bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete Remission of a Patient With HER-2 amplification Gastric Cancer Treated With Sintilimab Combined With Trastuzumab
Authors: Ju Yuming , Zhu GuanYu , Wei Yuzhe , Wang Zeshen , Jin Shiyang , Cheng Qingqing , Wang Qiancheng , Liu Linghui , Liu Xirui , Li Zhenglong , Zheng Wangyang , Wang Kuan , Xing Jun 
Published: April 2023

Abstract
Background Gastric cancer (GC) is one of the most common malignant tumors in China and is also a major cause of cancer deaths worldwide, for which treatment strategies are extremely limited. Patients Susually lose the opportunity of therapeutic surgery because the lesions cannot be completely removed, although it can greatly prolong their survival time. Human epidermal growth factor receptor-2（HER-2）is the diagnostic criterion that determines whether patients can be the therapy with target in gastric cancer. However, the effect of targeted therapy on improving patient over survival (OS) is not significant. In recent years, immune checkpoint inhibitors (ICIs) sintilimab has shown significant efficacy in the treatment of gastric cancer.
Case presentation A 50-year-old man was diagnosed with adenocarcinoma of GC with multiple lymph node metastases. Positron emission tomography-computed tomography (PET-CT) shows retroperitoneal, ileocecal, ascending colon, pelvic peritoneum, and mesangial metastasis. Then, the patient underwent genetic testing.The results indicated that MSS, PD-L1 CPS = 2, HER-2(3+). Therefore, the first choice was chemotherapy combined with immunotherapy and targeted therapy. The regimen was chosen with sintilimab plus trastuzumab with chemotherapy SOX as first-line therapy for patients. After two cycles of treatment, the expression of CA199 was decreased, and lymph node metastases were smaller than before. The treatment was continued, and CT scans suggested complete response (CR) was achieved for both the lymph node metastases and gastric lesions after of 4 cycles treatment on 31 January 2023. Maintenance sintilimab plus trastuzumab was selected because of his stable CR status. During the treatment period, there was no occurrence of relatively serious adverse effects due to chemotherapy.
ConclusionHER-2-positive GC of patients who receives target combined with immune therapy may be an efficient and safe decision-making therapeutic choice. The case provides a treatment regimen for patients with HER-2-positive, whether to choose combination therapy as a new treatment regimen. This is the first reported case of gastric cancer with multiple lymph node metastases with complete remission with sintilimab plus trastuzumab.
Microbial communities on UV cabins in the dermatology service of a Spanish hospital: ecology and resistance to UV light and antibiotics
Authors: Molina-Menor Esther , Carlotto Nicolás , Vidal-Verdú Àngela , Pérez-Ferriols Amparo , Pérez-Pastor Gemma , Porcar Manuel 
Published: April 2023

Abstract
Microorganisms colonize all possible ecological habitats, including those subjected to harsh stressors such as UV radiation. Hospitals, in particular the UV cabins used in phototherapy units, constitute an environment in which microbes are intermittently subjected to UV irradiation. This selective pressure, in addition to the frequent use of antibiotics by patients, may represent a threat in the context of the increasing problem of antimicrobial resistance. In this work, a collection of microorganisms has been established in order to study the microbiota associated to the inner and outer surfaces of UV cabins and to assess their resistance to UV light and the antibiotics frequently used in the Dermatology Service of a Spanish hospital. Our results show that UV cabins harbor a relatively diverse biocenosis dominated by typically UV-resistant microorganisms commonly found in sun-irradiated environments, such as Kocuria, Micrococcusor Deinococcus spp., but also clinically relevant taxa, such as Staphylococcusor Pseudomonas spp. The UV-radiation assays revealed that, although some isolates displayed some resistance, UV is not a major factor shaping the biocenosis living on the cabins, since a similar pool of resistant microorganisms was identified on the external surface of the cabins. Interestingly, some Staphylococcus spp. displayed resistance to one or more antibiotics, although the hospital reported no cases of antibiotic-resistance infections of the patients using the cabins. Finally, no association between UV and antibiotic resistances was found.
Dual-scale chemical ordering enables exceptional cryogenic mechanical properties of medium-entropy alloys
Authors: Raabe Dierk , Lu Tiwen , Sun Binhan , Dai Sheng , Li Yue , Ye Fan , Niu Jiacheng , Silva Alisson Kwiatkowski da , Deng Sihao , Xie Yu , Yao Ning , Tan Jianping , He Tianbing , Ponge Dirk , He Lunhua , Zhang Xiancheng , Tu Shan-Tung 
Published: April 2023

Abstract
The mechanical properties of metallic materials often significantly deteriorate when used under harsh conditions, particularly at cryogenic temperatures. Yet, safe and lasting low-temperature infrastructures are needed to realize the growing global demand for liquid energy carriers such as hydrogen[1]. Traditional microstructure strategies designed for high strength and ductility at room temperature often fail when exposed to such low temperatures due to the unresolved conflict between strength and damage tolerance under such conditions[2, 3]. Here we introduce a new type of dual-scale atomic ordering nanostructure embedded in a massive metallic solid solution matrix to overcome this challenge. This reconciles advantages of two antagonistic mechanisms in one material concept, namely, a well-balanced enthalpy-driven ordering on the one hand and entropy-driven solid solution on the other. We realize the approach in form of an exceptionally high number density of coexisting sub-nanoscale chemical short-range ordered (SRO, ~2.4×10^26 m-3) and nanoscale long-range ordered (NLRO, ~4.5×10^25 m-3) zones in a CoNiV-based compositionally complex alloy. We observe several types of interactions between the chemical ordering and the dislocations, i.e., the defects that carry both, the material’s inelastic deformation and potentially also its damage initiation. We observe an ordering-induced increase in dislocation shear stress (providing strength) as well as a more rapid dislocation multiplication due to the frequent blocking of the planar dislocation flux by NLRO and the associated generation of new dislocations (providing ductility). The latter effect also releases stress concentrations at NLRO obstacles that otherwise would promote damage initiation and failure (a phenomenon observed in materials with larger ordered zones and precipitates). Consequently, a higher strength-ductility combination (strength-elongation product 76.5 GPa% with 1172 MPa yield strength at 87 K) is achieved in comparison to reference materials devoid of such ordering hierarchy (yield strength 794 MPa), containing only SRO (yield strength 931 MPa) or coherent precipitates of a few tens of nanometers (strength-elongation product 38.8 GPa%). Our results thus reveal the effects of different types (and scales) of coexisting chemical ordering on mechanical properties of complex alloys and provide guidelines to control them, which serves as a new design approach for strong and tough materials particularly for cryogenic applications.
FTH1 protects against osteoarthritis by inhibits ECM degradation via the MAPK pathway
Authors: Yuan Zhikun , Yang Lingfeng , Li Yanhui , Li Xuming , Peng Changgui , Zhang Haiyan , Cai Daozhang , Pan Jianying 
Published: April 2023

Abstract
Ferritin heavy chain 1, which FTH codes, is an important subunit of ferro-storing proteins and is indispensable in iron metabolism. It has been extensively researched in numerous organs and illnesses. Nevertheless, the relationship between FTH1 and osteoarthritis (OA) remains unclear. Here, we highlighted the significance of FTH1 in the pathophysiology of OA and identified it as a critical mediator of chondrocyte senescence and extracellular matrix(ECM) degradation. We discovered that FTH1 expression was downregulated in OA patients as well as mice after destabilized medial meniscus surgery (DMM). Knocking down of FTH1 caused articular cartilage damage and extracellular matrix degradation in cartilage explants. Furthermore, increased FTH1 expression can lessen the susceptibility of chondrocytes to ferroptosis, and reversed the decreased of SOX9 and aggrecan after DMM surgery in mice. The further study demonstrated that FTH1 relieved osteoarthritis by inhibiting the MAPK pathway in chondrocytes. Our study proved that FTH1 played an essential role in extracellular matrix degradation, ferroptosis and chondrocytes senescence during OA procedure, and intra-injection of adenovirus expressing FTH1 perhaps a viable and potential strategy for OA prevention and therapy.
Vaccination with intravenous BCG protects macaques with pre-existing SIV infection from tuberculosis
Authors: Larson Erica , Ellis-Connell Amy , Rodgers Mark , Gubernat Abigail , Gleim Janelle , Moriarty Ryan , Balgeman Alexis , Ameel Cassaundra , Jauro Solomon , Tomko Jaime , Kracinovsky Kara , Maiello Pauline , Borish Henry , White Alexander , Klein Edwin , Bucsan Allison , Darrah Patricia , Seder Robert , Mason Rosemarie , Lin Philana , Flynn JoAnne , O'Connor Shelby , Scanga Charles 
Published: April 2023

Abstract
Tuberculosis (TB) is the most common cause of death in people living with HIV. BCG delivered intradermally (ID) is the only licensed vaccine to prevent TB. However, it offers little protection from pulmonary TB in adults. Intravenous (IV) BCG, but not ID BCG, confers striking protection against Mycobacterium tuberculosis (Mtb) infection and disease in rhesus macaques. We investigated whether IV BCG could protect against TB in macaques with a pre-existing SIV infection. There was a robust influx of airway T cells following IV BCG in both SIV-infected and SIV-naïve animals, with elevated antibody titers in plasma and airways. Following Mtb challenge, all 7 SIV-naïve and 9 out of 12 SIV-infected vaccinated animals were completely protected, without any culturable bacilli in their tissues. PBMC responses post-challenge indicated early clearance of Mtb in vaccinated animals regardless of SIV infection. These data support that IV BCG is immunogenic and efficacious in SIV-infected animals.
Comparative study of turning two engineering plastics (POM-C and PA-6) and optimisation using GA, SA, GRA and COPRAS with and without weighting (Entropie, critic, Swara, ROC)
Authors: Kaddeche Mounia , Boucherit Septi , Belhadi Salim , Yallesse Mouhamed A. 
Published: April 2023

Abstract
This paper focuses on a comparative study of the machinability of two semi-crystalline polymers (POM-C) and (PA-6), during dry turning operations. The aim is to experimentally examine the impact of cutting parameters, namely cutting speed, feed, and depth of cut on surface roughness, cutting force, cutting power, and material removal rate. A series of experiments according to a Taguchi L18 plan was implemented. The ANOVA analysis revealed that the type of material a substantial effect on surface roughness, followed by feed, whereas cutting force and cutting power are more affected by depth of cut. Linear regression models with interactions proved effective in predicting the studied responses, and single-objective optimization using SA and GA methods were applied to optimize each response. The GRA and COPRAS methods coupled with weighting methods CRITIC, ROC, SWARA, and Entropy are used for multi-objective optimization of the considered responses. The results showed that the combination of the COPRAS method with the SWARA method provides a better compromise, which is of crucial interest for researchers in the field of optimization in polymer material machining.
Protective effect of polysaccharides isolated from Sargassum horneri against H 2 O 2 -induced oxidative stress in vitro in Vero and in vivo in zebrafish
Authors: Wei Shuang-yan , Wang Li , Yang Jia , Xu Rui-hang , Tong Yu-pei , Jia Rui 
Published: April 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Fabrication and characterization of antimicrobial hybrid electrospun polyvinylpyrrolidone/kafirin nanofibers activated by Zataria Multiflora essential oil
Authors: Abdollahi-Kazeminezhad Nazila , Esmaiili Mohsen , Almasi Hadi , Hamishehkar Hamed 
Published: April 2023

Abstract
Nanofiber films were prepared using a polymer blend of kafirin and polyvinylpyrrolidone (PVP) by electrospinning. The zataria multiflora boiss. essential oil (ZEO) was encapsulated in the electrospun nanofibers and the morphology, structural characteristics, thermal, antibacterial and release properties were investigated. The concentrations of ZEO selected for addition to the polymer solution were 7, 10 and 15% (v/v). It was found that the produced electrospun nanofibers, regardless of ZEO concentration, possessed a homogeneous morphology without beads and there was a positive correlation between ZEO addition and nanofiber diameter. Moreover, the electrospun nanofibers were found to be effective carriers of ZEO and were able to control the release of compounds. The nanofibers exhibited antibacterial activity against common foodborne bacteria (Listeria monocytogenes, Staphylococcus aureus, Escherichia coli 0157:H7, Salmonella enterica, and Pseudomonas aeruginosa). The fiber prepared with 15% (v/v) ZEO was the most effective against all microorganisms tested. The Fick model, was used to describe the release profiles of ZEO at different temperatures (4, 25 and 37 °C) and with different food simulants (50 % and 98 % ethanol). The findings revealed that diffusion phenomenon plays an increasingly important role in the delivery of ZEO. It is believed that the developed nanofibers have potential applications in active food packaging to reduce microbial contamination.
Hematological damage and risk factors prediction in HIV-infected patients with secondary malignancies：A single-center study from China
Authors: Tang Ping , Zhang Nan , Chen Guopeng , Lv Xiaoyan , Shen Hui , Li Pengpeng , Pang Wenwen , Zhou Fuling 
Published: April 2023

Abstract

Purpose The incidence and mortality of secondary malignant tumors (MT) in people living with HIV(PLWH) are increasing. The purpose of this study is to analyze the characteristics of Complete Blood Count (CBC), bone marrow and immunity in PLWH with secondary MT, so as to provide data reference for diagnosis and risk factor assessment strategies of such patients.Methods We collected 297 patients who were diagnosed with PLWH and required bone marrow examination, including 101 cases of PLWH with secondary MT and 196 cases of PLWH without MT. The CBC, bone marrow and immune index of the two groups of patients were retrospectively analyzed.Results In terms of WBC, RBC, HGB, PLT, NEUT, the granulocyte ratio in bone marrow and CD4 cell counts, both were lower than those of pure PLWH. The independent risk factors of PLWH with secondary MT were HGB < 90g/L (RR = 1.581, 95%CI: 1.030–2.427, P = 0.036), the morphology of RBC in BM showed senescent nuclei and immature cytoplasm (RR = 1.489, 95%CI: 1.006–2.203, P = 0.046) and CD4 cell count < 100 cells/ul (RR = 2.307, 95%CI: 1.406–3.787, P = 0.001). HGB < 60g/L and RBC ratio of bone marrow < 0.2 were the independent risk factors associated with prognosis. The best hematologic predictor of PLWH with secondary MT was HGB (AUC = 0.707, 95%CI: 0.642–0.772, P < 0.001).Conclusion Severe anemia, the abnormal morphology of RBC in bone marrow, severe immune deficiency increase the risk of secondary MT in PLWH. Severe anemia and decreased RBC ratio in bone marrow are independent factors affecting the prognosis of PLWH with secondary MT.
Light is one- dimensional transverse wave
Authors: Tian Yunchuan 
Published: April 2023

Abstract
When particles traverse a medium, they invariably undergo scattering by electrons, resulting in a decrease in transmittance as the thickness of the medium increases. However, in the experiments conducted, the transmittance of light increased even when the angle of incidence increased, and the thickness of the medium tripled. This outcome is unattainable for particles . Furthermore, a series of experiments verified that light manifest as transverse waves on a one-dimensional string . These experimental results can be attributed to the interaction between the amplitude of light and the medium of electrons. Employing the novel refractive-index formula, the refractive indices of gases such as helium, oxygen, and chlorine were calculated with remarkable precision.
Mining Parallel Sentences from Internet with Multi-view Knowledge Distillation for Low-resource Language Pairs
Authors: Zhu Shaolin , Li Shangjie , Gu Shiwei , Xu Lin 
Published: April 2023

Abstract
The neural machine translation (NMT), which relies on a large training data (bilingual parallel sentences, for NMT) to obtain the state-of-the-art performance, is similar with deep learning. In order to construct NMT systems, the number of parallel sentences is very important. However, these bilingual resources are scare to many low-resource language pairs. Although several works attempt to obtain bilingual parallel data from Internet, the quality and quantity of mined bilingual corpus are limited for low-resource language pairs. To address this problem, we propose the multi-view knowledge distillation model (MvKD) that use the knowledge of high-resource language pairs transfer into low-resource languages by leveraging internal language-invariant cross different languages. In particular , we treat the mining bilingual parallel sentence pair task as classifying task and use the multi-view classifier to detect bilingual parallel sentence pair. For multi-view classifier, we use two views to recognize the semantic difference of two sentences:(i) word-level representations (ii) sentence-level representations. We encode sentence-level representations to capture semantically similar of two sentences. Moreover, we encode word-level representations to capture word translations in a pair of parallel sentences to avoid the problem that semantically similar but non-parallel sentences. Experimental results demonstrate that our proposed method can significantly mine amount of bilingual corpus and improve the quality of parallel sentences. In particular, we carry out the experiments on several real-world low-resource situations and achieve excellent results.
Enhancing enterprise risk management (ERM) practices through a risk-driven performance measurement system (PMS): insights from a SME case study
Authors: Bettanti Alberto , Lanati Antonella 
Published: April 2023

Abstract
The relationship between enterprise risk management (ERM) and performance measurement systems (PMS) has garnered increased attention in recent years, as the adoption of ERM frameworks has become more widespread among both large corporations and small to medium-sized enterprises (SMEs). Despite this, there remains a dearth of research on this topic. In this paper, we aim to explore the synergies between risk management and performance management. Through a literature review, it becomes apparent that these two areas have significant potential for alignment, yet this potential remains untapped due to a lack of appropriate management tools and organizational structures to connect them. Our theoretical analysis serves as the foundation for a comprehensive case study examination of the relationship between risk and performance in the context of building a risk-driven PMS in SMEs. Utilizing the grounded theory methodology, a suitable case study was selected among SMEs, and a risk-driven PMS framework was applied in order to address the research question. This inductive-empirical methodology aims to test the assumptions that ERM is often a challenging practice to implement within SMEs and that linking ERM to PMS can help to bolster risk management initiatives within SMEs.
In conclusion, this paper contributes to the existing literature by presenting a case-study based conceptual model of the link between risk and performance, which can serve as a useful tool and managerial practice for enterprise risk managers in identifying risks and facilitating business growth.
Evaluation of the cytotoxic effect of GaFe2O4@Ag magnetic nanocomposite biosynthesized by Spirulina platensis on breast cancer cell line and evaluation of BAX, Bcl-2, CASP9 and MMP1 genes expression
Authors: Mehraban Fatemeh , Esfahani Fariba Heidari , Dorcheh Zahra Mosayebi , Esfahani Erfaneh Heidari , Azadeh Mansoureh , Salehzadeh Ali 
Published: April 2023

Abstract
Treating breast cancer is hardly achieved and finding efficient anticancer nanocompounds has gained great attention. In this work, the cytotoxic effect of GaFe2O4@Ag nanocomposite biosynthesized by Spirulina platensis on breast cancer cell line and expression of the BAX, Bcl-2, CASP9 and MMP1 (Matrix Metallopeptidase 1) genes were evaluated. Physicochemical features of the nanocomposite were determined using the FT-IR, XRD, SEM, TEM, EDX-mapping, VSM, Zeta potential, and DLS analyses. The cytotoxic effect of the nanocomposite for MCF-7 and HEK-293 cells was evaluated by the MTT assay. Flow cytometry analysis, Caspase-3 activation assay, and Hoechst staining were performed to evaluate the apoptosis induction potential of the nanocomposite. Further, the relative expression of the Bcl-2, BAX, and CASP9 genes was determined by quantitative PCR assay. The prepared nanocomposite was spherical with a size range of 35–60 nm. The hydrodynamic size and zeta potential of the nanocomposite were 328 nm and − 31.8 mv, respectively. GaFe2O4@Ag nanocomposite had a higher cytotoxic effect on breast cancer cells than normal human cells with the IC50 of 18.6 and 220 µg/mL, respectively. Treating breast cancer cells with the nanocomposite induced apoptosis among 85.2% of cells, increased caspase-3 activity by 4.3 folds, and caused apoptotic nuclear changes. Also, GaFe2O4@Ag reduced the expression of the Bcl-2 and MMP1 by 1.3 and 0.6 folds and up-regulated the BAX and CASP9 genes by 2.7 and 2.65 folds, respectively. Our results revealed that GaFe2O4@Ag was highly cytotoxic for breast cancer cells via triggering apoptosis pathways and could be considered as a novel and efficient agent against breast cancer, after further in-vivo experiments.
Numerical model of the Shear Stress Variations with the groundwater level variations
Authors: Doan Thy 
Published: April 2023

Abstract
Numerical model (PLAXIS 3D or finite element method) of the Shear Stress Variations with the groundwater level variations presented by the Viet Nam Standard “TCVN 4195:2012”. Results show the value of the maximum shear stress show τmax = 150.7 kN/m2 at Depth 5.0m; τmax = 159.7 kN/m2 at depth 8.0m; τmax = 192.6 kG/cm2 at depth 15.0m; τmax = 219.4 kN/m2 at depth 27.0m. The shear stress increase gradually with the increasing of depths with the constant loading Psn = 50 kN/m2. At the 5.0m; 8.0m; 15.0m; 27.0m depth, the deviation shows the value of 72.7 kN/m2; 72.7 kN/m2; 41.6 kN/m2; 27.1 kN/m2; 91.8 kN/m2. This deviation is very big between the experiment and simulation.