bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biochemical Methods for the Characterisation of Walnut Genotypes with Different Levels of Frost Tolerance
Authors: Bartha Krisztina Szügyi , Bujdosó Géza , Stefanovits-Bányai Éva 
Published: January 2023

AbstractIn plants, stress induces changes in peroxidase enzymes, which play various physiological roles, including involvement in the development of resistance. Experiments were performed at the Elvira major Experimental Station of the NARIC Research Institute for Fruitgrowing and Ornamentals in Érd, Hungary, on two genotypes selected in Hungary (‘Alsószentiváni 117’ and ‘Milotai 10’), on the Californian-bred cultivar ‘Pedro’, and two genotypes bred in Hungary by crossing ‘Pedro’ with the two Hungarian selections: ‘Milotai intenzív’ and ‘Alsószentiváni kései’. These genotypes were chosen on the basis of frost tolerance. Measurements were made on the peroxidase activity and total polyphenol content in the leaves during sprouting (May 2nd, 12th and 20th 2016) and in the uppermost internode of the shoots (November, December 2016; January 2017). Higher peroxidase enzyme activity and polyphenol content in the uppermost internode were good indicators of the frost tolerance of the genotypes and of the stress level to which they were exposed.
National archives, national memory? How national archives describe themselves and their mission
Authors: Rydén Reine 
Published: January 2023

AbstractThere is a widespread notion that archives, especially national archival institutions, represent the nation’s memory. Historically, archives have played an important role for history writing, thereby contributing to the construction of national master narratives and the strengthening of national identities. What the association between archives and memory actually means is however debated in archival literature. Taking the discussion on the relation between archives and memory as a starting point, this study examines how national archives in today’s world present themselves to the public. The source material consists of mission statements collected from 138 webpages and 18 Facebook accounts all over the world. The first research question concerns the connection between mission statements and a national master narrative, the second asks where references to national memory and national identity are most pronounced, and the third asks whether self-images of national archives can be connected to historical experiences. The analysis shows that mission statements contain many allusions to history and heritage, while references to memory and identity are less widespread than expected. Some variations between continents, and between different groups of countries are identified, although relatively small. A possible explanation is that national archives are engaged in quite a lot of international cooperation, for instance in the International Council on Archives and UNESCO. Thus, they are likely to be as much influenced by each other as by the political environment in their own countries.
Prevalence and Comorbidity of Gender Dysphoria in Taiwan, 2010–2019
Authors: Chao Kuo-Yu , Chou Chih-Chiang , Chen Ching-I. , Lee Shu-Ru , Cheng Wei 
Published: January 2023

AbstractGender dysphoria (GD) is a condition in which a person exhibits marked incongruence between their expressed or experienced gender and their sex assigned at birth. The last survey of individuals with GD in Taiwan was conducted approximately 10 years ago. In this study, we investigated the prevalence of GD in Taiwan within the last 10 years as well as comorbidities. A retrospective medical record review was performed for all patients in the database of the Health and Welfare Data Science Center covered by National Health Insurance in Taiwan from January 2010 until December 2019. The study population of persons with GD was defined as individuals who had been diagnosed with transsexualism (transgender or transsexual) or gender identity disorders. Our review found case numbers and prevalence of GD in 2019 were about twice that of patients in 2010 for both assigned males and assigned females at birth. Case numbers for 2010 versus 2019 were 440 versus 867 for assigned males at birth, and 189 versus 386 for assigned females at birth. The 1-year prevalence for 2010 versus 2019 was 3.8/100,000 versus 7.4/100,000 for assigned males at birth, and 1.6/100,000 versus 3.2/100,000 for assigned females at birth. Comorbidities of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and psychosis were more likely in children with GD younger than 12 years of age; comorbid depression was more likely in adolescents and adults with GD. Improvements in social and mental health support should be provided to help address these comorbidities of ADHD, ASD, and depression among individuals with GD.
Hydrogen Lyman-Alpha Periodicity Behaviour During Various Solar Cycles
Authors: Kotzé Pieter 
Published: January 2023

AbstractThe temporal behaviour of various periodicities of hydrogen Lyman-alpha (Ly-$\alpha $
α
) between 1950 and 2020 have been analysed using Lomb-Scargle and Morlet wavelets spectral analysis techniques. Daily mean values of Ly-$\alpha $
α
radiance (https://lasp.colorado.edu/lisird/data/composite_lyman_alpha/) for each individual year were used in this investigation to obtain the temporal behaviour of particularly the Rieger periodicity (150–180 days), the synodic solar rotation periodicity ($\approx27$
≈
27
days) as well as the elusive 13.5-day periodicity. Results obtained showed that the Rieger periodicity dominates at solar maximum during strong solar cycle conditions (Cycles 19, 21, 22, and 23), while the $\approx27$
≈
27
-day periodicity is in most cases dominant during solar minima. On the other hand, the 13.5-day periodicity only appears above the 95% statistical confidence level during solar maxima of Cycles 19, 21, 22 and 24. Contrary to all previous Cycles since 1950, the 13.5-day periodicity appears exceptionally strong and above the 95% confidence level during the downward and minimum phases of Cycles 23 (2006) and 24 (2016) when its power exceeds that of the 27-day periodicity. This peculiar behaviour of the 13.5-day periodicity in Ly-$\alpha $
α
can probably be attributed to the anomalous asymmetrical structure of the solar magnetic field during Cycles 23 and 24.
A conceptual model of what programming affords secondary school courses in mathematics and technology
Authors: Humble Niklas 
Published: January 2023

Abstract
Due to increased need of professionals on the future labour market with competence in programming, many countries have integrated programming in kindergarten to grade 12 (K-12) education. In 2017, programming was integrated in Swedish primary and secondary school curriculum and the courses of Mathematics and Technology. Research has highlighted challenges in integrating programming and other new technologies, and the need for better teacher support. The aim of the study was to examine what programming affords secondary school courses in Mathematics and Technology according to teachers that use programming in these two courses. The study was conducted with a qualitative approach and collected data through interviews with 19 teachers that use programming in secondary school courses of Mathematics and/or Technology. Thematic analysis with inductive-deductive approach was used to analyse the collected data. Theory of Affordances was used to identify themes of interests in the collected material and group these into categories. Ten programming affordances are identified in this study: 1) flexibility, 2) creativity, 3) efficiency, 4) visualisation, 5) fun, 6) curiosity, 7) play, 8) holistic views, 9) fearlessness, and 10) interdisciplinary collaborations. Through discussion and comparison with previous research, these programming affordances are found to relate to three aspects of teaching and learning in secondary school Mathematics and Technology: A) support course content and learning, B) facilitate engagement and motivation, and C) foster developmental skills. The study concludes with a suggestion for a conceptual model on what programming can afford school courses in Mathematics and Technology, based on the findings of the study. Findings can be used by teachers, policymakers and other stakeholders in the integration and design of programming in secondary education.
How Strong Is the Evidence for a Causal Reciprocal Effect? Contrasting Traditional and New Methods to Investigate the Reciprocal Effects Model of Self-Concept and Achievement
Authors: Hübner Nicolas , Wagner Wolfgang , Zitzmann Steffen , Nagengast Benjamin 
Published: January 2023

AbstractThe relationship between students’ subject-specific academic self-concept and their academic achievement is one of the most widely researched topics in educational psychology. A large proportion of this research has considered cross-lagged panel models (CLPMs), oftentimes synonymously referred to as reciprocal effects models (REMs), as the gold standard for investigating the causal relationships between the two variables and has reported evidence of a reciprocal relationship between self-concept and achievement. However, more recent methodological research has questioned the plausibility of assumptions that need to be satisfied in order to interpret results from traditional CLPMs causally. In this substantive-methodological synergy, we aimed to contrast traditional and more recently developed methods to investigate reciprocal effects of students’ academic self-concept and achievement. Specifically, we compared results from CLPMs, full-forward CLPMs (FF-CLPMs), and random intercept CLPMs (RI-CLPMs) with two weighting approaches developed to study causal effects of continuous treatment variables. To estimate these different models, we used rich longitudinal data of N = 3757 students from lower secondary schools in Germany. Results from CLPMs, FF-CLPMs, and weighting methods supported the reciprocal effects model, particularly when math self-concept and grades were considered. Results from the RI-CLPMs were less consistent. Implications from our study for the interpretation of effects from the different models and methods as well as for school motivation theory are discussed.
Harmony, Disruption, and Affective Injustice: Metz and the Capacity for Harmonious Relationship
Authors: Carman Mary 
Published: January 2023

AbstractIn A Relational Moral Theory: African ethics in and beyond the continent (2022), Thaddeus Metz proposes an African moral theory according to which we ought to respect and honour the capacity of individuals to be party to harmonious relationship. He aims to present a moral theory that should ‘be weighed up against at least contemporary Western moral theories’ (p. 2). As Metz intends his theory to be a serious contender with other moral theories, I assess how his moral theory can be applied and contribute to contemporary moral discussions ‘beyond the continent’, as the subtitle of the book puts it. In particular, as Metz’s relational moral theory is grounded on the value of harmony, an important question is how well his theory handles disharmony especially if his theory is to have application in our non-ideal world in which disharmony is rife. And here, I hold up Metz’s account to one area of disharmony, disruptive emotions and affective injustice. By first establishing how disruptive emotions and affective injustice pose a challenge to similar relational moral theories grounded in harmony, I argue that Metz’s theory has distinct advantages in the way in which it can indeed engage with such phenomena. I close the paper by considering the objection that Metz’s account is limited in making sense of a common form of disruptive emotion in response to structural injustices where affective injustice can arise, but ultimately conclude that such a limitation is superficial.
Optimised Spintronic Emitters of Terahertz Radiation for Time-Domain Spectroscopy
Authors: Wagner Ford M. , Melnikas Simas , Cramer Joel , Damry Djamshid A. , Xia Chelsea Q. , Peng Kun , Jakob Gerhard , Kläui Mathias , Kičas Simonas , Johnston Michael B. 
Published: January 2023

AbstractSpintronic metal thin films excited by femtosecond laser pulses have recently emerged as excellent broadband sources of terahertz (THz) radiation. Unfortunately, these emitters transmit a significant proportion of the incident excitation laser, which causes two issues: first, the transmitted light can interfere with measurements and so must be attenuated; second, the transmitted light is effectively wasted as it does not drive further THz generation. Here, we address both issues with the inclusion of a high-reflectivity (HR) coating made from alternating layers of SiO2 and Ta2O5. Emitters with the HR coating transmit less than 0.1% of the incident excitation pulse. Additionally, we find that the HR coating increases the peak THz signal by roughly 35%, whereas alternative attenuating elements, such as cellulose nitrate films, reduce the THz signal. To further improve the emission, we study the inclusion of an anti-reflective coating to the HR-coated emitters and find the peak THz signal is enhanced by a further 4%.
Longitudinal Linkages Between Parent-Child Discrepancies in Reports on Parental Autonomy Support and Informants’ Depressive Symptoms
Authors: Vrolijk Paula , Van Lissa Caspar J. , Branje Susan , Keizer Renske 
Published: January 2023

AbstractAlthough parent-child discrepancies in reports of parenting are known to be associated with child depressive symptoms, the direction of causality is unknown. To address this knowledge gap, this study contributes to existing literature by examining longitudinal within-family linkages between parent-child discrepancies in their reports on autonomy support and depressive symptoms of children, while also assessing these linkages with parents’ depressive symptoms. In addition, this study explored whether these linkages differ for father- versus mother-child discrepancies. Longitudinal data (six annual waves) of 497 adolescents (56.9% boys, Mage at T1 = 13.03, SD = 0.46), their mothers (N = 495), and their fathers (N = 446) of the Dutch study Research on Adolescent Development and Relationships (RADAR) were used. Counter to expectations, the results of a Random Intercept Cross-Lagged Panel Model provided no evidence for within-family cross-lagged effects. Instead, stable differences between families explained linkages; in families where children reported on average higher levels of depressive symptoms, children also reported lower levels of autonomy support relative to their parents. There were no associations between parent-child discrepancies and parents’ depressive symptoms. Thus, the findings suggest that depressive symptoms are neither a consequence, nor a predictor of parent-child discrepancies in adolescence. The hypotheses and analytical plan of this study were preregistered in a project on the Open Science Framework.
Higher research productivity = more pay? Gender pay-for-productivity inequity across disciplines
Authors: Samaniego Charissa , Lindner Peggy , Kazmi Maryam A. , Dirr Bobbie A. , Kong Dejun Tony , Jeff-Eke Evonzia , Spitzmueller Christiane 
Published: January 2023

AbstractGender pay equity for academics continues to be elusive. Adding to scholarship around structural barriers to gender equity in academic settings, we investigate the link between scholarly performance and compensation. We expect high research productivity to be differentially associated with compensation outcomes for men and women. Building on social role theory, we hypothesize that these relationships are contingent upon whether researchers are inside or outside of Science, Technology, Engineering, and Mathematics (STEM). Using the h-index, compensation, and researcher demographics for 3033 STEM and social and behavioral sciences (SBS) researchers from 17 R1 universities, we applied multilevel modeling techniques and showed that cumulative research productivity was more strongly related to compensation for men versus women researchers. However, these effects only held in STEM disciplines but not in SBS disciplines. Based on these results, we recommend that institutions consider changing how pay analyses are conducted and advocate for adding explicit modeling of scientific performance-compensation links as part of routine pay equity analyses.
Accelerated ageing and coronary microvascular dysfunction in chronic heart failure in Tgαq*44 mice
Authors: Berkowicz Piotr , Totoń-Żurańska Justyna , Kwiatkowski Grzegorz , Jasztal Agnieszka , Csípő Tamás , Kus Kamil , Tyrankiewicz Urszula , Orzyłowska Anna , Wołkow Paweł , Tóth Attila , Chlopicki Stefan 
Published: January 2023

AbstractAge represents a major risk factor in heart failure (HF). However, the mechanisms linking ageing and HF are not clear. We aimed to identify the functional, morphological and transcriptomic changes that could be attributed to cardiac ageing in a model of slowly progressing HF in Tgαq*44 mice in reference to the cardiac ageing process in FVB mice. In FVB mice, ageing resulted in the impairment of diastolic cardiac function and in basal coronary flow (CF), perivascular and interstitial fibrosis without changes in the cardiac activity of angiotensin-converting enzyme (ACE) or aldosterone plasma concentration. In Tgαq*44 mice, HF progression was featured by the impairment of systolic and diastolic cardiac function and in basal CF that was associated with a distinct rearrangement of the capillary architecture, pronounced perivascular and interstitial fibrosis, progressive activation of cardiac ACE and systemic angiotensin-aldosterone-dependent pathways. Interestingly, cardiac ageing genes and processes were represented in Tgαq*44 mice not only in late but also in early phases of HF, as evidenced by cardiac transcriptome analysis. Thirty-four genes and 8 biological processes, identified as being ageing related, occurred early and persisted along HF progression in Tgαq*44 mice and were mostly associated with extracellular matrix remodelling and fibrosis compatible with perivascular fibrosis resulting in coronary microvascular dysfunction (CMD) in Tgαq*44 mice. In conclusion, accelerated and persistent cardiac ageing contributes to the pathophysiology of chronic HF in Tgαq*44 mice. In particular, prominent perivascular fibrosis of microcirculation resulting in CMD represents an accelerated cardiac ageing phenotype that requires targeted treatment in chronic HF.
Human antibody profiling technologies for autoimmune disease
Authors: Carlton Lauren H. , McGregor Reuben , Moreland Nicole J. 
Published: January 2023

AbstractAutoimmune diseases are caused by the break-down in self-tolerance mechanisms and can result in the generation of autoantibodies specific to human antigens. Human autoantigen profiling technologies such as solid surface arrays and display technologies are powerful high-throughput technologies utilised to discover and map novel autoantigens associated with disease. This review compares human autoantigen profiling technologies including the application of these approaches in chronic and post-infectious autoimmune disease. Each technology has advantages and limitations that should be considered when designing new projects to profile autoantibodies. Recent studies that have utilised these technologies across a range of diseases have highlighted marked heterogeneity in autoantibody specificity between individuals as a frequent feature. This individual heterogeneity suggests that epitope spreading maybe an important mechanism in the pathogenesis of autoimmune disease in general and likely contributes to inflammatory tissue damage and symptoms. Studies focused on identifying autoantibody biomarkers for diagnosis should use targeted data analysis to identify the rarer public epitopes and antigens, common between individuals. Thus, utilisation of human autoantigen profiling technology, combined with different analysis approaches, can illuminate both pathogenesis and biomarker discovery.
Phase 2 results of idecabtagene vicleucel (ide-cel, bb2121) in Japanese patients with relapsed and refractory multiple myeloma
Authors: Minakata Daisuke , Ishida Tadao , Ando Kiyoshi , Suzuki Rikio , Tanaka Junji , Hagiwara Shotaro , Ananthakrishnan Revathi , Kuwayama Shigeki , Nishio Mitsufumi , Kanda Yoshinobu , Suzuki Kenshi 
Published: January 2023

Abstract
Background
In the phase 2 KarMMa trial, patients with relapsed/refractory multiple myeloma (RRMM) achieved deep and durable responses with idecabtagene vicleucel (ide-cel), a B-cell maturation antigen-directed chimeric antigen receptor (CAR) T cell therapy. Here we report a sub-analysis of the Japanese cohort of KarMMa.

Methods
Adult patients with RRMM who had received ≥ 3 prior treatment regimens, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 antibody, and had disease refractory to last treatment received ide-cel at a target dose of 450 × 106 CAR positive T cells.

Results
Nine patients were treated with ide-cel. The overall response rate was 89% (median follow-up, 12.9 months). The best overall response was stringent complete response in 5 patients (56%), very good partial response in 3 (33%), and stable disease in 1. Median duration of response was not reached. All patients experienced grade ≤ 2 cytokine release syndrome and one patient experienced grade 2 neurotoxicity, but all resolved. Two patients died, one each from plasma cell myeloma and general health deterioration.

Conclusion
Ide-cel yielded deep, durable responses with a tolerable and predictable safety profile in Japanese patients with RRMM. These results are similar to those of the non-Japanese population in KarMMa.
Transglycosylation of Stevioside by a Commercial β-Glucanase with Fungal Extracted β-Glucans as Donors
Authors: Zerva Anastasia , Mohammadi Milad , Dimopoulos Georgios , Taoukis Petros , Topakas Evangelos 
Published: January 2023

Abstract
Alternative sweeteners, such as steviol glucosides from the plant Stevia rebaudiana Bertoni, are becoming increasingly popular for the design of next-generation foodstuffs. However, the bitter aftertaste of native steviol glucosides is one of the main reasons behind consumer reluctance towards stevia-containing products. Biocatalysis could be a sustainable solution to this problem, through addition of glucosyl moieties to the molecule. Glycoside hydrolases are enzymes performing transglycosylation reactions, and they can be exploited for such modifications. In the present work, the commercial β-glucanase Finizym 250L® was employed for the transglycosylation of stevioside. After optimization of several reaction parameters, the maximal reaction yield obtained was 19%, with barley β-glucan as the glycosyl donor. With the aim to develop a sustainable process, β-glucan extracts from different fungal sources were prepared. Pulsed Electric Field pretreatment of mycelial biomass resulted in extracts with higher β-glucan content. The extracts were tested as alternative glucosyl donors, reaching up to 15.5% conversion yield, from Pleurotus-extracted β-glucan. Overall, in the present work a novel enzymatic process for the modification of stevioside is proposed, with concomitant valorization of β-glucans extracted from fungal biomass, potentially generated as a byproduct from other applications, in concert with the principles of circular economy.

Graphical Abstract