bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safe Reproducible Breast Reduction
Authors: Faulkner Heather R. , Merceron Tyler , Wang Jennifer , Losken Albert 
Published: September 2023

Summary:
Breast reduction is a common operation performed by plastic surgeons. Patients can have significant improvement in physical symptoms in addition to increased self-esteem, body image, and quality of life as a result. The authors describe common techniques for breast reduction and provide representative photographs and videos of these techniques. An evidence-based review is provided for patient selection criteria, common surgical techniques, and methods to avoid and treat complications. Information is also provided on patient education about breast reduction. In most cases, breast reduction is safe to perform in the outpatient setting. The Wise pattern and vertical pattern are among the most common techniques for skin incisions, and the inferior and superomedial pedicles are two of the most common pedicles used in breast reduction. Enhanced Recovery After Surgery protocols are helpful to effectively control pain and reduce narcotic use postoperatively. Patient satisfaction after breast reduction surgery is typically high. Multiple techniques are available to successfully perform breast reduction. The plastic surgeon needs to select patients carefully and determine the appropriate technique to use. Patient education about the operation, recovery, expected result, and risks is an important component of achieving an optimal result.
A nomogram for predicting the risk of preeclampsia in women with intrahepatic cholestasis of pregnancy based on prenatal monitoring time: a multicenter retrospective cohort study
Authors: Cai Qin-Yu , Li Zhuo-Hang , Deng Bei-Ning , Luo Xin , Lan Xia , Chen Ya , Liang Li-Fang , Liu Chen-Yang , Liu Tai-Hang , Wang Ying-Xiong , Wang Lan 
Published: September 2023

Background and aims:
Intrahepatic cholestasis of pregnancy (ICP) is a special liver disease during pregnancy, characterized by abnormal bile acid metabolism. However, there is no consensus on how to group women with ICP based on the time of diagnosis worldwide. This study aimed to adopt a new grouping model of women with ICP, and the time from diagnosis to delivery was defined as the monitoring period.

Methods:
This retrospective real-world data study was conducted across multiple centers and included 3172 women with ICP. The study first evaluated the significant difference in medication and nonmedication during different monitoring times. The least absolute shrinkage and selection operator (LASSO) model was then used to screen nine risk factors based on the predictors. The model's discrimination, clinical usefulness, and calibration were assessed using the area under the receiver operating characteristic (ROC) curve, decision curve, and calibration analysis.

Results:
The incidence of preeclampsia risk in ICP patients without drug intervention increased with the extension of the monitoring period. However, the risk of preeclampsia decreased in ICP patients treated with ursodeoxycholic acid. A predictive nomogram and risk score model was developed based on nine risk factors. The area under the ROC curve of the nomogram was 0.765 [95% confidence interval (CI): 0.724–0.807] and 0.812 (95% CI: 0.736–0.889) for the validation cohort.

Conclusions:
This study found that a longer ICP monitoring period could lead to adverse pregnancy outcomes in the absence of drug intervention, especially preeclampsia. A predictive nomogram and risk score model was developed to better manage ICP patients, maintain pregnancy to term delivery, and minimize the risk of severe adverse maternal and fetal outcomes.
Clinicopathological features and prognosis of synchronous and metachronous colorectal cancer: a retrospective cohort study
Authors: Fan Hao , Wen Rongbo , Zhou Leqi , Gao Xianhua , Lou Zheng , Hao Liqiang , Meng Ronggui , Gong Haifeng , Yu Guanyu , Zhang Wei 
Published: September 2023

Background:
To investigate the clinicopathological features and prognosis of synchronous and metachronous multiple primary colorectal cancer.

Materials and methods:
Patients who underwent operation for synchronous and metachronous colorectal cancer at the colorectal surgery department of XX Hospital between January 2000 and December 2021 were included. Perioperative indicators were comprehensively compared and included in the survival analyses.

Results:
In total, 563 patients with synchronous (n=372) and metachronous (n=191) colorectal cancer were included. Patients with synchronous colorectal cancer were more likely to have a long onset time, positive carcinoembryonic antigen, advanced TNM stage, large tumor, perineural invasion, p53 high expression, and mismatch repair proficient. Compared with metachronous colorectal cancer, patients with synchronous colorectal cancer showed worse 5-year overall survival (68.6%±3.0% vs 81.9%±3.5%, P=0.018) and 5-year disease-free survival (61.2%±3.1% vs 71.0%±3.9%, P=0.022). In the subgroup analysis, segmental resection was an independent risk factor for the long-term outcomes of bilateral synchronous colorectal cancer.

Conclusions:
Clinicopathological and molecular features were different between synchronous and metachronous colorectal cancer. Patients with synchronous colorectal cancer showed a worse prognosis than those with metachronous colorectal cancer. Bilateral synchronous colorectal cancer requires extended resection to achieve improved long-term outcomes.
Prevalence and associated factors of vitamin D deficiency after Roux-en-Y gastric bypass: A systematic review and meta-analysis
Authors: Gao Zhiguang , Liang Yuzhi , Huang Shifang , Wu Zhenpeng , Li Min , Yang Jingge 
Published: September 2023

Objects:
To estimate the prevalence and associated factors of vitamin D deficiency (VDD) after Roux-en-Y gastric bypass (RYGB).

Methods:
PubMed, EMBASE, and CENTRAL were searched for relevant records from inception to March 17, 2023, using search terms: vitamin D, vitamin D3, vitamin D deficiency, hypovitaminosis D, gastric bypass, and RYGB. Studies were eligible for inclusion if they provided related data on VDD prevalence after RYGB.

Results:
Of 1119 screened studies, 72 studies involving 7688 individuals were enrolled in the final analysis. The prevalence estimates of VDD after RYGB were 42%. Subgroup analyses suggested the pooled prevalence of postoperative VDD was 35% for follow-up duration ≤1 year, 43% for >1 and ≤5 years, and 54% for >5 years. Meta-regression showed that VDD prevalence was positively correlated with follow-up time. Also, the prevalence was higher in studies with inadequate vitamin D supplementation than in those with adequate supplementation and in Asia population than in those from South America, Europe, and North America. Other factors associated with high VDD prevalence after RYGB included high presurgical VDD prevalence, non-compliant patients, and black populations. No significant association existed between VDD and alimentary length.

Conclusion:
VDD presented a high prevalence in patients following RYGB. It occurred more frequently with longer postoperative follow-up time. Population-specific vitamin D supplementation measures, targeted treatment for presurgical VDD, improved patient compliance, and periodical follow-ups were necessary to reduce VDD and other adverse outcomes.
Threatening Beliefs About Self and Others Moderate the Association Between Psychoticism and Psychological Distress
Authors: Cheli Simone , Cavalletti Veronica , Hopwood Christopher J. 
Published: September 2023

Abstract
Psychoticism is a multidimensional personality construct involving odd or eccentric behavior, quasi-psychotic experiences, mistrust, interpersonal detachment, and liability for schizophrenia-spectrum disorders, as well as significant distress. Recent advances suggest it can be understood as a dimension that is continuously distributed in the population, leading to questions about factors that contribute to distress and dysfunction among people with a schizotypal liability. We investigated in a large nonclinical sample of young adults whether associations between psychoticism and psychological distress would increase in the presence of threatening beliefs. In our study (N = 2127), we found that the association between psychoticism and psychological distress is moderated by threatening beliefs including self-criticism, fear of compassion, and socially prescribed perfectionism. These results suggest that distress increases among people with schizotypal traits in the context of negative beliefs about self and others. We discuss implications for clinical practice and directions for further research.
Pinloc or Hansson pins: a multicenter, randomized controlled study of 439 patients treated for femoral neck fractures
Authors: Åberg Henrik , Kalland Kristine , Jonsson Kenneth B. , Johansson Torsten 
Published: September 2023

Abstract

Objectives:
To compare the recently developed Hansson Pinloc system, which features 3 cylindrical parallel pins with hooks connected through a fixed-angle interlocking plate, with the Hansson Pin System (2 hook pins) for the treatment of femoral neck fractures.

Design:
One hundred fourteen patients with displaced femoral neck fractures and 325 patients with nondisplaced fractures from 9 orthopaedic centers were randomized to either Hansson Pinloc system or Hansson Pin System and followed for 2 years or until death. Age at inclusion was 50 years or older.

Main Outcome Measurements:
The primary outcome was failure (defined as early displacement, nonunion, symptomatic avascular necrosis, or deep infection). Secondary outcomes included revision surgery, Timed Up and Go (TUG) test and patient-reported outcome measures (PROMs: EQ-5D and WOMAC).

Results:
For nondisplaced fractures, the incidence of failure was 14% (23/169) in the Pinloc group and 16% (25/156) in the Hansson group. For displaced fractures, the analysis was stratified by age. Patients aged 50–69 years with displaced fractures showed a 2-year failure rate of 44% (17/39) in the Pinloc group versus 44% (16/36) in the Hansson group. For patients 70 years or older with displaced fractures, 33% (7/21) in the Pinloc group versus 22% (4/18) in the Hansson group failed. At 3 and 12 months, no clinically significant differences between treatment groups were found for EQ-5D-3L, WOMAC, or for the TUG in any fracture type or age group.

Conclusions:
There were no advantages for Pinloc in any of the studies aspects.

Level of evidence:
1
Management of complex wrist fractures with volar and dorsal locked (double-locked) K-lock
Authors: du Plessis Prieur , Fournier Marie-Cecile 
Published: September 2023

Abstract:
This article is a technical note to outline a novel technique of fixation in complex, comminuted distal radius fractures using a double-locked K-wire construct using a new implant called K-lock. In these (AO) C-type fractures, with significant dorsal comminution, it is often difficult to attain stable and secure fixation of the dorsal rim fragments, especially the dorsal lunate fossa fragment. This often results in patients being treated by temporary spanning devices or asking to have a restricted use of the hand during a given period to avoid loss of position. If dorsal plating is necessary, because of the severity of the comminution, a double-locked K-wire (locked in both the dorsal and volar plates) offers a fixation option and may create a significantly stronger construct and allow confident early mobilization. The K-lock was recently launched by Newclip Technics as an adjunct to the Xpert Wrist 2.4 set as a fragment-specific fixation option. The wire has less chance of displacing or fracturing the fragment and has a smooth surface compared with a screw; this wire would be safer close to the joint in severe distal intra-articular comminution. Of the 9 cases performed so far (as is our usual practice), despite the complexity of the fractures, none were immobilized postoperatively and all started hand therapy in the first week. Most were driving by 2 weeks and returned to light work at 4 weeks and heavy work or sports at 6 to 8 weeks. This principle of fixation may also be extended to other fractures where dual plating is used.
Ohio Coronavirus Wastewater Monitoring Network: Implementation of Statewide Monitoring for Protecting Public Health
Authors: Bohrerova Zuzana , Brinkman Nichole E. , Chakravarti Ritu , Chattopadhyay Saurabh , Faith Seth A. , Garland Jay , Herrin James , Hull Natalie , Jahne Michael , Kang Dae-Wook , Keely Scott P. , Lee Jiyoung , Lemeshow Stan , Lenhart John , Lytmer Eva , Malgave Devesh , Miao Lin , Minard-Smith Angela , Mou Xiaozhen , Nagarkar Maitreyi , Quintero Anda , Savona Francesca D. R. , Senko John , Slonczewski Joan L. , Spurbeck Rachel R. , Sovic Michael G. , Taylor R. Travis , Weavers Linda K. , Weir Mark 
Published: September 2023

Context:
Prior to the COVID-19 pandemic, wastewater influent monitoring for tracking disease burden in sewered communities was not performed in Ohio, and this field was only on the periphery of the state academic research community.

Program:
Because of the urgency of the pandemic and extensive state-level support for this new technology to detect levels of community infection to aid in public health response, the Ohio Water Resources Center established relationships and support of various stakeholders. This enabled Ohio to develop a statewide wastewater SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) monitoring network in 2 months starting in July 2020.

Implementation:
The current Ohio Coronavirus Wastewater Monitoring Network (OCWMN) monitors more than 70 unique locations twice per week, and publicly available data are updated weekly on the public dashboard.

Evaluation:
This article describes the process and decisions that were made during network initiation, the network progression, and data applications, which can inform ongoing and future pandemic response and wastewater monitoring.

Discussion:
Overall, the OCWMN established wastewater monitoring infrastructure and provided a useful tool for public health professionals responding to the pandemic.
Utilization of Rectal Examinations Before Magnetic Resonance Defecography Studies
Authors: Schrum Colby J. , Dickinson Micaela M. , Shah Eric D. , Speicher Mark R. , Strohbehn Kris 
Published: September 2023

Importance
More information is needed to guide referring subspecialists on the appropriate patient evaluation before magnetic resonance defecography (MRD).

Objectives
This study aimed to evaluate how often health care providers perform digital rectal examination (DRE) before ordering MRD to investigate causes of bowel and pelvic floor complaints.

Study Design
We conducted a retrospective cohort review, including MRD performed on female patients at an integrated health care system from 2016 through 2020. The primary outcome was the presence or absence of documented rectal examination in the year before defecography by the referring provider or 6 months prior by a primary care physician or pelvic floor physical therapist. We hypothesized that the overall rate of rectal examination would be high and unaffected by the referring provider's subspecialty.

Results
Three hundred-four defecography tests were performed, with 209 patients (68.8%) referred by gastroenterology providers and 95 (31.2%) from other specialties. Gastroenterologists performed DRE in 32.8% of patients, in contrast to 84.4% of patients referred by other specialties (P < 0.001). When comparing subspecialties that most commonly refer patients for MRD (gastroenterology, colorectal surgery and urogynecology), there was a statistically significant difference between gastroenterologists and colorectal surgeons (P < 0.001) as well as urogynecologists (P < 0.001) but no difference in the rate of rectal examination between colorectal surgeons and urogynecologists (P = 1.00).

Conclusions
At our single integrated health system, the rate of DRE before MRD testing varied significantly by specialty. Our findings highlight the need for better understanding of DRE utility in the algorithms for evaluation of bowel and pelvic floor disorders.
Transobturator Versus Minisling for Urinary Incontinence: A Randomized Controlled Trial
Authors: Barachisio Lisboa Rodrigo Bartilloti , Faber Marcelo de Arruda , Pereira Glaucia Miranda Varella , de Castro Edilson Benedito , Camargo Ana Carolina Marchesini , Juliato Cássia Raquel Teatin , Brito Luiz Gustavo Oliveira 
Published: September 2023

Importance
The comparison between single-incision slings (SISs) and midurethral slings has been documented in the literature, but results vary according to the SIS device.

Objectives
The purpose of this study is to assess whether SIS (Solyx) is noninferior to transobturator (TOT) (Obtryx) sling for treating women with confirmed stress-predominant urinary incontinence.

Study Design
A prospective, parallel, nonblinded, multicenter, noninferiority, randomized controlled study with 114 patients were randomized and followed 6 and 12 months after surgery. Interventions were midurethral TOT sling (Obtryx—halo; n = 58) or SIS (Solyx; n = 56). The primary outcome was improvement in the Patient Global Impression of Improvement (PGI-I). Secondary outcomes were the Kings Health Questionnaire (KHQ) instruments after treatment, subjective improvement, and surgical outcomes.

Results
Both groups were homogeneous (P = NS) regarding sociodemographic and clinical variables. There was improvement in the PGI-I after 6 (P = 0.001) and 12 months (P = 0.001) of treatment for women who underwent TOT sling. After 6 months, KHQ scores improved in the TOT group for the following domains: role limitations (P = 0.026) and physical limitations (P = 0.006). After 12 months, the TOT group presented better KHQ scores that were statistically significant from the SIS group in incontinence impact (P = 0.012), physical limitations (P = 0.001), and severity measures (P = 0.017). Moreover, the TOT group presented higher subjective improvement after 6 months (P = 0.006) than the SIS group. Mesh erosion was higher in the SIS group (P = 0.006). Reoperations were not statistically different between groups

Conclusion
There were higher scores in the PGI-I score and higher subjective improvement for the TOT sling after 6 and 12 months of treatment when compared with the SIS group.
Innovative Combination Treatment to Expand the Indications of Particle Therapy: Spacer Placement Surgery Using Bio-Absorbable Polyglycolic Acid Spacer
Authors: Komatsu Shohei , Wang Tianyuan , Terashima Kazuki , Demizu Yusuke , Anzai Makoto , Suga Masaki , Yamashita Tomohiro , Suzuki Osamu , Okimoto Tomoaki , Sasaki Ryohei , Fukumoto Takumi 
Published: September 2023

BACKGROUND:
Particle therapy has favorable dose distribution and high curability. However, radiotherapy for malignant tumors adjacent to the gastrointestinal tract is contraindicated owing to its low tolerance. To overcome this, combination treatment with surgery to make a space between the tumor and adjacent gastrointestinal tract followed by particle therapy has been developed. Several materials have been used for the spacer and recently, we developed the absorbable polyglycolic acid (PGA) spacer, which has been used since 2019. This study is the first report of consecutive case series of spacer placement surgery using the PGA spacer.

STUDY DESIGN:
Fifty consecutive patients undergoing spacer placement surgery with the PGA spacer were evaluated. Postoperative laboratory data, morbidity related to the treatment, and spacer volume after treatment were evaluated.

RESULTS:
There were no treatment-related deaths, and all but 2 patients completed combination treatment. The median ratios of postoperative PGA spacer volume to the pretreatment volume were 96.9%, 87.7%, and 74.6% at weeks 2, 4, and 8, respectively. The spacer volume was maintained at 80% at 7 weeks and was predicted to be 50% at 15 weeks and 20% in 24 weeks.

CONCLUSIONS:
Spacer placement surgery using the PGA spacer was feasible and tolerable. The PGA spacers maintained sufficient thickness during the duration of subsequent particle therapy. Combination treatment using the PGA spacer is innovative and has the potential to become a new standard curative local treatment.
Multiple systemic infections caused by Rhodococcus equi: case report
Authors: Li Ning , Wu Changsheng , Cao Pengju , Chen Dongjie , Chen Falin , shen Xiuqing 
Published: September 2023

Abstract
Background: Rhodococcusequi is one of the most important causes of zoonotic infections from grazing animals, posing a particular risk to immunocompromised individuals and those undergoing long-term immunosuppressive therapy.
Case presentation: We report a case of Rhodococcusequi infection in a 65-year-old man with a medical history of diabetes, hypertension, and adult-onset Still’s disease who was, on long-term hormone therapy. The non-HIV-infected patient had blood, lung tissue, and sputum samples that were infected with Rhodococcusequi. Initially, the patient’s condition failed to improve with multiple therapies, including vancomycin and meropenem. Although the symptoms improved after adjusting for antibiotics according to susceptibility, the patient did not completely recover upon discharge.
Conclusions: In recent years, the number of Rhodococcusequi cases has increased. Herein, we describe lethal case of Rhodococcusequi infection in a non-HIV-infected patient.
Neural Data Transformer 2: Multi-context Pretraining for Neural Spiking Activity
Authors: Ye Joel , Collinger Jennifer L. , Wehbe Leila , Gaunt Robert 
Published: September 2023

AbstractThe neural population spiking activity recorded by intracortical brain-computer interfaces (iBCIs) contain rich structure. Current models of such spiking activity are largely prepared for individual experimental contexts, restricting data volume to that collectable within a single session and limiting the effectiveness of deep neural networks (DNNs). The purported challenge in aggregating neural spiking data is the pervasiveness of context-dependent shifts in the neural data distributions. However, large scale unsupervised pretraining by nature spans heterogeneous data, and has proven to be a fundamental recipe for successful representation learning across deep learning. We thus develop Neural Data Transformer 2 (NDT2), a spatiotemporal Transformer for neural spiking activity, and demonstrate that pretraining can leverage motor BCI datasets that span sessions, subjects, and experimental tasks. NDT2 enables rapid adaptation to novel contexts in downstream decoding tasks and opens the path to deployment of pretrained DNNs for iBCI control. Code:https://github.com/joel99/context_general_bci