bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-Hospital Pulse Glucocorticoid Therapy in Patients with ST-Segment Elevation Myocardial Infarction Transferred for Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial (PULSE-MI)
Authors: Madsen Jasmine Melissa , Obling Laust Emil Roelsgaard , Rytoft Laura , Folke Fredrik , Hassager Christian , Andersen Lars Bredevang , Vejlstrup Niels , Bang Lia Evi , Engstrøm Thomas , Lønborg Jacob Thomsen 
Published: August 2023

Abstract
Background
Inflammation in ST-segment elevation myocardial infarction (STEMI) is an important contributor to both acute myocardial ischemia and reperfusion injury after primary percutaneous coronary intervention (PCI). Methylprednisolone is a glucocorticoid with potent anti-inflammatory properties with an acute effect and is used as an effective and safe treatment of a wide range of acute diseases. The trial aims to investigate the cardioprotective effects of pulse-dose methylprednisolone administered in the pre-hospital setting in patients with STEMI transferred for primary PCI.
Methods
This trial is a randomized, blinded, placebo-controlled prospective clinical phase II trial. Inclusion will continue until 378 patients with STEMI have been evaluated for the primary endpoint. Patients will be randomized 1:1 to a bolus of 250 mg methylprednisolone intravenous or matching placebo over a period of 5 minutes in the pre-hospital setting. All patients with STEMI transferred for primary PCI at Rigshospitalet, Copenhagen University Hospital, Denmark will be screened for eligibility. The main eligibility criteria are age ≥ 18 years, acute onset of chest pain with < 12 hours duration, STEMI on electrocardiogram, no known allergy to glucocorticoids or no previous coronary artery bypass grafting, previous acute myocardial infarction in assumed culprit, or a history with previous maniac/psychotic episodes. Primary outcome is final infarct size measured by late gadolinium enhancement on cardiac magnetic resonance (CMR) three months after STEMI. Secondary outcomes compromise key CMR efficacy parameters, clinical endpoints at three months, the peak of cardiac biomarkers, and safety.
Discussion
We hypothesize that pulse-dose methylprednisolone administrated in the pre-hospital setting decreases inflammation, and thus reduces final infarct size in patients with STEMI treated with primary PCI.
Trial registration
EU-CT number: 2022-500762-10-00; Submitted May 5, 2022. ClinicalTrials.gov Identifier: NCT05462730; Submitted July 7, 2022, first posted July 18, 2022
Gamma-Aminobutyric Acid Type A Receptor Encephalitis Primarily Manifesting as Cognitive Dysfunction and Subclinical Epilepsy: A Case Report and Literature Review
Authors: Li Jin Yao , Yang Xin , Huang Zhi Qiang , Tu Min , Wang Peng Li , Xiong Cheng , Liu Quan Sheng 
Published: August 2023

Abstract
Background: Anti-γ-aminobutyric acid type A receptor (anti-GABAA R) encephalitis is a neurological disorder that primarily manifests as cognitive dysfunction and seizures. Affected patients rarely present with subclinical epilepsy; thus, they are prone to misdiagnosis and underdiagnosis due to a lack of available tests during early disease stages.
Case presentation: An 83-year-old male presented with a 20-day history of progressively worsening hypomnesis. On admission, cognitive dysfunction was indicated based on a Simple Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores of 8 and 4, respectively. Electroencephalography (EEG) showed paroxysmal spike-slow complex wave bursts in all regions, and cerebrospinal fluid was positive for anti-GABAA R β3 antibodies (titer 1:3.2). The patient was diagnosed with anti-GABAA acid A encephalitis and treated with methylprednisolone sodium succinate, gamma globulin, and mycophenolate mofetil capsules. After treatment, hypomnesis gradually improved, and EEG findings transitioned from paroxysmal spike-slow complex wave bursts in various regions to clusters of predominantly theta and delta waves. Thereafter, the patient was discharged from the hospital. After discharge, the patient continued taking oral methylprednisolone and mycophenolate mofetil capsules, but self-discontinued methylprednisolone after one month. At the five-month follow-up, the hypomnesis was significantly improved, and MMSE and MoCA scores were 18 and 14, respectively, revealing moderate cognitive impairment.
Conclusions: Anti-GABAA R encephalitis manifesting clinically as cognitive dysfunction and subclinical epilepsy is rare. Therefore, early, comprehensive, and meticulous ancillary examinations with timely and effective treatment planning are crucial for improving the duration of recovery and prognosis of the disease.
Comparative Analysis of Three Types of Whey as Substrate for Fermentation by Kluyveromyces marxianus and its Influence on Isoamyl Acetate Synthesis
Authors: Hernández-Cruz Miguel Ángel , Cadena-Ramírez Arturo , Castro-Rosas Javier , Páez-Lerma Jesús Bernardo , Ramírez-Vargas María del Rocío , Rangel-Vargas Esmeralda , Romo-Gómez Claudia , Lara-Gómez Ariadna Bárbara , Conde-Báez Laura , Gomez-Aldapa Carlos Alberto 
Published: August 2023

Abstract
Whey, the main byproduct in cheese manufacturing, has a high organic content, predominantly due to its lactose amount (45-60 g/L). There are three types of residues coming from cheese production: sweet whey (SW), acid whey (AW), and ricotta whey (RW). Each one presents physicochemical particularities that pose challenges when handled by small and medium enterprises, due to their costly treatment. An alternative to address this issue is the fermentation of such substrates to obtain value-added products. The goal of this research was to evaluate the fermentation with Kluyveromyces marxianus in the three types of raw whey for the production of isoamyl acetate, a compound responsible for the banana aroma. Several factors were analyzed: cellular growth, pH variations, reduction in lactose content, ethanol production, and isoamyl acetate generation. Cellular growth showed no significant differences between the three types of whey. Regarding pH, a decrease was recorded during the first 48 hours down to an approximate value of 4.3, then it increased to reach values close to 7. In acid whey, 50.95 g/L of ethanol was obtained at 120 hours. On the other hand, the maximum observed production of isoamyl acetate was 160 mg/L. Finally, the maximum lactose consumption was observed in sweet whey, with an approximate percentage of 76% at 24 hours, higher than that of acid and ricotta whey, which ranged between 56 and 58%.
Association and Path Analyses amongMorpho-agronomic Traits, Fatty Acids Contents and Oil Yield in Linseed (Linumussitatisimum L.) Genotypes in Ethiopia
Authors: Ghiday Tadesse , Mohamed Wassu , Tsehaye Yemane , Wakjira Adugna , Daba Chemeda , Dissasa Tesfaye 
Published: August 2023

Abstract
The improvement for a trait of interest can be achieved by both direct and indirect selection of characters that are more heritable and easy to select. The aim of this study was to determine the degree and nature of associations among morphoagronomic taits, fatty acid contents and oil yield. One hundred twenty six (120 accessions and six improved varieties) linseed (Linum usitatissimum L.) genotypes were evaluated for their morphoagronomic taits, fatty acid contents and oil yield using a Alpha lattice Design with two replications at farm fields of Holeta agricultural research center (HARC) and Kulumsa agricultural research center (KARC) during 2019/2020 cropping season in Ethiopia. At genotypic and phenotypic levels seed yield per plant had highly significant positive correlations with plant height, number of primary braches per plant, number of secondary braches per plant, number of capsules per plant, number of seeds per capsule, thousand seed weight, biological yield per plant and oil yield per plant, indicating that selection based on these parameters would considerably enhance seed yield per plant. Oil yield per plant had positive and highly significant phenotypic and genotypic correlation coefficients with plant height, number of primary branches, number of secondary branches, number of capsules per plant, number of seeds per capsule, thousand seed weight, biological yield per plant, linolenic fatty acid andseed yield per plant, indicating that selection based on these parameters would considerably enhance oil yield per plant. Biological yield per plant and seed yield per plant revealed positive and the highest direct effect on seed yield per plant and oil yield per plant, respectively. Selection to improve seed yield and oil yield per plant will be effective through biological yield per plant and seed yield per plant, respectively.
Urgent Needs for Second Life Using and Recycling Design of Wasted E-car Lithium-ion Battery: A Scientometric Analysis
Authors: Zahoor Aqib , Kun Róbert , Mao Guozhu , Farkas Ferenc , Sápi András , Kónya Zoltán 
Published: August 2023

Abstract
By 2030, 12–13 million tons of used electric vehicle batteries (EVBs) will reach the end of their service life, after 1st life cycle of these batteries still 60–70% of their energy storage capacity and can be first is reused for “2nd life” purpose (SLB) up to 5 to 10 years as stationary instruments before sending to recycling and extracting of valuable contents in the end-life processes (ELB). This research used bibliometrics analysis, combine with social and S-curve analysis to quantitatively analyze 4,810 SCI and SSCI databases articles from 2001 to 2021 related to SLBs and ELBs of used EVBs. Results reveal that: (1) In last 20 years publications on SLBs and recycling have been continually increasing. (2) China had highest 645 publications, secondly Germany with 635 publications, and U.S.A at thirdly with 634 publications. Several countries are providing facilities and finding ways to commercialize SLBs after 1st used. Our assessment on application of SLBs in stationary purposes the storage of solar and wind energy are promising systems, (3) keywords and S-Curve analysis for ELB articles illustrate that hydrometallurgy and biometallurgical were the top recycling technologies and attached with great potential soon. According to the EU commission and release battery directive, hydrometallurgical is the powerful and best recycling method. Finally, we provide comprehensive assessment of both SLBs and ELBs such as economic and environmental benefits, commercial and domestic applications, recycling steps, and low GHGs (i.e., greenhouse gas) emission. Our analyses and information will benefit for decision makers and researchers for present and future opportunities in this field.
Hyperuricemia and the risk of stroke incidence and mortality: a systematic review and meta-analysis
Authors: Jiang Haiyan , Su Yunyi , Liu Ruixue , Lin Yapeng , Yi Si , Zhai Xi , Huang Chunmei , Yang Jie 
Published: August 2023

Abstract
Background.
The relationship between hyperuricemia (HUA) and stroke remains controversial. The aim of this systematic re-view was to assess the association between hyperuricemia and stroke.
Methods.
PubMed, Embase, Web of Science and Cochrane Library were searched from their earliest records to June 5th, 2023, additional papers were identified through a manual search. Prospective studies that provided a multivariate-adjusted estimate of the association between hyperuricemia and risk of stroke incidence and mortality, represented as relative risks (RRs) with 95% confidence intervals (CIs), were eligible.
Results.
A total of 22 studies including 770532 adults were eligible and included. Hyperuricemia was associated with a significantly increasing risk of both stroke incidence (combined RR, 1.42; 95%CI, 1.31–1.53) and stroke mortality (combined RR, 1.53; 95%CI, 1.18–1.99) in our meta-analyses. Relative risk of stroke incidence: females (combined RR, 1.67 ; 95%CI, 1.44–1.92) and males (combined RR, 1.13; 95%CI, 1.02–1.25). Relative risk of mortality: female (combined RR, 1.41 ; 95%CI, 1.31–1.52) and males (combined RR, 1.27; 95%CI, 1.20–1.34). The association between hyperuricemia and ischemic stroke (IS) (combined RR, 1.39; 95%CI, 1.31–1.47) was more significant than that of hemorrhagic stroke (HS) (combined RR, 1.13; 95%CI, 1.02–1.26).
Conclusion.
Our study verified an association between hyperuricemia and risk of stroke, which was more pronounced in females.
Comparison of ultrasound Guided saline enema (USGSE) and X-ray guided air enema in the treatment of Intussusception reduction in Children
Authors: Lian Dan-Dan , Sun Chen 
Published: August 2023

Abstract

To compare the effect of ultrasound guided saline enema (USGSE) and X-ray fluoroscopic air enema in the reduction of intussusception in children. Eighty children with intussusception were randomly divided into ultrasonic-guided saline enema reduction in 40 cases (USGSE group) and X-ray air enema reduction in 40 cases (air enema group). The enema pressure, success rate, average time and cost of the two methods were compared. The average operation time of the USGSE group was lower than that of the air group [(5.35±1.79) min vs. (6.03±2.41) min, P=0.159], the average pressure of the air group was higher than that of the air group [(10.95±1.54) kPa vs. (9.6±1.26) kPa, P < 0.001], the success rate of resetting was higher than that of the air group (87.5% vs. 85.0%, P=0.745), and the cost of resetting was lower than that of the air group [(339.23±10.73) yuan vs. (378.23±18.20) yuan, P < 0.001]. Subgroup analysis showed that the success rate of enema treatment in children with onset time < 48 h was significantly higher than that in children with onset time ≥48 h (98.30% vs. 54.50%, continuous correction χ２=22.16, P < 0.001). The success rate and operation time of USGSE in pediatric intussusception reduction are similar to that of air enema, and the advantages of low cost and no radiation are worthy of popularization. For children with onset time ≥48 h, enema reduction is safe and effective, but the conversion rate to open is high. It is necessary to carefully identify the symptoms of intestinal perforation and necrosis on the basis of strictly following the indications to avoid delayed treatment.
Health and Wellness Characteristics of Employees Enrolled in a Workplace Wellness Study in the United Arab Emirates: A Descriptive Analysis
Authors: Mohammad Alshafi , Paulo Marília Silva , Hosani Salama Al , Jabri Omar Al , Yafei Zain Al , Datta Sonali , Koornneef Erik 
Published: August 2023

Abstract
Introduction: Modifiable health behaviors have the power to increase (or decrease) the risk of chronic diseases, impacting a population’s health and life span. Health and wellness programs can potentially play a major role in initiating and supporting positive changes in health behaviors, which may lead to improving an individual’s health span and reducing the risk of premature mortality. A better understanding of the health and well-being status of the population is crucial to the design of proper and effective interventions. This study aimed to describe the health and well-being status of a cohort of 123 employees in the United Arab Emirates.
Methods and analysis: This study reports the demographic characteristics, body composition, cardiovascular fitness, functional fitness, biological age, and well-being of 123 employees from a large health sector company enrolled in a workplace wellness study in the United Arab Emirates. Employees were invited to participate in an intervention that was designed to validate the efficacy of weekly health and wellness challenges. Descriptive statistics were used to describe the employees' distribution.
Results: The mean age of participants was 39.2 years old, 80% of them were non-Emirati, and the majority were from Middle-Eastern and South Asian ethnicities. The prevalence of overweight, obesity, hypercholesterolemia, hyperlipidemia, prediabetes, diabetes was 35%, 29%, 34%, 79%, 30%, 7%, respectively. Almost half of the participants (47%) were prehypertensive for systolic blood pressure, 80% had fitness category of poor-very poor, and majority (60%) reported exercising <150 minutes/week. The mean functional fitness score was 12.2 points, which indicated an increased risk of injury with physical activity.
Conclusions: The findings of this study suggest that despite the advancements in healthcare in the UAE, several key preventable risk factors are still prevalent in its population. The introduction of health and wellness programs can support healthier lifestyles to achieve improvements in quality of life and health expectancy among the UAE population.
Study on Complex Attention Between Yoga and Non-yoga Female Group
Authors: Ghosh Kaberi , Gayen Arup , Mondal Samiran 
Published: August 2023

Abstract
Background
Complex attention reflects the ability to control, shift, and divide attention focus, allowing for the manipulation of information and execution of multiple steps to accomplish a goal. Regular yoga practice may influence complex attention.
Aim of the study:
The present study was aimed to compare the complex attention between yoga and non-yoga group of female subjects.
Methods
A total 33 voluntary female subjects were selected for this study. To achieve the aim of the study, 12 subjects were taken from yoga group (n = 12) and 21 subjects from non-yoga group (n = 21). The age range of the subjects was 16–18 years. Yoga group underwent yoga practices regularly whereas non-yoga group follow their normal life. To collect the data paper pencil test was taken. Complex attention was measured by the following assessment namely six letter cancellation test, digit letter substitution test, digit symbol substitution test, digit span forward test, digit span backward test, trail making test part –A and B.
Results
The present study showed that yoga group was significantly better than non-yoga group of female subjects on six letter cancellation test, digit letter substitution test, digit symbol substitution test, digit span forward test, digit span backward test and trail making test part –B respectively.
Conclusion
On the basis of the result it may be concluded that the female yoga group is better than the female non-yoga group in complex attention.
Symptomatic HIV infection and in-hospital outcomes in acute myocardial infarction undergoing percutaneous coronary intervention: an insight of national inpatients sample
Authors: Cui Mingzhi , Qi Haohong , Zhang Ting , Wang Shixiong , Zhang Xiao , Cao Xiangmei , Ma Xueping , Huang Hui , Yan Ru , Jia Shaobin , Cong Guangzhi 
Published: August 2023

Abstract

HIV infection increases the risk of acute myocardial infarction (AMI). However, little is known about its effect on in-hospital outcomes and temporal trends in AMI patients undergoing percutaneous coronary intervention (PCI). We queried AMI patients who underwent PCI from the National Inpatient Sample Database (2003–2015) and stratified into three groups: symptomatic, asymptomatic, and HIV-negative. After 1:2 case-control matching (CCM), logistic regression analysis was conducted to determine how HIV infection affected in-hospital outcomes, and we also evaluatedtheir recent trends from 2003-2015. A total weighted national estimate of 2,191,129 AMI cases included 2,178,995 HIV/AIDS-negative cases, 4,994 asymptomatic HIV cases, and 7,140 symptomatic HIV cases. Symptomatic but not asymptomatic HIV patients endured an over tripled in-hospital mortality (aOR 3.84, 95% CI 2.63-5.62), over two-fold of the acute kidney injury (aOR 1.90, 95% CI 1.42–2.54) and the cardiac shock risk (aOR 1.83, 95% CI 1.24-2.70), a longer length of hospital stay (beta 1.27, 95% CI 1.04-1.51), and had more procedures (beta 1.30, 95% CI 1.16-1.44). These disparities related to symptomatic HIV infection lasted from 2003 to 2015. In AMI patients who underwent PCI procedures, symptomatic HIV infection is associated with higher in-hospital mortality and severe outcomes.
Understanding Long-term Requirements in Pulmonary Rehabilitation for COPD: Insights from Interviews with Respiratory Care Professionals
Authors: Chien Shih-Ying , Wong Alice May-Kuen , Tseng Winston , Hu Han-Chung , Cho Hsiu-Ying 
Published: August 2023

Abstract
Chronic obstructive pulmonary disease (COPD) is characterized by persistent obstruction to airflow through the lungs and long-term respiratory symptoms. Apart from dyspnea, a critical characteristic of patients with COPD is an impaired capacity to exercise, which limits their ability to participate in daily activities and severely impacts their quality of life. To provide a precise and effective exercise prescription, it is necessary to translate exercise science into evidence-based recommendations for pulmonary rehabilitation (PR).
This study aims to enhance our understanding of the continuous requirements for long-term PR in COPD patients. To achieve this, a series of semi-structured investigations will be conducted, focusing on three key aspects: exploring the essential tasks and conditions for implementing PR, identifying the specific requirements for assistive devices, and examining the health management practices for patients after hospital discharge. The interviews were carried out with a convenience sample of 24 respiratory care professionals who possess an average of 17 years of relevant clinical work experience and are actively involved in providing PR services to COPD patients.
Interviews were transcribed verbatim, and analysis was undertaken to identify the following themes: (1) Necessary Conditions for Clinical Pulmonary Rehabilitation ; (2) The Need for Assistive Devices in Pulmonary Rehabilitation ; and (3) Post-Discharge Care for Patients with Chronic Lung Disease.
Our findings indicate that the implementation of exercise training to enhance the exercise capacity of COPD patients is a complex process. Barriers associated with respiratory care professionals (RCPs) contribute to the challenges in effectively implementing exercise training programs. These barriers emphasize the importance of precise measurement and monitoring of physiological parameters. Furthermore, it is crucial to consider individual differences, limitations in workplaces and medical resources, and the effective utilization of technology for continuous monitoring of patient recovery.
Heading towards carbon neutrality: How marine carbon sinks become an important handle for promoting marine ecological civilization construction?Literature review and research prospect based on the CiteSpace
Authors: Chen Xiaolong , Di Qianbin , Liang Chenlu 
Published: August 2023

Abstract
As an efficient long-term carbon sink, the mechanism of marine carbon sink, carbon sink effect, carbon sink technology, carbon sink accounting and carbon sink trading market construction are becoming new topics that need to be explored in various disciplines. Based on the research literature related to marine blue carbon sink in the core databases of China National Knowledge Internet (CNKI) and Web of Science (WOS), we use bibliometric tools to quantitatively compare and analyze the main characteristics of domestic and foreign marine blue carbon sink research such as publication volume, time, journals, authors and institutions; explore the research hotspots, stage frontier areas and theme evolution trends through keyword clustering, emergent and co-occurring knowledge maps. Finally, the key research directions of marine carbon sinks are prospected, we should take multidisciplinary interdisciplinary research as the leader to promote the unified carbon sink market research of land and sea integration; take comprehensive ecological compensation mechanism of marine carbon sink protection, marine carbon sink related theory and technological innovation research as the guide to continue to explore the application mode of marine carbon sinks In order to explore the blue carbon cooperation mechanism of the countries along the Maritime Silk Road. In order to sort out the current situation of marine carbon sink research at home and abroad, promote the research in this field to a deeper level of scientific and rational development, and provide reference and reference for subsequent scholars to carry out related research.