bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organizational context and inclusion: Perceptions of managers and people with disabilities
Authors: de Carvalho‐Freitas Maria Nivalda , de Oliveira Marcos Santos , Tette Raissa Pedrosa Gomes , Santos Joelma Cristina 
Published: June 2023

AbstractThe objective of this article was to identify factors in the organizational context that may influence the inclusion of people with disabilities at work. To this end, we conducted three investigations in Brazil. The first study was conducted with 120 managers from 11 organizations and aimed to verify whether actions to adjust both working conditions and work practices affect the perception of managers about the performance of people with disabilities, considering the heterogeneity of disabilities. The second study included 75 people with disabilities and aimed to verify whether job satisfaction with contextual factors, for example, salary, the possibility of skill development, integration, and growth opportunity could explain the affective commitment of these people toward the organizations. The third study, which investigated 169 people with disabilities, included other contextual factors such as social and organizational support to verify if they would affect the meaning these workers assign to their work. The results of Study 1 indicated that types of disabilities are effectively perceived in different ways by the managers and require differentiated actions. From the perspective of the workers with disabilities (Study 2), there is evidence that job satisfaction is related to affective commitment. In addition, it appears that social and organizational support factors (Study 3) are directly related to the perception of fairness, participation, and the reception of these people. Results and theoretical and practical implications will be discussed.
Associations between potentially inappropriate prescribing and increased number of medications with postdischarge health outcomes among geriatric rehabilitation inpatients: RESORT study
Authors: Mekonnen Alemayehu B. , Reijnierse Esmee M. , Soh Cheng Hwee , Lim Wen Kwang , Maier Andrea B. , Manias Elizabeth 
Published: June 2023

AimsOlder adults are vulnerable to medication‐related harm mainly due to high use of medications and inappropriate prescribing. This study aimed to investigate the associations between inappropriate prescribing and number of medications identified at discharge from geriatric rehabilitation with subsequent postdischarge health outcomes.MethodRESORT (REStORing health of acutely unwell adulTs) is an observational, longitudinal cohort study of geriatric rehabilitation inpatients. Potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs) were measured at acute admission, and at admission and discharge from geriatric rehabilitation, using Version 2 of the STOPP/START criteria.ResultsIn total, 1890 (mean age 82.6 ± 8.1 years, 56.3% female) were included. The use of at least 1 PIM or PPO at geriatric rehabilitation discharge was not associated with 30‐day and 90‐day readmission and 3‐month and 12‐month mortality. Central nervous system/psychotropics and fall risk PIMs were significantly associated with 30‐day hospital readmission (adjusted odds ratio [AOR] 1.53; 95% confidence interval [CI] 1.09–2.15), and cardiovascular PPOs with 12‐month mortality (AOR 1.34; 95% CI 1.00–1.78). Increased number of discharge medications was significantly associated with 30‐day (AOR 1.03; 95% CI 1.00–1.07) and 90‐day (AOR 1.06; 95% CI 1.03–1.09) hospital readmissions. The use and number of PPOs (including vaccine omissions) were associated with reduced independence in instrumental activities of daily living scores at 90‐days after geriatric rehabilitation discharge.ConclusionThe number of discharge medications, central nervous system/psychotropics and fall risk PIMs were significantly associated with readmission, and cardiovascular PPOs with mortality. Interventions are needed to improve appropriate prescribing in geriatric rehabilitation patients to prevent hospital readmission and mortality.
Outcomes of young adults (aged ≤ 40 years) with newly diagnosed multiple myeloma after up‐front autologous stem cell transplant
Authors: Pasvolsky Oren , Marcoux Curtis , Milton Denái R. , Tanner Mark R. , Bashir Qaiser , Srour Samer , Saini Neeraj , Lin Paul , Ramdial Jeremy , Nieto Yago , Lee Hans C. , Patel Krina K. , Kebriaei Partow , Tewari Priti , Crawford‐Suber Lindsay , Thomas Sheeba K. , Weber Donna M. , Orlowski Robert Z. , Shpall Elizabeth J. , Champlin Richard E. , Qazilbash Muzaffar H. 
Published: June 2023

SummaryMultiple myeloma (MM) primarily affects older patients. There are scarce data on the outcomes of young adults undergoing autologous transplantation (auto‐HCT). In this single‐centre analysis, we included 117 younger patients, with a median age of 37 years (range 22–40) at transplant. Seventeen (15%) patients had high‐risk cytogenetics. Before transplant, 10% of patients achieved ≥CR and 44% achieved ≥VGPR. At best post‐transplant response, 56% and 77% of patients achieved ≥CR and ≥VGPR respectively. With a median follow‐up for survivors of 72.6 months (range 0.9–238.0), median PFS and OS were 43.1 months (95% CI 31.2–65.0) and 146.6 months (95% CI 100.0–208.1) respectively. Patients who underwent auto‐HCT after 2010 had better median PFS (84.9 months vs. 28.2 months, p < 0.001) and OS (NR vs. 91.8 months, p < 0.001) compared with those transplanted earlier. In multi‐variate analysis, achieving ≥CR as best post‐transplant response was associated with improved PFS (HR [95% CI] 0.55 [0.32–0.95], p = 0.032), while achieving ≥VGPR was predictive of superior OS (0.32 [0.16–0.62], p < 0.001). Three patients (3%) developed a second primary malignancy. Younger MM patients had durable survival after auto‐HCT, which further improved after the availability of novel anti‐myeloma drugs in recent years. Depth of response following transplant remains a key predictor of survival.
Accessibility of social services and ICT‐based services for children with disabilities and their families
Authors: Rim Dahae , Shin Hyunsook , Jeon Hyejin 
Published: June 2023

AbstractChildren with disabilities and their families are often socially isolated. To integrate them into society, it is important to improve their access to services and encourage families to participate in society. It is effective to incorporate information and communication technology in providing information access and care services for children with disabilities and their families. Therefore, this study explores parental satisfaction with and demand for information and communication technology‐based care services for children with disabilities. This study used an explanatory sequential mixed method design. A total of 99 parents of children enrolled in two schools for special education or rehabilitation hospital participated in the study. Data were collected from parents through either a questionnaire survey or interviews. The study was conducted from 5 November to 5 December 2018. More than 50% of the participants found it inconvenient to search for services and reported below‐average satisfaction because of a lack of information and the results being inappropriate, abstract, difficult to understand, insufficient and scattered. More than 70% of the participants were dissatisfied with the services because of their high cost and the limited frequency of use. Participants expressed a need for information and communication technology‐based services to address these issues, including services to help the child's development, with low eligibility requirements and easy access to treatment that can enhance networks and services. Parents had high care burdens and difficulties accessing services for their children, which highlights the need for alternative services.
Naturalness and principle pluralism in conservation
Authors: Saltz David , Cohen Shlomo 
Published: June 2023

AbstractThe concept of naturalness in biodiversity conservation remains polysemic, hampering decision‐making. Although some conservationists claim ecosystem naturalness should be primarily determined by composition (integrity), others argue it should be determined by the extent of freedom from anthropogenic influence (autonomy). Problems arise when deciding how to treat affected ecosystems. Although the integrity school promotes benchmark‐based active restoration, the autonomy school advocates a hands‐off policy, making these 2 approaches contradictory. Moreover, expected global changes have promoted advocacy for ecosystem resilience, further complicating the debate. We argue that autonomy, integrity, and resilience are all morally valid. The conflict between them is contained by recognizing that full naturalness is an unattainable goal; restoration and rewilding processes are not an act of curation, but a contrary‐to‐duty obligation; principle pluralism can accommodate integrity, resilience, and autonomy as pro tanto principles in a case‐specific approach; and naturalness, as an overarching value, gives unity to the plurality of principles.
Migrants and imports: Evidence from Dutch firms
Authors: Erbahar Aksel , Gençosmanoğlu Ömer Tarık 
Published: June 2023

AbstractThis paper examines the effect of hiring migrants on firms' imports using a rich employer–employee dataset from the Netherlands for 2010–17. We use an instrumental variables strategy, and find that firms that employ migrants from a high‐income country are more likely to import from that country. Our benchmark specification indicates that a one standard deviation increase in the share of migrant workers from a certain country raises their employer's probability of importing from those workers' origin country by 6.6 percentage points, explaining half of the average probability of importing from a given country. This result is robust to a battery of sensitivity checks, and the effects are driven largely by migrants working in trade intermediaries that import final goods and inputs. Our results suggest that migrants help to erode informational barriers and enable their employers to source goods from abroad.
Association between childhood maltreatment and cortical folding in women with eating disorders
Authors: Cascino Giammarco , Canna Antonietta , Russo Andrea Gerardo , Monaco Francesco , Monteleone Alessio Maria , Ceres Rossella , Carfagno Marco , Di Salle Francesco , Monteleone Palmiero 
Published: June 2023

AbstractChildhood maltreatment (CM) is associated with distinct clinical and biological characteristics in people with eating disorders (EDs). The measurement of local gyrification index (lGI) may help to better characterize the impact of CM on cortical structure. Thus, the present study investigated the association of CM with lGI in women with EDs. Twenty‐six women with anorexia nervosa (AN) and 24 with bulimia nervosa (BN) underwent a 3T MRI scan. All participants filled in the Childhood Trauma Questionnaire. All neuroimaging data were processed by FreeSurfer. LGI maps underwent a general linear model to evaluate differences between groups with or without CM. People with AN and BN were merged together. Based on the Childhood Trauma Questionnaire cutoff scores, 24 participants were identified as maltreated and 26 as non‐maltreated. Maltreated people with EDs showed a significantly lower lGI in the left middle temporal gyrus compared with non‐maltreated people, whereas no differences emerged in the right hemisphere between groups. The present study showed that in people with EDs, CM is associated with reduced cortical folding in the left middle temporal gyrus, an area that could be involved in ED psychopathology. This finding corroborates the hypothesis of a ‘maltreated ecophenotype’, which argues that CM may allow to biologically, other than clinically, distinguish individuals with the same psychiatric disorder.
Advances in the understanding, detection and management of equine strangles
Authors: McLinden Luke A. , Freeman Sarah L. , Daly Janet , Blanchard Adam , Kemp‐Symonds Jeremy G. , Waller Andrew 
Published: June 2023

SummaryStreptococcus equisubspeciesequi(S. equi) is the causative organism of the upper respiratory disease of equids, strangles, characterised by pyrexia, lymphadenopathy and mucopurulent nasal discharge. Strangles was first reported over 750 years ago and continues to be of significance in equine populations across the globe. This review discusses howS. equihas adapted, the clinical manifestation of strangles, and how clinicians and caregivers can tackle the disease in the future.S. equievolved from the commensal, and occasionally opportunistic pathogen,Streptococcus equisubspecieszooepidemicusrefining its capabilities as it became host restricted. The success ofS. equican be attributed to its ability to cause both acute and persistent infection, the latter occurring in about 10% of those infected. In this carrier state,S. equipersists in the guttural pouch without causing clinical signs, intermittently shedding into the environment, and encountering naïve animals. Insight into theS. equigenome and lifestyle has led to advances in diagnostic assays and the development of a safe and efficacious recombinant‐fusion vaccine, giving clinicians and caregivers the tools to better combat this infection. Alongside rigorous biosecurity protocols and pragmatic control measures such as screening new arrivals for exposure and carrier status, these new technologies demonstrate that strangles can be an increasingly preventable infection.
Carbon dioxide‐induced decrease in extracellular pH enhances the production of extracellular matrix components by upregulating TGF‐β1 expression via CREB activation in human dermal fibroblasts
Authors: Takano Kei , Kasamatsu Shinya , Aoki Mika , Takahashi Yoshito 
Published: June 2023

AbstractMild acidification caused by transcutaneous administration of carbon dioxide (CO2) has been reported to improve some epidermal skin impairments, such as desquamation and inflammation; however, its effects on dermal tissue remain unclear. Here, we examined the effect and mechanism of mild acidity on extracellular matrix (ECM) protein production in normal human dermal fibroblasts (NHDFs). To achieve this, the skin permeability of CO2 and its effect on intradermal pH were evaluated by treating reconstructed human skin equivalents (HSEs) with a CO2‐containing formulation. Additionally, NHDFs were cultured in a pH‐adjusted medium (pH 6.5). CO2 successfully permeated HSEs and reduced the intradermal pH. Decreased extracellular pH activated CREB, upregulated TGF‐β1 expression, promoted the production of elastic and collagen fibres, and increased hyaluronan concentration in NHDFs. Additionally, the low pH‐induced increase in TGF‐β1 expression was attenuated via the RNAi‐mediated suppression of the expression of CREB1 and proton‐sensing G protein‐coupled receptors (GPCRs), including GPR4 and GPR65. Moreover, low pH‐induced CREB activation was suppressed by the inhibition of the cAMP/PKA and PLC/PKC signalling pathways. Taken together, a CO2‐induced decrease in intradermal pH may promote ECM production in NHDFs via the upregulation of TGF‐β1 expression, which was mediated by the activation of the GPCR signalling pathway and CREB, indicating that CO2 could be used to treat ultraviolet radiation‐induced photoaging, intrinsic ageing and ECM deterioration.
Rapamycin improves social and stereotypic behavior abnormalities induced by pre‐mitotic neuronal subset specific Pten deletion
Authors: Narvaiz David A. , Nolan Suzanne O. , Smith Gregory D. , Holley Andrew J. , Reynolds Conner D. , Blandin Katherine J. , Nguyen Phuoc H. , Tran Doan L. K. , Lugo Joaquin N. 
Published: June 2023

AbstractThe mechanistic target of rapamycin (mTOR) pathway is a signaling system integral to neural growth and migration. In both patients and rodent models, mutations to the phosphatase and tensin homolog gene (PTEN) on chromosome 10 results in hyperactivation of the mTOR pathway, as well as seizures, intellectual disabilities and autistic behaviors. Rapamycin, an inhibitor of mTOR, can reverse the epileptic phenotype of neural subset specific Pten knockout (NS‐Pten KO) mice, but its impact on behavior is not known. To determine the behavioral effects of rapamycin, male and female NS‐Pten KO and wildtype (WT) mice were assigned as controls or administered 10 mg/kg of rapamycin for 2 weeks followed by behavioral testing. Rapamycin improved social behavior in both genotypes and stereotypic behaviors in NS‐Pten KO mice. Rapamycin treatment resulted in a reduction of several measures of activity in the open field test in both genotypes. Rapamycin did not reverse the reduced anxiety behavior in KO mice. These data show the potential clinical use of mTOR inhibitors by showing its administration can reduce the production of autistic‐like behaviors in NS‐Pten KO mice.
A guide to relocating your laboratory
Authors: Liston Adrian , Dooley James 
Published: June 2023

AbstractResearch positions have become increasingly less stable, thus increasing the frequency at which research laboratories need to be relocated. A laboratory relocation can be a positive transition for you and your team; however, it requires careful planning in order to minimize the disruption and mitigate potential harms. Here we discuss key planning steps involved in successfully relocating your laboratory.
Do brushings taken during bronchoscopy for suspected primary lung cancer increase diagnostic yield? An audit of real‐world clinical practice
Authors: Davidson Dorothy , Page Matthew , Budge David , Goodwin Rebekah , Kim Sewoon , Trembath Aaron , Wood Jonathan , Dummer Jack , Parkin Lianne 
Published: June 2023

AbstractWe reviewed clinical records to determine whether the use of bronchial brushings improved diagnostic yield in a setting where bronchoscopy for suspected primary lung cancer is routinely guided by prior chest computed tomography but endobronchial ultrasound‐guided sampling is unavailable. For 29% of cases who had brushings and at least one other test taken (bronchial biopsies or washings), the histological diagnosis was made solely on the basis of samples obtained by brushings.
Evaluation of the electrocardiogram RV5/V6 criteria in the diagnosis of left ventricular hypertrophy in marathon runners
Authors: Yang Pan , Ge Zhixiang , Gao Jinmei , Liu Xia , Xu Min , Ke Haiyan 
Published: June 2023

AbstractTo assess the value of electrocardiogram (ECG) RV5/V6 criteria for diagnosing left ventricular hypertrophy (LVH) in marathons. A total of 112 marathon runners who met the requirements for “Class A1” events certified by the Chinese Athletics Association in Changzhou City were selected, and their general clinical information was collected. ECG examinations were performed using a Fukuda FX7402 Cardimax Comprehensive Electrocardiograph Automatic Analyser, whereas routine cardiac ultrasound examinations were performed using a Philips EPIQ 7C echocardiography system. Real‐time 3‐dimensional echocardiography (RT‐3DE) was performed to acquire 3‐dimensional images of the left ventricle and to calculate the left ventricular mass index (LVMI). According to the LVMI criteria of the American Society of Echocardiography for the diagnosis of LVH, the participants were divided into an LVMI normal group (n = 96) and an LVH group (n = 16). The correlation between the ECG RV5/V6 criteria and LVH in marathon runners was analysed using multiple linear regression stratified by sex and compared with the Cornell (SV3 + RaVL), modified Cornell (SD + RaVL), Sokolow–Lyon (SV1 + RV5/V6), Peguero–Lo Presti (SD + SV4), SV1, SV3, SV4, and SD criteria. In marathon runners, the ECG parameters SV3 + RaVL, SD + RaVL, SV1 + RV5/V6, SD + SV4, SV3, SD, and RV5/V6 were able to identify LVH (all p < .05). When stratified by sex, linear regression analysis revealed that a significantly higher number of ECG RV5/V6 criteria were evident in the LVH group than in the LVMI normal group (p < .05), both with no adjustment and after initial adjustment (including age and body mass index), as well as after full adjustment (including age, body mass index, interventricular septal thickness, left ventricular end‐diastolic diameter, left ventricular posterior wall thickness, and history of hypertension). Additionally, curve fitting showed that the ECG RV5/V6 values increased with increasing LVMI in marathon runners, exhibiting a nearly linear positive correlation. In conclusions, the ECG RV5/V6 criteria were correlated with LVH in marathon runners.
Advances in processing, encapsulation, and analysis of food flavor compounds
Authors: Gan Sunlong , Zhang Min , Mujumdar Arun S. , Zhang Lihui , Liu Yaping 
Published: June 2023

AbstractIn recent years, the market for edible flavor has become larger and the demand for edible flavor has become more diverse. Customers are paying more attention to natural, healthy, and functional flavors. This article reviews some new technologies about flavors in recent years, including processing technology, encapsulation, and detection of flavors. The synthetic technologies of flavor include thermal reaction technology, enzymatic hydrolysis technology, and microbial fermentation technology. The encapsulation technology includes nano‐emulsion and filled soluble hydrogel, as well as the new carrier materials used in packaging, such as β‐cyclodextrin, 2‐acetyl‐1‐pyrroline (2AP), yeast cell, and jackfruit seed starch (JM) are also hot spots in recent years. Finally, the detection of flavor components and the monitoring of characteristic flavor substances and harmful flavor substances are very important for flavor quality control. There are many detection techniques, such as chromatographic analysis techniques, solid‐phase microextraction, electronic nose and electronic tongue, sensor arrays, and fluorescence detection with DNA barcoding techniques and (quantitative) conformational relationships.
Disentangling the role of light and nutrient limitation on bacterivory by mixotrophic nanoflagellates
Authors: Princiotta Sarah DeVaul , VanKuren Andrew , Williamson Craig E. , Sanders Robert W. , Valiñas Macarena S. 
Published: June 2023

AbstractMany phytoplankton taxa function on multiple trophic levels by combining photosynthesis and ingestion of bacteria, termed mixotrophy. Despite the recognition of mixotrophy as a universal functional trait, we have yet to fully resolve how environmental conditions influence community grazing rates in situ. A microcosm study was used to assess bacterivory by mixotrophic nanoflagellates following nutrient enrichment and light attenuation in a temperate lake. We found contrasting results based on assessment of mixotroph abundance or bacterivory. Despite an interactive effect of nutrient enrichment and light attenuation on mixotroph abundance, significant differences within light treatments were observed only after enrichment with P or N + P. The greatest abundance of mixotrophs across treatments occurred under co‐nutrient enrichment with full exposure to irradiance. However, bacterivory by mixotrophic nanoflagellates was greatest under shaded conditions after either N or P enrichment. We suggest that PAR availability dampened the stimulatory effect of nutrient limitation, and bacterivory supplemented a suboptimal photosynthetic environment. In a saturating light regime, the mixotrophic community was less driven to ingest bacteria because photosynthesis was able to satisfy energetic demands. These findings quantify community bacterivory in response to environmental drivers that may characterize future ecosystem conditions and highlight the importance of considering grazing rates in conjunction with abundance of mixotrophic protists.