bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Enlarged Perivascular Spaces in Reliable Distinction of Prospective Targeting During Deep Brain Stimulation in Patients With Advanced Parkinson's Disease: A Study of Deterministic and Probabilistic Tractography
Authors: Vedaei Faezeh , Fayed Islam , Alizadeh Mahdi , Miller Christopher , Zhang Ashley B. , Koa Victoria , Khan Suharto , Mohamed Feroze B. , Wu Chengyuan 
Published: April 2023

BACKGROUND:
Precise electrode position is vital for effective deep brain stimulation in treating motor symptoms in Parkinson's disease (PD). Enlarged perivascular spaces (PVSs) are associated with pathophysiology of neurodegenerative diseases including PD and may affect the microstructure of surrounding brain tissue.

OBJECTIVE:
To quantify the clinical implications of enlarged PVS on tractography-based stereotactic targeting in patients with advanced PD selected to undergo deep brain stimulation.

METHODS:
Twenty patients with PD underwent MRI scanning. The PVS areas were visualized and segmented. Based on the size of the PVS areas, the patient group was split into 2 categories of large vs small PVSs. Probabilistic and deterministic tractography methods were applied to a diffusion-weighted data set. Fiber assignment was performed using motor cortex as an initiation seed and the globus pallidus interna and subthalamic nucleus, separately, as inclusion masks. Two exclusion masks used consisted of cerebral peduncles and the PVS mask. The center of gravity of the tract density map was measured and compared between the tracts generated with and without consideration of the PVS mask.

RESULTS:
The average differences between the center of gravity of the tracts made by excluding PVS and without excluding PVS using deterministic and probabilistic tractography methods were less than 1 mm. Statistical analysis showed nonsignificant differences between deterministic and probabilistic methods and differences between patients with large and small PVSs (P > .05).

CONCLUSION:
This study demonstrated that the presence of enlarged PVS is unlikely to affect targeting of basal ganglia nuclei based on tractography.
A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone
Authors: Sigloch Christian , Spitz Dominik , Driever Wolfgang 
Published: April 2023

ABSTRACTNeural proliferation zones mediate brain growth and employ Delta/Notch signaling and HES/Her transcription factors to balance neural stem cell (NSC) maintenance with the generation of progenitors and neurons. We investigated Notch-dependency and function of her genes in the thalamic proliferation zone of zebrafish larvae. Nine Notch-dependent genes, her2, her4.1-4.5, her12, her15.1-15.2, and two Notch-independent genes, her6 and her9, are differentially expressed and define distinct NSC and progenitor populations. her6 prominently executes patterning information to maintain NSCs and the zona limitans intrathalamica Shh signaling activity. Surprisingly, simultaneous deletion of nine Notch-dependent her genes does not affect NSCs or progenitor formation, and her4 overexpression only caused reduction of ascl1b progenitors. Combined genetic manipulations of Notch-dependent and -independent her genes suggest that her6 in the thalamic proliferation zone prominently maintains NSCs and inhibits NSC-to-progenitor lineage transitions. The her gene network is characterized by redundant gene functions, with Notch-independent her genes better substituting for loss of Notch-dependent her genes than vice versa. Together, her gene regulatory feedback loops and cross-regulation contribute to the observed robustness of NSC maintenance.
THE SPECIAL ROLE OF THE LABOR MARKET AS A UNIVERSAL FACTOR OF PRODUCTION
Authors: Suvalova Tatyana , Ashurbekov R. , Zhuravleva O. , Suvalov O. 
Published: April 2023

In modern conditions of the economy, unstable financial and political processes, the labor market is undergoing serious changes on a global scale. The article discusses the demand and supply of labor, the impact of migration processes, unemployment rates, the dynamics of the domestic and international markets, both at the macroeconomic and microeconomic levels. A study of the labor market as an economic system is given, taking into account the indicators of GDP and GNI. The ratio of supply and demand in the labor market in macroeconomic theory is considered, the dependence of wages on working hours is given. Attention is focused on the analysis of the relationship between the labor market and the unemployment rate. The data on the unemployment rate for the constituent entities of the Russian Federation, indicators of the impact of the minimum wage and migration (immigration) on the labor market, the results of economic data on migration in the labor markets of the Migration Advisory Committee (MAC) are provided.
D-shaped photonic crystal fiber sensor based on the surface plasmon resonance effect for refractive index detection
Authors: Liu Xiaokai , Yuan Jinhui , Qu Yuwei , Zhang Jingao , Zhou Xian , Yan Binbin , Wang Kuiru , Sang Xinzhu , Yu Chongxiu 
Published: April 2023

In this paper, a photonic crystal fiber (PCF) sensor based on the surface plasmon resonance (SPR) effect for refractive index (RI) detection is proposed. We design a D-shaped polished PCF structure consisting of air holes arranged in a hexagonal lattice. The silver film is coated on the middle channel of the polished surface of the PCF. The finite element method is used to analyze the propagation characteristics of the proposed D-shaped SPR-PCF sensor. Simulation results show that the proposed D-shaped SPR-PCF sensor has a maximum wavelength sensitivity of 30,000 nm/RIU, an average wavelength sensitivity of 6785.71 nm/RIU, and a maximum resolution of 3.33×10−6RIU in the RI range of 1.22–1.36. Owing to the high wavelength sensitivity in the considered RI range, the proposed D-shaped SPR-PCF sensor is suitable for applications in water contamination detection, liquid concentration measurement, food safety monitoring, etc.
Prevalence of Sarcopenia in Liver Cirrhosis: A Systematic Review and Meta-Analysis
Authors: Mazeaud Simon , Zupo Roberta , Couret Alexis , Panza Francesco , Sardone Rodolfo , Castellana Fabio 
Published: April 2023

ABSTRACT

Introduction:
Chronic liver disease (CLD) is often combined with a morbidity burden that strongly affects the functional domain. In liver cirrhosis (LC), qualitative and quantitative muscle wasting, known as sarcopenia, poses an added clinical burden, together with co-morbidities and a poor quality of life.

Methods:
We conducted a systematic review and meta-analysis of the prevalence of sarcopenia in LC. The literature was screened through six electronic databases from the study's inception to January 2023. No exclusion criteria were applied to language, operative tools for diagnosing sarcopenia, population age, general health status, country, and study setting (cohort or cross-sectional). Two independent researchers applied the inclusion criteria in parallel to evaluate the eligibility of the 44 retrieved articles; only 36 met the eligibility requirements, reporting 36 prevalence entries on sarcopenia in LC.

Results:
The total sample (N=8821) was slightly dominated by males (N=4941). The cross-sectional design predominated over the longitudinal, and the hospital setting was prevalent. The pooled prevalence of sarcopenia across the selected studies was 33% (95% CI 0.32-0.34), with high heterogeneity (I

2
=96%). A further meta-analysis using the Child-Pugh (CP) score to stage LC was conducted on 24 entries, and the results showed that for the LC populations classified with the CP-A, CP-B, and CP-C staging, respectively, the overall mean prevalence was 28% (95%CI 0.26-0.29), 27% (95%CI 0.25-0.29), and 30% (95%CI 0.27-0.29). The risk of bias was moderate. In LC, one in three patients suffers sarcopenia.

Discussion:
Poor management of muscle mass loss plays a role in the prognosis of death and quality of life of LC patients. Clinicians in the field are recommended, when screening for sarcopenia, to pay close attention by carefully assessing body composition as part of the monitoring scheme.
Ein Jahr Erstcheck NS-Raubgut für Öffentliche Bibliotheken
Authors: Köhler Norman 
Published: April 2023

Abstract
The article presents the two-year research project “Initial check Nazi-looted materials in public libraries” / „Erstcheck NS-Raubgut für Öffentliche Bibliotheken“, which aims to examine and assess the old collections of participating public libraries from eight German states regarding Nazi-looted materials. The findings obtained during the first year of work on the research project will be outlined.
Improved diagnostics of purine and pyrimidine metabolism disorders using LC-MS/MS and its clinical application
Authors: Cremonesi Alessio , Meili David , Rassi Anahita , Poms Martin , Tavazzi Barbara , Škopová Václava , Häberle Johannes , Zikánová Marie , Hersberger Martin 
Published: April 2023

Abstract

Objectives
To develop a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantify 41 different purine and pyrimidine (PuPy) metabolites in human urine to allow detection of most known disorders in this metabolic pathway and to determine reference intervals.

Methods
Urine samples were diluted with an aqueous buffer to minimize ion suppression. For detection and quantification, liquid chromatography was combined with electrospray ionization, tandem mass spectrometry and multiple reaction monitoring. Transitions and instrument settings were established to quantify 41 analytes and nine stable-isotope-labeled internal standards (IS).

Results
The established method is precise (intra-day CV: 1.4–6.3%; inter-day CV: 1.3–15.2%), accurate (95.2% external quality control results within ±2 SD and 99.0% within ±3 SD; analyte recoveries: 61–121%), sensitive and has a broad dynamic range to quantify normal and pathological metabolite concentrations within one run. All analytes except aminoimidazole ribonucleoside (AIr) are stable before, during and after sample preparation. Moreover, analytes are not affected by five cycles of freeze-thawing (variation: −5.6 to 7.4%), are stable in thymol (variation: −8.4 to 12.9%) and the lithogenic metabolites also in HCl conserved urine. Age-dependent reference intervals from 3,368 urine samples were determined and used to diagnose 11 new patients within 7 years (total performed tests: 4,206).

Conclusions
The presented method and reference intervals enable the quantification of 41 metabolites and the potential diagnosis of up to 25 disorders of PuPy metabolism.
Efficacy of bronchoscopic intratumoral injection of endostar and cisplatin in lung squamous cell carcinoma patients underwent conventional chemoradiotherapy
Authors: Ji Yanzhen , Luan Shuli , Yang Xiaoping , Yin Bin , Jin Xiaojie , Wang Haiyan , Jiang Wenqing 
Published: April 2023

Abstract
Bronchoscopy has been widely used for the therapy of lung cancer. This study aimed to evaluate the therapeutic efficacy and adverse reactions of bronchoscopic intratumoral injection of endostar and cisplatin in patients with lung squamous cell carcinoma (LSCC). A total of 40 LSCC patients who underwent conventional chemoradiotherapy were included in this study, and 20 of them received a bronchoscopic injection of endostar and cisplatin as an additive therapeutic modality (treatment group). The clinical response rate, progression-free survival (PFS), and adverse reactions of the patients were compared and analyzed. The treatment group had better short- and long-term therapeutic efficacy compared to the control group, but no significant differences were observed between the two therapeutic regimens in adverse reactions. Elderly and advanced LSCC patients had worse therapeutic efficacy and a high probability of adverse reactions after the therapy. Collectively, our analysis data demonstrated that the bronchoscopic intratumoral injection of endostar and cisplatin had improved therapeutic efficacy, and the cardiovascular adverse reactions were within the controllable range in the treatment of LSCC in clinical practices.
Silencing of long noncoding RNA MIAT inhibits the viability and proliferation of breast cancer cells by promoting miR-378a-5p expression
Authors: Yan Chao , Jin Yue 
Published: April 2023

Abstract
Myocardial infarction–associated transcript (MIAT) is a long noncoding RNA that plays a critical role in a variety of diseases. Accordingly, this study probed into the possible interaction mechanism between MIAT and miR-378a-5p in breast cancer. Concretely, MIAT and miR-378a-5p expressions in breast cancer tissues and cells were measured. After transfection with siMIAT and miR-378a-5p inhibitor, the viability and proliferation of breast cancer cells were examined by cell counting kit-8 and colony formation assays. The expressions of apoptosis-related proteins were detected. According to the results, MIAT was highly expressed in breast cancer tissues and cells. MIAT silencing could decrease Bcl-2 expression, viability, and proliferation of breast cancer cells and increase the expressions of cleaved caspase-3 and Bax. MIAT and miR-378a-5p could directly bind to each other, and MIAT silencing promoted the expression of miR-378a-5p. miR-378a-5p expression was low in breast cancer tissues. The miR-378a-5p inhibitor enhanced the viability and proliferation of breast cancer cells and partially reversed the effects of MIAT silencing on the breast cancer cells. In conclusion, MIAT silencing inhibits the viability and proliferation of breast cancer cells by promoting miR-378a-5p, indicating the potential of MIAT as a new target for the treatment of breast cancer.
Russlands bataillonstaktische Gruppen in der operativen Planung und im taktischen Einsatz im Krieg um die Ukraine 2014 bis 2023
Authors: Reisner Markus , Hahn Christian 
Published: April 2023

Kurzfassung
Im Rahmen ihres 2008 gestarteten Modernisierungsprogramms haben die russischen Heeresverbände starkes Gewicht auf bataillonstaktische Gruppen (BTG) gelegt. Diese erschienen besonders geeignet für den Einsatz in lokalen und kleinen Kriegen und fanden erstmals Einsatz im Ukraine-Konflikt 2014. Nach den Erfahrungen aus diesem sowie dem Syrien-Konflikt wurden Organisation und Einsatz der BTGs erheblich verbessert. Im Zuge des russischen Angriffskriegs vom Februar 2022 maß Russland der Rolle von BTGs hohe Bedeutung zu, was sich offensichtlich als Irrtum erwies. Dieser Beitrag analysiert die verschiedenen Kriegsphasen und zeigt auf, wie wenig der BTG-Ansatz Russland geholfen hat, seine Kriegsziele zu erreichen, und welche Faktoren für den Ausgang dieses Kriegs bestimmend sein werden.
Investigation of stepped microbeam vibration motions according to modified couple stress theory
Authors: Polat Sırrı Can , Bağdatlı Süleyman Murat 
Published: April 2023

Abstract
In this study, linear and nonlinear vibration movements of simply supported stepped microbeams placed in a magnetic field have been analyzed using Modified Couple Stress Theory. By taking into account the step radius ratio, step-change position, and material size parameter, the equations of motion of the stepped-microbeam are obtained using the Hamilton principle. The resulting equations of motion are nondimensionalized to eliminate dependence on material type and geometric structure. The approximate solution of the dimensionless equations of motion is calculated using the method of multiple scales, one of the perturbation methods. The solution stages of the study are divided into two separate parts as linear and nonlinear problems. Firstly, the linear issue of the stepped microbeam is addressed. The natural frequencies of the system are derived by solving the linear problem. Linear and nonlinear effects of step radius ratio, step-change position, and microbeam coefficient are investigated and frequency-amplitude graphs are presented. The resonance state where forcing frequency is equal to natural frequency is examined and stability analysis has been made.
RESEÑA/REPORT DIÁLOGOS POSDIGITALES LAS TRIC COMO MEDIOS PARA LA TRASFORMACIÓN SOCIAL
Authors: Gascón Vera Patricia 
Published: April 2023

Es el tiempo del humanismo. En la era postdigital, donde las inteligencias artificiales conquistan espacios hasta ahora humanos, la apuesta por las inteligencias múltiples que solo son resultado del estudio y el fomento de las relaciones, es indispensable.
Con esta premisa, los valedores del término TRIC, aquel que difiere del modelo instrumentalista TIC por la R del Factor Relacional, Carmen Marta-Lazo y José Antonio Gabelas-Barroso publican en sus diálogos posdigitales la adaptación de este constructo a las nuevas fórmulas. Aquellas que ejecutan desde el transmedia los medios y entremedios sobre los que ayudan a reenfocar su modelo de relación para la transformación social.
Spit It Out: Is Caffeine Mouth Rinse an Effective Ergogenic Aid? A Systematic Review and Meta-Analysis
Authors: Nabuco Lara Lima , Mendes Guilherme Falcão , Barreto Gabriel , Saunders Bryan , Reis Caio Eduardo Gonçalves 
Published: April 2023

ABSTRACT
The effects of caffeine mouth rinse (Caff-MR) on sports performance have been evaluated by recent studies presenting contrasting results. Therefore, this systematic review aimed to summarize the evidence regarding the effects of Caff-MR on sports performance. According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations, the search through PubMed, Web of Science, and Scopus databases was performed until December 2021. A random-effects meta-analysis of standardized mean differences was performed to assess the overall effect of Caff-MR on sports performance-related outcomes. Sixteen studies met the inclusion criteria (207 participants). The meta-analysis showed no significant overall effect of Caff-MR on sports performance (p = 0.09). Moreover, no effects were shown on maximal heart rate or ratings of perceived exertion. The risk of bias for the included studies assessed using the risk of bias in randomized trials Cochrane tool presented 87.5% (n = 14) of the studies as medium and 12.5% (n = 2) as high scores. These data do not support using Caff-MR for sports performance, although more consistent and well-controlled studies are warranted. Large heterogeneity in study designs precludes making practical recommendations for exercise performance. More research is warranted to elucidate the potential of Caff-MR, specifically focusing on determining the optimal dose.
The mitochondrial ribosomal protein mRpL4 regulates Notch signaling
Authors: Mo Dongqing , Liu Chenglin , Chen Yao , Cheng Xinkai , Shen Jie , Zhao Long , Zhang Junzheng 
Published: April 2023

AbstractMitochondrial ribosomal proteins (MRPs) assemble as specialized ribosome to synthesize mtDNA‐encoded proteins, which are essential for mitochondrial bioenergetic and metabolic processes. MRPs are required for fundamental cellular activities during animal development, but their roles beyond mitochondrial protein translation are poorly understood. Here, we report a conserved role of the mitochondrial ribosomal protein L4 (mRpL4) in Notch signaling. Genetic analyses demonstrate that mRpL4 is required in the Notch signal‐receiving cells to permit target gene transcription during Drosophila wing development. We find that mRpL4 physically and genetically interacts with the WD40 repeat protein wap and activates the transcription of Notch signaling targets. We show that human mRpL4 is capable of replacing fly mRpL4 during wing development. Furthermore, knockout of mRpL4 in zebrafish leads to downregulated expression of Notch signaling components. Thus, we have discovered a previously unknown function of mRpL4 during animal development.
Addressing Child Mental Health Inequities Through Parental Mental Health and Preschool Attendance
Authors: Goldfeld Sharon , Moreno-Betancur Margarita , Gray Sarah , Guo Shuaijun , Downes Marnie , O’Connor Elodie , Azpitarte Francisco , Badland Hannah , Redmond Gerry , Williams Katrina , Woolfenden Sue , Mensah Fiona , O’Connor Meredith 
Published: April 2023

BACKGROUND
Prevention is key to reducing socioeconomic inequities in children’s mental health problems, especially given limited availability and accessibility of services. We investigated the potential to reduce inequities for disadvantaged children by improving parental mental health and preschool attendance in early childhood.

METHODS
Data from the nationally representative birth cohort, Longitudinal Study of Australian Children (N = 5107, commenced in 2004), were used to examine the impact of socioeconomic disadvantage (0–1 year) on children’s mental health problems (10–11 years). Using an interventional effects approach, we estimated the extent to which inequities could be reduced by improving disadvantaged children’s parental mental health (4–5 years) and their preschool attendance (4–5 years).

RESULTS
Disadvantaged children had a higher prevalence of elevated mental health symptoms (32.8%) compared with their nondisadvantaged peers (18.7%): confounder-adjusted difference in prevalence is 11.6% (95% confidence interval: 7.7% to 15.4%). Improving disadvantaged children’s parental mental health and their preschool attendance to the level of their nondisadvantaged peers could reduce 6.5% and 0.3% of socioeconomic differences in children’s mental health problems, respectively (equivalent to 0.8% and 0.04% absolute reductions). If these interventions were delivered in combination, a 10.8% (95% confidence interval: 6.9% to 14.7%) higher prevalence of elevated symptoms would remain for disadvantaged children.

CONCLUSIONS
Targeted policy interventions that improve parental mental health and preschool attendance for disadvantaged children are potential opportunities to reduce socioeconomic inequities in children’s mental health problems. Such interventions should be considered within a broader, sustained, and multipronged approach that includes addressing socioeconomic disadvantage itself.
Coseismic Slip Model of the 19 September 2022 Mw 7.6 Michoacán, Mexico, Earthquake: A Quasi-Repeat of the 1973 Mw 7.6 Rupture
Authors: Liu Chengli , Lay Thorne , Bai Yefei , He Ping , Xiong Xiong 
Published: April 2023

AbstractOn 19 September 2022, a major earthquake struck the northwestern Michoacán segment along the Mexican subduction zone. A slip model is obtained that satisfactorily explains geodetic, teleseismic, and tsunami observations of the 2022 event. The preferred model has a compact large-slip patch that extends up-dip and northwestward from the hypocenter and directly overlaps a 1973 Mw 7.6 rupture. Slip is concentrated offshore and below the coast at depths from 10 to 30 km with a peak value of ∼2.9 m, and there is no detected coseismic slip near the trench. The total seismic moment is 3.1×1020  N·m (Mw 7.6), 72% of which is concentrated in the first 30 s. Most aftershocks are distributed in an up-dip area of the mainshock that has small coseismic slip, suggesting near-complete strain release in the large-slip patch. Teleseismic P waveforms of the 2022 and 1973 earthquakes are similar in duration and complexity with high cross-correlation coefficients of 0.68–0.98 for long P to PP signal time windows, indicating that the 2022 earthquake is a quasi-repeat of the 1973 earthquake, possibly indicating persistent frictional properties. Both the events produced more complex P waveforms than comparable size events along Guerrero and Oaxaca, reflecting differences in patchy locking of the Mexican megathrust.