bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simplified engineering geomorphic unit-based seismic site characterization of the detailed area plan of Dhaka city, Bangladesh
Authors: Hossain Md Shakhawat , Numada Muneyoshi , Mitu Momtahina , Timsina Kishor , Krisna Chaitaniya , Rahman Md. Zillur , Kamal A. S. M. Maksud , Meguro Kimiro 
Published: July 2023

AbstractSevere failure of improperly designed and poorly constructed structures may occur due to the amplified and prolonged ground motion during an earthquake, and hence prediction of the ground motion characteristics at the soil surface is crucial. In this study, based on the prepared simplified engineering geomorphic map, we performed a one-dimensional (1D) nonlinear site response analysis for seismic site characterization of the recently proposed Detailed Area Plan (DAP) area of Dhaka City, the Capital of Bangladesh. The engineering geomorphic unit-based map was prepared from image analysis and verified with the collected borehole data and surface geology map. The study area was classified into three major geomorphic units and seven sub-units subject to the subsurface soil profiles. Nine earthquake time histories, seven from the PEER NGA WEST2 data set and two synthetics, and seven identified subsurface soil profiles were used for nonlinear site response analysis, along with the BNBC 2020 uniform hazard spectrum as the target spectrum. For the selected earthquake ground motions, the near-surface soil response of the DAP area showed de-amplification of acceleration in the short period and amplification of acceleration in the long period. The amplified long-period acceleration could cause severe damage in inappropriately designed and poorly constructed long-period structures. The outcome of this study could be used to prepare a seismic risk-sensitive land use plan for the future development of the DAP of Dhaka City.
ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo
Authors: Nomura Teiko Komori , Endo Satoshi , Kuwano Takuma , Fukasawa Kazuya , Takashima Shigeo , Todo Tomoki , Furuta Kyoji , Yamamoto Takuhei , Hinoi Eiichi , Koyama Hiroko , Honda Ryo 
Published: July 2023

AbstractARL-17477 is a selective neuronal nitric oxide synthase (NOS1) inhibitor that has been used in many preclinical studies since its initial discovery in the 1990s. In the present study, we demonstrate that ARL-17477 exhibits a NOS1-independent pharmacological activity that involves inhibition of the autophagy-lysosomal system and prevents cancer growth in vitro and in vivo. Initially, we screened a chemical compound library for potential anticancer agents, and identified ARL-17477 with micromolar anticancer activity against a wide spectrum of cancers, preferentially affecting cancer stem-like cells and KRAS-mutant cancer cells. Interestingly, ARL-17477 also affected NOS1-knockout cells, suggesting the existence of a NOS1-independent anticancer mechanism. Analysis of cell signals and death markers revealed that LC3B-II, p62, and GABARAP-II protein levels were significantly increased by ARL-17477. Furthermore, ARL-17477 had a chemical structure similar to that of chloroquine, suggesting the inhibition of autophagic flux at the level of lysosomal fusion as an underlying anticancer mechanism. Consistently, ARL-17477 induced lysosomal membrane permeabilization, impaired protein aggregate clearance, and activated transcription factor EB and lysosomal biogenesis. Furthermore, in vivo ARL-17477 inhibited the tumor growth of KRAS-mutant cancer. Thus, ARL-17477 is a dual inhibitor of NOS1 and the autophagy-lysosomal system that could potentially be used as a cancer therapeutic.
Entwicklung eines Selbstauskunftsfragebogens zur Erfassung
stigmatisierender Einstellungen des psychiatrischen Personals gegenüber
Patienten mit Borderline-Persönlichkeitsstörung
Authors: Schäfer Marvin , Luck-Sikorski Claudia , Hochrein Regine , Schomerus Georg , Gollek Sabine 
Published: July 2023

Zusammenfassung
Ziel der Studie Die Entwicklung eines Selbstauskunftfragebogens, zur
quantitativen Erfassung stigmatisierender Einstellungen des psychiatrischen
Personals gegenüber Patienten mit
Borderline-Persönlichkeitsstörung.
Methode Online-Befragung von Psychiatern, Psychologen und
Pflegekräften (n=94) des (teil-) stationären
psychiatrischen Bereichs mit übersetzten Items eines
Einstellungs-Fragebogens, anschließende Hauptkomponentenanalyse und
Korrelation der Hauptkomponenten mit sozialer Distanz.
Ergebnisse Hauptkomponentenanalyse zeigte eine 4-Hauptkomponentenstruktur
mit 63,60% Varianzaufklärung und kleine bis große
Korrelationen zwischen den Hauptkomponenten und sozialer Distanz.
Schlussfolgerung Es können sich initiale Hinweise für
Validität und Reliabilität des entwickelten Fragebogens sowie
Notwendigkeit zusätzlicher Analysen mit größerer
Stichprobe und konfirmatorischer Faktorenanalyse für
weiterführende Fragebogenentwicklung ableiten lassen.
„Aber ohne therapeutische Begleitung, schaffe ich es
nicht“ – Exploration von Erfahrungen von Menschen mit
psychischen Erkrankungen hinsichtlich der Unterstützung bei
ernährungsbezogenen Problemen
Authors: Peisser Anna Maria , Cornet Sebastian , Moerkl Sabrina , Müller-Stierlin Annabel 
Published: July 2023

Zusammenfassung
Ziel der Studie In dieser Studie untersuchten wir die subjektiven
Erfahrungen und Wünsche von Betroffenen in Bezug auf ernährungs-
und gewichtsbezogene Unterstützung im Rahmen der Regelversorgung.
Methodik Insgesamt wurden 16 Interviews mit Erwachsenen mit einer schweren
psychischen Erkrankung anhand eines semi-strukturierten Leitfadens in Ulm
(Deutschland) und Graz (Österreich) durchgeführt und qualitativ
ausgewertet.
Ergebnisse Einige Betroffenen kritisierten die aus ihrer Sicht
unzureichende Unterstützung durch Fachkräfte bei
ernährungs- und gewichtsbezogenen Problemen und wünschen sich
eine stärkere Adressierung dieser Themen in der psychiatrischen
Versorgung.
Schlussfolgerung Die Implementierung von gesundheitsfördernden
Angeboten in der psychiatrischen Versorgung ist wichtig, um eine aus
Betroffenensicht bedürfnisorientierte Versorgung zu schaffen. Durch
interdisziplinäre Versorgungskonzepte könnten
Verantwortlichkeiten diesbezüglich auf mehrere Berufsgruppen verteilt
werden.
Solving non-linear optimization problems by a trajectory approach
Authors: Drezner Zvi , Miklas-Kalczynska Malgorzata 
Published: July 2023

Abstract
Accepted by: Konstantinos Nikolopoulos
We propose solving non-linear optimization problems by a trajectory method. A parameter is introduced into the optimization problem. For example, a variable in the original formulation is replaced by its squared value. The parameter is the power at which the variable is raised. For a particular value of the parameter (power of 2), the optimal solution is easily obtained. The original optimization problem is defined for another value of the parameter (power of 1). As another example, the means and standard deviations of a function based on a set of variables can be calculated. We multiply the standard deviations by a factor (the parameter) between 0 and 1. Suppose that the problem is easily solvable for zero standard deviations (factor of 0). If we ‘slowly’ increase the factor, the solution moves to the desired solution for a factor of 1. A trajectory connects the easily obtained solution to the desired solution. We trace the trajectory and the solution for the optimization problem is at the end of the trajectory. The procedure is applied for solving the single facility Weber location problem, and a competitive location problem with good results.
Effects of Early Versus Delayed Feeding in Patients With Acute Pancreatitis
Authors: Liang Xi-Ying , Wu Xin-An , Tian Ying , Gao Hang , Chen Jing-Jing , Feng Quan-Xin 
Published: July 2023

Background:
The aim of this study was to summarize the optimal strategy for early feeding in patients with acute pancreatitis.

Methods:
The search was undertaken in electronic databases, which compared early with delayed feeding in acute pancreatitis. The primary outcome was the length of hospital stay (LOHS). The second outcomes were intolerance of refeeding, mortality, and total cost of each patient. This meta-analysis followed the “Preferred Reporting Items for Systematic Reviews and Meta-analyses” guideline. Research is registered by PROSPERO, CRD42020192133.

Results:
A total of 20 trials involving 2168 patients were included, randomly assigned to the early feeding group (N = 1033) and delayed feeding group (N = 1135). The LOHS was significantly lower in the early feeding group than the delayed feeding group (mean difference: −2.35, 95% CI: −2.89 to −1.80; P < 0.0001), no matter the mild or severe subgroup (P
int = 0.69). The secondary outcome of feeding intolerance and mortality were no significant difference (risk ratio: 0.96, 0.40 to 2.16, P = 0.87 and 0.91, 0.57 to 1.46, P = 0.69; respectively). Moreover, the hospitalization cost was significantly less in the early feeding group, resulting in an average savings of 50%. In patients with severe pancreatitis, early feeding after 24 hours may be beneficial (P
int = 0.001).

Conclusion:
Early oral feeding can significantly reduce the LOHS and hospitalization costs in patients with acute pancreatitis without increasing feeding intolerance or mortality. In patients with severe pancreatitis, early feeding after 24 hours may be beneficial.
Federated Learning for Diagnosis of Age-related Macular Degeneration
Authors: Gholami Sina , Lim Jennifer I. , Leng Theodore , Ong Sally Shin Yee , Thampson Atalie Carina , Alam Minhaj Nur 
Published: July 2023

AbstractThis paper presents a federated learning (FL) approach to train deep learning models for classifying age-related macular degeneration (AMD) using optical coherence tomography image data. We employ the use of residual networks and vision transformer encoders for the normal vs AMD binary classification, integrating four unique domain adaptation techniques to address domain shift issues caused by heterogeneous data distribution in different institutions. Experimental results indicate that FL strategies can achieve competitive performance similar to centralized models even though each local model has access to a portion of the training data. Notably, Adaptive Personalization FL strategy stood out in our FL evaluations, consistently delivering high performance across all tests due to its additional local model. Furthermore, the study provides valuable insights into the efficacy of simpler architectures in image classification tasks, particularly in scenarios where data privacy and decentralization are critical using both encoders. It suggests future exploration into deeper models and other FL strategies for a more nuanced understanding of these models’ performance.
Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression
Authors: Fagen Sara , Burgess Jeremy D. , Lim Melina , Amerna Danilyn , Kaya Zeynep B. , Faroqi Ayman H. , Perisetla Priyanka , DeMeo Natasha N. , Stojkovska Iva , Quiriconi Drew J. , Mazzulli Joseph R. , Delenclos Marion , Boschen Suelen L. , McLean Pamela J. 
Published: July 2023

AbstractNeuronal inclusions comprised of aggregated alpha-synuclein (αsyn) represent a key histopathological feature of neurological disorders collectively termed “synucleinopathies”, which includes Parkinson’s disease (PD). Mutations and amplifications in theSNCAgene encoding αsyn cause familial forms of PD and a large body of evidence indicate a correlation between αsyn accumulation and disease. Decreasing αsyn expression is recognized as a valid target for PD therapeutics, with down-regulation ofSNCAexpression potentially attenuating downstream cascades of pathologic events. Honokiol (HKL) is a polyphenolic compound derived from magnolia tree bark that has demonstrated neuroprotective properties. Here, we describe potential beneficial effects of HKL on αsyn levels in multiple experimental models. Using human neuroglioma cells stably overexpressing αsyn and mouse primary neurons, we demonstrate that HKL treatment results in a significant decrease in αsyn expression at both the protein and mRNA levels. Our data support a mechanism whereby HKL acts by post-transcriptional modulation ofSNCArather than modulating αsyn protein degradation. Additionally, transcriptional profiling of mouse cortical neurons treated with HKL identified several differentially expressed genes (DEG) as potential targets to modulateSNCAexpression. Overall, these data highlight a viable strategy to reduce αsyn levels, which represents a promising target to modify disease progression in PD and other synucleinopathies. In addition, HKL acts as a powerful tool for investigatingSNCAgene modulation and its downstream effects.
DNA Origami Tension Sensors (DOTS) to study T cell receptor mechanics at membrane junctions
Authors: Hu Yuesong , Duan Yuxin , Velusamy Arventh , Narum Steven , Rogers Jhordan , Salaita Khalid 
Published: July 2023

AbstractThe T cell receptor (TCR) is thought to be a mechanosensor, meaning that it transmits mechanical force to its antigen and leverages the force to amplify the specificity and magnitude of TCR signaling. The past decade has witnessed the development of molecular probes which have revealed many aspects of receptor mechanotransduction. However, most force probes are immobilized on hard substrates, thus failing to reveal mechanics in the physiological context of cell membranes. In this report, we developed DNA origami tension sensors (DOTS) which bear force sensors on a DNA origami breadboard and allow mapping of TCR mechanotransduction at dynamic intermembrane junctions. We demonstrate that TCR-antigen bonds experience 5-10 pN forces, and the mechanical events are dependent on cell state, antigen mobility, antigen potency, antigen height and F-actin activity. We tethered DOTS onto a microparticle to mechanically screen antigen in high throughput using flow cytometry. Finally, DOTS were anchored onto live B cell membranes thus producing the first quantification of TCR mechanics at authentic immune cell-cell junctions.
Factors influencing adoption of green buildings in Tanzania: a qualitative case study
Authors: Mushi Frank Victor , Nguluma Huba , Kihila Jacob 
Published: July 2023

PurposeGreen buildings have proven to be essential contributors to the sustainability of buildings in the construction industry. However, in developing economies, the rate of green building adoption is slow. Moreover, the factors linked to a relatively slow adoption rarely feature in the literature. This study seeks to bridge the gap by first exploring factors influencing the adoption of green buildings. Second, analysing strategies and preferences determining the adoption of green building principles and lastly, exploring case-based opportunities for their adoption in Tanzania.Design/methodology/approachSemi-structured interviews were conducted to collect qualitative data from twelve key informants. The qualitative data were analysed using content analysis.FindingsThe findings indicate that the most influential factors in green building adoption are related to key organizational decisions. Moreover, social and environmental factors are more related to green building adoption than economic factors. In addition, energy and water efficiency are the most commonly adopted sustainability features, while certified materials, recycling and reusing are rarely implemented.Practical implicationsSince green building adoption is still in its infancy, this study informs policymakers, professional bodies, developers, and researchers of the empirically supported factors for green building adoption. The conclusions can be amplified within the sustainability movement.Originality/valueThis study provides an in-depth understanding of the precursors of green building adoption, which is increasingly becoming a paradigm shift in the construction sector. The study is the first to present an in-depth analysis of the real-life factors influencing the adoption of green buildings in Tanzania.
Business hybrid offerings by manufacturing SMEs: impact of servitization on internationalization of manufacturing SMEs
Authors: Chatterjee Sheshadri , Chaudhuri Ranjan , Vrontis Demetris 
Published: July 2023

PurposeThis study examines the significance of the hybrid offerings of servitization by manufacturing small and medium-sized enterprises (SMEs). This study also examines why and how hybrid offerings matter for manufacturing SMEs. The study also investigates the moderating role of risk-taking ability (RA) and technology turbulence (TT) on manufacturing SMEs' performance.Design/methodology/approachThis study has used literature from the areas of servitization, hybrid offerings and internationalization related to SMEs. Also, with the help of theories and literature, a model has been developed conceptually. This model has been validated using a structural equation modeling (SEM) technique on survey data collected from manufacturing SMEs.FindingsThis study finds the significance of manufacturing SMEs' servitization for internationalization effort. Also, this study highlights the moderating impacts of RA and TT on the performance of manufacturing SMEs.Research limitations/implicationsThis study provides valuable inputs to the management of SMEs, especially practitioners that are involved in formulating strategies for hybrid offerings, including servitization activities for the manufacturing SMEs. This study also contributes to the overall body of literature on hybrid offering and servitization.Originality/valueThe study adds values to the overall body of literature for both servitization and internationalization. This study focuses mainly on the significance of hybrid offerings, including servitization by the manufacturing SMEs. Few studies have dealt with such hybrid offerings by manufacturing SMEs as part of the SMEs' internationalization effort. Thus, this study can be considered unique. Moreover, the study investigates the moderating role of RA and TT for SME performance, which adds value toward the body of knowledge in the extant literature.
A gendered multigroup analysis of teachers' in-role and extra-role performance: the effect of time pressure during COVID-19
Authors: Ali Shahzad , Abdul Razak Nor Azam , Hasan-Basri Bakti , Ali Hasnain 
Published: July 2023

PurposeThis study investigated the in-role and extra-role performance of male and female teachers. Multigroup Analysis is applied to the unique combination of independent variable time pressures, mediating variable psychological empowerment and dependent variable teacher in-role and extra-role performance.Design/methodology/approachThe reason for employing a distinctive methodology is because of male and female characteristics. In addition, data were gathered during COVID-19 using convenient sampling techniques from male and female teachers working in Pakistani higher education institutions.FindingsThe results showed that time has a significant impact on how well male and female teachers do their jobs. According to the gendered characteristics, psychological empowerment significantly intervenes between time pressure and teacher performance. Furthermore, the result provides policymakers with guidelines while assigning the task to teachers.Practical implicationsThis article highlighted the issues of performance under time pressure imposed by an educational institution's employer and developed the mechanism for effective and efficient policies to improve the performance of teachers.Originality/valueUnder the lens of the cognitive theory of load, this study contributes to the literature on time pressure, psychological empowerment and teacher performance by introducing a novel concept and novel research framework.
Motivations and commitment to work in the hospitality industry: investigating employee psychology and responsible organizational behaviors
Authors: Camilleri Mark Anthony , Troise Ciro , Morrison Alastair M. 
Published: July 2023

Purpose
A number of hospitality businesses are understaffed and are experiencing severe labor shortages, in various contexts. In many cases, hotels and restaurants are finding it difficult to retain and recruit motivated employees. In this light, this research uses key constructs related to the self-determination theory and integrates them with a responsible human resources management (HRM) measure, to investigate the antecedents of organizational commitment. The underlying objective of this study is to shed light on employee psychology and on responsible organizational behaviors in the hospitality industry.

Design/methodology/approach
Primary data were captured through an online questionnaire distributed via popular LinkedIn groups that represent hospitality employees. A composite-based structural equations modeling approach was used to confirm the reliability and validity of the chosen factors and to shed light on the causal paths of this contribution’s proposed model.

Findings
The results indicate that there are highly significant direct and indirect effects in this study, particularly between extrinsic motivations – organizational commitment and between responsible HRM – organizational commitment. These relationships are mediated by intrinsic motivations.

Research limitations/implications
This contribution advances a robust responsible organizational behavior model comprising responsible HRM, extrinsic rewards, intrinsic motivation and organizational commitment.

Practical implications
This research implies that practitioners ought to incentivize and reward hardworking employees, in a commensurate manner, to offer them great working environments as well as appropriate conditions of employment, to enhance their loyalty, minimize turnover rates and to attract promising talent.

Originality/value
This empirical study incorporates a responsible HRM construct with extrinsic and intrinsic motivations. It confirms that they are significant antecedents of organizational commitment. Unlike previous research, this contribution focuses on employee psychology as well as on strategic organizational behaviors during a time when tourism businesses are experiencing an increase in demand for their services, in the aftermath of the COVID-19 pandemic. It raises awareness on the industry’s perennial challenges in attracting and retaining employees.
18F‐FDG PET/CT predicts the role of neoadjuvant immunochemotherapy in the pathological response of esophageal squamous cell carcinoma
Authors: Wang Shuohua , Di Shouyin , Lu Jing , Xie Shun , Yu Zhenyang , Liang Yingkui , Gong Taiqian 
Published: July 2023

AbstractBackgroundThis study aimed to investigate the predictive value of 18F‐FDG PET/CT for pathological response after neoadjuvant immunochemotherapy (NICT) in patients with esophageal squamous cell carcinoma (ESCC).MethodsThe clinical data of 54 patients with ESCC who underwent two cycles of NICT followed by surgery were retrospectively analyzed. NICT consisted of PD‐1 blockade therapy combined with chemotherapy. 18F‐FDG PET/CT scans were performed before and after NICT. The pathological results after surgery were used to assess the degree of pathological response. The scan parameters of 18F‐FDG PET/CT and their changes before and after NICT were compared with the pathological response.ResultsAmong the 54 patients, 10 (18.5%) achieved complete pathological response (pCR) and 21 (38.9%) achieved major pathological response (MPR). The post‐NICT scan parameters and their changes were significantly associated with the pathological response. In addition, the values of the changes in the scanned parameters before and after treatment can further predict the pathological response of the patient.Conclusion18F‐FDG PET/CT is a useful tool to evaluate the efficacy of NICT and predict pathological response in patients with ESCC. The post‐NICT scan parameters and their changes can help identify patients who are likely to achieve pCR or MPR.