bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of sarcopenia indicators and sub-optimal protein intake among elective total joint replacement patients
Authors: Coletta Giulia , Jakubowski Josephine S. , Phillips Stuart M. , Atkinson Stephanie , Papaioannou Alexandra , Pritchard Janet M. 
Published: March 2023

Sarcopenia is associated with falls, and can complicate recovery following total joint replacement (TJR) surgery. We examined (1) the prevalence of sarcopenia indicators and lower-than-recommended protein intake among TJR patients and non-TJR community participants and (2) the relationships between dietary protein intake and sarcopenia indicators. We recruited adults ≥65 years of age who were undergoing TJR, and adults from the community not undergoing TJR (controls). We assessed grip strength and appendicular lean soft-tissue mass (ALSTMBMI) using DXA, and applied the original Foundation for the National Institutes of Health Sarcopenia Project cut-points for sarcopenia indicators (grip strength <26 kg for men and <16 kg for women; ALSTM <0.789 m2 for men and <0.512 m2 for women) and less conservative cut-points (grip strength <31.83 kg for men and <19.99 kg for women; ALSTM <0.725 m2 for men and <0.591 m2 for women). Total daily and per meal protein intakes were derived from 5-day diet records. Sixty-seven participants (30 TJR, 37 controls) were enrolled. Using less conservative cut-points for sarcopenia, more control participants were weak compared with TJR participants (46% versus 23%, p = 0.055), and more TJR participants had low ALSTMBMI (40% versus 13%, p = 0.013). Approximately 70% of controls and 76% of TJR participants consumed <1.2 g protein/kg/day ( p = 0.559). Total daily dietary protein intake was positively associated with grip strength ( r = 0.44, p = 0.001) and ALSTMBMI ( r = 0.29, p = 0.03). Using less conservative cut-points, low ALSTMBMI, but not weakness, was more common in TJR patients. Both groups may benefit from a dietary intervention to increase protein intake, which may improve surgical outcomes in TJR patients.
Temporal patterns of reciprocity in communication networks
Authors: Chowdhary Sandeep , Andres Elsa , Manna Adriana , Blagojević Luka , Di Gaetano Leonardo , Iñiguez Gerardo 
Published: March 2023

AbstractHuman communication, the essence of collective social phenomena ranging from small-scale organizations to worldwide online platforms, features intense reciprocal interactions between members in order to achieve stability, cohesion, and cooperation in social networks. While high levels of reciprocity are well known in aggregated communication data, temporal patterns of reciprocal information exchange have received far less attention. Here we propose measures of reciprocity based on the time ordering of interactions and explore them in data from multiple communication channels, including calls, messaging and social media. By separating each channel into reciprocal and non-reciprocal temporal networks, we find persistent trends that point to the distinct roles of one-to-one exchange versus information broadcast. We implement several null models of communication activity, which identify memory, a higher tendency to repeat interactions with past contacts, as a key source of temporal reciprocity. When adding memory to a model of activity-driven, time-varying networks, we reproduce the levels of temporal reciprocity seen in empirical data. Our work adds to the theoretical understanding of the emergence of reciprocity in human communication systems, hinting at the mechanisms behind the formation of norms in social exchange and large-scale cooperation.
Twisted intersection colorings, invariants and double coverings of twisted links
Authors: Ito Hiroki , Kamada Seiichi 
Published: March 2023

Twisted links are a generalization of classical links and correspond to stably equivalence classes of links in thickened surfaces. In this paper, we introduce twisted intersection colorings of a diagram and construct two invariants of a twisted link using such colorings. As an application, we show that there exist infinitely many pairs of twisted links such that for each pair the two twisted links are not equivalent but their double coverings are equivalent. We also introduce a method of constructing a pair of twisted links whose double coverings are equivalent.
High-Performance Multi-RNS-Assisted Concurrent RSA Cryptosystem Architectures
Authors: Elango S. , Sampath P. , Raja Sekar S. , Philip Sajan P , Danielraj A. 
Published: March 2023

In public-key cryptography, the RSA algorithm is an inevitable part of hardware security because of the ease of implementation and security. RSA Cryptographic algorithm uses many modular arithmetic operations that decide the overall performance of the architecture. This paper proposes VLSI architecture to implement an RSA public-key cryptosystem driven by the Residue Number System (RNS). Modular exponentiation in the RSA algorithm is executed by dividing the entire process into modular squaring and multiplication operations. Based on the RNS employment in modulo-exponential operation, two RSA architectures are proposed. A Verilog HDL code is used to model the entire RSA architecture and ported in Zynq FPGA (XC7Z020CLG484-1) for Proof of Concept (PoC). The Cadence Genus Synthesizer tool characterizes a system’s performance for TSMCs standard Cell library. Partial RNS (Proposed-I)- and Fully RNS (Proposed-II)-based RSA architectures increase the operation speed by 13% and 35%, respectively, compared with the existing RSA. Even though there is an increase in parameters like area, power and PDP for a smaller key size, the improvement in area utilization and encryption/ decryption speed of RSA for a larger key size is evident from the analysis.
Sagittal trunk excursion and lumbar repositioning error between female and male patients with patellofemoral pain syndrome
Authors: Ibrahim Hassan Ibrahim Mohamed , Keblawy Maher El , Elsalam Mohammed Abd , Embaby Eman Ahmed 
Published: March 2023

Background: Patellofemoral pain syndrome (PFPS) is a challenging clinical problem affecting adults, adolescents, and physically active populations. PFPS impacts the patient’s trunk kinematics in the frontal plane. Previous studies have found gender-based biomechanical differences in patients with PFPS; however, sagittal trunk kinematics during mini-squats and lumbar proprioception in PFPS have not been studied previously.Objectives: To investigate sagittal trunk excursion (It is defined as the sagittal trunk flexion angle from the start to the end of the mini squat) during mini-squats as well as lumbar repositioning error between individuals with and without PFPS, and determine gender differences in the outcome variables.Methods: A sample of 56 participants aged 18–25 years was enrolled; 30 with PFPS (13 males, 17 females) and 26 asymptomatic controls (11 males, 15 females). The sagittal trunk excursion during mini-squats was examined by two-dimensional (2D) photographic analysis using Surgimap software. Active lumbar flexion repositioning error was assessed using an isokinetic dynamometer.Results: For sagittal trunk excursion, no significant main effect of group was observed ([Formula: see text]). On the other hand, the main effect was significant for gender ([Formula: see text]), as was the interaction effect. Compared to the control group, the PFPS group showed significantly ([Formula: see text]) lower sagittal trunk excursion in females than in males during mini-squats. For active lumbar flexion repositioning error, no evidence was found for significant main or interaction effects ([Formula: see text]).Conclusion: Females with PFPS exhibit a more erect sagittal trunk posture than males during mini-squats. Trunk posture should be considered during weight-bearing activities in PFPS, and gender-specific assessment protocols should be developed.
Impact of Fasting Blood Glucose Levels on Blood Pressure Parameters among Older Adults with Prediabetes
Authors: Roengrit Thapanee , Sri-Amad Ruchada , Huipao Nawiya , Phababpha Suphawadee , Prasertsri Piyapong 
Published: March 2023

Prediabetes mellitus (pre-DM) is defined as blood glucose levels higher than normal but lower than the threshold for diabetes mellitus (DM) diagnosis. Four-limb blood pressure (BP) differences can help identify a significant risk for cardiovascular diseases (CVDs). The current study aimed to determine the importance of BP and the ankle-brachial index (ABI) between two patient groups and the association between fasting blood glucose (FBG) levels and four-limb BP, ABI, interarm BP difference (IAD), and interleg BP difference (ILD). Moreover, the effect of cardiovascular risk factors on the development of pre-DM among older adults was evaluated. The participants were divided into the normal fasting glucose (NFG) and impaired fasting glucose (IFG) groups. Data on physical characteristics, lipid profiles, four-limb BP, ABI, IAD, ILD, and cardiovascular risk factors were assessed. The IFG group had a significantly higher systolic blood pressure (SBP) and pulse pressure than the NFG group (

p

<

0.05

). SBP was significantly positively correlated with FBG levels (

p

<

0.05

). The IFG group had a lower ABI than the NFG group (

p

<

0.05

). However, there was no significant difference in terms of IAD and ILD between the two groups. Furthermore, hypertension (HT), metabolic syndrome (MetS), and dyslipidemia were significantly correlated with a high prevalence of prediabetes (

p

<

0.05

). Individuals with prediabetes had a higher BP than those with normoglycemia. Prediabetes was correlated with HT, MetS, and dyslipidemia.
Personalized Treatment of Periodontitis in a Patient with McArdle’s Disease: The Benefits from Probiotics
Authors: Cannizzaro Salvatore , Maiorani Carolina , Scribante Andrea , Butera Andrea 
Published: March 2023

Introduction. McArdle’s disease is a severe glycogen storage disease characterized by intolerance to exercise; patients have a syndrome of muscle intolerance to stress, associated with myalgia, cramps, fatigue, and muscle weakness. Periodontal disease is a multifactorial pathology of the supporting tissues of the teeth: one of the main factors is the formation of bacterial biofilm; its control favors the prevention and the maintenance of good health of the oral cavity; and some systemic pathologies can worsen the periodontal disease and hinder its therapy. This case report concerns a woman with McArdle’s disease diagnosed with periodontal disease. Material and Methods. A 54-year-old female patient with McArdle’s disease has been diagnosed with Stage 3 generalized periodontitis, Grade B. At the baseline, the patient had 82 pockets with probing pocket depth (PPD) equal to or greater than 4 mm. The patient was instructed in the correct methods of oral hygiene and was advised toothpaste and mouthwash based on probiotics; subsequently, a debridement was performed to remove etiological factors using Dental-Biofilm Detection Topographic Technique (D-BioTECH). Results. After 60 days, the number of pockets was reduced from 82 to 14 overall with

PPD
≥
4

mm

and from 50 to 2 pockets with

PPD
≥
5

mm

. Full mouth bleeding score (FMBS) increased from 48% to 15% and full mouth plaque score (FMPS) from 73% to 15%. Conclusions. In this case, the use of a correct brushing method combined with the D-BioTECH has reduced the disease state, with the use of probiotics at home to restore and maintain a healthy oral microbiome.
HDAC3 Inhibition Promotes Antitumor Immunity by Enhancing CXCL10-Mediated Chemotaxis and Recruiting of Immune Cells
Authors: Li Lili , Hao Shumin , Gao Meiling , Liu Junxiao , Xu Xin , Huang Jianfei , Cheng Genhong , Yang Heng 
Published: March 2023

AbstractIt is generally believed that histone deacetylase (HDAC) inhibitors, which represent a new class of anticancer agents, exert their antitumor activity by directly causing cell-cycle arrest and apoptosis of tumor cells. However, in this study, we demonstrated that class I HDAC inhibitors, such as Entinostat and Panobinostat, effectively suppressed tumor growth in immunocompetent but not immunodeficient mice. Further studies with Hdac1, 2, or 3 knockout tumor cells indicated that tumor-specific inactivation of HDAC3 suppressed tumor growth by activating antitumor immunity. Specifically, we found that HDAC3 could directly bind to promotor regions and inhibit the expression of CXCL9, 10, and 11 chemokines. Hdac3-deficient tumor cells expressed high levels of these chemokines, which suppressed tumor growth in immunocompetent mice by recruiting CXCR3+ T cells into the tumor microenvironment (TME). Furthermore, the inverse correlation between HDAC3 and CXCL10 expression in hepatocellular carcinoma tumor tissues also suggested HDAC3 might be involved in antitumor immune regulation and patient survival. Thus, our studies have illustrated that HDAC3 inhibition suppresses tumor growth by enhancing immune cell infiltration into the TME. This antitumor mechanism may be helpful in guiding HDAC3 inhibitor–based treatment.
How Many People Were Killed by Windblown Dust Events in the United States?
Authors: Tong Daniel , Feng Irene , Gill Thomas E. , Schepanski Kerstin , Wang Julian 
Published: March 2023

Abstract
Windblown dust events, including dust storms and smaller blowing dust events, pose severe risks to public health and transportation safety. In the United States, the statistics of fatalities caused by dust events remains elusive. We developed a new dataset by merging dust fatality data from NOAA Storm Events Database and the Department of Transportation Fatality Analysis Reporting System (FARS). There was a total of 232 deaths from windblown dust events from 2007 to 2017. This number is much larger than that reported by the NOAA Natural Hazard Statistics, which assigns some dust fatalities to high winds and thunderstorms (∼45%) and does not include many events in FARS. Dust fatalities are most frequent over the Southwest, consistent with the spatial distribution of dust storm occurrences. Other high-risk regions include the Colorado Plateau, Columbia Plateau in Washington and Oregon, the High Plains where the disastrous “Dust Bowl” occurred, and the Corn Belt where blowing dust from croplands presents a driving hazard. All six most deadly dust wrecks (three deaths or more) involved semi trucks and five of them were caused by dust storms along Interstate 10. There exist two “hotspots” for dust fatalities: 1) the “Deadliest 10 Miles” between Phoenix and Tucson, Arizona, and 2) Lordsburg Playa in New Mexico, where active dust mitigation projects have been managed by state transportation agencies. In most years, dust events caused comparable life losses to that from other weather hazards such as hurricanes, thunderstorms, lightning, and wildfires. This work presents new evidence that dust is an underappreciated weather hazard.
Anti-CD19 CAR T-cell consolidation therapy combined with CD19+ feeding T cells and TKI for Ph+ acute lymphoblastic leukemia
Authors: Chen Li-Yun , Gong Wen-Jie , Li Ming-Hao , Zhou Hai-Xia , Xu Ming-Zhu , Qian Chong-Sheng , Kang Li-Qing , Xu Nan , Yu Zhou , Qiao Man , Zhang Tong-Tong , Zhang Ling , Tian Zheng-Long , Sun Ai-Ning , Yu Lei , Wu De-Pei , Xue Sheng-Li 
Published: March 2023

Abstract
We conducted a single-arm, open-label, single-center phase 1 study to assess the safety and efficacy of multicycle-sequential anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in combination with autologous CD19+ feeding T cells (FTCs) and tyrosine kinase inhibitor (TKI) as consolidation therapy in patients under the age of 65 years with de novo Ph-positive CD19+ B-cell acute lymphoblastic leukemia. Participants were given induction chemotherapy as well as systemic chemotherapy with TKI. Afterward, they received a single cycle of CD19 CAR T-cell infusion and another 3 cycles of CD19 CAR T-cell and CD19+ FTC infusions, followed by TKI as consolidation therapy. CD19+ FTCs were given at 3 different doses. The phase 1 results of the first 15 patients, including 2 withdrawals, are presented. The most common adverse events were cytopenia (13/13) and hypogammaglobinemia (12/13). There was no incidence of cytokine release syndrome above grade 2 or immune effector cell-associated neurotoxicity syndrome or grade 4 nonhematological toxicities. All 13 patients achieved complete remission, including 12 patients with a complete molecular response (CMR) at the data cutoff. The relapse-free survival was 84%, and the overall survival was 83% with a median follow-up of 27 months. The total number of CD19-expressing cells decreased with an increasing CMR rate. CD19 CAR T cells survived for up to 40 months, whereas CD19+ FTCs vanished in 8 patients 3 months after the last infusion. These findings could form the basis for the development of an allo-HSCT–free consolidation paradigm. This trial was registered at www.clinicaltrials.gov as #NCT03984968.
Brentuximab vedotin after autologous transplantation in pediatric patients with relapsed/refractory Hodgkin lymphoma
Authors: Forlenza Christopher J. , Rosenzweig Jaclyn , Mauguen Audrey , Buhtoiarov Ilia , Cuglievan Branko , Dave Hema , Deyell Rebecca J. , Flerlage Jamie E. , Franklin Anna K. , Krajewski Jennifer , Leger Kasey J. , Marks Lianna J. , Norris Robin E. , Pacheco Martha , Willen Faye , Yan Adam Paul , Harker-Murray Paul D. , Giulino-Roth Lisa 
Published: March 2023

Abstract
Outcomes for children and adolescents with relapsed and refractory Hodgkin lymphoma (HL) are poor, with ∼50% of patients experiencing a subsequent relapse. The anti-CD30 antibody–drug conjugate brentuximab vedotin improved progression-free survival (PFS) when used as consolidation after autologous stem cell transplantation (ASCT) in adults with high-risk relapsed/refractory HL. Data on brentuximab vedotin as consolidative therapy after ASCT in pediatric patients with HL are extremely limited, with data of only 11 patients reported in the literature. We performed a retrospective analysis of 67 pediatric patients who received brentuximab vedotin as consolidation therapy after ASCT for the treatment of relapsed/refractory HL to describe the experience of this regimen in the pediatric population. This is the largest cohort reported to date. We found that brentuximab vedotin was well tolerated with a safety profile similar to that of adult patients. With a median follow-up of 37 months, the 3-year PFS was 85%. These data suggest a potential role for the use of brentuximab vedotin as consolidation therapy after ASCT for children with relapsed/refractory HL.
Similarities and differences in the rhizosphere biota among different ephemeral desert plants in Gurbantünggüt Desert
Authors: Yang Yang , Liu Weiguo , Huang Tingwen , Yang Yaru 
Published: March 2023

Abstract
Background
The interactions between rhizosphere microbial community and ephemeral desert plants strongly affect the ecological protection, restoration and reconstruction in deserts. Ephemeral desert plants as the pioneer plants in the succession are widely distributed in deserts. However, how the ephemeral desert plants assemble their rhizosphere microbiota to adapt to arid and semi-arid environments has been little explored. Here, we used high-throughput sequencing techniques to compare rhizosphere bacterial communities and functions with different ephemeral desert plants composition from Gurbantünggüt Desert in western China.

Results
These plants had the same dominant bacterial phyla, which approximately counted 98% of the total bacterial communities. But the bacterial communities had significant differences (P < 0.05) in the composition, structure, diversity and functions of all groups. When comparing every two groups, similarities appeared in the composition, structure and functions of rhizosphere microbiota, and within each group, it is more likely that the rhizosphere bacterial communities of closely related ephemeral desert plants tend to be consistent. Additionally, the rhizosphere bacterial taxa had more similarities in predicted functions. And the predicted functions were correlated with the dominant bacterial phyla.

Conclusions
Overall, to adapt to the arid and semi-arid environments, the rhizosphere bacterial communities of ephemeral desert plants appear similarities based on having differences. This finding will help to understand the importance of how plants and soil microorganisms cooperate in the process of adaption to arid and semi-arid environments.
Gene expression during the formation of resting spores induced by nitrogen starvation in the marine diatom Chaetoceros socialis
Authors: Pelusi Angela , Ambrosino Luca , Miralto Marco , Chiusano Maria Luisa , Rogato Alessandra , Ferrante Maria Immacolata , Montresor Marina 
Published: March 2023

Abstract
Background
Dormancy is widespread in both multicellular and unicellular organisms. Among diatoms, unicellular microalgae at the base of all aquatic food webs, several species produce dormant cells (spores or resting cells) that can withstand long periods of adverse environmental conditions.

Results
We present the first gene expression study during the process of spore formation induced by nitrogen depletion in the marine planktonic diatom Chaetoceros socialis. In this condition, genes related to photosynthesis and nitrate assimilation, including high-affinity nitrate transporters (NTRs), were downregulated. While the former result is a common reaction among diatoms under nitrogen stress, the latter seems to be exclusive of the spore-former C. socialis. The upregulation of catabolic pathways, such as tricarboxylic acid cycle, glyoxylate cycle and fatty acid beta-oxidation, suggests that this diatom could use lipids as a source of energy during the process of spore formation. Furthermore, the upregulation of a lipoxygenase and several aldehyde dehydrogenases (ALDHs) advocates the presence of oxylipin-mediated signaling, while the upregulation of genes involved in dormancy-related pathways conserved in other organisms (e.g. serine/threonine-protein kinases TOR and its inhibitor GATOR) provides interesting avenues for future explorations.

Conclusions
Our results demonstrate that the transition from an active growth phase to a resting one is characterized by marked metabolic changes and provides evidence for the presence of signaling pathways related to intercellular communication.