bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemotherapy‐Induced Senescence Reprogramming Promotes Nasopharyngeal Carcinoma Metastasis by circRNA‐Mediated PKR Activation
Authors: Li Qian , Zhao Yu‐Heng , Xu Cheng , Liang Ye‐Lin , Zhao Yin , He Qing‐Mei , Li Jun‐Yan , Chen Kai‐Lin , Qiao Han , Liu Na , Ma Jun , Chen Lei , Li Ying‐Qin 
Published: January 2023

AbstractSenescence is associated with tumor metastasis and chemotherapy resistance, yet the mechanisms remain elusive. Here, it is identified that nasopharyngeal carcinoma (NPC) patients who developed distant metastasis are characterized by senescence phenotypes, in which circWDR37 is a key regulator. CircWDR37 deficiency limits cisplatin or gemcitabine‐induced senescent NPC cells from proliferation, migration, and invasion. Mechanistically, circWDR37 binds to and dimerizes double‐stranded RNA‐activated protein kinase R (PKR) to initiate PKR autophosphorylation and activation. Independent of its kinase activity, phosphorylated PKR induces I‐kappaB kinase beta (IKKβ) phosphorylation, binds to and releases RELA from NF‐κB inhibitor alpha (IκBα) to trigger nuclear factor kappa B (NF‐κB) activation, thereby stimulating cyclin D1 (CCND1) and senescence‐associated secretory phenotype component gene transcription in a circWDR37‐dependent manner. Low circWDR37 levels correlate with chemotherapy response and favorable survival in NPC patients treated with gemcitabine or cisplatin induction chemotherapy. This study uncovers a new mechanism of circWDR37 activated PKR in senescence‐driven metastasis and provides appealing therapeutic targets in NPC.
Nanoparticle Exsolution from Nanoporous Perovskites for Highly Active and Stable Catalysts
Authors: Rudolph Benjamin , Tsiotsias Anastasios I. , Ehrhardt Benedikt , Dolcet Paolo , Gross Silvia , Haas Sylvio , Charisou Nikolaos D. , Goula Maria A. , Mascotto Simone 
Published: January 2023

AbstractNanoporosity is clearly beneficial for the performance of heterogeneous catalysts. Although exsolution is a modern method to design innovative catalysts, thus far it is predominantly studied for sintered matrices. A quantitative description of the exsolution of Ni nanoparticles from nanoporous perovskite oxides and their effective application in the biogas dry reforming is here presented. The exsolution process is studied between 500 and 900 °C in nanoporous and sintered La0.52Sr0.28Ti0.94Ni0.06O3±δ. Using temperature‐programmed reduction (TPR) and X‐ray absorption spectroscopy (XAS), it is shown that the faster and larger oxygen release in the nanoporous material is responsible for twice as high Ni reduction than in the sintered system. For the nanoporous material, the nanoparticle formation mechanism, studied by in situ TEM and small‐angle X‐ray scattering (SAXS), follows the classical nucleation theory, while on sintered systems also small endogenous nanoparticles form despite the low Ni concentration. Biogas dry reforming tests demonstrate that nanoporous exsolved catalysts are up to 18 times more active than sintered ones with 90% of CO2conversion at 800 °C. Time‐on‐stream tests exhibit superior long‐term stability (only 3% activity loss in 8 h) and full regenerability (over three cycles) of the nanoporous exsolved materials in comparison to a commercial Ni/Al2O3catalyst.
High‐Valence‐Manganese Driven Strong Anchoring of Iridium Species for Robust Acidic Water Oxidation
Authors: Weng Yuxiao , Wang Keyu , Li Shiyi , Wang Yixing , Lei Linfeng , Zhuang Linzhou , Xu Zhi 
Published: January 2023

AbstractDesigning an efficient and durable electrocatalyst for the sluggish anodic oxygen evolution reaction (OER) has been the primary goal of using proton exchange membrane electrolyzer owing to the highly acidic and oxidative environment at the anode. In this work, it is reported that high‐valence manganese drives the strong anchoring of the Ir species on the manganese dioxide (MnO2) matrix via the formation of an Mn–O–Ir coordination structure through a hydrothermal‐redox reaction. The iridium (Ir)‐atom‐array array is firmly anchored on the Mn–O–Ir coordination structure, endowing the catalyst with excellent OER activity and stability in an acidic environment. Ir‐MnO2(160)‐CC shows an ultralow overpotential of 181 mV at j = 10 mA cm−2 and maintains long‐term stability of 180 h in acidic media with negligible decay, superior to most reported electrocatalysts. In contrast, when reacting with low‐valence MnO2, Ir species tend to aggregate into IrOx nanoparticles, leading to poor OER stability. Density functional theory (DFT) calculations further reveal that the formation of the Mn–O–Ir coordination structure can optimize the adsorption strength of *OOH intermediates, thus boosting the acidic OER activity and stability.
Achieving Both Ultrahigh Electrical Conductivity and Mechanical Modulus of Carbon Films: Templating‐Coalescing Behavior of Single‐Walled Carbon Nanotube in Polyacrylonitrile
Authors: Lee Jung‐Eun , Kim Jung Hoon , Han Joong Tark , Chae Han Gi , Eom Youngho 
Published: January 2023

AbstractPromoting the feasibility of carbon films as electrode applications requires sufficient performances in view of both electrical and mechanical properties. Herein, carbon films with ultrahigh electrical conductivity and mechanical modulus are prepared by high temperature carbonization of polyacrylonitrile (PAN)/single‐walled carbon nanotube (SWNT) nanocomposites. Achieving both performances is ascribed to remarkable graphitic crystallinity, resulting from the sequential templating–coalescing behavior of concentrated SWNT bundles (B‐CNTs). While well‐dispersed SWNTs (WD‐CNTs) facilitate radial templating according to their tubular geometry, flattened B‐CNTs sandwiched between carbonized PAN matrices induce vertical templating, where the former and latter produce concentric and planar crystallizations of the graphitic structure, respectively. After carbonization at 2500 °C with the remaining WD‐CNTs as microstructural defects, the flattened B‐CNTs coalesce into graphitic crystals by zipping the surrounding matrix, resulting in high crystallinity with the crystal thicknesses of 27.4 and 39.4 nm for the (002) and (10) planes, respectively. For comparison, the graphene oxide (GO) containing carbon films produce a less‐ordered graphitic phase owing to irregular templating, despite the geometrical consistency. Consequently, PAN/B‐CNT carbon films exhibit exceptional electrical conductivity (40.7 × 104 S m−1) and mechanical modulus (38.2 ± 6.4 GPa). Thus, controlling the templating−coalescing behavior of SWNTs is the key for improving final performances of carbon films.
Low‐Voltage Driven Ionic Polymer‐Metal Composite Actuators: Structures, Materials, and Applications
Authors: Zhang Hao , Lin Zhaohua , Hu Yong , Ma Suqian , Liang Yunhong , Ren Lei , Ren Luquan 
Published: January 2023

AbstractWith the characteristics of low driving voltage, light weight, and flexibility, ionic polymer‐metal composites (IPMCs) have attracted much attention as excellent candidates for artificial muscle materials in the fields of biomedical devices, flexible robots, and microelectromechanical systems. Under small voltage excitation, ions inside the IPMC proton exchange membrane migrate directionally, leading to differences in the expansion rate of the cathode and the anode, which in turn deform. This behavior is caused by the synergistic action of a three‐layer structure consisting of an external electrode layer and an internal proton exchange membrane, but the electrode layer is more dominant in this process due to the migration and storage of ions. The exploration of modifications and alternatives for proton exchange membranes and recent advances in the fabrication and characterization of conductive materials, especially carbon‐based materials and conductive polymers, have contributed significantly to the development of IPMCs. This paper reviews the progress in the application of proton exchange membranes and electrode materials for IPMCs, discusses various processes currently applied to IPMCs preparation, and introduces various promising applications of cutting‐edge IPMCs with high performance to provide new ideas and approaches for the research of new generation of low‐voltage ionic soft actuators.
Fully‐Conjugated Covalent Organic Frameworks with Two Metal Sites for Oxygen Electrocatalysis and Zn–Air Battery
Authors: Li Jiawen , Liu Peng , Yan Jianyue , Huang Hao , Song Wenbo 
Published: January 2023

AbstractCovalent organic frameworks (COFs) are a promising alternative toward catalysis, due to the unique framework structure and the excellent chemical stability. However, the scarcity of unsaturated metal sites and the low conductivity have constrained the advancement of these materials for catalysis of electrochemical reactions. Exploring next‐generation conductive metal–covalent organic frameworks (M‐COFs) with extra metal active sites is crucial for improving their catalytic activity. Herein, a novel fully‐conjugated M‐COFs (Co‐PorBpy‐Co) with two types of metal sites is proposed and achieved by solvothermal method in the presence of carbon nanotube (CNT). The electrocatalyst constructed by the Co‐PorBpy‐Co exhibits excellent oxygen reduction reaction (ORR) activity (E1/2 = 0.84 V vs RHE, n = 3.86), superior to most COFs‐based catalysts. Theoretical result shows the CoN2 sites are extremely active for ORR, and Co‐PorBpy‐Co exhibits excellent conductivity for electron transfer. The Zn–air battery constructed by Co‐PorBpy‐Co/CNT manifests excellent power density (159.4 mW cm−2) and great cycling stability, surpassing that of 20 wt% Pt/C catalyst. This work not only proposes a novel design concept for electrocatalysts, but establishes a mechanism platform for single‐metal atom electrocatalysis and synergistic effect.
One‐Step Soaking Strategy toward Anti‐Swelling Hydrogels with a Stiff “Armor”
Authors: Dou Xueyu , Wang Hufei , Yang Fei , Shen Hong , Wang Xing , Wu Decheng 
Published: January 2023

AbstractDouble‐network (DN) hydrogels consisting of noncovalent interacting networks are highly desired due to their well‐controlled compositions and environmental friendliness, but the low water resistance always impairs their mechanical strength. Here, an anti‐swelling hydrogel possessing the core/shell architecture through rational regulation of multiple weak noncovalent interactions is prepared. A composite hydrogel consists of chitosan (CS) and poly(N‐acryloyl 2‐glycine) (PACG), readily forming the shell‐structured DN hydrogel after soaking in a FeCl3 solution because of in situ formation of chain entanglements, hydrogen bonds, and ionic coordination. The produced DN hydrogels exhibit excellent anti‐swelling behaviors and mechanical durability for over half a year, even in some strict situations. Taking the merits of noncovalent bonds in adjustability and reversibility, the swelling property of these hydrogels can be easily customized through control of the ion species and concentrations. A dynamically reversible transition from super‐swelling to anti‐swelling is realized by breaking up and rebuilding the metal‐coordination complexes. This facile but efficient strategy of turning the noncovalent interactions and consequently the mechanics and anti‐swelling properties is imperative to achieve the rational design of high‐performance hydrogels with specific usage requirements and expand their applicability to a higher stage.
All‐Printed Flexible Hygro‐Thermoelectric Paper Generator
Authors: Shen Haoyu , Xu Ke , Duan Yulong , Wu Peilin , Qian Zhiyun , Chen Yonghao , Luo Yao , Liu Chaocheng , Li Yang , Cui Jiedong , Liu Detao 
Published: January 2023

AbstractThe conversion of ubiquitous hygrothermal resources into renewable energy offers significant potential for cable‐free, self‐powered systems that can operate worldwide without regard to climatic or geographic limitations. Here, an all‐printed flexible hygro‐thermoelectric paper generator is demonstrated that uses bifunctional mobile ions and electrons to make the moist‐diffusion effect, the Soret effect, and the Seebeck effect work synergistically. In the ordinary hygrothermal settings, it generates an unconventional hygro‐thermoelectric output pattern and shows almost a dozen‐fold increase in positive hygro‐thermopower of 26.70 mV K−1 and also another negative hygro‐thermopower of −15.71 mV K−1 compared to pure thermopower. A single paper generator can produce a giant 680 mV displaying typical cyclic sinusoidal waveform characters with volt‐sized amplitudes. The ion‐electron conductive ink is easily printable and consists primarily of a Bi2Te3/PEDOT:PSS thermoelectric matrix modulated with a hygroscopic glycerol that releases ion charges for moist‐diffusion effect and Soret effect, as well as electron charges for Seebeck effect. The emerged hygro‐thermoelectric harvesting strategy from surrounding hygrothermal resources offers a revolutionary approach to the next generation of hybrid energy with cost‐efficiency, flexibility, and sustainability, and also enables large‐scale roll‐to‐roll production.
An Ultrasensitive Sandwiched Heterostructure Planar Photodetector with Gradient Quasi‐2D Perovskite
Authors: Pan Yiyi , Wang Haoliang , Wang Yaxin , Wang Yanyan , Li Xiaoguo , Liu Yiting , Deng Liangliang , Liu Kai , Hu Tianxiang , Liu Fengcai , Shi Zejiao , Li Chongyuan , Wang Jiao , Yu Anran , Zhang Xiaolei , Zhan Yiqiang 
Published: January 2023

Abstract2D Ruddlesden–Popper perovskites have attracted increasing attention for their outstanding optoelectronic properties and improved stability compared to the 3D counterparts. The unique nature of the crystal growth orientations and the uneven distribution in the 2D perovskites provide a great opportunity to construct a promising lateral photodetector device that has not been fully uncovered. Here, by improving the random orientation to the vertical orientation of the film in the lateral device structure, the dark current is expected to be significantly suppressed in the photodetector. Accompanied by the gradient phase distribution, a p‐type conductive channel at the bottom and another electron collection layer on the top are applied to achieve a high on/off ratio. Overall, the resultant photodetector realizes a low dark current of 10−10 A and exhibits impressive photodetection performance, including a high responsivity of 10.10 A W−1, a notable detectivity of 6.83 × 1012 Jones, and fast response speeds (14 ms/31 ms).
Sinter‐Resistant Nickel Catalyst for Lignin Hydrogenolysis Achieved by Liquid Phase Atomic Layer Deposition of Alumina
Authors: Talebkeikhah Farzaneh , Sun Songlan , Luterbacher Jeremy S. 
Published: January 2023

AbstractLignin hydrogenolysis is a key step in the sustainable production of renewable bio‐based chemicals and fuels. Heterogeneous metal catalysts have led to high yields but they rapidly deactivate, notably due to nanoparticle sintering and carbonaceous deposit formation. While these deposits can be removed by regeneration, sintering is irreversible and a significant barrier to commercialization. Here, simple liquid phase atomic layer deposition is used to deposit an alumina layer to protect nickel particles from sintering. In the gas phase, it is proved that alumina can prevent sintering during reduction up to 600 °C. This catalyst for hydrogenolysis of extracted lignin in batch and continuous operation is used. In batch, the overcoated catalyst maintains high monomer yields with little sintering over four cycles of reuse while the yield obtained with the catalyst without an overcoat reduces to half and severe sintering occurs. In a continuous flow reactor, deactivation rates are three times lower for the catalyst with the alumina overcoat. Microscopy images confirm that the alumina overcoat largely preserves nickel particle sizes after ten days of operation. The results demonstrate that catalyst overcoating with metal oxides substantially slows irreversible deactivation during lignin hydrogenolysis, which could facilitate the development of continuous lignin upgrading.
Ordered and Isolated Pd Sites Endow Antiperovskite‐Type PdFe3N with High CO‐Tolerance for Formic Acid Electrooxidation
Authors: Liang Lecheng , Li Meng , Zhang Bentian , Liang Jinhui , Zeng Binwen , Wang Liming , Tang Yawen , Fu Gengtao , Cui Zhiming 
Published: January 2023

AbstractThe fundamental understanding and precise control of catalytic sites are challenging yet essential to explore advanced electrocatalysts for the formic acid oxidation reaction (FAOR). Herein, this work demonstrates a new and promising catalyst prototype of antiperovskite‐type PdFe3N which possesses ordered and isolated Pd sites. The as‐synthesized PdFe3N/N‐rGO exhibits significant enhancement in catalytic activity, robust stability, and Fe anti‐dissolution properties when compared with PdFe3/rGO and Pd/C. Density functional theory (DFT) calculations reveal that isolated and ordered Pd sites are beneficial for high formate coverage and thus suppressing CO formation/poisoning. Moreover, the strong Fe–N covalent bonds improve the vacancy formation energy of Fe, which ensures superior Fe anti‐dissolution properties. Beyond offering a promising candidate for catalyzing FAOR, these findings provide deeper insights into the structure of CO tolerance relationships and benefit the theory‐guided design of highly efficient catalysts.
Gene‐targeted therapies: Towards equitable development, diagnosis, and access
Authors: Gaviglio Amy M. , Skinner Mark W. , Lou Lily J. , Finkel Richard S. , Augustine Erika F. , Goldenberg Aaron J. 
Published: January 2023

AbstractGenomic and gene‐targeted therapies hold great promise in addressing the global issue of rare diseases. To achieve this promise, however, it is critical the twin goals of equity in access to testing and diagnosis, and equity in access to therapy be considered early in the life cycle of development and implementation. Rare disease researchers and clinicians must simultaneously recognize the life‐altering potential of early diagnosis and administration of gene‐targeted therapeutics while acknowledging that not everyone who experiences a rare disease and needs these therapies will be able to afford or access them. Achieving equity in the development of and access to gene‐targeted therapies will not only require innovations in research, clinical, regulatory, and reimbursement frameworks, but will also necessitate increased attention to the ethical, legal, and social implications when establishing research paradigms and the translation of research results into novel interventions for rare genetic diseases. This article highlights and discusses the growing importance and recognition of health equity across the spectrum of rare disease research and care delivery.
Effects of food availability and climate on the activity budget of Shortridge's langur (Trachypithecus shortridgei) in the Drung Valley, Gaoligong Mountains, China
Authors: Zhang Jia‐Yang , Li Ying‐Chun , Yang Yin , Garber Paul A. , Han Ke‐Guo , Huang Zhi‐Pang , Cui Liang‐Wei , Xiao Wen 
Published: January 2023

AbstractFood availability and climate represent environmental factors that affect species' social behavior, ranging patterns, diet, and activity budget. From August 2012 to September 2013, we examined the effects of seasonal changes in food availability, temperature, and rainfall on the diet and behavioral ecology of Shortridge's langur (Trachypithecus shortridgei) an Endangered primate species inhabiting moist evergreen broadleaf forests in the Eastern Himalayas. Our field site represents the northernmost latitudinal distribution of this species. Data were collected using scan sampling at 10 min intervals, and analyzed based on generalized linear models. The results indicate that the langurs experienced two feeding peaks (9:00 and 17:00) and two traveling peaks (10:00 and 19:00) during each day. Periods of rest, mainly occurred between 10:00 and 13:00, and overnight. Feeding accounted for 38.5% of the daily activity budget, followed by resting (35%), traveling (24.5%), and socializing (2%). During periods when young leaves were most available, the langurs increased feeding time on young leaves (35% vs. 4%). During periods of maximum fruit availability, the langurs decreased total time spent feeding (36.6% vs. 40.4%), devoted more time to traveling (28.1% vs. 21%), and increased time spent consuming fruit (49.1% vs. 11.8%). During the winter, the langurs increased their consumption of mature leaves (44.5%) and reduced time spent traveling (20.2% vs. 25.4%). Overall, time spent resting was greatest in the spring (47.5%), time spent feeding was greatest during the summer (51.1%), and time spent in traveling was greatest in the autumn (33.2%). The frequency of social interactions remained relatively constant throughout the year. Foraging effort was greatest in the summer, when fruits dominated the diet. Like other species of temperate langurs, T. shortridgei devoted less time to resting, more time to feeding, and was characterized by a greater year‐round foraging effort than tropical/subtropical langurs.
Markers of olfactory dysfunction and progression to dementia: A 12‐year population‐based study
Authors: Laukka Erika J , Ekström Ingrid , Larsson Maria , Grande Giulia , Fratiglioni Laura , Rizzuto Debora 
Published: January 2023

AbstractIntroductionWe evaluated markers of olfactory dysfunction (OD) for estimating hazard of dementia in older adults.MethodsMild (hyposmia) and severe (anosmia) OD was classified in a population‐based study of dementia‐free persons (SNAC‐K; n = 2473; mean age = 70 years) using the Sniffin sticks odor identification task. Combined variables were created for objective and subjective OD and for OD and APOE status. Hazard of dementia across 12 years was estimated with Cox regression.ResultsOD was associated with increased hazard of dementia (2.01; 95% confidence interval [CI] 1.60‐2.52), with the strongest association for anosmia (2.92; 95% CI 2.14‐3.98). Results remained consistent after adjusting for potential confounders and across age and sex subgroups. APOE ε4 carriers with anosmia had the highest hazard of dementia (ε4: 6.95; 95% CI 4.16‐11.62; ε4/ε4: 19.84; 95% CI 6.17‐63.78).DiscussionOD is associated with increased risk of dementia, especially severe impairment in combination with genetic risk of Alzheimer's disease.
Simultaneous Stabilization of Lithium Anode and Cathode using Hyperconjugative Electrolytes for High‐voltage Lithium Metal Batteries
Authors: Zhang Haikuo , Li Ruhong , Chen Long , Fan Yingzhu , Zhang Hao , Zhang Ruixin , Zheng Lei , Zhang Junbo , Ding Shouhong , Wu Yongjian , Ma Baochen , Zhang Shuoqing , Deng Tao , Chen Lixin , Shen Yanbin , Fan Xiulin 
Published: January 2023

AbstractAlthough great progress has been made in new electrolytes for lithium metal batteries (LMBs), the intrinsic relationship between electrolyte composition and cell performance remains unclear due to the lack of valid quantization method. Here, we proposed the concept of negative center of electrostatic potential (NCESP) and Mayer bond order (MBO) to describe solvent capability, which highly relate to solvation structure and oxidation potential, respectively. Based on established principles, the selected electrolyte with 1.7 M LiFSI in methoxytrimethylsilane (MOTMS)/ (trifluoromethyl)trimethylsilane (TFMTMS) shows unique hyperconjugation nature to stabilize both Li anode and high‐voltage cathode. The 4.6 V 30 μm Li||4.5 mAh cm−2 lithium cobalt oxide (LCO) (low N/P ratio of 1.3) cell with our electrolyte shows stable cycling with 91 % capacity retention over 200 cycles. The bottom‐up design concept of electrolyte opens up a general strategy for advancing high‐voltage LMBs.