bluuebunny/crossref_metadata_2025_split huggingface dataset:
Timed receptor tyrosine kinase signaling couples the central and a peripheral circadian clock inDrosophila
Authors: Cavieres-Lepe Javier , Amini Emad , Nässel Dick R. , Stanewsky Ralf , Wegener Christian , Ewer John 
Published: May 2023

AbstractCircadian clocks impose daily periodicities to behavior, physiology, and metabolism. This control is mediated by a central clock and by peripheral clocks, which are synchronized to provide the organism with a unified time through mechanisms that are not fully understood. Here, we characterized inDrosophilathe cellular and molecular mechanisms involved in coupling the central clock and the peripheral clock located in the prothoracic gland (PG), which together control the circadian rhythm of emergence of adult flies. The time signal from central clock neurons is transmitted via small neuropeptide F (sNPF) to neurons that produce the neuropeptide Prothoracicotropic Hormone (PTTH), which is then translated into circadian oscillations of Ca2+concentration and daily changes in PTTH levels. Rhythmic PTTH signaling is required at the end of metamorphosis, and transmits time information to the PG by imposing a daily rhythm to the expression of the PTTH receptor tyrosine kinase (RTK), TORSO, and of ERK phosphorylation, a key component of PTTH transduction. In addition to PTTH, we demonstrate that signaling mediated by other RTKs contribute to the rhythmicity of emergence. Interestingly, the ligand to one of these receptors (Pvf2), plays an autocrine role in the PG, which may explain why both central brain and PG clocks are required for the circadian gating of emergence. Our findings show that the coupling between the central and the PG clock is unexpectedly complex and involves several RTKs that act in concert, and could serve as a paradigm to understand how circadian clocks are coordinated.Significance statementCircadian clocks impose daily periodicities to behavior, physiology, and metabolism, and are synchronized to provide the organism with a unified time through mechanisms that are poorly understood. In holometabolous insects, the circadian control of adult emergence depends on the coupling between the central clock and a peripheral clock located in the prothoracic gland (PG). Here we identify the cellular and molecular mechanism that transmits time information from the central clock to the PG clock. This process is unexpectedly complex and involves a number of receptor tyrosine kinases (RTKs). Such a mechanism may add robustness to the coupling between the 2 clocks and serve as a paradigm for understanding how circadian clocks are coordinated.
Serotonin neurons in mating female mice are activated by male ejaculation
Authors: Troconis Eileen L. , Seo Changwoo , Guru Akash , Warden Melissa R. 
Published: May 2023

SUMMARYSexual stimulation triggers changes in female physiology and behavior, including sexual satiety and preparing the uterus for pregnancy. Serotonin is an important regulator of reproductive physiology and sexual receptivity, but the relationship between sexual stimulation and serotonin neural activity in females is poorly understood. Here, we investigated dorsal raphe serotonin neural activity in females during sexual behavior. We found that serotonin neural activity in mating females peaked specifically upon male ejaculation, and remained elevated above baseline until disengagement. Artificial intravaginal mechanical stimulation was sufficient to elicit increased 5-HT neural activity but the delivery of ejaculatory fluids was not. Distal penis erectile enlargement (“penile cupping”) at ejaculation and forceful expulsion of ejaculatory fluid each provided sufficient mechanical stimulation to elicit serotonin neuron activation. Our study identifies a female ejaculation-specific signal in a major neuromodulatory system and shows that intravaginal mechanosensory stimulation is necessary and sufficient to drive this signal.
Oncometabolite lactate enhances breast cancer progression by orchestrating histone lactylation-dependent c-Myc expression
Authors: Pandkar Madhura R. , Sinha Sommya , Samaiya Atul , Shukla Sanjeev 
Published: May 2023

AbstractOwing to the enhanced glycolytic rate, cancer cells generate lactate copiously, which in turn, promotes lactylation of histone. Even though histone lactylation has been explored to alter the expression of few genes, the role of this epigenetic modification in regulating the expression of oncogenes is largely unchartered. In this study, using breast cancer cell lines their mutants (which exhibit lactate-deficient metabolome), we have identified that intracellular lactate promotes histone lactylation-dependent c-Myc upregulation. Furthermore, we report that the c-Myc upregulates serine/arginine splicing factor 10 (SRSF10) to drive alternative splicing in breast cancer cells. Our findings provide novel mechanistic insights into the role assayed by aerobic glycolysis in orchestrating alternative splicing that collectively drive breast tumorigenesis. Moreover, we also envisage that chemotherapeutic interventions attenuating glycolytic rate can restrict breast cancer progression by impeding the c-Myc-SRSF10 axis.
Standard of workmanship, crime rate and condition of lift systems influence collective action in low-cost housing
Authors: Wang Hong Kok , Au-Yong Cheong Peng , Ling Gabriel Hoh Teck , Law Kian Aun 
Published: May 2023

Purpose
Under Malaysian Law, the maintenance and management of common property have traditionally been viewed as insoluble challenges in the self-organisational efforts for high-rise low-cost housing developments. As the population increases, more shared resources become heavily exploited with few willing to contribute towards the sustainability of resources. Many researchers argued a better way would be to convert these shared resources into a private or state-managed entity. Hence, with that assumption, this paper aims to examine how better physical characteristics can result in greater collective action.

Design/methodology/approach
This research paper adopted a quantitative method approach to determine how the standard of physical characteristics influenced the quality of collective action in high-rise low-cost housing. The method included a questionnaire survey of 519 parcel holders chosen via stratified purposeful random sampling from four high-rise low-cost housing areas.

Findings
The paper found a positive correlation between the quality of physical characteristics and the collective action gained. The findings highlighted that the standard of workmanship of high-rise low-cost units (including the common properties), the crime rate in the neighbourhood and the condition of lift systems – when improved – were significant positive predictors of collective action.

Practical implications
Housing developers should pay attention to the quality of both low-cost units and related common properties, as this endeavour will assist greatly in future collective action management.

Originality/value
The study was justified in terms of its originality as few research studies adopted the social-ecological system framework that focused on the correlation between the quality of physical characteristics and the collective action of parcel holders.
The influence of the propensity of small-firm managers to enroll in training programs on subsequent training outcome
Authors: Wickstrøm Kent Adsbøll , Bager Torben Eli 
Published: May 2023

PurposeThis study examines the relationship between small-firm managers' propensity to participate in a growth-oriented training program and their subsequent program outcome in terms of strategic reorientation. From a policy perspective, this relates to the important question of what benefit would come from recruiting managers who are normally not easily recruitable for training programs.Design/methodology/approachA control group design including pre- and post-training surveys is used to assess the effects of a large-scale management training program. Accounting for selection bias, the difference-in-difference method, together with propensity score matching, was applied to assess average program effects. The matching-smoothing method was used to assess heterogeneity in program effects associated with participation propensity.FindingsOverall, program participation associated positively with change in strategic orientations. This effect was especially pronounced for managers with either low or medium to high inclinations for program enrollment, while diminishing in the modest to medium range.Practical implicationsThe findings have important practical implications for selection of target groups and recruitment strategies in relation to small-firm management training programs. From the results, recruitment strategies may effectively include managers with either high or low participation propensities, rather than aiming to “fill up” with managers with moderately low participation propensity.Originality/valueSeveral extant studies have examined average treatment effects from small-firm training programs. Yet there has been a lack of examination of the extent to which participation propensity modifies the effect of training on outcomes. This study brings new knowledge of the direction and magnitude of such heterogeneous training effects.
A lane-based advanced forwarding protocol for internet of vehicles
Authors: Seth Ishita , Guleria Kalpna , Panda Surya Narayan 
Published: May 2023

Purpose
The internet of vehicles (IoV) communication has recently become a popular research topic in the automotive industry. The growth in the automotive sector has resulted in significant standards and guidelines that have engaged various researchers and companies. In IoV, routing protocols play a significant role in enhancing communication safety for the transportation system. The high mobility of nodes in IoV and inconsistent network coverage in different areas make routing challenging. This paper aims to provide a lane-based advanced forwarding protocol for internet of vehicles (LAFP-IoV) for efficient data distribution in IoV. The proposed protocol’s main feature is that it can identify the destination zone by using position coordinates and broadcasting the packets toward the direction of destination. The novel suppression technique is used in the broadcast method to reduce the network routing overhead.

Design/methodology/approach
The proposed protocol considers the interferences between different road segments, and a novel lane-based forwarding model is presented. The greedy forwarding notion, the broadcasting mechanism, and the suppression approach are used in this protocol to reduce the overhead generated by standard beacon forwarding procedures. The SUMO tool and NS-2 simulator are used for the vehicle's movement pattern and to simulate LAFP-IoV.

Findings
The simulation results show that the proposed LAFP-IoV protocol performs better than its peer protocols. It uses a greedy method for forwarding data packets and a carry-and-forward strategy to recover from the local maximum stage. This protocol's low latency and good PDR make it ideal for congested networks.

Originality/value
The proposed paper provides a unique lane-based forwarding for IoV. The proposed work achieves a higher delivery ratio than its peer protocols. The proposed protocol considers the lanes while forwarding the data packets applicable to the highly dense scenarios.
A hybrid framework for fleet management with quality concerns: a case for the food industry
Authors: Fares Naila , Lloret Jaime , Kumar Vikas , Frederico Guilherme F. , Kamach Oulaid 
Published: May 2023

PurposeThe purpose of the study is to propose a framework for fleet management and make suitable distribution solution choices in the food industry.Design/methodology/approachThis study reviews the literature to examine food distribution criteria. These criteria are used in the analytic hierarchy process (AHP) assessment and combined with discrete events simulation in a structured framework, which is validated through an empirical study.FindingsThe empirical case results demonstrate that both the AHP and discrete events simulation converge toward the same solution in most cases.Originality/valueThis study contributes to the literature on distribution management and develops a framework that can both guide future research and aid logistics practitioners in analysing distribution decision-making systems in dynamic environments.
The impact of omnichannel integrated marketing communications (IMC) on product and retail service satisfaction
Authors: Butkouskaya Vera , Oyner Olga , Kazakov Sergey 
Published: May 2023

PurposeThis study reviewed three customer-perceived components of integrated marketing communications (IMCs): consistency, interactivity and connectivity, as predictors of positive customer evaluation (product and retail service satisfaction).Design/methodology/approachThe customer data from 260 surveys were analysed using structural equation modelling (SEM). The data were collected from the emerging economy in the Moscow region (Russia).FindingsThe results reported that IMC consistency positively impacts product and service satisfaction. However, the effect of IMC interactivity was only significant in the case of service satisfaction. Meanwhile, IMC connectivity positively influenced only product satisfaction.Research limitations/implicationsThe study contributes to the marketing communications theory by defining three components of omnichannel IMC. It also adds to the customer behaviour theory by confirming the diverse nature of product and service evaluation. This study focuses on the retail industry.Practical implicationsThis research suggests that three components of IMC should be applied together towards enhancing the customer's positive post-purchase evaluation. Meanwhile, consistency enhances product and service satisfaction, interactive impacts satisfaction with the organization and connectivity with the retail service.Originality/valueThe shift toward omnichannel marketing requires a broader perspective on communication integration. This research reports a novelty result of estimating the separate effect of each component of omnichannel IMC (consistency, interactivity and connectivity) on product and service satisfaction.
Mapping of Journal of Hospitality and Tourism Insights themes: a retrospective overview
Authors: Moradi Erfan 
Published: May 2023

PurposeRecognising the literature of a field is vital for advancement in that field. Yet, there has not been a systematic analysis of recent publications published in the Journal of Hospitality and Tourism Insights (JHTI). Therefore, this research aims to do a bibliometric analysis of articles published in JHTI during the previous five years.Design/methodology/approachThis study used bibliometric techniques and indicators to analyse JHTI publications from 2018 to 2022. The data utilised in the study were obtained from Scopus and subsequently subjected to analysis through the Bibliometrix software.FindingsThe findings show good collaboration between the production components (country, institution and author) in JHTI. The co-occurrence analysis of keywords comprises five clusters; the co-citation analysis comprises six; and a group of articles connected with psychological aspects and areas such as motivation, attitude, customer engagement, place attachment and behavioural intention was the most remarkable cluster. Sharing economy, destination marketing, destination image and some, to an extent, social media and revenue management are just a few of the niche themes that have the potential to come up.Research limitations/implicationsThis study will be helpful as a roadmap for researchers in different fields who are interested in such studies, as well as for editorial board members and those who work in JHTI.Practical implicationsScholars and practitioners may benefit the most from this research by obtaining insight into the development of JHTI's research and the areas of the hospitality and tourism industries that need more study.Originality/valueThe current study is both necessary and valuable because it is the first to provide insight into the effectiveness and intellectual framework of the hospitality and tourism literature selected by the JHTI.
Preparing culturally competent teachers through clinical practices abroad
Authors: Mulvaney Tracy , Lubniewski Kathryn , Morales Wendy 
Published: May 2023

PurposeClinical practice provides teacher candidates with opportunities to link teaching and learning theory to practice in a supported environment with strong mentorship through their initial phases of teaching. Teacher candidates wait in anticipation for the opportunity to get into classrooms to work alongside veteran teachers to promote student learning and achievement. This article presents one educator preparation program’s (EPP’s) innovative program that spans the boundaries of the USA to provide teacher candidates with a two-week intensive full-time clinical placement in schools located in the Cotswold Region of England.Design/methodology/approachHighlighted in this piece is the program’s partnership history, design, structure, connection to the nine essentials, assessment of program goals, and a synthesis of the literature on global education and its value in educator preparation.FindingsHighlighted in this piece is the program’s partnership history, design, structure, connection to the nine essentials, assessment of program goals and a synthesis of the literature on global education and its value in educator preparation.Originality/valueThis article highlights one university’s innovation that places teacher candidates in the classroom for a two-week full-time immersive clinical experience in various schools in England. As early as their sophomore year, teacher candidates can participate in this study abroad program and do so while developing their own cultural competence and global citizenship.
Recent progress in food processing applications of air impingement technology: A review
Authors: Altay Özgül , Selçuk Esin , Abacı Ömer , Erdem Funda , Dirim S. Nur , Şentürk Utku , Kaymak‐Ertekin Figen 
Published: May 2023

AbstractAir impingement method has been widely used in a variety of industrial applications, such as textile and paper drying, turbine cooling, and glass quenching, because it is an efficient technology with high heat and mass transfer rates. This technology has received increasing interest in the field of food processing over the last two decades, such as drying, baking, blanching, freezing, and thawing. In a food processing equipment using air impingement, jets of high‐velocity air (with speeds of 10–50 m/s) are directed at a food product. The performance of the system is influenced by several critical elements, including jet velocity, nozzle array diameter and layout, jet distance, and boundary layer characteristics. The use of computational fluid dynamics, an emerging tool, has been shown to be valuable in the analysis of fluid flow and heat and mass transfer in jet impingement systems. The physical properties of impinging jets, such as turbulent mixing in the free jet zone, stagnation, boundary layer formation, recirculation, and their interactions with food products in terms of heat and mass transfer, have been discussed in this article. The benefits and disadvantages of air jet impingement technology in different food processing applications together with potential trends for improving impingement technology performance were identified and discussed. This review not only contributes to a better understanding of the research status of impingement technology on food processing but also triggers new research opportunities in this field in order to provide more healthy and nutritious food in a more sustainable way to the world's growing population.
Chemotherapy outcomes in EGFR‐TKI resistant patients with common and uncommon EGFR mutation: An exploratory retrospective cohort study
Authors: Lin Chien‐Yu , Hu Chia‐Hao , Hsu Chia‐Fu , Tsai Jeng‐Shiuan , Chen Chian‐Wei , Lin Chia‐Yin , Chang Chao‐Chun , Yen Yi‐Ting , Tseng Yau‐Lin , Su Po‐Lan , Lin Chien‐Chung 
Published: May 2023

AbstractBackgroundSome prospective studies have shown that second‐generation tyrosine kinase inhibitors (TKIs) provide better control in patients with non‐small cell lung cancer (NSCLC) with uncommon epidermal growth factor receptor (EGFR) mutations. However, studies comparing second‐line chemotherapy efficacy between NSCLC patients with common and uncommon EGFR mutations remain rare. This retrospective study compared treatment outcomes in these patients.MethodsPatients with EGFR‐mutated advanced‐stage NSCLC who received first‐line EGFR‐TKIs in a tertiary referral center were retrospectively reviewed between January 2010 and August 2022. Patients with a negative T790M test at disease progression who received second‐line chemotherapy were enrolled. We compared progression‐free (PFS) and overall (OS) survival between advanced NSCLC patients with common and uncommon EGFR mutations using Kaplan–Meier and log‐rank tests.ResultsIn total, 209 (54.8%) patients had a negative T790M mutation test and received second‐line chemotherapy, of which 192 (91.8%) had a common EGFR mutation (exon 19 deletion or exon 21 L858R substitution), and 17 (8.2%) had an uncommon EGFR mutation. Patients with common EGFR mutations had significantly longer PFS than those with uncommon EGFR mutations (4.57 vs. 2.57 months, p = 0.031). A Cox proportional hazard regression analysis controlling for potential confounding factors indicated that an uncommon EGFR mutation was an independent prognostic factor for PFS.ConclusionThis study suggests that patients with uncommon EGFR mutations have poorer chemotherapy responses and shorter survival than those with common EGFR mutations. The development of new treatment strategies for these patients remains an unmet need.
Combination of azacitidine, venetoclax and ruxolitinib in blast phase myeloproliferative neoplasms
Authors: Systchenko Thomas , Chomel Jean‐Claude , Gallego‐Hernanz Pilar , Moya Niels , Desmier Déborah , Maillard Natacha , Bobin Arthur , Vonfeld Mathilde , Gardeney Hélène , Cayssials E Emilie , Torregrosa José 
Published: May 2023

SummaryMyeloproliferative neoplasms in blastic phase (MPN‐BP) have a dreadful prognosis. We report the characteristics and outcomes of five MPN‐BP patients treated with a never‐before‐described combination of azacytidine and venetoclax (to control BP transformation), added to ruxolitinib (needed to control constitutional symptoms). Median age was 76 years (range 72–84), and worst performance status was 2. The overall response rate was 80%, and the complete remission rate was 40%. With median follow‐up of 10.0 months (range 4.2–13.4), median overall survival was 13.4 months (95% CI 4.2–13.4). We did not detect any unexpected treatment‐related toxicity, and quality of life was improved.