bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimension‐independent Markov chain Monte Carlo on the sphere
Authors: Lie Han Cheng , Rudolf Daniel , Sprungk Björn , Sullivan T. J. 
Published: April 2023

AbstractWe consider Bayesian analysis on high‐dimensional spheres with angular central Gaussian priors. These priors model antipodally symmetric directional data, are easily defined in Hilbert spaces and occur, for instance, in Bayesian density estimation and binary level set inversion. In this paper we derive efficient Markov chain Monte Carlo methods for approximate sampling of posteriors with respect to these priors. Our approaches rely on lifting the sampling problem to the ambient Hilbert space and exploit existing dimension‐independent samplers in linear spaces. By a push‐forward Markov kernel construction we then obtain Markov chains on the sphere which inherit reversibility and spectral gap properties from samplers in linear spaces. Moreover, our proposed algorithms show dimension‐independent efficiency in numerical experiments.
Investigating small molecule compounds targeting psoriasis based on cMAP database and molecular dynamics simulation
Authors: Zhou Fang , Yao Huiping , Ma Zhen , Hu Xinhong 
Published: April 2023

AbstractObjectivePsoriasis (PSO) is a chronic inflammatory skin disease that severely affects the physical and mental health of patients. Drug resistance has been developed upon current drug treatments, and there is no specific therapy. The aim of this study was to screen promising novel drug candidates for PSO using molecular dynamics (MD) simulations.MethodsThe data of PSO were downloaded from gene expression omnibus (GEO) database and subjected to variance analysis. Target proteins and small molecule compounds targeting PSO were predicted in the connective map (cMAP) database. Molecular docking, MD simulation, and trajectory analysis were conducted to predict the binding of target proteins to compounds.Results1999 differentially expressed genes in PSO were obtained by differential analysis. Through cMAP database prediction, a low Score value of −45.69 for lymphocyte cell‐specific protein‐tyrosine kinase (LCK) was revealed, and aminogenistein was identified as the compound targeting LCK, and LCK was notably highly expressed in the PSO samples. The drugScore of the binding pocket P_0 was 0.814656, which was docked with aminogenistein. The results showed that there were more than one binding site between LCK and aminogenistein with binding energy less than −7.0 kJ/mol, and the docking was relatively stable. The results of root‐mean‐square deviation (RMSD), root‐mean‐square fluctuation (RMSF), Gyrate, number of hydrogen bonds and total free binding energy in MD simulations showed that the binding of aminogenistein to LCK was relatively solid.ConclusionAminogenistein has good protein‐ligand interaction and stability with LCK, a target of PSO, and is a novel drug candidate for PSO.
Public attitudes toward organized labor
Authors: Macdonald David 
Published: April 2023

AbstractObjectiveDespite declining and historically low membership, labor unions remain important and relevant actors in American politics. Accordingly, we have learned a good deal about the economic and political consequences of labor unions and union membership. However, we know less about the dynamics, determinants, and political consequences of public attitudes toward organized labor.MethodsI use a variety of survey data to (1) track public support for labor unions over time, (2) to examine the microlevel determinants of labor attitudes, and (3) to examine how such attitudes shape voting behavior in national elections.ResultsFirst, I show that American public opinion has consistently been “pro‐labor” and that such sentiment is growing in recent years, despite historically low levels of union membership. Second, I show that while the strongest individual‐level correlate of union support is labor union affiliation, pluralities, and in some cases majorities, of nonunion‐affiliated Americans hold “pro‐labor” attitudes as well. Finally, I show that labor union attitudes significantly predict (among both union and nonunion‐affiliated Americans) support for the Democratic presidential candidate, net of partisanship, ideology, core political values, and macroeconomic conditions.ConclusionOverall, these results show that low levels of union membership do not imply an “anti‐union” mass public. These findings also demonstrate that attitudes toward labor unions are politically consequential.
Nondegeneracy of solutions to the critical p$p$‐Laplace Kirchhoff equation
Authors: Deng Shengbing , Tian Xingliang 
Published: April 2023

AbstractWe establish the nondegeneracy of solutions in suitable space to the following ‐Laplace Kirchhoff equation with critical Sobolev exponent:
where , , and is the critical Sobolev exponent. In particular, we prove that uniqueness breaks down for high dimension , that is, we show that there exist two nondegenerate solutions that seem to be completely different from the result of critical ‐Laplace equation () or the low‐dimensional Kirchhoff equation (the case ).
Aerobic exercise training‐induced alteration of gut microbiota composition affects endurance capacity
Authors: Uchida Masataka , Fujie Shumpei , Yano Hiromi , Iemitsu Motoyuki 
Published: April 2023

AbstractThis study aimed to clarify whether aerobic exercise training‐induced alterations in the gut microbiota affect physiological adaptation with endurance exercise capacity. In study 1, ICR mice were randomly divided into three groups: vehicle intake + sedentary (V+S), vehicle intake + exercise training (V+Ex) and antibiotic intake + exercise training (AB+Ex). In the exercise training groups, treadmill running was performed for 8 weeks. During the exercise training intervention, the antibiotic‐intake group freely drank water containing antibiotics. In study 2, ICR mice were randomly divided into three groups: Sham, transplantation of caecum microbiota from sedentary mice (Sed‐CMT) and exercise training mice (Ex‐CMT). In study 1, the treadmill running time to exhaustion, an index of maximal aerobic capacity, after aerobic exercise training in the V+Ex group was significantly longer than that in the V+S and AB+Ex groups. Gastrocnemius muscle citrate synthase (CS) activity and PGC‐1α protein levels in the V+Ex group were significantly higher than in the V+S and AB+Ex groups. The bacterial Erysipelotrichaceae and Alcaligenaceae families were positively correlated with treadmill running time to exhaustion. In study 2, the treadmill running time to exhaustion after transplantation was significantly higher in the Ex‐CMT group than in the Sham and Sed‐CMT groups. Furthermore, CS activity and PGC‐1α protein levels in the gastrocnemius muscle were significantly higher in the Ex‐CMT group than in the Sham and Sed‐CMT groups. Thus, gut microbiota altered by aerobic exercise training may be involved in the augmentation of endurance capacity and muscle mitochondrial energy metabolism.
imageKey points
Aerobic exercise training changes gut microbiota composition, and the Erysipelotrichaceae and Alcaligenaceae families were among the altered gut bacteria.
The gut microbiota was associated with endurance performance and metabolic regulator levels in skeletal muscle after aerobic exercise training.
Continuous antibiotic treatment attenuated the increase in endurance performance, citrate synthase activity and PGC‐1α levels in skeletal muscle induced by aerobic exercise training.
Gut microbiota transplantation from exercise‐trained mice improved endurance performance and metabolic regulator levels in recipient skeletal muscle, despite the absence of aerobic exercise training.
Rapidly rotating neutron stars in $$f(R,T)=R+2 \lambda T$$ gravity
Authors: da Silva F. M. , Santos L. C. N. , Mota C. E. , da Costa T. O. F. , Fabris J. C. 
Published: April 2023

AbstractIn this work, we study the influence of f(R, T) gravity on rapidly rotating neutron stars. First we discuss the main aspects of this modified theory of gravity where the gravitational Lagrangian is an arbitrary function of the Ricci scalar R and of the trace of the energy–momentum tensor T. Then we present the basic equations for neutron stars including the equations of state used in the present work to describe the hadronic matter. Some physical quantities of interest are calculated such as mass–radius relations, moments of inertia, angular momentum, and compactness. By considering four different rotation regimes, we obtain results that indicate substantial modifications in the physical properties of neutron stars in f(R, T) gravity when compared to those in the context of general relativity. In particular, the mass–radius relation for sequences of stars indicates that f(R, T) gravity increases the mass and the equatorial radius of the neutron stars for stars rotating with an angular velocity smaller than Kepler limit.
Human behavioral crowds review, critical analysis and research perspectives
Authors: Bellomo Nicola , Liao Jie , Quaini Annalisa , Russo Lucia , Siettos Constantinos 
Published: April 2023

This paper presents a survey and critical analysis of the mathematical literature on modeling and simulation of human crowds taking into account behavioral dynamics. The main focus is on research papers published after the review [N. Bellomo and C. Dogbè, On the modeling of traffic and crowds: A survey of models, speculations, and perspectives, SIAM Rev. 53 (2011) 409–463], thus providing important research perspectives related to new, emerging trends. The presentation addresses the scaling problem corresponding to microscopic (individual-based), mesoscopic (kinetic), and macroscopic (hydrodynamic) modeling and analysis. A multiscale vision guides the overall content of the paper. The critical analysis of the overall content naturally leads to research perspectives. A selection of them is brought to the attention of the interested reader together with hints on how to deal with them.
On the generalized virtual Goeritz matrix for virtual knots
Authors: Lee Kyeonghui , Kim Sera 
Published: April 2023

Im et al. [Signature, nullity and determinant of checkerboard colorable virtual links, J. Knot Theory Ramifications 19(8) (2010) 1093–1114] introduced how to define Goeritz matrices for checkerboard colorable virtual links. In this paper, we extend this for the Goeritz matrices of virtual knots. And we consider its signature and determinant and show they are invariants for virtual knots.
A TRUSTED COMPUTING RESOURCES OPTIMAL SCHEDULING ALGORITHM IN INDUSTRIAL INTERNET AND HEALTHCARE INTEGRATING DRL, BLOCKCHAIN AND END-EDGE-CLOUD
Authors: LIU ZONGMEI , LI JIANXIN 
Published: April 2023

With the rapid development of the Internet of Things (IoT) and Internet technology, the product of the combination of the two, the Industrial Internet, has also received extensive attention and there are more and more research achievements related to the Industrial Internet. In the industrial Internet system, the communication network system composed of sensors, communication nodes, controllers and other intelligent devices can realize efficient and convenient data interaction between people and machines, providing an important infrastructure and technical support for industrial big data analysis and intelligent production. However, in the current industrial Internet system, industrial equipment users generally have the problem of low computing energy efficiency, and the collected industrial data has a high-security risk in the transmission, processing and other processes. At the same time, the size and scale of the industrial Internet equipment group is huge, and the lack of rational resource allocation leads to excessive waste of computing resources in the system, which is also a prominent problem of the current industrial Internet system. In response to the above questions, this paper, on the basis of reading a large number of documents, integrates the improved DRL algorithm, End-Edge-Cloud architecture and blockchain to form a new industrial Internet architecture. The architecture realizes computing offload through the three-tier structure of terminal layer, edge layer and cloud layer, and guarantees the security of industrial data through the decentralized feature of blockchain, ultimately achieving the goal of reducing energy consumption, computing overhead and trusted computing. In the architecture proposed in this paper, the dynamic unloading of industrial data and computing tasks is achieved through a three-tier architecture. The MDP is used to build an optimization problem model, and the improved DRL algorithm is used to iteratively solve the optimal computing resource scheduling strategy. The main research contents of this paper include (1) Using MDP to model optimization problems; (2) Propose an industrial Internet system architecture that integrates and improves DRL, “end edge cloud” and blockchain; (3) The MDP problem is solved iteratively based on deep reinforcement learning. The simulation results show that the proposed architecture has more advantages than the existing six architectures in terms of computing cost, equipment energy consumption and total working time.
Intelligent engineering management modeling for computer technology and data mining
Authors: Feng Ning , Shabaz Mohammad , Elashiri Mohamed A. , Arias-Gonzáles José Luis , Chaudhury Sushovan , Al-Masoudy Miami Abdul Aziz , Oyebode Oluwadare Joshua 
Published: April 2023

The author suggests using computer technology and data mining in intelligent engineering management to increase the management capacity of engineering projects and decrease the consumption of construction expenses. The emphasis is mostly on theoretical and analytical approaches to problems of practical concern for data mining, perhaps in combination with other conventional tools, and the associated applications to engineers and managers of various industrial sectors. This has immediate benefits for both academic and applied data mining researchers as well as research students. The author developed a BIM project management system based on Browser/Server architecture and Client/Server architecture in conjunction with BIM technology and the BIM 4D model. To execute complete project management of business management, real-time control, and decision support, the system must establish and use its business logic and data exchange link. Each module in the 4D construction dynamic management subsystem recognizes dynamic management of the construction process, and the working duration of each module is determined by calculating by using the unified engineering decomposition principle, rationalizing the relevant data through time parameters, recording the acquired management data and storing it in the BIM database, and connecting the BIM database bi-directionally through the web server through the system integration. The results showed that when the time is 20[Formula: see text]min, the throughput of the system is higher than [Formula: see text][Formula: see text]kb/s. The system can effectively improve the project management ability, reduce the construction cost and construction period of the project, and the system responds quickly.
Cone Beam CT Assessment of Bone Width of Upper and Lower Jaws for Dental Implant Placement: An Iraqi Study
Authors: Khazaal Al-Jaboori Aseel S. , Hassan Nuhad A. 
Published: April 2023

Background. Implantology focuses on the measurement of bone thickness in both the lower and upper jaws. This study aimed to measure and compare alveolar bone thickness of the upper and lower jaws at single edentate sites and cortical bone thickness of their mesial and distal dentate sites. Methods. Thickness of alveolar bone thickness was measured in 80 upper and 80 lower implant edentate sites and that of buccal and lingual cortical plates of their mesial and distal dentate sites using Cone beam CT. The bone thickness of the edentulous sites was recorded at 3 points (crestal bone, five mm from the crest, and ten mm from the crest), while the bone thickness of the dentate sites was determined at four points (crestal bone, midroot bone, mid of the alveolar bone housing, and apical portion). Results. An increased amount of bone was measured from the crest to the apical portion of the dentate sites on the buccal and lingual sides of both jaws with a highly significant difference detected among all the tested points (

P
<

0.0001

). No statistical difference was detected between the means of buccal bone width at the first 3 points, except at point 4 (the apical portion), where the mean of the lower jaw (3.35 ± 0.54) was significantly larger than that of the upper jaw (3.17 ± 0.55) (

P
=
0.04

). Bone width measured in the edentulous sites showed a gradual increase from the crest to the apical portions in both jaws. Conclusion. Bone thickness at the coronal levels is low and susceptible to resorption compared to the apical portions regardless of the dentate state.
Abstract LB090: IL-18 secreting chimeric antigen receptor T cells targeting glypican-3show superior persistence and antitumor immunity against hepatocellular carcinoma
Authors: Jeong Joseph H. , Chang Young-Kyun , Kang You-Yeon , Lee Jeong-Yun , Lee Sae-Rom , Lee Yun-Kyung , Kim Young-Ho , Kwon Byoung S. 
Published: April 2023

Abstract
Over the last decade, immunotherapy has revolutionized the way we treat cancer primarily by boosting the body’s own immune system to help fight cancer. In particular, an engineered T cell therapy, namely chimeric antigen receptor (CAR) T cell therapy, is a more aggressive way to modify T cells to recognize cancer cells and destroy them. Although these CAR-T therapies have shown remarkable clinical responses in patients with hematological malignancies, their efficacy in solid tumor treatment has been disappointing due to many challenges: lack of tumor-specific antigen targets, loss of the CAR T-cell persistence, the inability of CAR-T cells to effectively infiltrate into solid tumors, toxicities of cytokine release syndrome and neurologic toxicity, and the immunosuppressive tumor microenvironment (TME). In this regard, we report here that we have successfully developed a CAR-T cell therapy, referred to as EU307, to treat one type of solid tumor, hepatocellular carcinoma (HCC). EU307 is a fourth-generation CAR-T therapy that targets the HCC-specific tumor antigen of glypican-3 (GPC3), and also secretes IL-18 which results in autocrine co-stimulation of CAR-T cells and reprogramming of the TME into a tumor-killing environment. Through a sophistically optimized manufacturing process in our good manufacturing practices (GMP) facility, we are able to manufacture CAR-T cells with stem cell memory (TSCM) and central memory (TCM) phenotypes. Functionally, EU307, when infused with as little as 0.1 × 106 total cells per animal, showed superior in vivo persistence and antitumor immunity in an HCC tumor-bearing mouse model. Furthermore, a single dose toxicity study in the same disease mouse model determined the no observed adverse effect level (NOAEL) as 5.0 × 105 total cells per male and 1.0 × 106 total cells per female. Taken together, our studies demonstrate that we have a developed a novel fourth-generation CAR-T therapy to treat HCC, a solid tumor that expresses a high-level of tumor-specific GPC3, by overcoming previously limiting factors in the development of CAR-T therapies against solid tumors.
Citation Format: Joseph H. Jeong, Young-Kyun Chang, You-Yeon Kang, Jeong-Yun Lee, Sae-Rom Lee, Yun-Kyung Lee, Young-Ho Kim, Byoung S. Kwon. IL-18 secreting chimeric antigen receptor T cells targeting glypican-3show superior persistence and antitumor immunity against hepatocellular carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr LB090.
Abstract LB096: IL15-engineered tumor infiltrating lymphocytes (cytoTIL15TM) exhibit activity against autologous tumor cells from multiple solid tumor indications without IL2
Authors: Pedro Kyle D. , Burga Rachel , Ocando Alonso Villasmil , Langley Meghan , Kulkarni Gauri , Ao Zheng , Primack Benjamin , Ross Theresa , Young Violet , Tchaicha Jeremy , Ols Michelle , Meulen Jan Ter 
Published: April 2023

Abstract
Tumor infiltrating lymphocyte (TIL) therapy has shown promising results in the treatment of metastatic melanoma. However, TIL therapy has conventionally required co-administration of IL2, which is associated with toxicity in patients. We previously showed that melanoma TILs engineered to express membrane-bound IL15 (mbIL15) under the control of the ligand acetazolamide (ACZ) can achieve IL2-independent expansion during manufacturing, antigen-independent persistence in vitro and anti-tumor efficacy in vivo. In the current study, we extend the cytoTIL15 cell therapy product concept to indications beyond melanoma including non-small cell lung cancers (NSCLC), triple-negative breast cancers (TNBC) and head and neck squamous cell carcinomas (HNSCC), tumor types which represent significant unmet medical needs, particularly in the post-checkpoint inhibitor refractory setting. TILs from primary NSCLC, HNSCC and TNBC were engineered to express mbIL15 in the presence of ACZ and expanded in the absence of IL2 using our proprietary rapid expansion protocol (REP). CytoTIL15 cells were predominantly CD8 positive, enriched for mbIL15 expression and maintained T cell receptor variable beta chain (TCRVβ) diversity throughout expansion. In vitro antigen- and cytokine-independent survival and polyfunctionality of cytoTIL15 cells was measured from cultures that included ACZ. To assess anti-tumor activity, cytoTIL15 cells were co-cultured with autologous patient-derived cell lines (PDc) or tumor digests from patient-derived xenografts (PDx), and cytotoxicity and IFNγ release into supernatant was measured. In vitro, cytoTIL15 cells + ACZ exhibited similar or increased polyfunctionality compared to unengineered TIL + IL2. Unlike unengineered TILs, cytoTIL15 cells + ACZ persisted in an antigen-free setting without IL2, were cytotoxic to autologous PDc and released IFNγ in response to autologous PDx tumor digest. Taken together, these data show that IL2-independent, fully functional cytoTIL15 cells can successfully be generated from tumors such as NSCLC, HNSCC & TNBC, which afflict large numbers of patients.
Citation Format: Kyle D. Pedro, Rachel Burga, Alonso Villasmil Ocando, Meghan Langley, Gauri Kulkarni, Zheng Ao, Benjamin Primack, Theresa Ross, Violet Young, Jeremy Tchaicha, Michelle Ols, Jan Ter Meulen. IL15-engineered tumor infiltrating lymphocytes (cytoTIL15TM) exhibit activity against autologous tumor cells from multiple solid tumor indications without IL2 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr LB096.