bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Milky-Way-like galaxies like the Milky Way? A view from SDSS-IV/MaNGA
Authors: Zhou Shuang , Aragón-Salamanca Alfonso , Merrifield Michael , Andrews Brett H , Drory Niv , Lane Richard R 
Published: March 2023

ABSTRACTIn this paper, we place the Milky Way (MW) in the context of similar-looking galaxies in terms of their star-formation and chemical evolution histories. We select a sample of 138 Milky Way analogues (MWAs) from the SDSS-IV/MaNGA survey based on their masses, Hubble types, and bulge-to-total ratios. To compare their chemical properties to the detailed spatially-resolved information available for the MW, we use a semi-analytic spectral fitting approach, which fits a self-consistent chemical-evolution and star-formation model directly to the MaNGA spectra. We model the galaxies’ inner and outer regions assuming that some of the material lost in stellar winds falls inwards. We also incorporate chemical enrichment from type II and Ia supernovae to follow the alpha-element abundance at different metallicities and locations. We find some MWAs where the stellar properties closely reproduce the distribution of age, metallicity, and alpha enhancement at both small and large radii in the MW. In these systems, the match is driven by the longer time-scale for star formation in the outer parts, and the inflow of enriched material to the central parts. However, other MWAs have very different histories. These divide into two categories: self-similar galaxies where the inner and outer parts evolve identically; and centrally-quenched galaxies where there is very little evidence of late-time central star formation driven by material accreted from the outer regions. We find that, although selected to be comparable, there are subtle morphological differences between galaxies in these different classes, and that the centrally-quenched galaxies formed their stars systematically earlier.
HD 42477: coupled r modes, g modes, and a p mode in an A0Vnne star
Authors: Kurtz D W , Jayaraman R , Sowicka P , Handler G , Saio H , Labadie-Bartz J , Lee U 
Published: March 2023

ABSTRACT
Several studies have shown that a number of stars pulsating in p modes lie between the β Cep and δ Sct instability strips in the Hertzsprung–Russell (HR) Diagram. At present, there is no certain understanding of how p modes can be excited in this Teff range. The goal of this work is to disprove the conjecture that all stars pulsating in p modes and lying in this Teff range are the result of incorrect measurements of Teff, contamination, or the presence of unseen cooler companions lying in the δ Sct instability strip (given the high binary fraction of stars in this region of the HR Diagram). Using TESS data, we show that the A0Vnne star HD 42477 has a single p mode coupled to several r modes and/or g modes. We rule out a contaminating background star with a pixel-by-pixel examination, and we essentially rule out the possibility of a companion δ Sct star in a binary. We model the pulsations in HD 42477, and suggest that the g modes are excited by overstable convective core modes. We also conjecture that the single p mode is driven by coupling with the g modes, or that the oblateness of this rapidly-rotating star permits driving by He ii ionization in the equatorial region.
Effects of a high-fat diet on the bone structure of Wistar rats: a systematic review
Authors: Silva Rafael T , Ferreira Luciana J D , Macêdo Ana P A , Santos Lucimeire S , Santo Djane A E , Codeiro Gabriele S , Pereira Marcia U , Medeiros Ingrid O R , da Costa Carlos A S , Medeiros Jairza M Barreto 
Published: March 2023

Abstract

Context
Saturated fats found in diets known as high-fat, cafeteria, or Western diets appear to have a negative effect on bone structure; however, few studies have focused on investigating this association, and the data available in the literature remain controversial.

Objective
The aim of the current review was to investigate the effects of a high-fat dietary intake on the bone structure of Wistar rats.

Data Sources
A search for articles was carried out in the Pubmed/MEDLINE, Web of Science, Embase, and Scopus databases.

Data Extraction
In total, 447 articles were found in the initial search; 5 articles were included in the systematic review, after application of the exclusion criteria.

Data Analysis
The review was guided by the PICOS strategy and based on the PRISMA protocol for animal reviews.

Conclusion
High-fat diets appear to affect bone structure of Wistar rats. Diet composition and exposure time are the factors determining the strength of the effect.
Childhood Cancer Survivors’ Reported Late Effects, Motivations for Seeking Survivorship Care, and Patterns of Attendance
Authors: Signorelli Christina , Wakefield Claire E , McLoone Jordana K , Johnston Karen A , Mertens Ann C , Osborn Michael , Cohn Richard J ,   ANZCHOG Survivorship Study Group, Alvaro Frank , Cohn Richard , Corbett Rob , Downie Peter , Egan Karen , Ellis Sarah , Emery Jon , Fardell Joanna , Foreman Tali , Gabriel Melissa , Girgis Afaf , Graham Kerrie , Johnston Karen , Jones Janelle , Lockwood Liane , Maguire Ann , McCarthy Maria , McLoone Jordana , Mechinaud Francoise , Molloy Sinead , Moore Lyndal , Osborn Michael , Signorelli Christina , Skeen Jane , Tapp Heather , Till Tracy , Truscott Jo , Turpin Kate , Wakefield Claire , Williamson Jane , Walwyn Thomas , Yallop Kathy 
Published: March 2023

Abstract

Background
Childhood cancer survivors are vulnerable to long-term treatment-related health conditions, which can lead to poor quality of life. Little data exist on the overall health of long-term Australian and New Zealand childhood cancer survivors or on survivors’ motivations for attending survivorship clinics.

Methods
This study administers a cross-sectional questionnaire to long-term survivors ≥5 years from their primary diagnosis. We compared participant-reported number of late effects by a cancer diagnosis, and identified clinical (eg, treatment) and demographic (eg, age) factors that were associated with late effects burden and engagement in cancer survivorship care.

Results
A total of 634 participants completed questionnaires (48% male, mean age = 21.7 years). Most participants (79%) reported at least one cancer-related late effect, most commonly fatigue (40%) and memory/learning difficulties (34%). Brain tumor survivors reported a higher total number of late effects than survivors with other diagnoses (mean = 5.7 vs. 3.2, P &lt; .001). Participants’ most commonly reported motivators for engaging in care were to understand problems that may occur later in life because of their cancer and/or treatment (98.5%) and to get reassurance about one’s health (97.4%). The proportion of survivors endorsing each motivating factor was similar across cancer diagnoses, with the exception of learning more about insurance and pensions (highest in brain tumor survivors = 80%). In multivariable analyses, survivors were more likely to report being engaged in survivorship care if they were younger (P &lt; .001), less time had elapsed since their diagnosis (P &lt; .001), or they reported a higher number of motivating factors (P = .016).

Conclusion
Survivors report a range of health problems decades after treatment completion. Understanding the burden of late effects, and motivators for seeking survivorship care to manage these health problems, is important for ensuring that tailored interventions or services are available to meet the needs of this growing population and to design effective models of survivorship care.
Coordinate Normalization of Live-Cell Imaging Data Reveals Growth Dynamics of the Arabidopsis Zygote
Authors: Kang Zichen , Matsumoto Hikari , Nonoyama Tomonobu , Nakagawa Sakumi , Ishimoto Yukitaka , Tsugawa Satoru , Ueda Minako 
Published: March 2023

Abstract
Polarization of the zygote defines the body axis during plant development. In Arabidopsis (Arabidopsis thaliana), the zygote becomes polarized and elongates in the longitudinal direction, ultimately forming the apical–basal axis of the mature plant. Despite its importance, the mechanism for this elongation remains poorly understood. Based on live-cell imaging of the zygote, we developed new image analysis methods, referred to as coordinate normalization, that appropriately fix and align positions in an image, preventing fluctuation across a temporal sequence of images. Using these methods, we discovered that the zygote elongates only at its apical tip region, similar to tip-growing cells such as pollen tubes and root hairs. We also investigated the spatiotemporal dynamics of the apical tip contour of the zygote and observed that the zygote tip retains its isotropic, hemispherical apical shape during cell elongation. By looking at the elliptical fitting of the contour over time, we further discovered that the apical cell tip becomes thinner at first and then thickens, with a transient increase in growth speed that is followed by the first cell division. We performed the same series of analyses using root hairs and established that both the hemispherical tip shape and the changes in growth rate associated with changes in tip size are specific to the zygote. In summary, the Arabidopsis zygote undergoes directional elongation as a tip-growing cell, but its tip retains an unusual isotropic shape, and the manner of growth changes with the developmental stage.
FLOWERING LOCUS T mediates photo-thermal timing of inflorescence meristem arrest in Arabidopsis thaliana
Authors: González-Suárez Pablo , Walker Catriona H , Bennett Tom 
Published: March 2023

Abstract
Plants integrate environmental information into their developmental program throughout their lifetime. Light and temperature are particularly critical cues for plants to correctly time developmental transitions. Here, we investigated the role of photo-thermal cues in the regulation of the end-of-flowering developmental transition in the model plant Arabidopsis (Arabidopsis thaliana). We found that increased day length and higher temperature during flowering promote earlier inflorescence arrest by accelerating the rate at which the inflorescence meristem (IM) initiates floral primordia. Specifically, we show that plants arrest at a photo-thermal threshold and demonstrate that this photo-thermally mediated arrest is mediated by the floral integrator FLOWERING LOCUS T (FT), a known activator of flowering. FT expression increased over the duration of flowering, peaking during IM arrest, and we show that this is necessary and sufficient for photo-thermally induced arrest. Our data demonstrate the role of light and temperature, through FT, as key regulators of end-of-flowering. Overall, our results have important implications for understanding and modulating the flowering duration of crop species in changing light and temperature conditions in a warming global climate.
Evaluation of the effectiveness of alginate-based hydrogels in preventing peritoneal adhesions
Authors: Meng Zhu , Wang Han , Liu Yu , Yang Minyi , Zeng Hang , Han Qianqian 
Published: March 2023

AbstractInfertility and intestinal blockage are just two examples of the postoperative consequences that can arise from peritoneal damage, which can also result in severe peritoneal fibrosis and peritoneal adhesions. Peritoneal adhesions are still not effectively treated, and both pharmaceutical therapy and biomaterial barriers have only had modest preventative effects. In this work, we looked into the effectiveness of in-place injectable sodium alginate hydrogel for peritoneal adhesion prevention. The findings demonstrated that sodium alginate hydrogel promoted human peritoneal mesothelial cell proliferation and migration, prevented peritoneal fibrosis by suppressing the production of transforming growth factor-β1, and, most importantly, promoted mesothelium self-repair. These findings imply that this brand-new sodium alginate hydrogel is a good candidate material for peritoneal adhesion prevention.
Metabolic and inflammatory profiles define phenotypes with clinical relevance in female knee osteoarthritis patients with joint effusion
Authors: Calvet Joan , García-Manrique María , Berenguer-Llergo Antoni , Orellana Cristóbal , Cirera Silvia Garcia , Llop Maria , Galisteo Lencastre Carlos , Arévalo Marta , Aymerich Cristina , Gómez Rafael , Giménez Néstor Albiñana , Gratacós Jordi 
Published: March 2023

Abstract

Objectives
Osteoarthritis has been the subject of abundant research in the last years with limited translation to the clinical practice, probably due to the disease’s high heterogeneity. In this study, we aimed to identify different phenotypes in knee osteoarthritis (KOA) patients with joint effusion based on their metabolic and inflammatory profiles.

Methods
A non-supervised strategy based on statistical and machine learning methods was applied to 45 parameters measured on 168 female KOA patients with persistent joint effusion, consecutively recruited at our hospital after a monographic OA outpatient visit. Data comprised anthropometric and metabolic factors and a panel of systemic and local inflammatory markers. The resulting clusters were compared regarding their clinical, radiographic and ultrasound severity at baseline and their radiographic progression at two years.

Results
Our analyses identified four KOA inflammatory phenotypes (KOIP): a group characterized by metabolic syndrome, probably driven by body fat and obesity, and by high local and systemic inflammation (KOIP-1); a metabolically healthy phenotype with mild overall inflammation (KOIP-2); a non-metabolic phenotype with high inflammation levels (KOIP-3); and a metabolic phenotype with low inflammation and cardiovascular risk factors not associated with obesity (KOIP-4). Of interest, these groups exhibited differences regarding pain, functional disability and radiographic progression, pointing to a clinical relevance of the uncovered phenotypes.

Conclusion
Our results support the existence of different KOA phenotypes with clinical relevance and differing pathways regarding their pathophysiology and disease evolution, which entails implications in patients’ stratification, treatment tailoring and the search of novel and personalized therapies.
Premenstrual dysphoric disorder and sexual function: a narrative review
Authors: Susser Leah C , Parish Sharon , Dumas Emily , Nappi Rossella E 
Published: March 2023

Abstract

Introduction
Premenstrual dysphoric disorder (PMDD) and female sexual dysfunction (FSD) are 2 prevalent illnesses in women that cause distress and affect quality of life. There are plausible biological, social, and psychological links between these 2 conditions. Nevertheless, few studies have examined sexual function in women with PMDD.

Objectives
In this narrative review we summarize the existing literature on sexual function in women with PMDD and with the broader diagnostic classification of premenstrual syndrome and discus the differences between PMDD and more general premenstrual symptomatology, as well as why studying sexual function specifically in PMDD is necessary. We explored reasons why these 2 illnesses may be comorbid and the importance of studying sexual function in this population of women.

Methods
PubMed literature searches were conducted using relevant keywords.

Results
Currently, there are few studies examining PMDD and FSD, and the studies available have significant methodologic limitations.

Conclusions
Investigation of sexual function in women with PMDD is needed. Awareness of the comorbidities for PMDD and FSD can allow implementation of targeted interventions for women suffering from these disorders.
Goodbye and good riddance to the doctrines of “fraud on a power” and “the entire substratum”—now if only we could figure out the “proper purpose” rule
Authors: Nitikman Joel 
Published: March 2023

Abstract
The equitable doctrine of “fraud on a power” (now sometimes called either the “improper purpose” or the “proper purpose” rule) was created almost 300 years ago with one judge’s off-the-cuff remark. Since then the doctrine has grown by leaps and bounds, to the point where entire books are written about it. Yet it is questionable whether the doctrine has any real meaning or jurisprudential basis. The same is true of the so-called substratum rule. Joel Nitikman, K.C., discusses both doctrines in the context of the Privy Council’s recent decision in Grand View Private Trust v. Wang, on appeal from the Bermuda Court of Appeal. He concludes that both concepts should be discarded, with the focus being instead on a simple question: what is the scope of the power as written?
Older Adults’ and Family Caregivers’ Technological Arrangements on Risk of Institutionalization
Authors: Kim Yijung K , Ang Shannon , Fingerman Karen L 
Published: March 2023

Abstract
Internet-enabled resources could facilitate older adults’ ability to live in the community longer, but studies have often overlooked how family caregivers utilize the internet to assist older care recipients. We examined whether different family-level arrangements of internet use may affect the risk of institutionalization among older adults. Using the National Health and Aging Trends Study (2015–2020) and National Study on Caregiving (2015), we estimated multinominal logistic regression and inverse-probability weighted Cox proportional hazard models to investigate the determinants of technological arrangements in 2015 (i.e., no internet use, only caregiver use, only care recipient use, both caregiver and care recipient internet use) and how they may affect the risk of moving to an assisted living or nursing facility between 2015 and 2020. The most prevalent technological arrangement in 2015 was the one where neither the care recipient nor their caregiver reported using the internet. Relatively disadvantaged older care recipients (e.g., people of color, fewer years of education, less income, worse cognitive functioning) and caregivers (e.g., older, fewer years of education) were more likely to be in a non-internet use arrangement. Compared to older adults in other categories, older adults who were internet users and had a family caregiver who also used the internet in their caregiving tasks had a much lower risk of relocation during the study period. Findings suggest that digital interventions aimed at serving the older adult population should assess the gap in access and utilization at a family level and consider the role of older adults’ social partners.
First phylogeny ofTrichomyia(Diptera: Psychodidae: Trichomyiinae) based on morphological data of adults
Authors: Araújo Maíra Xavier , Bravo Freddy , de Carvalho Claudio José Barros 
Published: March 2023

AbstractTrichomyia is a cosmopolitan genus, and it is the only genus of Trichomyiinae to include extant species. In recent years, an increasing number of species belonging to the genus have been described, particularly from the Neotropics. However, phylogenetic studies of these species are lacking. In addition, few studies have focused on this group, and none has focused on it exclusively, making it difficult to classify objectively the high diversity known today. Herein, we present the first phylogenetic analysis of Trichomyia. We studied specimens from all continents to propose a phylogeny and used it as the basis of a new classification. Two clades proposed as genera were recovered. The canonical informal classification of Trichomyia into Groups A and B is discussed, and Gondwanotrichomyia is assigned a new status. Although we do not propose a subgeneric classification for Trichomyiinae, we provide some comments on the previously proposed subgenera based on our phylogeny. In addition, we report on the expanded distribution of Trichomyia festiva, Trichomyia gabia and Trichomyia imarui.
Congenital Pseudarthrosis of the Tibia: Long-term Outcome of Treatment With Intramedullary Vascularized Fibular Graft Combined With Ilizarov Distraction
Authors: El-Gammal Tarek Abdalla , Ali Amr El-Sayed , Kotb Mohamed Mostafa , Saleh Waleed Riad , Ragheb Yasser Farouk , Refai Omar Ahmed , Morsy Mohamed Mohamed , El-Gammal Yousif Tarek 
Published: March 2023

Background:
Late presenting cases of congenital pseudarthrosis of the tibia, are further complicated with severe shortening. Limb length discrepancy (LLD) cannot be corrected by vascularized fibular grafting and the use of Ilizarov distraction is associated with a high rate of complications. The aim of this study was to report the long-term follow-up of a combined technique previously published under the name “telescoping vascularized fibular graft”.

Materials and methods:
Eleven patients operated at an average age of 10.2±3.2 years were reviewed. All cases were Crawford type IV affected by neurofibromatosis 1. Nine patients had an average of 4.3 previous operations. Preoperative LLD averaged 7.9±2.5 cm.

Results:
Follow-up averaged 10±5.4 years. Seven cases (63.6%) reached skeletal maturity before final follow-up. Primary union was achieved in all cases after an average of 7.2±1.3 months. Full weightbearing was possible after an average of 10.6±2.2 months. Recurrent stress fractures occurred in 9 cases (81.8%) and healed with casting in 6 cases and required internal fixation in 3 cases. Eight cases (72.8%) developed tibial shaft deformities, mainly procurvatum that required corrective osteotomy in 2 cases. Final LLD averaged 2.7±1.3 cm. Complete tibialization of the graft was achieved after an average of 17.0 ± 3.6 months. Valgus deformity of the ipsilateral ankle averaged 12.4 degrees±7.5.

Conclusion:
The presented technique avoids osteotomy of the diseased bone and allows simultaneous treatment of the pseudarthrosis and correction of shortening. Compared with conventional bone transport, it requires shorter time of frame application and therefore better patient tolerability because there is no waiting for consolidation of the regenerate. The dis-impaction of the doweled fibula occurs proximally, allowing the less active site located at the distal aspect of the pseudarthrosis to heal without displacement. A shortcoming of the presented technique is the more propensity for axial deviation and refractures that seldom require surgery.

Level of Evidence:
Level—IV
Behind the Curtain: Therapeutic Drug Monitoring of Psychotropic Drugs from a Laboratory Analytical Perspective
Authors: Scherf-Clavel Maike , Baumann Pierre , Hart Xenia M. , Schneider Heike , Schoretsanitis Georgios , Steimer Werner , Zernig Gerald , Zurek Gabriela 
Published: March 2023

Purpose:
Therapeutic drug monitoring (TDM) is a well-established tool for guiding psychopharmacotherapy and improving patient care. Despite their established roles in the prescription of psychotropic drugs, the “behind the curtain” processes of TDM requests are invariably obscure to clinicians, and literature addressing this topic is scarce.

Methods:
In the present narrative review, we provide a comprehensive overview of the various steps, starting from requesting TDM to interpreting TDM findings, in routine clinical practice. Our goal was to improve clinicians' insights into the numerous factors that may explain the variations in TDM findings due to methodological issues.

Results:
We discussed challenges throughout the TDM process, starting from the analyte and its major variation forms, through sampling procedures and pre-analytical conditions, time of blood sampling, sample matrices, and collection tubes, to analytical methods, their advantages and shortcomings, and the applied quality procedures. Additionally, we critically reviewed the current and future advances in the TDM of psychotropic drugs.

Conclusions:
The “behind the curtain” processes enabling TDM involve a multidisciplinary team, which faces numerous challenges in clinical routine. A better understanding of these processes will allow clinicians to join the efforts for achieving higher-quality TDM findings, which will in turn improve treatment effectiveness and safety outcomes of psychotropic agents.