bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESDE-MIE fellowship: a descriptive analysis of the first experiences
Authors: Talavera-Urquijo Eider , Gantxegi Amaia , Garbarino Giovanni M , Capovilla Giovanni , van Boxel Gijs I , Grimminger Peter P , Luyer Misha D , Markar Sheraz R , Svendsen Lars B , van Hillegersberg Richard 
Published: January 2023

Summary
Esophageal resection is a high-risk and technically demanding procedure, with a long proficiency-gain curve. The European Society Diseases of the Esophagus (ESDE)-Minimally Invasive Esophagectomy (MIE) training program was launched in 2018 for European surgeons willing to train and to begin a career undertaking MIE. The aim of this study was to evaluate the first experience of the ESDE-MIE fellowship and relate this to the initially predetermined core principles and objectives of the program. Between October 2021 and May 2022, the participating fellows, in collaboration with the ESDE Educational Committee, initiated a survey to assess the outcome and experience of these fellowships. Data from each individual fellowship were analysed and reported in a descriptive manner. Between 2018 and 2022, in total, five fellows have completed the ESDE-MIE fellowship program. Despite the COVID-19 outbreak just the year after its launch, predetermined clinical and research goals were achieved in all cases. Each of the fellows were able to assist in a median of 40 (IQR 27–69) MIE and/or Robot assisted (RA)MIE procedures, of a total median of 115 (IQR 83–123) attended Upper GI cases. After the fellowship, MIE has been fully adopted by the fellows who returned to their home institutions as Upper GI surgeons. The fellowship was concluded by the European Union of Medical Specialists (UEMS) Multidisciplinary Joint Committee (MJC) certification in Upper GI Surgery, which was successfully obtained by all who took part. Based on the experience of the first five fellows, the ESDE-MIE training fellowship meets with the expected needs even despite the COVID-19 outbreak in 2019. Furthermore, these fellows have returned home and integrated MIE into their independent surgical practice, affirming the ability of this program to train the next generation of MIE surgeons, even in the most challenging of circumstances.
Contemporary outcomes of esophageal and gastroesophageal junction neuroendocrine tumors
Authors: Poston Lauren M , Gupta Shreya , Alvarado Christine E , Sinopoli Jillian , Vargas Leonidas T , Linden Philip A , Towe Christopher W 
Published: January 2023

Abstract
Adenocarcinoma and squamous cell esophageal cancers have been extensively studied in the literature. Esophageal neuroendocrine (NET)/carcinoid tumors are less commonly studied and have only been described in small series. The purpose of this study was to describe the demographics and natural history of esophageal NETs, as well as optimal treatments. We hypothesized that surgical resection would be the best treatment of esophageal NETs. The National Cancer Database was used to identify adult patients with esophageal or gastroesophageal junction (GEJ) cancer from 2004 to 2018. Patients were characterized as carcinoid/NET, adenocarcinoma, or squamous cell cancer. Clinical and demographic characteristics were compared between the histology groups. The primary outcome was overall survival, which was assessed by multivariable Cox analysis. Multivariable Cox analysis was also used to analyze factors associated with survival among NET patients who underwent surgery. Among 206,321 patients with esophageal cancer, 1,563 were NETs (&lt;0.01%). Relative to the other two histologies, NETs were associated with younger age, female sex, and advanced clinical stage at diagnosis. Multivariate analysis suggested that NETs were less likely to be treated with surgical resection (OR 0.51, P &lt; 0.001). Nonetheless, surgical resection was associated with improved survival (HR 0.64, P = 0.003). Among patients with NETs who received surgery, neoadjuvant therapy was associated with improved overall survival (HR 0.38, P = 0.013). NET of the esophagus presents with more advanced disease than other common histologies. Among patients with nonmetastatic cancer, surgical resection appears to be the best treatment. Neoadjuvant systemic therapy may offer survival benefit, but future studies are necessary.
Thioguanine is Effective as Maintenance Therapy for Inflammatory Bowel Disease: A Prospective Multicentre Registry Study
Authors: Simsek Melek , Schepers Femke , Kaplan Sigal , van Asseldonk Dirk , van Boeckel Petra , Boekema Paul , Dijkstra Gerard , Fidder Herma , Gisbertz Ingrid , Hoentjen Frank , Jharap Bindia , Kubben Frank , de Leest Marleen , Meijssen Maarten , Petrak Ana , van de Poel Else , Russel Maurice , van Bodegraven Adriaan A , Mulder Chris J J , de Boer Nanne 
Published: January 2023

Abstract

Background and Aims
Thioguanine is a well-tolerated and effective therapy for inflammatory bowel disease [IBD] patients. Prospective effectiveness data are needed to substantiate the role of thioguanine as a maintenance therapy for IBD.

Methods
IBD patients who previously failed azathioprine or mercaptopurine and initiated thioguanine were prospectively followed for 12 months starting when corticosteroid-free clinical remission was achieved (Harvey–Bradshaw Index [HBI] ≤ 4 or Simple Clinical Colitis Activity Index [SCCAI] ≤ 2). The primary endpoint was corticosteroid-free clinical remission throughout 12 months. Loss of clinical remission was defined as SCCAI &gt; 2 or HBI &gt; 4, need of surgery, escalation of therapy, initiation of corticosteroids or study discontinuation. Additional endpoints were adverse events, drug survival, physician global assessment [PGA] and quality of life [QoL].

Results
Sustained corticosteroid-free clinical remission at 3, 6 or 12 months was observed in 75 [69%], 66 [61%] and 49 [45%] of 108 patients, respectively. Thioguanine was continued in 86 patients [80%] for at least 12 months. Loss of response [55%] included escalation to biologicals in 15%, corticosteroids in 10% and surgery in 3%. According to PGA scores, 82% of patients were still in remission after 12 months and QoL scores remained stable. Adverse events leading to discontinuation were reported in 11%, infections in 10%, myelo- and hepatotoxicity each in 6%, and portal hypertension in 1% of patients.

Conclusion
Sustained corticosteroid-free clinical remission over 12 months was achieved in 45% of IBD patients on monotherapy with thioguanine. A drug continuation rate of 80%, together with favourable PGA and QoL scores, underlines the tolerability and effectiveness of thioguanine for IBD.
Deep Learning in Population Genetics
Authors: Korfmann Kevin , Gaggiotti Oscar E , Fumagalli Matteo 
Published: January 2023

Abstract
Population genetics is transitioning into a data-driven discipline thanks to the availability of large-scale genomic data and the need to study increasingly complex evolutionary scenarios. With likelihood and Bayesian approaches becoming either intractable or computationally unfeasible, machine learning, and in particular deep learning, algorithms are emerging as popular techniques for population genetic inferences. These approaches rely on algorithms that learn non-linear relationships between the input data and the model parameters being estimated through representation learning from training data sets. Deep learning algorithms currently employed in the field comprise discriminative and generative models with fully connected, convolutional, or recurrent layers. Additionally, a wide range of powerful simulators to generate training data under complex scenarios are now available. The application of deep learning to empirical data sets mostly replicates previous findings of demography reconstruction and signals of natural selection in model organisms. To showcase the feasibility of deep learning to tackle new challenges, we designed a branched architecture to detect signals of recent balancing selection from temporal haplotypic data, which exhibited good predictive performance on simulated data. Investigations on the interpretability of neural networks, their robustness to uncertain training data, and creative representation of population genetic data, will provide further opportunities for technological advancements in the field.
Cohort Trajectories by Age and Gender for Informal Caregiving in Europe Adjusted for Sociodemographic Changes, 2004 and 2015
Authors: Rodrigues Ricardo , Rehnberg Johan , Simmons Cassandra , Ilinca Stefania , Zólyomi Eszter , Vafaei Afshin , Kadi Selma , Jull Janet , Phillips Susan P , Fors Stefan 
Published: January 2023

Abstract

Objectives
We present a dynamic view of gender patterns in informal caregiving across Europe in a context of sociodemographic transformations. We aim to answer the following research questions: (a) has the gender gap in informal caregiving changed; (b) if so, is this due to changes among women and/or men; and (c) has the gender care gap changed differently across care regimes?

Methods
Multilevel growth curve models are applied to gendered trajectories of informal caregiving of a panel sample of 50+ Europeans, grouped into 5-year cohorts and followed across 5 waves of the Survey of Health, Ageing and Retirement in Europe survey, stratified by sex and adjusted for several covariates.

Results
For men in cohorts born more recently, there is a decrease in the prevalence of informal care outside the household, whereas cohort trajectories for women are mostly stable. Prevalence of care inside the household has increased for later-born cohorts for all without discernible changes to the gender care gap. Gender care gaps overall widened among later-born cohorts in the Continental cluster, whereas they remained constant in Southern Europe, and narrowed in the Nordic cluster.

Discussion
We discuss the cohort effects found in the context of gender differences in employment and care around retirement age, as well as possible demographic explanations for these. The shift from care outside to inside the household, where it mostly consists of spousal care, may require different policies to support carers, whose age profile and possible care burden seem to be increasing.
The politics of press astrology in wartime Britain, 1939–42
Authors: Parken Oliver 
Published: January 2023

Abstract
This article explores the politics of popular press astrology between 1939 and 1942. Charting the astrological content of the News of the World, The People, the Sunday Dispatch, the Sunday Express and the Sunday Pictorial, it unearths connections between predictions and wider themes of morale and press freedoms during the war. The article argues that these predictions, which were largely aimed at female readers, were, on balance, morale-boosting. Fears over the impact of press astrology speak to anxieties over the influence of popular newspapers in wartime among officials and contemporary researchers.
Inflammatory Bowel Disease Among Canadian Children: Comparison Between Children of Non-European Descent and Children of European Descent
Authors: Jeong Jocelyn , Walters Thomas D , Huynh Hien Q , Lawrence Sally , Mack David R , Deslandres Colette , Otley Anthony , El-Matary Wael , Sherlock Mary , Griffiths Anne M , Wine Eytan , Jacobson Kevan , Church Peter , Carroll Matthew W , Benchimol Eric I , Brill Herbert , Critch Jeff , Bax Kevin , Jantchou Prévost , Rashid Mohsin , Kaplan Gilaad G , Seow Cynthia H , Novak Kerri , deBruyn Jennifer C 
Published: January 2023

Abstract

Background
Inflammatory bowel disease (IBD) phenotypes may differ between countries and ancestral groups. The study aim was to examine ancestry and subtype variations of children newly diagnosed with IBD.

Methods
Children newly diagnosed with IBD enrolled into the Canadian Children Inflammatory Bowel Disease Network inception cohort study were categorized into 8 ancestral groups. Prospectively collected data at diagnosis and follow-up were compared between ancestral groups.

Results
Among 1447 children (63.2% Crohn’s disease, 30.7% ulcerative colitis), 67.8% were European, 9.4% were South Asian, 3.8% were West Central Asian and Middle Eastern, 2.3% were African, 2.2% were East/South East Asian, 2.0% were Caribbean/Latin/Central/South American, 9.9% were mixed, and 2.6% were other. Children of African descent with ulcerative colitis had an older age of diagnosis compared with children of European descent (median 15.6 years vs 13.3 years; P = .02). Children of European descent had a higher proportion of positive family history with IBD (19.3% vs 12.1%; P = .001) compared with children of non-European descent. Children of European descent also had a lower proportion of immigrants and children of immigrants compared with children of non-European descent (9.8% vs 35.9%; P &lt; .0001; and 3.6% vs 27.2%; P &lt; .0001, respectively) .

Conclusions
Important differences exist between different ancestral groups in pediatric patients with IBD with regard to age of diagnosis, family history, and immigrant status. Our study adds to the knowledge of the impact of ancestry on IBD pathogenesis.
Documentation quality of patient-directed discharge and early warning interactions in an adult inpatient service
Authors: Jeyaraju Maniraj , Salvatori Cristiana Grace , George Nivya , Schmalzle Sarah Ann 
Published: January 2023

AbstractDocumentation quality of patient–physician discussion, assessment, and intervention at the time of patient-directed discharges (elopement and ‘against medical advice’ discharges) is found to be poor in available studies and, importantly, may be a proxy for quality of care delivered. Less is known about the patient–physician interactions and documentation at the time a patient vocalizes the desire to leave early (‘early warning interaction’) prior to a patient-directed discharge. This was a cohort study comprising a retrospective chart review of patients leaving ‘against medical advice’ from an inpatient internal medicine—infectious disease service at a tertiary medical center from 01 July 2020 to 24 September 2021. Documentation quality was assessed using 11 extractable factors detailing patient–physician conversation elements from the assess, investigate, mitigate, explain, and document framework, plus related interventions pertinent to patient safety and care optimization. Descriptive statistics were mainly utilized with inferential statistics and regression models as appropriate. Fifty-two patients left against medical advice and 49 eloped; 11% had an early warning interaction. Aggregate documentation quality scores at early warning interaction (13%), ‘against medical advice’ discharge (42%), and at elopement (31%) were low. Half of the suggested documentation elements were recorded in no patients. The overall documentation quality was poor, suggesting the need for further training and interventions to facilitate more thorough documentation.
The Past, Present, and Future(s) of Feminist Foreign Policy
Authors: Achilleos-Sarll Columba , Thomson Jennifer , Haastrup Toni , Färber Karoline , Cohn Carol , Kirby Paul 
Published: January 2023

AbstractAlmost a decade after Sweden first declared that it would follow a feminist foreign policy (FFP), a further eleven countries from across Europe, North and South America, and North and West Africa have adopted, or have signaled an interest in potentially adopting, an FFP in the future. These developments have been accompanied by a growing body of feminist scholarship. Although still in its infancy, this literature can generally be divided between more normative accounts and those that are empirically focused, with particular attention paid to the FFPs of Sweden and Canada. Yet, few studies compare FFPs’ uptake across different countries and regions, examine its connections to longer histories of ideas around women and gender, or unpack the policy intersections FFP (tentatively) engages. Contributing to these different areas, Part I provides an overview of the history of FFP, interrogates FFP in the context of Foreign Policy Analysis, and explores what FFP can achieve in the current (liberal) global system. Part II turns to consider policy intersections in relation to the climate crisis, migration, militarism, and bodies. Thinking through its origins, policy intersections, and potential future(s), the contributors to this Forum explore FFP's multiple and contested future(s). Ultimately, the Forum takes stock of this feminist turn in foreign policy at a critical point in its development and considers what future possibilities it may hold.
“Mm-hm,” “Uh-uh”: are non-lexical conversational sounds deal breakers for the ambient clinical documentation technology?
Authors: Tran Brian D , Latif Kareem , Reynolds Tera L , Park Jihyun , Elston Lafata Jennifer , Tai-Seale Ming , Zheng Kai 
Published: January 2023

AbstractObjectivesAmbient clinical documentation technology uses automatic speech recognition (ASR) and natural language processing (NLP) to turn patient–clinician conversations into clinical documentation. It is a promising approach to reducing clinician burden and improving documentation quality. However, the performance of current-generation ASR remains inadequately validated. In this study, we investigated the impact of non-lexical conversational sounds (NLCS) on ASR performance. NLCS, such as Mm-hm and Uh-uh, are commonly used to convey important information in clinical conversations, for example, Mm-hm as a “yes” response from the patient to the clinician question “are you allergic to antibiotics?”Materials and MethodsIn this study, we evaluated 2 contemporary ASR engines, Google Speech-to-Text Clinical Conversation (“Google ASR”), and Amazon Transcribe Medical (“Amazon ASR”), both of which have their language models specifically tailored to clinical conversations. The empirical data used were from 36 primary care encounters. We conducted a series of quantitative and qualitative analyses to examine the word error rate (WER) and the potential impact of misrecognized NLCS on the quality of clinical documentation.ResultsOut of a total of 135 647 spoken words contained in the evaluation data, 3284 (2.4%) were NLCS. Among these NLCS, 76 (0.06% of total words, 2.3% of all NLCS) were used to convey clinically relevant information. The overall WER, of all spoken words, was 11.8% for Google ASR and 12.8% for Amazon ASR. However, both ASR engines demonstrated poor performance in recognizing NLCS: the WERs across frequently used NLCS were 40.8% (Google) and 57.2% (Amazon), respectively; and among the NLCS that conveyed clinically relevant information, 94.7% and 98.7%, respectively.Discussion and ConclusionCurrent ASR solutions are not capable of properly recognizing NLCS, particularly those that convey clinically relevant information. Although the volume of NLCS in our evaluation data was very small (2.4% of the total corpus; and for NLCS that conveyed clinically relevant information: 0.06%), incorrect recognition of them could result in inaccuracies in clinical documentation and introduce new patient safety risks.
MIMIC-IV on FHIR: converting a decade of in-patient data into an exchangeable, interoperable format
Authors: Bennett Alex M , Ulrich Hannes , van Damme Philip , Wiedekopf Joshua , Johnson Alistair E W 
Published: January 2023

AbstractObjectiveConvert the Medical Information Mart for Intensive Care (MIMIC)-IV database into Health Level 7 Fast Healthcare Interoperability Resources (FHIR). Additionally, generate and publish an openly available demo of the resources, and create a FHIR Implementation Guide to support and clarify the usage of MIMIC-IV on FHIR.Materials and MethodsFHIR profiles and terminology system of MIMIC-IV were modeled from the base FHIR R4 resources. Data and terminology were reorganized from the relational structure into FHIR according to the profiles. Resources generated were validated for conformance with the FHIR profiles. Finally, FHIR resources were published as newline delimited JSON files and the profiles were packaged into an implementation guide.ResultsThe modeling of MIMIC-IV in FHIR resulted in 25 profiles, 2 extensions, 35 ValueSets, and 34 CodeSystems. An implementation guide encompassing the FHIR modeling can be accessed at mimic.mit.edu/fhir/mimic. The generated demo dataset contained 100 patients and over 915 000 resources. The full dataset contained 315 000 patients covering approximately 5 840 000 resources. The final datasets in NDJSON format are accessible on PhysioNet.DiscussionOur work highlights the challenges and benefits of generating a real-world FHIR store. The challenges arise from terminology mapping and profiling modeling decisions. The benefits come from the extensively validated openly accessible data created as a result of the modeling work.ConclusionThe newly created MIMIC-IV on FHIR provides one of the first accessible deidentified critical care FHIR datasets. The extensive real-world data found in MIMIC-IV on FHIR will be invaluable for research and the development of healthcare applications.
Undermining Desire: Reducing Unhealthy Choices by Highlighting Short-Term (vs. Long-Term) Costs
Authors: Stillman Paul E , Woolley Kaitlin 
Published: January 2023

Abstract
What motivates consumers to avoid unhealthy behaviors (e.g., consuming sugar, energy drinks, and fast food)? Traditional interventions and lay intuition suggest that to motivate themselves, consumers can consider the negative long-term health consequences of their decisions. Yet, consumers still struggle to avoid unhealthy behaviors. Seven experiments (N = 4,021) offer a different approach. We find that considering short-term costs of unhealthy behaviors (e.g., irritability or indigestion after eating sugar) better curbs these behaviors than considering long-term costs or no costs. We theorize that short-term costs are more effective at reducing unhealthy behavior because they are more strongly associated with the act of consumption, both in terms of immediate timing and perceived likelihood of costs occurring. As such, short-term costs are better at undermining the reason for consuming unhealthily: anticipated enjoyment of the consumption experience. We test this process by (a) demonstrating mediation via increased association strength and subsequent decreased anticipated enjoyment, (b) manipulating the association strength between consumption and costs (i.e., same cost realized sooner vs. later), and (c) demonstrating moderation via consumers’ goal for eating unhealthily. These results identify a powerful but underutilized self-regulation strategy—emphasizing short-term costs of unhealthy consumption—with implications for consumers and marketers.
Multilevel longitudinal analysis of social networks
Authors: Koskinen Johan , Snijders Tom A B 
Published: January 2023

AbstractStochastic actor-oriented models (SAOMs) are a modelling framework for analysing network dynamics using network panel data. This paper extends the SAOM to the analysis of multilevel network panels through a random coefficient model, estimated with a Bayesian approach. The proposed model allows testing theories about network dynamics, social influence, and interdependence of multiple networks. It is illustrated by a study of the dynamic interdependence of friendship networks and minor delinquency. Data were available for 126 classrooms in the first year of secondary school, of which 82 were used, containing relatively few missing data points and having not too much network turnover.