bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of safety, effectiveness and treatment patterns of sodium zirconium cyclosilicate in management of hyperkalaemia in China: a real-world study protocol
Authors: Shen Nan , Meng Qingyang , Zhang Lihong , Xie Hua , Zhao Jianrong , Xing Changying , Zuo Li , Long Gang , Zhu Qiang , Shan Chunyan , Cai Xudong , Yang Jing , Luo Xun , Wang Jianmin , Ye Jianming , Wan Xin , Tian Shaojiang , Wu Yifan , Lin Yongqiang , Yu Xiaoyong , Li Qing , Liu Xinyu , Shi Zhenwei , Zhou Jingwei , Liu Chunyan , Cao Yanping , Wang Niansong , Jiang Xinxin , Wu Henglan , Hu Yao , Li Lu , Wang Zhaohua , He Jingdong , Cao Juan , Wu Fenglei , Ma Cong , Yin Xun , Li Zhongxin , Wang Huimin , Lin Hongli 
Published: May 2023

IntroductionHyperkalaemia (HK) is a potentially life-threatening electrolyte imbalance associated with several adverse clinical outcomes. The efficacy and negative effects of currently existing treatment options have made HK management questionable. Sodium zirconium cyclosilicate (SZC), a novel highly selective potassium binder, is approved for the treatment of HK. The present study will be aimed to assess the safety, effectiveness and treatment patterns of SZC in Chinese patients with HK in a real-world clinical setting as it is required by China’s drug review and approval process.Methods and analysisThis is a multicentre, prospective cohort study which plans to enrol 1000 patients taking SZC or willing to take SZC from approximately 40 sites in China. Patients ≥18 years of age at the time of signing the written informed consent and with documented serum potassium levels ≥5.0 mmol/L within 1 year before study enrolment day will be included. Eligible patients will receive SZC treatment and will be followed up for 6 months from enrolment day. The primary objective will be to evaluate the safety of SZC for the management of HK in Chinese patients in terms of adverse events (AEs), serious AEs as well as discontinuation of SZC. The secondary objectives will include understanding the SZC dosage information in terms of its effectiveness and treatment patterns under real-world clinical practice and assessing effectiveness of SZC during the observational period.Ethics and disseminationThis study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Dalian Medical University (approval number: YJ-JG-YW-2020). All the participating sites have received the ethics approval. Results will be disseminated through national and international presentations and peer-reviewed publications.Trial registration numberNCT05271266.
Light chain only variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a clinicopathological study of three cases
Authors: Liang Shaoshan , Liang Dongmei , Zhu Xiaodong , Liang Dandan , Xu Feng , Tu Yuanmao , Zeng Caihong 
Published: May 2023

AimsTo explore the clinical and pathological features of light chain only variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID-LC).MethodsFrom January 2010 to December 2022, patients who were diagnosed with PGNMID-LC were selected, and their clinical and pathological features were retrospectively analysed.ResultsThree males aged 42–61 years old were enrolled. Hypertension was present in three patients, oedema in three patients, anaemia in two patients, proteinuria in three patients, nephrotic syndrome in one patient, microscopic haematuria in three patients, renal insufficiency in two patients and hypocomplementaemia of C3 in one patient. Elevated serum-free LC ratios and plasmacytosis on bone marrow smears were observed in three patients, and κ was identified by serum protein immunofixation electrophoresis in one patient. Renal biopsy showed membranoproliferative glomerulonephritis in two patients and endocapillary proliferative glomerulonephritis in one patient on light microscopy. Immunofluorescence indicated restricted κ LC and C3 distributed in glomeruli. By electron microscopy, electron-dense deposits without substructure were identified predominantly in the mesangial and subendothelial regions and were variable in the subepithelial region. Two patients were treated with plasma cell-directed chemotherapy and achieved haematological complete response or very good partial response, and one of them achieved a renal status of complete remission. One patient treated with immunosuppressive therapy only did not achieve haematological or renal remission.ConclusionsPGNMID-LC is a rare and uniform disease with a high frequency of a detectable pathogenic plasma cell clone and is characterised by glomerular deposition of restricted LC and C3 in renal pathology. Plasma cell-directed chemotherapy may improve haematological and renal prognosis.
Night work and breast cancer risk in a cohort of female healthcare employees in Stockholm, Sweden
Authors: Gustavsson Per , Bigert Carolina , Andersson Tomas , Kader Manzur , Härmä Mikko , Selander Jenny , Bodin Theo , Albin Maria 
Published: May 2023

ObjectivesNight work has been classified as probably carcinogenic to humans by the International Agency for Research on Cancer, but epidemiological evidence was considered limited due to variability in findings and potential bias. This study aimed to investigate the risk of breast cancer in a cohort with detailed and registry-based data on night work.MethodsThe cohort comprised 25 585 women (nurses and nursing assistants) employed 1 year or more between 2008 and 2016 in the healthcare sector in Stockholm. Information on work schedules was obtained from employment records. Breast cancer cases were identified from the national cancer register. HRs were estimated by a discrete time proportional hazards model, adjusting for age, country of birth, profession and childbirth.ResultsThere were 299 cases of breast cancer, 147 in premenopausal and 152 in postmenopausal women. The adjusted HR of postmenopausal breast cancer in association with ever versus never working nights was 1.31 (95% CI 0.91 to 1.85). Eight or more years of night work was associated with an increased risk of postmenopausal breast cancer, HR=4.33 (95% CI 1.45 to 10.57), based on five cases only, though.ConclusionsThis study is limited by a short period of follow-up and a lack of information on night work before 2008. Most exposure metrics showed no association with breast cancer risk, but there was an elevated risk of postmenopausal breast cancer in women after 8 or more years of night work.
Detailed phenotype ofRNF213p.R4810K variant identified by the Chinese patients with acute ischaemic stroke or transient ischaemic attack
Authors: Zhou Hongyu , Jing Jing , Pu Yuehua , Li Wei , Meng Xia , Wang Anxin , Zuo Yingting , Xu Zhe , Xu Qin , Suo Yue , Li Hao , Wang Yongjun 
Published: May 2023

Background and purposeThe ring finger protein 213 gene (RNF213) p.R4810K variant increased the risk of acute ischaemic stroke (AIS) attributable to intracranial arterial stenosis (ICAS) in the Japanese and Korean populations. In this study, we aimed to examine the prevalence of theRNF213p.R4810K variant in Chinese patients with AIS or transient ischaemic attack and identify the phenotype of the carriers.MethodsWe analysed data from the Third China National Stroke Registry. All included participants were divided into two groups by carrier status of the p.R4810K variant. The aetiological classification was conducted according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. The presence of ICAS and extracranial arterial stenosis (ECAS) was defined as 50%–99% stenosis or occlusion of any intracranial and extracranial artery. Logistic regression models and Cox regression models were used to evaluate the association of the p.R4810K variant with TOAST classification, stenosis phenotypes and clinical outcomes.ResultsA total of 10 381 patients were enrolled, among which 56 (0.5%) had the heterozygote GA genotype for p.R4810K. The variant carriers were younger (p=0.01), and more likely to suffer from peripheral vascular disease (p=0.04). The p.R4810K variant was associated with large-artery atherosclerosis (LAA) (adjusted OR=1.94, 95% CI 1.13 to 3.33), anterior circulation stenosis (adjusted OR=2.12, 95% CI 1.23 to 3.65) and ECAS (adjusted OR=2.29, 95% CI 1.16 to 4.51). Nevertheless, the p.R4810K variant was not associated with recurrence, poor functional outcome and mortality at 3 months and 1 year.ConclusionsTheRNF213p.R4810K variant was associated with LAA, anterior circulation stenosis and ECAS in Chinese patients. Given the low carrying rate and only 1-year follow-up information, caution should be taken to interpret our findings in no statistically significant association between the p.R4810K variant and stroke prognosis in Chinese patients.
Prestroke physical activity is associated with admission haematoma volume and the clinical outcome of intracerebral haemorrhage
Authors: Viktorisson Adam , Buvarp Dongni , Danielsson Anna , Skoglund Thomas , S Sunnerhagen Katharina 
Published: May 2023

BackgroundPrestroke physical activity (PA) has been linked to improved outcomes after intracerebral haemorrhage (ICH), but its association with ICH volume is unknown. We aimed to investigate associations of prestroke PA with location-specific haematoma volume and the clinical outcome of ICH.MethodsAll patients with primary ICH, admitted to three hospitals between 2014 and 2019, were included. Patients performing light PA ≥4 hour/week the year before stroke were considered physically active. Haematoma volumes were assessed from admission brain imaging. Adjusted associations were estimated using multivariate linear and logistic regression models. Haematoma volume was explored as mediator to the relationship between prestroke PA and mild stroke severity (0–4 points on the National Institutes of Health Stroke Scale), a good 1-week functional status (0–3 points on the modified Rankin Scale) and 90-day survival. Average direct effects (ADE) and average causal mediation effects (ACME) were computed.ResultsOf 686 primary ICH cases, 349 were deep, 240 lobar and 97 infratentorial. Prestroke PA predicted smaller haematoma volumes in deep ICH (β=−0.36, SE=0.09, p<0.001) and lobar ICH (β=−0.23, SE=0.09, p=0.016). Prestroke PA was also associated with mild stroke severity (OR 2.53, 95% CI 1.59 to 4.01), a good 1-week functional status (OR 2.12, 95% CI 1.37 to 3.30) and 90-day survival (OR 3.48, 95% CI 2.06 to 5.91). Haematoma volume partly mediated the relationships between PA and stroke severity (ADE 0.08, p=0.004; ACME 0.10, p<0.001), 1-week functional status (ADE 0.07, p=0.03; ACME 0.10, p<0.001) and 90-day survival (ADE 0.14, p<0.001; ACME 0.05, p<0.001).ConclusionsLight PA ≥4 hour/week prior to ICH was associated with smaller haematoma volumes in deep and lobar locations. Physically active patients with ICH had a higher likelihood of mild stroke, a good 1-week functional status and 90-day survival, in part mediated by smaller haematoma volumes on admission.
A comprehensive content analysis of 104 Chinese electronic cigarette manufacturing enterprise official websites
Authors: Deng Hui , Fang Ling , Zhang Lingyun , Yan Xiaotao , Wang Fan , Hao Xinyu , Zheng Pinpin 
Published: May 2023

Objective
The goal was to analyse website content of Chinese electronic (e) cigarette manufacturing enterprises and understand the marketing strategies to provide evidence for decision-makers to regulate manufacturers.

Methods
Through QCC.com, one of the largest enterprise information query platforms in China, we identified 104 official manufacturer websites in 2021. A codebook including 6 sections with 31 items was developed and all webpages were coded separately by two trained researchers.

Results
Over half of the websites (56.7%) did not have age verification for entry. Thirty-two (30.8%) websites had no restriction for minors to use or purchase e-cigarettes, and 79 (76.0%) had no health warning. Overall, 99 websites (95.2%) displayed their products, and 72 (69.2%) displayed e-flavours. The most frequently used descriptions of products included good taste (68.3%), positive mood (62.5%), leakage resistance (56.7%), enjoyment (47.1%), reduced harm (45.2%), alternatives to cigarettes (43.3%) and long battery life (42.3%). Additionally, 75 websites (72.1%) provided contact information on different channels, including WeChat (59.6%), Weibo (41.3%), Facebook (13.5%), Instagram (12.5%) and brand apps (2.9%). Manufacturers provided investment and franchise information (59.6%) and offline store information (17.3%). In addition, 41.3% websites included content regarding corporate social responsibility.

Conclusions
Chinese e-cigarette manufacturers’ official websites have become a platform for presenting product and brand information, establishing online and offline marketing loops, and displaying corporate social responsibility with weak age restrictions on access and a lack of health warnings. The Chinese government should implement strict regulatory measures on e-cigarette enterprises.
Older age is associated with greater misperception of the relative health risk of e-cigarettes and cigarettes among US adults who smoke
Authors: Rubenstein Dana , Denlinger-Apte Rachel L , Cornacchione Ross Jennifer , Carroll Dana Mowls , McClernon F Joseph 
Published: May 2023

IntroductionThe prevalence of cigarette smoking among adults aged ≥55 has remained stagnant over the past decade. National data modelling suggests no reduction in cigarette smoking prevalence attributable to e-cigarette use in the USA among people aged ≥45. Misperceptions about the absolute risks (ie, cigarettes are not harmful) and relative risks (ie, e-cigarettes are more harmful than cigarettes) of tobacco products may contribute to sustained smoking prevalence and hesitancy to switch from cigarettes to e-cigarettes among older adults.MethodsParticipants reported cigarette use (n=8072) at Wave 5 (2018–2019) of the Population Assessment of Tobacco and Health Study. Weighted multivariable logistic regressions included six age categories (independent variable) and cigarette and e-cigarette risk perceptions (outcomes). Additional models assessed the associations between dichotomous age (≥55 vs 18–54), risk perceptions and an interaction term (independent variables) with past 12-month quit attempts and past-month e-cigarette use (outcomes).ResultsAdults aged ≥65 were less likely than adults aged 18–24 to rate cigarettes as very/extremely harmful (p<0.05). Odds of rating e-cigarettes as more harmful than cigarettes among adults aged 55–64 and ≥65 were 1.71 (p<0.001) and 1.43 (p=0.024) greater than for adults aged 18–24. This misperception was negatively associated with past-month e-cigarette use and was stronger among adults aged ≥55 (p<0.001) than adults aged <55 (p<0.001).DiscussionAdults aged ≥55 are more likely to have misperceptions about the absolute and relative risks of tobacco products, which may contribute to continued smoking. Health communications targeting this age group could modify beliefs about the perceived harms of tobacco products.
Massive particle pair production and oscillation in Friedman Universe: reheating energy and entropy, and cold dark matter
Authors: Xue She-Sheng 
Published: May 2023

AbstractSuppose that the early Universe starts with a cosmological $$\Lambda $$
Λ
-term (dark energy) originating from quantum spacetime at the Planck scale. Dark energy drives inflation and reheating by reducing its value for massive particle–antiparticle pairs production and oscillation, resulting in a holographic and massive pair plasma state. The back-and-forth reaction of dark energy and massive pairs slows inflation to its end and starts reheating by rapidly producing stable and unstable pairs. We introduce the Boltzmann-type rate equation describing the back-and-forth reaction. It forms a close set with Friedman equations and reheating equations for unstable pairs decay to relativistic particles. The numerical solutions show preheating, massive pairs dominated and genuine reheating episodes. We obtain the reheating temperature and entropy in terms of the tensor-to-scalar ratio $$0< r < 0.047$$

0
<
r
<
0.047

consistently with observations. Stable massive pairs represent cold dark matter particles and weakly interact with dark energy. The resultant cold dark matter abundance $$\Omega _c\sim 10^{-1}$$

Ω
c

∼

10

-
1

is about a constant in time.
Development of an Anti-canine PD-L1 Antibody and Caninized PD-L1 Mouse Model as Translational Research Tools for the Study of Immunotherapy in Humans
Authors: Oh Wonkyung , Kim Alyssa Min Jung , Dhawan Deepika , Kirkham Perry M. , Ostafe Raluca , Franco Jackeline , Aryal Uma K. , Carnahan Robert H. , Patsekin Valery , Robinson J. Paul , Knapp Deborah W. , Lim Seung-Oe 
Published: May 2023

Immune checkpoint blockade therapy, one of the most promising cancer immunotherapies, has shown remarkable clinical impact in multiple cancer types. Despite the recent success of immune checkpoint blockade therapy, however, the response rates in patients with cancer are limited (∼20%–40%). To improve the success of immune checkpoint blockade therapy, relevant preclinical animal models are essential for the development and testing of multiple combination approaches and strategies. Companion dogs naturally develop several types of cancer that in many respects resemble clinical cancer in human patients. Therefore, the canine studies of immuno-oncology drugs can generate knowledge that informs and prioritizes new immuno-oncology therapy in humans. The challenge has been, however, that immunotherapeutic antibodies targeting canine immune checkpoint molecules such as canine PD-L1 (cPD-L1) have not been commercially available. Here, we developed a new cPD-L1 antibody as an immuno-oncology drug and characterized its functional and biological properties in multiple assays. We also evaluated the therapeutic efficacy of cPD-L1 antibodies in our unique caninized PD-L1 mice. Together, these in vitro and in vivo data, which include an initial safety profile in laboratory dogs, support development of this cPD-L1 antibody as an immune checkpoint inhibitor for studies in dogs with naturally occurring cancer for translational research. Our new therapeutic antibody and caninized PD-L1 mouse model will be essential translational research tools in raising the success rate of immunotherapy in both dogs and humans.

Significance:
Our cPD-L1 antibody and unique caninized mouse model will be critical research tools to improve the efficacy of immune checkpoint blockade therapy in both dogs and humans. Furthermore, these tools will open new perspectives for immunotherapy applications in cancer as well as other autoimmune diseases that could benefit a diverse and broader patient population.
Surging Biojustice Environmentalism from Below: Hope for Ending the Earth System Emergency?
Authors: Dauvergne Peter , Clapp Jennifer 
Published: May 2023

AbstractGlobal environmental politics is at a critical juncture as the Earth System emergency deepens. The core environmental policies and actions of governments, intergovernmental organizations, corporations, and, to a lesser extent, mainstream nongovernmental organizations are visibly failing to deescalate this emergency. In response to these failures, we argue, dispossessed individuals, Indigenous peoples, grassroots activists, and civil society campaigners are joining forces to challenge market-liberal and institutionalist thinking and initiate new ways of organizing political and social life that prioritize biological integrity and social justice: what we describe as “biojustice environmentalism from below.” Global environmental governance, meanwhile, is at a crossroads, becoming increasingly polycentric as biojustice environmentalism surges and as corporations seek to capture governance spaces through multistakeholder initiatives. How surging biojustice environmentalism in a polycentric governance landscape plays out in the coming years, we conclude, will be crucial for humanity’s ability to stem the escalating global environmental crisis.
Reproducible science of science at scale:
pySciSci
Authors: Gates Alexander J. , Barabási Albert-László 
Published: May 2023

Abstract
Science of science (SciSci) is a growing field encompassing diverse interdisciplinary research programs that study the processes underlying science. The field has benefited greatly from access to massive digital databases containing the products of scientific discourse—including publications, journals, patents, books, conference proceedings, and grants. The subsequent proliferation of mathematical models and computational techniques for quantifying the dynamics of innovation and success in science has made it difficult to disentangle universal scientific processes from those dependent on specific databases, data-processing decisions, field practices, etc. Here we present pySciSci, a freely available and easily adaptable package for the analysis of large-scale bibliometric data. The pySciSci package standardizes access to many of the most common data sets in SciSci and provides efficient implementations of common and advanced analytical techniques.
Reconstructing variation in Indo-European word order
Authors: Biagetti Erica , Inglese Guglielmo , Zanchi Chiara , Luraghi Silvia 
Published: May 2023

Abstract
Word order is a central issue in the reconstruction of Proto-Indo-European syntax. Categorical approaches have proved to be inadequate because they postulate for the protolanguage a typological consistency which is absent in any of the attested daughter languages. Following recent research, we adopt a gradient approach to word order, which treats word order preferences as a continuous variable. We analyze four word order patterns based on data extracted from treebanks of ancient Indo-European languages. After presenting our results for AdpN/NAdp, GN/NG, AN/NA, and OV/VO, we draw a number of conclusions concerning variation within individual languages, crosslinguistic variation, and variation in diachrony that support the claim that variability should be taken as the normal state across languages, including reconstructed stages. We conclude that a non-discrete approach has the advantage of leading to a reconstruction that better conforms to the situation known from real languages, with variation as a key feature.