bluuebunny/crossref_metadata_2025_split huggingface dataset:
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure
Authors: Boyle Keith B , Ellison Cara J , Elliott Paul R , Schuschnig Martina , Grimes Krista , Dionne Marc S , Sasakawa Chihiro , Munro Sean , Martens Sascha , Randow Felix 
Published: July 2023

AbstractInvasive bacteria enter the cytosol of host cells through initial uptake into bacteria‐containing vacuoles (BCVs) and subsequent rupture of the BCV membrane, thereby exposing to the cytosol intraluminal, otherwise shielded danger signals such as glycans and sphingomyelin. The detection of glycans by galectin‐8 triggers anti‐bacterial autophagy, but how cells sense and respond to cytosolically exposed sphingomyelin remains unknown. Here, we identify TECPR1 (tectonin beta‐propeller repeat containing 1) as a receptor for cytosolically exposed sphingomyelin, which recruits ATG5 into an E3 ligase complex that mediates lipid conjugation of LC3 independently of ATG16L1. TECPR1 binds sphingomyelin through its N‐terminal DysF domain (N'DysF), a feature not shared by other mammalian DysF domains. Solving the crystal structure of N'DysF, we identified key residues required for the interaction, including a solvent‐exposed tryptophan (W154) essential for binding to sphingomyelin‐positive membranes and the conjugation of LC3 to lipids. Specificity of the ATG5/ATG12‐E3 ligase responsible for the conjugation of LC3 is therefore conferred by interchangeable receptor subunits, that is, the canonical ATG16L1 and the sphingomyelin‐specific TECPR1, in an arrangement reminiscent of certain multi‐subunit ubiquitin E3 ligases.
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5
Authors: Hodáková Zuzana , Grishkovskaya Irina , Brunner Hanna L , Bolhuis Derek L , Belačić Katarina , Schleiffer Alexander , Kotisch Harald , Brown Nicholas G , Haselbach David 
Published: July 2023

AbstractUBR5 is a nuclear E3 ligase that ubiquitinates a vast range of substrates for proteasomal degradation. This HECT domain‐containing ubiquitin ligase has recently been identified as an important regulator of oncogenes, e.g., MYC, but little is known about its structure or mechanisms of substrate engagement and ubiquitination. Here, we present the cryo‐EM structure of human UBR5, revealing an α‐solenoid scaffold with numerous protein–protein interacting motifs, assembled into an antiparallel dimer that adopts further oligomeric states. Using cryo‐EM processing tools, we observe the dynamic nature of the UBR5 catalytic domain, which we postulate is important for its enzymatic activity. We characterise the proteasomal nuclear import factor AKIRIN2 as an interacting protein and propose UBR5 as an efficient ubiquitin chain elongator. This preference for ubiquitinated substrates and several distinct domains for protein–protein interactions may explain how UBR5 is linked to several different signalling pathways and cancers. Together, our data expand on the limited knowledge of the structure and function of HECT E3 ligases.
A psicologia do vencimento, da superação da cegueira a partir da teoria histórico-cultural
Authors: Ferrari de Melo Douglas Christian , Cristofoleti Rita De Cassia , Rossetto Elisabeth 
Published: July 2023

Este artigo consiste em, a partir da teoria histórico-cultural, entender como um cego se comporta psicologicamente diante da sua cegueira. A metodologia partiu de um estudo bibliográfico das obras de Vigotski e seus colaboradores (1993, 1997, 1998, 2012), além de outros pesquisadores vigotskianos para compreender que não existe uma psicologia do cego, mas uma psicologia do vencimento, da superação da cegueira. Os resultados mostraram que o trabalho da escola e do professor consiste em pensar na cegueira como um conjunto de possibilidades, desenvolver e aprofundar os outros sentidos. Todo trabalho educativo que busca pela supercompensação estrutura-se no desafio para vencer, superar a cegueira.
Conversando sobre as questões de método para a construção da pesquisa em educação
Authors: Fortunatti Keifer , De Farias Isabel Maria Sabino 
Published: July 2023

O texto tem por objetivo apresentar a resenha do livro Questões de método na construção da pesquisa em Educação, de autoria de Evandro Ghedin e Maria Amélia Santoro Franco (2011). A obra faz parte da Coleção Docência em Formação e foi publicado pela Editora Cortez em sua segunda edição, no ano de 2011. Dividido em seis capítulos, o presente livro é voltado para pesquisadores iniciantes e experientes na área da educação e busca utilizar o método como ponto de partida para discutir as raízes ontológicas, epistêmicas e metodológicas dos diferentes paradigmas de pesquisa. Pautado na premissa de que a pesquisa em educação se traduz na tripla relação entre texto, contexto e as pessoas, os autores estabelecem a relação entre metodologia e política, propondo que a pesquisa em educação deva proporcionar uma reflexão que colabore para ação tranformadora da própria prática educativa, possibilitando as mudanças e a emancipação dos sujeitos.
Currículo e cultura na educação de jovens e adultos: o estado do conhecimento das produções nos Programas de Pós-Graduação do Brasil
Authors: Soares Gênesis Guimarães , Cunha Júnior Adenilson Souza 
Published: July 2023

O objetivo deste artigo é apresentar o que tem sido pesquisado sobre currículo e cultura na Educação de Jovens e Adultos (EJA) por meio de um mapeamento das produções sobre currículo e cultura na EJA a partir de Dissertações e Teses desenvolvidas nos programas de Pós-Graduação do Brasil. Para a operacionalização do estudo, realizamos o levantamento de toda produção disponível no Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) do Instituto Brasileiro de Informação em Ciência e Tecnologia (IBICT), sem a utilização de demarcação temporal. Se tratando da visão epistemológica empregada, fizemos uso da compreensão da pesquisa bibliográfica do tipo estado do conhecimento enquanto perspectiva metodológica. Por seguinte, após o levantamento e análise dos resultados, obtivemos o quantitativo de 16 produções, entre teses e dissertações, que foram analisadas na integra e, posteriormente, categorizadas de modo quantitativo e qualitativo. Por fim, constatamos que as temáticas “políticas curriculares” e “currículo e formação” foram as mais recorrentes entre os estudos escolhidos. Considerando as categorias elencadas, apresentamos uma análise qualitativa de modo a integrar os resultados das produções. Assim sendo, podemos observar que os resultados indicam que as produções em currículo, cultura e EJA possuem diversas intersecções com objetos de pesquisa distintos, mas, sempre apresentam aspectos que são semelhantes, como é o caso da luta por um currículo próprio para a EJA e a formação de sujeitos críticos e reflexivos acerca da realidade concreta que os cinge.
A disputa pelo poder da escola: o projeto de educação domiciliar e sua nova modalidade de privatização
Authors: Ramos Géssica Priscila 
Published: July 2023

Este artigo tem como objeto o tema da educação domiciliar, tendo o Projeto de Lei n. 3.179, de 2012 (PL 3.179/12) - aprovado no dia 19 de maio de 2022, na Câmara dos Deputados e, atualmente, em tramitação no Senado Federal como Projeto de Lei n. 1.338/2022 (PL 1.338/22) - como marco dessa discussão. A partir de análise bibliográfica e documental, busca discutir o Projeto em sua estratégia de privatização da educação. Para tanto, discorre inicialmente sobre a diferenciação entre educação e educação escolar, apresentando, nesse contexto, o surgimento da escola e sua configuração na sociedade moderna, apresentando os elementos que a constitui e o poder que os circunda. Na sequência debate a inconstitucionalidade do PL em tramitação e como ele pretende sequestrar da escola aspectos que lhe são inerentes. Constata que o mesmo se situa no bojo de luta pelo poder da escola, que se revela agora a partir da estruturação de novos mecanismos de privatização que transcendem o campo da parceria público-privada na condução da educação nacional, mas passam pela tentativa do controle privado/doméstico dos elementos fundantes da escola desde à modernidade: o saber escolar, o trabalho educativo e a formação educacional escolar do sujeito.
Islamic and Conventional Banking: A Comparison of Financial Performance During the Covid-19 Pandemic
Authors: Safarda Resfauzi Norma , Wahyudi Rofiul , Mubarok Ferry Khusnul 
Published: July 2023

The research aims to compare the financial performance of Islamic banks with conventional banks during the covid-19 pandemic. The sampling method was a purposive sampling technique and obtained 3 Islamic banks and 3 conventional banks. The data analysis technique is descriptive statistical analysis and to answer the proposed hypothesis using the technique of independent sample t-test and Mann Whitney. Meanwhile, the CAR, NPF/NPL, and FDR/LDR ratios have no difference. Analysis showed that Islamic banks performed better in Capital Adequacy Ratio and Financing to Deposit Ratio. Conventional banks had a better performance from Return on Asset, Return on Equity, Non-Performing Loan, Operating Costs, and Operating Income.
Eden's Trauma and Her Ways to Overcome Her Trauma in Amber Smith's The Way I Used To Be
Authors: Putri Ira Atika 
Published: July 2023

The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5), defines trauma as an event that causes injury when a person is hit by death, sexual abuse, and others. Recovery from a traumatic event is usually a painful and lengthy process. Everyone has their reaction to dealing with the trauma they have experienced. This study aims to find out what events caused Eden's trauma and the way Eden overcame her trauma in the novel The Way I Used to Be by Amber Smith. This research belongs to the category of literary criticism that uses Sigmund Freud's psychoanalysis as its research approach. This study uses the trauma theory by Sigmund Freud. The source of the data in this research is the novel by Amber Smith, entitled The Way I Used To Be. This study reveals that the cause of the trauma experienced by Eden was sexual abuse by Kevin. Apart from that, other components support the increasing sense of trauma experienced by Eden. In this research, Eden's ways were also found to overcome the trauma she experienced. To overcome her trauma, Eden did several ways. Based on this research, the novel entitled The Way I Used To Be by Amber Smith can be used to illustrate how to deal with trauma well. For this reason, readers can use this novel as research material with topics other than trauma issues, such as how the personality changes of Eden's character after sexual abuse occurred.
Keywords: Trauma, Psychoanalysis, The Way I Used To Be
METODE IMAM AN NAWAWI DALAM PENYUSUNAN KITAB RIYADHUSSHOLIHIN
Authors: Jami Deni Zam 
Published: July 2023

Tujuan penelitian ini adalah untuk mengeksplorasi metode imam an Nawawi dalam proses penyusunan kitab Riyadhussolihin. Mengingat kitab Riyadhussolihin merupakan kitab hadits yang praktis dan pedoman pembinaan karakter muslim yang baik. Tidak heran kitab ini banyak dipelajari oleh orang-orang Muslim, baik dipelajari di Pondok Pesantren, Surau, Dayah, disampaikan dalam pengajian dan Majelis ta’lim serta menjadi rujukan dalam penelitian. Metode yang digunakan dalam penelitian ini adalah kualitatif yang bertumpu pada deskriftif analitik. Pendekatan yang digunakan adalah library research atau studi kepustakaan, yakni aktfitas membaca, menelaah, mengumpulkan, mengolah dan menganalisis data dengan bersandar pada bahan bacaan. Objek penelitian adalah kitab Riyadhussolihi sebagai sumber data utama serta buku-buku dan kitab-kitab yang berkaitan dengan kitab Riyadhussolihin sebagai sumber data sekunder. Hasil penelitian menunjukkan bahwa kitab Riyadhussolihin mengandung pembinaan akhlak baik hubungan dengan Allah, manusia, sesama makhluk dan pembinaan karakter. Hadits yang terdapat dalam kitab ini adalah 1896 buah hadits yang tersebar pada 19 kitab dan dalam setiap kitab ada 294 bab yang berisi hadist-hadits yang setema. Sumber penukilan an Nawawi dalam kitab Riyadhussolihin adalah hadits-hadits yang diriwayatkan oleh imam Bukhari, imam Muslim, imam Abu Daud, at Tirmidzi dan Ibnu Majaht . Dalam setiap kitab an Nawawi mengutip ayat-ayat al –Qur’an yang memiliki tema yang sama dengan judul bab. Dalam beberapa hadits yang dirasakan sulit dipahaminya, an Nawawi menjelaskan makna-makna kata-kata dalam redaksi hadits yang asing. Dalam bab taubah, an Nawawi mengutip pendapat para ulama untuk memperjelas bab yang dimaksud.
Kata kunci; metode, an Nawawi, Riyadhussolihin.
PEMBEBANAN NAFKAH IDDAH DAN MUT’AH DALAM PERKARA CERAI GUGAT DALAM TINJAUAN HUKUM ISLAM DI INDONESIA DAN MALAYSIA
Authors: Pratama Rizki Putra , Azkia Zuraidah , Bt Ismail A'dawiyah 
Published: July 2023

Gugatan perceraian yang dilakukan oleh istri seringkali tidak disertai dengan tuntutan tambahan kepada suami untuk memberikan Nafkah Iddah dan Mut’ah. Sebab banyak perkara yang terjadi dalam gugatan perceraian seorang istri tidak mendapatkan hak nafkah iddah dan mut’ah. Padahal pengajuan hak nafkah ini dapat di ajukan pada saat pengajuan gugatan cerai seperti dalam Putusan Pengadilan Agama Pangkalan Balai No.727/Pdt.G/2021/Pa.Pkb. Tujuan dari penulisan ini untuk mengetahui landasan hukum yang menjadi pertimbangan hakim mengenai pembebanan nafkah iddah dan mut’ah dalam perkara cerai gugat dan untuk memahami tinjauan hukum Islam di Indonesia dan Malaysia terhadap pembebanan nafkah iddah dan mut’ah dalam perkara cerai gugat. Penelitian ini menggunakan jenis penelitian lapangan atau yang disebut dengan (field research). Dari hasil penelitian ditemukan bahwa hakim memberikan putusan berdasarkan pertimbangan pembuktian pihak yang dihadirkan di persidangan, dimana ditemukan bukti bahwa penggugat tidak nusyuz sehingga berdasarkan teori keadilan dan perlindungan hak-hak perempuan, hakim dapat memberikan keputusan sesuai dengan ijtihad yang dilakukan. Selain itu, menurut hukum Islam di Indonesia sejalan dengan pasal 41 UU No.1 Tahun 1974. Sedangkan menurut hukum Islam di Malaysia sejalan dengan UU Keluarga Islam Enakmen Nomor 17 Tahun 2003.
Kata Kunci.: Cerai Gugat; Nafkah Iddah; Mut’ah
Unfolding the Landscape of Conflict
Authors: Suryanti Made Selly Dwi , Muttaqin M. Zaenul , Makmun Sukron 
Published: July 2023

This study aims to examine the role of the United Nations Fund for Women (UNIFEM) in upholding women's rights by helping victims of sexual violence in the Darfur region of Sudan. By extension, it explores whether the organisation provided an effective example of a feminist groups in the face of this issue. This research is descriptive, using qualitative methods. The data taken is based on relevant books, academic journals, and online material. The analytical tools used are the concepts of feminism and international cooperation. The results of this research show that, when attempting to solve the problem of sexual violence in Darfur, UNIFEM came to the aid of victims, collaborating with local institutions in the area. This resulted in positive outcomes for sexual violence victims in Darfur, though UNIFEM continues to face several challenges.

Keywords: Feminism, Sexual Violence, Conflict, UNIFEM
A Socio-Historical Study of Women's Rights Advocacy in Islamic Legal Construction
Authors: Ma'mun Sukron , Maliki Ibnu Akbar 
Published: July 2023

This article presents evidence that the construction of Islamic law is influenced by women's voices, experiences, and problems. It also offers a critique of the misogynistic narrative of Islamic law. Adopting a socio-historical approach with a women's perspective, this research demonstrates the inadequacy of current studies that argue that Islamic law places women in an inferior and subordinate position to men. Critical analysis of the asbabun nuzul text of the Qur'an is the primary analytical tool used in this study. Polygamy, khulu', zhihar, and inheritance are the four main issues examined, and the study shows that the complaints and advocacy of women played a critical role in shaping the Islamic law system. Women's perspectives serve as a spiritual foundation in the development of Islamic law and cannot be disregarded. By considering women's perspectives, fair benefits can be realised, and a sense of justice can be achieved for vulnerable groups, such as women.

Keywords: Women’s rights, women’s perspectives, Islamic legal construction, discrimination
An Improved Cheetah Optimizer for Accurate and Reliable Estimation of Unknown Parameters in Photovoltaic Cell/Module Models
Authors: Memon Zulfiqar Ali , Akbari Mohammad Amin , Zare Mohsen 
Published: July 2023

Solar photovoltaic systems are becoming increasingly popular due to their outstanding environmental, economic, and technical characteristics. To simulate, manage, and control photovoltaic (PV) systems, the primary challenge is identifying unknown parameters accurately and reliably as early as possible using a robust optimization algorithm. This paper proposes a newly developed cheetah optimizer (CO) and improved CO (ICO) to extract parameters from various PV models. This algorithm, inspired by cheetah hunting behavior, includes several basic strategies: searching, sitting, waiting, and attacking. Although this algorithm has shown remarkable capabilities in solving large-scale problems, it needs improvement concerning its convergence speed and computing time. Here, an improved CO (ICO) is presented to identify solar power model parameters for this purpose. Single-, double-, and PV module models are investigated to test ICO&#039;s parameter estimation performance. Statistical analysis uses minimum, mean, maximum, and standard deviation. Furthermore, to improve confidence in test results, Wilcoxon and Freidman rank nonparametric tests are also performed. Compared to other state-of-the-art optimization algorithms, the ICO algorithm is proven to be highly reliable and accurate when identifying PV parameters.
Validation of the Stopping Opioids After Surgery (SOS) Score for the Sustained Use of Prescription Opioids Following Orthopaedic Surgery
Authors: Crawford Alexander M. , Striano Brendan M. , Gong Jonathan , Koehlmoos Tracey P. , Simpson Andrew K. , Schoenfeld Andrew J. 
Published: July 2023

Background:
The Stopping Opioids after Surgery (SOS) score was developed to identify patients at risk for sustained opioid use following surgery. The SOS score has not been specifically validated for patients in a general orthopaedic context. Our primary objective was to validate the SOS score within this context.

Methods:
In this retrospective cohort study, we considered a broad array of representative orthopaedic procedures performed between January 1, 2018, and March 31, 2022. These procedures included rotator cuff repair, lumbar discectomy, lumbar fusion, total knee and total hip arthroplasty, open reduction and internal fixation (ORIF) of ankle fracture, ORIF of distal radial fracture, and anterior cruciate ligament reconstruction. The performance of the SOS score was evaluated by calculating the c-statistic, receiver operating characteristic curve, and the observed rates of sustained prescription opioid use (defined as uninterrupted prescriptions of opioids for ≥90 days) following surgery. For our sensitivity analysis, we compared these metrics among various time epochs related to the COVID-19 pandemic.

Results:
A total of 26,114 patients were included, of whom 51.6% were female and 78.1% were White. The median age was 63 years. The observed prevalence of sustained opioid use was 1.3% (95% confidence interval [CI], 1.2% to 1.5%) in the low-risk group (SOS score of <30), 7.4% (95% CI, 6.9% to 8.0%) in the medium-risk group (SOS score of 30 to 60), and 20.8% (95% CI, 17.7% to 24.2%) in the high-risk group (SOS score of >60). The performance of the SOS score in the overall group was strong, with a c-statistic of 0.82. The performance of the SOS score showed no evidence of worsening over time. The c-statistic was 0.79 before the COVID-19 pandemic and ranged from 0.77 to 0.80 throughout the waves of the pandemic.

Conclusions:
We validated the use of the SOS score for sustained prescription opioid use following a diverse array of orthopaedic procedures across subspecialties. This tool is easy to implement for the purpose of prospectively identifying patients in musculoskeletal service lines who are at higher risk for sustained opioid use, thereby enabling the future implementation of upstream interventions and modifications to avert opioid abuse and to combat the opioid epidemic.

Level of Evidence:
Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Sagittal Alignment in Total Knee Arthroplasty
Authors: An Hao-Ming , Gu Wang , Nan Shao-Kui , Liu Zheng , Li Rui , Chai Wei 
Published: July 2023

Background:
Sagittal alignment determines the extension and flexion of knee prostheses in total knee arthroplasty (TKA). The definition of the sagittal axes may be different between the Mako TKA system (Stryker) and the conventional manual intramedullary approach. Whether there is any discrepancy between the 2 approaches has not been well studied.

Methods:
We retrospectively analyzed 60 full-length computed tomographic (CT) scans of the lower extremities of 54 patients. The femur and tibia were modeled by using Mimics (Materialise). The Mako mechanical axes were determined according to the Mako TKA Surgical Guide. The manual intramedullary axes were determined according to the central axis of the tibial proximal and femoral distal medullary cavities. The femoral, tibial, and combined angular discrepancies were measured in the sagittal plane.

Results:
On the femoral side, the Mako mechanical axis was more likely to be located in an extended position relative to the manual intramedullary axis (56 of 60 knees). The median angular discrepancy was 2.46° (interquartile range [IQR], 1.56° to 3.43° [range, −1.06° to 5.24°]). On the tibial side, the Mako mechanical axis was likely to be located in a flexed position relative to the manual intramedullary axis (57 of 60 knees). The median angular discrepancy was 2.40° (IQR, 1.87° to 2.84° [range, −0.79° to 4.20°]). The angular discrepancy of the femoral-tibial sagittal angle was 4.63° (IQR, 3.71° to 5.64° [range, 1.20° to 9.02°]).

Conclusions:
Compared with manual TKA, the Mako system is more likely to result in a decreased posterior tibial slope and extension of the femoral prosthesis. It may also influence the evaluation of lower-extremity extension and flexion. When using the Mako system, special attention should be given to these discrepancies.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.