bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a Women's Thought Collective methodology for health research: The roles and responsibilities of researchers in the reflexive co‐production of knowledge
Authors: Foley Kristen , Lunnay Belinda , Kevin Catherine , Ward Paul R. 
Published: July 2023

AbstractBackgroundCo‐produced research holds enormous value within the health sciences. Yet, there can be a heavy focus on what research participants think, do and know; while the researcher's responsibility to explore and re/work their own knowledge or praxis tends to escape from view. This is reflected in the limited use of co‐production to explore broad structural distributions of health and risk(s). We argue this missed opportunity has the potential to unfold as what Berlant calls a ‘cruel optimism’, where something desirable becomes an obstacle to flourishing and/or produces harm. We explore challenges to involving lay populations meaningfully in health research amidst a neoliberal cultural landscape that tends to responsibilise people with problems they cannot solve.Methods and FindingsDrawing together principles from hermeneutic and feminist philosophy, we develop a novel methodology for co‐producing research about determinants of health and health risk (using a case study of alcohol consumption as an example) that centres on what researchers do, know and think during research: Women's Thought Collectives.DiscussionKeeping the constructed nature of social systems—because they shape ideas of value, expertise and knowledge—in view during co‐produced research illuminates the potential for cruel optimisms within it. Such reflexive awareness carves out starting points for researchers to engage with how social hierarchies might (tacitly) operate during the co‐production of knowledge. Our work has broad utility for diverse population groups and provides important considerations around the roles and responsibilities for reflexive co‐production of knowledge at all levels of health systems.Patient or Public ContributionThe development of these ideas was sparked by working with lay participants during the Women's Thought Collectives for Kristen Foley's doctoral research 2021–2023, but undertaken without their direct involvement—in accordance with the responsibilities of researchers in the reflexive co‐production of knowledge. Forthcoming publications will address the outcomes and processes of this work.
Fusion transcriptome profiling defines the monoclonal origin of multifocal epithelioid haemangioma of bone
Authors: Errani Costantino , De Benedictis Ilaria , Righi Alberto , Valenti Beatrice , Del Savio Elisa , Baldazzi Davide , Benini Stefania , Sbaraglia Marta , Vega Jimenez Brayan , Vanel Daniel , Donati Davide Maria , Dei Tos Angelo Paolo , Maestro Roberta 
Published: July 2023

AimsEpithelioid haemangioma (EH) of bone remains a highly controversial entity. Indeed, the WHO classifies EHs of soft tissues as benign tumours, whereas bone EHs are considered intermediate–locally aggressive tumours due to common multifocal presentation and local destructive growth. To gain insights into the clinical behaviour and biology of EH of bone we retrospectively analysed 42 patients treated in a single institution from 1978 to 2021.Methods and resultsMultifocal presentation was detected in 17 of 42 patients (40%) primarily as synchronous lesions. Patients were treated with curettage (57%), resection (29%) or biopsy, followed by radiotherapy or embolisation (14%). Follow‐up (minimum 24 months) was available for 38 patients, with only five local recurrences (13%) and no death of disease. To clarify whether the synchronous bone lesions in multifocal EH represent multicentric disease or clonal dissemination, four cases were profiled by RNA‐sequencing. Separate lesions from the same patient, which showed a similar transcriptional profile, expressed the same fusion transcript (involving FOS or FOSB) with identical gene breakpoints.ConclusionsThese results indicate that, in EH of bone, multifocal lesions are clonally related and therefore represent the spread of a same neoplastic clone rather than simultaneous independent tumours. This finding is in apparent contradiction with the benign clinical course of the disease, and suggests that tumour dissemination in bone EH probably reflects a phenomenon of passive spreading, with tumour cells colonising distal sites while maintaining their benign biological nature.
Two‐tiered deep‐learning‐based model for histologic diagnosis of Helicobacter gastritis
Authors: Lin Yi‐Jyun , Chen Chi‐Chung , Lee Chia‐Hsiang , Yeh Chao‐Yuan , Jeng Yung‐Ming 
Published: July 2023

AimsHelicobacter pylori (HP) infection is the most common cause of chronic gastritis worldwide. Due to the small size of HP and limited resolution, diagnosing HP infections is more difficult when using digital slides.Methods and ResultsWe developed a two‐tier deep‐learning‐based model for diagnosing HP gastritis. A whole‐slide model was trained on 885 whole‐slide images (WSIs) with only slide‐level labels (positive or negative slides). An auxiliary model was trained on 824 areas with HP in nine positive WSIs and 446 negative WSIs for localizing HP. The whole‐slide model performed well, with an area under the receiver operating characteristic curve (AUC) of 0.9739 (95% confidence interval [CI], 0.9545–0.9932). The calculated sensitivity and specificity were 93.3% and 90.1%, respectively, whereas those of pathologists were 93.3% and 84.2%, respectively. Using the auxiliary model, the highlighted areas of the localization maps had an average precision of 0.5796.ConclusionsHP gastritis can be diagnosed on haematoxylin‐and‐eosin‐stained WSIs with human‐level accuracy using a deep‐learning‐based model trained on slide‐level labels and an auxiliary model for localizing HP and confirming the diagnosis. This two‐tiered model can shorten the diagnostic process and reduce the need for special staining.
Response to social media influencers: Consumer dispositions as drivers
Authors: Bailey Ainsworth Anthony , Mishra Aditya Shankar , Vaishnav Khushboo 
Published: July 2023

AbstractBrand managers use social media influencers (SMIs) to influence consumers' attitudes and intentions. However, there is still ambiguity about the mechanisms by which SMIs influence their followers, as well as the metrics by which their performance can be evaluated. The existing literature has restricted itself to consumers' purchase intentions in order to evaluate SMIs influence and is silent on the role of the consumers' individual characteristics in SMIs influence mechanisms. Based on these research gaps and to provide a clearer picture of the SMI influence mechanism to practitioners, the present study assesses the role of consumer characteristics such as their social media attachment (SMA), parasocial relationships with social media influencer (PSR‐SMIs), and susceptibility to SMIs influence (SSMII) in driving consumer response to SMIs influence through SMI compliance intentions. Study 1 found the sequential mediational role of PSR‐SMIs and SSMII in the SMA‐SMI compliance intentions relationship. Study 2 found the same sequential mediation and demonstrated how SMI skepticism negatively moderates the relationship between PSR‐SMIs and SMI compliance intentions. To the best of the authors' knowledge, this is the first time that this skepticism variable is being explored in the SMI literature.
Sexual function using the EORTC QLQ‐TC26 in testicular cancer survivors: A multi‐institutional, cross‐sectional study
Authors: Koyama Juntaro , Yamashita Shinichi , Kakimoto Kenichi , Uemura Motohide , Kishida Takeshi , Kawai Koji , Nakamura Terukazu , Goto Takayuki , Osawa Takahiro , Nishimura Kazuo , Nonomura Norio , Nishiyama Hiroyuki , Shiraishi Takumi , Ukimura Osamu , Ogawa Osamu , Shinohara Nobuo , Suzukamo Yoshimi , Ito Akihiro , Arai Yoichi 
Published: July 2023

ObjectiveTo evaluate sexual function after treatment using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Testicular Cancer 26 (EORTC QLQ‐TC26) questionnaire in Japanese testicular cancer (TC) survivors in a multi‐institutional, cross‐sectional study.MethodsThis study enrolled TC survivors who visited any of eight high‐volume institutions in Japan from 2018 to 2019. After obtaining informed consent, participants completed the EORTC QLQ‐TC26 questionnaires. We evaluated sexual function after treatment for TC using the EORTC QLQ‐TC26 and analyzed the impact of treatment on sexual function in TC survivors.ResultsA total of 567 TC survivors responded to the EORTC QLQ‐TC26. Median age at the time of response was 43 years (interquartile range [IQR] 35–51 years), and median follow‐up period after treatment was 5.2 years (IQR 2.2–10.0 years). Sexual function, particularly ejaculatory function, was significantly lower after post‐chemotherapy retroperitoneal lymph node dissection (PC‐RPLND) than after Surveillance or Chemotherapy groups (p < 0.05). In the PC‐RPLND group, nerve‐sparing procedure preserved postoperative ejaculatory function after RPLND compared with the non‐nerve‐sparing and offered improved ejaculatory function with time. On multivariate analysis, RPLND was a significant predictor of post‐treatment ejaculatory dysfunction, particularly without nerve‐sparing (odds ratio 3.0, 95% CI 1.2–7.7, p < 0.05). In addition, TC survivors with nerve‐sparing RPLND had higher sexual activity than those without.ConclusionThis survey of the EORTC QLQ‐TC26 showed that sexual function and activity in TC survivors after RPLND was reduced in the absence of nerve‐sparing techniques.
Recent advancements in the diagnosis and treatment of non‐muscle invasive bladder cancer: Evidence update of surgical concept, risk stratification, andBCG‐treated disease
Authors: Miyake Makito , Nishimura Nobutaka , Fujii Tomomi , Fujimoto Kiyohide 
Published: July 2023

AbstractIn the management of non‐muscle invasive bladder cancer (NMIBC), disease progression and long‐term control are determined by the intensity of delivered treatment and surveillance and the cancer cells' biological nature. This requires risk stratification–based postoperative management, such as intravesical instillation of chemotherapy drugs, Bacillus Calmette–Guérin (BCG), and radical cystectomy. Advancements in mechanical engineering, molecular biology, and surgical skills have evolved the clinical management of NMIBC. In this review, we describe the updated evidence and perspectives regarding the following aspects: (1) advancements in surgical concepts, techniques, and devices for transurethral resection of the bladder tumor; (2) advancements in risk stratification tools for NMIBC; and (3) advancements in treatment strategies for BCG‐treated NMIBC. Repeat transurethral resection, en‐bloc transurethral resection, and enhanced tumor visualization, including photodynamic diagnosis and narrow‐band imaging, help reduce residual cancer cells, provide accurate diagnosis and staging, and sensitive detection, which are the first essential steps for cancer cure. Risk stratification should always be updated and improved because the treatment strategy changes over time. The BCG‐treated disease concept has recently diversified to include BCG failure, resistance, refractory, unresponsiveness, exposure, and intolerance. A BCG‐unresponsive disease is an extremely aggressive subset unlikely to respond to a rechallenge with BCG. Numerous ongoing clinical trials aim to develop a future bladder‐sparing approach for very high‐risk BCG‐naïve NMIBC and BCG‐unresponsive NMIBC. The key to improving the quality of patient care lies in the continuous efforts to overcome the clinical limitations of bedside management.
COVID‐19 coping experiences of individuals with schizophrenia: A grounded theory approach in Korea
Authors: Shin Soyoung , Joung Jaewon 
Published: July 2023

AbstractHumankind has responded to the profound medical, economic, social, and cultural consequences of coronavirus disease 2019 (COVID‐19) by employing various strategies. However, although individuals with mental disorders, including schizophrenia, have suffered more challenges from the infectious disease spread, they have received inadequate attention and care. Hence, this study aimed to explore the experiences of individuals with schizophrenia coping with COVID‐19; one‐to‐one interviews were conducted with 17 individuals diagnosed with schizophrenia in Korea. The data were analysed using grounded theory methodology. The results showed that individuals with schizophrenia became distanced from the routine care they received before COVID‐19, faced a dual threat from their mental illness and the emerging infectious disease, and experienced inequity and paradoxical situations. Nevertheless, they strived to live their daily lives by utilizing non‐face‐to‐face access, seeking support from mental health professionals, and devising self‐help measures. Moreover, reflecting on their lives throughout the pandemic after returning to their regular daily lives provided an opportunity for healing and growth. This study's results can provide evidence for treating individuals with schizophrenia and other mental disorders during subsequent infectious disease spread. Practical policies and interventions tailored to their vulnerabilities are required.
Racial microaggressions: Identifying factors affecting perceived severity and exploring strategies to reduce harm
Authors: Jenkins Michael , Deol Amitoze , Irvine Alexandra , Tamburro Meagan , Qiu Jessica , Obhi Sukhvinder S. 
Published: July 2023

AbstractMicroaggressions are speech or actions constituting indirect, subtle, or unintentional acts of discrimination, and awareness of their harmful effects has grown in recent years. Increased awareness could improve inter‐group interactions, but also poses challenges. Fear of misspeaking, or fear of being subject to microaggressions can stifle interactions. We investigated how people from different racial and ethnic groups and political orientations judge the severity of various forms of racial microaggressions, and we tested a specific strategy to mitigate the harm of racial microaggressions. Specifically, in Experiment 1, White participants (WP) and participants of colour (POC) rated the severity of various microaggressions (depicted in vignettes). Participants also reported their political orientation and strength of racial/ethnic identity. Regardless of racial/ethnic group, left‐leaning political orientation was associated with higher perceived severity of racial microaggressions. Furthermore, severity ratings from POC were higher for those who identified more strongly with their ethnic/racial group. In Experiment 2, we again obtained severity ratings, but we used microaggression vignettes that were manipulated to reveal the source s mindset as either reparatory and open‐minded (ROM), or not. Critically, severity ratings were significantly lower for vignettes in which ROM was messaged. The importance of these results is twofold. First, they reveal that political orientation can override other factors like racial group membership when judging the severity of racial microaggressions, and second, they show that augmenting problematic speech with information about mindset, can mitigate perceived harm. Overall, this work contributes to a richer understanding of microaggressions, and has implications for theory and practice.
Organizational nostalgia as a novel pathway toward greater employee well‐being
Authors: Kawasaki Shota , Zou Xi , Wildschut Tim , Sedikides Constantine 
Published: July 2023

AbstractEmployee well‐being is a critical consideration for organizations. It may be particularly so in the post COVID‐19 era, where many still suffer from the pandemic's after‐effects. We propose a novel pathway to maintain and improve employee well‐being: organizational nostalgia, one's sentimental longing or wistful affection for past organizational events. We advocate that organizational nostalgia is associated with job satisfaction and organizational commitment and that telecommuting frequency (i.e., the extent to which employees work remotely) moderates this association. Additionally, we examine employees' perceptions of organizational cultural strength as an antecedent of organizational nostalgia. Findings from two studies support our theoretical proposals and offer fresh insight into how organizations could sustain their employees' well‐being by leveraging organizational nostalgia.
Cardiac resynchronization therapy in patients with a prior history of atrial fibrillation: Insights from four major clinical trials
Authors: Dalgaard Frederik , Fudim Marat , Al‐Khatib Sana M. , Friedman Daniel J. , Abraham William T. , Cleland John G. F. , Curtis Anne B. , Gold Michael R. , Kutyifa Valentina , Linde Cecilia , Young James , Ali‐Ahmed Fatima , Tang Anthony , Olivas‐Martinez Antonio , Inoue Lurdes Y. T. , Sanders Gillian D. 
Published: July 2023

AbstractAimsTo investigate the association of cardiac resynchronization therapy (CRT) on outcomes among participants with and without a history of atrial fibrillation (AF).MethodsIndividual‐patient‐data from four randomized trials investigating CRT‐Defibrillators (COMPANION, MADIT‐CRT, REVERSE) or CRT‐Pacemakers (COMPANION, MIRACLE) were analyzed. Outcomes were time to a composite of heart failure hospitalization or all‐cause mortality or to all‐cause mortality alone. The association of CRT on outcomes for patients with and without a history of AF was assessed using a Bayesian‐Weibull survival regression model adjusting for baseline characteristics.ResultsOf 3964 patients included, 586 (14.8%) had a history of AF; 2245 (66%) were randomized to CRT. Overall, CRT reduced the risk of the primary composite endpoint (hazard ratio [HR]: 0.69, 95% credible interval [CI]: 0.56–0.81). The effect was similar (posterior probability of no interaction = 0.26) in patients with (HR: 0.78, 95% CI: 0.55–1.10) and without a history of AF (HR: 0.67, 95% CI: 0.55–0.80). In these four trials, CRT did not reduce mortality overall (HR: 0.82, 95% CI: 0.66–1.01) without evidence of interaction (posterior probability of no interaction = 0.14) for patients with (HR: 1.09, 95% CI: 0.70–1.74) or without a history of AF (HR: 0.70, 95% CI: 0.60–0.97).ConclusionThe association of CRT on the composite endpoint or mortality was not statistically different for patients with or without a history of AF, but this could reflect inadequate power. Our results call for trials to confirm the benefit of CRT recipients with a history of AF.
How therapists respond to “uneven” alliances in couple and family therapy: A conversation‐analytic study
Authors: Janusz Bernadetta , Pawelczyk Joanna , Józefik Barbara 
Published: July 2023

AbstractThis article examines how family and couple therapists respond to uneven alliances with their clients at the micro‐level of therapeutic exchanges in the context of Interpersonal Process Recall (IPR) interviews. We operationalize uneven alliance with the interactional concept of asymmetry of affiliation. To this end, first, using conversation analysis (CA), we identify episodes of asymmetry of affiliation in the moment‐by‐moment conversation between the therapist and the client in therapy consultation. Second, applying CA to the IPR interview data, we examine how therapists orient to the episodes of the session in which the asymmetry of affiliation was identified. The findings demonstrate therapists' two key practices of orienting to the episodes of asymmetry of affiliation: (1) therapists' exclusive identification with one participant by typically invoking gender roles and (2) therapists' investigation of their agency in the emergence of asymmetry.
Impact of diagnosis and treatment of uterine fibroids on quality of life and labor productivity: The Japanese online survey for uterine fibroids and quality of life (JOYFUL survey)
Authors: Koga Kaori , Fukui Motoko , Fujisawa Masaki , Suzukamo Yoshimi 
Published: July 2023

AbstractAimTo investigate the impact of uterine fibroid diagnosis/treatment status on quality of life (QOL) and work productivity in women living in Japan.MethodsWomen aged 20–49 years who registered on Macromill were recruited via the opt‐in method. They completed an online survey on demographic and uterine fibroid diagnosis/treatment status, 36‐Item Short‐Form Health Survey, Uterine Fibroid Symptom and Health‐Related Quality of Life questionnaire (UFS‐QOL), and World Health Organization Health and Work Performance Questionnaire.ResultsThere were 4120 respondents: 1362 untreated, 249 with ongoing treatment, 449 with past treatment, 1030 with no uterine fibroids, and 1030 with unknown uterine fibroid status. A high proportion of women with ongoing treatment had moderate to severe uterine fibroid‐like symptoms (symptom severity score of UFS‐QOL ≥40 points), accompanied by reduced QOL. QOL was improved in women with past treatment. Uterine fibroids had a significant impact on physical and psychosocial aspects in the ongoing treatment group versus other groups. Using classification and regression tree analysis, anemia was identified as a plausible predictor of reduced QOL in the ongoing treatment group. Approximately 20% of women—even in groups other than the ongoing treatment group—experienced moderate to severe uterine fibroid‐like symptoms. However, the diagnosis and treatment status of uterine fibroids had no clear impact on work productivity.ConclusionsUterine fibroids, especially in association with anemia, were related to reduced QOL. Given that uterine fibroid‐related reduced QOL is likely improved by appropriate treatment, women with uterine fibroid‐like symptoms, such as menorrhagia, should be examined and treated.
Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia
Authors: Hepworth‐Warren Kate L. , Estell Krista , Cowles Bobby , Amodie Deborah , Crisman Mark 
Published: July 2023

AbstractBackgroundSerum amyloid A (SAA) is a major acute phase protein in horses which could be a useful tool for assessing clinical response to treatment of bacterial pneumonia in adult horses.ObjectivesTo monitor SAA concentration in response to treatment and identify associations among SAA concentration, WBC and neutrophil counts, and fibrinogen in bacterial pneumonia in adult horses.AnimalsEighteen adult horses with bacterial pneumonia.MethodsProspective clinical study. Horses hospitalized with bacterial pneumonia were enrolled and SAA concentration and vital signs were assessed daily. SAA concentration was measured by a handheld meter. CBC and plasma fibrinogen were assessed on days 0, 1, and 2, then every 3 days until discharge. Data were not normally distributed and therefore were log transformed. Log‐transformed data were analyzed and comparisons were performed on LSMeans by the 2‐sided Student's t‐test at the 5% level of significance.ResultsGeometric mean SAA concentration on day 0 was 537 μg/mL (SE 383 μg/mL). Geometric mean SAA concentration decreased significantly over time (P = .0001), peaking at day 2 (geomean 1038 μg/mL, SE 261.7 μg/mL) and decreasing until discharge. Plasma concentration of fibrinogen (P = .06), neutrophil count (P = .48), and WBC count (P = .07) did not change significantly over time.Conclusions and Clinical ImportanceSAA concentration decreased significantly over the course of treatment and correlated with clinical improvement of pneumonia whereas fibrinogen, neutrophil, and WBC counts did not.