bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of the prevalence of persistent gastrointestinal symptoms and incidence of new gastrointestinal illness after acute SARS-CoV-2 infection
Authors: Hawkings Michael J. , Vaselli N. Marcella , Charalampopoulos Dimitrios , Brierley Liam , Elliot Alex J. , Buchan Iain , Hungerford Daniel 
Published: April 2023

AbstractIt is known that SARS-CoV-2 infection can result in gastrointestinal symptoms. For some, these symptoms may persist beyond acute infection, in what is known as ‘post-COVID syndrome’. We conducted a systematic review to examine the prevalence of persistent gastrointestinal symptoms and the incidence of new gastrointestinal illness following acute SARS-CoV-2 infection. We searched scientific literature using MedLine, SCOPUS, Embase, Europe PubMed Central, medRxiv and Google Scholar from December 2019 to October 2022. Two reviewers independently identified 28 eligible articles which followed participants for various gastrointestinal outcomes after acute SARS-CoV-2 infection. Study quality was assessed using the Joanna Briggs Institute Critical Appraisal Tools. The weighted pooled prevalence for persistent gastrointestinal symptom of any nature and duration was 10.7%, compared to 4.9% in healthy controls. For six studies at a low risk of methodological bias, the symptom prevalence ranged from 0.2% to 24.1% with a median follow-up time of 13 weeks. We also identified the presence of functional gastrointestinal disorders in historically SARS-CoV-2 exposed individuals. Our review has shown that, from a limited pool of mostly low-quality studies, previous SARS-CoV-2 exposure may be associated with ongoing gastrointestinal symptoms and the development of functional gastrointestinal illness. Furthermore, we show the need for high-quality research to better understand the SARS-CoV-2 association with gastrointestinal symptoms, particularly as population exposure to enteric infections returns to pre-COVID-19-restriction levels.HighlightsAcute SARS-CoV-2 infection can result in gastrointestinal symptomsThe burden of gastrointestinal illness after acute SARS-CoV-2 infection is not knownThis systematic review evaluates the evidence across 28 observational studiesMost studies identified are at high risk of bias and of low qualitySARS-CoV-2 exposure may be associated with new post-infection gastrointestinal illness
Brain network flexibility as a predictor of skilled musical performance
Authors: Uehara Kazumasa , Yasuhara Masaki , Koguchi Junya , Oku Takanori , Shiotani Sachiko , Morise Masanori , Furuya Shinichi 
Published: April 2023

AbstractInteractions between the body and the environment are dynamically modulated by upcoming sensory information and motor execution. To adapt to this behavioral state-shift, brain activity must also be flexible and possess a large repertoire of brain networks so as to switch them flexibly. Recently, flexible internal brain communications, i.e., brain network flexibility, have come to be recognized as playing a vital role in integrating various sensorimotor information. Therefore, brain network flexibility may be one of the key factors that define sensorimotor skill. However, little is known about how flexible communications within a brain characterizes inter-individual variation of sensorimotor skill and trial-by-trial variability within individuals. To address this, we recruited highly skilled musical performers (i.e. brass instrumentalists) and used a novel approach that combined multichannel-scalp electroencephalography (EEG) recordings, behavioral measurements of musical performance, and mathematical approaches to extract brain network flexibility.We found that brain network flexibility immediately before initiating the performance predicted inter-individual differences in the precision of tone timbre (as represented by spectral centroid of the sound), but not trial-by-trial variability at the individual level. Furthermore, brain network flexibility in broader cortical regions, rather than specific local cortical regions, predicted skilled musical performance, indicating that whole-cortical fluctuations determine individual skill. Our results provide novel evidence that brain network flexibility during movement preparation plays an important role in skilled sensorimotor performance and our findings have potentials for designing a new approach to predict an individual’s skill from neural dynamics and a new intervention tool to facilitate physical education.
Synchronized LFP rhythmicity in the social brain reflects the context of social encounters
Authors: Mohapatra Alok Nath , Peles David , Netser Shai , Wagner Shlomo 
Published: April 2023

AbstractMammalian social behavior is highly context-sensitive. Yet, little is known about the mechanisms that modulate social behavior according to its context. Recent studies have revealed a network of mostly limbic brain regions, here termed the “social brain”, which regulates social behavior. We hypothesized that coherent theta and gamma rhythms reflect the organization of the social brain regions into functional networks in a context-dependent manner. To test this concept, we simultaneously recorded extracellular activity from multiple social brain regions in mice performing three social discrimination tasks. Local field potential (LFP) rhythmicity across all tasks was dominated by a general internal state. However, during stimulus investigation LFP rhythmicity was sensitive to stimulus characteristics. Specifically, the pattern of LFP coherence between the various regions reflected mainly the social context. Moreover, we found the ventral dentate gyrus to play a pivotal role in coordinating the context-specific rhythmic activity in the network.
Authentic corporate social responsibility: antecedents and effects on consumer purchase intention
Authors: Mäncher Lars , Zerres Christopher , Breyer-Mayländer Thomas 
Published: April 2023

PurposeThe aim of the research is to identify the factors that create an authentic company's corporate social responsibility (CSR) engagement and to investigate whether an authentic CSR engagement influences the purchase intention. In addition, the study attempts to provide insights into the mediation role of attitude toward the company and frequency of purchase on purchase intention.Design/methodology/approachIn this study, a theoretical framework is developed in which major antecedents of authentic CSR are identified. A specific example of a brand and its corporate social responsibility activities was used for the study. An online questionnaire was used to collect the data. To verify the hypothesis, structural equation modeling with the partial least squares method was used. A total of 240 people participated in the study.FindingsThe results of the study confirmed that CSR authenticity positively influences consumer purchase intention. Furthermore, the hypothesized impact of CSR authenticity on attitudes toward the company and frequency of purchase could be verified.Originality/valueAlthough there is research on the antecedents influencing the consumer's perceived authenticity of CSR, it has not addressed differences in impact and has not presented a full picture of influencing antecedents. In addition, CSR proof as a new antecedent is investigated in the study. Moreover, research on outcomes of perceived CSR authenticity still lacks depth. The study therefore addresses this research gap by providing an extensive research framework including antecedents influencing CSR authenticity and outcomes of CSR authenticity.
Small concept luxury department stores: psychographic characteristics affecting patronage intentions
Authors: Slaton Kelcie , Testa Danielle Sponder 
Published: April 2023

PurposeThe aim of this study is to investigate the psychographic factors of shopping enjoyment, market mavenism and consumer innovativeness and their influence on hedonic and utilitarian values, attitudes and patronage intentions of the small concept luxury department (SCLD) store.Design/methodology/approachThe researchers utilized a quantitative method. An online survey was created and distributed over a three-week period to a representative sample of US luxury consumers. Structural equation modeling (SEM) was used to test the hypothesized relationships among variables.FindingsThe theory of reasoned action (TRA) theoretical framework provided an effective model to investigate the perspectives and behaviors of luxury consumers within the SCLD. The findings of this study suggest the SCLD is an effective store format for consumers who are characterized as market mavens, are considered innovative and enjoy shopping.Practical implicationsThe findings from this research are beneficial to luxury department store retailers looking to invest resources into a new experiential format to appeal to their consumer base.Originality/valueThe research extends the literature in a rapidly evolving area of retail formats and consumer perception by exploring psychographic factors, including shopping enjoyment, market mavenism and consumer innovativeness, and their impact on the beliefs regarding retail formats' hedonic and utilitarian value.
Pragmatic approaches to control inbound sex tourism and prostitution in Thailand and Cambodia: the examination of relevant policy gaps and suggestion of multifaceted policy development
Authors: Hung Jason 
Published: April 2023

PurposeThe essay aims to suggest policies that can help strategically deconstruct and dereproduce the establishment of (child) sexual exploitation in Thailand and Cambodia in phases, for the purpose of upholding child and human rights and rebranding the global image of these two regional commercial sex hubs in the long term.Design/methodology/approachThis essay is constructed based on the theoretical framework of the social control and general strain theories. Supported by the theories, the essay examines what are the socioeconomic determinants driving the prevalence of the (child) commercial sex industry in Thailand and Cambodia. Here the essay highlights and summarises how the (child) commercial sex industry has been constructed and reproduced. Next, the essay presents the existing policy gaps in relation to (child) sex tourism and sex exploitation. Last, and more importantly, the essay delivers perspectives on how Thai and Cambodian lawmakers and policymakers should respond to the severe societal problems of (child) sex trafficking and prostitution in relation to the prevailing sex tourism.FindingsAt the national level, Bangkok and Phnom Penh have an urgent need to rebrand their countries, despite partially allowing commercial sex activities. Moreover, to promote gender equality, Bangkok and Phnom Penh should redistribute their education and occupational opportunities, enabling more school-aged girls or work-aged women to obtain a fairer share of life chances for self-empowerment. At the regional level, Bangkok and Phnom Penh have to tighten regulations against (child) sex exploitation. At the community level, the promotion of community policing can be conducive to minimising any prostitution activities. At the family level, more positive socialisation should be exercised. When more children, including girls, are subsidised to enter school, and are positively parented, there are more educational opportunities for school-aged cohorts.Originality/valueThis essay contains scholarly originality and significance in the presentation of the socioeconomic construction of (child) sexual exploitation, and its relationship to sex tourism and (child) prostitution in Thai and Cambodian contexts, grounded in up-to-date, relevant sociological arguments. A major area that identifies the originality of this essay is the examination of existing, relevant policy gaps in a timely fashion, and correspondingly, the suggestion of policy development that helps deconstruct and deproduce (child) sexual exploitation at the national, regional, community and family levels.
Does the day-of-the-week effect exist in other asset classes? Investigation of the globally listed private equity markets
Authors: Steinborn Marcel 
Published: April 2023

Purpose
This study aims to investigate the day-of-the-week (DoW) effect in globally listed private equity (LPE) markets using daily data covering the period 2004–2021.

Design/methodology/approach
To investigate the existence of the DoW effect in globally LPE markets, ordinary least squares regression, generalised autoregressive conditional heteroscedasticity (GARCH) regression and robust regressions are used. In addition, robustness audits are conducted by subdividing the sampling period into two sub-periods: pre-financial and post-financial crisis.

Findings
Limited statistically significant evidence is found for the DoW effect. By taking time-varying volatility into account, a statistically significant DoW effect can be observed, indicating that the DoW effect is driven by time-varying volatility. Economic significance is captured through visual inspection of average daily returns, which illustrate that Monday returns are lower than the other weekdays.

Practical implications
The results have important implications on whether to adopt a DoW strategy for investors in LPE. The findings show that higher returns on selected days of the week for certain indices are possible.

Originality/value
To the best of the author’s knowledge, this paper provides the first study to examine the DoW effect for globally LPE markets by using LPX indices and contributes valuable insights on this growing asset class.
The haemodynamic effects of phenylephrine after cardiac surgery
Authors: Juhl‐Olsen Peter , Berg‐Hansen Kristoffer , Nørskov Jesper , Enevoldsen Johannes , Hermansen Johan Lyngklip 
Published: April 2023

AbstractBackgroundPhenylephrine increases systemic‐ and pulmonary resistances and therefore may increase blood pressures at the expense of blood flow. Cardio‐pulmonary bypass alters vasoreactivity and many patients exhibit chronotropic insufficiency after cardiac surgery. We aimed to describe the haemodynamic effects of phenylephrine infusion after cardiac surgery.MethodsPatients in steady state after low‐risk cardiac surgery received incremental infusion rates of phenylephrine up to 1.0 μg/kg/min with the aim of increasing systemic mean arterial blood pressure 20 mmHg. Invasive haemodynamic parameters, including pulmonary wedge pressures, were captured along with echocardiographic measures of biventricular function before, during phenylephrine infusion at target systemic blood pressure, and 20 min after phenylephrine discontinuation.ResultsThirty patients were included. Phenylephrine increased mean arterial pressure increased from 78 (±9) mmHg to 98 (±10) mmHg with phenylephrine infusion. Also, pulmonary blood pressure as well as systemic‐ and pulmonary resistances increased. The ratio between systemic‐ and pulmonary artery resistances did not change statistically significantly (p = .59). Median cardiac output was 4.35 (interquartile range [IQR] 3.6–5.4) L/min at baseline and increased significantly with phenylephrine infusion (median Δcardiac output was 0.25 [IQR 0.1–0.6] L/min) (p = .012). Pulmonary artery wedge pressure increased from 10.2 (±3.0) mmHg to 11.9 (±3.4) mmHg (p < .001). This was accompanied by significant increases in central venous pressure. Phenylephrine infusion increased left ventricular end‐diastolic volume from 105 (±46) mL to 119 (±44) mL (p < .001). All results of phenylephrine infusion were reversed with discontinuation.ConclusionIn haemodynamically stable patients after cardiac surgery, phenylephrine increased PVR and SVR, but did not change the PVR/SVR ratio. Phenylephrine increased biventricular filling pressures and left ventricular end‐diastolic area. Consequently, CO increased as ejection fraction was maintained. These findings do not discourage the use of phenylephrine after low‐risk cardiac surgery.Registration: clinicaltrial.gov (identifier NCT04419662).
Lack of the transcription factor Nfix causes tachycardia in mice sinus node and rats neonatal cardiomyocytes
Authors: Landi Sara , Giannetti Federica , Benzoni Patrizia , Campostrini Giulia , Rossi Giuliana , Piantoni Chiara , Bertoli Giorgia , Bonfanti Chiara , Carnevali Luca , Bucchi Annalisa , Baruscotti Mirko , Careccia Giorgia , Messina Graziella , Barbuti Andrea 
Published: April 2023

AbstractAimsNfix is a transcription factor belonging to the Nuclear Factor I (NFI) family comprising four members (Nfia, b, c, x). Nfix plays important roles in the development and function of several organs. In muscle development, Nfix controls the switch from embryonic to fetal myogenesis by promoting fast twitching fibres. In the adult muscle, following injury, lack of Nfix impairs regeneration, inducing higher content of slow‐twitching fibres. Nfix is expressed also in the heart, but its function has been never investigated before. We studied Nfix role in this organ.MethodsUsing Nfix‐null and wild type (WT) mice we analyzed: (1) the expression pattern of Nfix during development by qPCR and (2) the functional alterations caused by its absence, by in vivo telemetry and in vitro patch clamp analysis.Results and ConclusionsNfix expression start in the heart from E12.5. Adult hearts of Nfix‐null mice show a hearts morphology and sarcomeric proteins expression similar to WT. However, Nfix‐null animals show tachycardia that derives form an intrinsic higher beating rate of the sinus node (SAN). Molecular and functional analysis revealed that sinoatrial cells of Nfix‐null mice express a significantly larger L‐type calcium current (Cacna1d + Cacna1c). Interestingly, downregulation of Nfix by sh‐RNA in primary cultures of neonatal rat ventricular cardiomyocytes induced a similar increase in their spontaneous beating rate and in ICaL current. In conclusion, our data provide the first demonstration of a role of Nfix that, increasing the L‐type calcium current, modulates heart rate.
Convenience yield and real exchange rate dynamics: A present‐value interpretation
Authors: Chou Yu‐Hsi , Yen Chia‐Yi 
Published: April 2023

AbstractIn this paper, we empirically investigate the relationship between the convenience yield of government bonds and the real exchange rates using monthly data from 1999 to 2018. We extend the conventional models, based on the present‐value relationship between the real exchange rate and economic fundamentals, while explicitly considering the role of the convenience yield. Empirical results suggest that our present‐value models can capture the dynamic properties of the real exchange rate documented in the literature, including high persistence, excess volatility and excess co‐movement compared with real interest rate differentials. We also find that the sum of expected convenience yields significantly drives real exchange rate movements. Moreover, we find that foreign exchange swap market friction also plays a role in explaining real exchange rates. Finally, we find that monetary policy at the zero lower bound may be essential in real exchange rate modelling.
Performance evaluation of a computer‐aided polyp detection system with artificial intelligence for colonoscopy
Authors: Chino Akiko , Ide Daisuke , Abe Seiichiro , Yoshinaga Shigetaka , Ichimasa Katsuro , Kudo Toyoki , Ninomiya Yuki , Oka Shiro , Tanaka Shinji , Igarashi Masahiro 
Published: April 2023

ObjectivesA computer‐aided detection (CAD) system was developed to support the detection of colorectal lesions by deep learning using video images of lesions and normal mucosa recorded during colonoscopy. The study's purpose was to evaluate the stand‐alone performance of this device under blinded conditions.MethodsThis multicenter prospective observational study was conducted at four Japanese institutions. We used 326 videos of colonoscopies recorded with patient consent at institutions in which the Ethics Committees approved the study. The sensitivity of successful detection of the CAD system was calculated using the target lesions, which were detected by adjudicators from two facilities for each lesion appearance frame; inconsistencies were settled by consensus. Successful detection was defined as display of the detection flag on the lesion for more than 0.5 s within 3 s of appearance.ResultsOf the 556 target lesions from 185 cases, detection success sensitivity was 97.5% (95% confidence interval [CI] 95.8–98.5%). The “successful detection sensitivity per colonoscopy” was 93% (95% CI 88.3–95.8%). For the frame‐based sensitivity, specificity, positive predictive value, and negative predictive value were 86.6% (95% CI 84.8–88.4%), 84.7% (95% CI 83.8–85.6%), 34.9% (95% CI 32.3–37.4%), and 98.2% (95% CI 97.8–98.5%), respectively.Trial registrationUniversity Hospital Medical Information Network (UMIN000044622).
Participant perspectives on cognitive remediation and social recovery in early psychosis (CReSt‐R): An acceptability study
Authors: Frawley Emma , Heary Caroline , Berry Clio , Cella Matteo , Fowler David , Wykes Til , Donohoe Gary 
Published: April 2023

AbstractAimPsychosis spectrum disorders continue to rank highly among causes of disability. This has resulted in efforts to expand the range of treatment targets beyond symptom remission to include other recovery markers, including social and occupational function and quality of life. Although the efficacy of psychosocial interventions in early psychosis has been widely reported, the acceptability of these interventions is less well‐known. This study explores the participant perspective on a novel, psychosocial intervention combining cognitive remediation and social recovery therapy.MethodsWe employed a qualitative research design, based on semi‐structured interviews and reflexive thematic analysis. Six participants with early psychosis were recruited from the intervention arm of a randomized pilot study, three women and three men, aged between 22 and 27 years.ResultsFour themes were developed through the analytical process, namely, (1) a solid therapeutic foundation, (2) multi‐directional flow of knowledge, (3) a tailored toolset, and (4) an individual pathway to recovery. Participants also provided pragmatic feedback about how to improve the delivery of the therapy assessments and intervention. Both the themes and pragmatic feedback are described.ConclusionsPeople with early psychosis described the intervention as acceptable, engaging, helpful and person‐centred, suggesting its potential role in a multicomponent therapy model of early intervention in psychosis services. Participants in this study also highlight the importance of an individualized approach to therapy, the vital role of the therapeutic relationship and the ecological validity and value of adopting an assertive outreach delivery, providing therapy outside a conventional clinic setting.