bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rh(III)‐Catalyzed Oxidative Annulation of 2‐Arylquinoxalines with Cyclic 2‐Diazo‐1,3‐diketones by C−H Bond Activation
Authors: Ajay Chidrawar , Yogananda Chary Devulapally , Balasubramanian Sridhar , Subba Reddy Basi V. 
Published: February 2023

AbstractRh(III)‐catalyzed C−H bond annulation of 2‐arylquinoxalines with cyclic 2‐diazo‐1,3‐diketones has been accomplished for the first time to synthesize a novel series of 2,3‐dihydrodibenzo[a,c]phenazin‐4(1H)‐one frameworks by means of carbene insertion followed by condensation. The reaction proceeds through the C−H bond activation and functionalization of 2‐arylquinoxalines using Rh(III)/AgSbF6 complex to produce highly substituted 2,3‐dihydrodibenzo[a,c]phenazin‐4(1H)‐one and benzo[5,6][1,2,4]thiadiazino[2,3‐f]phenanthridin‐5(6H)‐one‐10,10‐dioxide derivatives in good to excellent yields.
The effect of soursop‐flower‐enriched fried palm olein on some biochemical and hematological parameters of rats
Authors: Demgne Loungaing Valerie , Tonfack Djikeng Fabrice , Boungo Teboukeu Gires , Njike Ngamga Fabrice Herve , Womeni Hilaire Macaire 
Published: February 2023

AbstractThis work set out to, first, assess the role of soursop flower extracts (SFE) in limiting palm olein oxidation during the production of plantain chips, before ascertaining the effect of these soursop‐flower‐enriched fried palm olein on some biochemical and hematological parameters of rats. The extracts were added to 1.5 kg of oil at 1000, 1400, and 1800 ppm, while BHT at 200 ppm served as a positive control (PO+BHT), and the oil without additives was the negative control (PO). The samples were subjected to 15 frying cycles. Total oxidation values varied between 5.94 ± 0.0 and 31.58 ± 0.37; 8.08 ± 0.25 and 28.24 ± 0.00 and 13.71 ± 0.24 and 42.71 ± 0.40 respectively for palm olein enriched with SFE, for PO+BHT and for PO. Twenty‐one groups each comprising five rats received, through dietary supplementation, oils subjected to 0, and 5, 10 and 15 frying cycles for a duration of 30 days. The alanine transaminase and aspartate transaminase of rats fed with oils enriched with SFE at fresh states and at 5 frying cycles was comparable to that of the neutral control group (23.45 ± 2.65 and 93.10 ± 3.53 U/L) and lower than that of the negative control group (52.15 ± 2.01 and 124.07 ± 1.89 U/L). The HDL cholesterol of these animals was also comparable to that of the neutral control group (67.82 ± 4.06 mg/dl) and higher than that of the negative control group (50.25 ± 5.20 mg/dl). White blood cells and mean corpuscular volume of rats fed with fried olein previously enriched with SFE were lower than those fed with fried olein without additives. These extracts are recommended as natural antioxidants for the stabilization of palm olein.
Analyzing soft tissue stiffness of human upper arms during physical dynamic and quasi‐static impacts in human–machine interaction
Authors: Rajaei Nader , Fujikawa Tatsuo , Yamada Yoji 
Published: February 2023

AbstractKnowledge of the changes in the behavior of human soft tissue stiffness during physical impact in human–machine interaction (HMI) plays a vital role in the development of biofidelity testing devices such as a human dummy. These testing devices are widely applied as an effective means to validate the safety of machinery during dynamic or static contact with humans in HMI. In this study, we assess changes in soft tissue stiffness in the upper arm of individuals under both dynamic (0.7 and 0.25 m/s) and quasi‐static (QS) impacts under a constrained contact condition. Three impactor shapes (cylindrical, cubic, and spherical) are used in this study. Impact experiments are conducted using impactors attached to a pendulum. The soft‐tissue displacement is determined using an ultrasound device. The impact force‐displacement curves illustrate the nonlinear behavior of the soft tissue stiffness under both dynamic and QS impacts. By utilizing the “Linear Mixed Model” statistical analysis, we found that changes in the impact velocity significantly influenced the changes in the nonlinear behavior of soft tissue stiffness while there was no significant effect of the changes in the impactor shape on the nonlinear behavior of the soft tissue stiffness. Additionally, we revealed that the changes in the soft tissue stiffness are influenced by the size of the contact area. Moreover, we demonstrated a range of changes in soft tissue stiffness for different impact velocities, which provide valuable information for developing future validation test devices in HMI, such as the design and evaluation of dummy skin.
Effect of metal and polycyclic aromatic hydrocarbon contamination on soil organic carbon storage in semiarid areas
Authors: Jahantab Esfandiar 
Published: February 2023

AbstractMetal and polycyclic aromatic hydrocarbon (PAH) contamination severely influences the carbon storage potential of the biosphere. This study was conducted to investigate the changes in soil organic carbon (SOC) under metal and PAH contamination in the industrial area of Shiraz, Iran, over a period of 5 years. Canonical correspondence analysis and linear correlation analysis were performed to identify the relationship between metals, PAHs, vegetation and SOC. The results showed that both metals and PAHs significantly reduced SOC (p < 0.001). Metals played a more important role in SOC changes than PAHs by changing the vegetation characteristics. Increasing concentrations of ∑PAH (R2 = 0.33), phenanthrene (R2 = 0.36) and naphthalene (R2 = 0.42) were directly related to decreasing SOC. Additionally, the metals copper (Cu), lead (Pb), strontium (Sr), vanadium (V), chromium (Cr) and zinc (Zn) with the highest enrichment factor (EF; i.e. Pb = 5.42) had a negative correlation with SOC (R2 = 0.77). In general, metal contamination was more visible than PAH contamination and severely reduced the SOC. Overall, the management and filtration of polluting sources can prevent vegetation decline from reducing the SOC.
Increased Bone Formation and Accelerated Bone Mass Accrual in a Man Presenting with Diffuse Osteosclerosis/High Bone Mass Phenotype and Adenocarcinoma of Unknown Primary
Authors: Diamond Terrence H. , Bryant Carl , Quinn Richard , Mohanty Sindhu T. , Bonar Fiona , Baldock Paul A. , McDonald Michelle M. 
Published: February 2023

ABSTRACTA 71‐year‐old man was referred for evaluation of incidental generalized osteosclerosis. He was found to have a high bone mass (HBM) with an elevated lumbar spine bone mineral density (BMD) Z‐score of +5.3. Over an 18‐month period, his lumbar spine BMD measured by dual energy X‐ray absorptiometry (DXA) had increased by +64% from 1.09 to 1.79 g/cm2 and femoral neck by +21% from 0.83 to 1.01 g/cm2. Biochemical markers of bone turnover were markedly increased (serum propeptide of type 1 collagen and urine telopeptides greater than 10‐times normal). The high bone formation and increased skeletal calcium acquisition resulted in profound hypocalcemia (low serum calcium 1.88 mmol/L) and hypocalciuria (low urinary calcium <0.2 mmol/day). Positron emission tomography (PET) with 2‐deoxy‐2‐[fluorine‐18] fluoro‐D‐glucose (FDG) confirmed diffuse osteosclerosis without focal areas of abnormal FDG uptake in the skeleton or elsewhere to suggest either an underlying primary malignancy or metastatic disease. Bone biopsy showed markedly sclerotic woven and lamellar bone. The marrow space was devoid of typical bone cells and adipocytes and instead was filled by fibromyxoid stroma, infiltrated by small clusters of tumor cells. Bone histomorphometry and micro–computed tomography demonstrated an elevated trabecular bone volume and trabecular plate thickness. The bone disorder in this case is unique and raises the possibility of a new yet undefined novel anabolic paracrine factor (or factors) secreted by an adenocarcinoma of unknown primary that resulted in dramatic increases in BMD, HBM, and radiological osteosclerosis. The differential diagnosis and potential mechanisms responsible for the HBM are discussed. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Weighing the Evidence for the Roles of Plasma Versus Local Pyrophosphate in Ectopic Calcification Disorders
Authors: Ralph Douglas , Levine Michael , Millán José Luis , Uitto Jouni , Li Qiaoli 
Published: February 2023

ABSTRACTEctopic calcification is characterized by inappropriate deposition of calcium mineral in nonskeletal connective tissues and can cause significant morbidity and mortality, particularly when it affects the cardiovascular system. Identification of the metabolic and genetic determinants of ectopic calcification could help distinguish individuals at the greatest risk of developing these pathological calcifications and could guide development of medical interventions. Inorganic pyrophosphate (PPi) has long been recognized as the most potent endogenous inhibitor of biomineralization. It has been intensively studied as both a marker and a potential therapeutic for ectopic calcification. Decreased extracellular concentrations of PPi have been proposed to be a unifying pathophysiological mechanism for disorders of ectopic calcification, both genetic and acquired. However, are reduced plasma concentrations of PPi a reliable predictor of ectopic calcification? This perspective article evaluates the literature in favor and against a pathophysiological role of plasma versus tissue PPi dysregulation as a determinant of, and as a biomarker for, ectopic calcification. © 2023 American Society for Bone and Mineral Research (ASBMR).
Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway
Authors: Li Xiaoying , Zhou Li , Wang Ruike , Zhang Yangnan , Li Wei 
Published: February 2023

AbstractDeregulation of epidermal growth factor receptor (EGFR) signaling is frequently observed in non‐small cell lung cancer (NSCLC). The present study aimed to determine the impact of dihydromyricetin (DHM) on NSCLC, a natural compound extracted from Ampelopsis grossedentata with various pharmacological activities. Results of the present study demonstrated that DHM may act as a promising antitumor agent for NSCLC therapy, inhibiting the growth of cancer cells in vitro and in vivo. Mechanistically, results of the present study demonstrated that exposure to DHM downregulated the activity of wild‐type (WT) and mutant EGFRs (mutations, exon 19 deletion, and L858R/T790M mutation). Moreover, western blot analysis indicated that DHM induced cell apoptosis via suppression of the antiapoptotic protein, survivin. Results of the present study further demonstrated that depletion or activation of EGFR/Akt signaling may regulate survivin expression though modulating ubiquitination. Collectively, these results suggested that DHM may act as a potential EGFR inhibitor, and may provide a novel choice of treatment strategy for patients with NSCLC.
Meta‐analysis of culturally adapted cognitive behavioral therapy for anxiety and depression
Authors: Silveus Sarah A. , Schmit Michael K. , Oliveira Joy Teles , Hughes Lindsey E. 
Published: February 2023

AbstractIn this meta‐analysis, we synthesized 42 between‐group studies (N = 4114) evaluating the effectiveness of culturally adapted cognitive behavioral therapy (CA‐CBT) on reducing depression and anxiety severity when compared to waitlist/control groups and active alternative treatments. Separate random‐effects meta‐analyses revealed moderate‐to‐large effect sizes in favor of CA‐CBT on depression and anxiety when compared to active alternative treatments and waitlist/control groups. Independent random‐effects models revealed evidence of publication bias and indicated influential moderating effects on anxiety. Implications for counselor practice are discussed.
Exploring the role of a multidisciplinary hereditary gynecologic oncology clinic in epithelial ovarian cancer risk‐reducing surgical decision‐making practices: A mixed‐methods study
Authors: Casalino Selina , Bruce Sharon , Serfas Kim , Altman Alon D. , Kean Sarah , Lambert Pascal , McManus Kirk J. , Hartley Jessica N. , Nachtigal Mark W. 
Published: February 2023

AbstractIndividuals that have gynecologic reproductive organs with pathogenic variants in BRCA1 or BRCA2 (“BRCA‐positive”) have an increased risk of developing high‐grade serous ovarian cancer (HGSOC). The majority of HGSOC develops in the fallopian tubes and later spreads to the ovaries and peritoneal cavity. Therefore, risk‐reducing salpingo‐oophorectomy (RRSO) is recommended for those who are BRCA‐positive to preventatively remove their ovaries and fallopian tubes. The Hereditary Gynecology Clinic (HGC) is a provincial program in Winnipeg, Canada, that specifically targets care to the unique needs of such individuals through an interdisciplinary team of gynecological oncologists, menopause specialists, and registered nurses. A mixed‐methods study design was used to explore the decision‐making processes of these BRCA‐positive individuals who have been recommended (or who completed) RRSO and experiences with healthcare providers at the HGC influenced this decision. Individuals who are BRCA‐positive without a previous diagnosis of HGSOC and who had previously received genetic counselling were recruited from the HGC and the provincial cancer genetics program (Shared Health Program of Genetics & Metabolism). Forty‐three people completed a survey and 15 participated in an in‐depth interview about their experiences and decisions surrounding RRSO. Surveys were analyzed to compare scores on validated scales related to decision‐making and cancer‐related worry. Qualitative interviews were transcribed, coded, and analyzed using interpretive description. Participants described the complex decisions faced by those who are BRCA‐positive, which are intertwined with life experiences and circumstances including age, marital status, and family disease history. Participants interpreted their HGSOC risk through a personalized “lens” of contextual factors that impacted perceptions about the practical and emotional implications of RRSO and the need for surgery. Mean scores on validated scales evaluating the HGC's impact on decisional outcomes and preparedness for decision‐making about RRSO were not significant, indicating that the HGC played a supportive role, rather than helping with decision‐making itself. Therefore, we present a novel framework that consolidates the various influences on decision‐making and connects them to the psychological and practical implications of RRSO in the context of the HGC. Strategies for improving support, decisional outcomes, and the overall experiences of individuals who are BRCA‐positive attending the HGC are also described.
Ubiquity of graphs with nowhere‐linear end structure
Authors: Bowler Nathan , Elbracht Christian , Erde Joshua , Gollin J. Pascal , Heuer Karl , Pitz Max , Teegen Maximilian 
Published: February 2023

AbstractA graph is said to be ‐ubiquitous, where is the minor relation between graphs, if whenever is a graph with for all , then one also has , where is the disjoint union of many copies of . A well‐known conjecture of Andreae is that every locally finite connected graph is ‐ubiquitous. In this paper we give a sufficient condition on the structure of the ends of a graph which implies that is ‐ubiquitous. In particular this implies that the full‐grid is ‐ubiquitous.
Deep Learning Approach for MRI in the Classification of Anterior Talofibular Ligament Injuries
Authors: Ni Ming , Chen Wen , Zhao Qiang , Zhao Yuqing , Yuan Huishu 
Published: February 2023

BackgroundDiagnosing anterior talofibular ligament (ATFL) injuries differs among radiologists. Further assessment of ATFL tears is valuable for clinical decision‐making.PurposeTo establish a deep learning method for classifying ATFL injuries based on magnetic resonance imaging (MRI).Study TypeRetrospective.PopulationOne thousand seventy‐three patients from a single center with ankle MRI within 1 month of reference standard arthroscopy (in‐group dataset), were divided into training, validation, and test sets in a ratio of 8:1:1. Additionally, 167 patients from another center were used as an independent out‐group dataset.Field Strength/SequenceFat‐saturation proton density‐weighted fast spin–echo sequence at 1.5/3.0 T.AssessmentPatients were divided into normal, strain and degeneration, partial tear and complete tear groups (groups 0–3). The complete tear group was divided into five sub‐groups by location and the potential avulsion fracture (groups 3.1–3.5). All images were input into AlexNet, VGG11, Small‐Sample‐Attention Net (SSA‐Net), and SSA‐Net + Weight Loss for classification. The results were compared with four radiologists with 5–30 years of experience.Statistical TestsModel performance was evaluated by the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), and so on. McNemar's test was used to compare performance among the different models, and between the radiologists and models. The intraclass correlation coefficient (ICC) was used to assess the reliability of the radiologists. P < 0.05 was considered statistically significant.ResultsThe average AUC of AlexNet, VGG11, SAA‐Net, and SSA‐Net + Weight Loss was 0.95, 0.99, 0.99, 0.99 in groups 0–3 and 0.96, 0.99, 0.99, 0.99 in groups 3.1–3.5. The effect of SSA‐Net + Weight Loss was similar to SSA‐Net but better than AlexNet and VGG11. In the out‐group test set, the AUC of SSA‐Net + Weight Loss ranged from 0.89 to 0.99. The ICC of radiologists was 0.97–1.00. The effect of SSA‐Net + Weight Loss was better than each radiologist in the in‐group and out‐group test sets.Data ConclusionDeep learning has potential to be used for classifying ATFL injuries. SSA‐Net + Weight Loss has a better diagnostic effect than radiologists with different experience levels.Level of Evidence4Technical EfficacyStage 2
Kinetic studies on the persulfate oxidation of methylene blue in the absence and presence of silver(I) as a catalyst in aqueous and micellar media
Authors: Ewais Hassan A. , Basaleh Amal S. , Al Angari Yasser M. 
Published: February 2023

AbstractThe kinetics and mechanism of the oxidative decolorization of methylene blue (MB+) as a cationic dye by persulfate using silver(I) catalyst in aqueous acidic medium were studied. The effects of different parameters like [H+], [Ag+], reactant concentration, micelles, and temperatures were investigated. The kinetic data showed that the oxidative decolorization of [MB]+ by persulfate obeyed pseudo‐first‐order kinetics by taking a large excess of [S2O82−] over [MB+]. The observed rate constant increases with increasing of [H+]. A plausible mechanism for the silver(I) enhanced decolorization of [MB]+ by persulfate is suggested which is consistent with the experimental rate law. The effect of micelles such as SDS and Triton X‐100 on the reaction rate is investigated. The rate of reaction decreases with increasing [SDS] but is not affected by Triton X‐100. The mechanism of the electron transfer process between [MB]+ and S2O82– proceeds through an outer‐sphere mechanism. Thermodynamic activation parameters ΔH* and ΔS* were calculated. The experimental data may be useful for the layout of wastewater treatment containing various types of dyes.
Remote sensing of grasslands in the South American Pampas (scientometrics analysis)
Authors: da Rocha Najila Souza , Veettil Bijeesh Kozhikkodan , Ward Raymond David , Costi Juliana , Rolim Silvia Beatriz Alves 
Published: February 2023

AbstractRemotely sensed data contains a range of information (spectral, spatial, radiometric, and temporal) useful in mapping and monitoring grassland extent, minimizing the cost of field data collection and laboratory analysis, thereby improving management and conservation of these ecosystems. The South American pampa biome is one of the most productive ecosystems in the world consisting of an evergreen grassland environment in the southern areas of the continent (Brazil, Uruguay, and Argentina). In this review paper, a scientometrics analysis of the applications of grassland remote sensing in the South American pampa biome was performed with Web of Science Collection data using the relationship between authors/co‐authors, institutions, countries, and keywords. Despite a large number of published works on the application of remote sensing in grassland ecosystems, comparatively, few have been conducted in the South American pampa biome. Of 166 published articles on remote sensing of grassland systems, the first one published on the pampas was in 1995, while research on this topic has been going on since 1985 in the rest of the world. Recently, some Journals have demonstrated interest in remote sensing of the pampa region: (a)IEEE Journal of Selected Topics in Applied Earth, (b) ISPRS Journal of Photogrammetry and Remote Sensing, and (c) Science of The Total Environment. A number of remote sensing methods applied elsewhere have yet to be applied in the South American Pampas, including LiDAR applications. A wide range of grassland parameters that can be estimated using remote sensing includes ecosystem health, alien species invasion, and biomass.
Image analysis and benthic ecology: Proceedings to analyze in situ long‐term image series
Authors: Alicia Romero‐Ramirez , Laura Morales Luna Hadrys , Piotr Kuklinski , Maciej Chelchowski , Piotr Balazy 
Published: February 2023

AbstractLong time series of underwater images have become a tool widely used within the benthic ecology research community. The development of new acquisition systems with bigger storing capacities lead researchers and scientists to deploy them for longer periods resulting in large amounts of data. This paper focuses on the first steps of analyzing large numbers of underwater images, which involves assessing the amount of valid data while assuming no technical problems. The question here addressed is how many of the in situ images can reliably be really used for benthic ecology purposes. To answer this question, we propose a method to eliminate nonvalid images and use it with four different sets of time‐lapsed images acquired for long periods ranging from 73 to 371 ds in a row. The results show that elimination of between 8% and 22% of the images is possible depending on the data set. The main advantage of the method is easing and accelerating automation of subsequent analysis.
Surface Modification of Polydimethylsiloxane via Combined Aminolysis and Alcoholysis Generating Cell Adhesive and Antifouling Properties
Authors: Gabriel Matthias , Raynaud Christophe Michel , Bollensdorff Christian 
Published: February 2023

AbstractPolydimethylsiloxane (PDMS) is an elastomeric polymer frequently used as implant material, for flexible tubing and in microfluidic devices. The pronounced hydrophobic surface of this unique material impedes many applications where a good wetting behavior is required. Consequentially, various ways of surface modifications have been used to introduce new properties. Plasma treatment is the most popular technique in this respect, but is not generally applicable, especially if hardly accessible surfaces are to be modified. A novel wet‐chemistry‐based modification scheme yielding an amino‐functionalized PDMS surface using a combined alcoholysis/aminolysis reaction is presented. Biological applications are exemplified by the conjugation of the RGD peptide, or polyethylene glycol (PEG) and heparin, yielding surfaces with cell‐adhesive or nonthrombogenic properties, respectively. The effect of subsequent conjugation with an adhesive peptide is tested in cell culture. Additionally, two antifouling surfaces generated by coupling heparin and polyethylene glycol respectively are shown to improve the materials resistance to platelet adhesion drastically while simultaneously preventing hydrophobic recovery of the PDMS surface. The findings provide a versatile means of surface functionalization of PDMS substrates and is suitable for many biomedical applications.