bluuebunny/crossref_metadata_2025_split huggingface dataset:
HER2-targeting Peptide Drug Conjugate with Better Penetrability for Effective Breast Cancer Therapy
Authors: Liang Yixia , Lei Rong , Tan Jiabao , Fang Junyue , Yu Lin , Tan Shiyu , Nie Yan , Jiang Qiongchao , Xiao Xiaoyun , Saw Phei Er 
Published: May 2023

Abstract
Antibody-drug conjugates (ADCs) have the following advantages: target specificity; wide therapeutic index; and prolonged circulation half-life. A key limitation of ADCs, however, is the large size (~150 kDa), which markedly slows diffusion through the interstitium of solid tumors and prevents efficient penetration. To address the size issue of ADCs in targeted drug delivery, we developed a HER2-targeting peptide-mertansine conjugate (HER2-TPMC) and conducted a head-to-head comparison with HER2-targeting antibody-mertansine conjugate (HER2-TAMC) as a possible alternative for high-penetration breast cancer therapeutics. As expected, a pharmacokinetic (PK) assay revealed that HER2-TP had lower levels persisting in the circulation after 1 h (~75%) compared to 85% of HER2-targeting antibody (HER2-TA). The cellular cytotoxic effect of HER2-TPMC was similar to HER2-TAMC in the HER2+ BT474 breast cancer cell line, thus demonstrating similar bioactivity of both conjugates. HER2-TPMC not only revealed higher uptake and specificity in in vitro 3D spheroid cultures compared to the parental drug, mertansine, but HER2-TPMC also had a significant retention in the spheroids. This finding was in stark contrast to HER2-TAMC, a large-sized conjugate which was not able to penetrate the spheroid barrier, thus resulting minimal penetration. In vivo tumoral uptake in a BT474 orthotopic model indicated increased tumor uptake and penetration of HER2-TP compared to parental drug and HER2-TAMC. To summarize, we successfully developed a HER2-targeting peptide-mertansine conjugate with specific cellular uptake that resulted in longer retention times in vitro and in vivo. HER2-TPMC (~5 kDa in size) exhibited rapid tissue penetration and enhanced tumoral uptake and retention in vitro and in vivo. Therefore, HER2-TPMC is a reasonable alternative for HER2-positive cancer chemotherapeutics.
Regression from stage 3 to stage 2 type 1 diabetes mellitus after discontinuing growth hormone therapy
Authors: Fischer Micah A , Elmahmudi Ghada A , Goldsweig Bracha K , Elrokhsi Salaheddin H 
Published: May 2023

Summary
Multiple research studies address the anti-insulinemic effect of growth hormone (GH). We report a case of a patient with anterior hypopituitarism on GH replacement who later developed type 1 diabetes mellitus (T1DM). Recombinant human growth hormone (rhGH) therapy was discontinued at the time of growth completion. Because of significantly improved glycemic control, this patient was weaned off subcutaneous insulin. He regressed from stage 3 to stage 2 T1DM and remained in this status for at least 2 years and until the writing of this paper. The diagnosis of T1DM was established based on relatively low C-peptide and insulin levels for the degree of hyperglycemia as well as seropositivity of zinc transporter antibody and islet antigen-2 antibody. Additional laboratory data obtained 2 months after discontinuing rhGH revealed improved endogenous insulin secretion. This case report calls attention to the diabetogenic effect of GH therapy in the setting of T1DM. It also demonstrates the possibility of regression from stage 3 T1DM requiring insulin therapy to stage 2 T1DM with asymptomatic dysglycemia after discontinuing rhGH.

Learning points

Given the diabetogenic effect of growth hormone, blood glucose levels should be monitored in patients with type 1 diabetes mellitus (T1DM) on insulin therapy and recombinant human growth hormone (rhGH) replacement.

Clinicians should closely monitor for risk of hypoglycemia after discontinuing rhGH among T1DM patients who are on insulin treatment.

The discontinuation of rhGH in the setting of T1DM may cause regression of symptomatic T1DM to asymptomatic dysglycemia requiring no insulin treatment.
Técnicas de citología de impresión conjuntival empleadas para el diagnóstico de patologías del segmento anterior: revisión sistemática de literatura
Authors: Atencia Pinzón Omar Alberto , Palencia Flórez Diana Cristina , Peñaloza Silva Mayra Alejandra 
Published: May 2023

Objetivo: Describir los avances de la citología de impresión conjuntival empleada para el análisis morfológico y morfométrico de patologías del segmento anterior, según lo reportado en la literatura en los últimos años, para evidenciar las ventajas de la técnica como prueba diagnóstica confirmatoria. Pregunta PICO: ¿Cuáles son las técnicas de citología de impresión conjuntival empleadas para determinar la presencia de metaplasias y neoplasias conjuntivales que permiten confirmar el diagnóstico de patologías del segmento anterior y la película lagrimal? Metodología: La presente revisión empleó elementos metodológicos propios de la revisión sistemática de literatura. Se consultó en plataformas académicas tales como: Google académico, Scielo, Springer Link, Science Direct, Elsevier, Medline. Así mismo, se acudió a expertos en el tema y a la búsqueda en cadena para rastrear publicaciones y así dar respuesta a la pregunta de investigación. Resultados: Las técnicas de tinción más reportadas para el análisis del tejido conjuntival bulbar fueron: el ácido peryódico de Schiff (PAS) y hematoxilina-eosina. Así mismo, las muestras en su mayoría fueron tomadas con el filtro de acetato de celulosa y los hallazgos se interpretaron según la clasificación de Nelson. Conclusión: La citología de impresión conjuntival (CIC) es una técnica de fácil empleo y eficaz que permite identificar patologías importantes que afectan la superficie ocular como la enfermedad de ojo seco (EOS) y permite evidenciar los cambios en el epitelio ocular dados por enfermedades sistémicas.
Impact of maintenance on domestic wastewater treatment systems
Authors: Györki Gábor , Pálné Szén Orsolya , Knisz Judit 
Published: May 2023

AbstractWastewater treatment systems are important sources of contaminants of emerging substances, including pharmaceuticals, and personal care products. Onsite wastewater treatment systems provide alternative solutions to centralized systems; although they are becoming increasingly popular, little is known about the effect of maintenance on their performance. In the current study, chemical and microbiological parameters in the effluents from two identical on-site wastewater treatment systems were analyzed, one being properly maintained while the other not maintained at all. Taxonomic profiles vastly differed from each other, and organic micropollutants are present at higher concentrations in the effluent of the non-maintained unit. The results highlight the importance of proper maintenance.
ANALISIS BIBLIOMTERIK JURNAL PUSTAKA ILMIAH PERIODE 2016 – 2020
Authors: RAHAYU ROCHANI NANI , SENSUSIYATI SENSUSIYATI 
Published: May 2023

Karakteristik Jurnal Pustaka Ilmiah periode 2016 – 2020, dianalisis menggunakan metode bibliometrik. Adapun tujuan dari analisis tersebut adalah untuk mengetahui: 1). Jumlah artikel yang diterbitkan; 2). Pola kepenulisan; 3) Nilai derajat kolaborasi; 4) Jenis kelamin penulis; 5) Penulis paling produktif; 6) Kata kunci terbanyak. Sumber data yang digunakan adalah Jurnal Pustaka Ilmiah versi online, diakses dari situs ttps://jurnal.uns.ac.id/jurnalpustakailmiah. Adapun data yang dicatat adalah jumlah artikel terbit setiap tahun, nama dan jumlah penulis, jenis kelaminpenulis, tempat bekerja penulis, dan kata kunci. Selanjutnya data diolah menggunakan Exel 2010, dan ditampilkan dalam bentuk tabel yang dilengkapi dengan persentase untuk dilakukan pembahasan, sesuai tujuan penelitian. Kesimpulan penelitian menunjukkan bahwa pada periode 2016 – 2020 Jurnal Pustaka Ilmiah telah menerbitkan sebanyak 104 artikel oleh 121 penulis, yangdidominasi oleh insitusi perguruan tinggi. Universitas Sebelas Maret berada pada posisi teratas, demikian pula untuk penulis paling produktif yaitu Bambang Hermanto dengan tulisan sebanyak 5 judul. Penulis individu lebih banyak dibandingkan dengan penulis yang berkolaborasi yang ditandai dengan nilai derajat kolaborasi sebesar 0,15. Keberadaan Jurnal Pustaka Ilmiah sudahdikenal di lima pulau (Jawa, Sumatera, Sulawesi, Kalimantan, dan Papua) dan pulau Jawa berada di urutan pertama Sebaran kata kunci menunjukkan bahwa artikel yang dimuat terbanyak adalah tentang perpustakaan, pengembangan koleksi dan perpustakaan perguruan tinggi. The characterization of Jurnal Pustaka Ilmiah for the period 2016 – 2020 were analyzed using the bibliometric method. The purpose of the analysis is to find out:1) Number of articles published; 2) The value of the degree of collaboration; 4) The gender of the author; 5) The most keywords. The data source used is the online version of the Scientific Library Journal, accessed from the site https://jurnal.uns.ac.id/jurnalpustakailmiah. The data recorded are the number of articles published eac year, the names and number of authors, the gender of the authors, the keyword. Furthermore, the data is processed using Exel 2010, and displayed in tabular form, equipped with a percentage. Furthermore, a discussion is carried out according to the research objectives. The conclusion ofthe research shows that in the period 2016-2020 the Jurnal Pustaka Ilmiah has published 104 articles by 121 authors, which are dominated by Universities. Sebelas Maret University is in the top position, as well as the most productive writer, Bambang Hermanto with 5 titles. There are more individual writers than collaborating authors, which is indicated by a value of the degree of collaboration of 0.15. Journal is well known in five Islands (Java, Sumatera, Sulawesi, Kalimantan, and Papua) and the Island of Java is the first place. The distribution of keywords shows that the articles published mostly are about libraries, collection development and college libraries.
Variations on Verrition: (Re)turning to the Enigmatic Final Word of Aimé Césaire's Cahier d'un retour au pays natal
Authors: Calhoun Doyle 
Published: May 2023

AbstractBesides the neologism négritude, the term verrition, a hapax legomenon and the final word of Aimé Césaire's celebrated long poem Cahier d'un retour au pays natal (1939–56), is perhaps the most contested and ambiguous signifier in the poet's corpus. This essay reconsiders the much-debated question of verrition and its poiesis. Contra a long-standing tenet of Césaire criticism—that verrition was a pure neologism—and further to René Hénane (Glossaire des termes rares [2004]) and Carrie Noland (Voices of Negritude [2015]), I identify several textual antecedents to and possible sources of this supposed neologism that have implications for how we read the final stanza of the Cahier. Critical focus on Césairean neology has had a somewhat obfuscatory effect on thinking through subtler dimensions of Césaire's decolonial poetics, especially how the poet frequently reinvests and rearticulates existing terms in French, redirecting them toward antiracist and anticolonial ends.
Intimate Editing: The Textual Poetics of Susan Howe's Collage Poems
Authors: Thompson Anne Marie 
Published: May 2023

AbstractSusan Howe's recent collage poems—an intricate, sui generis form—are the flowering of her editorial theory, which I describe as “intimate editing.” I challenge scholarly assumptions that sideline Howe's engagement with the field of textual criticism from accounts of her poetry by showing how her unique approach to texts puts avant-garde poetry and textual editing into conversation, introducing reciprocal possibilities for both. Poems can model new forms of editing, and editorial debates can expand the reach and resonance of innovative poetry. Drawing on The Birth-mark, Howe's collection of creative-critical essays that probe the motivations and ethos of textual criticism, I show how intimate editing expands the typical, often rigid, values of traditional editing and contributes to growing discussions about what a feminist textual criticism might look like. Then I discuss the collage poems, particularly those in Concordance, as whimsical manifestations of Howe's textual approach.
SELECTION OF THE OPTIMAL HEATING COOLANT FOR ARM DEPENDING ON THE TECHNICAL CONDITIONS OF THE OIL AND GAS ENTERPRISE
Authors: Baikov I. R. , Burdygina V. E. , Dunyushkin G. K. 
Published: May 2023

Generation of cold is great demand process for many enterprises of the oil and gas industry. With large capacities of the enterprise, deeper cooling of heat carriers is required in chemical and petrochemical industries, metallurgy, compressor stations, etc. In administrative buildings and workshops located on the sites, it is required to create comfortable conditions in the buildings for the people who are there. In this regard, the demand for refrigeration units is increasing. Until recently, steam compression refrigerating machines were the market leader in refrigeration units. However, their main disadvantage is the high consumption of electricity, and often the process of generating cold has become too expensive.Relatively recently, steam compression refrigerating machines (chillers) have been replaced by absorption refrigerating machines (ARM). Their main and key feature is that they generate cold without consuming a single kilowatt of electrical energy, since the process of generating cold is based on the thermophysical properties of low-boiling solutions of lithium bromide or ammonia.
Explicit Teaching of Socio-Affective Language Learning Strategies to Beginner EFL Students
Authors: Fandiño Parra Yamith José 
Published: May 2023

The objective of this paper is to explicitly teach socio-affective language learning strategies (SLLS) to positively impact the beliefs, attitudes, anxie­ties, and motivations of a group of beginner EFL students at the Centro Colombo Americano in Bogota (Colombia). Therefore, an action research study was carried out with 17 students who were taking a Basic English cour­se. They answered two open-ended questionnaires, one at the beginning and the other at the end of the study; they also answered questions using a rating scale about affective factors and participated in a set of socio-affective acti­vities designed and implemented by the researcher. As a result of the study, an explicit strategy instruction in SLLS is helpful in heightening learner awareness of the importance of paying attention to their own feelings and social relationships as part of their learning process. Thus affective factors are important considerations that both teachers and students need to reflect on to gain a deeper understanding of the nature of language learning and, ultimately, to gain insight about themselves.
Received: 10-08-09 / Accepted: 04-12-09
How to reference this article:
Fandino Parra, Y. J. (2010). Explicit Teaching of Socio-Affective Language Learning Strategies to Beginner EFL Students. Íkala. 15(1), pp.145-169
Contrastive Socioterminology Analysis: The Case of Julakan and French of Health
Authors: Hien Amélie 
Published: May 2023

Up to now, Julakan -unlike French- fails to ensure efficiently and accu­rately transmission of ideas and knowledge in the field of health, even if the concern is sometimes diseases that exist in the environment where this language is used. The aim of this article is to contribute to the enrichment of the Julakan, or at least to stimulate this enrichment which would help this language become an effective means of communication and knowled­ge transfer. The method was a contrastive analysis of the nomenclature of the Julakan language used in the field of traditional medicine with the one utilized in the French language in the domain of modern medicine. The comparison made shows that even though there are instances of equivalence between the concepts of these two languages, there are also situations where quasi-equivalence and terminological gaps can cause problems at the level of communication and health care services. Faced with this reality, this arti­cle suggests specific solutions for each identified critical cases. In addition, new terms are proposed in order to fill terminological gaps and to enrich the nomenclature of the Julakan in the health domain.
Received: 03-03-10 / Accepted: 30-04-10
How to reference this article:Hien, A. (2010). Analyse socioterminologique contrastive: cas du julakan et du français de la santé. Íkala, 15(2), 43 – 72.
An Enhanced Automated Epileptic Seizure Detection Using ANFIS, FFA and EPSO Algorithms
Authors: Mohapatra Sumant Kumar , Patnaik Srikanta , Kumar Mohapatra Sumant 
Published: May 2023

Objectives: Electroencephalogram (EEG) signal gives a viable perception about the neurological action of the human brain that aids the detection of epilepsy. The objective of this study is to build an accurate automated hybrid model for epileptic seizure detection. Methods: This work develops a computer-aided diagnosis (CAD) machine learning model which can spontaneously classify pre-ictal and ictal EEG signals. In the proposed method two most effective nature inspired algorithms, Firefly algorithm (FFA) and Efficient Particle Swarm Optimization (EPSO) are used to determine the optimum parameters of Adaptive Neuro Fuzzy Inference System (ANFIS) network. Results: Compared to the FFA and EPSO algorithm separately, the composite (ANFIS+FFA+EPSO) optimization algorithm outperforms in all respects. The proposed technique achieved accuracy, specificity, and sensitivity of 99.87%, 98.71% and 100% respectively. Conclusion: The ANFIS-FFA-EPSO method is able to enhance the seizure detection outcomes for demand forecast in hospital.
Interpolation of Low-Resolution Images for Improved Accuracy Using an ANN Quadratic Interpolator
Authors: Earshia V. Diana , M. Sumathi 
Published: May 2023

The era of digital imaging has transitioned into a new one. Conversion to real-time, high-resolution images is considered vital. Interpolation is employed in order to increase the number of pixels per image, thereby enhancing spatial resolution. Interpolation's real advantage is that it can be deployed on user end devices. Despite raising the number of pixels per inch to enhances the spatial resolution, it may not improve the image's clarity, hence diminishing its quality. This strategy is designed to increase image quality by enhancing image sharpness and spatial resolution simultaneously. Proposed is an Artificial Neural Network (ANN) Quadratic Interpolator for interpolating 3-D images. This method applies Lagrange interpolating polynomial and Lagrange interpolating basis function to the parameter space using a deep neural network. The degree of the polynomial is determined by the frequency of gradient orientation events within the region of interest. By manipulating interpolation coefficients, images can be upscaled and enhanced. By mapping between low- and high-resolution images, the ANN quadratic interpolator optimizes the loss function. ANN Quadratic interpolator does a good work of reducing the amount of image artefacts that occur during the process of interpolation. The weights of the proposed ANN Quadratic interpolator are seeded by transfer learning, and the layers are trained, validated, and evaluated using a standard dataset. The proposed method outperforms a variety of cutting-edge picture interpolation algorithms..
Модель пошуку співтовариств в соціальній мережі
Authors: Ахрамович Володимир Миколайович , Лазаренко Сергій Володимирович , Мартинюк Ганна Вадимівна , Баланюк Юрій Вікторович 
Published: May 2023

Анотація. З метою забезпечення безперебійного функціонування соціальної мережі з великою кількістю абонентів її доцільно поділити на підмережі. Поділ на підмережі забезпечить якісний контроль трафіку та інших параметрів, у тому числі параметрів безпеки. Перша причина розбиття мережі на підмережі полягає в тому, щоб не отримати величезний broadcast домен. Другою важливою причиною поділу мережі на підмережі є забезпечення певного рівня безпеки. Третя причина – виявлення співтовариств у мережі. Визначено необхідність створення моделі, в якій граф генерується випадковим чином із заданими параметрами для внутрішніх і зовнішніх зв'язків між вершинами, а спільноти покладаються непересічними. Запропоновано метод виділення структури спільнот на основі методу максимальної правдоподібності, і на його основі описано чисельний алгоритм випадкового пошуку. Графи, що представляють реальні соціальні та комунікаційні мережі, швидко змінюються, при цьому ефективним інструментом їх вивчення являються випадкові графи. Важливим завданням є виявлення структури спільнот в мережах. В умовах великої розмірності мереж особливо актуальними є наближені методи, які дозволяють за обмежений час знаходити рішення, близьке до оптимального. Для вирішення такої проблеми пропонується створення моделі виділення структури спільнот на основі методу максимальної правдоподібності, і на його основі опис чисельного алгоритму випадкового пошуку таких спільнот. Досліджено поведінку цільової функції.
Когнітивна модель для дослідження рівня захищеності об’єкта критичної інфраструктури
Authors: Салієва Ольга Володимирівна , Яремчук Юрій Євгенович 
Published: May 2023

Для вирішення питань щодо забезпечення захищеності об’єктів критичної інфраструктури необхідно проаналізувати потенційні загрози, дослідити взаємозв’язки між ними та визначити вплив даних загроз на досліджувану систему. При цьому з’являються деякі труднощі пов’язані із високим ступенем невизначеності, складністю строгої формалізації та суб’єктивним характером даних задач. У зв’язку з цим у роботі пропонується використання когнітивного підходу, який не потребує великого обсягу експериментальних даних, надає можливість опрацьовувати доступну експерту інформацію та враховувати як якісні так і кількісні фактори. На основі даного підходу було створено когнітивну модель, яка базуються на нечіткій когнітивній карті та дозволяє дослідити вплив потенційних загроз на рівень захищеності об’єкта критичної інфраструктури. Здійснено оцінювання структурно-топологічних властивостей нечіткої когнітивної карти, визначено її щільність, індекс ієрархії та центральність концептів. Із сформованої експертним шляхом множини концептів виділено найбільш вагомі. Проведено сценарне моделювання впливу даних концептів на захищеність об’єкта критичної інфраструктури. Дані отримані у результаті запуску відповідних сценаріїв дозволяють дослідити відносну зміну досліджуваної системи та сприяють ефективному вирішенню питань щодо підвищення рівня захищеності об’єктів критичної інфраструктури.