bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stroboscopic control and tracking of periodic states
Authors: Dittus Anna , Kruse Niklas , Wallner Hannes , Böttcher Lukas , Barke Ingo , Speller Sylvia , Starke Jens , Just Wolfram 
Published: June 2023

Abstract
Numerical continuation tools are nowadays standard methods for the bifurcation analysis of dynamical systems. Unfortunately the full power of these methods is still unavailable in experiments, in particular, if no underlying mathematical model is at hand. We here aim to narrow this gap by providing control based continuation of periodic states which can be ultimately implemented in real world experimental setups. Taking inspiration from atomic force microscopy, we develop experimentally relevant control and tracking tools for time periodic solutions in driven nonlinear oscillator systems based on stroboscopic maps.
MSC Classification: 37N35 , 34C15 , 34C55 , 93B52 , 93A30
Reference values of cardiopulmonary exercise test parameters in the contemporary paediatric population
Authors: Amedro Pascal , Matecki Stefan , Santos Taissa Pereira dos , Guillaumont Sophie , Rhodes Jonathan , Yin Suellen Moli , Hager Alfred , Hock Julia , Villeon Gregoire De La , Moreau Johan , Requirand Anne , Souilla Luc , Vincenti Marie , Picot Marie-Christine , Huguet Helena , Mura Thibault , Gavotto Arthur 
Published: June 2023

Abstract
Background: The evaluation of health status by cardiopulmonary exercise test (CPET) has shown increasing interest in the paediatric population. Our group recently established reference Z-score values for paediatric cycloergometer VO2max, applicable to normal and extreme weights, from a cohort of 1141 healthy children. There are currently no validated reference values for the other CPET parameters in the paediatric population. This study aimed to establish, from the same cohort, reference Z-score values for the main paediatric cycloergometer CPET parameters, apart from VO2max.
Results: In this cross-sectional study, 909 healthy children aged 5 to 18 years old underwent a CPET. Linear, quadratic, and polynomial mathematical regression equations were applied to identify the best CPET parameters Z-scores, according to anthropometric parameters (sex, age, height, weight, and BMI). This study provided Z-scores for maximal CPET parameters (heart rate, respiratory exchange ratio, workload, and oxygen pulse), submaximal CPET parameters (ventilatory anaerobic threshold, VE/VCO2 slope, and oxygen uptake efficiency slope), and maximum ventilatory CPET parameters (tidal volume, respiratory rate, breathing reserve, and ventilatory equivalent for CO2 and O2).
Conclusions: This study defined paediatric reference Z-score values for the main cycloergometer CPET parameters, in addition to the existing reference values for VO2max, applicable to children of normal and extreme weights. Providing Z-scores for CPET parameters in the paediatric population should be useful in the follow-up of children with various chronic diseases. Thus, new paediatric research fields are opening up, such as prognostic studies and clinical trials using cardiopulmonary fitness outcomes.
Trial registration: NCT04876209 - Registered 6 May 2021 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04876209.
Circling the Void: Using Heidegger and Lacan to think about Large Language Models
Authors: Heimann Marc , Hübener Anne-Friederike 
Published: June 2023

Abstract
The essay aims to unite two currently distinct lines of thinking and working with language. Large Language Models and continental philosophy, especially Martin Heidegger’s thinking about language and, building upon Sigmund Freud, Jaques Lacan’s structural psychoanalysis. We show that the concept of language that Heidegger, Freud and Lacan discuss and utilize in clinical frameworks is matched quite strongly by modern LLMs. This allows us to discuss a problem of negation and negativity that is central to the continental discourse but missing in current LLM research. This also means that we offer a radically different approach than it is usual in the philosophy of artificial intelligence, since we base our concepts on thinkers that are often disregarded in the analytic philosophy discourse that is closer linked to AI research. To this end we also mark, where the ontological differences of the proposed approach lie. However, our aim is to address AI researcher and continental philosophers.
Fresh Evidence from Temperature Effects on Growth and Economic Policy Uncertainty: A Panel Quantile Approach
Authors: Leventis Flora , Palaios Panagiotis 
Published: June 2023

Abstract

This paper provides fresh evidence of temperature effects on GDP per capita growth and economic policy uncertainty (epu). We apply the quantile via moments methodology (Machado and Santos Silva, 2019) in a sample of 35 countries for the period 1980–2021, the most current time frame of the work we reviewed. To the best of our knowledge, temperature effects on epu, in a panel quantile setting, have not been examined before. Our empirical results provide evidence in favor of asymmetric temperature impacts on both growth rates and epu. Specifically, we find that: First, the impact of temperature and of its interaction with economic policy uncertainty on the growth rate is negative, quadratic, and more intense for poorer countries. Second, the combined temperature and policy uncertainty effect on growth rates is of greater magnitude compared to the simple temperature effect. Third, hotter countries are more vulnerable to economic policy uncertainty, with the effect being more pronounced as uncertainty increases.
JEL Classification: C33, O13, Q54, Q56.
Musashi-1 regulates cell cycle and confers resistance to cisplatin treatment in Group 3/4 medulloblastomas cells
Authors: Chagas Pablo Shimaoka , Veronez Luciana Chain , de Sousa Graziella Ribeiro , Cruzeiro Gustavo Alencastro Veiga , Corrêa Carolina Alves Pereira , Saggioro Fabiano Pinto , Queiroz Rosane Gomes de Paula , Marie Suely Kazue Nagahashi , Brandalise Silvia Regina , Cardinalli Izilda Aparecida , Yunes José Andres , Júnior Carlos Gilberto Carlotti , Machado Hélio Rubens , Santos Marcelo Volpon , Scrideli Carlos Alberto , Tone Luiz Gonzaga , Valera Elvis Terci 
Published: June 2023

Abstract
Groups (Grp) 3 and 4 are aggressive molecular subgroups of medulloblastoma (MB), with high rates of leptomeningeal dissemination. To date, there is still a paucity of biomarkers for these subtypes of MBs. In this study, we investigated the clinical significance and biological functions of Musashi-1 (MSI1) in Grp3 and Grp4-MBs. First, we assessed the expression profile of MSI1 in 59 primary MB samples (15-WNT, 18-SHH, 9-Grp3, 17-Grp4 subgroups) by qRT-PCR. MSI1 mRNA expression levels were also validated in an additional public dataset of MBs (GSE85217). The ROC curve was used to validate the diagnostic standards of MSI1 expression. Next, the potential correlated cell-cycle genes were measured by RNA-Seq. Cell cycle, cell viability, and apoptosis were evaluated in a Grp3/Grp4 MB cell line after knockdown of MSI1 and cisplatin treatment. We identified an overexpression of MSI1 with a high accuracy to discriminate Grp3/Grp4-MBs from non-Grp3/Grp4-MBs. We identified that MSI1 knockdown not only triggered transcriptional changes in the cell cycle pathway, but also affected G2/M phase in vitro, supporting the role of knockdown of MSI1 in cell cycle arrest. Lastly, MSI1 knockdown decreased cell viability and sensitized D283-Med cells to cisplatin treatment by enhancing cell apoptosis. Based on these findings, we suggest that MSI1 modulates cell cycle progression and may play a role as biomarker for Grp3/Grp4-MBs. In addition, MSI1 knockdown combined with cisplatin may offer a potential strategy to be further explored in Grp3/Grp4-MBs.
Evaluation of chemical constituents of Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia) as adenosine A1/A2A receptor ligands
Authors: Gouws Liezel , Rensburg Helena Dorathea Janse van , Terre'Blanche Gisella , Walt Mietha Magdalena Van der 
Published: June 2023

Abstract
Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia) are popular tisanes in South Africa and are of growing interest due to the wide variety of flavonoids and other phytochemicals they contain. Despite their history as herbal teas and traditional medicines, the chemical constituents of these tisanes have yet to be studied for their effects on adenosine receptors. Flavonoids have previously shown promising affinity toward the adenosine receptors. A series of 30 commercially available constituents of Rooibos and Honeybush were investigated via radioligand binding studies to determine their adenosine A1 and A2A receptor affinity at both rat and human subtypes in order to establish structure-activity relationships and identify novel adenosine receptor ligands. In addition, in silico evaluations of the 30 test compounds were also performed to investigate their physiochemical and pharmacokinetic properties. The most promising constituent was kaempferol (28) which showed sub-micromolar affinity towards the rat A1 subtype (rA1Ki = 0.7287 μM; hA1Ki = 9.88 µM) and acted as an antagonist toward adenosine rA1 receptors. Additionally, quercetin (2), chrysoeriol (8), luteolin (9), eriodyctiol (12), and naringenin (27) also showed adenosine A1 and/or A2A receptor affinity. It was observed that a flavonol scaffold is preferred to flavone and flavanone scaffolds, and within the flavonols, C4’-OH substitution on ring B is preferred to C3’,4’-diOH substitution. These phytochemicals, specifically kaempferol (28), may be considered lead-like and valuable in designing novel ligands, based on in vitro and in silico evaluation.
Deployment Drift Detection in Spatiotemporal Fusion Intelligent Sensor Networks
Authors: Qiao Libo , Zhu Qianwen , Du Rongfang , Han Zongyi , Wang Wei 
Published: June 2023

Abstract

The node deployment problem is a primary concern in wireless sensor network (WSN) technologies. Optimizing the placement of nodes can significantly enhance network monitoring performance. In contrast to most existing algorithms for optimal deployment of sensor network nodes, this paper proposes a spatiotemporal fusion algorithm for detecting deployment drift in intelligent sensor networks (ISNs), which aims to determine when sensor network deployment needs to be optimally updated. The algorithm begins by collecting the location information of each sensor and dividing the network space into several regions using Voronoi diagrams. Subsequently, the clustering centroids of each region are calculated based on the monitored data, serving as new nodes for constructing a graph signal. Graph neural networks (GNNs) are utilized to explore the structural information in graphs to obtain graph embedding. Additionally, the Transformer is employed to capture tensor graph embedding within a fixed window length, emphasizing temporal characteristics. The ideal timing for updating network deployment is determined by comparing tensor graph representations between adjacent windows. Experimental results on the Intel_Lab_Data and CIMIS validate the efficacy of the proposed approach.
Assessment of potential drug-to-drug interaction with antifungal agents in men with cardiovascular disease – a cross-sectional study of Polish population
Authors: Rys-Czaporowska Anna , Szykut-Badaczewska Agata , Ulc Ewelina , Platek Anna E. , Semczuk-Kaczmarek Karolina , Olszewska Małgorzata , Religioni Urszula , Merks Piotr , Szymanski Filip M. 
Published: June 2023

Abstract
Background
Treatment of dermatological diseases in patients with concomitant cardiovascular is difficult due to reported interactions between antimycotic and cardiac drugs. The aim of the study was to assess the prescription frequency of drugs, causing potential interaction with antifungal drugs of superficial mycoses in patients with cardiovascular disease.
Methods
The study consisted of 166 consecutive men discharged from a tertiary cardiac department who were screened for topical fungal infections and were analyzed for drugs prescribed at discharge, with possible interference with typically used antimycotic treatment.
Results
The mean age of the study population was 62.8 ± 12.1 years. 57 (49.1%) of patients had a clinical suspicion of superficial mycosis and were referred for further dermatological investigation. The use of cardiovascular drugs was frequent, with 24.5% taking NOACs, 54.8% receiving diuretics and 76.5% receiving statins. No difference in the use of any drug was noted according to the mycosis status.
Conclusions
Polypharmacy with drugs exhibiting a potential for drug-to-drug interaction with antifungal agents is common in patients with cardiovascular disease. When choosing the appropriate option for superficial mycoses treatment, the knowledge of potential interaction is crucial in dermatologists and cardiologists to avoid their harmful consequences including serious bleeding or live threatening arrhythmias.
The chloroplasts genomic analyses of Caragana arborescens and Caragana opulens
Authors: Liu LiE , Li HongYan , Li JiaXin , Li XinJuan , Hu Na , Wang Honglun , Zhou Wu 
Published: June 2023

Abstract
Background
Numerous species within the genus Caragana have high ecological and medicinal value. In this genus, however, species identification based on morphological characteristics is quite complicated; this issue can be resolved by analyzing the complete plastid genomes.
Results
We obtained the chloroplast genomes of two species using lllumina sequencing technology: Caragana arborescens and Caragana opulens, with lengths of 129,473 bp and 132,815 bp, respectively. The absence of inverted repeat sequences in the two species allowed them to be ascribed to the inverted repeat-lacking clade (IRLC). They comprise a total of 111 distinct genes (4 rRNA, 31 tRNA, and 76 protein-coding genes). In addition, 16 genes containing introns were identified in two genomes, the majority of which contained a single intron. C. arborescens and C. opulens were found to contain 129 and 229 repeats, as well as 277 and 265 simple repeats, respectively. The codon usage bias analysis revealed that the two Caragana species exhibit similar codon usage patterns. rpoC2-rps2, accD-cemA, rps18-clpP, rpoA-rpl36, and rpl2-rpl23 were identified as the five regions most likely to be mutated based on analysis of nucleotide diversity (Pi). Analysis of sequence divergence revealed that certain intergenic regions (matK-rbcL, psbM-petN, atpA-psbI, petA-psbL, psbE-petL, and rps7-rps12) are highly variable. Phylogenetic analysis showed that C. arborescens and C. opulens were related and clustered together as the other four Caragana species. And the genus Astragalus and Caragana were relatively closely related.
Conclusions
In our research, the chloroplast genomes of C. arborescens and C. opulens were sequenced and their genomic structural characteristics were compared. We have also confirmed that both plants lack IR regions, which resulted in unclear boundary analysis, and that two plants could be classified as IRLC. This study provides a foundation for future phylogenetic research and the development of molecular markers for Caragana plants.
Parasites infection in Black-necked Cranes Revealed by Piloting High-throughput
Sequencing of V4 and V9 Regions of 18S rDNA
Authors: wang yeying , Zhang Yu , Zhang Xu , Li Xianyu , Su Haijun 
Published: June 2023

Abstract
Illumina high-throughput sequencing is a representative tool for understanding the diversity of eukaryotic community. We compared the parasites diversity of 24 fecal samples from the wintering black-necked cranes in Caohai wetland using the Illumina sequencing of 18S rDNA V4 and V9 regions. Globally, 237 operational taxonomic units (OTUs) and 197 OTUs were detected using the V4 and V9 primer sets, respectively. Taxonomic analyses of these OTUs revealed that the number of phyla, families, genera and species in V4 datasets were higher than V9 datasets and at the level of class and order was lower than V9 datasets. The alpha diversity index for V4 were all higher than V9, which also illustrates that datas from the V4 region are more rich. However, the V9 datasets detected Echinostoma caproni which was a common parasite in birds while the V4 datasets were failed, so we strongly recommend both V4 and V9 regions be used to assess the diversity within the parasites in fecal samples. After in-depth discussion on the species level and phylogenetic analysis of parasites, we finally confirmed that the black-necked cranes were infected with E. reichenowi, E. gruis, C. struthionis and E. caproni. Among them, E. caproni was a zoonotic parasite, C. struthionis had unknown pathogenicity, and E. reichenowi and E. gruis had the greatest threat to the health of black-necked cranes. These four parasites should be given great attention and sustained attention in the follow-up study. The results enriched the application of high-throughput sequencing technology in bird parasite detection.
Evaluation of capacitance-based soil moisture sensors in IoT based automatic basin irrigation system
Authors: Pramanik Monalisha , Khanna Manoj , Singh Man , Singh D K , Sudhishri Susama , Bhatia Arti , Ranjan Rajeev 
Published: June 2023

Abstract

A field experiment was carried out at the Research farm, ICAR-Indian Agricultural Research Institute, New Delhi under bare soil and wheat crop to evaluate the performance of capacitance-based soil moisture sensors in an automatic basin irrigation system. Three capacitance-based soil moisture sensors (SMS) were placed at 25%, 50% and 75% of field length at 37.5 cm (SMS-1), 15 cm (SMS-2) and 7.5 cm (SMS-3) soil depth, respectively. An automatic basin irrigation system consists of capacitance-based soil moisture sensors, a check gate at the inlet and a cloud server. The system could be operated from anywhere with a mobile/ web-based application. Irrigation events were scheduled when soil moisture reached up to 40, 30, and 20% of field capacity. A total of nine irrigation events were monitored over three months period. SMSs were evaluated based on performance in terms of quick response, accuracy, robustness and energy consumption. The results showed that the capacitance-based soil moisture sensors quickly responded to moisture changes and successfully sent data at predefined time intervals. The capacitance-based soil moisture sensors successfully schedule irrigation in wheat crop based on the real time soil moisture status and helped to save 72.5 mm water as compared to manual control irrigation system. The soil moisture sensor recorded a 2 to 8% error compared to the gravimetric method. The solar-powered soil moisture sensor worked well with a 4 to 5 hrs solar charge. It was found that the soil moisture sensor was quite robust and easy to handle and requires the least maintenance. The low energy consumption by the sensor makes it suitable to incorporate in a wireless automatic basin irrigation system.
Formulation, standardization, and evaluation of the anti-colitis activity of Qur-e Gol, a Persian polyherbal formulation in acetic acid-induced colitis
Authors: Baghaei Amir , Amrollahi Zahra , Sadeghi-Ghadi Zaynab , Amiri-Andebili Marziyeh , Bozorgi Atefeh Hajiagha , Jahandideh Maryam , Shirzad Meysam , Ghane Talat , Ahmadian-Attari Mohammad Mahdi 
Published: June 2023

Abstract
Introduction: Inflammatory bowel disease (IBD) is one of the chronic diseases of the gastrointestinal tract. The prevalence of IBD is worldwide but socioeconomic impacts of it on low- and middle-income countries are more destructive. Therefore, investigating the effects of inexpensive available traditional formulations on IBD is noticeable. The aim of this study was to investigate anti-ulcerative colitis activity of a traditional formulation, Qurs-e Gol, on acetic acid-induced colitis in rats. Methods: Damask rose, rumex, starch, gum Arabic, and gum tragacanth were separately ground, sifted, and then mixed with suitable excipients to formulate Qurs-e Gol tablet. Induction of colitis in male Wistar rats was done by intrarectal administration of 3% acetic acid. 24 hours after induction of colitis, the rats received Qurs-e Gol with the doses of 200, 400, and 800 mg/ kg by oral gavage and dexamethasone with 2 mg/kg by i.p. injection. Two another groups including sham and negative control (receiving 14-day oral normal saline) were also used. Treatment continued for 14 days and 24 hr after the last day, blood samples were taken from the heart to measure serum TNF-α. Animals were finally sacrificed to remove their colon for histopathologic studies. Results: Macroscopic evaluations showed that 400 and 800 mg/kg of Qurs-e Gol for 14 days attenuate inflammation and ulcers compared with the control group (P < 0.001). Microscopic analysis showed that these doses can reduce depth of lesions in colon (P < 0.001). anti- colitis effects of these doses were comparable with dexamethasone. The best suppression of tumor necrosis factor-α was observed at a dose of 800 mg/kg (P < 0.001) but both 200 and 400 mg/kg were also effective (P < 0.01). Conclusion: Qurs-e Gol has anti-inflammatory effects in ulcerative colitis and can be a good candidate for future animal and human studies.
In vitro cadmium exposure induces structural damage and endothelial dysfunction in female rat aorta
Authors: Mulher Lorraine Christiny Costa Sepulchro , Simões Rakel Passos , Rossi Karoline Alves , Schereider Ingridy Reinholz Grafites , Nascimento Camilla Lóren Silva , Ávila Renata Andrade , Padilha Alessandra Simão 
Published: June 2023

Abstract
Cadmium is a heavy metal that is widespread in the environment and has been described as a metalloestrogen and a cardiovascular risk factor. Experimental studies conducted in male animals have shown that cadmium exposure induces vascular dysfunction, which could lead to vasculopathies caused by this metal. However, it is necessary to investigate the vascular effects of cadmium in female rats to understand its potential gender-specific impact on the cardiovascular system. While its effects on male rats have been studied, cadmium may act differently in females due to its potential as a metalloestrogen. In vitro studies conducted in a controlled environment allow for a direct assessment of cadmium's impact on vascular function, and the use of female rats ensures that gender-specific effects are evaluated. Therefore, the aim of this study was to investigate the in vitro effects of Cadmium Chloride (ClCd2, 5µM) exposure on vascular reactivity in the isolated aorta of female Wistar rats. Exposure to ClCd2 damaged the architecture of the vascular endothelium. ClCd2 incubation increased the production and release of O2•-, reduced the participation of potassium (K+) channels, and increased the participation of the angiotensin II pathway in response to phenylephrine. Moreover, estrogen receptors alpha (Erα) modulated vascular reactivity to phenylephrine in the presence of cadmium, supporting the hypothesis that cadmium could act as a metalloestrogen. Our results demonstrated that in vitro cadmium exposure induces damage to endothelial architecture and an increase in oxidative stress in the isolated aorta of female rats, which could precipitate vasculopathies.