bluuebunny/crossref_metadata_2025_split huggingface dataset:
Y2O3NPs induce selective cytotoxicity, genomic instability, oxidative stress and ROS mediated mitochondrial apoptosis in human epidermoid skin A-431 Cancer cells
Authors: Mohamed Hanan RH , Hemdan Shrouk H.A , El-Sherif Ahmed A. 
Published: January 2025

AbstractYttrium oxide nanoparticles (Y2O3NPs) have emerged as a promising avenue for cancer therapy, primarily due to their distinctive properties that facilitate selective targeting of cancer cells. Despite their potential, the therapeutic effects of Y2O3NPs on human epidermoid skin cancer remain largely unexplored. This study was thus conducted to investigate the impact of Y2O3NPs on both human skin normal and cancer cells, with an emphasis on assessing their cytotoxicity, genotoxicity, and the mechanisms underlying these effects. Cell viability and apoptosis induction were assessed using the Sulforhodamine B and chromatin diffusion assay, respectively. Reactive oxygen species (ROS) level, mitochondrial membrane potential integrity, oxidative stress markers and expression level of apoptotic and mitochondrial genes were also estimated. Our findings highlight the selective and significant cytotoxicity of Y2O3NPs against human epidermoid A-431 cancer cells. Notably, exposure to five Y2O3NPs concentrations (0.1, 1, 10, 100 and 1000 µg/ml) resulted in a high concentration-dependent reduction in cell viability and a corresponding increase in cell death observed 72 h post-treatment specifically in A-431 cancer cells, while normal skin fibroblast (HSF) cells exhibited minimal toxicity. When A-431 cancer cells were treated with the half-maximal inhibitory concentration (IC50) of Y2O3NPs for 72 h, a significant increase in ROS generation was noted. This led to oxidative stress, along with severe damage to genomic DNA and mitochondrial membrane potential, triggering substantial apoptosis. Furthermore, a concurrent significant upregulation of apoptotic p53 and mitochondrial ND3 genes was observed, coupled with a notable decrease in the anti-apoptotic Bcl2 gene expression.Overall, Y2O3NPs demonstrate considerable promise as a therapeutic agent for skin epidermoid cancer due to their ability to selectively target and induce cytotoxic effects in A-431 cancer cells, all while causing minimal harm to normal HSF cells. This selective cytotoxicity appears to be associated with Y2O3NPs’ ability to induce excessive ROS production and subsequent oxidative stress, leading to significant genomic DNA fragmentation, loss of mitochondrial permeability, and alterations in apoptotic and mitochondrial genes’ expression, ultimately promoting apoptosis in A-431 cancer cells. These findings establish a foundation for further research into the utilization of Y2O3NPs in targeted cancer therapies and underscore the necessity for ongoing investigation into their safety and efficacy in clinical applications.
Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression
Authors: Nshanian Michael , Gruber Joshua J. , Geller Benjamin S. , Chleilat Faye , Lancaster Samuel M. , White Shannon M. , Alexandrova Ludmila , Camarillo Jeannie M. , Kelleher Neil L. , Zhao Yingming , Snyder Michael P. 
Published: January 2025

Abstract
The short-chain fatty acids (SCFAs) propionate and butyrate have beneficial health effects, are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks. To better understand the function of these modifications, we used chromatin immunoprecipitation followed by sequencing to map the genome-wide location of four short-chain acyl histone marks, H3K18pr, H3K18bu, H4K12pr and H4K12bu, in treated and untreated colorectal cancer (CRC) and normal cells as well as in mouse intestines in vivo. We correlate these marks with open chromatin regions and gene expression to access the function of the target regions. Our data demonstrate that propionate and butyrate bind and act as promoters of genes involved in growth, differentiation and ion transport. We propose a mechanism involving direct modification of specific genomic regions by SCFAs resulting in increased chromatin accessibility and, in the case of butyrate, opposing effects on the proliferation of normal versus CRC cells.
A reform of value-added taxes on foods can have health, environmental and economic benefits in Europe
Authors: Springmann Marco , Dinivitzer Eugenia , Freund Florian , Jensen Jørgen Dejgård , Bouyssou Clara G. 
Published: January 2025

Abstract
Fiscal policies can provide important incentives for encouraging the dietary changes needed to achieve global policy targets. Across Europe, the foods relevant to health and the environment often incur reduced but non-zero value-added tax (VAT) rates at about half the maximum rates, which allows for providing both incentives and disincentives. Integrating economic, health and environmental modelling, we show that reforming VAT rates on foods, including increasing rates on meat and dairy, and reducing VAT rates on fruits and vegetables can improve diets and result in health, environmental and economic benefits in most European countries. The health improvements were primarily driven by reductions in VAT rates on fruits and vegetables, whereas most of the environmental and revenue benefits were driven by increased rates on meat and dairy. Our findings suggest that differentiating VAT rates based on health and environmental considerations can support changes towards healthier and more sustainable diets in Europe.
A compact group lens modeled with GIGA-Lens: Enhanced inference for complex systems
Authors: Urcelay F. , Jullo E. , Barrientos L. F. , Huang X. , Hernandez J. 
Published: January 2025

Context. In the era of large-scale astronomical surveys, the fast modeling of strong lens systems has become increasingly vital. While significant progress has been made for galaxy-scale lenses, the development of automated methods for modeling larger systems, such as groups and clusters, is not as extensive.
Aims. Our study aims to extend the capabilities of the GIGA-Lens code, enhancing its efficiency in modeling multi-galaxy strong lens systems. We focus on demonstrating the potential of GPU-accelerated Bayesian inference in handling complex lensing scenarios with a high number of free parameters.
Methods. We employed an improved inference approach that combines image position and pixelated data with an annealing sampling technique to obtain the posterior distribution of complex models. This method allowed us to overcome the challenges of limited prior information, a high number of parameters, and memory usage. We validated our process through the analysis of the compact group lens system DES J0248-3955 and we present the relevant VLT/X-shooter spectra.
Results. We measured a redshift of z = 0.69 ± 0.04 for the group, and z = 1.2722 ± 0.0005 for one of the extended arcs. Our enhanced method successfully constrained a lens model with 29 free parameters and lax priors in a remarkably short time. The mass of the lens is well described by a single dark-matter halo with a velocity dispersion of σv = (690 ± 30) km s−1. The model predicts the presence of a second source at the same redshift and a third source at approximately z ~ 2.7.
Conclusions. Our study demonstrates the effectiveness of our lens modeling technique for dealing with a complex system in a short time using ground-based data. This presents a considerable prospect within the context of large surveys, such as LSST, in the future.
Building Credibility with Comprehensive Citation Practices
Authors: Subramanian Pavithra , Soundararajan Raghuraman , Makol Jyotsna 
Published: January 2025

AbstractHonoring those who paved the way and paving the way for others is an old saying and practice that emphasizes the importance of acknowledging the contributions of others while also guiding and mentoring those who follow in your footsteps. In academic and scientific writings, citations are very important for maintaining the integrity, credibility, and progression of scientific knowledge. This article examines the significance of citations, their various types and methods, and the different styles used. By focusing on best practices and common errors, this article aims to guide researchers in effectively incorporating citations to enhance their work's visibility and impact. It analyses the different types of citations, including direct quotes, paraphrases, and summaries, and discusses the major citation systems such as the Vancouver and Harvard styles. The article also examines the common errors in citation practices and offers guidelines for accurate referencing. It also reviews various reference management software that facilitate to organize and automate the citation process. The impact of citations on bibliometric measures such as impact factor, H index, CiteScore, etc., which assess the influence and productivity of research, is also discussed. Further, the article briefly delves into the utility of artificial intelligence in citation management and future directions in citation practices. The goal of this article is to elevate the quality and credibility of academic publications in the area of medicine by focusing on the principles and methods of effective citation.
Writing for Clarity: A Concise Guide for Scientific Writing and Tips for Selecting a Journal
Authors: Apoorv Thittayil Suresh 
Published: January 2025

AbstractScientific writing is very important for writing research articles or commentaries. This article provides practical tips for researchers and clinicians to write well. Empowered researchers would be able to disseminate their research findings, help change the clinical practice, and advance public health.
Historiography of Scientific Publishing across Cultures and Disciplines
Authors: Hosur Bharat , Tripathi Manjul , Vyas Sameer , Shaikh Sikandar , Ahuja Chirag K. 
Published: January 2025

AbstractHistoriography is a vital perspective of our scientific literature that charts the evolution of scientific publishing, from its early origins to the present status. The key transformations including the shift from a limited self-published legacy to specialized and professional peer-reviewed journals, the impact of technological advancements, and the emergence of new profitable business models are learning points for the future course and couture. Science is pursued and persevered by real humans in social and cultural contexts and not in isolation of laboratories or clinics. Survival of the impartial pure scientific bent of mind and its translation into tangible works has not been easy through the turmoil of various forms of force majeure. The lack of gender parity and even its divergence in some ways was palpable in the discourse of scientific research. Despite that, when provided with a common platform with comparable impact factors and rates of publications, gender inequality seems to vanish and equivalence in academia is discernible. The roles of authors, publishers, and readers have also evolved chronologically, adapting to the influence of cultural and disciplinary factors through the ages. The challenges of predatory publishing, open access, plagiarism, and data capitalization are also growing alongside. Ultimately, understanding the historical context and persistence of the predecessors in the course of scientific publishing can enhance modern scientific research and communication.
Hip Abductor Deficiency after Total Hip Arthroplasty: Diagnostic and Therapeutic Methods
Authors: Krüger David Richard , Heller Karl-Dieter 
Published: January 2025

AbstractAbductor deficiency after total hip arthroplasty is a severe complication with functional limitations and a significant reduction in the patient's quality of life. Common causes are degenerative ruptures or approach-related iatrogenic damage to the gluteus medius and minimus muscle and the inferior gluteal nerve, fractures of the greater trochanter and incorrect reconstruction of leg length and femoroacetabular offset. With a standardised diagnosis consisting of a clinical examination, conventional X-ray and MRI, the causes of the functional problems can often be reliably determined. Therapy of abductor deficiency is challenging for both patients and physicians and is often tedious. However, with a clear diagnostic and therapeutic algorithm and straightforward patient education, good treatment results can be achieved even in this challenging condition. Conservative therapy with eccentric stretching and muscle strengthening are the basis of the treatment. In cases of progression of complaints despite intensive conservative treatment, various anatomical and extra-anatomical surgical reconstruction methods are available to relieve pain and improve function. Anatomical reconstruction of the gluteal tendon insertion is an option in cases of low-grade fatty infiltration and moderate retraction of the gluteal muscles. In situations with advanced degenerative changes in the gluteus medius and minimus muscles and an intact gluteus maximus muscle, transfer of the anterior portion of the gluteus maximus according to Whiteside is an option. For high-grade defects of the soft tissue, there is also the option of an isolated or combined transfer of the vastus lateralis muscle.
Titanium – a Cementable Material for Endoarthroplasty
Authors: Jaenisch Max , Wirtz Dieter Christian 
Published: January 2025

AbstractAs materials for arthroplasty, titanium alloys exhibit the following advantages over conventional steel, cobalt chromium or chromium nickel alloys – good fatigue strength, excellent biocompatibility, low modulus of elasticity, and high corrosion resistance. The previous worse clinical outcome was most likely caused by crevice corrosion and led to reduced use. To warrant safe use, the design should be optimised (sufficient proximal diameter, proximal collar), in order to reduce unwanted deformation in the proximal part of the prosthesis. Additionally, a rough surface (Ra > 2.5 μm) should not be used. Further research in surface treatments (e. g. silicate-silane) could facilitate additional improvement.
Local Administration of Antibiotics in Orthopedics and Traumatology
Authors: Gramlich Yves , Schnetz Matthias , Hoffmann Reinhard 
Published: January 2025

Abstract2022 marks the 50th anniversary of the development of the antibiotic loaded PMMA chain. The loading of bone cements with antibiotics was a major advance in the treatment of musculoskeletal infections and is still a proven standard today. The research and use of novel antibiotic carriers continues to be an important part of research in the context of musculoskeletal infections. The article provides an overview of the various local antibiotics available and their specifics. In addition, current adapted treatment concepts are discussed.
Analytical derivative approaches for vibro-polaritonic structures and properties. I. Formalism and implementation
Authors: Huang Xunkun , Liang WanZhen 
Published: January 2025

Vibro-polaritons are hybrid light–matter states that arise from the strong coupling between the molecular vibrational transitions and the photons in an optical cavity. Developing theoretical and computational methods to describe and predict the unique properties of vibro-polaritons is of great significance for guiding the design of new materials and experiments. Here, we present the ab initio cavity Born–Oppenheimer density functional theory (CBO-DFT) and formulate the analytic energy gradient and Hessian as well as the nuclear and photonic derivatives of dipole and polarizability within the framework of CBO-DFT to efficiently calculate the harmonic vibrational frequencies, infrared absorption, and Raman scattering spectra of vibro-polaritons as well as to explore the critical points on the cavity potential energy surface. The implementation of analytic derivatives into the electronic structure package is validated by a comparison with the finite-difference method and with other reported computational results. By adopting appropriate exchange–correlation functionals, CBO-DFT can better describe the structure and properties of molecules in the cavity than CBO-Hartree–Fock method. It is expected that CBO-DFT is a useful tool for studying the polaritonic structures and properties.
Cluster perturbation theory. XI. Excitation-energy series using a variational excitation-energy function
Authors: Hillers-Bendtsen Andreas Erbs , Johansen Magnus Bukhave , Juncker von Buchwald Theo , Mikkelsen Kurt V. , Olsen Jeppe , Jørgensen Poul , Helgaker Trygve 
Published: January 2025

Traditionally, excitation energies in coupled-cluster (CC) theory have been calculated by solving the CC Jacobian eigenvalue equation. However, based on our recent work [Jørgensen et al., Sci. Adv. 10, eadn3454 (2024)], we propose a reformulation of the calculation of excitation energies where excitation energies are determined as a conventional molecular property. To this end, we introduce an excitation-energy function that depends on the CC Jacobian and the right and left eigenvectors for the Jacobian eigenvalue problem. This excitation-energy function is variational with respect to the right and left eigenvectors but not with respect to the cluster amplitudes. Instead, the cluster amplitudes satisfy the cluster-amplitude equations, and we set up an excitation-energy Lagrangian by adding to the excitation-energy function the cluster-amplitude equations with an undetermined multiplier for each cluster-amplitude constraint. The excitation-energy Lagrangian is variational in all its parameters. Based on the variational property of the Lagrangian, we have determined two quadratically convergent excitation-energy series: the total-order cluster-perturbation (tCP) and variational cluster-perturbation (vCP) excitation-energy series. Calculations of the excitation energies of three small molecules have shown that the vCP series is to be preferred over the tCP series. The test calculations have been carried out for CPS(D) expansions [targeting the CC singles-and-doubles (CCSD) wave function from the CC singles wave function] and the CPSD(T) expansion [targeting the CC singles-doubles-triples (CCSDT) wave function from the CCSD wave function]. For the S(D) and SD(T) orbital excitation space calculations, we obtain in the second vCP iteration excitation energies with a mean deviation from CCSD excitation energies of about 0.04 eV for the S(D) orbital spaces, and for the SD(T) orbital space calculation, we obtain a mean deviation from the CCSDT excitation energies of 0.001 eV.
Classical (“ontological”) dual states in quantum theory and the minimal group representation Hilbert space
Authors: Cirilo-Lombardo Diego J. , Sanchez Norma G. 
Published: January 2025

We investigate the classical aspects of quantum theory and under which description quantum theory does appear classical. Although such descriptions or variables are known as “ontological” or “hidden,” they are not hidden at all but are dual classical states (in the sense of the general classical–quantum duality of nature). We analyze and interpret the dynamical scenario in an inherent quantum structure: (i) We show that the use of the known φ states in the circle [F. London, Z. Phys. 37, 915 (1926) and G. ’t Hooft, “The hidden ontological variable in quantum harmonic oscillators,” arXiv 2407.18153 (2024)] takes a true dimension only when the system is subjected to the minimal group representation action of the metaplectic group Mp(n). The Mp(n) Hermitian structure fully covers the symplectic Sp(n) group and, in certain cases, OSp(n). (ii) We compare the circle φ states and the cylinder ξ states in configuration space with the two sectors of the full Mp(2) Hilbert space corresponding to the even and oddn harmonic oscillators and their total sum. (iii) We compute the projections of the Mp(2) states on the circle φ and cylinder ξ states. The known London circle states are not normalizable. We compute here the general coset coherent states α,φ in the circle, with α being the coherent complex parameter. It allows full normalizability of the complete set of the circle states. (iv) The London states (ontological in ’t Hooft’s description) completelyclassicalize the inherent quantum structure only under the action of the Mp(n) minimal group representation. (v) For the coherent states in the cylinder (configuration space), all functions are analytic in the disk z=ωe−iφ&lt;1. For the general coset coherent states α,φ in the circle, the complex variable is z′=ze−iα*/2: The analytic function is modified by the complex phase (φ − α*/2). (vi) The analyticity z′=ze−Imα/2&lt;1 occurs when Im α ≠ 0 because of normalizability and Im α &gt; 0 because of the identity condition. The circle topology induced by the α,φ coset coherent state also modifies the ratio of the disk due to the displacement by the coset. (vii) For the coset coherent cylinder states in configuration space, the classicalization is stronger due to screening exponential factors e−2n2, e−(2n+1/2), and e−(2n+1/2)2 for large n arising in the Mp(2) projections on them. The generalized Wigner function shows a bell-shaped distribution and stronger classicalization than the square norm functions. The application of the minimal group representation immediately classicalizes the system, with Mp(2) emerging as the group of the classical–quantum duality symmetry.
Construction Grammar, multimodal communication, and design
features of language
Authors: Verhagen Arie 
Published: January 2025

Abstract
The issue of the constructional status of a pattern of multimodal communication involves the
necessity to determine the position of the pattern on several distinct dimensions. Does it use the auditory or the
visual channel, or both? To what degree is it entrenched, conventional, or both? Does it exploit depictive or
descriptive techniques of communication, or both? An answer to one of these questions does not determine the answers
in the other dimensions; they correlate only partly. As a result, there can be no single combination of values on the
dimensions such that it determines the constructional status of the pattern (yes or no). But while the correlations
are only partial, particular values on some dimensions are differentially ‘attracted’ to certain values on another one
(e.g. speech seems to be more attracted to conventionality than vision). In this paper, I demonstrate these points and
explore some conceptual and causal differences and connections between these dimensions, for the purpose of enhancing
conceptual clarity and distinguishing terminological from truly empirical issues.
Utterance comprehension in spontaneous speech
Authors: Machač Pavel , Fried Mirjam 
Published: January 2025

Abstract
The nature of spontaneous speech raises questions concerning the relationship between phonetic
reductions and unimpaired comprehension of an utterance. The results of a pilot experiment based on individual
production and community perception in Czech spontaneous conversations suggest that there is detectable patterning in
how and where speakers tend to save articulatory effort without compromising listeners’ comprehension. We identify
several non-phonetic factors that appear to motivate the reductions and their position in utterances: information
structure, semantic content, morphosyntactic redundancy, and syntactic organization. Based on our findings, we suggest
that constructional representations should incorporate the ways in which grammatical organization and phonetics may
‘fill in’ for each other in the course of the collaborative interpretive effort during spontaneous interaction.