bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecological Approach to the Performance of Larping
Authors: Lampo Marjukka 
Published: May 2023

This paper introduces an ecological approach to the performance of live action role-playing, commonly referred to as larping. Ecology and ecological, in this context, are not used to explain our relation to nature and its protection, but rather our relationship to our surrounding environment and other subjects dwelling in it. The approach was chosen because it provides the study with a comprehensive and an inclusive way of looking at performances.
Larps can be seen as performances from many points of view: it can mean displaying one’s skills in role-playing or in improvising; it can mean patterning one’s behavior to signify that of a fictional character; or it can mean keeping up a vision or expectations of a fictional character. In addition – and what is especially the focus of this paper – the performance of larping can be understood as completing or carrying out actions that constitute the activity called larping.
To explain the ecological approach, this paper will first provide the reader with an overview of larps as ecologies, and then dissect the performance of larping into four steps that are essentially connected to each other in the ecology: information pickup, extraction of possibilities, choice-making and embodiment. To summarize, a larp ecology is a comprehensive interdependent systems where all the players and other organic and non-organic components of the game support each other. In this ecology, the players pick up information, extract possibilities for actions from that information, make choices on which possibilities to carry out and embody those choices by applying their bodily repertoire to the performance.
Implementasi Model Pembelajaran VCT (Value Clarification Technique) Dengan Metode Bermain Peran Pada Mata Kuliah Pengembangan Materi IPS Untuk Penguatan Ranah Afektif Mahasiswa
Authors: Fimansyah Wira 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui bagaimana penerapan dan kelebihan dari Model VCT (Value clarification technique) yang dipadukan dengan metode bermain peran sehingga berguna untuk penguatan ranah afektif mahasiswa. Penelitian ini adalah kualitatif deskriptif. Tekhnik pengumpulan data dengan cara observasi, wawancara mendalam dan dokumentasi. Data yang telah terkumpul kemudian diolah dengan model interaktif Miles & Huberman dengan 4 tahap yaitu pengumpulan data, reduksi data, penyajian data dan menarik kesimpulan. Temuan menunjukkan bahwa penerapan model pembelajaran VCT (Value clarification technique) yang dipadukan dengan metode bermain peran efektif dalam memberikan penguatan terhadap ranah afektif mahasiswa. Dengan beberapa kelebihan yakni dapat memberikan kesadaran akan nilai dan norma social yang berkembang dalam masyarakat, mahasiswa jadi lebih berani mengambil keputusan jika dihadapkan dalam situasi tertentu sehingga bisa menjadi problem solver, mahasiswa merasa jauh lebih kreatif dan inovatif, dapat meningkatkan kerjasama antar anggota kelompok sehingga solidaritas mereka meningkat, mahasiswa juga bisa memilih nilai mana yang paling tepat diaplikasikan dalam kehidupan sehari-hari setelah diperkuat dengan penampilan sosiodrama.
Effect of Weather Dynamics to Energy Yield of Dual Axis Sun Tracker-Based Solar PV generation
Authors: Hasyim Rosma Iswadi , Rinaldi Dicky , Sukma Dian Yayan 
Published: May 2023

Generally, solar PV Panel is constructed at fix tilted angle at different locations, such as: street light poles, rooftops, residential buildings, and canopy. The energy production from solar PV generation system is vary and influenced by site (location) and weather parameters. Solar PV generation analyzed in this research is Dual Axis Sun Tracker (DAST) Solar PV Generation. Dual axis sun tracker is a system controller to ensure solar PV panel following the sun path. Furthermore, energy production from DAST-based solar PV generation were measured and collected using energy meter as well as by using automatic weather station for the weather parameters. From these measrument data, it can be correlated the influence of weather parameters to the energy production from DAST PV generation system. The correlation between weather parameters and energy production are analyzed by statistical analysis using SPSS software and multiple linear regression models. From the results and analysis, it can be shown the amount of energy production from DAST-based solar PV Generation are influenced by weather parameters, namely: temperature, humidity, ultraviolet radiation, and solar radiation with significant level up to 98.2%.
Effect of Pulse Width Modulation on Proportional, Integral, and Derivative Coefficient Characteristics
Authors: Suhendra Tonny 
Published: May 2023

Based on the value of feedback obtained from the sensor (LDR), the PID algorithm uses the error value obtained from the comparison between the sensor value and the setpoint value to perform calculations so that the PWM generator will use the output value to produce a row of pulses that will be converted to a voltage (signal) with a range of 0 to 255 (0 volt to 5 volt) and is used to turn on the LED lamp according to the desired light level. The output characteristics generated by the PID control for each coefficient can be used as a benchmark to determine the correct coefficient value for Propotional coefficient, Integral coefficient and Derivative coefficient as a whole. From the test results, it can be seen that the coefficient value adjustment can be taken based on the size of the difference or error contained in the system. If the difference in error is slight, the use of large coefficient values, especially in derivative coefficients. It helps the system achieve a stable condition and reduces overshoot. Still, if the error value is significant, then applying a considerable efficiency value will make the system achieve stable condition stable becomes a little tricky because it is possible to overshoot the PID output.
Konstruksi Model Sosialisasi Hukum Berbasis Kearifan Lokal Kepada Yayasan Penyelenggara Pendidikan Dalam Penyesuaian Anggaran Dasar
Authors: Bahmid  , Sidabalok Hamidah , Sartika Dewi , Dewi Renita , Anisa Heni Nasution Rifqah 
Published: May 2023

Ketidakpatuhan organ yayasan pendidikan di Kabupaten Asahan terhadap perintah penyesuaian anggaran dasar bagi yayasan yang telah ada sebelum lahirnya Undang-Undang Nomor 28 Tahun 2004 tentang perubahan atas Undang Undang Nomor 16 Tahun 2001 tentang Yayasan. Hal ini disebabkan karena tidak sesuai dengan kearifan lokal yang ada di Kabupaten Asahan. Oleh karena itu, penting dilakukan penelitian mengenai pengarahan kepatuhan hukum dalam bentuk sosialisasi terkait problem yang ada yang dihubungkan dengan kearifan lokal. Metode penelitian yang digunakan adalah yuridis empiris dengan pendekatan efektivitas. Dari hasil penelitian, menunjukkan bahwa sosialisasi berkearifan lokal ini sangat efektif dalam memberikan penafsiran kepada masyarakat. Hal ini disebabkan para organ yayasan paham mengapa penting dilakukannya penyesuaian anggaran dasar.
Nasal immunization with H7 flagellin protects mice against hemolytic uremic syndrome secondary to Escherichia coli O157:H7 gastrointestinal infection
Authors: Bernal Alan Mauro , Sosa Fernando Nicolás , Todero María Florencia , Montagna Daniela Romina , Vermeulen Mónica Elba , Fernández-Brando Romina Jimena , Ramos María Victoria , Errea Agustina Juliana , Rumbo Martin , Palermo Marina Sandra 
Published: May 2023

IntroductionShiga-toxin (Stx) producing Escherichia coli (STEC) O157:H7 is the most frequent serotype associated with hemolytic uremic syndrome (HUS) after gastrointestinal infections. Protection against HUS secondary to STEC infections has been experimentally assayed through the generation of different vaccine formulations. With focus on patients, the strategies have been mainly oriented to inhibit production of Stx or its neutralization. However, few approaches have been intended to block gastrointestinal phase of this disease, which is considered the first step in the pathogenic cascade of HUS. The aim of this work was to assay H7 flagellin as a mucosal vaccine candidate to prevent the systemic complications secondary to E. coli O157:H7 infections.Materials and methodsThe cellular and humoral immune response after H7 nasal immunization in mice were studied by the analysis of systemic and intestinal specific antibody production, as well as cytokine production and lymphocyte proliferation against H7 flagellin ex vivo.ResultsImmunized mice developed a strong and specific anti-H7 IgG and IgA response, at systemic and mucosal level, as well as a cellular Th1/Th2/Th17 response. H7 induced activation of bone marrow derived dendritic cells in vitro and a significant delayed-type hypersensitivity (DTH) response in immunized mice. Most relevant, immunized mice were completely protected against the challenge with an E. coli O157:H7 virulent strain in vivo, and surviving mice presented high titres of anti-H7 and Stx antibodies.DiscussionThese results suggest that immunization avoids HUS outcome and allows to elicit a specific immune response against other virulence factors.
A third dose of the BNT162b2 mRNA vaccine sufficiently improves the neutralizing activity against SARS-CoV-2 variants in liver transplant recipients
Authors: Tomiyama Takahiro , Suzuki Rigel , Harada Noboru , Tamura Tomokazu , Toshida Katsuya , Kosai-Fujimoto Yukiko- , Tomino Takahiro , Yoshiya Shohei , Nagao Yoshihiro , Takeishi Kazuki , Itoh Shinji , Kobayashi Nobuhiro , Ito Hayato , Yoshio Sachiyo , Kanto Tatsuya , Yoshizumi Tomoharu , Fukuhara Takasuke 
Published: May 2023

IntroductionWe examined the neutralizing antibody production efficiency of the second and third severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine doses (2nd- and 3rd-dose) and neutralizing activity on mutant strains, including, the Ancestral, Beta and Omicron strains using green fluorescent protein-carrying recombinant SARS-CoV-2, in living-donor liver transplantation (LDLT) recipients.MethodsThe patients who were administered vaccines other than Pfizer- BioNTechBNT162b2 and who had coronavirus disease 2019 in this study period were excluded. We enrolled 154 LDLT recipients and 50 healthy controls.ResultThe median time were 21 days (between 1st and 2nd vaccination) and 244 days (between 2nd and 3rd vaccination). The median neutralizing antibody titer after 2nd-dose was lower in LDLT recipients than in controls (0.46 vs 1.00, P&lt;0.0001). All controls had SARS-CoV-2 neutralizing antibodies, whereas 39 LDLT recipients (25.3%) had no neutralizing antibodies after 2nd-dose; age at vaccination, presence of ascites, multiple immunosuppressive treatments, and mycophenolate mofetil treatment were significant risk factors for nonresponder. The neutralizing activities of recipient sera were approximately 3-fold and 5-fold lower than those of control sera against the Ancestral and Beta strains, respectively. The median antibody titer after 3rd-dose was not significantly different between recipients and controls (1.02 vs 1.22, p=0.0758); only 5% recipients was non-responder. The neutralizing activity after third dose to Omicron strains were enhanced and had no significant difference between two groups.ConclusionOnly the 2nd-dose was not sufficiently effective in recipients; however, 3rd-dose had sufficient neutralizing activity against the mutant strain and was as effective as that in healthy controls.
Aflibercept for long-term treatment of diabetic macular edema and proliferative diabetic retinopathy: a meta-analysis
Authors: Xie Xiao , Lian Chao , Zhang Zhiping , Feng Meng , Wang Wenqi , Yuan Xiaomeng , Shi Yanmei , Liu Tingting 
Published: May 2023

PurposeThis meta-analysis compared the long-term (12 months or 24 months) efficacy and safety of intravitreal aflibercept injection (IAI) for diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR).MethodsWe selected 16 randomized controlled trials (RCTs) performed after 2015 that had a minimum of 12 months and up to 24 months of treatment and conducted a meta-analysis with Review Manager version 5.3. Visual acuity (VA), central subfield thickness (CST) and adverse events were the outcomes selected for evaluation from the eligible studies.ResultsBased on 16 RCTs, we evaluated a total of 7125 patients. For PDR and severe DME with poor baseline vision, after a minimum of 12 months and up to 24 months of treatment, the aflibercept treatment group obtained better VA improvement than the focal/grid laser photocoagulation treatment group (MD=13.30; 95%CI: 13.01~13.58; P&lt;0.001) or other treatments (ranibizumab, focal/grid laser photocoagulation, PRP, et al.) group (MD=1.10; 95%CI: 1.05~1.16; P&lt;0.001). In addition, the aflibercept treatment group got higher CST reduction than the focal/grid laser photocoagulation treatment (MD=-33.76; 95%CI: -45.53 ~ -21.99; P&lt;0.001) or other treatments (ranibizumab, focal/grid laser photocoagulation, et al.) group (MD=-33.76; 95%CI: -45.53 ~ -21.99; P&lt;0.001). There was no significant difference in the overall incidence of ocular and non-ocular adverse events in each treatment group.ConclusionsThis meta-analysis showed that the advantages of IAI are obvious in the management of DME and PDR with poor baseline vision for long-term observation (a minimum of 12 months and up to 24 months) with both VA improvement and CST reduction. Applied IAI separately trended to be more effective than panretinal photocoagulation separately in VA improvement for PDR. More parameters should be required to assess functional and anatomic outcomes.
Asthma prevalence is increased in patients with high metabolism scores for visceral fat: study reports from the US
Authors: Liu Qiushi , Han Xiaoxiao , Chen Yan , Gao Ying , Yang Wei , Huang Lewei 
Published: May 2023

ObjectiveData from NHANES 2001-2018 were used to examine the relationship between metabolism score for visceral fat (METS-VF) and asthma prevalence.MethodsWe assessed the association between METS-VF and asthma disease using multiple logistic regression analysis from the National Health and Nutrition Examination Survey (NHANES), 2001-2018, followed by subgroup analysis for sensitive populations. To determine whether METS-VF and asthma disease had a non-linear relationship, smooth curve fitting was used, and threshold effect analysis was used to verify the relationship.ResultsAmong the 36,876 participants, 4,919 self-reported having asthma. When all confounders were controlled for, a positive association was found between METS-VF and asthma prevalence (OR = 1.27, 95% CI: 1.22,1.32), and this positive association was stronger with elevated METS-VF (P for trend = 0.01). According to the smooth curve fitting analysis, METS-VF and asthma prevalence do not have a linear relationship. The double-segmented threshold effect analysis suggested a negative correlation but no statistically significant difference between METS-VF less than 5.24 and asthma prevalence (OR = 0.60, 95% CI: 0.33, 0.91). Besides, other METS-VF showed positive associations with asthma prevalence before and after the effective inflection point. According to subgroup analysis, METS-VF is associated with asthma prevalence among participants aged 40 – 59, male, Mexican American, with hypertension and diabetes, and without asthma history.ConclusionA positive correlation between METS-VF and asthma was observed and this positive correlation was non-linear, and participants with METS-VF above 5.24 should be cautious about the high risk of asthma. The relationship should be given more attention to participants who are aged 40-59 years old, male, Mexican American, have hypertension, diabetes, and who do not have a family history of asthma.
Dietary supplementation with Chinese herb ultrafine powder improves intestinal morphology and physical barrier function by altering jejunal microbiota in laying hens
Authors: Gui Jue , Azad Md Abul Kalam , Lin Wenchao , Meng Chengwen , Hu Xin , Cui Yadong , Lan Wei , He Jianhua , Kong Xiangfeng 
Published: May 2023

IntroductionChinese medicinal herbs play important roles in anti-inflammatory, antioxidant, and antibacterial activities. However, the effects of Chinese herb ultrafine powder (CHUP) on laying hens still need to be elucidated. Therefore, this study aimed to evaluate the effects of dietary CHUP supplementation on jejunal morphology, physical barrier function, and microbiota in laying hens.MethodsA total of 576 Xinyang black-feather laying hens (300 days old) were randomly assigned into eight groups, with eight replicates per group and nine hens per replicate. The hens were fed a basal diet (control group) and a basal diet supplemented with 0.5% Leonuri herba (LH group), 0.25% Ligustri lucidi fructus (LF group), 0.25% Taraxaci herba (TH group), 0.5% LH + 0.25% LF (LH-LF group), 0.5% LH + 0.25% TH (LH-TH group), 0.25% LF + 0.25% TH (LF-TH group), and 0.5% LH + 0.25% LF + 0.25% TH (LH-LF-TH group), respectively, for 120 days.ResultsThe results showed that dietary LH-LF and LH-LF-TH supplementation increased (p &lt; 0.05) the jejunal villus height to crypt depth ratio of laying hens. Dietary LF-TH supplementation up-regulated jejunal claudin-5 expression, while LH supplementation up-regulated jejunal claudin-1 expression and increased the jejunal abundances of potentially beneficial bacteria related to short-chain fatty acids and bacteriocins production, such as Blautia, Carnobacterium, Clostridiales, and Erysipelotrichales (p &lt; 0.05). In addition, dietary LH supplementation enriched (p &lt; 0.05) the tetracycline biosynthesis, butirosin/neomycin biosynthesis, and D-arginine/D-ornithine metabolism, whereas steroid biosynthesis and limonene/pinene degradation were enriched (p &lt; 0.05) in the LH-LF and LH-LF-TH groups. Moreover, Spearman’s correlation analysis revealed the potential correlation between the abundance of the jejunal microbiota and jejunal morphology and the physical barrier function of laying hens.DiscussionCollectively, these findings suggest that dietary CHUP supplementation could enhance the beneficial bacteria abundance, physical barrier function, and metabolic function associated with short-chain fatty acids and bacteriocins production. Moreover, combined supplementation of dietary CHUP showed better effects than the sole CHUP supplementation.
The persistence of stress-induced physical inactivity in rats: an investigation of central monoamine neurotransmitters and skeletal muscle oxidative stress
Authors: Buhr Trevor J. , Reed Carter H. , Wee Olivia M. , Lee Ji Heun , Yuan Li-Lian , Fleshner Monika , Valentine Rudy J. , Clark Peter J. 
Published: May 2023

IntroductionSedentary lifestyles have reached epidemic proportions world-wide. A growing body of literature suggests that exposures to adverse experiences (e.g., psychological traumas) are a significant risk factor for the development of physically inactive lifestyles. However, the biological mechanisms linking prior stress exposure and persistent deficits in physical activity engagement remains poorly understood.MethodsThe purpose of this study was twofold. First, to identify acute stress intensity thresholds that elicit long-term wheel running deficits in rats. To that end, young adult male rats were exposed to a single episode of 0, 50, or 100 uncontrollable tail shocks and then given free access to running wheels for 9 weeks. Second, to identify stress-induced changes to central monoamine neurotransmitters and peripheral muscle physiology that may be maladaptive to exercise output. For this study, rats were either exposed to a single episode of uncontrollable tail shocks (stress) or left undisturbed in home cages (unstressed). Eight days later, monoamine-related neurochemicals were quantified by ultra-high performance liquid chromatography (UHPLC) across brain reward, motor, and emotion structures immediately following a bout of graded treadmill exercise controlled for duration and intensity. Additionally, protein markers of oxidative stress, inflammation, and metabolic activity were assessed in the gastrocnemius muscle by Western blot.ResultsFor experiment 1, stress exposure caused a shock number-dependent two to fourfold decrease in wheel running distance across the entire duration of the study. For experiment 2, stress exposure curbed an exercise-induced increase of dopamine (DA) turnover measures in the prefrontal cortex and hippocampus, and augmented serotonin (5HT) turnover in the hypothalamus and remaining cortical area. However, stress exposure also caused several monoaminergic changes independent of exercise that could underlie impaired motivation for physical activity, including a mild dopamine deficiency in the striatal area. Finally, stress potently increased HSP70 and lowered SOD2 protein concentrations in the gastrocnemius muscle, which may indicate prolonged oxidative stress.DiscussionThese data support some of the possible central and peripheral mechanisms by which exposure to adverse experiences may chronically impair physical activity engagement.
Pilot study on 11C-CFT dynamic imaging using total-body PET/CT: biodistribution and radiation dosimetry in Parkinson's disease
Authors: Xin Mei , Li Lianghua , Wang Cheng , Shao Hongda , Liu Jianjun , Zhang Chenpeng 
Published: May 2023

ObjectiveTotal-body PET/CT equipment, uEXPLORER, is a newly developed imaging technology with a superior resolution, high sensitivity, and high signal-to-noise ratio, providing unique application advantages in the pharmacokinetic evaluation of positron tracers. While 11C-CFT PET/CT has been widely utilized in the early diagnosis of Parkinson's disease (PD), it is limited by the short half-life of the radionuclide and an incomplete understanding of its biological distribution in humans. This study aimed to use a total-body PET/CT dynamic scan with 11C-CFT imaging to describe the real-time internal biodistribution in PD patients and to obtain accurate radiation dosimetry.MethodsSix male subjects with suspected PD underwent dynamic 11C-CFT total-body PET/CT. Following a bedside intravenous bolus injection of 373.3 ± 71.56 MBq of 11C-CFT, PET acquisition was performed synchronously for 75 min with a maximum axial field of view (AFOV) of 194 cm. Time-activity curves (TACs) were generated by delineating volumes of interest (VOIs) of the sourced organs using PMOD software. Tracer kinetics and cumulative organ activities were calculated, and absorbed doses were calculated and estimated using the OLINDA/EXM software.ResultsIn the systemic TAC analysis of 11C-CFT, several unique types of distribution patterns were obtained among several major organs, including a “Fast-in Fast-out” pattern in the kidneys, lungs, spleen, and thyroid, a “Fast-in Slow-out” curve in the heart wall, a “Slow-in Slow-out” mode in the liver, a “Low-level extending” pattern in the whole brain and muscle, and a “Slow-in to plateau” trend in the striatum and bone. The effective dose of 11C-CFT was calculated to be 2.83E-03 mSv/MBq, which is only one-third of the literature value measured by the conventional method. Moreover, this dose is much lower compared to all other doses of DAT radioligands used in PET imaging.ConclusionThis study is a pioneering application of total-body PET/CT to 11C-CFT dynamic imaging. Our results confirmed that 11C-CFT has a favorable total body biodistribution, an extremely low internal radiation dose, and high imaging quality, making it suitable for reasonable PD diagnosis in patients requiring multiple follow-up examinations.