bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on multiaxial notch fatigue life of additively manufactured 316L considering mean stress and multiaxial stress state
Authors: Wang Wenxuan , Gong Shuai , Wang Yingyu , Zhang Xiaofan 
Published: August 2023

Abstract
Fatigue tests were performed on Additively Manufactured (AM) 316L steel. Then, a new energy based multiaxial notch fatigue life model was proposed, in which a virtual strain energy that can reflect the multiaxial effect of stress and the mean stress was used as the damage parameter, and a notch coefficient was used to modify the notch root damage parameter. The notch coefficient was defined as the area ratio between the normalized strain energy curves of the notch and the smooth specimen. The proposed approach was validated by the experimental data of AM 316L steel, and was compared with the theory of critical distance (TCD), as well as the local strain energy density method (SED). The results indicate that nearly 80% of the predicted data fall within the factor of 3 scatter band for the proposed method. The accuracy of the proposed method is better than the other two methods, and can be used for different notch geometries and loading paths.
PLCD3 inhibits apoptosis and promotes proliferation, invasion and migration in gastric cancer
Authors: Yu Yantao , Baral Shantanu , Sun Qiannan , Ding Jianyue , Zhang Qi , Zhao Fanyu , Gao Shuyang , Yao Qing , Yu Haoyue , Liu Bin , Wang Daorong 
Published: August 2023

Abstract
Gastric cancer (GC) is a heterogeneous disease whose development is accompanied by alterations in a variety of pathogenic genes. The phospholipase C Delta 3 enzyme is a member of the phospholipase C family, which controls substance transport between cells in the body. However, its role in gastric cancerhasnot been discovered. The purpose of this study was to investigate the expression and mechanism of action of PLCD3 in connection to gastric cancer. By Western blot analysis and immunohistochemistry, PLCD3 mRNA and protein expression levels were measured, with high PLCD3 expression suggesting poor prognosis. In N87 and HGC-27 cells, the silencing of PLCD3 using small interfering RNA effectively induced apoptosis and inhibited tumor cell proliferation, invasion, and migration. Conversely, overexpression ofPLCD3 using overexpressed plasmids inhibited apoptosis in AGS and BGC-823 cells and promoted proliferation, migration, and invasion. In order to investigate the underlying mechanisms, we conducted further analysis of PLCD3, which indicates that this protein is closely related to the cell cycle and EMT. Additionally, we found that overexpression of PLCD3 inhibits apoptosis and promotes the development of GC cells through JAK2/STAT3 signaling. In conclusion, PLCD3 inhibits apoptosis and promotes proliferation, invasion, and migration, which indicated that PLCD3 might serve as a therapeutic target for gastric cancer.
Dietary clove (Syzygium aromaticum) powder enhanced broiler chicken growth performance, carcass characteristics, nutrient digestibility, gut histomorphometry and health-associated whilst decreasing pathogenic microbiota
Authors: Ogwuegbu Mercy Chisara , Uzochukwu Ifeanyi Emmanuel , Ukah Ebube Glory , Obey Confidence Obioma , Okpanachi Uchele , Mthiyane Doctor Mziwenkosi Nhlanhla 
Published: August 2023

Abstract
This study investigated effects of dietary clove powder on growth performance, carcass traits, nutrient digestibility, jejunal histomorphometry and ileal health-associated as well as pathogenic microbiota populations in broiler chickens. A total of 250 Chikun strain day-old broiler chicks were randomly assigned to 5 dietary groups with 5 replicates of 10 birds each for 8 weeks in a completely randomized design. The groups were fed diets containing clove bud powder at 0, 0.5, 1.0, 1.5 and 2 g/kg diet (coded as CLO0, CLO5, CLO10, CLO15, and CLO20). Results showed dietary clove supplementation linearly increased (P < 0.001) slaughter weight and body weight gain whilst it quadratically increased total feed intake (P < 0.001) in boilers. Also, whilst there was no effect of diet (P > 0.05) on dressed weight and wing weight, dietary clove powder quadratically increased weights of live chickens at slaughter (P < 0.001), breast meat (P < 0.001), back cut (P < 0.001), and shank (P < 0.01), as well as the drumstick/thigh ratio (P < 0.001). Further, it linearly increased apparent digestibility of DM (P < 0.001), CP (P < 0.001), and EE (P < 0.01) as it quadratically increased CF (P < 0.01). Furthermore, it quadratically increased jejunal villus length (P < 0.05) and thickness of epithelium (P < 0.001) whilst it linearly increased crypt depth (P < 0.01) and thickness of muscularis (P < 0.001). Moreover, it increased ileal Lactobacilli (P < 0.05) whilst decreasing Salmonella (P < 0.05) and E. coli (P < 0.05) bacterial species. In conclusion, dietary clove powder improved growth performance, carcass characteristics, nutrient digestibility, gut histomorphometry and Lactobacilli while it decreased Salmonella and E. coli bacteria. It can be included in broiler diets at 1.0 to 1.5 g per kg diet without adverse effects.
How do parents manage their children's fever? A cross-sectional study related to mothers' knowledge
Authors: Tariverdi Marjan , Bolouki Samieh Sakhtemanpour , Tamaddondar Mohammad , Rahmati Mohammad Bagher , Mohammadian Maryam , Satarzadeh Mohammad 
Published: August 2023

Abstract
Introduction
This study was designed and conducted to investigate the level of knowledge of mothers of febrile children regarding care and treatment measures at the time of referral to medical centers in patients referred to Bandar Abbas Children's Hospital.
Method
This cross-sectional study was conducted on 300 mothers of febrile children referred to Bandar Abbas Children's Hospital during a two-month period in 2022. The desired information on fever treatment and control was collected using a 15-item researcher-made questionnaire.
Results
Three hundred mothers of children with fever who had visited the hospital were included. A total of 113 people were illiterate and had less than a diploma, and 187 people had a diploma or higher. Fifty mothers did not know what temperature constitutes a fever, 78 considered a temperature of 37°C or higher as a fever, and 55 considered a temperature of 37.5°C as a fever. Most mothers (176 individuals) noticed fever through body warmth, while 77 noticed it through a thermometer. The first action of 207 mothers was footbath, while the first action of only 92 mothers was to visit a doctor. A total of 265 mothers preferred to use acetaminophen, and 35 preferred ibuprofens as a fever reducer. The majority of mothers who preferred acetaminophen gave it every 6 hours, with only 8.35% giving it every 4 hours.
Conclusion
Most mothers in this study did not have accurate knowledge of how to treat and care for a child with a fever, especially those with lower education levels. It is essential to implement educational programs to inform mothers about fever in children.
Radiation Dose During Transarterial Chemoembolization and Risk Factors for High Radiation Dose
Authors: Choi Tae Won , Chung Jin Wook 
Published: August 2023

Abstract
The present study aims to provide detailed reports on radiation doses during transarterial chemoembolization (TACE) in the cone-beam computed tomography (CBCT) era and identify the risk factors for high radiation doses. This retrospective study included 385 consecutive patients who underwent initial conventional TACE for hepatocellular carcinoma (HCC) between January 2016 and December 2017. In most cases, CBCT was performed at the common hepatic artery or celiac axis to confirm the location of the tumor and the three-dimensional hepatic artery anatomy. Information on total dose area product (DAP), total cumulative air kerma (CAK), fluoroscopy time, and DAP and CAK of each digital subtraction angiography (DSA) and CBCT scan was recorded. Multiple linear regression analysis was performed to identify the risk factors for high DAP during TACE. The mean values of total DAP and CAK were 165.2 ± 81.2 (Gy·cm²) and 837.1 ± 571.0 (mGy), respectively. The mean fluoroscopy time was 19.1 ± 10.3 min. The mean DAP caused by fluoroscopy, DSA, and CBCT was 51.8 ± 43.9, 28.0 ± 24.1, and 83.9 ± 42.1 Gy·cm², respectively. Male sex, a high body mass index, largest tumor size >3 cm, presence of aberrant right and left hepatic arteries, and a large number of selectively treated vessels were identified as independent predictors of high total DAP during TACE. In conclusion, we provided detailed reports on radiation doses during TACE and the risk factors for high radiation doses.
Joint Design Influence on Laser-MIG Hybrid Welding of Maraging Steel
Authors: L Subashini , Prabhakar KV Phani , Ghosh Swati 
Published: August 2023

Abstract
Laser-MIG Hybrid welding (LHW) was performed in a single- pass on M250 maraging steel plates of 10 mm thickness with three modified joint designs. A Y-groove joint preparation with included angles (IA) of 16°, 24°, and 30° and root face of 2.5 mm was used. Welding was performed using M250 W2 filler wire. The heat input for welding increased as the IA increased. The composition of weld fusion zone affected the reverted austenite (RA) volume fraction formed on aging. With an increase in base metal melting, the fusion zone was enriched with solute elements such as Ni, Mo and Ti, ultimately increasing RA after aging. When the transverse tensile strength of all welds was comparable to that of the parent metal, a significant reduction in KIc fracture toughness of fusion zone (FZ) was observed as the RA increased. The space between neighboring RA pools (formed in intercellular regions) was smaller in the laser fusion zone (LFZ) owing to its fine grain size compared to the arc fusion zone (AFZ), and the welds failed by connecting series of cavities that only arise in the RA. LFZ appears to play an important role in determining weld toughness of LHW welds.
Genetic Chronicle of the Capybara: The Complete Mitochondrial Genome of Hydrochoerus hydrochaeris
Authors: Pasa Rubens , Menegídio Fabiano Bezerra , Garcia Caroline , Silva Iuri Batista da , Kavalco Karine Frehner 
Published: August 2023

Abstract
A brazilian digital influencer has kept a capybara (named Filó) in captivity, using her in his videos, which is against the law in Brazil. Because of this, she was confiscated by professionals from the IBAMA (Institute for the Environment and Renewable Natural Resources). However, the commotion surrounding the confiscation of the animal disregards the dangers associated with humans being in close proximity to wild animals. Despite their widespread and sanitary importance, Hydrochoerus hydrochaeris lacks a description of its complete mitochondrial genome. To fill this gap, we assembled and annotated the mitogenome of capybara and used it to make the phylogeny of the related groups.
Evaluation of antioxidant enzyme levels, oxidative stress markers and serum prolidase activity in testicular cancer
Authors: Kılıç Sinan , Kaba Mehmet , Kaba Sultan 
Published: August 2023

Abstract

Background: Testicular cancer is a significant malignancy affecting males, and understanding the underlying biochemical changes associated with the disease is essential for improved management and treatment strategies. The enzyme prolidase, which plays a very important role in collagen metabolism, has been associated with various disease mechanisms, especially cancer.
Objective: Evaluation of the association of antioxidant enzyme levels, oxidative stress markers, and serum prolidase activity with testicular cancer may provide valuable information regarding the pathophysiology of the disease. In this study, it was aimed to investigate antioxidant enzyme levels, oxidative stress markers, and serum prolidase activity in adult and pediatric patients diagnosed with testicular cancer.
Methods: A total of 33 male patients (mean age: 25.3 ± 11.1 years, range: 1-52) diagnosed with testicular cancer were included, along with 35 age-matched male volunteers as the control group (mean age: 27.4 ± 8.2 years). Serum specimens were gathered and preserved at a temperature of -20°C until the time of analysis. The analysis involved superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GSHPx), and prolidase levels, shedding light on the intricate mechanisms of testicular cancer.
Results: The study revealed that patients with testicular cancer had notably higher levels of serum prolidase activity and malondialdehyde (MDA), compared to the control group (all with p-values < 0.05). On the other hand, levels of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), and glutathione-S-transferase (GST) were significantly lower in testicular cancer patients (all with p-values < 0.05).
Conclusion: Our research uncovers a potential link connecting heightened serum prolidase activity, oxidative stress, and the presence of testicular cancer. The findings suggest the involvement of oxidative stress in the pathogenesis of testicular cancer and emphasize the importance of prolidase as a potential biomarker for the disease.
Output-Feedback Based Event-Triggered Formation Control for USVs with Obstacle Avoidance Mechanism
Authors: Liu Shang , Zhang Guoqing , Guo Ge , Li Jiqiang 
Published: August 2023

Abstract
This paper focuses on the output-feedback based event-triggered control strategy for the formation tracking and obstacle avoidance activity of unmanned surface vehicles (USVs) with unmeasurable velocity, constrained communication and actuator fault. To be specific, an event-triggered based state observer is designed by using the neural networks (NNs) and minimal learning parameter (MLP) technique, which releases the constraint of continuous feedback signal acquisition and reduces the communication burden from sensor to controller channel. Using the designed observer, an adaptive triggering condition with adjustable threshold is derived, so that the triggered state and the adaptive law are updated only in the discrete-time domain. Furthermore, by virtue of the artificial potential field (APF) method, a novel obstacle avoidance mechanism is developed for USVs formation to achieve obstacle avoidance and waypoints-based path navigation performance. Based on above design, the output-feedback based event-triggered controller is derived and only two aperiodic adaptive laws are designed to compensate the actuator fault and system uncertainties. Considerable effort has been made to guarantee the semi-globally uniformly ultimately bounded (SGUUB) stability. Finally, two numerical simulations are illustrated to demonstrate the remarkable performance of the proposed control strategy.
Unveiling Rare Neurovascular Complexity; A Rare Bilateral Thalamic Infarction Case Report and Concise Literature Review
Authors: Achhami Eliz , Lamichhane Seshkanta , Kandel Ashim , Mahaju Satyam , Poudel Anubhav , Adhikari Lukash 
Published: August 2023

Abstract
Background: Bilateral thalamic infarction resulting from the occlusion of the artery of Percheron (AOP) is an exceedingly rare cerebrovascular event. The intricate interplay between neurovascular anatomy, midbrain function, and clinical manifestations in such cases remains an area of clinical interest and exploration.
Case Presentation: We present the case of a 48-year-old male farmer with a known history of Diabetes mellitus, who presented with diplopia, bilateral drooping of eyelids, and eventually loss of consciousness while working in the field. Initial management centered around suspected meningioencephalitis, given fever and unresponsiveness. Advanced evaluations, including brain MRI and MRA, led to the diagnosis of bilateral upper midbrain infarction involving the artery of Percheron. The patient's clinical course revealed an improvement in consciousness and responsiveness over three weeks of conservative management.
Conclusions: This case report highlights the clinical rarity and diagnostic challenges associated with bilateral thalamic infarction due to AOP occlusion. The complex neurovascular interplay revealed by this case emphasizes the importance of precise diagnosis and tailored management in rare cerebrovascular events. The insights gained from this case contribute to a deeper understanding of the clinical impact and potential implications of such occurrences within the realm of stroke and cerebrovascular diseases.
Effect of polystyrene microplastics on the antioxidant system and immune response in GIFT (Oreochromis niloticus)
Authors: Zheng Yao , Addotey Tracy Naa Adoley , Chen Jiazhang , Xu Gangchun 
Published: August 2023

Abstract
Recent investigations have reported large number of microplastics (MPs) in the freshwater environment, which may have adverse effects on growth and development of freshwater organisms. The present study was conducted to investigate the effects of chronic sub-lethal dose of MPs on the oxidative status (ROS, SOD) and immune response (IL-1ß, TNF-α) of the genetically improved farmed tilapia (GIFT). Juveniles of GIFT (5.1 ± 0.2 g) were exposed to concentrations of 0 (group A), 75 nm (group B), 7.5 µm (group C), 750 µm (group D), 75 nm + 7.5 µm + 750 µm (group E) and 75 nm + Chlorella (group F). ROS content in the brain and gills were significantly decreased in group F and significantly increased in group D after the 14 d exposure. SOD activities in the intestine showed an elevation in group F and in the brain and gills in group D, and that of the gills generally decreased over time in group B and F. The highest ROS and SOD levels were observed in the brain in group D with the lowest in the intestines at the same concentration. The activity of IL-1ß was significantly up-regulated in the liver across all the exposure groups. IL-1ß was significantly up- regulated in the brain of group B and in the gills of group D. TNF-α was significantly up- regulated in the brain of group B/D/E, in the liver of group B/C/D, in the intestine of group B and in the gills of group D. The highest IL-1ß and TNF-α activities were recorded in the brain and the lowest in the intestine in group D. Overall, the current study revealed that GIFT’s immune response and antioxidant system could be affected by MPs.
GAPiM: Discovering Genetic Variations on a Real Processing-in-Memory System
Authors: Abecassis Naomie , Gómez-Luna Juan , Mutlu Onur , Ginosar Ran , Moisson-Franckhauser Aphélie , Yavits Leonid 
Published: August 2023

Abstract

Variant calling is a fundamental stage in genome analysis that identifies mutations (variations) in a sequenced genome relative to a known reference genome. Pair-HMM is a key part of the variant calling algorithm and its most compute-intensive part. In recent years, Processing-in-Memory (PiM) solutions, which consist of placing compute capabilities near/inside memory, have been proposed to speed up the genome analysis pipeline. We implement the Pair-HMM algorithm on a commercial PiM platform developed by UPMEM. We modify the Pair-HMM algorithm to make it more suitable for PiM execution with acceptable loss of accuracy. We evaluate our implementation on single chromosomes and whole genome sequencing datasets, demonstrating up to 2x speedup compared to existing CPU accelerations and up to 3x speedup compared to FPGA accelerations.
Study of radiation dose due to 226Ra, 222Rn and 210Po in drinking water of Chamarajanagar district, Karnataka, India
Authors: K. Lavanya B. S. , N. Namitha S. , Hidayath Mohamed , S. Pruthvi Rani K. , M. Saveena J. , S. Chandrashekara M. 
Published: August 2023

Abstract
Groundwater dissolves radioactive minerals like uranium, radium, radon and polonium during its flow. 226Ra, 222Rn, and 210Po are the decay products of the 238U series which causes ingestion dose to human being. The activity of these radionuclides was studied in groundwater samples collected from Chamarajanagar district, Karnataka, India. 226Ra, 222Rn and 210Po concentration in bore well water samples were varied from 2.18 to 96.42mBql− 1, 0.94 to 26.95Bql− 1, 0.72 to 6.33mBql− 1 respectively. The average ingestion dose due to 226Ra, 222Rn and 210Po were 6.41, 11.60 and 2.51µSvy− 1 respectively.
A Novel Surgical Landmark to Identify the Recurrent Laryngeal Nerve (Identifying Recurrent Laryngeal Nerve)
Authors: Dundar Yusuf , Schwartz Cynthia M , Lierly Micah , Nguyen Tam Q , Gilbert Kerry K. , Smith Drew , Tello Nadia , Cordero Joehassin 
Published: August 2023

Abstract

Objective
There are many surgical landmarks have been proposed to localize the recurrent laryngeal nerve (RLN). However, there is still no reliable landmark to find the RLN precisely. The objective was to use the inferior border of the cricopharyngeal muscle and the ICTC to define a reliable landmark for the RLN.
Methods
Cadaver dissection study in an Academic Otolaryngology-Head and Neck Surgery Residency Training Program. A cadaveric study of 64 RLNs was carried out, including measurements of different surgical landmarks in conjunct to proposed surgical landmark (Dundar’s point).
Results
The average distance from the reference point to the RLN is 2.3mm and the RLN is localized just posterior to the reference point in 95.3% of dissection specimens. The RLN passes under the inferior constrictor muscle in 90.6% of the cases. There was no statistically significant difference between right and left RLNs in term of relation with the reference point.
Conclusions
The proposed surgical point can be used as a reliable landmark to identify the RLN. This reference point can help surgeons during difficult cases by providing additional anatomical landmark.
Level of Evidence: IV
Preserving Flow Table Integrity in OpenFlow Networks through Smart Contract
Authors: Bargayary Birglang , Medhi Nabajyoti 
Published: August 2023

Abstract
SDN revolutionises network management by providing a centralised controller that enables flexible and effortless configuration of networks. However, this flexibility also leads to a vulnerability that enables the adversary to trick the security system into allowing the installation of unauthorised flow rules in the switches. Blockchain provides us with a way to protect against malicious tampering with flow rules by storing them in the distributed ledger. In this work, we propose FTISCON, a mechanism to preserve the integrity of the OpenFlow flow table that utilizes blockchain technology. We employ the Ethereum Private Blockchain to implement the proof-of-concept and conduct a comparative analysis of the proposed scheme and existing related schemes, evaluating their performance in terms of delay, computation time, transaction cost, and detection rate. The proposed work is found to perform better in each of these. The study results suggest that the proposed approach offers a practical and efficient remedy to prevent flow modification attacks within SDN networks.