bluuebunny/crossref_metadata_2025_split huggingface dataset:
The molecular mechanism of Xiaoxuming decoction in the treatment of ischemic stroke based on network pharmacology and molecular docking
Authors: Li Xiang , Wang Peng , Zheng Kaixuan , Qi Shiqian , Tang Dan 
Published: September 2023

AbstractXiaoxuming decoction is a traditional Chinese medicine that has been widely used in the clinical treatment of ischemic stroke (IS). This study employed network pharmacology to identify the bioactive molecules and therapeutic mechanism of Xiaoxuming decoction against IS. First, the traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) was utilized to obtain the ingredients and potential target proteins related to IS in the Xiaoxuming decoction. Subsequently, known target proteins related to IS were collected from online Mendelian inheritance in man (OMIM), Disgenet, and Gencards databases. The mechanism of Xiaoxuming decoction against IS was identified by enrichment analysis of gene ontology (GO) and Kyoto Encyclopedia of genes and genomes (KEGG). Additionally, protein–protein interaction data were obtained from the search tool for the retrieval of interacting genes/proteins (STRING). The hub gene was further screened out from the gene expression omnibus (GEO) and verified by molecular docking. The study identified a total of 183 candidate molecules and 140 targets related to IS. These candidate targets regulate biological processes including inflammation, autophagy, oxidative stress, and vascular reaction. Our findings provide a comprehensive demonstration of the active compounds, key targets, main signaling pathways, and underlying molecular mechanisms of Xiaoxuming decoction in treating IS.
On the application of high‐throughput experimentation and data‐driven approaches in metallic glasses
Authors: Xie Weijie , Wang Weihua , Liu Yanhui 
Published: September 2023

AbstractMaterials genome engineering (MGE) has been successfully applied in various fields, resulting in a series of novel materials with excellent performance. Significant progress has been made in high‐throughput simulation, experimentation, and data‐driven techniques, enabling the effective prediction, rapid synthesis, and characterization of many classes of materials. In this brief review, we introduce the achievements made in the field of metallic glasses (MGs) using MGE, in particular high‐throughput experimentation and data‐driven approaches. High‐throughput experiments help to efficiently synthesize and characterize many materials in a short period of time, enabling the construction of high‐quality material databases for data‐driven methods. Paired with machine learning, potential alloys of desired properties may be revealed and predicted. Along with the progress in computational power and algorithms of machine learning, the complex composition‐structure‐properties relationship is hopefully established, which in turn help efficient and precise prediction of new MGs.
A complex solution on the dynamic response of sandwich graphene‐reinforced aluminum‐based composite beams with copper face sheets under two moving constant loads on an elastic foundation
Authors: Eghbali Mohammadreza , Hosseini Seyed Amirhosein 
Published: September 2023

AbstractAn analytical solution was used to investigate the elastic response of a sandwich beam with a graphene‐reinforced aluminum‐based composite (GRAC) on an elastic foundation using copper as the face layer of the functionally graded composite beam and a simply supported boundary condition. Mantari's higher‐order shear deformation theory was utilized to derive the equations, which were solved in Laplace space and then converted into space–time using Laplace inversion. The exact response of the GRAC sandwich beam was obtained by considering the displacement at the mid‐span of the sandwich beam. Two moving loads with different speed ratios were applied at a single point, and the effect of various parameters, including the spring constant, the speed ratio, the percentage of graphene, the moving load speed, and the distribution pattern, was investigated. This study aimed to eliminate any overlap and improve the accuracy of the results. The exact solving method presented has not been reported in other articles so far. Additionally, due to the difficulty of solving mathematical equations, this method is only applicable to simple boundary conditions.
Spectacular Innovations and Global Outreach
Authors: Bhowmik Achin 
Published: September 2023

AbstractThis issue of Information Display continues to highlight key technologies and industry trends in the in‐depth reports from Display Week 2023. At the 60th annual international symposium and exhibition organized by the Society for Information Display (SID), Display Week once again lived up to its longstanding status as the premier global forum to experience the future of displays, imaging, and related technologies.
A pilot investigation of muscle integrity in patients with ADSSL1 myopathy using electrical impedance myography
Authors: Farid Alexander Rashad , Golden Emma , Hu Alice , Robicheau Sara , Rutkove Seward , Al‐Hertani Walla , Upadhyay Jaymin 
Published: September 2023

AbstractIntroduction/AimsADSSL1 myopathy (OMIM 617030) is a recently discovered, congenital myopathic disease caused by a pathogenic variant in ADSSL1. ADSSL1 is an enzyme involved in the purine nucleotide process and facilitates the conversion of inosine monophosphate to adenosine monophosphate within myocytes. Electrical impedance myography (EIM) is a portable, non‐invasive, and cost‐effective method for characterizing muscle integrity. Three ADSSL1 patients are presented in whom characterization of muscle integrity using EIM was performed.MethodsA 15‐y‐old male, 20‐y‐old female, and 63‐y‐old male each with a pathogenic variant in ADSSL1 [c.901G > A] as well as three, age‐gender matched healthy controls (HCs) were enrolled. Study participants were phenotyped using a virtual EIM procedure.ResultsADSSL1 myopathy patients presented with variable onset of physical disability, disease progression, and severity of muscle weakness. Across multiple proximal and distal muscles groups and relative to HCs, ADSSL1 myopathy patients demonstrated lower phase and reactance values, while resistance was higher, which together indicated diseased muscle.DiscussionEIM can provide a novel, non‐invasive and objective biomarker to evaluate muscle integrity in patients with ADSSL1 myopathy. Combining EIM with musculoskeletal imaging and histologic assessments in follow‐up studies may further inform on the pathophysiology of ADSSL1 myopathy.
Establishing an evaluation index system of nursing quality for clinical drug trials: A Delphi study
Authors: Chen Junyi , Zhou Huiyu , Mai Qingxiu , Chen Shuping , Liu Qingyin , Shi Mengyun , Lin Yunni , Yan Lihong , Li Meiyu , Ye Suiwen , Yao Herui 
Published: September 2023

AbstractAimsTo construct a quality evaluation index system for clinical drug trials nursing management and obtain the weight of all indicators.DesignA mixed‐method research design with a quantitative component was used, primarily qualitative.MethodsThrough a literature review and semi‐structured interview, an expert consultation questionnaire on the quality of nursing evaluation indicators for clinical drug trials was developed in April 2021. Eighteen experts in clinical drug trial nursing, medical, and pharmacy conducted 2 rounds of consultation according to the Delphi method to determine the indicators for evaluating the quality of clinical drug trial nursing. The weights of each indicator were determined using analytic hierarchical analysis.ResultsThe established quality evaluation system of clinical drug trial nursing mainly includes 3 first‐level indicators, 12 second‐level indicators, and 59 third‐level indicators. The positive coefficients of the two rounds of expert consultation were 90%–100%, and the authority coefficients were 0.831 and 0.885, respectively; the coordination coefficients were 0.189 and 0.214, respectively. The consulting results and weight settings are reliable. The evaluation index system we constructed is in line with the characteristics of the clinical drug trial nursing profession, with clear index levels and strong clinical operability, which can provide a reference for the assessment, monitoring and improvement of nursing quality in clinical drug trials. It will also clarify how nurses contribute to subjects' safety.
Cooperation after social exclusion: To reconnect or to harm?
Authors: Đorić Stefan 
Published: September 2023

AbstractPredicting a person's reaction after experiencing exclusion is an important question, which is accompanied by paradoxical answers. An excluded person may tend to harm others (antisocial reaction hypothesis), treat them with increased ingratiation (prosocial reaction hypothesis), or withdraw from further social contacts. The aim of this study was to test the hypotheses about the prosocial and antisocial responses in the social dilemma context, specifically, to examine whether social exclusion will result in reduced or increased cooperation in the Trust Game. The sample included 175 participants (females = 142), first‐ and second‐year psychology students. There was a between‐subject design 3 exclusion (exclusion vs. inclusion vs. neutral) × 2 history (known vs. unknown partner), with Social value orientation being treated as a covariate. Social exclusion was manipulated using the get‐acquainted paradigm, and the Trust Game was used to measure the willingness to cooperate. The level of social value orientation was measured using the Social Value Orientations (SVO) Slider Measure. Despite the successful manipulation of social exclusion, the results do not support studies showing that exclusion influences cooperation in a mixed‐motive situation. Only the main effects of the history were observed (p = .012, η2 = .04.), and social value orientation was a significant predictor of the level of cooperation (p ≤ .001, η2 = .08.). The conclusion is that the experience of social exclusion made participants no less able to analyze social cues and willing to cooperate in the Trust Game.
Perceptual contrast reduces the judgments of learning of small‐font words and increases the judgments of learning of large‐font words compared with the no‐contrast conditions
Authors: Wan Bowen , Zha Jinlian , Zheng Xiaoqian , Li Haifeng 
Published: September 2023

AbstractThe font‐size effect on judgments of learning (JOLs) refers to large‐font words being rated as more memorable than small ones when required to predict memory performance during the study phase. This study examines perceptual contrast as the prerequisite for this font‐size effect on JOLs and explores how perceptual contrast leads to this effect. In Experiment 1, perceptual contrast was achieved by inserting words with one font (e.g., 18 pt) into a series of words with another font (e.g., 70 pt) at a particular proportion (1:4). In Experiment 2, perceptual contrast was manipulated by presenting two different font words up and down in a pair. The results of both experiments showed that: (1) participants rated higher JOLs for large than small fonts under the contrast conditions, but the JOL difference between the two fonts was not significant under the no‐contrast conditions; (2) the JOLs of small‐font words under the contrast conditions was reduced compared with the no‐contrast conditions, but the JOLs of large‐font words under the contrast conditions was increased compared with the no‐contrast conditions. These results indicated that perceptual contrast was the prerequisite for the font‐size effect on JOLs. The reason for this effect is that, compared to no‐contrast conditions, perceptual contrast reduces the JOLs of small‐font words while increasing the JOLs of large‐font words. This study may deepen researchers' understanding of the mechanism of the font‐size effect on JOLs and help educators effectively guide students to learn.
Effects of root inoculation of entomopathogenic fungi on olfactory‐mediated behavior and life‐history traits of the parasitoid Aphidius ervi (Haliday) (Hymenoptera: Braconidae)
Authors: Wilberts Liesbet , Vuts József , Caulfield John C. , Thomas Gareth , Withall David M. , Wäckers Felix , Birkett Michael A. , Jacquemyn Hans , Lievens Bart 
Published: September 2023

AbstractBACKGROUNDAlthough most biological control programs use multiple biological agents to manage pest species, to date only a few programs have combined the use of agents from different guilds. Using sweet pepper (Capsicum annuum L.), the entomopathogenic fungus Akanthomyces muscarius ARSEF 5128, the tobacco peach aphid Myzus persicae var. nicotianae and the aphid parasitoid Aphidius ervi as the experimental model, we explored whether root inoculation with an entomopathogenic fungus is compatible with parasitoid wasps for enhanced biocontrol of aphids.RESULTSIn dual‐choice behavior experiments, A. ervi was significantly attracted to the odor of M. persicae‐infested C. annuum plants that had been inoculated with A. muscarius, compared to noninoculated infested plants. There was no significant difference in attraction to the odor of uninfested plants. Myzus persicae‐infested plants inoculated with A. muscarius emitted significantly higher amounts of indole, (E)‐nerolidol, (3E,7E)‐4,8,12‐trimethyltrideca‐1,3,7,11‐tetraene and one unidentified terpene compared to noninoculated infested plants. Coupled gas chromatography‐electroantennography, using the antennae of A. ervi, confirmed the physiological activity of these elevated compounds. Inoculation of plants with A. muscarius did not affect parasitism rate nor parasitoid longevity, but significantly increased the speed of mummy formation in parasitized aphids on fungus‐inoculated plants.CONCLUSIONOur data suggest that root inoculation of C. annuum with A. muscarius ARSEF 5128 alters the olfactory‐mediated behavior of parasitoids, but has little effect on parasitism efficiency or life‐history parameters. However, increased attraction of parasitoids towards M. persicae‐infested plants when inoculated by entomopathogenic fungi can accelerate host localization and hence improve biocontrol efficacy. © 2023 Society of Chemical Industry.
Electronic properties, quantum capacitance and photocatalyst for water splitting of Sc2CO2 MXene under uniaxial strain
Authors: Li Lu , Li Jin‐Hua , Hou Lei‐Lei , Li Xiao‐Hong , Zhang Rui‐Zhou , Cui Hong‐Ling 
Published: September 2023

AbstractMXenes have wide applications because of the structural flexibility and compositional diversity. Quantum capacitance, electronic and photocatalytic properties of Sc2CO2 monolayer under uniaxial strains are investigated by first‐principles calculation. Sc2CO2 monolayer can withstand stress up to 13.96 N/M and about 14% tensile uniaxial strain limit. Sc2CO2 undergoes a transition from semiconductor to metal at −15% uniaxial strain. Sc2CO2 under uniaxial strains are only used for the water reduction at pH = 0. Sc2CO2 under uniaxial strains of −10%, −7%, −3%, 0%, and 4% within the appropriate pH scope are potential photocatalysts for water redox reaction. Sc2CO2 with −15% uniaxial strain is promising anode material, and Sc2CO2 with tensile uniaxial strain is more potential cathode material. Wide voltage improves the top quantum capacitance at negative bias under uniaxial strain and keeps the type of electrode materials. Quantum capacitance of Sc2C with mixed termination (Sc2CO0.59F1.19(OH)0.22) under uniaxial strain is explored. The introduction of uniaxial strain and mixed termination has little effect on the electrode type of Sc2CO2 MXene.
Fat emboli—Related diffuse alveolar haemorrhage (FEDAH) an acronym to remember—Case series
Authors: Williams Benjamin Earnest , Nair Avinash A. , James Prince , Isaac Barney , Gupta Richa , Ashok Anand 
Published: September 2023

AbstractFat embolism syndrome (FES) is a rare but potentially fatal complication of trauma or orthopaedic surgery, which presents predominantly with pulmonary symptoms. The rapid worsening respiratory failure in a previously normal orthopaedic surgery or trauma patients usually get evaluated for pulmonary embolism, fat‐embolism‐related acute respiratory distress or transfusion related acute lung injury. Orthopaedic surgeons and clinicians need to be aware of related entity termed ‘Fat Embolism related Diffuse Alveolar Haemorrhage’ (FEDAH). The clinical presentation in an orthopaedic surgery of trauma patient with FEDAH are haemoptysis, worsening type 1 respiratory failure and oxygen requirement, drop in haemoglobin levels with chest x‐ray/computed tomography suggestive of Diffuse alveolar haemorrhage (DAH). Early bronchoscopy and bronchoalveolar lavage (BAL) confirmation of DAH, presence of BAL haemosiderophages and lipid‐laden macrophages are the pointers in the early diagnosis of FEDAH. It needs a high clinical suspicion and interdepartmental collaborative measures. Timely referral from orthopaedic surgeons, early bronchoscopy and treatment with steroids is key in diagnosis and management.
Analysis of trans‐domain motion process of bullet‐shaped trans‐domain amphibious vehicle
Authors: Gao Yong , Zhang Hao , Li Guigeng , Zhou Manli , Yin Hao , Gulliver T. Aaron 
Published: September 2023

AbstractA fully functional prototype of a bullet‐shaped trans‐domain amphibious vehicle with the ability to perform reciprocating cross‐medium movements has been developed. Once the bullet‐shaped underwater vehicle completes its designated underwater tasks, upon reaching a suitable location for surface observation, it will transform into a bullet‐shaped coaxial counter‐propeller aircraft to carry out cross‐domain out‐of‐water and performing aerial flight missions. The successful transition of the vehicle into amphibious mode is attributed to the design of an innovative energy attitude multiplexing mechanism. Simultaneously, a rational and effective hybrid‐switching strategy has been proposed to enhance the reliability of the vehicle's amphibious mode transition. In view of the complex and changeable cross‐domain environment, we have adopted a modular design concept, breaking down the entire cross‐domain movement process into three key phases: air operation flight, transient cross‐domain, and underwater active sailing. Detailed theoretical analysis, algorithm design, and experimental research have been conducted for each phase. This paper proposes and expounds the key design principles, evaluates the performance indicators of key components, and weighs the matching of body dynamics and propulsion performance to ensure that the vehicle achieves the expected performance. Finally, the success of the test at different phases further proves that the vehicle has the ability to achieve complete cross‐domain operation.
Near‐Infrared Photothermal Manipulates Cellular Excitability and Animal Behavior in Caenorhabditis elegans
Authors: Zhuang Siyi , He Mubin , Feng Jiaqi , Peng Shiyi , Jiang Haochen , Li Yunhao , Hua Ning , Zheng Yujie , Ye Qizhen , Hu Miaojin , Nie Ying , Yu Peilin , Yue Xiaomin , Qian Jun , Yang Wei 
Published: September 2023

AbstractNear‐infrared (NIR) photothermal manipulation has emerged as a promising and noninvasive technology for neuroscience research and disease therapy for its deep tissue penetration. NIR stimulated techniques have been used to modulate neural activity. However, due to the lack of suitable in vivo control systems, most studies are limited to the cellular level. Here, a NIR photothermal technique is developed to modulate cellular excitability and animal behaviors in Caenorhabditis elegans in vivo via the thermosensitive transient receptor potential vanilloid 1 (TRPV1) channel with an FDA‐approved photothermal agent indocyanine green (ICG). Upon NIR stimuli, exogenous expression of TRPV1 in AFD sensory neurons causes Ca2+ influx, leading to increased neural excitability and reversal behaviors, in the presence of ICG. The GABAergic D‐class motor neurons can also be activated by NIR irradiation, resulting in slower thrashing behaviors. Moreover, the photothermal manipulation is successfully applied in different types of muscle cells (striated muscles and nonstriated muscles), enhancing muscular excitability, causing muscle contractions and behavior changes in vivo. Altogether, this study demonstrates a noninvasive method to precisely regulate the excitability of different types of cells and related behaviors in vivo by NIR photothermal manipulation, which may be applied in mammals and clinical therapy.
Experimental study of the wake interaction between two vertical axis wind turbines
Authors: Huang Ming , Vijaykumar Patil Yugandhar , Sciacchitano Andrea , Ferreira Carlos 
Published: September 2023

AbstractWakes and wake interactions in wind turbine arrays diminish energy output and raise the risk of structural fatigue; hence, comprehending the features of rotor–wake interactions is of practical relevance. Previous studies suggest that vertical axis wind turbines (VAWTs) can facilitate a quicker wake recovery. This study experimentally investigates the rotor–wake and wake–wake interaction of VAWTs; different pitch angles of the blades of the upwind VAWT are considered to assess the interactions for different wake deflections. With stereoscopic particle image velocimetry, the wake interactions of two VAWTs are analysed in nine distinct wake deflection and rotor location configurations. The time‐average velocity fields at several planes upwind and downwind from the rotors are measured. Additionally, time‐average loads on the VAWTs are measured via force balances. The results validate the rapid wake recovery and the efficacy of wake deflection, which increases the available power in the second rotor.
The Matsudai Knee Osteoarthritis Survey showed the longitudinal changes of knee phenotypes in alignment and structure during 23–28 years
Authors: Tomiyama Yasuyuki , Mochizuki Tomoharu , Koga Hiroshi , Omori Go , Koga Yoshio , Tanifuji Osamu , Nishino Katsutoshi , Endo Kazuo , Endo Naoto , Kawashima Hiroyuki 
Published: September 2023

AbstractPurposeThe longitudinal changes in alignment and structure, including the joint line and cortical bone thickness (CBT) of the femur and tibia, and knee phenotype in patients with knee osteoarthritis (OA) remain unknown. The aim of this retrospective study was to clarify the longitudinal changes in matched healthy subjects.MethodsThe follow‐up Matsudai Knee Osteoarthritis Survey was administered between 23 and 28 years. This study included 285 healthy knees from 235 females with an average age of 53 ± 6 years at baseline. The non‐OA individuals, with an average age of 79 ± 4 years, were divided into three groups at baseline according to their follow‐up radiographic results [the non‐OA (n = 52), early OA (n = 131), and advanced OA groups (n = 102)]. Changes in alignment, joint line, CBT, and knee phenotype were assessed at baseline and at follow‐up using standing anteroposterior radiographs.ResultsThis study showed significant varus changes in the alignment (p < 0.001) and tibial and femoral joint line parameters (p < 0.05) in the OA group. Decreased CBT and increased mediolateral CBT ratios were observed in all groups (p < 0.001). The knee phenotypes in the OA groups were changed to varus angles, especially in the alignment and tibial joint line.ConclusionsThe longitudinal changes of knee phenotypes in alignment and structure (CBT and joint line) from baseline to follow‐up were shown in the OA groups. In addition, alignment and tibial structural factors at baseline are useful in predicting the incidence of knee OA in daily practice.Levels of evidenceIII.