bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual minority women are at greater risk of depressive symptoms: the mediation effects of minority stressors
Authors: Li Jiayu , Xiao Chenchang , Zhai Mengxi , Yuan Liang , Liu Dan , Liu Xin , Yu Bin , Yang Hong 
Published: February 2023

Abstract
Background
Although, a substantial amount of research has shown that compared with heterosexual counterparts, sexual minority populations are at increased risk of mental health symptoms, there are less public health researches on lesbian and bisexual women, making it hard to draw conclusions about the way to improve health.
Methods
This study examined the association of distal stressors, proximal stressors with depressive symptom. The study sample included 301 sexual minority women in Beijing, with 81.4% identifying as lesbian and 18.6% identifying as bisexual. They responded to self-report measures of sexual minority stress and depressive symptoms. Data were collected from August 2018 to October 2018. The association of minority stressors and depressive symptoms was estimated using the parallel mediation models.
Results
Depressive symptoms were prevalent among sexual minority women (56.1%). The correlations between distal stressors, proximal stressors and depressive symptoms were significant. The parallel mediation model showed that, expectation of rejection rather than sexual orientation concealment and internalized homophobia emerges as a significant mediator between sexual orientation-related stigma and depressive symptoms.
Conclusions
Early intervention addressing sexual orientation-related stigma combined with eliminating expectation of rejection would help prevent depressive symptoms in sexual minority women.
Efficacy of Spinal Tuinan combined with Microneedle knife in the treatment of neurogenic cervical spondylosis: study protocol for a randomized controlled trial
Authors: Fu Liying , Lv Huijuan , Wang Hailiang , Li Zhengxiang 
Published: February 2023

Abstract
Background
Neurogenic cervical spondylosis(NCS) is the most common type of cervical spondylosis, accounting for approximately 60 percent. Our research team has accumulated rich clinical experience in the treatment of cervical spondylosis and has carried out research related to manipulation and acupuncture therapies. This project further develops scientific research on neurogenic cervical spondylosis based on previous studies. A randomized controlled study was conducted on spinal tuina, microneedle knife, and spinal tuina combined with microneedle knife. We will observe the changes in clinical symptoms and imaging findings in patients with neurogenic cervical spondylosis by the three treatments, and evaluate the clinical efficacy and adverse reactions of the three treatments. There is great significance in guiding the clinical treatment of neurogenic cervical spondylosis.
Methods
This is a single-site, single-blind, randomized, controlled trial. A total of 90 participants will be randomly allocated to the Spinal Tuina group (Group A), Microneedle knife group (Group B) or Spinal Tuina combined with Microneedle knife group (Group C) in a 1:1:1 ratio. Patients will receive three acupuncture treatment sessions per week for 2 consecutive weeks. All patients will then receive a 4-week follow-up. Primary outcome is the effective rate. The secondary outcomes are the amount of improvement in trapezius muscle tone, the Neck Disability Index score, the Visual Analogue Score(VAS), and the cervical curvature values. Adverse events will be monitored in the treatment period and follow-up period.
Discussion
This trial may provide high-quality evidence for the efficacy and safety of Spinal Tuinan combined with Microneedle knife for NCS. The results of this study will be published in peer-reviewed journals.
Trial registration
Chinese Clinical Trial Registry ChiCTR2200061381. Registered on 7 June 2022.
RNA quality assessment of long-term storage biobank samples from colorectal cancer patients for sequencing and profiling
Authors: Suwatthanarak Thanawat , Acharayothin Onchira , Thanormjit Kullanist , Chaiboonchoe Amphun , Suwatthanarak Tharathorn , Niyomchan Apichaya , Pithukpakorn Manop , Chinswangwatanakul Vitoon , Tanjak Pariyada 
Published: February 2023

Abstract
Samples from patients with colorectal cancer (CRC) are valuable tools for understanding the development, progression, and treatment of the disease. However, to date, the integrity of long-term preserved human specimens in biobanks has not been well understood. In this study, we investigated the RNA quality of 12-year-stored specimens, including frozen and formalin-fixed, paraffin-embedded (FFPE) tumor tissues from CRC patients at the Siriraj Biobank. We assessed the RNA quality of 12-year and 2-year storage samples using three technologies: next-generation sequencing (NGS), Nanostring nCounter® platform, and GeoMx® digital spatial profiling (DSP). We found that the RNA quality of 12-year storage frozen tissues was consistent with the criteria for RNA sequencing. Although RNA in long-term storage FFPE tissues was degraded, the normalized counts of RNA from the 12-year-stored FFPE samples were comparable to those from the 2-year-stored FFPE samples in the Nanostring nCounter® gene expression assay. For histological staining, clear tissue microanatomy was observed in the FFPE blocks stored for 12 years. In GeoMx® DSP, there was no statistically significant difference in the normalized counts of RNA from the 12- and 2-year stored FFPE samples. Our results suggest the potential utilization of long-term storage biobank specimens from patients with CRC for NGS, Nanostring nCounter® gene expression analysis, and GeoMx® DSP.
Tunable multistate field-free switching and ratchet effect by spin-orbit torque in canted ferrimagnetic alloy
Authors: Hsu Cheng-Hsiang , Gross Miela , Kleidermacher Hannah , Sayed Shehrin , Salahuddin Sayeef 
Published: February 2023

Abstract

Spin-orbit torque is not only a useful probe to study manipulation of magnetic textures and magnetic states at the nanoscale but also it carries great potential for next-generation computing applications. Here we report the observation of rich spin-orbit torque switching phenomena such as field-free switching, multistate switching, memristor behavior and ratchet effect in a single shot, co-sputtered, rare earth-transition metal GdxCo100−x. Notably such
effects have only been observed in antiferromagnet/ferromagnet bi-layer systems previously. We show that these effects can be traced to a large anistropic canting, that can be engineered into the GdxCo100−x system. Further, we show that the magnitude of these switching phenomena can be tuned by the canting angle and the in-plane external field. The complex spin-orbit torque switching observed in canted GdxCo100−x not only provides a new platform for novel spintronics but also serves as a model system to study the underlying physics of complex magnetic textures and interactions.
Global Reporting Initiatives and Firm Performance: A Stakeholder’s Perspective in Indian Companies
Authors: Agrawal Rajat , Arora Sanjeev , Arora Gitika 
Published: February 2023

Abstract

With the growth of the corporate sector, there is a simultaneous increase in the external forces that pressurize the corporate sector to practice socially responsible behavior. Based on this, the practice of reporting sustainable activities is being used by companies in different manners by different countries. In view of this, the purpose of the study is to empirically analyze the financial performance of sustainability reporting and non-reporting companies from the stakeholder’s perspective.The study is longitudinal, covering a time span of 22 years. The parameters of the financial performance are categorized and statistically analyzed based on the stakeholders considered under the study. Based on the analysis, the study has found no evidence of difference in the financial performance between sustainability reporting and non-reporting companies from the stakeholder’s perspective.The paper has contributed to the literature by analyzing the financial performance of companies from the stakeholder’s perspective through the longitudinal study.
Turnkey photonic flywheel in a Chimera cavity
Authors: Nie Mingming , Jia Kunpeng , Bartos Jan , Zhu Shining , Xie Zhenda , Huang Shu-Wei 
Published: February 2023

Abstract
Dissipative Kerr soliton (DKS) microcomb has emerged as an enabling technology that revolutionizes a wide range of applications in both basic science and technological innovation. Reliable turnkey operation with sub-optical-cycle and sub-femtosecond timing jitter is key to the success of many intriguing microcomb applications at the intersection of ultrafast optics and microwave electronics. Here we propose a novel approach to demonstrate the first turnkey Brillouin-DKS frequency comb. Our approach with a Chimera cavity offers essential benefits that are not attainable previously, including phase insensitivity, self-healing capability, deterministic selection of DKS state, and access to the ultralow noise comb state. The demonstrated turnkey Brillouin-DKS frequency comb achieves a fundamental comb linewidth of 100 mHz and DKS timing jitter of 1 femtosecond for averaging times up to 56 µs. The approach is universal and generalizable to various device platforms for user-friendly and field-deployable comb devices.
Mobile Money and Financial Inclusion: The role of Institutional Quality
Authors: Bawuah Isaac 
Published: February 2023

Abstract

This paper investigates the role of institutional quality in the relationship between mobile money and financial inclusion in Ghana from 2014 to 2021. It uses annual data from Ghana on a bundle of four financial inclusion variables, six institutional quality indicators (i.e., rule of law, governance efficiency, control of corruption, voice and accountability, regulatory quality and political stability), and total volume of mobile money transaction in a year. The baseline regression was employed. The empirical results reveal that institutional quality and mobile money have direct impact on financial inclusion. Also, institutional quality plays positive and significant role in the relationship between mobile money and financial inclusion. Mobile phone subscription, financial development, inflation and GDPGR influence financial inclusion.
Prevalence of Compassion Fatigue, Burnout, Compassion Satisfaction, and Associated Factors among nurses working in cancer treatment centers Ethiopia
Authors: Mirutse Almaz , Mengistu Zuriyash , Bizuwork Ketema 
Published: February 2023

Abstract

Background: Overuse of compassionate care to those under the care may lead to compassion fatigue and burnout. In Ethiopia, there is limited study on the positive outcome of compassionate care known as Compassion Satisfaction and the negative consequences have been described in terms of Compassion Fatigue and Burnout. Therefore, it is important to assess the negative and positive effects of compassionate care.
Objective:Prevalence of Compassion Fatigue, Burnout, Compassion Satisfaction, and Associated Factors among Nurses Working in Cancer Treatment Centers in Ethiopia
Methods: Institution-based quantitative cross-sectional design was conducted in five randomly selected public hospitals in Ethiopia, from May to April 2020. All the nurses who were working in the cancer treatment centers of the five hospitals were included in the study. Data were collected using a standard self-administer questionnaire and the data were analyzed by using the SPSS 21version. Descriptively: frequency, mean, standard deviation, and inferential statistics: Bi-variate and multiple logistic regression analysis were computed to measure the association of variables with compassion fatigue. Confidentiality was maintained.
Result: The majority of respondents 154 (67.0%) were female. The age of the participants ranges from 20 to 65 (32.06 + 7.45) years. The mean (SD) scores for the dimensions of compassion satisfaction, burnout, and compassion fatigue were 34.41 (6.74), 27.70 (4.24), and 35.83 (7.78) respectively. This study revealed that male nurses had lower compassion satisfaction than female nurses (P = 0.007). Neuroticism personality trait had positivity associated with compassion fatigue (P = 0.001). Nurses who received low monthly income had significantly lower scores for compassion fatigue (P = 0.002). Social support was the strongest predictor of compassion satisfaction. We found that personality agreeableness, consciousness, and openness personality had significant associations with compassion satisfaction (P< 0.035).
Conclusion: In general the study found high compassion fatigue and low compassion satisfaction. Further, being male, having low income and neuroticism personality were associated with compassion fatigue, while agreeableness, consciousness, and openness personality were associated with compassion satisfaction. Therefore, attention should be given to nurses working in cancer centers to ensure positive energy.
RNA-Seq, co-expression network and eQTL analysis identify key genes for chlorophyll and carbon metabolism in rice
Authors: Nehra Mamta , Kaul Tanushri , Jadhav Sagar Sudam , Bharti Jyotsna , Sony Sonia Khan 
Published: February 2023

Abstract
Leaf color mutations are excellent research tools for understanding the mechanics of pigment metabolism, chloroplast development, and photosynthesis. Chloroplasts and photosynthetic pigments in leaf cells of plants both play a significant role in determining the photosynthetic efficiency, as well as crop productivity to a greater extent. Leaf color has been regarded as an essential agronomic trait in rice (Oryza sativa L.) majorly because any changes in leaf color have an impact on rice yield. In this study, M-507, a green-revertible albino mutant of Nagina 22 (N22), was characterized and compared to wild-type in terms of anatomical, physiological, and molecular similarities. The mutant showed significantly lower chlorophyll content, defective chloroplast morphology, and reduced photosynthetic capacity than the wild-type. The differentially expressed genes (DEGs) were identified in M-507 with respect to wild-type using high-throughput transcriptome sequencing revealed downregulation of genes essential for the synthesis of chlorophyll, carotenoid, anthocyanin, and photosynthesis pathway. Whereas, genes associated with chlorophyll degradation, ion transport, and starch and sucrose metabolism were remarkably up-regulated in M-507. Co-expression networking revealed a substantial positive correlation between the expression profiles of the chloroplastic genes, transcription factors, and the genes involved in pigment metabolism and starch and sucrose metabolism. Furthermore, sequence similarity analysis revealed existing single-nucleotide polymorphism (SNP) and Insertions and Deletions (InDels) in M-507 as compared to N22. The identified SNPs and InDels candidate genes have been found to have strong associated positive and negative expression quantitative trait loci (eQTLs). Additionally, transcription factor family genes, including NAC, bHLH, WRKY, AP2/ERF, and MYB, were also identified. Real-time quantitative PCR (qPCR) was used to confirm the reliability of RNA sequencing results. These findings provide a possible pathway for the molecular mechanism associated with leaf color formation as well as a valuable resource for molecular marker development, that will be critical for improving rice crop production efficiency.
Simultaneous Monitoring of ppmv Level Methane and ppbv Level VOCs Near Industrial Sources Using a Real-Time GC
Authors: Jian Rih-Sheng , Chu Junn-An , Song Lung-Yu , Lo Ei-Wen , Lu Chia-Jung 
Published: February 2023

Abstract
This paper presents the design and field monitoring results using a compact gas chromatograph equipped with a novel tandem sampler that enables the simultaneous and continuous analyses of methane at ppmv level and multiple volatile organic compounds (VOCs) at ppbv level. The tandem sampler consists of a capillary preconcentrator filled with multistage adsorbents and a subsequent sampling loop. In this system, ambient methane breakthroughs the adsorbents and fills the sampling loop while the ppbv levels of VOCs are preconcentrated by adsorbents. The field study was conducted in a developing industrial area near a midsize township that was surrounded by paddy fields. Continuous analysis data provided in 25 min intervals revealed the independent sources of various industrial chemicals. The rapid analysis capability of this instrument can establish concentration distribution patterns within only a few days of field study. Right skewed concentration distributions of low ppbv VOCs and a symmetrical Gaussian distribution of methane at ppmv using this single near real-time GC instrument. This study describes the development of a fast and cost-effective method to simultaneously assess the real-time variations in VOCs and methane in general environments.
How forest management changed the course of the Washburn fire and the fate of Yosemite’s giant sequoias
Authors: Hankin Lacey , Dickman Garrett , Anderson Chad , Bevington Parker , Stephens Scott Lewis 
Published: February 2023

Abstract

Background
The Washburn fire started on July 7, 2022 in the lower Mariposa Grove in Yosemite National Park, posing immediate threats to the iconic giant sequoias, critical Pacific fisher habitat, and the community of Wawona and bringing national attention to Yosemite’s firefighting efforts. In the aftermath of the Washburn, we evaluate how decades of fire management and recent roadside thinning in the Park shaped the tactics and outcomes of the Washburn fire. Fuels reduction and prescribed fire have been at the core of Yosemite’s fire management program since the 1970s and much of this activity has been concentrated in the two areas where firefighting operations were most successful in protecting key resources. We use long-term fire effects monitoring data, airborne light detection and ranging data, and operational perspectives to link together science, management, and fire operations.
Results
Successful initial attack and suppression efforts kept fire out of the Mariposa Grove and the community, where topography and the distribution of heavy fuels largely drove fire behavior throughout the course of the fire. We demonstrate the cumulative effects of decades of fuels treatments in reducing two major drivers of fire behavior – tree density and fuel load – and highlight substantially lower ladder fuels in treatment units compared to the Washburn fire footprint.
Conclusions
We show how repeated prescribed fire and fuels treatments can promote forest structure indicative of frequent-fire regimes, moderate extreme fire behavior, improve the ability to protect key resources of concern, and increase human safety in the face of unplanned wildfire. Strategically placed prescribed fire and fuels treatments surrounding the Washburn Fire were key considerations in wildfire suppression tactics and were instrumental in protecting the Mariposa Grove.
Disease progression patterns of brain morphology in schizophrenia: More progressed stages in treatment-resistance
Authors: nakajima shinichiro , Sone Daichi , Young Alexandra , Shinagawa Shunichiro , Tsugawa Sakiko , Iwata Yusuke , Tarumi Ryosuke , Ogyu Kamiyu , Honda Shiori , Ochi Ryo , Matsushita Karin , Ueno Fumihiko , Hondo Nobuaki , Koreki Akihiro , Torres-Carmona Edgardo , Mar Wanna , Chan Nathan , Koizumi Teruki , Kato Hideo , Kusudo Keisuke , De Luca Vincenzo , Gerretsen Philip , Remington Gary , Onaya Mitsumoto , Noda Yoshihiro , Uchida Hiroyuki , Mimura Masaru , Shigeta Masahiro , Graff-Guerrero Ariel 
Published: February 2023

Abstract
Given the heterogeneity and possible disease progression in schizophrenia, identifying the neurobiological subtypes and progression patterns in each patient may lead to the development of clinically useful biomarkers. In this cross-sectional study, we adopted data-driven machine-learning techniques to classify and stage the progression patterns of brain morphological changes in schizophrenia and investigate the association with treatment resistance. We included 177 patients with schizophrenia, characterized by treatment response or resistance, with 3D T1-weighted magnetic resonance imaging from 3 institutions. Cortical thickness and subcortical volumes calculated by FreeSurfer were converted into Z-scores using 73 healthy controls data. The Subtype and Stage Inference (SuStaIn) algorithm was used for unsupervised machine-learning classification and staging. As a result, SuStaIn identified three different subtypes: 1) subcortical volume reduction (SC) type (73 patients, 47.4%), in which volume reduction of subcortical structures occurs first and moderate cortical thinning follows, 2) globus pallidus hypertrophy and cortical thinning (GP-CX) type (42 patients, 27.3%), in which globus pallidus hypertrophy initially occurs followed by progressive cortical thinning, 3) cortical thinning (pure CX) type (39 patients, 25.3%), in which thinning of the insular and lateral temporal lobe cortices primarily happens. The remaining 23 patients were assigned to baseline stage of progression (no change). SuStaIn also found 84 stages of progression, and treatment-resistant schizophrenia showed significantly more progressed stages of progression than treatment-responsive cases (p=0.001). The GP-CX type presented in earlier stages than the pure CX type (p=0.009). In conclusion, the brain morphological progressions in schizophrenia can be classified into three subtypes by SuStaIn algorithm. Treatment resistance was associated with more progressed stages of the disease, which may suggest a novel biomarker for schizophrenia.
ApoE Alzheimer’s Disease Aβ-amyloid plaque morphology varies according to APOE isotype
Authors: Caesar Ina , Nilsson K Peter R , Hammarstrom Per , Lindgren Mikael , Prokop Stefan , Heppner Frank L , Schmeidler James , Haroutunian Vahram , Holtzman David M , Hof Patrick R , Gandy Sam 
Published: February 2023

Abstract
Background: The apolipoprotein E (APOE, gene; apoE, protein) ε4 allele is the most common identified genetic risk factor for typical late-onset sporadic Alzheimer’s disease (AD). Each APOE ε4 allele roughly triples the relative risk for AD compared to that of the reference allele, APOE ε3.
Methods: We have employed hyperspectral fluorescence imaging with an amyloid-specific, conformation-sensing probe, p-FTAA, to elucidate protein aggregate structure and morphology in fresh frozen prefrontal cortex samples from human postmortem AD brain tissue samples from patients homozygous for either APOE ε3 or APOE ε4.
Results: As expected APOE ε4/ε4 tissues had significantly larger load of CAA than APOE ε3/ε3. APOE isoform-dependent morphological differences in amyloid plaques were also observed. Amyloid plaques in APOE ε3/ε3 tissue had small spherical cores and large corona while amyloid plaques in APOE ε4/ε4 tissues had large irregular and multi-lobulated plaques with relatively smaller corona. Despite the different morphologies of their cores, the p-FTAA stained APOE ε3/ε3 amyloid plaque cores had spectral properties identical to those of APOE ε4/ε4 plaque cores.
Conclusions: These data support the hypothesis that one mechanism by which the APOE ε4 allele affects AD is by modulating the macrostructure of pathological protein deposits in brain. APOE ε4 is associated with a higher density of amyloid plaques (as compared to APOE ε3). We speculate that multilobulated APOE e4-associated plaques arise from multiple initiation foci that coalesce as the plaques grow.