bluuebunny/crossref_metadata_2025_split huggingface dataset:
P62/SQSTM1 binds with claudin-2 to target for selective autophagy in stressed intestinal epithelium
Authors: Ahmad Rizwan , Kumar Balawant , Tamang Raju Lama , Talmon Geoffrey A. , Dhawan Punita , Singh Amar B. 
Published: July 2023

AbstractImpaired autophagy promotes Inflammatory Bowel Disease (IBD). Claudin-2 is upregulated in IBD however its role in the pathobiology remains uncertain due to its complex regulation, including by autophagy. Irrespective, claudin-2 expression protects mice from DSS colitis. This study was undertaken to examine if an interplay between autophagy and claudin-2 protects from colitis and associated epithelial injury. Crypt culture and intestinal epithelial cells (IECs) are subjected to stress, including starvation or DSS, the chemical that induces colitis in-vivo. Autophagy flux, cell survival, co-immunoprecipitation, proximity ligation assay, and gene mutational studies are performed. These studies reveal that under colitis/stress conditions, claudin-2 undergoes polyubiquitination and P62/SQSTM1-assisted degradation through autophagy. Inhibiting autophagy-mediated claudin-2 degradation promotes cell death and thus suggest that claudin-2 degradation promotes autophagy flux to promote cell survival. Overall, these data inform for the previously undescribed role for claudin-2 in facilitating IECs survival under stress conditions, which can be harnessed for therapeutic advantages.
Federated benchmarking of medical artificial intelligence with MedPerf
Authors: Karargyris Alexandros , Umeton Renato , Sheller Micah J. , Aristizabal Alejandro , George Johnu , Wuest Anna , Pati Sarthak , Kassem Hasan , Zenk Maximilian , Baid Ujjwal , Narayana Moorthy Prakash , Chowdhury Alexander , Guo Junyi , Nalawade Sahil , Rosenthal Jacob , Kanter David , Xenochristou Maria , Beutel Daniel J. , Chung Verena , Bergquist Timothy , Eddy James , Abid Abubakar , Tunstall Lewis , Sanseviero Omar , Dimitriadis Dimitrios , Qian Yiming , Xu Xinxing , Liu Yong , Goh Rick Siow Mong , Bala Srini , Bittorf Victor , Puchala Sreekar Reddy , Ricciuti Biagio , Samineni Soujanya , Sengupta Eshna , Chaudhari Akshay , Coleman Cody , Desinghu Bala , Diamos Gregory , Dutta Debo , Feddema Diane , Fursin Grigori , Huang Xinyuan , Kashyap Satyananda , Lane Nicholas , Mallick Indranil ,   FeTS Consortium,   BraTS-2020 Consortium,   AI4SafeChole Consortium, Mascagni Pietro , Mehta Virendra , Moraes Cassiano Ferro , Natarajan Vivek , Nikolov Nikola , Padoy Nicolas , Pekhimenko Gennady , Reddi Vijay Janapa , Reina G. Anthony , Ribalta Pablo , Singh Abhishek , Thiagarajan Jayaraman J. , Albrecht Jacob , Wolf Thomas , Miller Geralyn , Fu Huazhu , Shah Prashant , Xu Daguang , Yadav Poonam , Talby David , Awad Mark M. , Howard Jeremy P. , Rosenthal Michael , Marchionni Luigi , Loda Massimo , Johnson Jason M. , Bakas Spyridon , Mattson Peter 
Published: July 2023

AbstractMedical artificial intelligence (AI) has tremendous potential to advance healthcare by supporting and contributing to the evidence-based practice of medicine, personalizing patient treatment, reducing costs, and improving both healthcare provider and patient experience. Unlocking this potential requires systematic, quantitative evaluation of the performance of medical AI models on large-scale, heterogeneous data capturing diverse patient populations. Here, to meet this need, we introduce MedPerf, an open platform for benchmarking AI models in the medical domain. MedPerf focuses on enabling federated evaluation of AI models, by securely distributing them to different facilities, such as healthcare organizations. This process of bringing the model to the data empowers each facility to assess and verify the performance of AI models in an efficient and human-supervised process, while prioritizing privacy. We describe the current challenges healthcare and AI communities face, the need for an open platform, the design philosophy of MedPerf, its current implementation status and real-world deployment, our roadmap and, importantly, the use of MedPerf with multiple international institutions within cloud-based technology and on-premises scenarios. Finally, we welcome new contributions by researchers and organizations to further strengthen MedPerf as an open benchmarking platform.
Developmental Language Disorder and Writing: A Scoping Review From Childhood to Adulthood
Authors: Tucci Alexander , Choi Elizabeth 
Published: July 2023

Purpose:The purpose of this study was to conduct a scoping review of literature focused on the effects of developmental language disorder (DLD) on writing skills across the life span to highlight gaps in our knowledge of how to support writing for this population.Method:We adopted the five-step framework for conducting scoping reviews outlined by Arksey and O'Malley (2005) to identify literature focused on writing outcomes for individuals with DLD in childhood, adolescence, and adulthood.Results:Seventy-two studies from 1991 to 2022 met review criteria. Results indicated that spelling may be an area of relative weakness for individuals with DLD across the life span. Children and adolescents with DLD also may have relative difficulty with grammar, organization, cohesion, and length of written output. Research on the writing skills of adults with DLD is too sparse to draw broad conclusions about the writing skills of this subset of the population with DLD.Conclusions:Overall, research into the writing skills of individuals with DLD is limited, and more information is needed to inform functional evidence-based approaches to assessment and intervention of writing for those with DLD from childhood through adulthood. Additionally, more focus on electronic writing in research is needed, as only two studies included in this review examined typed writing in any form. Results of this review also indicate a need for systematic, uniform approaches to defining and measuring writing skills for those who experience language difficulties.Supplemental Material:https://doi.org/10.23641/asha.23596797
Adapting Curricula for Children With Language Comprehension Deficits
Authors: Bridges Mindy S. , Curran Maura , Neal Corinne , Piasta Shayne , Fleming Kandace , Hogan Tiffany 
Published: July 2023

Purpose:
We will describe how a multisite research team adapted a language-focused curriculum to be used in a scale-up project. Specifically, we identified underlying principles to modify a Tier 1 whole-classroom language comprehension–focused curriculum to be used as a Tier 2 small-group curriculum with children identified as at risk for low language comprehension, including children with developmental language disorder (DLD).

Method:
We discuss how researchers used the following five guiding principles to adapt a curriculum for children at risk for low language comprehension, including children with DLD: (a) increased and ongoing professional development, (b) simplification of language input, (c) increased scaffolding, (d) attention to distributed practice, and (e) materials to support diversity and inclusion.

Results:
We used these guiding principles to modify a popular language-based curriculum used in schools across the country.

Conclusion:
This clinical focus article showcases how guiding principles and frameworks for adaptation, within implementation science, can serve as a guidepost for speech-language pathologists and other educators who are adapting or scaling up a curriculum or intervention that was not designed for their target population.
Analysis of the association between glomerular filtration rate, proteinuria and metabolic syndrome in chronic kidney patients based on longitudinal data
Authors: Guo Li , Guo Shanshan , Gong Youlan , Li Jing , Li Jiandong 
Published: July 2023

AbstractChronic kidney disease (CKD) is a group of chronic diseases caused by kidney damage from multiple causes. Metabolic syndrome (MS) manifests as dysfunction of endothelial cells and chronic functional inflammatory states, and may be involved in pathological changes related to renal impairment. Based on longitudinal data analysis of the association between estimated glomerular filtration rate (eGFR), proteinuria and MS in patients with CKD, this study aims to provide new ideas for the pathophysiological mechanism of CKD and a theoretical basis for the early prevention and effective intervention of MS‐related kidney damage. A total of 126 patients with CKD were divided into non‐MS group and MS group. According to the eGFR level, 126 patients with CKD were divided into G1 group, G2 group, G3a group, G3b group, G4 group and G5 group. Serum markers such as eGFR, urine protein, and triglycerides (TG) were collected. The correlation between eGFR, urine protein and MS‐related indexes was analysed, and the risk factors affecting CKD complicated by MS were analysed. In patients with CKD, the levels of urine protein, abdominal circumference, TG, systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting blood glucose (FPG) were increased with the course of the disease, but the levels of eGFR and high density lipoprotein (HDL‐C) were decreased (p < 0.05). Abdominal circumference, TG, SBP, DBP, FP were significantly negatively correlated with eGFR, but HDL‐C was positively correlated with eGFR (p < 0.05). Diabetes, hyperlipidemia, UA, and SBP were independent risk factors affecting CKD complicated MS, and eGFR were independent protective factors (p < 0.05). The combination of diabetes, hyperlipidemia, UA, SBP, and eGFR exhibited higher prediction value for the CKD patients complicated by MS. There was a certain correlation between between MS components with eGFR and urinary protein in patients with CKD. The early intervention treatment of MS was helpful in delaying the development of CKD and reducing proteinuria.
Binary star population of the Sculptor dwarf galaxy
Authors: Arroyo-Polonio José María , Battaglia Giuseppina , Thomas Guillaume F. , Irwin Michael J. , McConnachie Alan W. , Tolstoy Eline 
Published: July 2023

Aims. We aim to compute the binary fraction of “classical” dwarf spheroidal galaxies (dSphs) that are satellites of the Milky Way (MW). This value can offer insights into the binary fraction in environments that are less dense and more metal-poor than our own galaxy. Additionally, knowledge of the binary fraction in dwarf galaxies is important with respect to avoiding overestimations of their dark matter content, inferred from stellar kinematics.
Methods. We refined an existing method from the literature, placing an emphasis on providing robust uncertainties on the value of the binary fraction. We applied this modified method to a VLT/FLAMES dataset for Sculptor, specifically acquired for the purpose of velocity monitoring of individual stars, as well as to literature datasets for other six MW “classical” dSphs. In all cases, the targeted stars were mainly red giant branch stars, with expected masses of around 0.8 M⊙. The VLT/FLAMES dataset offers the most precise binary fractions compared to literature datasets, due to its time baseline of 12 yr, along with at least nine repeated observations for each star.
Results. We found that the binary fraction of Sculptor is 0.55−0.19+0.17. We find that it is important to take into account the Roche lobe overflow for constraining the period distribution of binary stars. In contrast to what has recently been proposed in the literature, our analysis indicates that there is no evidence to support varying the properties of the binary stellar population or their deviations from those established for the solar neighborhood, based on the sample of MW dSphs analyzed here.
Serum Progranulin Levels and Disease Activity in Patients with Axial
Spondyloarthritis
Authors: Mercan Irem , Oktayoglu Pelin , Mete Nuriye , Caglayan Mehmet 
Published: July 2023

Abstract
Background Axial spondyloarthritides (ax-SpA) are a group of chronic
systemic diseases of unknown aetiology, affecting mostly young men, with common
features such as inflammatory low back pain, axial skeletal involvement,
sacroiliitis, and association with HLA-B27. Inflammatory cytokines, mainly
TNF-α, play a role in its aetiopathogenesis. Progranulin (PGRN) is
thought to be an anti-inflammatory molecule that acts through the TNF-α
pathway. In our study, we aimed to investigate the relationship between serum
PGRN levels and disease activity in patients with AS.
Material and Methods Forty-five patients between the ages of 18 and 65 who
were classified as having ax-SpA according to ASAS classification criteria were
included in our study. Forty-five individuals between the ages of 18 and 65 who
did not have pregnancy or lactation status, no acute or chronic infection and no
malignancy or rheumatic disease were included as the healthy control group. In
addition, BASDAI, BASFI, BASMI, ASDAS-CRP, ESR and CRP levels were recorded in
the patient group to determine the laboratory and clinical findings of patients
with ax-SpA.
Results Mean serum progranulin levels were higher in axial SpA patients
compared with the control group (5156.72±1274.34 vs.
4836.50±1422.10), but this result was not statistically significant
(p=0.275). Serum progranulin levels were negatively correlated with ESR
(p=0.031) but ASDAS-CRP (p=0.407) and BASDAI (p=0.297)
values were not correlated with the progranulin levels.
Conclusion Although we found a negative correlation between progranulin
and ESR, we did not find any association between progranulin and disease
activity in patients with axSpA. There is a need for new and larger studies to
be conducted with a higher number of participants in this patient group and to
measure serum PGRN levels as well as antibodies against PGRN.
Prognostic Value of hsa_circ_0007615 in Epithelial Ovarian Cancer and
its Regulatory Effect on Tumor Progression
Authors: Wei Wei , Wang Ning , Lin Lin 
Published: July 2023

AbstractThis study aimed to interrogate the functional and clinical significance of
hsa_circ_0007615 in epithelial ovarian cancer (EOC). GSE192410 was screened for
upregulated circRNAs in ovarian cancer. The expression levels of
hsa_circ_0007615 were evaluated in a patient cohort comprising 113 EOC tissues
and matched normal tissues. Subsequently, the prognostic value was confirmed by
the relevance of hsa_circ_0007615 with clinical parameters, Kaplan–Meier
analysis and Cox proportional risk model. Cell functional analyses were
performed in EOC cell lines using a cell proliferation kit, transwell and cell
death kit. Our data revealed that hsa_circ_0007615 was significantly upregulated
in EOC tissues and cell lines, compared with normal ones. Multivariate survival
analysis revealed that hsa_circ_0007615 emerged as an independent risk factor
for overall survival and recurrence of EOC patients. Knockdown of
hsa_circ_0007615 in EOC cells led to the blocking of cell proliferation,
migration and invasion, but an increase of cell death presenting as ferroptosis.
Tumor suppressive effects of hsa_circ_0007615 knockdown can be abolished by
miR-874-3p inhibition. TUBB3 was a targeting gene of miR-874-3p.
Hsa_circ_0007615 has the functional and clinical significance of EOC.
Mechanistically, hsa_circ_0007615 may contribute to EOC by sponging miR-874-3p
and moderating TUBB3.
Congenital Internal Jugular Phlebectasia: An Anomaly Still Poorly Recognized
Authors: Raffaele Alessandro , Gazzaneo Marta , Romano Piero , Prevedoni Gorone Maria Sole , Avolio Luigi 
Published: July 2023

AbstractCongenital internal jugular phlebectasia (CIJP) is a rare condition characterized by congenital dilatation of the vein without tortuosity that becomes more evident during straining as a lateral neck mass. CIJP often remains undiagnosed from a few months to several years after the onset of the swelling. It is frequently asymptomatic although symptomatic cases have been occasionally reported. We present the case of a healthy 7-year-old boy with a lateral neck mass, triggered by the Valsalva maneuver. Neck ultrasound (US) showed right internal jugular axial ectasia, increasing during the Valsalva maneuver; contrast computed tomography (CT) scan confirmed a fusiform dilatation of the right internal jugular vein. Due to the lack of symptoms, we treated our patient conservatively. At 5 years of follow-up, the patient is still asymptomatic, with no evidence of complications or thrombosis. Due to its self-limiting nature, treatment for asymptomatic cases of CIJP should be conservative, providing a follow-up with both clinical and US annual evaluations.
Visible-Light-Driven Denitrogenative C–C Bond Formation and Oxidative Difunctionalization of Vinyl Azides
Authors: Majee Adinath , Sardar Santosh Sing , De Aramita , Pal Satyajit , Sarkar Subhankar , Santra Sougata , Zyryanov Grigory V. 
Published: July 2023

AbstractA newer synthetic protocol has been developed to synthesize α-oxyalkyl ketones from vinyl azides under transition-metal-free reaction conditions. The reaction proceeds in the presence of organic photoredox catalyst rose bengal, an oxidant tert-butyl hydroperoxide (TBHP), and ethers. A broad range of substituted vinyl azides were found to react smoothly upon visible-light irradiation, which readily furnished the related products. Several control experiments have been done to suggest a probable mechanism. The process is initiated by radical addition to vinyl azide, which triggers a cascade fragmentation mechanism driven by the loss of dinitrogen and the stabilized ether radical ultimately produces the α-oxyalkyl ketones. This method provides a simple, mild, straight forward, novel paradigm to prepare α-oxyalkyl ketones.
Iron-Catalyzed Oxidative Decarboxylation of Oxamic Acids: A Safe and Efficient Photochemical Route to Urethanes
Authors: Landais Yannick , Kurtay Gülbin , Lusseau Jonathan , Robert Frédéric 
Published: July 2023

AbstractThis study presents a facile method for synthesizing urethanes through the photocatalyzed oxidative decarboxylation of oxamic acids. The process involves the formation of an isocyanate in situ from an oxamic acid under blue-light irradiation (427 nm) in the presence of ferrocene as a photocatalyst, 2-picolinic acid as a ligand, and potassium bromate as an oxidant. The one-pot procedure effectively avoids the need for separation, purification, and storage of carcinogenic isocyanates, making it a safer and more practical method for obtaining target urethanes from easily accessible starting materials.
Measuring the observer (Hawthorne) effect on adenoma detection rates
Authors: Taghiakbari Mahsa , Coman Diana Elena , Takla Mark , Barkun Alan , Bouin Mickael , Bouchard Simon , Deslandres Eric , Sidani Sacha , von Renteln Daniel 
Published: July 2023

Abstract
Background and study aims An independent observer can improve procedural quality. We evaluated the impact of the observer (Hawthorne effect) on important quality metrics during colonoscopies.
Patients and Methods In a single-center comparative study, consecutive patients undergoing routine screening or diagnostic colonoscopy were prospectively enrolled. In the index group, all procedural steps and quality metrics were observed and documented, and the procedure was video recorded by an independent research assistant. In the reference group, colonoscopies were performed without independent observation. Colonoscopy quality metrics such as polyp, adenoma, serrated lesions, and advanced adenoma detection rates (PDR, ADR, SLDR, AADR) were compared. The probabilities of increased quality metrics were evaluated through regression analyses weighted by the inversed probability of observation during the procedure.
Results We included 327 index individuals and 360 referents in
the final analyses. The index group had significantly higher PDRs (62.4% vs. 53.1%, P=0.02) and ADRs (39.4% vs. 28.3%, P=0.002)
compared with the reference group. The SLDR and AADR were not significantly increased. After
adjusting for potential confounders, the ADR and SLDR were 50% (relative risk [RR] 1.51; 95%,
CI 1.05–2.17) and more than twofold (RR 2.17; 95%, CI 1.05–4.47) more likely to be higher in
the index group than in the reference group.
Conclusions The presence of an independent observer documenting colonoscopy quality metrics and video recording the colonoscopy resulted in a significant increase in ADR and other quality metrics. The Hawthorne effect should be considered an alternative strategy to advanced devices to improve colonoscopy quality in practice.
Full-thickness resection device for management of lesions involving the appendiceal orifice: Systematic review and meta-analysis
Authors: Obri Mark , Ichkhanian Yervant , Brown Patrick , Almajed Mohamed Ramzi , Nimri Faisal , Taha Ashraf , Agha Yasmine , Jesse Michelle , Singla Sumit , Piraka Cyrus , Zuchelli Tobias E. 
Published: July 2023

Abstract
Background and study aims Endoscopic resection of lesions involving the appendiceal orifice is technically challenging and is commonly referred for surgical resection. However, post-resection appendicitis is a concern. Many studies have varying rates of post-procedure appendicitis. We aim to report the rate of post-resection appendicitis by performing a systematic review and meta-analysis.
Methods Studies that involved the use of a full-thickness resection device (FTRD) for management of appendiceal polyps were included. The primary outcome was appendicitis after FTRD and a subgroup analysis was performed on studies that only included FTRD performed at the appendiceal orifice.
Results Appendicitis was encountered in 15% (95%CI: [11–21]) of the patients with 61% (95% CI: [44–76]) requiring surgical management. Pooled rates of technical success, histologic FTR, and histologic R0 resection in this sub-group (n=123) were 92% (95% CI: [85–96]), 98% (95% CI: [93–100]), and 72% (95% CI: [64–84%]), respectively. Post-resection histopathological evaluation revealed a mean resected specimen size of 16.8 ± 5.4 mm, with non-neoplastic pathology in 9 (7%), adenomas in 103 (84%), adenomas + high-grade dysplasia (HGD) in nine (7%), and adenocarcinoma in two (2%). The pooled rate for non-appendicitis-related surgical management (technical failure and/or high-risk lesions) was 11 % (CI: 7–17).
Conclusions FTRD appears to be an effective method for managing appendiceal lesions. However, appendicitis post-resection occurs in a non-trivial number of patients and the R0 resection rate in appendiceal lesions is only 72%. Therefore, caution should be employed in the use of this technique, considering the relative risks of surgical intervention in each patient.
Comparison of guidewires for successful cannulation of biliary stenosis and targeting of biliary branches in ERCP
Authors: Kobayashi Masanori , Katsuda Hiromune , Ohtsuka Kazuo , Okamoto Ryuichi 
Published: July 2023

Abstract
Background and study aims Guidewires play a crucial role in endoscopic retrograde cholangiopancreatography. The ability to pass through stenosis, and the ability to seek the desired biliary branch are particularly important. In this study, we aimed to compare these specific abilities in various guidewires by using a bile duct model.
Patients and methods Seven 0.025-inch angle-type guidewires
(VisiGlide2, Fielder 25, EndoSelector, NaviPro, Jagwire Plus, RevoWave DualMaster, and J-WIRE
prologue ST) were evaluated. To compare these, a bile duct silicone model was prepared. The
time from the entry of the guidewire into the common bile duct with the stenosis to the
emergence of the guidewire from the common bile duct after reaching two target intrahepatic
bile duct branches was measured.
Results VisiGlide 2 and Fielder 25 were the fastest guidewires, whereas Jagwire Plus was the slowest.
Conclusions In this study, a guidewire with a tip deflection height of approximately 9 mm and a hydrophilic coating length of 7 to 8 cm achieved the fastest completion time for the course. In clinical practice, it is important to consider the performance required in various scenarios and to select the most appropriate guidewire. The results of this model test, which focused on the time required to complete the course around the model, can serve as a foundation for guidewire selection. This method holds potential utility in future guidewire development.