bluuebunny/crossref_metadata_2025_split huggingface dataset:
The trace-element compositions of amphibole, magnetite and ilmenite as potential exploration guides to metamorphosed Proterozoic Cu–Zn±Pb±Au±Ag volcanogenic massive sulfide deposits in Colorado, USA
Authors: Spry Paul G. , Berke Edward H. , Layton-Matthews Dan , Voinot Alexandre , Heimann Adriana , Teale Graham S. , von der Handt Anette 
Published: September 2023

AbstractOrthoamphibole, clinoamphibole and magnetite are common minerals in altered rocks associated spatially with Palaeoproterozoic volcanogenic massive sulfide (VMS) deposits in Colorado, USA and metamorphosed to the amphibolite facies. These altered rocks are dominated by the assemblage orthoamphibole (anthophyllite/gedrite)–cordierite–magnetite±gahnite±sulfides. Magnetite also occurs in granitoids, banded iron formations, quartz garnetite, and in metallic mineralisation consisting of semi-massive pyrite, pyrrhotite, chalcopyrite, and sphalerite with subordinate galena, gahnite and magnetite; amphibole also occurs in amphibolite. The precursor to the anthophyllite/gedrite–cordierite assemblages was probably the assemblage quartz–chlorite formed from hydrothermal ore-bearing fluids (~250° to 400°C) associated with the formation of metallic minerals in the massive sulfide deposits.Element–element variation diagrams for amphibole, magnetite and ilmenite based on LA-ICP-MS data and Principal Component Analysis (PCA) for orthoamphiboles and magnetite show a broad range of compositions which are primarily dependent upon the nature of the host rock associated spatially with the deposits. Although discrimination plots of Al/(Zn+Ca) vs Cu/(Si+Ca) and Sn/Ga vs Al/Co for magnetite do not indicate a VMS origin, the concentration of Al+Mn together with Ti+V and Sn vs Ti support a hydrothermal rather than a magmatic origin for magnetite. Principal Component Analyses also show that magnetite and orthoamphibole in metamorphosed altered rocks and sulfide zones have distinctive eigenvalues that allow them to be used as prospective pathfinders for VMS deposits in Colorado. This, in conjunction with the contents of Zn and Al in magnetite, Zn and Pb in amphibole, ilmenite and magnetite, the Cu content of orthoamphibole and ilmenite, and possibly the Ga and Sn concentrations of magnetite constitute effective exploration vectors.
Genome-wide analysis of the P450 gene family in tea plant (Camellia sinensis) reveals functional diversity in abiotic stress
Authors: Shen Chuan , Li Xia 
Published: September 2023

Abstract
Background
Cytochrome P450 (Cytochrome P450s) genes are involved in the catalysis of various reactions, including growth, development, and secondary metabolite biosynthetic pathways. However, little is known about the characteristics and functions of the P450 gene family in Camellia sinensis (C. sinensis).

Results
To reveal the mechanisms of tea plant P450s coping with abiotic stresses, analyses of the tea plant P450 gene family were conducted using bioinformatics-based methods. In total, 273 putative P450 genes were identified from the genome database of C. sinensis. The results showed that P450s were well-balanced across the chromosomes I to XV of entire genome, with amino acid lengths of 268–612 aa, molecular weights of 30.95–68.5 kDa, and isoelectric points of 4.93–10.17. Phylogenetic analysis divided CsP450s into 34 subfamilies, of which CYP71 was the most abundant. The predicted subcellular localization results showed that P450 was distributed in a variety of organelles, with chloroplasts, plasma membrane,,and cytoplasm localized more frequently. The promoter region of CsP450s contained various cis-acting elements related to phytohormones and stress responses. In addition, ten conserved motifs (Motif1-Motif10) were identified in the CsP450 family proteins, with 27 genes lacking introns and only one exon. The results of genome large segment duplication showed that there were 37 pairs of genes with tandem duplication. Interaction network analysis showed that CsP450 could interact with multiple types of target genes, and there are protein interactions within the family. Tissue expression analysis showed that P450 was highly expressed in roots and stems. Moreover, qPCR analysis of the relative expression level of the gene under drought and cold stress correlated with the sequencing results.

Conclusions
This study lays the foundation for resolving the classification and functional study of P450 family genes and provides a reference for the molecular breeding of C. sinensis.
Addressing cancer care inequities in sub-Saharan Africa: current challenges and proposed solutions
Authors: Omotoso Olabode , Teibo John Oluwafemi , Atiba Festus Adebayo , Oladimeji Tolulope , Paimo Oluwatomiwa Kehinde , Ataya Farid S. , Batiha Gaber El-Saber , Alexiou Athanasios 
Published: September 2023

Abstract
Introduction
Cancer is a significant public health challenge globally, with nearly 2000 lives lost daily in Africa alone. Without adequate measures, mortality rates are likely to increase. The major challenge for cancer care in Africa is equity and prioritization, as cancer is not receiving adequate attention from policy-makers and strategic stakeholders in the healthcare space. This neglect is affecting the three primary tiers of cancer care: prevention, diagnosis, and treatment/management. To promote cancer care equity, addressing issues of equity and prioritization is crucial to ensure that everyone has an equal chance at cancer prevention, early detection, and appropriate care and follow-up treatment.

Methodology
Using available literature, we provide an overview of the current state of cancer care in Africa and recommendations to close the gap.

Results
We highlight several factors that contribute to cancer care inequity in Africa, including inadequate funding for cancer research, poor cancer education or awareness, inadequate screening or diagnostic facilities, lack of a well-organized and effective cancer registry system and access to care, shortage of specialized medical staff, high costs for screening, vaccination, and treatment, lack of technical capacity, poor vaccination response, and/or late presentation of patients for cancer screening. We also provide recommendations to address some of these obstacles to achieving cancer care equity. Our recommendations are divided into national-level initiatives and capacity-based initiatives, including cancer health promotion and awareness by healthcare professionals during every hospital visit, encouraging screening and vaccine uptake, ensuring operational regional and national cancer registries, improving healthcare budgeting for staff, equipment, and facilities, building expertise through specialty training, funding for cancer research, providing insurance coverage for cancer care, and implementing mobile health technology for telemedicine diagnosis.

Conclusion
Addressing challenges to cancer equity holistically would improve the likelihood of longer survival for cancer patients, lower the risk factors for groups that are already at risk, and ensure equitable access to cancer care on the continent. This study identifies the existing stance that African nations have on equity in cancer care, outlines the current constraints, and provides suggestions that could make the biggest difference in attaining equity in cancer care.
Which surgical approach is more favorable for pheochromocytoma of different sizes (< 6 cm vs. ≥ 6 cm)? A single retrospective center experience
Authors: Wan Shun , Li Kunpeng , Wang Chenyang , Chen Siyu , Wang Huabin , Luo Yao , Li Xiaoran , Yang Li 
Published: September 2023

Abstract
Background
To compare the surgical effects of lateral transperitoneal approach (LTA) and posterior retroperitoneal approach (PRA) for pheochromocytoma of different sizes.

Methods
Data on patients with pheochromocytoma from 2014 to 2023 were collected from our hospital. According to different surgical approaches and tumor size, all patients were divided into four groups: tumor size < 6 cm for LTA and PRA and tumor size ≥ 6 cm for LTA and PRA. We compared these two surgical methods for pheochromocytoma of different sizes.

Results
A total of 118 patients with pheochromocytoma underwent successful laparoscopic surgery, including PRA group (n = 80) and LTA group (n = 38). In tumor size < 6 cm, the outcomes were no significant difference in LTA and PRA. In tumor size ≥ 6 cm, there was a significant difference in operation time (214.7 ± 18.9 vs. 154.3 ± 8.2, P = 0.007) and intraoperative blood loss (616.4 ± 181.3 vs. 201.4 ± 45.8, P = 0.037) between LTA and PRA.

Conclusion
LTA and PRA were performed safely with similar operative outcomes in patients with pheochromocytoma size < 6 cm. While both LTA and PRA were executed with a commendable safety profile and comparable operative results in patients afflicted by pheochromocytomas < 6 cm, the PRA technique distinctly showcased advantages when addressing large-scale pheochromocytomas (≥ 6 cm). Notably, this manifested in reduced operative time, diminished intraoperative blood loss, decreased hospitalization expenses, and a paucity of procedural complications.
Nonexistence of interior bubbling solutions for slightly supercritical elliptic problems
Authors: Ben Ayed Mohamed , El Mehdi Khalil 
Published: September 2023

AbstractIn this paper, we consider the Neumann elliptic problem $(\mathcal{P}_{\varepsilon})$
(

P
ε

)
: $-\Delta u +\mu u = u^{(({n+2})/({n-2}))+\varepsilon}$
−
Δ
u
+
μ
u
=

u

(
(
n
+
2
)
/
(
n
−
2
)
)
+
ε

, $u>0$
u
>
0
in Ω, ${\partial u}/{\partial \nu}=0$
∂
u
/
∂
ν
=
0
on ∂Ω, where Ω is a smooth bounded domain in $\mathbb{R}^{n}$

R
n

, $n\geq 4$
n
≥
4
, ε is a small positive real, and μ is a fixed positive number. We show that, in contrast with the three dimensional case, $(\mathcal{P}_{\varepsilon})$
(

P
ε

)
has no solution blowing up at only interior points as ε goes to zero. The proof strategy consists in testing the equation by appropriate vector fields and then using refined asymptotic estimates in the neighborhood of bubbles, we obtain equilibrium conditions satisfied by the concentration parameters. The careful analysis of these balancing conditions allows us to obtain our results.
Research progress on the role of extracellular vesicles in neurodegenerative diseases
Authors: Li Zhengzhe , Wang Xiaoling , Wang Xiaoxing , Yi Xiaomei , Wong Yin Kwan , Wu Jiyang , Xie Fangfang , Hu Die , Wang Qi , Wang Jigang , Zhong Tianyu 
Published: September 2023

AbstractNeurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, affect millions of people worldwide. Tremendous efforts have been put into disease-related research, but few breakthroughs have been made in diagnostic and therapeutic approaches. Extracellular vesicles (EVs) are heterogeneous cell-derived membrane structures that arise from the endosomal system or are directly separated from the plasma membrane. EVs contain many biomolecules, including proteins, nucleic acids, and lipids, which can be transferred between different cells, tissues, or organs, thereby regulating cross-organ communication between cells during normal and pathological processes. Recently, EVs have been shown to participate in various aspects of neurodegenerative diseases. Abnormal secretion and levels of EVs are closely related to the pathogenesis of neurodegenerative diseases and contribute to disease progression. Numerous studies have proposed EVs as therapeutic targets or biomarkers for neurodegenerative diseases. In this review, we summarize and discuss the advanced research progress on EVs in the pathological processes of several neurodegenerative diseases. Moreover, we outline the latest research on the roles of EVs in neurodegenerative diseases and their therapeutic potential for the diseases.
Perceived Social Support and Anxiety among Chronic Hepatitis-C Patients
Authors: Hafeez Muhammad , Hafeez Qurat Ul Ain , Siddiqi Fuad Ahmad 
Published: September 2023

Objective: To study the relationship of perceived social support (PSS) and anxiety among patients of Chronic Hepatitis C (CHC).
Methods: It is a cross sectional survey conducted from March 2021 to December 2021 in different hospitals of Islamabad and Rawalpindi. Sampling was done through purposive and snowball technique. Self-administered and standardized questionnaires were used. To analyze perceived social support and anxiety, perceived social support “scale” and Beck anxiety inventory were used in patients of Hepatitis C. Patients Polymerase Chain Reaction (PCR) positive HCV patients between the ages 31 to 50 years were included. Patients with comorbid conditions and other than 31 to 50 years of age were excluded from the study.
Results: Out of 250, males were 185(74%) and females 65(26%). Ages were between 31 to 50 years. PSS in both males and females was 49.8 and 49 (p=0.63%) with anxiety level 44.63 and 56.18 (p=0.00) respectively. There was no significant gender differences on PSS but women had significantly higher on anxiety (M = 56.18, SD = 11.36) with moderate effect size (>.05). PSS had significant negative correlation with anxiety (r = -.31, p < .05).
Conclusion: Anxiety is more common in females and perceived social support has negative correlation with anxiety in patients of Chronic Hepatitis C.
doi: https://doi.org/10.12669/pjms.39.6.7412
How to cite this: Hafeez M, Hafeez QA, Siddiqi FA. Perceived Social Support and Anxiety among Chronic Hepatitis-C Patients. Pak J Med Sci. 2023;39(6):---------. doi: https://doi.org/10.12669/pjms.39.6.7412
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
An initial experience of using dual energy contrast enhanced mammography at a tertiary care hospital in Pakistan
Authors: Zeeshan Sana , Shafqat Gulnaz , Ali Danish , Vohra Lubna 
Published: September 2023

Objective: Contrast enhanced mammography (CEM), a relatively new and promising modality, combines mammography (MMG) with an iodinated contrast material to illuminate neovascularity within the breast; analogous to magnetic resonance imaging (MRI). CEM improves the overall sensitivity of MMG; reduces the need for unnecessary biopsies and follow-up imaging and can be considered a reasonable substitute for MRI. In Pakistan, CEM was recently introduced and to assess its usability a study was conducted on five patients before making it available as a regular investigation.
Case presentations: Four out of the five patients had a clinical suspicion of malignancy with two patients having heterogeneously dense breasts and two with dense breasts. All enhancing lesions were concordant on biopsy and had similar corresponding findings on additional imaging such as ultrasound (US) and/or MRI. CEM in all four cases of biopsy proven malignancy facilitated surgical planning. The fifth patient underwent CEM for screening and was found to have no enhancing lesion.
Conclusion: In low-middle-income countries (LMICs) where breast MRI is not readily available and expensive for the populace, CEM can be a reliable alternative. The initial experience with CEM at our hospital shows better visualization of malignant lesions in dense and heterogeneously dense breasts with an easy-to-perform technique and a shorter imaging time while facilitating surgical decision-making in terms of breast conservation.
doi: https://doi.org/10.12669/pjms.39.6.7607
How to cite this: Zeeshan S, Shafqat G, Ali D, Vohra L. An initial experience of using dual energy contrast enhanced mammography at a tertiary care hospital in Pakistan. Pak J Med Sci. 2023;39(6):---------. doi: https://doi.org/10.12669/pjms.39.6.7607
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The cognitive remediation of attention in HIV-associated neurocognitive disorders (HAND): A meta-analysis and systematic review
Authors: Zondo Sizwe 
Published: September 2023

Background: Despite medical advances in Highly Active Antiretroviral Therapy (HAART), patients living with HIV continue to be at risk for developing HIV-associated neurocognitive disorders (HAND). The optimization of non-HAART interventions, including cognitive rehabilitation therapy (CRT), shows promise in reversing the impact of HAND. No data exist indicating the efficacy of CRT in remediating attention skills following neuroHIV. This paper presents a meta-analysis of randomised and non-randomised controlled trials (RCTs) to remediate attention skills following HIV CRT. Methods: The database search included literature from Google Scholar, ERIC, Cochrane Library, ISI Web of Knowledge, PubMed, PsycINFO, and grey literature published between 2013 and 2022. Inclusion criteria included studies with participants living with HIV who had undergone CRT intervention to remediate attention skills following neuroHIV. Exclusion criteria included case studies, non-human studies, and literature reviews. To assess study quality, including, randomisation, allocation concealment, participant and personnel blinding, the Cochrane Collaboration ratings system was applied. Results: A total of 14 studies met the inclusion criteria (n = 532). There were significant pre- to post-intervention between-group benefits due to CRT in the experimental group relative to control conditions for the remediation of attention skills following HIV acquisition (Hedges g = 0.251, 95% CI = 0.005 to 0.497; p < 0.05). No significant effects (p > 0.05) were demonstrated for subgroup analysis. Conclusions: To the author's knowledge, this is the first meta-analysis that exclusively analyses the remediation of attention skills in the era of HAART and neuroHIV, where all studies included participants diagnosed with HIV. The overall meta-analysis effect indicates the efficacy of CRT in remediating attention skills in HIV and HAND. It is recommended that future cognitive rehabilitation protocols to remediate attention skills should be context and population-specific and that they be supplemented by objective biomarkers indicating the efficacy of the CRT. Registration: Protocols.io (01/03/2023).
The discourse of organizational resilience before and after the global pandemic
Authors: Harsanto Budi , Firmansyah Egi Arvian 
Published: September 2023

Background: Over the past decade, there has been a surge in public and academic discussions about organizational resilience, particularly in the wake of the coronavirus disease (COVID-19) pandemic. It is essential to understand the changes in the discourse of organizational resilience before and after the pandemic. This study aims to understand how the concept of organizational resilience evolved before and after the pandemic. Methods: This study is qualitative in nature, employing discourse analysis techniques on scholarly documents on organizational resilience. Our analysis considers the global context of organizational resilience discussions and highlights the most frequently discussed industries, such as tourism and hospitality, manufacturing, and healthcare. The documents were searched on Scopus academic databases with the key search term of organizational AND resilience. Results: Our findings indicate that themes related to "response to external threats" and "supply chain vulnerabilities and disruptions" have gained significant attention post-pandemic. Meanwhile, discussions around "preparedness and organizational reliability" and "coping with occupational and job demands" have remained consistent before and after the pandemic. Conclusions: This study contributes to the academic understanding and practical application of organizational resilience evolution by discourse before and after the pandemic. It highlights the significance of being prepared for external threats and managing supply chain disruptions while recognizing the importance of preparedness and organizational reliability.
A cross sectional study to assess prevalence of internet addiction and its relationship with personality traits and associated psychiatric conditions in undergraduate medical students of an Indian university
Authors: Chadha Yatika , Patil Ragini 
Published: September 2023

Background: In India, 622 million internet users were found out of which our nationally representative data suggest that about 20% to 40% of college students in India are at risk for internet addiction (IA). Therefore, the research on its addiction is on the rise and is an established concern. Objectives: To study the prevalence of internet addiction in undergraduate medical graduates associating its impact, on personality traits and psychiatric conditions like depression, anxiety and stress. Methods: It is a cross sectional study based on undergraduate medical students of Jawaharlal Nehru Medical College, Wardha. It is a convenience based sampling method and a Krejcie-Morgan Formula is used. Using this, the sample size came out to be 300. Clearance from the ethics committee will be obtained. An informed consent from the students will be taken, thereafter they will be asked to fill socio demographic data and then will be subjected to the following questionnaires: 1)Young’s Internet addiction test 2) DASS 21 3)Brief Big Five inventory scale Results: We will be able to determine the prevalence of internet addiction among medical students after we have the results from the aforementioned questionnaires, their personality traits and development of psychiatric co- morbidities like depression, anxiety and stress. Conclusions: We’ll be able to know the prevalence of internet addiction in medical students, their personality traits and the development of psychiatric co- morbidities like depression, anxiety and stress.
Case Report: Acute peritonitis inaugurating Crohn's disease with spontaneous perforation in the peritoneal cavity
Authors: Belhadj Anis , Khefacha Fahd , OMRY Ahmed , Touati Med Dheker , Saidani Ahmed , Chebbi Faouzi 
Published: September 2023

Background: Crohn's Disease is a chronic, idiopathic, and transmural inflammatory condition that mainly affects the distal ileum. It is characterized by intricate pathophysiology and numerous complications, some of which can be fatal. In this report, we present a case study of acute generalized peritonitis resulting from the perforation of a distal ileal loop, inaugurating the diagnosis of Crohn's disease. Case presentation: A 43-year-old patient presented with a clinical presentation of acute peritonitis. He had a one-year history of intermittent abdominal pain and diarrhea. As the maximum pain was in the right iliac fossa, an acute appendicitis complicated with peritonitis was considered and the patient underwent laparoscopic exploration, without morphologic exploration. Peroperative observation found an inflamed conglomerate of small bowel loops associated with sclerolipomatosis, and purulent peritonitis by perforation of a distal ileal loop, 40 cm from the ileocaecal valve. A peritoneal toilet, ileocaecal resection, and ileo-colostomy were performed. The postoperative course was uneventful. Discussion: Various complications may arise during the evolution of Crohn’s disease. However, fatal complication such as generalized peritonitis leading to the diagnosis is rare. The underlying pathophysiology of free perforation remains unknown. The most common site affected is the terminal ileum. The surgical treatment is based on a limited resection of the affected bowel segment, followed by a temporary stoma. A primary anastomosis can be performed in selected patients. Conclusion: Perforative peritonitis as an initial presentation of Crohn's disease is challenging. Surgery is obviously required for acute peritonitis, with limited resection with or without anastomosis.