bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivities of the Asian Summer Monsoon Simulations to Physical Parameters for the Perturbed Parameter Ensemble of HadGEM3‐GC3.05
Authors: Zhang Xiaoqi , He Bian , Guo Zhun , Sexton David M. H. , Rostron John W. , Furtado Kalli 
Published: May 2023

AbstractThe simulation skill of the perturbed parameter ensemble (PPE) of HadGEM3‐GC3.05 on the mean climate pattern of the Asian summer monsoon (ASM) is evaluated in this study. The sensitivities of the model bias to the perturbed parameters are investigated based on metrics. The results show that the PPE mean (PPE‐20M) could effectively capture the general ASM precipitation and wind patterns, with a correlation coefficient of 0.78. PPE‐20M mainly shows positive precipitation biases over the tropical western Pacific, southern slope of the Tibetan Plateau, Indochina Peninsula, and South China and negative precipitation biases over the Indian continent and Bay of Bengal. The magnitude of the precipitation biases is more sensitive than its pattern to the variation of the perturbed parameters. Four parameters (ent_fac_dp, qlmin, ps_cloud‐ph, and psm) are found to be crucial for simulating the ASM precipitation intensity, and their combined effects are related to the simulated precipitation biases.
On the Energy‐Dependent Deep (L < 3.5) Penetration of Radiation Belt Electrons
Authors: Mei Yang , Li Xinlin , Zhao Hong , Sarris Theodore , Khoo Lengying , Hogan Benjamin , O’Brien Declan , Califf Sam 
Published: May 2023

AbstractDeep penetration of outer radiation belt electrons to low L (<3.5) has long been recognized as an energy‐dependent phenomenon but with limited understanding. The Van Allen Probes measurements have clearly shown energy‐dependent electron penetration during geomagnetically active times, with lower energy electrons penetrating to lower L. This study aims to improve our ability to model this phenomenon by quantitatively considering radial transport due to large‐scale azimuthal electric fields (E‐fields) as an energy‐dependent convection term added to a radial diffusion Fokker‐Planck equation. We use a modified Volland‐Stern model to represent the enhanced convection field at lower L to match the observations of storm time values of E‐field. We model 10–400 MeV/G electron phase space density with an energy‐dependent radial diffusion coefficient and this convection term and show that the model reproduces the observed deep penetrations well, suggesting that time‐variant azimuthal E‐fields contribute preferentially to the deep penetration of lower‐energy electrons.
Rapid Development of Systematic ENSO‐Related Seasonal Forecast Errors
Authors: Beverley J. D. , Newman M. , Hoell A. 
Published: May 2023

AbstractClimate models exhibit known systematic errors in their representation of the El Niño‐Southern Oscillation (ENSO). In this study, we show that such simulation errors are largely present in tropical seasonal prediction, even for short lead times. Regressing monthly forecast errors from 11 different operational models upon the observed ENSO state, we find that predicted ENSO‐related sea surface temperature anomalies (of either sign) for winter/spring are significantly extended or shifted to the west and are also too persistent during the ENSO decay phase, both common climate model errors. There are also corresponding precipitation forecast errors, most notably a robust westward shift of the ENSO‐related precipitation dipole that may impact predictions of extratropical teleconnections. These ENSO‐related errors develop within days after initialization regardless of month, including significant errors appearing in anomalous surface trade winds, and saturate so rapidly that they primarily depend upon the seasonal cycle rather than lead time.
A Global Assessment of the Controls on the Fractionation of Arc Magmas
Authors: Klein Benjamin Z. , Jagoutz Oliver , Schmidt Max W. , Kueter Nico 
Published: May 2023

AbstractDuring the differentiation of arc magmas, fractionating liquids follow a series of cotectics, where the co‐crystallization of multiple minerals control the melt compositional trajectories, commonly referred to as liquid lines of descent (LLD). These cotectics are sensitive to intensive properties, including fractionation pressure and melt H2O concentration, and changes in these variables produce systematic differences in the LLDs of arc lavas. Based on a compilation of experimental studies, we develop two major element proxies that exploit differences in LLDs to constrain the fractionation conditions of arc magmas. Near‐primary fractionating magmas evolve along the olivine‐clinopyroxene cotectic, which is pressure‐sensitive. We use this sensitivity to develop a proxy for early fractionation pressure based on the normative mineral compositions of melts with 8 ± 1 wt.% MgO. Fractionation in more evolved magmas is controlled by the clinopyroxene‐plagioclase cotectic, which is strongly sensitive to magmatic H2O contents. We use this relationship to develop an H2O proxy that is calibrated to the normative mineral components of melts with 2–4 wt.% MgO. These two proxies provide new tools for estimating the variations in pressure and temperature between magmatic systems. We applied these proxies to compiled major element data and phenocryst assemblages from modern volcanic arcs and show that in island arcs early fractionation is relatively shallow and magmas are dominantly H2O‐poor, while continental arcs are characterized by more hydrous and deeper early fractionation. These differences likely reflect variations in the relative contributions of decompression and flux melting in combination with distinct upper plate controls on arc melt generation.
Identifying the Deep‐Inflow Mixing Features in Orographically‐Locked Diurnal Convection
Authors: Chang Yu‐Hung , Chen Wei‐Ting , Wu Chien‐Ming , Kuo Yi‐Hung , Neelin J. David 
Published: May 2023

AbstractOrographically‐locked diurnal convection involves interactions between local circulation and the thermodynamic environment of convection. Here, the relationships of convective updraft structures over orographic precipitation hotspots and their upstream environment in the TaiwanVVM large‐eddy simulations are analyzed for the occurrence of the orographic locking features. Strong convective updraft columns within heavily precipitating, organized systems exhibit a mass flux profile gradually increasing with height through a deep lower‐tropospheric inflow layer. Enhanced convective development is associated with higher upstream moist static energy (MSE) transport through this deep‐inflow layer via local circulation, augmenting the rain rate by 36% in precipitation hotspots. The simulations provide practical guidance for targeted observations within the most common deep‐inflow path. Preliminary field measurements support the presence of high MSE transport within the deep‐inflow layer when organized convection occurs at the hotspot. Orographically‐locked convection facilitate both modeling and field campaign design to examine the general properties of active deep convection.
Global Impacts of El Niño on Terrestrial Moisture Recycling
Authors: Posada‐Marín José A. , Arias Paola A. , Jaramillo Fernando , Salazar Juan F. 
Published: May 2023

AbstractThe global impacts of El Niño on precipitation have been long‐recognized, but more understanding of the mechanisms behind this influence is needed. For instance, previous studies have largely overlooked the potential impacts of El Niño on terrestrial moisture recycling (TMR). We perform a 40‐year forward tracking simulation to derive a global climatology of recycled precipitation and use a composite analysis to investigate how El Niño affects TMR. We identify seven regions where the El Niño impact on TMR is most significant and find that, in these regions, changes in precipitation and TMR are directly related: they increase or decrease together. In addition, we find a marked latitudinal contrast between the Southern Hemisphere, where TMR increases during El Niño, and the Northern Hemisphere and the tropics, where it decreases. Our results indicate that the weakening and strengthening of TMR can be behind precipitation changes caused by El Niño globally.
Lunar Mantle Composition Based on Spectral and Geologic Analysis of Low‐Ca Pyroxene‐ and Olivine‐Rich Rocks Exposed on the Lunar Surface
Authors: Yamamoto Satoru , Nagaoka Hiroshi , Ohtake Makiko , Kayama Masahiro , Karouji Yuzuru , Ishihara Yoshiaki , Haruyama Junichi 
Published: May 2023

AbstractWe studied the lunar mantle composition based on the characteristics of low‐Ca pyroxene (LCP)‐rich and olivine‐rich rocks exposed on the lunar surface. Using data mining with SELENE (Kaguya) hyperspectral data, we found 531 sites with spectra dominated by an ultramafic LCP end‐member mineral, most of which are located in the Imbrium basin and the South Pole‐Aitken (SPA) basin. Stratigraphic analysis of each site revealed that LCP‐rich rock bodies are exposed on fresh geological features that are less affected by space‐weathering, such as steep slopes at peaks, and crater walls and ejecta deposits at smaller craters. We also found that, in the SPA and Imbrium basins, LCP‐rich bodies are more numerous and more widely distributed than olivine‐rich rocks, suggesting that LCP‐rich materials deep in the mantle were excavated during the formation of these huge basins. However, olivine‐rich rocks were abundant, and no LCP‐rich rocks were found in the Moscoviense, Crisium, and Humboldtianum basins, which are known to have almost‐zero crustal thicknesses, indicative of mantle excavation. Thus, our results suggest that the composition of rocks derived from the lunar mantle varies with the impact basin. Such a difference might indicate a layered structure of mantle composition, with the olivine‐rich upper mantle overlying the LCP‐rich mantle, a horizontal heterogeneity in the mantle composition, a regional heterogeneity in early lunar basaltic magmatism, or an impact melt origin. The layered structure or horizontal heterogeneity might have resulted from a mantle overturn caused by gravitational instability in the early stages of the lunar magma ocean.
Removing Numerical Pathologies in a Turbulence Parameterization Through Convergence Testing
Authors: Zhang Shixuan , Vogl Christopher J. , Larson Vincent E. , Bui Quan M. , Wan Hui , Rasch Philip J. , Woodward Carol S. 
Published: May 2023

AbstractDiscretized numerical models of the atmosphere are usually intended to faithfully represent an underlying set of continuous equations, but this necessary condition is violated sometimes by subtle pathologies that have crept into the discretized equations. Such pathologies can introduce undesirable artifacts, such as sawtooth noise, into the model solutions. The presence of these pathologies can be detected by numerical convergence testing. This study employs convergence testing to verify the discretization of the Cloud Layers Unified By Binormals (CLUBB) model of clouds and turbulence. That convergence testing identifies two aspects of CLUBB's equation set that contribute to undesirable noise in the solutions. First, numerical limiters (i.e., clipping) used by CLUBB introduce discontinuities or slope discontinuities in model fields. Second, nonlinear artificial diffusion employed for improving numerical stability can introduce unintended small‐scale features into the solution of the model equations. Smoothing the limiters and using linear artificial diffusion reduces the noise and restores the expected first‐order convergence in CLUBB's solutions. These model reformulations enhance our confidence in the trustworthiness of solutions from CLUBB by eliminating the unphysical oscillations in high‐resolution simulations. The improvements in the results at coarser, near‐operational grid spacing and timestep are also seen in cumulus cloud and dry turbulence tests. In addition, convergence testing is proven to be a valuable tool for detecting pathologies, including unintended discontinuities and grid dependence, in the model equation set.
A monolithically integrated microcantilever biosensor based on partially depleted SOI CMOS technology
Authors: Liu Yi , Tian Yuan , Lin Cong , Miao Jiahao , Yu Xiaomei 
Published: May 2023

AbstractThis paper presents a monolithically integrated aptasensor composed of a piezoresistive microcantilever array and an on-chip signal processing circuit. Twelve microcantilevers, each of them embedded with a piezoresistor, form three sensors in a Wheatstone bridge configuration. The on-chip signal processing circuit consists of a multiplexer, a chopper instrumentation amplifier, a low-pass filter, a sigma-delta analog-to-digital converter, and a serial peripheral interface. Both the microcantilever array and the on-chip signal processing circuit were fabricated on the single-crystalline silicon device layer of a silicon-on-insulator (SOI) wafer with partially depleted (PD) CMOS technology followed by three micromachining processes. The integrated microcantilever sensor makes full use of the high gauge factor of single-crystalline silicon to achieve low parasitic, latch-up, and leakage current in the PD-SOI CMOS. A measured deflection sensitivity of 0.98 × 10−6 nm−1 and an output voltage fluctuation of less than 1 μV were obtained for the integrated microcantilever. A maximum gain of 134.97 and an input offset current of only 0.623 nA were acquired for the on-chip signal processing circuit. By functionalizing the measurement microcantilevers with a biotin-avidin system method, human IgG, abrin, and staphylococcus enterotoxin B (SEB) were detected at a limit of detection (LOD) of 48 pg/mL. Moreover, multichannel detection of the three integrated microcantilever aptasensors was also verified by detecting SEB. All these experimental results indicate that the design and process of monolithically integrated microcantilevers can meet the requirements of high-sensitivity detection of biomolecules.
ExoDx prostate test as a predictor of outcomes of high-grade prostate cancer – an interim analysis
Authors: Tutrone Ronald , Lowentritt Ben , Neuman Brian , Donovan Michael J. , Hallmark Elliot , Cole T. Jeffrey , Yao Yiyuan , Biesecker Claire , Kumar Sonia , Verma Vinita , Sant Grannum R. , Alter Jason , Skog Johan 
Published: May 2023

Abstract
Background
Patient outcomes were assessed based on a pre-biopsy ExoDx Prostate (EPI) score at 2.5 years of the 5-year follow-up of ongoing prostate biopsy Decision Impact Trial of the ExoDx Prostate (IntelliScore).

Methods
Prospective, blinded, randomized, multisite clinical utility study was conducted from June 2017 to May 2018 (NCT03235687). Urine samples were collected from 1049 men (≥50 years old) with a PSA 2–10 ng/mL being considered for a prostate biopsy. Patients were randomized to EPI vs. standard of care (SOC). All had an EPI test, but only EPI arm received results during biopsy decision process. Clinical outcomes, time to biopsy and pathology were assessed among low (<15.6) or high (≥15.6) EPI scores.

Results
At 2.5 years, 833 patients had follow-up data. In the EPI arm, biopsy rates remained lower for low-risk EPI scores than high-risk EPI scores (44.6% vs 79.0%, p < 0.001), whereas biopsy rates were identical in SOC arm regardless of EPI score (59.6% vs 58.8%, p = 0.99). Also in the EPI arm, the average time from EPI testing to first biopsy was longer for low-risk EPI scores compared to high-risk EPI scores (216 vs. 69 days; p < 0.001). Similarly, the time to first biopsy was longer with EPI low-risk scores in EPI arm compared to EPI low-risk scores in SOC arm (216 vs 80 days; p < 0.001). At 2.5 years, patients with low-risk EPI scores from both arms had less HGPC than high-risk EPI score patients (7.9% vs 26.8%, p < 0.001) and the EPI arm found 21.8% more HGPC than the SOC arm.

Conclusions
This follow-up analysis captures subsequent biopsy outcomes and demonstrates that men receiving EPI low-risk scores (<15.6) significantly defer the time to first biopsy and remain at a very low pathologic risk by 2.5-years after the initial study. The EPI test risk stratification identified low-risk patients that were not found with the SOC.
Cognitive decline and risk of dementia in older adults after diagnosis of chronic obstructive pulmonary disease
Authors: Rosso Aldana , Månsson Tomas , Egervall Karl , Elmståhl Sölve , Overton Marieclaire 
Published: May 2023

AbstractCognitive screening has been proposed for older adults diagnosed with chronic obstructive pulmonary disease (COPD). Therefore, we examined the change over time in cognitive function and the risk of incident dementia in older adults after COPD diagnosis. A sample of 3,982 participants from the population-based cohort study Good Aging in Skåne was followed for 19 years, and 317 incident COPD cases were identified. The cognitive domains of episodic memory, executive function, and language were assessed using neuropsychological tests. Mixed models for repeated measures and a Cox model were implemented. Participants performed, on average, worse over time on all neuropsychological tests after COPD diagnosis in comparison to those without COPD, although statistical significance differences were only observed for episodic memory and language. The groups had a comparable risk of developing dementia. In conclusion, our results indicate that cognitive screening in the early stages of COPD may be of limited clinical relevance.
Assessment of efficacy and safety of advanced endoscopic irreversible electroporation catheter in the esophagus
Authors: Jeon Han Jo , Choi Hyuk Soon , Lee Jae Min , Kim Eun Sun , Keum Bora , Jeen Yoon Tae , Lee Hong Sik , Chun Hoon Jai , Jeong Seung , Kim Hong Bae , Kim Jong Hyuk 
Published: May 2023

AbstractNonthermal irreversible electroporation (NTIRE) is emerging as a promising tissue ablation technique. However, maintaining irreversible electroporation (IRE) electrodes against displacement during strong esophageal spasms remains an obstacle. The present study aimed to evaluate the efficacy and safety of newly designed balloon-type endoscopic IRE catheters. Six pigs were randomly allocated to each catheter group, and each pig was subjected to four ablations at alternating voltages of 1500 V and 2000 V. Esophagogastroscopy was performed during the IRE. The ability of balloon-type catheters to execute complete IRE with 40 pulses was assessed. The success rate was higher for the balloon-type catheter than that for the basket-type (12/12 [100%] vs. 2/12 [16.7%], p < 0.001). Following gross inspection and histologic analysis of the 1500-V vs. 2000-V balloon-type catheter revealed a larger mucosal damage area (105.3 mm2 vs. 140.8 mm2, p = 0.004) and greater damage depth (476 μm vs. 900 μm, p = 0.02). Histopathology of the ablated tissue revealed separated epithelium, inflamed lamina propria, congested muscularis mucosa, necrotized submucosa, and disorganized muscularis propria. Balloon-type catheters demonstrated efficacy, achieving full electrical pulse sequences under NTIRE conditions, and a safe histological profile below 2000 V (1274 V/cm). Optimal electrical conditions and electrode arrays pose ongoing challenges.
An injectable copolymer of fatty acids (ARA 3000 BETA) as a promising treatment for osteoarthritis
Authors: Toupet Karine , Jorgensen Christian , Noël Danièle 
Published: May 2023

AbstractOsteoarthritis (OA) is the most prevalent rheumatic disease and a fast growing cause of disability. Current pharmacological treatments include antalgics and non-steroid anti-inflammatory drugs to control pain and inflammation as well as slow acting drugs such as intra-articular (IA) administration of hyaluronic acid. Oral supplementation or diet rich in polyunsaturated free fatty acids are proposed but evidence for benefit is still under debate. We here investigated the therapeutic potential of ARA 3000 BETA, an injectable copolymer of fatty acids, at the structural level in OA. Collagenase-induced osteoarthritis model was induced in C57BL/6 mice by collagenase injection into knee joint. Mice were treated with one or two IA or four intra-muscular injections (IM) of ARA 3000 BETA. At sacrifice, knee joints were recovered for cartilage analysis by confocal laser scanning microscopy (CLSM) and bone analysis by micro-computed tomography system. OA histological scoring was performed after safranin O/fast green staining. Histological analysis revealed a protective effect against cartilage degradation in treated knee joints after IM and IA administration. This was confirmed by CLSM with a significant improvement of all articular cartilage parameters, including thickness, volume and surface degradation whatever the administration route. A slight protective effect was also noticed on subchondral bone parameters and knee joint calcification after IM administration and to a lesser extent, two IA injections. We demonstrated the therapeutic efficacy of injectable ARA 3000 BETA in OA with a protection against cartilage and bone alterations providing the proof-of-concept that clinical translation might be envisioned to delay disease progression.
Clinical spectrum and prognosis of pathologically confirmed atypical tumefactive demyelinating lesions
Authors: Zhang Yajing , Zhang Ting , Zhang Xuebin , Yan Xiaoling , Lei Jing , Liu Ran , Yang Yun , Zhang Chao , Zhang Jun , Zhang Ying , Yue Wei 
Published: May 2023

AbstractTo describe the clinical spectrum and prognosis of atypical tumefactive demyelinating lesions (TDLs), which were confirmed by pathology. A total of 11 patients were diagnosed with atypical TDLs confirmed by brain biopsy and surgery between January 2006 and December 2017. The clinical spectrum and prognosis in these patients were analyzed. The patients’ ages ranged from 29 to 62 years, with a mean age of 48.9 years; 72.7% were males. The Expanded Disability Status Scale (EDSS) of the patients with first onset was 2.36. Most of the patients started with limb numbness and weakness (45.5%) or alalia (27.2%). The mean time from symptom onset to biopsy or surgery was 12.9 days (3–30 days). Most of the patients had solitary lesions (72.7%), supratentorial lesions (90.9%, particularly predominant in the frontal, temporal, and parietal lobes), moderate edema (63.6%), mild mass effect (54.5%), and patchy lesions (54.5%). Among them, three patients were positive for myelin basic protein (MBP) and one patient was positive for myelin oligodendrocyte glycoprotein (MOG). The patients were followed up for an average of 6.9 years (2–14 years), and recurrent TDLs were observed in 2 patients. Except for the 2 patients who relapsed, only 1 of the 9 patients died; the other 8 patients improved or maintained the status quo (the EDSS scores were lower or unchanged). The patients did not have any serious nervous system injury at onset, and the main presentation included extremity weakness, headache or dizziness, and alalia. The most common form was patchy on MRI enhancement. Cerebrospinal fluid and demyelination test can be an indicator of TDLs, and seizures may be a poor prognostic indicator. Most atypical TDLs have monophasic courses and good outcomes. The effect of neurosurgery alone was good in our group, and the effect of surgery on atypical TDLs can be further studied.