bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between adherence to Alternative Healthy Diet Index (AHEI) and severity, disability, duration, and frequency of migraine headache among women: A cross-sectional study
Authors: Khalili Pardis , Mirzababaei Atieh , Abaj Faezeh , Harsini Asma Rajabi , Hajmir Mahya Mehri , Clark Cain C. T. , Mirzaei Khadijeh 
Published: February 2023

Abstract
Background
Migraine is a common brain disorder with pain characteristics that can be defined by moderate to severe unilateral throbbing pain, worsening in physical activity, and can be associated with nausea. Migraine headaches can be caused by numerous factors, including diet. This study aimed to assess the association of adherence to Alternative Healthy Diet Index (AHEI) and severity, disability, duration, and frequency of migraine headache.
Methods
In this cross-sectional study, 266 women (18 to 50 years old) who suffered with migraines, who visited the brain and neurology clinics of Khatam al-Anbia and Sina hospitals and the professional headache clinic in Tehran, were selected. Anthropometric measurements and demographic information were collected. Dietary intake in the past year was assessed using a semi-quantitative, 147-item, food frequency questionnaire (FFQ). AHEI was calculated based on FFQ, and episodic migraine was diagnosed by a neurologist. The Migraine Disability Assessments (MIDAS) questionnaire was used to evaluate migraine disability and migraine severity, visual Analog Scale (VAS) questionnaire was used to measure pain, and duration and frequency were ascertained via questionnaire.
Results
People with high adherence to AHEI, compared with low adherence, had a 43% reduction in headache duration in the crude model (OR = 0.57; 95% CI 0.34, 0.97; P = 0.03), which remained significant after adjusting for potential confounders (OR = 0.56; 95% CI 0.31, 0.99; P = 0.04). However, other variables, VAS, MIDAS and frequency of headache in month, were not significant.
Conclusion
Regarding the association between migraine headache and AHEI, the results of our study showed that people with high adherence of AHEI had a reduction in duration of migraine. Further studies are suggested to better evaluate and understand this association.
Awareness and Perception of Preprints in the Scholarly Community: A Study on India and the SAARC Region
Authors: Das Susmita , Gutam Sridhar 
Published: February 2023

Abstract
A survey of 356 respondents was conducted in April and May 2020 to collect their views and experiences with publications and preprints. Most respondents were from India and were in the field of agricultural science. The survey found that "Journal's Impact Factor" was considered the most important factor when choosing a suitable journal for publication. Most respondents had paid Article Processing Charges (APCs) for their publications, with funding coming from various sources such as project funds, institutional support, and personal funds. Respondents expressed trust in preprints and preferred to use institutional repositories as their preprint platform. The main drivers for sharing preprints were increased indexing, citation and visibility, and the inclusion of preprints in the assessment. Most respondents never cited preprints and reported that their pre-prints had never been cited. Additionally, most respondents reported never editing or withdrawing their pre-prints.
Projections and impact assessment of the local climate change conditions of the Black Volta Basin of Ghana based on the Statistical DownScaling Model
Authors: Siabi Ebenezer K. , Phuong Dang Nguyen Dong , Kabobah Amos T. , Akpoti Komlavi , Anornu Geophery , Incoom Awo Boatemaa Manson , Nyantakyi Emmanuel Kwesi , Yeboah Kofi Antwi , Siabi Sarah Elikplim , Vuu Christopher , Domfeh Martin Kyere , Mortey Eric Mensah , Wemegah Cosmos Senyo , Kudjoe Francis , Opoku Precious Dapaah , Asare Austin , Mensah Samuel Kofi , Donkor Peter , Opoku Emmanuel K. , Ouattara Zié Adama , Obeng-Ahenkora Nana Kwame , Adusu Daniel , Quansah Andrew 
Published: February 2023

Abstract
The uncertainties and biases associated with Global Climate Models (GCMs) ascend from global to regional and local scales which delimits the applicability and suitability of GCMs in site-specific impact assessment research. The study downscaled two GCMs to evaluate effects of climate change (CC) in the Black Volta Basin (BVB) using Statistical DownScaling Model (SDSM) and 40-year ground station data. The study employed Taylor diagrams, dimensionless, dimensioned, and goodness of fit statistics to evaluate model performance. SDSM produced good performance in downscaling daily precipitation, maximum and minimum temperature in the basin. Future projections of precipitation by HadCM3 and CanESM2 indicated decreasing trend as revealed by the delta statistics and ITA plots. Both models projected near- to far-future increases in temperature and decreases in precipitation by 2.05-23.89, 5.41–46.35, and 5.84–35.33% in the near, mid, and far future respectively. Therefore, BVB is expected to become hotter and drier by 2100. As such, climate actions to combat detrimental effects on the BVB must be revamped since the basin hosts one of the largest hydropower dams in Ghana. The study is expected to support the integration of CC mitigation into local, national, and international policies, and support knowledge and capacity building to meet CC challenges.
Synergistic bactericidal activity of ultraviolet radiation, ozone, and liquid-thin-film technology against Escherichia coli in water
Authors: Le Tuan Van , Dang Thanh-Loc Thi , Imai Tsuyoshi 
Published: February 2023

Abstract
Providing effective and sustainable water disinfection methods, without harmful by-products, is essential to protect public health and safety. It is hypothesized that the application of liquid-thin-film (LTF) technology can enhance the bactericidal activity of both ultraviolet (UV) irradiation and ozone (O3) treatments. Therefore, this study aimed to examine the bactericidal activity and synergistic effect of the combined UV + O3 + LTF treatment against Escherichia coli in water processing. The results showed that LTF technology significantly increased the disinfection efficiency of UV and O3 in potable water production. Thus, the combined UV + LTF, O3 + LTF, and UV + O3 + LTF treatments were more effective than the individual treatments under identical conditions. Particularly, the combined double-UV (41.7 mJ cm−2) + O3 (100% O3) + LTF (65 L min−1) treatment exhibited the highest bactericidal activity, resulting in a 5.8-log decrease in the E. coli load within 30 min. Pearson's correlation analysis demonstrated a significant correlation between the synergistic effects of the combined treatments and UV dosage (r = 0.88, p &lt; 0.0001) and aqueous O3 concentrations (r = 0.84, p &lt; 0.0001). These findings suggest that combined UV + O3 + LTF treatment could be a viable alternative method for water disinfection.
Removal performance and mechanism for a three-dimensional electrode system treating biochemical effluent of a wastewater treatment plant
Authors: Tan Mengyu , Zhang Shuchi , Dong Jiayu , Huang Jialu , Wu Xiaolong , Tang Xueni , Wu Donglei 
Published: February 2023

ABSTRACT

With the increasingly strict discharge requirements, it is urgent for wastewater treatment plants (WWTPs) to find an efficient and feasible technology for advanced treatment. A three-dimensional (3D) electrode system was used to treat the real biochemical effluent of a WWTP collecting industrial and domestic wastewater in the present study. The 3D electrode system had the best performance at a current density of 2 mA/cm2 and an electrode distance of 3 cm. The kinetic analysis showed that the organic pollutant degradation conformed to pseudo-first-order kinetics. The COD removal of the 3D electrode system was more than twice that of the two-dimensional (2D) electrode system, and the energy consumption was 46.56% less than that of the 2D electrode system. By measuring the adsorption capacity and the electrocatalytic ability of the system to produce strong oxidizing species, it was demonstrated that granular activated carbon (GAC) had the synergy of adsorption and electrochemical oxidation, and ·OH playing the dominant role in oxidizing pollutants. At the same time, the organic contaminants adsorbed on GAC could be degraded. Finally, the adsorption–electrochemical oxidation mechanism was proposed. The above results highlighted that the 3D electrode system was a promising alternative method in the application of advanced treatment for WWTPs.
Study on low temperature plasma combined with AC/Mn + TiO2–Al2O3 catalytic treatment of sewage-containing polyacrylamide
Authors: Wang Xiaobing , Guan Fengwei , Huang Zhigang , He Hao , Wang Lu , Li Kaifeng 
Published: February 2023

Abstract
With the introduction of tertiary oil recovery technology, polymer oil drive technology has effectively improved the recovery rate of crude oil, but the resulting oilfield wastewater-containing polyacrylamide (PAM) is viscous and complex in composition, which brings difficulties to wastewater treatment. The treatment of this kind of wastewater has become an urgent problem to be solved, and the removal of PAM is the key. In this paper, a dielectric barrier discharge (DBD) co-catalyst was used to treat PAM-containing solutions to investigate the effect of different catalytic reaction systems on the degradation of PAM. The morphological changes of the PAM solution before and after the reaction were also studied by the environmental electron microscope scanner (ESEM), and the information of the functional groups in the solution before and after the reaction was studied by infrared spectroscopy analysis of the PAM solution. The degradation rate rose by 26.3% in comparison to that without discharge when AC/Mn + TiO2 and Al2O3 were combined and catalyzed at a mass ratio of 2:1 and a discharge period of 300 min. The degradation rate rose by 19.3 and 6.8%, respectively, in comparison to AC/Mn + TiO2 and Al2O3-catalyzed alone. It demonstrates that this catalytic system has the optimum catalytic effect.
Phosphate Prodrugs: An Approach to Improve the Bioavailability of
Clinically Approved Drugs
Authors: Tantra Tanmoy , Singh Yogesh , Patekar Rohan , Kulkarni Swanand , Kumar Pradeep , Thareja Suresh 
Published: February 2023

Abstract:
The phosphate prodrug approach has emerged as a viable option for increasing
the bioavailability of a drug candidate with low hydrophilicity and poor cell membrane
permeability. When a phosphoric acid moiety is attached to the parent drug, it results in a
several-fold elevation in aqueous solubility which helps to achieve desired bioavailability
of the pharmaceutically active parental molecule. The neutral phosphate prodrugs have
rapid diffusion ability through the plasma membrane as compared to their charged counterpart.
The presence of phosphate mono ester breaking alkaline phosphatase (ALP) enzyme
throughout the whole human body, is the main consideration behind the development
of phosphate prodrug strategy. The popularity of this phosphate prodrug strategy is
increasing nowadays due to the fulfillment of different desired pharmacokinetic characteristics
required to get pharmaceutical and therapeutic responses without showing any serious
adverse drug reactions (ADR). This review article mainly focuses on various phosphate
prodrugs synthesized within the last decade to get an improved pharmacological response
of the parent moiety along with various preclinical and clinical challenges associated
with this approach. Emphasis is also given to the chemical mechanism to release the
parent moiety from the prodrug.
Circular RNAs in Prostate Cancer: Is it Time to Further Explore Liquid
Biopsies?
Authors: Yu Jianpeng , Li Hanlin , Shang Zhiqun , Niu Yuanjie 
Published: February 2023

Background:
Although diagnosis and treatment of prostate cancer (PCa) have evolved rapidly
in recent years, clinically significant molecular biomarkers are still needed to lower the mortality.
Circular RNAs (circRNAs) are a poorly characterized component of PCa transcriptome. Recently,
since the development of deep RNA sequencing and novel bioinformatic pipelines, emerging evidence
suggests circRNAs to have diverse functions in the development and progression of PCa. Thus, we
attempt to summarize the current situation and potential development prospects about the role of
circRNAs in PCa liquid biopsies.

Methods:
The role of circRNAs in PCa was summarized by searching the literature related to circRNAs
in PubMed in recent years.

Results:
Deregulation of circRNAs is associated with cell proliferation, apoptosis, cell invasion, migration,
as well as metastasis in PCa. Because of the high stability and tissue specificity of circRNAs,
with improved detection methodologies, circRNAs may be predictive biomarkers in liquid biopsies.

Conclusion:
From the perspective of recent research, with the development of high-throughput sequencing
and novel bioinformatics tools, knowledge of circRNAs will be further expanded. Improved
technologies will make personalized precision medicine less of a paper exercise. It is time to further
explore circRNA in liquid biopsies.
Advances in Ovarian Cancer Treatment Beyond PARP Inhibitors
Authors: Aliyuda Fine , Moschetta Michele , Ghose Aruni , Sofia Rallis Kathrine , Sheriff Matin , Sanchez Elisabet , Rassy Elie , Boussios Stergios 
Published: February 2023

Abstract:
Ovarian cancer has become the largest cause of gynaecological cancer-related mortality. It
is typically diagnosed at a late stage and has no effective screening strategy. Ovarian cancer is a highly
heterogeneous disease that can be subdivided into several molecular subsets. As a result of a greater
understanding of molecular pathways involved in carcinogenesis and tumor growth, targeted agents
have been approved or are in several stages of development. Poly(ADP-ribose) polymerase (PARP)
inhibitors and the anti-vascular endothelial growth factor (VEGF)-A antibodies are two types of approved
and most effective targeted drugs for ovarian cancer at present. With the success of bevacizumab,
tyrosine kinase inhibitors which could target alternate angiogenic pathways are being studied.
Furthermore, many treatments targeting the PI3-kinase (PI3K)/AKT/mammalian target of rapamycin
(mTOR) pathways, are being developed or are already in clinical studies. MicroRNAs have also become
novel biomarkers for the therapy and clinical diagnosis of ovarian cancer. This manuscript reviews
the molecular, preclinical and clinical evidence supporting the targeting of growth-dependent
pathways in ovarian cancer and assesses current data related to targeted treatments beyond PARP inhibitors.
A Lightweight Low-dose PET Image Super-resolution Reconstruction
Method based on Convolutional Neural Network
Authors: Liu Kun , Yu Haiyun , Zhang Mingyang , Zhao Lei , Wang Xianghui , Liu Shuang , Li Haoran , Yang Kun 
Published: February 2023

Background:
PET imaging is one of the most widely used neurological disease screening
and diagnosis techniques.

Aims:
Since PET involves the radiation and tolerance of different people, the improvement that has
always been focused on is to cut down radiation, in the meantime, ensuring that the generated images
with low-dose tracer and generated images with standard-dose tracer have the same details of images.

Methods:
We propose a lightweight low-dose PET super-resolution network (SRPET-Net) based on a
convolutional neural network. In this research, We propose a method for accurately recovering highresolution
(HR) PET images from low-resolution (LR) PET images. The network learns the details and
structure of the image between low-dose PET images and standard-dose PET images and, afterward,
reconstructs the PET image by the trained network model.

Results:
The experiments indicate that the SRPET-Net can achieve a superior peak signal-to-noise
ratio (PSNR) and structural similarity index measurement (SSIM) values. Moreover, our method has
less memory consumption and lower computational cost.

Conclusion:
In our follow-up work, the technology can be applied to medical imaging in many different
directions.
An Approach to Treat Conundrum of Skin Cancer: Bioactive Loaded
Niosomes
Authors: Srivastava Shikha , Sharma Divya 
Published: February 2023

Background:
Skin cancer is one of the most life-threatening and progressive diseases nowadays,
majorly resulting from the cumulative effect of genetic and environmental exposure including
UV rays and numerous pollutants. UV radiation stimulates the excessive generation of Reactive oxygen
species (ROS) and Reactive nitrogen species (RNS), altering numerous signaling and inflammatory
pathways and cumulatively causing alteration at numerous genetic and inflammatory levels. Numerous
treatment strategies have been proposed for this purpose, and it has been found that antioxidants
could play a crucial role in regulating inflammation at certain levels. Among numerous treatment
strategies, natural flavonoid quercetin could play a vital role in protecting cells from oxidative
stress as it is enriched with anticancer, antioxidant, and anti-inflammatory properties. The activities of
quercetin could be further enhanced by administrating it through novel systems.

Objective:
Thus, the present article focuses on the delivery of natural flavonoid quercetin via novel
carrier noisome to enhance targeting potency and safety efficacy.

Method:
Optimized quercetin-loaded niosomes were prepared by mechanical shaking method followed
by solvent evaporation and altering the ratio of cholesterol and span 80. In vitro characterization
was performed for morphology, zeta potential (ZP), entrapment efficiency and drug release.

Result:
The optimized niosome was reported to have a size range of 120 nm, entrapment efficiency
(80%-85%) and followed zero order kinetics.

Conclusion:
Optimized quercetin-loaded niosomes were successfully formulated and characterized
for controlled drug delivery.
Perspectives of Patients With Orthopedic Trauma on Fully Automated Digital Physical Activity Measurement at Home: Cross-sectional Survey Study
Authors: Scherer Julian , Yogarasa Vithush , Rauer Thomas , Pape Hans-Christoph , Heining Sandro-Michael 
Published: February 2023

Background
The automated digital surveillance of physical activity at home after surgical procedures could facilitate the monitoring of postoperative follow-up, reduce costs, and enhance patients’ satisfaction. Data on the willingness of patients with orthopedic trauma to undergo automated home surveillance postoperatively are lacking.

Objective
The aims of this study were to assess whether patients with orthopedic trauma would be generally willing to use the proposed automated digital home surveillance system and determine what advantages and disadvantages the system could bring with it.

Methods
Between June 2021 and October 2021, a survey among outpatients with orthopedic trauma who were treated at a European level 1 trauma center was conducted. The only inclusion criterion was an age of at least 16 years. The paper questionnaire first described the possibility of fully automated movement and motion detection (via cameras or sensors) at home without any action required from the patient. The questionnaire then asked for the participants’ demographics and presented 6 specific questions on the study topic.

Results
In total, we included 201 patients whose mean age was 46.9 (SD 18.6) years. Most of the assessed patients (124/201, 61.7%) were male. Almost half of the patients (83/201, 41.3%) were aged between 30 and 55 years. The most stated occupation was a nine-to-five job (62/199, 30.8%). The majority of the participants (120/201, 59.7%) could imagine using the proposed measurement system, with no significant differences among the genders. An insignificant higher number of younger patients stated that they would use the automated surveillance system. No significant difference was seen among different occupations (P=.41). Significantly more young patients were using smartphones (P=.004) or electronic devices with a camera (P=.008). Less than half of the surveyed patients (95/201, 47.3%) stated that they were using tracking apps. The most stated advantages were fewer physician visits (110/201, 54.7%) and less effort (102/201, 50.7%), whereas the most prevalent disadvantage was the missing physician-patient contact (144/201, 71.6%). Significantly more patients with a part-time job or a nine-to-five job stated that data analysis contributes to medical progress (P=.047).

Conclusions
Most of the assessed participants (120/201, 59.7%) stated that they would use the automated digital measurement system to observe their postoperative follow-up and recovery. The proposed system could be used to reduce costs and ease hospital capacity issues. In order to successfully implement such systems, patients’ concerns must be addressed, and further studies on the feasibility of these systems are needed.
Virtual Reality for Chronic Pain Management Among Historically Marginalized Populations: Systematic Review of Usability Studies
Authors: Dy Marika , Olazo Kristan , Lisker Sarah , Brown Ellenor , Saha Anindita , Weinberg Jessica , Sarkar Urmimala 
Published: February 2023

Background
Virtual reality (VR) has potential to improve chronic pain management outcomes. However, the majority of studies assessing VR are conducted in predominantly White populations in well-resourced settings, thus leaving a gap in knowledge of VR use among diverse populations who experience a significant chronic pain burden.

Objective
This review aims to examine the extent to which usability of VR for chronic pain management has been studied within historically marginalized patient groups.

Methods
We conducted a systematic search to identify studies with usability outcomes located in high-income countries that included a historically marginalized population, defined by a mean age greater than or equal to 65 years, lower educational attainment (greater than or equal to 60% having attained high school education or less), and being a racial or ethnic minority (less than or equal to 50% non-Hispanic White people for studies based in the United States).

Results
Our analysis included 5 papers, which we used to conduct a narrative analysis. Three studies examined VR usability as a primary outcome. All studies assessed VR usability using different measures, of which 4 found VR to be usable by their respective study population. Only 1 study found a significant improvement in pain levels post–VR intervention.

Conclusions
The use of VR shows promise for chronic pain management, but few studies include populations that are older, have limited educational attainment, or have racial or ethnic diversity. Additional studies with these populations are needed to further develop VR systems that work best for diverse patients with chronic pain.