bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real‐world data for lenalidomide maintenance in responding patients of diffuse large B‐cell lymphoma
Authors: Wang Xiaoyan , Yu Lu , Jiang Xinlu , Ding Kaiyang 
Published: March 2023

AbstractBackgroundApproximately 40% patients of diffuse large B‐cell lymphoma (DLBCL) would develop disease recurrence/progression after first‐line R‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) induction therapy, with highly poor prognosis. An effective strategy to prolong the survival of this patient population is the additional single‐drug maintenance therapy. lenalidomide, an immunomodulatory drug with oral activity, has direct anti‐tumor activity and indirect effects mediated by multiple immune cells in the tumor microenvironment, such as B, T, natural killer (NK), and dendritic cells. Combining its controllable toxicity, it is promising in long‐term maintenance therapy. This study aims at evaluating the clinical effect of lenalidomide maintenance therapy in responding DLBCL patients with R‐CHOP treatment.MethodsThis retrospective study was devised in DLBCL cases who obtained complete response (CR) or partial response (PR) following 6–8 cycles of R‐CHOP treatment between January 1, 2015 and July 31, 2019. Patients (n = 141) included were respectively assigned to receive lenalidomide maintenance treatment (lenalidomide, n = 50) and drug‐free maintenance treatment (control, n = 91) after CR/PR. lenalidomide was provided orally at 25 mg/day for 10 days, with a cycle of 21 days and a treatment course of 2 years. Progression‐free survival (PFS) was taken as the primary outcome.ResultsOf the total 141 subjects, the median follow‐up time was 30.9 months (range, 5.7–68.9 months). The 2‐year PFS was 84% (95% CI: 74%–94%) in the lenalidomide group and 53% (95% CI: 43%–63%) in the control group. The median PFS of the lenalidomide group was not reached, and that of the control group was 42.9 months (HR = 0.32; 95% CI: 0.16–0.63; p = 0.001). No remarkable difference in overall survival (OS) between the two groups was indicated (HR = 0.42; 95% CI: 0.16–1.12; p = 0.08). Central nervous system (CNS) recurrence happened in 5 patients (5.5%) of the control group, while none of the patients with lenalidomide had CNS recurrence. Additionally, neutropenia and cutaneous reactions were the most common Grade 1–2 adverse reactions after lenalidomide treatment, and neutropenia was the most frequent Grade 3–4 adverse reaction.ConclusionTwo‐year lenalidomide maintenance treatment can significantly prolong the PFS of DLBCL patients who obtained CR/PR to first‐line R‐CHOP treatment.
Starch fine molecular structures as driving factors for multiphasic starch gelatinization property in rice flour
Authors: Li Cheng , Yi Xueer , Yang Chuantian , Li Enpeng 
Published: March 2023

AbstractBackground and ObjectivesAlthough the gelatinization property of isolated rice starch has been investigated in terms of its relationship to starch fine molecular structures, it remains unclear how these structures determine the gelatinization property of rice flour. The gelatinization properties of 10 rice flours with varying chain‐length distributions were thus studied.FindingsRice flours with larger amylose molecules, longer and higher amount of amylopectin intermediate chains showed double gelatinization peaks. The onset and peak temperatures of gelatinization for the peak having a lower gelatinization temperature showed a positive correlation with the molecular size of amylopectin. Conversely, the conclusion temperature of gelatinization for the peak with a higher gelatinization temperature exhibited a negative correlation with the molecular size of amylose and a positive correlation with the quantity of amylose and amylopectin intermediate chains. These correlations were largely different compared with those for rice flours with a single gelatinization peak.ConclusionsThese results supplied the first associations between gelatinization property of rice flour and starch fine molecular structures, which were different from those for pure rice starches.Significance and NoveltyThese results have the potential to assist the food industry in developing rice products with improved quality, depending on the molecular structure of the starch.
Eletrocarboxylation Reactions Using CO2 Both as Promoter and Carboxylative Reagent
Authors: Zhang Ke , Liu Xiao‐Fei , Ren Wei‐Min , Lu Xiao‐Bing , Zhang Wen‐Zhen 
Published: March 2023

AbstractElectrocarboxylation reaction, which employs organic electrosynthesis to achieve the utilization of CO2 as a carboxylative reagent, provides a powerful and efficient tool for the preparation of organic carboxylic acid. In some electrocarboxylation reactions, CO2 also acts as a promoter to facilitate the desired reaction. This concept mainly highlights recent CO2‐promoted electrocarboxylation reactions via CO2⋅− intermediate or transiently protective carboxylation of active intermediate with CO2.
Pd−Bi Bimetallic Nanochains for Electroreduction of CO2 to Syngas in Ionic Liquid‐Based Electrolytes
Authors: Yang Han , Zhang Renjie , Yang Jie , Zhou Guangying , Jia Xiaoyan , Hua Zhixin , Yang Dexin 
Published: March 2023

AbstractThe electroreduction of carbon dioxide (CO2) is a sustainable method for generating valuable chemicals; however, avoiding unwanted hydrogen (H2) production during the electrolysis is a major challenge. Coproduction of carbon monoxide (CO) and H2 to produce syngas is an effective strategy for solving this problem, and syngas with a desired CO/H2 ratio can be employed to produce methanol or other valuable chemicals. Herein, a series of palladium‐bismuth (Pd−Bi) bimetallic nanochains with different Pd/Bi atomic ratios were prepared and used in the electroreduction of CO2 to syngas in ionic liquid‐based electrolytes. The ratio of CO/H2 in syngas was regulated in a wide range from 1 : 7 to 9 : 1 by controlling the applied potentials, Pd/Bi atomic ratios and composition of the electrolytes. In particular, the current density reached 19.3 mA cm−2 on Pd3Bi bimetallic nanochains at an applied potential of −2.3 V versus Ag/Ag+ when the CO/H2 ratio was approximately 1 : 1. Moreover, the maximum CO Faradaic efficiency was 87.7 % for these electrocatalysts at an applied potential of −2.0 V versus Ag/Ag+. The synergistic effect of Pd and Bi in the ionic liquid‐based electrolyte was the primary reason for the distinct electrocatalytic efficiency of the Pd3Bi bimetallic nanochains. The incorporation of moderate amounts of Bi into the Pd lattice resulted in a stronger CO2 adsorption capacity, more active sites and faster electron transfer rate, which are conducive to improving the electrocatalytic activity.
Malignancy in pregnancy: Multimodality imaging and treatment
Authors: Nguyen Trinh , Bhosale Priya R. , Cassia Lorena , Surabhi Venkateswar , Javadi Sanaz , Milbourne Andrea , Faria Silvana C. 
Published: March 2023

AbstractThe diagnosis of cancer is increasingly made in the pregnant population, thought to be from the increasing average age of pregnancy and the use of prenatal fetal noninvasive screening techniques, leading to incidental detection of cancer in the mother. Complex challenges are associated with imaging, diagnosis, staging, and treatment of cancers in this patient population, which require highly specialized interdisciplinary management. This report discusses the use of multimodality imaging and safety considerations in pregnant patients, reviews the current guidelines for ionizing radiation imaging techniques, and presents a series of commonly and uncommonly encountered cancers in pregnancy with current diagnostic imaging guidelines. The authors also discuss the role of multidisciplinary management and treatment options and provide an overview of therapy‐related considerations in the age of novel anticancer therapies.Plain Language Summary

The diagnosis and management of pregnant patients who have cancer are actively evolving as novel imaging techniques and anticancer therapies are being developed.

Radiologically, there are inherent difficulties in balancing the minimization of fetal ionization while acquiring diagnostic quality imaging necessary for the diagnosis, staging, and treatment of maternal disease.

Standardized imaging protocols are still being developed, with evolving imaging guidelines coupled with rapidly expanding research and development of novel anticancer therapies, which come with their side effects and complications.

Caring for this patient population is especially challenging and requires specialized multidisciplinary attention.
Solid‐Supported Membrane (SSM)‐Based Electrophysiology Assays Using Surface Electrogenic Event Reader Technology (SURFE²R) in Early Drug Discovery
Authors: Pommereau Antje , Licher Thomas , Bärenz Felix 
Published: March 2023

AbstractThis article presents detailed descriptions of procedures and troubleshooting tips for solid‐supported membrane (SSM)‐based electrophysiology assays (SURFE²R) to measure electrogenic solute carrier transporter proteins (SLCs) and assess the effects of compounds that modulate their activity. SURFE²R allows the use of the standard 96‐well format, making it an ideal platform for tertiary assays in a drug‐discovery campaign. The assays are performed with cell‐line‐derived membrane fractions or proteoliposomes containing the transporter of interest. Three main protocols are described for the isolation of membrane fractions from cell culture and the generation of proteoliposomes containing the transporter of interest. Additionally, detailed protocols for SURFE²R single concentration and dose‐response experiments are included to measure the potencies of test compounds in stimulating or inhibiting transporter function (EC50 or IC50 values, respectively) and kinetic functional assays to calculate apparent affinity (kM) and maximal velocity (Vmax) of substrate uptake. © 2023 Sanofi. Current Protocols published by Wiley Periodicals LLC.This article was corrected on 23 March 2023. See the end of the full text for details.PROTOCOL GROUP 1: Sample preparation for SSM‐based electrophysiology assaysSupport Protocol 1: Production of cell batchesSupport Protocol 2: Simple isolation of cell membranesAlternate Protocol 1: Isolation of cell membranes with sucrose gradient pre‐purificationSupport Protocol 3: Production and isolation of liposomesSupport Protocol 4: Preparation of sensor with isolated cell membranesAlternate Protocol 2: Preparation of sensor with isolated proteoliposomesPROTOCOL GROUP 2: Determination of assay parameters for SSM‐based electrophysiology assaySupport Protocol 5: Assay with stable bufferAlternate Protocol 3: Assay with ion gradientSupport Protocol 6: Determination of membrane/liposome concentrationSupport Protocol 7: Determination of substrate dependency kMPROTOCOL GROUP 3: Determination of advanced assay parameters for SSM‐based electrophysiology assaysSupport Protocol 8: Assessment of ion concentration dependencySupport Protocol 9: Assessment of pH dependencySupport Protocol 10: Assessment of DMSO dependencySupport Protocol 11: Assessment of signal stability with multiple activationsPROTOCOL GROUP 4: Compound testing through SSM‐based electrophysiology assays using SURFE²R apparatusSupport Protocol 12: Assessment of signal specificity of a published inhibitor or unknown compound(s)Support Protocol 13: Compound wash‐outSupport Protocol 14: Statistical analysis
Effect of Ar Plasma Treatment on the Interface and Performance of CdZnTe Detectors
Authors: Cao Xiangzhi , Zhang Jijun , Wang Shulei , Xu Zheren , Wang Linjun 
Published: March 2023

AbstractThe performance of CdZnTe detectors is not only influenced by the growth of crystal, but also by the quality of the interface layer between the crystal and the electrode. A model of CdZnTe detector with metal–semiconductor–metal structure is developed to investigate the effects of the interface on the space charge and electric field distribution. Atomic force microscopy, current–voltage (I–V) analysis, and energy spectra under 241Am irradiation are adopted to investigate the effects of argon (Ar) plasma treatment on the interface and performance of CdZnTe detectors experimentally. The simulation results show that the interface layer with low density of surface state and thin thickness can form a more uniform space charge and electric field distribution. Due to the decrease of voltage drop across the interface, the leakage current at 200 V of CdZnTe detector with Ar plasma treatment is reduced from 159 to 44 nA cm−2, and the full‐width at half‐maximum under 241Am is improved from 9.3% to 8.2%, as compared to conventional Br‐MeOH treatment.
Board gender diversity and environmental, social and governance (ESG) disclosure: Is it different for developed and developing nations?
Authors: Wasiuzzaman Shaista , Subramaniam Vasanthan 
Published: March 2023

AbstractThis paper examines the influence of board gender diversity on the Environmental, Social and Governance (ESG) disclosure quality of energy firms. Particularly, the study evaluates the possible differences in the influence of board gender diversity on the ESG disclosure practice of firms in developed and developing nations. Previous studies have used single country based analysis and presented diverse results, however this study uses data from 48 countries from both developed and developing nations over a period of 13 years (from year 2004 to 2016). The study finds that, in general, female directors favorably influence the quality of disclosure of ESG and its individual components (except governance). However, sub‐sample analysis of firms in developed and developing nations finds that the relationships are significant only for the sample of firms in developed nations. The results show that there are differences in the role female directors play in influencing ESG disclosure for developed and developing countries, thus this study highlights the importance of accounting standards in strengthening the contribution of female directors on corporate boards, especially in developing countries. The study also highlights the need to assess ESG components separately, in addition to the overall component, when conducting studies on ESG.
Time‐dependent charged particle stopping in quantum plasmas: testing the G1–G2 scheme for quasi‐one‐dimensional systems
Authors: Makait C. , Fajardo F. Borges , Bonitz M. 
Published: March 2023

AbstractWarm dense matter—an exotic, highly compressed state on the border between solid and plasma phases is of high current interest, in particular for compact astrophysical objects, high‐pressure laboratory systems, and inertial confinement fusion. For many applications, the interaction of quantum plasmas with energetic particles is crucial. Moreover, often the system is driven far out of equilibrium. In that case, there is high interest in time‐dependent simulations to understand the physics, in particular, during thermalization. Recently a novel many‐particle technique, the G1–G2 scheme was presented with reference to the study by Schlünzen et al. (2020) which allows for first‐principle simulations of the time evolution of interacting quantum systems. Here we apply this scheme to a spatially uniform dense quantum plasma (jellium) and explore its performance. To this end, the G1–G2 scheme is transformed into momentum representation, and first results are presented for a quasi‐one‐dimensional model system.
Effect of olive oil phenols on oxidative stress biomarkers: A systematic review and dose–response meta‐analysis of randomized clinical trials
Authors: Derakhshandeh‐Rishehri Seyedeh‐Masomeh , Kazemi Asma , Shim Sung Ryul , Lotfi Mostafa , Mohabati Shabnam , Nouri Mehran , Faghih Shiva 
Published: March 2023

AbstractThe phenolic content of olive oil has a role in cardiovascular protection. Some clinical trial studies demonstrated that phenolic compounds of olive oil have antioxidant activity which can protect macronutrients from oxidative damages. The aim of this study was to summarize the results of clinical trials which assessed the effects of high‐ versus low‐phenol olive oil on oxidative stress biomarkers levels. We searched Scopus, PubMed, Web of Science, Google Scholar, ProQuest, and Embase up to July 2021. Eight clinical trials which evaluated the effect of the phenolic content of olive oil on oxidized‐LDL (ox‐LDL), malondialdehyde (MDA), or ferric‐reducing ability of plasma (FRAP) were included the meta analysis. A significant decrease was observed in ox‐LDL level (WMD: −0.29 U/L; 95% CI: −0.51, −0.07) and MDA (WMD: −1.82 μmoL/L; 95% CI: −3.13, −0.50). However, after subgroup analysis for MDA, the result was not significant for not serious limitation (SMD: −0.05, 95% CI: −0.35 to 0.24), but significant for serious limitation (SMD: −3.64, 95% CI: −4.29 to −2.99). Also, no significant change was found in FRAP (WMD: 0.0 mmoL/L; 95% CI: −0.03, 0.04) level. Dose–response analysis indicated a significant linear relationship between the phenolic content of olive oil and ox‐LDL. The present study showed some beneficial effects of high‐phenol compared with low‐phenol olive oil on ox‐LDL and MDA levels. According to the meta‐regression analysis along with the increasing phenolic content of olive oil, a reduction in oxidative stress biomarkers was observed.
Critical path planning for discharging older adults using a functional perspective
Authors: Salehi Vahid , Veitch Brian , Smith Doug 
Published: March 2023

AbstractThis study aims to introduce an innovative method to schedule and analyze the discharge planning processes under uncertain individual activity completing times. Hospital care processes ending in discharging older adults represent a major challenge, as a number of interrelated tasks or activities are involved in the processes. The functional resonance analysis method (FRAM) is used to identify activities that constitute a descriptive model of the discharge planning processes and to assign the completion time to each task or activity. Then the critical path planning technique is utilized to identify the critical path of the discharge process. To this end, the Program Evaluation and Review Technique (PERT) is employed. Published data regarding six older patients are used to examine the potential utility of the introduced method to improve the discharge process of older adults. The results show that the integration of the FRAM and PERT is able to identify the critical activities that constitute the critical path of the discharge process. It also helps analyze the completion time assigned to each task/activity and calculate the completion time of the discharge process. The probability of completing the discharge process within a target completion time is also discussed. The results add further evidence showing the applicability of the FRAM and PERT to scheduling systems for the discharge planning processes. Health care professionals could use the findings of this study in designing a scheduling system to complete the discharge process of older adults in a reasonable time.
Fanconi anemia‐isogenic head and neck cancer cell line pairs: A basic and translational science resource
Authors: Nguyen Hiep Tai , Tang Weiliang , Webster Andrew L. H. , Whiteaker Jeffrey R. , Chandler Christopher M. , Errazquin Ricardo , Roohollahi Khashayar , Fritzke Madeline , Hoskins Elizabeth E. , Jonlin Erica , Wakefield Leslie , Sullivan Lucas B. , Chen Eleanor Y. , Dorsman Josephine , Brakenhoff Ruud , Paulovich Amanda G. , Grompe Markus , Garcia‐Escudero Ramon , Wells Susanne I. , Smogorzewska Agata , Monnat Raymond J. 
Published: March 2023

AbstractFanconi anemia (FA) is a heritable malformation, bone marrow failure and cancer predisposition syndrome that confers an exceptionally high risk of squamous carcinomas. These carcinomas originate in epithelia lining the mouth, proximal esophagus, vulva and anus: their origins are not understood, and no effective ways have been identified to prevent or delay their appearance. Many FA‐associated carcinomas are also therapeutically challenging: they may be multi‐focal and stage‐advanced at diagnosis, and most individuals with FA cannot tolerate standard‐of‐care systemic therapies such as DNA cross‐linking drugs or ionizing radiation due to constitutional DNA damage hypersensitivity. We developed the Fanconi Anemia Cancer Cell Line Resource (FA‐CCLR) to foster new work on the origins, treatment and prevention of FA‐associated carcinomas. The FA‐CCLR consists of Fanconi‐isogenic head and neck squamous cell carcinoma (HNSCC) cell line pairs generated from five individuals with FA‐associated HNSCC, and five individuals with sporadic HNSCC. Sporadic, isogenic HNSCC cell line pairs were generated in parallel with FA patient‐derived isogenic cell line pairs to provide comparable experimental material to use to identify cell and molecular phenotypes driven by germline or somatic loss of Fanconi pathway function, and the subset of these FA‐dependent phenotypes that can be modified, complemented or suppressed. All 10 FANC‐isogenic cell line pairs are available to academic, non‐profit and industry investigators via the “Fanconi Anemia Research Materials” Resource and Repository at Oregon Health & Sciences University, Portland OR.
Prostate sarcoma
Authors: Ehat Nicholas T , Chuong Lisa , Dickman Jenna , Deng Tom , Chang George , Hwang Jonathan 
Published: March 2023

IntroductionThis report is intended to provide insight into the presentation, diagnosis, and treatment of prostatic sarcomas. A literature review is included to compare variables in demographics, histology, prognosis, and treatment strategies among previously reported incidences.Case presentationIn this case, we have a 72‐year‐old man who initially presented with symptomatic nephrolithiasis that led to further workup. Magnetic resonance imaging revealed an enlarged, heterogeneous prostate with a dominant mass in the left lobe. A biopsy of the prostate revealed a high‐grade, undifferentiated sarcoma in the left lobe along with concomitant adenocarcinoma in the right lobe.ConclusionsThe patient underwent a radical prostatectomy, which according to existing literature remains the most effective treatment strategy. Staging is the most important prognostic indicator, making this cancer particularly dangerous as presenting symptoms are highly variable among patients.
Retroauricular lymph node flap: An anatomic and surgical feasibility study
Authors: Roka‐Palkovits Julia , Freystätter Christian , Tinhofer Ines E. , Keck Maike , Steinbacher Johannes , Meng Stefan , Weninger Wolfgang J. , Cheng Ming‐Huei , Tzou Chieh‐Han J. 
Published: March 2023

AbstractBackgroundThe study investigated the anatomy of the retroauricular lymph node (LN) flap and evaluate its surgical feasibility as a new donor site for a free LN flap in lymphedema surgery.MethodsTwelve adult cadavers were examined. The course and perfusion of the anterior auricular artery (AAA) and the location and sizes of the retroauricular LNs were studied.ResultsThe AAA was available in 87% and absent in 13% specimens. The AAA's origin had a mean vertical distance of 12.2 ± 6.9 mm and a mean horizontal distance of 19.1 ± 4.2 mm from the superior attachment of the ear. The mean diameter of the AAA was 0.8 ± 0.2 mm. The mean number of LN per region was 7.7 ± 2.3, with an average LN size of 4.1 ± 1.9 × 3.2 ± 1.7 mm. The LN were categorized into anterior (G1) and posterior (G2) groups, with a total of 59 and 10 LN, respectively. In a cluster analysis, three LN clusters could be detected across the anterior group (G1).ConclusionsThe retroauricular LN flap is a delicate but feasible flap with reliable anatomy, containing a mean of 7.7 LNs.