bluuebunny/crossref_metadata_2025_split huggingface dataset:
A network pharmacology approach to decipher the total flavonoid extract of Dracocephalum Moldavica L. in the treatment of cerebral ischemia- reperfusion injury
Authors: Hu Xu , Mola Yideresi , Su Wen-ling , Wang Yue , Zheng Rui-fang , Xing Jian-guo 
Published: July 2023

Background and objective
Cerebral ischemia-reperfusion injury (CIRI) is a major injury that seriously endangers human health and is characterized by high mortality and high disability. The total flavonoid extract of Dracocephalum moldavica L.(TFDM) in the treatment of CIRI has been proved by clinical practice. But the mechanism for the treatment of CIRI by TFDM has not been systematically revealed.

Study design and methods
The active compounds contained in TFDM were screened by literature mining and pharmacokinetic parameters, and the targets related to CIRI were collected by searching Drugbank, Genecards and OMIM databases. Cytoscape software was used to construct the protein interaction network of TFDM for the prevention and treatment of CIRI. Geneontology and signal pathway enrichment were analyzed. The key target pathway network of TFDM compounds was constructed and verified by pharmacological experiment in vitro.

Results
21 active components were screened, 158 potential drug targets for the prevention and treatment of CIRI were obtained, 53 main targets were further screened in the protein-protein interaction network, and 106 signal pathways, 76 biological processes, 26 cell components and 50 molecular functions were enriched (P<0.05). Through the compound-target-pathway network, the key compounds that play a role in the prevention and treatment of CIRI, such as acacetin, apigenin and other flavonoids, as well as the corresponding key targets and key signal pathways, such as AKT1, SRC and EGFR were obtained. TFDM significantly decreased LDH, MDA levels and increased the NO activity levels in CIRI. Further studies have shown that TFDM increases the number of SRC proteins, and TFDM also increases p-AKT/ AKT. Molecular docking results showed that acacetin-7-O (- 6’’-acetyl) -glucopyranoside, acacetin7-O-β-D-glucopyranoside, apigenin-7-O-β-D-galactoside respectively had good affinity for SRC protein. Acacetin-7-O (- 6’’-acetyl) -glucopyranoside,acacetin-7-O-β-D-glucuronide, acacetin7-O-β-D-glucopyranoside had good affinity for AKT1 protein, respectively.

Conclusion
Our research showed that TFDM had the characteristics of multi-component, multi-target and multi-channel in the treatment of CIRI. The potential mechanism may be associated with the following signaling pathways:1) the signaling pathways of VEGF/SRC, which promote angiogenesis, 2) the signaling pathways of PI3K/AKT, which inhibit apoptosis, and 3) acacetin-7-O (- 6’’-acetyl) -glucopyranoside is expected to be used as a candidate monomer component for natural drugs for further development.
Literary and critical encounters with the Anthropocene: An interview with Seán Hand
Authors: Zou Li , Hand Seán 
Published: July 2023

Abstract
Seán Hand is Professor of French Studies at the University of Warwick and Deputy Pro-Vice-Chancellor (Europe) of the University of Warwick. His research mainly focuses on literature, ideas and related developments in France and other Western countries from the early twentieth century to the present day. In this wide-ranging interview, Hand points out that there is a competition of intellectual versions of the Anthropocene, such as Capitalocene, Plantationocene and Chthulucene. With regards to the situation of the Anthropocene, he argues that literary and critical studies should move beyond masterful exposition of a work and take up the task of calling attention to our actions, renewing our connection and commitment to the life-web we inhabit, and engaging critically with technologization discussions. Hand also discusses the relationships between the “post-human turn” and the “non-human turn” and suggests that while post-human is connected with a teleological notion of development into a “beyond”, non-human is more grounded in today’s, and yesterday’s, reality. As an analyst of Emmanuel Levinas’s philosophy, he here maintains that while Levinas’s insights on alterity could not be unproblematically applied in dealing with the “Anthropocene”, Levinasian ethics and Anthropocene concerns could produce transformative insights and effects. Lastly, Hand gives inspiring suggestions on the career development of young scholars and emphasizes the importance of doing multi-disciplinary, inter-disciplinary and international studies.
“Old things made new”: Transfusive rejuvenescence in M. E. Braddon’s “Good Lady Ducayne” and H. G. Wells’s “The Story of the Late Mr. Elvesham”
Authors: Green James Aaron 
Published: July 2023

AbstractIn 1897, congratulating Bram Stoker on the release ofDracula, the writer M. E. Braddon tries to establish precedence for herself by classifying the novel not, as we might expect, as a story of vampirism, but as one of “transfusion”. Taking this designation as its cue, this article recovers examples of what I term “transfusive rejuvenescence fiction”, in which a prolongation of life or restoration of youth is achieved via corporeal transferal. It contextualizes this sub-genre by charting how a revival of interest in blood transfusion’s rejuvenatory promise occurred alongside shifts in the attitudes to age and aging – to old age especially. Contrary to medical writers, who optimistically envisaged transfusion as an integral part of a “sentimental economy” – in which blood is donated out of “fellow-feeling” – transfusive rejuvenescence fiction raises the prospect of bloodborne youthfulness becoming commodified and circulating according to the tenets of the capitalist marketplace. In these fictions, transfusion serves as an evocative and versatile figure for expressing anxieties around the increasingly urgent question of provision for old age and the issues of intergenerational equity implied therein. To prove the argument, this article performs a comparative reading of Braddon’s “Good Lady Ducayne” and H. G. Wells’s “The Story of the Late Mr. Elvesham”, both of 1896. The comparable but distinctive approaches taken by these two short stories means that examining them in tandem provides us with a fuller picture of the contributions that transfusive rejuvenescence fiction made to fin-de-siècle discourses of age and aging.
“Inside many of us / is a small old man” – age/ing in Anne Sexton’s Transformations: A community discussion
Authors: Zittlau Andrea 
Published: July 2023

Abstract
The poetry book Transformations by Anne Sexton consists of seventeen poems based on the versions of fairytales by the Brothers Grimm. Told by Sexton, the tales become sharp comments on American culture, changing characters and action to focus on gender, power systems and medical histories. Analyzing the poems “Snow White and the Seven Dwarfs”, “Rapunzel”, and “Rumpelstiltskin”, this article focusses on Sexton’s revelation of the aging and ageism inherent in both the fairytales and contemporary American culture. I am interested in a reading of the poems beyond the confessional approach so common in analyses of Sexton’s poetry, focusing instead on how the characters struggle with beauty expectations, age and gender roles as well as loneliness. Therefore, I have discussed the chosen poems with different communities beyond the academic context with an interest in other approaches and experiences applied in the readings. The voices are woven into the article, adding to the analysis and offering a comment on contemporary reading practices.
The wisdom of intergenerational relationships in Ursula Le Guin’s series Annals of the Western Shore (Gifts, VoicesandPowers)
Authors: Oró-Piqueras Maricel , Benderska Yuliia 
Published: July 2023

AbstractUrsula Le Guin’s novels included in Annals of the Western Shore, published between the years 2004 and 2007, have as protagonists three young characters who, among uprising, rebellion and unfair states, have to find their place in Le Guin’s the Western Shore world. The three protagonists share a gift – the gift of remembering and telling stories – which is transmitted to two of them through an older man from the community where they live. Once the main characters come together at the end of the third novel of the saga, they realise that the only way in which a free and prosperous state can be achieved is through knowledge and the sharing of the stories of both ancestors and new writers. The series, thus, problematizes the concept of wisdom associated with a binary stereotypical image of old age as either attached to loss and decrepitude or to wisdom, particularly in the fantastic mode. In this article, and following Le Guin’s belief in the intrinsic interconnectivity of all things, “organic and inorganic, material and spiritual, object and force – [that] shape and are shaped by each other” (Senior 1996: 104), we aim to explore the value of intergenerational relationships in building a fairer and more prosperous society in Le Guin’s series Annals of the Western Shore. Whereas the young characters and protagonists in each of the three novels need the guidance of older members of their communities to come to terms with their “gifts”, the coming of age of these young protagonists will also question the unfair and destructive beliefs behind the social organisation of the regimes in which they grew up and became adults.
Éilís Ní Dhuibhne’s Little Red and Other Stories and gerotranscendence on the page
Authors: Zarebska Zuzanna 
Published: July 2023

Abstract

Little Red and Other Stories is a collection of short stories that taps into many different dimensions of older women’s existence, exploring characters who are often bereft or in search of a more meaningful expression of their identity. Divided by physical and non-physical frontiers, gerontological challenges persist as much as the desire to live in spite of internal and external changes. The stories are shaped by mortality and by the subjective and imaginary discourses of culture, with the issues of autonomy, agency, intimacy and well-being remaining at their core. Little Red and Other Stories provides us with a multidirectional perspective on the aging process. It offers stories that see characters move towards a greater experience of agency and relational freedom. The internal interrogations and external interpellations present in the narratives are reinforced by the author’s use of metatextuality, bearing in mind her expertise in folk literature and mythology. She deliberately places her characters in unusual circumstances in order to convince her reader that if crossing of the real/fantastic worlds is possible, it is also possible to cross, or challenge, age definitions. If transgressions are possible on the page, we, too, have the capacity to create our own life-narratives and be agentic in our older age, a time conventionally seen as stagnant, limited and dominated by decline. Indeed, older people, mostly women in Ní Dhuibhne, have an extraordinary capacity to translate their experience into wisdom and possess the necessary stamina to rewrite their stories.
Rewriting rules, changing worlds: Diegetic and ludic forms of metareference in The Magic Circle
Authors: Krampe Theresa 
Published: July 2023

Abstract
In addition to transmedial techniques such as metalepses, allegories, or obtrusive narrators, contemporary videogames also use medium-specific forms, including game rules, mechanics, or interfaces, to create metareference. Similarly, metareferential games seem not only concerned with questions of their fictionality but show particular interest in their own technological infrastructure and embeddedness in digital culture. In this article, I propose a systematic approach to analysing metareference in videogames, distinguishing between the gameworld and the game system as the two main layers of communication from which metareference emerges. In a case study of the indie metagame The Magic Circle (Question 2015), I show that the game’s distinctive metareferential style is the result of interactions between what I call diegetic and ludic forms of metareference, and which are produced at the level of the gameworld and the game system, respectively.
Unresolved conflicts and suspended ethics: Reading “The Monster” from the perspective of voice
Authors: Kang Mengni 
Published: July 2023

Abstract
This article draws on rhetorical narrative theory and makes a case for Stephen Crane’s employment of the resource voice to communicate the naturalistic theme of “The Monster”. It argues that by modulating voices on different communicative tracks, the author invites us to recognize two pairs of conflicting forces: one of free will and external forces that shows in the causes of Henry’s and Trescott’s heroic acts, and the other of individual agency and collective identity that characterizes the narrative’s engagement with Whilomville. It is my view that the author invites readers to share his naturalistic outlook and refrain from making conclusive ethical judgments on the characters and the community. For readers, attending to the synthesis of tone, style, and values in utterances helps with inferring the author’s rhetorical purposes. To this end, the article also considers Crane’s biographical information and newspaper sketches, calling for the inclusion of contextual and intertextual matters in rhetorical criticism.
Insights from an empirical study on communicative functions and L1 use during conceptual mediation in L2 peer interaction
Authors: Nadal Sanchis Laura , Bello Viruega Iria 
Published: July 2023

Abstract
Conceptual mediation is one of the competences described by the Common European Framework of Reference (CEFR) during the acquisition of foreign languages. When practicing mediation, learners collaborate in the construction of knowledge to conduct activities that require higher-level cognitive skills, such as teamwork. This study analyzes the communicative functions and L1 use in peer interaction during a conceptual mediation activity in a group of students following Content Language Integrated Learning (CLIL) instruction and another receiving traditional language tuition. The sample was made up of 60 L1 Spanish, L2 German speakers enrolled in a A2.2 German course (age 18–20). For the analysis, the oral interaction of the groups was recorded through an online videoconference platform. The type of mediation used as well as the presence or absence of speakers’ L1 (Spanish) were assessed. The analysis demonstrates that groups following a CLIL approach resorted to regulative discourse for work organization purposes (relational mediation) more frequently than those students following a more traditional approach. Regarding the use of the L1, non-CLIL groups used their first language to a greater degree in regulative discourse and during communicative mediation, that is, when they had to resort to translation to ensure comprehension among peers.
Fabrication and performance analysis of sustainable municipal solid waste incineration fly ash alkali-activated acoustic barriers
Authors: Dong Peng , Yuan Hongyan , Wang Quan 
Published: July 2023

Abstract
The recycling of hazardous municipal solid waste incineration fly ash (MSWIFA) is drawing more attention, in which the alkali-activation technique may provide great potential to make full use of it as sustainable acoustic materials. The present work evaluated the applicability of alkali-activated MSWIFA-based materials (AAFMs) as porous acoustic barriers. The chemical composition and microtomography of the as-prepared AAFMs were characterized by X-ray diffraction. Fourier-transform infrared spectroscopy, and scanning electron microscopy. With the incorporation of MSWIFA and foaming agents, the dry bulk density and porosity of AAFMs were subsequently examined. Moreover, the compressibility and leachability of AAFMs were also investigated to evaluate their mechanical performance and environmental safety as construction materials. A sound absorption test was eventually conducted to explore the sound absorption performance of AAFMs, considering the main factors such as aluminum addition, MSWIFA dosage, and sample thickness. The results verified the good chemical stability, leachability, and sound absorption performance of porous AAFMs. Specifically, it indicated that the aforementioned factors have a boosting effect on forming highly porous structures that improve sound absorption performance, namely sound absorption coefficient and noise reduction coefficient.
In memoriam : Régine Robin (1939-2021)
Authors: Balint Adina 
Published: July 2023

Ce texte rend hommage à Régine Robin (1939-2021), écrivaine, historienne, sociologue et traductrice d’origine juive polonaise qui vécut entre Paris et Montréal, dont l’œuvre aux multiples facettes apporte une contribution pertinente à la culture et à la critique contemporaines en français. This text pays tribute to Régine Robin (1939-2021), writer, historian, sociologist and translator of Jewish origin, who lived between Paris and Montréal, and whose multi-faceted work brings an essential contribution to French contemporary culture and critical theory.
“Black Sisyphus”, de Claire Harris: discussões sobre humanidade na perspectiva decolonial
Authors: Schneider Liane , Almeida Sandra Regina Goulart 
Published: July 2023

Ao longo do presente artigo, propomos um olhar crítico sobre o poema de Claire Harris, intitulado “Black Sisyphus”, em que é recriada uma elação entre uma figura paterna negra e uma criança de seis anos, relendo as tradições culturais ocidentais por outro viés se comparadas às culturas clássicas construídas em torno dessa figura mitológica. Partimos de leituras analíticas de Lynette Hunter, Rosemary Sullivan, Smaro Kamboureli e George Elliot Clarke com o intento de olhar criticamente para os vários discursos sobre a produção poética da autora canadense-caribenha em foco. Também damos voz a autores como Spivak, Quijano, Mignolo e Lugones a fim de localizar o debate pelo viés decolonial. A experiência negra aparece aqui marcada pelos descolamentos vivenciados entre as Américas e a África, afinados com o debate decolonial, destacando a resistência construída de forma intergeracional.
River Revery: Penn Kemp nos convida a caminhar junto ao Rio Thames
Authors: Nenevé Miguel 
Published: July 2023

Resenha de RIVER REVERY, de Penn Kemp CPenn Kemp é uma poeta canadense conhecida de brasileiros por sua produção poética. Já esteve em congresso da ABECAN (Belo Horizonte, novembro de 2003) quando falou sobre sua poesia performática, vindo depois a Porto Velho onde apresentou e representou alguns de seus poemas junto com poetas e músicos locais. Penn teve também alguns poemas traduzidos para o Português e publicados pelo Núcleo de Estudos Canadenses (RO) em parceria com a ABECAN. Hoje, aos setenta e sete anos, a poeta de London Ontario continua fazendo sua “catequese poética”, vivendo e escrevendo intensamente, congregando, articulando, diminuindo barreiras por meio de sua poesia. Sua inspiração parte de seres humanos e não humanos que comungam com ela a atmosfera ao seu redor, no sul de Ontario. Assim, Penn integra sua poesia a outras artes, trazendo, muitas vezes, o lúdico para sua produção criativa. Por isso é também reconhecida como inovadora na forma de apresentar seus escritos desde a publicação em 1972.
Bioarqueologia dos Primeiros Habitantes do Brasil Central: saúde e estilo de vida na região de Lagoa Santa, Minas Gerais
Authors: Da-Gloria Pedro 
Published: July 2023

Resumo: A região arqueológica de Lagoa Santa é conhecida internacionalmente pela grande quantidade de esqueletos humanos antigos escavados em grutas e abrigos sob rocha desde o século XIX. Todavia, até recentemente uma integração sólida entre dados arqueológicos e biologia esqueletal não tinham sido realizados na região. Neste trabalho, analisamos 195 esqueletos humanos de Lagoa Santa datados entre 10.000 e 7.000 anos AP, discutindo: i) saúde bucal e subsistência; ii) atividade física e tecnologia; iii) infecções, mobilidade e ocupação do território; e iv) estresse durante o crescimento e desenvolvimento, violência interpessoal e conflitos sociais. Os resultados mostraram uma população caçadora-coletora com subsistência fortemente baseada em vegetais, alta atividade física, pouca mobilidade e estresse fisiológico, infeccioso e social, a aproximando de padrões de saúde observados em populações agricultoras. Neste texto, enfatizamos o enorme potencial informativo da bioarqueologia na reconstrução de aspectos bioculturais de populações antigas.Abstract: The archaeological region of Lagoa Santa is internationally known for its large collection of ancient human skeletons excavated from caves and rock shelters since the 19th century. However, a solid integration between archaeological data and skeletal biology had not been carried out in the region to date. In this article, we analyze 195 human skeletons from Lagoa Santa dated between 10,000 and 7,000 years BP, discussing: i) oral health and subsistence; ii) physical activity and technology; iii) infections, mobility and occupational patters; and iv) stress during growth and development, interpersonal violence and social conflicts. The results showed a hunter-gatherer population with subsistence strongly based on plants, high physical activity, low mobility, and physiological, infectious, and social stress, approaching health patterns observed in agricultural populations. We emphasize here the enormous contribution of bioarchaeology in reconstructing biocultural aspects of ancient populations. ‌
Ladrilhos Hidráulicos do Recôncavo da Bahia: mapeamento e estudo dos padrões compositivos em Cachoeira - Bahia
Authors: Comerlato Fabiana , Santos Aline Marçal , Teixeira Caroline Pereira , Mota Ritta Maria Morais Correia 
Published: July 2023

Resumo:O ladrilho hidráulico é uma placa de cimento constituída de areia, pó de mármore e pigmentos com superfície de textura lisa, sendo mais utilizado como piso. A ideia inicial da pesquisa surgiu em razão da recolha de ladrilhos hidráulicos de demolições e reformas de edificações históricas da cidade de Cachoeira, no Recôncavo da Bahia. A pesquisa compôs dois planos de trabalho: um relativo à necessidade de compreender as técnicas de produção e sua cadeia operatória nos locais de produção - oficinas tradicionais -, bem como seus padrões compositivos; e o outro à realização do levantamento da existência e preservação de ladrilho hidráulico nas edificações do centro da cidade. A pesquisa, também, buscou sensibilizar os moradores para a manutenção e preservação desses pisos artísticos em Cachoeira, Bahia. Abstract:The hydraulic tile is a cement tile made of sand, marble powder and pigments. It has fine texture and has been used as floor coverings. The original idea of this research began from collecting tiles discarded from renovations and demolitions of historical buildings in the city of Cachoeira, Recôncavo da Bahia. The research was done in two work plans: one related to understanding the manufacturing process in the traditional workshops, and the other to document and preserve all the existing hydraulic tiles within buildings in the downtown area. The research also tried to sensitize its residents for the maintenance and preservation of these artistic floors in Cachoeira, Bahia.