bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: A novel hybrid MDM NGPON based wavelength coding enhancemente mploying probabilistically shaped quadrature
Authors: SH  
Published: July 2023

Abstract

A smooth evolution of 16×100Gbps hybrid mode division multiplexing (MDM)/coherent-next generation passive optical network (C-NGPON) system based on wavelength complement coding is proposed. Probabilistically shaped quadrature amplitude modulation (PS-QAM) modulation established alone as the key solution to embrace advanced coherent transponders. The simulation results show that the proposed hybrid MDM/C-NGPON system can offers a high split ratio of 512 in uplink and 256 in downlink as compared to conventional passive optical networks (PONs). For legacy PON signal coexistence with PON signals as well as complement signal the minimum received power of -19dBm for uplink and − 9dBm for downlink can be obtained effectively. Also, optical to signal noise ratio (OSNR) of 20dB can be achieved forPS-512QAM as compared to uniform-shaped 128QAM at 10KHz laser linewidth and it also offers power penalty of 0.5dBunder normalized generalized mutual information (NGMI) limit of 0.857. In addition, the system offers a long-haul transmission distance of 250km considering a shaping factor of 4.7 in uplink and 4.8 in downlink, at NGMI limit. Besides this, the system throughput upto 800Gbps for uplink and 700Gbps for downlink can also be obtained successfully. Finally, it is shown that proposed work shows superiority over other existing systems.
WITHDRAWN: Investigations on PON VLC OCDMA communications
Authors: SH  
Published: July 2023

Abstract

Green and smart buildings (SBs) are promising solutions to the fast-growing and ongoing urbanization around the globe and are the composition of huge services. The SB can acquire a tremendous amount of information and perform proper handling of many broadcasting residents accordingly. With the abrupt increase in the high-quality data transmission demands over long reach for the large number of connected residents in SBs, conventional data transmission techniques are inadequate to provide adequate services. Thus, in this paper, to improve the intelligence and reliability of SBs with high overall efficiency, cost-effectiveness, and security, a hybrid passive optical network (PON) and visible light communication (VLC) indoor broadcasting system is proposed. The bidirectional hybrid PON-VLC consists of integrated time and wavelength division multiplexing (TWDM) and wavelength division multiplexing (WDM) with optical code division multiplexing (OCDMA) PON with red green blue employed light emitting diodes (RGB LEDs) based VLC system. Seven OCDMA codes are utilized in the proposed work at a 10/2.5Gbps per channel transmission rate over hybrid fiber-VLC channels to strengthen the system performance. The simulation results show that the modified new zero cross-correlation (MNZCC) code outperforms other codes and provides a faithful 100km fiber length and 5m VLC range for 200 active residents. Moreover, VLC distance can be incremented up to 10m wireless range by increasing the received aperture diameter of 25cm. Also, the numerical analysis, as well as comparative performance, depicts the superiority of PON-VLC under the impact of impairments and noise in fiber-VLC link-based SBs.
Dynamics of Research Topics in Cloud Computing Technology: Insights From Methodology of Entity Linking and Burst Detection
Authors: Coccia Mario , Roshani Saeed 
Published: July 2023

Abstract

The goal of this study is to explore emerging trends in cloud computing with applications in markets. We apply a method to analyze entity linking to extract main keywords in cloud computing in accumulated publications. Results suggest that in cloud computing research, “Internet of things” has been growing fast compared to the other topics. Moreover, Cloud Computing and Mathematical Optimization play a vital role in developing the fundamental aspects of this research fields. “Virtual Machine” also has a main role in these topics. “Computer network” with a value of 87.143, “Encryption” with a value of 82.91, “Big data” with 75.85, and “Distributed computing” are the most fast-growth research topics in the domain of Cloud Computing. These results reveal basic aspects in cloud computing, such as cloud infrastructures, hardware development, computing and software development that can foster the overall cloud computing evolution. This study also shows that virtual machines and computing device can be of critical importance in cloud computing evolution. However, the implementation of cloud computing has to be supported by skill development, organizational management, and adopter engagement (i.e., an appropriate and effective innovation ecosystem), to facilitate the general diffusion of cloud technologies and the exploitation of cloud-based infrastructures to improve productivity and efficiency of firms and other organizations. Finally, results here also can suggest implications of research policies and innovation management to support R&D investments towards new technological trajectories in cloud computing having a potential of accelerated growth and consequential benefits in socioeconomic systems.
Tropolones and Thailandepsin B as Lead-like Natural Compounds in the
Development of Potent and Selective Histone Deacetylase Inhibitors
Authors: Pal Dilipkumar , Lal Padum 
Published: July 2023

Background:
Tropolone and thailandepsin B are naturally occurring substances that are
primarily isolated from fungi and plants, although they can also be found in certain bacteria.
Tropolones belong to an important class of aromatic compounds with a seven-membered nonbenzenoid
ring structure. Thailandepsins are a group of natural products that were initially discovered
in the culture broth of the Gram-negative bacterium Burkholderia thailandensis. Tropolonebased
structures have been identified in over 200 natural compounds, ranging from simple
tropolone derivatives to complex multicyclic systems like pycnidione and pyrerubrine A.

:
These natural compounds exhibit a diverse range of pharmacological effects, including antibacterial,
antifungal, insecticidal, phytotoxic, anti-inflammatory, antimitotic, anti-diabetic, enzyme inhibitory,
anticancer, cytoprotective, and ROS scavenging properties. It is worth noting that thujaplicane,
a compound similar to tropolone, displays all of the listed biological activities except for antimitotic
action, which has only been observed in one natural tropolone compound, colchicine.

:
Tropolone can be synthesized from commercially available seven-membered rings or derived
through various cyclization and cycloaddition reactions. Thailandepsin B, on the other hand, can be
synthesized by macro-lactonization of the corresponding secoacid, followed by the formation of internal
disulfide bonds. It is important to mention that thailandepsin B exhibits different selective inhibition
profiles compared to FK228.

Objective:
We investigated the HDAC inhibitory activity of the Tropolones and Thailandepsin B
and discussed the biosynthesis of the naturally occurring compounds and their synthetic scheme.

Results and Conclusion:
It has been observed that Tropolone derivatives act as isoenzyme-selective
inhibitors of proven anticancer drug targets, histone deacetylases (HDACs). Some monosubstituted
tropolones show remarkable levels of selectivity for HDAC2 and strongly inhibit the growth
of T-lymphocyte cell lines. And Thailandepsins have different selective inhibition profiles than
FK228. They exhibit comparable inhibitory activities to FK228 against human HDAC1, HDAC2,
HDAC3, HDAC6, HDAC7, and HDAC9, but less potent inhibitory activities than FK228 toward
HDAC4 and HDAC8, the latter of which may be useful. Thailandepsins possess potent cytotoxic
activities toward some types of cell lines.
Nanotechnological Advancements for the Theranostic Intervention in
Anaplastic Thyroid Cancer: Current Perspectives and Future Direction
Authors: Uppalapati Sai Swetha , Guha Lahanya , Kumar Hemant , Mandoli Amit 
Published: July 2023

Abstract:
Anaplastic thyroid cancer is the rarest, most aggressive, and undifferentiated class of thyroid
cancer, accounting for nearly forty percent of all thyroid cancer-related deaths. It is caused by alterations
in many cellular pathways like MAPK, PI3K/AKT/mTOR, ALK, Wnt activation, and TP53
inactivation. Although many treatment strategies, such as radiation therapy and chemotherapy, have
been proposed to treat anaplastic thyroid carcinoma, they are usually accompanied by concerns such
as resistance, which may lead to the lethality of the patient. The emerging nanotechnology-based approaches
cater the purposes such as targeted drug delivery and modulation in drug release patterns
based on internal or external stimuli, leading to an increase in drug concentration at the site of the action
that gives the required therapeutic action as well as modulation in diagnostic intervention with the
help of dye property materials. Nanotechnological platforms like liposomes, micelles, dendrimers, exosomes,
and various nanoparticles are available and are of high research interest for therapeutic intervention
in anaplastic thyroid cancer. The pro gression of the disease can also be traced by using magnetic
probes or radio-labeled probes and quantum dots that serve as a diagnostic intervention in anaplastic
thyroid cancer.
The Adverse Effects and Nonmedical Use of Methylphenidate Before and After the Outbreak of COVID-19: Machine Learning Analysis
Authors: Shin Hocheol , Yuniar Cindra Tri , Oh SuA , Purja Sujata , Park Sera , Lee Haeun , Kim Eunyoung 
Published: July 2023

Background
Methylphenidate is an effective first-line treatment for attention-deficit/hyperactivity disorder (ADHD). However, many adverse effects of methylphenidate have been recorded from randomized clinical trials and patient-reported outcomes, but it is difficult to determine abuse from them. In the context of COVID-19, it is important to determine how drug use evaluation, as well as misuse of drugs, have been affected by the pandemic. As people share their reasons for using medication, patient sentiments, and the effects of medicine on social networking services (SNSs), the application of machine learning and SNS data can be a method to overcome the limitations. Proper machine learning models could be evaluated to validate the effects of the COVID-19 pandemic on drug use.

Objective
To analyze the effect of the COVID-19 pandemic on the use of methylphenidate, this study analyzed the adverse effects and nonmedical use of methylphenidate and evaluated the change in frequency of nonmedical use based on SNS data before and after the outbreak of COVID-19. Moreover, the performance of 4 machine learning models for classifying methylphenidate use based on SNS data was compared.

Methods
In this cross-sectional study, SNS data on methylphenidate from Twitter, Facebook, and Instagram from January 2019 to December 2020 were collected. The frequency of adverse effects, nonmedical use, and drug use before and after the COVID-19 pandemic were compared and analyzed. Interrupted time series analysis about the frequency and trends of nonmedical use of methylphenidate was conducted for 24 months from January 2019 to December 2020. Using the labeled training data set and features, the following 4 machine learning models were built using the data, and their performance was evaluated using F-1 scores: naïve Bayes classifier, random forest, support vector machine, and long short-term memory.

Results
This study collected 146,352 data points and detected that 4.3% (6340/146,352) were firsthand experience data. Psychiatric problems (521/1683, 31%) had the highest frequency among the adverse effects. The highest frequency of nonmedical use was for studies or work (741/2016, 36.8%). While the frequency of nonmedical use before and after the outbreak of COVID-19 has been similar (odds ratio [OR] 1.02 95% CI 0.91-1.15), its trend has changed significantly due to the pandemic (95% CI 2.36-22.20). Among the machine learning models, RF had the highest performance of 0.75.

Conclusions
The trend of nonmedical use of methylphenidate has changed significantly due to the COVID-19 pandemic. Among the machine learning models using SNS data to analyze the adverse effects and nonmedical use of methylphenidate, the random forest model had the highest performance.
Involving Health Care Professionals in the Development of Electronic Health Records: Scoping Review
Authors: Busse Theresa Sophie , Jux Chantal , Laser Johannes , Rasche Peter , Vollmar Horst Christian , Ehlers Jan P , Kernebeck Sven 
Published: July 2023

BackgroundElectronic health records (EHRs) are a promising approach to document and map (complex) health information gathered in health care worldwide. However, possible unintended consequences during use, which can occur owing to low usability or the lack of adaption to existing workflows (eg, high cognitive load), may pose a challenge. To prevent this, the involvement of users in the development of EHRs is crucial and growing. Overall, involvement is designed to be very multifaceted, for example, in terms of the timing, frequency, or even methods used to capture user preferences.ObjectiveSetting, users and their needs, and the context and practice of health care must be considered in the design and subsequent implementation of EHRs. Many different approaches to user involvement exist, each requiring a variety of methodological choices. The aim of the study was to provide an overview of the existing forms of user involvement and the circumstances they need and to provide support for the planning of new involvement processes.MethodsWe conducted a scoping review to provide a database for future projects on which design of inclusion is worthwhile and to show the diversity of reporting. Using a very broad search string, we searched the PubMed, CINAHL, and Scopus databases. In addition, we searched Google Scholar. Hits were screened according to scoping review methodology and then examined, focusing on methods and materials, participants, frequency and design of the development, and competencies of the researchers involved.ResultsIn total, 70 articles were included in the final analysis. There was a wide range of methods of involvement. Physicians and nurses were the most frequently included groups and, in most cases, were involved only once in the process. The approach of involvement (eg, co-design) was not specified in most of the studies (44/70, 63%). Further qualitative deficiencies in the reporting were evident in the presentation of the competences of members of the research and development teams. Think-aloud sessions, interviews, and prototypes were frequently used.ConclusionsThis review provides insights into the diversity of health care professionals’ involvement in the development of EHRs. It provides an overview of the different approaches in various fields of health care. However, it also shows the necessity of considering quality standards in the development of EHRs together with future users and the need for reporting this in future studies.
Effects of Sodium Chloride and Sodium Sulphate Solutions on the Output of the Electrochemical Machining
Authors: Qasim Heba saad , Aghdeab Shukry H. 
Published: July 2023

Electrochemical Machining is a term given to one of nontraditional machining that uses a chemical reaction associated with electric current to remove the material. The process is depending on the principle of anodic dissolution theory for evaluating material removal during electrochemical process. In this study, the electrochemical machining was used to remove 1 mm from the length of the a workpiece (stainless steel 316 H) by immersing it in to electrolyte (10, 20 and 30 g) of NaCl and Na2SO4 to every (1 litter of filtered water). The tool used was made from copper. Gap size between the workpiece and electrode is (0.5) mm. This study focuses on the effect of the changing the type and concentration of electrolyte solution, the effect of the value of current (2, 5 and 10) A and the effect of the value of the voltage (6, 12 and 20)V on the Surface Roughness (Ra) and Material Removal Rate (MRR) of the workpiece. The results of comparison of experimental showed that (Na2SO4) solution give surface roughness less than (NaCl) solution in all levels, maximum (Ra) is (0.658) and minimum (0.420), while (NaCl) solution give maximum (Ra) is (2.913) and minimum is (0.508), also give (MRR) higher from (NaCl) solution in level (30 g/l ) at (5 A) , (10 and 20 g/l) at (10 A) ,and (30)g/l at (6 &12 V). This study aims to compare the effect of using different electrolyte solution including sodium chloride (NaCl) and sodium sulphate (Na2SO4) on the surface roughness (Ra) and material removal rate (MRR).
Generally increasing in machining parameter (concentration of solution, current and voltage) lead to increase in (MRR) and (Ra).
Molecular detection of mononucleotide biomarkers of microsatellite instability in sporadic colorectal carcinoma patients with clinicopathological correlation
Authors: Al-Jumaili Wed Thamer Salman , Al-Musawi Bassam Musa Sadik 
Published: July 2023

Objectives: To identify the frequency and types of microsatellite instability among a group of sporadic CRC patients and to correlate the findings with clinicopathological characteristics.
Methods: During an 8-month period, all patients with sporadic CRC who attended to two teaching hospitals in Baghdad, Iraq were recruited to this cross-sectional study regardless of age, sex, ethnicity, or tumor characteristics. Demographic, clinical, and histopathological features were recorded. DNA was extracted from FFPE-blocks of the resected tumors and normal tissues. PCR amplification of five microsatellite mononucleotide repeat loci (BAT25, BAT26, NR-21, NR-24, and MONO-27) and 2 pentanucleotide repeat control markers (Penta C and Penta D) was performed to determine the MSI status. Capillary electrophoresis and Genetic Analyzer 3500 (Applied Biosystem, Japan) were used to separate and examine the products. Data were analyzed by Genescan software (Promega, USA). Instability of two or more loci is considered MSI-H.
Result: In this study, ages of the 45 recruited patients ranged between 20-80 years, with a mean±SD of 55±12.3 years; of them, 31(68.9%) were ≥50 years; 25 (55.6%) were males. Rectal bleeding was the most frequent presenting feature [22 (48.9%)] patients; 23 (51.1%) of CRCs were located at recto-sigmoid region, 29 (64.4%) were T3 tumors, 34(75.5%) were non-mucinous adenocarcinoma, 39(86.7%) were moderately differentiated, 17 (37.8%) patients had stage III tumors; and 25 (55.5%) had lymphovascular invasion. MSI-H was seen in 5/45 (11.1%) patients; 3(60%) of them were ≥50 years, 4(80%) were males, 3(60%) were smokers, 2 (40%) presented with intestinal obstruction and altered bowel habits each; 4(80%) had T3 tumors, 3(60%) had mucinous adenocarcinomas [p=0.004], 2(40%) had stage II tumor and stage III each.
Conclusion: The frequency of MSI-H among the recruited patients with CRC was 5/45 (11.1%) and it was significantly associated with mucinous adenocarcinoma subtype. NR-24 and NR-21 were the most prevalent instable markers.
Perbedaan Hasil Belajar Seni Tari Menggunakan Multimedia Interaktif Dengan Media Konvensional Pada Siswa Di SMP N 1 Talamau
Authors: Hanifa Isra , Astuti Fuji 
Published: July 2023

Penelitianainiabertujuan untuk mengetahui perbandingan hasil belajar menggunakan multimedia interaktif dengan media konvensional pada siswa kelas VIII SMP N 1 Talamau. Jenis PeneIitian ini adalah peneIitianakuantitatif. PopulasiApenelitianAini adalah seluruh siswa kelas VIII SMP N 1 Talamau. Sampel dari penelitian terdiri dari dua kelas, yaitu kelas eksperimen (VIII 3A) dan kelas kontrol (VIII 2B) ditentukan dengan cara representative (mewakili). Data dikumpulkan dengan menggunakan tes (soal objektif). Sebelum data di analisis terlebih dahulu dilakukanauji persyaratanaanalisis data berupa uji normaIitas dan uji homogenitas. HasiI peneIitian menyatakan bahwa terdapat perbedaan yang signifikan dalam penggunaan multimedia interaktif terhadap hasil belajar seni budaya siswa kelas VIII SMP N 1 Talamau dengan nilai thitung > ttabel (1,86>1,67). Dengan kata Iain penggunaan multimedia interaktif berpengaruh terhadap hasiI beIajar seni budaya siswa keIas VIII SMP N 1 Talamau. Demikian juga haInya dapat dibuktikan dengan perbedaan hasil nilai rata-rata siswa kelas VIII SMP N 1 Talamau menggunakan multimedia interaktif dengan media konvensional dengan niIai rata-rata kelas eksperimen 81,43 dan kelas kontroI 74,64. Untuk itu agar hasiI belajar seni budaya Iebih baik, makaApenggunaan multimedia interaktif harus ditingkatkan.
Encargos de aseguramiento de información financiera prospectiva en contextos inestables
Authors: Pérez Jorge O. 
Published: July 2023

Contextos inestables, como el de la economía argentina, representan riesgos significativos para las empresas que actúan en esos mercados. En los Encargos de Aseguramiento de Información Financiera Prospectiva se debe prestar especial atención a los eventos desencadenantes de una crisis macro, que podrían afectar sustancialmente la situación de las firmas examinadas.
En este trabajo se plantean instrumentos de apoyo al auditor en el reconocimiento de los riesgos mencionados y el modo de analizarlos a través de la identificación y modelización de las variables intervinientes. De esta manera, podrá tener evidencias para saber si la entidad ha considerado adecuadamente las hipótesis en relación a los efectos posibles.
Bank failure risk: A study on Silicon Valley Bank, Signature Bank, and Silvergate Capital Corporations
Authors: Hamurcu Çağri 
Published: July 2023

Abstract
This study investigates whether the ratio of long-term investment to total assets, the ratio of cash on hand to total assets, and the ratio of price-to-earnings are risk indicators for bank failures. Silicon Valley Bank (SVB), Signature Bank, and Silvergate Capital Corp., which experienced bank failure, and banks that are among the 20 largest banks in the USA are analyzed with the panel data method. Analyses were made using quarterly data between 2003Q4 and 2022Q4. It is revealed that the long-term investment to total assets ratio increases the bank failure risk. The risk of bank failure varies negatively with the cash on hand to total assets ratio. Bank failure risk rises as the price-to-earnings ratio rises. In terms of revealing the factors influencing the risk of bank failure and possible consequences, it is expected that the findings obtained could contribute to the literature.