bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN PEMBELAJARAN “MIKIR” UNTUK MENINGKATKAN SIKAP PEDULI LINGKUNGAN DAN HASIL BELAJAR PADA SISWA KELAS VIIB SMP NEGERI 1 WURYANTORO
Authors: Setyorini Endah 
Published: April 2023

Penelitian ini dilatar belakangi dari permasalahan di kelas VIIB yaitu sikap peduli lingkungan siswa yang rendah, terbukti dengan masih banyak siswa yang tidak peduli terhadap kebersihan lingkungan yang ditunjukkan dengan kelas dibiarkan kotor, banyaknya sampah yang masih berserakan di depan kelas dan dilaci meja, tempat sampah yang sudah penuh tapi tidak segera dibuang, serta banyaknya sampah plastik yang tercecer di selokan, siswa juga belum memanfaatkan sampah plastik untuk membuat sebuah hasta karya, masih banyak siswa yang tidak mau membuang sampah pada tempatnya, dan membiarkan saja sampah yang ada di kelas, serta hasil tes awal di kelas VIIB juga menunjukan hasil yang rendah, yaitu dari 28 siswa hanya 11 siswa (39,3%) yang nilainya mencapai Kriteria Ketuntasan Minimal (KKM). Penelitian ini bertujuan untuk meningkatkan sikap peduli lingkungan, nilai pengetahuan, dan nilai keterampilan siswa melalui penerapan pembelajaran MIKIR. Penelitian ini merupakan penelitian tindakan kelas dengan subyek penelitian siswa kelas VIIB SMP Negeri 1 Wuryantoro yang berjumlah 28 siswa, teknik pengumpulan datanya dengan angket, observasi, tes tertulis, wawancara, dan dokumentasi. Hasil penelitian ini menunjukan ada peningkatan nilai sikap peduli lingkungan, nilai pengetahuan, maupun nilai keterampilan siswa. Penilaian sikap, pengetahuan, dan keterampilan terjadi peningkatan tiap siklusnya.
KORELASI ANTARA PEMAHAMAN LAYANAN INFORMASI DENGAN MOTIVASI BELAJAR SISWA KELAS VIII DI MASA PANDEMI SMP NEGERI 1 MANYARAN TAHUN PELAJARAN 2021/2022
Authors: Wandono Koni 
Published: April 2023

Penelitian ini membahas tentang korelasi antara pemahaman layanan informasi dengan motivasi belajar siswa kelas VIII di masa pandemi SMP Negeri 1 Manyaran tahun pelajaran 2021/2022. Tujuan penelitian untuk mengetahui kategori pemahaman layanan informasi, kategori motivasi belajar siswa, dan mengetahui korelasi antara pemahaman layanan informasi (X) dengan motivasi belajar siswa kelas (Y) kelas VIII di masa pandemi SMP Negeri 1 Manyaran tahun pelajaran 2021/2022. Penelitian ini menggunakan pendekatan kuantitatif, sedangkan pengumpulan data dilakukan dengan instrumen angket dan dokumentasi. Populasi penelitan ini adalah seluruh siswa kelas VIII SMP Negeri 1 Manyaran tahun pelajaran 2021/202 sebesar 177 siswa. Sampel dalam penelitian ini sebesar 35 siswa dengan menggunakan teknik sampel acak sederhana (simple random sampling). Hasil penelitian ini adalah; (1) pemahaman layanan informasi kategori rendah sebanyak 5,71%, sedang 60,00% dan tinggi 34,29%. (2) motivasi belajar siswa kategori rendah sebanyak (2,86%), sedang 20,00%) dan tinggi 77,14%. (3) Hasil uji hipotesis yang dikonsultasikan dengan harga r tabel product moment, menunjukkan: r hitung > tingkat signifikan 5% (hipotesis diterima). Hasil analisis dengan korelasi product moment menunjukkan harga koefisien korelasi sebesar 0,765 sedang harga r tabel dengan taraf signifikan 5% adalah 0,334. Harga r hitung lebih besar dari r tabel., ini adanya hubungan yang signifikan antara pemahaman layanan informasi dengan motivasi belajar siswa kelas VIII di masa pandemi SMP Negeri 1 Manyaran tahun pelajaran 2021/2022.
PENINGKATAN PENGUASAAN KOSA KATA BAHASA INGGRIS MELALUI KEGIATAN SUPER CAMP KELAS XII IPA1 SMAN 1 GIRIMARTO
Authors: Sukatno Sukatno 
Published: April 2023

Penelitian ini bertujuan untuk meningkatkan penguasaan kosa kata bahasa Inggris. Salah satu cara untuk meningkatkan kemampuan jenis ini adalah melalui kegiatan pembelajaran di luar kelas dalam situasi kamping sehari atau dinamai Super Camp berbahasa Inggris. Melalui kegiatan pembelajaran super camp ,siswa diberi kesempatan seluas-luasnya untuk mengembangkan potensi secara total dengan kegiatan pembelajaran melalui pengalaman langsung: siswa mengalami sendiri/praktik dalam proses pembelajaran. Penelitian ini melalui pemberian tindakan, ini dilaksanakan mulai awal bulan September awal sampai dengan akhir September tahun 2022. Subyek penelitian adalah siswa kelas XII IPA1 yang berjumlah 30 siswa. Peneliti menyelenggarakan tindakan dalam dua siklus atau putaran. Tiap siklus terdiri dari identifikasi masalah, perencanaan tindakan, pemberian tindakan, pengamatan dan refleksi hasil observasi dan merevisi perencanaan. Teknik pengumpulan data meliputi; (1) pengamatan semua kegiatan proses pembelajaran; (2) tes, untuk mengetahui apakah ada peningkatan kemampuan siswa. Dalam kegiatan penelitian tindakan kelas ini peneliti dibantu oleh seorang kolaborator (guru serumpun). Hasil dari penelitian tindakan kelas ini adalah terjadi peningkatan penguasaan kosa kata bahasa Inggris. Terbukti nilai rerata kemampuan penguasaan kosa kata bahasa Inggris sebelum tindakan sebesar 70, sedangkan setelah tindakan menjadi 80. Berdasar data penelitian telah terjadi peningkatan prestasi belajar siswa, setelah mereka mengikuti proses pembelajaran melalui model SUPER CAMP berbahasa Inggris.
Mémoire et histoire dans les communautés francophones minoritaires : réflexions d’un praticien1
Authors: Frenette Yves 
Published: April 2023

Les historiens contribuent à la construction de la mémoire collective. Cependant, par le biais d’enquêtes méthodiques, leur apport diffère souvent de celui d’autres intervenants. S’ils peuvent être aussi des citoyens engagés, les historiens doivent pratiquer une nécessaire mise à distance. Or, cet équilibre est difficile à maintenir dans les communautés francophones minoritaires. Marginalisées sous plus d’un aspect, ces dernières sont constamment à la recherche de justice et de reconnaissance. Dans leurs combats, les porte-parole des minorités multiplient les références à l’ancrage profond des francophones dans le territoire et à leurs luttes héroïques, croyant ou voulant croire que « la communauté » a toujours été unanime.
Le présent article vise à saisir les rapports qu’entretiennent la mémoire et l’histoire au sein des communautés francophones minoritaires. Pour ce faire, l’auteur s’appuie sur les travaux d’historiens d’ici et d’ailleurs qui ont étudié la question, et il illustre ses propos en donnant des exemples récents. Partiellement analytique, l’article se veut également un témoignage qui repose sur diverses expériences de l’auteur en Ontario français.
L’« égalité des armes » — une expression bénie ? — en droit processuel au Québec : le rôle du droit international
Authors: Beaulac Stéphane 
Published: April 2023

Si l’« égalité des armes » en est à ses balbutiements en droit processuel au Québec, son potentiel de croissance semble considérable. Après en avoir défini la nature et vu ses ancrages juridiques — l’article 23 de la Charte des droits et libertés de la personne du Québec et les principes directeurs du Code de procédure civile — et à la suite d’un bref examen des quelques affaires y ayant eu recours en jurisprudence, la discussion se concentre sur la filiation de droit international du principe. Pour ce faire, il faut bien comprendre la grille d’analyse de la problématique de l’interlégalité, qui a été recadrée et raffinée récemment. La Cour suprême du Canada enseigne que la normativité internationale procure des éléments « pertinents et persuasifs » ou des éléments contextuels pour l’interprétation et l’application du droit interne, étant entendu que son rôle se limite à appuyer ou à confirmer (jamais contredire) une conclusion qui se fonde, au premier chef, sur le texte de la législation. En outre, l’analyse est différenciée suivant le type de sources : convention contraignante ou non, instrument antérieur ou postérieur à la loi interne, jurisprudence de tribunaux internationaux ou étrangers. La seconde partie du texte procède à l’étude en substance de l’égalité des armes, telle que développée en vertu des conventions des systèmes régionaux européens et sous le régime universel onusien, et telle qu’articulée à l’aide de décisions de tribunaux internationaux (Cour européenne des droits de l’homme; Cour de justice de l’Union européenne). On constate ensuite que les jugements au Québec ayant fait référence au principe ne se sont pas trompés : ils ont considéré l’égalité des armes tout d’abord dans une perspective de droit interne, en tenant compte de l’article 23 de la Charte des droits et libertés de la personne du Québec et des principes directeurs du Code de procédure civile, pour arriver seulement par la suite au droit international, afin d’appuyer et de confirmer le sens et la portée du principe. Bien que le texte soit articulé autour de l’international, en conclusion, des exemples d’application en droit procédural au Québec sont présentés. En définitive, l’égalité des armes pourra certes se déployer pleinement grâce à ses ancrages juridiques internes et, en outre, à la lumière de l’expérience internationale.
Exploring the role of differentially expressed metabolic genes and their mechanisms in bone metastatic prostate cancer
Authors: Zhang Qingfu , Zhang Peng , Zhao Zhongting , Wang Jun , Zhang Hepeng 
Published: April 2023

Background
Approximately 10–20% of patients diagnosed with prostate cancer (PCa) evolve into castration-resistant prostate cancer (CRPC), while nearly 90% of patients with metastatic CRPC (mCRPC) exhibit osseous metastases (BM). These BM are intimately correlated with the stability of the tumour microenvironment.

Purpose
This study aspires to uncover the metabolism-related genes and the underlying mechanisms responsible for bone metastatic prostate cancer (BMPCa).

Methods
Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets of PCa and BM were analyzed through R Studio software to identify differentially expressed genes (DEGs). The DEGs underwent functional enrichment via Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO), with key factors screened by a random forest utilized to establish a prognostic model for PCa. The study explored the relationship between DEGs and the stability of the immune microenvironment. The action and specificity of CRISP3 in PCa was validated through western blot analysis, CCK-8 assay, scratch assay, and cellular assay.

Results
The screening of GEO and TCGA datasets resulted in the identification of 199 co-differential genes. Three DEGs, including DES, HBB, and SLPI, were selected by random forest classification model and cox regression model. Immuno-infiltration analysis disclosed that a higher infiltration of naïve B cells and resting CD4 memory T cells occurred in the high-expression group of DES, whereas infiltration of resting M1 macrophages and NK cells was greater in the low-expression group of DES. A significant infiltration of neutrophils was observed in the high-expression group of HBB, while greater infiltration of gamma delta T cells and M1 macrophages was noted in the low-expression group of HBB. Resting dendritic cells, CD8 T cells, and resting T regulatory cells (Tregs) infiltrated significantly in the high-expression group of SLPI, while only resting mast cells infiltrated significantly in the low-expression group of SLPI. CRISP3 was established as a critical gene in BMPCa linked to DES expression. Targeting CRISP3, d-glucopyranose may impact tumour prognosis. During the mechanistic experiments, it was established that CRISP3 can advance the proliferation and metastatic potential of PCa by advancing epithelial-to-mesenchymal transition (EMT).

Conclusion
By modulating lipid metabolism and maintaining immunological and microenvironmental balance, DES, HBB, and SLPI suppress prostate cancer cell growth. The presence of DES-associated CRISP3 is a harbinger of unfavorable outcomes in prostate cancer and may escalate tumor proliferation and metastatic capabilities by inducing epithelial-mesenchymal transition.
Identification of key genes in bovine muscle development by co-expression analysis
Authors: Zhang Junxing , Sheng Hui , Pan Cuili , Wang Shuzhe , Yang Mengli , Hu Chunli , Wei Dawei , Wang Yachun , Ma Yun 
Published: April 2023

Background
Skeletal muscle is not only an important tissue involved in exercise and metabolism, but also an important part of livestock and poultry meat products. Its growth and development determines the output and quality of meat to a certain extent, and has an important impact on the economic benefits of animal husbandry. Skeletal muscle development is a complex regulatory network process, and its molecular mechanism needs to be further studied.

Method
We used a weighted co-expression network (WGCNA) and single gene set enrichment analysis (GSEA) to study the RNA-seq data set of bovine tissue differential expression analysis, and the core genes and functional enrichment pathways closely related to muscle tissue development were screened. Finally, the accuracy of the analysis results was verified by tissue expression profile detection and bovine skeletal muscle satellite cell differentiation model in vitro (BSMSCs).

Results
In this study, Atp2a1, Tmod4, Lmod3, Ryr1 and Mybpc2 were identified as marker genes in muscle tissue, which are mainly involved in glycolysis/gluconeogenesis, AMPK pathway and insulin pathway. The assay results showed that these five genes were highly expressed in muscle tissue and positively correlated with the differentiation of bovine BSMSCs.

Conclusions
In this study, several muscle tissue characteristic genes were excavated, which may play an important role in muscle development and provide new insights for bovine molecular genetic breeding.
Phytochemical Screening and Evaluation of the Anti-Salmonella Activity of Leaf Extracts of Telfairia occidentalis Hook. F. (Cucurbitaceae) on Salmonella typhii Cell Culture
Authors: Tamanji VL , Tembe EAF , Mbong GA , Bayaga H , Njinkio BN , Fonmboh DJ , Tchadji MV , Moody JO , Gonsu HK , Fokunang CN 
Published: April 2023

Typhoid fever, a bacterial infection caused by Salmonella typhi whose treatment is by use of antibiotics. And the use of these antibiotics associated with drug resistance, high cost of medication and less accessibility to rural populations remains an issue of concern. The aim of this research was to indentify bioactive metabolites of the leaf of T. occidentalis and determine the anti-salmonella typhi activity. The antibacterial activity of the leaf extracts (aqueous maceration, decoction, infusion and ethanol maceration) of Telfairia occidentalis (Fluted pumpkin or gourd) on Salmonella typhi, was determined using the agar well diffusion technique to investigate its potential use as anti-bacterial agent. The phyto-chemical constituents, Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the leaf was analyzed. The phytochemical analysis of the extracts showed the presence of saponins, flavonoids, tannins, phenolics and coumarin with the absence of phlobatanins and oxalates. The decoction of the leaves demonstrated the highest activity against S. typhi (15+/-2.7mm) at 1000mg/ml. MIC for aqueous maceration, infusion, and decoction was recorded at 62.5mg/ml and that of the ethanol maceration was at 15.625mg/ml. Due to the extraordinarily high concentration of extract needed to produce anti-salmonella activity, the study's findings imply that the leaf extract has negligible activity against Salmonella.
Determination of Knowledge Based on Aflatoxin Poisoning among Broiler Farmers in Nairobi City County, Kenya
Authors: Chepkosgei Kirinyet Ruth , Njogu Warutere Peterson , Purity Nguhiu , Patroba Ojola , Joel Kirinyet , Peter Koskei 
Published: April 2023

Background: There is a scarcity of information concerning knowledge of aflatoxin contamination of feeds among farmers even in aflatoxin-prone regions in Kenya. Thus, knowledge of aflatoxins in feeds among poultry farmers is of paramount importance in designing plans to minimize risks of aflatoxin exposure. Therefore, this study sought to assess the Determinants of Knowledge on Aflatoxin Among Broiler farmers in Nairobi City County, Kenya.
Methodology: The study utilized an analytical cross-sectional study design. A total of 240 farmers were sampled from a population of 600 farmers within Nairobi City County. A structured questionnaire was administered to farmers within Nairobi City County. SPSS version 26 was used to analyze the data descriptively. Results were presented in tables and figures. Ethical approval was sought from relevant authorities and parties before the commencement of the study.
Results: Results from the study show that the majority of the farmers (58.2%) had knowledge of aflatoxin. There was a significant association (p<0.05) between the socio-demographic characteristics of farmers and knowledge of aflatoxin.
Conclusion: The study concludes that the farmers had adequate knowledge of aflatoxin occurrence in feeds and methods to reduce the contamination. There is a need for continuous sensitization of farmers on aflatoxin, particularly on feed management practices by the Ministry of Agriculture and Ministry of Health Division of Public Health in Kenya.
Effect of Intrapleural Fibrinolytic Therapy vs Surgery for Complicated Pleural Infections
Authors: Wilshire Candice L. , Jackson Anee S. , Vallières Eric , Bograd Adam J. , Louie Brian E. , Aye Ralph W. , Farivar Alexander S. , White Peter T. , Gilbert Christopher R. , Gorden Jed A. 
Published: April 2023

ImportanceThere is a paucity of high-quality prospective randomized clinical trials comparing intrapleural fibrinolytic therapy (IPFT) with surgical decortication in patients with complicated pleural infections.ObjectiveTo assess the feasibility, safety, and efficacy of an algorithm comparing tissue plasminogen activator plus deoxyribonuclease therapy with surgical decortication in patients with complicated pleural infections.Design, Setting, and ParticipantsThis parallel pilot randomized clinical trial was performed at a single urban community-based center from March 1, 2019, to December 31, 2021, with follow-up for 90 days. Seventy-four individuals were screened and 48 were excluded. Twenty-six patients 18 years or older with clinical pleural infection and positive findings of pleural fluid analysis were included. Of these, 20 patients underwent randomized selection (10 in each group), and 6 were observed.InterventionsIntrapleural tissue plasminogen activator plus deoxyribonuclease therapy vs surgical decortication.Main Outcomes and MeasuresPrimary outcomes were the percentage of patients enrolled to study completion and multidisciplinary adherence. Secondary outcomes included the number of patients with and the reason for inadequate screening, screening to enrollment failures, time to accrual of 20 patients or the number accrued at 1 year, and clinical data.ResultsTwenty-six patients were enrolled, 10 were randomized to each group, and 6 were observed. There was 100% enrollment to study completion in each treatment group, no protocol deviations, 2 minor protocol amendments, and no screening to enrollment failures. It took 32 months to enroll 26 patients. The 20 randomized patients had a median age of 57 (IQR, 46-65) years, were predominantly men (15 [75%]), and had a median RAPID (Renal, Age, Purulence, Infection Source, and Dietary Factors) score of 2 (IQR, 1-3). Treatment failure occurred in 1 patient and 2 crossover treatments occurred, all of which were in the IPFT group. Intraprocedure and postprocedure complications were similar between the groups. There were no reoperations or in-hospital deaths. Median duration of chest tube use was comparable in the IPFT (5 [IQR, 4-8] days) and surgery (4 [IQR, 3-5] days) groups (P = .21). Median hospital stay tended to be longer in the IPFT (11 [IQR, 4-18] days) vs surgery (5 [IQR, 4-6] days) groups, although the difference as not significantly different (P = .08). There were no 30-day readmissions or 30- or 90-day deaths.Conclusions and RelevanceIn this pilot randomized clinical trial, the study algorithm was feasible, safe, and efficacious. This provides evidence to move forward with a multicenter randomized clinical trial.Trial RegistrationClinicalTrials.gov Identifier: NCT03873766
Ketamine vs Electroconvulsive Therapy for Major Depressive Episode
Authors: Menon Vikas , Varadharajan Natarajan , Faheem Abdul , Andrade Chittaranjan 
Published: April 2023

ImportanceThe relative efficacy of ketamine and electroconvulsive therapy (ECT) in adults with major depressive episode (MDE) needs clarification.ObjectiveTo compare depression rating outcomes with ketamine vs ECT in adults with MDE and to compare response and remission rates, number of sessions to response and remission, and adverse effects.Data SourcesTwo investigators independently systematically searched MEDLINE, ScienceDirect, and Google Scholar databases using a combination of relevant Medical Subject Headings terms and free-text keywords from database inception through May 15, 2022, to identify relevant English-language trials.Study SelectionParallel-group randomized clinical trials (RCTs).Data Extraction and SynthesisTwo investigators independently extracted data and assessed risk of bias. One-week posttreatment outcomes were pooled as standardized mean difference (SMD; Hedges g) for continuous outcomes and risk ratio (RR) for categorical outcomes in random-effects meta-analyses.Main Outcomes and MeasuresEfficacy outcomes were 1-week (or nearest) posttreatment depression ratings, 1-week (or nearest) study-defined response and remission rates, and number of sessions to treatment response and remission. Safety outcomes were reported adverse effects.ResultsFive trials (ketamine group: n = 141; ECT group: n = 137) were meta-analyzed. The overall pooled SMD for posttreatment depression ratings was −0.39 (95% CI, −0.81 to 0.02; I2 = 45%; 5 RCTs). For this efficacy outcome, in a sensitivity analysis of methodologically stronger trials, ECT was superior to ketamine (SMD, −0.45; 95% CI, −0.75 to −0.14; I2 = 6%; 2 RCTs). ECT was also superior to ketamine for study-defined response (RR, 1.27; 95% CI, 1.06-1.53; I2 = 0%; 3 RCTs) and remission (RR, 1.43; 95% CI, 1.12-1.82; I2 = 0%; 2 RCTs) rates. No significant differences were noted between groups for number of sessions to response and remission and for cognitive outcomes. Key limitations were small number of studies, limited sample size, and high risk of bias in all trials.Conclusion and RelevanceThe findings of this systematic review and meta-analysis suggest an efficacy advantage for ECT over ketamine in adults with MDE. These conclusions are tempered by the small number and size of existing trials.