bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Challenge and Hindrance Work Stressors on Work Well-being Among Chinese Policemen: Mechanism and Boundary Condition
Authors: Cai Lun , Xu Xizheng , Miao Qiaoling , Deng Jue 
Published: January 2025

Abstract

Background: The impact of work stressors on work well-being has been a focal point of research, however, the findings to date have exhibited a degree of inconsistency.
Methods: This study investigated the impact of two types of work stressors, namely, challenge work stressors and hindrance work stressors on the work well-being of Chinese police officers based on Cognitive-Transactional Theory. A total of 693 officers participated by completing assessments of work stressors, work well-being, coping strategies, and perceived social support.
Results: The results showed the following: (1) both types of work stressors significantly influence work well-being, with coping strategies mediating this relationship; (2) positive coping strategy mediates the positive relation between challenge work stressors and work well-being; (3) negative coping strategy mediates the negative relation between hindrance work stressors and work well-being; (4) on the one hand, perceived social support enhanced the positive relation between positive coping strategy and work well-being, on the other hand, perceived social support buffered the negative relation between negative coping strategy and work well-being.
Conclusion: These results highlight the complex mechanisms linking work stressors to work well-being in the policing profession and offer practical insights for designing targeted stress management interventions for law enforcement personnel.
Orbital Apex Syndrome in Noninvasive Fungal Rhinosinusitis: a case report
Authors: Yin Zhongju , Hu Xiaoyan , Liu Shuang , jiang liang 
Published: January 2025

Abstract

Background
Orbital apex syndrome (OAS) is characterized by multiple cranial nerve involvement leading to orbital pain or headache, vision loss, and ptosis. Typical clinical features are attributed to various tumors, vascular, infection, or sinus inflammatory diseases involving the orbital apex. Therefore, understanding the etiology of orbital tip syndrome and early identification and rapid treatment may help reduce related comorbidities.
Case presentation
We report the case of a 44-year-old Chinese female patient who presented with occipital headache, pain in the left eye, and sudden loss of vision in the left eye. Left orbital apex syndrome was diagnosed. The pain and ptosis worsened after glucocorticoid anti-inflammatory therapy and insulin control of blood glucose. CT scan was completed to consider the mass of the left sphenoid sinus, orbital apex, nasopharynx, and pterygopalatine fossa without excluding the possibility of tumor. In terms of treatment, functional endoscopic sinus surgery was performed. Headache, ptosis and pain disappeared at the latest follow-up 3 months after surgery, but left vision and ptosis did not improve significantly.
Conlusion
In showing the specific diagnosis and treatment process of this case, we should strengthen interdisciplinary knowledge and cooperation to prevent misdiagnosis. Early identification and prompt treatment of the cause of the orbital tip syndrome.
Methamphetamine exposure during the preweaning period alters hippocampal neurogenesis
Authors: Čechová Barbora , Patková Kristýna , Fišerová Ivana , Vaculín Šimon , Šlamberová Romana 
Published: January 2025

Abstract

Background: Methamphetamine (MA) is one of the most abused illicit drugs in the world. Abuse of this drug among adolescents, given the still-developing physiological functions of the body, including the central nervous system (CNS), is problematic. The hippocampus (HP) is part of the limbic system and is associated with cognition, as well as the reward system, which is mediated by dopamine (DA). Disruption of this system is the primary mechanism underlying addiction and results in cognition deficiencies.
Methods: In this work, we focused on the influence of MA on the development of the rat HP during postnatal days 11–20. Subsequently, after MA application, we studied learning and memory processes using the Morris Water Maze (MWM). After the MWM, we measured the expression of the protein doublecortin (DCX), neurotransmitter levels of DA, GLU, 5HT, NA, and GABA, and glial fibrillary acidic protein (GFAP).
Results: MA significantly impairs HP neurogenesis when administered during the third postnatal week, as indicated by reduced expression of DCX, which correlates with increased levels of glial fibrillary acidic protein (GFAP), but these changes were not significantly reflected in learning abilities and memory formation nor the levels of neurotransmitters.
Conclusion: We speculate that these mechanisms must be strongly expressed on multiple molecular levels to be able to cause cognitive changes. A significant role in this process is associated with the ability of young organisms to compensate and, to a certain extent, neurotoxic effects.
The association of PD-L1 expression status and PD-1/PD-L1 inhibitors-related toxicities profile in non-small cell lung cancer
Authors: Zhu Qian , Hu Hao , OuYang Li-Ying , Yang Rong , Wei Wen-Xiao , Huang Pin , He Xin-Rong 
Published: January 2025

Abstract

Purpose
PD-L1 expression has been explored to guide the treatment options for programmed cell death 1 and its ligand (PD-1/PD-L1) inhibitors-based therapy in non-small cell lung cancer (NSCLC), but the association of its treatments-related toxicities profile with PD-L1 expression status is unclear. To make the optimized and personalized use of such agents, we performed current study.
Experimental Design
: Multiple databases (Cochrane Library, EMBASE, and PubMed databases) from inception to June 30, 2024 were retrieved to search PD-1/PD-L1 inhibitors-related clinical trials of NSCLC that had described data regarding treatment-related adverse events (TRAEs) and PD-L1 expression.
Results
Twenty-six trials, involving 5,453 patients, were eligible for final analysis. PD-L1-positive patients suffered a higher frequency of AEs leading to discontinuation, and grade 3–4 treatment-related adverse events (TRAEs) compared with PD-L1-negative patients at most cut-off value. However, the frequency of all-grade TRAEs, SAEs, and FAEs showed numerically difference among PD-L1-positive and PD-L1-negative patients at most cut-off value. Different PD-1/PD-L1 inhibitors type did not detect a consistent dose-dependent pattern between PD-L1-positive and toxicities profile. Subgroup analyses noted that patients using 22C3 immunohistochemistry assay have a higher frequency of all-grade TRAEs. Moreover, patients receiving first-line therapy and those enrolled in open-label trials experienced a higher frequency of grade 3–4 TRAEs.
Conclusions
We suggested that clinicians, and patients should be informed of the association of PD-L1 expression status and toxicities profile prior to PD-1/PD-L1 inhibitors administration.
Optimized MPR Selection in OLSR routing protocol for UAV Communications in Public Safety applications
Authors: Hicham HAMEURLAINE , Mehallegue Noureddine , Benssalah Mustapha 
Published: January 2025

Abstract

Unmanned Aerial Vehicle Ad-hoc Networks (UANETs) are vital in disaster scenarios, providing reliable communication for life-saving operations despite challenges such as rapid changes in network topology and energy constraints that can lead to link instability. Although current enhancements to the Optimized Link State Routing (OLSR) protocol focus on real-time metrics, they often struggle to adapt to dynamic conditions, revealing a significant limitation. In response to this challenge, we present an optimized OLSR protocol that effectively integrates real-time metrics such as congestion, node position, and energy levels with predictive metrics, including estimated node lifetime and movement direction, within the Multi-Point Relay (MPR) selection process. This approach enhances network stability and extends operational lifespan by proactively avoiding unstable links before disruptions occur. Our analysis demonstrates that the proposed protocol outperforms existing OLSR-based solutions, achieving improved average throughput, higher Packet DeliveryRatios (PDR), and extended node lifespans across various conditions, including both sparse and dense networks, as well as low and high mobility scenarios.
Robust recognition of circular coded markers with relaxed constraints on multiple features
Authors: Zheng Maoteng , Lu Xingyue , Zhang Yingying 
Published: January 2025

Abstract

Coded marker recognition is a significant task in computer vision and photogrammetry communities. Existing methods are only available for high-quality images, and perform poorly on images with large viewing angles, low resolutions, and unevenly distributed intensities. To this end, we design a circular coded markers based on Schneider’s algorithm and propose a robust method for its recognition on degraded images. The global images are divided into sub-images in prior to image binarization to avoid contour disappearance, which usually occurs in the binarization of the global image with unevenly distributed intensities, and then the coded marker borders are extracted in the sub-images. After that, the images inside the borders are re-binarized for extracting high-quality contours; and the concept of relaxed constraints on multiple features is applied to filter out false contours. Finally, the geometric center is located and the encrypted information is decoded based on the identified contours. The proposed method is extensively evaluated and compared with the state-of-the-art methods (the original Schneider’s and ArUco algorithms). Preliminary results demonstrate the superiority of the proposed method over the baselines regarding the recognition rates on degraded images.
A Non-Uniform and Optimized Clustering Mechanism to Improve Network Lifetime in 5g-Based Indoor Localization
Authors: Nagamani Vadala , Annapurna K. 
Published: January 2025

Abstract

High-accuracy localizationis considered critical for resource management algorithms in modern applications such Internet of Things (IoT), smart factories, and autonomous vehicles. Indoor positioning presents a challenging process as the complexity of attaining higher accuracy is difficult within the indoor environments.This paper proposes a novel Non-Uniform and Optimised Clustering Mechanism (NUOCM) for indoor localization to manage complex datasets acquired from large-scale indoor radio systems. Using NUOCM-based communication, the research aims to improve the network lifetime and serves a reasonable number of User Equipments (UEs) or devices in Multiple Input Multiple Output (MIMO) systems. NUOCM generates clusters through a novel method that uses an ensemble of classifiers from non-uniform cluster layers in 5G-based indoor localization.The UEs or devices are divided into sub-datasets based on values of Reference Signal Received Power (RSRP). Base classifiers including Support Vector Machine (SVM), Artificial Neural Network (ANN), Decision Tree (DT), and Random Forest (RF)are trained on these non-uniform clusters across several layers to improve spatial diversity. Finally, the optimal number of layers and clusters are defined by a Firefly Algorithm (FA), which maximises for localization accuracy, spatial diversity. The experiments are evaluate the efficacy of the proposed NUOCM and the results show an increased localization accuracy and network lifetime than the traditional clustering techniques in MIMO systems.
Genome-wide identification of circular RNAs to elucidate the genetic basis of disease resistance to Salmonella infection in Chicken
Authors: Khan Mahak , Dar Mashooq Ahmad , Nazir Junaid , Bhat Sahar Saleem , Haq Zulfqarul , Shabir Nadeem , Bhat Hina Fayaz , Shah Riaz A. , Ahmad Sheikh F. , Al-Mazoura Haneen A. , Bhat Basharat , Ahmad Syed Mudasir 
Published: January 2025

Abstract

Salmonella infections have far-reaching implications for public health due to their potential to cause various human illnesses, ranging from gastroenteritis to more severe conditions like enteric fever. These infections are predominantly food-borne and are often linked to consuming contaminated meat products, with poultry being a common transmission source. Consequently, Salmonellosis ranks among the most prevalent food-borne illnesses, leading to substantial morbidity, hospitalizations, and even fatalities. In this study, we investigated the role of circular RNAs (circRNAs) in mediating the response to Salmonella Typhimurium infection in poultry, focusing on two chicken breeds: broiler (Cobb 430) (susceptible) and Kashmir Faverolla (resistant). Through high-throughput RNA sequencing, we identified and analyzed circRNA expression patterns in liver and spleen samples from both breeds. Results reveal a comprehensive catalog of circRNAs, with 26 differentially expressed (DE) circRNAs identified across various comparison groups. Our study revealed that the circRNAs associated with genes conferring resistance to Kashmir Faverolla are predominantly located on chromosome 1, with a notable presence also observed on chromosome 4. Moreover, genes FGB, FGG, and ALB could play pivotal roles in mediating the response to Salmonella infection in poultry. Network analyses and protein-protein interaction networks shed light on the interconnectedness of genes like FGB, FGG, and ALB, suggesting their collaborative roles in mediating the response to Salmonella infection. Moreover, functional analyses uncover significant biological processes associated with target mRNAs, emphasizing their involvement in immune responses, infectious diseases, and molecular pathways. Keywords: Circular RNA; Salmonella; Infection; Chicken; Disease resistance.
Performance Evaluation of FBMC with optimal subcarrier spacing for 5G &amp; beyond Communications
Authors: Padmavathi T , Cheepurupalli Kusma Kumari , Madhu R 
Published: January 2025

Abstract

In 5G New Radio (NR) Release 15, the 3rd Generation Partnership Project (3GPP) Physical Layer Modulation for downlink and uplink communications, the Cyclic Prefix OFDM (CP-OFDM) is used. A wide range of potential use cases will describe future wireless networks. In order to achieve this, time-frequency resources must be dynamically assigned, which is difficult for traditional Orthogonal Frequency Division Multiplexing (OFDM). Therefore, OFDM improvements like filtering or windowing are needed. On the other hand, a multicarrier method like Filter Bank Multi-Carrier (FBMC) can be employed. Several prototype filters, including Hermite, PHYDYAS, and Root Raise Cosine (RRC), are used in this work to develop the framework for FBMC. Time-frequency efficiency will be determined for each user in the same band by adjusting the subcarrier spacing. The performance of the Signal to Interference Noise Ratio (SIR) is calculated for FBMC using varying subcarrier spacing and compared with different multicarrier transmission methods such as f-OFDM (filtered OFDM), CP-OFDM, UFMC (Universal Filter Multi Carrier), Weighted Overlap and Add (WOLA). FBMC outperforms among all these multi carrier modulations and proven that it is suitable even for low latency transmissions.
Subsequent Cancers following Non-myeloablative Conditioning for Allogeneic Hematopoietic Cell Transplantation
Authors: Vo Phuong , Ng Kevin , Schoch H. Gary , Cooper Jason , Vupalanchi Abhishek , Flowers Mary , Sandmaier Brenda , Gooley Ted , Storb Rainer 
Published: January 2025

Abstract

We examined the risk of subsequent malignant neoplasms (SMNs) in 1720 patients with hematologic cancers given allogeneic hematopoietic grafts from 03/1998 to 08/2023 after nonmyeloablative conditioning regimens. With a median follow-up of 12 years, the cumulative incidence of SMNs was 17% (95% CI, [15%, 19%]). Most SMNs (n = 543) were non-melanoma skin cancers seen in 208 patients; unfortunately, information on these cancers was not available in the Surveillance, Epidemiology, and End Results (SEER) database for comparison with such tumors in the general population. However, developing non-melanoma skin cancers was statistically significantly associated with chronic GVHD and, thus, unlikely to be conditioning regimen related. Eighty-six patients (5%) developed 93 other SMNs. This number (93 SNMs) significantly exceeded the expected 73.4 cases in the comparison group (p = 0.03). This increase was driven exclusively by increases in uterine adenocarcinoma (n = 2), squamous lip cancer (n = 5), and squamous penile cancer (n = 2); the latter two cancers were, again, associated with chronic GVHD. Apart from these three tumor types, there were no observed increases in the risk of other tumors compared to those in the general population.
Neurenteric Cyst of the Intradural Extramedullary Region of the Cervical Spine: A Case Report
Authors: Mehrizi Mohammad Ali Abouei , Hashemi Narges , Sedaghat Mehran , Najafi Neshat Najaf , Eshaghzade Azin 
Published: January 2025

Abstract

Introduction:
Neurenteric cysts (NCs), also known as endodermal cysts, are rare congenital lesions of endodermal origin. They were thought to originate from a failure of dissolution of the neurenteric canal between the notochord and endoderm during the third week of embryogenesis. The primary clinical symptoms differ from focal pain to paresthesia and weakness based on the cyst's location. Here we present a case of intradural extramedullary NC of the spine at the cervical level.
Case presentation:
A 10-year-old boy presented with neck pain and weakness in his left hand. Imaging studies revealed fusion of cervical vertebrae at the levels of C3-C4 and C5-C6. On MRI, a cystic lesion in the intradural extramedullary region compressing the cord was evident. Surgical total resection, as the preferred treatment option, was done through the posterior approach, and the definitive diagnosis was made based on the histochemical analysis.
Conclusion
NC is a rare lesion and should be kept in mind as a differential diagnosis. Surgical intervention, particularly total resection, commonly improves the sensory and motor deficits associated with NC and is the treatment of choice.
Association of depressive symptoms with quality of life and treatment efficacy in patients with intermediate or advanced hepatocellular carcinoma receiving immunotherapy: A prospective cohort study
Authors: Lu Fei-Chen , Li Fan-Rong , Zhao Feng-Juan , Huo Rong-Rui , You Xue-Mei 
Published: January 2025

Abstract

Background
Depression is prevalent among individuals with cancer. This prospective cohort study aims to examine the relationships between depressive symptoms and both quality of life (QoL) and treatment efficacy in patients with intermediate or advanced hepatocellular carcinoma (HCC) who are receiving immunotherapy.
Methods
A cohort of 156 patients with intermediate or advanced HCC who were receiving immunotherapy was included in the analysis. Depressive symptoms were evaluated utilizing the Patient Health Questionnaire-9 (PHQ-9). The primary outcome was progression-free survival (PFS), whereas the secondary outcomes were the objective response rate (ORR), disease control rate (DCR), overall survival (OS), and QoL.
Results
Nearly half (48.7%) of the patients exhibited depressive symptoms. Over a median follow-up period of 10 months, patients with depressive symptoms had significantly lower PFS (HR 4.31, 95% CI: 2.75–6.76) and significantly shorter OS (HR 5.39, 95% CI: 1.84–15.82). Furthermore, the ORR and DCR were notably lower in patients with depressive symptoms (ORR 10.5% compared with 37.5%; DCR 52.6% compared with 91.2%). QoL scores were significantly lower at all assessed time points for patients with depressive symptoms, indicating worse overall well-being.
Conclusions
Depression is significantly associated with the efficacy of immunotherapy in HCC patients and is negatively associated with both clinical outcomes and QoL. Addressing mental health is essential for optimizing treatment strategies and improving overall patient outcomes in this population.
RGS14 binding to GNAI3 regulates human SSC proliferation and apoptosis through PLPP2, and abnormalities in these genes are associated with azoospermia
Authors: Zhou Dai , Liu Bang , Liu Lvjun , peng Lin , Liu Xiaowen , Zhu Fang , Deng Aimin , Zhang Shusheng , Mao Zenghui 
Published: January 2025

Abstract

Background
Non-obstructive azoospermia (NOA) is a severe form of male infertility characterized by the absence of sperm in the ejaculate due to impaired spermatogenesis. Spermatogonial stem cells (SSCs) play a crucial role in maintaining male fertility by ensuring continuous sperm production. However, the molecular mechanisms regulating SSC fate and their involvement in NOA remain largely unknown.
Results
In this study, we utilized single-cell RNA sequencing to analyze gene expression profiles in normal and NOA testes, revealing a significant downregulation of RGS14 in SSCs of NOA patients. We found that RGS14 interacts with GNAI3 and modulates SSC proliferation and apoptosis by regulating the expression of PLPP2 and the MAPK signaling pathway. Knockdown of RGS14 significantly inhibited SSC proliferation and increased apoptosis, effects that were partially rescued by overexpression of PLPP2. Additionally, both PLPP2 and GNAI3 were found to be significantly downregulated in NOA patients, correlating with the expression pattern of RGS14.
Conclusions
Our findings provide novel insights into the molecular mechanisms underlying SSC dysfunction in NOA. The dysregulation of RGS14, GNAI3, and PLPP2 may contribute to the pathogenesis of NOA. These results not only elucidate the role of RGS14 in SSC fate determination but also identify potential therapeutic targets for male infertility.
Association of urinary cadmium with renal injury biomarkers and optimal cut-off value of urinary cadmium in preschool children from mining area of northwestern China
Authors: Balajiang Gulipiyan , Du Yue , Yuan Wenzheng , Xie Jingru , Zhao Wenting , Ai Shiwei , Dang Yuhui 
Published: January 2025

Abstract

Children demonstrate increased sensitivity and vulnerability to cadmium exposure compared to adults. Current research predominantly focuses on adults residing in cadmium-contaminated areas, while studies involving children remain relatively scarce. This study aimed to explore the relationship between urinary cadmium (U-Cd) and biomarkers of renal injury, identify sensitive biomarkers associated with cadmium-related renal injury, and evaluate the optimal cut-off value for U-Cd in preschool children. Morning urine samples were collected to detect urinalysis, U-Cd, and renal injury biomarkers, including urinary N-acetyl-β-D-glucosidase (UNAG), urinary β2-microglobulin (Uβ2-MG), and urinary retinol-binding protein (URBP). Pearson correlation, quantile regression, and logistic regression models were utilized to explore the relationships between U-Cd and the renal injury biomarkers. Receiver operating characteristic (ROC) curves were employed to determine the optimal cut-off value of U-Cd for inducing abnormalities in renal injury biomarkers. U-Cd demonstrated positive associations with UNAG, Uβ2-MG, and URBP. The optimal cut-off values of U-Cd for inducing abnormalities in UNAG, Uβ2-MG, URBP, and combined biomarker were 7.78, 14.74, 12.75, and 10.42 µg/g cr, respectively. When the sensitivity was set at 95%, the cut-off values were adjusted to 4.70, 10.42, 11.07, and 5.18 µg/g cr, respectively. U-Cd was significantly associated with renal injury biomarkers. Our findings suggest that the appropriate cut-off value for U-Cd should be established based on the sensitivity and specificity of various renal injury biomarkers.