bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of selenium supplementation for mild-to-moderate Graves’ ophthalmopathy in a selenium-sufficient area (SeGOSS trial): study protocol for a phase III, multicenter, open-label, randomized, controlled intervention trial
Authors: Chung Chae Won , Jung Kyong Yeun , Jung Eun Hye , Lee Min Joung , Park Young Joo , Lee Jeong Kyu , Ahn Hwa Young , Cho Sun Wook 
Published: April 2023

Abstract
Background
The therapeutic effect of selenium has been demonstrated in mild Graves’ ophthalmopathy (GO) in a European region where selenium status is suboptimal. However, there is a lack of evidence to support selenium use in selenium-sufficient areas. The aim of this study is to evaluate the therapeutic effect of selenium in mild-to-moderate GO in selenium-sufficient South Korea.

Methods
The SeGOSS trial is a multicenter, prospective, randomized, open-label trial in South Korea. Eighty-four patients aged 19 years or older with mild-to-moderate GO will be randomized to receive either vitamin B complex alone or vitamin B complex with selenium for 6 months with three monthly follow-up visits. The primary outcome is comparison of the improvement in quality of life at 6 months from baseline between the control and selenium groups. The secondary outcomes are intergroup differences in changes in quality of life at 3 months, clinical activity of GO at 3 and 6 months, thyroid autoantibody titers at 3 and 6 months, and the response rate at 3 and 6 months from baseline. Quality of life will be measured by questionnaire for patients with GO, and the clinical activity of GO will be evaluated by the clinical activity score (CAS). A positive response is defined as either changes in the CAS < 0 or the changes in the GO-QOL score ≥ 6.

Discussion
The SeGOSS study will evaluate the therapeutic potential of selenium for mild-to-moderate GO in a selenium-sufficient area and provide support in tailoring better treatment for GO.

Trial registration
KCT0004040. Retrospectively registered on 5 June 2019. https://cris.nih.go.kr/cris/search/detailSearch.do/14160.
Indoor resting behavior of Aedes aegypti (Diptera: Culicidae) in northeastern Thailand
Authors: Seang-arwut Chadapond , Hanboonsong Yupa , Muenworn Vithee , Rocklöv Joacim , Haque Ubydul , Ekalaksananan Tipaya , Paul Richard E. , Overgaard Hans J. 
Published: April 2023

Abstract
Background
Aedes aegypti is a vector of several arboviruses, notably dengue virus (DENV), which causes dengue fever and is often found resting indoors. Culex spp. are largely nuisance mosquitoes but can include species that are vectors of zoonotic pathogens. Vector control is currently the main method to control dengue outbreaks. Indoor residual spraying can be part of an effective vector control strategy but requires an understanding of the resting behavior. Here we focus on the indoor-resting behavior of Ae. aegypti and Culex spp. in northeastern Thailand.

Methods
Mosquitoes were collected in 240 houses in rural and urban settings from May to August 2019 at two collection times (morning/afternoon), in four room types (bedroom, bathroom, living room and kitchen) in each house and at three wall heights (< 0.75 m, 0.75–1.5 m, > 1.5 m) using a battery-driven aspirator and sticky traps. Household characteristics were ascertained. Mosquitoes were identified as Ae. aegypti, Aedes albopictus and Culex spp. Dengue virus was detected in Ae. aegypti. Association analyses between urban/rural and within-house location (wall height, room), household variables, geckos and mosquito abundance were performed.

Results
A total of 2874 mosquitoes were collected using aspirators and 1830 using sticky traps. Aedes aegypti and Culex spp. accounted for 44.78% and 53.17% of the specimens, respectively. Only 2.05% were Ae. albopictus. Aedes aegypti and Culex spp. rested most abundantly at intermediate and low heights in bedrooms or bathrooms (96.6% and 85.2% for each taxon of the total, respectively). Clothes hanging at intermediate heights were associated with higher mean numbers of Ae. aegypti in rural settings (0.81 [SEM: 0.08] vs. low: 0.61 [0.08] and high: 0.32 [0.09]). Use of larval control was associated with lower numbers of Ae. aegypti (yes: 0.61 [0.08]; no: 0.70 [0.07]). All DENV-positive Ae. aegypti (1.7%, 5 of 422) were collected in the rural areas and included specimens with single, double and even triple serotype infections.

Conclusions
Knowledge of the indoor resting behavior of adult mosquitoes and associated environmental factors can guide the choice of the most appropriate and effective vector control method. Our work suggests that vector control using targeted indoor residual spraying and/or potentially spatial repellents focusing on walls at heights lower than 1.5 m in bedrooms and bathrooms could be part of an integrated effective strategy for dengue vector control.

Graphical Abstract
Molecular characteristics of breast tumors in patients screened for germline predisposition from a population-based observational study
Authors: Nacer Deborah F. , Vallon-Christersson Johan , Nordborg Nicklas , Ehrencrona Hans , Kvist Anders , Borg Åke , Staaf Johan 
Published: April 2023

Abstract
Background
Pathogenic germline variants (PGVs) in certain genes are linked to higher lifetime risk of developing breast cancer and can influence preventive surgery decisions and therapy choices. Public health programs offer genetic screening based on criteria designed to assess personal risk and identify individuals more likely to carry PGVs, dividing patients into screened and non-screened groups. How tumor biology and clinicopathological characteristics differ between these groups is understudied and could guide refinement of screening criteria.

Methods
Six thousand six hundred sixty breast cancer patients diagnosed in South Sweden during 2010–2018 were included with available clinicopathological and RNA sequencing data, 900 (13.5%) of which had genes screened for PGVs through routine clinical screening programs. We compared characteristics of screened patients and tumors to non-screened patients, as well as between screened patients with (n = 124) and without (n = 776) PGVs.

Results
Broadly, breast tumors in screened patients showed features of a more aggressive disease. However, few differences related to tumor biology or patient outcome remained significant after stratification by clinical subgroups or PAM50 subtypes. Triple-negative breast cancer (TNBC), the subgroup most enriched for PGVs, showed the most differences between screening subpopulations (e.g., higher tumor proliferation in screened cases). Significant differences in PGV prevalence were found between clinical subgroups/molecular subtypes, e.g., TNBC cases were enriched for BRCA1 PGVs. In general, clinicopathological differences between screened and non-screened patients mimicked those between patients with and without PGVs, e.g., younger age at diagnosis for positive cases. However, differences in tumor biology/microenvironment such as immune cell composition were additionally seen within PGV carriers/non-carriers in ER + /HER2 − cases, but not between screening subpopulations in this subgroup.

Conclusions
Characterization of molecular tumor features in patients clinically screened and not screened for PGVs represents a relevant read-out of guideline criteria. The general lack of molecular differences between screened/non-screened patients after stratification by relevant breast cancer subsets questions the ability to improve the identification of screening candidates based on currently used patient and tumor characteristics, pointing us towards universal screening. Nevertheless, while that is not attained, molecular differences identified between PGV carriers/non-carriers suggest the possibility of further refining patient selection within certain patient subsets using RNA-seq through, e.g., gene signatures.

Trial registration
The Sweden Cancerome Analysis Network – Breast (SCAN-B) was prospectively registered at ClinicalTrials.gov under the identifier NCT02306096.
Factor VII deficiency: a rare genetic bleeding disorder in a 7-year-old child: a case report
Authors: Salum Hajaj Mohamed , Lukumay Joyce , Muze Kandi , Swai Peter , Kindole Christina , Kipasika Honesta , Apollo Monica , Chirande Lulu , Furia Francis 
Published: April 2023

Abstract
Background
Factor VII deficiency is a rare inherited bleeding disorder that has similar clinical presentation to hemophilia.

Case report
A 7-year-old male child of African origin experienced recurrent nasal bleeding since 3 years of age and recurrent swelling of the joints that was remarkable at the age of 5–6 years. He received multiple blood transfusions and has been managed as a patient with hemophilia until he presented to our facility. Reviewed evaluation of the patient revealed abnormal prothrombin and normal activated partial thromboplastin time, FVII analysis showed activity level of less than 1%, and the diagnosis of FVII deficiency was made. The patient was treated with fresh frozen plasma, vitamin K injection, and tranexamic tablets.

Conclusion
Even though factor VII deficiency is an extremely rare bleeding disorder, it does occur in our setting. This case highlights the need for clinicians to consider this condition when faced with challenging patients presenting with bleeding disorders.
Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea
Authors: Liang Haoyu , Song Zhi-Man , Zhong Zheng , Zhang Dengwei , Yang Wei , Zhou Le , Older Ethan A. , Li Jie , Wang Huan , Zeng Zhirui , Li Yong-Xin 
Published: April 2023

Abstract
Background
Microbes produce diverse secondary metabolites (SMs) such as signaling molecules and antimicrobials that mediate microbe-microbe interaction. Archaea, the third domain of life, are a large and diverse group of microbes that not only exist in extreme environments but are abundantly distributed throughout nature. However, our understanding of archaeal SMs lags far behind our knowledge of those in bacteria and eukarya.

Results
Guided by genomic and metabolic analysis of archaeal SMs, we discovered two new lanthipeptides with distinct ring topologies from a halophilic archaeon of class Haloarchaea. Of these two lanthipeptides, archalan α exhibited anti-archaeal activities against halophilic archaea, potentially mediating the archaeal antagonistic interactions in the halophilic niche. To our best knowledge, archalan α represents the first lantibiotic and the first anti-archaeal SM from the archaea domain.

Conclusions
Our study investigates the biosynthetic potential of lanthipeptides in archaea, linking lanthipeptides to antagonistic interaction via genomic and metabolic analyses and bioassay. The discovery of these archaeal lanthipeptides is expected to stimulate the experimental study of poorly characterized archaeal chemical biology and highlight the potential of archaea as a new source of bioactive SMs.
The association between drug use and mortality in a norwegian prison cohort: a prospective cohort study
Authors: Tverborgvik Torill , Stavseth Marianne Riksheim , Bukten Anne 
Published: April 2023

Abstract
Background
Elevated mortality rates are found among people who have experienced incarceration, even long after release from prison. The mechanisms related to this excess mortality are complex products of both individual and situational factors. The aim of this study was to describe all-cause and cause-specific mortality among people with a history of imprisonment, and to examine both individual and situational factors associated with mortality.

Methods
In this prospective cohort study we used baseline survey data from the Norwegian Offender Mental Health and Addiction (NorMA) study (N = 733) linked with data from the Norwegian Cause of Death Registry during eight years of follow-up (2013–2021).

Results
At end of follow-up, 56 persons (8%) of the cohort were deceased; 55% (n = 31) due to external causes such as overdoses or suicides, and 29% (n = 16) to internal causes such as cancer or lung disease. Having a score > 24 on the Drug Use Disorders Identification Test (DUDIT), indicating likely drug dependence was highly associated with external causes of death (OR 3.31, 95% CI 1.34–8.16), while having a job before baseline imprisonment had a protective effect on all-cause mortality (OR 0.51, ,95% CI 0.28–0.95).

Conclusions
High DUDIT score at baseline were highly associated with external causes of death, even years after the DUDIT screening was done. Screening incarcerated people using validated clinical tools, such as the DUDIT, together with initiation of appropriate treatment, may contribute to reduced mortality in this marginalized population.
A survey on deep learning tools dealing with data scarcity: definitions, challenges, solutions, tips, and applications
Authors: Alzubaidi Laith , Bai Jinshuai , Al-Sabaawi Aiman , Santamaría Jose , Albahri A. S. , Al-dabbagh Bashar Sami Nayyef , Fadhel Mohammed A. , Manoufali Mohamed , Zhang Jinglan , Al-Timemy Ali H. , Duan Ye , Abdullah Amjed , Farhan Laith , Lu Yi , Gupta Ashish , Albu Felix , Abbosh Amin , Gu Yuantong 
Published: April 2023

AbstractData scarcity is a major challenge when training deep learning (DL) models. DL demands a large amount of data to achieve exceptional performance. Unfortunately, many applications have small or inadequate data to train DL frameworks. Usually, manual labeling is needed to provide labeled data, which typically involves human annotators with a vast background of knowledge. This annotation process is costly, time-consuming, and error-prone. Usually, every DL framework is fed by a significant amount of labeled data to automatically learn representations. Ultimately, a larger amount of data would generate a better DL model and its performance is also application dependent. This issue is the main barrier for many applications dismissing the use of DL. Having sufficient data is the first step toward any successful and trustworthy DL application. This paper presents a holistic survey on state-of-the-art techniques to deal with training DL models to overcome three challenges including small, imbalanced datasets, and lack of generalization. This survey starts by listing the learning techniques. Next, the types of DL architectures are introduced. After that, state-of-the-art solutions to address the issue of lack of training data are listed, such as Transfer Learning (TL), Self-Supervised Learning (SSL), Generative Adversarial Networks (GANs), Model Architecture (MA), Physics-Informed Neural Network (PINN), and Deep Synthetic Minority Oversampling Technique (DeepSMOTE). Then, these solutions were followed by some related tips about data acquisition needed prior to training purposes, as well as recommendations for ensuring the trustworthiness of the training dataset. The survey ends with a list of applications that suffer from data scarcity, several alternatives are proposed in order to generate more data in each application including Electromagnetic Imaging (EMI), Civil Structural Health Monitoring, Medical imaging, Meteorology, Wireless Communications, Fluid Mechanics, Microelectromechanical system, and Cybersecurity. To the best of the authors’ knowledge, this is the first review that offers a comprehensive overview on strategies to tackle data scarcity in DL.
In-TFK: a scalable traditional food knowledge platform, a new traditional food dataset, platform, and multiprocess inference service
Authors: Mursanto Petrus , Wibisono Ari , Fahira Puteri Khatya , Rahmadhani Zulia Putri , Wisesa Hanif Arief 
Published: April 2023

AbstractTraditional Food Knowledge (TFK) is needed to define the acculturation of culture, society, and health in the context of food. TFK is essential for a human’s cultural, economic, and health aspects. Variations of ethnicity, culture, and lifestyle affect the diversity of traditional Indonesian food. Recognition of food is needed to maintain the sustainability of traditional food. Nowadays, there are many food dataset collections, but there needs to be a dataset that specifically collects standard food datasets. Our main contributions to the TFK research field are professional food image data acquisition, innovative development of an automatic, scalable food recognition system, and multi-process inference service. There are 34 variations of traditional foods from all regions in Indonesia that were acquired in this dataset. The dataset comprises 1644 high-quality images captured by professional cameras and 1020 by a smartphone. Several deep learning models are implemented in food recognition systems. This system can accommodate the addition and reduction of food variations in the knowledge recognition system and is capable of multiple concurrent requests at a time. The current prototype incorporates traditional types of food from Indonesia. However, the food model can also be expanded to other countries traditional foods. The automatic recognition systems are evaluated using several deep-learning network models. The experiment results have shown that the AUROC score is 0.99, and the request success rate can be improved by 70% with a multiprocess inference service.
Neuromuscular activity of the lower‐extremities during running, landing and changing‐of‐direction movements in individuals with anterior cruciate ligament reconstruction: a review of electromyographic studies
Authors: Georgoulis Jim D. , Melissaridou Dimitra , Patras Kostas , Megaloikonomos Panayiotis D. , Trikoupis Ioannis , Savvidou Olga D. , Papagelopoulos Panayiotis J. 
Published: April 2023

AbstractPurposeRunning, jumping/landing and cutting/change of direction (CoD) are critical components of return to sport (RTS) following anterior cruciate ligament reconstruction (ACLR), however the electromyographic (EMG) activity patterns of the operated leg during the execution of these tasks are not clear.MethodsA systematic review was conducted to retrieve EMG studies during running, jumping/landing and cutting/(CoD) in ACLR patients. MEDLINE, PubMed, SPORTDiscus and Web of Science databases were searched from 2000 to May, 2022 using a combination of keywords and their variations: “anterior cruciate ligament reconstruction” OR “ACLR”, “electromyography” OR “EMG”, “running”, “jumping” OR “landing”, “cutting” OR “change‐of‐direction” OR “CoD”. The search identified studies comparing EMG data during running, landing and cutting/(CoD) between the involved limb and contralateral or control limbs. Risk of bias was assessed and quantitative analyses using effect sizes were performed.ResultsThirty two studies met the inclusion criteria. Seventy five percent (24/32) of the studies reported altered EMG activity pattern of the ACLR leg during running, jumping/landing and cutting/(CoD) when compared with either the healthy control leg or the contra‐lateral leg. Twelve studies showed decreased, delayed or earlier onset and delayed peak in quadriceps EMG activity with small to large effect sizes and 9 studies showed increased, delayed or earlier onset and delayed peak in hamstrings EMG activity with small to large effect sizes. Four studies showed a “hamstrings‐dominant” strategy i.e. decreased quadriceps coupled with increased hamstrings EMG activity in both running and jumping/landing irrespective of graft type. One study reported that on the grounds of decreased quadriceps activity, lower hamstrings EMG activity was predictive of ipsilateral re‐injury in ACLR patients.ConclusionThis systematic review of Level III evidence showed that the ACLR leg displays decreased quadriceps or increased hamstrings EMG activity or both despite RTS. Simultaneous decreased quadriceps and increased hamstrings EMG activity was shown for both running and jumping/landing. From a clinical perspective this “hamstrings dominant” strategy can serve as a protective mechanism against graft re‐injury.Level of evidenceIII.
Guiding prosthetic femoral version using 3D-printed patient-specific instrumentation (PSI): a pilot study
Authors: Moralidou Maria , Henckel Johann , Di Laura Anna , Hart Alister 
Published: April 2023

Abstract
Background
Implantation of the femoral component with suboptimal version is associated with instability of the reconstructed hip joint. High variability of Prosthetic Femoral Version (PFV) has been reported in primary Total Hip Arthroplasty (THA). Three-dimensional (3D) Patient-Specific Instrumentation (PSI) has been recently developed and may assist in delivering a PFV within the intended range.
We performed a pilot study to better understand whether the intra-operative use of a novel PSI guide, designed to deliver a PFV of 20°, results in the target range of PFV in primary cemented THA.

Methods
We analysed post-operative Computed-Tomography (CT) data of two groups of patients who underwent primary cemented THA through posterior approach; 1. A group of 11 patients (11 hips) for which the surgeon used an intra-operative 3D-printed stem positioning guide (experimental) 2. A group of 24 patients (25 hips) for which the surgeon did not use the guide (control). The surgeon aimed for a PFV of 20°, and therefore the guide was designed to indicate the angle at which the stem was positioned intra-operatively. PFV angles were measured using the post-operative 3D-CT models of the proximal femurs and prosthetic components in both groups. Our primary objective was to compare the PFV in both groups. Our secondary objective was to evaluate the clinical outcome.

Results
Mean (± SD) values for the PFV was 21.3° (± 4.6°) and 24.6° (± 8.2°) for the experimental and control groups respectively. In the control group, 20% of the patients reported a PFV outside the intended range of 10° to 30° anteversion. In the experimental group, this percentage dropped to 0%. Satisfactory clinical outcome was recorded in both groups.

Conclusion
The intra-operative use of a PSI PFV guide helped the surgeon avoid suboptimal PFV in primary cemented THA. Further studies are needed to evaluate if the PSI guide directly contributes to a better clinical outcome.
Mental health in Germany in the first weeks of the Russo-Ukrainian war
Authors: Gottschick Cornelia , Diexer Sophie , Massag Janka , Klee Bianca , Broda Anja , Purschke Oliver , Binder Mascha , Sedding Daniel , Frese Thomas , Girndt Matthias , Hoell Jessica I. , Michl Patrick , Gekle Michael , Mikolajczyk Rafael 
Published: April 2023

Background
In the connected world, although societies are not directly involved in a military conflict, they are exposed to media reports of violence.

Aims
We assessed the effects of such exposures on mental health in Germany during the military conflict in Ukraine.

Method
We used the German population-based cohort for digital health research, DigiHero, launching a survey on the eighth day of the Russo-Ukrainian war. Of the 27 509 cohort participants from the general population, 19 444 (70.7%) responded within 17 days. We measured mental health and fear of the impact of war compared with other fears (natural disasters or health-related).

Results
In a subsample of 4441 participants assessed twice, anxiety in the population (measured by the Generalised Anxiety Disorder-7 screener) was higher in the first weeks of war than during the strongest COVID-19 restrictions. Anxiety was elevated across the whole age spectrum, and the mean was above the cut-off for mild anxiety. Over 95% of participants expressed various degrees of fear of the impact of war, whereas the percentage for other investigated fears was 0.47–0.82. A one-point difference in the fear of the impact of war was associated with a 2.5 point (95% CI 2.42–2.58) increase in anxiety (11.9% of the maximum anxiety score). For emotional distress, the increase was 0.67 points (0.66–0.68) (16.75% of the maximum score).

Conclusions
The population in Germany reacted to the Russo-Ukrainian war with substantial distress, exceeding reactions during the strongest restrictions in the COVID-19 pandemic. Fear of the impact of war was associated with worse mental health.