bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel multi-stable sinusoidal chaotic map with spectacular behaviors
Authors: Ali Ahmed M Ali , Sriram Sridevi , Natiq Hayder , Ahmadi Atefeh , Rajagopal Karthikeyan , Jafari Sajad 
Published: August 2023

Abstract
Chaotic behavior can be observed in continuous and discrete-time systems. This behavior can appear in one-dimensional nonlinear maps; however, having at least three state variables in flows is necessary. Due to the lower mathematical complexity and computational cost of maps, lots of research has been conducted based on them. This paper aims to present a novel one-dimensional trigonometric chaotic map that is multi-stable and can act attractively. The proposed chaotic map is first analyzed using a single sinusoidal function; then, its abilities are expanded to a map with a combination of two sinusoidal functions. The stability conditions of both maps are investigated, and their different behaviors are validated through time series, state space, and cobweb diagrams. Eventually, the influence of parameter variations on the maps’ outputs is examined by one-dimensional and two-dimensional bifurcation diagrams and Lyapunov exponent spectra. Besides, the diversity of outputs with varying initial conditions reveals this map’s multi-stability. The newly designed chaotic map can be employed in encryption applications.
Controllable double optical bistability via photon and phonon interaction in a hybrid optomechanical system
Authors: Wang Zhen , Li Heng-Mei , Yang Bao-Hua , Jiang Cheng , He Yong 
Published: August 2023

Abstract
Optical bistability has been studied theoretically in a multi-mode optomechanical system with two mechanical oscillators independently coupled to two cavities in addition to direct tunnel coupling between cavities. It is shown that the bistable behavior of the mean intracavity photon number in the right cavity can be tuned by adjusting the strength of the pump laser beam driving the left cavity. In addition, the mean intracavity photon number is relatively larger in the red sideband regime than that in the blue sideband regime. Moreover, we show that the double optical bistability of the intracavity photon in the right cavity and the two steady-state positions of the mechanical resonators can be observed when the control field power is increased to a critical value. In addition, the critical values for the observation of bistability and double bistability can be tuned by adjusting the coupling coefficient between the two cavities and the coupling rates between cavity mode and mechanical mode.
Identification of core ion cyclotron instabilities on HL-2A tokamak
Authors: Liu Linzi , Tong Ruihai , Zou Xiaolan , Chen Haotian , Chen Yang , Dong Guanqi , Hao Guangzhou , He Xiaoxue , Han Yuxiao , Ji Xiaoquan , Liang Anshu , Li Bo , Li Jiquan , Li Yonggao , Liu Liang , Shi Zhongbin , Wei Huiling , Xia Fan , Xiao Guoliang , Yin Jiao , Yu Deliang , Yuan Boda , Zhu Yiren , Zhong Wulyu , Xu Min ,   HL-2A team
Published: August 2023

Abstract
Instabilities in multiplies of ion cyclotron frequency range are identified and termed as core ion cyclotron emission (ICE) in recent HL-2A neutral beam injection heated experiments. Characteristics of the core ICE are presented, including frequency dependence and harmonics features. The detected frequencies are found to agree well with the multiplies of the deuterium cyclotron frequency around the magnetic axis. Additionally, the core ICE exhibits a predominantly compressional property. Observations of distinct spectrum features and individual excitation of each harmonic have demonstrated that the core ICE harmonics are independent multiple modes. Notably, the variation of plasma current is a necessary condition for exciting the 4th harmonic ICE individually. The results suggest that the drive mechanism of core ICE varies between the different frequency ranges.
The Study of Geomagnetic Field Southeastern Part of an Najaf-Karbala Plateau, Central Iraq, by World Magnetic Model 2015
Authors: Ali Nibras F. , Al-Naji Ahmed Jawad , Al-Bermani Mohammed J. , Laftah Amer A. 
Published: August 2023

Abstract
In this paper numerical simulations of the Earth’s magnetic field in the south-eastern part of an Najaf-Karbala Plateau and to the north of the centre of An-Najaf governorate have been investigated using the WMM2015 model. The study area is located at (Latitude = 32.3180°-31.99°) N, (Longitude = 44.5160°-44.0690°) E, and ranging altitude between 20-90 m above sea level). The study area was divided into grid of (2000 points) by drawing parallel lines, the interspacing distance between two lines (1 Km). Each line would be divided into several nodes. The space between any two nodes about (0.25 Km), this is done by using Google earth program v.6, Collected the data were latitude, longitude, and elevation from sea level. The data applied by (WMM2015) model and the result data of earth magnetic field elements drawn by Surfer v.13 and converted to the contour map by using the gridding method to find the characteristics of Earth magnetic elements ( Total intensity (F), the East component(Y), Horizontal intensity (H), Down component(Z), the North component(X), Declination (D) ) and Inclination (I)). The contour maps of F, Y, and D have magnetic anomalies that observed the changing in the values in the north western part of the study area. This may be indicating the presence of magnetic anomalies as a result of the presence of subsurface rock structures caused by them, including base rocks or various faults.
Research prospects of graphene-based catalyst for seawater electrolysis
Authors: Li Xinyu , Liu Yingjie , Feng Yanhui , Tong Yunwei , Qin Zhenbo , Wu Zhong , Deng Yida , Hu Wenbin 
Published: August 2023

Abstract
Seawater has obvious resource reserve advantages compared to fresh water, and so the huge potential advantages for large-scale electrolysis of hydrogen production has been paid more attention to; but at the same time, electrolysis of seawater requires more stable and active catalysts to deal with seawater corrosion problems. Graphene-based materials are very suitable as composite supports for catalysts due to their high electrical conductivity, specific surface area, and porosity. Therefore, the review introduces the problems faced by seawater electrolysis for hydrogen production and the various catalysts performance. Among them, the advantages of catalysis of graphene-based catalysts and the methods of enhancement the catalytic performance of graphene are emphasized. Finally, the development direction of composite catalysts is prospected, hoping to provide guidance for the preparation of more efficient electrocatalysts for seawater electrolysis.
Analysis of temperature distribution in PV-integrated electrochemical flow cells
Authors: Santander Dorian , Whitley Shaun , Kim Jungmyung , Bae Dowon 
Published: August 2023

Abstract
Photovoltaic (PV)-integrated flow cells for electrochemical energy conversion and storage underwent a huge development. The advantages of this type of integrated flow cell system include the simultaneous storage of solar energy into chemicals that can be readily utilized for generating electricity. However, most studies overlook the practical challenges arising from the inherent heat exposure and consequent overheating of the reactor under the sun. This work aims to predict the temperature profiles across PV-integrated electrochemical flow cells under light exposure conditions by introducing a computational fluid dynamics–based method. Furthermore, we discuss the effects of the flow channel block architecture on the temperature profile to provide insights and guidelines for the effective remedy of overheating.
The incidence of translocation t(11;14) among patients with multiple myeloma in a single clinic
Authors: Jew Scott , Goldwater Marissa-Skye , Bujarski Sean , Regidor Bernard , Emamy-Sadr Marsiye , Swift Regina , Eades Benjamin , Said Jonathan , Berenson James R 
Published: August 2023

Abstract

Objectives
Data regarding bone marrow (BM) sampling and cytogenetic testing rates for identification of translocation (11q13;14q32) and their changes over time in a multiple myeloma (MM) population are limited. We analyzed these metrics at a clinic specializing in the treatment of MM.

Methods
A total of 760 BM aspirate samples from 351 patients were collected between August 2004 and October 2021. We analyzed BM sampling statistics, cytogenetic testing frequency, and the incidence rates for the t(11;14) translocation in a single clinic specializing in the treatment of MM.

Results
We report that most (54.4%) patients had only 1 aspirate collected; the main reason (64.6%) for BM collection was to confirm disease progression. Less than half (47.5%) of BM samples collected for evaluation of MM disease had cytogenetic testing, but the rates have markedly increased in recent years. Our data demonstrated an incidence rate of 19.3% for t(11;14).

Conclusions
This report suggests that some patients may need to retest for this genetic aberration due to the possibility of false negatives and the potential benefit of identifying the t(11;14) marker for patients who may be candidates for a highly effective targeted therapy consisting of the BCL-2 inhibitor venetoclax.
Evaluation of inpatient medication guidance from an artificial intelligence chatbot
Authors: Beavers Jennifer , Schell Ryan F , VanCleave Halden , Dillon Ryan C , Simmons Austin , Chen Huiding , Chen Qingxia , Anders Shilo , Weinger Matthew B , Nelson Scott D 
Published: August 2023

AbstractPurposeTo analyze the clinical completeness, correctness, usefulness, and safety of chatbot and medication database responses to everyday inpatient medication-use questions.MethodsWe evaluated the responses from an artificial intelligence chatbot, a medication database, and clinical pharmacists to 200 real-world medication-use questions. Answer quality was rated by a blinded group of pharmacists, providers, and nurses. Chatbot and medication database responses were deemed “acceptable” if the mean reviewer rating was within 3 points of the mean rating for pharmacists’ answers. We used descriptive statistics for reviewer ratings and Kendall’s coefficient to evaluate interrater agreement.ResultsThe medication database generated responses to 194 (97%) questions, with 88% considered acceptable for clinical correctness, 76% considered acceptable for completeness, 83% considered acceptable for safety, and 81% considered acceptable for usefulness compared to pharmacists’ answers. The chatbot responded to only 160 (80%) questions, with 85% considered acceptable for clinical correctness, 65% considered acceptable for completeness, 71% considered acceptable for safety, and 68% considered acceptable for usefulness.ConclusionTraditional search methods using a drug database provide more clinically correct, complete, safe, and useful answers than a chatbot. When the chatbot generated a response, the clinical correctness was similar to that of a drug database; however, it was not rated as favorably for clinical completeness, safety, or usefulness. Our results highlight the need for ongoing training and continued improvements to artificial intelligence chatbots for them to be incorporated reliably into the clinical workflow. With continued improvement in chatbot functionality, chatbots could be a useful pharmacist adjunct, providing healthcare providers with quick and reliable answers to medication-use questions.
The Longitudinal Relationship Between Concussion History, Years of American Football Participation, and Alcohol Use Among Former National Football League Players: an NFL-LONG Study
Authors: Lang Brittany , Kerr Zachary Yukio , Chandran Avinash , Walton Samuel R , Mannix Rebekah , Lempke Landon B , DeFreese J D , Echemendia Ruben J , Guskiewicz Kevin M , Meehan III William P , McCrea Michael A , Brett Benjamin L 
Published: August 2023

Abstract

Objective
Investigate the relationships between concussion history and years of football participation (repetitive head impact proxy) with alcohol use across multiple decades in former professional football players.

Methods
Participants (n = 348; mean age = 49.0 ± 9.4) completed health questionnaires in 2001 and 2019, which included self-reported concussion history and years of participation. Alcohol use frequency and amount per occasion were reported for three timepoints: during professional career, 2001, and 2019. Ordinal logistic regression models were fit to test associations of concussion history and years of participation with alcohol use at each timepoint.

Results
There were no significant associations between either concussion history or years of football participation with alcohol use (frequency and amount per occasion) at any timepoint. Effect estimates for concussion history and years of football participation with alcohol use were generally comparable across timepoints.

Conclusions
Later life alcohol use by former American football players is not associated with concussion history or years of exposure to football.
Clinical Results of Mentor MemoryGel Xtra Breast Implants From the GLOW Clinical Trial
Authors: Alderman Amy , Caplin David , Hammond Dennis C , Keane Alexandra , Turetzky Jay , Kane William J 
Published: August 2023

Abstract

Background
Mentor MemoryGel Xtra breast implants (Mentor Worldwide LLC, Irvine, CA) were designed to maintain the soft, natural feel of MemoryGel implants while increasing fullness and projection and minimizing wrinkling, rippling, and related complications through optimization of shell gel-fill.

Objectives
To measure 3-year safety and effectiveness of MemoryGel Xtra breast implants in the Mentor MemoryGel and MemoryShape Combined Cohort Clinical Study.

Methods
Participants were implanted with MemoryGel Xtra breast implants in a prospective, multicenter clinical trial. Rates of complications and reoperations were analyzed to assess device safety and BREAST-Q was employed to assess device effectiveness.

Results
Two hundred eighty-seven females receiving MemoryGel Xtra breast implants were enrolled. Complication rates in the primary augmentation cohort included rates of 1.5% for implant-related reoperation, 2.3% for explantation, and 1.5% for Baker grade III or IV capsular contracture. For the revisional augmentation cohort, these rates were 2.8% for implant-related reoperation, 4.3% for explantation, and 3.0% for capsular contracture. For the primary reconstruction cohort, these rates were 12.0% for implant-related reoperation, 12.3% for explantation, and 7.3% for capsular contracture. For the revisional reconstruction cohort, these rates were 7.1% for capsular contracture, with zero implant-related reoperations or explantations. There were no reports of infection or implant malposition or displacement in any of these cohorts. Each cohort showed significantly improved satisfaction with breasts and psychosocial and sexual well-being at 1 year following the primary procedure.

Conclusions
These data are consistent with legacy clinical data for MemoryGel and provide the first published safety and effectiveness data regarding the use of MemoryGel Xtra breast implants for breast augmentation and reconstruction.

Level of Evidence: 4
Robot-Assisted Latissimus Dorsi Flap Harvest for Partial Breast Reconstruction: Comparison With Endoscopic and Conventional Approaches
Authors: Eo Pil Seon , Kim Hyunbin , Lee Joon Seok , Lee Jeeyeon , Park Ho Yong , Yang Jung Dug 
Published: August 2023

Abstract

Background
Latissimus dorsi muscle flaps are widely utilized in breast reconstruction. Several methods have been introduced.

Objectives
The aim was to compare the outcomes of robot-assisted breast reconstruction with a latissimus dorsi muscle flap following partial mastectomy with the outcomes of conventional and endoscopic-assisted techniques.

Methods
In this prospective single-institution study, Korean females diagnosed with breast cancer who underwent partial mastectomy and breast reconstruction with a latissimus dorsi flap from March 2020 to December 2021 were included. The outcomes of surgery and patient satisfaction utilizing the conventional, endoscopic-assisted, and robot-assisted techniques were compared.

Results
In total, 57 patients were included in this study, among whom 20 underwent conventional reconstruction, and 17 and 20 patients underwent endoscopic and robotic surgery, respectively. There was no statistically significant difference between the 3 methods in postoperative opioid analgesic dosage (P = .459), hospitalization period (P = .225), or the average total amount of donor site drainage during hospitalization (P = .175). With regard to patient satisfaction after surgery, especially regarding the donor site scar, the conventional method showed a significantly lower score than the other 2 techniques.

Conclusions
Robot-assisted breast reconstruction with a latissimus dorsi muscle flap after partial mastectomy showed higher patient satisfaction than that for the conventional open method. Because robotic surgery is more convenient than the endoscopic technique, it is potentially a good alternative to conventional open or endoscopic surgery.

Level of Evidence: 4
DANGER analysis: risk-averse on/off-target assessment for CRISPR editing without a reference genome
Authors: Nakamae Kazuki , Bono Hidemasa 
Published: August 2023

Abstract

Motivation
The CRISPR-Cas9 system has successfully achieved site-specific gene editing in organisms ranging from humans to bacteria. The technology efficiently generates mutants, allowing for phenotypic analysis of the on-target gene. However, some conventional studies did not investigate whether deleterious off-target effects partially affect the phenotype.

Results
Herein, we present a novel phenotypic assessment of CRISPR-mediated gene editing: Deleterious and ANticipatable Guides Evaluated by RNA-sequencing (DANGER) analysis. Using RNA-seq data, this bioinformatics pipeline can elucidate genomic on/off-target sites on mRNA-transcribed regions related to expression changes and then quantify phenotypic risk at the gene ontology term level. We demonstrated the risk-averse on/off-target assessment in RNA-seq data from gene-edited samples of human cells and zebrafish brains. Our DANGER analysis successfully detected off-target sites, and it quantitatively evaluated the potential contribution of deleterious off-targets to the transcriptome phenotypes of the edited mutants. Notably, DANGER analysis harnessed de novo transcriptome assembly to perform risk-averse on/off-target assessments without a reference genome. Thus, our resources would help assess genome editing in non-model organisms, individual human genomes, and atypical genomes from diseases and viruses. In conclusion, DANGER analysis facilitates the safer design of genome editing in all organisms with a transcriptome.

Availability and implementation
The Script for the DANGER analysis pipeline is available at https://github.com/KazukiNakamae/DANGER_analysis. In addition, the software provides a tutorial on reproducing the results presented in this article on the Readme page. The Docker image of DANGER_analysis is also available at https://hub.docker.com/repository/docker/kazukinakamae/dangeranalysis/general.
Phylogeny and infrageneric classification of Clerodendrum (Lamiaceae)
Authors: Satthaphorn Jiratthi , Paton Alan J , Zuntini Alexandre R , Cowan Robyn S , Leeratiwong Charan 
Published: August 2023

Abstract
The infrageneric classification of the genus Clerodendrum (Lamiaceae) has been highly problematic due to different concepts and subdivisions being applied to the treatment of Asian, Australian, and African species. Earlier molecular phylogenetic studies based on Sanger sequencing and limited sampling have indicated that previous morphology-based infrageneric classifications are not congruent with the phylogeny due to morphological convergence in many lineages. Advances in high-throughput DNA sequencing provide more information allowing more robust phylogenetic reconstruction at larger scale. We present the first comprehensive phylogenetic study of Clerodendrum that includes representatives of all previously recognized infrageneric taxa and using targeted sequencing data obtained from the Angiosperms353 enrichment to resolve the phylogenetic relationships. In agreement with previous phylogenetic work, our phylogeny shows that Asian and Australian species form a sister clade to an African Clade. Clerodendrum is monophyletic with the exclusion of some tropical coastal species, including some Australian species, which fall within a clade containing Volkameria and New World genera. We recognize two subgenera: subgen. Clerodendrum for Asian and Australian species and the new subgen. Afroclerodendrum for African and Malagasy species. Our findings support an infrageneric classification of Clerodendrum with a total of 13 sections based on molecular phylogenetic evidence and morphology that clearly accommodate the Asian, remaining Australian, and African species. Of these, we propose three new sections: sect. Albiflora, sect. Fortunata and sect. Megaflora for clades presenting unique morphological characters. The sectional classification and taxonomic consequences are discussed.
Characteristics and Outcomes of US Veterans With Immunocompromised Conditions at High Risk of SARS-CoV-2 Infection With or Without Receipt of Oral Antiviral Agents
Authors: Gentry Chris A , Nguyen Phoi N , Thind Sharanjeet K , Kurdgelashvili George , Williams Riley J 
Published: August 2023

Abstract

Objectives
Molnupiravir and nirmatrelvir-ritonavir were the first oral antiviral agents to demonstrate reduced hospitalization or death in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but patients with immunocompromised conditions were not well-represented. The objective of this study was to characterize and compare the clinical outcomes of US veterans with immunocompromised conditions prescribed oral antivirals with those who did not receive oral antivirals for mild-to-moderate SARS-CoV-2 active infection.

Methods
This was a retrospective, observational, nationwide propensity-matched analysis of US veterans with immunocompromised conditions who developed documented SARS-CoV-2 infection. The primary outcome was the composite of any hospitalization or death within 30 days of diagnosis. Secondary outcomes included 30-day comparative rates of (1) any hospitalization, (2) death, (3) intensive care requirement, and (4) subset analyses of outcomes by oral antiviral used and vaccination status.

Results
The composite primary outcome was significantly lower in patients receiving oral antiviral therapy compared with those who did not (23/390 [5.9%] vs 57/390 [14.6%]; odds ratio, 0.37; 95% confidence interval, .22–.61). This difference was driven largely by fewer deaths in the oral antiviral group (1/390 [0.3%] vs 19/390 [4.9%]; odds ratio, 0.05; 95% confidence interval, .007–.38). There was no significant difference in rate of intensive care requirement. The composite outcome was improved in vaccinated patients (completing the first series or first booster dose) who received oral antiviral agents compared with those who did not receive oral antiviral agents. Compared with those prescribed nirmatrelvir-ritonavir, patients given molnupiravir were older, had a higher incidence of cautions/contraindications, greater prevalence of tobacco use, and more cardiovascular complications.

Conclusions
Use of molnupiravir or nirmatrelvir-ritonavir was associated with lower incidences of hospitalization or death within 30 days of diagnosis in US veterans with immunocompromised conditions, regardless of vaccination status. These findings support the use of either oral antiviral in this patient population.