bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conformation Dependent Architectures of Assembled Antimicrobial Peptides with Enhanced Antimicrobial Ability
Authors: Lan Xinmiao , Zhong Jie , Huang Regina , Liu Yuhan , Ma Xiaowei , Li Xuan , Zhao Dan , Qing Guangchao , Zhang Yuxuan , Liu Lu , Wang Jinjin , Ma Xu , Luo Ting , Guo Weisheng , Wang Yuji , Li Li‐Li , Su Yu‐Xiong , Liang Xing‐Jie 
Published: August 2023

AbstractAntimicrobial peptides (AMPs) are a developing class of natural and synthetic oligopeptides with host defense mechanisms against a broad spectrum of microorganisms. With in‐depth research on the structural conformations of AMPs, synthesis or modification of peptides has shown great potential in effectively obtaining new therapeutic agents with improved physicochemical and biological properties. Notably, AMPs with self‐assembled properties have gradually become a hot research topic for various biomedical applications. Compared to monomeric peptides, these peptides can exist in diverse forms (e.g., nanoparticles, nanorods, and nanofibers) and possess several advantages, such as high stability, good biocompatibility, and potent biological functions, after forming aggregates under specific conditions. In particular, the stability and antibacterial property of these AMPs can be modulated by rationally regulating the peptide sequences to promote self‐assembly, leading to the reconstruction of molecular structure and spatial orientation while introducing some peptide fragments into the scaffolds. In this work, four self‐assembled AMPs are developed, and the relationship between their chemical structures and antibacterial activity is explored extensively through different experiments. Importantly, the evaluation of antibacterial performance in both in vitro and in vivo studies has provided a general guide for using self‐assembled AMPs in subsequent treatments for combating bacterial infections.
Spiral‐Structured Dielectric Polymers Exhibiting Ultrahigh Energy Density and Charge–Discharge Efficiency at High Temperatures
Authors: Ran Zhaoyu , Wang Rui , Fu Jing , Yang Mingcong , Li Manxi , Hu Jun , He Jinliang , Li Qi 
Published: August 2023

AbstractThe growing need for high‐power and compact‐size energy storage in modern electronic and electrical systems demands polymer film capacitors with excellent temperature capability. However, conventional polymer dielectrics feature dramatic deterioration in capacitive performance under concurrent high temperature and electric field because the high thermal stability traditionally relies on the conjugated, planar molecular segments in the polymer chains. Herein, inspired by the stable double helix structures of deoxyribonucleic acid, spiral‐structured dielectric polymers that exhibit simultaneous high thermal stability and great capacitive performance are demonstrated. Both the experimental results and computational simulations confirm that the spiral groups serve to weaken the electrostatic molecular interaction, induce proper molecular chain stacking structure, and regulate the charge transfer process by breaking the conjugated planes and introducing deep trap sites. The resultant polymer exhibits the maximum discharged energy densities of 7.29 and 6.13 J cm−3 with the charge–discharge efficiency above 90% at 150 and 200 °C, respectively, more than ten times those of the original dielectric at the same conditions. Here a completely new dimension is offered for the molecular design of polymers, giving rise to well‐balanced thermal and dielectric properties, and ultimately the desired capacitive energy storage performance at high temperatures.
AIEgen‐Based Covalent Organic Frameworks for Preventing Malignant Ventricular Arrhythmias Via Local Hyperthermia Therapy
Authors: Zhang Liang , Guo Fuding , Xu Saiting , Deng Qiang , Xie Mengjie , Sun Jianwei , Kwok Ryan T. K. , Lam Jacky W. Y. , Deng Hexiang , Jiang Hong , Yu Lilei , Tang Ben Zhong 
Published: August 2023

AbstractThe engineering of aggregation‐induced emission luminogens (AIEgen) based covalent organic frameworks (COFs), TDTA‐COF, BTDTA‐COF, and BTDBETA‐COF are reported, as hyperthermia agents for inhibiting the occurrence of malignant ventricular arrhythmias (VAs). These AIE COFs exhibit dual functionality, as they not only directly modulate the function and neural activity of stellate ganglion (SG) through local hyperthermia therapy (LHT) but also induce the browning of white fat and improve the neuroinflammation peri‐SG microenvironment, which is favorable for inhibiting ischemia‐induced VAs. In vivo studies have confirmed that BTDBETA‐COF‐mediated LHT enhances thermogenesis and browning‐related gene expression, thereby serving a synergistic role in combating VAs. Transcriptome analysis of peri‐SG adipose tissue reveals a substantial downregulation of inflammatory cytokines, highlighting the potency of BTDBETA‐COF‐mediated LHT in ameliorating the neuroinflammation peri‐SG microenvironment and offering myocardial and arrhythmia protection. The work on AIE COF‐based hyperthermia agent for VAs inhibition provides a new avenue for mitigating cardiac sympathetic nerve hyperactivity.
Regulating Phase Separation Kinetics for High‐Efficiency and Mechanically Robust All‐Polymer Solar Cells
Authors: Wang Jianqiu , Wang Yafei , Xian Kaihu , Qiao Jiawei , Chen Zhihao , Bi Pengqing , Zhang Tao , Zheng Zhong , Hao Xiaotao , Ye Long , Zhang Shaoqing , Hou Jianhui 
Published: August 2023

AbstractAll‐polymer solar cells (all‐PSCs) possess excellent operation stability and mechanical robustness than other types of organic solar cells, thereby attracting considerable attention for wearable flexible electron devices. However, the power conversion efficiencies (PCEs) of all‐PSCs are still lagging behind those of small‐molecule‐acceptor‐based systems owing to the limitation of photoactive materials and unsatisfactory blend morphology. In this work, a novel terpolymer, denoted as PBDB‐TFCl (poly4,8‐bis(5‐(2‐ethylhexyl)‐4‐fluorothiophen‐2‐yl)benzo[1,2‐b:4,5‐b″]dithiophene‐1,3‐bis(2‐ethylhexyl)‐5,7‐di(thiophen‐2‐yl)‐4H,8H‐benzo[1,2‐c:4,5‐c″]dithiophene‐4,8‐dione‐4,8‐bis(4‐chloro‐5‐(2‐ethylhexyl)thiophen‐2‐yl)benzo[1,2‐b:4,5‐b′]dithiophene), is used as an electron donor coupled with a ternary strategy to optimize the performance of all‐PSCs. The addition of PBDB‐TCl unit deepens the highest occupied molecular orbital energy level, reducing voltage losses. Moreover, the introduction of the guest donor (D18‐Cl) effectively regulates the phase‐transition kinetics of PBDB‐TFCl:D18‐Cl:PY‐IT during the film formation, leading to ideal size of aggregations and enhanced crystallinity. PBDB‐TFCl:D18‐Cl:PY‐IT devices exhibit a PCE of 18.6% (certified as 18.3%), judged as the highest value so far obtained with all‐PSCs. Besides, based on the ternary active layer, the manufactured 36 cm2 flexible modules exhibit a PCE of 15.1%. Meanwhile, the ternary PSCs exhibit superior photostability and mechanical stability. In summary, the proposed strategy, based on molecular design and the ternary strategy, allows optimization of the all‐polymer blend morphology and improvement of the photovoltaic performance for stable large‐scale flexible PSCs.
Sprayable Thermoset Nanocomposite Coatings Based on Silanized‐PEG/ZnO to Prevent Microbial Infections of Titanium Implants
Authors: Morselli Davide , Iseppi Ramona , Papadopoulou Evie L. , Bolelli Giovanni , Sabia Carla , Degli Esposti Micaela , Fabbri Paola 
Published: August 2023

AbstractPost‐surgery microbial infections are still one of the main reasons for implant failure, which results in very high physical and psychological pain for the patient and an increased cost for the healthcare system. A polymer nanocomposite antibacterial coating on titanium implants represents a valuable alternative to the more expensive and energy‐consuming technological solutions nowadays used. In this regard, a sprayable thermoset nanocomposite composed of silanized‐terminals polyethylene glycol (PEG)/ZnO nanoparticle is herein proposed. Initially, PEG's terminals' solvent‐free silanization and curing are studied by Fourier Transform Infrared and µRaman spectroscopies. Scanning Electron Microscope investigations and scratch tests have shown that the spraying procedure optimization and the oxidation treatment of the titanium substrate lead to a homogeneous coverage and improved adhesion of the coatings. The antibacterial activity is tested against not only both S. aureus and P. aeruginosa bacterial American Type Culture Collection strains, but also using very aggressive antibiotic‐resistant clinical strains. Interestingly, antibacterial activity, evaluated by time‐killing tests, is observed for all tested bacterial strains. Live/dead tests further confirm that 5 wt% of ZnO allows obtaining a bacteriostatic activity within 24 h, whereas a complete growth inhibition (bactericidal activity) of both tested strains is observed for coatings with 20 wt% of ZnO nanoparticles.
Tunable Excitation Polarized Upconversion Luminescence and Reconfigurable Double Anti‐Counterfeiting from Er3+ Doped Single Nanorods
Authors: Wen Dongping , Zuo Shanling , Huang Chunfeng , Tan Zongqian , Lu Fuxi , Liang Yi , Mo Xiaoming , Lin Tao , Cao Sheng , Qiu Jianrong , Zhao Jialong , Chen Ping 
Published: August 2023

AbstractExcitation polarized upconversion luminescence (EPUL) from lanthanide ions has attracted considerable attention due to its wide applications in microfluidics, single particle tracking, security inks, and cell internal viscosity testing. However, controlling the degree of excitation polarization (DOEP) of the EPUL remains a significant challenge. Here, the modulation of the DOEP (from 0 to 0.5) of the EPUL from Er3+ doped single nanorods by changing the concentration of doped Er3+, Yb3+, or Mn2+ is systematically studied. By analyzing the lifetimes and disproportionate changes in luminescence intensities, it is found that optimizing Er3+, Yb3+, or Mn2+ concentration can reduce non‐radiative transition and population density in excited states, leading to the enhancement of the DOEP under a good alignment of transition dipoles. Furthermore, the possibility of anti‐counterfeiting based on such tunable EPUL is illustrated. Three kinds of fine patterns with a small size of 10 µm are realized by assembling the single nanorods accurately via optical tweezers. The patterns and their EPUL guarantee double protection for the feasibility of anti‐counterfeiting. The findings of this study offer insights into the EPUL from lanthanide ions and provide a microscale platform via the EPUL for the application of multidimensional information encoding and reconfigurable double anti‐counterfeiting.
Cation‐Radius‐Controlled Sn−O Bond Length Boosting CO2 Electroreduction over Sn‐Based Perovskite Oxides
Authors: Chen Mingfa , Chang Kuan , Zhang Yu , Zhang Zhenbao , Dong Yuming , Qiu Xiaoyu , Jiang Heqing , Zhu Yongfa , Zhu Jiawei 
Published: August 2023

AbstractDespite the intriguing potential shown by Sn‐based perovskite oxides in CO2 electroreduction (CO2RR), the rational optimization of their CO2RR properties is still lacking. Here we report an effective strategy to promote CO2‐to‐HCOOH conversion of Sn‐based perovskite oxides by A‐site‐radius‐controlled Sn−O bond lengths. For the proof‐of‐concept examples of Ba1−xSrxSnO3, as the A‐site cation average radii decrease from 1.61 to 1.44 Å, their Sn−O bonds are precisely shortened from 2.06 to 2.02 Å. Our CO2RR measurements show that the activity and selectivity of these samples for HCOOH production exhibit volcano‐type trends with the Sn−O bond lengths. Among these samples, the Ba0.5Sr0.5SnO3 features the optimal activity (753.6 mA ⋅ cm−2) and selectivity (90.9 %) for HCOOH, better than those of the reported Sn‐based oxides. Such optimized CO2RR properties could be attributed to favorable merits conferred by the precisely controlled Sn−O bond lengths, e.g., the regulated band center, modulated adsorption/activation of intermediates, and reduced energy barrier for *OCHO formation. This work brings a new avenue for rational design of advanced Sn‐based perovskite oxides toward CO2RR.
Die Elektrokatalyse der Wasserstoffentwicklung im Sauren an Hochentropielegierungen korreliert mit dem von der Zusammensetzung abhängigen Nullladungspotential
Authors: Kim Moonjoo , Batsa Tetteh Emmanuel , Krysiak Olga A. , Savan Alan , Xiao Bin , Piotrowiak Tobias Horst , Andronescu Corina , Ludwig Alfred , Dong Chung Taek , Schuhmann Wolfgang 
Published: August 2023

AbstractAufgrund der enormen Variation möglicher Elementkombinationen von Hochentropielegierungen (HEAs) ist es von entscheidender Bedeutung, Aktivitätsdeskriptoren zu finden, um rationale Prinzipien für die Entwicklung von Elektrokatalysatoren zu entwickeln. Trotz der zunehmenden Beachtung des Nullladungspotentials (PZC) bei Elektrokatalysatoren für die Wasserstoffevolutionsreaktion (HER), wurden weder das PZC von HEAs noch die Auswirkungen des PZC auf die HER‐Aktivität bei HEAs beschrieben. Hier verwenden wir die rasterelektrochemische Zellmikroskopie (SECCM), um das PZC und die HER‐Aktivitäten verschiedener Elementzusammensetzungen einer Pt−Pd−Ru−Ir−Ag‐Dünnfilm‐HEA‐Materialbibliothek (HEA‐ML) mit hoher statistischer Zuverlässigkeit zu bestimmen. Interessanterweise ist das PZC von Pt−Pd−Ru−Ir−Ag linear mit seiner zusammensetzungsgewichteten durchschnittlichen Austrittsarbeit korreliert. Die HER‐Stromdichte in sauren Medien korreliert positiv mit dem PZC, was durch die Anreicherung von H+ in der elektrochemischen Doppelschicht bei negativen Potentialen relativ zum PZC erklärt werden kann.
Effectiveness of physical activity interventions for core symptoms of autism spectrum disorder: A systematic review and meta‐analysis
Authors: Wang Shimeng , Chen Dandan , Yang Yang , Zhu Lina , Xiong Xuan , Chen Aiguo 
Published: August 2023

AbstractIn this paper, systematic review and meta‐analysis were used to demonstrate the effectiveness of physical activity intervention on core symptoms of autism spectrum disorder (ASD). Physical activity intervention for core symptoms of ASD were retrieved by computer from the PubMed Cochrane Library, Web of Science, APA PsycNet, and CNKI database during December 1, 2022. Two researchers evaluated the quality of the included literature and extracted the data. Sixteen studies were eventually included, with a total of 587 patients with ASD. Meta‐analysis showed that the core symptoms of ASD patients decreased after physical activity intervention, ES(g) = 0.681(95% CI: 0.380–0.982, p = 0.000), specifically, physical activity improved the reduction of social disorder ES(g) = 0.749(95% CI: 0.524–0.973) and repeated rigid behavior ES(g) = 0.553 (95% CI: −0.079 to 1.186). Subgroup analysis showed that preschool children with ASD who were 3–6 years old, exercised for more than 12 weeks, more than 3 times a week, and exercised for more than 90 min per session had better improvement in core symptoms after participating in physical activity. The conclusion of this paper is that physical activity intervention can improve the core symptoms of ASD, especially the reduction of social disorders and repetitive behaviors.
Carbon‐Coated NaVPO4F as a High‐Capacity Cathode for Aqueous Sodium‐Ion Battery
Authors: Wang Yanrong , Bin Duan , Wang Caixing , Cao Yongjie , Xia Yongyao 
Published: August 2023

AbstractNaVPO4F has garnered significant attention as a promising cathode material for non‐aqueous sodium‐ion batteries due to its high theoretical specific capacity and appropriate potential. However, the dissolution of vanadium component of NaVPO4F in aqueous electrolytes has restricted its application in aqueous sodium‐ion batteries (ASIBs). Herein, we report the use of carbon‐coated NaVPO4F as a cathode material in ASIBs. This cathode material exhibited a discharge capacity of 111 mAh g−1 at 0.5 A g−1 in a concentrated 17 m NaClO4 aqueous solution and demonstrated capacity retention of 74.4 % over 100 cycles. The experimental results confirmed that the carbon coating on NaVPO4F and high‐concentration NaClO4 aqueous electrolyte exhibited positive effects in restraining vanadium dissolution. Additionally, when configuration with NaTi2(PO4)3@C as anode, the full cell exhibited a capacity of 43.9 mAh g−1 with an average operating voltage of 1.2 V at a current density of 0.5 A g−1 in a concentrated 17 m NaClO4 aqueous electrolyte. These outcomes underscore the potential of NaVPO4F@C as a promising cathode material for ASIBs.
Dose–response analysis after administration of a human platelet‐derived exosome product on neurite outgrowth in vitro
Authors: Saffari Sara , Rademakers Daan J. , Pulos Nicholas , Shin Alexander Y. 
Published: August 2023

AbstractModulating the nerve's local microenvironment using exosomes is proposed to enhance nerve regeneration. This study aimed to determine the optimal dose of purified exosome product (PEP) required to exert maximal neurite extension. An in vitro dorsal root ganglion (DRG) neurite outgrowth assay was used to evaluate the effect of treatment with (i) 5% PEP, (ii) 10% PEP, (iii) 15% PEP, or (iv) 20% PEP on neurite extension (N = 9/group), compared to untreated controls. After 72 h, neurite extension was measured to quantify nerve regeneration. Live cell imaging was used to visualize neurite outgrowth during incubation. Treatment with 5% PEP resulted in the longest neurite extension and was superior to the untreated DRG (p = 0.003). Treatment with 10% PEP, 15% PEP, and 20% PEP was found to be comparable to controls (p = 0.12, p = 0.06, and p = 0.41, respectively) and each other. Live cell imaging suggested that PEP migrated towards the DRG neural regeneration site, compared to the persistent homogenous distribution of PEP in culture media alone. 5% PEP was found to be the optimal concentration for nerve regeneration based on this in vitro dose–response analysis.
Do the fasciae of the soleus have a role in plantar fasciitis?
Authors: Ryskalin Larisa , Morucci Gabriele , Soldani Paola , Gesi Marco 
Published: August 2023

AbstractPlantar fasciitis is a chronic, self‐limiting, and painful disabling condition affecting the inferomedial aspect of the heel, usually extending toward the metatarsophalangeal joints. There is compelling evidence for a strong correlation between Achilles tendon (AT) loading and plantar aponeurosis (PA) tension. In line with this, tightness of the AT is found in almost 80% of patients affected by plantar fasciitis. A positive correlation has also been reported between gastrocnemius‐soleus tightness and heel pain severity in this condition. Despite its high prevalence, the exact etiology and pathological mechanisms underlying plantar heel pain remain unclear. Therefore, the aim of the present paper is to discuss the anatomical and biomechanical substrates of plantar fasciitis with special emphasis on the emerging, though largely neglected, fascial system. In particular, the relationship between the fascia, triceps surae muscle, AT, and PA will be analyzed. We then proceed to discuss how structural and biomechanical alterations of the muscle‐tendon‐fascia complex due to muscle overuse or injury can create the conditions for the onset of PA pathology. A deeper knowledge of the possible molecular mechanisms underpinning changes in the mechanical properties of the fascial system in response to altered loading and/or muscle contraction could help healthcare professionals and clinicians refine nonoperative treatment strategies and rehabilitation protocols for plantar fasciitis.
Comprehensive analysis of predictive factors for upstaging in intraprostatic cancer after radical prostatectomy: Different patterns of spread exist in lesions at different locations
Authors: Wu Shangrong , Jiang Yuchen , Liang Zhengxin , Chen Shuaiqi , Sun Guangyu , Ma Shenfei , Chen Kaifei , Liu Ranlu 
Published: August 2023

AbstractBackgroundAccurate assessment of the clinical staging is crucial for determining the need for radical prostatectomy (RP) in prostate cancer (PCa). However, the current methods for PCa staging may yield incorrect results. This study aimed to comprehensively analyze independent predictors of postoperative upstaging of intraprostatic cancer.MethodsWe conducted a retrospective analysis of data from intraprostatic cancer patients who underwent radical surgery between March 2019 and December 2022. Intraprostatic cancer was defined as a lesion confined to the prostate, excluding cases where multiparameter magnetic resonance imaging (mpMRI) showed the lesion in contact with the prostatic capsule. We assessed independent predictors of extraprostatic extension (EPE) and analyzed their association with positive surgical margin (PSM) status. In addition, based on the distance of the lesion from the capsule on mpMRI, we divided the patients into non‐transition zone and transition zone groups for further analysis.ResultsA total of 500 patients were included in our study. Logistic regression analysis revealed that biopsy Gleason grade group (GG) (odds ratio, OR: 1.370, 95% confidence interval, CI: 1.093–1.718) and perineural invasion (PNI) (OR: 2.746, 95% CI: 1.420–5.309) were predictive factors for postoperative EPE. Both biopsy GG and PNI were associated with lateral (GG: OR: 1.270, 95% CI: 1.074–1.501; PNI: OR: 2.733, 95% CI: 1.521–4.911) and basal (GG: OR: 1.491, 95% CI: 1.194–1.862; PNI: OR: 3.730, 95% CI: 1.929–7.214) PSM but not with apex PSM (GG: OR: 1.176, 95% CI: 0.989–1.399; PNI: OR: 1.204, 95% CI: 0.609–2.381) after RP. Finally, PNI was an independent predictor of EPE in the transition zone (OR: 11.235, 95% CI: 2.779–45.428) but not in the non‐transition zone (OR: 1.942, 95% CI: 0.920–4.098).ConclusionPNI and higher GG may indicate upstaging of tumors in patients with intraprostatic carcinoma. These two factors are associated with PSM in locations other than the apex of the prostate. Importantly, cancer in the transition zone of the prostate is more likely to spread externally through nerve invasion than cancer in the non‐transition zone.
Three New Labdane‐Type Diterpenoids from the Fruits of Amomum villosum and Their Anti‐Inflammatory Activities
Authors: Zhang Qing‐Qing , Liu Ke‐Xin , Li Yu‐Xia , Sun De‐Juan , Li Hua , Chen Li‐Xia 
Published: August 2023

AbstractThree new labdane‐type diterpenoids, calcaratarin E, villosumtriol, and 12‐epi‐villosumtriol (1–3) were isolated from the fruits of Amomum villosum, along with seven known diterpenoids (4–10). Through comprehensive analysis of chemical evidence and spectral data including UV, 1D and 2D NMR, HR‐ESI‐MS, IR, and X‐ray crystallography, the structures of these novel compounds were successfully determined. Additionally, the inhibitory effects of compounds 2–10 on NO production in lipopolysaccharide (LPS)‐induced RAW264.7 cells were evaluated. Notably, compound 6 exhibited the most significant inhibitory effect with an IC50 value of 1.74±0.69 μM.
Enantioselective Ni‐Catalyzed Three‐Component Dicarbofunctionalization of Alkenes
Authors: Dong Zhan , Song Liangliang , Chen Liang‐An 
Published: August 2023

AbstractAsymmetric multicomponent reactions are considered as efficient protocols for constructing complex chiral molecules because of their step‐ and atom‐economy. Nickel‐catalyzed asymmetric three‐component dicarbofunctionalization of alkenes has been well developed in recent years, which is used in the area of total synthesis of natural products and late‐stage modification of drugs because of the rapid incorporation of chiral sp3‐enriched carbon centers. In this concept, the significant breakthroughs of this field are summarized, together with the related mechanisms. Moreover, the remaining challenges and potential opportunities of multicomponent dicarbofunctionalization are also highlighted.