bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural disconnection relates to functional changes after temporal lobe epilepsy surgery
Authors: Sainburg Lucas E , Janson Andrew P , Johnson Graham W , Jiang Jasmine W , Rogers Baxter P , Chang Catie , Englot Dario J , Morgan Victoria L 
Published: April 2023

Abstract
Epilepsy surgery consists of surgical resection of the epileptic focus and is recommended for patients with drug-resistant focal epilepsy. However, focal brain lesions can lead to effects in distant brain regions. Similarly, the focal resection in temporal lobe epilepsy surgery has been shown to lead to functional changes distant from the resection. Here we hypothesize that there are changes in brain function caused by temporal lobe epilepsy surgery in regions distant from the resection that are due to their structural disconnection from the resected epileptic focus. Therefore, the goal of this study was to localize changes in brain function caused by temporal lobe epilepsy surgery and relate them to the disconnection from the resected epileptic focus. This study takes advantage of the unique opportunity that epilepsy surgery provides to investigate the effects of focal disconnections on brain function in humans, which has implications in epilepsy and broader neuroscience.
Changes in brain function from pre- to post-epilepsy surgery were quantified in a group of temporal lobe epilepsy patients (n = 36) using a measure of resting state functional MRI activity fluctuations. We identified regions with significant functional MRI changes that had high structural connectivity to the resected region in healthy controls (n = 96) and patients based on diffusion MRI. The structural disconnection from the resected epileptic focus was then estimated using presurgical diffusion MRI and related to the functional MRI changes from pre- to post-surgery in these regions.
Functional MRI activity fluctuations increased from pre- to post-surgery in temporal lobe epilepsy in the two regions most highly structurally connected to the resected epileptic focus in healthy controls and patients—the thalamus and the fusiform gyrus ipsilateral to the side of surgery (PFWE &lt; 0.05). Broader surgeries led to larger functional MRI changes in the thalamus than more selective surgeries (P &lt; 0.05), but no other clinical variables were related to functional MRI changes in either the thalamus or fusiform. The magnitude of the functional MRI changes in both the thalamus and fusiform increased with a higher estimated structural disconnection from the resected epileptic focus when controlling for the type of surgery (P &lt; 0.05). These results suggest that the structural disconnection from the resected epileptic focus may contribute to the functional changes seen after epilepsy surgery. Broadly, this study provides a novel link between focal disconnections in the structural brain network and downstream effects on function in distant brain regions.
The Brief Human Immunodeficiency Virus (HIV) Index: A Rapid 3-Item Scale to Measure Engagement in HIV Care
Authors: Sauceda John A , Lisha Nadra E , Ludwig-Barron Natasha , Salazar Jorge , Dilworth Samantha E , Johnson Mallory O , Christopoulos Katerina A , Koester Kimberly A , Moore Richard D , Mayer Kenneth H , Fredericksen Rob J , Mugavero Michael J , Neilands Torsten B 
Published: April 2023

Abstract
We created a brief version of The Index, a validated patient-reported measure that has potential to quickly identify patients at risk for poor retention. We analyzed Index scores from 2406 patients from 2016 to 2017 in a national cohort of patients in human immunodeficiency virus (HIV) care. Index scores predicted poor retention 12 months after administered.
Rare exacerbation of myocardial bridge after septal myocardial ablation in hypertrophic obstructive cardiomyopathy: a case report
Authors: Wu Zhenguo , Li Hongxuan , Zhang Qing , Yang Jianmin 
Published: April 2023

Abstract

Background
Percutaneous transluminal septal myocardial ablation (PTSMA) is an effective means for symptomatic patients with hypertrophic cardiomyopathy (HCM). We present a rare case in which myocardial bridge (MB) was exacerbated in a patient with HCM treated with PTSMA.

Case summary
Here, we present a case of HCM with palpitations and exertional dyspnoea for 2 years. There was no obvious epicardial coronary artery compression before PTSMA. Typical angina occurred 2 months after PTSMA. Coronary angiography showed no obvious stenosis of the coronary arteries, but an exacerbated MB in the middle part of the left anterior descending artery.

Discussion
This patient with HCM presented with typical angina, which might be caused by the rare exacerbation of the MB after PTSMA. Thus, patients with MB should carefully choose PTSMA. Future research is needed for HCM patients complicated with MB treated with PTSMA.
Lipoprotein(a) concentrations in acute myocardial infarction patients are not indicative of levels at six month follow-up
Authors: Ziogos Efthymios , Vavuranakis Michael A , Harb Tarek , Foran Palmer L , Blaha Michael J , Jones Steven R , Lai Shenghan , Gerstenblith Gary , Leucker Thorsten M 
Published: April 2023

Abstract

Aims
Lipoprotein(a) [Lp(a)] levels are generally constant throughout an individual’s lifetime, and current guidelines recommend that a single measurement is sufficient to assess the risk of coronary artery disease (CAD). However, it is unclear whether a single measurement of Lp(a) in individuals with acute myocardial infarction (MI) is indicative of the Lp(a) level six months following the event.

Methods and results
Lp(a) levels were obtained from individuals with non–ST-elevation myocardial infarction (NSTEMI) or ST-elevation myocardial infarction (STEMI) (n = 99) within 24 h of hospital admission and after six months, who were enrolled in two randomized trials of evolocumab and placebo, and in individuals with NSTEMI or STEMI (n = 9) who enrolled in a small observation arm of the two protocols and did not receive study drug, but whose levels were obtained at the same time points. Median Lp(a) levels increased from 53.5 nmol/L (19, 165) during hospital admission to 58.0 nmol/L (14.8, 176.8) six months after the acute infarction (P = 0.02). Subgroup analysis demonstrated no difference in the baseline, six-month, or change between the baseline and six-month Lp(a) values between the STEMI and NSTEMI groups and between the group which received evolocumab and the group that did not.

Conclusion
This study demonstrated that Lp(a) levels in individuals with acute MI are significantly higher six months after the initial event. Therefore, a single measurement of Lp(a) in the peri-infarction setting is not sufficient to predict the Lp(a)-associated CAD risk in the post-infarction period.

Registration
Evolocumab in Acute Coronary Syndrome Trial [EVACS I] NCT03515304, Evolocumab in Patients with Acute Myocardial Infarction [EVACS II], NCT04082442
Breast cancer cell-derived exosome-delivered microRNA-155 targets UBQLN1 in adipocytes and facilitates cancer cachexia-related fat loss
Authors: Sun S , Wang Z , Yao F , Sun K , Li Z , Sun S , Li C 
Published: April 2023

Abstract
Cachexia occurrence and development are associated with loss of white adipose tissues, which may be involved with cancer-derived exosomes. This study attempted to characterize the functional mechanisms of breast cancer (BC) cell-derived exosome-loaded microRNA (miR)-155 in cancer cachexia-related fat loss. Exosomes were incubated with preadipocytes and cellular lipid droplet accumulation was observed using Oil Red O staining. Western blotting evaluated the cellular levels of lipogenesis marker peroxisome proliferator activated receptor gamma (PPARγ) and adiponectin, C1Q and collagen domain containing (AdipoQ). Differentiated adipocytes were incubated with exosomes, and phosphate hormone sensitive lipase (P-HSL), adipose triglyceride lipase (ATGL) and glycerol were detected in adipocytes, in addition to uncoupling protein 1 (UCP1) and leptin levels. A mouse model of cancer cachexia was established where cancer exosomes were injected intravenously. The changes in body weight and tumor-free body weights were recorded and serum glycerol levels and lipid accumulation in adipose tissues were determined. Also, the relationship between miR-155 and UBQLN1 was predicted and verified. BC exosome treatment reduced PPARγ and AdipoQ protein levels, promoted the levels of P-HSL and ATGL proteins, facilitated glycerol release, increased UCP1 expression and lowered leptin expression in adipocytes. Exosomal miR-155 inhibited lipogenesis in preadipocytes and boosted the browning of white adipose tissues. miR-155 downregulation alleviated cancer exosome-induced browning of white adipose tissues and fat loss. Mechanistically, miR-155 targeted UBQLN1, and UBQLN1 upregulation reversed the impacts of cancer exosomes. miR-155 loaded by BC cell-derived exosomes significantly affects white adipose browning and inhibition of cancer-derived exosomes.
The influence of early-life animal exposure on the risk of childhood atopic dermatitis, asthma and allergic rhinoconjunctivitis: findings from the Danish National Birth Cohort
Authors: Pinot De Moira Angela , Pearce Neil , Pedersen Marie , Nybo Andersen Anne-Marie 
Published: April 2023

Abstract

Background
Early-life animal exposure has been associated with both protective and harmful effects on asthma and allergic disease. We aimed to explore factors that may modify associations of early-life animal exposure with asthma and allergic disease, so as to better understand these differences in findings.

Methods
We used data from ≤84 478 children from the Danish National Birth Cohort recruited during pregnancy between 1996 and 2002, and linked registry data up to the child’s 13th birthday. Adjusted Cox models were used to examine associations of early-life cat, dog, rabbit, rodent, bird and livestock exposure with atopic dermatitis, asthma and allergic rhinoconjunctivitis overall, and by source of exposure (domestic or occupation), parental history of asthma or allergy, maternal education level and timing of exposure.

Results
Overall, associations between animal exposure and the three outcomes of interest were weak. However, dog exposure was associated with marginally lower risk of atopic dermatitis and asthma [adjusted hazard ratio (aHR) = 0.81, 95% CI: 0.70–0.94 and 0.88, 95% CI: 0.82–0.94, respectively], whereas prenatal domestic bird exposure was associated with slightly increased risk of asthma (aHR = 1.18, 95% CI: 1.05–1.32). Source of exposure, parental history of asthma or allergy and timing of exposure modified associations. Early-life animal exposure did not appear to increase the risk of allergic rhinoconjunctivitis (aHR range = 0.88, 95% CI: 0.81–0.95 to 1.00, 95% CI: 0.91–1.10).

Conclusions
The overall weak associations observed between animal exposure and atopic dermatitis, asthma and allergic rhinoconjunctivitis were modified by type of animal, source of exposure, parental history of asthma or allergy and timing of exposure, suggesting that these factors should be considered when assessing the risks associated with early-life animal exposure.
Antibiotic Prescribing in United States Nursing Homes, 2013–2017
Authors: Riester Melissa R , Deng Yalin , Zullo Andrew R 
Published: April 2023

Abstract
In this national cohort of older adults residing long-term in US nursing homes between 2013 and 2017, we calculated period prevalence estimates for antibiotic prescribing, rates of prescribing, and days of therapy. Among 1 375 062 residents, 66.2% were prescribed at least 1 antibiotic during the nursing home stay. The most prevalent antibiotic classes were fluoroquinolones, sulfonamides and related agents, and first-generation cephalosporins. Levofloxacin, ciprofloxacin, and sulfamethoxazole-trimethoprim were the most prevalent antibiotics. These results can inform antibiotic stewardship interventions to reduce antibiotic overprescribing, improve appropriateness, and reduce related adverse outcomes in nursing homes.
Chaotic gas accretion by black holes embedded in AGN discs as cause of low-spin signatures in gravitational wave events
Authors: Chen Yi-Xian , Lin Douglas N C 
Published: April 2023

ABSTRACTAccretion discs around supermassive black holes not only power active galactic nuclei (AGNs), but also host single and binary embedded stellar-mass black holes (EBHs) that grow rapidly from gas accretion. The merger of these EBHs provides a promising mechanism for the excitation of some gravitational wave events observed by LIGO–Virgo, especially those with source masses considerably larger than isolated stellar-mass black hole binaries. In addition to their mass and mass-ratio distribution, their hitherto enigmatic small spin parameters (χeff) carry important clues and stringent constraints on their formation channels and evolutionary pathways. Here, we show that, between each coalescence, the typical rapid spin of the merged EBHs is suppressed by their subsequent accretion of gas from a turbulent environment, due to its ability to randomize the flow’s spin orientation with respect to that of the EBHs on an eddy-turnover time-scale. This theory provides supporting evidence for the prolificacy of EBH mergers and suggests that their mass growth may be dominated by gas accretion rather than their coalescence in AGN discs.
Known sequence features explain half of all human gene ends
Authors: Shkurin Aleksei , Pour Sara E , Hughes Timothy R 
Published: April 2023

Abstract
Cleavage and polyadenylation (CPA) sites define eukaryotic gene ends. CPA sites are associated with five key sequence recognition elements: the upstream UGUA, the polyadenylation signal (PAS), and U-rich sequences; the CA/UA dinucleotide where cleavage occurs; and GU-rich downstream elements (DSEs). Currently, it is not clear whether these sequences are sufficient to delineate CPA sites. Additionally, numerous other sequences and factors have been described, often in the context of promoting alternative CPA sites and preventing cryptic CPA site usage. Here, we dissect the contributions of individual sequence features to CPA using standard discriminative models. We show that models comprised only of the five primary CPA sequence features give highest probability scores to constitutive CPA sites at the ends of coding genes, relative to the entire pre-mRNA sequence, for 59% of all human genes. U1-hybridizing sequences provide a small boost in performance. The addition of all known RBP RNA binding motifs to the model increases this figure to only 61%, suggesting that additional factors beyond the core CPA machinery have a minimal role in delineating real from cryptic sites. To our knowledge, this high effectiveness of established features to predict human gene ends has not previously been documented.
Ontogenetic social behavior and seasonal abundance of the subtropical krill Nyctiphanes simplex in northwestern Mexican waters
Authors: Mondragón-Neri Gabriel A , Gómez-Gutiérrez Jaime , García-Fernández Franklin , Gendron Diane , Busquets-Vass Geraldine , Robinson Carlos J 
Published: April 2023

Abstract
Nyctiphanes simplex (Euphausiidae) is the key prey for numerous pelagic predators because it is the most abundant of the 12 krill species present in the Gulf of California, forming dense and complex ontogenetic social interactions throughout its life cycle. We describe the diverse social behaviors of N. simplex and estimate its seasonal abundance in the Gulf of California accounting on average 74% of the krill assemblage. N. simplex exhibited complex and dynamic social repertoires of intraspecific behavioral interactions as early as Calyptopis 1 to adult phase, showing all possible ranges of social behavior known for pelagic invertebrates (aggregations, swarms, schools, shoals). We conclude that N. simplex displays different degrees of social behavior that concentrate abundance throughout their life cycle in epibenthic, pelagic and near surface habitats being highly adaptive behavior for feeding and reproduction. However, social interactions also pose a negative effect, facilitating parasite and disease transmission among conspecifics and facilitate predation for diverse visual predators adapted to find and prey on N. simplex aggregations and swarms. We report the most complete integrated evidence of social behavior and dataset of abundance data of any krill species in tropical and subtropical regions that have remained overlooked using traditional zooplankton net sampling methods.
COLD REGULATED GENE 27 and 28 antagonize the transcriptional activity of the RVE8/LNK1/LNK2 circadian complex
Authors: Sorkin Maria L , Tzeng Shin-Cheng , King Stefanie , Romanowski Andrés , Kahle Nikolai , Bindbeutel Rebecca , Hiltbrunner Andreas , Yanovsky Marcelo J , Evans Bradley S , Nusinow Dmitri A 
Published: April 2023

Abstract
Many molecular and physiological processes in plants occur at a specific time of day. These daily rhythms are coordinated in part by the circadian clock, a timekeeper that uses daylength and temperature to maintain rhythms of ∼24 h in various clock-regulated phenotypes. The circadian MYB-like transcription factor REVEILLE 8 (RVE8) interacts with its transcriptional coactivators NIGHT LIGHT-INDUCIBLE AND CLOCK-REGULATED 1 (LNK1) and LNK2 to promote the expression of evening-phased clock genes and cold tolerance factors. While genetic approaches have commonly been used to discover connections within the clock and between clock elements and other pathways, here, we used affinity purification coupled with mass spectrometry (APMS) to identify time-of-day–specific protein interactors of the RVE8-LNK1/LNK2 complex in Arabidopsis (Arabidopsis thaliana). Among the interactors of RVE8/LNK1/LNK2 were COLD-REGULATED GENE 27 (COR27) and COR28, which coprecipitated in an evening-specific manner. In addition to COR27 and COR28, we found an enrichment of temperature-related interactors that led us to establish a previously uncharacterized role for LNK1 and LNK2 in temperature entrainment of the clock. We established that RVE8, LNK1, and either COR27 or COR28 form a tripartite complex in yeast (Saccharomyces cerevisiae) and that the effect of this interaction in planta serves to antagonize transcriptional activation of RVE8 target genes, potentially through mediating RVE8 protein degradation in the evening. Together, these results illustrate how a proteomic approach can be used to identify time-of-day–specific protein interactions. Discovery of the RVE8-LNK-COR protein complex indicates a previously unknown regulatory mechanism for circadian and temperature signaling pathways.
The Economic Geography of Global Warming
Authors: Cruz José-Luis , Rossi-Hansberg Esteban 
Published: April 2023

Abstract
Global warming is a worldwide and protracted phenomenon with heterogeneous local economic effects. We propose a dynamic economic assessment model of the world economy with high spatial resolution to assess its consequences. Our model features several forms of adaptation to local temperature changes, including costly trade and migration, local technological innovations, and local natality rates. We quantify the model at a 1∘×1∘ resolution and estimate damage functions that determine the impact of temperature changes on a region’s fundamental productivity and amenities conditional on local temperatures. Welfare losses from global warming are very heterogeneous across locations, with 20% losses in parts of Africa and Latin America but also gains in some northern latitudes. Overall, spatial inequality increases. Uncertainty about average welfare effects is significant but much smaller for relative losses across space. Migration and innovation are shown to be important adaptation mechanisms. We use the model to study the impact of carbon taxes, abatement technologies, and clean energy subsidies. Carbon taxes delay consumption of fossil fuels and help flatten the temperature curve but are much more effective when an abatement technology is forthcoming.
Validation of the 2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis
Authors: Tomelleri Alessandro , Padoan Roberto , Kavadichanda Chengappa G , Jose Augustine , Singh Kritika , Iorio Luca , Rathore Upendra , Rinaldi Emma , Baldissera Elena , Agarwal Vikas , Dagna Lorenzo , Campochiaro Corrado , Misra Durga Prasanna 
Published: April 2023

Abstract

Objectives
The present study validates the 2022 ACR/European Alliance of Associations for Rheumatology (EULAR) classification criteria for Takayasu’s arteritis (TAK), compared with the 1990 ACR TAK classification criteria.

Methods
The fulfilment of 2022 ACR/EULAR and 1990 ACR TAK criteria from four referral centres was assessed for TAK compared with extracranial giant cell arteritis (EC-GCA) and other controls. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), likelihood ratio of a positive test (LR+) or negative test (LR–), and area under receiver operating characteristics curve (AUC) were calculated.

Results
Among 504 patients with TAK (404 females) and 222 controls (151 females, 144 patients with EC-GCA), the 2022 ACR/EULAR criteria had better sensitivity (95.83% vs 82.94%) and NPV, but poorer specificity (63.51% vs 90.54%), PPV, LR+, LR– and AUC at the pre-determined cut-offs than the 1990 ACR criteria. The 2022 ACR/EULAR criteria had greater specificity (76.06% vs 57.62%) and AUC (0.845 vs 0.771), with similar sensitivity (93% vs 96.53%) in males as in females. The 2022 ACR/EULAR criteria performed similarly with only EC-GCA as controls (sensitivity 95.83%, specificity 60.42%, AUC 0.781). Sensitivity remained similar, whereas specificity was higher for 40–60 years vs &lt;40 years. Cut-offs of ≥6 (sensitivity 91.87%, specificity 82.88%) and ≥7 (sensitivity 86.71%, specificity 86.49%), or removing the point for female sex (sensitivity 92.64%, specificity 81.08%) greatly improved the balance between sensitivity and specificity.

Conclusion
The poor specificity of the 2022 ACR/EULAR TAK criteria in real-life settings was improved by increasing the cut-off to 6 or 7, or removing the point for female sex.
Ten-Year Changes in Vision, Refractive Error, and Corneal Thickness After Descemet Stripping Automated Endothelial Keratoplasty for Fuchs Endothelial Corneal Dystrophy
Authors: Patel Sanjay V. , Hodge David O. , Nau Cherie B. 
Published: April 2023

Purpose:
The goal of this study was to determine changes in best-corrected visual acuity (BCVA), refractive error, and central corneal thickness (CCT) during the first decade after Descemet stripping automated endothelial keratoplasty (DSAEK).

Methods:
Outcomes of all consecutive eyes undergoing DSAEK for Fuchs endothelial corneal dystrophy (FECD) were reviewed; eyes with untreatable comorbidities before DSAEK were excluded. DSAEK was performed through a temporal incision and all eyes were pseudophakic postoperatively. Changes in BCVA, manifest spherical equivalent, manifest cylinder (vector analysis), and CCT were assessed by using generalized estimating equation models.

Results:
BCVA improved between 6 months (0.18 ± 0.12 logarithm of the minimum angle of resolution (logMAR); Snellen equivalent, 20/30) and 5 years (0.10 ± 0.10 logMAR; 20/25; n = 74, P < 0.001) and then remained stable at 10 years (0.09 ± 0.10 logMAR, n = 48, P = 0.22). There was a myopic shift of −0.20 ± 0.51 D between 6 months and 5 years (n = 65, P = 0.002) that remained stable at 10 years (−0.09 ± 0.44 D; 20/25; n = 34, P = 0.33). Manifest cylinder drifted with-the-rule between 6 months and 5 years (n = 65, P < 0.001) and between 5 and 10 years (n = 34, P < 0.001). CCT was stable between 6 months (672 ± 57 μm) and 5 years (677 ± 55 μm, n = 67, P = 0.47), but increased at 10 years (702 ± 60 μm, n = 39, P = 0.001).

Conclusions:
Excellent BCVA can be achieved during the first decade after DSAEK for FECD, although improvement seems to plateau after 5 years. Changes in manifest refractive error were not clinically significant. The gradual increase in CCT was consistent with longer-term changes found after other types of keratoplasty.