bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarker-Directed Radiotherapy in Breast Cancer
Authors: Meattini Icro , Coles Charlotte E. , Tramm Trine , Borghesi Simona , Krug David , Montero Angel , Nardone Valerio , Salvestrini Viola , Valzano Marianna , Valentini Vincenzo , Aristei Cynthia , Poortmans Philip ,   Assisi Think Tank Meeting Investigators, Arenas Meritxell , Boersma Liesbeth J. , Bolukbasi Yasemin , Ciabattoni Antonella , Franco Pierfrancesco , Genovesi Domenico , Kaidar Person Orit , Kouloulias Vassilis , Krengli Marco , Leonardi Maria Cristina , Lozza Laura , Marazzi Fabio , Masiello Valeria , Morganti Alessio G. , Offersen Birgitte , Palumbo Isabella , Pedretti Sara , Perrucci Elisabetta , Ratosa Ivica , Rivera Sofia , Garcia Trigo Maria de Lurdes 
Published: January 2025

ImportanceIntegration of molecular biomarker information into systemic therapy has become standard practice in breast cancer care. However, its implementation in guiding radiotherapy (RT) is slower. Although postoperative RT is recommended for most patients after breast-conserving surgery and, depending on risk factors, following mastectomy, emerging evidence has indicated that patients with low scores on gene expression signatures or selected clinical-pathological features may have very low local recurrence rates. This narrative review explored the potential of biomarker-directed personalized RT approaches, which may optimize treatment strategies and be associated with improved patient outcomes and experiences.ObservationsDistinctions between prognostic and predictive biomarkers were highlighted, emphasizing the importance of analytical and clinical validity in biomarker-based studies. Findings from studies investigating the prognostic and predictive value of various genomic signatures and immunohistochemical markers for guiding breast RT were presented. These included the Adjuvant Radiotherapy Intensification Classifier and the Profile for the Omission of Local Adjuvant Radiation, which have shown potential in predicting RT benefits. The genomic-adjusted radiation dose and role of tumor-infiltrating lymphocytes were also discussed. Ongoing clinical trials exploring the use of biomarkers in ductal carcinoma in situ and invasive breast cancer to refine RT decision-making were illustrated.Conclusions and RelevanceThe results of this narrative review suggest that evidence-based shared decision-making is crucial to optimize treatment according to the individual’s predicted benefits and risks along with their personal preferences. Incorporation of biomarker-directed approaches in RT for breast cancer may hold promise for personalized treatment, potentially facilitating omission of RT for patients at low risk of recurrence, while identifying those who may benefit from intensified therapy. This personalized RT approach may be associated with improved clinical outcomes and quality of life and facilitate decision-making for people with breast cancer. However, there remains a need for robust clinical and analytical validation of biomarkers to ensure reliability and clinical utility for RT optimization.
Speech Perception in Noise After Cochlear Implantation for Single-Sided Deafness
Authors: van Heteren Jan A. A. , Wendrich Anne W. , Peters Jeroen P. M. , Grolman Wilko , Stokroos Robert J. , Smit Adriana L. 
Published: January 2025

ImportanceThere is a lack of high level of evidence studies comparing the effect of different treatment options for single-sided deafness (SSD).ObjectiveTo determine the effect of a cochlear implant (CI), bone conduction device (BCD), contralateral routing of signals hearing aid (CROS), and no treatment on speech perception in noise outcomes in patients with SSD.Design, Setting, and ParticipantsIn this single-center randomized clinical trial, adult patients with SSD were randomized into 3 groups: CI; a trial period with first a BCD on a headband and then a CROS; or a trial period with first a CROS and then a BCD on a headband. After the trial periods, patients opted for a BCD, CROS, or no treatment. Measurements were completed at baseline and at 3, 6, 12, and 24 months of follow-up. Data were collected from July 2014 to October 2021, and data were analyzed from December 2022 to May 2023.InterventionsCI, BCD then CROS, or CROS then BCD.Main Outcomes and MeasuresThe primary outcome was the speech reception threshold in noise (SRTn), measured with speech and noise from the front (S0N0), speech directed to the poor ear and noise to the better ear (SpeNbe), and vice versa (SbeNpe). The secondary outcome was disease-specific quality of life (QOL).ResultsOf 120 included patients, 60 (50.0%) were female, and the mean (SD) age at inclusion was 53.0 (12.1) years. At the start of follow-up, 28 patients received a CI, 25 a BCD, 34 a CROS, and 26 chose no treatment. At 24 months, the CI group had significantly better speech perception in noise scores than the BCD group (difference in SRTn: SbeNpe, −4.7 dB; 95% confidence interval, −6.6 to −3.0; SpeNbe, −2.2 dB; 95% confidence interval, −4.6 to −1.1), the CROS group (difference in SRTn: S0N0, −1.3 dB; 95% confidence interval, −1.7 to −0.2; SbeNpe, −5.3 dB; 95% confidence interval, −6.0 to −3.1), and the no treatment group (difference in SRTn: SpeNbe, −6.3 dB; 95% confidence interval, −7.5 to −4.9). Compared with the no treatment group, the BCD and CROS groups showed significantly better (difference in SRTn for SpeNbe, −4.1 dB [95% confidence interval, −5.2 to −1.5] and −4.1 dB [95% confidence interval, −6.1 to −3.3], respectively) or worse (difference for SbeNpe, 4.0 dB [95% confidence interval, 2.6 to 6.2] and 4.6 dB [95% confidence interval, 2.8 to 5.7], respectively) speech perception in noise. Self-reported speech perception abilities were significantly better for the CI group compared with the BCD, CROS, and no treatment groups.Conclusions and RelevanceIn this randomized clinical trial, the CI group outperformed the BCD, CROS, and no treatment groups in terms of speech perception in noise and disease-specific QOL in patients with SSD after 24 months of follow-up. These results indicate that patients with SSD can partially regain the advantages of binaural hearing after treatment.Trial Registrationtrialregister.nl Identifier: NL4457
Cationic Vacancy Modulation of Mn3O4 as a Superior Cathode for Durable Aqueous Zinc‐Ion Batteries
Authors: Deng Shenzhen , Xu Bingang , Liu Xinlong , Yang Yujue , Xiao Yana , Wang Shuai , Zhao Jingxin , Chen Tiandi 
Published: January 2025

AbstractAqueous zinc‐ion batteries (AZIBs) have attracted more and more attention owing to their high safety, low cost, and environmental friendliness. Mn‐based materials are considered as one of the most promising cathode materials for AZIBs because of their high output voltage, eco‐friendliness, and abundance. However, the low electrochemical activity and the manganese dissolution of Mn3O4 lead to the low specific capacity and inferior cycling stability, hindering its practical applications. Herein, a facile and low‐cost strategy is designed that combines cationic vacancy modulation with Mn ion‐confinement effect in a synergistic action to boost zinc ion energy storage capability of inert Mn3O4 (designated as VMn‐Mn3O4@C). The cationic vacancy endows Mn3O4 with more active sites, resulting in an increased specific capacity. Meanwhile, the manganese dissolution is inhibited via the Mn ion‐confinement effect of the carbon framework, thereby improving the cycling stability of the cathode. Consequently, the developed Zn/VMn‐Mn3O4@C batteries deliver a high specific capacity of 280.9 mAh g−1 and 98.4% capacity retention after 100 cycles at 0.1 A g−1. More importantly, VMn‐Mn3O4@C cathodes maintain superior cycling stability of 5000 cycles with nearly 100% capacity retention at 1 A g−1.
Coplanar Pattern and Temperature Transient Control in Intelligent Wearable Multi‐Color Alternating Current Electroluminescence Devices
Authors: Wang Xun , Lin Yuting , Zhang Ying , Xu Shilin , Liu Mingyu , Shen Yaoxi , Gong Yingzhen , Xiong Yarui , Hu Yi 
Published: January 2025

AbstractFlexible alternating current electroluminescence (ACEL) devices integrated into textiles are gaining significant attention for their potential in lighting displays and health monitoring applications. Traditional challenges include high‐voltage “breakdown” and limited color output due to the inherent properties of ZnS:Cu. This study introduces a novel multi‐color ACEL device featuring a fluorescent dye color conversion layer alongside a robust protective layer designed to enhance device stability. The optimal ratio of dielectric layer concentration and protective layer thickness is systematically investigated to mitigate the risk of “breakdown”. Utilizing the principles of photoluminescence and electroluminescence, luminous electronic textile devices is successfully developed that exhibit both purple and green luminescence. Additionally, integration with a temperature sensor enables the device to serve as a health‐monitoring tool by signaling changes in body temperature. This research delineates the protective capabilities of the protective layer and the efficacy of the color conversion mechanism in maintaining consistent brightness under various conditions. The findings suggest a viable pathway for broadening applications and potentially accelerating the commercialization of wearable electroluminescent technologies.
A Facile Approach To Develop Ion Pair Micelles Satellited Freshly Derived Neutrophils For Targeted Tumor Therapy
Authors: Sharma Garima , Wangpimool Kwanjira , George Joy Jomon , Sharma Ashish Ranjan , Son Hyeon Ki , Kim Songrae , Jeong Hoibin , Kim Jin‐Chul 
Published: January 2025

AbstractImmune cells show enormous potential for targeted nanoparticle delivery due to their intrinsic tumor‐homing skills. However, the immune cells can internalize the nanoparticles, leading to cellular functional impairments, degradation of the nanoparticles, and delayed release of drugs from the immune cells. To address these issues, this study introduces an approach for the synthesis of freshly derived neutrophils (NUs)‐based nanocarriers system where the NUs are surfaced by dialdehyde alginate‐coated self‐assembled micelles loaded with mitoxantrone (MIT) and indocyanine green (ICG) (i.e., dA(MI@IPM)s) for stimuli‐responsive tumor‐targeted therapy. Here, the dA(MI@IPM)s are not internalized by the NUs, but they are anchored on the membrane of the NUs via distearoylphosphatidylethanolamine‐polyethylene glycol‐polyethylenimine anchors. Owing to the natural recruitment ability of NUs to the tumor microenvironment, NUs‐anchored dA(MI@IPM)s accumulation is higher at the tumor site than free dA(MI@IPM)s, where the dA(MI@IPM)s can readily detach from the NUs to get internalized in the tumor cells. The stimuli‐responsive dA(MI@IPM)s disassembles inside the cancer cells upon near‐infrared irradiation due to the photosensitizing effect of the loaded ICG, releasing MIT and significantly inhibiting tumor growth. This approach is simple and fast to prepare, opening up exciting possibilities for personalized cancer treatment using patient's autologous NUs.
Transition of Perovskite Solar Technologies to Being Flexible
Authors: Castriotta Luigi Angelo , Uddin Md Aslam , Jiao Haoyang , Huang Jinsong 
Published: January 2025

AbstractPerovskite technologies has taken giant steps on its advances in only a decade time, from fundamental science to device engineering. The possibility to exploit this technology on a thin flexible substrate gives an unbeatable power to weight ratio compares to similar photovoltaic systems, opening new possibilities and new integration concepts, going from building integrated and applied photovoltaics (BIPV, BAPV) to internet of things (IoT). In this perspective, the recent progress of perovskite solar technologies on flexible substrates are summarized, focusing on the challenges that researchers face upon using flexible substrates. A dig into material science is necessary to understand what kind of mechanisms are limiting its efficiency compare to rigid substrates, and which physical mechanism limits the upscaling on flexible substrate. Furthermore, an overview of stability test on flexible modules will be described, suggesting common standard procedure and guidelines to follow, showing additional issues that flexible modules face upon bending, and how to prevent device degradation providing an ad‐hoc encapsulation. Finally, the recent advances of flexible devices in the perovskite market will be shown, giving an outline of how this technology is exploited on flexible substrates, and what are still missing that need stakeholders’ attention.
Recent Progress and Advances of Perovskite Crystallization in Carbon‐Based Printable Mesoscopic Solar Cells
Authors: Xiang Junwei , Han Chuanzhou , Cheng Yanjie , Gao Qiaojiao , Hu Wenjing , Zhou Yang , Mei Anyi , Zhou Yinhua , Han Hongwei 
Published: January 2025

AbstractCarbon‐based printable mesoscopic solar cells (p‐MPSCs) offer significant advantages for industrialization due to their simple fabrication process, low cost, and scalability. Recently, the certified power conversion efficiency of p‐MPSCs has exceeded 22%, drawing considerable attention from the community. However, the key challenge in improving device performance is achieving uniform and high‐quality perovskite crystallization within the mesoporous structure. This review highlights recent advancements in perovskite crystallization for p‐MPSCs, with an emphasis on controlling crystallization kinetics and regulating perovskite morphology within confined mesopores. It first introduces the p‐MPSCs, offering a solid foundation for understanding their behavior. Additionally, the review summarizes the mechanisms of crystal nucleation and growth, explaining how these processes influence the quality and performance of perovskites. Furthermore, commonly applied strategies for enhancing crystallization quality, such as additive engineering, solvent engineering, evaporation controlling, and post‐treatment techniques, are also explored. Finally, the review proposes several potential suggestions aimed at further refining perovskite crystallization, inspiring continued innovation to address current limitations and advance the development of p‐MPSCs.
Advances in Oxygen Evolution Reaction Electrocatalysts via Direct Oxygen–Oxygen Radical Coupling Pathway
Authors: Rong Chengli , Huang Xinyi , Arandiyan Hamidreza , Shao Zongping , Wang Yuan , Chen Yuan 
Published: January 2025

AbstractOxygen evolution reaction (OER) is a cornerstone of various electrochemical energy conversion and storage systems, including water splitting, CO2/N2 reduction, reversible fuel cells, and rechargeable metal‐air batteries. OER typically proceeds through three primary mechanisms: adsorbate evolution mechanism (AEM), lattice oxygen oxidation mechanism (LOM), and oxide path mechanism (OPM). Unlike AEM and LOM, the OPM proceeds via direct oxygen–oxygen radical coupling that can bypass linear scaling relationships of reaction intermediates in AEM and avoid catalyst structural collapse in LOM, thereby enabling enhanced catalytic activity and stability. Despite its unique advantage, electrocatalysts that can drive OER via OPM remain nascent and are increasingly recognized as critical. This review discusses recent advances in OPM‐based OER electrocatalysts. It starts by analyzing three reaction mechanisms that guide the design of electrocatalysts. Then, several types of novel materials, including atomic ensembles, metal oxides, perovskite oxides, and molecular complexes, are highlighted. Afterward, operando characterization techniques used to monitor the dynamic evolution of active sites and reaction intermediates are examined. The review concludes by discussing several research directions to advance OPM‐based OER electrocatalysts toward practical applications.
Shear‐Mediated Stabilization of Spin Spiral Order in Multiferroic NiI2
Authors: Tseng Yi , Occhialini Connor A. , Song Qian , Barone Paolo , Patel Sahaj , Shankar Meghna , Acevedo‐Esteves Raul , Li Jiarui , Nelson Christie , Picozzi Silvia , Sutarto Ronny , Comin Riccardo 
Published: January 2025

AbstractType‐II multiferroicity from non‐collinear spin order is recently explored in the van der Waals material NiI2. Despite the importance for improper ferroelectricity, the microscopic mechanism of the helimagnetic order remains poorly understood. Here, the magneto‐structural phases of NiI2 are investigated using resonant magnetic X‐ray scattering (RXS) and X‐ray diffraction. Two competing magnetic phases are identified. Below 60 K, an incommensurate magnetic reflection (q ≈ [0.143,0,1.49] reciprocal lattice units) is observed which exhibits finite circular dichroism in RXS, signaling the inversion symmetry‐breaking helimagnetic ground state. At elevated temperature, in the non‐polar phase (60 K < T < 75 K), a distinct q ≈ [0.087,0.087,1.5] magnetic order is observed, attributed to a collinear incommensurate (CI) state. The first‐order CI‐helix transition is concomitant with a structural transition characterized by a significant interlayer shear, which drives the helimagnetic ground state as evidenced by a mean‐field Heisenberg model including interlayer exchange and its coupling to the structural distortion. These findings identify interlayer magneto‐structural coupling as the key driver behind multiferroicity in NiI2.
A Robust, Biodegradable, and Fire‐Retardant Cellulose Nanofibers‐Based Structural Material Fabricated from Natural Sargassum
Authors: Li De‐Han , Han Zi‐Meng , Shao Meng , Jiao Zhi‐Jin , Gao Chen , Sun Wen‐Bin , Liu Zhao‐Xiang , Yang Kun‐Peng , Guan Qing‐Fang , Yu Shu‐Hong 
Published: January 2025

AbstractWith increasing concern about the environmental pollution of petrochemical plastics, people are constantly exploring environmentally friendly and sustainable alternative materials. Compared with petrochemical materials, cellulose has overwhelming superiority in terms of mechanical properties, thermal properties, cost, and biodegradability. However, the flammability of cellulose hinders its practical application to a certain extent, so improving the fire‐retardant properties of cellulose nanofiber‐based materials has become a research focus. Here, cellulose nanofiber and alginate are extracted from abundant natural sargassum as high‐strength nanoscale building blocks, and then a sargassum cellulose fire‐retardant structural material is prepared through a bottom‐up hydrogel layer‐by‐layer method. The structural materials obtained incorporate excellent mechanical properties (≈297 MPa), thermal stability (≈200 °C), low thermal expansion coefficient (≈7.17 × 10−6 K−1), and fire‐retardant properties. This work largely improves the utilization of seaweed residue and natural polymers, providing a bio‐based fire‐retardant strategy, and has a wide range of development prospects in the field of fiber‐based high‐performance structural materials in the future.
Dynamic Reconstruction of Fluid Interface Manipulated by Fluid Balancing Agent for Scalable Efficient Perovskite Solar Cells
Authors: Sun Kai , Wang Zhen , Li Naizhen , Liu Licheng , Xiong Wei , Xu Zengjie , Geng Zhi , Guo Xiaoyang , Jiang Yue , Feng Shien‐Ping , Gao Xingsen , Chen Yiwang , Liu Junming , Gao Jinwei 
Published: January 2025

AbstractLaboratory‐scale spin‐coating techniques are widely employed for fabricating small‐size, high‐efficiency perovskite solar cells. However, achieving large‐area, high‐uniformity perovskite films and thus high‐efficiency solar cell devices remain challenging due to the complex fluid dynamics and drying behaviors of perovskite precursor solutions during large‐area fabrication processes. In this work, a high‐quality, pinhole‐free, large‐area FAPbI3 perovskite film is successfully obtained via scalable blade‐coating technology, assisted by a novel bidirectional Marangoni convection strategy. By incorporating methanol (MeOH) as a fluid balance agent, the direction of Marangoni convection is effectively regulated, mitigating the disordered motion of colloidal precursor particles during the printing process. As a result, champion power conversion efficiencies (PCEs) of 24.45% and 20.32% are achieved for small‐area FAPbI3 devices (0.07 cm2) and large‐area modules (21 cm2), respectively. Notably, under steady illumination, the device reached a stabilized PCE of 24.28%. Furthermore, the unencapsulated device exhibited remarkable operational stability, retaining 92.03% of its initial PCE after 1800 h under ambient conditions (35 ± 5% relative humidity, 30 °C). To demonstrate the universality of this strategy, a blue perovskite light‐emitting diode is fabricated, showing an external quantum efficiency (EQE) of 14.78% and an electroluminescence wavelength (EL) of 494 nm. This work provides a significant technique for advancing solution‐processed, industrial‐scale production of high‐quality and stable perovskite films and solar cells.
Formal [3+1+1+1] Annulation of 2‐Isocyanophenyl Propargylic Esters and 4‐Hydroxy‐2H‐Chromen‐2‐Ones: An Access to Quinoline‐Fused Polycyclic Skeletons
Authors: Xing Yu , Li Xiangheng , Ni Zihan , Guo Jiajian , Zhou Zijun , Cui Lei , Li Chunju , Li Jian 
Published: January 2025

AbstractA cascade reaction involving 2‐isocyanophenyl propargylic ester and 4‐hydroxy‐2H‐chromen‐2‐one has been documented. This reaction leads to the formation of a highly strained cyclopropen‐imine species, thereby offering an efficient route to synthesize quinoline‐fused polycyclic skeletons.
1,3‐Iodoesterification of 2‐Substituted Indoles via Csp2−H/Csp3−H Retained Dual Functionalization Using Hypervalent Iodine(III)
Authors: Wasaki Hiroko , Moriyama Katsuhiko 
Published: January 2025

AbstractA 1,3‐iodoesterification of 2‐substituted indoles with trihaloacetic acid, iodination reagent, and hypervalent iodine(III) compound was developed as an acid‐promoted Csp2−H/Csp3−H dual functionalization reaction to furnish 3‐iodo‐2‐trihaloacetoxymethyl indoles. The one‐pot 1,3‐iodoesterification/hydrolysis of the trihaloester group provided 3‐iodo‐2‐pivaloylmethyl indoles via the rearrangement of the pivaloyl group. The reaction proceeded through a trihaloacetic acid‐assisted electrophilic activation of the iodination reagent after the formation of an indolyl(mesityl)iodonium trihaloacetate.
Surface‐Functionalized Diatoms as Green Nano‐Adsorbents for the Removal of Methylene Blue and Methyl Orange as Model Dyes from Aqueous Solution
Authors: Ojike Chidinma Akobueze , Hagen Volker , Beszteri Bank , Galstyan Anzhela 
Published: January 2025

AbstractWater pollution from the chemical industry has become a significant and widespread global environmental problem. This necessitates the development of cost‐effective adsorbents with rapid removal efficiency. In this paper, the use of low‐cost and globally available diatomaceous earth (DE) is decribed as a sorbent for the removal of model dyes, methylene blue (MB) and methyl orange (MO). The skeleton is chemically modified to achieve highly selective sorption and the results are compared with silica (Si) which has the same functionalities. The adsorption performance of the sorbents obtained is investigated by varying different parameters such as pH value, adsorbent dosage, initial concentration of dye, and contact time. Diatomaceous earth functionalized with carboxyl groups showed a better removal efficiency of MB (up to 100%) than functionalized silica. The removal of MO with functionalized imidazolium species is found to be comparable (up to 70%). The adsorption kinetics are investigated using first and second‐order pseudo‐models, with the latter showing superior agreement with the experimental data. The results demonstrate the potential of biosorbents to enable energy‐efficient water remediation.