bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health, Health Care, and Equality of Opportunity: The Rationale for Universal Health Care
Authors: Wester Gry 
Published: January 2023

AbstractThis article discusses what arguments best support universal health care (UHC), with a focus on Norman Daniels’ equality of opportunity account. This justification for UHC hinges on the assumption of a close relationship between health care and health. But in light of empirical research that suggests that health outcomes are shaped to a large extent by factors other than health care, such as income, education, housing, and working conditions, the question arises to what extent health care is really necessary to protect and promote health, and thereby opportunity. The author argues that, although this challenge to the equality of opportunity rationale is legitimate, it is not sufficiently specified to allow us to adequately assess the extent to which universal health succeeds in protecting equality of opportunity. The article concludes by outlining a more promising strategy for developing a viable rationale for UHC.
Opportunistic Mental Health Screening: Is there a Role Following a Disaster? Lessons from the 2010-2011 Queensland (Australia) Floods and Cyclones
Authors: Crompton David , Kohleis Peter , Shakespeare-Finch Jane , FitzGerald Gerard , Young Ross 
Published: January 2023

AbstractBackground:Following the 2010-2011 floods and cyclones that affected 78% of Queensland, Australia, a State-wide mental health response was established. The response plan included a 24-hour access line. This study examines the effectiveness of the mental health screening program conducted via the State-wide health call center (13HEALTH) in 2012.Methods:Callers to the 13HEALTH line were screened to assess the impact of the disaster. The 13HEALTH clinicians administered the Primary Care-Posttraumatic Stress Disorder Scale (PC-PTSD) screening measure. Those scoring more than two on the PC-PTSD Scale were provided information on the emotional impact of disasters and a referral to the post-disaster specialist mental health program (SMHP). For calls related to those under 18, a single-item question assessed behavioral or emotional changes since the natural disasters. Those with identified changes were offered a referral to a post-disaster SMHP.The study evaluates the relationship between disaster exposure and the likelihood of 13HEALTH callers experiencing physical health concerns and unacknowledged mental health symptoms. The program’s cost for the 12 months of 2012 was assessed using data from the financial contract.Results:In 2012, there were 205,064 calls to 13HEALTH: 19,708 identified as residing in a flood or cyclone-affected area, 7,315 adults indicated they were personally affected, and 907 scored more than two on the PC-PTSD Scale. Only 700 agreed to a referral to the SMHP. There were 290 children under 18 assessed as at risk; 207 accepted a referral to a SMHP.Regions that experienced a greater impact from the floods and cyclones were 1.3-2.3 times more likely to report being personally affected by the floods and cyclones. Similarly, these regions had more callers scoring more than two on the PC-PTSD Scale. The total cost of the 13HEALTH program for 2012 was $53,284 (AU) across all age groups.Conclusion:The 13HEALTH general health post-disaster screening program demonstrates opportunistic screening may assist identification of those with unmet mental health needs. The data indicate an increased likelihood of personal exposure in the more affected regions with an increased risk of unrecognized psychological symptoms as assessed by the PC-PTSD Scale. However, more than 20% declined referral to a SMHP.
Relationship between dietary patterns and physical performance in the very old population: a cross-sectional study from the Kawasaki Aging and Wellbeing Project
Authors: Yu Tao , Oguma Yuko , Asakura Keiko , Abe Yukiko , Arai Yasumichi 
Published: January 2023

AbstractObjectives:As the world’s population is ageing, improving the physical performance (PP) of the older population is becoming important. Although diets are fundamental to maintaining and improving PP, few studies have addressed the role of these factors in adults aged ≥ 85 years, and none have been conducted in Asia. This study aimed to determine the dietary patterns (DP) and examine their relationship with PP in this population.Design:This cross-sectional study (Kawasaki Aging and Wellbeing Project) estimated food consumption using a brief-type self-administered diet history questionnaire. The results were adjusted for energy after aggregating into thirty-three groups, excluding possible over- or underestimation. Principal component analysis was used to identify DP, and outcomes included hand grip strength (HGS), timed up-and-go test, and usual walking speed.Setting:This study was set throughout several hospitals in Kawasaki city.Participants:In total, 1026 community-dwelling older adults (85–89 years) were enrolled.Results:Data of 1000 participants (median age: 86·9 years, men: 49·9 %) were included in the analysis. Three major DP (DP1: various foods, DP2: red meats and coffee, DP3: bread and processed meats) were identified. The results of multiple regression analysis showed that the trend of DP2 was negatively associated with HGS (B, 95 % CI –0·35, –0·64, –0·06).Conclusions:This study suggests a negative association between HGS and DP characterised by red meats and coffee in older adults aged ≥ 85 years in Japan.
Results from the Strong Families Start at Home/Familias Fuertes Comienzan en Casa: feasibility randomised control trial to improve the diet quality of low-income, predominantly Hispanic/Latinx children
Authors: Tovar Alison , Fox Katelyn , Gans Kim M , Markham Risica Patricia , Papandonatos George D , Ramirez Andrea , Gorin Amy A , von Ash Tayla , Jennings Ernestine , Bouchard Kelly , McCurdy Karen 
Published: January 2023

AbstractObjective:To describe the feasibility, acceptability and results of Strong Families Start at Home, a 6-month pilot trial of a home-based food parenting/nutrition intervention.Design:Pilot randomised controlled trial.Setting:Participants received six visits with a community health worker trained in motivational interviewing (three home visits, three phone calls); an in-home cooking or reading activity; personalised feedback on a recorded family meal or reading activity; text messages and tailored printed materials.Participants:Parents and their 2–5-year-old child were randomised into intervention (responsive food parenting practices/nutrition) or control (reading readiness) groups.Results:Parents (n 63) were mostly mothers (90 %), Hispanic/Latinx (87 %), born outside the USA (62 %), with household incomes <$25 k (54 %). Despite delivery during COVID-19, 63 % of dyads were retained at 6 months. The intervention was delivered with high fidelity. All parents in the intervention group (n 24) expressed high levels of satisfaction with the intervention, which produced positive treatment effects for whole and total fruit component Healthy Eating Index-2015 scores (point estimate (PE) = 2·14, 95 % CI (0·17, 1·48); PE = 1·71, 95 % CI (0·16, 1·47), respectively) and negative treatment effects for sodium (PE = -2·09, 95 % CI (−1·35, −0·04)). Positive treatment effects also resulted for the following food parenting practices: regular timing of meals and snacks (PE = 1·08, 95 % CI (0·61, 2·00)), reducing distractions during mealtimes (PE = -0·79, 95 % CI (−1·52, −0·19)), using food as a reward (PE = -0·54, 95 % CI (−1·35, −0·04)) and providing a supportive meal environment (PE = 0·73, 95 % CI (0·18, 1·51)).Conclusion:Given the continued disparities in diet quality among low-income and diverse families, continued efforts to improve child diet quality in fully powered intervention trials are needed.
Food insecurity and coping strategies and their association with anxiety and depression: a nationally representative South African survey
Authors: Dlamini Siphiwe N , Craig Ashleigh , Mtintsilana Asanda , Mapanga Witness , Du Toit Justin , Ware Lisa J , Norris Shane A 
Published: January 2023

AbstractObjective:To investigate food insecurity and related coping strategies among South African households and their associations with anxiety and depression.Design:Cross-sectional study. Food insecurity and coping strategies were assessed using a modified Community Childhood Hunger Identification Project and the Coping Strategies Index questionnaires. The Generalized Anxiety Disorder-7 and Patient Health Questionnaire-9 were used to assess anxiety and depression risk. Ordered logistic regressions were used to test associations of food insecurity and related coping strategies with anxiety and depression.Setting:South Africa during COVID-19, October 2021.Participants:Nationally representative sample of 3402 adults, weighted to 39,640,674 South African households.Results:About 20·4 % of South African households were food insecure, with the most affected being from the lowest socio-economic groups. Shifting from ‘food secure’ to ‘at risk’ or from ‘at risk’ to ‘food insecure’ group was associated with 1·7 times greater odds of being in a higher category of anxiety or depression (P < 0·001). All coping strategies were used to some extent in South African households, with 46·0 % relying on less preferred and less expensive foods and 20·9 % sending a household member to beg for food. These coping strategies were mostly used by food-insecure households. Although the odds of moving to a higher category of anxiety and depression were observed among all coping strategies (all P < 0·001), begging for food was associated with the highest odds (OR = 2·3).Conclusions:Food insecurity remains a major health threat in South Africa. Public measures to address mental health should consider reductions in food insecurity as part of their strategy.
Design and validation of a novel online platform to support the usability evaluation of wearable robotic devices
Authors: Meyer Jan T. , Tanczak Natalie , Kanzler Christoph M. , Pelletier Colin , Gassert Roger , Lambercy Olivier 
Published: January 2023

Abstract
Wearable robotic devices (WRD) are still struggling to fulfill their vast potential. Inadequate daily life usability is one of the main hindrances to increased technology acceptance. Improving usability evaluation practices during the development of WRD could help address these limitations. In this work, we present the design and validation of a novel online platform aiming to fill this gap, the Interactive Usability Toolbox (IUT). This platform consists of a public website that offers an interactive, context-specific search within a database of 154 user research methods and educational information about usability. In a dedicated study, the effect of this platform to support usability evaluation was investigated. Twelve WRD experts were asked to complete the task of defining usability evaluation protocols for two specific use cases. The platform was provided to support one of the use cases. The quality and composition of the proposed protocols were assessed by (i) two blinded reviewers, (ii) the participants themselves, and (iii) the study coordinators. We showed that using the IUT significantly affected the proposed evaluation focus, shifting protocols from mainly effectiveness-oriented to more user-focused studies. The protocol quality, as rated by the external reviewers, remained equivalent to those designed with conventional strategies. A mixed-method usability evaluation of the platform yielded an overall positive image, with detailed suggestions for further improvements. The IUT is expected to positively affect the evaluation and development of WRD through its educational value, the context-specific recommendations supporting ongoing benchmarking endeavors, and highlighting the value of qualitative user research.
A Revised Estimate of Early Pliocene Global Mean Sea Level Using Geodynamic Models of the Patagonian Slab Window
Authors: Hollyday Andrew , Austermann Jacqueline , Lloyd Andrew , Hoggard Mark , Richards Fred , Rovere Alessio 
Published: January 2023

AbstractPaleoshorelines serve as measures of ancient sea level and ice volume but are affected by solid Earth deformation including processes such as glacial isostatic adjustment (GIA) and mantle dynamic topography (DT). The early Pliocene Epoch is an important target for sea‐level reconstructions as it contains information about the stability of ice sheets during a climate warmer than today. Along the southeastern passive margin of Argentina, three paleoshorelines date to early Pliocene times (4.8–5.5 Ma), and their variable present‐day elevations (36–180 m) reflect a unique topographic deformation signature. We use a mantle convection model to back‐advect present‐day buoyancy variations, including those that correspond to the Patagonian slab window. Varying the viscosity and initial tomography‐derived mantle buoyancy structures allows us to compute a suite of predictions of DT change that, when compared to GIA‐corrected shoreline elevations, makes it possible to identify both the most likely convection parameters and the most likely DT change. Our simulations illuminate an interplay of upwelling asthenosphere through the Patagonian slab window and coincident downwelling of the subducted Nazca slab in the mantle transition zone. This flow leads to differential upwarping of the southern Patagonian foreland since early Pliocene times, in line with the observations. Using our most likely DT change leads to an estimate of global mean sea level of 17.5 ± 6.4 m (1σ) in the early Pliocene Epoch. This confirms that sea level was significantly higher than present and can be used to calibrate ice sheet models.
Seasonal Diversity of El Niño‐Induced Marine Heatwave Increases in the Bay of Bengal
Authors: Lin Xinyu , Qiu Yun , Wang Jianjun , Teng Hui , Ni Xutao , Liang Kunming 
Published: January 2023

AbstractThis study explored the characteristics of marine heatwaves (MHWs) and the related dynamics in Bay of Bengal (BOB) associated with El Niño events during 1982–2020. This showed that El Niño can induce more MHW days, which displays remarkable seasonality. The strong influences of El Niño were found in the southern BOB at its peak phase in winter and the following spring, characterized by an increase in MHW days by 106% in winter and 83% in spring. In the proceeding summer, its influences weakened and shifted to the central bay. The more MHW days during winter and spring are primarily caused by the enhanced solar radiation associated with El Niño and partly contributed by the thick barrier layer in winter. In contrast, besides atmospheric heating, the deepening thermocline in the central bay induced by equatorial and local winds also plays an important role in the increase in MHWs during summer.
Wintertime Supraglacial Lake Drainage Cascade Triggers Large‐Scale Ice Flow Response in Greenland
Authors: Maier Nathan , Andersen Jonas Kvist , Mouginot Jérémie , Gimbert Florent , Gagliardini Olivier 
Published: January 2023

AbstractSurface melt forces summertime ice‐flow accelerations on glaciers and ice sheets. Here, we show that large meltwater‐forced accelerations also occur during wintertime in Greenland. We document supraglacial lakes (SGLs) draining in cascades at unusually high elevation, causing an expansive flow acceleration over a ∼5,200 km2 region during winter. The three‐component interferometric surface velocity field and decomposition modeling reveal the underlying flood propagation with unprecedented detail as it traveled over 160 km from the drainage site to the margin, providing novel constraints on subglacial water pathways, drainage morphology, and links with basal sliding. The triggering SGLs continuously grew over 40 years and suddenly released decades of stored meltwater, demonstrating surface melting can impact dynamics well beyond melt production. We show these events are likely common and thus their cumulative impact on dynamics should be further evaluated.
Ionospheric Pre‐Sunrise Uplift: Comparison of Sanya Incoherent Scatter Radar Observations and Numerical Simulations
Authors: Yue Xinan , Cai Yihui , Wang Junyi , Lei Jiuhou , Wang Zhongqiu , Wang Yonghui , Li Mingyuan , Zhang Ning , Ding Feng , Ning Baiqi 
Published: January 2023

AbstractUsing the high spatial‐temporal resolution electron density profiles observed by the newly built Sanya Incoherent Scatter Radar at Sanya (18.3°N, 109.6°E) in its first 1‐month‐long continuous run with Barker code, we identified a substantial ionospheric pre‐sunrise uplift at low latitudes associated with the upward movement of ions. The uplift mainly occurs during local solar time 01:00–06:00 and is ∼52–240 km with significant night‐to‐night variability. With increasing geomagnetic and/or interplanetary activity, the uplift can have a larger amplitude. Further TIEGCM simulations show that the pre‐sunrise ionospheric uplift is jointly determined by the net effect of ambipolar diffusion, neutral wind, and E × B drift. The neutral wind during 00:00–05:00 usually lifts the ionosphere through equatorward wind. After 02:00, the weakening and/or even the reversal of downward E × B drift, which is not sufficient to offset the net uplift effect of wind and diffusion combination, triggers uplifting.
Stochastic Watershed Model Ensembles for Long‐Range Planning: Verification and Validation
Authors: Shabestanipour Ghazal , Brodeur Zachary , Farmer William H. , Steinschneider Scott , Vogel Richard M. , Lamontagne Jonathan R. 
Published: January 2023

AbstractDeterministic watershed models (DWMs) are used in nearly all hydrologic planning, design, and management activities, yet they cannot generate streamflow ensembles needed for hydrologic risk management (HRM). The stochastic component of DWMs is often ignored in practice, leading to a systematic bias in extreme events. Since traditional stochastic streamflow models used in HRM struggle to account for anthropogenic change, there is a need to convert DWMs into stochastic watershed models (SWMs) to generate ensembles for use in HRM. A DWM can be converted to an SWM using a post‐processing (pp) approach to add error to the DWM predictions. Many pp methods advanced in the area of flood forecasting are useful in HRM and for correcting extreme event biases. Selecting a suitable error model for pp is challenging due to nonnormality, skewness, heteroscedasticity, and autocorrelation. We develop a parsimonious pp method based on an autoregressive (AR) model of the logarithm of the ratio of the observations and simulations, which leads to AR model residuals that are approximately symmetric and independent. We document the value of pp for improving flood and low flow frequency analysis and we reintroduce the concepts of verification and validation of stochastic streamflow ensembles to ensure that the SWM can reproduce both statistics it was and was not designed to reproduce, respectively. These concepts are illustrated on a Massachusetts basin using the USGS Precipitation Runoff Modeling System, with an additional analysis indicating the approach may be applicable to 1,225 other sites across the United States.
Research progress of large size SiC single crystal materials and devices
Authors: Chen Xiufang , Yang Xianglong , Xie Xuejian , Peng Yan , Xiao Longfei , Shao Chen , Li Huadong , Hu Xiaobo , Xu Xiangang 
Published: January 2023

AbstractSiC semiconductor is the focus of recent international research. It is also an important raw material for China to achieve carbon emission peak and carbon neutrality. After nearly 20 years of research and development, we focus on the three types SiC crystals, n-type, p-type and semi-insulating, indicating the development of Shandong University for crystal growth. And defects control, electrical property, atomic polishing, and corresponding device authentication all obtain great progress. Total dislocation density of 6-inch n-type substrates decreases to 2307 cm−2, where BPD (Basal Plane Dislocation) lowers to 333 cm−2 and TSD (Threading Screw Dislocation) 19 cm−2. The full width at half maximum (FWHM) (0004) rocking curves is only 14.4 arcsec. The resistivity reaches more than 1E + 12 Ω·cm for semi-insulating SiC and lower than 20 mΩ·cm for n-type SiC. The impurity concentrations in 6-inch high-purity semi-insulating (HPSI) SiC crystals reach extreme low levels. The devices made of various substrate materials have good performance.
Polygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort
Authors: Duncan Laramie , Shen Hanyang , Schulmann Anton , Li Tayden , Kolachana Bhaskar , Mandal Ajeet , Feng Ningping , Auluck Pavan , Marenco Stefano 
Published: January 2023

AbstractA new era of human postmortem tissue research has emerged thanks to the development of ‘omics technologies that measure genes, proteins, and spatial parameters in unprecedented detail. Also newly possible is the ability to construct polygenic scores, individual-level metrics of genetic risk (also known as polygenic risk scores/PRS), based on genome-wide association studies, GWAS. Here, we report on clinical, educational, and brain gene expression correlates of polygenic scores in ancestrally diverse samples from the Human Brain Collection Core (HBCC). Genotypes from 1418 donors were subjected to quality control filters, imputed, and used to construct polygenic scores. Polygenic scores for schizophrenia predicted schizophrenia status in donors of European ancestry (p = 4.7 × 10−8, 17.2%) and in donors with African ancestry (p = 1.6 × 10−5, 10.4% of phenotypic variance explained). This pattern of higher variance explained among European ancestry samples was also observed for other psychiatric disorders (depression, bipolar disorder, substance use disorders, anxiety disorders) and for height, body mass index, and years of education. For a subset of 223 samples, gene expression from dorsolateral prefrontal cortex (DLPFC) was available through the CommonMind Consortium. In this subgroup, schizophrenia polygenic scores also predicted an aggregate gene expression score for schizophrenia (European ancestry: p = 0.0032, African ancestry: p = 0.15). Overall, polygenic scores performed as expected in ancestrally diverse samples, given historical biases toward use of European ancestry samples and variable predictive power of polygenic scores across phenotypes. The transcriptomic results reported here suggest that inherited schizophrenia genetic risk influences gene expression, even in adulthood. For future research, these and additional polygenic scores are being made available for analyses, and for selecting samples, using postmortem tissue from the Human Brain Collection Core.
HLTF promotes hepatocellular carcinoma progression by enhancing SRSF1 stability and activating ERK/MAPK pathway
Authors: Xu Yanan , Ke Shanjia , Lu Shounan , Wang Chaoqun , Li Zihao , Feng Zhigang , Yu Hongjun , Bai Miaoyu , Qian Baolin , Yin Bing , Li Xinglong , Hua Yongliang , Jiang Hongchi , Ma Yong 
Published: January 2023

AbstractHelicase-like transcription factor (HLTF) has been found to be involved in the progression of several tumors, but the role of HLTF in hepatocellular carcinoma (HCC) progression has not been studied. Here, our study explored the underlying mechanism of HLTF in HCC progression for the first time. Database analysis and clinical sample examination indicated that HLTF was upregulated in HCC tissues and was related to poor clinicopathological features in patients. Upregulation of HLTF accelerated the growth and metastasis of HCC cells both in vitro and in vivo. Bioinformatics analysis and subsequent experiments revealed that ERK/MAPK signaling pathway activation was vital to HLTF-mediated proliferation and metastasis in HCC cells. Moreover, HLTF was demonstrated to interact with SRSF1 and contribute to its protein stability to activate the ERK/MAPK signaling pathway and enhance HCC growth and metastasis. In addition, miR-511-5p was expressed at a low level in HCC tissues, was negatively correlated HLTF, and regulated HLTF expression. Our study shows that HLTF plays an oncogenic role in HCC progression and provides a novel biomarker and therapeutic target for the diagnosis and treatment of HCC.