bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial Treatment Response and Short-term Mortality of Spontaneous Bacterial Peritonitis in Cirrhotic Patients with Hepatocellular Carcinoma
Authors: Lee Chang Hun , Kang Hye Jin , Yu Song Yi , Seo Seung Young , Kim Seong Hun , Kim Sang Wook , Lee Seung Ok , Lee Soo Teik , Kim In Hee 
Published: January 2023

Abstract
This study aimed to investigate the initial treatment response and short-term mortality of spontaneous bacterial peritonitis (SBP) in cirrhotic patients with hepatocellular carcinoma (HCC) compared with those without HCC. A total of 245 patients with liver cirrhosis diagnosed with SBP between January 2004 and December 2020 were included. Of these, 107 (43.7%) were diagnosed with HCC. Overall, the rates of initial treatment failure, 7-day and 30-day mortality were 91 (37.1%), 42 (17.1%), and 89 (36.3%), respectively. While the baseline CTP score, MELD score, culture-positive rate, and rates of antibiotic resistance did not differ between both groups, patients with HCC had a higher rate of initial treatment failure than those without HCC patients (52.3% vs. 25.4%, P<0.001). Similarly, 30-day mortality was also significantly higher in patients with HCC (53.3% vs. 23.2%, P<0.001). In the multivariate analysis, HCC, renal impairment, CTP grade C, and antibiotic resistance were independent factors for initial treatment failure. Furthermore, HCC, hepatic encephalopathy, MELD score, and initial treatment failure were independent risk factors for 30-day mortality, with statistically significant poor survival outcomes in patients with HCC and initial treatment failure (P<0.001 and P<0.001, respectively). In conclusion, HCC is an independent risk factor for initial treatment failure and high short-term mortality in patients with cirrhosis with SBP. It has been suggested that more attentive therapeutic strategies are required to improve the prognosis of patients with HCC and SBP.
Grow Newtonian rigid inertia into parameter repetitiveness memory equivalent bio-inertia by degenerating eigenstates on a surface tension region to define quantum growth gravity for turnover selection
Authors: Lai Yi Yu 
Published: January 2023

Abstract
Note: Please see pdf for full abstract with equations.
Inversion energy is parameter-against-gravity-internal-fluctuation, the non-simultaneousness in gravitationally correlated internal fluctuations is quantizing time. Modified Newtonian Laws are, first: 𝑑/𝑑𝑥 cosx =−𝑠𝑖𝑛𝑥, 𝑑/𝑑𝑥 sinx = 𝑐𝑜𝑠𝑥; second: 𝐹⃗=𝑚∙𝑎⃗+|𝑚𝑔⃗∫𝑡𝑔𝜃⋅𝑑𝜃 ⟩↿⇂ third: Wavelength =2/𝑛 L, frequency = n𝑓0. Bio-systems are topological spaces that can process input objects into inversion energy for entropy-control by repetitiveness memory, the capability of equivalent procured inversion energy with memorized trigonometric repetitiveness by quantizing time is bio-inertia. Schrödinger equation has only quantized energy but hasn’t quantized time thus inducing quantum collapse, we then write down equation 𝑯̂𝜓=𝑬𝜓 + Σn|cos(1/𝑛 𝑥)⟩ to grow eigenstates on certain surface tension regions to define quantum growth gravity for lifespan. Originating from elastic quantum scale differences between Planck regions and surface tension regions, bio quantum duality grows in vivo cross folded-surface tension region flow. Life relies on trigonometric negentropy procured from elastic entropy generation ground condensates and physically inherit by bio quantum growth turnover selection. Long COVID niche grows from the turnover tension is also unveiled.
Biocontrol performance and mass production potential of the larval endoparasitoid Campoletis chlorideae against Spodoptera frugiperda
Authors: Zhang Rui , Zhao Qi , Mohamed Amr , Lei Xianfu , Leppla Norman , Liu Canghua , Zhang Wei , Zang Lian-sheng 
Published: January 2023

Abstract
Spodoptera frugiperda is an invasive pest that causes severe economic losses in outbreak regions. The use of natural enemies of S. frugiperda, particularly native parasitoids, has been suggested as a promising control strategy due to high rates of pesticide resistance. Campoletis chlorideae is a solitary larval endoparasitoid with a broad host range that includes S. frugiperda; however, its parasitism rate, developmental stages, and population dynamics during S. frugiperda infection remain unclear. Here, we performed a systematical analysis to evaluate the biological control performance of C. chlorideae on the fall armyworm through age-stage, two-sex life tables. Due to their reproductive ability and short-life cycle, fall armyworms have the potential to be developed as a mass production host of C. chlorideae, we investigated the mass production potential by group-rearing fall armyworms using a low cannibalism rate artificial diet. Our results revealed an adequate biological control performance of C. chlorideae on S. frugiperda with a lifetime fecundity of 301.5 eggs/female, net reproduction rate (R0, adult females reproduced by a female) of 62.5, longevity of 28 days, and intrinsic rate of increase (r) of 1.2148. However, mass production factors require further optimization to improve efficiency and reduce the cost, as there was a lower net reproduction rate (6.02) due to the parasitization-induced cannibalism. This study provides instruction and guidance for the application and release of C. chlorideae for control of the fall armyworm.
DDX58 and CXCL10 have potential as key biomarkers for lymph node tuberculosis
Authors: Wang Liang , Maimaiti Naifeisha · , Zhang Li , Sun Hu , Fan Jiahui , shi Ning , Shang Xiaoqian , Zhang Xiufeng , Wang Jing , Ma Xiumin 
Published: January 2023

Abstract

Aim
To explore the pathogenic mechanism of lymph node tuberculosis and to mine potential key genes.
Methods
Gene expression profiles of pulmonary tuberculosis (GSE83456), lymph node tuberculosis (GSE63548) and healthy controls were downloaded from the Gene Expression Omnibus (GEO) database. Screening common differentially expressed genes (DEGs) in pulmonary tuberculosis and lymph node tuberculosis, enrichment analysis of DEGs and their functionally related modules were performed. Cytoscape was used to screen hub genes, and verify their expression levels, further predict transcription factors to mine the final key genes, and then verify the diagnostic efficacy of key genes for lymph node tuberculosis by ROC curves.
Results
60 differential genes involved in pulmonary tuberculosis and lymph node tuberculosis were screened for subsequent analysis. Functional enrichment analysis highlights that type I interferon-mediated signaling and viral infection play important roles in pathogenicity. Subsequently, 14 hub genes were screened and their expression was significantly upregulated in tuberculosis patient. 4 transcription factors involved in regulating hub genes were further mined. DDX58 and CXCL10, which are regulated by transcription factors IRF1, are considered key genes, and the ROC results suggested good diagnostic efficacy, AUC are 0.992 and 0.974 respectively.
Conclusions
Our study revealed a common pathogenesis of pulmonary tuberculosis and lymph node tuberculosis. DDX58 and CXCL10 play an important role that cannot be ignored, and provide new ideas for further investigation of biomarkers in lymph node tuberculosis disease.
Effectiveness Analysis of Abrasive Flow Machining on Elbow Inner-surface Finish
Authors: Li Junye , Tian Gongqiang , Yin Yanlu , Shi Guangfeng , Zhang Jingran , Zhang Xin-Ming 
Published: January 2023

Abstract
Higher standards have been set for elbow-type parts' inner-surface finish in industrial production. The influence mechanism of inlet velocity, bend ratio, and bending angle on the surface quality of elbows is analyzed to study the surface quality control technology of abrasive flow machining (AFM) elbows, and the surface quality control method of elbows in AFM is established. The results of the numerical simulation demonstrate that a suitable increase in inlet velocity can enhance the machining effect of the abrasive flow; a smaller curvature radius has a higher machining intensity and a larger curvature radius has a better overall machining uniformity; the numerical simulation also confirms that the analysis of the flow state in the 90° elbow applies to elbows with different bending angles, demonstrating the analysis's applicability. The test results of the curvature radius are consistent with the results of the numerical simulation, and for a larger curvature radius, the inlet velocity or inlet pressure can be increased appropriately to achieve better surface quality control. The test results of the inlet pressure show that increasing the inlet pressure can improve the machining effect of the abrasive flow, indicating that the inlet pressure and inlet velocity are proportional to each other. Therefore, the experimental findings confirm the accuracy of the numerical calculations and offer technical support for the elbow AFM quality control system that has been developed.
SpaTiaL: Monitoring and Planning of Robotic Tasks Using Spatio-Temporal Logic Specifications
Authors: Pek Christian , Schuppe Georg Friedrich , Esposito Francesco , Tumova Jana , Kragic Danica 
Published: January 2023

Abstract
Many tasks require robots to manipulate objects while satisfying a complex interplay of spatial and temporal constraints. For instance, a table setting robot first needs to place a mug and then fill it with coffee, while satisfying spatial relations such as forks need to placed left of plates. Existing solutions are often not robot-agnostic, not expressive enough to monitor and plan complex tasks, and require users to manually define object relations. We propose the spatio-temporal framework SpaTiaL that unifies the specification, monitoring, and planning of object-centric robotic tasks. SpaTiaL captures diverse spatial relations between objects and temporal task patterns. Our experiments with recorded data, simulations, and robots demonstrate how SpaTiaL provides real-time monitoring and facilitates online planning. SpaTiaL is open source and easily expandable to new object relations and robotic applications.
Cultural Competence of Nursing Educators at Medical Universities of 2 nd Regional Planning in Iran
Authors: Majnoon Sahand , Yates Vivian M. , Asgarpour Hossein , Aghazadeh Ahmad , Lotfi Mozhgan 
Published: January 2023

Abstract
Background: One of the facets of nursing care, as a holistic profession, is cultural care. Considering the role of culture in individuals’ health behaviors, nurses are recommended to be mindful of cultural care. Since nursing educators should be culturally competent to teach cultural care to students, this study aimed to determine the cultural competence of nursing educators of medical sciences universities in the 2nd regional planning in Iran.
Methods: The current research was a descriptive and survey study framed within Campinha-Bacote’s cultural competency model. All nursing educators of universities of medical sciences in the 2nd regional planning of Iran (Tabriz, Urmia, Ardabil, Khoy, Maragheh, Sarab, and Khalkhal) were considered as research units, and the cultural diversity questionnaire for nursing faculties (CDQNE-R) was sent to them. Out of 129 questionnaires sent, 84 were turned back. The data were analyzed by the SPSS 26 software.
Results: The results of this study showed that the research participants agreed with the subscales of cultural awareness, cultural knowledge, cultural skill, and cultural desire according to Sealey and Yates’ interpretation scale. Also, the research units cast doubts on the cultural encounter subscale. The mean scores of the participants' responses to the questions of every subscale equaled 4.11, 3.52, 3.71, 3.38, and 3.93 for the subscales of cultural awareness, cultural knowledge, cultural skill, cultural encounter, and cultural desire, respectively. Likewise, the mean scores of participants' responses to the subscales of transcultural educational behaviors and general cultural competence equaled 3.90 and 3.73.
Conclusions: The nursing faculties participating in the present study agreed with the 4 sub-models of Campinha-Bacote cultural care and the presence of cultural competence criteria. Also, the research units had doubts about the cultural encounter subscale. This result means that the research participants were undecided about their level of participation in face-to-face interactions with people from different cultural, racial, and ethnic groups. According to the results of the study, it is important to hold transcultural nursing training workshops and courses to maintain and improve the level of cultural competence of nursing faculties at universities of medical sciences in the 2nd regional planning in Iran.
Modulation instability, rogue waves of the seventh-order nonlinear Schrödinger equation on a periodic background
Authors: Jiang Dongzhu , Zha Qi-Lao 
Published: January 2023

Abstract
In this paper, after investigating the modulation instability (MI) of the seventh-order nonlinear Schrödinger (NLS) equation, the rogue wave solutions on the background of the Jacobi elliptic functions dn and cn for a seventh-order NLS equation is constructed. On the background of the Jacobi elliptic function, through the approaches of the nonlinearization of spectral problem and Darboux transformation, two kinds of rogue periodic waves are obtained. Finally, the nonlinear dynamics of two kinds of rogue periodic waves are analysed.
Sea floor characterization by multiples’ amplitude in monochannel surveys
Authors: Vesnaver Aldo , Baradello Luca 
Published: January 2023

Abstract
Lithological characterization of the seafloor is key information for offshore engineering, especially when it comes to pier and platform design. Drilling and coring can be used for local sampling, but continuous profiles or even areal coverage are far preferable. High-resolution seismic profiles are successfully used when ports are not too busy, but otherwise single-channel systems must be used. We show in this paper that even these simpler systems can be used to estimate parameters such as the acoustic impedance of shallow sediments directly beneath the seafloor. We exploit the amplitude decay of the multiple reflections between the seafloor and the surface, which does not depend on the source energy. If the offset between source and receiver is not too small, we can estimate the shallow P velocity and, via the acoustic impedance, also the rock density.
ANN Based Estimation of Pore Pressure of Hydrocarbon Reservoirs - A case study
Authors: Kianoush Pooria , Mohammadi Ghodratollah , Hosseini Seyed Aliakbar , Khah Nasser Keshavarz Faraj , Afzal Peyman 
Published: January 2023

Abstract
In seismic methods, pore pressure is estimated by converting seismic velocity into pore pressure and calibrating it with pressure results during the well-testing program. This study has been carried out using post-stack seismic data and sonic and density log data of 6 wells in one of the fields in SW Iran. While an optimum number of attributes is selected, the General regression (GRNN) provides higher accuracy than Back Propagation (BPNN) at the initial prediction stages. Suitable attributes for estimating compressional velocity (Vp) and density from seismic data are extracted by the Emerge module of HRS.8 software. Acoustic impedance (AI) is the most applicable seismic attribute used as root and reverses AI for estimating P-wave and density. Using a set of attributes can train the system to estimate the property. The correlation coefficient of actual and predicted P-wave using an AI seismic attribute has been calculated as 0.74 and the multi-attribute technique as 0.79. Also, density and three attributes reach from 0.57 to 0.60, which shows a better relationship between seismic attributes and density. After determining optimum layers with the principal components analysis (PCA), formation pressure was modeled with the feed forward-backpropagation (FFBP-ANN) method. Correlation between 0.2 and 0.3 is suitable for generating a neural network layer, and values below 0.2 have a low correlation. Five information layers, including gamma, Vp, AI, density, and overburden pressure, have the most linear convergence with the initial pressure model and are used to modify the ANN model of effective pressure with Petrel 2016 software.
Association of high proprotein convertase subtilisin/kexin type 9 antibody level with poor prognosis in patients with diabetes: A prospective cross-sectional study
Authors: Yamagata Hiroki , Hayashi Aiko , Yoshida Yoich , Koshizaka Masaya , Onishi Shunichiro , Yohida Tomohiko , Hiwasa Takaki , Takemoto Minoru 
Published: January 2023

Abstract
Background
In addition to pathogenic autoantibodies, polyclonal autoantibodies with unknown physiological roles and pathogenicity are produced in the body. Moreover, serum antibodies against the proprotein convertase subtilisin/kexin type 9 (PCSK9) protein, which is integral to cholesterol metabolism, have also been observed. Therefore, we aimed to examine the clinical significance of PCSK9 antibody (PCSK9-Ab) levels.
Methods
We measured blood PCSK9-Ab and PCSK9 protein levels in 109 healthy donors (HDs) and 274 patients with diabetes mellitus (DM) (type 2 DM: 89.8%) using an amplified luminescence proximity homogeneous assay-linked immunosorbent assay. Subsequently, patients with DM were followed up (mean: 4.93 years, standard deviation: 2.77 years, maximum: 9.58 years, minimum: 0.07 years) to examine associations between antibody titers and mortality, myocardial infarction, stroke onset, and cancer.
Results
Although PCSK 9-Ab levels were significantly higher in the DM group than in the HDs group, PCSK9 protein levels were not significantly different. PCSK9-Ab and PCSK9 protein levels showed no correlation in either group. Mortality was significantly associated with higher PCSK9-Ab levels, but unrelated to PCSK9 protein levels. After investigating for potential confounding factors, PCSK9-Ab levels were significantly associated with prognosis in patients with DM.
Conclusions
PCSK9-Ab may be a novel prognostic marker in patients with diabetes, and further studies are warranted to verify its usefulness.
Validation of the Simplified Chinese Palliative Care Nursing Self-competence Scale: Two cross-sectional studies
Authors: Feng Mei , Wang Fang , Liu Qian , Yang Bingxiang , Hao Jie , Yu Sihong , Hu Fen , Luo Dan , Chen Jie 
Published: January 2023

Abstract
BACKGROUND
Due to the increasing burden of life-limiting illnesses, palliative care has been demanded. Nurses’ palliative care competence is a vital factor in improving its accessibility. A reliable instrument is needed. Our aim was to translate and culturally adapt the Palliative Care Nursing Self-Competence scale (PCNSC) into Simplified Chinese (PCNSC-SC).
METHODS
Two cross-sectional studies were conducted after the content validity had been confirmed during the translation and adaption. The convergent validity, construct validity, internal consistency, and homogeneity were evaluated both in the first and second studies. The test-retest reliability was assessed only in the first study. Clinical nurses who had a registered nurse qualification certificate and at least 12 months of work experience from a tertiary hospital in Hubei, China participated in the two studies.
RESULTS
The PCNSC-SC contains eight dimensions and 34 items. Goodness-of-fit indices in confirmatory factor analysis met the criteria. The Cronbach’s alpha of the PCNSC-SC was 0.984 and 0.990 in the two studies, respectively. The test-retest reliability of the PCNSC-SC after two weeks was 0.717.
CONCLUSION
The Simplified Chinese version of the PCNSC (PCNSC-SC) can be used to evaluate perceived self-competence in palliative care of Chinese nurses with good reliability and validity.
The influence of pit and fissure sealing on the oral state and behavior of 12-year-old children.
Authors: Ge Xin , Zhou Huan , Siow Lixuen , Li Xuejing , Xie Yanyi , Hu Yijie , Wan Yao , Fu Danli , Zhu Haihua 
Published: January 2023

Abstract
Background
The World Health Organization (WHO) recommends the age of 12 years as the target age for global caries detection. Insufficient mineralization, pits, and grooves on the tooth surface can lead to accumulation of food residues, increasing the risk of caries in children's newly erupted teeth, within 2–4 years. Therefore, it is important to emphasize the health of teeth in adolescents and to take measures to prevent carie. Approximately 90% of caries in children’s permanent teeth occur in the pits and fissures of posterior teeth. Pit and fissure closure procedures, carried out under the National Oral Disease Intervention Plan for Children, can effectively prevent molar cavity caries. However, Studies conducted in the past 20 years on pit and fissure sealing (PFS) have not evaluated its oral epidemiology. There are few studies on the prevention of caries of the only child, left -behind children and PFS, and the two forms of pit and fissure closure (schools and medical institutions). This study investigated the relationship between pit-and-fissure sealing and oral epidemiological factors in 12-year-old children.
Methods
A total of 1,205 students, aged 12 years, living in Zhejiang Province, China, were randomly selected using stratified sampling. Dental conditions were recorded and basic information about the children, including relevant family information, oral health knowledge, and behavior, was collected through questionnaires.
Results
The results showed that parents' status (e.g., living in urban areas, having mothers with a higher education level), oral health behavior, and knowledge level (floss use, oral health awareness that pit and fissure sealing can protect teeth, and visits to medical institutions to receive dental examinations) are factors promoting the use of pit-and-fissure sealing. The only child and left-behind children have no significant relationship with PFS, and there is no difference between the two forms of pit and fissure closure (schools and medical institutions) in caries prevention.
Conclusions
Our research supports the continued implementation of policies to improve the oral health of children. Financial support for school oral healthcare should be supported and a nationwide school oral health service network should be established.
Therapeutic efficacy of proton pump inhibitor (Omeprazole) on cryptosporidiosis parvum in immunosuppressed experimental mice
Authors: Beshay Engy , Nassef Nashaat E. , Shafey Omaima K. El , Saleh Mona M. , Kora Mona A. , Shalaan Fatma H. 
Published: January 2023

Abstract

Cryptosporidiosis is one of the most frequent food and water-borne diseases. The disease might be life-threatening in immunosuppressed patients. Unfortunately, the only approved drug, nitazoxanide, is with variable efficacies, particularly in malnourished children and immunocompromised patients. Therefore, there is a need to discover an alternative treatment that could be achieved by targeting the metabolic pathways. One of the important enzymes in the glycolysis pathway ofC. parvumis triosephosphate isomerase, which could be hindered by the proton pump inhibitor (PPI) omeprazole. In this study, omeprazole was repurposed againstC. parvuminfection in experimentally immunosuppressed mice. This study was conducted on five mice groups (n = 10). Group I (Normal Control), group II (Infected Control): Mice were infected orally with 1×105C. parvumoocysts on the 15th day of DEX induced immunosuppression. Group III (NTZ-treated): infected and treated by NTZ. Group IV (Omeprazole-treated), and lastly, Group V (NTZ + Omeprazole-treated). The result obtained with omeprazole alone was better than nitazoxanide regarding oocyst shedding reduction percentages (84.9% & 56.1%, respectively). Also, it was better regarding restoration of histopathological and ultrastructural architectures, improvement of liver enzymes (alanine aminotransferase and aspartate aminotransferase) and renal functions (urea and creatinine), and the reduction ofC. parvumtriosephosphate isomerase (TIM) gene expression by RT-PCR. However, the best results were obtained with the combined treatment. Hence, omeprazole could be considered a novel drug option to treat this life-threatening parasitic infection either alone or combined with NTZ, especially in immunosuppressed patients.