bluuebunny/crossref_metadata_2025_split huggingface dataset:
VISCOSITY AND PARTICLE SIZE DISTRIBUTION OF CONCENTRATED APPLE JUICE PRODUCED BY SPINNING DISC REACTOR (SDR)
Authors: Safriani Novi 
Published: May 2023

This research explored the potential use of the spinning disc reactor (SDR), a novel processing technique used for the production of concentrated apple juice. The apple juice was passed over the SDR disc spinning at 2000 rpm, heated at various temperatures (90 °C, 100 °C, 110 °C, and 120 °C), and at a flow rate of 7 ml/s. The effect of SDR-processing on viscosity and particle size of the apple juice concentration, was investigated. The SDR-concentrated apple juice exhibits narrow particle size distribution (average particle size in the range of d32 = 0.1-0.2 µm and d43 = 4-12 µm) and shear-thinning behaviour in the range of shear rates from 0.1 – 200 s-1, in which the viscosity decreases with increasing the shear rate. The reconstituted samples show similar viscosity with its original counterpart. The increase of the processing temperature allows a reduction in the processing time. The results reveal that the SDR is capable of producing the concentrated apple juice.
Pengaruh Suplementasi Tepung Terigu terhadap Pertumbuhan dan Laju Pengasaman Probiotik Lactobacillus acidophilus
Authors: Mariana Elmy , Susanti Hilda 
Published: May 2023

This study aimed to determine the effect of the addition of wheat flour as a potential prebiotic on growth and acidification rate of probiotic Lactobacillus acidophilus (L. acidophilus) in fermented milk. The study was conducted by adding the flour with concentrations 1, 3 and 5% in the fermentation medium with 15% skim milk. Observed growth parameters including the total number of probiotic bacteria, decreasing pH and increasing acidity during the fermentation process. The results showed that the addition of wheat flour speed up the fermentation time, accelerate the process of decline in pH, increasing the acidity and increase the total number of probiotic bacteria.This study shows that wheat flour supplemented in fermented milk could enhance the growth characteristics of probiotics L. acidophilus. Keywords: probiotics, L. acidophilus, growth, wheat flour
Sucrose, Reducing Sugars,and Carotenoid Content of Aceh Besar Sweet Potato Cultivars (Ipomoea batatas L)
Authors: Zaidiyah Zaidiyah 
Published: May 2023

Sweet potato is considered as an important food crop and it is known as one of the most productive carbohydrate-producing crop. This crop requires less inputs and water in comparison to rice, corn, or potato. Its wide adaptation to various agro ecological conditions has made sweet potato as a promising crop for saving life particularly during food (rice) shortage. The crop contained higher vitamin (A) and minerals that could help women and children aged below five preventing certain diseases. However, the nutritional value of sweet potato is various from one cultivar to another. It was assumed that geographical and environmental factors would influence the nutritional value of the tubers. Therefore, the following study was investigating the nutritional value of local cultivars in Aceh Besar District. Total carotenoid content of sweet potato varied from 1.86to 3.06 mg 100g-1 DM. The highest carotenoid was recorded by cv. Keupila from Saree Sub-district.
UM ESTUDO SOBRE A AGRICULTURA FAMILIAR CAMPONESA SOB A ABORDAGEM SISTÊMICA NO DISTRITO DE SANTA TERESINHA, PALMEIRA DAS MISSÕES-RS / STUDY ON FAMILY AGRICULTURE UNDER THE SYSTEMATIC APPROACH IN THE DISTRICT OF SANTA TERESINHA, PALMEIRA DAS MISSÕES-RS
Authors: Fernandes Sibeli 
Published: May 2023

Apesar das diversas mudanças estruturais que ocorreram na agricultura, durante os últimos tempos, permanece significativa importância da categoria social da agricultura familiar camponesa nas dinâmicas socioprodutivas presentes no campo. Neste artigo, são apresentados dados de campo preliminares, a fim de caracterizar o sistema da agricultura da agricultura familiar camponesa no espaço rural do distrito de Santa Teresinha, no município de Palmeira das Missões/RS. Como opção metodológica foi adotada para este estudo a análise dos elementos físicos (solo, vegetação e sistema hídrico), e as características do sistema da agricultura local (sociais, técnicas e produtivas). A análise integrada permitirá compreender a organização socioespacial da agricultura familiar camponesa no distrito de Santa Teresinha e, a partir daí, elaborar diagnósticos/prognósticos que possam subsidiar ações voltadas ao planejamento rural visando o desenvolvimento do municipio.
PLANEJAMENTO URBANO E RISCOS: A FUNÇÃO SOCIAL DA PROPRIEDADE NOS PLANOS DIRETORES DE CINCO MUNICÍPIOS DA REGIÃO METROPOLITANA DE BELÉM/PA / URBAN PLANNING AND RISKS: SOCIAL FUNCTION OF PROPERTY IN FIVE MUNICIPALITIES’ MASTER PLANS OF THE METROPOLITAN...
Authors: Moraes de Outeiro Gabriel , Colman de Azevedo Junior Wladimir 
Published: May 2023

É notável a substituição das certezas que sustentavam a sociedade industrial por incertezas e riscos, herdados do processo de industrialização. Assim, a produção da riqueza é acompanhada por riscos, que imprimem no espaço um sistema excludente, em prejuízo das camadas da população economicamente desfavorecidas. Por isso, é necessário adotar um planejamento urbano que permita uma justa distribuição do espaço urbano. O presente trabalho tem por objetivo identificar a existência de elementos que possibilitam a democratização do acesso ao solo urbano, no conceito da Função Social da Propriedade presente nos Planos Diretores dos municípios paraenses de Ananindeua, Belém, Benevides, Castanhal e Santa Bárbara do Pará. Utilizou-se de uma abordagem de natureza teórica e, como procedimento metodológico, de pesquisa bibliográfica, documental e descritiva, que usou como fonte primária os Planos Diretores daqueles municípios. Como resultado tem-se os casos opostos de Castanhal e de Belém, em que o Plano do primeiro não define a Função Social da Propriedade e também não apresenta os coeficientes mínimos, enquanto o Plano de Belém pode ser considerado de maior viabilidade por dispor dos dois elementos. Os demais municípios apresentam definição genérica ou ausência dos coeficientes.Palavras-chave: Função Social da Propriedade; Plano Diretor Municipal; Planejamento Urbano.
HIDRELÉTRICAS NA AMAZÔNIA: O CASO DE CACHOEIRA PORTEIRA, ORIXIMINÁ-PA
Authors: Reale Fátima Cristina Guerreiro , Cavalcante Maria Madalena De Aguiar 
Published: May 2023

A Amazônia tem experienciado pressões socioambientais decorrentes da matriz energética predominante no Brasil. A necessidade de geração de energia e o volume hídrico da Amazônia propiciou decisões, ainda no período do governo militar, para o planejamento e a construção de hidrelétricas na região, fato evidenciado no caso do projeto hidrelétrico de Cachoeira Porteira, local homônimo a cachoeira onde vivem populações tradicionais e lidam com a possibilidade da construção de hidrelétrica. Nesse sentido, o objetivo do artigo consiste em analisar a dinâmica de planejamento e instalação da hidrelétrica em Cachoeira Porteira, considerando a pressão nas áreas de castanheiras (Bertholletia excelsa) e nas populações extrativistas, no município de Oriximiná, Pará, ao norte do Brasil. A metodologia utilizada é de carácter qualitativo, a partir de análise documental que retrata o período entre 1950 a 2014, bem como, entrevistas e rodadas de conversas para obtenção de relatos sobre a perspectiva de desapropriação da área em que a hidrelétrica seria instalada. Os resultados demonstraram que as populações tradicionais, desde a primeira proposição do projeto, vivenciaram constantes períodos de angústia, dado às recorrentes possibilidades de implantação da hidrelétrica de Cachoeira Porteira, sobretudo os extrativistas obrigados a migrar para outras áreas, desarticulando a cadeia produtiva da castanha, sem indenizações em suas perdas, econômicas e socioculturais. A dinâmica territorial demonstrada pelas populações tradicionais, mesmo anterior a instalação da usina, pode ser observada e analisada enquanto impacto especulativo, cuja característica consiste nos rearranjos e efeitos anteriores a sua materialização, contudo, já apresenta impactos de diversas ordens e permite vislumbrar que, diante do plano de expansão energética, tais eventos para a Amazônia e outras áreas têm sido tensionados como a da Cachoeira Porteira que, desde o período militar prevê o projeto de implantação da usina e até os dias atuais permanece nos planos energéticos enquanto possiblidade, gerando incertezas e desarticulação de toda a dinâmica local.
Message from the editor in Chief
Authors: YILDIZ Ezgi Pelin 
Published: May 2023

The year 2022 promises many exciting developments for the Global Journal of Information Technology: Emerging Technologies (GJIT). In addition, every year, the number of citations continues to rise strongly in proportion to the increase in the number of articles published. In this respect, first of all, we would like to thank all our authors who have contributed to the success of our journal. While reviewing our new issue, we saw articles from different authors from different countries: Cyprus, Jordan, Iran etc.
The multiculturalism policy followed in our globally-focused journal makes us happy with every new issue. We examine the following research areas in the current issue; The topics of “Creating a Mobile Application for Online Shopping that has all the Features Required for the Process”, “Requirements For The Use Of E-Learning In University Education (Theoretical Study)”, “Attitudes Of Physical Education Teachers InJordan Towards The Use Of The Internet In The Educational Process”, “An Inquest into the Degree of M.A. Translation Students’ Familiarity with Computer-Assisted Translation (CAT) Tools”. We will continue to contribute to the literature within the scope of Educational Technologies with our strong team. Thanks to all our authors the contributors to this issue.
Hope to see you in our new issue. Asist. Prof. Dr. Ezgi Pelin YILDIZ
Global Journal of Information Technology: Emerging Technologies Chef Editor
A Black Queer Phenomenology of Space in James Baldwin’s Giovanni’s Room
Authors: Darjeun Meadows Lucien 
Published: May 2023

In Giovanni’s Room (1956), James Baldwin emphasises the Black queer space of architecture, particularly of lines, walls, and wallpaper. In particular, by using walls to highlight the existence of the poché, or in-between architectural pocket space, Baldwin generates an inside/outside space that facilitates a slippage and reclamation of subjectivity for his queer characters.Throughout this novel, the characters seek shelter and are described as houses and walls themselves even as they are un-housed in spaces which, from an apartment building to the human body, are always permeable and temporary. Each wall of Baldwin’s novel is, like Black space and queer space, a site of tension and entanglement. These walls are complicated by Giovanni’s violent efforts to expand the architectural and symbolic space of his room. He takes a hammer to the walls not to escape into another apartment on the other side of the walls but, rather, to open the poché between walls.The poché is a liminal and undefined inside/outside space (even on architectural blueprints, when/if it appears). Baldwin’s use of the poché in this novel disrupts white and (hetero)normative expectations of space and classification, makes visible hidden histories, resists stability, and promotes inclusive assemblages.
Origin Recognition Complex Subunit 1(ORC1) is a potential biomarker and therapeutic target in cancer
Authors: Wu Linling , Chen Hui , Yang Chao 
Published: May 2023

Abstract
Background
The origin recognition complex 1 (ORC1) is a large subunit of the origin recognition complex and acts as the master subunit of the precoding complex.
Objective
To explore potential function and clinical significance of ORC1 in cancers.
Methods
The expression level of ORC1 in different types of tumor tissues and matched normal tissues were detected by The Cancer Genome Atlas (TCGA) and validated by datasets from the gene expression omnibus (GEO) database. The association between ORC1 expression and infiltration levels of immune cell was analyzed. ORC1 and its co-expression genes were subjected to enrichment analysis to explore potential mechanisms in cancers, and the protein-protein interaction (PPI) network was constructed. Finally, the expression of ORC1 in tumor tissue and adjacent tissue was verified by immunohistochemistry (IHC).
Results
ORC1 was highly expressed in the majority of tumors, and the expression level of ORC1 was associated with the pathological stages of ACC, LUAD, OV and SKCM. ORC1 was closely related with poor prognosis in ACC, LIHC, PAAD, READ and THCA. ORC1 in ACC and KICH was positively correlated with the infiltration level of immune cells while it was negatively correlated with the infiltration level of immune cells in THYM. Co-expression network analysis showed that CDCA3, GSG2, KIF2C, NCAPH and PLK1 were positively correlated with ORC1 in cancer, and enrichment analysis showed a correlation with cytosol, ATP binding and cell division. The expression of ORC1 in UCEC and KICH was higher than that in the adjacent tissues.
Conclusion
ORC1 over-expressed in most tumors and could be severed as a novel biomarker for diagnosis. This study revealed that ORC1 might inhibit tumor immunity and might be a potential therapeutic target in cancers.
Discovery of a selective YTHDC1 inhibitor that targets acute myeloid leukemia
Authors: Yang Shengyong , Zhang Hailin , Li Yueshan , Wang Falu , Lin Guifeng , Niu Ting , Li He , Yi Yuyao , Zhou Hui , Yang Ruicheng , Yao Rui , Zhou Pei , Li Yueyue , Wu Mengdan , Chen Ming-Xin , Xu Haixing , You Jing , Liao Yi , Yang Chenlu , Zhao Ailin , Chen Chong , Li Linli , Wei Yuquan 
Published: May 2023

Abstract
N6-methyladenosine (m6A) is the most prevalent modification of eukaryotic RNA, which is recognized by m6A-binding proteins (“readers”) and thereby mediates multiple biological processes. Dysregulation of the m6A readers has been linked to various pathologies, but the therapeutic potential of small molecule inhibitors targeting the m6A readers is unknown. Here we report the identification and characterization of a highly potent and selective first-in-class inhibitor (YL-5092) of YT521-B homology (YTH) domain-containing protein 1 (YTHDC1), which is a nuclear RNA m6A reader and plays essential roles in the pathological process of acute myeloid leukemia (AML). The crystal structure of YTHDC1 in complex with YL-5092 well explained its potency and selectivity. YL-5092 treatment substantially suppressed the proliferation and induced the differentiation and apoptosis of AML cells. It also efficiently inhibited the colony-forming ability of CD34+ AML stem cells, but had no effect on normal hematopoietic stem cells and early progenitors (Lin− Sca1+ Kit+). Moreover, YL-5092 treatment impaired leukemogenesis and improved the animal survival rate in mouse AML xenograft models. Collectively, this research reveals a therapeutic potential of YTHDC1 inhibitors against AML, and provides proof of concept that targeting m6A readers represents a promising strategy for cancer treatment.
Safety Accident Analysis of Power Transmission and Substation Projects Based on Association Rule Mining
Authors: Liu Wanfang , Wang Xueyang , Ye Penghao , Jiang Luping , Feng Ruixiang 
Published: May 2023

Abstract
To achieve the sustainable development goals (SDGs) of power transmission and substation project construction, statistical analysis was used to provide an outline of safety accidents, the 4M1E method was applied for sorting out and analyzing the risk factors, and the Apriori algorithm was carried out for exploring the intrinsic interaction among risk factors based on association rule mining. The results showed that the safety accidents that happen in the construction of power transmission and substation projects were not much frequent, but deadly; and the process of foundation construction and high fall was the most accident-prone process and injury type respectively. In addition, human behaviors were the foremost factors leading to accidents, and there was a strong correlation among the risk factors of low project management level, lack of safety awareness and poor risk identification ability. For improving the security situation, measures should be taken for controlling human factors, performing flexible management, and strengthening safety training. In further research, more detailed and diversified accident reports and case data should be analyzed, and more consideration should be put on the weighted risk factor analysis in order to obtain more comprehensive and objective safety accident analysis results for power transmission and substation projects.
Effects of Pichia kudriavzevii on development, larval mortality and adult fecundity of Zaprionus indianus (Diptera: Drosophilidae) at different temperatures.
Authors: Sharma Aanchal , Ramniwas Seema 
Published: May 2023

Abstract

Host–pathogens interactions are sensitive to changes in temperature. Increase in temperature significantly influences the distribution of fruit flies. African fig fly, known as Zaprionus indianus (Gupta) (Diptera: Drosophilidae) is one of the invasive, secondary insect pests of fruits. The current article explores the effect of temperature and fungal infection on Z. indianus life history traits. Development of Z. indianus was observed on locally isolated fungus Pichia kudriavzevii (Boidin, Pignal and Besson, 1965) (Saccharomycetales: Pichiaceae) treated and untreated medium. Pre- adult and adult life stages of treated and untreated individuals at different temperatures showed significant difference in trait values and mortality. At extreme temperatures (i.e. 17◦C and 31◦C) the life history traits (egg hatchability, viability, adult emergence, pupation rate and fecundity) in fungi- treated food showed significant reduction in trait values except in development period (egg to adult stage) at 17◦C. High temperatures (28◦C and 31◦C) favour shorter fungal development period but that of Z. indianus was considerably delayed by 5 days at all tested temperatures in treated medium. The current work illustrates the consequences of temperature and fungal infection on the developmental stages and physiological traits of Z. indianus. The combination of the biotic and abiotic factors aids in understanding of the response of pest species of Drosophila to differential temperature ranges and fungal infection; hence, the present study could assist in predicting the driving ecological factors that mediate the containment of Z. indianus, an invasive secondary pest of India.
Type of article:Quality Communication Can Improve Patient-Centred Health Outcomes Among Older Patients: A Systematic Review
Authors: Sharkiya Samer 
Published: May 2023

Abstract
Background: Effective communication is a cornerstone of quality healthcare. Communication helps providers bond with patients, forming therapeutic relationships that benefit patient-centred outcomes. The information exchanged between the provider and patient can help in medical decision-making, such as better self-management. This systematic review investigated the effects of quality and effective communication on patient-centred outcomes among older patients.
Methods: Google Scholar, PubMed, Scopus, CINAHL, and PsycINFO were searched using keywords like "effective communication," "elderly," and "well-being." Studies published between 2000 and 2023 describing or investigating communication strategies between older patients (65 years and above) and providers in various healthcare settings were considered for selection. The quality of selected studies was assessed using the GRADE Tool.
Results: The search strategy yielded seven studies. Four studies were qualitative (one phenomenological study, one ethnography, and two grounded theory studies), one was a cross-sectional observational study, one was an experimental study, and the final was a quantitative study (unclear design). The studies investigated the effects of verbal and nonverbal communication strategies between patients and providers on various patient-centred outcomes, such as patient satisfaction, quality of care, quality of life, and physical and mental health. All the studies reported that various verbal and non-verbal communication strategies positively impacted all patient-centred outcomes.
Conclusion: Although the selected studies supported the positive impact of effective communication with older adults on patient-centred outcomes, they had various methodological setbacks that need to be bridged in the future. Future studies should utilize experimental approaches, generalizable samples, and specific effect size estimates.
Abnormal activation of the Wnt3a/β-catenin signaling pathway promotes the expression of TBX3 and the EMT pathway to mediate the occurrence of adenomyosis
Authors: Li Mengqi , Li Ting , Jin Tingting , Chen Yi , Cheng Lan , Liang Qiheng , Yan Simiao , Li Tingting , Chen Wanqun , Ran Qingzhen 
Published: May 2023

Abstract
Background TBX3 is a transcription factor that can regulate cell proliferation, apoptosis, invasion, and migration in different tumor cells; however, its role in adenomyosis (ADM) has not been previously studied. Some of ADM’s pathophysiological characteristics are similar to those of malignant tumors (e.g., abnormal proliferation, migration, and invasion).Methods and results we hypothesized that TBX3 might have a role in ADM. We used tamoxifen-induced ICR mice to establish ADM disease model. The study procedure included western blotting and immunohistochemistry to analyze protein levels; additionally, we used intraperitoneal injection of Wnt/β-catenin pathway inhibitor XAV-939 to study the relationship between TBX3 and Wnt/β-catenin pathway as well as PCNA and TUNEL to detect cell proliferation and apoptosis, respectively. TBX3 overexpression and epithelial-to-mesenchymal transition (EMT) in ADM mice was found to be associated with activation of the Wnt3a/β-catenin pathway. Treatment with XAV-939 in ADM mice led to the inhibition of both TBX3 and EMT; moreover, abnormal cell proliferation was suppressed, the depth of invasion of endometrium cells was limited and the expression of ERα was suppressed. Thus, the use of XAV-939 effectively inhibited further invasion of endometrial cells.Conclusion These findings suggest that TBX3 may play an important role in the development of ADM. The expression of TBX3 in ADM was regulated by the Wnt3a/β-catenin pathway. The activation of the Wnt3a/β-catenin pathway in ADM promoted TBX3 and ERα expression and induced the occurrence of EMT, thus promoting cell proliferation and inhibiting apoptosis, ultimately accelerating the development of ADM. The study provides a reference for the diagnosis of ADM