bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying pain and distress in non-verbal persons with intellectual disability: Professional caregivers’ and parents’ attitudes towards using wearable sensors
Authors: Øderud Tone , Boysen Elin S. , Strisland Frode , Dahl Inger-Lise , Kildal Emilie , Hassel Bjørnar , Morland Cecilie 
Published: August 2023

BACKGROUND: Persons with severe intellectual disability (ID) may be non-verbal and unable to communicate pain or distress. Consequently, painful conditions may go undetected, and non-verbal persons with ID may not receive adequate care and treatment. OBJECTIVE: This study aims to explore how professional caregivers and parents identify pain and distress in non-verbal persons with ID, and their attitudes towards using wearable sensors to identify pain and distress in daily life situations. METHODS: Exploratory, mixed method study. Caregivers (83) answered an online questionnaire, and professional caregivers (18) and parents (7) were interviewed. RESULTS: Professional caregivers and parents recognise pain and distress from observations and behavioural signs that are often equivocal. They experience that this is inadequate to reliably detect pain and distress in non-verbal persons with ID. Professional caregivers and parents’ express frustration and fear that painful conditions may remain untreated. They are positive towards using wearable sensors on condition that sensors do not infringe on user autonomy and privacy. CONCLUSIONS: There is a need for sensors and methods that can objectively identify pain and distress and ensure adequate treatment, that may improve quality of life of non-verbal persons with ID.
CHANGES IN MARKERS OF NEURO-IMMUNE DISINTEGRATION IN THE SUB-ACUTE PHASE OF ISCHEMIC STROKE
Authors: Stoyanov O. M. , Khramtsov D. M. , Vikarenko M. S. , Gruzevskyi O.A. 
Published: August 2023

Background. The increase in the prevalence of CVZ gives reasons to consider the problem of combating stroke as a priority area of treatment and prevention work of medical workers all over the world.
Aim: assessment of the role of changes in markers of neuroimmune disintegration in the acute phase of ischemic stroke.
Material and methods. The study was conducted on the basis of the clinical units of the Medical Institute of the Black Sea National University named after Peter Mohyla (Mykolaiv, Odesa) in 2020-2022. At the first stage, a retrospective analysis of 150 disease histories of patients who underwent II and were undergoing rehabilitation at the "Expert Health" medical center was carried out. At the second, prospective stage, 28 patients who had II in the subacute period were examined with an in-depth immunological examination. An analysis of the dynamics of leukogram indicators, CRP, procalcitonin and other markers of inflammation was carried out. At the prospective stage, the blood content of pro-inflammatory cytokines (TNF, IL1, IL2, Il6) and anti-inflammatory cytokines (IL4, IL10) was additionally determined. Statistical processing was carried out by methods of dispersion and correlation analysis using Statistica 14.0 software (TIBCO, USA).
Results. According to the retrospective analysis, the severity of changes in leukogram and CRP content correlated with the severity of II (r=0.11-0.29). With an average NIHSS score of 10.8±0.9, the content of lymphocytes in the peripheral pool averaged 17.3±0.4%, while the total content of leukocytes was 9.4±0.2 G/l. 76 (50.7%) patients had records in their medical records regarding the assessment of the CRP level, which averaged 7.7±0.9 mg/l. In 72.7% of patients, manifestations of atherosclerosis of brachiocephalic vessels were determined, including in 31.3% - signs of critical stenosis of the carotid arteries. When comparing the levels of CRP and the severity of the atherosclerotic process, a positive correlation of average strength was found (r=0.31).
It is shown that in the subacute period at the stage of rehabilitation, the leukogram normalizes, the manifestations of the systemic inflammatory response decrease. At the same time, there are signs of stress on neuroimmune regulatory mechanisms and the need to monitor inflammatory biomarkers both in the acute and subacute stages of stroke.
Conclusions. The expressiveness of changes in leukogram and CRP content correlates with the severity of II, and high levels of CRP are a predictor of an adverse clinical outcome. When comparing the levels of CRP and the severity of the atherosclerotic process, a positive correlation of average strength was found (r=0.31). With an ischemic stroke, neuroimmune regulatory mechanisms are stressed in the subacute stage of the disease. It is advisable to monitor inflammatory biomarkers both in the acute and subacute stages of stroke.
PATHOGENETICALLY DIRECTED METHOD OF PREVENTION AND TREATMENT OF AGE-MACULAR DEGENERATION
Authors: Saldan Y. R. , Panchenko Y.O. , Malachkova N.V. 
Published: August 2023

Background. Age-related macular degeneration is one of the most common causes of blindness in developed countries, especially in people over 60 years old. The incidence of AMD is projected to increase to 288 million in 2040 compared to 196 million in 2020. Cardiovascular factors, smoking, alcohol consumption, overweight, genetic factors, and metabolic disorders are risk factors for the development of AMD. There are disorders of lipid metabolism, as well as hyperreactivity of platelet purine receptors may be associated with the progression of AMD. The AREDS2 formula is currently used to treat AMD. New therapeutic strategies aimed to correct metabolic disorders are needed to decrease the development of the late stages of AMD.
Aim: to investigate the effectiveness of improving pathogenetically directed method of prevention and treatment of age-related macular degeneration.
Materials and methods. We observed 40 patients (80 eyes), aged 50-85 years, with AMD of category 3 (intermediate AMD), who were divided into 2 groups. The main group included 20 patients (40 eyes), 14 women and 6 men, who have prescribed a complex drug according to the standard AREDS2 scheme, as well as fenofibrate (200 mg) and clopidogrel bisulfate (75 mg). The control group included 20 patients (40 eyes), 13 women and 7 men. These patients received AREDS2 standard treatment. Progression was evaluated according to the results of OCT of the macular area according to the AREDS classification and control of corrected visual acuity (CVA). The observation period was 2 years.
Results. No signs of progression were noted in patients of both observation groups within 6 months from the start of the prescribed therapy. In the patients of the control group, the progression of the disease was recorded after 1 year of observation according to both defined criteria. Changes in OCT were observed in 7,5% of patients in the control group, and a decrease in CVA- in 5%. In the patients of the main group who used the extended therapeutic regimen, after 1 year of follow-up, progression according to OCT signs was noted in 2,5% of cases, but there was no worsening of CVA. After 2 years of observation, signs of progression according to OST were recorded in the main group by 50% less than in the control group. According to CVA, disease progression was detected in 15% of the main group and 30% of the control group.
Conclusions. This study complemented already existing therapeutic strategies for the preventive treatment of AMD.
THE WORK’S FEATURES OF MAXILLO-FACIAL SURGEONS OF KYIV AND REGION DURING THE MARTIAL LAW
Authors: Palyvoda R. , Kaniura O. , Kopchak A. 
Published: August 2023

Background. Maxillofacial surgery, which took place in Ukraine as a separate legally recognized specialty, daily acquires its relevance. Treatment of inflammatory, oncological diseases, congenital malformations, defects and deformities of the face touches the person's face, which has not only medical and aesthetic, but also social significance in society. The question arises of the readiness of the personnel reserve for such a load and modern challenges.
Aim: to analyze the peculiarities of the work of maxillofacial surgeons in Kyiv and the Kyiv region during wartime, and to identify the main problems they face in their work in connection with the existing realities and to determine ways to overcome them based on the data of an anonymous questionnaire.We have developed a questionnaire on the GoogleForm platform, concerning training and advanced training of specialists, theoretical and practical aspects of the treatment of gunshot and mine-explosive trauma, as well as receiving volunteer assistance to clinical hospitals. The study involved 39 doctors of the maxillofacial profile У дослідженні прийняли участь 39 maxillo-facial surgeons and trainee from Kyiv city and Kyiv region.
Materials and methods. It was determined that doctors watched webinars (69,2%) or read specialized literature on the treatment of gunshot trauma (56,4%). for up-to-date professional information. Most (23.1%) of respondents experience a lack of qualifications when performing secondary reconstructive interventions and rehabilitation of patients with mine-explosive/gunshot. At the same time, 61.5% of doctors conducted online consultations with foreign colleagues, 48.7% - ensured the visit of foreign colleagues to their department.
Conclusion. Definitely important point is the preparation of qualified human resources in the field of maxillo-facial surgery, a special condition for development is the communication of domestic specialists with international professional community.
RETROSPECTIVE ANALYSIS OF MEDICAL CHARTS OF PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME
Authors: Savytskyi V. I. 
Published: August 2023

Background. Antiphospholipid attracts the attention of clinicians in various fields of medicine. This pathology is characterized by a triad of clinical and laboratory signs: recurrent venous or arterial thrombosis with localization in any part of the bloodstream, obstetric pathology in the form of primary premature pregnancy and intrauterine death of the fetus with hematological disorders (thrombocytopenia, hemolytic anemia).
Aim: to conduct a retrospective analysis of medical records of patients with antiphospholipid syndrome.
Materials and methods. A retrospective analysis of outpatient/inpatient medical records of 54 patients with the main diagnosis: antiphospholipid syndrome between 2016 and 2021, who were examined and treated in the rheumatology department of the Multidisciplinary Medical Center of Odesa National Medical University, was conducted. The diagnosis of antiphospholipid syndrome was established according to the recommendations of EULAR (2019), Order of the Ministry of Health of Ukraine dated October 8, 2007 No. 626 "Clinical protocol for providing medical care to patients with Antiphospholipid Syndrome" and Order of the Ministry of Health of Ukraine No. 22 dated January 20, 2015. "Clinical protocol for providing medical care to patients with immune diseases."
Results. In the general group of patients, the duration of this pathology at the time of the study ranged from 1 to 10 years. It was established that the number of appeals in connection with exacerbation of antiphospholipid syndrome depended on age and had probable differences. It was also noted that the total number of concomitant pathologies was correlated with the number of appeals regarding exacerbation of antiphospholipid syndrome. It was revealed that arthralgia and polyarthritis were most often detected in male patients aged 20-44 against the background of antiphospholipid syndrome, and skin manifestations in men aged 45-59. In women of the age group of 20-44 years, on the background of the diagnosed antiphospholipid syndrome, skin manifestations in the form of reticular liver, arthralgia and polyarthritis, as well as cardiovascular disorders, were most often noted. In women aged 45-59, arthralgia and polyarthritis and disorders of the cardiovascular system.
Using the method of collecting anamnestic data and the results of clinical laboratory examination, in accordance with current medical care protocols and diagnostic criteria for antiphospholipid syndrome, a retrospective analysis confirms the fact that antiphospholipid syndrome occurs 5 times more often in women than in men.
KARAKTERISTIK DAN ATRIBUT PRODUK TERHADAP KEPUTUSAN PEMBELIAN JAMU GENDONG DI DESA KIRINGAN, JETIS, BANTUL, YOGYAKARTA
Authors: Sumarlin Beti Rias , Al Arifa Nur Saudah 
Published: August 2023

Abstrak Penelitian ini bertujuan untuk mengetahui karakteristik dan atribut yang menjadi keputusan pembelian jamu gendong di Desa Kiringan. Jumlah responden sebanyak 100 orang yang dipilih secara acak. Metode analisis dalam penelitian ini menggunakan analisis deskriptif dan analisis fishbein. Hasil penelitian menunjukan bahwa konsumen jamu gendong di dominasi berjenis kelamin perempuan, rata-rata usia 21-30 tahun, berstatus menikah, pendidikan terakhir SMA, dan memiliki pendapatan perbulan < Rp.1.500.000,00. Atribut yang menjadi keputusan pembelian jamu gendong ada 11 atribut yaitu meliputi rasa, khasiat, komposisi, merek, kemasan, harga, keamanan, kemudahan dan ketersediaan. Atribut yang menjadi pertimbangan keputusan pembelian yaitu atribut khasiat, atribut rasa, dan atribut keamanan. Dengan total skor khasiat 8,05, rasa 6,57, keamanan 5,76. Hal ini menunjukkan bahwa konsumen sebelum membeli memperhatikan manfaat yang ada pada produk dan rasa yang menjadi pertimbangan pembelian ulang. Kata kunci : Karakteristik, Atribut, Jamu, Keputusan Pembelian
Influence of Content Marketing and Innovation Speed Toward Repurchase Intention Fashion MSME On Instagram (Case Study of Erigo Store)
Authors: Zivi Putri Mayang , Hamid Fortuna Zain , Mustofa Anwar 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh secara parsial dan simultan Konten Pemasaran dan Kecepatan Inovasi terhadap Niat Membeli Kembali UMKM fashion di Instagram Erigo Store. Selain itu, diharapkan penelitian ini menjadi bahan pertimbangan bagi perusahaan atau pelaku UMKM fashion sebagai bahan pertimbangan untuk meningkatkan Niat Membeli Kembali. Metode penelitian dalam penelitian ini termasuk penelitian asosiatif kausal dengan pendekatan kuantitatif, dengan perhitungan sampel menggunakan rumus Slovin. Sehingga sampel sebanyak seratus responden dengan motode pengambilan sampel menggunakan purposive sampling. Teknik pengumpulan data menggunakan kuesioner dan studi pustaka, serta pengujian instrument menggunakan uji validitas dan reliabilitas. Metode analisis data menggunakan analisis regresi linier berganda, uji T, uji F, dan uji koefisien determinasi R2. Model persamaan regresi Y = 10,806 + 0,342X1 + 0,447X2 + e sudah layak untuk digunakan. Berdasarkan hasil korelasi secara parsial variabel konten pemasaran (X1) memberikan pengaruh terhadap niat membeli kembali (Y) sebesar 50,69% sedangkan variabel kecepatan inovasi (X2) memberikan pengaruh terhadap niat membeli kembali (Y) sebesar 47,74%. Berdasarkan hasil koefisien determinasi R2 sebesar 53,1% niat membeli kembali dipengaruhi oleh konten pemasaran dan kecepatan inovasi, sedangkan sisanya sebesar 46,9% dipengaruhi oleh variabel lainnya yang tidak dibahas pada penelitian ini seperti viral marketing, celebrity endorser, online customer review, dan lain sebagainya. Hasil pada penelitian ini menunjukkan bahwa terdapat pengaruh konten pemasaran dan kecepatan inovasi terhadap niat membeli kembali secara simultan (Uji F), dan pengaruh konten pemasaran dan kecepatan inovasi terhadap niat membeli kembali secara parsial (Uji T) berdasarkan uji hipotesis.

Keywords: Konten Pemasaran, Kecepatan Inovasi, Niat Membeli Kembali
Proximate and Some Micronutrients (Zn, Se, Fe and I) Assessed in Goat Milk, and Cattle Milk in Sokoto, Nigeria
Authors: Salah Nura Maiakwai , Daji Atiku Yari Dogon , Umar Rilwanu , Umar AI , Sarkingobir Yusuf 
Published: August 2023

Background: Malnutrition, poverty, and information scarcity are some of the major issues affecting people in West African region. Thus, it is imperative to divulge nutritional information from a cheap and accessible food (the milk) in the region.
Objective: This study aimed at performing a proximate and Zn, Se, Fe and I micronutrients determination in goat and cattle milk in Sokoto, Nigeria.
Method: The concentrations of zinc, selenium, iron, iodine present in goat and cattle in Sokoto, Nigeria were determined using standard methods and materials of analytical grade.
Results: The result reveals (< 0.05) Zn, Se, Fe, and I in goat as follows: 9.10 ± 0.05 ppm, 2.32 ± 0.004 ppm, 10.5 ± 0.05 ppm and 7.8 ± 0.01 ppm. In cattle, the concentrations for Zn, Se, and Fe are: 5.12 ± 1.05 ppm, 1.13 ± 0.005 ppm, 9.5 ± 0.02 ppm, and 5.9 ± 0.02 ppm. The proximate values of moisture content, ash content, protein, and fat in milk collected from goat are as follows respectively: 90.21%, 0.56 %, 3.23%, and 2.44%. The proximate values in cattle milk are: 70.11%, 0.50%, 2.11%, 2.11% and 2.21% for water content, ash content, protein content, and fat content respectively.
Conclusions: Thus, the goat milk contains higher proximate contents (such as fat, water, carbohydrate, and ash), Zn, Fe, and Se than the cow milk. It is imperative for the public to properly utilize milk for its nutritious benefits.
Literature review: Vitamin D Levels and Perinatal Depression Association
Authors: Dyaningratri Azzahra Pingkan , Sawitri Brihastami 
Published: August 2023

Background: Vitamin D levels have been linked to psychological symptoms such as anxiety, depression, and impaired cognitive performance. It is found that lower vitamin D levels in early pregnancy are associated with depressive symptoms in perinatal.This study examines the association between vitamin D levels and perinatal depression. This article based on literature source from Pubmed/MEDLINE and Science Direct with keywords: vitamin D levels including 25(OH)D levels or vitamin D deficiency, prenatal, antenatal, and postpartum depression. The discussion of this study will assist readers and health professionals analyze how vitamin D levels in the body affect the incidence of antepartum depression.
Results: these are five filtered literature, the journal discusses the relationship between vitamin D levels and antepartum depression. This literature review shows that pregnant women with less than 20 ng/mL vitamin D levels are 3.3 times more at risk than pregnant women with more than 20 ng/mL. Vitamin D plays a role in the process of increasing serotonin synthesis and increasing anti-inflammatory so that it can suppress the increase in pro-inflammatory cytokines that play a role in the incidence of depression.
Conclusion: There is a correlation between vitamin D levels and the occurrence of depression during the perinatal period. It can be suggested that pregnant women check their vitamin D levels regularly.
LEFT VENTRICULAR GEOMETRY AMONG CHRONIC KIDNEY DISEASE PATIENTS: THE ROLE OF ANEMIA
Authors: AJIBARE ADEOLA , Oladimeji Oluwaseye , ODEYEMI Ayoola , Iyayi Abisola , Oladimeji Alaba , Ojo Olufemi , Adebola Alaba , Awobusuyi Jacob , Adekoya Adebowale 
Published: August 2023

BACKGROUND: Anaemia and abnormal left ventricular (LV) geometric pattern are common findings in Chronic Kidney disease (CKD) patients.
OBJECTIVES: To assess LV geometric pattern and its relationship with anaemia among CKD patients.
METHODS: A cross sectional study of 163 subjects (102 and 61 CKD subjects with and without anaemia respectively). Echocardiography determined the LV geometric pattern while packed cell volume (PCV) levels determined anaemia.
RESULTS: The mean age of subjects with and without anaemia was 54.04 ± 14.47 and 54.92 ± 15.67 years respectively (p = 0.717) while the prevalence of LVH among the two groups was 68.8% and 57.9% respectively (p = 0.174). The most frequent LV geometry in both groups was concentric LVH (53.8% and 43.9% respectively). Prevalence of LV systolic dysfunction was 45%, higher among anaemic subjects (58(61.7%) vs 10(17.5%)) p < 0.001. There was a strong negative correlation between PCV and left ventricular mass index (r = -0.345, p = 0.001) among anaemic subjects, but weak positive correlation among patients without anaemia (r = 0.001, p = 0.993).
CONCLUSION: Anaemic CKD patients had a high prevalence of abnormal LV geometry with significant contribution from anaemia. Early management of anaemia may thus improve cardiovascular outcomes.
Peningkatan Pengetahuan dan Deteksi Dini Anak Stunting pada ibu di desa Mekarsari
Authors: Sukardin Sukardin , Nasirin Chairun , Sumartyawati Ni Made 
Published: August 2023

Stunting merupakan kondisi gagal tumbuh pada anak balita akibat kekurangan gizi kronis terutama pada 1.000 Hari Pertama Kehidupan (HPK). Anak yang menderita stunting akan lebih rentan terhadap penyakit dan ketika dewasa berisiko untuk mengidap penyakit degeneratif. Dampak stunting tidak hanya pada segi kesehatan tetapi juga mempengaruhi tingkat kecerdasan anak. Deteksi dini stunting perlu dilakukan untuk menentukan tindakan selanjutnya. Kegiatan ini bertujuan untuk meningkatkan pengetahuan dan pemahaman ibu tentang deteksi dini stunting.
Metode yang dilakukan adalah melalui Pendidikan Kesehatan dan diskusi dengan bantuan media leaflet dan LCD proyektor.
Selama proses pendidikan kesehatan peserta sangat aktif dalam mengikuti kegiatan ini. Berdasarkan kuesioner yang diberikan kepada peserta sebelum dan sesudah penyuluhan, pemahaman peserta tentang deteksi dini stunting mengalami rerata peningkatan dari sebagian besar berpengetahuan cukup 65% menjadi berpengetahuan baik sebesar 87 %. Pendidikan kesehatan penting dilakukan secara terus menerus dengan metode yang tepat agar masyarakat dapat mengetahui secara dini status kesehatan anak.
Pendidikan Kesehatan Pada Orangtua Dan Guru Terhadap Penanganan Anak Tantrum TKA-TPA Wilayah Lenteng Agung
Authors: Rokhmiati Eka , Ghanesia Hari 
Published: August 2023

Tantrum pada anak merupakan cara anak mengekspresikan perasaannya. Hal ini dikarenakan anak belum dapat mengkomunikasikan dengan baik. Tantrum seringkali terjadi pada anak usia toddler hingga prasekolah, yaitu pada usia 3-6 tahun. Pengabdian masyarakat diberikan pada orangtua dan guru dengan melakukan Pendidikan kesehatan cara penanganan anak tantrum. Kusioner merupakan alat evaluasi terhadap perubahan pengetahuan setelah dilakukan pendidikan kesehatan pada orangtua dan guru. Menunjukan 43% terdapat peningkatan pengetahuan setelah dilakukan pendidikan kesehatan. Ada peningkatan Pengetahuan orangtua dan guru mengenai cara menangani anak tantrum.
Sayang Ibu dan Bayi dengan Birthing Planning melalui Teknik Hypnobirthing
Authors: Sumanti Nurwita Trisna 
Published: August 2023

Webinar pengabdian masyarakat ini bertema sayang ibu dan bayi dengan birthing planning melalui teknik hypnobirthing berbasis evidace based dengan judul Fundamental Hypnobirthing. Pengetahuan hypnobirthing untuk tenaga kesehatan khususnya sangat penting karena Animo masyarakat terhadap metode hypnobirthing saat ini begitu tinggi. Terselenggaranya webinar ini sesuai sasaran yaitu sebanyak 2.700 peserta meliputi tenaga kesehatan khususnya bidan dan perawat 66,37%, dosen 3,26%, mahasiswa 27,82%, tenaga akademisi 2,22%, ibu hamil dan masyarakat umum 0,33% dapat mewakili ilmu hypnobirthing yang berkembang dimasyarakat dan dapat di aplikasikan secara mandiri maupun berkelompok. Metode yang dilakukan adalah dengan teknik ceramah, diskusi dan tanya jawab secara online melalui zoom dan youtobe. Setelah mengikuti webinar ini peserta mendapatkan update ilmu yang dapat dipalikasikan, e-materi, e-sertifikat. Masyarakat saat ini mencari praktisi hypnobirthing dengan harapan untuk membantu mereka mengurangi rasa takut saat kehamilan sampai menjelang persalinan dan saat melahirkan nanti, karena hypnobirthing memang telah terbukti mampu menghadirkan rasa nyaman, tenang dan damai.