bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two Illustrated Horoscopes of the Italian Renaissance
Authors: Gandolfi Giangiacomo 
Published: June 2023

Abstract
Among astral representations in Renaissance paintings and frescoes, a particular and very complex class stands out: that of Illustrated Horoscopes, that is, complete charts disguised under the cover of innocent pastoral landscapes or conventional mythological scenes. Two examples pertaining to this elusive class are proposed and analyzed in this article. The first is a Giorgionesque painting in the Royal Gallery in Dresden, the so-called Horoscope, that probably portrays the casting of a birth-chart for Ercole II d’Este, the son of Lucrezia Borgia, and at the same time a scene from the epic of Orlando and the Paladins. The second is Zucchi’s Assembly of the Gods, a copper panel painted for Ferdinando de Medici’s studiolo in the Roman Villa Medici, which arranges the planetary divinities in correlation to the zodiacal constellations, building the extraordinary nativity of the owner. Both astrological charts, albeit veiled and ambiguous by nature, are substantiated by internal signals, verified on the basis of contemporary horoscopes, and justified by the overall painting narrative.
Cartographies of Belonging: Reflections on Indigeneity and Autochthony
Authors: Cachoian-Schanz Deanna 
Published: June 2023

Abstract
This creative nonfiction reflects upon the political utility of the terms “indigeneity” and “autochthony” to describe human (and non-human) groups as genealogically bound to or originally springing from singular geographies. What do these terms reinscribe, and what might attachments to them foreclose to the Armenian, and more broadly, to the collective human experience? This mix of text and image is a plea to move beyond an “autochthonous” logic that naturalizes the coupling of bodies to lands to account, instead, for a more just and capacious understanding of existence as by, through, and for the in/animate “other” across multiple geographies and timescapes.
Effects of Different Exercise Modes on Gait Performance of Parkinson’s Disease Patients: A Systematic Review and Network Meta-Analysis
Authors: Zhang Shi-kun , Gu Mei-ling , Xu Hong , Zhou Wen-sheng , Mao Su-jie , Yang Yong 
Published: June 2023

Gait disturbances are among the main symptoms of Parkinson’s disease (PD) and can increase fall risk. In this study we aimed to systematically evaluate the effects of different exercise modes on gait indexes of PD patients. We conducted a review and network meta-analysis of randomized controlled trials in studies listed in Web of Science, MEDLINE, EMBASE, PsycINFO, Cochrane Library, ClinicalTrailS.gov , and China National Knowledge Infrastructure databases from their inception to October 23, 2021. Eligible studies were randomized controlled trials investigating the effect of exercise on gait index by using the Timed Up and Go test, (TUG), stride length, stride cadence, or 6 Minutes Walking Test (6MWT). We used Review Manager 5.3 to evaluate the quality of the included literature, and we used Stata 15.1 and R-Studio for the network meta-analysis. We assessed the relative ranking of therapies by the surface under the cumulative ranking possibilities. In 159 studies, there were 24 exercise interventions. Compared with the control group, 13 exercises showed significant improvements on the TUG; six exercises were significantly better for improving stride length; only one exercise was better for improving stride cadence; and four exercises were better for improving the 6MWT. The surface under the cumulative ranking curves suggested that Pilates, body weight support treadmill training, resistance training, and a multidisciplinary exercise program were preferable for gains on TUG, stride length, stride cadence, and 6MWT. This meta-analytic review found that exercise therapies bring obvious benefits to gait indexes of patients with PD, and the efficacy of exercise therapies varied with different types of exercise and outcome indexes.
Closed-Form Solution of the Unit Normal Loss Integral in 2 Dimensions, with Application in Value-of-Information Analysis
Authors: Yoon Lee Tae , Gustafson Paul , Sadatsafavi Mohsen ,   for the Canadian Respiratory Research Network
Published: June 2023

The unit normal loss integral (UNLI) has wide applicability in decision analysis and risk modeling, including as a solution for computation of various value-of-information (VoI) metrics. However, one limitation of the UNLI has been that its closed-form solution is available for only 1 dimension and thus can only be used for comparisons involving 2 strategies (where it is applied to the scalar incremental net benefit). We derived a closed-form solution for the 2-dimensional UNLI by the integration by parts technique. This enables the extension of the UNLI method to 3-comparison problems. We implemented this approach in R as part of the predtools package ( https://github.com/resplab/predtools/ ) and verified the accuracy of this implementation via Monte Carlo simulations. A case study based on a 3-arm clinical trial was used as an example for VoI analysis. Methods based on the closed-form solutions for the UNLI can now be extended to 3-decision comparisons, taking a fraction of a second to compute and not being subject to Monte Carlo error. Highlights The unit normal loss integral (UNLI) is widely used in decision analysis and risk modeling, including in the computation of various value-of-information metrics, but its closed-form solution is only applicable to comparisons of 2 strategies. We derive a closed-form solution for 2-dimensional UNLI, extending the applicability of the UNLI to 3-strategy comparisons. Such closed-form computation takes only a fraction of a second and is free from simulation errors that affect the hitherto available methods. In addition to the relevance in 3-strategy model-based and data-driven decision analyses, a particular application is in risk prediction modeling, where the net benefit of a classifier should always be compared with 2 default strategies of treating none and treating all.
Incidence, Racial Disparities and Factors Related to Psychosis among Black Individuals in Canada: A Scoping Review
Authors: Cénat Jude Mary , Dromer Élisabeth , Darius Wina Paul , Dalexis Rose Darly , Furyk Sarah Elizabeth , Poisson Hannah , Mansoub Bekarkhanech Farid , Diao David Guangyu , Gedeon Andi Phaelle , Shah Muhammad S. , Labelle Patrick R. , Bernheim Emmanuelle , Kogan Cary S. 
Published: June 2023

Objective Black communities are increasingly concerned about psychosis, a worry echoed by provincial health-care systems across Canada. Responding to the lack of evidence on psychosis in Black communities, this scoping review examined the incidence and prevalence of psychosis, access to care (pathways to care, coercive referrals, interventions, etc.), treatments received, and stigma faced by individuals with psychosis. Method To identify studies, a comprehensive search strategy was developed and executed in December 2021 across 10 databases, including APA PsycInfo, CINAHL, MEDLINE and Web of Science. Subject headings and keywords relating to Black communities, psychosis, health inequalities, Canada and its provinces and territories were used and combined. The scoping review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping review (PRISMA-ScR) reporting standard. Results A total of 15 studies met the inclusion criteria, all of them conducted in Ontario and Quebec. Results highlight different disparities in psychosis among Black communities. Compared to other Canadian ethnic groups, Black individuals are more likely to be diagnosed with psychosis. Black individuals with psychosis are more likely to have their first contact with health-care settings through emergency departments, to be referred by police and ambulance services, and to experience coercive referrals and interventions, and involuntary admission. Black individuals experience a lower quality of care and are the ethnic group most likely to disengage from treatment. Conclusion This scoping review reveals many gaps in research, prevention, promotion and intervention on psychosis in Black individuals in Canada. Future studies should explore factors related to age, gender, social and economic factors, interpersonal, institutional and systemic racism, and psychosis-related stigma. Efforts should be directed toward developing trainings for health-care professionals and promotion and prevention programs within Black communities. Culturally adapted interventions, racially disaggregated data, and increased research funding are needed.
Caregiver Experiences Participating in a Home-Based Primary Care Program: A Pragmatic Evaluation Including Qualitative Interviews and Quantitative Surveys
Authors: Kling Samantha M. R. , Lessios Anna Sophia , Holdsworth Laura M. , Yefimova Maria , Wu Siqi , Martin Marina , Sheffrin Meera , Winget Marcy 
Published: June 2023

The aim of this evaluation was to assess caregiver experience and burden during their first year in a geriatric home-based primary care (HBPC) program with qualitative interviews and surveys. HBPC included in-home visits for homebound, older adult patients. Seventeen caregivers, with varied amount of experience with HBPC, participated in semi-structured interviews. Change in caregiver burden from baseline was captured for 44 caregivers at 3 months post-enrollment, 27 caregivers at 6 months, and 22 caregivers at 12 months. Satisfaction survey was administered at these timepoints, but the last response of 48 caregivers was analyzed. Caregiver interviews revealed three themes: caregiving stressors, reliance on HBPC in relation to other medical care, and healthcare in the home. Surveyed caregivers were highly satisfied, but burden did not change substantially over the 1 year intervention. Caregivers appreciated HBPC reduced patient transportation and provided satisfactory primary care, but additional research is needed to tailor this care to reduce caregiver burden.
Diabetes mellitus care cascade among a cohort of persons living with HIV and hypertension in Uganda: A retrospective cohort study
Authors: Ambangira Fortunate , Sharman James E , Muddu Martin , Kimera Isaac Derick , Namara Daphine , Musimbaggo Douglas Joseph , Namugenyi Christabellah , Ssenyonjo Rebecca , Mbuliro Mary , Katwesigye Rodgers , Schwartz Jeremy I , Semitala Fred Collins , Ssinabulya Isaac 
Published: June 2023

Background In Uganda, it is recommended that persons with HIV receive integrated care to address both hypertension and diabetes. However, the extent to which appropriate diabetes care is delivered remains unknown and was the aim of this study. Methods We conducted a retrospective study among participants receiving integrated care for HIV and hypertension for at least 1 year at a large urban HIV clinic in Mulago, Uganda to determine the diabetes care cascade. Results Of the 1115 participants, the majority were female ( n = 697, 62.5%) with a median age of 50 years (Inter Quartile Range: 43, 56). Six hundred twenty-seven participants (56%) were screened for diabetes mellitus, 100 (16%) were diagnosed and almost all that were diagnosed ( n = 94, 94%) were initiated on treatment. Eighty-five patients (90%) were retained and all were monitored (100%) in care. Thirty-two patients (32/85, 38%) had glycaemic control. Patients on a Dolutegravir-based regimen (OR = 0.31, 95% CI = 0.22-0.46, p < 0.001) and those with a non-suppressed viral load (OR = 0.24, 95% CI = 0.07-0.83, p = 0.02) were less likely to be screened for diabetes mellitus. Conclusions In very successful HIV care programs, large gaps still linger for the management of non-communicable diseases necessitating uniquely designed intervention by local authorities and implementing partners addressing the dual HIV and non-communicable diseases burden.
Super-thin anterolateral thigh flap for reconstruction of the medial plantar artery perforator flap donor site
Authors: Zhou Jian-dong , Zhang Xing-fei , Xu Tong-long , Yang Wen-bo , Xu Ya-jun 
Published: June 2023

Background The medial plantar artery perforator (MPAP) flap is widely used to reconstruct the weight-bearing area of the foot. Traditionally, its donor site is closed using a skin graft, which is associated with several complications, including walking disability. This study aimed to examine our experience with using a super-thin anterolateral thigh (ALT) flap to reconstruct the MPAP flap donor site. Methods We examined 10 patients who underwent reconstruction of the MPAP flap donor site using a super-thin ALT flap between August 2019 and March 2021. The vascular pedicle was anastomosed to the proximal end of the medial plantar vessels or the end of the posterior tibial vessels. Results All reconstruction flaps survived and all patients were satisfied with the aesthetic appearance. No blisters, ulcerations, hyperpigmentation, or contractures occurred. All patients gained protective sensation in the super-thin ALT flap. The average visual analog scale score for the aesthetic appearance of the reconstructed foot was 8.5 ± 0.7 (range, 8–10). All patients were able to ambulate without aids and could wear regular shoes. The average revised Foot Function Index score was 26.4 ± 4.1 (range, 22–34). Conclusion Reconstruction of the MPAP flap donor site using a super-thin ALT flap is reliable and provides satisfactory functional recovery, aesthetic appearance, and protective sensation while minimizing postoperative morbidity.
Sodium Phenylbutyrate and Taurursodiol: A New Therapeutic Option for the Treatment of Amyotrophic Lateral Sclerosis
Authors: Alqallaf Ali , Cates Drew W. , Render Kandon P. , Patel Katie A. 
Published: June 2023

Objective: To review the safety and efficacy of sodium phenylbutyrate and taurursodiol (SP + T) in slowing progression of amyotrophic lateral sclerosis (ALS) compared with pre-existing therapies. Data Sources: A PubMed (from January 1, 2009, to April 13, 2023) and ClinicalTrials.gov search conducted using sodium phenylbutyrate, taurursodiol, AMX0035, riluzole, and edaravone. Additional articles were identified by hand from references. Data Selection and Data Extraction: This included English-language articles evaluating SP + T efficacy or safety in humans for decreasing neuronal death and slowing the progression of ALS. Data Synthesis: In one phase II clinical trial that encompassed an open-label extension phase, disease severity, assessed by the rate of decline in overall score on the Amyotrophic Lateral Sclerosis Functional Rating Scale–Revised with higher scores indicating more functional ability, was –1.24 points per month with active drug and –1.66 points per month with placebo (difference, 0.42 points per month; 95% CI, 0.03-0.81; P = 0.03). Post hoc analysis found survival benefit of median 4.8 months with active medication compared with placebo. Relevance to Patient Care and Clinical Practice in Comparison With Existing Drugs: SP + T is a new US Food and Drug Administration–approved oral suspension for the treatment of ALS. Patients who received active medication through the phase II trial showed decreased rates of disease progression. Overall, SP + T could be considered a potential agent for the treatment of ALS which has a high unmet need. Conclusion: SP + T is an option for the treatment of ALS; however, additional data regarding efficacy in phase III trials with long-term safety profile considerations, as well as trials to compare current therapy with SP + T, are needed.
Remote Administration of ADHD-Sensitive Cognitive Tasks: A Pilot Study
Authors: Sun Shaoxiong , Denyer Hayley , Sankesara Heet , Deng Qigang , Ranjan Yatharth , Conde Pauline , Rashid Zulqarnain , Bendayan Rebecca , Asherson Philip , Bilbow Andrea , Groom Madeleine , Hollis Chris , Folarin Amos A. , Dobson Richard J. B. , Kuntsi Jonna 
Published: June 2023

Objective: We assessed the feasibility and validity of remote researcher-led administration and self-administration of modified versions of two cognitive tasks sensitive to ADHD, a four-choice reaction time task (Fast task) and a combined Continuous Performance Test/Go No-Go task (CPT/GNG), through a new remote measurement technology system. Method: We compared the cognitive performance measures (mean and variability of reaction times (MRT, RTV), omission errors (OE) and commission errors (CE)) at a remote baseline researcher-led administration and three remote self-administration sessions between participants with and without ADHD ( n = 40). Results: The most consistent group differences were found for RTV, MRT and CE at the baseline researcher-led administration and the first self-administration, with 8 of the 10 comparisons statistically significant and all comparisons indicating medium to large effect sizes. Conclusion: Remote administration of cognitive tasks successfully captured the difficulties with response inhibition and regulation of attention, supporting the feasibility and validity of remote assessments.
Salivary Interleukin 1-Beta Concentration Associates With Sleep Quality in Older Individuals
Authors: Ibáñez-del Valle Vanessa , Ballestar-Tarín Maria Luisa , Mafla-España Mayra Alejandra , Cauli Omar , Navarro-Martínez Rut 
Published: June 2023

Background: Poor sleep quality is prevalent in older people and impairs their quality of life. Various studies show an association between sleep disorders and altered levels of inflammatory cytokines. The cytokine IL-1β has been shown to display both somnogenic and insomnia-promoting effects in experimental animals. Objectives: to evaluate the relationship between insomnia and salivary IL-1β concentration and the role of associated factors such as the symptoms of depression, use of hypnotics, intake of caffeinated beverages, smoking, and alcohol use in older individuals. An analytical, cross-sectional, observational research was carried out with a population of community-dwelling individuals over 60 years of age in Valencia (Spain). Sleep quality was measured with the Athens insomnia scale (AIS) and depressive symptoms with Geriatric Depression Scale (GDS). Results: 287 individuals participated in the study (mean age 74.08 years (76.7% women). 41.5% of the participants had insomnia, 36.9% took drugs for sleep problems, and 32.4% had relevant depressive symptoms. There was a significant inverse correlation between the IL-1β and total AIS score (rho = −0.302, p < 0.001), the sleep difficulty subdomain (rho = −0.259, p < 0.001), and the daytime sleepiness subdomain (rho = −0.322, p < 0.001). No significant correlation was observed between GDS and salivary IL-1β concentration. The IL-1β concentration was significantly lower in individuals taking drugs for sleeping compared with those not taking those drugs (1.11 ± 0.09 and 1.48 ± 0.08, respectively; p = 0.001). Regarding the AIS score, there was no significant difference in marital status, smoking, or the number of cups of tea or cola drinks, but there was a significant association with alcohol intake ( p = 0.019) and in the number of daily intakes of coffee ( p = 0.030). The receiver operating characteristic (ROC) curve analysis of IL-1β for diagnosis of moderate-severe insomnia showed an area under the curve (AUC) value of 0.78 (95% confidence interval 0.71–0.85). At the cut-off of 0.83 pg/µL of Il-1β, it had a sensitivity of 70.3% and a specificity of 69.8%.
Effect of occlusal hypofunction on centre of resistance in maxillary central incisor using the finite element method
Authors: Kuharattanachai Kachaphol , Jotikasthira Dhirawat , Rangsri Wetchayan , Tripuwabhrut Kanich 
Published: June 2023

Objectives: To determine differences in the location of centre of resistance (Cres) between functional and hypofunctional teeth and to evaluate the relationship between the pulp cavity volume and locations of the Cres, using the finite element (FE) method. Design: Retrospective cohort study. Participants: FE models of right maxillary central incisor, derived from cone-beam computed tomography (CBCT) images of 46 participants, were divided into normal function (n = 23) and hypofunction (n = 23) groups using anterior overbite and cephalometric measurements. Methods: Measurements of the tooth and pulp cavity volume were made from the CBCT. Cres levels were presented as percentages of the root length from the root’s apex. All data were analysed and compared using the independent t-test ( P < 0.05). The relationship between the location of Cres and volume ratios were evaluated statistically. Results: The means of the pulp cavity/tooth volume and root canal/ root volume ratio of the maxillary central incisor in the anterior open bite group were significantly greater than those in the normal group. The average location of Cres in the anterior open bite group was 0.6 mm (3.7%) apically from the normal group, measured from root apex. The difference was statistically significant ( P < 0.01). There was a significant correlation between root canal/root volume ratio and locations of Cres (r = −0.780, P < 0.001). Conclusions: The Cres in the hypofunctional group was located more apical than the functional group. As the pulp cavity volume increased, the level of Cres shifted apically.
Structural Integrity of the Cerebellar Outflow Tract Predicts Long-Term Motor Function After Middle Cerebral Artery Ischemic Stroke
Authors: Yoo Yeun Jie , Lim Seong Hoon , Kim Youngkook , Kim Joon-Sung , Hong Bo Young , Yoon Mi-Jeong , Rim Hanee , Park Geun-Young 
Published: June 2023

Background The cerebellum plays a crucial role in functional movement by influencing sensorimotor coordination and learning. However, the effects of cortico-cerebellar connectivity on the recovery of upper extremity motor function after stroke have not been investigated. We hypothesized that the integrity of the cortico-cerebellar connections would be reduced in patients with a subacute middle cerebral artery (MCA) stroke, and that this reduction may help to predict chronic upper extremity motor function. Methods We retrospectively analyzed the diffusion-tensor imaging of 25 patients with a subacute MCA stroke (mean age: 62.2 ± 2.7 years; 14 females) and 25 age- and sex-matched healthy controls. We evaluated the microstructural integrity of the corticospinal tract (CST), dentatothalamocortical tract (DTCT), and corticopontocerebellar tract (CPCT). Furthermore, we created linear regression models to predict chronic upper extremity motor function based on the structural integrity of each tract. Results In stroke patients, the affected DTCT and CST showed significantly impaired structural integrity compared to unaffected tracts and the tracts in controls. When all models were compared, the model that used the fractional anisotropy (FA) asymmetry indices of CST and DTCT as independent variables best predicted chronic upper extremity motor function ( R2 = .506, P = .001). The extent of structural integrity of the CPCT did not significantly differ between hemispheres or groups and was not predictive of motor function. Conclusions We found evidence that microstructural integrity of the DTCT in the subacute phase of an MCA stroke helped to predict chronic upper extremity motor function, independent of CST status.