bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of GWAS and eGWAS to screen candidate genes underlying green head traits in male ducks
Authors: Wang Jianmei , Jiang Shuaixue , Xi Yang , Qi Jingjing , Ma Shengchao , Li Liang , Wang Jiwen , Bai Lili , He Hua , Xu Hengyong , Liu Hehe 
Published: May 2023

AbstractSexually dimorphic plumage coloration is widespread in birds. The male possesses more brightly colored feathers than the female. Dark green head feathers comprise one of the most typical appearance characteristics of the male Ma duck compared with the female. However, there are noticeable individual differences observed in these characteristics. Herein, genome‐wide association studies (GWAS) were employed to investigate the genetic basis of individual differences in male duck green head‐related traits. Our results showed that 165 significant SNPs were associated with green head traits. Meanwhile, 71 candidate genes were detected near the significant SNPs, including four genes (CACNA1I, WDR59, GNAO1 and CACNA2D4) related to the individual differences in the green head traits of male ducks. Additionally, the eGWAS identified three SNPs located within two candidate genes (LOC101800026 and SYNPO2) associated with TYRP1 gene expression, and might be important regulators affecting the expression level of TYRP1 in the head skin of male ducks. Our data also suggested that transcription factor MXI1 might regulate the expression of TYRP1, thereby causing differences in the green head traits among male ducks. This study provided primary data for further analysis of the genetic regulation of duck feather color.
Is there a representative quality‐of‐life questionnaire for patients with AL amyloidosis?—systematic literature review
Authors: Bristogiannis Sotirios , Khwaja Jahanzaib , Lwin Yadanar , Wechelaker Ashutosh , Wisniowski Brendan , Mahmood Ayesha Shameem , Sachchithanantham Sajitha , Kyriakou Charalampia 
Published: May 2023

SummarySystemic AL amyloidosis is an incurable condition with various presentations and may cause multiple complications related to organ involvement. As survival has improved, disease and therapy‐related quality of life (QoL) is becoming an increasingly important treatment endpoint. We review the literature summarising the utilised QoL questionnaires (QLQs) and assess their validity according to COSMIN (Consensus‐based Standards for the Selection of Health Measurement Instruments) standards. Thirteen retrospective observational studies and thirty‐two prospective clinical trials were analysed. Most QLQs are generic or only validated in populations with distinct complications of the disease. None meet ‘strong evidence’ for validation in this context. There is a need to develop a disease‐specific QLQ, which could inform treatment choices and facilitate the approval of novel therapies.
The potential role of social and familial networks in shaping the well‐being of children in shelters for women survivors of intimate partner violence
Authors: Vass Anat , Haj‐Yahia Muhammad M. 
Published: May 2023

AbstractChildren living in households where severe intimate partner violence (IPV) exists sometimes move with their mothers to shelters for battered women. Although there is an increased interest in research exploring children's exposure to IPV, little is known about children's subjective experiences during their stay in shelters. The present study examines children's views of their disconnection from their social and familial networks during their stay in a shelter. Using qualitative methods, 32 children, ages 7–12 years, who resided in a shelter were interviewed. Thematic analysis was implemented to develop codes and themes. The following five themes emerged from the data analysis: (a) absence of grandparents, (b) worry about older siblings, (c) disconnection from the neighbourhood, (d) missing their house and (e) disconnection from previous school and classmates. Findings suggest that children's disconnection from previous formal and informal networks significantly affected their well‐being. The findings are discussed and interpreted in light of selected key concepts of Bronfenbrenner's bioecological model. The limitations of this study are discussed, along with implications for future research, as well as highlights for future intervention.
Children's literature as a motivational factor for physical activities through the example of Jaroslav Foglar
Authors: Jirásek Ivo , Macků Richard , Němec Jiří 
Published: May 2023

AbstractDespite many philosophical and scientific appeals, physical inactivity, especially in children and young people, remains one of the most serious problems of contemporary civilisation. In our sub‐study of wider research, we focus on the use of Czech fiction and comics by Jaroslav Foglar as a motivational factor to increase readers' physical activity. The respondents (n = 1174) were mostly adults who had spent their childhood or adolescence reading the works of Jaroslav Foglar. These people valued exercise (70%) in this reading, with a high correlation (0.73) to a healthy lifestyle (abstinence from alcohol and smoking). For 57% of the respondents, these values from reading also become an inspiration for application in life (there is a causal link between the degree of awareness of being influenced by the work and the actual application of the physical activity), with even higher values recorded for camping and being in a natural environment, as well as moral behaviour, ethical principles, and helping others. Thus, we can confirm that the inspiration of the fictional world of literature can become a motivational impulse to increase physical activity in the real world, moreover in the context of a very strong awareness of ethical values and moral behaviour.
Developmental motor problems and health‐related quality of life in 5‐year‐old children born extremely preterm: A European cohort study
Authors: Aubert Adrien M. , Costa Raquel , Johnson Samantha , Ådén Ulrika , Pierrat Véronique , Cuttini Marina , Männamaa Mairi , Sarrechia Iemke , Lebeer Jo , Van Heijst Arno F. , Maier Rolf F. , Sentenac Mariane , Zeitlin Jennifer ,   The SHIPS research group
Published: May 2023

AbstractAimTo measure the association between cerebral palsy (CP) and non‐CP‐related movement difficulties and health‐related quality of life (HRQoL) among 5‐year‐old children born extremely preterm (<28 weeks gestational age).MethodWe included 5‐year‐old children from a multi‐country, population‐based cohort of children born extremely preterm in 2011 to 2012 in 11 European countries (n = 1021). Children without CP were classified using the Movement Assessment Battery for Children, Second Edition as having significant movement difficulties (≤5th centile of standardized norms) or being at risk of movement difficulties (6th–15th centile). Parents reported on a clinical CP diagnosis and HRQoL using the Pediatric Quality of Life Inventory. Associations were assessed using linear and quantile regressions.ResultsCompared to children without movement difficulties, children at risk of movement difficulties, with significant movement difficulties, and CP had lower adjusted HRQoL total scores (β [95% confidence interval] = −5.0 [−7.7 to −2.3], −9.1 [−12.0 to −6.1], and − 26.1 [−31.0 to −21.2]). Quantile regression analyses showed similar decreases in HRQoL for all children with CP, whereas for children with non‐CP‐related movement difficulties, reductions in HRQoL were more pronounced at lower centiles.InterpretationCP and non‐CP‐related movement difficulties were associated with lower HRQoL, even for children with less severe difficulties. Heterogeneous associations for non‐CP‐related movement difficulties raise questions for research about mitigating and protective factors.
Social determinants of health for children with cerebral palsy and their families
Authors: Ostojic Katarina , Karem Isra , Paget Simon P. , Berg Alison , Dee‐Price Betty‐Jean , Lingam Raghu , Dale Russell C. , Eapen Valsamma , Woolfenden Sue ,   EPIC‐CP Group
Published: May 2023

AbstractSocial determinants of health (SDH) influence health and social outcomes in positive and negative ways. Understanding the impact of SDH on children with cerebral palsy (CP) is essential to improve health equity, optimize health outcomes, and support children with CP and their families to thrive in society. In this narrative review, we summarize the landscape of SDH impacting children with CP and their families worldwide. In high‐income countries, children from poorer neighbourhoods are more likely to have severe comorbidities, present with spastic bilateral CP, and report lower frequency of participation in community activities. In low‐ and middle‐income countries, socioeconomic disadvantage is associated with increased risk of malnutrition, living in poorer housing conditions, not having access to proper sanitation, and living below the poverty line. Low maternal education is associated with increased likelihood of the child with CP experiencing increased severity of gross motor and bimanual functioning challenges, and poorer academic performance. Lower parental education is also associated with reduced child autonomy. On the other hand, higher parental income is a protective factor, associated with greater diversity of participation in day‐to‐day activities. A better physical environment and better social support are associated with higher participation in daily activities. Clinicians, researchers, and the community should be aware of these key challenges and opportunities. Then adopt a range of approaches that target adverse SDH/social needs and foster positive SDH in the clinical setting.What this paper adds

Understanding how social determinants of health influence health and social outcomes is a critical step towards improving health equity and outcomes.
Approaches are required that target the impact of adverse SDH on access to health care for children with cerebral palsy and that work towards ensuring equity of access for all.
Equity market and the transmission channels of monetary policy: Before and after the zero lower bound
Authors: DaSilva Amadeu , Farka Mira 
Published: May 2023

AbstractWe examine the effectiveness of the interest rate channel and the credit channel of monetary policy before and after the zero lower bound (ZLB), using intraday stock returns. We construct a number of industry‐specific and firm‐specific indicators to capture the sensitivity of firms' demand to interest rates (interest rate channel) and firms' financial constraints (credit channel). We find that the transmission of monetary policy has shifted across both periods. Conventional monetary policy works through both the neoclassical interest rate channel and the credit channel, while unconventional policy is propagated primarily via the credit channel which became even more effective at the ZLB. Before the ZLB the transmission channels operate primarily through target rate shocks rather than forward guidance announcements, whereas both forward guidance and large scale asset purchases were equally important for the credit channel at the ZLB. We also find strong evidence that transmission channels are asymmetric depending on the state of the stock market (bull/bear, tighter/easier credit conditions, high/low volatility), and the type of policy surprises (positive/negative). Our findings are robust with respect to a number of model extensions and alternative specifications.
Hydrology is a major influence on amphibian abundance in a large European floodplain
Authors: Hamer Andrew J. , Czeglédi István , Gál Blanka , Sály Péter , Szalóky Zoltán , Preiszner Bálint , Erős Tibor 
Published: May 2023

Abstract

River–floodplain ecosystems play a crucial role in connecting landscape patches through hydrological connectivity, but they are among the most threatened ecosystems. Floodplains provide important habitat for amphibians by connecting aquatic and terrestrial habitats. Modifications to floodplain hydrology can impact amphibian communities, yet few studies have examined amphibian metacommunities in floodplain wetlands.

In this study, we assessed patterns in amphibian breeding abundance in one of the largest floodplains of the Danube River, Hungary, relative to hydrological connectivity and multi‐scale variables at 30 waterbody sites. Our aim was to determine whether these patterns aligned with the pond‐permanence gradient hypothesis, where breeding amphibian abundance is predicted to be highest in ephemeral ponds without large predatory fish. We used Bayesian hierarchical modelling to estimate multi‐species abundance from repeated survey (count) data collected over one breeding season.

We detected the eggs and larvae of four amphibian species. The best model of abundance included covariates describing two principal component axes associated with waterbody hydrology and landscape composition within a 500‐m radius of a site. There was a positive relationship between mean community abundance at a site and hydrological disconnection from the main river channel; however, the common toad (Bufo bufo) was associated with hydrologically connected waterbodies. There was a positive relationship between mean community abundance and a high proportion of forest cover and low cover of agricultural land within a 500‐m radius around a site, although this relationship was clear for only two species. There was no support for models containing the number of large predatory fish species detected at a site.

Although our results showed that amphibian abundance declined with hydrological connectivity, based on model selection we could not ascribe this relationship to an increased number of large predatory fish species detected in waterbodies close to the main river channel. Differences in life history and habitat requirements are likely to have explained interspecific responses to hydrological connectivity. Our results underscore the importance of addressing amphibian abundance at multiple spatial scales in floodplain wetlands, as landscape composition partly explained patterns in abundance.

Application of multi‐species abundance modelling allowed us to investigate environmental relationships for common and infrequently detected species. Habitat restoration programmes in floodplains should provide waterbodies disconnected from main river channels as potential amphibian breeding sites and protect or restore forest as terrestrial habitat.
Information sharing in the presence of retailer's risk aversion and altruism
Authors: Huang He , Li Wenping , Li Shiying , Xu Hongyan 
Published: May 2023

AbstractIn highly uncertain times, firms are increasingly exhibiting risk aversion to uncertain demand and altruism to supply chain partners to reduce risk and maintain stability. To deal with high demand fluctuations, numerous firms are adopting information‐sharing strategies. We study how a retailer's risk aversion and altruism affect her demand information‐sharing decision by constructing game‐theoretic models. We first show that information sharing makes double marginalization (DM) stronger and hurts the retailer and generates an information‐sharing DM effect. The retailer's risk aversion strengthens this effect, while her altruism weakens the effect. Meanwhile, information sharing generates an uncertainty reduction effect on the risk‐averse retailer by reducing volatility and an altruism improvement effect on the altruistic retailer by increasing the manufacturer's profit. Whether information sharing benefits the retailer depends on her level of risk aversion and altruism. The retailer prefers voluntary sharing when both her risk aversion and altruism are high.
Trade spends and profitability of promotions
Authors: Sinitsyn Maxim 
Published: May 2023

AbstractThis paper examines the prevalent mechanism of financing advertising and temporary price reductions through trade spend budgets. A manufacturer and a retailer interact for a number of periods with a plan to hold a sale in the last period. During the nonpromotional periods, the retailer accumulates the funds in this budget in proportion to the size of its order from the manufacturer. In the sale period, the budget is used to finance the discount offered by the manufacturer and advertising. I find that the manufacturer drops its price in the sale period to increase the profitability of promotions for the retailer. To be able to sell more units during the sale period, the retailer needs to accumulate a larger trade spend. This is accomplished by setting a smaller mark‐up over the manufacturer's price in the regular periods. The manufacturer takes advantage of the retailer's softer pricing by increasing its regular wholesale price. As long as such trade spends are used to finance advertising, the total profits of each firm increase. Using fixed trade spends, where the manufacturer allocates a fixed amount for the retailer, does not lead to an increase in profits.
Identification and validation of novel Blastocystis subtype ST41 in a Colombian patient undergoing colorectal cancer screening
Authors: Hernández‐Castro Carolina , Maloney Jenny G. , Agudelo‐López Sonia P. , Toro‐Londoño Miguel A. , Botero‐Garcés Jorge H. , Orozco María C. , Quintero‐Quinchia Yulieth C. , Correa‐Cote Juan C. , Múnera‐Duque Alejandro , Ricaurte‐Ciro Juan C. , Londoño‐Álvarez Luis I. , Escobar René M. , Köster Pamela C. , Sánchez Sergio , Carmena David , Santín Mónica 
Published: May 2023

AbstractBlastocystis sp. is among the most frequent intestinal protists identified in humans globally. However, characterization of Blastocystis subtype diversity in humans is ongoing. We report here the identification of novel Blastocystis subtype ST41 in a Colombian patient undergoing colorectal cancer screening involving colonoscopy and fecal testing (microscopy, culture, PCR). The full‐length ssu rRNA gene sequence of the protist was generated using MinION long‐read sequencing technology. The validity of the novel subtype was confirmed via phylogenetic and pairwise distance analyses of the full‐length ST41 sequence and all other valid subtypes. The study provides reference material essential for conducting subsequent experimental studies.
The Quality‐Weighted Matching Function: Did the German Labor Market Reforms Trade‐Off Efficiency against Job Quality?
Authors: GARTNER HERMANN , ROTHE THOMAS , WEBER ENZO 
Published: May 2023

AbstractWe evaluate the quantity–quality trade‐off on the labor market by estimating an augmented matching function weighting the matches by quality measures. We use the approach to evaluate the German labor market reforms conducted between 2003 and 2005. Indeed, we find a significant quantity–quality trade‐off. However, even after controlling for job quality, a good half of the positive effect of the reforms on matching efficiency remains.
Factors that help and hinder transgender and nonbinary youth accessing gender care in Ireland: A multistakeholder exploration
Authors: Kearns Seán , O'Shea Donal , Neff Karl 
Published: May 2023

AbstractIntroductionThe purpose of this study was to identify the common factors that help and hinder transgender and nonbinary youth accessing gender‐specific health care in Ireland and to identify how these factors may be perceived differently by young people seeking gender‐affirming care, their parents, and health‐care providers.DesignQualitative investigation utilizing framework analysis (FA).MethodsIn‐depth one–one interviews were conducted with transgender and nonbinary youth (n = 10), parents of youth (n = 10), and gender‐specific health‐care providers (n = 10). Maximum variation and snowball sampling were used to recruit participants across Ireland. An interview guide codesigned with an expert panel of gender‐diverse youth was utilized. Interviews were audio‐recorded and transcribed verbatim. FA was used to code the data and identify key issues and recommendations.ResultsFour themes were derived: (1) “Needing bricks to build” (structural factors); (2) “Enduring and convincing” (diagnostic factors); (3) “Being me, hiding me”; (personal factors); and (4) “It takes a tribe” (interpersonal factors). Each stakeholder group perceived different factors as help or hindrance in accessing care with varying intensities.ConclusionsParamount to the future of gender services in Ireland is the investment of resources for children and young adults. Assessment is likely to remain a component of gender care, but youth recommend distinct revisions to the assessment process. Additional research would be useful in exploring the intersection of neurodiversity and gender as it pertains to health‐care navigation. Family and peer support is a strong protective factor and enabler of health‐care access among youth.Clinical RelevanceAccess to gender‐specific health care remains difficult for transgender and non‐binary youth. An understanding of the complexity of this healthcare navigation by healthcare professionals may help to mitigate future negative experiences. This study explores some of the clinical considerations that arise for this population from provider perspectives while elucidating the experiences of youth and parents attempting to access care. Further research is needed on longitudinal outcomes following medical and surgical interventions for transgender youth, including nonbinary identities.
Noncompliant behaviors in general equilibrium: A survey
Authors: Bruno Chiarini , Maria Ferrara , Elisabetta Marzano 
Published: May 2023

AbstractThis paper reviews the literature on dynamic general equilibrium models that incorporate noncompliant behaviors. It organizes contributions according to selected dimensions that denote important pillars of the macroeconomic literature and that are relevant to explaining the nature and role of non‐compliant behaviors. These pillars are business cycles, macroeconomic policies, labor markets, income inequality, and financial factors. Starting with studies from the early 2000s, when general equilibrium models first began to include noncompliant behaviors, our study provides a temporal excursus on the evolution of the phenomenon in this literature.
Racial and income‐based affirmative action in higher education admissions: Lessons from the Brazilian experience
Authors: Zeidan Rodrigo , de Almeida Silvio Luiz , Bó Inácio , Lewis Neil 
Published: May 2023

AbstractThis survey article provides insights regarding the future of affirmative action by analyzing the implementation methods and the empirical evidence on the use of placement quotas in the Brazilian higher education system. All federal universities have required income and racial‐based quotas in Brazil since 2012. Affirmative action in federal universities is uniformly applied across the country, which makes evaluating its effects particularly valuable. Affirmative action improves the outcomes of targeted students. Specifically, race‐based quotas raise the share of Black students in federal universities, an effect not observed with income‐based quotas alone. Affirmative action has downstream positive consequences for labor market outcomes. The results suggest that income and race‐based quotas beneficiaries experience substantial long‐term welfare benefits. There is no evidence of mismatching or negative consequences for targeted students' peers.