bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graph theoretical description of phase transitions in supramolecular assemblies of surfactants
Authors: Yang Ruochen , Bernardino Kalil , Xiao Xiongye , Gomes Weverson R. , Mattoso Davi A. , Kotov Nicholas A. , Bogdan Paul , de Moura André F. 
Published: March 2023

Abstract
Phase transitions are typically quantified using order parameters, such as crystal lattice distances and radial distribution functions, which can identify subtle changes in crystalline materials or high-contrast phases with large structural differences. However, the structural changes are more difficult to quantify for phases with high asymmetry and multiscale organization as well as for the structural fluctuations preceding phase transitions, which are essential for understanding the system pathways between phases. Here, we show that graph theoretical (GT) descriptors can successfully characterize different phases of a water/surfactant system and pathways between them for hierarchically organized phases. GT centrality parameters and node-based fractal dimension can identify complex phases more accurately than traditional analyses and quantify the system behavior preceding the transitions, capturing fluctuation-induced breakup of aggregates and their long-range cooperative interactions. GT parametrization can be generalized for a wide range of chemical systems, facilitatingidentification of complex supramolecular phases and engineering nanostructures at multiple scales.
Parametric Optimization on HPC Clusters with Geneva
Authors: Weßner Jonas , Berlich Rüdiger , Schwarz Kilian , Lutz Matthias F. M. 
Published: March 2023

Abstract
Many challenges of today's science are parametric optimization problems that are extremely complex and computationally intensive to calculate. At the same time, the hardware for high-performance computing is becoming increasingly powerful. Geneva is a framework for parallel optimization of large-scale problems with highly nonlinear quality surfaces in grid and cloud environments. To harness the immense computing power of high-performance computing clusters, we have developed a new networking component for Geneva, the so-called MPI Consumer, which makes Geneva suitable for HPC. Geneva is most prominent for its evolutionary algorithm, which requires repeatedly evaluating a user-defined cost function. The MPI Consumer parallelizes the computation of the candidate solutions' cost functions by sending them to remote cluster nodes. By using an advanced multithreading mechanism on the master node and by using asynchronous requests on the worker nodes, the MPI Consumer is highly scalable. Additionally, it provides fault tolerance, which is usually not the case for MPI programs but becomes increasingly important for HPC. Moreover, the MPI Consumer provides a framework for the intuitive implementation of fine-grained parallelization of the cost function. Since the MPI Consumer conforms to the standard paradigm of HPC programs, it vastly improves Geneva's user-friendliness on HPC clusters. This article gives insight into Geneva's general system architecture and the system design of the MPI Consumer as well as the underlying concepts. Geneva, including the novel MPI Consumer, is publicly available as an open source project on GitHub and is currently used for fundamental physics research at GSI in Darmstadt, Germany.
Feasibility study of an automated Strabismus Screening Test using Augmented Reality and Eye-tracking (STARE)
Authors: Nixon Nisha , Thomas Peter , Jones Pete 
Published: March 2023

Abstract
Background
New digital technologies (augmented reality headsets, eye-tracking) may potentially allow for automated assessments of ocular misalignment. Here, we evaluate the feasibility of a novel, open-source strabismus test (“STARE”) as an automated screening tool.
Methods
Work progressed in 2 phases. In phase 1 (“development”), we used Fresnel prisms to elicit horizontal misalignments of known magnitude (1–40 prism dioptres) in orthotropic controls. In phase 2 (“validation”), we applied the system to adults with an established diagnosis of strabismus, and quantified the ability of the test to distinguish between those with horizontal misalignment and those without. Agreement between the alternate prism cover test measurements and STARE measurements was computed using Bland-Altman plots and product-moment correlation coefficients.
Results
Seven orthotropic controls and nineteen patients with strabismus were recruited (mean age 58.7 ± 22.4 years). STARE was able to identify the presence of horizontal strabismus with an area under the curve of 1.00 (100% sensitivity and 100% specificity). The mean difference (bias) {95%CI} was 2.1 {-1.8, 9.9} prism dioptres, and the 95% coefficient of repeatability {95%CI} was ± 27.9 {14.8, 50.8} prism dioptres. The Pearson correlation between APCT and STARE was r24 = 0.62, P < 0.001.
Conclusions
STARE shows promise as a simple, automated tool for performing a screening assessment of strabismus. It is a rapid (60 second) test that can be performed using a consumer augmented reality headset with integrated eye-tracking, and might conceivably be used remotely by non-specialists in future as a means of highlighting individuals needing face-to-face specialist care.
Content validation of a Mental Wellness Measuring instrument for Adolescents Living with HIV: A modified Delphi Study
Authors: Orth Zaida , Wyk Brian van 
Published: March 2023

Abstract
A growing body of evidence suggests that improving the mental wellness of adolescents living with HIV (ALHIV) will also result in improved adherence to antiretroviral therapy (ART), as well as improving their general health and wellbeing as they age into adulthood. However, to develop effective strategies and interventions aimed at improving mental wellness, we require age and culturally appropriate instruments to build an evidence base. Currently, there is a lack of mental wellness measures developed for ALHIV, especially in the African context. To address this gap, we developed a measure of mental wellness following modified guidelines set out by DeVellis [1] and Godfred et al. as a guiding framework [2]; (1) Identifying the gap, (2) Set the theoretical foundations and identify domains and (3); Instrument development and initial validation. For the first two steps, we conducted a systematic review, photovoice study and integrative review – which we briefly describe as the findings have been published. Following this we describe the processes to develop the instrument and to establish content validity through a modified Delphi Study. Through this process we were able to refine the instrument which will be subject to further testing. Implications and Contribution: This study aims to add to the body of knowledge on promoting mental health (mental wellness) among adolescents living with HIV in South Africa through developing an appropriate and valid measure of mental wellness for this population. This study reports on the results of a Delphi Study aimed at improving the content validity of the instrument Mental Wellness Measure for Adolescents Living with HIV (MWM-ALHIV).
A Case of Chronic Total Occlusion in Popliteal Artery Recanalized by Double Snare Piercing Technique
Authors: Miyashita Hirokazu , Tobita Kazuki , Uchida Syuhei , Koyama Eiji , Tamaki Yusuke , Yamashita Takayoshi , Saito Shigeru 
Published: March 2023

Abstract
Background:
Although majority of cases with chronic total occlusion (CTO) in femoro-popliteal lesion were treated with antegrade approach only, some lesions require alternative approach due to its complexity. Bi-directional approach is useful on endovascular therapy (EVT) for CTO; however guidewire recanalization is impossible in some challenging cases. The present case shows a successful re-entry technique utilizing two snare catheters from an antegrade and retrograde access site (double snare piecing technique).
Case presentation:
A 79-year-old woman with right leg intermittent claudication (Rutherford category Ⅲ), who had undergone unsuccessful EVT for popliteal CTO, required another EVT for the worsening symptom. Following the failed conventional crossing technique, two snare catheters were placed and the snare loops were pierced by a puncture needle from the skin surface. After an 0.014 wire was inserted into the needle, the needle was withdrawn. The wire was pulled from the retrograde side and was externalized. Then, the antegrade snare catheter was pulled and externalized, to make the wire across the lesion. After that, a microcatheter was advanced along the externalized wire from the retrograde side and cross the lesion. The wire was replaced with a new wire, which completely created pull-through system. After the hemostasis by balloon inflation and lesion preparation, this procedure finished with an endoluminal-covered stent and two inter-woven stents. The re-entry site was covered by the inter-woven stent. She improved her symptom after the procedure, and the lesion has not developed restenosis at 2-years follow-up.
Conclusions:
This re-entry technique of puncturing two snares (double snare piercing technique) might be effective for challenging femoropopliteal CTO cases.
Vacuum Expansion and Collapse Inside an Infinite Shell
Authors: Laforet Christopher 
Published: March 2023

Abstract
The FRW model of cosmology assumes a Universe with uniform pressure and density everywhere in space at a given time. But at the largest scales, the Universe has a web-like structure surrounding large voids, violating these assumptions. Furthermore, a given region of spacetime is describable only by a single metric and therefore it cannot be that the Universe is modelled as an FRW perfect fluid since this would be the incorrect description of both the web and the voids. The cosmic web must be described by metrics with non-zero energy-momentum tensors with non-uniform pressure and density describing the matter within it. Therefore, the model of cosmology describing the expansion of the Universe must be a vacuum solution describing the empty spaces in the Universe surrounded by an infinite, massive shell (the surrounding Universe). Taking the expanding balloon analogy of the expansion of the Universe, the matter-dense portions of the Universe would be like knots in the balloon which stay knotted while the vacuum between them expands. The internal Schwarzschild metric is the model for these vacua. The source of the Schwarzschild metric is shown to be at the event horizon, a location/time of infinite density, not at the singularity, as it is currently assumed. The spatial homogeneity of the metric is demonstrated by visualizing the geometry in the extrinsic Kruskal-Szekeres coordinates (visualized in 1+2 dimensions) as well as examining the Killing vectors for the internal spacetime. Using the coordinate age of the Universe and transition redshift, this predicts the accelerated expansion, the Hubble diagram fits currently available cosmological data, and it gives a Hubble constant H0 of 71.6km/s/M pc. The angular term of the metric describes the relativistic kinematic precession effect known as Thomas Precession which can be interpreted as spin about the time dimension.
Analysis of neoadjuvant chemotherapy for breast cancer: A 20-year retrospective analysis of patients of a single institution
Authors: Chen Danzhi , Wang Qinchuan , Dong Minjun , Chen Fei , Huang Aihua , Chen Cong , Lu Yi , Zhao Wenhe , Wang Linbo 
Published: March 2023

Abstract
Background
Neoadjuvant chemotherapy has been widely applied in operable breast cancer patients. This study aim to identify the predictive factors of overall survival(OS) and recurrence free survival (RFS) in breast cancer patients who received NAC from a single Chinese institution .
Patients and Methods
There were 646 patients recruited in this study. All the patients were treated at department of Surgical Oncology, Sir Run Run Shaw Hospital between February 25, 1999 and August 22, 2018. The relevant clinicopathological and follow-up data were collected retrospectively. RFS and OS were assessed using the Kaplan-Meier method. Multivariate Cox proportional hazards model was also employed.Multi-variate logistic regression model was simulated to predict pathologic complete response (pCR) .
Results
In total, 126 patients (19.5%) achieved pCR during NAC. The 5-year OS was 92.6% and 75.3% in patients with and without pCR, respectively (P<0.001). The 5-year RFS was 93.4% and 71.2%, respectively (P<0.001). No difference was detected among molecular subtypes of 5-year RFS in patients obtained pCR. Factors independently predicting RFS were HER2-positive subtype (hazard ratio(HR), 1.793; P=0.006), triple-negative breast cancer (TNBC) (HR,1.895; P=0.002), Ki-67>25 (HR, 2.363; P=0.044), lymph node involvement after NAC(HR,3.639; P<0.001), pCR (HR, 0.375;P=0.004), and clinical stage III (HR,2.918; P=0.014). Multi-variate logistic regression model was simulated to predict the pCR rate after NAC, according to clinical stage, molecular subtype, ki-67, LVSI, treatment period and histology. In the ROC curve analysis, the AUC of the nomogram was 0.734(95%CI,0.867–12.867).
Conclusions
Following NAC, we found that pCR positively correlated with prognosis and the molecular subtype was a prognostic factor.
Prevalence and determinants of decision regret in long-term prostate cancer survivors following radical prostatectomy
Authors: Lunger Lukas , Meissner Valentin H. , Kopp Benedikt C. G. , Dinkel Andreas , Schiele Stefan , Ankerst Donna P. , Gschwend Jürgen E. , Herkommer Kathleen 
Published: March 2023

Abstract
Background
Patients with localized prostate cancer (PC) are faced with a wide spectrum of therapeutic options at initial diagnosis. Following radical prostatectomy (RP), PC patients may experience regret regarding their initial choice of treatment, especially when oncological and functional outcomes are poor. Impacts of psychosocial factors on decision regret, especially after long-term follow-up, are not well understood. This study aimed to investigate the prevalence and determinants of decision regret in long-term PC survivors following RP.
Methods
3408 PC survivors (mean age 78.8 years, SD = 6.5) from the multicenter German Familial PC Database returned questionnaires after an average of 16.5 (SD = 3.8) years following RP. The outcome of decision regret concerning the initial choice of RP was assessed with one item from the Decision Regret Scale. Health-related quality of life (HRQoL), PC-anxiety, PSA-anxiety, as well as anxiety and depressive symptoms were considered for independent association with decision regret via multivariable logistic regression.
Results
10.9% (373/3408) of PC survivors reported decision regret. Organ-confined disease at RP (OR 1.39, 95%CI 1.02–1.91), biochemical recurrence (OR 1.34, 1.00-1.80), low HRQoL (OR 1.69,1.28–2.24), clinically relevant depressive symptoms (OR 2.32, 1.52–3.53), and prevalent PSA anxiety (OR 1.88,1.17–3.01) were significantly associated with increased risk of decision regret. Shared decision-making reduced the odds of decision regret by 40% (OR 0.59, 0.41–0.86).
Conclusions
PC survivors may experience decision regret even after 16 years following RP. Promoting shared decision-making in light of both established and novel, potentially less invasive treatments at initial diagnosis may help mitigate long-term regret. Awareness regarding patients showing depressive symptoms or PSA anxiety should be encouraged to identify patients at risk of decision regret in need of additional psychological support.
Prevention of Malaria in Pregnancy Through Health Education Intervention Programs on Insecticide-Treated Nets: A Systematic Review
Authors: Opara Monica Onyinyechi , Ismail Suriani , Nashriq Ahmad Iqmer 
Published: March 2023

Abstract
Malaria is a widespread and persistent disease that affects human population globally, particularly in tropical countries. Malaria is a major health issue in sub-Saharan Africa and it contributes to morbidity and mortality among individuals in Africa. Pregnant women have been also reported as high risk of people been infected with malaria. This review attempted to evaluate the various methods used for health education programs and the effectiveness of the programs in improving ITNs, LLINS utilizationamong pregnant women. Methods: The search involved various databases; EBCOHOST, MEDLINE, CINAHL, Cochrane library, ScienceDirect, PubMed, SAGE, Sringer link, Web of Science and Wiley Online Library. It was limited to full text research articles that report intervention studies, written in English Language, published between 2003 to 2022. The key words were “malaria”, “malaria prevention”, “health education”, “insecticide-treated nets”, “utilization”, “pregnant women”. Results: A total of eleven articles met the inclusion criteria and included in the review. Six studies reported randomized controlled trial (RCTs) while five studies reported non-randomized controlled trial (NRCT). Conclusions: There are evidences that health education programs improve ITNs, LLINS utilizationamong pregnant women. Furthermore, additional interventions directed at significant others need to be implemented, considering the important role they play in determining pregnant women’s use of ITNs, LLINs.
The Effect of Strain on Hydrogen StorageCharacteristics in K2NaAlH6 double Perovskite Hydride through First-principles method
Authors: Baadi Malika , Chami Rachid , Baalla Oumaima , Quaoubi Soukaina El , Saadi Ali , Omari Lhaj El Hachemi , Chafi Mohammed 
Published: March 2023

Abstract
Today hydrogen is considered one of the most credible options for a non-polluting, carbon-free energy carrier. Hydrogen can be obtained or produced by different means from different renewable energy sources and can be stored in solid, liquid, or gaseous form. Storing hydrogen in complex hydrides in solid form is one of the most efficient methods of storage because they are secure, offer high hydrogen capacity, and demand optimal functioning conditions. Complex hydrides give a large gravimetric capacity that allows large amounts of hydrogen to be stored. This study examined the effects of uniaxial and biaxial strains on the properties of the Perovskite-type compound K2NaAlH6. The analysis was conducted through first principales calculations using the full potential linearized augmented plane waves (FP-LAPW) approach. The results showed that both compressive and tensile strains led to significant structural deformation in the K2NaAlH6 crystal structure, which became more pronounced as the magnitude of the strain increased or decreased. This deformation reduced the stability of the compound, resulting in a marked decrease in its dehydrogenation enthalpy and decomposition temperature. The values under maximal biaxial compression strain of ε ≈ 5% were -40.14 KJ/mol.H2 and 308.72 K, respectively, compared to the original values of -62.98 KJ/mol.H2 and 484.52 K. The analysis of the densities of states showed that changes in the dehydrogenation and structural properties of K2NaAlH6 were closely linked to the Fermi level value of the total densities of states. These findings provide valuable insights into the potential of K2NaAlH6 as a hydrogen storage material.
Excess explosivity driven by melt inclusions during the 946 CE Plinian eruption of Baekdusan
Authors: Gi-Bom Kim , Cronin Shane , Jeong Jong Ok , Go Sun Young , Lee Youn Soo , Liu Jiaqi , Sohn Young Kwan 
Published: March 2023

Abstract
This study reports a unique pumice texture generated by the instantaneous bursting of melt inclusions in alkali feldspars during the 946 CE Plinian eruption at Baekdusan. The burst produced super-vesicular (80−90 vol.% voids), subspherical (i.e., non-sheared), and subcentimeter-sized “bubble pockets” indicating their formation at the moment of magma fragmentation. Their volume fraction (6–24 vol.%) suggests that the melt inclusions acted as an additional volcanic gas source and increased significantly the volume of the erupting magma at the moment of magma fragmentation. The “excess explosivity” induced by the bursting melt inclusions should be taken into account when modeling eruption dynamics and assessing volcanic hazards, therefore having broad volcanological implications. Two distinctive feldspar–glass assemblages of either sanidine-bearing trachyte or anorthoclase-bearing rhyolite in the bubble pockets also indicate that the chemical bimodality of the hemisphere-scale, 946 CE Baekdusan tephra resulted from cryptic mixing of two magmas.
Placental chorioangioma and pregnancy outcome: A ten-year retrospective study in a tertiary referral centre
Authors: Hongwei Ma , Ziling Liu , Jie Ruan 
Published: March 2023

Abstract
Background
Placental chorioangioma is a rare disorder in pregnancy. We retrospectively reviewed the perinatal complications and long-term outcomes in pregnancies with placental chorioangioma and evaluated the factors affecting disease prognosis.
Methods
We reviewed pregnant women who delivered at our hospital in the past decade and whose diagnosis of placental chorioangioma was confirmed by pathological diagnosis. Information on maternal demographics, prenatal sonographic findings and perinatal outcomes was obtained by reviewing the medical records. In the latter part of the study, follow-up of children was conducted by phone interview.
Results
In the 10 years from August 2008 to December 2018, 175 cases(0.17%) were identified as placental chorioangioma histologically and 44(0.04%) of them were large chorioangiomas. Nearly one-third of cases with large chorioangiomas were associated with severe maternal and fetal complications or required prenatal intervention. Although one-fifth of fetuses/newborns complicated with large chorioangiomas were lost perinatally, the long-term prognosis for surviving fetuses was generally good. Further statistical analysis revealed that tumor size and location affect prognosis.
Conclusion
Placental chorioangioma may cause an unfavorable perinatal outcome. Regular ultrasound monitoring can provide the tumor characteristics which can be referred to for predicting the tendency of those complications and indicate when intervention may be necessary. It is not clear which factors lead to complications with fetal damage as the main manifestation or polyhydramnios as the main manifestation.