bluuebunny/crossref_metadata_2025_split huggingface dataset:
(Cost-)effectiveness of a Personalized Multidisciplinary eHealth Intervention for Knee Arthroplasty Patients to Enhance Return to Activities of Daily life, Work and Sports – Rationale and Protocol of the Multicentre ACTIVE Randomized Controlled Trial
Authors: Straat A. Carlien , Maarleveld Jantine M. , Smit Denise J.M. , Visch Lara , Hulsegge Gerben , Huirne Judith A.F. , Dongen J. M. van , Geenen Rutger C. van , Kerkhoffs Gino M.M.J. , Anema Johannes R. , Coenen Pieter , Kuijer P. Paul F. M. 
Published: February 2023

Abstract
Background
With the worldwide rising obesity epidemic and the aging population, it is essential to deliver (cost-)effective care that results in enhanced societal participation among knee arthroplasty patients. The purpose of this study is to describe the development, content, and protocol of our cost-effectiveness study that assesses a perioperative integrated care program, including a personalized eHealth app, for knee arthroplasty patients aimed to enhance societal participation post-surgery compared to care as usual.
Methods
The intervention will be tested in a multicentre randomized controlled trial with eleven participating Dutch medical centers (i.e., hospitals and clinics). Working patients on the waiting-list for a total- or unicompartmental knee arthroplasty with the intention to return to work after surgery will be included. After pre-stratification on medical centre with or without eHealth as usual care, operation procedure (total- or unicompartmental knee arthroplasty) and recovery expectations regarding return to work, randomization will take place at the patient-level. A minimum of 138 patients will be included in both the intervention and control group, 276 in total. The control group will receive usual care. On top of care as usual, patients in the intervention group will receive an intervention consisting of three components: 1) a personalized eHealth intervention called ikHerstel (‘I Recover’) including an activity tracker, 2) goal setting using goal attainment scaling to improve rehabilitation and 3) a referral to a case-manager. Our main outcome is quality of life, based on patient-reported physical functioning (using PROMIS-PF). (Cost-)effectiveness will be assessed from a healthcare and societal perspective. Data collection has been started in 2020 and is expected to finish in 2024.
Discussion
Improving societal participation for knee arthroplasty is relevant for patients, health care providers, employers and society. This multicentre randomized controlled trial will evaluate the (cost-)effectiveness of a personalized integrated care program for knee arthroplasty patients, consisting of effective intervention components based on previous studies, compared to care as usual.
Trial registration
trialsearch.who.int; reference no. NL8525, reference date version 1: 14-04-2020
Hematological Indicator-Based Machine Learning Models for Preoperative Prediction of Lymph Node Metastasis in Cervical Cancer
Authors: Zhao Huan , Wang Yuling , Sun Yilin , Wang Yongqiang , Zhang Sai , Liu Jian , Shi Bo 
Published: February 2023

Abstract
Background
Lymph node metastasis (LNM) is an important prognostic factor for cervical cancer (CC) and determines the treatment strategy. Hematological indicators have been reported as being useful biomarkers for the prognosis of a variety of cancers. This study aimed to evaluate the feasibility of machine learning models characterized by preoperative hematological indicators to predict the LNM status of CC patients before surgery.
Methods
The clinical data of 236 patients with pathologically confirmed CC were retrospectively analyzed at the Gynecology Oncology Department of the First Affiliated Hospital of Bengbu Medical College from November 2020 to August 2022. Recursive feature elimination (RFE) was used to select 12 features from 35 hematological indicators and for the construction of 6 machine learning predictive models, including Adaptive Boosting (AdaBoost), Gaussian Naive Bayes (GNB), and Logistic Regression (LR), as well as Random Forest (RF), Support Vector Machines (SVM), and Extreme Gradient Boosting (XGBoost). Evaluation metrics of predictive models included the area under the receiver operating characteristic curve (AUC), accuracy, precision, recall, and F1-score.
Results
There was no significant difference in the 10-fold cross-validated AUC between XGBoost and RF (XGBoost, AUC = 0.903 vs. RF, AUC = 0.908; P = 0.889, DeLong test). XGBoost showed the best overall predictive performance. The specific performance indicators of XGBoost were AUC (0.903, 95% CI: 0.829–0.977), accuracy (0.841, 95% CI: 0.759–0.923), precision (0.850, 95% CI: 0.774–0.926), recall (0.837, 95% CI: 0.755–0.919), and F1-score (0.832, 95% CI: 0.739–0.925).
Conclusions
XGBoost and RF based on preoperative hematological indicators that are easily available in clinical practice showed superior performance in the preoperative prediction of CC LNM. However, investigations on larger external cohorts of patients are required for further validation of our findings.
Related factors and characteristics of malocclusion in Japanese preschool children aged 3–6 years
Authors: Otsugu Masatoshi , Sasaki Yumi , Mikasa Yusuke , Kadono Maika , Sasaki Hidekazu , Kato Takafumi , Nakano Kazuhiko 
Published: February 2023

Abstract
Background
Malocclusion is a multifactorial condition associated with genetic and environmental factors. The purpose of this study was to investigate the prevalence of occlusal traits, oral habits, and nose and throat conditions by age and to assess the association between malocclusion and its environmental factors in Japanese preschool children.
Methods
A total of 503 Japanese children (258 boys and 245 girls aged 3–6 years) were recruited. Occlusal traits were assessed visually to record sagittal, vertical, and transverse malocclusion, and space discrepancies. Lip seal was recorded by an examiner, and oral habits (finger sucking, lip sucking or lip biting, nail biting, chin resting on a hand) and nose and throat conditions (tendency for nasal obstruction, allergic rhinitis, palatine tonsil hypertrophy) were assessed by a questionnaire completed by the parents. The prevalence of each item was calculated, and binary logistic regression was used to examine the factors related to malocclusion.
Results
62.0% of preschool children in the present study exhibited malocclusion, and 27.8% exhibited incompetent lip seal. Nail biting was the most frequent oral habit with a prevalence of 18.9%. Nasal obstruction was recorded in 30.4% of children. The results of binary logistic regression showed that incompetent lip seal was significantly related to malocclusion, and that nail biting was significantly negatively related.
Conclusions
Incompetent lip seal is significantly associated with malocclusion, but nail biting may not necessarily be a deleterious habit for the occlusion in Japanese preschool children.
Inter-species and inter-pathology self-supervised pre-training of deep learning models: a resource to improve the classification of veterinary thoracic radiographs
Authors: Celniak Weronika , Wodziński Marek , Jurgas Artur , Burti Silvia , Zotti Alessandro , Atzori Manfredo , Müller Henning , Banzato Tommaso 
Published: February 2023

Abstract
Analysis of veterinary radiographic imaging data is an essential step in the diagnosis of many thoracic lesions. Given the limited time that practitioners can devote to a single patient, it would be valuable to implement an automated system to help clinicians make faster but still accurate diagnoses. Currently, most of such systems are based on supervised deep learning approaches. However, the problem with these solutions is that they need a large database of labelled data. Access to such data is often limited, as it requires a great investment of both time and money. Therefore, in this work we present a solution that allows higher classification scores to be obtained using knowledge transfer from inter-species and inter-pathology self-supervised learning methods. Before training the network for classification, pretraining of the model was performed using self-supervised learning approaches on publicly available unlabelled radiographic data of human and dog images, which allowed to substantially increase the number of images for this phase. %Manfredo: to be checkedThe self-supervised learning approaches included the Beta Variational Autoencoder, the Soft-Introspective Variational Autoencoder, and a Simple Framework for Contrastive Learning of Visual Representations. After the initial pretraining, fine-tuning was performed for the collected veterinary dataset using 20\% of the available data. Next, a latent space exploration was performed for each model after which the encoding part of the model was fine-tuned again, this time in a supervised manner for classification. Simple Framework for Contrastive Learning of Visual Representations proved to be the most beneficial pretraining method. Therefore, it was for this method that experiments with various fine-tuning methods were carried out. We achieved mean ROC AUC score of 0.77 and 0.66 respectively for LL and DV projection dataset. The results show significant improvement compared to using model without any pretraining approach.
Relationship between occupational exposure and clinical features of chronic obstructive pulmonary disease（COPD）
Authors: Yuan Rui , Peng Cong , Chen Yao , Liu Jie , Xue Ning , Song Pingping , Yan Yongjian 
Published: February 2023

Abstract
Background: The effect of occupational risk factors on the clinical features of COPD is still unclear, and the purpose of this study was to analyze the effect of occupational exposure on the clinical features of COPD.
Methods: A total of 908 patients from Grade-A hospitals were analyzed as study subjects, and self-reported occupational exposure was recorded.
Results:A total of 258 COPD patients (28.4%) were exposed to VGDF. Several characteristics were significantly associated with VGDF exposure: respiratory symptoms such as cough and sputum, airflow limitation, and mMRC score of 2-4 (41.1%vs32.3%, P＜0.05); CAT score (17.45±1.683 vs 16.61±2.402, P＜0.001). As COPD patients' exposure to occupational factors increased, so did the incidence of respiratory symptoms (P＜ 0.05).
Conclusions: In this series of COPD patients, subjects exposed to VDGF had more severe clinical symptoms, including respiratory symptoms, severity of airflow restriction, and CAT score. In occupational risk factor exposure, exposure level is the main influencing factor.
Ten-year evaluation of microbiological contamination on surfaces in three operational realities in the food sector for improvement of preventive actions.
Authors: marras luisa , bertolino giacomo , Sanna Adriana , Coroneo Valentina 
Published: February 2023

Abstract
Food sector operators are responsible for monitoring the production cycle in order to offer a safe product from a sanitary point of view for marketing and consumption. The main goal of the work was to evaluate the degree of contamination of various surfaces in different production companies and therefore the effectiveness of the sanitization procedures performed at critical points in the aforesaid process (CCPs). As a result of this initial analysis, suggestions are then made on how to strengthen the prevention and reduce the risk of microbial contamination of the entire workflow and also on how to prevent foodborne infectious diseases and drug resistance. The analytical investigation activity was carried out in our province in the period between 2011–2020 and involved commercial catering environments, large-scale distribution, small retail centers and small producers. Significant differences emerged from the results regarding the contamination of surfaces in the operational situations considered (contamination with Enterobacteriaceae spp. was more frequent in retail centers than in the other food sectors (16.3% vs 33.0%; p < 0.001) whilst a higher possibility of finding a positive sample was more probable for large-scale distribution equipment (24.3% vs 40.4%; p = 0.005). It was also observed how the collecting technique performed by contact plate gave more positive results than collecting samples with a swab (10.1% vs 5.7%; p = 0.002) and how some types of surfaces require more attention. In conclusion, from a risk prevention perspective, the results were satisfactory but could be further implemented through better sanitization practices that were recommended in the event of positive sampling.
Ethylene glycol intoxication presenting as a mimic of acute stroke: report of three cases
Authors: Héja Máté , Oláh László 
Published: February 2023

Abstract
Background: Stroke is a major cause of death and disability presenting with acute focal neurological symptoms of vascular origin. Several other disorders may cause symptoms similar to a stroke, referred as stroke mimics. Misdiagnosis of stroke mimics may lead to potentially harmful treatments, including thrombolysis. Intoxication is a rare, but possible cause of stroke mimic. We present three cases of ethylene glycol poisoning presenting as acute stroke mimic within the time window of thrombolytic therapy.
Case presentations: The first patient (54-year-old, male) had nystagmus, dysarthria and truncal ataxia on admission. Cerebral CT and CT-angiography were negative. Vertebrobasilar stroke was suspected and intravenous thrombolysis was performed. A few hours later confusion, somnolence and hyperventilation developed. Arterial blood gas analysis showed metabolic acidosis. Toxicology screening revealed the presence of ethylene glycol in a toxic range. Due to the prompt treatment the patient was discharged 9 days later in a symptom-free state. The second patient (78-year-old, male) was admitted with central type of nystagmus, gaze palsy, dysarthria and ataxia. In the absence of exclusion criteria, thrombolysis was performed. A few hours later his condition deteriorated, he became comatose and tetraplegic with partially absent brainstem reflexes. Arterial blood gas analysis revealed severe metabolic acidosis. The ethylene glycol level was 159 mg/dL. Despite the appropriate treatment, he died. The third patient (54-year-old, male) with a history of chronic alcoholism was presented after an epileptic seizure with mixed aphasia and confusion. Stroke could not be excluded, therefore thrombolysis was performed. Arterial blood gases were normal, however toxicological screening revealed a serum etyhlene-glycol concentration of 16,54 mg/dL. Six days after admission he became symptom-free and was discharged home.
Conclusions: Our cases show that ethylene glycol intoxication in its early phase may mimic acute stroke resulting in an unnecessary thrombolytic therapy. Symptoms not characteristic of a stroke, such as hyperventilation, agitation, and disturbance of consciousness, may appear later and warn of intoxication. The final diagnosis of ethylene-glycol intoxication can be established by a severe metabolic acidosis and toxicological screening. Close monitoring of symptoms might contribute to early recognition of ethylene-glycol intoxication and its effective treatment.
Headache following vaccination against COVID-19 among healthcare workers with a history of COVID-19 infection: A cross-sectional study in Iran with a meta-analytic review of the literature
Authors: Nasergivehchi Somayeh , Togha Mansoureh , Jafari Elham , Sheikhvatan Mehrdad , Shahamati Donya 
Published: February 2023

Abstract
Background: There is evidence of the occurrence of headache after vaccination against COVID-19. However, only a few studies have examined the headache characteristics and related determinants, especially among healthcare workers with a history of COVID-19 infection.
Methods: We evaluated the incidence of headaches after injection of different types of COVID-19 vaccine to determine factors relating to the incidence of headache after vaccination among the Iranian healthcare workers who had previously contracted COVID-19. A group of 334 healthcare workers with a history of COVID-19 infection were included and vaccinated (at least one month after recovery without any COVID-19 related symptoms) with different COVID-19 vaccines. The baseline information, headache characteristics and vaccine specifications were recorded.
Results: Overall, 39.2% reported experiencing a post-vaccination headache. Of those with a previous history of headache, 51.1% reported migraine-type, 27.4% tension-type and 21.5% other types. The mean time between vaccination and headache appearance was 26.78±6.93 h, with the headache appearing less than 24 h after vaccination in most patients (83.2%). The headaches reached its peak within 8.62±2.41 hours. Most patients reported a compression-type headache. The prevalence of post-vaccination headaches was significantly different according to the type of vaccine used. The highest rates were reported for AstraZeneca, followed by Sputnik V. In regression analysis, the vaccine brand, female gender and initial COVID-19 severity were the main determinants for predicting post-vaccination headache.
Conclusion: Participants commonly experienced a headache following vaccination against COVID-19. Our study results indicated that this was slightly more common in females and in those with a history of severe COVID-19 infection.
On some new weighted maximal operators of Fejér means of Walsh-Fourier series
Authors: Areshidze Nika , Baramidze Davit Davit , Persson Lars-Erik , Tephnadze George 
Published: February 2023

Abstract
In this paper we introduce and investigate a new restricted weighted maximal operator of Fejér means of Walsh-Fourier series and prove that the it is bounded from the martingale Hardy space H1/2(G) to the Lebesgue space L1/2(G). The sharpness of this result is also proved. As a consequence we obtain both some new and well-know results.
2020 Mathematics Subject Classification. 26015, 42C10, 42B30.
Roles of the structural units, glycotopes / mammalian N-glycans for Con A - Glycan interactions, their codes, and their recognition Factors
Authors: Wu Albert M. 
Published: February 2023

Abstract
The binding property of Con A has been studied intensively and applied widely to glycoconjugates / glycobiology for over 80 years. However, its role and functional relationship of Con A with these mammalian structural units, glycotopes, N-glycan chains, as well as their polyvalent forms in N-glycoproteins involved in the Con A- glycan interactions have not been all defined and organzied. In this study, the recognition factors involved in these inteactions were azalyzed by our well developed method- the enzyme linked lectinosorbent (ELLSA) and inhibition assay. Based on all data obtained, it is concluded that Con A, as previous report, has a relatively broad and wide recognition ability with the Manα1→ and Glcα1→ related glycans. In addition to it reacted strongly with yeast mannan and glycogens, it also bound well with a large number of mammalian N-glycans, including the N-glycans of rat sublingual gp (RSL), human Tamm-Horsfall glycoprotein (THGP), thyroglobin and lactosferrin. The recognition specificity of Con A towards ligands, expressed by Molar Relative Potency (Molar R.P.), in a decreasing order is as follows: a1→3, a1→6 Mannopentaose (M5) and Biantennary N-linked core pentasaccharide (MDi) ≥ a1→3, a1→6 Mannotriose (M3) > Mana1→3Man (α1→3Mannobiose), Mana1→2Man (α1→2Mannobiose), Mana1→6Man (α1→6Mannobiose), Mana1→4Man (α1→4Mannobiose) > GlcNAcb1→2Man (b1→2 N-Acetyl glucosamine-mannose) > Mana1→/Glcα1→ > Man > Glc, while Gal / GalNAc were inactive. Furthermore, the Man related code system, in this study, is proposed to express by both numbers of Man and GlcNAcb1→ branches (M3 to M9 / MMono to Penta etc.) and a table of three Mana1→ and Glca1→ related biomasses of six recognition factors involved in the Con A-glycan interactions has also been demonstrated. These themes should be one of the most valuable advances since 1980s.
Prevalence and risk factors of anxiety and depression in patients with liver cirrhosis during the COVID-19 pandemic
Authors: Zhu Kai , Zhang Xiaobo , Xiong Yingzhu , Zhuang Zhijie , Dai Minhui , Zhang Yuhua , Liu Zhonghe 
Published: February 2023

Abstract
Background
Patients with cirrhosis are prone to mental and psychological problems. However, data on mental and psychological problems in patients with cirrhosis during the coronavirus disease 2019 (COVID-19) pandemic are lacking. Therefore, we aimed to investigate the prevalence and risk factors of anxiety and depression in this population.
Methods
The Patient Health Questionnaire-9 Scale and Generalized Anxiety Disorder 7-item scale were used to collect mental health data in this cross-sectional study. Multivariate logistic regression analysis was performed to evaluate the relevant influencing factors of anxiety and depression.
Results
The prevalence rates of anxiety and depression in patients with cirrhosis were 21.3% and 29.9%, respectively. Anxiety risk was higher among patients with cirrhosis who had significant abdominal pain and treatment interruption; COVID-19 vaccination was associated with anxiety reduction as a protective factor. Depression risk was higher among patients with cirrhosis for > 10 years, significant abdominal pain within one week, and treatment interruption. Course of cirrhosis of 5–10 years and COVID-19 vaccination were associated with the reduction of depression as protective factors.
Conclusion
COVID-19 vaccination is a protective factor for both depression and anxiety. Our findings may help healthcare professionals to develop appropriate treatment strategies and timely psychological interventions.
Utilizing Modified Maize Cobs as an Agricultural Waste Adsorbent for Removing Zinc (II) and Chromium (VI) Ions from Wastewater
Authors: Kulmedov Begmyrat , Mohammed Ado 
Published: February 2023

Abstract
The purpose of this study is to investigate the use of maize cob carbon powder as an adsorbent for the removal of zinc (II) and chromium (VI) ions from industrial effluent. The non-degradable and toxic nature of these metal ions make their removal from wastewater crucial prior to discharge into the environment. Despite the many techniques that have been developed for the removal of heavy metals, many have proven to be inefficient, generate sludge, and are expensive. Adsorption processes have been shown to be one of the most efficient methods for the removal of toxic metal ions from contaminated water. Activated carbon is commonly used for this purpose but is expensive. Considering this, the search for more economical and safe options has led to the investigation of low-cost adsorbents as alternatives to activated carbon. In this study, maize cob carbon powder was chosen as the adsorbent due to its low cost, non-toxicity, and availability. A batch experimental approach was utilized to investigate the effects of temperature, pH, adsorbent loading, contact time, and initial metal ion concentration on the adsorption process. The results of the study indicate that maize cob carbon powder can be effectively used as an economical adsorbent for the treatment of contaminated water.