bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contextual-Aware and Expert Data Resources for Brazilian Portuguese Hate Speech Detection
Authors: Vargas Francielle , Carvalho Isabelle , Pardo Thiago A. S. , Benevenuto Fabrício 
Published: April 2023

Abstract
This paper provides data resources for low-resource hate speech detection. Specifically, we introduce a large-scale expert annotated corpus of Brazilian Instagram comments and a context-aware offensive lexicon, which was manually extracted by a linguist from the proposed corpus and annotated with contextual information. We further provide native-speaker translations and adaptations from the specialized lexicon for other low-resource languages. The corpus consists of 7,000 document-level multi-layer annotations: (i) a binary offensive class, (ii) offensiveness-level classes, and (iii) nine hate speech targets. The context-aware offensive lexicon holds 1,000 explicit and implicit terms and expressions with pejorative connotations annotated with context-dependent offensiveness and context-independent offensiveness labels. Both corpus and lexicon were annotated by three different experts and achieved high inter-annotator agreement. Finally, we implemented baseline experiments on both data resources (corpus and lexicon). Results show the reliability of the proposed data, outperforming baseline dataset results in Portuguese, as well as presenting promising results for hate speech detection in different languages.
Use of Airfoils for Enhancement of Photosynthesis Rate of Microalgae in Raceway
Authors: Inostroza Cristian , Dávila Javier , Román Sergio , Fernández-Sevilla José M. , Acién F. Gabriel 
Published: April 2023

Abstract
The lack of adequate vertical mixing is one of the factors limiting the productivity of open raceway microalgae reactors. The existence of large gradients of light involves the cells being mainly adapted to local irradiance instead of average irradiance, which would allow for maximizing the light utilization efficiency, thus maximizing the biomass productivity of microalgae cultures. To overpass this problem different alternatives have been proposed, one of the more suitable being the utilization of airfoils to improve vertical mixing. In this work, numerical and experimental studies were performed to analyse the effect of the aerodynamic airfoils patented by the University of Seville (WO2020120818A1). The goal is to improve the photosynthetic efficiency, but also a better understanding of the light regime to which the microalgae cells are exposed in these systems and how to improve it. Computational Fluid Dynamics (CFD) was used to optimize the flow generated by the airfoils. A dynamic photosynthesis model (Rubio Camacho et al., 2003) was used to estimate the photosynthesis rate as a function of the light regime to which the cells are exposed, including photo-adaptation and photo-inhibition phenomena. The results confirm that the use of airfoils improves the vertical mixing and the photosynthesis rate, with a negligible increase in energy consumption. The photosynthetic benefits were observed 10 m downstream of the airfoils, resulting in an increase in photosynthesis rate and productivity by up to 30%. These results confirm the benefits of an increase in mixing in microalgae cultures, especially when focusing on the movement of the cells between the different illuminated zones while maintaining low energy consumption and CAPEX.
Pruritus Related to Trastuzumab and Pertuzumab in HER2+ Breast Cancer Patients
Authors: Gu Stephanie , Dusza Stephen , Quigley Elizabeth , Haliasos Helen , Markova Alina , Marchetti Michael , Moy Andrea , Dang Chau , Modi Shanu , Lake Diana , Noor Sarah , Lacouture Mario 
Published: April 2023

Abstract
Purpose
The combination of trastuzumab and pertuzumab (HP) as part of a taxane-based regimen has shown benefit in the adjuvant and metastatic HER2+ breast cancer setting. In the CLEOPATRA trial, pruritus was reported in 11-17.6% of patients. The clinical phenotype and potential treatment strategies for this event have not been reported.
Methods
A retrospective review of 2583 patients receiving trastuzumab and pertuzumab for the treatment of HER2+ breast cancer from 11/23/2011 to 6/21/2021 was performed at Memorial Sloan Kettering Cancer Center (MSKCC). Patient demographics, pruritus characteristics, and treatments as documented in the electronic medical record (EMR) were included in this analysis.
Results
Of 2583 pts treated with HP, 122 (4.72%) with pruritus were identified. On average, patients experienced pruritus 319.0 days (8-3171) after initiation of HP. The upper extremities (67.4%), back (29.3%), lower extremities (17.4%), and shoulders (14.1%) were the most commonly affected regions. Grade 1/2 pruritus (97.6%) occurred in most cases. Patients responded primarily to treatment with topical steroids (52.2%), antihistamines (29.9%), emollients (20.9%), and gabapentinoids (16.4%). Of those with pruritus, 4 patients (3.3%) required treatment interruption or discontinuation.
Conclusions
Pruritus is uncommon in patients on trastuzumab and pertuzumab, generally a chronic condition, with gabapentinoids or antihistamines representing effective therapies.
SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice
Authors: Love J. , Rodriguez-Aponte Sergio , Tostanoski Lisa , Dalvie Neil , Johnston Ryan , Jacob-Dolan Catherine , Powers Olivia , Hachmann Nicole , Miller Jessica , Hall Kevin , Siamatu Mazuba , Mazurek Camille , Surve Nehalee , Barouch Dan 
Published: April 2023

Abstract
We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. After two and three doses, a RBD dimer and trimer elicited antibody levels in mice comparable to an RBD-VLP. Furthermore, an Omicron (BA.1) RBD hetero-dimer induced neutralizing activity similar to the RBD-VLP. A RBD hetero-dimer and RBD-VLP also shows comparable breadth to other SARS-CoV-2 variants-of-concern (VOCs).
A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers
Authors: Huang Hao , Qiu Duoliang , Zhou Zhengyang , Wu Biaobiao , Shao Lening , Pu Yuwei , He Tengfei , Wu Yongyou , Cui Dawei , Zhong Fengyun 
Published: April 2023

Abstract
Background Human health and life are threatened by cancer with high morbidity and mortality worldwide. In many experiments, CDKN1B level is associated with cancer risk, Nevertheless, no pan-cancer analysis has been conducted on CDKN1B in human cancers.Methods With the help of bioinformatics, a pan-cancer analysis was conducted on the expression levels of CDKN1B in cancer tissues and adjacent tissues from the TCGA, CPTAC and GEO databases. The CDKN1B expression levels in tumor patients was further validated using immunohistochemistry (IHC) and quantitative real-time PCR.Results In the study, we first investigated the cancer-related roles of CDKN1B's in 40 tumors with malignancy. The CDKN1B gene encodes the p27Kip1 protein, which can block the production cyclin-dependent kinase (CDK), which is obviously related to the function and survival of cancer cells and alters the prognosis of cancer patients. Furthermore, CDKN1B function requires both protein processing and RNA metabolism. Additionally, the elevated expression of the CDKN1B gene and protein was validated in several cancer tissues from the patients.Conclusions These results showed that the levels of CDKN1B were considerably different in a number of cancer tissues, offering a potential future target for cancer therapy.
Visual design of art based on interactive technology and environment aware intelligent devices
Authors: Li Jingyao 
Published: April 2023

Abstract
In the digital era, visual programming technology has brought fresh blood to the field of art creation, making it completely realize the structural transformation, thus promoting art design to get rid of the limitations of traditional media. Based on the integration of environment awareness technology and interactive technology, this paper realizes the design and improvement of art interactive creation visualization system. The environmental awareness technologies included in the system are divided into several types with different application effects, including data storage and collection technology, data processing technology and scenario management technology. The system itself is designed as a three-tier system, including application layer, foundation layer and user interaction layer. By using environment awareness technology, the system realizes the collection and source analysis of target data, and can perform scenario state calculation, information reasoning and storage. By introducing visualization technology, the system is equipped with a visual programming model, which can realize programming processing based on node data. It can be seen from the simulation experiment data that the system can achieve efficient and feasible data processing, and its memory utilization, CPU utilization and requests, bandwidth and other indicators are positively correlated. Therefore, the application of this visualization system can effectively assist individual artists in artistic creation, break communication barriers, achieve information interaction, bring new possibilities for artistic creation, and effectively adapt to the future art development environment. In this paper, the visual system is designed by applying environment awareness and interactive technology to the field of art design.
Ludwig’s Angina with facial nerve palsy, a rare presentation
Authors: Bogale Manendante , Alemayehu Dawit , Deresse Tilahun , Assefa Wubshet , Dessalegn Megbar 
Published: April 2023

Abstract
Ludwig's angina is an inflammation of neck spaces making it immediately life-threatening. The infection spreads to adjacent planes destructing facial planes, aspirations of infective particles, or septic embolism to distant areas. This is about a 40 years-old man who presented with painful anterior neck swelling of 7 days duration. A diagnosis of Ludwig’s angina with unilateral facial nerve paralysis and treated with immediate incision and drainage. Although facial nerve palsy associated with Ludwig’s angina is rare, it improves with immediate surgical decompression.
Accuracy and efficiency of two control strategies in commanding a robotic laparoscope holder by foot: An experimental study on surgeons' use pattern
Authors: Yang Yan-Jun , Vadivelu Arvind , Hepworth Jessica , Zeng Yongpeng , Pilgrim Charles , Kulic Dana , Abdi Elahe 
Published: April 2023

Abstract
The implementation of a laparoscope-holding robot in minimally invasive surgery enhances the efficiency and safety of the operation. However, the extra robot control task can increase the cognitive load on surgeons. A suitable interface may simplify the control task and reduce the surgeon load. Foot interfaces are commonly used for commanding laparoscope-holding robots, with two control strategies available: decoupled control permits only one Cartesian axis actuation, known as decoupled commands; hybrid control allows for both decoupled commands and multiple axes actuation, known as coupled commands. This paper aims to determine the optimal control strategy for foot interfaces by investigating two common assumptions in the literature: 1. Decoupled control is believed to result in better predictability of the final laparoscopic view orientation, and 2. Hybrid control has the efficiency advantage in laparoscope control. Our user study with 11 experienced and trainee surgeons shows that decoupled control has better predictability than hybrid control, while both approaches are equally efficient. In addition, using two surgery-like tasks in a simulator, users' choice of decoupled and coupled commands is analysed based on their level of surgical experience and the nature of the movement. Results show that trainee surgeons tend to issue more commands than the more experienced participants. Single decoupled commands were frequently used in small view adjustments, while a mixture of coupled and decoupled commands was preferred in larger view adjustments. A guideline for foot interface control strategy selection is provided.
Association between Dietary Vitamin E Intake and Cognitive Decline Among old American: National Health and Nutrition Examination Survey
Authors: Zhang kai , Han Yu , Gu Zhaoxuan , Hou Zhengyan , Yu Xiaoqi , Gao Min , Cai Tianyi , Gao Yafang , Xie Jinyu , Gu Fangming , Chen Jianguo , Chen Bowen , Liu Tianzhou 
Published: April 2023

Abstract
Purpose: Numerous studies have reported that vitamin E plays a key role in nervous system development and neurotransmitter production.This study aimed to investigate changes in vitamin E intake in older adults with low cognitive performance using NHANES.
Methods: In this cross-sectional study, we examined a sample of 2,255 American adults aged 60 and over between 2011 and 2014. We collected dietary data by averaging two recalls for dietary use to determine vitamin E intake. We assessed cognitive function using five tests and analyzed the association between these variables using a multivariate logistic regression model.
Results: A total of 2255 participants aged ≥60 years from the National Health and Nutrition Examination Survey (NHANES) for the 2011-2014 cycle were included in the analysis. Vitamin E intake was negatively associated with cognitive function. In the Z-test, each 1 mg/day increase in dietary intake of vitamin E was associated with a 6% lower likelihood of severe cognitive performance in the fully fitted model (OR = 0.94, 95% CI: 0.91~0.97) The results did not change when exposure was analyzed as a categorical variable. Compared with Q1, Q4 reduced the risk of cognitive impairment by 53% in the z-test (OR = 0.47, 95% CI: 0.33~0.67).No significant statistical interaction between the variables was found
Conclusions: An increased dietary intake of vitamin E has been associated with decreased cognitive impairment in individuals over 60 years old. The dose-response curve showed an L-shaped association between dietary vitamin E intake and cognitive decline in US adults, with an inflection point of approximately 9.296 mg/day.
On-chip phonon-magnon reservoir for neuromorphic computing
Authors: Scherbakov Alexey , Yaremkevich Dmytro , De Clerk Luke , Kukhtaruk Serhii , Campion Richard , Rushforth Andrew , Savel’ev Sergey , Balanov Alexander , Bayer Manfred , Nadzeyka Achim 
Published: April 2023

Abstract
Reservoir computing is a concept in which signals to process are mapped onto a high-dimensional phase space of a fixed dynamical system called “reservoir” for subsequent recognition by an artificial neural network. Implementations of reservoirs are possible using different hardware and, accordingly, exploit different carriers and mechanisms of signal transformation. Despite the growing number of neuromorphic prototypes of reservoirs, demands for miniaturization, efficiency, and robustness all require implementation of the reservoir on a chip, and remain among the key challenges. Here we propose a nanodevice, in which a sandwich of a semiconductor phonon waveguide and a patterned ferromagnetic layer enables efficient reservoir computing. The optical input signal is coded by a pulsed write-laser and converted into a propagating multimode phonon wave packet, which interacts with a bunch of magnon modes. The output signal read by a second laser represents a phase-sensitive superposition of all the phonon and magnon modes, which possesses ultimate sensitivity to the relative positions of the write- and read-laser spots. The reservoir efficiently separates the visual shapes drawn by the write-laser beam on the nanodevice surface in an area with size comparable to a single pixel of a modern digital camera. Thus, our finding suggests the phonon-magnon interaction as a promising hardware basis for realization of rapid on-chip reservoir computing for future neuromorphic architectures.
Transmission of Alzheimer's Disease-Associated Microbiota Dysbiosis and its Impact on Cognitive Function: Evidence from Mouse Models and Human Patients
Authors: Zhang Yiying , Shen Yuan , Liufu Ning , Liu Ling , li wei , Shi Zhongyong , Zheng Hailin , Mei Xinchun , Chen Chih-Yu , Jiang Zengliang , Abtahi Shabnamsadat , Dong Yuanlin , Liang Feng , Shi Yujiang , Cheng Leo , Yang Guang , Kang Jing X. , Wilkinson Jeremy , Xie Zhongcong 
Published: April 2023

Abstract
Spouses of Alzheimer’s disease (AD) patients are at higher risk of developing AD dementia, but the reasons and underlying mechanism are unknown. One potential factor is gut microbiota dysbiosis, which has been associated with AD. However, it remains unclear whether the gut microbiota dysbiosis can be transmitted to non-AD individuals and contribute to the development of AD pathogenesis and cognitive impairment. The present study found that co-housing wild-type mice with AD transgenic mice or giving them AD transgenic mice feces caused AD-associated gut microbiota dysbiosis, Tau phosphorylation, and cognitive impairment. Gavage with Lactobacillus and Bifidobacterium restored these changes. The oral and gut microbiota of AD patient partners resembled that of AD patients but differed from healthy controls, indicating the transmission of oral and gut microbiota and its impact on cognitive function. The underlying mechanism of these findings includes that the butyric acid-mediated acetylation of GSK3β at lysine 15 regulated its phosphorylation at serine 9, consequently impacting Tau phosphorylation. These results provide insight into a potential link between gut microbiota dysbiosis and AD and underscore the need for further research in this area.
Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib
Authors: Wang Dandan , Wei Yimei , Xu Lulu , Zhang Jie 
Published: April 2023

Abstract
Background and objective: Systemic sclerosis (SSc) is an immune-mediated rheumatic disease characterized by fibrosis and vascular lesions. Interstitial lung disease (ILD) is an early complication of SSc and the main cause of death from SSc. Although baricitinib shows good efficacy in a variety of connective tissue diseases, its role in systemic sclerosis-related interstitial lung disease (SSc-ILD) is unclear. The objectiveof our study was to explore the effect and mechanism of baricitinib in SSc-ILD.
Methods: We explored crosstalk between the JAK2 and TGF-β1 pathways. In vivo experiments, SSc-ILD mice model were constructed by subcutaneous injection of PBS or bleomycin (7.5 mg/kg) and intragastric administration of 0.5% CMC-Na or baricitinib (5 mg/kg) once every two days. We used ELISA, qRT‒PCR, western blotand immunofluorescence staining to evaluate the degree of fibrosis. In vitro experiments, we used TGF-β1 and baricitinib to stimulate human fetal lung fibroblasts (HFLs) and assessed protein expression by western blot.
Results: The vivo experiments showed that baricitinib notably alleviated skin and lung fibrosis, decreased the concentration of pro-inflammatory factors and increased those of the anti-inflammatory factors. Baricitinib affected the expression of TGF-β1 and TβRI/II inhibitiing JAK2. In the vitro experiments, following the culture of HFLs with baricitinib or a STAT3 inhibitor for 48 h, the expression levels of TβRI/II decreased. Conversely, with successful inhibition of TGF-β receptors in HFLs, JAK2 protein expression decreased.
Conclusions: Baricitinib attenuated bleomycin-induced skin and lung fibrosis in SSc-ILD micemodel by targeting JAK2 and regulating of the crosstalk between the JAK2 and TGF-β1 signaling pathways.
Evolution of Wolbachia reproductive and nutritional mutualism: insight from two novel strains that double infect pollinator of dioecious Ficus hirta
Authors: Liu Wanzhen , Xia Xue , Ding Yamei , Fang Ji-Chao , Yu Hui 
Published: April 2023

Abstract
Wolbachia is a genus of endosymbiont which can manipulate the reproductive system of hosts and exert an influence on metabolic processes. Wolbachia is dominant in male syconium of dioecious Ficus hirta with pollinator Valisia javana. From high-quality chromosome-level V. javana genome with PacBio long-read and Illumina short read sequencing, we discovered a sizeable proportion of Wolbachiasequences and then assembled two novel strains belonging to supergroup A. Besides the basic genome description, we identified mobile genetic elements including prophages and insertion sequences, genes related to biotin synthesis and metabolism, and cytoplasmic incompatibility related cif genes in them. The results showed that (i) A total of two prophages and 201 insertion sequences were found. The prophage WOjav1 is cryptic and WOjav2 relatively intact. IS5 is dominant family. (ii) At least three pairs of cif genes belong to type I and is speculated to cause strong CI with infected female biased reproductive advantages; (iii) The Wolbachiaonly provide biotin precursors to absorb and metabolize biotin which is synthesized by host plant. This research provided a basis for reproductive and nutritional mutualism between Wolbachiaand fig-fig wasp system, and will serve as a useful resource for further research into Wolbachia-pollinator-host interactions.
Predicting Tumor Repopulation through the Gene Panel Derived from Radiation Resistant Colorectal Cancer Cells
Authors: Song Yanwei , Deng Zheng , Sun Haoran , Zhao Yucui , Zhao Ruyi , Cheng Jin , Huang Qian 
Published: April 2023

Abstract
Background Tumor cells with the capability of radiation resistance can escape the fate of cell death after radiotherapy, serving as the main cause of treatment failure. Repopulation of tumors after radiotherapy is dominated by this group of residual cells, which greatly reduce the sensitivity of recurrent tumors to the therapy, resulting in poor clinical outcomes. Therefore, revealing the mechanism of radiation resistant cells participating in tumor repopulation is of vital importance for cancer patients to obtain a better prognosis.
Methods Co-expressed genes were searched by using genetic data of radiation resistant cells (from GEO database) and TCGA colorectal cancer. Univariate and multivariate Cox regression analysis were performed to define the most significant co-expressed genes for establishing prognostic indicator. Logistic analysis, WGCNA analysis, and other types of tumors were included to verify the predictive ability of the indicator. RT-qPCR was carried out to test expression level of key genes in colorectal cancer cell lines. Colongenic assay was utilized to test the radio-sensitivity and repopulation ability of key gene knockdown cells.
Results Prognostic indicator based on TCGA colorectal cancer patients containing four key radiation resistance genes (LGR5, KCNN4, TNS4, CENPH) was established. The indicator was shown to be significantly correlated with the prognosis of colon cancer patients undergoing radiotherapy, and also had an acceptable predictive effect in the other types of cancer. RT-qPCR shows that expression of level key genes was basically consistent with the radiation resistance level of colorectal cancer cells. The clonogenic ability of all key gene knockdown cells decreased after radiation treatment compared with the control groups.
Conclusions Our data suggest that LGR5, KCNN4, TNS4 and CENPH are correlated with radiation sensitivity of colorectal cancer cells, and the indicator composed by them can reflect the prognosis of colorectal cancer patients undergoing radiation therapy. Our data provide an evidence of radiation resistant tumor cells involved in tumor repopulation, and give patients undergoing radiotherapy an approving prognostic indicator with regard to tumor progression.