bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Health Related Quality of Life in first-time denture wearers Using Balanced, Monoplane and Group function Occlusion
Authors: PARAKH Mayank Kumar , D Krishna Prasad , DEMERİE Farah 
Published: December 2022

Background: Oral Health Impact profile is one of the most common methods to assess the Oral Health Related Quality of Life (OHRQoL) of the patients.
Methods: In this study, a total of 66 edentulous participants were included and divided into 3 groups of 22 each using simple random sampling. OHIP-14 scores were assessed before complete denture treatment and at 6 months follow-up.
Results: When comparison of mean OHIP – 14 among the study population across gender before and after denture insertion was done the results were statistically significant. (P-value- 0.001) The difference between the follow-up scores and the scores before a denture when subjected to statistical analysis was significant for all three groups. When one-way ANOVA was done between the groups the data was statistically significant. (P-value
Is sclerostin antibody an effective agent for alveolar bone regeneration in animal models? A scoping review
Authors: BANU Sunaina , PUZHANKARA Lakshmi , KEDLAYA Madhurya N , VARGHESE Jothi M , RAMANARAYANAN Venkitachalam 
Published: December 2022

Objectives
The use of Sclerostin Antibody(Scl-Ab) as a bone anabolic agent has shown significant benefit in bone disorders in preclinical animal models and human clinical trials. Currently available evidence on the use of Scl-Ab in alveolar bone regeneration is limited to animal studies and hence this scoping review encompasses the animal studies conducted to ascertain the effectiveness of Scl-Ab on alveolar bone regeneration.
Materials and methods
The search strategy was aimed to locate published animal studies in which the treatment arm includes Sclerostin antibody administration for alveolar bone preservation or regeneration. The search terms used were (((Animal model) OR Rodent) AND Alveolar bone defect) AND Anti sclerostin antibody) OR Sclerostin antibody) AND Alveolar bone regeneration) OR Bone regeneration) AND Bone fill.
Results
Of the 559 results from Medline/PubMed, Scopus, Web of Science, Google scholar and additional articles from the references, six were included in the review. Scl-Ab was found to be effective in improving the bone quality and quantity. It was also observed that Scl-Ab was useful in reduced bone density associated with diseases and conditiona affecting osteoblast activity.
Conclusion
The review concluded that Scl-Ab promotes alveolar bone augmentation and improves bone quality without surgical interventions.
A CASE REPORT OF BEHÇET'S DISEASE WITH CORONARY ARTERY INVOLVEMENT
Authors: SAHİN Ali , ÇABUK ÇELİK Neşe , YALÇIN İlker , KARAKAŞ Burak , KARATAŞ Beliz 
Published: December 2022

ABSTRACT
We present a case of coronary artery thrombosis due to Behçet's disease. A 49-year-old female patient, diagnosed with Behçet's disease and followed up by us, applied to the emergency department with sudden onset of pressure-type chest pain, and was evaluated as acute myocardial infarction due to elevated cardiac enzymes and ST segment elevation in the anterior leads on electrocardiography (ECG). Coronary angiography revealed near-total thrombosis in the lumen of the left anterior descending artery (LAD) and in the circumflex (CX) artery,it was intervened with anticoagulant therapy. The patient's cardiac risk was found to be low and differential diagnosis was made in terms of myocardial infarction. Thereupon, the causes of hypercoagulability were investigated in the patient who was consulted to us, and acute phase reactants were found to be high. This was related to the coronary artery involvement of Behçet's disease and in addition to the treatment containing antiaggregant, statin, angiotensin receptor blocker, intravenous (IV) high-dose methylprednisolone and cyclophosphamide-mesna treatment was given for immunosuppressive purposes. It should not be forgotten that there may be vascular involvement due to Behçet's disease and coronary arteries may also be affected.
Visions et représentations du quartier de Chinatown à Paris dans les films français de l’extrême contemporain?: de l’exotisme au multiculturalisme
Authors: Pan Yue 
Published: December 2022

Cette étude examine les représentations du triangle de Choisy, le quartier reconnu comme Chinatown de Paris, dans trois films français contemporains : Augustin, roi du Kung-fu (1999), Paris, je t’aime (2006) et Made in China (2019). L’article a pour objectif de montrer le regard, qui se manifeste à travers ces films, porté par le courant dominant de la société française sur cette enclave urbaine et sur la sous-culture sino-française. Avec une analyse des images de paysage urbain du quartier, des personnages masculins occidentaux qui se présentent dans Chinatown et des personnages féminins d’origine asiatique qui habitent ici, l’article présente les représentations cinématographiques de ce Chinatown parisien à travers trois plans : sa postmodernité architecturale, sa fonction dans l’organisation sociale de Paris et son rapport avec le courant dominant de la société française. L’article fait valoir que le Chinatown parisien représente le côté multiculturel de Paris sur l’écran. Ainsi, les images de Chinatown nous permettent d’observer l’évolution du multiculturalisme dans la société française.
Copper Oxide Nanoparticles Induced Liver and Kidney Toxicity in Rat
Authors: El-Atrash Afaf , Zaki Somia , Tousson Ehab , Negm Marwa 
Published: December 2022

Aims: Copper oxide nanoparticles (CuO NPs), which have potential hazards for organisms and the environment in a number of applications, have emerged as a prominent class of nanomaterials.
Study Design: This study aimed to investigate the effect of copper oxide nanoparticles in rat liver and kidney tissues.
Methodology: A total of 20 adult male rats were assigned randomly to 2 groups [1st, control; 2nd, CuO NPs (400 mg/kg body weight/day) intraperitoneally for 4 weeks].
Results: Current results revealed significant increases in serum ALT, AST, urea, creatinine, potassium ions and liver and kidney tissue damage after CuO NPs administration when compared to control group. Conversely, statistical significant decreases were detected in serum albumin, total proteins, calcium and sodium ions levels in CuO NPs group as compared to control group.
Conclusion: We can conclude that; CuO NPs induced toxicity and injury in rat liver and kidney tissues.
Environmental Gradient: An Ecological Surrogate to Phytosociological Diversity of a Tropical Mangal-Rainforest-Ecotone in a Hydromesic Tripartite Plant Community
Authors: Lucky Edwin-Wosu, Nsirim , Tosanyemi Mojuetan, 
Published: December 2022

Aim: To assess influence of edaphic environmental gradients as surrogate to phytosociological diversity in a hyromesic habitat.
Study Design: A systematic sampling approach of line-transect method was used.
Place and Duration of Study: Field sampling: tropical mangal-rainforest ecotone in parts of Asarama, Andoni, Niger-Delta, Labortory analysis: Jack Petroanalytical Laboratory, and University of Port Harcourt Ecology Laboratory, Port Harcourt, Nigeria, between September 2020 and August 2021.
Methodology: Soil sampling and analyses was based on ASTM, Stewarte and conventional methods and the data obtained was subjected to statistical analysis.
Results: Recorded 90 plant species across the sampled sites with a prevalence of 6 (65.9%) species in mangrove, 64 (70.33%) in ecotone and 55(60.44%) in rainforest sites respectively. Floristic density and life form in mangrove had 121ha-1, 3 megaphanerophytes and mesophanerophytes respectively, in ecotone 1660ha-1, 9 megaphanerophytes, 24 mesophanerophytes and 39 microphanerophytes and in rainforest 574ha-1, 13 megaphanerophytes, 18 mesophanerophytes and 24 microphanerophytes. Highest frequency of occurrence: 1 species (80%), 4 species (100%) and 1 species (80%) in mangrove, ecotone and rainforest sites, respectively. Highest abundance: mangrove (1 species), ecotone (9 species) and rainforest (3 species). Highest density: mangrove (1 species), ecotone (8 species) and rainforest (3 species). Distribution: greater in ecotone with contiguous pattern in the order: ecotone>rainforest>mangrove, among which had dissimilarity in response to significant species diversity difference in relation to significant difference in edaphic physico-chemical factors of the study sites. The mangrove site had the most acidic pH, highest salinity, moisture and electrical conductivity while rainforest and ecotone had highest organic carbon and matter. A significant negative correlation between EC & pH, and salinity & pH and positive correlation between salinity & EC as well as positive correlation between pH & OC, pH & OM, OC & OM and negative correlation between EC & OC, EC & OM were recorded.
Conclusion: This variation determined the presence, growth and abundance of the species reported in the respective study sites especially in the ecotone.
A Comparison of the Effect on Postoperative Pain between Lateral Femoral Cutaneous Nerve Block and Local Infiltration Anesthesia after Total Hip Arthroplasty: A Randomized Trial
Authors: Shimasaki Ayako , Terao Yoshiaki , Komatsu Yuya , Kasai Yusuke , Oji Natsuko , Oji Makito , Aoki Hiroshi , Hara Tetsuya 
Published: December 2022

Aims: No gold standard for pain management after total hip arthroplasty (THA) exists. This prospective, randomized, open-label study aimed to determine whether lateral femoral cutaneous nerve block and local infiltration analgesia (LIA) were effective analgesic adjuvants to femoral nerve block (FNB) after THA.
Study Design: Prospective, randomized, open-label trial.
Place and Duration of Study: Department of Anesthesia, Nagasaki Rosai Hospital, Sasebo, Japan between April 2019 and May 2020.
Methodology: This study included 50 patients who underwent THA under total intravenous anesthesia using propofol. All patients received ultrasound-guided FNB using 0.25% levobupivacaine 20 mL before the operation. Patients were randomly allocated to one of the following two groups: Group B (n=25), which received ultrasound-guided lateral femoral cutaneous nerve block with 0.25% levobupivacaine 20 mL after FNB; and Group I (n= 25), which received 0.25% levobupivacaine 20 mL over the incision line into the muscle, and the subcutaneous, and cutaneous tissue along the wound edge after the fascia closure. All patients received 1000 mg intravenous acetaminophen before the end of the operation, and at 6, 12, 18, and 24 h after the operation. The patients received 50 mg of diclofenac sodium, as rescue analgesics, if needed. Nursing staff evaluated the postoperative pain using a numerical rating scale (NRS) at 0, 1, 3, 6, 12, 18, and 24 h postoperatively.
Results: No significant difference was observed in patient characteristics, except the operative time, between the groups. Additionally, no significant difference was found in NRS and in the frequency of rescue analgesics during the study period between the groups.
Conclusion: We concluded that both lateral femoral cutaneous nerve block and LIA with FNB would have the equivalent adjunctive analgesic effect after THA.
In-Hospital and Short-Term Outcomes of Percutaneous Coronary Intervention in Patients Older Than 65 Years Old: Results from Tanta PCI Registry
Authors: Kasem Mohammed Salah , Badr Seham Fahmy , Kassem Hanan Kamel , El-Amrosy Mahmoud Zaki , Abdel-Majid Randa Mohammed 
Published: December 2022

Background: Percutaneous coronary intervention (PCI) outcomes in elderly people are more challenging due to several factors. This study aimed to investigate in-hospital and short-term outcomes of PCI in elderly people aged more than 65 years old, presented to cardiology department of Tanta university hospitals during study period.
Methods: This case-control study was carried out on 935 patients presenting for elective PCI procedure and those suffering from high-risk ACS either ST segment elevation myocardial infarction (STEMI), non-ST segment elevation myocardial infarction (NSTEMI) or unstable angina treated with urgent PCI. Patients were divided into 4 groups: group II: included 326 patients aged from 65 to 69 years old, group III: included 160 patients aged from 70 to 74 years old, group IV: Included 99 patients aged ≥ 75 years old and group I (control): included 350 patients aged < 65 years old. All patients were subjected to ECG, echocardiography, basic labs, coronary angiography and PCI.
Results: Mortality, dissection, perforation, CIN, hemorrhage, heart failure and cardiogenic shock were significantly different among STEMI patients’ groups (P ≤ 0.05). CVS, Heart failure and Cardiogenic shock were significantly different among NSTE-ACS patients’ groups (P ≤ 0.05). Loss of follow up and mortality were significantly different among NSTE-ACS patients’ groups. Age, diabetes mellitus, hypertension, multi-vessel diseases, dissection, perforation and major bleeding were significant predictors of mortality among elective PCI patients (P ≤ 0.05). Age, diabetes mellitus, hypertension, chronic kidney diseases that necessitates dialysis, dyslipidemia multi-vessel diseases, left main artery, final TIMI 0, final TIMI I dissection, perforation, and major bleeding were significant predictors of mortality among ACS PCI patients (P ≤ 0.05).
Conclusions: In spite that PCI in elderly people still challenging, with poorer outcomes especially among those older than 75 years of age, newer generations of drug-eluting stents, and wide-availability of the safer radial artery access reduced the risk of PCI-related major adverse cardiovascular events and improved the long-term clinical outcomes in elderly patients suffering from both high-risk chronic and ACS.
Assessment of Mental Health Services Available Through Smartphone Apps
Authors: Camacho Erica , Cohen Asher , Torous John 
Published: December 2022

ImportanceAs more patients and clinicians are turning to mental health smartphone apps to expand access to services, little is known about the current state of the app marketplaces and what these apps are actually offering in terms of features, privacy, price, and services.ObjectiveTo assess the current state of mental health apps, explore the association between app privacy scores and popularity as measured by star ratings and downloads, and to understand opportunities and challenges facing the commercial app landscape.Design, Setting, and ParticipantsThis cross-sectional study had trained raters using the public-facing M-Health Index and Navigation Database (MIND) to assess and review 578 mental health apps. The sample of apps used in this analysis were pulled from MIND and include apps across various conditions including schizophrenia, eating disorders, sleep, and more. Analysis of these apps was conducted in June 2022.ExposuresThere were 578 mental health apps rated across 105 dimensions derived from the American Psychiatric Association’s app evaluation framework.Main Outcomes and MeasuresApp raters assessed each app across 6 categories: (1) app origin and accessibility, (2) privacy and security, (3) clinical foundation, (4) features and engagement, (5) inputs and outputs, and (6) interoperability. Privacy scores were determined by 5 MIND criteria, including (1) having a privacy policy, (2) reporting security measures in place, (3) declaring data use and purpose, (4) allowing for the deletion of data, and (5) allowing users to opt out of data collection. Correlations between privacy scores and popularity metrics (star ratings and number of downloads) were measured.ResultsThis study included 578 mental health apps that were identified, assessed, and analyzed across 105 MIND dimensions. Psychoeducation, goal setting, and mindfulness were among the top app features. Of the 578 apps analyzed, 443 (77%) had a privacy policy. This analysis of apps with a privacy policy revealed that there was no statistically significant correlation between privacy scores and Apple App Store (r = 0.058, P = .29) or Google Play Store star ratings (r = 0.041; P = .48). The number of app downloads on the Google Play Store, however, was weakly correlated with privacy scores (χ25 = 22.1; P &amp;lt; .001).Conclusions and RelevanceIn this cross-sectional study of mental health apps, findings indicate that the current app marketplaces primarily offered basic features such as psychoeducation, goal tracking, and mindfulness but fewer innovative features such as biofeedback or specialized therapies. Privacy challenges remained common, and app popularity metrics provided little help in identifying apps with more privacy.
Socioeconomic and Geographic Disparities in the Referral and Treatment of Pancreatic Cancer at High-Volume Centers
Authors: Sutton Thomas L. , Beneville Blake , Johnson Alicia J. , Mayo Skye C. , Gilbert Erin W. , Lopez Charles D. , Grossberg Aaron J. , Rocha Flavio G. , Sheppard Brett C. 
Published: December 2022

ImportanceTreatment at high-volume centers (HVCs) has been associated with improved overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC); however, it is unclear how patterns of referral affect these findings.ObjectiveTo understand the relative contributions of treatment site and selection bias in driving differences in outcomes in patients with PDAC and to characterize socioeconomic factors associated with referral to HVCs.Design, Setting, ParticipantsA population-based retrospective review of the Oregon State Cancer Registry was performed from 1997 to 2019 with a median 4.3 months of follow-up. Study participants were all patients diagnosed with PDAC in Oregon from 1997 to 2018 (n = 8026).ExposuresThe primary exposures studied were diagnosis and treatment at HVCs (20 or more pancreatectomies for PDAC per year), low-volume centers ([LVCs] less than 20 per year), or both.Main Outcomes and MeasuresOS and treatment patterns (eg, receipt of chemotherapy and primary site surgery) were evaluated with Kaplan-Meier analysis and logistic regression, respectively.ResultsEight thousand twenty-six patients (male, 4142 [52%]; mean age, 71 years) were identified (n = 3419 locoregional, n = 4607 metastatic). Patients receiving first-course treatment at a combination of HVCs and LVCs demonstrated improved median OS for locoregional and metastatic disease (16.6 [95% CI, 15.3-17.9] and 6.1 [95% CI, 4.9-7.3] months, respectively) vs patients receiving HVC only (11.5 [95% CI, 10.7-12.3] and 3.9 [95% CI, 3.5-4.3] months, respectively) or LVC-only treatment (8.2 [95% CI, 7.7-8.7] and 2.1 [95% CI, 1.9-2.3] months, respectively; all P &amp;lt; .001). No differences existed in disease burden by volume status of diagnosing institution. When stratifying by site of diagnosis, HVC-associated improvements in median OS were smaller (locoregional: 10.4 [95% CI, 9.5-11.2] vs 9.9 [95% CI, 9.4-10.4] months; P = .03; metastatic: 3.6 vs 2.7 months, P &amp;lt; .001) than when stratifying by the volume status of treating centers, indicating selection bias during referral. A total of 94% (n = 1103) of patients diagnosed at an HVC received HVC treatment vs 18% (n = 985) of LVC diagnoses. Among patients diagnosed at LVCs, later year of diagnosis and higher estimated income were independently associated with higher odds of subsequent HVC treatment, while older age, metastatic disease, and farther distance from HVC were independently associated with lower odds.Conclusions and RelevanceLVC-to-HVC referrals for PDAC experienced improved OS vs HVC- or LVC-only care. While disease-related features prompting referral may partially account for this finding, socioeconomic and geographic disparities in referral worsen OS for disadvantaged patients. Measures to improve access to HVCs are encouraged.
A comprehensive analysis of sit‐to‐stand movement in a living space involving principal component analysis
Authors: Haraguchi Naohiro , Ogawa Ami , Mita Akira 
Published: December 2022

AbstractSit‐to‐stand (STS) movement is a frequently performed activity of daily living. The analysis of STS movement can lead to the early detection of a decline in physical functioning. There is thus interest in home‐based STS monitoring systems. The present study (1) extracted universal differences by age group in common STS movements of daily life and (2) clarified where the differences between age groups lie in the sequence of movements. We experimented to measure the three patterns of STS movement assumed to be performed in living spaces. Ten young adults and seventeen elderly people participated. Data were acquired by an Azure Kinect DK, an RGB‐D camera, and converted into angles and angular velocities of the major body segments. Principal component analysis was applied to the overall time series data. From the synthesized principal component space, principal components with significant differences between the elderly and young‐adult groups were extracted, and the movements of the elderly participants were evaluated. We found parameters and movement strategies that show the characteristics of each age group for each movement pattern. The results of this study can contribute to the design of home‐based STS monitoring systems.
Tetrahymena
Authors: Cole Eric S 
Published: December 2022

AbstractTheTetrahymenagenus is composed of mostly free‐living ciliated protozoa that have helped researchers gain insight into fundamental problems of cell biology. As all ciliates,Tetrahymenacontain separate germline and somatic nuclei known as the micronucleus and macronucleus, respectively. The macronucleus is derived from a copy of the micronucleus through a process that involves extensive whole‐genome rearrangement and that is under intensive study.Tetrahymena thermophilacan be readily manipulated using the tools of genetics, molecular biology, cell biology and biochemistry. Recently, next‐generation, whole‐genome sequencing has made possible the identification of previously unidentified genes responsible for a rich gallery of mutant phenotypes. Notable discoveries made usingTetrahymenainclude the structure of telomeres and telomerase, self‐splicing RNA, the first microtubular motor, and the link between histone acetylation and gene regulation. The approximately 104 Megabase macronuclear genome ofT. thermophilahas been sequenced and annotated; the micronuclear genome has been sequenced as well.Key ConceptsTetrahymenaare large, complex eukaryotic cells well‐suited both for university research and for the undergraduate teaching‐laboratory.Tetrahymena,have been studied for nearly a century and have been the source of numerous ground‐breaking discoveries.Applying modern tools of genomics, proteomics, and next‐generation, whole‐genome sequencing has ushered in a new era of research to such topics as the assembly of basal bodies and cilia, pattern formation, novel roles for smallribonucleic acids(RNAs), membrane trafficking, secretion, phagocytosis, pinocytosis, cytoskeletal motility and chromosome dynamics including studies on the origins ofdeoxyribonucleic acid(DNA) replication, telomere synthesis, meiosis, recombination, apoptosis and the regulation of gene expression through epigenetic chromatin marking.Tetrahymenaoffer special insights into cell biological processes due to their many original and extraordinary capabilities including the use of a unique genetic code, novel twists on metabolism and protein trafficking, self‐splicing RNA, programmed genome rearrangement involved in genome surveillance, cortical patterning and cellular regeneration.Tetrahymena exhibit both conserved and evolutionarily divergent solutions to fundamental cell biological problems.