bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the bidirectional link between cancer and dementia and the impact of cancer therapies on dementia risk: A systematic review and meta‐analysis
Authors: Ma Liwei , Tan Edwin C. K. , Goudey Benjamin , Jin Liang , Pan Yijun 
Published: January 2025

AbstractObservational studies on the cancer–dementia relationship have yielded controversial results. This study systematically reviews the evidence to clarify this association. We searched Embase, Global Health, Ovid Medline, and APA PsycInfo. Colorectal and lung cancers showed the greatest risk reduction for all‐cause dementia (ACD) and Alzheimer's disease (AD), respectively, while melanoma and colorectal cancers had the largest reduction in vascular dementia (VaD). Prostate cancer survivors on androgen deprivation therapy (ADT) had a higher risk of ACD/AD, while breast cancer patients on tamoxifen had a lower AD risk. Chemotherapy was linked to a reduced AD risk. ACD patients saw a 30% risk reduction for bladder, colorectal, and lung cancers, while AD patients had a ≈ 35% reduction for bladder and lung cancers. Our study urges clinicians to monitor cognitive function in cancer patients, especially those on ADT, tamoxifen, or chemotherapy and highlights the need for research into cancer–dementia mechanisms.Highlights
Cancer survivors have an 8% to 14% lower risk of dementia, while those with dementia have a 25% lower cancer risk.
Colorectal and non‐melanoma skin cancers were associated with reduced risks of all‐cause dementia (ACD; 16%/9%), Alzheimer's disease (AD; 13%/5%), and vascular dementia (VaD; 24%/9%).
Lung cancer reduced AD risk by 17%, and melanoma reduced VaD risk by 27%.
ACD and AD patients had lower risks of lung (30%/36%), bladder (32%/34%), breast (26%/20%), and colorectal (31%/28%) cancers.
Tamoxifen and chemotherapy reduced AD risk, while androgen deprivation therapy increased ACD risk.
Polyphenols as Wnt/β‐catenin pathway modulators: A promising strategy in clinical neurodegeneration
Authors: Utpal Biswajit Kumar , Roy Sajib Chandra , Zehravi Mehrukh , Sweilam Sherouk Hussein , Raja A. Dinesh , Haque M. Akiful , Nayak Chandan , Balakrishnan Senthilkumar , Singh Laliteshwar Pratap , Panigrahi Saswati , Alshehri Mohammed Ali , Rab Safia Obaidur , Minhaj Najmus Sakib , Emran Talha Bin 
Published: January 2025

AbstractPolyphenols, a diverse group of naturally occurring compounds found in plants, have garnered significant attention for their potential therapeutic properties in treating neurodegenerative diseases (NDs). The Wnt/β‐catenin (WβC) signaling pathway, a crucial player in neurogenesis, neuronal survival, and synaptic plasticity, is involved in several cellular mechanisms related to NDs. Dysregulation of this pathway is a hallmark in the development of various NDs. This study explores multiple polyphenolic compounds, such as flavonoids, stilbenes, lignans, and phenolic acids, and their potential to protect the nervous system. It provides a comprehensive analysis of their effects on the WβC pathway, elucidating their modes of action. The study highlights the dual function of polyphenols in regulating and protecting the nervous system, providing reassurance about the research benefits. This review provides a comprehensive analysis of the results obtained from both in vitro studies and in vivo research, shedding light on how these substances influence the various components of the pathway. The focus is mainly on the molecular mechanisms that allow polyphenols to reduce oxidative stress, inflammation, and apoptotic processes, ultimately improving the function and survival of neurons. This study aims to offer a thorough understanding of the potential of polyphenols in targeting the WβC signaling pathway, which could lead to the development of innovative therapeutic options for NDs.
Highly Tension‐Strained Copper Concentrates Diluted Cations for Selective Proton‐Exchange Membrane CO2 Electrolysis
Authors: Li Ye‐Cheng , Zhang Xiao‐Long , Tai Xiao‐Lin , Yang Xue‐Peng , Yu Peng‐Cheng , Dong Shi‐Chen , Chi Li‐Ping , Wu Zhi‐Zheng , Zhang Yu‐Cai , Sun Shu‐Ping , Lu Pu‐Gan , Zhu Lei , Gao Fei‐Yue , Lin Yue , Gao Min‐Rui 
Published: January 2025

AbstractElectrolysis of carbon dioxide (CO2) in acid offers a promising route to overcome CO2 loss in alkaline and neutral electrolytes, but requires concentrated alkali cations (typical ≥3 M) to mitigate the trade‐off between low pH and high hydrogen evolution reaction (HER) rate, causing salt precipitation. Here we report a strategy to resolve this problem by introducing tensile strain in a copper (Cu) catalyst, which can selectively reduce CO2 to valuable multicarbon products, particularly ethylene, in a pH 1 electrolyte with 1 M potassium ions. We find that the tension‐strained Cu creates an electron‐rich surface that concentrates diluted potassium ions, contributing to CO2 activation and HER suppression. With this catalyst, we show constant ethylene Faradaic efficiency (FE) of 44.3 % over 100 hours at 400 mA cm−2 and a cell voltage of 3.1 volts in a proton‐exchange membrane electrolyser. Moreover, selective electrosynthesis of ethylene oxide using the as‐produced ethylene was demonstrated in an integrated system.
A photosynthesis‐derived bionic system for sustainable biosynthesis
Authors: Chen Na , Shen Ruichen , He Tianpei , Xi Jing , Zhao Rui , Du Na , Yang Yangbing , Yu Lilei , Yuan Quan 
Published: January 2025

Abstract“Cell factory” strategy based on microbial anabolism pathways offers an intriguing alternative to relieve the dependence on fossil fuels, which are recognized as the main sources of CO2 emission. Typically, anabolism of intracellular substance in cell factory requires the consumption of sufficient reduced nicotinamide adenine dinucleotide /nicotinamide adenine dinucleotide phosphate NAD(P)H and adenosine triphosphate ATP. However, it is of great challenge to modify the natural limited anabolism and to increase the insufficient level of NAD(P)H and ATP to optimum concentrations without causing metabolic disorder. Inspired by the natural photosynthesis process in which NAD(P)H and ATP can both be produced through the coupled electron‐proton transfer processes driven by sunlight, herein we designed a light‐driven bionic system composed of three modules including photo‐induced electron module, electron transfer channel module and proton gradient module. The proposed strategy of light‐driven bionic system enables for achieving simultaneous and controllable supplies of NAD(P)H and ATP, thus facilitating both highly efficient CO2 fixation and biomanufacturing. The proposed light‐driven bionic system design strategy in this work might pave new sustainable ways for reducing power and energy regeneration to optimize microbial metabolism, offering intriguing alternatives for CO2 emission mitigation and high‐value chemical biomanufacturing.
Copper‐Catalysed Electrochemical CO2 Methanation via the Alloying of Single Cobalt Atoms
Authors: Li Jiawei , Wei Miaojin , Ji Bifa , Hu Sunpei , Xue Jing , Zhao Donghao , Wang Haoyuan , Liu Chunxiao , Ye Yifan , Xu Jilong , Zeng Jie , Ye Ruquan , Zheng Yongping , Zheng Tingting , Xia Chuan 
Published: January 2025

AbstractThe electrochemical reduction of carbon dioxide (CO2) to methane (CH4) presents a promising solution for mitigating CO2 emissions while producing valuable chemical feedstocks. Although single‐atom catalysts have shown potential in selectively converting CO2 to CH4, their limited active sites often hinder the realization of high current densities, posing a selectivity‐activity dilemma. In this study, we developed a single‐atom cobalt (Co) doped copper catalyst (Co1Cu) that achieved a CH4 Faradaic efficiency exceeding 60 % with a partial current density of −482.7 mA cm−2. Mechanistic investigations revealed that the incorporation of single Co atoms enhances the activation and dissociation of H2O molecules, thereby lowering the energy barrier for the hydrogenation of *CO intermediates. In situ spectroscopic experiments and density functional theory simulations further demonstrated that the modulation of the *CO adsorption configuration, with stronger bridge‐binding, favours deep reduction to CH4 over the C−C coupling or CO desorption pathways. Our findings underscore the potential of Co1Cu catalysts in overcoming the selectivity‐activity trade‐off, paving the way for efficient and scalable CO2‐to‐CH4 conversion technologies.
Zero‐Valent Copper Catalysis Enables Regio‐ and Stereoselective Difunctionalization of Alkynes
Authors: Prakash Aishwarya , Basappa Suma , Urkude Rajashri R. , Jangir Ravindra , Dhayal Rajendra S. , Kumar Bose Shubhankar 
Published: January 2025

AbstractThe development of a metallic copper‐based catalyst system remains a significant challenge. Herein, we report the synthesis of highly stable, active, and reusable Cu0 catalyst for the carboboration of alkynes using carbon electrophiles and bis(pinacolato)diboron (B2pin2) as chemical feedstocks to afford di‐ and trisubstituted vinylboronate esters in a regio‐ and stereoselective manner with appreciable turnover number (TON) of up to 2535 under mild reaction conditions. This three‐component coupling reaction works well with a variety of substituted electrophiles and alkynes with broad functional group tolerance. In addition, a wide range of terminal and challenging internal alkynes were efficiently converted into hydroborated products in up to >99 % yield with excellent regioselectivity in the absence of carbon electrophiles. X‐ray photoelectron spectroscopy and X‐ray absorption near‐edge spectroscopy (XANES) analysis confirm that the oxidation state of the copper in the catalyst is zero. The broad range of organic transformations, effectiveness, and recyclability of this Cu0 catalyst are the major achievements that provide an environmentally friendly route for the efficient production of tri‐ and tetrasubstituted olefins, key intermediates in organic synthesis. The gram‐scale reaction and synthetic transformations further highlights the usefulness of these methods.
Observation of the Smallest Three‐Dimensional Neutral Boron Cluster
Authors: Xu Cong‐Qiao , Wang Tiantong , Wang Chong , Dong Xin‐Ran , Zheng Huijun , Zhao Ya , Pan Li‐Li , Yang Jiayue , Zhang Weiqing , Wu Guorong , Xie Hua , Li Gang , Li Jun , Jiang Ling , Yang Xueming , Wang Lai‐Sheng 
Published: January 2025

AbstractDespite major progress in the investigation of boron cluster anions, direct experimental study of neutral boron clusters remains a significant challenge because of the difficulty in size selection. Here we report a size‐specific study of the neutral B9 cluster using threshold photoionization with a tunable vacuum ultraviolet free electron laser. The ionization potential of B9 is measured to be 8.45±0.02 eV and it is found to have a heptagonal bipyramid D7h structure, quite different from the planar molecular wheel of the B9‐ anionic cluster. Chemical bonding analyses reveal superior stability of the bipyramidal structure arising from delocalized σ and π bonding interactions within the B7 ring and between the B7 ring and the capping atoms. Photoionization of B9 breaks the single‐electron B‐B bond of the capping atoms, which undergo off‐axis distortion to enhance interactions with the B7 ring in the singlet ground state of B9+. The single‐electron B‐B bond of the capping atoms appears to be crucial in stabilizing the D7h structure of B9. This work opens avenues for direct size‐dependent experimental studies of a large variety of neutral boron clusters to explore the stepwise development of network structures.
Integrating Enzymes with Reticular Frameworks To Govern Biocatalysis
Authors: Tong Linjing , Huang Siming , Chen Guosheng , Ouyang Gangfeng 
Published: January 2025

AbstractIntegrating enzymes with reticular frameworks offers promising avenues for access to functionally tailorable biocatalysis. This Minireview explores recent advances in enzyme‐reticular framework hybrid biocomposites, focusing on the utilization of porous reticular frameworks, including metal‐organic frameworks, covalent‐organic frameworks, and hydrogen‐bonded organic frameworks, to regulate the reactivity of an enzyme encapsulated inside mainly by pore infiltration and in situ encapsulation strategies. We highlight how pore engineering and host‐guest interfacial interactions within reticular frameworks create tailored microenvironments that substantially impact the mass transfer and enzyme conformation, leading to biocatalytic rate enhancement, or imparting enzymes with non‐native biocatalytic functions, including substrate selectivity and new activity. Additionally, the feasibility of leveraging the photothermal effect of a framework to optimize the local reaction temperature and photoelectric effect to elicit diverse photoenzyme‐coupled reactions is also summarized in detail, which can expand the functional repertoire of biocatalytic transformations under light irradiation. This Minireview underscores the potential of reticular frameworks as tunable and reliable platforms to govern biocatalysis, offering pathways for engineering sustainable, efficient, and selective biocatalytic reactors in pharmaceutical, environmental, and energy‐related applications.
Amorphization Stabilizes Te‐Based Aqueous Batteries via Confining Free Water
Authors: Zhang Yanyan , Zhou Wanhai , Wang Boya , Zhang Tengsheng , Yu Xiaoyu , Li Xinran , Li Gaoyang , Jin Hongrun , Chen Minghua , Li Wei , Zhao Dongyuan , Liu Xin , Chao Dongliang 
Published: January 2025

AbstractTellurium (Te), with its rich valence states (−2 to +6), could endow aqueous batteries with potentially high specific capacity. However, achieving complete and stable hypervalent Te0/Te4+ electrochemistry in an aqueous environment poses significant challenges, owing to the sluggish reduction kinetics, easy dissolution of Te4+ species, and a controversial energy storage mechanism. Herein, we demonstrate a crystallographic regulation strategy for robust aqueous Te redox electrochemistry. With strong hydrogen bonding, NH4Ac confines free water, prompting the amorphization of TeO2 (a‐TeO2). In situ synchrotron characterization, spectroscopy analysis, electrochemical evaluation, and theoretical calculations reveal a specific 4 e− solid‐solid transition pathway (Te to a‐TeO2) with accelerated diffusion and charge transfer kinetics, attributed to a closer unoccupied electron orbital to the Fermi level and a reduced water desorption energy barrier in a‐TeO2. Impressively, the a‐TeO2/Te redox exhibits a high reversible capacity of 834 mAh g−1 (99% of Te redox utilization), superior rate performance (644 mAh g−1 at 10 A g−1), and an ultralong lifespan (over 3000 cycles). These findings prove a new tactic to advance aqueous Te redox electrochemistry toward high‐energy aqueous batteries.
A Two‐in‐One Strategy to Simultaneously Boost the Site Density and Turnover Frequency of Fe−N−C Oxygen Reduction Catalysts
Authors: Liu Jianbin , Liu Yao , Nan Bing , Wang Dashuai , Allen Christopher , Gong Zhichao , He Guanchao , Fu Kaixing , Ye Gonglan , Fei Huilong 
Published: January 2025

AbstractSite density (SD) and turnover frequency (TOF) are the two fundamental kinetic descriptors that determine the oxygen reduction activity of iron‐nitrogen‐carbon (Fe−N−C) catalysts that represent the most promising alternatives to precious and scarce platinum. However, it remains a grand challenge to simultaneously optimize these two parameters in a single Fe−N−C catalyst. Here we show that treating a typical Fe−N−C catalyst with ammonium iodine (NH4I) vapor via a one‐step chemical vapor deposition process not only increases the surface area and porosity of the catalyst (and thus enhanced exposure of active sites) via the etching effect of the in situ released NH3, but also regulates the electronic structure of the Fe−N−C moieties by the iodine dopants incorporated into the carbon matrix. As a result, the NH4I‐treated Fe−N−C catalyst possesses both high values in the SD of 2.15×1019 sites g−1 (×2 enhancement compared to the untreated counterpart) and TOF of 3.71 electrons site−1 s−1 (×3 enhancement) that correspond to a high mass activity of 12.78 A g−1, as determined by in situ nitrite stripping technique. Moreover, this catalyst exhibits an excellent oxygen reduction activity in base with a half‐wave potential (E1/2) of 0.924 V and acceptable activity in acid with E1/2 =0.795 V, and superior power density of 249.1 mW cm−2 in a zinc‐air battery.
Thiazolidinone‐Based Electron‐Collecting Monolayers for n‐i‐p Perovskite Solar Cells
Authors: Miyake Yuki , Nakamura Tomoya , Truong Minh Anh , Murdey Richard , Wakamiya Atsushi 
Published: January 2025

AbstractThe development of efficient electron‐collecting monolayer materials is desired to lower manufacturing costs and improve the performance of regular (negative‐intrinsic‐positive, n‐i‐p) type perovskite solar cells (PSCs). Here, we designed and synthesized four electron‐collecting monolayer materials based on thiazolidinone skeletons, with different lowest‐unoccupied molecular orbital (LUMO) levels (rhodanine or thiazolidinedione) and different anchoring groups to the transparent electrode (phosphonic acid or carboxylic acid). These molecules, when adsorbed on indium tin oxide (ITO) substrates, lower the work function of ITO, decreasing the energy barrier for electron extraction at the ITO/perovskite interface and improving the device performance. The shift of work function, rather than the LUMO levels of the molecules themselves, was found to be correlated with the performance of the perovskite solar cells.
Die qualifizierte Führungskraft (QuF)
Authors: Motzke Gerd 
Published: January 2025

AbstractDas mangelfreie Gelingen eines Instandhaltungs‐Werks bedingt das kluge und sorgfältige Tätigwerden vieler Planer und Baubeteiligter. Denn der Auftraggeber stellt ein Bauwerk, das der Instandhaltung/Instandsetzung bedarf. Dieses instandhaltungs‐/instandsetzungsbedürftige Bestandsobjekt ist der vom Auftraggeber gestellte „Baustoff“, der der Untersuchung und Bewertung bedarf, um darauf aufbauend das Instandhaltungs‐/Instandsetzungsziel bestimmen und die darauf ausgerichtete Instandhaltungsplanung erstellen zu können. Diese geistige Leitung, die den Einsatz spezieller Planer – Sachkundiger Planer (SKP) – bedarf, bewirkt jedoch für sich nichts. Die Planungsleistung muss umgesetzt werden, also muss entsprechend der Planung gleichsam an den „Baustoff“ – das Bestandsobjekt – Hand angelegt werden. Hierfür bedarf es des fachkundigen Unternehmers – Verarbeiter –, der seinerseits fachkundiges Personal einzusetzen hat. Denn ohne qualifiziertes Personal ist der Verarbeiter nicht in der Lage, das beauftragte Instandsetzungswerk unter Berücksichtigung des vorgefundenen Istzustands mangelfrei entsprechend den vertraglichen Anforderungen zu erstellen. Wie der Sachkundige Planer (SKP) auf der Auftraggeberseite tätig wird, wirkt auf der Auftragnehmerseite unter anderem – neben dem Bauleiter, dem Baustellenfachpersonal und dem Baustellenpersonal (Teil 3 der DAfStb‐Richtlinie Schutz und Instandsetzung von Betonbauteilen (Instandsetzungsrichtlinie, Rili, 2001 [1]) – die Qualifizierte Führungskraft (QuF). Deren Aufgabe, Funktion und Verantwortung soll näher beleuchtet und zusätzlich dargestellt werden, was diesbezüglich als Begründung nach Technik‐ und Rechtsregeln einschlägig ist. Diese hohe Verantwortlichkeit eines Beschäftigten eines Unternehmers – Verarbeiter –, der diesem die Aufgabe der QuF arbeitsrechtlich zugewiesen hat, hat notwendig zur Folge, dass der Unternehmer die Voraussetzungen schaffen muss, damit die QuF überhaupt in der Lage ist, der gestellten Aufgabe verantwortlich gerecht zu werden.
Management of Acute Coronary Syndrome in Patients With Transcatheter Aortic Valve Replacement: A Review
Authors: Hirsch Joshua R. , Mascarenhas Lorraine , Kayani Waleed T. , Denktas Ali E. , Khalid Mirza U. , Liu Jing 
Published: January 2025

ABSTRACTTranscatheter aortic valve replacement (TAVR) has become a viable treatment option for patients with severe aortic stenosis among all risk subsets. As TAVR use becomes more prevalent and patients live longer with their transcatheter valve, an increasing number of these patients can be expected to present with ACS. Overall, there is a paucity of high‐quality data detailing incidence, pathophysiology, and management of ACS in this subset. While most ACS cases post‐TAVR are Type II myocardial infarctions (MI), the incidence of Type I MI and ST‐elevation myocardial infarction is not negligible. Additionally, ACS in TAVR patients is associated with poor outcomes. While medical management is similar in this cohort to non‐TAVR patients, procedural issues pose a unique challenge, especially as related to coronary access in the presence of valve prosthesis. Despite the proven benefit of invasive therapies in the management of ACS in non‐TAVR patients, administrative databases suggest a lower utilization of invasive therapies in this cohort, which may highlight a disparity in care and potential for improvement. In this review, we summarize available data regarding the incidence, pathophysiology, and management of ACS in TAVR patients as well as strategies for coronary access post‐TAVR.
Intra‐Aortic Balloon Pump: Down But Not Out
Authors: Guddeti Raviteja R. , Henry Timothy D. 
Published: January 2025

Key Points

IABP use in AMI‐CS has declined in the USA and elsewhere, secondary to the lack of significant mortality benefit and the availability of alternative devices with higher levels of support.
Alternative indications for IABP use continue to exist, including ADHF‐CS and mechanical complications from AMI.
Careful patient selection is critical in identifying responders to IABP. Further studies are needed to clarify the appropriate indications for IABP.
Angiographic Characterization and Sex‐Related Anatomical Differences of Atrial Coronary Arteries Anatomy—A Proposal of Systematic Classification
Authors: Marques‐ Antunes Miguel , van Oort Martijn J. H. , Oliveri Federico , Al Amri Ibtihal , Bingen Brian O. , Cruz‐Ferreira Rui , Wouter Jukema J. , Montero‐Cabezas Jose M. 
Published: January 2025

ABSTRACTBackgroundThe coronary atrial circulation is the network of vessels that supply blood to the atria, originating from the left circumflex and right coronary arteries. Current descriptions of this arterial system are based on anatomical studies with a limited number of patients, predominantly male. In addition, there is a lack of consensus its angiographic nomenclature.AimsThis study aimed to evaluate the anatomical variations of coronary atrial branches (CAB) and investigate sex‐related differences in their distribution.MethodsConsecutive patients with ST‐elevation myocardial infarction who underwent primary PCI at a tertiary center between 2004 and 2013 were included. Angiographic anatomy of all visible CAB on index coronary angiography was systematically evaluated following a stepwise method, including type of branch; coronary artery of origin; segment of origin, branch course, and atrial dominancy. Specific differences between both sexes were analyzed.ResultsA total of 998 patients (age 61 ± 12, 79% male) were included. The sinus node artery was the dominant CAB in 916 (93%), originating in 37% from distal coronary segments. Different CAB anatomical patterns were identified in both sexes. Compared to females, males presented a higher prevalence of left‐sided CAB (left circumflex CAB 459 [58%] vs. 96 [45%], p < 0.001; sigma‐shaped CAB 267 [30%] vs. 39 [21%], p = 0.003) and of a left‐balanced atrial circulation pattern‐defined as the presence of at least two CAB originating from the LCx, with one of them being the dominant CAB—245 (31%) versus 45 (21%), p = 0.005.ConclusionsThis study provides a systematic approach to the angiographic evaluation of CAB. Sex‐related phenotypical differences of CAB distribution were found, with males presenting a higher presence of left‐sided CAB and a left‐balanced atrial circulation pattern.