bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using of supersaturated oxygen delivery (SSO2 therapy) in patients with acute myocardial ischemia
Authors: Radovskiy A. M. , Bautin A. E. , Yakovlev A. N. , Shlyakhto E. V. 
Published: June 2023

Oxygen is the main participant in redox reactions in the body and its deficiency can lead to organ dysfunction. Thus, a decrease in blood flow in a certain region of the myocardium in patients with coronary heart disease can cause a heart attack. According to experimental studies, early reperfusion reduces infarct size, and clinical studies have shown that early effective reperfusion of the affected artery and prevention of re-occlusion is the basis for minimizing infarct size and mortality.Timely performed percutaneous intervention in patients with acute myocardial infarction significantly reduced the mortality rate and the risk of heart failure. Despite the endovascular treatment effectiveness, there is still a need for additional methods of cardioprotection, reducing the area of myocardial infarction and preventing the development of heart failure and adverse left ventricular remodeling. Blood oxygen supersaturation (SSO2 therapy) is one of the adjuvant methods of cardioprotection in the treatment of patients with acute myocardial ischemia.This review describes possible mechanisms for implementing the cardioprotective effects of SSO2 therapy, technology and equipment necessary for the application of this technique. In addition, the results of experimental and clinical studies on SSO2 therapy are consecrated. Of note, only one multicentre prospective randomized controlled trial with uniform randomization was performed. Thus, the use of this technology is limited by the use a commercial equipment.
État des lieux de l’utilisation des énergies de cuisson dans les ménages de Kinshasa : analyse de la substitution du bois-énergie
Authors: BELANI MASAMBA Justin , MPANZU BALOMBA Patience , NGONDE NSAKALA Hervé , KINKELA SAVY Charles 
Published: June 2023

En République démocratique du Congo, l’étude fait l’état des lieux de l’utilisation des énergies de cuisson par les ménages de Kinshasa et détermine le modèle énergétique de cette ville. Elle constitue une contribution à la réflexion sur la substitution du bois-énergie comme principale énergie de cuisson par des énergies propres. Le bois-énergie constitue un des moteurs de la déforestation et de la dégradation des forêts du Bassin du Congo. Une enquête quantitative a été menée auprès d’un échantillon de 1 154 ménages tirés aléatoirement dans la ville de Kinshasa. Ces ménages ont été subdivisés en trois classes de revenu : bas, moyen et élevé. Il ressort des résultats de l’étude que les ménages de Kinshasa utilisent six énergies pour la cuisson des aliments à des proportions différentes. Il s’agit de la sciure de bois (2,6 %), du bois de chauffe (14 %), du charbon de bois (95 %), du pétrole lampant (12 %), de l’électricité (60 %) et du gaz de pétrole liquéfié (4 %). Le rapprochement fait des données recueillies au modèle d’échelle énergétique, modèle qui indique que le ménage passe à des énergies de niveau supérieur à mesure que son revenu s'améliore, n’a pas permis de valider ledit modèle, car les ménages à niveau de revenu moyen n’utilisent pas plus que les autres classes les énergies de transition (charbon de bois et pétrole). De même, le rapprochement des données au modèle d’empilement d’énergies, modèle qui stipule que quand le revenu augmente le ménage a tendance à accroître le nombre d’énergies utilisées sans pour autant abandonner les anciennes, n’a pas permis de valider ce modèle étant donné que seuls les ménages à niveau de revenu élevé empilent davantage les énergies. La politique de réduction de l’utilisation du bois-énergie devrait être basée sur l’amélioration de la desserte en électricité ainsi que la promotion de l’utilisation du GPL.
PENGARUH VARIASI MEDIA TANAM TERHADAP PERTUMBUHAN KAYU PUTIH (Melaleuca leucadendron)
Authors: Jannah Raudatul , Nugroho Yusanto , Susilawati Susilawati 
Published: June 2023

Eucalyptus in Kalimantan is mostly used as a plant for revegetation and post-mining land reclamation because eucalyptus has a high adaptability to various environmental conditions. This study aimed to analyze the growth of eucalyptus seedlings on various seedling media (peat soil, red yellow podzolic (PMK) and PMK mixed with rice husks in a ratio of 5:1) and to analyze the growth response of eucalyptus seedlings to the application of NPK fertilizer. The method used in this study was a randomized block design with children as samples, with 3 treatments and 3 groups with 6 samples for each treatment and a completely randomized design. The results showed that the highest percentage of eucalyptus plant life in PMK growing media was 99.9%. The highest height growth in PMK+husk growing media was 23.68 cm and the highest number of leaves added to PMK growing media was 35 strands. The percentage of live eucalyptus seedlings treated with growth enhancement treatment with NPK fertilizer for peat growing media was 42.67% and PMK + husk was 98%. The results of the analysis using the ANOVA test showed that NPK fertilization had no effect on the addition of height on both planting media and the number of leaves on peat media, but had a significant effect on PMK+husk growing media.Kayu putih di Kalimantan lebih banyak digunakan sebagai tanaman revegetasi dan reklamasi lahan pascatambang karena kayu putih dapat beradaptasi dengan baik pada kondisi lingkungan yang beragam. Penelitian ini bertujuan untuk menganalisis pertumbuhan semai kayu putih pada berbagai media semai (tanah gambut, podsolik merah kuning (PMK) dan PMK yang dicampur sekam padi dengan perbandingan 5:1) dan menganalisis respon pertumbuhan semai kayu putih terhadap pemberian pupuk NPK. Metode yang digunakan dalam penelitian ini adalah rancangan acak kelompok dengan anak contoh, dengan 3 perlakuan dan 3 kelompok dengan 6 anak contoh untuk setiap perlakuan dan rancangan acak lengkap. Hasil penelitian menunjukkan bahwa kayu putih pada media tanam PMK memiliki persentase hidup tertinggi yaitu 99,9%. Pertumbuhan tinggi tertinggi pada media tanam PMK+sekam yaitu 23,68 cm dan penambahan jumlah daun tertinggi pada media tanam PMK yaitu 35 helai. Persentase hidup semai kayu putih yang diberikan perlakuan peningkatan pertumbuhan dengan pemberian pupuk NPK untuk media tanam gambut sebesar 42,67% dan PMK+sekam sebesar 98%. Hasil analisis menggunakan uji anova menunjukan bahwa pemupukan NPK tidak berpengaruh terhadap penambahan tinggi pada kedua media tanam dan jumlah daun pada media gambut, namun berpengaruh nyata pada media tanam PMK+sekam.
ACTIVITIES OF KHARKIV POLYTECHNICAL INSTITUTE DURING THE GERMAN OCCUPATION
Authors: Zhurilo Dmitry Yurievich , Larin Аndrew Alekseevych 
Published: June 2023

The article examines the activities of employees of the Kharkiv Polytechnic Institute who remained in Kharkiv during the nazi occupation during the Great Patriotic War. These employees were unable to leave the city on time due to the poor organization of the evacuation of the institute. Difficult circumstances forced many of them to cooperate with the occupiers. However, this cooperation did not give much to the invaders, but it helped most of the scientists of the Kharkiv Polytechnic Institute to survive and preserve the buildings of the institute, library collections and laboratory equipment. The names of outstanding scientists and teachers who were in the occupation are given. The horrors of the new government are shown: hunger, cold, the death of civilians. Most of the teachers and staff of the Kharkiv Polytechnic Institute were forced to exchange their own things, jewelry, and building materials for food. The facts of violation of international law by German troops are given. It is shown that the German authorities promoted small-scale handicrafts, retail trade, and the provision of household services. However, the main goal of the German troops was to provide the German army with food, equipment, transport, housing, as well as sending young people and the able-bodied population to forced labor in Germany. The German press was engaged in disinformation, spreading false assurances about the happy life of Eastern workers in Germany, about introducing them to European culture, about their rest and leisure. It is described that thanks to the activities of an outstanding chemist, Professor Pavel Didusenko, it was possible to establish the production of matches and soap. Thanks to the implementation of these essential necessities, scarce in wartime, it was possible to save the lives of a large number of employees of the Kharkiv Polytechnic Institute.
The More Things Change, the More They Stay the Same
Authors: Jarvis-Selinger Sandra , Armstrong April , Wisener Katherine 
Published: June 2023

Introduction:
Despite increasing emphasis on the development and implementation of Residents-as-Teachers programs, resident perspectives on their roles as teachers have rarely been explored. This paper explores trends across 7 years of data collected from resident leaders across North American orthopaedic residency programs.

Methods:
Data were collected during the American Orthopaedic Association's resident-only engagement activity known as the C. McCollister Evarts Resident Leadership Forum (RLF). A total of 997 of 1,050 RLF participants responded from 2015 to 2021.

Results:
Residents perceived themselves as having a strong influence on medical students’ education more so than any other teacher. However, less than one third are provided with any formal instruction from their institutions to support their teaching, and nearly 3 quarters of participants felt there was room for improvement in their teaching effectiveness. For the most part, resident perspectives have stayed relatively consistent over time.

Discussion:
Residents are keen and willing to invest time into developing their teaching effectiveness. There may be a need for improved advocacy to program directors to increase the presence and availability of formal Residents-as-Teachers programs to support residents in their roles as teachers. We offer suggestions for the composition of such programs for consideration.
Optimised diets for improving human, animal, and environmental health in the Rhine-Ruhr Metropolis in Germany
Authors: Escobar Neus , Falkenberg Timo , Gupta Shivam , Heinzel Christine , Junior Eliseu Verly , Jolliet Olivier , Borgemeister Christian , Nöthlings Ute , Paris Juliana Minetto Gellert 
Published: June 2023

Abstract
Dietary shifts are needed to align the global food systems with the planetary boundaries and contribute to Sustainable Development Goals. We employed a Life Cycle Assessment framework, extended with indicators reflecting the One Health approach, to assess 2020 food consumption data collected through a survey in the Rhine-Ruhr Metropolis (Germany). Feasible optimisation scenarios representing more sustainable food choices were explored, inducing improvements across human, animal and environmental health. Meat and meat products contributed most to overall environmental impacts and fish and seafood, to animal welfare loss. Sodium intake was the most contributing risk factor for life minutes lost. Reducing 55% of greenhouse gas emissions and improving human health indicators by 25% is possible with a shift towards flexitarian and vegetarian dietary scenarios. These optimisations deliver improvements across One Health dimensions with marginal changes in dietary scenarios and align with the sustainability goals of the EU Green Deal.
Covid-19 infection in pediatric cases and their clinical feature in Southwestern Iran: A cross-sectional, multi-center study
Authors: Jamalidoust Marzieh , Jalil Mohsen , Ashkan Zahra , Sharifi Moslem , Hemmati Rouhollah , Dashti Anahita Sanaei , Kadivar Mohammad Rahim , Pouladfar Gholamreza , Amanati Ali , Hamzavi Sedigheh , Asaie Sadaf , Eskandari Maryam , Aliabadi Nasrin , Ziyaeyan Mazyar 
Published: June 2023

Abstract
With the SARS-CoV-2 pandemic, the impact of recent coronavirus, especially in children, cannot be ignored. In this study, we evaluated the SARS-CoV-2 infection rates and associated features in children less than 18 years of age in Fars and "Kohgiluyeh and Boyer Ahmad", provinces, Iran. 5943 children who suspected SARS-CoV-2 infection were enrolled in this study. Demographic and clinical data on pediatric SARS-CoV-2 infections were collected from 16 February 2020 to 20 June 2021. Underlying conditions were considered in this study as well. As revealed, among 5943 patients suspected to Covid-19 infections, 13.51% were confirmed by rt-PCR assay. The female/male ratio was 1:1.3 with a mean age of 5.71 years old and 11.2% of positive patients were transferred to the PICU. Covid-19 was significantly higher in malignant and diabetic children rather than those with other underlying diseases. Children of all ages seem to be susceptible to Covid-19, and there is no significant difference between both sexes. Most of the Covid-19 cases are related to the 10–18 age group, which is because more interact with the community of this group. Among a number of children with different underlying diseases, children with cancer had the highest risk of SARS-CoV-2 infection, followed by those with diabetes.
Postoperative recurrence factors in patients with pT3N0M0 clear cell renal cell carcinoma, called M0 intermediate-high-risk group of the KEYNOTE 564 trial
Authors: Naito Hirohito , Okazoe Homare , Ishikawa Ryou , Honda Tomoko , Osaki Yu , Abe Yohei , Tohi Yoichiro , Matsuoka Yuki , Kato Takuma , Taoka Rikiya , Ueda Nobufumi , Haba Reiji , Sugimoto Mikio 
Published: June 2023

Abstract
Background
KEYNOTE 564, a phase 3 trial, demonstrated the efficacy of pembrolizumab as an adjuvant therapy for clear cell renal cell carcinoma; however, it remains unclear which patients in the M0 intermediate-high-risk group of the trial who were pT3N0M0 with any nuclear grade (> 80% of the cohort) would benefit from pembrolizumab. Additional factors are required to identify these patients. We aimed to examine postoperative recurrence factors in patients with pT3N0M0 clear cell renal cell carcinoma who were retrospectively included in the M0 intermediate-high-risk group.
Methods
We reviewed the medical records of 386 patients who underwent radical or partial nephrectomy for renal cell carcinoma, identifying 47 with pT3N0M0 clear cell renal cell carcinoma. Preoperative clinical and pathological data were collected. Patients were stratified by median value and category. Disease-free survival was calculated using Kaplan–Meier survival analysis, and the log-rank test was applied to compare survival curves.
Results
We showed that ≥ 68 years and necrosis were risk factors of worse disease-free survival (median disease-free survival; ≥68 year versus < 68 year: 24.46 months versus 97.54 months, P = 0.017, with necrosis versus without necrosis; 24.43 months versus 317.5 months, P = 0.023). Patients with a higher number of risk factors had significantly worse disease-free survival (median disease-free survival; no factor versus ≥ 68 years or necrosis versus ≥ 68 years and necrosis; 317.5 months versus 45.18 months versus 12.54 months).
Conclusion
Age and necrosis were suggested to impact on postoperative recurrence in the M0 intermediate-high-risk patients. It would support the indication for adjuvant therapy.
The effect of a customised digital adherence tool on HIV treatment outcomes in young people living with HIV in Blantyre, Malawi: a protocol for a randomised controlled trial
Authors: Msosa Takondwa Charles , Swai Iraseni , Ngowi Kennedy , de Wit Tobias Rinke , Aarnoutse Rob , Boer Marion Sumari-de , Nliwasa Marriott 
Published: June 2023

Abstract
Background

People living with HIV (PLHIV) have to take lifelong antiretroviral treatment, which is often challenging. Young people living with HIV (YPLHIV) have the lowest viral load suppression rates in Malawi and globally, mostly due to poor treatment adherence. This is a result of complex interactions of multiple factors unique to this demographic group. The use of digital health interventions, such as real time medication monitor (RTMM) based digital adherence tools (DATS) could improve ART adherence in YPLHIV and subsequently improve viral load suppression which in turn could lead to reduced HIV-associated morbidity and mortality.

Aim

To provide the evidence base for a digital adherence intervention to improve treatment outcomes in YPLHIV on ART.

Objectives

1. The primary objective is to determine the efficacy of a customised DAT compared to the standard of care in improving ART adherence in YPLHIV.
2. The secondary objective is to determine the efficacy of the customised DAT compared to the standard of care in improving viral load suppression in YPLHIV.

Methodology

This will be a parallel open label randomized control controlled two-arm trial in which non-adherent YPLHIV in selected ART facilities in Blantyre will be randomised in a 1:1 ratio to a customised DAT and standard care arms and followed up for 9 months. The primary outcome is proportion adherent at 9 months (>= 95% by pill count) and the secondary outcome is proportion viral load suppressed at 9 months (<200 copies/ml).

Discussion

There is a paucity of good quality evidence on effective digital health interventions to improve ART adherence and viral load suppression in YPLHIV globally and particularly in HIV high burden settings like Malawi. This study will provide good quality evidence on the effectiveness of a customised DAT in improving ART adherence and viral load suppression in this important demographic.

Trial registration

Pan African Clinical Trials Registry number: PACTR202303867267716
Date of Registration: 23 March 2023
URL of trial registry record: https:// pactr.samrc.ac.za
The attitudes of dental therapists and dental therapy educators in the South of England towards domiciliary dentistry: a qualitative study.
Authors: Quach Joshua , Patel Parul , Witton Robert , Vargas Carolina Machuca , Taylor Eleanor , Emanuel Robert 
Published: June 2023

Abstract
Introduction
Dental Therapists (DTs) are members of the dental team with a wide scope of practice, who support the provision of operative clinical care to several patient groups including those with vulnerabilities. One such group of vulnerable people is older patients who are often unable to attend general dental practices to access their dental care. A domiciliary or “home visit” may be required to deliver this care in a non-clinical setting.
Aim
To identify how dental therapists and dental therapy educators working in Southern England perceive domiciliary dental services and to explore what dental therapists and dental therapy educators consider to be the possible role of dental therapists in providing domiciliary dentistry.
Method
A qualitative research design using a thematic approach. Focus groups were conducted with different cohorts of dental therapists in different areas of Southern England between November 2022 and January 2023. Transcripts were analysed using thematic analysis.
Results
A total of five focus groups were held representing a diverse community of therapists. A number of different themes emerged including, knowledge of the domiciliary patient, barriers to the provision of domiciliary care for DTs, barriers to accessing domiciliary dentistry for patients, overcoming barriers, and benefits of providing domiciliary care
Conclusion
The concept of DTs providing domiciliary care was in general viewed positively. Several perceived barriers were reported including contractual, education and training issues. These barriers would need to be overcome to improve dental workforce skill-mix in delivery of domiciliary dental care.
Prevalence of genital mycoplasma in pregnancies with shortened cervix
Authors: Rauh Maximilian , Werle Franziska , Schmidt Börge , Litzka Christian , Solano Maria Emilia , Köninger Angela 
Published: June 2023

Abstract
Objective
To determine whether colonization with genital mycoplasma species (spp.) in patients presenting with a shortened cervix before 34th week of pregnancy is associated with preterm birth.
Methods
The collective of this retrospective study consisted of 100 pregnant women who presented to a German Tertiary Perinatal Center between 2017 and 2020 due to a shortened cervix defined as a cervical length of 25 mm or shorter measured by transvaginal ultrasound before 34 weeks of gestation. At the time of admission gestational age ranged from 18+4 to 33+3 weeks (+days) of pregnancy. All patients underwent urine polymerase chain reaction (PCR) for genital mycoplasma (Ureaplasma (U.) urealyticum, U. parvum, M. hominis or M. genitalium). Patients who were tested positive underwent a therapy with macrolides (azithromycin or clarithromycin).
Results
37% of the patients were positive for Ureaplasma spp. whereas 5% (5 patients) were Mycoplasma spp positive. All the latter were simultaneously colonized with Ureaplasma spp.
Ureaplasma positive patients were significantly younger than those who were tested negative. Median maternal age at examination was 30 years (a) versus 31a (p=0.04). There was no difference between ureaplasma positive and negative patients regarding median maternal body-mass-index (BMI) (kg/m2) (23.4 versus 22.3, p=0.41), cervical length at admission (mm) (15 versus 17, p=0.17), gestational age at examination (days, d) (198 versus 197, p=0.97) or gestational age at birth (d) (250 versus 257, p=0.33), respectively.
Comparing U. parvum positive and U. urealyticum positive patients, there was some weak indication that U. parvum positive patients may get a shortening of the cervix earlier in pregnancy, as the median gestational age at examination was 196d versus 215d (p=0.06).
Regarding mycoplasma positive and negative patients, there was no difference in all examined parameters.
Conclusions
Overall, one third of all women in our study with a shortened cervix before 34th week of pregnancy were colonized with genital Mycoplasma spp. We were able to show that pregnant women, who were treated with antibiotics when tested-positive for genital mycoplasma, gave birth at the same gestational age as patients with a shortened cervix without detected mycoplasma. This raises the question of whether routine testing and early antibiotic treatment should be established in prenatal care.
Fully biodegradable self-healing hydrogel prepared based on poly(aspartic acid) and pectin for drug delivery and anti-tumor therapy
Authors: Jia Boyang , Sun Weichen , Duan Wenhao , Ma Xiangbo , Wang Yong , Qin Jianglei 
Published: June 2023

Abstract
With biocompatibility and biodegradability, self-healing hydrogels prepared from biopolymers show great advantages in bioengineering and bioscience as drug delivery carrier. In this research, the biodegradable hydrogel was constructed based on poly(amino acid) of poly(aspartic acid) (PAsp) and pectin for in vivo antitumor applications as DOX release carrier. The PAsp with hydrazide groups and isopropyl groups (PAPH) was synthesized by ring opening of the polysuccinimide (PSI) by isopropylamine and hydrazine, and used to fabricate fully biodegradable hydrogel with oxidized pectin (OPec) through dynamic covalent bonds cross-linking. The regulatable mechanical strength of the hydrogel could adapt its bioapplication, and the excellent biocompatibility ensured biosafety in biomedical areas. Furthermore, the pectin backbone and the PAsp endowed the hydrogel with biodegradability both by enzyme and in vivo. The PAPH/Opec hydrogel as DOX carrier reduced the in vivo toxicity of the DOX while the antitumor efficacy of the drug was well preserved. As a result, this biodegradable PAPH/Opec hydrogel could find show great potential as sustained drug delivery vehicle in biomedical areas.