bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mối liên quan giữa đa hình đơn gen IL-17F RS763780, IL-17RA RS4819554 VÀ HLA-CW6 trên bệnh vảy nến thông thường ở Việt Nam
Authors: Nhi Phạm Thị Uyển , Thường Nguyễn Văn , Hào Nguyễn Trọng , Vũ Hoàng Anh , Trâm Dương Bích 
Published: January 2023

Vảy nến là bệnh viêm mạn tính, yếu tố di truyền đóng góp 30% trong cơ chế bệnh sinh, vì vậy xác định các dấu ấn sinh học giúp dự đoán đáp ứng điều trị và tiên lượng. Nghiên cứu khảo sát đặc điểm lâm sàng bệnh nhân vảy nến thể mảng, tỉ lệ và kiểu gen IL-17F RS763780, IL17RA rs4819554 và HLA-Cw6 ở người Việt Nam. 121 bệnh nhân vảy nến được lấy mẫu máu ngoại vi, sau đó tách chiết DNA và giải trình tự gen bằng phần mềm CLC Main Workbench v5.5. Độ nặng trung bình 20,31 ± 12,70 và PASI là 14,88 ± 7,59. Kết quả cho thấy có sự phân bố các genotype khác nhau trên mỗi vị trí khác nhau. Gen IL-17F đoạn rs763780 có tỉ lệ AA cao nhất trên nhóm bệnh nhân vảy nến chiếm 58,7%, GA chiếm 38,0%. Gen IL-17RA đoạn rs4819554 genotype GA có tỉ lệ là 53,7% và AA là 27,3%. Nhóm bệnh có tỉ lệ HLA-Cw6 âm tính và 35,04% và dương tính là 64,96%. Những bệnh nhân dương tính với HLA-Cw6, tỷ lệ dị hợp tử chiếm 77,63% và đồng hợp tử chiếm 22,37%. Chưa phát hiện mối liên quan giữa HLA-Cw6 với các SNP IL-17F RS763780 và IL17RA rs4819554. Tuy nhiên, có mối liên quan giữa IL-17F RS763780 lại có mối liên quan với độ nặng của bệnh.
ASSESSMENT OF THE OPERABILITY OF THE WATER HEATING SYSTEM, NOT RELEVANT TO THE PROJECT
Authors: NAVASELTSAU U. , NAVASELTSAVA D. 
Published: January 2023

When designing water heating systems, it is necessary to avoid unjustified use of excess equipment, exceeding diameters beyond the required values, etc. In reality, there are deviations from the project during installation, which lead to the need to revise the parameters of the system's operability. One of the cases is the replacement of pipelines of one diameter with another. Consideration of the prospects for the operation of such a heating system by example is the purpose of this work.
For example, the water heating system in a residential 11-storey building in Brest (Belarus) built in 2019 is considered. The house has designed an apartment-by-apartment two-pipe horizontal water heating system with the installation of heat meters for each apartment. When installing the heating system, the apartment-by-apartment branches of the heating system were mounted with polyethylene pipelines with a diameter of 18×2,5 mm and 14×2 mm instead of the design 25×3,5 mm and 16×2 mm.
To analyze the prospects for the functioning of the designed heating system, calculations of hydraulic resistances in the system at maximum coolant flow rates were performed, as well as their correlation with the parameters of the pumping equipment installed in the individual heating point.
Calculations have shown that the installed pump is sufficient for the operation of the heating system with the actual diameters of the pipelines. Thus, the actually applied pipe diameters do not adversely affect the performance of the heating system in question.
The Importance of IOL Selection in Patients With Young-age Cataracts: a Case Report
Authors: Petrovic Bobana , Biscevic Alma , Pjano Melisa , Salkica Ajla 
Published: January 2023

Background: A cataract is a type of degenerative change of the lens, which is characterized by the clouding of the lens followed by symptoms of optical deterioration. Over 70 years ago, Sir Harold Ridley implanted the first useable modern-day intraocular lens (IOL) implant. A lot has happened since then. The IOL is arguably the most life-changing and innovative implant in the history of medicine. Currently, there are several types of intraocular lenses on the market. The main classification could be monofocal lenses, multifocal, trifocal, extended depth of focus (EDOF) lenses, and toric lenses. Objective: The aim of this case report is to report the importance of IOL selection in patients with young-age cataracts. Case report: A 35-year-old patient presented first time at our Clinic. In the last six months, he noticed poor vision in his left eye, even with spectacles. The right eye was operated on in another institution in 2020, due to the presence of a young-age cataract. After a complete preoperative ophthalmological examination, we discovered the presence of a cataract in the left eye. UDVA of the left eye was 0.4, and CDVA was +0.50/+0.50/30°=0.5. UNVA and DCNVA was J2. We decided to implant TECNIS Synergy™ IOL (Johnson & Johnson Vision, Santa Ana, CA, USA) during the cataract surgery. That EDOF IOL bridges the gap between the performance of monofocal and multifocal IOLs and delivers continuous high-contrast vision for patients with cataracts from far through near, even in low-light conditions. There were no intraoperative or postoperative complications. On a 7-day, check-up UDVA of the left eye was 1.0, and UNVA was J1. The patient was satisfied with the vision in the left eye, so he wanted to correct the vision of the right eye which was implanted with SENSAR® IOL (Johnson & Johnson Vision, Santa Ana, CA, USA), with a residual diopter of +2.00/+1.00/120 for distance, and +4.50/+1.00/120 for near vision. This choice of IOL in the other institution was not an ideal solution for this patient due to his young age and occupation. The capsular bag was already in slight fibrosis, so the explantation of the existing IOL and implantation of the new one was not a reasonable option. We decided to go with the multifocal AddOn® toric lens (1stQ GmbH, Mannheim, Germany), the refractive-surgery platform for vision enhancement of pseudophakic eyes, that also correct residual astigmatism. On a 7-day check-up, this patient’s UDVA was 1.0 and UNVA was J1. The result was a happy patient, who could go back to his everyday life without spectacle independence. Conclusion: Good unaided distance visual acuity (VA) is now a realistic expectation following cataract surgery and intraocular lens (IOL) implantation. We should be aware of patient expectations and demands, especially when having a patient with young-age cataracts. Often more time should be spent on preoperative IOL planning than cataract surgery itself.
PENGARUH MOTIVASI DAN DISIPLIN KERJA TERHADAP PRESTASI KERJA PEGAWAI BADAN PENANGGULANGAN BENCANA DAERAH KABUPATEN PASAMAN BARAT
Authors: Endang Tirtana Putra  , Rita Oktavia  
Published: January 2023

Penelitian ini dilakukan di Badan Penanggulangan Bencana Daerah, Tujuan dari penelitian ini adalah: (1) Untuk mengetahui pengaruh Motivasi terhadap prestasi kerja pegawai, (2) Untuk mengetahui pengaruh Disiplin Kerja terhadap Prestasi kerja Pegawai, (3) Untuk mengetahui pengaruh Motivasi dan Disiplin Kerja terhadap Prestasi kerja Pegawai. Populasia adalah seluruh pegawai Kantor Badan Penanggulangan Bencana Daerah yang berjumlah 54 orang. Karena populasinya dibawah 100 orang maka pengambilan sampel menggunakan metode sensus artinya seluruh populasi dijadikan sampel, maka jumlah sampel 54 orang. Metode pengumpulan data yang digunakan adalah kuesioner. Metode analisis data yang digunakan adalah analisis deskriptif dan regresi linier berganda dengan menggunakan SPSS For Windows release 16.0. Hasil penelitian ini manunjukan adanya hubungan antara variable independen terhadap variable dependen. Dan dijelaskan bahwa: (1) Variabel Motivasi berpengaruh positif dan signifikan terhadap Prestasi kerja Pegawai pada Kantor Badan Penanggulangan Bencana Daerah, dengan koefisien regresi 0,277 dengan nilai signifikan 0,001 (<0,05), (2) Variabel Disiplin kerja berpengaruh positif dan signifikan terhadap Prestasi Kerja pegawai dengan nilai koefisien regresi 1,437 dengan nilai signifikan 0,000 (>0,05), (3) Variabel independen secara bersamaan berpengaruh positif dan signifikan terhadap prestasi kerja pegawai dengan nilai koefisien regresi 399.022 dengan nilai signifikan 0,000 (<0,05). Nilai R2 menunjukan 94,0% dan yang sisanya sebesar 6,0% dipengaruhi oleh variable lain yang tidak diikut sertakan dalam penelitian ini.
RESTRUKTURISASI KREDIT DENGAN JAMINAN HAK TANGGUNGAN PADA MASA PANDEMI COVID-19 DI BPR VII KOTO SUNGAI SARIK
Authors: Kiki Yulinda  , Dora Tiara  
Published: January 2023

Adanya wabah Corona virus Disease (Covid-19) di Indonesia membawa dampak bukan hanya di sektor kesehatan tetapi juga pada sektor ekonomi. Lumpuhnya kegiatan ekonomi akibat adanya physical distancing untuk menekan penyebaran virus, menyebabkan pertumbuhan ekonomi menjadi terhambat, sehingga mengakibatkan kegiatan bisnis perbankan menjadi macet atau bermasalah terutama dalam menjaga kolekbilitas kreditnya. Kondisi seperti ini akan berimbas pada menurunnya kemampuan membayar para debitur dari suatu Bank. Ketidak mampuan atau menurunya kemampuan dari debitur untuk membayar angsuran kreditnya adalah merupakan gejala awal dari timbulnya suatu kredit bermasalah dalam dunia perbankan. Untuk mengatasi hal ini maka pemerintah mengeluarkan kebijakan yang dinamakan Restrukturisasi Kredit. Restrukturisasi kredit adalah upaya perbaikan yang dilakukan bank dalam kegiatan perkreditan terhadap debitur yang mengalami kesulitan untuk memenuhi kewajibannya yang diatur dalam Peraturan Otoritas Jasa Keuangan No.11/POJK.03/2015 dan PBI Nomor 14/15/PBI/2012. Restrukturisasi adalah program sebagai suatu upaya perbaikan yang dilakukan dalam kegiatan perkreditan terhadap debitur yang mengalami kesulitan untuk memenuhi kewajibannya.
PROSPECTS FOR THE JOINT USE OF UNMANNED AERIAL VEHICLES
Authors: Kharchenko Oleksandr , Artushin Leonid , Kononov Oleksiy 
Published: January 2023

In the article, the development of methods of combat use of unmanned aerial vehicles (UAVs) from the point of view of cause and effect processes in the system "UAVs - means of enemy air defense - purposes of combat mission" is considered by the authors. The main factors of development and changes in the methods of combat use of UAVs are analyzed. The basic patterns and connections of the process of development of methods of joint use of UAVs, the area of conditions for the expedient use of groups of UAVs are highlighted. The scientific problem of the stochastic synthesis of the automated control system for the group application of UAVs, as one of the problems of modern control theory and technical cybernetics, is substantiated and formalized. The question of the possibility of reducing the task of stochastic synthesis of the automated control system for the group application of UAVs to the set of control optimization tasks in linear (linearized) systems according to quadratic criteria is considered.
МЕТОДИЧНИЙ ПІДХІД ЩОДО ПІДВИЩЕННЯ ТОЧНОСТІ ЗАСТОСУВАННЯ НЕКЕРОВАНИХ АВІАЦІЙНИХ РАКЕТ ШЛЯХОМ УРАХУВАННЯ ТЕМПЕРАТУРИ ТВЕРДОПАЛИВНИХ ДВИГУНІВ
Authors: Єрко Віктор , Шатров Андрій , Шишанов Михайло 
Published: January 2023

Метою статті є розробка авторами методичного підходу щодо підвищення точності застосування некерованих авіаційних ракет через урахування температури ракетного двигуна твердого палива. Отже розробка науково-обґрунтованих пропозицій підвищення точності рішення задачі прицілювання некерованих авіаційних ракет шляхом урахування впливу температури заряду їх ракетного двигуна твердого палива на повний імпульс тяги є актуальним науково-технічним завданням.
У статті викладено результати досліджень щодо можливості підвищення точності вирішення задачі прицілювання некерованими авіаційними ракетами шляхом урахування впливу температури заряду ракетного двигуна твердого палива на повний імпульс тяги та, як наслідок, на точність вирішення прицільної задачі. Для рішення цього завдання було використано методику виконання інженерно-штурманських розрахунків балістичного забезпечення стрільби некерованими авіаційними ракетами та ряд положень теорії вирішення задачі прицілювання по наземним цілям з літальних апаратів. При цьому некерована авіаційна ракета розглядається як снаряд зі складною балістичною схемою руху, що складається з активної та пасивної ділянок. Викладений алгоритм можна реалізувати шляхом внесення змін у відповідні робочі алгоритми прицільних (прицільно-навігаційних) систем літальних апаратів у вигляді прицільної поправки. У цьому випадку прицільна система не потребує додаткових юстировок, а решта кутових поправок прицілювання, які обумовлені швидкістю повітря (вітру), рухом літака, цілі (відповідно прийнятої гіпотези) тощо, розраховуються прицільною системою літака в автоматичному режимі і не будуть залежати від величини поправки.
АНАЛІЗ ПОКАЗНИКІВ ЕФЕКТИВНОСТІ ІНЖЕНЕРНО-АВІАЦІЙНОГО ЗАБЕЗПЕЧЕННЯ БОЙОВИХ ДІЙ БРИГАД ТАКТИЧНОЇ АВІАЦІЇ
Authors: Камишев Дмитро , Маракулін Олександр , Невзгляденко Юрій 
Published: January 2023

У статті розглядається вибір та обґрунтування сукупності показників для оцінювання ефективності інженерно-авіаційного забезпечення, здійснюється визначення комплексного показника ефективності, що дає можливість всебічно оцінити ефективність інженерно-авіаційного забезпечення бригад тактичної авіації, які озброєні різними типами авіаційної техніки, в різних умовах бойової обстановки. Всі показники, включно із комплексним показником ефективності інженерно-авіаційного забезпечення бойових дій (бойової підготовки) бригад тактичної авіації, визначаються математичними методами (експертних оцінок та кваліметрії), мають безромірну величину та зручні у якісному порівняльному аналізі. Приведений у статті перелік показників не є вичерпним, він може бути змінений, але зміст методу порівняння ефективності інженерно-авіаційного забезпечення за допомогою комплексного показника ефективності від цього не зміниться.
Variasi Bahan Pakaian Dan Kejadian Keputihan
Authors: Rukmana Sitti 
Published: January 2023

Keputihan merupakan gejala yang sangat sering dialami oleh sebagian besar wanita. Bahan pakaian dapat menyebabkan terjadinya keputihan. Bahan dari celana dalam juga cukup krusial dalam mempengaruhi resiko keputihan Tujuan Mengetahui Hubungan Variasi Penggunaan Bahan Pakaian dan Kejadian Keputihan di STIE Mujahidin Tolitoli.
Desain yang digunakan dalam penelitian adalah Cross Sectional. Populasi adalah Semua remaja putri. Besar sampel adalah 30 responden dengan menggunakan teknik Random sampling. Variabel Independen penelitian adalah Variasi jenis pakaian. Variabel dependen adalah Kejadian keputihan. Data dikumpulkan dengan menggunakan kuesioner, kemudian data dianalisis menggunakan uji Chi square dengan tingkat signifikansi α ≤ 0,05.
Hasil penelitian didapatkan bahwa hampir setengah responden memiliki jenis pakaian katun sebanyak 12 responden (40%), kejadian keputihan sebanyak 19 responden (63,3%). Hasil penelitian didapatkan a< 0,05 didapatkan p=0,000 dimana H1 diterima dan H0 ditolak yang berarti bahwa terdapat ada hubungan Variasi Penggunaan Bahan Pakaian dan Kejadian Keputihan di STIE Mujahidin Tolitoli
Terdapat Hubungan Variasi Penggunaan Bahan Pakaian dan Kejadian Keputihan di STIE Mujahidin Tolitoli. Jenis bahan yang tepat akan meminimalkan kejadian keputihan dan Kesehatan.
Classic Mozart And Murrotal Alquran Therapy Music For Increasing Body Weight In LBW Infants
Authors: Jaya Nur , Kadhim Salih 
Published: January 2023

Background: Low Birth Weight (LBW) continues to be a significant global health problem. If there is LBW, then there must be an effort to increase the baby's weight. One of them is by giving Mozart classical music therapy. Besides that, you can also use the Qur'an's total therapy. The voice of Al-Qur'an (Murottal) has benefits that can affect health. Objective To find out the differences between Mozart's classical music therapy and Murrotal Qur'an therapy to increase body weight in LBW infants aged 0-28 days.
Methods: The design used in the study was quasi-experimental. The population is all infants aged 0-28 days. The sample size is 30 respondents using the Purposive sampling technique. Independent variables of the study are classical Mozart music therapy and Murrotal Qur'an therapy. The dependent variable is the increase in body weight in LBW infants aged 0-28 days. Data was collected using a questionnaire, and then the data were analyzed using the Wilcoxon test with a significance level of α ≤ 0.05.
Results: The results showed that respondents had a weighted average of before Mozart's Music Therapy of 2242.0 grams, and after Mozart's Music Therapy of 2431.3 grams, weight Before Koran Murotal Therapy was 2049.3 grams, and after Koran Murotal Therapy of 2496, 0 grams. The results showed that p = 0.023 where H1 was accepted and H0 was rejected, which means that there were differences in Mozart's classical music therapy and Murrotal Alquran therapy for weight gain in LBW infants aged 0-28 days.
Conclusion: There are differences in Mozart's classical music therapy and Murrotal Alquran therapy for increasing body weight in LBW infants aged 0-28 days.
Relations Between Stress Level With Recurrence Of Hypertension Disease To Patients Aged 40-60 Years Old In Community Health Center Level II Municipality Lospalos, Timor Leste
Authors: Pires Alexandra Maria , Oqui Maximiano , Soares Virgilio , Xavier Benito Oliveira F. , Mahyuvi Tata 
Published: January 2023

Background: For people who get a kind of disease, the medic diagnosis of Hypertension is when their blood pressure is >140/90 mmHg. Those factors that influence added blood pressure are lifestyles, such as smoking, salt intake, obesity, physical activity and stress, genetic factor, inadequate vasoconstriction modulator, vasodilatation, renin system, angiotensin, and aldosterone. The objective of this research is to analyze the “Relationship between stress level with recurrence of Hypertension disease to a patient aged 40-60 years old in Centro Saúde Comunitária Nível II Lospalos, in 2022 years”.
Methods: This research uses the quantitative method and cross-sectional approximation conducted in Centro Saúde Comunitária Nível II Lospalos in 2022. The population to be sampled is Hypertension patients aged 40-60 years old, and the sampling result is defined as 91. For technique data collection, the researcher uses a questionnaire. Analyze data technique uses the chi quadrat statistic test.
Results: The result of analyzing Chi-Square defined by this research is a significate value of 0.016<0.05 significate unacceptable Ho, and also results by Shi-Square Linear-by-Linear Association of statistic 0.399 meaning less relationship between stress level with recurrence of Hypertension disease to the patient with aged 40-60 years old. The results of Chi-Square have a relationship between stress level and recurrence of Hypertension disease to patients aged 40-60 years old.
Conclusion: Stress level is the main risk of recurrence of hypertension. When stress to the patient's recurrence of Hypertension will occur another complication, hypertension is also a kind of disease that is very dangerous to distribute and cause mortality. Hypertension sometimes, other people call silence killer.
Een ruimere invulling van het begrip ‘bedrijfsmatig gebruik’ van een dier
Authors: Engelen S.S.Y. 
Published: January 2023

Een ruimere invulling van het begrip ‘bedrijfsmatig gebruik’ van een dier. Rb. Noord-Nederland 6 april 2022, ECLI:NL:RBNNE:2022:1512; Hof Arnhem-Leeuwarden 26 april 2022, ECLI:NL:GHARL:2022:3241
In deze noot bespreekt de auteur naar aanleiding van twee recente uitspraken de invulling van het begrip bedrijfsmatig gebruik uit artikel 6:181 BW voor de verlegging van aansprakelijkheid uit artikel 6:179 BW voor de door een dier aangerichte schade van de bezitter naar de bedrijfsmatig gebruiker. Het valt de auteur op dat beide instanties bij de waardering van de feiten voor de uitleg van het begrip bedrijfsmatig gebruik een andere toepassing lijken te geven aan de in het Loretta-arrest geformuleerde gezichtspunten. Met name de vraag of aan de elementen ‘zeggenschap’ en ‘profijt’ betekenis toekomt, en zo ja, welk gewicht deze in het kader van de beoordeling dienen te krijgen, wordt verschillend beantwoord. Het hof lijkt met zijn arrest bewust een nieuwe stap te zetten in de richting van een ruime(re) invulling van het begrip bedrijfsmatig gebruik met een belangrijke rol voor de vraag welke partij in het concrete geval zeggenschap heeft over het dier.
Desenvolvimento de ferramentas para modelar a dispersão de contaminantes atmosféricos com dados públicos brasileiros usando o modelo AERMOD
Authors: Grillo Guzmán Nely , Sanchez Dominguez Joel , Teixeira de Assis Joaquim 
Published: January 2023

A relevância de simular a dispersão dos contaminantes atmosféricos é amplamente aceita pela comunidade científica e a sociedade; conhecendo os graves danos que a poluição atmosférica pode causar à saúde humana. O AERMOD, é um modelo de dispersão de contaminantes que incorpora a dispersão do ar com base na estrutura de turbulência da camada limite planetária e conceitos de dimensionamento. Para a execução do AERMOD é preciso executar alguns pré-processadores que adequam os dados de entrada do modelo. Com os dados públicos brasileiros não foi possível executar os pré-processadores AERSURFACE e AERMAP, verificando-se a necessidade de criar ferramentas que pudessem substituí-los. Foram criados o DATASURFACE e DATAMAP, os quais conseguem gerar os dados necessários para a execução do AERMOD usando os dados disponíveis publicamente no Brasil. Os resultados mostram que o DATASURFACE pode ser usado para gerar os dados de comprimento de rugosidade da superfície da terra, albedo e razão de Bowen, e a saída do DATAMAP pode ser usada para colocar no arquivo de entrada do AERMOD os dados de altitude e de escala de altura de colina necessários para sua execução. Ambos os programas desenvolvidos produzem arquivos de saída compatíveis com os arquivos de entrada necessários para executar o AERMOD. Ao usar os dados gerados pelas ferramentas desenvolvidos na execução do AERMOD, no caso de estudo apresentado, os resultados mostram que sua inclusão obteve padrões de dispersão de contaminantes com maior acurácia, porque representam melhor o efeito das variações no relevo da área em análise.
AN ANALYSIS OF TAZKARA HAZAR DASTAAN KNOWN AS KHUMKNANAE JAVEED BY LALA SRI RAM
Authors: Dr Zafar Hussain Haral  , Zaib-un-Nisa  
Published: January 2023

Tazkara is a type of biography in Urdu literature. In Tazkara the researcher compiles the data and events of the lives of poets and other literary personalities. Tazkara Hazar Dastaan known as Khumkhanae Javeed was gathered by Lala Sri Ram. This biography consists of Six volumes. There are 689 pages in Volume 1 and a list of 634 poets according to the Urdu alphabet ا تا بby poetic names included in it. Volume 2 consists of 751 pages with a list of 485 poets by poetic names according to پ تا ح. Volume 3 consists of 737 pages with a list of 534 poets by poetic names according to خ تا ز. Volume 4 consists of 628 pages with a list of 421 poets by poetic names according to س تا ش. Volume 5 consists of 616 pages with a list of 647 poets by poetic names according to ش تا ع. Volume 6 consists of 556 pages with a list of 458 poets by poetic names according to ع تا ے. There are 3977 pages and 3179 poets in all volumes. It is a remarkable work. In this article, this biography is critically analyzed.
Great leaps in multiple sclerosis treatment but the holy grail is still ahead
Authors: Greenland Rohan 
Published: January 2023

Great leaps in multiple sclerosis treatment but the holy grail is still ahead
MS is an autoimmune disease of the central nervous system (CNS), affecting the brain, optic nerve and spinal cord. In MS, the immune system mistakenly attacks the myelin sheath around the nerves, disrupting the conduction of nerve signals to other parts of the body. There are many symptoms that can be variable and unpredictable depending on which part of the CNS is damaged. They can be a one-off occurrence, come and go or change in severity over time, contributing to the uncertainty that MS brings. Here CEO of MS Australia Rohan Greenland highlights the breakthroughs in treating attacks on the brain and spinal cord in multiple sclerosis (MS). But his sights are set firmly on the great unmet needs: to repair damaged nerves, reverse disability, and ultimately, prevent MS.