bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can wrist-worn devices and a smartphone application influence arm activity in children with unilateral cerebral palsy? A proof-of-concept study
Authors: Turner Amie , Jackson Dan , Officer Eleanor , Boyne-Nelson Chelsy , Zielinska Zosia , Dinraj Divya , Blickwedel Jessica , Nappey Tom , Rapley Tim , Turpin Heather , Cadwgan Jill , Pearse Janice Elizabeth , Basu Anna Purna 
Published: January 2023

AimTo determine whether a wrist-worn triaxial accelerometer-based device and software (including smartphone application), incorporating feedback, is feasible, acceptable, and can lead to increased affected upper limb use during everyday activities in children with unilateral cerebral palsy (UCP).MethodsStudy design: Mixed methods proof of concept study. Participants: Children aged 8–18 years with UCP; age-matched typically developing controls (“Buddies”), therapists. Intervention:Baseline (2 weeks): devices recorded arm activity. Active feedback (6 weeks): devices also gave vibratory prompts if affected arm activity fell below pre-set personalised thresholds (UCP group only; control group continued as per Baseline). Final 2 weeks: as baseline. Both groups accessed a smartphone application providing feedback on relative arm motion throughout the study. Assessment and analysis: ABILHAND-Kids questionnaires and MACS classifications captured baseline participant characteristics (UCP group). Accelerometer data was used to calculate relative arm activity (signal vector magnitude) corrected for time worn/day, and trends in relative arm activity examined using single case experimental design (both groups). In-depth interviews with families, “Buddies” and therapists assessed feasibility and acceptability of implementation. A framework approach was used for qualitative data analysis.ResultsWe recruited 19 participants with UCP; 19 buddies; and 7 therapists. Five participants (two with UCP) did not complete the study. Baseline mean (stdev) ABILHAND-Kids score of children with UCP who completed the study was 65.7 (16.2); modal MACS score was II.Qualitative analysis demonstrated acceptability and feasibility of the approach. Active therapist input for this group was minimal. Therapists appreciated the potential for summary patient data to inform management. Arm activity in children with UCP increased in the hour following a prompt (mean effect size z = 0.261) for the non-dominant hand, and the dominant hand (z = 0.247). However, a significant increase in affected arm activity between baseline and intervention periods was not demonstrated.DiscussionChildren with UCP were prepared to wear the wristband devices for prolonged periods. Whilst arm activity increased bilaterally in the hour following a prompt, increases were not sustained. Delivery of the study during the COVID-19 pandemic may have negatively influenced findings. Technological challenges occurred but could be overcome. Future testing should incorporate structured therapy input.
Diversity and enzymatic activity of the microbiota isolated from compost based on restaurant waste and yard trimmings
Authors: da Silva Gaspar Suelen , Assis Lucas Lenin Resende de , Prado Maria Paula Ramos do , Pedroso Miguel Maria Gabriela , Magno dos Reis Ferreira Gustavo , Schwan Rosane Freitas , Pasqual Moacir , Rigobelo Everlon Cid , Castro Rafael Peron , Buttrós Victor Hugo , Dória Joyce 
Published: January 2023

IntroductionThe bad management of organic waste negatively affects environmental quality and composting has been a viable recycling alternative. Microorganisms are responsible for waste degradation during the composting process and, consequently, for transforming this waste into natural fertilizer. This work aimed to analyze and identify the biodiversity of yeasts and filamentous fungi throughout a composting process based on organic residues under different treatments (commercial inoculum, non-commercial inoculum, and control treatment) and to investigate the enzymatic activity of these microorganisms.MethodsMicroorganisms were isolated and identified from samples at 0, 5, 10, 20, 40, 60, and 120 days. Filamentous fungi were identified according to their macroscopic and microscopic characteristics, and yeasts were identified by sequencing the 18S rDNA region. All identified strains were evaluated for ligninolytic, cellulolytic, hemicellulolytic, amylolytic, pectinolytic, proteolytic, lipolytic, and ammonification. During the composting phases, the filamentous fungi were higher than the yeast population.Results and discussionAt the beginning of the process, a higher species diversity was observed, and the population of yeasts and filamentous fungi was, on average, 6.50 log CFU g−1. The microbial communities were similar throughout the process in the two inoculated treatments, which showed more significant microbial activity, diversity, and efficiency in the transformation of organic matter, and consequently, advantages in terms of the final product quality compared to the control treatment. The yeasts Pichia kudriavzevii, Pichia farinosa, Issatchenkia orientalis, and the filamentous fungi of the genus Aspergillus spp. proved to have high biotechnological value and could be used as starter cultures to accelerate the composting process.
Treatment of gorham-stout disease with bisphosphonates and total hip arthroplasty: A case report
Authors: Zhang LiQian , Li JianJian , Yao Fei , Chen YiHao , Zhang Shuo , Lv Hao , Jing JueHua 
Published: January 2023

BackgroundGorham-Stout disease (GSD) is a rare osteolytic disease with unknown etiology, varied clinical manifestations and unpredictable prognosis. This disease is characterized by progressive massive local osteolysis and resorption caused by intraosseous lymphatic vessel structure and thin-walled vascular proliferation. The diagnosis of GSD has not yet formed a uniform standard, but the combination of clinical manifestations, radiological features and unique histopathological examinations and excluding other diseases contribute to early diagnosis. Although medical therapy, radiotherapy and surgical interventions or combinations have been used for the treatment of GSD, there is currently still no recommended standardized treatment regimen.Case reportThis paper presents a case of a previously healthy 70-year-old man presented with a 10-year history of severe right hip pain and progressive walking disorder of the lower limbs. Based on the patient's clear clinical presentation, unique radiological features, and histological findings, a diagnosis of GSD was made with the exclusion of other potential diseases. The patient was treated with bisphosphonates to slow the progression of the disease followed by total hip arthroplasty to help restore walking function. At the 3-year follow-up, the patient returned to normal walking and no recurrence was observed.ConclusionBisphosphonates combined with total hip arthroplasty may be an effective method for the treatment of severe GSD in the hip joint.
Predictors of surgical site infection following reconstructive flap surgery: A multi-institutional analysis of 37,177 patients
Authors: Hassan Bashar , Abou Koura Abdulghani , Makarem Adham , Abi Mosleh Kamal , Dimassi Hani , Tamim Hani , Ibrahim Amir 
Published: January 2023

PurposeRates of surgical site infection (SSI) following reconstructive flap surgeries (RFS) vary according to flap recipient site, potentially leading to flap failure. This is the largest study to determine predictors of SSI following RFS across recipient sites.MethodsThe National Surgical Quality Improvement Program database was queried for patients undergoing any flap procedure from years 2005 to 2020. RFS involving grafts, skin flaps, or flaps with unknown recipient site were excluded. Patients were stratified according to recipient site: breast, trunk, head and neck (H&amp;N), upper and lower extremities (UE&amp;LE). The primary outcome was the incidence of SSI within 30 days following surgery. Descriptive statistics were calculated. Bivariate analysis and multivariate logistic regression were performed to determine predictors of SSI following RFS.Results37,177 patients underwent RFS, of whom 7.5% (n = 2,776) developed SSI. A significantly greater proportion of patients who underwent LE (n = 318, 10.7%) and trunk (n = 1,091, 10.4%) reconstruction developed SSI compared to those who underwent breast (n = 1,201, 6.3%), UE (n = 32, 4.4%), and H&amp;N (n = 100, 4.2%) reconstruction (p &lt; .001). Longer operating times were significant predictors of SSI following RFS across all sites. The strongest predictors of SSI were presence of open wound following trunk and H&amp;N reconstruction [adjusted odds ratio (aOR) 95% confidence interval (CI) 1.82 (1.57–2.11) and 1.75 (1.57–1.95)], disseminated cancer following LE reconstruction [aOR (CI) 3.58 (2.324–5.53)], and history of cardiovascular accident or stroke following breast reconstruction [aOR (CI) 16.97 (2.72–105.82)].ConclusionLonger operating time was a significant predictor of SSI regardless of reconstruction site. Reducing operating times through proper surgical planning might help mitigate the risk of SSI following RFS. Our findings should be used to guide patient selection, counseling, and surgical planning prior to RFS.
Assessment of preoperative anxiety and depression in patients with pulmonary ground-glass opacities: Risk factors and postoperative outcomes
Authors: Han Yu , Yu Qiduo , Ma Qianli , Zhang Jin , Shi Yuhui , Zhang Zhenrong , Qiang Guangliang , Xiao Fei , Liang Chaoyang 
Published: January 2023

ObjectiveA large number of patients with pulmonary ground-glass opacities (GGOs) have anxiety and depression. However, the contributing factors and effects of anxiety and depression on postoperative outcomes are still unclear.MethodsClinical data for patients undergoing surgical resection for pulmonary GGOs were collected. We prospectively evaluated levels and risk factors for anxiety and depression in patients with GGOs before surgery. The relationship between psychological disorders and postoperative morbidity was evaluated. Quality of life (QoL) was also assessed.ResultsA total of 133 patients were enrolled. Prevalence rates of preoperative anxiety and depression were 26.3% (n = 35) and 18% (n = 24), respectively. Multivariate analysis revealed depression [odds ratio(OR) = 16.27, p &lt; 0.001] and multiple GGOs (OR = 3.146, p = 0.033) to be risk factors for preoperative anxiety. Anxiety (OR = 52.166, p &lt; 0.001), age &gt; 60 (OR = 3.601, p = 0.036), and unemployment (OR = 8.248, p = 0.006) were identified as risk factors for preoperative depression. Preoperative anxiety and depression were associated with lower QoL and higher postoperative pain scores. Our results also revealed that the incidence of postoperative atrial fibrillation was higher in patients with than in those without anxiety.ConclusionsIn patients with pulmonary GGOs, comprehensive psychological assessment and appropriate management are required before surgery to improve QoL and reduce postoperative morbidity.
A prediction model for in-hospital mortality in intensive care unit patients with metastatic cancer
Authors: Wu Meizhen , Gao Haijin 
Published: January 2023

AimTo identify predictors for in-hospital mortality in patients with metastatic cancer in intensive care units (ICUs) and established a prediction model for in-hospital mortality in those patients.MethodsIn this cohort study, the data of 2,462 patients with metastatic cancer in ICUs were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. Least absolute shrinkage and selection operator (LASSO) regression analysis was applied to identify the predictors for in-hospital mortality in metastatic cancer patients. Participants were randomly divided into the training set (n = 1,723) and the testing set (n = 739). Patients with metastatic cancer in ICUs from MIMIC-IV were used as the validation set (n = 1,726). The prediction model was constructed in the training set. The area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were employed for measuring the predictive performance of the model. The predictive performance of the model was validated in the testing set and external validation was performed in the validation set.ResultsIn total, 656 (26.65%) metastatic cancer patients were dead in hospital. Age, respiratory failure, the sequential organ failure assessment (SOFA) score, the Simplified Acute Physiology Score II (SAPS II) score, glucose, red cell distribution width (RDW) and lactate were predictors for the in-hospital mortality in patients with metastatic cancer in ICUs. The equation of the prediction model was ln(P/(1 + P)) = −5.9830 + 0.0174 × age + 1.3686 × respiratory failure + 0.0537 × SAPS II + 0.0312 × SOFA + 0.1278 × lactate − 0.0026 × glucose + 0.0772 × RDW. The AUCs of the prediction model was 0.797 (95% CI,0.776–0.825) in the training set, 0.778 (95% CI, 0.740–0.817) in the testing set and 0.811 (95% CI, 0.789–0.833) in the validation set. The predictive values of the model in lymphoma, myeloma, brain/spinal cord, lung, liver, peritoneum/pleura, enteroncus and other cancer populations were also assessed.ConclusionThe prediction model for in-hospital mortality in ICU patients with metastatic cancer exhibited good predictive ability, which might help identify patients with high risk of in-hospital death and provide timely interventions to those patients.
Dietary spirulina supplementation modifies rumen development, fermentation and bacteria composition in Hu sheep when consuming high-fat dietary
Authors: Wang Zhibo , Liang Yaxu , Lu Jiawei , Wei Zongyou , Bao Yongjin , Yao Xiaolei , Fan Yixuan , Wang Feng , Wang Daxiang , Zhang Yanli 
Published: January 2023

IntroductionThis study aims to investigate the long-term effects of spirulina supplementation in a high-fat diet (HFD) on rumen morphology, rumen fermentation, and the composition of rumen microbiota in lambs. Spirulina is a blue-green microalgae that has been shown to have high nutritional value for livestock.MethodsFifty-four lambs were randomly divided into three groups: a normal chow diet (NCD) group, a high-fat diet (HFD) group, and a high-fat diet supplemented with 3% spirulina (HFD+S) group. Rumen morphology, rumen fermentation, and rumen microbiota were analyzed at the end of the study.ResultsSpirulina supplementation improved the concentration of volatile fatty acids and rumen papilla length. Additionally, there was a tendency for an increase in rumen weight and an upregulation of the genes Claudin-1, Claudin-4, and Occludin in the HFD+S group. Pyrosequencing of the 16S ribosomal RNA gene also showed that spirulina supplementation significantly changed the rumen microbiota composition in the HFD group, with a decrease in richness and diversity. Specifically, the relative abundance of Prevotella 9 and Megasphaera was significantly increased in the HFD group compared to the NCD group, while spirulina supplementation reversed these changes.DiscussionThis study suggests that 3% spirulina supplementation can improve rumen development and fermentation, and effectively relieve rumen microbe disorders in lambs caused by a high-fat diet. However, further research is needed to confirm the findings and to examine the long-term effects of spirulina supplementation in different types of livestock and under different dietary conditions.
Analysis of Whole-Genome Sequences of Pathogenic Gram-Positive and Gram-Negative Isolates from the Same Hospital Environment to Investigate Common Evolutionary Trends Associated with Horizontal Gene Exchange, Mutations and DNA Methylation Patterning
Authors: Korotetskiy Ilya S. , Shilov Sergey V. , Kuznetsova Tatyana , Kerimzhanova Bahkytzhan , Korotetskaya Nadezhda , Ivanova Lyudmila , Zubenko Natalya , Parenova Raikhan , Reva Oleg N. 
Published: January 2023

Hospital-acquired infections are a generally recognized problem for healthcare professionals. Clinical variants of Gram-negative and Gram-positive pathogens are characterized with enhanced antibiotic resistance and virulence due to mutations and the horizontal acquisition of respective genetic determinants. In this study, two Escherichia coli, two Klebsiella pneumoniae, three Pseudomonas aeruginosa, two Staphylococcus aureus, one Staphylococcus epidermidis and one Streptococcus pneumoniae showing broad spectra of antibiotic resistance were isolated from patients suffering from nosocomial infections in a local hospital in Almaty, Kazakhstan. The aim of the study was to compare general and species-specific pathways of the development of virulence and antibiotic resistance through opportunistic pathogens causing hospital-acquired infections. The whole-genome PacBio sequencing of the isolates allowed for the genotyping and identification of antibiotic resistance and virulence genetic determinants located in the chromosomes, plasmids and genomic islands. It was concluded that long-read sequencing is a useful tool for monitoring the epidemiological situation in hospitals. Marker antibiotic resistance mutations common for different microorganisms were identified, which were acquired due to antibiotic-selective pressure in the same clinical environment. The genotyping and identification of strain-specific DNA methylation motifs were found to be promising in estimating the risks associated with hospital infection outbreaks and monitoring the distribution and evolution of nosocomial pathogens.
RESEARCH OF THE MINERAL NATURAL RESOURCE CONSTRUCTION
Authors: Саламанова М. Ш. , Нахаев М. Р. , Муртазаева Т. С-А. 
Published: January 2023

При всей значимости гидравлического портландцемента всемирная федерация Central Pollution Control Board относит карбонатную технологию к категории экологически вредных и опасных для окружающей среды. Обоснованием указанных доводов служат многие факторы, такие как крупно-масштабная добыча исчерпаемого природного ресурса, высокотемпературная обработка которого приводит к выбросам потенциально опасных для здоровья ультрадисперсной аспирационной и клинкерной пыли, углекислоты, сернистых соединений, тяжелых металлов, диоксинов и др. Снижение доли клинкера в составе вяжущего позволит создавать многокомпонентные цементные системы с использованием минеральных порошков, подвергнутых механо- или механохимической активации, что требует глубокого исследования их природы, условий формирования, обменной емкости и свойств в целом.
Despite the importance of hydraulic Portland cement, the global federation Central Pollution Control Board classifies carbonate technology as environmentally harmful and hazardous to the environment. These arguments are substantiated by many factors, such as large-scale mining of an exhaustible natural resource, the high-temperature processing of which leads to emissions of potentially hazardous ultrafine aspiration and clinker dust, carbon dioxide, sulfur compounds, heavy metals, dioxins, etc. Reducing the proportion of clinker in the binder composition will make it possible to create multicomponent cement systems using mineral powders subjected to mechanical or mechanochemical activation, which requires a deep study of their nature, formation conditions, exchange capacity and properties in general.
AUTOMATED POWER METERING SYSTEM IN THE ELECTRIC NETWORKS OF THE CHECHEN REPUBLICUSING WEB TECHNOLOGIES
Authors: Амхаев Т. Ш. , Дебиев М. В. , Масаев С. Х. 
Published: January 2023

Данная статья посвящена вопросам возникновения, развития и интегрирования автоматизированных систем учета электрической энергии с использованием web-технологий в наше время. Актуальность данной темы обусловлена тем, что с развитием технологий и их массовым распространением увеличивается нагрузка на электрические сети, происходит неоправданный и бесконтрольный расход электроэнергии, что, в свою очередь, приводит к ухудшению экосистемы всей планеты. Предлагается применение распределенной системы мониторинга качества электрической энергии, производить измерения значений электрических параметров на разных участках электрической сети, с последующим их преобразованием в соответствующие формы и передачей в единый центр управления. Такая структура также позволит вести постоянный контроль за уровнем гармонических составляющих в различных узлах энергосистемы.
This article is devoted to the issues of the emergence, development and integration of automated electric energy accounting systems using web technologies in our time. The relevance of this topic is due to the fact that with the development of technologies and their mass distribution, the load on electrical networks increases, there is an unjustified and uncontrolled consumption of electricity, which in turn leads to a deterioration of the ecosystem of the entire planet. It is proposed to use a distributed system for monitoring the quality of electrical energy, to measure the values of electrical parameters in different sections of the electrical network, with their subsequent transformation into appropriate forms and transfer to a single control center. Such a structure will also allow for constant monitoring of the level of harmonic components in various nodes of the power system.
Pemanfaatan Program Pemerintah Bantuan Langsung Tunai Di Desa Tambelang Kecamatan Maesaan Kabupaten Minahasa Selatan
Authors: Rumengan Fidel S. , Baroleh Jenny , Katiandagho Theodora M. 
Published: January 2023

This study aims to determine the direct cash assistance (BLT) program is right on target in terms of accuracy of recipient recruitment, disbursement time, supervision and to determine community utilization of the BLT Program in Tambelang Village, Maesaan District. The research was carried out from January to February 2022. The data collected in the study were primary data obtained from direct interviews with BLT recipient communities using a questionnaire. Secondary data were obtained from the Tambelang Village Office, as well as data related to research taken from the internet. The number of BLT recipients was 130 respondents who received BLT phase I in 2021 and phase II in 2021. The sample selected by Purposive Sampling was 60 respondents. The results showed that the use of the government's direct cash assistance program in Tambelang Village was appropriate, the recipients of the assistance had fulfilled the correct recruitment process in accordance with the implementation instructions, on time in disbursing funds, officers disbursed aid funds according to the specified schedule. The Government's Cash Direct Assistance Program is used by the community to meet their daily basic needs, namely buying rice, eggs, meat, transportation and for emergency funds, namely buying medicine and children's school needs.
Partisipasi Masyarakat Terhadap Pengelolaan Hutan Lindung Mangrove Di Desa Sarawet Kecamatan Likupang Timur Kabupaten Minahasa Utara
Authors: Sinaga Fransisco Daniel , Memah Melsje Yellie , Timban Jean Fany Junita 
Published: January 2023

This study aims to determine the level of community participation and to analyze the relationship between internal and external factors with the level of community participation in the management of mangrove protected forests in Sarawet Village, Likupang Timur District, North Minahasa Regency. This research was conducted from December 2021 to February 2022. The selection of respondents was carried out by accidental sampling. The data used are primary data and secondary data. Primary data were collected through questionnaire-based interviews with 76 people. Secondary data was obtained from related agencies, namely the Old Law Office of Sarawet Village, North Minahasa Regency. Secondary data was also obtained through the internet using Google Scholar in the form of books, journal articles and theses related to the topic of this research, namely Community Participation in Mangrove Protected Forest Management. The results showed that the level of community participation in Sarawet Village, East Likupang District in the planning, implementation, utilization and evaluation stages was low and the relationship between internal and external factors on community participation as a whole had a significant relationship with a sig value of 0.000 < 0.01.