bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and evaluation study of FLY-Kids: a new lifestyle screening tool for young children
Authors: Krijger Anne , Schiphof-Godart Lieke , Elstgeest Liset , van Rossum Caroline , Verkaik-Kloosterman Janneke , Steenbergen Elly , ter Borg Sovianne , Lanting Caren , van Drongelen Karen , Engelse Ondine , Kindermann Angelika , Detmar Symone , Frenkel Carolien , Raat Hein , Joosten Koen 
Published: August 2023

AbstractEvaluating, discussing, and advising on young children’s lifestyles may contribute to timely modification of unhealthy behaviour and prevention of adverse health consequences. We aimed to develop and evaluate a new lifestyle screening tool for children aged 1–3 years. The lifestyle screening tool “FLY-Kids” was developed using data from lifestyle behaviour patterns of Dutch toddlers, age-specific lifestyle recommendations, target group analyses, and a Delphi process. Through 10 items, FLY-Kids generates a dashboard with an overview of the child’s lifestyle that can be used as conversation aid. FLY-Kids was completed by parents of children aged 1–3 years attending a regular youth healthcare appointment. Youth healthcare professionals (YHCP) then used the FLY-Kids dashboard to discuss lifestyle with the parents and provided tailored advice. Parents as well as YHCP evaluated the tool after use. Descriptive and correlation statistics were used to determine the usability, feasibility, and preliminary effect of FLY-Kids. Parents (N = 201) scored an average of 3.2 (out of 9, SD 1.6) unfavourable lifestyle behaviours in their children, while 3.0% complied with all recommendations. Most unfavourable behaviours were reported in unhealthy food intake and electronic screen time behaviour. Parents and YHCP regarded FLY-Kids as usable and feasible. The number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment (r = 0.47, p < 0.001). Conclusion: FLY-Kids can be used to identify unhealthy lifestyle behaviour in young children and guide the conversation about lifestyle in preventive healthcare settings. End-users rated FLY-Kids as helpful and user-friendly.

What is Known:• A healthy lifestyle is important for optimal growth, development and overall health of young children (1-3 years).• Evaluating, discussing and advising on young children’s lifestyles may contribute to timely modification of unhealthy behaviour and prevention of adverse health consequences.

What is New:• The new lifestyle screening tool FLY-Kids generates a dashboard with an overview of young children’s lifestyle that can be used as conversation aid between parents and youth healthcare professionals.• As parents and youth healthcare professionals rated FLY-Kids as helpful and user-friendly, and the number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment, FLY-Kids can be considered guiding the lifestyle discussion in preventive healthcare settings.
Protective effect of cryotherapy against oral mucositis among allogeneic hematopoietic stem cell transplant recipients using melphalan-based conditioning
Authors: Oku Saori , Futatsuki Toshiko , Imamura Yoshiko , Hikita Haruna , Inada Akemi , Mizutani Shinsuke , Mori Yasuo , Kashiwazaki Haruhiko 
Published: August 2023

Abstract
Purpose
Oral cryotherapy is an effective method to prevent oral mucositis (OM) induced by chemotherapeutic agents, such as melphalan (Mel). However, there is limited data about cryotherapy in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients; thus, the current study aimed to examine the efficacy of cryotherapy among allo-HSCT recipients treated with Mel-containing regimens.

Methods
Medical records of 78 consecutive allo-HSCT recipients were retrospectively analyzed. Baseline characteristics and clinical courses between the patients who received cryotherapy (cryotherapy group, n = 42) and those who did not (control group, n = 36) were compared, especially focusing on methotrexate (MTX) use as a part of graft-versus-host disease (GVHD) prophylaxis.

Results
Binary logistic regression analysis revealed that a higher dose of Mel (OR, 3.82; 95%CI, 1.085–13.46; P = 0.037) or MTX use (OR, 7.61; 95% CI, 2.41–23.97; P < 0.001) was associated with the incidence of OM. MTX use was also significantly associated with the duration of OM (β = 0.515; 95% CI, 9.712–21.636; P < 0.001). Among 31 patients without MTX use, cryotherapy was associated with a significant reduction of OM development (0% in the cryotherapy group vs 35% in the control group, P = 0.021). We did not find such an association in 47 patients with MTX use.

Conclusion
Cryotherapy was useful to prevent the incidence of OM in allo-HSCT recipients in the cases without MTX for GVHD prophylaxis.
Professionalisierung in der Psychoonkologie – die Bedeutung der Fort- und Weiterbildung
Authors: Weis J. , Blettner G. , Lehmann-Laue A. , Ihrig A. , von Saalfeld S. 
Published: August 2023

ZusammenfassungTrotz großer internationaler Unterschiede hat sich das Arbeitsgebiet Psychoonkologie innerhalb der letzten vier Jahrzehnte weltweit sowohl als wissenschaftliche Disziplin als auch als wichtiger Teil der onkologischen Versorgung etabliert. Um einheitliche Qualitätsstandards in der Versorgung umsetzen zu können, ist die professionelle Fort- und Weiterbildung mit einheitlichen Qualifizierungsstandards eine zentrale Aufgabe, um die Psychoonkologie als Tätigkeitsfeld für Berufsabsolvent*innen attraktiv machen zu können. Der vorliegende Überblicksartikel zeigt die Entwicklung und den aktuellen Stand der psychoonkologischen Fort- und Weiterbildung im internationalen Vergleich. Am Beispiel der Fort- und Weiterbildung für Psychosoziale Onkologie (WPO e. V.) wird die Entwicklung in Deutschland reflektiert. Schließlich werden die zukünftigen Aufgaben zur Stärkung der Professionalisierung in der Psychoonkologie aufgezeigt.
Factors influencing the acceptance of the measures for the containment of Covid-19
Authors: Kaltenhäuser Bernd 
Published: August 2023

Abstract
Aim
This study examines the impact of individual factors and personal experiences with Covid-19 on how one views the pandemic and the measures against it.

Subject and methods
For this, a survey was conducted and evaluated using structural equation modeling and multivariate statistics.

Results
Hereby, a higher approval was found for measures associated with a high contribution to the confinement of the pandemic but with low restrictions on the people at the same time. Furthermore, the results showed that people rating the pandemic as dangerous show a higher agreement with all measures, and likewise, these people decreasingly rate the measures as worse than the pandemic itself. Also, it could be shown that, especially personal experiences like a quarantaine and personal restrictions, increased the opinion that Covid-19 is a dangerous disease. Also, people informing themselves with alternative press rated Covid-19 as less dangerous. In contrast, age and gender had no influence on the view on the pandemic and the measures against it.

Conclusion
From the results, mainly two conclusions can be drawn: people can disinguish well between the benefits of single measures and personal experiences play an important role in their rating. Thus, when establishing measures in further pandemics, it might be wise to include the public’s opinion in all decisions.
Drag Assessment for Boundary Layer Control Schemes with Mass Injection
Authors: Fahland Georg , Atzori Marco , Frede Annika , Stroh Alexander , Frohnapfel Bettina , Gatti Davide 
Published: August 2023

AbstractThe present study considers uniform blowing in turbulent boundary layers as active flow control scheme for drag reduction on airfoils. The focus lies on the important question of how to quantify the drag reduction potential of this control scheme correctly. It is demonstrated that mass injection causes the body drag (the drag resulting from the stresses on the body) to differ from the wake survey drag (the momentum deficit in the wake of an airfoil), which is classically used in experiments as a surrogate for the former. This difference is related to the boundary layer control (BLC) penalty, an unavoidable drag portion which reflects the effort of a mass-injecting boundary layer control scheme. This is independent of how the control is implemented. With an integral momentum budget, we show that for the present control scheme, the wake survey drag contains the BLC penalty and is thus a measure for the inclusive drag of the airfoil, i.e. the one required to determine net drag reduction. The concept of the inclusive drag is extended also to boundary layers using the von Kàrmàn equation. This means that with mass injection the friction drag only is not sufficient to assess drag reduction also in canonical flows. Large Eddy Simulations and Reynolds-averaged Navier–Stokes simulations of the flow around airfoils are utilized to demonstrate the significance of this distinction for the scheme of uniform blowing. When the inclusive drag is properly accounted for, control scenarios previously considered to yield drag reduction actually show drag increase.
Litigation and settlement under loss aversion
Authors: Argenton Cédric , Wang Xiaoyu 
Published: August 2023

AbstractIn this paper, we investigate how loss aversion affects people’s behavior in private litigation. We find that a loss-averse plaintiff demands a higher settlement for intermediate claims to maintain her threat to proceed to trial following rejection compared to a loss-neutral plaintiff. For larger claims, a loss-averse plaintiff demands a lower offer to increase the settlement probability as loss pains her extra in trial. We also investigate how various policies affect loss-averse litigants’ settlement decisions. Only a reduction in the asymmetry of information about trial odds uniformly leads to higher settlement rates.
“How in God’s Name Are We Going to Navigate This?”: Parent Support for Transgender Adolescents
Authors: Dunlap Shannon L. , Goldbach Jeremy T. , Olson-Kennedy Johanna , Held Jordan 
Published: August 2023

AbstractThe extant literature has clearly demonstrated that transgender and nonbinary adolescents (TNBA) face extreme stress related to navigating gender identity and expression across various social environments. Additionally, parents are perhaps the most critical aspect of support for TNBA, and research has repeatedly identified the benefits of parent support for adolescent mental health. However, few studies underscore how TNBA and parents within the same family perceive parent support after adolescents disclose that they are transgender or nonbinary. The present qualitative study uses a life history calendar (LHC) interview approach with 20 TNBA-parent dyads (40 individual interviews) to explore TNBA-parent perceptions of parent support and adjustment related to TNBA gender identity and affirmation. Findings yielded three main points regarding parental support for TNBA. First, the time between disclosure to a parent and puberty mattered for parental support and adjustment processes. Second, parents who stepped into their child’s gender journey during their child’s adolescence grappled with feelings of grief and loss as they were making decisions to support their child’s gender affirmation. For many of these families, stigma-related fears and adolescent distress impacted parent support for their child’s gender journey. Third, parents lacked a familiar and affirming roadmap in their own families and communities, and although parents connected with other parents of trans kids for support, for some, these supportive resources presented challenges. Continued research can further study the complex drivers of support and the potential impact of these support processes on adolescent and parental well-being.
A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity
Authors: Assing Kristian , Jørgensen Sofie E. , Sandgaard Katrine S. , De Keukeleere Kerstin , B.-Hansen Marie , Petersen Mikkel S. , Hartling Ulla B. , Vaal Thanis M. K.-de , Nielsen Christian , Jakobsen Marianne A. , Watt Eleanor , Adams Stuart , Hao Qin , Fagerberg Christina , Mogensen Trine H. 
Published: August 2023

AbstractGenetic variants in cell division cycle 42 (CDC42) can manifest with dysmorphic features, autoinflammation, hemophagocytic lymphohistiocytosis, and thrombocytopenia, whereas defective thymopoiesis is a rare disease manifestation. We report a novel CDC42 missense variant (c.46A > G, p.Lys16Glu) resulting in infection and HPV-driven carcinogenesis in the mosaic mother and impaired thymopoiesis and profound T cell lymphopenia in the heterozygous daughter identified through newborn screening for SCID. We found that surface expression of IL-7Rα (CD127) was decreased, consistent with reduced IL-7-induced STAT5 phosphorylation and accelerated apoptotic T cell death. Consistent with the vital role of IL-7 in regulating thymopoiesis, both patients displayed reduced T cell receptor CDR3 repertoires. Moreover, the CDC42 variant prevented binding to the downstream effector, p21-activated kinase (PAK)1, suggesting this impaired interaction to underlie reduced IL-7Rα expression and signaling. Here, we provide the first report of severely compromised thymopoiesis and perturbed IL-7Rα signaling caused by a novel CDC42 variant and presenting with diverging clinical and immunological phenotypes in patients.
A Lipid-Structured Model of Atherosclerotic Plaque Macrophages with Lipid-Dependent Kinetics
Authors: Watson Michael G. , Chambers Keith L. , Myerscough Mary R. 
Published: August 2023

AbstractAtherosclerotic plaques are fatty growths in artery walls that cause heart attacks and strokes. Plaque formation is driven by macrophages that are recruited to the artery wall. These cells consume and remove blood-derived lipids, such as modified low-density lipoprotein. Ineffective lipid removal, due to macrophage death and other factors, leads to the accumulation of lipid-loaded macrophages and formation of a necrotic lipid core. Experimental observations suggest that macrophage functionality varies with the extent of lipid loading. However, little is known about the influence of macrophage lipid loads on plaque fate. Extending work by Ford et al. (J Theor Biol 479:48–63, 2019) and Chambers et al. (A lipid-structured model of atherosclerosis with macrophage proliferation, 2022), we develop a plaque model where macrophages are structured by their ingested lipid load and behave in a lipid-dependent manner. The model considers several macrophage behaviours, including recruitment to and emigration from the artery wall; proliferation and apotosis; ingestion of plaque lipids; and secondary necrosis of apoptotic cells. We consider apoptosis, emigration and proliferation to be lipid-dependent and we model these effects using experimentally informed functions of the internalised lipid load. Our results demonstrate that lipid-dependent macrophage behaviour can substantially alter plaque fate by changing both the total quantity of lipid in the plaque and the distribution of lipid between the live cells, dead cells and necrotic core. The consequences of macrophage lipid-dependence are often unpredictable because lipid-dependent effects introduce subtle, nonlinear interactions between the modelled cell behaviours. These observations highlight the importance of mathematical modelling in unravelling the complexities of macrophage lipid accumulation during atherosclerotic plaque formation.
Equine induced pluripotent stem cells are responsive to inflammatory cytokines before and after differentiation into musculoskeletal cell types
Authors: Palomino Lago Esther , Jelbert Elizabeth R. , Baird Arabella , Lam Pak Y. , Guest Deborah J. 
Published: August 2023

AbstractPersistent inflammation is associated with the poor regeneration of musculoskeletal tissues. Embryonic stem cells (ESCs) have an attenuated response to inflammatory cytokines, but there are mixed reports on the response of induced pluripotent stem cells (iPSCs) to inflammation. Horses provide a relevant large animal model for studying musculoskeletal tissue diseases and the testing of novel therapies. The aim of this study was to determine if equine iPSCs are responsive to the inflammatory cytokines IL-1β, TNFα and IFN-γ in their undifferentiated state, or following differentiation into tendon and cartilage-like cells. We demonstrated that in undifferentiated iPSCs, the cytokines induce NF-κB P65 and STAT1 nuclear translocation which leads to cell death, decreased OCT4 expression and increased expression of inflammatory genes. Following differentiation towards cartilage-like cells exposure to the cytokines resulted in STAT1 nuclear translocation, changes in cartilage gene expression and increased expression of matrix metalloproteinases (MMPs) and inflammatory genes. Exposure of iPSC-derived tendon-like cells to the cytokines resulted nuclear translocation of NF-κB P65 and STAT1, altered tendon gene expression, increased MMP expression and increased expression of inflammatory genes. Equine iPSCs are therefore capable of responding to inflammatory stimulation and this may have relevance for their future clinical application.
Methodologische Empfehlungen zur Neurowissenschaft des luziden Träumens
Authors: Adelhöfer Nico 
Published: August 2023

ZusammenfassungDas luzide Träumen ist ein einzigartiges Phänomen, bei dem sich eine Person während des Schlafs bewusst ist, dass sie träumt, und dadurch häufig ihre Handlungen während des Traums bewusst steuern kann. Dieser Artikel beleuchtet kritisch die methodischen Herausforderungen bei der Erforschung des luziden Träumens und bietet Strategien zu deren Bewältigung unter Berücksichtigung neuer theoretischer und empirischer Erkenntnisse. Methodische Strenge ist für den Fortschritt auf diesem Gebiet unerlässlich. Zu den Schlüsselbereichen, auf die man sich konzentrieren sollte, gehören standardisierte EEG-Vorverarbeitungen, die Berücksichtigung von nächtlichen Störfaktoren und die Untersuchung von nichtoszillatorischen Signalaspekten wie neuronalem Rauschen. Die Verwendung von Datenanalysen auf Quellenebene könnte neue neurophysiologische Marker für luzides Träumen aufdecken und so zu einem umfassenderen Verständnis des Phänomens führen. Der Artikel enthält auch Hinweise, wie sichergestellt werden kann, dass neu erhobene Daten über luzides Träumen für die vorgeschlagenen methodischen Verbesserungen geeignet sind. Obwohl der Ton dieses Artikels kritisch ist, hebt er das Potenzial hervor, das die Forschung zum luziden Träumen hat, wenn diese Herausforderungen richtig angegangen werden. Die Überwindung der hier beschriebenen Einschränkungen wird es den Forschenden ermöglichen, das breite Spektrum der Möglichkeiten, die das luzide Träumen bietet, voll auszuschöpfen – von der Erweiterung unseres Wissens über das Bewusstsein bis hin zu neuen therapeutischen Anwendungen. Indem wir unsere Methoden verfeinern und diese Probleme angehen, kann das Forschungsfeld des luziden Träumens weiter wachsen und sich entwickeln und schließlich sein volles Potenzial entfalten.
Dermoscopy-assisted prevalence of hair loss after COVID-19 vaccination among an Egyptian population: a cross-sectional study
Authors: Ammar Amr M. , Ibrahim Ibrahim S. , Mohamed Abbas N. , Elsaie Mohamed L. 
Published: August 2023

Abstact
Background
Coronavirus disease (COVID-19) currently named SARS-CoV-2 is a contagious disease caused by a coronavirus; incompatible data are present on the possible relationship among COVID-19 vaccines and hair loss.

Aims
The objective of the current study was to assess dermoscopically the prevalence of hair loss among an Egyptian population following COVID-19 vaccination.

Methods
A total of 2000 participants were enrolled in this cross-sectional study. Adult males and females who received one of recognized COVID-19 vaccine were included, irrespective of the status of previous COVID-19 infection. Those who were aged less than 18 years or above 60 years were excluded. Furthermore, subjects self-reporting hair loss were assessed by dermoscopy.

Results
Among the studied cases, n = 478 (23.9%) complained of hair loss following vaccination. The majority of cases noticed their hair loss during the first 2 months post-vaccination (n = 215 after the first month and n = 158 after the 2nd month respectively).

Conclusion
We reported prevalence of post-vaccination hair fall that was confirmed by trichoscopy and which affected approximately one quarter of participants who received COVID-19 vaccines. Other factors, such as stress and infection, cannot be excluded and remain to be further investigated by larger multicenter studies.
Comparison of the outcomes between total arch replacement and nontotal arch replacement in patients with acute type A aortic dissection
Authors: Lerdpunnapongse Pichej , Slisatkorn Worawong , Wongkornrat Wanchai , Sanphasitvong Vutthipong 
Published: August 2023

Abstract
Objective
To compare the outcomes between total arch replacement (TAR) and nontotal arch replacement (non-TAR) in patients with acute type A aortic dissection (ATAAD).

Methods
Between 2006 and 2018, 275 ATAAD patients were divided into 2 groups, the TAR group (n = 63) and the non-TAR group (n = 212), and multiple variables were analyzed.

Results
The TAR patients were older than the non-TAR patients (61.5 ± 11.8 vs. 57.4 ± 14.5 years, p = 0.024). The TAR group had longer operative, cardiopulmonary bypass, aortic clamping, and circulatory arrest times than the non-TAR group (all p < 0.001). The overall hospital mortality rate was 8.7% with no statistically significant difference between the TAR and non-TAR groups (9.5% vs. 8.5%, p = 0.799). There was no significant difference in the incidence of acute kidney injury (AKI), intubation time, incidence of postoperative atrial fibrillation (AF), or reoperation for bleeding or reintervention rates between the TAR and non-TAR groups (68.3% vs. 65.7% (p = 0.912), 44.8% vs. 33.8% (p = 0.127), 30.2% vs. 22.6% (p = 0.222), 9.5% vs. 9.5% (p = 0.189), and 7.9% vs. 7.1% (p = 0.077), respectively). The TAR group had a higher rate of new permanent neurological deficit (PND) than the non-TAR group and longer median length of hospital stay (17.5% vs. 6.1% (p < 0.001) and 9 vs. 12 days (p = 0.049), respectively). TAR (relative risk (RR) 3.66, p = 0.005) and preoperative cardiopulmonary resuscitation (CPR) (RR 6.60, p = 0.019) were risk factors of PND. Survival rate was similar between the two groups.

Conclusion
The mortality rates in ATAAD patients with TAR and non-TAR were similar. However, the incidence of new permanent postoperative neurological deficit was significantly higher, and the length of hospital stay was longer in patients with TAR. TAR in ATAAD should be avoided especially in patients who have experienced preoperative CPR to abate risk of PND.
A lower bound for differential uniformity by multiplicative complexity & bijective functions of multiplicative complexity 1 over finite fields
Authors: Steiner Matthias Johann 
Published: August 2023

AbstractThe multiplicative complexity of an S-box over a finite field is the minimum number of multiplications needed to implement the S-box as an arithmetic circuit. In this paper we fully characterize bijective S-boxes with multiplicative complexity 1 up to affine equivalence over any finite field. We show that under affine equivalence in odd characteristic there are two classes of bijective functions and in even characteristic there are three classes of bijective functions with multiplicative complexity 1. Moreover, in (Jeon et al., Cryptogr. Commun., 14(4), 849-874 (2022)) A-boxes where introduced to lower bound the differential uniformity of an S-box over $$\mathbb {F}_{2}^{n}$$

F

2

n

via its multiplicative complexity. We generalize this concept to arbitrary finite fields. In particular, we show that the differential uniformity of a (n, m)-S-box over $$\mathbb {F}_{q}$$

F
q

is at least $$q^{n - l}$$

q

n
-
l

, where $$\lfloor \frac{n - 1}{2} \rfloor + l$$

⌊

n
-
1

2

⌋
+
l

is the multiplicative complexity of the S-box.