bluuebunny/crossref_metadata_2025_split huggingface dataset:
No Delayed Ruptures on Long-Term Follow-Up of a Case Series of Persistently Filling Saccular Internal Carotid Artery Aneurysms After Flow Diversion With the Pipeline Embolization Device
Authors: Lee Ryan P. , Bhimreddy Meghana , Kim Jennifer , Wicks Robert T. , Xu Risheng , Bender Matthew , Yang Wuyang , Sattari Shahab Aldin , Hung Alice , Jackson Christopher M. , Gonzalez L. Fernando , Huang Judy , Tamargo Rafael , McDougall Cameron G. , Caplan Justin M. 
Published: May 2023

BACKGROUND AND OBJECTIVES:
Flow diversion of intracranial aneurysms results in high occlusion rates. However, 10% to 20% remain persistently filling at 1 year. Often, these are retreated, but benefits of retreatment are not well established. A better understanding of the long-term rupture risk of persistently filling aneurysms after flow diversion is needed.

METHODS:
Our institutional database of 974 flow diversion cases was queried for persistently filling saccular aneurysms of the clinoidal, ophthalmic, and communicating segments of the internal carotid artery treated with the pipeline embolization device (PED, Medtronic). Persistent filling was defined as continued flow into the aneurysm on 1 year catheter angiogram. The clinical record was queried for retreatments and delayed ruptures. Clinical follow-up was required for at least 2 years.

RESULTS:
Ninety-four persistent aneurysms were identified. The average untreated aneurysm size was 5.6 mm. A branch vessel originated separately in 55% of cases from the body of the aneurysm in 10.6% of cases and from the neck in 34% of cases. Eighteen percent of aneurysms demonstrated >95% filling at 1 year, and 61% were filling 5% to 95% of their original size. The mean follow-up time was 4.9 years, including 41 cases with >5 years. No retreatment was undertaken in 91.5% of aneurysms. There were no cases of delayed subarachnoid hemorrhage.

CONCLUSION:
Among saccular internal carotid artery aneurysms treated with PED that demonstrated persistent aneurysm filling at 1 year, there were no instances of delayed rupture on long-term follow-up. These data suggest that observation may be appropriate for continued aneurysm filling at least in the first several years after PED placement.
In Cardiac Patients Beta-Blockers Attenuate the Decrease in Work Rate during Exercise at a Constant Submaximal Heart Rate
Authors: Baldassarre Giovanni , Azzini Valeria , Zuccarelli Lucrezia , Degano Cristina , Graniero Francesco , Plett Gloria , Floreani Mirco , Lazzer Stefano , Mos Lucio , Grassi Bruno 
Published: May 2023

ABSTRACT

Purpose
Exercise prescription based on fixed heart rate (HR) values is not associated with a specific work rate (WR) during prolonged exercise. This phenomenon has never been evaluated in cardiac patients, and might be associated with a slow component of HR kinetics and -adrenergic activity. The aim was to quantify, in cardiac patients, the work rate decrease at a fixed HR, and to test if it would be attenuated by β-blockers.

Methods
17 patients with coronary artery disease in stable conditions (69 ± 9 yr) were divided into two groups according to the presence (BB) or absence (no-BB) of a therapy with β-blockers, and performed on a cycle ergometer: an incremental exercise (INCR); a 15-min “HRCLAMPED” exercise, in which WR was continuously adjusted to maintain a constant HR, corresponding to the gas exchange threshold (GET) +15%. HR was determined by the ECG signal, and pulmonary gas exchange was assessed breath-by-breath.

Results
During INCR HRpeak was lower in BB vs. no-BB (p < 0.05), whereas no differences were observed for other variables. During HRCLAMPED the decrease in WR needed to maintain HR constant was less pronounced in BB vs. no-BB (-16 ± 10% vs. -27 ± 10, p = 0.04), and was accompanied by a decreased

O2 only in no-BB (-13 ± 6%, p < 0.001).

Conclusions
The decrease in WR during 15-min exercise at a fixed HR (slightly higher than that at GET) was attenuated in BB, suggesting a potential role by β-adrenergic stimulation. The phenomenon may represent, also in this population, a sign of impaired exercise tolerance, and interferes with aerobic exercise prescription.
Direct and Spillover Effects of Quality Disclosure Regulation: Evidence from California Hospitals
Authors: Deore Aishwarrya , Holzhacker Martin , Krishnan Ranjani 
Published: May 2023

Quality disclosures regarding medical outcomes such as patient mortality are common healthcare policy instruments. Mixed evidence exists on whether quality disclosures improve outcomes for disclosed ailments. Moreover, disclosure policies can generate spillovers and impact ailments not targeted by the policy. We examine the effects of quality disclosure regulation on mortality improvements in disclosed and nondisclosed ailments. We use patient records for California hospitals for 1995–2014 and construct three groups of ailments: those that were the target of disclosure regulation, complementary ailments that were not the target of disclosure regulation but are medically related to the disclosed ailments, and medically unrelated ailments. Using a difference-in-differences design, we find that quality disclosure regulation is associated with declines in mortality risk of disclosed ailments ranging from 11.5% to 23%. Quality disclosure regulation is also associated with improvements for complementary ailments that are not the target of the disclosure policy. Such positive spillover effects yield an estimated 15.2% decline in mortality risk. Consistent with demand-side pressures driving improvements, market shares become sensitive to disclosed quality measures after disclosure regulation. Our findings of direct and spillover effects have implications for disclosure regulation. This paper was accepted by David Simchi-Levi, accounting. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4817 .
Non-Bayesian Statistical Discrimination
Authors: Campos-Mercade Pol , Mengel Friederike 
Published: May 2023

Models of statistical discrimination typically assume that employers make rational inference from (education) signals. However, there is a large amount of evidence showing that most people do not update their beliefs rationally. We use a model and two experiments to show that employers who are conservative, in the sense of signal neglect, discriminate more against disadvantaged groups than Bayesian employers. We find that such non-Bayesian statistical discrimination deters high-ability workers from disadvantaged groups from pursuing education, further exacerbating initial group inequalities. Excess discrimination caused by employer conservatism is especially important when signals are very informative. Out of the overall hiring gap in our data, around 40% can be attributed to Bayesian statistical discrimination, a further 40% is due to non-Bayesian statistical discrimination, and the remaining 20% is unexplained or potentially taste-based. This paper was accepted by Marie Claire Villeval, behavioral economics and decision analysis. Funding: F. Mengel thanks the European Research Council for financial support [Starting Grant 805017]. P. Campos-Mercade acknowledges funding from the Danish National Research Foundation [Grant DNRF134 (CEBI)]. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4824 .
Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation
Authors: Altcheh Jaime , Moscatelli Guillermo , Caruso Martin , Moroni Samanta , Bisio Margarita , Miranda Maria Rosa , Monla Celia , Vaina Maria , Valdez Maria , Moran Lucrecia , Ramirez Teresa , Patiño Oscar Ledesma , Riarte Adelina , Gonzalez Nicolas , Fernandes Jayme , Alves Fabiana , Ribeiro Isabela , Garcia-Bournissen Facundo 
Published: May 2023

Background
There is a major need for information on pharmacokinetics (PK) of benznidazole (BNZ) in children with Chagas disease (CD). We conducted a multicentre population PK, safety and efficacy study in children, infants and neonates with CD treated with BNZ (formulated in 100 mg tablets or 12.5 mg dispersible tablets, developed by the pharmaceutical company LAFEPE, in a collaboration with DNDi).

Methods
81 children 0–12 years old were enrolled at 5 pediatric centers in Argentina. Diagnosis of T. cruzi infection was confirmed by direct microscopic examination, or at least two positive conventional serological tests. Subject enrolment was stratified by age: newborns to 2 years (minimum of 10 newborns) and >2–12 years. BNZ 7.5 mg/kg/d was administered in two daily doses for 60 days. Five blood samples per child were obtained at random times within pre-defined time windows at Day 0 at 2–5 h post-dose; during steady state, one sample at Day 7 and at Day 30; and two samples at 12–24 h after final BNZ dose at Day 60. The primary efficacy endpoint was parasitological clearance by qualitative PCR at the end of treatment.

Results
Forty-one (51%) patients were under 2 years of age (including 14 newborns <1 month of age). Median age at enrolment was 22 months (mean: 43.2; interquartile range (IQR) 7–72 months). The median measured BNZ Cmax was 8.32 mg/L (IQR 5.95–11.8; range 1.79–19.38). Median observed BNZ Cmin (trough) concentration was 2 mg/L (IQR 1.25–3.77; range 0.14–7.08). Overall median simulated Css was 6.3 mg/L (IQR 4.7–8.5 mg/L). CL/F increased quickly during the first month of postnatal life and reached adult levels after approximately 10 years of age. Negative qPCR was observed at the end of treatment in all 76 patients who completed the treatment. Five patients discontinued treatment (3 due to AEs and 2 due to lack of compliance).

Conclusion
We observed lower BNZ plasma concentrations in infants and children than those previously reported in adults treated with comparable mg/kg doses. Despite these lower concentrations, pediatric treatment was well tolerated and universally effective, with a high response rate and infrequent, mild AEs.

Trial registration
Registered in clinicaltrials.gov #NCT01549236.
Conservation at Stake: Institutionalized Environmentalisms and Indigenous Knowledges About How to Protect the Brazilian Atlantic Forest
Authors: Thomaz Sandroni Laila 
Published: May 2023

This paper aims to compare two different sets of solutions on best pathways for biodiversity conservation present in a specific territory in the Brazilian Atlantic Forest, in southern Bahia. We look specifically at three interconnected administrative instances: the Tupinambá de Olivença Indigenous Land; the Una Biological Reserve; and the Una Wildlife Refuge. We show that different perspectives regarding what it means to preserve nature come into focus in this territory. These are intertwined with power relations that highlight the inequality in the legitimacy of different groups in decision making for environmental governance. We map the causes and solutions for biodiversity degradation proposed by two contrasting narratives: the Indigenous perspective and the institutionalized western science-based environmentalism developed by state agencies and non-governmental organizations that work with conservation projects in the region. We expect to equalize these contrasting perspectives that are commonly seen in hierarchical terms. We conclude by advocating for managing combinations of diverse sets of knowledge and for pluralism in conservation efforts that accounts for underlying power relations.
Faecal biomarkers of neutrophil and eosinophil origin reflect the response to biological therapy and corticosteroids in patients with IBD
Authors: Lundström Maria Ling , Peterson Christer , Lampinen Maria , Hedin Charlotte R. H. , Keita Åsa V , Kruse Robert , Magnusson Maria K , Lindqvist Carl Mårten , Repsilber Dirk , D’Amato Mauro , Hjortswang Henrik , Strid Hans , Rönnblom Anders ,   BIOIBD consortium, Söderholm Johan D , Öhman Lena , Venge Per , Halfvarson Jonas , Carlson Marie 
Published: May 2023

Abstract

Background:
Faecal calprotectin (FC) is a non-invasive tool for examining response to biologics in inflammatory bowel disease (IBD), but its performance in relation to other novel faecal markers of various cellular origins is unknown.

Methods:
We performed a prospective multicentre cohort study and included patients with active IBD who provided a faecal sample at initiation of biological therapy. Levels of FC, myeloperoxidase (MPO), human neutrophil lipocalin (HNL), and eosinophil-derived neurotoxin (EDN) were analysed and related to clinical remission status at 3 months. Changes in levels of markers at 3 months were calculated and the impact of concomitant use of corticosteroids at baseline was estimated.

Results:
In patients achieving clinical remission (n=27), a decrease in levels of FC (p=0.005), MPO (p<0.001), HNL (p<0.001) and EDN (p<0.001) was observed, whereas no significant decrease was seen in patients not achieving remission (n=39). There was a significant difference in the change in the level of MPO (p=0.01) and HNL (p=0.02) between patients achieving clinical remission compared with those who did not, but changes in FC and EDN could not differentiate between these groups. Patients with concomitant systemic corticosteroids at inclusion had lower levels of HNL (p=0.01) and EDN (p<0.001) at baseline, compared with patients without corticosteroids.

Conclusion:
Faecal MPO, HNL, and EDN are all promising biomarkers for assessing the treatment outcome of biologics in patients with IBD. Faecal levels of EDN and HNL are significantly affected by corticosteroids indicating a greater sensitivity to the effects of corticosteroids compared with FC and MPO.
A family of Apostol–Euler polynomials associated with Bell polynomials
Authors: Khan Nabiullah , Husain Saddam 
Published: May 2023

Abstract
Many authors investigated the characteristics of the Bell, Euler, Bernoulli, and Genocchi polynomials because of their numerous uses in statistics, number theory, and other branches of science. A generating function for mixed-type Apostol–Euler polynomials of order η related with Bell polynomials is presented in this study. We also construct essential identities of Apostol–Euler polynomials of order η connected with Bell polynomials, such as the correlation formula, the implicit summation formula, the derivative formula, some association with Stirling numbers, and specific cases. Also we establish certain symmetric identities and their known consequences. In addition, we investigate several interesting relationships related to umbral calculus.
Some finite integrals involving Mittag-Leffler confluent hypergeometric function
Authors: Pal Ankit 
Published: May 2023

Abstract
In this work, we propose some unified integral formulas for the Mittag-Leffler confluent hypergeometric function (MLCHF), and our findings are assessed in terms of generalized special functions. Additionally, certain unique cases of confluent hypergeometric function have been corollarily presented.
Assessment of essential elements and heavy metals in Saudi Arabian rice samples underwent various processing methods
Authors: Al-Harbi Hanan F. , Al-Mohaimeed Amal M. , El-Tohamy Maha F. 
Published: May 2023

Abstract
Environmental, soil, and groundwater pollution from toxic heavy metals, as well as food safety are all global concerns nowadays. The effect of various processes viz. washing, soaking, and cooking of rice samples (ten rice varieties, 50 samples) on the concentration of essential elements and toxic heavy metals was determined using the inductively coupled plasma-mass spectrometry technique. The concentrations of As, Cd, Cu, and Ni were found to be below the maximum permissible levels. The range of mean concentrations of metals (mg/kg) was recorded as Al (15.495–8.151), Fe (10.358–7.499), Ni (0.399–0.176), Cu (4.518–2.615), Zn (28.635–12.880), As (0.152–0.042), Cd (0.233–0.038), Pb (0.713–0.417), Ti (2.157 > 0.521), Sn (1.406–0.016), and W (1.114–0.017) mg/kg. Pt and Ag metals were not found in all samples. Soaking rice for 2 h was one of the most successful techniques for lowering heavy metal concentrations, followed by overnight soaking, which aided in the elimination of Al, Cd, Pb, and Pb. Heavy metal exposure has a significant impact on human health. This study creates a promising view to use a simple and accurate detection method for minimizing the effect of different processing methods on the essential elements and heavy metal contents.
On the collapsing of Calabi–Yau manifolds and Kähler–Ricci flows
Authors: Li Yang , Tosatti Valentino 
Published: May 2023

Abstract
We study the collapsing of Calabi–Yau metrics and of Kähler–Ricci flows on fiber spaces where the base is smooth.
We identify the collapsed Gromov–Hausdorff limit of the Kähler–Ricci flow when the divisorial part of the discriminant locus has simple normal crossings.
In either setting, we also obtain an explicit bound for the real codimension-2 Hausdorff measure of the Cheeger–Colding singular set and identify a sufficient condition from birational geometry to understand the metric behavior of the limiting metric on the base.
Constraint-based bare-hand immersive 3D modelling
Authors: Jung Thomas , Israel Johann Habakuk , Ahlhelm Ruben , Bauer Patrick 
Published: May 2023

AbstractThree-dimensional user interfaces that are controlled by the user’s bare hands are mostly based on purely gesture-based interaction techniques. However, these interfaces are often slow and error prone. Especially in the field of immersive 3D modelling, gestures are unsuitable because they complicate and delay the modelling process. To address these problems, we present a new gesture-free 3D modelling technique called “3D touch-and-drag”, which allows users to select vertices by approaching them and to terminate operations by moving the 3D cursor (e.g. the forefinger) away from the constraint geometry (e.g. a straight line or a plane). Our proposed technique makes it possible to transfer the existing 3D modelling concepts (“3D widgets”) to virtual environments, as shown by an experimental 3D modelling tool. The gesture-free bare-hand interaction also improves the possibility of tactile feedback during 3D manipulation. We compared different modelling techniques for controlling the 3D widgets. We found that controller-based techniques are significantly faster than finger-tracking-based techniques. The 3D touch-and-drag technique is about as fast as gesture-based interactions. Mouse interaction in a two-dimensional GUI is only slightly faster than the 3D modelling techniques. Since our proposed technique has proven to be at least equivalent to gesture-based interaction techniques in terms of accuracy and efficiency, its further development using more accurate tracking techniques seems promising to exploit the advantages of hands-free and gesture-free interaction for immersive 3D modelling.
Synthesis and crystal structure of an ionic phenyltin(iv) complex of N-salicylidene-valine
Authors: Böhme Uwe , Weling Gisela 
Published: May 2023

Abstract
Triethylammonium dichloro[N-[(2-oxyphenyl)methylidene]valinato]-phenyl-tin(iv) was prepared and characterized by spectroscopic methods and single crystal X-ray crystallography. The compound consists of a triethylammonium cation and a tin complex as anion. The tin complex is composed of a tridentate O,N,O-Schiff base ligand coordinated to a SnCl2Ph unit. The tin atom is in distorted octahedral coordination geometry. NMR spectroscopic studies have shown that the unusual hexa-coordinated tin complex was formed as a kinetically controlled product. Storage of the solid product for several years led to a transformation into a thermodynamically stable penta-coordinated tin complex.
The crystal structure of (E)-N
′-(2-bromobenzylidene)-2-naphthohydrazide, C36H26Br2N4O2
Authors: Yuan Lin , Deng Shao-Wen , Liu Fang , Li Zhong-Yan 
Published: May 2023

Abstract
C36H26Br2N4O2, triclinic, P1 (no. 1), a = 8.700(5) Å, b = 9.188(5) Å, c = 9.722(6) Å, α = 91.610(6)°, β = 91.436(6)°, γ = 100.925(6)°, V = 762.4(8) Å3, Z = 1,

R

g
t

${R}_{\mathrm{g}\mathrm{t}}$

(F) = 0.0381,

w

R

r
e
f

$w{R}_{\mathrm{r}\mathrm{e}\mathrm{f}}$

(F
2) = 0.1016, T = 296(2) K.
Symbolic Theology and Resistance in the Theology of Martin Luther King, Jr. and Paul Tillich
Authors: Birkler Margrethe Kamille 
Published: May 2023

Abstract
In this article, I study how symbolic theology can be advantageously utilized in the resistance against oppressing structures and ideologies. Studying two sermons of Paul Tillich and two speeches of Martin Luther King, Jr. and the symbols used herein as a call to resistance against injustice, I wish to show how theologically grounded symbols have been used to resist injustice and in the call for justice. Furthermore, I study how the symbols used by Tillich and King can be utilized and reinterpreted in the various struggles taking place today against old and new oppressing structures and ideologies. The resistance against injustice must, however, also be undertaken intersectionally. And finally, I propose to bring the understanding of theology as symbolic engagement from Robert C. Neville into conversation with intersectional symbolic theology. I believe an intersectional symbolic theology can be successfully applied to feminist theology, queer theology, and other liberative theologies today.
Effect of bis(methylimidazolium) ionic liquid on the extraction of actinides and lanthanides with bis(carbamoylmethylphosphine oxide) extractant from nitric acid solutions
Authors: Turanov Alexander N. , Karandashev Vasilii К. , Sharova Elena V. , Аrtyushin Оleg I. , Kostikova Galina V. , Fedoseev Alexander M. 
Published: May 2023

Abstract
A novel bis(methylimidazolium) ionic liquid 3,3′-(pentane-1,5-diyl) bis(1-methylimidazolium) bis(trifluoromethanesulfonul)imide [C5(mim)2][Tf2N]2 has been synthesized. Its effect on the extraction of U(VI), Th(IV), Am(III), and lanthanides(III) from nitric acid solutions with a polydentate neutral bis(carbamoylmethylphosphine oxide) ligand L containing two bidentate fragments Ph2P(O)CH2C(O)NH–, interconnected by 4,7,10-trioxatridecane spacer through amide nitrogen atoms has been investigated. The efficiency of the extraction of metal ions with solutions of L in 1,2-dichloroethane (DCE) significantly increases in the presence of [C5(mim)2][Tf2N]2. A synergistic effect in the extraction of metal ions in this system has been explained with the high hydrophobicity of the Tf2N− anions, which are involved in the formation of extracted complexes as counterions. The value of the synergistic effect decreases with increasing acidity of the aqueous phase. The influence of the composition of the aqueous and organic phases on the efficiency of the extraction of metal ions into the organic phase is considered, and the stoichiometry of the extracted complexes is determined. The effect of the HTf2N coextraction with L on the extraction of metal ions in the L – [C5(mim)2][Tf2N]2 system is discussed. The synergistic effect in the extraction of Ln(III) from 3 M HNO3 solutions with the mixture of L and [C5(mim)2][Tf2N]2 in DCE is higher than that in the L – [C4mim][Tf2N] – DCE system.