bluuebunny/crossref_metadata_2025_split huggingface dataset:
Removal performance of dissolved organic matters from municipal secondary effluent by different advanced treatment processes and the following disinfection by-products generation rules
Authors: Li Xingyue , Liu Shiqi , Wang Shiqi , Feng Li , Gao Peng , Liu Yongze , Zhang Liqiu 
Published: February 2023

Abstract
Various advanced treatment processes including ultrafiltration (UF), ozonation, enhanced coagulation, and biological aerated filter (BAF) have been applied to reduce dissolved organic matters (DOMs) from the secondary effluent of municipal wastewater treatment plants (MWTPs). In this study, DOMs were characterized and the relationship between DOMs characteristics and DBPs generation was investigated systematically. Results showed that BAF and ozonation processes could significantly affect DOMs characteristics in the treated effluents and the following DBPs generation. UF and enhanced coagulation reduced the production of DBPs by removing large molecular hydrophobic organics. The removal of low molecule DOMs by BAF resulted in a 67.6% reduction in trihalomethanes (THMs) production. Ozonation could oxide large hydrophobic DOMs into small hydrophilic molecules containing aldehyde and ketone groups, leading to 54% increase of chlorinated aldehydes (CHs) and halogenated ketones (HKs). Humic acid (HA) was the main organics type in DOMs and important precursor for THMs and dichloroacetonitrile (DCAN) formation. The generation of trichloromethane (TCM) showed a significant positive correlation (R2 = 0.987) with the specific ultraviolet absorbance at 254 nm (SUVA). Large molecule hydrophobic DOMs devoted the most to the formation of carbonaceous disinfection by-products (C-DBPs) and \(\text{N}{\text{H}}_{\text{4}}^{\text{+}}\)-N content was an important factor affecting the generation of nitrogenous disinfection by-products (N-DBPs). These results are important for the optimization of advanced treatment process in MWTPs, and controlling DBPs should consider the removal of low MW hydrophobic DOMs and the reduction of SUVA.
Development of an international core outcome set for treatment trials in necrotising enterocolitis – A study protocol
Authors: Klerk Daphne , Varsseveld Otis C van , Offringa Martin , Modi Neena , Lacher Martin , Zani Augusto , Pakarinen Mikko P , Koivusalo Antti , Jester Ingo , Spruce Marie , Derikx Joep PM , Bakx Roel , Ksia Amine , Vermeulen Marijn J , Kooi Elisabeth MW , Hulscher Jan BF 
Published: February 2023

Abstract
Aim: Necrotising Enterocolitis (NEC) is the most lethal disease of the gastrointestinal tract of preterm infants. New and existing management strategies need clinical evaluation. Large heterogeneity exists in the selection, measurement, and reporting of outcome measures in NEC intervention studies. This hampers meta-analyses and the development of evidence-based management guidelines. We aim to develop a Core Outcome Set (COS) for NEC that includes the most relevant outcomes for patients and physicians, from moment of diagnosis into adulthood. This COS is designed for use in NEC treatment trials, in infants with confirmed NEC.
Methods: This study is designed according to COS-STAD (Core Outcome Set-STAndards for Development) recommendations and the COMET (Core Outcome Measures in Effectiveness Trials) Initiative Handbook. We obtained a waiver from the Ethics Review Board and prospectively registered this study with COMET (Study 1920). We will approach 125 clinicians and/or researchers from low-middle and high-income countries based on their scientific output (using SCIVAL, a bibliometric tool). Patients and parents will be approached through local patient organisations. Participants will be separated into three panels, to assess differences in priorities between former patients and parents (1. lay panel), clinicians and researchers involved in the neonatal period (2. neonatal panel) and after the neonatal period (3. post-neonatal panel). They will be presented with outcomes currently used in NEC research, identified through a systematic review, in a Delphi process. Eligible outcome domains are also identified from the patients and parents’ perspectives. Using a consensus process, including three online Delphi rounds and a final face-to-face consensus meeting, the COS will be finalized and include outcomes deemed essential to all stakeholders: health care professionals, parents and patients’ representatives. The final COS will be reported in accordance with the COS-Standards for reporting (COS-STAR) statement.
Conclusions: Development of an international COS will help to improve homogeneity of outcome measure reporting in NEC, will enable adequate and efficient comparison of treatment strategies, and help the interpretation and implementation of clinical trial results. This will contribute to high-quality evidence regarding the best treatment strategy for NEC in preterm infants.
Establishment and characterization of the first Cuvier's Beaked whale (Ziphius cavirostris) in vitro model based on the muscle-derived cell line
Authors: Peruffo Antonella , Bassan Irene , Corain Livio , Otero-Sabio Cristina , Giacomello Marta , Centelleghe Cinzia 
Published: February 2023

Abstract
In this study we present for the first time, an in vitro model based on a muscle-derived cell line from a Cuvier's Beaked whale male. This cell line represents a new opportunity to testing toxic effects of water pollutants, in Cuvier's Beaked living cells.
Cell line characterization included karyotyping, assessment of growth rate and ultrastructural analysis. The population doubling time was determined to be ~54 h. The karyotype analysis revealed the presence chromosomes pairs 2n = 42. Immunohistochemical studies showed that cells express actin, vimentin and desmin. This cell line, represents a new opportunity to understand the physiological of the Ziphius cells and provide a novel in vitromodel to investigate alterations due to waters pollutants.
Clinical characteristics and homology analysis of Staphylococcus aureus from would infection at a tertiary hospital in southern Zhejiang, China
Authors: Jin Xiaoya , Zhang Jiarong , Tu Jingjing , Chen Yongpin 
Published: February 2023

Abstract
Objective
Staphylococcus aureus (S. aureus), especially Methicillin resistant S. aureus (MRSA), has been disseminated across communities and hospitals, associated with severe infections and organ failure. In order to understand the clinical epidemiological characteristics of S. aureus stains in the first affiliated Hospital of Wenzhou Medical University in 2018, the prevalence and the drug resistance of S. aureus stains were investigated, for improving the clinical effective prevention and control of S. aureus infection.
Methods
A total of 105 S. aureus isolates were separated from wound infection of inpatients in the first affiliated Hospital of Wenzhou Medical University in 2018, and the department distributions and drug resistance of the isolates were analyzed. The genotyping homology analysis was conducted through the random amplified polymorphic DNA typing (RAPD-PCR) coupled with NTSYS cluster analysis.
Results
Among the 105 strains of S. aureus, 31 isolates were MRSA. The prevalence of MRSA among inpatients in the departments of burn, trauma, orthopedics, nephrology and neurosurgery were 35.48%, 19.35%, 9.68%, 6.45%, and 29.03%, respectively. Among the 105 strains, 35.24% strains were the hospital-acquired infections (HAI) and 64.76% strains were community-acquired infections (CAI). Random amplified polymorphic DNA genotyping of the 105 S. aureus strains showed seventeen different groups, most of which were type I, type VII, type IX, and type VII, the others were scattered.
Conclusion
The clinical characteristics of the 105 S. aureus between MRSA and MSSA strains differed significantly in the first affiliated Hospital of Wenzhou Medical University in 2018. In order to curb the nosocomial infection and protect the susceptible populations, it is vital for us to the monitor, prevention and control for the S. aureus infection and transmission in the nosocomial settings. The observations from the study would improve our management of disinfection and sterilization measures, and provide guidance for clinical medication.
Robotic Pendant Drop: Containerless Liquid for μs-resolved, AI-executable XPCS
Authors: Ozgulbas Doga , Jensen Don , Irvin Michael , Nakaye Yasukazu , Dufresne Eric , Seifert Soenke , Babnigg Gyorgy , Ramanathan Arvind , Zhang Qingteng 
Published: February 2023

Abstract
X-ray Photon Correlation Spectroscopy (XPCS) probes the spontaneous fluctuation in spatial configurations of mixed phases, which can significantly impact the material properties of complex fluid. Tailored material design, however, requires navigation through massive multi-dimensional parameter space which is beyond the bandwidth of current XPCS beamline infrastructure. Using 3.7 μs-resolved XPCS, we demonstrate that Brownian dynamics of silica colloidal nanoparticles in a shielded pendant drop suspended from an electronic pipette is consistent with a sealed capillary, validating the use of pendant drop for automated XPCS measurement. Furthermore, the electronic pipette can be mounted on a robotic arm to access different stock solutions and create samples with highly-repeatable and precisely-controlled composition profiles (Video S2). This closed-loop, AI-executable experimental protocol is the first step towards autonomous material discovery and is applicable for not only XPCS, but also other high-throughput light and x-ray scattering techniques for multimodal, collaborative material characterization.
Attitudes of Physiotherapy Students Towards Playing Physical Activity Games
Authors: KARAALI Hayriye KUL , ozcan ozlem 
Published: February 2023

Abstract
Background
Physiotherapists show a positive attitude towards playing games in order to be a role model for pediatric patients and increase the success of therapy. The aim of study is to evaluate the attitudes of students in Physiotherapy and Rehabilitation department towards playing games that contain physical activity.
Methods
The sociodemographic data, students’ regular physical activity habits as well as their computer game playing status and duration were examined. “Attitudes of 18–22 Age Adults for Playing Games That Contain Physical Activity” scale was used for assessing game proneness.
Results
A total of 268 students participated in the study. Among the game proneness scale sub-sections, while the highest score was obtained in the Social Adjustment, the lowest scores were obtained in the "Desire to Play Game" and "To take pleasure from playing game" sub-sections. Males scored higher in “Risk Taking and “to take pleasure from playing game” in comparison with the female students. There was a statistically significant difference between physical activity habits and Game Compassion, Risk Taking, Social Adjustment and to take pleasure from playing game scores.
Conclusion
The present study suggest that monitoring female and non-physical students during undergraduate education might be beneficial for evaluating their attitude towards playing games.
Examining the association between functional social support, marital status, and memory: A systematic review
Authors: Haghighi Paniz , Oremus Mark 
Published: February 2023

Abstract
Background: Functional social support (FSS) has been shown to be positively associated with better cognitive function, especially memory, in cross-sectional and longitudinal studies. To better understand this complex association, researchers should consider the impact of additional factors that affect both FSS and memory. Therefore, we conducted a systematic review to examine whether one such factor, marital status or related variables (e.g., FSS from spouses compared to FSS from relatives or friends), affects (e.g., confounds or modifies) the association between FSS and memory in middle-aged and older adults.
Methods: We searched PubMed, PsycINFO, and Scopus from database inception to June 2022. Eligible articles examined the association between FSS and memory, and included marital status or related variables in the analysis. Data were synthesized narratively using the Synthesis without meta-analysis (SWiM) guidelines and risk of bias was assessed using the Newcastle-Ottawa Scale (NOS).
Results: Four articles were included in the narrative synthesis. All four articles had a low risk of bias. Overall findings suggested some positive associations between FSS from a spouse/partner and memory; however, effect sizes were small and similar to other sources of support, including children, relatives, and friends.
Conclusions: Our review is the first attempt to synthesize the literature on this topic. Despite theoretical support for examining the impact of marital status or related variables on the association between FSS and memory, published studies explored this issue secondarily to other research questions.
Maternal pregnancy-related anxiety and offspring physical growth in childhood: the Ma’anshan birth cohort study
Authors: Zhou Jixing , Zhang Shanshan , Teng Yuzhu , Lu Jingru , Guo Yufan , Yan Shuangqin , Tao Fangbiao , Huang Kun 
Published: February 2023

Abstract
Background: Epidemiological studies have identified maternal antenatal anxiety and adverse birth outcomes, but absence of epidemiological studies has examined the relationship with long term physical growth in children.
Methods: 3,154 mother-child pairs were included based the Ma’anshan birth cohort study. Maternal prenatal anxiety was obtained by administering a questionnaire using the pregnancy-related anxiety questionnaire (PRAQ) scale during the 1st, 2nd and 3rd trimester. Body fat (BF) and body mass index (BMI) were collected on children from birth to 72 months. Group-based trajectory models were applied to fit the different trajectories of BMI and BF.
Results: Maternal anxiety in the 2nd (OR = 0.81; 95% CI: 0.68 to 0.98) and 3rd (OR = 0.82; 95% CI: 0.68 to 0.98) trimester was associated with a decreased risk of RWG in the first year of life. Children aged at 48 to72 months of mothers with anxiety in the 3rd trimester had lower BMI (β = -0.145; 95% CI, -0.279 to -0.011) and BF (β = -0.194; 95% CI, -0.340 to -0.048), and these children were less likely to develop a very high BMI trajectory (OR = 0.59; 95% CI: 0.37 to 0.93), and a high BF trajectory (OR = 0.71; 95% CI: 0.52 to 0.98). A similar association was found between maternal anxiety simultaneously in the 2nd and 3rd trimesters and child physical growth.
Conclusions: Maternal prenatal anxiety in the 2nd and 3rd trimester may decrease weight status in preschool-aged children, which may be related to reduced weight gain in infancy resulting in.
Genome-wide association mapping of resistance to the foliar diseases septoria nodorum blotch and tan spot in a global winter wheat collection
Authors: Haugrud Amanda R. Peters , Shi Gongjun , Seneviratne Sudeshi , Running Katherine L.D. , Zhang Zengcui , Singh Gurminder , Szabo-Hever Agnes , Acharya Krishna , Friesen Timothy L. , Liu Zhaohui , Faris Justin D. 
Published: February 2023

Abstract
Septoria nodorum blotch (SNB) and tan spot, caused by the necrotrophic fungal pathogens Parastagonospora nodorum and Pyrenophora tritici-repentis, respectively, often occur together as a leaf spotting disease complex on wheat (Triticum aestivum L.). Both pathogens produce necrotrophic effectors (NEs) that contribute to the development of disease. Here, genome-wide association analysis of a diverse panel of 264 winter wheat lines revealed novel loci on chromosomes 5A and 5B associated with sensitivity to the NEs SnTox3 and SnTox5 in addition to the known sensitivity genes for NEs Ptr/SnToxA, SnTox1, SnTox3, and SnTox5. Sensitivity loci for SnTox267 and Ptr ToxB were not detected. Evaluation of the panel with five P. nodorum isolates for SNB development indicated the Snn3-SnTox3 and Tsn1-SnToxA interactions played significant roles in disease development along with additional QTL on chromosomes 2A and 2D, which may correspond to the Snn7-SnTox267 interaction. For tan spot, the Tsc1-Ptr ToxC interaction was associated with disease caused by two isolates, and a novel QTL on chromosome 7D was associated with a third isolate. The Tsn1-ToxA interaction was associated with SNB but not tan spot. Therefore some, but not all, of the previously characterized host gene-NE interactions in these pathosystems play significant roles in disease development in winter wheat. Based on these results, breeders should prioritize the selection of resistance alleles at the Tsc1, Tsn1, Snn3, and Snn7 loci as well as the 2A and 7D QTL to obtain good levels of resistance to SNB and tan spot in winter wheat.
Etiological analysis of patients with sudden sensorineural hearing loss: a prospective case-control study
Authors: Xie Wen , Karpeta Niki , Tong Busheng , Liu Jiali , Peng Haisen , Li Chunhua , Hellstrom Sten , Liu Yuehui , Duan Maoli 
Published: February 2023

Abstract
Sudden sensorineural hearing loss (SSNHL) is a multifactorial emergency disease. Until now, the etiology of SSNHL is still unknown. Previous studies regarding the etiology of SSNHL are clinical studies depending on clinical data collection and analysis. Due to the insufficient sample size or various selective bias in clinical studies, the results of these studies may be inaccurate. This prospective case-control study aimed at exploring the possible etiology and risk factors of SSNHL. We enrolled 255 SSNHL patients and 255 sex-, age- and residence- matched non-SSNHL subjects in the control group. Our study shows that there was no significant difference in the prevalence of comorbidities including hypertension and diabetes, as well as the incidence of smoking and drinking habits between the case and control groups (P > 0.05). In addition, the peripheral blood white blood cell count, neutrophil count, platelet-to-lymphocyte ratio (PLR) and fibrinogen level of the case group were significantly higher than those in the control group (P < 0.05). These findings suggest smoking, drinking, hypertension and diabetes may not be related to the onset of SSNHL. However, hypercoagulable state and inner ear vascular microthrombosis related to an elevated fibrinogen level might be the risk factors of the disease. In addition, inflammation play an important role of SSNHL onset. Trial Registration Chinese Clinical Trial Registry. Registration number: ChiCTR2100048991
Fine root turnover and longevity and their responses to nitrogen fertilization of nitrogen-fixing and non-nitrogen-fixing tree species
Authors: Fan Jie , Song Lihao , xu Lihua , Zeng huihui , Liu Licheng , Zhao Zeyao , Chen Tong , Fang Yanni , Mei Li 
Published: February 2023

Abstract
Background and aims
Fine root longevity and turnover respond to changes in soil nitrogen (N) determine plants’ performance at elevated N-level under global N-deposition. This study was conducted to understand the fine root dynamics of N-fixing and non-N-fixing tree species at elevated N-level by N fertilization.
Methods
To determine fine root dynamics (biomass, length density, longevity, and turnover rate) under N-fertilization, a three-year fertilization experiment at 150 g CO(NH2)2. m− 2 year− 1 was conducted for two N-fixing species and two non-N-fixing tree species.
Results
Fine root biomass of the two N-fixing tree species was lower than that of non-N-fixing tree species. N-fertilization decreased root length density, root surface area, and root volume of all tree species. The fine root turnover rate of N-fixing trees was higher but root longevity was lower than that of non-N-fixing species. For all four species, N fertilization decreased fine root turnover rate but increased fine root longevity. Moreover, both the root turnover rate and root longevity of the two N-fixing tree species were more sensitive than the two non-N-fixing tree species to N fertilization. The proportion of long-lived roots of non-N-fixing tree species was higher than that of N-fixing tree species.
Conclusion
Fine roots of N-fixing tree species have shorter longevity and faster turnover rate than that of non-N-fixing tree species. The fine root longevity and turnover of N-fixing tree species were more sensitive to elevated N-level than that of non-N-fixing species at elevated N-level, they have different response strategies to the increase of soil N.
Relationship between alexithymia, loneliness, resilience and non- suicidal self-injury in adolescents with depression: a multi-center study
Authors: zhang bing , chen yang , fu wenxian , jiang cheng , Zhou Yongjie , He Kongliang 
Published: February 2023

Abstract
Objective
Non-suicidal self-injury (NSSI) behaviors are prevalent in adolescents and have adverse effects on physical and mental health. However, little is known about the relationship between NSSI and alexithymia, or the underlying mechanisms that could explain this relationship. This study aimed to elucidate the current status of NSSI in adolescent depression, and analyze the relationship between alexithymia, loneliness, resilience, and adolescent depression with NSSI, so as to provide a theoretical basis for psychotherapeutic interventions.
Method
The study sample involved inpatients and outpatients from 12 hospitals across China and adolescents with depression who met the DSM-5 diagnostic criteria for depression episode. The following scales were used: The Functional Assessment of Self-Mutilation, Toronto Alexithymia Scale, UCLA Loneliness Scale, and Connor Davidson Resilience Scale.
Results
The detection rate of NSSI in adolescents with depression from 2021.01.01-2022.01.01 was 76.06% (1782/2343). Spearman's correlation analysis revealed a significant correlation between alexithymia, loneliness, resilience and NSSI in depressed adolescents, the results of the independent samples t-test showed that the differences between the two groups for each factor were statistically significant. Binary logistic regression results showed that alexithymia (B = 0.023, p = 0.003, OR = 1.023, 95% CI: 1.008–1.038) and depression (B = 0.045, p < 0.001, OR = 1.046, 95% CI: 1.026–1.066) are risk factors for NSSI, resilience (B = − 0.052, p < 0.001, OR = 0.949, 95% CI: 0.935 − 0.964) is a protective factor for NSSI. Alexithymia directly predicted NSSI and also indirectly influenced NSSI through the mediated effect of resilience. Loneliness moderates the first half of the path of this mediated model.
Conclusion
The data from this study provide evidence for the mediating effect of resilience between alexithymia and NSSI, as well as evidence that loneliness can moderate the first segment of the pathway in this moderated mediation model. We discuss perspectives for future research and interventions based on the findings of the study.