bluuebunny/crossref_metadata_2025_split huggingface dataset:
Letter: faecal microbiota transplantation for irritable bowel syndrome—which improvements are required?
Authors: El‐Salhy Magdy , Hausken Trygve , Gunnar Hatlebakk Jan 
Published: September 2023

LINKED CONTENT
This article is linked to Lahtinen et al papers. To view these articles, visit https://doi.org/10.1111/apt.15942 and https://doi.org/10.1111/apt.16122
Editorial: the microbiome, aspirin and colorectal cancer—authors' reply
Authors: Prizment Anna E. , Onyeaghala Guillaume , Church Timothy R. 
Published: September 2023

LINKED CONTENTThis article is linked to Prizment et al and O’Grady & Quigley papers. To view these articles, visit https://doi.org/10.1111/apt.16013 and https://doi.org/10.1111/apt.16071
Letter: SARS‐CoV‐2 induced gastrointestinal inflammation—authors' reply
Authors: Taxonera Carlos , Alba Cristina 
Published: September 2023

LINKED CONTENTThis article is linked to Taxonera et al and Reuken et al papers. To view these articles, visit https://doi.org/10.1111/apt.15804 and https://doi.org/10.1111/apt.16087
Ustekinumab is effective and safe for ulcerative colitis through 2 years of maintenance therapy
Authors: Panaccione Remo , Danese Silvio , Sandborn William J. , O'Brien Christopher D. , Zhou Yiying , Zhang Hongyan , Adedokun Omoniyi J. , Tikhonov Ilia , Targan Stephan , Abreu Maria T. , Hisamatsu Tadakazu , Scherl Ellen J. , Leong Rupert W. , Rowbotham David S. , Arasaradnam Ramesh P. , Sands Bruce E. , Marano Colleen 
Published: September 2023

SummaryBackgroundThe ongoing UNIFI long‐term extension evaluates subcutaneous ustekinumab for moderate‐to‐severe ulcerative colitis (UC) from weeks 44 through 220.AimsTo assess efficacy (through week 92) and safety (through week 96) during the long‐term extensionMethodsOverall, 399 responders to intravenous ustekinumab induction and who were randomised to maintenance therapy were treated in the long‐term extension (115 received subcutaneous placebo, 141 received ustekinumab 90 mg every 12 weeks [q12w], and 143 received ustekinumab 90 mg q8w). Placebo treatment was discontinued at unblinding after week 44. Partial Mayo scores were collected every 12 weeks and at each dosing visit after unblinding. Safety was evaluated throughout.ResultsAmong all patients randomised in maintenance, symptomatic remission rates (stool frequency = 0/1; rectal bleeding = 0) at week 92 were, 64.5% and 67.6% in the ustekinumab q12w and q8w groups, respectively. Among randomised patients treated in the long‐term extension, 78.7% and 83.2% of patients receiving q12w and q8w, respectively, attained symptomatic remission at week 92; >95% of patients in symptomatic remission at week 92 were corticosteroid‐free. Both ustekinumab groups maintained efficacy through week 92. From weeks 44 to 96, adverse events (AEs) per hundred patient‐years (PY) of follow‐up for combined ustekinumab vs placebo were: 255.68 vs 267.93; serious AEs, 9.34 vs 12.69; malignancies (including non‐melanoma skin cancers), 0.93 vs 1.49; and serious infections, 2.33 vs 2.99. One patient with multiple comorbidities who received one ustekinumab dose after dose adjusting from placebo experienced a fatal cardiac arrest.ConclusionsThe efficacy of ustekinumab in patients with UC was sustained through 92 weeks. No new safety signals were observed (ClinicalTrials.gov number, NCT02407236).
Letter: elevated aspartate aminotransferase and aspartate aminotransferase to alanine aminotransferase ratio predicts poor survival in hepatocellular carcinoma after resection—Authors' reply
Authors: Wai‐Sun Wong Vincent , Kao Jia‐Horng 
Published: September 2023

LINKED CONTENTThis article is linked to Kao et al and Li et al papers. To view these articles, visit https://doi.org/10.1111/apt.16097 and https://doi.org/10.1111/apt.16124
Keeping up with COVID‐19 information: Capacity issues and knowledge uncertainty early in the pandemic
Authors: Albert Katelin , Gray Garry 
Published: September 2023

AbstractThis article examines the relationship between information consumption and mental health during the early stages of the COVID‐19 pandemic. Adopting a qualitative approach, we interviewed 39 people in British Columbia, Canada between October and December 2020. Interestingly, half of the participants did not want to seek out new information on COVID‐19, making their early insights and initial confusion salient. While some individuals did desire up‐to‐date information on outbreaks and new risks, many expressed confusion over what was perceived to be an evolving landscape of public health policy and practice. Overall, our research found that capacity issues, information overload/fatigue, politics, distrust, and competing sources of news all contributed to a culture of confusion towards public health information. As a consequence, this confusion resulted in knowledge uncertainty about the virus, vaccinations, and the pandemic itself. Our findings highlight the need for a host of future projects that examine how citizens experience disempowerment and limited agency towards compliance with health and safety initiatives.
Sources of mathematics self‐efficacy: The interactive role of parental education and perceptions of teachers
Authors: Dangur‐Levy Shahar , Andersen Robert , Holm Anders 
Published: September 2023

AbstractUsing US National Education Longitudinal Study (NELS) data, we explore how parental education and primary students’ perceptions of their teachers interact to impact students’ self‐efficacy in mathematics. Our results demonstrate that students tend to have higher self‐efficacy if they perceive that their teacher promotes the importance of mathematics. This relationship holds regardless of parental education, though it is strongest for children of parents without a university education. Children of less educated parents also tend to have lower self‐efficacy if they attend private schools, which typically have high average parental socio‐economic status (SES). School type has no discernable impact on children of university‐educated parents. These findings are highly relevant to the Canadian context, which is characterized by schools being stratified by SES and the high importance of STEM education for occupational outcomes.
Transcriptome sequencing of circular RNA reveals the involvement of hsa‐SCMH1_0001 in the pathogenesis of Parkinson's disease
Authors: Wang Qiao , Wang Huizhi , Zhao Xuemin , Han Chunlei , Liu Chong , Li Zhibao , Du Tingting , Sui Yunpeng , Zhang Xin , Zhang Jianguo , Xiao Yilei , Cai Guoen , Meng Fangang 
Published: September 2023

AbstractBackgroundParkinson's disease (PD) is the second most common neurodegenerative disease. Exosomes are endosome‐derived extracellular vesicles that can take part in intercellular communication. Circular RNAs (circRNAs) are noncoding RNAs characterized by covalently closed‐loop structures, which perform a crucial function in many diseases.AimTo clarify the expression and function of exosomal circRNSs of PD patients and look for circRNAs that might be related to the pathogenesis of PD.Materials and MethodsWe examined circRNA and mRNA expression profiles in peripheral exosomes from PD patients (n = 23) and healthy controls (n = 15) using next‐generation sequencing (NGS) technology, functional annotation, and quantitative polymerase chain reaction. Correlation analysis was performed between the expression levels of the circRNAs and the clinical characteristics of PD patients. The binding miRNAs and target genes were predicted using TargetScanHuman, miRDB, and miRTarBase. The predicted target genes were compared with the differentially expressed mRNAs in sequencing results.ResultsAccording to the NGS, 62 upregulated and 37 downregulated circRNAs in the PD group were screened out. Correlation analysis revealed that hsa‐SCMH1_0001 has strong clinical relevance. We identified 17 potential binding miRNAs of hsa‐SCMH1_0001 with 149 potential target genes. ARID1A and C1orf115 belong to the intersection of the predicted target genes and the differentially expressed mRNAs obtained by sequencing.ConclusionThis study suggested that hsa‐SCMH1_0001 and its target genes ARID1A and C1orf115 are downregulated in PD patients and may be involved in the occurrence of PD.
Binding of RAGE and RIPK1 induces cognitive deficits in chronic hyperglycemia‐derived neuroinflammation
Authors: Zhou Xiaoyan , Zhu Yandong , Gao Lin , Li Yan , Li Hui , Huang Chengyu , Liu Yan , Hu Ankang , Ying Changjiang , Song Yuanjian 
Published: September 2023

AbstractAimsChronic hyperglycemia‐induced inflammation of the hippocampus is an important cause of cognitive deficits in diabetic patients. The receptor for advanced glycation end products (RAGE), which is widely expressed in the hippocampus, is a crucial factor in this inflammation and the associated cognitive deficits. We aimed to reveal the underlying mechanism by which RAGE regulates neuroinflammation in the pathogenesis of diabetes‐induced cognitive impairment.MethodsWe used db/db mice as a model for type 2 diabetes to investigate whether receptor‐interacting serine/threonine protein kinase 1 (RIPK1), which is expressed in microglia in the hippocampal region, is a key protein partner for RAGE. GST pull‐down assays and AutoDock Vina simulations were performed to identify the key structural domain in RAGE that binds to RIPK1. Western blotting, co‐immunoprecipitation (Co‐IP), and immunofluorescence (IF) were used to detect the levels of key proteins or interaction between RAGE and RIPK1. Cognitive deficits in the mice were assessed with the Morris water maze (MWM) and new object recognition (NOR) and fear‐conditioning tests.ResultsRAGE binds directly to RIPK1 via the amino acid sequence (AAs) 362–367, thereby upregulating phosphorylation of RIPK1, which results in activation of the NLRP3 inflammasome in microglia and ultimately leads to cognitive impairments in db/db mice. We mutated RAGE AAs 362–367 to reverse neuroinflammation in the hippocampus and improve cognitive function, suggesting that RAGE AAs 362–367 is a key structural domain that binds directly to RIPK1. These results also indicate that hyperglycemia‐induced inflammation in the hippocampus is dependent on direct binding of RAGE and RIPK1.ConclusionDirect interaction of RAGE and RIPK1 via AAs 362–367 is an important mechanism for enhanced neuroinflammation in the hyperglycemic environment and is a key node in the development of cognitive deficits in diabetes.
Bernard Williams on the guise of the good
Authors: Orsi Francesco 
Published: September 2023

AbstractThe guise of the good is the thesis that an agent can only want, or intentionally do or pursue something, if and because this seems good to the agent in some respect or other. Bernard Williams criticizes the guise of the good in Ethics and the Limits of Philosophy. In this paper I reconstruct and assess his hitherto unnoticed critical remarks. Williams's opposition is based on the idea that it takes an “extra step” to go from desiring or pursuing something to thinking of it as good. To show this, he employs an argument from elimination (with two strands: an argument from personal ends and an argument from immediate ends), and a separate argument which I call the one‐desire argument. I review and reject two types of answers to Williams's objections: answers that explore different varieties of what it can mean to “think of as good,” and answers that focus on different varieties of goodness under the guise of which one can desire something. I then consider whether a different, but nearby thesis, namely the guise of normative reasons, can accommodate Williams's objections, concluding that this alternative also fails. I end by looking at how this debate might move forward.
Speech recognition and artificial intelligence based on the development of music system
Authors: Chi Jinjing 
Published: September 2023

AbstractIn the face of this increasingly intelligent society and home life, it is necessary to research and design more intelligent music systems to meet people's needs. This paper uses music speech recognition algorithms when building a music system, and combines artificial intelligence technology to apply cloud‐computing technology to the processing and transmission of music data. The system is formed by the fusion of various technologies. At the same time, using embedded technology as the core can handle multiple tasks at the same time, thereby effectively improving the efficiency of the system. In addition, based on speech recognition technology, this paper combines artificial intelligence to develop music systems. Through experimental analysis, it can be seen that the music system based on speech recognition and artificial intelligence proposed in this paper has good results.
Idiosyncratic trends of woodland invertebrate biodiversity in Britain over 45 years
Authors: Bowler Diana E. , Cunningham Charles A. , Beale Colin M. , Emberson Lisa , Hill Jane K. , Hunt Merryn , Maskell Lindsay , Outhwaite Charlotte L. , White Piran C. L. , Pocock Michael J. O. 
Published: September 2023

Abstract
Woodland cover in Britain has increased over the past century and is set to increase further through woodland creation schemes aiming to tackle climate change. Nonetheless, the wider repercussions of increasing woodland cover for species, especially invertebrates, have not been comprehensively assessed.
Here, we quantified the woodland associations of 2762 invertebrate species in Britain across 21 broad taxon groups using species occurrence records collected by specialist recording societies. We then related the strength of species' woodland associations to published estimates of their long‐term national distribution trends between 1970 and 2015.
Across all taxa, 29% of species were positively associated with broadleaf woodland cover, whereas 27% of species were negatively associated. There was a slight tendency for species associated with broadleaf woodland to have more positive long‐term distribution trends, but the effect had little explanatory power. For 15% of species, we detected a non‐monotonic association with broadleaf woodland cover, such that their occurrence peaked at intermediate levels of cover. Intermediate‐cover species had more positive long‐term distribution trends than species with monotonic positive or negative woodland associations.
Our findings suggest that woodland invertebrates have not consistently increased, despite the increases in woodland cover. While some caution is warranted owing to our use of heterogeneous occurrence records, the considerable variation in distribution trends of woodland‐associated species could be explained by the high diversity of woodland species and ways in which they use woodland habitat. Woodland creation, or increasing tree cover in general, could have idiosyncratic impacts on species, depending on how new woodlands are created and managed.
Influence of nervous tendencies on oral health status and lifestyle habits
Authors: Fukuike Hisae , Noda Megumi , Ibaraki Hiroko , Sasaki Karin , Tanaka Yuimi , Suzuki Hidenori , Ishimaru Masahiko 
Published: September 2023

AbstractObjectiveIt is presumed that people with nervous tendencies brush their teeth for long durations, and, we aimed to investigate how nervous tendencies affect oral health status and lifestyle habits.Subjects and methodsThree hundred and sixty patients who visited the Senri Dental Clinic, affiliated with the Sunstar Foundation, and were being treated for periodontal diseases between 11 January 2017 and 10 April 2017 were enrolled. A total of 323 respondents (101 men and 222 women) were considered eligible. Nervous tendencies were investigated using the Fujinami neurotic index (FNI) and its derivative, the neurotic index (NI). Patients with NIs of ≥20 were included in the ‘needs caution’ group, whereas those with NIs of <19 comprised the ‘healthy’ group. The plaque score; periodontal pocket depth; bleeding on probing degree; gingival recession; crevice defects; oral conditions, such as cervical fillings and lifestyle habits were compared between the groups.Results and discussionNo statistically significant differences in oral status were observed between the groups. On the other hand, the needs caution group had significantly longer brushing durations and lower usage of auxiliary teeth cleaning tools than the healthy group. Sleep duration was significantly shorter in the needs caution group than in the healthy group.ConclusionsPatients with strong nervous tendencies had long oral brushing durations and low usage of auxiliary cleaning tools. However, these factors did not negatively affect oral health status. These results could aid in understanding patients with strong nervous tendencies and in developing appropriate dental health guidance measures.
The role of self‐compassion in mediating the effect of perfectionism on personal growth initiative in dental hygienists
Authors: Laliberte Michaela , Boyd Linda D. , Perry Kristeen R. , Vineyard Jared 
Published: September 2023

AbstractObjectiveThis study explored perfectionism, self‐compassion and personal growth initiative in clinical dental hygienists.MethodsCross‐sectional survey research was conducted with a non‐probability sample of clinical dental hygienists (n = 877). The survey had 55 items and consisted of three validated instruments: Frost's Multidimensional Perfectionism Scale—Brief (including evaluative concerns and perfectionistic striving subscales), Neff's Self‐Compassion Scale and Robitschek's Personal Growth Initiative Scale. Descriptive, correlation, t‐test, ANOVA and logistic regression analyses were used to evaluate the relationships among variables. Mediation analysis was conducted to determine the presence of a mediated moderation effect of self‐compassion on perfectionism and personal growth initiative.ResultsThe completion rate for the survey was 89% (n = 788). Evaluative concerns (M = 11.83) and perfectionistic strivings (M = 15.44) among dental hygienists were high, levels of self‐compassion (SC) were moderate (M = 2.87) and levels of personal growth initiative (PGI) were low (M = 38.07) compared to others not in the dental field. The mediation analysis found that SC mediates the relationship between perfectionistic evaluative concerns and PGI. It was also determined that SC mediates the relationship between perfectionistic strivings and PGI.ConclusionDental hygienists have high levels of perfectionism and may lack necessary levels of self‐compassion to counteract those perfectionistic tendencies resulting in a decrease in taking the initiative to engage in opportunities for growth. This suggests the importance of dental hygienists developing a more adaptive perfectionism to balance self‐criticism along with not having unrealistic expectations for perfection while engaging in self‐compassion that includes self‐kindness and mindfulness to support their continued growth.
High‐throughput laser‐based surface functionalization for fabrication of superhydrophobic soda‐lime glass
Authors: Wang Qinghua , Liu Chao , Yin Kai , Zhou Yongqi , Wang Huixin 
Published: September 2023

AbstractRendering transparent materials extreme wettability, for example, superhydrophobicity or superhydrophilicity, has received considerable attention during the past decades. While fabrication of superhydrophobic glass with high processing efficiency and low production cost has always been a challenge. In this work, a laser‐based surface functionalization process that combines ultraviolet (UV) nanosecond laser texturing and silicone oil‐assisted heat treatment was employed to render glass superhydrophobicity with high process throughput. The wettability transition is attributed to the combined effects of laser texturing that induces hierarchical surface micro/nanostructures and silicone oil‐assisted heat treatment that alters surface chemistry and lowers surface energy. The surface transmittance of the laser‐based surface functionalized glass samples in the visible spectrum was experimentally measured and analyzed. The laser‐based surface functionalized glass sample also exhibited long‐term stability in air, mechanical robustness and good self‐cleaning property. More importantly, the developed process shows both high process efficiency and cost effectiveness and has potential for applications where superhydrophobic glass is required.
Ultrasonic‐assisted and enzymatic‐assisted extraction to recover tannins, flavonoids, and terpenoids from used tea leaves using natural deep eutectic solvents
Authors: Vo Tan Phat , Tran Ton Quoc Dao , Phan Thuy Han , Huynh Hoang Duy , Vo Thi Thanh Yen , Vo Nguyen Minh Khoi , Ha Mai Phuong , Le Thao Nhien , Nguyen Dinh Quan 
Published: September 2023

SummaryThe conventional extraction technique using organic solvent was employed to recover bioactive compounds from plants; however, this technique showed low efficiency and caused environmental pollution. Novel extraction techniques such as ultrasound‐assisted extraction (UAE) and enzymatic‐assisted extraction (EAE) combined with natural deep eutectic solvent were developed to overcome this problem. The efficiency of a binary NADES system with sonication was evaluated based on total tannin contents (TTAC), total flavonoid content (TFC), and total terpenoid content (TTC). The NADES system with a molar ratio of acetic acid and glycerol at 2:1 showed the highest TTAC and TFC, while acetic acid and glucose at 2:1 yielded the highest TTC. The impact of UAE and EAE parameters on extraction yield was examined. Combined methods, including ultrasonic‐enzymatic assisted extraction (UEAE), enzymatic‐ultrasonic assisted extraction (EUAE), and simultaneous ultrasonic‐enzymatic assisted extraction (SUEAE), were performed using NADES. UEAE exhibited the highest extraction yield and biological activities. Scanning electron microscopy (SEM) was employed to examine the surface variations of used tea leaves before and after treatment. This study demonstrated that UEAE is a sustainable technique for recovering valuable compounds from used tea leaves.