bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Malignancy Status Effect Outcomes in Patients With Large Vessel Occlusion Stroke and Cancer Who Underwent Endovascular Thrombectomy?
Authors: Shalabi Fatma , Sacagiu Tzvika , Honig Asaf , Molad Jeremy , Itsekson‐Hayosh Zeev , Hallevi Hen , Orion David , Aladin Shorooq , Gomori John M. , Cohen Jose E. , Leker Ronen R. 
Published: July 2023

Background
Cancer is associated with an increased risk of acute ischemic stroke, including large vessel occlusions. Whether cancer status affects outcomes in patients with large vessel occlusions that undergo endovascular thrombectomy remains unknown.

Methods and Results
All consecutive patients undergoing endovascular thrombectomy for large vessel occlusions were recruited into a prospective ongoing multicenter database, and the data were retrospectively analyzed. Patients with active cancer were compared with patients with cancer in remission. Association of cancer status with 90‐day functional outcome and mortality were calculated in multivariable analyses. We identified 154 patients with cancer and large vessel occlusions that underwent endovascular thrombectomy (mean age, 74±11; 43% men; median National Institutes of Health Stroke Scale 15). Of the included patients, 70 (46%) had a remote history of cancer or cancer in remission, and 84 (54%) had active disease. Outcome data at 90 days poststroke were available for 138 patients (90%) and was classified as favorable in 53 (38%). Patients with active cancer were younger and more often smoked but did not significantly differ from those without malignancy in other risk factors, stroke severity, stroke subtype, or procedural variables. Favorable outcome rates among patients with active cancer did not significantly differ compared with those seen in patients without active cancer, but mortality rates were significantly higher among patients with active cancer on univariate and multivariable analyses.

Conclusions
Our study suggests that endovascular thrombectomy is safe and efficacious in patients with history of malignancy as well as in those with active cancer at the time of stroke onset, although mortality rates are higher among patients with active cancer.
Tmax Mismatch Ratio to Identify Intracranial Atherosclerotic Stenosis‐Related Large‐Vessel Occlusion Before Endovascular Therapy
Authors: Yoshimoto Takeshi , Inoue Manabu , Tanaka Kanta , Koge Junpei , Shiozawa Masayuki , Kamogawa Naruhiko , Ishiyama Hiroyuki , Abe Soichiro , Imamura Hirotoshi , Kataoka Hiroharu , Koga Masatoshi , Ihara Masafumi , Toyoda Kazunori 
Published: July 2023

Background
We aimed to clarify which time‐to‐maximum of the tissue residue function (Tmax) mismatch ratio is useful in predicting anterior intracranial atherosclerotic stenosis (ICAS)–related large‐vessel occlusion (LVO) before endovascular therapy.

Methods and Results
Patients with ischemic stroke who underwent perfusion‐weighted imaging before endovascular therapy for anterior intracranial LVO were divided into those with ICAS‐related LVO and those with embolic LVO. Tmax ratios of >10 s/>8 s, >10 s/>6 s, >10 s/>4 s, >8 s/>6 s, >8 s/>4 s, and >6 s/>4 s were considered Tmax mismatch ratios. Binominal logistic regression was used to identify ICAS‐related LVO, and the adjusted odds ratio (aOR) and 95% CI for each Tmax mismatch ratio increase of 0.1 were calculated. A similar analysis was performed for ICAS‐related LVO with and without embolic sources, using embolic LVO as the reference. Of 213 patients (90 women [42.0%]; median age, 79 years), 39 (18.3%) had ICAS‐related LVO. The aOR (95% CI) per 0.1 increase in Tmax mismatch ratio in ICAS‐related LVO with embolic LVO as reference was lowest with Tmax mismatch ratio >10 s/>6 s (0.56 [0.43–0.73]). Multinomial logistic regression analysis also showed the lowest aOR (95% CI) per 0.1 increase in Tmax mismatch ratio with Tmax >10 s/>6 s (ICAS‐related LVO without embolic source: 0.60 [0.42–0.85]; ICAS‐related LVO with embolic source: 0.55 [0.38–0.79]).

Conclusions
A Tmax mismatch ratio of >10 s/>6 s was the optimal predictor of ICAS‐related LVO compared with other Tmax profiles, with or without an embolic source before endovascular therapy.

Registration

clinicaltrials.gov
. Identifier NCT02251665.
Coexistence of Metabolic Dysfunction‐Associated Fatty Liver Disease and Chronic Kidney Disease Is a More Potent Risk Factor for Ischemic Heart Disease
Authors: Miyamori Daisuke , Tanaka Marenao , Sato Tatsuya , Endo Keisuke , Mori Kazuma , Mikami Takuma , Hosaka Itaru , Hanawa Nagisa , Ohnishi Hirofumi , Furuhashi Masato 
Published: July 2023

Background
Metabolic dysfunction–associated fatty liver disease (MAFLD), defined as fatty liver with overweight/obesity, type 2 diabetes, or metabolic abnormalities, is a newly proposed disease. However, it remains unclear whether the coexistence of MAFLD and chronic kidney disease (CKD) is a more potent risk factor for ischemic heart disease (IHD).

Methods and Results
We investigated the risk of the combination of MAFLD and CKD for development of IHD during a 10‐year follow‐up period in 28 990 Japanese subjects who received annual health examinations. After exclusion of subjects without data for abdominal ultrasonography or with the presence of IHD at baseline, a total of 14 141 subjects (men/women: 9195/4946; mean age, 48 years) were recruited. During the 10‐year period (mean, 6.9 years), 479 subjects (men/women, 397/82) had new onset of IHD. Kaplan–Meier survival curves showed significant differences in rates of the cumulative incidence of IHD in subjects with and those without MAFLD (n=4581) and CKD (n=990; stages 1/2/3/4–5, 198/398/375/19). Multivariable Cox proportional hazard model analyses showed that coexistence of MAFLD and CKD, but not MAFLD or CKD alone, was an independent predictor for development of IHD after adjustment for age, sex, current smoking habit, family history of IHD, overweight/obesity, diabetes, hypertension, and dyslipidemia (hazard ratio, 1.51 [95% CI, 1.02–2.22]). The addition of the combination of MAFLD and CKD to traditional risk factors for IHD significantly improved the discriminatory capability.

Conclusions
The coexistence of MAFLD and CKD predicts new onset of IHD better than does MAFLD or CKD alone.
Frailty, Treatments, and Outcomes in Older Patients With Myocardial Infarction: A Nationwide Registry‐Based Study
Authors: Christensen Daniel Mølager , Strange Jarl Emanuel , Falkentoft Alexander Christian , El‐Chouli Mohamad , Ravn Pauline B. , Ruwald Anne Christine , Fosbøl Emil , Køber Lars , Gislason Gunnar , Sehested Thomas S. G. , Schou Morten 
Published: July 2023

Background
Guidelines recommend that patients with myocardial infarction (MI) receive equal care regardless of age. However, withholding treatment may be justified in elderly and frail patients. This study aimed to investigate trends in treatments and outcomes of older patients with MI according to frailty.

Methods and Results

All patients aged ≥75 years with first‐time MI during 2002 to 2021 were identified through Danish nationwide registries. Frailty was categorized using the Hospital Frailty Risk Score. One‐year risk and hazard ratios (HRs) for days 0 to 28 and 29 to 365 were calculated for all‐cause death. A total of 51 022 patients with MI were included (median, 82 years; 50.2% women). Intermediate/high frailty increased from 26.7% in 2002 to 2006 to 37.1% in 2017 to 2021. Use of treatment increased substantially regardless of frailty: for example, 28.1% to 48.0% (statins), 21.8% to 33.7% (dual antiplatelet therapy), and 7.6% to 28.0% (percutaneous coronary intervention) for high frailty (all
P
‐trend <0.001). One‐year death decreased for low frailty (35.1%–17.9%), intermediate frailty (49.8%–31.0%), and high frailty (62.8%–45.6%), all
P
‐trend <0.001. Age‐ and sex‐adjusted 29‐ to 365‐day HRs (2017–2021 versus 2002–2006) were 0.53 (0.48–0.59), 0.62 (0.55–0.70), and 0.62 (0.46–0.83) for low, intermediate, and high frailty, respectively (
P
‐interaction=0.23). When additionally adjusted for treatment, HRs attenuated to 0.74 (0.67–0.83), 0.83 (0.74–0.94), and 0.78 (0.58–1.05), respectively, indicating that increased use of treatment may account partially for the observed improvements.

Conclusions
Use of guideline‐based treatments and outcomes improved concomitantly in older patients with MI, irrespective of frailty. These results indicate that guideline‐based management of MI may be reasonable in the elderly and frail.
Investigation of the patients with recurrent acute transfusion reactions: A single tertiary medical centre experience
Authors: Hsieh Ming-Yun , Chen Jin-Shuen , Yin Chun-Hao 
Published: July 2023

Objective To assess the spectrum of patients who developed recurrent acute transfusion reactions (TRs) and to characterize these recurrent TRs. Methods This retrospective study included patients who developed ≥2 acute TRs between April 2017 and March 2020 in a tertiary medical centre. Results Among 216 TRs that occurred after 2024 transfusions in 87 patients, 66 (75.9%) patients reported a history of transfusions before the first TR and 70 (80.5%) patients received further transfusions after the last TR; with the same type of TR and reaction to the same type of blood product observed in 59 (67.8%) patients and 56 (64.4%) patients, respectively. TRs were most commonly associated with packed red blood cell (PRBC) transfusions and a febrile non-haemolytic transfusion reaction (FNHTR) was the most common type of TR. However, leukocyte reduced (LR) PRBCs were less common than LR platelets among transfusions with TR (22.7% [27/119] versus 75.0% [57/76], respectively) and premedication was prescribed before 196 of 216 (90.7%) transfusions with TR. Conclusion Most patients with recurrent TRs received repeated transfusions in addition to transfusions with TR. Instead of considering premedication, an increase in the use of LR might be the strategy to reduce the recurrence of TR.
Parents living with and beyond cancer: A scoping review of unmet supportive care needs and impact on daily life
Authors: Newman Robin , Kaldenberg Jennifer , Stursberg Laura , Pinto Brianna , Jimenez Christine , Glazer Kara 
Published: July 2023

Introduction: Parenting is a valued and complex role that is shaped by culture and context, which can be significantly impacted by a cancer diagnosis. This scoping review explored the unmet supportive care needs and impact on daily life for parents living with and beyond cancer. Methods: We used the PRISMA extension for scoping reviews (PRISMA-ScR) reporting guidelines to conduct a scoping review of the literature. Peer-reviewed literature published between January 2006 and December 2021 was searched using five databases: CINAHL, PsycINFO, PubMed, EMBASE, and Web of Science. Results: A total of 47 articles were included in the review representing 14 countries. Unmet supportive care needs persist across physical, spiritual, psychological, social, informational, practical, emotional domains, regardless of cancer diagnosis, stage of cancer or phase of the cancer care continuum. These unmet needs significantly impacted the daily lives of mothers and fathers living with and beyond cancer throughout studies. Conclusion: The results from this review highlight the range of reported supportive care needs of parents and its impact potentially contributing to occupational disruption. This provides a unique opportunity for occupational therapy practitioners to contribute to the occupational needs of parents living with and beyond cancer as an integral member of the interprofessional cancer care team.
Relationship between sexual quality of life and life satisfaction in women with urinary incontinence: A cross-sectional survey
Authors: Güleryüz Alime , Altay Birsen 
Published: July 2023

Purpose: This study aims to investigate the relationship between the sexual quality of life and life satisfaction in women with urinary incontinence. Methods: This research is Correlational-descriptive research. Sample of the study consisted of 210 women with urinary incontinence. The data of the study were collected using “The Patient Information Form,” “The Sexual Quality of Life Questionnaire” and “The Satisfaction with Life Scale.” In analyzing; Mann-Whitney U tests, Kruskal Wallis variance analysis were used. Results: It has been found that educational status, income status, menopause status, and frequency of urinary incontinence affect the sexual quality of life. A statistically significant positive moderate linear relationship was found between the mean SWLS scores and the mean SQOL scores ( p < 0.05). Conclusion: In this study, it was found that the sexual quality of life increased as The Life Satisfaction Of Women With Urinary Incontinence Increased.
Toxic effects of ship exhaust gas closed-loop scrubber wash water
Authors: Ji Zhiyi , Yang Yunqi , Zhu Ying , Ling Yun , Ren Dezhang , Zhang Nahui , Huo Zhibao 
Published: July 2023

To meet the strict requirements of reducing sulfur emissions, an increasing number of commercial ships have installed exhaust gas cleaning systems (EGCSs). However, wash water produced during the cleaning process is discharged back to the marine environment. We investigated the effects of closed-loop scrubber (natrium-alkali method) wash water on three trophic species . Severe toxic effects were found when Dunaliella salina, Mysidopsis bahia, and Mugilogobius chulae were exposed to 0.63–6.25, 0.63–10, and 1.25–20% concentrations of wash water, respectively. The 50% effective concentration in 96 h (EC50-96 h) for D. salina was 2.48%, and the corresponding total polycyclic aromatic hydrocarbons (PAHs) and heavy metals were 22.81 and 23.67 μg L−1. The 50% lethal concentration in 7 d (LC50-7 d) values for M. bahia and M. chulae were 3.57% and 20.50%, respectively. The lowest observed effect concentration (LOEC) values for M. bahia and M. chulae were 1.25% and 2.5%, respectively, and the corresponding total PAHs and heavy metals were 11.50 and 11.93 and 22.99 and 23.86 μg L−1. M. bahia’s body weight was negatively correlated with the amount of wash water. Low concentrations of wash water (0–5%) had no significant effect on the reproduction of M. bahia. Although concentrations of 16 PAHs and 8 heavy metals are known, different compounds might react with each other and form more unknown toxic substances, and the measured toxicity comes from synergistic effects between various pollutants. Therefore, future work is needed to clarify other more toxic contaminants in wash water. We highly recommend that wash water be treated before being discharged to the marine environment.
Water-soluble Yb3+, Er3+ codoped NaYF4 nanoparticles induced SGC-7901 cell apoptosis through mitochondrial dysfunction and ROS-mediated ER stress
Authors: Liu Chen , Sun Shaoqiang , Mao Jingwei 
Published: July 2023

Background Nanoparticles are potential luminescent probes; among them, upconversion nanoparticles (UCNP) are currently being developed as fluorescent probes for biomedical applications. However, the molecular mechanisms of UCNP in human gastric cell lines remain poorly understood. Here, we aimed to examine UCNP cytotoxicity to SGC-7901 cells and explore its underlying mechanisms. Methods The effects of 50–400 μg/mL UCNP on human gastric adenocarcinoma (SGC-7901) cells were investigated. Flow cytometry was used to evaluate reactive oxygen species (ROS), mitochondrial membrane potential (ΔΨm), intracellular Ca2+ levels, and apoptosis. Activated caspase-3 and nine activities were measured; meanwhile, cytochrome C (Cyt C) in the cytosol and B-cell lymphoma 2 (Bcl-2), Bcl-2 associated X protein (Bax), protein kinase B (Akt), phosphorylated-Akt (p-Akt), 78 kDa glucose-regulated protein (GRP78), 94 kDa glucose-regulated protein (GRP94), calpain-1, and calpain-2 protein levels were also detected. Results UCNP inhibited the viability of SGC-7901 cells in a concentration- and time-dependent manner and increased the proportion of cell apoptosis. Exposure to UCNP enhanced the ratio of Bax/Bcl-2, elevated the level of ROS, decreased ΔΨm, increased intracellular Ca2+ and Cyt C protein levels, decreased the levels of phosphorylated Akt, increased the activity of caspase-3 and caspase-9, and upregulated the protein expression of GRP-78, GRP-94, calpain-1 and calpain-2 in SGC-7901 cells. Conclusion UCNP induced SGC-7901 cell apoptosis by promoting mitochondrial dysfunction and ROS-mediated endoplasmic reticulum (ER) stress, initiating the caspase-9/caspase-3 cascade.
Diagnostic Value of Inflammation-Related Indicators in Distinguishing Early Colon Cancer and Adenomatous Polyps
Authors: Feng Zhewen , Lin Huajun , Yang Xiaobao , Cao Shun , Gu Xiaozhe , Zhang Zhongtao , Deng Wei 
Published: July 2023

Background There are few clinical symptoms in early colorectal cancer, so it is necessary to find a simple and economical tumor detection index for auxiliary diagnosis. This study aims to explore the diagnostic value of preoperative inflammation-related indicators, such as neutrophil, lymphocyte, platelet count, platelet to lymphocyte ratio (PLA), neutrophil to lymphocyte ratio (NLR), and systemic immune-inflammation index (SII), for early colorectal cancer, and determine whether inflammation-related indicators can provide more accurate diagnostic judgment for patients. Methods This study was a retrospective study. Patients who were first diagnosed with colorectal cancer or colorectal adenomatous polyp at Beijing Friendship Hospital from October 2016 to October 2017 were retrospectively collected. According to inclusion and exclusion criteria, a total of 342 patients were included, including 216 patients with colorectal cancer and 126 patients with colorectal adenomatous polyp. Fasting venous blood and other clinical features were collected to compare the differences between colorectal cancer and colorectal adenoma. Results There were statistically significant differences in age, carcinoembryonic antigen, albumin, hemoglobin, mean platelet volume, lymphocyte, monocyte, NLR, PLA, SII, and mean platelet volume to platelet count ratio between colorectal cancer group and colorectal adenoma group ( P < .05), and a Nomogram model was established. Using inflammatory markers to differentiate colorectal and colorectal polyps produced greater AUC than using tumor markers alone (.846 vs .695). Conclusion Inflammation-related indicators, such as lymphocyte, monocyte, and mean platelet volume, may serve as potential indicators to assist in the diagnosis of early colorectal cancer.
Implementing an APRN-Led Integrated Behavioral Health Clinic in a Rural Community
Authors: Cook Leigh K. , Burge Stephanie A. , Mathews Therese L. , Kupzyk Kevin A. , Houfek Julia F. 
Published: July 2023

OBJECTIVE: A rural primary care clinic implemented an advance practice providers, including nurse practitioner (APRN)-led integrated behavioral health program to facilitate holistic health care delivery. METHODS: Implementation was facilitated by Health Resources and Services Administration Grant funding to a state University College of Nursing. The College formed an academic-practice partnership with a Federally Qualified Health Center (FQHC) to implement integrated care in a rural satellite clinic administered by the FQHC. An interdisciplinary team (two family APRNs, a psychiatric APRN, a licensed behavioral health provider, and the Grant Project Director who is a Psychiatric APRN and a licensed Psychologist) provided the integrated care based on the University of Washington’s Collaborative Care Model. RESULTS: This brief report describes the implementation of integrated care during the clinic’s first year, services provided, lessons learned, community response, and improvement in anxiety and depressive symptoms for patients who were treated for behavioral health problems. An exemplar illustrates how collaborative care addressed one patient’s behavioral health and primary care needs. CONCLUSIONS: APRN-led collaborative care can expand access to holistic, affordable care in rural areas to improve mental health. Adaptation and flexibility in traditional roles may be necessary and determining post-grant access to funding for services will be necessary for sustainability.
Patterns of equipment use for autistic children in multi-sensory environments: Time spent with sensory equipment varies by sensory profile and intellectual ability
Authors: Unwin Katy L , Powell Georgina , Price Alice , Jones Catherine RG 
Published: July 2023

Multi-sensory environments are widely used with autistic children. However, there are no data on how autistic children choose to spend time in the room and how this relates to their sensory, behavioural and intellectual profiles. We observed the frequency and duration of visits to multi-sensory environment equipment of 41 autistic children during 5 min of free play. At a group level, the bubble tube and touch, sound and light board were both highly popular, with the fibre optics and tactile board receiving less attention. Sensory seeking behaviours were more commonly observed in the multi-sensory environment than sensory-defensive behaviours. We found that observed sensory seeking behaviours, along with parent-reported sensory behaviours and non-verbal intelligence quotient, were associated with specific patterns of multi-sensory environment equipment use, but broader autistic behaviours were not. These data suggest that the multi-sensory environment equipment preferences of autistic children are related to individual differences in sensory behaviour and non-verbal intelligence quotient. This information has the potential to inform the development of best-practice multi-sensory environment guidelines that focus on individual needs. Lay abstract Multi-sensory environments, often called sensory rooms, are widely used with autistic children. However, we know very little about how autistic children choose to spend their time in multi-sensory environments. We also do not know how their equipment preferences relate to their individual characteristics such as their sensory differences, level of ability or general autistic behaviours. We measured the frequency and duration of visits to multi-sensory environment equipment of 41 autistic children during 5 min of free play. The bubble tube and touch, sound and light board were both highly popular, with the fibre optics and tactile board receiving less attention. The children displayed significantly more sensory seeking behaviours in the multi-sensory environment than sensory-defensive behaviours. These sensory seeking behaviours, as well as the sensory behaviours that their parents reported they showed in daily life, were associated with specific patterns of multi-sensory environment equipment use. Non-verbal ability was also associated with multi-sensory environment equipment use, but broader autistic behaviours were not. Our findings show that the multi-sensory environment equipment preferences of autistic children are related to individual differences in sensory behaviours and non-verbal ability. This information could be useful for teachers and other practitioners who want to know how best to use multi-sensory environments with autistic children.
A new general method for assigning frequencies with low spillover through structural modifications
Authors: Liu Zihao , Pang Jichao , Ouyang Huajiang , Xie Guocheng 
Published: July 2023

By modifying the mass and stiffness parameters of a structure, a subset of its natural frequencies can be assigned. However, such an assignment is usually accompanied with changes of the remaining frequencies, known as ‘spillover’. Eigenvalue or frequency spillover often needs to be avoided in engineering. In this paper, a new and general method is proposed for assigning a subset of the natural frequencies of a structure with a low level of spillover through structural modifications. The method combines a multi-population genetic algorithm and a radial basis function neural network and is implemented in a MATLAB-PYTHON-ABAQUS data interaction system. It is suitable for theoretical models (for example, finite element models) of general structures. By means of three numerical examples, the ability of the method to assign subsets of frequencies to discrete and discretised continuous structures while maintaining low spillover is demonstrated.