bluuebunny/crossref_metadata_2025_split huggingface dataset:
PS-C01-5: RELATIONSHIP BETWEEN MICROANGIOPATHY AND MACROANGIOPATHY IN DIABETIC PATIENTS
Authors: Obeid Hasan , Eveilleau Kornelia , Hallab Magid , Wessels Hester , Nasr Imad Abi , Marre Michel , Segal David 
Published: January 2023

Background:
Diabetes patients are known to produce diabetic retinopathy. Pulse wave velocity (PWV) provides arterial stiffness and hemodynamic parameters. We studied the effect of diabetic retinopathy in different stages on arterial stiffness in diabetics. We measured vascular aging with a new system (pOpmètre) that measures PWV, Ankle-Brachial Index (ABI) and Central Blood pressure

Methods:
83 type 1 diabetes patients attending the clinic (59% male) aged (42 ± 1.54 years). Insulin dependent diabetic patients with retinopathy (N = 61) or without retinopathy (N = 22) with abnormal albuminuria ratio (17%), mean diabetes duration 26 years. All patients underwent vascular assessment with pOpmètre (Axelife - France). The following parameters were measured in each patient, PWV, ABI and central Blood Pressure, non-invasively and without cuff compression.

Results:
PWV correlated with the degree of retinopathy (F = 13.80; p < 10^(-4)) and with aging (r2 = 0.25; p < 10^(-4)), and with diabetes duration (r2 = 0.12; p < 0.002) independently of gender, HbA1c, smoking, BMI, diabetes duration or lipid profile. Aging and diabetes duration were not associated (ANOVA, p = 0.5) to the degree of retinopathy unlike PWV.

Conclusions:
there is a high interdependence between microvascular and macrovascular lesions in this population of well treated type I diabetic patients with or without retinopathy.
PS-C02-9: ASSOCIATIONS OF SHORT-TERM BLOOD PRESSURE VARIABILITY WITH ELECTROCARDIOGRAM PARAMETERS IN OBESITY-RELATED HYPERTENSION
Authors: Luo Xing , Zhang Yu Xiao , Zheng Ting Ting , Luo Di Chao , Tian Gang 
Published: January 2023

Background:
Both blood pressure variability (BPV) and mean blood pressure levels can induce target organ damage and affect the prognosis in patients with hypertension. The fluctuation of BPV is more obvious among patients with obesity-related hypertension, yet few researches have shown the correlation between BPV and electrocardiographic parameters.

Objective:
This study aimed to analyze the association of short-term BPV with electrocardiographic parameters, so as to identify the risk of arrhythmia in patients with obesity-related hypertension.

Methods:
All enrolled 330 subjects from the Department of Cardiovascular Medicine of the First Affiliated Hospital of Xi’an Jiaotong University were diagnosed with obesity-related hypertension. The short-term BPV, including standard deviation(SD), coefficient of variation(CoV), and weighted standard deviation(wSD), were analyzed by ambulatory blood pressure monitoring(ABPM). The atrial parameters(PR interval, maximum duration of P wave(Pmax), and P wave dispersion(Pwd)) and ventricular parameters(QT interval, Tpe interval, and Tpe/QT ratio) were measured on standard 12-lead electrocardiogram. Multivariate ordinary and binary logistic regression were conducted to evaluate the independent association between short-term BPV and electrocardiographic parameters. The study also analyzed the association of renin-angiotensin-aldosterone system (RAAS) with short-term BPV in 129 patients with obesity-related hypertension.

Results:
Although short-term BPV of 24 hours showed little association with electrocardiographic parameters, the association of daytime and nighttime BPV with electrocardiographic parameters was remarkably significant. And reverse dippers also showed longer Pmax than nondippers (P = 0.041). In this study, we found that the incidence of prolonged PR interval increased to 6% in patients with obesity-related hypertension, yet the prevalence was only 1% in healthy population younger than 60 years old. And those with a larger SD of nighttime systolic blood pressure had a longer PR interval(P = 0.025). Furthermore, ordinary logistic regression analysis showed that the nighttime CoV of diastolic blood pressure was independently correlated with PR interval. Meanwhile, logistic regression analysis also showed that the nocturnal blood pressure decline rate was independently associated with Tpe/QT ratio. However, the association of RAAS and short-term BPV was not significant.

Conclusions:
PS-C03-1: FULLY REMOTE INITIATION OF HOME BLOOD PRESSURE MONITORING INCLUDING ELECTRONIC TRANSMISSION OF RESULTS
Authors: Michaud Andre , Cloutier Lyne , Vadeboncoeur Alain , Goupil Remi 
Published: January 2023

Objective:
The pressure exerted on the health care system from COVID-19 pandemic is unprecedented. Social distancing and self-isolation called for innovative, readily implementable, and effective short-term health solutions. The objective of this study was to assess the feasibility of a remote initiation of home health surveillance, including home blood pressure monitoring (HBPM), carried out by confined hypertensive adults diagnosed with COVID-19.

Design and method:
Individuals included in the study were between 40 and 69 years old with a known diagnosis of hypertension and a recent positive SARS-CoV-2 PCR test. During the initial phone contact and following electronic consent, participants were directed to a secure online platform to obtain all the information needed to participate in the study. Each participant received at home the equipment needed for vital signs assessment, including a LifeSource® UA-651BLE BP monitoring device. The Sphygmo® mobile app was used by the participants for the electronic transmission of results. Participants had to assess their symptoms and completed vital signs including two BP measurements, twice a day, for 14 consecutive days. Electronic and written guidance was also provided to participants on the correct method to perform the various vital signs measurements and data collection.

Results:
A total of 46 participants completed the study. The mean age was 54.1 ± 6.9 years and 54% of participants were men. On average, participants performed 12.3 days of measurements, 4.4 BP measurements per day for an average total of 54 BP measurements, Among the 46 participants, 11(24%) sent an email and two participants (4%) made a phone call for technical assistance.

Conclusions:
In a pandemic context, among hypertensive participants with a positive SARS-CoV-2 PCR test, the completed remote initiation of HBPM with electronic transmission of results is feasible. Moreover, participants were able to perform nearly fourteen days of BP measurements including self-assessment of symptoms, twice a day, and transmit their data using a mobile app and a web-based platform.
PS-C03-4: THE REAL WORLD TRENDS IN BLOOD PRESSURE OF DIALYSIS PATIENTS IN JAPAN USING THE WEB-BASED DATABASE
Authors: Sakuma Hirofumi , Matsuki Motoki , Hasebe Naoyuki , Nakagawa Naoki 
Published: January 2023

Objective:
Hypertension is common in dialysis patients, which is frequent as well as poorly controlled. Blood pressure (BP) has a J curve relationship with cardiovascular disease and survival in dialysis patients; however, optimal BP is not well defined. We wanted to learn about the clinical characteristics of Japanese patients undergoing dialysis and the prevalence of cardiovascular death based on systolic blood pressure (SBP) using the Web based Analysis of Dialysis Data Archives (WADDA) system database.

Design and Methods:
We enrolled the patients undergoing dialysis who were recorded pre dialysis SBP from 2012 to 2020 using WADDA system 2.1. According to the Japanese Society of Hypertension guidelines 2019 (JSH 2019), we classified SBP and evaluated their trends over time by gender and age. Moreover, we evaluated the association between SBP and cardiovascular death.

Results:
Using the 2020 database, we looked at 336,759 Japanese patients undergoing dialysis (222,510 men and 114,249 women). The mean age was 69.4 ± 12.5 years, the mean dialysis history was 7.4 ± 7.7 years, and the mean pre dialysis SBP was 152.3 ± 24.7 mmHg. Among these patients, 72% had hypertension, 56.4% had diabetes, 28.9% had ischemic heart disease, and 25.4% had cerebrovascular disease. From 2012 to 2020, there was no change in the percentage of hypertension in each age group. The rate of grade II and III hypertension was predominantly male in the younger population (the twenties to fifties), but it shifted to females in the older population (over sixties). This gender disparity was more pronounced in the grade III hypertension group. Patients with cerebrovascular death had higher rates of hypertension (60.7 percent [gradeI; 26.2%, gradeII; 17.3%, gradeIII; 17.3%]) than those with heart failure death (32.9 percent [gradeI; 18.3%, gradeII; 8.4%, gradeIII; 6.2%]).

Conclusion:
Using the WADDA system, we summarized recent trends in BP of Japanese dialysis patients. We discovered that the rate of hypertension in patients undergoing dialysis has remained high (around 70%) and has not changed over the last decade. Furthermore, we discovered higher rates of hypertension, particularly in younger males, implying that optimal BP management for these populations may reduce cerebrovascular mortality.
PS-C03-12: FINGER-TO-TOE PULSE WAVE VELOCITY IN RESPONSE TO SITTING POSITION
Authors: Philibert Emy , Paré Mathilde , Côté Nadège , Fortier Catherine , Goupil Rémi , Obeid Hasan , Agharazii Mohsen 
Published: January 2023

Objective:
Aortic stiffness is a non-traditional risk factor for cardiovascular disease and mortality and is associated with increased central pulse pressure. It is generally measured by carotid-femoral pulse wave velocity (PWV) in a supine position. We hypothesized that, in a sitting position, the additional hydrostatic pressure exerted on the vascular wall could represent a vascular stress test. Two alternative methods can now estimate aortic stiffness and can be used conveniently in different positions: 1) brachial pulse wave analysis approach used by Mobil-O-Graph and 2) transit time approach using finger-to-toe PWV by photoplethysmography with the pOpmetre. The aim of the present study is to determine the impact of postural changes on PWV and central blood pressure estimation using these two distinct methods.

Design and method:
Central blood pressure and PWV were assessed in 20 healthy subjects using Mobil-O-Graph (PWV-M) and pOpmetre (PWV-pop) in three positions: supine in bed, supine in reclining chair and sitting. Central systolic blood pressure (SBP) was determined by calibration of brachial systolic and diastolic blood pressures by both methods (SBP-M and SBP-pop). Generalized estimating equations were used for analysis.

Results:
The PWV-M remained relatively constant and generally independent of the position (5.5 ± 1.0, 5.3 ± 1.0 and 5.5 ± 1.0 m/s). While PWV-M and PWV-pop were similar in the supine position (5.5 ± 1.0 vs 5.4 ± 1.3 m/s, P = NS), PWV-pop increased very significantly to 5.9 ± 1.5 m/s in supine in reclining chair position (P = 0.04), and to 9.2 ± 1.7 m/s in sitting position (P < 0.001). Central blood pressure estimation remained similar for SBP-M (110.2 ± 10.3 vs 106.9 ± 10.5 vs 108.8 ± 11.1 mmHg, P = NS) and for SBP-pop (107.7 ± 10.4 vs 110.3 ± 9.6 vs 109.5 ± 9.9 mmHg, P = NS).

Conclusions:
These results suggest that estimated PWV by brachial pulse wave analysis remains robust independent of position. However, the estimated finger-to-toe PWV by pulse transit time increases remarkably with the imposition of hydrostatic pressure on the vascular wall. We conclude that the finger-to-toe PWV may provide the opportunity to evaluated vascular wall property in a dynamic fashion using postural changes as a stress test.
PS-C06-3: QUANTITATIVE CARDIAC AUTONOMIC OUTCOMES OF HYDROTHERAPY DURING CHILDBIRTH
Authors: Ghimouz Rym , Dias Raquel Aparecida , Cardoso Claudia de Faria , Nono Daniel Alessander , Junior Jose Antonio Silva , Acuna Juan , Baltatu Ovidiu Constantin , Campos Luciana Aparecida 
Published: January 2023

Objective:
Most hydrotherapy studies during childbirth report findings related to pain using a widespread set of subjective measures. In this study we evaluated warm shower hydrotherapy s effects during childbirth through ECG biomarkers as quantitative cardiac autonomic outcomes.

Design and Methods:
This was a prospective single blind cohort study. The cardiac autonomic function was assessed using heart rate variability (HRV) measures during a deep breathing test using an HRV scanner system with wireless ECG enabling real-time data analysis and visualization. Labor pain and anxiety were assessed using the Visual Analogue Scale for Pain (VASP) and the Beck Anxiety Inventory (BAI), respectively. A total of 105 pregnant women in the first stage of labor who received warm shower hydrotherapy, intravenous analgesia (scopolamine + sodium dipyrone), or spinal anesthetic (bupivacaine + morphine) were enrolled.

Results:
Parasympathetic modulation reflected through RMSSD (root mean square of successive RR interval differences) was significantly reduced by hydrotherapy and intravenous analgesia (before vs. after mean rank diff. 35.73 and 65.93, respectively, p < 0.05). Overall HRV (SDNN, standard deviation of RR intervals) was significantly decreased only by intravenous analgesia (before vs. after mean rank diff. 65.43, p < 0.001). Mean heart rate was significantly increased by intravenous analgesia, while spinal anesthesia reduced it and hydrotherapy did not alter it (before vs. after mean rank diff. -49.35∗, 70.38∗, -24.20NS, respectively, ∗ p < 0.05, NS not significant).

Conclusions:
This study s findings give quantitative support for the use of warm shower hydrotherapy during labor. This study suggests that warm shower therapy may alter the sympathovagal balance, resulting in a shift towards sympathetic predominance as a result of parasympathetic withdrawal, as well as a better anticipation of higher levels of stress during labor. The dependability of hydrotherapy as a nonpharmacological treatment is linked to the completion of more clinical research demonstrating quantitative evidence via outcome biomarkers to support indications pertaining to stress and birth progress.
PS-C08-8: OUTCOMES FROM BLOOD PRESSURE REDUCTION IN PATIENTS WITH DIFFERENT BASELINE CARDIOVASCULAR RISK: SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED TRIALS
Authors: Manta Eleni , Thomopoulos Costas , Kariori Maria , Konstantinidis Dimitrios , Siafi Eirini , Polyzos Dimitrios , Tatakis Fotis , Drogkaris Sotirios , Filippou Christina , Dimitriadis Kyriakos , Tsioufis Konstantinos 
Published: January 2023

Objective:
Blood pressure (BP) lowering is accompanied by reducing cardiovascular (CV) outcomes and death in hypertensive patients. No data are available for the effect of BP lowering in trials stratified according to baseline CV risk that was assessed according to SCORE-2.

Design and method:
A systematic review was conducted to identify randomized trials in electronic databases (Pubmed and CENTRAL, years: 1966 to 9/2021) for the effect of BP-lowering treatment against placebo or less aggressive BP reduction on 6 fatal or non-fatal CV outcomes and all-cause death. Selected studies reported outcomes in patients without a history of previous CV disease. In each study, we calculated baseline cardiovascular risk using SCORE-2. Risk ratios (RR) were calculated together with their 95% confidence interval (CI) under the random-effects model.

Results:
We included 54 studies (i.e., 12 trials with low-to-moderate CV risk, n = 21,192 patients; 13 trials with high risk, n = 66,886; and 29 trials with very high risk, n = 79,061). For a standard SBP/DBP reduction of 10/5 mmHg, the relative risk of the combined outcome of major CV events (i.e., myocardial infarction, stroke, and heart failure) was decreased by 27% (95% CI, 22–35%) in the category of very high-risk patients, and this reduction was significantly greater (P = 0.02) compared to high-risk trials (0.90 [95% CI, 0.77–1.04]). Moreover, CV death showed a significant reduction in the high-risk group compared to the low-moderate risk group (p = 0.005), as well as in the very high-risk group compared to the low-moderate risk group (p = 0.001). The same pattern was observed for all-cause death in the very high-risk group compared to the high-risk group (p = 0.045).

Conclusions:
The greatest outcome benefit from BP lowering in primary prevention is observed in patients at higher baseline cardiovascular risk as calculated by the SCORE-2.
PS-C08-10: RELATIONSHIP OF PHYSICAL ACTIVITY AND MEDICATION ADHERENCE IN HYPERTENSIVE PATIENTS: BEHAVIORAL CARDIOLOGY UNIT DATA
Authors: Fragoulis Christos , Kontogianni Evangelia , Prentakis Andreas , Polyzos Dimitrios , Kariori Maria , Kalos Theodoros , Mantzouranis Emmanouil , Leontsinis Ioannis , Chrysochoou Christina , Politis Antonios , Tsioufis Konstantinos 
Published: January 2023

Objective:
Few studies have examined the relationship between exercise and adherence to antihypertensive medication, examining all possible factors contributing to blood pressure control. The purpose of our study was to access the possible dependence relationship among hypertensive patients visiting the Behavioral Cardiology Unit in a Tertiary Hospital.

Design and method:
The study population consisted of patients reporting to the Behavioral Cardiology Unit in a Tertiary Hospital during a period of 6 months in 2021. In terms of holistic approach, all patients underwent a thorough clinical in-depth interview, using the Morisky Medication Adherence Scale (MMAS8), the Frail Questionnaire Screening Tool (Frailty Score) and the Patient Health Questionnaire-4 (PHQ-4). All patients also provided full history of exercise (at least 150 minutes of physical activity or 75 minutes of intense activity per week), while completing the Duke Activity Status Index (DASI).

Results:
The population consisted of 42 hypertensive patients, 54.8% of them were females, with a mean age of all patients at 55.8 ± 15.2 years. Body Mass Index was averaging at 27.6 kg/m2. Salt consumption above the daily suggested amount (> 5gr/day) was reported by 60% of patients, binge drinking by 43% of them, while 43% had a history of active smoking. High adherence was reported by 17 patients (46%), medium adherence by 14 (37.8%) and low adherence by 6 (16.2%). Results indicate a relationship between exercise and adherence to medication. More specifically, Chi-Square test showed statistical significance between exercise and medium medication adherence in MMAS8 (MMAS8: 6–7, p = 0.033). Moreover, statistical analysis showed significant relationship between exercise, frailty and PHQ-4 score. Particularly, patients with absence of exercise showed higher level of PHQ-4 score (F = 7.07, p = 0.011).

Conclusions:
Our study highlights the possible dependency relationship of exercise and adherence to medication. Results indicate that patients with good adherence to medication have better behavioral activation. There is need for further research in this domain, to confirm the findings.
PS-C08-11: RELATIONSHIP OF AMBULATORY WAKE SYSTOLIC BLOOD PRESSURE AND COGNITIVE FUNCTIONING IN CHILDREN AND ADOLESCENTS: THE SHIP-AHOY STUDY
Authors: Hooper Stephen , Lande Marc , Flynn Joseph , Samuels Joshua , Meyers Kevin , Ferguson Michael , Urbina Elaine 
Published: January 2023

Objective:
24-Hour Ambulatory blood pressure monitoring (ABPM) has been shown to be associated with cognitive functioning in both adults and children with hypertension. Few studies have examined this relationship in youth with normal to mildly elevated blood pressure (BP). We aimed to address this gap in the literature by examining the relationship between average wake systolic BP and targeted cognitive abilities in children and adolescents with normal to mildly elevated BP.

Design:
Cross-sectional cohort study across six academic centers in the United States.

Methods:
Participants were part of the SHIP AHOY Project examining target organ damage in children and adolescents with normal to mildly elevated BP. Patients were recruited from pediatric nephrology and/or cardiology clinics and had BP levels > 75th percentile to > 95th percentile). Ascertainment was designed to balance BMI across this BP range by actively recruiting normotensive subjects with obesity. Exclusion criteria included stage 2 hypertension, use of antihypertensive or lipid-lowering medication in the past 6 months, diabetes mellitus (type 1 or 2), kidney disease, or other chronic medical conditions. The primary exposure for this study was average wake Systolic BP. Cognitive variables included the Test of Nonverbal Intelligence, Woodcock-Johnson-V Verbal Attention, and Conners Continuous Performance Test-3 Errors of Omission and Errors of Commission. Preliminary analyses comprised the use of unadjusted linear regressions for the entire sample, with follow-up analyses planned to include key covariates for any significant findings.

Results:
We recruited 397 adolescents, ages 11–19 years (M∼15.5 yrs.), who comprised approximately 60% males and 53% white. About 25% of the participants had caregivers with a high school degree or less. About 40% of the sample had elevated BP (> 90th percentile).
There was a significant relationship between wake average systolic BP and Verbal Attention (p < .009); and wake average systolic BP and Errors of Commission (p < .026). All findings were in the expected direction with higher average wake BP being related to lower performance on the attention-related variables. SBP and Errors of Omission approached significance (p < .07), while Nonverbal IQ was nonsignificant (p < .34).

Conclusions:
Higher average wake BP, even in adolescents with BP below the hypertensive range, is associated with lower performance on tests of attention regulation and response inhibition. These findings suggest that efforts to minimize associated neurocognitive dysfunction in the late adolescence and young adult years should begin before the presence of hypertension.