bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Zinc in Bone Tissue Health and Regeneration—a Review
Authors: Molenda Magda , Kolmas Joanna 
Published: April 2023

AbstractZinc is a micronutrient of key importance for human health. An increasing number of studies indicate that zinc plays a significant role in bone tissue’s normal development and maintaining homeostasis. Zinc is not only a component of bone tissue but is also involved in the synthesis of the collagen matrix, mineralization, and bone turnover. It has been demonstrated that zinc can stimulate runt-related transcription factor 2 (Runx2) and promote the differentiation of osteoblasts. On the other hand, zinc has been found to inhibit osteoclast-like cell formation and to decrease bone resorption by stimulating osteoclasts’ apoptosis. Moreover, zinc regulates the RANKL/RANK/OPG pathway, thereby facilitating bone remodeling. To date, not all mechanisms of Zn activity on bone tissue are well understood and documented. The review aimed to present the current state of research on the role of zinc in bone tissue, its beneficial properties, and its effects on bone regeneration. Since calcium phosphates as bone substitute materials are increasingly enriched in zinc ions, the paper included an overview of research on the potential role of such materials in bone filling and regeneration.
Holding Out
Authors: Cowan Tony 
Published: March 2023

This is a ground-breaking study of German operational command during a critical phase of the First World War from November 1916 to the eve of the third battle of Ypres. The situation faced by the German army on the Western Front in 1917 was very different from the one anticipated in pre-war doctrine and Holding Out examines how German commanders and staff officers adapted. Tony Cowan analyses key command tasks to get under the skin of the army's command culture, internal politics and battle management systems from co-ordinating the troops, matériel and different levels of command needed to fight a modern battle to continuously learning and applying lessons from the ever-changing Western Front. His detailed analysis of the German defeat of the 1917 Entente spring offensive sheds new light on how the army and Germany were able to hold out so long during the war against increasing odds.
Remdesivir use and antimicrobial stewardship restrictions during the coronavirus disease 2019 (COVID-19) pandemic in the United States: A cross-sectional survey
Authors: Mena Lora Alfredo J. , Burgos Rodrigo , Borgetti Scott , Chaisson Lelia H. , Bleasdale Susan C. 
Published: March 2023

Abstract
Deploying therapeutics for coronavirus disease 2019 (COVID-19) has proved challenging due to evolving evidence, supply shortages, and conflicting guideline recommendations. We conducted a survey on remdesivir use and the role of stewardship. Use differs significantly from guidelines. Hospitals with remdesivir restrictions were more guideline concordant. Formulary restrictions can be important for pandemic response.
Pore-engineered nanoarchitectonics for cancer therapy
Authors: Sutrisno Linawati , Ariga Katsuhiko 
Published: March 2023

AbstractNanoarchitectonics describes the integration of nanotechnology with other fields as a postnanotechnology concept that elevates it to material science. Based on this fundamental principle, we address pore-engineered nanoarchitectonics with application targets for cancer therapy by combining basic descriptions and exemplifying therapy applications in this review. The initial two sections briefly summarize pore-engineered nanoarchitectonics basics according to classification based on (i) material porosity and (ii) material composition. Afterward, the main application-oriented section—designing mesoporous material for cancer therapy—is presented. Various types of drug delivery systems, including mesoporous nanoparticles as nanocarriers, endogenous stimuli-responsive drug delivery, exogenous stimuli-responsive drug delivery, and targeted drug delivery, are described. Importantly, the clinical translation of mesoporous materials is further discussed. Mesoporous materials are unique nanoparticles that offer a network of cavities as vehicles for drug nanocarriers. Regarding the developments that allow mesoporous nanoparticles to be broadly used in clinical settings, there are several challenges that should be solved for their clinical application. From a clinical perspective, there are tremendous processes in the development of mesoporous materials.
In den Körper lächeln
Authors: Saldow Reinhold 
Published: March 2023

SummaryDurch Hypnose induzierte Trance zählt zu den ältesten Therapie-methoden und kann über den inneren Dialog mit Organen Körperfunktionen verbessern und emotionale Konflikte lösen. Besonders das Herz steht als Sitz von Liebe und Freude und zugleich Ort der Wut, Enge, Schmerzen und Härte in einem engen Zusammenhang mit der Emotionalität. Durch Hineinspüren, -atmen und -lächeln in Organe lassen sich „eingeklemmte“ Affekte und belastende Empfindungen entdecken, lösen und „ausatmen“ – sowohl in der Arbeit mit Klienten als auch im Rahmen der Eigenarbeit.
Neue Kraft schöpfen
Authors: Stumpf Ursula 
Published: March 2023

SummaryBei andauerndem Stress oder nach einer Erkrankung fühlen wir uns häufig wie „ausgebrannt“. Es fehlt die Kraft, den Herausforderungen des Alltags zu begegnen. Dann können Heilpflanzen helfen, die für ihre stärkende Wirkung auf Körper und Geist bekannt sind. Zu diesen sogenannten Tonika gehören unter anderem Braunelle, Odermennig, Tausendgüldenkraut, Löwenzahn und Weißdorn.
Clinical Course May Be Independent from Neuroimaging in DEPDC-5-Related Epilepsy
Authors: Bartolini Emanuele , Della Vecchia Stefania , Biagioni Tommaso , Montanaro Domenico , Ferrari Anna Rita 
Published: April 2023

Abstract
DEPDC5 is an upstream repressor of the mechanistic target of rapamycin pathway via the GATOR-1 complex. Pathogenic variants causing loss of function typically result in familial focal epilepsy with variable foci. Neuroimaging may either be normal or show brain malformations. Lesional and nonlesional cases may be present within the same family. Here, we describe a parent–child dyad affected by a truncating DEPDC5 pathogenic variant (c.727C > T; p.Arg243*), analyze the epilepsy clinical course, and describe neuroimaging characteristics from a 3T brain magnetic resonance imaging. Despite sharing the same variant, patients diverged both in terms of epilepsy severity and neuroimaging features. Surprisingly, the mother is still suffering from drug-resistant seizures and has normal neuroimaging, while the child has been experiencing prolonged seizure freedom notwithstanding a bottom-of-sulcus focal cortical dysplasia. An increasing gradient of severity has been proposed for families with GATOR1-related epilepsies. We confirm clinical and neuroradiological expressivities are variable and also suggest the prognostication of epilepsy outcome may be particularly difficult. The epilepsy outcome could partially be independent from brain structural abnormalities.
Time periods ranking according to the degree of the water source pollution
Authors: Yalaletdinova A V , Malkova M A , Vozhdaeva Y S , Kantor E A 
Published: March 2023

Abstract
The quality of river water was assessed by identifying time periods for which the values of turbidity, chromaticity, oxidizability and total hardness are maximum or minimum. Periods with high values of indicators were identified for which strict quality control of water purification is required: from January to April for total hardness and from April to July for turbidity, chromaticity and oxidizability. It was revealed that the largest deviations from the standard values in terms of indicators with their total impact on water pollution fall on the period from April to July, and the most unfavorable month is May. It has been established that the priority pollutant for the studied sections is water turbidity.
Improved insights into the SABIO-RK database via visualization
Authors: Dudaš Dorotea , Wittig Ulrike , Rey Maja , Weidemann Andreas , Müller Wolfgang 
Published: April 2023

AbstractSABIO-RK is a database for biochemical reactions and their kinetics. Data in SABIO-RK are inherently multidimensional and complex. The complex relationships between the data are often difficult to follow or even not represented when using standard tabular views. With an increasing number of data points the mismatch between tables and insights becomes more obvious, and getting an overview of the data becomes harder. Such complex data benefit from being presented using specially adapted visual tools. Visualization is a natural and user-friendly way to quickly get an overview of the data and to detect clusters and outliers. Here, we describe the implementation of a variety of visualization concepts into a common interface within the SABIO-RK biochemical reaction kinetics database. For that purpose, we use a heat map, parallel coordinates and scatter plots to allow the interactive visual exploration of general entry-based information of biochemical reactions and specific kinetic parameter values.Database URL https://sabiork.h-its.org/
Exploiting SMART pass filter deactivation detection to minimize inappropriate subcutaneous implantable cardioverter defibrillator therapies: a real-world single-centre experience and management guide
Authors: Monkhouse Christopher , Wharmby Amy , Carter Zoe , Hunter Ross , Dhinoja Mehul , Chow Anthony , Creta Antonio , Honarbakhsh Shohreh , Ahsan Syed , Orini Michele , Lambiase Pier D 
Published: April 2023

Abstract

Aims
The SMART Pass™ (SP) algorithm is a high-pass filter that aims to reduce inappropriate therapy (IT) in subcutaneous internal cardiac defibrillator (S-ICD), but SP can deactivate due to low amplitude sensed R waves or asystole. The association between IT and SP deactivation and management strategies were evaluated, hypothesizing SP deactivation increases the risk of IT and device re-programming, or lead/generator re-positioning could reduce this risk.

Methods and results
Retrospective single-centre audit of Emblem™ S-ICD devices implanted 2016 to 2020 utilizing health records and remote monitoring data. Cox regression models evaluated associations between SP deactivation and IT. A total of 348 patients (27 ± 16.6 months follow-up) were studied: 73% primary prevention. Thirty-eight patients (11.8%) received 83 shocks with 27 patients (7.8%) receiving a total of 44 IT. Causes of IT were oversensing (98%) and aberrantly conducted atrial fibrillation (2%). SP deactivation occurred in 32 of 348 patients (9%) and was significantly associated with increased risk of IT (hazard ratio 5.36, 95% CI 2.37-12.13). SP deactivation was due to low amplitude R waves (94%), associated with a higher defibrillation threshold at implant and presence of arrhythmogenic right ventricular cardiomyopathy. No further IT occurred 16 ± 15.5 months after corrective interventions, with changing the sensing vector being successful in 59% of cases.

Conclusion
To reduce the risk of IT, the cause of the SP deactivation should be investigated, and appropriate reprogramming, device, or lead modifications made. Utilizing the alert for SP deactivation and electrograms could pro-actively prevent IT.
Acquisition of host-derived carbon in biomass of the ectomycorrhizal fungus Pisolithus microcarpus is correlated to fungal carbon demand and plant defences
Authors: Stuart Emiko K , Singan Vasanth , Amirebrahimi Mojgan , Na Hyunsoo , Ng Vivian , Grigoriev Igor V , Martin Francis , Anderson Ian C , Plett Jonathan M , Plett Krista L 
Published: April 2023

Abstract
Ectomycorrhizal (ECM) fungi are key players in forest carbon (C) sequestration, receiving a substantial proportion of photosynthetic C from their forest tree hosts in exchange for plant growth-limiting soil nutrients. However, it remains unknown whether the fungus or plant controls the quantum of C in this exchange, nor what mechanisms are involved. Here, we aimed to identify physiological and genetic properties of both partners that influence ECM C transfer. Using a microcosm system, stable isotope tracing, and transcriptomics, we quantified plant-to-fungus C transfer between the host plant Eucalyptus grandis and nine isolates of the ECM fungus Pisolithus microcarpus that range in their mycorrhization potential and investigated fungal growth characteristics and plant and fungal genes that correlated with C acquisition. We found that C acquisition by P. microcarpus correlated positively with both fungal biomass production and the expression of a subset of fungal C metabolism genes. In the plant, C transfer was not positively correlated to the number of colonized root tips, but rather to the expression of defence- and stress-related genes. These findings suggest that C acquisition by ECM fungi involves individual fungal demand for C and defence responses of the host against C drain.
Yca1 metacaspase: diverse functions determine how yeast live and let die
Authors: Lam Darren K , Sherlock Gavin 
Published: April 2023

Abstract
The Yca1 metacaspase was discovered due to its role in the regulation of apoptosis in Saccharomyces cerevisiae. However, the mechanisms that drive apoptosis in yeast remain poorly understood. Additionally, Yca1 and other metacaspase proteins have recently been recognized for their involvement in other cellular processes, including cellular proteostasis and cell cycle regulation. In this minireview, we outline recent findings on Yca1 that will enable the further study of metacaspase multifunctionality and novel apoptosis pathways in yeast and other nonmetazoans. In addition, we discuss advancements in high-throughput screening technologies that can be applied to answer complex questions surrounding the apoptotic and nonapoptotic functions of metacaspase proteins across a diverse range of species.
What News Outlets do People Have in Mind When They Answer Survey Questions about Trust in “Media?”
Authors: Tsfati Yariv , Strömbäck Jesper , Lindgren Elina , Boomgaarden Hajo G , Vliegenthart Rens 
Published: April 2023

AbstractWhile ample research on audience trust in the news media uses survey questions that ask respondents about their trust in a generic “news media,” only scant research has investigated what types of news outlets respondents have in mind when answering such questions. These previous investigations originated mostly in the US and resulted in inconsistent findings. To further investigate this question, we use data from a large-scale survey (N = 2,337), collected in Sweden, including both general media trust measures and specific measures about trust in 20 mainstream and nonmainstream news outlets. The results demonstrate that our respondents seemingly averaged across all mainstream sources when they formed their general evaluations of the news media’s trustworthiness.
Incrementally predictive runtime verification
Authors: Ferrando Angelo , Delzanno Giorgio 
Published: March 2023

Abstract
Runtime verification is a lightweight formal verification technique used to verify the runtime behaviour of software (resp. hardware) systems. Given a formal property, one or more monitors are synthesized to verify the latter against a system execution. A monitor can only conclude the violation of a property when it observes such a violation. Unfortunately, in safety-critical scenarios, this might happen too late for the system to react properly. In such scenarios, it is advised to use predictive runtime verification, where monitors are capable of anticipating (by using a model of the system) future events before actually observing them. In this work, instead of assuming such a model is given, we describe a runtime verification workflow where the model is learnt and incrementally refined by using process mining techniques. We present the approach and the resulting prototype tool.
A New Headache Worse at Night and When Bending Down
Authors: Ceriani Claire E. J. , Yuan Hsiangkuo 
Published: March 2023

Abstract
The chapter entitled “A New Headache Worse at Night and When Bending Down” discusses the variable presentations of patients with sinus disease–related headache and the clinical features that should prompt further investigation for a secondary cause; the co-occurrence of primary headache and sinus disease; the utility and limitations of published diagnostic guidelines; and the treatment and complications of rhinosinusitis. Headache due to sinus disease can be difficult to diagnose. Primary headache disorders may present with the facial pain and nasal symptoms commonly associated with sinus pathology, and rhinosinusitis may not always present with typical symptoms. Familiarity with the diagnostic guidelines and their limitations is essential to diagnosing rhinosinusitis.
An optimal envelope ejection efficiency for merging neutron stars
Authors: Tanaka Alexander M , Gilkis Avishai , Izzard Robert G , Tout Christopher A 
Published: April 2023

ABSTRACT
We use the rapid binary stellar evolution code binary_c to estimate the rate of merging neutron stars with numerous combinations of envelope ejection efficiency and natal kick dispersion. We find a peak in the local rate of merging neutron stars around α ≈ 0.3–0.4, depending on the metallicity, where α is the efficiency of utilizing orbital energy to unbind the envelope. The peak height decreases with increasing electron-capture supernova kick dispersion σECSN. We explain the peak as a competition between the total number of systems that survive the common-envelope phase increasing with α and their separation, which increases with α as well. Increasing α reduces the fraction of systems that merge within a time shorter than the age of the Universe and results in different mass distributions for merging and non-merging double neutron stars. This offers a possible explanation for the discrepancy between the Galactic double neutron star mass distribution and the observed massive merging neutron star event GW190425. Within the α–σECSN parameter space that we investigate, the rate of merging neutron stars spans several orders of magnitude up to more than $1\times 10^{3} \, \mathrm{Gpc}^{-3}\, \mathrm{yr}^{-1}$ and can be higher than the observed upper limit or lower than the observed lower limit inferred thus far from merging neutron stars detected by gravitational waves. Our results stress the importance of common-envelope physics for the quantitative prediction and interpretation of merging binary neutron star events in this new age of gravitational wave astronomy.
Fruit crops combating drought: Physiological responses and regulatory pathways
Authors: Liu Xiaomin , Gao Tengteng , Liu Changhai , Mao Ke , Gong Xiaoqing , Li Chao , Ma Fengwang 
Published: April 2023

AbstractDrought is a common stress in agricultural production. Thus, it is imperative to understand how fruit crops respond to drought and to develop drought-tolerant varieties. This paper provides an overview of the effects of drought on the vegetative and reproductive growth of fruits. We summarize the empirical studies that have assessed the physiological and molecular mechanisms of the drought response in fruit crops. This review focuses on the roles of calcium (Ca2+) signaling, abscisic acid (ABA), reactive oxygen species signaling, and protein phosphorylation underlying the early drought response in plants. We review the resulting downstream ABA-dependent and ABA-independent transcriptional regulation in fruit crops under drought stress. Moreover, we highlight the positive and negative regulatory mechanisms of microRNAs in the drought response of fruit crops. Lastly, strategies (including breeding and agricultural practices) to improve the drought resistance of fruit crops are outlined.
Recent advances in epigenetic triggering of climacteric fruit ripening
Authors: Ji Yinglin , Wang Aide 
Published: April 2023

Abstract
During ripening, fleshy fruits undergo irreversible changes in color, texture, sugar content, aroma, and flavor to appeal to seed-dispersal vectors. The onset of climacteric fruit ripening is accompanied by an ethylene burst. Understanding the factors triggering this ethylene burst is important for manipulating climacteric fruit ripening. Here, we review the current understanding and recent insights into the possible factors triggering climacteric fruit ripening: DNA methylation and histone modification, including methylation and acetylation. Understanding the initiation factors of fruit ripening is important for exploring and accurately regulating the mechanisms of fruit ripening. Lastly, we discuss the potential mechanisms responsible for climacteric fruit ripening.
Effect of a Behavioral Therapy-Based Virtual Reality Application on Quality of Life in Chronic Low Back Pain
Authors: Groenveld Tjitske D. , Smits Merlijn L.M. , Knoop Jesper , Kallewaard Jan Willem , Staal J. Bart , de Vries Marjan , van Goor Harry 
Published: April 2023

Objectives:
Low back pain is the leading cause of years lived with disability with a large impact on quality of life and resistance to a broad array of current treatments. This study aimed to investigate the effect of a novel self-administered behavioral therapy-based virtual reality (VR) application on the quality of life of patients with nonspecific chronic low back pain (CLBP).

Methods:
A pilot randomized controlled trial was conducted in adults with nonspecific CLBP with moderate to severe pain, waiting for treatment in a teaching hospital-based pain clinic. The intervention group used a self-administered behavioral therapy-based VR application for at least 10 minutes daily for 4 weeks. The control group received standard care. The primary outcome was quality of life at 4 weeks measured by the short form-12 physical and mental scores. Secondary outcomes were daily worst and least pain, pain coping strategies, activities of daily living, positive health, anxiety, and depression. Discontinuation of therapy and adverse events were analyzed as well.

Results:
Forty-one patients were included. One patient withdrew due to personal reasons. No significant treatment effect was found for the short form-12 physical score (mean difference: 2.6 points; 95% CI: −5.60 to 0.48) and mental score (−1.75; −6.04 to 2.53) at 4 weeks. There was a significant treatment effect for daily “worst pain score” (F [1, 91.425] = 33.3, P < 0.001) and “least pain score” (F [1, 30.069] = 11.5, P = 0.002). Three patients reported mild and temporary dizziness.

Discussion:
Four weeks of self-administered VR for CLBP does not improve quality of life, however, it may positively affect daily pain experience.