bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibitory effect of Bofutsushosan (Fangfengtongshengsan) extract on the absorption of fructose in rats and mice
Authors: Takagi Kohei , Sugihira Takashi , Kitamura Miho , Kawai Mami , Mitsuguchi Yoko , Tsukamoto Kosei , Nakanishi Hirofumi , Makino Toshiaki 
Published: April 2023

AbstractBofutsushosan (BTS; fangfengtongshengsan in Chinese) is a formula in traditional Japanese Kampo and Chinese medicine comprising 18 crude drugs and used to treat obesity and metabolic syndrome. In our previous study, BTS boiling water extract inhibited the uptake of fructose absorbed via glucose transporter 5 into cultured cells. In this study, the inhibitory effect of BTS extract on the absorption of fructose from the intestine was investigated in vivo. The extract of BTS was orally administered to rats at doses equivalent to 25-fold of the daily dose for humans. One minute after sample administration, fructose was orally administered and blood samples were collected from the jugular vein 0.5, 1, 1.5, 2, and 4 h after the administration of fructose. The absorption of fructose from the intestine was significantly reduced by treatment with BTS extract, and this in vivo study reproduced previous in vitro results. Subsequently, the blood samples were collected from the portal vein 30 min after the oral administration of fructose in mice. BTS extract significantly reduced fructose absorption in mice, and compared the effect of modified BTS samples by removing one to several crude drugs from BTS. We found that the dried rhizome of Rheum palmatum (RR) significantly contributed to the inhibitory effect of BTS on fructose absorption. We found sennoside A to be the active ingredient of RR for the inhibition of fructose absorption, and that its effect almost saturated at a dose of 3 mg/kg. These results support the action mechanisms of BTS when used for the treatment of obesity in clinics and drug stores.
Graphical abstract
Towards the concept of gas-to-power demand response
Authors: Hilbert Markus , Kleine Andreas , Dellnitz Andreas 
Published: April 2023

AbstractDue to the war in Ukraine, the European Commission has released its “Save Gas for a Safe Winter” plan, communicating the goal of reducing gas consumption in the electricity sector, among others. In this paper, the gas consumption in the electricity sector is picked up and the well-established concept of demand response is brought into alignment with the consumption of gas in the electricity sector, leading to the concept of gas-to-power demand response. Two proposed programs based on this concept are then applied in a production planning approach that shows how companies could proactively contribute to easing the tense situation in Europe, particularly in Germany, especially using methods such as scheduling and/or lot-sizing. This article is intended to serve as a basis for further discussions in the political and economic sectors.
Technology of Standard SMT Components Embedded Into PCB by Using Different Materials as Filling Masses
Authors: Stęplewski Wojciech , Rybak Andrzej , Dziedzic Andrzej , Bialas Marcin , Wojcik Mariusz , Ostaszewski Dariusz , Ramotowski Edward , Janeczek Kamil , Chołaj Aneta , Kościelski Marek , Sitek Anna , Liszewska Dorota 
Published: April 2023

AbstractThe technique of embedding components inside printed circuit boards (PCBs) is described, using different filling masses. To investigate the possibility of placing the components inside the printed circuit board, a residual circuit breaker with an overload protection (RCBO) system was adapted. Four types of fillings (two epoxy and two silicone) were used in the tests, which were carried out showing the full functionality of the systems embedded in the PCB, regardless of the applied sealing compound. A certain disadvantage was the shrinkage of the applied masses, which was visible in some cases in the occurrence of gaps in the flooding spaces. However, it should be emphasized that the tests were preliminary and that the adjustment of the filling shrinkage will be optimized in subsequent tests.
Cell death in the lateral geniculate nucleus, and its possible relationship with nicotinic receptors and sudden infant death syndrome (SIDS)
Authors: Chang Cynthia , Vivekanandarajah Arunnjah , Waters Karen A , Machaalani Rita 
Published: April 2023

AbstractThe role of the lateral geniculate nucleus (LGN) in vision has been extensively studied, yet its extraretinal capacities are still being investigated, including its role in arousal from sleep. The β2 nicotinic acetylcholine receptor (nAChR) subunit is involved in the laminal organisation of the LGN with magnocellular (MC) and parvocellular (PC) neurons. Sudden infant death syndrome (SIDS) occurs during a sleep period and, neuropathologically, is associated with increased neuronal cell death and altered nAChRs. A recent qualitative pilot study from our group implicates the possibility of increased neuronal death/apoptosis in the SIDS LGN. The present study used quantitative analysis to report the baseline expression of apoptotic and nAChR subunits α7 and β2 in the PC and MC layers of the LGN, to determine correlations amongst these markers within layers and across layers, and to evaluate changes in the expression of these markers in the LGN of SIDS infants, along with associations with SIDS risk factors, such as age, sex, cigarette smoke exposure, bed-sharing, and presence of an upper respiratory tract infection (URTI). Tissue was immunohistochemically stained for cell death markers of active caspase-3 (Casp-3) and TUNEL, and for the α7 and β2 nAChR subunits. Amongst 43 cases of sudden and unexpected deaths in infancy (SUDI), classifications included explained deaths (eSUDI, n = 9), SIDS I (n = 5) and SIDS II (n = 29). Results indicated a strong correlation of the apoptotic markers and β2 nAChR subunit between the LGN layers, but not across the markers within the layers. Amongst the diagnostic groups, compared to eSUDI, the SIDS II cases had decreased Casp-3 expression while β2 nAChR expression was increased in both PC and MC layers. Amongst the SIDS risk factors, URTI and bed-sharing were associated with changes in neuronal death but not in the α7 and β2 markers. In conclusion, our findings do not support a role for the α7 and β2 nAChRs in apoptotic regulation of the LGN layers during infancy. However, for SIDS victims, an inverse correlation between the changes for markers of apoptosis and the β2 nAChR subunit expression suggests altered LGN function.
Looking for an Objective Parameter to Identify Early Vocal Dysfunctions in Healthy Perceived Singers
Authors: Longo Lucia , Angeletti Diletta , Parrinello Silvia , Cilfone Armando , Giliberti Claudia , Mariconte Raffaele 
Published: April 2023

AbstractThe finding of minimal laryngeal dysfunctions in professional voice users is essential to prevent the onset of organic vocal pathologies. The purpose of this study is to identify an objective parameter that supports the phoniatric evaluation in detecting minimal laryngeal dysfunctions in singers. 54 professional and non-professional singers have been evaluated with laryngostroboscopy, Multi-Dimensional Voice Program (MDVP), Dysphonia Severity Index (DSI), maximum phonation time (TMF), minimum intensity of sound emission (I-min), maximum frequency (F-max), voice handicap index (VHI), singing voice handicap index (SVHI), manual phonogram and audiometric examination. The SVHI of all the “healthy” singers was on average 23.7 ± 22.5, while that of the “dysfunctional” 20.9 ± 18. No statistically significant difference was found between the SVHI scores of the total of healthy singers compared to the scores of the dysfunctional ones on the VSL (p = 0.6). The between-group comparison of the means of individual parameter values of DSI, TMF, F-max, Jitter, Shimmer, NHR, and SPI was not statistically significant (respectively p = 0.315, 0.2, 0.18, 0.09, 0.2, 0.08, 0.3). The only parameter analyzed that was statistically significant was the I-min (p < 0.05). SVHI is a valid instrument for the evaluation after a therapy but in our experience, it is not useful in distinguishing healthy from dysfunctional patients. The minimum intensity of sound emission measured with the sound level meter (I-low2) resulted a reliable parameter to identify minimal laryngeal dysfunctions and a useful tool in supporting the phoniatric diagnostic-therapeutic process in singers.
J-ACCESS investigation and nuclear cardiology in Japan: implications for heart failure
Authors: Nakajima Kenichi , Nishimura Tsunehiko 
Published: April 2023

AbstractWhile coronary heart disease remains a global cause of mortality, the prevalence of heart failure (HF) is increasing in developed countries including Japan. The continuously increasing aging population and the relatively low incidence of ischemic origins are features of the HF background in Japan. Information about nuclear cardiology practice and prognosis has accumulated, thanks to the multicenter prognostic J-ACCESS investigations (Series 1‒4) over two decades in Japan. Although the rate of hard cardiac events is lower in Japan than in the USA and Europe, similar predictors have been identified as causes of major adverse cardiac events. The highest proportion (50–75%) of major events among patients indicated for nuclear cardiology examinations in the J-ACCESS registries is severe HF requiring hospitalization. Therefore, the background and the possible reasons for the higher proportion of severe HF events in Japan require clarification. Combinations of age, myocardial perfusion defects, left ventricular dysfunction, and comorbid diabetes and chronic kidney disease are major predictors of cardiovascular events including severe HF. Although the Japanese Circulation Society has updated its clinical guidelines to incorporate non-invasive imaging modalities for diagnosing chronic coronary artery disease, the importance of risk-based approaches to optimal medical therapy and coronary revascularization is emphasized herein.
Quasicrystals and art: interesting new facts
Authors: Makovicky Emil 
Published: April 2023

AbstractQuasiperiodic ornamental patterns represent only a small percentage of patterns when compared to the entire body of periodic patterns. Decagonal pattern is known since twelfth century Iran and fourteenth century western Islam (Andalusia and Morocco). A rich spectrum of octagonal patterns exists at the latter localities (fourteenth century and later), whereas a sole example of a dodecagonal pattern comes from Morocco. Later copies exist in all these regions. My most recent studies were concentrated upon the Andalusian and Moroccan regions, in which the fourteenth century (and later) wall mosaics occur as uninterrupted coatings of entire walls so that the motif of individual panels had to be adjusted to secure continuity of their underlying bar-and-band structure. In Andalusia, the tetragonal structure of the panels and their complexes were locally adjusted to become octagonal quasiperiodic. Only two geometric types of such octagrids were derived in Andalusia, in agreement with the rarity of quasiperiodic ornaments in general. In Morocco, before the panel substructure became heavily masked by an overflow of rosettes of several sizes, the mosaic panel was based on an octagonal quasiperiodic grid and ornamental rosettes were placed in it, disposed in the form of concentric octagons. As a prominent example, the octagonal motif of the Nejjarine Fountain and its plaster encasement will be discussed.
Facies framework and depositional setting of the Middle-Upper Eocene Hamra Formation, north of Bahariya Oasis, Western Desert, Egypt
Authors: Khalifa Mohamed Abdelghany , Mashaal Noha Mohamed 
Published: April 2023

AbstractThe Middle-Upper Eocene Hamra Formation, covering the northern plateau of the Bahariya Oasis, northwestern Desert, comprises two informal (lower and upper) members; the lower member (Upper Middle Eocene, 34.5-m thick) is made up entirely of fossiliferous limestone rocks (Nummulites gizehensis, Nummulites champolioni), while the upper member (Late Eocene, 38-m thick) consists of an intercalation of limestone with thin beds of sandstone, siltstone, and claystone. The upper member is highly fossiliferous with Turrittella, Carolia palcnoids, and Ostrea multicostata. Seven carbonate and three clastic microfacies have been recognized in five measured sections of the Hamra Formation. The carbonate microfacies were deposited on the proximal ramp setting of a warm and shallow sub-tropical environment. The lower member can be correlated with the (Upper Middle Eocene) Sath El Hadid and Fashn formations, while the upper member is correlated with the Upper Eocene Beni Sueif Formation. The reduced thickness of both members of the Hamra Formation compared with the corresponding rock units to the east reflects the structural uplift prevailed in the north of Bahariya Oasis during sedimentation.
Prospective Association of High Effort and Low Reward Imbalance at Work with Risk of Diabetes: A Cohort Study in US Workers
Authors: Wege Natalia , Siegrist Johannes , Li Jian 
Published: April 2023

Abstract
Background
The contribution of psychosocial stress in the workplace to development of type 2 diabetes mellitus (T2DM) is not well investigated. As most studies were conducted in Europe, a further test from the USA seems well justified. The objective of the current investigation was to examine prospective associations of work stress based on the effort-reward imbalance model with risk of T2DM in a national sample of US workers.

Method
Using data from the national population-based Mid-life in the United States (MIDUS) study with a prospective cohort design and a 9-year follow-up period, the effects of a ratio combining data on effort and reward at work (ER ratio) at baseline on risk of T2DM at follow-up were examined in 1493 workers who were free from diabetes at the baseline survey, applying multivariable Poisson regression analysis.

Results
During the follow-up, 109 individuals (7.30%) reported onset of diabetes. The analyses demonstrated a significant association between continuous data of the E-R ratio and risk of diabetes (RR and 95% CI = 1.22 [1.02, 1.46]), after adjustment for modifiable and non-modifiable risk factors at baseline. A dose-dependent response was observed with trend analysis when using quartiles of the E-R ratio.

Conclusion
In the US workers, high effort in combination with low reward at work was significantly associated with elevated risk of T2DM 9 years later. The risk profiles of diabetes should be adapted in consideration of psychosocial work environment and taken into account by conceptualizing prevention programs of chronic non-communicable diseases.
ACPSEM position paper on ROMP scope of practice and staffing levels for magnetic resonance linear accelerators
Authors: Marsh Linda , Rykers Kym , Sobolewski Matthew ,   the Magnetic Resonance Imaging Linac Working Group (MRILWG) of the ACPSEM
Published: April 2023

AbstractThe purpose of this position paper is to outline the ACPSEM recommendations on Medical Physicist scope of practice and staffing levels, as they relate to the use of dedicated MRI-Linacs in the treatment of patients. A core function of Medical Physicists is to safely implement changes in medical practice via the introduction of new technology and to ensure high quality radiation oncology services are provided to patients. Determining the feasibility of MRI-Linacs in any existing setting, or in establishing a new site, mandates the knowledge and services of Radiation Oncology Medical Physicists (ROMPs) as the Qualified Experts within this setting. ROMPs are key members of the multi-disciplinary team which will be required to steer the successful establishment of MRI Linac infrastructure within departments. To support efficient implementation, ROMPs must be embedded in the process from the start, including any feasibility study, initiation of the project, and development of the business case. ROMPs must be retained throughout all stages of acquisition, service development, and ongoing clinical use and expansion. The number of MRI-Linacs in Australia and New Zealand is growing. This expansion is occurring in parallel with rapid technological evolution, expanding tumour stream applications, and increasing consumer uptake. Growth and applications of MRI-Linac therapy will continue to occur beyond current known horizons, via development on the MR-Linac platform itself and through the migration of learning from this platform to conventional Linacs (known horizons for example include the use of daily, online image guided adaptive radiotherapy and MRI data informing decision making for planning and treatment before and throughout treatment courses). Clinical use, research and development will be a significant component of expanding patient access to MRI-Linac treatment and there will be an ongoing need to attract and retain ROMPs to initially establish services and in particular to drive service development and delivery for the life of the Linacs. MRI and Linac technologies mean it is necessary to perform a specialized workforce assessment for these devices, distinct from those employed for conventional Linacs and associated services. MRI-Linacs are complex, have a heightened risk profile compared to standard Linacs, and are unique in their treatment of patients. Accordingly, the workforce needs for MRI-Linacs are greater than for standard Linacs. To ensure safe and high-quality Radiation Oncology patient services are provided, it is recommended that staffing levels should be based on the 2021 ACPSEM Australian Radiation Workforce model and calculator using the MRI-Linac specific ROMP workforce modelling guidelines outlined in this paper. The ACPSEM workforce model and calculator are closely aligned with other Australian/New Zealand and international benchmarks.
Socioeconomic Inequalities and Ethnic Discrimination in COVID-19 Outcomes: the Case of Mexico
Authors: Salas-Ortiz Andrea 
Published: April 2023

AbstractIn Mexico, Indigenous people were hospitalised and killed by COVID-19 at a disproportionate rate compared to the non-Indigenous population. The main factors contributing to this were poor health conditions and impoverished social and economic circumstances within the country. The objective of this study is to examine the extent to which ethnic disparities are attributable to processes of structural discrimination and further explore the factors that exacerbate or mitigate them. Using administrative public data on COVID-19 and Census information, this study uses the Oaxaca-Blinder decomposition method to examine the extent to which disparities are illegitimate and signal discrimination against Indigenous people. The results show that although ethnic disparities were mainly attributable to observable differences in individual and contextual characteristics, 22.8% (p < 0.001) of the ethnic gap in hospitalisations, 17.5% in early deaths and 16.4% in overall deaths remained unexplained and could potentially indicate systemic discrimination. These findings highlight that pre-existing and longstanding illegitimate disparities against Indigenous people jeopardise the capacity of multi-ethnic countries to achieve social justice in health.
Skin Pigmentation Impacts the Clinical Diagnosis of Wound Infection: Imaging of Bacterial Burden to Overcome Diagnostic Limitations
Authors: Johnson Jonathan , Johnson Alton R. , Andersen Charles A. , Kelso Martha R. , Oropallo Alisha R. , Serena Thomas E. 
Published: April 2023

AbstractUnderrepresentation of diverse skin tones in medical education and providers’ implicit racial bias drives inequities in wound care, such as disproportionally poor outcomes for Black patients. Diagnostic indicators (e.g., erythema) can present differently depending on skin pigmentation. This post hoc analysis of 350 chronic wounds from a prospective 14-site clinical trial aimed to determine how the perception of clinical signs and symptoms of infection (CSS) differs by patient skin tone and if fluorescence-imaging can offer a more objective diagnostic solution. Participants were grouped by skin tone (low, medium, high) as measured by the Fitzpatrick Skin Phototype Classification (FSPC) scale. CSS and total bacterial load (TBL) were compared across FSPC groups, along with sensitivity to detect TBL >104 CFU/g using CSS alone and combined with fluorescence-imaging. Erythema was reported less often with increasing FSPC score (p = 0.05), from 13.4% (low), to 7.2% (medium), to 2.3% (high), despite comparable bacterial loads (median = 1.8 × 106 CFU/g). CSS sensitivity in the high group (2.9%) was 4.8-fold to 8.4-fold lower than the low (p = 0.003) and medium groups (p = 0.04). Fluorescence-imaging significantly improved the detection of high bacterial load in each group, peaking in the high group at 12-fold over CSS alone. These findings underscore the threat of pervasive racialized health inequities in wound care, where missed diagnosis of pathogenic bacteria and infection could delay treatment, increasing the risk of complications and poor outcomes. Fluorescence-imaging is poised to fill this gap, at least in part, serving as a more objective and equitable indicator of wound bacteria. Clinicaltrials.gov#NCT03540004 registered 16-05-2018.
Flight risk evaluation based on flight state deep clustering network
Authors: Wang Guozhi , Xu Haojun , Pei Binbin , Cheng Haoyu 
Published: April 2023

AbstractFlight risk evaluation based on data-driven approach is an essential topic of aviation safety management. Existing risk analysis methods ignore the coupling and time-variant characteristics of flight parameters, and cannot accurately establish the mapping relationship between flight state and loss-of-control risk. To deal with the problem, a flight state deep clustering network (FSDCN) model was proposed to mine latent loss-of-control risk information implicating in raw flight parameters. FSDCN integrates the feature extraction and clustering into an end-to-end deep hybrid network to extract latent risk features from multivariate time-series flight parameters and cluster them. In the FSDCN model, a sequential multi-attention encoder–decoder network is designed to extract embedded risk features, and the feature clustering layer is designed to iteratively refine clustering effects and feature extraction. Besides, a loss-of-control classifier is added to optimize the risk feature vector expression and ensure sufficient dividing feature for facilitate clustering. The multi-task joint learning strategy is adopted to improve the clustering performance of the model further. According to extracted risk features and similarity metrics, the optimal clusters number of flight states is set as 5. Comparative experiments show that FSDCN significantly performs better than other clustering models with performance percentage error below $$6\%$$

6
%

. Through statistical analysis of clustering results, the risk level is quantified for each cluster. Three high-difficulty maneuver cases are presented to demonstrate FSDCN for flight risk evaluation. The flight parameter sequences of the maneuver cases are input into the well-trained FSDCN to obtain the risk prediction results. The spatiotemporal distribution characteristics of the risk-quantized results are consistent with flight parameters over-limit situations, which demonstrates the effectiveness of FSDCN on clustering flight states. The experimental results on flight maneuver cases show that FSDCN can find potential loss-of-control risk features according to multivariate time-series flight data and provide support for in-flight risk warnings.