bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE): an easy tool for investigating Self-Disorders, subjective experiences and global functioning
Authors: Magnani F. , Amorosi S. , Dell’Anna C. , Lucarini V. , Ballerini M. , Marchesi C. , Tonna M. 
Published: August 2023

IntroductionSelf Disorders (SDs) are regarded as the subjective phenotype of Schizophrenia vulnerability. The EASE (Examination of Anomalous Self-Experiences) scale is the most detailed and widely used instrument to investigate SDs, but it requires long administration times and specific training. The IPASE (Inventory of Psychotic-like Anomalous Self-Experiences) scale might be a self-administered instrument of widespread use for an easier SDs investigation.ObjectivesThe present study was aimed at validating the Italian version of IPASE, testing its internal consistency and usability for a first level SDs survey. A secondary objective was to confirm the correlations between IPASE, EASE, main symptom dimensions, subjective bodily experiences, symptoms of schizophrenic autism as well as levels of global functioning.MethodsFifty patients with Schizophrenia were administered the IPASE scale in its Italian version, the Examination of Anomalous Self-Experiences scale (EASE), the Positive And Negative Symptoms Scale (PANSS), the Social and Occupational Functioning Assessment Scale (SOFAS) to assess global functioning, the Autism Rating Scale (ARS) and the Abnormal Bodily Phenomena questionnaire (ABPq). The internal consistency of IPASE in its Italian version was investigated and the correlations between IPASE, EASE, ABP, ARS, PANSS and SOFAS were explored.ResultsThe internal consistency of the Italian version of IPASE was high (α 0.97). The IPASE and EASE total scores were positively correlated with each other, as were many of the conceptually related subdomains of both scales. The IPASE score was negatively correlated with global functioning (SOFAS) and positively correlated with total PANSS scores and with PANSS negative domain. Moreover, the IPASE total score was positively correlated with autism dimension (ARS), while anomalies in subjective experience of the lived body were coherently correlated with higher scores in IPASE “somatization” subdomain.Conclusions
The IPASE may be an easy instrument with high internal consistency for an initial investigation of SDs. IPASE domains appear to be correlated with the SDs investigated through EASE and with the main symptomatologic dimensions of Schizophrenia, in particular with negative symptoms. IPASE might also be a useful instrument for a first level investigation of subjective experiences concerning intersubjectivity and bodily dimensions.SDs are confirmed to be a core feature of the schizophrenia psychopathology, with a adverse impact on global functioning.Disclosure of InterestNone Declared
Correlates of aggressive behavior in the moroccan context
Authors: Tounsi A. , Bencharfa Z. , Azraf F. , Laboudi F. , Ouanass A. 
Published: August 2023

IntroductionViolence among the mentally ill population has long been a subject of stigma, and controversy. Clinicians’ ability to assess the violent potential is still limited.ObjectivesThe objective of this work is to identify the positively correlated indicators of aggressive behavior in patients admitted to hospital emergency departments.MethodsIt is a retrospective and descriptive paper based on the records of patients admitted to the emergency department of Arrazi University Psychiatric Hospital in Salé during a one-month period.The psychiatric diagnosis was formulated using the DSM-5 diagnostic criteria and Violent behavior was assessed using the Modified Overt Aggression Scale (MOAS). The existence of aggressive behavior was defined by a MOAS score ≥3.We used SPSS 15 to analyse resultsResultsSixty-five case files were selected during the study month. The average age was 35.3 (19;64).The mean of our sample MOAS aggression scale score was 31.5 [0; 79] and 90% of patients had a score ≥ 3 (image 1)Among the 65 admissions, heteroaggressive risk was the most frequent reason for hospitalization (N=53), followed by psychomotor excitement. IMAGE 2Statistical analysis revealed a significant association between high MOAS scores and substance use, history of suicide attempt, educational level and socioeconomic levelImage:Image 2:ConclusionsIn the current research, the prevalence of aggressive behavior was high among these patients, which may be due to the conditions of psychiatric hospitalization in our region, which is often reserved for the most serious and dangerous patients.Disclosure of InterestNone Declared
The efficacy of cognitive remediation in children and adolescents: results from a new meta-analysis.
Authors: Moscoso A. 
Published: August 2023

AbstractThis presentation will share data from a new meta-analysis of RCT studies using cognitive remediation to treat children and adolescents with ADHD. For this matter, 25 studies were accessed, and results will focus on outcomes immediately after the end of the program and in follow-up. Outcomes include subjective measures of functioning (through validated scales), neuropsychological measurements and academic performance. Comparisons regarding length of training, intensity, concomitant use of pharmacological treatments will also be provided. These findings will build on previous meta-analysis on the issue that were performed in the past.Disclosure of InterestNone Declared
Interplay between plasticity, environment and depression
Authors: Branchi I. 
Published: August 2023

AbstractPlasticity is the ability to modify brain and behavior, ultimately promoting an amplification of the impact of the environment on the individual’s mental health. Thus, plasticity is not beneficial per se but its value depends on contextual factors. High plasticity is beneficial in favorable, but can be detrimental in adverse living conditions, while the opposite applies to low plasticity. Consequently, resilience and vulnerability are not univocally associated to high or low plasticity. Here I will present recent findings supporting this theoretical framework and showing the role of the serotonin system in enhancing plasticity. First, we explored the Sequenced Treatment Alternatives to Relieve Depression-STAR*D dataset and analyzed the outcome of the SSRI citalopram treatment according to socioeconomic status (SES) and SSRI dosage. The results showed that SSRIs are plasticity-enhancer drugs as they amplify the influence of the living conditions on mood in a dose-dependent fashion. Second, we exploited a meta analytic approach to investigate the contribution of the serotonin-transporter-linked promoter region (5-HTTLPR) to depression vulnerability considering time as moderating factor. We found that the 5-HTTLPR x stress interaction is a dynamic process, producing different effects at different time points and confirming that individuals with high plasticity are both at higher risk and more capable to recover from depression. Overall, our findings indicate that treatments and conditions enhancing plasticity have a therapeutic value that depends on context.Disclosure of InterestNone Declared
Mental health and post-traumatic growth in multiple sclerosis
Authors: Gil-González I. , Pérez-San-Gregorio M. Á. , Martín-Rodríguez A. 
Published: August 2023

Introductionpeople suffering from multiple sclerosis (MS) can experience post-traumatic growth (PTG), a sense of personal growth and benefit gain. Patients mental health can play an important role in PTG development.Objectivesto explore possible differences in mental health according to PTG levels.Methodsthe sample was composed of 392 outpatients with MS from Virgen de la Macarena University Hospital (268 women; 124 (31.6 %) men, ages 19-78 years old (mean 45.61 years, SD=11.16 years). Expanded Disability Status Scale (EDSS) mean score was 3.38 (SD=2.06). Relapsing remittent (n=327) and progressive (n=65) MS type were reported. Post-traumatic Growth Inventory (PGI-21) measured patients perception of personal benefit gain after MS experience. General Health Questionnaire-28 (GHQ-28) evaluated Mental Health distress symptoms. Unpaired t-test was used to identify differences in mental health distress between “low PTG ≤49 score” and “high PTG ≥50 score” groups.ResultsSignificant differences were found in social dysfunction (t=2.521, p=0.012) and severe depression (t=2.442, p=0.015), “high PTG group” (n=194) presented lower scores compare to “low PTG group” (n=198). No significant difference was detected in somatic symptoms (t=0.185, p=0.087) and anxiety and insomnia (t=0.859, p=0.391).Conclusionspatients with higher PTG reported a better mental health. This suggests the relevance of mental health status in positive outcomes development after an adverse life event. Particularly, social dysfunction and depressive symptoms should be considered in interventions aimed to promote positive outcomes as personal gain and benefit finding in MS population.Disclosure of InterestNone Declared
Off-label use of atypical antipsychotics- Where are we?
Authors: Vaz R. P. , Martins J. , Costa A. L. , Brás J. , Sousa R. , Almeida E. , Abreu J. , Castro N. , Andrade R. , Gil N. 
Published: August 2023

IntroductionNowadays, In the exercise of psychiatric clinical activity, the prescription of atypical antipsychotics is a widespread practice.However, despite the approval in the treatment of psychoses and bipolar affective disorder, where its effectiveness is clearly demonstrated, these drugs are off-label prescribed in most of the clinical situations.ObjectivesThis work aims to clarify which atypical antipsychotics are most frequent prescribed and the clinical conditions where their off-label prescription is more common.MethodsBibliographic research in the Pubmed® database using the terms “atypical antipsychotics and off-label use”ResultsAccording to the scientific literature consulted, the off-label prescription of atypical antipsychotics may represent about 70% of the total prescription of these psychotropic drugs.Risperidone, olanzapine, quetiapine and aripiprazole are the most off-label prescribed among the atypical antipsychotics.The psychiatric conditions where atypical antipsychotics are most often off-label prescribed are addictive disorders, anxiety disorders, post-traumatic stress disorder, personality disorders, eating disorders, insomnia and dementia, where therapeutic benefits are demonstrated when carefully selected.ConclusionsThe off-label prescription can be interpreted from two points of view. On the one hand, it can guide innovation in clinical practice and improve symptoms in patients who do not respond to standard treatments. On the other hand, it may be associated with negative consequences due to the lack of data on safety and efficacy in these situations.Despite widespread prescribing of atypical antipsychotics, there is no evidence-based recommendation beyond psychoses and bipolar affective disorder.Thus, when prescribed, we must proceed with careful monitoring and consider the risks and benefits in relation to off-label prescription.Disclosure of InterestNone Declared
Coping Strategies and Relationship with Burnout among Residents in Thailand
Authors: Kusalaruk P. , Saravithi J. 
Published: August 2023

Introduction
Burnout is prevalent in residents and coping is one of the important modifying
factors.

Objectives
This study aimed to investigate coping strategies, burnout, and their relationship
among residents.

Methods
A cross-sectional descriptive study was conducted among residents from October 2019 to
April 2020 in Thailand. The Brief COPE Inventory Thai version and The Maslach Burnout
Inventory Thai version were used, and the associations between coping strategies and burnout
were examined.

Results
The number of 280 residents replied the questionnaire (response rate 41.5%). The most
favored copings were self-distraction and acceptance and the least common were denial and
substance use. Most residents had high level of emotional exhaustion (n = 113, 40.4%) and
moderate level of reduced personal accomplishment (n = 99, 35.4%). However, low degree of
depersonalization was reported predominantly (n = 164, 58.6%). The coping of venting,
behavioral disengagement and self-blame independently predicted emotional exhaustion and
depersonalization. Behavioral disengagement was the only predictor of burnout in all
dimensions, whereas positive reframing is the only strategy that had independent and
protective effect against burnout in all dimensions.
Table 1

Multivariate analysis of factors associated with emotional exhaustion

Variablesaassociated
with emotional exhaustion
β
(S.E.)
95%
CI
P
value

Venting
.17**
(.50)
(.50, 2.46)
< .01

Behavioral
disengagement
.29*** (.51)
(1.52, 3.55)
< .001

Self-blame
.15**
(.47)
(.30, 2.15)
.01

Planning
.15**
(.51)
(.32, 2.33)
.01

Positive
reframing
-.26*** (.50)
(-3.08, -1.12)
< .001

Table 2

Multivariate analysis of factors associated with depersonalization

Variablesaassociated
with depersonalization
β
(S.E.)
95%
CI
P
value

Sex
-.12* (.58)
(-2.37, -.07)
.04

Alcohol use
.18**
(.75)
(.74, 3.69)
< .01

Venting
.14* (.26)
(.07, 1.11)
.03

Behavioral
disengagement
.18**
(.25)
(.28, 1.27)
< .01

Self-blame
.21*** (.23)
(.38, 1.28)
< .001

Positive
reframing
-.18* (.23)
(-1.17, -.27)
< .01

Use instrumental
support
-.14* (.24)
(-1.03, -.10)
.02

Table 3

Multivariate analysis of factors associated with personal
accomplishment

Variablesaassociated
with personal accomplishment
β
(S.E.)
95%
CI
P
value

Behavioral
disengagement
-.13* (.38)
(-1.59, -.09)
.03

Positive
reframing
.21** (.41)
(.42, 2.03)
< .01

a
Only statistically significant variables are displayed

Conclusions
A large number of residents had emotional exhaustion. Behavioral disengagement and
positive reframing were the most influential coping strategies related to burnout. This study
might inform residency training program of some specific approaches for burnout
prevention.

Disclosure of Interest
None Declared
Benzodiazepine Prescription for Anxiety Disorders Increase the Risk of Substance Use Disorders: A Retrospective Cohort Study
Authors: Sun C.-F. , Lin Y. , Pola A. S. , Kablinger A. S. , Trestman R. L. 
Published: August 2023

IntroductionWhile the role of benzodiazepines (BZDs) has been well established for anxiety and related disorders, there are significant concerns about BZD dependence, withdrawal, and tolerance. There is a lot of ambiguity regarding the potential long-term effects of BZDs on mental health. However, the risk of developing subsequent other substance use disorders is in question.ObjectivesIn this electronic medical record (EMR) based retrospective cohort study, the study cohort was defined as patients between the ages of 18 and 65 with anxiety disorders (ICD-10-CM: F40-F48) prescribed with at least one BZD; the control cohort was defined as patients between the ages of 18 and 65 with anxiety disorders (ICD-10-CM: F40-F48) with no BZD prescription during the five-year timeframe examined. We excluded patients with pre-existing substance use disorders (ICD-10-CM: F10-F19), et al.MethodsWe collected data from TriNetX Research database, a real-time international EMR network, from September 2017 to September 2022. Patients in the two cohorts were matched by gender, age, race, ethnicity, and common medical conditions at a 1:1 ratio by propensity scoring and then underwent Kaplan–Meier analysis and association analysis.Results
A total of 626,754 patients were identified and matched for analysis. Patients in the study cohort were more likely to be female (67.6% vs. 66.7%, p < 0.001), non-Hispanic (65.8% vs. 62.5%, p < 0.001) and white (72.8% vs. 69.1%, p < 0.001). Kaplan–Meier analysis showed the survival probability at the end of the time window was 94.1% for the control cohort and 89.5% for the study cohort (Hazard ratio, 2.20; 95% CI, 2.16-2.25; P < 0.001) in all type of substance use disorders. (Table 1)
Table 1.Hazard ratio of substance use disorders difference in BZD cohort versus the control cohort.BZD Cohortn (risk%)Control Cohortn (risk%)Hazard Ratio(95% Cl)P valueSubstance Use Disorders*26,569 (4.2)11,976 (1.9)2.20 (2.16-
2.25)<0.001Sedative/hypnotic/anxiolytic related disorders656 (0.1)152 (0.0)4.26 (3.57- 5.09)<0.001Alcohol Related Disorder5,749 (0.9)2,064 (0.3)2.74 (2.61-2.88)<0.001Opioid Related Disorder2,807 (0.4)815 (0.1)3.38 (3.13-3.66)<0.001Stimulant Related Disorder1,658 (0.3)551 (0.1)2.94 (2.67- 3.24)<0.001Cannabis Related Disorder3,376 (0.5)970 (0.2)3.41 (3.17- 3.66)<0.001*Substance use disorders was defined as Mental and behavioral disorders due to psychoactive substance use (ICD-10-CM: F10-F19).ConclusionsPatients with an anxiety disorder who were prescribed BZDs are at higher risk of not only BZD dependence but all types of substance use disorders than a matched cohort not prescribed BZDs. Given this notable association, clinicians should be cautious while prescribing BZDs and inform the patient about the risks associated with their utilization.Disclosure of InterestNone Declared
Memory deficits in children and adolescents with psychotic disorders: A systematic review and meta-analysis
Authors: Rodríguez Toscano E. , Díaz-Carracedo P. , de la Higuera-González P. , Padilla G. , de la Torre-Luque A. 
Published: August 2023

IntroductionCognitive symptoms in psychosis represent a major unmet clinical need (Acuna-Vargas et al. Cog in Psych 2019; 21(3), 223–224). Deficit in memory has been largely described in first episode early onset psychosis (Mayoral et al. Eur Psych 2008; 23(5), 375-383) and has been associated to a worse functionality (Øie et al. Neuropsychology 2011; 25(1), 25–35). However, results from existing studies are quite mixed on memory deficits of early psychosis patients, particularly in terms of memory contents and storage resources.ObjectivesThe aims of this study were 1) to examine the nature and extent of cognitive impairment in early-onset psychosis and 2) to analyze which type of memory (verbal and visual) is more affected in the disorder.MethodsThe present systematic review and meta-analysis was conducted according to the PRISMA criteria (Moher et al. Systematic Reviews 2015; 4(1), 1 - 9). A systematic search of CINAHL, PsycInfo, PubMed, Redalyc, SCOPUS and Web of Science (published from 2000 to 2020) identified case-control studies of early onset psychotic disorder (under 18 years old). Those studies focused on both verbal and visual memory performance.ResultsTwenty articles were included in the review. A deficit in memory in child and adolescent psychotic disorders was obtained displaying a large effect size in memory tasks (g = -0.83). Also, a medium effect size was found in visual memory tasks (g = - 0.61) and a large effect size was found in verbal memory tasks (g = -1.00).ConclusionsIt was observed a strong memory deficit on early psychotic disorders already present at the onset of the illness. This deficit was stronger when verbal memory tasks were used compared to the effect found with visual memory tasks. Based on previous literature (García-Nieto et al. Jou Cli Child & Ado Psych 2011; 40(2), 266-280; Lepage et al. Eur Psych 2008; 23(5):368- 74; Hui et al. Psych Med 2016; 46(11):2435-44), these results contribute to describe and characterize the cognitive symptoms in the first-episode psychosis in a youth population.Disclosure of InterestNone Declared
Chronic activation of inflammasome signaling complexes and enhancement of behavioral abnormalities
Authors: Abdelmoula B. , Bouayed Abdelmoula N. 
Published: August 2023

IntroductionInflammasomes are cytosolic multi-component signaling platforms critical to the innate immune response to infectious diseases and the dysregulation of their activation can lead to the development of neurodegeneration and cancer.ObjectivesWe aim through this review to ass a possible interplay between dysregulation of inflammasome activation, development of chronic inflammatory disease and enhancement of behavioral abnormalities.MethodsWe comprehensively review the scientific literature using Pubmed database and other search platforms such as Google scholar to assess the role and the actors of chronic activation of inflammasome signaling complexes to establish a potential association between dysregulation of inflammasome activation, chronic inflammatory disease and enhancement of behavioral abnormalities.ResultsOur bibliographic review revealed that dysregulation of the inflammasome is associated with the onset and progression of several autoinflammatory and autoimmune diseases, including cryopyrin-associated periodic fever syndrome, familial Mediterranean fever, rheumatoid arthritis, and systemic lupus erythematosus. These multimeric complexes form in response to molecular patterns unique to pathogens and cellular damage, triggering a cascade of downstream responses, including the induction of pyroptotic cell death and release of proinflammatory cytokines. Some inflammasomes directly recognize these patterns, while others indirectly sense these patterns through changes in the homeostatic environment of the cell. Moreover, although being a normal part of the skin flora, yeasts of the genus Malassezia are associated with several inflammatory skin diseases including pityriasis versicolor (tinea versicolor), atopic eczema, psoriasis, Malassezia folliculitis and onychomycoses. In the context of tolerating fungi during colonization and eliciting, activation, of inflammasomes signaling complexes, has been identified as an integral part of antifungal host defense. While the activation of inflammasomes mainly the NLRP3 one, was shown to be pivotal for innate immunity against pathogenic fungi such as candida albicans, their role in the fungal genus Malassezia remains imprecise. Even though, many observations suggest that simultaneous activation of NLRP3, NLRC4 and AIM2 inflammasomes may play an important role.ConclusionsWhereas, chronic inflammasome activation such as by chronic infectious has been tied to the development of metabolic syndromes, neurodegenerative diseases, and cancer progression, a possible interplay between chronic invasion by the genus Malassezia, vigorous immune response to eliminate invading fungal pathogens, disruption of immune sensors of genotoxic stress, development of chronic inflammatory disease and behavioral abnormalities may be a new field of scientific researches.Disclosure of InterestNone Declared