bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Electroactive Species and Electrolyte Solution Chemistry Importance in Non-Aqueous Mg Electrochemical Systems
Authors: Dlugatch Ben , Kumar Yogendra , Attias Ran , Salama Michael , Btavo-Zhyvotovs Dmitry , Noked Malachi , Aurbach Doron 
Published: January 2025

Abstract
The chemistry of the electrolyte solutions that enable reversible Mg deposition is not trivial. Such solutions are currently limited to ethereal solvents and most of them contain chlorides complexes. These ionic complexes have important role in the performance. However, the presence of chlorides in these solutions complicates the cathode side because such solutions are not compatible with the commonly used metallic current collectors for cathodes. Consequently, it is questionable whether it is possible to synthesize fully functional Cl-free electrolyte solutions suitable commercial Mg-ion batteries. Noked et al. reported that by adding DME to the precursor electrolyte [Mg2Cl3*6THF]+ [Ph3AlCl]- in THF, it was possible to create a new electroactive complex Mg salt, namely, [Mg-3.DME]2+ 2[AlPh3Cl]-, which solution performs better than the precursor’s solution. This solution introduces a new case of chlorides free electrolyte solution, with stabilized Mg2+ cations and anions containing chloride ligands which cannot lead to corrosion phenomena. In this work a full evaluation of selected electrolyte solution was carried out, considering rigorously the role of the electroactive species and the anion complexes in the electrochemical process. &#xD;In addition, we study the effect of the anion on the electrochemical performance by comparing this solution with other previously presented solutions.&#xD;
Enhancement of High-Dose Chemotherapy and Autologous SCT with the PARP Inhibitor Olaparib for Refractory Lymphoma
Authors: Nieto Yago , Ramdial Jeremy , Valdez Benigno , Thall Peter F. , Bassett Roland , Barnett Melissa , Srour Samer , Hosing Chitra , Alousi Amin , Qazilbash Muzaffar , Popat Uday , Gulbis Alison , Shigle Terri Lynn , Ahmed Sairah , Guillermo Pacheco Maria , Champlin Richard , Shpall Elizabeth J. , Andersson Borje S. 
Published: January 2025

Abstract

Purpose:
More active high-dose chemotherapy (HDC) regimens are needed for autologous stem cell transplantation (ASCT) for refractory lymphomas. Seeking HDC enhancement with a PARP inhibitor, we observed marked synergy between olaparib and vorinostat/gemcitabine/busulfan/melphalan (GemBuMel) against lymphoma cell lines, mediated by the inhibition of DNA damage repair. Our preclinical work led us to clinically study olaparib/vorinostat/GemBuMel with ASCT.

Patients and Methods:
Patients ages 15 to 65 years with refractory lymphoma and adequate end-organ function were eligible for this phase I trial. The olaparib dosage was escalated from 25 mg orally twice a day on days −11 to −3, plus vorinostat (1,000 mg orally/day, days −10 to −3), gemcitabine (2,475 mg/m2/day i.v., days −8 and −3), busulfan (target AUC 4,000 µmol/L.minute−1/day i.v., days −8 to −5), melphalan (60 mg/m2/day i.v., days −3 and −2), and rituximab (CD20+ tumors; 375 mg/m2, day −10), with ASCT.

Results:
Fifty patients were enrolled (23 with Hodgkin lymphoma, 18 with diffuse large B-cell lymphoma, and 9 with T-cell non–Hodgkin lymphoma); the median age was 35 years (range, 20–61); patients received a median of three prior lines of therapy (range, 2–7); 17 patients had previously relapsed after chimeric antigen receptor T-cell therapy or other cellular immunotherapies; 23 patients had PET-positive tumors at HDC (9 in progression). An olaparib dosage of 150 mg orally twice a day was identified as the recommended phase II dosage. The main extramedullary toxicity was mucositis. The overall response rate and complete response rate were 100% and 90%, respectively. At the median follow-up of 30 (range, 12–56) months, the event-free survival and overall survival rates were 72% and 82% in all patients and 71% and 88% in patients with prior CAR T-cell failure, respectively.

Conclusions:
In this first trial combining a PARP inhibitor with HDC, olaparib/vorinostat/GemBuMel was safe and showed promising activity in refractory lymphomas, including post–CAR-T relapses.
Novel Combination Therapy Targeting Oncogenic Signaling Kinase P21-Activated Kinase 1 and Chemotherapeutic Drugs Against Triple-Negative Breast Cancer
Authors: Ezhil Inemai , Seetharaman Abirami , Kanumuri Rahul , Rajamani Barathidasan , Gangavarapu Ranga Rao , Venkatraman Ganesh , Rayala Suresh K. 
Published: January 2025

Abstract
Most of the triple-negative phenotypes or basal-like molecular subtypes of breast cancers are associated with aggressive clinical behavior and show poor disease prognosis. Current treatment options are constrained, emphasizing the need for novel combinatorial therapies for this particular tumor subtype. Our group has demonstrated that functionally active p21–activated kinase 1 (PAK1) exhibits significantly higher expression levels in clinical triple-negative breast cancer (TNBC) samples compared with other subtypes, as well as adjacent normal tissues. Low PAK1 expression in TNBC was significantly linked to better prognosis, with improved overall survival (P = 0.00236) and relapse-free survival (P = 0.0314), as shown by Gene expression–based Outcome for Breast cancer Online analysis. To confirm the role of PAK1 as a therapeutic target and to discover novel synergistic chemotherapy drug combinations, we conducted a drug combination screen using TNBC cell lines and a mouse metastatic tumor cell line. We identified the combined inhibition of PAK1 inhibitor NVS-PAK1 with doxorubicin/paclitaxel/methotrexate as a synergistic novel therapeutic approach for treating metastatic TNBC to improve overall survival. This study also indicated a reduction in the effective dosage of the chemotherapeutic drug when combined with NVS-PAK1. Our study demonstrates that combining NVS-PAK1 with each individual chemotherapeutic drug such as doxorubicin, paclitaxel, and methotrexate resulted in decreased colony formation, reduced wound-healing capability, and diminished migratory and invasive potential in both TNBC cell lines and 4T1 in vitro. These findings were further validated in orthotopic mouse mammary tumors, confirming that simultaneous PAK1 inhibition alongside chemotherapy significantly enhanced antitumor efficacy and reduced metastasis.
Nerves at Play: The Peripheral Nervous System in Extracranial Malignancies
Authors: Vermeer Paola D. , Restaino Anthony C. , Barr Jeffrey L. , Yaniv Dan , Amit Moran 
Published: January 2025

Abstract
The exponential growth of the cancer neuroscience field has shown that the host’s immune, vascular, and nervous systems communicate with and influence each other in the tumor microenvironment, dictating the cancer malignant phenotype. Unraveling the nervous system’s contributions toward this phenotype brings us closer to cancer cures. In this review, we summarize the peripheral nervous system’s contributions to cancer. We highlight the effects of nerve recruitment and tumor innervation, the neuro-immune axis, glial cell activity, and neural regulation on cancer development and progression. We also discuss harnessing the neural control of peripheral cancers as a potential therapeutic approach in oncology.
Significance: The continued and growing interest in cancer neuroscience by the scientific and medical communities reflects the rapidly accumulating interdisciplinary understanding of the nervous system’s modulation of immune, vascular, and cancer cells’ functions in malignancies. Understanding these regulatory functions can identify targets for intervention that may already be clinically available for other indications. This potential brings great excitement and hope for patients with cancer worldwide.
Cancer Research in the Age of Spatial Omics: Lessons from IMAXT
Authors: Bressan Dario ,   IMAXT Cancer Grand Challenges Consortium, Walton Nicholas , Hannon Gregory J. ,   IMAXT Cancer Grand Challenges Consortium, Al Sa’d Mohammad , Albuquerque Bruno , Ali Hamid Raza , Alini Martina , Aparicio Samuel , Ashmore Heather , Ashmore Thomas , Au Vinci , Balasubramanian Shankar , Baril Caroline , Battistoni Giorgia , Beatty Sean , Becker Robby , Bodenmiller Bernd , Bollhagen Alina , Boquetale Carla , Boyden Edward S. , Bressan Dario , Bruna Alejandra , Burger Marcel , Caldas Carlos , Callari Maurizio , Cannell Ian Gordon , Casbolt Hannah , Chornay Nick , Coutts Nikki , Dariush Ali , Deighton Lauren , Dinh Khanh N. , Duncan Natalie , Eyal-Lubling Yaniv , Falciatori Ilaria , Fan Jean , Fatemi Atefeh , Ghosh Debarati , González-Fernández Carlos , González-Solares Eduardo A. , Greenwood Wendy , Grimaldi Flaminia , Hannon Gregory J. , Harris Owen , Harris Suvi , Hemmer Nicole , Hua Kui , Irfan Melis , Jauset Cristina , Joyce Johanna A. , Kovačević Tatjana , Kuett Laura , Kunes Russell , Yoldaş Aybüke Küpcü , Lai Daniel , Laks Emma , Lee Hsuan , Lee Max , Lerda Giulia , Li Yangguang , Lovell Jack , Lu Yangning , Marioni John , McPherson Andrew , Millar Neil , Molaeinezhad Alireza , Mulvey Claire M. , Narayanan Natasha , Nogueira João C.F. , Nugent Fiona , O’Flanagan Ciara H. , Ribes Marta Paez , Pearsall Isabella , Pearsall Sarah , Pryor Brett , Qosaj Fatime , Rebbeck Clare , Roth Andrew , Rueda Oscar M. , Ruiz Teresa , Sawicka Kirsty , Sepúlveda Leonardo A. , Shah Sohrab P. , Shea Abigail , Sinha Anubhav , Smith Austin , Smith Leigh , Tavaré Simon , Vázquez-García Ignacio , Vogl Sara Lisa , Walton Nicholas A. , Watson Spencer S. , Weselak Joanna , Whitmarsh Tristan , Wild Sophia A. , Williams Elena , Windhager Jonas , Xia Chenglong , Sia Chee Ying , Zhang Chi , Zhang Ruihan , Zheng Pu , Zhuang Xiaowei 
Published: January 2025

Summary:
The Imaging and Molecular Annotation of Xenografts and Tumors Cancer Grand Challenges team was set up with the objective of developing the “next generation” of pathology and cancer research by using a combination of single-cell and spatial omics tools to produce 3D molecularly annotated maps of tumors. Its activities overlapped, and in some cases catalyzed, a spatial revolution in biology that saw new technologies being deployed to investigate the roles of tumor heterogeneity and of the tumor micro-environment.
See related article by Stratton et al., p. 22
See related article by Bhattacharjee et al., p. 28
See related article by Goodwin et al., p. 34
Implementing Mutational Epidemiology on a Global Scale: Lessons from Mutographs
Authors: Stratton Michael R. , Humphreys Laura , Alexandrov Ludmil B. , Balmain Allan , Brennan Paul , Campbell Peter J. , Phillips David H. 
Published: January 2025

Summary:
The Mutographs Cancer Grand Challenge team aimed to discover unknown causes of cancer through mutational epidemiology, an alliance of cancer epidemiology and somatic genomics. By generating whole-genome sequences from thousands of cancers and normal tissues from more than 30 countries on five continents, it discovered unsuspected mutagenic exposures affecting millions of people, raised the possibility that some carcinogens act by altering forces of selection in tissue microenvironments rather than by mutagenesis, and demonstrated changes to the direction of somatic evolution in normal cells of the human body in response to exogenous exposures and noncancer diseases.
See related article by Bressan et al., p. 16
See related article by Bhattacharjee et al., p. 28
See related article by Goodwin et al., p. 34
Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Authors: McDonald Elizabeth S. , Pan Tien-Chi , Pant Dhruv K. , Troester Melissa A. , Kossenkov Andrew V. , Mankoff David A. , Mach Robert H. , Chodosh Lewis A. 
Published: January 2025

Abstract
The ternary complex of progesterone receptor membrane component 1 (PGRMC1)–sigma-2 receptor/transmembrane protein 97 (σ2R/TMEM97)–low-density lipoprotein receptor (LDLR) has recently been discovered and plays a role in cholesterol transport. This study investigated whether individual components of that complex are prognostic breast cancer biomarkers and have defined expression in established molecular subtypes. A total of 4,463 invasive breast cancers were analyzed as a function of molecular and phenotypic markers, estimates of cellular proliferation, and recurrence-free survival. A gene expression signature–based assay was utilized to estimate cellular proliferation. Cox proportional hazards regression estimated relapse-free survival and multivariate Cox analysis adjusted for the association of proliferation with early relapse. PGRMC1–σ2R/TMEM97–LDLR expression was stratified by immunohistochemical (IHC) and molecular subtype, tumor grade, and size. TMEM97 exhibited the strongest correlation with proliferation, highest in estrogen receptor (ER)–positive disease (r = 0.59, P = 8.1−114). TMEM97 and PGRMC1 were associated with a risk of early recurrence, dependent upon their association with proliferation. The risk of early recurrence was highest with TMEM97 and only seen in ER+/HER2− disease [HR = 1.5; 95% confidence interval (CI) = 1.35–1.67; P = 5.4−14] and ER+ malignancies (HR = 1.49; 95% CI = 1.31–1.68; P = 3.1−10). There was no increased risk of recurrence with TMEM97 expression in ER−/HER2− (HR = 1.05; 95% CI = 0.88–1.25; P = 0.63) or ER− disease (HR = 1.02; 95% CI = 0.89–1.17; P = 0.75). Components of a ternary complex associated with rapid internalization of low-density lipoprotein are biomarkers associated with cellular proliferation and early recurrence, which should help guide studies exploring them in the context of additional markers of aggressive disease. Elucidating the role of PGRMC1, TMEM97, and LDLR in breast cancer will facilitate a mechanistic understanding of how proliferation interplays with cholesterol metabolism in malignant transformation or propagation.

Significance:
This first large-scale analysis of the putative ternary complex responsible for rapid low-density lipoprotein internalization in breast cancer reveals a link between component expression and recurrence, with prognostic implications for identifying patients needing supplemental posttreatment surveillance and/or additional therapeutic approaches.
Streamlining life cycle assessment for complex Mechanical Electrical and Plumbing products – Lessons from lighting
Authors: Shanker Leela , Mazzei Irene , Bowes Tim 
Published: January 2025

Life Cycle Assessment (LCA) is a framework supporting quantification of a product’s environmental impacts. Such data is required for comprehensive assessment of carbon emission impacts over the full life-cycle of products and buildings. With policymakers and the private sector pursuing decarbonisation goals, the need to streamline development of LCA data for Mechanical, Electrical and Plumbing (MEP) items has increased. MEP practitioners are tailoring existing LCA frameworks to accommodate supply chain complexity and unique use-phase scenarios. In lighting, LCA leadership is being driven by designers from consulting/engineering firms and manufacturers committed to identifying data gaps, inconsistencies, and uncertainty in the application of LCA. In 2025, lighting’s first Industry-Average LCA Report will be published as the result of an industry-led, international, collective analysis of five commonly used architectural luminaires. The findings suggest LCA development may be streamlined by articulating the role of manufacturers and designers in accelerating the closure of identified data gaps and adoption of consistent, industry-agreed interpretation of LCA for complex MEP items. Strategies include approaching industry LCA as a design innovation tool rather than compliance issue; assembling designer-manufacturer forums to incentivize commercial cooperation; improving global harmonisation and harnessing Industry-Average Environmental Product Declarations (EPDs) and other tools as an introduction to more specific analysis. Practical Application With increasing significance in the growth of, and requirement for, the adoption of Life Cycle Assessment (LCA) within the built environment, this paper offers leading practitioners and manufacturers an approach that can help identify current data gaps, areas of inconsistency and uncertainty within the discipline of Mechanical Electrical and Plumbing (MEP) LCA. It suggests how engaging multiple stakeholders, particularly manufacturers and designers, can deliver preliminary results that support wider industry progress within this emerging field of data collection and analysis. This paper also provides lighting manufacturers, sustainability specialists and MEP consultants with a more comprehensive understanding of the environmental impact of lighting.
The Importance of Spectral Match in Photometry
Authors: Nielsen Ole 
Published: January 2025

Light sources which we meet in daily life have different power spectral distribution. To achieve accuracy in photometric measurements with these sources, the spectral match should follow the curve for photopic vision, the V(λ) function. The consequence of spectral deviation is shown and the new CIE method of error definition compared to the US and Japanese definitions is discussed.
Impact of Berberine Hydrochloride-assisted Metformin on the Metabolism of Glycolipids and Serum Levels of TIMP-1 and TGF-β1 in Individuals with Type 2 Diabetes
Authors: Jie Yun , Zhang Yongwei , Yan Weichen 
Published: January 2025

Background Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and impaired glucose metabolism, leading to hyperglycemia and increased risk of complications like renal fibrosis. Purpose This study’s purpose is to examine how berberine hydrochloride (BBR) and metformin (Met) work together to treat T2DM, as well as how these medications affect tissue type metalloproteinase-1 (TIMP-1), glucose, and lipid metabolism levels in the blood and transforming growth factor β1. Methods Using a random number table approach, overall, 100 individuals with T2DM between October 2020 and October 2022 were chosen and classified into two groups: An experimental group and an untreated group, each with 50 patients. The untreated group received Met therapy, whereas the experimental group received BBR based on the untreated group. The two groups were compared regarding efficacy, cholesterol and glucose metabolism, renal function and renal fibrosis indices, and the frequency of adverse responses. Results The experimental group’s effective rate was 96.00% higher than that of the untreated group (82.00%). Following treatment, the experimental group had lower levels of glycosylated hemoglobin (HbAlc), insulin resistance index (HOMA-IR), fasting blood glucose (FBG), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and cholesterol (TC) than the untreated group, while the untreated group had greater levels of high-density lipoprotein cholesterol (HDL-C). Following the course of therapy, the observation group’s levels of cystatin (Cys-C), urinary β2 microglobulin (β2-MG), urine albumin excretion rate (UAER), and urinary microalbumin (ALB) were all lesser compared to the untreated group. Following treatment, the experimental group’s transforming growth factor-β (TGF-β) levels, matrix metalloproteinase-9 (MMP-9), and TIMP-1 were lesser than those of the untreated group. Conclusion When Met and BBR are taken together, patients with type 2 diabetes can effectively control their glucose and lipid metabolism, as well as their levels of TGF-β1, MMP-9, and TIMP-1. They can also postpone renal interstitial fibrosis and eventually improve their kidney function, all with a high degree of safety and significant effects.
Unlocking Nutraceutical Potential: Metabolomic Analysis Reveals Therapeutic Compounds in Rice
Authors: Faseela Konganam Veedu , Berin Pathrose , Jayadeep Appukuttan , Biju Sidharthan , Jiji Joseph , Abida P. S. , Deepu Mathew 
Published: January 2025

Background Rice varieties enriched with potential bioactive compounds are poised to make a significant contribution to global health. It is anticipated that edible medications made from rice seeds will lead to novel therapeutics. Purpose High-yielding popular pigmented and nonpigmented rice varieties were selected for in-depth analysis of bioactive contents. Nutraceutical potential of high-yielding rice varieties often goes underexplored compared to low-yielding specialty rice varieties. This study addresses the gap by metabolomic profiling of popular rice varieties to uncover bioactive compounds with significant pharmaceutical and nutritional benefits. Methods Untargeted metabolomic profiling of the brown rice of pigmented and nonpigmented varieties was conducted by Orbitrap-high-resolution liquid chromatography and mass spectrometry, and primary and secondary metabolites were identified and annotated. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging (RS) assay was carried out to identify the variety with superior antioxidant activity. Correlation analysis by using Metaboanalyst software identified major metabolites with RS potential. Over-representation analysis was performed for the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and major pathways were identified for metabolites with nutraceutical potential in pigmented rice. Results Major metabolites with antioxidant, anti-inflammatory, and anticarcinogenic properties were identified from rice varieties. Bioactive compounds detected from brown rice included choline, didodecyl-3,3-thiodipropionate, conjugated linoleic acid, oleic acid, 13( S)-HOTrE, monoolein, nicotinic acid, pantothenic acid, isoquinoline, trigonelline, corymboside, ferulic acid, and 2,4-quinolinediol. The DPPH RS assay revealed superior antioxidant activity in the pigmented rice, with differential metabolites from the pathways of phenylpropanoid biosynthesis, arginine and proline metabolism, and biosynthesis of unsaturated fatty acids showing a significant correlation ( p < .01) with RS potential. Conclusion Catechin, (–)-epicatechin, (±)12(13)-DiHOME, 4-guanidinobutyric acid, and 5-methoxysalicylic acid are key metabolites that emphasize the antioxidant potential of red-colored rice as a functional food with significant health benefits. The study highlights the therapeutic promise of pigmented whole-grain rice.