bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parent, child, and family outcomes following Acceptance And Commitment Therapy for parents of autistic children: A randomized controlled trial
Authors: Maughan Andrea L , Lunsky Yona , Lake Johanna , Mills Jennifer S , Fung Kenneth , Steel Lee , Weiss Jonathan A 
Published: May 2023

Emerging research shows that Acceptance and Commitment Therapy (ACT) may improve mental health for caregivers. Parents of autistic children, adolescents, and adults ( N = 54) were randomly assigned to either complete a brief group-based ACT intervention or remain on the waitlist. Participants completed surveys immediately prior to randomization, and 3-, 7-, and 17-weeks post-randomization. The primary outcome was depression symptoms and secondary outcomes included stress, goal attainment, positive affect, ACT psychological processes, child mental health, and family functioning. Mixed effects linear models testing Group × Time interaction indicated the Treatment group ( n = 27) demonstrated greater post-intervention improvements than the Waitlist group ( n = 27) in parent depression ( p = .03, d = −0.64) and family distress ( p = .04, d = −0.57). Treatment group parents also reported greater short-term gains in positive affect ( p =< .001, d = 0.77) and personal goal attainment ( p = .007, d = 0.80), compared to the Waitlist group. Although there was no significant Group × Time interaction for other outcomes, stress ( b = −2.58, p = .01), defusion ( b = −3.78, p = .001), and experiential avoidance ( b = −4.22, p = .01) showed improvement for the Treatment group, but not the Waitlist group, at post-intervention. All Treatment group improvements were maintained at follow-up. Results suggest that a brief ACT group intervention is efficacious for improving some aspects of mental health for parents of autistic children. Lay abstract Parents of autistic children commonly experience difficulties with their own mental health. This study looked at the effects of a brief group-based Acceptance and Commitment Therapy program, developed for parents of autistic children, youth, and adults. ACT focuses on increasing psychological flexibility, which is the ability to be mindful and accepting of difficult thoughts and experiences, shown to be important for mental wellness. Participants included 54 parents of autistic people, ages 3–34. Parents were randomly divided into two groups: a Treatment group that received the intervention right away, and a Waitlist group that completed the program after the Treatment group completed the trial. All parents filled out questionnaires right before the program began, and at 3, 7, and 17 weeks after randomization. Compared to the group that was waiting to participate in the program, parents in the Treatment group reported greater improvements in depression and family distress, and these improvements were still present 4 months later. Parents in the Treatment group also reported short-term improvements in their positive feelings and personal goals, compared to those waiting. Results showed that ACT may help improve some aspects of mental health for parents of autistic children, but further research is recommended.
Syntactic optionality in heritage Spanish: How patterns of exposure and use affect clitic climbing
Authors: López Otero Julio César , Hur Esther , Goldin Michele 
Published: May 2023

Aims and Objectives: This study explores Spanish heritage speakers’ (HSs) knowledge of clitic climbing and the (extra-)linguistic factors that modulate it. Design: Heritage speakers of Spanish completed three screening tasks (a background language questionnaire, a productive vocabulary task, and proficiency task) and two experimental tasks (an elicited production task, and a forced choice task) examining their knowledge of clitic climbing in different contexts. Data and Analysis: Thirty-nine participants completed two experimental tasks. Each task included 32 critical items distributed in four conditions. The data were analyzed using generalized linear mixed models. Findings: Patterns of language exposure and use are a strong predictor for clitic climbing knowledge while the effects of age of onset of bilingualism found contradict our hypothesis. Originality: This study examines production and interpretation data of clitic climbing knowledge in combination with extralinguistic factors that may facilitate heritage language acquisition and maintenance. Sequential bilinguals show a stronger enclisis bias than simultaneous bilinguals. Significance: The results show that, in cases of optionality, self-reported heritage language exposure and use may be a stronger predictor than age of onset of bilingualism of the dominant language. Limitations: This study does not have acceptability data on either grammatical or ungrammatical instances of proclisis or enclisis. In addition, because the test items feature different verbs, no lexical analysis can be conducted. Finally, using an adapted version of the BLP instead of its original normed version restricts opportunities for comparability and reproducibility.
Does misclassification of former tobacco smokers explain the ‘smoker’s paradox’ in the risk of COVID-19? Insights from the Stockholm Public Health Cohort
Authors: Shaaban Ahmed N. , Andersson Filip , Magnusson Cecilia , Orsini Nicola , Caspersen Ida H. , Peña Sebastian , Karvonen Sakari , Magnus Per , Galanti Maria R. 
Published: May 2023

Background: The association between tobacco smoking and the risk of COVID-19 and its adverse outcomes is controversial, as studies reported contrasting findings. Bias due to misclassification of the exposure in the analyses of current versus non-current smoking could be a possible explanation because former smokers may have higher background risks of the disease due to co-morbidity. The aim of the study was to investigate the extent of this potential bias by separating non-, former, and current smokers when assessing the risk or prognosis of diseases. Methods: We analysed data from 43,400 participants in the Stockholm Public Health Cohort, Sweden, with information on smoking obtained prior to the pandemic. We estimated the risk of COVID-19, hospital admissions and death for (a) former and current smokers relative to non-smokers, (b) current smokers relative to non-current smokers, that is, including former smokers; adjusting for potential confounders (aRR). Results: The aRR of a COVID-19 diagnosis was elevated for former smokers compared with non-smokers (1.07; 95% confidence interval (CI) =1.00–1.15); including hospital admission with any COVID-19 diagnosis (aRR= 1.23; 95% CI = 1.03–1.48); or with COVID-19 as the main diagnosis (aRR=1.23, 95% CI= 1.01–1.49); and death within 30 days with COVID-19 as the main or a contributory cause (aRR=1.40; 95% CI=1.00–1.95). Current smoking was negatively associated with risk of COVID-19 (aRR=0.79; 95% CI=0.68–0.91). Conclusions: Separating non-smokers from former smokers when assessing the disease risk or prognosis is essential to avoid bias. However, the negative association between current smoking and the risk of COVID-19 could not be entirely explained by misclassification.
Support vector regression model for flight demand forecasting
Authors: FAN Wei , WU Xiang , SHI Xin Yang , ZHANG Chong , Wai Hung Ip , Kai Leung Yung , ZENG Li Shun 
Published: May 2023

Flight demand forecasting is a particularly critical component for airline revenue management because of the direct influence on the booking limits that determine airline profits. The traditional flight demand forecasting models generally only take day of the week (DOW) and the current data collection point (DCP) adds up bookings as the model input and uses linear regression, exponential smoothing, pick-up as well as other models to predict the final bookings of flights. These models can be regarded as time series flight demand forecasting models based on the interval between the current date and departure date. They fail to consider the early bookings change features in the specific flight pre-sale period, and have weak generalization ability, at last, they will lead to poor adaptability to the random changes of flight bookings. The support vector regression (SVR) model, which is derived from machine learning, has strong adaptability to nonlinear random changes of data and can adaptively learn the random disturbances of flight bookings. In this paper, flight bookings are automatically divided into peak, medium, and off (PMO) according to the season attribute. The SVR model is trained by using the vector composed of historical flight bookings and adding up bookings of DCP in the early stage of the flight pre-sale period. Compared with the traditional models, the priori information of flight is increased. We collect 2 years of domestic route bookings data of an airline in China before COVID-19 as the training and testing datasets, and divide these data into three categories: tourism, business, and general, the numerical results show that the SVR model significantly improves the forecasting accuracy and reduces RMSE compared with the traditional models. Therefore, this study provides a better choice for flight demand forecasting.
Incidence of Nonunion of the First Metatarsophalangeal Joint Arthrodesis After Failed Implant Arthroplasty: A Systematic Review
Authors: So Eric , Wilson Matt , Chu Anson K. , Thompson John M. , Prissel Mark A. 
Published: May 2023

Joint arthroplasty of the first metatarsophalangeal (MTP) joint is an accepted surgical option for patients with hallux rigidus. However, this procedure has been reported to have a high complication rate and unpredictable survivorship. Implant arthroplasty failure is a devastating complication that results in significant osseous defect with altered biomechanics of the foot. Commonly, salvage options are limited to arthrodesis with bone grafting. However, outcomes are rarely reported. The purpose of this study is to investigate the fusion rates of first metatarsophalangeal joint arthrodesis after conversion from failed implant arthroplasty. A systematic review of electronic databases to find reports of conversion arthrodesis after failed implant arthroplasty was performed. Six studies involving a total of 76 patients with a weighted mean age of 54.9 met the inclusion criteria. Out of the 6 included articles, the nonunion rate was 16.5% at a weighted mean follow-up of 48.1 months. The nonunion rate in the current report is higher than reported nonunion rates of primary arthrodesis. More prospective studies with consistent and standard outcome measures are needed to further determine the success rate of this salvage procedure. Levels of Evidence: 4, Systematic Review of Level 4 Studies
Does the Number of Screws Influence the Union Rate in Ankle Arthrodesis? A Meta-analysis and Systematic Review
Authors: Izzo Antonio , Sgadari Arianna , Coviello Antonio , Smeraglia Francesco , Balato Giovanni , Mariconda Massimo , Bernasconi Alessio 
Published: May 2023

Objective The purpose of this study was to determine whether the number of cannulated screws used during ankle arthrodesis (AA) might influence the union and complication rate. Methods In this Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compliant PROSPERO-registered systematic review, multiple databases were searched including studies in which patients undergone AA using cannulated screws as exclusive fixation method were followed. Data were harvested regarding the cohort, the study design, the surgical technique, the nonunion, and complication rate at the longest follow-up. Risk of bias was assessed using the modified Coleman Methodology Score (mCMS). Two groups were built (arthrodeses fixed with 2 screws [group 1, G1] vs arthrodeses fixed with 3 screws [group 2 G2]) and compared. Results Fifteen series of patients from 15 studies (667 ankles) were selected (G1 = 458 ankles and G2 = 209). The pooled proportion estimate revealed a similar nonunion rate in the 2-screw group as compared with the 3-screw group (4% vs 3%; P = .68). The pooled proportion of complications was higher in G1 (19%) than in G2 (8%), but it was not significantly different either (P = .45). After exclusion of “symptomatic hardware and screw removal,” the difference was still not significant (P = .28) although it resulted lower in G1 than in G2 (4% vs 8%, respectively). Conclusions Using 3 cannulated screws during AA as compared with a 2-screw construct does not significantly reduce the risk of nonunion nor the risk of complications. Level of Evidence Level IV, Systematic review of level IV
High-dose olanzapine in treatment-resistant schizophrenia: a systematic review
Authors: Gannon Louisa , Reynolds John , Mahon Martin , Gaughran Fiona , Lally John 
Published: May 2023

Background: Treatment-resistant schizophrenia (TRS) affects approximately 30% of people with schizophrenia. Clozapine is the gold standard treatment for TRS but is not always suitable, with a proportion of individuals intolerant of side effects or unable to engage in necessary blood monitoring. Given the profound impact TRS can have on those affected, alternative pharmacological approaches to care are needed. Objectives: To review the literature on the efficacy and tolerability of high-dose olanzapine (>20 mg daily) in adults with TRS. Design: This is a systematic review. Data Sources and Methods: We searched for eligible trials published prior to April 2022 in PubMed/MEDLINE, Scopus and Google Scholar. Ten studies met the inclusion criteria [five randomised controlled trials (RCTs), one randomised crossover trial and four open label studies]. Data were extracted for predefined primary outcomes (efficacy, tolerability). Results: Compared with standard treatment, high-dose olanzapine was non-inferior in four RCTs, three of which used clozapine as the comparator. Clozapine was superior to high-dose olanzapine in a double-blind crossover trial. Open-label studies demonstrated tentative evidence in support of high-dose olanzapine use. It was better tolerated than clozapine and chlorpromazine in two respective RCTs, and was generally well tolerated in open-label studies. Conclusion: This evidence suggests high-dose olanzapine is superior for TRS when compared with other commonly used first- and second-generation antipsychotics, including haloperidol and risperidone. In comparison with clozapine, the data are encouraging for the use of high-dose olanzapine where clozapine use is problematic, but larger, better designed trials are needed to assess the comparative efficacy of both treatments. There is insufficient evidence to consider high-dose olanzapine equivalent to clozapine when clozapine is not contraindicated. Overall, high-dose olanzapine was well tolerated, with no serious side effects. Registration: This systematic review was preregistered with PROSPERO [CRD42022312817].
Assessment of content, behavior change techniques, and quality of unintended pregnancy apps in Spain: Systematic search on app stores
Authors: Martín-Payo Rubén , Gonzalez-Mendez Xana , Carrasco-Santos Sergio , Muñoz-Mancisidor Aranzazu , Papin-Cano Cristina , Fernandez-Alvarez María del Mar 
Published: May 2023

Objective Unintended pregnancies are a public health problem that represents 48% of global pregnancies. Despite the proliferation of smartphones there is limited data on the app's features on unintended pregnancy. The purpose of this research was to identify free apps available in Spanish, in the iOS Store and Google Play, which can be recommended to prevent unintended pregnancies in adolescents. Methods A systematic search to identify apps was performed in the iOS App Store and in Google Play aiming to replicate the way a patient might access an “unintended pregnancy prevention” app. Additionally, the quality, using the Mobile Application Rating Scale, and content were assessed. Results A total of 4614 apps were identified, of which 8 were retrieved for assessment (0.17%). The mean for objective and subject quality was 3.39 (standard deviation (SD) = 0.694) and 1.84 (SD = 0.626), respectively. A total of 16 thematic categories were identified. The mean of topics covered in the apps was 5.38 (SD = 2.925) being those related to contraception the more frequent. Conclusion The results of the present study suggest that only a small percentage of free pregnancy prevention apps in Spanish should be recommended. The contents of the apps retrieved meet the potential necessities of adolescents.
Child Victims’ Interactions with Criminal Justice: An Observational Study in West Bengal
Authors: Dube Dipa , Shaw Rohini Kumari 
Published: May 2023

Crime occurrence has a serious impact on its victims; the toll is even greater when it concerns children. They have to undergo severe physical, psychological and emotional trauma in the aftermath of a crime. When children interact with the criminal justice system, they are put through the gruelling processes of the police investigation, recording statements, medical examination, appearance in courts, cross-examination and so on. Each component has its own impact on the children, with studies suggesting that participation of children in the ‘adult’ criminal justice process can be confusing, distressing and even re-traumatizing. With international efforts to put victims as salient to the criminal justice discourse, things have changed. Recognizing the ineptness of the adult processes in their application towards justice to child victims, States have modified the complexities and attempted to establish a parallel system of justice dispensation that is more ‘child-friendly’. India, on its part, has passed the Protection of Children from Sexual Offences Act, 2012, to redefine the processes in its application to children, especially in matters of child sexual abuse. Thus, special courts are set up, incorporating special measures to ensure the privacy, confidentiality and comfort of the child victims who appear before them. Based on an observational study of ‘special’ and ‘designated’ courts in the State of West Bengal, the present article indicates that Protection of Children from Sexual Offences Act (POCSO Act) directives are still not in place. The insufficient number of fast-track courts, unavailability of dedicated personnel, infrastructural inadequacies and inappropriate processes still mar the justice system. The article forwards suggestions that are imperative to improve the overall experience of child victims.
Understanding patient experience of chronic cough in interstitial lung disease
Authors: Mann Jennifer M.V. , Holland Anne E. , Goh Nicole S.L. , Khor Yet H. 
Published: May 2023

RationaleChronic cough is a common symptom in patients with interstitial lung disease (ILD), negatively contributing to health-related quality of life. Despite this, there is limited information and understanding on the experience of this group of patients with chronic cough. This study aimed to explore the symptom experiences for chronic cough in patients with ILD to identify its characteristics and impacts.MethodsA qualitative study using semi-structured telephone interviews was undertaken in 16 adults with a diagnosis of ILD of any type and severity. Patients were recruited from a quaternary referral centre in Melbourne, Australia. Interviews were transcribed verbatim and coded by two researchers using thematic analysis.ResultsPatients (age range: 39–87 years, forced vital capacity: 53–107% predicted and diffusing capacity of the lung for carbon monoxide: 28–89% predicted) experienced a spectrum of cough severity and characteristics, including both dry and productive coughs. The impact of chronic cough included physical symptoms, social and emotional difficulties, and interference with work and vocational participation. Management strategies used to relieve cough included mucolytics, opiates, throat lozenges, warm drinks, pacing, breath control, relaxation exercises, movement, continuous positive airways pressure and supplemental oxygen. Patients expressed a need for further information and education regarding chronic cough, including its triggers and management.ConclusionsThis study highlights the experience and significance of chronic cough in patients with ILD. The nature and severity of chronic cough in patients with ILD appears to be more heterogeneous than previously described, with physical, social and emotional impacts contributing to symptom burden.
Patients’ acceptance of outcome and experience measurements during hospitalisation for COPD exacerbations: a CICERO Clinical Research Collaboration–European Lung Foundation online patient survey
Authors: Gyselinck Iwein , Ramakrishnan Sanjay , Vermeersch Kristina , Halner Andreas , Pott Hendrik , Dobbels Fabienne , Coleman Courtney , Collis Philip , Watz Henrik , Greulich Timm , Franssen Frits M.E. , Burgel Pierre-Régis , Bafadhel Mona , Janssens Wim ,   on behalf of the CICERO Consortium,   CICERO Clinical Research Collaboration members.Chairs:, Bafadhel Mona , Janssens Wim , Burgel Pierre-Régis , Contoli Marco , Franssen Frits , Greening Neil , Greulich Timm , Huerta Garcia Arturo , Quint Jennifer , Schmeck Bernd , Vanfleteren Lowie , Watz Henrik , Ramakrishnan Sanjay , Gyselinck Iwein , Halner Andreas , McAuley Hamish , Vermeersch Kristina , Beersaerts Amber , Abdo Mustafa , Pott Hendrik , Steven Cass , Albert Richard , Jenkins Christine , Vogelmeier Claus , Collis Philip , Bolsman Hilma , Roche  
Published: May 2023

BackgroundThe lack of standardised outcome assessments during hospitalisation and follow-up for acute COPD exacerbations has hampered scientific progress and clinical proficiency. The objective of the present study was to evaluate patients’ acceptance of selected outcome and experience measurements during hospitalisations for COPD exacerbations and follow-up.MethodsAn online survey was held amongst COPD patients in France, Belgium, The Netherlands, Germany and the UK. The European Lung Foundation COPD Patient Advisory Group was involved in the conceptualisation, development and dissemination of the survey. The survey was complementary to a previously obtained expert consensus. We assessed patients’ views and acceptance of selected patient-reported outcomes or experiences and corresponding measurement instruments (for dyspnoea, frequent productive cough, health status and hospitalisation experience), and of selected clinical investigations (blood draw, pulmonary function test, 6-min walk test, chest computed tomography, echocardiography).Findings200 patients completed the survey. All selected outcomes and experiences were deemed important, and acceptance of their methods of assessment was high. The modified Medical Research Council scale and a numerical rating scale to address dyspnoea, the COPD Assessment Test for quality of life and frequent productive cough, and the Hospital Consumer Assessment of Healthcare Providers and Systems for hospital experiences were the instruments preferred by patients. Consensus on importance of blood draw and spirometry was higher compared with the other investigations.InterpretationThe survey results endorse the use of the selected outcome and experience measurements during hospitalisations for COPD exacerbations. They can be used to optimise standardised and patient-centred care and facilitate multicentric data collection.