bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Acute Coronary Syndrome Care and in-hospital Outcome in a Resource-poor Setting in Northern Ghana
Authors: Yakubu Abdul-Subulr , Ahadzi Dzifa 
Published: July 2023

Abstract
Background
African countries are facing an epidemic of cardiovascular diseases for which they lack the resources to diagnose and manage adequately. Information on the quality of acute coronary syndrome care offered in underserved communities in low to middle-income countries like Ghana is limited. We examined the quality of acute coronary syndrome care offered to patients presenting to the Tamale Teaching Hospital in Northern Ghana.
Methods
We conducted a retrospective review of the medical records of patients ≥ 18 years with acute coronary syndrome managed in the Tamale Teaching Hospital of Northern Ghana from January 2021 to December 2022. We characterised the clinical profile of these patients and assessed in-hospital outcomes and the extent of compliance to key performance and quality indicators as contained in the 2017 American Heart Association /American College of Cardiology guideline for adults with myocardial infarction.
Results
Between January 2021 and December 2022, 62 patients with a mean age of 56.0 ± 16.1 years were admitted with acute coronary syndrome. Median time to hospital presentation after symptom onset was 24 hours (IQR 15–96 hours). 33.9% had ST-elevation myocardial infarction, of which only 14.3% received reperfusion therapy. About three-quarters of patients received dual antiplatelet therapy at discharge (78.2%), with fewer patients receiving recommended high-intensity statin therapy (65.5%) or beta-blockers (69.1%). Only 38.2% of patients had their left ventricular ejection fraction documented. Among those with documented left ventricular systolic dysfunction, 75% were prescribed an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker at discharge. No cardiac rehabilitation program existed. Risk stratification of patients with non-ST-elevation myocardial infarction or stress tests for conservatively managed patients was not part of routine practice.
Conclusion
Acute coronary syndrome management remains a challenging issue in Northern Ghana. Several gaps exist in the care quality, timeliness of interventions and rehabilitation of affected patients. There is an urgent need for measures to improve the delivery of acute coronary syndrome care alongside primary prevention strategies.
Construction of a Prognostic DNA Damage Repair Gene-related LncRNA Signature by Integrated Analysis of Bulk- and Single-cell RNA Sequencing Data in Lung Adenocarcinoma
Authors: Yu Lan , Xu Yan , Liu Li , Wang Yu , Zhang Hongmei , Li Jinyin , Liu Liancheng , Zhang Xiaotao 
Published: July 2023

Abstract
Despite the development of technology, the prognosis of patients with lung adenocarcinoma (LUAD) has not improved. Therefore, we sought to investigate the potential clinical utility of a risk prognosis model in prognostic stratification. For this purpose, DNA damage repair gene-related (DDRG-related) long noncoding RNAs (lncRNAs) were screened based on a single-cell RNA transcriptome to construct such a model. A total of 510 LUAD samples were selected from The Cancer Genome Atlas-LUAD (TCGA-LUAD) dataset. Samples were divided into two immune subtypes (S1 and S2) after calculating the stromal score, immune score, tumor purity, and immune infiltration in each TCGA-LUAD cohort based on the Estimation of Stromal and Immune cells in MAlignant Tumour tissues using Expression data (ESTIMATE) and the NbClust package. Subsequently, DDRG-related lncRNAs were selected by single-cell data analysis combined with bulk sequencing. Next, DDRG-related lncRNAs were screened through the least absolute shrinkage and selection operator, as well as univariate and multivariate Cox regression analyses to develop a precise DDRG-related-lncRNA prognosis risk model. The functions of the target genes of these lncRNAs were described by the Gene Ontology (GO) enrichment analysis. The prognostic capability of the model was tested by analyzing the expression data of LUAD samples downloaded from the Gene Expression Omnibus database. The correlations between tumor mutational burden, N6-methyladenosine (m6A) gene expression, risk score, and immune score were analyzed. A seven DDRG-related lncRNAs risk prognosis model was established. Based on the model, the TCGA-LUAD cohorts and testing sets were classified into low- and high-risk groups. The former group had better overall survival versus the latter group. In addition, a nomogram based on the risk score and clinical stage showed good calibration and moderate discriminative ability. Using single-cell transcriptome datasets, we constructed and verified a useful DDRG-related-lncRNA risk prognosis model for prognostic stratification in LUAD.
Advanced antimicrobial PCL/clay nanocomposite films: preparation, characterization, properties and degradation in simulated body fluid
Authors: Holešová Sylva , Barabaszová Karla Čech , Hundáková Marianna , Kratošová Gabriela , Joszko Kamil 
Published: July 2023

Abstract
Even though the biodegradability of polycaprolactone (PCL) and its nanocomposites is lower compared to other biodegradable polyesters, this property and its good biocompatibility are used in the development of materials for the drug delivery with a long-term effect. Thus, we prepared novel PCL/clay nanocomposite films with antimicrobials chlorhexidine diacetate (CH) or octenidine dihydrochloride (OCT) in combination with zinc oxide (ZnO), all anchored on vermiculite (VER). The structure of the prepared nanofillers for the PCL films was characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy and particle size analysis. Based on these methods, the intercalation of the CH and OCT into the interlayer of VER/ZnOVER was confirmed as well as the increase in particle size and formation of new fraction. Compared to VER, the resulting nanofillers showed a positive ζ-potential indicating a relatively stable material, but in the case of ZnOVER_OCT, its value dropped too much, which was confirmed by strong agglomeration of particles. Thin PCL/clay nanocomposite films were prepared by solvent casting and evaporation method and the effect of used nanofillers on structural, thermal, mechanical and antimicrobial properties followed by degradation tests under hydrolytic conditions was studied. The results showed that presence of ZnO significantly decreases thermal and mechanical stability. The nanofillers with the higher hydrophilic character are responsible for the fastest degradation of the PCL matrix. All films possessed high antimicrobial efficiency in long time intervals, hence, these nanocomposites open new avenues for the possible application of such materials for the delivery of drugs with a long-term effect.
Enhanced Tumor Targeting of Radiolabeled Mouse/Human Chimeric Anti-Tn Antibody in Losartan-Treated Mice Bearing Tn-Expressing Lung Tumors
Authors: Tassano Marcos , Camacho Ximena , Freire Teresa , Perroni Carolina , Costa Valeria da , Cabrera Mirel , García Maria Fernanda , Fernandez Marcelo , Gambini Juan Pablo , Cabral Pablo , Osinaga Eduardo 
Published: July 2023

Abstract

ChiTn, a mouse/human chimeric anti-Tn monoclonal antibody, was radiolabeled with iodine-131 (131I) and technetium-99m (99mTc) to assess its biodistribution and internalization in Tn-expressing (Tn+) and wild-type (Tn-) LL/2 lung cancer cells. Selective accumulation and gradual internalization of ChiTn were observed in Tn + cells. Biodistribution in mice with both Tn + or Tn- lung tumors indicated that the uptake of radiolabeled ChiTn within tumors increased over time. Dual-labeling experiments with 99mTc and 131I showed different biodistribution patterns, with 99mTc exhibiting higher values in the liver, spleen, and kidneys, while 131I showed higher uptake in the thyroid and stomach. However, tumor uptake did not significantly differ between Tn + and Tn- tumors. To improve tumor targeting, Losartan, an antihypertensive drug known to enhance tumor perfusion and drug delivery, was investigated. Biodistribution studies in Losartan-treated mice revealed significantly higher radiolabeled ChiTn uptake in Tn + tumors. No significant changes were observed in the uptake of the control molecule IgG-HYNIC-99mTc. These findings demonstrate the enhanced tumor targeting of radiolabeled ChiTn in Losartan-treated mice with Tn-expressing lung tumors. They highlight the potential of ChiTn as a theranostic agent for cancer treatment and emphasize the importance of Losartan as an adjunctive treatment to improve tumor perfusion and drug delivery.
Nurse contact in patients with home telemetry and association with 30-day hospital readmissions: Subgroup analysis of a randomized controlled trial
Authors: Dawson Nancy L. , Coombs Shannon S. , Haga Claire B. , Hedges Mary S. , Prier Cara C. , Walker Ashley L. , Ball Colleen , Yin Mingyuan , McManus Melinda S. , Tolaymat Leila M. 
Published: July 2023

Abstract
Background: Home telemonitoring has been shown to reduce 30-day readmissions patients at high risk for return to the hospital. The reason for this remains unclear. The aim of this study was to explore the association of nurse contact with 30-day hospital readmission in these high risk patients.
Methods: This study was a subgroup analysis from a prior randomized control comparing home telemonitoring for readmission for 30 days to usual care at discharge. Patients randomized to the home telemonitoring who had vital signs outside a preset range, triggered an alert flag for the monitoring nurse, which generated a contact to the patient. We compared patients who had at least one nurse contact to those who had none to see if the contact reduced the rate of readmissions in patients being monitored.
Results: Of 449 patients, 292 (65.0%) received 1 or more telemonitoring flags. Single variable and multivariable logistic regression models exploring the association of flag type with hospital 30-day readmission did not find any statistically significant associations of telemonitoring flags with hospital 30-day readmission (all unadjusted P≥0.13, all adjusted P≥0.18).
Conclusion: While post-hospitalization home telemetry has been shown to reduce 30-day readmission, our subset analysis did not show that the nurse contact was the factor that reduced readmission in these patients.
Trial registration: ClinicalTrials.gov identifier: NCT02136186, registration date May 12, 2014.
Optimal Routing and Charging Strategy of Electric Vehicles Based on Traffic Flow Prediction
Authors: Wang Yang , Li Bin , Zhao Zhenghui , Bao Jinhao , Wang Xianan 
Published: July 2023

Abstract
With the increasing number of electric vehicles (EVs) in recent years, road congestion is becoming a common phenomenon, which not only prolongs travel time but also causes anxiety for EV users. Therefore, this paper proposes a time-varying shortest path search method for traffic flow (TF) and establishes an EV route planning model based on this method to plan the optimal path for users. Firstly, a convolutional neural network (CNN) is used to predict TF and a new queuing model is established to calculate the charging queuing time. Then, a path planning model considering mid-way charging is established based on the predicted TF data and charging queuing model. Finally, the performance of the proposed method is tested using road network maps of different scales, and a case study on the optimal path of EV with mid-way charging under the minimum objective function is conducted based on a real traffic network. The results show that the proposed time-varying shortest path search method under the TF network can quickly calculate the optimal path and has great potential for solving practical problems.
A Study on Analysis of Functional Outcome of Percutaneous Release in Trigger Finger Under Ultrasound Guidance -A Novel Technique – At a Tertiary Care Hospital (Prospective Study)
Authors: .S Chandan.S CHANDAN , BASHA AM ILIAS BASHA AM ILIAS 
Published: July 2023

Abstract
BACKGROUND: Trigger finger is a condition that causes painful catching or popping of the involved flexor tendon as the patient flexes and extends the fingers. This condition is also known as “stenosing tenosynovitis.” Trigger finger is one of the most common pathologic conditions in hand surgery, with incidence rates of 2.2% throughout life time in the non-diabetic population more than 30 years and 10% in the diabetes mellitus populations.
MATERIAL AND METHODS: This is a prospective study of 60 cases of trigger finger who attended outpatient department of Kurnool medical college who were treated with percutaneous release of trigger finger under ultrasound guidance between November 2021 to January 2023.
RESULTS:Out of 60 patients, among the age group of 30-80 mean age was 62.33 years. Thirty eight (68.3%) were Male and twenty two (36.6%) were females. Thirty two (53.3%) were right side and twenty eight (46.6%) were left sided. There were eighteen (30%) thumbs, six (10%) index finger, two (3.3%) middle finger and thirty four(56.6%) ring fingers affected. Forty eight (80%) had Froimson grade 2 and twelve (20%) grade 3 cases. In our study mean preoperative DASH score was 24.99 and postoperative mean DASH score was 3.99. According to QUINNELLS grading 58 (96.66%) had excellent and 2 patients had good outcome and none of the patients had poor outcome in our study.
CONCLUSION: Percutaneous release of first annular pulley under ultrasound guidance (A1 pulley) is a safe, pain free, effective and outpatient procedure for patients with Trigger finger. It is a better alternative to open surgical procedure and can be considered as primary definitive treatment option for trigger finger.
Hyperspectral Image Classification Based on 3D-2D Hybrid Convolution and Graph Attention Mechanism
Authors: Zhang Hui , Tu Kaiping , Lv Huanhuan , Wang Ruiqin 
Published: July 2023

Abstract
Convolutional neural networks and graph convolutional neural networks are two classical deep learning models that have been widely used in hyperspectral image classification tasks with remarkable achievements. However, hyperspectral image classification models based on graph convolutional neural networks using only shallow spectral or spatial features are insufficient to provide reliable similarity measures for constructing graph structures, limiting their classification performance. To address this problem, we propose a hyperspectral image classification model combining 3D-2D hybrid convolution and a graph attention mechanism. First, a 3D-2D hybrid convolutional network is constructed and used to rapidly extract deep features that express spatial and spectral associations. Then, the graph is built based on deep spatial-spectral features to enhance the feature representation of the graph. Finally, a network of graph attention mechanisms is adopted to learn long-range spatial connections and to classify them using the extracted spatial features. The experimental results on two datasets, Indian Pine and the University of Pavia, show that the proposed method can achieve higher classification accuracy compared with other advanced methods.
Orbital Dynamics of Smart Dust with Poynting-Robertson and Solar Wind Drag
Authors: Vadlamani Vinayak , Gurfil Pini 
Published: July 2023

Abstract
Smart dust devices are tiny systems-on-a-chip platforms capable of sensing, storing and transmitting data wirelessly as part of a large network with distributed capabilities. Previous works investigated the long-term orbital evolution of smart dust in space by studying the combined effect of gravitational perturbations, solar radiation pressure (SRP), and atmospheric drag. In the current work, the problem of finding long-term orbital equilibria conditions for smart dust is recast and extended to include Poynting-Robertson and Solar Wind (PRSW) drag. By including the PRSW effects and defining new equilibrium conditions on the orbital orientation, some additional partial equilibrium solutions are found. Moreover, it is shown that even though PRSW is not dominant compared to SRP or $J_2$, it still influences the evolution of the relative Sun-orbit orientation. For orbits with higher initial perigee altitudes, where drag and $J_2$ effects subside, it is shown that PRSW influences long-term orbital behaviour, and should be considered in the orbit design scheme of smart dust devices.
Exploring the Complex Landscape of Electric Vehicle Adoption: Understanding Incentives and Overcoming Barriers for Sustainable Transportation in the US
Authors: Javadnejad Farshid , Jahanbakh Mohammad , Pinto Cesar Ariel , Saeidi Azita 
Published: July 2023

Abstract
The adoption of electric vehicles (EVs) is influenced by a range of incentives and barriers. EVs offer benefits such as reduced emissions and lower costs but face challenges in gaining widespread acceptance. Government subsidies, tax credits, and EV charging infrastructure have played a pivotal role in driving EV adoption, making them more financially attractive and convenient. However, barriers such as high upfront costs, limited driving range, insufficient charging infrastructure, and consumer concerns about battery life and availability have hindered broader uptake. This study presents a novel approach that considers both incentives and barriers to summarize the factors influencing EV development in the US. Through a comprehensive literature review, we explore the various barriers and incentives that affect EV deployment. Using an advanced fishbone diagram, we categorize the factors into economic and market, technical, policy, and social categories, providing a better understanding of their interrelationships. We discuss critical incentives and barriers within each category, offering a detailed analysis of their impact on EV adoption. Additionally, we present the results of a quantitative analysis of selected factors by examining their correlations with EV sales. This research provides a comprehensive understanding of the incentives and barriers to EV development in the US, assisting policymakers and stakeholders in developing effective strategies and initiatives for promoting EV adoption and achieving a cleaner and more sustainable future.
Web-Based Survey Piloting Process as a Model for Developing and Testing Past Contraceptive Use and Pregnancy History: Cystic Fibrosis Case Study
Authors: Godfrey Emily M , Schwartz Malaika  R , Stukovsky Karen D Hinckley , Woodward Danielle , Magaret Amalia S , Aitken Moira L 
Published: July 2023

Background
Individuals with complex, chronic diseases are now living longer, making reproductive health an important topic to address in the health care setting. Self-respondent surveys are a feasible way to collect past contraceptive use and pregnancy history to assess contraceptive safety and effectiveness. Because sensitive topics, such as contraception and pregnancy outcomes, can vary across social groups or cultures, piloting questions and evaluating survey administration procedures in the target population are necessary for precise and reliable responses before wide distribution.

Objective
This study aimed to develop a precise and reliable survey instrument and related procedures among individuals with cystic fibrosis regarding contraceptive use and obstetrical history.

Methods
We piloted and tested web-based questions related to contraceptive use and pregnancy history among 50 participants with and those without cystic fibrosis aged 18 to 45 years using a 3-tier process. Findings from each tier informed changes to the questionnaire before testing in the subsequent tier. Tier 1 used cognitive pretesting to assess question understanding and the need for memory prompts. In tier 2, we used test-retest self- and interviewer-administered approaches to assess question reliability, evaluate response missingness, and determine confidence between 2 types of survey administration approaches. In tier 3, we tested the questionnaire for clarity, time to complete, and whether additional prompts were necessary.

Results
In tier 1, respondents suggested improvements to the web-based survey questions and to the written and visual prompts for better recall regarding past contraceptive use. In tier 2, the test-retest reliability between self- and interviewer-administrative procedures of “ever use” contraceptive method questions was similar, with percent absolute agreement ranging between 84% and 100%. When the survey was self-administered, the percentage of missing responses was higher and respondent confidence about month and year when contraceptive methods were used was lower. Most respondents reported that they preferred the self-administered survey because it was more convenient and faster to complete.

Conclusions
Our 3-tier process to pilot web-based survey questions related to contraceptive and obstetrical history in our complex disease population helped us tailor content and format questions before wide dissemination to our target population. Results from this pilot study informed the subsequent larger study design to include a 10% respondent test-retest self- and interviewer-administered quality control component to better inform imputation procedures of missing data.
Innovative Management Strategies for the Rule of Law of Cross-border Mobile Population Based on Information Fusion Technology
Authors: Wu Lixia 
Published: July 2023

Abstract
In the context of continuous globalization, how to put the cross-border mobile population under the rule of law for innovative management, it is a much-needed pathway to find in today’s society. This paper proposes to improve the legislation, establish a data platform, management strategies for creating bilateral educational cooperation models. Information fusion using maximum likelihood and least squares methods, collating and analyzing data from multiple sources, innovative governance strategies for cross-border mobile populations. To improve the social integration of cross-border mobile populations at the level of social integration, social recognition, etc. Safeguard social stability at the border. For example, the creation of a bilateral educational cooperation model, it has been proved by experimental results that education helps to improve the local living conditions of cross-border mobile populations. If more education could be made available to the mobile, would allow for broader career options for cross-border mobile populations, increase their social inclusion level by 9 percent, and increase their intention to stay locally by 0.9 percentage points. Provides a good internal environment for its integration, enhancing the stability of cross-border mobile population migration, it is of great significance to the social stability of the border area.