bluuebunny/crossref_metadata_2025_split huggingface dataset:
RADIOCARBON DATING OF MANUSCRIPTS KEPT IN THE CENTRAL LIBRARY OF THE UNIVERSITY OF TEHRAN
Authors: Aghaei Ali , Bahrololoumi Faranak , Hajdas Irka , Jafarian Rasul , Kordavani Lili , Marx Michael 
Published: February 2023

ABSTRACTThis article discusses radiocarbon dating results of documents preserved at the Central Library of the University of Tehran (hereafter, CLUT) as part of the project “Irankoran.” The paper adds new evidence to an ongoing campaign of dating Qurʾāns and Oriental manuscripts by the Corpus Coranicum Project. The dated manuscripts include one kūfī fragment of the Qurʾān on parchment (no. 10950) and a selection of Islamic and Persian manuscripts, all from the second millennium: the Arabic dictionary Muǧmal al-Luġah (Meškāt no. 203), the medical encyclopedia Ḏaḫīrah-ye Khwārazmšāhī (no. 5156), the epic Panǧ Ganǧ of Neẓāmī (no. 5179), the book of wisdom Ādāb al-Falāsifah (no. 2165) attributed to Ḥunayn b. Isḥāq (d. 873 CE), and one of the oldest extant manuscripts of the Avesta Wīdēwdād (no. 11263). Although the authenticity of their colophons is disputed, radiocarbon dating supports the dates of the colophons; even in cases where they were suspected of being tampered with, they most likely present the accurate original dates of the corresponding manuscripts. Only in the case of Ādāb al-Falāsifah (no. 2165), radiocarbon dating of the parchment has identified the manuscript as non-authentic. Inconsistent carbon dating results of two samples taken from Ḏaḫīrah-ye Khwārazmšāhī (no. 5156) and Panǧ Ganǧ (no. 5179) provide evidence of later replaced/added leaves.
The Early Political Thought and Publishing Career of V. K. Krishna Menon, 1928–1938
Authors: Bowman Jack 
Published: February 2023

AbstractThis article assesses Indian activist V. K. Krishna Menon's early political thought, formed during his years in Britain prior to Indian independence. It argues that this was more nuanced than has been previously characterized, with a range of influences and foundations. To analyse the formation and evolution of Menon's political thought, it looks at his political actions from this period, which largely fall into three areas; the India League, his engagement with the British Left, and his publishing career. His editorial work is what often tied together these strands of political action and was where his political thought manifested and expressed itself. This article analyses Menon's publishing career from roughly 1928 to 1938, highlighting the engagement of the three strands of his political action, before undertaking a book history of the India League text Condition of India. The article is a continuation of the expansion of book histories of twentieth-century empire, and argues for a reassessment of anti-colonial texts and figures along these lines, whilst also contributing to the growing historiographical trend that seeks to recast modern Indian political thought, as well as the politics of internationalist activists in interwar Britain.
Graph transformation in engineering design: an overview of the last decade
Authors: Voss Christopher , Petzold Frank , Rudolph Stephan 
Published: February 2023

Abstract
In engineering and architecture, different approaches have been developed that share the use of graph transformation to automate design processes or to search for design solutions by means of computational design synthesis. In order to give an overview of these approaches, we provide a review of articles published in the last decade. Forty-eight articles were reviewed to determine similarities and differences of these approaches. Research fields in method development for the representation of design problems and the processing of graph transformations, as well as the application of graph transformations in engineering, architecture, and shape grammars were identified. Different approaches for the documentation of the vocabulary and the rules were examined. Finally, different approaches for rule applications were analyzed. Based on found limitations, future research directions are suggested.
The value /me/ of the sign <MAN> in Achaemenid Elamite
Authors: Fattori Marco 
Published: February 2023

AbstractThe aim of this article is to show that in Achaemenid Elamite the sign <MAN> had a secondary phonetic value /me/. The evidence collected in support of this claim consists mainly in Elamite transcriptions of Iranian words in the Achaemenid Royal Inscriptions and in the Persepolis administrative texts, which are impossible or very difficult to account for only contemplating the usual value /man/.
Psychometric properties of the Turkish version of the Stress Scale for Nurses Providing End-of-Life Care for Children
Authors: Ayran Gülsün , Çevik Özdemir Hamide Nur 
Published: February 2023

AbstractObjectivesThis study was carried out to evaluate the validity and reliability of the Stress Scale for Pediatric Nurses Performing End-of-Life Care for Children in Turkey.MethodsThis was a methodological study conducted with 222 pediatric nurses. Data were collected using the information form for pediatric nurses and the “stress scale for nurses performing end-of-life care for children.” Content and construct validity, item analysis, confirmatory factor analysis and internal consistency were used to evaluate the data. The Global Pharmaceutical Regulatory Affairs Summit checklist was followed in this study.ResultsThe content validity index of the scale was 0.93. Item-total score correlation values ranged from 0.594 to 0.885. The 5-factor structure of the scale was confirmed as a result of confirmatory factor analysis. Factor loads were greater than 0.30, and fit indices were greater than 0.80. The Cronbach’s alpha coefficient of the Turkish version of the scale was 0.97.Significance of resultsThe stress scale for nurses performing end-of-life care for children is a valid and reliable measurement tool for the Turkish sample. This scale facilitates the assessment of the stress levels of pediatric nurses who provide end-of-life care to children. Also, this scale can be used in interventional studies to improve the well-being of pediatric nurses.
Downward Drifting F‐Region Irregularity Observed Above an Eastward Drifting One Before Midnight on 4 March 2014
Authors: Chen Gang , Zhang Min , Yan Chunxiao , Zhang Qiang , Yang Guotao , Li Yaxian , Zhang Shaodong , Gong Wanlin , He Zhiqiu 
Published: February 2023

AbstractOn the night of 4 March 2014, the Hainan COherent Scatter Phased Array Radar (HCOPAR) observed two irregularities appearing simultaneously in the radar scope at different height ranges. The global positioning system total electron content receivers also recorded two groups of plasma bubbles connecting in the observation scope of the HCOPAR. The topside irregularity moved slowly downward with almost no zonal movement, while the bottomside irregularity drifted eastward. There was not much difference among the h’F, hmF, and foF variations recorded by the Hainan Digisonde on that day and the reference days, except for a rapid descent in hmF between 20:45 and 21:15 LT. The downward moving irregularity was also recorded during this period. The prompt penetration electric fields induced by turnings of the interplanetary magnetic field Bz during weak geomagnetic activities are suggested not to influence the whole F‐layer heights at low latitudes but only to change the drift direction of the topside irregularity.
Tracking NO2 Pollution Changes Over Texas: Synthesis of In Situ and Satellite Observations
Authors: Gyawali Madhu S. , Lamsal Lok N. , Sedai Jay R. , Gyawali Bimal , Bhattarai Keshav , Williams Quintaria , Neige Shannon , Sharma Shriram , Aryal Rudra 
Published: February 2023

AbstractNitrogen oxides (NOx) are major air pollutants that play a crucial role in atmospheric chemistry. We compare Ozone Measuring Instrument's (OMI) NO2 records with the in situ surface measurements from the Air Quality System of the US Environmental Protection Agency and the Texas Commission on Environmental Quality network in the state of Texas with the goal of understanding the correspondence of satellite and in situ surface observations and identifying the potential synergies between the two observing systems. Our analysis of over 40 in situ daily surface site observations, mostly from urban areas, and OMI daily observed data suggests a correlation (r) ranging between 0.2 and 0.8. The correlation improves considerably (r > 0.5) for monthly average data. Weekly variation of surface NO2 with a Sunday minimum is well captured by OMI tropospheric NO2 column observations with similar weekend reductions. NO2 trend in Texas during 2005–2019 is characterized by significant reductions of 20%–36% in highly populated cities and urban centers. However, a significant (up to 80%) increase was observed in oil and gas producing regions of the Permian and Eagle Ford Basins over the same period. In March–April of 2020, like the other US and global cities, Texas experienced up to 60% reduction in NO2 levels in major cities due to travel restrictions imposed at local and national levels to contain the spread of COVID‐19. Though such reduction is temporary, these reductions were significantly larger than those achieved in the past 16 years of OMI record suggesting that technological advancement can curtail NOx emissions.
Morphodynamic Characteristics of a Complex Anabranching System in the Qinghai‐Tibet Plateau and the Implications for Anabranching Stability
Authors: Guo Xiwei , Gao Peng , Li Zhiwei 
Published: February 2023

AbstractThe understanding of fluvial processes controlling morphological adjustments and stability of anabranching rivers remains incomplete. Focusing on a complex anabranching system in the Upper Yellow River, this study quantifies the morphological characteristics and lateral dynamics of islands and channels in four reaches over a 56‐km river course from 1986 to 2017. Using five heuristic anabranching structures derived from the studied anabranching system, we estimate sediment transport capacities and assess their implications for the morphodynamics of anabranching rivers. These results show that the system exhibited a highly complex pattern featuring high channel multiplicity and dominance of islands. Over the study periods, the system exhibited an accreting disequilibrium state, which was highlighted by spatiotemporally diverse and dynamic patterns of islands. Morphological changes in islands were dominated by expansion and shrinkage, which caused more areal changes than other modes of change, including coalescence, cleavage, new island formation, and elimination. These processes controlled the creation and elimination of small anabranches, whereas the size and morphology of large channels remained comparatively stable, which maintained the stability of this anabranching pattern. The stability of the anabranching pattern is further supported by estimations of transport capacity in that the main channels transport most sediments and in that excess development of small anabranches promotes sediment deposition within the system. Overall, this study provides new insight into the morphodynamic properties of anabranching rivers, demonstrating that, instead of channel numbers, island dynamics and interactions with channels are controls of the evolutionary processes and stability of anabranching rivers.
Time Domain Reflectometry Waveform Interpretation With Convolutional Neural Networks
Authors: Wang Zhuangji , Hua Shan , Timlin Dennis , Kojima Yuki , Lu Songtao , Sun Wenguang , Fleisher David , Horton Robert , Reddy Vangimalla R. , Tully Katherine 
Published: February 2023

AbstractInterpreting time domain reflectometry (TDR) waveforms obtained in soils with non‐uniform water content is an open question. We design a new TDR waveform interpretation model based on convolutional neural networks (CNNs) that can reveal the spatial variations of soil relative permittivity and water content along a TDR sensor. The proposed model, namely TDR‐CNN, is constructed with three modules. First, the geometrical features of the TDR waveforms are extracted with a simplified version of VGG16 network. Second, the reflection positions in a TDR waveform are traced using a 1D version of the region proposal network. Finally, the soil relative permittivity values are estimated via a CNN regression network. The three modules are developed in Python using Google TensorFlow and Keras API, and then stacked together to formulate the TDR‐CNN architecture. Each module is trained separately, and data transfer among the modules can be facilitated automatically. TDR‐CNN is evaluated using simulated TDR waveforms with varying relative permittivity but under a relatively stable soil electrical conductivity, and the accuracy and stability of the TDR‐CNN are shown. TDR measurements from a water infiltration study provide an application for TDR‐CNN and a comparison between TDR‐CNN and an inverse model. The proposed TDR‐CNN model is simple to implement, and modules in TDR‐CNN can be updated or fine‐tuned individually with new data sets. In conclusion, TDR‐CNN presents a model architecture that can be used to interpret TDR waveforms obtained in soil with a heterogeneous water content distribution.
Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening
Authors: Deng Ling , Yang Li , Zhu Shuhan , Li Man , Wang Yu , Cao Xiaolong , Wang Qiongyao , Guo Linlang 
Published: February 2023

AbstractThere is currently a lack of efficacious treatments for patients with chemo-resistant small-cell lung cancer (SCLC), leading to poor prognoses. We examined a chemo-resistant SCLC cell line using genome-wide CRISPR/Cas9 screening and identified serine/threonine kinase cell division cycle 7 (CDC7) as a potential synergistic target. Silencing CDC7 in chemo-resistant SCLC cells decreased the IC50 and improved the efficacy of chemotherapy. Based on the highest single agent model, the CDC7 inhibitor XL413 had a synergistic effect with both cisplatin and etoposide in chemo-resistant SCLC cells, but had no such effect in chemo-sensitive SCLC cells; the combination of XL413 and chemotherapy significantly inhibited cell growth. Western blot and flow cytometry showed that the combined treatments increased apoptosis, whereas XL413 alone had little effect on apoptosis. An analysis of cell cycle and cyclin protein levels indicated that the combination of XL413 and chemotherapy-induced G1/S phase arrest and DNA damage in chemo-resistant SCLC cells. Xenografted tumor and histoculture drug response assays using patient-derived xenografts showed that XL413 improved the efficacy of chemotherapy in vivo and with SCLC tissues. These results suggest that XL413 exerts a synergistic effect with chemotherapy on chemo-resistant SCLC.
Differential serum microRNAs in premotor LRRK2 G2019S carriers from Parkinson’s disease
Authors: Soto Marta , Fernández Manel , Bravo Paloma , Lahoz Sara , Garrido Alicia , Sánchez-Rodríguez Antonio , Rivera-Sánchez María , Sierra María , Melón Paula , Roig-García Ana , Naito Anna , Casey Bradford , Camps Jordi , Tolosa Eduardo , Martí María-José , Infante Jon , Ezquerra Mario , Fernández-Santiago Rubén 
Published: February 2023

AbstractThe LRRK2 G2019S pathogenic mutation causes LRRK2-associated Parkinson’s disease (L2PD) with incomplete penetrance. LRRK2 non-manifesting carriers (L2NMC) are at PD high risk but predicting pheno-conversion is challenging given the lack of progression biomarkers. To investigate novel biomarkers for PD premotor stages, we performed a longitudinal microRNA (miRNA) assessment of serum samples from G2019S L2NMC followed-up over 8 years. Our cohort consisted of G2019S L2NMC stratified by dopamine transporter single-photon emission computed tomography (DaT-SPECT) into DaT-negative (n = 20) and DaT-positive L2NMC (n = 20), pheno-converted G2019S L2PD patients (n = 20), idiopathic PD (iPD) (n = 19), and controls (n = 40). We also screened a second cohort of L2PD patients (n = 19) and controls (n = 20) (Total n = 158). Compared to healthy controls, we identified eight deregulated miRNAs in DaT-negative L2NMC, six in DaT-positive L2NMC, and one in L2PD. Between groups, the highest miRNA differences, 24 candidate miRNAs, occurred between DaT-positive L2NMC and L2PD. Longitudinally, we found 11 common miRNAs with sustained variation in DaT-negative and DaT-positive L2NMCs compared to their baselines. Our study identifies novel miRNA alterations in premotor stages of PD co-occurring with progressive DaT-SPECT decline before motor manifestation, whose deregulation seems to attenuate after the diagnosis of L2PD. Moreover, we identified four miRNAs with relatively high discriminative ability (AUC = 0.82) between non-pheno-converted DaT-positive G2019S carriers and pheno-converted L2PD patients (miR-4505, miR-8069, miR-6125, and miR-451a), which hold potential as early progression biomarkers for PD.
Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool
Authors: Schaffrath Anja , Schleyken Sophia , Seger Aline , Jergas Hannah , Özdüzenciler Pelin , Pils Marlene , Blömeke Lara , Cousin Anneliese , Willbold Johannes , Bujnicki Tuyen , Bannach Oliver , Fink Gereon R. , Willbold Dieter , Sommerauer Michael , Barbe Michael T. , Tamgüney Gültekin 
Published: February 2023

AbstractMisfolded and aggregated α-synuclein is a neuropathological hallmark of Parkinson’s disease (PD). Thus, α-synuclein aggregates are regarded as a biomarker for the development of diagnostic assays. Quantification of α-synuclein aggregates in body fluids is challenging, and requires highly sensitive and specific assays. Recent studies suggest that α-synuclein aggregates may be shed into stool. We used surface-based fluorescence intensity distribution analysis (sFIDA) to detect and quantify single particles of α-synuclein aggregates in stool of 94 PD patients, 72 isolated rapid eye movement sleep behavior disorder (iRBD) patients, and 51 healthy controls. We measured significantly elevated concentrations of α-synuclein aggregates in stool of iRBD patients versus those of controls (p = 0.024) or PD patients (p < 0.001). Our results show that α-synuclein aggregates are excreted in stool and can be measured using the sFIDA assay, which could support the diagnosis of prodromal synucleinopathies.
Immunological correlates of protection following vaccination with glucan particles containing Cryptococcus neoformans chitin deacetylases
Authors: Wang Ruiying , Oliveira Lorena V. N. , Lourenco Diana , Gomez Christina L. , Lee Chrono K. , Hester Maureen M. , Mou Zhongming , Ostroff Gary R. , Specht Charles A. , Levitz Stuart M. 
Published: February 2023

AbstractVaccination with glucan particles (GP) containing the Cryptococcus neoformans chitin deacetylases Cda1 and Cda2 protect mice against experimental cryptococcosis. Here, immunological correlates of vaccine-mediated protection were explored. Studies comparing knockout and wild-type mice demonstrated CD4+ T cells are crucial, while B cells and CD8+ T cells are dispensable. Protection was abolished following CD4+ T cell depletion during either vaccination or infection but was retained if CD4+ T cells were only partially depleted. Vaccination elicited systemic and durable antigen-specific immune responses in peripheral blood mononuclear cells (PBMCs), spleens, and lungs. Following vaccination and fungal challenge, robust T-helper (Th) 1 and Th17 responses were observed in the lungs. Protection was abrogated in mice congenitally deficient in interferon (IFN) γ, IFNγ receptor, interleukin (IL)-1β, IL-6, or IL-23. Thus, CD4+ T cells and specific proinflammatory cytokines are required for GP-vaccine-mediated protection. Importantly, retention of protection in the setting of partial CD4+ T depletion suggests a pathway for vaccinating at-risk immunocompromised individuals.
Stem stiffness functionality in a submerged canopy patch under oscillatory flow
Authors: Barcelona Aina , Colomer Jordi , Serra Teresa 
Published: February 2023

AbstractSeagrass canopies are coastal ecosystems that are able to modify the abiotic environment through their architectural structure. They have different structural parameters, such as plant stem stiffness, patch length and canopy density, all of which determine their overall functionality in modifying the seafloor hydrodynamics within coastal areas. To determine the interaction between hydrodynamics and the canopy structure, a set of laboratory experiments were carried out with both rigid and flexible stems for different canopy densities, patch lengths and wave frequencies. In the upper part of the canopy, flexible plants move with the flow without generating drag or producing turbulent kinetic energy, while rigid plants generate drag and produce turbulent kinetic energy. In the inner canopy layer, both types of plants behave like rigid stems and produce turbulent kinetic energy. A non-dimensional model based on the turbulent kinetic energy, the wave velocity and the plant characteristics is presented to describe the behaviour of flexible and rigid plants under an oscillating flow. Flexible plants behave in a stiffer manner under high wave frequencies than under low wave frequencies, thus making their behaviour closer to that of rigid plant stems. This difference between both canopy structures can explain their distribution in the environment, with rigid canopies being more extended in more sheltered regions while flexible plants are characteristic of more exposed regions with high flow energy.
Effects of time-restricted feeding on letrozole-induced mouse model of polycystic ovary syndrome
Authors: Ryu Ki-Jin , Park Hyuntae , Han Young In , Lee Hee Jung , Nam Seunghyun , Jeong Hye Gyeong , Kim Tak 
Published: February 2023

AbstractThe present study aimed to investigate whether time-restricted feeding (TRF) ameliorates metabolic and reproductive phenotypes in a letrozole-induced mouse model of polycystic ovary syndrome (PCOS). Sixty female C57BL/6 N mice were randomly divided into two groups according to the type of food received: either a chow or a 60% high-fat diet. Those mice were subcutaneously implanted with letrozole or placebo pellets at four weeks of age. Then, letrozole-treated mice were randomly assigned to different feeding regimens: (1) TRF for 4 h (ZT12–ZT16) or (2) ad libitum diet. After 4 weeks of dietary intervention, estrous cycles were determined with daily vaginal smear examination, and serial tail-tip blood sampling was performed at 5-min intervals for 2 h to measure the luteinizing hormone (LH) pulse frequency, amplitude, and mean LH levels in the diestrus cycle stage. Letrozole-treated mice in the ad libitum group demonstrated multiple PCOS-like phenotypes including ovulatory dysfunction, polycystic ovaries, and increased body weight, parametrial fat weight, adipocyte size and inflammation, and higher expression of Cyp17, Cyp19, and Fshr in the ovary, and Kiss1r and Gnrh in the hypothalamus, elevated serum testosterone levels, and more rapid and elevated LH pulsatility, with increased pulse frequency, amplitude, and mean levels in the diestrus stage, compared with the controls. After TRF for 4 weeks, those phenotypes reverted to normal levels in letrozole-treated mice, except the percentage of diestrus cycles indicating the arrest of estrous cycling which did not differ between the TRF and ad libitum groups. Our results demonstrate that TRF has therapeutic effects on the reproductive and metabolic phenotypes of a letrozole-induced mouse model of PCOS.