bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimum phase Properties Based on High-Gain Output Feedback Stability Analysis
Authors: Foghahaayee Hoda Nokhbeh , Menhaj Mohammad Bagher 
Published: March 2023

Abstract
In this paper, a new definition of the minimum phase property based on high gain output feedback stability (HGS) is introduced. The minimum phase systems with respect to this definition have stable inverses leading to no performance limitations. In other words, the minimum norm of regulation or tracking error for these systems approaches zero. This set of minimum phase linear systems includes systems with stable zeros (i.e., the zeros with negative real parts and/or simple imaginary zeros); however, the usual definition of minimum phase systems considers only systems with zeros located in the open left half plane (LHP). The difficulty of minimum phase determination in nonlinear systems highlights better the main objective of the paper to look for a way to modify the minimum phase concept in some extent to obtain more feasible conditions, which can be applied to a larger class of systems. It should be noted that based on this new definition, the minimum phase determination can be easily checked out through stability analysis of the closed loop system. Furthermore, knowing the fact that both performance limitation and stable inverse criteria can be potentially extended to nonlinear systems, this paper employs these concepts to reflect better the strength of the proposed minimum phase property. Finally, we apply the proposed method to two nonlinear systems. The simulation results easily approve the effectiveness of the method developed fully in the paper.
Efficient Integer Retrieval from Unordered Compressed Sequences
Authors: Zavadskyi Igor 
Published: March 2023

Abstract
We investigate the problem of fast direct access to elements of an integer sequence given in a compressed form. If integers are sorted in ascending order, it can be reduced to performing the 'select' operation on a bitmap, which is very well investigated. We focus on more general and more complicated case of unordered integer sequence and propose to represent it with the help of variable-length Reverse Multi-Delimiter (RMD) codes. When applied to data compression, these codes combine a good compression ratio with fast decoding. In this paper, another property of RMD-codes is researched - the ability of direct access to codewords in the encoded bitstream. We present the method allowing us to extract and decode a codeword from an RMD-bitstream in almost constant time and make experiments on its application to natural language text compression. Due to properties of RMD-codes and compactness of auxiliary direct access structures our method appears to be very space efficient requiring only a few percent excess over the entropy.
Is preoperative hypoalbuminaemia or hypoproteinaemia a reliable marker for anastomotic leakage risk in patients undergoing elective colorectal surgery in an Enhanced Recovery after Surgery (ERAS) program?
Authors: Choi Joseph Do Woong , Kwik Charlotte , Vivekanandamoorthy Nurojan , Shanmugalingam Aswin , Allan Lachlan , Gavegan Fiona , Shedden Karen , Peters Ashleigh , Khoury Toufic El , Pathmanathan Nimalan , Toh James Wei Tatt 
Published: March 2023

Abstract
Purpose: Preoperative hypoalbuminaemia has traditionally been used as a marker of nutritional status and is considered a significant risk factor for anastomotic leak (AL).
Methods: The Westmead Enhanced Recovery After Surgery (WERAS) prospectively collected database, consisting of 361 patients who underwent colorectal surgery with primary anastomosis, was interrogated. Preoperative serum albumin and protein levels (measured within one week of surgery) were plotted on receiver operating characteristic curves (ROC curves) and statistically analysed for cutoff values, sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV).
Results: The incidence of AL was 4.4% (16/361). Overall mortality was 1.4% (5/361), 6.3% (1/16) in the AL group, 1.2% (4/345) in the no AL group. The median preoperative albumin and protein level in the AL group were 39g/L and 75g/L, respectively. The median preoperative albumin and protein level in the no AL group were 38g/L and 74g/L, respectively. Mann Whitney U test showed no statistically significant difference in albumin levels (p = 0.4457) nor protein levels (p = 0.6245) in the AL and no AL groups. ROC curves demonstrated that preoperative albumin and protein levels were not good predictors of anastomotic leak. Cutoff values for albumin (38g/L) and protein (75g/L) both had poor PPV for AL (4.8% and 3.8% respectively).
Conclusion: Preoperative albumin and protein levels in patients undergoing elective colorectal surgery were not reliable independent risk factors for AL. A limitation of this study was that nearly all patients received immune-nutrition or carbohydrate/protein supplementation in the perioperative period as part of an ERAS program.
Gender difference of primary Sjögren’s Syndrome in a Chinese cohort: Why do women suffer more?
Authors: Pu Jincheng , Gao Ronglin , Zhuang Shuqi , Liang Yuanyuan , Wu Zhenzhen , Pan Shengnan , Song Jiamin , Yang Lufei , Zhang Youwei , Wang Xuan , Tang Jianping 
Published: March 2023

AbstractObjective: To analyze gender differences in clinical characteristics of patients with pSS and to identify potential influencing factors.Methods:We analyzed gender differences in clinical variables of 278 pSS patients diagnosed in the Department of Rheumatology and Immunology, Tongji Hospital from January 2010 to December 2020. Then Mendelian randomization (MR) analyses were conducted.Results:92.1% of the 278 pSS patients were women. Women developed the disease earlier and were diagnosed at a younger age. The average age at which women first develop symptoms of pSS was 48.16 years, compared with 57.86 years for men (P= 0.002). Men were diagnosed with pSS on average about 10 years later than women. Females showed a higher complement C3 (P= 0.033), total cholesterol (TC) (P= 0.003), low-density lipoprotein cholesterol (LDL-C) (P= 0.013) and high-density lipoprotein cholesterol (HDL-C) (P= 0.024), while male showed a higher fasting plasma glucose (FPG) (P= 0.013). Females showed a lower incidence of hypertension (P= 0.006), diabetes (P= 0.019), coronary heart disease (P= 0.038), cerebral infarction (P= 0.005) and malignant cancer (P< 0.01). MR-Egger method suggests that the decreased pSS risk was affected by TT (OR = 0.598,P= 0.048) and BT (OR = 0.471,P= 0.032).Conclusion:Females were more likely to develop pSS at an earlier age with fewer comorbidities, which might be closely related to lower levels of testosterone in women. Males showed a higher incidence of hypertension, diabetes, coronary heart disease, cerebral infarction, and malignant cancer.
Gelatin hydrolyzed by papaya latex enzymes as an alternative cryoprotectant for frozen raw Pacific white shrimp (Penaeus vannamei)
Authors: Kittiphattanabawon Phanat , Sri Chodsana , Nalinanon Sitthipong , Visessanguan Wonnop , Benjakul Soottawat 
Published: March 2023

Abstract

The cryoprotective activity of gelatin hydrolyzed by papaya latex enzymes with the degree of hydrolysis (DH) of 5, 10, 15, and 20% was investigated. The cryoprotective activity of gelatin, as determined by thermal hysteresis, increased as DH increased up to 15% (9.14–16.60 °C) and decreased as DH of 20% (11.66 °C). The gelatin hydrolysate with DH of 15% (G15), which showed the highest thermal hysteresis, was subjected to fractionation and cryoprotective effect study in Pacific white shrimp. The fractionated peptide with the highest thermal hysteresis had a molecular weight of 1.7–4.2 kDa (18.81 °C). According to the study of the cryoprotective effect in Pacific white shrimp, the weight of shrimp gained 7.33% after soaking in the G15, which was significantly lower and higher than the weight gain of shrimp treated with mixed phosphates (16.12%) and distilled water (0.82%), respectively (P < 0.05). The shrimp treated with mixed phosphates and G15 had no exudate. The thawing loss of the shrimp treated with distilled water, mixed phosphates, and G15 after the different freeze-thaw cycles ranged from 7.43–9.25, 3.34–3.57, and 3.39–5.39%, respectively. The shrimp treated with G15 and mixed phosphate could retard shrimp quality loss from the freeze-thawing, as noticed by the lower reduction of exudate loss, thawing loss, freezable water content, Ca2+-ATPase activity, and the higher protein solubility than the treatment of water. Therefore, the gelatin hydrolysate could be a potential alternative cryoprotectant in frozen raw shrimp.
Non-reciprocal and Non-Newtonian Mechanical Metamaterials
Authors: Wang Lianchao , Martínez Julio A. Iglesias , Ulliac Gwenn , Wang Bing , Laude Vincent , Kadic Muamer 
Published: March 2023

Abstract
Non-Newtonian liquids are characterized by a stress and velocity-dependent dynamical response. In elasticity, and in particular in the field of phononics, reciprocity in the equations acts against obtaining a directional response for passive media. Active stimuli-responsive materials have been conceived to overcome it. Significantly, Milton and Willis have shown theoretically in 2007 that quasi-rigid bodies containing masses at resonance can display a very rich dynamical behavior, hence opening a route toward the design of non-reciprocal and non-Newtonian metamaterials. In this paper, we design a solid structure that displays unidirectional shock resistance, thus going beyond Newton’s second law in analogy to non-Newtonian fluids. We design the mechanical metamaterial with finite element analysis and fabricate it using 3D printing at the centimetric scale (with fused deposition modeling – FDM) and at the micrometric scale (with two-photon lithography – TPL). The non-Newtonian elastic response is measured via dynamical velocity-dependent experiments. Reversing the direction of the impact, we further highlight the intrinsic non-reciprocal response.
Differential network analysis between sex of thegenes related to comorbidities of type 2 mellitusdiabetes.
Authors: Guzzi Pietro Hiram , Cortese Francesca , Mannino Gaia Chiara , Pedace Elisabetta , Succurro Elena , Andreozzi Francesco , Pierangelo Veltri 
Published: March 2023

Abstract
Background Some phenotypical changes may be related to changes in the associations among genes. The set of such associations is referred to as gene interaction (or association) networks. An association network represent the set of association among genes in a given condition. Given two experimental conditions, Differential network analysis (DNA) algorithms analyse these differences by deriving a novel network representing the differences. Such algorithms receive as input experimental gene-expression data of two different conditions (e.g. healthy vs diseased), then they derive experimental networks of associations among genes and, finally, they analyse differences among networks using statistical approaches. We explore the possibility to study possible rewiring due to sex factors, differently from classical approaches.
Methods We apply DNA methods to evidence possible sex based differences on genes responsible for comorbidities of type 2 diabetes mellitus.
Results Our analysis evidences the presence of differential networks in tissues that may explain difference in the insurgence of comorbidities between males and females.
Conclusion Main contributions of this work are: (i) the definition of a novel framework of analysis able to shed out light on the differences betweeen males and females; (ii) the identification of differential networks related to diabetes comorbidities.
Availability and implementation: All the datasets underlying this article are publicly available. Data and source code can be accessed through the web at https://github.com/hguzzi/DifferentialNetworkDiabetes.
High Performance Fractional Anisotropic Diffusion Filter forPortable Applications
Authors: AbdAlRahman Alaa , Al-Atabany Walid I , Soltan Ahmed , Radwan Ahmed G. 
Published: March 2023

Abstract
Anisotropic diffusion is one of the most effective methods used in image processing. It can be used to eliminate the small textures of an imagewhile preserving its significant edges. In this paper,a new anisotropic diffusion filter is proposed based on a fractional calculus kernel rather than an integer kernel to improve the overall performance of the filter. Integer and fractional anisotropic filters are implementedusing the Genesys-2 FPGA kit to utilize the efficiency of parallelism in FPGAs. Integer and fractional anisotropic filters are tested against the achievable PSNR value vs the number of iterations. The proposed fractional anisotropic filter has a better PSNR value using a smaller number of iterations, reducing the power and area compared to integer anisotropic filter.The proposed filter can be used in image smoothing,edge detection, image segmentation, image denoisingand cartooning. In addition, the proposed filter will save the power of applications with power constraints, such as portable devices, as it requires fewer iterations than integer anisotropic filters. The proposed filter reduces the required power consumption by 58.2%.
Risk Factors for Recurrence after Keloid Surgery with Electron Radiotherapy
Authors: Liu Chunlei 
Published: March 2023

Abstract
Aim to investigate the local control effect of postoperative electron radiotherapy for keloid and new recurrence risk factors. We collected the clinical data of 82 patients with 129keloids from January 2015 to October 2019. There were 23 males (28%) and 59 females (72%). Median age was 32 years (18-67 years). There were 26 recurrences, and the 1-year, 3-year and 5-year local control rates were 93%, 81% and 73%, respectively. Univariate analysis showed that age (p=0.025), hypertension (p=0.035), scar shape (p<0.001), primary site (p=0.021), maximum diameter of the lesion (p<0.001), pain and itching symptoms (p=0.005), local tension (p=0.005), and infection (p<0.001) were independent influencing factors. Multivariate analysis showed that the maximum diameter (p<0.001), infection (p<0.001), interval time (p=0.023), and previous treatment (p=0.020) were independent influencing factors. Our results suggest that complete excision of keloid combined with electron radiotherapy is safe and effective, while additional triamcinolone has no significant benefit for local control. For keloids with a high risk of recurrence, more aggressive treatment should be chosen, and further prospective studies are needed to explore the optimal treatment.
Berberine-loaded lipid nanoparticle inhibits H2O2-induced chondrocyte injury by promoting mitochondria autophagy in C28/I2 cells
Authors: Yi Guoliang , Xie Peng , Meng Qingqi , Li Siming 
Published: March 2023

Abstract
Although berberine (BBR) is considered to be of therapeutic value in treating various disorders; however, its low bioavailability hinders its further development on clinical application. To evaluate the effects of BBR against chondrocyte damage, we synthesized liposomal nanoparticles loaded with BBR (BBR@LNPs) with an average particle size of 137 nm using microfluidic technology. The CCK8 assay was used to determine the cytotoxicity of the BBR@LNPs in C28/I2. Additionally, flow cytometry and western blotting were used to investigate the mechanism of its protect chondrocytes from H2O2-induced oxidative damage in C28/I2. Our findings showed that BBR@LNPs had stable nanoscale structure and low cytotoxicity. Importantly, administration of BBR@LNPs significantly inhibited ROS release and cell apoptosis in H2O2-induced C28/I2, BBR@LNPs enhanced mitochondrial autophagy by up-regulating PINK1 and Parkin expression. Our findings may provide some guidance BBR-loaded lipid nanoparticle delivery system in cartilage injury.
The Use of the Pulse Oximeter in Limb Ischaemia: the PULSE study
Authors: Skillman Joanna , Dutta Pratap , Kimani Peter K , Leaver Ian , Venus Matthew , Wallace David , Hardwicke Joseph , Imray Christopher 
Published: March 2023

Abstract
Purpose
Does a non-invasive pulse oximeter probe accurately indicate limb ischaemia with inflation of a tourniquet? How are the pulse waveform, perfusion index and oxygen saturations affected? Does pulse oximetry return to normal with restoration of blood flow? Are the findings similar, regardless of which probe is used?
Methods
Single centre, pilot, proof of concept study. Each volunteer staff member had two probes applied to both lower limbs and then to both upper limbs. One limb had a tourniquet applied (experimental limb). The pulse oximeter trace, perfusion index and oxygen saturations were recorded before tourniquet inflation (timepoint 0), at inflation (timepoint 1), just prior to deflation (timepoint 2) and after deflation when the waveform returned to a biphasic appearance (timepoint 3).
Results
Changes in both pulse oximeter waveforms occurred within 45 seconds of tourniquet inflation, with flattening of the biphasic trace followed by complete loss of amplitude which normalised on release of the tourniquet. Perfusion index values for the experimental arms and legs were statistically significantly smaller than the control sides during tourniquet inflation and exceeded baseline on deflation, due to reperfusion. Oxygen saturations were unreliable and did not reflect tourniquet inflation.
Conclusion
Pulse Oximeter waveform and perfusion index provide a noninvasive, sensitive, responsive, available, repeatable, objective measure of vascular supply in the limbs in healthy volunteers, although oxygen saturation is not a reliable indicator of perfusion. Objective assessment using the pulse oximeter could aid clinical judgement in initiating early vascular intervention in limb injury.
Impact of double shield tunnel construction on adjacent pile foundation in silty fine sand strata
Authors: Jiao Ning , Ding Jianwen , Liao Zhaosheng , Wan Xing , Gao Pengju 
Published: March 2023

Abstract
Shield tunnel construction inevitably penetrates pile foundations laterally in urban areas, resulting in surrounding ground movements and pile displacements. The engineering accidents occur when the deformation is out of limits, thus it is essential to grasp the pile deformation caused by shield tunnelling accurately. This paper presents a case study on the pile deformation caused by double shield tunnel construction in silty fine sand strata inNantong, China. The field monitoring program was con-ducted to observe pile settlement during the shield construction process. A practical method to estimate the induced pile settlement was proposed and verified. Moreover, a three-dimensional finite element model was established using Plaxis 3D software. The effects of grouting pressure, supporting pressure at excavation face, pile buried depth and other pile-tunnel geometry factors were examined. The re-sults indicated negligible differential settlements between piles and surrounding ground surface in the silty fine sand strata, which were significantly smaller than those in clay strata. The differential settlement of the piles on both sides of the tunnel reached its maximum as the shield tail of preceding tunnel passed through the pile. The supporting pressure of excavation face had most significant effect on the lateral deformation of the pile in the shield tunnelling direction. Moderate increase in the grouting pressure reduces the deformation and force of the pile effectively. The maximum settlement of the pile top was proportional to the diameter and buried depth of the tunnel, but was inversely proportional to the pile length and the horizontal distance between pile and tunnel. Furthermore, the risk status of the pile could be quickly identified by the risk level distribution map of piles, which facilitated the timely protective measures.
A Fibrin Glue Delivery System Containing rhein with anti-inflammatory efficacy to inhibit pyroptosis of nucleus pulposus cells ameliorates intervertebral disc degeneration
Authors: Bao Jianhang , Gao wenshuo , Zhang Wei , Wang Dong , Pan Hao 
Published: March 2023

Abstract
Purpose
To construct an injectable, sustained-release hydrogel containing rhein to solve the problem of low bioavailability of rhein, and observe its efficacy in the treatment of intervertebral disc degeneration.
Methods
The fibrin gel containing rhein was first synthesized in advance. Subsequently, the materials were characterized by various experimental methods. Secondly, the degenerative cell model was constructed by stimulating nucleus pulposus cells with lipopolysaccharide (LPS), and the corresponding intervention treatment was carried out to observe the effect in vitro. Finally, the rat tail intervertebral disc was acupunctured by needles to establish the intervertebral disc degeneration model, and the effect of the material was observed through intradiscal injection.
Results
The fibrin glue containing rhein (rhein@FG) showed good injectability, sustained release and biocompatibility. Rhein@FG can improve the LPS-induced inflammatory microenvironment, regulate ECM metabolic disorders of nucleus pulposus cells and aggregation of the NLRP3 inflammasome in vitro, and inhibit cell pyroptosis. Furthermore, in vivo experiments, rhein@FG effectively prevented needle puncture-induced intervertebral disc degeneration in rats.
Conclusions
Rhein@FG has better efficacy than rhein or FG alone due to its slow release and mechanical properties, which can be used as a potential replacement therapy for intervertebral disc degeneration.
Stochastic Convergence of Coal Consumption – Fresh Evidence with Sharp and Smooth breaks
Authors: Cai Yifei , Chang Yu-Cheng , Chang Tsangyao , Wang Mei-Chih 
Published: March 2023

Abstract
This study attempts to revisit the stochastic convergence of coal consumption for 39 countries through panel unit root test with both sharp and smooth breaks proposed by Bahmani-Oskooee et al. (2014). The empirical findings support convergence for 34 of 39 countries. The coal consumption for Ireland, China, South Africa, Indonesia and Vietnam is divergence. That is, shocks to coal consumption for these five countries would make permanent effects on the move path. The time-varying fitted intercepts indicate the more robust estimation of this study. The traditional unit root tests perform lower efficiency on testing the stationarity of coal consumption. Besides, not only sharp breaks should be considered in the future studies, but also smooth breaks should be also approximated. Policy conservation policy would make transitory impacts on coal consumption for converging group, but permanently affect coal consumption for diverging group. For Ireland, China, South Africa, Indonesia and Vietnam, the policy conservation policy would indirectly affect aggregate economic sectors related to consume coal energy. However, to cut the increasing trend of coal consumption, other renewable energy should further be explored. Finally, some future research directions are recommended in the end.