bluuebunny/crossref_metadata_2025_split huggingface dataset:
A two-field dark energy model with cubic contractions of the Riemann tensor
Authors: Marciu Mihai 
Published: April 2023

The paper proposes a novel cosmological model based on a two-field scenario, where the two fields are independently coupled with a specific invariant, based on cubic contractions of the Riemann tensor. After obtaining the modified Friedmann equations and the specific Klein–Gordon relations, the investigation studies the corresponding physical features by adopting the linear stability theory in a quintom scenario case where the coupling functions and potential energies have an exponential behavior. The corresponding investigation revealed a high complexity of the phase space structure, with various stationary points which can explain different aspects in the evolution of our Universe, the matter dominated epoch, and the late time accelerated stage. The present model can represent a viable solution to the dark energy problem due to the high complexity of the phase space and the existence of the scaling solutions.
Absorption, scattering and shadow by a noncommutative black hole with global monopole
Authors: Anacleto M. A. , Brito F. A. , Campos J. A. V. , Passos E. 
Published: April 2023

AbstractIn this paper, we investigate the process of massless scalar wave scattering due to a noncommutative black hole with a global monopole through the partial wave method. We computed the cross section of differential scattering and absorption at the low frequency limit. We also calculated, at the high frequency limit, the absorption and the shadow radius by the null geodesic method. We showed that noncommutativity causes a reduction in the differential scattering/absorption cross section and shadow radius, while the presence of the global monopole has the effect of increasing the value of such quantities. In the limit of the null mass parameter, we verify that the cross section of differential scattering, absorption and shadow ray approach to a non-zero value proportional to a minimum mass.
Prediction of Vortex-Induced Vibration Response of Open Bridge Girder Based on Machine Learning Method
Authors: Ma Zhen-Xing , Li Jia-Wu , Wang Feng , Cheng Ling-Xiang , Zhao Guo-Hui , Qiao Xiao-Ru 
Published: April 2023

The [Formula: see text]-shaped open section girder is a very common section, which has been widely used in the construction of modern bridges. However, compared with a streamlined box girder, it is easy to cause vortex-induced vibration (VIV) in bridges due to its bluff section shape and poor aerodynamic stability. In this paper, a typical open section with a height–width ratio of 10:1 is taken as the research object. Through wind tunnel tests and numerical simulation technology, the time-history data of VIV of the [Formula: see text]-shaped section are obtained. By selecting three different neural network models to establish the relationship between external parameters (wind attack angle, wind speed, turbulence) and structural response parameters (the onset wind speed of VIV, the length of the lock-in interval). After comparing different machine learning methods, the most suitable machine learning model is selected to predict the VIV response characteristics of the main girder. The research results show that the typical open section has a serious VIV phenomenon. The BP neural network model has the best performance in predicting the VIV performance of the open section in terms of calculation speed, prediction accuracy and solving nonlinear adaptability. At the same time, it is found that different characteristic parameters of the incoming wind field have different influences on the prediction results of the VIV response. Among them, the wind attack angle is the key parameter that affects the onset wind speed of VIV, but the turbulence intensity has a greater impact on the maximum amplitude of VIV. At the same time, the optimized BP model can predict the characteristic parameters of VIV response under unknown wind fields. This paper provides a new idea to study the effect of different incoming flow parameters on the performance of section VIV and further improves people’s understanding of VIV system.
Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
Authors: Negrao Marcelo V. , Araujo Haniel A. , Lamberti Giuseppe , Cooper Alissa J. , Akhave Neal S. , Zhou Teng , Delasos Lukas , Hicks J. Kevin , Aldea Mihaela , Minuti Gabriele , Hines Jacobi , Aredo Jacqueline V. , Dennis Michael J. , Chakrabarti Turja , Scott Susan C. , Bironzo Paolo , Scheffler Matthias , Christopoulos Petros , Stenzinger Albrecht , Riess Jonathan W. , Kim So Yeon , Goldberg Sarah B. , Li Mingjia , Wang Qi , Qing Yun , Ni Ying , Do Minh Truong , Lee Richard , Ricciuti Biagio , Alessi Joao Victor , Wang Jing , Resuli Blerina , Landi Lorenza , Tseng Shu-Chi , Nishino Mizuki , Digumarthy Subba R. , Rinsurongkawong Waree , Rinsurongkawong Vadeerat , Vaporciyan Ara A. , Blumenschein George R. , Zhang Jianjun , Owen Dwight H. , Blakely Collin M. , Mountzios Giannis , Shu Catherine A. , Bestvina Christine M. , Garassino Marina Chiara , Marrone Kristen A. , Gray Jhanelle E. , Patel Sandip Pravin , Cummings Amy L. , Wakelee Heather A. , Wolf Juergen , Scagliotti Giorgio Vittorio , Cappuzzo Federico , Barlesi Fabrice , Patil Pradnya D. , Drusbosky Leylah , Gibbons Don L. , Meric-Bernstam Funda , Lee J. Jack , Heymach John V. , Hong David S. , Heist Rebecca S. , Awad Mark M. , Skoulidis Ferdinandos 
Published: April 2023

Abstract

Molecular modifiers of KRASG12C inhibitor (KRASG12Ci) efficacy in advanced KRASG12C-mutant NSCLC are poorly defined. In a large unbiased clinicogenomic analysis of 424 patients with non–small cell lung cancer (NSCLC), we identified and validated coalterations in KEAP1, SMARCA4, and CDKN2A as major independent determinants of inferior clinical outcomes with KRASG12Ci monotherapy. Collectively, comutations in these three tumor suppressor genes segregated patients into distinct prognostic subgroups and captured ∼50% of those with early disease progression (progression-free survival ≤3 months) with KRASG12Ci. Pathway-level integration of less prevalent coalterations in functionally related genes nominated PI3K/AKT/MTOR pathway and additional baseline RAS gene alterations, including amplifications, as candidate drivers of inferior outcomes with KRASG12Ci, and revealed a possible association between defective DNA damage response/repair and improved KRASG12Ci efficacy. Our findings propose a framework for patient stratification and clinical outcome prediction in KRASG12C-mutant NSCLC that can inform rational selection and appropriate tailoring of emerging combination therapies.

Significance:
In this work, we identify co-occurring genomic alterations in KEAP1, SMARCA4, and CDKN2A as independent determinants of poor clinical outcomes with KRASG12Ci monotherapy in advanced NSCLC, and we propose a framework for patient stratification and treatment personalization based on the comutational status of individual tumors.
See related commentary by Heng et al., p. 1513.
This article is highlighted in the In This Issue feature, p. 1501
La garnatilla (Granada, Espanha). Memórias e tristezas dos que partiram rumo a américa do sul. Um estudo sobre o bairro do Brás em São Paulo
Authors: Monteiro Arlete Assumpção 
Published: April 2023

O presente artigo integra uma pesquisa mais ampla sobre a importância da imigração espanhola para o desenvolvimento industrial de São Paulo. Estudo realizado na região de origem dos que partiram em busca de melhores condições de vida, a Comunidade Autônoma de Andalucia, composta pelas províncias de Almeria, Granada, Málaga, Jaén, Córdova, Cádiz, Huelva e Sevilha, a capital. A pesquisa foi realizada sob a orientação do historiador Prof. Dr. Juan Marchena Fernandez, catedrático da Universidad Pablo de Olavide, localizada em Sevilha, que sugeriu que fosse realizado um trabalho de campo na cidade mediterrânea de Motril, província de Granada, onde a população vivia da agricultura, principalmente tratando dos vinhedos para produção do vinagre, da agricultura da cana-de-açúcar e do trabalho nos engenhos para produção do açúcar. Com a crise econômica que a região vivenciou no final do século XIX e princípio do XX, motivada pela praga nos vinhedos, a filoxera, e pela decadência da produção do açúcar nos engenhos, além da preocupação das famílias em evitar que os jovens em idade do serviço militar fossem para as guerras nas colônias espanholas, a saída foi emigrar, sendo uma das alternativas a América do Sul, principalmente para São Paulo, Brasil e para o Chaco Argentino. Tal estudo teve a preocupação de se entender melhor o Bairro do Brás (e arredores), importante “locus” de fixação dos imigrantes espanhóis em São Paulo.
Characterization of Aortic Flow Patterns by High‐Frame‐Rate Blood Speckle Tracking Echocardiography in Children
Authors: Cantinotti Massimiliano , Marchese Pietro , Scalese Marco , Giordano Raffaele , Franchi Eliana , Assanta Nadia , Koestenberger Martin , Barnes Benjamin T. , Celi Simona , Jani Vivek , Voges Inga , Kutty Shelby 
Published: April 2023

Background
Blood speckle tracking echocardiography allows for direct quantification of interventricular and aortic flow profiles, principally in children. Here, we sought to demonstrate the feasibility and reproducibility of blood speckle tracking echocardiography in the aortas of healthy children.

Methods and Results

One hundred healthy White children evaluated for the screening of congenital heart disease were prospectively enrolled. Echocardiographic examinations were performed using a Vivid E 95 ultrasound system, with blood speckle tracking from a focused and zoomed view of the aortic root and the ascending aorta. Vortex position, height (mm), width (mm), sphericity index, and area (cm
2
) were measured and indexed by body surface area. Median (interquartile range) age was 8.2 (5.6–11.0) years, median (interquartile range) weight was 28 (19–35) kg, and median (interquartile range) body surface area was 1.01 (0.79–1.16) m
2
. Vortices were visualized in only a single phase of the cardiac cycle in 25 subjects—14 (56.0%) were evident in early diastole and 11 (44.0%) in late systole. Vortices visualized in diastole had a mean area of 0.27±0.1 cm
2
/m
2
, while those in systole had a mean area of 0.34±0.12 cm
2
/m
2
. In a subset of 20 patients, inter‐ and intraobserver coefficient of variation and intraclass correlation coefficients were determined and showed good reproducibility.

Conclusions
We demonstrate feasibility and reproducibility of blood speckle tracking and identified vortical flow patterns in the aortic root and ascending aorta in healthy children. These data may serve as a baseline for evaluating aortic flow patterns in children with congenital and acquired heart disease.
What Are the Balanced and Unbalanced Dynamics of a Tropical Cyclone?
Authors: Ji Dong , Qiao Fangli 
Published: April 2023

Abstract
Recently, Ji and Qiao took into account the unbalanced components and derived an extended Sawyer–Eliassen (SE) equation. This study developed a new derivation of this extended SE equation from the perspective of restoring forces, and gives a physical interpretation for the coefficients that appear in the SE equation. For an unbalanced vortex, we demonstrated that the thermodynamic fields are only determined by the distribution of gradient wind, and thus, the gradient wind and thermodynamic fields always remain in balance as the unbalanced vortex evolves. Consequently, we attributed the gradient wind imbalance to the agradient wind rather than to the thermodynamic fields. Subsequently, we explored the effect of the agradient wind on the secondary circulation, and showed that the agradient wind strengthens the secondary circulation in its vicinity, which can be explained as a consequence of the restoring forces and mass continuity. Furthermore, we speculated that the SE equation, together with the radial velocity equation, could reproduce the primary characteristic of the axisymmetric boundary layer dynamics by prescribing the parameterization of subgrid-scale turbulent mixing. Specifically, the noU_BL and noVa_BL experiments conducted by Fei et al. in an article published in 2021 were reinterpreted, and the oscillation wavelength of the agradient wind in the eyewall was approximated based on this framework. Additionally, a new numerical solution algorithm to overcome the hyperbolicity near the boundary layer was proposed. This study attempts to develop a complete dynamic theory for tropical cyclones in both qualitative and quantitative perspectives.
Near-Surface Wind Convergence over the Gulf Stream—The Role of SST Revisited
Authors: Small R. J. , Rousseau V. , Parfitt R. , Laurindo L. , O’Neill L. , Masunaga R. , Schneider N. , Chang P. 
Published: April 2023

Abstract
High-resolution observations have demonstrated the presence of strong time-mean near-surface wind convergence (NSWC) anchored across oceanic frontal zones, such as the western boundary currents. Initial analyses appeared to show a close association between this time-mean NSWC and time-mean properties of the underlying sea surface temperature (SST), such as the gradients and second derivatives (e.g., Laplacian of SST), acting through pressure-adjustment and vertical-mixing mechanisms. However, a series of recent papers have revealed the instantaneous NSWC to be dominated by atmospheric fronts and have suggested the importance of air–sea processes occurring instead on shorter, synoptic time scales. In this paper, using the ERA5 reanalysis dataset in the Gulf Stream region, we aim to reconcile these viewpoints by investigating the spatial and temporal dependence of NSWC and its relationship to SST. It is revealed that while atmospheric frontal processes govern the day-to-day variability of NSWC, the relatively weak but persistent pressure-adjustment and vertical-mixing mechanisms provide lower-frequency modulations in conditions both with and without atmospheric fronts. In addition to their temporal characteristics, each mechanism is shown through spectral analysis to dominate on specific spatial scales. In light of recent work that has tied remote atmospheric responses to NSWC anomalies in western boundary current regions, these results emphasize the importance of oceanic frontal zones for atmospheric variability on all spatiotemporal scales.
Efficacy and safety of calcium polystyrene sulfonate in patients with hyperkalemia and stage 3–5 non-dialysis chronic kidney disease: a single-center randomized controlled trial
Authors: Wang Xia , Chen Dacheng , Song Xia , Wang Jinquan , Zhang Haitao 
Published: April 2023

Objective To observe the clinical efficacy and safety of the short-term administration of different doses of calcium polystyrene sulfonate in the treatment of hyperkalemia in patients with stage 3–5 non-dialysis chronic kidney disease. Methods A prospective, open, randomized, controlled, single-center clinical observation was conducted. In total, 107 patients were randomly assigned to receive calcium polystyrene sulfonate at 15 (group A) or 30 mg/day (group B) for 1 week. Patients were assessed on days 0, 3, and 7. Results After 3 days of treatment, the serum potassium levels in groups A and B had decreased by 0.68 ± 0.46 and 0.75 ± 0.43 mmol/L, respectively. After 7 days, the serum potassium levels in groups A and B had decreased by 0.64 ± 0.37 and 0.94 ± 0.49 mmol/L, respectively. Conversely, serum sodium, phosphorus, and calcium levels did not significantly change during the treatment period. Constipation was the most common adverse drug reaction, and no treatment-related serious adverse events were observed. Conclusion Calcium polystyrene sulfonate administered at a dose of 15 or 30 g/day can rapidly reduce potassium levels in patients with stage 3–5 non-dialysis chronic kidney disease without adverse effects on sodium, phosphorus, or calcium levels.
Menstrual Hygiene Practices and its Predictors Among Young Women in India: Findings from the National Family Health Survey-5 (2019–2021)
Authors: Karjee Swagata , Biswas Prites Chandra 
Published: April 2023

Introduction India is moving towards menstrual hygienic practices. However, using unhygienic menstrual absorbents is still a reproductive health concern among women in India. Objective This study investigates the prevalence of menstrual hygiene practices by geographical location and socio-economic factors among women in India. Materials and Methods National Family Health Survey-5 (NFHS-5) (2019–2021) data were utilized to fulfill the study objectives. The study participant included 241,180 young women aged 15–24 years. A bivariate chi-square test was applied to present the percentage distribution of menstrual hygienic practices. Multivariate logistic regression analyses were used to examine the predictors linked with hygienic practices related to menstruation. Results About 77% of the women used hygienic absorbents to protect menstrual bloodstains in India. The menstrual hygienic practices are significantly lower in the improvised states of central and eastern India. Multivariable analysis reveals that higher educated women (adjusted odds ratio (AOR): 5.36; 95% confidence interval (CI): 4.18–6.87) residing in the richest quintile households (AOR: 6.17; 95% CI: 4.61–8.26) have a higher probability of hygienic practices related to menstruation. Besides, higher autonomy and mass media exposure are positively associated with hygiene practices. Conclusion The study findings recommend opportunities for reproductive education among women, offering financial incentives, and improving women’s empowerment may increase menstrual hygienic practices. Additionally, interventions should focus on socioeconomically poor women to increase the use of sanitary napkin. Interventions should also focus on marginalized women to increase the use of sanitary napkin.
Young adults with depression: A registry-based longitudinal study of work-life marginalisation. The Norwegian GP-DEP study
Authors: Hetlevik Øystein , Smith-Sivertsen Tone , Haukenes Inger , Ruths Sabine , Baste Valborg 
Published: April 2023

Aims: To explore the association between a depression diagnosis in young adulthood and risk of marginalisation at age 29 years, among those who had completed upper secondary school and those who had not completed at age 21. Methods: In a longitudinal cohort study based on nationwide registers we followed 111,558 people from age 22–29 years. Outcomes were risk of marginalisation and educational achievement at age 29. Exposure was a diagnosed depression at ages 22–26 years. Comorbid mental and somatic health conditions, gender and country of origin were covariates. Relative risks were estimated with Poisson regression models, stratified by educational level at age 21. Results: For people who had not completed upper secondary school at age 21 years, a depression diagnosis at age 22–26 increased the risk of low income (relative risk = 1.33; 95% confidence interval = 1.25–1.40), prolonged unemployment benefit (1.46; 1.38–1.55) and social security benefit (1.56; 1.41–1.74) at age 29 compared with those with no depression. Among those who had completed upper secondary school at age 21 years, depression increased the risk of low income (1.71; 1.60–1.83), prolonged unemployment benefit (2.17; 2.03–2.31), social security benefit (3.62; 2.91–4.51) and disability pension (4.43; 3.26–6.01) compared with those with no depression. Mental comorbidity had a significant impact on risk of marginalisation in both groups. Conclusions: Depression in one’s mid-20s significantly increases the risk of marginalisation at age 29 years, and comorbid mental health conditions reinforce this association. Functional ability should be given priority in depression care in early adulthood to counteract marginalisation.
Programming techniques for improving rule readability for rule-based information extraction natural language processing pipelines of unstructured and semi-structured medical texts
Authors: Ladas Nektarios , Borchert Florian , Franz Stefan , Rehberg Alina , Strauch Natalia , Sommer Kim Katrin , Marschollek Michael , Gietzelt Matthias 
Published: April 2023

Background Extraction of medical terms and their corresponding values from semi-structured and unstructured texts of medical reports can be a time-consuming and error-prone process. Methods of natural language processing (NLP) can help define an extraction pipeline for accomplishing a structured format transformation strategy. Objectives In this paper, we build an NLP pipeline to extract values of the classification of malignant tumors (TNM) from unstructured and semi-structured pathology reports and import them further to a structured data source for a clinical study. Our research interest is not focused on standard performance metrics like precision, recall, and F-measure on the test and validation data. We discuss how with the help of software programming techniques the readability of rule-based (RB) information extraction (IE) pipelines can be improved, and therefore minimize the time to correct or update the rules, and efficiently import them to another programming language. Methods The extract rules were manually programmed with training data of TNM classification and tested in two separate pipelines based on design specifications from domain experts and data curators. Firstly we implemented each rule directly in one line for each extraction item. Secondly, we reprogrammed them in a readable fashion through decomposition and intention-revealing names for the variable declaration. To measure the impact of both methods we measure the time for the fine-tuning and programming of the extractions through test data of semi-structured and unstructured texts. Results We analyze the benefits of improving through readability of the writing of rules, through parallel programming with regular expressions (REGEX), and the Apache Uima Ruta language (AURL). The time for correcting the readable rules in AURL and REGEX was significantly reduced. Complicated rules in REGEX are decomposed and intention-revealing declarations were reprogrammed in AURL in 5 min. Conclusion We discuss the importance of factor readability and how can it be improved when programming RB text IE pipelines. Independent of the features of the programming language and the tools applied, a readable coding strategy can be proven beneficial for future maintenance and offer an interpretable solution for understanding the extraction and for transferring the rules to other domains and NLP pipelines.