bluuebunny/crossref_metadata_2025_split huggingface dataset:
The science of child and adolescent mental health in Greece: a nationwide systematic review
Authors: Koumoula Anastasia , Marchionatti Lauro Estivalete , Caye Arthur , Karagiorga Vasiliki Eirini , Balikou Panagiota , Lontou Katerina , Arkoulaki Vicky , Simioni André , Serdari Aspasia , Kotsis Konstantinos , Basta Maria , Kapsimali Efi , Mitropoulou Andromachi , Klavdianou Nikanthi , Zeleni Domna , Mitroulaki Sotiria , Botzaki Anna , Gerostergios Giorgos , Samiotakis Giorgos , Moschos Giorgos , Giannopoulou Ioanna , Papanikolaou Katerina , Aggeli Katerina , Scarmeas Nikolaos , Koulouvaris Panagiotis , Emanuele Jill , Schuster Kenneth , Karyotaki Eirini , Kalikow Lily , Pronoiti Katerina , Gosmann Natan Pereira , Schafer Julia Luiza , Merikangas Kathleen R. , Szatmari Peter , Cuijpers Pim , Georgiades Katholiki , Milham Michael P. , Corcoran Mimi , Burke Sarah , Koplewicz Harold , Salum Giovanni Abrahão 
Published: May 2023

AbstractEvidence-based information is essential for effective mental health care, yet the extent and accessibility of the scientific literature are critical barriers for professionals and policymakers. To map the necessities and make validated resources accessible, we undertook a systematic review of scientific evidence on child and adolescent mental health in Greece encompassing three research topics: prevalence estimates, assessment instruments, and interventions. We searched Pubmed, Web of Science, PsycINFO, Google Scholar, and IATPOTEK from inception to December 16th, 2021. We included studies assessing the prevalence of conditions, reporting data on assessment tools, and experimental interventions. For each area, manuals informed data extraction and the methodological quality were ascertained using validated tools. This review was registered in protocols.io [68583]. We included 104 studies reporting 533 prevalence estimates, 223 studies informing data on 261 assessment instruments, and 34 intervention studies. We report the prevalence of conditions according to regions within the country. A repository of locally validated instruments and their psychometrics was compiled. An overview of interventions provided data on their effectiveness. The outcomes are made available in an interactive resource online [https://rpubs.com/camhi/sysrev_table]. Scientific evidence on child and adolescent mental health in Greece has now been cataloged and appraised. This timely and accessible compendium of up-to-date evidence offers valuable resources for clinical practice and policymaking in Greece and may encourage similar assessments in other countries.
Easy and low-cost transient detection of Al(III) evolution during the galvanic corrosion of aluminum alloys
Authors: Esquivel-Peña V. , Ruiz-García A. , Genescá J. , Montoya R. 
Published: May 2023

AbstractCorrosion is a serious problem that affects several industries and causes significant economic losses. In recent years, the transportation industry has replaced several ferrous parts with aluminum or magnesium alloys to produce lighter vehicles. Due to this, galvanic corrosion has been more frequent in that industry. In this work, a colorimetric sensor for the detection of Al(III) species during galvanic corrosion is presented. The sensor was made of a chromophore immobilized on a gel electrolyte based on NaCl and agar. The sensor developed a red coloration proportional to the Al(III) concentration under the pH interval studied (3.2–4.5). A galvanic couple consisting of an aluminum alloy and carbon steel was used to test the capacity of the sensor to develop the production of Al(III) into the gel electrolyte and over the whole aluminum surface. Through image processing, it was possible to construct 2D Al(III) concentration maps over time using a commercial aluminum alloy (AA7075) and a castable aluminum alloy from a steering rack as a real sample.
Graphical Abstract
Spatial networks and the spread of COVID-19: results and policy implications from Germany
Authors: Flückiger Matthias , Ludwig Markus 
Published: May 2023

AbstractSpatial networks are known to be informative about the spatiotemporal transmission dynamics of COVID-19. Using district-level panel data from Germany that cover the first 22 weeks of 2020, we show that mobility, commuter and social networks all predict the spatiotemporal propagation of the epidemic. The main innovation of our approach is that it incorporates the whole network and updated information on case numbers across districts over time. We find that when disease incidence increases in network neighbouring regions, case numbers in the home district surge one week later. The magnitude of these network transmission effects is comparable to within-district transmission, illustrating the importance of networks as drivers of local disease dynamics. After the introduction of containment policies in mid-March, network transmission intensity drops substantially. Our analysis suggests that this reduction is primarily due to a change in quality—not quantity—of interregional movements. This implies that blanket mobility restrictions are not a prerequisite for containing the interregional spread of COVID-19.
Sex differences in social buffering and social contagion of alarm responses in zebrafish
Authors: Akinrinade Ibukun D. , Varela Susana A. M. , Oliveira Rui F. 
Published: May 2023

AbstractThe alarm substance in fish is a pheromone released by injured individuals after a predator attack. When detected by other fish, it triggers fear/defensive responses, such as freezing and erratic movement behaviours. Such responses can also help other fish in the shoal to modulate their own behaviours: decreasing a fear response if conspecifics have not detected the alarm substance (social buffering) or triggering a fear response if conspecifics detected the alarm substance (social contagion). Response variation to these social phenomena is likely to depend on sex. Because males have higher-risk life-history strategies than females, they may respond more to social buffering where they risk not responding to a real predator attack, while females should respond more to social contagion because they only risk responding to a false alarm. Using zebrafish, we explored how the response of males and females to the presence/absence of the alarm substance is modified by the alarmed/unalarmed behaviour of an adjacent shoal of conspecifics. We found that, in social buffering, males decreased freezing more than females as expected, but in social contagion males also responded more than females by freezing at a higher intensity. Males were, therefore, more sensitive to visual information, while females responded more to the alarm substance itself. Because visual information updates faster than chemical information, males took more risks but potentially more benefits as well, because a quicker adjustment of a fear response allows to save energy to other activities. These sex differences provide insight into the modifying effect of life-history strategies on the use of social information.
The impact of preoperative sarcopenia on postoperative ileus following colorectal cancer surgery
Authors: Traeger L. , Bedrikovetski S. , Nguyen TM. , Kwan Y. X. , Lewis M. , Moore J. W. , Sammour T. 
Published: May 2023

Abstract
Purpose
Sarcopenia is associated with poor short- and long-term patient outcomes following colorectal surgery. Despite postoperative ileus (POI) being a major complication following colorectal surgery, the predictive value of sarcopenia for POI is unclear. We assessed the association between sarcopenia and POI in patients with colorectal cancer.

Methods
Elective colorectal cancer surgery patients were retrospectively included (2018–2022). The cross-sectional psoas area was calculated using preoperative staging imaging at the level of the 3rd lumbar vertebrae. Sarcopenia was determined using gender-specific cut-offs. The primary outcome POI was defined as not achieving GI-2 by day 4. Demographics, operative characteristics, and complications were compared via univariate and multivariate analyses.

Results
Of 297 patients, 67 (22.6%) were sarcopenic. Patients with sarcopenia were older (median 74 (IQR 67–82) vs. 69 (58–76) years, p < 0.001) and had lower body mass index (median 24.4 (IQR 22.2–28.6) vs. 28.8 (24.9–31.9) kg/m2, p < 0.001). POI was significantly more prevalent in patients with sarcopenia (41.8% vs. 26.5%, p = 0.016). Overall rate of complications (85.1% vs. 68.3%, p = 0.007), Calvien-Dindo grade > 3 (13.4% vs. 10.0%, p = 0.026) and length of stay were increased in patients with sarcopenia (median 7 (IQR 5–12) vs. 6 (4–8) days, p = 0.013). Anastomotic leak rate was higher in patients with sarcopenia although the difference was not statistically significant (7.5% vs. 2.6%, p = 0.064). Multivariate analysis demonstrated sarcopenia (OR 2.0, 95% CI 1.1–3.8), male sex (OR 1.9, 95% CI 1.0–3.5), postoperative hypokalemia (OR 3.2, 95% CI 1.6–6.5) and increased opioid use (OR 2.4, 95% CI 1.3–4.3) were predictive of POI.

Conclusion
Sarcopenia demonstrates an association with POI. Future research towards truly identifying the predictive value of sarcopenia for postoperative complications could improve informed consent and operative planning for surgical patients.
A bilevel approach to ESG multi-portfolio selection
Authors: Cesarone Francesco , Lampariello Lorenzo , Merolla Davide , Ricci Jacopo Maria , Sagratella Simone , Sasso Valerio Giuseppe 
Published: May 2023

AbstractWe rely on bilevel programming to model the problem of financial service providers that, in order to meet stakeholders’ demands and regulatory requirements, aim at incentivizing accounts’ holders to construct ESG-oriented portfolios so that the overall ESG impact of the firm is optimized, while the preferences of accounts’ owners are still satisfied. We analyze this complicated framework from a theoretical point of view and identify sufficient conditions that make it numerically tractable via a novel, specifically tailored algorithm, whose convergence properties are studied. Numerical testing on real-world data confirms the theoretical insights and shows that our model can be solved even when dealing with considerable problem sizes.
Similar growth responses to climatic variations in Norway spruce (Picea abies) and European beech (Fagus sylvatica) at the northern range limit of beech
Authors: Lie Marit H. , Asplund Johan , Göhl Matthias , Ohlson Mikael , Nybakken Line 
Published: May 2023

AbstractIn south-east Norway, in the hemiboreal vegetation zone, beech reaches its northern distribution limit and typically occupies the same type of sites as spruce. Under future climate change, this area is projected to fall within the temperate zone and beech to increase its distribution towards the north at the expense of spruce. However, such forecasts are based on very broad scale estimates and the knowledge of climatic adaptation and the competitive potential of the beech and spruce populations at these latitudes is scarce. Here, we use a dendrochronological approach to study the growth performance of neighbouring spruce and beech trees to climate variability over a period of 70 years. The two species responded quite similarly to variations in climate in the study area. Both showed increased incremental growth in response to high precipitation both in the previous and present year June, indicating that water is a limiting resource. In addition, beech showed a negative response to high temperatures in previous July and August, which is probably connected with growth reductions due to masting. Overall, spruce and beech in the hemiboreal zone show comparable responses to climatic variations as in the temperate zone. Due to the different drought-handling strategies of the two species, we suggest that the intensity of summer droughts and the variability between years are likely factors that would be decisive for which of them that will be more successful under future climatic conditions.
The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action
Authors: Morsy Hadeer M. , Ahmed Osama M. , Zoheir Khairy M. A. , Abdel-Moneim Adel 
Published: May 2023

AbstractThis study was designed to assess the ameliorative effects of eugenol and to propose the possible mechanisms of action of eugenol in diethylnitrosamine (DENA)/acetylaminofluorene (AAF)-caused lung cancer in Wistar rats. To induce lung cancer, DENA at a dose of 150 mg/kg body weight (b.wt) for 2 weeks were intraperitoneally injected once each week and AAF was administered orally at a dose of 20 mg/kg b.wt. four times each week for the next 3 weeks. DENA/AAF-administered rats were orally supplemented with eugenol at a dose of 20 mg/kg b.wt administered once a day until 17 weeks starting from the 1st week of DENA administration. Lung histological lesions, including sheets of tumor cells, micropapillary adenocarcinoma, and apoptotic cells, resulting from the DENA/AAF dosage, were ameliorated by eugenol treatment. However, a significant drop in the levels of LPO in the lungs and a remarkable rise in GSH content and GPx and SOD activities were observed in DENA/AAF-administered rats treated with eugenol compared with those in DENA/AAF-administered controls. Moreover, in DENA/AAF-administered rats, eugenol supplementation significantly reduced TNF-α and IL-1β levels and mRNA expression levels of NF-κB, NF-κB p65, and MCP-1 but significantly elevated the level of Nrf2. Furthermore, the DENA/AAF-administered rats treated with eugenol exhibited a significant downregulation of Bcl-2 expression levels in addition to a significant upregulation in P53 and Bax expression levels. Otherwise, the administration of DENA/AAF elevated the protein expression level of Ki-67, and this elevation was reversed by eugenol treatment. In conclusion, eugenol has effective antioxidant, anti-inflammatory, proapoptotic, and antiproliferative properties against lung cancer.
Graphical abstract
Terahertz Beam Steering with Curved Metasurfaces
Authors: Shiri Yaseman , Guerboukha Hichem , Mittleman Daniel M. 
Published: May 2023

AbstractConsiderable recent research interest has focused on the possibility of using metasurfaces for manipulation of terahertz wavefronts. For example, metasurfaces allow a beam to be targeted in any desired direction using strategically placed meta-elements. With rapid prototyping techniques, metasurfaces can be fabricated quickly and at a low cost. These techniques also permit the fabrication of metasurfaces on flexible substrates which can be bent easily. This opens the possibility of employing such devices as conformable arrays on non-flat surfaces. To explore this idea, we experimentally and numerically analyze the performance of a terahertz metasurface printed on paper, as a function of its radius of curvature. We observe that when the metasurface is bent, the direction of the refracted beam is minimally impacted and the performance of the metasurface remains very similar to when it is flat. This conclusion will simplify the design and modeling criteria for conformable metasurfaces.
Optimisation of Pharmaceutical Cocrystal Dissolution Performance through a Synergistic Precipitation Inhibition
Authors: Shi Kejing , Li Mingzhong 
Published: May 2023

Abstract
Objectives
Polymeric excipients play an important role in a cocrystal formulation to act as precipitation inhibitors to maximize the potential. Otherwise, a stable form of the parent drug will be recrystallized on the dissolving cocrystal surface and/or in the bulk solution during the cocrystal dissolution process, negating the solubility advantage. The objectives of this work were to investigate the potential of using combined polymers to maximise the dissolution performance of surface precipitation pharmaceutical cocrystals.

Methods
The dissolution performance of a highly soluble flufenamic acid and nicotinamide (FFA-NIC) cocrystal has been systematically studied with predissolved or powder mixed with a single polymer, including a surface precipitation inhibitor [i.e., copolymer of vinylpyrrolidone (60%) /vinyl acetate (40%) (PVP-VA)] and two bulk precipitation inhibitors [i.e., polyethylene glycol (PEG) and Soluplus (SLP)], or binary polymers combinations.

Results
A single polymer of PVP-VA prevented the FFA surface precipitation for an enhanced dissolution performance of FFA-NIC cocrystal. Unfortunately, it cannot sustain the supersaturated FFA concentration in the bulk solution. A combination of two polymers of PVP-VA and SLP has shown a synergistic inhibition effect to enhance the dissolution advantage of FFA-NIC cocrystal.

Conclusions
The dissolution of a cocrystal with surface precipitation of the parent drug can be described as: i) the cocrystal surface contacting the dissolution medium; ii) the cocrystal surface dissolving; iii) the parent drug precipitation on the dissolving surface; and iv) the parent drug particles redissolving. A combination of two types of polymers can be used to maximise the cocrystal performance in solution.

Graphical Abstract
Cross-cultural differences in retracted publications of male and female from a global perspective
Authors: Li Shenghui , Xu Wenyan , Yin Jingqi 
Published: May 2023

AbstractThe aim of this paper is threefold: (i) to identify the combinations of national culture dimensions that lead to high (or low) male or female retracted publications, (ii) to understand the role of personal trust as a relevant condition that combines with national culture dimensions to cause high (or low) male or female retraction, and (iii) to identify the differences in the configurations that lead to those outcomes. Based on framework of Hofstede's cross-cultural analysis and data from Hofstede Center, World Value, and Web of Science, this essay analyzes cultural complex causal relations between national culture and trust dimensions (conditions), and male and female retracted publications (outcomes) in 30 countries nationally and globally by fuzzy-set qualitative comparative analysis. This research provides three major insights: (i) Cultural dimensions (power distance, individualism, masculinity, uncertainty avoidance, long-term orientation) and trust are not necessary conditions for both male and female to cause retractions, (ii) different levels of personal trust (high/low) combine with national cultural dimensions in order to produce different configurations that can lead to high or low retractions, and (iii) Each gender causes retractions in a similar or identical way, but each also owns its unique way. Finally, we provide effective policy recommendations to specific countries based on our critical conclusions and discussions.
Preparation and characterization of chemically cross-linked zwitterionic copolymer hydrogel for direct dye and toxic trace metal removal from aqueous medium
Authors: Koryam Asmaa A. , El-Wakeel Shaimaa T. , Radwan Emad K. , Fattah Azza M. Abdel , Darwish Elham S. 
Published: May 2023

AbstractIn this work, a zwitterionic copolymer hydrogel with adsorption affinity toward anionic dye and cationic trace metal was prepared by a free radical copolymerization of cationic ([3-(methacryloylamino)propyl] trimethylammonium chloride (MPTC)) and anionic (sodium 4-vinylbenzenesulfonate (SVBS)) monomers. Bis[2-(methacryloyloxy)ethyl] phosphate was used as a cross-linker and its effect on the adsorption properties of the prepared hydrogel was evaluated. The prepared materials were characterized by FTIR, XRD, SEM, EDX, and N2 adsorption at 77 K analysis. FTIR and EDX analysis demonstrated the successful preparation of poly(MPTC-co-VBS). XRD and SEM analysis showed that the poly (MPTC-co-VBS) is amorphous and has quasi-honeycomb morphology with large pores. Increasing the amount of the cross-linker enhanced the adsorption of direct blue 71 dye (DB71) and Pb(II) ions. The highest removal of DB71 and Pb(II) was achieved after 2 h using 1.5 g/L of poly(MPTC-co-VBS); however, the optimum solution pH was 3 for DB71 and 5 for Pb(II). The kinetics and isotherm studies illustrated that the surface of poly(MPTC-co-VBS) is heterogenous with small-sized homogenous pitches and the DB71 and Pb(II) adsorption onto poly(MPTC-co-VBS) is favorable. Finally, poly(MPTC-co-VBS) is more efficient in removing DB71 and Pb(II) from aqueous solutions than many other reported adsorbents.
Tumor infiltrating lymphocytes and radiological picture of the tumor
Authors: Frankowska Karolina , Zarobkiewicz Michał , Dąbrowska Izabela , Bojarska-Junak Agnieszka 
Published: May 2023

AbstractTumor microenvironment (TME) is a complex entity that includes besides the tumor cells also a whole range of immune cells. Among various populations of immune cells infiltrating the tumor, tumor infiltrating lymphocytes (TILs) are a population of lymphocytes characterized by high reactivity against the tumor component. As, TILs play a key role in mediating responses to several types of therapy and significantly improve patient outcomes in some cancer types including for instance breast cancer and lung cancer, their assessment has become a good predictive tool in the evaluation of potential treatment efficacy. Currently, the evaluation of the density of TILs infiltration is performed by histopathological. However, recent studies have shed light on potential utility of several imaging methods, including ultrasonography, magnetic resonance imaging (MRI), positron emission tomography-computed tomography (PET-CT), and radiomics, in the assessment of TILs levels. The greatest attention concerning the utility of radiology methods is directed to breast and lung cancers, nevertheless imaging methods of TILs are constantly being developed also for other malignancies. Here, we focus on reviewing the radiological methods used to assess the level of TILs in different cancer types and on the extraction of the most favorable radiological features assessed by each method.
Palmitic Acid Upregulates Type I Interferon–Mediated Antiviral Response and Cholesterol Biosynthesis in Human Astrocytes
Authors: Rojas-Cruz Alexis Felipe , Martín-Jiménez Cynthia Alexandra , González Janneth , González-Giraldo Yeimy , Pinzón Andrés Mauricio , Barreto George E. , Aristizábal-Pachón Andrés Felipe 
Published: May 2023

AbstractChronic intake of a high-fat diet increases saturated fatty acids in the brain causing the progression of neurodegenerative diseases. Palmitic acid is a free fatty acid abundant in the diet that at high concentrations may penetrate the blood–brain barrier and stimulate the production of pro-inflammatory cytokines, leading to inflammation in astrocytes. The use of the synthetic neurosteroid tibolone in protection against fatty acid toxicity is emerging, but its transcriptional effects on palmitic acid–induced lipotoxicity remain unclear. Herein, we performed a transcriptome profiling of normal human astrocytes to investigate the molecular mechanisms by which palmitic acid causes cellular damage to astrocytes, and whether tibolone could reverse its detrimental effects. Astrocytes undergo a profound transcriptional change at 2 mM palmitic acid, affecting the expression of 739 genes, 366 upregulated and 373 downregulated. However, tibolone at 10 nM does not entirely reverse palmitic acid effects. Additionally, the protein–protein interaction reveals two novel gene clustering modules. The first module involves astrocyte defense responses by upregulation of pathways associated with antiviral innate immunity, and the second is linked to lipid metabolism. Our data suggest that activation of viral response signaling pathways might be so far, the initial molecular mechanism of astrocytes in response to a lipotoxic insult by palmitic acid, triggered particularly upon increased expression levels of IFIT2, IRF1, and XAF1. Therefore, this novel approach using a global gene expression analysis may shed light on the pleiotropic effects of palmitic acid on astrocytes, and provide a basis for future studies addressed to elucidate these responses in neurodegenerative conditions, which is highly valuable for the design of therapeutic strategies.