bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iron‐Porphyrin‐Based Covalent Assembly with Peroxidase‐Like Activity and High Efficiency for Cr(VI) Colorimetric Detection
Authors: Xu Hanxin , Li Mengxue , Zang Mingsong , Sun Jianxin , Jia Dan , Hou Chunxi , Liu Junqiu 
Published: January 2023

AbstractEfficient synthesis of functional nanomaterials for simple, sensitive, and accurate colorimetric detection of chromate [Cr(VI)] has attracted great interest due to the toxicity of Cr(VI). Here, novel covalently assembled iron porphyrins (CAIPs) are fabricated through covalently cross‐linking reaction between iron‐tetra‐(4‐hydroxy‐phenyl) porphyrin and three different cross‐linkers based on 3,3´‐dithiodipropionic acid. The results show that CAIPs have a spherical vesicle framework with favorable dimensional structure and enzymatic activity. In the presence of H2O2, CAIPs exhibit high peroxidase‐like activity toward 3,3´,5,5´‐tetramethylbenzidine. Based on these findings, CAIPs are used as an efficient colorimetric catalyst for the sensitive and selective detection of Cr(VI) with a detection limit about 23 nm. The feasibility of this method for real‐water samples is verified by a standard addition experiment. This system further facilitates the developments of nanomaterial, and its application in colorimetric detection fields.
Design of Hygroscopic Bioplastic Products Stable in Varying Humidities
Authors: Liu Sirui , Bettelli Mercedes A. , Wei Xinfeng , Capezza Antonio J. , Sochor Benedikt , Nilsson Fritjof , Olsson Richard T. , Johansson Eva , Roth Stephan V. , Hedenqvist Mikael S. 
Published: January 2023

AbstractHygroscopic biopolymers like proteins and polysaccharides suffer from humidity‐dependent mechanical properties. Because humidity can vary significantly over the year, or even within a day, these polymers will not generally have stable properties during their lifetimes. On wheat gluten, a model highly hygroscopic biopolymer material, it is observed that larger/thicker samples can be significantly more mechanically stable than thinner samples. It is shown here that this is due to slow water diffusion, which, in turn, is due to the rigid polymer structure caused by the double‐bond character of the peptide bond, the many bulky peptide side groups, and the hydrogen bond network. More than a year is required to reach complete moisture saturation (≈10 wt.%) in a 1 cm thick plate of glycerol‐plasticized wheat gluten, whereas this process takes only one day for a 0.5 mm thick plate. The overall moisture uptake is also retarded by swelling‐induced mechanical effects. Hence, hygroscopic biopolymers are better suited for larger/thicker products, where the moisture‐induced changes in mechanical properties are smeared out over time, to the extent that the product remains sufficiently tough over climate changes, for example, throughout the course of a year.
A new role for monomeric ParA/Soj in chromosome dynamics in Bacillus subtilis
Authors: Roberts David M. 
Published: January 2023

AbstractParABS (Soj‐Spo0J) systems were initially implicated in plasmid and chromosome segregation in bacteria. However, it is now increasingly understood that they play multiple roles in cell cycle events in Bacillus subtilis, and possibly other bacteria. In a recent study, monomeric forms of ParA/Soj have been implicated in regulating aspects of chromosome dynamics during B. subtilis sporulation. In this commentary, I will discuss the known roles of ParABS systems, explore why sporulation is a valuable model for studying these proteins, and the new insights into the role of monomeric ParA/Soj. Finally, I will touch upon some of the future work that remains.
Effective Subthalamic Nucleus Deep Brain Stimulation Following MRgFUS for Tremor Dominant Parkinson's Disease
Authors: Maamary Joel , Peters James , Kyle Kain , Barnett Yael , Jonker Benjamin , Tisch Stephen 
Published: January 2023

AbstractBackgroundWhilst MRI guided Focused Ultrasound (MRgFUS) thalamotomy is an effective treatment option for tremor disorders, there are reports of tremor recurrence in patients with tremor dominant Parkinson's disease (PD). The mechanisms for tremor recurrence are unknown but likely relate to the duality of tremor network pathways with ramifications for subsequent treatment options.CasesWe report two cases of tremor dominant PD who experienced tremor recurrence following MRgFUS thalamotomy with subsequent successful subthalamic nucleus deep brain stimulation (DBS). Tremor scores were measured at baseline, 1‐ and 3‐months post MRgFUS and at least 18 months post DBS in both patients. Both cases evidenced immediate improvement in tremor, after MRgFUS, followed by subsequent tremor recurrence. STN DBS resulted in almost complete long‐term tremor alleviation in both cases.ConclusionsThese cases demonstrate the efficacy and feasibility of STN DBS in patients with tremor dominant PD with tremor recurrence following MRgFUS thalamotomy. We discuss the dualism of tremor outflow pathways that may have implications for single target lesional therapies.
Who Ever Said It Would Be Easy? Reflecting on Two Clinical Trials Targeting α‐Synuclein
Authors: Jensen Poul Henning , Schlossmacher Michael G. , Stefanis Leonidas 
Published: January 2023

AbstractTwo recent, high‐profile manuscripts reported negative results with two parallel approaches of passive immunization targeting α‐synuclein in a population of patients with early Parkinson's disease (PD). These phase II studies failed to show a bona fide disease‐modifying neuroprotective effect on PD progression, despite the evidence that these antibodies effectively bind native α‐synuclein in human serum. Here, we discuss the possible reasons that could help explain the lack of clinical efficacy. In particular, we highlight (1) the wealth of evidence supporting the notion of α‐synuclein as a valid therapeutic target; (2) the lack of evidence of target engagement in the aforementioned studies, especially of the elusive oligomeric species, the likely culprits in disease pathogenesis and/or its propagation; (3) the limitations, especially in terms of timing passive immunization, of preclinical models, where the same α‐synuclein antibodies succeeded in mitigating disease manifestations; (4) the consideration of possibly intervening at an even earlier stage of disease in future trials; and (5) the multitude of strategies beyond passive immunization that could be used to combat α‐synuclein‐mediated neurodegeneration, if in the end the current approach is not fruitful. Overall, our perception is that converging developments in the field, among them novel bioassays and biomarkers, improved cellular and animal models and objective measurements of motor activities integrated into clinical trials, if further optimized, will gradually move the momentum of the field forward. This, to better test the concept of whether α‐synuclein‐targeting therapies can indeed deliver the ”holy grail” of neuroprotection to the benefit of the PD community. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Design of wideband circularly polarized metasurface antenna using characteristic mode analysis
Authors: Ding Zhendong , Xu Mengnan , Li Xiang , Tao Shifei , Wang Hao , Wang Yan 
Published: January 2023

AbstractA wideband circularly polarized metasurface antenna using characteristic mode analysis is presented in this letter, which is composed of two‐layer substrate, 4 × 4 circular patch metasurface, L‐slot, transmission line, and air spacing. Through mode analysis, the metasurface structure can significantly enhance the bandwidth and gain of the antenna, and realize circular polarization (CP). After excitation, the air spacing and the L‐slot can realize 90° difference between the characteristic angles of the two modes of the metasurface, and finally radiate CP. The measurement results show that the prototype has a −10 dB impedance bandwidth from 5.6 to 8.2 GHz (37.7%), a 3‐dB axial ratio bandwidth from 6.2 to 7.8 GHz (22.9%), and a peak gain of 8.7 dBi at 6.4 GHz.
A comparison of associations of body mass index and dual‐energy x‐ray absorptiometry measured percentage fat and total fat with global serum metabolites in young women
Authors: Dorgan Joanne F. , Ryan Alice S. , LeBlanc Erin S. , Van Horn Linda , Magder Laurence S. , Snetselaar Linda G. , Zhang Yuji , Dallal Cher M. , Jung Seungyoun , Shepherd John A. 
Published: January 2023

AbstractObjectiveBody mass index (BMI) does not directly measure adiposity, whereas dual‐energy x‐ray absorptiometry (DXA) provides valid direct estimates of adiposity. Therefore, this study evaluated usefulness of BMI as a measure of adiposity in serum metabolomics studies.MethodsA cross‐sectional analysis was conducted of 202 women aged 25 to 29 years in the Dietary Intervention Study in Children Follow‐Up Study. Heights and weights were measured, and body composition was quantified using clinical DXA protocols. Serum metabolomic profiling was performed by liquid chromatography–tandem mass spectrometry. Partial correlations of BMI, percentage fat (%FAT), and total fat (TOTFAT) with log transformed serum metabolites were calculated.ResultsThere was significant overlap in the 93 metabolites that correlated with BMI, %FAT, and/or TOTFAT; 9 differently correlated with BMI and %FAT, whereas 15 differently correlated with BMI and TOTFAT. Even for these metabolites, absolute differences were modest. Metabolite set enrichment analysis identified diacylglycerol and sphingolipid metabolism as overrepresented among metabolites significantly correlated with all three measures of adiposity.ConclusionsBMI can be a good proxy for DXA measured %FAT and TOTFAT in descriptive metabolomic studies of healthy, young White women. Larger studies in more diverse populations are needed to endorse more generalized conclusions.
Effects of microstructures of liquid polyisoprene on the properties of styrene–butadiene rubber/butadiene rubber compounds
Authors: Wang Qian , Sun Tao , Qiao Yunhe , Liu Heng , Zhang Chunyu , Zhang Xuequan , Sun Yu 
Published: January 2023

AbstractRecently, there has been an increasing interest in liquid rubbers (LRs), which can work as reactive processing aids to replace conventional plasticizers and are used as prepolymers to synthesize novel block copolymers. However, the understanding of effects of their microstructures on the properties of materials is still not sufficient. In this study, liquid 1,4‐polyisoprene (L1,4‐IR) and liquid 3,4‐polyisoprene (L3,4‐IR) with similar molecular weight were selected and mixed with styrene–butadiene rubber (SBR)/butadiene rubber (BR). The effects of microstructures of the LRs on the properties of materials were investigated. L1,4‐IR has more 1,4‐units and fewer 3,4‐units than L3,4‐IR. This gives L1,4‐IR a lower glass transition temperature and much more flexible polymer chains. Vulcanizates containing L1,4‐IR had advantages over samples containing L3,4‐IR, including lower Mooney viscosities, smaller ΔG′ value from 0.3% to 43% of strain, fewer sol fractions, better abrasion resistance and lower values of tan δ at 60 °C. In contrast, high contents of 3,4‐units endow L3,4‐IR with low unsaturation in polymer backbones and high glass transition temperature. Samples containing L3,4‐IR showed higher values of tan δ at 0 °C, better thermal stabilities and excellent DIN abrasion resistance after aging compared to samples with L1,4‐IR. Furthermore, there were no big differences in the mechanical properties of SBR/BR compounds containing L1,4‐IR or L3,4‐IR. The results of this study are of great importance to the practical application of liquid polyisoprene in the rubber industry. © 2023 Society of Industrial Chemistry.
Chlamydomonas reinhardtii mutants deficient for Old Yellow Enzyme 3 exhibit increased photooxidative stress
Authors: Böhmer Stefanie , Marx Christina , Goss Reimund , Gilbert Matthias , Sasso Severin , Happe Thomas , Hemschemeier Anja 
Published: January 2023

AbstractOld Yellow Enzymes (OYEs) are flavin‐containing ene‐reductases that have been intensely studied with regard to their biotechnological potential for sustainable chemical syntheses. OYE‐encoding genes are found throughout the domains of life, but their physiological role is mostly unknown, one reason for this being the promiscuity of most ene‐reductases studied to date. The unicellular green alga Chlamydomonas reinhardtii possesses four genes coding for OYEs, three of which we have analyzed biochemically before. Ene‐reductase CrOYE3 stood out in that it showed an unusually narrow substrate scope and converted N‐methylmaleimide (NMI) with high rates. This was recapitulated in a C. reinhardtii croye3 mutant that, in contrast to the wild type, hardly degraded externally added NMI. Here we show that CrOYE3‐mediated NMI conversion depends on electrons generated photosynthetically by photosystem II (PSII) and that the croye3 mutant exhibits slightly decreased photochemical quenching in high light. Non‐photochemical quenching is strongly impaired in this mutant, and it shows enhanced oxidative stress. The phenotypes of the mutant suggest that C. reinhardtii CrOYE3 is involved in the protection against photooxidative stress, possibly by converting reactive carbonyl species derived from lipid peroxides or maleimides from tetrapyrrole degradation.
Synthesis, crystal structure, photoisomerization, and DFT studies of novel azo compounds based on imidazole
Authors: Slassi Siham , Aarjane Mohammed , El‐Ghayoury Abdelkrim , Allain Magali , Amine Amina 
Published: January 2023

AbstractNew azo imidazole compounds 1‐3 were synthesized by condensation of 2‐hydroxy‐3‐methoxy‐5‐([aryl]diazenyl)benzaldehyde derivatives with o‐vanillin and characterized. The crystal structure of 1 crystallizes in the monoclinic system with space group P21/c and adopts an E configuration for the azo and azomethine double bonds. The photoisomerization experiments have been performed in DMSO as a function of time in order to investigate the photodynamical trans‐cis‐trans conversion of the azo (–N=N‐) chromophore of the imidazoles 1‐3. The compounds exhibited strong photoisomerization in solution and their trans to cis isomerization took about 40 min whereas the reverse process took 120 min. The experimental studies are rationalized with theoretical DFT and TD‐DFT studies successfully.
The missing piece: Effect of dangling chains on the synthesis and properties of bio‐based waterborne polyurethane
Authors: Wang Li , Luo Haihang , Gao Qiang , Jiang Le , Wang Zhenya , Fan Haojun , Chen Yi , Yan Jun , Xiang Jun 
Published: January 2023

AbstractBio‐based polyols derived from vegetable oils generally contain the dangling chains, which have recently attracted significant attention due to their influence on the preparation and performance of the waterborne polyurethane. Herein, a novel undecylenic‐based primary glycol (UPG) without dangling chains synthesized and the oleic‐based primary glycol (OPG) with dangling chains reported by our previous work were used to prepare straight‐chain and dangling‐chain bio‐based waterborne polyurethane (BWPU), respectively, to study the difference between the two diols and the effects of dangling chains on the synthesis and performance of BWPU. First, the UPG without dangling chains displayed higher activation energy (Ea/Eo = 77.72/80.56 kJ mol−1) and longer reaction end point of prepolymer (240 min), indicating relatively lower reactivity to isocyanate. In addition, the dangling chains were found to influence the dispersion stability of BWPU, and the minimum dosage of DMPA for maintaining dispersion stability was 6.5 wt% for OPG but 5.5 wt% for UPG. The average particle size of BWPU is greater for OPG than for UPG with the same DMPA content. Finally, performance studies revealed that dangling‐chain BWPU showed higher hydrophobicity, extensibility, and low temperature resistance, but lower thermal stability (Td5%) and tensile strength. This work comprehensively clarified the effects of linear and branched bio‐based polyols on the synthesis and properties of BWPU, and provided guidance for the development and application of bio‐based polyols and BWPU coatings.
The growth of process safety practice in China
Authors: Meng Yifei , Hu Yeyao , Li Weidong , Liu Yi , Zhao Dongfeng , Willey Ronald J. 
Published: January 2023

AbstractImplementation of modern process safety practices came to China around the turn of the millennium. Compared to other developed countries. It is a relatively late start. However, within a period of 20 short years, remarkable results have been achieved under the joint efforts of many parties. Firstly, this paper introduces four major contributors that influence the development of process safety in China. These are the Chinese government, industry associations and consulting companies, production enterprises, and research institutes and universities. Among them, the government guides the development of process safety in China through policy guidance and the establishment of government projects. It also provides the driving force for research. Secondly, this paper reviews the main process for the development of process safety in China. It divides the development of process safety in China into three stages: namely sporadic contact, active cooperation, and comprehensive development, according to the frequency and leading party of process safety practice activities. Finally, a systematic review of China's process safety practices is conducted from four aspects: international communication and cooperation, process safety technology promotion, safety management system promotion, and personnel training promotion.
Front Cover Image
Authors: Yang Zhao‐Kai , Qu Cheng , Pan Shi‐Xiang , Liu Yan , Shi Zhuo , Luo Chen , Qin Yao‐Guo , Yang Xin‐Ling 
Published: January 2023

The cover image is based on the Research Article Aphid‐repellent, ladybug‐attraction activities, and binding mechanism of methyl salicylate derivatives containing geraniol moiety by Zhao‐Kai Yang et al., https://doi.org/10.1002/ps.7245.image
Cell state‐directed therapy – epigenetic modulation of gene transcription demonstrated with a quantitative systems pharmacology model of temozolomide
Authors: Saini Anshul , Ballesta Annabelle , Gallo James M. 
Published: January 2023

AbstractCancer therapy continues to be plagued by modest therapeutic advances. This is particularly evident in glioblastoma multiforme (GBM) wherein treatment failures are attributed to intratumoral heterogeneity (ITH), a dynamic process of cell state transitions or plasticity. To address ITH, we introduce the concept of cell state‐directed (CSD) therapy through a quantitative systems pharmacology model of temozolomide (TMZ), a cornerstone of GBM drug therapy. The model consisting of multiple modules incorporated an epigenetic‐based gene transcription‐translation module that enabled CSD therapy. Numerous model simulations were conducted to demonstrate the potential impact of CSD therapy on TMZ activity. The simulations included those based on global sensitivity analyses to identify fragile nodes – MDM2 and XIAP – in the network, and also how an epigenetic modifier (birabresib) could overcome a mechanism of TMZ resistance. The positive results of CSD therapy on TMZ activity supports continued efforts to develop CSD therapy as a new anticancer approach.
Characterization of exhaustion disorder and identification of outcomes that matter to patients: Qualitative content analysis of a Swedish national online survey
Authors: Lindsäter Elin , Svärdman Frank , Rosquist Patrik , Wallert John , Ivanova Ekaterina , Lekander Mats , Söderholm Anna , Rück Christian 
Published: January 2023

AbstractFatigue is a common presenting problem in healthcare settings, often attributed to chronic psychosocial stress. Understanding of fatigue and development of evidence‐based treatments is hampered by a lack of consensus regarding diagnostic definitions and outcomes to be measured in clinical trials. This study aimed to map outcome domains of importance to the Swedish diagnosis stress‐induced exhaustion disorder (ED; ICD‐10, code F43.8 A). An online survey was distributed nationwide in Sweden to individuals who reported to have been diagnosed with ED and to healthcare professionals working with ED patients. To identify outcome domains, participants replied anonymously to four open‐ended questions about symptoms and expectations for ED‐treatment. Qualitative content analysis was conducted of a randomized subsample of respondents, using a mathematical model to determine data saturation. Six hundred seventy participants (573 with reported ED, 97 healthcare professionals) completed the survey. Qualitative content analysis of answers supplied by 105 randomized participants identified 87 outcomes of importance to ED encompassing physical, cognitive, and emotional symptoms as well as functional disability. Self‐rating scales indicated that many ED participants, beyond reporting fatigue, also reported symptoms of moderate to severe depression, anxiety, insomnia, poor self‐rated health, and sickness behavior. This study presents a map of outcome domains of importance for ED. Results shed light on the panorama of issues that individuals with ED deal with and can be used as a step to further understand the condition and to reach consensus regarding outcome domains to measure in clinical trials of chronic stress and fatigue. Preregistration: Open Science Framework (osf.io) with DOI https://doi.org/10.17605/OSF.IO/4VUAG
Titanium‐Based Nanoarchitectures for Sonodynamic Therapy‐Involved Multimodal Treatments
Authors: Maleki Aziz , Seyedhamzeh Mohammad , Yuan Meng , Agarwal Tarun , Sharifi Ibrahim , Mohammadi Abbas , Kelicen‐Uğur Pelin , Hamidi Mehrdad , Malaki Massoud , Al Kheraif Abdulaziz A. , Cheng Ziyong , Lin Jun 
Published: January 2023

AbstractSonodynamic therapy (SDT) has considerably revolutionized the healthcare sector as a viable noninvasive therapeutic procedure. It employs a combination of low‐intensity ultrasound and chemical entities, known as a sonosensitizer, to produce cytotoxic reactive oxygen species (ROS) for cancer and antimicrobial therapies. With nanotechnology, several unique nanoplatforms are introduced as a sonosensitizers, including, titanium‐based nanomaterials, thanks to their high biocompatibility, catalytic efficiency, and customizable physicochemical features. Additionally, developing titanium‐based sonosensitizers facilitates the integration of SDT with other treatment modalities (for example, chemotherapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, and immunotherapy), hence increasing overall therapeutic results. This review summarizes the most recent developments in cancer therapy and tissue engineering using titanium nanoplatforms mediated SDT. The synthesis strategies and biosafety aspects of Titanium‐based nanoplatforms for SDT are also discussed. Finally, various challenges and prospects for its further development and potential clinical translation are highlighted.