bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of Salivary Cytokine Il-17a and 1,25 Dihydroxycholecalciferol in Patients Undergoing Orthodontic Treatment
Authors: Sagar Sandra , Ramani Pratibha , Moses Sagar , S Gheena , Jayaraman Selvaraj 
Published: June 2023

Abstract

BACKGROUND
The management of malocclusion has developed greatly in terms of treatment simulation and biomechanics, but treatment duration has been a great concern to the clinician as well as the patient. Vitamin D stimulates both osteoclasts and osteoblasts and was found to be the most significant in Orthodontic Tooth Movement acceleration. Inflammatory cytokines like IL-17A also play an important role in osteoclastogenesis and enhances the rate of Orthodontic Tooth Movement.
AIM
To perform a simultaneous evaluation of pro inflammatory salivary cytokine IL-17A and salivary vitamin D3 and to correlate their role on orthodontic tooth movement.
MATERIALS AND METHODS
A prospective cohort study was conducted among n = 97 patients . Saliva samples were collected from the patients at three phases of the orthodontic treatment, centrifuged and stored at 4℃ for evaluation of salivary Vitamin D3 levels and Pro-inflammatory cytokine IL-17A using ELISA.
RESULTS
The mean salivary VitaminD3 levels were 41.250ng/ml, 33.246 ng/ml and 35.043ng/ml during the initial phase, lag phase and log phase of orthodontic treatment.
The mean pro-inflammatory cytokine IL-17 A levels were 107.79 pg/ml , 102.98pg/ml and 66.156 pg/ml during the initial phase, lag phase and log phase of orthodontic treatment.
There was a correlation between salivary vitamin D3 level and salivary cytokine IL-17A levels during the various phases of orthodontic treatment using Spearman’s correlation rho test and linear regression analysis. There was no significant difference(p>0.05) between vitamin D3 levels and gender during the various phases( initial phase, lag phase and log phase)of orthodontic treatment.
CONCLUSION
Vitamin D3 and pro-inflammatory cytokine IL-17A was found to have a definite role in the osteoblastic and osteoclastic activity. Thus, the Vitamin D3 levels have been quantified during the various phases of orthodontic treatment and this can be used clinically for the supplementation of Vitamin D in patients with low vitamin D levels and can enhance the treatment duration for the patient with less damaging effects to the surrounding tissues.
The framing of depression in the South African print media over a 13-year period (2004-2016): a retrospective study.
Authors: Thobela Zanele , Nyamaruze Patrick , Akintola Olagoke 
Published: June 2023

Abstract

Background
Depression is the leading cause of mental health-related disease burden globally, yet the symptoms of the disorder are not well-understood and it is stigmatised in South Africa. The way depression is portrayed in the media contributes to an understanding of the symptoms, causes, and treatment of the condition. While research on the framing of depression has been conducted widely in other contexts, our search did not yield any study on media framing of depression in South Africa. Therefore, this study used the framing theory to examine the media framing of depression following the enactment of two mental health policies in South Africa.
Methods
We examined 152 news stories that covered depression from 21 South African newspapers retrieved from the SABINET – SA Media online archive over a 13-year period (2004–2016). We used the four categories of framing; problems, causes, moral judgements and remedies to conduct deductive and inductive thematic analysis.
Results
The findings show that most of the news stories had problems as their main frame. The problems identified included the challenge of diagnosing and treating depression, misconceptions about depression, lack of funding for mental health initiatives and shortage of mental health practitioners. Most news stories framed depression as mainly caused by various risk factors, including high rates of crime and violence. Calls were made for increased mental health funding. Improving knowledge of depression in the community and seeking mental health services and support were identified as remedies.
Conclusions
This study provides an understanding of the framing of issues related to depression in the news media post the enactment of two Mental Health policies. While the two policies have clear provisions that seek to ensure that appropriate care, treatment and rehabilitation are provided to people living with mental health conditions, numerous challenges exist in the health system and society. To overcome these challenges, the study suggests a need for multi-level interventions that target to increase funding, reduce mental health stigma, and develop tailor made mental health promotion and prevention strategies.
Solutions to improve the quality of higher education services in crisis situations using soft systems methodology (Case study: Shahid Beheshti University)
Authors: ramezani sajad , jokarmoshtani mohamadreza , talebi davood , Dorri Behrouz 
Published: June 2023

Abstract
The education sector encountered serious problems and the quality improvement of higher education services stopped after the Covid-19 pandemic. After the peak period of this virus, it is required to predict the crisis and consider appropriate solutions to improve the quality of higher education services. Thus, this study aimed to provide some solutions to improve the quality of higher education services in crisis situations.This study was applied in terms of objective and mixed in terms of approach. Interviews and questionnaires were used in this study for data collection. The combination of soft systems methodology with hesitant fuzzy best-worst method (HFBWM) was used to encounter the research problem. Based on soft systems methodology, three general areas were presented to improve the quality of higher education services. Such areas included the solutions related to support services, solutions related to social development and team spirit, and improvement solutions related to management and planning. Thus, several solutions were provided in each area for Shahid Beheshti University. Finally, the solutions were prioritized based on the HFBWM. The establishment of updated educational systems, implementation of a strategic operational plan to improve services, and scientific consensus to improve education were considered as the prioritized solutions to improve the quality of higher education services in crisis situations at Shahid Beheshti University.
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) with cisplatin and doxorubicin in combination with FOLFOX chemotherapy as a first-line treatment for gastric cancer patients with peritoneal metastases: single-arm phase II study
Authors: Luksta Martynas , Bausys Augustinas , Bickaite Klaudija , Rackauskas Rokas , Paskonis Marius , Luksaite-Lukste Raminta , Ranceva Anastasija , Stulpinas Rokas , Brasiuniene Birute , Baltruskeviciene Edita , Lachej Nadezda , Sabaliauskaite Rasa , Bausys Rimantas , Tulyte Skaiste , Strupas Kestutis 
Published: June 2023

Abstract
Background
Gastric cancer (GC) remains among the most common and most lethal cancers worldwide. Peritoneum is the most common site for distant dissemination. Standard treatment for GC peritoneal metastases (PM) is a systemic therapy, but treatment outcomes remain very poor, with median overall survival ranging between 3–9 months. Thus, novel treatment methods are necessary. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is the most novel technique for intraperitoneal chemotherapy. Some preliminary data suggest PIPAC can achieve improved long-term outcomes in patients with GC PM, especially when used in combination with system chemotherapy. However, there is a lack of data from well-design prospective studies that would confirm the efficacy of PIPAC and systemic therapy combination for first-line treatment.
Methods
This study is an investigator-initiated single-arm, phase II trial to investigate the efficacy of PIPAC combined with systemic FOLFOX (5-fluorouracil, oxaliplatin, leucovorin) as a first-line treatment for GC PM. The study is conducted in 2 specialized GC treatment centers in Lithuania. It enrolls GC patients with histologically confirmed PM without prior treatment. The treatment protocol consists of PIPAC with cisplatin (10.5 mg/m2 body surface in 150 mL NaCl 0.9%) and doxorubicin (2.1 mg/m2 in 50 mL NaCl 0.9%) followed by 2 cycles of FOLFOX every 6–7 weeks. In total 3 PIPACs and 6 cycles of FOLFOX will be utilized. The primary outcome of the study is the objective response rate (ORR) according to RECIST v. 1.1 criteria [20] in a CT scan performed 7 days after the 4th cycle of FOLFOX. Secondary outcomes include ORR after all experimental treatment, PIPAC characteristics, postoperative morbidity, histological and biochemical response, ascites volume, quality of life, overall survival, and toxicity.
Discussion
This study aims to assess PIPAC and FOLFOX combination efficacy for previously untreated GC patients with PM.
Trial registration
NCT05644249. Registered on December 9, 2022.
Radical Intermediates and Stable Products in Acrolein Pyrolysis
Authors: Muzika Michael , Genossar-Dan Nadav , Fux Dana , Lavan Shani Har , Zamir Uri , Rozenberg Illya , Hemberger Patrick , Baraban Joshua H. 
Published: June 2023

Abstract
Acrolein is a commonly encountered health hazard and pollutant. It is frequently used in industrial synthesis and is also a by-product of many combustion and other high temperature processes, especially those involving biological substances (e.g. forest fires, deep frying, or cigarette smoke). Despite the clear need for investigation of the chemical behavior of acrolein at high temperatures, little experimental work has been done on the decomposition of acrolein using apparatus capable of observing reactive species.
In this work, the pyrolysis of acrolein was studied at temperatures of up to 1700 K, with a focus on identification of radicals and other unstable species produced in the early reaction stages. Vinyl, formyl, and methyl radicals were all observed, either directly or indirectly. Detection of these reactive intermediates reveals the reaction pathways to stable species, including CO, ethylene, and acetylene, which were also observed. Our findings further the understanding of acrolein's high temperature chemistry, which has significant health and environmental importance.
Variations in nurse involvement in end-of-life practices in intensive care units worldwide (ETHICUS-2): a prospective observational study.
Authors: Benbenishty Julie Sarah , Ganz Freda DeKeyser , Lautrette Alexandre , Jaschinski Ulrich , Aggarwal Avneep , Soreide Eldar , Weiss Manfred , Dybwik Knut , Çizmeci Elif Ayşe , Ackerman Roberto Carlos Miranda , Estebanez-Montiel Belén , Ricou Bara , Robertsen Annette , Sprung Charles Lester , Avidan Alexander 
Published: June 2023

Abstract
Purpose
explore global ICU nurse involvement in end of life decisions, ETHICUS-2 prospective multinational, observational study was performed.
Methods
This is a secondary analysis of data obtained from the ETHICUS-2 study. Patients were followed until ICU discharge, death, or 2 months from the first decision to limit life-prolonging therapies. Data were collected by an ICU clinician recording end of life decisions typically at the time of first limitation. Nursing related questions included: were withholding or withdrawing treatment discussed with nurses? Who initiated the end of life discussion? Was a nurse involved in making the end of life decision? Was there agreement between physicians and nurses. Global regions were compared related to these four questions.
Results
A significant difference was found between regions, (p< .001) with Northern Europe and Australia/New Zealand having the most discussion with nurses and Latin America, Africa, Asia and North America the least. The percentages of nurses who were involved end of life decision ranging between 3-44%, the differences were statistically significant. Agreement between physicians and nurses related to decisions resulted in wide range of responses (27-86%) (p < .001). The percentages of EOL decisions in which agreement between physicians and nurses was not applicable included a wide range of responses from 0-41%
Conclusion
A large variability in nurse involvement in end of life care in the ICU was found. Perhaps due to perception of physicians and nurses view of themselves. Varying levels of expertise and experience of clinicians.
Between the lines: mitochondrial lineages in the heavily managed red deer population of Belarus
Authors: Valnisty Arseni Andreyevich , Homel Kanstantsin V , Kheidorova Ekaterina E , Molchan Vladislav O , Nikiforov Mikhail Y 
Published: June 2023

Abstract
Here we report the first thorough genetic characterization of the long understudied red deer population of Belarus in regards to its ancestry according to mtDNA sequence analysis. Employing a 328 base pair segment of the mitochondrial control region (d-loop) from 30 deer specimens of either sex recently harvested across the country, we have discovered 6 haplotypes belonging to 2 of the widely described European red deer lineages, or haplogroups: Iberian (A) and Maraloid (E), clarifying the range limits of both lineages in the region. Combining this data with a comparative analysis of genetic diversity and historical records, we conclude that the Belarusian population of red deer has an artificially mixed origin, though it remains unclear how desirable such a state of the local population is, in terms of sustainable management, use and conservation. Inquiries into ancient DNA are required in order to recognize the lineages closest to the now lost autochthonous population of Belarus.
Development of Vinyl-substituted Silica Based Coatings to Improve the Thermal Insulative Properties of Glass Surfaces
Authors: Koç Fatoş , Çok Selay Sert , Devrim Bora , Aksoy Sertan , Bilgin Gamze , Gizli Nilay 
Published: June 2023

Abstract
Thermal insulation of glass surfaces is essential in many respects because the glazing systems are the materials that lose the most energy in buildings or household devices. Therefore, application of coatings with low thermal conductivity is considered a key step in establishing the energy-efficient systems. In this study, vinyl substituted silica aerogel coatings were developed by the simple sol-gel method and applied on the glass substrates as in the bilayer form. Coating layers were composed of hydrophilic primary layer and hydrophobic top layer, which provides thermal insulation properties and acts as a protective layer barrier against water at the same time. The first layer consisted of SiO2 nanoparticles particles along with silica precursor of TEOS, while, the second layer was prepared with tetraethyl orthosilicate (TEOS) and vinyltrimethoxysilane (VTMS), which provided surface properties. The surface modification was applied with trimethylsilyl chloride (TMCS) to enhance the hydrophobic properties of surfaces. The aerogel-coated glasses were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Contact Angle (CA), and Thermal Conductivity Measurement. The thermal conductivity coefficient and water contact angle values were obtained as 0.126 W/mK and 88°. The experimental results showed that 85% decrease in thermal conductivity of glass substrate (from 0.8 to 0.126 W/mK) was obtained by applying bilayer silica aerogel coating.
Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation of tumor suppressor miRNAs
Authors: Pace Angelica , Scirocchi Fabio , Napoletano Chiara , Zizzari Ilaria Grazia , Po Agnese , Megiorni Francesca , Asquino Angela , Pontecorvi Paola , Rahimi Hassan , Marchese Cinzia , Ferretti Elisabetta , Nuti Marianna , Rughetti Aurelia 
Published: June 2023

Abstract
Background: Fibroblast growth factor receptor (FGFR) gene family alterations are found in several cancers, indicating their importance as potential therapeutic targets. The FGFR-tyrosine kinase inhibitor (TKI) pemigatinib (Pemazyre®, INCB054828) has been introduced in the treatment plan for advanced cholangiocarcinoma and more recently for relapsed or refractory myeloid/lymphoid neoplasms with FGFR2 and FGFR1 rearrangements, respectively. Several clinical trials are currently investigating the possible combination of pemigatinib with immunotherapy to synergistically amplify the anti-tumor activity.
Methods: NCI-H1581 lung cancer, KATO III gastric cancer and RT-112 bladder cancer cell lines were employed and FGFRs expression was evaluated by qRT-PCR and Western blot. Cell lines were treated with the FGFR1-3 inhibitor pemigatinib and then characterized for cell proliferation, apoptosis, production of intracellular reactive oxygen species (ROS), induction of senescence. Following pemigatinib treatment, the expression of microRNAs with tumor suppressor functions was analysed by qRT-PCR, while modulation of the proteins coded by their target genes was evaluated by Western blot.
Results: Pemigatinib reduced the proliferative ability of all cancer cells, inducing G1 phase cell cycle arrest and strong intracellular stress resulting in ROS production, senescence and apoptosis. Pemigatinib treatment also caused the upregulation of microRNAs (miR-133b, miR-139, miR-186, miR-195) with tumor suppressor functions in the cancer models investigated, along with the downregulation of validated protein targets with oncogenic roles (c-Myc, c-Met, CDK6, EGFR), suggesting that pemigatinib antitumor activity is at least in part mediated by microRNA modulation. Descriptive statistics was used to analyze the various data and student’s t test to compare the analysis of two groups.
Conclusions: These results contribute to clarifying the biological effects and molecular mechanisms mediated by the anti-FGFR TKI pemigatinib in distinct tumor settings and support its exploitation for combined therapies.
Superovulation with an anti-inhibin monoclonal antibody improves the reproductive performance of rat strains by increasing the pregnancy rate and the litter size
Authors: Mochida Keiji , Morita Kohtaro , Sasaoka Yoshio , Morita Kento , Endo Hitoshi , Hasegawa Ayumi , Asano Masahide , Ogura Atsuo 
Published: June 2023

Abstract

The rat is a multiparous rodent that has long been used in biomedical research, but the low reproductive performance in some rat strains hampers their broader use as research models. This study examined whether superovulation using an anti-inhibin monoclonal antibody (AIMA) could increase the litter size following natural mating in rats. In outbred Wistar rats, AIMA administration increased the number of ovulated oocytes by 1.3-fold. Importantly, AIMA did not affect fertilization and subsequent embryonic development, resulting in a 1.4-fold increase in litter size with a high pregnancy rate (89%). In contrast, conventional superovulation by equine/ human chorionic gonadotrophin administrations decreased the pregnancy rate to 6% and failed to increase the litter size. In inbred Brown Norway rats, AIMA increased the litter size 1.2-fold, and the pregnancy rate increased more than twice (86% vs. 38% in controls). AIMA also increased the litter size 2.0- and 1.5-fold in inbred Fischer 344 and Tokai High Avoider rats, respectively. Overall, when considering the pregnancy rate, AIMA increased the efficiency of offspring production 1.4-, 2.7-, 1.8-, and 1.5-fold in four rat strains. Thus, AIMA may consistently improve the reproductive performance by natural mating in rats, readily enabling their efficient use in biomedical research.
Resettlement Action Plan of Lagos Red Rail Line and Project Affected Persons’ (Paps) Perception
Authors: Atobatele Abolaji , Moliki Ahmed , Deinde-Adedeji Oluwatimilehin , Dele-Dada Moyosoluwa 
Published: June 2023

Abstract
This study emphasizes on the project affected persons and their perception concerning the activities of government in Lagos State. Lagos Red Rail Line is going to be a laudable project that will result in socio-economic development of the State and reduce traffic jam when completed. The study employed survey research technique which include administration of interview to the respondents through focus group discussion in Ikeja, Yaba, Mushin and Oyingbo and secondary source of data such as Journals, Internet, Government Gazette, and Magazines. The study reveals that lack of confidence in government coupled with high rate of illiteracy is responsible to the negative reaction of the project affected persons. The study therefore recommends that government at all levels in Lagos State and Nigeria at large should build the confidence of the residents in the State and Nigeria by fulfilling the promises made to residents of Lagos State and Nigerians before and after the elections.
Will AI Art Devalue Human Creativity?
Authors: Horton C. Blaine , White Michael W. , Iyengar Sheena S. 
Published: June 2023

Abstract
The contemporary art world is conservatively estimated to be a $65 billion USD market that employs millions of human artists, sellers, and collectors across the world. Yet recent attention paid to AI-made art in prestigious galleries, museums, and popular media has provoked debate around how these statistics will change. Unanswered questions fuel growing anxieties. Are AI-made and human-made art evaluated in the same ways? How will growing exposure to AI-made art impact evaluations of human creativity? Our research uses a psychological lens to explore these questions in the realm of visual art. We find that people devalue AI-made art across a variety of dimensions, even when they report it is indistinguishable from human-made art, and even when they believe it was produced collaboratively with a human. But we also find that comparing human and AI-made art increases perceptions of human creativity, an effect that can be leveraged to increase the value of human effort. Our results are robust across six experiments (N = 2,965) using a range of artistic stimuli and incorporating representative samples of the US population. Finally, we highlight conditions under which effects can be strengthened or weakened as well as dimensions where AI-devaluation effects are stronger.
A new technology combined robotics and 3D printing facilitates closed reduction of tibia shaft fractures using a minimally invasive plate as a reduction template: A technical note.
Authors: Liang Jinghao , Yang Hongju , Liu Dapeng 
Published: June 2023

Abstract
Less invasive fixation techniques are the mainstay in the treatment of tibial shaft fractures (TSFs), Intramedullary nailing (IMN) and minimally invasive plate osteosynthesis (MIPPO) are the least invasive and the preferred choices used nowadays. However, malreduction and radiation exposure are the main deficiencies associated with less invasive fixation techniques, especially rotation around the shaft axis is difficult to assess intra-operatively. Our focus is on describing a novel technology that integrates robotics and 3D printing to facilitate closed reduction of Tibial shaft fractures using minimally invasive plates as reduction templates. Using this technique, we have achieved anatomic reduction on phantom bone.