bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasensitive Flexible Thermal Sensor Arrays based on High‐Thermopower Ionic Thermoelectric Hydrogel
Authors: Han Yang , Wei Haoxiang , Du Yanjun , Li Zhigang , Feng Shien‐Ping , Huang Baoling , Xu Dongyan 
Published: July 2023

AbstractIonic circuits using ions as charge carriers have demonstrated great potential for flexible and bioinspired electronics. The emerging ionic thermoelectric (iTE) materials can generate a potential difference by virtue of selective thermal diffusion of ions, which provide a new route for thermal sensing with the merits of high flexibility, low cost, and high thermopower. Here, ultrasensitive flexible thermal sensor arrays based on an iTE hydrogel consisting of polyquaternium‐10 (PQ‐10), a cellulose derivative, as the polymer matrix and sodium hydroxide (NaOH) as the ion source are reported. The developed PQ‐10/NaOH iTE hydrogel achieves a thermopower of 24.17 mV K−1, which is among the highest values reported for biopolymer‐based iTE materials. The high p‐type thermopower can be attributed to thermodiffusion of Na+ ions under a temperature gradient, while the movement of OH− ions is impeded by the strong electrostatic interaction with the positively charged quaternary amine groups of PQ‐10. Flexible thermal sensor arrays are developed through patterning the PQ‐10/NaOH iTE hydrogel on flexible printed circuit boards, which can perceive spatial thermal signals with high sensitivity. A smart glove integrated with multiple thermal sensor arrays is further demonstrated, which endows a prosthetic hand with thermal sensation for human–machine interaction.
Bioinspired PVDF Piezoelectric Generator for Harvesting Multi‐Frequency Sound Energy
Authors: Duan Bangyan , Wu Kefan , Chen Xiaoyang , Ni Jinyan , Ma Xin , Meng Weishuai , Lam Kwok‐ho , Yu Ping 
Published: July 2023

AbstractWith the rapid development of micro‐energy harvesting technology, noise has great potential as a new type of micro‐energy source by developing a high‐performance acoustic energy harvester (AEH). Nevertheless, the challenges of harvesting energy from noise are low acoustic energy density, multi‐frequency mixed sound, and unstable sound pressure. Piezoelectric‐based AEHs are proposed as a solution, but most reported devices need to work at a certain frequency and very high sound pressure, and exhibit the disadvantages of being bulky and heavy when using an extra sound‐pressure amplifier. Here, the eardrum and cochlea bioinspired polyvinylidene fluoride (PVDF) piezoelectric generator which is lightweight, compact, has a simple structure and is low‐cost, harvests multi‐frequency sound energy. Although using the commercial pure PVDF membrane, the prepared AEH still presents a high acoustoelectric conversion performance with an output power of 8.45 µW and an acoustic sensitivity of 1 V Pa−1 at 200 Hz and 100 dB without using any sound‐pressure amplifier through optimizing the structure–vibration–frequency relationship. More importantly, the bioinspired AEHs do not only exhibit the ability of acoustic energy harvesting function but also have the abilities of frequency recognition and acoustic sensing, which show great potential in the application of self‐powered acoustic sensors.
Dynamic Perovskite Homojunction Based Light‐Assisted, Direct Current Tribovoltaic Nanogenerators
Authors: Yin Xin , Xu Bingang , Kan Chi‐Wai , Yang Yujue 
Published: July 2023

AbstractTribovoltaic nanogenerators (TVNG) are an emerging energy technology featuring high direct current density and continuous power output. Recently, a new kind of perovskite/metal Schottky‐based TVNG has attracted increasing attention, which can co‐harvest mechanical and solar energy to dramatically improve the DC output performance. However, the instability of the perovskite‐metal interface and unnecessary carrier recombination loss limit its practicability. Here, a novel light‐assisted TVNG based on a dynamic N‐type perovskite/P‐type perovskite homojunction is developed. The homojunction design can ensure stable interface contact, and contributes to forming a strong built‐in electric field to promote efficient carrier separation/extraction and decrease interfacial charge recombination loss. In addition, the innovative design of the dual perovskite functional electrode maximizes its photovoltaic characteristics and further facilitates the excitation of more charges based on tribo‐photovoltaic coupling effects. Eventually, the output voltage and current of dynamic perovskite homojunction can boost up to ≈8.72 V and ≈30.84 µA under illumination, showing outstanding performance among the state‐of‐the‐art perovskite‐based TVNGs. These findings demonstrate the great potential of perovskite materials in generating DC power and present a feasible strategy to construct efficient, multifunctional TVNGs.
Clonal dynamics and copy number variants by single‐cell analysis in leukemic evolution of myeloproliferative neoplasms
Authors: Calabresi Laura , Carretta Chiara , Romagnoli Simone , Rotunno Giada , Parenti Sandra , Bertesi Matteo , Bartalucci Niccolò , Rontauroli Sebastiano , Chiereghin Chiara , Castellano Sara , Gentili Giulia , Maccari Chiara , Vanderwert Fiorenza , Mannelli Francesco , Della Porta Matteo , Manfredini Rossella , Vannucchi Alessandro Maria , Guglielmelli Paola 
Published: July 2023

AbstractTransformation from chronic (CP) to blast phase (BP) in myeloproliferative neoplasm (MPN) remains poorly characterized, and no specific mutation pattern has been highlighted. BP‐MPN represents an unmet need, due to its refractoriness to treatment and dismal outcome. Taking advantage of the granularity provided by single‐cell sequencing (SCS), we analyzed paired samples of CP and BP in 10 patients to map clonal trajectories and interrogate target copy number variants (CNVs). Already at diagnosis, MPN present as oligoclonal diseases with varying ratio of mutated and wild‐type cells, including cases where normal hematopoiesis was entirely surmised by mutated clones. BP originated from increasing clonal complexity, either on top or independent of a driver mutation, through acquisition of novel mutations as well as accumulation of clones harboring multiple mutations, that were detected at CP by SCS but were missed by bulk sequencing. There were progressive copy‐number imbalances from CP to BP, that configured distinct clonal profiles and identified recurrences in genes includingNF1,TET2, andBCOR, suggesting an additional level of complexity and contribution to leukemic transformation.EZH2emerged as the gene most frequently affected by single nucleotide and CNVs, that might result in EZH2/PRC2‐mediated transcriptional deregulation, as supported by combined scATAC‐seq and snRNA‐seq analysis of the leukemic clone in a representative case. Overall, findings provided insights into the pathogenesis of MPN‐BP, identified CNVs as a hitherto poorly characterized mechanism and point to EZH2 dysregulation as target. Serial assessment of clonal dynamics might potentially allow early detection of impending disease transformation, with therapeutic implications.
Changes in body weight and body composition during the menstrual cycle
Authors: Kanellakis Spyridon , Skoufas Efstathios , Simitsopoulou Eleftheria , Migdanis Athanasios , Migdanis Ioannis , Prelorentzou Tzortzia , Louka Aikaterini , Moschonis Georgios , Bountouvi Evangelia , Androutsos Odysseas 
Published: July 2023

AbstractObjectivesThe general perception is that menstrual cycle is a factor related to body weight and body composition fluctuations in women. The lack of a standardized methodology of the so far conducted studies has led to controversial results. The aim of the current study is to identify if there are any changes in body weight and body composition during the menstrual cycle.MethodsIn the current study measurements of body weight, circumferences, skinfolds and body composition with bioelectrical impedance analysis were conducted twice per week in 42 women during their menstrual cycle.ResultsBody weight was found to be statistically significantly higher during menstruation compared to the first week of the menstrual cycle by 0.450 kg, which could be attributed to a statistically significant increase of 0.474 kg observed in extracellular water. No other statistically significant changes were observed regarding body composition.ConclusionsAn increase of approximately 0.5 kg was observed during women's menstrual cycle, mostly due to extracellular fluid retention at menstruation days. These findings could be taken into account to interpret body weight and composition periodic fluctuations in women of reproductive age.
Adverse events associated with budesonide nasal irrigation reported to the US Food and Drug Administration: 2007 to 2022
Authors: Rathi Vinay K. , Sawicki Nicholas W. , Schlosser Rodney J. , Soler Zachary M. , Scangas George A. , Workman Alan D. , Gray Stacey T. 
Published: July 2023

KEYPOINTS
Between 2007 and 2022, the FDA received 119 US‐based reports mentioning budesonide nasal irrigation.
Most reports were submitted by patients and alerted FDA to off‐label usage of budesonide.
Notable adverse events reported to the FDA included headache, dyspnea, and blurred vision.
Levels of nasal nitric oxide and nitric oxide synthase expression in chronic rhinosinusitis with nasal polyposis
Authors: Wu Vincent , Cusimano Michael , Marsden Philip , Lee John M. 
Published: July 2023

Key points
CRSwNP patients had decreased nNO and increased SNOT‐22, endoscopy, and CT scores.
CRSwNP patients exhibited decreased nNO despite elevated iNOS and eNOS mRNA expression.
The mechanism behind lowered nNO in CRSwNP may not be related to NOS expression.
Interpenetrating polymer network based hydrogel: A smart approach for corroborating wound healing of various capacity
Authors: Sarangi Manoj Kumar , Padhi Sasmita , Patel L. D. , Rath Goutam , Nanda Sitansu Sekhar , Yi Dong Kee 
Published: July 2023

AbstractHemorrhage of high intensity usually leads to severe mortality accidents, disaster, and warfare. The concomitant wound thereby induces immense psychological as well as physical trauma to the patients. Hence, a faster hemostasis with smart wound healing approaches are highly essential to deal such critical/life threatening situations. The traditional approaches such as implementation of gauze and bandages are found to be having limited scope for controlling hemorrhage, because of non‐biodegradability, high susceptibility towards infection, unsuitability for irregular wound and ineffective towards wound healing. By virtue of the merits revealed by remodeling interpenetrating polymer network (IPN) based hydrogels (biocompatibility, high porosity, tunability, biomimetic and better retention, and proliferative wound healing tendency), have drawn a rigorous attention to out play their ancestors. This review includes the involvement of numerous synthetic routes, types and physicochemical properties of IPN based hydrogels loaded with diverse therapeutic agents towards wound repair/healing. Moreover, some of the recent patents have been portrayed in the manuscript, dignifying the potentiality of fascinating IPN hydrogels towards effective wound healing. More research is required to engineer multifaceted IPN hydrogels to attain huge potential against the challenges and future perspectives in wound healing.
Viscoelastic properties of thermosensitive gelatin/tragacanth hydrogel as novel ink suitable for additive manufacturing: Effect of various additives on system's viscoelastic characteristics and printability
Authors: Zehtab Minooei H. , Kaffashi B. 
Published: July 2023

AbstractIn this study, a novel hydrogel ink made from gelatin and tragacanth gum was prepared. Two additives and a crosslinking agent were added to improve the viscoelastic properties of the material during gelation and its printability. Alginic acid was introduced as a crosslinking agent along with additives such as rice starch and halloysite nanotubes (HNT). Two rheological measurement modes, rotational and oscillatory, were utilized to measure the steady state viscosity and complex moduli, respectively. Auxiliary measurements such as Fourier‐transform spectroscopy infrared and gel permeation chromatography were implemented to determine the bonds formed and the molecular weight of gelatin and tragacanth gum, respectively. We have demonstrated how these additives can affect fluid uptake by examining them in water at ambient temperature and also in 1× PBS at both ambient and normal body temperatures. The printability was analyzed by the grid pattern dispensed by interconnected filaments. It was observed that the sample containing HNT and rice starch show the best properties. The hydrogel nanocomposite, unlike the pure gelatin films, retains water and buffer solution for 72 h with minimum changes. Moreover, the printability criterion (Pr) was improved from 0.3 for pure gelatin to about 1 for the sample containing alginate, HNT, and rice starch.
Enhancement effect of polyurea coating on the impact resistance of aluminum foam
Authors: Guo Hui , Song Fuchen , Sun Minqian , Chen Yu 
Published: July 2023

AbstractA polyurea coating was prepared to enhance the impact protection performance of aluminum foam, and its mechanical properties were analyzed. Polyurea‐coated aluminum foam composite specimens were prepared by coating the polyurea on the surface of aluminum foam. The mechanical properties of composite specimens under quasi‐static and dynamic loading were tested, and the stress–strain relationship at different strain rates was analyzed. The deformation process and failure mode of typical specimens under different loading conditions were discussed. The influence of polyurea coating on the energy absorption characteristics of aluminum foam was explained. The results show that when the polyurea is coated on the end surface of aluminum foam specimen, the sawtooth oscillation in the yield plateau stage of the stress–strain curve is weakened. The existence of polyurea coating makes the stress transfer of cell wall of aluminum foam uniform, and can effectively prevent the damage caused by the splash of aluminum foam fragments under high‐speed impact load. Coating polyurea on the opposite to load‐receiving surface of aluminum foam specimen can effectively improve the yield stress of composite specimen under dynamic load, and make the specimen still maintain good integrity after failure. When the polyurea is coated on the end surface of aluminum foam specimen, the final energy absorption per unit volume and the ideal energy absorption efficiency peak of the specimen are improved.
Preparation of high positioning accuracy lattice patterns with polymeric microfibers derived from near‐field electrospinning
Authors: Zhu Long , Liang Junsheng , Li Xiaojian , Su Shijie , Wang Huaan , Xiao Jianping , Sun Lujing , Wang Dazhi 
Published: July 2023

AbstractElectrospinning is a straightforward and versatile technology that has been broadly applied to the preparation of microfibers. However, the fabrication of complicated patterns with high positioning accuracy is still a challenge. The enhancement of the positioning accuracy is restricted by the bending instability of the jet and the motion stage. Here, an effective method to improve the positioning accuracy of ordered fibers by optimizing printing parameter and printing order is proposed. Highly oriented and uniformly aligned microfiber arrays composed of polyethylene oxide (PEO) fibers with a diameter of 2.8 ± 0.13 μm are deposited by adjusting the process parameters. Moreover, the accumulative return error of the printed pattern was reduced by 30.54 μm in X‐axis and 55.59 μm in Y‐axis using an optimized printing order. The lattice patterns with a high positioning accuracy of 0.98 ± 0.06 μm were obtained, which is nearly two orders of magnitude higher than that of the structure with unoptimized printing order. Results indicate that the method can significantly improve the positioning accuracy of the lattice patterns of polymeric microfibers, which has a promising prospect in the field of high‐precision micro manufacturing.
From probiotics to postbiotics: Concepts and applications
Authors: Liu Chunchen , Ma Ning , Feng Yue , Zhou Min , Li Huahui , Zhang Xiujun , Ma Xi 
Published: July 2023

AbstractIn recent years, the important role of gut microbiota in promoting animal health and regulating immune function in livestock and poultry has been widely reported. The issue of animal health problems causes significant economic losses each year. Probiotics and postbiotics have been widely developed as additives due to their beneficial effects in balancing host gut microbiota, enhancing intestinal epithelial barrier, regulating immunity, and whole‐body metabolism. Probiotics and postbiotics are composed of complex ingredients, with different components and compositions having different effects, requiring classification for discussing their mechanisms of action. Probiotics and postbiotics have considerable prospects in preventing various diseases in the livestock industry and animal feed and medical applications. This review highlights the application value of probiotics and postbiotics as potential probiotic products, emphasizing their concept, mechanism of action, and application, to improve the productivity of livestock and poultry.
Antibiotic prophylaxis in flexible ureterorenoscopy with negative urine culture
Authors: Méndez‐Guerrero Daniela María , Buitrago‐Carrascal Christian , Puentes‐Bernal Andrés Felipe , Cruz‐Arévalo Dilma Alexandra , Camacho ‐Nieto Diego , Calderón Marcelo Andrés , Álvarez‐Restrepo Juan Camilo , Brijaldo‐Carvajal Mayra Alejandra , Perdomo‐Bernal Natalia , Moreno‐Matson María Carolina , Ibañez‐Pinilla Milciades , Daza‐Vergara José 
Published: July 2023

AbstractObjectiveTo improve susceptibility profiles of nosocomial bacteria, identifying the difference between infectious complications in patients undergoing endoscopic flexible ureterolithotomy (fURS) with negative urine culture (UC) that received extended antibiotic prophylaxis (EP) compared with standard antibiotic prophylaxis (SP).MethodologyThis is a retrospective, observational, analytical cohort study, comparing infectious complications between patients undergoing fURS with negative UC who received EP versus SP. We include patients with susccessfull fURS, <20‐mm stones and complete information.ResultsOverall, 10.3% of patients had complications, 7.2% of patients had postoperative urinary infection, 1.8% had upper urinary tract infection (UTI) and 1.4% had urinary sepsis. Lower UTI were significantly more likely in the extended prophylaxis group with 6.8% versus 2.7% (RR = 2.8; 95% CI: 1.10–7.37, p = 0.030). The risk of upper UTI and sepsis did not show significant differences. A total of 69% patients with postoperative infection had isolated multidrug‐resistant bacteria (MDRB) in the UC, with a higher risk in patients with extended prophylaxis (RR = 3.1; 95% CI: 1.33–7.59, p = 0.009).ConclusionsPatients with negative UC who underwent fURS using extended prophylaxis have two times higher risk of low UTI than patients with standard prophylaxis, without differences in the incidence of upper UTI or urinary sepsis. The risk of MDRB isolation in the postoperative UC is higher in the extended prophylaxis group, therefore we recommend the standard 60‐min preoperative prophylaxis.
Investigating (sequential) unit asking: An unsuccessful quest for scope sensitivity in willingness to donate judgments
Authors: Maier Maximilian , Caviola Lucius , Schubert Stefan , Harris Adam J. L. 
Published: July 2023

AbstractPeople exhibit scope insensitivity: Their expressed valuation of a problem is not proportionate with its scope or size. To address scope insensitivity in charitable giving, Hsee et al. (2013) developed the (Classical) Unit Asking technique, where people are first asked how much they are willing to donate to support a single individual, followed by how much they are willing to donate to support a group of individuals. In this paper, we explored the mechanisms, extensions, and limitations of the technique. In particular, we investigated an extension of the technique, which we call Sequential Unit Asking (SUA). SUA asks people a series of willingness‐to‐donate questions, in which the number of individuals to be helped increases in a stepwise manner until it reaches the total group size. Across four studies investigating donation judgments (total
), we did not find evidence that willingness to donate (WTD) judgments to the total group increased with larger groups. Instead, our results suggest that Unit Asking (sequential or classical) increases donation amounts only through a single one‐off boost. Further, we find evidence in three out of four studies that the SUA extension increases WTD judgments over Classical Unit Asking. In a fifth study (
) using a contingent valuation design (instead of donation judgments), we find scope sensitivity using all asking techniques. We conclude that, while it is difficult to create scope sensitivity in WTD judgments, SUA should be considered a promising approach to increase charitable donations.
Primary cardiac sarcomas: A clinicopathologic study in a single institution with 25 years of experience with an emphasis on MDM2 expression and adjuvant therapy for prognosis
Authors: Cho Haeyon , Song In‐Hye , Jo Uiree , Jeong Ji‐Seon , Koo Hyun Jung , Yang Dong Hyun , Jung Sung‐Ho , Song Joon Seon , Cho Kyung‐Ja 
Published: July 2023

AbstractBackgroundPrimary cardiac sarcomas are rare and their clinicopathologic features are heterogeneous. Among them, particularly intimal sarcoma is a diagnostic challenge due to nonspecific histologic features. Recently, MDM2 amplification reported to be a characteristic genetic event in the intimal sarcoma. In this study, we aimed to identify the types and incidence of primary cardiac sarcomas that occurred over 25 years in tertiary medical institutions, and to find clinicopatholgical significance through reclassification of diagnoses using additional immunohistochemistry (IHC).MethodsWe reviewed the primary cardiac sarcoma cases between January 1993 and June 2018 at Asan Medical Center, South Korea, with their clinicopathologic findings, and reclassified the subtypes, especially using IHC for MDM2 and then, analyzed the significance of prognosis.ResultsForty‐eight (6.8%) cases of a primary cardiac sarcoma were retrieved. The tumors most frequently involved the right atrium (n = 25, 52.1%), and the most frequent tumor subtype was angiosarcoma (n = 23, 47.9%). Seven cases (53.8%) were newly reclassified as an intimal sarcoma by IHC for MDM2. Twenty‐nine (60.4%) patients died of disease (mean, 19.8 months). Four patients underwent a heart transplantation and had a median survival of 26.8 months. This transplantation group tended to show good clinical outcomes in the earlier stages, but this was not statistically significant (p = 0.318). MDM2 positive intimal sarcoma showed the better overall survival (p = 0.003) than undifferentiated pleomorphic sarcoma. Adjuvant treatment is beneficial for patient survival (p < 0.001), particularly in angiosarcoma (p < 0.001), but not in intimal sarcoma (p = 0.154).ConclusionOur study supports the use of adjuvant treatment in primary cardiac sarcoma, as it was associated with a significantly better overall survival rate. Further consideration of tumor histology may be important in determining the optimal use of adjuvant treatment for different types of sarcomas. Therefore, accurate diagnosis by MDM2 test is important condsidering patient's prognosis and treatment.