bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti–PD-1 Immunotherapy in Fibrotic Tumors
Authors: Akiyama Takahiko , Yasuda Tadahito , Uchihara Tomoyuki , Yasuda-Yoshihara Noriko , Tan Benjy J.Y. , Yonemura Atsuko , Semba Takashi , Yamasaki Juntaro , Komohara Yoshihiro , Ohnishi Koji , Wei Feng , Fu Lingfeng , Zhang Jun , Kitamura Fumimasa , Yamashita Kohei , Eto Kojiro , Iwagami Shiro , Tsukamoto Hirotake , Umemoto Terumasa , Masuda Mari , Nagano Osamu , Satou Yorifumi , Saya Hideyuki , Tan Patrick , Baba Hideo , Ishimoto Takatsugu 
Published: December 2022

AbstractExcess stroma and cancer-associated fibroblasts (CAF) enhance cancer progression and facilitate immune evasion. Insights into the mechanisms by which the stroma manipulates the immune microenvironment could help improve cancer treatment. Here, we aimed to elucidate potential approaches for stromal reprogramming and improved cancer immunotherapy. Platelet-derived growth factor C (PDGFC) and D expression were significantly associated with a poor prognosis in patients with gastric cancer, and PDGF receptor beta (PDGFRβ) was predominantly expressed in diffuse-type gastric cancer stroma. CAFs stimulated with PDGFs exhibited markedly increased expression of CXCL1, CXCL3, CXCL5, and CXCL8, which are involved in polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) recruitment. Fibrotic gastric cancer xenograft tumors exhibited increased PMN-MDSC accumulation and decreased lymphocyte infiltration, as well as resistance to anti–PD-1. Single-cell RNA sequencing and spatial transcriptomics revealed that PDGFRα/β blockade reversed the immunosuppressive microenvironment through stromal modification. Finally, combining PDGFRα/β blockade and anti–PD-1 treatment synergistically suppressed the growth of fibrotic tumors. These findings highlight the impact of stromal reprogramming on immune reactivation and the potential for combined immunotherapy for patients with fibrotic cancer.Significance:Stromal targeting with PDGFRα/β dual blockade reverses the immunosuppressive microenvironment and enhances the efficacy of immune checkpoint inhibitors in fibrotic cancer.See related commentary by Tauriello, p. 655
Comparação entre o polimorfismo do gene Apoe na composição corporal, potência muscular e Total Genotype Score (TGS)
Authors: Freitas Nei Adão Ribeiro de , Dall Agnol Simone Mader , Magni Cristiana , Silva Paulo Roberto da , Santos Cesar Augusto de Souza , Mascarenhas Luis Paulo Gomes 
Published: December 2022

Descrever o perfil de saúde dos grupos estudados, verificar a frequência dos alelos e dos genótipos do gene Apolipoproteína E (ApoE) e comparar os polimorfismos do gene ApoE com composição corporal, potência de membros inferiores (MMIIs) e total genotype score (TGS), a amostra foi composta por 81 indivíduos. O ácido desoxirribonucleico (ADN) foi obtido a partir de amostras do esfregaço da mucosa oral. A composição corporal foi avaliada pela balança de bioimpedância OMRON e a potência de MMIIs foi mensurada pelo tapete de contato da Hidrofit, com os testes Squat jump (SJ) e Counter moviment jump (CMJ). O grupo 1 (ɛ2) foi composto por 65% acometidos por acidente vascular cerebral (AVC), a altura dos testes CMJ 6,08±3,8 e SJ 4,77±3,4. O grupo 2 (ɛ3) foi composto 17,1% de indivíduos acometidos por AVC, a altura do CMJ 10,3±5,4 e SJ 8,3±5,2. O grupo ɛ4 apresentou indivíduos com AVC 28,6%. Altura no CMJ 11,7±7,4 e SJ 9,8±7,3. O grupo Ɛ2/Ɛ4 apresentou altura no CMJ 5,71±4,9 e SJ 4,36±3,2. Os alelos ɛ3 e ɛ4 apresentaram diferença significativa em relação ao grupo ɛ2 nos testes CMJ e SJ. As médias dos alelos foram: ɛ3 (69,8%); ɛ2 (16,6%) e ɛ4 (13,6%). O genótipo Ɛ3/Ɛ3 foi o mais prevalente (50,6%). A frequência alélica que prevaleceu na amostra deste estudo foi do alelo ɛ3 e 65 % dos portadores do alelo ɛ2 são acometidos por AVC. Os portadores do alelo ɛ3 e ɛ4 obtiveram diferença significativa na força muscular em comparação com o grupo ɛ2. O TGS se apresentou com 50, em 58% da amostra e em portadores do ɛ3.
Reply: The Persistent Absence of Empirical Evidence for Free-Riding in Global Climate Politics
Authors: Aklin Michaël , Mildenberger Matto 
Published: December 2022

Abstract
Kennard and Schnakenberg (KS) raise three concerns regarding Aklin and Mildenberger (“Prisoners of the Wrong Dilemma: Why Distributive Conflict, Not Collective Action, Characterizes the Politics of Climate Change,” Global Environmental Politics 20 (4): 4–27). In this response, we delineate where we agree and where we disagree with KS. We then consider whether the model presented by KS changes our assessment that free-riding concerns are not currently the binding constraint on global climate politics. We conclude with a refined statement of our original claim.
Prostate cancers in men under the age of 50: about a series in Togo, Sub-Saharan Africa
Authors: Darré Tchin , Djiwa Toukilnan , Kpatcha Tchilabalo Matchonna , Padja Essodina , Napo-Koura Gado , DARRE Tchin 
Published: December 2022

Abstract
Background
Prostate cancer is a public health problem and increasingly diagnosed in men under 50 years of age. This cancer occurs much more in subjects of advanced age, generally over sixty. The aim of the study was to describe the epidemiological, clinical and histopathological aspects of prostate cancer in men under the age of 50 in Togo.

Methods
It was a retrospective descriptive, cross-sectional study of histologically confirmed cases of prostate cancer in young adults at the Pathological Laboratory of Lomé over a period of 10 years (2011–2020).

Results
In total, 29 cases of prostate cancer in patients under 50 years of age. The proportion of prostate cancers in men under 50 was 0.7% of all prostate cancers, The average age of the patients was 45 years with extremes of 35 and 49 years. Twelve patients had a family history of prostate cancer, with a statistically significant relationship between the existence of a family history of prostate cancer and the age of onset of the cancer (p-value = 0.03). The dominant clinical information was prostatic hypertrophy (40.37%), followed by acute urine retention (20.69%) and micturition disorders (17.27%). The median Prostate Specific Antigen (PSA) was 188 ng/ml with extremes of 20 ng/ml and 2100 ng/ml. A large proportion of patients had a PSA between 100 and 500 ng/ml. Histologically, they were all prostatic acinar adenocarcinomas. These adenocarcinomas were well differentiated (48%) and moderately differentiated (38%). The predominant histoprognostic grade was ISUP (International Society of Urological Pathology) grade 1 which was noted in 65.52%, followed by grade 2 in 20.69%.

Conclusion
Prostate cancer in men under 50 years of age is relatively rare in Togo, sometimes occurring in the context of a family history of prostate cancer. Hence the importance of raising awareness among the male population, especially with a family history of prostate cancer, to start screening early, around the age of 40.
Critical perspectives on rehabilitation education, practice and process: northern Honduras case study
Authors: Umaefulam Valerie , Gómez-Díaz Isabel Cristina , Uribe-Calderón Laura Marcela , Pedrozo-Araque Eliany , Premkumar Kalyani , Maldonado-Molina Ethel , Basualdo Maria Laura , Bidonde Julia 
Published: December 2022

Abstract

Background
Rehabilitation services are an integral part of patient care, but in many developing countries, they are not prioritized and either unavailable or easily accessible to those who need them. Although the need for rehabilitation services is increasing in Honduras, rehabilitation workers are not included in the health care model that guides the care provided to communities, particularly in rural and remote areas. To understand the need for providing impactful rehabilitation services in disadvantaged communities, we explored the education and perception of the community relating to rehabilitation, investigated training available for rehabilitation workers, and examined the rehabilitation processes and practices in Northern Honduras from stakeholders’ experiences.

Methods
We utilized a qualitative descriptive and interpretive approach grounded in case study methodology to understand rehabilitation education, process, and practice in Northern Honduras. Three rehabilitation centres were purposefully selected as the cases, and participants consisted of rehabilitation workers and managers from these centres. We collected data via interviews and focus group sessions. We analyzed the data via thematic analysis using NVivo version 12.

Results
In Northern Honduras, rehabilitation workers' limited training and continuing education, along with awareness about rehabilitation by community members and other health providers influence rehabilitation care. Although policies and initiatives to support people with disabilities and the broader community in need of rehabilitation exist, most policies are not applied in practice. The sustainability of rehabilitation services, which is rooted in charity, is challenged by the small range of funding opportunities strongly affecting rehabilitation care processes and clinical practices. The lack of trust and awareness from the medical profession towards rehabilitation workers sets a major barrier to referrals, interdisciplinary work, and quality of life for individuals in need of rehabilitation.

Conclusion
This study advances knowledge of the need to increase understanding of rehabilitation care among community members and health providers, improve care processes and resources, and foster interprofessional practice, to enhance the quality of care and promote equitable care delivery, especially in rural and remote communities.
Hospital admissions due to snake envenomation in the Republic of Cyprus: a 7-year retrospective review
Authors: Jestrzemski Daniel , Athanasiadou Maria , Scoutellas Vasos , Ghezellou Parviz , Spengler Bernhard , Gessler Frank , Kuch Ulrich 
Published: December 2022

Abstract
Background
Snake envenomation is a major neglected tropical disease, lacking data in many countries including Cyprus, a Mediterranean island inhabited by the medically important blunt-nosed viper (Macrovipera lebetina). Reviewing the 2013–2019 period, we present first-time epidemiological snakebite data in the Republic of Cyprus.

Methods
We obtained data on snake envenomation-related hospital admissions from the Ministry of Health, and population and rainfall data from the Statistical Service of Cyprus and Department of Meteorology websites. Human-viper conflict information was acquired from interviews with 12 representatives of Cypriot institutions.

Results
Between 2013 and 2019, 288 snake envenomation cases were admitted to public hospitals, averaging 41 people annually. The minimum was 29 cases (2017) and the maximum was 58 (2015). Snake envenomation incidence increased from 4.55 per 100,000 population (2013) to 6.84 (2015), but remained low since 2017 (3.49 in 2019). Between 2000 and 2018, the deaths of one man (73 years), and indirectly, one woman (77 years), were related to snake envenomation. While 266 cases (92%) happened between April and October (the blunt-nosed viper activity period), most envenomations occurred in September (cumulative for 2013–2019), with 88 cases (31%). Snakebite incidence peaked in the 60–69 years age group (9.19 per 100,000 population), and was higher in males (6.85) than in females (2.82). Of all admitted patients, 242 (84%) were discharged within 4 days. Mean hospital stay duration was 2.65 days, with one case of 13 days. Most patients were admitted to the general hospitals in Paphos (51%), Limassol (30%) and Nicosia (11%), which provide secondary healthcare, with the last one providing tertiary healthcare.

Conclusions
Snakebite-related deaths are very rare in the Republic of Cyprus. Most envenomation cases happened in late summer (September). Short hospital stays indicate mostly non-severe clinical courses. The hospital admission data suggest that snake envenomation risk is highest in Paphos district. The statistical data hint at males and middle- to older-aged people being at highest risk, whereas from our interview data we assume that outdoor workers are at higher risk than other occupational groups.
Discovery of novel natural products for mosquito control
Authors: Engdahl Cecilia S. , Tikhe Chinmay V. , Dimopoulos George 
Published: December 2022

AbstractVector control plays a key role in reducing the public health burden of mosquito-borne diseases. Today’s vector control strategies largely rely on synthetic insecticides that can have a negative environmental impact when applied outdoors and often become inefficient because of the mosquitoes’ ability to develop resistance. An alternative and promising approach to circumvent these challenges involves the implementation of insecticides derived from nature (biopesticides) for vector control. Biopesticides can constitute naturally occurring organisms or substances derived from them that have lifespan-shortening effects on disease vectors such as mosquitoes. Here we present the discovery and evaluation of natural product-based biological control agents that can potentially be developed into biopesticides for mosquito control. We screened a natural product collection comprising 390 compounds and initially identified 26 molecules with potential ability to kill the larval stages of the yellow fever mosquitoAedes aegypti, which is responsible for transmitting viruses such as dengue, Zika, chikungunya and yellow fever. Natural products identified as hits in the screen were further evaluated for their suitability for biopesticide development. We show that a selection of the natural product top hits, bactobolin, maytansine and ossamycin, also killed the larval stages of the malaria-transmitting mosquitoAnopheles gambiaeas well as the adult form of both species. We have further explored the usefulness of crude extracts and preparations from two of the best candidates’ sources (organisms of origin) for mosquitocidal activity, that is extracts from the two bacteriaBurkholderia thailandensisandStreptomyces hygroscopicusvar.ossamyceticus.Graphical abstract
Adsorption of insulin onto neonatal infusion sets: should intravenous administration of insulin to treat hyperglycemia in preterm babies on the NICU be proceeded by priming of the intravenous system, adding of albumin, or non-priming to get to a stable insulin dose?
Authors: Mian Paola , Bolhuis Mathieu S. , Maurer J. Marina , van Stuijvenberg Margriet 
Published: December 2022

AbstractInsulin is used to treat neonatal hyperglycaemia when blood glucose concentrations are consistently high, and to treat neonatal diabetes. Within this brief report, a review of the existing literature is conducted to determine if intravenous administration of insulin should be proceeded by priming of the intravenous system, adding of albumin, or non-priming to get a stable insulin dose. Within this literature search, we focused on experimental insulin adsorption data (in vitro studies).
Racial and incident discrepancies in news media reporting of sudden unexpected infant death (SUID)
Authors: Lazarus Sarah Gard , Miller Terri , Hudson Philip J. , McFadden Terri , Baas Gretchen , Kendi Sadiqa 
Published: December 2022

AbstractBackgroundRegardless of injury prevention and outreach efforts, there continue to be low rates of adherence with the American Academy of Pediatrics (AAP) safe sleep recommendations. Media is an important tool for parental education and may influence risk perception and caregiver choices. Due to media reports potentially serving as an opportunity for shaping social norms, caregiver education and injury prevention, an evaluation was undertaken to evaluate Georgia local news reporting of sudden unexpected infant death (SUID) as compared to drownings, homicides, and firearm injuries. Our objective was to evaluate incident and racial discrepancies in Georgia news media reporting of SUID as compared to other pediatric injury deaths.ResultsDespite its high incidence, SUID was far less commonly mentioned in the news media, with only 1.9% (10/525) mentioned as compared to 8.1% of drownings (17/211), 11.4% (74/649) of MVC’s, 14.7% (59/402) of homicides between ages 1–18, 20% (11/55) of fire-related deaths and 25% (15/59) of homicides under age one (infant homicides). Across SUID and homicide, deaths of White infants were reported in the news media at 2.5 times the rate of Black infants.ConclusionDespite SUID being a leading cause of infant death, it is infrequently mentioned in the news media. When mentioned, the news media are more likely to highlight the deaths of White infants as compared to Black infants, though the incidence rate of SUID is higher in Black infants as compared to White.
The Politics of Plagiarism
Authors: Tanna Natasha 
Published: December 2022

Abstract
This article analyzes queer literary politics and the engagement with cultural precursors in the 1990s and into the twenty-first century in works by Cuban writer Ena Lucía Portela and Argentine writer María Moreno. The lack of a clearly defined tradition of lesbian/queer literature by women in Cuba and Argentina leads these two writers to appropriate or invent their own during periods of increasing liberalization in their respective countries. At first glance, Portela and Moreno’s joyful gestures of what this essay conceptualizes as “creative plagiarism” appear to signal their reveling in a cosmopolitan commons, largely situated in the United States and Europe, via Paris of the années folles (Crazy Years), from which fragments can be drawn to create queer counter-canons. However, the article concludes that through their highly intertextual works both writers reflect critically on the location of the so-called cosmopolitan in queer literary genealogies and on power dynamics and hierarchies among both authors and characters and different creative forms, including academic writing. The article argues that while the diegesis of their texts is largely set outside their local contexts, both writers’ works are deeply located in Cuba and Argentina. Ultimately, Portela and Moreno claim authority for creative writers themselves, as well as their nonliterary cocreators, reflecting critically on literary scholarship.
Τρόποι αντιμετώπισης του άγχους της πανδημίας
Authors: Χριστοπούλου Αγάπη 
Published: December 2022

Το ζήτημα της αντιμετώπισης των ψυχολογικών επιπτώσεων της πανδημίας, αποτελεί ένα καίριο πρόβλημα που εντάσσεται στα ενδιαφέροντα της επαγγελματικής μου σταδιοδρομίας, καθώς θα ήθελα να ακολουθήσω το επάγγελμα του. Η παρούσα εργασία έχει ως στόχο την έκθεση ενός καίριου προβλήματος, δηλαδή αυτου του άγχους της πανδημίας, σε διάφορες κοινωνικές και ηλικιακές ομάδες, καθώς και τρόπους και συμβουλές αντιμετώπισής του.
Όμιλος «Σύνδεση Εκπαίδευσης & Εργασίας» , Πρότυπο Γενικό Λύκειο Ευαγγελικής Σχολής Σμύρνης
Authors: Argyri Panagiota 
Published: December 2022

Οι εργασίες αυτού του τεύχους είναι αποτελέσμα των δραστηριοτήτων των μαθητών/ τριών του Ομίλου «Σύνδεσης Εκπαίδευσης & Εργασίας», που υλοποιήθηκε στο Πρότυπο Γενικό Λύκειο Ευαγγελικής Σχολής Σμύρνης, το σχολικό έτος 2021-22, με υπεύθυνη εκπαιδευτικό την Μαθηματικό (M.Sc, M.ed) κα Αργύρη Παναγιώτα, σε συνεργασία με το Παιδαγωγικό Τμήμα Δευτεροβάθμιας Εκπαίδευσης του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών, το Σύνδεσμο Αποφοίτων της Ευαγγελικής Σχολής Σμύρνης, το Σύλλογο Γονέων & Κηδεμόνων Λυκείου Ευαγγελικής Σχολής Σμύρνης και υπό την Αιγίδα του Δήμου Νέας Σμύρνης.
Η συγγραφή των θεμάτων αυτών των ερευνητικών εργασιών είναι αποτέλεσμα της αξιοποίηση των εμπειριών, των γνώσεων, των στάσεων και των δεξιοτήτων που αναπτύχθηκαν από την αλληλεπίδραση με τα επαγγελματικά ζητήματα των χώρων εργασίας, όπου οι μαθητές/τριες πραγματοποίησαν εκπαιδευτικές επισκέψεις. Μέσα από την βιβλιογραφική επισκόπηση κοινωνικών, πολιτικών και επιστημονικών ερευνητικών μελετών περιλαμβάνονται θέματα από διαφορετικά πεδία επαγγελματικής σταδιοδρομίας. Αναλυτικότερα, ζητήματα από τον Τομέα Υγείας περιλαμβάνουν τη χρήση θεμελιωδών μαθηματικών γνώσεων για την κατανόηση των ιδιοτήτων του ανθρώπινου γενετικού υλικού, την ανάλυση των τεχνικών αντιμετώπισης του καρκίνου του πνεύμονα με τη χρήση της νανοτεχνολογίας, αλλά και την χρήση της θεωρίας των πιθανοτήτων στην διάγνωση των αποτελεσμάτων της μαστογραφίας. Οι ψυχικές επιπτώσεις της πανδημίας, αλλά και η διαχείριση του άγχους εντάσσονται στο πεδίο των ανθρωπιστικών/ κοινωνικών επιστημών και στην προσομοίωση του ρόλου του επαγγελματία ψυχολόγου. Στο πεδίο αυτό αναλύεται και η επιστήμη της εγκληματολογίας. Η δωρεά οργάνων και οι μεταμοσχεύσεις είναι ένα ζήτημα από το πεδίο διαχείρισης των πολιτικών επιστημών. Το ενδιαφέρον ενασχόλησης με το επαγγελατικό πεδίο της Φυσικής περιλαμβάνει την εργασία για την εξέταση των πειραμάτων ATLAS και CMS στον LHC του CERN. Τέλος, το επαγγελματικό της αρχιτεκτονική συνδέεται με τον τομέα των φυσικών καταστροφών και της αντισεισμικότητας καθώς και τους τρόπους με τους οποίους μπορεί να επιτευχθεί ένας αντισεισμικός μηχανισμός.
Organization Strategy Development Tools
Authors: Lyandau YUriy , Bykova O. , YElina Olga , Ter-Ovanesov D. 
Published: December 2022

The article discusses the tools that are used to develop and implement strategies of organizations operating in various sectors of the economy. A balanced scorecard, which includes a strategic map and a table of activities, acts as a key tool for developing an organization's strategy. The strategic map defines the required number of prospects, goals and indicators to measure the level of achievement of goals, and the table already describes the current and target values, activities and results. Together with a balanced scorecard, it is advisable to use the methodology «goals and key results» in order to describe the intermediate results that will allow achieving the goals.
The authors show that when developing strategic maps, it is possible to take into account ESG transformation or the specifics of work in ecosystems. To the four basic perspectives (finance, customers, business processes, training and development), an environmental perspective can be added, taking into account environmental factors in the ESG transformation concept. You can also use the perspective of partners, in the case of considering a business in the ecosystem format.
As alternatives to a balanced scorecard, the article considers: the efficiency pyramid of K. McNair, R. Lynch and K. Cross, with which you can describe the strategy of the organization, defining financial indicators, non–financial indicators, as well as actions that take into account the external and internal environment of the organization; the EP2M model, L. Meisel's strategic maps, the prism of efficiency, taking into account 5 perspectives of the organization – satisfaction of stakeholders, strategy, processes, opportunities, as well as contribution interested parties.
The article concludes that in order to develop a strategy, it is advisable to use the integration of the analyzed tools, depending on the scope of activity, the type of strategy, and the principles of development.
La biografia parlamentària en la historiografia basca
Authors: Cattini Giovanni C. 
Published: December 2022

Ressenya de
Joseba Agirreazkuenaga i Mikel Urquijo (dirs.), Diccionario biográficode los diputados y diputadas del Parlamento Vasco (1980-1984), 2 vols.,Bilbao, Eusko Legebiltzarra / Parlamento Vasco, 2021.