bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heavy metals in street dust in Beijing, China: seasonal and spatial variations, pollution characteristics and health risk assessment
Authors: Chen Xinhao , Feng Haiyan , Guan Jian , Yu Xiangnan , Xue Fei , Yang Danyu 
Published: December 2022

Abstract
Street dust samples were collected from industrial, residential, educational, commercial, and park areas in Beijing, China, during spring and winter to investigate the contents of heavy metals (Cr, Ni, Cu, Zn, Pb, As, Cd and Hg) and evaluate the source apportionment and degree of environmental pollution according to the geo-accumulation index, ecological indices, and human health risk assessment. The average contents of eight heavy metals (mg/kg) in spring are as follows: Cr (98.17), Ni (26.38), Cu (67.33), Zn (394.87), Pb (64.39), As (6.32), Cd (0.618), and Hg (0.207). In winter they are Cr (94.54), Ni (26.13), Cu (73.03), Zn (341.73), Pb(73.09), As (7.66), Cd (0.635), and Hg (0.279). The rank order of heavy metals concentrations in functional areas is IA (Industrial area) >CA (Commercial area) >EA (Educational area) >RA(Residential area) >PA (Park area). The source apportionment analysis indicates that heavy metals in the street dust are mainly derived from mixed sources of natural, industrial and traffic-related source (54.64%). Both the geo-accumulation index and potential pollution index shows the pollution levels of different heavy metals in different functional areas: from unpolluted, moderately polluted to heavily polluted. A health risk assessment shows no non-carcinogenic and carcinogenic risk of heavy metals to children and adults. Among the five functional areas, the industrial area has the highest non-carcinogenic and carcinogenic risk compared to that of the others.
Translated consent documents rarely used in non-industry sponsored studies
Authors: Garon Edward , Velez Maria , Glenn Beth , Garcia-Jimenez Maria , Cummings Amy , Lisberg Aaron , Nanez Andrea , Radwan Yazeed , Lind-Lebuffe Jackson , Brodrick Paige , Li Debory , Fernandez-Turizo Maria , Gower Arjan , Lindenbaum Maggie , Hegde Manavi , Brook Jenny , Grogan Tristan , Elashoff David , Teitell Michael 
Published: December 2022

Abstract
Patients from historically underrepresented racial and ethnic groups are enrolled in cancer clinical trials at disproportionately low rates in the United States 1-3. As these patients often have limited English proficiency4-7, we hypothesized that one barrier to their inclusion is the cost to investigators of translating consent documents. To test this hypothesis, we evaluated more than twelve-thousand consent events at a large Cancer Center and assessed whether patients requiring translated consent documents would sign consent documents less frequently in studies lacking industry sponsorship (for which the principal investigator pays translation costs) than for industry sponsored studies (for which this cost is covered by the sponsor). Here, we show that the proportion of consent events for patients with limited English proficiency in studies not sponsored by industry was approximately half of that seen in industry sponsored studies. We also show that among those signing consent documents, the proportion of consent documents translated into the patient’s primary language in studies without industry sponsorship was approximately half of that seen in industry sponsored studies. Our results suggest that the cost of consent document translation in trials not sponsored by industry is a potentially modifiable barrier to the inclusion of patients with limited English proficiency.
Fluorescent in situ hybridization is a deceptive method for screening NRG1 gene rearrangements
Authors: Pu Xiaohong , Li Lin , Ren Shuang , Li Jing , Chen Jun , Fan Xiangshan , Peng Shuangshuang , Fu Yao , Zhang Qing , Ye Qing 
Published: December 2022

Abstract
Background
NRG1 rearrangement has been identified in many tumors and is considered an important treatment target. However, the prevalence of NRG1 fusion is extremely rare, and there are no universal testing algorithms for genetic testing.
Methods
A total of 3008 cases of various kinds of tumors were included in this study. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) were used to screen NTRK translocation and p-HER3 expression. FISH translocation or p-HER3 IHC-positive cases were further subjected to next-generation sequencing (NGS) testing.
Results
No cases were p-HER3 positive by IHC. Twenty-nine cases (0.96%, 29/3008) with NTRK translocation were found by FISH, and there were three different signal types: (A) break-apart signal (three cases) with or without a high copy number of the 3’-end of the gene; (B) low copy number of the 5’-end of the gene with respect to the 3’-end of the gene, with fusion signals (12 cases); and (C) low copy number of the 5’-end of the gene with respect to the 3’-end of the gene, without fusion signals. Through NGS, only eight of the 29 cases were confirmed to carry NRG1 fusion. The FISH type C group was completely consistent with the NGS results. For clinical characteristics, all of these NGS NRG1 fusion tumors were adenocarcinomas, and the majority of these tumors (7/8, 87.5%) were female. In addition to NRG1 fusion-enriched breast cancer and lung cancer, we also found cholangiocarcinoma and colorectal carcinoma with NRG1 fusion.
Conclusions
Although FISH is a deceptive method for screening NRG1 gene rearrangements, signals showed low copy number of the 5’-end of the gene with respect to the 3’-end of the gene, without fusion signals were reliable for NTRK fusions. Because of the high false negativity and high cost of NGS, FISH is still a good method for screening NRG1 fusions across cancers.
J-V Characteristics of Dark Current in Truncated Conical Quantum Dot Infrared Photodetectors (QDIPs)
Authors: Ali Nouran M. , El-Batawy Yasser M. 
Published: December 2022

Abstract
Quantum Dot Infrared Photodetector (QDIP) is one of the promising candidates for infrared photodetection due to its controllable heterojunction bandgap and sensitivity to normal incident radiation. It is expected to be superior to infrared photodetectors of mature technologies such as an HgCdTe or a quantum well infrared photodetector. In the presented paper, we have developed a theoretical model for the dark current in truncated conical QDIP as the truncated conical shaped QD structure is more appropriate to describe the fabricated dots. The dark current model is based on the drift diffusion model solving the main governing Poisson’s and continuity equations. In this model, the carrier mobility is calculated by solving time-dependent Boltzmann transport equation in the photodetector material with embedded truncated conical QDs using finite difference technique. The results of the developed model have been compared with the dark current characteristics with published experimental results of InAs/GaAs truncated QDIP. The effects of QD volume, QD aspect ratio and QD density and the operating temperature on the dark current characteristics have also been investigated.
COVID-19: Mental health consequences and strategies put in place to overcome them from the perspective of young adults experiencing social precarity and substance use in Montreal.
Authors: Lemaire Elise Cournoyer , Bertrand Karine , Aranda Jorge Flores , Batel Charlotte , Goyette Mathieu , Milot David-Martin , Jauffret-Roustide Marie , Wagner Vincent , Loignon Christine 
Published: December 2022

Abstract
This study explores the impact of the pandemic on mental health and the strategies put in place to overcome these challenges, from the perspective of young adults who experience social precarity and PS use in Montreal. This collaborative study used a descriptive qualitative design. Ten semi-directed interviews were conducted with young adults aged 18 to 30 years old who experience social precarity and PS use and were analysed thematically. Results demonstrate that participants experienced increased loneliness, psychological distress, and PS use resulting from the sanitary measures. They demonstrated capacities to rely on personal resources to promote harm reduction, resilience, self-entertainment, emotional and social support. The impacts of COVID-19 on mental health demonstrate the importance of maintaining and increasing psychosocial services’ offer in a pandemic context and to better adapt them to the realities of young adults, while also acknowledging and accounting for their strengths and capacities.
Replacement of Signalized Traffic Network Design with Hamiltonian Roads: Delay? Nevermind
Authors: Eriskin Ekinhan , TURKER Gul Fatma , GUNDUZ Fatih Kursat , Terzi Serdal 
Published: December 2022

Abstract
Signal optimisation is essential in traffic engineering. The traffic light control timings should be set as optimum. However, it is challenging because the traffic network is a non-polynomial problem. In this study, the problem is evaluated from a unique perspective. The primary idea is to remove the crossings of the intersections. A Hamiltonian cycle algorithm has been used to design the network. So, vehicles are only able to join or split. Thus, no control mechanism is needed that delays or interrupts the flow. The suggested algorithm and intersection design were tested on Allsop and Charlesworth's widely used sample network. Findings were compared with the literature in the form of delay calculated using the Highway Capacity Manual 2010 formula. The suggested network’s delay is calculated to be 98.17% and 95.45% less than the original network and recently published study-based delay, respectively. As a result, Hamiltonian roads seem sustainable in time and fuel consumption and could be used for future designs.
A study on spatio-temporal coordination and driving forces of urban land and water resources utilization efficiency in the Yangtze River Economic Belt
Authors: Li Zhenqiang , Guo Jiayao , You Xiaoyue 
Published: December 2022

Abstract
Using panel data from 11 provinces from 2003 to 2017 in the Yangtze River Economic Belt, the study explores the spatio-temporal differentiation characteristics and driving forces of coupling coordination of urban land and water resource utilization efficiency by constructing the coupling coordination model and the spatial econometric model. The results show that (1) in terms of time, the situation of inefficient utilization of urban land and water resources was severe. Spatially, the distribution of utilization efficiency of two resources was consistent with the pattern of regional economic development; (2) the coupling coordination degree of urban land and water resources utilization efficiency was mainly of mild disorder type and transitional type, and was in a gradient decreasing spatial distribution from downstream to midstream to the upstream region; (3) the coupling coordination degree of urban land and water resources utilization efficiency presented significantly positive spatial auto-correlation, but the agglomeration trend was weakening; (4) per capita GDP, employment labor force and fixed assets investment were important driving forces for the coordination development of urban land and water resources, while the role of government and the total population had a negative impact on it, and the driving role of the industrial structure had not yet been played.
A predictive model for ammonium removal in polishing ponds operated in sequential bath mode
Authors: de Morais Carlos Eduardo Pereira , dos Santos Silvânia Lucas , van Haandel Adrianus 
Published: December 2022

Abstract
The magnitude of pH changes in polishing ponds can be predicted by simple stoichiometric rules if the extent of processes affecting this parameter is known. Thus, the objective of this article was to develop a model that predicts pH variation and ammonia desorption in polishing ponds in sequential batches, depending on the rates of processes that affect pH in ponds and to evaluate the influence of temperature and depth on these processes. As the temperature conditions change during the year, for model validation, tests were carried out under two medium temperature conditions (hot period and cold period) and four lakes with depths between 0.2 and 1.0 m. The proposed model is validated by the good correspondence between the simulated and experimentally obtained values for the two temperature conditions and for both periods. For the hot period, the model excelled, presenting a high linear correlation, always with R 2 above 0.90 for all ponds. For the cold period, the lowest R 2 obtained was 0.74 for the four lakes. Thus, the proposed model is suitable to describe the pH variation and ammonia desorption in polishing ponds in sequential batches, at all analyzed depths and under both temperature conditions.
Recent Advances in Synthetic Strategies of Benzimidazole and its Analogs: A Review
Authors: Singh Himanshu , Kumar Rajnish , Tiwari Prashant , Singh Ayushi 
Published: December 2022

Abstract:
It has been established on the basis of reported research that benzimidazoles and their analogs are active scaffolds. Benzimidazole is a benzofused imidazole compound that is present in several marketed molecules with a wide range of uses that established its importance in pharmaceutical sectors and industry. Drugs with a benzimidazole nucleus have unique structural characteristics and an electron-rich environment that allows them to attach to a variety of physiologically significant sites and produce a variety of actions. The development of benzimidazole heterocyclic molecules as antihistaminic (H1-receptor antagonist, for example, bilastine; 5-HT3 antagonist, for example, leri-setron); antimicrobial (antibiotic, for example, ridinilazole); antiulcer (proton pump inhibitor (PPI), for example, ilaprazole); antihypertensive (calcium channel blocker, for example, mibefradil); and drugs used to treat cancer include those that are antiparasitic (specifically anthelmintic, such as fubendazole), antipsychotic (D2 receptor antagonist, such as clopimozide), analgesic (opioid analgesic, such as clonitazene), and phosphodiesterase inhibitor (PDE3 inhibitor, such as adibendan). Due to its broad applications, scientists are continuously enthralled by benzimidazoles and their derivatives to study their chemistry. Several synthesis strategies can prepare benzimidazole or its derivatives and the focus will always be on new, greener, and more economical ways for its synthesis. Among all methods, catalytic cyclization, catalytic coupling, and catalytic reactions are the most used approaches for the synthesis of benzimidazoles and their analogs. The present review entitled various synthetic approaches for synthesizing benzimidazole from 2009 to 2021 and its derivatives, which will be very useful to researchers for developing benzimidazole moieties.
Preliminary Study on Human Adipose Stem Cells Promoting Skin Wound
Healing through Notch Signaling Pathway
Authors: Wang Yi , Dong Mengjie , Zheng Yang , Wang Chao , Ding Xu , Wu Heming , Wu Yunong , Zhang Wei , Song Xiaomeng 
Published: December 2022

Background:
Mesenchymal stem cells (MSCs) have been documented as possible candidates for wound healing treatment because their use could reinforce the regenerative capacity of many tissues. Human adipose stem cells (hADSCs) have the advantages of easy access, large quantity and easy operation. They can be fully applied in the treatment of skin wounds.

Objective:
In this study, we aim to explore the roles and potential mechanisms of hADSCs in cutaneous wound healing.

Methods:
hADSCs were obtained from human subcutaneous fat. Adipocytes and osteocytes differentiated from hADSCs were determined by staining with Oil Red O and alkaline phosphatase (ALP), respectively. We assessed the effects of hADSCs and hADSC conditional medium (CM) on wound healing in an injury model of mice. Then, we investigated the biological effects of hADSCs on human keratinocytes HaCAT cells in vitro.

Results:
The results showed that hADSCs could be successfully differentiated into osteogenic and lipogenic cells. hADSCs and hADSCs-CM significantly promote skin wound healing in vivo. hADSCs significantly promoted HaCAT cell proliferation and migration by activating the Notch signaling pathway and activated the AKT signaling pathway by Rps6kb1 kinase in HaCAT cells. In addition, we found that hADSCs-mediated activation of Rps6kb1/AKT signaling was dependent on the Notch signaling pathway.

Conclusion:
We demonstrated that hADSCs can promote skin cell-HaCAT cell proliferation and migration via the Notch pathway, suggesting that hADSCs may provide an alternative therapeutic approach for the treatment of skin injury.
The Evolution of Pancreatic Islet Function in a Diabetic Patient after
Pancreatic Neuroendocrine Neoplasm Surgery: A Case Report
Authors: Zhou Ligang , Wen Song , Pan Junhong , Liu Congying , Yuan Xinlu , Wang Congcong , You Qinghua , Liu Xinjiang 
Published: December 2022

Background:
Pancreatic neuroendocrine neoplasms (pNENs) are rare primary tumors
of the pancreas. Although these tumors are heterogeneous and can be classified as functional or
non-functional according to pancreatic endocrine biomarkers, the more prevalent type is non-functional
pNENs with endocrine differentiation but with non-specific symptoms and often late diagnoses.
The treatment option for patients often involves surgical management, but the reported outcomes,
especially on insulin secretion change and the trend of diabetes in these patients, varied to
date. Hence, the purpose of this clinical report is to study the functional change of pancreatic β-
cell corresponding to the mass of tumorectomy of pNEN in a diabetic patient.

Case Presentation:
We reported that a 39-year-old man with diabetes was found complicated with
neuroendocrine neoplasm. He was admitted to the General Surgery of our hospital for further examination
and therapy. The patient received a pancreatectomy + splenectomy + lymphadenectomy
on the pancreatic body and tail. We analyzed the pancreatic mass change and performed Oral Glucose
Tolerance Test (OGTT) before and after the surgery to evaluate the function of the pancreas.

Conclusions:
This case may provide us a reference to predict the extent of islet function loss before
the pancreatectomy, and apply personalized hypoglycemic therapy after surgery in these patients.
Pengontrolan Nutrisi pada Sistem Tomat Hidroponik Menggunakan Kontroler PID
Authors: Akbar Faizal Beni , Muslim Muhammad Aziz , Purwanto Purwanto 
Published: December 2022

â€“ Sistem hidroponik merupakan sebuah metode bercocok tanam modern tanpa menggunakan media tanah melainkan air dengan menekankan pemenuhan kebutuhan nutrisi pada tanaman. Sistem Nutrient Film Technique (NFT) merupakan sistem yang mendukung dimana aliran air sangat dangkal mengandung semua nutrisi terlarut. Pengontrolan nutrisi pada sistem tomat hidroponik diperlukan, karena pertumbuhan tanaman bergantung pada pemberian nutrisi yang ideal. Pemberian nutrisi dapat dilihat dari kadar keasaman (pH) air tomat hidroponikÂ yang idealnya berkisar antara 5.5 hingga 6.5. Sedangkan, air hidroponik biasanya bersifat basa. Dengan menggunakan kontroler PID, sistem akan menghasilkan error steady state yang kecil dan akan mendapatkan settling time yang cepat. Proses perancangan kontroler PID dengan menggunakan metode Ziegler-Nichols didapatkan parameter PID dengan nilai parameter Kp = 4.26, Ki = 0.1065, dan Kd = 42.6. Dari hasil pengujian kontroler PID didapatkan settling time sebesar 520 detik dan recovery time sebesar 118 detik.Â
Assessing the impact of a virtual short-term study-abroad program on Japanese university students’ global-mindedness
Authors: Deacon Brad , Miles Richard 
Published: December 2022

Short-Term Study-Abroad (STSA) programs are popular in Japanese higher education; however, participating students’ experiences are under-researched, particularly in areas outside of second-language acquisition. This study empirically assessed the impact of a six-week study-abroad program with a US university (conducted online as a virtual program due to the COVID-19 pandemic) on sophomore Japanese university students’ Global-Mindedness (GM). This mixed-methods study employed experimental (n=53) and control (n=82) groups to investigate the following research question: What is the impact of a virtual STSA program on the GM of participating students? Quantitative data were collected at three time periods (pretest/posttest/post-posttest) using a modified version of the 30- item, five-factor GM Scale (GMS, see Hett, 1993). Descriptive statistics and two-way ANOVAanalyses revealed a significant increase in the experimental groups’ posttest results, which then returned to similar pretest levels in the post-posttest period. Reflection papers, surveys, and semi-structured interviews informed the qualitative perspective, and findings suggested a need for sustained post-program supportive measures to help maintain students’ GM.
Спонтанная эмиссия в утекающие моды нанопроводов
Authors: Николаев В.В. , Гиршова Е.И. , Калитеевский М.А. 
Published: December 2022

Получены алгебраические выражения для вероятности спонтанного излучения в утекающие моды для эмиттеров в нанопроводе, ориентированных радиально, аксиально и азимутально по отношению к оси нанопровода. Рассчитаны диаграммы направленности и зависимости вероятности спонтанной эмиссии от положения эмиттера. Показано, что при определенных значениях диаметра нанопровода вероятность спонтанной эмиссии на границе нанопровода может увеличиваться на порядок, и возможно формирование узкой диаграммы направленности. Ключевые слова: нанопровод, спонтанная эмиссия, утекающие моды.