bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting self-harm at one year in female prisoners: a retrospective cohort study using machine learning
Authors: Tiffin Paul A , Leelamanthep Sant , Paton Lewis W , Perry Amanda E. 
Published: September 2023

AbstractBackgroundSelf-harm and suicide are relatively overrepresented in incarcerated populations, especially in female prisons. Identifying those most at risk of significant self-harm could provide opportunities for effective, targeted interventions.AimsTo develop and validate a machine learning-based algorithm capable of achieving a clinically useful level of accuracy when predicting the risk of self-harm in female prisoners.MethodData were available on 31 variables for 286 female prisoners from a single UK-based prison. This included sociodemographic factors, nature of the index offence, and responses to several psychometric assessment tools used at baseline. At 12-month follow-up any self-harm incidents were reported. A machine learning algorithm (CatBoost) to predict self-harm at one-year was developed and tested. To quantify uncertainty about the accuracy of the algorithm, the model building and evaluation process was repeated 2000 times and the distribution of results summarised.ResultsThe mean Area Under the Curve (AUC) for the model on unseen (validation) data was 0.92 (SD 0.04). Sensitivity was 0.83 (SD 0.07), specificity 0.94 (SD 0.03), positive predictive value 0.78 (SD 0.08) and the negative predictive value 0.95 (0.02). If the algorithm was used in this population, for every 100 women screened, this would equate to approximately 17 ‘true positives’ and five ‘false positives’.ConclusionsThe accuracy of the algorithm was superior to those previously reported for predicting future self-harm in general and prison populations and likely to provide clinically useful levels of prediction. Research is needed to evaluate the feasibility of implementing this approach in a prison setting.
Exploring consumer preferences for cannabis edible products to support public health policy: A discrete choice experiment
Authors: Donnan Jennifer R. , Johnston Karissa , Coombs Michael , Najafizada Maisam , Bishop Lisa D. 
Published: September 2023

AbstractBackgroundIn October 2019, cannabis edibles were legalized for sale in Canada. This move was intended to improve public safety by regulating contents (including a maximum 10 mg tetrahydrocannabinol (THC) per package) and packaging to prevent accidental ingestion or over consumption. This study aimed to explore consumer preferences for cannabis edibles to inform cannabis policy.MethodsWe explored the relative importance and trade-offs consumers make for attributes of cannabis edibles using a discrete choice experiment. Attributes included type of edible, price, THC content, cannabis taste, package information, product consistency, product recommendations, and Health Canada regulation. Participants lived in Canada, were 19 years of age or older, and purchased a cannabis edible in the last 12 months. A multinomial logit (MNL) model was used for the base model, and latent class analysis to assess preference sub-groups.ResultsAmong 684 participants, the MNL model showed that potency was the most relevant followed by edible type. A two-group latent class model revealed two very distinct preference patterns. Preferences for group 1 (∼65% of sample) were driven primarily by edible type, while for group 2 (∼35% of sample) were driven almost entirely by THC potency.ConclusionThis study found that consumer preferences for ∼65% of consumers of cannabis edibles are being met through regulated channels. The remaining ∼35% are driven by THC potency at levels that are not currently available on the licensed market. Attracting this market segment will require reviewing the risks and benefits of restricting THC package content.
Endogenous glucagon-like peptide 1 diminishes prandial glucose counterregulatory response to hypoglycemia after gastric bypass surgery
Authors: Honka Henri , Gastaldelli Amalia , Pezzica Samantha , Peterson Richard , DeFronzo Ralph , Salehi Marzieh 
Published: September 2023

ABSTRACTWe have previously shown that prandial endogenous glucose production (EGP) during insulin-induced hypoglycemia is smaller in non-diabetic subjects with gastric bypass (GB), where prandial glucagon-like peptide 1 (GLP-1) concentrations are 5-10 times higher than those in non-operated controls. Here, we sought to determine the effect ofendogenousGLP-1 on prandial counterregulatory response to hypoglycemia after GB. Glucose fluxes, and islet-cell and gut hormone responses before and after mixed-meal ingestion were compared during a hyperinsulinemic hypoglycemic (∽3.2 mmol/l) clamp with and without a GLP-1 receptor (GLP-1R) antagonist exendin-(9-39) (Ex-9) in non-diabetic subjects with prior GB compared to matched subjects with SG and non-surgical controls. In this setting, GLP-1R blockade had no effect on insulin secretion or insulin action, whereas prandial glucagon was enhanced in all 3 groups. Ex-9 infusion raised prandialEGPresponse to hypoglycemia in every GB subject but had no consistent effects on EGP among subjects with SG or non-operated controls (P< 0.05 for interaction). These results indicate that impaired post-meal glucose counterregulatory response to hypoglycemia after GB is partly mediated by endogenous GLP-1, highlighting a novel mechanism of action of GLP-1R antagonists for the treatment of prandial hypoglycemia in this population.
Corpus callosum abnormalities at term-equivalent age are associated with language development at two years corrected age in infants born very preterm
Authors: Kojima Katsuaki , Kline Julia E , Altaye Mekibib , Kline-Fath Beth M , Parikh Nehal A ,   the Cincinnati Infant Neurodevelopment Early Prediction Study (CINEPS) Investigators
Published: September 2023

ABSTRACTWe studied the impact of microstructural abnormalities in the corpus callosum on language development in 348 infants born very prematurely. We discovered that the fractional anisotropy of the corpus callosum anterior midbody was a significant predictor of standardized language scores at two years, independent of clinical and social risk factors.
Occupational Health Management in New Work – a Protocol for a Mixed-Method Study: Project BGM4NewWork
Authors: Rinne Carla , Niebuhr Fiona , Wawera Anna-Sophia , Voelter-Mahlknecht Susanne 
Published: September 2023

AbstractBackgroundThe world of work is undergoing profound changes towards agile, flexible, democratic, and digital forms of work, so calledNew Work(NW). The COVID-19 pandemic accelerated these changes and confronted the working world with new challenges. Effects on employee health are ambivalent and remain unclear. Moreover, there is a lack of evidence as to whether existing occupational health management (OHM) measures meet the needs of employees working in new forms of work.Methods/DesignThis prospective mixed-method project will include four substudies to identify different NW forms, resulting health risk, benefits and protective factors in subgroups, and derive target group-specific OHM services. In the four substudies, the following methods will be used: (1) a scoping review, semi-standardized interviews, and an online survey, (2) a systematic review, an online survey, an expert workshop and qualitative interviews, (3) workplace observations, and (4) expert workshops. Recommendations for action will be derived from the findings of all substudies and summarized in a checklist for OHM in NW settings.ConclusionFindings will expand the state of knowledge about NW settings and associated health effects. The development of an evidence-based checklist for target group-specific identification of NW settings and associated health risks, benefits and protective factors can be used as a basis for action regarding OHM in companies. The findings can provide guidance on how future OHM services should be designed to meet the needs of employees.
PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency
Authors: Crespo Raquel , Ne Enrico , Reinders Julian , Meier Jenny I. J. , Li Chengcheng , Jansen Sanne , Górska Alicja , Koçer Selin , Kan Tsung Wai , Doff Wouter , Dekkers Dick , Demmers Jeroen , Palstra Robert-Jan , Rao Shringar , Mahmoudi Tokameh 
Published: September 2023

SummaryHIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. To elucidate the molecular players that govern latency, we previously performed a dCas9-chromatin immunoprecipitation coupled with mass spectrometry (Catchet-MS) and identified the interactome of the latent HIV-1 LTR. Here we characterize the Catchet-MS-identified PCI domain-containing 2 (PCID2) protein, a component of the TREX2 complex, to play a dual role in promoting HIV-1 latency by enforcing both transcriptional repression and post-transcriptional blocks to HIV-1 gene expression. PCID2 bound the latent HIV-1 LTR and repressed transcription initiation during latency. Depletion of PCID2 remodelled the chromatin landscape at the HIV-1 promoter and resulted in transcriptional activation and reversal of latency. Immunoprecipitation coupled to Mass Spectrometry identified PCID2-interacting proteins to include members of the spliceosome, including negative viral RNA (vRNA) alternative splicing regulators, and PCID2 depletion resulted in over-splicing of intron-containing vRNA and misregulated expression of vRNA splice variants. We demonstrate that MCM3AP and DSS1, two other RNA-binding TREX2 complex subunits that comprise the dock of the complex also inhibit transcription initiation and viral RNA alternative splicing during latency and similarly to PCID2 function as prominent latency associated repressors of HIV-1 gene expression. Thus, PCID2 is a novel HIV-1 latency-promoting factor, which in context of the TREX2 sub-complex PCID2-DSS1-MCM3AP blocks transcription and dysregulates vRNA processing.
Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation
Authors: Sahoo Bikash R. , Kocman Vojč , Clark Nathan , Myers Nikhil , Deng Xiexiong , Wong Ee L. , Yang Harry J. , Kotar Anita , Guzman Bryan B. , Dominguez Daniel , Plavec Janez , Bardwell James C.A. 
Published: September 2023

ABSTRACTThe SERF family of proteins were originally discovered for their ability to accelerate amyloid formation. Znf706 is an uncharacterized protein whose N-terminus is homologous to SERF proteins. We show here that human Znf706 can promote protein aggregation and amyloid formation. Unexpectedly, Znf706 specifically interacts with stable, non-canonical nucleic acid structures known as G-quadruplexes. G-quadruplexes can affect gene regulation and suppress protein aggregation; however, it is unknown if and how these two activities are linked. We find Znf706 binds preferentially to parallel G-quadruplexes with low micromolar affinity, primarily using its N-terminus, and upon interaction, its dynamics are constrained. G-quadruplex binding suppresses Znf706’s ability to promote protein aggregation. Znf706 in conjunction with G-quadruplexes therefore may play a role in regulating protein folding. RNAseq analysis shows that Znf706 depletion specifically impacts the mRNA abundance of genes that are predicted to contain high G-quadruplex density. Our studies give insight into how proteins and G-quadruplexes interact, and how these interactions affect both partners and lead to the modulation of protein aggregation and cellular mRNA levels. These observations suggest that the SERF family of proteins, in conjunction with G-quadruplexes, may have a broader role in regulating protein folding and gene expression than previously appreciated.
Research on the impact of the application of artificial intelligence technology on the sustainable development of mobile e-commerce
Authors: Deng Zhihang , Guo Meiwen 
Published: September 2023

PurposeThis article aims to reveal the factors influencing the sustainable development of mobile e-commerce from both user and operational perspectives. It fills the gap in qualitative research on the sustainable development of artificial intelligence (AI) technology in mobile e-commerce based on the grounded theory. This study provides valuable insights and inspiration for sustainable development in this field and lays the theoretical foundation and research reference for future studies.Design/methodology/approachBased on the grounded theory (GT), interview method was used to conduct the study.FindingsThe impact of AI applications on mobile e-commerce is mainly reflected in three stages of the customer shopping process. They are pre-shopping, mid-shopping and after-shopping AI services and each of the three stages has its own separate dimensions that need attention. The study and its persistence aspects are discussed.Practical implicationsThe results of this study can provide forward-looking suggestions and paths for the construction and optimization of future e-commerce platforms, contribute to the sustainable development of e-commerce and contribute to the sustainable and healthy growth of the social economy.Originality/valueThis study proposes sustainable development measures for the application of AI in mobile e-commerce, from operation to supervision, which is an important reference for promoting coordinated and rapid socio-economic development.
Significance of quality higher education in the advancement of gender equality: the case of Bangladesh
Authors: Alam Md Jahangir , Ogawa Keiichi , Basharat Lubaba , Ahsan Abu Hossain Muhammad 
Published: September 2023

PurposeThis research has been conducted to determine the core reasons for gender inequality and to evaluate the effectiveness of higher education as a sole solution to ensure gender equality.Design/methodology/approachThis qualitative case study research explores the causes behind gender inequality, and interviews were conducted with 20 male and female graduates and five stakeholders. Liberal feminism theory has been employed to understand the phenomena.FindingsThe findings show that receiving a university degree cannot ensure gender equality and empowerment of women in Bangladesh. The key factors contributing to gender disparity are societal and a general deficiency of technical knowledge.Practical implicationsMore policies should support women in every aspect of life, and the existing policies should be carefully followed. The government must ensure high-quality education, and people must show more significant concern by acquiring knowledge from quality education seeking gender equality.Originality/valueThis research fills the gap in the current literature by providing knowledge about the practical effectiveness of quality higher education in solving the problem of gender inequality, its core reasons and possible solutions in Bangladesh's context.
Investigating the role of internal security resources in post-adoption satisfaction with the Security-as-a-Service model: an organizational mindfulness perspective
Authors: Vedadi Ali , Brooks Nita , Greer Tim 
Published: September 2023

PurposeMany organizations struggle to utilize security-as-a-service (SecaaS) advantages effectively, thus challenging the assumption that adopting the SecaaS model will necessarily lead to post-adoption satisfaction. This research paper draws on the organizational mindfulness theory and investigates the factors that lead to satisfaction with SecaaS.Design/methodology/approachThe key informant-based survey approach was employed to collect data from 215 organizations that were using the SecaaS model. PLS was used for data analysis.FindingsOrganizations with greater extents of internal security resources report higher satisfaction levels with SecaaS, thanks to the mediating effect of organizational mindfulness, and that organizations with extensive and mature security auditing were especially well-positioned to experience satisfaction with SecaaS.Originality/valueThis research provides new theoretical insights into the conditions under which organizations' post-adoption satisfaction with the SecaaS model is shaped by investigating the role of internal security resources and organizational mindfulness.
All things must pass? Introduction to the special issue on post-Covid place marketing
Authors: Warnaby Gary , Medway Dominic , Byrom John 
Published: September 2023

Purpose
The purpose of this introductory paper is to outline the theme of – and introduces the papers comprising – this special issue on post-Covid place marketing.

Design/methodology/approach
A brief literature review outlines some of the impacts of the COVID-19 pandemic on places and also for place-bound and spatially oriented industry sectors (particularly retailing and tourism and hospitality, which are often the focus of place marketing initiatives) before describing the papers constituting the special issue.

Findings
The impacts of the COVID-19 pandemic on places are identified, relating to both economic and more phenomenologically oriented impacts, and the implications for place resilience are considered. The papers comprising the special issue are grouped into two main themes relating to the impact of the COVID-19 pandemic on retailing and the impact of the pandemic on place marketing processes.

Originality/value
Notwithstanding the burgeoning literature on the COVID-19 pandemic and its impacts, the papers comprising this special issue focus on specific place-oriented marketing (and retailing) implications, providing potential avenues for future research.
Employee goal orientation and knowledge sharing: the moderating effect of leader boundary spanning behavior
Authors: Kim Myungsun , Kim Seckyoung Loretta 
Published: September 2023

PurposeThe research aims to examine the impacts of two different types of goal orientation, i.e. leaning goal orientation (LGO) and performance-prove goal orientation (PPGO), on employee knowledge sharing, and whether these relationships are altered by leaders' boundary spanning behavior (BSB).Design/methodology/approachA sample of 170 employees and 93 leaders were collected from South Korean organizations. Data were analyzed using path analysis.FindingsThe results demonstrated that employees with a high LGO are more likely to engage in knowledge sharing, while employees with a high PPGO are less likely to show knowledge sharing. Moreover, the findings showed that highly learning oriented employees tend to engage in knowledge sharing when they are under leaders who show active BSB.Practical implicationsTo encourage knowledge sharing between employees, organizations need to promote a mastery-structured work environment to help employees develop a stronger LGO. Also, organizations could benefit from implementing training programs for leaders that promote their BSB.Originality/valueThe research aims to provide a more articulate account for how LGO and PPGO affect employee knowledge sharing in opposite ways. More importantly, this research provides new insights regarding the role of leaders' BSB as a contextual factor in promoting employee knowledge sharing. Using social learning theory as a theoretical framework, this study indicates how employees with a high LGO learn the behaviors of boundary spanning leaders and are more willing to engage in knowledge sharing.
Insight from industry: Moet Hennessy’s development of an innovative supplier diversity program in the wine and beverage industry
Authors: van Hoek Remko , Lebigot Dominique , Bagot Antoine , Sexton Shannon 
Published: September 2023

Purpose
Supplier diversity has roots in US supply chains going back 50  years. Unfortunately, supplier diversity programs have been hindered by less than wholehearted buyer adoption and stakeholder engagement. The original scoping of supplier diversity also holds limitations when comparing to the multidimensionality of the diversity and inclusion concept. The purpose of this article is to share lessons learned from the development of an innovative supplier diversity program by Moet Hennessy aimed at more sustainably scoping, scaling and stimulating supplier diversity programs.

Design/methodology/approach
The development and the design of Moet Hennessy’s supplier diversity program is presented. The design was informed, and partially supported by, a collaboration with the author. Critical reflections on pitfalls and outstanding questions are developed based upon the program design.

Findings
Moet Hennessy developed a supplier diversity program that is more comprehensively defined, targets a more global scale and includes innovative stakeholder engagement techniques such as the development of supplier diversity champions in the business. The program also is embedded in existing environmental social and governance initiatives.

Originality/value
Moet Hennessy’s supplier diversity program was not mandated by one of its customers but sourced from an academic collaboration and stimulated by competitive opportunity. The program was designed bottoms up, not top down. The program is sponsored outside of procurement and has champions throughout the business. The program expands beyond the traditional scoping of supplier diversity programs. Pathways and pitfalls for managers are identified based upon insights from Moet Hennessy’s experience. These inform suggestions for further research.
Plastic warriors: a study on self-help group’s contribution to economic, social value creation and sustainable development goals (SDGs) in Tamil Nadu, India
Authors: Jayakumar M. Dominic , Ramasundaram Aiswarya , Vanathayan Arokiyadass 
Published: September 2023

Purpose
Solid, liquid and e-waste pose serious health hazards, environmental pollution and contribute to climate change. To address these issues of solid waste management (SWM), amidst many policy decisions, the Government of India roped in several institutions, including self-help groups (SHGs), into the Swachh Bharat Movement (Clean India Mission). This study aims to illustrate the significant contributions of SHG’s in tackling SWM, particularly the plastic waste menace in India, while fostering socio-economic values and sustainable development goals (SDGs).

Design/methodology/approach
Using a from-the-field approach, qualitative data were collected from 30 members of three SHGs to understand their significant contributions in mitigating plastic waste.

Findings
This research identifies three major themes: economic value creation, social value creation and SDGs via collection and reduction of plastic waste landfills. Furthermore, several related subthemes are identified.

Practical implications
This study offers pragmatic solutions to deal with plastic waste at personal, community, institutional and governmental levels. Moreover, it recommends engaging SHGs to promote sustainable waste management practices such as segregating wastes at source, regulating plastic bag usage, advocating behavioural change towards waste generation and protecting the environment.

Originality/value
The authors consider a proven case of SHG’s contribution to protect the environment and emphasize the need to involve more such groups in waste management practices.