bluuebunny/crossref_metadata_2025_split huggingface dataset:
ON THE PROSPECTS OF DEVELOPMENT OF THE UKRAINIAN ACADEMY OF ARCHITECTURE
Authors: Shulyk Vasyl 
Published: August 2023

The term "academy" originated in Ancient Greece, nowadays, it has preserved its main features acquired in the course of historical development. The phenomenon embodies the process of acquiring, preserving and transmitting knowledge, and includes the personalities and institutions that do so.
Academic culture is a broader concept for scientific culture. Also, the academic community is a broader notion for the scientific community. Accordingly, the Ukrainian Academy of Architecture is an academic society, not strictly scientific, because it includes architecture as a synthesizing or unifying form of the art of shaping the living environment of the population.
Joint activities of the Ukrainian Academy of Architecture and the National Union of Architects of Ukraine can bring tangible results, facilitate contacts with government agencies responsible for the development of architecture.
The development of the creative community in modern conditions necessitates the use of the main provisions of strategic and creative management. It allows to form a positive image of creative organization, to increase competitiveness, to use limited resources more effectively, to increase profit and to formulate a clear development strategy.
On the whole, proceeding from the above-mentioned, the main directions of the Ukrainian Academy of Architecture's activity during the nearest period must be the following: 1) acquiring (scientific research) knowledge; 2) preserving and passing on knowledge; 3) practical developments in architecture and town-planning; 4) promotion and publishing activities 5) maintenance of close cooperation with the Union of Architects of Ukraine, Academy of Construction of Ukraine, establishment of mutually beneficial cooperation with governmental bodies responsible for the development of architecture and urban planning.
Parent Training dan Manajemen Stress pada Kesehatan Jiwa Caregiver yang Merawat Anak Pekerja Migran
Authors: Wicaksono Kurniawan Erman , Kurniyanti Mizam Ari 
Published: August 2023

Abstrak
Permasalahan psikologis anak yang ditinggal orangtuanya menjadi pekerja migran Indonesia yaitu masalah psikososial hingga masalah perkembangan dan pertumbuhan anak. Tujuan penelitian ini adalah menganalisis parent training dan manajemen stress terhadap kesehatan jiwa caregiver merawat anak yang ditinggal orangtua pekerja migran Indonesia. Metode penelitian yang digunakan adalah quasi experiment yang terbagi dua kelompok yaitu kelompok kontrol dan kelompok eksperimen dengan pemberian intervensi parent training dan manajemen stress. Jumlah responden 100 caregiver yang tersebar di wilayah kerja Puskesmas Pamotan dengan kriteria caregiver mengasuh anak yang ditinggal orangtua menjadi pekerja migran Indonesia, caregiver sudah merawat anak pekerja tiga tahun, dan caregiver mengalami masalah kesehatan. Teknik sampling yang digunakan secara non probability sampling dengan teknik purposive sampling. Alat ukur yang digunakan mengukur kesehatan jiwa caregiver yang mengasuh anak ditinggal orang tua menjadi pekerja migran Indonesia adalah parental stress scale (PSS). Data hasil penelitian diuji menggunakan uji t berpasangan untuk mengetahui perbedaan rerata skor kesehatan jiwa caregiver pada kelompok intervensi dan kelompok kontrol. Data hasil uji t berpasangan menunjukkan adanya perbedaan bermakna skor kesehatan jiwa caregiver antara kelompok intervensi dan kontrol dengan nilai p = 0,000 (p < 0,05). Parent training dan manajemen stress memiliki pengaruh terhadap kesehatan jiwa caregiver dalam merawat anak pekerja migran.
Kata Kunci: parent training, manajemen stress, caregiver, migran
Abstract
The psychological problems of children whose parents have become Indonesian migrant workers range from psychosocial issues to problems of child development and growth. The purpose of this study was to analyze parent training and stress management on the mental health of caregivers caring for children left behind by the parents of Indonesian migrant workers. The research method used a quasi-experiment into two groups, namely the control and the Intervention Group By Providing Parent Training Interventions And Stress Management. Respondents Of This Study was 100 caregivers with the criteria of caregivers taking care of children left by their parents to become Indonesian migrant workers, have cared for three-year-old working children, and experiencing health problems. The sampling technique used non-probability sampling with a purposive sampling technique. The measuring tool used to the mental health of caregivers is the parental stress scale (PSS). Result of this study used the paired t-test showed that was a significant difference in caregiver mental health scores between the intervention and control groups with p=0.000 (p<0.05). Parent training and stress management have an influence on the mental health of caregivers in caring for children of migrant workers.
Keywords: parent training, stress management, caregivers, migrants
Detyrosinated microtubule arrays drive myofibrillar malformations in mdx muscle fibers
Authors: Harriot Anicca D. , Altair Morris Tessa , Vanegas Camilo , Kallenbach Jacob , Pinto Kaylie , Joca Humberto C. , Moutin Marie-Jo , Shi Guoli , Ursitti Jeanine A. , Grosberg Anna , Ward Christopher W. 
Published: August 2023

Altered myofibrillar structure is a consequence of dystrophic pathology that impairs skeletal muscle contractile function and increases susceptibility to contraction injury. In murine Duchenne muscular dystrophy (mdx), myofibrillar alterations are abundant in advanced pathology (&gt;4 months), an age where we formerly established densified microtubule (MT) arrays enriched in detyrosinated (deTyr) tubulin as negative disease modifiers impacting cell mechanics and mechanotransduction. Given the essential role of deTyr-enriched MT arrays in myofibrillar growth, maintenance, and repair, we examined the increased abundance of these arrays as a potential mechanism for these myofibrillar alterations. Here we find an increase in deTyr-tubulin as an early event in dystrophic pathology (4 weeks) with no evidence myofibrillar alterations. At 16 weeks, we show deTyr-enriched MT arrays significantly densified and co-localized to areas of myofibrillar malformation. Profiling the enzyme complexes responsible for deTyr-tubulin, we identify vasohibin 2 (VASH2) and small vasohibin binding protein (SVBP) significantly elevated in the mdx muscle at 4 weeks. Using the genetic increase in VASH2/SVBP expression in 4 weeks wild-type mice we find densified deTyr-enriched MT arrays that co-segregate with myofibrillar malformations similar to those in the 16 weeks mdx. Given that no changes in sarcomere organization were identified in fibers expressing sfGFP as a control, we conclude that disease-dependent densification of deTyr-enriched MT arrays underscores the altered myofibrillar structure in dystrophic skeletal muscle fibers.
A ternary eutectic solvent for cellulose nanocrystal production: exploring the recyclability and pre-pilot scale-up
Authors: Mariño Mayra A. , Paredes Maria G. , Martinez Natalia , Millan Daniela , Tapia Ricardo A. , Ruiz Domingo , Isaacs Mauricio , Pavez Paulina 
Published: August 2023

Deep eutectic solvents (DES) formed using choline chloride (ChCl), p-toluenesulfonic acid (pTSA) of stoichiometry ChCl: pTSA (1:1) and (1:2), and its ternary eutectic mixtures with phosphoric acid (PA) 85% as an additive (ChCl: pTSA: PA) were evaluated for cellulose nanocrystal (CNC) isolation. Initially, the hydrolytic efficiency to produce CNC of each DES was compared before and after adding phosphoric acid by Hammett acidity parameters and the Gutmann acceptor number. Moreover, different DES molar ratios and reaction time were studied at 80°C for CNC optimization. The nanomaterial characteristics were analyzed by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The ternary eutectic mixture ChCl: pTSA: PA molar ratio (1:1:1.35) was chosen as a suitable recyclable ternary system at the laboratory scale. A CNC yield of about 80% was obtained from the hydrolysis of commercial cellulose in five cycles of recovery, but it dropped to 35% in pre-pilot scaling. However, no variation in the average size of the resulting CNC was observed (132 ± 50 nm x 23 ± 4 nm), which presented high thermal stability (Tmax 362°C) and high crystallinity of about 80% after 3 h of reaction time.
Formal education vs. informal education in the Roma community—a silent confrontation where nobody wins
Authors: Herțanu Margareta , Soponaru Camelia , Păduraru Ancuța E. 
Published: August 2023

ObjectivesOur main aim was to identify the advantages and disadvantages that the Roma relate to formal education vs. informal education, a discrepancy in the balance between the two can enrich the explanations regarding their low level of schooling—which hinders their social inclusion.MethodThere were 28 participants of Roma ethnicity, aged between 19 and 52 years old, who took part in the study: 15 were married, 13 were single, all of them school graduates. The design of the study is a qualitative one and the data was collected by means of three focus groups, based on a semi-structured interview. The data was analysed by using the method of content analysis.ResultsIn addition to the disadvantages related to institutional and economic factors, the Roma encounter in schools that belong to the cultural majority difficulties related to language and a lack of elements belonging to their culture. While they get used to the culture of the majority, they feel that they lose their own identity and that they are silently excluded from their community.ConclusionFormal education is seen as a way of personal development and as a path to an advantageous job, a door of access to the majority culture. However, informal education seems to win all the time, as a result of the family sovereignty and the fact that it is the central factor in the transmission and preservation of the Roma culture.
Influencing of serum inflammatory factors on IVF/ICSI outcomes among PCOS patients with different BMI
Authors: He Yilei , Li Rong , Yin Jingwen , Yang Zi , Wang Yuanyuan , Chen Lixue , Yang Shuo , Qiao Jie 
Published: August 2023

IntroductionOverweight and obese are important factors leading to the occurrence of long-term complications in women with polycystic ovary syndrome (PCOS). There has been controversy over whether dissatisfaction with pregnancy outcomes in PCOS patients is influenced by chronic inflammatory status or obesity. This retrospective study analyzed the levels of inflammatory factors in PCOS patients with different body mass index (BMI) groups and effective predictors of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) pregnancy outcomes.MethodsThere were 273 women with PCOS diagnosed who completed serum inflammatory factors test between January 2017 and June 2022 were selected. The data of 7,649 infertility PCOS patients who received their first IVF/ICSI treatment in the Reproductive Center of Peking University Third Hospital during the period of the study were collected. Finally, 92 PCOS patients were included in the high BMI group, while 97 patients were included in the normal BMI group. Baseline characteristics were collected and the pregnancy outcomes were compared among the two groups. Then, serum inflammatory factors’ effect on IVF/ICSI pregnancy outcomes were analyzed with age, anti-Mullerian Hormone (AMH) and BMI adjusted.ResultsPCOS patients in the high BMI group significantly had a lower number of oocytes retrieved and good quality embryos. The high BMI group PCOS patients had higher levels of IL-6 and lower cumulative clinical pregnancy and live birth rates. The level of GM-CSF was higher in the first cycle transfer and cumulative miscarriage group. High TNF-α was negatively correlated with the first transfer cycle and cumulative clinical pregnancy rates after age, AMH and high BMI adjusted. In addition, the cumulative live birth rate was negatively correlated with high IL-6, but the first cycle transfer and cumulative live birth rates were positively correlated with high IL-1β.DiscussionFor PCOS patients, in addition to BMI, attention should also be paid to inflammatory indicators. High levels of TNF-α and IL-6 were negatively correlated with pregnancy outcomes, but high IL-1β was positively correlated with live birth rates among PCOS patients. The level of GM-CSF was higher in miscarriage PCOS patients.
Retinal vein changes in patients with high-risk proliferative diabetic retinopathy treated with conbercept and panretinal photocoagulation co-therapy: a cohort study
Authors: Si Mingwei , Tao Yuan , Zhang Ziniu , Zhao Hui , Cui Wenxuan , Yang Mengyao , Wang Hong 
Published: August 2023

ObjectiveThis study aimed to observe and compare retinal vein diameter changes and other essential indicators in patients with high-risk proliferative diabetic retinopathy (PDR) treated with intravitreal injection of conbercept (IVC) combined with panretinal photocoagulation (PRP) versus PRP monotherapy.MethodsA retrospective analysis was conducted on data from patients with high-risk PDR who received specific treatment and were followed up for 24 months. Among 82 patients with high-risk PDR, 50 eyes received PRP combined with IVC, whereas 32 eyes received PRP alone. During the 24-month follow-up period, changes in best-corrected visual acuity (BCVA), central foveal thickness (CFT), retinal vein diameter, number of microaneurysms (MA), neovascularization (NV) area, hard exudate (HE) area, size of the foveal avascular zone (FAZ), superficial capillary plexus (SCP) blood flow density, and adverse effects were recorded and compared between the two groups at baseline and at 6, 12, 18, and 24 months after treatment. The relationship between each observation index and vein diameter was also analyzed.ResultsDuring the 24-month follow up, significant improvements in the BCVA, CFT, retinal vein diameter, number of MAs, NV area, HE area, FAZ, and SCP were observed in the IVC+PRP group after treatment. The PRP group only showed significant reductions in NV and HE areas. The IVC+PRP group showed significant superiority over the PRP group in improving the vein diameter, number of MA, and HE area. However, no statistically significant difference in NV area reduction was found between the groups.ConclusionIn the treatment of high-risk PDR, IVC+PRP therapy has a significant advantage over PRP monotherapy. IVC+PRP therapy may reverse diabetes-induced retinal vein changes, restoring morphology and function.
The role of serum vitamin D in patients with normal ovarian reserve undergoing the first IVF/ICSI cycle
Authors: Luo Rong , Wang Jiahui , Yang Yu , Xu Cen , Yang Minyan , Zhu Dandan , Wang Jia , Zhang Ping , Ge Hongshan 
Published: August 2023

BackgroundThe debate over the impact of vitamin D in assisted reproduction continues. The purpose of our study was to assess embryo quality and pregnancy outcomes among groups with different levels of vitamin D after the first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycle in patients with normal ovarian reserve (NOR).MethodsPatients in this retrospective cohort study were divided into three groups: severe vitamin D deficiency group (25OH-D &lt; 10 ng/ml), vitamin D deficiency group (10 ng/ml ≤ 25OH-D &lt; 20 ng/ml), and non-vitamin D deficiency group (25OH-D ≥ 20 ng/ml). The primary outcome was clinical pregnancy, while the secondary outcomes were mature oocytes, oocyte fertilization, available cleavage embryos, available blastocysts, biochemical pregnancy, early abortion, and embryo implantation. A modified Poisson regression model and multiple linear regression analysis were conducted for the multivariate analysis.Results264 NOR patients undergoing the first IVF/ICSI cycles were included. For the primary outcome, there was no significant difference in clinical pregnancy between the severe vitamin D deficiency group and the other two groups (vitamin D deficiency group: adjusted RR = 1.026; 0.780 - 1.350; P = 0.854; non-vitamin D deficiency group: adjusted RR = 1.092; 0.743 - 1.605; P = 0.652). For all secondary outcomes, no significant differences were observed among the severe vitamin D deficiency, vitamin D deficiency, and non-vitamin D deficiency groups (P &gt; 0.05). Exploratory subgroup analyses concerning the season of embryo transfer, phase of embryo transferred, and endometrial thickness, as well as the sensitivity analysis using logistic regression models for the primary outcome, revealed comparable clinical pregnancy rates among the groups (P &gt; 0.05). Subgroup analysis concerning ovarian stimulation protocol indicated that in the subgroup of gonadotrophin-releasing hormone (GnRH) antagonist protocol, the clinical pregnancy rate of the non-vitamin D deficiency group was significantly higher than that of the other two groups (P &lt; 0.05).ConclusionSerum vitamin D level was not associated with embryo quality and pregnancy outcomes for patients with NOR. Further studies with greater sample sizes and a longer follow-up period are needed to elucidate the relationships between vitamin D levels and IVF outcomes.
Credit rating- and credit score-based carbon emission quota trading model of city dwellers
Authors: Tang Donglai , Li Qiang , Zhang Jie , Chen Yongdong , Liu Youbo , Song Weiping 
Published: August 2023

Introduction: The reduction of electricity-related carbon emissions by city dwellers (CDs) is important for China to achieve low-carbon development and sustainable energy transformation. Due to the lack of incentives for reduction, electricity-related carbon emissions from CDs are increasing year by year. To this end, this paper proposes an electricity-related carbon emission quota trading model that integrates a credit rating and credit score system, particularly for motivating CDs to actively participate in carbon emission reduction.Methods: With the history of electricity bill payment data, the density-based spatial clustering of applications with noise (DBSCAN) algorithm is used to cluster CDs, forming different clusters of CDs with different sensitivity levels to carbon emission quota prices. Thereafter, based on the total carbon emission quota and tiered electricity prices from the power company, incentive rules according to the classification result and credit scores of CDs are formulated. Under certain conditions, a leader–follower Stackelberg game between CDs and the power company is built to determine the base price of the carbon emission quota, and thereby, referring to the credit scores of CDs, floating carbon emission quota prices are offered to them in the final settlement.Results: The simulation results for an actual community in a city in China show that the proposed method can considerably reduce the carbon emissions.Discussion: The proposed credit rating and credit score system outperforms the asymmetric Nash negotiation method in terms of promoting carbon emission reduction.
The impact of immunocompromise on outcomes of COVID-19 in children and young people—a systematic review and meta-analysis
Authors: Greenan-Barrett James , Aston Samuel , Deakin Claire T. , Ciurtin Coziana 
Published: August 2023

BackgroundDespite children and young people (CYP) having a low risk for severe coronavirus disease 2019 (COVID-19) outcomes, there is still a degree of uncertainty related to their risk in the context of immunodeficiency or immunosuppression, primarily due to significant reporting bias in most studies, as CYP characteristically experience milder or asymptomatic COVID-19 infection and the severe outcomes tend to be overestimated.MethodsA comprehensive systematic review to identify globally relevant studies in immunosuppressed CYP and CYP in general population (defined as younger than 25 years of age) up to 31 October 2021 (to exclude vaccinated populations) was performed. Studies were included if they reported the two primary outcomes of our study, admission to intensive therapy unit (ITU) and mortality, while data on other outcomes, such as hospitalization and need for mechanical ventilation were also collected. A meta-analysis estimated the pooled proportion for each severe COVID-19 outcome, using the inverse variance method. Random effects models were used to account for interstudy heterogeneity.FindingsThe systematic review identified 30 eligible studies for each of the two populations investigated: immunosuppressed CYP (n = 793) and CYP in general population (n = 102,022). Our meta-analysis found higher estimated prevalence for hospitalization (46% vs. 16%), ITU admission (12% vs. 2%), mechanical ventilation (8% vs. 1%), and increased mortality due to severe COVID-19 infection (6.5% vs. 0.2%) in immunocompromised CYP compared with CYP in general population. This shows an overall trend for more severe outcomes of COVID-19 infection in immunocompromised CYP, similar to adult studies.InterpretationThis is the only up-to-date meta-analysis in immunocompromised CYP with high global relevance, which excluded reports from hospitalized cohorts alone and included 35% studies from low- and middle-income countries. Future research is required to characterize individual subgroups of immunocompromised patients, as well as impact of vaccination on severe COVID-19 outcomes.Systematic Review RegistrationPROSPERO identifier, CRD42021278598.
Identification and verification of diagnostic biomarkers in recurrent pregnancy loss via machine learning algorithm and WGCNA
Authors: Wei Changqiang , Wei Yiyun , Cheng Jinlian , Tan Xuemei , Zhou Zhuolin , Lin Shanshan , Pang Lihong 
Published: August 2023

BackgroundRecurrent pregnancy loss defined as the occurrence of two or more pregnancy losses before 20-24 weeks of gestation, is a prevalent and significant pathological condition that impacts human reproductive health. However, the underlying mechanism of RPL remains unclear. This study aimed to investigate the biomarkers and molecular mechanisms associated with RPL and explore novel treatment strategies for clinical applications.MethodsThe GEO database was utilized to retrieve the RPL gene expression profile GSE165004. This profile underwent differential expression analysis, WGCNA, functional enrichment, and subsequent analysis of RPL gene expression using LASSO regression, SVM-RFE, and RandomForest algorithms for hub gene screening. ANN model were constructed to assess the performance of hub genes in the dataset. The expression of hub genes in both the RPL and control group samples was validated using RT-qPCR. The immune cell infiltration level of RPL was assessed using CIBERSORT. Additionally, pan-cancer analysis was conducted using Sangerbox, and small-molecule drug screening was performed using CMap.ResultsA total of 352 DEGs were identified, including 198 up-regulated genes and 154 down-regulated genes. Enrichment analysis indicated that the DEGs were primarily associated with Fc gamma R-mediated phagocytosis, the Fc epsilon RI signaling pathway, and various metabolism-related pathways. The turquoise module, which showed the highest relevance to clinical symptoms based on WGCNA results, contained 104 DEGs. Three hub genes, WBP11, ACTR2, and NCSTN, were identified using machine learning algorithms. ROC curves demonstrated a strong diagnostic value when the three hub genes were combined. RT-qPCR confirmed the low expression of WBP11 and ACTR2 in RPL, whereas NCSTN exhibited high expression. The immune cell infiltration analysis results indicated an imbalance of macrophages in RPL. Meanwhile, these three hub genes exhibited aberrant expression in multiple malignancies and were associated with a poor prognosis. Furthermore, we identified several small-molecule drugs.ConclusionThis study identifies and validates hub genes in RPL, which may lead to significant advancements in understanding the molecular mechanisms and treatment strategies for this condition.