bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower central incisors location of severe skeletal class Ⅲ malocclusion
Authors: Zhang Jieni , Liang Yuqi , Chen Rui , Chen Si , Lin Jiuxiang , Han Bing , Liu Xiaomo 
Published: January 2023

Abstract
Objective: To systematically explore the angle and stability of lower central incisors in alveolar bone in severe skeletal Class III patients.
Materials and methods: 198 severe skeletal class Ⅲ patients (ANB ≤-4°) who underwent combined orthodontic and orthognathic treatment were divided into three groups based on the mandibular plane angle (SN-MP). Pre-treatment lateral cephalograms were analyzed and compared among the three groups. We also measured11samples’ Cone-beam computed tomography images to invalidate the reliability of the cephalometric analysis.
Results: ANOVA test showed no statistically differences in the angle between long axis of the mandibular union and long axis of the lower central incisor (MIA) among the low angle, normal angle and high angle groups (P＞0.05), while significant differences were found in the angle between the axis of the lower incisor and the mandibular plane (IMPA) among the three groups (P< 0.001). The mean of IMPA decreases with the increase of SN-MP in the 198 severe skeletal Class Ⅲ patients. The mean of MIA in the low angle and normal angle group were 3.70° and 3.52° respectively, while the value (2.33°) was smaller in the high angle group. Paired-samples t Testshowed no statistically differences were found in MP-SN、FH-MP and MIA between the cephalometric measurements and CBCT measurements (P＞0.05).
Conclusions: In severe skeletal Class Ⅲ patients, long axis of the lower central incisors are highly consistent with the long axis of the mandibular union, which was more obvious in the high angle subjects. MIA reflects the physiological inclination of the lower centralincisors better than IMPA.
Videogame training increases clinical well-being, attention and hippocampal-prefrontal functional connectivity in schizophrenia
Authors: Becker Maxi , Fischer Djo , Gallinat Jürgen , Kühn Simone 
Published: January 2023

Abstract

Recent research revealed that videogame training boosts neuronal plasticity emerging in a range of cognitive improvements accompanied by structural and functional brain changes in healthy subjects. A reduction of neuronal plasticity has been suggested in patients with schizophrenia as a pathobiological model of cognitive deficits as well as positive and negative symptoms. Here we test whether videogame related improvements regarding cognition and neuronal plasticity can be transferred to this patient group and even reduce symptoms. Therefore, we conducted a training study in which patients with schizophrenia and healthy controls were randomly assigned to train with a 3D or 2D platformer videogame or read an E-book (active control) for 8 weeks, 30 minutes a day. After training, we observed significant increases in sustained attention (MATRICS Consensus Cognitive Battery) in both video gaming groups compared to the active control group in patients and healthy subjects which was significantly correlated with increased functional connectivity in a predefined hippocampal-prefrontal network. Most importantly, we observed significant improvements in negative symptoms (PANSSneg), general psychopathology (PANSSgen) and perceived mental health recovery (RAS) in patients trained with videogames compared to E-book reading. There was no significant difference in neuronal plasticity (cognition, functional connectivity) between patients and healthy controls. No outcome differences were observed for the 3D versus 2D version of the videogame training. Of note, critical and difficult-to-treat symptoms of schizophrenia namely cognitive deficits, negative symptoms and perceived mental health recovery improved the most. Hence, bringing to bear the core properties of videogames like fostering initiative, goal setting, decision making, in combination with joy and gratification, may constitute a closer to real life training as compared to current psychiatric treatment settings. Further research is needed to explore videogame training as possible adjunctive treatment options in complex mental disorders.
Random Forest Classification of Pichavaram Mangroves through the Integration of Selected Parameters of SAR and Optical Datasets
Authors: Cherian Sandra Maria , K Rajitha 
Published: January 2023

Abstract
Mapping of mangrove forests is a very difficult task due to its complexity in physical characteristics. However, its protection and maintenance area necessity, as they are an ecological hotspot. Synthetic Aperture Radar(SAR) data integrated with optical data has been widely used for wetland application for better classification results. This study assess the applicability of dual polarimetric C-band data (Sentinel-1) in mangroveforest mapping together with Sentinel-2 optical data. Along with that the significance of commonly used spectral indices and SAR parametersare also examined. It was performed by running a separability analysis using Jeffries-Matusita (JM) distance and a multicollinearity analysis using Spearman’s rank correlation. Google Earth Engine platform was used for preprocessing and Random Forest (RF) classification of data.The result generated from multi-season data collected over a year indicated that selection of significant features for classification improved theclassification accuracy of both the optical and the SAR data. The overall accuracy of the optical image and the SAR image increased by 7.0% and 5.0%, respectively. Moreover, integration of feature subsetted fromoptical and SAR data again resulted in a rise in accuracy compared to classification results of SAR and optical data alone. JM distance and correlation analysis identified 23 - 33 features as significant for classification among initial 63 features of optical and SAR data, by reducing data dimensionality. This paper comprehensively discusses the importance of selecting suitable features for the classification of mangrove forests.
Comparison of variable- and person-oriented methodology: examination of Thai and Hungarian psychobiological personality profiles
Authors: Kövi Zsuzsanna , Wongpakaran Tinakon , Wongpakaran Nahathai , Zábó Virág , Mirnics Zsuzsanna 
Published: January 2023

Abstract
Background:
The aim of our study was to compare variable- and person-oriented methodology in understanding group differences in psychobiological personality profiles. We compared two different cultural groups, but methodology can be applied to any group-comparison, such as comparison of different clinical groups. Variable-oriented approach aims to sum the variables into basic factors and compare the different samples by comparing the mean scores of factors. On the other hand, person-oriented methodology unfolds the different holistic patterns of all variables.
Methods:
Altogether 1319 individuals (672 Thai and 647 Hungarian) were included in our study. The distribution of age, gender and education level were matched in order to provide as equal samples as possible. The Zuckerman-Kuhlman-Aluja Personality Questionnaire was administered that measures Aggression, Extraversion, Activity, Sensation Seeking and Neuroticism.
Results:
Our mean-comparison results on factor differences found Thai individuals to be less extraverted, less aggressive, less active and less sensation seeker. Cluster-analytic holistic scale- profiles revealed six typical profiles (two cross-culturally stable and four rather culture-specific profiles. These culturally different holistic profiles help us understand more deeply the cultural differences in personality.
Cluster-analytic approach showed that the rate of reserved individuals and rate of introverted impulsive inividuals are higher among Thai individuals, whereas rate of aggressive-impulsive and rate of positive sensation seekers were higher among Hungarians. Resilients and overcontrolled types appeared in both cultures at similar rate.
Conclusions:
Our results highlight differences in applying variable- or person-oriented approach in group comparison. Variable-oriented approach assumes that summation of variables are equal across groups and group mean differences can be regarded as differences of all individuals equally. On the other hand, person-oriented approach, the cluster-analytic one, assumes that subgroups can be formed and it provides an opportunity to compare groups not only by the average level but through comparing the rates of different holistic profiles.
Outcomes following pancreatic metachronous metastatic renal cell carcinoma resection and comparisons with pancreatic neuroendocrine tumours
Authors: Ji Yuchen , Shen Ziyun , Li Hongzhe , Lu Xiongxiong , Xie Jing , Zhang Jun , Shen Baiyong 
Published: January 2023

Abstract
Background: The aim of this study was to investigate perioperative findings ofpancreatic metachronous metastatic renal cell carcinoma (PmmRCC) and pancreatic neuroendocrine tumours and long-term survival outcomes of PmmRCC in a high-volume single centre.
Methods: The clinicopathological data of 29 PmmRCC patients treated in our centre from January 2013 to December 2021 were collected retrospectively. We analysed demographics, diagnoses, surgical information, 30-day morbidity data, and long-term survival outcomes. Preoperative characteristics and diagnosis were also compared with patients who had pancreatic neuroendocrine tumours during the same period in our centre.
Results: PmmRCC patients were older (P < 0.001), less symptomatic (P = 0.017), more likely to appear hyper-vascular in imaging studies (P = 0.023), had more multiple nodules in the pancreas (P = 0.002), and had a larger tumour size (P = 0.046) than patients with pancreatic neuroendocrine tumours. No metastatic lymph nodes were detected, and 34.5% of PmmRCC cases were preoperatively misdiagnosed. At the last follow-up, 13 patients had tumour progression, and five died (two within 30 days postoperatively).
Conclusions: Clinical characteristics and imaging results exhibited some differences between PmmRCC and pancreatic neuroendocrine tumours. Patients could benefit from PmmRCC surgery with an acceptable co-morbidity. No metastatic lymph nodes were found, even though suspected on imaging examination or detected intraoperatively. However, elucidating the surgical role and necessity of lymphadenectomy requires larger-sample studies.
Network analysis of pig movement data as an epidemiological tool: an Austrian case study
Authors: Puspitarani Gavrila Amadea , Fuchs Reinhard , Fuchs Klemens , Ladinig Andrea , Desvars-Larrive Amélie 
Published: January 2023

Abstract
Animal movements represent a major risk for the spread of infectious diseases in the domestic swine population. In this study, we adopted methods from social network analysis to explore pig trades in Austria. We used a dataset of daily records of swine movements covering the period 2015-2021. We analyzed the topology of the network and its structural changes over time, including seasonal and long-term variations in the pig production activities. Finally, we studied the temporal dynamics of the network community structure. Our findings show that the Austrian pig production was dominated by small-sized farms while spatial farm density was heterogeneous. The network exhibited a scale-free topology but was very sparse, suggesting a moderate impact of infectious disease outbreaks. However, two regions (Upper Austria and Styria) may present a higher structural vulnerability. The network also showed very high assortativity between holdings from the same federal state. Dynamic community detection revealed a stable behavior of the clusters. Yet trade communities did not correspond to sub-national administrative divisions and may be an alternative zoning approach to managing infectious diseases. Knowledge about the topology, contact patterns, and temporal dynamics of the pig trade network can support optimized risk-based disease control and surveillance strategies.
Identification of the mixing ratios of beer-mixed beverages by UV/VIS spectroscopy
Authors: Stinus Sophia , Erban Pauline , Diebold Josef , Schmidt Magnus S. 
Published: January 2023

Abstract
UV/VIS spectroscopy was used in conjunction with a calibration method to determine the mixing ratio of samples of beer-mixed drinks with mineral water (sour Radler beers) from the food service industry. For this purpose, calibration lines were constructed based on absorptions at the two wavelengths 380 nm and 430 nm. To create these calibration lines, blending ratios were prepared from beers of three southwestern German brands and mineral water. The samples of the sour Radler beers were taken from restaurants and bars, which are all located in Baden-Württemberg. It has been shown that the calibration lines can be used to determine mixing ratios with an average deviation of approximately 7% and 9%. Thereby, the calibration line based on the absorption at 430 nm represents a higher accuracy. Using this calibration line, the sour Radler beer samples have percentage ranges of beer of approximately 50–90%. This method could serve as a rapid quantitative quality control of the mixing ratios of sour Radler or other beer-mixed drinks. It could be used in breweries for routine control.
The relevance of Veress needle overshooting reduction; A Survey among 365 surgeons
Authors: Horeman-Franse T. , Postema R.R , Fischer T , Calleja-Agius J , Camenzuli C , Alvino L , Hardon S.F. , Bonjer Jaap 
Published: January 2023

Abstract
Introduction
Safe insertion of the Veress needle in laparoscopy relies on the surgeons’ technical skills in order to stop needle insertion just in time to prevent overshoot in the underlying organs. To reduce this risk, a wide variety of veress needle systems were developed with safety mechanisms that limit de insertion speed, insertion depth or decouples the driving force generated by the hand on the needle. The aim of this study is to evaluate current perceptions related to the use of Veress needles and to investigate the relevance of preventing overshooting of Veress needles among EAES members.
Methods
An online survey was distributed by the European Association of Endoscopic Surgery (EAES) Executive Office to all active members. The survey consisted of demographic data and 14 questions regarding the use of the Veress needle, the conducted training prior to usage, and the need for improvements.
Results
A total of 365 (10%) members responded coming from 58 different countries. Of the responding surgeons, 36% prefers the open method for patients with normal BMI, and 22% for patients with high BMI. Of the surgeons using Veress needle, 68% indicated that the reduction of overshoot is beneficial in normal BMI patients, whereas 78% indicated that this is beneficial in high BMI patients. On average, the members that uses the Veress needle used it for 1448 (SD 3031) times and felt comfortable on using it after 22,9 (SD 78,9) times. The average years of experience was 17,6 (SD 11,1) and the surgeons think that a maximum overshoot of 9.4 (SD 5.5) mm is acceptable before using the system safely.
Conclusion
This survey indicates that despite the risks, Veress needles are still being used by the majority of the laparoscopic surgeons who responded. In addition, the surgeons responded that they are interested in using a Veress needle with extra safety mechanism if it limits the risk of overshooting into the underlying structures.
Lose-lose consequences of bacterial community-driven invasions in soil
Authors: Liu Xipeng , Salles Joana 
Published: January 2023

Abstract
Community-driven invasion, also known as community coalescence, occurs widely in natural ecosystems. Despite that, our knowledge about the process and mechanisms controlling community-driven invasion in soil ecosystems is lacking. Here we performed a set of coalescence experiments in soil microcosms and assessed impacts up to 60 days after coalescence by quantifying multiple traits (compositional, functional, and metabolic) of the invasive and coalescent communities. Our results show invasion-triggered changes in the resident community's succession trajectory and functionality (carbohydrate metabolism), which were dependent on the invasive communities. Moreover, the invasion impact was mainly due to the high suppression of residents rather than the invaders’ survival. The short-term coalescence effect was predicted by the metabolic unevenness of the invasive community, indicating the direct competition between invaders and residents for labile carbon sources at the onset of coalescence. In contrast, the long-term impact was predicted by the compositional (phylogenetic) similarity between invasive and resident communities. Collectively, our results suggest that community coalescences in soil are primarily driven by resource competition – the lose-lose situation – between invaders and residents, and a multi-level trait-based approach could help predict the impact.
Proton therapy re-irradiation provides promising clinical results in recurrent brain meningioma
Authors: Scartoni Daniele , Giacomelli Irene , Pertile Riccardo , Vennarini Sabina , Feraco Paola , Picori Lorena , Annicchiarico Luciano , Sarubbo Silvio , Amelio Dante 
Published: January 2023

Abstract
Purpose
To evaluate the clinical outcomes, toxicity and prognostic factors conditioning survival of reirradiation with Proton therapy for recurrent meningiomas.
Methods
Recurrent meningioma who failed after radiotherapy were re-irradiated with active scanning proton therapy with a median dose of 54 GyRBE (range 50.4-60 GyRBE). Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method. The log rank test was performed to compare the entire survival experience between groups (significant p-value ≤ 0.05). Associations between qualitative variables were analyzed with the Fisher exact test (significant p-value ≤ 0.05).
Results
Thirty-two patients were re-irradiated with Proton therapy (10 grade I, 22 grade II-III). Median tumor volume at the time of re-irradiation was 43 cc (range 1.2-225.5) and median time from prior RT to reirradiation was 66 months (range 4-288). At a median follow-up of 27 months, 1-yr and 2-yr PFS were 89.4% and 74.5% (1-yr and 2-yr PFS were 100% for grade I, 100% and 76% for grade II, 66% and 50% for grade III). 1-yr and 2-yr OS were 86.6% and 83.0% (2-yr OS were 87% for grade I, 86% for grade II, 66% for grade III). Local recurrence rate was 34% with a median time of recurrence of 13.4 months. Five patients (14%) developed radionecrosis with a median time of 3.4 months from the end of PT (range 3-8.8).
Conclusions
Re-irradiation with proton therapy seems to be a safe and effective treatment in patients with recurrent meningioma, also for large volume and aggressive lesions (grade II-III).
Vacuole Membrane Protein 1 (VMP1) Restricts NLRP3 Inflammasome Activation by Modulating SERCA Activity and Autophagy
Authors: Zack Stephanie R. , Nikolaienko Roman , Cook Ben , Melki Ronald , Zima Aleksey V. , Campbell Edward M. 
Published: January 2023

Abstract
Altered expression of vacuole membrane protein 1 (VMP1) has recently been observed in the context of multiple sclerosis and Parkinson’s disease (PD). However, how changes in VMP1 expression may impact pathogenesis has not been explored. Here, we report that genetic deletion of VMP1 from a monocytic cell line resulted in increased NLRP3 inflammasome activation and release of proinflammatory molecules. Examination of the VMP1 dependent changes in these cells revealed that VMP1 deficiency led to decreased SERCA activity and increased intracellular [Ca2+]. We also observed calcium overload in mitochondria in VMP1 depleted cells, which was associated with mitochondrial dysfunction and release of mitochondrial DNA into the cytoplasm and the extracellular environment. Autophagic defects were also observed in VMP1 depleted macrophages. Collectively, these studies reveal VMP1 as a negative regulator of inflammatory responses, and we postulate that decreased expression of VMP1 can aggravate the inflammatory sequelae associated with neurodegenerative diseases like PD.
Connectivity Index of Directed Rough Fuzzy Graphs
and its Application in Traffic Flow Network
Authors: Ahmad Uzma , Nawaz Iqra , broumi said 
Published: January 2023

Abstract
The directed rough fuzzy graph (DRFG) is a fusion of rough and fuzzy theory, because it
deals with incomplete and vague information simultaneously. Connection or the strength of
connectivity (SC) is vital in the realm of circuits or networks that are linked to the real world.
As a result, SC is one of the most essential aspects of a directed rough fuzzy network system. The
neighborhood connectivity index (NCI) is one such parameter that has a variety of applications
in network theory. In this paper, we discuss the notion of NCI in DRFGs using the strength of
vertices to their neighbor vertices. We provide several lower and upper bounds on the NCI of
DRFGs with reference to other graph invariants such as the number of vertices, edges, and degree
distance. When we study NCI in operations for DRFGs with a large number of vertices, the
degree of vertices in a DRFG provides a confusing picture. Therefore, a mechanism to determine
the NCI for DRFG operations is needed. Therefore, generalized formulas for NCI of DRFGs
obtained by operations such as union, composition, and Cartesian product are also developed.
An algorithm for obtaining NCI of DRFGs is also proposed. In addition, an application of NCI
of DRFGs in traffic flow networks was discussed to identify the busiest intersection using the
proposed algorithm. Finally, we gave a complete comparative evaluation and analysis table for
a similar human trafficking system, comparing the results for connectivity index (CI), Wiener
index (WI), and NCI.
Establishing the Catabolic Pathway of Commercial Cypermethrin and Discovering the Inhibitor of 3- Phenoxy Benzoic Acid Biodegradation by Fig Farm Isolated Enterobacter hormaechei strain ZK101 and Stenotrophomonas maltophilia strain ZK102
Authors: KURT Zöhre , KOKANGUL Merve 
Published: January 2023

Abstract
Cypermethrin (CYP) is a commonly used type Ⅱ pyrethroid against pest control in agriculture and household. Its excessive use has the potential to cause serious secondary environmental pollution. Biodegradation in the environment minimizes contamination however the metabolites, could also harm the environment more than the main product of interest. Therefore, optimum degradation rates and possible effects of bioremediation should be understood to evaluate its applicability. In this study, isolates obtained from soil exposed to CYP from fig farms in Adana were investigated to identify their CYP biodegradation pathway, and the key enzymes responsible for biodegradation, to optimize the biodegradation, and to indicate the inhibitors that affect their ability to mineralize CYP. Enterobacter hormaechei strain ZK101 and Stenotrophomonas maltophilia strain ZK102 both degraded CYP with first-order kinetics through esterification followed by 3-phenoxy benzoic acid (3PBA) deoxygenation. Strains accumulated 3PBA when they have been reinoculated to the soil due to the copper present (40 ppm) in the soil causing the inhibition of 3PBA dioxygenase. The work here is the first study that tested the potential of CYP degradation when isolates were re-inoculated in the soil and showed that CYP degraders in the field will cause an accumulation of a more toxic contaminant than CYP. The results of this study help to understand the effects of bacterial applications for CYP contamination and reveal the negative effects of microbial responses in the field.