bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leukemic phase as the initial presentation of ALK‐positive anaplastic large‐cell lymphoma complicated by lactic acidosis
Authors: Nakagawa Noriharu , Yamazaki Masahide 
Published: February 2023

AbstractThe leukemic phase of ALK‐positive anaplastic large cell lymphoma (ALCL) is reported to have a poor prognosis. We, herein, report a rare case of the common type of ALK‐positive ALCL complicated by lactic acidosis.
A case of Candida parapsilosis bioprosthetic valve endocarditis
Authors: Sakakibara Kenji , Nakajima Hiroyuki 
Published: February 2023

AbstractFungal bioprosthetic valve endocarditis is regarded as a rare, fatal disease. Severe aortic valve stenosis due to vegetation in bioprosthetic valves was also rare. Because biofilm formation is a factor related to persistent infection, the best outcomes for endocarditis are achieved in patients treated surgically with concomitant antifungal medicine.
Total rhinectomy with prosthesis placement as a treatment for moderately differentiated squamous cell carcinoma of the nose
Authors: Rivera Martínez César Gamaliel , Hernández Abarca Edgar , Busto Ruano José Pablo , Martínez Quincosa Mayrelle , Priego Blancas Raymundo Benjamín , López Chavira Adelaido , Romo Magdaleno Jorge Alberto 
Published: February 2023

AbstractSquamous cell carcinoma is one of the most common head and neck types of skin cancer. This main objective of this paper is to present a case of a patient who had a moderately differentiated squamous cell carcinoma of the nose and whose tumor had an aggressive growth.
Racial inequities in the quality of surgical care among Medicare beneficiaries with localized prostate cancer
Authors: Nyame Yaw A. , Holt Sarah K. , Etzioni Ruth D. , Gore John L. 
Published: February 2023

AbstractBackgroundUS Black men are twice as likely to die from prostate cancer as men of other races. Lower quality care may contribute to this higher death rate.MethodsSociodemographic and clinical data were obtained for men in Surveillance, Epidemiology, and End Results‐Medicare diagnosed with clinically localized prostate cancer (cT1‐4N0/xM0/x) and managed primarily by radical prostatectomy (2005–2015). Surgical volume was determined for facility and surgeon. Relationships between race, surgeon and/or facility volume, and characteristics of treating facility with survival (all‐cause and cancer‐specific) were assessed using multivariable Cox regression and competing risk analysis.ResultsBlack men represented 6.7% (n = 2123) of 31,478 cohort. They were younger at diagnosis, had longer time from diagnosis to surgery, lower socioeconomic status, higher prostate‐specific antigen (PSA), and higher comorbid status compared with men of other races (p < .001). They were less likely to receive care from a surgeon or facility in the top volume percentile (p < .001); less likely to receive surgical care at a National Cancer Institute‐designated cancer center and more likely seen at a minority‐serving hospital; and less likely to travel ≥50 miles for surgical care. On multivariable analysis stratified by surgical volume, Black men receiving care from a surgeon or facility with lower volumes demonstrated increased risk of prostate cancer mortality (hazard ratio, 1.61; 95% confidence interval, 1.01–2.69) adjusting for age, clinical stage, PSA, and comorbidity index.ConclusionsBlack Medicare beneficiaries with prostate cancer more commonly receive care from surgeons and facilities with lower volumes, likely affecting surgical quality and outcomes. Access to high‐quality prostate cancer care may reduce racial inequities in disease outcomes, even among insured men.Plain language summary

Black men are twice as likely to die of prostate cancer than other US men.

Lower quality care may contribute to higher rates of prostate cancer death.

We used surgical volume to evaluate the relationship between race and quality of care.

Black Medicare beneficiaries with prostate cancer more commonly received care from surgeons and facilities with lower volumes, correlating with a higher risk of prostate cancer death and indicating scarce resources for care.

Access to high‐quality prostate cancer care eases disparities in disease outcomes.

Patient‐centered interventions that increase access to high‐quality care for Black men with prostate cancer are needed.
Characterization of 3D printed biodegradable piezoelectric scaffolds for bone regeneration
Authors: Karanth Divakar , Puleo David , Dawson Dolph , Holliday L. S. , Sharab Lina 
Published: February 2023

AbstractObjectiveThe primary objective of this research was to develop a poly(l‐lactic acid) (PLLA) scaffold and evaluate critical characteristics essential for its biologic use as a craniofacial implant.Materials and MethodsPLLA scaffolds were designed and fabricated using fused deposition modeling technology. The surface morphology and microarchitecture were analyzed using scanning electron microscopy (SEM) and microCT, respectively. Crystallography, compressive modulus, and the piezoelectric potential generated upon mechanical distortion were characterized. Hydrolytic degradation was studied. MG63 osteoblast‐like cell proliferation and morphology were assessed.ResultsThe porosity of the scaffolds was 73%, with an average pore size of 450 µm and an average scaffold fiber thickness of 130 µm. The average compressive modulus was 244 MPa, and the scaffolds generated an electric potential of 25 mV upon cyclic/repeated loading. The crystallinity reduced from 27.5% to 13.9% during the 3D printing process. The hydrolytic degradation was minimal during a 12‐week period. Osteoblast‐like cells did not attach to the uncoated scaffold but attached well after coating the scaffold with fibrinogen. They then proliferated to cover the complete scaffold by Day 14.ConclusionThe PLLA scaffolds were designed and printed, proving the feasibility of 3D printing as a method of fabricating PLLA scaffolds. The elastic modulus was comparable to that of trabecular bone, and the piezoelectric properties of the PLLA were retained after 3D printing. The scaffolds were cytocompatible. These 3D‐printed PLLA scaffolds showed promising properties akin to the natural bone, and they warrant further investigation for bone regeneration.
Comparison of digital and visual tooth shade selection
Authors: Abu‐Hossin Sabrin , Onbasi Yonca , Berger Lara , Troll Florian , Adler Werner , Wichmann Manfred , Matta Ragai‐Edward 
Published: February 2023

AbstractObjectiveIn dental restorations, color determination is very important for achieving esthetic results. The aim of this study was to compare visual shade selection using digital methods and to assess the repeatability of the utilized intraoral scanners.Materials and methodsIn 31 probands, tooth color was determined on teeth 11, 13, and 16. Shade selection was performed visually by a dentist and digitally using Trios 3 and Cerec Omnicam. Three measurements were performed to determine the repeatability of intraoral scanners. Fleiss' κ was used for statistical evaluation of the repeatability and Cohen's κ was used for comparison of methods.ResultsThe visual method showed only slight agreement with Trios 3 (Cohen's κ: 0.198) and Cerec Omnicam (Cohen's κ: 0.115). Moderate agreement was found between Trios 3 and Cerec Omnicam (Cohen's κ: 0.452). In terms of repeatability, Trios 3 scored higher overall than Cerec Omnicam (Fleiss' κ: 0.612 vs. 0.474).ConclusionIntraoral scanners can facilitate the workflow in clinical practice. They are a good supplement for color determination, but should additionally be confirmed by the visual method. Clinical significance: The use of digital instruments is increasingly being preferred over conventional treatments. Therefore, it is essential to continuously improve the accuracy of intraoral scanners for color selection in order to offer an alternative to visual methods.
Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection
Authors: Wu Xuejie , Xu Feng 
Published: February 2023

AbstractHepatitis B virus (HBV) infection is one of the most common causes of viral hepatitis worldwide. Patients with persistent HBV infection may suffer from liver cirrhosis, hepatocellular carcinoma or hepatic failure. In this review, we mainly discuss the immunotherapy for HBV infection. At present, drugs against HBV include oral nucleos(t)ide analogues and interferon. It is difficult to achieve the loss of hepatitis B surface antigen which is an ideal treatment endpoint in patients with chronic hepatitis B (CHB) using the currently recommended agents. There is a need for additional effective therapies among which immunotherapy may be a promising option. Dendritic cells (DCs) exert a key role in initiating the adaptive immune response that could determine the outcome of HBV infection. DC‐based immunotherapy has been explored in chronic HBV infection and shows some promising results. We conclude that DC‐based immunotherapy may be a potential therapeutic option for chronic HBV infection.
Unlabeled fluorescence ELISA using yellow emission carbon dots for the detection of Alicyclobacillus acidoterrestris in apple juice
Authors: Sun Yuhan , Yue Tianli , Yuan Yahong , Shi Yiheng 
Published: February 2023

AbstractJuice spoilage caused by Alicyclobacillus acidoterrestris has troubled the global manufacturers for many years. Most approaches have failed to detect this bacterium with desirable sensitivity and selectivity because of their inherent drawbacks. In this work, carbon dots (CDs) with bright fluorescence were prepared which can be quenched by the HRP‐catalyzed oxidation product of p‐phenylenediamine, via inner filter effect. Therefore, an unlabeled fluorescence ELISA strategy incorporating CDs as signal reporter was developed for the detection of A. acidoterrestris in apple juice. This approach showed excellent performance on target identification with enhanced specificity, achieving a limit of detection of 3.2 × 102 CFU/mL. It is expected that this method could provide a reliable way for timely identification of A. acidoterrestris, effectively warning against the emergence of juice spoilage incidence.
The study of single‐cell dynamics contributes to the evaluation of food‐derived antioxidant capacity
Authors: Xiang Xiong , Qing Yinglu , Li Shan , Kwame Amakye W. , Wang Min , Ren Jiaoyan 
Published: February 2023

AbstractExploring potential food‐derived bioactive substances that relieve oxidative stress is considered an important goal for antioxidant research. We first used the long‐pair electron index and orbital fingerprint to predict the molecular interactions in a range of polyphenols and polypeptides. We found Rutin and peptide PW5 had the highest LPE index values. Subsequently, by D‐galactose (D‐gal)‐induced oxidative NIH3T3 cell model, we proved both Rutin and PW5 could effectively protect cells against D‐gal‐induced damage, through enhancement in cell proliferation and reduction in β‐galactosidase activity. Although Rutin displayed better performance than PW5 in the oxidative stress model, we confirmed Rutin stimulated obvious changes in the morphology and motility of normal NIH3T3 cells based on the real‐time dynamic images. Taken together, combined computational and typical model experiment methods, proved useful in efficiently screening food‐derived antioxidants. Moreover, the analytical results of cell morphology and movement may provide novel insights for the safety evaluation of antioxidants.
Jitter‐sensitive data communication in emerging wireless networks
Authors: Sheikh Waseem 
Published: February 2023

AbstractJitter and time‐sensitive communications (TSC) will play an important role as part of the emerging wireless networks such as fifth‐generation (5G) and sixth‐generation (6G) cellular networks to enable applications including vehicle‐to‐everything (V2X), real‐time audio/video, real‐time industrial automation and control, and synchronized collaboration. TSC is characterized by stringent latency, jitter, and reliability requirements. This paper considers the problem of scheduling time‐sensitive data packets with stringent playout deadlines over a downlink multiple‐input multiple‐output (MIMO) channel, as part of the emerging wireless networks, to minimize the average jitter of a data session. Even though extensive research has been performed on MIMO technology, jitter and time‐sensitive data communication over a MIMO channel remains an under‐studied problem. In the proposed model, early or late arrival of the packets with respect to their playout deadlines incurs an early‐ or late‐arrival penalty, respectively. The proposed scheduling problem is proven to be NP‐hard and three computationally‐efficient scheduling heuristics are developed with varying performance and computational tradeoffs. These heuristics make packet scheduling decisions over the MIMO subchannels with the objective of minimizing the average jitter value of the data session. While making scheduling decisions, these heuristics intelligently take into consideration the playout deadlines and size of the packets, the time‐varying channel conditions, and the cost of the early or late arrival of the packets. The performance of these heuristics is evaluated from a design perspective through extensive simulations. The simulation results provide key insights into the relative performance tradeoffs among the three heuristics as a function of the various system parameters. This information could be utilized in intelligently allocating system resources to obtain the desired optimal system performance.
27‐hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia‐associated brain white matter changes
Authors: Alanko Vilma , Gaminde‐Blasco Adhara , Quintela‐López Tania , Loera‐Valencia Raúl , Solomon Alina , Björkhem Ingemar , Cedazo‐Minguez Angel , Maioli Silvia , Tabacaru Graziella , Latorre‐Leal María , Matute Carlos , Kivipelto Miia , Alberdi Elena , Sandebring‐Matton Anna 
Published: February 2023

AbstractOxidized cholesterol metabolite 27‐hydroxycholesterol (27‐OH) is a potential link between hypercholesterolemia and neurodegenerative diseases since unlike peripheral cholesterol, 27‐OH is transported across the blood–brain barrier. However, the effects of high 27‐OH levels on oligodendrocyte function remain unexplored. We hypothesize that during hypercholesterolemia 27‐OH may impact oligodendrocytes and myelin and thus contribute to the disconnection of neural networks in neurodegenerative diseases. To test this idea, we first investigated the effects of 27‐OH in cultured oligodendrocytes and found that it induces cell death of immature O4+/GalC+ oligodendrocytes along with stimulating differentiation of PDGFR+ oligodendrocyte progenitors (OPCs). Next, transgenic mice with increased systemic 27‐OH levels (Cyp27Tg) underwent behavioral testing and their brains were immunohistochemically stained and lysed for immunoblotting. Chronic exposure to 27‐OH in mice resulted in increased myelin basic protein (MBP) but not 2′,3′‐cyclic‐nucleotide 3′‐phosphodiesterase (CNPase) or myelin oligodendrocyte glycoprotein (MOG) levels in the corpus callosum and cerebral cortex. Intriguingly, we also found impairment of spatial learning suggesting that subtle changes in myelinated axons of vulnerable areas like the hippocampus caused by 27‐OH may contribute to impaired cognition. Finally, we found that 27‐OH levels in cerebrospinal fluid from memory clinic patients were associated with levels of the myelination regulating CNPase, independently of Alzheimer's disease markers. Thus, 27‐OH promotes OPC differentiation and is toxic to immature oligodendrocytes as well as it subtly alters myelin by targeting oligodendroglia. Taken together, these data indicate that hypercholesterolemia‐derived higher 27‐OH levels change the oligodendrocytic capacity for appropriate myelin remodeling which is a crucial factor in neurodegeneration and aging.
Identification of medication classes associated with intensive care unit readmissions
Authors: Meckel Jordan D. , Benanti Grace E. , Schomer Kendra J. , Adams Jason Y. , Parker Patricia L. 
Published: February 2023

AbstractIntroductionIntensive care unit (ICU) readmission is associated with increased mortality, hospital and ICU length of stay (LOS), and healthcare cost. Scoring systems that use physiologic markers to predict readmission have been used with varying degrees of success and literature is lacking on which medication classes might contribute to ICU readmission.ObjectivesThe primary objective of this study was to identify medication classes associated with preventable ICU readmissions.MethodsThis was a retrospective, single‐center, observational, and cross‐sectional study of adult patients readmitted to the ICU within 72 h of ICU discharge between June 2015 and December 2016. Patients were excluded if they had multiple ICU readmissions. Readmissions were classified as non‐medication related (NMIR), non‐preventable medication related (NPMIR), or potentially preventable medication related (PPMIR) relative to ICU readmission diagnosis. Clinical outcomes including hospital LOS, ICU LOS, ICU LOS for readmission period, overall mortality, or presence of a rounding ward clinical pharmacist were evaluated, as was the estimated cost of readmissions.ResultsA total of 173 patients were included. Seventy‐six readmissions were determined to be medication‐related (44%) with 43 (57%) of those deemed preventable. The medication classes identified in PPMIRs were diuretics (32.5%), anti‐infectives (14%), opioids (11.6%), benzodiazepines (11.6%), electrolytes (7%), and antiarrhythmics (7%). No difference was observed for median hospital LOS, ICU LOS, ICU LOS for readmission period or overall mortality between those patients with a NMIR, NPMIR and those with a PPMIR. Total avoidable ICU LOS was 240.8 days based on median LOS.ConclusionsDiuretics, benzodiazepines, opioids, antiarrhythmics, and anti‐infectives were the most frequently identified medication classes associated with PPMIRs. Further study is needed to identify the impact of screening for high‐risk medication classes identified in this investigation and greater pharmacist involvement post ICU discharge in reducing ICU readmissions.
Fast and reliable jackknife and bootstrap methods for cluster‐robust inference
Authors: MacKinnon James G. , Nielsen Morten Ørregaard , Webb Matthew D. 
Published: February 2023

SummaryWe provide computationally attractive methods to obtain jackknife‐based cluster‐robust variance matrix estimators (CRVEs) for linear regression models estimated by least squares. We also propose several new variants of the wild cluster bootstrap, which involve these CRVEs, jackknife‐based bootstrap data‐generating processes, or both. Extensive simulation experiments suggest that the new methods can provide much more reliable inferences than existing ones in cases where the latter are not trustworthy, such as when the number of clusters is small and/or cluster sizes vary substantially. Three empirical examples illustrate the new methods.
Optimizing the combined soft tissue repair and osteogenesis using double surfaces of crosslinked collagen scaffolds
Authors: Zhang Zhengchuan , He Qifen , Zhu Jinhao , Lin Xiaoxuan , Yang Yang , Chen Hongcheng , Huang Xiaoqiong , Xu Ruogu , Deng Feilong 
Published: February 2023

AbstractExcessive tissue damage or loss has been solved by guided tissue regeneration and guided bone regeneration theories. However, the unfavorable degradation property of the resorbable collagen scaffold brings a big challenge to support soft tissue stabilization and time‐consuming osteogenesis. The combined effect for soft tissue and bone of the collagen scaffold with better degradation pattern has not been clearly proven. This study determined whether the double surfaces of crosslinked collagen scaffolds could optimize the combined soft tissue repair and osteogenesis. In this study, we applied the chemically crosslinking treatment to the commercially available collagen scaffolds. Surface characterization, mechanical property and cell proliferation in vitro were evaluated. Combined bilateral skin and bone defects were established with the smooth surface of scaffold facing the skin defect and the rough surface facing the bone defect on the calvaria of rat. Micro‐CT and histological evaluation were applied to determine the scaffold degradation pattern, soft tissue repair and osteogenesis. The crosslinked collagen scaffolds showed comparably favorable surface porosity, structure intactness, superhydrophilicity and mechanical properties. Compared to the native scaffolds, the crosslinked scaffolds could optimize the combined soft tissue repair and osteogenesis by preferably prolonged degradation time. Early pro‐angiogenesis facilitated soft tissue repair and osteogenesis by upregulated soft tissue matrix degradation and balanced pro‐osteogenesis with limited osteoclast‐mediated bone resorption. Taken together, this study offers a promising repair strategy for the combined soft tissue and bone defects. Further, the possible mechanism of controllable scaffold degradation should be conducted.
In vitro elution characteristics of antibiotic‐loaded polymethylmethacrylate cement and a calcium sulfate bone substitute using staphylococci isolated from orthopedic implant‐associated infections
Authors: Batista Campos Laura , Kurihara Mariana Neri Lucas , Santos Ingrid Nayara Marcelino , dos Reis Fernando Baldy , Salles Mauro José 
Published: February 2023

AbstractPolymethylmethacrylate (PMMA) remains the gold standard antibiotic carrier in the management of osteomyelitis. However, biodegradable ceramic carriers may exhibit more efficient antibiotic elution properties. Through zone of inhibition (ZOI) testing and biofilm killing assays, we assessed the in vitro elution efficacy of vancomycin released from calcium sulfate (PG‐CSH) and PMMA beads as carriers on clinical strains of Staphylococcus aureus and Staphylococcus epidermidis, which were isolated from sonication fluid of orthopedic implant‐associated infections. Overall, vancomycin‐loaded PMMA and PG‐CSH beads showed potency (ZOI above 4 cm2) for up to 14 days against ATCC and clinical strains. Vancomycin‐loaded PG‐CSH beads displayed higher rates, exhibited a more stable antibiotic elution, had greater impacts on bacterial colony‐forming unit counts and produced higher ZOIs; additionally, statistically significant differences (Student's t test) were observed in different time sets during the experiment. In the biofilm killing assay, PG‐CSH loaded with vancomycin resulted in more bacterial deaths. In conclusion, in the present study, both PG‐CSH and PMMA beads acted as good carriers, but greater antimicrobial elution and biofilm bacterial killing were observed with PG‐CSH than PMMA. Future in vitro research should focus on testing other difficult‐to‐treat clinical strains, including multidrug resistant coagulase‐negative staphylococci and Gram‐negative bacilli.