bluuebunny/crossref_metadata_2025_split huggingface dataset:
Achieving Tunable Selectivity and Activity of CO2 Electroreduction to CO via Bimetallic Silver–Copper Electronic Engineering
Authors: Li Meng , Hu Yue , Dong Gang , Wu Tianci , Geng Dongsheng 
Published: January 2023

AbstractLimited comprehension of the reaction mechanism has hindered the development of catalysts for CO2 reduction reactions (CO2RR). Here, the bimetallic AgCu nanocatalyst platform is employed to understand the effect of the electronic structure of catalysts on the selectivity and activity for CO2 electroreduction to CO. The atomic arrangement and electronic state structure vary with the atomic ratio of Ag and Cu, enabling tunable d‐band centers to optimize the binding strength of key intermediates. Density functional theory calculations confirm that the variation of Cu content greatly affects the free energy of *COOH, *CO (intermediate of CO), and *H (intermediates of H2), which leads to the change of the rate‐determining step. Specifically, Ag96Cu4 reduces the free energy of the formation of *COOH while maintaining a relatively high theoretical overpotential for hydrogen evolution reaction(HER), thus achieving the best CO selectivity. While Ag70Cu30 shows relatively low formation energy of both *COOH and *H, the compromised thermodynamic barrier and product selectivity allows Ag70Cu30 the best CO partial current density. This study realizes the regulation of the selectivity and activity of electrocatalytic CO2 to CO, which provides a promising way to improve the intrinsic performance of CO2RR on bimetallic AgCu.
Single Cobalt Atoms Immobilized on Palladium‐Based Nanosheets as 2D Single‐Atom Alloy for Efficient Hydrogen Evolution Reaction
Authors: Yang Shuai , Si Zhihao , Li Guozhen , Zhan Peng , Liu Chang , Lu Lu , Han Buxing , Xie Haijiao , Qin Peiyong 
Published: January 2023

AbstractSingle‐atom alloys (SAAs) display excellent electrocatalytic performance by overcoming the scaling relationships in alloys. However, due to the lack of a unique structure engineering design, it is difficult to obtain SAAs with a high specific surface area to expose more active sites. Herein, single Co atoms are immobilized on Pd metallene (Pdm) support to obtain Co/Pdm through the design of the engineered morphology of Pd, realizing the preparation of ultra‐thin 2D SAA. The unsaturated coordination environments combined with the unique geometric and electronic structures realize the modulation of the d‐band center and the redistribution of charges, generating highly active electronic states on the surface of Co/Pdm. Benefiting from the synergistic interaction and spillover effect, the Co/Pdm electrocatalyst exhibits outstanding hydrogen evolution reaction (HER) performance in both acid and alkaline solutions, especially with a Tafel slope of 8.2 mV dec−1 and a low overpotential of 24.7 mV at 10 mA cm−2 in the acidic medium, which outperforms commercial Pt/C and Pd/C. This work highlights the successful preparation of 2D ultra‐thin SAA, which provides a new strategy for the preparation of HER electrocatalyst with high efficiency, activity, and stability.
Reconstruction of tunnel lining rebars from terrestrial laser scanning data
Authors: Cheng Yun‐Jian , Zheng Wan‐Lan , Qiu Wen‐Ge 
Published: January 2023

AbstractIncorrect rebar placement has led to serious concrete structural failures; thus, site inspectors must ensure that the rebars placed are compliant with as‐designed drawings before tunnel lining concreting. This paper aims to develop a methodology that automatically segments the semantics (e.g., main rebar and distribution rebar) and instances of curved rebars and reconstructs the tunnel lining rebars from the raw point clouds. There are five main parts in the proposed methodology: rebar mesh reshaping, rebar mesh extraction and refinement, semantic segmentation, instance labeling, and rebar mesh modeling. To validate the developed methodology, an experiment was conducted on the rebar point cloud of a high‐speed railway tunnel. The evaluation of the accuracies of segmentation was conducted by comparisons with the existing methods and manually labeled ground truth data. The results show that the rebar segmentation has high precision values with the acceptable recall values, and that the rebar models reconstructed achieve millimeter‐level (about 2 mm) accuracy.
Stone ablation efficacy: a comparison of a thulium fibre laser and two pulse-modulated holmium:YAG lasers
Authors: Yang Bingyuan , Ray Aditi , Zhang Jian James , Peng Steven , O’Brien Mike , Turney Ben 
Published: January 2023

AbstractWe present preliminary stone ablation rate results from an automated bench model using two pulse-modulated Ho:YAG lasers and a thulium fibre laser (TFL) in contact and non-contact modes. Ablation rate was assessed using automated apparatus that moved the laser fibre across flat BegoStone phantoms at a constant stone-to-fibre working distance (WD). Pre-soaked and unsoaked stones were used. A range of powers (20–60 W) was tested at WD of up to 3 mm. In pseudocontact, the prototype Ho:YAG laser produced higher ablation than the reference Ho:YAG laser at all powers tested (p < 0.002), and higher ablation than TFL at 20 W and 40 W (p < 0.001). At distance, ablation rates for the prototype were higher than the reference Ho:YAG laser using pre-soaked stones at WD up to 3 mm (p < 0.001). TFL required the laser fibre to be moved faster (5–12 mm/s) for optimal ablation, compared to 1–3 mm/s for the Ho:YAG lasers. TFL was unable to demonstrate ablation with unsoaked BegoStone. At any given power, similar ablation rates were achievable with all three lasers under optimised conditions. Novel pulse-modulation modes demonstrated higher ablation rates than the reference Ho:YAG laser’s pulse-modulation at a range of powers and WDs. Ablation rate of Ho:YAG lasers decreased linearly with WD whereas the ablation rate of TFL decreased rapidly beyond 2 mm WD. TFL was more affected by scan speed and pre-soaking of stone than Ho:YAG lasers. Ho:YAG lasers may be more practical in clinical settings because they are less dependent on ablation technique.
Fludarabine plus reduced-intensity busulfan versus fludarabine plus myeloablative busulfan in patients with non-Hodgkin lymphoma undergoing allogeneic hematopoietic cell transplantation
Authors: Kamijo Kimimori , Shimomura Yoshimitsu , Shinohara Akihito , Mizuno Shohei , Kanaya Minoru , Usui Yoshiaki , Kim Sung-Won , Ara Takahide , Mizuno Ishikazu , Kuriyama Takuro , Nakazawa Hideyuki , Matsuoka Ken-ichi , Kusumoto Shigeru , Maseki Nobuo , Yamaguchi Masaki , Ashida Takashi , Onizuka Makoto , Fukuda Takahiro , Atsuta Yoshiko , Kondo Eisei 
Published: January 2023

Abstract Allogeneic hematopoietic cell transplantation (HCT) offers a possible cure for patients with relapsed and refractory non-Hodgkin lymphoma (NHL) through potentially beneficial graft versus lymphoma effects. However, allogeneic HCT is associated with high nonrelapse mortality (NRM). Fludarabine with reduced-intensity busulfan (Flu/Bu2) and myeloablative busulfan (Flu/Bu4) are commonly used in conditioning regimens for allogeneic HCT; however, data on their use in patients with NHL is limited. We investigated the effect of busulfan dose on outcomes by comparing Flu/Bu2 and Flu/Bu4 in patients with NHL who underwent allogeneic HCT. Our study included 415 adult patients with NHL who received Flu/Bu2 (315 patients) or Flu/Bu4 (100 patients) between January 2008 and December 2019. All patients were enrolled in the Transplant Registry Unified Management Program 2 of the Japanese Data Center for Hematopoietic Cell Transplantation. The primary endpoint was the 5-year overall survival (OS). To minimize potential confounding factors that may influence outcomes, we performed propensity score matching. The 5-year OS was 50.6% (95% confidence interval (CI), 39.4%–60.8%) and 32.2% (95% CI, 22.4–42.4%) in the Flu/Bu2 and Flu/Bu4 groups, respectively (p = 0.006). The hazard ratio comparing the two groups was 2.13 (95% CI, 1.30–3.50; p = 0.003). Both groups had a similar 5-year cumulative incidence of relapse (38.2% vs 41.3%; p = 0.581), and the Flu/Bu4 group had a higher cumulative incidence of 5-year NRM (15.7% vs 31.9%; p = 0.043). In this study, Flu/Bu4 was associated with worse OS compared with Flu/Bu2 because of high NRM in patients with NHL.
oregis – Das deutsche ophthalmologische Register
Authors: Storp Jens Julian , Dicke Christopher , Böhringer Daniel , Schargus Marc , Eter Nicole 
Published: January 2023

Zusammenfassung
Hintergrund
Medizinische Register haben ihr Potenzial zur Versorgungsforschung in unterschiedlichen Bereichen des Gesundheitswesens bereits in der Vergangenheit zeigen können. Die Vereinigten Staaten von Amerika (USA) verfügen über das bekannte nationale ophthalmologische Register IRIS® (Intelligent-Research-In-Sight), auf dessen Grundlage Erkenntnisse zur ophthalmologischen Versorgungslage in den USA gewonnen werden können. Vergleichbare Projekte existieren in Deutschland gegenwärtig nicht. oregis ist das erste krankheitsübergreifende Register, das umfassende Daten auf dem Gebiet der Augenheilkunde in Deutschland zum Zweck der Versorgungsforschung sammelt.

Methoden
oregis trägt derzeit anonymisierte, klinische Patienteninformationen aus allen Teilbereichen der Augenheilkunde zusammen und stellt diese zu Forschungszwecken zur Verfügung. Teilnehmende Zentren lesen ihre Daten unentgeltlich und vorzugsweise automatisiert in das Register ein. Derzeit zählt die oregis-Parameterliste ca. 600 Parameter, wovon etwa 100 in der aktuellen Pilotphase eingesetzt werden.

Ergebnisse
Das deutsche ophthalmologische Register oregis hat seit seiner Initiierung Daten zu über 1,75 Mio. Arztbesuchen von über 400.000 Patientinnen und Patienten aus deutschen ophthalmologischen Zentren zusammengetragen. Bis zum Spätsommer 2022 wurden über 2,8 Mio. Visus- und gleich viele Tensiomessungen erfasst.

Diskussion
Ziel des Projektes ist die Einrichtung einer bundesweiten ophthalmologischen Datenbank, die die Grundlage für ein lernendes Gesundheitssystem auf dem Gebiet der Augenheilkunde bildet. Mithilfe einer fortwährenden Aktualisierung kann oregis auch kurzfristige Neuerungen in der augenärztlichen Versorgung abbilden.
Surgical management in hepatoblastoma: points to take
Authors: Murawski Maciej , Weeda Viola B. , Czauderna Piotr 
Published: January 2023

AbstractHepatoblastoma is the most common primary malignant paediatric liver tumour and surgery remains the cornerstone of its management. The aim of this article is to present the principles of surgical treatment of hepatoblastoma. All aspects of surgery in hepatoblastoma are discussed, from biopsy, through conventional and laparoscopic liver resections, to extreme resection with adjacent structures, staged hepatectomy and transplantation.
A novel approach of tool condition monitoring in sustainable machining of Ni alloy with transfer learning models
Authors: Ross Nimel Sworna , Sheeba Paul T. , Shibi C. Sherin , Gupta Munish Kumar , Korkmaz Mehmet Erdi , Sharma Vishal S 
Published: January 2023

AbstractCutting tool condition is crucial in metal cutting. In-process tool failures significantly influences the surface roughness, power consumption, and process endurance. Industries are interested in supervisory systems that anticipate the health of the tool. A methodology that utilizes the information to predict problems and to avoid failures must be embraced. In recent years, several machine learning-based predictive modelling strategies for estimating tool wear have been emerged. However, due to intricate tool wear mechanisms, doing so with limited datasets confronts difficulties under varying operating conditions. This article proposes the use of transfer learning technology to detect tool wear, especially flank wear under distinct cutting environments (dry, flood, MQL and cryogenic). In this study, the state of the cutting tool was determined using the pre-trained networks like AlexNet, VGG-16, ResNet, MobileNet, and Inception-V3. The best-performing network was recommended for tool condition monitoring, considering the effects of hyperparameters such as batch size, learning rate, solver, and train-test split ratio. In light of this, the recommended methodology may prove to be highly helpful for classifying and suggesting the suitable cutting conditions, especially under limited data situation. The transfer learning model with Inception-V3 is extremely useful for intelligent machining applications.
Effect of Surface Cleaning Process on the Wafer Bonding of Silicon and Pyrex Glass
Authors: Du Chao , Zhao Yali , Li Yong 
Published: January 2023

AbstractAnodic bonding is a reliable packaging method for MEMS devices, and the surface properties of the wafer directly affect the bonding efficiency. Therefore, the surface treatment of the wafer to be bonded is necessary. Herein, the effects of three different surface cleaning processes (degreasing, piranha solution and RCA solution) on the wafer surface were investigated by atomic force microscopy, scanning electron microscopy, infrared spectroscopy, and anodic bonding experiments. The analysis showed that during the anodic bonding of the RCA solution-cleaned wafer and Pyrex glass, the bonding interface was more closely attached, and the best surface properties were obtained. The anodic bonding experiments of the wafer and Pyrex glass showed that the bonding current increased with the applied voltage, and the bonding time decreased accordingly. This was most evident in the case of RCA cleaning. The SEM images showed that as the bonding voltage increased, the bonding interface became more uniform without obvious voids. Due to the influence of the strong electric field and temperature field, an irreversible chemical reaction occurred at the bonding interface, which formed a bonding layer that was key to successful bonding.
Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration
Authors: Yau Grace Tsz Yan , Tai Waiting , Arnold Jonathon Carl , Chan Hak-Kim , Kwok Philip Chi Lip 
Published: January 2023

AbstractThe use of cannabidiol (CBD) for treating brain disorders has gained increasing interest. While the mechanism of action of CBD in these conditions is still under investigation, CBD has been shown to affect numerous different drug targets in the brain that are involved in brain disorders. Here we review the preclinical and clinical evidence on the potential therapeutic use of CBD in treating various brain disorders. Moreover, we also examine various drug delivery approaches that have been applied to CBD. Due to the slow absorption and low bioavailability with the current oral CBD therapy, more efficient routes of administration to bypass hepatic metabolism, particularly pulmonary delivery, should be considered. Comparison of pharmacokinetic studies of different delivery routes highlight the advantages of intranasal and inhalation drug delivery over other routes of administration (oral, injection, sublingual, buccal, and transdermal) for treating brain disorders. These two routes of delivery, being non-invasive and able to achieve fast absorption and increase bioavailability, are attracting increasing interest for CBD applications, with more research and development expected in the near future.
Texture Development During Annealing in a Low-Carbon Formable Steel Containing Impurities from Increased Scrap Use
Authors: Duan Jiaqi , Farrugia Didier , Davis Claire , Li Zushu 
Published: January 2023

Abstract
Impurities (Cu, Sn, Cr, and Ni) have been added to a low-carbon formable strip steel to simulate the scenario of increased use of scrap during steel production. Texture evolution during annealing of the cold-rolled base steel and impurity-added steel have been investigated. The impurities were shown to suppress the development of the γ-fiber texture. Meanwhile, a higher fraction of random orientations was developed in the impurity-added steel. However, the adverse effect of impurities on the γ-fiber was mitigated during annealing at higher temperatures (650 °C to 750 °C). The correlation between texture development and microstructure heterogeneity, and the effect of impurity additions on texture development are discussed. This work provides guidelines on recycling scrap for the production of low-carbon formable steels.
pH-dependent color response of cellulose-based time-temperature indicators impregnated with red cabbage extract
Authors: Halász Katalin , Kóczán Zsófia , Joóbné Preklet Edina 
Published: January 2023

AbstractColor-based time-temperature indicators (TTIs) can show the time and temperature changes of an environment with a visually recognizable color change. Made from natural dyes, these TTIs are simple, inexpensive and sustainable. In this study, cellulose-based TTI labels were prepared with red cabbage extract of pH2, pH7 and pH9 to determine how pH alter the response of the labels to time and temperature changes. This study also aimed to determine the relationship between color change and time at different temperatures. The color responses of the labels were followed spectrophotometrically by measuring the CIE Lab color coordinates and by giving the total color difference at 4 °C, 23 °C, 40 °C, 80 and 100 °C after increments of time. The best fitting linear or nonlinear regression models of the CIE Lab coordinates, total color difference and time data as a function of temperature were also determined. The labels prepared with red cabbage extract at different pH behaved differently. Opposite to expectations, the acidic, pink colored labels did not have the highest color stability. Our finding was, that the label prepared with the acidic red cabbage extract is the most suitable as time-temperature label for indicating long-term temperature storage and the label prepared with the neutral red cabbage extract is the most suitable as time-temperature label for indicating short-term storage by color change. According to the results the color changes of the labels are predictable with the fitted models with a correlation coefficient between 0.96 and 1.
Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes
Authors: Mazzilli R. , Rucci C. , Vaiarelli A. , Cimadomo D. , Ubaldi F. M. , Foresta C. , Ferlin A. 
Published: January 2023

Abstract
Background
Infertility, which is defined as the inability to conceive after at least 12 months of regular unprotected sexual intercourses, affects about 15–20% of couples worldwide and a male factor is involved in about half of the cases. The development of assisted reproductive technology (ART) made it possible to conceive also to individuals affected from severe oligospermia or azoospermia. However, the impact of the male factor on embryo development, implantation, prevalence of chromosomal abnormalities, genetic and epigenetic alterations, and clinical and obstetric outcomes is still controversial.

Purpose
This narrative review examines the indications, minimum access criteria, and outcomes by individual ART technique in relation to the male factor.
Soundscape in city and built environment: current developments and design potentials
Authors: Kang Jian 
Published: January 2023

AbstractIn the field of environmental acoustics, the conventional approach of reducing ‘sound level’ does not always deliver the required improvements in quality of life. Soundscape, defined by the ISO as the ‘acoustic environment as perceived or experienced and/or understood by a person or people, in context’, promotes a holistic approach, regarding sounds as ‘resources’ rather than just ‘wastes’. The first part of this review/position paper, mainly using the works by the author and the teams/collaborators as examples, discusses the current developments in soundscape, in terms of soundscape understating and exchanging, collecting and documenting, harmonising and standardising, creating and designing, and outreaching, showing that while considerable works have been carried out, much work is still needed, in terms of basic research, and more importantly, research towards practice. The second part of this paper then explores a soundscape approach in the urban sound design/planning process. With a proposed framework for designing soundscape in urban open public spaces, considering four key components, including characteristics of each sound source, acoustic effects of the space, social/demographic aspect of the users, and other physical conditions, design potentials are demonstrated.
Evaluation on the tracer simulation under different advection schemes in the ocean model
Authors: Wu Hui 
Published: January 2023

AbstractAdvection scheme is one of the core challenges in the computational fluid dynamics, which restricts the capacity of model performance in many research areas including the oceanographic modelling studies. Here in this study, we compared the newly developed algorithm HSIMT (advection scheme with High-order Spatial Interpolation at the Middle Temporal level) with the well-known scheme MPDATA (Multidimensional Positive-Definite Advective Transport Algorithm), in the 1-dimensional idealized simulation and the 3-dimensional realistic river plume simulations. The river plume simulation was done with a mainstream ocean model ROMS (Regional Ocean Modeling System). The results showed that in the 1-dimensional test both HSIMT and MPDATA can converge to the analytical results, but HSIMT converges much faster and does not produce overshooting around the sharp front. Accuracy of HSIMT is also free from the choice of timestep, unlike MPDATA. In the ROMS simulation of a surface-trapped river plume, HSIMT also showed great advantages. Results simulated by MPDATA is highly relied on the model resolution, but when the resolution is high enough the results approached to that simulated by HSIMT. The results of this study could assist the further understanding on capacity of advection schemes and further promote the developments of ocean models.
OOCDB: A Comprehensive, Systematic, and Real-Time Organs-on-a-Chip Database
Authors: Li Jian , Liang Weicheng , Chen Zaozao , Li Xingyu , Gu Pan , Liu Anna , Chen Pin , Li Qiwei , Mei Xueyin , Yang Jing , Liu Jun , Jiang Lincao , Gu Zhongze 
Published: January 2023

Abstract
Organs-on-a-chip is a microfluidic microphysiological system that uses microfluidic technology to analyze the structure and function of living human cells at the tissue and organ levels in vitro. Organs-on-a-chip technology, as opposed to traditional two-dimensional cell culture and animal models, can more closely simulate pathologic and toxicologic interactions between different organs or tissues and reflect the collaborative response of multiple organs to drugs. Despite the fact that many organs-on-a-chip-related data have been published, none of the current databases have all of the following functions: searching, downloading, as well as analyzing data and results from the literature on organs-on-a-chip. Therefore, we created an organs-on-a-chip database (OOCDB) as a platform to integrate information about organs-on-a-chip from various sources, including literature, patents, raw data from microarray and transcriptome sequencing, several open-access datasets of organs-on-a-chip and organoids, and data generated in our laboratory. OOCDB contains dozens of sub-databases and analysis tools, and each sub-database contains various data associated with organs-on-a-chip, with the goal of providing researchers with a comprehensive, systematic, and convenient search engine. Furthermore, it offers a variety of other functions, such as mathematical modeling, three-dimensional modeling, and citation mapping, to meet the needs of researchers and promote the development of organs-on-a-chip. The OOCDB is available at http://www.organchip.cn.