bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategic Research, Innovation and Implementation Agenda for Digital Language Equality in Europe by 2030
Authors: Rehm Georg , Way Andy 
Published: June 2023

AbstractThis chapter presents the ELE Programme (ELE Consortium 2022). Reacting to the landmark resolution (European Parliament 2018), its vision is to achieve digital language equality in Europe by 2030. The programme was prepared jointly with many stakeholders from the European Language Technology, Natural Language Processing, Computational Linguistics and language-centric AI communities, as well as with representatives of relevant initiatives and associations, and language communities. Europe still suffers from strong inequalities in terms of technology support of its languages. English is still by far the language with the best technological support, followed by a cluster of three languages (German, Spanish, French) that already have only half the technological support of English. More than half of the around 90 languages surveyed have either weak or no technological support at all. The ELE Programme is foreseen to be a shared, long-term funding programme tailored to Europe’s needs, demands and values. For the EU we foresee the role of providing resources for coordinating the programme, for providing shared infrastructures, for maintaining the scientific goals and programme principles, etc. The participating countries have the role of providing resources for the development of technologies and datasets for their own languages. Key goals are to reduce the technology gap between English and all other European languages and to address the lack of available language data. The ELE Programme tackles the following overarching themes: Language Modelling, Data and Knowledge, Machine Translation, Text Understanding and Speech. These interconnected themes focus upon the socio-political goal of establishing DLE in Europe and on the scientific goal of Deep Natural Language Understanding, both by 2030.1
Language Report Bulgarian
Authors: Koeva Svetla 
Published: June 2023

AbstractThis chapter reports on the current status of technology support for Bulgarian and highlights certain gaps. The analysis is based on the services and resources available in the European Language Grid in early 2022. While the LT field as a whole has significantly progressed in the last ten years, we conclude that there is still a yawning technological gap between English and Bulgarian, and even between German, French, Italian, Spanish and Bulgarian. It is exactly this distance that needs to be ideally eliminated, if not at least reduced, in order to move towards Digital Language Equality for Bulgarian.
Radiation Exposure in Interventional Stroke Treatment
Authors: Bärenfänger Felix , Schramm Peter , Rohde Stefan 
Published: June 2023

Abstract
Purpose
To evaluate patient-related radiation exposure in interventional stroke treatment by analyzing data from the German Society for Interventional Radiology and Minimally Invasive Therapy (DeGIR) and the German Society of Neuroradiology (DGNR) quality registry from 2019–2021.

Methods
The DeGIR/DGNR registry is the largest database of radiological interventions in Germany. Since the introduction of the registry in 2012, the participating hospitals have entered clinical and dose-related data on the procedures performed. To evaluate the current diagnostic reference level (DRL) for mechanical thrombectomy (MT) in stroke patients, we analyzed interventional data from 2019 to 2021 with respect to the reported dose area product (DAP) and factors that might contribute to the radiation dose, such as the localization of the occlusion, technical success using the modified treatment in cerebral ischemia (mTICI) score, number of passages, technical approach, additional intracranial/extracranial stenting, and case volume per center.

Results
A total of 41,538 performed MTs from 180 participating hospitals were analyzed. The median DAP for MT was 7337.5 cGy∙cm2 and the corresponding interquartile range (IQR) Q25 = 4064 cGy∙cm2 to Q75 = 12,263 cGy∙cm2. In addition, we discovered that the dose was significantly influenced by occlusion location, number of passages, case volume per center, recanalization score, and additional stenting.

Conclusion
We conducted a retrospective study on radiation exposure during MT in Germany. Based on the results of more than 41,000 procedures, we observed that the DRL of 14,000 cGy·cm2 is currently appropriate but may be lowered over the next years. Furthermore, we identified several factors that contribute to high radiation exposure. This can aid in detecting the cause of an exceeded DRL and optimize the treatment workflow.
Optimierung der Risiko- und Krisenkommunikation von Regierungen, Behörden und Organisationen der Gesundheitssicherung – Herausforderungen in lang anhaltenden Krisen am Beispiel der COVID-19-Pandemie
Authors: Schulze Annett , Brand Fabian , Leschzyk Dinah Kristin , Beuthner Michael , Biegert Alena , Bomnüter Udo , Boy Bettina , Bucher Hans-Jürgen , Frau Robert , Hubig Marvin , Löffelholz Martin , Mayer Johanne , Pliquet Carolyn , Radechovsky Johanna , Schleicher Kathrin , Ulbrich Kirsten 
Published: June 2023

ZusammenfassungDie COVID-19-Pandemie illustriert die besondere Bedeutung von Risiko- und Krisenkommunikation. Behörden und Politik stehen vor der Herausforderung, in einer dynamischen Lage mit einer Vielzahl von Daten umzugehen, diese zu überprüfen und zielgruppengerecht zu kommunizieren. Verständliche und eindeutige Informationen zu Risiken und Handlungsoptionen tragen maßgeblich zu einer Steigerung der objektiven und subjektiven Sicherheit der Bevölkerung bei. Es besteht daher ein großer Bedarf, die Erfahrungen aus der Pandemie in die Optimierung der Risiko- und Krisenkommunikation einfließen zu lassen.Die Digitalisierung ermöglicht multimodale Arrangements – also die Kombination aus Text, Abbildungen, Grafik, Icons und z. T. Bewegtbilder, Animationen und Ton. Diese spielen auch in der digitalen Risiko- und Krisenkommunikation eine zunehmend wichtigere Rolle. Von Interesse ist, inwiefern das kommunikative Zusammenspiel von Behörden, Medien und weiteren Öffentlichkeitsakteur/-innen in Vorbereitung auf und zur Bewältigung von Krisen angesichts einer komplexen Öffentlichkeit mit Hilfe zielgruppenspezifischer Kommunikation verbessert und wie Rechtssicherheit für die behördliche und mediale Praxis gewährleistet werden kann. Dementsprechend verfolgt der Beitrag 3 Ziele:1. Er beschreibt die Herausforderungen, vor denen Behörden und mediale Akteur/-innen in der Pandemiekommunikation stehen.2. Er zeigt, welche Rolle multimodale Arrangements spielen und welcher Forschungsperspektiven es bedarf, um die Komplexität des kommunikativen Krisenhandelns im föderalen System zu erfassen.3. Er begründet, wie ein interdisziplinärer Forschungsverbund aus Medien‑, Kommunikations- und Rechtswissenschaft Erkenntnisse zum evidenzbasierten Einsatz multimodaler Kommunikation gewinnen kann.
Medical Care Use Among Patients with Monogenic Osteoporosis Due to Rare Variants in LRP5, PLS3, or WNT1
Authors: Verdonk S. J. E. , Storoni S. , Zhytnik L. , Zhong W. , Pals G. , van Royen B. J. , Elting M. W. , Maugeri A. , Eekhoff E. M. W. , Micha D. 
Published: June 2023

AbstractPathogenic variants in the LRP5, PLS3, or WNT1 genes can significantly affect bone mineral density, causing monogenic osteoporosis. Much remains to be discovered about the phenotype and medical care needs of these patients. The purpose of this study was to examine the use of medical care among Dutch individuals identified between 2014 and 2021 with a pathogenic or suspicious rare variant in LRP5, PLS3, or WNT1. In addition, the aim was to compare their medical care utilization to both the overall Dutch population and the Dutch Osteogenesis Imperfecta (OI) population. The Amsterdam UMC Genome Database was used to match 92 patients with the Statistics Netherlands (CBS) cohort. Patients were categorized based on their harbored variants: LRP5, PLS3, or WNT1. Hospital admissions, outpatient visits, medication data, and diagnosis treatment combinations (DTCs) were compared between the variant groups and, when possible, to the total population and OI population. Compared to the total population, patients with an LRP5, PLS3, or WNT1 variant had 1.63 times more hospital admissions, 2.0 times more opened DTCs, and a greater proportion using medication. Compared to OI patients, they had 0.62 times fewer admissions. Dutch patients with an LRP5, PLS3, or WNT1 variant appear to require on average more medical care than the total population. As expected, they made higher use of care at the surgical and orthopedic departments. Additionally, they used more care at the audiological centers and the otorhinolaryngology (ENT) department, suggesting a higher risk of hearing-related problems.
Co-occurrence of Spondyloepiphyseal Dysplasia and X-Linked Hypophosphatemia in a Three-Generation Chinese Family
Authors: Ma Jian , Zhang Ye , Ding Xiaoxiao , Liang Zhijiang , Yang Chaoxiang , Deng Zhi , He Hui , Guan Zhihong , Zeng Chunhua , Lin Yunting , Luo Xianqiong 
Published: June 2023

AbstractRare genetic skeletal disorders (GSDs) remain the major problem in orthopedics and result in significant morbidity in patients, but the causes are highly diverse. Precise molecular diagnosis will benefit management and genetic counseling. This study aims to share the diagnostic experience on a three-generation Chinese family with co-occurrence of spondyloepiphyseal dysplasia (SED) and X-linked hypophosphatemia (XLH), and evaluate the therapeutic effects of two third-generation siblings. The proband, his younger brother, and mother presented with short stature, skeletal problems, and hypophosphatemia. His father, paternal grandfather, and aunt also manifested short stature and skeletal deformities. Whole exome sequencing (WES) of proband–brother–parents initially only found the proband and his younger brother had a pathogenic c.2833G > A(p.G945S) variant in the COL2A1 gene inherited from their father. Re-analysis of WES uncovered the proband and his younger brother also harbored a pathogenic ex.12 del variant in the PHEX gene transmitted from their mother. Sanger sequencing, agarose gel electrophoresis, and quantitative polymerase chain reaction proved these results. The proband and his younger brother were confirmed to have a paternally inherited SED and a maternally inherited XLH. During a 2.8-year follow-up, these two siblings remained short stature and hypophosphatemia, but their radiographic signs and serum bone alkaline phosphatase levels were improved with treatment of oral phosphate and calcitriol. Our study presents the first report of co-occurrence of SED and XLH, shows the possibility that two different rare GSDs co-exist in a single patient, and alerts clinicians and geneticists to be cautious about this condition. Our study also suggests that next-generation sequencing has limit in detecting exon-level large deletions.
Comparison of schlieren-based techniques for measurements of a turbulent and wavy free surface
Authors: Bheeroo Vivek , Mandel Tracy L. 
Published: June 2023

AbstractThe free surface at an air–water interface can provide information regarding bathymetric complexities, as well as the subsurface flow. We present a comparison of the performance of two recent advances in light-based optical techniques for free surface measurements, total internal reflection-deflectometry and moon-glade background-oriented schlieren, with the more established method of free surface synthetic schlieren. We make use of an optical flow algorithm over the more traditional digital image correlation, in order to obtain higher spatial resolution data across the imaged free surface domain. The optical flow algorithm presents additional benefits, such as computational efficiency and robustness in capturing large displacements and straining of tracked features. The three optical techniques are assembled in synchronization to image two free surface conditions: (1) a free surface being impinged upon by an underlying turbulent, free-shear flow and (2) a random and irregular wave field induced by a free jet. Using the high-resolution measurements, we provide insight on the emergence of multiple free surface dynamics for a turbulent free surface. We present a comprehensive discussion on the benefits and drawbacks of each technique, including suggestions on the suitability of each technique for several experimental constraints.
Graphical abstract
Wall-shear-stress measurements using volumetric µPTV
Authors: Fuchs Thomas , Bross Matthew , Kähler Christian J. 
Published: June 2023

AbstractAccurately determining the wall-shear-stress, $$\tau _\textrm{w}$$

τ
w

, experimentally is challenging due to small spatial scales and large velocity gradients present in the near-wall region of turbulent flows. To avoid these resolution requirements, several indirect iterative fitting methods, most notably the Clauser chart method, exist for determining $$\overline{\tau }_{w}$$

τ
¯

w

by fitting the mean velocity profile further away from the near-wall region in the log-law layer. These methods often require proper selection of fitting constants, assumptions of a canonical flow state, and other empirical-based generalizations. To reduce the amount of ambiguity, determining the near-wall velocity gradient by assuming a linear relationship between the mean streamwise velocity and wall normal distance in the viscous sublayer can be used. However, this requires an accurate unbiased measurement of the near-wall velocity profile in the region below five viscous spatial units, which can be less than 50 µm for high Reynolds number flows. Therefore, in this study a method for a volumetric defocusing microparticle tracking velocimetry method is presented that is capable of resolving the flow in the viscous sublayer of a turbulent boundary layer up to $$U_{\textrm{e}}=44.7\,$$

U
e

=
44.7

m/s ($$Re_{\theta }=27250$$

R

e
θ

=
27250

). This method allows for the measurement of the near-wall flow through a single optical access for illumination and imaging and serves as an excellent complement of larger scale measurements that require near-wall information. The $$\overline{\tau }_\textrm{w}$$

τ
¯

w

values determined from the defocusing approach were found to be in good agreement values obtained from a simultaneous parallax PTV measurement. Furthermore, analysis of the diagnostic plot and cumulative distribution of measured fluctuations in the near-wall region, showed that both methods are capable of accurately determining mean velocity and fluctuation profiles in the self-similar viscous sublayer region.
Submandibular gland involvement in oral cavity squamous cell carcinoma: a retrospective multicenter study
Authors: Iocca Oreste , Copelli Chiara , Garzino-Demo Paolo , Ramieri Guglielmo , Rubattino Stefano , Sedran Luca , Volpe Fabio , Manfuso Alfonso , Longo Francesco , Sanchez-Aniceto Gregorio , Rivero-Calle Álvaro , García-Sánchez Aitor , Pellini Raul , Petruzzi Gerardo , Moretto Silvia , Al-Qamachi Laith , Aga Hiba , Ridley Stephen , Di Maio Pasquale 
Published: June 2023

Abstract
Background
The submandibular gland (SMG) is routinely excised during neck dissection. Given the importance of the SMG in saliva production, it is important to understand its involvement rate by cancer tissue and the feasibility of its preservation.

Methods
Retrospective data were collected from five academic centers in Europe. The study involved adult patients affected by primary oral cavity carcinoma (OCC) undergoing tumor excision and neck dissection. The main outcome analyzed was the SMG involvement rate. A systematic review and a meta-analysis were also conducted to provide an updated synthesis of the topic.

Results
A total of 642 patients were enrolled. The SMG involvement rate was 12/642 (1.9%; 95% CI 1.0–3.2) when considered per patient, and 12/852 (1.4%; 95% CI 0.6–2.1) when considered per gland. All the glands involved were ipsilateral to the tumor. Statistical analysis showed that predictive factors for gland invasion were: advanced pT status, advanced nodal involvement, presence of extracapsular spread and perivascular invasion. The involvement of level I lymph nodes was associated with gland invasion in 9 out of 12 cases. pN0 cases were correlated with a reduced risk of SMG involvement. The review of the literature and the meta-analysis confirmed the rare involvement of the SMG: on the 4458 patients and 5037 glands analyzed, the involvement rate was 1.8% (99% CI 1.1–2.7) and 1.6% (99% CI 1.0–2.4), respectively.

Conclusions
The incidence of SMG involvement in primary OCC is rare. Therefore, exploring gland preservation as an option in selected cases would be reasonable. Future prospective studies are needed to investigate the oncological safety and the real impact on quality of life of SMG preservation.
The three pillars in treating antibody-mediated encephalitis
Authors: Macher S. , Bsteh G. , Pataraia E. , Berger T. , Höftberger R. , Rommer P. S. 
Published: June 2023

SummaryThe rapid initiation of immunotherapy has a decisive impact on the course of the disease in patients with antibody-mediated encephalitis (AE). The importance of treating AE with antiseizure medication and antipsychotics is discussed controversially; however, standardized procedures should be ensured, especially for the initiation of treatment in severe disease. Recommendations and guidelines for further interventions in refractory courses are needed. In this review, we contrast the three mainstays of treatment options in patients with AE and attempt to highlight the importance of 1) antiseizure therapy, 2) antipsychotic therapy, and 3) immunotherapy/tumor resection from today’s perspective.
Krebsberatung: „Gut gegen Kopfkino“
Authors: Wünsch Alexander , Bayer Oliver , Adlkofer Ulrike , Besseler Markus , Bruns Gudrun , Bochmann Kathrin , Bohrmann Monika , Eckhardt Andrea , Engesser Deborah , Götz Sabine , Holz Franziska , Hegestweiler Annette , Ihrig Andreas , Jakob Johannes , Jung Marianne , Lückert Frank , Pereira Lita Laura , Petridis Franziska , Perzlmaier Heide , Reuthlinger Claudia , Singer Susanne 
Published: June 2023

Zusammenfassung
Einleitung
Männer nutzen seltener psychosoziale Unterstützung als Frauen, auch wenn sie psychisch belastet sind. Ziel war, verschiedene Maßnahmen zu entwickeln, die Männern die Inanspruchnahme der Angebote von Krebsberatungsstellen erleichtern sollen. Dieser Beitrag gibt die Erfahrungen aus der Praxis wieder, die wir im Rahmen der Studie WAG-ES! gewinnen konnten.

Methode
Ein Maßnahmenpaket wurde in vier Schritten entwickelt, dabei auf Praxistauglichkeit und Umsetzbarkeit geprüft und zu einem Katalog zusammengefasst. Anschließend wurde es in einer mehrmonatigen Pilotierungs- und Interventionsphase in sieben Krebsberatungsstellen umgesetzt und an die jeweiligen Gegebenheiten adaptiert.

Ergebnisse
Das Maßnahmenpaket besteht aus vier Säulen: Öffentlichkeitsarbeit, Schnittstellen & Zuweisende, strukturelle Veränderungen und männerspezifische Aktivitäten. Ziel der Öffentlichkeitsarbeit ist, Zuweisende über das Beratungsangebot und männerspezifische Angebote zu informieren und mögliche Fehlvorstellungen über psychosoziale Beratung zu korrigieren. Die Zuweisenden wurden gezielt angesprochen und hatten eine Schlüsselfunktion. Strukturelle Veränderungen, zum Beispiel eine Abendsprechstunde, konnten leicht umgesetzt werden. Besonders wichtig waren männerspezifische Angebote. Dabei wurde die körperliche Aktivität oder Informationsvermittlung an erste Stelle gesetzt. Später, wenn sich eine Vertrautheit entwickelt hatte, konnten auch emotional oder schambesetzte Themen angesprochen und bearbeitet werden.

Schlussfolgerung
Das erarbeitete Maßnahmenpaket ist praxistauglich und kann in der Breite eingesetzt werden.
How material flow cost accounting contributes to the SDGs through improving management decision-making
Authors: Kokubu Katsuhiko , Kitada Hirotsugu , Nishitani Kimitaka , Shinohara Aki 
Published: June 2023

AbstractThe purpose of this study is to clarify how material flow cost accounting (MFCA) can contribute to the SDGs and indicate how to introduce it into a company. First, we undertake a literature review to examine which SDGs MFCA can potentially contribute to. We then analyse the interplay between MFCA and management decision-making on the SDGs using an MFCA-LCA integrated model. Finally, we discuss how to introduce MFCA into a company to integrate the SDGs into management decision-making with reference to the SDG Compass. The main contributions are as follows: First, we revealed that MFCA could potentially contribute to multiple goals in the SDGs. Second, we clarified that MFCA could integrate the SDGs into actual management decision-making. Third, we suggested appropriate steps for implementation, regarding how managers should introduce MFCA into the management process on the condition that it does not prioritise economic benefit over social and environmental benefits in contributing to the SDGs. Therefore, this study provides evidence that MFCA can contribute to the SDGs by integrating them into management decision-making, and suggests appropriate implementation steps for promoting the pursuance of SDGs in any company.
A novel dynamic rockfall susceptibility model including precipitation, temperature and snowmelt predictors: a case study in Aosta Valley (northern Italy)
Authors: Bajni Greta , Camera Corrado A. S. , Apuani Tiziana 
Published: June 2023

AbstractThe overarching goal of the study was the development of a potentially dynamic rockfall susceptibility model by including climate predictors. The work is based on previously defined critical thresholds relating three climate indices — effective water inputs (EWI), wet-dry cycles (WD) and freeze–thaw cycles (FT) — and rockfall occurrence. The pilot area is located in the Aosta Valley region (Italian Western Alps). The susceptibility model settings were optimized through a stepwise procedure, carried out by means of generalized additive models (GAM). Predictors included topographic, climatic and additional snow-related variables. As climatic predictors, the mean annual threshold exceedance frequency was calculated for each index. All models were developed including an automatic penalization of statistically non-significant variables (i.e. shrinkage). The initial susceptibility model was set without considering potential inventory bias. Secondly, a “visibility mask” was produced to limit the modelling domain according to the rockfall event census procedures. Thirdly, GAMs functional relationships were analysed to verify the physical plausibility of predictors. Finally, to reduce concurvity, a principal component analysis (PCA) including climatic and snow-related predictors was carried out. Key findings were as follows: (i) ignoring inventory bias led to excellent model performance but to physically implausible outputs; (ii) the selection of non-rockfall points inside a “visibility mask” is effective in managing inventory bias influence on outputs; (iii) the inclusion of climate predictors resulted in an improvement of the physical interpretability of the associated models and susceptibility maps, being EWI, WD and the maximum cumulated snow melting the most important physically plausible climate predictors; (iv) the PCA strategy can efficiently reduce model concurvity.