bluuebunny/crossref_metadata_2025_split huggingface dataset:
Far from the truth: Real‐world treatment patterns among newly diagnosed metastatic prostate cancer in the era of treatment intensification
Authors: Yang Xinyan , Tan Yu Guang , Gatsinga Rene , Chen Weiren , Huang Hong Hong , Loong Jeffrey Tuan Kit , Chua Melvin Lee Kiang , Rajasekaran Tanujaa , Kanesvaran Ravindran , Tay Kae Jack , Chen Kenneth , Yuen John Shyi Peng 
Published: July 2023

ObjectivesReal‐world uptake of treatment intensification (TI) with novel hormonal agents (NHA) or chemotherapy as treatment of metastatic prostate cancer remains low outside of trial settings. We aim to report the prescription patterns and treatment outcomes of de novo metastatic hormone‐sensitive prostate cancer (mHSPC) in a tertiary institution.MethodsThis is a retrospective cohort study using real‐world data from a prospectively maintained prostate cancer registry. We selected patients newly diagnosed with mHSPC from January 2016 to December 2020. Clinicopathological parameters were recorded to determine their impact on prescription patterns.ResultsIn total, 585 patients with metastatic prostate cancer were identified. Prescription of NHA increased from 10.5% (2016) to 50.4% (2020), but that of chemotherapy declined. Factors associated with TI were (1) baseline health status: Charlson Comorbidity Index 0–2, ECOG 0–1, age ≤ 65, (2) disease burden: PSA (>400, CHAARTED high volume disease, p = 0.004), development of systemic complications and (3) physician factor: primary physician being uro‐oncologist and medical oncologist versus general urologist. Patients with TI had a longer mean time to castration‐resistant prostate cancer (45.0 vs. 32.5 months, HR 0.567, 95% CI: 0.441–0.730, p < 0.001) and overall survival (55.3 vs. 46.8 months, HR 0.612, 95% CI, 0.447–0.837, p = 0.001).ConclusionThis study demonstrated the trend of treatment prescription of mHSPC and factors contributing to the use of TI. TI improved mean time to CRPC and OS.
First worldwide use of pulsed‐field ablation for ventricular tachycardia ablation via a retrograde approach
Authors: Martin Claire A. , Zaw Myo Thant , Jackson Nicola , Morris Dave , Costanzo Pierluigi 
Published: July 2023

AbstractIntroductionWe present the first worldwide use of pulsed‐field ablation (PFA) for ventricular tachycardia (VT) ablation via a retrograde approach.MethodsThe patient had previously failed conventional ablation of an intramural circuit underneath the aortic valve. The same VT circuit was inducible during the procedure. The Farawave PFA catheter and Faradrive sheath were used to deliver PFA applications.ResultsPost ablation mapping demonstrated scar homogenization. There was no evidence of coronary spasm during PFA applications and no other complications occurred. VT was non‐inducible post ablation and the patient has remained free of arrhythmia at follow‐up.ConclusionPFA for VT via a retrograde approach is feasible and effective.
Pea protein isolate and inulin as plant‐based biomacromolecules for reduction of sugar uptake in osmotic dehydration
Authors: Wang Xiaojuan , Feng Hao 
Published: July 2023

AbstractConcerns have been raised about the potential health risks associated with elevated sugar levels in food products of osmotic dehydration (OD). To address this issue, a new strategy was proposed and validated in this study. Pea protein isolate (PPI) and inulin were introduced into osmotic solutions to reduce sucrose uptake in apple slices. Apple samples were subjected to OD (40%wt sucrose) at 40°C with different concentrations of PPI or inulin. Three parameters, including performance ratio (Pr), dehydration efficiency index (DEI), and sucrose gain rate were used to evaluate the effect of PPI and inulin addition on reducing sucrose uptake. The result showed that sucrose content in apple tissues after OD for 4 h was 51.79 mg/100 mg dry basis when treated by a sucrose solution alone, but was reduced to 43.43 mg/100 mg dry basis and 46.12 mg/100 mg dry basis when 1.5%wt inulin and 3% wt PPI was added, respectively.Practical applicationsThe use of low‐temperature and phase‐change‐free osmotic dehydration methods for the preservation of fruits is advantageous due to low energy consumption, better quality retention, and ease of operation. It has been used to produce intermediate moisture foods or as a pretreatment for other drying methods. However, the most widely used osmotic agents often contain high calories because carbohydrates have become the most popular osmotic agents. This has promoted the exploration of natural methods to reduce sugar uptake while maintaining the drying characteristic of osmotic dehydration. This study was undertaken to investigate the use of two biomacromolecules, that is, pea protein isolate and inulin as a simple yet effective means for achieving sugar reduction. The finding of this work has demonstrated that both methods can significantly reduce sucrose content in dried apple slices, thus confirming the potential for practical applications.
Spontaneous unilateral spatial neglect recovery after brain tumour resection: A multimodal diffusion and rs‐fMRI case report
Authors: Zigiotto Luca , Amorosino Gabriele , Saviola Francesca , Jovicich Jorge , Annicchiarico Luciano , Rozzanigo Umberto , Olivetti Emanuele , Avesani Paolo , Sarubbo Silvio 
Published: July 2023

AbstractPatients with unilateral spatial neglect (USN) are unable to explore or to report stimuli presented in the left personal and extra‐personal space. USN is usually caused by lesion of the right parietal lobe: nowadays, it is also clear the key role of structural connections (the second and the third branch of the right Superior Longitudinal Fasciculus, respectively, SLF II and III) and functional networks (Dorsal and Ventral Attention Network, respectively, DAN and VAN) in USN. In this multimodal case report, we have merged those structural and functional information derived from a patient with a right parietal lobe tumour and USN before surgery. Functional, structural and neuropsychological data were also collected 6 months after surgery, when the USN was spontaneously recovered. Diffusion metrics and Functional Connectivity (FC) of the right SLF and DAN, before and after surgery, were compared with the same data of a patient with a tumour in a similar location, but without USN, and with a control sample. Results indicate an impairment in the right SLF III and a reduction of FC of the right DAN in patients with USN before surgery compared to controls; after surgery, when USN was recovered, patient's diffusion metrics and FC showed no differences compared to the controls. This single case and its multimodal approach reinforce the crucial role of the right SLF III and DAN in the development and recovery of egocentric and allocentric extra‐personal USN, highlighting the need to preserve these structural and functional areas during brain surgery.
Potent pigmentation inhibitory activity of incensole‐enriched frankincense volatile oil‐identification, efficacy and mechanism
Authors: Yan Xiufang , Ma Xiaoyu , Dai Daoxin , Yan Xiaojuan , Han Xingyan , Bao Xijun , Xie Qiufang 
Published: July 2023

AbstractBackgroundFrankincense volatile oil (FVO) has long been considered a side product in pharmaceutical industry since frankincense of large molecular weight is the prime target. However, the volatile oil recycled in the extract process might contain a series of functional actives, serving as promising ingredients in the cosmetic field.MethodsGas chromatography‐mass spectrometer was utilized to determine the species and amount of active ingredients in FVO. Subsequently, zebrafish models were used to evaluate pigmentation inhibition, ROS elimination and neutrophil activation. In vitro DPPH test was also conducted to consolidate the anti‐oxidation efficacy. Based on the test results, network pharmacology was incorporated, where GO and KEGG enrichment analyses were performed to discover the interrelations between active ingredients.ResultsAbout 40 actives molecules were identified, including incensole, acetate incensole, and acetate incensole oxide. The FVO demonstrated great depigmentation activity by suppressing melanin synthesis, as well as providing free radical scavenging and anti‐inflammation effect. In network pharmacology analysis, 192 intersected targets were identified. By enrichment analysis and network construction, a series of whitening signal pathways, and hub genes, containing STAT3，MAPK3，MAPK1 were identified.ConclusionThe current study quantified the components of FVO, evaluated its efficacy in skin depigmentation, and give pioneering insights on the possible mechanism. The results confirmed that the FVO could serve as whitening agent in topical uses.
Noninvasive lipolysis modalities in aesthetic medicine
Authors: Wolska Joanna , Hassan Haidar 
Published: July 2023

AbstractBackgroundAdipose tissue is a vital metabolic organ that takes part in body homeostasis. However, an increase in fat tissue can be detrimental for one's health and lead to undesirable changes in body shape. Noninvasive lipolysis is becoming an increasingly popular method to destroy and remove excess body fat and improve one's satisfaction with their body appearance.AimThe aim of this study was to perform an evidence‐based review of the clinical efficacy and safety of noninvasive lipolysis modalities in fat reduction.Materials and MethodsAn evidence‐based review was performed to evaluate the scientific evidence available on the subject. Three electronic databases (PubMed, Scopus, and Embase) were searched between February and May 2022 for randomized controlled trials and observational studies performed on adult population in the last 20 years investigating the clinical outcomes of noninvasive lipolysis modalities. The selected studies were divided by modality type (cryolipolysis, ultrasound therapy, radiofrequency, and laser therapy), and the data on the efficacy and safety were extracted.ResultsIn total, the search identified 55 papers which met the inclusion criteria. All four energy‐based modalities, including cryolipolysis, ultrasound therapy, radiofrequency, and laser therapy, were shown to be clinically effective in terms of both objective body measurements, such as fat layer thickness or circumference reduction, and subjective patient satisfaction. Furthermore, the abovementioned methods were proven to have a low side effect profile.ConclusionIn conclusion, although evidence supports safety and efficacy, further well‐designed trials are needed to strengthen confidence in long‐term effectiveness and safety of noninvasive lipolysis.
Beyond the Feeling Individual: Insights from Sociology on Emotions and Embeddedness
Authors: Zhang Rongrong , Voronov Maxim , Toubiana Madeline , Vince Russ , Hudson Bryant Ashley 
Published: July 2023

AbstractOrganizational scholars have treated emotions mostly as an individual‐level phenomenon, with limited theorisation of emotions as an important component in social embeddedness. In this review essay, we argue for the need for a toolkit to study emotions as an inherently social phenomenon. To do so, we apply insights from sociology that have been under‐utilized in management and organization research. We focus on three sociological concepts: collective emotions and social bonds, emotional energy and moral batteries, and emotional capital. We then develop an integrative model of emotional embeddedness to emphasize that emotions are socially constructed and socially authorized. We end the paper by setting out a research agenda for more research in management and organization that is informed by these three concepts.
Confronting the grand challenge of environmental sustainability within supply chains: How can organizational strategic agility drive environmental innovation?
Authors: Bouguerra Abderaouf , Hughes Mathew , Rodgers Peter , Stokes Peter , Tatoglu Ekrem 
Published: July 2023

AbstractSupply chains are interconnected, globally distributed, and complex systems that significantly impact the environment and human civilization. Achieving environmental sustainability in supply chains is a grand challenge that requires collaboration and innovation among multiple stakeholders. In this study, we combine the natural‐resource‐based view and the stakeholder‐resource‐based view (SRBV) to examine how organizational strategic agility can foster collaborative environmental innovation and enhance environmental sustainability in supply chains. We use data from 758 managers from 185 firms in Turkey, an emerging economy context. We find that organizational strategic agility, enabled by organic organizational structures and regional innovation initiatives, leads to more collaborative environmental innovation with supply partners and higher environmental sustainability performance. Our study contributes to the literature on grand challenges, organizational strategic agility, and innovation management by showing how for‐profit firms can leverage their strategic agility to address the grand challenge of environmental sustainability in supply chains. We also find two interventions to promote this form of environmental innovation: developing organizational strategic agility and organic structures within firms and involvement in regional innovation initiatives to stimulate collaborative innovation for environmental sustainability among supply partners.
We are all in this together: Rurality, Social cohesion, and COVID‐19 prevention behaviors
Authors: Sood Radhika , Entenman Juliette , Kitt‐Lewis Erin , Lennon Robert P. , Pinto Casey N. , Moss Jennifer L. 
Published: July 2023

AbstractBackgroundSocial cohesion refers to an individual's sense of belonging to their community and correlates with health outcomes. Rural communities tend to have higher social cohesion than urban communities. Social cohesion is relatively understudied as a factor impacting COVID‐19 prevention behaviors. This study explores the associations between social cohesion, rurality, and COVID‐19 prevention behaviors.MethodsParticipants completed a questionnaire assessing rurality; social cohesion (subscales of (1) attraction to neighborhood, (2) acts of neighboring, and (3) sense of community); COVID‐19 behaviors; and demographics. Chi‐square tests were used to characterize participant demographics and COVID‐19 behaviors. Bivariate and multivariable logistic regression models were used to analyze the relationship between COVID‐19 outcomes and rurality, social cohesion, and demographics.ResultsMost participants (n = 2,926) were non‐Hispanic White (78.2%) and married (60.4%); 36.9% were rural. Rural participants were less likely than urban participants to practice social distancing (78.7% vs 90.6%, P<.001) or stay home when sick (87.7% vs 93.5%, P<.001). Social distancing was more common among participants with higher “attraction to neighborhood” scores (adjusted odds ratio [aOR] = 2.09; 95% confidence interval [CI] = 1.26‐3.47) but was less common among participants with higher “acts of neighboring” scores (aOR = 0.59; 95% CI = 0.40‐0.88). Staying home when sick was also more common among participants with higher scores on “attraction to neighborhood” (aOR = 2.12; 95% CI = 1.15‐3.91), and less common among participants with higher scores on “acts of neighboring” (aOR = 0.53; 95% CI = 0.33‐0.86).ConclusionsEfforts to maximize COVID‐19 behavioral prevention, particularly among rural communities, should emphasize the importance of protecting the health of one's neighbors and how to support one's neighbors without face‐to‐face interactions.
Social positioning theory and quantum mechanics
Authors: Lawson Tony 
Published: July 2023

AbstractSocial positioning theory, or an account of the human individual that it grounds, qualifies as a quantum social theory. This is an assessment that I explain and defend in the paper. It is of interest in that, in a world where increasing numbers are seeking to construct quantum social theories, it serves to help demonstrate that this goal can be achieved without giving up on meeting criteria like explanatory intelligibility or power or discarding real‐world notions like human (and other) entities. As it turns out, a central feature of the account defended and a core element of the ‘standard’ interpretation of quantum mechanics are found to stand in an interesting, unanticipated and suggestive relation to each other.
Contrasting host use and feeding behavior by sympatric mesograzers
Authors: Paula Caio A. , Borges Dalila J. , Andrade Aynara R. , Leite Fosca P. P. , Costa Tânia M. , Machado Glauco B. O. 
Published: July 2023

AbstractMarine mesograzers use macroalgae as food and habitat and may have strong top‐down effects on plants and macroalgae. Sympatric mesograzer species often differ regarding host use and feeding behavior, which may lead to distinct impacts by these consumers on primary producers. The amphipods Hyale niger and Ampithoe marcuzzii are mesograzers abundant that co‐occur in Brazilian waters and, although they use several macroalgae as habitat, it is unknown how much the food value of these hosts explains the host use pattern by the two mesograzers. Herein, we investigated the abundance and feeding behavior of the sympatric amphipods H. niger and A. marcuzzii. For that, their abundance on the macroalgal hosts Sargassum filipendula, Padina gymnospora, and Dichotomaria marginata was evaluated seasonally in a rocky shore at Fortaleza Beach, state of São Paulo, Brazil. Also, multiple‐choice and no‐choice feeding experiments were carried out at laboratory to evaluate the feeding behavior of these mesograzers. The abundance of H. niger was similar among the three macroalgal hosts (except during winter), while A. marcuzzii was more abundant on Dichotomaria and Padina than Sargassum in all seasons. Moreover, H. niger consumed more Padina than Dichotomaria and Sargassum in both feeding experiments. In turn, A. marcuzzii preferred to feed on Padina when it had a choice and consumed the three macroalgal hosts at similar levels in the no‐choice feeding experiment. Overall, H. niger and A. marcuzzii differ from each other regarding their feeding behavior and host use pattern. In particular, the food value of macroalgae seems to partially explain the host use by A. marcuzzi, but not by H. niger. The differences between H. niger and A. marcuzzii may result in varying impacts on primary producers.
Past antihypertensive medication use is associated with lower levels of small vessel disease and lower Aβ plaque stage in the brains of older individuals
Authors: Affleck Andrew J. , Sachdev Perminder S. , Halliday Glenda M. 
Published: July 2023

AbstractAimsThis study assesses the association of antihypertensive medication use on the severities of neuropathological cerebrovascular disease (CVD excluding lobar infarction) in older individuals.MethodsClinical and neuropathological data were retrieved for 149 autopsy cases >75 years old with or without CVD or Alzheimer's disease and no other neuropathological diagnoses. Clinical data included hypertension status, hypertension diagnosis, antihypertensive medication use, antihypertensive medication dose (where available) and clinical dementia rating (CDR). Neuropathological CVD severity was evaluated for differences with anti‐hypertensive medication usage.ResultsAntihypertensive medication use was associated with less severe white matter small vessel disease (SVD, mainly perivascular dilatation and rarefaction), with a 5.6–14.4 times greater likelihood of less severe SVD if medicated. No significant relationship was detected between infarction (presence, type, number and size), lacunes or cerebral amyloid angiopathy and antihypertensive medication use. Only increased white matter rarefaction/oedema and not perivascular dilation was associated with Alzheimer's pathology, with a 4.3 times greater likelihood of reduced Aβ progression through the brain if white matter rarefaction severity was none or mild. Antihypertensive medication use was associated with reduced Aβ progression but only in those with moderate to severe white matter SVD.ConclusionsThis histopathological study provides further evidence that antihypertensive medication use in older individuals is associated with white matter SVD and not with other CVD pathologies. This is mainly due to a reduction in white matter perivascular dilation and rarefaction/oedema. Even in those with moderate to severe white matter SVD, antihypertensive medication use reduced rarefaction and Aβ propagation through the brain.
Epicardial connections and bi‐atrial tachycardias: From anatomy to clinical practice
Authors: Lai Yiwei , Ge Weili , Sang Caihua , Macle Laurent , Tang Ribo , Long Deyong , Dong Jianzeng , Ma Changsheng 
Published: July 2023

AbstractBi‐atrial tachycardia (BiAT) is not rare after extensive atrial ablation or cardiac surgery. The complexity of bi‐atrial reentrant circuits poses a great challenge for clinical practice. With recent advances in mapping technologies, we are now able to characterize atrial activation in detail. However, given the involvement of both atria and multiple epicardial conductions, endocardial mapping for BiATs is not easy to understand. Knowledge of the atrial myocardial architecture is the foundation for the clinical management of BiATs; as it is required to understand the possible mechanism of the tachycardia and identify the optimal target of ablation. In this review we summarize current knowledge about the anatomy of interatrial connections as well as other epicardial fibers and discuss the interpretation of electrophysiological findings and ablation strategies for BiATs.
Comparative pangenome analyses provide insights into the evolution of Brassica rapa resistance gene analogues (RGAs)
Authors: Amas Junrey C. , Bayer Philipp E. , Hong Tan Wei , Tirnaz Soodeh , Thomas William J. W. , Edwards David , Batley Jacqueline 
Published: July 2023

SummaryBrassica rapa is grown worldwide as economically important vegetable and oilseed crop. However, its production is challenged by yield‐limiting pathogens. The sustainable control of these pathogens mainly relies on the deployment of genetic resistance primarily driven by resistance gene analogues (RGAs). While several studies have identified RGAs in B. rapa, these were mainly based on a single genome reference and do not represent the full range of RGA diversity in B. rapa. In this study, we utilized the B. rapa pangenome, constructed from 71 lines encompassing 12 morphotypes, to describe a comprehensive repertoire of RGAs in B. rapa. We show that 309 RGAs were affected by presence‐absence variation (PAV) and 223 RGAs were missing from the reference genome. The transmembrane leucine‐rich repeat (TM‐LRR) RGA class had more core gene types than variable genes, while the opposite was observed for nucleotide‐binding site leucine‐rich repeats (NLRs). Comparative analysis with the B. napus pangenome revealed significant RGA conservation (93%) between the two species. We identified 138 candidate RGAs located within known B. rapa disease resistance QTL, of which the majority were under negative selection. Using blackleg gene homologues, we demonstrated how these genes in B. napus were derived from B. rapa. This further clarifies the genetic relationship of these loci, which may be useful in narrowing‐down candidate blackleg resistance genes. This study provides a novel genomic resource towards the identification of candidate genes for breeding disease resistance in B. rapa and its relatives.