bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responses of 2DOF Sliding Base Systems Under Harmonic Ground Motions
Authors: Hu Hong-Song 
Published: August 2023

AbstractAlthough actual structures would not be subjected to harmonic ground motions, theoretical solutions obtained under harmonic ground motions can often provide useful information for understanding the mechanism of the structures considered. For this reason, this chapter focuses on the responses of 2-degree-of-freedom (2DOF) sliding base (SB) systems subjected to harmonic ground motions. The main contents of the present chapter include the typical response histories of a 2DOF SB system subjected to harmonic ground motions, the influence of the critical parameters on the maximum structural responses, and the derivation and interpretation of the available theoretical solutions.
Peak Superstructure Responses of Single-Story Sliding Base Structures Under Earthquake Excitation
Authors: Hu Hong-Song 
Published: August 2023

AbstractCompared to multistory sliding base (SB) structures, single-story SB structure is simple and suitable for acquiring the critical parameters influencing the structural response. For this reason, this chapter focuses on the peak superstructure responses of single-story SB structures subjected to three-component earthquake excitation. The influence of the vertical earthquake component and various structural and ground motion characteristics on the peak superstructure response are investigated, and simplified design equations are developed. The developed equations also lay a foundation for the design of multistory SB structures, which will be discussed in the next chapter.
Peak Sliding Displacements of Sliding Base Structures Under Earthquake Excitation
Authors: Hu Hong-Song 
Published: August 2023

AbstractTo ensure the safety of sliding base (SB) structures, the peak sliding displacement (PSD) should not exceed the predetermined sliding displacement threshold. Therefore, the PSD is an important response quantity that should be evaluated in design. In this chapter, the probability distribution of the PSD at a given level of ground motion intensity, and the influence of the vertical earthquake component and various structural and ground motion characteristics on the PSD are investigated. Simplified equations for estimating the PSD are also developed for design purposes.
Non-supersymmetric vacua and self-adjoint extensions
Authors: Mourad J. , Sagnotti A. 
Published: August 2023

Abstract
Internal intervals spanned by finite ranges of a conformal coordinate z and terminating at a pair of singularities are a common feature of many string compactifications with broken supersymmetry. The squared masses emerging in lower-dimensional Minkowski spaces are then eigenvalues of Schrödinger-like operators, whose potentials have double poles at the ends of the intervals. For one-component systems, the possible self-adjoint extensions of Schrödinger operators are described by points in AdS3 × S1, and those corresponding to independent boundary conditions at the ends of the intervals by points on the boundary of AdS3. The perturbative stability of compactifications to Minkowski space time depends, in general, on these choices of self-adjoint extensions. We apply this setup to the orientifold vacua driven by the “tadpole potential” $$ V=T\ {e}^{\frac{3}{2}\phi } $$
V
=
T

e

3
2

ϕ

and find, in nine dimensions, a massive scalar spectrum, a unique choice of boundary conditions with stable tensor modes and a massless graviton, and a wide range of choices leading to massless and/or massive vector modes.
Tests of the Charge Convexity Conjecture in Caswell-Banks-Zaks theory
Authors: Aharony Ofer , Breitstein Yacov-Nir 
Published: August 2023

Abstract
The Charge Convexity Conjecture (CCC) states that in a unitary conformal field theory in d ≥ 3 dimensions with a global symmetry, the minimal dimension of operators in certain representations of the symmetry, as a function of the charge q of the representation (or a generalized notion of it), should be convex. More precisely, this was conjectured to be true when q is restricted to positive integer multiples of some integer q0. The CCC was tested on a number of examples, most of which are in d < 4 dimensions, and its version in which q0 is taken to be the charge of the lowest-dimension positively-charged operator was shown to hold in all of them.In this paper we test the conjecture in a non-trivial example of a d = 4 theory, which is the family of Caswell-Banks-Zaks IR fixed points of SU(Nc) gauge theory coupled to Nf massless fermions and Ns massless scalars. In these theories, the lowest-dimension gauge-invariant operators that transform non-trivially under the global symmetry are mesons. These may consist of two scalars, two fermions or one of each.We find that the CCC holds in all applicable cases, providing significant new evidence for its validity, and suggesting a stronger version for non-simple global symmetry groups.
Vector Superstrata
Authors: Čeplak Nejc 
Published: August 2023

Abstract
We present the construction of several microstate geometries of the supersymmetric D1-D5-P black hole in which, within six-dimensional supergravity, the momentum charge is carried by a vector field. The fully backreacted geometries are smooth and horizonless: they are asymptotically AdS3 × S3 with an AdS2 throat that smoothly caps off. We propose a holographic dual for these bulk solutions and discuss their extension to asymptotically flat space. In addition, we present several uplifts of the full six-dimensional supersymmetric ansatz to ten-dimensions. In particular, we show that there exists a frame in which geometries based on vector field momentum carriers are entirely in the NS-NS sector, making them possible starting points for the exploration of stringy black-hole microstates.
Patientenveranstaltungen in der deutschen Urologie: Trend zu Hybridformaten?
Authors: Karschuck Philipp , Müller Laura , Groeben Christer , Aksoy Cem , Flegar Luka , Zacharis Aristeidis , Baunacke Martin , Wülfing Christian , Huber Johannes 
Published: August 2023

Zusammenfassung
Hintergrund und Fragestellung
Patientenveranstaltungen sind ein wichtiges Instrument, um auf das steigende Bedürfnis der Öffentlichkeit nach Gesundheitsinformationen zu reagieren. Hierfür bietet die Deutsche Gesellschaft für Urologie e. V. (DGU) auf ihren Jahreskongressen das „Patientenforum“ an. Ziel der Arbeit war die Evaluation der Veranstaltungen in den Jahren 2017 bis 2019 und ein Vergleich mit dem ersten digitalen Patientenforum 2020.

Material und Methoden
Anhand eines zweiseitigen, standardisierten Fragebogens befragten wir die Besucher*innen der Präsenzpatientenforen (Präsenzgruppe = P) der drei Jahreskongresse der DGU 2017–2019 sowie die Nutzer*innen des digitalen Angebots 2020 (Onlinegruppe = O).

Ergebnisse
Für die Jahre 2017–2019 erhielten wir n = 71 und für 2020 n = 18 Datensätze. Das mediane Alter der Besucher*innen lag bei 64 (Spannweite 30–89) Jahren. Männlich waren 66 % (P) vs. 83 % (O) der Teilnehmer*innen (p = 0,005). Das Angebot wurde von beiden Gruppen gleichermaßen insgesamt als gut bis sehr gut bewertet, d. h. in Schulnoten 1,6 (P) vs. 1,6 (O; p = 0,7). Die Möglichkeit Fragen zu stellen wurde entsprechend der geringeren Interaktion im digitalen Format in Schulnoten mit 1,5 (P) vs. 2,8 (O) schlechter bewertet (p = 0,003). Auf die Frage nach dem zukünftig gewünschten Veranstaltungsformat sprachen sich die Nutzer des digitalen Patientenforums mit zwei Dritteln für eine Hybridveranstaltung vor Ort und online aus.

Schlussfolgerung
Patientenveranstaltungen eignen sich als Kommunikationsform für die Öffentlichkeit und werden von den Besucher*innen gut bewertet. Insbesondere die direkte Interaktion mit Expert*innen hat hier einen hohen Stellenwert. Präsenzformate sind mit einem hohen logistischen Aufwand sowie hohen Kosten verbunden und ihre Reichweite ist limitiert. Zukünftig können Hybridformate eine sinnvolle Alternative sein, da sie die Vorteile von Online- und Präsenzformaten kombinieren.
Preclinical and clinical pharmacology of brexanolone (allopregnanolone) for postpartum depression: a landmark journey from concept to clinic in neurosteroid replacement therapy
Authors: Reddy Doodipala Samba , Mbilinyi Robert H. , Estes Emily 
Published: August 2023

AbstractThis article describes the critical role of neurosteroids in postpartum depression (PPD) and outlines the landmark pharmacological journey of brexanolone as a first-in-class neurosteroid antidepressant with significant advantages over traditional antidepressants. PPD is a neuroendocrine disorder that affects about 20% of mothers after childbirth and is characterized by symptoms including persistent sadness, fatigue, dysphoria, as well as disturbances in cognition, emotion, appetite, and sleep. The main pathology behind PPD is the postpartum reduction of neurosteroids, referred to as neurosteroid withdrawal, a concept pioneered by our preclinical studies. We developed neurosteroid replacement therapy (NRT) as a rational approach for treating PPD and other conditions related to neurosteroid deficiency, unveiling the power of neurosteroids as novel anxiolytic-antidepressants. The neurosteroid, brexanolone (BX), is a progesterone-derived allopregnanolone that rapidly relieves anxiety and mood deficits by activating GABA-A receptors, making it a transformational treatment for PPD. In 2019, the FDA approved BX, an intravenous formulation of allopregnanolone, as an NRT to treat PPD. In clinical studies, BX significantly improved PPD symptoms within hours of administration, with tolerable side effects including headache, dizziness, and somnolence. We identified the molecular mechanism of BX in a neuronal PPD-like milieu. The mechanism of BX involves activation of both synaptic and extrasynaptic GABA-A receptors, which promote tonic inhibition and serve as a key target for PPD and related conditions. Neurosteroids offer several advantages over traditional antidepressants, including rapid onset, unique mechanism, and lack of tolerance upon repeated use. Some limitations of BX therapy include lack of aqueous solubility, limited accessibility, hospitalization for treatment, lack of oral product, and serious adverse events at high doses. However, the unmet need for synthetic neurosteroids to address this critical condition supersedes these limitations. Recently, we developed novel hydrophilic neurosteroids with a superior profile and improved drug delivery. Overall, approval of BX is a major milestone in the field of neurotherapeutics, paving the way for the development of novel synthetic neurosteroids to treat depression, epilepsy, and status epilepticus.
Graphical abstract
Limiting Behavior of Random Attractors of Stochastic Supercritical Wave Equations Driven by Multiplicative Noise
Authors: Chen Zhang , Wang Bixiang 
Published: August 2023

AbstractThis paper deals with the limiting behavior of random attractors of stochastic wave equations with supercritical drift driven by linear multiplicative white noise defined on unbounded domains. We first establish the uniform Strichartz estimates of the solutions with respect to noise intensity, and then prove the convergence of the solutions of the stochastic equations with respect to initial data as well as noise intensity. To overcome the non-compactness of Sobolev embeddings on unbounded domains, we first utilize the uniform tail-ends estimates to truncate the solutions in a bounded domain and then employ a spectral decomposition to establish the pre-compactness of the collection of all random attractors. We finally prove the upper semicontinuity of random attractor as noise intensity approaches zero.
Non-concave Expected Utility Optimization with Uncertain Time Horizon
Authors: Dehm Christian , Nguyen Thai , Stadje Mitja 
Published: August 2023

AbstractWe consider an expected utility maximization problem where the utility function is not necessarily concave and the time horizon is uncertain. We establish a necessary and sufficient condition for the optimality for general non-concave utility function in a complete financial market. We show that the general concavification approach of the utility function to deal with non-concavity, while being still applicable when the time horizon is a stopping time with respect to the financial market filtration, leads to sub-optimality when the time horizon is independent of the financial risk, and hence can not be directly applied. For the latter case, we suggest a recursive procedure which is based on the dynamic programming principle. We illustrate our findings by carrying out a multi-period numerical analysis for optimal investment problem under a convex option compensation scheme with random time horizon. We observe that the distribution of the non-concave portfolio in both certain and uncertain random time horizon is right-skewed with a long right tail, indicating that the investor expects frequent small losses and a few large gains from the investment. While the (certain) average time horizon portfolio at a premature stopping date is unimodal, the random time horizon portfolio is multimodal distributed which provides the investor a certain flexibility of switching between the local maximizers, depending on the market performance. The multimodal structure with multiple peaks of different heights can be explained by the concavification procedure, whereas the distribution of the time horizon has significant impact on the amplitude between the modes.
TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors
Authors: Sauer Natalia , Janicka Natalia , Szlasa Wojciech , Skinderowicz Bartłomiej , Kołodzińska Katarzyna , Dwernicka Wioletta , Oślizło Małgorzata , Kulbacka Julita , Novickij Vitalij , Karłowicz-Bodalska Katarzyna 
Published: August 2023

AbstractT-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) expression has been a trending topic in recent years due to its differential expression in a wide range of neoplasms. TIM-3 is one of the key immune checkpoint receptors that interact with GAL-9, PtdSer, HMGB1 and CEACAM1. Initially identified on the surface of T helper 1 (Th1) lymphocytes and later on cytotoxic lymphocytes (CTLs), monocytes, macrophages, natural killer cells (NKs), and dendritic cells (DCs), TIM-3 plays a key role in immunoregulation. Recently, a growing body of evidence has shown that its differential expression in various tumor types indicates a specific prognosis for cancer patients. Here, we discuss which types of cancer TIM-3 can serve as a prognostic factor and the influence of coexpressed immune checkpoint inhibitors, such as LAG-3, PD-1, and CTLA-4 on patients' outcomes. Currently, experimental medicine involving TIM-3 has significantly enhanced the anti-tumor effect and improved patient survival. In this work, we summarized clinical trials incorporating TIM-3 targeting monoclonal and bispecific antibodies in monotherapy and combination therapy and highlighted the emerging role of cell-based therapies.
Outcome prediction by interim positron emission tomography and IgM monoclonal gammopathy in diffuse large B-cell lymphoma
Authors: Johansson Patricia , Alig Stefan , Richter Julia , Hanoun Christine , Rekowski Jan , Dürig Jan , Ylstra Bauke , de Jong Daphne , Klapper Wolfram , Alizadeh Ash A. , Dührsen Ulrich , Hüttmann Andreas 
Published: August 2023

AbstractIn diffuse large B-cell lymphoma (DLBCL), a positive interim positron emission tomography (PET) scan predicts treatment failure, but the proportion of high-risk patients thus identified is small. To improve prediction, we combined the interim PET result with the presence or absence of an associated IgM gammopathy. Of 108 DLBCL patients participating in a prospective trial, nine (8%) were interim PET positive and 19 (18%) had an IgM gammopathy. The monoclonal protein was not associated with distinguishing genetic features, and its light chain restriction was not always concordant with the light chain restriction of the lymphoma. The information provided by interim PET and IgM gammopathy was combined to dichotomize the population into sizeable high-risk (1–2 adverse factors) and low-risk groups (no adverse factor) with widely different outcomes (population size, 25% vs. 75%; 3-year risk of progression, 51% vs. 10%; 3-year overall survival, 64% vs. 95%). Multivariable analyses including established risk factors revealed the interim PET result and the IgM gammopathy status to be the only factors significantly associated with outcome. Information about interim PET response and IgM gammopathy may be useful in studies testing risk-adapted treatment strategies.
Multi-disciplinary community-based group intervention for fibromyalgia: a pilot randomized controlled trial
Authors: Turcotte Kara , Oelke Nelly D. , Whitaker Gina , Holtzman Susan , O’Connor Brian , Pearson Neil , Teo Michelle 
Published: August 2023

AbstractFibromyalgia is characterized by widespread pain, fatigue, sleep disturbances, mood disturbances, and cognitive impairment. Most individuals with fibromyalgia experience poorly managed symptoms and increased healthcare service use. Multicomponent therapies, with a focus on nonpharmacological modalities, are increasingly supported in the literature. However, given the limited resources available, implementation in smaller communities remains a challenge. This research tested a community-based multidisciplinary group intervention for individuals diagnosed with FM living in a small urban centre. The primary outcome was perceptions of quality of care and secondary outcomes included disease-related functioning, anxious and depressive symptoms, pain beliefs, and health service utilization. A pilot randomized control trial was conducted in which 60 patients diagnosed with fibromyalgia were randomized into a 10-week community-based multidisciplinary group intervention program or usual care. Treatment components included twice-weekly exercise sessions and weekly education sessions (e.g., pain education, cognitive behavioral strategies for stress, nutrition, peer support). The trial (NCT03270449) was registered September 1 2017. Statistically significant post-intervention improvements were found in the primary outcome, perceived quality of care (Cohen’s d = 0.61, 0.66 for follow up care and goal setting, respectively). Secondary outcomes showing statistically significant improvements were disease-related daily functioning (Cohen’s d = 0.70), depressive symptoms (Cohen’s d = 0.87), and pain beliefs (Cohen’s d = 0.61, 0.67, 0.82 for harm, disability and control, respectively). No adverse events were reported. Community-based multidisciplinary group interventions for fibromyalgia show promise for improving satisfaction with quality of care, disease-related functioning, and depression, and fostering more adaptive pain beliefs.
Can vitamin D be an adjuvant therapy for juvenile rheumatic diseases?
Authors: Stawicki Maciej K. , Abramowicz Paweł , Sokolowska Gabriela , Wołejszo Sebastian , Grant William B. , Konstantynowicz Jerzy 
Published: August 2023

AbstractVitamin D, known for its essential role in calcium and bone homeostasis, has multiple effects beyond the skeleton, including regulation of immunity and modulation of autoimmune processes. Several reports have shown suboptimal serum 25 hydroxyvitamin D [25(OH)D] levels in people with different inflammatory and autoimmune rheumatic conditions, and an association between 25(OH)D levels, disease activity and outcomes. Although most available data pertain to adults, insights often are extended to children. Juvenile rheumatic diseases (JRDs) are a significant health problem during growth because of their complex pathogenesis, chronic nature, multisystemic involvement, and long-term consequences. So far, there is no definitive or clear evidence to confirm the preventive or therapeutic effect of vitamin D supplementation in JRDs, because results from randomized controlled trials (RCTs) have produced inconsistent outcomes. This review aims to explore and discuss the potential role of vitamin D in treating selected JRDs. Medline/PubMed, EMBASE, and Scopus were comprehensively searched in June 2023 for any study on vitamin D supplementary role in treating the most common JRDs. We used the following keywords: “vitamin D” combined with the terms “juvenile idiopathic arthritis”, “juvenile systemic scleroderma”, “juvenile systemic lupus erythematosus”, “juvenile inflammatory myopathies”, “Behcet disease”, “periodic fever syndromes” and “juvenile rheumatic diseases”. Observational studies have found that serum 25(OH)D concentrations are lower in juvenile idiopathic arthritis, juvenile systemic lupus erythematosus, juvenile systemic scleroderma, Behcet disease and proinflammatory cytokine concentrations are higher. This suggests that vitamin D supplementation might be beneficial, however, current data are insufficient to confirm definitively the complementary role of vitamin D in the treatment of JRDs. Considering the high prevalence of vitamin D deficiency worldwide, children and adolescents should be encouraged to supplement vitamin D according to current recommendations. More interventional studies, especially well-designed RCTs, assessing the dose–response effect and adjuvant effect in specific diseases, are needed to determine the potential significance of vitamin D in JRDs treatment.
Effects of glutamine on plasma protein and inflammation in postoperative patients with colorectal cancer: a meta-analysis of randomized controlled trials
Authors: Xiong Kai , Li Guangsong , Zhang Yu , Bao Tiantian , Li Ping , Yang Xiangdong , Chen Jiang 
Published: August 2023

Abstract
Objective
To evaluate the effects of glutamine on the plasma protein and inflammatory responses in colorectal cancer (CRC) patients following radical surgery.

Methods
We thoroughly retrieved online databases (EMBASE, MEDLINE, PubMed, and others) and selected the randomized controlled trials (RCTs) with glutamine vs. conventional nutrition or blank treatment up until March 2023. The plasma protein associated markers indicators (consisting of albumin (ALB), prealbumin (PA), nitrogen balance (NB), total protein (TP)), inflammatory indicators (including TNF-α, CRP, infectious complications (ICs)), and matching 95% confidence intervals (CIs) were evaluated utilizing the pooled analysis. Subsequently, meta-regression analysis, contour-enhanced funnel plot, Egger’s test, and sensitivity analysis were carried out.

Results
We discovered 26 RCTs, included an aggregate of 1678 patients, out of which 844 were classified into the glutamine group whereas 834 were classified into the control group. The findings recorded from pooled analysis illustrated that glutamine substantially enhanced the plasma protein markers (ALB [SMD[random-effect] = 0.79, 95% CI: 0.55 to 1.03, I2 = 79.4%], PA [SMD[random-effect] = 0.94, 95% CI: 0.69 to 1.20, I2 = 75.1%], NB [SMD[random-effect] = 1.11, 95% CI: 0.46 to 1.75, I2 = 86.9%). However, the content of TP was subjected to comparison across the 2 groups, and no statistical significance was found (SMD[random-effect] = − 0.02, 95% CI: − 0.60 to 0.57, P = 0.959, I2 = 89.7%). Meanwhile, the inflammatory indicators (including TNF-α [SMD[random-effect] = − 1.86, 95% CI: − 2.21 to − 1.59, I2 = 56.7%], CRP [SMD[random-effect] = − 1.94, 95% CI: − 2.41 to − 1.48, I2 = 79.9%], ICs [RR[fixed-effect] = 0.31, 95% CI: 0.21 to 0.46, I2 = 0.00%]) were decreased significantly followed by the treatment of glutamine.

Conclusions
The current study’s findings illustrated that glutamine was an effective pharmaco-nutrient agent in treating CRC patients following a radical surgical operation.
PROSPERO registration number: CRD42021243327.