bluuebunny/crossref_metadata_2025_split huggingface dataset:
Male Mortality from Sensitive Conditions to Primary Care from the Brazilian National Men’s Health Policy’s Perspective
Authors: de Paula Cácia Régia , Pelazza Bruno Bordin , de Lima Flavio Henrique Alves , Maia Ludmila Grego , de Araújo Reila Campos Guimarães , Tacsi Yolanda Rufina Condorimay , Ferri Lucila Pesuti , Meireles Gláucia Oliveira Abreu Batista , Ferreira Pedro Lopes , Sousa Ana Luiza Lima , Matos Marcos André , Barbosa Maria Alves 
Published: December 2022

Abstract
To assess male mortality trend and its relationship with conditions sensitive to primary care (CSPC), considering Family Health Strategy (FHS) coverage and Brazilian National Policy for Comprehensive Men’s Health Care (PNAISH) implementation. This is an ecological time series study of male deaths, aged 20 to 59 years, according to CSPC, from 2009 to 2018. The relationship between CSPC mortality and FHS coverage was quantified by Spearman’s correlation. The trend in the number of deaths was adjusted by univariate Quasi-Poisson Regression models. CSPC accounted for 1,092,070 (19.2%) deaths in the municipalities, with an annual variation from − 4.89–3.06% and did not show a significant relationship with mean FHS coverage (r < 0.09; p < 0.160). FHS coverage showed a significant upward trend [95% CI; 1.03–1.09]. The trend of deaths in the study groups due to CSPC was generally stable (Exp (β) = 1.01; p > 0.593). FHS coverage expansion and the fact that PNAISH was implemented in all municipalities in the state of Goiás did not influence death rates due to CSPC in general.
Dietary guanidine acetic acid addition improved carcass quality with less back-fat thickness and remarkably increased meat protein deposition in rapid-growing lambs fed different forage types
Authors: Li Wen-Juan , Jiang Yao-Wen , Cui Zhao-Yang , Wu Qi-Chao , Zhang Fan , Chen He-Wei , Wang Yan-Lu , Wang Wei-Kang , Lv Liang-Kang , Xiong Feng-Liang , Liu Ying-Yi , aisikaer ailiyasi , Li Sheng-li , Bo Yu-Kun , Yang Hongjian 
Published: December 2022

Abstract
Background: The aim of this study was to investigate whether guanidine acetic acid (GAA) yields a response inrapid-growing lambs depending on forage type. In this study, seventy-two small tailed Han lambs (two months old; initial body weights = 12 ± 1.6 kg) were used in a 120-d feeding experiment after a 7-d adaptation period. A 2 × 3 factorial experimental feeding design was applied to the lambs, which were fed total mixed ration with two forage types (OH: oaten hay; OHWS: oaten hay plus wheat silage) and three forms of additional GAA (GAA: 0 g/kg; UGAA: Uncoated GAA, 1 g/kg; CGAA: Coated GAA, 1 g/kg).
Results: The OH diet had greater dry matter intake, average daily gain, and hot carcass weight than OHWS diet. The GAA supplementation increased final body weight, hot carcass weight, dressing percentage, and ribeye area in longissimus lumborum. Meanwhile, decreased backfat thickness and serum triglycerides in GAA fed lambs may through increasing hormone sensitive triglyceride lipase (HSL). Dietary GAA decreased the pH value, elevated the water-holding capacity (by reducing drip loss and cooking loss) in mutton. In addition, the crude protein content in mutton increased with GAA addition may through regulation with PIK3C3 /Akt1/mTOR signaling pathway.
Conclusions: Dietary GAA (UGAA or CGAA) might be an effective additive in lamb fed different forage types, as it has potential to improve growth performance and meat quality.
Optimizing the risk stratification of astrocytic tumors by applying the cIMPACT- NOW Update 3 signature: real-word single center experience
Authors: Molica Carmen , Pierini Tiziana , Gili Alessio , Nardelli Carlotta , Arniani Silvia , Mavridou Elena , Gorello Paolo , Corinaldesi Rodolfo , Metro Giulio , Giovenali Paolo , Castrioto Corrado , Lupattelli Marco , Roila Fausto , Mecucci Cristina , Starza Roberta La 
Published: December 2022

AbstractPurpose. Implementation of a useful genetic diagnosis for the clinical management of patients with astrocytic tumors.Methods. We investigated 314 prospectively recruited diffuse astrocytic tumours by applying the cIMPACT-NOW Update 3 signature.Results. The cIMPACT-NOW Update 3 (cIMPACT 3+) markers, i.e. alterations of TERT promoter, EGFR, and/or chromosome 7 and 10, characterized 98.5% of IDH-wt cases. Interestingly, it was also found in 57.5% of IDH-mut cases. According to the genomic profile, four genetic subgroups could be distinguished: 1) IDH-wt/cIMPACT 3-negative (=4); 2) IDH-mut/cIMPACT 3-negative (n=14); 3) IDH-mut/cIMPACT 3+ (n=20); and 4) IDH-wt/cIMPACT 3+ (n=276). Multivariate analysis confirmed that IDH1/2 mutations confer a favorable prognosis (IDH-wt, HR 2.91 95%, CI 1.40-6.05), and validated the prognostic value of the cIMPACT 3+ signature.Conclusions. To accurately identify relevant prognostic categories, overcoming the limitations of histopathology and immunohistochemistry, molecular-cytogenetic analyses must be fully integrated into the diagnostic work-up of astrocytic tumors.
Phosphocreatine protects against diabetic retinopathy via improving mitochondrial functions bioenergetics through JAK2/STAT3 signaling pathway in Vivo and in Vitro
Authors: Qaed Eskandar , Zaky Mohamed Y. , Chu Peng , Yafei Saeed , Belal Amany , Abourehab Mohammed A.S. , Almoiliqy Marwan , Li Hailong , Al-Maamari Ahmed , Sultan Marwa , Wang Fu Han , Fang Jia Ni , Tang Zeyao , Sun Zhaolin 
Published: December 2022

Abstract
The most prevalent chronic consequence of diabetes mellitus is diabetic retinopathy (DR), a clinically microvascular disease characterized by damage to retinal capillaries with subsequent visual deterioration or blindness. DR is mainly attributed to hyperglycemia-induced retinal microvascular damage, however, emerging research has demonstrated that it is intimately linked to mitochondrial energy shortage and raises the generation of reactive emerging research has demonstrated that it is intimately linked to mitochondrial energy shortage and raises the generation of reactive oxygen species (ROS). This study is aimed to develop and investigate methods to safeguard DR membrane composition, such as regaining methods to safeguard DR membrane composition, such as regaining mitochondrial function. Controlling for hyperglycemia cannot reverse the pathologic changes induced by diabetes in the retinal mitochondria. In mitochondria damaged by hyperglycemia, we proposed that phosphocreatine (PCr) might enhance oxidative phosphorylation and electron transport capability. Similarly, we anticipated estimating PCr's protection against DR via the JAK2/STAT3 signaling pathway. PCr has a crucial metabolic function in DR cells, which includes controlling the intracellular content of ATP. Rat mitochondria and RGC-5 cells were evaluated for capacity using high-resolution respirometry (HRR). The expression of JAK2/STAT3 signaling pathways and apoptotic proteins were detected using western blotting. We assessed ROS production and mitochondrial membrane potential (MMP) in Wistar male rats with streptozotocin induced-diabetes. In this study, we found that PCr had protective effects against DR injury by boosting mitochondrial bioenergetics and preventing DR by easing the symptoms of diabetes and improving biochemical indicators. Additionally, PCr decreased the expression of Bax, cleaved caspase 3, cleaved caspase 9, as well as the JAK2/STAT3 signaling pathway while increasing the expression of Bcl-2, caspase 3, and caspase 9 proteins. In Conclusions when exposed to oxidative stress caused by hyperglycemia, PCr improves mitochondrial activity and has antiapoptotic effects in vivo and in vitro through the JAK2/STAT3 signaling pathway. These findings suggest that PCr is a potentially effective therapeutic approach for diabetic retinopathy.
A longitudinal study of sexual activity and influencing factors in breast cancer patients during treatment: a trajectory analysis model
Authors: ZHANG Tian , ZHANG Xiaolu , Yang Jing , Wen Min , Liao Jiaqian , Chen Shouli , Wang Yingyin , DENG Xiaoyuan , LIU Xiaoyan , WANG Guorong 
Published: December 2022

Abstract
Purpose: To describe the longitudinal track of sexual activity in patients with breast cancer during treatment and its influencing factors.
Methods: A prospective longitudinal study was conducted to investigate 225 patients who were first diagnosed with breast cancer in A tumor specialty three-class hospital in Southwest China. 225 patients were evaluated for sexual activity at the time of admission and diagnosis (T0) and one month (T1), three months (T2), six months (T3), and nine months (T4) after diagnosis.
A trajectory analysis model (GBTM) was used to explore the changes in sexual activity in breast cancer patients. Logistic regression analysis was used to analyse the factors that affected the classification of sexual activity trajectories.
Results: The ratio of sexual activity abruptly declined from 100% at baseline to 39.1% at T1. The percentage of sexual activity was improved, from 51.4% at T2 to 63.1% at T4. The optimal model was a 2-group trajectory of sexual activity in breast cancer patients,36.6% in the "low activity group" and 63.4% in the "high activity group." The factors influencing the grouping of sexual activity trajectories were aging (β=0.751, P=0.004), sexual desire at baseline (β=0.724, P=0.003), and vaginal lubrication (β=1.177, P<0.001).
Conclusions: Research has demonstrated that the sexual activity level of breast cancer patients decreases in early stage and increases over time. Moreover, we observed that breast cancer patients had better libido and vaginal lubrication before the disease, especially those older than 50. At the same time, we suggest that the level of sexual activity in young breast cancer patients is a tremendous worthy concern during clinical work. Efficient interventions of sexual activity in advance of treatment may help to improve the sexual health of these patient populations.
Implications for cancer survivors：There is a need to re-examine the evaluation steps of sexual function in breast cancer patients and provide targeted intervention services for patients.
Molecular Structure of 2-hydroxy-5-methyl-2-nitroazobenzene Isomer: DFT Insight
Authors: Nainggolan Fernando 
Published: December 2022

Abstract
It is currently thought that azobenzene molecules exist in trans and cis form of molecular structure configuration. Affirmation supporting this perspective has been substantially derived by theoretical results in the isomerization process. However, whether these molecular structures may affect the electronic properties entirely need to be confirmed. In this study, I give my effort to understand the molecular structure properties of trans and cis form of azobenzene molecule from 2-hydroxy-5-methyl-2’-nitroazobenzene (HMNA). Their chemistry phenomena are investigated using density functional theory (DFT) method. According to this study, it show that the molecular size of trans form of HMNA is 9.0 Å and cis form of HMNA is 6.6 Å, have electronic transition of π → π* type driven by azo bond in trans-HMNA whereas C = C bond on the benzene ring offers higher contribution for cis-HMNA and also cis-HMNA shows n → π* type with respect to the non-bonding electrons of oxygen and nitrogen atoms while trans-HMNA form does not show any significance. Therefore, this molecule system as a push-pull molecule system contributes to the chemistry properties and phenomenon for molecular structure, electronic transition and mechanism pathway of trans to cis isomer formation in the ground state.
WITHDRAWN: DSBAL: Distributed Stacked Bidirectional Attention-based LSTM Method for Time Series Forecasting
Authors: Prakash N. , G Sumaiya Farzana. 
Published: December 2022

Abstract
Accurate time series forecasting is crucial to increase the performance and turnover of every business. However, It’s quite a difficult task due to the non-stationary and high level of uncertainty in the time series data. This paper proposes a new method called the Distributed Stacked Bidirectional Attention Long Short-Term Memory Neural Network (DSBAL) for time series forecasting. The DSBAL method combines the Stacked Bidirectional LSTM (SBiLSTM) and Attention mechanism in distributed computing. The proposed method consists of an SBiLSTM encoder, attention mechanism, and SBiLSTM decoder. SBiLSTM encoder is used to extract the complex features in the daily tomato supply data, in addition, the Attention mechanism is introduced to enhance the performance of SBILSTM by selecting the more appropriate sequence in the data by giving higher weightage to them. SBiLSTM decoder uses the most appropriate sequences from the attention mechanism to predict the daily tomato supply data. The entire process of the proposed method runs in distributed computing to improve efficiency, accuracy, and scalability. Our proposed method allows us to use only appropriate sequences in the data, captures complicated patterns, and addresses computational issues. To prove the efficiency of the proposed methodology, the experiments are conducted with other time series forecasting methods like RNN, LSTM, Stacked LSTM, Bidirectional LSTM, and Attention LSTM using daily tomato supply datasets in terms of SMAPE and RMSE. The results obtained from the experiment demonstrate that our proposed method is more efficient, accurate, and scalable.
WITHDRAWN: KNOWLEDGE AND OPINIONS OF TURKISH UNIVERSITY STUDENTS REGARDING THE USE OF CONTRACEPTIVE METHODS: A QUALITATIVE STUDY
Authors: PAŞA Büşra KÜÇÜKTÜRKMEN , TARUS Hamide ARSLAN , SUVEREN Yaşar , TURAN Zekiye 
Published: December 2022

Abstract
Aim: This study aimed to identify the knowledge and views of university students regarding the use of contraceptive methods.
Materials and Methods: The study, in which a qualitative research method was applied, was conducted with 38 students studying at a university in the Marmara Region of Türkiye. Data were collected via semi-structured interviews and participant information forms and were evaluated using the content analysis technique.
Results:Based on the interviews with the students, four main themes were determined: “Personal opinions on the use of contraceptive methods,” “Opinions on social perspectives on the use of contraceptive methods,” “Knowledge and awareness about contraceptive methods,” and “Suggestions and expectations for contraceptive methods.”
Conclusion: Although these university students were ill-informed about contraception, they held positive views on the use of contraceptive methods and they disagreed with the prevailing societal views. The organization of educational programs to increase young people’s knowledge of contraceptive methods may contribute to the protection and improvement of sexual and reproductive health.
Non-autoimmune overt hypothyroidism in the early stages of nephrotic syndrome: A case report from Somalia
Authors: Siyad Mohamed Osman , Adan Abdisamad Mohamed , Jeele Mohamed Osman Omar 
Published: December 2022

Abstract
Nephrotic syndrome (NS) was first characterized in 1827 as the occurrence of proteinuria greater than or equal to 3.5 g/24 hours, hypoalbuminemia (albumin less than or equal to 3.0 g/dl), peripheral edema, hyperlipidemia, lipiduria caused by increased permeability of the renal glomerulus. In the early stage of NS the loss of thyroid hormones rarely leads to hypothyroidism and euthyroid state is expected. However, persistent proteinuria will eventually lead to hypothyroidism. Non-autoimmune hypothyroidism due to NS which presents at an early stage of NS is quite rare and cases reporting it are very scarce in the literature. In the presenting case, we reported a 26-year-old male patient with no known history of chronic disease who presented to the emergency department with a complaint of one-week generalized edema, nausea, fatigue, and generalized ache in the extremities. He was diagnosed with nephrotic syndrome complicated by hypothyroidism and was hospitalized for 3 weeks. After 3 weeks of treatment and close monitoring, the patient’s clinical condition and laboratory investigations were improved and was discharged in good health.
Molecular Dynamics Simulation of Atomic Interaction between Main Protein of Human Prostate Cancer and Fe/C720 Buckyballs-Statin Structures
Authors: Panah Mohammad Pour , Sabetvand Roozbeh 
Published: December 2022

Abstract
Background and Objective
Atomic interaction between main protein of Human Prostate Cancer (PHPC) and Fe/C720 Buckyballs-Statin is important for medical science. For the first time, we use Molecular dynamics (MD) approach based on Newton's formalism to describe the destruction of HPC via Fe/C720 Buckyballs-Statin with atomic accuracy.
Methods
In this work, the atomic interaction of PHPC and Fe/C720 Buckyballs-Statin introduced via equilibrium molecular dynamics approach. In this method, each PHPC and Fe/C720 Buckyballs-Statin is defined by C, H, Cl, N, O, P, S, and Fe elements and contrived by Universal Force Field (UFF) and DREIDING force-field to introduce their time evolution.
Results
The results of our studies regarding the dynamical behavior of these atom-base compounds have been reported by calculating the Potential energy, center of mass (COM) position, diffusion ratio and volume of defined systems. The estimated values for these quantities show the attraction force between Buckyball-based structure and protein sample, which COM distance of these samples changes from 10.27. Å to 2.96. Å after 10 ns. Physically, this interactions causing the destruction of the PHPC. Numerically, the volume of this protein enlarged from 665276 Å3 to 737143 Å3 by MD time passing. This finding reported for the first time which can be considered by the pharmaceutical industry.
Conclusion
Volume of the PHPC increases by Fe/C720 Buckyballs-Statin diffusion into this compound. By enlarging this quantity (diffusion coefficient), the atomic stability of PHPC decreases and protein destruction procedure fulfilled.
Due to forgetting to take antihypertensive medication, a hypertensive emergency occurred: A Case Report and Discussion
Authors: Bereda Gudisa 
Published: December 2022

Abstract
A life-threatening condition known as a "hypertensive emergency" is marked by a severe increase in blood pressure together with acute or significant target organ damage. On June 1, 2022, a 67-year-old black male farmer was admitted to the emergency department with a major chief complaint of breathing difficulty. The patient was traveling to the village for work and forgetting his medication at home, and he was losing consciousness and motor activity at his workplace. He presented with symptoms of shortness of breath, confusion, dizziness, nausea, vomiting, blurred vision, and faintness. An abnormal cardiac region was visible on chest X-rays, and there were no changes to the pulmonary parenchyma or fluid overload. Upon admission, hydralazine (5 mg) intravenously was administered immediately, and he was reassessed after 20 minutes and kept at the emergency department. The next day, sustained-release nifedipine (20 mg) was initiated orally twice a day for the patient, and he was transferred to the medical ward. In the medical ward, the patient was assessed for four days, and in those four days, he showed marked improvement. Hypertensive emergency treatment intends to reverse target organ damage, readily lowering blood pressure, decreasing adverse clinical complications, and enhancing the quality of life.
Modeling the Omicron Dynamics and Development in China with a Deep Learning Enhanced Compartmental Model
Authors: Deng Qi , Wang Guifang 
Published: December 2022

Abstract
Background: The mainstream compartmental models require stochastic parameterization to estimate the transmission parameters between compartments, which depends upon detailed statistics on epidemiological transmission characteristics that are economically and resource-wide expensive to collect. As an alternative, deep learning techniques are effective in estimating these stochastic parameters with greatly reduced dependency on data particularity.
Methods: We apply deep learning to estimate transmission parameters of a customized compartmental model, then feed the estimated transmission parameters to the compartmental model to predict the development of the Omicron epidemics in China for 28 days.
Results: In China mainland, the daily Omicron infection increase is between 60 and 260 in the 28-day forecast period between June 4 and July 1, 2022. On July 1, 2022, there would be 768,622 cumulative confirmed cases and 591 cumulative deceased cases. The average levels of predication accuracy of the model are 98% and 92% for number of infections and deaths, respectively.
Conclusions: The effectiveness of prevalent compartmental modes depends upon detailed statistics on epidemiological transmission characteristics. As an alternative, deep learning techniques are effective in estimating these stochastic parameters with greatly reduced dependency on data particularity. Our model demonstrates the efficacy and potential of applying deep learning methodologies in predicting the dynamics of infectious diseases.
Knowledge Marketing: n(P, C, S, V)’s Mix?
Authors: Artyukhova Nadiia , Krmela Jan , Krmelova Vladimira , Ospanov Dastan 
Published: December 2022

Authors:
Nadiia Artyukhova, ORCID: https://orcid.org/0000-0002-2408-5737
PhD, Associated Professor, Sumy State University, Ukraine
Jan Krmela, ORCID: https://orcid.org/0000-0001-9767-9870
PhD, Associated Professor, University of Pardubice, Czech Republic
Vladimira Krmelova, ORCID: https://orcid.org/0000-0002-3822-3416
PhD, Associated Professor, Alexander Dubcek University of Trencin, Slovak Republic
Dastan Ospanov, ORCID: https://orcid.org/0000-0003-0401-180X
Saken Seifullin Kazakh Agrotechnical University, Kazakhstan

Pages: 182-189

Language: English

DOI: https://doi.org/10.21272/mmi.2022.3-16

Received: 02.06.2022

Accepted: 02.09.2022

Published: 30.09.2022

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Abstract

The work is devoted to the search for the optimal algorithm for implementing the process of promoting knowledge in the educational services market. The «product» of promotion is an educational program. Promotion of products of educational activities could be built along the general line «internal quality assurance of education – reviews of internal stakeholders – external quality assurance of education – reviews of external stakeholders – a business card of an educational product». When applied to an educational program as an object of knowledge marketing, a business card is a set of innovative features that could be used as the basis for implementing a particular strategy. In the frame of the work for describing the process of promoting the educational program abstract-logical method, the method of analogies, and the method of induction-deduction were used. A bibliometric analysis was carried out based on an array of bibliographic data of articles from the Scopus database using the VOSviewer tool to assess the possibility of combining different marketing mix models. The results of the bibliometric analysis show that the marketing mix model applies to the promotion of knowledge (educational program) as a product of the DIKW model. At the same time, the question of choosing a marketing mix strategy or justifying the need to combine these strategies remains open. As part of the work, a link was made between generating the knowledge model and promoting an educational program as a product of the DIKW model. Bibliometric analysis showed that using a single marketing mix strategy currently does not lead to success in product promotion. A combination of different strategy indicators is needed. At the same time, it is essential to establish the degree of significance of each indicator in the overall rating and to screen out (if necessary) individual indicators. A multi-level expert assessment determines the degree of significance of each indicator. Based on the results of this assessment, a specific set of indicators for this educational program and the dominant strategy, if any, are formed. A combined approach for promoting an educational program is developed based on an analysis of individual indicators and a multi-stage expert assessment of internal and external stakeholders.