bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virological failure of antiretroviral therapy and associated social and clinical factors in children and adolescents living with HIV
Authors: Sambyalova A. Yu. , Bairova T. A. , Manaenkova T. L. , Belskikh A. V. , Plotnikova Yu. K. , Rychkov L. V. 
Published: January 2023

According to the World Health Organization, sustained virological suppression of 90 % should be achieved among children and adolescents living with HIV / AIDS, which makes it important to assess the prevalence of virological failure of antiretroviral therapy. The aim of this study was to determine the prevalence of virological failure and the clinical factors associated with it, as well as therapeutic drug monitoring in groups divided by the viral load level among children and adolescents with HIV. Materials and Methods: A retrospective analysis of the medical records of 184 children and adolescents receiving antiretroviral therapy and registered at the Irkutsk Regional Center for the Prevention and Control of AIDS and Infectious Diseases, Irkutsk, was carried out. The study included 172 children aged 1-18 years with perinatal HIV infection. Patients were divided into groups depending on the level of viral load: group 1 – 21 patients with viral load > 1000 copies/ml of plasma, group 2 – 42 patients with viral load 50– 1000 copies/ml of plasma, group 3 – 109 patients with undetectable viral load (< 50 copies/ml). All patients underwent standard tests in accordance with clinical guidelines for the treatment of HIV infection in children, as well as therapeutic drug monitoring. Results. Against the background of ongoing antiretroviral therapy, a significant number of patients 21 / 172 (12,2 %) experienced virological failure. The proportion of children and adolescents with incomplete suppression of HIV replication is 42 / 172 (24,4 %). Statistically significant differences were obtained by changing the ART regimen (p = 0,031). In the first group, the proportion of patients who changed the therapy regimen is 7 / 21 (33,3 %), which is two times less than in the group with a zero viral load of 70 / 109 (64,2 %). There are differences in the proportion of children and adolescents with zero concentrations of ritonavir and lopinavir (p = 0,020 and p = 0,012) in the three compared groups. The distribution of patients with zero concentrations was as follows: for ritonavir in the first group 3 / 17 (17,6 %), in the second – 8/37 (21,6 %), in the third group – 4/80 (5 %); for lopinavir – 4/17 (23,5 %), 6/36 (16,7 %), 3/80 (3,8 %), respectively. Conclusion. This study demonstrates that the prevalence of virological failure among children and adolescents receiving ART remains high. To achieve sustained virological suppression in children and adolescents taking a protease inhibitor regimen, adherence to therapy must be increased. As one of the methods for assessing adherence, therapeutic drug monitoring can be used.
Real-world effectiveness and safety of pan-genotypic antiviral therapy for chronic HCV-infection: data from three clinical centers in St. Petersburg
Authors: Gusev D. A. , Zhdanov K. V. , Kozlov K. V. , Vinogradova T. N. , Kopot M. Yu. , Sukachev V. S. , Zhabrov S. S. , Kizhlo S. N. , Romanova S. Yu. , Musatov V. B. , Tyurenkova N. V. , Vlasova Yu. A. , Kolpashchikova E. Yu. , Fedorov P. N. , Minin P. V. , Korneeva T. S. 
Published: January 2023

The aim of the analysis was to describe the results of administration of pan-genotype antiviral therapy (glecaprevir / pibrentasvir, GLE / PIB) in real-world setting in three clinical centers in St. Petersburg within the city program for the treatment of chronic hepatitis C. Materials and methods. A retrospective analysis of the GLE / PIB usage of in the period from 2019 to 2022 within the city program for the treatment of chronic hepatitis C in St. Petersburg was carried out. Results. The analysis included 464 patients treated in three clinical centers of St. Petersburg: St. Petersburg State Medical Institution “Clinical Infectious Diseases Hospital named after S. P. Botkin”, St. Petersburg State Medical Institution “Center for the Prevention and Control of AIDS and Infectious Diseases” and the Clinic of Infectious Diseases of the Military Medical Academy named after S. M.Kirov”. Overall 452 out of 464 patients (97 %) achieved SVR12. According to the duration of treatment, SVR12 rates were the following: 8 weeks – 97.7 % (419 / 429), 12 weeks – 92.9 % (26 / 28) and 16 weeks – 100 % (7 / 7). The effectiveness according to fibrosis stage was as follows: F0 – 97 % (142 / 146), F1 – 100 % (74 / 74), F2 – 100 % (59 / 59), F3 – 98 % (57 / 58), F4 (CP-A, B) – 94 % (118 / 125). SVR12 according to HCV genotypes and subtypes was the following: genotype 1b – 100 % (63 / 63), genotype 1a – 91 % (21 / 23), genotype 1 unspecified – 100 % (23 / 23), genotype 2 – 98 % (50 / 51), genotype 3 – 97 % (292 / 301). In patients with an indeterminate genotype, the efficacy was 100 % (7 / 7). Antiviral therapy was well tolerated, there were no cases of discontinuation of therapy, as well as cases of the development of serious adverse events. Conclusion. GLE / PIB has demonstrated high effectiveness in the real-world setting in patients infected with prevalent genotypes of HCV, including those with genotype 3 and compensated liver cirrhosis. The results of our analysis fully correspond to the data obtained earlier in clinical trials andreal-world setting.
Growth Dinamics on the Skin and the Coat in Normandian and Simmental Cattle During Adaptation to the Farming Technology in Southwestern Part of Bulgaria
Authors: Markov Nikolay , Stoycheva Svetoslava , Bancheva Tsvetomira , Mickov Ljupcho , Atanasov Branko , Esmerov Igor , Adamov Nikola 
Published: January 2023

Abstract
The aim of the present study was to identify the adaptability of Normandy cows raised in a loose system to the climatic and technological conditions and to compare their adaptability with already acclimatized Simmental cows in one farm in Southwestern Bulgaria. Total of 20 cows at same age (II – IV lactation) and same body weight (630-660 kg) from both breeds were classified into 2 groups (each having 10 cows) and subjected to skin thickness measurement, fibers total weight determination and fiber categorization during the winter and summer season. The results have shown that during the winter season, the Normandy breed had significantly higher skin thickness at the elbow compared to the Simmental breed, whereas no differences were observed in the skin thickness between both breeds either at the neck or at the middle of the last rib. During the summer season, the differences on the skin thickness compared to the Simmental breed were observed at the neck (p<0.05), whilst at the elbow and at the middle of the last rib no differences were recorded (p>0.05). During the winter seasons, the coat of Normandy cows contained more soft fibers in comparison to the Simmentals cows. Furthermore, the changes in the observed parameters, influenced by climatic conditions showed similar pattern in both breeds. It can be concluded that the two breeds have emphasized their genetic potential and have a good adaptability to the temperate continental climate of the region.
Pharmacokinetic Criteria of Ketoprofen and its Cyclooxygenase-2 Inhibition in Mice: Influence of Xylazine Administration
Authors: Khalil Khalil Abdullah , Mousa Yaareb Jaafer , Alzubaidy Muna Hazim 
Published: January 2023

Abstract
The objective of this study was to examine the effect of ketoprofen with or without combination with xylazine on the level of cyclooxygenase-2 in mice. The intraperitoneal (i.p.) dose of ketoprofen and xylazine that caused an analgesic response in half of the mouse population was 1.26 mg/kg and 6.63 mg/kg, respectively. Serum cyclooxygenase-2 concentration (activity) in the control mice was 16.94 ng/ml. The ketoprofen-treated group (2.52 mg/kg, i.p.) decreased the cyclooxygenase-2 concentration by 58% (7.16 ng/ml). The combined ketoprofen and xylazine treatment (13.26 mg/kg, i.p.) decreased the cyclooxygenase-2 by 94% (0.98 ng/ml). The ketoprofen plasma concentration in the combined treatment group was significantly higher compared to the ketoprofen treatment group. Ketoprofen plasma concentrations measured at 0.25, 0.5, 1, 2, 4, and 24 hours were 19.07, 18.94, 14.66, 6.53, 5.44, and 5.54 µg/ml, respectively. Plasma concentrations of ketoprofen and xylazine were raised to 28.74, 29.74, 15.32, 13.04, 14.64, and 11.95 µg/ml or by 51%, 56%, 5%, 100%, 169%, and 116%, respectively. Ketoprofen pharmacokinetic variables were increased (AUC0-∞ (515%), AUMC0-∞ (2389%), MRT (305%), t1/2β (375%), Tmax (100%), and Cmax (55%)), while other values were decreased (Kel (79%), Vss (25%), and Cl (88%)). Our findings suggested a synergistic interaction between ketoprofen and xylazine on the level of cyclooxygenase-2 (pharmacodynamic interaction) which was exerted by modification of the ketoprofen pharmacokinetic properties in mice.
The Simplest Models of the Macroeconomics Dynamics in a Composition with the Principle of the Subjective Entropy Maximum
Authors: Kasianov Vladimir Aleksandrovich , Goncharenko Andriy Viktorovich 
Published: January 2023

Abstract
This paper proposes a solution to a certain macroeconomic model. A multi-alternative problem of aviation transportation optimal organisation in conditions of uncertainty of the subjective preference functions is considered. Conditional optimisation of the objective functional containing the entropy of the individuals’ operational effectiveness functions preferences is carried out in the framework of the simplest macroeconomic problem. The principle of the Solow and Cobb–Douglas models, similar to the approach adopted for the estimation of economic growth, is modified with the subjective entropy maximum principle. The advantages of the described optimisation approach are demonstrated in the generalised terms of the operational effectiveness functions for aviation transportation organisation.
Optimisation of a Nacelle Electro-Thermal Ice Protection System for Icing Wind Tunnel Testing
Authors: Gallia Mariachiara , Carnemolla Alessandro , Premazzi Marco , Guardone Alberto 
Published: January 2023

Abstract
Aircraft are equipped with ice protection systems (IPS), to avoid, delay or remove ice accretion. Two widely used technologies are the thermo-pneumatic IPS and the electro-thermal IPS (ETIPS). Thermo-pneumatic IPS requires air extraction from the engine negatively affecting its performances. Moreover, in the context of green aviation, aircraft manufacturers are moving towards hybrid or fully electric aircraft requiring all electric on-board systems. In this work, an ETIPS has been designed and optimised to replace the nacelle pneumatic-thermal system. The aim is to minimise the power consumption while assuring limited or null ice formation and that the surface temperature remains between acceptable bounds to avoid material degradation. The design parameters were the length and heat flux of each heater. Runback ice formations and surface temperature were assessed by means of the in-house developed PoliMIce framework. The optimisation was performed using a genetic algorithm, and the constraints were handled through a linear penalty method. The optimal configuration required 33% less power with respect to the previously installed thermo-pneumatic IPS. Furthermore, engine performance is not affected in the case of the ETIPS. This energy saving resulted in an estimated reduction of specific fuel consumption of 3%, when operating the IPS in anti-icing mode.
The role of self-congruity in the relationship between destination brand personality and revisit intention
Authors: Kurnia Dede , Rahayu Agus , Hendrayati Heny 
Published: January 2023

The purpose of this study was to explore and analyze the direct influence of destination brand personality and the intermediary effect of self-congruity on the influence of destination brand personality on revisit intentions by including gender and emotional experience as moderator variables. This research were using a quantitative approach with an explanatory survey method. In this research, we used a questionnaire as a data collection tool while determining the sample. It also used a non-probability sampling technique to obtain 100 visitors to the Sukahaji Waterboom Tourism Destination. It used Conditional Process Analysis (CPA) with the Regression approach and used Software Macro Process by Hayes as the data analysis technique. The goals of this paperindicate that destination brand personality has no direct effect on revisit intention. It shows that the effect of destination brand personality on revisit intention is transmitted by self-congruity. The results of the subsequent analysis show that emotional experience and gender do not moderate the effect of destination brand personality and self-congruity on revisit intention.
Strategic Indicators for Strategic Intervention in Sports Facilities Management Performance in Malaysia
Authors: Hassin Mohd Asrul , Zaidi Mohd Azian , Ali Irwan Mohammad 
Published: January 2023

Objective –The sports facilities provided are not fully utilized, misused, unprotected, and not maintained by the responsible parties. Most studies indicate sports facilities face numerous facilities management (FM) issues owing to weakness of current operating systems such as financial factor, lack of qualify staff, efficient and quality management operations, optimisation of operation, and safety issues. The purpose of this paper is to examine the strategic indicators for strategic intervention for improving the performance of sports facilities management in Malaysia by initially identifying what the critical considerations. Methodology. The data for this preliminary study was obtained from random samples of 44 respondents involving FM representative from various stadium in Malaysia. The data will initially analysed using SPSS statistical software for factor analysis. The reliability and validity data of the instruments were assessed by experts from academia and the industry. The reliability and validity data of the instruments were assessed by experts from academia and the industry.
Findings research contributes to the existing body of knowledge on FM by identifying the relationship between FM performance and strategic intervention.
Implications Finally, in order to develop strategic intervention conceptual model toward sports facilities management performance will to be involved in all the strategy phases of the organisation.
An Initial Study of Disclosures Related to Responsible Investing Implementation: A South African Perspective
Authors: Jacobson Lori , Varachia Zakiyyah , Van Zijl Wayne 
Published: January 2023

Purpose: Financial institutions (FIs) such as banks, insurance companies and pension funds have a significant impact on the environment through the financing they provide. Mining and oil and gas companies receive funding and use this for different projects which may have environmental consequences. This study examines the extent to which both the grantor and the receiver of finance identify and apply responsible investment (RI) practices when making investment decisions
Design/methodology/approach: A detailed literature review was used to construct a disclosure checklist to assess the implementation of RI principles. The population is all companies listed in the financial services, banks, mining and oil and gas sectors of the Johannesburg Stock Exchange (JSE), who had published integrated reports.
Findings: The results of this research indicate that the extent of RI disclosure in FIs in South Africa is limited. The extent of RI disclosure for the mining and oil and gas companies is stronger than for FI’s.
Originality/value: At present, there are no studies which have investigated the disclosure of RI principles applied in South Africa. This study constructed a RI disclosure checklist, drawing on the principles of RI to understand the implementation of RI in South Africa.
Bunga Edelweis Sebagai Objek penciptaan
Authors: Oktaviani Yori , Hamzah Hamzah , Gani Maulid Hariri 
Published: January 2023

Penciptaan karya Tugas Akhir ini didasari karena pengkarya ingin meluapkan rasa prihatin dan sedih terhadap kondisi dan keadaan dari populasi dan habitat asli bunga edelweis pada saat ini. Rasa yang dihadirkan pada karya seni lukis bunga edelweis ini disampaikan dengan karya bergaya dekoratif, yang bertujuan supaya rasa prihatin dan dan sedih itu dapat tersampaikan, dengan berusaha menampilkan visual objek dengan hiasan. Metode penciptaan yang dilakukan terdiri dari persiapan yang mengumpulkan data, perancangan dengan menuangkan ide dari hasil yang didapatkan. Perwujudan menghadirkan proses konsep dari awal rancangan penyajian karya setelah diproses. Proses perwujudan selesai dilakukan proses finishing yaitu pembingkaian karya. Dalam penciptaan karya seni lukis, bentuk visual utama yang dihadirkan yaitu bunga edelweis, dan objek pendukung lainnya, serta di hias dengan titik-titik dan kontur pada bagian background. Masing- masing karya memiliki perbedaan baik bentuk tata letak visual dll, sebagai media untuk mengungkapkan ekspresi dari rasa prihatin dan sedih dari diri pengkarya sendiri terhadap kondisi dan keadaan dari populasi dan habitat asli dari bunga edelweis.
Assessment of a Decision-Making Model for Monitoring the Success of a Project for Smart Buildings
Authors: Amhaimedi Serag , Naimi Sepanta , Alsallami Sura 
Published: January 2023

Objective: To express the usage of intelligent concepts in the architectural building construction field that are primarily concerned with reducing building energy use. Improved energy-saving methods and the use of environmentally friendly design principles are essential in this field. This type of managerial decision-making is necessary for the success of these types of projects. Methods: monitoring the performance of intelligent buildings use the cost variance (CV) and schedule variation as standard metrics to track the progress of a project based on the save energy concept. Also, this research conducted a comparative study on Building Information Modelling (BIM) and (MCDM) decision-making limitations as presented in the article. Analysis: the conventional technique, on the other hand, is unable to offer data on variance from typical performance levels. The main point based on Delphi results of construction cost variables has been observed 19 effective factors. Finding and Novelty: The RII observed that the most effective aspects of an intelligent building are the number of floors in the building, the kind of structural design, and the size of the shadow cast on the surface of the building. The Multi-Criteria Decision Maker (MCDM) observed significant differences in planned value (PV) and actual value (AC) results. In addition, as a result of the current approach, it is possible to track project costs and timelines more precisely. Doi: 10.28991/CEJ-2023-09-01-010 Full Text: PDF
Modelling the Implications of Delayed Payments on Contractors’ Cashflows on Infrastructure Projects
Authors: Chadee Aaron , Ali Hanna , Gallage Sihara , Rathnayake Upaka 
Published: January 2023

The consideration of payments to contractors is not only a legal obligation but a necessity for assuring the continuity and completion of a construction project. However, consistent payments to facilitate project cash flows are uncommon in the construction industry. Within the context of a small island developing state, this paper aims to uncover leading risks factors the contributing to implications of delayed payments, on contractors’ cash flows and uncover any causalities and effects on relationships among these factors. A two-tiered quantitative approach was adopted. Firstly, a compiled list of delay factors was collated from the literature review. Semi-structured interviews were conducted with experienced construction professionals to determine the factors’ relevance and applicability in Trinidad and Tobago. A closed-ended survey questionnaire was subsequently developed and administered to primary construction stakeholders. Secondly, the responses obtained were collated, validated, and ranked using the relative importance index. A confirmatory factor analysis (CFA) was carried out using SPSS, and thereafter, SPSS Amos was used to determine the best-fit Structural Equation Model (SEM). The results strongly indicate that the issue of delayed payments is very prevalent within public sector projects. Unstable political climates and the delay in employers’ issuance of variation orders were found to be the main causes of delayed payments within the industry. Delays in sub-contractor and supplier payments as well as an increase in the contractor’s debt are the leading effects of delayed payments on the contractor’s cash flows. Based on these findings, a risk response framework was outlined to assist small to medium-contracting enterprises cope with payment delays, both locally and internationally. This research contributes to the advancement of construction management knowledge by informing construction professionals and policy makers of the implications of delaying approved payments, the consequential causes and effects, and a risk response technique to mitigate the negative effects on contractors’ cash flows. Doi: 10.28991/CEJ-2023-09-01-05 Full Text: PDF
TAHAPAN EMBRIOGENESIS TELUR IKAN GURAMI (OSPHRONEMUS GOURAMY) PADA SUHU YANG BERBEDA SELAMA 48 JAM
Authors: Hadi Samsul , Junaidi Muhammad , Lestari Dewi Putri 
Published: January 2023

Ikan gurame (Osphronemus gouramy) merupakan salah satu jenis ikan air tawar yang memiliki nilai ekonomis tinggi dan banyak digemari oleh masyarakat luas. Permasalahan yang di hadapi dalam penetasan telur ikan gurame yaitu daya tetas telur yang masih rendah dan tingkat kelulushidupan yang masih rendah. Pada fase ini kondisinya masih rentan terhadap perubahan lingkungan. Suhu adalah hal yang perlu diperhatikan dalam penetasan telur ikan gurame, oleh karena itu perlu dilakukan manipulasi suhu dalam wadah agar suhu lebih konstan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh suhu terhadap penetasan telur dan pertumbuhan larva ikan gurame (O. gouramy). Bahan uji yang digunakan adalah telur ikan gurame (O. gouramy) dengan total telur yang digunakan sebanyak 900 butir. Penelitian ini menggunakan metode eksperimental dengan Rancangan Acak Lengkap 5 perlakuan 3 ulangan. Perlakuan dalam penelitian ini: perlakuan suhu P1 (28oC), P2 (29oC), P3 (30oC), P4 (31oC) dan P5 (32)oC. Data yang diamati meliputi survival rate, hatching rate, lama penetasan, panjang mutlak, dan spesifik growt rate. Hasil penelitian menunjukan bahwa perbedaan suhu berpengaruh nyata terhadap lama penetasan telur, panjang mutlak,kelulushidupan dan spesifik growt rate., sedangkan tidak berpengaruh nyata terhadap daya tetas telur ikan gurame (O. gouramy). Perlakuan E 32oC adalah perlakuan yang terbaik yang menghasilkan penetasan 22 jam, daya tetas telur 96,67% kelulushidupan 91,35%, pertumbuhan panjang mutlak 1,47 cm dan SGR 4,42%.