bluuebunny/crossref_metadata_2025_split huggingface dataset:
An illuminating piece in the jigsaw of Hodgkin lymphoma risk stratification
Authors: Shankar Ananth , Bomanji Jamshed 
Published: March 2023

SummaryThe management strategy of classical Hodgkin lymphoma in children is focussed on maximising therapeutic efficacy while minimising treatment‐related toxicity via a risk‐adapted and response‐based approach. By using volumetric PET parameters, the report of Milgrom and her colleagues shows that combining pretreatment volumetric quantitative PET data with the early response assessment PET2 scan improved risk stratification in children with high‐risk classical Hodgkin lymphoma treated on the COG AHOD0831 trial.Commentary on: Milgrom et al. Baseline metabolic tumor burden improves risk stratification in Hodgkin lymphoma: A Children's Oncology Group Study. Br J Haematol 2023;201:1192–1199.
“I'm a man now”: Using Narrative Therapy to support an adult with Down syndrome transition to a new life
Authors: Lau‐Zhu Alex , Mann Judith 
Published: March 2023

AbstractBackgroundResidential transitions have long been recognised as challenging for people with learning disabilities and can be packed with problem stories. Narrative Therapy practices have the potential to centre the voice of people with learning disabilities; to enable alternative stories to be told; and to shine a light on their own and their support system's resources for change.MethodsColin, a 36‐year‐old man with Down syndrome and a learning disability, met with the first author for nine sessions. Narrative Therapy practices (also drawing on systemic ideas) were used, including the Tree of Life, Outsider Witness Practice, Therapeutic Documentation and Definitional Ceremony. Feedback from Colin and the staff team was gathered through qualitative and quantitative means.FindingsColin was keen to share his life stories and explored ideas about his “new life”, wanting to “stay strong” and “stay happy”. Staff noted an improvement in household stress and perceived ability to support Colin. An improvement in quality of life was also demonstrated with a self‐report questionnaire.ConclusionsBy acknowledging the power of language, narrative practices offer tools to help people with learning disabilities and their support system in making sense of and navigating important life transitions.
S2k‐Leitlinie – Merkelzellkarzinom – Update 2022
Authors: Becker Jürgen C. , Beer Ambros J. , DeTemple Viola K. , Eigentler Thomas , Flaig Michael J. , Gambichler Thilo , Grabbe Stephan , Höller Ulrike , Klumpp Bernhard , Lang Stephan , Pföhler Claudia , Posch Christian , Prasad Vikas , Schlattmann Peter , Schneider‐Burrus Sylke , Ter‐Nedden Jan , Terheyden Patrick , Thoms Kai , Vordermark Dirk , Ugurel Selma 
Published: March 2023

ZusammenfassungDas Merkelzellkarzinom (MCC, ICD‐O M8247/3) ist ein seltener, maligner, primärer Hauttumor mit epithelialer und neuroendokriner Differenzierung. Die Tumorzellen teilen viele morphologische, immunhistochemische und ultrastrukturelle Eigenschaften mit den Merkel‐Zellen der Haut. Die Ursprungszelle (cell of origin) des MCC ist dennoch unklar. Das MCC imponiert klinisch als ein rötlich bis violett farbiger kugeliger Tumor mit glatter glänzender Oberfläche und weicher bis prall‐elastischer Konsistenz, der in der Regel ein schnelles Wachstum aufweist. Spontane, häufig auch komplette Regressionen des Tumors werden beobachtet. Diese wahrscheinlich immunologisch‐vermittelten Regressionen erklären die Fälle, bei denen zum Zeitpunkt der Erstdiagnose nur Lymphknoten‐ oder Fernmetastasen gefunden werden und warum der Tumor auch in weit fortgeschrittenen Stadien sehr gut auf immunmodulierende Therapien anspricht. Aufgrund seiner Aggressivität, der in der Regel gegebenen Indikation zur Schildwächterlymphknotenbiopsie, der zu evaluierenden Indikation adjuvanter Therapien, sowie der Komplexität der notwendigen Diagnostik sollte das Vorgehen bereits bei Erstdiagnose durch ein interdisziplinäres Tumorboard festgelegt werden.
Biomechanische Eigenschaften transgener Haut nach lebensrettender Regeneration der Epidermis durch kombinierte Gen‐ und Stammzelltherapie
Authors: Yeni Burcu , Dermietzel Alexander , Varnava Charalampos , Wiebringhaus Philipp , Aitzetmueller Matthias , Klietz Marie‐Luise , Hirsch Tobias , Kueckelhaus Maximilian 
Published: March 2023

ZusammenfassungHintergrundIm Jahr 2017 beschrieben wir die erste lebensrettende Regeneration einer nahezu vollständigen Epidermis durch kombinierte Gen‐ und Stammzelltherapie. Kürzlich berichteten wir über eine ausgezeichnete Langzeitstabilität dieser transgenen Epidermis. Zur Charakterisierung der aus diesem experimentellen Ansatz resultierenden Hautqualität und ihrer potenziellen Anwendung bei anderen Erkrankungen berichten wir hier über die Langzeitergebnisse hinsichtlich der biomechanischen Eigenschaften der Haut.Patienten und MethodikEine detaillierte Analyse der biomechanischen Eigenschaften, einschließlich Hautelastizität, Anisotropie und Friktion, wurde an mehreren Körperstellen 24, 36 und 60 Monate nach der ersten Transplantation durchgeführt. Zunächst wurden die Körperstellen mit den stabilen nicht‐transgenen Bereichen verglichen. Im Weiteren erfolgte ein Vergleich mit einer Kontrollgruppe aus 13 hautgesunden Probanden. Die Messung von Hautelastizität, Anisotropie und Friktion erfolgte mit nichtinvasiven Messungen.ErgebnisseDie biomechanischen Hauteigenschaften der transgenen Epidermis zeigten ähnliche Ergebnisse im Vergleich zur verbleibenden nicht‐transgenen Haut und zur gesunden Kontrollgruppe. Die Hautelastizität zeigte vergleichbare Ergebnisse wie bei der Kontrollgruppe. Die Friktion der Haut nahm sowohl in den transgenen als auch in den nicht‐transgenen Bereichen im Vergleich zur Kontrollgruppe ab.SchlussfolgerungenDie neuartige kombinierte Gen‐ und Stammzelltherapie zeigt hervorragende funktionelle Langzeitergebnisse der vollständig regenerierten transgenen Epidermis. Wegen dieser Ergebnisse sollten weitere Anwendungen dieser Technologie, wie die Behandlung von Verbrennungen, Gegenstand zukünftiger Forschung sein.
Seborrhoische Keratosen
Authors: Barthelmann Sara , Butsch Florian , Lang Berenice M. , Stege Henner , Großmann Bernd , Schepler Hadrian , Grabbe Stephan 
Published: March 2023

ZusammenfassungDie seborrhoische Keratose (SK) ist der häufigste gutartige epidermale Tumor in der klinisch‐dermatologischen Praxis. Diese Übersicht fasst den Kenntnisstand zu Klinik, Histologie, Epidemiologie, Pathogenese und Therapie von SK zusammen. Anhand des klinischen und histologischen Bildes unterscheidet man verschiedene Typen der SK. Es wird vermutet, dass mehrere Faktoren, darunter das Alter, eine genetische Prädisposition und möglicherweise auch die Exposition gegenüber ultravioletter Strahlung mit der Entstehung der Tumoren in Verbindung stehen. Die Läsionen können an allen Körperregionen auftreten, mit Ausnahme der Handflächen und Fußsohlen, die häufigsten Stellen sind jedoch das Gesicht und der obere Rumpf. Die Diagnose erfolgt meistens klinisch, in manchen Fällen unter Zuhilfenahme eines Dermatoskops oder durch Biopsie. Viele Patienten bevorzugen es, SK aus kosmetischen Gründen zu entfernen, obwohl keine medizinische Indikation hierzu vorliegt. Bei den Behandlungsmöglichkeiten wird zwischen chirurgischen, chirurgisch‐destruierenden (Laser, Elektrodesikkation/‐kaustik, Kryotherapie) und topisch‐medikamentösen Verfahren unterschieden. Letztere sind aktuell in klinischer Entwicklung. Die Behandlung wird abhängig vom klinischen Bild und der Präferenz des Patienten individuell angepasst.
Dermatologische Bewertung von Hautveränderungen nach COVID‐19‐Impfung – eine monozentrische Studie in Deutschland
Authors: Wang Rosi , Mathes Sonja , Claussen Carla , Biedermann Tilo , Brockow Knut 
Published: March 2023

ZusammenfassungHintergrund und ZieleHautreaktionen nach COVID‐19‐Impfung werden in dieser Studie präzise mitsamt Schweregrad, Verlauf, Therapie, auslösender Impfstoffe, allergologischer Abklärung und der Verträglichkeit der Folgeimpfung untersucht.Patienten und Methodik83 Patienten wurden in dieser monozentrischen Studie an einer dermatologischen Universitätsklinik untersucht.ErgebnisseDie Manifestationen (n = 93) gliederten sich in Sofort‐Überempfindlichkeitsreaktionen angelehnt an Soforttypallergien (n = 51; 54,8%), verzögerte Überempfindlichkeitsreaktionen angelehnt an Spättypallergien (n = 10; 10,8%), chronisch‐entzündliche Hauterkrankungen (n = 13; 14,0%), Reaktivierung einer latenten Herpesvirusinfektion (Pityriasis rosea und Herpes zoster; n = 9; 9,7%) und „Sonstige“ (n = 10; 10,8%). Sowohl nicht vorbekannte Hautreaktionen (76,3%) – vorrangig Sofort‐Überempfindlichkeitsreaktionen oder verzögerte Überempfindlichkeitsreaktionen – als auch eine Verschlechterung einer vorbekannten Hauterkrankung (23,7%) – meist chronisch‐entzündliche Hauterkrankungen – traten auf. Meist entwickelten sie sich innerhalb der ersten Woche (72,8%) und initial nach der ersten Impfung (62,0%). In 83,9% der Fälle erfolgte eine Therapie; in 19,4% sogar eine stationäre Behandlung. Eine Folgeimpfung führte bei 48,8% zum Wiederauftreten der gleichen Reaktion. Persistierende Reaktionen bis zum Zeitpunkt der letzten Vorstellung fanden sich in 22,6%, primär bei chronisch‐entzündlichen Hauterkrankungen. Eine allergologische Diagnostik wurde bei 15 Patienten (18,1%) durchgeführt; und zeigte negative Resultate.SchlussfolgerungenEine durch COVID‐19‐Impfungen ausgelöste Aktivierung des Immunsystems kann insbesondere bei prädisponierten Patienten zu kutanen Reaktionen führen.
In Search of an Adequate Response to Pluralism: A Critical Analysis of Liberalism in Philosophy of Education
Authors: Wenneborg Emily G. 
Published: March 2023

AbstractNearly everyone recognizes the fact of deep pluralism: it is hard to deny that contemporary America is characterized by widespread diversity of beliefs, practices, and values. We disagree, not on this reality, but on the way we should respond to the pluralism around us. In this paper, Emily G. Wenneborg discusses one of the most common responses to pluralism in contemporary philosophy of education: autonomy‐based liberalism. She praises liberalism for its attempt to navigate certain tensions that accompany its approach to pluralism. At the same time, she raises several critiques of liberalism as a response to pluralism, particularly with regard to religious communities and belief systems. She suggests that trust provides a better framework than autonomy for educating in and for deep pluralism.
Status epilepticus prognosis following levetiracetam administration: Analysis of loading doses
Authors: Kuffer Ian , Novy Jan , Rossetti Andrea O. 
Published: March 2023

AbstractBackground and purposeRecommended loading doses of levetiracetam (LEV) for status epilepticus (SE) treatment have increased over time. However, this was not evidence‐based, and the benefit of the increase remains unclear. The effect of different LEV loading doses on SE prognosis was explored.MethodsThis is a retrospective analysis of an SE adult registry (January 2016–December 2021), including patients receiving LEV as a second‐line SE treatment. Patients were stratified according to LEV loading doses (threshold 35 mg/kg). Main outcomes were global mortality, LEV use as last SE treatment, and return to baseline conditions at discharge, exploring LEV as a dichotomized or continuous dose.ResultsAmong 202 patients, 44 received LEV at ≥35 mg/kg and 158 below it. Global mortality, adjusted for SE severity and potentially fatal aetiology, was more frequent in the high LEV dose group (27.2% vs. 17.1%, odds ratio 3.14, 95% confidence interval 1.23–8.06; p = 0.017), whilst LEV prescription as last treatment and return to baseline conditions were comparable. Considering continuous LEV dosages or mortality in ongoing SE, however, no outcome reached statistical significance.ConclusionsLower LEV loading doses do not seem to correlate with worse clinical outcome, challenging current guidelines. Further studies, ideally prospective, are needed on this topic.
Atrial fibrillation detection using Poincare geometry and heart beat intervals
Authors: Shrikanth Rao S. K. , Kolekar Maheshkumar H. , Martis Roshan Joy 
Published: March 2023

AbstractDetection of atrial fibrillation (AF) remains one of the major concerns in the field of medical research. AF is one of the main cause for stroke. AF is characterized by irregular heartbeats and absence of P waves in electrocardiogram (ECG) signal. In this article, we propose a method, combining Poincare plot derived and RR interval‐based features to classify given ECG signal into normal, AF and other rhythms. Classification and regression tree, K‐nearest neighbor, support vector machine, artificial neural network, ResNet18, convolutional neural network (CNN)‐long short term memory (LSTM) are implemented for classification of ECG signal. The class specific accuracies for the three rhythms are computed. Physionet challenge 2017 database is used for evaluation and testing of the developed algorithm. The database has 5154 normal, 771 AF, 2557 other rhythm and 46 noisy signals. Three Poincare derived features viz: SD1, SD2, and ratio of SD1 to SD2, three RR interval features viz: Mean stepping increment of RR interval, approximate entropy and sample entropy are computed and are given to classifiers. During fivefold cross‐validation, CNN‐LSTM classifier showed best result with class specific accuracy for normal of 96.65%, AF of 97.55%, other rhythms of 94.87%, overall accuracy of 96.17% and F1 score of 0.9589. The developed technique can bring change in conventional practice in AF diagnosis and can aid the physician as an assisted tool.
Energy optimization in path arbitrary wireless sensor network
Authors: Goud B. Harish , Shankar T. N. , Sah Basant , Aluvalu Rajanikanth 
Published: March 2023

AbstractA network of wireless sensors is a self‐infrastructure approach with many sensory nodes. The distributed sensory nodes communicate with each other via sensory points. In wireless sensor network (WSN), the sensory nodes collect information for healthcare, military and monitoring systems. Such networks require an exclusive arrangement of the nodes to challenge inherent limitations and energy deficiency. The conventional design of a communication system consumes more energy with high latency causing degraded performance. This study provided a machine learning‐based path optimization mechanism using the least energy resources in designing an effective wireless network system with enhanced three measures of network performance, including throughput, packet delivery efficiency and energy usage. The proposed methodology is validated through network simulation tools.
Experimental study and fretting fatigue life prediction in dovetail assembly considering stress–temperature nonlinear coupling effect
Authors: Sun Debin , Gao Qiang , Huo Junzhou 
Published: March 2023

AbstractAs a paramount failure form of dovetail assembly, high‐temperature fretting fatigue seriously restricts the actual service life. Aiming at the problem of fretting fatigue life prediction of dovetail assembly of the aero‐engine compressor under the coexistence of stress and high temperature, based on D‐M contact theory and continuum damage mechanics theory, a fretting fatigue life prediction model considering stress–temperature nonlinear coupling effect is proposed in this paper by, respectively, introducing the fretting fatigue stress σfretting and the high‐temperature influence factor λ. Meanwhile, the judgment criterion of fretting fatigue crack initiation and failure is raised based on the strain–displacement method, and the fretting fatigue test is designed and carried out for experimental verification. The results show that the proposed fretting fatigue life prediction model has high life prediction ability, whose life prediction results are within ±1.7 times the error band, which can provide a theoretical reference for the structural design optimization and damage tolerance design of dovetail assembly.
Examining talent attraction and retention in small and medium‐sized cities: Where do universities fit in?
Authors: Osutei Nene , Kim Jae Hong 
Published: March 2023

AbstractAs universities have become more integrated into their communities and regions, their host cities have become locations of choice for the highly educated facilitating increased innovation and productivity rates in several locales. Recent transitions toward knowledge‐driven economies have also intensified growing geographic divides along the lines of education and raised concerns about the possibility of brain drain in a growing number of cities/regions. This study examines the changing geography of highly educated individuals (2000–2017) with a focus on small and medium‐sized U.S. metropolitan areas with and without research universities. Results indicate the continuing trend of divergence among regions, but research universities are found to complement (the lack of) talent agglomeration and generate spatial spillovers beyond the county boundaries.
Let's enjoy the heated “Debate Forum” (Gekiron Colosseo) at Makuhari Messe: A report of the 45th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2022)
Authors: Fukagawa Tatsuo 
Published: March 2023

AbstractThe 45th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2022) was held at Makuhari Messe in Chiba Prefecture from November 30 to December 2, 2022. We decided to make MBSJ2022 as the place for heated discussion and organized the meeting with the theme for MBSJ2022, heated “Debate Forum” (Gekiron Colosseo in Japanese). We had more than 6000 participants, and we believe that the meeting was finally ended in great success, as approximately 80% of survey respondents were generally satisfied with MBSJ2022 (https://www.mbsj.jp/meetings/annual/2022/enq.html). To implement the heated “Debate Forum,” we carried out many new projects; introduction of graphic abstracts, “Science Pitch,” “Meet My Hero/Heroine,” MBSJ‐ASCB‐EMBO joint sessions, a solo exhibition of Grant‐in‐Aid applications, a theme song, live classical music, elaborate photo booths, and a compact guide map, all together enabled close interaction among the participants. For the implementation of these unprecedented projects, here, I would like to summarize how we organized this meeting and our intentions.
Long‐term thermal stability of Li4TiO4–Li2TiO3 core–shell breeding pebbles under continuous heating in H2/Ar atmosphere
Authors: Chen Ruichong , Ipponsugi Akito , Oyama Ran , Qi Jianqi , Wang Haomin , Huang Zhangyi , Guo Hao , Lu Tiecheng , Feng Wei , Katayama Kazunari 
Published: March 2023

AbstractThe long‐term thermal stability of tritium breeding materials during service is a key factor to ensure efficient tritium release. In this study, the long‐term thermal stability of advanced Li4TiO4–Li2TiO3 core–shell breeding pebbles under continuous heating in 1%H2/Ar at 900°C was investigated for the first time. The results show that this core–shell material loses 3.4% Li mass after heating for 30 days, resulting in a reduction in Li density to .415 g/cm3, which is still significantly higher than other breeding materials. The moisture in the sample bed will determine the form of Li volatilization and thus affect the rate of Li mass loss. The core–shell pebbles maintain favorable phase stability during long‐term heating, and the grain sizes of the Li2TO3 shell and Li4TiO4 core after 30 days of heating are 6.5 ± 1.5 and 6.9 ± 2.5 μm, respectively. Moreover, the samples did not crack or collapse during long‐term heating and still had a satisfactory crushing strength of 37.61 ± 7.13 N after 30 days of heating. Overall, the high Li density and good thermal stability during long‐term heating demonstrate that the Li4TiO4–Li2TiO3 core–shell breeding pebbles are a very reliable tritium breeding material for long‐term service under harsh operating conditions.
Treatment recalcitrant cases of tinea corporis/cruris caused by T. mentagrophytes – interdigitale complex with mutations in ERG11 ERG 3, ERG4, MDR1 MFS genes & SQLE and their potential implications
Authors: Bhattacharyya Anamika , Sadhasivam Suresh , Sinha Mau , Gupta Swati , Saini Swamini , Singh Himanshi , Khurana Ananta , Sachdeva Soumya , Sardana Kabir , Ghosh Shamik 
Published: March 2023

AbstractBackgroundRecalcitrant dermatophyte infections are being reported from various parts of the world due to varied causes including strain variation, steroid misuse, SQLE mutations, and variable quality of itraconazole pellet formulations. The oral drug preferred in endemic areas is itraconazole, to which MIC levels remain low, and clinical failures to itraconazole reported defy a sound scientific explanation.ObjectivesThe objective of the study was to conduct a proteomic and genomic analysis on isolates from therapeutically recalcitrant case with isolation of gene mutations and enzymatic abnormalities to explain azole failures.MethodsTrichophyton mentagrophyte interdigitale complex strains were isolated from seven clinically non‐responding tinea corporis/cruris patients, who had failed a sequential course of 6 weeks of terbinafine 250 mg QD and itraconazole 100 mg BID. After AFST 1 strain, KA01 with high MIC to most drugs was characterized using whole genome sequencing, comparative proteomic profiling, and total sterol quantification.ResultsSterol quantification showed that the standard strain of Trichophyton mentagrophytes (MTCC‐7687) had half the ergosterol content than the resistant KA01 strain. Genomic analysis revealed mutations in SQLE, ERG4, ERG11, MDR1, MFS genes, and a novel ERG3 mutation. Proteomic analysis established the aberrant expression of acetyl Co‐A transferase in the resistant strain and upregulation of thioredoxin reductase and peroxiredoxin.ConclusionOur findings demonstrate possible reasons for multidrug resistance in the prevalent strain with mutations in genes that predict terbinafine (SQLE) and azole actions (ERG4, ERG11, ERG3) apart from efflux pumps (MDR1, MFS) that can explain multidrug clinical failures.
COVID‐19 infection in nursing staff: A cohort study
Authors: Nogueira Lilia de Souza , Poveda Vanessa de Brito , Lemos Cassiane de Santana , Bruna Camila Quartim de Moraes , Moura Bruna Roberta Siqueira 
Published: March 2023

AbstractAimThis study aims to identify the working conditions of Brazilian nursing professionals and the risk factors for these professionals to become infected by coronavirus disease.BackgroundUnderstanding the factors that affected nursing professionals during the pandemic can support better nursing management.DesignThis is a quantitative, cross‐sectional survey study.MethodsData collection was carried out between February and March 2022 in Brazil. All nursing professionals registered in the national database received by e‐mail the study instrument with the data collection variables: professionals' sociodemographic and comorbid, professional and institutional characteristics, and professionals' health conditions and disease‐related aspects for COVID‐19.ResultsFour thousand eight hundred sixty‐two nursing professionals reported a lack of personal protective equipment for patient care, and 4424 were infected by coronavirus disease. The risk factors to become infected were having cardiovascular disease, being under 60 years of age, living in the northern region, using public transportation, working in a hospital, an emergency department or reference institution for COVID‐19, living with an infected person and lack of respirators or waterproof aprons.ConclusionMultiple risk factors for infection with SARS‐CoV‐2 were demonstrated for the nursing professionals during the pandemic, highlighting current and future pandemics factors that are modifiable in a worthwhile time frame to minimize nurses' infection risks, such as inadequate working conditions associated with lack of essential personal protective equipment.