bluuebunny/crossref_metadata_2025_split huggingface dataset:
Text Messages Exchanged Between Individuals With Opioid Use Disorder and Their mHealth e-Coaches: Content Analysis Study
Authors: Ranjit Yerina S , Davis Warren M , Fentem Andrea , Riordan Raven , Roscoe Rikki , Cavazos-Rehg Patricia 
Published: January 2023

Background
Opioid use disorder (OUD) has affected 2.2 million people in the United States. About 7.2 million people reported using illicit drugs in 2019, which contributed to over 70,000 overdose deaths. SMS text messaging interventions have been shown to be effective in OUD recovery. However, the interpersonal communication between individuals in OUD treatment and a support team on digital platforms has not been well examined.

Objective
This study aims to understand the communication between participants undergoing OUD recovery and their e-coaches by examining the SMS text messages exchanged from the lens of social support and the issues related to OUD treatment.

Methods
A content analysis of messages exchanged between individuals recovering from OUD and members of a support team was conducted. Participants were enrolled in a mobile health intervention titled “uMAT-R,” a primary feature of which is the ability for patients to instantly connect with a recovery support staff or an “e-coach” via in-app messaging. Our team analyzed dyadic text-based messages of over 12 months. In total, 70 participants’ messages and 1196 unique messages were analyzed using a social support framework and OUD recovery topics.

Results
Out of 70 participants, 44 (63%) were between the ages of 31 and 50 years, 47 (67%) were female, 41 (59%) were Caucasian, and 42 (60%) reported living in unstable housing conditions. An average of 17 (SD 16.05) messages were exchanged between each participant and their e-coach. Out of 1196 messages, 64% (n=766) messages were sent by e-coaches and 36% (n=430) by participants. Messages of emotional support occurred the most, with 196 occurrences (n=9, 0.8%) and e-coaches (n=187, 15.6%). Messages of material support had 110 occurrences (participants: n=8, 0.7%; e-coaches: n=102, 8.5%). With OUD recovery topics, opioid use risk factors appeared in most (n=72) occurrences (patient: n=66, 5.5%; e-coach: n=6, 0.5%), followed by a message of avoidance of drug use 3.9% (n=47), which occurred mainly from participants. Depression was correlated with messages of social support (r=0.27; P=.02).

Conclusions
Individuals with OUD who had mobile health needs tended to engage in instant messaging with the recovery support staff. Participants who are engaged in messaging often engage in conversations around risk factors and avoidance of drug use. Instant messaging services can be instrumental in providing the social and educational support needs of individuals recovering from OUD.
Development of a Conversational Agent for Individuals Ambivalent About Quitting Smoking: Protocol for a Proof-of-Concept Study
Authors: Nair Uma S , Greene Karah , Marhefka Stephanie , Kosyluk Kristin , Galea Jerome T 
Published: January 2023

Background
Cigarette smoking is the leading preventable cause of disease and death in the United States. Despite the availability of a plethora of evidence-based smoking cessation resources, less than one-third of individuals who smoke seek cessation services, and individuals using these services are often those who are actively contemplating quitting smoking. There is a distinct dearth of low-cost, scalable interventions to support smokers not ready to quit (ambivalent smokers). Such interventions can assist in gradually promoting smoking behavior changes in this target population until motivation to quit arises, at which time they can be navigated to existing evidence-based smoking cessation interventions. Conversational agents or chatbots could provide cessation education and support to ambivalent smokers to build motivation and navigate them to evidence-based resources when ready to quit.

Objective
The goal of our study is to test the proof-of-concept of the development and preliminary feasibility and acceptability of a smoking cessation support chatbot.

Methods
We will accomplish our study aims in 2 phases. In phase 1, we will survey 300 ambivalent smokers to determine their preferences and priorities for a smoking cessation support chatbot. A “forced-choice experiment” will be administered to understand participants’ preferred characteristics (attributes) of the proposed chatbot prototype. The data gathered will be used to program the prototype. In phase 2, we will invite 25 individuals who smoke to use the developed prototype. For this phase, participants will receive an overview of the chatbot and be encouraged to use the chatbot and engage and interact with the programmed attributes and components for a 2-week period.

Results
At the end of phase 1, we anticipate identifying key attributes that ambivalent smokers prefer in a smoking cessation support chatbot. At the end of phase 2, chatbot acceptability and feasibility will be assessed. The study was funded in June 2022, and data collection for both phases of the study is currently ongoing. We expect study results to be published by December 2023.

Conclusions
Study results will yield a smoking behavior change chatbot prototype developed for ambivalent smokers that will be ready for efficacy testing in a larger study.

International Registered Report Identifier (IRRID)
DERR1-10.2196/44041
Health System–Level Barriers to Living Donor Kidney Transplantation: Protocol for a Comparative Case Study Analysis
Authors: Horton Anna , Loban Katya , Nugus Peter , Fortin Marie-Chantal , Gunaratnam Lakshman , Knoll Greg , Mucsi Istvan , Chaudhury Prosanto , Landsberg David , Paquet Michel , Cantarovich Marcelo , Sandal Shaifali 
Published: January 2023

Background
Living donor kidney transplantation (LDKT) is the best treatment option for patients with kidney failure and offers significant medical and economic advantages for both patients and health systems. Despite this, rates of LDKT in Canada have stagnated and vary significantly across Canadian provinces, the reasons for which are not well understood. Our prior work has suggested that system-level factors may be contributing to these differences. Identifying these factors can help inform system-level interventions to increase LDKT.

Objective
Our objective is to generate a systemic interpretation of LDKT delivery across provincial health systems with variable performance. We aim to identify the attributes and processes that facilitate the delivery of LDKT to patients, and those that create barriers and compare these across systems with variable performance. These objectives are contextualized within our broader goal of increasing rates of LDKT in Canada, particularly in lower-performing provinces.

Methods
This research takes the form of a qualitative comparative case study analysis of 3 provincial health systems in Canada that have high, moderate, and low rates of LDKT performance (the percentage of LDKT to all kidney transplantations performed). Our approach is underpinned by an understanding of health systems as complex adaptive systems that are multilevel and interconnected, and involve nonlinear interactions between people and organizations, operating within a loosely bounded network. Data collection will comprise semistructured interviews, document reviews, and focus groups. Individual case studies will be conducted and analyzed using inductive thematic analysis. Following this, our comparative analysis will operationalize resource-based theory to compare case study data and generate explanations for our research question.

Results
This project was funded from 2020 to 2023. Individual case studies were carried out between November 2020 and August 2022. The comparative case analysis will begin in December 2022 and is expected to conclude in April 2023. Submission of the publication is projected for June 2023.

Conclusions
By investigating health systems as complex adaptive systems and making comparisons across provinces, this study will identify how health systems can improve the delivery of LDKT to patients with kidney failure. Our resource-based theory framework will provide a granular analysis of the attributes and processes that facilitate or create barriers to LDKT delivery across multiple organizations and levels of practice. Our findings will have practice and policy implications and help inform transferrable competencies and system-level interventions conducive to increasing LDKT.

International Registered Report Identifier (IRRID)
DERR1-10.2196/44172
Comorbidities and New Onset of Type 2 Diabetes Mellitus among Women Living with HIV Receiving Antiretroviral Therapy in Lagos, Nigeria
Authors: Enya Veronica Nnenna Victor , Enabulele Onaiwu Idahosa , Ophori Endurance Anthony , Nonyelum Odunukwe Nkiruka 
Published: January 2023

Background: There is limited gender stratified data in many type 2 diabetes mellitus (T2DM) studies in Africa. This study aimed to determine the prevalence of Comorbidities, New Onset of T2DM and risk factors influencing predisposition to T2DM among women living with HIV (WLWH) and receiving Antiretroviral Therapies.

Methods: This was a cross-sectional study of females who were 15 years and above with HIV and/or without pulmonary TB attending HIV and TB DOTS clinics in Lagos, Nigeria from January 2019 to October 2021. The socio-demographic data of participants were obtained using questionnaire. Participants who were not known diabetic cases were tested for diabetes based on WHO and ADA standards using glycated haemoglobin (HbA1c) test, fasting plasma glucose and 2 hour 75 g oral glucose post prandial test. CD4 and CD8 counts were carried out using flow cytometer and their cytokines’ levels were determine using ELISA technique. HIV positive patients with signs and symptoms of TB (presumptive TB) were tested using sputum smear microscopy method and gene X-pert technique. We measured Body mass index (BMI) using International System of Units (kg/m2). Information on age, gender, Antiretroviral therapy (ART), values of CD4, weight, height, viral load and cholesterol test results less than 6 months were obtained from the patients’ folders.

Results: A total of 187 WLWH were studied. Their mean age was 41.93±10.32 years. Fifty-five (27.9%) had BMI values of ≥ 30 kg/m2. Twenty-one (11.2%) had impaired glucose level. Those with T2DM at baseline were 5(2.7%), 17(9.1%) later developed T2DM. There was strong association between newly developed T2DM and obesity odd ratio (OR) 8.21(95% CI 1.30-51.99), interleukin (IL-): IL-6 OR 4.50 (95% CI 0.58-35.15), viral load with OR as 1.34(0.48-3.75), knowledge of diabetes OR 2.24 (95% CI 0.43-11.62), consumption of alcohol OR 2.03(95% CI 0.60-6.90). Twenty (10.7%) WLWH developed pulmonary TB while receiving ART. Co-morbidities recorded were: HIV/T2DM 14(7.5%), HIV/TB 21(11.2%), HIV/TB/T2DM 7(3.7%). A total of 42(22.7%) were on 2nd line ART.

Conclusion: Prevalence of HIV/TB co-infection, HIV/T2DM comorbidity and HIV/TB/T2DM multimorbidity were high. Also the prevalence of incident TB and new cases of T2DM among the study population were high. There was positive association between development of T2DM while receiving ART and obesity, IL-6, knowledge of diabetes and alcohol consumption. Protease inhibitors were found to influence the development of T2DM among WLWH while receiving ART.

Recommendation: There is need for promoting awareness of T2DM and its risk factors among WLWH who are receiving ART.
INQUIRY BASED LEARNING MODULE BASED ON SCIENCE OBJECT MATERIAL AND OBSERVATION OF ODD SEMESTER GRADE VII OF SMP/MTS
Authors: YOLANDA REVA , Hardeli Hardeli 
Published: January 2023

ABSTRACT
This research discussed the Development of Inquiry Based Learning Module Based on Science Object Material and Observation of Odd Semester Grade VII of SMPN 13 Padang. This study aims to produce inquiry-based modules that can help students increase their interest in learning and independent learning in understanding subject matter, as well as investigating validity and practicality. This type of the research is the Ploomp development model which consists of three stages, namely preliminary research, prototype stage, and assessment phase. The research instrument was a questionnaire. The Observation was validated by a validator consisting of 2 lecturers at the Natural Sciences of UNP, and 2 science teachers at SMPN 13 Padang. The Practicality Test was conducted by science teachers and students of class VII at SMPN 13 Padang. Based on the results of the research conducted, an inquiry based learning module was obtained. The Product research by teachers based on the average ease of use of validity ,the efficiency of learning time and the benefits of using validity module are very high. The Product research by students based on average ease is very high.
© Department of Science Education, Universitas Negeri Padang
Keywords: module, the object of natural science and its observations, and inquiry based learning.
ANALISIS TINGKAT KEBERMANFAATAN MYPERTAMINA MENGGUNAKAN K-MEANS CLUSTERING
Authors: Kharisma Kharisma , Aesyi Ulfi Saidata 
Published: January 2023

Pertamina, menerapkan digitalisasi Stasiun Pengisian Bahan Bakar Umum (SPBU) melalui aplikasi mypertamina yang bekerja sama dengan linkaja. Meskipun aplikasi tersebut menawarkan beberapa program yang dapat mempermudah pelanggan, ternyata masyarakat banyak mengomentari aplikasi tersebut sehingga menyebabkan topik mypertamina di twitter menjadi trending topik pada bulan Juli. Akan tetapi komentar tersebut tidak seluruhnya positif. Komentar yang terlalu banyak tentang aplikasi mypertamina ini, menyebabkan sulitnya berbagai kalangan untuk menyimpulkan tingkat kebermanfaatan dari aplikasi tersebut, termasuk pertamina. Sehingga diperlukan penelitian untuk menganalisis tingkat kebermanfaatan aplikasi mypertamina dari banyaknya komentar masyarakat di twitter.Oleh karena itu, penelitian ini mengumpulkan data berupa tweet masyarakat dari twitter tentang aplikasi mypertamina. Data tersebut kemudian dibersihkan dan dihitung kedekatan aktanya menggunakan TF-IDF. Setelah itu data dikelompokkan dengan menggunakan K-Means. Dengan menggunakan coherence score, kluster terbaik ada di kluster 2. Kluster 0 berisi kata keluhan masyarakat terhadap aplikasi my pertamina. Kluster 1 berisi kata umum terkait aplikasi pertamina. Berdasarkan analisis hasil kluster yang diperoleh, maka aplikasi mypertamia mendapatkan banyak keluhan dari masyarakat yang cenderung berpendapat bahwa aplikasi mypertamina tidak bermanfaat untuk masyarakat.
Kata Kunci :
mypertamina, datamining, klustering, K-Means
Superficial anatomic landmarks can be used to triangulate the location of canine peripheral lymphocentrums: superficial cervical, axillary, and superficial inguinal
Authors: Worden Natalie J. , Bertran Judith , Watt Meghan M. , Reynolds Penny S. , de Mello Souza Carlos H. , Maxwell Elizabeth A. , Adin Christopher A. , Ham Kathleen , Regier Penny J. 
Published: January 2023

Abstract

OBJECTIVE
To utilize the geometry of superficial anatomic landmarks to guide incisional location and orientation for peripheral lymphadenectomy, document deep anatomic landmarks for lymphocentrum identification, and develop novel surgical approaches to the superficial cervical, axillary, and superficial inguinal lymphocentrums in dogs.

ANIMALS
12 canine cadavers.

PROCEDURES
2 cadavers were used for a pilot investigation to determine optimal body positioning, select superficial anatomic landmarks for lymphocentrum identification, and evaluate novel surgical approaches to the 3 lymphocentrums. These lymphocentrums were then dissected in 10 additional cadavers using these novel surgical approaches. Measurements of the distances from lymphocentrum to landmark and between landmarks were obtained for each lymphocentrum. Deep anatomic landmarks were recorded for each dissection. The mean and SD were calculated for each measurement and used to develop geometric guidelines for estimating the location of each lymphocentrum for these surgical approaches.

RESULTS
Each peripheral lymphocentrum was found in the same location relative to the respective, predetermined, superficial, anatomic boundaries in all cadavers. Briefly, the superficial landmarks to each lymphocentrum were as follows: (1) superficial cervical: wing of atlas, acromion process of scapula, greater tubercle of humerus; (2) axillary: caudal border of transverse head of superficial pectoral muscle, caudal triceps muscle, ventral midline; and (3) superficial inguinal: origin of pectineus muscle, ipsilateral inguinal mammary gland, ventral midline. The proposed superficial and deep surgical landmarks were identified within every cadaver. The previously undescribed surgical approaches were effective for lymphocentrum identification.

CLINICAL RELEVANCE
Anatomic landmarks provided in this study may help reduce surgical time and tissue trauma during peripheral lymphadenectomy in dogs. This study was also the first to describe a surgical approach to the superficial inguinal lymphocentrum and ventral approaches to the superficial cervical and axillary lymphocentrums and provided previously unpublished anatomic landmarks for a lateral approach to the superficial cervical lymphocentrum.
Electrocardiographic findings in healthy Cavalier King Charles Spaniels, Pugs, and English Bulldogs
Authors: Romito Giovanni , Castagna Prisca , Sabetti Maria Chiara , Cipone Mario 
Published: January 2023

Abstract

OBJECTIVE
To describe the ECG findings in 3 different canine brachycephalic breeds: the Cavalier King Charles Spaniel, the Pug, and the English Bulldog (EB).

ANIMALS
135 healthy dogs (50 Cavalier King Charles Spaniels, 50 Pugs, and 35 EBs).

PROCEDURES
Medical records were retrospectively reviewed to identify healthy dogs ≥ 1 year old that had undergone an ECG. The Mann-Whitney U test or the Student t test were used to compare continuous variables between male and female dogs, whereas the χ2 test was used for categorical variables. Spearman correlation coefficients between ECG measurements and age and body weight were also calculated in the case of continuous variables, whereas the Kruskal-Wallis test was used for categorical ones.

RESULTS
Electrocardiographic parameters of healthy Cavalier King Charles Spaniels overall fitted with traditional reference intervals cited in textbooks; in contrast, 28% of Pugs and 20% of EBs showed a shift of the QRS-complex mean electrical axis (QRS-MEA). In Pugs and EBs, the mean/median QRS-MEA value was 56° (from 0° to 100°) and 59° (from 20° to 100°), respectively. All axis shifts were left shifts (in Pugs, from 0° to 34°; in EBs, 20° to 39°). Only a few meaningful differences were found when comparing ECG variables between males and females. Similarly, only 1 statistically significant correlation was found between ECG parameters and age and body weight.

CLINICAL RELEVANCE
Healthy Pugs and EBs present a trend to a left shift of the QRS-MEA. This should be considered when interpreting ECG tracings in these breeds.
Prospects of DNA microarray application in management of chronic obstructive pulmonary disease: A systematic review
Authors: Anastasiia Litvinova , Ilia Bykov 
Published: January 2023

Abstract
Chronic obstructive pulmonary disease (COPD) is incurable chronic disease which kills 3.3 million each year worldwide. Number of global cases of COPD is steadily rising alongside with life expectancy, disproportionally hitting middle-income countries like Russia and China, in such conditions, new approaches to the COPD management are desperately needed. DNA microarray technology is a powerful genomic tool that has the potential to uncover underlying COPD biological alteration and brings up revolutionized treatment option to clinicians. We executed systematic review studies of studies published in last 10 years regarding DNA microarray application in COPD management, with complacence to PRISMA criteria and using PubMed and Medline data bases as data source. Out of 920 identified papers, 39 were included in the final analysis. We concluded that Genome-wide expression profiling using DNA microarray technology has great potential in enhancing COPD management. Current studied proofed this method is reliable and possesses many potential applications such as individual at risk of COPD development recognition, early diagnosis of disease, COPD phenotype identification, exacerbation prediction, personalized treatment optioning and prospect of oncogenesis evaluation in patients with COPD. Despite all the proofed benefits of this technology, researchers are still in the early stage of exploring it's potential. Therefore, large clinical trials are still needed to set up standard for DNA microarray techniques usage implementation in COPD management guidelines, subsequently giving opportunity to clinicians for controlling or even eliminating COPD entirely.
Research progress on adaptive modifications of the gut microflora and regulation of host glucose and lipid metabolism by cold stimulation
Authors: Wei Wanting , Zhang Guanyu , Zhang Yongqiang , Zhang Li , Wu Shuai , Li Xi , Yang Danfeng 
Published: January 2023

Abstract
The gut microflora is a combination of all microbes in intestine and their microenvironment, and its change can sensitively reflect the relevant response of the body to external environment and remarkably affect body's metabolism as well. Recent studies have found that cold exposure affects the body's gut microflora, which can lead to changes in the body's metabolism of glucose and lipid. This review summarizes recent research on the effects of cold exposure on gut microbes and metabolism of glucose and lipid, aiming to provide some new ideas on the approaches and measures for the prevention and treatment of diabetes and obesity.
Cold weather and Kashin-Beck disease
Authors: Wang Kewei , Yu Jun , Sun Dianjun 
Published: January 2023

Abstract
Kashin-Beck disease (KBD) is an endemic osteoarthropathy. Its distribution region covers a long and narrow belt on the Pacific side and belongs to continental climate with short summer, long frost period, and large temperature differences between day and night. In particular, KBD patients are typically scattered in the rural areas with seasonal features such as cold winters and rainy autumns. Etiological studies have demonstrated that the carrier of pathogenic factors is the grains produced in endemic areas. Risk factors for KBD include fungal contamination of grains due to poor storage conditions associated with cold weather. The epidemiological characteristics of KBD include agricultural area, early age of onset, gender equality, family aggregation, regional differences, and annual fluctuations. A series of preventive measures have been successfully taken in the past decades. National surveillance data indicate that the annual incidence of KBD is gradually declining.