bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanistic Insights into the Anti-Restenotic Effects of HSP27 and HO1 modulated by Reconstituted HDL on Neointimal Hyperplasia
Authors: Lee Bok-Soo , Kim Ye Ji , Lee Jo Woon Yi , Park Seongchan , Kim Nam Hyeong , Sa Deok Hyang , Kang Eun Sung , Han Seul Hee , Lee Ji Yeun , Ku Hyo Jung , Kim Sang-Wook , Kim Ki Yong , Park Jeong Euy , Kim Yong Ho 
Published: August 2023

Abstract
HDL therapy has demonstrated beneficial effects in acute stroke and acute myocardial infarction models by reducing infarct size. In this study, we investigated the inhibitory effects of reconstituted HDL (rHDL) on neointimal hyperplasia and elucidated its underlying mechanism using a balloon injury rat model. Histological analysis of the injured arteries showed a significant 37% reduction in the intima to media ratio in the group treated with 80 mg/kg rHDL compared to the injury-only group (p<0.05), indicating a specific inhibition of neointimal hyperplasia by rHDL. In vitro analysis confirmed that rHDL significantly suppressed smooth muscle cell (SMC) proliferation while promoting endothelial cell (EC) proliferation. Moreover, treatment with rHDL resulted in reduced infiltration of leukocytes and downregulation of MMP9 expression in the neointimal area. Notably, rHDL administration led to decreased expression of VCAM1 and HIF1α, accompanied by increased expression of heme oxygenase 1 (HO1). Overexpression of HO1 by rHDL effectively inhibited SMC proliferation both in vivo and in vitro. Furthermore, rHDL-mediated suppression of injury-induced HIF1α coincided with upregulation of HO1. Interestingly, HSP27 and HO1 exerted inhibitory effects on the expression of C-C chemokine receptors (CCR2, CCR5, and CCR7), while specifically inhibiting the expression of CX3C motif chemokine receptor 1 (CX3CR1) was observed only with HO1. These findings highlight the distinct roles of HSP27 and HO1 as potential regulatory factors in the progression of restenosis. Collectively, our study demonstrates that rHDL exerts a potent anti-neointimal hyperplasia effect by suppressing leukocytes infiltration and SMC proliferation while promoting EC proliferation.
A Data-Driven Global Flood Forecasting System for Medium to Large Rivers
Authors: Palash Wahid , Akanda Ali S. , Islam Shafiqul 
Published: August 2023

Abstract

Losses from catastrophic floods are driving intense efforts to increase preparedness and improve response to disastrous flood events by providing early warnings. Yet accurate flood forecasting remains a challenge due to uncertainty in modeling, calibrating, and validating a reliable early warning system. This paper presents the Requisitely Simple (ReqSim) flood forecasting system that includes key variables and processes of basin hydrology and atmospheric forcing in a data-driven modeling framework. The simplicity of the modeling structure and data requirements of the system allows for customization and implementation in any medium to large rain-fed river basin globally. The proposed system's efficacy is demonstrated in this paper through providing reliable forecasts for various river basins around the world. This include 3–10-day forecasts for the Ganges and Brahmaputra rivers in South Asia, 2–3-day forecast for the Amur and Yangtze rivers in East Asia, 5–10-day forecasts for the Niger, Congo and Zambezi rivers in West and Central Africa, 6–8-day forecasts for the Danube River in Europe, 2–5-day forecasts for the Parana River in South America, and 2–7-day forecasts for the Mississippi, Missouri, Ohio, and Arkansas rivers in the USA. The study also quantifies the effect of basin size, topography, hydrometeorology, and river flow controls on forecast accuracy and lead times. Results indicate that ReqSim's forecasts perform better in river systems with moderate slopes, semiarid to wet hydroclimatic conditions, and less flow controls. The simple structure, minimal data requirements, ease of operation, and reliable operational accuracy make ReqSim an attractive option for effective real-time flood forecasting in medium and large river basins worldwide.
Hypercoagulation/fibrinolysis suppression is a risk factor for severe intraventricular hemorrhage in preterm infants: a retrospective observational study
Authors: Kibe Masaya , Tokuhisa Takuya 
Published: August 2023

Abstract
The association between hypercoagulation/fibrinolysis supression and severity of intraventricular hemorrhage (IVH) in preterm infants has not been investigated. The study aimed to determine how the coagulation–fibrinolysis balance prior to IVH onset affects the severity of IVH. Participants included 72 preterm infants born at <33 weeks and 0 days of gestation. Blood-related data were analyzed prior to IVH onset. An ordered logistic regression model was created with gestational week, birth weight, non-reassuring fetal status, chorioamnionitis, fibrinogen, antithrombin activity, platelet count, soluble fibrin, thrombin–antithrombin complex, and plasmin–α2 plasmin inhibitor complex/plasminogen activator inhibitor 1 (PIC/PAI-1) ratio as the explanatory variables and severity of IVH as the objective variable. The Markov chain Monte Carlo method was used to estimate the model’s parameters. The expected value of the partial regression coefficient of the PIC/PAI-1 ratio was estimated to be -0.875, the 95% Bayesian confidence interval ranged from -1.555 to -0.261, and the posterior probability of the coefficient being negative was 99.78%, which can be interpreted as follows: the lower the PIC/PAI-1 ratio in the model, the more severe the IVH. Hypercoagulation/fibrinolysis suppression is a risk factor for severe IVH. Treatment targeting hypercoagulability and low fibrinolytic activity may prevent severe IVH.
Enhancing the performance of an open quantum battery by adjusting its velocity
Authors: Mojaveri Bashir , Bahrbeig Rasoul Jafarzadeh , Fasihi Mohammad Ali , Babanzadeh Sanaz 
Published: August 2023

Abstract
The performance of open quantum batteries (QBs) is severely limited by decoherence due to the interaction with the surrounding environment. So, protecting the charging processes against decoherence is of great importance for realizing QBs. In this work we address this issue by developing a charging process of a qubit-based open QB composed of a qubit-battery and a qubit-charger, where each qubit moves inside an independent cavity reservoir. Our results show that, in both the Markovian and non-Markovian dynamics, the charging characteristics, including the charging energy, efficiency and ergotropy, regularly increase with increasing the speed of charger and battery qubits. Interestingly, when the charger and battery move with higher velocities, the initial energy of the charger is completely transferred to the battery in the Markovian dynamics. In this situation, it is possible to extract the total stored energy as work for a long time. Our findings show that open moving-qubit systems are robust and reliable QBs, thus making them a promising candidate for experimental implementations.
Coral Health Thrives in Unprotected Reef Ecosystems in Southeast Nosy Be, Madagascar
Authors: Fuller Jace 
Published: August 2023

Abstract

The coral reefs in Madagascar hold a special importance in the Indian Ocean. The country is among the top 15 in the world for largest coral reef area, and it shelters the greatest diversity of corals and macroinvertebrates in the central and western Indian Ocean. Because of their importance to marine ecosystems, research and protection of these threatened areas is imperative. The objective of this study was to assess the nature of hard coral reef ecology in the southeast region of Nosy Be and to better understand the extent of coral bleaching and disease as it compares to past conditions. The method I used to assess live hard coral cover and coral composition was benthic survey methodology. Across 5 different sites around southeast Nosy Be, the presence of health conditions such as bleaching, diseases, algal assembly, and soft coral colonization was collected, and coral cover and taxonomic composition was collected and calculated. Results show that coral cover and biodiversity have increased in certain sites and that counts of health conditions at every site were low compared to each site’s coral cover and to past results found in 2015. These findings suggest that the overall health of corals around Nosy Be has improved and that the unprotected reefs around Lokobe National Park are likely comparable in coral cover than those protected sites. Accounts say that local communities have stopped disturbing their nearby reefs and have begun supporting and enacting regeneration projects at certain reefs on the island, ending anthropogenic disturbance as a health detriment and aiding the reefs in recovery and survival. More research, attention, and action should be placed on all fragile ecosystems in Madagascar, and the responsibility should be on the Malagasy government to look into establishing the presently studied sites as protected areas to ensure their continued success and survival.
Buying from the Fringe (too)
Authors: Bru Lluís , Cardona Daniel , Sákovics József 
Published: August 2023

Abstract
We analyze how to divide the requirements of a (public) firm into lots, when potential suppliers suffer from heterogeneous diseconomies of scale. The optimal design leads to all firms, included the disadvantaged competitors, the fringe, being active, despite the concomitant cost of increasing supplier profit. Setting large lots that only large firms can produce competitively is necessary; but also setting small lots that the fringe firms can competitively bid for, reduces procurement cost. If, in addition, some medium-sized lots are set aside for the fringe –as allowed by the US regulations, but not by the EU ones– procurement cost is further reduced.
JEL: H57, K23, L23, L51.
CMMSE Applications of the inverse degree index to molecular structures
Authors: Molina Edil D. , Rodriguez Jose M. , Sanchez Jose L. , Sigarreta Jose M. 
Published: August 2023

Abstract
The inverse degree index, also called inverse index, first attracted attention through numerous conjectures generated by the computer programme Graffiti.Since then its relationship with other graph invariants has been studied by several authors. In this paper we obtain new inequalities involving the inverse degree index, and we characterize graphs which are extremal with respect to them. In particular, we obtain several inequalities relating the inverse degree index with the first and second Zagreb indices, the general first and second Zagreb indices, the Forgotten index, the general sum-connectivity index, the Sombor index and the misbalance indeg index, and several parameters of the molecular graph as the number of vertices, the number of edges, the minimum degree and the maximum degree. Also, we compute the inverse degree index for some classes of chemical graphs. Furthermore, some applications are given to the study of the physicochemical properties of three classes of compounds: polyaromatic hydrocarbons, polychlorobiphenyls, and octane isomers.
MSC Classification: 05C09 , 92E10
Comparative analysis of the influence of temperature and precipitation on drought assessment in the Marmara region of Turkey: an examination of SPI and SPEI indices
Authors: Soydan Oksal Nazire Goksu 
Published: August 2023

Abstract

Drought is one of the most serious problems for human societies and ecosystems. Climate change has begun to affect the whole world, but regional climate change can have different effects. Precipitation is frequently used to determine drought; besides, temperature has started to be used in recent years. The effect of temperature on the occurrence of drought was investigated for the Marmara region, located in the northeast of Turkey. The spatiotemporal variability of drought in the Marmara region was analyzed by using the standardized precipitation index (SPI) and standardized precipitation evapotranspiration index (SPEI) for 3-, 6-, and 12-month series. Results show that SPEI droughts occur with longer duration and increased magnitude, which can be attributed to the rise in potential evapotranspiration rates with an increase in temperature. The correlation between SPI and SPEI is strong for the same time series, and the number of extreme drought values for SPI is higher than SPEI, while the number of severe and moderate drought values is lower compared to SPEI. The years 1989, 1990, 2001, 2007, and 2014 were characterized as the highest drought years throughout the region. The study concludes that temperature should be considered in future studies.
One-pot Synthesis of Chemical Delivery Systems for Gamma-aminobutyric Acid and its Analogues
Authors: Semyonkin Aleksey , Zavadovskiy Roman , Polivanova Anna , Abbasova Kenul , Shipulo Elena 
Published: August 2023

Introduction:
A one-pot synthesis route was proposed for the synthesis of chemical delivery systems of bifunctional compounds containing carboxylic- and amino groups, such as gamma-aminobutyric acid and its structural analogues, gabapentin and phenibut.

Methods:
To obtain targeted compounds, consecutive esterification, amidation, methylation, and reduction were employed in contrast to a more traditional approach that requires isolation and purification of semi-products after each reaction step.

Results:
A significant (nearly two-fold) increase in yields was observed when target compounds were synthesized using a one-pot approach compared to the conventional one.

Conclusion:
One-pot approach is a possible and beneficial way for the synthesis of chemical delivery systems for gabapentinoids and other drugs containing carboxylic and amino groups.
Influence of Spring Stiffness on the Loading Speed of the Falling Weight Deflectometer (FWD) in Bearing Capacity Evaluation of Cement Concrete Pavement
Authors: Nguyen Van Hieu , Thuy Van , Pham Cao Thang , Tran Nam Hung 
Published: August 2023

Introduction:
The bearing capacity evaluation of cement concrete runway pavement is one of the most important contents in the airfield operation. Among the methods for estimating bearing capacity, the Falling Weight Deflectometer (FWD) is the most widely used method because it does not damage the pavement structure and spends so much time. The equipment for evaluation should have suitable parameters, such as. magnitude and loading speed, to the actual operating loads.

Aims and Objectives:
Currently, the equipment to assess the bearing capacity of cement concrete pavements of highways and airports by falling weight has been widely used in the world and is being applied in Vietnam. The loading system consists of a falling block through a spring system acting on the pressure plate under the pavement with a certain falling height. In particular, the spring system plays an important role in controlling the speed of the load on the pavement. In Vietnam, the test standards (Industry Standard 22TCN335-06, Vietnamese Standard TCVN 11365-2016) for assessing the pavement bearing capacity by FWD equipment do not specify the selection of spring stiffness corresponding to different operating speeds of the vehicle. Therefore, it is difficult to use the equipment for pavements with operating speeds different from the standard.
In this paper, we study the effect of spring stiffness on the loading speed when considering different loading speeds corresponding to different speeds of vehicles moving in reality. This research is only limited to laboratory experiments. This study aims to determine the dependence of the loading magnitude and loading time on the damping spring stiffness of the dynamic loading equipment, that is, used as a basis for choosing the appropriate damping stiffness of FWD corresponding to actual vehicles.

Methods:
Among the methods for estimating the bearing capacity, the Falling Weight Deflectometer (FWD) is the most widely used method as it does not cause any damage to the pavement structure and spends much time. The equipment for evaluation should have suitable parameters, such as magnitude and loading speed, to the actual operating loads.

Results:
This paper presents the results of experimental research that determines the influence of the damping spring stiffness on the loading speed of the dynamic loading equipment on the model of the concrete slab in the laboratory.

Conclusion:
Based on the comparison of the FWD loading speed when using 02 damping springs with different stiffness, we propose the basis for choosing the damping system that conforms to the evaluation needs of different types of vehicles.
Evaluating Health-promoting Lifestyle Profile among Menopausal Women: A Meta-analysis
Authors: Moshfeghy Zeinab , Riazi Hedyeh , Hajian Sepideh , Montazeri Ali 
Published: August 2023

Background:
Menopause is one of the most drastic experiences in a woman's life because of a spectrum of vasomotor symptoms which affect the quality of life and lifestyle. Although many treatments for these symptoms are available, they can be used for only a short duration. The nonpharmacologic therapies associated with healthy lifestyle behaviors are increasing. Health-Promoting Lifestyle Profile- II (HPLP-II), a self-report questionnaire designed to assess an individual's engagement in health-promoting behaviors, has focused on six dimensions of behavioral health promotion. This study aimed to review the degree of lifestyle modification in menopausal women based on the questionnaire HPLP-II.

Methods:
A comprehensive search was conducted for articles using HPLP-II after literature as the identified instrument for menopausal women's lifestyle, followed by a meta-analysis.

Results:
Among 8525 unique titles, 13 studies with 2648 participants were included. Quality assessment was “good” for most of them. The summary effect of participant age was 55.78 years and 49.1 years for menopausal age. Analysis of the pooled studies yielded a mean HPLP total score of 127.69. There was no evidence of publication bias.

Conclusion:
Our meta-analysis showed a moderately rated health-promoting behavioral profile in menopausal women. The spiritual growth subscale received the highest score, whereas physical activity received the lowest score and was at the lower limit of the moderate range. Health policymakers, patients, and healthcare providers can use these results to improve the healthy lifestyles of menopausal women.
Impact of Coping Skills and Mental Health in Burnout among Healthcare Professionals during Pandemic COVID-19
Authors: Hyseni Blerte , Hajrullahu Vjosa , Kryeziu Blerta , Prekazi Lulejete , Taganoviq Besarta , Shabani Bujar , Gallopeni Florim 
Published: August 2023

Introduction:
Healthcare professionals face numerous challenges, such as increased risk of exposure to the SARS Cov-2 and infected patients, heavy workloads, and ethical dilemmas in their daily practice, compounded by a constantly evolving clinical environment. Moreover, the COVID-19 pandemic has exacerbated burnout rates among healthcare professionals due to prolonged working hours and other stressors such as environmental, physiological, and psychological.

Methods:
This study was designed as a cross-sectional and correlational investigation and included 691 healthcare providers, including physicians and nurses working in public healthcare institutions in Kosovo. The questionnaire comprised four sections: Socio-demographic, General Health Questionnaire-28 (GHQ-28), COPE Questionnaire, and Maslach Burnout Inventory (MBI).

Results:
The results indicated that healthcare professionals experienced emotional fatigue and depersonalization at average to high levels of 38.7%, respectively 87.0%, specifically, during the pandemic. While 88.0% of healthcare professionals reported experiencing personal success. Furthermore, 50.2% of healthcare professionals had Clinical Somatic Symptoms, 44.4% had Clinical Symptoms of Anxiety and Insomnia, 28.8% had Clinical Social Dysfunction, 34.5% had Clinical Symptoms of Depression, and 43.3% displayed Clinical Symptoms/Distress of GHQ-28 scores. The burnout scales, Emotional fatigue, and Depersonalization were positively and significantly correlated with all General Health Questionnaire scales.

Conclusion:
The study's findings highlight the critical importance of developing and implementing psychological interventions for healthcare professionals who are struggling with mental health issues and experiencing high levels of burnout. These interventions could be conducted individually or in groups and should be prioritized to support healthcare professionals' recovery. As the pandemic continues to impact healthcare professionals, it is crucial to enhance coping strategies within the workplace to maintain their well-being and potentially mitigate burnout rates for future pandemics. Thus, there is an urgent need to address the mental health challenges faced by healthcare professionals, and proactive measures should be taken to provide them with the necessary support and resources to cope effectively during these trying times.
Analisis Sifat Mekanik Pada Serat Bulu Ayam Dengan Campuran Pp Sebagai Material Komposit
Authors: Rifaldy Rikky , Nugraha Iwan , Suci Faradina Choria , Setiawan Reza 
Published: August 2023

Meningkatnya konsumsi ayam tidak disertai dengan pengolahan dan pemanfaatan limbahnya di mana limbah bulu ayam hanya dibuang secara percuma. Serat bulu ayam atau chiken feather fiber ini sangat berpotensi menjadi material komposit yang tentunya harus di treatmen khusus untuk menonjolkan sifat yang menguntungkan serta mereduksi sifat yang merugikan. Penelitian ini dimulai dari observasi permasalahan pada limbah bulu ayam di sekitar Kabupaten Karawang, Tujuan dari penelitian ini yaitu untuk melakukan pengamatan sifat thermal dan sifat mekanis dari material limbah bulu ayam yang dijadikan bahan komposit, untuk melakukan pengamatan dari pencampuran dua polimer dengan berbeda sifat dan karakteristiknya. Selanjutnya mengumpulkan studi literatur yang digunakan untuk mengumpulkan data yang dibutuhkan. Data yang diperoleh diolah sesuai dengan teori berdasarkan studi literatur yang didapatkan, dianalisa serta dilihat keterkaitan permasalahannya dengan tujuan penelitian, dan selanjutnya disimpulkan. Pada penelitian ini pengujian tarik dilakukan untuk mengetahui kekuatan komposit dengan penguatan natural fiber (serat bulu ayam) dengan matrik PP (polypropilen). Dengan melakukan pengujian tarik dapat diketahui tegangan maksimum, regangan dan modulus elastisitas pada spesimen yang diuji. Spesimen yang diuji ini memiliki bentuk dan ukuran sesuai dengan standar ASTM D 638-03 dengan variasi sampel dengan persentase spesimen A : 30% fiber : 70% PP , spesimen B : 50% fiber : 50% PP , spesimen C :70% fiber : 30% PP. Hasil pengujian menunjukkan spesimen A : 12.724 kg/f , Spesimen B : 4.1458 kg/f, spesimen C: 3.9214 kg/f.
Tacit knowledge sharing to improve teachers’ performance
Authors: Triana Triana , Rugaiyah Rugaiyah 
Published: August 2023

In the current industrial revolution 4.0 era, teachers are required to constantly develop themselves and improve their performance. This is because teachers are the frontliners who directly interact with students. Teachers are one of the spearheads in educational institutions that determine student success. Teachers who are of superior quality will certainly give their best performance. Therefore, this study aims to analyze how teachers are able to exploit the knowledge and skills that exist in themselves by optimizing all sources of knowledge around them through knowledge sharing activities among teachers, particularly tacit knowledge sharing so that they can improve their performance. The methodology used in this research is a systematic approach with the Systematic Literature Review method with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analysis) model from articles published from 2012 to 2022. Based on the results of these studies, it is learnt that knowledge sharing activities among teachers will encourage individual knowledge improvement and produce new knowledge as a process of exchanging knowledge both implied and explicit from each individual.