bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time–Space Evolution of the Groningen Gas Field in Terms ofb-Value: Insights and Implications for Seismic Hazard
Authors: Gulia Laura 
Published: April 2023

AbstractThe Groningen gas field, located in the northeast of The Netherlands, is the Europe’s largest onshore gas field. It was discovered in 1959 and production started in 1963: Continuous production leads to reservoir compaction and subsidence, gradually loading preexisting fault and induced seismicity that started about 30 yr into the production. The seismic hazard and risk related to the induced seismicity is determined not only for the rate of activity, but it is also equally influenced by the relative size distribution of the seismicity—the b-value. I reanalyze the spatial and temporal evolution of the b-value in the field using an alternative approach to overcome magnitude in completeness heterogeneity, and link it to the evolution of fault loading and subsidence. Spatial variations of b-values are found to vary between 0.61 and 1.3, with the lowest observed values observed in the location of the 2012 M 3.6 Huizinge earthquake. In the last 10 yr, the mapped b-values are more homogeneous throughout the field. The spatial and temporal evolution of the b-value in the field in this study is shown to be quite complex, and systematically linked it to the evolution of fault loading, absolute compaction, and the rate of compaction—an important finding that offers new insights into hazard reduction and mitigation strategies of extraction relation-induced seismicity. Compaction rates below 2 mm/yr are not correlated to seismicity above M 2.0 in the history of the field, suggesting that low-volume production may be safer than that previously assumed.
Modelagem computacional: uma aproximação entre artefatos cognitivos e experimentos virtuais em Física
Authors: Rodrigues Gil Luna , Tavares Romero 
Published: April 2023

<p>Este trabalho propõe estruturar e analisar uma metodologia, associando o paradigma teórico a aprendizagem significativa de David Ausubel, e o uso do computador como ferramenta de modelação, para mediar a construção do conhecimento na disciplina Física, condicionando um processo que envolve a aprendizagem e seus agentes formadores. Seguindo a tendência da teoria de ausubeliana, foi dada a relevância pertinente para uma sequência das ações: mapeamento do entendimento prévio (subsunçores) do aprendiz no eixo temático a ser desenvolvido; apropriação do conte ̇do ideacional mediada com a apresentação das Animações Interativas; avaliação processual da aprendizagem; construção do conhecimento de forma compartilhada, priorizando os princípios básicos da conexão, da heterogeneidade e da pluralidade, implementados com o uso e a construção dos objetos de aprendizagem, permeadas pelos signos da multimídia interativa numa aproximação entre artefatos cognitivos e experimentos virtuais. Enfim, trata-se de um processo dinâmico de aprendizagem, apontando para o fato de que os conceitos não são alvos estáticos na aprendizagem, mas uma teia que evolui na estrutura cognitiva do aprendiz.</p>
Ferramenta de auxílio ao aprendizado de phrasal verbs a estudantes de Língua Inglesa
Authors: Oliveira Jorge Antônio Monteiro Corrêa de , Oliveira Robson Ytallo Silva de 
Published: April 2023

<p>O conhecimento da língua inglesa tem se tornado indispensável nos dias de hoje, devido à globalização, tendo como uma de suas maiores dificuldades de assimilação o estudo de Phrasal Verbs, que é uma particularidade de combinações de verbos e expressões do idioma. Este trabalho visa subsidiar uma nova metodologia de ensino para Phrasal Verbs. Será desenvolvido um aplicativo que reunirá dicionário, atividades, simulados e jogos utilizando-se de recursos audiovisuais. Pretende-se, assim, obter um maior grau de satisfação no aprendizado desse conte ̇do no estudo da língua inglesa.</p>
Perspectives and settings for teaching reading
Authors: Araújo Marcus De Souza 
Published: April 2023

<p>Reading a text allows a variety of interpretation by different readers, governed by factors such as purposes, background knowledge, and the relationship between the reader and the text. This paper presents some pedagogical implications to the teaching of reading in a foreign language. Therefore, in order to help foreign language teachers, we present an overview of some relevant aspects to the teaching of reading in a dynamic and interactive setting.</p>
Recovery para uma Vida Cotidiana de Protagonismo em Saúde Mental
Authors: Rodrigues Malcher O. Silva Maria de Nazareth 
Published: April 2023

Um cotidiano de autonomia considera-se como um marco para o sucesso da reabilitação psicossocial da política a saúde mental. Em contrapartida, a hospitalização e rotina reduzida em atividades, reduzindo a pessoa apenas às atividades nos serviços substitutivos, tem gerado, processualmente, rupturas,distanciamento de uma cotidianidade de interferências em ocupações e protagonismo. Desta forma, o sentido está em criar estratégia de Recovery como postura relevante para saúde mental, e que foi observadana entrevista de Livia, usuária da saúde mental, com descrição de um cotidiano autônomo, protagonista, sem estar reduzido no tratamento psiquiátrico medicamentoso e terapêutico. Neste sentido, sua entrevistadesenha para nós seu processo em saúde mental, desconstruindo a lógica de tratamento apenas pela cura dos sintomas, mas de um cotidiano ativo, refletido pelo paradigma de Recovery, pela superação ao estigmahistoricamente instituído do louco, por meio de ações em saúde holística, de empoderamento e exercício da cidadania, mostrando a necessidade de políticas robustas ampliadas do campo médico e da vida social, comotambém de estímulo ao discurso e à sabedoria popular.Palavras Chave: Autonomia. Protagonismo. Cotidiano. Saúde mental. Recovery.
Nonsurgical Interventional Spine Pain Procedures
Authors: Whitaker Colin D. , Stone Benjamin K. , Gregorczyk Jerzy A. , Alsoof Daniel , Hardacker Kyle , Diebo Bassel G. , Daniels Alan , Basques Bryce 
Published: April 2023

» Nonsurgical interventional spine pain procedures provide an additional treatment option for lower back pain at the traditional bifurcation of conversative vs. operative management.» Transforaminal epidural steroid injections, radiofrequency ablations, intrathecal drug delivery, and spinal cord stimulation were found to be effective and safe techniques when applied to their specific indication.» Thermal annuloplasty and minimally invasive lumbar decompression showed mixed support.» Discography, sacroiliac joint injections, and spinous process spacers lacked sufficient evidence to support efficacy.» Medial branch blocks and facet joint injections were found to be useful diagnostic tools.
Los medios de comunicación y el terrorismo yihadista: análisis terminológico aplicado a la traducción (DE-ES)
Authors: Montes Sánchez Alba 
Published: April 2023

El terrorismo se contempla como un factor complejo que se ha abordado desde numerosos ámbitos de estudio, destacando trabajos sobre el concepto de terrorismo global y yihadismo. No obstante, los trabajos relacionados con la terminología, la traducción o la lingüística aplicada son escasos en esta área. Asimismo, el léxico empleado por los medios de comunicación al abordar contenido relacionado con el terrorismo ha suscitado un gran interés en las investigaciones que hemos desarrollado recientemente. El presente estudio aborda el léxico y la terminología del ámbito del terrorismo desde un enfoque traductológico. Para ello, partimos de un breve análisis sobre el tratamiento que hacen los medios de comunicación de este léxico. En esta comunicación se pretende analizar y resolver las cuestiones lingüísticas que se originan en alemán y español desde una perspectiva traductológica, con el objetivo fundamental de evidenciar el volumen de términos, abreviaturas, siglas y acrónimos que emplea la prensa alemana y española en este campo de especialidad.

Terrorism is considered a complex factor that has been approached from numerous fields of study, specially works on the concept of global terrorism and jihadism. However, researches related to terminology, translation or applied linguistics are scarce in this area. Also, the lexicon used by the media when dealing with terrorism-related content has aroused great interest in the research we have recently developed. This research addresses the lexicon and terminology of the field of terrorism from a translational approach. To do this, first, it is presented a brief analysis about the treatment of this lexicon by the media. This study aims to analyze and solve the rising linguistic questions in German and Spanish from a translation perspective, with the main objective of evincing the volume of terms, abbreviations and acronyms used by the German and Spanish press in this field of expertise
Oral challenge vs routine care to assess low-risk penicillin allergy in critically ill hospital patients (ORACLE): a pilot safety and feasibility randomised controlled trial
Authors: Rose Morgan , Holmes Natasha , Eastwood Glenn , Vogrin Sara , James Fiona , Phung Michelle , Barnes Sara , Murfin Brendan , Rogers Ben , Lambros Belinda , Peel Trisha , Gibney Grace , Slavin Monica , Trubiano Jason 
Published: April 2023

Abstract
Background: Self-reported penicillin allergies are highly prevalent in hospitalised patients and are associated with poor health and health service outcomes. Critically ill patients have historically been underrepresented in prospective delabelling studies in part due to concerns around clinical stability and reliability of penicillin skin testing. Allergy assessment tools exist to identify low-risk penicillin allergy phenotypes and facilitate direct oral challenge delabelling. PEN-FAST is a clinical decision rule that has been validated to predict true penicillin allergy in a cohort of non-critically ill patients. There is however limited evidence regarding the feasibility, safety, and efficacy of direct oral challenges and the use of delabelling clinical decisions rules in the intensive care setting.
Methods: Critically ill patients in the Intensive Care Unit (ICU) with low-risk penicillin allergy phenotypes (PEN-FAST score < 3) will be randomised 1:1 to direct oral penicillin challenge (single dose 250mg oral amoxicillin or implicated penicillin) or routine care, followed by a 2-hour observation period. Patients will receive a second oral challenge/observation prior to hospital discharge (with subsequent observation for 2 hours). An assessment for antibiotic-associated adverse events will also be undertaken at 24 hours and 5 days post each challenge/observation and again at 90 days post-randomisation. The primary outcome measures are feasibility (proportion of eligible patients recruited and protocol compliance) and safety (proportion of patients who experience an antibiotic-associated immune mediated adverse event or serious adverse event).
Discussion: We will report the feasibility and safety of point-of-care penicillin direct oral challenge in this first randomised controlled trial of low-risk penicillin allergy in critically ill hospitalised patients. Upon completion of the project, important findings will inform the design of planned large prospective multi-centre clinical trials in Australian and international ICUs, further examining safety and efficacy and exploring antimicrobial prescribing-related outcomes following penicillin oral challenge.
Trial registration
Australian New Zealand Clinical Trials Registry
Registration Number: ACTRN12621000051842
Date Registered: 20/01/2021
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379735&isReview=true
Version
V 7 09/DEC/2021
Chloroplast Small Heat Shock Protein CsHSP24.6 of Tea Plants Positively Regulates Heat, Light, and Salt Stress Tolerance
Authors: Wang Haiyan , Ma Jing , Han Xueying , Zhu Mengqing , Luo Yuanyuan , Chen Yifan , Fu Zhouping , Ma Guoliang , Gao Liping , Xia Tao 
Published: April 2023

Abstract
Small heat shock proteins (sHSPs) function as molecular chaperones, which play crucial roles in plant growth, development, and stress response. However, the function of the sHSP gene in the tea plant (Camellia sinensis L.) has not been extensively investigated. In total, 54 C. Sinensis small heat shock proteins (CssHSPs) in the tea plant genome were screened. Phylogenetic analysis revealed that CssHSPs in the same group have similar conserved domains and motifs; conversely, significant structural differences exist in the different groups. Most CssHSP genes had tissue-specific expression. They also responded to one or more abiotic or biotic stresses, CsHSP24.6 was selected for functional analysis. The results demonstrated that the expression of CsHSP24.6 increased under abiotic stresses such as temperature, light intensity, and NaCl. In addition, under high temperature and high light intensity treatments, CsHSP24.6 and its target gene CspTAC5 interacted to enhance the heat and light resistances of the plant. CsHSP24.6 facilitates resistance to abiotic stresses in tea plants. These results further support that CsHSP24.6 plays an essential role in maintaining plant growth and development under abiotic stress.
Influence of phylogenetic diversity of plant communities on plant-herbivore-natural enemies interactions
Authors: Alavez Verónica , Santos-Gally Rocio , Gutiérrez-Aguilar Manuel , del-Val Ek , Boege Karina 
Published: April 2023

Abstract
Phylogenetic diversity of plant communities can influence the interaction between plants, herbivores and their natural enemies. Plant communities with phylogenetically distant species tend to present a wide variety of functional traits and ecological niches, which in turn can influence competitive interactions among plants as well as food and habitat quality for herbivores and their natural enemies. To assess the different mechanisms by which phylogenetic diversity of plant communities may influence herbivores and their natural enemies, we established 12 experimental plots of tropical trees with two treatments: high and low phylogenetic diversity. We measured plant growth, and anti-herbivore defenses, herbivore foliar damage, and predator activity in seven species that were present in both treatments. We found significant differences in the expression of plant traits as a function of species identity and their life history, but also depending on the phylogenetic context in which they grew. Pioneer species had higher growth and greater phenolic levels in plots with high phylogenetic diversity, versus plants in plots with low phylogenetic diversity. Herbivore damage was higher in plots with low phylogenetic diversity, where pioneer plants produced less defenses. Finally, predator activity on clay models was greater in plants within the low phylogenetic diversity treatment, but only for non-myrmecophytic species. These results suggest that plant phylogenetic diversity can influence species resource allocation for growth and defenses, and further modify the interaction between plants, herbivores, and their natural enemies. Moreover, such effects likely depend on plant life history and the presence of mutualistic interaction with ants.
Targeting antimalarial metabolites from the actinomycetes associated with the Red Sea sponge Callyspongia siphonella using a metabolomic method
Authors: Gamaleldin Noha M. , Bahr Hebatallah S. , Millán-Aguiñaga Natalie , Danesh Mahshid , Othman Eman M. , Dandekar Thomas , Hassan Hossam M. , Ramadan Usama 
Published: April 2023

Abstract
Malaria is a persistent illness that is still a public health issue. On the other hand, marine organisms are considered a rich source of anti‑infective drugs and other medically significant compounds. Herein, we reported the isolation of the actinomycete associated with the Red Sea sponge Callyspongia siphonella. Using "one strain many compounds" (OSMAC) approach, a suitable strain was identified and then sub-cultured in three different media (M1, ISP2 and OLIGO). The extracts were evaluated for their in-vitroantimalarial activity against Plasmodium falciparum strain and subsequently analyzed by Liquid chromatography coupled with high-resolution mass spectrometry (LC-HR-MS). In addition, MetaboAnalyst 5.0 was used to statistically analyze the LC-MS data. Finally, Molecular docking was carried out for the dereplicated metabolites against lysyl-tRNA synthetase (PfKRS1). The phylogenetic study of the 16S rRNA sequence of the actinomycete isolate revealed its affiliation to Streptomycesgenus. Antimalarial screening revealed that ISP2 media is the most active against Plasmodium falciparum strain. Based on LC-HRMS-based metabolomics and multivariate analyses, ISP2-S and M1-S are the optimal media for metabolites production. OPLS-DA suggested that quinone derivatives are abundant in the extracts with the highest antimalarial activity. Fifteen important compounds were identified where 8 of these metabolites were correlated to the observed antimalarial activity of the active extracts. According to molecular docking experiments, saframycin Y3 and juglomycin E showed the greatest binding energy scores (-6.2 and -5.13) to lysyl-tRNA synthetase (PfKRS1), respectively. Using metabolomics and molecular docking investigation, the quinones, saframycin Y3 (5) and juglomycin E (1) were identified as promising antimalarial therapeutic candidates. Our approach can be used as a first evaluation stage in natural product drug development, facilitating the separation of chosen metabolites, particularly biologically active ones.
Gsk3β deficiency in macrophages alleviates the progression of nonalcoholic steatohepatitis by promoting PINK1-mediated mitophagic autophagy α β γ
Authors: zhang zihao , Li Jinyang , Kong Xiangyi , Sun Xiaohu , Deng Zhenhua , Tang Weiwei , Zhou Haoming , Ni Ming , Xia Yongxiang 
Published: April 2023

Abstract
Nonalcoholic fatty liver disease (NAFLD) is a chronic inflammation of liver cells
Based on hepatocyte steteaosis. Its process and pathogenesis are extremely complex,
Among them, oxidative stress and inflammation cause excessive production
Reactive oxygen species (ROS) are one of the reasons for the transition from NAFLD
To NASH and severe liver damage. Pink1-mediated mitophagy is selective
Mechanisms that control the production of mitochondrial reactive oxygen species
Species (ROS) by degrading damaged mitochondria. However, contribute
Pink1-mediated mitophagy in NAFLD and its regulatory mechanism are incomplete
Understand. Glycogen synthase kinase 3β is an evolutionarily conserved one
Serine/threonine kinase. Our study shows that p-GSK3β (Ser9) is expressed
Elevated in liver macrophages in NASH patients and diet-induced NASH mice. at
In addition, bone marrow Gsk3β deficiency and Gsk3β inhibitor (SB216763) therapy may be used
Effectively slow the progression of nonalcoholic steatohepatitis. In functional research,
In the body and in vitro high-fat environment, bone marrow Gsk3β deficiency promotes
PINK1 is expressed on mitochondria and activates parkin by phosphorylation
Ubiquitin protein, which further promotes the occurrence of mitochondrial autophagy and thus decreases
ROS production and activation of NLRP3 inflammasome in macrophages. at
Conclusion, our data confirm the presence of Gsk3β
NASH is developed by regulating Pink1-mediated mitophagy.
Inhibition of Gsk3β may be an effective therapeutic target for NASH.
On the fast track: The benefits of ESG performance on the commercial credit financing
Authors: Huang Yujie , Bai Fuping , Shang Mengting , Ahmad Mahmood 
Published: April 2023

Abstract

Under the strategy of sustainability, whether a company can increase its financing capacity by improving environmental, social, and governance (ESG) performance is vital to promoting its high-quality development. Based on China's A-share listed companies from 2009 to 2021, this study empirically examines the impact of corporate ESG performance on commercial credit financing (CCF). Following the research results, a company with better ESG performance is more likely to get CCF support from suppliers. Further analysis of the impact mechanisms shows that ESG performance can effectively reduce environmental, social, and governance risks by promoting green innovation, improving social reputation, and reducing operational risks, thereby improving the CCF of enterprises. Our work expands and enriches the theory of informal financing of enterprises, integrated with the more comprehensive assessment criteria for sustainable development.
Comprehensive Evaluation of Community Human Settlement Resilience and Spatial Characteristics Based on the Supply-demand Mismatch between Health Activities and Environment: A Case Study of Downtown Shanghai, China
Authors: Zhong Qikang , Chen Yue 
Published: April 2023

Abstract
Introduction Under the trends toward globalisation, human settlement has increasingly become a key risk factor influencing human life. The equal relationship between human beings and the environment is an important support to improve the resilience of human settlement environment, and the resilience of community human settlement environment is an important determinant to cope with the pressure of globalisation. Thus, focusing on the principal contradictions of community development under the pressure of globalisation, this study explores the connotation of community resilience oriented towards the supply-demand mismatch between community residents' health activities and environment, constructs an organically integrated theoretical framework and evaluation indicator system.
Methods This study takes downtown Shanghai as an example, relying on 2018 land use data, Dorray Sport APP data, geospatial data and urban statistics as data sources, adopting the AHP-entropy weight method and the square grid method; a comprehensive community human settlement resilience index (CRI) model based on the DPSIR model is built to quantitatively analyse the spatial and temporal distribution of community human settlement resilience (CR), and the coupling relation between driving factors and human settlement resilience is quantitatively analysed by using tools such as the geographical detector and Origin software.
Results i) the scores of CR showed a "slide-shaped" fluctuation difference situation; ii) the spatial pattern of CR showed a "pole-core agglomeration and radiation" type and a "ring-like agglomeration and radiation" type. iii) Distance to bus stops, average annual temperature, CO2 emissions, building density and number of jogging trajectories are the dominant factors affecting the resilience level of community human settlement.
Conclusion From the perspective of the supply-demand mismatch between health activities and environment, this paper attempts to offer a general reference for the compilation of similar human settlement evaluation systems in various countries, by sorting out the international experience in the compilation, analysis and calibration of relevant human settlement factor tables, putting forward a new approach for the study of healthy human settlement in communities, which provides references for the constellation of assessments of building healthy community and healthy city all over the world.