bluuebunny/crossref_metadata_2025_split huggingface dataset:
The development of instruments for farmers’ participation in water management in tidal lowlands using confirmatory factor analysis
Authors: Tafarini Meitry Firdha , Yazid Muhammad , Suryadi F.X. , Prayitno Bambang , Faizal Muhammad , Khairul Fahmi Purba Khairul 
Published: January 2023

Water user associations or farmer groups carry out water management on tidal land. In its management, the participation of farmers in the group is necessary. This study aimed to examine the indicators of participation that positively affect the sustainability of tidal agriculture. The variables used in this study are participation (5 indicators), leadership (5 indicators), attitude & understanding (4 indicators), and utilization & maintenance (4 indicators). The research locations were in the tidal area of Telang Karya and Telang Rejo Village. The number of samples in this study was 245 farmers. This study used confirmatory factor analysis (CFA) by building the model of first-order CFA and second-order CFA. Evaluation of the model was done by looking at the Goodness of Fit Indexes, namely chi-square (χ2), root mean square error of approximation (RMSEA), CFI, TLI, GFI, and AGFI.
The research results on the second-order CFA resulted in a value of R2 = 137.414, and the model was a good fit. The results of the indicators analysis used were significant to be applied in tidal lowlands agriculture.
Light-Related Cutaneous Symptoms of Erythropoietic Protoporphyria and Associations With Light Sensitivity Measurements
Authors: Raef Haya S. , Rebeiz Lina , Leaf Rebecca Karp , Hughes Olivia , Jiang Paul , ElSeht Abrahim , Anderson Karl E. , Wheeden Kristen , Kochevar Irene , Elmariah Sarina B. , Dickey Amy K. 
Published: January 2023

ImportanceErythropoietic protoporphyria (EPP) is a rare and underdiagnosed genetic disease characterized by painful sensitivity to light. A better understanding and characterization of its light-induced cutaneous symptoms may aid in the identification of EPP in patients.ObjectivesTo describe the cutaneous symptoms of erythropoietic protoporphyria (EPP) and to determine if these symptoms are associated with the degree of light sensitivity.Design, Setting, and ParticipantsThis was a cross-sectional study of adolescent and adult (≥15 years) patients with EPP across the US conducted by a single academic hospital via a remotely administered survey, measurements of light sensitivity by light dosimetry and by text message symptom assessments. Data analyses were conducted from November 2020 to April 2022.ExposuresSunlight exposure.Main Outcomes and MeasuresSelf-reported symptoms and association with measured light sensitivity.ResultsThe study sample consisted of 35 patients with EPP (mean [SD] age, 39.1 (15.5) years; 21 [60%] female; 14 [40%] male; 35 [100%] White individuals). The patients’ median [range] skin tone was 3.0 (1.0-8.0), based on self-reporting from 1 (lightest) to 12 (darkest). A total of 24 participants completed the light dosimeter measurements. Phototoxic reactions were characterized by pain (97%; 34 patients), burning (97%; 34), tingling (97%; 34), pruritus (83%; 29), allodynia (89%; 31), improvement of symptoms with cold (89%; 31), achiness (24%; 12), fatigue (46%; 16), mild swelling (83%; 29), severe swelling (63%; 22), erythema (51%; 18), petechiae (40%; 14), skin cracking (43%; 15), scabbing (46%; 16), scarring (66%; 23), and other chronic skin changes (40%; 14). Patients with EPP reported that their hands, feet, and face were most sensitive to light and that their shoulders and legs were least sensitive; 25.7% (9 patient) reported no chronic skin changes, and 5.7% (2 patients) reported never having had any visible symptoms. None of these findings varied with the degree of light sensitivity except that lower overall light sensitivity was associated with lower ranked sensitivity of the neck and arms.Conclusions and RelevanceThe findings of this cross-sectional study suggest that patients with EPP have distinctive cutaneous symptoms that may aid in identification of this underdiagnosed disease. Characteristic EPP symptoms include light-induced cutaneous burning pain and occasional swelling, particularly over the hands, with a prodrome of pruritus and paresthesias. Minimal skin changes or the absence of visible skin changes during reactions to light, including lack of erythema, do not exclude an EPP diagnosis nor suggest low EPP disease burden.
Association Between State-Level Medicaid Expansion and Eviction Rates
Authors: Linde Sebastian , Egede Leonard E. 
Published: January 2023

ImportancePrior research has identified associations between housing insecurity and poor health outcomes.ObjectiveTo evaluate the association between US state Medicaid expansions and reductions in eviction; to examine the persistence of these associations and how they vary across US states and counties.Design, Setting, and ParticipantsThis cohort study of 25 398 county-year observations (across 40 states) used US eviction and census data for the years 2002 through 2018 (ie, 17 years). County-level associations were estimated using interactive fixed effects counterfactual estimators, and models were selected using cross validation. Across-county treatment association heterogeneities were assessed using multivariable regression methods. Analyses were performed in July of 2022.ExposureState-level Medicaid expansion under the Patient Protection and Affordable Care Act.Main Outcomes and MeasuresEviction judgments; eviction judgments per 100 renter-occupied households.ResultsAmong a total of 774 treated counties (with Medicaid expansion) and 720 control counties (untreated, without Medicaid expansion), mean (SD) eviction judgments for treated counties were 534.78 (1945.84) eviction judgments in the pre-2014 period (mean [SD] eviction rate, 2.25 [2.18] per 100 households), which decreased to 463.67 (1499.39) eviction judgments in the post-2014 period (mean [SD] eviction judgment rate, 2.02 [1.81] per 100 households). Control group mean (SD) county eviction judgments were 477.22 (1592.18) eviction judgments (mean [SD] eviction judgment rate, 1.91 per 100 households) pre-2014, and 490.22 (1575.19) eviction judgments (mean [SD] eviction judgment rate, 1.89 per 100 households) post-2014. Model estimates indicate that Medicaid expansion was associated with reductions in county eviction judgments by −66.49 (95% CI, −132.50 to −0.48; P = .047) and reductions of the eviction judgment rate by −0.25 (95% CI, −0.35 to −0.14; P &amp;lt; .001). Associations remained broadly consistent between 2014 and 2018, although some diminishment of associations occurred in 2018. Approximately 29% of the across-county treatment association variation was explained by across-state differences, while 9% was explained by county-level demographic and uninsurance differences.Conclusions and RelevanceIn this cohort study, Medicaid expansion was associated with reductions in eviction judgments and eviction judgment rates; however, these associations were found to vary considerably both across as well as within states (across counties). These findings suggest that the channel between Medicaid expansion and evictions is sensitive to state environments as well as county specific population demographics and uninsurance levels.
Association Between State Opioid Prescribing Limits and Duration of Opioid Prescriptions From Dentists
Authors: Chua Kao-Ping , Nguyen Thuy D. , Waljee Jennifer F. , Nalliah Romesh P. , Brummett Chad M. 
Published: January 2023

ImportanceIn part to prevent the harms associated with dental opioid prescriptions, most states have enacted policies limiting the duration of opioid prescriptions for acute pain. Whether these limits are associated with changes in the duration of opioid prescriptions written by dentists is unclear.ObjectiveTo evaluate the association between state opioid prescribing limits and the duration of opioid prescriptions from dentists.Design, Setting, and ParticipantsThis difference-in-differences cross-sectional study used data from the IQVIA Longitudinal Prescription Database, an all-payer database reporting prescription dispensing from 92% of retail pharmacies in the US. The sample included opioid prescriptions from dentists dispensed to children aged 0 to 17 years and adults 18 years or older from January 2014 through February 2020. Treatment states were those that implemented limits between January 2016 and December 2018. Control states were those that did not implement limits during the study period. Data on opioid prescribing limits were derived from the Prescription Drug Abuse Policy System. Data were analyzed from January 1 to September 30, 2022.ExposuresState opioid prescribing limits.Main Outcomes and MeasuresThe outcome was opioid prescription duration, as measured by days’ supply. The association between limits and duration was evaluated using a linear model with a 2-way fixed-effects specification. Covariates included patient characteristics, prescription characteristics, and indicators of implementation of prescription drug monitoring program use mandates. Separate analyses of data from adults and children were conducted owing to differences in the number of treatment states and restrictiveness of limits by age.ResultsThe adult analysis included 56 607 314 opioid prescriptions for 34 364 775 patients (18 448 788 females [53.7%]; mean [SD] age at the earliest fill, 44.0 [17.4] years) in 22 treatment states and 12 control states. The child analysis included 3 720 837 opioid prescriptions for 3 165 880 patients (1 740 449 females [55.0%]; mean [SD] age at the earliest fill, 14.4 [3.5] years) in 23 treatment states and 12 control states. In both analyses, the median (25th-75th percentile) duration of opioid prescriptions was 3.0 (2-5) days. Implementation of limits, most of which allowed up to a 7-day supply of opioids, was not associated with changes in the duration of opioid prescriptions for adults (mean days’ supply: −0.06 days; 95% CI, −0.11 to &amp;lt;0.001 days) or children (mean days’ supply: −0.07 days; 95% CI, −0.15 to 0.02 days).Conclusions and RelevanceIn this study of national pharmacy dispensing data, opioid prescribing limits were not associated with changes in the duration of opioid prescriptions from dentists. Future research should investigate the potential role of alternative interventions in reducing opioid prescribing by dentists.
Digital daydreaming: Introducing the spontaneous smartphone checking scale
Authors: Berntsen Dorthe , Hoyle Rick H. , Munkholm Møller Daniel , Rubin David C. 
Published: January 2023

AbstractSmartphones are a ubiquitous part of many people's lives, but little is known about their impact on everyday thought processes. Here we introduce the spontaneous smartphone checking scale (SSCS)—which measures the tendency to direct attention toward one's smartphone, unpreceded by external prompts (e.g., notifications, or alerts) and with no specific conscious goal in mind, as a parallel to mind‐wandering directed toward internal thoughts. The SSCS showed good psychometric properties and construct validity. It separated from measures of daydreaming and mind‐wandering by not loading on dimensions related to self‐consciousness, reflection, and rumination, but instead loading highly on a factor associated with other aspects of digital communication and concerns about public appearance on social media. This suggests that spontaneous smartphone checking serves different mental and social functions than internally generated spontaneous thought processes. We discuss possible long‐term effects of spontaneous smartphone checking taking up time for internally generated spontaneous thoughts.
Crocodile Skin‐Inspired Protective Composite Textiles with Pattern‐Controllable Soft‐Rigid Unified Structures
Authors: Mao Lizhou , Zhou Mengjuan , Yao Lu , Yu Hang , Yan Xuefeng , Shen Yue , Chen Wenshuai , Ma Pibo , Ma Yan , Zhang Songlin , Tan Swee Ching 
Published: January 2023

AbstractFunctional textiles with desirable protective properties (i.e., high cut‐, stab‐, and abrasion resistance) and wearability (i.e., excellent flexibility and permeability) remain unmet goals for personal protective equipment. Herein, inspired by crocodile skin, a unique and soft‐rigid unified structure (SRUS) is reported by integrating rigid protective blocks onto a soft textile substrate while obtaining a high cut‐, stab‐, and abrasion‐resistant composite textile that is flexible, waterproof, and breathable. Rigid blocks, consisting of epoxy resin reinforced by inorganic powders, strongly adhere to the soft textile surface with small intervals between each other via a pattern‐controllable integrated molding (PCIM) approach. Consequently, the SRUS design guarantees superior protective performance through rigid protective blocks and satisfactory flexibility and permeability via soft textiles and intervals. The SRUS textile achieves excellent cut‐resistance (58 N), the highest grades of stab‐ (38 N) and abrasion‐resistance (600 r mg−1), and good flexibility (65 mN cm) and permeability (60 mm s−1) values, indicating a distinct combination of desirable protective and wearable performance. The proposed SRUS protective textiles, incorporating the PCIM approach, offer a novel strategy for manufacturing functional soft composite textiles that combine high protective performance and good wearability, opening up a new avenue for the development of personal protective equipment.
Linear and Nonlinear Optical Field Manipulations with Multifunctional Chiral Coding Metasurfaces
Authors: Jiang Yifan , Liu Wenwei , Li Zhancheng , Choi Duk‐Yong , Zhang Yuebian , Cheng Hua , Tian Jianguo , Chen Shuqi 
Published: January 2023

AbstractOptical chirality, which describes the property of asymmetric light–matter interactions for different handedness of polarization, plays an important role in physical photonics, biochemical processes, and molecular recognition. Recently, asymmetric optical responses of chiral nanostructures provide a wide platform for arbitrary and artificial manipulation of optical chirality. Here, a design strategy is theoretically and experimentally introduced to realize a spin‐selective coding metasurface in both linear and third harmonic regimes with giant chirality. Significant chiral transmission and wavefront control are realized by a chiral coding metasurface composed of amorphous silicon (a‐Si) resonators with C2 symmetry. The resonators and the enantiomers are encoded with different transmission amplitude and phase. The information channels are expanded to six‐fold with simultaneous multi‐foci focusing and multi‐vortex generation operating in different polarization and linear/nonlinear channels. The nonlinear chiral high‐contrast imaging is also achieved for spin‐selective pattern information transmission. The study significantly expands the information capacity of coding metasurfaces, and can be readily applied in optical systems for information transmission in both linear and nonlinear regimes.
Visible‐light Induced Cerium‐catalyzed N‐Demethylation of N‐Methyl Amides under Air Conditions
Authors: Teng Qing‐Hu , Sun Gui‐Xia , Huang Fang‐Ping , Wang Kai , Liang Fu‐Pei 
Published: January 2023

AbstractA visible‐light induced cerium‐catalyzed N‐demethylation of N‐methyl amides under air atmosphere to the corresponding of N‐demethylated amides is presented. Upon irradiation the excited states of [CeIVCln]2− are able to activate N‐methyl amides. This reaction provides a methodology to cleave the C−N bond of amides under air conditions.magnified image
Electrochemical Synthesis of Hetero[7]helicenes Containing Pyrrole and Furan Rings via an Oxidative Heterocoupling and Dehydrative Cyclization Sequence
Authors: Salem Mohamed S. H. , Khalid Md. Imrul , Sako Makoto , Higashida Keigo , Lacroix Charlie , Kondo Masaru , Takishima Ryo , Taniguchi Taisei , Miura Masahiro , Vo‐Thanh Giang , Sasai Hiroaki , Takizawa Shinobu 
Published: January 2023

AbstractThe electrochemical synthesis of hetero[7]helicenes including pyrrole and furan rings has been established. A single electrochemical operation led to an oxidative heterocoupling and dehydrative cyclization sequence to afford oxaza[7]helicenes in 50–86% yields with 45–77% Faradic efficiencies. Their derivatization and chiroptical properties were also investigated.magnified image
Engineering Cyborg Bacteria Through Intracellular Hydrogelation
Authors: Contreras‐Llano Luis E. , Liu Yu‐Han , Henson Tanner , Meyer Conary C. , Baghdasaryan Ofelya , Khan Shahid , Lin Chi‐Long , Wang Aijun , Hu Che‐Ming J. , Tan Cheemeng 
Published: January 2023

AbstractNatural and artificial cells are two common chassis in synthetic biology. Natural cells can perform complex tasks through synthetic genetic constructs, but their autonomous replication often causes safety concerns for biomedical applications. In contrast, artificial cells based on nonreplicating materials, albeit possessing reduced biochemical complexity, provide more defined and controllable functions. Here, for the first time, the authors create hybrid material‐cell entities termed Cyborg Cells. To create Cyborg Cells, a synthetic polymer network is assembled inside each bacterium, rendering them incapable of dividing. Cyborg Cells preserve essential functions, including cellular metabolism, motility, protein synthesis, and compatibility with genetic circuits. Cyborg Cells also acquire new abilities to resist stressors that otherwise kill natural cells. Finally, the authors demonstrate the therapeutic potential by showing invasion into cancer cells. This work establishes a new paradigm in cellular bioengineering by exploiting a combination of intracellular man‐made polymers and their interaction with the protein networks of living cells.
Current Boosting of Self‐Aligned Top‐Gate Amorphous InGaZnO Thin‐Film Transistors under Driving Conditions
Authors: Park Jingyu , Choi Sungju , Kim Changwook , Shin Hong Jae , Jeong Yun Sik , Bae Jong Uk , Oh Chang Ho , Oh Saeroonter , Kim Dae Hwan 
Published: January 2023

AbstractOxide semiconductor transistors control the brightness and color of organic light‐emitting diode (OLED) displays in large‐screen televisions to portable telecommunications devices. Oxide semiconductor thin‐film transistors under driving conditions are required to maintain a steady current through the OLED for constant illuminance. Interestingly, for driving conditions under strong saturation where both gate and drain bias are high, a boosting phenomenon of the drain current is discovered, even with compensation of the threshold voltage. In this paper, the current boosting effect of self‐aligned InGaZnO transistors under driving conditions is comprehensively investigated. Based on experimental extraction methods, two distinct regions within the device are identified: an electron‐capture‐dominant region including electron trapping in the gate insulator and O–O dimer bond‐breaking, and an electron‐emission‐dominant region caused by peroxide formation. A dual‐transistor‐in‐series model is proposed, where each region is modeled as a local transistor. The current boosting phenomena as a function of time are well‐reproduced for various channel length devices, which validate the accuracy of the model. Better understanding of the underlying mechanisms enables increased effectiveness of compensation schemes for transistors under long‐term current‐driving conditions.
Ein neues bakterielles, von Adenosin abgeleitetes Nukleosid als Beispiel für RNA‐Modifikationsschäden
Authors: Bessler Larissa , Vogt Lea‐Marie , Lander Marc , Dal Magro Christina , Keller Patrick , Kühlborn Jonas , Kampf Christopher J. , Opatz Till , Helm Mark 
Published: January 2023

AbstractDie Bereiche RNA‐Modifikation und RNA‐Schaden weisen beide eine Vielzahl nicht‐kanonischer Nukleosidstrukturen auf. Während sich RNA‐Modifikationen zur Verbesserung der RNA‐Funktion entwickelt haben, impliziert die Bezeichnung RNA‐Schaden negative Auswirkungen. Auf Grundlage der Markierung mit stabilen Isotopen und Massenspektrometrie berichten wir von der Identifizierung und Charakterisierung von 2‐Methylthio‐1,N6‐ethenoadenosin (ms2ϵA), welches mit 1,N6‐Ethenoadenin, einer Läsion, die durch Exposition von Nukleinsäuren gegenüber alkylierenden Chemikalien in vivo entsteht, verwandt ist. Im Gegensatz dazu zeigte ein ausgefeiltes Konzept zur Isopren‐Markierung, dass die Biogenese von ms2ϵA die Spaltung eines Prenylrests in der bekannten transfer‐RNA (tRNA)‐Modifikation 2‐Methylthio‐N6‐isopentenyladenosin (ms2i6A) beinhaltet. Die relative Häufigkeit von ms2ϵA in tRNAs von translatierenden Ribosomen lässt eine verminderte Funktionalität im Vergleich zur ursprünglichen RNA‐Modifikation vermuten, wodurch die Natur der neuen Struktur in einer neu wahrgenommenen Überschneidung der beiden zuvor getrennten Bereiche, nämlich ein RNA‐Modifikationsschaden, begründet wird.
Untersuchung einer Wasserstoff‐π Wechselwirkung in einem eingeschlossenen Wassermolekül im Festkörper
Authors: Bartalucci Ettore , Malär Alexander A. , Mehnert Anne , Kleine Büning Julius B. , Günzel Lennart , Icker Maik , Börner Martin , Wiebeler Christian , Meier Beat H. , Grimme Stefan , Kersting Berthold , Wiegand Thomas 
Published: January 2023

AbstractDer Nachweis und die Charakterisierung von eingeschlossenen Wassermolekülen in chemischen Gebilden und Biomakromolekülen ist weiterhin eine Herausforderung für feste Materialien. Wir präsentieren hier Protonen‐detektierte Festkörper‐Kernspinresonanzspektroskopie (NMR) Experimente bei Rotationsfrequenzen von 100 kHz um den magischen Winkel und bei hohen statischen Magnetfeldstärken (28.2 T), die den Nachweis eines einzelnen Wassermoleküls ermöglichen, das im Calix[4]aren‐Hohlraum eines Lanthan‐Komplexes durch eine Kombination von drei Arten nicht‐kovalenter Wechselwirkungen fixiert ist. Die Protonenresonanzen des Wassers werden bei einer chemischen Verschiebung nahe Null ppm nachgewiesen, was wir durch quantenchemische Berechnungen bestätigen. Berechnungen mit der Dichtefunktionaltheorie zeigen, wie empfindlich der Wert der chemischen Verschiebung der Protonen auf Wasserstoff‐π‐Wechselwirkungen reagiert. Unsere Studie unterstreicht, wie sich die Protonen‐detektierte Festkörper NMR zur Methode der Wahl für die Untersuchung schwacher nicht‐kovalenter Wechselwirkungen entwickelt, die einen ganzen Zweig molekularer Erkennungsvorgänge in der Chemie und Biologie bestimmen.
ZIF‐8 Nanoparticles Evoke Pyroptosis for High‐Efficiency Cancer Immunotherapy
Authors: Ding Binbin , Chen Hao , Tan Jia , Meng Qi , Zheng Pan , Ma Ping'an , Lin Jun 
Published: January 2023

AbstractAlthough zeolitic imidazolate framework‐8 (ZIF‐8) has been applied in various tumor therapies, the intrinsic immunogenicity remains unclear. Here, we initiatively discover that ZIF‐8 nanoparticles (NPs) can intrinsically induce pyroptosis by a caspase‐1/gasdermin D (GSDMD)‐dependent pathway. The pyroptotic cell death is accompanied by necrosis and immunogenic cell death (ICD) simultaneously for efficient in situ immunity initiation. Meanwhile, carbonyl cyanide m‐chlorophenyl hydrazone (CCCP), a mitochondrial depolarizing agent, is successfully loaded into ZIF‐8 NPs and found to further enhance the pyroptosis process. Collectively, the obtained Pluronic F127‐modified CCCP‐incorporated ZIF‐8 NPs (F127ZIF‐8CCCPNPs) activate antitumor immunity and reprogram immunosuppressive tumor microenvironment (TME), realizing high‐efficiency tumor growth inhibition. This work will facilitate biomedicine applications of ZIF‐8 and provide good inspiration for pyroptosis‐induced cancer therapy.