bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression and Quality of Life among Urban Elderly in Dhaka City during the Covid-19 Pandemic
Authors: Mahmood Tarim , Mahmud Tasnim , Tripty Nabila Nusrat 
Published: August 2023

Objective: This study was conducted with the aim to determine whether there was any association between depression and quality of life among the urban elderly during the COVID-19 pandemic.
Methods: This study was conducted across some urban areas of Dhaka city namely Gulshan, Niketan and Mohakhali areas. 91 respondents aged 60 years and above residing in urban areas were interviewed once at one point in time. All the information was to be collected within the time frame. Hence the most appropriate study design in this case would be cross-sectional study design. The duration for the thesis work was 1 year, from 1st January to 31st December 2020. Method of sampling was convenient method of sampling. Data were collected by face-to-face interview and telephone interview.
Results: In case of clinical characteristics, elderly people aged 60 years and above participated. Mean age was 66.42 (SD± 5.106) years. Minimum and maximum age was respectively 60 years and 80 years. Among the 91 respondents, 48 (52.7%) were males and 43 (47.3%) were females. It is found that, 64 (70.3%) were married, 1 (1.1%) was unmarried, 24 (26.4%) were widowed, 2 (2.2%) were divorced. Of all the respondents, 34.1% were graduates and 24.2% were post graduates. Majority of respondents (84.6%) were the followers of Islam, followed by (11%) Hindus. Here, among the 91 respondents, some of them had only one disease, whereas some of them had more than one disease. To explain, 56 (31.8%) had Hypertension, 55 (31.3%) people had Diabetes Mellitus, 32 (18.2%) had cardiac problems, 13 (7.4%) suffered from stroke, 11 (6.3%) had chronic lung disease, 7 (4.0%) suffered from chronic kidney disease, 1 (0.6%) had cancer, and 1 (0.6%) had Alzheimer’s disease. In case of association between depression and psychological domain of quality of life, the highest mean score was found within those who had no depression (M=63.93), followed by mild depression (M=48.95), then moderate depression (M=40.71) and lastly severe depression (M=33.80). To see the impact of level of depression on psychological domain of quality of life, one-way between group ANOVA was conducted. There was statistically significant difference at p<0.05 in QOL for levels of depression: F (3, 87) = 14.019, p=0.00.
Race and Treatment Outcomes in Patients With Metastatic Castration-Sensitive Prostate Cancer
Authors: Sayegh Nicolas , Swami Umang , Jo Yeonjung , Gebrael Georges , Haaland Benjamin , Gupta Shilpa , Plets Melissa , Hussain Maha H. A. , Quinn David I. , Lara Primo N. , Thompson Ian M. , Agarwal Neeraj 
Published: August 2023

ImportanceBlack patients present with more aggressive disease and experience higher mortality than White patients with prostate cancer. Race and social determinants of health influence prostate cancer-specific mortality and overall survival (OS); however, in a previous trial, Black patients did not have inferior outcomes compared with White patients, possibly because of equitable access to care available in a clinical trial setting.ObjectiveTo compare differences in survival outcomes of patients with metastatic castration-sensitive prostate cancer (mCSPC) by race in a phase 3 trial with a large proportion of Black patients.Design, Setting, and ParticipantsThis secondary analysis of patient-level data of a prospective phase 3 randomized clinical trial included patients with newly diagnosed mCSPC enrolled between March 1, 2013, and July 15, 2017. Analysis was conducted between December 2022 and February 2023.InterventionsPatients receiving androgen deprivation therapy were randomized (1:1) to receive either orteronel 300 mg orally twice daily (experimental group) or bicalutamide 50 mg orally daily (control group).Main Outcomes and MeasuresOS, with progression-free survival (PFS) as a secondary end point.ResultsAmong 1313 participants, 135 (10%) identified as Black and 1077 (82%) as White, with an equal racial distribution between groups. Black patients were younger (median [IQR] age, 65.8 [60-70] vs 68.4 [62.5-74.1] years; P = .001) and had a higher median (IQR) baseline prostate-specific antigen response rate than White patients (54.7 [19.8-222.0] vs 26.7 [9.2-96.0] ng/mL; P &amp;lt; .001). At a median follow-up of 4.9 years, Black and White patients had similar median PFS (2.3 years; 95% CI, 1.8-1.4 years vs 2.9 years; 95% CI, 2.5-3.3 years; P = .71) and OS (5.5 years; 95% CI, 4.8-NR vs 6.3 years; 95% CI, 5.7-NR; P = .65). The multivariable analysis confirmed similar PFS and OS after adjusting for known prognostic factors. No interaction between race and treatment was observed.Conclusions and RelevanceIn this secondary analysis of a randomized clinical trial studying androgen deprivation therapy with first- or second-generation androgen receptor pathway inhibitors, both Black and White patients demonstrated similar OS and PFS. Equitable access to care may reduce historical differences in outcomes between Black and White patients with advanced prostate cancer.Trial RegistrationClinicalTrials.gov Identifier: NCT01809691
An Intensive 18F-Fludeoxyglucose–Positron Emission Tomography With Computed Tomography–Based Strategy of Follow-Up in Patients Treated for Head and Neck Squamous Cell Carcinoma Who Are Clinically Asymptomatic
Authors: Leclère Jean-Christophe , Clément Camille , Le Pennec Romain , Maheo Clementine , Gujral Dorothy M. , Schick Ulrike , Le Gal Grégoire , Marianowski Remi , Salaun Pierre-Yves , Abgral Ronan 
Published: August 2023

ImportancePatients with head and neck squamous cell carcinoma (HNSCC) have a significant risk of locoregional recurrence within the first 2 years, with approximately two-thirds of patients experiencing such recurrence. While early recurrence detection may be associated with improved patient outcomes, the association of such detection with survival remains uncertain.ObjectiveTo investigate the association of an intensive posttreatment follow-up strategy using 18F-fludeoxyglucose–positron emission tomography with computed tomography (18FDG-PET/CT) with survival among patients with HNSCC.Design, Setting, and ParticipantsThis case-control study was conducted among patients treated at 1 of 3 locations in Brest, France (University Hospital, Military Hospital, or Pasteur Clinic). The statistical analysis was conducted from January to June 2023. All adults with histologically proven HNSCC who were treated with curative intent between January 1, 2006, and December 31, 2019, and achieved a complete response on imaging at 3 to 6 months were included. They had a minimum of 3 years of follow-up.ExposuresPatients undergoing an intensive posttreatment follow-up strategy had 18FDG-PET/CT (PET/CT group) at months 12, 24, and 36, chosen at the discretion of ear, nose, and throat surgeons.Main Outcomes and MeasuresOverall survival (OS) at 3 years.ResultsAmong 782 patients with HNSCC (642 males [82.1%]; median [IQR] age, 61 [56-68] years), 497 patients had 18FDG-PET/CT during follow-up and 285 patients had conventional follow-up (CFU group). Cox regression analysis showed an association between undergoing 18FDG-PET/CT and lower risk of death (odds ratio, 0.71; 95% CI, 0.57-0.88; P = .002) after adjustment for covariates (age, sex, comorbidities, primary location, stage, surgeon, year of treatment, and treatment). The mean (SD) 3-year OS was significantly better in the PET/CT vs CFU group (72.5% [2.0%] vs 64.3% [2.9%]; P = .002). Analysis based on American Joint Committee on Cancer stage showed significantly better mean (SD) 3-year OS for advanced stages III and IV in the PET/CT group (373 patients) vs CFU group (180 patients; 68.5% [2.4%] vs 55.4% [3.8%]; P &amp;lt; .001), while no significant difference was observed between patients with stage I or II HNSCC. Analysis based on primary tumor site revealed significantly longer mean (SD) 3-year OS for oropharyngeal tumor in the PET/CT group (176 patients) than the CFU group (100 patients; 69.9% [3.5%] vs 60.5% [5.0%]; P = .04).Conclusions and relevanceThis case-control study found that use of 18FDG-PET/CT in the standard annual CFU of HNSCC was associated with a 3-year survival benefit, with a larger benefit for patients with advanced initial tumor stage (III-IV) and oropharyngeal disease.
A Redox Modulatory SOD Mimetic Nanozyme Prevents the Formation of Cytotoxic Peroxynitrite and Improves Nitric Oxide Bioavailability in Human Endothelial Cells
Authors: Geethika Motika , Singh Namrata , Kumar Sagar , Kumar Somanathapura K. Naveen , Mugesh Govindasamy 
Published: August 2023

AbstractThe endothelium‐derived signalling molecule nitric oxide (NO) in addition to controlling multifarious servo‐regulatory functions, suppresses key processes in vascular lesion formation and prevents atherogenesis and other vascular abnormalities. The conversion of NO into cytotoxic and powerful oxidant peroxynitrite (ONOO−) in a superoxide (O2.−)‐rich environment has emerged as a major reason for reduced NO levels in vascular walls, leading to endothelial dysfunction and cardiovascular complications. So, designing superoxide dismutase (SOD) mimetics that can selectively catalyze the dismutation of O2.− in the presence of NO, considering their rapid reaction is challenging and is of therapeutic relevance. Herein, the authors report that SOD mimetic cerium vanadate (CeVO4) nanozymes effectively regulate the bioavailability of both NO and O2.−, the two vital constitutive molecules of vascular endothelium, even in the absence of cellular SOD enzyme. The nanozymes optimally modulate the O2.− level in endothelial cells under oxidative stress conditions and improve endogenously generated NO levels by preventing the formation of ONOO−. Furthermore, nanoparticles exhibit size‐ and morphology‐dependent uptake into the cells and internalize via the clathrin‐mediated endocytosis pathway. Intravenous administration of CeVO4 nanoparticles in mice caused no definite organ toxicity and unaltered haematological and biochemical parameters, indicating their biosafety and potential use in biological applications.
Advancing Energy Harvesting Efficiency from a Single Droplet: A Mechanically Guided 4D Printed Elastic Hybrid Droplet‐Based Electricity Generator
Authors: Kam Dongik , Gwon Girak , Jang Sunmin , Yoo Donghyeon , Park Sung Jea , La Moonwoo , Choi Dongwhi 
Published: August 2023

AbstractA droplet possesses the ubiquity and potential to harvest a vast amount of energy. To exploit droplets effectively, a novel output enhancement strategy that can coexist and create synergy with the recently studied droplet‐based electricity generator (DEG) and material/surface structure modification must be investigated. In this study, a mechanical buckling‐based 4D printed elastic hybrid droplet‐based electricity generator (HDEG) consisting of a DEG and solid–solid triboelectric nanogenerator (S–S TENG) is first presented. During the electricity generation process of the DEG by droplet impact, the HDEG structure, which is merged via a simple 4D printing technique, permits the conversion of dissipated energy into elastic energy, resulting in an S–S TENG output. The HDEG outputs are naturally integrated owing to the simultaneous activation of a single droplet, resulting in an approximately 30% improvement over the output of a single DEG. Internal and external parametric studies are performed as HDEG design guidelines. The HDEG exhibits a 25% better energy supply performance than that of a single DEG, demonstrating its applicability as a power source. This research proposes the way toward a hybrid system that efficiently harvests energy from ubiquitous droplets.
Recent Progress of Quantum Dot Infrared Photodetectors
Authors: Wang Zan , Gu Yunjiao , Li Xiaoman , Liu Yan , Liu Fenghua , Wu Weiping 
Published: August 2023

AbstractInfrared (IR) technology plays a significant role in many application scenarios, such as satellite remote sensing, environmental monitoring, biomedical engineering, imaging, communications, and so on. Demands of the next generation IR photodetectors, including ease of fabricaation, low cost, high flexibility, and so on, greatly drive the development of colloidal IR quantum dots (QDs) as the most competitive candidate material for IR photodetectors. In this article, the progress of IR QD materials and photodetectors, the fundamentals of IR QDs, the integration of IR QDs with other materials for hybrid photodetectors, and the applications of the QD IR photodetectors are reviewed.
A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross‐Protection Activity against Multiple SARS‐CoV‐2 Sublineages
Authors: Zhang Xiantao , Wu Shijian , Liu Jie , Chen Ran , Zhang Yongli , Lin Yingtong , Xi Zhihui , Deng Jieyi , Pu Zeyu , Liang Chaofeng , Feng Jinzhu , Li Rong , Lin Keming , Zhou Mo , Liu Yingying , Zhang Xu , Liu Bingfeng , Zhang Yiwen , He Xin , Zhang Hui 
Published: August 2023

AbstractBecause of the rapid mutation and high airborne transmission of SARS‐CoV‐2, a universal vaccine preventing the infection in the upper respiratory tract is particularly urgent. Here, a mosaic receptor‐binding domain (RBD) nanoparticle (NP) vaccine is developed, which induces more RBD‐targeted type IV neutralizing antibodies (NAbs) and exhibits broad cross‐protective activity against multiple SARS‐CoV‐2 sublineages including the newly‐emerged BF.7, BQ.1, XBB. As several T‐cell‐reactive epitopes, which are highly conserved in sarbecoviruses, are displayed on the NP surface, it also provokes potent and cross‐reactive cellular immune responses in the respiratory tissue. Through intranasal delivery, it elicits robust mucosal immune responses and full protection without any adjuvants. Therefore, this intranasal mosaic NP vaccine can be further developed as a pan‐sarbecovirus vaccine to block the viral entrance from the upper respiratory tract.
High‐Density Nanopore Confined Vortical Dipoles and Magnetic Domains on Hierarchical Macro/Meso/Micro/Nano Porous Ultra‐Light Graphited Carbon for Adsorbing Electromagnetic Wave
Authors: Huang Wenhuan , Zhang Xingxing , Chen Jiamin , Qiu Qiang , Kang Yifan , Pei Ke , Zuo Shouwei , Zhang Jincang , Che Renchao 
Published: August 2023

AbstractAtomic‐level structural editing is a promising way for facile synthesis and accurately constructing dielectric/magnetic synergistic attenuated hetero‐units in electromagnetic wave absorbers (EWAs), but it is hard to realize. Herein, utilizing the rapid explosive volume expansion of the CoFe‐bimetallic energetic metallic triazole framework (CoFe@E‐MTF) during the heat treatment, the effective absorption bandwidth and the maximum absorption intensity of a series of atomic CoFe‐inserted hierarchical porous carbon (CoFe@HPC) EWAs can be modified under the diverse synthetic temperature. Under the filler loading of 15 wt%, the fully covered X and Ku bands at 3 and 2.5 mm for CoFe@HPC800 and the superb minimum reflection loss (RLmin) of −53.15 dB and specific reflection loss (SRL) of −101.24 dB mg−1 mm−1 for CoFe@HPC1000 are achieved. More importantly, the single‐atomic chemical bonding among Co─Fe on the nanopores is captured by extended X‐ray absorption fine structure, which reveals the formation mechanism of nanopore‐confined vortical dipoles and magnetic domains. This work heralds the infinite possibilities of atomic editing EWA in the future.
An effective strategy to boost hydrogen separation performance through stable mixed proton‐electron conducting membrane
Authors: Luo Jiaming , Wang Zishuo , Li Yong , Gao Jing , Li Huimin , Norby Truls , Ku Xiaoke , Chen Xinzhi 
Published: August 2023

AbstractHydrogen separation and purification are key to widespread application of hydrogen energy. Hydrogen permeable membranes based on lanthanum tungstate (LWO) attract attention due to favorable mechanical strength and chemical stability. However, industrial application of LWO‐based membranes has remained challenging because of modest hydrogen permeances. Here we report a novel graded porous supported symmetric (GPSS) LWO‐based membrane with improved transport properties, gas exchange dynamics, and operational stability, boosting stable hydrogen flux by several times over previously reported state‐of‐the‐art membranes.
Spontaneous splenic rupture due to occult signet‐ring cell gastric cancer accompanied by a bulky splenic vein thrombosis and postoperative brain infarction: A case report
Authors: Asada Shimpei , Mori Shusuke , Takemoto Akira , Tamura Kazuhiro , Ito Go , Otomo Yasuhiro 
Published: August 2023

AbstractBackgroundSplenic rupture because of metastasis from a distant organ is extremely rare.Case PresentationAn 80‐year‐old man presented with left flank pain. A computed tomography (CT) demonstrated a poorly enhanced enlarged spleen with bulky thrombus in the splenic vein without extravasations. A CT on the following day showed increased intraperitoneal hemorrhage; therefore, an emergency laparotomy was performed. The spleen was enlarged and ruptured with lacerations on its surface. Macroscopic examination showed congestion with a thrombus in the splenic vein around the hilum. Pathology revealed signet‐ring cell carcinoma. On the third postoperative day, a massive cerebral infarction in the left middle cerebral artery was revealed. Endoscopic examination demonstrated normal gastric mucosa except for some erosions, for which biopsies were performed, and two of five specimens encompassed signet‐ring cell carcinoma in the lamina propria.ConclusionOccult cancer could result in a drastic manifestation of its metastasis accompanying systemic thrombotic events.
Research progress and applications of genome‐wide association study in farm animals
Authors: Tan Xiaodong , He Zhengxiao , Fahey Alan G. , Zhao Guiping , Liu Ranran , Wen Jie 
Published: August 2023

AbstractExploring the genetic loci underlying economic traits is foundational for innovation in modern animal breeding technology. Genome‐wide association studies (GWAS) have been valid and commonly used tools to dissect the genomic variants associated with phenotypes for the past ∼20 years and have contributed to our understanding of genetic and molecular bases of various traits. Here, we comprehensively review the recent research progress on GWAS methods. We highlight the methodological advancements enabled by the combination of new proteome, transcriptome, epigenome, and metagenome information and multi‐omics analysis algorithms. The advances in GWAS investigations of chickens, pigs, cattle, and other animals during the last 5 years are also described. Finally, we discuss the current applications of GWAS in cutting‐edge breeding technologies and overall future perspectives of the post‐GWAS era.
Associations between prediagnostic aspirin use and ovarian tumor gene expression
Authors: Sasamoto Naoko , Stewart Paul A. , Wang Tianyi , Thompson Zachary J. , Yoder Sean J. , Hecht Jonathan L. , Cleveland John L. , Conejo‐Garcia Jose , Fridley Brooke L. , Terry Kathryn L. , Tworoger Shelley S. 
Published: August 2023

AbstractBackgroundAspirin use has been associated with reduced ovarian cancer risk, yet the underlying biological mechanisms are not fully understood. To gain mechanistic insights, we assessed the association between prediagnosis low and regular‐dose aspirin use and gene expression profiles in ovarian tumors.MethodsRNA sequencing was performed on high‐grade serous, poorly differentiated, and high‐grade endometrioid ovarian cancer tumors from the Nurses' Health Study (NHS), NHSII, and New England Case–Control Study (n = 92 cases for low, 153 cases for regular‐dose aspirin). Linear regression identified differentially expressed genes associated with aspirin use, adjusted for birth decade and cohort. False discovery rates (FDR) were used to account for multiple testing and gene set enrichment analysis was used to identify biological pathways.ResultsNo individual genes were significantly differentially expressed in ovarian tumors in low or regular‐dose aspirin users accounting for multiple comparisons. However, current versus never use of low‐dose aspirin was associated with upregulation of immune pathways (e.g., allograft rejection, FDR = 5.8 × 10−10; interferon‐gamma response, FDR = 2.0 × 10−4) and downregulation of estrogen response pathways (e.g., estrogen response late, FDR = 4.9 × 10−8). Ovarian tumors from current regular aspirin users versus never users were also associated with upregulation in interferon pathways (FDR <1.5 × 10−4) and downregulation of multiple extracellular matrix (ECM) architecture pathways (e.g., ECM organization, 4.7 × 10−8).ConclusionOur results suggest low and regular‐dose aspirin may impair ovarian tumorigenesis in part via enhancing adaptive immune response and decreasing metastatic potential supporting the likely differential effects on ovarian carcinogenesis and progression by dose of aspirin.
3D Self‐Supported Catalyst with Multiple Active Components for Efficient Neutral Hydrogen Evolution Reaction
Authors: Guan Yonghui , Dong Lin , Qiu Luchun , Yan Ping , Yu Xin‐Yao 
Published: August 2023

AbstractUp to now, the hydrogen evolution reaction (HER) are mainly investigated in strong acidic/alkaline electrolytes. However, the HER in extreme conditions shows several drawbacks, including the corrosion of electrolyzer, water pollution, and the use of expensive anion/cation exchange membranes. The HER in neutral media is desirable to address these issues. Nevertheless, the neutral HER still faces a great challenge due to its slow kinetics. Herein, we report a plasma‐assisted approach to synthesize an efficient electrocatalyst (denoted as 3D P−Mo−NiFe LDH) with multiple active components (Ni nanoparticles, Ni3Mo alloy nanoparticles, oxygen vacancies, and molybdate‐incorporated NiFe layered double hydroxide nanosheets) supported on Cu2+1O nanorod array for neutral HER. The 3D hierarchical nanostructure can endow the catalyst with enhanced mass transfer and more exposed active sites, while the multiple active components can accelerate the HER kinetics in neutral media. As expected, the 3D P−Mo−NiFe LDH exhibits outstanding HER activity (24 mV@10 mA cm−2) and excellent stability (up to 200 h) in 1 M phosphate buffer solution (PBS).
Hydrogen Fuel Cell Technology Revolution and Intervention Using TRIZ S‐curve Analysis for Automotive System Innovation
Authors: Abdul Rahim Zulhasni , Iqbal Muhammad Saqib 
Published: August 2023

AbstractThe global energy industrial sector is focused on and committed to supporting clean energy usage and reducing or eliminating the emission of greenhouse gases by 2050. The most preferred technological energy source is the hydrogen‐based energy source of the future. This study investigates challenges in the context of technical and non‐technical perspectives using one of the tools under the theory of inventive problem solving (TRIZ). The TRIZ tool called S‐curve analysis helps assess the technological maturity of the hydrogen fuel cell at four stages: infant, growth, mature and decline, using specific indicators developed by the founder of TRIZ, Genrich Altshuller. The application of TRIZ expands the intervention strategies to successfully accelerate the development of hydrogen fuel cell technology towards the growth stage. Here, an S‐curve analysis application will be applied on the hydrogen fuel cell technologies patented in the selected country as a case study in automotive system innovation. The data of patent mapping can support the recommendations presented by TRIZ S‐curve analysis, and a proposal of intervention has been delivered to improve the growth of targeted country energy sectors through the strategic initiative of automotive technology evolution and revolution of the hydrogen fuel cell.