bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of 8-diff clinical blood testing of patients to assess the severity of the new coronavirus infection
Authors: Slesareva T. A. , Gruzdeva O. V. , Tarasova O. L. , Kuzmina A. A. , Alekseenko A. V. , Dyleva Yu. A. , Dolinchik T. R. , Bazdyrev E. D. , Gofman L. S. , Barbarash O. L. 
Published: January 2023

Introduction. A new coronavirus infection causes a variety of changes in the body of an infected person, which can be monitored using clinical blood analysis. The capabilities of flow cytometry allow to expanding the range of analyzed cell populations, which gives a more complete picture of the patient’s condition and the course of infection process.Aim. To study the extended 8-diff clinical blood analysis in patients with COVID-19 and to identify the parameters characterizing a severe course and an unfavorable outcome.Material and Methods. The study group comprised 282 patients with a confirmed diagnosis of a new coronavirus infection. The following parameters of the extended 8-diff clinical blood test were evaluated: the total content of leukocytes and their populations, the number of reactive and antibody-synthesizing lymphocytes (RE-LYMPH, AS-LYMPH), indicators characterizing the reactivity and granularity of neutrophils (NEUT-RI, NEUT-GI), erythrocyte count, hemoglobin level, normoblast count, and platelet count. Statistical data were processed using the Statistica 10.0 software.Results. The blood picture of patients with a severe course of COVID-19 as well as of those with an unfavorable outcome of disease was characterized by neutrophilia, normoblastemia, and an increase in the number of immature granulocytes. At the same time, there was a significant decrease in the number of lymphocytes and monocytes below the reference interval and a decrease in the number of eosinophils to the extent of complete absence. The performed logistic regression analysis allowed to determine the most significant hematological parameters in predicting the outcome of COVID-19 as follows: the total number of leukocytes (OR 1.3), neutrophils (OR 2.1), reactive neutrophils (OR 1.3), eosinophils (OR 0.05), monocytes (OR 0.2), lymphocytes (OR 0.4), and neutrophil-to-lymphocyte ratio (NLR) (OR 1.4). Also, the threshold values were established for these parameters as follows: the total number of leukocytes > 7.2 × 109/L, neutrophils > 5 × 109/L, reactive neutrophils > 48.6 Fi, eosinophils < 0.05 × 109/L, lymphocytes < 1.3 × 109/L, monocytes < 0.5 × 109/L, and NLR > 2.9 were associated with an unfavorable outcome of the disease.Conclusion. The obtained data may be used for a comprehensive evaluation of COVID-19 patient condition along with other laboratory markers of the severe course of the infection.
Analysis of lethal outcomes in COVID-19 convalescents in multidisciplinary hospital
Authors: Korneva Yu. S. , Michurina A. P. 
Published: January 2023

Health status of COVID-19 convalescents poses a serious burden on the healthcare system due to frequent decompensation of existing diseases and high mortality after episode of infection. This requires an analysis of not only the causes of death, but also the time of occurrence of complications in order to implement preventive measures and potentially reduce mortality Aim. The aim of the study was to carry out a clinical and pathoanatomical analysis of fatal outcomes in convalescents of COVID-19 in a multidisciplinary hospital.Material and Methods. The medical documentation of 67 deceased patients with a documented history of COVID-19 was analyzed. Patients were divided into five groups based on the nosological principle.Results. The study showed that the absolute majority of fatal outcomes occurred within one to two months (chi2 = 15.53; p = 0.001; df = 1); after that, the mortality rate gradually decreased over time. The rate of patients who died from acute and chronic decompensated cardiac diseases was 63%, which may be attributed to the specifics of the hospital. The number of neglected oncological diseases was 21% in our sample, which also should be considered a negative impact of the pandemic. In our study, the neglected oncological diseases were observed in 45% of patients, which was probably due to the profile of the hospital. The incidence rate of pulmonary embolism and other thrombotic complications was significantly higher in women (chi2 = 30.73; p < 0.001; df = 1). While comparing the time between recovery from COVID-19 and onset of death, we found that thrombotic complications occurred more often either immediately or within one to two months after recovery from COVID-19; sometimes patients already had a formed lung infarction, but in these cases the interval was longer (four to six months), which suggested the beginning of thrombosis during the acute stage of disease.Conclusion. At the early stage, it is necessary to analyze basic information about the epidemiology of post-COVID-19 syndrome taking into account patient age and comorbidities. Given the high frequency of deaths, most often associated with thrombotic events or disorders of the cardiovascular system, it is necessary to plan clinical and laboratory tests, appropriate registries and clinical trials in order to properly assess thee risks and prepare for the long-term consequences of COVID-19.
Clinical and echocardiographic profile of patients one year after COVID-19 pneumonia depending on the left ventricular global longitudinal strain
Authors: Yaroslavskaya E. I. , Krinochkin D. V. , Shirokov N. E. , Gorbatenko E. A. , Gultyaeva E. P. , Garanina V. D. , Krinochkina I. R. , Korovina I. O. , Osokina N. A. , Migacheva A. V. 
Published: January 2023

Background. Studying the impact of complicated course of new coronavirus infection on the cardiovascular system in the long term after patient discharge from hospital is of high significance.Purpose. To compare the clinical and echocardiographic parameters of persons with history of verified COVID-19 pneumonia one year after discharge from hospital depending on the value of left ventricular (LV) global longitudinal strain (GLS).Material and Methods. A total of 116 patients (50.4% men) aged 49.0 ± 14.4 years (from 19 to 84 years) with history of verified COVID-19 pneumonia were examined one year ± three weeks after discharge. The parameters of left ventricular global and segmental longitudinal strain were studied in 80 patients with optimal quality of echocardiographic visualization. Patients were divided into groups depending on the LV GLS value: group 1 included 35 patients with normal LV GLS (<–20%); group 2 comprised 45 patients with impaired LV GLS (≥–20%). The groups did not differ in age (p = 0.145), severity of lung injury during hospitalization (p = 0.691), duration of hospitalization (p = 0.626), and frequency of stay in the intensive care unit (p = 0.420).Results. Abnormal values of LV GLS one year after discharge were found in 57.5% of patients with optimal visualization quality while the LV ejection fraction (EF) was normal in all patients. The majority of patients in group 2 were men (71.1% vs 28.6%, p < 0.001). A combination of coronary artery disease (CAD) and hypertension (AH) was more often diagnosed in this group (22% vs 6%, p = 0.040). The values of LV EF did not differ between the groups. The values of LV GLS were significantly worse in patients of group 2 (–17.6 ± 1.9% vs –21.8 ± 1.2%, p < 0.001). Moreover, the parameters of diastolic function including the left atrial emptying volume index (1.3 ± 0.3 mL/m2 vs 1.4 ± 0.3 mL/m2, р = 0.052) and velocity of the lateral part of the mitral valve fibrous ring e’ (10.8 ± 4 .4 cm/s vs 12.8 ± 4.0 cm/s, p = 0.045) were also lower in this group.Conclusions. The LV GLS was impaired in 57.5% patients with normal LV EF one year after COVID-19 pneumonia. In the group with impaired LV GLS, men predominated; coronary artery disease was more often detected in combination with AH; and parameters of LV diastolic function were worse compared with the corresponding parameters in the group of patients with normal LV GLS.
Features of COVID-19 in patients with chronic obstructive pulmonary disease, bronchial asthma, and cardiovascular comorbidity
Authors: Samoylov K. V. , Bukreeva E. B. , Boyarko V. V. , Gereng E. A. 
Published: January 2023

Aim. The aim of the study was to identify the features of a new coronavirus infection in patients with chronic obstructive pulmonary disease (COPD), bronchial asthma (BA), and cardiovascular disease (CVD).Materials and Methods. The retrospective study included 58 patients with novel coronavirus infection, which were divided into four groups: group 1 comprised 12 patients with COPD and CVD; group 2 comprised 15 patients with BA and CVD; and group 3 comprised 31 patients with CVD only. All patients underwent a clinical examination, complete blood count, biochemical blood examination, coagulation testing, serum ferritin test, and multi-slice computed tomography.Results. The severity of dyspnea was greater in patients with COPD/CVD compared with BA/CVD, and in patients without bronchopulmonary pathology. The frequency of desaturation was the lowest in BA/CVD group compared with COPD/CVD and COPD/BA/CVD. A lower level of saturation was observed in COPD/CVD group in comparison with BA/CVD. The extent of lung damage also prevailed in group with COPD/CVD compared with patients without bronchopulmonary pathology. Patients with CVD only demonstrated the lowest level of leukocytes in contrast with all other study groups. However, the platelet count prevailed in the CVD group compared with the COPD/CVD group. Serum ferritin in patients with COPD/CVD was higher than in the AD/CVD group.Conclusion. Patients with COPD had more severe coronavirus infection due to severity of dyspnea, low saturation indicators, high values of ferritin, and greater severity of lung damage according to computed tomography. Patients with asthma were prone to a less severe course of coronavirus infection due to less dyspnea, rare episodes of desaturation, high saturation rates, and low ferritin values.
Remodeling of the right heart and hepatolienal circulation in patients with coronavirus infection
Authors: Chistyakova M. V. , Govorin A. V. , Kalinkina T. V. , Medvedeva N. A. , Kudryavtseva Ya. V. 
Published: January 2023

Aim. To study the condition of the right heart and hepatolienal circulation in patients three months after COVID-19.Material and Methods. A total of 87 patients aged on average 36.2 years who were treated for COVID-19 three months before underwent echocardiography and the study of hepatolienal blood flow. Patients were divided into groups: group 1 comprised patients with CT 0; group 2 comprised patients with bilateral pneumonia CT 1–2, and group 3 comprised patients with CT 3–4. Control group comprised 22 patients who did not undergo COVID–19.Results. In patients of group 1, the diastolic velocity of the transtricuspid flow increased by 24% compared to the control p <0.001. The ratio of diastolic velocities E/A and Em/Am decreased in all groups, and the greatest abnormalities were found in group 3. In group 3, systolic pressure in the pulmonary artery increased; the right ventricle, fibrous ring, right branch of the pulmonary artery, and diameters of the inferior vena cava, portal vein, and splenic veins increased. There was a decrease in the flow rate in the splenic vein (14%), and sizes of the liver and spleen increased. Correlations were established between increased pressure in the pulmonary artery and functional parameters of the heart and hepatolienal blood flow as well as between morpho-functional parameters of the heart and indicators of the portal vein, p < 0.001.Conclusion. Three months after the coronavirus infection, patients with mild and moderate severity of the disease developed subclinical abnormalities in the diastolic function of the right ventricle. In patients with severe viral pneumonia, there was also increased pressure in pulmonary artery; the dilatations of the right ventricle, pulmonary artery, splenic vein, and portal veins developed along with a decrease in the flow rate in the splenic vein and increases in the liver and spleen.
Incidence, risk factors, and severity of clinical manifestations of skin vasculitis in patients with HCV- and HCV/HIV-infection
Authors: Dunaeva N. V. , Romanova S. Yu. , Dubina I. A. , Lapin S. V. , Rassokhin V. V. , Gusev D. A. 
Published: January 2023

Introduction. Several viruses including hepatitis C virus (HCV) and human immunodeficiency virus (HIV) can induce vasculitis.Aim. We aimed to study the incidence, risk factors, and severity of skin vasculitis in patients with HCV and HCV/HIV coinfection.Patients and Methods. The study group included 331 patients (254 patients with HCV and 77 patients with HCV/HIV coinfection) referred to a specialized hepatology center for antiviral therapy of HCV infection.Results. Skin vasculitis was found in 21% (95% CI: 17–25%) of cases, n = 69/331. Skin vasculitis was observed in in 20% of patients infected with HCV (95% CI: 15–25%) and in 25% of HIV/HCV co-infected patients (95% CI; 16–35%), χ2 = 0,892, р = 0,345. Most patients with vasculitis infected with HCV had cryoglobulinemia (94%, n = 47/50), meanwhile, in HIV/HCV co-infected patients, cryoglobulinemia was found in 63% cases (n = 12/19), χ2 = 10.568, р = 0.001. Multiple regression analysis showed that skin vasculitis was related with cryoglobulinemia (OR = 6,928, 95% CI: 3.245–14.790, р < 0.001), liver cirrhosis (OR = 2.015, 95% CI: 1.062–3.824, р = 0.032), duration of overt HCV infection (OR = 1.057, 95% CI: 1.021–1.094, р = 0.002), patients age (OR = 1.029, 95% CI: 1.002–1.057, р = 0.033) and inversely related with plasma alanine transaminase (OR 0.433, 95% CI: 0.229–0.820, р = 0.010). The statistical model was normalized for gender, HIV-positivity and bilirubin levels, and regression equation constant was 4.398 (p < 0.001). The intensity of skin rashes was comparable in HCV infected and HCV/HIV co-infected patients (χ2 = 6.741, р = 0.081), and was highly correlated with cryoglobulin levels both in HCV infected (r = 0.788, p < 0.001), and HCV/HIV co-infected patients (r = 0.909, p = 0.001).Conclusion. Skin vasculitis was found in 20–25% of cases among patients with HCV infection and HCV/HIV co-infection. Cryoglobulinemia was the main factor associated with skin vasculitis, and severity of skin lesions was closely related with cryoglobulin levels.
IMPLEMENTASI PROGRAM METODE PEMBIASAAN TADARUS AL-QUR’AN TERHADAP PENINGKATAN KEMAMPUAN MEMBACA AL-QUR’AN SISWA SEKOLAH MENENGAH PERTAMA
Authors: Febriyanti Meliyana , Hindun Hindun , Juliana Rina 
Published: January 2023

ABSTRAK
Tadarus Al-Qur’an atau kegiatan membaca Al-Qur’anmerupakan salah satu bentuk peribadatan yang diyakini dapat mendekatkan diri kepada Allah SWT dapat meningkatkan keimanan dan ketaqwaan yang berimplikasi pada sikap dan perilaku positif, dapat mengontrol diri, dapat tenang, lisan terjaga,dan istiqomah dalam beribadah. Dengan adanya anak terbiasa membaca Al-Qur’an setiap hari, maka itu sebagai langkah awal dalam mengyahati, memahami, mencintai dan mengamalkan apa yang terkandung di dalamnya.Pendekatan Penelitian yang penulis gunakan adalah deskriptif kualitatif. Pengumpulan data dilakukan dengan teknik observasi, wawancara dan dokumentasi. Teknik analisis data dilakukan dengan reduksi data, penyajian data dan penarikan kesimpulan serta verifikasi keterpercayaan hasil penelitian diperoleh dengan teknik triangulasi data. Hasil penelitian peningkatan kemampuan membaca Al-Qur’an melalui program metode pembiasaan tadarus Al-Qur’an dapat dikatakan sebagai program yang sangat baik. Faktor yang menjadi kendala program tadarus Al-Qur’an diantaranya adalah alokasi waktu yang kurang, kurang menghargai waktu, dan factor lingkungan siswa.Sedangkan solusi untuk mengatasi kendala tersebut adalah motivasi dan perhatian dari guru, ciptakan suasana yang inovatif, ciptakan peraturan baru, dan memberikan reward dan funishment.

Kata Kunci: implementasi, metode pembiasaan tadarus Al-Qur’an
KREATIVITAS GURU PENDIDIKAN AGAMA ISLAM DALAM MEMOTIVASI BELAJAR SISWA SEKOLAH MENENGAH PERTAMA
Authors: Saputra Edi , Anwar Kasful , Oktarina Yulia , Istiani Nur 
Published: January 2023

ABSTRAK
Penelitian ini bertujuan untuk mengetahui kreatifikas guru pendidikan agama islam dalam memotivasi pembelajaran siswa di SMP Negeri 22 Merangin. Penelitian ini merupakan penelitian kualitatif yang teknik pengumpulan datanya dengan teknik wawancara, Observasi, dan Dokumentasi. Hasilnya yaitu kreativitas Guru PAI dalam memotivasi belajar siswa seperti penggunaan metode pembelajaran yang bervariasi, penggunan media pembelajaran yang menarik perhatian siswa, melakukan kegiatan pembelajaran di luar jam pembelajaran PAI, Pengelolaan kelas yang baik sesuai metode yang di pakai. Kemudian Motivasi yang di dapatkan siswa ada beeberapa faktor seperti di beri hukuman dan Penghargaan, siswa lebih aktif dalam pembelajaran, anak di dalam kelas di jamin keamanan dan kenyamanannya, dan faktor pendukung guru melakukan kreativitas yaitu guru menggunakan metode yang bervariasi, memiliki sifat humoris dan menghargai pendapat siswanya, dan faktor penghambat Guru melakukan kreativitas ada beberapa seperti fasilitas sekolah,wawasan pengajaran yang kurang, usia, dan Guru merasa puas dengan media yang di pakai.

Kata Kunci: Kreativitas Guru, Pendidikan Agama Islam, Motivasi Belajar.
INTEGRALISASI PENDIDIKAN NILAI-NILAI AGAMA KE DALAM PENDIDIKAN POLITIK MASSIV
Authors: Oktarina Soraya 
Published: January 2023

Pendidikan politik, upaya meningkatkan pemahaman dan pengetahuan masyarakat tentang politik, mendorong ketertarikan individu untuk terjun kedalam aktivitas politik. Dewasa ini, politik kadung dikenal dengan diksi kotor, curang, buruk, dan tidak ramah. Diperlukan suatu pembaharuan iklim dan citra politik yang menyejukan. Agama merupakan landasan dan pijakan individu dalam bersikap. Memasukan nilai nilai ajaran agama islam dalam kegiatan Pendidikan politik, akan menghasilkan suatu budaya politik yang humanistic. Pendidikan politik ditujukan untuk menanamkan pentingnya demokrasi, keterbukaan dan empati, keadilan, persatuan dan sikap saling menghargai. Sementara islam dan Al-quran, adalah pedoman lengkap yang secara subtansial mengatur kehidupan manusia berdasarkan keadilan. Penanaman Nilai agama dalam proses Pendidikan politik menjadi harapan baru guna melahirkan suasana politik damai, bermartabat dan beradab.
KOMPETENSI PEDAGOGIK GURU AKIDAH AKHLAK DI MADRASAH TSANAWIYAH NEGERI 1 MERANGIN
Authors: Baitullah Riski , Indriyani Tuti , Oktarina Yulia 
Published: January 2023

Madrasah Tsanawiyah Negeri 1 Merangin adalah salah satu lembaga pendidikan yang terletak di Jl. Bangko Sei Manau Km.2, Kecamatan Jambi Selatan, Kota Jambi. Tujuan dilakukannya penelitian ini adalah Untuk mengetahui mengembangkan karakteristik perserta didik yang meliputi : Etnit, Kulturan, Status Sosial, Minat ingin Untuk mengetahui bagaimanakah merancang pembelajaran akidah akhlak.Jenis penelitian yang dilakukan adalah penelitian lapangan yaitu penelitian yang pengumpulan datanya dilakukan dengan cara memperoleh data melalui penelitian berdasarkan objek lapangan. Adapun metode pengumpulan data yang digunakan adalah metode observasi, wawancara, dan dokumentasi.Teknik analisis data yang digunakan ialah analisis triangulasi. Hasil penelitian menjelaskan Untuk mengetahui bagaimanakah merancang pembelajaran akidah akhlak ialah dengan cara yang dilakukan menggunakan antara lain metode ceramah, Diskusi dan Dokumentasi. Adapun masalah yang dihadapi guru akidah akhlak saat dalam proses pembelajaran terdapat siswa siswi tidak semangat dan malas malasan saat belajar. Solusi nya dengan cara mengatasi dengan memberikan dukungaan dan motivasi semangat dalam belajar dan memperhatikan saat guru menjelaskan di depan kelas.
Fostering literacy: Pre-primary pre-service teachers’ reading habits and literature knowledge
Authors: Tabuenca-Cuevas Maria , Fernández Molina Javier 
Published: January 2023

In pre-primary education, there is a need for specific research into developing awareness of literary genres that can be used in the EFL classes to promote literacy. A total of 264 students on the Teaching English for Pre-primary Education course participated on an online questionnaire adapted from Cremin et al. (2008), using both qualitative and quantitative questions to provide an insight into the issue. The first part of the questionnaire examined the reading habits of pre-service teachers. The second part probed into the specific knowledge of texts and authors in general for use in the EFL pre-primary classroom. The results showed that there is a very limited tradition of reading outside the EFL classroom from students’ experiences, that there is a very narrow catalogue of texts and genres that students are familiar with and lastly, that literature is primarily seen as a vehicle for vocabulary acquisition. Thus, it is essential to encourage future EFL teachers not only to become more knowledgeable about genres, but also aware of the different reasons to use literature in the classroom to promote literacy.
PREDICTED MAX HEART RATE SHOULD NOT BE USED FOR PATIENTS IN CARDIAC REHABILITATION
Authors: Steenson Katherina , Keteyian Steven J. , Grimshaw Crystal , Mandel Noah , Brawner Clinton A. 
Published: January 2023

https://youtu.be/o3sLspfpDqs

BACKGROUND
A maximal exercise test is often not available for patients in cardiac rehabilitation (CR) and many programs determine a target heart rate (THR) using equations to estimate maximum heart rate (HRmax). The purpose of this study was to describe the % of patients in which a THR based on an estimated HRmax would result in a heart rate (HR) that is consistent with guidelines (i.e., 50%–80% HR reserve) in patients with heart disease (HD) on beta-blockade therapy.

METHODS
This was a secondary analysis of the iATTEND study; a randomized trial of facility-based only CR vs. hybrid CR. Subjects included in the present analysis had a history of myocardial infarction, coronary revascularization procedure, or heart failure; beta-blockade therapy; and sinus rhythm. Exclusion criteria were heart transplant, atrial fibrillation, implanted pacemaker, and exercise-induced ischemia. Measured HR reserve (maximum - rest) was determined from a symptom-limited maximal exercise test with gas exchange performed on a treadmill. Estimated HRmax was determined using (a) 220 age and (b) a published equation based on patients with HD with beta-blockade (HD BB; 164-0.72xage). % measured HR reserve associated with 60% and 85% estimated HRmax using each equation was compared to guideline recommended intensity of 50%–80% measured HR reserve. Paired sample t-tests were used to compare measured HRmax to the 2 estimates of HRmax.

RESULTS
Among 166 subjects (68% male; age= 59±11 yr [mean±SD]) measured HRmax was 133±21 min 1. Compared to measured, estimated HRmax using 220-age was significantly higher (161±11 min- 1; p&lt;.001) and estimated HRmax using HD-BB was significantly lower (121±8 min-1; p&lt;.001). At 60% of 220-age, 19% of subjects would have been provided a THR that was consistent with guidelines; 72% would have been too low. At 60% of HD-BB, 1% of subjects would have been provided a THR that was consistent with guidelines; 99% would have been too low. At 85% of 220-age, 16% of subjects would have been provided a THR that was consistent with guidelines; 84% would have been too high. At 85% of HD-BB, 36% of subjects would have been provided a THR that was consistent with guidelines; 15% would have been too high.

CONCLUSION
THR based on % estimated HRmax from 220-age and HD-BB do not provide an exercise training HR target that is consistent with guideline recommendations, thus should not be used to prescribe an exercise intensity in patients with HD on BB therapy.