bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Implementation and Usability analysis of Patient Empowerment in ADLIFE project via Patient Reported Outcome Measures and Shared Decision Making
Authors: Erturkmen Gokce Banu Laleci , Juul Natassia Kamilla , Redondo Irati Erreguerena , Berastegui Dolores Verdoy , Torre Juan De La , Yuksel Mustafa , Sarigul Bunyamin , Yilmaz Gokhan , Keung Sarah N. Lim Choi , Arvanitis Theodoros N , Syse Thea Damkjaer , Sorknæs Anne Dichmann , Bloemeke Janika , Kaye Rachelle 
Published: July 2023

Abstract
Introduction:
This paper outlines the design, implementation, and usability study results of the patient empowerment process for chronic disease management, using Patient Reported Outcome Measurements and Shared Decision-Making Processes.
Background
The ADLIFE project aims to develop innovative, digital health solutions to support personalized, integrated care for patients with severe long-term conditions such as Chronic Obstructive Pulmonary Disease, and/or Chronic Heart Failure. Successful long-term management of patients with chronic conditions requires active patient self-management and a proactive involvement of patients in their healthcare and treatment. This calls for a patient-provider partnership within an integrated system of collaborative care, supporting self-management, shared-decision making, collection of patient reported outcome measures, education, and follow-up.
Methods
ADLIFE follows an outcome-based and patient-centered approach where PROMs represent an especially valuable tool to evaluate the outcomes of the care delivered. We have selected 11 standardized PROMs for evaluating the most recent patients’ clinical context, enabling the decision-making process, and personalised care planning. ADLIFE project implements the "SHARE approach’ for enabling shared decision-making via two digital platforms for healthcare professionals and patient. We have successfully integrated PROMs and shared decision-making processes to our digital toolbox, based on an international interoperability standard, namely HL7 FHIR. A usability study was conducted with 3 clinical sites with 20 users in total to gather feedback and to subsequently prioritize updates to the ADLIFE toolbox.
Results
User satisfaction is measured in the QUIS7 questionnaire on a 9-point scale in the following aspects: overall reaction, screen, terminology and tool feedback, learning, multimedia, training material and system capabilities. With all the average scores above 6 in all categories, most respondents have a positive reaction to the ADLIFE PEP platform and find it easy to use. We have identified shortcomings and have prioritized updates to the platform before clinical pilot studies are initiated.
Conclusions
Having finalized design, implementation, and pre-deployment usability studies, and updated the tool based on further feedback, our patient empowerment mechanisms enabled via PROMs and shared decision-making processes are ready to be piloted in clinal settings. Clinical studies will be conducted based at six healthcare settings across Spain, UK, Germany, Denmark, and Israel.
Rattus norvegicus reference genome evaluation for hippocampus RNA-seq data analysis
Authors: Priol Christophe Le , Delahaye-Duriez Andrée 
Published: July 2023

Abstract
Background:One of the first steps of a usual RNA-seq data analysis workflow consists in quantifying gene expression by aligning the sequencing reads to a reference genome and counting the aligned reads in its annotated regions. Downstream analysis, such as the identification of differentially expressed genes, strongly rely on the quality of this process. In addition to the performance of alignment methods, the choice of reference genome, when several of them are available, may strongly impact this step.Results:Here, we propose to evaluate the effect of widely used \Rn reference genomes consisting of Ensembl and RefSeq annotations of the Rnor\_6.0 assembly and the ones based on the mRatBN7.2 genome assembly recently published by RefSeq, on a classical differential expression workflow. We re-analyzed published RNA-seq datasets from different hippocampal subregions and revealed that the Ensembl and Refseq reference genome based on the mRatBN7.2 assembly provide an improvement of read mapping statistics. We showed that the RefSeq annotations of this assembly make gene expression quantification and differentially expressed gene identification more reliable thanks to overall longer exon length in comparison with Ensembl annotations. Moreover, we identified specific biologically relevant results using RefSeq annotations of the new genome assembly.Conclusion:Overall, the biological interpretation of the differential expression analysis of the analyzed datasets may be dramatically impacted by the choice of reference genome. Therefore, we believe that this choice should be more carefully addressed and that our approach could extend to other tissues and species.
Opsin variation in a poison frog that shows color-associated behavioral biases
Authors: Howell Kimberly A. , Richards-Zawacki Corinne L. 
Published: July 2023

Abstract

Animals send and receive signals, which are honed by evolution for detection by their intended receiver, for a variety of purposes. For signals used in mate choice, selection should favor those that are easy to detect by the receiving sex’s sensory system(s). Here we test for genetic differences affecting color vision among populations and color morphs of the polytypic poison frog, Oophaga pumilio, a species where both males and females show color-assortative behavioral biases. Opsin genes, expressed in rod and cone cells in the retina, play an important role in the tuning of color vision. We therefore hypothesized that the frog’s behavioral biases may be underlain by differences in the expression or sequences of these genes. To test this, we compared closely related populations of O. pumilio containing red and green morphs to test for convergence in opsin expression and sequence by color. We also compared opsins in sympatric morphs from two polymorphic regions with those of neighboring monomorphic populations to test for differences that would confer improved color discrimination in the polymorphic area. We found no significant differences in opsin expression among red and green populations nor among frogs from one polymorphic (red/blue) zone. However, consistent with our predictions for greater color discrimination, we found greater RH1 expression in frogs from a second polymorphic (red/yellow) region. We found several opsin sequence variants that showed no clear association with color morph, though some mutations were only found in polymorphic populations and some mutations should have significant impacts on color vision in affected individuals. Overall, we found limited evidence that differences in color vision have evolved among distinctly colored O. pumilio populations, though the variation we observed within populations does suggest that the raw material needed for selection to act on color vision is present.
Pulmonary tuberculosis complicated by extensive and multiple ground-glass opacity diagnosed by metagenomic next-generation sequencing in a patient with normal immune function: A case report
Authors: Mao Juanjuan , Jin Qian , Ye Dan , Cheng Weisong , Yang Yide 
Published: July 2023

Abstract
A 53-year-old immune-competent female presented with atypical pulmonary tuberculosis (PTB) imaging complicated by extensive and multiple clear boundary ground-glass opacity (GGO) in both lungs. Conventional diagnostic methods for infectious or non-infectious causes failed to identify the etiology. To further detect the accurate pathogen, bronchoalveolar lavage fluid (BALF) was collected for metagenomic next-generation sequencing (mNGS). Mycobacterium tuberculosis was identified by mNGS, thus the patient was diagnosed with PTB. The GGO lesions were healed after the patient received anti-tuberculosis treatment. In a follow-up after 3 months, the patient’s GGO lesion vanished. Based on these results, we for the first time reported a case of PTB in an immune-competent patient complicated by extensive and multiple GGO. And we found that mNGS was a useful complement to conventional pathogenic diagnostic methods and can be used to diagnose infections of unknown cause.
An Efficient Community Detection Algorithm in Online Social Networks
Authors: han zi-xuan , Shi Lei-lei , Liu Lu , Jiang Liang , Tang Wan , Ayorinde Ayodeji O , Antonopoulos Nick 
Published: July 2023

Abstract

The advent of social networks has brought about a paradigm shift in the conventional modes of social interaction and information exchange. Consequently, there is an increasing scholarly interest in the precise detection of communities and analysis of network structures. However, most of the prevailing methods for community detection suffer from limitations in accuracy and efficiency due to the requirement of manually configuring attribute vector dimensions during the extraction of attribute information. Moreover, these algorithms often neglect the pervasive influence of users within the global network and their capacity to disseminate information, thereby undermining the accuracy of community detection. To address these challenges, this study proposes a novel community detection algorithm, named HL Louvain, which draws upon the Hypertext Induced Topic Search (HITS) technique. The HL Louvain algorithm initially applies graph compression to the entire network and subsequently leverages the HITS algorithm to extract global node characteristics. By combining semantic attribute information with local user features, the algorithm defines the collective influence of users. This, in turn, facilitates accurate community detection by modifying the iterative approach of the conventional Louvain algorithm. Furthermore, the algorithm significantly enhances accuracy and stability by autonomously optimizing the iterative process to determine the dimensionality of the attribute vector and the number of topics within the identified network. Experimental evaluations conducted on three distinct Twitter datasets with varying degrees of complexity, as well as a public dataset, demonstrate that the HL Louvain algorithm outperforms other state-of-the-art algorithms in terms of accuracy and stability.
Enhanced Security protocols for data protection in the Internet of Healthcare Things (IoHTs) using Quantum Key Distribution
Authors: Shyry Prayla , Selvam Venkatesan , Gopinath N 
Published: July 2023

Abstract
The Internet of Healthcare Things is essential for enhancing people's protection, care, and health. Health-related criteria for patients can be remotely tracked and transferred to medical data centers via cloud storage, saving them the trip to the hospital. Additionally, the volume of data processed by Internet of Healthcare Things devices is growing exponentially. Due to the increased revelation of sensitive information, there are many unresolved issues about data security and privacy gathered through Internet of Healthcare Things devices. The requirement to apply machine learning algorithms to massive industrial data is developing as quickly as categorization methods themselves. We offer an Entangled Fuzzy Logic based Quantum Key Distribution for data protection to improve and assess the degree of security such breaches, data integrity, etc. in order to safely store and handle this information in the cloud. Results show that the proposed method enhancing the level of security to the cloud more than 99%, the works remarkably well.
Case report: Long-term survival with anlotinib in a metastatic parathyroid carcinoma patient harboring EGFR-sensitizing mutation
Authors: Ying Yushi , Li Hanning , Xia Wenfei , Cheng Teng , Li Hui , Fu Qiang , Ai Tao , Yang Yan , Zhang Ni , Li Xingrui , Ao Qilin , Du Yaying , Yang Zhifang 
Published: July 2023

Abstract

Parathyroid carcinoma (PC) is a rare and aggressive endocrine malignancy with limited treatment options. Despite the lack of standard management approaches to prevent recurrence and metastasis, current treatments such as chemotherapy and radiotherapy have demonstrated limited efficacy. Here, we report the case of a 54-year-old male patient who presented with a range of symptoms including polydipsia, polyuria, and joint pain. Further examination revealed a neck lump, hypercalcemia, and hyperparathyroidism, leading to a diagnosis of PC after en bloc surgery. Seven months following initial treatment, the patient was found to have local recurrence and distant metastases in the lung, which were subsequently resected via left lateral neck dissection and thoracoscopic wedge resection. Given the rapid progression of the patient's tumors, a 422-gene panel test was conducted, revealing the presence of epidermal growth factor receptor (EGFR) p.L858R (c. T2573G) mutation, which may sensitize the EGFR-TKI response, and PIK3CA p. E545KV(c. G1633A) mutation, which can potentially be targeted by everolimus. Despite treatment with gefitinib and everolimus, neither therapy yielded a response. After multidisciplinary treatment discussions, the patient was advised to undergo a multi-target tyrosine kinase inhibitor, anlotinib, which resulted in continuous survival benefits for 19 months. This case highlights the potential of targeted therapy to achieve long-term survival in cases of PC with distant metastases. It also underscores the importance of precision therapy guided by genome sequencing to identify potential targets for treatment. Further multicenter studies are needed to standardize the treatment of recurrent or metastatic PC.
Recommendations for Bioinformatic Tools in lncRNA Research
Authors: Distefano Rebecca , Ilieva Mirolyuba , Rennie Sarah , Uchida Shizuka 
Published: July 2023

Abstract:
Long non-coding RNAs (lncRNAs) typically refer to non-protein coding RNAs that are
longer than 200 nucleotides. Historically dismissed as junk DNA, over two decades of research have revealed
that lncRNAs bind to other macromolecules (e.g., DNA, RNA, and/or proteins) to modulate signaling
pathways and maintain organism viability. Their discovery has been significantly aided by the
development of bioinformatics tools in recent years. However, the diversity of tools for lncRNA discovery
and functional prediction can present a challenge for researchers, especially bench scientists and clinicians.
This Perspective article aims to navigate the current landscape of bioinformatic tools suitable
for both protein-coding and lncRNA genes. It aims to provide a guide for bench scientists and clinicians
to select the appropriate tools for their research questions and experimental designs.
Pola Pembentukan Akhlak pada Pesantren Di Kalimantan Selatan
Authors: Tambrin Muhammad , Hajiri Moch. Isra , Ilyasir Fiska 
Published: July 2023

<p class="abstrak">Pesantren<em> </em>merupakan lembaga pendidikan yang tidak hanya berupaya untuk mentransmisikan ilmu dan pengetahuan, akan tetapi juga mendidik dan membentuk akhlak santrinya. Penelitian ini mengambil lokasi pada pesantren yang berada di dua kota pusat pendidikan Islam Kalimantan Selatan: Pesantren Darussalam di Martapura dan Pesantren Rasyidiyah Khalidiyah di Amuntai. Pendekatan yang digunakan adalah fenomenologi dengan melakukan observasi, wawancara dan studi dokumen. Kedua pesantren membentuk akhlak santrinya melalui pendidikan dan pengajaran (kurikulum), dan membuat lingkungan yang mendukung proses tersebut. Pesantren Darussalam merupakan pesantren salafiyah dengan corak tradisional tidak mengikat terlalu ketat santrinya dengan aturan-aturan. Tujuannya adalah akhlak itu terbentuk secara alami dan melekat pada diri santri. Adapun Pesantren Rasyidiyah Khalidiyah yang bercorak modern menerapkan aturan-aturan ketat yang dimaksudkan untuk membentuk kebiasaan baik bagi santrinya. <em></em></p>
Pelatihan Menggambar Ilustrasi Cerita Rakyat untuk Pengembangan Karakter Anak-Anak Sekolah Dasar di Bali
Authors: Krisna Ari Ida Ayu Dwita , Nuriarta I Wayan 
Published: July 2023

Mesatua folklore in Bali has moral education values. The aim of this training is to draw folklore illustrations for elementary school (SD) children in Bali to preserve the mesatua tradition whose values ​​are relevant to society. This training program uses three program approaches, namely (1) Mesatua, (2) Drawing illustrations, (3) Reading children's drawings. The implementation of the program resulted in the provision of mesatua folklore in each region which was given differently according to the needs of the local environment. At the public elementary school in Budakeling village, Karangasem district, they were given the folklore I Belog, while at the public elementary school in Tukadsumaga village, Buleleng district, they were given the story The Arrogant Frog. The conclusion shows that children's illustrative work discussed line, composition, illustration, typography and color. The works produced by elementary school children in the two districts show works that are honest, expressive and free. The composition of the fields also shows that their drawings are full of freedom and confidence in drawing. Character values ​​such as not being arrogant, having to study hard and being obedient to worship are contained in the children's drawings.
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Cerita rakyat mesatua di Bali memiliki nilai pendidikan moral. Tujuan pelatihan menggambar ilustrasi cerita rakyat untuk anak-anak Sekolah Dasar (SD) di Bali adalah untuk melestarikan tradisi mesatua yang nilai-nilainya relevan dengan masyarakat. Program pelatihan ini menggunakan tiga pendekatan program, yaitu (1) mesatua, (2) menggambar ilustrasi, dan (3) membaca gambar anak. Pelaksanaan program menghasilkan pemberian cerita rakyat mesatua di masing-masing daerah diberikan secara berbeda-beda sesuai dengan kebutuhan lingkungan setempat. Di SD Negeri Desa Budakeling, Kabupaten Karangasem diberikan cerita rakyat I Belog, di SD Negeri Desa Tukadsumaga, Kabupaten Buleleng diberikan cerita Si Kodok Sombong. Simpulannya menunjukkan bahwa karya ilustrasi anak-anak dibahas garis, komposisi, ilustrasi, tipografi, dan warna. Karya-karya yang dihasilkan oleh anak-anak SD di dua kabupaten menunjukkan karya yang jujur, ekspresif, dan bebas. Komposisi bidangnya pun menunjukkan gambar mereka penuh kebebasan dan rasa percaya diri dalam menggambar. Nilai-nilai karakter seperti tidak boleh sombong, harus rajin belajar, serta taat beribadah terkandung dalam gambar anak.
The Effect of Micro and Nano Material on Critical Heat Flux (CHF) Enhancement
Authors: Sharef Enas M. , Ali Jamal M. A 
Published: July 2023

The Nano materials play a very important role in the heat transfer enhancement. An experimental investigation has been done to understand the behaviors of nano and micro materials on critical heat flux. Pool boiling experiments have used for several concentrations of nano and micro particles on a 0.4 mm diameter nickel chrome (Ni-Cr) wire heater which is heated electrically at atmospheric pressure. Zinc oxide(ZnO) and silica(SiO2) were used as a nano and micro fluids with concentrations (0.01,0.05,0.1,0.3,0.5,1 g/L), a marked enhancement in CHF have been shown in the results for nano and micro fluids for different concentrations compared to distilled water. The deposition of the nano particles on the heater surface was the reason behind the enhancement of the wettability of the surface which will increase the CHF, this nano particles deposition will form a porous layer and the mechanism of the formation of this layers is that as vapor bubbles grow, the evaporating liquid in the micro layer leaves behind Nano particles which then will be concentrated at the base of the bubble to form this pours layer. The higher wettability can produce CHF enhancement, the enhancement ratio of Nano fluid is observed to be higher than that of micro fluid, the optimum enhancement ratios of nano fluid is (1 g/l) which observed to be 9.2 % for ZnO and 8.7% for Sio2, and also (1 g/l) for micro fluid which observed to be 8.1%for ZnO and 7.4%for SiO2.
Tafakkur: A Contemplation of Students’ Spiritual and Emotional Intelligence (in The Perspective of Sufism & Transpersonal Psychology)
Authors: Nufus Dewi Hayati , Sururin Sururin , Sodiq Akhmad 
Published: July 2023

The phenomenon of the educational process creates students who frequently feel fatigue/boredom which has an impact on increasing levels of anxiety, suppression, repression, and depression. Various learning methods are applied to be able to overcome the boredom/burden of fluctuating thoughts and emotions, namely through implementing changes that tend to involve one's personal internal strength. The practice of contemplation is a training concept that is integrated with several schools. The purpose of this academic paper is to advance the concept of tafakkur in the discipline of education and establish a framework for developing instruments that enhance students' emotional and spiritual intelligence. Employing a qualitative research approach with a literature review and examination of information from Islamic scientific sources (the Qur'an and the Sunnah), as well as contemporary Islamic literature and Western literature for comparison. Description of a few previous research investigations on student therapy for anxiety and depression. Conclusions of the analysis of the concept of tafakkur from two perspectives, namely Sufism and transpersonal psychology, provide the foundation for thinking about school students' learning theory, which is inherent in the Islamic religious education curriculum because the content of tafakkur learning activities can present tawhid values, which function as the primary fundamentals of Islamic religious education. The utilization of tafakkur as a teaching tool will assist students to focus on their studies, which has implications for improving their spiritual and emotional intelligence. This provides students a strong soul and mentality as well as enables them to deal with the pressures and challenges of both the present and the future periods of globalization.
Evaluation of the Coolnet Placement Distance to Direct Evaporative Cooling to Increase Potato Seed Production in Aeroponic Systems with Root Zone Cooling in the Lowlands
Authors: Sumarni Eni , Priswanto Priswanto , Irayani Zaroh , Farid Noor 
Published: July 2023

Evaluation of the placement of the coolnet distance on direct evaporative cooling is needed in order to reduce the wilting percentage and improve seed production of potatoes. The aim of the study was to obtain the appropriate coolnet distance for the growth and development of aeroponic potato seedlings in evaporative cooling and root zone cooling applications in the tropical lowlands. The factors tested were: 1) Evaporative cooling (JEvap) distance: JEvap1 (25 cm from the top zone of the plant), JEvap2 (50 cm from the top zone), and Jevap3 (60 cm), and 2) Varieties (V): V1 (MZ), V2 (Granola K), V3 (Granola L). The design used was completely randomized design with 2 replications. Growth data and results were analyzed by the F test and continued with Duncan's Multiple Range Test (DMRT) at 5% level. The results showed that the direct evaporative cooling method and the coolnet spacing of 50-60 cm which were integrated with root zone cooling created an air temperature at the top of the plant 26-28 °C, reduced the percentage of burnt wilting, and increased the number of tubers by an average of 31.4 to 41.7 tubers/plant. Keywords: Aeroponic, cooling system, growth environment, hidroponic, limited control.