bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysing the implementation of infection prevention and control measures in health care facilities during the COVID-19 pandemic in the African Region
Authors: Kabego Landry , Balde Thierno , Barasa Deborah , Ndoye Babacar , Hilde Okou-Bisso , Makamure Tendai , Mulumeoderwa Guy Ohirweoluhya , Kanyowa Trevor , Kamara Rashidatu , Hamadou Boiro , Ogundiran Opeayo , Okeibunor Joseph , Williams George , Tusiime Jayne Byakika , Atuhebwe Phionah Lynn , Oyugi Boniface , Mawanda Elande-Taty , Razakamanantsoa Andry , Braka Fiona , Chamla Dick , Gueye Abdou Salam 
Published: June 2023

Abstract
Background
The declaration of SARS-CoV-2 as a public health emergency of international concern in January 2020 prompted the need to strengthen infection prevention and control (IPC) capacities within health care facilities (HCF). IPC guidelines, with standard and transmission-based precautions to be put in place to prevent the spread of SARS-CoV-2 at these HCFs were developed. Based on these IPC guidelines, a rapid assessment scorecard tool, with 14 components, to enhance assessment and improvement of IPC measures at HCFs was developed. This study assessed the level of implementation of the IPC measures in HCFs across the African Region during the COVID-19 pandemic.
Method
An observational study was conducted from April 2020 to November 2022 in 17 countries in the African Region to monitor the progress made in implementing IPC standard and transmission-based precautions in primary-, secondary- and tertiary-level HCFs. A total of 5168 primary, secondary and tertiary HCFs were assessed. The HCFs were assessed and scored each component of the tool. Statistical analyses were done using R (version 4.2.0).
Results
A total of 11 564 assessments were conducted in 5153 HCFs, giving an average of 2.2 assessments per HCF. The baseline median score for the facility assessments was 60.2%. Tertiary HCFs and those dedicated to COVID-19 patients had the highest IPC scores. Tertiary-level HCFs had a median score of 70%, secondary-level HCFs 62.3% and primary-level HCFs 56.8%. HCFs dedicated to COVID-19 patients had the highest scores, with a median of 68.2%, followed by the mixed facilities that attended to both COVID-19 and non-COVID-19 patients, with 64.84%. On the components, there was a strong correlation between high IPC assessment scores and the presence of IPC focal points in HCFs, the availability of IPC guidelines in HCFs and HCFs that had all their health workers trained in basic IPC.
Conclusion
In conclusion, a functional IPC programme with a dedicated focal person is a prerequisite for implementing improved IPC measures at the HCF level. In the absence of an epidemic, the general IPC standards in HCFs are low, as evidenced by the low scores in the non-COVID-19 treatment centres.
Sagliker Syndrome: A case of Chronic Renal Failure with Uncontrolled Secondary Hyperparathyroidism
Authors: Gu Er-min , Xue Lingjie , Ye Xiaolan , Ru Yuefang 
Published: June 2023

Abstract
Man, 55-year-old, developed Sagliker syndrome (SS) in the course of hemodialysis for end-stage renal disease from 2008, as a result of uncontrolled secondary hyperparathyroidism (SHPT). His medical managements failed and he had no chance of kidney transplantation. Although surgical parathyroidectomy was rejected and the disease development could not be reversed, PTH began to decline and SS progressed slowly under the control of management and guidance in medication treatment. It is possible that such patients can survive with long-time dialysis, but the prevention of severe SHPT is critical.
Physiological ER stress caused by amylase production induces regulated Ire1-dependent mRNA decay in Aspergillus oryzae
Authors: Tanaka Mizuki , Zhang Silai , Sato Shun , Yokota Jun-ichi , Sugiyama Yuko , Kawarasaki Yasuaki , Yamagata Youhei , Gomi Katsuya , Shintani Takahiro 
Published: June 2023

Abstract
Regulated Ire1-dependent decay (RIDD) is a feedback mechanism in which the endoribonuclease Ire1 cleaves endoplasmic reticulum (ER)-localized mRNAs encoding secretory and membrane proteins in eukaryotic cells under ER stress. RIDD is artificially induced by chemicals that generate ER stress; however, its importance under physiological conditions remains unclear. Here, we demonstrate the occurrence of RIDD in filamentous fungus using Aspergillus oryzae as a model, which secretes copious amounts of amylases. α-Amylase mRNA was rapidly degraded by IreA, an Ire1 ortholog, depending on its ER-associated translation when mycelia were treated with dithiothreitol, an ER-stress inducer. The mRNA encoding maltose permease MalP, a prerequisite for the induction of amylolytic genes, was also identified as an RIDD target. Importantly, RIDD of malP mRNA is triggered by inducing amylase production without any artificial ER stress inducer. Our data provide the first evidence that RIDD occurs in eukaryotic microorganisms under physiological ER stress.
Summer and autumn tropical cyclone activity over South Korea responds in opposite ways to ENSO phases
Authors: Park Doo-Sun R. , Lee Chan-Ki , Chang Minhee , Park Tae-Won , Park Chang-Kyun 
Published: June 2023

Abstract
It is known that the El Niño Southern Oscillation (ENSO) is not a factor in the interannual variation of the number of tropical cyclones (TCs) affecting South Korea during the TC season, which generally includes both summer (July-August) and autumn (September-October). By dividing the TC season into two sub-seasons, i.e. summer and autumn, we found the opposite response of TC activity over South Korea to ENSO phases between the sub-seasons. In summer, a larger number of TCs influence South Korea during El Niño than during La Niña, while a smaller number of TCs do so in autumn. The opposite responses to ENSO could reduce the statistical significance of the relationship between ENSO and TC activity over South Korea when the entire TC season (July to October) is considered. In summer, the southerly anomaly over the southern sea of the Korean peninsula due to the eastward retreating subtropical high allows a greater number of TCs to approach South Korea during El Niño compared to La Niña. On the other hand, in autumn, the northwesterly anomaly due to the westward extension of the subtropical high leads to a smaller number of TC approaches.
Central Bank Communication about Climate Change
Authors: Arseneau David , Osada Mitsuhiro 
Published: June 2023

Abstract
This paper applies natural language processing to a large corpus of central bank speeches to identify those related to climate change. We analyze these speeches to better understand how central banks communicate about climate change. By all accounts, communication about climate change has accelerated sharply in recent years. The breadth of topics covered is wide, ranging from the impact of climate change on the economy to financial innovation, sustainable finance, monetary policy, and the central bank mandate. Financial stability concerns are touched upon, but macroprudential policy is rarely mentioned. Direct central bank action largely revolves around identifying and monitoring potential risks to the financial system. Finally, we find that central banks tend to use speculative language more frequently when talking about climate change relative to other topics.
JEL Classifications: E58; E61; Q54
Insights into chitosan-cleaving enzymes by simultaneous analysis of polymers and oligomers via SEC-RI-ESI-MS
Authors: Hellmann Margareta J. , Moerschbacher Bruno M. , Cord-Landwehr Stefan 
Published: June 2023

Abstract
The detailed characterization of chitosan-cleaving enzymes is of great importance to unveil structure-function relationships of this promising class of biomolecules, both for enzymatic fingerprinting analyses and to use the enzymes as biotechnological tools for the production of tailor-made chitosans for diverse applications. Analyzing polymeric substrates as well as oligomeric products has proven a suitable way to understand the enzymes’ actions but currently, this requires separate, rather laborious methods to obtain the full picture. Here, we describe size exclusion chromatography coupled to refractive index and electrospray ionization mass spectrometry detection (SEC-RI-ESI-MS) as a simple and fast way to semi-quantitatively analyze chitosan oligomers and to concomitantly determine the average molecular weight and its distribution for chitosan polymers. By sampling live from an ongoing enzymatic reaction, SEC-RI-ESI-MS offers the unique opportunity to analyze polymers and oligomers simultaneously – i.e. to follow the reduction in molecular weight of the polymeric substrate over the course of the digestion, while at the same time analyzing the emerging oligomeric products in a quantitative manner. In this way, a single simple analysis yields detailed insights into an enzyme’s action on a given substrate.
Addition of logging residues short-term affects basic soil parameters and soil organic carbon in six types of urban plantations
Authors: Xing Honglin , Zhang Hao , Tang Guoru , Yuan Tianhe , Wang Ruirui , Shen Hailong , Yang Ling 
Published: June 2023

Abstract

Different treatments of logging residues can impact on the forest soil carbon pool, but the short-term effects are still unclear. This study aimed to the relationship between the changes of the addition of logging residues and different tree species soil organic carbon content and basic soil parameters. The experimental site was located in Harbin, China, and four logging residue addition levels were set under six forest types, converted to carbon added as 0, 250 (low carbon addition, LC), 500 (medium carbon addition, MC) and 1000 (high carbon addition, HC) g/m2. In the short-term (five months), the logging residues partially decomposed, but the effect on basic soil parameters was small. Soil organic carbon, microbial carbon, and dissolved organic carbon increased significantly in the 0–10 cm soil layer for some tree species, and not significantly in the 10 –20 cm soil layer. There is no consistent relationship between the addition of logging residues and soil parameters under different tree species. That adding logging residues could increase soil carbon pool, there were treespeciesspecific differences in the dynamics of soil processes.
Prognostic Impact of Neoadjuvant Chemotherapy in Gallbladder Cancer: a Population- Based and Propensity Score Matched SEER Analysis
Authors: Xiong Yichen , Yang Zi-yi , Gong Albie , Wu Zi-you , Liu Shi-lei , Zhu Yi-di , Song Xiao-ling , Chu Bing-feng , Wu Xiang-song , Gong Wei 
Published: June 2023

Abstract
Background:
The effect of neoadjuvant chemotherapy (NACT) in gallbladder cancer (GBC) patients remains controversial. The aim of this study was to assess the impact of NACT on overall survival (OS), cancer specific survival (CSS), and to explore possible protective predictors for prognosis.
Methods:
GBC patients’ data were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Patients in the NACT and non-NACT groups were propensity score matched (PSM) 1:3, the Kaplan-Meier method and log-rank test were performed to analyze the impact of NACT on OS and CSS. Univariable and multivariable Cox regression models were applied to identify the possible prognostic factors.
Results:
Of the 5,003 cases diagnosed as stage I-III GBC according to AJCC 8th TNM stage, 64 NACT and 192 non-NACT patients remained after PSM. In all GBC patients, the median OS of the NACT and non-NACT was 31 and 20 months (log-rank P＜0.001), and the median CSS of NACT and non-NACT was 31 and 24 months (log-rank P=0.002). While in advanced GBC patients, the median OS of the NACT and non-NACT groups were 27 and 16 months (log-rank P＜0.001), respectively, and the median CSS of the NACT and non-NACT groups were 27 and 19 months (log-rank P=0.006), respectively. Multivariable Cox regression analysis showed that NACT, lymph node dissection (LND) and surgery type were positive protective factors for OS and CSS in GBC patients.
Conclusions:
Patients receiving NACT had significantly better survival than those that did not. NACT may provide therapeutic benefits for GBC patients, especially for those at an advanced stage. NACT combined with radical surgery improved the survival time of GBC patients. Therefore, NACT combined with surgery may provide a better treatment option for advanced GBC patients.
Using Video Analysis and Artificial Intelligence Techniques to Explore Association Rules and Influence Scenarios in Elite Table Tennis Matches
Authors: Liu Jing-Wei , Hsu Ming-Hua , Lai Chun-Liang , Wu Sheng-K 
Published: June 2023

Abstract

To become an elite table tennis player, aside from continually practicing, players must know their strengths and weaknesses to plan their strategy beforehand and increase their rate of winning. The main problems with previous research are that the data collected were incomplete and imprecise. To address these problems, we established” The Intellectual Tactical System in Competitive Table Tennis”, using video analysis to collect competitive data. And, we proposed a machine learning method using a combination of feature-selection and association rules to discover interesting rules from the data. The international matches of the Taiwanese table tennis single player Yun-Ju Lin were used as research samples by applying 3S (speed, spin, spot) theory to collect and analyze data. The critical factors and scenarios were analyzed to identify the winning tactical models. The results of this study may provide useful suggestions for Yun-Ju Lin on training and building tactics in competitions.
Winter precipitation predictability in Central Southwest Asia and its representation in seasonal forecast systems
Authors: Kucharski Fred , Johnson Nathaniel , Ashfaq Moetasim , Horan Mathew 
Published: June 2023

Abstract
In Central Southwest Asia (CSWA), winter precipitation contributes significantly to the annual mean, but substantial interannual variations exist. Dynamical models exhibit subpar predictability in this region, but it still needs to be established what limits their skills. Here, we identify the major tropical and extratropical forcings that explain three-fourths of area-averaged seasonal variability in CSWA winter precipitation. Tropical forcing comes from the indirect ENSO pathway, the leading mode of precipitation variability in the tropical Indian Ocean. This precipitation mode is coupled with ENSOrelated sea surface temperature variability in the Pacific Ocean. A direct ENSO influence on CSWA does not extend beyond its Indian Ocean connection. Extratropical forcing comes from a large-scale mode arising from internal atmospheric variability. The spatial structure, interannual variability of tropical forcing, and its teleconnection with CSWA winter precipitation are skillfully depicted in two seasonal forecasting systems, SEAS5 and SPEAR. Extratropical forcing spatial structure is also produced skillfully in the two modeling systems; however, the representation of its interannual seasonal variability and teleconnection with CSWA winter precipitation require improvements. While SEAS5 displays reasonable skill in representing extratropical forcing influence on CSWA winter precipitation and marginal skill in reproducing interannual seasonal variability, SPEAR has negligible ability in both areas. Consequently, these models have limited predictive skills over CSWA in winter. While improvements in representing extratropical forcing in dynamical models may be inherently limited as it primarily arises from internal
Gender difference in the association between sensitivity to thyroid hormones with incident high remnant cholesterol levels in euthyroid adults
Authors: Guo Wen , Lu Jing , Li Xiaona , Zhu Wenfang , Xu Nianzhen , Jia Jue , Zhang Qun 
Published: June 2023

Abstract
Background
Whether resistance to thyroid hormones affect the atherogenic remnant cholesterol (RC) levels remains unknown. The aim of this study was to explore the association of sensitivity to thyroid hormones with the incident high RC levels in euthyroid Chinese adults and further explore this association was modified by gender differences.
Methods
We performed a post hoc analysis including eligible participants from the 11223 who underwent at least two health examinations and were with RC < 0.8 at baseline from 2006 to 2010. Central and peripheral sensitivity to thyroid hormones such as thyroid-stimulating hormone index (TSHI) and thyrotrophic thyroxine resistance index (TT4RI), thyroid feedback quantile-based index (TFQI) and free triiodothyronine (FT3)/free thyroxine (FT4) were calculated.
Results
Participants with RC levels had higher levels of TSHI ,TT4RI and TFQI than participants in the normal RC group in females. However, there were no differences of TSHI, TT4RI, TFQI and FT3/FT4 between the normal RC group and the high RC group in males. In the multi-adjusted models, the highest tertiles (tertiles 3) of TSHI was associated with an increased high RC levels risk compared with the lowest tertiles (tertiles 1) (HR = 1.819, 95%CI 1.268–2.607, P = 0.001) in females. The association was also significant using TT4RI and TFQI as indices of central sensitivity to thyroid hormones in females. In stratified analyses, the relationship between thyroid hormone sensitivity and incident high RC levels was statistically significant in women < 48 years old, but not in ≥ 48 years old.
Conclusion
High TSHI ,TT4RI and TFQI increase risk of incident high RC levels in euthyroid Chinese adults in females, suggesting that central resistance of thyroid hormones may participant in the pathophysiological process of high RC levels.
Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3-(2H) Dione Moiety as potential antioxidant, antimicrobial, and anticancer
Authors: Jabbour Mirna , Al-Khayat Mohammad Ammar , Murad Hossam , Ktaifani Mahmoud Al 
Published: June 2023

AbstractPurpose:To synthesize new Isoindole-1,3-(2H) Dione derivatives by molecular hybridization of Gabapentin, and Pregabalin with phthalic anhydride derivatives, and to evaluate their biological activity as promising antioxidant, antimicrobial, and anticancer agents.Method:Molecular hybridization was successfully achieved by two procedures; synthesized compounds were characterized using analytical and spectral methods. Free radical scavenging properties of synthesized compounds were evaluated using DPPH method. Antibacterial activity of synthesized compounds, and parent compounds was evaluated against two microbial gram-positive and gram-negative strains by well diffusion method. Furthermore, we have studied effect of compounds on proliferation, cell cycle and cell death of two human cancer cell lines (Caco-2 and HCT-116).Results:Compounds1,3,4exhibited good free radical scavenging effect, compound3is the most effective with IC50value 2.525 µmol/mL. All Compounds showed antibacterial activity against E. coli and Staphylococcus Aureus related to concentration while parent drugs did not exhibit any antibacterial effect. Compounds1and2showed good zone of inhibition against Escherichia Coli at micromolar concentrations, and they are more effective than gentamycin sulfate. Treatment with studied compounds suppresses proliferation, arrests progress throughout the cell cycle and induces apoptosis in Caco-2 and HCT-116 cancer cells. Compound2is highly effective against Caco-2 cells and more effective than Thalidomide, with IC50value less than 1 µmol/L.Conclusion:Our results showed that molecular hybridization of Gabapentin, and Pregabalin in Isoindole-1,3(2H) Dione moiety result in promising anti-cancer and antimicrobial molecules. Results of this preliminary study show that halogenation of Isoindole-1,3-(2H) dione moiety improves antimicrobial, and anticancer activity, and that tetra-brominated derivatives are comparable or more effective than related tetra-chlorinated derivatives.
Hsa-miR-34b-3p alleviates sepsis by relieving autoimmunosuppressive effects of ADRB2
Authors: Fu Lin , Chen Jie , Zheng Anfu , Zhang Duoli , Xiao Mintao , Zhao Yueshui , Wu Xu , Li Mingxing , Du Fukuan , Chen Yu , Shen Jing , Deng Shuai , Xiao Zhangang 
Published: June 2023

AbstractObjectiveIn this study, we aimed to identify the key microRNAs (miRNAs) and potential target genes through bioinformatics analysis, and investigate the underlying mechanisms of sepsis.Materials and MethodsWe collected miRNA expression profiles from sepsis patients and healthy individuals, screened differentially expressed miRNAs (DEMs) between sepsis patients and healthy individuals by bioinformatics analysis, and constructed miRNA-mRNA regulatory networks using online databases. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was used to annotate the biological functions and pathways of the genes. Single Sample Gene Set Enrichment Analysis (ssGSEA) assessed immunological characteristics in sepsis samples. Single cell sequencing (scRNA-seq) data were used to discover gene expression in different cell clusters.ResultsFour miRNAs were significantly differentially expressed in sepsis patients compared to healthy controls, with hsa-miR-34b-3p, hsa-miR-3663-3p and hsa-miR-4446-5p upregulated and hsa-miR-625-5p downregulated. ADRB2 may be a potential target of hsa-miR-34b-3p, and DisGeNET database showed that ADRB2 may be related to sepsis. Receiver operating characteristic (ROC) analysis suggested that ADRB2 has potential as a diagnostic marker for sepsis. The ssGSEA result showed that ADRB2 expression was positively correlated with T cell co-inhibition, and negatively correlated with dendritic cell infiltration. ScRNA-seq data showed that ADRB2 expression was increased in natural killer (NK) cells and natural killer T (NKT) cells in sepsis patients in contrast to healthy controls.ConclusionADRB2 may suppress the autoimmunity of patients with sepsis, thus aggravating sepsis. It can be used as a new diagnostic biomarker and molecular therapeutic target. Hsa-miR-34b-3p can inhibit the expression of ADRB2, relieve its immunosuppressive effect and alleviate sepsis to a certain extent.