bluuebunny/crossref_metadata_2025_split huggingface dataset:
RNNHC: A hybrid error correction algorithm for long reads based on Recurrent Neural Network
Authors: Wang Rongshu , Chen Jianhua 
Published: September 2023

Abstract
Long reads generated by third-generation sequencing technologies show irreplaceable advantages in downstream analysis by virtue of their ultra-long read lengths. However, their high error rate also affects the accuracy of downstream analysis. Meanwhile, deep learning has shown its talents in the processing of long gene sequence problems. In this work, a hybrid error correction algorithm is proposed, which uses the idea of processing multi-class tasks with a recurrent neural network to capture the long-term dependencies in the long reads to solve the problem of long-read error correction. RNNHC first aligns the long reads to the high-precision short reads to generate the corresponding feature vectors and labels, then adopts a recurrent neural network to capture the dependencies between bases, and finally trains the model so that it can be used later for prediction and error correction. We demonstrate that the performance of RNNHC is better than that of state-of-the-art hybrid error correction methods on real-world PacBio and ONT data sets including E. coli, S. cerevisiae, and Drosophila melanogaster. As shown in our experimental results that RNNHC can improve the alignment identity while maintaining read length and continuity of the sequence, and spending less user time than other hybrid error correction algorithms. Furthermore, RNNHC is applicable to data from two mainstream sequencing platforms.
Dignity Preservation Among Hospitalized Patient: A Case study of Bugando Medical Centre, Northwestern Tanzania
Authors: Mabega Ndakibae Gabriel , Mwaisungu Halima , Mwing’a Gerald Phares , Razaro Haule AS 
Published: September 2023

Abstract
Background Dignity preservation is regularly emphasized as one of the basic patient rights in both national and international codes of ethics in medical practices. Therefore, it is important to explore this concept based on the patient's experience to maintain and respect their dignity, improve the quality of health services, and increase patient satisfaction in health care.Material and Methods This was a qualitative descriptive study in which 20 hospitalized patients were recruited. Purposive sampling was used to select study participants from wards of different departments of Bugando Medical Centre (BMC). Patients were interviewed about the experience related to the preservation of their dignity during their hospital stay. Data were analyzed using qualitative content analysis.Aim The study aimed to explore the experience of dignity preservation among hospitalized patients during their hospital stay.Results Four major themes emerged from the analysis of the data obtained from the interview. Patient-Provider relationship, patient involvement in treatment plan, Inadequate privacy and confidentiality, Accessibility and Affordability of health services.Conclusion From the patient’s experience, human dignity needs to be preserved and maintained in hospitals. Respect for their privacy, confidentiality, and patient involvement in the treatment plan should be taken into consideration.
Enhanced solar-driven evaporation and mineral extraction from hypersaline produced water using low-cost microporous photothermal foam
Authors: Nnanna Agbai (George) , Nnanna Nnenne 
Published: September 2023

Abstract
The beneficial reuse of produced water (PW) holds significant promise to alleviate water scarcity. However, it still suffers major limitations associated with high cost of treatment due to energy consumption, economics of scale, and the complex physiochemical constituents. PW is a hypersaline (TDS ~ 250,000 mg/l) oilfield water with bio-species, organic matters, anions, divalent cations, and radioactive elements. A sustainable treatment option is a solar-driven floating photothermal evaporation (PTE), a desalination technology implemented for seawater characterized by simpler chemical compositions and low salinity. In this work, the photothermal evaporator for PW was fabricated using low cost commercially available charcoal polyurethane foam. The engineered macrochannels and structural alterations created unique pathways for salt extraction and evaporation; and ensured hydrodynamic balance between the rates of capillary flow and evaporation. This novel design mitigated flooding or dry out on the evaporating surface and kept the system running steadily while simultaneously harvesting freshwater and valuable salts. The key findings from this work are: (a) development of a novel temperature ratio-based method to determine optimum PTE thickness that results in maximum evaporation and thermal localization, (b) development of the first empirical correlation between the rate of thermal localization, evaporation rate, and PTE thickness. It combines the interplay of convection, evaporative flux, conduction, heat capacitance, and thickness on the thermal response of PTE foam to incident solar flux, and (c) experimental evidence revealing efflorescence and subflorescence salt on the evaporating surface and pore, and (d) enhanced evaporation rate of 118% or 71.6 kg/day- m2 of clean water from chemically-complex hypersaline produced water. These findings are significant for the engineering design and estimation of the performance of a PTE in a solar-driven evaporation system.
Comparing the Efficacy of Intravenous Morphine versus Ibuprofen or its Compound in Patients with Closed Limb Fractures
Authors: Isfahani Mehdi Nasr , Etesami Hossein , Ahmadi Omid , Masoumi Babak 
Published: September 2023

Abstract
Introduction:
This study aims to investigate the effectiveness of intravenous ibuprofen or intravenous ibuprofen plus acetaminophen compared to intravenous morphine in patients with closed extremity fractures.
Methods:
A triple-blinded randomized clinical trial was conducted at a tertiary trauma center in Iran. Adult patients between 15 and 60 years old with closed, isolated limb fractures and a pain intensity of at least 6/10 on the visual analog scale (VAS) were eligible. Patients with specific conditions or contraindications were not included. Participants were randomly assigned to receive intravenous ibuprofen, intravenous ibuprofen plus acetaminophen, or intravenous morphine. Pain scores were assessed using the visual analog scale at baseline and 5, 15, 30, and 60 minutes after drug administration. The primary outcome measure was the pain score reduction after one hour.
Results:
Out of 388 trauma patients screened, 158 were included in the analysis. There were no significant differences in age or sex distribution among the three groups. The pain scores decreased significantly in all groups after 5 minutes, with the morphine group showing the lowest pain score at 15 minutes. The maximum effect of ibuprofen was observed after 30 minutes, while the ibuprofen-acetaminophen combination maintained its effect after 60 minutes. One hour after injection, pain score reduction in the ibuprofen-acetaminophen group was significantly more than in the other two groups, and pain score reduction in the ibuprofen group was significantly more than in the morphine group.
Conclusion:
The study findings suggest that ibuprofen and its combination with acetaminophen have similar or better analgesic effects compared to morphine in patients with closed extremity fractures. Although morphine initially provided the greatest pain relief, its effect diminished over time. In contrast, ibuprofen and the ibuprofen-acetaminophen combination maintained their analgesic effects for a longer duration. The combination therapy demonstrated the most sustained pain reduction. The study highlights the potential of non-opioid analgesics in fracture pain management and emphasizes the importance of initiation of these medications as first line analgesic for patients with fractures. These findings support the growing trend of exploring non-opioid analgesics in pain management.
ClinicalTrials.gov Identifier: NCT05630222 (Tue, Nov 29, 2022)
Healing and long-term prognosis of root fractured permanent teeth: a retrospective longitudinal study
Authors: Pedrosa Natalia de Oliveira Murta , Santos Rayner Afonso , Coste Sylvia Cury , Colosimo Enrico Antônio , Bastos Juliana Vilela 
Published: September 2023

Abstract
Aim
The purpose of the present study was to evaluate permanent teeth with post-traumatic transversal root fractures for their initial healing modality, the effect of candidate predictors and their long term prognosis.
Methodology:
A retrospective longitudinal clinical study was conducted to evaluate records from patients bearing transversal root fractures in permanent teeth in order to radiographically assess short-term healing and non-healing events in the fracture line, their prognostic factors and their relationship with long term outcomes. The inter-fragmentary tissues were classified as healing: hard tissue (HT), connective tissue (CT) or connective tissue and bone (CT + B) and non-healing: interposition of granulation tissue (GT). A competing risk survival analysis was conducted to estimate the hazards of healing and non-healing events and the effect of demographic, clinical and treatment variables was assessed using the subdistribution regression model (Fine & Gray).
Results
Radiographic findings showed 51.9% of healing in the short-term being strongly influenced by the presence and type of concomitant injuries to the coronal fragment. Teeth with concomitant crown fractures (sHR 24.38, 95% CI [3.16–188.3], p = 0.0022), luxations with dislocations (sHR 10.58, 95% CI [1.37–81.9], p = 0.0240) and subluxations (HR 9.66, 95% CI [1.14–81.7], p = 0.0370) were more likely to present non-healing of root fractures in the short-term. The healing rate in the long-term was of 70.1%, most of them with interposition of bone and connective tissue. The only predictive factor for the long-term prognosis of root fractured tooth was the occurrence of short-term healing ((sHR 4.15 [2.15–8.01] p < 0.001).
Conclusion
Healing at the fracture site was the most frequent outcome, both in the short-term and in the long-term. Short-term healing modality was strongly influenced by the presence and type of concomitant injuries to the crown fragment and was also predictive for long-term prognosis.
Clinical relevance:
Post-traumatic transversal root fractures have a positive prognosis in the long-term, supporting therefore, a more conservative approach for these teeth before considering more radical treatments.
Identification of Some Priority Heavy Metals Driver of Environmental Degradation Caused by Agricultural Activity; A Case Study in Ebonyi State Nigeria
Authors: Igwe Emmanuel , Baharane Valérien , Ugwu Benedictha Chinenye , Diakite Simbo , Saquee Francess Sia , Usman John Julius 
Published: September 2023

Abstract

Agriculture operation remained the main emitter of top priority pollutants in the environment. This research identified actual agricultural activities that led to unabated emission heavy metal pollutant into the environment while signaling how it has contaminated agricultural yields. Descriptive statistic were used to analze quantification of the pollutants from various sources. It was reported non-sustainable agricultural operation is mother of all environmental issues verified with statistical data which showed it constituted (80%) caused ecological deterioration and deforestation. This study identified, atleast a majority (86%) of the farmers used agrochemical in their farming activities which has led to intensification of agriculture that triggered environmental degradation. Moreso, majority (88%) of the farmers used NPK fertilizer while 82% used ammonium nitrate fertilizer on their yields. It was reported that these chemical caused serious threat to life e.g N2O in particular in severe situation. The study identified, majority (75%) of the pollutants entered into the environment through erosion (leasing) of soil nutrients. The variants responsible for determining effects conventional approach to agricultural on the environment correlation relationship was tested with multiple regression analysis the was R2 82.6% which is statistically important variables that constituted the main sources of ecological crisis. The study recommended new orientation for more sustainable context approach to agriculture to produce health food and the ecosystem.
Application of a combined cancellous lag screw enhances the stability of locking plate fixation of osteoporotic lateral tibial plateau fracture by providing interfragmentary compression force
Authors: Jiang Jiang , Xu Daqiang , Wang Fei , Jia Rui , Wang Jun , Hong Hong , Zhang Hongtao , Li Jianyi 
Published: September 2023

Abstract
Background
Insufficient interfragmentary compression force (IFCF) frequently leads to unstable fixation of osteoporotic lateral tibial plateau fractures (OLTPFs). A combined cancellous lag screw (CCLS) enhances IFCF; however, its effect on OLTPF fixation stability remains unclear. Therefore, we investigated the effect of CCLS on OLTPF stability using locking plate fixation (LPF).
Methods
Twelve synthetic osteoporotic tibial bones were used to simulate OLTPFs, which were fixed using LPF, LPF-AO cancellous lag screws (LPF-AOCLS), and LPF-CCLS. Subsequently, 10,000 cyclic loadings from 30 to 400 N were performed. The initial axial stiffness (IAS), maximal axial micromotion of the lateral fragment (MAM-LF) measured every 1,000 cycles, and failure load after 10,000 cycles were tested. The same three fixations for OLTPF were simulated using finite element analysis (FEA). IFCFs of 0, 225, and 300 N were applied to the LPF, LPF-AOCLS, and LPF-CCLS, respectively, with a 1,000-N axial compressive force. The MAM-LF, peak von Mises Stress (VMS), peak equivalent elastic strain of the lateral fragment (EES-LF), and nodes of EES-LF > 2% (considered bone destruction) were calculated.
Results
Biomechanical tests revealed the LPF-AOCLS and LPF-CCLS groups to be superior to the LPF group in terms of the IAS, MAM-LF, and failure load (all p < 0.05). FEA revealed that the MAM-LF, peak VMS, peak EES-LF, and nodes with EES-LF > 2% in the LPF were higher than those in the LPF-AOCLS and LPF-CCLS.
Conclusions
IFCF was shown to enhance the stability of OLTPFs using LPF. Although there were no significant differences between the CCLS and AOCLS, CCLS is preferably recommended due to considerations regarding overscrewing.
Hybrid Booting with Incremental Hibernation for the Baseboard Management Controllers
Authors: Jang Joonhyouk , Park Minho , Hong Jiman 
Published: September 2023

Abstract
The Baseboard Management Controller (BMC) is a specialized processor installed on the motherboard of a server. The BMC operates independently from the server and provides administrators with functionalities for managing the server. Since the server boots immediately after the BMC is powered on, it is crucial to ensure rapid booting and backup of the BMC in case of failures like power outages or system crashes. This paper proposes a hybrid booting with the incremental hibernation technique, considering the operating environment of the BMC. The proposed technique periodically stores the state of the BMC and offers various recovery options based on the stored state. It also employs an incremental backup technique for the efficient management of stored states and a hybrid booting technique to guarantee fast booting. In order to evaluate the performance of the proposed technique, the proposed technique is implemented on a development board where the BMC chipset operates, and the overhead, disk usage, and booting speed are measured. The experimental results show that the proposed technique efficiently enables BMC backup and reduces the booting times.
Improvement of laparoscopic inguinal lymph node dissection for Penile cancer
Authors: ban yifei , xu faren , liang tiejun , yang nannan 
Published: September 2023

Abstract
The prognosis of Penile cancer patients is closely related to the metastasis of inguinal lymph nodes. Timely inguinal lymph node dissection is an important part of the treatment of Penile cancer. The tumor control effect of laparoscopic inguinal lymph node dissection is similar to that of open surgery, but the complications are significantly reduced; And there are different methods in terms of surgical approach, dissection approach and Great saphenous vein preservation. We adopt the transabdominal subcutaneous anterograde approach and improve the laparoscopic inguinal lymph node dissection. This article introduces the procedures and technical improvement points of the improved laparoscopic inguinal lymph node dissection through the subcutaneous approach.
Key-in-Session Identity Negotiations in a First Line Treatment for Adult Anorexia Nervosa
Authors: Heywood Lauren , Conti Janet , Hay Phillipa , Touyz Stephen , Madden Sloan 
Published: September 2023

Abstract
Background
Exploration of client identity negotiations during treatment for Anorexia Nervosa (AN) is a relatively new area of research. Research suggests that difficulties with identity negotiations may present as a barrier to treatment. This study sought to explore individuals’ identity negotiations during therapy sessions using Compulsive Exercise Activity Therapy (LEAP) combined with Cognitive Behaviour Therapy for Anorexia Nervosa (CBT-AN). Analysis focused on moments in therapy where individuals’ identities were dominated or defined by AN and where alternative identities could be generated.
Method
40 in-session transcripts from sessions at early, mid and end points of the CBT-AN (with LEAP) treatment were qualitatively analysed for nine of the 78 participants in the original randomised control trial. Through a constructivist framework, thematic analysis was used to identify surface and latent meanings and discursive material participants used to negotiate their identities in the context of therapy sessions.
Results
Analysis of in-therapy transcripts generated two themes pertaining to identity negotiations: (1) AN identities and personal agency, and (2) building life and identities outside of the AN identity. Early therapy sessions explored fragmented and AN identities, including how AN was troubling to participants’ sense of self, contributed to conflicted identities, positioned them outside of normality, and was associated with isolated identities. Within therapy sessions, participants engaged in a recursive process of shifting relationships with themselves and building identities and lives outside of the AN identity. This included generating hopes for recovery and the future more frequently in mid- to late- therapy sessions.
Conclusion
Identity negotiations evident in the therapeutic conversations aligned with the key components of the CBT-AN intervention, including addressing (1) the characterisation of oneself as ‘an anorexic’ and (2) the diversification of roles and activities to broaden and enhance self-concepts. Future developments of therapeutic interventions for AN would benefit from greater consideration of ways to assist individuals to more comprehensively address problematic identities, including uncovering identities hidden by the AN identity and generating preferred identities.
Trial Registration:
Ethics approval was obtained at the time of the initial study and for this embedded research by the HREC at the Western Sydney University (HR777332).
Electrochemical sensor based on gum Arabic nanoparticles for rapid and in-situ detection of different heavy metals in real samples
Authors: Elamin Manahil Babiker , Chrouda Amani , Ali Shazalia Mahmoud Ahmed , Alhaidari Laila M. , Jabli Mahjoub , Elrouqi Rahaf , Renault Nicole Jafferezic 
Published: September 2023

Abstract
The key solution to combat trace metal pollution and keep the environment, ecosystem, animals, and humans safe is earlier and rapid trace metal detection. For all these reasons, we propose in this work the design of a simple electrochemical sensor functionalized with green nanoparticles for electrochemical detection of the fourth most dangerous heavy metal ions namely copper, zinc, lead, and mercury. The green nanoparticles are fabricated by a one-step, consisting of reducing platinum nanoparticles by a natural gum Arabic polymer. To guarantee the success of these nanoparticles' design, the nanoparticles have been characterized by Fourier-transform infrared spectroscopy FTIR, and thermogravimetric TGA techniques. While, for the electrochemical characterization, we have adopted cyclic voltammetry CV and electrochemical impedance spectroscopy EIS to control different steps of surface modification, and the differential pulse anodic stripping DPAS was monitored to follow up the electrochemical detection of different heavy metals.
Results have confirmed the good chemical and physical properties of the elaborated nanoparticles. As, the developed sensor showed a specific electrochemical response toward the heavy metal ions separately, with a lower limit of detection lower LOD than that recommended by the World Health Organization, in order of 9.6 ppb for Cu2+, 1.9 ppb for Zn2+, 0.9 ppb for Hg2+, and 4.2 ppb for Pb2+. Impressively, the elaborated sensor has demonstrated also high stability, outstanding sensitivity, and excellent analytical performance.
In addition, the elaborated analytical tool has been successfully applied to the determination of various heavy metal ions in real samples, reflecting then its promising prospect in practical application.
RETRACTED: Co-delivery of temozolomide and quercetin using folic acid- conjugated engineered exosomes for glioblastoma treatment: the in-vitro and in-vivo study
Authors: Pourmasoumi Parvin , Abdouss Majid , Farhadi Mona , Jameie Seyed Behnamedin , Khonakdar Hossein Ali 
Published: September 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
New approach of creation and modifying the characteristics of AgNPs/MWCNT/PSi hybrid structures
Authors: Ali Samah G. , Alwan Alwan M. , Jabbar Allaa A. 
Published: September 2023

Abstract
In this paper presents a new approach in modifying the properties of hybrid structures of silver nanoparticles (AgNPs) and multi wall carbon nanotubes (MWCNT); deposited on morphologically controlled porous silicon (PSi) surface. The PSi layer was prepared by Photo-electrochemical etching technique using a current density between 15 to 30mA/cm2. The AgNPs/ MWCNT was decorated on a PSi surface by a simple ion reduction from aqueous solutions of silver salt (AgNO3) at 5X10−2 M, 10− 2 M, 10− 3 M, and 10− 4 M concentrations. Structural, morphological and optical characterizations of (AgNPs/MWCNT/PSi) hybrid structure were analyzed with respect of the PSi layer morphology. The obtained results showed that a possibility of effectively controlling the hybrid structures morphology, the AgNPs size and the surface area by controlling the pores’ diameters. The deposition of the MWCNT and AgNPs on the wall and pore may enhance the specific surface area of the hybrid structure. Moreover, the decrease in the concentration of the silver salt aqueous solution can led to a significant decrease in the AgNPs sizes, and this can added another means in modifying the hybrid structures.