bluuebunny/crossref_metadata_2025_split huggingface dataset:
A clinical case of edematous syndrome: diagnostic search and treatment tactics of a complex patient in compliance with the internarial and domestic recommendations
Authors: Nikiforova Y. V. , Nesen A. O. , Myroshnychenko M. S. 
Published: June 2023

Edematous syndrome is quite common in modern clinical practice. Swelling is one of the most common complaints that cause the patient to consult a doctor and often become the first clinical manifestation of many diseases. Fluid makes up approximately 3/5 of the human body weight, 70% of which is located in cells, and about 30% is extracellular. There is a constant exchange of electrolytes and other substances involved in metabolism between the cell and the extracellular fluid. Subcutaneous connective tissue under normal conditions contains a minimal amount of fluid. Edema fluid formed from blood plasma, which in pathological conditions under the influence of various factors is unable to retain water in the vascular bed, and water accumulates in excessive amounts in the tissues. Often, a patient refers to a doctor with the main complaint — the appearance of edema, and the correct interpretation of the origin of edema is important at this stage, because they are often a marker that reflects the severity and/or decompensation of the disease. Therefore, a detailed and comprehensive differential diagnosis of the edematous syndrome allows choosing the optimal tactics of the patient’s treatment.
The authors present a clinical case of diagnostic search and treatment tactics for edematous syndrome based on global and national recommendations. Patient V., 1983 year of birth, on May 8th, 2023, visited a nephrologist at the L. T. Mala National Therapy Institute. She believed that kidney disease caused swelling of her face and lower limbs. However, considering the long history of intestinal dysfunction, protein loss and edema, the case was revised as a manifestation of gastroenterological pathology. The patient was referred to a gastroenterologist. An extensive diagnostic search was conducted, which allowed not only to establish the correct diagnosis, but also to administer an effective therapy.
Anxiety-depressive disorders in patients with arterial hypertension who were in a combat zone
Authors: Koval S. M. , Rieznik L. A. , Starchenko T. G. 
Published: June 2023

Objective — to study the frequency and severity of anxiety‑depressive disorders in patients with arterial hypertension (AH) who were in the war zone.
Materials and methods. Examinations involved 42 patients with AH of the II stage, 2—3 degree (20 men and 22 women), aged from 46 to 65 years (average age — (52.4±4.3 years), who were in the combat zone during the war in the city of Kharkiv and Kharkiv region of Ukraine. The degree and stage of hypertension were assessed in accordance with current recommendations. All subjects underwent general clinical laboratory and instrumental examination, as well as psychological testing using special questionnaires: Hospital Anxiety and Depression Scale — HADS, Hamilton Anxiety Scales (HAM‑A), Hamilton Depression Scales (HAM‑D), Spielberger‑Hanin Personality and Reactive Anxiety Scales, Posttraumatic Stress Disorder (PTSD) Screening Questionnaire (MH of Ukraine, 2016) and the Civilian Mississippi Scale for PTSD. Statistical analysis of the obtained data was carried out with standard methods using Microsoft Excel 7.0 and «SPSS 19.0» application programs.
Results. The anxiety and depressive disorders of varying severity, and PTSD symptoms have been established in the majority of AH patients, who were in the combat zone. The most frequent anxiety disorders were subclinical anxiety (according to HADS), anxiety symptoms and anxiety state (according to the (HAM‑A). Examinations with the use of Spielberger Personality and Reactive Anxiety Scale — Khanin showed an increased level of both personal and reactive anxiety, but the frequency of high‑level reactive anxiety was significantly higher than this indicator of personal anxiety. In the vast majority of examined patients with AH, subclinical depression (according to HADS) and mild or moderate depressive disorder (according to HAM‑D) have been established. In a third of the patients, depressive disorders were combined with anxiety disorders. Some of the patients with AH after being in the combat zone showed individual PTSD symptoms or developed clinical variant of PTSD (according to the Civilian Mississippi Scale for PTSD). Clinically expressed signs of anxiety and depression and PTSD symptoms were significantly more common in women than in men.
Conclusions. The negative impact of the presence of patients with hypertension in the combat zone on mental health indicators was established. In most of the examined patients, it was manifested as anxiety and depressive disorders of various degrees of severity, and PTSD symptoms. These violations require early diagnosis and timely adequate correction.
The effects of complex therapy with the additional dapagliflozin intake on the copeptin level in the blood serum of patients with diabetic nephropathy
Authors: Nesen A. O. , Semenovykh P. S. , Savicheva K. O. , Galchinska V. Y. 
Published: June 2023

Objective — to determine the effects of drug therapy with inclusion of sodium‑glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin on the blood levels of copeptin as a biomarker of renal and vascular lesions in patients with diabetic nephropathy (DN) at various disease stages.
Materials and methods. Examinations involved 83 in‑hospital patients with DN, treated in the clinic of L. T. Mala National Institute of Therapy. Patients were divided into 2 groups depending on the therapy. 42 patients received a standard course of treatment, including antidiabetic drugs, renin‑angiotensin‑aldosterone system blockers and statins. In addition to standard therapy, the remaining 41 patients were administered SGLT2 inhibitor dapagliflozin in a dose of 10 mg per day. Patients were re‑examined after 6 months treatment. Determination of the copeptin level in blood serum was carried out by the enzyme immunoassay method using the set of reagents Human CPP Elisa Kit manufactured by FineTest, China.
Results. The results of investigation of the effects of complex nephroprotective therapy on the lipid profile indicators in patients with type 2 diabetes mellitus (DM2) demonstrated significant decrease in the levels of total cholesterol by 11.78% (р <0.05), triglycerides by 19.75% (р <0.05) and non‑significant increase of high‑density lipoproteins by 5.10%. In patients with DM2 and with glomerular filtration rate (GFR) >90 mL/(min · 1.73 m2) (I stage chronic kidney disease (CKD)) the level of copeptin after treatment decreased by 19.3% (p <0.05); in patients with (DM2) and GFR of 60—89 mL/(min · 1.73 m2) (CKD II stage) — by 18.9% (p <0.05), and with GFR of 45—59 mL/(min · 1.73 m2) (CKD III stage) — by 24.8% (p <0.05). The significant decrease of copeptin levels was revealed in diabetic patients with both preserved and reduced GFR. In DM2 patients with normal GFR, the copeptin level after standard treatment decreased by 17.6% (p <0.05), and in case of dapagliflozin administration by 20.6% (p <0.05). In patients with reduced GFR, blood serum copeptin levels decreased by 18.9% (p <0.05) after standard therapy, and by 22.1% (p <0.05) under the influence of dapagliflozin.
Conclusions. Complex therapy with the use of SGLT2 inhibitor dapagliflozin contributed to more significant reduction of copeptin levels in patients with DN compared to the standard treatment, regardless of the kidneys’ functional state. The decrease of copeptin levels against the background of the improved main clinical and laboratory parameters indicates not only an improvement in the kidneys’ functional state, but also reduction of cardiovascular risk in this group of patients.
TPACK: Teachers' Needs
Authors: Adnan Aryuliva , Yunisari Caca 
Published: June 2023

The advancement of technology develops a new framework in the education field, known as TPACK. It integrates the theory of pedagogy, content, and technology. Using mix method (qualitative-quantitative) research design, the researchers’ goal was to know the implementation of TPACK in designing lesson plans by English teachers. Furthermore, the researchers decided to use purposive sampling for each education level (junior, senior, and vocational schools) in West Sumatera. To gain the data, the researchers conducted document analysis, observation, questionnaires, and interviews. After analyzing the data, it was found that the teachers in terms of preparing the lesson, the result showed teachers’ pedagogical competence was higher than technological and content knowledge because they adopted lesson plans from the internet. However, regarding the competent of teachers in teaching and learning process, it seemed that they were more competent in technology compared with pedagogy and content knowledge because novice teachers were more familiar in using technology compared to experienced teachers. Surprisingly, in terms of assessment, the teachers were more competent in pedagogy compared with technology and content knowledge. However, content knowledge were not illustrate significantly since they could not understand and develop learning material based on students’ needs. In conclusion, teachers’ competence with TPACK were still below average in terms of understanding the concept, implementation, and assessment, so that they need workshop and seminar to improve their teaching quality and TPACK understanding and implementation.
وقت الفراغ وتأثيره على الطفل
Authors: احمد رغد , قنبر فراس 
Published: June 2023

من المؤكد أن وقت الفراغ مرتبطة بطبيعة البناء الدائم في المجتمع وبمستوى التطور الحضاري ودرجة تعقد الحياة الاجتماعية والنظام الانتاجية والتكنولوجية ، ويكون للفراغ في المجتمعات معنى خاصاً اذ يرتبط اساسا بالوقت المخصص للراحة فضلاً عن المشاركة في بعض مجالات الأنشطة الجماعية النمطية التي يكون لها شكلا طقسياً لكن هذه المشاركة لا تكون في نظرهم أسلوب لقضاء وقت الفراغ لكلها تعني طريقة منظمة للحياة في المجتمع واجب تعليمها واتباعها للأطفال .هدف هذا البحث لمعرفة فوائد ومضار وقت الفراغ وتأثيراته الإيجابية والسلبية على الطفل ، ولقد برز بتسليط الضوء على وقت الفراغ واهم انواعه وخصائصه ومدى تأثيره في شخصية الطفل ونموه الذاتي . لقد برزت نتائج عديدة لهذه الدراسة أهمها:

متابعة الوالدين لأبنائهم واستغلال وقت فراغهم.
ان العامل الاقتصادي للأسرة له تأثير في استغلال وقت الفراغ عند الأطفال.
هناك فروق ذات دلالة احصائية بين عمر الطفل ومراعاة الوالدين للفوارق العمرية بما يخص تقسيم وقت الفراغ لأطفالهم.
FEATURES OF TECHNICAL INSPECTION OF ADJACENT EXISTING BUILDING OBJECTS
Authors: KOSTYRA Nataliia , BAKULINA Valentina 
Published: June 2023

In connection with the wear and tear of a large number of buildings and structures, the volume of work on the technical inspection of building structures is constantly increasing. The need to carry out such work arises in cases of elimination ofdefects made during design, manufacture and installation; in the process of eliminating the consequences of emergency situations; as a result of natural disasters (earthquakes, fires, explosions, subsidence, floods, etc.); reconstruction and modernization of buildings, evaluation of the physical and moral value of structural elements, nodes and details; making decisions about repair, trengthening and restoration of structures; determination of the value of fixed assets during privatization; execution of a secured bank loan; technical certification of buildings and structures.Inspection of buildings and engineering structures is the most important part of the complex of works on evaluating the technical condition of structures and the building as a whole. During the survey, the actual bearing capacity and operabilityof building structures and foundations should be established in order to use these data to determine their further operation or development of the reconstruction project. At the same time, they perform a search for optimal options for a constructive and planning solution, ways of possible strengthening of load-bearing structures taking into account manufacturability, ensuring a minimum of labor costs, material resources and time for their implementation.Evaluation of the degree of wear and tear of building structures or engineering structures is performed, as a rule, during their technical inspection, as well as for making economic (revaluation, terms of sale, insurance, etc.) decisions.Buildings and structures, regardless of their class of consequences (responsibility), are subject to physical and moral wear and tear.The necessity to find effective methods forstrengthening the future constructions is spontaneously scientifically advanced to induce rational models of the future deforming.
Updated analysis – OlympiA study: Chance of cure in early and locally advanced gBRCA-associated breast cancer
Authors: Lubennikova E. V. , Artamonova E. V. 
Published: June 2023

PARP inhibitors have been successfully used in the treatment of BRCA-associated metastatic breast cancer in recent years. Adjuvant therapy for gBRCAm carriers with HER 2-negative high-risk early-stage breast cancer has become a new indication for the use of olaparib.This publication highlights the results of an updated analysis of the OlympiA trial that has changed clinical practice. Adjuvant treatment with olaparib for 1 year signifiantly increased survival rates. Four-year IDFS for the olaparib group was 82.7 % vs 75.4 % for placebo group.Four-year OS was 89.8 % in the olaparib group and 86.4 % in the placebo group. The treatment has a favorable safety profie and does not reduce quality of life. Despite impressive results the OlympiA study raises many questions about the possibilities of integrating PARP inhibitors into modern standards for the treatment of early breast cancer. The main points of contention and possible ways to resolve them are discussed in this review.
Enhancing algal growth and nutrient recovery from anaerobic digestion piggery effluent by an integrated pretreatment strategy of ammonia stripping and flocculation
Authors: Qian Jun , Xu Chengyu , Song Hanwu , Zhou Wenguang , Toda Tatsuki , Li Hongwu , Takayama Yoshiki , Sekine Mutsumi , Koga Shinichi , Li Jun , Liu Jin 
Published: June 2023

Anaerobic digestion piggery effluent (ADPE) with a quite high ammonium (NH4+) concentration and turbidity (dark brown color) generally requires high dilution before microalgae cultivation, owing to its NH4+ toxicity and color inhibition to algal growth. An integrated pretreatment strategy of ammonia stripping and chemical flocculation may be a more practical pretreatment procedure for enhancing algae yield and nutrient recovery from anaerobic digestion piggery effluent. In this study, we determined the optimum pretreatment strategy of anaerobic digestion piggery effluent for subsequent microalgae cultivation and nutrient recovery. The results showed that the integrated anaerobic digestion piggery effluent pretreatment strategy of high-temperature ammonia stripping and chemical flocculation at a mixed dosage of 2 g L−1 polyaluminum chloride (PAC) and 40 mg L−1 cationic polyacrylamide (C-PAM), and 50 mg L−1 ammonium nitrogen (NH4+-N) enrichment provided maximum algal yield (optical density = 1.8) and nutrient removal (95.2%, 98.7%, 99.3%, and 78.5% for the removal efficiencies of total nitrogen, NH4+-N, total phosphorus, and chemical oxygen demand, respectively) from anaerobic digestion piggery effluent. The integrated pretreatment strategy is expected to become a more practical pretreatment procedure for enhancing algae yield and nutrient recovery from anaerobic digestion piggery effluent.
Humoral immune responses to inactivated COVID-19 vaccine up to 1 year in children with chronic hepatitis B infection
Authors: Zhou Yingzhi , Chen Zhiwei , He Yi , Peng Xiaorong , Chang Yunan , Tan Aoxue , Li Hu , Cai Dachuan , Hu Peng , Chen Min , Peng Mingli , Xu Hongmei , Ren Hong 
Published: June 2023

BackgroundInactivated SARS-CoV-2 vaccination has recently been approved for children aged 3-17 years in China. However, data on long-term humoral responses to inactivated vaccines in children with chronic hepatitis B (CHB) are still limited.MethodsIn this prospective observational study, CHB children after primary inactivated SARS-CoV-2 vaccines were recruited consecutively and followed up for 1 year. CHB adults from another cohort study (NCT05007665) were used as a control. The receptor-binding domain IgG antibody (anti-RBD-IgG), neutralizing antibody (NAb), neutralization against Omicron (BA2.12.1, BA.4 and BA.5), and memory B -cell (MBC) responses were evaluated.ResultsOverall, 115 CHB children and 351 CHB adults were included in this analysis. The antibody titers decreased over the first ~180 days and then plateaued up to 1 year in CHB children. However, lower and faster declines in antibody responses were observed in CHB adults. Interestingly, the seroprevalence of antibodies was still high after over 8 months in CHB children (anti-RBD-IgG [90%] and NAbs [83%]). However, neutralization against Omicron subvariants was significantly reduced in CHB children (-3.68-fold to -8.60-fold). Notably, neutralization against the BA.5 subvariant was obviously diminished in CHB children compared with adults. Moreover, CHB children had similar RBD-specific MBCs but higher RBD-specific atypical MBCs compared with adults.ConclusionInactivated vaccination could elicit more robust and durable antibody responses to the wild-type SARS-CoV-2 strain in CHB children than in CHB adults but showed inferior responses to Omicron subvariants (especially to the BA.5 strain). Hence, new Omicron-related or all-in-one vaccines are needed immediately for CHB children.
Personalized remotely guided preventive exercise therapy for a healthy heart (PRIORITY): protocol for an assessor-blinded, multicenter randomized controlled trial
Authors: De Wilde Camille , Bekhuis Youri , Kuznetsova Tatiana , Claes Jomme , Claessen Guido , Coninx Karin , Decorte Elise , De Smedt Delphine , Hansen Dominique , Lannoo Matthias , Van Craenenbroeck Emeline M. , Verhaeghe Nick , Cornelissen Véronique A. 
Published: June 2023

AimsA key treatment for patients with varying stages of heart failure with preserved ejection fraction (HFpEF) is exercise. Yet, despite a Class 1A recommendation, only one-third of patients exercise sufficiently. A huge treatment gap exists between guidelines and clinical practice. PRIORITY aims to establish the feasibility, clinical effectiveness and cost-effectiveness of a hybrid centre and home-based personalized exercise and physical activity intervention for patients along the HFpEF continuum.MethodsAn assessor-blinded, multicenter randomized controlled trial will be conducted among 312 patients along the HFpEF continuum. Participants will be randomized (1:1) to the PRIORITY intervention or a comparator group receiving only a written exercise prescription. Participants in the PRIORITY group will receive 18 supervised centre-based exercise sessions during one year, supplemented with a remotely guided home-based physical activity program. Outcomes will be assessed at baseline, 4 months, one and two years. The primary outcome is the peak oxygen uptake (pVO2) at 1-year. Secondary outcomes include physical activity, other physical fitness parameters, cardiovascular health, echocardiographic parameters, health-related quality of life and costs at 1-year FU. Machine learning algorithms will analyse big data on physical activity collected during the 1-year intervention to develop models that can predict physical activity uptake and adherence as well as changes in fitness and health. A cost-utility analysis will be performed to evaluate the cost-effectiveness of the PRIORITY intervention compared to the control condition.DiscussionWe anticipate that participants in the supervised home-based exercise intervention group will have a greater increase in pVO2 compared to those receiving a written exercise prescription.Trial registration numberThis trial is registered at ClinicalTrials.gov (NCT04745013) and is currently in the recruitment stage.
Seasonal variations of nitrous oxide in a populous urban estuary and its adjacent sea
Authors: Tseng Hsiao-Chun , Yuh Han Yokie Tai , Lin Chia-Chia , Gong Gwo-Ching 
Published: June 2023

The first investigations of seasonal N2O variations and water-to-air fluxes in the Tamsui River estuary and its adjacent sea were carried out in this study. In the Tamsui River estuary, the concentration of N2O decreased with increasing salinity. The seasonal variations of N2O concentrations in the estuary were 46.8–148.5 nM in autumn, 15.9–82.5 nM in spring, 11.0–42.0 nM in summer and 13.1–120.6 nM in winter. When salinity regressed to zero, N2O concentration was highest in autumn, followed by winter, spring, and summer, which might be influenced by the DO and NO3− concentrations as well as temperature. Because of mountains occlusion, the seasonal variations in wind speed were not large in the Tamsui River estuary. Seasonal variations of N2O fluxes in the estuary were 10.9–35.6 μmol m−2 d−1 in autumn, 2.8–15.1 μmol m−2 d−1 in spring, 2.4–9.5 μmol m−2 d−1 in summer and 2.7–26.8 μmol m−2 d−1 in winter. In the adjacent sea of Tamsui River estuary, seasonal average N2O concentrations in the surface seawater were 10.3 ± 0.2 nM in autumn, 11.6 ± 1.2 nM in spring, 11.4 ± 0.7 nM in summer and 13.8 ± 0.9 nM in winter, with no significantly seasonal changes while wind speed varied greatly seasonally. Seasonal variations of average N2O fluxes in Tamsui River estuary’s adjacent sea were 40.3 ± 0.7 μmol m−2 d−1 in autumn, 19.7 ± 2.1 μmol m−2 d−1 in spring, 20.9 ± 1.3 μmol m−2 d−1 in summer and 49.0 ± 3.3 μmol m−2 d−1 in winter. As a result, seasonal variations in N2O fluxes in the estuary were dominated by N2O concentrations in the water, whereas in the sea, it was dominated by wind speed. Overall, the Tamsui River estuary and its adjacent sea were net sources of atmospheric N2O with annual average fluxes 10.6 ± 6.7 and 32.5 ± 14.5 μmol m−2 d−1, respectively.
Regional assessment of trash in Southern California coastal watersheds, United States
Authors: McLaughlin Karen , Mazor Raphael , Sutula Martha , Schiff Kenneth 
Published: June 2023

Trash impairment of watersheds has been recognized as a worldwide environmental problem. Trash monitoring in streams and rivers is necessary to enhance our understanding of its effects on freshwater habitats and the role of streams as a conduit for transport to marine environments. Southern California, with a population of over 22 million, is home to nearly 7,400 km of wadeable streams in watersheds spanning a variety of land uses, making it an ideal region to study the extent and magnitude of trash and trash types (plastic, metal, glass, etc.) and identify relationships between land use and the amount of trash. These data can be used to develop mitigation strategies and evaluate management successes. We found that 77% of Southern California’s coastal stream kilometers contained trash, with an estimated stock of 7 million pieces of trash. Of the types enumerated, plastic trash was the most ubiquitous, present in 69% of stream kilometers, and the most abundant, with an estimated stock of over 4.3 million pieces of plastic. The most common items were single-use plastic containers, wrappers, and plastic bags. Urban land use was associated with the greatest extent and magnitude of trash, with levels nearly double those found in open land uses. Trash was strongly associated with indicators of human activity and development in watersheds. Road density and proximity to roads and parking lots were strongly associated with increased trash in watersheds. This survey also suggested that management actions had a positive effect on trash count. After the previous trash survey in Southern California streams in 2011–2013, a statewide ban on plastic bags was implemented in 2016. We found a significant decrease in the number of plastic bags within streams in the present survey compared to the previous survey.