bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemolysis, icterus and lipemia interfere with the determination of Thiobarbituric Acid Reactive Substances (TBARS) and Total Antioxidant Status (TAS) in canine serum.
Authors: Perez-Montero Blanca , Fermin-Rodriguez Maria Luisa , Miro Guadalupe , de Juan Lucia , Cruz-Lopez Fatima 
Published: May 2023

Abstract
Background
Oxidative stress has been proved to participate in a plethora of human and canine diseases. Among oxidative stress biomarkers, Thiobarbituric Acid Reactive Substances (TBARS) and Total Antioxidant Status (TAS) are two of the most widely used. Pre-analytical factors are highly relevant to obtain accurate results in these assays. Hemolysis, icterus and lipemia (HIL) are among the most frequent sources of pre-analytical errors in the laboratory, but limited information is available on the considerations for canine specimens. Hence, the objective of this study was to assess the potential interferences due to HIL on the determination of TBARS and TAS in canine serum.
Methods
Dilutions of canine pooled serum samples were prepared with increasing concentrations of hemolysate, bilirubin and a synthetic lipid emulsion. TBARS and TAS were determined, and biases from the control value due to the interferents were calculated.
Results
Hemolysis, icterus and lipemia induced significant interferences on TBARS and TAS, to a variable extent depending on the biomarker and interferent. TBARS seemed the most vulnerable method to interferences in this study. Slight hemolysis, moderate icterus and slight lipemia induced significant deviations of TBARS value, exceeding the acceptable interference threshold. TAS assay was also affected by HIL, but to a lesser extent compared to TBARS. Significant biases from TAS control value were observed when icterus was moderate, and hemolysis and lipemia were marked.
Conclusions
TBARS and TAS assays are widely used for oxidative stress evaluation. However, the literature on the interference of HIL on these biomarkers in canine serum is scarce. In light of our results, we conclude that hemolyzed, icteric and lipemic specimens are not suitable for TBARS and TAS determination in canine serum. Our findings seem of considerable practical utility, as a simple visual inspection would be sufficient for discarding these specimens.
Perinatal mental health professionals’ experiences and perceptions of working with mothers who are suicidal during the perinatal period: A reflexive thematic analysis study
Authors: Reid Holly E. , Edge Dawn , Pratt Daniel , Wittkowski Anja 
Published: May 2023

Abstract
Background Suicide is the leading cause of death in mothers postpartum and one of the most common causes of death during pregnancy. As mental health professionals, who work with mothers experiencing suicidal thoughts and behaviour during pregnancy and postpartum, can offer insights into the characteristics of mothers most likely to experience suicidal ideation and behaviour, how they can support these mothers and improve current practices, we aimed to explore mental health professionals’ experiences and perceptions.Method As part of this qualitative study, semi-structured interviews were conducted face-to-face or via telephone with mental health professionals working in perinatal mental health inpatient or community services across England. Data were analysed using reflexive thematic analysis.Results Fifteen professionals took part in this study and two main themes were developed from their interview data. The first theme, identifying the problem(s), overarched three subthemes: 1.1) the mother’s context, 1.2) what the baby represents and what this means for the mother, and 1.3) types of suicidal ideation and attempts. These subthemes described factors that professionals assessed or deemed contributory in relation to suicidal ideation/behaviour when a mother was under their care. The second main theme, reducing suicidal ideation and behaviour, outlined how professionals understood and tried to treat the suicidal ideation/behaviour. This theme encapsulated two subthemes: 2.1) how to talk about suicide and 2.2) changing how a mother views her baby and herself.Conclusion Professionals highlighted many factors that should be considered when responding to a mother’s risk of suicide during the perinatal period, such as the support around her, whether the pregnancy was planned and what the baby represented for the mother. Professionals’ narratives highlighted the importance of adopting a tailored approach to discussing suicidal thoughts, plans and behaviours with mothers to encourage disclosure. Our findings also identified psychological factors that professionals perceived as being linked to suicidal outcomes for mothers, such as self-efficacy and the mother-infant bond; these factors should be investigated further to establish whether mechanisms exist.
Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report
Authors: Zheng Jasper X. , Betts Elham Vali , Dwyre Denis M. , Chung Jong H. , Mitra Ananya Datta 
Published: May 2023

Abstract
Background:
Herein, we present the second documented case of a rare pediatric lower extremity unilateral unilocular cutaneous BPDCN in a relatively asymptomatic Hispanic child who had unusual initial transient improvement from antibiotic treatment.
Case presentation:
A well-nourished 12-year-old Hispanic male with no significant past medical history developed a sizable progressively enlarging lesion on his right inner calf of approximately two months duration after a ground level fall. Review of systems noted night sweats. All imaging findings were unremarkable except for subcutaneous soft tissue ill-defined infiltrative swelling. Routine laboratory findings were non-contributory. The differential of chronic atypical infectious etiology was initially favored. Interestingly, it did have transient improvement with drainage and antibiotic treatment (Cephalexin/Keflex, 500mg). Approximately two months later, the lesional appearance worsened and patient was eventually diagnosed with blastic plasmacytoid dendritic cell neoplasm.
Conclusion:
Pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive neoplastic process involving precursor plasmacytoid dendritic cells. Diagnostic evaluation of this intricate heterogeneous entity necessitates the incorporation of various clinical and laboratory findings. Given the challenging nature of this entity, it is imperative to arrive at timely diagnosis with tissue biopsy and initiate appropriate prompt management.
Post-migration stressors, mental health and well-being in resettled refugees from Syria: Do individuals’ coping strategies matter?
Authors: Solberg Øivind , Nissen Alexander , Saboonchi Fredrik 
Published: May 2023

Abstract
Background The evidence is mixed as to whether individuals’ coping strategies may mitigate the adverse mental health effects of post-displacement stressors in refugee populations, with some indications that the buffering effects of coping strategies are context dependent. The present study examined if problem-solving and acceptance coping strategies were effect modifiers between post-migration stressors and mental health in adult refugees from Syria resettled in Sweden.Methods Study aims were investigated using cross-sectional survey data from a nationwide, randomly sampled group of adult refugees from Syria resettled in Sweden between 2008 and 2013 (Nsample = 4000, nrespondents = 1215, response rate 30.4%). Post-migration stressors examined included: financial strain, social strain, host-country competency strain and discrimination. Two mental health outcomes were used: anxiety/depression, measured with the Hopkins Symptom Checklist-25; and well-being, measured with the WHO-5 Well-being Index. Both outcomes were modelled continuously. Coping strategies were measured using the BRIEF Cope scale. Interactions between coping strategies and post-migration stressors were tested in fully adjusted linear regression models using Wald test for interaction, corrected for multiple testing using the Benjamini-Hochberg procedure.Results Both problem-solving and acceptance coping strategies buffered the adverse association between financial strain and symptoms of anxiety/depression, and problem-solving coping strategies buffered the adverse association between host-country competency strain and anxiety/depression.Conclusions The study suggests that individuals’ coping strategies may to some degree buffer the adverse mental health effects of financial strain and host-country competency strain experienced by refugees in the resettlement phase. Although this pattern was only found in regard to anxiety/depression and not subjective well-being, the findings show that individual-level coping skills among refugees may contribute to adaptation in the face of post-settlement adversities. Notwithstanding the importance of attending to refugees’ psychosocial conditions, refugees residing in refugee camps and newly resettled refugees might benefit from interventions aiming at enhancing individual coping resources and skills. The potential effect of increased controllability and decreased conflict-proximity also warrants further exploration in future studies
The formation of oscillation patterns based on the planetary gravitational field and their suitability for earthquake prediction.
Authors: Nitsche Michael 
Published: May 2023

Abstract
The fluctuating planetary gravitational field influences not only activities on the Sun but also on the Earth. A special correlation function describes the harmonics of these fluctuations. Groups of earthquakes form oscillation patterns that differ significantly from randomly chosen control groups. These patterns are suitable as an element of an AI for the probability of earthquakes.
In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma
Authors: Li Li , Xing Tao , Chen Yiran , Xu Weiran , Fan Bo , Ju Gaoda , Zhao Jing , Lin Li , Yan Cihui , Liang Jun , Ren Xiubao 
Published: May 2023

Abstract
Interferon gamma (IFN-γ) exerts anti-tumor effects by inducing ferroptosis. Based on CRISPR/Cas9 knockout screening targeting genome-wide protein encoding genes in HepG2 and SK-Hep-1 cell lines, we found that cAMP response element binding protein (CREB) regulated transcription coactivator3 (CRTC3) protects tumor cells from drug induced ferroptosis and significantly inhibits the efficacy of IFN-γ treatment in hepatocellular carcinoma (HCC). Mechanistically, CRTC3 knockout altered tumor cell lipid patterns and increased the abundance of polyunsaturated fatty acids (PUFAs), which enables lipid peroxidation and enhances the susceptibility of HCC cells to ferroptosis inducers. To scavenge for accumulated lipid peroxides (LPO) and maintain redox equilibrium, HCC cells up-regulate SLC7A11 expressions to enhance the activities of glutamate-cystine antiporter (system xc-). As IFN-γ inhibiting system xc-, simultaneous treatment with IFN-γ disrupts the compensatory mechanism, and generates a synergistic effect with CRTC3 knockout to facilitate ferroptosis. Sensitizing effects of CRTC3 depletion were confirmed using typical ferroptosis inducers, including RSL3, erastin and Sorafeinib. In conclusion, CRTC3 is involved in regulation of PUFAs metabolism and ferroptosis. Targeting CRTC3 signaling in combination with ferroptosis inducers present a viable approach for HCC treatment and overcoming drug resistance.
Early Earth microbial metallome: Insights from Cd, Ba, and Ni isotopes in stromatolites
Authors: Hohl Simon , Lv Yiwen , Viehmann Sebastian , Lin Yi-Bo , Jiang Yuxiang , Zhang Yinggang 
Published: May 2023

Abstract
Stromatolitic carbonates are geochemical archives that allow studying the long-term interplay of the biosphere, atmosphere, and hydrosphere through deep time, with the unique potential to investigate early life environments and the evolution of the metallome. Recently non-traditional stable isotopes of bioactive metals emerged as novel proxies to reconstruct the micronutrient cycling in stromatolitic microbial habitats.
This study uses stromatolites from the ~3-billion-year-old Pongola Supergroup (S.-Africa) as a field laboratory for combined in-situ trace metal mapping and layer-specific novel stable metal isotope compositions to determine biogeochemical metal cycling in early Earth microbial habitats. LA ICP-MS maps reveal intrinsic bio-sedimentary enrichments of Ni, Cd, P, Fe and Mn in laminae; in contrast, Ba shows a more heterogeneous distribution. Intra-laminae δ60Ni and δ112Cd follow typical kinetic isotopic fractionation, i.e., the isotopic composition of Cd and Ni evolves to heavier values with decreasing respective element concentrations arguing for carbonate precipitation from a fractionated Ni and Cd pool heavier than ambient silicate rocks. Further correlations of δ112Cd with δ13C and the nutrients Cu, Mo, and P argue for primarily photosynthetic over methanogenic metal uptake. In contrast, δ138Ba records isotope fractionation related to variable aragonite precipitation rates in the stromatolite, i.e., Ba evolves to isotopically heavier values with increasing concentrations under variable alkalinity in the microbial habitat. We show that the combination of Cd and Ni isotopes has unique potential as novel isotope biomarker for early Earth's bio-chemical sediment record where traditional lipid biomarkers are not applicable due to fragmentary preservation of organic material.
Primary Bone Diffuse Large B-cell Lymphoma (PB-DLBCL) – a distinct extranodal lymphoma of germinal center origin, with an EZB-like mutational profile and good prognosis
Authors: Ivanova Vanesa-Sindi , Davies John , Menter Thomas , Wild Damian , Müller Anne , Krasniqi Fatime , Stenner Frank , Papachristofilou Alexandros , Dirnhofer Stefan , Tzankov Alexandar 
Published: May 2023

Abstract
Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is not recognized as a separate entity by the current classification systems. Here, we define and highlight its distinctive clinical presentation, morphology, phenotype, gene expression profile (GEP) and molecular genetics.
We collected 27 respective cases and investigated their phenotype, performed gDNA panel sequencing covering 172 genes, and carried out fluorescence in situ hybridisation to evaluate MYC, BCL2 and BCL6 translocations. We attempted to genetically subclassify cases using the Two-step classifier and performed GEP for cell-of-origin subtyping and in silico comparison to uncover up- and down-regulated genes as opposed to other DLBCL.
Almost all cases (n=22) were germinal center B-cell-like (GCB) by immunohistochemistry and all by GEP. Additionally, PB-DLBCL has a mutational profile similar to follicular lymphoma and nodal GCB-DLBCL, with the exception of TP53 and B2Mmutations. The GEP of PB-DLBCL is unique, and the frequency of BCL2rearrangements is lower compared to nodal GCB-DLBCL. The Two-step classifier categorised 8 of the cases as EZB, 3 as ST2 and 1 as MCD.
This study comprehensively characterizes PB-DLBCL as a separate entity with distinct clinical and morpho-molecular features. These insights may aid in developing tailored therapeutic strategies and shed light on its pathogenesis.
Evaluation of awareness about common eye diseases related to electronic devices use and their risk factors among Syrian university students
Authors: a'raji Zeinab Al , Asadi Natalie Al , Hedde Yusra 
Published: May 2023

Abstract
Introduction: All of us are exposed on a daily basis to many visible and sometimes invisible lights that can cause many damages and risks to our health and the health of those around us. These range from damage to the retina to potential vision loss. So, blue light is one of the factors affecting human health. Blue light is part of the visible light spectrum and consists of electromagnetic particles that travel in waves. These waves emit energy and vary in length and strength. Blue light has a wavelength between about 380 and 500 nanometers, making it one of the shortest and longest wavelengths of energy. This type of waves is emitted from electronic devices. This study aims to determine the awareness of the effects of the waves emitted from electronic devices on the human eye.
Materials and Methods: A descriptive cross-sectional study was conducted on a group of students. We obtained a written consent from all patients in the group. All patients were university students. The study excluded patients who didn’t complete the questionnaire. The study was approved by the Ethical Review Board (IRB) of the Faculty of Medicine in the Syrian Private University.
Results: Out of 1009 students participating in the study, 18.2% were students in the field of human medicine, 28.6% were students in dentistry, 13.5% were students in pharmacy, 16.4% were students in engineering, and 11.1% were students in business administration. 29.3% of the participants were Damascus University students, 39% were Syrian Private University students, and 14.7% were Al-Sham Private University students. 58.1% of the study subjects stated that they relied on the use of electronic lectures in the study, compared to 41.9% who relied on paper lectures.
Conclusion: Additional studies are needed to identify the harm of blue rays that are emitted from electronic devices on the eyes. As well as the need to determine the knowledge and awareness of the harm of light on the eyes.
Spatial distribution and ecological niche modelling of some potential vectors involved in the transmission of Buruli ulcer in Benin (West Africa)
Authors: Pérugine AKOTON Tété , Kourouma KOURA , Jean GANGLO Cossi 
Published: May 2023

Abstract
Buruli Ulcer (BU) is an infectious disease caused by a pathogen, Mycobacterium ulcerans. This mycobacterium is responsible for severe necrosis of subcutaneous tissue leading to chronic ulcers and wounds. However, the distribution of potential reservoirs of this mycobacterium, which is necessary for an effective dynamics control, remains poorly known in Benin. This study aims to model the spread of BU infection risk in Benin. The methodological approach focused on data collection, processing and analysis. Indeed, two data sources were used in the MaxEnt (Maximum Entropy) software to model the spatial distribution of some families of Mycobacterium ulcerans vectors. These are present and future bioclimatic data (scenarios rcp 45 and rcp 85) downloaded from http://webfiles.york.ac.uk/KITE/AfriClim/ and occurrences (234) of the disease from fieldwork and literature. Potential vectors inventoried in the field are aquatic bugs of the family Belostomatidae and Naucoridae and worms whose taxa were not specified. The areas at risk of this disease in the present as well as in the future, globally include the South to the Center Benin and parts of the North-West and North-East of the country. The various results obtained are valuable for prevention and better management of patients. To this end, it will be necessary to focus attention and strengthen control interventions in areas at present and future risk of the disease.
Pseudo(-) in French and Greek: Categorization and approximation
Authors: Vassiliadou Hélène , Gerhard-Krait Francine , Fotiadou Georgia , Lammert Marie 
Published: May 2023

Pseudo(-) is generally considered to be a prefix or a prefixoid unit with an evaluative value of pragmatic approximation and negative polarity: pseudo(-)X presents a distortion with respect to a standard X. It then enters the paradigm of expressions responsible for infusing subjectivity into the discourse. The interpretative mechanisms in play exploit two dimensions, semantic and pragmatic, according to principles that will be explained in this paper. Furthermore, our contribution aims to highlight the semantic dimension in the interpretation of pseudo(-) both in Greek and French and to show how it exploits the semantic and categorial properties of the nouns that are postposed to it, leading to three main types of categorization (pseudo(-)X belongs to the category X but it is not a good exemplar, pseudo(-)X is clearly not an X the categorization remains undecidable) and to several readings.
PENGARUH RASIO LIKUIDITAS, RASIO SOLVABILITAS DAN PROFITABILITAS TERHADAP NILAI PERUSAHAAN SEKTOR INFRASTRUKTUR YANG TERDAFTAR DI BEI TAHUN 2017-2020
Authors: Yulanda Maya Valentina , Sari Nadia Roosmalita 
Published: May 2023

Infrastructure companies are companies that contribute to development, this type of company also has good prospects, especially in the global capital market. So in this case a company wants its business to be sustainable and therefore always tries to manage its finances by obtaining, allocating and using it efficiently and effectively, as well as improving the quality of new products and investments. This study aims to determine the effect of liquidity, solvency and profitability on firm value in infrastructure sector companies listed on the Indonesia Stock Exchange in 2017-2020. The method used is a quantitative approach and multiple linear regression analysis, while for the determination of the sample using the purposive sampling method with certain criteria, the number of samples is 10 companies. Testing this data using SPSS 16 software. The results showed that liquidity had no effect on firm value, solvency had a significant effect on firm value, and profitability had a significant effect on firm value.
The Chimera of TPGS and Nanoscale Lipid Carriers as Lymphatic Drug
Delivery Vehicles to Fight Metastatic Cancers
Authors: Sherif Abdelrahman Y. , Harisa Gamaleldin I. , Alanazi Fars K. 
Published: May 2023

Abstract:
The lymphatic system (LS) plays a crucial role in fluid balance, transportation of macromolecules,
and immune response. Moreover, LS is a channel for microbial invasion and cancer metastasis.
Particularly, solid tumors, including lung, breast, melanoma, and prostate cancers, are metastasized
across highways of LS. Subsequently, the fabrication of chimeric lymphatic drug delivery systems
(LDDS) is a promising strategy to fight cancer metastasis and control microbial pandemics. In this regard,
LDDS, in terms of PEG-nanoscaled lipid carriers, elicited a revolution during the COVID-19 pandemic
as cargoes for mRNA vaccines. The drug delivered by the lymphatic pathway escapes first-pass
metabolism and enhances the drug's bioavailability. Ample approaches, including synthesis of prodrugs,
trigging of chylomicron biosynthesis, and fabrication of nanocarriers, facilitate lymphatic drug delivery.
Specifically, nanoscales lipid cargoes have the propensity to lymphatic trafficking. Interestingly, TPGSengineered
nanoscale lipid cargoes enhance lymphatic trafficking, increase tissue permeation, and, specifically,
uptake. Moreover, they overcome biological barriers, control biodistribution, and enhance
organelles localization. Most anticancer agents are non-specific, have low bioavailability, and induced
drug resistance. Therefore, TPGS-engineered nanoscale lipid chimeras improve the therapeutic impact
of anticancer agents. This review highlights lymphatic cancer metastasis, nanoscales lipid cargoes as
LDDS, and their influence on lymphatic trafficking, besides the methods of LDD studies.