bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro
Authors: Han Jinrun , Wu Jinhao , Liu Hong , Huang Yu , Ju Wen , Xing Yifei , Zhang Xiaoping , Yang Jun 
Published: July 2023

Abstract
Acute kidney injury is a fatal disease characterized by a rapid deterioration of kidney function. Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is a natural product extracted from Capsicum. The aim of this study was to explore the protective effect of capsaicin on inflammation, apoptosis, and mitochondrial dysfunction in an in vitro model of acute kidney injury. Lipopolysaccharide (LPS)-induced acute kidney injury model was established in HK-2 cells to investigate the protective effect of capsaicin. Cell viability was assessed using CCK-8 assay, and protein expression was detected using western blot and immunofluorescence assay. Intracellular reactive oxygen species (ROS) level and mitochondrial membrane potential were analyzed by flow cytometry. Cell apoptosis was detected by propidium iodide staining. The results showed that capsaicin ameliorated LPS-induced cytotoxicity in vitro and attenuated the release of interleukin (IL)-1β and IL-18. Intriguingly, genipin abolished the protective effect of capsaicin. Molecularly, capsaicin activated transient receptor potential cation channel subfamily V member 1 –mitochondrial uncoupling protein 2 axis and inhibited caspase-1-mediated pyroptosis. In addition, capsaicin alleviated LPS-induced ROS production and mitochondrial membrane potential disruption and inhibited apoptosis. These findings suggest that capsaicin shows a protective effect in in vitro acute kidney injury model.
On the stability of a strongly stabilizing control for degenerate systems in Hilbert spaces
Authors: Hariri Mohamed , Bouteffal Zohra , Beghersa Nor-el-houda , Benabdallah Mehdi 
Published: July 2023

Abstract
In this article, we explain how a recent Lyapunov theorem on stability plays a role in the study of the strong stabilizability problem in Hilbert spaces. We explore a degenerate controlled system and investigate the properties of a feedback control to stabilize such system in depth. The spectral theory of an appropriate pencil operator is used to generate robustness constraints for a stabilizing control.
Existence and nonexistence of solutions for elliptic problems with multiple critical exponents
Authors: Li Yuanyuan 
Published: July 2023

Abstract
In this article, the existence and nonexistence of solutions for the quasilinear elliptic equations involving multiple critical terms under Dirichlet boundary conditions on bounded smooth domains

Ω
⊂

R

N

(

N
≥
3

)

\Omega \subset {R}^{N}(N\ge 3)

are proved by using the variational method and Pohozaev identity, respectively.
Vibration sensitivity minimization of an ultra-stable optical reference cavity based on orthogonal experimental design
Authors: Gao Jing , Jiao Dongdong , Zhang Linbo , Xu Guanjun , Deng Xue , Zang Qi , Yang Honglei , Dong Ruifang , Liu Tao , Zhang Shougang 
Published: July 2023

Abstract
The ultra-stable optical reference cavity (USORC) is a key element for a variety of applications. In this work, based on the orthogonal experimental design method, we study the vibration sensitivity optimization of a classical USORC with a 100 mm length. According to a test of 4 levels and 3 factors, the L
16 (43) orthogonal table is established to design orthogonal experiments. The vibration sensitivities under different parameters are simulated and analyzed. The vibration sensitivities in three directions of the USORC are used as three single-object values, and the normalized sum of the three vibration sensitivities is selected as comprehensive object values. Through the range analysis of the object values, the influence degrees of the parameters on the three single objects and the comprehensive object are determined. The optimal parameter combination schemes are obtained by using the comprehensive balance method and the comprehensive evaluation method, respectively. Based on the corresponding fractional frequency stability of ultra-stable lasers, the final optimal parameter combination scheme A1B3C3 is determined and verified. This work is the first to use an orthogonal experimental design method to optimize vibration sensitivities, providing an approach to vibration sensitivities optimization and is also beneficial for the vibration sensitivity design of a transportable USORC.
A study on soliton, lump solutions to a generalized (3+1)-dimensional Hirota--Satsuma--Ito equation
Authors: Qi Feng-Hua , Li Zhen-Huan , Li Shuang , Wang Pan 
Published: July 2023

Abstract
In this article, through the Hirota bilinear method and long wave limit method, based on the N-solitons, we construct the multiple lump solutions of the generalized (3+1)-dimensional Hirota–Satsuma–Ito equation. Furthermore, to enhance our understanding of the solutions obtained, we further elucidate the physical implications of these solutions with three-dimensional and two-dimensional graphs. The solutions obtained might have practical applications in elucidating the dynamic behaviors of higher-dimensional systems, particularly in the study area of waves in shallow water and the study of nonlinear optics.
Visual element recognition based on profile coefficient and image processing technology
Authors: Luo Wei 
Published: August 2023

Abstract
A method based on the contour coefficient and image processing technology is proposed to better identify the visual elements. This article takes the contour of the image as the recognition feature, summarizes the methods of target contour feature extraction, contour shape representation, and similarity representation, and studies the processing methods of contour edge preserving and denoising, contour feature simplification and description methods, and contour matching methods. This problem can usually be solved by filling out a form. Generally, a simple iterative equation is given to express the direct relationship between the current table and the calculated table values. The dynamic programming algorithm of inner distance shape context, multi-scale convexity convexity, and triangle area representation finds the best sequence correspondence.
Application of big data technology in electromechanical operation and maintenance intelligent platform
Authors: Yang Wenjuan , Chan Zhongbin , Wang Yi , Qi Fuli 
Published: August 2023

Abstract
Aiming at the data preprocessing requirements and label data cost issues arising from the intelligent operation and maintenance of electromechanical equipment, this article mainly studies structured data cleaning methods and fault prediction algorithms for a small number of label samples. First, this article introduces the overall architecture of the intelligent operation and maintenance system for electromechanical equipment. Second, based on the electromechanical equipment operation and maintenance data access service, data cleaning, and fault prediction, this article constructs an electromechanical equipment intelligent operation and maintenance platform based on Kafka message queue, Spark cluster, and other components, and introduces the functional composition of the system in detail. Finally, the article describes the functions of each component of data access service, data cleaning, and fault prediction in detail. To address the cost issue associated with sufficient labeled sample data for data analysis, we propose a semi-supervised learning algorithm, IF-GBDT, based on improved independent forests and Gradient Boosting Decision Tree. The independent forest algorithm supplements labels for unlabeled data based on the learning results of a small number of labeled samples. We also use the gradient lifting tree algorithm to train the model based on the new tag data set for fault prediction, thereby reducing the impact of lack of tags on the accuracy of the prediction model. Experiments show that this method improves classification accuracy and has good adaptability and concurrency performance for a small number of tags.
A reinforced corrosion assessment method based on a new magnetic sensor and improved adaptive filtering
Authors: Lin Xumei , Zhu Guanghui , Yu Shijie , Wang Peng , Wang Penggang 
Published: August 2023

Abstract
Corrosion assessment of reinforced concrete structures is the basis for subsequent corrosion repair and early warning of structural hazards. Aiming at the problem of accurately measuring the corrosion degree of reinforced concrete structures in coastal area, a new Magnetic Sensor (NMS) based on the theory of magnetic medium is designed in this paper. A functional model of the relationship between magnetic induction intensity change and reinforcement mass loss based on multi-point detection is constructed, and an improved adaptive filtering Least Mean Square (LMS) algorithm is proposed to realize damage identification and quantitative calculation of reinforcement corrosion comprehensively. Through numerical simulation experiments, the feasibility of designing the sensor is verified. The measured corrosion test of the sensor prototype shows that the calculated corrosion rates of different steel corrosion degrees are in good agreement with the actual values, with an average relative error of 1.64 %. The sensor provides a new method for corrosion monitoring of reinforced concrete structures.
Ärztliche Therapieentscheidungsempfeh-lungen in der Onkologie und die Rolle des Personalpronomens wir bei der Aushandlung ärztlicher agency
Authors: Hendricks Dominic , Imo Wolfgang 
Published: August 2023

Abstract
This article focuses on the use of first person plural ‚wir‘ (we) in treatment recommendations. After outlining the research on practices of recommending and decision making in medical interaction as well as the relevance of these practices for therapeutic interventions, we show on the basis of 56 oncological consultations how doctors use ‚wir‘ (we) to encode collective agency (e. g. Enfield 2017) and thus index the recommendations as collectively decided upon by a medical team. Using the methods of Interactional Linguistics (e. g. Imo/Lanwer 2017), we then highlight two different strategies doctors use to account for these recommendations: (i) by explicitly naming the tumor board (and sometimes its members) as the decision-making body and thereby emphasizing the collective expertise of the different specialists who are part of the tumor board or (ii) by grounding the recommendation in the diagnosis itself and thus presenting the therapy as routine treatment to which there is no feasible alternative. Finally, we discuss whether our findings are in line with shared decision making (e. g. Koerfer/Albus 2015), which is often regarded to be the ideal in this context. The article aims to contribute to an empirically grounded description of decision-making processes in medical interaction and the role personal pronouns as markers of agency play in them.
Analysis of the Disc Cutter Cutting Load and Performance during TBM Tunneling in Soft-Hard Varied Strata through Laboratory Cutting Test
Authors: Su Weilin , Niu Fumin , Yang Fengwei , Yang Yi 
Published: July 2023

Abstract
Tunnel boring machine (TBM) disc cutters are specially designed for breaking hard rocks and always exhibit unsatisfactory performance during the soft-hard varied stratum tunneling process. To figure out the load and cutting performance of the disc cutter and avoid unsatisfying excavation face crushing effects, a soft-hard varied strata excavation face model was made and rotary cutting tests with full-scale disc cutters were conducted. The load and cutting performance of the disc cutter under different TBM operating conditions were monitored and analyzed based on the test. It was found that the variation of the disc cutter load did not meet the CSM model completely, and the tangential force of the disc cutters in the heterogeneous areas was only about 30–40 % of that in the uniform areas of the excavation face model. An ideal criterion for the excavation face to be crushed successfully was established and the unknown parameters in it were obtained by fitting the test data. The gradation information and fractal dimension of crushing debris were obtained by the sieved-and-weighed method, which can provide indicators for the crushing effect of the disc cutters. Three different disc cutter poor performance modes in the heterogeneous strata cutting process were analyzed: (1) rotating starting failure of the disc cutters caused by tangential load insufficiency, (2) excavation face crushing failure caused by low crack extending capacities of the materials being cut and improper operating parameters (too small cutting depths or too large disc cutter spacing), and (3) adverse excavation face crushing forms (large or powdery debris). These analyses can help with the performance evaluation of disc cutters and the tunneling parameter adoption of the TBM in soft-hard varied strata tunneling engineering.
Very High Cycle Fatigue Behavior of Additively Manufactured Metals Using Ultrasonic Fatigue Testing: A Critical Assessment of Potentials and Challenges
Authors: Haghshenas Meysam , Simsiriwong Jutima 
Published: July 2023

Abstract
Ultrasonic fatigue testing has been extensively employed to assess the mechanical behavior of most engineering materials in the very high cycle fatigue (VHCF) regime (i.e., the number of cycles to failure beyond 107 cycles). Additionally, with the significant growth of interest in additively manufactured (AM) materials, ultrasonic fatigue testing has increasingly been utilized to evaluate the VHCF performance of various AM metallic materials. In this article, the potential and drawbacks of this testing method for AM metals are presented. Obtaining the ultralong life fatigue behavior in a reasonable time frame (i.e., rapid data generation), assessing the cyclic strain rate (frequency) sensitivity and evaluating the contribution of inevitable AM process-induced defects (i.e., porosity, unmelted powders, lack of fusion, etc.) are considered tangible opportunities in employing ultrasonic fatigue for AM materials. However, lack of test standards, frequency effect for certain material types, and small risk volume of the VHCF specimen that may not be a true representative of AM parts can be considered the main challenges of ultrasonic fatigue testing to obtain the VHCF response of AM metals. This article also reviews several research topics associated with the VHCF of AM metals that can potentially shape the future of research in this field for various applications.
A Dynamic Balance between Neuronal Death and Clearance in anin VitroModel of Acute Brain Injury
Authors: Balena Trevor , Lillis Kyle , Rahmati Negah , Bahari Fatemeh , Dzhala Volodymyr , Berdichevsky Eugene , Staley Kevin 
Published: August 2023

Inin vitromodels of acute brain injury, neuronal death may overwhelm the capacity for microglial phagocytosis, creating a queue of dying neurons awaiting clearance. Neurons undergoing programmed cell death are in this queue, and are the most visible and frequently quantified measure of neuronal death after injury. However, the size of this queue should be equally sensitive to changes in neuronal death and the rate of phagocytosis. Using rodent organotypic hippocampal slice cultures as a model of acute perinatal brain injury, serial imaging demonstrated that the capacity for microglial phagocytosis of dying neurons was overwhelmed for 2 weeks. Altering phagocytosis rates (e.g., by changing the number of microglia) dramatically changed the number of visibly dying neurons. Similar effects were generated when the visibility of dying neurons was altered by changing the membrane permeability for stains that label dying neurons. Canonically neuroprotective interventions, such as seizure blockade, and neurotoxic maneuvers, such as perinatal ethanol exposure, were mediated by effects on microglial activity and the membrane permeability of neurons undergoing programmed cell death. These canonically neuroprotective and neurotoxic interventions had either no or opposing effects on healthy surviving neurons identified by the ongoing expression of transgenic fluorescent proteins.SIGNIFICANCE STATEMENTInin vitromodels of acute brain injury, microglial phagocytosis is overwhelmed by the number of dying cells. Under these conditions, the assumptions on which assays for neuroprotective and neurotoxic effects are based are no longer valid. Thus, longitudinal assays of healthy cells, such as serial assessment of the fluorescence emission of transgenically expressed proteins, provide more accurate estimates of cell death than do single-time point anatomic or biochemical assays of the number of dying neurons. More accurate estimates of death ratesin vitrowill increase the translatability of preclinical studies of neuroprotection and neurotoxicity.
The gravilastic equation and the emergence of gravity waves in large earthquakes
Authors: Lomnitz Cinna 
Published: July 2023

Abstract
Structural collapse on soft ground is one of several emergent effects in the nonlinear complex soil-building system. The gravilastic stress-strain equation is derived from first principles, and we show that it may lead to a phase transition from Rayleigh to gravity waves at large cyclic strains. Instability of high-rise buildings may be caused by a combination of prograde particle motion and short wavelengths. The effect of large amplifications on soft ground may be less critical in terms of damage than is the emergence in specific geological environments of prograde surface waves.
Regional Network focal mechanism determination using 3D velocity model andSH/Pamplitude ratio
Authors: Rau Ruey-Juin , Wu Francis T. , Shin Tzay-Chyn 
Published: July 2023

AbstractHigh-quality focal mechanisms within the Taiwan Seismic Network are determined utilizing first motions, SH/P amplitude ratios, and hypocentral locations obtained in a joint tomographic inversion. The small-to-moderate (2.7 ≦ ML ≦ 5.7) events, ranging in depths from 3 to 43 km, occurred in the area where mountain building is taking place. The data used were recorded between March 1991 and July 1994. Of the 97 earthquakes studied, the focal mechanisms of 23 of these determined on the basis of a 3D velocity model are remarkably different from the routine 1D results. In order to correct for the effect of attenuation on P- and S-wave amplitudes, QP and QS are determined using the spectral ratio method. QP ranges from 289 to 330 and QS from 201 to 301. The SH/P amplitude ratios are found to be very effective as constraints for choosing the best solutions among those consistent with the polarities. The resulting focal mechanisms show a high degree of variability across the island, but in terms of tectonic stress regimes, they show consistent patterns. They provide a glimpse of the mechanical processes under the Taiwan orogen.
Earthquake source spectra in eastern North America
Authors: Haddon R. A. W. 
Published: July 2023

Abstract
A new model for average earthquake S-wave source spectra in eastern North America (ENA) is derived. The model is consistent with fundamental elasto-dynamic principles, as well as the familiar spectral scaling laws appropriate to sources having geometrical and dynamical similarity. Observed characteristics of S-wave spectra in ENA are fully explained as simple consequences of directivity effects entailed by the classical crack rupture model (Kostrov, 1964; Madariaga, 1976), with “normal” effective stresses of the order of 100 bars and fractional stress drop (Brune, 1970): abnormally high stress drops are not required. Recognition of the fundamental role of directivity explains most features of observed data that are currently interpreted as “anomalous”. Among other things, neglect of such effects is shown to be responsible for the conclusion by Boatwright and Choy (1992) and Boore and Atkinson (1992) that high-frequency spectral levels for the magnitude 6 Saguenay earthquake of 1988 are anomalously large. Other important implications of the new model are that some previously inferred systematic variations in Brune stress drop, with magnitude, are simply artifacts of the invalid use of the standard Brune (1970, 1971) model assumption and that current estimates of Q in ENA, which depend on this assumption, are likely to be significantly too large for high frequencies. Associated uncertainties allow the possibility that effective stress does not vary significantly with magnitude, for earthquakes having magnitudes in the range of − 4 to + 7.
The new model suggests that some currently favored source spectra may under-estimate spectral amplitudes of future larger earthquakes in ENA, by as much as a factor of 6, for some frequencies. The proposed new spectra are practically identical with those of the Brune standard model for an effective stress of 100 bars, for frequencies up to about twice the Brune corner frequency, but then increase to values 3 times larger over a range of about 4 in frequency. As such, the high-frequency spectral levels are equivalent to standard Brune model values for earthquakes of one full magnitude unit larger, with consequent important implications for seismic hazard estimates in the region.
Urban seismology—Northridge aftershocks recorded by multi-scale arrays of portable digital seismographs
Authors: Meremonte Mark , Frankel Arthur , Cranswick Edward , Carver David , Worley David 
Published: July 2023

Abstract
We deployed portable digital seismographs in the San Fernando Valley (SFV), the Los Angeles basin (LAB), and surrounding hills to record aftershocks of the 17 January 1994 Northridge California earthquake. The purpose of the deployment was to investigate factors relevant to seismic zonation in urban areas, such as site amplification, sedimentary basin effects, and the variability of ground motion over short baselines. We placed seismographs at 47 sites (not all concurrently) and recorded about 290 earthquakes with magnitudes up to 5.1 at five stations or more. We deployed widely spaced stations for profiles across the San Fernando Valley, as well as five dense arrays (apertures of 200 to 500 m) in areas of high damage, such as the collapsed Interstate 10 overpass, Sherman Oaks, and the collapsed parking garage at CalState Northridge. Aftershock data analysis indicates a correlation of site amplification with mainshock damage. We found several cases where the site amplification depended on the azimuth of the aftershock, possibly indicating focusing from basin structures. For the parking garage array, we found large ground-motion variabilities (a factor of 2) over 200-m distances for sites on the same mapped soil unit. Array analysis of the aftershock seismograms demonstrates that sizable arrivals after the direct S waves consist of surface waves traveling from the same azimuth as that of the epicenter. These surface waves increase the duration of motions and can have frequencies as high as about 4 Hz. For the events studied here, we do not observe large arrivals reflected from the southern edge of the San Fernando Valley.