bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDY OF CIVIL SAFETY ISSUES IN THE TRAINING OF SPECIALISTS IN ENVERONMENTAL ENGINEERING AND CONSTRUCTION
Authors: Oksana Rohulska  , Anatoliy Nester  , Galyna Kalda  , Izabela Piegdoń  , Anastasja Prydoloba  
Published: May 2023

The article deals with the expediency of using multimedia technologies in the training of future specialists in environmental engineering and construction, including at the initial stage in the study of the subject "Introduction to the specialty". It is emphasized that these technologies open unprecedented prospects in solving important tasks and lead to the transition from the traditional scheme of transfer of reproductive knowledge to a new, creative form of learning. It is established that multimedia technologies in the classes of future specialists in environmental engineering and construction contribute to: the formation of professional skills through the use of Internet materials of different levels of complexity; improving listening skills with the help of authentic sound texts, film episodes; development of dialogue skills, improvement of professional correspondence skills, enrichment of professional vocabulary (both active and passive), which reflects a certain stage in the development of culture, various technical equipment, social and political structure of society; enrichment of students with cultural knowledge, including professional etiquette, features of traditions; improving knowledge through online exercises and tests.
It is proved that the use of multimedia presentations in the training of future specialists in environmental engineering and construction, provides the function of transmitting information, as well as receiving feedback in the process of its perception and assimilation, as information presented in visual form is most accessible to perception.
It is noted that the use of multimedia technologies in the training of future professionals contributes to the intensification and enrichment of the educational process, evokes a conscious perception of educational material, motivates and activates student learning, individualizes the process of studying specialties, diversifies classes, and promotes mental and creative skills. construction and civil security, increases interest in training and the level of professional skills.
Determination of Antimicrobial Susceptibility Pattern of Bacteria Isolated from Herbal Drugs Hawked in Onitsha Anambra State Nigeria
Authors: Frances Ejimofor, Chiamaka , Enoch Nwakoby, Nnamdi , Johnson Oledibe, Odira , Eziamaka Afam-Ezeaku, Chikaodili , Ann Mbaukwu, Onyinye 
Published: May 2023

This study aimed at the determination of antimicrobial susceptibility pattern of bacteria isolated from herbal drugs hawked in Onitsha Anambra State. The microbiological purity and antibacterial characteristics of six Nigerian herbal remedies with the stated efficiency of healing all manners of microbial infections were evaluated. The herbal remedies were discovered to be contaminated with the following microorganisms: Bacillus subtilis, Staphylococcus sp, Salmonella spp and E. coli. Qualitative phytochemical screening of the herbal remedies revealed the presence of saponin, tannins, alkaloids, anthraquinone and cardiac glycosides which suggest possible antimicrobial effect. The maximum activity of the herbal remedies in the test isolates was observed on Staphylococcus aureus, which showed clear zones of inhibition with diameters ranging from 7.00 to 13mm for the six herbal drugs respectively while it had low activity on E coli, with clear zones of inhibition of 6.00mm, to 14.00mm. The herbal extracts have shown appreciable antimicrobial activities comparable to the currently prescribed modern drugs tested. As a result, additional investigations on clinical efficacy trials, safety, toxicity, and affordability analyses must be initiated as soon as possible in order to proceed to the final step of synthesizing precursor molecules for novel effective antimicrobials.
Chronic Toxicological Assessment of Aqueous Extract of a Combination of Nauclea latifolia Root and Acalypha torta Leaf on the Liver, Kidney and Heart of Wistar Rat
Authors: Ezekwesili C. N. , Ezeigwe O. C. , Asomugha R. N. , Ekwunife C. A. , Ekwealor C. C. , Adindu S. C. , Orji E. C. 
Published: May 2023

Background: Nauclea latifolia and Acalypha torta are medicinal plants found in Nigeria with scientifically validated anti-diabetic properties. Although these herbal preparations are derived from natural sources, some of them may still possess the potential to cause some adverse reactions on the vital organs of the body.
Aim: This study was therefore designed to assess the chronic toxicological effects of orally administered aqueous extract of a combination of N. latifolia root and A. torta leaf on the liver, kidney, and heart of Wistar rats.
Materials and Methods: Hot aqueous extraction of the mixture of dried, pulverized samples was carried out for 24 hours at the laboratory temperature. After filtrations, the final filtrate was evaporated to dryness using Rotary Evaporator. Effects of the Nauclea latifolia Acalypha torta extract ( NLAT), on the liver, kidney, and heart were assessed following daily oral administration of the extract in alloxan-induced diabetic rats at the dose of 100.0 mg/kg for six months. Changes in body weight and blood glucose levels were monitored. All the indices of liver, kidney, and heart functions were estimated with the aid of Randox Diagnostic Test Kits following the manufacturer’s methods and a total of eighty-four rats (120-150g) were used.
Results: Results showed that the extract, NLAT, had a positive impact on body weight which correlates with the concomitant reduction in the average blood sugar levels. There was no observable significant differences (P>0.05) in the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) when compared with the controls. Total bilirubin (TB), direct bilirubin (DB), creatinine, and urea levels were within the normal ranges. Histopathological evaluations showed no perturbation of the normal architectures of the liver, kidney and heart.
Conclusion: The combination at the dose tested was well tolerated by the animals and there was no indication of hepatotoxicity, nephrotoxicity, or cardiotoxicity.
The Mediating Effect of Language Skills Development in the Relationship of Vocabulary Learning Strategies and Motivation to Learn
Authors: Andante Rochelle M. , Limpot Marilou Y. 
Published: May 2023

Aims: To determine if there is a relationship between motivation, vocabulary learning strategies, and language skills development among Senior high School students. To determine also the mediating effect of language skills development in motivation to learn and vocabulary learning strategies.
Study Design: Quantitative non-experimental design.
Place and Duration of the Study: The study was conducted among Senior High School students in Rizal Memorial College, Assumption College of Davao, and University of Mindanao during the school year 2022-2023.
Methodology: The respondents were 355 senior high school students from private schools in Davao City, Region 11, Philippines. The respondents were chosen using stratified random sampling. The data were collected using survey questionnaire.
Results: The overall results showed that the respondents had a moderate level of vocabulary learning strategies and high level of motivation and language skills development. It also showed a significant relationship between three variables: motivation to learn, vocabulary learning strategies, and language skills development. Results also showed that language skills development had a partial mediation in the relationship of motivation to learn and vocabulary learning strategies.
Conclusions: The high level of motivation to learn and language skills development indicates that motivation is already shown in students and developing their language skills is often manifested in them. However, the moderate level of vocabulary learning strategies indicates that students are not always using the strategies to improve their vocabulary. Thus, researcher recommends that teachers provide activities like mystery word, dictionary dig, digital vocabulary field trip and many more for students to use vocabulary learning strategies and enhance their interest in learning. More importantly, teachers should emphasize to students the importance of believing in themselves as stated in self-efficacy theory.
Implementation of Place Based Education in Lower Primary English Class in Southern Part of Trashigang Dzongkhag, Bhutan
Authors: Kelzang  , Wangmo Kesang , Daker Sonam , Lhadon Pema 
Published: May 2023

Aims: To explore how Place-Based Education (PBE) is implemented in teaching English in lower primary class. It also explored on the challenges and opportunities the PBE offers as a teaching-learning approach.
Study Design: The qualitative study with an case study design grounded on the social constructivist worldview was used in this study.
Methodology: Purposive sampling was used and collected data from twenty-two participants; five face-to-face interviews with teachers and four focus group discussions (FGD) with class II and III students, the data was also collected from one principal and analysed using thematic approach.
Results: The literature shows that PBE principles were used in several fields of education for different purposes. Further, research suggests that principles of PBE can help students to engage in a meaningful learning experience using local community resources and boost students’ communication skills. In addition, the findings revealed that English teachers of lower primary classes implemented few principles of PBE such as learner-centered, inquiry-based, and community as classroom. On the other hand, teachers do not used local to global, design thinking and interdisciplinary approach due to time constraint and lack of experiences. Thus, the teachers do not fully utilize the local and community resources due to lack of competencies of teachers in terms of knowledge and skills to implement PBE approaches.
Conclusion: The study recommended that teachers be provided with a monthly refresher course on PBE principles to integrate into teaching English. In addition, administrator, parents and teacher colleagues render full support to implement PBE teaching. Therefore, future research is needed to ascertain how the principles of PBE are effective in helping learners improve academic achievement.
Comparative Study of Remnant Cholesterol, Some Lipid Fractions and FBS Level in Overweight and Obese Participants in South East Nigeria
Authors: Chinonso Nnamdi J. , Amah Ubuo K. , Anaelechi Onuegbu J. , Stellarmaris Okeke C. , Chukwudi Oti D. , Obioma Iwuagwu G. , Nwaisaac Ikechukwu S. , Chika Ahams E. 
Published: May 2023

Background: Obesity is one of the characteristics of metabolic disorders, it has been linked to cardiovascular diseases. Remnant cholesterol has been proposed to be a link between obesity and coronary heart disease, thus a risk factor for the development of cardiovascular disease in obese people. We compared the level of calculated non-fasting remnant cholesterol, fasting and non-fasting lipid profile and fasting blood sugar in overweight, obese and normal weight participants in Nnewi, a town in South East Nigeria.
Methods: In this cross-sectional study, a total of 90 apparently healthy obese, overweight and normal weight participants who met the inclusion criteria were randomly enrolled. They were grouped using their body mass index of 18.5 to 24.9 kg/m2 (normal weight), 25 to 29.9 kg/m2 (overweight) and ≥30 kg/m2 (obese). The parameters were analyzed using standard methods.
Results: Our results shows that there was progressive increase of remnant cholesterol among the group, this increase has no statistical difference (p>0.05) in the mean calculated remnant cholesterol (mmol/l) between the obese (0.72±0.4), overweight (0.68±0.46), and normal weight (0.50±0.28) participants. The mean fasting Very Low Density Lipoprotein (VLDL) and Triglyceride (TG) (mmol/l) were significantly higher (p<0.05) in overweight compared to normal weight participants (0.76±0.31 vs. 0.47±0.22) and (1.72±0.60 vs. 1.09±0.51) and obese participants (0.82±0.23 vs. 0.47±0.22) and (1.85±0.59 vs. 1.09±0.51) when compared to normal weight participants respectively. FBS levels (mmol/l) were significantly lower in normal weight participants when compared to overweight participants (3.45±0.79 vs. 4.46±1.82) and obese participants (3.46± 0.79 vs. 4.94±1.26).
Conclusion: The results obtained from this study demonstrated a progressive increase in the level of remnant cholesterol which was not statistically significant among apparently healthy individuals across the group. Furthermore we did not observed Remnant cholesterol as a sole predictor to obesity which will lead to cardiovascular diseases, with the rising prevalence of obesity in developing country as well as its associated complications and risks.
Network-based Toxicogenomics Approach to Unraveling the Influence of Lead and Cadmium Mixture on the Development and Progression of Hypertension
Authors: Olukunle Oluwatoyin Folake , Omoboyede Victor 
Published: May 2023

Heavy metals, generally characterized by high densities and atomic weights, are ubiquitous in the environment and are a public health concern due to the several health issues they pose to humans. Of all heavy metals, lead and cadmium among others are known to be capable of inducing multiple health effects even at a low rate of exposure. Hypertension (HYP), a major cause of death and a risk factor for other cardiovascular diseases, is known to be caused by both lead and cadmium. While the mechanism underlying the development of HYP induced by independent exposure to lead and cadmium has been well studied, the mechanism underlying the induction and progression of HYP upon lead and cadmium co-exposure remains mildly explored. Hence, this study aimed to elucidate the mechanism using a toxicogenomic approach. The set of genes affected by both heavy metals was identified using the comparative toxicogenomics database (CTD) while HYP targets were retrieved from the Gene Cards database. The shared genes between the heavy metals and the disease were identified and subjected to further analysis. The results of our analysis revealed the signaling pathways that are dysregulated by lead and cadmium co-exposure while oxidative stress, inflammation, and endothelial dysfunction were revealed as processes pertinent to the induction and progression of HYP by lead and cadmium co-exposure. Biomarkers that could be used for prognosis evaluation were also identified. Ultimately, this study supports and advances the growing body of finding on the roles played by lead and cadmium co-exposure in inducing HYP.
Perceived Impact of FishCORAL-Related Coastal Resource Management Interventions in Ragay, Camarines Sur, Philippines
Authors: Bergonio Emerson L. 
Published: May 2023

The paper presents the assessment study aimed to (a) determine the level of awareness of the fishers on the Coastal Resource Management initiatives of the FishCORAL project in Ragay, Camarines Sur, (b) document the knowledge, attitudes, and practices of the fishers on coastal resources management (hereafter referred as ‘CRM’), (c) identify the perceived socio-economic and ecological impacts of CRM initiatives, and (d) document the lessons to improve the implementation of fishery policies, programs, and plans for effective CRM initiatives. Using focus group discussion, key informant interview and observation methods, the present investigation depictede that respondents are extremely aware of the CRM interventions under the FishCORAL Project such as presence of markers in marine reserve and fish sanctuary, watch tower, Fishery Law Enforcement Team/bantay dagat operations, and patrol boat. Despite of significant increase in fish stock as observed by the respondents, no positive impact yet was felt by the fisherfolks in terms of fish catch and income. Respondents, however, perceived the importance and future benefits of these interventions in ensuring sustainable fishery and other coastal resources of Ragay Gulf including the other ecosystem services it may offer to the coastal communities.
The study further revealed that illegal fishing and other prohibited economic activities within and nearby the fish sanctuary were curtailed due to the presence of installed buoy markers, established watch tower and seaborne surveillance/ patrol works. The availability of patrol boats and watch tower, which serves as Fishery Law Enforcement Team (FLET) headquarter, coupled with the regular manning or 24/7 monitoring by the FLETconsiderably contributed in minimizing and/or gradual reduction of illegal fishing activities within the municipal waters of Ragay.
Effect of Micronutrients on Growth and Yield of Banana (Musa spp.) Cv. Red Banana
Authors: Arthi L. R. , Shakila Arumugam 
Published: May 2023

The investigation on “Effect of micronutrients on growth and yield of banana (Musa spp.) cv. Red Banana (AAA)” was carried out to identify a suitable micronutrient concentration for enhancing the growth and yield of triploid banana cultivar Red Banana. The field experiment was laid out in Randomized Block Design in three replications with ten treatments. The treatments comprised of various micronutrient concentrations of NRCB Banana Sakthi applied at different intervals. The growth parameters viz., plant height, pseudostem girth, number of leaves plant-1, leaf area was found to be the highest in the treatment which received 2.0 per cent micronutrients at 45 days interval while the control recorded the least values for growth characters. Application of 2.0 per cent micronutrients at 45 days interval was most effective in enhancing the bunch and finger characters viz., number of hands bunch-1, number of fingers hand-1, total number of fingers bunch-1, length , girth and weight of the finger and weight of bunch,. It can be concluded that application of 2.0 per cent micronutrients at 45 days interval can be recommended as the best practice for enhancing the growth and yield of Red Banana (AAA).
Bacteriological Assessment of Critical Areas in Three Selected Units in Jodhpur Dental College General Hospital, Jodhpur Rajasthan, India
Authors: Murjanatu H. S. , Maryam I. R. , Ahmed A. Y. , Saeed S. A. , Anam P. R. , Rogo L. D. 
Published: May 2023

The hospital environment plays a crucial role in the chain of infection spread. Thus, there is need to attack the chain of infection at its weakest link as the most effective way in combating and/or preventing nosocomial infections. The study aims to assess the common aerobic pathogenic bacteria in the different departments of Jodhpur National University Dental Hospital and to establish the best disinfectant as well as disinfection procedure. A cross sectional descriptive study was conducted. Air and surface samples were taken before and after dental procedures from all the three departments within durations of 14 days. Different antiseptics were used so as to compare their effectiveness. Swabs taken from different places were streaked on blood agar plates and incubated at 37oC under aerobic conditions for 24 hours. After incubation, isolates obtained were appropriately identified. After aerobic incubation of the settle plates at 370C for 24hours, the colonies on each plate were counted and recorded as the number of bacteria carrying particles settling over the area of the plate in a given period of time. The level of bacterial contamination of air is usually expressed as the number of bacteria carrying particles per cubic millimeter. A total of 274 surface samples and 97 air samples were collected. Bacteria were isolated in all air samples while only 255 surface samples had growth. The predominant species in all services was Bacillus spp, followed by coagulase negative Staphylococci, Micrococcus luteus, aerobic spore formers and least was Pseudomonas aeruginosa. The bacteria isolated in the air were similar to those isolated from surfaces. In conclusion, lack of a universal procedure for surveillance of nosocomial infection, presence of pathogenic bacteria, poor hand hygiene and heavy contamination of some important surfaces are the most important problems in our hospitals.
Revisiting the Role of CD63 as Pro‐Tumorigenic or Anti‐Tumorigenic Tetraspanin in Cancers and its Theragnostic Implications
Authors: Dey Saurabh , Basu Soumya , Ranjan Amit 
Published: May 2023

AbstractCluster of differentiation antigen 63 (CD63) belongs to a superfamily of proteins, usually defined as tetraspanins which are known to transverse the bilayer membranes four times. The expression of CD63 has been shown to get altered in several cancers, where it has been demonstrated to act as both a tumor promoter and tumor suppressor. The present review describes the mechanism of how CD63 promotes tumor formation in certain cancer types while inhibiting in some other specific cancers. Glycosylation, a post‐translational process plays a significant role in regulating the expression and function of these membrane proteins. Being a crucial exosomal flag protein, CD63 has been found to get involved in endosomal cargo sorting as well as the production of extracellular vesicles. Increased expression of exosomal CD63 derived from advanced tumors has demonstrated its role in promoting metastasis. CD63 also regulates the characteristic and function of stem cells on which they get expressed. This particular tetraspanin has been discovered to participate in gene fusion to perform distinctive roles in certain specific cancer types like breast cancer and pigmented epithelioid melanocytoma. Furthermore, this review mentions twelve different microRNAs obtained from miRDB that might target CD63. A few theragnostic uses of this membrane protein are also discussed. Thereby, the review indicates that further studies on CD63 might prove it to be an effective therapeutic target in different cancers in the coming future.
The Role of Diet and Gut Microbiota Interactions in Metabolic Homeostasis
Authors: Guan Lizhi , Liu Ruixin 
Published: May 2023

AbstractDiet is a pivotal determinant in shaping the structure and function of resident microorganisms in the gut through different food components, nutritive proportion, and calories. The effects of diet on host metabolism and physiology can be mediated through the gut microbiota. Gut microbiota‐derived metabolites have been shown to regulate glucose and lipid metabolism, energy consumption, and the immune system. On the other hand, emerging evidence indicates that baseline gut microbiota could predict the efficacy of diet intervention, highlighting gut microbiota can be harnessed as a biomarker in personalized nutrition. In this review, the alterations of gut microbiota in different dietary components and dietary patterns, and the potential mechanisms in the diet‐microbiota crosstalk are summarized to understand the interactions of diet and gut microbiota on the impact of metabolic homeostasis.