bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostate stereotactic body radiotherapy: quantifying intra-fraction motion and calculating margins using the new BIR geometric uncertainties in daily online IGRT recommendations
Authors: McNeice Joseph M , Sanilkumar Nandu , Alexander Sophie E , Talbot James , Tree Alison C , McNair Helen A 
Published: March 2023

Objectives: To measure the magnitude of intra-fraction prostate motion (IFPM) during stereotactic radiotherapy (SBRT) delivered without intra-fraction tracking. To assess if current margins adequately cover IFPM. To derive margins using new guidelines. Methods: IFPM was determined in 20 patients receiving 36.25 Gy in 5 fractions using 97 pairs of pre- and post-treatment cone beam CT (CBCT) scans. Correlation of time between CBCT acquisitions and motion was determined. The magnitude of IFPM was compared to current margins (6 mm isotropic, 3 mm posterior). Margins were calculated using IFPM alone and updated guidelines. Results: The averaged 3D root mean square IFPM was 2.5 mm (4.2 mm). Independent prostate motion was predominantly posterior (70%) and inferior (63%). There was weak correlation between posterior (ρ = 0.38) and inferior (ρ = 0.36) IFPM and time. IFPM greater than current margins occurred in 8 of 97 fractions, six in the posterior direction. Margins were ≤3.5 mm using IFPM alone and ≤3.3 mm Left 3.5 mm Right, 7.0 mm inferior, 3.7 mm superior, 4.4 mm anterior and 3.3 mm posterior using new guidelines, compensating for motion in 92% of fractions. Conclusions: Our current SBRT margins account for 92% of IFPM, predominantly posterior and inferior. Although updated guidelines suggest an increase in margins inferiorly, any increase must be balanced against the possibility of increased toxicity, particularly if biochemical control and side-effects are favourable with current practice. Advances in knowledge: The difference between current clinical margins and those determined using updated guidance is demonstrated. The implications must be considered against clinical outcomes.
In vitro germination and regeneration of Senna artemisioides, a valuable leguminous ornamental shrub
Authors: BERTSOUKLIS Konstantinos , NAKSI Kostandin , ARETAKI Paraskevi-Evangelia 
Published: March 2023

Τhis research was carried out at the prospect of introducing new ornamental species in the floriculture industry concerning the use of valuable plants. A leguminous species native to Australia was the object of the present study. Seeds of Senna artemisioides established in a private botanical garden were chosen as the starting material for both germination and in vitro studies. Hot water treatment at 90 °C, for 10 min was applied to interrupt the seed-coat dormancy. Incubation was conducted in vitro in Petri dishes, at seven different temperatures ranging from of 5.0 to 35.0 °C, involving three separate treatments of incubation at 5.0 °C, for 0, 30 and 60 days. The seeds germinated at 25 °C (56.0%). Node explants derived from produced seedlings were cultured in vitro onto Murashige and Skoog media (MS), hormone free (Hf) or containing 6-Benzyladenine (BA). The establishment of initial cultures was successful being higher on MS supplemented with BA at the range 0.1-1.0 mg L-1 media. The multiplication phase followed on MS media containing the same range of a total of four cytokinins widely used in in vitro experimentation, i.e BA, Kinetin (KIN), N6-Isopentenyladenine (2IP) and Zeatin (ZEA). 1-Naphthaleneacetic acid (NAA) was tested in conjunction with the higher concentration of the four cytokinins. MS media supplemented with BA at 0.5 mg L-1 led to a satisfactory proliferation rate; 2.4 shoots/explant were formed. Rooting phase had moderate efficiency, being higher for media with 4.0 mg L-1 IBA. Acclimatisation was successful for all rooted plantlets, promising an effective method for exploitation of this new ornamental species of high value.
Qualitative analysis of mothers’ perception related to the delivery of information surrounding premature births
Authors: Randriamboarison Doriane , Fustec Elisa , Enderlé Isabelle , Yverneau Mathilde , Breton Karine Le , Lassel Linda , Orfanos Nadia Mazille , Pladys Patrick 
Published: March 2023

Abstract
Background: Prematurity is a major health issue due to its potential outcomes and socioeconomic impact. Prenatal counseling is of major importance for parents because it is believed that the risk of preterm birth is associated with a higher parental mental burden. Nowadays in France, the content and delivery of antenatal counseling is based on personal experience since there is a lack of official guidelines. The goal of the study was to evaluate maternal perception of antenatal information delivered in the setting of premature births.
Methods: A qualitative study was performed using semi-structured individual interviews of 15 mothers with a child born >26-34 GW. Data analysis was based on a constant comparative method.
Results: We found that concerning prenatal counselling content, parents wanted to be informed of their role in the care of their premature child more so than statistics that were not always considered relevant. Parents’ reactions to the announcement of the risk of a premature birth was dominated by stupefaction, uncertainty and anxiety. When it comes to the setting of prenatal counselling, patients’ room was deemed an appropriate setting by parents and ideally the presence of a coparent was appreciated as it increased patients’ understanding. The physicians’ behavior during the counselling was considered appropriate and described as empathic and optimistic. The importance of support throughout the hospitalization in the form of other parents’ experiences, healthcare professionals and the possibility to preemptively visit the NICU was emphasized by participants. Delivery experience was dominated by a sense of uncertainty, and urgency. Some leads for improvement included additional support of information such as virtual NICU visit; participants also insisted on continuity of care and the multidisciplinary aspect of counselling (obstetrician, pediatrician, midwive, nurse, lactation consultant and psychologist).
Conclusion: Overall general guidelines on prenatal counseling seem necessary, however personalization remains fundamental.
BABS on a mission: An experimental study on the effects of message framing and the use of a patient testimonial on intentions of osteoarthritis patients to adhere to treatment advice
Authors: Oomen J.M.H. , Ende C.H. van den , Schers H.J. , Koëter S. , Assendelft W.J.J. , Das E. 
Published: March 2023

Abstract
Background
Message framing, i.e., focusing on either gains or losses, is a commonly used technique in health communication to influence beliefs, and ultimately, health behaviors. The use of a patient testimonial in educational material might also strengthen effects.
Objectives
To study the effects of 1) message framing and 2) patient testimonials on osteoarthritis patients’ beliefs about and intentions to be physically active and to use pain medication.
Methods
. Members of a research panel (n = 639) with a self-reported diagnosis of knee OA were invited to participate and, if willing and consenting randomly allocated to watchi one out of four video messages combining a framing condition (gain or loss-frame) with the use of a testimonial (yes/no). After watching this video, participants completed a questionnaire on attitudes, behavioral beliefs, attitudes towards physical activity and pain medication (1 = completely disagree, 7 = completely agree), and intentions towards physical activity and pain medication (1 = I do not do this now and am not planning doing this, 7 = I am doing this already for more than 6 months). ANOVA was used to assess the main and interaction effects.
Results
A total of 154 respondents completed the questionnaire. Message framing and the use of a testimonial did not impact attitudes, beliefs, or intentions on physical activity. However, loss framing resulted in more positive attitudes towards pain medication (mean (SD) 5.5 (1.6)) than gain framing (mean (SD) 4.9 (1.9), mean difference = 0.6, 95% CI [0.0, 1.1]). Furthermore, the patient testimonial induced more positive pain medication attitudes (mean (SD) 6.0 (1.1)) than the informative control message (mean (SD) 5.0 (1.7), mean difference = 0.9, 95% CI [0.1, 1.6]) when the message used a loss, rather than a gain-frame.
Conclusion
This study showed that describing the disadvantages of nonadherence to pain medication resulted in more positive beliefs about pain medication than stating the advantages of adherence. The use of a patient testimonial within this loss-frame strengthened the effect. Our findings indicate that the use of framing and testimonials in OA care matters and that health care providers should be aware of the potential effects of emphasising either gains or losses in communicating with their patients.
Combining amide proton transfer-weighted and arterial spin labeling imaging to differentiate solitary brain metastases from glioblastomas
Authors: Chen Ling , Li Yao , Zhang Jinhuan , Li Shuanghong , Huang Lizhao , Tang Lifang , Wu Min , Zhu Li , Li Tao , Zeng Zisan 
Published: March 2023

Abstract
This study aimed to evaluate the clinical utility of amide proton transfer-weighted imaging (APTw) and arterial spin labeling (ASL) in differentiating solitary brain metastases (SBMs) from glioblastomas (GBMs). All patients underwent conventional MRI, APTw, and ASL scans on a 3.0 T MRI system. The mean APTw value and mean cerebral blood flow (CBF) value were measured. The differences in various parameters between GBMs and SBMs were assessed using the independent-samples t test. The quantitative performance of these MRI parameters in distinguishing between GBMs and SBMs was evaluated using receiver operating characteristic (ROC) curve analysis. Our results showed that GBMs exhibited significantly higher APTw and CBF values in peritumoral regions compared with SBMs (P<0.05). There was no significant difference between SBMs and GBMs in tumor cores. APTw MRI had a higher diagnostic efficiency in differentiating SBMs from GBMs (AUC: 0.864; 75.0% sensitivity and 81.8% specificity). Combined use of APTw and CBF value increased the AUC to 0.927. In conclusion, APTw may be superior to ASL for distinguishing between SBMs and GBMs. Combination of APTw and ASL showed better discrimination and a superior diagnostic performance.
Design and Parametric Analysis of Tungsten Disulfide ETL Based Perovskite Solar Cell
Authors: chaudhary srishtee , Mehra Rajesh , Raj Balwinder 
Published: March 2023

Abstract

The efficiency of Solar cells has been impacted by various factors. Being an abundant source by nature, research work is being carried upon regarding their performance parameters to a great extent. In this paper solar structure is optimized for better performance. The simulation of the proposed solar cell is carried on SCAPs software. The simulation work portraits the effect incorporating front and back contacts in the existing perovskite solar cell structure. The involvement of contact parameters in the structure resulted in efficiency improvement. Withal substituting the (Ca) metal as Back contact with work function of 2.9 eV and (Au) as front contact with work function 5.47 eV, the solar cell showed quantitative improvement from existing designs. In the study, existing perovskite solar cells with ETL Cd1- xZnxS(Cadmium zinc sulphide), perovskite layer MAPbI3- xClx, and HTL CuI(Copper Iodide) and CuSbS2 (Copper antimony sulfide) is compared in terms of efficiency. The proposed solar cell with Spiro-OMeTAD as HTL showed the highest PCE of 28.06%.
Design and Implementation of an Asymmetric Face Recognition System Based on Unsupervised Learning
Authors: Chang Chih-Yung , santra Arpita Samanta , Chang I-Hsiung , Wu Shih-Jung , Roy Diptendu Sinha , Zhang Qiaoyun 
Published: March 2023

Abstract
This paper mainly discusses the asymmetric face recognition problem where the number of names in a name list and the number of faces in the photo might not be equal, but each face should be automatically labeled with a name. The motivation for this issue is that there had been many meetings in the past. After each meeting, the participant took group photos. The meeting provided only a corresponding name list of participants without one-to-one labels. In the worst case, the group photo might mix with the faces that were not participating in the meeting. Another reason for asymmetric face recognition is that some meeting personnel did not appear in photos because they assisted in taking pictures. This paper proposes an Asymmetric Face Recognition Mechanism, called AFRM in short. Initially, the proposed AFRM adopts the Histogram of Oriented Gradients (HOG) and Support Vector Machine (SVM) to detect and extract all faces from photos. Next, AFRM extracts the features from each face using the convolution feature map (Conv_FF)and adopts the features to partition the faces into different classes. Then the AFRM applies the statistic-based mechanism to map each name in the name list to each face class. According to this mapping, each face will be associated with one name. To quickly identify a face during the meeting, the AFRM applies the K-Nearest Neighbors (KNN) to represent the features of each face. During the new meeting, the proposed AFRM can extract the feature of one face and then adopts KNN to derive the features. Experimental results show that the proposed mechanism achieves more than 97% accuracy without one-to-one name and face labeling.
Effect of Fixed-dose Combination Amlodipine/Valsartan in Comparison to
Two Drug Combination Nebivolol/Valsartan on 24-Hour Ambulatory
Blood Pressure
Authors: Hanna Selvia M. , Rabea Hoda M. , Abdelrahim Mohamed E.A. , Mahmoud Hesham B. 
Published: March 2023

Background:
Nebivolol has a dual mechanism of action, exerting a moderate b- block-ade effect and reducing peripheral arterial resistance, as a result, the antihypertensive effect of nebivolol may be higher than that of a potent vasodilator CCB such as amlodipine.

Aims:
The study evaluated the effect of two nebivolol/valsartan on 24 hour ambulatory blood pres-sure versus amlodipine/valsartan in grade II or III hypertension patients or having uncontrolled BP despite treatment. Ambulatory blood pressure monitoring is a powerful method to monitor the changes in blood pressure over the 24 hour.

Materials and Methods:
A total of 74 from 90 patients continued the study. Fourty patients re-ceived amlodipine 10 mg/valsartan 160 mg (group I), and thirty-four patients received nebivolol 5 mg/ valsartan 160 mg (group II). Peripheral blood pressure readings were measured at randomiza-tion at 6 and 12 weeks. Ambulatory blood pressure was measured at randomization and 12 weeks.

Results:
Both drug combinations showed high efficacy in reducing peripheral and 24 hour ambu-latory BP. There was no statistically significant difference between the groups in lowering periph-eral systolic and diastolic blood pressure at 6 and 12 weeks. Furthermore, both groups failed to show any significant difference in reducing 24 hour SBP and DBP. Regarding day SBP, the blood pressure dropped by -5.63 ± 14.87 in group I and -6.25 ± 11.59 in group II (p = 0.844). Also, group I reduced the day DBP average by -2.53 ± 9.83 and group II by -3.61 ± 9.78 (p = 0.640). In addition, both drug combinations had no statistically significant difference in lowering night SBP and DBP average.

Conclusion:
Both treatment groups reached the target ambulatory blood pressure, and there was
no statistically significant difference between both groups as a regard reduction in all ambulatory
blood pressure readings.
Detecting Ground Glass Opacity Features in Patients With Lung Cancer: Automated Extraction and Longitudinal Analysis via Deep Learning–Based Natural Language Processing
Authors: Lee Kyeryoung , Liu Zongzhi , Chandran Urmila , Kalsekar Iftekhar , Laxmanan Balaji , Higashi Mitchell K , Jun Tomi , Ma Meng , Li Minghao , Mai Yun , Gilman Christopher , Wang Tongyu , Ai Lei , Aggarwal Parag , Pan Qi , Oh William , Stolovitzky Gustavo , Schadt Eric , Wang Xiaoyan 
Published: March 2023

Background
Ground-glass opacities (GGOs) appearing in computed tomography (CT) scans may indicate potential lung malignancy. Proper management of GGOs based on their features can prevent the development of lung cancer. Electronic health records are rich sources of information on GGO nodules and their granular features, but most of the valuable information is embedded in unstructured clinical notes.

Objective
We aimed to develop, test, and validate a deep learning–based natural language processing (NLP) tool that automatically extracts GGO features to inform the longitudinal trajectory of GGO status from large-scale radiology notes.

Methods
We developed a bidirectional long short-term memory with a conditional random field–based deep-learning NLP pipeline to extract GGO and granular features of GGO retrospectively from radiology notes of 13,216 lung cancer patients. We evaluated the pipeline with quality assessments and analyzed cohort characterization of the distribution of nodule features longitudinally to assess changes in size and solidity over time.

Results
Our NLP pipeline built on the GGO ontology we developed achieved between 95% and 100% precision, 89% and 100% recall, and 92% and 100% F1-scores on different GGO features. We deployed this GGO NLP model to extract and structure comprehensive characteristics of GGOs from 29,496 radiology notes of 4521 lung cancer patients. Longitudinal analysis revealed that size increased in 16.8% (240/1424) of patients, decreased in 14.6% (208/1424), and remained unchanged in 68.5% (976/1424) in their last note compared to the first note. Among 1127 patients who had longitudinal radiology notes of GGO status, 815 (72.3%) were reported to have stable status, and 259 (23%) had increased/progressed status in the subsequent notes.

Conclusions
Our deep learning–based NLP pipeline can automatically extract granular GGO features at scale from electronic health records when this information is documented in radiology notes and help inform the natural history of GGO. This will open the way for a new paradigm in lung cancer prevention and early detection.
Case of malignant brain edema despite successful recanalization after mechanical thrombectomy for anterior circulation stroke
Authors: Suroto Nur Setiawan , Fauzi Asra Al , Christi Ayu Yoniko , Simanjuntak Kevin Ariel Tiopan , Budiono Perthdyatama Syifaq 
Published: March 2023

Background:
Therapeutic reperfusion with endovascular treatment (EVT) for acute ischemic stroke is typically associated with better long-term functional outcome compared to standard medical care. However, post-procedural brain edema remained present in around half of EVT patients. Malignant brain edema (MBE) is a serious condition that can lead to increased intracranial pressure, rapid neurologic deterioration, and cerebral herniation, neutralizing the favorable efficacy of EVT on functional outcomes.

Case Description:
A 51-year-old man with a history of atrial fibrillation presented with acute onset of hemiplegia and severe bradyarrhythmia. A head computed tomography-scan demonstrated hyperdense middle cerebral artery (MCA) sign. Intravenous thrombolysis was administered before temporary pacemaker insertion. The digital subtraction angiography confirmed occlusion of the M1 branch of the right MCA with no collaterals in the territory of the occluded vessel. Mechanical thrombectomy (MT) was performed 6 h after onset and successfully achieved modified thrombolysis in cerebral infarction 3 revascularization in 6 h 20 min. The patient later experienced massive brain edema that required emergent decompressive craniectomy. The modified Rankin scale score was 4 in 1- and 3-month’s follow-up.

Conclusion:
MBE after MT results in unsatisfactory functional outcomes, even if it has successful revascularization. No collateral in the territory of the occluded vessel in the initial angiogram is one of the predictors of MBE after MT.
Your Finger, your Tiger: Netiquette Violations of the Microcelebrity Parody Content on Social Media
Authors: Astuti Yanti Dwi , Zamroni Mohammad 
Published: March 2023

Netiquette is still lacking among Indonesian netizens. One of the netiquette violations was carried out by micro-celebrities Tri Suaka and Zinidin Zidan, who virally recorded and distributed mocking parody videos of Andika Kangen Band. This research aims to uncover the phenomenon of the practice of violating netiquette by microcelebrities using the constructivism paradigm with qualitative content analysis methods in order to draw a conclusion from the meaning of a text in the video. The audience here plays two roles at once, namely consumers and producers. The theories used are of Digital Literacy, Social Media and Netiquette. The results of the study reveal that internet ethics violations occur due to the anonymous and confidential nature of digital media resulting in no recognition of identity, misinterpretation of digital rights related to unlimited freedom of expression, and excessive use of social media time by netizens. Research has also found that netizens more easily show attitudes and opinions that are usually hidden from others due to social and economic conditions that make them anxious and frustrated, consumption of and belief in hoaxes, low awareness of ethics and morality, and lack of understanding about sanctions for ethical violations related to digital media.
Brain Amyloid in Sporadic Young Onset Alzheimer’s Disease
Authors: Panegyres Peter K. , Robins Peter 
Published: March 2023

Background: Controversy exists as to the role of the amyloid-β (Aβ) peptide in the pathophysiology of Alzheimer’s disease (AD). Objective: To clarify the effect of age on Aβ deposition in sporadic AD by exploring the degree of amyloid burden in patients with sporadic young onset AD (YOAD). Methods: Patients were diagnosed with YOAD with dementia starting before the age of 65 years (N = 42; males = 20, females = 22). A cross-sectional analysis of amyloid binding using positron emission tomography (PET) imaging was performed using the C-Pittsburgh Compound B (PiB). The global standardized uptake value ratios (gSUVR) were examined using the Wilcoxon two-sample test, as were the cognitive scores between disease and healthy control populations. Differences in PiB retention in different anatomical areas were compared using the Kruskal-Wallis test. The contrast in APOE genotyping between groups was calculated with Fisher’s Exact Test. Results: Women had a median gSUVR = 2.68±0.73 and 73% had at least one APOE ɛ4 allele. Men had gSUVR = 2.37±0.54, with 80% having at least one APOE ɛ4 allele. The gSUVRs were significantly higher than the control populations for men and women and had significantly greater frequency of APOE ɛ4. Men and women analyzed together had significantly greater amyloid burden and APOE ɛ4 allele frequencies than controls, but no differences existed between them in gSUVR nor in the anatomical distribution of amyloid uptake. Conclusion: Men and women with YOAD have greater amyloid uptake than controls and have more APOE ɛ4 alleles. Our findings suggest that the Aβ peptide is operational in young onset dementia and driven by the APOE ɛ4 allele.