bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Dual‐Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis
Authors: Su Wen , Qiu Wei , Li Shu‐Jin , Wang Shuo , Xie Jun , Yang Qi‐Chao , Xu Jiming , Zhang Junjie , Xu Zhigang , Sun Zhi‐Jun 
Published: December 2022

AbstractImmune checkpoint blockade (ICB) therapy shows excellent efficacy against malignancies; however, insufficient tumor immunogenicity and the immunosuppressive tumor microenvironment (TME) are considered as the two major stumbling blocks to a broad ICB response. Here, a combinational therapeutic strategy is reported, wherein TME‐reactive oxygen species/pH dual‐responsive signal transducers and activators of transcription 3 inhibitor nanoprodrugs MPNPs are combined with oncolytic herpes simplex virus 1 virotherapy to synergistically ignite pyroptosis for enhancing immunotherapy. MPNPs exhibit a certain level of tumor accumulation, reduce tumor cell stemness, and enhance antitumor immune responses. Furthermore, the simultaneous application of oncolytic viruses (OVs) confers MPNPs with higher tumor penetration capacity and remarkable gasdermin‐E‐mediated pyroptosis, thereby reshaping the TME and transforming “cold” tumors into “hot” ones. This “fire of immunity” strategy successfully activates robust T‐cell‐dependent antitumor responses, potentiating ICB effects against local recurrence and pulmonary metastasis in preclinical “cold” murine triple‐negative breast cancer and syngeneic oral cancer models. Collectively, this work may pave a new way and offer an unprecedented opportunity for the combination of OVs with nanomedicine for cancer immunotherapy.
Remote housing for Indigenous children in the Fitzroy Valley, Western Australia: A case study
Authors: Dockery Alfred M. , Sykes Erica 
Published: December 2022

AbstractPoor‐quality and overcrowded housing in remote communities in Australia is widely seen to negatively impact Indigenous children's health and development. Despite widespread reports of, in some instances, quite appalling housing conditions, recent analyses of data from the Longitudinal Study of Indigenous Children (LSIC) found little evidence of adverse housing effects for Indigenous children living in very remote Australia. Given the apparent inconsistency in evidence coming from representative survey data and other accounts, a small‐scale case study was conducted in the Kimberley's Fitzroy Valley to gain greater insights into housing in very remote communities for families with school‐aged children. The LSIC very remote sample is confirmed to offer a good representation of housing conditions in these communities, based on replication of key housing data items in a small survey of Fitzroy Valley parents. While not apparent in those parent surveys, problems of severe overcrowding were highlighted in interviews with community leaders. Other issues raised included delays in maintenance and repairs and a lack of local input into housing management and associated employment, which was seen to disempower communities.
Comparison of risk factors for dementia among rural and urban elderly adults‐data from two cohort studies in India
Authors: Menesgere Abhishek , Sundarakumar Jonas S. , Shahul Hameed Shafeeq K. ,   SANSCOG & TLSA Study Teams, Ravindranath Vijayalakshmi 
Published: December 2022

AbstractIntroductionStudies on risk factors for dementia in India, especially rural India, are sparse and therefore we aimed to assess risk factors in a rural cohort on aging and compare it with an urban cohort.MethodsWe are presenting baseline data on proportion of hypertension, diabetes, obesity, physical inactivity, and Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) scores in both cohorts.ResultsThe rural cohort is younger and less educated than the urban cohort. The chi‐square test showed that the proportion of participants with hypertension, diabetes, and obesity was lower in the rural cohort, whereas physical inactivity was higher in comparison with the urban cohort; however, the proportion of high‐risk CAIDE scores was higher in the rural cohort.DiscussionDespite the rural cohort having a smaller proportion of participants with hypertension, diabetes, and obesity, the overall CAIDE score was higher—the main reason for this is low educational level.
Alzheimer's disease and related dementias among aging veterans: Examining gene‐by‐environment interactions with post‐traumatic stress disorder and traumatic brain injury
Authors: Logue Mark W. , Miller Mark W. , Sherva Richard , Zhang Rui , Harrington Kelly M. , Fonda Jennifer R. , Merritt Victoria C. , Panizzon Matthew S. , Hauger Richard L. , Wolf Erika J. , Neale Zoe , Gaziano J. Michael ,   the Million Veteran Program
Published: December 2022

ABSTRACTIntroductionPost‐traumatic stress disorder (PTSD) and traumatic brain injury (TBI) confer risk for Alzheimer's disease and related dementias (ADRD).MethodsThis study from the Million Veteran Program (MVP) evaluated the impact of apolipoprotein E (APOE) ε4, PTSD, and TBI on ADRD prevalence in veteran cohorts of European ancestry (EA; n = 11,112 ADRD cases, 170,361 controls) and African ancestry (AA; n = 1443 ADRD cases, 16,191 controls). Additive‐scale interactions were estimated using the relative excess risk due to interaction (RERI) statistic.ResultsPTSD, TBI, and APOE ε4 showed strong main‐effect associations with ADRD. RERI analysis revealed significant additive APOE ε4 interactions with PTSD and TBI in the EA cohort and TBI in the AA cohort. These additive interactions indicate that ADRD prevalence associated with PTSD and TBI increased with the number of inherited APOE ε4 alleles.DiscussionPTSD and TBI history will be an important part of interpreting the results of ADRD genetic testing and doing accurate ADRD risk assessment.
Controlling orientation, polymorphism, and crystallinity in thin films of poly(lactic‐acid) homopolymer and stereocomplex aligned by high temperature rubbing
Authors: Brosset Marion , Herrmann Laurent , Kiefer Céline , Falher Thierry , Brinkmann Martin 
Published: December 2022

AbstractHigh temperature rubbing is a fast and low‐cost method that can align semi‐crystalline polymers such as poly(lactic acid) (PLA) by application of a shear‐force via a rotating cylinder covered with a microfiber cloth on a thin film maintained at high temperature. A multi technique approach uncovers the role of rubbing temperature and film thickness on the PLA thin film structure. Both poly(l‐lactic acid) (PLLA) and the stereo‐complex (SC‐PLA) can be readily aligned by high temperature rubbing. The rubbing temperature TR and the film thickness are the key parameters that control polymorphism, in‐plane orientation, crystallinity and contact plane of the polymer crystals. Rubbing PLLA films in the range 80–140°C affords different aligned polymorphs (mesophase, α′, α′ + α mixtures and pure α phase) depending on the rubbing temperature. Pure α form of PLLA with 53% crystallinity is obtained at TR = 140°C whereas pure oriented crystalline SC‐PLA films are obtained by rubbing at 200°C.
Utilizing the metaverse in anatomy and physiology
Authors: Moro Christian 
Published: December 2022

AbstractOf the many disruptive technologies being introduced within modern curricula, the metaverse, is of particular interest for its ability to transform the environment in which students learn. The modern metaverse refers to a computer‐generated world which is networked, immersive, and allows users to interact with others by engaging a number of senses (including eyesight, hearing, kinesthesia, and proprioception). This multisensory involvement allows the learner to feel part of the virtual environment, in a way that somewhat resembles real‐world experiences. Socially, it allows learners to interact with others in real‐time regardless of where on earth they are located. This article outlines 20 use‐cases where the metaverse could be employed within a health sciences, medicine, anatomy, and physiology disciplines, considering the benefits for learning and engagement, as well as the potental risks.
Operational Validation of a Power Distribution Algorithm for a Modular Megawatt Battery Storage System
Authors: Koltermann Lucas , Jacqué Kevin , Figgener Jan , Zurmühlen Sebastian , Sauer Dirk Uwe 
Published: December 2022

AbstractLarge‐scale battery storage systems have become popular for various grid services in recent years. A worldwide market growth for battery storage has led to increased competition in several grid service markets. Modular large‐scale battery storage systems require a safe, highly available, and intelligent energy management system (EMS) in order to be economically competitive. One component of this EMS is the control for distributing the power requests between individual battery units of the large‐scale battery storage system. As the EMS is usually undisclosed intellectual property of the system manufacturers, there is only little information on real‐world operation available. To contribute, we present a rule‐based power distribution algorithm (SPDA) in this paper and validate it through field tests on a 6 MW/7.5 MWh system that is providing frequency containment reserve to the German power grid. The results show that especially when combining different battery technologies, the SPDA can exploit individual technological strengths. In this way, the state of charge of the batteries, energy throughput and power load of the batteries can be controlled to extend the lifetime. Moreover, the SPDA managed to shift nearly 80 % of the energy throughput to one battery unit to protect less cyclic stable batteries and make use of the advantage of cyclic stable battery technologies, while fulfilling all grid service requirements. By shifting those large quantities of the energy throughput to more cyclic stable battery units, the large‐scale battery storage system experienced in sum up to 45 % less cyclic aging with the SPDA than with a symmetrical power distribution algorithm. Furthermore, the operational efficiency of a large‐scale battery storage system can be significantly improved via additional software adaptations of the power distribution, depending on the system layout.
Synthesis and biological investigation of protein phosphatase 2A‐activating compounds with dimeric tail as non‐small cell lung cancer cell death agents
Authors: Kim Su Bin , Lee Taeho , Oh Yoon Sin , Park Eun‐Young , Baek Dong Jae 
Published: December 2022

AbstractFTY720 exerts an anticancer effect through the activation of protein phosphatase 2A (PP2A), which acts as a tumor suppressor, and inhibits SK1 activity. However, FTY720 taken into the body is phosphorylated by endogenous SK2. The structure of FTY720 is well‐studied as a basis for developing SK inhibitors and PP2A activators. We synthesized analogs of PF‐543 with a dimeric tail structure and reported the efficacy of SK1 inhibition. The compounds with this structure had improved anticancer activity and stability compared with PF‐543. To confirm whether the dimeric tail structure could be applied as a PP2A‐active material, we synthesized four types of compounds with a dimeric tail structure and confirmed the anticancer activity and PP2A activation in A549 non‐small cell lung cancer cells. Compounds 2 and 4 were more cytotoxic to A549 cells than RB005, and induced similar levels of cytotoxic and PP2A activation as FTY720.
Sustainable development and greenwashing: How blockchain technology information can empower green consumers
Authors: Nygaard Arne , Silkoset Ragnhild 
Published: December 2022

AbstractThe unethical behavior of greenwashing threatens the growth of sustainable products and markets. Greenwashing degrades essential efforts to reduce climate change and pollution and to promote social justice. False marketing communication that claims products are sustainable hurts the value of green products and weakens customer capability to prefer sustainable to nonsustainable products. Greenwashing also eliminates trust in “green” products. Markets infected by fake “green” products ultimately fail to provide the necessary sustainable transformation. Our study demonstrates that consumer access to reliable transparent, traceable, and tamperproof product information counteracts perceived greenwashing among consumers of ecological foods. Furthermore, our data indicate that blockchain information significantly more than certification systems safeguard consumers against the threat of greenwashing. Information validating authenticity promotes the development of sustainable products, protects intellectual property rights for suppliers of green products, and safeguards the supply of green products to consumers. Consumers need key information that ensures the provenance of green products. Conventional wisdom endorses certifications to constrain greenwashing. However, we find that blockchain information dimensions protect brands against perceived greenwashing more robustly than certification systems.
Identification of Genes Essential for Fluorination and Sulfamylation within the Nucleocidin Gene Clusters of Streptomyces calvus and Streptomyces virens
Authors: Wojnowska Marta , Feng Xuan , Chen Yawen , Deng Hai , O'Hagan David 
Published: December 2022

AbstractThe gene cluster in Streptomyces calvus associated with the biosynthesis of the fluoro‐ and sulfamyl‐metabolite nucleocidin was interrogated by systematic gene knockouts. Out of the 26 gene deletions, most did not affect fluorometabolite production, nine abolished sulfamylation but not fluorination, and three precluded fluorination, but had no effect on sulfamylation. In addition to nucI, nucG, nucJ, nucK, nucL, nucN, nucO, nucQ and nucP, we identified two genes (nucW, nucA), belonging to a phosphoadenosine phosphosulfate (PAPS) gene cluster, as required for sulfamyl assembly. Three genes (orf(−3), orf2 and orf3) were found to be essential for fluorination, although the activities of their protein products are unknown. These genes as well as nucK, nucN, nucO and nucPNP, whose knockouts produced results differing from those described in a recent report, were also deleted in Streptomyces virens – with confirmatory outcomes. This genetic profile should inform biochemistry aimed at uncovering the enzymology behind nucleocidin biosynthesis.
Enhanced Production of Liquid Alkanes from Waste Polyethylene via the Electronic Effect‐Favored Csecondary−Csecondary Bond Cleavage
Authors: Lu Shenglu , Jing Yaxuan , Jia Shengchao , Shakouri Mohsen , Hu Yongfeng , Liu Xiaohui , Guo Yong , Wang Yanqin 
Published: December 2022

AbstractCatalytic hydrogenolysis of polyethylene to liquid alkanes has drawn particular attention. However, it remains not very clear about the factors influencing the positions (internal Csecondary−Csecondary and terminal Csecondary−Cprimary bonds) of C−C bond cleavage. Here, we clarify the influence of Ru chemical state on the positions of C−C bond cleavage by designing two Ru/CeO2 catalysts with different Ru chemical states tuned by the metal‐support interaction. It is found that the positively charged Ru species favor the hydrogenolysis of the internal Csecondary−Csecondary bond, inhibiting methane production, because these Ruδ+ species enable the selective bonding with the internal Csecondary containing higher electron density through the electron‐donating effect of adjacent alkyl species instead of the terminal Cprimary. Furthermore, a simple Ru/CeO2−I catalyst with plenty of Ruδ+ species was designed and was efficient for the hydrogenolysis of real waste polyethylene plastics. This work would guide catalyst design to enhance the selective production of liquid alkanes.
Single Electrochemical Impacts of Shewanella oneidensis MR‐1 Bacteria for Living Cells Adsorption onto a Polarized Ultramicroelectrode Surface
Authors: Smida Hassiba , Lefèvre François‐Xavier , Thobie‐Gautier Christine , Boujtita Mohammed , Paquete Catarina M. , Lebègue Estelle 
Published: December 2022

AbstractSingle electrochemical impacts of Shewanella oneidensis MR‐1 Gram‐negative electroactive bacteria onto ultramicroelectrode surfaces are reported and in‐depth analysed. Chronoamperometry measurements recorded onto 10 μm‐diameter Pt and 7 μm‐diameter carbon fibre disk ultramicroelectrodes in a 20 mM potassium ferrocyanide aqueous solution in the presence of living bacteria show an electrostatic attraction of Shewanella cells onto the ultramicroelectrode surface polarized at +0.8 V vs Ag/AgCl. Single current step events analysis and atomic force microscopy experiments confirm the adsorption of living bacteria following the collision onto the ultramicroelectrode surface. The bacteria washing step before the chronoamperometry measurements leads to lower current step events related to the smaller size of the living cells. The electrostatic attraction of the negatively charged bacteria onto the positively charged ultramicroelectrode surface polarized at the oxidation potential of ferrocyanide is clearly demonstrated.
Modulating the Electrochemical Response of Eco‐Friendly Laser‐Pyrolyzed Paper Sensors Applied to Nitrite Determination
Authors: Gongoni Juliana L. M. , Filho Lauro A. P. , De Farias Davi M. , Arantes Iana V. S. , Paixão Thiago R. L. C. 
Published: December 2022

AbstractMiniaturized paper‐based electrochemical sensors were fabricated using kraft paper and CO2 laser, dispensing the need for chemical reagents and controlled atmospheric conditions. This study initially evaluated the paper type and laser processing parameters, enhancing the electrodes′ robustness, electrochemical response, and electrical resistance. The sensors were also treated by applying −1 V for 60 s in 1.0 mol L−1 KCl, which is a simple and rapid procedure. The electrochemical treatment increased the electroactive area and roughness, confirmed by scanning electron microscopy. These aspects helped modulate the sensors′ electrochemical response for nitrite determination, improving selectivity and sensitivity for this compound. The sensors also showed repeatability and batch‐to‐batch reproducibility, with 2.2 and 10 % RSD, respectively. Therefore, this work brings a protocol to fabricating competitive electrochemical sensors through a sustainable strategy, opening possibilities for designing new analytical systems.
Tuning Energy Transfer in Metal‐Organic Frameworks for Fluorescence Turn‐on Sensing of Hg(II) Ions†
Authors: Wang Xuejiao , Mal Arindam , Gui Bo , Wang Cheng 
Published: December 2022

Comprehensive SummaryTuning Förster resonance energy transfer (FRET) in metal‐organic frameworks for fluorescence turn on sensing is rarely reported. Herein, we designed and synthesized several FRET‐based metal‐organic frameworks (MOFs) with different donor/acceptor ratios. Through the oxidation of the acceptor, the FRET process in MOFs can be efficiently modulated so as to turn‐on the fluorescence of the framework in a controlled manner. Interestingly, the MOF with an optimized donor/acceptor ratio of 7.0 was used as an efficient fluorescence turn on sensor for Hg(II) ions with good sensitivity and selectivity. We believe our present study will not only give a useful method to construct fluorescence turn‐on sensors but also trigger the construction of novel FRET‐based MOFs for the fluorescence turn‐on sensing of target analytes in the future.
Highly Luminescent Blue Emitter with Balanced Hybridized Locally and Charge‐Transfer Excited‐States Emission
Authors: Wiefermann Julia , Kaminski Jeremy M. , Pankert Elisabeth , Hertel Dirk , Meerholz Klaus , Marian Christel M. , Müller Thomas J. J. 
Published: December 2022

AbstractIn this work, we perform an in‐depth investigation of the optoelectronic properties of a blue emitter (4’’‐(diphenylamino)‐2’’‐methyl‐[1,1’:4’,1’’‐terphenyl]‐4‐carbonitrile), which was reported earlier. Lippert–Mataga analysis of the emission spectra obtained in solvents of varying polarity reveal charge transfer (CT) contributions to the first singlet excited state, S1. Multi‐reference quantum chemical calculations clearly show a balanced local excitation (LE) and CT character of the S1state and suggests the presence of a LE triplet state, T2, in its energetic vicinity. Finally, organic light emitting diodes (OLED) revealed blue emission at 451 nm and an external quantum efficiency (EQE) of 2 %, corresponding to an internal quantum efficiency (IQE) of circa 10 %.
Optimizing Ramadan fasting: A randomised controlled trial for people with type 2 diabetes during Ramadan applying the principles of the ADA/EASD consensus
Authors: Ibrahim Mahmoud , Barker Mary Moffett , Ahmad Ehtasham , Ahmed Asma , Annabi Firas A. , Ba‐Essa Ebtesam M. , Davies Melanie J. , Houeiss Pamela , Iraqi Hinde , Masood Shabeen Naz , Mimouni‐Zerguini Safia , Shaikh Shehla , Tantawi Hyam , Tuomilehto Jaakko 
Published: December 2022

AbstractBackgroundFasting during the holy month of Ramadan is one of the five pillars of Islam. Fasting is not meant to create excessive hardship on the Muslim individual according to religious tenets. It is important that health professionals are aware of potential risks associated with fasting during the month of Ramadan (mainly hypoglycemia and hyperglycemia).AimsTo explore the impact of applying the principles of our 2020 recommendations for the management of type 2 diabetes (T2D) during the month of Ramadan.MethodsA multinational randomized controlled trial (RCT) was conducted in five Muslim majority countries. Six hundred and sixty participants were deemed eligible for the study; however, 23% declined to participate later for various reasons. In total, 506 participants were enroled and were equally randomized to the intervention or the control group. At the end of the study, data from 231 participants in the intervention group and 221 participants from the control group were collected after 12.6% and 8.7% were, respectively, lost to follow‐up. Participants were randomized to receive a Ramadan‐focussed education with treatment for diabetes adjusted as per our 2020 recommendation update compared with the local usual care (control group). Results are presented using mean, standard deviation, odds ratio (OR), and percentages.ResultsAt the end of the study, the number of hypoglycemic episodes in the intervention group was less than in participants who received usual care. The intervention group had significantly lower severe hypoglycemia compared to the control group with an OR of 0.2 [0.1–0.8]. Compared to baseline, both groups had a significant reduction in glycated haemoglobin (HbA1c), but the improvements were significantly greater in the intervention group. Whilst body weight reduced and high‐density lipoprotein cholesterol increased with the intervention, these changes were not significantly different from usual care.ConclusionsA pre‐Ramadan assessment of people with T2D coupled with pre‐Ramadan education and an adjustment of glucose‐lowering treatment as per our updated 2020 recommendations can prevent acute complications and allow a safer fast for people with T2D. We have shown that such an approach reduces the risk of developing severe hypoglycemia and improves the metabolic outcomes in people with T2D.