bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring supermassive black hole physics and galaxy quenching across halo mass in FIRE cosmological zoom simulations
Authors: Wellons Sarah , Faucher-Giguère Claude-André , Hopkins Philip F , Quataert Eliot , Anglés-Alcázar Daniel , Feldmann Robert , Hayward Christopher C , Kereš Dušan , Su Kung-Yi , Wetzel Andrew 
Published: February 2023

ABSTRACT
Feedback from accreting supermassive black holes (SMBHs) is thought to be a primary driver of quenching in massive galaxies, but how to best implement SMBH physics into galaxy formation simulations remains ambiguous. As part of the Feedback in Realistic Environments (FIRE) project, we explore the effects of different modelling choices for SMBH accretion and feedback in a suite of ∼500 cosmological zoom-in simulations across a wide range of halo mass (1010–1013 M⊙). Within the suite, we vary the numerical schemes for BH accretion and feedback, accretion efficiency, and the strength of mechanical, radiative, and cosmic ray feedback independently. We then compare the outcomes to observed galaxy scaling relations. We find several models satisfying observational constraints for which the energetics in different feedback channels are physically plausible. Interestingly, cosmic rays accelerated by SMBHs play an important role in many plausible models. However, it is non-trivial to reproduce scaling relations across halo mass, and many model variations produce qualitatively incorrect results regardless of parameter choices. The growth of stellar and BH mass are closely related: for example, overmassive BHs tend to overquench galaxies. BH mass is most strongly affected by the choice of accretion efficiency in high-mass haloes, but by feedback efficiency in low-mass haloes. The amount of star formation suppression by SMBH feedback in low-mass haloes is determined primarily by the time-integrated feedback energy. For massive galaxies, the ‘responsiveness’ of a model (how quickly and powerfully the BH responds to gas available for accretion) is an additional important factor for quenching.
Regular rotation and low turbulence in a diverse sample of z ∼ 4.5 galaxies observed with ALMA
Authors: Roman-Oliveira Fernanda , Fraternali Filippo , Rizzo Francesca 
Published: February 2023

ABSTRACT
The discovery of galaxies with regularly rotating discs at redshifts ≥4 has been a puzzling challenge to galaxy formation models that tend to predict chaotic gas kinematics in the early Universe as a consequence of gas accretion, mergers, and efficient feedback. In this work, we investigated the kinematics of five highly resolved galaxies at z ∼ 4.5 observed with ALMA in the [C ii] 158 $\mu$m emission line. The sample is diverse: AzTEC1 (starburst galaxy), BRI1335-0417 (starburst and quasar host galaxy), J081740 (normal star-forming galaxy), and SGP38326 (two starburst galaxies in a group). The five galaxies show velocity gradients, but four were found to be rotating discs, while the remaining, AzTEC1, is likely a merger. We studied the gas kinematics of the discs using 3DBAROLO and found that they rotate with maximum rotation velocities between 198 and 562 km s−1, while the gas velocity dispersions, averaged across the discs, are between 49 and 75 km s−1. The rotation curves are generally flat and the galaxies have ratios of ordered-to-random motion (V/σ) between 2.7 and 9.8. We present CANNUBI, an algorithm for fitting the disc geometry of rotating discs in 3D emission-line observations prior to modelling the kinematics, with which we find indications that these discs may have thicknesses of the order of 1 kpc. This study shows that early disc formation with a clear dominance of rotation with respect to turbulent motions is present across a variety of galaxy types.
High-stability spherical lanthanide nanoclusters for magnetic resonance imaging
Authors: Wang Hai-Ling , Liu Donglin , Jia Jian-Hua , Liu Jun-Liang , Ruan Ze-Yu , Deng Wei , Yang Shiping , Wu Si-Guo , Tong Ming-Liang 
Published: February 2023

Abstract
High-nuclear lanthanide clusters have shown great potential for the administration of high-dose mononuclear gadolinium chelates in magnetic resonance imaging (MRI). The development of high-nuclear lanthanide clusters with excellent solubility and high stability in water or solution has been challenging and is very important for expanding the performance of MRI. We used N-methylbenzimidazole-2-methanol (HL) and LnCl3·6H2O to synthesize two spherical lanthanide clusters, Ln32 (Ln = Ho, Ho32; and Ln = Gd, Gd32), which are highly stable in solution. The 24 ligands L− are all distributed on the periphery of Ln32 and tightly wrap the cluster core, ensuring that the cluster is stable. Notably, Ho32 can remain highly stable when bombarded with different ion source energies in HRESI-MS or immersed in an aqueous solution of different pH values for 24 h. The possible formation mechanism of Ho32 was proposed to be Ho(III), (L)− and H2O → Ho3(L)3/Ho3(L)4 → Ho4(L)4/Ho4(L)5 → Ho6(L)6/Ho6(L)7 → Ho16(L)19 → Ho28(L)15 → Ho32(L)24/Ho32(L)21/Ho32(L)23. To the best of our knowledge, this is the first study of the assembly mechanism of spherical high-nuclear lanthanide clusters. Spherical cluster Gd32, a form of highly aggregated Gd(III), exhibits a high longitudinal relaxation rate (1 T, r1 = 265.87 mM−1·s−1). More notably, compared with the clinically used commercial material Gd-DTPA, Gd32 has a clearer and higher-contrast T1-weighted MRI effect in mice bearing 4T1 tumors. This is the first time that high-nuclear lanthanide clusters with high water stability have been utilized for MRI. High-nuclear Gd clusters containing highly aggregated Gd(III) at the molecular level have higher imaging contrast than traditional Gd chelates; thus, using large doses of traditional gadolinium contrast agents can be avoided.
Photodegradable polar-functionalized polyethylenes
Authors: Wang Chaoqun , Xia Jian , Zhang Yuxing , Hu Xiaoqiang , Jian Zhongbao 
Published: February 2023

ABSTRACTThe degradation of plastics has attracted much attention from the global community. Polyethylenes (PEs), as the most abundant synthetic plastics, are most frequently studied. PE is non-degradable and non-polar because of the sole presence of the pure hydrocarbon components. Concurrent incorporation of both in-chain cleavable and functional groups into the PE chain is an effective pathway to overcome the non-degradable and non-polar issue; however, the method for achieving this pathway remains elusive. Here, we report a strictly non-alternating (&gt;99%) terpolymerization of ethylene with CO and fundamental polar monomers via a coordination–insertion mechanism using late transition metal catalysts, which effectively prevents the formation of undesired chelates originating from both co-monomers under a low CO concentration. High-molecular-weight linear PEs with both in-chain isolated keto (&gt;99%) and main-chain functional groups are prepared. The incorporation of key low-content isolated keto groups makes PEs photodegradable while retaining their desirable bulk material properties, and the introduction of polar functional groups considerably improves their surface properties.
Beaver activity and red squirrel presence predict bird assemblages in boreal Canada
Authors: Feldman Mariano J , Mazerolle Marc J , Imbeau Louis , Fenton Nicole J 
Published: February 2023

AbstractWetlands and predation in boreal ecosystems play essential roles throughout the breeding season for bird assemblages. We found a positive association of beaver activity and a negative influence of American red squirrels (Tamiasciurus hudsonicus) on bird assemblages. We used a multispecies hierarchical model to investigate whether bird communities differ between two major wetland habitats in boreal Canada: beaver ponds and peatland ponds. In addition to including variables such as forest cover and latitude, we adopted a structural equation model approach to estimate the occupancy of American red squirrels and its potential influence on bird communities. Using automated recording stations deployed at 50 ponds, we detected 96 bird species in 2018 and 2019. Bird species were grouped into four taxonomic guilds according to their habitat successional requirements: early successional species, late successional species, generalists, and wetland species. Beaver ponds harbored higher species richness, a pattern driven primarily by early successional species. The occupancy of almost a quarter of the species was lower in the presence of red squirrels. Late successional species responded positively to the cover of forest surrounding the pond. Our results highlight the value of considering acoustic data of red squirrels to quantify habitat quality in boreal forests. We conclude that beaver activity shapes bird assemblages through modification of their habitat, and that some bird guilds are associated negatively with the presence of American red squirrels.
Singing on the nest is a widespread behavior in incubating Northern Mockingbirds and increases probability of nest predation
Authors: Stracey Christine M , Sanchez Karina , Brown Brishauna , Hawkins Dakota , Shepherd Tricia 
Published: February 2023

Abstract
In this study, we documented for the first time singing on the nest (SOTN) in 74% of 65 Northern Mockingbird (Mimus polyglottos) nests that were monitored with continuous-running video cameras (8,353.9 hr sampled). As predicted, higher rates of SOTN significantly decreased daily survival rates of nests. SOTN occurred almost exclusively by females during the egg stage and in 86% (48 of 56) of nests for which we had sampling from the egg stage. While extensive at the population level, the average rate of SOTN per individual was low (5.24 ± 1.24 s SOTN per hour of video sampled). We found mixed support for the hypothesis that SOTN functions in territory maintenance. We found no support for the hypotheses that SOTN functions to coordinate parental care, defend nests, or aid in vocal learning. Given the limited attention SOTN has received and the mostly anecdotal accounts of it, our understanding of its costs and benefits is lacking. We conclude that while individual rates of SOTN are quite low, SOTN may be more widespread in populations than previously thought and that studies specifically designed to test hypotheses regarding potential functions are critically needed.
Deriving the dilaton potential in improved holographic QCD from the chiral condensate
Authors: Hashimoto Koji , Ohashi Keisuke , Sumimoto Takayuki 
Published: February 2023

Abstract
We derive an explicit form of the dilaton potential in improved holographic QCD (IHQCD) from the QCD lattice data of the chiral condensate as a function of the quark mass. This establishes a data-driven holographic modeling of QCD—machine-learning holographic QCD. The modeling consists of two steps for solving inverse problems. The first inverse problem is to find the emergent bulk geometry consistent with the lattice QCD simulation data at the boundary. We solve this problem with the refinement of the neural ordinary differential equation, a machine-learning technique. The second inverse problem is to derive a bulk gravity action with a dilaton potential such that its solution is the emergent bulk geometry. We solve this problem at non-zero temperature, and derive the explicit form of the dilaton potential. The dilaton potential determines the bulk action, the Einstein-dilaton system; thus we derive holographically the bulk system from the QCD chiral condensate data. The usefulness of the model is shown in the example of the prediction of the string breaking distance, whose value is found to be consistent with other lattice QCD data.
Strategies of strengthening mechanical properties in the osteoinductive calcium phosphate bioceramics
Authors: Li Qipeng , Feng Cong , Cao Quanle , Wang Wei , Ma Zihan , Wu Yonghao , He Tinghan , Jing Yangtian , Tan Wenxuan , Liao Tongxiao , Xing Jie , Li Xiangfeng , Wang Ye , Xiao Yumei , Zhu Xiangdong , Zhang Xingdong 
Published: February 2023

AbstractCalcium phosphate (CaP) bioceramics are widely applied in the bone repairing field attributing to their excellent biological properties, especially osteoinductivity. However, their applications in load-bearing or segmental bone defects are severely restricted by the poor mechanical properties. It is generally considered that it is challenging to improve mechanical and biological properties of CaP bioceramics simultaneously. Up to now, various strategies have been developed to enhance mechanical strengths of CaP ceramics, the achievements in recent researches need to be urgently summarized. In this review, the effective and current means of enhancing mechanical properties of CaP ceramics were comprehensively summarized from the perspectives of fine-grain strengthening, second phase strengthening, and sintering process optimization. What’s more, the further improvement of mechanical properties for CaP ceramics was prospectively proposed including heat treatment and biomimetic. Therefore, this review put forward the direction about how to compatibly improve mechanical properties of CaP ceramics, which can provide data and ideas for expanding the range of their clinical applications.
MCPyV-Negative Merkel Cell Carcinoma In Situ Associated With Immunosuppression
Authors: Mazumder Anika , Khoshnoodi Pooria , Gruber Jessica , Burkemper Nicole M. 
Published: February 2023

Abstract:
Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neoplasm that is almost always intradermal. Immunosuppression increases the risk of MCC, which is believed to be due to increased susceptibility to Merkel cell polyomavirus (MCPyV). Intraepidermal MCC, or MCC in situ (MCCis), is extremely rare and usually associated with other cutaneous lesions. Here, we describe a case of MCPyV-negative MCCis arising in an immunocompromised patient. This case adds to only 9 previously reported cases of MCCis without a coexisting neoplasm and suggests that immunosuppression can lead to MCCis by mechanisms other than MCPyV. Although previously reported cases of MCCis demonstrated excellent prognosis, local recurrence and metastasis are still possible. Prognostication, treatment, and follow-up of MCCis should be similar to MCC.
Langerhans Cell Histiocytosis Evolving into Juvenile Xanthogranuloma: Two Linked Entities
Authors: Shaker Nada , Sangueza Omar P. 
Published: February 2023

Background:
Langerhans cell histiocytosis (LCH) represents a myeloid clonal proliferation that involves the skin and other organs. Occasionally, cases of LCH evolve into juvenile xanthogranuloma (JXG).

Case Presentation:
A 7-month-old boy presented with an itchy, flaky rash resembling seborrheic dermatitis affecting the scalp and eyebrows. The lesions started at 2 months old. On physical examination, there were reddish/brown lesions on the trunk, denuded areas on the groin and neck, and a large lesion behind his bottom teeth. In addition, there were thick white plaques in his mouth and thick whitish material in both ears. A skin biopsy showed features of LCH. Radiologic examination demonstrated several osteolytic lesions. Chemotherapy produced marked improvement. A few months later, the patient developed lesions with clinical and histologic features of XG.

Conclusion:
A possible association between LCH and XG is explained by lineage maturation development. Chemotherapy may play a role in modifying the production of cytokines that enhance the transformation or ‘maturation’ of Langerhans cells into multinucleated macrophages (Touton cells) characteristic of a more favorable proliferative inflammatory condition.
Variability of expert assessments of ECG time domain parameters
Authors: Böck Carl , Mörtl Christoph , Mahringer Christoph , Huemer Mario , Meier Jens 
Published: February 2023

BACKGROUND
In anaesthesiology, time domain parameters of the ECG are frequently used for long QT diagnosis, determination of branch blocks and for identifying atrioventricular blocks. However, this analysis depends on several factors and therefore the time domain parameters are prone to variability.

OBJECTIVE
To determine the variability of expert assessments of ECG time domain parameters in daily clinical practice.

DESIGN
In an observational study 18 physicians labelled the onset, peak and end of the waves (P-QRS-T) for 26 preselected, distinctive beats. Based on this, clinically important durations and intervals were derived: the duration of the P wave, T wave and QRS complex, as well as the length of the PQ and QT interval. These parameters were subsequently analysed with respect to inter-expert variability (for all experts and discipline-based subgroups) and, additionally, were compared with computer-aided analysis.

SETTING
ECG recordings from participating patients were recorded in March 2015 during standard examination in the hospital and stored in the local ECG database.

PATIENTS
We did not define inclusion or exclusion criteria for the patients themselves; the ECG beats were selected by a medical expert with respect to their shapes and abnormalities.

MAIN OUTCOME MEASURES
Variability of clinically relevant ECG wave durations and intervals quantified were expressed as the interquartile range and the Q2/Q98 span for 18 investigators.

RESULTS
The resulting wave durations (Pdur, QRSdur and Tdur) and intervals (PQ and QT) showed high variability, for instance, captured by the Q2/Q98 span ranging from 39 to 99 ms.

CONCLUSION
The observed, inter-investigator variability of assessing the PQ and QT intervals, as well as the wave durations, might result in important variance regarding ECG-associated diagnoses. Whether these variances play a major role in typical clinical situations would have to be demonstrated with further clinical observational studies.
Accuracy and Precision of Point-of-Care International Normalized Ratio in Patients With Liver Disease
Authors: Shadlyn Tevyn , Bauman Mary , Tandon Puneeta , Yap Jason , Kawada Patricia 
Published: February 2023

Objective:
To determine if the CoaguChek XS Pro Point-of-Care (POC) device can accurately and precisely measure the international normalized ratio (INR) compared with the gold standard laboratory INR in pediatric and adult patients with liver disease.

Methods:
This prospective cohort study included 15 pediatric patients without liver disease, 13 pediatric patients with liver disease, and 17 adult patients with liver disease. The accuracy of the POC INR values was determined using the correlation and Bland-Altman limits of agreement. The accuracy of the coagulometer INR was assessed by calculating the proportion of POC INR measurements that were ≤15% of their corresponding laboratory INR.

Results:
A comparison of INR measurements showed an excellent correlation in pediatric patients without liver disease (r = 0.82), pediatric patients with liver disease (r = 0.89), and adult patients with liver disease (r = 0.96). Fourteen (93%) POC INR values were ≤15% in pediatric patients without liver disease from its paired laboratory INR. All 13 paired measurements were ≤15% in pediatric patients with liver disease. In adult patients with liver disease, 12 (71%) POC INR values were ≤15% of their paired laboratory INR.

Conclusions:
In patients with liver disease, the CoaguChek XS Pro provides an accurate measure of the INR compared to laboratory INR measurements.
Feasibility of Left Ventricle Ejection Fraction Calculation Using Electrocardiographically Gated SPECT Acquisition of 99mTc-HDP Bone Scintigraphy in Cardiac Amyloidosis
Authors: te Beek Erik T. , Lafeber Albert , Postema Jan W.A. , Constandse Jan , Ronner Eelko , ten Broek Marc R.J. 
Published: February 2023

Abstract
We performed bone scintigraphy in 6 patients with suspected cardiac amyloidosis. To evaluate feasibility of left ventricle function analysis, we additionally performed electrocardiographically gated SPECT acquisition. The cardiac-gated SPECT data confirmed adequate tracer uptake for automatic myocardial contour determination. LVEF estimations ranged between 24% and 54%. Comparison with LVEF estimations from prior echocardiography generally showed only small differences. In one patient, the LVEF measurements from both methods seemed discordant, probably reflecting actual LVEF worsening, which was confirmed at follow-up echocardiography. Therefore, our results may suggest that cardiac-gated SPECT acquisition at bone scintigraphy can provide meaningful estimates of LVEF.
Solitary Malignant Peripheral Nerve Sheath Tumor of Lumbar Vertebra Mimicking Metastatic Malignancy
Authors: Guo Ziyu , Liu Wei , Dong Ziqian , Yang Lan , Xie Peng 
Published: February 2023

Abstract
Malignant peripheral nerve sheath tumor involving solitary lumbar vertebra is extremely rare. A 72-year-old man had a chief complaint of growing lumbocrural pain for 2 months. The CT scan detected a solitary vertebral lesion, which highly supported the diagnosis of metastatic malignancy. 18F-FDG PET/CT demonstrated that the vertebral lesion had heterogeneous intense FDG accumulation with an SUVmax of 16.4. The pathological examination confirmed the diagnosis of malignant peripheral nerve sheath tumor. This case highlights that MPNST should be considered when there is solitary vertebra invasion with increased FDG uptake.
Identification of cell type-specific gene targets underlying thousands of rare diseases and subtraits
Authors: Murphy Kitty B. , Gordon-Smith Robert , Chapman Jai , Otani Momoko , Schilder Brian M. , Skene Nathan G. 
Published: February 2023

AbstractRare diseases (RDs) are uncommon as individual diagnoses, but as a group contribute to an enormous disease burden globally. However, partly due the low prevalence and high diversity of individual RDs, this category of diseases is understudied and under-resourced. The advent of large, standardised genetics databases has enabled high-throughput, comprehensive approaches that uncover new insights into the multi-scale aetiology of thousands of diseases. Here, using the Human Phenotype Ontology (9,677 annotated phenotypes) and multiple single-cell transcriptomic atlases (77 human cell types and 38 mouse cell types), we conducted >688,000 enrichment tests (x100,000 bootstrap iterations each) to identify >13,888 genetically supported cell type-phenotype associations. Our results recapitulate well-known cell type-phenotype relationships, and extend our understanding of these diseases by pinpointing the genes linking phenotypes to specific cell (sub)types. We also reveal novel cell type-phenotype relationships across disparate branches of clinical disease (e.g. the nervous, cardiovascular, and immune systems). Next, we introduce a computational pipeline to prioritise gene targets with high cell type-specificity to minimise off-target effects and maximise therapeutic potential. To broaden the impact of our study, we have released two R packages to fully replicate our analyses, as well as a series of interactive web apps so that stakeholders from a variety of backgrounds may further explore and utilise our findings. Together, we present a promising avenue for systematically and robustly uncovering the multi-scale aetiology of RDs at scale.