bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous features of ternary hybrid nanoparticles on thermal radiative flow configured by Darcy–Forchheimer porous surface
Authors: Nasir Saleem , Sirisubtawee Sekson , Akkurt Nevzat , Ali Ishtiaq , Gul Taza , Juntharee Pongpol 
Published: March 2023

Due to its remarkable thermodynamic development in various engineering sciences, the dispersion of nanostructures in classical base liquids is receiving greater attention from researchers and scientists. In light of the aforementioned inspirations, the suggested research is associated with using a water-based ternary-hybrid nanofluid that contains three unique nanostructures, silicon dioxide, titanium dioxide and aluminum oxide to optimize the heating process in science and engineering. In this situation, the influence of a chemically reactive magneto-hydrodynamics (MHD) Darcy–Forchheimer ternary hybrid composites transport involving nonlinear radiation across an exponentially permeable stretched surface is highlighted with the model’s physical initial and boundary constraints. The simulation of the heat expression also includes the impacts of nonlinear thermal radiations, energy supply, energy dissipation and magnetic force. Furthermore, the interpretation of Buongiorno’s theory involves spontaneous and thermophoresis diffusions. Entropy analysis is explained using the second law of thermodynamics. We converted the model framework for fluid movement, energy and mass transfer (together with ternary hybrid nanofluid characteristics) into self-similar nondimensional differential equations, that were then further analytically evaluated by using the homotopy asymptotic method (HAM) technique via Mathematica software. The acquired results are illustrated numerically and graphically to study the behavior of fluid flow, heat, concentration distribution, drag force, rate of heat and mass transfer for various emergent components to gain scientific comprehension. With the growing values of magnetic, porosity and Forchheimer number, the nature of the velocity profile goes down.
Visages of geodiversity and geoheritage: a multidisciplinary approach to valuing, conserving and managing abiotic nature
Authors: Kubalíková Lucie , Irapta Paula Naomi , Pál Márton , Zwoliński Zbigniew , Coratza Paola , van Wyk de Vries Benjamin 
Published: March 2023

Abstract
Geodiversity and geoheritage studies are multidisciplinary, drawing from all sides of geosciences and extending them into the humanities, geoarchaeology, spatial planning, territorial and risk management, economics, tourism, or culture using integrated and interdisciplinary research approaches. During the last three decades, geodiversity and geoheritage research experienced a considerable growth that confirms both scientific and public relevance of these topics. In this introductory text, a brief review of current literature is presented and the importance of geodiversity and geoheritage for sustainable development, geohazard resilience and associated themes is discussed. Last, but not least, the aims and structure of this volume are outlined.
Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors
Authors: McDermott Martina S.J. , O'Brien Neil A. , Hoffstrom Benjamin , Gong KeWei , Lu Ming , Zhang Jun , Luo Tong , Liang Min , Jia Weiping , Hong Jenny J. , Chau Kevin , Davenport Simon , Xie Bin , Press Michael F. , Panayiotou Richard , Handly-Santana Abram , Brugge Joan S. , Presta Leonard , Glaspy John , Slamon Dennis J. 
Published: March 2023

Abstract

Purpose:
Claudin-6 (CLDN6) is expressed at elevated levels in multiple human cancers including ovarian and endometrial malignancies, with little or no detectable expression in normal adult tissue. This expression profile makes CLDN6 an ideal target for development of a potential therapeutic antibody–drug conjugate (ADC). This study describes the generation and preclinical characterization of CLDN6–23-ADC, an ADC consisting of a humanized anti-CLDN6 monoclonal antibody coupled to monomethyl auristatin E (MMAE) via a cleavable linker.

Experimental Design:
A fully humanized anti-CLDN6 antibody was conjugated to MMAE resulting in the potential therapeutic ADC, CLDN6–23-ADC. The antitumor efficacy of CLDN6–23-ADC was assessed for antitumor efficacy in CLDN6-positive (CLDN6+) and -negative (CLDN6−) xenografts and patient-derived xenograft (PDX) models of human cancers.

Results:
CLDN6–23-ADC selectively binds to CLDN6, versus other CLDN family members, inhibits the proliferation of CLDN6+ cancer cells in vitro, and is rapidly internalized in CLDN6+ cells. Robust tumor regressions were observed in multiple CLDN6+ xenograft models and tumor inhibition led to markedly enhanced survival of CLDN6+ PDX tumors following treatment with CLDN6–23-ADC. IHC assessment of cancer tissue microarrays demonstrate elevated levels of CLDN6 in 29% of ovarian epithelial carcinomas. Approximately 45% of high-grade serous ovarian carcinomas and 11% of endometrial carcinomas are positive for the target.

Conclusions:
We report the development of a novel ADC, CLDN6–23-ADC, that selectively targets CLDN6, a potential onco-fetal-antigen which is highly expressed in ovarian and endometrial cancers. CLDN6–23-ADC exhibits robust tumor regressions in mouse models of human ovarian and endometrial cancers and is currently undergoing phase I study.
Precision Cut Lung Slices as a Preclinical Model for Non–Small Cell Lung Cancer Chemoprevention
Authors: Sompel Kayla , Smith Alex J. , Hauer Caroline , Elango Alamelu P. , Clamby Eric T. , Keith Robert L. , Tennis Meredith A. 
Published: March 2023

Abstract

Lung cancer chemoprevention is critical to addressing cancer burden in high-risk populations. Chemoprevention clinical trials rely on data from preclinical models; however, in vivo studies have high financial, technical, and staffing requirements. Precision cut lung slices (PCLS) provide an ex vivo model that maintains the structure and function of native tissues. This model can be used for mechanistic investigations and drug screenings and reduces the number of animals and time required to test hypotheses compared with in vivo studies. We tested the use of PCLS for chemoprevention studies, demonstrating recapitulation of in vivo models. Treatment of PCLS with the PPARγ agonizing chemoprevention agent iloprost produced similar effects on gene expression and downstream signaling as in vivo models. This occurred in both wild-type tissue and Frizzled 9 knockout tissue, a transmembrane receptor required for iloprost's preventive activity. We explored new areas of iloprost mechanisms by measuring immune and inflammation markers in PCLS tissue and media, and immune cell presence with immunofluorescence. To demonstrate the potential for drug screening, we treated PCLS with additional lung cancer chemoprevention agents and confirmed activity markers in culture. PCLS offers an intermediate step for chemoprevention research between in vitro and in vivo models that can facilitate drug screening prior to in vivo studies and support mechanistic studies with more relevant tissue environments and functions than in vitro models.

Prevention Relevance:
PCLS could be a new model for premalignancy and chemoprevention research, and this work evaluates the model with tissue from prevention-relevant genetic and carcinogen exposed in vivo mouse models, in addition to evaluating chemoprevention agents.
Effectiveness and Cost-Effectiveness of Team-Based Care for Hypertension: A Meta-Analysis and Simulation Study
Authors: Bryant Kelsey B. , Rao Aditi S. , Cohen Laura P. , Dandan Nadine , Kronish Ian M. , Barai Nikita , Fontil Valy , Zhang Yiyi , Moran Andrew E. , Bellows Brandon K. 
Published: March 2023

Background:
Team-based care (TBC), a team of ≥2 healthcare professionals working collaboratively toward a shared clinical goal, is a recommended strategy to manage blood pressure (BP). However, the most effective and cost-effective TBC strategy is unknown.

Methods:
A meta-analysis of clinical trials in US adults (aged ≥20 years) with uncontrolled hypertension (≥140/90 mm Hg) was performed to estimate the systolic BP reduction for TBC strategies versus usual care at 12 months. TBC strategies were stratified by the inclusion of a nonphysician team member who could titrate antihypertensive medications. The validated BP Control Model-Cardiovascular Disease Policy Model was used to project the expected BP reductions out to 10 years and simulate cardiovascular disease events, direct healthcare costs, quality-adjusted life years, and cost-effectiveness of TBC with physician and nonphysician titration.

Results:
Among 19 studies comprising 5993 participants, the 12-month systolic BP change versus usual care was −5.0 (95% CI, −7.9 to −2.2) mm Hg for TBC with physician titration and −10.5 (−16.2 to −4.8) mm Hg for TBC with nonphysician titration. Relative to usual care at 10 years, TBC with nonphysician titration was estimated to cost $95 (95% uncertainty interval, −$563 to $664) more per patient and gain 0.022 (0.003–0.042) quality-adjusted life years, costing $4400/quality-adjusted life year gained. TBC with physician titration was estimated to cost more and gain fewer quality-adjusted life years than TBC with nonphysician titration.

Conclusions:
TBC with nonphysician titration yields superior hypertension outcomes compared with other strategies and is a cost-effective way to reduce hypertension-related morbidity and mortality in the United States.
Building Community Consensus for Scientific Metadata with YAMZ
Authors: Greenberg Jane , McClellan Scott , Rauch Christopher , Zhao Xintong , Kelly Mat , An Yuan , Kunze John , Orenstein Rachel , Porter Claire , Meschke Vanessa , Toberer Eric 
Published: March 2023

ABSTRACTThis paper reports on a demonstration of YAMZ (Yet Another Metadata Zoo) as a mechanism for building community consensus around metadata terms. The demonstration is motivated by the complexity of the metadata standards environment and the need for more user-friendly approaches for researchers to achieve vocabulary consensus. The paper reviews a series of metadata standardization challenges, explores crowdsourcing factors that offer possible solutions, and introduces the YAMZ system. A YAMZ demonstration is presented with members of the Toberer materials science laboratory at the Colorado School of Mines, where there is a need to confirm and maintain a shared understanding for the vocabulary supporting research documentation, data management, and their larger metadata infrastructure. The demonstration involves three key steps: 1) Sampling terms for the demonstration, 2) Engaging graduate student researchers in the demonstration, and 3) Reflecting on the demonstration. The results of these steps, including examples of the dialog provenance among lab members and voting, show the ease with YAMZ can facilitate building metadata vocabulary consensus. The conclusion discusses implications and highlights next steps.
Maturation of the Bandung Project with Lessons from the Regional Comprehensive Economic Partnership (RCEP)
Authors: Campbell Horace G. 
Published: March 2023

Abstract
January 2022 marked the rollout of the largest trading block in the world, the RCEP. It is the argument of the paper that this trading block emerged out of four periods of the Bandung Process that was launched in 1955 for the process of decolonization. In 1954, the Vietnamese army defeated the army of France and Dien Bien Phu. A year later, Vietnam was one of the founding members of the Bandung process. This was the project initiated by the formerly colonized states to form a global coalition to resist imperialism. Organizing to consolidate independence under the banner of the struggles for bread, freedom and justice, the Bandung movement anchored the nonaligned movement, the struggles in Palestine, the struggles against apartheid and the struggles for a New International Economic Order (NIEO). As a member of the 10 member Association of South East Asian Nations (ASEAN), Vietnam has been at the forefront of opposing western economic and military domination of Asia. This resistance had matured in the formation of the Regional Comprehensive Economic Partnership agreement which was signed in November 2020. RCEP brings together China, Japan, South Korea, Australia, New Zealand and all 10 members of the Association of Southeast Asian Nations (ASEAN). The paper traces four moments of the Bandung Process and brought to the fore the importance of the current historical conjuncture when Vietnamese diplomatic leadership within ASEAN facilitated this new trade deal. The combination of the intensified warfare, global health pandemics, crisis of global warming, the fragility of capital, the weaponization of trade and finance and instability generated by the US political system, along with systemic racism continues to point to the necessity for a new international monetary and financial system (IMFS). From the Bandung era, through the financial crises of capitalism, the societies of the South have been seeking new institutions and formations to break the stranglehold of western imperialism and white supremacy. The paper will highlight the possibilities offered by RECP in the context of the continued struggles for a New International Economic Order in opposition to the US project of the weaponization of trade and finance.
Towards Use of Capability, Opportunity and Motivation Model in Predicting Ugandan Citizens’ Behavior towards Engagement in Policy Formulation through E-participation
Authors: Nabafu Robinah , Moya Musa B. , Isoh Alain V. N. , Kituyi Geoffrey M. , Ngwa Oneurine 
Published: March 2023

Abstract
Though the government of Uganda has put in place a fully-fledged ministry of ICT and allowed citizens to electronically participate in policy formulation following article 37 of the constitution of Uganda, most citizens are still reluctant. This reluctance has led to limited participation and formulation of unrepresentative policies, loss of citizens’ trust in government, and defiance of formulated policies. This study’s focus was to apply the capability, opportunity, and motivation (COM-B) model to understand how citizens’ engagement behaviors toward policy formulation could be improved. The following hypotheses were tested: There is a significant influence of motivation and opportunity on capability; Capability mediates the relationship between motivation, opportunity, and engagement; and there is a significant influence of capability, opportunity, and motivation on engagement. A survey was used to collect data from 361 respondents in four regions in Uganda using a multistage and simple random sampling method. Collected data were analysed using SPSS and SEM. Study findings found a significant influence of Motivation and Opportunity on Capability; a significant direct influence of Opportunity and Capability on engagement; and a significant indirect influence of motivation on engagement through capability. Implying that Capability partially mediates the relationship between Opportunity and engagement but fully mediates the relationship between Motivation and engagement. However, Opportunity had the strongest influence on capability and engagement behaviors. This study’s contribution was in testing the applicability of the COM-B model in policy formulation in Uganda. The recommendation to policymakers is to increase opportunity since it has a stronger influence on both Capability and engagement behaviors.
Deep Learning Forecast Uncertainty for Precipitation over the Western United States
Authors: Hu Weiming , Ghazvinian Mohammadvaghef , Chapman William E. , Sengupta Agniv , Ralph Fred Martin , Delle Monache Luca 
Published: March 2023

Abstract
Reliably quantifying uncertainty in precipitation forecasts remains a critical challenge. This work examines the application of a deep learning (DL) architecture, Unet, for postprocessing deterministic numerical weather predictions of precipitation to improve their skills and for deriving forecast uncertainty. Daily accumulated 0–4-day precipitation forecasts are generated from a 34-yr reforecast based on the West Weather Research and Forecasting (West-WRF) mesoscale model, developed by the Center for Western Weather and Water Extremes. The Unet learns the distributional parameters associated with a censored, shifted gamma distribution. In addition, the DL framework is tested against state-of-the-art benchmark methods, including an analog ensemble, nonhomogeneous regression, and mixed-type meta-Gaussian distribution. These methods are evaluated over four years of data and the western United States. The Unet outperforms the benchmark methods at all lead times as measured by continuous ranked probability and Brier skill scores. The Unet also produces a reliable estimation of forecast uncertainty, as measured by binned spread–skill relationship diagrams. Additionally, the Unet has the best performance for extreme events (i.e., the 95th and 99th percentiles of the distribution) and for these cases, its performance improves as more training data are available.

Significance Statement
Accurate precipitation forecasts are critical for social and economic sectors. They also play an important role in our daily activity planning. The objective of this research is to investigate how to use a deep learning architecture to postprocess high-resolution (4 km) precipitation forecasts and generate accurate and reliable forecasts with quantified uncertainty. The proposed approach performs well with extreme cases and its performance improves as more data are available in training.
Laparoscopic Paraesophageal Hernia Repair With Nissen Fundoplication in a Patient With Ancient Schwannoma of the Gastroesophageal Junction
Authors: Enciso Benjamin M. , Stadsvold Brianna , Bolduc Aaron R. , Hilton Renee L. 
Published: March 2023

Schwannomas are mostly benign tumors that originate from Schwann cells and are rarely seen in the gastrointestinal tract. Our patient is a 65-year-old female who was found to have a 1.5 cm lesion at the gastroesophageal junction, which was clipped and excised on endoscopy. Histologic examination demonstrated an ancient schwannoma. Two years afterward, she presented to our clinic for a large type III paraesophageal hernia. We took her to the operating room for a laparoscopic paraesophageal hernia repair and Nissen fundoplication. We performed an upper endoscopy during the case and found no recurrence of the ancient schwannoma. The case progressed well without complications. She was discharged on postoperative day 1 after tolerating a pureed diet and reported no issues in follow-up. In summary, we demonstrate a successful surgical outcome in a patient who had undergone resection of this rare tumor 2 years prior to her surgery.
Changing perspectives among pre-health undergraduates through a brief weight bias pedagogical intervention
Authors: Bolter Nicole D , Sosna Daria , Arauzo Megan , George Gretchen L 
Published: March 2023

Background: Weight stigma and bias are present in education, employment, and health care institutions, and have increased in recent years. College students in pre-health majors have been documented to hold weight biases, and interventions to mitigate these beliefs have had varying results. Objectives: This study’s purpose was to assess the impact of a pedagogical intervention regarding weight stigma outcomes among first-year students. Method: Three instructors of lower-division health and social science courses implemented a 3-module lecture series on weight stigma, the environmental sources of weight variability, and body appreciation. Participants ( N = 81; 48 from intervention (INT) classrooms, 33 from comparison [COM] classrooms) completed an end-of-semester survey regarding their anti-fat biases, fat phobia, and body appreciation, and a subset ( n = 13) participated in a semi-structured interview about their experiences. Results: Results revealed no outcome differences between the treatment versus comparison groups, although self-reported body mass index (BMI) was a significant covariate ( p = .008). A significant correlation emerged between BMI and fear of fat scores for COM ( r = .52, p < .01) but not for INT students ( r = .28, p > .05), suggesting the intervention may have impacted how students form their anti-fat biases in relation to their BMI. Qualitative findings yielded five themes – connected course material with personal experiences; learned about weight stigma; shifted perspective on weight stigma; recognised application of weight stigma; material to future career; and valued learning about weight stigma – that provided insight into how the intervention positively affected students. Conclusion: Informed by the findings from this study, future interventions should take a more immersive pedagogical approach.
A framework for the implementation of consultation-liaison psychiatry from the characteristics of psychosomatic consultations at a general hospital in China
Authors: Xue Zou , Yanwen Liu , Wenwen Zhang , Mei Li , Huihui Jing , Hongbin Lu , Ying Wang , Ning Liu , Le Han , Xueyang Han , Yitong Hou , Mingxiao Ma 
Published: March 2023

Objective To describe the characteristics of a consultation-liaison psychiatry (CLP) service at a general hospital in China, compare the literature on CLP in other hospitals in China and abroad, and identify reasons for the differences. Methods The medical records of all inpatients who received liaison consultations in the first year of the establishment of Xi’an International Medical Center Hospital were reviewed. Demographic data, specific department, number of consultations, reasons for consultation, outcome of consultation, and follow-up information on patients was collected. Results A total of 630 patients were enrolled during the first year of the hospital’s opening, of which 45.2% were male and 54.8% were female. A total of 89.2% of non-psychiatric departments requested a psychosomatic consultation. The percentage of middle-aged and elderly patients was 75.6%, of whom 61.6% were aged 45 to 74 years. The internal medicine department requested the highest number of consultations (48.2%), including those from respiratory medicine (12.1%), neurology (12.1%), gastroenterology (12.1%), and cardiology (12.1%). Among surgical patients, orthopedic patients (6.5%) comprised the majority of consults. The main reasons for requesting a psychosomatic consultation were depressive symptoms (139 cases, 22.8%), anxiety symptoms (137 cases, 22.5%), sleep problems (111 cases, 18.2%), and hallucinations, delusions, or behavioral problems (68 cases, 11.2%), accounting for a total of 74.6% of consultations (455/630). Conclusion A significant gap exists between the level of CLP services in China and developed regions in Europe and the United States, mainly due to low psychiatric consultation rates and poor quality CLP services.