bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contratos, curva de Phillips y política monetaria
Authors: Jiménez Félix 
Published: March 2023

Este trabajo muestra que la existencia de contratos implícitos o explícitos, da lugar a desvíos de la producción respecto de su nivel de pleno empleo y, por lo tanto, a la configuración de una curva de oferta agregada de corto plazo con pendiente positiva. Estos desvíos pueden asimismo expresarse con una curva de Phillips. Definida la curva de Phillips, se integra una regla de política monetaria que permite modelar los efectos de la reacción del Banco Central ante los desvíos de la inflación respecto de la inflación meta. Se desarrolla un modelo con una función de pérdida del Banco Central para luego obtener una regla monetaria óptima que modifica la versión sintética de la Regla de Taylor. Este modelo permite realizar análisis de estática comparativa a corto plazo.
Trust and Accountability: Legal Implications of Train Delays
Authors: Churniawan Erifendi 
Published: March 2023

This normative legal research with statutory and conceptual approaches aims to analyze the implications of train delays according to schedule in a progressive legal perspective and to construct ethical and legal responsibility for such delays. The results reveal that train delays not only harm passengers but also decrease public trust in rail services. In a progressive legal perspective, trust is the fundamental element for law to serve human interests. To address this issue, a minister of transportation regulation should be established to hold train service managers accountable for delays and provide ethical and legal obligations to passengers. By learning from the accountability of aircraft delays, such regulations can be adapted to rail transportation.

Highlights:

Train delays have negative consequences for passengers and public trust in rail services.
Trust is a fundamental element for law to serve human interests.
A minister of transportation regulation should be established to hold train service managers accountable for delays and provide ethical and legal obligations to passengers.
Human Bone Marrow Mesenchymal Stem Cell-derived Extracellular Vesicles Restore Th17/Treg Homeostasis in Periodontitis via miR-1246
Authors: Xia Yuxing , Cheng Tianfan , Zhang Chengfei , Zhou Min , Hu Zhekai , Kang Feiwu , Liao Chongshan 
Published: March 2023

Abstract
T-cell-mediated immunity is crucial in the immunopathology of periodontitis. The restoration of the equilibrium between the T helper cell 17 (Th17) and regulatory T cell (Treg) subsetsby extrcellular vesicles (EVs) obtained from human bone marrow stem cells (hBMSCs) promotes new bone formation and suppresses inflammation. Uncovering the functions of hBMSC-derived EVs in the immune microenvironment of periodontal tissue and their underlying regulatory mechanisms may shed new light on the development of a potential cell-free immunotherapy for periodontal regeneration. Here we report that The Th17/Treg ratio was elevated in peripheral blood from periodontitis patients. Furthermore,we found that hBMSC-derived EVs could reduce the Th17/Treg ratio in CD4+ T cells from periodontitis patients in vitro and ameliorated experimental periodontitis in mice. Additionally, miRNA sequencing was used to investigate the differentially expressed miRNAs and target genes in EVs from hBMSCs stimulated with P. gingivalis LPS. Our findings indicate that EV-miR-1246 is highly effective at down-regulating the ratio of Th17/Treg in vitro. Mechanistically, EV-miR-1246 suppressed angiotensin-converting enzyme 2 (ACE2) expression and increased the p-Yes-associated protein (YAP)1/YAP1 ratio in CD4+ T cells. Our results indicate that hBMSC-derived EVs improve periodontitis by miR-1246, consequently downregulating Th17/Treg ratio, and represent a promising therapeutic target for precision treatment in periodontitis.
Adult Patient Satisfaction With Nursing Care Services and Associated Factors Among Admitted Patients at Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia, 2022
Authors: Bogale Bantalem Amanu , Ahmed Sindew Mahmud , Gebrekidan Aynie Birhane , Bogale Getachew Amanu 
Published: March 2023

Abstract
Background: Around the world, providing holistic nursing care and ensuring patient satisfaction have become crucial health-care performance indicators. Despite a lot of efforts to improve patient satisfaction with nursing care, the approach in the developing world, including Ethiopia, is still insufficient.
Objective: The aim of this study was to assess adult patients’ satisfaction with nursing care services and identify the factors affecting satisfaction at Saint Paul’s hospital millennium medical college, 2022.
Methods: Cross-sectional study was conducted at Saint Paul’s hospital millennium medical college. A simple random sampling technique was used to select 422 study participants. The actual sample was distributed using proportional allocation for each selected adult inpatient departments. Participants were interviewed using a modified structured Amharic version of ‘Newcastle Satisfaction with Nursing Scale’ tool from June 20/2022 to July 30/2022. Data analysis was made by SPSS version 26. Bivariate and multivariable logistic regression analysis was used to identify factors associated with adult patient satisfaction. Statistical association was declared using 95% CI and a p-value of < 0.05.
Results: The overall level of patient satisfaction with nursing care was 54.3%. Respondents who had no formal education (AOR=8.482; 95% CI=1.678-42.87), being male (AOR=2.487; 95% CI=1.038-5.959) (P-value=0.041), free service consumers (AOR=6.650; 95% CI: 2.677-16.517), health insurance user (AOR=7.309; 95% CI=3.122-17.110) (P-value=0.000), was significantly associated with satisfaction with nursing care. In addition patients’ who had admission history (AOR=0.261; 95% CI=0.122-0.560), governmental workers (AOR=0.090; 95% CI=0.026-0.310) (P-value=0.000) and patients admitted in medical ward (AOR=0.160; 95% CI=0.039-0.649) (P-value=0.010) were associated with patient dissatisfaction with the nursing care services.
Conclusion and recommendations: The finding showed that patient satisfaction with nursing care was rated low. Admission history, higher education level, paid cash for service, private and governmental workers were significant predisposing factors to dissatisfaction with nursing care. On the other hand, patients who had no formal education, free service consumers, and being male were significant predictors of satisfaction with the nursing care services. Therefore, it is recommended to include all communities with health insurance schemes and the hospital administration to better give emphasis to patient needs and expectations.
Long-term Energy System Modelling for a Clean Energy Transition in Egypt's Energy Sector
Authors: Gibson Anna 
Published: March 2023

Abstract
Egypt has the potential to generate significant amounts of renewable energy, in particular solar PV, concentrated solar power (CSP), and onshore and offshore wind. The energy sector is reliant on fossil fuels, particularly natural gas, for electricity production and is at risk of locking itself into a high carbon pathway. Globally, reducing greenhouse gas (GHG) emissions associated with national energy sectors is a target outlined in the UN’s Paris Agreement. To reduce carbon dioxide (CO2) emissions associated with a higher dependence on fossil fuels, Egypt must consider upscaling renewable energy technologies (RET) to achieve a clean energy transition (CET).

This research modelled six scenarios using OSeMOSYS to identify the technologies and policy target improvements that are needed to upscale RETs within Egypt’s energy sector. The results showed that solar PV and onshore wind are key technologies to be upscaled to contribute towards Egypt’s CET. The optimal renewable target is the International Renewable Energy Agency’s (IRENA) 53% of electricity to be sourced from RETs by 2030, which will cost $16.4 billion more up to 2035 than Egypt’s current Integrated Sustainable Energy Strategy (ISES) target of 42% by 2035; it also saves 732.0 Mt of CO2 over the entire modelling period to 2070.

Socio-economic barriers to this transition are considered, such as recent discoveries of natural gas reserves combined with a history of energy insecurity, political instability impacting investor confidence, and a lack of international climate funding. The paper concludes with policy recommendations that would enable Egypt to progress towards achieving a CET.
Mechanically Controlled High-Performance Molecular Photoswitch
Authors: Li Yuan , Yang Zhenyu , Cazade Pierre-André , Lin Jin-Liang , Cao Zhou , Chen Ningyue , Zhang Dongdong , Duan Lian , Nijhuis Christian , Thompson Damien 
Published: March 2023

AbstractSimplified and energy-efficient electronic devices that respond to multiple external stimuli (e.g., voltage, light, and mechanical stress) are needed for nascent technologies ranging from soft robotics and neuromorphic computing to Internet-of-Things1-3. Yet most research to-date focused on one switching modality with one stimulus4-6. Here we align materials design with device technology by introducing mechanical control over photoswitching leading to a new type of dual-gated molecular switch. While molecular switches are inherently energy-efficient7, theoretically ultrafast molecular photoswitches showed disappointing performance to-date, with small on/off ratio of electric current, poor reproducibility, and slow or stochastic switching8,9. It has been particularly challenging to develop efficient photoswitches in molecular tunnel junctions due to quenching and spontaneous back-switching10. On the other hand, molecular mechanical switches have been seldom reported11, despite wide implementation of mechanically-controlled switches12-14. Here, we use mechanical bending of the supporting electrode to direct molecular self-assembly of aggregation-induced emission (AIE) active molecules15,16, which allows us modulate the current under both light and mechanical force. This results in rapid, strong, reliable and sustained molecular switching. The high-performance photoswitch is 10-100 times faster than other approaches with on/off ratio of (3.8±0.1)×103during 1600 bright/dark cycles under mechanical force, providing an alternative design route for flexible electronics and optomechatronics.
Impact of administered amount of peptide on tumor dosimetry at the first cycle of peptide receptor radionuclide therapy (PRRT) in relation to total tumor somatostatin receptor expression
Authors: Jahn Ulrika , Garske-Román Ulrike , Sandström Mattias , Lubberink Mark , Sundin Anders 
Published: March 2023

Abstract
Background: The accumulation of 177 Lu-DOTATATE might be influenced by the amount of administered peptide in relation to the tumor somatostatin receptor expression. The effect of the administered peptide mass on the resulting absorbed dose in tumors and normal organs has not previously been assessed in relation to the patients’ tumor load.
Method: Patients with small intestinal (n=141) and pancreatic (n=62) neuroendocrine tumors (NETs) who underwent PRRT, were selected for retrospective evaluation. All patients had received 7.4 GBq 177Lu-DOTATATE, and the amount of administered peptide in the preparation varied from 78 µg to 456 µg. The absorbed dose in tumors and normal tissue at the first PRRT cycle was calculated, based on SPECT-measurements at day 1, 4, and 7 post infusion. The total tumor somatostatin receptor expression (tTSSTRE) was calculated on SPECT after 24 hours by multiplying the functional tumor volume, delineated by 42% cut-off VOIs of the highest activity, with the SUVmean for the respective tumor VOIs. Spearman’s rank correlation analyzed any relationship between the administered amount of peptide and the absorbed dose in tumors and normal organs, in relation to the patients’ tTSSTRE.
Results: There was no correlation between the amount of peptide and any of the tested parameters in relation to tTSSTRE.
Conclusion: In this retrospective analysis, no correlation between the amount of administered peptide in the 177Lu-DOTATATE preparation and the absorbed radiation doses in tumors and normal tissues was demonstrated in relation to the total tumor SSTR expression.
When roots are overexposed to ZnO nanoparticles, the absorbed zinc accumulates in the root cell wall, inhibiting root elongation and chlorophyll production
Authors: Tokumoto Hayato , Yoshihara Shizue , Yamamoto Kasumi , Nakajima Yoshino , Ibuchi Kana , Nomura Toshiyuki , Kurahashi Kensuke 
Published: March 2023

Abstract
Engineered ZnO nanoparticles exist in particle and ion states in aqueous solutions. This study was compared the exposure of different state Zn for lettuce seedlings as in vitro organ culture of root using lettuce seedlings for short time in petri dish. 0.74 mg L− 1 of Zn2+ ions dissociated from ZnCl2 promoted root elongation in lettuce seedlings. However, at the same Zn2+ ion concentration, ZnO nanoparticle dispersions had an inhibitory effect on root elongation. Additionally, 2.40 mg L− 1 of Zn2+ ions in a ZnCl2 solution inhibited lettuce root elongation. Water-insoluble SiO2 and TiO2 nanoparticles dispersions had no effect on root elongation, suggesting that the negative impact of metal oxide nanoparticles on root elongation may be specific to ionizable nanoparticles like ZnO. The Zn content in lettuce roots incubated with ZnO nanoparticle dispersions was 8-fold higher than that in ZnCl2 solution-incubated roots. 20 mg L− 1 ZnO nanoparticle dispersion reduced chlorophyll contents in the lettuce seedlings, and all plants died after transplanting into a medium without ZnO nanoparticles. Inhibition of root elongation by ZnO nanoparticle dispersions and ZnCl2 solutions was accompanied by changes in the polysaccharide content of roots, especially the water-soluble components of cell walls increased. Excess intracellular zinc increases the water-soluble fraction of the cell wall, leading to accumulation of zinc ions and stagnation of root elongation due to abnormal cell wall metabolism. In plants exposed to ZnO nanoparticles, a specific mechanism was clearly identified in which accumulation of zinc to roots results in inhibition of chlorophyll synthesis.
Effects of different starch structures on energy metabolism in pigs
Authors: Gao Xiaoqian , Yu Bing , Yu Jie , Mao Xiangbing , Huang Zhiqing , Luo Yuheng , Luo Junqiu , Zheng Ping , Yan Hui , He Jun , Chen Daiwen 
Published: March 2023

Abstract
Background
Starch is a major component of carbohydrates and a major source of energy for monogastric animals. Starch is composed of amylose and amylopectin and has different physiological functions due to its different configuration and structure. It has been shown that the energy supply efficiency of amylose is lower than that of amylopectin. However, there are few studies on the effect of starch structure on the available energy of pigs. The purpose of this study was to measure the effect of different structures of starch in the diet on the net energy (NE) of pigs using a comparative slaughter method and to establish a prediction equation to estimate the NE of starch with different structures. A total of fifty-six barrows (initial body weight 10.18 ± 0.11kg) were used, and they were housed and fed individually. Pigs were divided into 7 treatments according to their weight, with 8 replicates for each treatment and 1 pig for each replicate. One of the treatments was randomly selected as the initial slaughter group (ISG). Pigs in the remaining groups were assigned to 6 dietary treatment and slaughtered at the conclusion of the experiment. The basic diet contains corn, soybean meal, without additional starch. The other five starch experimental groups were fed semi-pure diets with amylose/amylopectin ratios (AR) of 3.09, 1.47, 0.25, 0.15 and 0.12, respectively. The diets and water were provided ad libitum for 28 d.
Results
Results showed that compared with the high amylose (AM) groups (AR 3.09 and 1.47), the high amylopectin (AP) group (AR 0.15) significantly increased the final BW, average daily weight gain and average daily feed intake of pigs (quadratic, P < 0.01), but the F: G of the high amylose group was lower (quadratic, P < 0.05). In addition, the high amylopectin groups (AR 0.15 and 0.12) has higher (quadratic, P < 0.001) nutrient digestibility of dry matter, crude protein, gross energy and crude ash. Meanwhile, compared with other groups AR 0.15 group has a higher NE intake and energy retention (RE), while AR 3.09 group has the lowest NE intake and RE (linear, P < 0.05). The regressive equation for predicting with starch structures was established as RE = 1235.243-48.298AM/AP (r2=0.657, P = 0.05).
Conclusions
In conclusion, with the increase of dietary amylopectin content, NE intake and RE of pigs were increased, indicating that diets high in amylopectin were more conducive to promoting the growth of pigs in the late conservation period.
Cross-reactive MHC Class I T Cell Epitopes May Dictate Heterologous Immune Responses Between Respiratory Viruses and Food Allergens
Authors: Balz Kathrin , Kaushik Abhinav , Cemic Franz , Sampath Vanitha , Heger Vanessa , Renz Harald , Nadeau Kari , Skevaki Chrysanthi 
Published: March 2023

Abstract
Respiratory virus infections play a major role in asthma inception, persistence, and exacerbations. There is also a close correlation between asthma and food allergy, and we hypothesize that food-allergen-induced T cell-mediated heterologous immunity likely plays a role in inducing asthma symptoms in sensitized individuals. In this study, we used two independent in silico pipelines for the identification of cross-reactive virus- and food allergen- derived T cell epitopes, considering individual peptide sequence similarity, MHC binding affinity and immunogenicity. We assessed the proteomes of human rhinovirus (RV1b), respiratory syncytial virus (RSVA2) and influenza-strains contained in the seasonal quadrivalent influenza vaccine 2019/2020 (QIV 2019/2020), as well as SARS-CoV-2 for the most frequent human HLA alleles, in addition to more than 200 most common food allergen protein sequences. All resulting allergen-derived peptide candidates were subjected to an elaborate scoring system considering multiple criteria, including clinical relevance. In both bioinformatics approaches, we found that shortlisted peptide pairs that are potentially binding to MHC class II molecules scored up to 10x lower compared to MHC class I candidate epitopes. For MHC class I food allergen epitopes, several candidate peptides from shrimp, kiwi, apple, soy bean and chicken were identified. Such allergen sources contained potentially cross-reactive epitopes to the aforementioned viruses. The shortlisted set of peptide pairs may be implicated as heterologous virus-mediated immune response to food allergens. Our findings may be translated to peptide immunization strategies with immunomodulatory properties.
Quantitative variation of usnic acid in response to elevation and microsite conditions in Usnea amblyoclada: chemometric modeling for predicting the effects of climate change
Authors: Díaz Raúl , Peralta Mariana , Rodriguez Juan Manuel 
Published: March 2023

Abstract
Mountain ecosystems provide an opportunity to investigate how organisms respond to different climatic patterns. In this study, we tested the hypothesis that the content of usnic acid (UA) per mass unit and the total extract yield of Usnea amblyoclada (Müll. Arg.) Zahlbr. would increase in exposed microsites (i.e., northern and flat microsites) and at higher elevations (i.e., 1800 m.a.s.l. and 2100 m.a.s.l.). A total of 27 U. amblyoclada extract samples were analyzed. Generalized linear models revealed a significant difference in UA concentration among elevations (p > 0.01). Tukey's post-hoc test indicated that UA concentration was significantly lower at higher elevations (i.e., between 900 and 2100 m.a.s.l.), with no significant differences observed between the 1800 m.a.s.l. and 900 m.a.s.l. elevations, nor between the 1800 and 2100 m.a.s.l. elevations. Our results suggest that temperature is the primary driver of UA content in U. amblyoclada, as UA concentration was lower in samples from higher elevations compared to those from lower elevations.
Feasibility of implementing and integrating cervical cancer screening and treatment of precancerous lesions into the public health system in three states in Nigeria
Authors: Lawson Olufunmilayo , Ameyan Lola , Tukur Zainab , Dunu Sophia , Kerry Matilda , Okuyemi Oluwapelumi Ololade , Yusuf Zainab , Fasawe Olufunke , Wiwa Owens , Hebert Katharine Schilling , Joseph Jessica , Nwokwu Uchechukwu Emmanuel , Okpako Okpikpi , Chime Christopher Ifeanyi 
Published: March 2023

Abstract
Background

Cervical cancer continues to generate a significant burden of disease and death in low- and middle-income countries (LMICs). Lack of awareness and poor access to early screening and pre-cancer treatment contribute to the high mortality. We describe here the implementation and integration of practical routine cervical cancer screen and treat services into the public health system in Nigeria.

Methods

We conducted an observational study in 177 government health facilities in Lagos, Kaduna, and Rivers State, Nigeria from January to December 2021, in which we reviewed programmatic data collected through the newly introduced Cervical Cancer Prevention Program. Women who received screening and provided consent were enrolled into the study. Data were extracted from registers in the health facilities using SurveyCTO and descriptive statistical analysis was conducted using StataSE 15 (StataCorp, College Station, TX, USA).

Results

83,593 women were included in the analysis including 6,043 (7%) WLHIV. 67,371 (81%) received VIA as their primary screening while 16,173 (19%) received HPV DNA testing, with 49 (<1%) receiving both at the same time. VIA positivity was 7% for WLHIV and 3% for general population, while HPV prevalence was 16% for WLHIV and 8% for general population. Following a positive HPV result, 21% of women referred, completed triage examination. 1,956 women were identified with precancerous lesions, and 1,874 (96%) received treatment. Of the 194 suspected cancer cases identified, 85 (44%) were successfully referred to an oncology center for advanced treatment. Following treatment with thermal ablation, seven adverse events were reported.

Conclusions

Routine cervical cancer screening and treatment was found to be feasible in a public-health setting. Almost all women who were eligible for pre-cancerous lesion treatment received it, often on the same day when screened using VIA. However, for women referred for a triage exam or due to suspected cancer, many did not complete their referral visits. More effort is required to ensure HPV positive women and women with suspected cancer are adequately linked to care to further reduce morbidity and mortality associated with cervical cancer in Nigeria. Furthermore, additional investments into strengthening laboratories across the country are necessary for seamless HPV testing.