bluuebunny/crossref_metadata_2025_split huggingface dataset:
Certification of non-classicality in all links of a photonic star network without assuming quantum mechanics
Authors: Wang Ning-Ning , Pozas-Kerstjens Alejandro , Zhang Chao , Liu Bi-Heng , Huang Yun-Feng , Li Chuan-Feng , Guo Guang-Can , Gisin Nicolas , Tavakoli Armin 
Published: April 2023

AbstractNetworks composed of independent sources of entangled particles that connect distant users are a rapidly developing quantum technology and an increasingly promising test-bed for fundamental physics. Here we address the certification of their post-classical properties through demonstrations of full network nonlocality. Full network nonlocality goes beyond standard nonlocality in networks by falsifying any model in which at least one source is classical, even if all the other sources are limited only by the no-signaling principle. We report on the observation of full network nonlocality in a star-shaped network featuring three independent sources of photonic qubits and joint three-qubit entanglement-swapping measurements. Our results demonstrate that experimental observation of full network nonlocality beyond the bilocal scenario is possible with current technology.
Integration of clinical features and deep learning on pathology for the prediction of breast cancer recurrence assays and risk of recurrence
Authors: Howard Frederick M. , Dolezal James , Kochanny Sara , Khramtsova Galina , Vickery Jasmine , Srisuwananukorn Andrew , Woodard Anna , Chen Nan , Nanda Rita , Perou Charles M. , Olopade Olufunmilayo I. , Huo Dezheng , Pearson Alexander T. 
Published: April 2023

AbstractGene expression-based recurrence assays are strongly recommended to guide the use of chemotherapy in hormone receptor-positive, HER2-negative breast cancer, but such testing is expensive, can contribute to delays in care, and may not be available in low-resource settings. Here, we describe the training and independent validation of a deep learning model that predicts recurrence assay result and risk of recurrence using both digital histology and clinical risk factors. We demonstrate that this approach outperforms an established clinical nomogram (area under the receiver operating characteristic curve of 0.83 versus 0.76 in an external validation cohort,p = 0.0005) and can identify a subset of patients with excellent prognoses who may not need further genomic testing.
Aberrant neurophysiological signaling associated with speech impairments in Parkinson’s disease
Authors: Wiesman Alex I. , Donhauser Peter W. , Degroot Clotilde , Diab Sabrina , Kousaie Shanna , Fon Edward A. , Klein Denise , Baillet Sylvain ,   PREVENT-AD Research Group, Villeneuve Sylvia ,   Quebec Parkinson Network
Published: April 2023

AbstractDifficulty producing intelligible speech is a debilitating symptom of Parkinson’s disease (PD). Yet, both the robust evaluation of speech impairments and the identification of the affected brain systems are challenging. Using task-free magnetoencephalography, we examine the spectral and spatial definitions of the functional neuropathology underlying reduced speech quality in patients with PD using a new approach to characterize speech impairments and a novel brain-imaging marker. We found that the interactive scoring of speech impairments in PD (N = 59) is reliable across non-expert raters, and better related to the hallmark motor and cognitive impairments of PD than automatically-extracted acoustical features. By relating these speech impairment ratings to neurophysiological deviations from healthy adults (N = 65), we show that articulation impairments in patients with PD are associated with aberrant activity in the left inferior frontal cortex, and that functional connectivity of this region with somatomotor cortices mediates the influence of cognitive decline on speech deficits.
A comprehensive dataset of annotated brain metastasis MR images with clinical and radiomic data
Authors: Ocaña-Tienda Beatriz , Pérez-Beteta Julián , Villanueva-García José D. , Romero-Rosales José A. , Molina-García David , Suter Yannick , Asenjo Beatriz , Albillo David , Ortiz de Mendivil Ana , Pérez-Romasanta Luis A. , González-Del Portillo Elisabet , Llorente Manuel , Carballo Natalia , Nagib-Raya Fátima , Vidal-Denis Maria , Luque Belén , Reyes Mauricio , Arana Estanislao , Pérez-García Víctor M. 
Published: April 2023

AbstractBrain metastasis (BM) is one of the main complications of many cancers, and the most frequent malignancy of the central nervous system. Imaging studies of BMs are routinely used for diagnosis of disease, treatment planning and follow-up. Artificial Intelligence (AI) has great potential to provide automated tools to assist in the management of disease. However, AI methods require large datasets for training and validation, and to date there have been just one publicly available imaging dataset of 156 BMs. This paper publishes 637 high-resolution imaging studies of 75 patients harboring 260 BM lesions, and their respective clinical data. It also includes semi-automatic segmentations of 593 BMs, including pre- and post-treatment T1-weighted cases, and a set of morphological and radiomic features for the cases segmented. This data-sharing initiative is expected to enable research into and performance evaluation of automatic BM detection, lesion segmentation, disease status evaluation and treatment planning methods for BMs, as well as the development and validation of predictive and prognostic tools with clinical applicability.
Over-production of exopolysaccharide by Lacticaseibacillus rhamnosus CNCM I-3690 strain cutbacks its beneficial effect on the host
Authors: Martín R. , Benítez-Cabello A. , Kulakauskas S. , Viana M. V. C. , Chamignon C. , Courtin P. , Carbonne C. , Chain F. , Pham H. P. , Derrien Muriel , Bermúdez-Humarán L. G. , Chapot-Chartier M. P. , Smokvina T. , Langella P. 
Published: April 2023

AbstractMost lactobacilli produce extracellular polysaccharides that are considered to contribute to the probiotic effect of many strains. Lacticaseibacillus rhamnosus CNCM I-3690 is an anti-inflammatory strain able to counterbalance gut barrier dysfunction. In this study ten spontaneous variants of CNCM I-3690 with different EPS-production were generated and characterized by their ropy phenotype, the quantification of the secreted EPS and genetic analysis. Amongst them, two were further analysed in vitro and in vivo: an EPS over-producer (7292) and a low-producer derivative of 7292 (7358, with similar EPS levels than the wild type (WT) strain). Our results showed that 7292 does not have anti-inflammatory profile in vitro, and lost the capacity to adhere to the colonic epithelial cells as well as the protective effect on the permeability. Finally, 7292 lost the protective effects of the WT strain in a murine model of gut dysfunction. Notably, strain 7292 was unable to stimulate goblet cell mucus production and colonic IL-10 production, all key features for the beneficial effect of the WT strain. Furthermore, transcriptome analysis of colonic samples from 7292-treated mice showed a down-regulation of anti-inflammatory genes. Altogether, our results point out that the increase of EPS production in CNCM I-3690 impairs its protective effects and highlight the importance of the correct EPS synthesis for the beneficial effects of this strain.
The stability of transient relationships
Authors: Hidd Valentín Vergara , López Eduardo , Centellegher Simone , Roberts Sam G. B. , Lepri Bruno , Dunbar Robin I. M. 
Published: April 2023

AbstractIn contrast to long-term relationships, far less is known about the temporal evolution of transient relationships, although these constitute a substantial fraction of people’s communication networks. Previous literature suggests that ratings of relationship emotional intensity decay gradually until the relationship ends. Using mobile phone data from three countries (US, UK, and Italy), we demonstrate that the volume of communication between ego and its transient alters does not display such a systematic decay, instead showing a lack of any dominant trends. This means that the communication volume of egos to groups of similar transient alters is stable. We show that alters with longer lifetimes in ego’s network receive more calls, with the lifetime of the relationship being predictable from call volume within the first few weeks of first contact. This is observed across all three countries, which include samples of egos at different life stages. The relation between early call volume and lifetime is consistent with the suggestion that individuals initially engage with a new alter so as to evaluate their potential as a tie in terms of homophily.
Photoexcitation of perovskite precursor solution to induce high-valent iodoplumbate species for wide bandgap perovskite solar cells with enhanced photocurrent
Authors: Naikaew Atittaya , Krajangsang Taweewat , Srathongsian Ladda , Seriwattanachai Chaowaphat , Sakata Patawee , Burimart Supavudh , Sanglee Kanyanee , Khotmungkhun Kittikhun , Ruankham Pipat , Romphosri Suwat , Limmanee Amornrat , Kanjanaboos Pongsakorn 
Published: April 2023

AbstractSolution-processed organic–inorganic hybrid perovskite solar cells are among the candidates to replace the traditional silicon solar cells due to their excellent power conversion efficiency (PCE). Despite this considerable progress, understanding the properties of the perovskite precursor solution is critical for perovskite solar cells (PSCs) to achieve high performance and reproducibility. However, the exploration of perovskite precursor chemistry and its effects on photovoltaic performances has been limited thus far. Herein, we modified the equilibrium of chemical species inside the precursor solution using different photoenergy and heat pathways to identify the corresponding perovskite film formation. The illuminated perovskite precursors exhibited a higher density of high-valent iodoplumbate species, resulting in the fabricated perovskite films with reduced defect density and uniform distribution. Conclusively, the perovskite solar cells prepared by the photoaged precursor solution had not only improved PCE but also enhanced current density, confirmed by device performance, conductive atomic force microscopy (C-AFM), and external quantum efficiency (EQE). This innovative precursor photoexcitation is a simple and effective physical process for boosting perovskite morphology and current density.
A new extremophile ostracod crustacean from the Movile Cave sulfidic chemoautotrophic ecosystem in Romania
Authors: Iepure Sanda , Wysocka Anna , Sarbu Serban M. , Kijowska Michalina , Namiotko Tadeusz 
Published: April 2023

AbstractSulfidic cave ecosystems are remarkable evolutionary hotspots that have witnessed adaptive radiation of their fauna represented by extremophile species having particular traits. Ostracods, a very old group of crustaceans, exhibit specific morphological and ecophysiological features that enable them to thrive in groundwater sulfidic environments. Herein, we report a peculiar new ostracod species Pseudocandonamovilaensis sp. nov. thriving in the chemoautotrophic sulfidic groundwater ecosystem of Movile Cave (Romania). The new species displays a set of homoplastic features specific for unrelated stygobitic species, e.g., triangular carapace in lateral view with reduced postero-dorsal part and simplification of limb chaetotaxy (i.e., loss of some claws and reduction of secondary male sex characteristics), driven by a convergent or parallel evolution during or after colonization of the groundwater realm. P.movilaensis sp. nov. thrives exclusively in sulfidic meso-thermal waters (21 °C) with high concentrations of sulphides, methane, and ammonium. Based on the geometric morphometrics-based study of the carapace shape and molecular phylogenetic analyses based on the COI marker (mtDNA), we discuss the phylogenetic relationship and evolutionary implication for the new species to thrive in groundwater sulfidic groundwater environments.
Structural basis for sequence-specific recognition of guide and target strands by the Archaeoglobus fulgidus Argonaute protein
Authors: Manakova Elena , Golovinas Edvardas , Pocevičiūtė Reda , Sasnauskas Giedrius , Grybauskas Algirdas , Gražulis Saulius , Zaremba Mindaugas 
Published: April 2023

AbstractArgonaute (Ago) proteins are found in all three domains of life. The best-characterized group is eukaryotic Argonautes (eAgos). Being the structural core of RNA interference machinery, they use guide RNA molecules for RNA targeting. Prokaryotic Argonautes (pAgos) are more diverse, both in terms of structure (there are eAgo-like ‘long’ and truncated ‘short’ pAgos) and mechanism, as many pAgos are specific for DNA, not RNA guide and/or target strands. Some long pAgos act as antiviral defence systems. Their defensive role was recently demonstrated for short pAgo-encoding systems SPARTA and GsSir2/Ago, but the function and action mechanisms of all other short pAgos remain unknown. In this work, we focus on the guide and target strand preferences of AfAgo, a truncated long-B Argonaute protein encoded by an archaeon Archaeoglobus fulgidus. We demonstrate that AfAgo associates with small RNA molecules carrying 5′-terminal AUU nucleotides in vivo, and characterize its affinity to various RNA and DNA guide/target strands in vitro. We also present X-ray structures of AfAgo bound to oligoduplex DNAs that provide atomic details for base-specific AfAgo interactions with both guide and target strands. Our findings broaden the range of currently known Argonaute-nucleic acid recognition mechanisms.
Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers
Authors: Rybicka Magda , Verrier Eloi R. , Baumert Thomas F. , Bielawski Krzysztof Piotr 
Published: April 2023

AbstractThe study enrolled 284 patients with chronic hepatitis B virus infection. Participants included people with mild fibrotic lesions (32.5%), moderate to severe fibrotic lesions (27.5%), cirrhotic lesions (22%), hepatocellular carcinoma (HCC) in 5%, and people with no fibrotic lesions in 13%. Eleven SNPs within DIO2, PPARG, ATF3, AKT, GADD45A, and TBX21 were genotyped by mass spectrometry. The rs225014 TT (DIO2) and rs10865710 CC (PPARG) genotypes were independently associated with susceptibility to advanced liver fibrosis. However, cirrhosis was more prevalent in individuals with the GADD45A rs532446 TT and ATF3 rs11119982 TT genotypes. In addition, the rs225014 CC variant of DIO2 was more frequently found in patients with a diagnosis of HCC. These findings suggest that the above SNPs may play a role in HBV-induced liver damage in a Caucasian population.
Impact of the COVID-19 pandemic on young people with and without pre-existing mental health problems
Authors: Kleine Ronja , Galimov Artur , Hanewinkel Reiner , Unger Jennifer , Sussman Steve , Hansen Julia 
Published: April 2023

AbstractThe objective was to examine pandemic-related changes in depression and anxiety symptoms in adolescents and young adults in Germany considering pre-existing depression and anxiety problems. In this cross-sectional study, 11,523 adolescents and young adults aged 14–21 years who perceived an impact of the Coronavirus disease (COVID-19) pandemic on their mental health reported the frequencies of depression and anxiety symptoms retrospectively for different pre-pandemic and pandemic phases. Data were collected using web-based questionnaires between January 5th and February 20th, 2022. Depression and anxiety were assessed with a modified version of the Patient Health Questionnaire (PHQ-4). Scale-fit cut-offs were used to identify pre-existing elevated depression and anxiety scores. Multilevel mixed linear models were conducted to assess changes in depression and anxiety symptoms from 2019 to 2021 and compare for age, gender and pre-pandemic mental health problems. Among young people who were experiencing mental health changes as a result of the pandemic, the frequency of depression and anxiety symptoms increased during the COVID-19 pandemic. This association was moderated by age, gender, and pre-existing elevated depression/anxiety scores. For young people without elevated pre-pandemic depression/anxiety, the scores increased strongly over time, with 61% reporting elevated depression symptoms and 44% reporting elevated anxiety symptoms in 2021. In contrast, self-perceived change was minimal for adolescents and young adults with elevated pre-pandemic depression and anxiety. Among young people whose mental health has been affected by the COVID-19 pandemic, the group without pre-pandemic mental health conditions reported greater deterioration than those with elevated pre-pandemic depression and anxiety scores. Thus, adolescents and young adults without pre-existing depression and anxiety problems who perceived a change in general mental health due to the pandemic reported an alarming increase in symptoms of depression and anxiety during the COVID-19 pandemic period.
A new stochastic diffusion model for influence maximization in social networks
Authors: Rezvanian Alireza , Vahidipour S. Mehdi , Meybodi Mohammad Reza 
Published: April 2023

AbstractMost current studies on information diffusion in online social networks focus on the deterministic aspects of social networks. However, the behavioral parameters of online social networks are uncertain, unpredictable, and time-varying. Thus, deterministic graphs for modeling information diffusion in online social networks are too restrictive to solve most real network problems, such as influence maximization. Recently, stochastic graphs have been proposed as a graph model for social network applications where the weights associated with links in the stochastic graph are random variables. In this paper, we first propose a diffusion model based on a stochastic graph, in which influence probabilities associated with its links are unknown random variables. Then we develop an approach using the set of learning automata residing in the proposed diffusion model to estimate the influence probabilities by sampling from the links of the stochastic graph. Numerical simulations conducted on real and artificial stochastic networks demonstrate the effectiveness of the proposed stochastic diffusion model for influence maximization.
Improved diagnosis of histological capsule in hepatocallular carcinoma by using nonenhancing capsule appearance in addition to enhancing capsule appearance in gadoxetic acid-enhanced MRI
Authors: Nishioka Eiko , Sofue Keitaro , Maruyama Koji , Ueshima Eisuke , Ueno Yoshiko , Tsurusaki Masakatsu , Komatsu Shohei , Fukumoto Takumi , Murakami Takamichi 
Published: April 2023

AbstractTo assess the value of nonenhancing capsule by adding to enhancing capsule in gadoxetic acid-enhanced MRI (EOB-MRI) in comparison with contrast-enhanced CT (CE-CT) for diagnosing histological capsule in hepatocellular carcinoma (HCC). One-hundred fifty-one patients with HCC who underwent both CE-CT and EOB-MRI were retrospectively reviewed. Liver Imaging-Reporting and Data System (LI-RADS) v2018 imaging features, including enhancing and nonenhancing capsule were evaluated by two readers in CE-CT and EOB-MRI. Frequencies of each imaging feature were compared between CE-CT and EOB-MRI. The area under the receiver operating characteristic (AUC) curve for the diagnosis of histological capsule was compared across the following three imaging criteria: (1) enhancing capsule in CE-CT, (2) enhancing capsule in EOB-MRI, and (3) enhancing/nonenhancing capsule in EOB-MRI. Enhancing capsule in EOB-MRI was significantly less frequently depicted than that in CE-CT (p < 0.001 and = 0.016 for reader 1 and 2). Enhancing/nonenhancing capsule in EOB-MRI achieved a similar frequency of enhancing in CE-CT (p = 0.590 and 0.465 for reader 1 and 2). Adding nonenhancing capsule to enhancing capsule in EOB-MRI significantly increased AUCs (p < 0.001 for both readers) and achieved similar AUCs compared with enhancing capsule in CE-CT (p = 0.470 and 0.666 for reader 1 and 2). Adding nonenhancing capsule to the definition of capsule appearance can improve the diagnosis of capsule in EOB-MRI for the diagnosis of histological capsule in HCC and decrease discordance of capsule appearance between EOB-MRI and CE-CT.
The association of UBAP2L and G3BP1 mediated by small nucleolar RNA is essential for stress granule formation
Authors: Asano-Inami Eri , Yokoi Akira , Sugiyama Mai , Hyodo Toshinori , Hamaguchi Tomonari , Kajiyama Hiroaki 
Published: April 2023

AbstractStress granules (SGs) are dynamic, non-membranous structures composed of non-translating mRNAs and various proteins and play critical roles in cell survival under stressed conditions. Extensive proteomics analyses have been performed to identify proteins in SGs; however, the molecular functions of these components in SG formation remain unclear. In this report, we show that ubiquitin-associated protein 2-like (UBAP2L) is a crucial component of SGs. UBAP2L localized to SGs in response to various stresses, and its depletion significantly suppressed SG organization. Proteomics and RNA sequencing analyses found that UBAP2L formed a protein-RNA complex with Ras-GTP-activating protein SH3 domain binding protein 1 (G3BP1) and small nucleolar RNAs (snoRNAs). In vitro binding analysis demonstrated that snoRNAs were required for UBAP2L association with G3BP1. In addition, decreased expression of snoRNAs reduced the interaction between UBAP2L and G3BP1 and suppressed SG formation. Our results reveal a critical role of SG component, the UBAP2L/snoRNA/G3BP1 protein-RNA complex, and provide new insights into the regulation of SG assembly.
Moderate white light exposure enhanced spatial memory retrieval by activating a central amygdala-involved circuit in mice
Authors: Shang MengJuan , Shen MeiLun , Xu RuoTong , Du JingYu , Zhang JiMeng , OuYang Ding , Du JunZe , Hu JunFeng , Sun ZhiChuan , Wang BingXia , Han Qian , Hu Yang , Liu YiHong , Guan Yun , Li Jing , Guo GuoZhen , Xing JunLing 
Published: April 2023

AbstractLight exposure can profoundly affect neurological functions and behaviors. Here, we show that short-term exposure to moderate (400 lux) white light during Y-maze test promoted spatial memory retrieval and induced only mild anxiety in mice. This beneficial effect involves the activation of a circuit including neurons in the central amygdala (CeA), locus coeruleus (LC), and dentate gyrus (DG). Specifically, moderate light activated corticotropin-releasing hormone (CRH) positive (+) CeA neurons and induced the release of corticotropin-releasing factor (CRF) from their axon terminals ending in the LC. CRF then activated tyrosine hydroxylase-expressing LC neurons, which send projections to DG and release norepinephrine (NE). NE activated β-adrenergic receptors on CaMKIIα-expressing DG neurons, ultimately promoting spatial memory retrieval. Our study thus demonstrated a specific light scheme that can promote spatial memory without excessive stress, and unraveled the underlying CeA-LC-DG circuit and associated neurochemical mechanisms.