bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Anterior Cervical Discectomy Fusion Combined with Lateral Mass Screw and with Cervical Pedicle Screw Fixation Surgery under O‐Arm Navigation for Single‐Stage Management of Severe Lower Cervical Fracture Dislocation
Authors: Tang Yingchuang , Li Hanwen , Zhang Shangwu , Liu Hao , Zhang Junxin , Yang Huilin , Zhang Kai , Wang Genlin , Chen Kangwu 
Published: September 2023

ObjectiveThe incidence of severe lower cervical fractures and dislocations due to trauma has increased significantly, and the optimal treatment remains controversial. This study compares the safety and efficacy of anterior cervical discectomy fusion (ACDF) combined with lateral mass screw (LMS) and with cervical pedicle screw (CPS) fixation surgery under O‐arm navigation as single‐stage treatments of severe lower cervical fracture dislocations.MethodsData from 48 patients who underwent ACDF + CPS (Group A) or ACDF + LMS (Group B) for severe lower cervical fracture dislocation between January 2016 and September 2020 were retrospectively reviewed. Groups A and B comprised 25 and 23 cases, respectively. Clinical parameters, such as operative time, intraoperative blood loss, number of fixed segments, posterior incision length, operative complications, and hospitalization days were recorded. Preoperatively and postoperatively, the sub‐axial injury classification (SLIC) score, the American Spinal Injury Association (ASIA) impairment scale, and the Japanese Orthopaedic Association (JOA) score were recorded and analyzed using Student's t‐test.ResultsThe SLIC scores were 7.1 ± 1.2 and 7.5 ± 1.1, ASIA were 1.5 ± 0.6 and 1.2 ± 0.6, JOA score improvements were 3.2 ± 2.4 and 3.0 ± 2.1, operative times were 282.1 ± 91.7 and 266.5 ± 88.2 min, intraoperative blood losses were 437.8 ± 118.5 and 418.7 ± 104.2 mL, fixed segments were 2.8 ± 0.7 and 4.8 ± 1.1, and lengths of posterior incisions were 12.7 ± 2.8 and 13.8 ± 3.2 cm in Groups A and B, respectively. There was no significant difference between the two groups in the operative time, intraoperative blood loss, incision length, and postoperative recovery; however, group A had more fixed segments. At the final follow‐up, no intraoperative or postoperative complications directly caused by the implant were present. Throughout the follow‐up, all cases showed recovery and progressive improvement.ConclusionBoth ACDF + LMS and ACDF + CPS under O‐arm navigation can safely and effectively restore cervical vertebral sequence, fully release spinal canal compression, and promote patients’ neurological recovery. Thus, both are effective treatments for severe lower cervical fracture dislocations. However, compared to LMS, CPS under O‐arm navigation has shorter fixed segments and induces less trauma.
Improved donor lung size matching by estimation of lung volumes based on chest X‐ray measurements
Authors: Roach David J. , Szugye Nick A. , Moore Ryan A. , Hossain Md Monir , Morales David L. S. , Hayes Don , Towe Christopher T. , Zafar Farhan , Woods Jason C. 
Published: September 2023

AbstractRationaleOrgan size matching is an important determinant of successful allocation and outcomes in lung transplantation. While computed tomography (CT) is the gold standard, it is rarely used in an organ‐donor context, and chest X‐ray (CXR) may offer a practical and accurate solution in estimating lung volumes for donor and recipient size matching. We compared CXR lung measurements to CT‐measured lung volumes and traditional estimates of lung volume in the same subjects.MethodsOur retrospective study analyzed clinically obtained CXR and CT lung images of 250 subjects without evidence of lung disease (mean age 9.9 ± 7.8 years; 129 M/121F). From CT, each lung was semi‐automatically segmented and total lung volumes were quantified. From anterior–posterior CXR view, each lung was manually segmented and areas were measured. Lung lengths from the apices to the mid‐basal regions of each lung were measured from CXR. Quantified CT lung volumes were compared to the corresponding CXR lung lengths, CXR lung areas, height, weight, and predicted total lung capacity (pTLC).ResultsThere are strong and significant correlations between CT volumes and CXR lung areas in the right lung (R2 = .89, p < .0001), left lung (R2 = .87, p < .0001), and combined lungs (R2 = .89, p < .0001). Similar correlations were seen between CT volumes and CXR measured lung lengths in the right lung (R2 = .79, p < .0001) and left lung (R2 = .81, p < .0001). This correlation between anatomical lung volume (CT) and CXR was stronger than lung‐volume correlation to height (R2 = .66, p < .0001), weight (R2 = .43, p < .0001), or pTLC (R2 = .66, p < .0001).ConclusionCXR measures correlate much more strongly with true lung volumes than height, weight, or pTLC. The ability to obtain efficient and more accurate lung volume via CXR has the potential to change our current listing practices of using height as a surrogate for lung size, with a case example provided.
Predictive role of neutrophil‐percentage‐to‐albumin, neutrophil‐to‐lymphocyte and eosinophil‐to‐lymphocyte ratios for mortality in patients with COPD: Evidence from NHANES 2011–2018
Authors: Lan Chou‐Chin , Su Wen‐Lin , Yang Mei‐Chen , Chen Sin‐Yi , Wu Yao‐Kuang 
Published: September 2023

AbstractBackground and ObjectiveThis study evaluated the predictive roles of hematologic inflammatory biomarkers including neutrophil‐percentage‐to‐albumin ratio (NPAR), neutrophil‐to‐lymphocyte ratio (NLR) and eosinophil‐to‐lymphocyte ratio (ELR) for mortality in community‐dwelling individuals with chronic obstructive pulmonary disease (COPD).MethodsThis longitudinal study extracted data of adults 40–79 years who had physician‐diagnosed COPD from the United States (US) National Health and Nutrition Examination Survey (NHANES) 1999–2018. Cox regressions determined the associations between NPAR, NLR, ELR and their components, with all‐cause mortality, cardiovascular disease (CVD) mortality and mortality from chronic lower respiratory disease (CLRD). Receiver operating characteristic (ROC) curve analysis estimated the predictive performances of these biomarkers for 5‐year all‐cause mortality.ResultsData of 1158 subjects were analysed. After adjustment, higher NPAR was significantly associated with increased all‐cause and CVD mortality, and mortality from CLRD (adjusted hazard ratio [aHR] = 1.14, 1.15 and 1.16). Higher NLR was associated with an increased all‐cause and CVD mortality (aHR = 1.16 and 1.29). Higher neutrophil was associated with increased all‐cause mortality and mortality from CLRD (aHR = 1.13 and 1.34). Albumin was associated with decreased all‐cause and CVD mortality (aHR = 0.91 and 0.86). ELR, eosinophil or lymphocyte was not significantly associated with either mortality outcomes. Adjusted AUC of NPAR and NLR in predicting 5‐year all‐cause mortality were 0.808 (95% CI: 0.722–0.845) and 0.799 (95% CI: 0.763–0.835), respectively.ConclusionIn community‐dwelling US adults with COPD, increased NPAR and NLR are associated with mortality risks. NPAR outperforms the other hematologic inflammatory biomarkers in predicting 5‐year all‐cause mortality.
Recent insights into mechanisms of hypoxia‐induced vasodilatation in the human brain
Authors: Carr Jay M. J. R. , Hoiland Ryan L. , Fernandes Igor A. , Schrage William G. , Ainslie Philip N. 
Published: September 2023

AbstractThe cerebral vasculature manages oxygen delivery by adjusting arterial blood in‐flow in the face of reductions in oxygen availability. Hypoxic cerebral vasodilatation, and the associated hypoxic cerebral blood flow reactivity, involve many vascular, erythrocytic and cerebral tissue mechanisms that mediate elevations in cerebral blood flow via micro‐ and macrovascular dilatation. This contemporary review focuses on in vivo human work – with reference to seminal preclinical work where necessary – on hypoxic cerebrovascular reactivity, particularly where recent advancements have been made. We provide updates with the following information: in humans, hypoxic cerebral vasodilatation is partially mediated via a – likely non‐obligatory – combination of: (1) nitric oxide synthases, (2) deoxygenation‐coupled S‐nitrosothiols, (3) potassium channel‐related vascular smooth muscle hyperpolarization, and (4) prostaglandin mechanisms with some contribution from an interrelationship with reactive oxygen species. And finally, we discuss the fact that, due to the engagement of deoxyhaemoglobin‐related mechanisms, reductions in O2 content via haemoglobin per se seem to account for ∼50% of that seen with hypoxic cerebral vasodilatation during hypoxaemia. We further highlight the issue that methodological impediments challenge the complete elucidation of hypoxic cerebral reactivity mechanisms in vivo in healthy humans. Future research is needed to confirm recent advancements and to reconcile human and animal findings. Further investigations are also required to extend these findings to address questions of sex‐, heredity‐, age‐, and disease‐related differences. The final step is to then ultimately translate understanding of these mechanisms into actionable, targetable pathways for the prevention and treatment of cerebral vascular dysfunction and cerebral hypoxic brain injury.
image
Development of Physical-Chemical Surrogate Models and Skeletal Mechanisms for the Combustion Simulation of Several Jet Fuels
Authors: Yu Jin , Guo Fanjun , Deng Tao , Liu Ping , Yu Jia-Jia 
Published: September 2023

Abstract
The physical–chemical surrogate models for S-8, Jet-A, and RP-3 fuels to capture their physical and kinetics properties have been developed in this study. n-dodecane (nC12H26), 2,5-dimethylhexane (C8H18-25), and toluene (C6H5CH3) were chosen as candidate surrogate components and formulated by the function group based surrogate fuel methodology. Some important physical properties and spray characteristics for S-8, Jet-A, and RP-3 surrogate models were validated. The results indicate that present surrogate models can well emulate various physical properties to accurately reproduce the spray characteristics. Then, a minimal and high-precision surrogate skeletal mechanism that can be suitable for computational fluid dynamics (CFD) simulations was developed and validated against some fundamental combustion experiments for each surrogate component. Furthermore, the performances of surrogate models that contain the surrogate formulation and associated skeletal mechanisms were validated against the experimental data on ignition delay times (IDTs), species concentration profiles, and laminar flame speeds (Su0) in a wide range of conditions. Finally, the surrogate fuels were used to combustion CFD simulations to model the spray combustion process in a constant volume combustion chamber. It can be seen that the agreements between the simulation and experiment in fundamental and spray combustion characteristics are reasonably good, which proves that present surrogate models are accurate and robust to be applied in CFD simulations.
Reducing the Energy Penalty of Retrofit Decarbonization in Combined Cycle Power Plants
Authors: Ravelli Silvia 
Published: September 2023

Abstract
This study is a continuation of previous work aimed at elucidating the effect of hydrogen-cofiring and exhaust gas recirculation (EGR) on combined cycle (CC) performance. The thermodynamic analysis was expanded to include postcombustion capture (PCC) by means of mono-ethanolamine (MEA). Attention was paid to net power output and thermal efficiency. Part-load operation of the CC without carbon capture was taken as a reference. Decarbonization solutions, in ascending order of complexity, included the following: (1) adding a PCC unit; (2) combining EGR with PCC, so as to exploit the increase in the flue gas CO2 concentration while reducing the exhaust gas flow delivered to the absorber; (3) including hydrogen cofiring at the largest capability dictated by the gas turbine (GT) combustion system, with the opportunity to explore a wider range of EGR rates, while still relying on PCC of the residual CO2 in flue gas, before discharge into the environment. Scenarios were first discussed under the same GT load for consistency with the published literature, thus enabling the validation of the modeling procedure. Then, CC net power production was assumed as the basis of comparison. The third solution was found to be the most promising thus minimizing both the energy penalty due to carbon capture and CO2 emission intensity (EI).
L-arabinose affects the growth, biofilm formation, motility, c-di-GMP metabolism, and global gene expression of
Vibrio parahaemolyticus
Authors: Zhang Miaomiao , Luo Xi , Li Xue , Zhang Tingting , Wu Fei , Li Min , Lu Renfei , Zhang Yiquan 
Published: September 2023

ABSTRACT

The L-arabinose inducible pBAD vectors are commonly used to turn on and off the expression of specific genes in bacteria. The utilization of certain carbohydrates can influence bacterial growth, virulence factor production, and biofilm formation.
Vibrio parahaemolyticus
, the causative agent of seafood-associated gastroenteritis, can grow in media with L-arabinose as the sole carbon source. However, the effects of L-arabinose on
V. parahaemolyticus
physiology have not been investigated. In this study, we show that the growth rate, biofilm formation capacity, capsular polysaccharide production, motility, and c-di-GMP production of
V. parahaemolyticus
are negatively affected by L-arabinose. RNA-seq data revealed significant changes in the expression levels of 752 genes, accounting for approximately 15.6% of
V. parahaemolyticus
genes in the presence of L-arabinose. The affected genes included those associated with L-arabinose utilization, major virulence genes, known key biofilm-related genes, and numerous regulatory genes. In the majority of type III secretion system, two genes were upregulated in the presence of L-arabinose, whereas in those of type VI secretion system, two genes were downregulated. Ten putative c-di-GMP metabolism-associated genes were also significantly differentially expressed, which may account for the reduced c-di-GMP levels in the presence of L-arabinose. Most importantly, almost 40 putative regulators were significantly differentially expressed due to the induction by L-arabinose, indicating that the utilization of L-arabinose is strictly regulated by regulatory networks in
V. parahaemolyticus
. The findings increase the understanding of how L-arabinose affects the physiology of
V. parahaemolyticus
. Researchers should use caution when considering the use of L-arabinose inducible pBAD vectors in
V. parahaemolyticus
.

IMPORTANCE

The data in this study show that L-arabinose negatively affects the growth rate, biofilm formation, capsular polysaccharide production, motility, and c-di-GMP production of
V. parahaemolyticus
. The data also clarify the gene expression profiles of the bacterium in the presence of L-arabinose. Significantly differentially expressed genes in response to L-arabinose were involved in multiple cellular pathways, including L-arabinose utilization, virulence factor production, biofilm formation, motility, adaptation, and regulation. The collective findings indicate the significant impact of L-arabinose on the physiology of
V. parahaemolyticus
. There may be similar effects on other species of bacteria. Necessary controls should be established when pBAD vectors must be used for ectopic gene expression.
Virus hijacking of host epigenetic machinery to impair immune response
Authors: Locatelli Maëlle , Faure-Dupuy Suzanne 
Published: September 2023

ABSTRACT
Epigenetic modifications, such as DNA hypermethylation, histone acetylation/methylation, or nucleosome positioning, result in differential gene expression. These modifications can have an impact on various pathways, including host antiviral immune responses. In this review, we summarize the current understanding of epigenetic modifications induced by viruses to counteract host antiviral immune responses, which are crucial for establishing and maintaining infection of viruses. Finally, we provide insights into the potential use of epigenetic modulators in combating viral infections and virus-induced diseases.
Complete genome sequence of a
Staphylococcus condimenti
isolated from a port catheter-associated bloodstream infection
Authors: Berneking Laura , Büttner Henning , Qi Minyue , Günther Thomas , Lehnhoff Daniel , Both Anna , Christner Martin , Wolters Manuel , Alawi Malik , Aepfelbacher Martin , Rohde Holger 
Published: September 2023

ABSTRACT

Here, we describe the complete genome sequence of a
Staphylococcus condimenti
blood culture isolate from a catheter-related bloodstream infection in a male patient.
Topology of nonlinearly charged black hole chemistry via massive gravity
Authors: Zhang Meng-Yao , Chen Hao , Hassanabadi Hassan , Long Zheng-Wen , Yang Hui 
Published: September 2023

AbstractThe classification of critical points of charged topological black holes (TBHs) in anti-de Sitter spacetime (AdS) under the Power Maxwell Invariant (PMI)-massive gravity is accomplished within the framework of black hole chemistry (BHC). Considering the grand canonical ensemble (GCE), we show that $$d=4$$

d
=
4

black hole have only one topological class, whereas $$d\ge 5$$

d
≥
5

black holes belong to two different topology classes. Furthermore, the conventional critical point characterized by negative topological charge coincides with the maximum extreme point of temperature; and the novel critical point featuring opposite topological charge corresponds to the minimum extreme point of temperature. With increasing pressure, new phases emerge at the novel critical point while disappear from the conventional one. Moreover, a atypical van der Waals (vdW) behavior is found in $$d\ge 6$$

d
≥
6

dimensions, and the anomaly disappears at the traditional critical point. In the limit of nonlinearity parameter $$s\rightarrow 1$$

s
→
1

, different topology classes are only obtained in the GCE and they may not exist within the canonical ensemble. With the absence of electric potential $$\Phi $$
Φ
, the neutral TBHs share the same topological classification results as the charged TBHs in the GCE of Maxwell-massive gravity.
Cerebral Salt Wasting Syndrome pada Pasien dengan Infark Serebri : Sebuah Laporan Kasus
Authors: Hapsari Aulia , Prakoso Budi 
Published: September 2023

Pendahuluan: Hiponatremia merupakan kondisi yang sering terjadi di rumah sakit, pada pasien dengan gangguan sistem saraf pusat sering menyebabkan hiponatremia oleh SIADH (Syndrome Inappropriate Antidiuretic Hormone) dan CSWS (cerebral salt wasting syndrome).
Laporan Kasus Wanita usia 71 tahun datang dengan keluhan tidak sadar 12 jam SMRS, Riwayat jatuh dan kepala terbentur lantai 3 hari SMRS. Pasien memiliki Riwayat hipertensi dan mengkonsumsi amlodipine 5 mg. Pasien tampak dehidrasi dan didapatkan produksi urin 3000cc/hari dengan hiponatremia berat. Pasien didiagnosis dengan CSWS dan mendapatkan hipertonik salin serta steroid. Pasien berespon positif terhadap terapi yang diberikan ditandai dengan meningkatnya kadar sodium serum secara berkala dan pulihnya kesadaran.
Diskusi: CSWS adalah kondisi hiponatremia dan dehidrasi yang disebabkan cedera kepala,infark serebri,dan gangguan neurologi lainya. Penyebab CSWS cenderung dipengaruhi oleh peptide natriuretic, peptida ini tidak hanya dikeluarkan pada kondisi gagal jantung namun pada kondisi kerusakan saraf pusat.
Kesimpulan: Pada laporan kasus ini, Wanita usia 71 tahun yang terdiagnosis CSWS dikarenakan infark serebri berespon positif dengan terapi hipertonik saline dan steroid. Penyebab utama hiponatremi yaitu CSWS dan SIADH yang didapatkan dari anamnesis hingga pemeriksaan penunjang agar dapat memberikan terapi yang holistik dan komprehensif.
Recorrências locais de tumores de glândulas salivares em uma população brasileira
Authors: Lucena Maria Eduarda de Arruda , Almeida Hittalo Carlos Rodrigues de , Silva Leorik Pereira da , Silveira Márcia Maria Fonseca da , Sobral Ana Paula Veras 
Published: September 2023

Objetivo: Identificar a presença de recidiva após o ato cirúrgico de pacientes diagnosticados com tumor de glândula salivar. Métodos: Os dados foram coletados no Hospital de Câncer de Pernambuco, Recife, Brasil, através de um formulário padrão com base nos prontuários clínicos. Foram coletadas informações sobre idade, sexo, tipo de tumor de glândula salivar, recidiva local, estágio, local primário e tipo de tratamento. Os dados foram descritivos e analisados com nível de significância de 5% (p < 0,05). Resultados: Dos 55 prontuários que fizeram parte da amostra do estudo, 51% correspondem ao sexo masculino. A média de idade geral foi de 55 anos, com a faixa etária variando entre 13 e 90 anos. O adenocarcinoma (SOE) foi o mais prevalente (n = 17), seguido do carcinoma adenoide cístico (CAC) (n = 14; 25,5%). Dentre todos os sítios, o mais comum foi a glândula parótida (n = 29; 53%). 61,8% (n = 34) dos pacientes não apresentaram metástase à distância. Entretanto, 38,18% (n = 21) apresentaram, sendo 14,55% (n = 8) com metástase em osso. 34,55% (n = 19) dos pacientes tiveram recidiva com apenas 1 ano após o diagnóstico. A neoplasia com maior taxa de recidiva foi o SOE, apresentando 30,91% (n = 17); o CAC foi o segundo maior com 25,45% (n = 14). Conclusão: O sexo masculino perfez a maioria dos casos; houve um predomínio de acometimento na glândula parótida; as neoplasias mais frequentes foram o SOE e o CAC; metástase à distância ocorreu em 38,18% (n = 21), sendo o osso o local mais acometido; a cirurgia com radioterapia adjuvante (n = 15) foi o tratamento de eleição.
Feasibility of Simultaneous Quantification of Myocardial and Renal Perfusion With Cardiac Positron Emission Tomography
Authors: Brown Jenifer M. , Park Mi-Ae , Kijewski Marie Foley , Weber Brittany N. , Yang Yihe , Martell Laurel , Perillo Anna , Barrett Leanne , Parks Sean , Hainer Jon , Dorbala Sharmila , Blankstein Ron , Di Carli Marcelo F. 
Published: September 2023

BACKGROUND:
Given the central importance of cardiorenal interactions, mechanistic tools for evaluating cardiorenal physiology are needed. In the heart and kidneys, shared pathways of neurohormonal activation, hypertension, and vascular and interstitial fibrosis implicate the relevance of systemic vascular health. The availability of a long axial field of view positron emission tomography (PET)/computed tomography (CT) system enables simultaneous evaluation of cardiac and renal blood flow.

METHODS:

This study evaluated the feasibility of quantification of renal blood flow using data acquired during routine, clinically indicated
13
N-ammonia myocardial perfusion PET/CT. Dynamic PET image data were used to calculate renal blood flow. Reproducibility was assessed by the intraclass correlation coefficient among 3 independent readers. PET-derived renal blood flow was correlated with imaging and clinical parameters in the overall cohort and with histopathology in a small companion study of patients with a native kidney biopsy.

RESULTS:

Among 386 consecutive patients with myocardial perfusion PET/CT, 296 (76.7%) had evaluable images to quantify renal perfusion. PET quantification of renal blood flow was highly reproducible (intraclass correlation coefficient 0.98 [95% CI, 0.93–0.99]) and was correlated with the estimated glomerular filtration rate (
r
=0.64;
P
<0.001). Compared across vascular beds, resting renal blood flow was correlated with maximal stress myocardial blood flow and myocardial flow reserve (stress/rest myocardial blood flow), an integrated marker of endothelial health. In patients with kidney biopsy (n=12), resting PET renal blood flow was strongly negatively correlated with histological interstitial fibrosis (
r
=−0.85;
P
<0.001).

CONCLUSIONS:

Renal blood flow can be reliably measured from cardiac
13
N-ammonia PET/CT and allows for simultaneous assessment of myocardial and renal perfusion, opening a potential novel avenue to interrogate the mechanisms of emerging therapies with overlapping cardiac and renal benefits.