bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beating the Odds: Women’s Leadership in International Organizations
Authors: Sokolova Maria V. , DiCaprio Alisa , Bivens Collinson Nicole , Quirante Zyra 
Published: April 2023

AbstractDespite gains at lower levels, women have made limited inroads into leadership roles in international organizations. Using a novel data set of both nominees and selected heads of 129 international organizations, we uncover several empirical patterns. Women’s representation at the highest levels remains far below parity but has been improving steadily since the 1990s. One caveat is that this improvement has only occurred in a subset of institutions, which suggests a concentration of women leaders. Based on the available data, we examine whether the appointment of a woman leader impacts equality in the institution’s overall staffing profile. We find that such changes occur only once there is a history of appointing women. We also look at the nominations process and find that when women are included in the nominee pool, they tend to be selected, although often they are absent. Our analysis contributes much-needed data to the broader literature on leadership in international organizations and introduces a new data set with a range of other potential applications.
Effect of COVID-19 pandemic on utilisation of community-based mental health care in North-East of Italy: A psychiatric case register study
Authors: Prina E. , Tedeschi F. , Salazzari D. , Botte T. , Ballarin M. , Rabbi L. , Imperadore G. , Roccato S. , Nicolaou S. , Ruggeri M. , Gomez F. , Lasalvia A. , Amaddeo F. 
Published: April 2023

Abstract

Aims
WHO declared that mental health care should be considered one essential health service to be maintained during the coronavirus disease 2019 (COVID-19) pandemic. This study aims to describe the effect of lockdown and restrictions due to the COVID-19 pandemic in Italy on mental health services’ utilisation, by considering psychiatric diagnoses and type of mental health contacts.

Methods
The study was conducted in the Verona catchment area, located in the Veneto region (northeastern Italy). For each patient, mental health contacts were grouped into: (1) outpatient care, (2) social and supportive interventions, (3) rehabilitation interventions, (4) multi-professional assessments, (5) day care. A ‘difference in differences’ approach was used: difference in the number of contacts between 2019 and 2020 on the weeks of lockdown and intermediate restrictions was compared with the same difference in weeks of no or reduced restrictions, and such difference was interpreted as the effect of restrictions. Both a global regression on all contacts and separate regressions for each type of service were performed and Incidence Rate Ratios (IRRs) were calculated.

Results
In 2020, a significant reduction in the number of patients who had mental health contacts was found, both overall and for most of the patients’ characteristics considered (except for people aged 18–24 years for foreign-born population and for those with a diagnosis of schizophrenia. Moreover, in 2020 mental health contacts had a reduction of 57 096 (−33.9%) with respect to 2019; such difference remained significant across the various type of contacts considered, with rehabilitation interventions and day care showing the greatest reduction. Negative Binomial regressions displayed a statistically significant effect of lockdown, but not of intermediate restrictions, in terms of reduction in the number of contacts. The lockdown period was responsible of a 32.7% reduction (IRR 0.673; p-value <0.001) in the overall number of contacts. All type of mental health contacts showed a reduction ascribable to the lockdown, except social and supportive interventions.

Conclusions
Despite the access to community mental health care during the pandemic was overall reduced, the mental health system in the Verona catchment area was able to maintain support for more vulnerable and severely ill patients, by providing continuity of care and day-by-day support through social and supportive interventions.
Multi-Site Replications in Social Psychology: Reflections, Implications, and Future Directions
Authors: Baumeister Roy F. , Bushman Brad J. , Tice Dianne M. 
Published: April 2023

Abstract
Social psychology findings have fared poorly in multi-site replication attempts. This article considers and evaluates multiple factors that may contribute to such failures, other than the “crisis” assumption that most of the field’s published research is so badly flawed that it should be dismissed wholesale. Low engagement by participants may reduce replicability of some findings (while not affecting certain others). Incentives differ between original researchers and replicators. If multi-site replications are indeed biased toward failure, this may have a damaging effect on the field’s ability to build correct theories.
Coherent Mechanistic Patterns of Tropical Land Hydroclimate Changes
Authors: Duan Suqin Q. , Findell Kirsten L. , Fueglistaler Stephan A. 
Published: April 2023

AbstractChanges in tropical (30 S–30 N) land hydroclimate following CO2‐induced global warming are organized according to climatological aridity index (AI) and daily soil moisture (SM) percentiles. The transform from geographical space to this novel process‐oriented phase space allows for interpretation of local, daily mechanistic relationships between key hydroclimatic variables in the context of time‐mean and/or global‐mean energetic constraints and the wet‐get‐wetter/dry‐get‐drier paradigm. Results from 16 CMIP models show coherent patterns of change in the AI/SM phase space that are aligned with the established soil‐moisture/evapotranspiration regimes. We introduce an active‐rain regime as a special case of the energy‐limited regime. Rainfall shifts toward larger rain totals in this active‐rain regime, with less rain on other days, resulting in an overall SM reduction. Consequently, the regimes where SM constrains evapotranspiration become more frequently occupied, and corresponding hydroclimatic changes align with the position of the critical SM value in the AI/SM phase space.
Dipolarization Events With Inductive, Radial Electric Fields Observed by Van Allen Probes
Authors: Matsui H. , Torbert R. B. , Spence H. E. , Cooper M. B. , Farrugia C. J. , Gkioulidou M. , Metivier T. J. , Wygant J. R. 
Published: April 2023

AbstractDipolarization events with inductive, radial electric fields are examined, using Van Allen Probes data between 2012 and 2019. Two cases are studied, followed by statistical analyses. These events were observed between evening and premidnight magnetic local times (MLTs) under moderate geomagnetic activities. Radial electric field variations, azimuthal magnetic field variations, and energetic protons were often observed when horizontal magnetic fields started to decrease in the dip region. Magnetic field lines were stretched with their motion similar to the gradient B/curvature drift velocities of energetic protons. Signs of electric fields changed when horizontal magnetic fields started to increase in the dipolarization front (DF). Electric field and magnetic field variations were correlated and in quadrature regarding the phase relation. Among other explanations, we interpret these observations in terms of energetic proton structures drifting toward the probe locations, while being accompanied by standing waves.
Upward Leaders Initiated From Instrumented Lightning Rods During the Approach of a Downward Leader in a Cloud‐To‐Ground Flash
Authors: Saba Marcelo M. F. , Lauria Paola B. , Schumann Carina , Silva José Claudio de O. , Mantovani Felipe de L. 
Published: April 2023

AbstractIn this paper we analyze electric‐field and current measurements of upward leaders induced by a downward negative lightning flash that struck a residential building. The attachment process was recorded by two high‐speed cameras running at 37,800 and 70,000 images per second and the current measured in two lightning rods. Differently from previous works, here we show, for the first time, current measurements of multiple upward leaders that after initiation propagate to connect the negative downward moving leader. At the beginning of the propagation of the leaders that initiate on the instrumented lightning rods, current pulses appear superimposed to a steadily increasing DC current. The upward leader current pulses increase with the approach of the downward leader and are not synchronized but present an alternating pattern. All 2D leader speeds are approximately constant. The upward leaders are slower than the downward leader speed. The average time interval between current pulses in upward leaders is close to the interstep time interval found by optical or electric field sensors for negative cloud‐to‐ground stepped leaders. The upward leaders respond to different downward propagating branches and, as the branches alternate in propagation and intensity, so do the leaders accordingly. Right before the attachment process the alternating pattern of the leaders ceases, all downward leader branches intensify, and consequently upward leaders synchronize and pulse together. The average linear densities for upward leaders (49 and 82 μC/m) were obtained for the first time for natural lightning.
Estimating Global GPP From the Plant Functional Type Perspective Using a Machine Learning Approach
Authors: Guo Renjie , Chen Tiexi , Chen Xin , Yuan Wenping , Liu Shuci , He Bin , Li Lin , Wang Shengzhen , Hu Ting , Yan Qingyun , Wei Xueqiong , Dai Jie 
Published: April 2023

AbstractThe long‐term monitoring of gross primary production (GPP) is crucial to the assessment of the carbon cycle of terrestrial ecosystems. In this study, a well‐known machine learning model (random forest, RF) is established to reconstruct the global GPP data set named ECGC_GPP. The model distinguished nine functional plant types, including C3 and C4 crops, using eddy fluxes, meteorological variables, and leaf area index (LAI) as training data of RF model. Based on ERA5_Land and the corrected GEOV2 data, global monthly GPP data set at a 0.05° resolution from 1999 to 2019 was estimated. The results showed that the RF model could explain 74.81% of the monthly variation of GPP in the testing data set, of which the average contribution of LAI reached 41.73%. The average annual and standard deviation of GPP during 1999–2019 were 117.14 ± 1.51 Pg C yr−1, with an upward trend of 0.21 Pg C yr−2 (p < 0.01). By using the plant functional type classification, the underestimation of cropland is improved. Therefore, ECGC_GPP provides reasonable global spatial pattern and long‐term trend of annual GPP.
Impact of Parameterized Isopycnal Diffusivity on Shelf‐Ocean Exchanges Under Upwelling‐Favorable Winds: Offline Tracer Simulations Augmented by Artificial Neural Network
Authors: Xie Chenyue , Wei Huaiyu , Wang Yan 
Published: April 2023

AbstractIsopycnal eddy mixing across continental slopes profoundly modulates the ocean circulation and biogeochemistry. Yet this process must be parameterized in coarse‐resolution ocean models via an isopycnal eddy diffusivity prescribed with the Redi scheme. In this work, we evaluate the skill of physics‐based and data‐driven Redi variants in predicting the cross‐slope exchanges using a suite of offline‐mode parameterized tracer simulations for wind‐driven upwelling continental slope fronts, which commonly arise around the margins of subtropical gyres. The tested physics‐based Redi variants range from a constant eddy diffusivity to a recently proposed, bathymetry‐aware diffusivity augmented by the artificial neural network (ANN) that infers the mesoscale eddy kinetic energy from the mean flow and topographic quantities. Moreover, a purely data‐driven eddy diffusivity is learned by the ANN from the output data set of an eddy‐resolving model, whose solutions serve as the ground truth against which the parameterized tracer simulations are compared. Among all tested Redi variants, the ANN‐learned diffusivity and the bathymetry‐aware diffusivity outperform others in reproducing the tracer solutions of the eddy‐resolving model. However, a physics‐based Redi variant with local deficiencies can introduce global errors in the predicted tracer distribution, which calls for ongoing efforts in constraining the shelf‐to‐ocean transition of the isopycnal eddy diffusivity. A purely data‐driven diffusivity can nearly reproduce the diagnosed diffusivity from the eddy‐resolving model, which highlights the efficacy of machine learning techniques for parameterizing eddy processes across steep topography. This work serves as a key step toward parameterizing the isopycnal eddy mixing in ocean models with continental slopes.
A Simple Multiscale Intermediate Coupled Stochastic Model for El Niño Diversity and Complexity
Authors: Chen Nan , Fang Xianghui 
Published: April 2023

AbstractEl Niño‐Southern Oscillation (ENSO) is the most prominent interannual climate variability in the tropics and exhibits diverse features in spatiotemporal patterns. This paper develops a simple multiscale intermediate coupled stochastic model to capture the ENSO diversity and complexity. The model starts with a deterministic and linear coupled interannual atmosphere, ocean, and sea surface temperature (SST) system. It can generate two dominant linear solutions representing the eastern Pacific (EP) and the central Pacific (CP) El Niños, respectively. In addition to adopting a stochastic model for characterizing the intraseasonal wind bursts, another simple stochastic process is developed to describe the decadal variation of the background Walker circulation. The latter links the two dominant modes in a simple nonlinear fashion and advances the modulation of the strength and occurrence frequency of the EP and the CP events. Finally, cubic nonlinear damping is adopted to parameterize the relationship between subsurface temperatures and thermocline depth. The model succeeds in reproducing the spatiotemporal dynamical evolution of different types of ENSO events. It also accurately recovers the strongly non‐Gaussian probability density function, the seasonal phase locking, the power spectrum, and the temporal autocorrelation function of the SST anomalies in all the three Niño regions (3, 3.4, and 4) across the equatorial Pacific. Furthermore, both the composites of the SST anomalies for various ENSO events and the strength‐location bivariate distribution of equatorial Pacific SST maxima for the El Niño events from the model simulation highly resemble those from the observations.
The Zonal Patterns in Late Quaternary Tropical South American Precipitation
Authors: Kukla T. , Winnick M. J. , Laguë M. M. , Xia Z. 
Published: April 2023

AbstractSpeleothem oxygen isotope records (δ18O) of tropical South American rainfall in the late Quaternary show a zonal “South American Precipitation Dipole” (SAPD). The dipole is characterized by opposing east‐west precipitation anomalies compared to the present—wetter in the east and drier in the west at the mid‐Holocene (∼7 ka), and drier in the east and wetter in the west at the Last Glacial Maximum (∼21 ka). However, the SAPD remains enigmatic because it is expressed differently in western versus eastern δ18O records and isotope‐enabled climate model simulations usually misrepresent the magnitude and/or spatial pattern of δ18O change. Here, we address the SAPD enigma in two parts. First, we re‐interpret the δ18O data to account for upwind rainout effects that are known to be pervasive in tropical South America, but are not always considered in Quaternary paleoclimate studies. Our revised interpretation reconciles the δ18O data with cave infiltration and other proxy records, and indicates that the centroid of tropical South American rainfall has migrated zonally over time. Second, using an energy balance model of tropical atmospheric circulation, we hypothesize that zonal migration of the precipitation centroid can be explained by regional energy budget shifts, such as changing Saharan albedo associated with the African Humid Period, that have not been modeled in previous SAPD studies. This hypothesis of a migrating precipitation centroid presents a new framework for interpreting δ18O records from tropical South America and may help explain the zonal rainfall anomalies that predate the late Quaternary.
On Sparsity Related to the Integral Equations of 2D Electromagnetic Scattering
Authors: Sandström Sven‐Erik 
Published: April 2023

AbstractThe integral equations of electromagnetic scattering are often solved with the Fast Multipole Method. If the application involves multiple excitations one could instead consider methods that separate factorization and solution. The cost of an elaborate factorization could then be compensated for by an efficient solution. An approach to obtain substantial sparsity in the solution step is considered here. By using the generality provided by the integral representation, the kernel is modified so as to create sparsity in the resulting linear system. In the two modifications that are described here there is an attempt to optimize the shape of the kernel with respect to sparsity and accuracy.
Dating Strike‐Slip Ductile Shear Through Combined Zircon‐, Titanite‐ and Apatite U–Pb Geochronology Along the Southern Tan‐Lu Fault Zone, East China
Authors: Qiu Erkang , Zhang Yueqiao , Larson Kyle P. , Li Bingxi 
Published: April 2023

AbstractDating the timing of ductile shear deformation is critical to the understanding of complex, multi‐episode kinematics that commonly occur within the study of continental tectonics. The Tan‐Lu fault zone (TLFZ) in East China is a lithospheric discontinuity that records multistage sinistral strike‐slip shearing during Mesozoic time. Herein, based on field mapping, pressure‐temperature estimates via microstructures, quartz lattice preferred orientations, and geothermobarometer analysis, and U–Pb geochronology, we present a detailed examination of a portion of the southern TLFZ known as the Fucha Shan ductile shear zone. Two phases of sinistral ductile shear deformation in the shear zone are identified. The main phase occurred under amphibolite‐facies metamorphic conditions (500°C–650°C, 2.8–5.2 Kbar). U–Pb dating of synkinematic titanite indicate deformation occurred ca. 142–140 Ma. This age information is consistent with U–Pb dating of zircon from crosscutting granitic dikes that provide an upper limit of the shearing of ca. 134 Ma. A later, but less well‐developed phase of sinistral ductile shearing variably overprints older structures within the Fucha Shan shear zone at greenschist‐facies metamorphic conditions. U–Pb dating of apatite grains in rocks that record this later event are interpreted to indicate that shearing occurred ca. 118–108 Ma. These results provide new insight into Early Cretaceous shear deformation history within the southern TLFZ in the context of the late Mesozoic intracontinental deformation in East Asia.
Oncolytic virotherapy: basic principles, recent advances and future directions
Authors: Lin Danni , Shen Yinan , Liang Tingbo 
Published: April 2023

AbstractOncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they are generally considered to have direct oncolysis and cancer immune effects. With the progress in genetic engineering technology, OVs have been adopted as versatile platforms for developing novel antitumor strategies, used alone or in combination with other therapies. Recent studies have yielded eye-catching results that delineate the promising clinical outcomes that OVs would bring about in the future. In this review, we summarized the basic principles of OVs in terms of their classifications, as well as the recent advances in OV-modification strategies based on their characteristics, biofunctions, and cancer hallmarks. Candidate OVs are expected to be designed as “qualified soldiers” first by improving target fidelity and safety, and then equipped with “cold weapons” for a proper cytocidal effect, “hot weapons” capable of activating cancer immunotherapy, or “auxiliary weapons” by harnessing tactics such as anti-angiogenesis, reversed metabolic reprogramming and decomposing extracellular matrix around tumors. Combinations with other cancer therapeutic agents have also been elaborated to show encouraging antitumor effects. Robust results from clinical trials using OV as a treatment congruously suggested its significance in future application directions and challenges in developing OVs as novel weapons for tactical decisions in cancer treatment.
Remineralization of teeth with casein phosphopeptide-amorphous calcium phosphate: analysis of salivary pH and the rate of salivary flow
Authors: Alkarad Lubna , Alkhouli Muaaz , Dashash Mayssoon 
Published: April 2023

Abstract
Aim
To investigate the changes of salivary flow rate and salivary pH of Syrian children with mixed dentition following application of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP).

Methods
This study is part of a double-blind randomized controlled clinical trial. It included 50 children aged 6–8 who were randomly divided into two treatment groups to receive either CPP-ACP GC Tooth Mousse™ (Group A) or placebo (Group B) with 25 participants per group. After the application of the product in the mouth for 3 min, saliva samples were collected four times (T0, T1, T2, and T3) to measure salivary pH and the rate of salivary flow.

Results
There was no significant difference between group A and B in the mean value of salivary flow rate (t = 1.08, P = 0.28, 0.57 ± 0.28 versus 0.56 ± 0.38 respectively) and salivary pH (t = 0.61, P = 0.54, 7.28 ± 0.44 versus 7.25 ± 0.36 respectively). However, there was a significant difference between different time points (T0, T1, T2, and T3) in the mean value of salivary flow rate (0.41 ± 0.30, 0.65 ± 0.36, 0.53 ± 0.28, and 0.56 ± 0.34 respectively) and salivary pH (6.99 ± 0.44, 7.46 ± 0.36, 7.36 ± 0.32, and 7.26 ± 0.32 respectively).

Conclusion
The application of the GC Tooth Mouse (CPP-ACP) was similar to placebo in increasing the salivary pH and salivary flow rate.

Trial registration
ISRCTN17509082, Registration date 22/11/2022.
TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms
Authors: Shah Mithun Vinod , Tran Elizabeth Ngoc Hoa , Shah Syed , Chhetri Rakchha , Baranwal Anmol , Ladon Dariusz , Shultz Carl , Al-Kali Aref , Brown Anna L. , Chen Dong , Scott Hamish S. , Greipp Patricia , Thomas Daniel , Alkhateeb Hassan B. , Singhal Deepak , Gangat Naseema , Kumar Sharad , Patnaik Mrinal M. , Hahn Christopher N. , Kok Chung Hoow , Tefferi Ayalew , Hiwase Devendra K. 
Published: April 2023

AbstractRevised diagnostic criteria for myeloid neoplasms (MN) issued by the International Consensus Classification (ICC) and the World Health Organization (WHO) recommended major change pertaining to TP53-mutated (TP53mut) MN. However, these assertions have not been specifically examined in therapy-related myeloid neoplasm (t-MN), a subset enriched with TP53mut. We analyzed 488 t-MN patients for TP53mut. At least one TP53mut with variant allele frequency (VAF) ≥ 2% with or without loss of TP53 locus was noted in 182 (37.3%) patients and 88.2% of TP53mut t-MN had a VAF ≥10%. TP53mut t-MN with VAF ≥ 10% had a distinct clinical and biological profile compared to both TP53mut VAF < 10% and wild-type TP53 (TP53wt) cases. Notably, TP53mut VAF ≥ 10% had a significantly shorter survival compared to TP53wt (8.3 vs. 21.6 months; P < 0.001), while the survival of TP53mut VAF < 10% was comparable to TP53wt. Within TP53mut VAF ≥ 10% cohort, the inferior outcomes persisted irrespective of the single- or multi-hit status, co-mutation pattern, or treatments received. Finally, survival of TP53mut patients was poor across all the blast categories and MDS patients with >10% blasts had inferior survival compared to <5%. In summary, TP53mut VAF ≥10% signified a clinically and molecularly homogenous cohort regardless of the allelic status.