bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluoroscopy-guided aspiration of the acutely dislocated total hip arthroplasty: a feasible, high-yield, and safe procedure
Authors: Flores Dyan V. , Felemban Abdullah , Hodgdon Taryn , Beaulé Paul , Grammatopolous George , Rakhra Kawan S. 
Published: January 2025

Abstract
Objective
To determine the feasibility, yield, and safety of fluoroscopic-guided aspiration of the acutely dislocated total hip arthroplasty (AD-THA).

Materials and methods
IRB-approved, retrospective review of fluoroscopic-guided aspirations of AD-THA (January 2005–December 2023) was performed. Data from electronic charts and fluoroscopy images/reports were obtained. Positive yield was defined as spontaneous aspirate or saline rinse adequate for microbiology analysis. Sub-analysis by needle target (acetabular cup or femur) was performed for spontaneous aspiration rate, aspirate volume and fluoroscopy time. Differences between groups were analyzed with unpaired, t-test (2-tail) and between proportions with Fisher’s exact test, with significance p < 0.05.

Results
Aspiration of 20 AD-THA in 19 patients (12 female, mean age (SD) of 73 years (16)) targeted the acetabular cup in 45% (9/20) or femur in 55% (11/20) of cases. Positive yield was obtained in 95% (19/20), with spontaneous aspirate in 75% (15/20) and saline rinse in 20% (4/20) of cases; in 5% (1/20), no diagnostic sample was obtained. Spontaneous aspirate mean volume (SD, range) for all cases was 8.3 mL (6.9, 0.2–25), and higher when targeting the acetabular cup 11.2 mL (6.9, 5–25) versus the femur 4.0 mL (4.4, 0.2–12) (p = 0.026). The rate of spontaneous aspiration was higher for the acetabular cup 100% (9/9) versus the femur 55% (6/11) (p = 0.038). The mean fluoroscopy time (SD, range) for all cases was 43 s (25, 19–102), and shorter for targeting the acetabular cup 32 s (16, 19–75) versus the femur 56 s (28, 28–102) (p = 0.034). No immediate complications occurred in all aspirations.

Conclusion
Fluoroscopy-guided aspiration of AD-THA is a feasible, high-yield, and safe procedure. Targeting the acetabular cup results in a higher rate of spontaneous aspirate, larger aspiration volume, and lower fluoroscopy time.

Critical relevance statement
Although technically more challenging, radiologists should feel confident aspirating the acutely dislocated total hip arthroplasty (AD-THA) under fluoroscopic guidance.

Key Points

Total hip arthroplasty (THA) infection can be evaluated with synovial fluid aspiration.

Fluoroscopic-guided aspiration of the dislocated THA is feasible, high-yield, and safe.

Targeting of the acetabular cup is recommended over the femoral prosthetic component.

Acetabular cup targeting gives larger, spontaneous aspirates with lower fluoroscopy time.

Graphical Abstract
Ultra-low dose dual-layer detector spectral CT for pulmonary nodule screening: image quality and diagnostic performance
Authors: Ding Li , Chen Mingwang , Li Xiaomei , Wu Yuting , Li Jingxu , Deng Shuting , Xu Yikai , Chen Zhao , Yan Chenggong 
Published: January 2025

Abstract
Objectives
To investigate the image quality and diagnostic performance with ultra-low dose dual-layer detector spectral CT (DLSCT) by various reconstruction techniques for evaluation of pulmonary nodules.

Materials and methods
Between April 2023 and December 2023, patients with suspected pulmonary nodules were prospectively enrolled and underwent regular-dose chest CT (RDCT; 120 kVp/automatic tube current) and ultra-low dose CT (ULDCT; 100 kVp/10 mAs) on a DLSCT scanner. ULDCT was reconstructed with hybrid iterative reconstruction (HIR), electron density map (EDM), and virtual monoenergetic images at 40 keV and 70 keV. Quantitative and qualitative image analysis, nodule detectability, and Lung-RADS evaluation were compared using repeated one-way analysis of variance, Friedman test, and weighted kappa coefficient.

Results
A total of 249 participants (mean age ± standard deviation, 50.0 years ± 12.9; 126 male) with 637 lung nodules were included. ULDCT resulted in a significantly lower mean radiation dose than RDCT (0.3 mSv ± 0.0 vs. 3.6 mSv ± 0.8; p < 0.001). Compared with RDCT, ULDCT EDM showed significantly higher signal-noise-ratio (44.0 ± 77.2 vs. 4.6 ± 6.6; p < 0.001) and contrast-noise-ratio (26.7 ± 17.7 vs. 5.0 ± 4.4; p < 0.001) with qualitative scores ranked higher or equal to the average. Using the regular-dose images as a reference, ULDCT EDM images had a satisfactory nodule detection rate (84.6%) and good inter-observer agreements compared with RDCT (κw > 0.60).

Conclusion
Ultra-low dose dual-layer detector CT with 91.2% radiation dose reduction achieves sufficient image quality and diagnostic performance of pulmonary nodules.

Critical relevance statement
Dual-layer detector spectral CT enables substantial radiation dose reduction without impairing image quality for the follow-up of pulmonary nodules or lung cancer screening.

Key Points

Radiation dose is a major concern for patients requiring pulmonary nodules CT screening.

Ultra-low dose dual-layer detector spectral CT with 91.2% dose reduction demonstrated satisfactory performance.

Dual-layer detector spectral CT has the potential for lung cancer screening and management.

Graphical Abstract
Estimated prevalence of post-intensive care cognitive impairment at short-term and long-term follow-ups: a proportional meta-analysis of observational studies
Authors: Ho Mu-Hsing , Lee Yi-Wei , Wang Lizhen 
Published: January 2025

Abstract
Objective
Evidence of the overall estimated prevalence of post-intensive care cognitive impairment among critically ill survivors discharged from intensive care units at short-term and long-term follow-ups is lacking. This study aimed to estimate the prevalence of the post-intensive care cognitive impairment at time to < 1 month, 1 to 3 month(s), 4 to 6 months, 7–12 months, and > 12 months discharged from intensive care units.

Methods
Electronic databases including PubMed, Cochrane Library, EMBASE, CINAHL Plus, Web of Science, and PsycINFO via ProQuest were searched from inception through July 2024. Studies that reported on cognitive impairment among patients discharged from intensive care units with valid measures were included. Data extraction and risk of bias assessment were performed independently for all included studies according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guidelines. Newcastle–Ottawa Scale was used to measure risk of bias. Data on cognitive impairment prevalence were pooled using a random-effects model. The primary outcome was pooled estimated proportions of prevalence of the post-intensive care cognitive impairment.

Results
In total, 58 studies involving 347,940 patients were included. The pooled post-intensive care cognitive impairment prevalence rates at the follow-up timepoints < 1 month, 1–3 month(s), 4–6 months, 7–12 months, > 12 months were 49.8% [95% Prediction Interval (PI), 39.9%–59.7%, n = 19], 45.1% (95% PI, 34.8%–55.5%, n = 23), 47.9% (95% PI, 35.9%–60.0%, n = 16), 28.3% (95% PI, 19.9%–37.6%, n = 19), and 30.4% (95% PI, 18.4%–43.9%, n = 7), respectively. Subgroup analysis showed that significant differences of the prevalence rates between continents and study designs were observed.

Conclusions
The prevalence rates of post-intensive care cognitive impairment differed at different follow-up timepoints. The rates were highest within the first three months of follow-up, with a pooled prevalence of 49.8% at less than one month, 45.1% at one to three months, and 47.9% at three to six months. No significant differences in prevalence rates between studies that only included coronavirus disease 2019 survivors. These fundings highlight the need for further research to develop targeted interventions to prevent or manage cognitive impairment at short-term and long-term follow-ups.
A protocol to study the effect of targeted parental education intervention to identify early childhood development disorder – multisite interventional study
Authors: Kanniappan Vadivelan , Muthuperumal Prakash , Venkataraman P. , Murugesan Anuradha , Chinnasami Balaji , Muthiah Manikumar , Sethuraman Subramanian , J. R. Abishek , Suresh Shrisruthi , Nambirajan Murali Krishnan , G. Angeline Grace , T. S. Veeragoudhaman , Deivasigamani Kuberan 
Published: January 2025

Abstract
Background
In India, approximately 3.5 million children are affected by Developmental Delay (DD), often stemming from preterm births. These delays contribute to neurological and motor development delays, placing a significant financial burden on families. Maternal unemployment rates are also elevated in such cases. Delayed Developmental Milestones identification, often due to a lack of parental awareness, further compounds these challenges. This study introduces a multiphasic approach aimed at educating antenatal women on monitoring neurological maturation, with the overarching objective of assessing the effectiveness of a targeted multi-method parental education intervention in improving parents’ knowledge and early detection of developmental disorders in early childhood.

Methods
Antenatal women will be assigned to intervention or control groups. The intervention group will undergo specialized training in a multiphasic study, while the control group will receive routine care. A meticulously developed intervention module for early detection of neurodevelopmental disorders will empower mothers to monitor their newborns for potential deficits. Outcomes will be assessed through questionnaires, analyzing knowledge improvement and early identification of DD using statistical methods such as chi-square tests. The study involves three phases: preparatory, implementation, and evaluation, aiming to empower mothers to detect developmental concerns early and improve maternal awareness of child development. The study was approved by the SRM Institutional Ethical Committee with the reference number 8688/IEC/2023.

Discussion
This study will identify DD and improve parental awareness by providing tools for early detection thereby empowers parents to identify developmental concerns early. The study supports policy goals to reduce the burden of DD, enhance early intervention, and improve long-term outcomes for children. It is anticipated that this intervention will complement existing health policies, contributing to better child health and developmental outcomes in India.

Trial registration
Trail is registered under Clinical Trails Registry - India (CTRI/2024/04/065008) registered on 01 April 2024.
Systematic review on the effects of exercise with and without breakfast consumption on cognitive performance in healthy adults
Authors: Hsieh Shu-Shih , Tian Yu , Cheng Chun-Yuan , Chen Yung-Chih 
Published: January 2025

Abstract
Background
The objective of this systematic review was to review the current evidence on the effects of acute exercise with and without morning breakfast consumption on cognitive performance.

Methods
This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines and is registered in the International Prospective Register of Systematic Reviews (CRD42023396125). Studies were included if they investigated effects of acute exercise with and without preceding morning breakfast on cognitive performance measured during and following exercise in healthy adults. Eligible studies from 5 electronic databases, PubMed, Scopus, MEDLINE, Web of Science, and Embase, with no limitations on years and dates of publications to retrieve maximal number of literature (literature search and screen were completed on 13 December 2024). Study quality was assessed using the Physiotherapy Evidence Database scale (PEDro).

Results
A total of 3018 studies were screened. Five studies, involving 70 participants (42 women, aged between 18 and 50 years) in total (sample size per study: 10–24), were eligible for inclusion in this review. The synthesised results based on 5 identified studies with healthy adults showed that there was no indication that effects of exercise on cognitive performance (e.g., processing speed, inhibitory control) are altered by breakfast skipping and/or consumption (e.g., different portion, macronutrients, and contents). The included studies had a mean PEDro score of 4.0 (scored between 3 and 5), suggesting ‘fair’ methodological quality.

Conclusion
The synthesised results showed that there was no indication that effects of exercise on cognitive performance (e.g., processing speed, inhibitory control) are altered by morning breakfast consumption or macronutrients and contents of breakfast in healthy adults. However, the synthesised results should be interpreted cautiously, given the limited evidence and the heterogeneity in methodology with mostly involved young and healthy adults. Further investigation regarding interactive effects of breakfast and exercise on cognition, especially in individuals with metabolic disease or medical conditions, is warranted.
The periplasmic protein HslJ is the first-line of defense against oxidative stress in Acinetobacter baumannii
Authors: Scribano Daniela , Pasqua Martina , Limongi Dolores , Nencioni Lucia , Palamara Anna Teresa , Ambrosi Cecilia 
Published: January 2025

Abstract

Background

Acinetobacter baumannii poses a significant threat globally, causing infections primarily in healthcare settings, with high mortality rates. Its adaptability to antibiotic resistance and tolerance to various stresses, including reactive oxygen species (ROS), contribute to its persistence in healthcare environments. Previous evidence suggested that the periplasmic heat shock protein, HslJ-like protein (ABUW_2868), could be involved in oxidative stress defense in A. baumannii. In this study, we demonstrate the pivotal function of HslJ as the first line of defense against oxidative damage induced by hydrogen peroxide (H2O2).

Methods
An isogenic site-specific hslJ mutant of A. baumannii AB5075 was used to evaluate its sensitivity to H2O2, survival rate in human macrophages, biofilm, cell surface hydrophobicity, and motility. Additionally, the hslJ expression profile was measured under stress conditions and its OxyR-dependent regulation was assessed both in vitro and in a heterologous host.

Results
Herein, we report that HslJ is under the positive regulatory control of OxyR, which upregulates its expression in response to imipenem (IMP) and H2O2, thereby underscoring its importance in A. baumannii survival strategy. In addition, our findings revealed that the hslJ mutant displayed abrogated surface-associated motility accompanied by increased cell surface hydrophobicity (CSH), indicating also a role in maintaining cell membrane properties.

Conclusions
This comprehensive understanding of HslJ multifaceted role not only enriches our knowledge of A. baumannii stress response mechanisms but also provides valuable insights for developing targeted strategies to eradicate this deadly resilient pathogen in healthcare settings.
Monetary policy shocks and multi-scale positive and negative bubbles in an emerging country: the case of India
Authors: Cepni Oguzhan , Gupta Rangan , Nel Jacobus , Nielsen Joshua 
Published: January 2025

AbstractWe employ the Multi-Scale Log-Periodic Power Law Singularity Confidence Indicator (MS-LPPLS-CI) approach to identify positive and negative bubbles in the short-, medium, and long-term for the Indian stock market, using weekly data from November 2003 to December 2020. We use a nonparametric causality-in-quantiles approach to analyze the predictive impact of monetary policy shocks on bubble indicators. We find, in general, strong evidence of predictability across the entire conditional distribution for the two monetary policy shock factors, with stronger impacts for negative bubbles. Our findings have critical implications for the Reserve Bank of India, academics, and investors.
Harmonized technical standard test methods for quality evaluation of medical fluorescence endoscopic imaging systems
Authors: Liu Bodong , Guo Zhaojun , Yang Pengfei , Ye Jian’an , He Kunshan , Gao Shen , Chi Chongwei , An Yu , Tian Jie 
Published: January 2025

AbstractFluorescence endoscopy technology utilizes a light source of a specific wavelength to excite the fluorescence signals of biological tissues. This capability is extremely valuable for the early detection and precise diagnosis of pathological changes. Identifying a suitable experimental approach and metric for objectively and quantitatively assessing the imaging quality of fluorescence endoscopy is imperative to enhance the image evaluation criteria of fluorescence imaging technology. In this study, we propose a new set of standards for fluorescence endoscopy technology to evaluate the optical performance and image quality of fluorescence imaging objectively and quantitatively. This comprehensive set of standards encompasses fluorescence test models and imaging quality assessment protocols to ensure that the performance of fluorescence endoscopy systems meets the required standards. In addition, it aims to enhance the accuracy and uniformity of the results by standardizing testing procedures. The formulation of pivotal metrics and testing methodologies is anticipated to facilitate direct quantitative comparisons of the performance of fluorescence endoscopy devices. This advancement is expected to foster the harmonization of clinical and preclinical evaluations using fluorescence endoscopy imaging systems, thereby improving diagnostic precision and efficiency.
Advances in oral dissolving film research in the food field
Authors: Li Yue , Zhao Min , Zhao Ming-Yue , Li Bin , Tian Jin-Long 
Published: January 2025

AbstractOral dissolving film (ODF) emerges as a novel active substance delivery system, offering portability, safety, and compliance. ODF presents superior gastrointestinal absorption compared to conventional food products, making it ideal for providing nutrition and medication support to vulnerable populations such as children, the elderly, and individuals with dysphagia. With promising applications in pharmaceuticals and especially food industry, ODFs offer a highly absorbable method for delivering nutritious and healthy foods. This review underscores the potential of orally dissolving films in active substance delivery, outlining their advantages over traditional oral delivery methods and their current market status. Additionally, the review discusses the formulation procedure, production methods, and quality evaluation methods for film dosage forms of ODFs. Lastly, it examines the limitations of ODFs and speculates on their future trends in the food industry. This study serves as a valuable reference for the development and utilization of orally dissolving films in the food sector.
Graphical Abstract
Twist deformation response of a holographic volume grating in flexible photopolymer
Authors: Liu Hongpeng , Lu Cheng , Sun Gaojing , Zhang Chen , Li Zihan , Li Li 
Published: January 2025

Twist deformation of flexible photopolymer
using a diffraction spectrum
of a holographic volume grating is explored. Twist deformation can be
categorized into transverse shear and macroscopic twist deformations.
At a small twist angle, the transverse shear deformation can be
considered as a tiny unit of twist deformation. In a transmission
grating, the peak wavelength shift exceeds 150 nm, which
provides a large linear measurement range of ±20deg and 0.08 deg/nm angular
sensitivity for sensing shear deformation. The sensitivity of the
reflection grating is significantly lower than that of the
transmission grating. The obvious change in the color of the
diffraction spot provides an important basis for visualization of
twist deformation. At a large twist angle, the macroscopic twist
deformation is characterized. The linear peak wavelength shift exceeds
120 nm, and the twist angle exceeds 100 deg. The optimal
angular sensitivity approaches 0.55 deg/nm. The relative
parameters confirm the applicability of a holographic grating
reflecting the macroscopic twist deformation. This research can
promote the practical application of holographic sensors in sensing
mechanical deformation of material, such as the measurement of the
pre-tightening force of bolts and other fields.
Use of patient-centred outcome measures alongside the personal wheelchair budget process in NHS England: A mixed methods approach to exploring the staff and service user experience of using the WATCh and WATCh-Ad
Authors: Tuersley Lorna , Quaye Naa Amua , Pisavadia Kalpa , Edwards Rhiannon Tudor , Bray Nathan 
Published: January 2025

Background and objective
Personal wheelchair budgets (PWBs) are offered to everyone in England eligible for a wheelchair provided through the National Health Service (NHS) to support their choice of equipment. The WATCh (Wheelchair outcomes Assessment Tool for Children) and related WATCh-Ad for adults are patient-centred outcome measures (PCOMs) developed to help individual users express their main outcome needs when obtaining a wheelchair and rate their satisfaction with subsequent outcomes after receiving their equipment. Use was explored in a real-world setting, aiming to produce guidance for use alongside the PWB process.

Methods
Three wheelchair service provider organisations across four sites participated. Staff and users completed surveys about their experience of assessments using the WATCh and/or WATCh-Ad. Selected patients were interviewed after receipt of their equipment, and staff were interviewed after experiencing a number of assessments. Thematic analysis was undertaken using the tool, survey and interview data. Results of pre- and post-equipment provision were presented graphically.

Results
Information on 75 assessments by 15 staff was obtained. Three-quarters of users or their carers rated the use of the tools in the assessment process as ‘helpful’ or ‘very helpful’. Staff reported that the WATCh or WATCh-Ad had been considered ‘useful’ in developing individual care plans in around 1 in 3 cases and affected the prescription in 1 in 4 cases. Concerns were expressed about the length of time taken to administer the tools in clinic. However, some staff noted this reduced with more hands-on experience and by providing the tools to users in advance of the appointment.

Conclusions
The WATCh and WATCh-Ad PCOMs are suitable for routine use by wheelchair service providers to assist the assessment process. It is recommended that tool materials are provided in advance to users/carers and that staff are allowed time to develop their ways of working with them.