bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of TERC inhibits neural apoptosis and inflammation in spinal cord injury through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis
Authors: Ding Weiguo , Xu Weixing , Lu Di , Sheng Hongfeng , Xu Xinwei , Xu Bin , Zheng Aote 
Published: January 2023

Abstract
This study investigated the function of telomerase RNA component (TERC) in spinal cord injury (SCI). SCI models were established in rats via laminectomy and PC-12 cells were treated with lipopolysaccharide (LPS). TERC and miR-34a-5p expressions in cells and rat spinal cords were detected by quantitative reverse transcription polymerase chain reaction, followed by overexpression/knockdown of TERC/miR-34a-5p. Spinal cord histopathological changes were examined via hematoxylin–eosin staining. miR-34a-5p′ relation with TERC and XBP-1 was predicted by TargetScan and checked by dual-luciferase reporter/RNA immunoprecipitation assays. Cell biological behaviors were assessed by Cell counting kit-8, wound healing, Transwell, and flow cytometry assays. XBP-1 and inflammation/apoptosis-related protein expressions were analyzed by western blot. TERC was upregulated and miR-34a-5p was low-expressed in SCI tissues and LPS-induced PC-12 cells. TERC-knockdown alleviated histopathological abnormalities yet upregulated miR-34a-5p in SCI tissues. In LPS-induced PC-12 cells, TERC knockdown promoted cell viability, migration, invasion, and inhibited apoptosis, while TERC overexpression ran oppositely. TERC knockdown downregulated the XBP-1, IL-6, TNF-α, Bax, p-p38/t-p38, and cleaved caspase-9/-3, but upregulated Bcl-2 and p-Akt/t-Akt. TERC targeted miR-34a-5p, which further targeted XBP-1. miR-34a-5p downregulation exerted effects opposite to and offset TERC knockdown-induced effects. TERC knockdown facilitated the regeneration of neuron tissues yet inhibited inflammation in SCI through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis.
Authorities at play in Indigenous language reclamation: tensions and possibilities in the Yucatan Peninsula
Authors: Anzures Aldo , Kvietok Frances 
Published: January 2023

Abstract
Language revitalization efforts have been critiqued for creating and reproducing linguistic, epistemological, and pedagogical hierarchies that might run counter to a community’s needs and interests. Drawing on a seven-year ethnographic and collaborative research with the Maya cultural promoters of the Caste War Museum in Tihosuco, Mexico, we describe the dynamics of our Maya language reclamation partnership focusing on the creation of bilingual comic books and summer workshops for children. These experiences show a slow but steady language reclamation approach based on the concern for younger generations to feel comfortable to claim their right to speak and learn Maya and on their fondness for Maya language and culture. We argue that the construction, negotiation, and assertion of linguistic and pedagogical authority among all participating actors is central to reclamation projects, and that these processes are impacted by outsider researchers-collaborators in ways that can support but also potentially harm these language efforts. This paper sheds light on the various tensions lived in long-term language reclamation projects, recognizing the need for outsider researchers to turn our reflexive gaze inwards and consider how we can bring to the fore practices we can celebrate as well as address and transform those that cause discomfort and uncertainty.
Anomalous dips in reflection spectra of optical polymers deposited on plasmonic metals
Authors: Shorter Ayanna , Chowdhury Md Golam Rabbani , Rout Sangeeta , Noginov Mikhail A. 
Published: January 2023

Abstract
We have studied reflection spectra of dye-doped and undoped polymers deposited onto Ag and Au substrates and found anomalous dips in the UV spectral range. On top of Ag substrates, the λ ∼ 375 nm dips were observed in undoped PMMA, PVP, and PS polymers as well as PMMA doped with Rh590 and HITC laser dyes. In silver-based samples, the spectral positions of the observed reflection dips were close to singularities in the refractive indexes of surface plasmon polaritons (SPPs) propagating at the interface between Ag and polymer. The latter singularities can tentatively explain the λ ∼ 375 nm reflection dips, if the scattering of Ag and polymeric films is large enough to launch SPP without any prism or grating. The dips observed in reflection of Rh590:PMMA and HITC:PMMA on top of Au, were more pronounced than those on Ag, broader, shifted to shorter wavelengths, and their spectral positions had large standard deviations. Furthermore, no anomalous dips in gold-based samples were observed in the reflection spectra of undoped PMMA, PVP, and PS polymers, and a modest singularity in the SPP refractive index, predicted theoretically at λ ∼ 500 nm, cannot explain the dips in the UV reflection spectra observed experimentally. It appears likely that the origin of the reflection dips on top of Au substrates is different from that on top of Ag substrates.
The crystal structure of 3-hydroxy-2-nitroestra-1,3,5(10)-trien-17-one, C18H21NO4
Authors: Raičević Vidak , Radnović Nikola D. , Rodić Marko V. , Radulović Niko S. 
Published: January 2023

Abstract
C18H21NO4, orthorhombic, C2221 (no. 20), a = 10.6891(2) Å, b = 11.8375(2) Å, c = 25.4410(4) Å, V = 3219.11(10) Å3, Z = 8, R
gt(F) = 0.0483, wR
ref(F
2) = 0.1449, T = 295 K.
Increased risk of mortality from COVID-19 in people with obesity
Authors: Ribeiro Ana Cristina , Poli Priscila , Uehara Silvia Carla da Silva André 
Published: January 2023

Objective: to analyze the risk of mortality from COVID-19 in people with obesity. Methods: observational, retrospective, and analytical study. Data were collected in the State System of Data Analysis. For the comparative analysis of people with and without obesity, n=168,808 was adopted. The analyses were performed using the log-binomial regression model and relative risk calculation. The comparative model was adjusted for sex, age group, heart disease and diabetes. Results: in more than 95% of COVID-19 notifications, information regarding the risk factor obesity was recorded as ignored. Obese individuals with COVID-19 had 26% higher risk of death when compared to those without obesity. Obese individuals in the 11 to 60 age groups had the highest mortality risks compared to individuals without obesity. Obese women in the age groups 31 to 50 years and elderly women over 71 years had the lowest mortality risk when compared to obese men. Conclusion: obese people, especially adults, have an increased risk of mortality from COVID-19. Contributions to practice: to help establish public health strategies to identify the profiles of individuals considered at high risk in the SARS-CoV-2 pandemic.
Perkembangan Pondok Pesantren Modern Darul Ulum Muara Kiawai Kecamatan Gunung Tuleh Kabupaten Pasaman Barat Tahun 1998-2018
Authors: Sermal Sermal , Islami Yana 
Published: January 2023

Skripsi ini berjudul “Perkembangan Pondok Pesantren Darul Ulum muara Kiawai Kecamatan Gunung Tuleh Kabupaten Pasaman barat Tahun 1998-2018”. Penelitian ini dilatarbelakang dari lembaga pendidikan Agama di Nagari Muara Kiawai yang berbentuk Pondok Pesantren yang berstatus swasta dan berakretasi C. semua masyarakat umum mengetahui adanya Pondok Pesantren di daerah nagari Muara Kiawai ini. Awal berdirinya Pondok Pesantren ini hanya memiliki Satuan Pendidikan yaitu tingkat Madrasah Tsanawiyah yang terus berkembang dan didaerah ini sudah banyak terdapat sekolah-sekolah umum dan lembaga pendidikan agama seperti MTs dan, SMK Jurusan Teknik Komputer. Dilihat dari sejarah Pondok Pesantren Darul Ulum Muara Kiawai merupakan Pondok Pesantren yang tertua dan unik dari Pesantren ini adalah adanya SMK Jurusan Teknik Jaringan yang berkembangan sangat pesat.Sedangkan rumusan masalah penelitian ini adalah bagaimana sejarah berdiri dan perkembangan Pondok Pesantren Darul ulum Muara Kiawai Pasaman Barat pada tahun 1998 – 2018, dan batasan yang digunakan adalah batasan temporal, batasan spasial, dan batasan tematik.Penelitian ini bersifat kualitatif dan menggunakan metode penelitian sejarah yang terdiri dari beberapa langkah yaitu heuristik, kritik sumber, interpretasi dan historiografi.Dari hasil penelitian ditemukan bahwa sejarah berdirinya Pondok Pesantren Modern Darul Ulum Muara Kiawai Pasaman Barat ini berdiri selama 20 tahun oleh 9 tokoh bernama A. Sarmin Lubis pada tanggal 31 Juli 1998Adapun perkembangan Pondok Pesantrenyang telah mengalami dua kali masa kepemimpinan dan setiap kepemimpinan mengalami perubahan dan pengikatan, baik dibidang guru, siswa, kurikulum, jumlah santri yang lulus, Sarana prasarana di Pondok Pesantren. Adapun perubahan yang terjadi pada tahun pertama tidak terlalu meningkat Kurikulum masih KTSP, denganjumlah santri 10 orang, 18 orang guru, jumlah santri yang lulus 10 orang, dan saran prasarana juga terbatas. Tahun selanjutnya Pondok Pesantren Darul Ulum Muara Kiawai mengalami peningkatan dari tahun sebelumnya dikarenaka sekolah ini semakin banyak dikenal orang dan bertambah banyak siswa yang masuk, sarana prasarana semakin bertambah. Intinya setiap tahun di Pondok Pesantren Darul Ulum Muara Kiawai mengalami perubahan meskipun secara bertahap dari tahun ketahun.
Perjuangan Haji Agus Salim pada Masa Pergerakan Nasional (1915-1945 M)
Authors: Sermal Sermal , Rahma Ezi Fauzia 
Published: January 2023

Beberapa strategi konstruktif yang diterapkan berdampak positif bagi masyarakat sekitar. Pesantren Dr.Muhammad Natsir punya kapasitas mengangkat taraf hidup, mengurangi tingkat pengangguran dan kemiskinan masyarakat sekitar melalui program padat modal, padat karya, penanggulangan anak putus sekolah. Melalui pengembangan usaha ekonomi produktif masyarakat sekitar mengenal jenis tanaman baru dan pekerjaan baru sehingga kesejahteraan mereka bisa terangkat dan dapat mempercepat usaha pemerintah dalam menanggulangi kemiskinan dan pengangguran di wilayah perdesaan. Penelitian ini bertujuan perjuangan Haji Agus Salim pada masa pergerakan. Metode yang digunakan untuk mencapai tujuan yang telah ditetapkan adalah metode (Library Research) atau studi pustaka dengan langkah-langkah menyiapkan data dan sumber data, teknik pengumpulan data, teknik analisis data. Hasil penelitian ditemukan bahwa Perjuangan politik Haji Agus Salim dalam Sarekat Islam yaitu, Agus Salim merumuskan asas dan tujuan sarekat Islam (SI) dengan menyusun rancangan keterangan asas (Beginsal Verklaring) dan disahkan pada kongres luar biasa CSI tahun 1921. Agus Salim menjadi tokoh penting dan berpengaruh dalam mengariskan kebijakan dan strategi perjuangan Sarekat Islam. Agus Salim seorang yang mengetahui pikiran-pikiran Barat, tetapi dialah pemimpin SI yang paling mengetahui tentang Islam dan sumber aslinya. Peranan Agus Salim yang sangat dominan dan menentukan adalah dalam hal membersihkan golongan komunis dari Sarekat Islam. Perjuangan Agus Salim dalam Volksraad Haji Agus salim berperan sebagai anggota volksraad selama 3 tahun, pada tahun (1921-1924) dan mewakili Sarekat Islam. Sebagai Anggota Volksraad Haji Agus Salim Berhasil menunjukkan dirinya sebagai pembicara yang ulung, ahli debat serta berani melancarkan kritik-kritik yang tajam terhadap kebijaksanaan-kebijaksanaan pemerintah kolonial Belanda., Perjuangan Haji Agus Salim dalam dunia pers dalam artikel Surat Kabar Neratja Agus Salim mempengaruhi dan membangkitkan semangat masyarakat agar tidak mengharap balas kasian bangsa penjajah, sebagai pemimpin Surat Kabar Hindia baru dan Neratja.
Sejarah dan Nilai-Nilai yang Terdapat dalam Tradisi Bakatik Adat di Nagari Barung-Barung Balantai Kabupaten Pesisir Selatan
Authors: Mardison Safri , Fitri Wahyuni 
Published: January 2023

Tujuan penulisan artikel ini adalah untuk mengetahui dan mendeskripsikan sejarah bakatik adat, proses pelaksanaan bakatik adat dan nilai-nilai yang terkandung dalam tradisi bakatik adat. Metode penelitian yang digunakan dalam penulisan ini adalah metode penelitian sejarah yang terdiri dari peberapa langkah yaitu: heuristik, kritik interpretasi histografi. Teknik pengumpulan data dengan metode observasi, wawancara dan studi dokumentasi. Batasan yang digunakan adalah batasan temporal, spasial dan tematik. Berdasarkan hasil penelitian ditemukan bahwa: Pertama, Sejarah tradisi bakatik adat dimulai tahun 1955 oleh ke empat suku yaitu suku Tanjuang oleh Dt. Rangkayo Mudo, suku Melayu oleh Dt. Manggih, suku Jambak oleh Dt. Patiah dan suku Caniago oleh Dt. Mandaro. Mereka berempat bersepakat di atas balai rumah nan gadang untuk membuat acara bakatik adat sebagai silaturahmi antara perantau dengan orang kampung; Kedua, proses bakatik adat dibagi kepada tiga tahap. Tahap pembukaan berupa penyambutan bagi kepala daerah (bupati beserta rombongan dan para perantau khususnya) dengan tarian pasambahan diikuti dengan kata sambutan oleh bupati, wali nagari, perantau dan ketua KAN. Tahap kedua isi (penyampaian bakatik adat oleh katik), tahap terakhir adalah penutup berisikan doa dan acara hiburan berupa kesenian daerah yang ada di Minangkabau. Panitia pelaksana bakatik adat ini adalah keempat suku (suku Melayu, suku Jambak, suku Tanjuang dan suku Caniago) secara bergiliran dan waktu pelaksanaannya setiap hari kedua atau hari ketiga dihari raya idul fitri; Ketiga, isi dari bakatik adat tentang penyampaian nasehat nasehat kepada anak kemenakan. Nilai-nilai yang terkandung dalam tradisi bakatik adat adalah nilai akidah, nilai ibadah, akhlak dan nilai sosial.
E-Modul Berbasis Hypercontent: Upaya untuk Mengatasi Kesulitan Pembelajaran Sejarah di Masa Pandemi Covid-19
Authors: Marta Nuraeni , Djunaidi Djunaidi , Iriani Corry 
Published: January 2023

This article aims to review efforts to overcome the difficulties of learning history during the COVID-19 pandemic through teaching materials in the form of hyper-content-based e-modules. The Research qualitative methods, the main data is obtained from the results of in-depth interviews with key and core informants. Since mid-March 2020, face-to-face learning has been abolished and replaced by distance learning online. Teachers and students are forced to suddenly switch and adapt to using digital devices. This sudden change resulted in "uncertainty" in the process of implementing history learning. One of the reasons is that there are still many technologically stuttering students and teachers. For history teachers, one of the difficulties encountered during the pandemic was the difficulty of teaching the material completely. They also find it difficult to develop varied learning methods so that the material can be comprehensively understood so that students are able to interpret and use it in life. This is exacerbated by the difficulties and technical constraints often encountered in online learning. Alternative learning aids are needed to overcome this problem, especially regarding material and technical constraints. The development of hyper-content-based e-modules can be an alternative solution. Teaching materials in the form of hyper content-based e-modules are teaching materials consisting of text, images, sounds and hyperlinks packaged with a digital platform. Hypercontent-based e-modules have advantages: lightweight and easy access, so students can learn the material without being limited by space and time. In addition, hyper-content e-modules that are packaged are not only in the form of text but also include sound and images, making it easier for students to understand the material. The results showed that hyper content-based e-modules help students learn independently, can be done anytime and anywhere and lighten the burden of student learning.
Adolescents’ Digital activity and its Correlation with Cognitive-Emotional Features, School Performance, and Social and Age Factors: Cross-Sectional Study
Authors: Karkashadze George A. , Sergeeva Natalia E. , Namazova-Baranova Leyla S. , Vishneva Elena A. , Kaytukova Elena V. , Efendieva Kamilla E. , Gogberashvili Tinatin Yu. , Kratko Dmitriy S. , Sadilloeva Safarbegim Kh. , Kurakina Marina A. , Rykunova Anastasiya I. , Konstantinidi Tatiana A. , Ulkina Nadezhda A. , Bushueva Daria A. , Povalyeva Inessa A. , Yatsyk Leonid M. , Salimgareeva Tatiana A. , Nesterova Yuliya V. , Prudnikov Pavel A. , Sergienko Natalia S. , Soloshenko Margarita A. , Shilko Nikita S. , Kazantzeva Yuliya E. 
Published: January 2023

Background. The study of digital activity correlation with cognitive-emotional features, as well as with other parameters of adolescents’ life-activity in non-capital regions of Russian Federation remains relevant.Objective. The aim of the study is to analyze the digital activity structure in adolescents and its correlation with cognitive-emotional features, school performance and social and age factors.Methods. Participants are secondary school students of the 8th–11th grades. Digital activity was examined via online survey among adolescents. We took into account the use of social media, information search, watching videos on the Internet, using of messengers, playing games with electronic devices. Cognitive features (memory, thinking, executive functions, sensory information procession, reading and speech, understanding of emotions, decision-making) and emotional state of adolescents (anxiety) were evaluated by clinical psychologists via various tests. School performance was determined by the recent results of the school quarters/semester finished by the time of the survey. Social and age factors included regular out-of-school physical activity and family structure (complete/ incomplete).Results. We have examined 438 teenagers. 53 (12%) respondents spend more than 5 hours a day with digital devices on weekdays, 133 (30%) — on weekends, 147 (34%) — during the holidays. Structure of digital activity during weekdays (≥ 1 hour) among adolescents was the following: activity in social media prevailed (63.5% of respondents), fewer teenagers searched for information or watched videos on the Internet (47.3 and 42.9%, respectively), about a third (34.9%) played via electronic devices. Structure of digital activity changed over the weekend and during the holidays. We have revealed differences between the information search activity and the volume of short-time memory, understanding the verbal messages, and verbal-logical operations level. Adolescents with different levels of computer gaming activity have shown diversity in sensomotor reaction speed, visuospatial memorization accuracy, number of errors in high-speed reading, reading pace, and understanding text basic meaning.Conclusion. The greater time of digital activity among 8th–11th grades students is associated with negative results of cognitive activity and school performance.
Unified system and classification of indicators for integral assessment of the performance and effectiveness of medical care organization at the regional level in the Russian Federation
Authors: Omelyanovskiy V. V. , Mikhailov I. А. , Lukyantseva D. V. , Samsonova Е. S. , Lebedenko G. G. 
Published: January 2023

Objective: development of a unified system and classification of indicators for an integral assessment of performance and effectiveness of the organization of medical care (MC) at the regional level in the Russian Federation (RF).Material and methods. A systematic search for domestic and foreign scientific publications and a comprehensive analysis of the current regulatory legal acts in the field of health care for the presence of indicators characterizing the effectiveness of MC organization in the RF regions were performed. The search for indicators of effectiveness was carried out in analytical reports based on the results of field events of national medical research centers (NMRC) in the constituent entities of the RF for 2019, 2020 and 2021 in various profiles of MC. In total, 3019 analytical reports on the results of field events and 97 annual public reports on the results of the NMRC activities were analyzed.Results. Three options for classifying indicators were formed: according to the method of obtaining (primary, calculated, secondary qualitative); in relation to the final result (resulting, process (surrogate)); classification of parameters that determine the MC system, including in the context of profiles, forms, types, conditions of MC (18 positions). The proposed unified system and classification of indicators has a number of advantages compared with the Organisation for Economic Cooperation and Development, Centers for Medicare & Medicaid Services and Commonwealth Fund indicators adopted in a number of countries. It was established that international systems use mainly resulting indicators, while the domestic health care system uses exclusively process indicators that are not combined into a single system and are monitored by various departments.Conclusion. The presented approach to a unified system and classification of indicators for an integrated assessment of performance and effectiveness of MC organization allows to determine the priorities for the development of a monitoring system. At the same time, it should be noted that this approach requires further discussion and improvement.
Investigations of Ambient Noise Velocity Variations in a Region of Induced Seismicity near Greeley, Colorado
Authors: Clifford Tom , Sheehan Anne , Moschetti Morgan P. 
Published: January 2023

Abstract
Wastewater injection has induced earthquakes in Northeastern Colorado since 2014. We apply ambient noise correlation techniques to determine temporal changes in seismic velocities in the region. We find no clear correlation between seismic velocity fluctuations and either injection volumes or seismicity patterns. We do observe apparent annual variations in velocity that may be associated with hydrologic loading or thermoelastic strain. In addition, we model uniform and vertically localized velocity perturbations, and measure the velocity change with 1D synthetic seismograms. Our results indicate that our methods underestimate the known velocity change, especially at shorter station distances and when variations are restricted to a horizontal layer. If injection does cause measurable velocity changes, its effect is likely diluted in cross correlations due to its localized spatial extent around injection wells.
The Effect of Fiscal Decentralization on Economic Development Performance in Indonesia
Authors: Armawaddin Muhamad , Rumbia Wali Aya , Ahmad Ahmad 
Published: January 2023

The purpose of this study is to test and analyze the influence of fiscal decentralization on development performance in Indonesia using the structural equation model approach. The data uses panel data, from 34 provinces and in 2015-2019 sourced from the Ministry of Finance of the Republic of Indonesia and the Central Bureau of Statistics (BPS). Data analysis using structural equation model approach with the help of Smart-PLS 3.3.3 software. The outer model evaluation results concluded that all indicators of fiscal decentralization variables and economic development performance variables are valid. The most powerful indicator reflecting the latent variable of fiscal decentralization is the ratio of regional income and economic development performance is an indicator of economic growth. The results of the evaluation of the inner model found that fiscal decentralization performance has a positive and significant influence on development performance. The existence of fiscal inequality among provinces in Indonesia causes uneven ratios of capital expenditures and public incomes as seen from the low indicator in reflecting decentralization of fiscal and economic performance