bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic Effects and QTc Changes with Intravenous Phenytoin and Fosphenytoin during Propofol and Sevoflurane Anesthesia
Authors: Maremanda Krishna R. , Geetha Singam , Reddy Bakkireddy S. , Durga Padmaja , Bramarambha Kolli L. 
Published: May 2023

AbstractBackground Phenytoin is a commonly used antiepileptic drug (AED) for postoperative seizure prophylaxis; it is associated with adverse cardiovascular effects. Fosphenytoin is considered a safer alternative but can produce prolongation of QT interval. This hypothesis generating pilot study evaluated the changes in hemodynamics and the heart rate corrected QT interval (QTc) with phenytoin and fosphenytoin during propofol and sevoflurane anesthesia.Methods Eighty American Society of Anesthesiologists I and II patients aged 20 to 60 years undergoing elective supratentorial craniotomy requiring a loading dose of the intraoperative AED for seizure prophylaxis were randomized into four groups: group PP, receiving propofol (0.2 mg/kg/min) for maintenance and phenytoin (15 mg/kg) for seizure prophylaxis; group SP, receiving sevoflurane (1 minimal alveolar concentration) for maintenance and phenytoin(15mg/kg) for seizure prophylaxis; group PF, receiving propofol for maintenance and fosphenytoin (22.5 mg/kg) for seizure prophylaxis; and group SF, receiving sevoflurane for maintenance and fosphenytoin for seizure prophylaxis. The heart rate, systolic, diastolic, mean arterial pressure, and QTc were measured at baseline before anesthesia, during maintenance of anesthesia, and during various phases of AED infusion and up to 1 hour after completion of AED administration. Appropriate statistical analysis was done and a two-tailed p-value of less than 0.05 was considered significant.Results The incidence of changes in the heart rate and hypotension was not significant among the groups. Administration of fosphenytoin significantly prolonged QTc, which was more remarkable when coadministered with sevoflurane than with phenytoin.Conclusion Fosphenytoin did not confer hemodynamic benefits over phenytoin. Fosphenytoin produces prolongation of QTc, and when coadministered with sevoflurane, the prolongation is more significant, suggesting a possible additive effect.
Failure of Sequential Compression Device Detected by Neuromonitoring during Minimally Invasive Posterior Scoliosis Surgery
Authors: Raue Kristen D. , Shils Jay , Fessler Richard G. 
Published: May 2023

AbstractIntraoperative neuromonitoring is recommended as standard practice for corrective scoliosis surgery. Common methods include somatosensory-evoked potentials (SSEPs) and transcranial motor-evoked potentials (TcMEPs), which have been shown to have a high diagnostic accuracy in detecting new neurological deficits postoperatively. Sequential compression devices (SCDs) are a common method for thromboprophylaxis in spine surgery and are not known to have many device-related complications. To date, there have been no reports of lower extremity ischemia secondary to SCD deflation failure detected by multimodality neuromonitoring during minimally invasive posterior spine surgery. We, therefore, present a case report of an 18-year-old male with adolescent idiopathic scoliosis who underwent minimally invasive posterior spinal fusion with instrumentation. Intraoperative decrease in SSEPs and TcMEPs were noted in the left leg shortly after incision before any instrumentation or reduction occurred. Further examination revealed that the left leg was hypoperfused compared with the right leg and that the left SCD was not properly deflating. Bilateral SCDs were removed, and perfusion and neuromonitoring returned to baseline immediately. Bilateral SCDs and the machine were replaced, and neuromonitoring remained within normal limits for the rest of the surgery. The patient had no postoperative neurologic or vascular deficits. Early detection of lower extremity ischemia by neuromonitoring resulted in the prompt identification and addressing of SCD malfunction, sparing devastating neurological and vascular injury to the patient's leg. This case reinforces the importance of neuromonitoring within spine surgery.
Pregnancy and Acute Lymphoblastic Leukemia: A Case Series and Review of Literature
Authors: Bhattacharjee Sukrita , Ghosh Shouriyo , Ray Siddhartha Sankar , Samanta Sambit , Sinha Nilanjan , Saha Sandeep , Bhattacharyya Maitreyee 
Published: May 2023

AbstractAcute lymphoblastic leukemia (ALL) diagnosed during pregnancy is rare and causes ethical and therapeutic challenges. We performed a retrospective search of ALL patients (n = 202) treated at our institution from 2015 to 2020 and found five patients diagnosed during pregnancy. In this report, we discuss the individual patients in detail and the challenges faced during their treatment. The use of established lymphoblastic leukemia treatment protocols and the modifications made therein to prevent untoward chemotherapy-related toxicities to the fetus are discussed in this study. We report the second use of rasburicase during pregnancy in literature with favorable maternal and fetal outcomes. We also present an extensive literature review of 41 cases of ALL in pregnancy previously reported. It is important to note that there is a dearth of guidelines for the treatment of these complex situations, and although certain general principles can be established, an individualized approach is needed in most cases of leukemia diagnosed during pregnancy.
Effect of a Patient Navigator Program to Address Barriers to Eye Care at an Academic Ophthalmology Practice
Authors: Zarnegar Arman , Cassidy Julie , Stone Andre , McGinnis-Thomas Dana , Wasser Lauren M. , Sahel José-Alain , Williams Andrew M. 
Published: May 2023

Abstract
Purpose The aim of this study was to determine whether a patient navigator program can address patient-reported barriers to eye care and to understand patient perceptions of a patient navigator program in ophthalmology.
Design This is a retrospective cohort study and cross-sectional patient survey.
Subjects and Methods A cohort of patients was recruited from a single academic ophthalmology department in the Mid-Atlantic region. Patients included in the study had received referral to the patient navigator program in the first quarter of 2022. Our patient navigator program provided patients with resources to address barriers to care such as transportation and financial assistance. Outcomes of the study included indications for referral, case resolution rate, and patient satisfaction.
Results In total, 130 referrals for 125 adult patients were included. The mean ± standard deviation age was 59 ± 17 years, 54 (44%) were male, 77 were white (62%), and 17 patients (14%) were uninsured. Common reasons for referral were transportation (52, 40%), insurance (34, 26%), and financial assistance (18, 14%). Among the 130 cases referred, 127 (98%) received an intervention from the patient navigator, who was able to resolve the referring issue in 90% of cases (117/130). Among 113 patients contacted for a follow-up telephone survey, 56 (50%) responded. Patients rated the program highly at a mean Likert rating of 4.87 out of 5. Moreover, 72% (31/43) of respondents stated their interactions with the patient navigator assisted them with taking care of their eyes.
Conclusions A patient navigator program can address barriers to eye care by connecting patients with community resources.
Dirofilaria repens in a Pediatric Patient—First Case Report from Switzerland
Authors: Rose Rebekka , Kleitsch Kai-Uwe , Born Diana , Heye Pascal 
Published: May 2023

AbstractWe report the first case of Dirofilaria repens in a 4-year-old male patient in Switzerland. The disease is a vector-borne parasitic infection that is not endemic to Switzerland. A 4-year-old male presented with a tender mass in the left groin. The patient was taken to the operating room for surgical exploration to rule out a pathology that could be harmful to the spermatic cord. A node was found along the spermatic cord and excised. Histopathology and microbiology studies revealed the diagnosis of Dirofilaria repens.Even though Switzerland is not endemic to Dirofilaria repens, the diagnosis of a parasitic infection should be considered in patients presenting with subcutaneous nodules in correlation with a travel history to endemic areas. The treatment consists of complete excision of the affected tissue.
Large Cyst of Skene Gland: A Rare Perineum Mass
Authors: Tzelepis Konstantinos , Zacharouli Konstantina , Samara Athina A. , Koutras Antonios , Kontomanolis Emmanuel N. , Perivoliotis Konstantinos , Pavlidou Efterpi , Sotiriou Sotirios 
Published: May 2023

Abstract
Objective In this report we present a rare case of a large cyst of Skene gland in a female patient with a palpable vaginal mass persisting for at least 2 years.
Case Report A 67-year-old female admitted to the department of urology due to the presence of “a vaginal mass” for the past 2 years. A cyst of Skene's duct was suspected based on clinical manifestation and findings of magnetic resonance imaging showing an extensive cyst formation in the upper vaginal area and anterior to the urethra. Based on these findings, a decision for surgical removement of the cyst was made. The cyst was incised, drained, and marsupialized. The postoperative recovery was uneventful, and the patient was discharged on the second postoperative day.
Conclusion High clinical suspicion is important to reach this rare diagnosis. Partial excision and marsupialization of the cyst is a simple procedure with low morbidity, without recurrence, and excellent results.
Impact of Ablation during Index Hospitalization on All-Cause Mortality in Patients with Typical Atrial Flutter: Insights from National Multicenter Database
Authors: Amer Muhammad , Annie Frank H. , Adhikari Shubash , Mukherjee Debabrata 
Published: May 2023

Abstract
Background We sought to assess the impact of ablation during index hospitalization (IH) on all-cause mortality (ACM) in patients presenting with newly diagnosed typical atrial flutter (tAFL) as compared with patients without ablation, irrespective of optimal rate or rhythm control medications.
Methods We identified patients with newly diagnosed tAFL in the TriNetX Research Network between January 20, 2010, and January 20, 2021. Using International Classification of Diseases, 10th revision (ICD-10) codes, patients were stratified into those who had undergone ablation during IH and those who did not undergo the procedure. Results were assessed using propensity score matching (PSM) analysis as well as Kaplan–Meier curves.
Results A total of 12,986 (N) patients (aged 35–85 years) met our inclusion criteria. Of those, 3,665 had undergone ablation during IH compared with 9,321 patients who did not. Patients in the ablation group (mean age 64.3 ± 10.1 years) had a higher prevalence of hypertension (80 vs. 78.3%, p = 0.02), respectively. PSM created two well-matched groups of 3,652/3,652 patients each with an ACM of ablation of 4.5 versus 7.8% (p = 0.01) at 6 months, 6.6 versus 11.4% (p = 0.01) at 12 months, and 14.5 versus 20.9% (p < 0.001) at 36 months of follow-up. Survival data were confirmed through Kaplan–Meier analysis using a log-rank test.
Conclusion From a large, federated, multicenter population database, we report significant survival benefit of ablation during IH in patients presenting with new tAFL diagnosis. Kaplan–Meier mortality curves confirmed survival advantage with ablation at 6, 12, and 36 months of follow-up in this cohort.
Person restrictions in non-canonical agreement patterns in
Spanish
Authors: Ausín Adolfo , Depiante Marcela 
Published: May 2023

Abstract
In this paper we present empirical evidence for
the existence of person restrictions across five constructions which
exhibit non-canonical agreement patterns in Spanish. We account for
these data by adopting a Multiple Agree approach à la
Anagnostopoulou (2005,
2017) and D’Alessandro (2007) where
T/INFL can agree with two different elements as long as there is no
person feature incompatibility.
We also show that there are person restrictions
in non-canonical agreement constructions with
parecer in Spanish (contra Mare and Pato, 2018), once
we set aside the “look-like” interpretation of
parecer. In addition, we provide empirical
evidence for the claim that usted(es) behaves as an
“imposter” as expected by Collins and Ordóñez (2021) analysis.
The emergence of sound change in two varieties of Spanish
Authors: Pollock Matthew , Delgado-Díaz Gibran , Galarza Iraida , Díaz-Campos Manuel , Willis Erik W. 
Published: May 2023

Abstract
We examine social and linguistic factors,
including lexical frequency, that influence variable production of
the alveolar rhotic trill in Caracas, Venezuela, and the region
surrounding Caguas, Puerto Rico. Two categories of rhotic
productions are established: non-innovative trills with two or more
occlusions and innovative reduced ones with fewer than two
occlusions and possible frication. Phonetic context, rhotic
duration, and lexical frequency conditioned trill production in both
varieties; mixed-effect logistic regressions showed that shorter
duration and high frequency tokens predicted use of innovative
variants in both varieties, while low vowels also did so in Caracas.
This suggests that Caracas and Caguas are experiencing variation
reflective of the early stages of a linguistic change, with
linguistic factors conditioning reduced variants.
Promoting Spanish L2 pragmatic competence in a virtual
environment
Authors: Collentine Karina , Collentine Joseph 
Published: May 2023

Abstract
Virtual Environments (VE) can mimic the myriad
dimensions that native speakers take into account in authentic
social interactions and are one of the instructional conditions
(e.g., methodological approaches, learning affordances) that can be
used to promote pragmatic competence. The present study employs
big-data techniques to provide a parsimonious and quantifiable model
of affordance usage in VEs fostering L2 Spanish learners’ pragmatic
abilities. We employ data-reduction analyses to synthesize tracking
data that recorded learners’ use of software features within
consciousness-raising and structured-input, both involving
task-based language teaching (TBLT). The analysis suggests that
three macro variables can significantly classify different learning
conditions: (i) movement through the VE, (ii) type of interaction
with affordances providing input, (iii) time on task.
Effectiveness of exergames programme to modify body composition and health‐related physical fitness in adolescents with down syndrome after COVID‐19 quarantine
Authors: Suarez‐Villadat Borja , Sadarangani Kabir P. , Villagra Ariel 
Published: May 2023

ABSTRACTAims: to determine the effect of a 20‐week exergame program on different indicators of body composition and components of health‐related physical fitness in adolescents with Down syndrome. Methods and Procedures Outcomes: 49 adolescents (19 female and 30 males; average age, 14.19 ± 2.06 years) with Down syndrome were recruited and randomized to two groups (control group vs. intervention group). Adolescents allocated in the control group carried out a physical activity program three times a week for 20 weeks meanwhile adolescents allocated in the exercise group performed an exergame program three times a week for 20 weeks. Results: The exercise group had significant improvements in all health‐related physical fitness variables and there is an improvement in some body composition variables (p < 0.05). Conclusions and Implications: 20 week exergame program consisting of 3 sessions of 60 minutes is able to improve levels of body composition and health‐related physical fitness in adolescents with Down syndrome.Highlights

Research in body composition and health‐related physical fitness of people with Down syndrome has revealed that an exergame programme increases levels of health‐related physical fitness in adolescents with Down syndrome
An exergame programme can improve differences in markers of body composition between the control group and the intervention group
The intervention group that performed the exergame programme showed increases in health‐related physical fitness levels after 20 weeks of intervention.
The control group that performed a based on developing motor behaviour programme did not show differences in body composition or health‐related physical fitness after 20 weeks of intervention.
Synthesized partially unzipped carbon nanotubes and potential DNA/CNTs interactions
Authors: Fouda A N , Almaqwashi Ali A 
Published: May 2023

Abstract
Carbon nanotubes (CNTs) are structurally considered to be graphene nano-ribbons (GNRs) that rolled up into seamless tubes. While CNTs nanotechnology is advancing, synthesis of GNRs from CNTs is sought after for precise and integrative graphene applications. Acid treatment of CNTs can generate longitudinal unzipping in an effective, large scale and economic approach. However, further understanding of CNTs-to-GNRs degradation, which mimics biodegradation molecular processes by oxidants, can also aid to assess toxicological impact of biodegraded CNTs. In this study, unzipping of multi-wall carbon nanotubes (MWCNTs) was established using a strong oxidizing agent. The influence of oxidation on the morphological, crystalline quality and dielectric properties was investigated. In particular, partial unzipping of CNTs was confirmed by transmission electron microscopy (TEM), and scanning electron microscopy (SEM) images. Broad band dielectric spectroscopy (BDS) was utilized to depict the influence of the applied frequency on the dielectric properties. GNRs exhibited a lag in the drop of capacitance and impedance to higher values of frequency with respect to the starting MWCNTs. Furthermore, DNA interactions with partially unzipped carbon nanotubes, were computationally assessed by employing molecular docking. The obtained potential DNA-CNT molecular conformations were illustrated and their biomolecular implications were discussed.
Topological effects on generalized Duffin-Kemmer-Petiau oscillator under Aharonov–Bohm flux field and Coulomb potential
Authors: Candemir Nuray , Ahmed Faizuddin 
Published: May 2023

Abstract
In this paper, we study the relativistic quantum motions of the oscillator field of the wave equation under the influence of the Aharonov–Bohm (AB) flux field with a Coulomb vector potential in the background of the topological defects produced by a cosmic string and global monopole space-time. We derive the radial equation of the generalized Duffin-Kemmer-Petiau (DKP) oscillator in a static cosmic string space-time and solve it through the Heun function equation. Afterwards, we derive the radial equation of the same generalized DKP oscillator in a point-like global monopole background and obtain the eigenvalue solutions using the same procedure. The generalized oscillator field is studied by substituting the radial momentum operator ∂
r
→ (∂
r
+ i
M
ω
η
0
f(r)), where f(r) is an arbitrary function other than linear and introduces a vector potential of Coulomb-types through a minimal substitution via ∂
μ
→ (∂
μ
− i
q
A

μ
) in the relativistic wave equation. It is shown that the eigenvalue solutions of the oscillator field are influenced by the topological defects of the cosmic string and point-like global monopole space-times and get them modified. Furthermore, we see that the eigenvalue solutions depend on the geometric quantum phase, and hence, shifted them more in addition to the topological defects that show the gravitational analogue to the Aharonov–Bohm effect for the bound-states.
Generation and characteristics of an anomalous Airy vortex beam from a Lommel vortex beam
Authors: Qiu Yuanhuang , Liu Zhirong 
Published: May 2023

Abstract
A practical method for generating an anomalous Airy vortex beam is proposed, and characteristics of this novel kind beam are investigated. Results show that orbital angular momentum (OAM) quantum number n could be used to modulate the profiles of vortex rings, asymmetric parameter c would cause the beam rotation and phase distortion, and when increase control parameters α and β, more energy would concentrate on the side lobes, and the side lobes in the x-direction and y-direction separately would expand laterally and longitudinally, respectively. Particularly, the position and moving direction of the light spot could be controlled precisely according to the actual needs by altering the phase shift proportional coefficients p and q. Our work would extend potential applications of the mixed vortex beams in optical micro-manipulation and optical trapping.
Ultra faint edge on galaxies: standard and alternative gravity explorations
Authors: O’Brien James G. , Kerin William M. , Chiarelli Thomas L. 
Published: May 2023

Abstract
Recently, Bizyaev et. al. (2021) conducted the first modeling of rotation curves for 153 ultra-faint, edge-on galaxies using the 3.5 m telescope at the Apache Point Observatory. These models derived high resolution rotation curves for 20 galaxies of various sizes and spiral morphologies, making new estimates of the optical scale lengths. Using the derived models, in this work we make the first fits to the rotation curves using alternative gravity, namely conformal gravity, Modified Newtonian Dynamics (MOND) and more. A robust analysis is shown including the derived rotation curve fits to the alternative gravity models, along with how the models account for empirical phenomena such as the Baryonic Tully Fisher relation and the Radial Acceleration Rule. This data is not only modern, but unique in that certain galaxies are shown to be able to be fit by standard gravity alone without dark matter.
Applying Retardation Theory to Galaxies
Authors: Wagman Michal , Horwitz Lawrence P. , Yahalom Asher 
Published: May 2023

Abstract
The missing mass problem has been with us since the 1970s, as Newtonian gravity using baryonic mass cannot account for various observations. We investigate the viability of retardation theory, an alternative to the Dark Matter paradigm (DM) which does not seek to modify the General Principal of Relativity but to improve solutions within it by exploring its weak field approximation to solve the said problem in a galactic context. This work presents eleven rotation curves calculated using Retardation Theory. The calculated rotation curves are compared with observed rotation curves and with those calculated using MOND. Values for the change in mass flux to mass ratio are extracted from the fitting process as a free fitting parameter. Those quantities are interpreted here and in previous works using given galactic processes. Retardation Theory was able to successfully reproduce rotation curves and a preliminary correlation with star birthrate index is seen, suggesting a possible link between galactic winds and observed rotation curves. Retardation Theory shows promising results within current observations. More research is needed to elucidate the suggested mechanism and the processes which contribute to it. Galactic mass outflows carried by galactic winds may affect rotation curves.