bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing Evolution and Key Themes in Food Policy: A Latent Dirichlet Allocation (LDA) Approach
Authors: Liu Yang 
Published: January 2025

ABSTRACTThis study explores food safety law research using the Latent Dirichlet Allocation (LDA) model, analyzing 2540 papers from the Web of Science (1996–2024). Nine key themes were identified: Public Health and Food Safety, Health Management and Supply Chain, Implementation Strategies and Consumer Rights, Behavior and Policy Regulation, Welfare and Impact Assessment, Purchasing Patterns and Product Performance, Food Industry Regulations and Control Measures, Sectoral Support and Risk Assessment, and Agricultural Systems and Environmental Concerns. The latter theme received the most attention, highlighting a focus on sustainable agriculture and environmental stewardship. The study notes a decline in research on Health Management and Supply Chain and Implementation Strategies and Consumer Rights, possibly due to their maturation or the rising importance of environmental issues. Secondary analysis of Agricultural Systems and Environmental Concerns revealed an interdisciplinary nexus of chemistry, environment, and health. Geographical analysis showed diverse national priorities: Australia and Japan emphasized regulatory and consumer themes, while France and India prioritized agricultural sustainability. High entropy values in China and the U.S. indicated broad research themes, while lower entropy in Azerbaijan and Bulgaria reflected concentrated focus. The findings offer actionable recommendations tailored to stakeholders. Policymakers should prioritize adaptive regulations that address emerging health threats and integrate real‐time data systems. Industry professionals are encouraged to adopt advanced technologies, such as blockchain and AI, to enhance food safety and traceability. Researchers are advised to explore intersections between food safety, public health, and environmental sustainability to inform evidence‐based policy reforms. These steps aim to address global challenges, promote public health, and ensure resilient food systems.
Living in the Zone: Incorporating Richard Rothstein's The Color of Law into the Business Law Curriculum
Authors: Shannon Sean J. 
Published: January 2025

AbstractMaking business law topics relevant to students’ lived experiences can be challenging, but there is one business issue that all students share: the need for housing. One aspect of the present housing crisis is the continuing patterns of residential segregation. To address the legacy costs of past practices of residential segregation, students should understand the underlying role of business law in residential housing and how business law can be used to solve these challenges. To aid business law and real estate instructors wishing to address these issues, this teaching note provides exercises using Richard Rothstein's The Color of Law.
Study of Demographic Characteristics, Management Details and Early Life Outcomes of Indigenous Infants With Chronic Neonatal Lung Disease in North Queensland
Authors: Rogers Matthew , Vangaveti Venkat , Ireland Susan , Puvvadi Ramaa 
Published: January 2025

ABSTRACTObjectiveTo study the demographic characteristics, risk factors, management details and clinical outcomes to 12 months corrected age in indigenous and non‐indigenous infants with chronic neonatal lung disease in North Queensland.DesignRetrospective cohort study of infants with chronic neonatal lung disease admitted to a tertiary neonatal intensive care unit in regional Queensland from January 2015 to December 2019.ResultsThere were 139 infants with chronic neonatal lung disease and 425 controls. The incidence of chronic neonatal lung disease in infants born at < 33 weeks gestational age was 32.6% versus 20.4% in indigenous and non‐indigenous infants, respectively (OR 1.8, p value 0.001). Indigenous infants had significantly lower birth weight (830 g vs. 1000 g, p value 0.039), higher rate of maternal smoking during the pregnancy (57.4% vs. 25%, p value < 0.001), were less likely to be inborn (71.4% vs. 88.2%, p value 0.017) or receive adequate course of antenatal corticosteroids (30.2% vs. 59.2%, p value < 0.001), had increased incidence of grade 2 intraventricular haemorrhage (17.5% vs. 4%, p value 0.01) and were more likely to reside in a very remote locality (17.4% vs. 3.9%, p < 0.001). Identified risk factors for chronic neonatal lung disease included lower birth weight (OR 0.99, p value 0.014), lower birth gestation (OR 1.57, p value 0.003), longer duration of continuous positive airway pressure (OR 1.004, p value < 0.001), longer duration of humidified high‐flow nasal prongs (OR 1.003, p < 0.001), doses of surfactant (OR 1.55, p value 0.038) and receiving post‐natal steroids (OR 19.03, p < 0.001). There were no other significant differences in comorbidities, management, complications, number of hospital admissions or weight to 12‐months corrected age.ConclusionsIndigenous infants had increased antenatal risk factors for chronic neonatal lung disease and account for a disproportionate number of cases, however, their outcomes to 12 months corrected age were similar to non‐indigenous infants.
GATA3‐COMT1‐Melatonin as Upstream Signaling of ABA Participated in Se‐Enhanced Cold Tolerance by Regulate Iron Uptake and Distribution in Cucumis sativus L
Authors: Wen Dan , Yang Ning , Zhang Wenjun , Wang Xiao , Zhang Jibo , Nie Wenjing , Song Hualu , Sun Shasha , Zhang Haijuan , Han Yujuan , Qi Mingfang 
Published: January 2025

ABSTRACTSelenium has the function of bio‐stimulating hormone. However, the underlying physiological and molecular mechanisms of melatonin and abscisic acid as secondary messengers in improving cold tolerance by selenium are limited. This study investigated the effects of selenite on the cold stress of cucumber seedlings. The results showed that the content of endogenesis abscisic acid significantly changed with exogenous application of selenite under cold stress. Interestingly, we found that the content of iron significantly changed in this process. Iron uptake and distribution may be the important reason of selenium alleviates cold injury of cucumber seedlings. Whole genes transcriptome was used for screening key genes on leaf and root of cucumber seedlings. To determine the interrelation between abscisic acid and melatonin in selenite alleviating cold stress, abscisic acid inhibitor fluridone and melatonin synthesis inhibitor p‐chlorophenylalanine were used for in‐depth study. The results indicate that melatonin as upstream signal of ABA involved in selenium enhanced cucumber cold tolerance. The results of yeast single hybridization, EMSA, LUC, and overexpression transgenic showed that the transcription factor CsGATA3 regulates the expression of CsCOMT1 in vitro and in vivo and affects melatonin content. This study provides a theoretical basis for cucumber cultivation and breeding.
Relating Photoperiod and Outdoor Temperature With Sleep Architecture in Patients With Neuropsychiatric Sleep Disorders
Authors: Weihrich Katy Sarah , Bes Frederik , de Zeeuw Jan , Haberecht Martin , Kunz Dieter 
Published: January 2025

ABSTRACTWhile artificial light in urban environments was previously thought to override seasonality in humans, recent studies have challenged this assumption. We aimed to explore the relationship between seasonally varying environmental factors and changes in sleep architecture in patients with neuropsychiatric sleep disorders by comparing two consecutive years. In 770 patients, three‐night polysomnography was performed at the Clinic for Sleep & Chronomedicine (St. Hedwig Hospital, Berlin, Germany) in 2018/2019. Sleep times were adjusted to patients' preferred schedules, patients slept in, and were unaware of day‐night indicators. Digital devices and clocks were not allowed. Days were spent outside the lab with work or naps not allowed. After exclusions (mostly due to psychotropic medication), analysis was conducted on the second PSG‐night in 377 patients (49.1 ± 16.8 year; 54% female). Sleep parameters were plotted as 90‐day moving‐averages (MvA) across date‐of‐record. Periodicity and seasonal windows in the MvA were identified by utilizing autocorrelations. Linear mixed‐effect models were applied to seasonal windows. Sleep parameters were correlated with same‐day photoperiod, temperature, and sunshine duration. The MvA of total sleep time (TST) and REM sleep began a 5‐month‐long decline shortly after the last occurrence of freezing 24‐h mean temperatures (correlation of TST between 2018 and 2019 at 2‐month lag: rs361 = 0.87, p < 0.001; maximum peak‐to‐nadir amplitude: ΔTST ~ 62 min, ΔREM ~ 24 min). The MvA nadirs of slow wave sleep (SWS) occurred approximately at the autumnal equinox (correlation between 2018 and 2019: rs361 = 0.83, p < 0.001). Post hoc testing following significant linear mixed‐effect model indicate that TST and REM sleep were longer around November till February than May till August (ΔTST = 36 min; ΔREM = 14 min), while SWS was 23 min longer around February till May than August till November. Proportional seasonal variation of SWS and of REM sleep as percentages of TST differed profoundly (SWS = 31.6%; REM = 8.4%). In patients with neuropsychiatric sleep disorders living in an urban environment, data collected in 2018 show similar patterns and magnitudes in seasonal variation of sleep architecture as the 2019 data. Interestingly, whereas SWS patterns were consistent between years with possible links to photoperiod, annual variations of TST and REM sleep seem to be related to times of outside freezing temperature. For generalization, the data need to be confirmed in a healthy population. No clinical trial was registered.
Privacy‐preserving awareness in sensor deployment for traffic flow surveillance
Authors: Hao Ruru , Liang Shixiao , Zhai Ziyang , Zhou Hang , Wang Xin , Li Xiaopeng , Guan Tianhao 
Published: January 2025

AbstractThe deployment of sensors to monitor traffic flow between origin–destination (OD) pairs, within a specified budget, remains a critical concern for both academic researchers and transportation managers. While these technologies are essential for capturing traffic data, the aspect of privacy has often been overlooked. To bridge this gap, this paper introduced the concept of privacy distance and then proposed an integer programming model to optimize traffic sensor locations by maximizing the coverage of traffic flow while taking into account the punishment brought by the risk of privacy leakage. Furthermore, to address the computational efficiency problem in large‐scale networks, a flow threshold is set to properly remove some OD pairs to balance the model tractability and computational efficiency. Two case studies of different sizes are carried out to discuss the performance. Case 1 validated the effectiveness of the model, while case 2 demonstrated its capability to handle large‐scale problems. The experimental results show that for large‐scale networks, setting a flow threshold can reduce computation time by 96% at the cost of sacrificing 12% of the OD coverage.
Superficial Fungal Infections and Artificial Intelligence: A Review on Current Advances and Opportunities: REVISION
Authors: Hasan Pour Bahareh 
Published: January 2025

ABSTRACTBackgroundSuperficial fungal infections are among the most common infections in world, they mainly affect skin, nails and scalp without further invasion. Superficial fungal diseases are conventionally diagnosed with direct microscopy, fungal culture or histopathology, treated with topical or systemic antifungal agents and prevented in immunocompetent patients by improving personal hygiene. However, conventional diagnostic tests can be time‐consuming, also treatment can be insufficient or ineffective and prevention can prove to be demanding. Artificial Intelligence (AI) refers to a digital system having an intelligence akin to a human being. The concept of AI has existed since 1956, but hasn't been practicalised until recently. AI has revolutionised medical research in the recent years, promising to influence almost all specialties of medicine.ObjectiveAn increasing number of articles have been published about the usage of AI in cutaneous mycoses.MethodsIn this review, the key findings of articles about utilisation of AI in diagnosis, treatment and prevention of superficial fungal infections are summarised. Moreover, the need for more research and development is highlighted.ResultsFifty‐four studies were reviewed. Onychomycosis was the most researched superficial fungal infection. AI can be used diagnosing fungi in macroscopic and microscopic images and classify them to some extent. AI can be a tool and be used as a part of something bigger to diagnose superficial mycoses.ConclusionAI can be used in all three steps of diagnosing, treating and preventing. AI can be a tool complementary to the clinician's skills and laboratory results.
Large Peritoneal Macrophages Play No Role in the Pathogenesis of Postoperative Ileus Induced by Intestinal Manipulation
Authors: Wang Zheng , Modave Elodie , Delfini Marcello , Appeltans Iris , Boeckxstaens Guy , Stakenborg Nathalie 
Published: January 2025

ABSTRACTIntroductionPostoperative ileus (POI) is an iatrogenic disorder marked by temporary impaired gastrointestinal (GI) motility post‐abdominal surgery. Surgical handling of the intestine activates resident macrophages (Mfs), leading to inflammatory cytokine release and leukocyte recruitment into the muscularis, which compromises intestinal contractility. The mechanisms behind this activation are unclear. Recent studies suggest peritoneal Mfs, particularly large peritoneal macrophages (LPMs), might play a role in sterile intestinal inflammation by rapidly recruiting to the serosal layer of the gut and aiding in tissue damage resolution.MethodsTo identify immune cells involved in the early phase of POI, single‐cell RNA sequencing (scRNA‐seq) was conducted. The migration of LPMs post‐surgery was studied using adoptive transfer techniques. LPMs were depleted via intraperitoneal injection of clodronate liposomes. Subsequently, flow cytometry, quantitative PCR (qPCR), and immunofluorescence were performed to assess the impact of LPM depletion and analyze cell populations and inflammatory effects.Results(1) Intestinal manipulation (IM) leads to the accumulation of monocytes, neutrophils, mature Mfs, CD8+ T cells, and LPMs within 2 h post‐surgery. (2) Heparin treatment does not affect gut transit or reduce IL‐6, IL‐1a, and IL‐1b expression in the early phase of POI. (3) Depletion of LPMs via clodronate liposome does not prevent monocyte, neutrophil, and Mfs infiltration in the muscularis externa, nor does it improve gut transit or reduce cytokine expression. (4) LPMs migrate to the serosa after IM but do not enter the muscularis externa.Conclusion and InferencesLPMs adhere to the intestinal serosa following intestinal manipulation but do not migrate into the intestinal muscularis or participate in the inflammatory response and delayed transit. Consequently, LPMs are not involved in the pathogenesis of POI.
Lineage‐specific patterns in the Moraceae family allow identification of convergent P450 enzymes involved in furanocoumarin biosynthesis
Authors: Bouillé Alexandre , Larbat Romain , Kumari Rashmi , Olry Alexandre , Charles Clément , Nelson David R. , Thornton Janet , Villard Cloé , Hehn Alain 
Published: January 2025

Summary
Specialized metabolites are molecules involved in plants' interaction with their environment. Elucidating their biosynthetic pathways is a challenging but rewarding task, leading to societal applications and ecological insights. Furanocoumarins emerged multiple times in Angiosperms, raising the question of how different enzymes evolved into catalyzing identical reactions.
To identify enzymes producing lineage‐specific metabolites, an evolutionary‐based approach was developed and applied to furanocoumarin biosynthesis in Ficus carica (Moraceae). This led to the characterization of CYP71B129–131a, three P450 enzymes whose evolution of the function was investigated using phylogenetics, structural comparisons and site‐directed mutagenesis.
CYP71B129 and CYP71B130,131a were found to hydroxylate umbelliferone (coumarin) and xanthotoxin (furanocoumarin), respectively. Results suggest that CYP71Bs xanthotoxin hydroxylase activity results from duplications and functional divergence of umbelliferone hydroxylase genes. Structural comparisons highlighted an amino acid affecting CYP71Bs substrate specificity, which may play a key role in allowing xanthotoxin hydroxylation in several P450 subfamilies.
CYP71B130‐131a characterization validates the proposed enzyme‐discovery approach, which can be applied to different pathways and help to avoid the classic bottlenecks of specialized metabolism elucidation. The CYP71Bs also exemplify how furanocoumarin‐biosynthetic enzymes can stem from coumarin‐biosynthetic ones and provides insights into the molecular mechanisms underlying the multiple emergences of xanthotoxin hydroxylation in distant P450 subfamilies.
Associations between maternal fish intake and polyunsaturated fatty acid status with childhood asthma in a high fish‐eating population
Authors: Henry Cealan O. , Allsopp Philip J. , Yeates Alison J. , Spence Toni , Conway Marie C. , Mulhern Maria S. , Shroff Emelyn , Shamlaye Conrad F. , Henderson Juliette , van Wijngaarden Edwin , Myers Gary J. , Strain J. J. , McSorley Emeir M. 
Published: January 2025

AbstractBackgroundStudies investigating associations between prenatal polyunsaturated fatty acid status (PUFAs), in particular the anti‐inflammatory n‐3 PUFAs, and the development of childhood asthma have yielded conflicting results.ObjectiveTo determine the associations between maternal fish intake (a rich source of the n‐3 PUFAs), maternal or cord PUFAs with the prevalence of childhood asthma in a high fish‐eating population.MethodsWe examined these associations between fish intake and PUFA concentrations with childhood asthma prevalence in the Seychelles Child Development Study Nutrition Cohort 2, a large observational study in a high fish‐eating population. Maternal fish intake during pregnancy and child's fish intake at 7 years were assessed by questionnaire, with frequency reported as meals/week. Serum concentrations of PUFAs were quantified in maternal blood collected at 28 weeks' gestation (n = 1448) and in cord blood (n = 1088). Asthma in children at 7 years was assessed using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire (n = 1098).ResultsA total of 97 children (10.5%) were reported to have asthma. In regression analysis, the odds of childhood asthma were not associated with maternal fish intake or maternal PUFA status. Cord DHA concentrations were associated with increased asthma prevalence when the highest quartile (≥0.123 mg/mL) was compared with the lowest (<0.061 mg/mL).ConclusionThe results from this current study add to the growing body of evidence that fish consumption during pregnancy is not associated with asthma development in offspring. The associations between cord blood DHA and asthma prevalence are unexpected and warrant further investigation.
Comparative bioactivity analysis of latex and water extract of Euphorbia gaillardotii: chemical profile, antioxidant capacity, effects on water quality, in vitro antimicrobial‐cytotoxic activities, and in silico molecular docking studies
Authors: Husunet Mehmet Tahir , Mese Rumeysa , Yigittekin Esra Sunduz , Ila Hasan Basri 
Published: January 2025

SummaryThe genus Euphorbia, belonging to the family Euphorbiaceae, represents a significant ethnobotanical heritage due to the diverse bioactive properties exhibited. In this study, the phytochemical composition and biological activities of latex and aerial parts of the water extract of Euphorbia gaillardotii were investigated. Phytochemical analyses were performed using gas chromatography‐mass spectrometry and high‐performance liquid chromatography techniques and total antioxidants, phenolics, sugars, organic acids, and aroma components were quantitatively determined. The effects of the test compounds on physicochemical parameters in aqueous media were evaluated by electrical conductivity, dissolved oxygen concentration, and pH measurements. Antimicrobial activity was evaluated on Gram‐positive and Gram‐negative bacteria and yeast strains using the disk diffusion method. The cytotoxic activity on the MCF‐7 human breast cancer cell line was measured spectrophotometrically using the Cell Counting Kit‐8 proliferation/apoptosis detection kit. The results showed that E. gaillardotii latex and aerial parts water extract significantly affected the physicochemical parameters of aqueous media, especially at high concentrations. The test substances displayed antimicrobial activity, with the latex‐impregnated disks demonstrating larger inhibition zones than the aerial parts extract. The results showed that both the latex and extract treatments exhibited concentration‐dependent effects on MCF‐7 cell viability (P < 0.001). Furthermore, in silico docking analyses revealed a robust binding affinity of succinic acid, the most prevalent bioactive compound in the extract, towards the B‐cell lymphoma 2 (Bcl‐2) molecule, with a binding energy of −6.16 kcal/mol. This may be associated with the observed cytotoxicity. These results suggest that E. gaillardotii may be a valuable source for potential pharmacological applications.
Prognostic Value of Combined Detection of MMP‐7 and ALP Levels in Children With Biliary Atresia Post‐Kasai Surgery
Authors: Li Qingzhi , Ye Chaoxiang , Gao Wei 
Published: January 2025

ABSTRACTObjectiveBiliary atresia (BA) remains a prevalent indication for pediatric liver transplantation (LT). We investigated the prognostic value of the serum matrix metalloproteinases 7 (MMP‐7) and alkaline phosphatase (ALP) level combined detection for BA children post‐Kasai surgery.MethodsThis study retrospectively enrolled 85 BA children who underwent Kasai surgery. They were divided into the native liver (NL) and LT groups based on their three‐year postoperative prognosis. Serum MMP‐7 and ALP levels were measured by ELISA. The relationship of intraoperative serum MMP‐7 and ALP levels with preoperative gamma‐glutamyltransferase (GGT), and their impact on the risk of postoperative LT were analyzed by Pearson's correlation coefficient and Kaplan–Meier curves. The independent risk factors (IRFs) for postoperative LT and the predictive value of the serum MMP‐7 and ALP level combined detection for postoperative LT in BA children were analyzed by Cox regression analysis and receiver operating characteristic (ROC) curves. MedCalc software compared the areas under the ROC curves (AUC).ResultsSignificant differences were observed between the two groups in BA classification, postoperative jaundice clearance rate, and cholangitis occurrence. Intraoperative serum MMP‐7 and ALP levels were higher in the LT group and positively correlated with preoperative GGT. High MMP‐7 and ALP levels were IRFs for postoperative LT, while significant jaundice clearance was a protective factor. Combined MMP‐7 and ALP detection (0.926 AUC, 91.30% sensitivity, 87.18% specificity) significantly improved the prediction for LT.ConclusionHigh MMP‐7 and ALP levels are IRFs for post‐Kasai surgery LT in BA children, with their combination providing superior predictive value.