bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding language processing in variable populations on their own terms: Towards a functionalist psycholinguistics of individual differences, development, and disorders
Authors: McMurray Bob , Baxelbaum Keith S. , Colby Sarah , Bruce Tomblin J. 
Published: May 2023

AbstractClassic psycholinguistics seeks universal language mechanisms for all people, emphasizing the “modal” listener: hearing, neurotypical, monolingual, and young adults. Applied psycholinguistics then characterizes differences in terms of their deviation from the modal. This mirrors naturalist philosophies of health which presume a normal function, with illness as a deviation. In contrast, normative positions argue that illness is partially culturally derived. It occurs when a person cannot meet socio-culturally defined goals, separating differences in biology (disease) from socio-cultural function (illness). We synthesize this with mechanistic functionalist views in which language emerges from diverse lower-level mechanisms with no one-to-one mapping to function (termed the functional mechanistic normative approach). This challenges primarily psychometric approaches—which are culturally defined—suggesting a process-based approach may yield more insight. We illustrate this with work on word recognition across multiple domains: cochlear implant users, children, language disorders, L2 learners, and aging. This work investigates each group’s solutions to the problem of word recognition as interesting in its own right. Variation in the process is value-neutral, and psychometric measures complement this, reflecting fit with cultural expectations (disease vs. illness). By examining variation in processing across people with a variety of skills and goals, we arrive at deeper insight into fundamental principles.
Environmental Factors in Nursing Workplaces that Promote Resilience during Pandemics: Scoping Review
Authors: Witt Regina Rigatto , Jung Walnice , da Paixão Miguel Lucas Silva , Cusack Lynette 
Published: May 2023

AbstractAim:This scoping review explored the main environmental factors in the workplace that contribute to nursing resilience in respiratory infectious pandemic events.Background:There is strong evidence in the literature about the influence of individual factors on nurses’ resilience and a growing interest on the impact of the workplace environment on these factors. Therefore, a review that synthesizes environmental factors that support nurses’ resilience in pandemic events is timely.Method:A scoping review of publications written in English, Spanish, and Portuguese of registered publications until December 2020 in MEDLINE, Embase, PubMed, Scopus, SciELO, CINAHL, WoS, BVS, and APA identified 10,767 potential papers. Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines were used during the literature review process. The Health Services Workplace Environmental Resilience Model (HSWERM) was used to guide exploration and synthesis.Results:Thirty-two (32) publications met inclusion criteria. Most of the HSWERM workplace factors were mentioned in the literature. The main workplace environmental factors that were identified included communication, inter-professional collaboration, access to equipment, targeted training, and supporting well-being.Conclusions:Recognition of these key environmental factors in the workplace will help to implement more effective actions to promote resiliency prior to and during emergency situations. It will also enable managers to include, in any preparation planning, contingencies to protect these factors with the view of sustainable resilience of nursing staff throughout the emergency event.
First-Week Analysis after the Turkey Earthquakes: Demographic and Clinical Outcomes of Victims
Authors: Sarı Hıdır , Özel Mehmet , Akkoç Mehmet Fatih , Şen Abdullah 
Published: May 2023

AbstractBackground:During a major earthquake, escape attempts or collapsed buildings can result in injury, disability, and even death for victims. The aim of this study is to examine the demographic characteristics, clinical outcomes, and injuries of victims admitted to the emergency department within the first week after an earthquake.Methods:This is a retrospective observational study conducted on earthquake victims who were admitted to the emergency services of a tertiary medical faculty and a training and research hospital in the city of Diyarbakir, located in the Southeastern Anatolia Region of Turkey, from February 6 through February 12, 2023.Results:Of the eligible 662 earthquake victims, the mean age was 10.66 (SD = 4.78 [min 0, max 17]) in children, 36.87 (SD = 4.78 [min 18, max 63]) in adults, and 72.85 (SD = 5.83 [min 65, max 84]) in the elderly. Women constituted 52.8% of the victims, 19.7% were children, and 8.0% were elderly. Sixty-one percent (61.0%) of earthquake victims were admitted to emergency services in the first three days following the disaster; 37.7% of all victims were transferred from other affected cities to Diyarbakır. In all, 80.2% of the victims were admitted as survivors to the emergency services (36.8% were rescued under rubble, 40.1% with injuries while attempting to escape the earthquake, and 3.3% with nontraumatic reasons) and 19.8% were deceased under rubble. The majority of the 131 deceased victims were women (52.7%), 20.6% were children, and 7.6% were elderly. An estimated 38.3% of victims were hospitalized (20.9% in the ward and 17.4% in the intensive care unit [ICU]). For all age groups that survived under the rubble, the extremities were most injured (53.6% for children, 53.1% for adults, and 55.5% for the elderly). Of adult survivors, 26.6% needed only fluid therapy, renal replacement treatment (hemodialysis) was required 20.7%, and 11.8% required amputation. Of children survivors under the rubble, renal replacement treatment (hemodialysis) was required for only four, seven required amputation, and 12 needed only fluid resuscitation for crush injury. Of elderly survivors, two needed only fluid therapy, renal replacement treatment (hemodialysis) was required for two, and no amputation was required. Six patients survived under the rubble and died in the ICU.Conclusion:The definition of the demographic characteristics and clinical outcomes of earthquake patients is critical to the development of preparedness, response, and recovery policies for future disasters.
Genetic variability, trait inter-relationships, third and fourth degree statistics based genetics for fruit quality and yield traits governing shelf life in tomato (Solanum lycopersicum L.)
Authors: Pavan M. P. , Gangaprasad S. , Adivappar Nagarajappa 
Published: May 2023

AbstractKnowledge on genetic architecture and inheritance of tomato shelf life contributing traits in different genetic backgrounds is a key issue for shelf life improvement. An investigation was undertaken to estimate the nature and magnitude of variability, traits inter-relationships, third and fourth degree statistics to unravel the genetics of 18 fruit quality and yield traits governing shelflife in F2 population of ‘Arka Vikas’ × ‘Red ball’ cross. The wider standardized range and higher estimates of phenotypic coefficient of variation indicated prevalence of adequate variability for fruit quality and yield traits. Fruit firmness and pericarp thickness ranged from 1.20–3.44 kg/cm2 and 2.44–5.31 mm respectively. Pulp content and shelflife ranged from 58.59–94.70% and 10.60–26.40 days respectively. Significant positive correlation with direct effect on fruit shelf life was exhibited by fruit firmness, pericarp thickness, TSS, titratable acidity, pulp content, fruit length and locule number. Positive skewness with platykurtic distribution recorded for TSS, lycopene, ascorbic acid, titratable acidity, fruit length, weight, pericarp thickness, plant height and number of branches. Negatively skewed with platykurtic distribution observed for pH, fruit diameter, firmness, pulp content, locule number, shelf life and number of clusters which signified duplicate epistasis of dominant genes in traits inheritance. The transgressive segregants for fruit quality traits indicated complementary effects of dispersed allele combinations between parents. Additive and dominance components could be exploited in the advanced segregating population by evaluating large number of families. In addition to additive effects, predominance of dominance effects of genes are important in inheritance of fruit quality traits governing shelflife.
Roles of obesity in mediating the causal effect of attention-deficit/hyperactivity disorder on diabetes
Authors: Liu Ningning , Tan Jiang-Shan , Liu Lu , Li Haimei , Wang Yufeng , Yang Yanmin , Qian Qiujin 
Published: May 2023

Abstract

Aims
Previous observational studies have reported potential associations among attention-deficit/hyperactivity disorder (ADHD), obesity, and diabetes (including type 1 and type 2 diabetes mellitus [T1DM/T2DM]). However, whether the association between ADHD and diabetes is mediated by obesity is unknown.

Methods
With two-sample Mendelian randomization, we analysed the causal effect of ADHD on T1DM and T2DM and six obesity-related traits [including body mass index, waist circumference (WC), hip circumference, waist-to-hip ratio (WHR), body fat percentage and basal metabolic rate] and the causal effect of these obesity-related traits on T1DM/T2DM. Finally, with multivariable Mendelian randomization, we explored and quantified the possible mediation effects of obesity-related traits on the causal effect of ADHD on T1DM/T2DM.

Results
Our results showed that ADHD increased the risk of T2DM by 14% [odds ratio (OR) = 1.140, 95% confidence interval (CI) = 1.005–1.293] but with no evidence of an effect on T1DM (OR = 0.916, 95% CI = 0.735–1.141, P = 0.433.). In addition, ADHD had a 6.1% increased causal effect on high WC (OR = 1.061, 95% CI = 1.024–1.099, P = 0.001) and an 8.2% increased causal effect on high WHR (OR = 1.082, 95% CI = 1.035–1.131, P = 0.001). In addition, a causal effect of genetically predicted high WC (OR = 1.870, 95% CI = 1.594–2.192, P < 0.001) on a higher risk of T2DM was found. In further analysis, WC mediated approximately 26.75% (95% CI = 24.20%–29.30%) of the causal association between ADHD and T2DM.

Conclusions
WC mediates a substantial proportion of the causal effect of ADHD on the risk of T2DM, which indicated that the risk of T2DM induced by ADHD could be indirectly reduced by controlling WC as a main risk factor.
Linking the Core Heat Content to Earth's Accretion History
Authors: Clesi Vincent , Deguen Renaud 
Published: May 2023

AbstractIn this study we use a parameterized model of differentiation in a magma ocean setting, in which the magma ocean depth evolves during accretion, to predict the composition of the primordial core. We couple this chemical model to a thermal evolution model of the accreting metal to estimate the Earth's core heat content at the end of its formation. We find geochemically consistent models. All these scenarios have in common two key features: (a) the average pressure of metal‐silicates equilibration is between 20 and 45 GPa (final pressure between 40% and 60% of CMB pressure); (b) 60%–80% of Earth's mass is accreted as reduced material. The chemical stratification is stable in most cases, though some scenarios result in an unstable compositional stratification. Mixing an initially stratified core requires a small fraction of the energy released after a giant impact. Importantly, the temperature at the Core Mantle Boundary is ranging from 3925 to 4150 K. For example, scenarios in which the magma ocean remains shallow for a large part of the accretion, then gets deeper at the end of accretion can produce chemically coherent models with cooler cores. This suggests that independent constraints on the core temperature could in principle be used as constraints for the differentiation conditions, and core composition. In particular, we find that the abundance of light elements in the core correlates positively with the temperature of the core at the end of accretion, as well as with the average pressure of equilibration during differentiation.
Linking Snow, Soil, and Stream During Snowmelt and Rain‐On‐Snow Events: Storage and Transport of Ions in an Acid‐Sensitive Alpine Catchment (Tatra Mountains, Poland)
Authors: Siwek J. P. , Wasak‐Sęk K. , Bryła M. , Jelonkiewicz Ł. , Żelazny M. 
Published: May 2023

AbstractThe purpose of the study was to examine the storage and transport ofions through snowpack, soils, and stream water in an acid‐sensitive alpine catchment (Tatra Mountains, Poland) during snowmelt and rain‐on‐snow events. Samples of snowpack layers, near‐surface soil horizons, and stream water were collected in the winter and snowmelt seasons of 2019. A laboratory experiment was conducted to determine the effect of temperature on the rate of soil nitrogen mineralization and nitrification. Our study has shown that snowpack is an important source ofions in the catchment. As the snow melts, the release ofions from snowpack occurs. A gradual and slow melting of snow starts even before the first snowmelt‐induced increase in stream discharge.ions eluted from available snowpack are temporarily stored in soil, which is shown by a large increase in the concentration of water‐solublein the soil at that time.ions are washed out of soils and supplied to streams during the first snowmelt event. This is demonstrated by a large increase in the stream waterconcentration, termed an “pulse.” Theion is a key acid anion responsible for the acidification of the studied stream during snowmelt season, as thepulse coincides with a decrease in bicarbonate alkalinity. Our field research and laboratory experiment have shown a minor role of mineralization and nitrification inproduction in soils in the winter andpulse formation in stream water during the early stages of the snowmelt season.
Modeling Seismic Anisotropy Beneath the Island of Hispaniola via the Harmonic Decomposition of Receiver Functions
Authors: Kumar Sachin , Agrawal Mohit , Pulliam Jay 
Published: May 2023

AbstractThe Caribbean Island of Hispaniola resulted from plate convergence that brought together distinct terranes and may include one or more active microplates. These processes may have brought seismically anisotropic materials to the island or created anisotropic structures through deformation. Our goal is to identify and model interfaces that bound seismically anisotropic media and/or dipping interfaces between isotropic layers beneath Hispaniola and assess the implications of our results for the region's tectonics. We perform harmonic decomposition of receiver function gathers for 17 broadband seismic stations deployed on the island. Our results reveal (a) a layer bounded by interfaces that produce opposite polarity on the transverse receiver functions at 25 and 41 km depth in the northern and eastern Dominican Republic that corresponds to the subducting North American oceanic lithosphere, (b) a layer at ∼8–17 km depth (also bounded by interfaces that produce opposite polarity) beneath the Cordillera Central in the central and eastern parts of the island that may indicate the crystalline, well‐differentiated lower crust of this long‐lived terrane, and (c) an interface that bounds anisotropic material at 22 km depth beneath southwestern Hispaniola. This last interface may correspond to the underthrusting Caribbean Large Igneous Province (CLIP), in which case it would mark the CLIP's upper boundary and the lower boundary is too gradual a transition to produce conversions.
Effect of Freshwater Discharge From Estuary Dam on Residual Circulation in Bifurcated Channel
Authors: Kim J. W. , Song J. I. , Yoon B. I. , Woo S.‐B. 
Published: May 2023

AbstractThe residual structure of the inner part of the Yeongsan River estuary has been reported to be a multi‐layer vertical structure, unlike the two‐layer vertical structure of a typical estuary, due to irregular freshwater discharge. The inner estuary has a main channel connected to the open sea, and a bifurcated channel system (sub‐channel) in its central part, which can affect the residual current. In this study, field observations of three‐dimensional velocity and salinity were conducted to understand the discharge effects on the residual current at bifurcated channels. The residual flows were estimated using least‐squares harmonic analysis. The relative contributions of advection acceleration and friction terms to nonlinear effects were evaluated using along‐channel momentum balance. In the absence of freshwater discharge, the flow patterns were dominated by tidal dynamics in the sub‐channel rather than the main channel, whereas most flow patterns during freshwater discharge were dominated by near‐surface strong velocity in the main channel. A multi‐layer vertical residual structure was observed during the non‐discharge period in the main channel, which was caused by the insertion of upstream residual flow from the sub‐channel. Nonlinear effects occurred at the bifurcation point of the two channels. During the non‐discharge period, the advection term was most dominant, whereas the vertical friction term was dominant during the discharge period. Moreover, the magnitude of the horizontal friction term was larger than that of the advection term. Therefore, freshwater discharge can lead to an increase in the friction term, which in turn can markedly affect the residual circulation.
Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL
Authors: Bryant Dean , Smith Lindsay , Rogers-Broadway Karly Rai , Karydis Laura , Woo Jeongmin , Blunt Matthew D. , Forconi Francesco , Stevenson Freda K. , Goodnow Christopher , Russell Amanda , Humburg Peter , Packham Graham , Steele Andrew J. , Strefford Jonathan C. 
Published: May 2023

AbstractChronic lymphocytic leukaemia (CLL) cells can express unmutated (U-CLL) or mutated (M-CLL) immunoglobulin heavy chain (IGHV) genes with differing clinical behaviours, variable B cell receptor (BCR) signalling capacity and distinct transcriptional profiles. As it remains unclear how these differences reflect the tumour cells’ innate pre/post germinal centre origin or their BCR signalling competence, we applied mRNA/miRNA sequencing to 38 CLL cases categorised into three subsets by IGHV mutational status and BCR signalling capacity. We identified 492 mRNAs and 38 miRNAs differentially expressed between U-CLL and M-CLL, but only 9 mRNAs and 0 miRNAs associated with BCR competence within M-CLL. Of the IGHV-associated miRNAs, (14/38 (37%)) derived from chr14q32 clusters where all miRNAs were co-expressed with theMEG3lncRNA from a cancer associated imprinted locus. Integrative analysis of miRNA/mRNA data revealed pronounced regulatory potential for the 14q32 miRNAs, potentially accounting for up to 25% of the IGHV-related transcriptome signature.GAB1, a positive regulator of BCR signalling, was potentially regulated by five 14q32 miRNAs and we confirmed that two of these (miR-409-3p and miR-411-3p) significantly repressed activity of theGAB13′UTR. Our analysis demonstrates a potential key role of the 14q32 miRNA locus in the regulation of CLL-related gene regulation.
Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome
Authors: Cheng Robert Y. S. , Ridnour Lisa A. , Wink Adelaide L. , Gonzalez Ana L. , Femino Elise L. , Rittscher Helene , Somasundaram Veena , Heinz William F. , Coutinho Leandro , Rangel M. Cristina , Edmondson Elijah F. , Butcher Donna , Kinders Robert J. , Li Xiaoxian , Wong Stephen T. C. , McVicar Daniel W. , Anderson Stephen K. , Pore Milind , Hewitt Stephen M. , Billiar Timothy R. , Glynn Sharon A. , Chang Jenny C. , Lockett Stephen J. , Ambs Stefan , Wink David A. 
Published: May 2023

AbstractA strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER breast cancer has been established. However, the mechanisms of tumor induction of these enzymes are unclear. Analysis of The Cancer Genome Atlas (TCGA) revealed correlations between NOS2 and COX2 expression and Th1 cytokines. Herein, single-cell RNAseq analysis of TNBC cells shows potent NOS2 and COX2 induction by IFNγ combined with IL1β or TNFα. Given that IFNγ is secreted by cytolytic lymphocytes, which improve clinical outcomes, this role of IFNγ presents a dichotomy. To explore this conundrum, tumor NOS2, COX2, and CD8+ T cells were spatially analyzed in aggressive ER–, TNBC, and HER2 + breast tumors. High expression and clustering of NOS2-expressing tumor cells occurred at the tumor/stroma interface in the presence of stroma-restricted CD8+ T cells. High expression and clustering of COX2-expressing tumor cells extended into immune desert regions in the tumor core where CD8+ T cell penetration was limited or absent. Moreover, high NOS2-expressing tumor cells were proximal to areas with increased satellitosis, suggestive of cell clusters with a higher metastatic potential. Further in vitro experiments revealed that IFNγ + IL1β/TNFα increased the elongation and migration of treated tumor cells. This spatial analysis of the tumor microenvironment provides important insight into distinct neighborhoods where stroma-restricted CD8+ T cells exist proximal to NOS2-expressing tumor niches that could have increased metastatic potential.
Community concerns about genetic discrimination in life insurance persist in Australia: A survey of consumers offered genetic testing
Authors: Tiller Jane , Bakshi Andrew , Dowling Grace , Keogh Louise , McInerney-Leo Aideen , Barlow-Stewart Kristine , Boughtwood Tiffany , Gleeson Penny , Delatycki Martin B. , Winship Ingrid , Otlowski Margaret , Lacaze Paul 
Published: May 2023

AbstractFears of genetic discrimination in life insurance continue to deter some Australians from genetic testing. In July 2019, the life insurance industry introduced a partial, self-regulated moratorium restricting the use of genetic results in underwriting, applicable to policies up to certain limits (eg AUD$500,000 for death cover).We administered an online survey to consumers who had taken, or been offered, clinical genetic testing for adult-onset conditions, to gather views and experiences about the moratorium and the use of genetic results in life insurance, including its regulation.Most respondents (n = 367) had undertaken a genetic test (89%), and had a positive test result (76%; n = 243/321). Almost 30% (n = 94/326) reported testing after 1 July 2019. Relatively few respondents reported knowing about the moratorium (16%; n = 54/340) or that use of genetic results in life insurance underwriting is legal (17%; n = 60/348). Only 4% (n = 14/350) consider this practice should be allowed. Some respondents reported ongoing difficulties accessing life insurance products, even after the moratorium. Further, discrimination concerns continue to affect some consumers’ decision-making about having clinical testing and applying for life insurance products, despite the Moratorium being in place. Most respondents (88%; n = 298/340) support the introduction of legislation by the Australian government to regulate this issue.Despite the introduction of a partial moratorium in Australia, fears of genetic discrimination persist, and continue to deter people from genetic testing. Consumers overwhelmingly consider life insurers should not be allowed to use genetic results in underwriting, and that federal legislation is required to regulate this area.