bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural inhibitors of DYRK1A as drug candidates against Alzheimer Disease: QSAR, molecular docking, molecular dynamics simulation and drug evaluation assessment
Authors: Abduljelil Ajala , Uzairu Adamu , Shallangwa Gideon A. , Abechi Stephen E. , Ramu Ramith , Kumar Naveen 
Published: January 2023

AbstractAlzheimer’s disease (AD) is a dementia neurodegenerative disorder with complex mechanisms and no cure that gradually leads to loss of learning, remembering, imagining, and recalling past events. It is most commonly found in adults aged 65 and up. The research scientists are interested in producing new drugs and new drug targets that can cure or inhibit this incurable disease. TheIn-silicotechnique was used to investigate the inhibitory activities of Natural inhibitors of DYRK1A against AD. All the ligands, including the reference drug, were docked using molecular docking. The docked complex was validated experimentally with the aid of molecular dynamics simulation. Trajectory plots of compound 19 were evaluated using RMSD, RMSF, Rg, SASA, and Ligand hydrogen bonds. This stability of compound 19 was further confirmed by the RMSF, Rg, SASA, and ligand hydrogen bond. Evidently, compound 19 may have undergone alteration and formed more H-bonds with macromolecules during the 100 ns simulation than harmine (the reference drug), therefore, compound 19 has been more stable. The three ligands emerged with better docking values than the reference drug, which shows that the compounds have therapeutic ability to hinder or cure the damage caused by this disease. Also, the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) proved that the ligands have good pharmacokinetic abilities. It is obvious from the aforementioned results that the generated model is good and are highly potent, non-toxic, and penetrate the BBB (blood-brain barrier) so as to circumvent the effect of the AD.
The Brenham impact event, 693-552 years ago (1329-1470 CE)
Authors: Tankersley Kenneth Barnett , Meyers Stephanie A. , Stimpson Don I. , Knepper Sheila M. 
Published: January 2023

Abstract
More than 10,000 kg of pallasites, micrometeorites (< 4 mm), positive Ir and Pt anomalies, and ~ 80 ha of impact craters have been found across an ~ 800 ha strewn field on the late Holocene surface of Kiowa County, Kansas. A suite of six AMS radiocarbon ages demonstrate that a cosmic impact event occurred sometime between 693 and 552 years ago, 1329–1470 CE. This event is recorded in Native American oral histories and petroglyphs located near the strewn field. Hopewell artifacts in the Ohio River valley postdate the impact event by more than 1,000 years. The Brenham impact event increases our understanding of the occurrence and effect of cosmic events on humans.
An approximate solution of differential inclusion with prox-regular set
Authors: Beddani A. , Sahraoui R. 
Published: January 2023

Abstract
The aim of this paper is to calculate the approximate solution of differential inclusion with prox-regular set, the question is how to calculate this solution? We use the discrete approximation property of a new variant of nonconvex sweeping processes involving normal cone and a finite element method. Knowing that the majority of mathematicians have proved only the existence and uniqueness of the solution for this type of inclusions, like: Mordukhovich, Thibault, Aubin, Messaoud,...etc.
MSC Classification: 34A60 , 49J52 , 37B25.
Inclusive landscape governance: Forest welfare services and forest value orientation in the National Luxury Forest, South Korea
Authors: Kim Lankyung , Li Ching 
Published: January 2023

Abstract

This study explores a case of inclusive landscape governance by employing forest welfare services and forest value orientation in the National Luxury Forest, South Korea. Among the multifaceted attributes of landscape approaches, forest recreation as a cultural ecosystem service focuses on opening a discourse about forest welfare approaches. Forest value orientation from end-user perspectives in inclusive governance is measured semi-quantitatively using web-content-based text data. Three level dimensions of forest recreation services – basic, expanded, and special – are confirmed through official documentaries; bifurcated value orientation – ecology and sentiment – is elicited from text data analysis. Canonical correlation from the text data manipulation indicates that forest recreation services and forest value orientation are related to the association of forest cultural ecosystems promoted by inclusive landscape governance. This study satisfies the future criteria of integrated landscape approaches in which assessing inclusive governance under empiricism is required. Moreover, the study can provide insights into building an ideal link between policy and management in the state forests.
Waning vaccine response to severe COVID-19 outcomes during omicron predominance in Thailand
Authors: Intawong Kannikar , Chariyalertsak Suwat , Chalom Kittipan , Wonghirundecha Thanachol , Kowatcharakul Woravut , Thongprachum Aksara , Chotirosniramit Narain , Noppakun Kajohnsak , Khwanngern Krit , Teacharak Worachet , Piamanant Prapon , Chantaklang Pannawich , khammawan Pimpinan 
Published: January 2023

Abstract

Background: The COVID-19 pandemic has evolved quickly, with different variants of concern resulting in the need to offer continued protection through booster vaccinations. The duration of enhanced protection with booster doses against severe COVID-19 is still unclear and understanding this is critical to recommendations on frequency of future booster doses.
Methods: Utilising a Hospital Information System for COVID-19 established in Chiang Mai, Thailand, we conducted a cohort study by linking patient-level data of laboratory-confirmed COVID-19 cases to the national immunization records, during omicron predominant period (1 February – 31 July 2022).
Results: Out of 261,103 adults with COVID-19 included in the study, there were 333 (0.13%) severe COVID-19 cases and 190 (0.07%) deaths. Protection against severe COVID-19 was highest with boosters received >14-60 days prior to positive test (93%) and persisted at >60-120 days (91%) but started to wane at >120-180 days (77%) and further at >180 days (68%). The rate of waning differed with age. Those ≥70 years showed waning of booster vaccine response as early as >60 days as compared to those aged 18-49 years, who retained good response up to 180 days. Equivalent risk reduction against severe COVID-19 was seen with all the vaccine types used as boosters in Thailand.
Conclusions:Booster doses provided high level of protection against severe COVID-19 with omicron, up to 4 months. Repeat boosters will be required to continue protection beyond 4 months, particularly in elderly. mRNA and viral vector vaccines can be used flexibly to improve booster coverage.
Understanding Glacial Lake Evolution and the Associated GLOF Hazard in Shyok Catchment of Upper Indus Basin
Authors: Rather Abid Farooq , Ahmed Rayees , Bateni Sayed M. , Ahmed Pervez , Mir Riyaz Ahmad 
Published: January 2023

Abstract
As glaciers recede in response to global climate change, a significant growth of glacial lakes is being witnessed in the Himalayan region. Owing to their high elevations, rapid growth and mostly unstable dams constituting of loosely consolidated glacial moraine deposits, these lakes pose a significant threat in the form of Glacial Lake Outburst Floods (GLOFs). This study focused on studying the evolution of glacial lakes in Shyok catchment of Upper Indus basin, over a period of 30 years (1992 to 2022) and assessing their GLOF hazard levels. The Inventorization and Spatio-temporal change detection of the glacial lakes (A≥0.001 km2) was done using multi-temporal medium and high-resolution satellite imagery from the years 1992, 2002, 2012 and 2022. Besides, we have used Google Earth and Planet imagery, to validate the glacier and glacial lakes outlines. The GLOF hazard level assessment was carried out through a multi-criteria approach using Analytical Hierarchy Process AHP to classify the lakes into very-low, low, medium, high and very-high hazard categories. The results reveal a significant increase in the total number of glacial lakes from 143 in 1992 to 240 in 2022 as well as the total glacial lake area that increased from 8.45 km2 (± 0.02 km2) in 1992 to 13.26 km2 (± 0.04 km2) in 2022. Furthermore, out of 63 glacial lakes (A>0.05 km2) selected for the hazard assessment, 7 lakes were identified as very-high hazard lakes with GLOF susceptibility indices greater than 7.0 while 19 more lakes were classified as High-hazard lakes with GLOF susceptibilities in the range of 0.6 to 0.7. Most of these lakes are proglacial lakes and are close to their mother glaciers. The majority of these hazardous lakes have witnessed a high growth rate, which suggests that the GLOF hazard of these lakes is going to increase further in the future owing to the warming climatic trends. This study will act as a precursor to a more detailed and in-depth GLOF risk assessment of highly hazardous glacial lakes in the region and will help in developing mitigation strategies for any potential disasters in future.
Determination of levofloxacin, norfloxacin, and moxifloxacin in pharmaceutical dosage form or individually using derivative Uv spectrophotometry
Authors: Osman Alsayed Fadel 
Published: January 2023

Abstract
The first, second, third, and fourth-order derivative spectrophotometric methods by using the peak—zero (P - O) and peak-peak (P - P) techniques of measurement have been developed for the determination of levofloxacin, norfloxacin, and moxifloxacin in their combined pharmaceutical dosage form or individually for levofloxacin, norfloxacin, and moxifloxacin. Linearity was achieved in 2–20 µg/ml. The procedure is simple, quick, and precise. The developed method has been shown to be sensitive and precise. Simple, accurate, and cost-effective, and exhibited good correlation coefficient (R2 = 0.9998) and excellent mean recovery (99.20–100.08%), indicating a high degree of precision of the methods. This approach was successfully used to determine the levofloxacin, norfloxacin, and moxifloxacin content in marketed pharmaceutical dosage. The method's linearity, accuracy, were confirmed statistically and through recovery tests. The obtained findings demonstrated that the approach may be used for routine analysis in bulk and commercial formulations.
The Mirror Reversal Mechanism on Black Hole Collapse and Singularity Eruption in Cosmic Continuum
Authors: Wang Xijia 
Published: January 2023

Abstract
In the Big Bang Theory and the Black Hole Theory, the existing laws of physics all fail at the singularity, and the singularity has become a blind spot in the existing scientific theories. In the axioms system of Cosmic continuum, the universe was not created by an instantaneous explosion, but by the continuous eruption of singularities. As long as the singularity is still erupting, the total amount of the universe will continue to increase. The so-called dark energy is actually the gravitational field energy erupted by the singularity. The expansion force of dark energy is generated by the outward eruption of singularity. The cosmic system collapse into a Schwarzschild black hole under the action of a strong gravitational field, and the Planck spheres at the center of the black hole continues to collapse into dark mass bodies, forming dark celestial body and singularity. The Schwarzschild radius is the upper limit of a black hole, and the Planck sphere is the lower limit of a black hole. The singularity is the conversion point between the old and new cosmic systems. The singularity erupts the Planck spheres under the action of a strong gravitational field, and the Planck spheres expands outward to form a new cosmic system. The Planck sphere is both the end of the old cosmic system and the starting point of the new cosmic system. The black hole collapse and the singularity eruption are mirror images of each other.
Analysis projectile performance in ballistic tests using compressed air gun
Authors: Purwanto Helmy , Tauviqirrahman Mohammad , Sugiarto Sugiarto , Dzulfikar Muhammad 
Published: January 2023

Ballistic resistance is affected by the projectile and armor material used. The character and behavior of the projectile affects its ability to damage and penetrate armor. The velocity, mass and shape of the projectile are the main factors in determining the ability of the projectile to penetrate armor in this case the target plate. Therefore, this study aims to determine and analyze the effect of projectile mass and shape on the velocity with which it penetrates the armor material using a compressed air gun. Armor material as a ballistic test target using carbon steel plate with a thickness of 0.8 mm; 1.2 mm and 1.8 mm. Projectiles of lead materials with different masses and shapes are fired from the air gun under controlled air pressure, set at 2000 Psi, 3000 Psi, and 4000 Psi to provide thrust in the barrel. The plat target is placed at a distance of 5 m from the air gun. Speed gauges are placed after the air gun and after the target plate to determine the projectile's rate before and after passing through the target plate. The test results concluded that the velocity of the projectile ejected from the compressed air gun was influenced by the magnitude of the pressure and the mass of the projectile. The mass of the projectile has a more dominant effect on the velocity of the projectile compared to the amount of pressure applied. Different projectile shapes with the same mass have no significant effect on the velocity. However, the heavier mass projectile outperforms the lighter mass projectile through the target plate. It is required the right combination of velocity and mass of the projectile to be able to penetrate the target plate
Research of Indonesian license plates recognition on moving vehicles
Authors: Wijaya Marvin Chandra 
Published: January 2023

The recognition of the characters in the license plate has been widely studied, but research to recognize the character of the license plate on a moving car is still rarely studied. License plate recognition on a moving car has several difficulties, for example capturing still images on moving images with non-blurred results. In addition, there are also several problems such as environmental disturbances (low lighting levels and heavy rain). In this study, a novel framework for recognizing license plate numbers is proposed that can overcome these problems. The proposed method in this study: detects moving vehicles, judges the existence of moving vehicles, captures moving vehicle images, deblurring images, locates license plates, extracts vertical edges, removes unnecessary edge lines, segments license plate locations, Indonesian license plate cutting character segmenting, character recognition. Experiments were carried out under several conditions: suitable conditions, poor lighting conditions (dawn, evening, and night), and unfavourable weather conditions (heavy rain, moderate rain, and light rain). In the experiment to test the success of the license plate number recognition, it was seen that the proposed method succeeded in recognizing 98.1 % of the total images tested. In unfavorable conditions such as poor lighting or when there are many disturbances such as rain, there is a decrease in the success rate of license plate recognition. Still, the proposed method's experimental results were higher than the method without deblurring by 1.7 %. There is still unsuccessful in recognizing license plates from the whole experiment due to a lot of noise. The noise can occur due to unfavourable environmental conditions such as heavy rain.
Decısıon makıng for car selectıon ın Vıetnam
Authors: Trung Do Duc , Tien Dung Hoang , Son Nguyen Hoai 
Published: January 2023

Mid-priced cars (segment B) are attracting the attention of middle-income families in Vietnam. They often consider choosing one of three vehicles from three different manufacturers, consisting of Hyundai Accent 1.4AT, Toyota Vios 1.5G, and Honda City 1.5L. This study was carried out to rank those three cars. Twelve criteria for rating each car provided by the dealer were used. These criteria are both qualitative and quantitative, and also fall into all three types, including max, min and another (“Yes”, “No”). The importance of each criterion was determined by experts in a survey. They are all knowledgeable about cars. Two multi-criteria decision making (MCDM) methods including R (A simple ranking method for multi-attribute decision making in the industrial environment) and CURLI (Collaborative Unbiased Rank List Integration) method were applied for ranking. This is the first work that has used both methods mentioned above. The result revealed that the rank of the alternatives is the same when both the methods were used. This result gives us a certain confidence when choosing a car. Accordingly, Honda City 1.5L is ranked first. R and CURLI not only succeeded in ranking cars in this study, but also promise to be successful when used in other situations. Moreover, other criteria for evaluating the vehicle options that have not been surveyed in this study are mentioned in the last section of this paper. They need to be further considered to include in other next studies for car selection
Electrical characterisation and analysis of dominant contributions in disordered semiconducting systems with an application to the pure bentonite material for civil engineering applications
Authors: Essaleh Mohamed , Bouferra Rachid , Belhouideg Soufiane , Oubani Mohamed , Bouchehma Abdeltif , Benjelloun Mohamed 
Published: January 2023

Semiconductors and clay materials have significant applications in environmental, civil engineering and optoelectronic sectors. The application of an electric field to such systems is subject of many works. However, to understand the behaviour of such materials under the influence of an electric field, the perception of its electrical properties is essential. In the present study, the powerful technique of complex impedance spectroscopy (CIS) is introduced to illustrate the electrical characteristics of two types of disordered semiconducting materials. These are Cu5In9Se16, an ordered defect compound of the I-III-VI2 family and a novel bentonite clay system which is an insulator at room temperature and semiconductor above 400 °C. Na-bentonite has been studied extensively because of its strong adsorption capacity and complexation ability while Cu5In9Se16 is considered for its use in solar and phtovoltaique domain. Some of selenides have turned out to be leading materials for electro-optical devices and the tellurides for thermoelectric power generation. It is very likely that study of bentonite clay and other similar materials may lead to the technology of heterojunction and clay composite. The frequency dependence of conductivity of bentonite was investigated using an impedance analyzer in the frequency range (20 Hz–1 MHz). The experimental data of CIS are analyzed using some analytical methods that take into account the effect of the grains and grain boundaries. The impedance data confirm the non-Debye behavior in these systems. Some important parameters related to the identified dominant contribution such as relaxation time and activation energies are estimated for the studied materials in the considered temperature and frequency ranges
Numerical simulation of the inlet channel geometry influence in the torque generated at the gravitation water vortex turbine
Authors: Burbano Andres , Sierra Jorge , Correa Edwin , Ruiz Alejandro , Sanin Daniel 
Published: January 2023

The gravitational water vortex turbine is presented as an alternative for electric power generation for both low head and water flow conditions, additionally it is easy and low cost to implement and maintenance. However, the experimentally reported efficiencies motivate the scientific community to develop new geometries in order to improve its performance. First, it is not clear how the efficiency of the turbine is obtained and second, not all studies report it. The turbine is mainly made up of a tank, the rotor and the electric generator. The geometry of the tank is important because it stabilizes the fluid and in this component that the generation of the vortex is induced, which determines, added to other factors like tank geometry and runner, the global efficiency of the turbine. The primary purpose of this study is to compare numerically the torque generated at six (6) geometrical configurations of the basin inlet channel for Gravitational Vortex Turbine (GVT) with a Savonius rotor. The study was developed in ANSYS® CFX, where a transient state VOF model was configured with a BSL K − ω turbulence model and a discretization a discretization of the control volume made in the ICEM module. The highest torque was 0.553 Nm at 25 rpm for the trapezoidal curved inlet channel geometry, increasing the efficiency respect to the conventional Square inlet channel of the 2.73 %. The increase of tangential velocity contributes positively to the vortex generation, and consequently, an increase in torque is obtained. On the other hand, the design of the rotor considerably affects the performance of the GVT, where it may or may not take advantage of the kinetic energy of the vortex
Effect of the Ultraviolet Radiation on the Lens
Authors: Borges-Rodríguez Yissell , Morales-Cueto Rodrigo , Rivillas-Acevedo Lina 
Published: January 2023

Abstract:
The lens is a transparent, biconvex anatomical structure of the eyes responsible for light
transmission and fine focusing on the retina. It is fundamentally constituted by water-soluble proteins
called crystallins which are responsible for lens transparency due to their stable and highly organized
disposition in the lens fiber cells. Some conformational changes and the subsequent aggregation of
crystallins lead to loss of transparency in the lens and are the beginning of cataracts, which is the most
frequent cause of reversible blindness in the world. Ultraviolet radiation is considered one of the risk
factors for cataract development. The lens is exposed to radiation between 295 and 400 nm. This UV
radiation may induce several processes that destroy the crystallins; the most significant is the oxidative
stress due to increased free radicals formation. The oxidative stress is directly involved in modifications
of the crystallin proteins leading to the formation of high molecular weight aggregates and then
the subsequent opacification of the lens, known as cataracts. This review aims to summarize current
knowledge about the damage of the lens proteins caused by ultraviolet radiation and its role in developing
cataracts.