bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pembelajaran Ilmu Tajwid untuk Meningkatkan Kualitas Qira’atul Qur’an Pesantren NU Polewali Mandar
Authors: Damier Masyunida , Damier Wahyunida , Wahab Hijranah 
Published: March 2023

Penelitian ini bertujuan untuk untuk mendeskripsikan pembelajaran hukum tajwid terhadap kualitas Qira’atul Qur’an pada santri pondok Pesantren Nahdlatul Ulum Sarampu Kabupaten Polewali Mandar. Penelitian ini dilakukan di Pondok Pesantren Nahdlatul Ulum Sarampu Kabupaten Polewali Mandar. Instrumen kunci penelitian ini adalah peneliti sendiri dengan menggunakan pedoman wawancara, observasi dan beberapa dokumentasi. Adapun metode pengumpulan data riset lapangan berupa observasi, wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa dalam pembelajaran ilmu tajwid untuk meningkatkan kualitas qira’atul qur’an pada Santri Pondok Pesantren Nahdlatul Ulum Sarampu Kabupaten Polewali Mandar adalah sangat baik karena santri mampu melafalkan huruf sesuai dengan makhraj dan sifatnya. Faktor pendukung, banyaknya kitab-kitab qira’ah, pengasuh yang berkompeten sehingga lebih mudah menerapkan pembelajaran hukum tajwid. Adapun faktor penghambatnya adalah kurangnya pengasuh dan beragamnya latar belakang santri. Upaya mengatasi hambatan hukum tajwid adalah, menyiapkan pendidik yang berkualitas serta ahli dalam bidang tajwid dan menyiapkan media berupa alat peraga, proyektor dan buku panduan.
Heureux comme un enseignant dans une pédagogie « alternative » ?
Authors: Reuter Yves 
Published: March 2023

Cet article porte sur les relations entre pédagogies différentes et bonheur d’enseigner. Il s’appuie sur plusieurs recherches menées sur des établissements scolaires pratiquant des pédagogies alternatives ainsi que sur des expérimentations liées à l’article 34 de la loi « Fillon ». Plusieurs dimensions sont mises au jour : la rupture avec le mal-être vécu dans les pratiques classiques, la cohérence entre valeurs et pratiques, la place de l’engagement dans l’histoire de l’enseignant et dans ses relations personnelles, le développement professionnel, les effets sur les élèves, le rapprochement avec les familles, la reconnaissance sociale.
Bien-être scolaire et communauté éducative inclusive : défis et enjeux d’une expérimentation pédagogique à l’Île Maurice pour penser le bonheur d’enseigner
Authors: Serina-Karsky Fabienne 
Published: March 2023

Cet article s’appuie sur une recherche-action mise en place durant cinq années dans des écoles primaires de l’Île Maurice ayant mobilisé les membres de la communauté éducative ainsi que différents partenaires, à partir de laquelle se révèlent les défis et les enjeux d’une expérimentation pédagogique vectrice de bien-être dans la perspective d’une communauté éducative inclusive. L’enquête qualitative et quantitative ayant mobilisé les différents acteurs a permis de mesurer les impacts de l’expérimentation notamment sur l’environnement scolaire, le bien-être des enfants et celui des enseignants. Elle a de plus permis de montrer que la réussite de la mise en place d’une telle innovation pédagogique était corrélée à la prise en compte et à l’accompagnement de tous les acteurs de l’école

: les élèves et
leurs familles, les enseignants et leurs encadrants, les intervenants extérieurs.
Effect of Chitosan Biopolymer on Microbial Decay in Tomato (Solanum lycopersicum L.) Variety ‘Dev’ under Ambient Temperature
Authors: Meena Mahendra , Mondal Kinjal , Saharan Vinod , Meena K. K. , Gupta N. K. , Garhwal O. P. , Bairwa L. N. , Pilania Shalini , Mital . , Meena Deepak 
Published: March 2023

The current study sought to investigate the influence of chitosan biopolymer against microbial decay in tomato. In the present study, bulk-chitosan at different concentrations (0.01, 0.04, 0.08, 0.12, 0.16, 0.20% w/v) along with control were evaluated on tomato variety ՙDev՚ by dipping fruits for 6 min and stored at ambient temperature (27ºC±2). Bulk-chitosan at 0.16% was found most effective to prevent microbial decay and maintain sensory evaluation from day 1 to days 21 as compared to control. Based on the aforementioned results and comparative evaluation of different doses of bulk-chitosan, we concluded that chitosan is very effective at less concentration and thus exert minimum chemical load on the treated tomatoes. Therefore, it may claim that chitosan biopolymer have potential to protects tomato against microbial decay.
Diagnostic Yield of Exome Sequencing in Cerebral Palsy and Implications for Genetic Testing Guidelines
Authors: Gonzalez-Mantilla Pedro J. , Hu Yirui , Myers Scott M. , Finucane Brenda M. , Ledbetter David H. , Martin Christa L. , Moreno-De-Luca Andres 
Published: March 2023

ImportanceExome sequencing is a first-tier diagnostic test for individuals with neurodevelopmental disorders, including intellectual disability/developmental delay and autism spectrum disorder; however, this recommendation does not include cerebral palsy.ObjectiveTo evaluate if the diagnostic yield of exome or genome sequencing in cerebral palsy is similar to that of other neurodevelopmental disorders.Data SourcesThe study team searched PubMed for studies published between 2013 and 2022 using cerebral palsy and genetic testing terms. Data were analyzed during March 2022.Study SelectionStudies performing exome or genome sequencing in at least 10 participants with cerebral palsy were included. Studies with fewer than 10 individuals and studies reporting variants detected by other genetic tests were excluded. Consensus review was performed. The initial search identified 148 studies, of which 13 met inclusion criteria.Data Extraction and SynthesisData were extracted by 2 investigators and pooled using a random-effects meta-analysis. Incidence rates with corresponding 95% CIs and prediction intervals were calculated. Publication bias was evaluated by the Egger test. Variability between included studies was assessed via heterogeneity tests using the I2 statistic.Main Outcomes and MeasuresThe primary outcome was the pooled diagnostic yield (rate of pathogenic/likely pathogenic variants) across studies. Subgroup analyses were performed based on population age and on the use of exclusion criteria for patient selection.ResultsThirteen studies were included consisting of 2612 individuals with cerebral palsy. The overall diagnostic yield was 31.1% (95% CI, 24.2%-38.6%; I2 = 91%). The yield was higher in pediatric populations (34.8%; 95% CI, 28.3%-41.5%) than adult populations (26.9%; 95% CI, 1.2%-68.8%) and higher among studies that used exclusion criteria for patient selection (42.1%; 95% CI, 36.0%-48.2%) than those that did not (20.7%; 95% CI, 12.3%-30.5%).Conclusions and RelevanceIn this systematic review and meta-analysis, the genetic diagnostic yield in cerebral palsy was similar to that of other neurodevelopmental disorders for which exome sequencing is recommended as standard of care. Data from this meta-analysis provide evidence to support the inclusion of cerebral palsy in the current recommendation of exome sequencing in the diagnostic evaluation of individuals with neurodevelopmental disorders.
Twisted Crystalline Organic Semiconductor Photodetectors
Authors: Jeong Sehee , Barbosa Natercia , Tiwari Akash , Holland Emma K. , Huang Ling‐Yi , Bhat Vinayak , Yang Yongfan , Zhang Yuze , Whittaker St. John , Kim Min‐Woo , Alaei Aida , Sundaram Pallavi , Spencer Rochelle , Brazard Johanna , Kalyon Dilhan M. , Risko Chad , Anthony John E. , Adachi Takuji B. M. , Shtukenberg Alexander G. , Kahr Bart , Lee Stephanie S. 
Published: March 2023

AbstractOptoelectronic properties of anisotropic crystals vary with direction requiring that the orientation of molecular organic semiconductor crystals is controlled in optoelectronic device active layers to achieve optimal performance. Here, a generalizable strategy to introduce periodic variations in the out‐of‐plane orientations of 5,11‐bis(triisopropylsilylethynyl)anthradithiophene (TIPS ADT) crystals is presented. TIPS ADT crystallized from the melt in the presence of 16 wt.% polyethylene (PE) forms banded spherulites of crystalline fibrils that twist in concert about the radial growth direction. These spherulites exhibit band‐dependent light absorption, photoluminescence, and Raman scattering depending on the local orientation of crystals. Mueller matrix imaging reveals strong circular extinction (CE), with TIPS ADT banded spherulites exhibiting domains of positive or negative CE signal depending on the crystal twisting sense. Furthermore, orientation‐dependent enhancement in charge injection and extraction in films of twisted TIPS ADT crystals compared to films of straight crystals is visualized in local conductive atomic force microscopy maps. This enhancement leads to 3.3‐ and 6.2‐times larger photocurrents and external quantum efficiencies, respectively, in photodetectors comprising twisted crystals than those comprising straight crystals.
A Bispecific Peptide‐Polymer Conjugate Bridging Target‐Effector Cells to Enhance Immunotherapy
Authors: Zhang Wei , Li Dongdong , Xu Xiaodan , Chen Yong , Shi Xueying , Pan Yixuan , Yao Shasha , Piao Ying , Zhou Zhuxian , Slater Nigel K. H. , Shen Youqing , Tang Jianbin 
Published: March 2023

AbstractPeptide‐based immune checkpoint inhibitors exhibit remarkable therapeutic benefits although their application is hindered by quick blood clearance and low affinity with receptors. The modification of the peptides into artificial antibodies is an ideal platform to solve these problems, and one of the optional pathways is the conjugation of peptides with a polymer. More importantly, the bridging effect, mediated by bispecific artificial antibodies, could promote the interaction of cancer cells and T cells, which will benefit cancer immunotherapy. Herein, a bispecific peptide‐polymer conjugate (octaPEG‐PD1‐PDL1) is prepared by simultaneously conjugating PD1‐binding and PDL1‐binding peptides onto 8‐arm‐PEG. octaPEG‐PD1‐PDL1 bridges T cells and cancer cells and thus enhances T cell‐mediated cytotoxicity against cancer cells. Meanwhile, the tumor‐targeting octaPEG‐PD1‐PDL1 increases the infiltration of cytotoxic T lymphocytes in tumors and reduces their exhaustion. It effectively activates the tumor immune microenvironment and exerts a potent antitumor effect against CT26 tumor models with a tumor inhibition rate of 88.9%. This work provides a novel strategy to enhance tumor immunotherapy through conjugating bispecific peptides onto a hyperbranched polymer to effectively engage target‐effector cells.
Cartilage Lacuna‐Inspired Microcarriers Drive Hyaline Neocartilage Regeneration
Authors: Ding Sheng‐Long , Zhao Xi‐Yuan , Xiong Wei , Ji Lin‐Feng , Jia Min‐Xuan , Liu Yan‐Yan , Guo Hai‐Tao , Qu Feng , Cui Wenguo , Gu Qi , Zhang Ming‐Zhu 
Published: March 2023

AbstractCartilage equivalents from hydrogels containing chondrocytes exhibit excellent potential in hyaline cartilage regeneration, yet current approaches have limited success at reconstituting the architecture to culture nondifferentiated chondrocytes in vitro. In this study, specially designed lacunar hyaluronic acid microcarriers (LHAMCs) with mechanotransductive conditions that rapidly form stable hyaluronic acid (HA) N‐hydroxy succinimide ester (NHS‐ester) are reported. Specifically, carboxyl‐functionalized HA is linked to collagen type I via amide‐crosslinking, and gas foaming produced by ammonium bicarbonate forms concave surface of the microcarriers. The temporal 3D culture of chondrocytes on LHAMCs uniquely remodels the extracellular matrix to induce hyaline cartilaginous microtissue regeneration and prevents an anaerobic‐to‐aerobic metabolism transition in response to the geometric constraints. Furthermore, by inhibiting the canonical Wnt pathway, LHAMCs prevent β‐catenin translocation to the nucleus, repressing chondrocyte dedifferentiation. Additionally, the subcutaneous implantation model indicates that LHAMCs display favorable cytocompatibility and drive robust hyaline chondrocyte‐derived neocartilage formation. These findings reveal a novel strategy for regulating chondrocyte dedifferentiation. The current study paves the way for a better understanding of geometrical insight clues into mechanotransduction interaction in regulating cell fate, opening new avenues for advancing tissue engineering.
Single‐Crystalline BaZr0.2Ti0.8O3 Membranes Enabled High Energy Density in PEI‐Based Composites for High‐Temperature Electrostatic Capacitors
Authors: Liu Haixia , Zhu Wenxuan , Mao Qi , Peng Bin , Xu Yiwei , Dong Guohua , Chen Bohan , Peng Ruobo , Zhao Yanan , Zhou Ziyao , Yang Sen , Huang Houbing , Liu Ming 
Published: March 2023

AbstractDielectric capacitors are promising for high power energy storage, but their breakdown strength (Eb) and energy density (Ue) usually degrade rapidly at high temperatures. Adding boron nitride (BN) nanosheets can improve the Eb and high‐temperature endurance but with a limited Ue due to its low dielectric constant. Here, freestanding single‐crystalline BaZr0.2Ti0.8O3 (BZT) membranes with high dielectric constant are fabricated, and introduced into BN doped polyetherimide (PEI) to obtain laminated PEI–BN/BZT/PEI–BN composites. At room temperature, the composite shows a maximum Ue of 17.94 J cm−3 at 730 MV m−1, which is more than two times the pure PEI. Particularly, the composites exhibit excellent dielectric‐temperature stability between 25 and 150 °C. An outstanding Ue = 7.90 J cm−3 is obtained at a relatively large electric field of 650 MV m−1 under 150 °C, which is superior to the most high‐temperature dielectric capacitors reported so far. Phase‐field simulation reveals that the depolarization electric field generated at the BZT/PEI–BN interfaces can effectively reduce carrier mobility, leading to the remarkable enhancement of the Eb and Ue over a wide temperature range. This work provides a promising and scalable route to develop sandwich‐structured composites with prominent energy storage performances for high‐temperature capacitive applications.
Vincristine and dexamethasone pulses in addition to maintenance therapy among pediatric acute lymphoblastic leukemia (GD‐ALL‐2008): An open‐label, multicentre, randomized, phase III clinical trial
Authors: Qiu Kun‐yin , Wang Jia‐yi , Huang Li‐bin , Li Chang‐gang , Xu Lu‐hong , Liu Ri‐yang , Chen Hui‐qin , Ruan Yong‐sheng , Zhen Zi‐jun , Li Chi‐kong , Fang Jian‐pei 
Published: March 2023

AbstractThe efficacy and safety on the addition of vincristine (VCR) and dexamethasone (DEX) pulses to maintenance therapy among childhood acute lymphoblastic leukemia (ALL) remain uncertain. Herein, we perform an open‐label, multicentre, randomized, phase III clinical trial that was conducted at nine major medical centers in Guangdong Province, China. Patients were randomly assigned either the conventional maintenance therapy (control group, n = 384) or the VCR/DEX pulse (treatment group, n = 375). When limited to the SR cohort, 10‐year EFS was 82.6% (95% CI: 75.9–89.9) in the control group and 80.7% (95% CI: 74–88.1) in the treatment group (pnon‐inferiority = .0002). Similarly, patients with IR also demonstrated non‐inferiority of the treatment group to the control group in terms of 10‐year EFS (73.6% [95% CI: 67.6–80] vs. 77.6% [95% CI: 71.8–83.9]; pnon‐inferiority = .005). Among the HR cohort, compared with the control group, patients in the treatment group experienced a significant benefit in terms of 10‐year EFS (61.1% [95% CI: 47.7–78.2] vs. 72.6% [95% CI: 55.6–94.7], p = .026) and a trend toward higher 10‐year OS (73.8% [95% CI: 61.6–88.4] vs. 87.9% [95% CI: 579.2–97.5], p = .068). In the HR cohort, the total rate of drug‐induced liver injury and Grade 3 chemotherapy‐induced anemia were both lower for patients in the treatment group than in the control group (55.6% vs. 100%, p = .033; 37.5% vs. 60%, p = .036). Conversely, the total prevalence of chemotherapy‐induced thrombocytopenia was higher for patients in the treatment group than in the control group (88.9% vs. 40%, p = .027). Pediatric acute lymphoblastic leukemia with high risk is suitable to VCR/DEX pulse during maintenance phase for the excellent outcome, while the standard‐to‐intermediate‐risk patients could eliminate the pulses.
Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real‐world population‐based cohort
Authors: Ferreira Pamela C. L. , Zhang Yingjin , Snitz Beth , Chang Chung‐Chou H. , Bellaver Bruna , Jacobsen Erin , Kamboh M. Ilyas , Zetterberg Henrik , Blennow Kaj , Pascoal Tharick A. , Villemagne Victor L. , Ganguli Mary , Karikari Thomas K. 
Published: March 2023

AbstractIntroductionPlasma biomarkers—cost effective, non‐invasive indicators of Alzheimer's disease (AD) and related disorders (ADRD)—have largely been studied in clinical research settings. Here, we examined plasma biomarker profiles and their associated factors in a population‐based cohort to determine whether they could identify an at‐risk group, independently of brain and cerebrospinal fluid biomarkers.MethodsWe measured plasma phosphorylated tau181 (p‐tau181), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and amyloid beta (Aβ)42/40 ratio in 847 participants from a population‐based cohort in southwestern Pennsylvania.ResultsK‐medoids clustering identified two distinct plasma Aβ42/40 modes, further categorizable into three biomarker profile groups: normal, uncertain, and abnormal. In different groups, plasma p‐tau181, NfL, and GFAP were inversely correlated with Aβ42/40, Clinical Dementia Rating, and memory composite score, with the strongest associations in the abnormal group.DiscussionAbnormal plasma Aβ42/40 ratio identified older adult groups with lower memory scores, higher dementia risks, and higher ADRD biomarker levels, with potential implications for population screening.Highlights
Population‐based plasma biomarker studies are lacking, particularly in cohorts without cerebrospinal fluid or neuroimaging data.
In the Monongahela‐Youghiogheny Healthy Aging Team study (n = 847), plasma biomarkers associated with worse memory and Clinical Dementia Rating (CDR), apolipoprotein E ε4, and greater age.
Plasma amyloid beta (Aβ)42/40 ratio levels allowed clustering participants into abnormal, uncertain, and normal groups.
Plasma Aβ42/40 correlated differently with neurofilament light chain, glial fibrillary acidic protein, phosphorylated tau181, memory composite, and CDR in each group.
Plasma biomarkers can enable relatively affordable and non‐invasive community screening for evidence of Alzheimer's disease and related disorders pathophysiology.
Crystal Engineering of Two Light and Pressure Responsive Physisorbents
Authors: Castell Dominic C. , Nikolayenko Varvara I. , Sensharma Debobroto , Koupepidou Kyriaki , Forrest Katherine A. , Solanilla‐Salinas Carlos J. , Space Brian , Barbour Leonard J. , Zaworotko Michael J. 
Published: March 2023

AbstractAn emerging strategy in the design of efficient gas storage technologies is the development of stimuli‐responsive physisorbents which undergo transformations in response to a particular stimulus, such as pressure, heat or light. Herein, we report two isostructural light modulated adsorbents (LMAs) containing bis‐3‐thienylcyclopentene (BTCP), LMA‐1 [Cd(BTCP)(DPT)2] (DPT=2,5‐diphenylbenzene‐1,4‐dicarboxylate) and LMA‐2 [Cd(BTCP)(FDPT)2] (FDPT=5‐fluoro‐2,diphenylbenzene‐1,4‐dicarboxylate). Both LMAs undergo pressure induced switching transformations from non‐porous to porous via adsorption of N2, CO2 and C2H2. LMA‐1 exhibited multi‐step adsorption while LMA‐2 showed a single‐step adsorption isotherm. The light responsive nature of the BTPC ligand in both frameworks was exploited with irradiation of LMA‐1 resulting in a 55 % maximum reduction of CO2 uptake at 298 K. This study reports the first example of a switching sorbent (closed to open) that can be further modulated by light.
Modulare Synthese von strukturell diversen polyzyklischen aromatischen Kohlenwasserstoffen mit eingebetteten Azulenen durch Knoevenagelartige Kondensation
Authors: Liu Renxiang , Fu Yubin , Wu Fupeng , Liu Fupin , Zhang Jin‐Jiang , Yang Lin , Popov Alexey A. , Ma Ji , Feng Xinliang 
Published: March 2023

AbstractDas Forschungsinteresse an in polyzyklische aromatische Kohlenwasserstoffe (PAKs) eingebettete Azulene hat sich in den letzten Jahren signifikant erhöht, aber der Mangel an effizienten Synthesestrategien hemmt die Studien der Struktur‐Eigenschaftsbeziehungen sowie weiterer opto‐elektronischer Anwendungen. Wir berichten hier von einer neuen modularen Synthesestrategie für diverse Azulen‐eingebettete PAKs durch eine Tandem Suzuki Kupplung und basenvermittelte Kondensation des knoevenagel Typs in guten Ausbeuten und exzellenter struktureller Vielfalt. Die Substrate beinhalten nicht‐alternierende thiophenreiche PAKs, schmetterlings‐ und z‐förmige PAKs mit zwei Azuleneinheiten sowie das erste Beispiel zweier eingebetteter Azuleneinheiten, welche ein doppel‐[5]Helicen bilden. Die strukturelle Topologie, Aromatizität und die photophysischen Eigenschaften wurden per NMR Spektroskopie, Einkristallstrukturanalyse, UV/Vis Absorptionsspektroskopie sowie durch DFT Simulationen untersucht. Diese Strategie stellt eine neue Herangehensweise für die zügige Synthese bisher nicht erforschter, nicht‐alternierender PAKs oder Graphennanostreifen mit mehreren Azuleneinheiten dar.
Eine universelle Synthesestrategie für anpassbare metallorganische Gerüst‐Nanohybride**
Authors: Zhang Wei , Bojdys Michael J. , Pinna Nicola 
Published: March 2023

AbstractMetallorganische Gerüste (MOFs) mit eingekapselten Nanopartikeln (NPs) haben ein stark erweitertes Anwendungspotenzial in der Katalyse, Filtration und Sensorik. Die Auswahl bestimmter modifizierter Kern‐NP hat zu Teilerfolgen bei der Überwindung von Gitterfehlanpassungen geführt. Einschränkungen bei der Auswahl der NPs schränken jedoch nicht nur die Vielfalt ein, sondern beeinflussen auch die Eigenschaften der Hybridmaterialien. Hier zeigen wir eine vielseitige Synthesestrategie, bei der eine repräsentative Auswahl von sieben MOF‐Hüllen und sechs NP‐Kernen verwendet wird, die so abgestimmt sind, dass sie von einem bis zu Hunderten von Kernen in mono‐, bi‐, tri‐ und quaternäre Komposite integriert werden können. Diese Methode erfordert keine spezifischen Oberflächenstrukturen oder Funktionalitäten auf den vorgeformten Kernen. Unser Hauptanliegen ist es, die Diffusionsgeschwindigkeit alkalischer Dämpfe zu regulieren, die organische Linker deprotonieren und das kontrollierte MOF‐Wachstum und die Verkapselung von NPs auslösen. Es wird erwartet, dass diese Strategie den Weg für die Erforschung von anspruchsvolleren MOF‐Nanohybriden ebnen wird.
A Universal Synthesis Strategy for Tunable Metal‐Organic Framework Nanohybrids**
Authors: Zhang Wei , Bojdys Michael J. , Pinna Nicola 
Published: March 2023

AbstractMetal‐organic frameworks (MOFs) with encapsulated nanoparticles (NPs) enjoy a vastly expanded application potential in catalysis, filtration, and sensing. The selection of particular modified core‐NPs has yielded partial successes in overcoming lattice mismatch. However, restrictions on the choice of NPs not only limit the diversity, but also affect the properties of the hybrid materials. Here, we show a versatile synthesis strategy using a representative set of seven MOF‐shells and six NP‐cores that are fine‐tuned to incorporate from single to hundreds of cores in mono‐, bi‐, tri‐ and quaternary composites. This method does not require the presence of any specific surface structures or functionalities on the pre‐formed cores. Our key point is to regulate the diffusion rate of alkaline vapors that deprotonate organic linkers and trigger the controlled MOF‐growth and encapsulation of NPs. This strategy is expected to pave the way for the exploration of more sophisticated MOF‐nanohybrids.