bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Review and Meta-analysis Investigating the Impact of Oral Contraceptive Pills and Pre-treatment on In vitro Fertilisation/Intracytoplasmic Sperm Injection Outcomes
Authors: Khoja Taliah A. , Alkhomairi Summer A. , Alsaqabi Majd S. , Nagmosh Sarah J. , Alzubaidi Rahaf M. , Mortagi Rahaf M. , Alismail Fatimah M. , Alawad Fatema Hani , Ahmed Rufaida Alhafiz Alsayed M. 
Published: January 2025

Abstract

Background:
Infertility treatments such as in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) often involve preparatory interventions to enhance success rates. One such intervention, oral contraceptive pill (OCP) pre-treatment, has gained attention for its potential impact on treatment outcomes. Despite its widespread use, evidence regarding its efficacy remains inconclusive.This systematic review and meta-analysis aim to assess the impact of OCP pre-treatment on pregnancy rates in IVF/ICSI procedures. By synthesizing available evidence, this study provides insights into the implications of OCP usage within fertility treatment protocols.

Methods:
A comprehensive literature search was conducted to identify studies evaluating the effects of OCP pre-treatment in IVF/ICSI cycles. Two independent investigators extracted data on study characteristics, participant details, interventions, outcomes, and funding sources. Pregnancy rates were compared using odds ratios (ORs) and 95% confidence intervals (CI). Study quality was assessed using the Cochrane Risk of Bias Tool for Randomised Controlled Trials, ensuring transparency and reproducibility. Meta-analyses were performed using both common-effect and random-effects models to account for variability between studies.

Results:
The meta-analysis included studies reporting pregnancy rates in IVF/ICSI patients with and without OCP pre-treatment. Results showed a consistent trend across models, with a lower odds of pregnancy observed in the OCP pre-treatment group (pooled OR < 1, 95% CI). Minimal heterogeneity was noted between studies, indicating consistency in effect estimates. While publication bias was not statistically significant, potential biases in individual study designs were identified.

Conclusion:
This systematic review and meta-analysis suggest that OCP pre-treatment is associated with reduced pregnancy rates in IVF/ICSI procedures. Although findings are consistent, the clinical significance warrants cautious interpretation due to potential biases in the included studies. Further research is required to confirm these results and explore the underlying mechanisms affecting treatment outcomes.
The Efficacy of Dupilumab in Moderate-to-Severe Unresponsive Asthma Patients: A Meta-analysis of 3941 Patients
Authors: Alahdali Lama Surur H. , Althubaiti Shymaa Abdullah , Ahmasani Abdulhadi Mohammed I. , Fardan Ghadeer Mohamed , Alsaid Maryam Abotalb , Alhodibi Mostafa Habeeb 
Published: January 2025

Abstract

Background:
Dupilumab is a completely human monoclonal antibody that blocks the shared receptor component for interleukin (IL)-4 and IL-13, which are important factors in type 2 inflammation in a variety of illnesses. In this case, dupilumab’s safety and effectiveness in treating moderate-to-severe uncontrolled asthma were examined by a systematic review and meta-analysis.

Methods:
We searched PubMed, Web of Science and Scopus from the beginning until April 2024 using the following search strategy: ‘Dupilumab’ AND ‘Asthma’ to find relevant publications that needed to be screened in order to be considered for inclusion in our study.

Results:
Dupilumab showed a statistically significant higher increase in forced expiratory volume 1 s (FEV1) after treatment compared to placebo with standardised mean difference (SMD) of 1.09 (95% confidence intervals [CI]: 0.41, 1.77, P = 0.002) and I
2 = 99%, P < 0.00001. Dupilumab showed a statistically significant decrease in the Asthma Control Questionnaire (ACQ) after treatment compared to placebo with SMD of − 5.22 (95% CI: −8.35, −2.1, P = 0.001) and I
2 = 100%, P < 0.00001. Dupilumab was associated with decreased exacerbation rate compared to placebo with odds ratio of 0.53 (95% CI: 0.29, 0.99, P = 0.04) and I
2 = 70%, P = 0.03.

Conclusion:
The current study provided a comprehensive overview of dupilumab’s efficacy in individuals with moderate-to-severe asthma when compared to a placebo by pooled analysis of randomised controlled trials. We demonstrated the great effectiveness of dupilumab in this patient group that had not responded to standard therapy, as seen by improvements in FEV1, ACQ and exacerbation rates.
Robot-assisted Radical Cystectomy versus Open Radical Cystectomy: Systematic Review and Meta-analysis
Authors: Almohsen Yezeid Faisal M. , Muthaffar Amjad Hassan , Shubayli Elaf Ali , Aljefri Shatha Hassan , Almutairi Futoon Obaid , Alhamad Fay Salah , Mashraqi Khadijah Omar , Albinsaad Loai Saleh 
Published: January 2025

Abstract

Background and Objective:
The second most prevalent genitourinary cancer and the fourth most frequent cancer overall in the US is bladder cancer (BCa). The majority of patients (70%) have non-muscle-invasive BCa (NMIBC), which has a 50%–70% recurrence rate and may proceed to 10%–20% of cases to muscle-invasive BCa (MIBC). The ultimate prognosis of patients with MIBC and NMIBC is mostly influenced by surgical therapy. Although radical cystectomy (RC) has undergone numerous modifications to optimise patient outcomes in terms of cost-effectiveness, cancer control and post-operative complications, it is still a morbid procedure with a variable rate of complications. Despite this, RC is still regarded as the gold standard of care. Robot-assisted RC (RARC) is becoming more and more evidence-based, and this has made it possible to make some first judgements on how successful RARC is in comparison to open RC (ORC). This systematic review and meta-analysis aim to provide a comprehensive overview highlighting the results of RARC comparison with ORC.

Methods:
Four electronic databases, PubMed, Scopus, Cochrane Library and Web of Science were searched for relevant studies until 20 April 2024. These outcomes operative time (min), blood loss, length of stay (days) and recurrence rate were assessed. Analysis was performed using R Studio software. The data extracted were in dichotomous and continuous forms and were entered as an event and a total for the risk ratio (RR) and mean and standard deviation for mean difference (MD) between the RARC and ORC groups, along with their corresponding 95% confidence intervals (CIs) using a random model.

Results:
Eight studies were systematically reviewed and included in the meta-analysis, involving 2566 patients. Of them, 971 were drug-resistant, and 1595 were drug-sensitive. Our analysis revealed that ORC was better regarding operative time; MD was 56.28 (95% CI 33.31; 79.24, P < 0.01), while RARC was associated with lower blood loss; MD was − 203.00 (−310.03; −95.9, P < 0.001). According to the length of hospital stay and recurrence rate, none of them was superior to the other; MD was − 0.43 (95% CI − 1.70; 0.84, P = 0.5); RR was 0.99 (95% CI 0.75; 1.30, P = 0.93).

Conclusion:
Our comprehensive research found that RARC is not inferior to ORC. In addition to highlighting the significance of evidence-based decision-making in urological practice, our results provide helpful information to both doctors and patients as they navigate BCa therapy choices. This finding is considered a cornerstone for refining new surgical techniques.
A Systematic Review and Meta-analysis of Randomised Controlled Trials Comparing the Post-operative Efficacy of Ibuprofen and Acetaminophen in Paediatric Patients
Authors: Aleid Abdulsalam Mohammed , Mohammedsaleh Abdulhalim , Ajwah Yazeed Mahmoud H. , Hariri Mohammed Mustafa F. , Alawad Fatema Hani , Alshahrani Naif Yahya M , Asiri Mohammed Nasser , Al Mohaini Mohammad , Barnawi Mohammad 
Published: January 2025

Abstract

Background:
This study aimed to evaluate and compare the efficacy of ibuprofen and acetaminophen in managing post-operative pain in paediatric patients. The review seeks to determine which analgesic is more effective in reducing pain intensity, minimizing post-operative agitation, and reducing the need for additional analgesics.

Materials and Methods:
We conducted a comprehensive search across electronic databases, including PubMed, Scopus, Web of Science, and Cochrane Library. Statistical analyses were performed using R software 4.2.2. Effect sizes (Cohen’s d) and variances were calculated by first converting P values into Z-scores using Z = qnorm (1 − P/2) for two-tailed tests. Cohen’s d was then approximated as d = Z/√(n1 + n2)/2, where n1 and n2 are the sample sizes. Variance was calculated as 1/(n1 + n2). Heterogeneity was assessed with the Cochrane Q P value and I
2 statistic, using both random-effects and common effect models. Publication bias was evaluated with funnel plots and Egger’s regression test. The meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.

Results:
The meta-analysis of five studies comparing ibuprofen and acetaminophen shows mixed results. The common effect model suggests that ibuprofen may be more effective, with a significant pooled effect size of 0.2642 (95% confidence interval [CI]: 0.1128–0.4156, P = 0.0006). However, the random effects model shows a slightly higher effect size of 0.3494 but is not statistically significant (P = 0.1668) with a 95% CI crossing zero. There is significant heterogeneity amongst the studies (I
2 = 78.1%, P = 0.0011). After excluding one study, heterogeneity decreased (I
2 = 30.5%), and the common effect model still showed a small, significant advantage for ibuprofen (effect size = 0.1761, 95% CI: 0.0178–0.3344, P = 0.0292). However, the random effects model did not show statistical significance (P = 0.1597).

Conclusion:
The meta-analysis suggests that ibuprofen may have a modest edge over acetaminophen for pain management, but the findings are inconsistent and vary depending on the analytical model used. The common effect model shows a statistically significant benefit for ibuprofen, but this is not supported when the variability between studies is considered in the random effects model. The significant heterogeneity amongst the studies makes the results more complex to interpret, although this variability is reduced when one outlier study is excluded from the study. Overall, while ibuprofen appears potentially more effective, additional research is necessary to validate these results.
A Systematic Review and Meta-analysis of Randomised Controlled Trials Comparing the Post-operative Efficacy of Ibuprofen and Acetaminophen with Codeine in Paediatric Patients
Authors: Aleid Abdulsalam Mohammed , Khan Tanveer Nidal , Alabdullah Fatima Zaki , Alruwai Fatimah Essa , Alabdullah Mousa Zaki , Alshakhs Mohammed Afif , Alyousef Ali Hussain , Mohaini Mohammad Al , Albatshan Reem Sami Abdulaziz , Alkhars Ola Ahmad 
Published: January 2025

Abstract

Background:
To evaluate and compare the efficacy of ibuprofen and acetaminophen with codeine in managing post-operative pain in paediatric patients. The review seeks to determine which analgesic is more effective in reducing pain intensity, minimising post-operative agitation and reducing the need for additional analgesics.

Material and Methods:
We conducted a comprehensive search across electronic databases, including PubMed, Scopus, Web of Science and Cochrane Library. Statistical analyses were performed using R software 4.2.2. Effect sizes (Cohen’s d) and variances were calculated by first converting P values into Z-scores using Z = qnorm (1 − P/2) for two-tailed tests. Cohen’s d was then approximated as d = Z/√(n1 + n2)/2, where n1 and n2 are the sample sizes. Variance was calculated as 1/(n1 + n2). Heterogeneity was assessed with the Cochrane Q P value and I² statistic, using both random effects and common effect models. Publication bias was evaluated with funnel plots and Egger’s regression test. The meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Results:
The meta-analysis comparing ibuprofen to acetaminophen with codeine across five studies demonstrates a very small overall effect size favouring ibuprofen, with a standardised mean difference of 0.0701 (95% confidence interval: −0.0143–0.1545) in the random effects model. This effect is not statistically significant (P = 0.1034), and the confidence interval includes zero, suggesting that the observed difference may be attributable to chance. The heterogeneity assessment indicates no significant variation among studies (I² =0.0%, P = 0.4834), reflecting consistency in the results. Therefore, the analysis does not provide strong evidence for the superiority of ibuprofen over acetaminophen with codeine, as both treatments appear to offer similar efficacy.

Conclusion:
The meta-analysis indicates a minimal, statistically non-significant advantage for ibuprofen compared to acetaminophen with codeine. The results show no substantial difference between the two treatments, suggesting that both are similarly effective for pain management.
Bibliometric analysis on the top one hundred cited studies on gastrointestinal endoscopy
Authors: Sui Jing , Luo Jian-Sheng , Xiong Chao , Tang Chun-Yong , Peng Yan-Hua , Zhou Rui 
Published: January 2025

BACKGROUND
Gastrointestinal endoscopy has been widely used in the diagnosis and treatment of gastrointestinal diseases. A great many of studies on gastrointestinal endoscopy have been done.
AIM
To analyze the characteristics of top 100 cited articles on gastrointestinal endoscopy.
METHODS
A bibliometric analysis was conducted. The publications and their features were extracted from the Web of Science Core Collection, Science Citation Index-Expanded database. Excel, Web of Science database and SPSS software were used to perform the statistical description and analysis. VOSviewer software and MapChart were responsible for the visualizations.
RESULTS
The top 100 cited articles were published between 1976 and 2022. The guidelines (52%) and clinical trials (37%) are the main article types, and average publication year of the guidelines is much later than that of the clinical trials (2015 vs 1998). Among the clinical trials, diagnostic study (27.0%), cohort study (21.6%), case series (13.5%) and cross-sectional study (10.8%) account for a large proportion. Average citations of different study types and designs of the enrolled studies are of no significant differences. Most of the 100 articles were published by European authors and recorded by the endoscopic journals (65%). Top journals in medicine, such as the Lancet , New England Journal of Medicine and JAMA , also reported studies in this field. The hot spots of involved diseases include neoplasm or cancer-related diseases, inflammatory diseases, obstructive diseases, gastrointestinal hemorrhage and ulcer. Endoscopic surgery, endoscopic therapy and stent placement are frequently studied.
CONCLUSION
Our research contributes to delineating the field and identifying the characteristics of the most highly cited articles. It is noteworthy that there is a significantly smaller number of clinical trials included compared to guidelines, indicating potential areas for future high-quality clinical trials.
Microbial menace to kidney health: A review of the role of infections in acute kidney injury
Authors: Medugu N. , Adegboro B. 
Published: January 2025

Acute kidney injury (AKI) of infectious aetiology is a complex condition that requires a comprehensive microbiological evaluation. This includes sepsis workup, evaluation of urinary tract infection (UTI), assessment for viral, fungal, and bacterial infections, consideration of the patient's microbiome, and vigilance towards antibiotic toxicity. Advanced molecular diagnostic tools such as metagenomic sequencing and rapid point-of-caretesting, may offer future advances in accurate and timely identification of infectious aetiologies in AKI. Careful antibiotic selection, dosing, and duration, taking into account renal function and potential toxicity, are crucial in the era of increasing antibiotic resistance. The information presented in this review were obtained through a thorough literature search using relevant search terms on various databases including PubMed, Embase, and Cochrane Library. The review identified bacterial sepsis and UTI as common infectious syndromes associated with AKI, but also emphasized the need to consider other infectious aetiologies including viral, fungal and parasitic infections in certain clinical scenarios. The review also discussed the potential role of advanced molecular diagnostic tools in identifying infectious aetiologies in AKI and the importance of careful antibiotic selection, dosing, and duration. In conclusion, a comprehensive microbiological evaluation, coupled with the use of advanced diagnostic techniques and antibiotic stewardship, is vital for the effective management of AKI from suspected infectious aetiology, which can aid optimize patient outcomes.
Distillation plant performance implications of high distillate-purity during ethanol-water pre-concentration
Authors: Manyele Samwel Victor 
Published: January 2025

This paper presents the effect of distillate purity on the performance of ethanol-water distillation column before azeotrope. The factors affected include the required number of stages, reflux ratio, reboiler and condenser duties, investigated using different feed thermal conditions. The model was set using Aspen Plus® V10 simulation software and used to establish the impact of operating conditions due to high distillate purity. The aim was to increase distillate purity while minimizing energy consumption. The research highlights the importance of modeling and simulation for optimizing distillation processes to reduce energy consumption. The feed flow rate was 1000 kmol/h, with composition ranging from 0.1 to 0.6 mol/mol. The number of stages varied from 8 to 20 while the reflux ratio ranged between 1 and 8. The required number of stages, reflux ratio, condenser and reboiler duties increased with increasing desired distillate purity. The reboiler and condenser duties increased with distillate purity according to 3rd order polynomial functions. It was concluded that the pre-concentration column can concentrate dilute solutions to higher purity closer to the azeotropic point. Further studies were recommended on the non-linear behavior and large energy consumption.
A new chemotype of <i>Cananga odorata</i> flowers for improved extraction of essential oils with bioeconomic perspectives in Eastern Africa
Authors: Havyarimana Léopold , De Cliff Steve 
Published: January 2025

Due to its geographical position, Burundi benefits from several soil genesis factors and large variations in microclimates to which are added water resources, which give to Burundi a floral heritage of great diversity. This study therefore aimed to assess the physicochemical properties (density, refractive index, acid index and ester index) as well as the associated organoleptic characteristics (odor, color and appearance), of the essential oil extracted by hydrodistillation from fresh flowers of Annonaceae family tropical trees C. Odorata, a chemotype cultivated and grown in Bujumbura, Burundi. Analyses of physicochemical properties values were done and compared to reference values. It appears that for the refractive index, density and acid number, the findings of this study are within the pre-established standards. More interesting, the value of ester number was very beyond the norm by a factor of almost two, breaking the record already registered by AFNOR, therefore suggesting of an essential oil of exceptional quality. The findings presented in this study also highlight the importance of C. Odorata chemotype from the plains of Burundi as a promising potential candidate for bio-based products of public interests such as bio-based cosmetics and bio-based pharmaceuticals products, and therefore offer new insights bioeconomics in health and well-being. Finally, this plant can easily be cultivated, not only in Burundi, but also in countries of the Eastern Africa that share the same geoclimatic conditions as the Great African Rift.
Predictors of breast self-examination practices among female undergraduates in selected tertiary institutions in Ogun State, Nigeria: The Health Belief Model Approach
Authors: Fehintola Funmito O. , Onasoga Oluwaseun T. , Ogundele Olorunfemi. A. , Adegbenro Caleb A. 
Published: January 2025

INTRODUCTION: The study assessed the knowledge and practices of breast self-examination and predictors among female undergraduates at Olabisi Onabanjo University and Babcock University in Ogun State using the Health Belief Model.
METHODS: This descriptive cross-sectional study was conducted among 396 female undergraduates selected by multistage sampling technique. Data were collected using a pretested self-administered questionnaire and analyzed using IBM SPSS Version 25. A chi-square test was used to assess the association, while logistic regression was used to determine the predictors. A p-value of <0.05 was considered statistically significant.
RESULTS: The mean age of respondents was 16 ±2.5 years. The majority of the respondents, 292 (74.4%), had heard about breast self-examination, and more than half, 235 (59.9%) of the study participants had performed breast self-examination. Perceived susceptibility (AOR=1.62, 95%CI=1.31-1.87, p=0.003), perceived severity (AOR=1.81, 95%CI=1.53-1.91, p=0.034), perceived benefits (AOR=1.21, 95%CI=1.20-1.59, p=0.021) and perceived self -efficacy were predictors of self –breast examination (AOR=3.7, 95%CI=2.33-5.92, p<0.001).
CONCLUSION: There was low practice of breast self-examination among respondents. Constructs of the health belief model were predictors of the practice of self-breast examination. There is a need for educational programs to enhance the constructs of the health belief model that can improve the practice regarding breast self-examination.
Body Weight and Height Estimation from Second- and Fourth-Digits Length in Nigerian Children
Authors: Opoola S. O. , Adebisi S. S. , Ibegbu A. O. , Nwankwo M. 
Published: January 2025

INTRODUCTION: Accurate body weight and height estimation is crucial for pediatric healthcare, nutrition assessment, and forensic investigations. Traditional methods often rely on direct measurements, which may not always be feasible, especially in emergency or resource-limited settings. The present study aimed to develop regression equations for predicting body weight and height from the length of the second and fourth digits in male and female children in Nigeria.
METHODS: 318 male children and 336 female children between the ages of 7-15 years selected from three primary schools in Zaria local government, Kaduna state, Nigeria, were used in the study. The height of each participant was measured using a stadiometer, while body weight was measured using a bathroom scale. The length of the second digit (2D) and fourth digit (4D) of both hands in each participant was measured as the distance from the basal crease of the digit to the tip of the digit using a Vernier Calliper.
RESULTS: The result revealed that female children have significantly (P<0.05) longer 2D and 4D in both hands when compared to male children. It also showed that the body weight and height of children can be significantly (P < 0.001) predicted from the lengths of right and left 2D and 4D.
CONCLUSION: Body weight and height can be estimated from the lengths of the right and left 2D and 4D.