bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatics analyses of potentially common pathogenic networks for primary Sjogren’s syndrome complicated with acute myocardial infarction
Authors: Hou Qingbin , Jiang JINping , Na kun , Zhang Xiaolin , Liu Dan , Jing Quanmin , Yan Chenghui , Han Yaling 
Published: July 2023

Abstract
Both primary Sjogren’s syndrome (pSS) and acute myocardial infarction (AMI) are intricately linked to one another. However, their common mechanism is not fully understood. Herein, we examined the underlying network of molecular action associated with the development of this complication.datasets were downloaded from the GEO database, We performed enrichment and protein–protein interaction analyses and screened key genes. To confirm the diagnostic performance for these hub genes, we used external datasets. Transcription factor and microRNA regulatory networks were constructed for the validated hub genes. Finally, drug prediction and molecular docking validation were performed.We identified 51 commonDEGs, many of which were enriched in terms of Inflammation and immune response. five DEGs were found as key hub genes ( IGSF6、MMP9、S100A8, MNDA, and NCF2). They had high diagnostic performance in external datasets. Functional enrichment of these five hub genes showed that they were associated with the adaptive immune response.The Type 1 T helper cell showed the most association among all cell types related to AMI and pSS. we identified 27 common TFs and 20 identical TF-miRNAs. The drugs including Benzo、dexamethasone and NADP were predicted as potential therapeutic agents. Herein, we revealed common networks involving pSS and AMI etiologies. Knowledge of these networks and hub genes can enhance research into their associated mechanism and development of future robust therapy.
Perceptions of Experienced Primary Care Physicians on Telemedicine: Treatment Convenience affects more than Treatment Quality - A Questionnaire-based Study
Authors: Cohen Avivit Golan , Tal Yossi , Hersh Daniel , Vinker Shlomo , Merzon Eugene , Green Ilan , Israel Ariel , Tuval Atalia 
Published: July 2023

Abstract
Background: Telemedicine can potentially enhance healthcare delivery and improve patient outcomes. Previous studies have highlighted the crucial relationship between physicians’ attitudes and the extent of telemedicine implementation. However, despite significant efforts, especially during the Covid-19 pandemic, the implementation of telemedicine in primary care systems has not met expectations.
Objective: This study aimed to investigate how primary care physicians’ attitudes toward telemedicine are influenced by the perceived opportunities and risks associated with its use after gaining firsthand experience with the service.
Methods: A cross-sectional study was conducted using validated online self-reported questionnaires, distributed to all primary care physicians providing telemedicine consultations for at least three months in a large health maintenance organization (HMO) in Israel. Descriptive statistics were employed to summarize the study variables. Spearman’s correlation coefficient was used to assess associations between continuous variables. Independent sample t-tests were used to compare continuous variables across different categories. All statistical analyses were two-sided; a p-value < 0.05 was considered statistically significant.
Results: 128 (20%) physicians completed the questionnaire. The perceived strength of the identified opportunities outweighed that of the risks. Furthermore, the importance assigned to issues related to enhancing patient service was greater than that given to aspects associated with improving treatment.
Conclusion: Primary care physicians recognize telemedicine’s potential opportunities, particularly in enhancing patient service. Policymakers aiming to expand the utilization of telemedicine should adopt a comprehensive approach and implement changes that address the needs and concerns of physicians and patients alike.
An Improved DV-Hop Localization Algorithm based on Human Conception Optimization with Time Varying Acceleration Coefficients for Wireless Sensor Network
Authors: Panda Subrat Kumar , Acharya Debasis , Das Dushmanta Kumar , Rajagopal R Kumar 
Published: July 2023

Abstract
Wireless Sensor Network (WSN) is widely used in a variety of practical applications. WSN may be used to sense objects, gather information, analyze it, and then transmit it again. The significance of optimization techniques is crucial for the accurate and reliable estimation of the sensor nodes’ location. The positioning accuracy of traditional DV-Hop localization algorithm is not entirely satisfactory instead of it is quite simple, stabilized, feasible, and requires less hardware. Thus to enhance the positioning accuracy without increasing the hardware cost of a sensor node, this article provides an improved DV-Hop localization algorithm using Human Conception Optimization (HCO). The proposed method adds a parameter to alter the anchor nodes' hop size. Furthermore, it is analyzed with traditional DV-Hop, IDV-Hop algorithm, DV-Hop based PSO, and DV-Hop based CTO. The simulation results support the conclusion that, the proposed algorithm performs better than the competing algorithms by minimizing the localization error, localization error variance, and the localization accuracy with varying the number of anchor nodes, total number of nodes, and the communication range.
Assessing the Importance of Anthropometric, Physiological, Physical, and Psychological Fitness Indicators on the Performance of Elite Shooters Using a Talent Identification Approach
Authors: Takhtaei Mehdi , Shakibaee Abolfazl , Hosseini Seyed Morteza 
Published: July 2023

Abstract
Background: Performance in shooting sports is influenced by various factors. Examining different dimensions can help in identifying talent in this sport and lead to a better estimate of performance. The purpose of this research was to determine the importance of anthropometric, physiological, physical, and psychological indicators on the performance of elite shooters.
Method: This study employed a correlation design as a predictive and applied research method. Participants were selected from among 20 to 40-year-old male elite shooters from the Islamic Republic of Iran who had at least ten years of air rifle shooting experience and were members of the national shooting teams. A targeted sampling approach was used, and 47 shooters were selected. Participants completed a 30-trial test, with their scores used as a measure of success. Anthropometric, physiological, physical, and psychological fitness evaluations were conducted, and statistical tests were used to identify and prioritize the factors that were most effective in the obtained scores.
Results: The findings of this study suggest that heart rate per minute, reaction time, interpersonal skills, strength, central stability, emotion control, focus recovery, self-talk, and relaxation were the most important indicators in the shooter's performance.
Conclusion: This study highlights the multifaceted nature of shooter performance and identifies specific indicators that can be targeted for improvement. By addressing these factors, coaches, trainers, and athletes can work to optimize shooter performance and achieve better results in shooting sports.
Evaluation Of Depression, Self-Esteem, Anxiety And Dermatological Quality Of Life Index In Adolescent Acne Patients: A case-control study
Authors: Kazan Didem , İnci Burcu Bahar , Ilchan Selin , Özkoca Defne 
Published: July 2023

Abstract
Background/ objective: Acne vulgaris is commonly seen in adolescents. It could affect the psychology of the patients. In this study, we aimed to evaluate the depression, self-esteem, anxiety, and dermatological quality of life indexes of adolescent patients with AV.
Method: One hundred and sixty patients, aged between 10 and 19 years, with AV; and 100 healthy controls were included in the study. Acne severities of the patients were evaluated via the Global acne grading system by dermatologists. Reynolds adolescents depression scale, Beck adolescents anxiety scale, Coopersmith self-esteem investigatory Scale, and children life quality index were completed by participants.
Results: The RADS and BAAS scores of the study group were significantly higher than controls (respectively; 27.5% & %12.5%, p=0.003, 80% & 64% p=0.001). The percentage of patients with CSES scores below 20 in the study group was significantly higher than in the control group (p=0.001) The higher RADS and BAAS scores were associated with the higher CDLQI score ( p=0.001, p=0.001; respectively). The higher CSES scores were associated with lower CDLQI scores (p=0.001).
Conclusion: Acne vulgaris affects the prevalence of depression, anxiety, and lower self-esteem in adolescent patients. Dermatologists should assess the psychology of the patients and if necessary, psychiatric evaluation should be provided.
Multimodality imaging for diagnosis, risk stratification and treatment monitoring of cardiac sarcoidosis
Authors: Young Kathleen A. , Raoult Tristan , Leccisotti Lucia , Gerber Bernhard , Chareonthaitawee Panithaya , Gheysens Olivier 
Published: July 2023

Abstract
Cardiac sarcoidosis (CS), with either extracardiac involvement or in isolation, is increasingly recognized. Complications from cardiac involvement are the leading cause of death in patients with sarcoidosis, rendering early detection extremely important given the significant therapeutic and prognostic implications. However, the diagnosis of CS remains challenging due to the lack of a reliable gold standard, largely due to the low sensitivity of traditional endomyocardial biopsy and patchy myocardial involvement. Recent advances in cardiac imaging with [18F] fluoro-deoxyglucose positron emission tomography-computed tomography ([18F]FDG PET/CT) and cardiac magnetic resonance (CMR) have provided unprecedented information on the prevalence of CS and have revolutionized the diagnosis and management of CS patients. Abnormal PET/CMR findings are now major criteria in societal guidelines to establish a probabilistic diagnosis of CS. This review provides a brief introduction to CS and a summary of current diagnostic criteria, followed by a review on the current use and strengths of PET/CT and CMR for diagnosis, risk stratification and treatment response evaluation. CMR is the most robust technique to assess left ventricular function, to detect myocardial fibrosis and differentiate CS from other cardiomyopathies and has an excellent negative predictive value. On the other hand, [18F]FDG PET/CT is the modality of choice to assess active myocardial inflammation which may be amenable to immunosuppressive treatment as well as to detect extracardiac involvement, to identify potential biopsy sites and to monitor treatment efficacy. Understanding the complementary value of both techniques is crucial to the optimal utilization of advanced imaging in patients with CS. Lastly, some gaps are identified for future research.
Endogenous Sox8 is a critical factor for timely remyelination and oligodendroglial cell repletion in the cuprizone model
Authors: Freudenstein David , Lippert Magdalena , Popp Janina Sophie , Aprato Jessica , Wegner Michael , Sock Elisabeth , Haase Stefanie , Linker Ralf A. , Alvarado María Nazareth González 
Published: July 2023

Abstract
Genome-wide association studies identified a single nucleotide polymorphism (SNP) downstream of the transcription factor Sox8, associated with an increased risk of multiple sclerosis (MS). Sox8 is known to influence oligodendrocyte terminal differentiation and is involved in myelin maintenance by mature oligodendrocytes. The possible link of a Sox8 related SNP and MS risk, along with the role of Sox8 in oligodendrocyte physiology prompted us to investigate its relevance during de- and remyelination using the cuprizone model. Sox8−/− mice and wildtype littermates received a cuprizone diet for 5 weeks (wk). Sox8−/− mice showed reduced motor performance and weight compared to wildtype controls. Brains were histologically analysed at the maximum of demyelination (wk 5) and on two time points during remyelination (wk 5.5 and wk 6) for oligodendroglial, astroglial, microglial and myelin markers. We identified reduced proliferation of oligodendrocyte precursor cells at wk 5 as well as reduced numbers of mature oligodendrocytes in Sox8−/− mice at wk 6. Moreover, analysis of myelin markers revealed a delay in remyelination in the Sox8−/− group, demonstrating the potential importance of Sox8 in remyelination processes. Our findings present, for the first time, compelling evidence of a significant role of Sox8 in the context of a disease model.
Does lower extremity alignment during normal stance predict lower limb kinematics and kinetics during drop landings?
Authors: Sayers Mark G.L. , Collings Tyler J. , Mellifont Daniel B. , Stuelcken Max C. , Buhmann Robert L. 
Published: July 2023

Abstract
Background
Static lower extremity alignment (LEA) during normal stance has been used clinically as a tool to determine the presence of known anterior cruciate ligament (ACL) risk factors during dynamic tasks. Previous work investigating the relationship between static LEA during normal stance and risk factors for ACL injury is limited by the use of imprecise methods or focuses on knee valgus only and no other potentially important variables. The aim of this investigation was to determine the relationships between static LEA and the corresponding LEA during drop landings.
Methods
Forty-one female athletes were recruited for the study (age: 19.8 ± 2.5 years, height: 1.73 ± 0.06 m, mass: 64.03 ± 6.66 kg). Lower limb kinematic data were collected using a 10 camera infrared motion capture system (500 Hz) with retro-reflective markers placed over key anatomical landmarks. This system was linked to two force platforms (1000 Hz) with subsequent three-dimensional kinematic and kinetic data developed using standard software (Visual3D). Following an appropriate warm-up, data collection involved participants standing with their arms partially abducted to record static LEA. This was following by a series of drop landings from a 0.4 m box onto the force platforms. Maximum LEA data during drop landings were then compared with static LEA.
Results
Analyses showed that in comparison to static stance, during landings the anterior tilt of the pelvis decreased while hip abduction and knee internal rotation increased. At best, static LEA variables were moderately correlated (r = -0.51 to 0.58) with peak values measured during drop landings. Additionally, regression analysis did not yield any significant predictions of any key peak hip or knee variables measured during drop landing (p = 0.15 to 0.89).
Conclusion
When combined, the poor relationships between kinematics during static LEA and LEA during drop landings observed calls into question the practice of using static measures to predict LEA during even simple landing tasks. These findings suggest static assessments of LEA may have minimal value as an ACL injury screening tool.
AI vs Humans: The Future of Academic Peer Review in Public Administration
Authors: Salah Mohammed , Abdelfattah Fadi , Alhalbusi Hussam 
Published: July 2023

Abstract
In the ever-evolving landscape of academia, artificial intelligence (AI) presents promising opportunities for enhancing the academic review process. In this study, we evaluated the proficiency of Bard and GPT-4, two of the most advanced AI models, in conducting academic reviews. Bard and GPT-4 were compared to human reviewers, highlighting their capabilities and potential areas for improvement. Through a mixed-methods approach of quantitative scoring and qualitative thematic analysis, we observed a consistent performance of the AI models surpassing human reviewers in comprehensibility, clarity of review, the relevance of feedback, and accuracy of technical assessments. Qualitative analysis revealed nuanced proficiency in evaluating structure, readability, argumentation, narrative coherence, attention to detail, data analysis, and implications assessment. While Bard exhibited exemplary performance in basic comprehension and feedback relevance, GPT-4 stood out in detailed analysis, showcasing impressive attention to minor discrepancies and meticulous scrutiny. The results underscore the potential of AI as an invaluable tool in the academic review process, capable of complementing human reviewers to improve the quality, efficiency, and effectiveness of reviews. However, we also identified areas where human reviewers excel, particularly in understanding complex academic language and intricate logical progressions, offering crucial insights for future AI model training and development.
Medical history of thyroid cancer does not impair prognosis in early breast cancer patients: an analysis study based on SEER database and external cohort
Authors: Li Shuai , Chen Xiaosong , Shen Kunwei 
Published: July 2023

Abstract
Early breast cancer patients who had a medical history of skin or cervix cancers were presently eligible for clinical trials while few data were available regarding thyroid gland cancer. The study estimated the rate of prior thyroid gland cancer and evaluated its impact on survivals among breast cancer patients. Early invasive breast cancer patients from the SEER database (SEER cohort) between 2010 and 2019 and Ruijin Hospital (Ruijin cohort) during 2009 and 2019 were retrospectively analyzed. Ascian or Pacific Island patients in the SEER cohort (SEER API cohort) were analyzed separately. Chi-square test and multivariate logistic regression analysis were performed to describe the clinical features. Kaplan-Meier analysis and Cox proportional hazards model were used to compare the overall survival (OS) and breast cancer specific survival (BCSS). A total of 136,441 patients from the SEER cohort, 17,183 from the SEER API cohort, and 8,079 from the Ruijin cohort were enrolled, of whom 0.68%, 0.81%, and 1.06% had a medical history of thyroid gland cancer, respectively. Patients with prior thyroid gland cancers were significantly older (51-60 years: OR 1.84, 95% CI 1.46-2.30, P < 0.001; 61-70 years: OR 2.00, 95% CI 1.61-2.50, P < 0.001; > 70 years: OR 1.51, 95% CI 1.18-1.92, P = 0.001) and more likely to be API (OR 1.23, 95% CI 1.03-1.48, P = 0.026) versus other races. Multivariate analysis demonstrated that patients with a history of thyroid gland cancer had comparable OS (SEER: HR 0.87, 95% CI 0.68-1.11, P = 0.257; SEER API: HR 0.53, 95% CI 0.22-1.28, P = 0.159; Ruijin: HR 1.07, 95% CI 0.26-4.29, P = 0.811) and BCSS (SEER: HR 0.72, 95% CI 0.49-1.08, P = 0.117; SEER API: HR ∞, 95% CI ∞-∞, P = 0.878; Ruijin: HR 0.70, 95% CI 0.10-4.98, P = 0.750) versus those without primary malignancies in the three cohorts. There were of a sizable of early breast cancer patients with medical history of thyroid gland cancer, which was related with different races. Prior thyroid gland cancer had no adverse impact on clinical outcomes, indicating possible eligible in further clinical trials.
Large-capacity Fragile Watermarking Scheme for Color Images Based on Prime Number Distribution Theory
Authors: Hao Weijie , Xie Ruixia , Du Qiaoqiao , Wang Jiuru , Zhang Wenyin 
Published: July 2023

Abstract
Color image digital watermarking technology is an important security protection technology to realize secret communication and content authentication. To better achieve the purpose of color image copyright protection, this paper proposes three watermark embedding schemes for color images based on the prime number distribution theory, embedding the RGB three channels of the color carrier image into binary watermark images of the same size to realize large-capacity watermark embedding. The scheme uses the Rivest Cipher 4 (RC4) encryption algorithm to securely encrypt the image information. During the watermark embedding process, the appropriate pixel value is selected for pixel replacement according to the division of the prime number set within 0-255. The experimental results show that the PSNR values of the three schemes are all greater than 40dB, and the NC values are all close to 1. Compared with the existing algorithms, the scheme proposed in this paper has a large embedding capacity, which can resist common image processing attacks while ensuring good imperceptibility of the watermark, and has good tamper detection and localization capabilities.
Recombinant production of human antimicrobial peptide LL- 37 and its secondary structure
Authors: Pavelka Antonín , Vacek Lukáš , Norek Adam , Kobzová Šárka , Janda Lubomír 
Published: July 2023

Abstract
Antimicrobial peptides, including the human cathelicidin LL-37, offer a possible solution to the global problem of bacterial resistance to antibiotics. LL-37 peptide has potent antimicrobial effects against current multidrug-resistant bacterial strains. The peptide itself is also characterized by a very diverse range of immunomodulatory effects. The aim of this study was to produce antimicrobially active peptide LL-37 in E. coli in high yields using an own expression system pUbEx100 with the fusion protein ubiquitin. The results showed that the peptide GLL-37 could be produced in high amounts, but this peptide did not have antimicrobial activity compared to synthetically produced LL-37. The synthetic peptide LL-37 (sLL-37) alone showed potent activity against multidrug-resistant strains Acinetobacter baumannii and Pseudomonas aeruginosa. CD spectroscopy results showed that the produced peptide GLL-37 is in α-helix form in contrast to the sLL-37 (random-coil form). The recombinant peptide GLL-37 can not bind to the membrane in the α-helix form, it would have to be in the form of a random-coil. This study confirms by CD spectroscopy the previously observed mechanism of access of LL-37 peptide to the bacterial membrane obtained by NMR.
ATF3-induced activation of the NF-κB pathway results in acquired PARP inhibitor resistance in pancreatic adenocarcinoma
Authors: Liu Yang , Cao Yizhi , Liu Pengyi , Zhai Shuyu , Liu Yihao , Tang Xiaomei , Lin Jiayu , Shi Minmin , Qi Debin , Deng Xiaxing , Zhu Youwei , Wang Weishen , Shen Baiyong 
Published: July 2023

Abstract
Purpose
Olaparib, an inhibitor of poly-(adenosine diphosphate-ribose) polymerase (PARP), has been shown to have anticancer benefits in patients with pancreatic cancer who have a germline mutation in BRCA1/2. However, resistance acquired on long-term exposure to olaparib significantly impedes clinical efficacy.
Methods
In this study, the chromatin accessibility and differentially expressed transcripts of parental and olaparib-resistant pancreatic cancer cell lines were assessed using the Assay for Transposase Accessible Chromatin with sequencing (ATAC-seq) and mRNA-seq. Detection of downstream genes regulated by transcription factors using ChIP (Chromatin immunoprecipitation assay).
Results
According to pathway enrichment analysis, differentially expressed genes in olaparib-resistant cells were remarkably enriched in the NF-κB signaling pathway. With ATAC-seq, we identified chromatin regions with higher accessibility in olaparib-resistant cells and predicted a series of important transcription factors. Among them, activating transcription factor 3 (ATF3) was significantly highly expressed. Functional experiments verified that inhibition of ATF3 suppressed the NF-κB pathway significantly and restored olaparib sensitivity in olaparib-resistant cells.
Conclusion
Experiments in vitro and in vivo indicate ATF3 enhances olaparib resistance through the NF-κB signaling pathway, suggesting that ATF3 could be employed as an olaparib sensitivity and prognostic indicator in patients with pancreatic cancer.