bluuebunny/crossref_metadata_2025_split huggingface dataset:
The genome sequence of the common green furrow bee, Lasioglossum morio (Fabricius, 1793)
Authors: Falk Steven ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective, Monks Joseph ,   Darwin Tree of Life Consortium
Published: January 2023

We present a genome assembly from an individual male Lasioglossum morio (the common green furrow bee; Arthropoda; Insecta; Hymenoptera; Halictidae). The genome sequence is 547 megabases in span. Over half of the assembly (55.79%) is scaffolded into 12 chromosomal pseudomolecules. The mitochondrial genome was also assembled, and is 16.8 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,460 protein coding genes.
A radio- and fluorescently labelled tracer for imaging and quantification of bacterial infection on orthopaedic prostheses
Authors: Welling Mick M. , Warbroek Kim , Khurshid Chrow , van Oosterom Matthias N. , Rietbergen Daphne D. D. , de Boer Mark G. J. , Nelissen Rob G. H. H. , van Leeuwen Fijs W. B. , Pijls Bart G. , Buckle Tessa 
Published: January 2023

Aims Arthroplasty surgery of the knee and hip is performed in two to three million patients annually. Periprosthetic joint infections occur in 4% of these patients. Debridement, antibiotics, and implant retention (DAIR) surgery aimed at cleaning the infected prosthesis often fails, subsequently requiring invasive revision of the complete prosthetic reconstruction. Infection-specific imaging may help to guide DAIR. In this study, we evaluated a bacteria-specific hybrid tracer (99mTc-UBI29-41-Cy5) and its ability to visualize the bacterial load on femoral implants using clinical-grade image guidance methods. Methods 99mTc-UBI29-41-Cy5 specificity for Stapylococcus aureus was assessed in vitro using fluorescence confocal imaging. Topical administration was used to highlight the location of S. aureus cultured on femoral prostheses using fluorescence imaging and freehand single photon emission CT (fhSPECT) scans. Gamma counting and fhSPECT were used to quantify the bacterial load and monitor cleaning with chlorhexidine. Microbiological culturing helped to relate the imaging findings with the number of (remaining) bacteria. Results Bacteria could be effectively stained in vitro and on prostheses, irrespective of the presence of biofilm. Infected prostheses revealed bacterial presence on the transition zone between the head and neck, and in the screw hole. Qualitative 2D fluorescence images could be complemented with quantitative 3D fhSPECT scans. Despite thorough chlorhexidine treatments, 28% to 44% of the signal remained present in the locations of the infection that were identified using imaging, which included 500 to 2,000 viable bacteria. Conclusion The hybrid tracer 99mTc-UBI29-41-Cy5 allowed effective bacterial staining. Qualitative real-time fluorescence guidance could be effectively combined with nuclear imaging that enables quantitative monitoring of the effectiveness of cleaning strategies. Cite this article: Bone Joint Res 2023;12(1):72–79.
Continuous variable quantum key distribution with a shared partially characterized entangled source
Authors: Du Shanna , Wang Pu , Liu Jianqiang , Tian Yan , Li Yongmin 
Published: January 2023

Locking the sophisticated and expensive entanglement sources at the shared relay node is a promising choice for building a star-type quantum network with efficient use of quantum resources, where the involved parties only need to equip low-cost and simple homodyne detectors. Here, to our best knowledge, we demonstrate the first experimental continuous variable quantum key distribution with an entanglement source between the two users. We consider a practical partially characterized entangled source and establish the security analysis model of the protocol under realistic conditions. By applying a biased base technology, the higher key rate than that of the original protocol is achieved. The experimental results demonstrate that the distance between two users can reach up to 60 km over telecom single-mode fiber, implying the feasibility for high-rate and secure communication with a shared entangled source at metropolitan distances.
Systematic study on size and temporal dependence of micro-LED arrays for display applications
Authors: Nie Junyang , Zhang Zhi , Chen Kongjie , Liu Yifeng , He Shuang , Huang Zhonghang , Zhang Xiaoning , Sun Jie , Zhang Fan , Wu Yongsheng , Yan Qun 
Published: January 2023

Micro-LEDs are one of the most promising candidates for next-generation displays, yet they are inconvenienced by the efficiency reduction induced by the sidewall defects when pursuing further scaled-down device dimensions. We have systematically investigated both the size and temporal dependence of micro-LEDs. Micro-LED arrays with a mesa size ranging from 7 to 100 μm were prepared for display purposes. The luminance and external quantum efficiency (EQE) were measured and discussed. Surprisingly, micro-LED arrays with a smaller mesa size exhibit a higher EQE under 100 ns pulse duration operation when compared with longer pulse duration operations. Under certain short-pulsed excitation, a 7×7  μm2 micro-LED array even exhibits a >20% higher EQE as compared to the direct current (DC) or the long duration pulse operation condition. We thus concluded that the notorious efficiency reduction induced by sidewall defects in small-sized micro-LED arrays could be significantly reduced by applying short-pulse voltages.
Adherence to and experiences of K–12 students in modified and standard home quarantine during the SARS-CoV-2 pandemic in Missouri
Authors: Worrell Mary Claire , Malone Sara , Dawson Patrick , Fritz Stephanie A. , Thomas Ebony , Peeler Bre , Rains Catherine , Tinker Sarah C. , Neatherlin John C. , Barrios Lisa , Mooney Jon , Towns Katie , Newland Jason , Salzer Johanna S. 
Published: January 2023

Background
In November 2020, during the SARS-CoV-2 pandemic, Missouri allowed local public health jurisdictions the option to implement a modified quarantine policy allowing kindergarten through 12 (K-12) students with low-risk exposures to continue in-person learning. We assessed adherence to quarantine among participants in modified quarantine and standard home quarantine and the psychosocial impacts of quarantine on students and families.

Methods
In January-March 2021, as part of an investigation of in-school transmission of SARS-CoV-2, parents of 586 participating K-12 students identified as a close contact with a person with SARS-CoV-2 were sent a survey to assess their activities and psychosocial impacts to the child and family.

Results
Among the 227 (39%) survey respondents, 26 (11%) participated in modified quarantine and 201 (89%) participated in standard home quarantine. Forty-six percent of students in modified quarantine and 72% of students in standard home quarantine reported abstaining from non-school activities during quarantine. Parents of 17 (65%) students in modified quarantine and 80 (40%) in standard home quarantine reported low or neutral levels of stress in their children. Parents of students in standard home quarantine described greater stress, negative impacts to family functioning, and interruptions to educational opportunities for students.

Conclusions
Students in modified quarantine reported lower adherence to quarantine recommendations but lower daily impact and stressors than those in standard home quarantine. Because in-school transmission of SARS-CoV-2 has been shown to be low when layered prevention strategies are in place regardless of the use of modified or standard home quarantine, this modified quarantine approach provides a reasonable option for balancing the needs of students and families with SARS-CoV-2 prevention measures.
Characteristics of salivary telomere length shortening in preterm infants
Authors: Schneper Lisa M. , Drake Amanda J. , Dunstan Taylor , Kotenko Iulia , Notterman Daniel A. , Piyasena Chinthika 
Published: January 2023

Objective
To examine the association between gestational age, telomere length (TL) and rate of shortening in newborns.

Study design
Genomic DNA was isolated from buccal samples of 39 term infants at birth and one year and 32 preterm infants at birth, term-adjusted age (40 weeks post-conception) and age one-year corrected for gestational duration. Telomere length was measured by quantitative real-time PCR. Demographic and clinical data were collected during clinic or research visits and from hospital records. Socioeconomic status was estimated using the deprivation category (DEPCAT) scores derived from the Carstairs score of the subject’s postal code.

Results
At birth, preterm infants had longer telomeres than infants born at term. However, there was no difference in telomere length between preterm infants and term infants at one year of age, implying that the rate of telomere shortening was greater in pre-term than term infants. Interestingly, TL at age 40 weeks post-conception in preterm infants was significantly longer than term infant TL at birth, suggesting that time since conception is not the only factor that affects rate of shortening. Several factors, including sex, fetal growth restriction, maternal age, maternal booking body mass index (BMI), mother education level and DEPCAT score, also differed between the preterm and term groups.

Conclusions
Preterm infants have longer telomeres than term infants at birth. In the studied cohort, the rate of telomere shortening was greater in the premature group compared with the term infants. This finding agrees with previous studies using cord blood, suggesting that the longer TL in premature infants detected at birth do not persist and demonstrating that use of saliva DNA is acceptable for studies of telomere dynamics in infants. However, that the TL at age 40 weeks post-conception in preterm is longer than term infants at birth suggests that biological factors other than time since conception also affect rate of shortening.
The impact of age on outcomes of breast cancer in different hormone receptor and HER2 groups
Authors: Zheng Hongjuan , Ge Chenyang , Lin Haiping , Zhou Shishi , Tang Wanfen , Wang Qinghua , Zhang Xia , Jin Xiayun , Xu Xifeng , Du Jinlin , Fu Jianfei 
Published: January 2023

Objective
The aim of the current study was to explore the association between age and outcomes in breast cancer.

Methods
Patients during 2010–2015 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Overall survival (OS) and breast cancer-specific death (BCSD) were taken as endpoints. The restrict cubic spline graph (RCS) was used to explore the relationship between age and outcomes in patients, and the cumulative incidence of BCSD and non-BCSD was calculated using the Gray method. Age-specific gene expression profiles were studied using RNA sequence data from the Cancer Genome Atlas (TCGA) database to explore whether there were young age-related gene or gene sets.

Results
A total of 142,755 patients with breast cancer were included. The hazard ratio (HR) of OS for Patients with stage I-III breast cancer was roughly stable before 53 years old and increased significantly after that, and the HR of BCSD for these patients showed a U-shaped distribution when plotted against age, with patients younger than 50 years and patients older than 70 years experiencing the worst survival. Further stratified analysis according to molecular subtype revealed that the U-shaped distribution of the HR of BCSD with was only found in the Hormone receptor-positive/HER2-negative (HoR+/HER2-) subgroup. The cumulative incidence plots showed that young age was associated with worse BCSD in the breast cancer patients with stage I-III and HoR+/HER2- subgroup. In stage IV breast cancer, there was a linearity of the relationship between poor OS and increasing age. We failed to find any differentially expressed age-specific genes between 20–40 years and 41–60 years groups in 258 patients with stage I-III and HoR+/HER2- subtype.

Conclusion
Young age could predict worse BCSD of patient with stage I-III and HoR+/HER2- breast cancer. The escalating therapy was recommended to young age breast cancer with stage I-III and HoR+/HER2- subtype.
Birth order and sickness absence: Register-based evidence from Finland
Authors: Reini Kaarina , Saarela Jan 
Published: January 2023

Background
In working ages, sickness absence is strongly related to persons’ health condition. We studied how birth order was associated with receipt of sickness allowance, distinguishing between mental disorders, musculoskeletal disorders and injuries.

Methods
A follow-up study based on the entire Finnish population was conducted for sibling groups born 1969–1982, in which each sibling was observed from age 35 years in the period 2004–2018. Focus was on within-family variation in first-time sickness allowance receipt.

Results
Results of stratified Cox regressions revealed that each increase in birth order was associated with a slightly higher risk of sickness absence from any cause. For mental disorders, associations were stronger; the hazard ratio as compared to first borns was 1.03 (95% CI: 0.98–1.08) of second borns, 1.10 (0.99–1.22) of third borns, and 1.52 (1.25–1.85) of fourth or higher borns. Corresponding numbers for musculoskeletal disorders were 1.12 (1.07–1.17), 1.19 (1.09–1.30) and 1.15 (0.96–1.38), and for injuries 1.06 (1.01–1.12), 1.09 (1.21–1.14) and 0.96 (0.77–1.20), respectively.

Conclusions
Birth order effects were generally stronger for women than men, and to some extent influenced by educational level, occupation, income, and family composition. Possible latent mechanisms behind the associations may relate to within-family dynamics at childhood.
Nonspiking Interneurons in theDrosophilaAntennal Lobe Exhibit Spatially Restricted Activity
Authors: Schenk Jonathan E. , Gaudry Quentin 
Published: January 2023

AbstractInhibitory interneurons are important for neuronal circuit function. They regulate sensory inputs and enhance output discriminability (Olsen and Wilson, 2008; Root et al., 2008; Olsen et al., 2010). Often, the identities of interneurons can be determined by location and morphology, which can have implications for their functions (Wachowiak and Shipley, 2006). While most interneurons fire traditional action potentials, many are nonspiking. These can be seen in insect olfaction (Laurent and Davidowitz, 1994; Husch et al., 2009; Tabuchi et al., 2015) and the vertebrate retina (Gleason et al., 1993). Here, we present the novel observation of nonspiking inhibitory interneurons in the antennal lobe (AL) of the adult fruit fly,Drosophila melanogaster. These neurons have a morphology where they innervate a patchwork of glomeruli. We used electrophysiology to determine whether their nonspiking characteristic is because of a lack of sodium current. We then used immunohistochemsitry andin situhybridization to show this is likely achieved through translational regulation of the voltage-gated sodium channel gene,para. Usingin vivocalcium imaging, we explored how these cells respond to odors, finding regional isolation in their responses’ spatial patterns. Further, their response patterns were dependent on both odor identity and concentration. Thus, we surmise these neurons are electrotonically compartmentalized such that activation of the neurites in one region does not propagate across the whole antennal lobe. We propose these neurons may be the source of intraglomerular inhibition in the AL and may contribute to regulation of spontaneous activity within glomeruli.
Opponent Learning with Different Representations in the Cortico-Basal Ganglia Circuits
Authors: Morita Kenji , Shimomura Kanji , Kawaguchi Yasuo 
Published: January 2023

AbstractThe direct and indirect pathways of the basal ganglia (BG) have been suggested to learn mainly from positive and negative feedbacks, respectively. Since these pathways unevenly receive inputs from different cortical neuron types and/or regions, they may preferentially use different state/action representations. We explored whether such a combined use of different representations, coupled with different learning rates from positive and negative reward prediction errors (RPEs), has computational benefits. We modeled animal as an agent equipped with two learning systems, each of which adopted individual representation (IR) or successor representation (SR) of states. With varying the combination of IR or SR and also the learning rates from positive and negative RPEs in each system, we examined how the agent performed in a dynamic reward navigation task. We found that combination of SR-based system learning mainly from positive RPEs and IR-based system learning mainly from negative RPEs could achieve a good performance in the task, as compared with other combinations. In such a combination of appetitive SR-based and aversive IR-based systems, both systems show activities of comparable magnitudes with opposite signs, consistent with the suggested profiles of the two BG pathways. Moreover, the architecture of such a combination provides a novel coherent explanation for the functional significance and underlying mechanism of diverse findings about the cortico-BG circuits. These results suggest that particularly combining different representations with appetitive and aversive learning could be an effective learning strategy in certain dynamic environments, and it might actually be implemented in the cortico-BG circuits.
RUMAH PUSPO BUDAYA NUSANTARA SEBAGAI PUSAT PENGEMBANGAN PENDIDIKAN KARAKTER MELALUI TARI NUSANTARA
Authors: Digdoyo Eko 
Published: January 2023

Abstrak: Tujuan penelitian adalah turut serta memublikasikan keragaman budaya nusantara, sebagai model penyelenggaraan pendidikan karakter bagi anak dan remaja berbasis budaya kearifan lokal. Kajian ini menunjukkan melalui pesanÂ moral seni tari perlu ditranformasikan dan diimplementasikan baik pada substansi maupun model pembelajaran yang mengakui dan menghormati keanekaragaman dan karakter budaya di masyarakat. Rumah Puspo Budaya Nusantara telah memiliki andil dalam mencerdasakan kehidupan bangsa melalui model pendidikan karakter anak dan remaja khususnya melalui ketrampilan seni tari nusantara. Hal ini terbukti melalui fasilitas yang dimiliki Rumah Puspo Budaya Nusantara senantiasa terbuka untuk umum bagi pegiat seni budaya. Eksistensi Rumah Puspo Budaya Nusantara melalui pendidikan informal maupun formal yang diselenggarakan dapat dikatakan mampu membentuk karakter anak dan remaja. Secara sadar maupun tidak sadar, pendidikan karakter mengacu pada; etika, moral, nilai, religius, budi pekerti, dan pendidikan karakter itu sendiri. Untuk itu, pendidikan baik formal, informal, dan non-formal pada hakekatnya memiliki dua tujuan, yaitu membantu manusia untuk menjadi cerdas dan pintar (smart), dan membantu menjadi manusia yang baik (good).Â
Rehabilitación estructural de conjuntos históricos
Authors: Maya-Miranda Enrique 
Published: January 2023

La actual política de recuperación de nuestros viejos Centros Históricos a partir de su Rehabilitación Integrada permite un cambio de escala de las intervenciones, desde la propia del edificio a la del conjunto en que se actúa. Cada construcción deja de entenderse como elemento individual y se constituye en parte de un todo que sólo tiene sentido si se considera como tal unidad. Por ello, deben entenderse estos conjuntos edificados como realidad construida, en la que se programen las intervenciones, se optimicen los medios disponibles, se eviten actuaciones parciales y poco meditadas. En este sentido, resulta de interés, que en cada Centro Histórico se definan sus propias líneas de intervención, profundizando en el conocimiento de sus tipologías edificatorias y de sus sistemas constructivos, fomentando a su vez la recuperación de las técnicas y sistemas precisas para ello.
En el presente artículo se pretende aportar una aproximación al entendimiento estructural del edificio considerado como pieza de la estructura urbana en que se implanta, a partir del conocimiento del parcelario y de la tipología edificatoria.
The ecumenical aspect of the justification of the sinner
Authors: Medwid Wojciech 
Published: January 2023

The aim of this article is to discuss the ecumenical aspect of justification. Martin Luther was of the opinion that the road to justification was only through faith and grace, expressed by the principle simul iustus et peccator. The Council of Trent emphasized that justification is not only the remission of sins but is also sanctification. Catholic-Lutheran ecumenical dialogue formally began after the Second Vatican Council, which resulted in a consensus regarding the basic truths of the doctrine of justification and likewise looked at the person of Martin Luther, his demands, and the reformation.
Patriarcado y amor. La teoría política de Anna G. Jónasdóttir
Authors: Grajales Usuga Martha Elena 
Published: January 2023

La tesis de la politóloga islandesa Anna Jónasdóttir sobre el patriarcado es que en la actualidad este se fundamenta en la explotación del amor de las mujeres por parte de sus compañeros sentimentales. El propósito de este artículo es evaluar esta influyente teoría feminista y sus alcances para explicar la persistencia del patriarcado en América Latina. El análisis sigue tres pasos: primero, se exponen las tesis centrales de la autora sobre el patriarcado y su vínculo con el amor; segundo, se señalan las limitaciones de la propuesta para comprender el patriarcado en Latinoamérica, donde las mujeres son marginalizadas a causa del amor, pero también debido a la desigualdad social, la violencia y las prácticas coloniales; finalmente, se destacan los aportes de la teoría para esclarecer males muy generalizados entre las mujeres latinoamericanas como la violencia de pareja y la misoginia en general. La principal conclusión es que, a pesar de ciertas limitaciones argumentativas y metodológicas, la teoría de Jónasdóttir contribuye a esclarecer algunos fenómenos de opresión sufridos por las mujeres de nuestra región.
El análisis sigue tres pasos: primero, se exponen las tesis centrales de la autora sobre el patriarcado y su vínculo con el amor. Segundo, se señalan las limitaciones de la propuesta para comprender el patriarcado en Latinoamérica, donde las mujeres son marginalizadas a causa del amor, pero también debido a la desigualdad social, la violencia y las prácticas coloniales. Finalmente, se destacan los aportes de la teoría para esclarecer males muy generalizados entre las mujeres latinoamericanas como la violencia de pareja y la misoginia en general.
FPGA Implementation of Double Precision Floating Point Multiplier
Authors: Abdullah Mohd. , Chourasia Bharti 
Published: January 2023

High speed computation is the need of today’s generation of Processors. To accomplish this major task, many functions are implemented inside the hardware of the processor rather than having software computing the same task. Majority of the operations which the processor executes are Arithmetic operations which are widely used in many applications that require heavy mathematical operations such as scientific calculations, image and signal processing. Especially in the field of signal processing, multiplication division operation is widely used in many applications. The major issue with these operations in hardware is that much iteration is required which results in slow operation while fast algorithms require complex computations within each cycle. The result of a Division operation results in a either in Quotient and Remainder or a Floating point number which is the major reason to make it more complex than Multiplication operation.