bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platform evolution in large inter‐organizational collaborative research programs
Authors: Radaelli Giovanni , Spyridonidis Dimitrios , Currie Graeme 
Published: July 2023

AbstractWe examine the role of platform sponsors and program managers in evolving a platform to stimulate inter‐organizational collaboration in large research programs. Through a 5‐year longitudinal case study, we analyzed a large inter‐organizational collaborative research program in England, underpinned by the CLAHRC platform, sponsored by the NIHR. The research program attracted clinical academics in universities and clinical practitioners in a range of healthcare providers to collaborate in an ensemble of projects to drive evidence‐based care for patients with long‐term health conditions. Program managers struggled to facilitate collaboration through the platform, despite a highly decentralized governance approach. Our study identifies three mechanisms through which the platform sponsor and program managers revised the platform's governance strategies to enhance collaboration: (i) they instituted “interruptive events,” which routinely stopped projects, and analyzed if and why organizations struggle to collaborate; (ii) they expanded, rather than restricted, access rules for collaboration through “platform renting”; (iii) they re‐distributed, rather than re‐centralized, governance, to reduce unnecessary interdependences across collaborators attracted by the platform.
Application of small angle X‐ray scattering in exploring the effect of edible oils with different unsaturation FAs on bioaccessibility of stigmasterol oleate
Authors: Wang Ying , Wang Tao , Wang Zhangtie , Guo Yiwen , Liu Ruijie , Chang Ming 
Published: July 2023

AbstractBACKGROUNDPhytosterol can improve its lipid solubility, lipophilic/hydrophilic balance and bioaccessibility by esterification with fatty acids, which increases its practical application range in the food industry. In the present study, small angle X‐ray scattering combined with the pH‐stat in vitro digestion model was applied to continuously monitor the molecular structure evolution of mixed micelles during digestion and investigate the effect of three edible oils (olive oil with 72.41 ± 0.57% oleic, sunflower seed oil with 63.45 ± 0.78% linoleic, refined linseed oil with 51.74 ± 0.34% linolenic) on bioaccessibility of stigmasterol oleate in vitro.RESULTSThe release degree and rate of fatty acids in the three edible oil systems (kOO+ST‐OA = 0.0501, kSO+ST−OA = 0.0357, kLO+ST‐OA = 0.0323) was compared. The three different edible oils had similar impact on the formation of dietary mixed micelles during the simulatedin vitro digestion of stigmasterol oleate, although there were significant differences in molecular morphology and composition of mixed micelles. The results showed that the vesicles formed by linoleic oil (SO system) or linolenic oil (LO system) were easy to dissociate. The largest average number and diameter of vesicles (5.55 × 1016 cm−3 and 2230.75 Å), the most stable vesicle structure and the fastest fatty acid release rate were observed in the OO system.CONCLUSIONCompared to linoleic (SO system) or linolenic (LO system), the oleic (OO system) could facilitate the transformation of micelles to vesicles and maintain the stability of its membrane, significantly promotin the dissolution of stigmasterol and improving bioaccessibility. © 2023 Society of Chemical Industry.
Iodine biofortification of Swiss chard (Beta vulgaris ssp. vulgaris var. cicla) and its wild ancestor sea beet (Beta vulgaris ssp. maritima) grown hydroponically as baby leaves: effects on leaf production and quality
Authors: Puccinelli Martina , Rosellini Irene , Malorgio Fernando , Pardossi Alberto , Pezzarossa Beatrice 
Published: July 2023

AbstractBACKGROUNDAbout 35–45% of the global population is affected by iodine deficiency. Iodine intake can be increased through the consumption of biofortified vegetables. Given the increasing interest in wild edible species of new leafy vegetables due to their high nutritional content, this study aimed to evaluate the suitability of Swiss chard (Beta vulgaris ssp. vulgaris var. cicla) and its wild ancestor sea beet (Beta vulgaris ssp. maritima) to be fortified with iodine. Plants were cultivated hydroponically in a nutrient solution enriched with four different concentrations of iodine (0, 0.5, 1.0, and 1.5 mg L−1), and the production and quality of baby leaves were determined.RESULTSSea beet accumulated more iodine than Swiss chard. In both subspecies, increasing the iodine concentration in the nutrient solution improved leaf quality as a result of greater antioxidant capacity – the ferric reducing ability of plasma (FRAP) index increased by 17% and 28%, at 0.5 and 1.5 mg L−1 iodine, respectively – the content of flavonoids (+31 and + 26%, at 1 and 1.5 mg L−1 of iodine, respectively), and the lower content of nitrate (−38% at 1.5 mg L−1 of iodine) and oxalate (−36% at 0.5 mg L−1 of iodine). In sea beet, however, iodine levels in the nutrient solution higher than 0.5 mg L−1 reduced crop yield significantly.CONCLUSIONSBoth subspecies were found to be suitable for producing iodine‐enriched baby leaves. The optimal iodine levels in the nutrient solution were 1.0 in Swiss chard and 0.5 mg L−1 in sea beet, as crop yield was not affected at these concentrations and leaves contained enough iodine to satisfy an adequate daily intake with a serving of 100 g. © 2023 Society of Chemical Industry.
Mie Scattering for Photonic Devices
Authors: Dorodnyy Alexander , Smajic Jasmin , Leuthold Juerg 
Published: July 2023

AbstractMie scattering is increasingly exploited to manipulate electromagnetic fields to achieve strong resonant enhancement, to obtain perfect absorption of radiation, and to generate polarization or wavelength selectivity and/or sensitivity. In fact, a multitude of photonic applications are arising that benefit from Mie scattering and have already led to the formation of novel image and hologram schemes or to the design of efficient and compact photodetectors and light sources. Here, the Mie scattering theory for spherical scatterers is reviewed, the basics of the field‐decomposition onto the Mie modes are shown, and dielectric and metallic particles are compared. Recent applications for light spectrum control, detection, non‐linear effects enhancement, and emission are reviewed. How a periodic arrangement of Mie‐scatterers can be utilized to create a strong (in the order of 10 to 100) absorption enhancement in otherwise weakly absorbing layers is also demonstrated. The enhancement dependence on the diameter‐to‐wavelength ratio of the scatterer is analyzed, and how the influence of different Mie‐modes can be distinguished in the periodic array by looking at the field components normal to the scatterer surface is discussed.
Structural characterisation of iron sulfide tribofilms formed on carbon and stainless steels
Authors: Miyajima Makoto , Yonemura Mitsuharu , Kitamura Kazuyuki , Matsumoto Keishi , Yagi Kazuyuki 
Published: July 2023

AbstractThis study investigated tribofilm layers formed under boundary lubrication using a polysulfide additive on S45C and SUS304 steel surfaces. In the tribotests, the friction coefficient of the SUS304 disc fluctuated and increased more gradually in comparison to that of the S45C disc. The tribofilm on the S45C disc comprised the outermost and inner layers of FeS2 (pyrite) and FeS (troilite), respectively. Notably, all the tribofilm layers on the SUS304 disc surface contained pyrite. The tribofilm on the SUS304 disc was weakly crystalline in the outermost layer and thinner than that on the S45C disc. The poor formation of the tribofilm on the SUS304 disc was potentially caused by the unstable friction coefficient and scuffing.
Electrospun Polymeric Fibers Decorated with Silk Microcapsules via Encapsulation and Surface Immobilization for Drug Delivery
Authors: Yang Lingbing , Zhang Yilin , Xiao Zeyun , Zhang Wenbo , Li Linhao , Fan Yubo 
Published: July 2023

AbstractHollow polymer microcapsules as drug carriers have the advantages of drug protection, storage, and controlled release. Microcapsules combined with tissue engineering scaffolds such as electrospun microfibers can enhance long‐term local drug retention. However, the combination methods of microcapsules and fibers still need to be further explored. Here, different technical approaches to functionalize electrospun polycaprolactone (PCL) microfibers with silk fibroin (SF) microcapsules through encapsulation and surface immobilization are developed, including direct blending and emulsion electrospinning for encapsulation, as well as covalent and cleavable disulfide‐linkage for surface immobilization. The results of “blending” approach show that silk microcapsules with different sizes could be uniformly encapsulated inside electrospun fibers without aggregation. To further reduce the use of organic solvents, the microcapsules in the aqueous phase can be uniformly distributed in the PCL organic phase and successfully electrospun into fibers using surfactant span‐80. For surface immobilization, silk microcapsules are efficiently covalent binding to the surface of electrospun PCL fibers via click chemistry and exhibited noncytotoxic. Based on this method, with the incorporation of a disulfide bond, the linkages between microcapsule and fiber could be cleaved under reducing conditions. These microcapsule‐electrospun fiber combination methods provide sufficient options for different drug delivery requirements.
Thermally Reversible Cross‐Linking of Recyclable Polyamide Materials Based on Schiff Base and Diels–Alder Reactions
Authors: Wu Wenjin , Yang Han , Liu Jiakang , Luo Yiqian , Mo Guanhuan , Hu Zhigao , Zhang Lidong , Huang Kun 
Published: July 2023

AbstractRecyclability of cross‐link polymer materials is essential to alleviate environmental pollution caused by discarded or damaged polymers. Herein, a facile method for producing recyclable polyamide materials is developed. Linear polymer chains are constructed by Schiff base reaction between glutaraldehyde (GD) and furandiamine (FD). The linear polymer chains are crosslinked by bismaleimide (BM) to give rise to polyamide material, named GF‐BMs. The resulting GF‐BMs polyamide material possesses strong tensile strength (78 MPa) and good solvent resistance from room temperature to 135 °C. Especially, the thermally reversible Diels–Alder covalent bonds and dynamic imine bonds in the polymer network have a synergistic effect on fast‐reprocessing, self‐healing, and recyclability, which provides a new idea for recyclable materials.
The ubiquitin‐specific protease 5 mediated deubiquitination of LSH links metabolic regulation of ferroptosis to hepatocellular carcinoma progression
Authors: Yan Bokang , Guo Jiaxing , Wang Zuli , Ning Jieling , Wang Haiyan , Shu Long , Hu Kuan , Chen Ling , Shi Ying , Zhang Lingqiang , Liu Shuang , Tao Yongguang , Xiao Desheng 
Published: July 2023

AbstractEpigenetic regulators and posttranslational modifications of proteins play important roles in various kinds of cancer cell death, including ferroptosis, a non‐apoptotic form of cell death. However, the interplay of chromatin modifiers and deubiquitinase (DUB) in ferroptosis remains unclear. Here, we found that ubiquitin‐specific protease 5 (USP5) is regarded as a bona fide DUB of lymphoid‐specific helicase (LSH), a DNA methylation repressor, in hepatocellular carcinoma (HCC). Functional studies reveal that USP5 interacts with LSH and stabilizes LSH by a deubiquitylation activity‐dependent process. Furthermore, the USP5‐mediated deubiquitination of LSH facilitates the tumorigenesis of HCC by upregulating solute carrier family 7 member 11 (SLC7A11) to suppress ferroptosis of liver cancer cells. Moreover, the USP5 inhibitor degrasyn inhibits DUB activities of USP5 to LSH to suppress the progression of HCC. Additionally, USP5 and LSH are positively correlated and both are overexpressed and linked to poor prognosis in HCC patients. Together, our findings show that USP5 interacts with LSH directly and enhances LSH protein stability through deubiquitination, which, in turn, promotes the development of HCC by suppressing ferroptosis of liver cancer cells, suggesting that USP5 may be a potential therapeutic target for HCC.
Interaction of Mitochondrial Polygenic Score and Lifestyle Factors in LRRK2 p.Gly2019Ser Parkinsonism
Authors: Lüth Theresa , Gabbert Carolin , Koch Sebastian , König Inke R. , Caliebe Amke , Laabs Björn‐Hergen , Hentati Faycel , Sassi Samia Ben , Amouri Rim , Spielmann Malte , Klein Christine , Grünewald Anne , Farrer Matthew J. , Trinh Joanne 
Published: July 2023

ABSTRACTBackgroundA mitochondrial polygenic score (MGS) is composed of genes related to mitochondrial function and found to be associated with Parkinson's disease (PD) risk.ObjectiveTo investigate the impact of the MGS and lifestyle/environment on age at onset (AAO) in LRRK2 p.Gly2019Ser parkinsonism (LRRK2‐PD) and idiopathic PD (iPD).MethodsWe included N = 486 patients with LRRK2‐PD and N = 9259 with iPD from the Accelerating Medicines Partnership® Parkinson's Disease Knowledge Platform (AMP‐PD), Fox Insight, and a Tunisian Arab‐Berber founder population. Genotyping data were used to perform the MGS analysis. Additionally, lifestyle/environmental data were obtained from the PD Risk Factor Questionnaire (PD‐RFQ). Linear regression models were used to assess the relationship between MGS, lifestyle/environment, and AAO.ResultsOur derived MGS was significantly higher in PD cases compared with controls (P = 1.1 × 10−8). We observed that higher MGS was significantly associated with earlier AAO in LRRK2‐PD (P = 0.047, β = −1.40) and there was the same trend with a smaller effect size in iPD (P = 0.231, β = 0.22). There was a correlation between MGS and AAO in LRRK2‐PD patients of European descent (P = 0.049, r = −0.12) that was visibly less pronounced in Tunisians (P = 0.449, r = −0.05). We found that the MGS interacted with caffeinated soda consumption (P = 0.003, β = −5.65) in LRRK2‐PD and with tobacco use (P = 0.010, β = 1.32) in iPD. Thus, patients with a high MGS had an earlier AAO only if they consumed caffeinated soda or were non‐smokers.ConclusionsThe MGS was more strongly associated with earlier AAO in LRRK2‐PD compared with iPD. Caffeinated soda consumption or tobacco use interacted with MGS to predict AAO. Our study suggests gene–environment interactions as modifiers of AAO in LRRK2‐PD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Observing exocrine pancreas metabolism using a novel pancreas perfusion technique in combination with hyperpolarized [1‐13C]pyruvate
Authors: Rushin Anna , McLeod Marc A. , Ragavan Mukundan , Merritt Matthew E. 
Published: July 2023

AbstractIn a clinical setting, ex vivo perfusions are routinely used to maintain and assess organ viability prior to transplants. Organ perfusions are also a model system to examine metabolic flux while retaining the local physiological structure, with significant success using hyperpolarized (HP) 13C NMR in this context. We use a novel exocrine pancreas perfusion technique via the common bile duct to assess acinar cell metabolism with HP [1‐13C]pyruvate. The exocrine component of the pancreas produces digestive enzymes through the ductal system and is often neglected in research on the pancreas. Real‐time production of [1‐13C]lactate, [1‐13C]alanine, [1‐13C]malate, [4‐13C]malate, [1‐13C]aspartate, and H13CO3− was detected. The appearance of these resonances indicates flux through both pyruvate dehydrogenase and pyruvate carboxylase. We studied excised pancreata from C57BL/6J mice and NOD.Rag1−/−.AI4α/β mice, a commonly used model of Type 1 Diabetes (T1D). Pancreata from the T1D mice displayed increased lactate to alanine ratio without changes in oxygen consumption, signifying increased cytosolic NADH levels. The mass isotopologue analysis of the extracted pancreas tissue using gas chromatography–mass spectrometry revealed confirmatory 13C enrichment in multiple TCA cycle metabolites that are products of pyruvate carboxylation. The methodology presented here has the potential to provide insight into mechanisms underlying several pancreatic diseases, such as diabetes, pancreatitis, and pancreatic cancer.
Vascular differences between IDH‐wildtype glioblastoma and astrocytoma IDH‐mutant grade 4 at imaging and transcriptomic levels
Authors: Álvarez‐Torres María del Mar , López‐Cerdán Adolfo , Andreu Zoraida , de la Iglesia Vayá Maria , Fuster‐Garcia Elies , García‐García Francisco , García‐Gómez Juan M. 
Published: July 2023

AbstractGlobal agreement in central nervous system (CNS) tumor classification is essential for predicting patient prognosis and determining the correct course of treatment, as well as for stratifying patients for clinical trials at international level. The last update by the World Health Organization of CNS tumor classification and grading in 2021 considered, for the first time, IDH‐wildtype glioblastoma and astrocytoma IDH‐mutant grade 4 as different tumors. Mutations in the genes isocitrate dehydrogenase (IDH) 1 and 2 occur early and, importantly, contribute to gliomagenesis. IDH mutation produces a metabolic reprogramming of tumor cells, thus affecting the processes of hypoxia and vascularity, resulting in a clear advantage for those patients who present with IDH‐mutated astrocytomas. Despite the clinical relevance of IDH mutation, current protocols do not include full sequencing for every patient. Alternative biomarkers could be useful and complementary to obtain a more reliable classification. In this sense, magnetic resonance imaging (MRI)‐perfusion biomarkers, such as relative cerebral blood volume and flow, could be useful from the moment of presurgery, without incurring additional financial costs or requiring extra effort. The main purpose of this work is to analyze the vascular and hemodynamic differences between IDH‐wildtype glioblastoma and IDH‐mutant astrocytoma. To achieve this, we evaluate and validate the association between dynamic susceptibility contrast‐MRI perfusion biomarkers and IDH mutation status. In addition, to gain a deeper understanding of the vascular differences in astrocytomas depending on the IDH mutation, we analyze the transcriptomic bases of the vascular differences.
An iterative multi‐fidelity approach for model order reduction of multidimensional input parametric PDE systems
Authors: Chetry Manisha , Borzacchiello Domenico , Lestandi Lucas , Da Silva Luisa Rocha 
Published: July 2023

AbstractWe propose a parametric sampling strategy for reduction of large scale PDE systems with multidimensional input parametric spaces by leveraging models of different fidelity. The design of this methodology allows a user to adaptively sample points ad hoc from a discrete training set with no prior requirement of error estimators. It is achieved by exploiting low‐fidelity models throughout the parametric space to sample points using an efficient sampling strategy, and at the sampled parametric points, high‐fidelity models are evaluated to recover the reduced basis functions. The low‐fidelity models are then adapted with the reduced order models built by projection onto the subspace spanned by the recovered basis functions. The process continues until the low‐fidelity model can represent the high‐fidelity model adequately for all the parameters in the parametric space. Since the proposed methodology leverages the use of low‐fidelity models to assimilate the solution database, it significantly reduces the computational cost in the offline stage. The highlight of this article is to present the construction of the initial low‐fidelity model, and a sampling strategy based on the discrete empirical interpolation method. We test this approach on a 2D steady‐state heat conduction problem for two different input parameters and make a qualitative comparison with the classical greedy reduced basis method and with random selection of points. Further, we test the efficacy of the proposed method on a 9‐dimensional parametric non‐coercive elliptic problem and analyze the computational performance based on different tuning of greedy selection of points.
Creating the nursing care map in the evaluation of kidney transplant candidates: A scoping review and narrative synthesis
Authors: Pedreira‐Robles Guillermo , Garcimartín Paloma , Bach‐Pascual Anna , Giró‐Formatger Dolors , Redondo‐Pachón Dolores , Morín‐Fraile Victoria 
Published: July 2023

AbstractAimsTo analyse the aspects involved in the care of individuals assessed as kidney transplant candidates and to identify the role of nurses in providing specialised care for this population.DesignScoping review. The results were summarised using a narrative synthesis technique.Data SourcesA review of the literature published between 2001 and 2021 was conducted between October and November 2021 using PubMed, CINAHL and SciELO.Review MethodsThe research team agreed on a search strategy based on clinical practice guidelines for assessing kidney transplantation candidates. Quantitative, qualitative and mixed methods studies published in peer‐reviewed journals in English, Spanish, French and Portuguese were included.ResultsA total of 377 studies were identified, and 49 articles were included after the inclusion and exclusion criteria were applied. The narrative synthesis was structured into four themes: Physical needs; Psychological and quality of life needs; Education and adherence needs; and Nurses' role.ConclusionNursing assessment of kidney transplantation candidates should encompass physical, psychosocial and adherence aspects. A variety of methodologies and resources are available for this assessment. Nurses contribute to coordinating access to kidney transplantation, aiming to improve adherence to an appropriate lifestyle to prevent patients from being excluded from kidney transplantation or suffering from kidney transplantation–related complications.ImpactBased on our findings, we managed to design a nursing care map for kidney transplantation candidates combining the main elements of nursing care that should be incorporated into this process. Advanced practice nursing professionals play a crucial role in accessing renal transplant care.
Ru(phen)3Cl2‐Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes
Authors: Su Wenhao , Cui Jing , Zeng Runsheng 
Published: July 2023

AbstractA novel Ru(phen)3Cl2‐catalyzed free‐radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8‐aminoquinoline‐derived inert enamides were reacted with the Togni regent to afford a broad range of Cl‐containing trifluoromethyl derivatives in good yields. The reaction proceeded at 90 °C and experimental result shows that the chlorine source of the products originated from LiCl.