bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implantação do processo de sucessão em uma empresa familiar de transportes: desafios e contradições
Authors: De Almeida Edson Rodrigo , Melo Marlene Catarina de Oliveira Lopes Melo 
Published: September 2023

Este artigo apresenta uma pesquisa denominada “Estado do Conhecimento” sobre a temática “Ensino Híbrido”. Objetiva encontrar subsídios teóricos para um novo estudo, no sentido de não só compreender melhor a temática, como também buscar auxílio para decisões metodológicas de uma pesquisa maior. As buscas foram realizadas nas plataformas BDTD e Google Scholar, a partir do termo indutor “Ensino Híbrido”. Após a utilização de alguns filtros, dentre eles o recorte temporal entre 2015 e 2020, foram encontradas 415 produções e destas foram selecionadas 21 para compor o corpus do “Estado do Conhecimento”. Os resultados mostram que a maioria das pesquisas associa o ensino híbrido à formação de professores, considerando o desenvolvimento de habilidades ligadas às tecnologias de informação. Assim, tanto a formação de professores quanto as habilidades para lidar com as tecnologias passam a ser questões norteadoras para a pesquisa maior.
The Survival Rate and Growth of Grafted-Seedling of Durian (Durio zibethinus Murr.) Using 3 Rootstocks Ages and 3 Levels of Scion Buds
Authors: Asmawati  , Inderiati Sitti , Hambali Amriani 
Published: September 2023

This experiment was performed to determine the survival rate of grafted-seedling growth of durians using various ages of rootstocks and different numbers of scion buds. The study was arranged in a two-factorial randomized block design with three replications. The first factor was rootstock age (4, 6, and 8 weeks) and the second factor was the number of buds on the scion (1, 2, and 3 buds). The percentage of the successful grafting and several growth parameters, i.e., time of bud break, length and diameter of new shoots were evaluated for three months. Data were analysed using analysis of variance and continued with the post-hoc Tukey’s test. The results showed that age of rootstock did not affect percentage of successful grafting, time of budburst, shoot length and shoot diameter. Likewise, the number of shoots did not affect the percentage of successful grafting, shoot length, and shoot diameter, but had a significant effect on bud bursting time (P<0.05). Scion that had three buds resulted in the fastest time of bud break (28.45 days). The highest percentage of successful graft union was in the 4-week-old rootstock and scion with 2 and 3 buds (100%), the maximal successful also obtained in the 6-week-old rootstocks with 3 buds. The four-week-old rootstocks also gave the best result in the new shoot length and diameter. Nevertheless, there was no interaction between rootstock age and the number of buds on scion in survival rate of grafted seedlings of durian.
Comprehensive assessment reveals numerous clinical and neurophysiological differences between MECP2‐allelic disorders
Authors: Pehlivan Davut , Huang Chengjun , Harris Holly K. , Coquery Christine , Mahat Aditya , Maletic‐Savatic Mirjana , Mignon Laurence , Aras Sukru , Glaze Daniel G. , Layne Charles S. , Sahelijo Leonardo , Zoghbi Huda Y. , McGinley Matthew J. , Suter Bernhard 
Published: January 2025

AbstractObjectiveRett syndrome (RTT) and MECP2 duplication syndrome (MDS) result from under‐ and overexpression of MECP2, respectively. Preclinical studies using genetic‐based treatment showed robust phenotype recovery for both MDS and RTT. However, there is a risk of converting MDS to RTT, or vice versa, if accurate MeCP2 levels are not achieved. The aim of this study was to identify biomarkers distinguishing RTT from MDS.Materials and MethodsWe prospectively enrolled 11 MDS and 6 male RTT like (MRL) individuals for a panel of clinical and neurophysiological assessments over two visits, 8–10 months apart.ResultsWe identified numerous clinical and physiological features as promising biomarkers. MRL individuals exhibited large amplitude whole body tremor, midline stereotypies (vs. hand flapping at sides in MDS), earlier neuromotor regression, and earlier onset but less commonly refractory epilepsy. In the neurophysiological domain, we observed several marked differences in sleep physiology between MDS/MRL and typically developing (TD) individuals including reduced sleeping time, increased delta power during rapid eye movement (REM) sleep, decreased occipital alpha and increased brain‐wide delta power during wakefulness, and reduced spindle density and duration. MRL individuals also had much lower delta power during NREM 2 and 3 stages than the TD group. We found differences in spindle duration in the temporal lobes and spindle amplitude in the frontal lobes between MDS and MRL.DiscussionOur study revealed distinct clinical features of MDS and MRL that can be monitored during a clinical trial and may serve as target engagement, disease progression, or safety biomarkers for interventional studies.
Weaving Bonds: Constructing a Model to Unveil the Role of Relationship Memories in Satisfaction
Authors: Koc‐Arik Gizem , Ozdes Aylin 
Published: January 2025

ABSTRACTRelationship satisfaction is closely tied to various characteristics of recollected past events within romantic relationships. However, our understanding of how distinct characteristics of these memories, individually and collectively are related to satisfaction remains limited. This study aimed to explore the associations between these characteristics and examine their role in relationship satisfaction. Participants recalled two memories from their relationships and rated the memory characteristics. The results revealed relationships between event characteristics and both rehearsal and recollection. Yet, rehearsal did not mediate the relationship between event characteristics and recollection. When relationship satisfaction was incorporated into the model, negative events marked by high emotion and personal significance, were related to increased rehearsal frequency, which in turn was associated with lower relationship satisfaction. However, personally significant negative events also enhanced recollective features, which heightened relationship satisfaction. These findings highlight the crucial role of relationship memories in relationship satisfaction, especially for the negative events.
The False Balance Effect: Exploring Partition Dependence as a Potential Explanation
Authors: Han Tianshuang , Snook Brent , Day Martin V. 
Published: January 2025

ABSTRACTFalse balance arises when opposing viewpoints about a scientific issue are portrayed as more evenly matched than what the empirical evidence demonstrates. We examined the extent to which partition dependence is the psychological mechanism underlying the false balance effect. Participants (N = 360) read a statement about an interrogation practice (i.e., the use of false evidence ploys) that reached expert consensus, viewed data about the level of the expert consensus, and then assigned randomly to view (a) balanced expert comments in equal proportion on each side (3:3), (b) two‐sided comments with more consensus views (5:1), (c) two‐sided comments with more contrarian views (1:5), or (d) no comments at all. Results showed that balanced comments distorted perceived expert consensus and that two‐sided comments with more consensus views had the largest impact on debiasing perceived expert consensus. We discuss the implications of our findings for science communication efforts.
Multidirectional Reorientation in the Ferroelastic van der Waals Semimetal Molybdenum Ditelluride
Authors: Kim Hyeon‐Sik , Koh Woochan , Kwon Gihyeon , Jeong Kwangsik , Jang Myeongjin , Lee Han Joo , Park Hyunjun , Kim Kwanpyo , Jeong Jaehun , Im Seongil , Cho Mann‐Ho 
Published: January 2025

AbstractFerroelastic properties in two‐dimensional materials have garnered significant attention due to their potential to control structural anisotropy, thereby influencing optical and electrical characteristics under external stress. Despite these potential applications, there remains a scarcity of reports on ferroelastic behavior in two‐dimensional van der Waals materials. In this study, we investigate multidirectional ferroelastic reorientation in the two‐dimensional van der Waals semimetallic phase of Molybdenum ditelluride (1T′ MoTe2). Employing a polymer encapsulation method, ferroelastic switching in 1T′ MoTe2 is examined via real‐time polarized optical imaging under uniaxial strain. Polarized Raman spectroscopy confirms the orientation of Mo–Mo chains in original and reoriented domains, revealing 120° rotational switching in reconstructed domains. Analysis using selective area electron diffraction and scanning transmission electron microscopy elucidate the atomic arrangements of original and reconstructed domains, including domain wall structures. Additionally, it is demonstrated that external uniaxial strain can differentiate between the stabilities of three equivalent states in 1T′ MoTe2, enabling manipulation of the orientation of Mo–Mo chains based on the direction of the applied strain. The findings highlight the capability for multidirectional ferroelastic reorientation in the two‐dimensional semimetal MoTe2 through the application of uniaxial strain.
High‐Purity Photoactive α‐Phase for Flexible Perovskite Photodetectors with Modified Electron Transport Layer
Authors: Hu Ying , Zhang Xinyu , Mo Xiaoliang , Chu Junhao , Fang Xiaosheng , Li Ziqing 
Published: January 2025

AbstractRegulating the crystallization process of organic–inorganic halide perovskite is essential for the fabrication of reproducible and efficient optoelectronic devices. Herein, a vacuum‐assisted heating treatment strategy for precursor is developed to obtain a high‐purity photoactive phase perovskite. By eliminating residual H2O molecules from raw materials and solvents, the method prevents the Pb–I framework of perovskite from being destroyed. Additionally, the pre‐treated precursor possesses high‐valence iodoplumbate species leading to preferable crystallization for perovskite films. Furthermore, a high on‐off ratio of 1103 is attained under 0 V and 550 nm illumination by employing a vertical n–i–p photodetector based on pure 𝛼‐phase perovskite films and interface passivation carried out by incorporating phenethylammonium hydroiodide (PEAI) in the n‐type electron transport layer. The photodetector exhibits high sensitivity with the peak responsivity of 0.93 A W−1 and the detectivity of 1.55 × 1012 Jones in the visible light range, making it a potential candidate for an imaging application. The flexible photodetector fabricated on polyethylene terephthalate (PET) substrate maintains 98.6% photocurrent density after 300 times of bending and preliminarily realizes imaging sensing. The heat‐treating strategy improves the adaptability of perovskite to complex environments and enables the preparation of reproducible pure 𝛼‐phase perovskite films, which boast enormous potential for optoelectronic applications.
Wearable Pressure Sensor Based on Triboelectric Nanogenerator for Information Encoding, Gesture Recognition, and Wireless Real‐Time Robot Control
Authors: Guo Mengjia , Xia Yifan , Liu Jiaxuan , Zhang Yinghao , Li Min , Wang Xin 
Published: January 2025

AbstractWearable sensor has attracted a broad interesting in application prospect of human‐machine interaction (HMI). However, most of sensors are assembled in the shape of gloves to accurately capture complex hand motion information, thereby seriously blocking the hand to complete complex tasks. Herein, a wearable pressure sensor based on drum‐structured triboelectric nanogenerator (DS‐TENG) is developed to capture subtle pressure signals for physiological signal detection, information encoding, gesture recognition, and wireless real‐time robot control. The DS‐TENG enables a limit of detection down to 3.9 Pa pressure, which can sensitively capture human micromotion signals of pulse, throat sounds, and wrist muscles contraction. Especially, combined with a microprocessor and Morse code, the DS‐TENG worn on wrist can detect single‐finger motion signals to translate into regular voltage signals, which is employed to encode information of 26 letters and subsequently decode into the corresponding letters. Furthermore, with an aid of machine learning, the DS‐TENG array (2 × 2) can successfully achieve gesture recognition with high accuracy of 92% to wirelessly perform real‐time robot control. Consequently, the wearable pressure sensor based on DS‐TENG can capture subtle pressure signals for information encoding and wireless real‐time robot control, which demonstrates extreme potential in the field of HMI and artificial intelligence.
Rigid Fluorescent Indacenetetraone‐Based Semiconducting Polymers via Knoevenagel Condensation
Authors: Kang So‐Huei , Ghamari Pegah , Ruchlin Cory , Che Yuxuan , He Zhechang , Chan Quentin , Rosei Federico , Perepichka Dmytro F. 
Published: January 2025

AbstractThe synthesis of new donor‐acceptor polymers is reported through Knoevenagel condensation of indacenetetraone with aromatic dialdehydes. The obtained polymers possess exceptionally rigid planar backbones with a rotational barrier (for single C─C bonds) of 16–20 kcal mol−1, the highest among known conjugated polymers. These structural features confer several unusual properties, including remarkably narrow absorption bands with very high absorption coefficient (up to ≈3×105 cm−1) and efficient fluorescence in the red to near‐IR region (λmax 694–850 nm, quantum yield 10–29%). Systematic spectroscopic, electrical, and microstructural characterization supported by Density Functional Theory (DFT) calculations reveals the effects of heteroatoms and the conjugation lengths on the optoelectronic properties of these materials. The polymers exhibit ambipolar charge transport in field‐effect transistors, which can be tailored to show unipolar p‐type (0.1 cm2 V−1 s−1) and n‐type (0.05 cm2 V−1 s−1) behavior by adjusting the energy levels at the polymer/metal contacts. Additionally, their application is demonstrated as acceptors in all‐polymer organic photovoltaic devices with commercial donor polymers, achieving a power conversion efficiency (PCE) of 11%.
Navigating Tumor Microenvironment Barriers with Nanotherapeutic Strategies for Targeting Metastasis
Authors: Thomas Mahima Rachel , Badekila Anjana Kaveri , Pai Vishruta , S Nijil , Bhandary Yashodhar , Rai Ankit , Kini Sudarshan 
Published: January 2025

AbstractTherapeutic strategy for efficiently targeting cancer cells needs an in‐depth understanding of the cellular and molecular interplay in the tumor microenvironment (TME). TME comprises heterogeneous cells clustered together to translate tumor initiation, migration, and proliferation. The TME mainly comprises proliferating tumor cells, stromal cells, blood vessels, lymphatic vessels, cancer‐associated fibroblasts (CAFs), extracellular matrix (ECM), and cancer stem cells (CSC). The heterogeneity and genetic evolution of metastatic tumors can substantially impact the clinical effectiveness of therapeutic agents. Therefore, the therapeutic strategy shall target TME of all metastatic stages. Since the advent of nanotechnology, smart drug delivery strategies are employed to deliver effective drug formulations directly into tumors, ensuring controlled and sustained therapeutic efficacy. The state‐of‐the‐art nano‐drug delivery systems are shown to have innocuous modes of action in targeting the metastatic players of TME. Therefore, this review provides insight into the mechanism of cancer metastasis involving invasion, intravasation, systemic transport of circulating tumor cells (CTCs), extravasation, metastatic colonization, and angiogenesis. Further, the novel perspectives associated with current nanotherapeutic strategies are highlighted on different stages of metastasis.
Sargassum Nanocellulose‐Based Fully Ingestible Supercapacitor
Authors: He Qian , Ling Zhang‐Chi , Li De‐Han , Yang Kun‐Peng , Yang Huai‐Bin , Yan Zheng‐Kun , Han Zi‐Meng , Zhao Yu‐Xiang , Yin Chong‐Han , Guan Qing‐Fang , Yu Shu‐Hong 
Published: January 2025

AbstractSmall high‐performance energy modules have significant practical value in the biomedical field, such as painless diagnosis, alleviation of gastrointestinal discomfort, and electrical stimulation therapy. However, due to performance limitations and safety concerns, it is a formidable challenge to design a small, emerging ingestible power supply. Here, a fully ingestible supercapacitor (FISC) constructed of sargassum cellulose nanofiber is presented. FISCs exhibit an electrode areal capacitance of 2.29 F cm−2 and a high energy density of 307 µWh cm−2. Furthermore, over 90% of the antibacterial activity against Escherichia coli is achieved during the self‐discharge process. Therefore, following insertion into an enteric capsule, this device can enable a disposable power supply and electrostimulation for bacteriostasis in the intestine after being swallowed by a human, which offers new possibilities for scientific and simple therapy.
Co(III)‐Catalyzed Regioselective C−H Dienylation of Indolines and Indoles with Allenyl Carbinol Acetates
Authors: Shukla Rahul K. , Singh Anurag , Shetty Rakesh , Volla Chandra M. R. 
Published: January 2025

AbstractHerein, we present a Co(III)‐catalyzed regioselective C7‐H dienylation of indolines at room temperature employing allenyl carbinol acetate as an efficient dienylating reagent. The reaction proceeds via C−H activation, regioselective 2,1‐migratory insertion of the allene followed by β‐acetate elimination, resulting in a diverse array of C7‐dienylated indolines. The methodology was further extended to C2‐H dienylation of indoles, affording either branched or linear dienes, contingent on the nature of the substituent present at the allenylic carbon. In addition, hydroarylation of allenes was also successfully achieved with tri‐substituted allenes, which was elusive so far under cobalt catalysis.
Scalable Electrochemical Dehalogenative Carboxylation without a Sacrificial Metal Anode
Authors: Petrovic Nikola , Laudadio Gabriele , Salazar Chase A. , Kong Caleb J. , Verghese Jenson , Hesketh Alexander , Reyes Giselle P. , Desrosiers Jean‐Nicolas , Oliver Kappe C. , Cantillo David 
Published: January 2025

AbstractA scalable electrochemical procedure for the synthesis of carboxylic acids from organic halides has been developed using a spinning cylinder electrode electrochemical reactor. The electrochemical process is based on the reductive dehalogenation of the starting material followed by trapping of the resulting carbanion with CO2. The protocol is compatible both with organic chlorides and bromides and uses inexpensive graphite and stainless steel as electrode materials. As sacrificial metal anodes are avoided, the method can be readily scaled up in flow mode. The procedure is compatible with a wide range of substrates (24 examples), including aryl and alkyl halides as well as heterocyclic compounds. Multigram scale preparations in flow mode have been demonstrated by processing 600 mL of reaction mixture in an electrolyte recirculation setup.
The Metabolite Indole‐3‐Acetic Acid of Bacteroides Ovatus Improves Atherosclerosis by Restoring the Polarisation Balance of M1/M2 Macrophages and Inhibiting Inflammation
Authors: Liu Wu , Wang Jingyu , Yang Heng , Li Congcong , Lan Wanqi , Chen Tingtao , Tang Yanhua 
Published: January 2025

AbstractEmerging research has highlighted the significant role of the gut microbiota in atherosclerosis (AS), with microbiota‐targeted interventions offering promising therapeutic potential. A central component of this process is gut‐derived metabolites, which play a crucial role in mediating the distal functioning of the microbiota. In this study, a comprehensive microbiome‐metabolite analysis using fecal and serum samples from patients with atherosclerotic cardiovascular disease and volunteers with risk factors for coronary heart disease and culture histology is performed, and identified the core strain Bacteroides ovatus (B. ovatus). Fecal microbiota transplantation experiments further demonstrated that the gut microbiota significantly influences AS progression, with B. ovatus alone exerting effects comparable to volunteer feces from volunteers. Notably, B. ovatus alleviated AS primarily by restoring the intestinal barrier and enhancing bile acid metabolism, particularly through the production of indole‐3‐acetic acid (IAA), a tryptophan‐derived metabolite. IAA inhibited the TLR4/MyD88/NF‐κB pathway in M1 macrophages, promoted M2 macrophage polarisation, and restored the M1/M2 polarisation balance, ultimately reducing aortic inflammation. These findings clarify the mechanistic interplay between the gut microbiota and AS, providing the first evidence that B. ovatus, a second‐generation probiotic, can improve bile acid metabolism and reduce inflammation, offering a theoretical foundation for future AS therapeutic applications involving this strain.
Phonon Involved Photoluminescence of Mn2+ Ions Doped CsPbCl3 Micro‐Size Perovskite Assembled Crystals
Authors: Gao Jialiang , Guo Yangyang , Zhang Xiuhai , Liu Lu , Li Huixin , Cheng Zeyi , Liu Peng , Dong Fan , Wu Jiandong , Liu Taihong , Sun Huaming , Zhang Miao , Aubin Hervé , Wang Hongyue , Wang Hongqiang 
Published: January 2025

AbstractMn2+ ions doped CsPbCl3 perovskite nanocrystals (NCs) exhibit superiority of spin‐associated optical and electrical properties. However, precisely controlling the doping concentration, doping location, and the mono‐distribution of Mn2+ ions in the large‐micro‐size CsPbCl3 perovskite host is a formidable challenge. Here, the micro size CsPbCl3 perovskite crystals (MCs) are reported with uniform Mn2+ ions doping by self‐assembly of Mn2+ ions doped CsPbCl3 perovskite NCs. The electron–phonon coupling strength is enhanced in the perovskite self‐assembled CsPbCl3 MCs, which remarkably accelerates the PL decay of Mn2+ ions in room temperature. Furthermore, the phonon‐involved PL emission splits to two peaks at low temperature of 80 K, due to the phonon emission and absorption‐induced energy exchange for exciton recombination in Mn2+ ions. These findings not only demonstrate a novel material system but also introduce a new theoretical framework for phonon‐modulated PL manipulation in Mn2+‐doped perovskite materials.
Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression
Authors: Wang Jing , Yu Weiqiang , Shen Hui , Sang Yanxiang , Zhang Hongjie , Zheng Benyan , Peng Xue , Hu Yuan , Ma Xiaopeng , Yang Zhenye , Yu Fazhi 
Published: January 2025

AbstractBlack phosphorus (BP) has demonstrated potential as a drug carrier and photothermal agent in cancer therapy; however, its intrinsic functions in cancer treatment remain underexplored. This study investigates the immunomodulatory effects of polyethylene glycol‐functionalized BP (BP‐PEG) nanosheets in breast cancer models. Using immunocompetent mouse models‐including 4T1 orthotopic BALB/c mice and MMTV‐PyMT transgenic mice, it is found that BP‐PEG significantly inhibits tumor growth and metastasis without directly inducing cytotoxicity in tumor cells. Mass cytometry analysis reveals that BP‐PEG reshapes the tumor immune microenvironment by recruiting neutrophils. Neutrophil depletion experiments further demonstrate that the antitumor effects of BP‐PEG are dependent on neutrophils. Moreover, bulk and single‐cell RNA sequencing indicate that BP‐PEG is mainly taken up by macrophages, leading to the release of inflammatory factors such as IL1A and CXCL2, which enhance neutrophil recruitment and activation, thereby amplifying the antitumor immune response. Finally, co‐culture assays confirm that BP‐PEG indeed enhances the antitumor activity of neutrophils and natural killer (NK) cells. These findings position BP‐PEG as an immunomodulatory agent capable of reprogramming the tumor microenvironment to promote innate immunity against breast cancer. By stimulating neutrophil‐mediated antitumor activity, BP‐PEG offers a unique therapeutic approach that can potentially enhance the efficacy of existing cancer immunotherapies.