bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ki67 and the apparent diffusion coefficient in postoperative prostate cancer with endocrine therapy
Authors: He Jun , Che Bangwei , Li Po , Li Wei , Huang Tao , Chen Peng , Liu Miao , Li Guangyu , Zhong Siwen , Tang Kaifa 
Published: April 2023

BackgroundProstate-specific antigen (PSA) is a critical part of prostate cancer (PCa) screening, diagnosis, staging, and prognosis. However, elevated PSA levels can also be caused by several external factors. To improve the specificity and sensitivity of PSA in clinical practice, we explored whether markers or parameters may be used as prognostic targets for PCa by long-term follow-up.MethodsA total of 121 PCa patients who underwent laparoscopic radical prostatectomy (LRP) were included in our study, all of whom underwent imaging and preoperative pathological diagnosis. Endocrine therapy has long been applied to treat postoperative patients. The prognosis of enrolled patients was followed, and statistics were collected. Spearman's correlation analysis was applied to examine the relationship and clinical parameters. Kaplan–Meier analysis was used to process the clinical variables of PCa patients. Cox proportional hazards regression analysis was applied to examine univariate and multivariate variables.ResultsThe Gleason score (GS), PSA, clinical stage, nerve infiltration, organ confinement, Ki67 and apparent diffusion coefficient (ADC) were significantly associated with prognosis (all P &lt; 0.05). The GS, PSA, clinical stage, organ confined, Ki67, nerve infiltration and ADC were included in the multivariate analysis (all P &lt; 0.05). Ultimately, Ki67 and the ADC were found to provide meaningful predictive information (both P &lt; 0.05).ConclusionsKi67 and the ADC may be clinically and analytically valid prognostic biomarkers and imaging parameters in PCa. They may be useful for predicting the prognosis and risk of PCa patients undergoing postoperative routine endocrine therapy.
Generalized Solutions of Ordinary Differential Equations Related to the Chebyshev Polynomial of the Second Kind
Authors: Thongthai Waritsara , Nonlaopon Kamsing , Orankitjaroen Somsak , Li Chenkuan 
Published: April 2023

In this work, we employed the Laplace transform of right-sided distributions in conjunction with the power series method to obtain distributional solutions to the modified Bessel equation and its related equation, whose coefficients contain the parameters ν and γ. We demonstrated that the solutions can be expressed as finite linear combinations of the Dirac delta function and its derivatives, with the specific form depending on the values of ν and γ.
EKSPLORASI POTENSI FAUNA DI KAWASAN SUNGAI CIPUNAGARA KABUPATEN SUBANG SEBAGAI REKOMENDASI PENGEMBANGAN KAWASAN KONSERVASI
Authors: Yani Agus 
Published: April 2023

The variety of fauna is one of the certain natural wealth of Indonesia. Yet human characterisic to destroy forest has inflicted a loss. Therefore the fauna in its real habitat needs more attention so it may become a media in conserving the fauna and the habitat in order to save it for the future generation. The object of research is help to preserve the existing fauna and conservation area. The method of research by transect path and interviewing people around Wildlife Reserve of Cipunagar River, the observation on the location was done by following direction and position of transect diameter slowly and at the same time making note of any fauna species found. The result of the research that was done in wildlife resrve of Cipunagara River showed that there were 12 species of 8 families, are Panthera tigris sondaicus, Panthera pardus melas, Nisaetus bartelsi, Pteropus vampyrus, Trachypithecus auratus, Presbytis comate, Hystrix javanica, Sus verrucosus, Macaca fascicularis, Gallus gallus, and Colluricincla sp. The recommendation of fauna potential and conservation area is Taman Hutan Raya.
Desarrollo de la creatividad
Authors: Mírez Tarrillo de Delgado Perpetua del Socorro , Moreno Muro Juan Pablo 
Published: April 2023

El objetivo del estudio es analizar el estado del arte del desarrollo de la creatividad en preescolares de cinco años. Para ello, se aplicó una investigación de carácter cualitativo, con método hermenéutico y de tipo documental. Se seleccionaron y analizaron 17 artículos científicos relacionados con el tema desarrollado en las bases de datos de Scopus, Scielo, Dialnet, Redalyc, Latindex y Google Académico. Se concluye que, es posible desarrollar la creatividad de los niños de cinco años propiciando actividades retadoras y de interés del estudiante, siendo una de ellas la gimnasia cerebral.
Seebeck-induced anomalous Nernst effect in van der Waals MnBi2Te4 layers
Authors: Morishima Yume , Yamaguchi Naoya , Sawahata Hikaru , Ishii Fumiyuki 
Published: April 2023

Abstract
Magnetic semiconductors with an anomalous Hall conductivity σ

xy
≠ 0 near the Fermi energy are expected to have a large anomalous Nernst coefficient N owing to the Seebeck term, which is the product of the Hall angle ratio and Seebeck coefficient. In this study, we examined the typical cases of ∣N∣ ≥ 20 μV K–1 in the ferrimagnetic phase of semiconducting van der Waals layers MnBi2Te4 using first-principles calculations. A large enhancement in ∣N∣ was obtained by the Seebeck term for a wide range of carrier concentrations. The present results motivate further studies on the anomalous Nernst effect in intrinsically or doped magnetic semiconductors.
Suspension η for β bundles in ±1 geodesics in g≥1 genus creations for loops for a Topological String Theory Formalism
Authors: Bhattacharjee Deep , Samal Priyanka , Bose Pradipta Narayan , Behera Ashis Kumar , Das Saptashaw 
Published: April 2023

<p>Representing the β bundles as an infinite fibre that when acts on the geometries been presented as -1 for hyperbolic or saddle curvature and +1 for elliptic or positive curvature with ±1 for both types of curvatures with the exception of 0 curvature Euclidean geometry can cause deformation or suspension η in the complex topological space T^* thereby creating genus g≥1 or with the R_∩ formalism making the entire manifold M in the form of a suspended disc ∑D_Λ to collapse as a ring M_R for non–intersection of infinite loops ∮_∞γ as the trivial assumptions for the extreme degrees of freedom.</p>
Spatial dependency on flexibility value considering stacked transformer overload cost
Authors: Thorvaldsen Kasper Emil , Nessa Stian , Sandell Susanne , Sæle Hanne 
Published: April 2023

<p>Distribution grids in industrial areas are under pressure to increase the utilization of the existing grid and to build more grid due to electrification of existing industries and new power-intensive industries. Distribution system operators (DSOs) are currently considering if and how they can use power system flexibility, such as demand response, to simultaneously avoid overloading their grid assets and avoid investing in new grid. The DSO may choose to operate an asset, such as a transformer, beyond its rated load. However, this accelerates the aging of the transformer, hence decreasing its remaining life. In this work, a methodology is developed which relates the cost of transformer overload to the value of power system flexibility, to determine the DSO’s willingness to pay for a flexibility service. The methodology finds the spatial dependency of a flexibility services’ value by optimizing load shedding in the grid to minimize transformer loss of life (LoL). The methodology is demonstrated in a case study using real grid and load data measured in an industrial area in Norway that includes both medium voltage (MV) and low voltage (LV) transformers.</p>
Enabling Intelligent Omni-Surfaces in the Polarization Domain: Principles, Implementation and Applications
Authors: Palomares-Caballero Ángel , Molero Jiménez Carlos , Ghadi Farshad Rostami , López-Martínez F. Javier , Padilla Pablo , Morales-Jimenez David , Valenzuela-Valdés Juan 
Published: April 2023

<p>Wireless communications based on reconfigurable intelligent surfaces (RIS) have upsurged as a key research topic in the communication-theoretic arena. Recently, the RIS concept has evolved into the so-called simultaneously transmitting and reflecting intelligent omni-surfaces (STAR-IOS, or simply IOS), which extend the RIS functionality by incorporating transmission (in addition to reflection) capabilities. To realize STAR-IOS, full and independent reconfiguration capabilities for both reflected and transmitted waves are crucially required.</p>
<p>However, such full independent reconfiguration has thus far been hurdled by the intimate coupling between the transmission and reflection behaviour of the IOS elements. To overcome this challenge and realize the full potential of reconfigurable IOS-aided systems, we here advocate for the use of the polarization domain in the design and operation of STAR-IOS. Thanks to the polarization-dependent features of IOS elements, fully independent (reconfigurable) transmission and reflection modes can be delivered, thus bringing key performance improvements and opportunities for new communication scenarios. We here discuss the principles, benefits, and potential implementations of the proposed polarization-aided IOS, along with some key opportunities and associated challenges. </p>
<p><br></p>
<p>[Comment: This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible]</p>
Evaluation of the Possibilities of Magnetic Resonance Imaging in Monitoring the Treatment of Locally Advanced Cervical Cancer
Authors: Laryukov A. V. , Laryukova E. K. , Zidikhanov D. I. , Shakirova E. J. , Kurtasanov R. Sh. , Mindubaev E. Y. 
Published: April 2023

Background: Cervical cancer occupies one of theleading places in cancer incidence in women. Preservation of residual tumor in patients with cervical cancer after completion of combined chemoradiotherapy is a prognostically unfavorable factor. Detection of an early tumor response to chemoradiation therapy is of great importance for choosing the optimal treatment tactics.Purpose: To study the possibilities of MRI in assessing the effectiveness of detecting an early tumor response in patients with locally advanced cervical cancer after combined chemoradiotherapy.Material and methods: The results of magnetic resonance imaging of the pelvic organs, data of laboratory, cytological and postoperative histological studies of 174 patients with locally advanced cervical cancer were analyzed and compared.MRI of the pelvic organs was performed before the start of treatment to assess the extent of the process (primary study) and 6 weeks after the completion of combined chemoradiotherapy to assess the effectiveness of the treatment and detect residual tumor (control study).Conclusion: Magnetic resonance imaging of the pelvic organs using a standard research protocol, including obtaining diffusion-weighted images and dynamic contrast studies, is a highly informative method for staging locally advanced cervical cancer and assessing the tumor response to treatment.
Clinical Observation: Assessment of Factors Associated with the Refusal or Termination of Treatment in Patients with Breast Cancer
Authors: Kuznetsova A. I. , Pakhomova Ya. N. , Tsiring D. A. , Vazhenin A. V. , Ponomareva I. V. , Mironchenko M. N. , Demchuk M. A. , Gladkov Yu. O. , Novikova T. S. 
Published: April 2023

The study analyzed the clinical observation of the psychological characteristics of a woman diagnosed with breast cancer, who refused part of the proposed therapy, and had no contraindications to start special treatment.Patient Yu.F., born in 1953, diagnosis: cancer of the right breast T1NxM0 ЭР(95 %), ПР(15 %), Her2neu(0), Ki67 (5 %), refused for personal reasons from the surgical treatment proposed at the 1st stage (a written refusal was taken), in connection with which a course of hormone therapy was prescribed, a course of remote radiation therapy according to a radical program. When assessing the psychological profile of the patient, the data obtained demonstrate the presence of paradoxical hyperprotection in the patient who refused part of the treatment. Her psychological profile is similar to the psychological characteristics of women with breast cancer, whose course of the disease ended in death. In a study conducted in 2021, data were obtained on women with a negative outcome of the disease (death), who were convinced of their own luck and in the ability to control what was happening, used a wide range of coping strategies, were more resilient, are optimistic and had a pronounced internality in comparison with women in whom the disease went into stable remission.
Spatial Fractionation in Tumor Radiotherapy and Discussed Mechanisms of the Therapeutic Window Extension
Authors: Wainson A. A. , Solovieva E. V. 
Published: April 2023

Irradiation of the tumor through the ridge filters in order to reduce the damage of the normal tissues while maintaining the same damage to the neoplastic tissue as with uniform field is used for many decades. In recent years, a positive effect has been demonstrated using synchrotron radiation and beams of accelerated protons with radiation fields diminished to 25-100 micrometers with the same distances between them. Less skin damage achieved while maintaining the required level of large neoplasms eradication in the case of X-ray and gamma irradiation through ridge filters can be partially explained by the features of the physical distribution of the dose over the depth of the irradiated tissue, namely, the “merging” of fields at depth. But the good results from the use of the ‘hills and valleys’ in radiation fields created by the modern radiation sources have attracted attention to radiobiological issues for explaining the principal differences in reaction to spatial fractionation of the absorbed dose between tumor and normal tissues. We are talking about the role of the so-called ‘communal effect/bystander effect’, the effect of radiation on the immunological processes, the differences in damage and restoration of the microvasculature in normal and tumor tissue, etc. Although there is the lot of publications concerning experimental studies of the effectiveness of ‘spatial dose fractionation’, as well as those considering radiobiological mechanisms of the observed expansion of the ‘therapeutic interval’, there is still no clarity in this issue. The purpose of this review is to systematize the available data on the clinical and experimental confirmation of the effectiveness of ‘spatial fractionation’ and the various explanations of its advantages over conventional, uniform dose distribution. Special attention is paid to the issues of combination of spatial fractionation with superhigh dose rate irradiation (FLASH-radiotherapy) on the new radiation facilities, including proton accelerators, which are now in use in this country.
ESTIMATION OF LOST PROFIT OF IRRATIONAL USE OF SUBSOIL USE
Authors: Кузина Елизавета Сергеевна 
Published: April 2023

В статье рассмотрена оценка упущенной выгоды и ущерба, который нанесен недрам в результате их нерационального использования, он основан на нормативных правовых актах Российской Федерации, включающих перечень прав и обязанностей недропользователей, основные требования по рациональному использованию и охране недр, порядок установления факта правонарушения в области недропользования, ответственность за нарушение законодательства и возмещение убытков, а также порядок компенсации нанесенного ущерба от нерационального недропользования. Использование подхода позволит значительно повысить эколого-экономическую эффективность недропользования.
The article considers the assessment of lost profits and damage caused to subsoil as a result of their irrational use, it is based on the regulatory legal acts of the Russian Federation, including a list of rights and obligations of subsoil users, basic requirements for the rational use and protection of subsoil, the procedure for establishing the fact of an offense in the field of subsoil use, liability for violation of the law and compensation for losses, as well as the procedure for compensation for damage caused by irrational subsoil use. Using the approach will significantly improve the environmental and economic efficiency of subsoil use.
DIFFICULTIES OF TEXT UNDERSTANDING BY STUDENTS WITH IMPAIRED HEARING OF JUNIOR SCHOOL AGE
Authors: Дымич Яна Вагановна , Труханова Юлия Александровна 
Published: April 2023

В статье рассматриваются особенности понимания текста младшими школьниками с нарушениями слуха.
The article discusses the features of understanding the text by younger students with hearing impairments.
ROLE OF CYTOKINES AND CYTOCHROMES P450 IN METABOLISM OF ANTIVIRAL DRUGS FROM COVID-19
Authors: Баранова Надежда Ивановна , Ащина Людмила Андреевна , Болгова Александра Игоревна 
Published: April 2023

Представлен обзор данных о возможном влиянии фармакогенетических маркеров на эффективность и безопасность этиотропной терапии COVID-19. Рассматриваются клинические исследования ремдесивира, фавипиравира, молнупиравира. Описываются потенциальные фармакогенетические маркеры цитокинов, влияющие на гены семейства цитохромов P450.
A review of the data on the possible influence of pharmacogenetic markers on the efficacy and safety of COVID-19 etiotropic therapy is presented. Clinical trials of remdesivir, favipiravir, and molnupiravir are reviewed. Potential pharmacogenetic markers of cytokines affecting cytochrome P450 family genes are described.
VEGETABLE DRINKS FROM OATS. THEIR ORGANOLEPTIC PROFILE AND PHYSICO-CHEMICAL CHARACTERISTICS
Authors: Синельникова Марина Юрьевна , Матвеева Дарья Юрьевна 
Published: April 2023

Использовалось четыре типа исходного сырья с разными характеристиками и способами его подготовки. Выявлено сырье с наилучшими характеристиками для использования в технологическом процессе. С целью подтверждения качества напитков были определены показатели не только по ГОСТ, но и дополнительные показатели такие как: β -глюкан, полифенолы, аминокислоты, белки. β-глюкан известен своим свойством стабилизации уровня сахара в крови и холестерина в организме, что подтверждает его важность для определения в растительных напитках и увеличивает их функциональность. Содержание и состав фенольных компонентов в зерне зависит от его сорта и условий выращивания. Существует обратная зависимость между содержанием белка и полифенолами: чем выше содержание белка, тем ниже содержание полифенолов. В вызревшем овсе большую часть общего азота составляют белковые вещества, небелковый азот присутствует в незначительном количестве и представлен в основном аминокислотами и амидами. В рамках данной работы проведен анализ методов исследуемых веществ, а также их адаптация для применения к данному виду продукции.
Four types of raw materials were used with different characteristics and methods of their preparation. Raw materials with the best characteristics for use in the technological process have been identified. In order to confirm the quality of drinks, indicators were determined not only according to GOST, but also additional indicators such as: β-glucan, polyphenols, amino acids, proteins. β-glucan is known for its ability to stabilize blood sugar and cholesterol levels in the body, which confirms its importance for detection in plant-based drinks and increases their functionality. The content and composition of phenolic components in grain depends on its variety and growing conditions. There is an inverse relationship between protein content and polyphenols: the higher the protein content, the lower the polyphenol content. In ripened oats, protein substances make up an increasing part of the total nitrogen, non-protein nitrogen is present in an insignificant amount and is represented mainly by amino acids and amides. Within the framework of this work, an analysis of the methods of the studied substances was carried out, as well as their adaptation for application to this type of product.
EFFECTIVE EMPLOYMENT CONTRACT WITH A TEACHER: PAST AND PRESENT
Authors: Хабиева Елена Викторовна 
Published: April 2023

Эффективный трудовой договор с преподавателями средних профессиональных образовательных организаций - способ практической реализации гарантий работнику по достойной оплате труда, складывающейся из базовой части оплаты труда (тарифная ставка, оклад), компенсационных и стимулирующих выплат, а также выплат социального характера.
An effective employment contract with teachers of secondary vocational educational organizations is a way of practical implementation of guarantees to the employee for decent wages, consisting of the basic part of wages (wage rate, salary), compensation and incentive payments, as well as payments of social character.
Cosmological-model-independent Determination of Hubble Constant from Fast Radio Bursts and Hubble Parameter Measurements
Authors: Liu Yang , Yu Hongwei , Wu Puxun 
Published: April 2023

Abstract
We establish a cosmological-model-independent method to determine the Hubble constant H
0 from the localized fast radio bursts (FRBs) and the Hubble parameter measurements from cosmic chronometers and obtain a first such determination H
0 = 71 ± 3 km s−1 Mpc−1, with an uncertainty of 4%, from the eighteen localized FRBs and nineteen Hubble parameter measurements in the redshift range 0 < z ≤ 0.66. This value, which is independent of the cosmological model, is consistent with the results from the nearby Type Ia supernovae (SNe Ia) data calibrated by Cepheids and the Planck cosmic microwave background radiation observations at the 1σ and 2σ confidence level, respectively. Simulations show that the uncertainty of H
0 can be decreased to the level of that from the nearby SNe Ia when mock data from 500 localized FRBs with 50 Hubble parameter measurements in the redshift range of 0 < z ≤ 1 are used. Since localized FRBs are expected to be detected in large quantities, our method will be able to give a reliable and more precise determination of H
0 in the very near future, which will help us to figure out the possible origin of the Hubble constant disagreement.
The Behavior of Bp He-weak Stars in the Far UV—Paper III: HD 175362
Authors: Monier Richard 
Published: April 2023

Abstract
The analysis of twelve spectra of the Bp He-weak Si star HD 175362 recorded by the SWP camera on board the International Ultraviolet Explorer reveals variations of the far-ultraviolet spectral energy distribution over a time interval of several years. Variations are present shortwards of 1700 Å which can be partly attributed to variations of lines and continuum of Si ii. Other lines due to C ii, Si iii and Si iv also contribute to the opacity in this range too. The variations suggest that silicon and carbon are not distributed in a uniform manner over the surface.