bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prognostic differences and the effect of postmastectomy radiotherapy between post‐chemotherapy ypT1‐2ypN1 and de novo pT1‐2N1 breast cancer
Authors: Yang Tian , Zhong Xiaorong , Wang Jun , Xiang Zhongzheng , Zeng Yuanyuan , Yu Siting , Dai Zelei , Xu Ningyue , Luo Ting , Liu Lei 
Published: February 2023

AbstractBackgroundThe prognosis and the value of postmastectomy radiotherapy (PMRT) between post‐chemotherapy ypT1‐2ypN1 and de novo pT1‐2N1 breast cancer (BC) remain controversial. We aimed to evaluate the prognostic differences and the effect of PMRT between the two patient subsets.MethodsPatients diagnosed with pT1‐2N1M0 BC were identified between 2010 and 2018. The study endpoints were overall survival (OS), breast cancer‐specific survival (BCSS), locoregional recurrence‐free survival (LRFS), distant metastasis‐free survival (DMFS) and disease‐free survival (DFS). The chi‐square test, Kaplan–Meier method and Cox regression analysis were used for data analysis.ResultsTotal number of 2103 pT1‐2N1M0 BC patients were included in the study, including 270 post‐chemotherapy (97 without PMRT, 173 with PMRT) and 1833 de novo cases (993 without PMRT, 840 with PMRT). No significant differences were found between post‐chemotherapy ypT1‐2ypN1 and de novo pT1‐2N1 BC patients in 5‐year OS (p = 0.068), BCSS (p = 0.054), LRFS (p = 0.241), DMFS (p = 0.104) or DFS (p = 0.08). PMRT did not improve any survival outcome in patients receiving neoadjuvant chemotherapy; however, the PMRT group had a better 5‐year BCSS (97.0% vs. 95.8%, p = 0.033) in de novo pT1‐2N1 BC. Cox multivariate analysis demonstrated that PMRT was a significant independent predictor of BCSS (HR 0.628; 95% CI, 0.403–0.978; p = 0.04) in de novo pT1‐2N1 patients.ConclusionsThere seemed no survival difference in post‐chemotherapy ypT1‐2ypN1 and de novo pT1‐2N1 BC patients with contemporary systemic therapy. In addition, PMRT might be exempted in patients with post‐chemotherapy ypT1‐2ypN1 BC, while not in patients with de novo pT1‐2N1 BC.
Surgical management of gingival recessions in patients with refractory gingival pemphigus vulgaris: A multidisciplinary challenge
Authors: Gabusi Andrea , Stefanini Martina , Gissi Davide Bartolomeo , Rossi Roberto , Sangiorgi Matteo , Loi Camilla , Filippi Federica , Montebugnoli Lucio , Zucchelli Giovanni , Bardazzi Federico 
Published: February 2023

AbstractBackgroundMucogingival surgery for root coverage of gingival recessions (GRs) is usually performed in patients with unremarkable periodontal and systemic health. However, the predictable results of surgical procedures and increasingly high aesthetic expectations of patients necessitate optimal management of GR also in patients with systemic conditions that affect the oral cavity. In patients with pemphigus vulgaris (PV), mucosal fragility and complicated surgical management of inflamed soft tissues are major challenges.Methods and ResultsA 36‐year‐old female patient with PV and deep GR on the mandibular incisors is presented. After initial unresponsiveness to steroids and immunosuppressants, complete clinical remission was achieved through repeated rituximab infusions and topical platelet‐rich plasma. After > 1 year of stable clinical remission off therapy the patient successfully underwent surgical procedures for vertically coronally advanced flap with connective tissue graft.ConclusionsTo the best of our knowledge, no studies have described the surgical management of GR in PV patients. Although controlled studies are required to confirm present results, complete and stable clinical remission is necessary to avoid complications. Collaboration among dermatologists, oral medicine specialists, and periodontologists is essential to determine whether mucogingival surgery for root surface exposure is indicated for PV patients.Key pointsWhy are these cases new information?

This is the first report of root coverage in a patient with oral PV
What are the keys to the successful management of these cases?

The achievement of complete and stable clinical remission from oral PV
Multidisciplinary collaboration among dermatologists, oral medicine specialists, and periodontologists
What are the primary limitations to success in these cases?

The refractoriness of gingival lesions induced by PV
Poor mucogingival conditions of inflamed gingival tissues exacerbated by PV
Spontaneous extradural hematoma in a Sickle cell Beta Thalassemia patient—A rare complication
Authors: Ghimire Prasanna , Ghimire Pragya Gautam 
Published: February 2023

AbstractSpontaneous extradural hematoma in Sickle cell disease is rare neurological complication with few cases reported in the English literature. We report a case of a 16‐year‐old male patient who was previously diagnosed with Sickle Cell Beta Thalassemia and presented with severe headache and vomiting for 3 days. An emergency CT scan of the head demonstrated right‐sided acute parietal extradural hematoma with mass effect. Patient underwent emergent craniotomy with evacuation of the hematoma. Patient recovered completely. Although calvarial infarction has been associated with extradural hematoma, an absence of it makes our case distinct. A high index of suspicion should be made in SCD patients for possibility of EDH in progressive headache.
Aqueous Binders Compatible with Ionic Liquid Electrolyte for High‐Performance Aluminum‐Ion Batteries
Authors: Yang Zhaohui , Guo Meilin , Meng Pengyu , Jiang Min , Qiu Xiangyun , Zhang Jiao , Fu Chaopeng 
Published: February 2023

AbstractThe incompatibility of poly(vinylidene difluoride) (PVDF) with acidic ionic liquid electrolytes and the use of toxic and high‐cost N‐methyl pyrrolidone (NMP) solvents hinder the wide application of aluminum‐ion batteries (AIBs). In this work, sodium alginate (Na−Alg) is developed as an aqueous binder for the fabrication of graphite positive electrodes in AIBs. The compatibility of various binders with the ionic liquid electrolyte is evaluated, and interaction between various binders and graphite particles before and after cycling is compared and discussed. The results demonstrate that the well compatibility of Na−Alg in ionic liquids and its reasonable distribution on the graphite surface facilitate fast charge transfer and ion diffusion, reduce electrode polarization, and thus contributing to significantly improved cycling stability and rate capability of AIBs. This work provides a new insight into the development of low‐cost, eco‐friendly, and high‐performance binders for AIBs.
Quantum Yield of DNA Strand Breaks under Photoexcitation of a Molecular Ruby
Authors: Wang Cui , Ebel Kenny , Heinze Katja , Resch‐Genger Ute , Bald Ilko 
Published: February 2023

AbstractPhotodynamic therapy (PDT) used for treating cancer relies on the generation of highly reactive oxygen species, for example, singlet oxygen1O2, by light‐induced excitation of a photosensitizer (PS) in the presence of molecular oxygen, inducing DNA damage in close proximity of the PS. Although many precious metal complexes have been explored as PS for PDT and received clinical approval, only recently, the potential of photoactive complexes of non‐noble metals as PS has been discovered. Using the DNA origami technology that can absolutely quantify DNA strand break cross sections, we assessed the potential of the luminescent transition metal complex [Cr(ddpd)2]3+(ddpd=N,N′‐dimethyl‐N,N′‐dipyridine‐2‐ylpyridine‐2,6‐diamine) to damage DNA in an air‐saturated aqueous environment upon UV/Vis illumination. The quantum yield for strand breakage, that is, the ratio of DNA strand breaks to the number of absorbed photons, was determined to 1–4 %, indicating efficient transformation of photons into DNA strand breaks by [Cr(ddpd)2]3+.
Activatable Fluorescent Probes Targeting Urokinase‐Type Plasminogen Activator Receptor on the Cell Membrane
Authors: Kim Tae‐Il , Cho Siyoung , Jin Hanyong , Bae Jeehyeon , Park Chanhee , Kim Youngmi 
Published: February 2023

AbstractUrokinase‐type plasminogen activator receptor (uPAR) is a glycolipid‐anchored protein located on the cell surface that is implicated in the promotion of metastasis. New fluorescent probes for the detection of uPAR expression that feature a rapid “turn‐on” response are reported here. They consist of a donor‐π‐acceptor‐based fluorophore conjugated with a uPAR‐binding AE105 peptide. The resulting AE105‐coupled uPAR‐targeting probes are weakly emissive in aqueous buffer solutions; however, a fluorescence “turn‐on” signal is instantly triggered upon specific binding to uPAR (KD=63.2 nM for P1 and 49.5 nM for P2), which restricts the rotational deactivation of the fluorophore. Applications of the probes were demonstrated in the imaging of uPAR overexpressed on the membrane of cancer cell and in a cell‐based uPAR inhibitor assay.
Functionalized Benzothiadiazole Non‐Fused A−D−A’−D−A Small Molecules for Effective Electron Mobilities and Metal‐free Photocatalysis
Authors: Pratap Tripathi Narendra , Gupta Vidushi , Tarun Tarun , Kumar Pandey Upendra , Sengupta Sanchita 
Published: February 2023

AbstractThree non‐fused A−D−A’−D−A π‐conjugated metal‐free small molecules BT‐IT1, BT‐IBT2 and BT2F‐IBT3 have been synthesized and their absorption characteristics and redox properties, as well as charge carrier mobilities have been investigated. The resultant molecules exhibited broad absorption in the range of 325–600 nm in solutions and in thin films the absorption range is 350–700 nm. These new conjugated small molecules showed low‐lying HOMO energy levels (−5.49 to −5.50 eV), deep LUMO energy levels (−3.67 to −3.69 eV) and narrow bandgaps of (EgCV) ∼0.79 eV. Appreciable electron mobilities for compounds BT‐IBT2 and BT2F‐IBT3 were 4.56×10−3 and 1.12×10−3 cm2 V−1 s−1, respectively, obtained by space‐charge limited current (SCLC) measurements. Additionally, excellent photocatalytic performances of BT‐2T (6), BT2F‐2T (10), BT‐IT1, BT‐IBT2 and BT2F‐IBT3 for highly selective oxidation of thioanisole to desired sulfoxides under visible light irradiation were observed.
Design and simulation of a novel solar photovoltaic system assisted single‐slope solar still distillation unit
Authors: Migaybil Hashim H. , Maddah Hisham A. , Gopaluni Bhushan 
Published: February 2023

AbstractWater is an essential component of our lives. Conventional seawater desalination, based on fossil fuel energy, is primary in meeting freshwater demands. Thus, solar desalination still emerged as an alternative technology that employs environmentally friendly renewable energy. Here, we aim to design and simulate a novel hybrid solar photovoltaic (PV) system coupled with a single‐slope solar still unit for freshwater production. Various design techniques were utilized to fine‐tune the model towards producing 3–4.6 kg/m2 · day of distillate water, thereby calculating the design aspects such as tank size, energy, and cost. The results revealed that a conventional solar desalination system had 22% lower efficiency than the proposed novel still distillation unit assisted with a solar PV system (connected to a heating element). The maximum efficiency of 45% has been recorded at the peak solar insolation due to the combination of the solar PV system. According to our design constraints, only a 3 m2 basin area was required to achieve a productivity of = 1–5 kg/day. Design analysis showed that the total capital cost of a conventional still can be significantly reduced from 2600 to 1500 $/unit with PV system integration at the specified productivity and optimal solar radiation of ~17 MJ/m2 · day at peak time (02.00 PM). This work paves the way towards maximizing solar energy utilization from PV integration with solar desalination to achieve high freshwater productivity in single‐basin solar still systems.
Structurally Diverse Sesquiterpenoids from Chloranthus henryi var. hupehensis and Their Anti‐inflammatory Activities
Authors: Zhang Dan‐Yang , Hu Yun‐Ran , Yang Hui , Wang Ya‐Nan , Liu Shuai , Zou Yun‐He , Zhou Jing‐Jing , Zhuang Peng‐Yu , Wang Xiao‐Xia , Liu Hang 
Published: February 2023

Comprehensive SummaryIn this study, 27 new sesquiterpenoids: twenty monomers and seven dimers, with diverse structures, along with one known chlorajaponilide F (25) were isolated from the aerial parts of Chloranthus henryi var. hupehensis. Structurally, chlorahupetolides A (1) and B (2), two eudesmane‐type merosesquiterpenoids with an undescribed C18 carbon framework, and chlorahupetene E (18) are the first example of dimers comprising two eudesmane sesquiterpenoids bridged by a four‐membered ring in the Chloranthus. Their structures were characterized by nuclear magnetic resonance (NMR), electronic circular dichroism (ECD), and X‐ray diffraction analysis. In the RAW264.7 macrophages model of inflammation induced by LPS, compounds 12, 18, and 25 significantly reduced NO production in a dose dependent manner and without cytotoxicity. The mRNA expression of COX‐2 was considerably inhibited by treatments with compounds 12, 18, and 25.
Acridine/Acridone–Carborane Conjugates as Strong DNA‐Binding Agents with Anticancer Potential
Authors: Różycka Daria , Kowalczyk Aleksandra , Denel‐Bobrowska Marta , Kuźmycz Olga , Gapińska Magdalena , Stączek Paweł , Olejniczak Agnieszka B. 
Published: February 2023

AbstractSynthesis of acridine derivatives that act as DNA‐targeting anticancer agents is an evolving field and has resulted in the introduction of several drugs into clinical trials. Carboranes can be of importance in designing biologically active compounds due to their specific properties. Therefore, a series of novel acridine analogs modified with carborane clusters were synthesized. The DNA‐binding ability of these analogs was evaluated on calf thymus DNA (ct‐DNA). Results of these analyses showed that 9‐[(1,7‐dicarba‐closo‐dodecaborane‐1‐yl)propylamino]acridine (30) interacted strongly with ct‐DNA, indicating its ability to intercalate into DNA, whereas 9‐[(1,7‐dicarba‐closo‐dodecaborane‐1‐yl)propanamido]acridine (29) changed the B‐form of ct‐DNA to the Z form. Compound 30 demonstrated cytotoxicity, was able to inhibit cell proliferation, arrest the cell cycle in the S phase in the HeLa cancer cell line, and induced the production of reactive oxygen species (ROS). In addition, it was specifically localized in lysosomes and was a weak inhibitor of Topo IIα.
Color, light, and birth space design: An integrative review
Authors: Balabanoff Doreen 
Published: February 2023

AbstractThis integrative review sought knowledge across a broad spectrum of literature concerning the role of color and light in maternity environments. Today it is acknowledged that the clinical nature of birth spaces is detrimental to maintaining normal physiological birth rates. Significantly, “clinical” spaces are often described as white, pale, monochromatic, and/or overlit. Attempts to make maternity settings more “home‐like” have promoted use of “warm” or “soft” colors. Ambience or spatial atmosphere is known to impact birth hormones, affecting labor commencement and progress. Today, efforts to improve birth spaces include “sensory rooms” (offering pain distraction via dark spaces and illuminated color elements); programmable colored light installations; and immersive image projections. Yet, as this paper shows, there is little specific study of the physical and psychological impact of color and light within birth settings. However, there are significant findings on colored light's impact upon birth processes, including the contraindication of bright blue light. And there is valuable knowledge embedded in old and new literature from diverse disciplines. This review thus exposes the strong need for further research and literature focused directly on how color and light in birth environment design impact birth experience for all involved. It is clear that environmental color and light need to be taken seriously as potent interrelated environmental factors that are directly implicated in the health and wellness of mothers and their infants during labor and birth. Thus, it is crucial to bring deeper awareness and comprehensive knowledge into use by designers, developers and managers of birth spaces.
Inbred phenotypic data and non‐additive effects can enhance genomic prediction models for hybrid grain sorghum
Authors: Crozier Daniel , Leon Fabian , Fonseca Jales M. O. , Klein Patricia E. , Klein Robert R. , Rooney William L. 
Published: February 2023

AbstractImplementation of genomic prediction can bolster rates of genetic gain in sorghum improvement and permit more efficient allocation of resources within hybrid breeding programs. In the present study, alternative genomic prediction models were compared to assess the potential benefits of including inbred phenotypic records, dominance effects, and genotype‐by‐environment (G×E) interactions in predicting hybrid grain sorghum performance. Comparisons were made in a set of 395 hybrid combinations derived from 92 parental inbred lines tested in a sparse multi‐environment trial. Phenotypic data were collected on hybrids and inbreds for days to mid‐anthesis, grain yield, and plant height, and genomic data on parental inbreds were collected by genotyping × sequencing. A significant increase in prediction accuracy was observed when modeling G×E effects; however, dominance effects did not contribute to the overall predictive ability of models in this data set. Including phenotypic data from parental lines significantly improved the prediction of hybrid merit by as much as 17% for days to mid‐anthesis, 14% for grain yield, and 33% for plant height when there were no testcross records for a given parental line. Alternatively, similar improvements were not as consistent when the training set included lines already tested in hybrid combinations. Thus, hybrid crop breeders can further optimize genomic predictions for un‐testcrossed lines by including non‐additive effects and inbred data.
Intravenous iron infusion in patients with heart failure: a systematic review and study‐level meta‐analysis
Authors: Salah Husam M. , Savarese Gianluigi , Rosano Giuseppe M.C. , Ambrosy Andrew P. , Mentz Robert J. , Fudim Marat 
Published: February 2023

AbstractAimsThere is considerable variability in the effect of intravenous iron on hard cardiovascular (CV)‐related outcomes in patients with heart failure (HF) in randomized controlled trials (RCTs). We use a meta‐analytic approach to analyse data from existing RCTs to derive a more robust estimate of the effect size of intravenous iron infusion on CV‐related outcomes in patients with HF.Method and resultsPubMed/Medline was searched using the following terms: (‘intravenous’ and ‘iron’ and ‘heart failure’) from inception till 6 November 2022 for RCTs comparing intravenous iron infusion with placebo or standard of care in patients with HF and iron deficiency. Outcomes were the composite of CV mortality and first hospitalization for HF; all‐cause mortality; CV mortality; first hospitalization for HF; and total hospitalizations for HF. Random effects risk ratio (RR) with 95% confidence intervals (CIs) were calculated. Ten RCTs with a total of 3438 patients were included. Intravenous iron resulted in a significant reduction in the composite of CV mortality and first hospitalization for HF [RR 0.0.85; 95% CI (0.77, 0.95)], first hospitalization for HF [RR 0.82; 95% CI (0.67, 0.99)], and total hospitalizations for HF [RR 0.74; 95% CI (0.60, 0.91)] but no statistically significant difference in all‐cause mortality [RR 0.95; 95% CI. (0.83, 1.09)] or CV mortality [OR 0.89; 95% CI (0.75, 1.05)].ConclusionsIntravenous iron infusion in patients with HF reduces the composite risk of first hospitalization for HF and CV mortality as well as the risks of first and recurrent hospitalizations for HF, with no effect on all‐cause mortality or CV mortality alone.
The miR‐124‐3p regulates the allergic airway inflammation and remodeling in an ovalbumin‐asthmatic mouse model by inhibiting S100A4
Authors: Liu Min , Liu Shuang , Li Fajiu , Li Chenghong , Chen Shi , Gao Xiaoyan , Wang Xiaojiang 
Published: February 2023

AbstractObjectiveAsthma is a chronic respiratory disease with an increasing incidence every year. microRNAs (miRNAs) have been demonstrated to have implications for asthma. However, limited information is available regarding the effect of miR‐124‐3p on this disease. Therefore, this study aimed to explore the possible effects of miR‐124‐3p and S100A4 on inflammation and epithelial–mesenchymal transition (EMT) in asthma using mouse models.MethodOvalbumin was used to induce asthmatic mouse models. Lung injury in mouse models was assessed, and the bronchoalveolar lavage fluid of mice was collected to determine the number of eosinophilic granulocytes and assess inflammation. The expression levels of miR‐124‐3p, S100A4, E‐cadherin, N‐cadherin, Snail1, vimentin, and TGF‐β1/Smad2 signaling pathway‐related proteins were measured using reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) and western blot analysis. In vitro experiments, cells were transfected with miR‐124‐3p mimics or inhibitors to test the expression of S100A4 by RT‐qPCR and western blot analysis, and the mutual binding of miR‐124‐3p and S100A4 was validated by dual‐luciferase reporter gene assay.ResultsOverexpression of miR‐124‐3p or inhibition of S100A4 expression attenuated bronchial mucus secretion and collagenous fibers and suppressed inflammatory cell infiltration. Additionally, upon miR‐124‐3p overexpression or S100A4 suppression, eosinophilic granulocytes were decreased, interleukin‐4 (IL‐4) and IL‐13 expression levels were reduced in the bronchoalveolar lavage fluid, serum total IgE level was reduced, and the TGF‐β1/Smad2 signaling pathway was suppressed. Mechanically, a dual‐luciferase reporter gene assay verified the binding relationship between miR‐124‐3p and S100A4.ConclusionmiR‐124‐3p can negatively target S100A4 to attenuate inflammation in asthmatic mouse models by suppressing the EMT process and the TGF‐β/smad2 signaling pathway.
Characterisation of a smoke/ aerosol exposure in vitro system (SAEIVS) for delivery of complex mixtures directly to cells at the air‐liquid interface
Authors: Wieczorek Roman , Trelles Sticken Edgar , Pour Sarah Jean , Chapman Fiona , Röwer Karin , Otte Sandra , Stevenson Matthew , Simms Liam 
Published: February 2023

AbstractIn vitro testing is important to characterise biological effects of consumer products, including nicotine delivery products such as cigarettes, e‐cigarettes and heated tobacco products. Users' cells are exposed to these products' aerosols, of variant chemical compositions, as they move along the respiratory tract. In vitro exposure systems are available to model such exposures, including delivery of whole aerosols to cells, and at the air‐liquid interface. Whilst there are clear advantages of such systems, factors including time to aerosol delivery, aerosol losses and number of cell cultures that can be exposed at one time could be improved. This study aimed to characterise a custom‐built smoke/ aerosol exposure in vitro system (SAEIVS) using 1R6F reference cigarette smoke. This system contains five parallel smoking chambers and delivers different dilutions of smoke/ aerosol to two separate cell culture exposure chambers in <10 s. Using two dosimetry measures (optical density 400 nm [OD400]; mass spectrometric nicotine quantification), the SAEIVS demonstrated excellent linearity of smoke dilution prior to exposure (R2 = 0.9951 for mass spectrometric quantification; R2 = 0.9965 for OD400) and consistent puff‐wise exposures across 24 and 96 well plates in cell culture relevant formats (e.g., within inserts). Smoke loss was lower than previously reported for other systems (OD400: 16%; nicotine measurement: 20%). There was good correlation of OD400 and nicotine measurements, indicating that OD was a useful surrogate for exposure dosimetry for the product tested. The findings demonstrated that the SAEIVS is a fit‐for‐purpose exposure system for the reproducible dose‐wise exposure assessment of nicotine delivery product aerosols.