bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catholic and Tamil Divine Mothers
Authors: Granziera Patrizia 
Published: September 2023

Abstract
The cult of the Virgin Mary in southern India and especially in Tamil Nadu is very popular, and she certainly incarnates the emblematic figure of contemporary Indian Catholicism. After the arrival of the Portuguese in India, the task of evangelization was in the hands of the missionary orders who worked under Portuguese rule. In the seventeenth century, the centre of interest in Christian missions in India moved southwards to the Tamil country. It was the Jesuits who ruled and administered over the area for the next century or so. They contributed to the assimilation of the Virgin Mary into the Tamil villagers’ pantheon, trying to translate the Catholic conception of the divine into Tamil and locating the Catholic faith at “home” in the Tamil world. This study will try to explain how missionaries succeeded in spreading the cult of a new Catholic female deity among devotees of the grama-devatas.
Firearm Violence Involving Adults 65 and Older During the Novel Coronavirus Disease Pandemic
Authors: Tan Heidi , Shipley Jonathan , Park Flora S. , Donnelly Megan R. , Kong Allen P. , Barrios Cristobal , Grigorian Areg , Nahmias Jeffry 
Published: September 2023

Background Rates of firearm violence (FV) surged during the COVID-19 pandemic. However, there is a paucity of data regarding older adults (OAs) (≥65 years old). This study aimed to evaluate patterns of FV against OAs before and after the COVID-19 pandemic, hypothesizing decreased firearm incidents, injuries, and deaths for OAs due to restricted social movement. Methods Retrospective (2016-2021) data for OAs were obtained from the Gun Violence Archive. The rate of FV was weighted per 10,000 OAs using annual population data from the United States Census Bureau. Mann-Whitney U tests were performed to compare annual firearm incidence rates, number of OAs killed, and number of OAs injured from 2016-2020 to 2021. Results From 944 OA-involved shootings, 842 died in 2021. The median total firearm incidents per month per 10,000 OAs decreased in 2021 vs 2016 (.65 vs .38, P < .001), 2017 (.63 vs .38, P < .001), 2018 (.61 vs .38, P < .001), 2019 (.39 vs .38, P = .003), and 2020 (.43 vs .38, P = .012). However, there was an increased median number of OAs killed in 2021 vs 2020 (.38 vs .38, P = .009), but no difference from 2016-2019 vs 2021 (all P > .05). The median number of firearm injuries decreased from 2017 to 2021 (.21 vs .19, P = .001) and 2020 to 2021 (.19 vs .19 P < .001). Discussion Firearm incidents involving OAs decreased in 2021 compared to pre-pandemic years; however, there was a slight increase in deaths compared to 2020. This may reflect increased social isolation; however, future research is needed to understand why this occurred.
Successful aortic arch cannulation and perfusion of a heart donated after circulatory death: A case report
Authors: Vervoorn Mats T. , van Kaam Paul , Mokhles Mostafa M. , van der Kaaij Niels P. , Gianoli Monica 
Published: September 2023

Introduction We describe successful aortic arch cannulation and perfusion of a heart donated after circulatory death using the Transmedics Organ Care System™. Case report A 47-year old man developed advanced heart failure symptoms after prior mustard operation for transposition of the great arteries. He matched a DCD-donor and required an elongated aorta for implantation due to his altered anatomy. The donor heart was retrieved and successfully perfused via aortic arch cannulation for 4.5 h with satisfactory perfusion parameters. Disussion Although Transmedics advises against aortic arch cannulation due to concerns regarding malperfusion, satisfactory and safe perfusion can be achieved by careful positioning of the heart. Awareness and attention to the occurrence of malperfusion is mandatory, especially during transport, to achieve satisfactory outcome. Conclusion Aortic arch cannulation is feasible without compromising quality of perfusion. This is relevant for patient that require an elongated aorta after surgically corrected congenital heart disease.
On compressive properties of 3D printed polyvinylidene fluoride composite for implant applications
Authors: Husain Minhaz , Singh Rupinder , Pabla Bahadur Singh 
Published: September 2023

Numerous studies have reported the use of 3D-printed biocompatible intramedullary (IM) pins of various metals, alloys, and composite materials for a variety of orthopedic requirements in canines. One of the limitations of these IM pins is that they are non-resorbable, and required surgical procedures to be followed for their removal after performing the required function in the subject. Some studies have been reported on polyvinylidene fluoride (PVDF) composite-based smart IM pins that are partially absorbable. But hitherto less has been reported on the compressive properties of such 3D printed PVDF composite matrix. This study reports the compressive properties of 3D printed (by using fused filament fabrication (FFF) process) PVDF composite (90% PVDF-8% Hydroxyapatite (HAp)-2% Chitosan (CS) by wt.) for a partially absorbable implant for canines. The result suggested that the best setting for the FFF process are nozzle temperature (NT) 235°C, printing speed (PS) 60 mm/s, and raster angle (RA) 45° for the compressive properties (peak load (PL) 1321 N, break load (BL) 1188.9 N, strength at peak (SP) 10.83 MPa, and strength at break (SB) 9.75 MPa). Furthermore, analysis of the PVDF composite (at 10 N load, 300 s, and 60 r/min) outlined wear of 314 µm, friction force of 1.2 N, and a coefficient of friction of 0.14 was observed. The results are supported by the morphological analysis (based on scanning electron microscopy (SEM), % of porosity, grain size No.) of the fracture site.
Quaternary copolymerized polyimides and negative photosensitive polyimides: preparation and properties
Authors: Wu Jiahao , Zhang Shiyang , Cai Mingwei , Li Qingling , Wang Zhi , Lu Xiaochuang , Min Yonggang 
Published: September 2023

Photosensitive polyimide (PSPI) have been developed base on polyimide (PI). PSPI can be used as insulating and protective materials in the microelectronics industry due to the excellent insulating properties, thermal stability, and chemical stability. In this work, we designed a synthetic method to improve the regularity of the polymer chain segment sequence. Quaternary block copolymerized precursors were prepared using condensation polymerization of poly (acid amid). A photosensitive poly (acid amid) salts (co-PAS) was also synthesized to produce patterns with photochemical reaction. After imidization, the resolution of copolymerized PSPI (co-PSPI) pattern was in the range of 16 μm–110 μm. Partial photoreactive cross-linking structure was maintained to improve the thermal stability of co-PSPI. The co-PSPI exhibited higher glass transition temperatures (327.0°C–358.8°C) than copolymerized PI (307.4°C–332.9°C). This work provides the study on the synthesis and properties of quaternary copolymerized PI and PSPI.
Non-Clinical Toxicology Evaluation of the Novel Non-ATP Competitive Oral PI3 Kinase Delta Inhibitor Roginolisib
Authors: van der Veen Lars , Schmitt Michael , Deken Marcel A. , Lahn Michael 
Published: September 2023

Roginolisib (IOA-244) is a novel, non-ATP competitive phosphoinositide-3-kinase (PI3K) delta inhibitor that regulates Akt/mTOR signaling. Roginolisib was administered once daily to rats and dogs in dose-range finding (DRF) and 4-week GLP toxicology studies. Free plasma levels of roginolisib exceeded the cellular target engagement IC90 for PI3Kδ for ≥12 hours at doses of 5 mg/kg, the IC90 for PI3Kβ for ≥2 hours at doses ≥15 mg/kg, and the IC50 for PI3Kα for ≥2 hours at dose levels ≥45 mg/kg. Toxicity in rats occurred at doses ≥100 mg/kg. In dogs, we observed dose-dependent skin and gastrointestinal toxicity and doses ≥30 mg/kg had a greater incidence of mortality. Lymphoid tissue toxicity occurred in both species. Toxicities in dogs observed at the ≥15 mg/kg dose, affecting the digestive mucosa, liver, and skin, cleared after treatment cessation. Doses ≤75 mg/kg were tolerated in rats and the no-observed-adverse-effect-level (NOAEL) in rats was 15 mg/kg. Due to mainly epithelial lesions of the skin at 5 mg/kg and necrotizing damage of the intestinal epithelia at ≥15 mg/kg, no NOAEL was determined in dogs. However, the adverse effects observed in dogs at 5 mg/kg were considered monitorable and reversible in patients with advanced malignancies. Furthermore, the PK profile subsequently proved to be a decisive factor for achieving selective PI3Kδ inhibition without the toxicities observed in dogs. As the result of the unique PK profile of roginolisib, patients were able to take daily roginolisib without dose modification and showed pharmacodynamic PI3Kδ inhibition over several months without gastrointestinal or dermatologic toxicities.
Nursing home geriatric rehabilitation care and interprofessional collaboration; a practice-based study
Authors: Drenth Hans , Krijnen Wim , van der Weerd Lourens , Reinders Jan Jaap , Hobbelen Hans 
Published: September 2023

Abstract
Background
Frailty and multimorbidity are common among patients in geriatric rehabilitation care (GRC). Proper care of these patients involves multiple professionals which requires optimal interprofessional collaboration to provide the best possible support. Interprofessional collaboration (IPC) goes beyond multi-professional collaboration. It requires professionals to think beyond the expertise of their own discipline and work on joint outcomes in which the patient is actively involved. This study describes the development of the GRC teams of an elderly care organization towards the IPC.

Methods
Mixed method pre-post study of 15 months. The interprofessional training program comprised team trainings, webinars, and online team sessions. Data was aggregated by administering the Extended Professional Identity Scale (EPIS) and QuickScan Interprofessional Collaboration (QS) measurements to GRC staff and by observations of the multi-professional team consultation (MPC) meetings of six GRC teams of an organization for elderly care in Drachten and Dokkum in the Netherlands. ADL independence (Barthel Index) and number of inpatient days were analyzed before and after the project.

Results
Pretest healthcare professional response was 106, patients for analyses was 181; posttest response was 84, patients was 170. The EPIS shows improvement on “interprofessional belonging” (P = .001, 95%CI: 0.57–2.21), “interprofessional commitment” (P = .027, 95%CI: 0.12–1.90), and overall “interprofessional identity” (P = .013, 95%CI: 0.62 − 5.20). On the QS, all domains improved; “shared values” (P = .009, 95%CI: 0.07 − 0.47), “context” (P = .005, 95%CI: 0.08 − 0.44), “structure & organization” (P = .001, 95%CI: 0.14 − 0.56), “group dynamics & interaction” (P < .001, 95%CI: 0.18 − 0.58), and “entrepreneurship & management” (P = .039, 95%CI: 0.01 − 0.48). A qualitative analysis of the reflection responses and MPC observations indicate a shift from multi-professional to more IPC. Differences in ADL over time were not statistically significant. The mean number of inpatient days was reduced by 11.8 (P < .001, 95%CI: -17.34 - − 6.31) days.

Conclusions
Within the GRC teams, there was a shift observed to more IPC and better representation of the patient’s wishes and needs. ADL independence did not change, yet we found a statistically significant decrease in the number of inpatient days. The basis for IPC was well established, however, it remains necessary that the teams continue to develop and invest in the collaboration with each other and the patient to further improve it.
Impact of cancer diagnosis and treatment: a qualitative analysis of strains, resources and coping strategies among elderly patients in a rural setting in Ghana
Authors: Mensah Adwoa Bemah Boamah , Mikare Maurice , Mensah Kofi Boamah , Okyere Joshua , Amaniampong Er-Menan , Poku Abena Agyekum , Apiribu Felix , Lamptey Joe-Nat Clegg 
Published: September 2023

Abstract
Background
Rurality is fraught with numerous difficulties including a lack of advanced health facilities to provide health services, and an absence of specialist cancer services, and qualified personnel, among others. These factors exacerbate the challenges of elderly patients diagnosed with cancer and further pose limitations to activities/instrumental activities of daily living. Yet, there is limited scholarship on the strains that affect elderly patients diagnosed with cancer and the resources that helps them to overcome them. This study explores the strains, resources, and coping strategies of elderly patients diagnosed with cancer and undergoing treatment in rural Ghana.

Methods
An exploratory, descriptive qualitative design was adopted. Purposive sampling was used to recruit 20 individuals to participate in in-depth interviews. The collected data was analysed inductively using Collaizi’s framework. QSR NVivo-12 was used in managing the data.

Results
The results were grouped into two main categories, namely: strains and resources. Within the category of strains, three main themes with their corresponding sub-themes emerged: cancer-related strains (systemic side effects from treatment, altered physical appearance and body image, and experience of pain), elderly strains (altered functional ability, limited social interactions and participation, psycho-emotional reactions, limited/restricted economic participation, and financial strains), and health system strains (negative attitude and insensitive communication, delay in diagnosis, lack of geriatric oncology care, lack of community-based specialist cancer centre and long travel distance to access care, and limited availability of essential cancer medicines and other radiations services). Four types of resources were available to cancer patients: personal resources, family resources, community resources, and healthcare systems resources.

Conclusion
In conclusion, elderly patients diagnosed with cancer experience physical, economic, psychological, and emotional strains that threaten their health and well-being. However, they are able to leverage family, community, and health system-related resources to navigate through the strains. There is, therefore, a need to expand advanced health facilities with geriatric oncology units and specialists to improve access to cancer care in rural areas. The government needs to assist elderly persons with costs associated with their diagnosis and treatment through the expansion of the National Health Insurance Scheme to include this as part of the benefits package.
Receiving hemodialysis in Hispanic ethnic dense communities is associated with better adherence and outcomes among young patients: a retrospective analysis of the Dialysis Outcomes and Practice Patterns Study
Authors: April-Sanders Ayana K. , Karaboyas Angelo , Yunes Milagros , Norris Keith C. , Dominguez Mary , Kim Ryung S. , Isasi Carmen R. , Golestaneh Ladan 
Published: September 2023

Abstract
Background
Hispanic ethnic density (HED) is a marker of better health outcomes among Hispanic patients with chronic disease. It is unclear whether community HED is associated with mortality risk among ethnically diverse patients receiving maintenance hemodialysis.

Methods
A retrospective analysis of patients in the United States cohort of the Dialysis Outcomes and Practice Patterns Study (DOPPS) database (2011–2015) was conducted (n = 4226). DOPPS data was linked to the American Community Survey database by dialysis facility zip code to obtain % Hispanic residents (HED). One way ANOVA and Kruskal Wallis tests were used to estimate the association between tertiles of HED with individual demographic, clinical and adherence characteristics, and facility and community attributes. Multivariable Cox proportional hazards models were used to estimate the mortality hazard ratio (HR) and 95% CIs by tertile of HED, stratified by age; a sandwich estimator was used to account for facility clustering.

Results
Patients dialyzing in facilities located in the highest HED tertile communities were younger (61.4 vs. 64.4 years), more commonly non-White (62.4% vs. 22.1%), had fewer comorbidities, longer dialysis vintage, and were more adherent to dialysis treatment, but had fewer minutes of dialysis prescribed than those in the lowest tertile. Dialyzing in the highest HED tertile was associated with lower hazard of mortality (HR, 0.86; 95% CI, 0.72-1.00), but this association attenuated with the addition of individual race/ethnicity (HR, 0.92; 95% CI, 0.78–1.09). In multivariable age-stratified analyses, those younger than 64 showed a lower hazard for mortality in the highest (vs. lowest) HED tertile (HR, 0.66; 95% CI, 0.49–0.90). Null associations were observed among patients ≥ 64 years.

Conclusions
Treating in communities with greater HED and racial/ethnic integration was associated with lower mortality among younger patients which points to neighborhood context and social cohesion as potential drivers of improved survival outcomes for patients receiving hemodialysis.
Clinical application of real-time PET/CT guided targeted retroperitoneal masses biopsy in diagnosing malignant tumors
Authors: Li Xiaomin , Zhang Wanchun 
Published: September 2023

Abstract
Objective
To explore the feasibility, safety, and clinical application value based on the fusion image of 18 F-FDG PET/CT, for guiding retroperitoneal puncture biopsy technology and to determine the diagnosis of retroperitoneal masses in diagnosing malignant tumors.

Methods
From March 2019 to January 2023, 42 patients underwent 18 F-FDG PET/CT imaging and were found to have retroperitoneal lesions that required definite diagnosis; 22 were male, 20 were female, and the average age was(59.17 ± 13.23) years. According to the fused 18 F-FDG PET/CT tomographic image, the target point with the highest metabolic activity, the safest, and expected maximum sample size was selected. CT scans were acquired with the same machine and fused with 18 F-FDG PET, guiding the puncture biopsy needle to approach the expected target zone, enabling timely delivery of pathological and immunohistochemical examination of the biopsy. Success rate, total examination time, biopsy operation time, complications, CT radiation dose, pathological, and immunohistochemical results were recorded.

Results
All 42 patients were sampled successfully with the successful rate being 100%. The site of sampling of 42 patients accurately targeted the highest metabolic activity, the safest, and the expected maximum sample size. All 42 patients received clear diagnosis (25 cases of malignant tumors and cases of 17 benign tissues). 15 cases of patients had a change in clinical diagnosis, accounting for 35.7% of all patients, and affecting subsequent treatment plans. The average total examination time for patients was (41.3 ± 7.3) minutes, and the biopsy operation time was (29.1 ± 8.7) minutes. The effective radiation dose generated by the entire examination generated by CT guidance was (2.0 ± 0.5) mSv; no severe complications occurred in the patients.

Conclusion
Real-time-guided retroperitoneal puncture biopsy based on 18 F-FDG PET/CT fusion image is safe, accurate, and feasible, and can provide patients of retroperitoneal mass with clear pathological diagnosis and immunohistochemical evaluation.
The prevalence of disability and associated factors among community adults in the baseline of CHCN-BTH Cohort Study
Authors: Zhu Hui-Ping , Qi Han , Liu Xiao-Hui , Liu Kuo , Li Bing-Xiao , Wen Fu-Yuan , Xie Yun-Yi , Zhang Ling 
Published: September 2023

Abstract
Background
Disability was a major public health problem in China. However, the prevalence of disabilities in community-dwelling adults and their relationships to chronic physical conditions were unclear. We aimed to estimate the prevalence of disabilities and associated factors among a large community-based cohort in China.

Methods
Participants who were local permanent residents aged 18 years or above and completed the disability assessments were selected from the Cohort study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei (CHCN-BTH) from 2017 to 2019. Disability was assessed using five questions about impairments and activity limitations based on the International Classification of Functioning (ICF), Disability and Health. Univariate, multivariate and multilevel logistic regressions were conducted to estimate the associations between disabilities and associated factors.

Results
Totally, 12,871 community-dwelling adults completed the survey. Among of them, 12.9% (95% CI: 12.3%-13.5%) reported having any disability. The prevalence of any disability was significantly higher in participants who were older age, widowed, retired and smokers, had higher BMI, average monthly income < 5000 RMB, lower education level, lower physical exercise frequency and heavy physical labor. Multilevel logistic regressions showed that there were significant associations between disabilities with chronic physical conditions, especially in the vision impairment with lower back pain, and hearing impairment as well as difficulty walking without special equipment with injuries.

Conclusions
Many Chinese adults suffered from disabilities. Sustained efforts should be made to develop specific population-based health promotion and prevention programs for disabilities in China.

Trail registration
ChiCTR1900024725 (25/07/2019).
Food-related worry and food bank use during the COVID-19 pandemic in Canada: results from a nationally representative multi-round study
Authors: Daly Zachary , Black Jennifer , McAuliffe Corey , Jenkins Emily 
Published: September 2023

Abstract
Background
Early in the COVID-19 pandemic, nearly one in five adults in Canada worried about having enough food to meet their household’s needs. Relatedly, throughout the pandemic, public messaging repeatedly urged Canadians to support food charities, including food banks. Yet few studies have examined food bank usage during the pandemic or whether food charities were widely used by Canadians worried about food access.

Methods
This study draws on four rounds of nationally representative surveying conducted during the COVID-19 pandemic between May 2020 and December 2021 among adults 18 years and older living in Canada. Descriptive statistics were used to examine rates of food-related worry during all four survey rounds. Data from the fourth survey round, collected in December 2021, were used to explore use of food-based community programs since the onset of the pandemic, including food banks. Logistic regression analyses were used to examine differences in socio-demographic and health-related characteristics between adults who did and did not report accessing food banks before and after adjusting for household income.

Results
Across survey rounds (n = 12,091), more than one in seven participants reported stress or worry related to having enough food to meet their household’s basic needs in the previous two weeks. Yet, by December 2021, fewer than 4% of participants reported ever accessing a food bank during the pandemic. Younger age, living with a child, financial concerns due to the pandemic, two different measures of food worry, pre-existing mental health conditions, disability, LGBT2Q + identity, and racialized or Indigenous identity, were each statistically significantly associated with higher odds of using food banks even when controlling for household income.

Conclusions
Despite persistently high rates of food-related worry in 2020 and 2021 in Canada, relatively few adults reported accessing food banks or other charity-based community food programs. While respondents facing social, financial, and health-related inequities and reporting food worry were more likely to use food banks, most respondents did not report food bank use, regardless of financial or demographic circumstances or experiences of food worry. Findings align with previous research indicating that more adequate and comprehensive supports are needed to alleviate food-related-worry in Canada.