bluuebunny/crossref_metadata_2025_split huggingface dataset:
The SNP rs460089 in the gene promoter of the drug transporter OCTN1 has prognostic value on treatment-free remission in chronic myeloid leukemia patients treated with imatinib
Authors: Polakova Katerina Machova , Albeer Ali , Polivkova Vaclava , Krutska Monika , Vlcanova Katerina , FABARIUS Alice , Klamova Hana , Spieß B , Waller Cornelius , Bruemmendorf Tim , Dengler Jolanta , Kunzmann Volker , Burchert Andreas , Belohlavkova Petra , Mustjoki Satu , Faber Edgar , Mayer Jiri , Zackova Daniela , Panayiotidis Panayiotis , Richter Johan , Hjorth-Hansen Henrik , Płonka Magdalena , Szczepanek Elżbieta , Szarejko Monika , Bober Grażyna , Hus Iwona , Grzybowska-Izydorczyk Olga , Kloczko Janusz , Paczkowska Edyta , Niesiobędzka-Krężel Joanna , Giannopoulos Krzysztof , Mahon Francois-Xavier , Sacha Tomasz , Saussele Susanne , Pfirrmann Markus 
Published: April 2023

Abstract
Membrane transporters are important determinants of drug bioavailability. Their expression and activity affect the intracellular drug concentration in leukemic cells impacting response to therapy. Pharmacogenomics represents genetic markers that reflect allele arrangement of genes encoding drug transporters associated with treatment response. In previous work, we identified SNP rs460089 located in the promotor of SLC22A4 gene encoding imatinib transporter OCTN1 as influential on response of patients with chronic myeloid leukemia treated with imatinib. Patients with rs460089-GC pharmacogenotype had significantly superior response to first-line imatinib treatment compared to patients with rs460089-GG. This study investigated whether pharmacogenotypes of rs460089 are associated with sustainability of treatment-free remission (TFR) in patients from the EUROpean Stop Kinase Inhibitor (EURO-SKI) trial. In the learning sample, 176 patients showed a significantly higher 6-month probability of molecular relapse free survival (MRFS) in patients with GC genotype (73%, 95% CI: 60–82%) compared to patients with GG (51%, 95% CI: 41–61%). Also over time, patients with GC genotype had significantly higher MRFS probabilities compared with patients with GG (HR: 0.474, 95% CI: 0.280–0.802, p = 0.0054). Both results were validated with data on 93 patients from the Polish STOP imatinib study. The SNP rs460089 was found as an independent predictor of TFR.
Wear-corrosion characterization of electrodeposited NiW alloys in artificial see water
Authors: Santos C. B. dos , Kölle S. 
Published: April 2023

AbstractDue to their mechanical and chemical properties, NiW alloys present a very promising alternative in various applications, with the advantage of using elements that do not have a high environmental hazard. NiW alloys were analyzed with regard to their dry wear and wear-corrosion resistance in a saline environment. The analyzed alloys were obtained free of cracks, thus avoiding a reduction of the corrosion resistance of the samples due to the presence of defects produced by the electrodeposition process. The wear behaviour of NiW alloys was investigated using a ball-on-plate tribometer under normal load and reciprocating linear sliding. Comparative measurements in dry and wet conditions were performed to identify the influence of the tribocorrosive conditions on the wear-corrosion resistance of the alloys. The results obtained show that for layers with higher thicknesses, the material lost in condition of wear-corrosion is at the same level or even lower than in dry wear.
Impacts of potential anticancer agents based on Pillar[5]arene for head and neck squamous cell carcinoma cells
Authors: Kuccukturk Serkan , Karaselek Mehmet Ali , Duran Tugce , Kursunlu Ahmed Nuri , Ozmen Mustafa 
Published: April 2023

Abstract
This study was conducted to investigate impacts of potential anticancer (associated with apoptosis and caspase pathways) of two newly synthesized derivatives of pillar[5]arene, named as d-Q-P5 and p-Q-P5, on Squamous cell carcinomas of the head and neck (HNSCC) cells. The MTT method was used to determine the IC50 doses of the derivatives on HNSCC cells, and the changes in gene expression were analyzed by real-time polymerase chain reaction (qPCR). The apoptosis change was confirmed by flow cytometry analysis. The results showed that the d-Q-P5 and p-Q-P5 effectively inhibited the proliferation of the cells by upregulating proapoptotic genes (Bax, Bad, p53, Bak, and Apaf-1) and genes involved in the caspase pathway (Casp2, Casp3, and Casp9), while downregulating the antiapoptotic gene (Bcl-2). This study is the first to demonstrate the potential anticancer effects of these two agents on HNSCC cells by positively regulating apoptosis gene expression.
Sulforaphane reduces adipose tissue fibrosis via promoting M2 macrophages polarization in HFD fed-mice
Authors: Song Tianzeng , Zhang Zhenzhen , Chen Huali , Pan Cheng , Li Rui , Zhao Wangsheng 
Published: April 2023

AbstractBackground/Objectives:Adipose tissue fibrosis has been identified as a novel contributor to the pathomechanism of obesity associated metabolic disorders. Sulforaphane (SFN) has been shown to have an anti-obesity effect. However, the impact of SFN on adipose tissue fibrosis is still not well understood.Methods:In this study, obese mice induced by high-fat diets (HFD) were used, and SFN was administered through subcutaneous injection to examined the effects on adipose tissue fibrosis. Analysis included quantification of: (i) body weight, food intake, fat mass, glucose tolerance and insulin tolerance; (ii) the relative mRNA and protein levels of fibrosis, inflammation and macrophages polarization related genes; (iii) tissue histology using Hematoxylin-Eosin (H&E), immunohistochemistry and immunofluorescent staining; and (iv) the levels of inflammatory cytokinesin serum.Results:According to the current findings, SFN dramatically enhanced glucose tolerance and decreased body weight in diet-induced-obesity (DIO) mice. Additionally, SFN therapy significantly reduced extracellular matrix (ECM) deposition and altered the expression of genes related to fibrosis. Furthermore, SFN also reduced inflammation and promoted macrophages polarization towards to M2 phenotype in adipose tissue, which protected adipose tissue from fibrosis. Notably, SFN-mediated nuclear factor E2-related factor 2 (Nrf2) activation was crucial in decreasing adipose tissue fibrosis.Conclusions:These results implied that SFN had favorable benefits in the management of adipose tissue fibrosis, which consequently ameliorates obesity-related metabolic problems. Our research provides new treatment strategies for obesity.
Improved Reputation Evaluation for Reliable Federated Learning on Blockchain
Authors: Sui Jiacheng , Li Yi , Huang Hai , Fang Li 
Published: April 2023

Abstract
Worker selection is critical to the success of federated learning, but issues such as inadequate incentives and poor-quality data can negatively impact the process. Existing studies have used the multi-weight subjective logic model, but it is vulnerable to malicious evaluation and unfair to newly added nodes. In this paper, we propose an improved reputation evaluation algorithm that allows evaluations from different sources to influence each other and reduce the impact of malicious comments. Our approach effectively distinguishes between malicious and honest users and improves worker selection and collaboration in federated learning.
Hybrid modeling techniques for 3D printed DIEP Flap models
Authors: Jacobson Nicholas M. , Carerra Erik , Treat Aaron , McDonnell Megan , Mathes David , Kaoutzanis Christodoulous 
Published: April 2023

Abstract
Deep Inferior Epigastric Perforator Flap (DIEP) surgical procedures have benefited in recent years from the introduction of 3D printed models, yet new technologies are expanding design opportunities which promise to improve patient specific care. Numerous studies, utilizing 3D printed models for DIEP, have shown a reduction of surgical time and complications when used in addition to the review of standard CT imaging. Now, with new technology, highly detailed multi-material 3D printed models are allowing more of the information from medical imaging to be expressed in 3D printed models. This additional data, coupled with advanced digital modeling tools harnessing both voxel- and mesh-based modeling environments, is allowing for an expanded library of modeling techniques which create a wealth of concepts surgeons can use to assemble a presurgical planning model tailored to their particular setting, equipment, and needs. A DIEP free flap procedure requires locating the inferior epigastric perforator vessels traversing and perforating the rectus abdominis muscle, perfusing the abdominal skin and fatty tissue. The goal of dissecting the inferior epigastric perforator vessels is complicated by the opacity of the fatty tissue and muscle. Previous attempts to 3D print patient specific models for DIEP free flap cases from CT imaging has shown a wide range of designs which only show variations of perforator arteries, fatty tissue, and the abdominis rectus muscle. A limitation of digital surface-based modeling tools has led to existing models lacking the ability to composite critical anatomical features, such as differentiation of vessels through different tissues, coherently into one model, providing information more akin to the surgical challenge. To remedy this limitation, we have leveraged a voxel-based modeling environment to composite complex modeling elements and incorporate a ruled grid upon the muscle providing effortless ‘booleaning’ and measured guidance.
The impact of vascular volume fraction and compressibility of the interstitial matrix on vascularised poroelastic tissues
Authors: Mascheroni Pietro , Penta Raimondo , Merodio José 
Published: April 2023

Abstract
In this work we address the role of the microstructural properties of a vascularised poroelastic material, characterised by the coupling between a poroelastic matrix and a viscous fluid vessels network, on its overall response in terms of pressures, velocities and stress maps. We embrace the recently developed model [1] as a theoretical starting point and present the results obtained by solving the full interplay between the microscale, represented by the intervessels’ distance, and the macroscale, representing the size of the overall tissue. We encode the influence of the vessels’ density and the poroelastic matrix compressibility in the poroe-lastic coefficients of the model, which are obtained by solving appropriate periodic cell problem at the microscale. The double poroelastic model [1] is then solved at the macroscale in the context of vascular tumours, for different values of vesssels’ walls permeability. The results clearly indicate that improving the compressibility of the matrix and decreasing the vessels’ density enhances the transvascular pressure difference and hence transport of fluid and drug within a tumour mass after a transient time. Our results suggest to combine vessel and interstitial normalization in tumors to allow for better drug delivery into the lesions.
Nondefinability results with entire functions of finite order in polynomially bounded o-minimal structures
Authors: Sfouli Hassan 
Published: April 2023

Abstract
Let R be a polynomially bounded o-minimal expansion of the realfield. Let f(z) be a transcendental entire function of finite order ρ and type σ∈[0, ∞]. The main purpose of this paper is to show that if (ρ<1) or (ρ=1 and σ=0), the restriction of f(z) on the real axis is not definable in R. Furthermore, we give a generalization of this result for any ρ∈[0,∞).
Classification of Lung Cancer with Deep Learning Res-U-Net and Molecular Imaging
Authors: Malligeswari N. , Kavya G. 
Published: April 2023

Abstract
Lung cancer is the prevalent malignancy, despite the great breakthroughs in detection and prevention and it remains the important cause of death. In recent days, artificial intelligence has exploded in all fields of science. The use of artificial intelligence in medical science has improved in accuracy and precision of predicting this infestation in the initial stages. In the proposed study a deep learning and molecular imaging is used for classifying two different types of lung cancer. The PET/CT (positron emission tomography/computed tomography) employing an injection 18F-FDG has developed as a useful tool in therapeutic oncologic imaging for both metabolic and anatomic analysis. The proposed model uses Res-U-Net to classify small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) from normal by using 18F-FDG PET/CT images from the radiogenmics dataset. This datasets are pre-processed by Gaussian smoothing to reduce the noise from the PET/CT images. Finally, the classification result is obtained through the support vector machine (SVM) classifier which proves the efficiency of the proposed technique. The outcome of the proposed technique yields best and accurate results and it yields the classification accuracy rate of 96.45%for lung cancer into NSCLC and SCLC.
Predicting return to work after head and neck cancer treatment is challenging due to factors that affect work ability
Authors: Ehrsson Ylva Tiblom , Kisiel Marta A. , Yang Yukai , Laurell Göran 
Published: April 2023

Abstract
Purpose To prospectively investigate the factors that hinder and facilitate return to work (RTW) at 3 and 12 months after the end of treatment in head and neck cancer (HNC) survivors and whether these factors influence the ability to continue working after treatment.
Methods Participants (n=227) aged ≤65 years at diagnosis with HNC were included. Data were collected before the start of treatment and 3 and 12 months after the end of treatment. The Rubin causal model was used for statistical analysis.
Results Within the 3-month follow-up period, 92 participants had RTW and 30 had retired. At the 12-month follow-up, 80 of these participants were still working, another 51 participants had RTW, and five patients working still suffered from cancer. The hindrances to RTW within 3 months were advanced tumour stage (III and IV) (p=0.0159) and multi-modality treatment (p=0.0366). Hindrance to RTW at the 12-month follow-up was oral cancer (p=0.0194), and the facilitator was a white collar job (p=0.0411). Participants living with a spouse or partner had an earlier RTW (p=0.0414).
Conclusions A high rate of early RTW was identified, with only 13% dropping out of work in one year. Disease and treatment factors were the most important hindrances to RTW, and type of work and living with a spouse or partner were nonclinical factors influencing RTW.
Implications for Cancer Survivors: More research is needed to understand the impact of cancer rehabilitation to facilitate RTW and the economic burden of being on sick leave.
Asymptotic expansions for a class of generalized holomorphic Eisenstein series, Ramanujan's formula for ζ(2k + 1), Weierstrass' elliptic and allied functions
Authors: Katsurada Masanori , Noda Takumi 
Published: April 2023

Abstract

For a class of generalized holomorphic Eisenstein series, we establish complete asymptotic expansions (Theorems 1 and 2), which together with the explicit expression of the latter remainder (Theorem 3), naturally transfer to several new variants of the celebrated formulae of Euler and of Ramanujan for specific values of the Riemann zeta-function (Theorem 4 and Corollaries 4.1–4.5), and to various modular type relations for the classical Eisenstein series of any even integer weight (Corollary 4.6) as well as for Weierstraß’ elliptic and allied functions (Corollaries 4.7–4.9). Crucial rˆoles in the proofs are played by certain Mellin-Barnes type integrals, which are manipulated with several properties of confluent hypergeometric functions.
2020 Mathematics Subject Classification. Primary 11M36; Secondary 11E45, 11M35, 11F11.
Investigation of heavy metal analysis on medicinal plants used for the treatment of skin cancer by traditional practitioners in Pretoria
Authors: Oluwaseun Mary Oladeji , Kopaopa Boikanyo Genneyrolter , Mugivhisa Liziwe Lizbelth , Olowoyo Joshua Oluwole 
Published: April 2023

Abstract
The use of medicinal plants for the treatment of diseases, including cancer, is acknowledged and accepted in many African nations. Heavy metal contamination of plant materials poses a potential health risk, particularly for populations that are already vulnerable. This study determine the levels of heavy metals in medicinal plant samples used for treatment of skin cancer and evaluate the health risk caused by heavy metals to the adult population in Pretoria, South Africa using inductively coupled plasma mass spectrometry (ICP-MS). The concentrations of metals were as follows; As (< 0.2–1.04 ± 0.026), Cd (0.02 ± 0.00026–0.167 ± 0.006), Pb (0.38 ± 0.01–2.27 ± 0.05), Cr (5.31 ± 0.21– 26.9 ± 3.96) mg/kg and Hg which were lesser than 0.02 mg/kg. The mean concentrations of all analyzed heavy metals are above permissible limit except for Hg which are lower than the permissible limit. The Hazard Quotient (THQ) was less than 1 for all the heavy metals, suggesting that there is no obvious non-carcinogenic health risks associated with the consumption of these medicinal plants for now even though the prolonged use may result in health risks. The ingestion route was identified as the primary contributor to the overall risk by the health index (HI) values in the present study were more than 1, indicating that the combined effects of the heavy metal contaminants present in a particular herbal preparation pose health risk in the long term. Our findings support the need for close monitoring of potential heavy metals concentrations in medicinal plants given to patients from herbal shops.
Constructing invariants of Weil representations associated with finite quadratic modules of square-free level
Authors: Xiong Ran 
Published: April 2023

Abstract
Constructing invariants of Weil representations associated with finite quadratic modules is basic and important in the topic of modular forms. In this article we construct a family of invariants of Weil representations associated with square-free level quadratic modules by computing the shadow of nonholomorphic Eisenstein series of vector-valued modular forms of weight two explicitly. Furthermore we prove that, for any finite quadratic module whose cardinality is a square of an odd prime p-power and the 𝔽p-dimension is more than five, the space of invariants of Weil representation associated with this finite quadratic module must contain nonzero elements.
Mathematics Subject Classification (2020) 11F27, 11F30.
Andarine Plays a Robust In-vitro Anti-carcinogenic Role on A549 Cells Through Inhibition of Proliferation and Migration, and Activation of Cell-cycle Arrest, Senescence, and Apoptosis
Authors: Demircan Turan , Yavuz Mervenur , Bölük Aydın 
Published: April 2023

Abstract
Lung cancer is a highly aggressive malignancy with limited therapeutic options and a poor prognosis. Due to the development of resistance to chemotherapeutic drugs, novel therapeutic agents are required. Androgen receptor (AR) signaling affects various genes contributing to cancer characteristics, including cell cycle progression, proliferation, angiogenesis, and metastasis. The misregulation of AR signaling has been observed in many cancers, including lung cancer. Therefore, inhibiting AR signaling using anti-androgens, AR inhibitors, or AR-degrading molecules is a promising strategy for treating lung cancer. Selective androgen receptor modulators (SARMs) are small molecule drugs with a high affinity for the androgen receptor. Commonly used cell culture techniques (MTT assay, colony-formation assay, soft-agar assay, wound healing assay, EdU staining, Annexin-V/PI staining) were employed to investigate the potential anti-carcinogenic effect of andarine on A549 cells. The expression levels of several genes involved in the cell cycle and apoptosis processes were determined by qPCR. Our findings demonstrate that andarine inhibited growth, migration, and proliferation while inducing apoptosis in lung cancer cells. Gene expression analysis revealed that andarine significantly upregulated the expression of BAX, CDKN1A, PUMA, and GADD45A while downregulating MKI67, BIRC5, and PCNA expression. Although there is no study on the utility of SARMs as inhibitors of lung cancer, we report the first study evaluating the potential anti-carcinogenic effects of andarine, a member of the SARMs, on lung cancer. Our results suggest that andarine could be considered as a promising drug candidate to test further for lung cancer treatment.
Fabrication and Investigation of Electrospun Poly caprolactone /Gelatin/Egg white Nanofibers for Skin Tissue Engineering
Authors: Afrashi Mehran , Semnani Dariush , Hashemibeni Batool , Shokrgozar Mohammad Ali 
Published: April 2023

Abstract
Nowadays, the use of green materials has been expanded for biomedical and bioengineering. Egg white (EW) is a low-cost and abundant candidate for various biomedical applications. In this study, a nanofibrous scaffold based on EW blended with polycaprolactone/gelatin (PCL/Gel) was fabricated using electrospinning. The fabricated samples were characterized using Physicochemical analyses including SEM, FT-IR spectroscopy, tensile assay, and contact angle measurement. The optimized samples were used as scaffolds for cell culture. The average diameter of prepared nanofibers measured 215.9 nm to 434.1 nm. The FT-IR and DSC assays showed the physical blending of EW with PCL/Gel was appropriate and there wasn’t a new chemical reaction between them. The contact angle test indicated the hydrophilicity of the scaffolds was decreased from 26.25º to 116.5º by increasing the EW amount in the PCL/Gel (0%-15%). Furthermore, the electrospun PCL/Gel nanofibrous mat with 10% EW exhibited better bioactivity than other samples with different amounts of EW. Therefore, adding 10% of EW to PCL/Gel nanofibers can improve the efficiency of fibroblast culture. This research introduced a nanofibrous scaffold for skin tissue engineering containing Gel and EW as low-cost and available materials that can be used for biological applications and also for productions like engineered leathers.