bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Heavy Metal Ions Removal from Water by Improved Cuttlebone Powder with Magnetic Fe3O4 Nanoparticle as a Bioadsorbent
Authors: Didaran Aida , Sadeghi Mahnaz Sadat , Manavi Parisa Nejatkhah , Rabbani Mohammad 
Published: January 2025

AbstractScientists are constantly striving to develop improved methods for reducing or eliminating the discharge of harmful heavy metals into drinking water sources and the environment. In light of this, this study investigates the potential of utilizing a naturally available and sustainable bio‐waste material, Sepia pharaonis cuttlebone Powder (SCP), as an exceptionally effective adsorbent for the adsorption of Ni (II), Pb (II), Cu (II), and Fe (II) ions. SCP is also characterized by Fourier‐transform infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Xray diffraction (XRD), and Energy dispersive Xray (EDX) analysis. The results reveal that the highest absorption values for Ni (II), Cu (II), and Fe (II) ions are observed at pH 8, while Pb (II) ions exhibit the highest absorption at pH 4. The absorption percentage of the ions displays an increasing trend with the amount of SCP used, as well as with contact time and magnetizing SCP duration. Additionally, the addition of Fe3O4 to SCP significantly improves the absorption rate of the samples. Both Langmuir and Freundlich adsorption models are found to fit the experimental data well. Overall, SCP, with or without Fe3O4 nanoparticles, shows great promise for water remediation processes by effectively removing heavy metals.
Sedimentology of Lower Triassic (Induan Stage) Mixed Carbonate‐Siliciclastic Succession of an Epeiric Carbonate Ramp at the Northeastern Passive Margin of the Arabian Plate, Northern Iraq‐Kurdistan Region
Authors: Balaky Sardar M. , Sh. Asaad Irfan , Tamar‐Agha Mazin Y. , Radwan Ahmed E. 
Published: January 2025

ABSTRACTThe Mirga Mir Formation (Lower Triassic) was studied for its sedimentology and lithostratigraphy from two outcrops (Nazdur and Beduhe areas) c. 20 km apart, in the Northern Iraq‐Kurdistan Region. The collected samples were investigated by standard polarised microscope, X‐ray diffraction and scanning electron microscopy to infer their mineralogical characteristics, provenance and paleodepositional environments. The Mirga Mir Formation is a mixed carbonate‐siliciclastic succession consisting of thin‐, medium‐, occasionally thick‐bedded, and yellowish‐grey limestones, sandy dolomitic and argillaceous limestones, alternating with thin‐ to thick‐bedded grey shale/marl. Thin‐laminated siltstones and fine‐ to coarse‐grained sandstones are seen in the lower and middle parts of the formation. The petrographic study of carbonates and clastics (sandstones) showed that most limestones are carbonate mud (micrite). The skeletal grains consist principally of thin‐shelled pelagic bivalves (Posidonia), serpulid worm tubes (Spirorbis), microgastropods, ammonoids, calcispheres, brachiopods, dasyclad green algae, miliolid foraminifers and ostracods. Non‐skeletal grains include ooids, peloids, intraclasts and extraclasts. Depending on field observations, five different lithologic units were recognised. These are in ascending order: oolitic limestone unit, sandy limestone‐shale unit, shale‐limestone unit, argillaceous limestone‐shale unit and brecciated‐slumped limestone unit. Sandstones occur as thin beds within the lower and middle parts of the studied formation. In addition, thick coarse‐grained sandstone beds occur in the middle part of the Nazdur section only. Petrographically, thin sandstone beds consist of fine‐grained quartz. The thick sandstone bed is an immature, litharenite and consists of rock fragments (mostly sedimentary), quartz and feldspars. The X‐ray diffraction analysis and scanning electron microscope micrographs of shales revealed that the abundant clay minerals in the Mirga Mir Formation are illite, followed by kaolinite and chlorite. In addition to illite‐chlorite mixed layers, non‐clay minerals include calcite and quartz, with low feldspars. Based on detailed microfacies analysis of the limestones, 12 microfacies types from the carbonates and mixed detrital carbonates are distinguished. These facies were subdivided, according to their environmental interpretation, into five facies associations: Offshoal/basinal, Foreshoal/slope, Shoal, Back Shoal/Lagoon. The study introduces a good example of a gently sloping epeiric carbonate ramp that shows a gradual shallowing of the basin from the offshoal/basinal sediments to the foreshoal/slope and backshoal/lagoonal environments.
Blue and Green Water Scarcity in the McKenzie Creek Watershed of the Great Lakes Basin
Authors: Deen Tariq A. , Arain M. Altaf , Champagne Olivier , Chow‐Fraser Patricia , Nagabhatla Nidhi , Martin‐Hill Dawn 
Published: January 2025

ABSTRACTClimate change and extreme weather events affect hydrology and water resources in catchments worldwide. This study analysed Blue Water (BW) and Green Water (GW) scarcity in the McKenzie Creek watershed in Ontario, Canada, and explored how changes in temperature and precipitation may impact water scarcity dynamics. The McKenzie Creek is the main water source for agricultural activities for the Six Nations of the Grand River reserve (the largest Indigenous community in Canada) and other non‐Indigenous communities in the watershed. Data from the water use surveys and streamflow simulations performed using the Coupled Groundwater and Surface‐Water Flow Model (GSFLOW) under the Intergovernmental Panel on Climate Change (IPCC) Representative Concentration Pathways (RCP) scenarios 4.5 and 8.5, representing moderate and high greenhouse gas emissions and climate warming, respectively, were used to calculate BW and GW scarcity. Study results showed that BW scarcity may increase to ‘moderate’ levels if water users extract the maximum permitted water withdrawal allocation. This level of scarcity has the potential to cause ecological degradation and water quality issues in the watershed. GW scarcity will steadily increase throughout the 21st century due to climate warming with the western portion of the McKenzie Creek watershed projected to experience slightly higher levels of GW scarcity. This may cause users to withdraw more water resources, thereby decreasing BW available for downstream communities, including the Six Nations of the Grand River. This study provides water resource managers and regional planners with important information about potential challenges facing the watershed due to increased water use and changing climate conditions.
Segmentation of Brain Tumor Resections in Intraoperative 3D Ultrasound Images Using a Semisupervised Cross nnSU‐Net
Authors: Li Yuhua , Jiang Shan , Yang Zhiyong , Wang Liwen , Liu Zifeng , Zhou Zeyang 
Published: January 2025

ABSTRACTIntraoperative ultrasound (iUS) has been widely used in recent years to track intraoperative brain tissue deformation. Outlining tumor boundaries on iUS not only facilitates the robustness and accuracy of brain shift correction but also enables the direct use of iUS information for neurosurgical navigation. We developed a semisupervised cross nnU‐Net with depthwise separable convolution (SSC nnSU‐Net) for real‐time segmentation of 3D iUS images by two networks with different initialization but consistent network structure networks. Unlike previous methods, RESECT as labeled data and ReMIND as unlabeled data for hybrid dataset training selected break down the barriers between different datasets and further alleviate the problem of “data hunger.” The SSC nnSU‐Net method was evaluated by ablation of semisupervised learning, comparison with other state‐of‐the‐art methods, and model complexity. The results indicate that the proposed framework achieves a certain balance in terms of computation time, GPU memory utilization, and segmentation performance. This motivates segmentation of 3D iUS images for real‐time application in clinical surgery. The method can assist surgeons in identifying brain tumors through iUS.
Protective Effect of Transient Receptor Potential Ankyrin 1 Inhibition on Renal Ischemia Reperfusion Injury in Rats
Authors: Çakır Murat , Aydın Ali , Fırat Semanur , Şekerci Güldeniz , Bircan Burak , Öz Samet 
Published: January 2025

ABSTRACTThe transient receptor potential ankyrin 1 (TRPA1) channels, characterized as nonselective cation channels with permeability to calcium ions (Ca2 +), are part of the extensive family of transient receptor potential (TRP) channels. Research has demonstrated that TRPA1 channels function as sensors for oxidative stress in the renal tubules. Additionally, TRPA1 expression has increased in renal tissue following ischemia‐reperfusion (IR). There is also a significant correlation between IR‐induced renal injury and TRPA1 expression. This study investigated the effects of selective TRPA1 agonist ASP7663 and selective TRPA1 antagonist HC‐030031 on renal IR injury. A total of 40 rats were divided into four groups: control, IR, IR+ASP7663, and IR + HC‐030031. The rat kidneys were exposed to 45 min of ischemia, followed by 24 h of reperfusion. TRPA1 agonist ASP7663 and selective TRPA1 antagonist HC‐030031 were administered intraperitoneally to the treatment groups with renal IR. HC‐030031 administration reduced the elevated kidney injury molecule‐1 (KIM‐1), blood urea nitrogen (BUN), and creatinine (Cre) caused by renal IR. HC‐030031 administration reduced the increased histopathological damage in renal tissue due to IR. It also reduced renal tissue interleukin‐1beta (IL‐1β), interleukin‐6 (IL‐6), toll‐like receptor‐4 (TLR‐4), phosphorylated‐NF‐κB, phosphorylated‐IκB‐α, tumor necrosis factor‐alpha (TNF‐α), and caspase‐3 levels. In this study, TRPA1 antagonist HC‐030031 showed a protective behavior on renal IR injury by averting inflammation and apoptosis. After further studies, TRPA1 inhibition may be a new treatment strategy to prevent renal IR injury.
Double‐level osteotomy (DLO) for varus deformity results in over a decade of mean survival without compromising subsequent total knee arthroplasty function at a mean 26‐year follow‐up
Authors: Clark Sean C. , Simon Karissa N. , Saris Daniel B. F. , Taunton Michael J. , Krych Aaron J. , Hevesi Mario 
Published: January 2025

ABSTRACTPurposeDouble‐level osteotomies (DLOs) have shown promising results for knee joint preservation, however, most ultimately progress in terms of degenerative disease resulting in conversion to total knee arthroplasty (TKA). Therefore, the purpose of this study was to examine the time to TKA conversion, long‐term clinical outcomes and revision rates of patients who have undergone TKA after prior ipsilateral DLO.MethodsPatients who underwent simultaneous or staged DLO and subsequently underwent conversion to TKA at a single academic institution from 1997 to 2022 were evaluated. The type of osteotomy performed (opening‐ vs. closing‐wedge), osteotomy hardware fixation, when and if osteotomy hardware was removed, implanted TKA components and revision rates were recorded. Postoperative outcomes, including Forgotten Joint Score‐12 (FJS‐12), Tegner Activity Scale score and subjective knee preference were also obtained.ResultsA total of 22 patients (24 knees) underwent TKA following DLO and were followed for an average of 26.1 ± 7.7 years. The average time from DLO to TKA conversion was 14.1 ± 6.5 years, with 70.8% of knees converting to TKA more than 10 years after DLO. The mean follow‐up after conversion to TKA was 12.0 ± 7.7 years. Only 12.5% of patients received a varus‐valgus or hinged‐constrained TKA. At the final follow‐up, the mean FJS‐12 was 75.8 ± 23.1, while the mean Tegner Activity Scale score was 2.5 ± 1.1. Seventy‐seven percent of patients had no subjective knee preference or preferred their DLO‐TKA knee. Only two knees (7.4%) underwent subsequent revision after index arthroplasty at a mean of 9.3 years postoperatively.ConclusionsA majority of DLOs (70.8%) converted to TKA after more than a decade. Subsequent TKA function was favorable as most patients had either no subjective knee preference or preferred their DLO‐TKA knee. This study demonstrates both long‐term joint preservation and uncompromised TKA function after prior DLO.Level of EvidenceLevel IV.
Mental Health and Well‐Being Support for Individuals Living With Skin Conditions: A Global Landscape Analysis of Patient Needs and Current Resources
Authors: Shipowick Tammi , Austin Jennifer , Sudiacal Nicole , Miller Stephanie , Pereira Jennifer A. , Bundy Christine 
Published: January 2025

ABSTRACTThe impact of skin diseases can be devastating, encompassing physical symptoms such as bumps, rashes, hyper‐ or loss of pigmentation, redness, itch, pain and scarring. The consequences on mental health and well‐being are often more detrimental, impacting the ability to conduct routine daily activities and engage socially. Given the prevalence of dermatological conditions, it is critical that resources are available to address these needs. We conducted a review of dermatology patient advocacy groups and health organizations’ websites to determine what types of resources to support mental health and well‐being currently exist globally for individuals with skin conditions and identified 26 websites featuring resources such as sections dedicated to providing mental health information, programs on mental health topics and coping strategies, peer support forums, and counselling. Clinical trials and observational studies have demonstrated that many of these tools improve key mental health and well‐being‐related symptoms. In order for new and existing resources to be effective on a global scale, they should be delivered through methods that are sensitive to a spectrum of mental health‐related stigma, and cultural beliefs. In parts of the world where individuals value privacy above openly speaking about one's feelings, or where smartphone adoption is ubiquitous (i.e., Europe, South‐East Asia), digital health resources might hold the most potential for uptake. In regions such as Africa, and remote and rural Western Pacific, task‐shifting, a process whereby laypeople are trained by health professionals to deliver community‐based interventions, may be a promising format given mental health professional shortages. To provide optimal support for the mental health and well‐being of those around the world with skin conditions, future efforts should focus on evaluation of the patient benefits offered by existing resources, and their adaptation and expansion to befit other world regions, and align with varied cultural needs and beliefs.
Young age and return to play increase the likelihood of subsequent ACL reconstruction in football players: Data from the Swedish National Knee Ligament Registry
Authors: Fältström Anne , Forssblad Magnus , Sandon Alexander 
Published: January 2025

AbstractPurposeTo compare football players who have undergone one anterior cruciate ligament (ACL) reconstruction (ACLR) with those who have undergone a subsequent ACLR (revision or contralateral) regarding (1) demographics, (2) football‐related factors and (3) injury‐specific data.MethodsPlayers who voluntarily completed a football‐specific questionnaire available at the Swedish National Knee Ligament Registry website between April 2017 and September 2020 at the time of their primary ACL injury were included in the study. The questionnaire covered demographics, football‐related activities and injury‐specific factors. Subsequent ACLR registrations within 4 years of the primary ACLR were identified in December 2023. Data on game participation post‐primary ACLR were retrieved from the Swedish Football Association's administrative system in September 2022.ResultsA total of 992 football players (66% men) were included, of whom 99 (10%) were registered for subsequent ACLRs. Univariable analysis showed that the following factors significantly increased the odds of a subsequent ACLR: female sex, younger age, a lower weight and body mass index, fewer years played, use of knee control exercises during warm‐up, more likely to plan a return to football, more game participation registered following the primary ACLR, and shorter time between injury and ACLR. Multivariable logistic regression analysis indicated that the odds of undergoing subsequent ACLR decreased significantly with each additional year of age (odds ratio [OR], 0.87; 95% confidence interval [CI], 0.83‒0.92, p < 0.01). Players using knee control exercises during warm‐up (OR, 1.71; 95% CI, 1.08‒2.72, p = 0.02), planning to return to football (OR, 2.74; 95% CI, 1.27‒5.91, p = 0.01), and participating in games after primary ACLR (OR, 1.81; 95% CI, 1.13‒2.91, p = 0.01) increased the odds of undergoing a subsequent ACLR.ConclusionsYounger age and returning to play after an ACLR significantly increase the likelihood of undergoing a subsequent ACLR in football players.Level of EvidenceLevel IV.
Light and nutrients modulate the temperature‐sensitivity of growth in phytoplankton
Authors: Weber de Melo Vanessa , Suter Marc J.‐F. , Narwani Anita 
Published: January 2025

AbstractIn aquatic ecosystems facing climate change, higher temperatures often co‐occur with alterations in resource availability. The metabolic theory of ecology uses activation energy to assess the sensitivity of biological processes to temperature, but neglects how resource availability might modify temperature sensitivities. To understand the impacts of resource limitation on temperature sensitivities, we performed experiments manipulating temperature and three key resources (nitrogen, phosphorus, and light) in six species of freshwater phytoplankton. We measured activation energies of population growth rates and how they were modulated by resource limitation. We find that the interaction of temperature and resource limitation is dependent on the resource type. Phosphorus limitation did not modify the temperature sensitivity of growth rates, light limitation reduced the sensitivity of growth rates to temperature in all species, and nitrogen limitation had species‐dependent effects. We explore how stoichiometry and cell physiology may explain the complex responses of phytoplankton to multiple environmental changes.
Relational coordination and team‐based care: Change initiative overload and other challenges in a learning health system
Authors: Hajjar Lauren , Olaleye Olawale , Yang Julius , McGirr Susan , Sullivan Erin E. 
Published: January 2025

AbstractIntroductionMost change interventions to address quality of care and lower costs focus on technical aspects of the work through process improvements, which have not consistently delivered the anticipated impact for healthcare organizations. This study aims to (1) understand how relational interventions including shared huddles and cross‐role shadowing opportunities, impact team dynamics and functioning and (2) describe the challenges and opportunities associated with implementing relational interventions at an Academic Medical Center in a large metropolitan city in the United States.MethodsThis paper is a mixed method, pre–post‐intervention study in which data were collected using a validated survey, observations, interviews, and one focus group. Relational coordination survey data were analyzed within and across eight interdependent workgroups on three inpatient medical units at baseline and 16 months post‐intervention. Qualitative data were coded and analyzed for themes.ResultsWhile there were some improvements in overall relational coordination between baseline and post‐intervention measures, the findings were not statistically significant. Qualitative data reveal four themes, highlighting the strengths and barriers to the intervention: (1) incomplete fidelity to the relational coordination framework, (2) leadership, (3) meeting structure and participation, and (4) stakeholder engagement.ConclusionsWithin the healthcare context, this study contributes to our learning about implementing and measuring relational interventions. We offer insights for future research and practice on change initiative overload and operational constraints, socializing relational interventions, and balancing core and non‐core roles in the intervention strategy.
Rigidity in Parkinson's Disease: The Objective Effect of Levodopa
Authors: Falletti Marco , Asci Francesco , Zampogna Alessandro , Patera Martina , Pinola Giulia , Centonze Diego , Hallett Mark , Rothwell John , Suppa Antonio 
Published: January 2025

AbstractBackgroundQuantitative evidence of levodopa‐induced beneficial effects on parkinsonian rigidity in Parkinson's disease (PD) is lacking. Recent research has demonstrated the velocity‐dependent nature of objective rigidity in PD and revealed its neural underpinning.ObjectiveThe present study aimed to examine the effect of levodopa on objective rigidity in PD.MethodsEighteen patients with PD underwent clinical and instrumental evaluations of muscle tone in the OFF and ON states. The clinical assessments focused on rigidity in the most affected upper limb. The biomechanical components of objective rigidity were assessed using robot‐assisted wrist extensions at seven angular velocities (5–280°/s). Surface electromyography of the flexor carpi radialis muscle enabled the concurrent evaluation of short‐ and long‐latency stretch reflexes (SLR and LLR).ResultsLevodopa improved the clinical scores of rigidity. Biomechanical measurements showed that levodopa reduced the total and neural components of force but had no effect on viscoelastic components. Levodopa reduced the velocity dependence of the LLRs but did not affect the SLRs. Finally, we found significant clinical–instrumental correlations between levodopa‐induced changes and biomechanical and neurophysiological measures of objective rigidity in PD.ConclusionsLevodopa improved objective rigidity in PD by decreasing its biomechanical neural component as well as the size of LLRs. The beneficial effect of levodopa on biomechanical and neurophysiological features of objective rigidity was related to the specific angular velocity of wrist extensions; that is, the higher the angular velocity, the greater the beneficial impact of levodopa on objective rigidity. These findings allowed the description of a new pathophysiological model of rigidity in PD. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.