bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caregiver burden and related determinants of adult patients with β- thalassemia major in mainland China
Authors: Zhang Shuo , Zhang Runqi , Ming Jing , Xie Jing , Liu Baoguo , Jiang Weihang , Fu Yingjie , Zhen Xuemei , Sun Xiaojie 
Published: May 2023

Abstract
Purpose The caregivers of adult patients with β-thalassemia major bear not only physical but also emotional and economic pressures of providing care. The aim of this study was to examine the determinants of caregiver burden in adult patients with β-thalassemia major in mainland China.
Methods In this cross-sectional study, we conducted an online survey with snowball sampling covering seven provinces between September 1, 2021, and January 31, 2022, of patients aged ≥18 years with β-thalassemia major and their caregivers. Caregiver burden was assessed using the Zarit Burden Interview (ZBI). Data on patient demographics, disease and therapy characteristics, and caregivers’ demographic characteristics were collected and analyzed using independent t-tests, analysis of variance, and multiple linear regression.
Results Of 75 included patients, more than half (50.7%) were male. The mean patient age was 24.69±5.59 years. The mean age of the caregivers was 50.60±9.16 years, with women (74.7%) being predominant. The ZBI score was 38.00 ±17.02. Multiple linear regression analysis showed that patients with interrupted blood transfusion therapy and caregivers required to care of others were positively associated with caregiver burden (p<0.05). Married caregivers were negatively associated with caregiver burden (p<0.05).
Conclusions The caregivers of adult patients with β-thalassemia major in mainland China experienced a moderate-to-severe level of caregiving burden. The burden was higher in patients with a history of interrupted blood transfusion therapy or in caregivers caring for others. Additionally, married caregivers experienced lower burdens compared to non-married caregivers. These findings provide a reference to identify caregivers with higher burdens among patients with β-thalassemia major.
A Novel CircRNA Circ_0001722 Regulates Proliferation and Invasion of Osteosarcoma Cells Through Targeting miR-204-5p/RUNX2 Axis
Authors: Gong Shuai , Zhang Yi , Pang Lina , Wang Liye , He Wei 
Published: May 2023

Abstract
Background
Osteosarcoma (OS) is the most prevalent primary fatal bone neoplasm in adolescents and children owing to limited therapeutic methods. Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the roles of circRNAs in OS are still unclear.
Methods
Firstly, we evaluate the differentially expressed circRNAs in 3 paired OS and corresponding adjacent nontumor tissue samples by circRNA microarray assay, finding a novel circRNA, circ_001722, significantly upregulated in OS tissues and cells. The circular structure of candidate circRNA was confirmed through Sanger sequencing, divergent primer PCR, and RNase R treatments. Proliferation of OS cells was evaluated in vitro and in vivo. The microRNA (miRNA) sponge mechanism of circRNAs was verified by dual-luciferase assay and RNA immunoprecipitation assay.
Results
A novel circRNA, circ_001722, is significantly upregulated in OS tissues and cells. Downregulation of circ_0001722 can suppress proliferation and invasion of human OS cells in vitro and in vivo. Computational algorithms predict miR-204-5p can bind with circ_0001722 and RUNX2 mRNA 3’UTR, which is verified by Dual-luciferase assay and RNA immunoprecipitation assay. Further functional experiments show that circ_0001722 competitively binds to miR-204-5p and prevents it to decrease the level of RUNX2, which upregulates proliferation and invasion of human OS cells.
Conclusion
Circ_001722 is a novel tumor promotor in OS, and promotes the progression of OS via miR-204-5p/RUNX2 axis.
Biomechanical investigation of traditional and modified cortical bone trajectory for osteoporosis lumbar spine - finite element analysis
Authors: Zhou Zhihao , Maimaiti Abulikemu , Kahaer Alafate , Tuoheti Abudusalamu , Wang Yixi , Xiao Yang , Liu Dongshan , Guo Hailong , Rexiti Paerhati 
Published: May 2023

Abstract
Background We aimed to investigate the biomechanical properties of the cortical bone trajectory (CBT) and modified cortical bone trajectory (MCBT) on the osteoporotic lumbar spine with the finite element method.Methods Four osteoporotic specimens were selected to establish the L4 vertebral body model. For the CBT, a screw with a diameter of 6.0 mm and a length of 35 mm was used, while for the MCBT, a screw with a diameter of 4.5 mm and a length of 40 mm was used. Two screws with different trajectories were inserted into the pedicles on the different sides of the same vertebral body. The axial pull-out strength, stability of the screw, and the stability of the vertebral body were compared.Results The pull-out strength of the MCBT (1620.00 ± 40.67N) was significantly higher than CBT (1360.25 ± 44.70N) (p < 0.001), and the stability of the MCBT screws in the upper, lower, left, and right direction was significantly higher than the CBT (p = 0.043; p = 0.027; p = 0.023; p = 0.035). The stability of the vertebral body with MCBT in axial rotation, and lateral bending was significantly higher than CBT (p = 0.005; p = 0.011). However, there was no significant difference in flexion and extension between the two groups (p > 0.05).Conclusion MCBT might be a choice for internal fixation of the lumbar spine in patients with osteoporosis.
Increased Risk of COVID-19 Infection Among Individuals with Periodontal Disease
Authors: Andrews Michael , Datta Santanu , Gao Hanzhi , Katz Joseph 
Published: May 2023

Abstract
Objectives Periodontal disease has been linked to multiple systemic conditions but the relationship with COVID-19 still needs to be elucidated. We hypothesized that periodontal diseases may be associated with Covid 19 infectionMaterials/Methods: This study utilized cross-sectional data to establish the strength of association between periodontal disease and COVID-19 infection. The University of Florida Health Center’s i2b2 patient’s registry was used to generate patient counts through ICD-10 diagnostic codes. Univariate descriptive statistics of the patient population and logistic regression to estimate odds ratios of associations between periodontal disease and COVID-19 infection were used for analysis.Results Patients with diagnosed periodontal disease were 4.4 times more likely to be positively diagnosed with COVID-19 than patients without periodontal disease. Associations remained similar and robust (P value < 0.0001) after adjustment for age (OR = 4.34; 95% CI, 3.68–5.09), gender (OR = 4.46; 95% CI, 3.79–5.23), and smoking status (OR = 4.77; 95% CI, 4.04–5.59). Associations were smaller but remained robust (P value < 0.0001) after adjusting for race (OR = 2.83; 95% CI, 2.40–3.32), obesity (OR = 2.53; 95% CI, 2.14–2.98), diabetes (OR = 3.32; 95% CI, 2.81–3.90), and cardiovascular disease (OR = 2.68; 95% CI, 2.27–3.14).Conclusions Periodontal disease is significantly associated with increased risk for COVID-19 infection.Clinical Relevance: With the caveat of a cross sectional study design, these results suggest that periodontal disease may increase the risk for Covid 19 infection.
The serum lipid profiles in immune thrombocytopenia: mendelian randomization analysis and a retrospective study
Authors: Xu Pengcheng , Zhao Yajing , Hou Ming , Xu Miao 
Published: May 2023

Abstract
Background Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by increased platelet destruction and impaired thrombopoiesis. Platelet indices changes depending on the morphology and volume of platelets. Serum lipids have been found to affect platelet formation and activity in certain diseases, thus induce the corresponding variation of platelet indices.Methods Mendelian randomization (MR) analysis was performed based on databases. The clinical data from 457 ITP patients were retrospectively collected and analyzed, including platelet indices, serum lipids, hemorrhage and therapeutic response.Results MR analysis showed low high-density-lipoprotein-cholesterol (HDL-C), low apolipoprotein A-1, high triglyceride (TG) and high apolipoprotein B (ApoB) causing high platelet distribution width (PDW); high low-density-lipoprotein-cholesterol (LDL-C) increasing mean platelet volume (MPV). In ITP, there were positive correlations between platelet count with TG, PDW with HDL-C and ApoB, and plateletcrit with TG and non-esterified fatty acid, and the correlation had gender differences. Bleeding scores were negatively corelated with cholesterol and LDL-C. LDL-C and homocysteine were risk factors for therapeutic response.Conclusions Serum lipids, especially cholesterol were tightly correlated with platelet indices, hemorrhage and therapeutic effects in ITP patients. These results provide clinical references for the management of serum lipids, and highlight the necessity to further explore the relationship between lipids and pathogenesis of ITP.Trial registration: No: NCT05095896, October 14, 2021, retrospectively registered.
Development of Interface Haze after Femtosecond Laser-assisted in situ Keratomileusis with Accelerated Corneal Crosslinking: a Case Series
Authors: Yin Hongbo , Wang Lixiang , Ma Ke 
Published: May 2023

Abstract
Background: Femtosecond laser-assisted in situ keratomileusis (FS-LASIK) with accelerated corneal crosslinking (FS-LASIK Xtra) is a recent procedure to achieve safer corneal ablation in myopic patients with borderline corneal thickness. Despite its well-accepted effectiveness, the development of remarkable interface haze is a potential concern but has rarely been reported and discussed.
Case presentation: we report for the first time a case series of 11 eyes of 7 patients who developed typical interface haze 1-3 months after FS-LASIK Xtra for the correction of myopia with astigmatism, with intensity grades ranging from 0.5+ to 3+ at the time of onset. Their preclinical spherical diopters ranged from -2.25 D to -9.25 D and cylindrical diopters ranged from -0.25 D to -2.50 D. The haze tended to be self-limiting, and topical anti-inflammatory therapy were given to moderate and severe cases, who responded well to treatment.
Conclusion: The development of clinically significant interface haze is a relatively rare complication after FS-LASIK Xtra but tends to have a higher incidence and intensity compared to conventional stromal surgery such as FS-LASIK. Timely treatment and close follow-up are essential to patients undertaking FS-LASIK Xtra.
Mobile Health Supported Multi-Domain Recovery Trajectories After Major Arthroplasty or Spine Surgery: A Feasibility Study
Authors: Naik Bhiken I. , Durieux Marcel E. , Dillingham Rebecca , Waldman Ava Lena , Holstege Margaret , Arbab Zunaira , Tsang Siny , Cui Quanjun , Li Xudong Joshua , Singla Anuj , Yen Chun-Po , Dunn Lauren K. 
Published: May 2023

Abstract
Background
Recovery after surgery intersects the physical, psychological, and social domain. Predicting and early identification of deviations from these multi-domain recovery pathways can facilitate personalized postoperative management and reduce complications. In this study our aims were to assess the feasibility of a mobile health application called PositiveTrends to collect multi-domain data after hip, knee arthroplasty or spine surgery and track procedure-specific, multi-domain recovery trajectories.
Methods
Prospective, observational study in participants greater than eighteen years of age. Data was collected prior to and up to one hundred and eighty days after completion of surgery within the functional, psycho-social, pain and medication usage domains using PositiveTrends. Generalized linear mixed effects models were used to estimate the change in the outcomes over time. Heat maps and effect plots were used to visualize the recovery trajectories. Participants provided quantitative and qualitative evaluation of the PositiveTrends platform.
Results
Forty-two participants were enrolled over a four-month recruitment period. Function improved by 8 and 6.4 points per month after hip and knee arthroplasty, respectively. In spine participants, the Oswestry Disability Index decreased by 1.4 units per month. Mood improved in all three cohorts, however stress levels remained elevated in spine participants. Social support remained stable in all groups. Pain decreased by 0.16 (95% Confidence Interval: 0.20, 0.13), 0.25 (0.30, 0.20) and 0.14 (0.15, 0.12) units per month in hip, knee, and spine cohorts respectively. The odds of using no medication increased for each month postoperatively. There was a 10.9-to-40.3-fold increase in the probability of using no medication for each month postoperatively. Mixed-methods analysis demonstrated high app usability scores and acceptability of PositiveTrends by participants.
Conclusions
In this feasibility study we demonstrate the utility of a mobile health platform to map and track multi-domain recovery trajectories after major arthroplasty or spine surgery.
Older adults' perceptions of physical activity in the urban neighborhood
Authors: khanizadeh sahar , Ehsani Mohammad , Ghaedrahmati Safar , Hosseini Rasool Norouzi Seyed , Yoon Young Jin 
Published: May 2023

Abstract
This paper aimed to explore the different dimensions in understanding the neighborhood environment from the perspective of the elderly and to describe their opinions in performing physical activity in a neighborhood environment in Tehran. Ekhtiarieh neighborhood in District Three in the city of Tehran was selected as the context of the study. The purposive sampling method was used to select the participants who were all older adults engaging in physical activities (PA) directly or indirectly in the neighborhood environment. In-depth interviews were employed to learn more about older adults' perceptions of physical activity in the neighborhood. For spatial assessment, each interviewee was asked to draw a map of their community to determine the locations, routes, and boundaries of physical activity and meaningful destinations in the neighborhood. The results indicated that city nodes in neighborhood environments were very effective points in physical activity. These nodes included shopping centers, green spaces, neighborhood parks, and playgrounds in the neighborhood. The analysis of the data indicated the health of the active elderly and the sense of place and emotions as main themes.
On Hermite-Hadamard-type characterizations of higher-order differential inequalities
Authors: Jleli Mohamed , Samet Bessem 
Published: May 2023

Abstract
Let $I$ be an open interval of $\mathbb{R}$ and $f: I\to \mathbb{R}$. It is well-known that $f$ is convex in $I$ if and only if, for all $x,y\in I$ with $x
Unmasked immune reconstitution inflammatory syndrome towards B-cell non-Hodgkin lymphoma during treatment of esophageal actinomycosis in a patient with advanced HIV: a case report
Authors: Vargas-Garcia Elsa K. , Fernandez-Aristi Augusto R. , Cornejo-Venegas Gonzalo , Montenegro-Idrogo Juan José , Chirinos-Vega Juan , Chiappe-Gonzalez Alfredo 
Published: May 2023

Abstract
Background Actinomycosis is an unusual chronic bacterial infection, even rarer in people living with HIV. It is not considered an AIDS-defining disease. However, the role in co-presentation or overlap with other opportunistic conditions of advanced HIV is unknown.Case presentation: A 49-year-old Peruvian male presented with a 4-month history of dysphagia, odynophagia, hyporexia and wasting. He underwent an upper digestive endoscopy, in which ulcers with a necrotic center were observed, therefore, the initial diagnostic assumption was esophageal cancer. Subsequent pathology report excluded neoplasms and confirmed the diagnosis of actinomycosis. Serology for human immunodeficiency virus was requested, yielding a positive result. Antimicrobial treatment with amoxicillin and antiretroviral therapy were indicated, with slow clinical improvement. After 4 months, epigastric discomfort presented, for which a new upper digestive endoscopy was performed, revealing a deep gastric ulcer, which was compatible with diffuse large B-cell non-Hodgkin lymphoma.Conclusion Esophageal actinomycosis in people living with HIV is very rare. We suggest HIV-associated immunosuppression is not enough to allow for actinomycosis to develop, and masked underlying entities should be sought. The existence of such entities in people living with HIV should raise awareness of the possibility of unmasked immune reconstitution inflammatory syndrome once treatment has started.
Study on grinding performance during ultrasonic vibration-assisted grinding ultra-high strength steels
Authors: Han Ming , Tang Yi , DING Wen-Feng , Zhao Junshuai , Zhao Biao , Liu Guoliang , Deng Mingming , Tang Menglan 
Published: May 2023

Abstract
Super high-strength steel has an important demand in manufacturing key components inside gear transmission systems of heavy-duty helicopter owing to its superior comprehensive mechanical property. However, the high-performance machining of super high-strength steel is confronted with great challenges owing to the high cutting force, serious tool wear, and impoverished machining quality. Comparative trials in grinding ultra-high strength steel under conventional grinding (CG) and ultrasonic vibration-assisted grinding (UVAG) processes was conducted with white alumina (WA) and microcrystalline alumina (MA) wheels. Grinding performances, including grinding forces, force ratio, ground surface quality, and abrasive wheel morphologies were discussed in detail. Experimental results show that the separation property between wheels and workpiece in UVAG process contributes to alter the material removal process, reducing the chip clogging and adhesion. In addition, the micro-fracture of abrasive grains can effectively improve the self-sharpening ability of abrasive wheels. UVAG possesses a shorter grinding scratch owing to the ultrasonic vibration than that of CG, which is beneficial to improve machining quality under the same wheel. Meanwhile, in comparison of WA wheels, MA wheels have the narrower grinding marks and better surface quality, which is due to the sharp edges produced by its higher strength, toughness and excellent self-sharpening.
Maximising Information Diffusion with Source and Locality Awareness
Authors: Gupta Yayati , Sukhija Sanatan , Kumar Rithic 
Published: May 2023

Abstract

The paper proposes a generalised framework for budgeted influence maximization. We propose a novel cost function that considers the potential seed nodes' properties as well as the firm interested in maximizing the influence. A greedy algorithm, maximizing the influence to cost ratio, is then used to select a balanced set of seed nodes. A local proxy is proposed to quantify the influence of nodes. We also show that the edge weights play an important role in determining the influential power of nodes. Further, the edge weights for a network can be efficiently predicted with the help of link prediction heuristics like resource allocation metrics and the Adamic-Adar index.
Sense of public medical fairness and influencing factors based on data of the Chinese Social Survey (CSS) (2017–2019)
Authors: Duan Shengnan , Yang Jie , Yu Huaxin , lv Zixuan , Ding Tong , Hao Zhe , Yuan Ni , Li Huihua 
Published: May 2023

Abstract
Background: The objective of this study was to have a better view of the sense and influencing factors of public medical fairness from the public perspective, which would provide objective evidence for decision-makers to facilitate the improvement of a multi-tiered medical security system.
Methods: This study was based on data from the Chinese Social Survey (CSS) in 2015, 2017, and 2019; the CSS is a cross-sectional survey in China. Indicators of social-demographic characteristics were included as independent variables, while evaluation of public medical care, which we named as “sense of public medical fairness”, was selected as the dependent variable. Data were analyzed using descriptive statistics, Chi-square test, analysis of variance (ANOVA), and multi-class logistic regression.
Results: The study revealed that, from 2015 to 2019, the sense of public medical fairness significantly increased (F=64.473, P<0.0001) and there was a significant move toward the direction of “very fair” of the radar map (P<0.0001). In 2015, there was positive correlation between internet use and sense of public medical fariness, however internet usage became negative impact on the evaluation of sense of public medical fairness. Security such as pension insurance or pension, medical insurance or public medical care, maternity insurance, unemployment insurance, injury insurance and subsistence allowance are playing increasing roles in the evaluation of sense of public medical fairness and most of them had protective effect on sense of public medical fairness.
Conclusion: Policy makers should promote the transformation of medical and health services in the digital era and explore and guide the positive impact of digital society on the development of medical and health services to enhance citizens' sense of fairness.
Analyzing Inter-Connected Processes: Using Object-Centric Process Mining to Analyze Procurement Processes
Authors: Berti Alessandro , Jessen Urszula , Park Gyunam , Rafiei Majid , Aalst Wil M.P. van der 
Published: May 2023

Abstract
The Purchase-to-Pay (P2P) process is one of the core business processes in any organization. It ensures the correct and efficient provisioning of materials and services.
An efficient P2P process reduces operational costs by ensuring discounts, avoiding late payments, and choosing the optimal supplier for the goods.
Process mining techniques help practitioners optimize the execution of P2P processes by analyzing the execution data and providing useful insights.
However, existing techniques may result in misleading insights due to many-to-many relationships between business objects (for example, between orders and invoices in the P2P process).
Recently, object-centric process mining techniques have been proposed to avoid the limitations of traditional process mining techniques.
In this paper, we present a case study on a real-life P2P process using object-centric process mining techniques.
To that end, we adopt the well-known PM$^{2}$ process mining project methodology to the object-centric setting and analyze the performance and compliance.
Evaluation of Strength Characteristics of Miscellaneous Fill Foundation
Authors: Guo Tong , Kong Dezhi , Wang Xin , Yu Yang , Zhang Jilu 
Published: May 2023

Abstract
The structure of miscellaneous fill foundation is complex. The determination of its mechanical properties and parameters is of great significance to engineering construction. This paper takes the miscellaneous fill foundation in Zhengzhou Rongchuang Xinmi Yinji North Project as an example, and the consolidated drained test is carried out on miscellaneous fill soil samples under the action of various confining pressures. The experimental results reveal that the mechanical factors of the soil sample are almost similar to those of the silty sand, and its stress-strain relationship follows the hyperbolic relationship for monotonic loading. Based on the nonlinear elastic constitutive model, the bulk modulus is also introduced to obtain the tangent deformation modulus and tangent Poisson's ratio under the action of monotonic loading. In continuing, an appropriate nonlinear elastic constitutive relation of the miscellaneous fill is established, and the experimental test method is employed to assess the model parameters. The analysis of the obtained results indicates that the initial modulus of various fill increases with the growing depth, and the tangential deformation modulus lessens with increasing load. The initial Poisson's ratio reduces with increasing depth, and the tangential Poisson's ratio grows with increasing load.