bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the Power Output of a Partially Shaded Photovoltaic Array through a Hybrid Magic Square Configuration with Differential Evolution based Adaptive P&O MPPT Method
Authors: Muniyandi Vijay , Saravanan M. , Balasubramanian Ashok Kumar 
Published: January 2023

Abstract
A partially shaded photovoltaic (PV) array's characteristic curve is convoluted due to disparity in irradiance levels between shaded and unshaded PV panels, resulting in power mismatch losses. This work presents a new hybrid approach combining the Magic Square (MS) array configuration and Differential Evolution based adaptive perturb and observe (DEAPO) MPPT methodology to overcome the abovementioned problem. The proposed hybrid methodology is implemented in two steps: first, repositioning the PV panels as per the MS configuration to decrease the power losses of partial shading. In MS configuration, the concentrated shadow on a single row or column can spread over to the entire PV array equally without any physical or electrical switching of PV panels. Second, the DEAPO MPPT method is developed to find the global peak power point on the PV characteristic curve. PID controller coefficients are optimized by DE to enhance the tracking speed and convergence of the adaptive P&O MPPT. The simulation study of this work has been implemented using PV arrays in MATLAB/SIMULINK environment and the real-time validation is done through a 5 kW PV array. The proficiency of the proposed hybrid approach is tested by creating various non-uniform and uniform shading patterns on the PV array. The simulation and experimental results prove that the proposed hybrid approach increases the power output by 19% and 20% higher than the existing Total Cross Tie (TCT) configuration under non-uniform and uniform shading cases respectively.
An Innovative Design for a Solar Water Heating System Utilizing a Flat-Shaped Heat Pipe
Authors: Siritan Methida , Vafai Kambiz , Kammuang-Lue Niti , Terdtoon Pradit , Sakulchangsatjatai Phrut 
Published: January 2023

Abstract
In this work, an innovative design for a solar water heating system using a flat-shaped heat pipe as a heat transfer device is presented to pave the way for a substantial increase in the thermal performance of these systems. An analytical study is utilized to investigate the thermal performance of the solar water heating system. The analytical results of the flat-shaped heat pipe system are compared with the results of the evacuated tube solar water heating system with a U-tube, thermosyphon, and closed-loop pulsating heat pipe. It is found that the water temperature difference between the inlet and outlet of the flat-shaped heat pipe system is substantially higher than the U-tube, thermosyphon, and closed-loop pulsating heat pipe system by as much as 31.4, 22.5, and 18.5 °C, respectively, at a nominal 0.6 l/min mass flowrate. Furthermore, utilizing the flat-shaped heat pipe in the solar water heating system optimizes the thermal conductivity of the solar setup due to a reduction in the condenser section length. These reductions also lead to a large reduction in the weight and cost of the system.
Developmental Progression and Sex Differences in Agility During Continuous Two-Footed Jumping Among Children Aged 4–16 Years
Authors: Muro Ayane , Takatoku Nozomi , Ohtaka Chiaki , Fujiwara Motoko , Nakata Hiroki 
Published: January 2023

We investigated performance levels on conducting continuous two-footed jumping of preschool children (4 years old) to high school students (16 years old) to clarify the developmental progression and sex differences in motor coordination and agility. In total, 450 children (boys: 227; girls: 223) participated in this study. We set 10 obstacles to jump over for continuous two-footed jumping and analyzed the movement time (MT), aerial time (AT), and contact time (CT), and variabilities in AT and CT in 7 year-based categories, using a high-speed camera. We also used multiple regression analysis to identify the predictors of MT. MT and CT shortened until 8 years, whereas AT continued to shorten after 8 years, suggesting that the jumping strategy differs between those younger/older than 8 years. MT, AT, and CT were significantly shorter among boys than girls from preschool children to high school students. In addition, when using multiple regression analysis, the main predictor of MT changed gradually from SD of CT to AT with increasing age. Our findings suggest that the motor control mechanisms related to continuous two-footed jumping differ depending on the age and sex and provide findings to advance understanding of the age-related motor coordination and agility in children.
Exploring gaps and opportunities in primary care following an asthma hospital admission: a multisite mixed-methods study of three data sources
Authors: Jones Renee , Hiscock Harriet , Shanthikumar Shivanthan , Lei Shaoke , Sanci Lena , Chen Katherine 
Published: January 2023

ObjectiveExplore gaps and opportunities in primary care for children following a hospital admission for asthma.DesignExploratory mixed-methods, using linked hospital and primary care administration data.SettingEligible children, aged 3–18 years, admitted to one of three hospitals in Victoria, Australia between 2017 and 2018 with a clinical diagnosis of asthma.Results767 caregivers of eligible children participated, 39 caregivers completed a semistructured interview and 277 general practitioners (GPs) caring for 360 children completed a survey. Over 90% (n=706) of caregivers reported their child had a regular GP. However, few (14.1%, n=108) attended a GP in the 24 hours prior to index admission or in the 7 days after (35.8%, n=275). Children readmitted for asthma (34.2%, n=263), compared with those not readmitted (65.8%, n=504), were less likely to have visited a GP in the non-acute phase of their asthma in the 12 months after index admission (22.1% vs 42.1%, respectively), and their GP was more likely to report not knowing the child had an asthma admission (52.8% vs 39.2%, respectively). Fewer GPs reported being extremely confident managing children with poorly controlled asthma (11.9%, n=43) or post-discharge (16.7%, n=60), compared with children with well-controlled asthma (36.4%, n=131), with no difference by child readmission status.ConclusionsGiven the exploratory design and descriptive approach, it is unknown if the differences by child readmission status have any causal relationship with readmission. Nonetheless, improving preventative patterns of primary care visits, timely communication between hospitals and primary care providers, and guideline concordant care by GPs are needed.
National consensus to develop core outcomes for the evaluation of complications from excess weight (CEW) clinics: results of a national Delphi process
Authors: Stilwell Philippa Anna , White Billy , Graham Catherine , Rigby Emma , Shield Julian P H , Brandreth Rachael , Solti Sophie , Owen Richard , Kenny Simon 
Published: January 2023

ObjectiveIn 2021, centres across all seven NHS-England regions were selected to develop pilot clinics with the aim of treating children and young people (CYP) living with complications relating to excess weight (CEW). We led a process to develop core outcomes to enable the evaluation of these clinics.MethodsA two-round Delphi process, virtual steering group meetings and two patient representation workshops were used to agree the most important outcomes for both clinicians/allied professionals and representative prospective service users.ResultsA total of 119 clinicians/allied professionals were invited to contribute to the Delphi process: 62 (52%) agreed and completed round 1 and 47 of these (76%) went on to complete round 2. Six young people (age range 13–17 years) and six parents were involved in two patient representation workshops and their experiences fed into virtual steering group meetings, via a representative.There were 44 outcomes assessed in round 1 and 21 outcomes assessed in round 2. There were 16 core outcomes selected: anthropometric, glucose tolerance/insulin resistance/type 2 diabetes, blood pressure, lipid profile, breathing problems, identification of aetiology, non-alcoholic fatty liver disease, idiopathic intracranial hypertension, anxiety, depression, self-esteem, quality of life, school attendance, dietary habits including disordered eating, exercise and activity habits.ConclusionsUse of an online Delphi process, patient representation workshops and virtual steering group meetings has enabled the development of core outcomes for clinical obesity services with eight physical health, five mental health and three self-management outcomes. Further work is needed to develop outcome measures to complete a core outcome set. These will be used to guide the evaluation of novel regional clinics for the treatment of complications of excess weight.
Supersymmetrization of deformed BMS algebras
Authors: Banerjee Nabamita , Mitra Arpita , Mukherjee Debangshu , Safari H. R. 
Published: January 2023

AbstractThe W(a, b) and $$W(a,b;\bar{a},\bar{b})$$

W
(
a
,
b
;

a

¯

,

b

¯

)

algebras are deformations of $$\mathfrak {bms}_{3}$$

bms
3

and $$\mathfrak {bms}_{4}$$

bms
4

algebras, respectively. We present a $$\mathcal {N}=2$$

N
=
2

supersymmetric extension of both algebras in the presence of Rsymmetry generators that rotates the two supercharges. Our construction provides the most generic central extensions of the W(a, b) algebra. In particular, we find that $$\mathcal {N}=2$$

N
=
2

$$\mathfrak {bms}_{3}$$

bms
3

algebra admits a new central extension. On the other hand, we explicitly demonstrate that an infinite $$U(1)_V \times U(1)_A$$

U

(
1
)

V

×
U

(
1
)

A

extension of the $$W(a,b;\bar{a},\bar{b})$$

W
(
a
,
b
;

a

¯

,

b

¯

)

algebra corresponding to the $$R-$$

R
-

symmetry is not possible for linear and quadratic structure constants with generic deformation parameters. This also implies that the infinite R symmetry considered in our analysis is broken for the $$\mathcal {N}=2 \, \mathfrak {bms}_{4}$$

N
=
2

bms
4

algebra.
Gravitational waves from no-scale supergravity
Authors: Spanos Vassilis C. , Stamou Ioanna D. 
Published: January 2023

AbstractIn this paper we study four concrete models, based on no-scale supergravity with SU(2,1)/SU(2) $$\times $$
×
U(1) symmetry. We modify either the Kähler potential or the superpotential, which are related to the no-scale theory with this symmetry. In this scenario, the induced Gravitational Waves, are calculated to be detectable by the future space-based observations such as LISA, BBO and DECIGO. The models under study are interrelated, as they all yield the Starobinsky effective-like scalar potential in the unmodified case. We evaluate numerically the scalar power spectrum and the stochastic background of the Gravitational Waves, satisfying the observational Planck cosmological constraints for inflation.
Loss of CDKN2A Cooperates with WWTR1(TAZ)–CAMTA1 Gene Fusion to Promote Tumor Progression in Epithelioid Hemangioendothelioma
Authors: Seavey Caleb N. , Hallett Andrea , Li Shuo , Che Kepeng , Pobbati Ajaybabu V. , Ma Shuang , Burtscher Ashley , Kanai Ryan , Lamar John M. , Rubin Brian P. 
Published: January 2023

Abstract

Purpose:
Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma caused by the WWTR1(TAZ)–CAMTA1 (TC) gene fusion. This fusion gene has been observed in almost all reported EHE cases and functions as a constitutively activated TAZ. Sequencing of human tumors has, however, identified additional secondary mutations in approximately 50% of EHE, most commonly the loss of tumor suppressor CDKN2A. In this study, the effect of loss of CDKN2A in EHE tumorigenesis was evaluated.

Experimental Design:
Mice bearing a conditional TC allele were paired with a conditional Cdkn2a knockout allele and an endothelial-specific Cre. Histologic characterization and single-cell RNA-seq of the resultant tumors were performed. EHE cell lines were established through ex vivo culture of tumor cells and evaluated for sensitivity to TEAD inhibition and trametinib.

Results:
Loss of Cdkn2a within EHE was associated with more aggressive disease, as displayed by earlier tumor-related morbidity/mortality and enhanced tumor cell proliferation. As no previous EHE cell lines exist, we attempted, successfully, to expand EHE tumor cells ex vivo and produced the first EHE cell lines. These cell lines are “addicted” to the TC oncoprotein, replicate the EHE transcriptional profile, and generate EHE tumors when injected into immunodeficient mice.

Conclusions:
CDKN2A loss enhances the tumorigenicity of EHE in vivo and enabled the generation of the first cell lines of this disease. These cell lines replicate key facets of the human disease phenotype. Therefore, these cell lines and allograft tumors generated after implantation serve as robust model systems for therapeutic testing of compounds directed at either EHE or other TAZ-driven cancers.
Abstract P013: Impact of blood-based biomarkers for predicting lung cancer mortality in the PLCO cohort
Authors: Irajizad Ehsan , Fahrmann Johannes F. , Vykoukal Jody V. , Dennison Jennifer B. , Long James P. , Do Kim-Anh , Ostrin Edwin J. , Hanash Sam 
Published: January 2023

Abstract
Purpose: To investigate the utility of integrating a panel of circulating protein biomarkers in combination with a risk model based on subject characteristics for identifying individuals at high risk of harboring a lethal lung cancer. Methods: Data for a 4-marker protein panel (4MP) (consisting of the precursor form of surfactant protein B, cancer antigen 125, carcinoembryonic antigen, and cytokeratin-19 fragment) previously assayed in pre-diagnostic sera from 552 lung cancer cases and 2,193 non-cases from the Prostate Lung Colorectal and Ovarian (PLCO) cohort as well as a scores from a logistic regression model that combined the 4MP with the PLCOm2012 risk model were used for this study. Of the 552 lung cancer cases, 387 (70%) died from lung cancer. Cumulative incidence of lung cancer death as well as sub-distributional and cause-specific hazard ratios were calculated based on 4MP+PLCOm2012 risk scores at a pre-defined 1.0%/6-year risk threshold, which corresponds to current US Preventive Services Task Force screening criteria. For hazard modeling, stage at the time of clinical diagnosis and treatment modality were considered as co-variables. Results: When considering cases diagnosed within 1 year of blood draw and all non-cases, the performance estimate of the 4MP+PLCOm2012 model for risk prediction of lung cancer death was 0.88 (95% CI: 0.86-0.90). Among cases only, at the 1.0%/6-year risk threshold the cumulative incidence of lung cancer death was statistically significantly higher in ‘test positive’ cases compared to ‘test negative’ cases (Chi-square test: 5.42, P: 0.02). The adjusted sub distributional hazard ratio for ‘test positive’ cases was 1.67 (95% CI: 1.02-2.74). The adjusted lung-cancer death-specific hazard ratio for ‘test positive’ cases was 2.02 (95% CI: 1.28-3.17). Conclusions and Relevance: The blood-based biomarker panel in combination with PLCOm2012 identifies individuals at high risk of a lethal lung cancer.
Citation Format: Ehsan Irajizad, Johannes F. Fahrmann, Jody V. Vykoukal, Jennifer B. Dennison, James P. Long, Kim-Anh Do, Edwin J. Ostrin, Sam Hanash. Impact of blood-based biomarkers for predicting lung cancer mortality in the PLCO cohort. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr P013.
Abstract P019: Continued depression of breast and lung cancer screening among Medicare enrollees during the COVID-19 pandemic
Authors: Doan Christopher Huy D. , Li Shuang , Goodwin James 
Published: January 2023

Abstract
Background: Several studies reported sharp decreases in screening mammography for breast cancer and low-dose computerized tomographic screening for lung cancer in the early months of the COVID-19 pandemic, followed by a return to normal or near-normal levels in the summer of 2020. Objective: To determine the observed vs. expected mammography and low dose computed tomography rates from the beginning of the pandemic through April 2022. Methods: Retrospective cohort study assessing mammography and low dose computed tomography rates from January 2017 through April 2022. Data for January 2016 to February 2020 were used to generate expected rates for the period March 2020 to April 2022.Setting: United States Medicare population. Participants: A 20% national sample of Medicare fee-for-service enrollees among women aged 50-74 for mammography, and men and women aged 55-79 for low dose computerized tomography. Main outcome: Receipt of screening mammography or low dose computed tomography. Results: From January 2017 through February 2020, monthly mammography rates were flat, while there was a monotonic increase in low dose computed tomography rates, from approximately 500 per million per month in early 2017 to 1100 per million per month by January 2020. Over the period from March 2020 to April 2022, there were episodic drops in both mammography and low dose computed tomography rates, coincident with increases in national COVID-19 infection rates. For the periods from March 2020 to February 2020 and March 2021 to February 2022, the observed low dose computed tomography rates were 24% (95% Confidence Interval: 23%, 24%) and 14% (95% Confidence Interval: 13%, 15%) below expected rates, while mammography rates were 17% (95% Confidence Interval: 17%, 18%) and 4% (95% Confidence Interval: 4%, 3%) below expected. Conclusions and Relevance: The negative impact of the COVID-19 pandemic on lung cancer screening and breast cancer screening did not resolve after the initial pandemic surges. Successful interventions to improve screening rates should address pandemic-specific reasons for low screening participation.
Citation Format: Christopher Huy D. Doan, Shuang Li, James Goodwin. Continued depression of breast and lung cancer screening among Medicare enrollees during the COVID-19 pandemic. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr P019.
Metabolomic Signatures Associated With Pulmonary Arterial Hypertension Outcomes
Authors: Pi Hongyang , Xia Lu , Ralph David D. , Rayner Samuel G. , Shojaie Ali , Leary Peter J. , Gharib Sina A. 
Published: January 2023

Background:
Pulmonary arterial hypertension (PAH) is a complex disease characterized by progressive right ventricular (RV) failure leading to significant morbidity and mortality. Investigating metabolic features and pathways associated with RV dilation, mortality, and measures of disease severity can provide insight into molecular mechanisms, identify subphenotypes, and suggest potential therapeutic targets.

Methods:
We collected data from a prospective cohort of PAH participants and performed untargeted metabolomic profiling on 1045 metabolites from circulating blood. Analyses were intended to identify metabolomic differences across a range of common metrics in PAH (eg, dilated versus nondilated RV). Partial least squares discriminant analysis was first applied to assess the distinguishability of relevant outcomes. Significantly altered metabolites were then identified using linear regression, and Cox regression models (as appropriate for the specific outcome) with adjustments for age, sex, body mass index, and PAH cause. Models exploring RV maladaptation were further adjusted for pulmonary vascular resistance. Pathway enrichment analysis was performed to identify significantly dysregulated processes.

Results:
A total of 117 participants with PAH were included. Partial least squares discriminant analysis showed cluster differentiation between participants with dilated versus nondilated RVs, survivors versus nonsurvivors, and across a range of NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels, REVEAL 2.0 composite scores, and 6-minute-walk distances. Polyamine and histidine pathways were associated with differences in RV dilation, mortality, NT-proBNP, REVEAL score, and 6-minute walk distance. Acylcarnitine pathways were associated with NT-proBNP, REVEAL score, and 6-minute walk distance. Sphingomyelin pathways were associated with RV dilation and NT-proBNP after adjustment for pulmonary vascular resistance.

Conclusions:
Distinct plasma metabolomic profiles are associated with RV dilation, mortality, and measures of disease severity in PAH. Polyamine, histidine, and sphingomyelin metabolic pathways represent promising candidates for identifying patients at high risk for poor outcomes and investigation into their roles as markers or mediators of disease progression and RV adaptation.
How Do We Experience Digital Arts? An Exploration through Latour’s Modes of Existence
Authors: Schlienger Dominik 
Published: January 2023

AbstractThis article explores the divergence between the practice and theory of technology as observed through an interdisciplinary free-improvisation workshop that critically engaged with (digital) technology Bruno Latour’s “technical mode of existence” proposes an intriguing interpretation of this differentiation. What is it that we experience when we engage with “digital art”? How does this bear on conceptualizations of technologies? The “fictional” and “reference” modes of existence further aid in understanding the digital as it pervades culture and media. Using examples from music, visual arts, and observations from the workshop, dystopian visions of technology are disentangled and reconfigured. Embodied agency and kinesthesia play a major role in this process.
International Law in Central Asia: Practices and Doctrines
Authors: Sayapin Sergey 
Published: January 2023

Abstract
Since their independence in 1991, the states of Central Asia (Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan) have become increasingly important as regional and international actors. They have joined the United Nations (UN) as well as regional organizations, such as the Commonwealth of Independent States (cis), the Collective Security Treaty Organization (csto), the Shanghai Cooperation Organisation (sco), and the Eurasian Economic Union (eaeu). International law has played an important role in the processes of state-building and integration these countries have undergone, yet it has not always been consistently accepted as a policy tool and academic discipline. In particular, building a stable nexus between the practice of international law and academic research on the subject remains a challenge. This article provides an overview of Central Asian practices and doctrines of international law with a focus on international peace and security, international organizations, international environmental law, human rights, international humanitarian and criminal law, and international investment arbitration. It concludes with recommendations for more successful promotion and implementation of international law in the region.