bluuebunny/crossref_metadata_2025_split huggingface dataset:
Los impuestos (ISR) y su impacto en la economía de los trabajadores
Authors: Chávez Chávez José Luis 
Published: January 2025

La presente investigación se centra en el marco general y el impacto económico que tiene los impuestos, en caso particular lo relativo a el Impuesto Sobre la Renta, (ISR) respecto de los trabajadores que reciben una remuneración monetaria, esto por parte de su patrón por el concepto de sueldo, En términos generales la carga fiscal por concepto de retenciones que se les realizan por concepto de Impuesto Sobre la Renta; El impacto tanto para los trabajadores como para el gobiernio es significativo, debido a que; En el primero (trabajador) le será una carga impositiva de consideración, mientras que para el segundo (Gobierno) le será un ingreso considerable de conformidad con la respectiva Ley de Ingresos de la Federación para el ejercicio fiscal 2024, esto debido a que dicho impuesto tiene la condición de ser un impuesto de carácter federal. Por otro lado gracias a las altas y variadas retenciones que suelen existir a los sueldos y remuneraciones de previsión Social. Sumado a esto tenemos que una gran mayoria de trabajadores y patrones se ocultan en la informalidad, situación que bulnera tanto al estado por no percibir impuestos, y por otro lado al resto de los trabajadores y patrones que se encuentran regulados por sus actos cononómicos en el país; es de gran trascendencia que el Gobierno Federa, tienda esos puentes que hagan que las cargas impositiivas por esté concepto (Remuneración por la prestación de un servicio subordinado) sean bajas y faciles de enterar a la autoridad fiscal, lo anterior ayudaría a que se regularán muchos trabajadores y patrones que por años han permanecido en la informalidad, el depender en el pago de impuestos de una plataforma electrónica que en la mayoria de los casos no funciona, situación que complica el cumplir con los preceptos constituciones de forma facil y a tiempo, evitando con esto actualización de contribuciones y recargos a los patrones obligados a efectuar el respectivo impuesto, aunado a que si el trabajador está obligado a elaborar por su cuenta la respectiva declaración anual, esta carga tributaria financiera le será trasladada directamente al trabajador.
Efficacy and safety of acupuncture monotherapy or combined with pelvic floor muscle training for female stress urinary incontinence: a systematic review and meta-analysis
Authors: Jiang Tong , Dong Zhi-Yu , Shi Ying , Zhou Yang-Qing , Zhang Hong-Bin , Gong Yi 
Published: January 2025

BackgroundStress urinary incontinence (SUI) is involuntary urine leakage during effort. Pelvic floor muscle training (PFMT) is a common physical therapy for SUI, but has low adherence and its long—term effectiveness is uncertain. Drug therapy has side-effect problems and surgery has risks. Acupuncture’s role in improving SUI is also unclear based on previous studies.ObjectivesThis systematic review and meta-analysis evaluated the efficacy and safety of acupuncture individually or combined with PFMT in improving symptoms and women’s health-related quality of life of SUI.DesignA systematic review and meta-analysis were conducted.PatientsWomen with stress urinary incontinence were treated with electroacupuncture (EA) individually or acupuncture combined with PFMT.ResultsIn the analysis comparing urinary leakage 1 h and the ICIQ-SF score, electroacupuncture (EA) intervention was significantly associated with improvements in both urine leakage (MD = 4.69, 95% CI 2.83 to 6.55, I2 = 62%) and ICIQ-SF (MD = 2.61, 95% CI 1.64 to 3.58, I2 = 65%). The results were robust for the sensitivity analyses. EA was not associated with an increased incidence of adverse events compared to placebo EA (RR = 1.08, 95% CI 0.50 to 2.35, I2 = 0%). When comparing the group receiving pelvic floor muscle training (PFMT) combined with acupuncture to the PFMT only group, the combination therapy was found to improve urine leakage 1 h (MD = 1.91, 95% CI 0.96 to 2.86, I2 = 80%) and improve ICIQ-SF (MD = 2.63, 95% CI 1.60 to 3.65, I2 = 75%) in patients with SUI, despite significant heterogeneity observed. Subgroup analyses based on urine leakage 1 h revealed that subjects with mild stress urinary incontinence showed improvements (MD = 1.46, 95% CI 0.82 to 2.10, I2 = 58%), as did those with moderate stress urinary incontinence (MD = 4.9, 95% CI 1.72 to 8.08, I2 = 77%). There were significant differences between these subgroups (I2 = 77%, p = 0.04). In the subgroup analysis of intervention types, manual acupuncture showed no significant effect when combined (MD = 1.11, 95% CI -0.61 to 2.83, I2 = 86%).ConclusionThe findings from this meta-analysis indicate that EA is more effective at improving the clinical symptoms and quality of life in patients with SUI compared to placebo EA, and it does not increase the risk of adverse events. Moreover, the therapeutic effect of SUI treatment with EA combined with pelvic floor muscle training (PFMT) elicits a more positive response than PFMT alone. This suggests that EA, either as a standalone therapy or as an adjunct to PFMT, can offer beneficial outcomes for individuals with stress urinary incontinence, expanding the range of clinical treatment options available.Systematic Review RegistrationThe meta-analysis was registered in PROSPERO (CRD42022381409).
Getah virus triggers ROS-mediated autophagy in mouse Leydig cells
Authors: Li Fengqin , Deng Lishuang , Xu Tong , Xu Lei , Xu Zhiwen , Lai Siyuan , Ai Yanru , Wang Yanqun , Yan Guangwen , Zhu Ling 
Published: January 2025

IntroductionGetah virus (GETV) is a zoonotic virus transmitted via a mosquito-vertebrate cycle. While previous studies have explored the epidemiology and pathogenicity of GETV in various species, its molecular mechanisms remain largely unexplored.MethodsThis study investigated the impact of GETV infection and associated molecular mechanisms on reactive oxygen species (ROS) and autophagy levels in mouse Leydig cells both in vivo and in vitro. The male mice and TM3 cells were treatment with N-acetylcysteine (NAC) to reduce cellular ROS levels. Rapamycin (Rapa) and 3-Methyladenine (3- MA) were used to change autophagy in both infected and uninfected TM3 cells.Results and DiscussionThe findings revealed that GETV infection in mouse testes speciffcally targeted Leydig cells and induced oxidative stress while enhancing autophagy in testicular tissue. Using TM3 cells as an in vitro model, the study confirmed GETV replication in this cell line, triggering increased ROS and autophagy levels. Treatment with N-acetylcysteine (NAC) to reduce cellular ROS levels markedly reduced autophagy in testicular tissue and TM3 cells infected with GETV. Interestingly, the use of rapamycin (Rapa) and 3-Methyladenine (3- MA) led to autophagy change in both infected and uninfected TM3 cells, with no signiffcant alterations in cellular ROS levels. These results indicate that GETV infection elevates ROS levels, subsequently inducing autophagy in mouse Leydig cells. We also found that autophagy plays an important role in GETV replication. When autophagy levels were reduced using NAC and 3-MA, a corresponding decrease in TCID50 was observed. Conversely, upregulation of autophagy using Rapa resulted in an increase in TCID50 of GETV. Therefore, we speculate that GETV may exploit the autophagy pathway to facilitate its replication. These ffndings illuminate the interplay between GETV and host cells, providing valuable insights for therapeutic strategies targeting autophagy in GETV infections.
CSNK1E is involved in TGF-β1 induced epithelial mesenchymal transformationas and related to melanoma immune heterogeneity
Authors: Hong Wangbing , Wang Xin , Huang Xinyu , Chen Pengfei , Liu Yifan , Zheng Ziying , You Xin , Chen Yinghua , Xie Zengxin , Zhan Gongnan , Huang Heping 
Published: January 2025

IntroductionMelanoma (MM), the deadliest form of skin cancer, originates from melanocytes. Despite advances in immunotherapy that have somewhat improved the prognosis for MM patients, high levels of resistance to treatment continue to result in poor clinical outcomes. Identifying novel biomarkers and therapeutic targets is critical for improving the prognosis and treatment of MM.MethodsIn this study, we analyzed the expression patterns of WNT signaling pathway genes in MM and explored their potential mechanisms. Using Cox regression analysis, we identified 19 prognostic-related genes. Consistency clustering was performed to evaluate the potential of these genes as classifiers for prognosis. The Least Absolute Shrinkage and Selection Operator (LASSO) algorithm was then applied to refine the gene set and construct a 13-gene prognostic model. We validated the model at multiple time points to assess its predictive performance. Additionally, correlation analyses were performed to investigate the relationships between key genes and processes, including epithelial-to-mesenchymal transition (EMT) and immune responses.ResultsWe identified that CSNK1E and RAC3 were significantly positively correlated with the EMT process, with CSNK1E showing a similar expression trend to EMT-related genes. Both genes were also negatively correlated with multiple immune cell types and immune checkpoint genes. The 13-gene prognostic model demonstrated excellent predictive performance in MM prognosis. Pan-cancer analysis further revealed heterogeneous expression patterns and prognostic potential of CSNK1E across various cancers. Wet experiments confirmed that CSNK1E promotes MM cell proliferation, invasion, and migration, and enhances malignant progression through the TGF-β signaling pathway.DiscussionOur findings suggest that CSNK1E plays a crucial role in MM progression and could serve as a potential therapeutic target. The WNT and TGF-β pathways may work synergistically in regulating the EMT process in MM, highlighting their potential as novel therapeutic targets. These insights may contribute to the development of more effective treatments for MM, particularly for overcoming resistance to current therapies.
Prospects for the Use of Quasi-Mersen Numbers in the Design of Parallel-Serial Processors
Authors: Kadyrzhan Aruzhan , Kadyrzhan Kaisarali , Bakirov Akhat , Suleimenov Ibragim 
Published: January 2025

It is shown that a serial-parallel processor, comparable in bit capacity to a 16-bit binary processor, can be implemented based on an algorithm built on the residue number system, a distinctive feature of which is the use of the first four quasi-Mersenne numbers, i.e., prime numbers representable as pk=2k+1, k=1,2,3,4. Such a set of prime numbers satisfies the criterion 2p1p2p3p4+1=P, where P is also a prime number. Fulfillment of this criterion ensures the possibility of convenient use of the considered RNS for calculating partial convolutions developed for the convenience of using convolutional neural networks. It is shown that the processor of the proposed type can be based on the use of a set of adders modulo a quasi-Mersenne number, each of which operates independently. A circuit of a modulo 2k+1 adder is proposed, which can be called a trigger circuit, since its peculiarity is the existence (at certain values of the summed quantities) of two stable states. The advantage of such a circuit, compared to known analogs, is the simplicity of the design. Possibilities for further development of the proposed approach related to the use of the digital logarithm operation, which allows reducing the operations of multiplication modulo 2k+1 to addition operations, are discussed.
An Overview of the CMS High Granularity Calorimeter
Authors: Akgün Bora 
Published: January 2025

Calorimetry at the High Luminosity LHC (HL-LHC) faces many challenges, particularly in the forward direction, such as radiation tolerance and large in-time event pileup. To meet these challenges, the CMS Collaboration is preparing to replace its current endcap calorimeters from the HL-LHC era with a high-granularity calorimeter (HGCAL), featuring an unprecedented transverse and longitudinal segmentation, for both the electromagnetic and hadronic compartments, with 5D information (space–time–energy) read out. The proposed design uses silicon sensors for the electromagnetic section (with fluences above 1016 neq/cm2) and high-irradiation regions (with fluences above 1014 neq/cm2) of the hadronic section, while in the low-irradiation regions of the hadronic section, plastic scintillator tiles equipped with on-tile silicon photomultipliers (SiPMs) are used. Full HGCAL will have approximately 6 million silicon sensor channels and about 280 thousand channels of scintillator tiles. This will allow for particle-flow-type calorimetry, where the fine structure of showers can be measured and used to enhance particle identification, energy resolution and pileup rejection. In this overview we present the ideas behind HGCAL, the current status of the project, results of the beam tests and the challenges that lie ahead.
Partisipasi Masyarakat dalam Pengembangan Ekowisata di Kelurahan Suka Marga Kecamatan Suoh Kabupaten Lampung Barat
Authors: Abiyad Shamil Nafsun , Rifqi Asy'ari Rifqi Asy'ari , Mustofa Asep Nurul Ajiid , Putra Rifki Rahmanda 
Published: January 2025

Kelurahan Suka Marga ini memiliki kekayaan dan keindahan gejala alam berupa tiga danau terpisahan antara lain Danau Asam, Danau Minyak, dan Danau Lebar. Keragam kekayaan alam di Kelurahan Suka Marga ini dapat menjadi modal awal bagi perkembangan kehidupan sosial masyarakat setempat. Potensi gejala alam yang ada memiliki dapat mendorong pembangunan daerah, juga menarik minat wisatawan dalam negeri maupun luar negeri untuk dapat berkunjung ke Kelurahan Suka Marga, Kabupaten Lampung Barat. Oleh karena itu, partisipasi masyarakat penting untuk diikutsertakan dan dilibatkan dalam mengembangkan pariwisata yang ada di Kelurahan Suka Marga. Penelitian ini menggunakan pendekatan deduktif, dengan menggunakan metode analisis kualitatif dan dengan mengidentifikasi 8 variabel Tangga Partisipasi Arnstein dan keikutsertaan masyarakat dalam pengembangan ekowisata di Kelurahan Suka Marga, Kabupaten Lampung Barat. Hasil penelitian menunjukan bahwa partisipasi masyarakat tergolong sedang yaitu berada pada tangga kelima atau placation, artinya pemerintah dan masyarakat sudah tergolong aktif dalam proses perencanaan. Masyarakat juga sudah menunjukkan keterlibatan dalam diskusi dengan pemerintah mengenai usulan, kritik maupun saran mengenai pembangunan ekowisata. Proses pelaksanaan, perencanaan, dan pembangunan tetap dilakukan sesuai dengan ketetapan pemerintah. Hambatan dalam pembangunan yaitu masih terdapatnya faktor – faktor lain seperti sumber daya manusia yang belum sepenuhnya dapat melakukan perencanaan, perancangan, dan pengelolaan secara mandiri. Hasil penelitian ini dapat menjadi titik awal bagi masyarakat untuk berkembang dan mengetahui potensi serta mampu mendapatkan kepercayaan pemerintah untuk memberikan kewenangan penuh dalam merencanakan, merancang dan mengelola ekowisata yang ada di Kelurahan Suka Marga dan bentuk perhatian pemerintah dapat melakukan pelatihan kepada masyarakat agar pengembangan ekowisata dapat menjadi berkembang.
La série cristallophyllienne renversée du Plateau d’Aigurande
Authors: Delorme Johannès , Emberger André 
Published: January 2025

Les schistes cristallins du Plateau d’Aigurande, traversés par la vallée de la Creuse, constituent une série métamorphique comprenant les zones des micaschistes inférieurs, des gneiss supérieurs, des gneiss inférieurs et des migmatites. Dans cette région, le front des migmatites se trouve dans la zone des gneiss inférieurs. La série cristallophyllienne est disposée en un anticlinal dont les micaschistes inférieurs forment le noyau.
Sur lé versant Sud, on trouve, en s’éloignant de l’axe anticlinal, la succession des gneiss supérieurs, des gneiss inférieurs et des embréchites. Dans le flanc Nord, il existe une superposition analogue, mais les gneiss inférieurs ont été supprimés le long de la ligne de contact normal de Gargilesse. Les migmatites ont été poussées vers le Sud, directement au-dessus des gneiss supérieurs. La série cristallophyllienne du Plateau d'Aigurande est donc entièrement renversée. Elle représente vraisemblablement le flanc inverse d’un vaste pli couché, poussé du Nord au Sud, dans lequel la structure anticlinale résulterait soit d’une disposition en tète plongeante, soit de plissements ultérieurs. Ces formations sont, en outre, traversées par des massifs granitiques dont la mise en place est postérieure au renversement de la série. Vers le Sud. les schistes cristallins du Plateau d’Aigurande sont séparés de la chaîne granulitique de la Marche par la dislocation de Boussac.
Flore autunienne des « quartzites de Meillers » (Permien inférieur du bassin de Bourbonl’Archambault, Allier, Massif central, France) / Autunian flora from the « quartzite of Meillers » (Lower Permian basin of Bourbon-l’Archambault, Central France)
Authors: Legrand Philippe , Debriette Pierre 
Published: January 2025

Les «quartzites de Meillers» sont un dépôt siliceux d’origine hydrothermale, situé au niveau des grès autuniens (Permien inférieur) du bassin de Bourbon-l’Archambault (bordure Nord du Massif Central, France). La silice s’est déposée au niveau de sources chaudes ou de geysers et ce dépôt a été daté à 300 ± 21 Ma. La calcédonite blanche terminale est finement rubanée et montre des festons et des structures en chou-fleur qui suggèrent une origine organique ; cette calcédonite a été interprétée comme un dépôt stromatolithique dans un environnement de sources chaudes. La flore algaire associée à ces stromatolithes comprend les morpho-espèces Baltzerella stephaniense Freytet, Hanskerpella pustulata Freytet, Ponsinella multifrons Freytet et Sarfatigirella intricata Freytet.
La présence d’une macroflore autunienne (Permien inférieur) est pour la première fois décrite et figurée. Celle-ci comprend principalement : un eusigillaire (Sigillaria Brongniart f. Syringodendron [Pteridophyta, Lycopodiophytina, Lepidophytales]), des bois silicifiés de Psaronius Cotta (Pteridophyta, Filicophytina, Filicales), un bois silicifié de Calamites Suckow (Pteridophyta, Sphenophytina, Calamitales), des épis fructifères de Calamitales ou de Sphenophyllales (Pteridophyta, Sphenophytina), et des Dadoxylon Endlicher (bois silicifiés de Cordaites [Prespermatophyta, Cordaitophytina, Cordaitales] ou de Coniférophytes [Spermatophyta, Gymnospermophytina, Coniferopsida] ou de Ginkgophytes [Prespermatophyta, Ginkgophytina, Ginkgoales]).
Le dépôt stromatolithique terminal du quartzite de Meillers est comparé avec les niveaux stromatolithiques silicifiés de Souvigny (bassin permien de Bourbon-l’Archambault) ; ces deux niveaux stromatolithiques sont probablement contemporains et silicifiés par le même événement hydrothermal.
20 ans d’herborisations en Auvergne / 20 years herborizations in Auvergne
Authors: Lamaison Jean-Louis 
Published: January 2025

20 years herborizations in Auvergne
Floristic prospectings were realized between 1992 and 2012 in Auvergne (Central France). During these years, about a hundred taxa have been reported by the author for the first time in the region.
A Reliability-Based Design of Africa-Birch Timber-Reinforced Concrete Beams
Authors: Aliyu Abdulrazaq Alhassan , Nyong Wilson Uwemedimo , Engbonye Sani John , Rabiu Ibrahim 
Published: January 2025

This study investigates the reliability-based design of African-Birch (AB) timber-reinforced concrete beams. This study investigated Some of the physical and engineering properties of the constituent materials for the reinforced concrete beams were tested and preparing the reinforcement in four different composition and configurations (steel-steel, Steel- AB, AB-Steel, and AB-AB) of the beams were prepared, cast and cured for varying durations (3, 7, 14, 21, and 28 days), and the concrete was tested for its flexural strength and deflection and consequently reliability analysis (in terms of flexural strength and deflection) of all the beam configurations using First Order Reliability Analysis-5 (FORM5) to assess the beam performance was carried out. The flexural strength and deflection analysis reveals Steel-AB outperforming other sections and was found to be optimal under various loading conditions. For flexure, Steel-AB achieved a safety index (β) of 1.98 and probability of failure (Pf) of 0.0238 at a span length of 10,000mm and effective depth of 400mm. Similarly, for deflection, Steel-AB demonstrated a safety index (β) of 1.786 and probability of failure (Pf) of 0.037 at a span length of 2500mm. This study demonstrates that African-birch timber is a viable and sustainable alternative to traditional steel reinforcement for structural applications, particularly for medium span and depth beam-configurations.
Importância e implicações envolvidas nos cuidados paliativos na área da emergência
Authors: Netto Pedro Castro Martins , Martins João Vitor Samuel Castro , Carvalho Letícia Batista de , Moreira Letícia Carvalho , Silva Fernando Bueno Rossi 
Published: January 2025

Os cuidados paliativos tem inúmeros desafios e inúmeros momentos é desvalorizado no setor da emergência , por exemplo com a falta de apoio emocional e assistência aos familiares.Objetiva-se garantir informação e explicação dos cuidados paliativos. Para tanto, procede-se a uma revisão narrativa com a base de dados dos artigos científicos indexados no SciELO e do Medline via PubMed. Desse modo, observa-se que , há incipiência em lidar com a dor e terminalidade de vida que muitas vezes é tratado com superficialidade conforme é tratado nas universidades e não há correspondência com a relevância, o que permite concluir que os cuidados paliativos não possuía a devida importância como disciplina nas universidades.
Hemotransfusão maciça no pré-hospitalar
Authors: Junior Heros Souza Couto , Daré Ana Carolina de Castro Bahia , Mendes Juliana Cristina de Lima , Leal Renata Teixeira , Jorge Giovana Diniz , Schichman Luísa Lage , Gonzaga Mariana Ramos , Silva Sofia Xavier 
Published: January 2025

Contexto: esta revisão integrativa analisa a eficácia da hemotransfusão maciça no ambiente pré-hospitalar, com foco em traumas graves e hemorragias. Destaca a “Golden Hour”, primeira hora após o trauma, como crucial para a sobrevivência. A hemorragia é identificada como principal causa de morte evitável, sendo a transfusão de sangue e hemoderivados uma intervenção essencial para estabilizar pacientes politraumatizados. Metodologia: baseando-se em literaturas (2004-2024), o estudo avalia práticas nacionais e internacionais, como o uso de protocolos de transfusão maciça e ferramentas diagnósticas (ex.: Índice de Choque). Resultados: nota-se redução de mortalidade e melhora hemodinâmica em pacientes que receberam transfusões pré-hospitalares. No Brasil, essa prática já ocorre em cidades como Florianópolis e Blumenau. Apesar dos avanços, os desafios incluem logística para transporte de sangue, treinamento de equipes e coordenação entre setores. Conclusão: transfusão pré-hospitalar é eficaz e segura, mas requer mais estudos e infraestrutura para otimizar sua aplicação.