bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced identification of membrane transport proteins: a hybrid approach combining ProtBERT-BFD and convolutional neural networks
Authors: Ghazikhani Hamed , Butler Gregory 
Published: July 2023

Abstract
Transmembrane transport proteins (transporters) play a crucial role in the fundamental cellular processes of all organisms by facilitating the transport of hydrophilic substrates across hydrophobic membranes. Despite the availability of numerous membrane protein sequences, their structures and functions remain largely elusive. Recently, natural language processing (NLP) techniques have shown promise in the analysis of protein sequences. Bidirectional Encoder Representations from Transformers (BERT) is an NLP technique adapted for proteins to learn contextual embeddings of individual amino acids within a protein sequence. Our previous strategy, TooT-BERT-T, differentiated transporters from non-transporters by employing a logistic regression classifier with fine-tuned representations from ProtBERT-BFD. In this study, we expand upon this approach by utilizing representations from ProtBERT, ProtBERT-BFD, and MembraneBERT in combination with classical classifiers. Additionally, we introduce TooT-BERT-CNN-T, a novel method that fine-tunes ProtBERT-BFD and discriminates transporters using a Convolutional Neural Network (CNN). Our experimental results reveal that CNN surpasses traditional classifiers in discriminating transporters from non-transporters, achieving an MCC of 0.89 and an accuracy of 95.1 % on the independent test set. This represents an improvement of 0.03 and 1.11 percentage points compared to TooT-BERT-T, respectively.
Language and the mind: how language shapes our thinking
Authors: Zhou Xiaodi 
Published: July 2023

Abstract
This paper analyzes languages and their connections to thinking and culture using an autoethnographic lens. This autoethnography utilized personal examples and those from the author’s students’ compositions as evidence of the link between languages and cultures. Both named languages and dialects of those languages are contemplated for the basis of how their traits influence perceptions. A neuroscientific rationale is also made between human languages and human cultures. The link between culture and language, including dialects, is made, positioning the act of translanguaging as real time dialogue between cultures. Finally, classroom implications are presented with actual student writing and multimodal performances to showcase how students’ cultures are manifested via classroom engagements, particularly through translanguaging.
Catalytic oxidation degradation of volatile organic compounds (VOCs) – a review
Authors: Liu Wenju , Zhang Zheng , Yuan Kailong , Dang Dan , Jin Peng , Han Xiaofei , Ge Qun 
Published: July 2023

Abstract
Volatile organic compounds (VOCs) are considered one of the significant contributors to air pollution because they are toxic, difficult to remove, come from a wide range of sources, and can easily cause damage to the environment and human health. There is an urgent need for effective means to reduce their emissions. The current treatment technologies for VOCs include catalytic oxidation, adsorption, condensation, and recovery. Catalytic oxidation technology stands out among the others thanks to its high catalytic efficiency, low energy requirement, and lack of secondary pollution. The difficulty of this technology lies in the development of efficient catalysts. The research on loaded noble metal catalysts and non-noble metal oxide catalysts in this area over the past few years is briefly described in this work. Firstly, the catalytic destruction mechanism of organic volatile compounds is introduced. Secondly, the effects of structural modulation during catalytic oxidation, such as the adjustment of noble metal particle size and morphology, metal doping, and defect engineering, on the conformational relationships are discussed. Finally, the challenges faced by thermal catalytic oxidation for the degradation of VOCs are discussed, and the prospects for its development are presented.
Un análisis histórico de la evolución y continuidad de la relación entre China y América Latina
Authors: Jiang Meijie 
Published: July 2023

Resumen
Desde hace más de una década, China ha sido un actor clave en la relación comercial y política con América Latina. ¿Qué ha motivado la presencia China en América Latina? ¿Y cuáles son los cambios y las continuidades a lo largo del tiempo? Este trabajo ha abordado estas cuestiones desde una perspectiva histórica. Adoptando una metodología deductiva, el análisis señala que los Cinco Principios de Coexistencia Pacífica y la política de Una Sola China han mantenido su coherencia y relevancia en la relación exterior china con América Latina. Al mismo tiempo, se ha identificado cuatro cambios notables: 1) se ha pasado de la indiferencia ideológica inicial a un compromiso económico cada vez más fuerte; 2) se ha producido una transición del auge de las materias primas a un portafolio más diversificado con un mayor énfasis en la tecnología y la innovación; 3) China ha pasado de ser un N
orm-Taker a un N
orm-Maker en el escenario internacional; 4) se ha pasado de un enfoque predominantemente bilateral a uno más multilateral.
Change in gastric-lipase adsorption on lipid layer by stigmasterols
Authors: Shin Gounhanul , Hadinoto Kunn , Park Jin-Won 
Published: July 2023

Abstract
Gastric-lipase (GL) binding to a lipid layer was investigated for the phase of the layer adjusted with the ratio of stigmasterol to the lipid using surface plasmon resonance. While the layer was formed on the hydrophobic surface, more stigmasterol led to lower surface density only in the dipalmitoylphosphatidylcholine (DPPC) layer. The addition of stigmasterol was believed to transform the phase (condensed liquid-phase) of DPPC layer closer to the phase (expanded liquid-phase) of dioleoylphosphatidylcholine (DOPC) layer. At a ratio greater than 15:85, the effect of the stigmasterol on the DPPC was saturated. The adsorption behavior of GL showed the similar trend with the lipid formation. The adsorption increased with the increase in the ratio of stigmasterol to lipid up to 15:85. On the DOPC layer of the expanded liquid-phase, the most adsorption seemed to occur and was indistinguishable from that in the DPPC layer of 15:85. The surface density of the adsorbed GL was interpreted into the fraction of the stigmasterol-dependent DPPC, 0.33, 0.67, and 1.00 for 10:90, 5:95, and 0:100 of DPPC. Furthermore, the equilibrium constant was between 1 × 1013 M−1 and 2 × 1013 M−1 and the kinetics of the adsorption showed an increase in the adsorption rate constant with the increase of the ratio up to 15:85.
The Effect of Innovation, Economic Freedom, Macroeconomic Variables on GDP
Authors: Elina Sefria , Setyadharma Andryan 
Published: July 2023

The G-20 is a group of 19 countries with the largest economies in the world plus the European Union. Basically, the role of the G-20 in the economy is to maintain stable and high economic growth, realizing balanced growth between developed and developing countries. but based on data, the average GDP growth of the G-20 group in 2014 to 2019 was always below the world average even though the G-20 member countries had a systemic impact on the global economy. This study aims to analyze the effect of innovation, economic freedom, and macroeconomic variables on economic growth in the G-20. The data used in this research is secondary data. This study uses a fixed-effect model with panel data regression, consisting of 19 G-20 member countries for the 2009-2019 period. The results of this study indicate that innovation and economic freedom have no significant effect on economic growth in the 19 G-20 member countries. Inflation and population have a negative and significant effect on economic growth in the 19 member countries of the G-20. Meanwhile, FDI and trade have a positive and significant impact on economic growth in the 19 G-20 member countries.
G-20 adalah 19 negara dengan ekonomi besar di dunia ditambah dengan organisasi Uni Eropa yang berperan untuk menjaga pertumbuhan ekonomi yang stabil dan tinggi antara negara maju dan negara berkembang. Berdasarkan data, rata-rata pertumbuhan PDB kelompok G-20 pada tahun 2014 hingga 2019 selalu berada di bawah rata-rata dunia meskipun negara-negara anggota G-20 berdampak sistemik terhadap perekonomian global. Penelitian ini bertujuan untuk menganalisis pengaruh inovasi, kebebasan ekonomi, dan variabel makroekonomi terhadap pertumbuhan ekonomi di G-20. Data yang digunakan adalah data sekunder. Penelitian ini menggunakan model fixed effect dengan regresi data panel, terdiri dari 19 negara anggota G-20 periode 2009-2019. Hasil penelitian ini menunjukkan bahwa inovasi dan kebebasan ekonomi tidak berpengaruh signifikan terhadap pertumbuhan ekonomi di 19 negara anggota G-20. Inflasi dan jumlah penduduk berpengaruh negatif dan signifikan terhadap pertumbuhan ekonomi di 19 negara anggota G-20. Sedangkan FDI dan perdagangan berpengaruh positif dan signifikan terhadap pertumbuhan ekonomi di 19 negara anggota G-20.
Asthma Quality Measurement and Adverse Outcomes in Medicaid-Enrolled Children
Authors: Jefferson Akilah A. , Brown Clare C. , Eyimina Arina , Goudie Anthony , Rezaeiahari Mandana , Perry Tamara T. , Tilford J. Mick 
Published: July 2023

OBJECTIVES
To determine the association between the asthma medication ratio (AMR) quality measure and adverse outcomes among Medicaid-enrolled children with asthma in Arkansas, given concerns regarding the utility of the AMR in evaluating pediatric risk of asthma-related adverse events (AAEs).

METHODS
We used the Arkansas All-Payer Claims Database to identify Medicaid-enrolled children with asthma using a nonrestrictive case definition and additionally using the standard Healthcare Effectiveness Data and Information Set (HEDIS) persistent asthma definition. We assessed the AMR using the traditional dichotomous HEDIS AMR categorization and across 4 expanded AMR categories. Regression models assessed associations between AMR and AAE including hospitalization and emergency department utilization, with models conducted overall and by race and ethnicity.

RESULTS
Of the 22 788 children in the analysis, 9.0% had an AAE (6.7% asthma-related emergency department visits; 3.0% asthma-related hospitalizations). We found poor correlation between AMR and AAE, with higher rates of AAE (10.5%) among children with AMR ≥0.5 compared with AMR &lt;0.5 (8.5%; P &lt; .001), and similar patterns stratified by racial and ethnic subgroups. Expanded AMR categorization revealed notable differences in associations between AMR and AAEs, compared with traditional dichotomous categorization, with worse performance in Black children.

CONCLUSIONS
The AMR performed poorly in identifying risk of adverse outcomes among Medicaid-enrolled children with asthma. These findings underscore concerns of the utility of the AMR in population health management and reliance on restrictive HEDIS definitions. New population health frameworks incorporating broader considerations that accurately identify at-risk children are needed to improve equity in asthma management and outcomes.
<em>Siraitia grosvenorii</em> Extract Attenuates Airway Inflammation in a Mouse Model of Respiratory Disease Induced by Particulate Matter 10 Plus Diesel Exhaust Particles
Authors: Sung Yoon-Young , Kim Mi-Sun , Yuk Heung Joo , Kim Seung-Hyung , Yang Won-Kyung , Park Geum Duck , Kim Kyung Seok , Ham Woo Jung , Kim Dong-Seon 
Published: July 2023

Exposure to particulate matter (PM) causes considerable breathing-related health risks. We assessed the inhibitory effect of Siraitia grosvenorii extract (SGE) on airway inflammation in mice exposed to a fine dust mixture of PM10 (PM diameter &amp;lt; 10 mm) and diesel exhaust particles (DEPs) known as PM10D. SGE attenuated neutrophil infiltration and the number of immune B and T cells in lung tissue and bronchoalveolar lavage fluid (BALF) of PM10D-exposed mice. SGE reduced the secretion of cytokines and chemokines, including interleukin (IL)-1a, tumor necrosis factor (TNF)- a, IL-17, chemokine (C-X-C motif) ligand (CXCL)-1, and macrophage inflammatory protein (MIP)-2 in BALF. Airway inflammation, accumulation of inflammatory cells, and collagen fibrosis in the lung after PM10D exposure were investigated by histopathological analysis, and SGE treatment ameliorated these symptoms. SGE decreased the mRNA expression of mucin 5AC (MUC5AC), CXCL-1, TNF-a, MIP-2, and transient receptor potential vanilloid and ankyrin 1 ion channels in the lung tissues of mice. Furthermore, SGE ameliorated mitogen-activated protein kinase (MAPK)/nuclear factor-kappa B (NF-κB) signaling activated by PM10D in mice. We conclude that SGE attenuated PM10D-induced neutrophilic airway inflammation via inhibiting MAPK/NF-κB activation. These results show that SGE may be a candidate for the treatment of inflammatory respiratory diseases.
The Conversion of Sorghum (Sorghum bicolor (L.) Moench) Stem Waste into Activated Carbon by the Pyrolysis Method Using ZnCl2 Activator
Authors: Andini Natasya Dian , Prasetiyani Yuliana , Mumtahinah Fisafillah Al , Yudha Cornelius Satria , Astika Bintari 
Published: July 2023

<p><strong>Abstract.</strong> The use of activated carbon in Indonesia is expanding along with the increasing demand for activated carbon. Therefore, it is necessary to continue to search for raw materials and methods for producing activated carbon to produce high-quality activated carbon. Sorghum stalk (Sorghum bicolor (L.) Moench) is used as a new precursor for the formation of activated carbon by utilizing a ZnCl<sub>2</sub> activator followed by pyrolysis in a furnace with a temperature of 800°C. This study aims to determine the effect of drying and the concentration of activator agents on activated carbon production. The ZnCl<sub>2</sub> activator concentrations used were 15% and 30%. The results showed that the activated carbon obtained through the withdrawal process with a ZnCl<sub>2</sub> concentration of 30% had the highest carbon content, namely 100%. Test results with FTIR spectroscopy showed that the activated carbon samples had groups (C-H), (O-H), (C≡C), (C=O), (C=C), and (C-O). In addition, the SEM test results showed that the surface of the activated carbon formed had many pores. With the presence of activated carbon from sorghum stem waste, it is hoped that this product can reduce the contaminants contained in wastewater.</p><p><strong>Keywords: </strong></p><p><strong></strong>Activation, Activated Carbon, Waste, Pyrolysis, Sorghum, ZnCl<sub>2</sub></p>
Return to Sports and Return to Work After Total Knee Arthroplasty
Authors: Pasqualini Ignacio , Emara Ahmed K. , Rullan Pedro J. , Pan Xuankang , Simmons Hannah L. , Molloy Robert M. , Krebs Viktor E. , Piuzzi Nicolas S. 
Published: July 2023

Background:
Return to work (RTW) and sports (RTS) are critical gauges to improvement among patients after total knee arthroplasty (TKA). This study aimed to determine rates, timelines, and prognostic factors associated with RTW and RTS outcomes after primary TKA.

Methods:
A systematic review was conducted on MEDLINE, Embase, and CENTRAL databases, with 44 studies meeting inclusion/exclusion criteria. The risk of bias was assessed using the Risk of Bias in Nonrandomized Studies of Interventions tool. Meta-analysis and pooled analysis were conducted when possible with forest plots to summarize odds ratios and associated 95% confidence intervals (CIs).

Results:
The pooled RTW rate across all studies was 65% (95% CI, 51%-77%), with rates varying significantly from 10% to 98%. The mean time to RTW was of 12.9 weeks (range, 5-42). A time point analysis showed increasing RTW rates with a maximum rate at 1 year of 90%. Increased age was associated with lower RTW rates (p < 0.001). The RTS rate ranged from 36% to 100%, with a pooled rate of 82% (95% CI, 72%-89%). The mean time to RTS was 20.1 weeks (range, 16-24). A wide range of reported recurrence rates was observed among different sports (subgroup differences, p ≤ 0.001). The RTS ranged from 43% to 98%, with a pooled proportion of 76% (95% CI, 59%-87%, I2 = 91%) for low-intensity sports, and from 0% to 55% for high-intensity sports, with a pooled proportion of 35% (95% CI, 20-52, I2 = 70%).

Conclusion:
Most patients successfully return to sports and work after TKA, with rates of RTW increasing to 90% after 1 year. Such outcomes are heavily influenced by nonmodifiable (e.g., age) and modifiable (e.g., intensity of sports/employment) factors. Generally, young adults and patients with low-demand jobs can be reinitiated earlier, albeit with increasing restrictions with rising intensity. Providers should screen patients for desire to RTW and/or RTS after surgery and provide appropriate recommendations as part of necessary preoperative education and postoperative care.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Climate change and fisheries affect benthic composition and diversity in the North Sea - Investigations at the Dogger Bank during three decades (1991-2021)
Authors: Hahn Sarah Joy , Brandt Angelika , Sonnewald Moritz 
Published: July 2023

Abstract

Over a period of 30 years (1991–2021) benthic fauna was monitored at a long-term sampling station at the NATURA2000 marine protected area Dogger Bank and at a reference station in Dutch waters, using a ring dredge and a 2 m beam trawl. Changes of benthic diversity of 127 species were detected in 238 temporally distributed samples and correlated with temperature and intensity of bottom fishing. Our results provide a solid benchmark for future research in the German Exclusive Economic Zone. During the timeframe of our study, the temperature at depths below 30 m remarkably increased by 4°C, while fishing pressure in the studied ICES rectangles decreased over the past 30 years from over 100.000 h of trawling per year to about 20.000 h. The numbers of benthic individuals sampled each year show a negative trend, while the number from 1991 to 2001 is first more influenced by fishing, later by temperature. An analysis of the benthic fauna at some stations adjacent to the long-term sampled station, sampled in 2021, showed that species composition is comparatively uniform over space and that therefore long-term sampling of one station can be used as a proxy for its surroundings in this area.
Removal of Enrofloxacin using Eichhornia crassipes in microcosm wetlands
Authors: Teglia Carla M. , Hadad Hernán R. , Uberti-Manassero Nora , Siano Álvaro S. , Repetti María R. , Goicoechea Héctor C. , Culzoni María J. , Maine María A. 
Published: July 2023

Abstract
The global consumption of antibiotics leads to their possible occurrence in the environment. In this context, nature-based solutions (NBS) can be used to sustainably manage and restore natural and modified ecosystems. In this work, we studied the efficiency of the NBS free-water surface wetlands (FWSWs) using Eichhornia crassipes in microcosm for enrofloxacin removal. We also explored the behavior of enrofloxacin in the system, its accumulation and distribution in plant tissues, the detoxification mechanisms, and the possible effects on plant growth. Enrofloxacin was initially taken up by E. crassipes (first 100 hours) and then it accumulated in the sediment. Removal rates above 94% were obtained in systems with sediment and sediment + E. crassipes. In addition, enrofloxacin was found in leaves, petioles and roots (8.8–23.6 µg, 11-78.3 µg and 10.2–70.7 µg, respectively). Furthermore, enrofloxacin and degradation products were quantified in tissues and chlorosis was observed on days 5 and 9. Finally, the degradation products of enrofloxacin were analyzed, and four possible metabolic pathways of enrofloxacin in E. crassipes were described.
The spatial three-dimensional positional relationship between the posterior cruciate ligament tibial insertion and the posterior septum: an anatomical study
Authors: Chen Zhen , Shang Ziqi , Li Zhikuan , Jin Lingpeng , Tian Siman , Geng Yue , Niu Yingzhen , Dong Jiangtao 
Published: July 2023

Abstract
Background
The posterior cruciate ligament (PCL) tibial insertion and posterior septum are important factors affecting the success rate of posterior cruciate ligament reconstruction(PCLR). The purpose of this study was to accurately quantify the anatomical features and relationship of the PCL tibial insertion and posterior septum.
Methods
Twelve cadaveric human knees were dissected to investigate the PCL and posterior septum. First, the anatomical localization of the PCL, tibial insertion and posterior septum were observed from the medial and lateral sides of the knee joint using a U-shaped capsulotomy. Second, the border length and insertion of the PCL tibial insertion were measured with a soft ruler, and a tibial tunnel was created within the anatomical footprint of the PCL while preserving the integrity of the posterior septum, and the ratio of tunnel exit to PCL tibial insertion was calculated. Finally, HE staining was performed to evaluation the blood vessels content in the posterior septum.
Results
The PCL and its tibial insertion were located medial to the posterior septum in all specimens, and the inferior border of the inserion is adjacent to the posterior capsule reflexion and above the shipboard-like structure. The PCL tibial insertion had a right-angle trapezoidal-like structure with narrow superior and wide inferior sides. The superior and inferior sides of the insertion were approximately (8.8 ± 1.7) and (13.4 ± 3.2) mm, respectively, and the medial and lateral sides were approximately (11.5 ± 1.2) and (12.1 ± 0.3) mm, with an area of approximately (123.3 ± 31.4) mm². Compared to the posterior capsule, the posterior septum contained abundant blood vessels.
Conclusion
The PCL in the posterior compartment of the knee follows the posterior septum and is located entirely medial to the posterior septum, and the inferior border of the PCL tibial inserion is adjacent to the posterior capsule reflexion and above the shipboard-like structure. It is feasible to create an effective tibial tunnel within the tibial footprint of the PCL while preserving the posterior septum.