bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metaphorical Construction of Chinese Female Images in Media
Authors: Hong X. 
Published: January 2025

Introduction. Media is closely related to discourse. Female metaphor in the media is not a simple reflection of the objective world, but a selective and conscious construction of female image in social reality. This study explores the metaphorical construction of Chinese female images in the blessings for women on “Women’s Day” through the media.Methodology and sources. While some words similar to the meanings of “Women’s Day” were selected as keywords, the researcher searched the Wechat platform for articles with the title including these keywords. Then, a total of 306 female metaphors were manually identified and selected as a corpus. With word frequency statistics of the corpus, this study sorted out the categories of Chinese female metaphors and analyzed female image constructed in the media.Results and discussion. It was found that the source domains of female metaphors mainly include plant, animal, daily object, fictional character, nature and environment. The female metaphors can be analyzed from the following categories: Woman is a Flower; Woman is Water; Woman is Half the Heaven; Woman is Light; Woman is a Fairy; Woman is a Book; Woman is a Tiger; Woman is a Jewel. Among them, “Woman is a Flower” is the most frequent one and dominates the female metaphors, while the beauty of “flowers” reflects the beauty of women, the blooming of “flowers” reflects the youth of women, and the aroma of “flowers” reflects the charming of women. “Woman is Water”, “Woman is Half of the Heaven”, “Woman is Light” are also frequent female metaphors, constructing the tenderness, high social status, unique charm and outstanding contribution of female. Other female metaphors also play a certain role in the construction of holiness, wisdom, independence, confidence, strength, precious character of female image. These metaphors construct diversified images in terms of the appearance, character, ability and value of women, and most of the women constructed are beautiful and gentle.Conclusion. It can be seen that the construction of female image in the media becomes diversified on the one hand, on the other hand it still follows the traditional thinking pattern. The paper suggests that gender discourse in the media has been diversified and improved, but still needs to strengthen the construction of equal female image in the harmonious society.
Insuficiencia de normativa específica y la limitación a la efectividad del sistema judicial ecuatoriano en el tratamiento de la alienación parental en los procesos de tenencia
Authors: Guanín Guevara Luis Fernando , Batista Hernández Noel 
Published: January 2025

Introducción: El presente artículo permite determinar cómo la insuficiencia de la normativa específica limita la efectividad del sistema judicial ecuatoriano en el tratamiento de la alienación parental en los procesos de tenencia. Objetivo: Determinar cómo la insuficiencia de la normativa específica limita la efectividad del sistema judicial ecuatoriano en el tratamiento de la alienación parental en los procesos de tenencia. Metodología: Se utiliza como metodología el enfoque mixto (cuantitativo- cualitativo). Y métodos descriptivo-explicativo-propositivo y no experimental transversal. Resultados: Se identificó que la legislación ecuatoriana no cuenta con una normativa específica que aborde la alienación parental, pero se reconoce la importancia de proteger los derechos de los niños en los procesos de tenencia. Se determina la importancia de implementar un marco legal que incluya una definición clara del fenómeno para identificar y evaluar la alienación parental, así como protocolos para los procesos de tenencia. Se propone modificar y reformar el Código de la Niñez y Adolescencia, e implementar una Ley Orgánica de Prevención y Combate a la Alienación Parental. La propuesta incluye definir la alienación parental, establecer mecanismos de prevención y detección, así como obligar a los jueces y operadores de justicia a considerarla en los procesos de tenencia, custodia y visitas. Conclusión: La ausencia de una legislación clara sobre el tema deja a los jueces sin herramientas legales para identificar, evaluar y manejar la alienación parental de manera eficaz. Esto vulnera derechos. Área de estudio general: Derecho Área de estudio específica: Derecho civil.
B-learning en el proceso enseñanza aprendizaje en competencia del bachillerato técnico en contabilidad
Authors: Carrillo López Franklin Hernán , Macas Allauca Segundo Raúl , Ramírez Gutiérrez César Vicente , Martínez Pérez Odette 
Published: January 2025

Introducción: la evolución de la tecnología en el aula ha revolucionado la enseñanza y ha permitido un acceso más amplio a los recursos educativos, una mayor flexibilidad en la enseñanza y una mejor implementación, mejorando al mismo tiempo la compresión y la retención de la información por parte de los alumnos. Objetivo: analizar cómo la implementación de B-Learning, a través de un aula virtual diseñado específicamente para la enseñanza de contabilidad general, afecta el proceso de enseñanza-aprendizaje en el bachillerato técnico. Además, se evalúa su impacto en la calidad educativa y en la preparación profesional de los estudiantes. Metodología: la investigación utilizó un diseño no experimental de corte transversal, combinando enfoques cuantitativos y cualitativos. El estudio tuvo un carácter exploratorio y se utilizó el método inductivo para interpretar los datos. La muestra estuvo compuesta por 160 estudiantes y 6 docentes de contabilidad de la Unidad Educativa Isabel de Godín. Para recopilar datos, se utilizaron cuestionarios y entrevistas. Resultados: los resultados indican que un 72% de los estudiantes percibió mejoras en su comprensión de los temas gracias a estas metodologías, y un 69% considera que las aulas virtuales facilitan el aprendizaje. Además, un 68% de los estudiantes prefieren usar este tipo de aulas para enriquecer las clases. Sin embargo, persisten problemas relacionados con el acceso a la tecnología y la preferencia por métodos de enseñanza tradicionales, lo que se refleja en las respuestas negativas que oscilan entre el 9% y el 17%. Conclusión: a través de este estudio se ha podido determinar que la ejecución del B-Learning, en concreto, la utilización de aulas virtuales en la docencia de contabilidad en la secundaria técnica de contabilidad general logra una superioridad significativa en la comprensión de conceptos contables complicados. Los resultados confirman la ventaja de las herramientas digitales y los ejercicios interactivos. Área de estudio general: Educación. Área de estudio específica: Contabilidad General. Tipo de estudio: Artículos originales.
The economic burden of post-endoscopic retrograde cholangiopancreatography (ERCP) procedure infections in Italy
Authors: Sciattella Paolo , Fornero Annarosa , Giordano Susanna , De Angelis Claudio , Cattel Francesco 
Published: January 2025

Introduction: The infections of multidrug-resistant organisms (MDROs) associated with duodenoscopes during endoscopic retrograde cholangiopancreatography (ERCP) procedure have become a significant cause for concern, especially in fragile patients. While the clinical impacts of these infections are well-documented, their economic implications remain underexplored. This study assesses the incidence and economic burden of post-ERCP infections in Italy using an administrative database.
Methods: We conducted a retrospective observational study using administrative databases from A.O.U. Città della Salute e della Scienza di Torino. The study included all patients who underwent their first inpatient ERCP between 2018 and 2021. Infections were identified using ICD-9-CM codes for Pseudomonas aeruginosa, Clostridium difficile, Escherichia coli, Klebsiella spp., and Staphylococcus aureus. A 1-year follow-up was defined in order to estimate healthcare resource utilization and related costs, including readmissions, drug prescriptions, and outpatient specialist and laboratory services.
Results: The study included 686 inpatient ERCP cases, an overall infection rate of 4.2% was observed. Higher infection rates were observed in women (4.6%), patients over 70 years old (4.6%), emergency admissions (5.1%), and transplant patients (19.1%). The average hospital stay doubled for infected patients (24.3 vs. 11.3 days; p=0.001). Post-ERCP infections led to a 28% increase in average costs (€12,256 vs. €9,561; p=0.048). With an annual volume of 25,000 ERCP procedures, post-ERCP infections in Italy contribute approximately €2.9 million in additional direct costs per year.
Conclusion: Post-ERCP infections impose substantial financial burdens on the healthcare system, underscoring the critical importance of implementing cost-effective prevention strategies to mitigate this public health threat in Italy.
Diabetic ketoacidosis treatment outcomes and its associated factors among adult patients with diabetes mellitus admitted to public hospitals in Nekemte Town, Ethiopia: a cross-sectional study
Authors: Mitiku Yigazu Daniel , Lema Matiyos , Bekele Firomsa , Tesfaye Daka Dawit , Samuel Dagim , Addisu Nigatu 
Published: January 2025

BackgroundDiabetic ketoacidosis (DKA) is a serious and acute complication of diabetes mellitus. In Ethiopia, the mortality associated with acute diabetes complications ranges from 9.8% to 12%. Despite this, there is limited information on the clinical outcomes of DKA in our study location. Therefore, this study aimed to assess the magnitude and associated factors of DKA treatment outcomes among adult patients with diabetes admitted to public hospitals in Nekemte Town, Ethiopia.ObjectiveTo assess the DKA treatment outcomes and their associated factors among adult patients with diabetes admitted to public hospitals in Nekemte Town.MethodsA 5-year cross-sectional study was conducted using a systematic random sampling technique among 201 patients from 1 July to 31 August 2023. DKA treatment outcomes were assessed at discharge. Pharmacists collected data by reviewing patient charts using Kobo Toolbox software. The data were then exported to SPSS Version 27 for analysis. Both bivariable and multivariable logistic regression analyses were performed. Variables with a P-value &lt; 0.25 in the bivariable logistic regression were entered into the multivariable regression analysis to control for potential confounders. An adjusted odds ratio with a 95% confidence interval was used to identify predictors of treatment outcomes. A P-value &lt; 0.05 was considered significant in the multivariable analysis.ResultComplete data was available for 201 patients admitted with DKA. The majority, 178 (88.6%), improved and were discharged. Independent predictors of DKA recovery were comorbidities [AOR: 3.45, 95% CI: 1.33, 9.72], admission Glasgow Coma Scale (GCS) score (&lt;8) [AOR: 2.74, 95% CI: 1.02, 7.34], random blood glucose (RBS) (≥ 500) [AOR: 3.07 (95% CI: 1.12, 8.39)], and urine ketones (≥ +3) [AOR: 3.24, 95% CI: 1.18, 8.88].Conclusion and recommendationMost of the treated patients with DKA were discharged with improvement. Comorbidity, admission GCS, RBS, and urine ketones were independently associated with DKA recovery. In general, significant consideration should be given to DKA prevention, early detection, and appropriate hospital management.
Stem cell status and prognostic applications of cuproptosis-associated lncRNAs in acute myeloid leukemia
Authors: Chai Zhuodong , Yuan Zhongyue , Chen Yifei 
Published: January 2025

IntroductionAcute myeloid leukemia (AML), a highly heterogeneous hematological malignancy, remains a major challenge in adult oncology. Stem cell research has highlighted the crucial role of long noncoding RNA (lncRNA) in regulating cellular differentiation and self-renewal processes, which are pivotal in AML pathogenesis and therapy resistance.MethodsThis study explores the relationship between cuproptosis-related lncRNAs and AML prognosis, providing novel insights into their impact on hematopoietic stem and progenitor cells.ResultsWe collected clinical information from 214 AML patients in our center and analyzed the association between granulocyte recovery after chemotherapy, cuproptosis, and prognosis. Additionally, we developed a prognostic model—the cuproptosis-associated long noncoding RNA prognostic model (CRLPM)—y analyzing data from The Cancer Genome Atlas (TCGA). Patients were stratified into high- and low-risk groups based on CRLPM, revealing significant survival differences. High-risk patients demonstrated lower sensitivity to chemotherapeutic agents such as Axitinib, GSK429286A, Navitoclax, and ZM-447439, underscoring the need for alternative therapeutic strategies.DiscussionCRLPM offers a promising framework for integrating stem cell-focused approaches into personalized treatment regimens, paving the way for precision medicine in AML management.
Community-engaged research enhances the scientific quality and societal impact of a long-term avian monitoring program in northwest Ecuador
Authors: Karubian Jordan , Olivo Jorge , Cabrera Domingo , Freile Juan , Browne Luke , Anderson H. Luke , Cabo Jairo , Paladines Gregory , Loor Gloria , Perlin Wilde Liat 
Published: January 2025

IntroductionThere has been a growing realization that a more inclusive approach to research can provide both ethical and practical benefits. Long-term avian monitoring programs, and indeed the academic and research community as a whole, are still learning how best to implement these methodologies effectively. MethodsThis paper provides information on a twenty-plus-year effort to conduct community-engaged avian monitoring in northwest Ecuador, with a focus on how this approach has impacted the quality and scope of the project’s science and broader societal impacts. We focus on three case studies that have been proceeding for varying lengths of time to highlight various stages of project development and maturity.ResultsA community-engaged approach has improved the quality of our scientific research by adding traditional ecological knowledge (TEK), technical capacity, and intellectual contributions to our monitoring efforts. Community-engaged research has also enhanced the breadth and quality of societal impacts, in terms of education, capacity building, and conservation, particularly in the formation of an ecological reserve that protects threatened species and habitat. We also discuss systemic and local challenges, and potential strategies to overcome these challengesDiscussionWe conclude that community-engaged research can improve the intellectual merit and broader societal impacts of long-term avian monitoring, and we advocate for continued investment, efforts, and careful reflection on best practices in this space.
Pre- and post-pandemic comparisons in cardiovascular markers: a population-based study
Authors: Nehme Mayssam , Zaballa Maria Eugenia , Rouzinov Serguei , Lamour Julien , Stringhini Silvia , Guessous Idris 
Published: January 2025

IntroductionThe COVID-19 pandemic, starting in 2020, raised concerns about potential long-term health impacts, including its effects on cardiovascular health and related biomarkers. This study part of the Bus Santé in Geneva, Switzerland, compared cardiovascular and metabolic profiles pre- (2016–2019) and post-pandemic (2023–2024) among individuals aged 30–75.MethodsParticipants completed questionnaires and underwent a clinical visit, including a physical examination and fasting blood test to assess lipid and glycemic profiles. Linear regression was used to estimate results including mean systolic and diastolic blood pressure, cholesterol, and glycemic profiles, after adjusting for age, sex, smoking, and socioeconomic status. Quantile regression models were used to estimate median values.ResultsA total of 4,558 participants were included. The study observed modest declines in mean glucose, cholesterol, HDL, and LDL levels post-pandemic, with stable blood pressure. The prevalence and treatment rates of diabetes, hypertension, and dyslipidemia remained consistent. Unawareness of these conditions was stable.ConclusionDespite initial fears of a pandemic-induced health debt, results indicate healthy cardiovascular profiles post-pandemic, likely driven by improved lifestyle behaviors. This study highlights the importance of monitoring of cardiovascular health and suggests that lifestyle improvements may offset potential adverse pandemic effects in developed nations like Switzerland.
Establishment and validation of a nomogram for coronary artery lesions in children with Kawasaki disease
Authors: Hu Chong , Yan Xiao , Song Henglian , Dong Qin , Yi Changying , Li Jianzhi , Lv Xin 
Published: January 2025

BackgroundThe nomogram is a powerful and robust tool in disease risk prediction that summarizes complex variables into a visual model that is interpretable with a quantified risk probability. In the current study, a nomogram was developed to predict the occurrence of coronary artery lesions (CALs) among patients with Kawasaki disease (KD). This is especially valuable in the early identification of the risk of CALs, which will lead to proper diagnosis and treatment to reduce their associated complications.MethodsRetrospective clinical data of 677 children diagnosed with KD who were treated in the Children's Hospital Affiliated with Shandong University were analyzed. All the participants were divided into the CAL group and no CAL group according to their coronary echocardiography results. Least absolute shrinkage and selection operator (LASSO) regression was applied for the identification of the most informative predictors of CAL. Based on this, a nomogram was developed for accurate risk estimation.ResultsThe data were divided into a training set and a validation set. Receiver operating characteristic analysis, calibration curves, and decision curve analysis all supported the high accuracy and clinical utility of this model. LASSO regression highlighted five key predictors: sodium, hemoglobin, platelet count, D-dimer, and cystatin C. A nomogram based on these predictors was established and successfully validated in both datasets. In the training set, the AUC was 0.819 and in the validation set it was 0.844. The C-index of the calibration curve in the training set was 0.820, while in the validation set it was 0.844. In the decision curve analysis, the predictive benefit of the model was greater than zero when the threshold probability was below 95% in the training set and below 92% in the validation set.ConclusionThe predictive factors identified through the LASSO regression approach and the development of the nomogram are important contributions in this respect. This model had a high predictive accuracy and reliability for identifying high-risk children in the very early stage of disease with remarkable precision, laying the foundation for personalized treatment strategies and targeted treatment and providing a strong scientific basis for precise therapeutic intervention.
Serum lipid profile in systemic lupus erythematosus
Authors: Xuan Jingxiu , Deng Chaoqiong , Lu Huiqin , He Yan , Zhang Jimin , Zeng Xiaoli , Sun Yuechi , Chen Shiju , Liu Yuan 
Published: January 2025

BackgroundDyslipidemia presents in various autoimmune diseases, and the serum lipid profile in systemic lupus erythematosus (SLE) has not yet been clearly defined. This study aims to evaluate the level of serum lipids in patients with SLE.MethodsA case–control study evaluated four conventional sera lipids—total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL)—in patients with SLE compared to healthy controls (HCs). Correlations between serum lipids and clinical characteristics were analyzed in patients with SLE. A systematic review and meta-analysis were conducted to assess the epidemiology of lipid profiles in patients with SLE, and a random-effects meta-analysis was performed for data synthesis.ResultsTC and TG were elevated significantly, and HDL decreased in patients with SLE compared to HCs. Elevated lipids were associated with progressive disease activity. TC, TG, and HDL were elevated in patients with SLE and were associated with decreased IgG, increased 24-h proteinuria, white blood cells (WBCs), and neutrophils. Decreased HDL and increased TG were associated with an increase in the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Patients with SLE who took glucocorticoids (GCs) may have experienced increases in TC and TG, while those who took hydroxychloroquine (HCQ) may have experienced increases in TC and HDL. Eleven eligible studies including the present study on associations between serum lipids and SLE were reviewed by the meta-analysis. The results demonstrated elevated TC (MD = 0.85, 95% CI 0.82 to 0.89, p &lt; 0.00001) and TG (MD = 0.96, 95% CI 0.94 to 0.99, p &lt; 0.00001) levels in SLE, while HDL decreased (MD = −0.19, 95% CI −0.20 to −0.17, p &lt; 0.00001).ConclusionsDyslipidemia is present in SLE. There was a significant association between SLE disease activity and TC, TG, and HDL. The exact pathogenesis of metabolic disorders in SLE needs to be further addressed.
Mixed radiation with different doses induces CCL17 to recruit CD8+T cell to exert anti-tumor effects in non-small cell lung cancer
Authors: Huang Liuying , Wang Duo , Xu Muchen , Qian Danqi , Cao Yulin , Wu Xiaohan , Ming Liang , Tang Junhui , Huang Zhaohui , Yin Yuan , Zhou Leyuan 
Published: January 2025

BackgroundDifferent doses of radiotherapy (RT) exert diverse effects on tumor immunity, although the precise irradiation method remains unknown. This study sought to elucidate the influence of combining different doses of RT with immune checkpoint inhibitors (ICIs) on the infiltration of CD8+T cells within tumors, thereby augmenting the anti-tumor response.MethodsConstructing a mouse model featuring bilateral lung cancer tumors subjected to high and low dose irradiation, the analysis of RNA transcriptome sequencing data and immunohistochemical validation for tumors exposed to various dosages guided the selection of the optimal low-dose irradiation scheme. Subsequently, upon the integration of immune checkpoint inhibitors (ICIs) therapy, the infiltration of immune cells within the tumor was ascertained via immunohistochemistry (IHC) and flow cytometry (FCM). Finally, through bioinformatics analysis and experimental verification, potential strategies to bolster the anti-tumor immune response were investigated.ResultsIn comparison to the administration of 20Gy alone to the primary tumor, supplementing with 6Gy directed at the abscopal tumor produces a more pronounced abscopal response. The synergy of 20Gy, 6Gy, and ICIs markedly boosts the efficiency of ICIs. According to the findings from IHC and FCM studies, the triple therapy group exhibits a heightened infiltration of immune cells into the tumor, largely attributable to the augmented expression of CCL17 within the tumor under these irradiation regimens, which subsequently draws CD8+ T cells to infiltrate the tumor site, exerting cytotoxic effects.ConclusionOur study shows that the combined application of 20Gy and 6Gy can enhance the infiltration of tumor CD8+T cells in mice and improve the effectiveness of immunotherapy.