bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impacts of nicotinamide and inositol on the available cells and product performance of industrial baker's yeasts
Authors: Shan Chengpeng , Xia Tianqing , Liu Jiao , Wang Ying , Bai Penggang , Xu Lili , Li Zailu , Zhao Jianzhi , Bao Xiaoming 
Published: July 2023

AbstractA suitable nutrient supply, especially of vitamins, is very significant for the deep display of the inherent genetic properties of microorganisms. Here, using the chemically defined minimal medium (MM) for yeast, nicotinamide and inositol were confirmed to be more beneficial for the performance of two industrial baker's yeasts, a conventional and a high-sugar-tolerant strain. Increasing nicotinamide or inositol to proper levels could enhance the both strains on cell growth and activity and product performance, including trehalose accumulation and leavening performance. The activity of key enzymes (PCK, TPS) and the content of intermediate metabolites (G6P, UDPG) in the trehalose synthesis pathway were promoted by a moderate supply of nicotinamide and inositol. That were also proved that an appropriate amount of niacinamide promoted the transcription of longevity-related genes (PNC1, SIR2), and the proper concentration of inositol altered the phospholipid composition in cells, namely, phosphatidylinositol and phosphatidyl choline. Furthermore, the cell growth and the leavening performance of the both strains were promoted after adjusting inositol to choline to the proper ratio, resulting directly in content changes of phosphatidylinositol and phosphatidyl choline in the cells. While the two strains responded to the different proper ratio of inositol to choline probably due to their specific physiological characteristics. Such beneficial effects of increased nicotinamide levels were confirmed in natural media, molasses and corn starch hydrolyzed sugar media. Meanwhile, such adjustment of inositol to choline ratio could lessen the inhibition of excess inositol on cell growth of the two tested strains in corn starch hydrolyzed sugar media. However, in molasse, such phenomenon was not observed probably since there was higher Ca2+ in it. The results indicated that the effects of nutrient factors, such as vitamins, on cell growth and other properties found out from the simple chemically defined minimal medium were an effective measure to use in improving the recipe of natural media at least for baker's yeast.
Safety, efficacy, and survival of drug-eluting beads-transarterial chemoembolization vs. conventional-transarterial chemoembolization in advanced HCC patients with main portal vein tumor thrombus
Authors: Chen Junwei , Lai Lisha , Zhou Churen , Luo Junyang , Wang Haofan , Li Mingan , Huang Mingsheng 
Published: July 2023

Abstract
Objectives
To compare the efficacy, overall survival (OS) and safety of drug-eluting beads-TACE (DEB-TACE) and C-TACE as initial treatment in advanced hepatocellular carcinoma (HCC) patients with main portal vein tumor thrombus (mPVTT).

Methods
The medical records of consecutive advanced HCC patients with mPVTT who underwent initial DEB-TACE or C-TACE from September 2015 to October 2021 were retrospectively evaluated. Treatment crossover was allowed in this retrospective research. The adverse events, disease control rate (DCR), time to tumor progression (TTP) and OS of patients who underwent DEB-TACE were compared with those of patients who underwent C-TACE.

Results
Eighty-three patients were included: 42 patients in DEB-TACE group and 41 patients in C-TACE group. DEB-TACE could be safely performed in HCC patients with mPVTT, and they gained a better DCR than those submitted to the C-TACE (76.2% vs. 53.7%, P = 0.031), which might have resulted in longer TTP (median TTP: 9.0 months vs. 3.0 months, P < 0.001). Furthermore, DEB-TACE showed significant OS benefits compared with C-TACE (median OS: 12.0 months vs. 5.0 months, P < 0.001). DEB-TACE, absence of arterioportal shunts (APS), leisons with capsular non-infiltration were found to be independent prognostic factors for better OS. Furthermore, subgroup analysis proved that patients with good DCR gained longer OS in DEB-TACE group.

Conclusions
DEB-TACE could be safely performed and improve the DCR of HCC patients with mPVTT, which resulting in longer TTP and OS, compared with C-TACE.
Isolation and identification of antagonistic fungi on coffee leaf rust in the Dieng highlands of Banjarnegara, Indonesia
Authors: Wulansari Nur Kholida , Prihatiningsih Nur , Utami Dewanti Risa , Wiyantono Wiyantono , Riyanto Agus 
Published: July 2023

Abstract
Background
Coffee is an important plantation crop in Indonesia. The coffee cultivation process was disrupted due to the fungus Hemileia vastatrix which causes rust disease. Biological control has the potential to suppress disease development. The diversity of antagonistic fungi such as Trichoderma in nature is very abundant, so it is necessary to explore and find Trichoderma which has the potential as a biological agent in controlling coffee leaf rust. The research aimed to obtain antagonist fungi that have the potential as biological agents in controlling coffee leaf rust naturally in the coffee plant ecosystem.

Result
Morphology of a local antagonist fungus isolate, coded TBK1, was identified as Trichoderma atroviride which had the potential to naturally control coffee leaf rust by H. vastatrix through a mycoparasitic mechanism.

Conclusion
In the Dieng Plateau, Banjarnegara Indonesia, an antagonistic fungus as a biological agent, T. atroviride, was found to control H. vastatrix coffee leaf rust.
Identification of possible SARS-CoV-2 main protease inhibitors: in silico molecular docking and dynamic simulation studies
Authors: Mukherjee Aniruddhya , Pandey Khushhali Menaria , Ojha Krishna Kumar , Sahu Sumanta Kumar 
Published: July 2023

Abstract
Background
COVID-19 was declared a pandemic by the World Health Organisation in 2020 after its outbreak in December 2019 in Wuhan, China. Since researchers have been working to develop specific drugs to cure COVID-19. COVID-19 is caused by the severe acute respiratory cornonavirus2 or popularly known as SARS-CoV2 attacking the ACE2 receptor in the human respiratory system. The main protease translated by the viral genome is a highly conserved protein that plays a crucial role in viral protein replication and transcription. Compounds such as Darunavir and danoprevir have been tested to show potential biological activity against the viral protein, but a high mutation rate defies a permanent solution to this problem.

Results
In this study, virtual screening of natural ligands (around 170,000 molecules) and FDA-approved repurposed drugs retrieved from ZINC Database was carried out against SARS-CoV2 main protease (PDB ID: 7DJR). Molecular coupling was performed for the top three ligands, where ZINC70699832 showed a significantly good binding affinity of − 11.05 kcal/mol. It has shown an interaction affinity for the residues THR-25, PHE-140, LEU-141, ASN-142, GLY-143, SER-144, CYS-145, MET-165, GLU-166, GLN-189 and GLN-192. The molecular dynamic simulation was also performed using GROMACS, for all complexes where the ZINC70699832–7DJR complex showed stability in terms of root mean square deviation.

Conclusion
The study recommends that ZINC70699832 has great potential to serve as a potent inhibitor of the main protease of SARS-CoV2 main protease.
Optimal control of a grid-connected photovoltaic agricultural water pumping system
Authors: Mahinda Mercy W. , Wanjiru Evan M. , Njiri Jackson G. 
Published: July 2023

AbstractOptimization of water pumping systems has been studied using various techniques which include classical, mathematical, and heuristics. Few studies have explored use of optimal controllers in agricultural water pumping applications. Some studies also ignore the interconnection between the water demand and energy used. Introduction of renewable energy sources such as photovoltaic (PV) necessitates different geographical studies as the intensity of the renewable energy varies widely with location. In this paper, an optimal controller for a batteryless grid-connected photovoltaic system to power water supply system for irrigation purposes was developed. The aim was to minimize the operational cost of grid energy by maximizing utilization of photovoltaic power and minimizing the utilization of grid power. A case study was done at a farm in Kajiado (−1.6033257$$^{\circ }$$∘latitude and 36.7863352$$^{\circ }$$∘longitude). The farm photovoltaic, grid power, water pumps (underground and booster pump), and storage tanks were modelled into a binary linear programming optimization problem and solved using intlinprog solver on MATLAB. Energy demand data was collected using a three-phase power logger, while water demand data was collected using onsite water meter and stopwatch timer. Photovoltaic power produced was estimated using Photovoltaic Geographical Information System (PVGIS). Simulation results obtained show that the use of an optimal controller results in reduced cost of energy by 44.4%. Better utilization of renewable photovoltaic energy by 24% was observed, and 3.6% more water was pumped.
Navigation-Assisted Surgery for Locally Advanced Primary and Recurrent Rectal Cancer
Authors: Solbakken Arne M. , Sellevold Simen , Spasojevic Milan , Julsrud Lars , Emblemsvåg Hanne-Line , Reims Henrik M. , Sørensen Olaf , Thorgersen Ebbe B. , Fauske Lena , Ågren Joanna Sara Maria , Brennhovd Bjørn , Ryder Truls , Larsen Stein G. , Flatmark Kjersti 
Published: July 2023

Abstract
Background
In some surgical disciplines, navigation-assisted surgery has become standard of care, but in rectal cancer, indications for navigation and the utility of different technologies remain undetermined.

Methods
The NAVI-LARRC prospective study (NCT 04512937; IDEAL Stage 2a) evaluated feasibility of navigation in patients with locally advanced primary (LARC) and recurrent rectal cancer (LRRC). Included patients had advanced tumours with high risk of incomplete (R1/R2) resection, and navigation was considered likely to improve the probability of complete resection (R0). Tumours were classified according to pelvic compartmental involvement, as suggested by the Royal Marsden group. The BrainlabTM navigation platform was used for preoperative segmentation of tumour and pelvic anatomy, and for intraoperative navigation with optical tracking. R0 resection rates, surgeons’ experiences, and adherence to the preoperative resection plan were assessed.

Results
Seventeen patients with tumours involving the posterior/lateral compartments underwent navigation-assisted procedures. Fifteen patients required abdominosacral resection, and 3 had resection of the sciatic nerve. R0 resection was obtained in 6/8 (75%) LARC and 6/9 (69%) LRRC cases. Preoperative segmentation was time-consuming (median 3.5 h), but intraoperative navigation was accurate. Surgeons reported navigation to be feasible, and adherence to the resection plan was satisfactory.

Conclusions
Navigation-assisted surgery using optical tracking was feasible. The preoperative planning was time-consuming, but intraoperative navigation was accurate and resulted in acceptable R0 resection rates. Selected patients are likely to benefit from navigation-assisted surgery.
Swedish school nurses' experience of identifying students who are exposed to violence – a qualitative study
Authors: Wilhsson Marie , Santo da Silva Erika Hagstrom , Löf Susanna Loander , Larsson Margaretha 
Published: July 2023

Aim: This study aims to describe how school nurses identify students who are being exposed to violence. Design: The study has a qualitative design focusing on illuminating the meanings embodied in lived experiences Method: Fourteen qualitative interviews with school nurses were conducted and a descriptive qualitative meaning analysis was used to cast light on the phenomenon. The COREQ checklist was used to ensure trustworthiness. Results: Four themes were highlighted: opportunity in the health dialogue, necessity to create and prove trustworthiness, cooperation with other professionals, and awareness of factors that could complicate reporting exposure to violence. The study provided new insights such as the school nurse having an important role in the identification of students exposed to violence. It is important that school nurses have an open approach and are systematic in the health dialogue, using questions about violence to create opportunities for students to talk about their living conditions.
Utilidad clínica de los biomarcadores óseos: un desafío a la variabilidad
Authors: Filella Xavier , Guañabens Núria 
Published: July 2023

Resumen
Los biomarcadores óseos son un conjunto de sustancias que son liberadas a la circulación sanguínea durante el proceso de formación y/o resorción ósea y que podemos medir en sangre y orina para obtener información sobre los trastornos metabólicos del hueso. La revisión traza una perspectiva sobre los factores que influyen en la variabilidad de los biomarcadores óseos y describe los aspectos a considerar para reducirla al máximo e interpretar los resultados de manera adecuada. La variabilidad que podemos observar en la concentración de los biomarcadores óseos engloba diversos aspectos que abarcan desde su variabilidad biológica y la variabilidad de los ensayos empleados en su medida hasta la variabilidad derivada de la influencia de numerosos factores, entre los cuales el sexo, la edad, el ejercicio, su ritmo circadiano o la dieta. Todo ello se refleja en la dificultad de establecer valores de referencia precisos. El conocimiento de esta variabilidad es el primer desafío que debe afrontar su empleo en la práctica clínica. Es necesario minimizar la variabilidad de los biomarcadores óseos controlando el máximo de variables que sea posible, así como estandarizando la preparación del paciente antes de la toma de las muestras, así como su obtención y manejo.
Idiosyncratic Shocks, Lumpy Investment and the Monetary Transmission Mechanism
Authors: Reiter Michael , Sveen Tommy , Weinke Lutz 
Published: July 2023

Abstract
Standard (S, s) models of lumpy investment allow us to match many aspects of the micro data, but it is well known that the implied interest rate sensitivity of investment is unrealistically large. In fact, the micro-level lumpiness in investment puts empirical discipline on the modeling of investment decisions, and this makes it hard to explain the monetary policy transmission mechanism.
Is language an issue? Accuracy of the German computerized diagnostic decision support system ISABEL and cross-validation with the English counterpart
Authors: Marcin Thimo , Lüthi Ailin , Graf Ronny R. , Krummrey Gert , Schauber Stefan K. , Breakey Neal , Hautz Wolf E. , Hautz Stefanie C. 
Published: July 2023

Abstract

Objectives
Existing computerized diagnostic decision support tools (CDDS) accurately return possible differential diagnoses (DDx) based on the clinical information provided. The German versions of the CDDS tools for clinicians (Isabel Pro) and patients (Isabel Symptom Checker) from ISABEL Healthcare have not been validated yet.

Methods
We entered clinical features of 50 patient vignettes taken from an emergency medical text book and 50 real cases with a confirmed diagnosis derived from the electronic health record (EHR) of a large academic Swiss emergency room into the German versions of Isabel Pro and Isabel Symptom Checker. We analysed the proportion of DDx lists that included the correct diagnosis.

Results
Isabel Pro and Symptom Checker provided the correct diagnosis in 82 and 71 % of the cases, respectively. Overall, the correct diagnosis was ranked in 71 , 61 and 37 % of the cases within the top 20, 10 and 3 of the provided DDx when using Isabel Pro. In general, accuracy was higher with vignettes than ED cases, i.e. listed the correct diagnosis more often (non-significant) and ranked the diagnosis significantly more often within the top 20, 10 and 3. On average, 38 ± 4.5 DDx were provided by Isabel Pro and Symptom Checker.

Conclusions
The German versions of Isabel achieved a somewhat lower accuracy compared to previous studies of the English version. The accuracy decreases substantially when the position in the suggested DDx list is taken into account. Whether Isabel Pro is accurate enough to improve diagnostic quality in clinical ED routine needs further investigation.
Influence of fractures in tight sandstone oil reservoir on hydrocarbon accumulation: A case study of Yanchang Formation in southeastern Ordos Basin
Authors: Zhang Zaiyu , Liu Weiwei , Wu Xiaodong 
Published: July 2023

Abstract
The southwestern Ordos Basin is located at the junction of several stable plates, where faults and fractures are relatively developed, and the influence of fractures on the distribution of tight oil reservoirs in the Yanchang Formation is not clear. To solve this problem, the characteristics of fracture development of the Yanchang Formation, southwestern Ordos Basin and its control on hydrocarbon accumulation have been systematically studied using the core, thin section, well logging, productivity, fault and sand body distribution data. The results show that vertical and horizontal bedding fractures are much more developed in the Chang 8 Member compared with the Chang 6 and 7 Members. For horizontal bedding fractures, they are mainly developed in fine sandstone, followed by siltstone, while no horizontal bedding fractures are observed in medium sandstone. This is because horizontal bedding fractures are more common in fine-grained sediments. For vertical fractures, they are also mainly developed in fine sandstone. The controlling factors of fractures include lithology, sand body thickness, sedimentary microfacies and fault–fracture coupling relationship. Fractures are well developed in the fine-grained sandstone of the wing parts of the main river channel due to small compacted space. In the area where multiple river channels intersect, the sand is pure and easy to break. Based on the comprehensive study of sedimentation, structure and fracture, the classification criteria of sweet point reservoir of the Yanchang Formation are determined: sedimentary microfacies of the main river channel and its wing, tectonic location within 1.5 km from the main fault, plane arrangement of right-lateral and right-order faults and developed fractures. The sweet point reservoir can be identified effectively using the developed sweet point screening criteria.
Broadband synchronization of ultrafast pulse generation with double-walled carbon nanotubes
Authors: Zheng Jiancheng , Li Diao , Liu Peng , Cui Xiaoqi , Zhang Bin , Geng Wei , Zhang Qiang , Xu Zhenyu , Kauppinen Esko I. , Sun Zhipei 
Published: July 2023

Abstract
Double-walled carbon nanotubes have shown competitive properties in broadband optical pulse generation owning to the intrinsic electronic properties. Synchronization of ultrafast optical pulses in multiple wavelengths is a key technique for numerous applications, such as nonlinear frequency conversion, ultrafast pump-probe, coherent Raman scattering spectroscopy, coherent optical synthesis, etc. In this work, we demonstrate the mode-locking and synchronization of 1.55 µm pulses with 1 µm and 1.9 µm pulses via a single saturable absorber based on double-walled carbon nanotubes. The large optical nonlinearity and broadband optical absorption in the double-walled carbon nanotubes enable independent and synchronized mode-locking in >900 nm bandwidth. In addition, we present a creative concept to realize multi-wavelength synchronization from a single laser system. Our results demonstrate a straightforward and feasible approach towards pulse synchronization over ultra-broad bandwidth with flexible wavelength selection in the near-infrared region.
Dansyl based selective fluorescence sensor for Hg in aqueous environment: an experimental and computational studies
Authors: Qureshi Naseem , Ali Mahar , Shah Shahen , Hussain Manzoor , Hassan Mehdi , Khan Hawas , Ibrahim Sobhy M. , Iqbal Munawar , Nazir Arif , Younas Umer 
Published: July 2023

Abstract
The selective fluorescence sensors are used for the analysis of toxic pollutants in the environment. In this study, phenol dansyl amide (PDA) was prepared as highly stable fluorescence ligand by using nucleophilic substitution reaction. Its interaction with eighteen different cations including Hg2+ and series of anions were investigated by using UV-visible and fluorescent spectrophotometry. However, PDA significantly indicated high sensitivity and selective quenching effect towards mercury ion. Furthermore, Density Functional Theory (DFT) along with the B3LYP method was implemented to explore minimum energy complex and fluorescence mechanism. The computed results revealed that among four possible optimized complexes of PDA and Hg+ ion, the first complex (PDA-Hg2+–I) was observed to be the most stable complex with the estimated energy difference of 8.91 kcal/mol and intermolecular charge transfer mechanism was observed in the same complex by HOMO and LUMO computation.
Prática de profissionais de saúde em aleitamento materno e fatores associados: estudo transversal
Authors: Machado Maria Estela Diniz , Christoffel Marialda Moreira , Velarde Luis Guillermo Coca , Linares Ana Maria , Silveira Ana Luiza Dorneles da , Gomes Ana Letícia Monteiro , Silva Luciana Rodrigues da 
Published: July 2023

Objetivo: analisar a prática dos profissionais de saúde da atenção básica quanto ao aleitamento materno e fatores associados. Método: estudo transversal, analítico, realizado com todos os profissionais de saúde atuantes em aleitamento materno de cinco unidades da atenção básica através de questionário autoaplicável. Para análise da associação de variáveis categóricas com a prática profissional utilizou-se teste Qui-quadrado com nível de significância de 5%. Resultados: participaram 38 profissionais. Houve associação estatística significativa (p=0.04597) entre a variável atualização em aleitamento materno nos últimos cinco anos e prática de implementação em grupos de apoio; o manejo clínico, a orientação quanto aos direitos maternos e o apoio para a resolução de dificuldades na amamentação foram menos informados. Conclusão: a prática dos profissionais de saúde apresentou fragilidades evidenciando a necessidade de valorização do tema por profissionais e gestores através de estratégias que incluam capacitação contínua e monitoramento do aleitamento materno na rede de atenção básica.