bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Management of Hydrocephalus in Midline Posterior Fossa Cystic Collections: Surgical Outcome From a Retrospective Single-Center Case Series of 54 Consecutive Pediatric Patients
Authors: Guida Lelio , Benichi Sandro , Bourgeois Marie , Paternoster Giovanna , James Syril , De Saint Denis Timothée , Dangouloff Ros Volodia , Beccaria Kevin , Blauwblomme Thomas 
Published: March 2023

BACKGROUND:
Hydrocephalus frequently occurs with midline posterior fossa cystic collections. The classification of this heterogeneous group of developmental anomalies, including Dandy–Walker malformation, persisting Blake's pouch, retrocerebellar arachnoid cysts, and mega cisterna magna, is subject of debate. The absence of diagnostic criteria is confusing regarding the ideal management of PFCC-related hydrocephalus.

OBJECTIVE:
To decipher the surgical strategy for the treatment of children with PFCC-related hydrocephalus through a retrospective analysis of the surgical outcome driven by their clinical and radiological presentation.

METHODS:
This study enrolled patients operated of symptomatic PFCC-related hydrocephalus. Clinical and MRI features were examined, as well as the surgical outcome. Unbiased subgroup classification of the patients was performed with multiple component analysis as a function of imaging characteristics and hierarchical clustering on principal component. Outcome was assessed with binomial logistic regression and Kaplan–Meier analysis.

RESULTS:
Fifty-four patients were included between 2007 and 2021. Multiple component analysis suggested that cerebellar and vermian hypoplasia, vermian rotation, basal–tentorial angle, and fastigial angle were strongly correlated. Hierarchical clustering and the distribution of the patients in the bidimensional plot showed the clear segregation of 3 major clusters, which correlated with the radiological diagnosis (P < .01). Binomial logistic regression and survival analysis showed that endoscopic third ventriculostomy was an effective treatment for patients with persisting Blake's pouch, while failing to control hydrocephalus in most of patients with Dandy–Walker malformation.

CONCLUSION:
Preoperative MRI in patients with PFCC-related hydrocephalus is essential to better define the diagnosis. The choice of treatment strategy notably relies on correct radiological diagnosis.
Novel Postoperative Serum Biomarkers in Atypical Meningiomas: A Multicenter Study
Authors: Chang Won Ick , Byun Hwa Kyung , Lee Joo Ho , Park Chul-Kee , Kim In Ah , Kim Chae-Yong , Chang Jong Hee , Kang Seok-Gu , Lee Sang Hyung , Kuranari Yuki , Tamura Ryota , Toda Masahiro , Wee Chan Woo , Yoon Hong In 
Published: March 2023

BACKGROUND:
There has been no known serum biomarker to predict the prognosis of atypical meningioma.

OBJECTIVE:
To investigate the prognostic impact of serum biomarkers in patients newly diagnosed with resected intracranial atypical meningiomas.

METHODS:
This study enrolled 523 patients with atypical meningioma who underwent surgical resection between 1998 and 2018 from 5 Asian institutions. Serum laboratory data within 1 week after surgery were obtained for analysis. Optimal cutoffs were calculated for each serum marker using the maxstat package of R.

RESULTS:
Of 523 patients, 19.5% underwent subtotal resection and 29.8% were treated with adjuvant radiation therapy (ART). Among the 523 patients, 454 were included in the multivariate analysis for the progression/recurrence (P/R) rate excluding patients with incomplete histopathologic or laboratory data. On multivariate analysis, tumor size >5 cm, subtotal resection, and postoperative aspartate aminotransferase/alanine transaminase (De Ritis) ratio >2 were associated with higher P/R rates, whereas ART and postoperative platelet count >137 × 103/μL were associated with lower P/R rates. In the subgroup of patients treated with ART, tumor size >5 cm and postoperative neutrophil-to-lymphocyte ratio >21 were associated with higher P/R rates. By contrast, postoperative De Ritis ratio >2 remained an adverse prognosticator in patients not treated with ART.

CONCLUSION:
Postoperative De Ritis ratio, platelet count, and neutrophil-to-lymphocyte ratio were revealed as a novel serum prognosticator in newly diagnosed atypical meningiomas. Additional studies are warranted to validate its clinical significance and biological background.
Diverse branching forms regulated by a core auxin transport mechanism in plants
Authors: Spencer Victoria M. R. , Bentall Lucy , Harrison C. Jill 
Published: March 2023

ABSTRACT
Diverse branching forms have evolved multiple times across the tree of life to facilitate resource acquisition and exchange with the environment. In the vascular plant group, the ancestral pattern of branching involves dichotomy of a parent shoot apex to form two new daughter apices. The molecular basis of axillary branching in Arabidopsis is well understood, but few regulators of dichotomous branching are known. Through analyses of dichotomous branching in the lycophyte, Selaginella kraussiana, we identify PIN-mediated auxin transport as an ancestral branch regulator of vascular plants. We show that short-range auxin transport out of the apices promotes dichotomy and that branch dominance is globally coordinated by long-range auxin transport. Uniquely in Selaginella, angle meristems initiate at each dichotomy, and these can develop into rhizophores or branching angle shoots. We show that long-range auxin transport and a transitory drop in PIN expression are involved in angle shoot development. We conclude that PIN-mediated auxin transport is an ancestral mechanism for vascular plant branching that was independently recruited into Selaginella angle shoot development and seed plant axillary branching during evolution.
Novel Strategy for the Management of Cervical Multicystic Diseases
Authors: Yoshino Ai , Kobayashi Eiji , Tsuboyama Takahiro , Fukui Hideyuki , Tomiyama Noriyuki , Sato Kazuaki , Morii Eiichi , Nakatani Eiji , Komura Naoko , Sawada Ikuko , Tanaka Yusuke , Hori Kensuke , Yoshimura Akihiko , Takahashi Ryoko , Iwamiya Tadashi , Hisa Tsuyoshi , Nishimura Sadako , Kitai Toshihiro , Yokota Hiromi , Shindo Mariko , Miyata Hiromi , Hashimoto Namiko , Sakiyama Kanako , Abe Hazuki , Ueda Yutaka , Kimura Tadashi 
Published: March 2023

Abstract
Purpose
To investigate the clinical practices of diagnosing multicystic cervical lesions as a means to develop a more appropriate diagnostic algorithm for gastric-type adenocarcinoma (GAS) and its precursors.

Methods
Clinical information for 159 surgically treated patients for multicystic disease of the uterine cervix was collected from 15 hospitals. We performed a central review of the MRI and pathological findings. The MRI findings were categorized into four types including two newly proposed imaging features based on the morphology and distribution of cysts, and the diagnosis accuracy was assessed. Among the four MRI types, types 1 and 2 were categorized as benign lesions that included LEGH; type 3 were precancerous lesions (with an assumption of atypical LEGH); and type 4 were malignant lesions.

Results
The central pathological review identified 56 cases of LEGH, seven with GAS, four with another form of carcinoma, and 92 with benign disease. In clinical practice, over-diagnosis of malignancy (suspicion of MDA) occurred for 12/19 cases (63.2%) and under-diagnosis of malignancy occurred for 4/11 (36%). Among the 118 patients who had a preoperative MRI and underwent a hysterectomy, type 3 or 4 MRI findings in conjunction with abnormal cytology were positively indicative of premalignancy or malignancy, with a sensitivity and specificity of 61.1% and 96.7%, respectively.

Conclusions
Although the correct preoperative diagnosis of cervical cancer with a multicystic lesion is challenging, the combination of cytology and MRI findings creates a more appropriate diagnostic algorithm that significantly improves the diagnostic accuracy for differentiating benign disease from premalignancy and malignancy.
The experiences of siblings of children with chronic illness of health-related communication directed at them: a systematic review protocol and thematic synthesis of qualitative studies
Authors: Coveney Kate , O'Donnell Deirdre , Stokes Diarmuid , Kroll Thilo 
Published: March 2023

The psychological, social and financial impact that chronic illness can have on a family and in particular the siblings of children with chronic illness (SCWCI) is well documented. Siblings are at risk of a variety of psychosocial and physical problems such as suffering from anxiety, experiencing headaches, appetite loss. However, the experiences with health-related communication of SCWCI is not well known. This may leave them with suboptimal information. The aim of this systematic review described in this protocol is to understand SCWCI experience of targeted health-related communication; detailing the communication strategies utilised, how helpful the information was and what they wish would be different. The Preferred Reporting Items for Systematic reviews and Meta-analysis for Protocols (PRISMA-P) checklist will be used to frame this protocol. Registration: PROSPERO (393998, 03 February 2023).
Phenotypic resistance to pyrethroid associated to metabolic mechanism in Vgsc-L995F-resistant Anopheles gambiae malaria mosquitoes
Authors: Kouadio France-Paraudie A. , Sika Angèle N. , Fodjo Behi K. , Sadia Christabelle G. , Oyou Sébastien K. , Ouattara Allassane F. , Mouhamadou Chouaïbou S. 
Published: March 2023

Background: The indiscriminate use of insecticides in agriculture and public health lead to a selection of resistance mechanisms in malaria vectors compromising vector control tools and strategies. This study investigated the metabolic response in the Vgsc-L995F Anopheles gambiae Tiassalé resistance strain after long-term exposure of larvae and adults to deltamethrin insecticide. Methods: We exposed, over 20 generations, Vgsc-L995F An. gambiae Tiassalé strain larvae to deltamethrin (LS) and adults to PermaNet 2.0 (AS) and combining exposure at larvae and adult stages (LAS) and compared to unexposed (NS) group. All four groups were subjected to the standard World Health Organization (WHO) susceptibility tube tests using deltamethrin (0.05%), bendiocarb (0.1%) and malathion (5%). Vgsc-L995F/S knockdown-resistance (kdr) mutation frequency was screened using multiplex assays based on Taqman real-time polymerase chain reaction (PCR) method. Additionally, expression levels of detoxification enzymes associated to pyrethroid resistance, including CYP4G16, CYP6M2, CYP6P1, CYP6P3, CYP6P4, CYP6Z1 and CYP9K1, and glutathione S-transferase GSTe2 were measured. Results: Our results indicated that deltamethrin resistance was a response to insecticide selection pressure in LS, AS and LAS groups, while susceptibility was observed in NS group. The vectors showed varied mortality rates with bendiocarb and full susceptibility to malathion throughout the selection with LS, AS and LAS groups. Vgsc-L995F mutation stayed at high allelic frequency level in all groups with a frequency between 87% and 100%. Among the overexpressed genes, CYP6P4 gene was the most overexpressed in LS, AS and LAS groups. Conclusion: Long-term exposure of larvae and adults of Vgsc-L995F resistant-An. gambiae Tiassalé strain to deltamethrin and PermaNet 2.0 net induced resistance to deltamethrin under a significant effect of cytochromes P450 detoxification enzymes. These outcomes highlight the necessity of investigating metabolic resistance mechanisms in the target population and not solely kdr resistance mechanisms prior the implementation of vector control strategies for a better impact.
The Other Invisible Hand: How Markets—as Institutions—Propagate Conformity and Valuation Errors
Authors: Levine Sheen S. , Zajac Edward J. 
Published: March 2023

The institutionalized status of markets is undoubtedly due to their presumed ability to aggregate individual bids into a single unbiased estimate of value. While not denying this emergent property of market processes, we propose and test an alternative perspective that explains how market processes can also generate the propagation of individual valuation errors that aggregate into price bubbles. Theoretically, we advance a microinstitutional perspective that draws from social and evolutionary psychology linking market processes to a more general process of institutionalization, whereby individuals seeking the adaptive benefits of conformity may—due to bounded and socially biased rationality—instead generate maladaptive individual and collective outcomes. Empirically, we craft an efficient experimental market and find three sets of evidence consistent with our microinstitutionalization perspective. We first show—at the individual level—that market participants exhibit a social bias toward conformity with the market’s collective valuation, even when the emergent market valuation is demonstrably incorrect. We then show—at the market level—that the range of valuations over time also decreases in a conforming direction, again independent of valuation accuracy. Last, we provide the first experimental test of the long-assumed effect of social ambiguity on institutionalization, finding that market participants’ over-attention to the collective valuation is indeed sensitive to variation in social ambiguity. We conclude by highlighting the relevance of our theoretical perspective, method, and findings for future research on institutions and institutionalization processes, as well as future studies on social influence and conformity-based errors.Funding: S. S. Levine acknowledges research grants from Singapore Management University; the University of Texas at Dallas; and the European Research Council (agreement 695256).Supplemental Material: The online appendix is available at https://doi.org/10.1287/stsc.2022.0173 .
Understanding patient experience of distal tibia or ankle fracture: a qualitative systematic review
Authors: Pearson Nathan A. , Tutton Elizabeth , Gwilym Stephen E. , Joeris Alexander , Grant Richard , Keene David J. , Haywood Kirstie L. 
Published: March 2023

AimsTo systematically review qualitative studies of patients with distal tibia or ankle fracture, and explore their experience of injury and recovery.MethodsWe undertook a systematic review of qualitative studies. Five databases were searched from inception to 1 February 2022. All titles and abstracts were screened, and a subset were independently assessed. Methodological quality was appraised using the Critical Appraisal Skills Programme (CASP) checklist. The GRADE-CERQual checklist was used to assign confidence ratings. Thematic synthesis was used to analyze data with the identification of codes which were drawn together to form subthemes and then themes.ResultsFrom 2,682 records, 15 studies were reviewed in full and four included in the review. A total of 72 patients were included across the four studies (47 female; mean age 50 years (17 to 80)). Methodological quality was high for all studies, and the GRADE-CERQual checklist provided confidence that the findings were an adequate representation of patient experience of distal tibia or ankle fracture. A central concept of ‘being the same but different’ conveyed the substantial disruption to patients’ self-identity caused by their injury. Patient experience of ‘being the same but different’ was expressed through three interrelated themes, with seven subthemes: i) being proactive where persistence, doing things differently and keeping busy prevailed; ii) living with change including symptoms, and living differently due to challenges at work and leisure; and iii) striving for normality, adapting while lacking in confidence, and feeling fearful and concerned about the future.ConclusionAnkle injuries were disruptive, draining, and impacted on patients’ wellbeing. Substantial short- and longer-term challenges were experienced during recovery. Rehabilitation and psychosocial treatment strategies may help to ameliorate these challenges. Patients may benefit from clinicians being cognisant of patient experience when assessing, treating, and discussing expectations and outcomes with patients.Cite this article: Bone Jt Open 2023;4(3):188–197.
Magnitude of External Phosphorus Loading Likely Reduces Effectiveness of Aluminum Sulfate Treatments for Management of Sediment Phosphorus Flux
Authors: Lasater Abbie L. , Haggard Brian E. , Lee Jung Ae 
Published: March 2023

Highlights

Phosphorus fluxes were quantified before and after alum treatments five times between 2014 and 2019.

Phosphorus fluxes were not significantly different from baseline after five treatments spread over six years.

Long-term effectiveness of alum treatments was reduced due to large external phosphorus loads.

Abstract. This study quantified sediment P fluxes under aerobic and anaerobic conditions at Quarry Island Cove at Lake Wister, Oklahoma, before and after alum treatments, which occurred five times between 2014 and 2019. Sediment-water cores were collected from the cove and incubated for 10 days at room temperature under aerobic and anaerobic conditions, and P fluxes were estimated as the slope of the increase in P mass over time divided by the area of the core. Aerobic P fluxes were not significantly different before or after alum treatments. Under anaerobic conditions, P fluxes significantly decreased one week after alum treatments compared to a week before treatment. However, after five treatments across six years, sediment P fluxes under anaerobic conditions were not significantly different than prior to any alum treatments in 2010 and 2014 (3 to 4 mg m-2 day-1). The lack of overall improvement in anaerobic P fluxes over time is likely due to the magnitude of P and sediment loads entering Lake Wister from the watershed, where 92% of the total P load to Lake Wister from 2010 to 2020 was from external sources. Therefore, while alum treatments provide short-term reductions in P fluxes, external P sources must be addressed. Keywords: Aluminum sulfate, Lake management, Nutrient loads, Phosphorus.
Identification of Tree Species and Extent of Material Deterioration of Wood Components in the Yangjia Courtyard Ancient Building
Authors: Yang Yan , Li Bin , Liu Yuqing , Zhang Wenqiang , Wang Chuanbo 
Published: March 2023

Abstract
The identification of the tree species and the extent of material deterioration in the wooden components of the walkway of the first courtyard of the ancient Yangjia Courtyard were analyzed in this study using bright-field microscopy, polarized light, fluorescence, and Fourier-transform infrared (FTIR) spectroscopy methods. The results are as follows: (1) samples No. 1 and No. 2, and No. 4, No. 3, and No. 5 taken from the roots of the wooden pillars were identified as lace-bark pine wood (Pinus bungeana), poplar woods (Populus spp.), large-fruited elm wood (Ulmus macrocarpa), and spruce wood (Picea sp.), respectively on the basis of observation of anatomical structural characteristics and analysis of selection principle of “local selection” in ancient buildings. (2) The observation of polarization and fluorescence and the analysis of FTIR spectra showed that the brightness of crystalline cellulose birefringence reduced severely, and analysis of FTIR spectra showed that the absorption peaks representing cellulose and hemicellulose in the lace-bark pine and spruce wooden components disappeared or decreased. However, the polarization and fluorescence and the FTIR spectra of the poplar and elm wooden components showed that the brightness of the crystalline cellulose birefringence and the absorption peaks remained constant, as the controls did. (3) According to the results of the effects of the polarization and fluorescence effects and the FTIR spectra, we concluded that the lace-bark pine and spruce wooden components were severely attacked by brown rot fungi; in contrast, the wooden components of poplar and elm were not attacked by wood decay fungus, but were attacked by insects. These results provide scientific guidance for subsequent preventive conservation such as preservative treatment and insect prevention.
Efficacy of a mixture of Ginkgo biloba, sesame, and turmeric on cognitive function in healthy adults: Study protocol for a randomized, double-blind, placebo-controlled trial
Authors: Nakase Taizen , Tatewaki Yasuko , Matsudaira Izumi , Kobayashi Kouki , Iki Hikari , Asaoka Haruka , Ekayantri Radiztia , Muranaka Michiho , Murata Hiroyuki , Mutoh Tatsushi , Taki Yasuyuki 
Published: March 2023

Background and purpose
Ginkgo biloba extract (GBE) reportedly ameliorates cognitive function in patients with chronic cerebrovascular insufficiency. However, its efficacy in healthy adults is ambiguous. It was reported that concentrations of terpene lactones, active components of GBE that are present in very low concentrations in the brain, were significantly increased following administration of a mixture of GBE, sesame seed, and turmeric (GBE/MST) in mice. This study aims to investigate the effectiveness of GBE/MST on the cognitive function of healthy adults by comparing it with that of GBE alone.

Methods
Altogether, 159 participants providing informed consent will be recruited from a population of healthy adults aged 20–64 years. Normal cognitive function at baseline will be confirmed using the Japanese version of the Montreal Cognitive Assessment battery. Participants will be randomly assigned in a double-blind manner to the GBE/MST, GBE, and placebo groups in a 1:1:1 ratio. The Wechsler Memory Scale, Trail Making Test, and Stroop Color and Word Test will be used to assess the memory and executive functions at baseline and at the endpoint (24 weeks). For biological assessment, resting state functional magnetic resonance imaging (rs-fMRI) will be performed simultaneously with the neuropsychological tests.

Discussion
This study aims to obtain data that can help compare the profile changes in memory and executive functions among participants consuming GBE/MST, GBE alone, and placebo for 24 weeks. Alterations in the default mode network will be evaluated by comparing the rs-fMRI findings between baseline and 24 weeks in the aforementioned groups. Our results may clarify the impact of GBE on cognitive function and the functional mechanism behind altered cognitive function induced by GBE components.

Trial registration
This study was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR; registration number: UMIN000043494). This information can be searched on the website of the International Clinical Trials Registry Platform Search Portal of the World Health Organization under the Japan Primary Registries Network.