bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer-associated fibroblasts promote malignant phenotypes of prostate cancer cells via autophagy
Authors: Liu XuKai , Tang JiZu , Peng LiQiang , Nie HaiBo , Zhang YuanGuang , Liu Pan 
Published: April 2023

AbstractDysregulation of autophagy in cancer-associated fibroblasts (CAFs) has been demonstrated to play a role in malignant phenotypes of human tumors. We intended to investigate the function of CAFs autophagy in prostate cancer (PCa). Firstly, CAFs and normal fibroblasts (NFs) were isolated from cancerous and adjacent normal tissues of PCa patients, for the following experimental preparation. In comparison with NFs, CAFs expressed higher levels of the myofibroblast marker ?-smooth muscle actin (?-SMA) and the mesenchymal marker Vimentin. Besides, CAFs possessed a higher autophagic level than NFs. As for malignant phenotypes, PCa cells co-cultured with CAFs-CM showed greater proliferation, migration and invasion capabilities, while these outcomes were obviously abolished by autophagy inhibition with 3-Methyladenine (3-MA). Moreover, silencing of ATG5 in CAFs inhibited fibroblasts autophagic level and suppressed malignant phenotypes of PCa cells, while ATG5 overexpression in NFs exerted opposite effects. Depletion of ATG5 in CAFs inhibited the xenograft tumor growth and lung metastasis of PCa cells. Taken together, our data demonstrated the promotive effect of CAFs on PCa malignant phenotypes through ATG5-dependent autophagy, suggesting a novel mechanism for PCa progression.
Detecting Greenwashing! The Influence of Product Colour and Product Price on Consumers’ Detection Accuracy of Faked Bio-fashion
Authors: Ende L. , Reinhard M.-A. , Göritz L. 
Published: April 2023

AbstractWhile there exists recent research about greenwashing in the context of branding and product packaging as well as advertising, we investigated greenwashing detection depending on the cues colour and price of the product itself. We hypothesized: The more the product cues fit to the mental representation of the corresponding category-prototype of bio (or non-bio) products, the more likely consumers classify the product to that category, are confident with the classification-decision and actually get deceived. In two studies, female consumers were asked to classify actual bio and actual non-bio fashion products from online shops as bio or faked bio. The bio-typicality of the colour of the product (Studies 1 and 2) and the price-level of the product (Study 1) were systematically varied. According to our assumptions, the probability to classify a product as bio or non-bio was higher when these product cues fitted to the expected status of the product. Furthermore, consumers reached higher classification accuracy when the colour (and the price) of the product fitted the actual status of the product. Unexpectedly, effects were independent from consumers’ varying ecological context experience. Concluding, consumers got “successfully” greenwashed by just a bio-typical product colour and a high price what highlights the importance of stronger political regulations in the B2C sales market.
Beyond job placement: careers for refugees
Authors: Arthur Nancy , McMahon Mary , Abkhezr Peyman , Woodend Jon 
Published: April 2023

AbstractIn this article, we highlight the Australian country context to advocate for career support that extends beyond initial job placement in a segmented labor market to strengthen refugees’ skills and knowledge and future career development. We address systemic barriers while advocating for access to skilled career development practitioners, whose important expertise as members of multidisciplinary teams could enhance resettlement assistance. Strengthening the preparation of career development practitioners is essential for providing career support to refugees and for building capacity in the provision of resettlement services. We encourage debate within and between country contexts about ways to enhance refugees’ career development.
The underlying career values of young adults’ protean and traditional career orientations
Authors: Kim Sujin , Hood Michelle , Creed Peter A. , Bath Debra 
Published: April 2023

AbstractAlthough young people espouse a range of career values, the extent to which traditional career values inter-mix with protean values is unclear. We interviewed a group of young university students in Australia (N = 24,MAge19.4 years; 50% young men) and examined the full range of traditional and protean values held. Employing applied thematic analysis, we found that freedom/autonomy and fit to self were dominant in protean career themes, while they strongly expressed a desire for job security in a traditional career. The results inform theory development in the career development area and can assist university career counselors.
Hearing loss classification algorithm based on the insertion gain of hearing aid
Authors: Guo Ruxue , Liang Ruiyu , Wang Qingyun , Zou Cairong 
Published: April 2023

AbstractHearing loss is one of the most prevalent chronic health problems worldwide and a common intervention is the wearing of hearing aids. However, the tedious fitting procedures and limited hearing experts pose restrictions for the popularity of hearing aids. This paper introduced a hearing loss classification method based on the insertion gain of hearing aids, which aims to simplify the fitting procedure and achieve a fitting-free effect of the hearing aid, in line with current research trends in key algorithms for fitting-free hearing aids. The proposed method innovatively combines the insertion gain of hearing aids with the covariates of patient’s gender, age, wearing history to form a new set of hearing loss vectors, and then classifies the hearing loss into six categories by unsupervised cluster analysis method. Each category of representative parameters characterizes a typical type of hearing loss, which can be used as the initial parameter to improve the efficiency of hearing aid fitting. Compared with the traditional audiogram classification method AMCLASS (Automated Audiogram Classification System), the proposed classification method reflect the actual hearing loss of hearing impaired patients better. Moreover, the effectiveness of the new classification method was verified by the comparison between the obtained six sets of representative insertion gains and the inferred hearing personalization information.
Patient-reported outcomes in refractory hormone-producing pituitary adenomas: an unmet need
Authors: van Trigt Victoria R. , Pelsma Iris C. M. , Biermasz Nienke R. 
Published: April 2023

AbstractPurposeTo describe quality and outcomes of patient-reported outcome (PRO) measures (PROMs) used in patients with refractory hormone-producing pituitary adenomas, and to provide an overview of PROs in these challenging pituitary adenomas.MethodsThree databases were searched for studies reporting on refractory pituitary adenomas. For the purpose of this review, refractory adenomas were defined as tumors resistant to primary therapy. General risk of bias was assessed using a component approach and the quality of PROM reporting was assessed using the International Society for Quality of Life Research (ISOQOL) criteria.Results20 studies reported on PROMs in refractory pituitary adenomas, using 14 different PROMs, of which 4 were disease specific (median general risk of bias score: 33.5% (range 6–50%) and ISOQOL score: 46% (range 29–62%)). SF-36/RAND-36 and AcroQoL were most frequently used. Health-related quality of life in refractory patients (measured by AcroQoL, SF-36/Rand-36, Tuebingen CD-25, and EQ-5D-5L) varied greatly across studies, and was not always impaired compared to patients in remission.ConclusionThere is a scarcity of data on PROs in the subset of pituitary adenomas that is more difficult to treat, e.g., refractory and these patients are difficult to isolate from the total cohort. The patients' perspective on quality of life, therefore, remains largely unknown in refractory patients. Thus, PROs in refractory pituitary adenomas require adequate analysis using properly reported disease specific PROMs in large cohorts to enable appropriate interpretation for use in clinical practice.
Ecological rationality and economics: where the Twain shall meet
Authors: Ortmann Andreas , Spiliopoulos Leonidas 
Published: April 2023

AbstractOver the past decades psychological theories have made significant headway into economics, culminating in the 2002 (partially) and 2017 Nobel prizes awarded for work in the field of Behavioral Economics. Many of the insights imported from psychology into economics share a common trait: the presumption that decision makers use shortcuts that lead to deviations from rational behaviour (the Heuristics-and-Biases program). Many economists seem unaware that this viewpoint has long been contested in cognitive psychology. Proponents of an alternative program (the Ecological-Rationality program) argue that heuristics need not be irrational, particularly when judged relative to characteristics of the environment. We sketch out the historical context of the antagonism between these two research programs and then review more recent work in the Ecological-Rationality tradition. While the heuristics-and-biases program is now well-established in (mainstream neo-classical) economics via Behavioral Economics, we show there is considerable scope for the Ecological-Rationality program to interact with economics. In fact, we argue that there are many existing, yet overlooked, bridges between the two, based on independently derived research in economics that can be construed as being aligned with the tradition of the Ecological-Rationality program. We close the paper with a discussion of the open challenges and difficulties of integrating the Ecological Rationality program with economics.
Electrochemical Scanning Tunneling Microscopy as a Tool for the Detection of Active Electrocatalytic Sites
Authors: Schmidt Thorsten O. , Haid Richard W. , Gubanova Elena L. , Kluge Regina M. , Bandarenka Aliaksandr S. 
Published: April 2023

AbstractTo advance meaningful guidelines in the design of electrocatalytically active catalysts, a knowledge of the nature of active sites is the starting point. However, multiple factors such as material composition, site coordination, electrolyte effects, the support material, surface strain, and others influence catalytic behavior. Therefore, the identification of active sites can be complex. A substantial contributor can be in-situ experiments, which are able to identify active centers in a specific system while the reaction takes place. An example of such a technique is electrochemical scanning tunneling microscopy (EC-STM), which relates locally confined noise features to local electrocatalytic activity. In this work, we spotlight recent achievements of this technique with respect to palladium (Pd) surfaces for the hydrogen reduction reaction, where strain due to hydride formation comes into play in addition to surface coordination. Secondly, we demonstrate the high resolution of the technique on graphite-based surfaces. Here, edge sites are particularly active. Thus, with the EC-STM technique, we take strain effects (like on Pd) or effects of coordination (like on carbon) into account. Therefore, we can determine active sites with great accuracy under reaction conditions.
Reno-protective effects of perioperative dexmedetomidine in kidney transplantation: a systematic review and meta-analysis of randomized controlled trials
Authors: Abuelazm Mohamed T. , Ghanem Ahmed , Johanis Amit , Mahmoud Abdelrahman , Hassan Abdul Rhman , Katamesh Basant E. , Amin Mostafa Atef , Abdelazeem Basel 
Published: April 2023

Abstract
Background and objective
There is currently no FDA-approved medical therapy for delayed graft function (DGF). Dexmedetomidine (DEX) has multiple reno-protective effects preventing ischemic reperfusion injury, DGF, and acute kidney injury. Therefore, we aimed to evaluate the reno-protective effects of perioperative DEX during renal transplantation.

Methods
A systematic review and meta-analysis synthesizing randomized controlled trials (RCTs) from WOS, SCOPUS, EMBASE, PubMed, and CENTRAL until June 8th, 2022. We used the risk ratio (RR) for dichotomous outcomes and the mean difference for continuous outcomes; both presented with the corresponding 95% confidence interval (CI). We registered our protocol in PROSPERO with ID: CRD42022338898.

Results
We included four RCTs with 339 patients. Pooled risk ratio found no difference between DEX and placebo in reducing DGF (RR: 0.58 with 95% CI [0.34, 1.01], p = 0.05) and acute rejection (RR: 0.88 with 95% CI [0.52, 1.49], p = 0.63). However, DEX improved short-term creatinine on day 1 (MD: − 0.76 with 95% CI [− 1.23, − 0.3], p = 0.001) and day 2 (MD: − 0.28 with 95% CI [− 0.5, − 0.07], p = 0.01); and blood urea nitrogen on day 2 (MD: − 10.16 with 95% CI [− 17.21, − 3.10], p = 0.005) and day 3 (MD: − 6.72 with 95% CI [− 12.85, − 0.58], p = 0.03).

Conclusion
Although there is no difference between DEX and placebo regarding reducing DGF and acute rejection after kidney transplantation, there may be some evidence that it has reno-protective benefits because we found statistically significant improvement in the short-term serum creatinine and blood urea nitrogen levels. More trials are required to investigate the long-term reno-protective effects of DEX.
Long term trends of dry and wet deposition of air pollutants at declining forest site of Mt. Oyama in Japan during 1994–2019
Authors: Wang Yize , Okochi Hiroshi , Igawa Manabu 
Published: April 2023

AbstractForest decline, which occurs in mountainous regions in many countries, may result from the effects of acid fog, ozone, or deposition of other pollutants. We observed wet deposition of air pollutants at different altitudes on Mt. Oyama, situated southwest of Tokyo, for 1994 until 2019. During this period, the domestic atmospheric environment was improved in Japan. The average concentration of air pollutants around all the sampling sites on Mt. Oyama decreased by 63.01%, 32.08%, 8.80%, and 39.73% for NH3, HCl, HNO3, and SO2, respectively. The volume weighted mean (VWM) pH values showed an increasing trend for bulk deposition (+0.70% y-1), fog water (+2.58% y-1), and throughfall (+2.60% y-1). Stemflow also increased (cedar, +1.17% y-1; fir, +0.82% y-1), although it included organic acids dissolved from the stem and it primarily had a low VWM pH value. The overall pH value of the fog water increased at the site, although acidic fog was still observed. Comparing fog water between winter and summer, a significant increase in pH occurred in summer, whereas no change occurred in winter. In summer, the sources of pollutants at Mt. Oyama are mainly from mainland Japan, and the frequency of low-pH acidic fog decreased annually. In winter, Mt. Oyama was affected by transboundary pollution, and acid fog occasionally occurred. Improvements in the domestic atmospheric environment and control of transboundary pollution will provide better conditions for mountain ecology that are free from acidic pollutants.
Aluminum Fluoride-18 Labeled Mannosylated Dextran: Radiosynthesis and Initial Preclinical Positron Emission Tomography Studies
Authors: Andriana Putri , Makrypidi Konstantina , Liljenbäck Heidi , Rajander Johan , Saraste Antti , Pirmettis Ioannis , Roivainen Anne , Li Xiang-Guo 
Published: April 2023

Abstract
Purpose
In addition to being expressed on liver sinusoidal endothelial cells, mannose receptors are also found on antigen-presenting cells, including macrophages, which are mainly involved in the inflammation process. Dextran derivatives of various sizes containing cysteine and mannose moieties have previously been labeled with 99mTc and used for single-photon emission computed tomography imaging of sentinel lymph nodes. In this study, we radiolabeled 21.3-kDa D10CM with positron-emitting 18F for initial positron emission tomography (PET) studies in rats.

Procedures
D10CM was conjugated with 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) chelator and radiolabeled with the aluminum fluoride-18 method. The whole-body distribution kinetics and stability of the intravenously administered tracer were studied in healthy male Sprague-Dawley rats by in vivo PET/CT imaging, ex vivo gamma counting, and high-performance liquid chromatography analysis.

Results
Al[18F]F-NOTA-D10CM was obtained with a radiochemical purity of >99% and molar activity of 9.9 GBq/μmol. At 60 minutes after injection, an average of 84% of the intact tracer was found in the blood, indicating excellent in vivo stability. The highest radioactivity concentration was seen in the liver, spleen, and bone marrow, in which mannose receptors are highly expressed under physiological conditions. The uptake specificity was confirmed with in vivo blocking experiments.

Conclusions
Our results imply that Al[18F]F-NOTA-D10CM is a suitable tracer for PET imaging. Further studies in disease models with mannose receptor CD206-positive macrophages are warranted to clarify the tracer’s potential for imaging of inflammation.

Graphical abstract
MRI-based training model for left atrial appendage closure
Authors: Bertsche Dagmar , Pfisterer Mona , Dahme Tillman , Schneider Leonhard-Moritz , Metze Patrick , Vernikouskaya Ina , Rasche Volker 
Published: April 2023

Abstract
Purpose
Percutaneous closure of the left atrial appendage (LAA) reduces the risk of embolic stroke in patients with atrial fibrillation. Thereby, the optimal transseptal puncture (TSP) site differs due to the highly variable anatomical shape of the LAA, which is rarely considered in existing training models. Based on non-contrast-enhanced magnetic resonance imaging (MRI) volumes, we propose a training model for LAA closure with interchangeable and patient-specific LAA enabling LAA-specific identification of the TSP site best suited.

Methods
Based on patient-specific MRI data, silicone models of the LAAs were produced using a 3D-printed cast model. In addition, an MRI-derived 3D-printed base model was set up, including the right and left atrium with predefined passages in the septum, mimicking multiple TSP sites. The various silicone models and a tube mimicking venous access were connected to the base model. Empirical use of the model allowed the demonstration of its usability.

Results
Patient-specific silicone models of the LAA could be generated from all LAA patient MRI datasets. The influence of various combinations regarding TSP sites and LAA shapes could be demonstrated as well as the technical functionality of the occluder system. Via the attached tube mimicking the venous access, the correct handling of the deployment catheter even in case of not optimal puncture site could be practiced.

Conclusion
The proposed contrast-agent and radiation-free MRI-based training model for percutaneous LAA closure enables the pre-interventional assessment of the influence of the TSP site on the access of patient-specific LAA shapes. A straightforward replication of this work is measured by using clinically available imaging protocols and a widespread 3D printer technique to build the model.
An Islamist economic habitus: Islamist-affiliated businesses in Egypt
Authors: Adly Amr 
Published: April 2023

AbstractThe post-2013 crackdown on Islamist-affiliated businesses in Egypt offers a unique glimpse at the Islamists’ economic assets and activities. How could affiliates of the Islamist movement in Egypt accumulate so many assets and become significant market actors since the 1970s despite periodic state hostility and weak property rights protection? I argue that belonging to the Islamist movement endowed affiliated entrepreneurs with an economic habitus. This mode of embeddedness allowed the conversion of organisational, symbolic and social capital from the socio-religious and cultural fields into the market field. However, the Islamist habitus was tension-ridden, hence conflicted, in two principal aspects. It was marked by embeddedness as much as boundedness for the affiliated entrepreneurs. One source of tension was introspective about the actual and perceived (in)compatibility between business activities and the ideological mission of the movement. The other was extrospective related to the power relations with periodically hostile state authorities.
A theoretical essay on socio-technical systems design thinking in the era of digital transformation
Authors: Govers Mark , van Amelsvoort Pierre 
Published: April 2023

AbstractDigital technology is here to stay. Currently, digital technologies are unleashing the fourth industrial revolution. This so-called digital transformation is about the integration of digital technology into all areas of society. Within organisations, work is fundamentally changing which impacts how organisations will operate and deliver value to customers. Furthermore, but often forgotten, it is also about a cultural change that requires organisations to continually challenge their status quo, experiment, and get comfortable with failure.Digital possibilities are emerging which cannot be viewed separately from social effects in organised (eco-)systems and for people in those systems. The challenge is to jointly optimise technical and social aspects for creating both added value in a sustainable manner and improve quality of working life. As we have an ‘organisational choice’, technical possibilities can be aligned with social needs and requirements, and vice versa. This alignment forms the basis of socio-technical systems (STS) thinking, which is necessary for developing sustainable organisational solutions. Sociotechnical theory and practice originally have a focus on optimising social and technical aspects in organisations. Therefore, we choose in this essay for an STS perspective, especially for the STS Design (STS-D) approach which is elaborated by the Lowlands STS school of thought. As digital technologies offer new affordances and constraints for organisational design, we aim, with this essay, to merge STS‑D with digital thinking.We start with a brief sketch of the understanding of current digital technologies. After this, we discuss organisational design in terms of the division of labour and the penetration of digital technology into the nature of work. Then, the STS-D’s core design principles and design sequence, specifically from the Lowlands school of thought, are introduced and adapted for digital thinking. This is followed by a section on design routines for unlocking the potential for designing future, digital-receptive workplaces and organisations. We end the essay with some closing remarks and reflections.
On the Analyses of Medical Images Using Traditional Machine Learning Techniques and Convolutional Neural Networks
Authors: Iqbal Saeed , N. Qureshi Adnan , Li Jianqiang , Mahmood Tariq 
Published: April 2023

AbstractConvolutional neural network (CNN) has shown dissuasive accomplishment on different areas especially Object Detection, Segmentation, Reconstruction (2D and 3D), Information Retrieval, Medical Image Registration, Multi-lingual translation, Local language Processing, Anomaly Detection on video and Speech Recognition. CNN is a special type of Neural Network, which has compelling and effective learning ability to learn features at several steps during augmentation of the data. Recently, different interesting and inspiring ideas of Deep Learning (DL) such as different activation functions, hyperparameter optimization, regularization, momentum and loss functions has improved the performance, operation and execution of CNN Different internal architecture innovation of CNN and different representational style of CNN has significantly improved the performance. This survey focuses on internal taxonomy of deep learning, different models of vonvolutional neural network, especially depth and width of models and in addition CNN components, applications and current challenges of deep learning.