bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penalty Zones in International Sustainability Standards: Where Improved Sustainability Doesn't Pay
Authors: Darnall Nicole , Iatridis Konstantinos , Kesidou Effie , Snelson‐Powell Annie 
Published: July 2023

AbstractAdopting an international sustainability standard (ISS) helps firms improve their sustainability performance. It also acts as a credible market ‘signal’ that legitimizes firms' latent sustainability practices while improving their market value. But how do these signals function when firms adopt multiple ISSs? We show that the relationships between firms' ISSs adoption and their market value and their sustainability performance appear positive. However, beyond a tipping point of 2 ISSs, firms' market gains decline, even though their sustainability performance continues to improve until a tipping point of 3 ISSs. Differing tipping points create a gap that we refer to as the ‘penalty zone’ – the place where market value declines, even though firms' actual sustainability performance continues to improve. The penalty zone arises because of imprecisions in market signals and serves as a significant barrier to firms wishing to further their sustainability agenda through additional ISS adoption.
Associated factors of nurse‐sensitive patient outcomes: A multicentred cross‐sectional study in psychiatric inpatient hospitals
Authors: Desmet Karel , Bracke Piet , Deproost Eddy , Goossens Peter J. J. , Vandewalle Joeri , Vercruysse Lieke , Beeckman Dimitri , Van Hecke Ann , Kinnaer Lise‐Marie , Verhaeghe Sofie 
Published: July 2023

Accessible SummaryWhat is already known?

The nurse–patient relationship in mental health care is an important focus of mental health nursing theories and research.

There is limited evidence about which factors influence nurse‐sensitive patient outcomes of the nurse–patient relationship. This hinders the development, planning, delivering, and quality assurance of the nurse–patient relationship in nursing practice and nursing education.

What this paper adds to existing knowledge?

To our best knowledge, this is the first study to examine associations between nurse‐sensitive patient outcomes of the nurse–patient relationship and a range of patient characteristics and relationship‐contextual factors.

In this study, we found that gender, age, hospital characteristics, nurse availability when needed, nurse contact, and nurse stimulation were associated with the scores on the nurse‐sensitive patient outcome scale.

What are the implications for practice?

Having insight into the factors associated with nurse‐sensitive patient outcomes of the nurse–patient relationship can help nurses, nursing students, nursing management and also patients to enhance the nurse–patient relationship, trying to influence outcomes of nursing care.

AbstractIntroductionThe lack of evidence on patient characteristics and relational‐contextual factors influencing nurse‐sensitive patient outcomes of a nurse–patient relationship is a possible threat to the quality and education of the nurse–patient relationship.AimTo measure nurse‐sensitive patient outcomes of the nurse–patient relationship and to explore the associations between nurse‐sensitive patient outcomes and a range of patient characteristics and relational‐contextual factors.MethodIn a multicenter cross‐sectional study, 340 inpatients from 30 units in five psychiatric hospitals completed the Mental Health Nurse‐Sensitive Patient Outcome Scale. Descriptive, univariate and Linear Mixed Model analyses were conducted.ResultsOverall, patient‐reported outcomes were moderate to good. Female participants, nurse availability when needed, more nurse contact and nurse stimulation were associated with higher outcomes. Age differences were observed for some of the outcomes. Outcomes also varied across hospitals but were not related to the number of times patients were hospitalized or to their current length of stay in the hospital.DiscussionThe results may help nurses to become more sensitive and responsive to factors associated with nurse‐sensitive patient outcomes of the nurse–patient relationship.ImplicationsThe nurse‐sensitive results can support nurses in designing future nurse–patient relationships.
Effects of thermal processing and temperature on the quality, protein oxidation, and structural characteristics of yak meat
Authors: Zhang Yan , Li Shengsheng , Zhao Lizhu 
Published: July 2023

AbstractThe aim of this study was to determine the effects of processing on the quality, protein oxidation, and structural properties of yak meat. The cooking loss, Warner–Bratzler shear force, meat color, texture, thiobarbituric acid reactive substance, total carbonyl content (TCC), total sulfhydryl content (TSC), and structural properties of yak meat under frying, drying, and boiling were measured. The results showed that the cooking loss rate, shear force, L* value, hardness, elasticity, and chewiness of yak meat increased (p < .05) and the a* value decreased (p < .05) with increasing central temperature after processing. Fried yak meat at 80°C had the lowest cooking loss rate of 42.21% and the lowest shear force of 50.86 N, which had better textural characteristics, followed by boiling, while the maximum cooking loss rate, hardness, and shear force were 1.40 times, 1.26 times, and 1.2 times that of frying, respectively. The thiobarbituric acid reactive substance was obtained after decoction and peaked at 1.88 ± 0.04 mmol/mg at 60°C. The highest TCC and the lowest TSC were obtained for dried proteins at 80°C. In addition, as the central temperature increased, the helical structure in the protein secondary structure decreased, the disordered structure increased, the fluorescence intensity of myofibrillar proteins decreased, and protein degradation occurred. It was concluded that dried yak meat had the highest protein oxidation and the worst quality, while fried yak meat had the lowest protein oxidation and the best quality.
Migrating eagles stopping in the Sahara Desert: Aberrant behaviour or foraging strategy?
Authors: Mellone U. , Urios V. , Chiatante G. 
Published: July 2023

AbstractThe Sahara Desert is one of the major ecological barriers of the Palearctic‐Africa bird migration system. We analysed the behaviour of GPS‐tagged booted eagles (Aquila pennata) breeding in Spain and wintering in Tropical Africa, focusing on the Sahara crossing. We searched for anomalous track segments recorded during the desert crossing, finding that non‐directional and/or slow movements occur in 35% of the migratory journeys and last up to 31 days (average: 5.9). The analyses show that this behaviour is not triggered by adverse weather conditions, and is shown especially by females during spring. The length of the stopping periods affects the arrival date to the breeding grounds only in males, which means that females buffer the potential delay with an earlier migration start, suggesting that this behaviour is followed deliberately. These wandering movements occur in hyper‐arid areas without vegetation cover. A similar behaviour has not been previously recorded in any other trans‐Saharan raptor and is probably related to the ability of booted eagles to take advantage of food resources unexploited by other predators, such as migratory songbirds stopping in the desert during the day, and migratory locusts. If confirmed by further research involving higher resolution tracking and field observations, our findings may show a new way of combining foraging and migration, without a well‐defined directed trajectory, nor stopping in a restricted spot, but instead wandering over wide areas.
Does low‐level laser therapy decrease pain and edema in patients undergoing orthognathic surgery? Systematic review and meta‐analysis
Authors: de Paula Ribeiro Borges Danilo , dos Santos Marcos Antônio Lima , da Mota Santana Lucas Alves , de Almeida Souza Liane Maciel , Takeshita Wilton Mitsunari 
Published: July 2023

AbstractAimThis systematic review purposed to investigate whether low‐level laser therapy is effective in reducing pain and edema in patients undergoing orthognathic surgery.Materials and MethodsAn electronic search was conducted in PubMed, SCOPUS, Embase, SciELO, Web of Science, LILACS, IEEE XPLORE, Google Scholar, Open Thesis, OpenGrey, and Open Access Thesis and Dissertationswith no restrictions on language or year of publication. PICOS strategy wasused to define the eligibility criteria. The risk of bias (ROB 2.0 Tool) andmethodological quality assessment was carried out, and a meta‐analysis was performed using a random‐effect model. The quality of evidence was classified with the GRADE (Grades of Recommendation, Assessment, Development, and Evaluation) classification system. The analyses were performed with Review Manager 5.3 (Cochrane IMS, Copenhagen, Denmark).ResultsA total of 1255 potentially relevant records were selected through the search strategy. After screening titles and abstracts, five full‐text manuscripts were assessed for eligibility and three randomized controlled trials (RCTs) were included in the meta‐analysis. Results favourable to low‐level laser therapy were found both for the pain outcome (p < 0.0001) and edema (p = 0.001).ConclusionConsidering the limitations of this systematic review, low‐level laser therapy showed a positive effect in reducing pain and edema in the postoperative period of bimaxillary orthognathic surgeries, with moderate and high‐quality evidence, respectively.
Ergogenic Effects of Very Low to Moderate Doses of Caffeine on Vertical Jump Performance
Authors: Matsumura Teppei , Takamura Yuki , Fukuzawa Kazushi , Nakagawa Kazuya , Nonoyama Shunya , Tomoo Keigo , Tsukamoto Hayato , Shinohara Yasushi , Iemitsu Motoyuki , Nagano Akinori , Isaka Tadao , Hashimoto Takeshi 
Published: July 2023

Although the ergogenic effects of 3–6 mg/kg caffeine are widely accepted, the efficacy of low doses of caffeine has been discussed. However, it is unclear whether the ergogenic effects of caffeine on jump performance are dose responsive in a wide range of doses. This study aimed to examine the effect of very low (1 mg/kg) to moderate doses of caffeine, including commonly utilized ergogenic doses (i.e., 3 and 6 mg/kg), on vertical jump performance. A total of 32 well-trained collegiate sprinters and jumpers performed countermovement jumps and squat jumps three times each in a double-blind, counterbalanced, randomized, crossover design. Participants ingested a placebo or 1, 3, or 6 mg/kg caffeine 60 min before jumping. Compared with the placebo, 6 mg/kg caffeine significantly enhanced countermovement jump (p < .001) and squat jump (p = .012) heights; furthermore, 1 and 3 mg/kg of caffeine also significantly increased countermovement jump height (1 mg/kg: p = .002, 3 mg/kg: p < .001) but not squat jump height (1 mg/kg: p = .436, 3 mg/kg: p = .054). There were no significant differences among all caffeine doses in both jumps (all p > .05). In conclusion, even at a dose as low as 1 mg/kg, caffeine improved vertical jump performance in a dose-independent manner. This study provides new insight into the applicability and feasibility of 1 mg/kg caffeine as a safe and effective ergogenic strategy for jump performance.
Nitrogen and sulfur cycling driven by Campylobacterota in the sediment–water interface of deep-sea cold seep: a case in the South China Sea
Authors: Sun Qing-lei , Xu Ke , Cao Lei , Du Zengfeng , Wang Minxiao , Sun Li 
Published: July 2023

ABSTRACT

Chemoautotrophs within Campylobacterota, especially
Sulfurovum
and
Sulfurimonas
, are abundant in the seawater–sediment interface of the Formosa cold seep in the South China Sea. However, the
in situ
activity and function of Campylobacterota are unknown. In this study, the geochemical role of Campylobacterota in the Formosa cold seep was investigated with multiple means. Two members of
Sulfurovum
and
Sulfurimonas
were isolated for the first time from deep-sea cold seep. These isolates are new chemoautotrophic species that can use molecular hydrogen as an energy source and CO
2
as a sole carbon source. Comparative genomics identified an important hydrogen-oxidizing cluster in
Sulfurovum
and
Sulfurimonas
. Metatranscriptomic analysis detected high expression of hydrogen-oxidizing gene in the RS, suggesting that H
2
was likely an energy source in the cold seep. Genomic analysis indicated that the
Sulfurovum
and
Sulfurimonas
isolates possess a truncated sulfur-oxidizing system, and metatranscriptomic analysis revealed that
Sulfurovum
and
Sulfurimonas
with this genotype were active in the surface of RS and likely contributed to thiosulfate production. Furthermore, geochemical and
in situ
analyses revealed sharply decreased nitrate concentration in the sediment–water interface due to microbial consumption. Consistently, the denitrification genes of
Sulfurimonas
and
Sulfurovum
were highly expressed, suggesting an important contribution of these bacteria to nitrogen cycling. Overall, this study demonstrated that Campylobacterota played a significant role in the cycling of nitrogen and sulfur in a deep-sea cold seep.

IMPORTANCE

Chemoautotrophs within Campylobacterota, in particular
Sulfurovum
and
Sulfurimonas
, are ubiquitous in deep-sea cold seeps and hydrothermal vents. However, to date, no
Sulfurovum
or
Sulfurimonas
has been isolated from cold seeps, and the ecological roles of these bacteria in cold seeps remain to be investigated. In this study, we obtained two isolates of
Sulfurovum
and
Sulfurimonas
from Formosa cold seep, South China Sea. Comparative genomics, metatranscriptomics, geochemical analysis, and
in situ
experimental study indicated collectively that Campylobacterota played a significant part in nitrogen and sulfur cycling in cold seep and was the cause of thiosulfate accumulation and sharp reduction of nitrate level in the sediment–water interface. The findings of this study promoted our understanding of the
in situ
function and ecological role of deep-sea Campylobacterota.
Global analyses of biosynthetic gene clusters in phytobiomes reveal strong phylogenetic conservation of terpenes and aryl polyenes
Authors: Mukherjee Arijit , Tikariha Hitesh , Bandla Aditya , Pavagadhi Shruti , Swarup Sanjay 
Published: July 2023

ABSTRACTThere are gaps in our understandings on how did the evolutionary relationships among members of the phytobiomes shape their ability to produce tremendously complex specialized metabolites under the influence of plant host. To determine these relationships, we investigated the phylogenetic conservation of biosynthetic gene clusters (BGCs) on a global collection of 4,519 high-quality and nonredundant (out of 12,181) bacterial isolates and metagenome-assembled genomes from 47 different plant hosts and soil, by adopting three independent phylogenomic approaches (D-test, Pagel’s λ, and consenTRAIT). We report that the BGCs are phylogenetically conserved to varying strengths and depths in their different classes. We show that the ability to produce specialized metabolites qualifies as a complex trait, and the depth of conservation is equivalent to ecologically relevant complex microbial traits. Interestingly, terpene and aryl polyene BGCs had the strongest phylogenetic conservation in the phytobiomes, but not in the soil microbiomes. Furthermore, we showed that terpenes are largely uncharacterized in phytobiomes and pinpointed specific clades that harbor potentially novel terpenes. Taken together, this study sheds light on the evolution of specialized metabolites’ biosynthesis potential in phytobiomes under the influence of plant hosts and presents strategies to rationally guide the discovery of potentially novel classes of metabolites.IMPORTANCEThis study expands our understandings of the biosynthetic potential of phytobiomes by using such worldwide and extensive collection of microbiomes from plants and soil. Apart from providing such vital resource for the plant microbiome researchers, this study provides fundamental insights into the evolution of biosynthetic gene clusters (BGCs) in phytobiomes under the influence of plant host. Specifically, we report that the strength of phylogenetic conservation in microbiomes varies for different classes of BGCs and is influenced as a result of plant host association. Furthermore, our results indicate that biosynthetic potential of specialized metabolites is deeply conserved equivalent to other complex and ecologically relevant microbial traits. Finally, for the most conserved class of specialized metabolites (terpenes), we identified clades harboring potentially novel class of molecules. Future studies could focus on plant–microbe coevolution and interactions through specialized metabolites building upon these findings.
Zircon age spectra to quantify magma evolution
Authors: Schmitt A.K. , Sliwinski J. , Caricchi L. , Bachmann O. , Riel N. , Kaus B.J.P. , Cisneros de Léon A. , Cornet J. , Friedrichs B. , Lovera O. , Sheldrake T. , Weber G. 
Published: July 2023

Abstract
The past decades have seen tremendous advances in analytical capabilities regarding the sensitivity, spatial selectivity, and instrumental precision of U-Th-Pb zircon geochronology. Along with improved zircon pretreatment to mitigate the effects of Pb-loss, these advancements have resulted in the emergence of U-Th-Pb dating as the most widely used geochronometer. In parallel, it became increasingly obvious that modern analytical techniques can resolve zircon age dispersal beyond instrumental uncertainties and that this dispersion cannot be attributed to Pb-loss or inheritance. Hence, there is a pressing need to refine statistical procedures for displaying and interpreting dispersed age data from volcanic and plutonic rocks, where zircon ages were traditionally assigned to the quasi-instantaneous events of eruption and magma emplacement, respectively. The ability to resolve zircon age spectra, which often range over timescales of 103–106 years, also offers new opportunities to monitor magmatic processes, because zircon crystallization directly relates to the temperature and composition of its host melt. This relation is, at least for typical subalkaline melt compositions, well calibrated by multiple zircon saturation experiments, although absolute saturation temperatures derived from them can vary by tens of degrees. Moreover, zircon saturation thermometry is supported by the trace element and isotopic inventory of zircon, which records the thermochemical and compositional evolution of melts at high fidelity. Here, we first review the properties of true zircon age spectra that are defined by a statistically robust overdispersion relative to analytical uncertainties. Secondly, we evaluate existing models and present new models that aim to quantitatively translate the properties of zircon age spectra into parameters controlling the longevity and thermal evolution of crustal magma bodies such as magma recharge flux and duration. These developing approaches, which aspire to capture all processes that affect the formation and dispersal of zircon in dynamic crustal magma systems, have the potential to foster an improved understanding of magmatism with implications for volcanic hazard assessment, geothermal energy uses, and the origins of ore deposits.
Therapeutic value of first versus supplemental indications of drugs in US and Europe (2011-20): retrospective cohort study
Authors: Vokinger Kerstin N , Glaus Camille E G , Kesselheim Aaron S , Serra-Burriel Miquel , Ross Joseph S , Hwang Thomas J 
Published: July 2023

Abstract

Objective
To analyze the therapeutic value of supplemental indications compared with first indications for drugs approved in the US and Europe.

Design
Retrospective cohort study.

Setting
New and supplemental indications approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) between 2011 and 2020.

Main outcome measures
Proportion of first and supplemental indications rated as having high therapeutic value using ratings from the French and German national, independent health authorities.

Results
The cohort study included 124 first and 335 supplemental indications approved by the FDA and 88 first and 215 supplemental indications approved by the EMA between 2011 and 2020; the largest subset was for cancer disorders. Therapeutic ratings were available for 107 (86%) first and 179 (53%) supplemental indications in the US and for 87 (99%) first and 184 (86%) supplemental indications in Europe. Among FDA approved indications with available ratings, 41% (44/107) had high therapeutic value ratings for first indications compared with 34% (61/179) for supplemental indications. In Europe, 47% (41/87) of first and 36% (67/184) of supplemental indications had high therapeutic value ratings. Among FDA approvals, when the sample was restricted to the first three approved indications, second indication approvals were 36% less likely to have a high value rating (relative ratio 0.64, 95% confidence interval 0.43 to 0.96) and third indication approvals were 45% less likely (0.55, 0.29 to 1.01) compared with the first indication approval. Similar findings were observed for Europe and when weighting by the inverse number of indications for each drug.

Conclusions
The proportion of supplemental indications rated as having high therapeutic value was substantially lower than for first indications. When first or supplemental indications do not offer added therapeutic value over other available treatments, that information should be clearly communicated to patients and physicians and reflected in the price of the drugs.
Global and regional burden of attributable and associated bacterial antimicrobial resistance avertable by vaccination: modelling study
Authors: Kim Chaelin , Holm Marianne , Frost Isabel , Hasso-Agopsowicz Mateusz , Abbas Kaja 
Published: July 2023

IntroductionAntimicrobial resistance (AMR) is a global health threat with 1.27 million and 4.95 million deaths attributable to and associated with bacterial AMR, respectively, in 2019. Our aim is to estimate the vaccine avertable bacterial AMR burden based on existing and future vaccines at the regional and global levels by pathogen and infectious syndromes.MethodsWe developed a static proportional impact model to estimate the vaccination impact on 15 bacterial pathogens in terms of reduction in age-specific AMR burden estimates for 2019 from the Global Research on Antimicrobial Resistance project in direct proportion to efficacy, coverage, target population for protection, and duration of protection of existing and future vaccines.ResultsThe AMR burden avertable by vaccination in 2019 was highest for the WHO Africa and South-East Asia regions, for lower respiratory infections, tuberculosis, and bloodstream infections by infectious syndromes, and forMycobacterium tuberculosisandStreptococcus pneumoniaeby pathogen. In the baseline scenario for vaccination of primary age groups against 15 pathogens, we estimated vaccine-avertable AMR burden of 0.51 (95% UI 0.49–0.54) million deaths and 28 (27–29) million disability-adjusted life-years (DALYs) associated with bacterial AMR, and 0.15 (0.14–0.17) million deaths and 7.6 (7.1–8.0) million DALYs attributable to AMR globally in 2019. In the high-potential scenario for vaccination of additional age groups against seven pathogens, we estimated vaccine-avertable AMR burden of an additional 1.2 (1.18–1.23) million deaths and 37 (36–39) million DALYs associated with AMR, and 0.33 (0.32–0.34) million deaths and 10 (9.8–11) million DALYs attributable to AMR globally in 2019.ConclusionIncreased coverage of existing vaccines and development of new vaccines are effective means to reduce AMR, and this evidence should inform the full value of vaccine assessments.