bluuebunny/crossref_metadata_2025_split huggingface dataset:
Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks
Authors: Díaz-Santiago Elena , Moya-García Aurelio A. , Pérez-García Jesús , Yahyaoui Raquel , Orengo Christine , Pazos Florencio , Perkins James R. , Ranea Juan A. G. 
Published: January 2025

IntroductionMost drugs fail during development and there is a clear and unmet need for approaches to better understand mechanistically how drugs exert both their intended and adverse effects. Gaining traction in this field is the use of disease data linking genes with pathological phenotypes and combining this with drugtarget interaction data.MethodsWe introduce methodology to associate drugs with effects, both intended and adverse, using a tripartite network approach that combines drug-target and target-phenotype data, in which targets can be represented as proteins and protein domains.ResultsWe were able to detect associations for over 140,000 ChEMBL drugs and 3,800 phenotypes, represented as Human Phenotype Ontology (HPO) terms. The overlap of these results with the SIDER databases of known drug side effects was up to 10 times higher than random, depending on the target type, disease database and score threshold used. In terms of overlap with drug-phenotype pairs extracted from the literature, the performance of our methodology was up to 17.47 times greater than random. The top results include phenotype-drug associations that represent intended effects, particularly for cancers such as chronic myelogenous leukemia, which was linked with nilotinib. They also include adverse side effects, such as blurred vision being linked with tetracaine.DiscussionThis work represents an important advance in our understanding of how drugs cause intended and adverse side effects through their action on disease causing genes and has potential applications for drug development and repositioning.
Investigation of the effectiveness of parent-child interaction therapy on adjustment and behavioral problems in children with subthreshold autism
Authors: Seçer İsmail , Ulaş Sümeyye , Tatlı Eda , Çimen Fatmanur , Bülbül Burcu , Tosunoğlu Beyzanur 
Published: January 2025

BackgroundAutism Spectrum Disorder (ASD) is an increasingly prevalent neurodevelopmental disorder. However, the number of children who exhibit subthreshold levels of ASD symptoms, significant enough to experience functional and adaptive difficulties, is also substantial. These children require early interventions, similar to those diagnosed with ASD, due to their exhibited adaptive and behavioral challenges. PCIT offers a unique opportunity for children and their parents exhibiting subthreshold ASD to address such challenges through its practices and techniques.AimThis study aims to assess the initial result effectiveness of standard PCIT on the adaptive skills and school refusal behaviors of children exhibiting subthreshold ASD, as well as on the levels of parental stress and caregiving burden. The study intends to test these effects and report the outcomes.MethodThis study is a case study, and it involves three children with subthreshold ASD symptoms and their parents. The therapy processes were conducted for approximately 1 year.ResultResults obtained from this study revealed that PCIT holds promising prospects for improving adaptive and interaction skills, reducing school refusal, and alleviating parental stress and caregiving burden among children exhibiting subthreshold ASD.DiscussionPCIT is considered a functional approach for children and parents demonstrating subthreshold ASD symptoms, besides interventions addressing diagnosed ASD children. It is suggested that future studies should evaluate the effectiveness and sustainability of PCIT through randomized controlled trials in the context of subthreshold ASD.
The impact of artistic sports on academic self-efficacy
Authors: Tian Yanyan , Wang Haiqing 
Published: January 2025

IntroductionArtistic sports have a more positive impact on adolescents on the basis of basic sports. This study delves into the beneficial effects of Artistic sports compared to basic sports in enhancing academic self-efficacy in college students, and investigates the mediating roles of mindfulness, social anxiety, and academic procrastination in this process.MethodsA questionnaire survey was conducted among students in some universities in Gansu Province, collecting a total of 1,976 online questionnaires, including 263 males and 1,713 females, with 1,543 participants in Artistic sports courses and 433 participants in basic sports. Data processing was carried out using SPSS 26.0 software and its plugin PROCESS.ResultsThe analysis results indicate significant differences in mindfulness, social anxiety, academic procrastination, and academic self-efficacy among different types of sports training (ps &lt; 0.05); significant correlations were found among all variables (ps &lt; 0.001). Sports training types can directly predict academic self-efficacy (β = 0.069, t = 3.155, p &lt; 0.01), further confirming that sports training types can directly predict academic self-efficacy. Moreover, mindfulness, social anxiety, and academic procrastination play a chain mediating role between Artistic sports and academic self-efficacy.DiscussionThese findings highlight the potential value of Artistic sports in enhancing academic self-efficacy and provide practical guidance for education policymakers, school administrators, teachers, parents, and students to promote adolescent academic and psychological health development. It is recommended to enhance the promotion and training of Artistic sports.
Dispositional mindfulness and psychological well-being: investigating the mediating role of meaning in life
Authors: Aldbyani Aamer , Wang Guiyun , Chuanxia Zhang , Qi Yanxia , Li Jiaojiao , Leng Jie 
Published: January 2025

IntroductionMindfulness has been widely recognized for its positive impact on various aspects of psychological well-being. Prior research has investigated the role of mindfulness in enhancing hope and life satisfaction as separate constructs. However, limited attention has been given to the simultaneous influence of mindfulness on both hope and life satisfaction and the underlying mechanisms that may explain these relationships. This study examines the role of dispositional mindfulness in fostering hope and life satisfaction concurrently and explores the potential mediating role of meaning in life in this relationship.MethodsA total of 1,766 Chinese college students from Shandong Xiehe University participated in the study. Participants completed the Mindful Attention Awareness Scale (MAAS) to assess dispositional mindfulness, the Adult Hope Scale (AHS) to measure hope, the Satisfaction with Life Scale (SWLS) to evaluate life satisfaction, and the Meaning in Life Questionnaire (MLQ) to assess their perceived meaning in life. Statistical analyses, including mediation analysis, were conducted to explore the relationships among these variables.ResultsThe findings indicated that meaning in life partially mediated the relationship between dispositional mindfulness and both hope and life satisfaction. Specifically, higher levels of dispositional mindfulness were associated with greater hope and life satisfaction, and this relationship was partially explained by increased perceptions of meaning in life.DiscussionThese results underscore the critical role of meaning in life as a mediator in the positive effects of mindfulness on psychological well-being. The findings suggest that interventions aimed at enhancing mindfulness may benefit from incorporating strategies to foster meaning in life, thereby amplifying their impact on hope and life satisfaction. This study advances our understanding of the mechanisms linking mindfulness to key indicators of psychological well-being and highlights the integrative role of meaning in life in these processes.
How coach leadership behavior influences athletes’ performance: the chain-mediated role of the coach-athlete relationship and psychological fatigue
Authors: Liu Rui , Wang Shanshan , Li Jun 
Published: January 2025

ObjectiveAthletes’ psychological quality and competitive level are deeply influenced by coaches’ leadership behavior. It is of far-reaching significance to systematically investigate the relationship between them for carrying out scientific training and improving athletes’ competitive level. This study aims to investigate the relationships among coach leadership behavior, the coach-athlete relationship, psychological fatigue, and athletes’ performance, providing insights into enhancing athletes’ sports performance.MethodsUsing simple random sampling, 556 athletes (44.60% female) were recruited from professional training teams in the Xinjiang and Shanxi provinces of China as the study sample. The sample includes 47 s-class national athletes, 276 first-class national athletes, 171 master-class athletes, and 62 international-level athletes. Data were collected through offline surveys using the Coach Leadership Behavior Scale, the Tennis Performance Scale, the Coach-Athlete Relationship Questionnaire, and the Athlete Psychological Fatigue Questionnaire.ResultsDemocratic leadership behavior, autocratic leadership behavior, training and instruction behavior, social support behavior, and positive feedback behavior are positively correlated with the “coach-athlete” relationship and athlete performance, and negatively correlated with psychological fatigue. The “coach-athlete” relationship and psychological fatigue can serve as both simple mediators and chain mediators between democratic leadership behavior, autocratic leadership behavior, training and instruction behavior, social support behavior, positive feedback behavior, and athlete performance.ConclusionThis study systematically explored the complex relationships among coach leadership behavior, the coach-athlete relationship, psychological fatigue, and athletes’ sports performance. The findings suggest that positive coach leadership behavior may contribute to the development of athletes’ performance. Furthermore, the study underscores the significance of the coach-athlete relationship and psychological fatigue as key mechanisms through which coach leadership behavior influences athletes’ sports performance.
Macrostructures and rhetorical moves in research articles in nanotechnology
Authors: Luo Xianqing , Ji Jiajie 
Published: January 2025

IntroductionNotwithstanding the fact that extensive studies focused on exploring generic structures in established disciplines, scant attention has been directed to macrostructures and rhetorical moves in RAs in some emerging disciplines.MethodsBased on a self-compiled corpus of 50 research articles (RAs) from five top ranking journals in the field of Nanotechnology, we explored the macrostructures and rhetorical moves in RAs in Nanotechnology.ResultsIt was found that (i) scientists in Nanotechnology have a propensity to employ a merged [R&amp;D] structure to immediately discuss and contribute new knowledge tentatively in the specific contextualised situation after research results were presented, (ii) Even though RAs in Nanotechnology largely follows IMRD structure by abiding writing conventions in the research world, disciplinary variations were found regarding the rhetorical structures, specifically, scientists in Nanotechnology tend to employ more moves and steps in establishing research niche, detailed description of research methods, suggesting future research, but less moves and steps related to promotional strategies (M3S4, M3S5, M3S6).DiscussionThe research results have significant implications for English for Academic Purposes (EAP) instructors to make informed choices by using disciplinary empirical-based decisions to guide novice writers and students at tertiary level to write RAs by following disciplinary conventions of research communities in Nanotechnology so as to avoid overgeneralization.
The relationship between spiritual well-being and fear of cancer progression in Iranian cancer patients
Authors: Goudarzian Amir Hossein , Mazhari Seyed Amirhossein , Sobhanian Pooria , Farhadi Bahar , Kalantari Soheyla , Taebi Mozhgan 
Published: January 2025

IntroductionThis study aimed to investigate the nuanced relationship between spiritual well-being and fear of cancer progression among individuals diagnosed with cancer.MethodsThe study was conducted in 2023 and utilized a predictive cross-sectional survey. A total of 398 cancer patients were recruited using convenience sampling. The Spiritual Well-Being Scale (SWBS) and the Fear of Progression (FOP) scale were used for data collection. Data analysis was performed using SPSS version 26, AMOS, and JASP to assess the reliability of the constructs and the potential relationship between the two main variables.ResultsThe mean age of the participants was 49.14 years (SD = 16.16, 95% CI: 47.55 50.74). All constructs demonstrated strong factorial validity and reliability. Simple linear regression analysis revealed that spiritual well-being significantly predicted fear of cancer progression (R2 = 0.064, F = 27, p &lt; 0.001).DiscussionThe findings indicated a significant relationship between spiritual well-being and fear of cancer progression. These results highlighted the interconnectedness of spiritual well-being and fear of cancer progression among cancer patients.
Outdoor activity time and depression risk among adults aged 40 years and older: a cross-sectional analysis of NHANES 2011–2018 data
Authors: Liu Kai , Guo Cheng , Xie Juan , Cheng Liming 
Published: January 2025

BackgroundDepression is a significant global public health issue, affecting millions worldwide. Outdoor activities have shown potential mental health benefits, but the specific mechanisms and influencing factors remain unclear.ObjectivesThis study aimed to investigate the association between time spent outdoors and depression risk among U.S. adults, with a focus on variations across age and ethnic groups.MethodsUsing data from the NHANES 2011–2018 survey, we analyzed 9,036 adults aged 20 years and older. Participants self-reported their outdoor activity time and depressive symptoms. Statistical analysis, accounting for various demographic and lifestyle factors, was employed to assess the relationship between outdoor activity and depression risk.ResultsSpending more time outdoors was associated with a 51% lower risk of depression (odds ratio: 0.51, 95% CI: 0.40–0.64). Subgroup analysis revealed that this association was particularly pronounced among adults aged 40 and older, as well as non-Hispanic whites and non-Hispanic blacks.ConclusionEncouraging outdoor activities may represent an effective public health strategy to reduce depression risk, particularly among middle-aged and older adults and specific ethnic populations. Public health policies should prioritize initiatives that encourage outdoor engagement, and future research is needed to explore the underlying mechanisms and population-specific responses to outdoor activity.
Depression, anxiety and its predictor among internally displaced person in metekel Ethiopia, 2023: using a structural equation model
Authors: Bekeko Solomon Debela , Nimani Teshome Demis , Darcho Samuel Demissie , Bayisa Feyisa Shasho 
Published: January 2025

IntroductionThese individuals face psychological and physical trauma, loss of jobs, and emotional isolation, which may lead to the development of depression and anxiety. In 2022, 120 countries had over 71 million IDPs, a 20% increase from the previous year. In sub-Saharan Africa, natural disasters accounted for 40% of all new IDPs worldwide.MethodAn institutional-based cross-sectional study was conducted in Ethiopia. A systematic random sampling method was used to select 997 respondents. Data were collected using a structured interview questionnaire. STATA Version 17 and Amos Version 21 were used for the analysis. Descriptive statistics were summarized using frequency, percentage, table, graph, chart, figure, and summary statistics. Structural equation modeling was employed to assess the relationship.ResultThe overall prevalence of depression and anxiety was 79.64% (95% CI: 77.02 82.03) and 74.62% (95% CI =71.83%, 77.23%) respectively. age (adjusted β = 0.0034, 95% CI: 0.0012, 0.0056), history of the death of a loved one (adjusted β = 0.132, 95% CI: 0.0803, 0.185), had formal education (β = -0.164, 95% CI: -0.229, -0.098) occupation other (adjusted β = -0.183, 95% CI: -0.261, -0.105), Not having medically confirmed mental illness (adjusted β = -0.185, 95% CI: (-0.325, -0.045), PTSD score (adjusted β = 0.0082, 95% CI: 0.0048, 0.012) associated with anxiety.ConclusionDisplacement medically confirmed mental illness, death of a loved one, and post-traumatic stress disorder (PTSD) significantly impact anxiety. Policymakers should provide greater access to mental health management and prevention services, and medical practitioners should understand the connection between depression and anxiety.
Empirical evidence for a process-based model of health-related quality of life using network analysis
Authors: Stogios Nicolette , Francis Troy , Peiris Rachel G. , Stanimirovic Aleksandra , Rac Valeria , Nolan Robert P. 
Published: January 2025

BackgroundHealth-related quality of life (HRQL) is the perceived impact of a medical condition on one's overall wellbeing. While contemporary assessments are structured to evaluate an individual's HRQL state, we propose a complementary process-based model, which is defined as an appraisal that evolves over time as it reflects and informs a self-regulatory process of adapting to dynamic changes in bio-psycho-social life domains. In support of this approach, we developed a novel HRQL assessment tool called the EUROIA: EvalUation of goal-diRected activities to prOmote wellbeIng and heAlth, which uses self-report data to assess the frequency with which individuals engage in a sample of goal-directed activities in pursuit of living well.MethodsWe conducted a network analysis to evaluate the hypothesis that the EUROIA subscales would demonstrate a meaningful pattern of associations with an established HRQL measure and associated indices of psychosocial functioning and efficacy in self-managing a chronic medical condition.ResultsThe EUROIA is associated with established indices of HRQL in a manner that is theoretically consistent with our process-based model. Stability coefficients (i.e., betweenness, closeness, and strength) of the analysis revealed high reliability for the network.ConclusionThis analysis provides support for the validation of a process-based approach to HRQL assessment, which is represented, in part, by the EUROIA. A process-based approach complements and expands conventional measures of HRQL by focusing on how a patient's capacity to engage in goal-directed activities for living well is affected by their medical condition.
Physical activity and happiness of college students: chain mediating role of exercise attitude and sleep quality
Authors: Li Kehan , Omar Dev Roxana Dev , Li Wenhao 
Published: January 2025

IntroductionThis study explores the role of physical activity, exercise attitude, and sleep quality in college students’ happiness, aiming to provide a theoretical basis for improving college students’ mental health.MethodsThe study employed a whole group sampling method, utilizing a physical activity level scale, exercise attitude scale, sleep quality scale, and happiness scale. A questionnaire survey was conducted with 1,308 college students from four universities in China.ResultsThe analysis yielded three key findings: (1) Physical activity significantly improves college students’ happiness, and this improvement can be achieved through direct and indirect effects. (2) Positive exercise attitude plays an important mediating role between physical activity and happiness, and a high level of exercise attitude can enhance happiness. In addition, the effect of physical activity on happiness is most significant through exercise attitude. (3) Although sleep quality did not significantly mediate the relationship between physical activity and happiness alone, it played a positive role in the chain mediation path of “physical activity → exercise attitude → sleep quality → happiness.”DiscussionThe discovery of the chain mediation path shows that physical activity not only affects happiness, but also indirectly affects college students’ happiness through the combined effects of psychological and physiological factors.
Comparison of modelled diffusion-derived electrical conductivities found using magnetic resonance imaging
Authors: Hakhu Sasha , Hu Leland S. , Beeman Scott , Sadleir Rosalind J. 
Published: January 2025

IntroductionMagnetic resonance-based electrical conductivity imaging offers a promising new contrast mechanism to enhance disease diagnosis. Conductivity tensor imaging (CTI) combines data from MR diffusion microstructure imaging to reconstruct electrodeless low-frequency conductivity images. However, different microstructure imaging methods rely on varying diffusion models and parameters, leading to divergent tissue conductivity estimates. This study investigates the variability in conductivity predictions across different microstructure models and evaluates their alignment with experimental observations.MethodsWe used publicly available diffusion databases from neurotypical adults to extract microstructure parameters for three diffusion-based brain models: Neurite Orientation Dispersion and Density Imaging (NODDI), Soma and Neurite Density Imaging (SANDI), and Spherical Mean technique (SMT) conductivity predictions were calculated for gray matter (GM) and white matter (WM) tissues using each model. Comparative analyses were performed to assess the range of predicted conductivities and the consistency between bilateral tissue conductivities for each method.ResultsSignificant variability in conductivity estimates was observed across the three models. Each method predicted distinct conductivity values for GM and WM tissues, with notable differences in the range of conductivities observed for specific tissue examples. Despite the variability, many WM and GM tissues exhibited symmetric bilateral conductivities within each microstructure model. SMT yielded conductivity estimates closer to values reported in experimental studies, while none of the methods aligned with spectroscopic models of tissue conductivity.Discussion and conclusionOur findings highlight substantial discrepancies in tissue conductivity estimates generated by different diffusion models, underscoring the challenge of selecting an appropriate model for low-frequency electrical conductivity imaging. SMT demonstrated better alignment with experimental results. However other microstructure models may produce better tissue discrimination.