bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining the effectiveness of using acoustic velocity as an indirect measurement of branchiness in standing longleaf pine
Authors: Hausle Jacks M.T. , Forrester Jodi A. , Walker Trevor D. 
Published: June 2023

Branches reduce stem quality, and the level of the effect is determined by the geometry, size, and number, of associated knots. Quantifying branchiness is difficult, as visual estimates are subjective, and mechanical measurements are impractical. Acoustic velocity (AV) is a relatively novel measurement capturing the speed stress travels through wood. AV is correlated with wood stiffness and is affected by internal characteristics like knots. This project tested AV as an indirect branchiness metric by measuring AV, height, diameter, and counting branches classified by diameter on 255 standing 8 year old longleaf pine ( Pinus palustris). AV was highly correlated with height (r = 0.76, p < 0.0001) and slenderness (r = 0.52, p < 0.0001). AV was moderately correlated with large living branches (diameter > 2.54 cm) (r = −0.27, p < 0.0001), but not correlated with total branches. Height, slenderness, and the count of large living branches (diameter > 2.54 cm) were included in the selected model for AV. Inclusion of dead or small (diameter < 2.54 cm) branches reduced model power. The best model captured 11% of the variation in AV, of which branches explained 5%. We conclude that AV does not appropriately quantify individual tree branchiness, but may be suitable for comparing populations such as families or provenances.
Evaluating the biosusceptibility of natural stone as an supporting tool to prevent Cultural Heritage biodeterioration
Authors: Dias L. , Pires V. , Sitzia F. , Lisci C. , Candeias A. , Caldeira A. T. , Mirão J. 
Published: June 2023

AbstractBiodeterioration of construction materials is still a major challenge that conservator-restorers face, especially in historic monuments with high cultural value. Natural stone is highly susceptible to deterioration through physical, chemical, and biological ways, whereas biological proliferation may potentiate both chemical and physical deterioration. The composition of the colonizers and their proliferation are highly dependent on climatic parameters like temperature and humidity, which are distinct from place to place. The present work proposes the execution of an innovative methodology that enables the determination of the susceptibility of natural stone to biocolonization, a parameter denominated as biosusceptibility. The study aims to contribute to the creation of models by predicting their deterioration even before the objects’ manufacture, promoting the sustainability of one of the most valuable natural resources. The methodology proposed here was performed on limestones, marbles and slates—exploited in the Portuguese territory—by using colonizing strains typically found on stones exposed to the Mediterranean climate. The results have demonstrated that the stones with higher porosity are less susceptible to epilithic colonization and, consequently, with a moderate alteration of their aesthetic appearance. However, the metabolic activity determined in these stones is higher, which indicates that biocolonization will cause more severe damage to their structure in the future. The first significant changes on the stones’ matrix were assessed one year after the inoculation, using cutting-edge technology of 3D surface micro-reconstruction. Due to its relevance in natural stone deterioration processes, the inclusion of the biosusceptibility information in technical brochures is strongly encouraged.
Graphical Abstract
Visual Gaze Patterns in the Analysis of Glottic Lesions: Does Experience Increase Diagnostic Accuracy?
Authors: Armstrong Michael F. , Orbelo Diana M. , Wallerius Katherine P. , Lebechi Chiamaka A. , Lohse Christine M. , Dey Jacob K. , Bayan Semirra L. 
Published: June 2023

Objectives: The purpose of this study was to evaluate visual gaze patterns and the ability to correctly identify cancer among participants of different experience levels when viewing benign and malignant vocal cord lesions. Methods: Thirty-one participants were divided into groups based on level of experience. These included novice (medical students, PGY1-2 otolaryngology residents), intermediate (PGY3-5 otolaryngology residents, gastroenterology fellow), advanced practice providers (physician assistants, nurse practitioners, and speech language pathologists), and experts (board-certified otolaryngologists). Each participant was shown 7 images of vocal cord pathology including glottic cancer, infectious laryngitis, and granuloma and asked to determine the likelihood of cancer on a scale of certain, probable, possible, and unlikely. Eye tracking data were collected and used to identify the area of interest (AOI) that each participant fixated on first, fixated on the longest, and had the greatest number of fixations. Results: No significant differences were seen among groups when comparing AOI with first fixation, AOI with longest fixation, or AOI with most fixations. Novices were significantly more likely to rate a low likelihood of cancer when viewing infectious laryngitis compared to more experienced groups ( P < .001). There was no difference in likelihood of cancer rating among groups for the remaining images. Conclusions: There was no significant difference in gaze targets among participants of different experience levels evaluating vocal cord pathology. Symmetric appearance of vocal cord lesions may explain differences seen in likelihood of cancer rating among groups. Future studies with larger sample sizes will better elucidate gaze targets that lead to accurate diagnosis of vocal cord pathology.
Influence of avascular necrosis of the femoral head on hip prosthesis integration: a radiological analysis
Authors: Woerner Michael , Koehn Anna , Morris Patrick , Weber Markus , Renkawitz Tobias , Grifka Joachim , Craiovan Benjamin 
Published: June 2023

Background Avascular osteonecrosis of the femoral head (AVN) often results in total hip arthroplasty (THA). The cause for increased THA revision rates among patients with AVN is not yet fully understood. Purpose To perform a comparative radiological analysis of implant integration between patients with AVN and osteoarthritis (OA). Material and Methods After a matched pair analysis of 58 patients, 30 received THA due to OA, 28 due to AVN. X-ray images were evaluated after one week (“baseline”) and on average 37.58 months postoperatively (“endline”). The prosthesis was grouped into 10 regions of interest (ROI): seven femoral and three acetabular. Incidence, width, and extent of “radiolucent lines” were measured within each zone. Results Between baseline and endline, width and extent progressed more noticeably in all femoral and acetabular zones among patients with AVN. In femoral ROI 1, the width increased in 40% of AVN cases compared to 6.7% of OA cases. For acetabular ROI 3, the width increased in 26.7% of AVN cases compared to no perceived changes in the OA group. No signs of prosthetic loosening were found in the AVN group. Conclusion The increase of width and extent of radiolucent lines over time in patients with AVN could be a sign of lack of osteointegration. However, prosthetic loosening in absence of clinical symptoms cannot be deduced from radiological findings after medium-term postoperative follow-up. Further long-term studies are required to monitor how radiolucent lines develop in respect to long-term implant loosening. Dependent on bone quality, individually adapted reaming and broaching of the implant site are recommended.
Ten-Year Survivorship, Outcomes, and Sports Participation in Athletes After Primary Hip Arthroscopy for Femoroacetabular Impingement Syndrome
Authors: Domb Benjamin G. , Annin Shawn , Monahan Peter F. , Lee Michael S. , Jimenez Andrew E. , Maldonado David R. 
Published: June 2023

Background: Hip arthroscopy is an effective treatment tool for athletes with femoroacetabular impingement (FAI) syndrome. However, long-term data are scarce. Purpose: To assess survivorship, minimum 10-year patient-reported outcome measures (PROMs), and sports participation after primary hip arthroscopy for FAI syndrome in athletes and to perform a propensity-matched comparison between patients undergoing labral debridement and labral repair. Study Design: Cohort study; Level of evidence, 3. Methods: Athletes who underwent hip arthroscopy for FAI syndrome between February 2008 and December 2010 were eligible. Exclusion criteria were other ipsilateral hip condition, Tönnis grade ≥2, or no baseline PROMs. Survivorship was defined as no conversion to total hip arthroplasty. The Patient Acceptable Symptom State (PASS), minimal clinically important difference (MCID), maximum outcome improvement (MOI) satisfaction threshold, and sports participation were reported. A propensity-matched comparison between labral debridement and labral repair was performed. Two additional propensity-matched subanalyses were performed for capsular management and cartilage damage. Results: In total, 189 hips (177 patients) were included. The mean ± SD follow-up was 127.2 ± 6.0 months. Survivorship was 85.7%. Significant improvement in all PROMs was reported ( P < .001). A total of 46 athletes with labral repair were propensity matched to 46 athletes with labral debridement. This subanalysis demonstrated significant and comparable improvement in all PROMs at minimum 10-year follow-up ( P < .001). For the labral repair group, the PASS achievement rates were 88.9% for the modified Harris Hip Score (mHHS) and 80% for the Hip Outcome Score–Sport Specific Subscale (HOS-SSS); the MCID achievement rates were 80.6% for the mHHS and 84% for HOS-SSS; and for the MOI satisfaction threshold, rates were 77.8%, 80.6%, and 55.6% for the mHHS, Nonarthritic Hip Score, and visual analog scale, respectively. For the labral debridement group, the PASS achievement rates were 85.3% for the mHHS and 70.4% for the HOS-SSS; the MCID achievement rates were 81.8% for the mHHS and 74.1% for HOS-SSS; and for the MOI satisfaction threshold, rates were 72.7%, 81.8%, and 66.7% for the mHHS, Nonarthritic Hip Score, and visual analog scale. Total hip arthroplasty conversions occurred significantly sooner with labral debridement than labral repair ( P = .048). Age was identified as a significant predictor of achieving the PASS. Conclusion: Primary hip arthroscopy for FAI syndrome in athletes results in 85.7% survivorship and sustained PROM improvement at a minimum 10-year follow-up. A significant time delay to total hip arthroplasty conversion at 10-year follow-up was reported with labral repair over debridement, although this should be interpreted with caution, as the total number of conversions was small.
Culturally Adapted Cognitive Behaviour Therapy (CaCBT) to Improve Community Mental Health Services for Canadians of South Asian Origin: A Qualitative Study
Authors: Naeem Farooq , Khan Nagina , Sohani Nazia , Safa Farhana , Masud Mehreen , Ahmed Sarah , Thandi Gary , Mutta Baldev , Kasaam Azaad , Tello Kamlesh , Husain Muhammad Ishrat , Husain Muhammad Omair , Kidd Sean A. , McKenzie Kwame 
Published: June 2023

Background South Asian (SA) Canadians are disproportionately affected by higher rates of mood and anxiety disorders. SA Canadians with depression report significant barriers to accessing mental health care and the highest proportion of unmet mental health needs. The Mental Health Commission of Canada (MHCC) advocates for culturally and linguistically relevant services for SA Canadians. Culturally adapted cognitive behavior therapy (CaCBT) has shown to be more effective than standard cognitive behavior therapy (CBT). Adapting CBT for the growing SA population in Canada will ensure equitable access to effective, culturally-appropriate mental health interventions. Method The study used a qualitative design to elicit stakeholder consultation via in-depth interviews. This study is reported using the criteria included in Consolidated Criteria for Reporting Qualitative Studies (COREQ). The analysis follows an ethnographic approach and was informed by the principles of emergent design. Results Five themes were identified from the analysis, (i) Awareness and preparation: factors that impact the individual's understanding of therapy and mental illness. (ii) Access and provision: SA Canadians’ perception of barriers, facilitators, and access to treatment. (iii) Assessment and engagement: experiences of receiving helpful treatment. (iv) Adjustments to therapy: modifications and suggestions to standard CBT. (v) Ideology and ambiguity: racism, immigration, discrimination, and other socio-political factors. Conclusions Mainstream mental health services need to be culturally appropriate to better serve SA Canadians experiencing depression and anxiety. Services must understand the family dynamics, cultural values and socio-political factors that impact SA Canadians to reduce attrition rates in therapy.
The Ability of Self-Report Methods to Accurately Diagnose Attention Deficit Hyperactivity Disorder: A Systematic Review
Authors: Harrison Allyson G. , Edwards Melanie J. 
Published: June 2023

Objective: To identify and analyze all studies validating rating scales or interview-based screeners commonly used to evaluate ADHD in adults. Method: A systematic literature search identified all studies providing diagnostic accuracy statistics, including sensitivity and specificity, supplemented by relevant articles or test manuals referenced in reviewed manuscripts. Results: Only 20 published studies or manuals provided data regarding sensitivity and specificity when tasked with differentiating those with and without ADHD. While all screening measures have excellent ability to correctly classify non-ADHD individuals (with negative predictive values exceeding 96%), false positive rates were high. At best, positive predictive values in clinical samples reached 61%, but most fell below 20%. Conclusion: Clinicians cannot rely on scales alone to diagnose ADHD and must undertake more rigorous evaluation of clients who screen positive. Furthermore, relevant classification statistics must be included in publications to help clinicians make statistically defensible decisions. Otherwise, clinicians risk inappropriately diagnosing ADHD.
Long-Term Outcomes of Drug-Eluting Stent Implantation for Patients With Atherosclerotic Erectile Dysfunction not Responding to PDE-5-Inhibitors
Authors: Mohan Vignes , Schönhofen Jan , Hoppe Hanno , Schumacher Martin , Keo Hak-Hong , Bechir Markus , Kalka Christoph , Burkhard RN Madlen , Diehm Nicolas 
Published: June 2023

Purpose: Endovascular therapy of erection-related arteries was shown to be a promising treatment option for patients with severe erectile dysfunction. Purpose of this study was to assess the longer-term safety and clinical success rate of endovascular revascularization of erection-related arteries with the Angiolite BTK stent in patients with arteriogenic erectile dysfunction. Materials and Methods: A total of 147 consecutive men (63.5±9.3 years) with erectile dysfunction due to 345 atherosclerotic lesions underwent endovascular revascularization. Patients received an International Index of Erectile Function (IIEF)-15 questionnaire at 30.3±7.2 months (follow-up [FU] period no less than 18 months) after stenting. An improvement by 4 points in the erectile function domain consisting of 6 questions (IIEF-6) was defined as minimal clinically important difference (MCID). Results: Technical success was achieved in 99% of lesions. One major adverse event occurred after endovascular revascularization. Sixty-eight (46%) patients completed their latest FU at least 18 months following the last intervention. Minimal clinically important difference was achieved in 54% (37/68) of patients. Conclusions: In patients with arteriogenic erectile dysfunction not responding to phosphodiesterase-5-inhibitors (PDE-5-Is), endovascular therapy with a novel thin-strut sirolimus-eluting stent is a safe and effective treatment option during short- and longer-term FU. Clinical Impact Patients with severe erectile dysfunction profit greatly from endovascular therapy of erection-related arteries. Stable clinical outcomes are seen beyond a 1-year timeframe. It is proven that, the drug-eluting stent therapy for atherosclerotic ED in patients who have not responded to PDE-5-I therapy is safe and effective during longer-term follow-up.
Predictive prognostic factors in patients with proximal humeral fracture treated with reverse shoulder arthroplasty
Authors: Canbolat Nur , Bayram Serkan , Gökçeoğlu Yaşar Samet , Tezgel Okan , Kapicioğlu Mehmet , Erşen Ali , Bilsel Kerem , Büget Mehmet İlke 
Published: June 2023

Background We aimed to evaluate the predictive determitants in patients with PHF who were treated with reverse shoulder arthroplasty (RSA) by evaluating the patient characteristics and comorbidities and extensive preoperative laboratory parameters. Methods With examining the records of elderly patients (over 65 years old) with PHF, who were admitted to our emergency department between 2009 and 2020. For evaluation of the survival, we performed Kaplan-Meirer statistical anaylses. A Cox algorithms (uni and multivariate) were applied to recognize factors (including clinical and laboratory parameters) which are associated with survival. Results Sixty-three females and 17 males were included with a mean of 73.5 ± 7.4 years of age. Nineteen (23.83%) patients had decreased after the surgery, with a mean survival of 47.5 ± 32.7 months. There were 61 (76.3%) surviving patients with a mean survival of 67.4 ± 35.4 months. Survival rates in the first 6 months (n: 2 patients), first year (n: 3 patients), and second year (n: 6 patients) after surgery were 97.5%, 96.3%, and 92.3%, respectively. Conclusion The age and preoperative hemoglobin level were independently related with poor survival in patients with PHF. Level of Evidence Level III Retrospective Cohort, Prognosis Study
Effect and Mechanism of Harmine on Echinococcosis Based on Network Pharmacology
Authors: Chen Bei , Zhao Jun , Teng Liang , Buhuliqianmu Yimaierjiang , Xu Zhaohui , Gong Yuehong , Gao Huijing 
Published: June 2023

Objective The aim of this research was to explore the effects on echinococcosis of harmine, an active ingredient of Peganum harmala. Methods The gene targets were screened out by use of an online database. STRING was exploited to build a protein interaction network model, DAVID to carry out gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and AutoDockTools for molecular docking. All mice were randomly divided into 3 groups: a model group, a normal group, and a harmine group. Blood indicators were detected and histological analysis was carried out. NCTC-1469 was treated with either harmine or control. Gene expression was evaluated by Western blot. Results Network pharmacological analysis concluded that 6 gene targets (HLA-B, HLA-DQB1, IL-6, tumor necrosis factor [TNF], HLA-A, and F3) might act as the major targets in the treatment of echinococcosis with harmine. GO function and KEGG pathway enrichment analyses showed that harmine might treat echinococcosis mainly by regulating the immune response. Molecular docking confirmed that harmine docked well to the targets and that the interactions were reliable. Harmine could regulate the content of inflammatory factors to modulate the immune response of mice, but caused liver damage. Pathological histology analysis confirmed that harmine had great suppressive efficacy against echinococcosis infection. However, the use of harmine would have a certain negative effect on the spleen of mice. The contents of HLA-B, HLA-DQB1, TNF, HLA-A, and F3 were observably enhanced, while Interleukin-6 was reduced in mouse liver tissue and cells after harmine treatment. As forecast by network pharmacology, harmine exerted antiechinococcosis effects by multiple targets and pathways. Finally, harmine treatment might regulate the Th17/Treg balance in mice with echinococcosis infection. Conclusions Harmine displayed great suppressive efficacy against echinococcosis infection by regulating the immune response. These findings suggest that harmine could be a potential therapeutic agent for echinococcosis management by targeting specific gene targets.
Pain symptoms, sexual and mental health at the time of endometriosis diagnosis
Authors: Netzl Johanna , Gusy Burkhard , Voigt Barbara , Sehouli Jalid , Mechsner Sylvia 
Published: June 2023

Introduction: We aimed at examining the physical symptoms, sexual and mental health of individuals at the time of receiving the diagnosis of endometriosis. Our goal was to gain a better understanding of their needs at this specific time. Methods: Fifty cis women who had received the diagnosis of endometriosis within the last 4 weeks were examined in this cross-sectional study. Participants completed a comprehensive questionnaire and the Childhood Trauma Questionnaire (CTQ). The Diagnostic Interview for Mental Disorders (DIPS) was performed for each subject for the assessment of mental disorders according to DSM-5 criteria and to screen for sexual dysfunctions. Results: Participants were M = 27.02 ± 5.72 years old. More than 90% reported dysmenorrhea (93.9%), one fifth chronic pelvic pain (22.0%) and more than three quarters painful sexual intercourse (84.0%). More than 40% met the criteria of a current mental disorder. 21 participants reported a sexual dysfunction (42.0%) and 21 reported childhood maltreatment (42.9%). A current mental disorder was associated with impaired sexual functioning: Participants with a current mental disorder reported higher pain intensity scores during sexual intercourse and were more likely to report a current sexual dysfunction. Conclusion: Our results highlight the need for earlier diagnoses of endometriosis to prevent the progression of pelvic pain and for integrating mental and sexual health support in endometriosis care from the beginning. A biopsychosocial model of mental health in endometriosis is proposed.