bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer heterocyclic hybrids: design, synthesis, molecular docking and evaluation of new thiazolidinone-pyrazoles
Authors: Shrivastava Neelima , Khan Shah Alam , Alam Mohammad Mumtaz , Akhtar Mymoona , Srivastava Apeksha , Husain Asif 
Published: January 2023

Abstract
In order to obtain potential anticancer agents, hybrid compounds have been synthesized by coupling thiazolidinone and pyrazole scaffolds. Among the synthesized compounds, 2-(1,3-diphenyl-1H-pyrazol-4-yl)-3-phenyl thiazolidin-4-one (4a) was found to be the most potent based on a docking (−9.307) and binding scores (−66.46), along with good ADME parameters. In vitro anticancer activity of compound 4a shows a maximum inhibition against lung cancer (NCI-H23) cell lines with a moderate inhibition rate of 31.01%. Molecular docking studies revealed that these hybrid compounds bind well to the active site of peroxisome proliferator-activated receptors-gamma (PPAR-gamma). Doxorubicin was used as a positive control. It can be concluded that 4a having pyrazole-thiazolidinone ring systems has the potential to be developed as an anticancer agent.
Modified oligoether-diamine synthesis for the preparation of crystallizable polymers based on epoxyurethane oligomers
Authors: Slobodinyuk Alexey , Elchisheva Nadezhda , Strelnikov Vladimir , Chernova Galina , Slobodinyuk Daria 
Published: January 2023

Abstract
A modified synthetic method for amino-terminated oligo tetramethylene oxides is presented. Diamines were synthesized via a three-step route from oligo tetramethylene oxide diol with an average molecular weight of 2000. The final step – oligoether-diphthalimide hydrazinolysis – has been improved. The yield of the target product has been shown to be more than 1.5 times higher when the molar ratio of the reacting components was changed. The oligoether-diamine and the reaction intermediates have been identified by 1H and 13C NMR spectroscopy. It has been demonstrated that the synthesized amine can be used as a curing agent for epoxy urethane oligomers. It is shown that the glass transition temperature of the cured elastomers is lower than −70 °C. These elastomers can be recommended for the use in the conditions of the Arctic and the Far North or Far South of the globe.
Canagliflozin Regulates Ferroptosis, Potentially via Activating AMPK/PGC-1α/Nrf2 Signaling in HFpEF Rats
Authors: Ma Sai , He Lili , Zuo Qingjuan , Zhang Guorui , Guo Yifang 
Published: January 2023

Aims:Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been found to ameliorate major adverse cardiovascular events in patients with heart failure with preserved ejection fraction (HFpEF), but the exact mechanism is unknown. Ferroptosis is a form of programmed necrosis. Herein, we verified that canagliflozin (CANA) ameliorates heart function in HFpEF rats, partly by regulating ferroptosis, which may be activated by AMPK/PGC-1α/Nrf2 signaling.Methods:An HFpEF model was established and subjected to CANA treatment. Blood pressure was monitored, and echocardiography was performed at the 12thweek. Pathological examination was performed, and expression of ferroptosis-associated proteins and AMPK/PGC-1α/Nrf2 signaling related proteins was detected.Results:CANA had an antihypertensive effect and increased E/A ratios in HFpEF rats. Myocardial pathology was ameliorated, on the basis of decreased cross-sectional area and intercellular fibrosis. Acyl-CoA synthetase long-chain family member 4 (ACSL4) expression increased, whereas ferritin heavy chain 1 (FTH1) expression decreased in HFpEF rats, which showed iron overload. CANA reversed changes in ACSL4 and FTH1, and decreased iron accumulation, but did not alter glutathione peroxidase 4 (GPX4) expression. The expression of AMPK/PGC-1α/Nrf2 signaling related proteins and heme oxygenase 1 (HO-1) in the HFpEF group decreased but was reverted after CANA treatment.Conclusions:CANA regulates ferroptosis, potentially via activating AMPK/PGC-1α/Nrf2 signaling in HFpEF rats.
Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression
Authors: Lima-Filho Ricardo , Fortuna Juliana S. , Cozachenco Danielle , Isaac Alinny R. , Lyra e Silva Natalia , Saldanha Alice , Santos Luis E. , Ferreira Sergio T. , Lourenco Mychael V. , De Felice Fernanda G. 
Published: January 2023

AbstractMajor depressive disorder (MDD) is a major cause of disability in adults. MDD is both a comorbidity and a risk factor for Alzheimer’s disease (AD), and regular physical exercise has been associated with reduced incidence and severity of MDD and AD. Irisin is an exercise-induced myokine derived from proteolytic processing of fibronectin type III domain-containing protein 5 (FNDC5). FNDC5/irisin is reduced in the brains of AD patients and mouse models. However, whether brain FNDC5/irisin expression is altered in depression remains elusive. Here, we investigate changes infndc5expression in postmortem brain tissue from MDD individuals and mouse models of depression. We found decreasedfndc5expression in the MDD prefrontal cortex, both with and without psychotic traits. We further demonstrate that the induction of depressive-like behavior in male mice by lipopolysaccharide decreasedfndc5expression in the frontal cortex, but not in the hippocampus. Conversely, chronic corticosterone administration increasedfndc5expression in the frontal cortex, but not in the hippocampus. Social isolation in mice did not result in alteredfndc5expression in either frontal cortex or hippocampus. Finally, fluoxetine, but not other antidepressants, increasedfndc5gene expression in the mouse frontal cortex. Results indicate a region-specific modulation offndc5in depressive-like behavior and by antidepressant in mice. Our finding of decreased prefrontal cortexfndc5expression in MDD individuals differs from results in mice, highlighting the importance of carefully interpreting observations in mice. The reduction infndc5mRNA suggests that decreased central FNDC5/irisin could comprise a shared pathologic mechanism between MDD and AD.
Partidos políticos y competición electoral. Cuando la Ciencia Política confronta el Derecho
Authors: Fernández Luiña Eduardo , Fernández Luiña Eduardo , Trujillo Álvarez Pedro 
Published: January 2023

La definición de partido político ha sido, desde la reconversión de la ciencia política en la segunda mitad del siglo XX, uno de los grandes temas de la disciplina. Dicha conceptualización ha contribuido al desarrollo de varias teorías dedicadas a interpretar, explicar el funcionamiento y clasificar los distintos sistemas de partidos. El esfuerzo intelectual de definición ha chocado con otro tipo de conceptualizaciones provenientes de disciplinas afines como el Derecho. Los motivos que han generado esta disociación entre definiciones politológicas y jurídicas podrían ser varios. Sin embargo, las consecuencias para el sistema político son muy claras. El trabajo presenta un estudio de caso sobre el sistema político guatemalteco y los problemas asociados a la conceptualización de la figura del partido político. Se observa que la definición jurídica eleva los costos de participación dificultando el acceso de los ciudadanos a las instituciones públicas. Además de presentar los elementos que las organizaciones guatemaltecas deben poseer para convertirse en partidos, el texto evidencia como dichos requisitos no sólo alzan los citados costes de participación, sino que reducen la competencia limitando la acción de actores alternativos, los denominados comités cívicos, que podrían pugnar presentando candidaturas distritales de naturaleza nacional y con ello contribuir a la dinamización de la estructura de competición electoral existente en el país. La conclusión a la que llega nuestra investigación es: el sistema político guatemalteco presenta una clara disonancia entre la definición politológica de partido político y la definición jurídica que, inevitablemente, eleva los costos de participación y con ello limita la competencia a nivel general dentro del sistema.
Early Identification of Severe Sepsis in Pediatric Patients Using an Electronic Alert System
Authors: Oddiri Uchechi , Propper Grace , Brill Patricia , Reid Brienna , Giarraputo Dominic , Milana Carolyn 
Published: January 2023

INTRODUCTION
Prompt sepsis recognition and the initiation of standardized treatment bundles lead to improved outcomes. We developed automated severe sepsis alerts through the electronic medical record and paging system to aid clinicians in rapidly identifying pediatric patients with severe sepsis in our emergency department and inpatient units. Our Specific, Measurable, Applicable, Realistic, Timely aim was to improve 1-hour severe sepsis treatment bundle compliance to 60% with these electronic interruptive alerts.

METHODS
We developed the alert’s criteria based on the 2005 International Pediatric Sepsis Consensus definitions. We performed 2 interventions: requiring the bedside nurse to answer the already implemented nurse-targeted (NT) severe sepsis alert, and the implementation of the physician-targeted (PT) severe sepsis alert. When systemic inflammatory response syndrome criteria were met, the NT alert triggered, and when organ dysfunction was also identified, an interruptive PT alert triggered, and the respective clinician was paged to evaluate the patient. Our primary outcome measure was bundle compliance; our secondary measure was PT alert response compliance.

RESULTS
Baseline severe sepsis treatment bundle compliance was 37%. After requiring nursing response to the NT alert in 2016 and implementing the PT alert in 2018, our bundle compliance rose to 69% in 2020, demonstrating statistically significant difference (P = .006). PT alert response compliance rose from 67% in 2018 to 91% in 2020.

CONCLUSIONS
An interruptive severe sepsis screening alert sent directly to clinicians is a valuable tool to ensure prompt severe sepsis recognition and treatment. This biphasic alert system facilitated multidisciplinary collaboration in early sepsis diagnosis and management.
Regionalitätskonzepte – Ungarische Literaturgeschichtsschreibung nach 1945 im Kontext der rumänischen Literaturgeschichte
Authors: Vincze Ferenc 
Published: January 2023

AbstractIn the discourse of 20th and 21st century Hungarian literary history writing the aspect of regionality is recurrently present, primarily in relation to minority/ethnic Hungarian literature. The positions and relations of these literatures can be inferred not only from the perspective of their naming and designation, but also from the way they are discussed or even represented as books. The study attempts to show the regionality formations in the history of Hungarian literature, which in mutual reflection, overlapping and displacement, have tried to gain a dominant position in the discourse on Hungarian literature. As a point of comparison, the essay also includes the regionality phenomena of Romanian literature in the field of interpretation.
Zebranie Synodu Biskupów według Regulaminu z 2006 roku
Authors: Rozktur Tomasz 
Published: January 2023

Dopo aver terminato il Concilio Vaticano II, il Sinodo dei Vescovi rimane un’istituzione che, avendo le radici nel Concilio, forma l’immagine della Chiesa post-conciliare. Perciò uno dei più significativi contributi del Concilio Vaticano II alla struttura organizzativa e al sistema amministrativo della Chiesa è indubbiamente proprio il Sinodo dei Vescovi, ciò viene confermato dal periodo post- conciliare insieme alle riunioni di questa istituzione che sono state già ventitre. Contemporaneamente il Sinodo dei Vescovi ha svolto e svolge ancora un importante ruolo anche durante i pontificati dei papi post-conciliari, in particolare negli anni del lungo ponificato di Giovanni Paolo II (1978–2005), anche il pontificato attuale dimostra che il papa Benedetto XVI dà molta importanza a questa istituzione convocando regolarmente il Sinodo dei Vescovi. Nell’articolo viene presentato il nuovo regolamento del Sinodo dei Vescovi (Ordo Synodi Episcoporum) approvato da Benedetto XVI nel 2006. Gli articoli del Regolamento del 2006 ci dimostrano che abbiamo a che fare con un’istituzione nella Chiesa postconciliare, dal punto do vista giuridico, organizzata molto bene.
Ochrona tajemnicy spowiedzi. Zakaz wyjawiania okoliczności uciążliwych dla penitenta
Authors: Rakoczy Tomasz 
Published: January 2023

The subject of the article is a norm of can. 984 § 1 that is expressed in statement: “A confessor is completely prohibited from using the knowledge acquired from confession to the detriment of the penitent even when any danger of revelation is excluded”. The basic problem of the article is the correct understanding of the sacramental seal. It embraces not only direct or indirect violation of the seal, but also refers to every circumstance that could be inconvenient for the penitent. The article shows arguments that might cause the departing from the ban. They are as follows: the care of a better celebration of the sacrament of penance, consultation with another confessor in case of the necessity, revelation of the sin for granting faculty and the dialogue with penitent about confession on penitent’s wish. The Roman congregations and blessed Pope John Paul II used to warn confessors against the unwise revelation of the knowledge acquired from confession. The problem is still serious and requires permanent care of the bishops, including the use of the canonical penalties.
Znaczenie i rola wychowania religijnego w jednoczeniu wspólnoty rodzinnej
Authors: Jóżwik Michał 
Published: January 2023

In Christian culture religious education is understood as supporting a person in their development and growth in religious maturity that is presented by Jesus the role model.Christian faith motivates a man to aim at integral and broad development that is achieved through self-discovery, self-evaluation and self-education.Family life in faith unites the whole family even more. Faith brings answers to the most important questions that dwell in a human being in his most significant matters related to the aim of life and its meaning. Faith sustains the parental authority weakening in he eyes of a child, ordering respect towards parents but also towards a child.Depriving one of their family, of the supernatural values and rejecting Christ leads to the death of faith, to cutting it off the proper source from which faith dwells its life and spiritual power.The aim of this article is to attempt showing the role of religious upbringing in unifying a family according to the Christian concept of self-education and the teachings of John Paul II.
Przeszkody do przyjęcia i wykonywania święceń w Kodeksie Prawa Kanonicznego z 1983 roku
Authors: Zaborowski Marek 
Published: January 2023

Der obige Artikel schildert die Problematik der Irregularitäten und Hindernisse zum Empfang und zur Ausübung der Weihen. Dieses Problem wird durch den gültigen Codex des kanonischen Rechts in Kanonen 1040–1046 geregelt. Diese Grundsätze haben den Schutz und Beachtung der Heiligkeit und Würde des Weihesakraments zum Ziel. Die Kirche war seit den Zeiten der Apostel stets darum bemüht, dass sich die Priester durch solche Eigenschaften auszeichen, die ihrer großen Würde entsprechen würden. Auch heutzutagen ist die Sorge um eine entsprechende Geistesbildung der angehenden Priester eine der wichtigsten Fragen der Kirche.
Features of Regulatory Legal Regulation of Administrative and Legal Protection of the Sovereignty of the Russian Federation from Unfriendly Actions of Foreign States
Authors: Troshev D. B. 
Published: January 2023

The publication examines the specifics of the regulatory legal regulation of public administration activities under the unprecedented pressure of a number of foreign states on the Russian Federation, affecting to one degree or another, in fact, most areas of public administration. The author comes to the conclusion about the direct relationship of unfriendly actions of foreign states with threats to the sovereignty of the Russian Federation and the need for legal science to develop a universal legal mechanism for its administrative and legal protection in this regard.The article examines the legislative acts that lay the legal basis for Russia’s response to unfriendly actions (including through the use of retaliatory measures) and the provisions of which are developed in subordinate law-making at various levels.Based on the analysis of legislation and scientific doctrine, the peculiarities of public administration in the conditions of pronounced unfriendly actions of individual states are determined, and its main elements that are subject to study and improvement are also identified.
Public Administration and Regulatory Space in the Field of Artificial Intelligence
Authors: Ponkin I. V. 
Published: January 2023

The article is devoted to assessing the completeness and quality of legal regulation in the field of artificial intelligence and legal support for the use of artificial intelligence in public administration. The author shows the state and development of artificial intelligence regulation in Russia.The author shows that the segments of conceptual and doctrinal and strategic planning acts and the segment of standardizing documents in Russia have been created and filled to a certain extent in the country (at least purely formally), but there are no acts of legal regulation today, neither in a full-fledged modality, nor as some starting point.The article reveals some key problems in the field of regulating the development, testing, implementation and use of artificial intelligence. The author raises the issue of separating the real developments of artificial intelligence technologies that are promising for use in public administration or are already being used or tested in this area, and outright deception in this area. The article proposes a mechanism for searching for appropriate solutions. The author proposes priority measures for completing the regulatory space in the field of artificial intelligence.
Frequency-Dependent Velocity Changes of the 2018 Ms 4.5 Shimian Earthquake Revealed by Repeating Earthquakes
Authors: Zhou Cong , Shi Kexu , Zhang Pei , Zeng Xiangzhi , Zhang Meng 
Published: January 2023

Abstract
The wide application of seismic dense arrays has facilitated the monitoring of the coseismic velocity disturbance of small and medium earthquakes. In this study, a repeating earthquake cluster near the 2018 Ms 4.5 Shimian earthquake was relocated based on 10 groups of repeating earthquakes that occurred from 2013 to 2019, which were recorded by the Xichang seismic array. A repeating pair was obtained by estimating the overlap of the rupture region. Coda-wave interferometry was carried out in different frequency bands using the moving window cross spectrum and wavelet-domain trace stretching (WTS) methods. Our results show that velocity change at each frequency point can be obtained with the WTS method, and thus its frequency resolution is higher. In addition, the velocity changes of coda waves strongly depend on the frequency in the Shimian area, varying from +0.10% in the high-frequency band (5–10 Hz) to −0.23% in the low-frequency band (0.5–2 Hz). In particular, XC04, which is the station that closest to the epicenter, shows the largest velocity change in the low-frequency band, but the velocity change gradually decreases as the distance from the epicenter increases. It has been suggested that the low-frequency components of the coda waves of repeating earthquakes are more sensitive to medium variation. Combined with the earthquake relocation in the Shimian area, it was found that the normalized depth sensitivity calculated based on scattered waves can retain &gt;10% sensitivity in the source area of the Shimian earthquake. Furthermore, the negative velocity changes calculated from low-frequency coda waves are likely attributed to the Shimian earthquake. It is recommended that the average interstation spacing of seismic dense array should be &lt;30 km to facilitate the monitoring of the coseismic changes of small and medium earthquakes.
Detailed Imaging of a Seismogenic Fault That Potentially Induced the Two 2019 Weiyuan Moderate Earthquakes in the Sichuan Basin, China
Authors: Liu Guanshen , Lu Renqi , He Dengfa , Tao Wei , Su Peng , Zhang Weikang , Zhang Jinyu , Xu Fang , Sun Xiao , Wang Wei 
Published: January 2023

Abstract
Induced earthquakes are becoming a significant issue. Several destructive induced earthquakes (Ms ≥5.0) have occurred in shale gas fields located at the southwestern Sichuan basin, China, in the recent years. Specifically, two moderate earthquakes with magnitudes of Ms 5.4 (occurred on 8 September 2019) and 5.2 (occurred on 18 December 2019) exceeded the largest earthquake ever recorded in the Weiyuan. It remains unclear which seismogenic faults were responsible for the two moderate events due to insufficient knowledge of the subsurface structure and contradictory hypocenter depths obtained from different seismological methods. In this study, mainshock locations, focal mechanisms, and precise relocations of microseismicity were used to map the 3D geometry of the seismogenic fault. The result shows that the two moderate earthquakes occurred on the same fault. High-resolution seismic reflection profiles indicate several preexisting faults at various depths and a potential seismogenic fault. No large-scale faults are identified in the sedimentary cover above the Cambrian at the shallow centroid depth of these earthquakes. However, the seismic reflectors show phase discontinuous feature, indicating the existence of preexisting faults in the basement. A preexisting fault in the basement is consistent with a seismogenic fault that may have induced the two moderate earthquakes. Our study suggests that poroelastic stress propagation is likely responsible for the basement fault reactivation. The rupture on a stressed basement fault was triggered and produced two moderate earthquakes in a short period during hydraulic fracturing. The previous strategy of avoiding direct injection of fluids into preexisting faults to reduce seismic risk in operation region is not enough to avoid the possibility of the coupled poroelastic stress triggering deep fault rupture. We need to reevaluate the potential seismic risk of shale gas development in Weiyuan, the southern Sichuan basin shale gas field considering the preexisting faults in sedimentary and in basement and the effect of the fully coupled poroelastic stress field.
The effect of kangaroo mother care on stabilization of vital signs heart rate, respiratory rate and arterial saturation in low-birth-weight preterm babies
Authors: D. H. Deepak 
Published: January 2023

Background: Kangaroo mother care (KMC) have positive effects on the preterm infant's health status in the form of stabilization of vital parameters. Therefore, this study was conducted to evaluate the effect of KMC on stabilization of vital signs in low-birth-weight premature babies.
Methods: This is a quasi-experimental study. One hundred and seventy newborns who were admitted to in neonatal intensive care unit of Karnataka institute of medical sciences Hubli, India were selected by convenience sampling. They were randomly divided into experimental group, n=85 and control group, n=85. In the experimental group, newborns were taken daily KMC for four hours during 7 days. In the control group, routine care was performed. The data gathering tool was questionnaire of infants and mother characteristics, checklists of vital signs using SPSS 22 version software. Chi-square test was used as test of significance for qualitative data. Continuous data was represented as mean and SD. P<0.05 was considered as statistically significant.
Results: Before intervention, there was no significant difference between the vital signs of the infants in experimental and control groups. However, after intervention, there was a significant difference between the two groups in terms of vital parameters (p<0.001).
Conclusions: The findings of this study indicate the effect of KMC on stabilization of vital signs, it is recommended that KMC is taken as one of the routine cares of premature low birth weight babies.