a behaviour like that of FFY. The addition of emulgel increased the protein (55.3–63.2%) and reduced the fat (30.1–42.9%) contents, allowing the development of more balanced foods with similar mechanical properties to an FFY.
Update on the global prevalence and severity of kiwifruit allergy: a scoping review
Authors: James Christopher A. , Welham Simon , Rose Peter 
Published: August 2023

SummaryThe production and use of kiwifruit, and their derived products, has seen rapid growth in the food industry with some 4 467 099 tonnes produced in 2021. A key area of development has been the increased use of kiwifruit waste streams to support sustainable food production systems. However, kiwifruit is emerging as a common elicitor of food allergy worldwide. Therefore, the present research focuses on summarising the current literature on kiwifruit‐induced human food allergy. Of the available information, a total of 7098 titles were found and 107 articles were included in the current study following full‐text screening. Most research concentrated on the prevalence of allergenicity and was performed within Europe, North America, Asia, Africa, South America and Oceania. Food allergy to kiwifruit ranged from oral allergy syndrome to anaphylaxis in humans. Few studies considered the need for labelling or public education. Given the increased usage of kiwifruit across a range of food streams, further research is required due to the greater focus on utilisation of these products in the food industry.
Ambidexterity in strategic alliances: An integrative review of the literature
Authors: Zahoor Nadia , Khan Zaheer , Marinova Svetla , Cui Lin 
Published: August 2023

AbstractStrategic alliances play a vital role in exploration and exploitation activities, otherwise known as the ambidextrous approach for value creation. This has led to an upsurge in studies on ambidexterity in strategic alliances by giving rise to various conceptualizations and theoretical challenges. However, we lack a systematic evaluation and synthesis of the theoretical and empirical insights from this growing body of research. In this paper, we use an integrative systematic literature review (SLR) approach to critically analyse 77 articles on ambidexterity in strategic alliances published in 38 leading journals across 13 disciplines. Findings from bibliometric and qualitative content analyses reveal three major research directions: (1) micro‐foundation and organizational antecedents of ambidexterity in alliances, (2) governance mechanisms of ambidexterity, and (3) relational and performance outcomes of ambidexterity. We integrate these findings into a unified framework which provides a foundation for future research on ambidexterity in strategic alliances, with implications for academics, policymakers and practitioners.
Difficulties experienced by patients with benign prostatic hyperplasia regarding their physical symptoms
Authors: Yurtseven Şeyma , Doğan Sevgi Deniz , Arslan Sevban 
Published: August 2023

AbstractBenign prostatic hyperplasia (BPH) is a significant health concern for all ageing men and is characterized by clinical symptoms resulting from the growth of benign tissues in the prostate gland. Living with a chronic disease like BPH undoubtedly affects different aspects of a person's life. This study was conducted to examine in‐depth the difficulties experienced by BPH patients who have no other option but to undergo surgery due to their symptoms. The study is qualitative research with a phenomenological design. A total of 18 patients were included in the study. Research data were obtained using the interview method, which is one of the qualitative data collection methods, and the content analysis method was used to analyse the data obtained from the interviews. Eighteen patients with ages ranging from 57 to 75 years and experiencing BPH‐related symptoms for 2–11 years participated in the study. The reactions of patients to living with BPH‐related symptoms were presented under the themes of social anxiety, social disconnection, impaired quality of sleep, and decreased sexual self‐confidence. The themes mentioned by BPH patients regarding the duration of their illness are the result of a combination of many factors. In this context, it is recommended that urology nurses provide psychological support, medical information, self‐care skills, and self‐monitoring skills to BPH patients to develop individual coping mechanisms. BPH is a significant health concern for all ageing men and is characterized by clinical symptoms resulting from the growth of benign tissues in the prostate gland. Living with a chronic disease like BPH undoubtedly affects different aspects of a person's life. It is not impossible to find solutions to patients by understanding them deeply.
How does post‐study employment policy for international students create “skilled” migrants? The case of Japan
Authors: Mazumi Yusuke 
Published: August 2023

AbstractThe recent literature on skilled migration has addressed the socially constructed nature of the notion and category of “skilled” migrants, revealing the roles of the host state and its admission policy in shaping these migrants. This article adds to the literature by examining how the host state can also socially (or politically) create “skilled” migrants through policy that facilitates the post‐study employment of international students. The extant research on the social construction of skill and skilled migration informs the hypothesizing of three strategic ways in which host states seek to retain international students who may otherwise be excluded from the host labour market after graduation: (1) the creation of new work permits, (2) the discretionary relaxing of criteria for issuing work visas and (3) the provision of skilling support for finding employment. The case of Japan empirically validates all these strategies and indicates the particular significance of the second strategy.