bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRI Based Fiber Strain Mapping of the Medial Gastrocnemius Muscle at Submaximal Isometric Contractions at Different Ankle Angles.
Authors: Cunnane Brandon , Sinha Usha , Malis Vadim , Hernandez Ryan , Smitaman Edward , Sinha Shantanu 
Published: February 2023

Abstract
Muscle force production is influenced by muscle fiber and aponeurosis architecture. This prospective cohort study utilizes special MR imaging sequences to examine the structure-function in-vivo in the Medial Gastrocnemius (MG) at three-ankle angles (dorsiflexion, neutral, and plantar flexion) and two sub-maximal levels of maximum voluntary contraction (25% and 50% MVC). The study was performed on 6 young male subjects. Muscle fiber and aponeurosis strain, fiber strain normalized to force, fiber length and pennation angle (at rest and peak contraction) were analyzed for statistical differences between ankle positions and %MVC. A two-way repeated measures ANOVA and post hoc Bonferroni-adjusted tests were conducted for normal data. A related samples test with Friedman’s 2-way ANOVA by ranks with corrections for multiple comparisons was conducted for non-normal data. The dorsiflexed ankle position generated significantly higher force with lower fiber strain than neutral and plantarflexed positions. Sarcomere length extracted from muscle fiber length at each ankle angle was used to track the location on the Force-Length curve and showed the MG operates on the curve’s ascending limb. Muscle force changes predicted from the F-L curve going from dorsi- to plantarflexion was less than that experimentally observed suggesting other determinants of force changes with ankle position.
Accuracy of surgical guide in fully guided dental implant surgery
Authors: Al-Anssari Hussein Bassim , Al-Anee Auday M. , Al-Demirchi Jehan Yawez 
Published: February 2023

AbstractPurpose:The purpose of this study is to assess the precision of the surgical guide in static fully guided dental implant surgery.Materials and methods: This research was done on partly edentulous patients whose situations were straightforward and did not require bone or soft tissue augmentation. Fourteen patients (ranging in age from 25 to 70) received 40 dental implants at the dental implant unit, oral and maxillofacial surgery center, Gazi Alhariri Teaching Hospital, Medical City, Baghdad. Using a surgical guide, the dental implants were guided into the most prosthetically-appropriate location. To evaluate the accuracy of the surgical guide in terms of angular deviation, entry point, and implant depth. The actual post-operative implant position was compared to the designed implant position prior to surgery.Results: The mean for the angular deviation between the designed and post-operation actual implant position was (3.83 ± 2.85) degrees, the depth difference was (1.09 ± 0.81 ) millimeters, and the entry point deviation was (0.91 ± 0.73 ) millimeters.Conclusion: The current study revealed that there was no significant difference between the designed and actual implant position regarding all three variables at a P-value of (0.05). Neither biological nor mechanical complications occurred.
Default Network is Associated with Wise Advising from the 2nd- but not the 3rd- Person Perspective
Authors: Hu Chao S. , Zheng Yanbin , Dong Guang-heng , Glassman Harley , Huang Chenli , Xuan Ran 
Published: February 2023

Abstract
Providing advice to others is an important component of wisdom. We conducted a study to test the hypothesis that the Default Mode Network (DMN) is associated with wisdom when advising from a self-referential perspective. This is due to the involvement of the DMN in reflecting on personal life experiences. Altogether, 52 healthy Chinese adults provided advice on various life dilemmas using a second- or third-person perspective after receiving a resting-state functional MRI scan. The amplitude of low-frequency fluctuation (ALFF) was measured in regions of the DMN and the whole brain during resting states. Moreover, trained raters rated the participants' advice on three wisdom subcomponents (i.e., metacognitive humility (MH), meta-level flexibility, and perspective-taking). The results showed that participants felt a significantly smaller psychological distance from the second- than the third-person perspective when advising protagonists on life dilemmas. Relatedly, the rostral ACC was significantly more associated with MH when advising from the second-person perspective, while the dorsal ACC was more associated with MH from the third-person perspective. The precuneus and calcarine showed significantly greater association with perspective-taking from the second- than the third-person perspective. Therefore, wise advising from distinct perspectives and psychological distances may be differentiated in the brain.
SIRT4 is an independent prognostic factor in bladder cancer and inhibits bladder cancer growth by suppressing autophagy
Authors: Cai Guohao , Wang Huaiwen , Chen Weijia , Liu Shan , Huang Guoyu 
Published: February 2023

Abstract
Background
Nucleosome-localized sirtuin 4 (SIRT4) was found to function as an oncogene and tumor suppressor genes in different tumors, respectively. However, the clinical significance of SIRT4 in bladder urothelial carcinoma (BLCA) has not been assessed, as well as the analysis of the function of SIRT4 in BLCA.
Methods
In this study, we assessed the levels of SIRT4 protein in BLCA tissues and its association with clinicopathological parameters and overall survival time of BLCA patients by immunohistochemical staining of tissue microarrays containing 59 BLCA patients. Then, we constructed BLCA cell lines (T24) with overexpression or interference SIRT4 by lentiviral infection. The effects of SIRT4 on the proliferation, migration and invasive ability and of T24 cells were investigated using cell counting kit-8 (CCK-8) assays, wound healing assays, migration and invasion assays. Moreover, we also investigated the effect of SIRT4 on cell cycle and apoptosis of T24 cells. Mechanistically, we explored the relationship between SIRT4 and autophagy and its role in the inhibition of BLCA.
Results
We found by immunohistochemistry that SIRT4 protein levels were reduced in BLCA and that lower SIRT4 levels were associated with larger tumor volumes, later T-staging and later AJCC staging in BLCA patients and were an independent prognostic factor in BLCA patients. Overexpression with SIRT4 significantly inhibited the proliferative viability, scratch healing capacity, migratory capacity, and invasive capacity of T24 cells while interfering of SIRT4 had the opposite effect. Moreover, overexpression with SIRT4 significantly inhibited cell cycle and increased the apoptosis rate of T24 cells. Mechanistically, SIRT4 inhibits BLCA growth by suppressing autophagic flow.
Conclusions
Our study suggests that SIRT4 is an independent prognostic factor for BLCA, and that SIRT4 function as tumor suppressor role in BLCA. This suggests a potential target for SIRT4 in the diagnosis and treatment of BLCA.
Association of Angiotensin-I-Converting Enzyme (ACE) Insertion/ Deletion Gene Polymorphism with Preeclampsia Susceptibility in Egyptian women
Authors: Azab Eman Fawzy El , El-kader Rabab Gad , Ali Sameh A. Mohammed , Shaaban Esraa Ibrahim A. , El-Eshmawy Mohamed A. , Hamid Dina Abdel , El-Beltagy Nanis S. , Salem Eman T. , Elsaid Afaf M. , Anber Nahla 
Published: February 2023

Abstract
The current study was designed to investigate the association of angiotensin-I-converting enzyme (I / D) gene polymorphisms with the susceptibility and clinical pattern of preeclampsia among Egyptian cases from the Nile Delta region. Oxidative stress biomarkers, including Serum levels of malondialdehyde, glutathione-s-transferase, superoxide dismutase, nitric oxide, glutathione peroxidase, endothelin-1, and interleukin-6 as a pro-inflammatory biomarker, were assessed by Elisa. In this study, genotyping, and allelic frequencies of the ACE I/D (rs4646994) variant with preeclampsia susceptibility was about 38.2%. In addition, the results revealed that the ACE/ID (rs4646994) genotype distribution was associated with preeclampsia in the studied population from the Nile Delta region of Egypt. Frequencies of the D allele and DD genotype were significantly increased, while frequencies of the I allele and ID genotype were significantly decreased in the preeclampsia patients when compared with the control subjects (P = 0.014, OR = 1.94, 95% CI = 1.254–3.233 for DD) and (P = 0.016, OR = 1.4, 95% CI = 1.061-2.10 for D). Our findings suggest the association between rs4646994 and susceptibility to preeclampsia in Egyptian cases from the Nile Delta region. Examining the impact of ACE gene variants on preeclampsia may be a valuable method for locating and treating women at risk. Moreover, the angiotensin-I-converting enzyme DD genotype and D allele were associated with preeclampsia as risk factors for Egyptian women. There was a significant association between the serum levels of oxidative stress biomarkers and pro-inflammatory biomarker of preeclampsia compared to the healthy group, with P < 0.05.
Experimental Study on Light Weight Concrete using Plastic Waste as a Partial Replacement of Fine Aggregate
Authors: Mozumder R. S. , Abedin M. M. , Islam M. T. 
Published: February 2023

Abstract
Waste from plastic materials is outstripped due to the growth of industrialization and urbanization. Plastic materials are non-biodegradable; decomposition is not possible all the time. Recycled plastic materials by using concrete, will be a great deal for plastic management for a certain period. Aims to measure the optimum percentage of plastic in concrete without a reduction in concrete strength. The goal of this experimental investigation is to clarify the shear cracking behavior of reinforced concrete beams with the combination of fine aggregates such as Recycled Polyethylene Terephthalate (RPET) and Polypropylene (PP) in the weight fraction of fine aggregate. Using the provision of Mix Design ACI 211.1-91, the M28 concrete grade was created. The mechanical characteristics and shear performance were examined for concrete made utilizing various hybrid combinations. Plastic materials were collected and passed through a No-4 sieve (4.76mm). Reinforced concrete beams(750mm*150mm*150mm) and cylinder specimens of concrete (100mm diameter and 200mm height) were made by the mixture of plastic materials as a percentage of total fine aggregate in the mix (0%, 2%, 4%, 6%, 8%, 10%). The beams were conducted for the shear capacity test and the cylinder specimens for the compressive test and tensile splitting test. The beams are reinforced with two 12 mm steel bars in the tension zone of the beam with a proper clear cover. The experimental findings demonstrate which partial replacement of fine aggregate produced the best outcomes and also analyze shear behavior and fracture development.
Compensating small data with large filters for accurate liver vessel segmentation
Authors: Chen Wen , Zhao Liang , Bian Rongrong , Li Qingzhou , Zhao Xueting , Zhang Ming 
Published: February 2023

Abstract
Background: Segmenting liver vessels on computed tomography images is essential for diagnosing liver diseases, planning surgeries and delivering radiotherapy. Nevertheless, identifying vessels is a challenging task due to the tiny cross-sectional areas occupied by vessels, which has posed great challenges for vessel segmentation, such as limited features to be learned and difficult to construct high-quality as well as large-volume data.
Methods: We present an approach that only requires a few labeled vessels but delivers significantly improved results. Our model starts with vessel enhancement by fading out liver intensity and generates candidate vessels by a classifier fed with a large number of image filters. Afterwards, the initial segmentation is refined using Markov random fields.
Results: In experiments on the well-known dataset 3D-IRCADb, the accuracy is improved to 0.99, and the averaged Dice coefficient is lifted to 0.63. These results are significantly better than those obtained from existing machine-learning approaches and comparable to those generated from deep-learning models.
Conclusion: Sophisticated integration of large number filters is able to pinpoint effective features from liver images that are sufficient to distinguish vessels from other liver tissues under a scarcity of large-volume labeled data. The study can shed light on medical image segmentation, especially for those without sufficient data.
Development of Silica-Collagen Composite as Corneal Substitute through Sol-Gel Additive Manufacturing
Authors: Mandal Dibyendu , Chattopadhyay Himadri , Halder Kumaresh 
Published: February 2023

Abstract
The inherent properties of the healthy cornea, namely its strength, transparency and precise curvature enable it to withstand external injury and provides resistant to intraocular pressure, also allowing 95% transmission of incoming lightand providing 70% of the focusing power of the eye. Corneal transparency is dependent on the specific arrangement of collagen within the stroma. The research thrives for synthesis of a composite comprised of Collagen, the basic protein that can be abundantly found in human body and silica which is biosafe and biocompatible to physiological system and can act as a scaffold for tissue engineering and drug delivery. The starting materials of the synthesis are diluted Silica precursor and two types of collagen-I and III. Collagen type III is predominantly found on the epithelium and endothelium of the cornea which can enhance the mechanical property and optical property of the hybrid. Sol Gel technique has been applied for the synthesis of the composite and finally lyophilized after the pH has been stabilized around 7.2-7.4 to obtain dehydrated silica collagen composite. Optical property of the developed composite closely mimics the collagen hybrids from earlier work in this field. The composite exhibits crystallinity due to the presence of silica as it evidenced from its XRD plot. Other material characterizations, viz. FTIR and SEM have been performed on the sample to identify the microstructural nature of the composite.
Study on Central Tearing Properties of Kapton Membrane
Authors: Liu Yan , Wang Zechen , Fan Lei , Chen Yixian 
Published: February 2023

Abstract
In order to master the tearing properties of Kapton membrane, the main material of the inflatable antenna reflector, research on the tearing property of Kapton membrane has been carried out based on experiment, theoretical analysis and numerical simulation. The effects of the slit angle and the temperature on the tearing properties of the membrane were respectively considered in two groups of central tearing tests, and the whole slit propagation and failure forms of the membrane were analyzed. According to the test results, it is found that four theories were used to predict its tearing strength under different slit angles, and based on goodness of fit, Thiele empirical formula can better predict the tearing strength of Kapton membrane. XFEM (Extended finite element method) was used to simulate the slit expansion of membrane materials. The results showed that the simulation method could not only well reflect the whole slit propagation of membrane, but also accurately obtain the tearing strength of membrane materials. This paper is the first time to accumulate data for the tearing properties of Kapton menbrane. The conclusions and research methods can provide references for the inflatable structure design and structural safety evaluation of Kapton membrane in engineering applications.
Effects of Ethyl Gallate and Propyl Gallate on Dextran Sulfate Sodium (DSS)-Induced Ulcerative Colitis in C57BL/6J Mice: Preventive and Protective
Authors: Chougule Priyanka Raju , sangaraju rajendra , patil pradeep B , Qadri SSYH , panpatil virendra , bhanoori manjula , Sinha Sukesh Narayan 
Published: February 2023

Abstract
Objective and design: Inflammatory bowel disease (IBD) is an idiopathic inflammatory condition of the digestive system marked by oxidative stress, leukocyte infiltration, and elevation of inflammatory mediators. In this study, we demonstrate the protective effect of Ethyl gallate (EG), a phytochemical, and Propyl gallate (PG), an antioxidant, given through normal drinking water (DW) and copper water (CW) in various combinations, which had a positive effect on the amelioration of DSS-induced ulcerative colitis in C57BL/6J mice.
Materials and methods: We successfully determined the levels of proinflammatory cytokines and Antioxidant enzymes by ELISA, tracked Oxidative/Nitrosative stress (RO/NS) by in vivo imaging (IVIS) using L-012 chemiluminescent probe, disease activity index (DAI), histopathological and morphometric analysis of colon in DSS-induced Colitis in a model.
Results: The results revealed that oral administration of Ethyl gallate and Propyl gallate at a dose of 50 mg/kg considerably reduced the severity of colitis and improved both macroscopic and microscopic clinical symptoms. The limits of proinflammatory cytokines (TNF-α, IL-6, IL-1β and IFN-γ) in colonic tissue were considerably reduced in the DSS+EG-treated and DSS+PG-treated groups, compared to the DSS alone treated group. IVIS imaging of animals from the DSS+EG and DSS+PG treated groups showed a highly significant decrease in RO/NS species relative to the DSS control group, with the exception of the DSS+PG/CW and DSS+EG+PG/CW treated groups. We also observed lower levels of myeloperoxidase (MPO), nitric oxide (NO), and lipid peroxidation (LPO) and higher levels of GST and superoxide dismutase (SOD). In addition, we showed that the EG, PG, and EG+PG-treated groups had a healing impact on DAI score, body weight, and colon length in mice with DSS-induced colitis. In this 21-day study, mice were treated daily with test substances and were challenged to DSS from day 7 to 14.
Conclusion: Our study highlights the protective effect of ethyl gallate and propyl gallate in various combinations which, in pre-clinical animals, serves as an anti-inflammatory drug against the severe form of colitis, indicating its potential for the treatment of IBD in humans. In addition, propyl gallate was investigated for the first time in this study for its anti-colitogenic effect with normal drinking water and reduced effect with copper water.
A half-discrete Hilbert-type inequality in the whole plane with the constant factor related to cotangent function
Authors: You Minghui 
Published: February 2023

Abstract
In this work, by the introduction of some parameters, a new half-discrete kernel function in the whole plane is defined, which involves both the homogeneous and the non-homogeneous cases. By employing some techniques of real analysis, especially the way of weight function, a new half-discrete Hilbert-type inequality with the new kernel function, as well as its equivalent Hardy-type inequalities are established. Moreover, it is proved that the constant factors of the newly obtained inequalities are the best possible. Lastly, assigning special values to the parameters, some new half-discrete Hilbert-type inequalities with special kernels are presented at the end of the paper.
2020 Mathematics Subject Classification: Primary 26D15, 26D10; Secondary 47B38.
Sinonasal Renal Cell Like Adenocarcinoma; A Report of Rare Entity with Emphasis on its Association with Von Hippel Lindau Syndrome
Authors: AlMadan Nasser , AlMohammed Abdulrahman , Bardisi Mahmoud , AlGhamdi Doaa 
Published: February 2023

Abstract
Background
Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare entity that was introduced to head and neck tumors classification on 2017 as an emerging entity. Clinically, it could be asymptomatic or show non-specific symptoms like epistaxis, nasal obstruction, or hyposmia. Diagnosis of the lesion is challenging, especially in small biopsies, and requires utilization of clinical, radiological, histopathological and ancillary tests for accurate characterization of the lesion. There is around 20 cases reported in the literature with 3 cases associated with VHL syndrome.
Case Presentation
A 41 years old female with a nasal mass for two years ago that presented initially as frequent epistaxis from the right side. Histopathological examination revealed proliferation of clear cells associated with hemorrhagic background forming follicular and glandular structure and dense eosinophilic secretion. Tumor cells were diffusely positive for CK7, EMA, and Inhibin while were negative for CK20, P63, CK 5/6, CD10, RCC, TTF1, PAX8, CEA, and GATA3. Proliferation index (KI67) was less than 5% (Figure.3). The diagnosis was consistent with sinonasal renal cell-like adenocarcinoma. The patient has no recurrence and no symptoms after 1 year.
Conclusion:
Our study report a rare case of SNRCLA with discussion of the histological features and its association with VHL syndrome.
Periodontitis and non-alcoholic fatty liver disease: a Mendelian randomisation analysis
Authors: Yu Feiyan , Wu Dongchao , Han Chong , Wang Qianqian , Yang Yang , Li Yi , Qin Rao , Xu Linkun , Chen Yue , He Dongning 
Published: February 2023

Abstract
Background
Previous observational and epidemiological studies have reported the association between periodontitis (PD) and non-alcoholic fatty liver disease (NAFLD). However, evidence from long-term randomized controlled trials (RCTs) is lacking. Therefore, this study aimed to explore the causal relationship between PD and NAFLD.
Methods
Genetic information for individuals of European ancestry with PD (17,353 clinically diagnosed cases and 28,210 controls) and NAFLD (8,434 clinically diagnosed cases and 770,180 controls) were obtained using published genome-wide association study statistics, following which we conducted two-sample bivariate Mendelian randomisation (MR) analyses. Various techniques such as inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods were used to calculate the causal relationship between exposure and the result.
Results
No causal effect of genetically determined PD on NAFLD existed (odds ratio [OR] = 0.99, 95% confidence interval [CI]: 0.90–1.10, P = 0.95). Furthermore, no causal effect of NAFLD on PD was observed in the reverse MR analysis (OR = 1.02, 95% CI: 0.92–1.13, P = 0.63). No heterogeneity was observed between individual single nucleotide polymorphisms pursuant to the heterogeneity assessment (Q > 0.1). Horizontal pleiotropy pursuant to the outcomes of MR-Egger regression and MR Pleiotropy RESidual Sum and Outlier overall tests (P > 0.1) were less likely to distort the causal relationship between PD and NAFLD.
Conclusion
Collectively, we did not find substantial evidence to support a causal association between PD and NAFLD in this bidirectional MR study.
Clinical relevance:
Periodontitis does not seem to be a risk factor for worsening of non-alcoholic fatty liver disease.