bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fourth ventricular subarachnoid stent for Chiari malformation type I–associated persistent syringomyelia
Authors: Han Rachael K. , Medina Mauricio P. , Giantini-Larsen Alexandra M. , Chae John K. , Cruz Amanda , Garton Andrew L. A. , Greenfield Jeffrey P. 
Published: March 2023

OBJECTIVE
Syringomyelia (syrinx) associated with Chiari malformation type I (CM-I) is commonly managed with posterior fossa decompression, which can lead to resolution in most cases. A persistent syrinx postdecompression is therefore uncommon and challenging to address. In the setting of radiographically adequate decompression with persistent syrinx, the authors prefer placing fourth ventricular subarachnoid stents that span the craniocervical junction particularly when intraoperative observation reveals arachnoid plane scarring. The objective of this study was to evaluate the safety and efficacy of a fourth ventricle stent for CM-I–associated persistent syringomyelia, assess dynamic changes in syrinx dimensions, and report stent-reduction durability, clinical outcomes, and procedure-associated complications.

METHODS
The authors performed a single-institution, retrospective review of patients who underwent fourth ventricular subarachnoid stent placement for persistent CM-I–associated syringomyelia following a prior posterior fossa decompression. The authors’ institutional Chiari database contains 600 cases with 149 decompressions for CM-I–associated syringomyelia, of which 13 met criteria for inclusion. Data on patient demographics, clinical presentation and outcomes, and MRI findings were collected. The maximal syrinx diameter was estimated by calculating the area of an elliptical cross-section in the largest axial plane from preoperative, immediately postoperative, and late postoperative T2-weighted MR images.

RESULTS
All 13 patients experienced a significant decrease in mean syrinx area from the preoperative to the late postoperative MRI (mean syrinx diameter 114.1 ± 81.8 mm2 vs 24.5 ± 23.8 mm2, p < 0.001). The mean time until late postoperative MRI was 19.7 months (range 2.0–70.7 months). The syrinx area reduced on average by 75.0% ± 23.9% at the time of the last postoperative scan. Syrinx resolution was variable, with 4 patients (30.8%) achieving near-complete resolution (> 90%, grade III reduction), 7 patients (50%) having 50%–90% reduction (grade II), and 2 patients (14.3%) having < 50% decrease (grade I). One patient experienced catheter migration into the left brachium pontis with an associated cyst at the tip of the catheter that decreased in size on follow-up imaging.

CONCLUSIONS
Placement of fourth ventricular subarachnoid stents spanning the craniocervical junction in patients with persistent CM-I–associated syringomyelia after posterior fossa decompression is a safe therapeutic option and significantly reduced the mean syrinx area, with a greater reductive effect seen over longer follow-up periods.
Central or axial atlantoaxial dislocation and craniovertebral junction alterations: a review of 393 patients treated over 12 years
Authors: Shah Abhidha , Vutha Ravikiran , Prasad Apurva , Goel Atul 
Published: March 2023

OBJECTIVE
The authors reviewed their scientific publications and updated their clinical material obtained over the last 12 years for cases of central or axial atlantoaxial dislocation (CAAD) identified in the presence of craniovertebral musculoskeletal and/or neural alteration(s). The management implications of diagnosing and treating CAAD are highlighted.

METHODS
During a 12-year period, CAAD was diagnosed in 393 patients with craniovertebral junction–related musculoskeletal and neural alterations who underwent atlantoaxial fixation. No bone decompression was done. All CAAD-related craniovertebral junction structural changes were identified to have a naturally protective role. Hence, in this paper the term "craniovertebral alterations" is used for "craniovertebral junction anomalies" and the term "Chiari formation" is used instead of the commonly used term "Chiari malformation."

RESULTS
The major radiological diagnosis was determined either singly or in cohort with one or more of other so-called pathological entities that included Chiari formation (367 cases), syringomyelia with Chiari (306 cases), idiopathic syringomyelia (12 cases), type B basilar invagination (147 cases), bifid arch of the atlas (9 cases), assimilation of the atlas (119 cases), C2–3 fusion (65 cases), Klippel-Feil alteration (4 cases), and dorsal kyphoscoliosis (15 cases). The follow-up period ranged from 6 to 155 months. Clinical improvement was observed in all patients.

CONCLUSIONS
Understanding and treating CAAD may have significant implications in the surgical treatment of a number of clinical entities. The gratifying clinical outcomes obtained in patients after atlantoaxial fixation, without any type of decompression involving bone or soft-tissue resection, consolidate the concept that atlantoaxial instability has a defining role in the pathogenesis.
PROMOTING ICT IN EDUCATION: THEORETICAL AND PRACTICAL ROLES TO ENHANCE A BETTER LEARNING
Authors: Mudra Heri 
Published: March 2023

Teknologi informasi dan komunikasi memiliki manfaat dan kelemahan untuk siswa di kelas pengajaran bahasa Inggris. Peran teknologi informasi dan komunikasi tidak dapat lepas dari kelemahannya., karena setiap fungsinya tidak hanya dapat membantu, namun juga berbahaya untuk siswa jika mereka menggunakannya untuk hal-hal yang negatif. Untungnya penggunaan teknologi infomasi dan komunikas dalam kelas harus selalu dipromosikan guru Bahasa Inggrsis yang mengharapkan bahwa siswanya akan mendapatkan informasi lebih dan terbaru melalui peralatan seperti internet. Untuk meyakinkannya, guru akan menjadi model dalam menggunakannya. Mereka harus menyajikan cara belajar yang efektif dan modern dengan menggunakan peralatan yang canggih seperti internet, ponsel android,dan jenis lain dari peralatan wireless. Teori harus diikuti oleh praktek yang nyata yang dapat dengan mudah diraih oelh siswa. Lebih banyak praktek yang mereka lakukan, maka mereka akan menjadi lebih baik lagi. Faktanya telah banyak ahli menggunakan teknologi infomasi dan komunikasi dalam bidang pendidikan. Information and Communication Technology (ICT) has both advantages and disadvantages for learners in an ELT classroom. The roles of ICT are not separated from their weaknesses, since each function of ICT tools is not only helpful , but also harmful for learners if they are utilized in a wrong way. Fortunately, the use of ICT in the classroom should always be promoted by English teachers who expect that their learners will obtain more and up-to-date information via the tools such as the internet. To convince, the teachers are the models of using the tools. They have to present effective and modern ways of learning by using advanced tools such as the internet, android mobile phone, and other types of wireless tools. Theories have to be followed by a real practice that can be easily achieved by the learners. The more practice they practice, the better they will be. The fact has been testified by many experts in the use of ICTs in education.
Total Phenolic and Total Flavonoid Content, Antioxidant Activity, and Nutritional Profile of Ziziphus mauritiana Fruit Juice
Authors: Adilah Hanifa Nur , Saleh Muhammad Irsan , Az-Zahra Novia Deliasari Aliyya , Cho Eunjin , Sinaga Ernawati 
Published: March 2023

Ziziphus mauritiana is a plant species belonging to the Rhamnaceae family. It is commonly found in tropical and subtropical regions of Asia, and in Indonesia, this plant grows wild and thrives on the islands of Bali, Lombok and Sumbawa. The fruits of Z. mauritiana are edible, however, in Indonesia, it is underutilized and has very low economic value. To evaluate its possibility to be developed as a functional food, this study was conducted to determine the total phenolics and flavonoids, dietary fiber, and nutrients contained in the fruit juice of Ziziphus mauritiana. Total phenols and flavonoids contents were determined using Folin Ciocalteu and AlCl3 methods, respectively. The in vitro antioxidant activity of the juice was evaluated using the DPPH method. The content of soluble and insoluble dietary fiber was determined using the standard AOAC analysis method, and proximates analysis was conducted in accordance with SNI 01-2891-1992. The results of this study revealed that freeze-dried juice of Z. mauritiana fruit has total phenols content of 1690 mg GAE/100g, total flavonoids of 15.10 mg QE/100g, soluble dietary fiber of 0.61%, and insoluble dietary fiber 2.03%. However, the antioxidant activity of Ziziphus mauritiana fruit juice was weak with IC50 328.54 ppm. The proximate analysis revealed the crude fiber in the freeze-dried fruit juice was 0.56%, carbohydrates 82.43%, protein 3.34%, fats 0.31%, ash 3.62%, and water 10.30%. In conclusion, Ziziphus mauritiana fruit juice has a high content of total phenolic substances, high dietary fiber, and high nutritional value, therefore it has a good potential to be developed as a functional food.
Multi-objective Optimal Power Flow and Emission Index Based Firefly Algorithm
Authors: Mezhoud Nabil 
Published: March 2023

The economic operation of electric energy generating systems is one of predominant problems in energy systems. In this work one evolutionary optimization method, based on the meta-inference behavior called the Firefly Algorithm (FFA) is applied to solve such as the multipurpose optimum power flow (OPF) and emission index (EI) problems. Our main goal is to improve the objective function necessary to achieve the best balance between production and its energy consumption, which is presented as a non-linear function, taking into account some constraints of equality and inequality. The goal is to reduce the total cost of generations, active losses, and emission index.The FFA approach was examined and tested on a standard IEEE-30 bus system. The validations of obtained results were compared with some well-known and recently published references. The efficiency and credibility of the proposed method has been proven by the obtained results.
The advantages of humanistic science learning tools
Authors: Sudarto Sudarto 
Published: March 2023

This study aimed to determine the advantages of humanistic science learning tools. The collection data was cocducted by in-depth interviews and questionnaire. Data analysis techniques used namely: data reduction, data display, and conclusions drawing. The results of this study showed that the advantages of humanistic science learning tools were (1) making the teachers could teach Science easily, (2) providing high motivations to the teachers in teaching Science, (3) making the teachers more aware in developing the students' emotional, spiritual, and creativity potentials in Science learning, (4) Making the students felt happy to the Science learning, (5) Making the students more easier to understand the Science, (6) Motivating the students to learn Science, (7) Making the students more aware that the emotional, spiritual, and creativity potential had to be grown in science learning and (8) Opening students' horizons to develop their emotional, spiritual, and creative potential in their daily lives independently.
Assessment of Volume Status in Chronic Hemodialysis: Comparison of Lung Ultrasound to Clinical Practice and Bioimpedance
Authors: Vareesangthip Kornchanok , Thanapattaraborisuth Banthita , Chanchairujira Kullanuch , Wonglaksanapimon Suwimon , Chanchairujira Thawee 
Published: March 2023

Objective: To compare LUS with other volume assessment methods, and to verify the prognostic value of LUS in Thai chronic HD patients.
Materials and Methods: We conducted a prospective cohort study in 36 chronic HD patients. Volume status before the HD session was evaluated by physical examinations, bioimpedance analysis (BIA), and ultrasound lung comets (ULCs). Mortality and morbidities were recorded during a 1-year follow-up period.
Results: The degree of lung fluid accumulation was assessed by summation of the number of ULCs, and was classified into 3 groups: mild-to-moderate (ULC<15–29), severe (ULC=30–59), and very severe (ULC>60) in 11.1%, 77.8%, and 11.1% of the patients, respectively. Either clinical edema or lung crackle had low sensitivity (20-32%) to detect extravascular lung water excess in patient with mild-to-moderate ULC and severe ULC. Overhydration assessed by BIA was found in 75% and 64.3% of patients with mild-to-moderate and severe ULC, respecively. In patients with very severe ULC, the admission rate due to volume overload was significantly higher, there was also a trend of increased mortality, as well as intradialytic complications.
Conclusion: Clinical assessment and BIA have limited value in determining extravascular fluid excess in the lung. Lung ultrasound is a useful tool to detect subclinical pulmonary congestion. The long-term outcome by using LUS-guided fluid management needs larger population studies.
Potential effect of luteolin, epiafzelechin, and albigenin on rats under cadmium-induced inflammatory insult: In silico and in vivo approach
Authors: Shahzadi Andleeb , Tariq Nusrat , Sonmez Haktan , Waquar Sulayman , Zahid Ayesha , Javed Muhammad Ahsan , Ashraf Muhammad Yasin , Malik Arif , Ozturk Munir 
Published: March 2023

Introduction: Cadmium(Cd) an industrial poison present abundantly in the environment, causes human toxicity by an inflammatory process. Chronic exposure of cadmium can cause a number of molecular lesions that could be relevant to oncogenesis, through indirect or epigenetic mechanisms, potentially including abnormal activation of oncogenes and suppression of apoptosis by depletion of antioxidants. As induction of cyclooxygenase (COX)-2 is linked to inflammatory processes, use of luteolin, epiafzelechin, and albigenin alone or in different combinations may be used as anti-inflammatory therapeutic agents.Methods: We, herein, performed in silico experiments to check the binding affinity of phytochemicals and their therapeutic effect against COX-2 in cadmium administered rats. Wistar albino rats were given phytochemicals in different combinations to check their anti-inflammatory activities against cadmium intoxication. The level of alanine aminotransferases (ALT), 4-hydroxynonenal (4HNE), 8-hydroxy-2-deoxyguanosine (8-OHdG), tumor necrosis factor-alpha (TNF-α), isoprostanes (IsoP-2α), COX-2, and malondialdehyde (MDA) were estimated with their respective ELISA and spectrophotometric methods.Results: The generated results show that phytocompounds possessed good binding energy potential against COX-2, and common interactive behavior was observed in all docking studies. Moreover, the level of ALT, 4HNE, 8-OHdG, TNF-α, IsoP-2α, malondialdehyde, and COX-2 were significantly increased in rats with induced toxicity compared to the control group, whereas in combinational therapy of phytocompounds, the levels were significantly decreased in the group. Discussion: Taken together, luteolin, epiafzelechin, and albigenin can be used as anti-inflammatory therapeutic agents for future novel drug design, and thus it may have therapeutic importance against cadmium toxicity.
Optimization and standardization of mNGS-based procedures for the diagnosis of Mycoplasma periprosthetic joint infection: A novel diagnostic strategy for rare bacterial periprosthetic joint infection
Authors: Cai Yuanqing , Ding Haiqi , Chen Xiaoqing , Chen Yang , Huang Changyu , Zhang Chaofan , Huang Zida , Huang Ying , Li Wenbo , Zhang Wenming , Fang Xinyu 
Published: March 2023

IntroductionThe diagnosis of Mycoplasma periprosthetic joint infection (PJI) is rather difficult due to its rarity and difficult in isolation, there are not standardized diagnostic procedure for Mycoplasma PJI presently. This study aimed to reported a metagenomic next-generation sequencing (mNGS)-based diagnostic strategy for Mycoplasma PJI.MethodsIn the present study, we have reported the largest number of Mycoplasma PJI that were precisely diagnosed by mNGS and verified by optimized microbial culture methods and (or) 16S PCR polymerase chain reaction (PCR).ResultsThe positive rate of optimized microbial culture methods and 16S PCR in the detection of Mycoplasma PJI was 57.14% and 71.43%, respectively. The infections were well controlled by targeted treatment in all cases.ConclusionThe standardized and optimized procedure based on mNGS presented in this study is useful for the diagnosis of Mycoplasma PJI, which might also be provided as a novel diagnostic strategy for rare bacterial PJI.
Relationship between left atrial appendage peak flow velocity and nonvalvular atrial fibrillation recurrence after cryoablation
Authors: Wang Long , Zhang Yan , Zhou Wei , Chen Jingjing , Li Yongkang , Tang Qian , Chen Bingxiu , Zhang Huiling , Zellmer Lucas , Chen Jin , Chen Zhangrong , Li Wei , Liu Xingde , Zhou Haiyan 
Published: March 2023

BackgroundPrevious studies revealed the connection between left atrial appendage peak flow velocity (LAA-PEV) and postoperative persistent atrial fibrillation (AF) recurrence. Yet, this association is not necessarily generalizable to persistent AF patients undergoing initial cryoballoon ablation due to current gaps in the literature.MethodsWe prospectively studied 74 consecutive individuals with persistent atrial fibrillation undergoing a cryoballoon ablation for the first time between January 2018 and January 2020. Before ablation, LAA-PEV was documented by transesophageal echocardiography (TEE). Subsequently, demographic information and other clinical characteristics of these participants were collected. A 96-h continuous cardiac monitor was reviewed regularly for recurrence of atrial fibrillation. Cox proportional hazards regression was used to investigate LAA-PEV as well as other clinical characteristics as a predictor of AF recurrence.ResultsOur study found that AF recurrences had lower LAA-PEV than those without AF recurrence. A nonlinear relationship between the LAA-PEV and AF recurrence was observed in this study, which had an inflection point of 34.9. Subgroup analysis of female participants showed that LAA-PEV had a positive correlation with AF recurrence [β = 0.8, 95% CI (0.7, 0.9), p &lt; 0.05].ConclusionA low LAA-PEV is related to recurrence of atrial fibrillation and may predict AF recurrence after initial cryoballoon ablation for persistent atrial fibrillation. This finding may help improve treatment and care strategies for patients with persistent atrial fibrillation.
Enhanced external counterpulsation improves dysfunction of forearm muscle caused by radial artery occlusion
Authors: Wang Zhenyu , Yao Chun , Huang Lihan , Liang Jianwen , Zhang Xiaocong , Shi Jian , Wei Wenbin , Zhou Jing , Zhang Yahui , Wu Guifu 
Published: March 2023

ObjectiveThis study aimed to investigate the therapeutic effect of enhanced external counterpulsation (EECP) on radial artery occlusion (RAO) through the oscillatory shear (OS) and pulsatile shear (PS) models of human umbilical vein endothelial cells (HUVECs) and RAO dog models.MethodsWe used high-throughput sequencing data GSE92506 in GEO database to conduct time-series analysis of functional molecules on OS intervened HUVECs, and then compared the different molecules and their functions between PS and OS. Additionally, we studied the effect of EECP on the radial artery hemodynamics in Labrador dogs through multi-channel physiological monitor. Finally, we studied the therapeutic effect of EECP on RAO at the histological level through Hematoxylin–Eosin staining, Masson staining, ATPase staining and immunofluorescence in nine Labrador dogs.ResultsWith the extension of OS intervention, the cell cycle decreased, blood vessel endothelial cell proliferation and angiogenesis responses of HUVECs were down-regulated. By contrast, the inflammation and oxidative stress responses and the related pathways of anaerobic metabolism of HUVECs were up-regulated. Additionally, we found that compared with OS, PS can significantly up-regulate muscle synthesis, angiogenesis, and NO production related molecules. Meanwhile, PS can significantly down-regulate inflammation and oxidative stress related molecules. The invasive arterial pressure monitoring showed that 30Kpa EECP treatment could significantly increase the radial artery peak pressure (p = 0.030, 95%CI, 7.236–82.524). Masson staining showed that RAO significantly increased muscle interstitial fibrosis (p = 0.002, 95%CI, 0.748–2.128), and EECP treatment can reduce this change (p = 0.011, 95%CI, −1.676 to −0.296). ATPase staining showed that RAO significantly increased the area of type II muscle fibers (p = 0.004, 95%CI, 7.181–25.326), and EECP treatment could reduce this change (p = 0.001, 95%CI, −29.213 to −11.069). In addition, immunofluorescence showed that EECP increased angiogenesis in muscle tissue (p = 0.035, 95%CI, 0.024–0.528).ConclusionEECP improves interstitial fibrosis and hypoxia, and increases angiogenesis of muscle tissue around radial artery induced by RAO.
Three-dimensional coseismic displacements and slip distribution of the 2021 Mw 7.4 maduo earthquake: Synergy of SAR, InSAR and optical images
Authors: Hua Jun , Gong Wenyu , Shan Xinjian , Zhang Guohong , Song Xiaogang 
Published: March 2023

On 21 May 2021, an earthquake of moment magnitude (Mw) 7.4 occurred near Maduo county in Qinghai Province China. This is the first major earthquake that occurred in the interior of the Bayan Har block in the Tibetan Plateau over the past 70 decades. Focusing on this event, we conducted a study on three-dimensional (3D) coseismic displacement reconstruction and its tectonic implication. We acquired both Synthetic Aperture Radar (SAR) and optical imaging satellite imagery, including SAR images from Sentinel-1 and Advanced Land Observation Satellite-2 (ALOS-2) as well as the multi-spectrum images from the Sentinel-2 (S2) satellite. We applied the Interferometric SAR (InSAR) and pixel-offset tracking (POT) techniques to coseismic SAR data pairs and reconstructed two dimensional displacements. With the constructed displacement fields in multiple viewing directions, we resolved the 3D coseismic displacements (north-south, east-west, and up components) by integrating the regional strain model with variance components estimation (SM-VCE). We recommend using the standard deviation value at each grid cell, which can be calculated in the resampling, as the initial weight. Based on the resolved 3D coseismic displacements, we further estimated the dip angles for the two segments (F4 and F5) in the east of the rupture zone. The associated moment magnitude is about Mw7.4, which corresponds to the released energy of ∼ 1.74×1020 Nm.