bluuebunny/crossref_metadata_2025_split huggingface dataset:
Job exposure matrices for occupational respiratory disease: a narrative review
Authors: Huntley C C , Bhomra P , Walters G I 
Published: May 2023

Abstract

Background
Job exposure matrices (JEMs) are epidemiological tools used to provide estimations of occupational exposures when it is not feasible to complete detailed individual occupational histories.

Aims
To identify and summarize the characteristics of published general population JEMs (GPJEM) of inhalable occupational exposures applied in studies of respiratory disease.

Methods
MEDLINE and EMBASE databases were searched using pre-defined search terms, with screening performed by two independent reviewers to identify studies reporting the use of a GPJEM. JEM creation papers were subsequently identified and reviewed for each individual GPJEM, noting its characteristics in terms of occupational classification system and exposure estimates.

Results
From 728 studies identified in initial searches, 33 GPJEMs of inhalable occupational exposures were identified. Versions of the International Standards Classification of Occupations were the most used occupational classification system. Binary, probability and intensity-based exposure estimates were most frequently reported in GPJEMs.

Conclusions
Selection of a GPJEM to apply in epidemiological research should be based on the exposure(s) of interest, time period of occupations under review, geographical region for intended use, occupation classification system used and the exposure estimate outcome.
Targeting of plasmodesmal proteins requires unconventional signals
Authors: Luna Gabriel Robles , Li Jiefu , Wang Xu , Liao Li , Lee Jung-Youn 
Published: May 2023

Abstract
Effective cellular signaling relies on precise spatial localization and dynamic interactions among proteins in specific subcellular compartments or niches, such as cell-to-cell contact sites and junctions. In plants, endogenous and pathogenic proteins gained the ability to target plasmodesmata, membrane-lined cytoplasmic connections, through evolution to regulate or exploit cellular signaling across cell wall boundaries. For example, the receptor-like membrane protein PLASMODESMATA-LOCATED PROTEIN 5 (PDLP5), a potent regulator of plasmodesmal permeability, generates feed-forward or feed-back signals important for plant immunity and root development. However, the molecular features that determine the plasmodesmal association of PDLP5 or other proteins remain largely unknown, and no protein motifs have been identified as plasmodesmal targeting signals. Here, we developed an approach combining custom-built machine-learning algorithms and targeted mutagenesis to examine PDLP5 in Arabidopsis thaliana and Nicotiana benthamiana. We report that PDLP5 and its closely related proteins carry unconventional targeting signals consisting of short stretches of amino acids. PDLP5 contains 2 divergent, tandemly arranged signals, either of which is sufficient for localization and biological function in regulating viral movement through plasmodesmata. Notably, plasmodesmal targeting signals exhibit little sequence conservation but are located similarly proximal to the membrane. These features appear to be a common theme in plasmodesmal targeting.
The longitudinal study of muscle changes with ultrasound: differential changes in idiopathic inflammatory myopathy subgroups
Authors: Paramalingam Shereen , Needham Merrilee , Bulsara Max , Mastaglia Frank L , Keen Helen I 
Published: May 2023

Abstract

Objectives
We investigated shear wave elastography (SWE), B mode US and power Doppler (PDUS) as imaging biomarkers for longitudinal follow-up in idiopathic inflammatory myopathy (IIM), with a particular focus on immune-mediated necrotizing myopathy (IMNM) and DM.

Methods
Participants had serial SWE, PDUS on the deltoid (D) and vastus lateralis (VL) muscles on four occasions at intervals of 3–6 months. Clinical assessments included manual muscle testing, and patient- and physician-reported outcome scales.

Results
Thirty-three participants were included: IMNM = 17, DM = 12, overlap myositis = 3, PM = 1. Twenty were in a prevalent clinic group, and 13 were recently treated cases in an incident group. Differential changes in SWS and US domains occurred with time in both the prevalent and incident groups. In the VL-prevalent subgroup, echogenicity increased over time (P = 0.040), while in the incident cases there was a trend for reduction to normal over time (P = 0.097) with treatment. Muscle bulk reduced in the D-prevalent subgroup over time (P = 0.096), suggesting atrophy. SWS also reduced in the VL-incident subgroup over time (P = 0.096), suggesting a trend towards improvement in muscle stiffness with treatment.

Conclusion
SWE and US appear promising as imaging biomarkers for patient follow-up in IIM and indicate changes over time, especially with echogenicity, muscle bulk and SWS in the VL. Due to the limitations of the participant numbers, additional studies with a larger cohort are needed to help evaluate these US domains further and outline specific characteristics within the IIM subgroups.
A teaching concept for school experiments on radioactivity using augmented reality methods
Authors: Schuette Charlotte , Streuber Marcus , Pottgiesser Vivien , Preim Bernhard , Saalfeld Patrick , Vahlbruch Jan-Willem , Walther Clemens 
Published: May 2023

Abstract
Digital media are becoming increasingly influential in society, especially among the younger generation. Therefore, an augmented reality (AR) app was developed that simulates experiments with radioactive sources. The app runs experiments on the range and penetration power of alpha, beta and gamma radiation. It assigns virtual radiation sources, shielding materials or a detector to printed image markers, and superimposes their 3D images on the camera image. Alpha, beta and gamma radiation are clearly distinguishable by choosing different visualizations. The detector displays the measured count rates. At school, the app can be used in different ways. A concept for a teaching unit in Grade 10 was developed and tested in several classes based on a prototype of the app. The learning progress from the AR experiments was examined. Furthermore, an evaluation of the app was carried out. The most recent version of the app can be found here: https://seafile.projekt.uni-hannover.de/d/dd033aaaf5df4ec18362/
Experiences with accreditation for radon measurement laboratories
Authors: Wiedner Hannah , Rupp Christian 
Published: May 2023

Abstract
The adoption of the Council Directive 2013/59/EURATOM into Austrian national law generated new challenges for businesses, authorities and measurement services. The law defines radon priority regions in which all employers are obliged to hire an authorised radon-monitoring service to determine radon activity concentration at workplaces in basements and on ground floors. In this paper, an overview of our experiences with the process of becoming an accredited and authorised radon-monitoring body using integrating and time-resolved radon measurement equipment is given. The main challenges to overcome, such as determination of measurement uncertainty, conducting metrologically traceable calibration of the track-etch detector system, information not covered by ISO 11665-1, ISO 11665-4 and ISO 11665-5, availability of proficiency tests, etc., are described. This paper aims to be a guideline for laboratories seeking accreditation in the field of radon activity concentration measurements.
Information on cosmic radiation received by Belgian aircrew: a survey
Authors: Pepin Stéphane , Fremout An , Leonard Sophie , Radulovic Sarah , Vanaudenhove Thibault 
Published: May 2023

Abstract
Exposure of aircrew to cosmic radiation had already been identified as an issue of concern in the European BSS of 1996 which requested airlines to assess the exposure of the crew and to inform their workers of the health risks their work involves. These requirements have been implemented in Belgian regulations in 2001 and updated with the transposition of the 2013/59/Euratom directive. Dosimetry data show that aircrew is the group of workers, which contributes the most to the collective dose of occupationally exposed workers in Belgium. In order to verify the extent of the information received by Belgian aircrew regarding their exposure to cosmic radiation, FANC, the Belgian radiation protection authority, launched in 2019 a large survey in collaboration with the Belgian Cockpit Association (BeCA), the professional association representing airline pilots in Belgium. The survey included 8 questions regarding the information of aircrew on cosmic radiation in general, on the individual dose level and on the risk related to exposure during pregnancy. A total of about 400 responses to the survey were received. Overall, the survey reveals that aircrew members in Belgium receive too little information about the potential risks, that they are not sufficiently informed about their own exposure and that female staff members are insufficiently informed about the hazards for the unborn child in case of pregnancy, and 66% of the respondents answered that their employer has never informed them about their exposure to cosmic radiation. However, most are aware of this phenomenon, either because they have looked up information or because they have discussed the topic with colleagues and professional associations. The results also showed that 17% of female crew continued to fly while being pregnant. Finally, the survey also allowed to identify differences and similarities between different groups of workers: cockpit and cabin crew, men and women. For instance, cabin crew was even less informed about their individual exposure than cockpit crew.
Simple one-parameter function to retrieve the correct exposure value from CR-39 radon detectors in high-saturation regime. Checks on two kinds of analysis systems
Authors: Marchese Rocco , Nicolino Antonella , Palma Achille , Procopio Salvatore 
Published: May 2023

Abstract
Radon activity concentration measurements in air can be easily performed by using CR-39 detectors whose response is almost linear in the range of medium–low exposures. However, when the exposure values grow too much, a saturation phenomenon becomes relevant and some corrections have to be adopted even if they cannot always be very accurate and easy to apply. Therefore, a simple alternative method for determining the correct response curve of the CR-39 detectors, from low up to very high radon exposures, is showed. To verify its robustness and the general applicability, several certified measurements were carried out in a radon chamber at different levels of exposure. Moreover, two different types of commercially available radon analysis systems were used.
Public exposure to artificial optical radiation in the aesthetics and the entertainment sector in Greece. Risk management actions
Authors: Petri Aspasia , Karabetsos Efthymios 
Published: May 2023

Abstract
Safety issues are raised from the use of low- and high-power optical radiation sources, both laser and non-laser, by non-experts for aesthetic and entertainment purposes. The Greek Atomic Energy Commission relied on the ISO 31000:2018 framework to manage the public exposure risk to such cases. Risk was evaluated as (1) intolerable for lasers and intense pulsed light sources at aesthetic procedures and in the case of laser pointers, (2) severe for lasers at laser shows and (3) moderate for light-emitting diodes (LEDs) at aesthetic procedures, home-use intense pulsed light sources/LEDs and laser/LED projectors. Operators’ training, public awareness campaigns, intensive market surveillance actions and the enhancement of the regulatory framework have been proposed as risk treatment/control measures and have been prioritised in this order, according to their effectiveness in reducing the exposure risk and their urgency of implementation. The Greek Atomic Energy Commission developed public awareness campaigns regarding exposure safety to laser and non-laser light sources at aesthetic procedures and the use of laser pointers.
Operational radiation protection challenges for the LHC experiments
Authors: Bozzato Davide , Froeschl Robert , Kouskoura Vasiliki 
Published: May 2023

Abstract
Radiation protection physicists at CERN are often required to assess residual activation for the Large Hadron Collider (LHC) experiments during stop periods in order to ensure adequate optimization during planned exposure situations and to establish proper procedures for the radiological control of materials. Given the complexity of the facilities and of the high-energy and mixed fields inducing the activation, Monte Carlo transport codes are an essential tool to simulate both prompt and residual radiation. The present work highlights the challenges of assessing residual dose rates for the LHC experiments in shutdown configurations and of establishing residual activation zonings. For the latter, a method based on fluence conversion coefficients was developed and is efficiently employed. The practical example of the assessment of the activation of the 600 tons of austenitic stainless steel in the future Compact Muon Solenoid (CMS) High Granularity Calorimeter will be used to demonstrate how these challenges are dealt with and the capabilities of the method developed.
The European NORM Association (ENA)—promoting radiation protection in the field of norm in Europe
Authors: Gellermann Rainer , Ahrens Christian , Friedreich Susanne , Kunze Christian , Pepin Stéphane , Van Bochove Lonneke , Wiegers Rob 
Published: May 2023

Abstract
The European NORM Association (ENA) was founded in 2017, merging previously informal European networks. It has the statute of an International Non-profit Organization established under Belgian Law. The objective of ENA is to promote and advance radiation protection in the context of exposure to NORM. It operates as a European platform and forum for discussion, dissemination and exchange of information, training and education and by supporting scientific knowledge and new directions of research related to NORM issues. A key activity of ENA is to share practical solutions. To this end, ENA gathers radiation protection practitioners, regulators, scientists and industry representatives in order to support the management of NORM in compliance with European standards and according to best practices. Since its foundation, ENA has organized three workshops where topical issues on NORM have been discussed. It has established close working relationships and links with IAEA, HERCA, IRPA and other international initiatives—getting a recognition at international level. ENA has set up working groups on NORM in the industry, in the environment, in building materials and, as recently as in 2021, a working group on decommissioning of NORM facilities. A series of webinars have been organized to present case studies on NORM decommissioning and discuss associated challenges and practical solutions.
Aspirin Noninferior to Low-Molecular-Weight Heparin for Thromboprophylaxis After Fracture
Authors: Rosenberg Karen 
Published: May 2023

According to this study:

Thromboprophylaxis with aspirin was noninferior to low-molecular-weight heparin for preventing fatal events in patients with orthopedic trauma.The incidence of deep vein thrombosis, pulmonary embolism, and death at 90 days was low in both groups.
Direct oral anticoagulant drugs for the management of venous thromboembolism
Authors: Thanavaro Joanne L. 
Published: May 2023

Abstract:
Direct oral anticoagulants (DOACs) are effective for both prevention and treatment of venous thromboembolism (VTE) and have favorable safety in comparison with warfarin. Although drug-drug interactions with DOACs are not as frequent as with warfarin, certain drugs can interfere with DOAC metabolism, affect DOAC efficacy, and potentially cause adverse reactions when used in combination with DOACs. The NP must determine which agent is most beneficial for the individual patient with VTE based on a number of factors. A knowledge of periprocedural management of DOACs will assist the NP in providing a smooth transition for patients undergoing minor and major procedures and surgeries.
Performance of ChatGPT on the pharmacist licensing examination in Taiwan
Authors: Wang Ying-Mei , Shen Hung-Wei , Chen Tzeng-Ji 
Published: May 2023

Background:
ChatGPT is an artificial intelligence model trained for conversations. ChatGPT has been widely applied in general medical education and cardiology, but its application in pharmacy has been lacking. This study examined the accuracy of ChatGPT on the Taiwanese Pharmacist Licensing Examination and investigated its potential role in pharmacy education.

Methods:
ChatGPT was used on the first Taiwanese Pharmacist Licensing Examination in 2023 in Mandarin and English. The questions were entered manually one by one. Graphical questions, chemical formulae, and tables were excluded. Textual questions were scored according to the number of correct answers. Chart question scores were determined by multiplying the number and the correct rate of text questions. This study was conducted from March 5 to March 10, 2023, by using ChatGPT 3.5.

Results:
The correct rate of ChatGPT in Chinese and English questions was 54.4% and 56.9% in the first stage, and 53.8% and 67.6% in the second stage. On the Chinese test, only pharmacology and pharmacochemistry sections received passing scores. The English test scores were higher than the Chinese test scores across all subjects and were significantly higher in dispensing pharmacy and clinical pharmacy as well as therapeutics.

Conclusion:
ChatGPT 3.5 failed the Taiwanese Pharmacist Licensing Examination. Although it is not able to pass the examination, it can be improved quickly through deep learning. It reminds us that we should not only use multiple-choice questions to assess a pharmacist’s ability, but also use more variety of evaluations in the future. Pharmacy education should be changed in line with the examination, and students must be able to use AI technology for self-learning. More importantly, we need to help students develop humanistic qualities and strengthen their ability to interact with patients, so that they can become warm-hearted healthcare professionals.
Reassessing the survival benefit of deceased donor liver transplantation – retrospective cohort study
Authors: Malamon John S. , Kaplan Bruce , Jackson Whitney E. , Saben Jessica L. , Schold Jesse D. , Pomfret Elizabeth A. , Pomposelli James J. 
Published: May 2023

Introduction:
Currently in the United States, deceased donor liver transplant (DDLT) allocation priority is based on the Model for End-Stage Liver Disease including sodium (MELD-Na) score. The United Network for Organ Sharing’s “Share-15” policy states that candidates with MELD-Na scores of 15 or greater have priority to receive local organ offers compared to candidates with lower MELD-Na scores. Since the inception of this policy, major changes in the primary etiologies of end-stage liver disease have occurred and previous assumptions need to be recalibrated.

Methods:
We retrospectively analyzed the Scientific Registry of Transplant Recipients database between 2012 and 2021 to determine life years saved by DDLT at each interval of MELD-Na score and the time-to-equal risk and time-to-equal survival versus remaining on the waitlist. We stratified our analysis by MELD exception points, primary disease etiology, and MELD score.

Results:
On aggregate, compared to remaining on the waitlist, a significant one-year survival advantage of DDLT at MELD-Na scores as low as 12 was found. The median life-years saved at this score after liver transplant was estimated to be greater than 9 years. While the total life years saved were comparable across all MELD-Na scores, the time-to-equal risk and time-to-equal survival decreased exponentially as MELD-Na scores increased.

Conclusion:
Herein we challenge the perception as to the timing of DDLT and when that benefit occurs. National liver allocation policy is transitioning to a continuous distribution framework and these data will be instrumental to defining the attributes of the continuos allocation score.
Significance of Shear Wave Dispersion Slope Values Before Versus After Biliary Drainage in Patients With Obstructive Jaundice
Authors: Sugiura Ryo , Kuwatani Masaki , Nishida Mutsumi , Satoh Megumi , Kawakubo Kazumichi , Kato Shin , Hirata Koji , Nakajima Masahito , Hirata Hajime , Takishin Yunosuke , Sakamoto Naoya 
Published: May 2023

Abstract
The shear wave dispersion (SWD) slope has become available in the clinical practice and is related to tissue viscosity. However, clinical evaluation using SWD was not yet performed for obstructive jaundice. We aimed to evaluate the change of SWD values between before and after biliary drainage in patients with obstructive jaundice. This prospective observational cohort study evaluated 20 patients with obstructive jaundice who underwent biliary drainage. The SWD and liver elasticity values were measured before versus after biliary drainage, comparing between days −5 and 0 (day 0), days 1 and 3 (day 2), and days 6 and 8 (day 7). The mean ± SD values of SWD measured at day 0, day 2, and day 7 were 15.3 ± 2.7, 14.2 ± 3.3, and 13.3 ± 2.4 m/s/kHz, respectively. Dispersion slope values were decreased significantly from day 0 to day 2, from day 2 to day 7, and from day 0 to day 7 (P < 0.05). Liver elasticity levels and serum hepatobiliary enzymes were additionally decreased significantly over time after biliary drainage. The correlations between SWD and liver elasticity values were strong (r = 0.91, P < 0.01). In conclusion, the SWD values decreased significantly over time after biliary drainage concomitant with liver elasticity.
Multi-Scale Label-free Human Brain Imaging with Integrated Serial Sectioning Polarization Sensitive Optical Coherence Tomography and Two-Photon Microscopy
Authors: Chang Shuaibin , Yang Jiarui , Novoseltseva Anna , Fu Xinlei , Li Chenglin , Chen Shih-Chi , Augustinack Jean C. , Magnain Caroline , Fischl Bruce , Mckee Ann C. , Boas David A. , Chen Ichun Anderson , Wang Hui 
Published: May 2023

AbstractThe study of neurodegenerative processes in the human brain requires a comprehensive understanding of cytoarchitectonic, myeloarchitectonic, and vascular structures. Recent computational advances have enabled volumetric reconstruction of the human brain using thousands of stained slices, however, tissue distortions and loss resulting from standard histological processing have hindered deformation-free reconstruction of the human brain. The development of a multi-scale and volumetric human brain imaging technique that can measure intact brain structure would be a major technical advance. Here, we describe the development of integrated serial sectioning Polarization Sensitive Optical Coherence Tomography (PSOCT) and Two Photon Microscopy (2PM) to provide label-free multi-contrast imaging, including scattering, birefringence and autofluorescence of human brain tissue. We demonstrate that high-throughput reconstruction of 4×4×2cm3sample blocks and simple registration of PSOCT and 2PM images enable comprehensive analysis of myelin content, vascular structure, and cellular information. We show that 2μmin-plane resolution 2PM images provide microscopic validation and enrichment of the cellular information provided by the PSOCT optical property maps on the same sample, revealing the sophisticated capillary networks and lipofuscin filled cell bodies across the cortical layers. Our method is applicable to the study of a variety of pathological processes, including demyelination, cell loss, and microvascular changes in neurodegenerative diseases such as Alzheimer’s disease (AD) and Chronic Traumatic Encephalopathy (CTE).