bluuebunny/crossref_metadata_2025_split huggingface dataset:
Von der Freiheit zur Befreiung, eine iberoamerikanische Perspektive
Authors: Mate Reyes 
Published: July 2023

Abstract
In der lateinamerikanischen Welt wird Freiheit als Befreiung verstanden. Worin liegt der Unterschied? Er liegt in dem Bewusstsein, dass Freiheit entsteht, wenn der Einzelne und die Gesellschaft die Widerstände überwinden, die sie behindern. Die zentrale Bedeutung des Begriffs der Befreiung in Vergangenheit und Gegenwart steht in engem Zusammenhang mit der Geschichte der kolonialen Abhängigkeit und der Emanzipation aus dieser. Die Größe des Romans Hundert Jahre Einsamkeit des Nobelpreisträgers Gabriel García Márquez besteht darin, dass er zeigt, wie die Kolonialisierung der Neuen Welt dazu führt, dass europäische Sichtweisen auf die Geschichte und Vorgeschichte Lateinamerikas übernommen werden. Um sich in der von den westlichen Ländern dominierten Geschichte zu verorten, mussten die lateinamerikanischen Länder ihre Sichtweisen verleugnen und sich an die Vorstellungen und Perspektiven der Eroberer und ihre Kulturen assimilieren. Dieses „Vergessen“ ist der Grund für viele spätere Schwierigkeiten und Identitätsprobleme. Um zu sich selbst zu kommen und sich selbst zu verwirklichen, gilt es, sich von diesen kolonialen Zumutungen zu befreien.
A Dive into the Depths of Human Intimacy
Authors: João Name José , Baitello Junior Norval 
Published: July 2023

Abstract
This article is a report on ongoing field research and the exponential growth of the environment in which sex workers, prostitutes, call girls, and escorts operate. We look at the complexity of the conditions of such work and consider the socio-psychological and media vectors that make up the context from which its actors and stereotypes emerge. With the explosion of websites offering virtual or real sex, there is also a continuation of oppressive and violent male practices in this sector, restricting the freedom of choice for women who work professionally in this field. These practices reproduce the power relations and the exclusion that has always been present in society, and are also now more diffuse as virtual reality has come to play an important role in social practice.
Stability control in a helicoidal spin–orbit-coupled open Bose–Bose mixture
Authors: Kong Chao , Yin Bin , Wu Jiaxin , Huang Jianquan , Lei Dajun , Jiang Chunzhi , Deng Haiming 
Published: July 2023

Abstract
In this article, the modulation instability (MI) of open Bose–Bose mixtures with helicoidal spin–orbit coupling (SOC) was studied. Unlike previous spin–orbit (SO)-coupled Bose–Einstein condensate system with helicoidal gauge potential, the purpose of this article to study the input of the helicoidal SOC in the emergence of MI in open Bose–Bose mixtures by taking into account the Lee–Huang–Yang corrections to the coupled Gross–Pitaevskii equations. We present the detailed analyses of system parameters on the characteristics of MI and analytically conclude the parameter conditions for MI occurrence. Our results provide a potential way to manipulate the MI in the helicoidal SO-coupled open Bose–Bose mixtures.
Developing Drawing-Cartoon Class Assisted by Google Classroom in Gold Pencil Community
Authors: Arif Abdul , Utanto Yuli , Ahmadi Farid , Wibawanto Hari 
Published: July 2023

This online drawing-class research and development in Gold Pencil Community will answer the problems during this time. Gold Pencil has a regeneration mission, but they also have some constraints, such as time limitation and the lack of teaching material based on competency in implemented-learning activities. The aim of this research and development is to produce an online-learning design that suits to Gold Pencil needs. This research uses Sugiyono’s 10-steps model. These steps contain of (1) potency and problems, (2) data collection, (3) product design, (4) design validation, (5) trial use, (6) product revision, (7) product trial, (8) design revision, (9) product revision, and (10) production. The steps mentioned are modified into 3 main steps, namely planning, development and testing. The result of this research is an online-learning design of drawing cartoon assisted with Google Classroom for beginner cartoonists. This online-learning design can help Gold Pencil Community to realize the mission of regeneration through learning activities. The results of this research and development also can be another community’s alternative, especially for people who want to explore cartoon.
On the Dirichlet problem for de ge nerate Beltrami equations
Authors: Gutlyanskiĭ V.Ya. , Ryazanov V.I. , Sevost’yanov E.A. , Yakubov E. 
Published: July 2023

We study the Dirichlet problem as with continuous boundary data in arbitrary simply connected bounded domains D of the complex plane where f satisfies the degenerate Beltrami equation a. e. in D. We give in terms of the BMO and FMO criteria as well as a number of other integral criteria on the existence and representation of regular discrete open solutions to the stated above problem.
Взаємодія пропоксазепаму з ізоформами цитохрому P450 за результатами молекулярного докінг-аналізу
Authors: Ларіонов В.Б. , Головенко М.Я. , Кузьмін В.Є. , Валіводзь І.П. , Нефьодов О.О. 
Published: July 2023

Методи комп’ютерного моделювання дають можливість оптимізувати процес попередньої оцінки потенціалу взаємодії майбутніх лікарських засобів. Авторами використано моделювання in silico для прогнозування та пояснення можливої взаємодії пропоксазепаму з ізоферментами CYP на молекулярному рівні. Для розрахунку вільної енергії взаємодії та визначення амінокислотних залишків процедурою молекулярного докінгу було застосовано програму iGEMDOCK v2.1, досліджувані ензими — комплекси ізоформ CYP із референтними лігандами (1A2 (2hi4), 2B6 (5uda), 2C8 (2nnj), 2C9 (1og5), 2C19 (4gqs), 2D6 (4wnu) та 3A4 (5te8), молекулами-субстратами для кожного ізоензиму вибрано відповідно фенацетин, бупропіон, амодіахін, диклофенак, S-мефенітоїн, буфуралол та мідазолам з тестостероном відповідно.
Пропоксазепам має досить високі показники вільної енергії взаємодії з усіма ізоформами CYP (8,15—9,8 ккал/моль), однак є різниця в кількості спільних амінокислотних залишків, що беруть участь у взаємодії зі специфічними субстратами. За різницею енергії зв’язків можна припустити, що найменший конкурентний (інгібувальний) ефект пропоксазепам може мати відповідно на ізоформи 3A4 (із субстратом тестостероном) та 2D6. Аналіз взаємодій пропоксазепаму з різними ізоформами CYP з урахуванням їх індивідуальних субстратів дає підставу припустити можливість конкурентної взаємодії для 1А2, 2С19 та 2С8 і, меншою мірою, для 2С9, 3А4 та 2B6. Також можна очікувати, що пропоксазепам може бути субстратом для досліджуваних ізоформ цитохрому.
“E agora, o que eu faço?”: reflexões sobre os efeitos da pandemia na vida e saúde mental de estudantes universitárias/os em início, meio e final de curso
Authors: Romanini Moises 
Published: July 2023

Objetivo: problematizar os impactos da pandemia e do ensino remoto na vida de estudantes universitárias/as, considerando algumas especificidades em relação ao momento do curso, a partir de uma experiência promovida por um projeto de extensão que nos colocou em contato direto com estudantes de nossa universidade. Método: estudo de caso do Grupo Virtual MEDUSA, ação do Projeto de Extensão “Movimento Educação e Saúde Mental – MEDUSA”, desenvolvido na Universidade Federal do Rio Grande do Sul. Entre 2020 e 2021, foram realizados 45 encontros de aproximadamente uma hora e trinta minutos, totalizando mais de 60 horas registradas em diários de campo, com a participação de mais de 80 estudantes. É a partir destes fragmentos de escuta e de escrita, que o estudo de caso se constitui. Resultados: foram identificados efeitos na vida e saúde mental das/os estudantes, tais como dificuldades com as práticas de ensino e aprendizagem online; o excesso de atividades e sensação de esgotamento; ambientes inadequados de estudo; o sentimento de solidão e desânimo decorrentes da falta de conexão social; sintomas de estresse, ansiedade e depressão; polarização política e negacionismo científico (o que tem gerado, por exemplo, conflitos familiares significativos); em decorrência desse, insatisfação com a ausência de engajamento coletivo na pandemia (o que torna ainda mais imprevisíveis os efeitos da pandemia e o tempo necessária para a volta às aulas presenciais); dentre outros. Os efeitos são sentidos de formas singulares também conforme o período do curso em que a/o estudante se encontra. Considerações finais: para enfrentar todos os desafios, precisamos construir mais espaços de escuta e diálogo com as/os estudantes, utilizando as redes internas como centros ou núcleos de apoio aos estudantes, que compõem a estrutura institucional, mas também inventando espaços dentro dos cursos de graduação, com professoras/es, técnicos-administrativos e estudantes.
Realidade de serviços e da assistência em saúde após acometimento pela covid-19: uma revisão integrativa de literatura
Authors: Beatriz Frantz Krug Suzane , Ziembowicz Henrique , Cesar de Almeida Bavaresco Iagro , Schmidt Rizzi Laura , Souza Irene , Pappen Morgana , Mocelin Guilherme 
Published: July 2023

Introdução: o surgimento da Covid-19 causada pelo Sars-COV-2, ao final do ano de 2019, produziu, nos diversos âmbitos da gestão pública, dos serviços e na assistência em saúde, adaptações, melhorias e também algumas limitações ainda não bem dimensionadas. Objetivo: sistematizar dados da produção científica nacional e internacional acerca da realidade dos serviços e da assistência à saúde prestada à população, após o acometimento pela Covid-19. Método: estudo de revisão integrativa da literatura com busca dos artigos publicados entre janeiro a setembro de 2021, na base de dados Portal de Periódicos da CAPES, utilizando os Descritores em Ciências da Saúde (DeCS) “Covid-19”, “serviços de reabilitação”, “atenção à saúde” e “assistência integral à saúde” e seus equivalentes em língua inglesa. Foram encontrados 234 artigos, sendo que artigos duplicados, em outra língua, os que não abordavam a temática, artigos de revisão e meta-análise foram excluídos, resultando em três estudos selecionados. A análise dos dados foi realizada por meio da Análise de Conteúdo, com a elaboração de três campos temáticos: (re) estruturação de fluxos e processos de trabalho; saúde e segurança dos trabalhadores da saúde; modelos de assistência à saúde. Resultados: os artigos selecionados abordavam questões relacionadas à necessidade de alterações e adaptações nos serviços de saúde, acerca dos atendimentos assistenciais nos casos de Covid-19, como também medidas de promoção da saúde, prevenção do risco de contágio da doença e proteção dos trabalhadores da saúde, além de reformulações necessárias nos padrões de assistência à saúde dos pacientes. Considerações finais: buscou-se dar visibilidade ao tema em questão, reforçando a necessidade de investigações científicas a respeito, considerando a pequena quantidade de estudos encontrados no contexto de pós- Covid-19 nos serviços e na assistência à saúde. Os resultados apontaram aspectos relacionados à necessidade de diversas modificações e adaptações dos serviços de saúde após o acometimento pela doença.
Caracterização de variantes patogênicas nos genes BRCA 1 e 2 e suas associações com câncer de próstata
Authors: Höehr Zwetsch Maria Eduarda , Marcon Kaspary Victoria , Dalla Lasta Frigeri Caroline , Pozzobon Adriane 
Published: July 2023

Objetivo: verificar em bases de dados as variantes patogênicas associadas aos genes BRCA 1 e 2 e sua associação com câncer de próstata e relacionar a ocorrência de variantes patogênicas nos genes BRCA 1 e 2 com a incidência e mau prognóstico do câncer de próstata. Método: foi realizada uma revisão bibliográfica na base de dados PubMed usando os descritores em inglês e português: mutation (mutação), BRCA, prostate cancer (câncer de próstata) cruzados aleatoriamente nos últimos 10 anos. Resultados: foram encontrados 132 artigos específicos com o as palavras, destes 11 artigos preencheram os critérios de inclusão. A partir dos dados coletados, observou-se uma associação nas variantes patogênicas do BRCA 1 e 2 com câncer de próstata (CaP). A prevalência das mutações entre BRCA1 e BRCA2 divergiu conforme os artigos, sendo mais frequentes mutações deletérias nos genes em questão. Contudo todas foram fortemente associadas ao CaP e mau prognóstico. Considerações finais: apesar de a literatura divergir entre as prevalências e tipos das mutações, devido à variações metodológicas e características da amostra, é importante a realização de pesquisas bibliográficas que avaliam o impacto das variantes patogênicas BRCA 1 e 2 no manejo do paciente com câncer de próstata, já que a presença está associada a um mau prognóstico.
Non-invasive brain stimulation for the treatment of neurological and psychiatric disorders and for improving physical performance: protocol of umbrella reviews
Authors: Shirahige Lívia , Baptista Abrahão , Sá Kátia Nunes , Baltar Adriana , Marques Déborah , Carneiro Maíra Souza , Brito Rodrigo , Tanaka Clarice , Oda Adriana Leico , Okano Alexandre , Brunoni André , Monte-Silva Kátia , Working Group NAPeN 
Published: July 2023

Background: With the increasing meta-analysis studies of noninvasive brain stimulation (NIBS) a major review has become a logical step to provide evidence to support decision-makers. Objective: Umbrella reviews of the Working-Group of NAPeN Network (a Brazilian scientific network for NIBS development) will summarize the results of existing evidence in meta-analysis with focus on NIBS techniques applied for clinical settings, exercise and sports science. Methods and materials: Firstly, a screening was performed to identify meta-analysis in which NIBS were applied to neurological and psychiatric disorders and healthy subjects. A second literature search was conducted in the Pubmed using a PICO-question for each population and NIBS techniques found in the first search. Methodological quality and certainty of evidence will be evaluated using the AMSTAR 2 and GRADE framework, respectively. Partial results: After the first search, we found meta-analyses including repetitive transcranial magnetic stimulation and transcranial direct current stimulation, applied in populations with neurological (cerebral palsy, chronic pain, dementia, epilepsy, essential tremor, multiple sclerosis, Parkinson’s disease, tinnitus, tourette syndrome, and stroke) and psychiatric disorders (anxiety, attention-deficit hyperactivity, autism spectrum, obsessive-compulsive and post-traumatic stress disorders, schizophrenia, craving/addiction and depression), and in healthy subjects. A total of 118 meta-analyses will be included in the qualitative review. The results of evidence were identified in the outcomes of six umbrella reviews. Conclusion: Evidence of therapeutic and nontherapeutic use of NIBS techniques will support experts to produce consensus statements and assist professionals in making decisions of incorporating or not NIBS into clinical practice.
Meaningful Learning and Mathematical Modelling - Contributions to Dealing with Business Problem Situations in Higher Education
Authors: Fontana Arrigo , Groenwald Claudia Lisete Oliveira 
Published: July 2023

Background: Applying mathematical modelling in problem situations shows the possibility of observation of the existing meaningful learning as a learning environment for the construction of knowledge with problems situations of the professional daily life of students enrolled in the subject Operational Research of Fisul College Administration Course, at Serra Gaúcha, Rio Grande do Sul. Objectives: To elaborate, construct, and study a mathematical model that describes and/or explains these living situations in a professional routine integrated into the meaningful learning theory. Design: Qualitative research, based on the meaningful learning theory, in the operational research with the assistance of Solver and mathematical modelling. Setting and participants: The research was carried out in two classes of 24 students who attended the subject Operational Research in Higher Education. Data collection and analysis: The research was developed in five stages: Diagnostic Probing, Advanced Organizers, Evaluative Instrument, Modelling of Operational Research Problems, and Closure Activities. Results: Most students have evidence of the presence of subsumers in the activities developed, inserting concepts related to management, where they are related to the Business Administration course. Conclusions: The results revealed evidence of the Administrator’s professional conditions, such as the ability to recognise and define problems, introduce changes in the productive process, where the problems originated, and traces of construction of knowledge itself were perceived.
Comparative assessment of the exosomal tumor-associated microRNA levels in blood plasma and ascitic fluid in ovarian cancer patients
Authors: Dzhugashvili E. I. , Yunusova N. V. , Yalovaya A. I. , Grigorieva A. E. , Sereda E. E. , Kolomiets L. A. , Tamkovich S. N. 
Published: July 2023

Introduction. Ovarian cancer (OC) is one of the malignant neoplasms of the female reproductive system with a high mortality rate. Currently used tumor markers of this pathology do not have high sensitivity and specificity. In this regard, promising areas of molecular oncology are the study of the mechanisms of carcinogenesis of OC and the search for new biomarkers of liquid biopsy for early non-invasive diagnosis of neoplasms. It is known that tumor cells actively secrete exosomes into the extracellular space, which include biologically active molecules involved in carcinogenesis and claiming to be diagnostic markers. It was previously shown that microRNA-24 (miR-24) and microRNA-101 (miR-101) are transported as part of exosomes in OC and are involved in the degradation of the extracellular matrix, stromal remodeling, angiogenesis, and cancer cell motility.Aim. To evaluate the representation and diagnostic significance of miR-24 and miR-101 in plasma exosomes and ascitic fluid of OC patients.Materials and methods. The study included blood and ascitic fluid samples from OC patients (n = 20) and blood samples from healthy women (n = 19). The exosomal nature of the vesicles was confirmed by transmission electron microscopy, nanotracing analysis, and flow cytometry. After isolation of exosomal RNA, the relative level of miRNA was determined using reverse transcription and real-time polymerase chain reaction.Results. The highest concentration of exosomes was found in the ascitic fluid of OC patients, while the concentration of exosomes in the blood plasma of these patients was significantly higher than in healthy women. Relative levels of miR-24 and miR-101 in exosomes of blood plasma of healthy women were significantly higher than in exosomes of blood plasma and ascitic fluid of OC patients; at the same time, the levels of these miRNAs in exosomes of plasma and ascitic fluid of patients did not differ significantly.Conclusion. The results obtained confirm the promise of exosomal miR-101 and miR-24 for the diagnosis of OC by liquid biopsy.
Mechanisms of action of plant polyphenols on the initiation of carcinogenesis
Authors: Lyubitelev A. V. , Sivkina A. L. , Vlasova O. A. , Belitsky G. A. , Studitsky V. M. 
Published: July 2023

Genetic apparatus of human cells is constantly affected by a broad spectrum of mutagenic factors, both exogenous and endogenous. Genetic and epigenetic disorders, which emerge as a result of this influence, become the main cause of the majority of malignant neoplasias. Several different approaches were proposed to prevent these disorders, including the suppression of the activity of mutagenic factors by treatment with certain chemical compounds. Plant polyphenols are promising candidates for the development of chemopreventive drugs, as they exert the ability to regulate the metabolic activation of procarcinogens and modulate the cellular oxidative stress. In the present review, classification of plant phenolic compounds and their interactions with biological macromolecules are described, along with the molecular mechanisms of their influence on the enzymes and regulatory pathways of phase I xenobiotic metabolism, and the prevention of oxidative stress. Interactions between natural polyphenols and patient’s microbiota is also described.
Cell-free plasma miRNAs analysis for low invasive lung cancer diagnostics
Authors: Konoshenko M. Yu. , Laktionov P. P. , Lancuhaj Yu. A. , Pak S. V. , Krasilnikov S. E. , Bryzgunova O. E. 
Published: July 2023

Introduction. The high mortality rate in patients with lung cancer (LC) is due to the lack of highly sensitive diagnostic markers of this disease. Genetic and epigenetic alterations in tumor cells, for example, aberrant microRNA expression, can be proposed. It is known that extracellular/circulating microRNA of biological fluids, in complexes with proteins, or packaged in extracellular vesicles is of interest for the diagnosis of tumor diseases.Aim. To perform a comparative analysis of miRNA expression in plasma and plasma extracellular vesicles of LC patients and healthy donors. Based on the obtained results, to propose a diagnostic panel to identify patients with LC.Materials and methods. Blood plasma was obtained from blood samples of healthy donors and LC patients by sequential centrifugation. Then, a fraction of extracellular vesicles (40–150 nm in size) was isolated from a part of the obtained plasma supernatant by the method of aggregation-precipitation with polyethylene glycol/blue dextran. MicroRNAs were isolated from both blood plasma fractions of patients and healthy donors using guanidine isothiocyanate and octanoic acid. Expression of 17 miRNAs most characteristic for the development of LC according to our and literature data in the above-mentioned blood plasma fractions was analyzed by stem-loop reverse transcription polymerase chain reaction.Results. 29 and 10 miRNA pairs were differentially expressed in plasma extracellular vesicles and plasma of lung cancer patients and donors. Thus, plasma extracellular vesicles are characterized by greater potential as a source for miRNA based lung cancer diagnostic panels in comparison with blood plasma. Diagnostic algorithm based on aberrant miRNA expression of 8 different miRNAs (miRNA-30e, -1, -125b, -133, -222, -374, -425, -660) composed in 6 pairs was designed. This algorithm allows to diagnose 100 % of patients with lung cancer stages II–IV.Conclusion. Extracellular plasma vesicles represent a promising source of diagnostically significant microRNAs compared to plasma microRNAs. For the diagnosis of patients with non-small cell lung cancer with 100 % sensitivity and specificity, a panel of 8 microRNAs (6 miRNA pairs) was proposed.