bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical experience with next-generation sequencing–based liquid biopsy testing for cancer detection in dogs: a review of 1,500 consecutive clinical cases
Authors: O’Kell Allison L. , Lytle Katherine M. , Cohen Todd A. , Wong Lilian K. , Sandford Emily , Rafalko Jill M. , Brandstetter Gina , DiMarzio Lauren R. , Phelps-Dunn Ashley , Rosentel Michelle C. , Warren Chelsea D. , McCleary-Wheeler Angela L. , Fiaux Patrick C. , Marass Francesco , Marshall Maggie A. , Ruiz-Perez Carlos A. , Kruglyak Kristina M. , Tynan John A. , Hicks Susan C. , Grosu Daniel S. , Chibuk Jason , Chorny Ilya , Tsui Dana W. Y. , Flory Andi 
Published: March 2023

Abstract

OBJECTIVE
To review ordering patterns, positivity rates, and outcome data for a subset of consecutive samples submitted for a commercially available, blood-based multicancer early-detection liquid biopsy test for dogs using next-generation sequencing at 1 laboratory.

SAMPLE
1,500 consecutively submitted blood samples from client-owned dogs with and without clinical suspicion and/or history of cancer for prospective liquid biopsy testing between December 28, 2021, and June 28, 2022.

PROCEDURES
We performed a retrospective observational study, reviewing data from 1,500 consecutive clinical samples submitted for liquid biopsy testing. Outcome data were obtained via medical record review, direct communication with the referring clinic, and/or a patient outcome survey through October 16, 2022.

RESULTS
Sixty-four percent (910/1,419) of reportable samples were submitted for cancer screening, 26% (366/1,419) for aid in diagnosis, and 10% (143/1,419) for other indications. The positivity rate was 25.4% (93/366) in aid-in-diagnosis patients and 4.5% (41/910) in screening patients. Outcome data were available for 33% (465/1,401) of patients, and outcomes were classifiable for 428 patients. The relative observed sensitivity was 61.5% (67/109) and specificity was 97.5% (311/319). The positive predictive value was 75.0% (21/28) for screening patients and 97.7% (43/44) for aid-in-diagnosis patients, and the time to diagnostic resolution following a positive result was < 2 weeks in most cases.

CLINICAL RELEVANCE
Liquid biopsy using next-generation sequencing represents a novel tool for noninvasive detection of cancer in dogs. Real-world clinical performance meets or exceeds expectations established in the test’s clinical validation study.
Citrullinemia is a suitable biomarker for post weaning performance in piglets under intensive farming
Authors: Soraci Alejandro L. , Decundo Julieta M. , Dieguez Susana N. , Martínez Guadalupe , Pérez Gaudio Denisa S. , Amanto Fabián A. 
Published: March 2023

Abstract

OBJECTIVE
To describe citrullinemia profiles during the weaning transition and correlate citrulline production with stress and growth in a commercial pig farm.

ANIMALS
240 healthy piglets of homogenous weight, weaned from second and third parity sows, were selected at weaning and subjected to the farm’s routine management practices in May to July 2020 and May to July 2021.

PROCEDURES
Piglets were weighed at weaning, then 15 and 49 days later in order to calculate daily weight gain during the first 15 and 49 days after weaning. Blood samples were collected from each piglet to determine citrulline and cortisol profiles during the early postweaning period.

RESULTS
Citrullinemia decreased dramatically during the first week postweaning and then increased progressively to reach preweaning values by 15 days postweaning. Citrulline production during the first 2 weeks postweaning was negatively correlated with cortisol production (r: –0.2949) and positively correlated with mean daily weight gain during the first 15 (ρ: 0.5450) and 49 (ρ: 0.6603) days postweaning.

CLINICAL RELEVANCE
Citrullinemia profile of piglets during the early postweaning period showed a temporal negative impact of stress (assessed by plasmatic cortisol levels) on intestinal enterocytes’ mass and function, which resulted in a lower average daily weight gain. We demonstrated that a single biomarker, plasmatic citrulline, is useful to describe intestinal metabolism during the early postweaning period and that the greater the citrulline production during the first days after weaning, the higher the weight gain during the entire postweaning period.
Highly Similar Average Collateral Effect of Synonymous Mutations Across Alternative Reading Frames: A Potential Role In Evolvability
Authors: Wichmann Stefan , Ardern Zachary 
Published: March 2023

Abstract
Synonymous mutations in a protein coding gene lead to a remarkably similar average “collateral” mutation effect size across alternative reading frames (1). Here we quantify the rarity of this feature among possible block structure codes as 0.77%. Then we develop a simple model of evolutionary search with two types of mutation. Across different mutation step sizes and ratios of the two types, the fitness-maximizing region corresponds to using a single average mutation value. The analogous constant average collateral mutation effect observed for the standard genetic code may likewise facilitate evolutionary search in alternative frame sequences.
BANCA DE INVERSIÓN: INVERSIÓN EN NUEVAS TENDENCIAS
Authors: López Medina Belén , Fernández Mora Sara , Llorente Gradus Deborah , Peco Salas Mercedes 
Published: March 2023

El presente artículo tiene como objetivo investigar y estudiar las nuevas tendencias de inversión en Banca Privada, los motivos por los que se está aumentando su presencia en los mercados y en la creación de diferentes carteras modelo en base al perfil de riesgo de cada cliente. Para entender mejor las necesidades y demanda de cada cliente se ha realizado una encuesta a 84 banqueros españoles a través de LinkedIn.
En primer lugar, a partir de las conclusiones obtenidas a través de la encuesta, se estudia el entorno económico y cada una de las nuevas tendencias de inversión propuestas: Revolución 4.0: robótica e inteligencia artificial, nuevas tendencias sostenibles, nuevas tendencias de bienestar y consumo, digitalización y conectividad de la sociedad, biotecnología y tecnologías médicas y nuevas tendencias de educación.
Por último, a partir de los cinco perfiles de riesgo aceptados en el mercado (defensivo, conservador, moderado, decidido y renta variable), se ha creado una cartera de inversión temática ajustada a las necesidades de rentabilidad y riesgo de cada uno de estos.
This study stems from an artistic phenomenon that has its traces in a poetic function which observes the milestone of creation in employing in employing the Qur’anic intertextuality in the poetry of Ashja 'al-Salami. Intertextuality is a met
Authors: Rashid Mayada 
Published: March 2023

ABSTRACT

This study stems from an artistic phenomenon that has its traces in a poetic function which observes the milestone of creation in employing in employing the Qur’anic intertextuality in the poetry of Ashja 'al-Salami. Intertextuality is a method of modern studies suitable for poets' poetry in employing the technicality of origins and belongings to supplement their texts with anew power , especially the use of the Qur’an, literature in an artistic way that increases the indications and richness of the poetic text, and opens wide horizons for contemplation and interpretation)) especially, when this artistic creativity is from a creative poet with his religious outcome. Intertextuality is based on previous texts absent in the poet’s memory, and nothing is more beautiful and deeper than employing the heritage of religious culture and Qur’anic texts that have a prominent effect on deepening the meaning and enriching the text artistically and intellectually. The research relied on the descriptive and analytical approach in tracking, monitoring, describing and analyzing the phenomenon of intertextuality.
The poet Ashjae Alsalmi, like the other poets, he drew a lot from the meanings of the Noble Qur’an and its vocabulary, for he does not cease to refer to the Qur’anic text and the religious heritage which are entrenched in himself, to obtain what nourishes and benefits his poetry, and to highlight the effectiveness of intertextuality in showing the dimensions of poetic experience.
The concept of intertextuality is a broad and comprehensive concept, as it accommodates various forms of textual interaction, therefore it is not subject to retraction and reduction in any form All poets used it in their poems and excelled in their handling of it, whether in direct or indirect intertextuality with the words of the Noble Qur’an and its meanings, and among them the poet of Ashjae Alsalmi who is the topic of this research.
The Media of the Descent of Jesus, peace be upon him, by Imam Abd al-Rahman bin Abi Bakr Jalal al-Din al-Suyuti, who died (year 911 AH) - study and investigation -
Authors: Lifatah Lafatah 
Published: March 2023

The author has scribed the descent of Jesus (peace be upon him) in the last days of the world, and that he will govern according the laws of our Prophet Muhammad (peace be upon him), and he preached his nation about the coming of the Prophet Muhammad (peace be upon him), and he will look to the Quran and will understand all provisions relating to Islamic law without the need to review the Sunnah, He will rule in the money funds unlike what exists now, which means that he will rul as it is ruled by the Prophet (peace be upon him). Jesus will come after Al- Mahdi, Al-Mamahdi and fills the earth with justice as it is filled injustice then Jesus will come and support the creation of Al-Mahdi. Then the author mention the meeing between Jesus and the Prophet Muhammad (peace and blessing upon them) and support this subject with many evidences, including the dignity of the ascetic to see the Prophet vigilant. he will reveal to him by Gabriel (peace be upon him), and then the descent of Gabriel to the earth after the death of the Prophet (peace be upon him) which, contrdicts to what some people are saying that Gabriel is not coming off after the death of the Prophet (peace be upon him). The author ended his book that Jesus will pray behind Al-Mahdi .
The saying of Bukhari (He disagrees with his hadith) A critical study in his book The Middle History
Authors: Mohammed Ibrahim , Mohammed Aboothar 
Published: March 2023

Al-Bukhari gives several words to the narrators in his book Al-Tarikh Al-Awsat, including the word: (he contradicts in his hadith), that is, in his hadith he contradicts hafez, and the contradiction among the narrators is no more than two issues. Either the narrator is weak or trustworthy, and if he is weak and contradicts trustworthy or Hafiz, then his hadith is objectionable, and if he is trustworthy and disagreed with the trustworthy, or who is more trustworthy than him, then his hadith is odd. Al-Bukhari has given this word to

seven narrators. The current study shows that all of them are poor and they have contradicted the more trustworthy hafiz.
Lafizat Albahr Fi Alquran Alkrym - Tafsir Waejaz-
Authors: Saed Najlaa , Jamil Razan 
Published: March 2023

ABSTRACT

The Book of Allah is characterized by the fact that it addresses the mind and the soul together, It explains scientific facts and reinforcing them with the main goal of proving the oneness of Allah to those who susbect this.
The scholars are different in the definition of the sea each according to its approach and purpose. In the current research we collected definitions and verses that include the word sea and its derivatives, and we were exposed to the interpretation of selected verses with varying meanings according to the Qur'anic context, as we addressed the scientific miracles of certain verses containing the word, proving scientific facts discovered on the water of the sea later, indicates the oneness of the Creator and the greatest of his making.
Jurisprudence Provisions Related to Reservation
Authors: Hamid Hamid 
Published: March 2023

ABSTRACT

Islamic jurisprudence deals with people's problems and relieves the pain of living. The inquirer about knowledge when researching matters of jurisprudence must delve into the issues that have occurred. I state in the research entitled (Jurisprudential Rulings Related to Stone) about the definition of reservation, the ruling on the emancipation of the bankrupt after reservation , and the settlement of deferred debts by death, and about preventing the debtor from traveling until his rightful owner is documented. Then the conclusion in which I mentioned the most important results that I reached at and may God bless our master Muhammad and his family and companions as a whole.
The Impact of Contextual Connotation on the Investigations of Fundamentalists and the Purposes of Sharia
Authors: Werdee Mushtaq 
Published: March 2023

ABSTRACT

In the course of their books, fundamentalists talked about the connotation of the context and its obvious impact on building the fundamentalist base. Many recent studies have researched the types of this Connotation and its influence on the understanding of texts. Some studies have neglected, according to the researcher, the views of fundamentalists and their jurisprudence in guiding contextual significance, and how they directed this connotation commensurate with the purposes of the Sharia, which called the researcher to indicate the views of fundamentalists and their words in the semantics of the context of the texts of legitimacy, and then build these rules which were developed by scientists and directed guidance to achieve the legitimate purpose behind these provisions. Thuse the research was divided into four chapters:
The first chapter: the definition of connotation language and idiomatic.
The second chapter: the concept of context in the language and the term scientists.
The third chapter: Contextual connotation in the fundamentalists.
The fourth chapter: contextual connotation and the purposes of Sharia.
Fitnah and its Implications in the Holy Qur’an - Term and Approach-
Authors: Musa Musa 
Published: March 2023

ABSTRACT

The source of sedition sometimes comes from Allah Almighty to test the sons of Adam with all their types of prophets, believers, hypocrites and infidels alike, to demonstrate Allah Almighty’s justice, as He tests His Worshippers with various kinds of tests until he distinguishes the bad from the good, or strengthens the faith of some persons. The source of sedition may stem from the Man himself, and from this aspect what is between the infidels and the believers, and what is between the hypocrites and the believers, as a test for some, or a punishment for others, including what is from the side of Satan to man, and other cases. Thus the subject of sedition in the Holy Qur’an is extremely important for its connection with human life.
Interpretation According to the Fundamentalists and its Applications According to the Jurists )Applied Fundamentalist Study(
Authors: Khamis Khaled 
Published: March 2023

The fundamentalists were keen to set controls and restrictions to allow interpretation, to preserve the provisions of this religion, as saying interpretation and opening its doors without restrictions and conditions leads to the spread of corruption and deviation, and disruption in the legal rulings, so here are the misguided sects that have been corrupted only as a result of excessive interpretation, at the same time. Closing the door of interpretation and acting on the apparent meaning of the texts also obstructs the rulings and distances itself from the spirit of legislation.
The reason for choosing this topic is:
1- What the issue of interpretation is of great importance in understanding the requirements and meanings contained in the legal texts, whether in the wise book or in the purified Sunnah.
2 What the interpretation leads to in terms of the vast assimilation of the perceptions and the rich implications contained in these texts.
3- The reality of the shining miracle that is evident in the texts of the Great Qur’an.
The research was divided into four chapters as follows:
The first chapter: The concept of interpretation, its conditions and types according to the fundamentalists, and it contains three topics:
The first topic: the concept of interpretation
The second topic: the conditions of interpretation, and there are two requirements.
The first requirement: interpretation of language and law
The second requirement: the difference between interpretation and interpretation
The third topic: Types of interpretation
Chapter Two: Jurisprudential Applications to Interpretation of the Fundamentalists in the Chapter on Worship, and it contains two topics:
The first topic: the menstruating woman touching the Qur’an
The second topic: Paying the value instead of the eye in zakat
Chapter Three: Jurisprudential Applications to Interpretation of the Fundamentalists in the Chapter of Transactions, which includes two topics The first topic: the choice of the council.
The second topic: the guarantee of the stolen.

Chapter Four: Jurisprudential Applications to Interpretation of the Fundamentalists in the Chapter of Penalties,
Issues of Prophecies in Surah (Sad) an -Objective Study -
Authors: Muhammad Muhammad , Ibrahim Mohammed 
Published: March 2023

Belief in faith based on a belief in God, his angels, his books, and his messengers, and the Last Day, and faith in destiny, its Welfare and its evil, and other, things . Some scholars joined this division, and others went to the division, the triple, which is the third of the pious, the nuances and the audiences.
This study dealt with one of these issues, which is the issue of prophethood, and the study came to show its meaning in language and convention, and the difference between the Prophet and the Messenger, as well as the issues indicated by Surah (Sad).

it dealt with what the surah referred to from the functions of the messengers, their names, numbers, attributes, and characteristics, and what was indicated by them in terms of their virtues, differentials and ranks, may blessings and peace be upon them.
Verses That Crilicize and Praise the Poets In Surat (Al-Shuara) –An Analytical Study-
Authors: Muhammad Zafer 
Published: March 2023

The verses of the Noble Qur’an are the secret of the beauty of Arabic, and its striking charm, where we notice the beauty of his portrayal and the beauty of his expression of huge issues and connotations in a space in which it is impossible for humans to express such purposes in the broadest and most accurate expression with the strange harmony between a statement and its meaning, as is the case of the verses where The poets were criticized and praised, We stood on the secret of miracles in the diversity of the Qur’anic vocabulary that had a prominent role in depicting the Qur’anic meaning, and the linguistic and semantic secrets it contained, as well as the structures that were built from them and the methods in which they were used to clarify their purposes and the purpose for which they were directed, and that is in two sections, The first group deals with the discussion of Qur’anic vocabulary in two groups: the first one talked about the names that are mentioned in them, and the second one: the actual formulas in which they are used. As for the second section: the types of the Qur’anic sentence are separated into two groups, the first: in the defamation of poets, and the second in praising of the poets. Then a conclusion that summarized what have been mentioned.
Hadiths About Eating Hyena Meat in the Sunnah of the Prophet, A Critical Modern Study
Authors: Saeed Khaled , Saleh Abdul Sattar 
Published: March 2023

ABSTRACT

The science of the Prophet’s hadith is one of the most honorable legal sciences, as it is the second revelation after the Noble Qur’an, and the eminent scholars have been interested in everything that would clarify the correct hadith from its bad ones, because of that of a great impact in distinguishing the permissible and the forbidden, The researcher in such science cannot reach to the result closest to the truth except after exhausting the capacity to collect the methods from the various hadith sources, and to know the conditions of men, and to stand on the sayings of the scientist. I have studied in this study the hadiths about eating Hyena meat in the Sunnah of the prophet as a modern critical study in order to know the accurate hadiths which have not yet assured, and without referring to the juris prudential aspect this research. This research includes two topics, the first in the hadiths of the permissibility of eating, and the second in the hadiths that forbid eating.
Introducing Usury of the Six Principals and the Contemporary Issues Arising from it
Authors: Ahmed Abdul Rahman , Hamad Youssef 
Published: March 2023

ABSTRACT

The jurists have defined usury with many definitions, the Hanafis defined it as the credit that is free of conditional consideration in the sale. As for the Malikis, I did not find an independent definition of usury, and I think that it does not exceed the definitions that the scholars came with. Likewise, and as for the definition of the Hanbalis, usury for them is the increase in specific things, and the ruling on usury came in the Book, the Sunnah and the consensus. In the issue, and the reason for the difference in the issue, and then the chosen saying as we see in the light of the discussion of each issue, and we came out with specific results for the research together.
Jurisprudence Rulings Deduced from the Hadith of (Al-Nawa’) and its Contemporary Applications
Authors: Hussein Refaat 
Published: March 2023

ABSTRACT

This research deals with the jurisprudential statement of the hadith Qudsi, the hadith of the Prophet, which is the saying of the polytheists at the time of the pre-Islamic period, our rain: (Ban such-and-such ... and such ...). This research came to separate the jurisprudential rulings related to this hadith, and it appears that the influence of the planets, celestial bodies and stars is one of the pre-Islamic customs that Islam came to contradict and fight it, for there is no influence in the universe except Allah, and that the absolute unseen is known only to the Creator, Owner, Master and Controller of the universe, Glory be to Him. Contemporary astrology and what is permissible and what is forbidden and forbidden.
Affection in Interpretation According to Abi Hayyan Al-Andalusi (d. 745 A.H) Through his Interpretation of Al-Bahr Al-Moheet Surat Al-Baqarah as a Model
Authors: Khalaf Murad , Saleh Nafeh 
Published: March 2023

ABSTRACT

Attributing to interpretation is a synthetic term meaning an attempt to convey the verse to a meaning that the word may carry with the presence of the apparent meaning without a legitimate need And cost in interpretation is a term similar to what is in interpretation and indicative interpretation, as the difference between them is the fulfillment of the conditions of each of them, and then we went back to this research . On knowing the obligatory in the interpretation and we spoke successively about Abu Hayyan Al-Andalus and how he explained and identified the pretentious sayings that he mentioned in his interpretation of Al-Bahr Al-Moheet and then refuting them and clarifying the sayings of the commentators who were charged with the interpretation of some verses.