bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Tai Chi and Qigong Effective in the Treatment of Traumatic Brain Injury? A Systematic Review
Authors: Laskosky Nicole Alexandra , Huston Patricia , Lam Wai Ching , Anderson Charlotte , Zhong Linda LD 
Published: September 2023

Abstract

Background Traumatic brain injury (TBI) adversely affects both young and old and is a growing public health concern. Several recent trends in managing TBI, such as recommending sub-threshold aerobic activity, tailoring multi-modal treatment strategies, and studying the potential role of inflammation in those with persistent symptoms, all suggest that the physical and cognitive exercise of tai chi/qigong could be beneficial. Method The following databases were searched: MEDLINE, CINAHL Cochrane Library, Embase, China National Knowledge Infrastructure Database, Wanfang Database, Chinese Scientific Journal Database, and Chinese Biomedical Literature Database. Cochrane-based risk of bias assessments were conducted on all included trials. Quality of evidence was assessed using the grading of recommendation, assessment, development, and evaluation (GRADE) system. Results Three randomized controlled trials (RCTs) and two non-RCTs were assessed. Four trials used tai chi as the intervention and one trial used qigong. Primary and secondary outcome measures significantly varied amongst all trials. Certainty of evidence by the GRADE assessment was higher for the RCTs than the non-RCTs due primarily to lower risk of bias. All four tai chi trials showed a beneficial outcome for the tai chi group. For the RoB 2.0 scores, one tai chi RCT had a low risk of bias and a high level of certainty by GRADE; one had some concerns. For the ROBINS-I scores, one non-RCTs had a moderate risk of bias and the other a serious risk of bias. The one qigong trial had a low risk of bias and a moderate level of certainty by GRADE. Conclusion Considering the high level of certainty from one RCT and the beneficial effects found in all four trials on tai chi, there is a sufficient signal to merit conducting a multi-centre trial on tai chi for TBI that will increase statistical power and test tai chi against current trends in the management of TBI. Although promising, based on a single trial, the signal for qigong is insufficient at this time; another single centre RCT is indicated. Systematic Review Registration: PROSPERO [CRD42022364385]
A Mendelian randomization study investigating the causal role of inflammation Cytokines on Sarcopenia
Authors: Wei Donglei , Meng Guose , Su Wei , Wei Qingjun , Cheng Jianwen , Zhao Jinmin 
Published: September 2023

Abstract
Background: Sarcopenia is a disorder of the skeletal muscles characterized by a reduction in muscle mass, strength, and function. This investigation investigates the potential causal connection between inflammatory cytokines and sarcopenia.
Methods: Using two genome-wide association studies (GWAS), we performed bidirectional Mendelian randomization (MR) analysis. The statistical analyses mainly included inverse variance-weighted (IVW), weighted median (WM), MR-Egger, Cochran's Q test, MR-Egger intercept analysis, and MR-PRESSO.
Results: By the European Working Group on Sarcopenia in Older People (EWGSOP) criteria, we observed an inverse correlation between IL16 and sarcopenia (IL16, odds ratio [OR]: 0.971, 95% confidence interval [CI]: 0.948-0.995, P = 0.0199). In contrast, IL5 and MIP1b were positively associated with sarcopenia (IL5, OR: 1.063, 95% CI: 1.006-1.124, P = 0.0294; MIP1b, OR: 1.022, 95% CI: 1.001-1.043, P = 0.0375). Using the Foundation for the National Institutes of Health (FNIH) standard, we found an inverse association between IL16 and the risk of developing sarcopenia (IL16, OR: 0.954, 95% CI: 0.917-0.993, P = 0.0223). In contrast, MIP1b showed a positive association with the risk of sarcopenia (MIP1b, OR: 1.027, 95% CI: 1.000-1.055, P = 0.0491). We observed a weak negative correlation between IL16 and appendicular lean mass (ALM) regarding muscle mass analysis (IL16, OR: 0.990, 95% CI: 0.980-0.999, P = 0.0498). Reverse magnetic resonance analysis revealed no causal relationships between sarcopenia and IL16, IL5, or MIP1b.
Conclusion: Our research reveals a negative correlation between IL16 and genetic susceptibility to sarcopenia, indicating that IL16 protects effect on sarcopenia. In contrast, IL5 and MIP1b are positively associated with the risk of sarcopenia, suggesting they may be detrimental to muscle health.
Deep learning-based, fully automated, pediatric brain segmentation
Authors: Kim Min-Jee , Hong EunPyeong , Yum Mi-Sun , Lee Yun-Jeong , Kim jinyoung , Ko Tae-Sung 
Published: September 2023

Abstract
The purpose of this study was to demonstrate the performance of a fully automated, deep learning-based brain segmentation (DLS) method in healthy controls and in patients with neurodevelopmental disorders, SCN1Amutation, under eleven.
The whole, cortical, and subcortical volumes of previously enrolled 21 participants, under 11 years of age, with a SCN1A mutation, and 42 healthy controls, were obtained using a DLS method, and compared to volumes measured by Freesurfer with manual correction. Additionally, the volumes which were calculated with the DLS method between the patients and the control group.
The volumes of total brain gray and white matter using DLS method were consistent with that volume which were measured by Freesurfer with manual correction in healthy controls. Among 68 cortical parcellated volume analysis, the volumes of only 7 areas measured by DLS methods were significantly different from that measured by Freesurfer with manual correction, and the differences decreased with increasing age in the subgroup analysis. The subcortical volume measured by the DLS method was relatively smaller than that of the Freesurfer volume analysis. Further, the DLS method could perfectly detect the reduced volume identified by the Freesurfer software and manual correction in patients with SCN1A mutations, compared with healthy controls.
In a pediatric population, this new, fully automated DLS method is compatible with the classic, volumetric analysis with Freesurfer software and manual correction, and it can also well detect brain morphological changes in children with a neurodevelopmental disorder.
Influence Factors and Prognostic Analysis of Peri-Intraventricular Hemorrhage in Premature Infants using Cranial Ultrasound
Authors: GU Jiaojiao , Liu Chen , Yao Shixiang , Wang Hongying , Yu Hongkui 
Published: September 2023

Abstract
Background
Peri-intraventricular hemorrhage (PIVH) remains a significant cause of mortality in premature infants. This study aimed to grade PIVH using cranial ultrasound and identify relevant factors associated with PIVH grading, with the objective of developing an assessment model to predict the risk of mortality in PIVH premature infants.
Methods
Relevant factors were analyzed to determine their correlation with the severity of PIVH. Logistic regression models and a nomogram were constructed to predict mortality before discharge in premature infants with PIVH.
Results
The results revealed significant associations between gestational age at birth, birth weight, 5-minute Apgar score, invasive ventilation on day 1, mortality before discharge, and length of stay with different degrees of PIVH. A regression model incorporating gestational age at birth, birth weight, and invasive ventilation on day 1 was established to predict the risk of mortality before discharge in premature infants with PIVH.
Conclusions
Low gestational age at birth, low birth weight, low 5-minute Apgar score, and invasive ventilation on day 1 are risk factors for severe PIVH in premature infants. The logistic regression model developed in this study may assist in the early clinical identification of mortality risk in premature infants.
Synthesis of 2,9-dihydropyrano[2,3-b]-indoles via intramolecular Oxa-6π-electrocyclization reaction from synthesized 3-allylideneindolin-2-one intermediates
Authors: Varnakesh Parisa Abbasi , Azizian Javad 
Published: September 2023

Abstract

intramolecular Oxa-6π-electrocyclization reaction are described for 3-allylideneindolin-2-one derivatives in the presence of easily prepared B(HSO4)3 catalyst and their conversion to 2,9-dihydropyrano[2,3-b]-indoles in up to 72% yield under mild condition. 3-allylideneindolin-2-one has been obtained from the reaction of isatin and 1,3-dichloropropene. comfortable synthetic conversions of the products readily lead to pharmacologically interesting numerous functional groups.
Condom use and related factors among 281 MSM in Chengdu, China during the COVID-19 pandemic
Authors: Yang BiHui , Li Yuan , Li Na , He Jia , Liang Shu , YANG YI 
Published: September 2023

Abstract

Background During Coronavirus disease (COVID-19) pandemic, as a sexual minority group, men who have sex with men (MSM) faced risks of COVID-19 and HIV infection at the same time. However, there is no in-depth study on the MSM with their homosexual regular and casual partners during the COVID-19 pandemic. This study is to explore condom use and related factors among MSM during the COVID-19 pandemic, and to provide suggestions for MSM intervention strategies in the post-pandemic era. Methods A cross-sectional study design was used to study the condom use of MSM with regular and casual homosexual partners. Logistic regression was used to analyze related factors of MSM 's consistent condom use, including basic information, HIV/AIDS-related knowledge, HIV/AIDS-related stigma, sexual behavior during the COVID-19 pandemic and self-efficacy of condom use. Results During the COVID-19 pandemic, 112 (65.1%) of 172 MSM having regular homosexual partners insisted on using condoms when having sex with regular homosexual partners, and 119 (66.5%) of 179 MSM with casual homosexual partners. Logistic regression showed that the protective factors of condom use among MSM with their regular partners were self-employed or other occupations (OR = 4.857, 95%CI = 1.008–23.410 ), personal monthly income ≥ 5000 yuan (OR = 9.947, 95%CI = 1.198–82.615), self-reported as bisexuality (OR = 7.290, 95%CI = 1.693–31.395), fear of COVID-19 infection through sexual behavior (OR = 6.822, 95%CI = 1.291–36.067), and high score of condom use efficacy (OR = 1.200, 95% CI = 1.124–1.281). The risk factors were awareness of HIV/AIDS-related knowledge (OR = 0.049, 95%CI = 0.006–0.417) and having heterosexual sex (OR = 0.220, 95%CI = 0.051–0.95). The high score of condom use efficacy (OR = 1.123, 95%CI = 1.069–1.181) was also the protective factor of consistent condom use between MSM with casual homosexual partners, and the risk factors were urban household registration (OR = 0.368, 95%CI = 0.14–0.968), living with family members (OR = 0.261, 95%CI = 0.08–0.849), high score of HIV/AIDS-related stigma (OR = 0.921, 95%CI = 0.848-1), and heterosexual sex (OR = 0.253, 95%CI = 0.076–0.847). Conclusions During the COVID-19 pandemic, MSM had a moderate level of consistent condom use with homosexual regular and casual partners. The use of condom is affected by general demographic characteristics, social psychology, sexual behavior, and other factors, especially in the psychological aspect. Health workers in relevant departments such as disease control and prevention should focus on the psychological problems of MSM, especially in the outbreak of major public health events. Health workers should actively guide and solve MSM’s negative emotions, so as to improve the condom use of MSM during this period.
Predictors of neonatal mortality among neonates admitted to the neonatal intensive care unit at Hawassa University Comprehensive Specialized Hospital, Sidama regional state, Ethiopia
Authors: Taye Kefyalew , Kebede Yenew , Tsegaw Desalegn , Ketema Worku 
Published: September 2023

Abstract

Background Despite promising efforts, substantial deaths occurred during the neonatal period. According to estimates from the World Health Organization(WHO), Ethiopia is among the top 10 nations with the highest number of neonatal deaths in 2020 alone. This staggering amount makes it difficult to achieve the SDG (Sustainable Development Goals) target that calls for all nations to work hard to meet a neonatal mortality rate target of ≤ 12 deaths per 1,000 live births by 2030. We evaluated neonatal mortality and it's contributing factors among newborns admitted to the Neonatal Intensive Care Unit (NICU) at Hawassa University Comprehensive Specialized Hospital (HUCSH). Methods A hospital-based retrospective cross-sectional study on neonates admitted to the NICU from May 2021 to April 2022 was carried out at Hawassa University Comprehensive Specialized Hospital. From the admitted 1044 cases over the study period, 225 babies were sampled using a systematic random sampling procedure. The relationship between variables was determined using bivariate and multivariable analyses, and statistically significant relations were indicated at p-values less than 0.05.Results: The magnitude of neonatal death was 14.2% (95% CI: 0.099–0.195). The most common causes of neonatal death were prematurity 14 (43.8%), sepsis 9 (28.1%), Perinatal asphyxia 6 (18.8%), and congenital malformations 3 (9.4%). The overall neonatal mortality rate was 28 per 1000 neonate days. Neonates who had birth asphyxia were 7.28 times more probable (AOR = 7.28; 95% CI: 2.367, 9.02) to die. Newborns who encountered infection within the NICU were 8.17 times more likely (AOR = 8.17; 95% CI: 1.84, 36.23) to die. Conclusion The prevalence of newborn death is excessively high. To remedy the disparities that have been identified, we demand that antenatal care services be implemented appropriately, delivery care quality be improved, and appropriate neonatal care and treatment be made available.
Geographic Inequalities and Determinants of Aneamia among Preeclamptic Women in Bangladesh
Authors: Ali Md. Ahasan , Islam Jahirul , Paul Ratna , Parvin Shahinur , Chowdhury Abu Taiub Mohammed Mohiuddin , Islam Rafiqul , Siddique Sharmina , Rahman Md Atiqur , Tasnim Sayeda Tamanna , Hasna Suraiya 
Published: September 2023

Abstract
Background
Anaemia is among preeclamptic women's main health problems in Bangladesh. Aneamia affects pregnant women and women of reproductive age who have hemoglobin levels below 11.0 g/dl. In Bangladesh, the prevalence of aneamia among pregnant women is 42.2%, compared to a global incidence of 38.2%, which raises a major public health concern.
Methods
Information from 180 respondents was gathered from the Department of Gynecology and Obstetrics, Preeclampsia (PE) ward at Dhaka Medical College Hospital (DMCH), Dhaka, Bangladesh, between September 2021 and August 2022 [Ethical approval Ref: Memo No. ERC-DMC/ECC/2022/31]. Factors associated with aneamia were explored using the chi-square test, and then we performed multinomial logistic regression (MLR) to determine the level of association with the risk factors. We further conducted cluster analysis, Global Moran’s I, and Anselin local Moran’s I to check the geographical distribution of anaemia cases from our sample.
Results
Early and late PE onset were recorded and classified into two categories; 28.9% of respondents reported an early onset of PE, while 71.1% reported a late onset of PE. A total of 38.9% of subjects had normal hemoglobin counts, whereas 38.3% had mild aneamia. A total of 17.8% had moderate aneamia, and 5.0% had severe aneamia. By performing MLR, anaemia had a statistically significant association with several underlying factors, e.g., recreational substance use (RR = 83.093, 95% CI- 3.351 to 2060.315), gestational age (RR = 10.235, 95% CI- 1.478 to 70.879), gestational diabetes mellitus (RR = 4.906, 95% CI- 1.920 to 12.532), pregnancy interval (RR = 4.374, 95% CI- 1.338 to 4.303), education (RR = 3.448, 95% CI- 1.542 to 7.709), profession (RR = 0.263, 95% CI- 0.109 to 0.635), parity (RR = 0.117, 95% CI- 0.026 to 0.529), and respondent age (RR = 0.160, 95% CI- 0.032 to 0.802). Higher incidence rates for all kinds of aneamia were observed in the Dhaka, Narayanganj, and Munshiganj districts. The global Moran’s I value ranged from 0.14 to 0.44, and high-high cluster regions were detected in the central region.
Conclusions
The risk factors indicated in this study and geographical inequalities will help policymakers take necessary steps. The geographical distribution of the incidence rate raises concern for further research, including sociodemographic and environmental factors. This will assist in determining the determinants of aneamia and suggest possible measures.
How to solve the risk of fiscal burden of the medical insurance fund? Simulation analysis under the universal three-child policy in China
Authors: Zhang Xinjie , Yu Xia , Mao Enrong 
Published: September 2023

Abstract
Background
The aging population poses a huge challenge to the health care system and puts great burden on the financial operation, and has become a common problem faced by countries around the world. Will the implementation of the universal three-child policy enhance the sustainability of medical insurance funds? How to effectively relieve the financial burden?
Method
This study analyzes the sustainability of the medical insurance fund and the financial burden under different fertility levels of the universal three-child policy by constructing a dynamic population projection model and an actuarial model of medical insurance.
Results
Compared with the current fertility policy (fertility rate 1.3), under the adjusted fertility policy (fertility rate 1.4-3.0), the occurrence of the current deficit and accumulated deficit of the medical insurance fund will be gradually postponed, and the fiscal subsidies burden will be significantly alleviated.
Conclusions
The universal three-child policy is conducive to improving the sustainability of the medical insurance fund and reducing the financial pressure, and the effect is more obvious at higher fertility levels. Considering the time-lag of the fertility policy, medical cost control and outpatient co-payment policies should be promoted simultaneously to improve the efficiency of fund utilization and the modernization of medical insurance governance by adjusting the stock.
Trimatch comparison of the prognosis of hypochloremia, normolchloremia and hyperchloremia in patients with septic shock
Authors: Ruan Xiangyuan , Yifan Gao , Wang Baoxin , Wu Jinmei , Yu Xueshu , Lai Xiaojuan 
Published: September 2023

Abstract

Background
Septic shock is a lethal disease, and identifying high-risk patients through noninvasive and widely available biomarkers can help improve global outcomes. While the clinical impact of chloride levels on critically ill patients remains unclear, this study aims to investigate the association between hypochloremia and mortality following ICU admission among septic shock patients.
Methods
This is an analysis of data stored in the databases of Medical Information Mart for Intensive Care IV (MIMIC-IV). The initial chloride levels were classified as hypochloremia, normal chloraemia, and hyperchloraemia. A multivariate logistic regression model was applied, adjusting for age, lactate, pH, PO2, urine volume, RDW, creatinine, and liver disease, to assess the association between the three categories of chloride levels and mortality.
Results
Of 3726 patients included in the study, 470 patients (12.6%) had hypochloremia on ICU admission. During the follow-up period, 1120 (33.5%) patients died. Hypochloremia was significantly associated with increased mortality and the incidence of AKI after adjusting for several variables.
Conclusions
Hypochloremia is independently associated with higher hospital mortality, AKI incidence among septic shock patients. However, further high-quality research is necessary to establish the precise relationship between hypochloremia and septic shock prognosis.
Success skills for the 50/50-split-model: Practicable skills parents can apply in their daily routine to successfully implement an equal split of paid work, childcare, and housework between each other. A qualitative content analysis
Authors: Schaber Ronja , Simm Josefine , Patella Tirza , Garthus-Niegel Susan 
Published: September 2023

Abstract

Background: Many young couples are planning to share paid work, childcare, and housework equally between each other. But implementing such a 50/50-split-model is difficult and parents often return to traditional gender role distributions after the birth of a child. This return has potential negative effects on mental health, physical health, and relationship satisfaction. Therefore, this study aims to find practicable skills in the daily routine for new parents to successfully implement the 50/50-split-model.
Methods: This qualitative study, DREAMTALK, is part of the multi-method, prospective Dresden Study on Parenting, Work, and Mental Health (DREAM). For DREAMTALK, N = 25 parents implementing a 50/50-split-model were selected based on quantitative data regarding time use, which participants had provided in questionnaires. In DREAMTALK, problem-centered interviews were conducted with the selected sample at 17 months postpartum. Those were analyzed via qualitative content analysis, which is systematic, rule-guided, and based on the criteria of validity and reliability.
Results: The qualitative content analysis revealed a catalog of 38 practicable skills to manage daily routine, which can help parents to successfully implement a 50/50-split-model. Individual participants used 23 success skills on average. Examples include having a regular coordination appointment with the other parent, planning foresightedly, flexibility, reducing cleaning, optimization of routes, or moderate split-shift parenting. Some of these skills seem opposing, e.g., planning foresightedly, and at the same time, meeting unpredicted changes with flexibility. Those seemingly opposing skills were well balanced by the participants, which was an additional skill.
Conclusions: The success skills are focusing on strategies parents can use relatively independently of external circumstances. This behavioral perspective extends prior theories, which have focused on explaining unequal gender role distributions with external circumstances. A behavioral perspective can be a gateway to assist more parents to pioneer in implementing the 50/50-split-model, which might in turn lead to a healthier and more satisfied public population.