bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictive value of deep learning-based cardiac ultrasound flow imaging for hypertrophic cardiomyopathy complicating arrhythmias
Authors: Wu Haotang , Huang Zhiyong , Liu Juanjuan , Dai Jiancheng , Zhao Yong , Luo Weiquan 
Published: January 2023

Abstract
Objective
To investigate the predictive value of deep learning-based cardiac ultrasound flow imaging for hypertrophic cardiomyopathy (HCM) complicated by arrhythmias.

Methods
The clinical data of 158 patients with hypertrophic cardiomyopathy were retrospectively collected from July 2019 to December 2021, and additionally divided into training group 106 cases, validation group 26 cases and test group 26 cases according to the ratio of 4:1:1, and divided into concurrent and non-concurrent groups according to whether they were complicated by arrhythmia or not, respectively. General data of patients (age, gender, BMI, systolic blood pressure, diastolic blood pressure, HR) were collected, a deep learning model for cardiac ultrasound flow imaging was established, and image data, LVEF, LAVI, E/e', vortex area change rate, circulation intensity change rate, mean blood flow velocity, and mean EL value were extracted.

Results
The differences in general data (age, gender, BMI, systolic blood pressure, diastolic blood pressure, HR) between the three groups were not statistically significant, P > 0.05. The differences in age, gender, BMI, systolic blood pressure, diastolic blood pressure, HR between the patients in the concurrent and non-concurrent groups in the training group were not statistically significant, P > 0.05.

Conclusions
Deep learning-based cardiac ultrasound flow imaging can identify cardiac ultrasound images more accurately and has a high predictive value for arrhythmias complicating hypertrophic cardiomyopathy, and vortex area change rate, circulation intensity change rate, mean flow velocity, mean EL, LAVI, and E/e' are all risk factors for arrhythmias complicating hypertrophic cardiomyopathy.
Performance of CO2-Cured Alkali-Activated Slag Pastes During Curing and Exposure
Authors: Jun Yubin , Han Seong Ho , Kim Jae Hong 
Published: January 2023

AbstractThis study investigated the efficiency of CO2 curing in blast-furnace slag pastes activated with three concentrations of KOH solution (3, 4, and 5 M). The CO2 curing was applied into the alkali-activated slag paste for 3 days. The CO2-cured pastes were subjected to subsequent curing in a water bath or exposed to seawater. The mechanical properties and characteristics of the reaction products were compared. Full strength can be obtained within 3 days of the early CO2 curing. The strength remained almost constant regardless of the activator concentration. The CO2-cured samples produced more CaCO3 after exposure to the seawater. The carbonates filled the micropores of the samples, and no strength reduction was observed. The hydrates Ca(OH)2 and C–S–H(I) are carbonated, forming calcite and amorphous CaCO3 during the subsequent curing and exposure to seawater as well as the CO2 curing. A less dense matrix with a lower activator concentration facilitated the diffusion of CO2 and promoted early carbonation in the paste. The polymerization of C–S–H(I) was relatively slow with low activity, and within the period of CO2 curing, more carbonates were produced in the sample prepared at a low activator concentration.
Psychometric properties of the ORTO-R in a community-based sample of women and men from Poland
Authors: Brytek-Matera Anna , Obeid Sahar , Donini Lorenzo Maria , Rogoza Marta , Marchlewska Marta , Plichta Marta , Jezewska-Zychowicz Marzena , Hallit Souheil , Rogoza Radosław 
Published: January 2023

AbstractPurposeOver the past two decades, orthorexia nervosa (ON) has been increasingly investigated. Recently, a new revision version of the ORTO-15, namely ORTO-R, was used. The main objective of the present study was to confirm the factor structure of Polish version of the ORTO-R for evaluating ON thoughts and behaviors.MethodIn three studies, a total of 3081 participants was selected by random sampling through several universities and companies. In Study 1, we used original items of ORTO-15, in Study 2 we used both, the ORTO-15 items and the revised items from ORTO-R, and in Study 3 we used only the items from the ORTO-R. Confirmatory factor analysis was used for determining the factorial structure of the Polish version of the ORTO-R. We also assessed internal consistency and convergent and criterion validity of the ORTO-R.ResultsThe model composed of the revised items (ORTO-R) was characterized of good convergent and criterion validity. Furthermore, ORTO-R appeared to be more internally consistent as compared to ORTO-15.ConclusionThe 6-item ORTO-R is valid and reliable method to assess orthorexic thoughts and behaviors among Polish-speaking population and could be applied in future research. Using revised version of the items is strongly preferred to using the items in their original ORTO-15 form.
The psychological impact of COVID-19 in a socio-politically unstable environment: protective effects of sleep and gratitude in Lebanese adults
Authors: El Khoury-Malhame Myriam , Rizk Rana , Joukayem Esperance , Rechdan Alyssa , Sawma Toni 
Published: January 2023

Abstract
Background
The COVID-19 global pandemic initiated an unprecedented medico-psychological turmoil. Our study investigates the psychological impact of the viral spread and austere lockdown, and focuses mostly on potential protective factors in a politically and economically unstable society.

Methods
A cross-sectional design was used to evaluate rates of mental distress in a sample of 348 Lebanese adults. Participants filled questionnaires of perceived stress (PSS), depression (PHQ-9), anxiety (GAD-7), PTSD (IES-22), as well as sleep (PSQi) and gratitude (GQ-6) immediately after 3 months of strict quarantine. Demographics included gender, age, employment and infection statuses. Correlations and regression models were used.

Results
Results indicated a very high prevalence of mental distress, in addition to major alterations in sleep quality and quantity. Younger age and unemployment correlated with more severe symptoms. Sleep was found to be a protective factor against all studied psychological distress, and gratitude further mitigated effects of depression.

Conclusions
Mental health significantly degrades post-COVID lockdown, even in the absence of direct viral threat. Yet simple behavioral and cognitive changes like sleep and attitude of gratitude could provide protective factors against these psychological distresses. Such changes should be further explored and advocated as cost-efficient self-care practices to buffer this devastating public health burden, especially in unstable socio-political environments.
Digital characterization of the surface texture of chinese classical garden rockery based on point cloud visualization: small-rock mountain retreat
Authors: Yang Chen , Han Xiaorong , Wu Hangbin , Han Feng , Wei Chaoxu , Shutter Leigh 
Published: January 2023

Abstract
The Rockery is often a key element of a Classical Chinese Garden. It’s exquisite detailed physical characteristics a major contributor to artistic value, aesthetic appeal, and the carrier of historical and cultural heritage values. Poets and scholars have often described the beauty of these places in classical gardens in qualitative terms but lacked the quantitative tools to provide replicable metric descriptions. The highly complex forms and surfaces, irregularity, and fragility of garden rockeries has challenged authors to accurately describe the characteristics of these qualities using traditional methods and tools. This article presents a new method of digital characterization approach based on laser scanning and point cloud visualization, which can quantitatively detect and represent the pattern of rockery surface textures. It offers a replicable accurate quantitative descriptor of the Classical Chinese rockery. The Small-Rock Mountain Retreat, a nationally protected rockery garden in China, has been used as a case study. It contains original historic elements and more recently restored areas. Two characteristics of rockery surfaces, including the well-proportioned density and space, and the proper contrast between solid and void, were analyzed by examining four attributes: (1) surface complexity; (2) contour curvature; (3) shape variation; and (4) the interweaving of lightness and darkness. The findings demonstrate that, despite some similarities between the restored portion of the rockery and the historical remnants, there are variances in the richness of the details and the balanced distribution of shape change. The digital characterization approach introduced in this article offers a new perspective for recording and in turn safeguarding Chinese garden rockeries and other irregular cultural heritage objects.
Out of the blue: the independent activity of sulfur-oxidizers and diatoms mediate the sudden color shift of a tropical river
Authors: Arce-Rodríguez Alejandro , Libby Eduardo , Castellón Erick , Avendaño Roberto , Cambronero Juan Carlos , Vargas Maribel , Pieper Dietmar H. , Bertilsson Stefan , Chavarría Max , Puente-Sánchez Fernando 
Published: January 2023

Abstract
Background
Río Celeste (“Sky-Blue River”) is a river located in the Tenorio National Park (Costa Rica) that has become an important hotspot for eco-tourism due to its striking sky-blue color. A previous study indicated that this color is not caused by dissolved chemical species, but by formation of light-scattering aluminosilicate particles at the mixing point of two colorless streams, the acidic Quebrada Agria and the neutral Río Buenavista.

Results
We now present microbiological information on Río Celeste and its two tributaries, as well as a more detailed characterization of the particles that occur at the mixing point. Our results overturn the previous belief that the light scattering particles are formed by the aggregation of smaller particles coming from Río Buenavista, and rather point to chemical formation of hydroxyaluminosilicate colloids when Quebrada Agria is partially neutralized by Río Buenavista, which also contributes silica to the reaction. The process is mediated by the activities of different microorganisms in both streams. In Quebrada Agria, sulfur-oxidizing bacteria generate an acidic environment, which in turn cause dissolution and mobilization of aluminum and other metals. In Río Buenavista, the growth of diatoms transforms dissolved silicon into colloidal biogenic forms which may facilitate particle precipitation.

Conclusions
We show how the sky-blue color of Río Celeste arises from the tight interaction between chemical and biological processes, in what constitutes a textbook example of emergent behavior in environmental microbiology.
The current utilization of the patient-reported outcome measurement information system (PROMIS) in isolated or combined total knee arthroplasty populations
Authors: Gupta Puneet , Czerwonka Natalia , Desai Sohil S. , deMeireles Alirio J. , Trofa David P. , Neuwirth Alexander L. 
Published: January 2023

AbstractPatient reported outcome measures (PROMs) are essential for clinical research and patient-centric care because they allow us to capture patient perspectives on their health condition. In knee arthroplasty, PROMs are frequently used to assess the risks and benefits of new interventions, surgical approaches, and other management strategies. A few examples of PROMs used in total knee arthroplasty (TKA) include the Oxford Knee Score (OKS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and the Forgotten Joint Score (FJS) (collectively referred to as “legacy” PROMs). More recently, attention has been brought to another PROM called the Patient-Reported Outcomes Measurement Information System (PROMIS). PROMIS was developed by the National Institute of Health (NIH) and has over 300 domains assessing various aspects of patient health, including pain, physical function, and mental health. With the use of PROMIS increasing in TKA literature, there is a need to review the advancements being made in understanding and applying PROMIS for this population. Thus, the purpose of this study is to provide insight on the utilization, advantages, and disadvantages of PROMIS within the field of knee arthroplasty and to provide a comparison to legacy PROMs.
Impact of cetuximab plus cisplatin alone and cetuximab plus cisplatin and paclitaxel regimen on humanistic outcome in head and neck cancer
Authors: Khadela Avinash , Vyas Bhavin , Mansuri Mustakim , Sureja Dipen , Bodiwala Kunjan 
Published: January 2023

Abstract
Background
The prevalence of head and neck cancer (HNC) is increasing rapidly, and the prognosis is poor in the advance stage. For the patient suffering from advance stage HNC, the improvement in quality of life and decrease mortality remain as the mainstay of treatment. The aim was to assess the change in quality-adjusted life-years (QALYs) in recurrent or metastatic HNC patients receiving cetuximab plus cisplatin and cetuximab plus cisplatin-paclitaxel.

Methods
It was a single-centric prospective-observational study. Patients were divided into two cohorts based on the chemotherapy regimens they were prescribed. Patients in cohort 1 were prescribed with cetuximab and cisplatin and in cohort 2 were prescribed with cetuximab, cisplatin, and paclitaxel. The QALYs were the primary outcome of the study, and it was calculated using EQ-5D-5L instrument. Patients were followed until the completion of the therapy, i.e., six chemotherapy cycles. The statistical analysis was carried out using SPSS for descriptive and inferential analysis.

Results
Amongst 175 patients screened, 100 patients were enrolled which further distributed in cohorts 1 and 2 equally. The mean QALYs were 0.016 and 0.017 at the time of diagnosis, i.e., before initiation of chemotherapy for patients in cohorts 1 and 2, respectively. At every chemotherapy cycle, the QALYs were calculated. After the completion of six chemotherapy cycles, the mean QALYs were 0.029 and 0.032 for patients in cohorts 1 and 2, respectively.

Conclusion
The three-drug therapy consisting of cetuximab, cisplatin, and paclitaxel has shown significant improvement in patients’ QALYs compared to two-drug regimens of cetuximab and cisplatin. Thus, if the therapy consisted of three-drug regimen is used instead of two-drug regimen, it will have a positive impact on humanistic outcome in recurrent or metastatic HNC patients.
Prognostic value of echocardiographic indices in risk stratification of intermediate-risk pulmonary embolism
Authors: El-Morshedy Reham M. , El-kholy Maha M. , Hamad Dina A. , El-Sokkary Rofaida R. , Mohamed Marwan N. 
Published: January 2023

Abstract
Background
Regarding risk stratification of intermediate-risk pulmonary embolism, data are still not sufficient. Transthoracic echocardiography parameters may be useful in risk evaluation in those patients. Some novel echocardiographic indices mainly tricuspid regurgitation peak gradient (TRPG), pulmonary artery acceleration time, and tricuspid annulus plane systolic excursion (TAPSE) were evaluated showing that they may be used for risk stratification of normotensive cases with acute pulmonary embolism (APE).

Results
The studied cases were subdivided into two classes:
Class I with intermediate-low-risk pulmonary embolism included 32 patients (53.3%) and class II with intermediate high-risk pulmonary embolism involved 28 cases (46.7%). Dyspnea, tachypnea, troponin level, RVD, RVD/LVD, TR velocity, and TRPG/TAPSE were statistically higher in cases of class II than that of class I (p < 0.001). On the other hand, TAPSE and PA acceleration time were markedly lower in the case of class II than that of class I (p < 0.001). Ten cases (35.7%) of group II required thrombolytic agents with a significant difference (p<0.001).

Conclusions
RVD/LVD ratio, TAPSE, TRPG/TAPSE ratio, and PA acceleration time are echocardiographic parameters that might be helpful for risk stratification of cases with moderate-risk pulmonary embolism. The addition of elevated levels of cardiac troponins to imaging and clinical findings can improve PE-related risk identification.

Trial registration
NCT04020250. Registered on 16 July 2019.
Quinoline-Modified Phenanthroline Electron-Transporters as n-Type Exciplex Partners for Highly Efficient and Stable Deep-Red OLEDs
Authors: Saito Yu , Sasabe Hisahiro , Tsuneyama Hisaki , Abe Shoki , Matsuya Misaki , Kawano Tomoya , Kori Yuma , Hanayama Takanori , Kido Junji 
Published: January 2023

Abstract
Although stable deep-red organic light-emitting devices (OLEDs) exhibit potential applications as unique illumination light sources for plant growth and in health monitoring systems, their electron-to-photon conversion efficiency, represented by the external quantum efficiency (EQE), is significantly lower than that of the other primary colors. Thus, to overcome this limitation, n-type exciplex host partners based on quinoline-modified phenanthroline derivatives, X-BPhen, were designed and synthesized in this study. These X-BPhen derivatives formed exciplexes on combination with a p-type host material, NPD, behaving as host materials in deep-red phosphorescent OLEDs. The corresponding devices exhibited a maximum EQE of 17.6%, with CIE coordinates of (0.71, 0.29), and an LT80 of 410 h at a constant current density of 25 mA/cm2; this is among the best performances reported for stable deep-red OLEDs.
Alkyl-Chain Bridged Acrylonitrile-Appended Anthracene Chromophore toward Mechanically-Induced Bathochromic Shift
Authors: Tanikubo Hiroki , Matsuo Takumi , Hayashi Shotaro 
Published: January 2023

Abstract
Designing π-conjugated molecules for mechanochromism has attracted much attention. Here, we found an approach toward mechanofluorochromic dyes, which are composed of dimeric 9-(4-methoxyphenyl)acrylonitrile-appended anthracene units bridged by an alkyl chain. The molecule in an amorphous state showed a dramatic bathochromic shift (ΔλPL = 75 nm) after grinding while a crystalline state of the monomer motif showed a small hypsochromic shift (ΔλPL = 2–20 nm).
First isolation of a trh positive V. alginolyticus from Atlantic bluefin tuna (Thunnus thynnus) farmed in Turkey
Authors: Avsever Meriç Lutfi 
Published: January 2023

Popularity of sushi-sashimi (raw-almost raw fish service) is increasing around the globe, and Atlantic bluefin tuna is among the most frequently used fish in these dishes. In this study, trh (Thermostable direct hemolysin-related hemolysin gene) positive Vibrio alginolyticus was isolated from the internal organs of two tuna sent to the laboratory from a farm in Aegean region of Turkey in 2014. Isolation was done by conventional microbiological methods and Vitek 2 Compact fully automatic identification device was used for identification. Isolate confirmation and investigation of trh-tdh (Thermostable direct hemolysin) gene existence were carried out by a Polymerase Chain Reaction (PCR) method. Two V.alginolyticus isolates from two tuna were found to be trh positive and tdh negative. trh is one of the important genes associated with pathogenicity in the Vibrio genus, and raw consumption of tuna infected with trh positive V.alginolyticus can cause serious food poisoning. The aim of this study is to report first isolation of trh positive Vibrio alginolyticus from two bluefin tuna cultured in the Aegean sea, to draw attention to possible dangers in raw-almost raw fish consumption and supply information for further epidemiological studies. However, more samples are necesary for mentioning the prevalence of high virulence food pathogens in tuna. However, due to their economic value, multiple tuna samples are rarely sent to laboratories for diagnostic purposes.
Evaluation of immunostimulatory effects of a commercial herbal extract on avian influenza subtype H9N2 and Newcastle disease vaccination in chickens
Authors: Talazadeh Forough , Mayahi M , Fathi M 
Published: January 2023

Contrary to several vaccination programs to protect against bird flu and Newcastle disease (ND), these diseases remain a significant threat to the poultry industry. Improving the immune responses is important for many reasons such as vaccine failure, immunosuppressive diseases, and antibiotics misuse. Nowadays, research on materials likely to have immune-enhancing effects is increasing. Factors, substances, or compounds that can regulate different functions of the immune system can be used to enhance specific and even nonspecific responses to vaccines. The ability of herbal extracts to improve the immune system supports their use as immune stimulants. The present study aimed to examine the effects of barley malt extract in drinking water on humoral immunity of broiler chickens against ND and Avian Influenza (AI) disease subtype H9N2 vaccines. A total of 225 one-day-old broiler chicks (Ross strain) were divided into 5 groups of 3 subgroups and each subgroup had 15 chicks. Group A, B, and C chickens received 0.2%, 0.3%, and 0.5% of malt extract respectively in drinking water. Group D chickens did not get malt extract. Group E chickens did not receive malt extract and Newcastle and AI vaccines as the control group. All groups except group E were vaccinated with live Newcastle vaccine (B1 strain) intraocularly and AI-ND subtype H9N2 killed vaccine subcutaneously on the 7th day. Antibody titer against NDs and AI vaccines was considered by the Hemagglutination Inhibition test (HI test). Malt extract at 0.5% concentration, at all periods after vaccination, enhanced the systemic antibody response to ND vaccine in broiler chickens, but this extract had no significant effect on antibody response against the AI vaccine.Conclusion: Inoculation of ND vaccines with barley malt extract as an immune-boosting agent induces extensive immune responses involved in HI-NDV Ab titers.
The Relationship of Clinicopathological Parameters and Formula for Predicting Malondialdehyde Level in Feline Immunodeficiency Virus (FIV) - infected Cats
Authors: Sakundech Kanissarinn , Aengwanich Worapol 
Published: January 2023

The objective of this study was to investigate clinicopathological parameters, malondialdehyde and total antioxidant power for analyzing correlation and predicting malondialdehyde in plasma of feline immunodeficiency virus (FIV)-infected cats. Body condition score (BCS), mucous membrane color score (MMCS), vital signs, hematological parameters, malondialdehyde and ferric reducing antioxidant power (FRAP) of 20 FIV-infected cats were examined. The correlation and multiple regression model were then analyzed. The results revealed the following. The correlation between hemoglobin vs. packed cell volume (PCV), total red blood cell (TRBC) vs. PCV, TRBC vs. hemoglobin, mean corpuscular hemoglobin (MCH) vs. mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) vs. MCH, body temperature vs. eosinophil, total white blood cell (TWBC) vs. eosinophil, MMCS vs. platelet, eosinophil vs. malondialdehyde, PCV vs. FRAP, hemoglobin vs. FRAP, TRBC vs. FRAP and TRBC vs. FRAP were significantly positive correlated between pairs of these parameters (P<0.05), while body temperature vs. MCV, TRBC vs. MCV, heart rate vs. platelet, heart rate vs. platelet were significantly negatively correlated between pairs of parameters (P<0.05). A formula for predicting malondialdehyde was Heart Rate (beats/minute) = 166.341 + 5.438*Hemoglobin (g/dl) + 0.0009*Total White Blood Cell (cell/ml) - 1152.48*Malondialdehyde (µmol/ml) (MSE=132.2540; r2=0.85). These results indicated that there were correlations between some clinicopathological parameters, malondialdehyde and total antioxidant power and a formula for predicting malondialdehyde levels in plasma of FIV-infected cat was obtained.