bluuebunny/crossref_metadata_2025_split huggingface dataset:
Educating Nursing Students About Chronic Pain Management and Opioids
Authors: Sirjani Hedieh H. , Hawkins Janice E. , Kekeh Michele A. , Akpinar-Elci Muge 
Published: September 2023

Abstract

Background
Healthcare professionals' knowledge of safe use of opioids for chronic pain management is critical in preventing opioid abuse and overdose. Undergraduate curricula of health professional schools, including undergraduate nursing programs, need to improve and adopt a comprehensive educational plan regarding this issue.

Method
This study implemented and assessed an educational module on undergraduate nursing students' knowledge and attitudes regarding prescription opioids.

Results
The educational module improved nursing students' knowledge and attitudes. Students reflected positively on the module.

Conclusion
Undergraduate nursing students benefited from the educational module on prescription opioids and preferred to include a similar module in their undergraduate curricula.
A combined therapy of myo-inositol, d-chiro-inositol and l-methyl folate vs metformin improves women with polycystic ovarian syndrome (pcos): a randomized controlled trial
Authors: Parvez Saba , Hameed Aleena , Siddique Sadia , Zubair Amraha , Khan Auon Zaib , Mumtaz Hassan , Hasan Mohammad 
Published: September 2023

Introduction:
Cardiovascular diseases (CVDs) are a range of blood vessel and heart problems. Cardiovascular complications are any situations that may cause cardiac muscle injury. In terms of mortality rates, cardiovascular disease (CVD) ranks high. Our study’s primary objective was to examine the effect of polypill on future cardiovascular events in a sizable group of post-MI patients.

Methodology:
A single-blind, randomized controlled trial was done from June 2021 and July 2022. Randomization assigned 1104 patients (552 males and females) to either the polypill group (100 mg Aspirin, 40 mg Atorvastatin, and 10 mg Ramipril) or standard treatment group. The two sample student’s t- test and chi-square test were used to compare the groups.

Results:
People in the experimental group were found to age of 43.44±5.78 years old, while control group were 52.98±5.76 years old. Study group systolic blood pressure was 49.32±1.93 mm Hg, compared to control group’s 48.34±10.07 mm Hg. The average range for LDL levels mg/dl in the study group was 10.39, while control group ranged from 29.09 to 27.62. 165 patients (29.89%) died in study group & 247 (44.74%) patients had improved quality of life. 214 (38.76%) patients died in control group and only 127 (23%) patients had improved quality of life.

Conclusion:
Combination therapy has been shown to reduce the risk of vascular events and overall mortality in a clinical trial. Although it is important to use caution when interpreting treatment impact in observational studies, the findings of this investigation provide credence to the idea that combination therapy is beneficial.
Development and Psychometric Evaluation of the Children's Illness-Related Concerns Scale
Authors: Almulla Hebah A. , Lewis Frances Marcus , Oxford Monica L. 
Published: September 2023

Background
Despite the effect of maternal breast cancer on many children, there is no valid or reliable quantitative measure of the concern that children attribute to their mothers' disease, which constrains both science and clinical practice.

Objectives
This study aimed to develop and psychometrically evaluate the initial measures of child-reported, illness-related concerns associated with maternal cancer.

Methods
The study was conducted in three phases: scoping review, item extraction from a battery of items obtained from school-aged children about general issues related to their mothers' breast cancer, and testing of the three proposed structural models of these extracted items using confirmatory factor analysis. The scoping review yielded five categories of illness-related concerns: altered family routines, uncertainty, concerns about illness contagion, maternal death, and maternal well-being. To reflect these five categories, 18 items were extracted from a 93-item questionnaire completed by 202 school-aged children regarding their mothers' breast cancer. Next, three structural models were hypothesized to assess the construct validity of illness-related concerns: five-, three-, and one-factor models. Confirmatory factor analysis was used to test and compare the models.

Results
The five-factor model best fit the data, and each factor showed adequate internal consistency reliability. These findings align with the a priori five-factor model informed by the scoping review.

Conclusion
The results provide initial evidence of the construct validity of the 18-item Children's Illness-Related Concerns Scale, which can be used to assess children's concerns and inform future intervention studies.
Histological and Immunological Evaluation of the Osteogenic Effects of Compact Bone–Delivered Stem Cell on Spongiosis Bone in the Rat Zygomatic Arch Defect Model
Authors: Tatar Burak Ergün , Gelbal Caner , Uslu Can , Yılmaz Bengi , Tomruk Canberk , Uyanıkgil Yiğit , Akkoç Tunç , Bozkurt Mehmet 
Published: September 2023

Background
In stem cell applications, apart from bone marrow and adipose tissue, compact bone is also used as an alternative. However, studies on this subject are limited. In our study, we investigated the effect of stem cell derived from compact bone on rat zygomatic arch defect.

Methods
Fifteen rats were included in the study. Five rats were killed to obtain stem cells before the experiment. The rats were divided into 2 groups with 5 rats each. In group 1, compact bone–derived stem cell was applied. In group 2, adipose tissue–derived stem cell was applied. Right zygomatic arch defect was created in rats in both groups. Zygomatic bones were decellularized by cryosurgery. Stem cells were transferred to zygomatic bones. The number of stem cells, stem cell differentiation, and superficial markers obtained from the groups were examined. Histologically, cell structure, osteocyte count and osteopontin scores, elemental composition of the groups, percentages of resemblance to intact bone, osteocytes numbers, and cells were examined by electron microscopy of the bones in the groups after killing.

Results
The number of stem cells administered to the groups was 5 × 107 and 3.2 × 107 for group 1 and group 2, respectively (P > 0.05). Histologically, the morphology of the cells in group 1 was found to be healthier than group 2. The number of osteocytes was 97.56 ± 15.4 and 132.93 ± 10.8 in group 1 and group 2, respectively (P < 0.05). The osteopontin score was 3.47 ± 0.73 and 65 ± 0.64 in group 1 and group 2, respectively (P < 0.05). In the electron microscope examination, the morphologies of the cells in group 1 were seen more normal. The Ca/P ratio of the groups was 1.51 and 1.59 in group 1 and group 2, respectively (P > 0.05). Osteocyte counts were 10.7 ± 2.8 and 6.1 ± 1.2 in group 1 and group 2, respectively (P < 0.05). Morphological similarity percentages to normal bone were 88.4% and 79.6% in group 1 and group 2, respectively (P > 0.05).

Conclusion
Stem cells obtained from compact bone gave positive results in zygomatic arch defect. This method can also be used as an alternative in stem cell applications.
Exploring the Role of Central Venous Oxygen Saturation in the Evaluation and Management of Severe Hypoxemia in Mechanically Ventilated Patients
Authors: Kanj Amjad N. , Rovati Lucrezia , Zambrano Claudia Castillo , Marquez Alberto , Robbins Kellie , Puentes Gustavo Cortes , De Moraes Alice Gallo , Gajic Ognjen 
Published: September 2023

Abstract

Background
While central venous oxygen saturation (ScvO2) has been used as an endpoint for the treatment of circulatory shock, its role in guiding the evaluation and treatment of patients with severe hypoxemia remains to be assessed. The aim of this study was to assess the incidence of low ScvO2 in a cohort of hypoxemic patients and the association of this finding with differences in clinical management and patient outcomes.

Methods
Retrospective review of data from adult ICU patients with hypoxemia who required invasive mechanical ventilation for over 24 hours and had at least one ScvO2 measured within 6 hours of a PaO2/FiO2 ratio < 200.

Results
Of 442 mechanically ventilated patients with severe hypoxemia, 249 (56%) had an ScvO2 < 70%. When compared to patients with ScvO2 ≥ 70%, those with low ScvO2 had worse systemic oxygenation and hemodynamic parameters and were more likely to receive RBC transfusions (31.7% vs 18.1%, p = 0.001), epinephrine (27.3% vs 16.6%, p = 0.007) and inodilators. Outcomes such as median ICU length of stay (7.5 vs 8.3 days, p = 0.337) and hospital mortality (39.8% vs 35.7%, p = 0.389) were not different between groups. When stratified by the central venous-to-arterial CO2 difference (∆PCO2), patients with a low ScvO2 and normal ∆PCO2 had lower median PaO2 and hemoglobin levels and received more RBC transfusions, while those with an increased ∆PCO2 had a lower pulse pressure and cardiac index and were more likely to receive epinephrine and milrinone.

Conclusion
Low ScvO2 is frequently observed in mechanically ventilated patients with severe hypoxemia, and these patients receive different interventions. Clinicians often use therapies targeting systemic oxygen delivery to correct low ScvO2. Prospective research is needed to identify patients with severe hypoxemia that might benefit from interventions targeting systemic oxygen delivery.
CLINICAL UTILITY OF INTERLEUKIN-1 INHIBITORS IN PEDIATRIC SEPSIS
Authors: Manchikalapati Ravi , Schening Jonathon , Farias Andrew J. , Sacco Keith A. 
Published: September 2023

ABSTRACT
The pathophysiology of pediatric sepsis is characterized by increased innate immune activation earlier in life. Interleukin-1 is a proinflammatory cytokine implicated in the pathophysiology of sepsis, and ferritin is a stable surrogate biomarker for elevated IL-1 levels. Data in adult sepsis have shown that use of anakinra, an anti–IL-1 receptor antagonist, led to improved clinical outcomes in patients with features of macrophage activation and hyperferritinemia. However, data in pediatric sepsis are lacking. Our narrative review sought to highlight the current understanding of using IL-1 inhibitors in pediatric sepsis. We identified five studies including one case report and four retrospective case series that described clinical outcomes in relation to use of anakinra for secondary hemophagocytic lymphohistiocytosis (HLH). A few patients in this pooled heterogenous cohort of 72 patients had concomitant infection meeting the criteria for sepsis. All studies measured ferritin levels and reported a decrease in ferritin after initiating anakinra. Twelve patients died after treatment initiation. There was no clear comparison in clinical outcomes between infected and noninfected patients. The pathophysiology of pediatric sepsis suggests that there is a need for blinded clinical trials using targeted immunomodulation such as IL-1 inhibitors in pediatric sepsis cohort with an immunophenotype suggesting increased innate immune activation.
Bioinformatics analyses and experimental validation of ferroptosis-related genes in bronchopulmonary dysplasia pathogenesis
Authors: Luo Yifan , Zhang Zongli , Xi Shibing , Li Tao 
Published: September 2023

AbstractObjectiveWe aimed to study the involvement of ferroptosis in the pathogenesis of bronchopulmonary dysplasia (BPD) by conducting bioinformatics analyses and identifying and validating the associated ferroptosis-related genes to explore new directions for treating BPD.MethodsThe dataset GSE32472 on BPD was downloaded from the public genome database. Using R language, differentially expressed genes (DEGs) between the BPD and normal group were screened. In the present study, we adopted weighted gene correlation network analysis (WGCNA) for identifying BPD-related gene modules and ferroptosis-related genes were extracted from FerrDb. Their results were intersected to obtain the hub genes. After that, to explore the hub gene-related signaling pathways, the hub genes were exposed to gene ontology enrichment analysis. With the purpose of verifying the mRNA expression of the hub genes, a single-gene gene set enrichment analysis and quantitative reverse transcription polymerase chain reaction were conducted. Immune cell infiltration in BPD was analyzed using the CIBERSORT inverse fold product algorithm.ResultsA total of 606 DEGs were screened. WGCNA provided the BPD-related gene module darkgreen4. The intersection of DEGs, intramodular genes, and ferroptosis-related genes revealed six ferroptosis-associated hub genes (ACSL1,GALNT14,WIPI1,MAPK14,PROK2, andCREB5). Receiver operating characteristic curve analysis demonstrated that the hub genes screened for BPD were of good diagnostic significance. According to the results of immune infiltration analysis, the proportions of a cluster of differentiation (CD)8, CD4 naive, and memory resting T cells and M2 macrophage were elevated in the normal group, and the proportions of M0 macrophage, resting mast cell, and neutrophils were increased in the BPD group.ConclusionsA total of six ferroptosis-associated hub genes in BPD were identified in this study, and they may be potential new therapeutic targets for BPD.
Synthetic antifreeze glycoproteins with potent ice-binding activity
Authors: Deleray Anna C. , Saini Simranpreet S. , Wallberg Alexander C. , Kramer Jessica R. 
Published: September 2023

AbstractAntifreeze glycoproteins (AFGPs) are produced by extremophiles to defend against tissue damage in freezing climates. Cumbersome isolation from polar fish has limited probing AFGP molecular mechanisms of action and limited developing bioinspired cryoprotectants for application in agriculture, foods, coatings, and biomedicine. Here, we present a rapid, scalable, and tunable route to synthetic AFGPs (sAFGPs) usingN-carboxyanhydride polymerization. Our materials are the first mimics to harness the molecular size, chemical motifs, and long-range conformation of native AFGPs. We found that ice-shaping and ice-recrystallization inhibition activity increases with chain length and Ala is a key residue. Glycan structure had only minor effects and all glycans examined displayed antifreeze activity. The sAFGPs are biodegradable, non-toxic, and internalized into endocytosing cells. sAFGPs were found to be bystanders in cryopreservation of human red blood cells. Overall, our sAFGPs functioned as surrogates for bona fide AFGPs, solving a long-standing challenge in access to natural antifreeze materials.
The impact of leadership behaviors on startup's entrepreneurship in Vietnamese Southern areas in the time of Covid-19
Authors: Pham Thi-Hong-Diep , Le Quoc Hoi , Ho Huong 
Published: September 2023

PurposeThis paper examines the impact of leadership behaviors on startup's entrepreneurship in Vietnamese southern areas in the time of Covid-19.Design/methodology/approachThe paper uses OLS regression model to evaluate the impact of leadership behaviors on startup's entrepreneurship in Vietnamese southern areas. Besides, the paper also uses AHP method to identify the factors that influence leadership behaviors in startups in the context of economic shock like the Covid-19 pandemic.FindingsResults reveal that the transformational leadership behavior has a positive correlation with startup's entrepreneurship while the transactional and laissez-faire leadership behaviors are negatively related to startup's entrepreneurship. In addition, using AHP method, certain determinants of leadership behaviors in startups have been specified; among which, the most profound influencing factors are respectively hi-tech use (0.081), training policy (0.079) and check (0.78). In contrast, the factors with negligible impacts include recruitment policy (0.004) and culture (0.037) in startups in the context of economic shock like the Covid-19 pandemic.Research limitations/implicationsThis research only evaluates this impact in the Covid-19 times. In the future, comparisons between the time after the Covid-19 at traditional enterprises and state enterprises are to be done to clarify the difference of this impact.Practical implicationsBy using OLS model and AHP model with the data collected from 209 start-ups, the paper examines the impact of leadership behaviors on start-up's entrepreneurship in the time context of economic shock like the Covid-19 pandemic and propose some recommendations to enhance entrepreneurship in startups in the developing countries.Social implicationsThis study is a step forward in the entrepreneurship research branch that investigates the entrepreneurship issue from the perspectives of social and interpersonal processes. With the identification of the leadership behaviors’ role in shaping start-up's entrepreneurship come highly applicable implications towards the emergence of more effective entrepreneurial startups in the time of Covid-19 and this prevalent digital context.Originality/valueWith the identification of the leadership behaviors' role in shaping startup's entrepreneurship come highly applicable implications toward the emergence of more effective entrepreneurial startups in the time of Covid-19 and this prevalent digital context. This study is conducted to analyze the impact of leadership behaviors on startup's entrepreneurship in the southern areas of Viet Nam having the most startups but affected the most seriously by the Covid-19 pandemic, which has not research on this topic for startups in a developing country like Vietnam in the context of an economic shock.
Emotional intelligence and psychological capital as moderators in the relationship between employee commitment and work engagement: evidence from employees in banking from India
Authors: Narayanasami Sangeetha , Joseph Michael Sammanasu , Parayitam Satyanarayana 
Published: September 2023

Purpose
This study aims to empirically examine the effect of employee commitment (EC) (affective, normative and continuance) and emotional intelligence (EI) on work engagement (WE) (vigor, dedication and absorption). Furthermore, the moderating effects of psychological capital (PsyCap) and EI on strengthening WE are investigated.

Design/methodology/approach
A carefully crafted survey instrument was developed, and data were collected from 511 employees working in the banking sector in southern India. First, the psychometric properties of the measures were checked. Second, the results were analyzed using Hayes’ PROCESS macros.

Findings
The results indicate EC and EI positively predict WE; EI moderates the relationship between EC and WE; and PsyCap (second moderator) moderates the relationship between EI (first moderator) and EC influencing WE.

Research limitations/implications
This study’s limitations include the common method and social desirability biases inherent in any social science research based on surveys. However, the authors have taken adequate care to minimize these limitations. In addition, this study has several implications for practicing managers interested in enhancing WE.

Originality/value
The three-way interaction between EC, EI and PsyCap, which is investigated in this study, represents an original and unique contribution to this study. To the best of the authors’ knowledge, previous researchers have not done the moderated-moderation, especially in the context of a developing country such as India. This research advances the growing literature on EC and WE. Implications for theory and practice are discussed.
Benefits, barriers, and facilitators of developing B2B mobile applications
Authors: Asamoah Daniel Adomako , Dinsmore John Bowman , Swani Kunal 
Published: September 2023

Purpose
While few studies have examined business-to-business (B2B) mobile application (app) usage, none have examined the challenges in developing these technological assets. This study aims to examine B2B marketing executives’ perceptions regarding benefits, barriers and facilitators in app development.

Design/methodology/approach
A survey of 311 B2B marketing executives at selling firms in the USA was conducted to identify key themes related to the benefits, barriers and facilitators in developing B2B apps. The research featured “open-ended” questions exclusively, and advanced textual and thematic analysis of executives’ responses produced several key themes.

Findings
Results show that the perceived benefit of lowering customer servicing and costs drives development more so than trying to realize new revenue opportunities (e.g. “saving” vs. “making” money). Achieving internal buy-in/participation was perceived as a larger barrier than the commitment of financial resources. Additionally, training and education were viewed as the strongest facilitators of an app’s success over its design and functionality. Implications for B2B firms are discussed.

Research limitations/implications
The open-ended format of this research captures a greater breadth of perspectives at the expense of more granular analysis of any particular issue.

Originality/value
The themes generated from the responses offer novel insights into the benefits sought in developing an app, as well as the technological, organizational and environmental factors that act as barriers and facilitators. The open-ended format of this research captures a greater breadth of perspectives at the expense of a more granular analysis of any particular issue.
Property tax incentives to divorce strategically
Authors: Santolini Raffaella 
Published: September 2023

PurposeThe paper aims to examine the role played by property tax in influencing strategic decisions regarding marital separation and divorce in Italian municipalities.Design/methodology/approachThe empirical analysis is conducted on a sample of 6,458 Italian municipalities by applying the ordinary least squares (OLS) and instrumental variables (IVs) approaches.FindingsThe estimation results show a small increase in marital separations and divorces as the difference between the municipal secondary and primary home tax rate increases. Specifically, an increase of 1‰ in the property tax rate differentials is accompanied by an increase of six marital separations and four divorces per 1,000 inhabitants.Research limitations/implicationsThe main limitation of the analysis is that the strategic behavior of the married couple is inferred from econometric analysis with data aggregated at the municipal level. To investigate this phenomenon more precisely, it would be useful to have individual data collected by surveys on strategic divorce decisions due to property tax incentives.Originality/valueThis study contributes to the scant existing literature on the tax incentives for strategic divorce. It is the first study to empirically investigate the effects of property tax on separation and divorce decisions by investigating the Italian context. In Italy, a property tax was introduced in 1993, encouraging “false” divorces by spouses with a second home since the tax on the secondary home was set at a rate higher than that on the primary residence. Moreover, there were no tax deductions and no additional tax breaks on the secondary home, while they were established on the primary one. Higher property taxes and the absence of tax breaks on the secondary home may have encouraged a strategic behavior whereby many married couples filed for false separation and divorce in order to recover part of property tax rebates.