bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective analysis of the diagnostic accuracy of digital rectal examination and magnetic resonance imaging for T staging of prostate cancer
Authors: Zhu Junming , Wu Xiaohui , Xue Yuting , Li Xiaodong , Zheng Qingshui , Xue Xueyi , Huang Zhiyang , Chen Shaohao 
Published: August 2023

ABSTRACT

Background:
Accurate staging of prostate cancer (PCa) is the basis for the risk stratification to select targeted treatment. Therefore, this study aimed to compare the diagnostic accuracy rates of magnetic resonance imaging (MRI) and digital rectal examination (DRE) for preoperative T staging of potentially resectable PCa.

Methods:
From March 2021 to March 2022, patients with PCa with T staging by prostate biopsy were included. All examinations used postoperative histopathologic T staging as the reference standard. All patients underwent DRE and MRI before the puncture. Two blinded urologists and radiologists independently evaluated DRE and MRI, respectively. Before the examination, patients were then divided into early- (T1, T2) and late-(T3, T4) stage cancer. Analysis of a paired sample sign test was performed to determine differences between DRE and MRI.

Results:
A total of 136 study participants with PCa were evaluated histopathologically, of whom 71% (97/136) and 29% (39/136) were at the early- and late-stage cancer, respectively. MRI had a significantly higher accuracy (91.9% vs. 76.5%, P < 0.001) compared with DRE. Further, MRI showed a higher sensitivity than DRE to diagnose early PCa (92.8% vs. 74.2%; P < 0.001). However, the specificity was not significantly different between them (89.7% vs. 82.1%; P = 0.375). Area under the curve (receiver operating curve) values were calculated as 0.78 ± 0.038 (95% confidence interval [CI], 0.71–0.86), 0.91 ± 0.028 (95% CI, 0.86–0.97), and 0.872 ± 0.028 (95% CI, 0.80–0.92) for DRE-, MRI-, MRI + DRE-based PCa predictions, respectively. The prediction performance of MRI was better than that of DRE (DeLong test, z = 3.632, P = 0.0003) and MRI + DRE (DeLong test, z = 3.715, P = 0.0002).

Conclusion:
For resectable PCa, the diagnostic potential of MRI in assessing the T stage was higher than that of DRE. However, DRE is still valuable, especially for patients with locally advanced PCa.
Pediatric granular cell tumor of the larynx: A case report and literature review
Authors: Ke Jing , Xiong Junwei , Zhang Juhong , Ma Haiyu , Yuan Wei 
Published: August 2023

ABSTRACT
An 8-year-old child was admitted to our ENT department for a year because of a hoarse voice. An endoscopic examination displayed that a cystic, solid lesion can be seen in the right subglottis. The lesion was removed using a CO2 laser under general anesthesia. Postoperative histopathology confirmed granular cell tumor (GCT), S-100(+), vimentin (+), and SOX-10(+). GCT, also known as the Abrikossoff tumor, is a rare benign tumor that rarely occurs in the larynx, particularly in children. This case report emphasizes that considerable attention should be given to the differential diagnosis of the laryngeal granulosa cell tumor. Given the recurrence risk of GCT, long-term postoperative follow-up is necessary.
Clinical application of radiofrequency ablation-assisted coaxial trocar biopsies for pulmonary nodules at a high risk of bleeding
Authors: Zhu Shidi , Li Jing , Guan Weiwei , Li Hailiang , Fan Weijun , Wu Di , Zheng Lin 
Published: August 2023

ABSTRACT

Context:
The purpose of this study was to assess computed tomography (CT)-guided puncture biopsy of pulmonary nodules at a high risk of bleeding. First, a coaxial trocar technique was used to radiofrequency ablate small blood vessels in the puncture area, followed by a biopsy of the pulmonary nodule.

Aim:
This study aimed to evaluate the effectiveness and safety of this procedure.

Methods:
In this retrospective research, we assessed the relevant data of 45 patients who had undergone needle biopsy of pulmonary nodules at a high risk of bleeding. Twenty-five of these patients had CT-guided coaxial radiofrequency ablation (RFA)-assisted biopsy (group A). The remaining 20 had undergone conventional CT-guided needle biopsy (group B). We equated the technical success rate and the incidence of complications such as bleeding, pneumothorax, and pain in the two groups of needle biopsies.

Results:
Both groups had a 100% success rate with puncture biopsy. The incidences of pneumothorax in groups A and B were 10% (2/20) and 24% (6/25), respectively; this difference is not significant (P > 0.050). The rates of bleeding in groups A and B were 10% (2/20) and 44% (11/25), respectively, and the rates of pain were 30% (6/20) and 60% (15/25), both of which were statistically significant (P = 0.030; P = 0.045, respectively).

Conclusions:
CT-guided coaxial trocar technique for RFA-assisted biopsy of pulmonary nodules at a high risk of bleeding is effective and safe and can significantly reduce the risk of biopsy-induced pulmonary hemorrhage.
High-power green-light laser endoscopic submucosal dissection for non-muscle-invasive bladder cancer: A technical improvement and its initial application
Authors: Zheng Jilu , Liu Feifan , Zhang Keqin , Xiang Yuzhu , Li Lianjun , Zhang Haiyang , Zhang Yinan , Suo Ning , Wang Zilong , Han Chenglin , Jin Xunbo , Wang Muwen , Wei Chunxiao , Chen Ji 
Published: August 2023

ABSTRACT

Background:
The technique of laser en bloc resection of bladder tumor (ERBT) has been a valuable alternative technique to transurethral resection of bladder tumor (TURBT). However, the combination of laser ERBT and endoscopic submucosal dissection (ESD) technique has not been well studied. Here, a novel technique integrating a high-power green-light laser with ESD was presented. This study aimed to evaluate the safety and efficacy of high-power green-light laser endoscopic submucosal dissection (HPL-ESD) for the treatment of primary non-muscle-invasive bladder cancer (NMIBC).

Materials and Methods:
From January 2015 to December 2018, a total of 56 patients with NMIBC underwent HPL-ESD. All tumors were transurethral en bloc resected in the ESD technique. Perioperative clinical data were retrospectively collected and analyzed.

Results:
All operations were safely performed by the technique of HPL-ESD without blood transfusion. The mean tumor diameter was 2.04 ± 0.65 cm, ranging from 0.5 to 3.5 cm. The mean operative time was 28.39 ± 16.04 min. The average serum hemoglobin decrease was 0.88 ± 0.54 g/dL. The mean postoperative catheterization time was 2.88 ± 0.94 days. The pathologic stages included pTa (32 cases), and pT1 (24 cases). Double-J stent indwelling was not performed for four patients whose tumors were adjacent to the ureteral orifice and no postoperative hydronephrosis was observed. Only one case of ectopic bladder tumor recurred due to irregular bladder irrigation during the 36-month follow-up.

Conclusion:
HPL-ESD is a safe and effective alternative for the treatment of primary NMIBCs, especially for tumors adjacent to the ureteral orifice.
Immunotherapy for early-stage non-small cell lung cancer: A system review
Authors: Gao Jingyi , Zhang Chao , Wei Zhigang , Ye Xin 
Published: August 2023

ABSTRACT
With the addition of immunotherapy, lung cancer, one of the most common cancers with high mortality rates, has broadened the treatment landscape. Immune checkpoint inhibitors have demonstrated significant efficacy in the treatment of non-small cell lung cancer (NSCLC) and are now used as the first-line therapy for metastatic disease, consolidation therapy after radiotherapy for unresectable locally advanced disease, and adjuvant therapy after surgical resection and chemotherapy for resectable disease. The use of adjuvant and neoadjuvant immunotherapy in patients with early-stage NSCLC, however, is still debatable. We will address several aspects, namely the initial efficacy of monotherapy, the efficacy of combination chemotherapy, immunotherapy-related biomarkers, adverse effects, ongoing randomized controlled trials, and current issues and future directions for immunotherapy in early-stage NSCLC will be discussed here.
Immediate cause and the role of multimorbidity in deaths associated with COVID 19 among hospitalized patients in a low resource district in Kerala India: A record-based case-control analysis
Authors: Vaman Raman Swathy , Valamparampil Mathew J. , Dalmita Niya James , Reghukumar Aravind , Anish T. S. 
Published: August 2023

Introduction:
Multimorbidity is the coexistence of two or more chronic medical conditions in a person. The study aims to investigate the immediate cause of death and risk factors of mortality including multimorbidity among patients hospitalized with SARS CoV2 infection in Kasaragod district in Kerala, India.

Methods:
A record-based case-control study was done using the hospital records and follow-up surveillance system of SARS-COV 2 patients admitted in the Kasaragod district. SARS-COV 2 patients who had expired during the study period from June to December 2020 and reported as COVID-19 deaths (N = 226) were the cases, and an equal number of hospital controls were the study participants.

Results:
The mean (SD) age of the cases and controls were found to be 64.6 (14.2) years and 61.5 (13.4) years, respectively. Covid pneumonia alone was reported as the cause of death in more than half (52%) of the study participants. This was followed by cardiovascular events (8.5%) and acute kidney injury (6.5%). Among individual comorbidities among people who expired, diabetes mellitus (53%) was the most common, followed by hypertension (46%) and cardiovascular diseases (23%). More than 50% were found to have multimorbidity. Logistic regression showed chronic kidney disease (CKD) (Adjusted odds ratio (AOR) = 2.18 (1.24–3.83)) and malignancy (AOR = 3.05 (1.27–7.32)) to be significantly associated with mortality as individual determinants. Hypertension–diabetes mellitus [AOR = 1.68 (1.02–2.76), P = 0.043] and hypertension–CKD [AOR = 3.49 (1.01–12.01), P = 0.48] dyads were multimorbidities significantly associated with mortality.

Conclusion:
Combinations of hypertension with diabetes mellitus and CKD were found to be significant determinants for mortality in hospitalized COVID-19 patients. Uniformity in death certification is required to understand the causes and contributors to death in COVID-19.
Immunological survey of COVID-19 among medicos of tribal preponderant state of India
Authors: Kumari Sushma , Jeseena K , Kiran Asha K. , Kujur Manisha , Saroj Usha , Hembrom Shailesh S. , Kujur Anit 
Published: August 2023

Background:
Immunological Survey or serosurveys have yielded useful information regarding the spread of the COVID-19 pandemic in the general population, but the impact of the continuing pandemic on the medical students in India is yet to be fully recognised. In this study we assessed the students who had received at least two doses of the COVID-19 vaccine for their antibody response.

Methodology:
A Hospital based, age-stratified, cross-sectional Analytical study design was adopted for the survey, carried out in tribal state of India among medical students. Consecutive sampling method was used where serum samples were tested for antibodies against the SARS-CoV-2 nucleocapsid (N) protein.

Result:
The vaccinee group comprised of 187 students mostly aged between 18-23 years 68.4% were females, 56.6 % were vaccinated with covishield. The mean IgG (Immunoglobin G) titre was 7343.74 AU/Ml, less than 1000 AU/Ml was found in 8% of participants, while more than 8000 AU/Ml was found in 32.1%. Participants who got the covaxin vaccine had a higher median IgG titre (median 6491.8 AU/mL, interquartile range 8898 AU/mL).The antibody titre of male was 0.328 times lower than that of female.

Conclusion:
Despite the fact that covishield’s mean antibody titre was higher, covaxin’s protection lasted longer.
General Practitioners’ Knowledge, Attitudes and Practices towards Health Promotion in Morocco
Authors: Mansoury Ouassim , Essoli Samira , Kachkouch Hamza , Mansouri Adil , Adarmouch Latifa , Amine Mohamed , Sebbani Majda 
Published: August 2023

Background:
Health promotion (HP) is a part of the general practitioners’ (GPs) competencies defined by the World Organization of Family Doctors. The implementation of HP in their practice is unsatisfactory.

Aims:
The aim of this study was to explore GPs knowledge, attitudes and practices in Morocco about HP at the primary healthcare services.

Methods:
A cross-sectional study was conducted using an online self-administrated questionnaire including, knowledge, attitudes and practices of GPs toward HP. Descriptive and bivariate analyses were conducted.

Results:
Two hundred and forty GPs responded to our questionnaires, the sex ratio was 1.12 with an average age of 40.46 ± 9.05 years. More than half of our participants perceived HP as a concept indistinct from prevention, 70.4% believed that HP refers to the biomedical model. On a Likert scale of 1–5, the level of HP knowledge was 2.71 ± 1.13. The most discussed topics with the population were tobacco, alcohol, overweight and obesity. Statistically significant association was found between the competencies of GPs in lifestyle behaviours and the practice of this competence.

Conclusion:
The knowledge of GPs remains insufficient, and their practices focus more on the areas in which they feel competent, which requires the implementation of specific training for the development of GPs skills in HP.
Knowledge and perception of telerehabilitation in patients with chronic neurological conditions
Authors: Jain Nikhil , Chavhan Dinesh , Dabadghav Rachana , Shyam Ashok , Sancheti Parag 
Published: August 2023

BACKGROUND:
Telerehabilitation (TR) delivers rehabilitation across a distance using information and communication technologies. It has several potential advantages over in-person rehabilitation. It can improve patient access to rehabilitation services and reduce monetary, time, and environmental costs associated with travel.

AIM:
The aim of this study was to assess the knowledge and perception of TR in patients with chronic neurological conditions.

SETTING:
It was a community and tertiary care.

DESIGN:
It was a questionnaire-based survey.

SUBJECTS AND METHODS:
A self-made questionnaire was validated and circulated physically and online through Google Forms to the patients with chronic neurological conditions who have undergone TR or at least have some idea about it. One hundred seven patients who fit under the inclusion criteria filled out the form after giving consent. The responses were collected; descriptive data analysis was done; and results were obtained. Descriptive analysis was done by calculating mean and standard deviation.

RESULTS:
Out of 107 participants recruited for the research, 83 (77.6%) were males and 24 (22.4%) were females. Out of these, 51 (47.40%) are aware of TR but have never used it, 43 (40.20%) use it as advised by physiotherapists/doctors, and 13 (12.10%) use it only sometimes. None of them uses it regularly.

CONCLUSION:
From this study, it can be concluded that there is a significant amount of knowledge and perception of TR in chronic neurological patients, required they have at least some idea about TR. It is used most commonly in patients with stroke, followed by traumatic brain injury and spinal cord injury.
Musculoskeletal injuries in salespersons: A survey study
Authors: Phatak Janhavi Vinay , Joseph Sibi Daniel 
Published: August 2023

BACKGROUND:
Salespersons job includes prolonged standing and manual handling such as lifting, carrying, and arranging objects, also pushing or pulling heavy objects. Application of force, high repetition, and awkward working posture are the physical risk factors of musculoskeletal injuries and exposure to these leads to a series of disorders.

AIM:
The study aimed to find out the prevalence of musculoskeletal injuries in salespersons.

SETTINGS AND DESIGN:
Stores selling sports products (Decathlon stores), cross-sectional study.

SUBJECTS AND METHODS:
This study was a cross-sectional analysis conducted over 6 months. Ethical clearance was obtained from the institutional ethics committee and the store committee for the study. A total of 100 salespersons working in stores selling sports products were included in the study. The participants were selected based on specific inclusion criteria, which included being between the ages of 18 and 45 years and having a minimum of 1 year of experience working as a salesperson. Demographic data and general characteristics of the participants working as salespersons were obtained, and later the Nordic Musculoskeletal Questionnaire was administered to the participants through online forms. The responses were recorded, and descriptive analysis was done using SPSS software.

RESULTS:
In this study involving 100 participants, it was found that 87% of them experienced musculoskeletal injuries, leading to pain and discomfort. The most common areas affected were the low back (61%), ankles/feet (42%), knees (36%), and neck (19%).

CONCLUSION:
There is a high prevalence of musculoskeletal injuries among salespersons. Low back was the region most affected, followed by ankles/feet, knees, and neck.
IoT Challenges, Solution Framework And Implementation
Authors: Mittal Pooja , Sharma Monika , Nath Thulal Amit 
Published: August 2023

The Internet of Things is a vast growing technology that is almost applicable in all fields and has simplified our lives. IOT is being used everywhere these days, including in smart cities, smart environments, security, smart business processes, smart agriculture, healthcare, and many more fields. Being able to cover various fields, is very challenging and presents various problems. This paper highlights IOT components, building blocks, enabling technologies, characteristics, applications, and products, as well as the issues encountered by them and lastly their causes. It brings forward seven steps of proposed solutions for handling and eliminating the problems encountered by almost all IOT devices and applications. The main aim of this paper is to provide the solution for all the issues which have been talked about for years but could not be able to resolve.
Dried Serum Samples for Antibody Detection in Arthropod-Borne Virus Infections Are an Effective Alternative to Serum Samples
Authors: Würsch Daniela , Rojas-Montes Othon , Maldonado-Rodríguez Angélica , Sevilla-Reyes Edgar , Cevallos Ana María , Sánchez-Burgos Gilma , Chávez-Negrete Adolfo , Lira Rosalía 
Published: August 2023

ABSTRACT.
The disease burden of arthropod-borne infections is particularly high in low- and middle-income countries, where the availability of resources for surveillance and testing is limited. The lack of local infrastructure demands that biological samples be sent to central laboratories by refrigerated transport, which increases costs and the risk of sample degradation. Dried blood spot samples are an alternative for ensuring sample integrity during transportation and storage. They can be used for the detection of nucleic acids and proteins, such as antigens or antibodies. Here, we compared anti-chikungunya IgM, anti-dengue IgM, anti-dengue IgG, and anti-Zika IgG detection between paired serum and dried serum samples (DSSs); the agreement between results was found to be 90.6%, 94.1%, 85.9%, and 95.5%, respectively, indicating a strong correlation. Our results suggest that DSSs provide a reliable alternative for detection of specific antibodies in arthropod-borne infections.
A GRAMMATICA PHILOSOPHICA DA LINGUA PORTUGUEZA, DE SOARES BARBOSA, COMO PROPOSTA A UMA GRAMÁTICA UNIVERSAL DA LÍNGUA PORTUGUESA / THE PHILOSOPHICAL GRAMMAR OF THE PORTUGUESE LANGUAGE BY SOARES BARBOSA AS A PROPOSAL FOR A UNIVERSAL GRAMMAR OF THE PORTUGUESE LANGUAGE
Authors: Hanna Adel Malek , De Lima Adriana Alves 
Published: August 2023

<p>O presente artigo propõe desenvolver um estudo sobre a <em>Grammatica Philosophica da Lingua Portugueza</em>, de Jerônimo Soares Barbosa, enquanto protótipo de uma Gramática Gerativa Portuguesa. O objetivo é averiguar se a Grammatica de Soares Barbosa pode se vista como sendo uma Protogramática Gerativa, a julgar pelas características que permeiam a obra enquanto proposta de uma Gramática Geral/Universal. O método adotado foi qualitativo, com levantamento bibliográfico e documental, de natureza básica, com pesquisa exploratória sobre a obra em questão e sobre a Gramática Gerativa de Chomsky. No decorrer da pesquisa fizemos um levantamento sobre a representação da linguagem que antecedeu a escrita, passando por uma breve explanação sobre os primeiros gramáticos para então trabalhar com a <em>Grammatica Philosophica da Lingua Portugueza</em>, como meio de conhecer e detectar algumas de suas características principais no quesito da Gramática Universal. Na sequência, a pesquisa se voltou para a Gramática Gerativa, buscando fazer um levantamento de suas características e particularidades no que se refere à Gramática Universal, para, então fazer um estudo mais aprofundado sobre a parte Lógica da Grammatica de Soares Barbosa, correspondendo aos livros III e IV dessa obra. Após o percurso feito, notou-se que a obra de Soares Barbosa apresenta elementos inovadores e relação as outras gramáticas de base jesuítica. Esses aspectos inovadores estão no desenvolvimento dos livros I e II que tratam da Orthoepia e da Orthografia, mas que não foram contemplados com um estudo mais aprofundado sobre eles. E a proposta de uma Gramática Geral se concretizou a partir da argumentação proposta por Soares Barbosa, tomando como princípio básico elementos gramaticais que pertencem ao campo psíquico e comum a todos os seres humanos, independente da língua, do país em que vive.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0001/a.php" alt="Hit counter" /></p>
Relationship of Identity and Commitment Towards Faculty's Performance of Laguna State Polytechnic University Faculty, Philippines
Authors: Pinuela Freddie S. 
Published: August 2023

The relevance of curriculum in supporting high levels of learning and the articulation and promotion of comprehensive development-relevant education was stressed in Sustainable Development Goal Four (SDG 4). The study used a quantitative research design employing a descriptive-correlational approach. Forty (40) faculty members of Laguna State Polytechnic University (LSPU) from the College of Industrial Technology (CIT) participated in the study, where purposive sampling was used in choosing the respondents. JASP software was used in analyzing the data in the study. Based on the findings, The relationship between identity, commitment, and faculty teaching performance is highly valued at LSPU. Furthermore, there is no substantial association between teachers' professional identities and commitment to instructors' performance. Thus, teachers' performance should be prioritized because it impacts the school's long-term success. Future researchers may use a qualitative research design in a different setting.