bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low expression of NR1D1 and NR2E3 is associated with advanced features of retinoblastoma
Authors: Ding Jie , Sun Jie , Ma Rui-Qi , Zheng Ke , Han Yi-Nan 
Published: March 2023

Abstract
Purpose
To investigate the expression of nuclear receptor subfamily 1 group D member 1 (NR1D1) and nuclear receptor subfamily 2 group E Member 3 (NR2E3) in retinoblastoma (RB) and their correlation with the clinical and pathological features of RB.
Methods
Immunohistochemical (IHC) assays were performed to detect and evaluate the expression levels of NR1D1 and NR2E3 in paraffin-embedded tissue samples. The relationship between the expression levels and clinicopathological characteristics of RB patients was analyzed using the χ2 test or Fisher exact test.
Results
A total of 51 RB patients were involved in this research. The expression levels of NR1D1 (P=0.010) and NR2E3 (P=0.007) were significantly lower in RB tumor tissues than in normal retina. The expression levels of NR1D1 and NR2E3 were less positive in RB patients with advanced stages (P=0.007, P=0.015), choroidal infiltration (P=0.003, P=0.029), and optic nerve infiltration (P=0.036, P=0.003). In addition, a low expression level of NR2E3 was associated with high-risk pathology (P=0.025) and necrosis (P=0.035) of RB tissues.
Conclusion
The expression levels of NR1D1 and NR2E3 were decreased in RB and closely associated with the clinical stage and high invasion of the disease.These findings provide new insights into the mechanism of RB progression and suggest that NR1D1 and NR2E3 could be potential targets for treatment strategies.
A Week in the Life of the Human Brain: Stable States Punctuated by Chaotic-Like Transitions
Authors: Wang Maxwell , G'Sell Max , Richardson R. Mark , Ghuman Avniel 
Published: March 2023

Abstract
Critical neurocognitive processes, such as performing natural activities and fluctuations of arousal, take place over minutes-to-days in real-world environments. Here we harness the opportunity to study brain dynamics during real-world behavior continuously for 3-12 days using multi-electrode intracranial recordings in twenty humans. During this time, participants engaged in natural activities, including interacting with friends, family, and staff, watching TV, sleeping, etc., with simultaneous neural and video recordings. We found that brain network dynamics predicted neurocognitive phenomena such as circadian rhythm, arousal, and multiple aspects of behavior (socializing, watching a screen, etc.). The individual functional networks, as well as their pairwise interactions, possessed simple and stable dynamic properties that were conserved over days. In contrast to single or paired network behavior, the mixture of all functional networks showed patterns of “punctuated equilibrium”: periods where networks would remain in stable states that corresponded to behavior and were interrupted by transitory bursts that were difficult to predict, displayed chaotic characteristics, and coincided with behavioral transitions. Brain state statistics displayed power laws characteristic of critical dynamics that are a trait of systems where complexity emerges from simple and stable building blocks. These results indicate that the complex and flexible brain dynamics that underpin real-world behavior are an emergent property of mixtures of individual, stable networks with simple dynamics.
Harnessing the Therapeutic Potential of Antimicrobial Peptides for
Cancers: State of the Art
Authors: Mahjoubin-Tehran Maryam , Rezaei Samaneh , Aghaee-Bakhtiari Seyed Hamid , Sahebkar Amirhossein , Oskuee Reza Kazemi , Mahmoudi Ali , Jalili Amin 
Published: March 2023

Abstract:
Despite significant breakthroughs in cancer treatment, cancer remains a serious global health concern that takes thousands of lives each year. Still, drug resistance and adverse effects are the main problems in conventional cancer therapeutic approaches. Thus, the discovery of new anti-cancer agents with distinct mechanisms of action is a critical requirement that offers significant ob-stacles. Antimicrobial peptides (AMPs), which can be found in various forms of life, are recognized as defensive weapons against infections of microbial pathogens. Surprisingly, they are also capable of killing a variety of cancer cells. These powerful peptides can cause cell death in the gastrointesti-nal, urinary tract, and reproductive cancer cell lines. To emphasize the anti-cancer properties of AMPs, we summarize the research that examined their impact on cancer cell lines in this review.
An Update on Eating Disorders
Authors: Hussain Md. Sadique , Sharma Neha , Khurana Navneet 
Published: March 2023

Abstract:
It is no surprise that eating disorders (EDs) are increasing all over the planet. With the
emergence of global westernization, development in technology, and societal changes, nearly all
regions of the globe have been influenced by the concept of a perfect body image and height.
EDs are a considerable public concern, a bewilderment for psychologists and a challenge for
physicians. The primary EDs include anorexia nervosa (AN), bulimia nervosa (BN), and binge
eating disorder (BED). AN is an ED that is psychological and possibly life-threatening. Usually,
people with AN experience an exceedingly low body weight due to their height and body shape.
The highest rate of occurrence is between 14 and 17 years of age. BN is an extreme, lifethreatening,
neurological ED in which you have binge eating cycles. You may not have any
sense of balance in your diet throughout these binges. The weight-control engagement of patients
with AN and BN results in various physiological shifts. EDs can control your lives and can be
quite hard to cope with. Yet you will develop a better understanding of who you are by therapy,
return to healthy eating and exercise, and undo any of the severe complications of AN. Investigation
into EDs has yielded valuable new information over the past few decades, notably involving
the psychological features and care of patients. The purpose of this study/review is to expand the
knowledge of the people about these EDs, their global burden, diagnostic criteria, risk factors,
medical complications, management, and the newly added avoidant/restrictive food intake disorder.
Synthesis and Electrochemical Applications of Carbon Nano-onions
Authors: Castaño Jorge A. , Betancourth Jolaine G. , Caicedo Dahiana L. , Visbal Renso , Chaur Manuel N. 
Published: March 2023

Abstract:
Carbon nano-onions, a family of carbon nanomaterials, consist of multiple concentric fullerene-
like carbon shells which are highly defective and disordered. Due to their unique physicochemical
properties, such as high conductivity, high surface area, biocompatibility, thermal stability, and
others, they are promising nanomaterials for different electrochemical applications. In this sense, this
review outlines the synthetic methods available to afford carbon nano-onions in their pristine, functionalized
(covalent and non covalent) and doped forms and their use in energy storage, electrocatalysis
and sensing. Particularly, we review the performance and properties of carbon nano-onions as electrode
materials for supercapacitors, electrocatalysts in different reactions for fuel cells, and electrode
materials for sensors. In the last decade, as we will discuss, scientists have found that functionalized
and doped carbon nano-onions have better electrochemical properties than pristine carbon nanoonions,
such as specific capacitance, surface wettability, energy power, adsorption on an electrode
surface, and charge delocalization, among others.
Myocarditis and Pericarditis Related to mRNA COVID-19 Vaccination: A
Case Report
Authors: María Pérez López Elena , Diego Rangel Sousa , Jorge Navarro Roldán 
Published: March 2023

Introduction:
Reported cases after the post-commercialization phase of mRNA vaccines
against COVID-19 have revealed that myocarditis and pericarditis may occur predominantly in
male adolescents after the second dose of the vaccine.

Case Presentation:
We report two cases of cardiac disorders associated with mRNA COVID-19
vaccination, both of them in 15 year-old males. One of the patients presented acute pericarditis and
the second one presented acute myocarditis with left ventricular dysfunction at hospital discharge.

Discussion and Conclusion:
Physicians should be aware with the typical manifestations of these
cardiovascular events after the vaccination and report suspicious cases to pharmacovigilance agencies
as soon as possible. The population should rely on the pharmacovigilance system that continues
to recommend vaccination as the most effective strategy to reduce the negative consequences
of the pandemic.
The Cell Death and Signal Transduction Mechanisms in Colorectal Carcinogenesis:
Recent Advances
Authors: Kashyap Monu Kumar , Ved Akash , Yadav Rajiv Ratan Singh , Singh Akhand Pratap , Kushwaha Mahima , Shukla Karuna S. 
Published: March 2023

Abstract:
In underdeveloped nations, colorectal carcinogenesis (CRC) is a significant health issue. It is the third most
common outcome of cancer death. Despite a variety of therapy options, new medications are needed to lessen the severity
of this condition. In the colon, adenomatous polyps are the most common cause of CRC, occurring in 45 percent
of cases, particularly in patients over 60 years old. Inflammatory polyps are acquiring popularity in CRC, as well as
inflammation appears to exert a function in the disease, according to mounting research. The azoxymethane, dimethyl
hydrazine, APCmin/+ mouse model, and a combination of sulfated polysaccharides composed of dextran and sulfated
and dimethylhydrazine are among the experimental models used to study CRC in animals. Numerous signal transduction
pathways are engaged as CRC progresses. The p53, TGF-β, Delta-Notch, Salvador-Warts-Hippo (SWH), and
Kelch-like ECH associated protein 1 pathways are among the key signal transduction pathways. To decide cell destiny,
several signalling pathways work in tandem with the death of cell modalities, such as autophagy, necroptosis,
and apoptosis. In our lab, we have spent a lot of time looking into the cell signalling and mechanisms of cell death in
CRC. The pathogenesis of CRC, as well as the associated cell death and cell signalling pathways, are summarised in
this study.
Parametric Study on the Influence of Pedestrians' Road Crossing Pattern on Safety
Authors: Prakash Sathya , Karuppanagounder Krishnamurthy 
Published: March 2023

Objective:
The present research concentrates on studying the road crossing time of pedestrians based on their pattern of the road crossing. The factors that influence the road occupancy time due to the irregular road crossing patterns of pedestrians have been studied.

Methods:
The research used a videographic survey of three midblock locations with different land-use types. The pedestrian variables from the video data are extracted to excel using a custom-made video player. The data set consists of 8718 pedestrian data, including all three sites, and the data is analysed using statistical methods. A binary logit analysis is performed to predict the variable influencing the crossing time High/Low.

Results:
According to the analysis, females making path changes and an increase in stage number show a higher road crossing time for pedestrians. Also, the absence of motor vehicles results in a higher road crossing time for pedestrians. The prediction accuracy of the model is 58.2%, and a variance of 6% shows a lesser degree of spread in the dataset.

Conclusion:
The inference from the study is that the crossing time of path-changing pedestrians is more than straight-moving pedestrians. Thus, an increase in road crossing time decreases the safety of pedestrians by increasing the exposure rate while crossing the road. So, the probability of safety risk is high when they practice irregular road crossing patterns.
The Effects of Different Temperaments on Vascular Parameters: A Pilot
Crossover Randomized Controlled Trial
Authors: Zakerian Mohsen , Roudi Fatemeh , Rezvani Reza , Jarahi Lida , Yousefi Mahdi , Anoushirvani Majid , Sahebkar Amirhossein , Motavasselian Malihe 
Published: March 2023

Background:
According to the Persian Medicine (PM) point of view, the function of
the cardiovascular system and the risk of cardiovascular events would be different between subjects
having warm and cold temperaments. Moreover, different foods in terms of temperament
may lead to different acute and chronic effects on the body.

Objectives:
We investigated the postprandial effects of PM-based warm and cold test meals on arterial
stiffness indices in healthy men with warm and cold temperaments.

Methods:
Twenty-one eligible warm or cold temperament subjects with a similar range of age,
weight, and heights were enrolled in this pilot cross-over randomized controlled trial study during
February- October 2020. Two test meals (cold and warm PM-based temperament foods)
were designed as different interventions. Pulse wave velocity (PWV) and pulse wave analysis
(PWA) was obtained at the baseline state (following 12 hours fasting), 0.5, 2, and 4 hours after
the test meal consumption during each test day.

Results:
Warm temperament participants had higher values of lean body mass, total body water,
and protein content (P = 0.03, 0.02, and 0.02, respectively). Cold temperament individuals had
higher aortic heart rate (HR) following 12 hours of fasting (P <0.001). On the other hand, the
augmentation pressure (AP) of warm temperament individuals was higher than the colds (
P = < 0.001).

Conclusion:
According to the results of the present study, although warm temperament individuals
could have higher arterial stiffness at the fasting state, arterial stiffness indices had a greater
reduction following warm-temperament meal intake compared to cold-temperament meal.

Trial Registration number::
International Clinical Trials Registry Platform IRCT20200417
047105N1 (Where the full trial protocol can be accessed).
Using Digital Measurement–Based Care for the Treatment of Anxiety and Depression in Children and Adolescents: Observational Retrospective Analysis of Bend Health Data
Authors: Huffman Landry Goodgame , Lawrence-Sidebottom Darian , Huberty Jennifer , Roots Monika , Roots Kurt , Parikh Amit , Guerra Rachael , Weiser Jaclyn 
Published: March 2023

Background
A growing body of evidence supports the efficacy of measurement-based care (MBC) for children and adolescents experiencing mental health concerns, particularly anxiety and depression. In recent years, MBC has increasingly transitioned to web-based spaces in the form of digital mental health interventions (DMHIs), which render high-quality mental health care more accessible nationwide. Although extant research is promising, the emergence of MBC DMHIs means that much is unknown regarding their effectiveness as a treatment for anxiety and depression, particularly among children and adolescents.

Objective
This study uses preliminary data from children and adolescents participating in an MBC DMHI administered by Bend Health Inc, a mental health care provider that uses a collaborative care model to assess changes in anxiety and depressive symptoms during participation in the MBC DMHI.

Methods
Caregivers of children and adolescents participating in Bend Health Inc for anxiety or depressive symptoms reported measures of their children’s symptoms every 30 days throughout the duration of participation in Bend Health Inc. Data from 114 children (age 6-12 years) and adolescents (age 13-17 years) were used for the analyses (anxiety symptom group: n=98, depressive symptom group: n=61).

Results
Among children and adolescents participating in care with Bend Health Inc, 73% (72/98) exhibited improvements in anxiety symptoms and 73% (44/61) exhibited improvement in depressive symptoms, as indicated by either a decrease in symptom severity or screening out of completing the complete assessment. Among those with complete assessment data, group-level anxiety symptom T-scores exhibited a moderate decrease of 4.69 points (P=.002) from the first to the last assessment. However, members’ depressive symptom T-scores remained largely stable throughout their involvement.

Conclusions
As increasing numbers of young people and families seek DMHIs over traditional mental health treatments due to their accessibility and affordability, this study offers promising early evidence that youth anxiety symptoms decrease during involvement in an MBC DMHI such as Bend Health Inc. However, further analyses with enhanced longitudinal symptom measures are necessary to determine whether depressive symptoms show similar improvements among those involved in Bend Health Inc.
Analysis of the Effect of Occupational Safety and Health (OSH) Culture on Implementing OSH Awareness: A Case Study
Authors: Pratiwi Indah , Ivanovic Yusakh 
Published: March 2023

Occupational Safety and Health (OSH) culture among students has not become a full awareness that is applied in everyday life in college. This study aims to identify, test, and analyze how much OSH culture influences implementing OSH awareness for students. The research was conducted on Industrial Engineering students at Universitas Muhammadiyah Surakarta (IE UMS) as many as 120 respondents from the class of 2016 to 2019 filled out a questionnaire about OSH culture. The method used in this study is the analysis approach of Structural Equation Modeling (SEM) variance-based or so-called Partial Least Square (PLS-SEM). The variables in the OSH culture are four independent variables, namely: individual, organizational, occupational, and environmental with 18 sub-variables. Meanwhile, one dependent variable, awareness, consists of six sub-dependent variables. It was found that environmental, organizational, and occupational factors on awareness level significantly affect implementing OSH culture, and individual factors have no significant effect on the awareness level of implementing OSH culture. Thus, an improvement strategy is obtained by increasing environmental, organizational, and occupational preferences to maximize the implementation of OSH culture.
Original article Forecasting trends in the development of time series by estimating the Hodges-Lehman median
Authors: Misyura V. V. , Misyura E. V. 
Published: March 2023

Introduction. The lack of stationarity in the time series’ development, small samples, the outliers presence, jumps do not allow to find estimates of model parameters that have good properties of statistical estimates and, as a result, to find reliable forecasts, both in the development trend of the process and in its numerical expression. The means to solve these problems is the use of ordinal or robust statistics. Scientific monographs and special chapters in books on mathematical statistics contain a deep and extensive theory on the study of the properties of ordinal statistics, which are the justification for their application in forecasting methods. The aim of the work is to develop and verify method for obtaining one-step forecasts of trends in the development of time series based on stable statistical estimates.Materials and methods. The article presents the results of the development of a method for obtaining one-step forecasts of trends in the development of time series based on the construction of confidence intervals of a selective stable HodgesLehman estimate based on Walsh averages. In particular, the Hodges-Lehman median is used to solve the problem of small samples obtained during the procedure of shifting the time series window. The proposed method is considered in detail in the article: the basic definitions, the theoretical justification of the method, calculation formulas, a detailed description of the algorithm, formulas for calculating the quality metric of forecasts are given.The results of the study. The method was implemented in computational experiment using the example of forecasting the Urals crude oil’s spot price. The article presents the computational experiment’s results. The parameters of the proposed method can be configured to obtain reliable one-step forecasts.Discussion and conclusions. The method proposed in the article has shown its effectiveness on experimental data and can be used as an independent method for constructing one-step forecasts of trends in the development of time series. Further development of the method involves the improvement of computational procedures, verification of the method in case of jumps in the dynamics of the time series.
The Dependence of the Learning Efficiency on the Academic Motivation of Adults Studying in the Conditions of Extended Education
Authors: Zvezdina G. P. 
Published: March 2023

Introduction. The relevance of studying the designated topic lies in the lack of knowledge of the connection between motivation and learning effectiveness. The problem of studying motivation is caused by the versatility and complexity of quantitative measurement.Purpose. The study aims to investigate the relationship between motivation to learn online and its effectiveness in additional education among adult learners.Materials and Methods. The sample group consisted of 60 online school students. The following methodological tools were used: the Academic Motivation Scales by Gordeeva, Sychev, and Osin; the Motivation for Professional Development Test by Zamfir and Rean; the Motives for Choosing a Profession by Grinshpun; The author’s Efficiency of Extended Education Questionnaire.Results. It is established that the dominant educational motives of adult students in the conditions of additional education are the motives of self-development, self-esteem, and achievement. Direct correlations between motivation indicators and learning effectiveness are revealed: Cognitive motivation has a strong direct relationship with study intensity (r = 0.853), with changes in knowledge level (r =0.898) and with the overall effectiveness of learning (r =0.838). Motivation for achievement was found to be associated with changes in behaviour (r = 0.825), a change in income level (0.756) and general progress (0.835).Discussion and Conclusion. The empirical data analysis indicates high values of participation and changes in the behaviour of adult learners, which indicates that the effectiveness of learning is expressed in subjective and objective factors. Based on the results obtained, recommendations are made to improve the effectiveness of adult education under conditions of additional education. In conclusion, it is emphasized that high interest in knowledge affects the effectiveness of adult learning, and motivation for self-development and achievement leads to behaviour change.
EFFECTS OF SCAFFOLDING STRATEGIES INSTRUCTION ON EFL STUDENTS’ WRITING ACHIEVEMENT AND PERCEPTIONS
Authors: Hassen Seyidu Kemal , Adugna Ebabu Tefera , Bogale Yenus Nurie 
Published: March 2023

This quasi-experimental study examined the effects of scaffolding strategies instruction on students writing achievement and perceptions in an Ethiopian EFL setting. From the total of 9 sections in Grade 10, two were randomly identified as comparison and experimental groups. 48 students participated in each group, and data were collected through pre-post writing tests and follow-up questionnaires. Results from paired samples t-test revealed that the treatment had a significant impact on improving students’ writing achievement in each aspect of writing except for mechanics, as indicated by p=.001, pα, at α=0.05 for each aspect of writing except for mechanics, use that had p=.-307, pα. The findings implied that the treatment enabled experimental group participants to improve each aspect of writing skills except mechanics use. Analysis of the questionnaire data further demonstrated that the experimental group participants had positive perceptions towards the value of the scaffolding strategies instruction for improving their writing skills.