bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multigram Synthesis of Dimethyl Stellane‐1,5‐Dicarboxylate as a Key Precursor for ortho‐Benzene Mimics**
Authors: Smyrnov Oleh K. , Melnykov Kostiantyn P. , Rusanov Eduard B. , Suikov Sergey Yu. , Pashenko Olexandr E. , Fokin Andrey A. , Volochnyuk Dmytro M. , Ryabukhin Serhiy V. 
Published: September 2023

AbstractHerein, we present previously unavailable C(sp3)‐rich polycyclic hydrocarbon scaffolds that have the potential to become valuable tools in medicinal chemistry and crop science as saturated bioisosteres of benzenoids. We have developed a scalable protocol (up to 50 g from a single synthetic run) for the synthesis of tricyclo[3.3.0.03,7]octane (bisnoradamantane or stellane) 1,5‐dicarboxylic acid derivatives. X‐ray crystallographic analysis of the stellane 1,5‐dicarboxylic acid dimethyl ester has revealed that this scaffold is an optimal saturated isostere for ortho‐disubstituted benzene where substituents exhibit in‐plane topology. The synthetic protocol is based on the oxidative cyclization of dimethyl octahydropentalene‐2,5‐dicarboxylate (DMOD) through lithiation followed by I2 oxidation. The reaction outcome is determined by the stereochemistry of the substrate. While the endo,endo cis‐DMOD, exclusively gives the “unwanted” Claisen cyclization product, the exo,endo cis‐ and exo,exo cis‐ stereoisomers afford the desired stellane 1,5‐dicarboxylic acid dimethyl ester quantitatively. DFT computations have revealed that the reaction proceeds via the dianion of dimethyl octahydropentalene‐2,5‐dicarboxylate, which undergoes SET oxidation by I2 to form a radical anion. The subsequent cyclization followed by a second SET oxidation gives the desired stellane derivative.
A robustly stabilizing fault‐tolerantMPC: A performance improvement‐based approach
Authors: Santos Rodrigo Ribeiro , Martins Márcio A. F. , Sotomayor Oscar A. Z. 
Published: September 2023

AbstractIn terms of model predictive control (MPC) performance degradation caused by operational faults, in this article, a robust MPC strategy with active fault tolerance properties is proposed. The proposed strategy incorporates a fault supervision layer into the structure of conventional cost‐contracting formulation‐based robust MPC for the online update of the nominal controller model in the event of faults. The robust MPC is based on multiplant uncertainty, while the supervisory layer consists of a bank of unknown input observers and a decision‐making algorithm. Simulation results in a nonlinear polymerization reactor subject to process faults demonstrate that the proposed approach offers superior performance compared to the conventional strategy.
Plant‐wide control for processes with recycle and narrow feasible sets
Authors: Obando Andres , Muñoz Diego A. 
Published: September 2023

AbstractRecycling mass and energy is a feature in almost all plants and industries. It is reported as an inevitable characteristic in actual industries due to differences between the designed processes and implementation. When a process is set, engineers identify inefficiencies in the planned performance and utilize recycles to try to reduce this difference. However, although recycles help in improving a plant's overall performance compared with a serial arrangement, its effect on dynamic plant behaviour is seldom considered, and these changes begin to impact the features of processes like controllability and stability. Similarly, even though recycles affect the feasible region of individual equipment, its effect is not verified. Based on the aforementioned background, several studies have demonstrated that advanced control strategies allow for the improvement of the dynamic behaviour of complex plants. Different techniques, such as model‐based predictive control and plant‐wide control (PWC), also show that their implementation reduces the effects of recycles. However, there is no explicit methodology to design these controllers and address the impacts of recycles on dynamic behaviour and feasibility. Additionally, there is no tuning procedure to design controllers that optimize the dynamic performance of plants, including the control system. In this context, this work presents an analysis to characterize the effects of recycles on the dynamic behaviour of plants, including how they affect the feasible operating region. Based on the previous analysis, a control methodology is also proposed to design the PWC strategy, explicitly addressing the dynamical phenomena of recycles in processes.
Relationship Between Stress Modulated Metallicity and Plasmon in Graphene Nanoribbons
Authors: Zhang Na , Yang Zhiyuan , Zhang Zhongyuan , Wang Jingang 
Published: September 2023

AbstractNanoscale quantum plasmon is an important technology that restricts the application of optics, electricity, and graphene photoelectric devices. Establishing a structure–effect relationship between the structure of graphene nanoribbons (GNRs) under stress regulation and the properties of plasmons is a key scientific issue for promoting the application of plasmons in micro‐nano photoelectric devices. In this study, zigzag graphene nanoribbon (Z‐GNR) and armchair graphene nanoribbon (A‐GNR) models of specific widths were constructed, and density functional theory (DFT) was used to study their lattice structure, energy band, absorption spectrum, and plasmon effects under different stresses. The results showed that the Z‐GNR band gap decreased with increasing stress, and the A‐GNR band gap changed periodically with increasing stress. The plasmon effects of the A‐GNRs and Z‐GNRs appeared in the visible region, whereas the absorption spectrum showed a redshift trend, indicating the range of the plasmon spectrum also underwent significant changes. This study provides a theoretical basis for the application of graphene nanoribbons in the field of optoelectronics under strain‐engineering conditions.
Is ambidextrous learning a driver for SMEs' sustainable competitive advantage in the digital era? An empirical study of SMEs in Nanjing, China
Authors: Lyu Chaolin , Peng Can , Yang Xiaona , Liu Fengzhong 
Published: September 2023

AbstractIn the digital era, digital innovation (DI) has become the first choice for many enterprises to create sustainable competitive advantage (SCA). How to effectively realize DI has become the focus of enterprises. Since ambidextrous learning (AL) provides two paths of knowledge acquisition, it can provide sufficient knowledge for corporate DI. However, this is not an easy task for small and medium enterprises (SMEs) given the dilemma of relatively scarce resources. Therefore, the aim of this study is to investigate whether AL can be a driving force for SMEs to build a SCA in the digital era. Meanwhile, this study intends to analyze the roles of DI and digital culture (DC) in the above relationship. Research data were obtained from leaders of 289 knowledge‐intensive SMEs in Nanjing, China. Through theoretical analysis and empirical testing, this study has obtained some findings. First, AL can be more effective in enhancing SMEs' SCA than exploratory or exploitative learning. Second, DI mediates the relationship between AL and SCA. Finally, DC can reinforce the mediating role of DI between AL and SCA. These findings reveal the influence mechanism between AL and SMEs' SCA in the digital era. In addition, this study helps us better understand how DI and DC operate within the above mechanism. Meanwhile, this study provides decision support for SMEs to establish SCAs in the digital era.
Synthetic cannabinoids in hair—Prevalence of use in abstinence control programs for driver's license regranting in Germany
Authors: Kutzler Johannes , Polettini Aldo Eliano , Bleicher Sergej , Sauer Christoph , Schultis Wolfgang , Neukamm Merja A. , Auwärter Volker 
Published: September 2023

AbstractAlthough the use, structural variety, and prevalence of synthetic cannabinoids (SCs) have steadily increased on the drug market, they are rarely analyzed in abstinence control programs for driver's license regranting. The aim of this study was to determine the SC prevalence in these programs by analyzing hair samples collected between March 2020 and March 2021 from various regions in Germany, mainly Bavaria (40%). Specimens were analyzed quantitatively for drugs of abuse and qualitatively for 107 SCs. Hair samples were screened by liquid chromatography–tandem mass spectrometry (LC–MS/MS), and to search for unknown SC analogs, positive samples were additionally screened by liquid chromatography‐high resolution time of flight mass spectrometry (LC‐qTOF/MS). The analysis of 5097 hair samples resulted in 181 SC detections (3.6%), showing a wide range of 44 SCs, with up to 13 different compounds found in a single sample. The most prevalent compounds were 5F‐MDMB‐PICA and MDMB‐4en‐PINACA; furthermore, 10 new substances not initially covered by LC–MS/MS analysis were detected by LC‐qTOF/MS. The SC positivity rate was comparable to cocaine (5.4%) and amphetamine (2.6%). Only in 35 cases (0.7%), SC analysis was requested by the clients, highlighting the insufficient coverage of SC consumption in the studied collective. In summary, hair sample analysis proved to be a valuable tool to monitor the use of SCs. In order to keep pace with newly emerging SC analogs, an up‐to‐date analytical method is essential. Prospectively, SCs should be more routinely screened in hair analysis for abstinence control to avoid cannabis substitution by SCs.
“Ordinary days would be extraordinary”: The lived experiences of severe and enduring anorexia nervosa
Authors: Cummings Melinda Parisi , Alexander Robbi K. , Boswell Rebecca G. 
Published: September 2023

AbstractObjectiveApproximately 25% of individuals with anorexia nervosa (AN) experience a chronic form of the disorder, referred to as severe and enduring anorexia nervosa (SE‐AN). Although the classification of SE‐AN remains preliminary, there have been increasing calls for a harm reduction‐based, collaborative treatment model for these patients. To provide such care for patients with SE‐AN, it is critical to listen to and learn from their lived experiences.MethodPatients (N = 17) admitted to an inpatient eating disorders program who met initial criteria for SE‐AN completed semi‐structured interviews about the course of their illness and prior treatment episodes. Interviews were audio recorded and transcribed. Data were analyzed using an inductive, reflexive approach to thematic analysis that examined common themes within and across interviews.ResultsThree themes were identified focused on (1) the all‐encompassing nature of SE‐AN, (2) treatment experiences, and (3) living with chronic illness. Within these themes, there were subthemes. Overall, individuals noted clear insight about their condition, both negative and positive experiences with previous treatment, and hope for better quality of life despite their illness.DiscussionIndividuals with SE‐AN describe their illness as a chronic condition and hope for a harm reduction‐based treatment. Future work, including the lived experiences of individuals with SE‐AN, is important to build our understanding of the classification and clinical characteristics of SE‐AN and to develop treatment approaches that may best serve these individuals.Public SignificanceMany people with anorexia nervosa do not achieve a full recovery despite repeated treatment episodes throughout their lifespan. Understanding the lived experiences of individuals with SE‐AN may help to inform future treatment development efforts that could improve eating disorder and quality of life outcomes for these patients.
The characteristic large‐scale annual analysis by gender and age in heart failure patients: cohort for 10 years in Korea
Authors: Chun Kyeong‐Hyeon , Pak Haeyong , Kim Hyeongsoo , Jang Ji‐Yong , Lee Hancheol , Park Jong‐Kwan , Oh Seungjin , Yoon Se‐Jung 
Published: September 2023

AbstractAimsThe prevalence and incidence rate of heart failure (HF) continues to increase along with the aging of the population and the increase of ischaemic heart disease. The morbidity and mortality of HF are also on the rise in the industrialized countries; it can be a great public health problem. A detailed and accurate analysis of the demographical incidence and prevalence of HF is an important first step in predicting the occurrence of the disease in the future and proper preparing for prevention. Here, we aimed to analyse the annual prevalence and incidence of HF by gender and age using long‐term national health insurance service data in the Republic of Korea.Methods and resultsA total of 47 243 patients newly diagnosed with HF between 2006 and 2015 among nationally representative random subjects of 1 000 000 were included. The data of age and gender were analysed by year, and the total population information of the Ministry of Land, Infrastructure, and Transport of Korea was referred to compare the data of HF patients with the total population (2008–15). Over the decade from 2006 to 2015, the prevalence of HF patients showed tendency of increase (P < 0.001). The overall incidence rate was also gradually increasing (P < 0.001), but in women, it tended to decrease gradually. Women significantly accounted higher than the male group in incidence of HF over the period (54.6% vs. 45.4%, P < 0.001). The mean age at the time of diagnosis gradually increased (P = 0.002 for total, P = 0.001 for each gender). Total incidence was highest in 70s (27.22%), but males were the most in their 60s and females were in their 70s. Analysis of annual trend by age and gender distribution of HF incidence in men presented highest in the 50s–70s with a similar pattern annually, and the incidence is increasing more recently. Different from that of men, in the case of women, the incidence gradually increased with age in a similar annual pattern, peaking in their 70s and gradually decreasing in recent years.ConclusionsThe prevalence and incidence of HF are gradually increasing. It increased rapidly in their 50s and older. It showed an increased incidence of HF especially in men between their 50s and 70s, and more observation and caution for the management of the risk factors may be needed to prevent HF in the male group.
Increasing green footprints: Indications of transformations in the socio‐economic spaces of Bangladesh
Authors: Huda S. S. M. Sadrul 
Published: September 2023

AbstractIn recent decades, Bangladesh has seen significant environmental degradation and the loss of its GDP, which has had a detrimental effect on public health, agriculture, forestry, fisheries, industrial development, and environmental services. The unusually high temperatures, humidity, and unpredicted rainfall gave rise to disease like dengue and affecting peoples mental health. However, the government, as well as public and private groups, are undertaking some phenomenal efforts to help reduce environmental degradation and raise the number of green footprints. The objective of this article is to examine the green initiatives, strategies, and policies of Bangladeshi organizations in enhancing green footprints in the socio‐economic spaces, through comprehensive content analysis of various newspapers, journal articles, government reports, and company annual reports. The aim of this article is to trace out the evidences of change in the socio‐economic fabric of the society. The primary focus of the article on the environment friendly business activities, which eventually bring social changes. The article found that green HRM, green business, MFS, green corporate culture is increasingly been seen in the society, which indicate silent changes. Bangladesh has put regulations and programs into place to lessen carbon emissions and safeguard sensitive coastal areas. It is noteworthy for demonstrating a strong dedication to improving sustainable development and environmental preservation. Many organizations in Bangladesh have also received the prestigious Asia's Corporate Excellence and Sustainability Awards for their outstanding zeal to ensure positive environmental changes in the society. Moreover, large proportion of Bangladesh's energy mix comes from renewable energy sources, leading to the installed renewable energy capacity of 579 MW. Additionally, the government has announced plans on replacing traditional transport methods with electric or hybrid vehicles. Bangladesh has further solidified its position as the global leader in green garments factories, as the country has 176 such facilities that have received the USGBC's LEED accreditation. The article placed a strong emphasis on particular policy proposals, including the adoption of the circular economy, the digital economy, sustainable finance, car‐sharing systems, renewable energy sources in manufacturing and workplaces, and environmentally friendly practices in both public and private organizations.
Deep transfer learning from ordinary to capsule esophagogastroduodenoscopy for image quality controlling
Authors: Zhang Yaqiong , Zhang Kai , Ding Ying , Liu Shaoqun , Wang Meijia , Wang Xu , Qin Zhe , Zhang Xiaohong , Ma Ting , Hu Feng , Li Peng , Feng Li 
Published: September 2023

AbstractQuality controlling for capsule endoscopic images can be completed with the assistance of artificial intelligence, but the labeling process is time‐consuming. Domain adaption is a robust tool for cross‐domain learning to reach a consistent target. Current research aims to study the feasibility and effectiveness of domain adaption from ordinary endoscopic images to capsule endoscopic images in quality controlling. Dynamic adversarial adaptation network (DAAN) was trained to identify low‐quality images using ordinary endoscopic images with corresponding labels (source domain with supervision) and capsule endoscopic images without corresponding labels (target domain without supervision) so that image quality controlling can be transferred from ordinary to capsule endoscopic images. 62,850 images from capsule endoscopy and 17,434 images from ordinary endoscopy were included in developing deep learning models. In internal cross‐validation, DAAN achieved an average area under receiver operating characteristic curve (AUROC) of 0.8638 (95% confidence interval [CI] 0.6753–1.0000) in filtering low‐quality images for capsule endoscopic images, compared with CNN B/16 and L/32, which were also trained with ordinary endoscopic images with corresponding labels. 18,636 images from 355 patients who received capsule endoscopy were prospectively collected. The AUROC of DAAN reached 0.9471 (95% CI 0.9428–0.9511), which surpassed CNN (0.8570 and 95% CI [0.8529–0.8608]) and ViT (L/32: 0.8183 and 95% CI [0.8143–0.8220] and B/16: 0.7779 and 95% CI [0.7960–0.8036]). Domain adaption can complete image quality controlling task in capsule endoscopic images with the supervision of ordinary endoscopic images, whose quantity is smaller so that the annotation workload can be alleviated.
Sustainable eco‐friendly sub‐micron NaCl crystal powder‐assisted method to synthesize SiOx/C as anode materials originated from rice husk for lithium‐ion batteries
Authors: Lee Se Hun , Cho Youngseul , Jeon Young Pyo , Chang Yujin , Lee Kyu Sang , Hong Dongpyo , Jeon Ok Sung , Park Yongyeol , Yang Hyun Seo , Yoo Young Joon , Park Sang Yoon , Piao Yuanzhe 
Published: September 2023

AbstractIn the present study, we produced SiOx/C from rice husk by the NaCl sub‐micron crystal‐assisted synthesis method which can mitigate environmental degradation and hazards, simplify preparation, and improve electrochemical performance. During synthesis, NaCl induces catalytic graphitization, carbon activation, and amorphous silica formation. Moreover, it is only partially consumed and can be recrystallized and reused indefinitely. Our NaCl sub‐micron crystal powder‐assisted method created lithium‐ion batteries (LIBs) with rice husk‐derived SiOx/C anodes that exhibited a high initial charge/discharge capacity of 422.05/915.93 mAh∙g−1 at 0.05 A∙g−1 current density and stable cycling performance. In addition, the SiOx/C electrode produced by the NaCl micro‐crystal method had 333.96 mAh∙g−1 capacity at 0.05 A∙g−1 current density. By contrast, bare rice husk electrode exhibited a lower capacity of 333.96 mAh∙g−1at the same condition.image
Calibration of discrete element parameters for simulating wheat crushing
Authors: Wang Xuefeng , Wu Wenbin , Jia Huapo 
Published: September 2023

AbstractThe mechanical properties of wheat grains were measured and analyzed using discrete element software, which provided crucial data for their processing in a mill. The foundational Hertz–Mindlin model was used as a theoretical framework to evaluate the accumulation angle of wheat grains. The Plackett–Burman, steepest ascent, and Box–Behnken methods were utilized in a series of experiments, with the accumulation angle serving as the dependent variable. Targeting the actual angle of repose in the response surface, the optimal parameters were derived using the regression equations. These included a static‐friction coefficient of 0.3 between individual wheat grains, rolling‐friction coefficient of 0.04 for wheat–wheat interactions, static‐friction coefficient of 0.554 for wheat–tooth roller interactions, collision recovery coefficient of 0.5 for wheat–wheat collisions, collision recovery coefficient of 0.45 for wheat–tooth roller collisions, and rolling‐friction coefficient of 0.05 for wheat–roller interactions. Relying on the bonding contact model of Hertz–Mindlin, virtual uniaxial compression tests were conducted to calibrate the wheat grain bonding parameters. A regression equation for the critical load was subsequently generated using the critical load of the wheat grain bonding model as the response variable. The optimal parameters were calculated and incorporated into the EDEM model for computation, which resulted in a relative error of 1.6% between the calculated and observed values, confirming the accuracy and feasibility of the calibration method, suggesting that the calibrated parameters were accurate.
You make me anxious! Witnessing safety violations during the daily commute and at work leads to employee work withdrawal
Authors: Cho Seonghee , Kim Sooyeol , Lee Hun Whee , Li Zhuyi Angelina 
Published: September 2023

AbstractSafety literature has traditionally focused on identifying and managing risk factors that lead to safety outcomes (e.g., injuries, accidents, death) at work. The current study takes a new perspective on employee safety and proposes that safety‐related experience has more general work implications. Drawing on theories of stress coping and workplace anxiety, we test a mechanism on how employees’ daily experiences of safety threats are related to their work behavior via negative emotional reactions. Specifically, we focus on employees’ experiences of safety violations on the way to work and at work during the ongoing struggles with COVID‐19. Our daily diary study (Level 1 N = 778, Level 2 N = 84; office workers in South Korea) shows that experiencing safety violations during the daily commute and at work is associated with increased state health anxiety at work, which then translates into work withdrawal on that day. Furthermore, we introduce organizational safety climate as an important mitigating factor of this stress‐coping process, as such a climate can emphasize management's commitment to safety.