bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID and a Traditional Market
Authors: arsyad muhammad , Kadir Yahya , Basir Muhammad 
Published: December 2022

Abstract
Background: There is a sharp difference between traditional markets (souk/suq/souq/suːk) in Egypt and Indonesia, namely in terms of substance where traditional markets in Egypt are not just a place to shop for basic necessities but Egypt presents an artful traditional market tourism aspect while in Indonesia still uses traditional markets as a place to buy all kinds of basic household needs that are hustle and bustle, seem dirty and not organized, not neat, not organized, no art. This means that Egyptian civilization is very advanced and created a new culture long ago, while Indonesia is still using the old culture. Rationally, Egypt is safer than traditional markets in terms of health, social and culture. The study was conducted at Daya-Makassar, where the stigma associated with traditional markets is typically brought on by the comparable behavior of buyers and sellers as well as the first appearance of the coronavirus, namely at the wet market in Wuhan, China, in 2019. a novel line of research known as "from market to market." preliminary observations study carried out in the shutdown season in April 2020. Rigid health regulations that eventually signal relaxations.
Methods: The objective of this research is to provide answers to the following questions: what COVID is, how would they actually comprehend COVID, and how would they like to interact with other dealers and purchasers. This project is an example of exploratory research, and it will use five informants to collect data between March 2020 and November 2022. Techniques for gathering data, such as in-depth interviews, in-person enquiries, and more casual daily dialogue. By asking why and how traders in the traditional market forward COVID in Daya-Makassar operate, this study used qualitative approaches to evaluate data using domain analysis, taxonomies analysis, and component analysis.
Results: One of the sources claimed that the family's financial situation would be at risk and abandoned if COVID were given priority. It is focused on the situations of lower class citizens and has grown to be a significant cultural phenomenon in the conventional market. There is growing hostility between the high and poor classes. The community cannot afford the rising expenditures of healthcare, and the underclass occasionally decides not to take action.
Conclusion: This study shows that: first, following a health routine, using sensible methods They were simply adhering to medical protocol. The quarantine period will last 14 days in accordance with the health protocol. Second, confusing days occasionally adhere to health standards. They were following a process, but on another day they failed to follow it properly or a health protocol. Third, traders no longer care about COVID, despite the fact that they toil hard to earn a nice livelihood for their families.
Rainfall influence on the microclimate of caves and the risk assessment of mural deterioration in Dunhuang Mogao Grottoes, China
Authors: Liu Hongli , Zhang Qiang , Tian Wenshou , Zhang Zhengmo , Guo Qinglin , Gao Wenqiang 
Published: December 2022

Abstract
The Dunhuang Mogao Grottoes are famous for the exquisite murals and statues. The changes in temperature and humidity caused by rainfall easily trigger the salt diseases of murals. In order to prevent the further deterioration of murals, the influence of rainfall on the thermal and moisture environment of caves was analyzed through the environmental monitoring test. The results show that the temperature of the caves is basically unchanged, and the humidity changes in three stages of rising, maintaining and falling. The relative humidity and duration of high humidity show as of semi-closed cave > closed cave, small cave > large cave. The optimal time node of environment control of cave is aatm=acave, and the control condition is RH < 62%. The caves with small volume and large degree of connectivity to atmospheric environment are vulnerable objects. The disaster-deducing factor of mural deterioration is the accumulated rainfall in the next week, and the rainfall intensity is a reasonable parameter in risk monitoring and warning. The results have great significance for the risk prevention of mural deterioration and environment control of caves in Mogao grottoes.
Comparison of the Therapeutic Effect of Different Anticoagulation Regimens after Total Hip Arthroplasty based on ERAS
Authors: Cao Dede , Saad Muhammad , Pan Guojie , Jia Mingrui , Feng Pengfei , Ma Anning , Wang Yimeng , Zhang Liang 
Published: December 2022

Abstract
Objective
To compare the efficacy of low molecular weight heparin (LMWH), fondaparinux sodium (FPX), and rivaroxaban after total hip arthroplasty (THA) under Enhanced Recovery After Surgery (ERAS).
Method
The clinical data of patients who underwent primary THA due to hip joint disease in Ningxia Medical University General Hospital from October 2020 to June 2022 were retrospectively collected and analyzed. According to different anticoagulant methods, patients were divided into LMWH group (42 cases), FPX group (24 cases), and Rivaroxaban group (39 cases). Detect and record changes of blood coagulation-related factors, D-dimer, platelet (PLT) changes, blood routine, blood loss, lower limb vein thrombosis (DVT), pulmonary embolism, and allogeneic blood transfusion in the three groups perioperatively.
Result
There was no statistical significance in the comparison of coagulation indexes before the operation among the three groups (P > 0.05), but there was statistical significance in the comparison of PT and INR levels at 3 days after the operation (P < 0.05). There was a statistically significant difference between the Hb before operation and the Hct 3 days after operation in the three groups (P < 0.05). The postoperative drainage volume and overt blood loss of the three groups were statistically significant (P < 0.05), but there were no significant differences in intraoperative blood loss, hidden blood loss, and total blood loss (P > 0.05). There was no significant difference in VAS score, blood transfusion rate, and DVT incidence rate among the three groups before and 3 days after surgery (P > 0.05), and the treatment cost ratio of patients in LMWH group was lower than that of FPX group and Rivaroxaban group, the difference was statistically significant (P < 0.05).
Conclusion
Based on the ERAS concept, the use of LMWH, FPX, and Rivaroxaban after THA can effectively and safely prevent the occurrence of VTE and has no significant difference in postoperative pain, perioperative blood loss, and coagulation function. However, Rivaroxaban can be taken orally directly and has more advantages in pharmacological effects, while LMWH is cheaper and more economical.
Integration of scRNA-seq and Bulk-seq to Analyse the Infiltration of Monocytes in Pancreatic Cancer and Establish a Molecular Risk Model
Authors: Yao Wenchao , Liu Xuxu , Liu Tianming , Zheng Yi , Meng Ziang , Hao Yifei , Han Jinzuo , Wang Qiang , Lv Zhenyi , Xue Dongbo , Li Zhituo , Zhang Yingmei 
Published: December 2022

Abstract
Background
Many researches have confirmed that immunotherapy of tumor immune microenvironment is necessary. In pancreatic cancer, monocytes play an important role in poor prognosis, but the mechanism and prognosis prediction methods are unclear.
Methods
CIBERSORT was used to identify cellular immune score and evaluate the effect of each immune cell on prognosis. The gene modules related to monocytes were obtained by weighted correlation network analysis through WGCNA package. Consensus clustering was used to sort prognostic genes. The regression signature was generated by LASSO Cox analysis and verified by Cox analysis. The ssGSEA and TIDE algorithms were used to predict immune status and sensitivity to ICB. Finally, the expression levels of each gene were verified at tissue level and single-cell level.
Results
High infiltration of monocytes suggests poor prognosis of pancreatic cancer. 262 genes were significantly differentially expressed and prognostic after WGCNA analysis and cluster typing. The related 6 genes prognostic signature established by LASSO Cox analysis was verified to be an independent prognostic factor. The high-risk group had high infiltration of monocytes in the immune microenvironment and was more sensitive to ICBs. At the tissue level, all genes were highly expressed in cancer tissues. At the single-cell level, MET and MYEOV were significantly higher in malignant cells and lower in monocytes.
Conclusions
High infiltration of monocytes affects poor prognosis of pancreatic cancer, suggesting that the immune microenvironment has a certain research prospect for treatment of pancreatic cancer. The monocyte-related genes signature can accurately assess the prognostic risk of pancreatic cancer.
Exploring scenarios and challenges for AI in nursing care – results of an explorative sequential mixed methods study
Authors: Seibert Kathrin , Domhoff Dominik , Fürstenau Daniel , Biessmann Felix , Schulte-Althoff Matthias , Wolf-Ostermann Karin 
Published: December 2022

Abstract
Background and aim: While artificial intelligence (AI) is being adapted for various life domains and applications related to medicine and healthcare, the use of AI in nursing practice is still scarce. The German Ministry for Education and Research funded a study in order to explore needs, application scenarios, requirements, facilitators and barriers for research and development projects in the context of AI in nursing care. A mixed methods study including a stakeholder and expert workshop (N=21), expert interviews (N=14), an online survey (N=53) and a Datathon (N=80) was conducted with an emphasis on qualitative data.
Results: Needs and application scenarios encompassed the micro- and meso-level of care and derived from typical phenomena inherent to nursing care as well as from skill- and staff mix and consequences arising from staff shortages, from the extend of informal care and an associated need for information and education of informal caregivers and nursing assistants. Requirements for and characteristics of successful research and development projects included regulatory, processual, technological, ethical and legal aspects and supportive eco-systems.
Conclusion: A key element in the design of research projects remains participatory and demand-driven development that aims to bring AI solutions out of the lab and into practice. However, influencing factors remain that are outside the sphere of influence of individual projects, in particular the creation of resilient legal foundations for data use and the use of AI in practice, standardization of data structures and the establishment of infrastructures for data exchange across institutions and projects.
ERRα confers oncogenesis and cisplatin resistance via transcriptionally activating CCNE2 in breast cancer
Authors: Liu Jiahui , Feng Jinwen , Xuan Junfeng , Huang Ling , Xiao Bin , Zhu Yi , Kuang Zhenzhan , Zhang Weiyun , Song Lijie , Zhou Ye , Ding Chen , Zhang Hongbin , Li Linhai , Sun Zhaohui , Zhou Quan 
Published: December 2022

Abstract
Background: Platinum is widely used in the neoadjuvant and metastatic treatment of breast cancer, but increasingly drug resistance is the main cause of cancer recurrence and treatment failure. Our study aimed to investigate the mechanisms by which upregulation of estrogen-related receptor α (ERRα) induced chemoresistance in breast cancer.
Methods: Immunohistochemistry (IHC) was used to determine the expression of ERRα in breast cancer and adjacent tissues. Functional analyses (in vitro and in vivo) were performed to confirm the role of ERRα in cancerogenesis and cisplatin chemoresistance in breast cancer. RNA-sequencing, ChIP and dual luciferaseassays were performed to identify the mechanisms by which ERRα promotes chemoresistance in breast cancer.
Results: Analyses of ERRα expression among a case-control cohort of 63 annotated tumor specimens demonstrated that ERRα expression was highly expressed in breast cancer tissues. Overexpression of ERRα promoted cell proliferation and metastasis of breast cancer in vitro and in vivo, increased chemoresistant of cisplatin and enhanced the pluripotency; while ERRα knockdown resulted in the opposite effects. We show that ERRα can directly induce CCNE2 expression through binding its promoter region then enhanced the pluripotency of cancer cells and facilitated chemoresistance Overexpression of CCNE2 could reverse the sensitivity of breast cancer cells to cisplatin caused by ERRα depletion, thus resulting in accelerated tumor growth.
Conclusions: Our study demonstrates that ERRα acts as oncogene in breast cancer and promotes cisplatin resistance by regulating the transcription of CCNE2 and may serve as a therapeutic target in breast cancer.
Model Predictive Control of a Modular Multilevel Converter combined with a reduced average switching frequency sorting method
Authors: Proença Laís Ferreira Crispino , Rolim Luis Guilherme Barbosa 
Published: December 2022

Abstract
The modular multilevel converter (MMC) has been a subject of increasing interest for power electronics researchers, especially in HVDC applications. However, this paper considers the application scenario of a medium voltage distribution grid-connected MMC, using a model predictive control (MPC) with reduced number of states, as a control strategy to regulate the ac-side and circulating currents. In addition, an improved sorting algorithm is used to implement the task of maintaining the submodules capacitor voltages regulated, which results in a reduction of the average switching frequency. These control strategies are applied to a three-phase five-level MMC, and its performance is analyzed based on simulation results conducted in the environment of circuit simulations PSIM. Besides, an experiment was also carried out with a single-phase MMC prototype, and its results are presented, in order to prove the effectiveness of the control strategies proposed.
Exploring Racial and Economic Disparities in Exposure to Airborne Lead from Industrial Facilities in Kentucky, USA
Authors: Zhang Charlie H. , Sears Clara , Zierold Kristina 
Published: December 2022

Abstract
Background: Exposure to harmful lead is a critical public health concern due to its toxic nature and widespread distribution in the environment. Given the fact that policy solutions in the past several decades have significantly decreased the risks of environmental lead exposure, a remaining threat is toxic lead emissions from industrial facilities. This study examined the racial and economic disparities in proximity to lead-releasing industrial facilities and the concomitant lead exposure in Kentucky in the U.S.
Methods: We applied unique geospatial analysis methods including distance buffer, location quotients, and population-weighted exposures to analyze the spatial patterns of lead-releasing industrial facilities and lead exposure concerning environmental injustice between blacks and whites and between the below-poverty and above-poverty populations. Pearson’s linear correlation and paired samples t-test were performed to examine the statistical significance of racial and economic inequalities measured by distance to polluting facilities, lead concentration, and population-weighted exposure to lead.
Results: We identified a negative correlation between percent of the population that was black and distance to Toxic Release Inventory (TRI) sites (r = -0.240, p <0.001) and opposite results were observed for whites (r = 0.284, p <0.001). Likewise, median household income was positively associated with distance to TRI facilities (r = 0.197, p < 0.001) while poverty rate was inversely related to distance to TRI facilities (p = -0.189, p <0.001). Moreover, blacks and the below-poverty group had larger mean population-weighted lead exposures than whites and the above-poverty group respectively although the mean differences for each pair was statistically insignificant.
Conclusions: Results of this study provide new evidence supporting the environmental injustice proposition that assets low-income and ethnic minorities are more likely to reside in the vicinity of toxic-releasing industrial facilities and are therefore disproportionately exposed to airborne lead. Findings can help promote the need for reduced national ambient air quality standards for lead releases and mitigate environmental injustice.
Knowledge and Practice of Family Planning Among Pregnant Tribal Women in Southern India: An Observational Study
Authors: Muralidhar Kiranmayee , Nishimura Holly , Coursey Kate , Krupp Karl , Jaykrishna Poornima , Srini Vijaya , Madhivanan Purnima 
Published: December 2022

Abstract
BACKGROUND: A decrease in fertility and optimal birth spacing can reduce the risk of infant and maternal mortality. While fertility rates have decreased dramatically in India since the implementation of the national fertility program, fertility remains high among indigenous communities in rural India. This paper examines the determinants of contraceptive knowledge and practice by type (temporary or permanent) among tribal women in rural southern India.
METHODS: A cross sectional survey in Kannada was conducted of 303 married, pregnant tribal women in Mysore, India after obtaining informed consent. Univariate and multivariable analyses were carried out to determine the demographic and psychosocial factors associated with knowledge of contraceptive methods using Stata 14.0.
RESULTS: There was widespread knowledge about female sterilization, while only 39.3% of women reported hearing about one or more forms of temporary contraception, and 36.3% knew where to get them. The largest number of women had heard about copper-Ts (33.0%), followed by oral contraceptive pills (23.8%), condoms (11.9%), and injectables (4.6%). Only 2.7% of women reported ever using any form of temporary contraception. Results from the multivariable logistic regression indicated that knowledge of at least one form of temporary contraception was linked to higher age (AOR: 1.09; 95% CI: 1.02, 1.17), greater number of years of marriage (AOR: 0.90; 95% CI: 0.85, 0.96), and last birth in a government facility (AOR: 3.67; 95% CI: 1.99, 6.82).
CONCLUSIONS: The study revealed poor knowledge and utilization of temporary contraceptive methods among a tribal population in rural Mysore, India. Interventions aiming to increase knowledge of contraceptive options are important for birth spacing in this population and should target younger women and those without contact with government health facilities.
Estrogen Receptor-positive Breast Cancer Cells are Sensitized by Piperine to Chemo/Radio Therapy through Lowering the expression of a NHEJ repair protein DNA-PK
Authors: Shaheer Koniyan , Prabhu Swathi , Ali H. Shabeer , Lakshmanan Divya 
Published: December 2022

Abstract

Background
Gamma radiation(γ) and other DNA targeted compounds generate highly lethal DNA double-stranded breaks (DSBs) inducing the cells to undergo apoptosis. Non-homologous end joining (NHEJ), one of the primary DSB repair pathways, plays an important role in providing cancer cells resistance against radio/chemotherapeutic agents resulting in cancer progression and relapse. Downregulating DNA-PK, a key protein in NHEJ could result in the accretion of DSBs, thereby sensitizing the cells towards radiation.
Methods
Cytotoxicity assays, Clonogenic assays, DNA damage assays, Flowcytometry analysis, Confocal Microscopy, immunofluorescence, and Immunoblotting were carried out. Combinatorial index calculations were done using Compusyn Analysis and data analysis was done using one-way ANOVA and two-way ANOVA, where a p-value of ≤ 0.0001 was considered significant.
Results
Here we found that the treatment of MCF7 cells with piperine, lead to the accumulation of DSBs induced by γ-radiation through lowering DNA-PK complex (comprising of DNA-PKcs/Ku70/Ku80), by altering the estrogen receptor (ER) α /β ratio. Piperine lowered DNA-PK mediated NHEJ repair through its transcription factor, ERα. Upregulation of ERβ, a nuclear hormone transcription factor promoting tumor suppression positively correlated with lowered expression of ERα and DNA-PK marked by the accumulation of radiation-induced DSBs and DNA damage response, cell cycle arrest leading to the intrinsic pathway of apoptosis.
Conclusion
Breast Cancer cells may be sensitized to radiation by altering the expression of DNA-PKc Complex, a key dsDNA repair protein machinery through selective estrogen receptor modulation. This study proposes a new strategy for combating acquired radioresistance through estrogen receptor-mediated modulation of the NHEJ pathway.
Subcortical source localization based detection of verbal working memory stages using surface EEG.
Authors: Ranjan Shivani , Kumar Lalan 
Published: December 2022

Abstract
The verbal working memory (vWM) has been widely studied to understand individual’s cognitive development and learning. Role of subcortical structure in vWM features binding is also well established in literature. However, all such studies make use of intracranial electroencephalogram (iEEG) or fMRI because of their anatomical specificity. Additionally, simultaneous analysis of all subcortical structures, like hippocampus, amygdala, and thalamus, is sparsely present. In this work, subcortical source localization-based dipole activation pattern difference is utilized for detecting vWM stages using surface EEG. The EEG potential is converted into neuroimaging modality using sLORETA method. The EEG data was collected from fifteen healthy subjects for the proposed vWM framework. The localized source current information of targeted subcortical structures is utilized for quantitative comparisons and lateralization analysis to identify the significant subcortical structure during the vWM stages. Source domain performance analysis is compared with sensor domain counterparts in classifying encoding, recall, retrieval, and rest. A consistent improvement is seen in the source domain across all the subjects. In particular, the hippocampus is found to be an active and suitable node for the entire vWM process. Subject variability for memory stages is additionally captured. The findings are relevant in early detection of Alzheimer's disease (AD).
Symptom profiles of community cases infected by Influenza, RSV, rhinovirus, seasonal coronavirus, and SARS-CoV-2 variants of concern
Authors: Geismar Cyril , Nguyen Vincent , Fragaszy Ellen , Shrotri Madhumita , Navaratnam Annalan , Beale Sarah , Byrne Thomas , Fong Wing Lam , Yavlinsky Alexei , Kovar Jana , Hoskins Susan , Braithwaite Isobel , Aldridge Robert , Hayward Andrew 
Published: December 2022

Abstract
Respiratory viruses that were suppressed through previous lockdowns during the COVID-19 pandemic have recently started to co-circulate with SARS-CoV-2. Understanding the clinical characteristics and symptomatology of different respiratory viral infections can help address the challenges related to the identification of cases and the understanding of SARS-CoV-2 variants' evolutionary patterns.
Flu Watch (2006-2011) and Virus Watch (2020-2022) are household community cohort studies monitoring the epidemiology of influenza, respiratory syncytial virus, rhinovirus, seasonal coronavirus, and SARS-CoV-2, in England and Wales.
This study describes and compares the proportion of symptoms reported during illnesses infected by common respiratory viruses. The SARS-CoV-2 symptom profile increasingly resembles that of other respiratory viruses as new strains emerge. Increased cough, sore throat, runny nose, and sneezing are associated with the emergence of the Omicron strains. As SARS-CoV-2 becomes endemic, monitoring the evolution of its symptomatology associated with new variants will be critical for clinical surveillance.