bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between Toxoplasma gondii infection and psychiatric disorders in Iran: A systematic review with meta-analysis
Authors: Montazeri Mahbobeh , Moradi Elahe , Moosazadeh Mahmood , Hosseini Seyed Hamzeh , Fakhar Mahdi 
Published: August 2023

Background
Toxoplasma gondii, a ubiquitous parasitic protozoan, may be an important cause of neurological and psychiatric diseases. The present systematic review and meta-analysis, therefore, was conducted to investigate the scientific evidence regarding the potential association between T. gondii infection and psychiatric disorders in Iran.

Methods
We systematically reviewed articles from world-wide databases, including PubMed, Scopus, Science Direct, Web of Science, Google Scholar, and Iranian national databases up to July 30th, 2021. The Newcastle Ottawa Scale (NOS) was used to assess the quality of included studies. The common odds ratio (OR) was estimated using inverse variance and a random-effects model. Heterogeneity was assessed using the χ2-based Cochrane test (Q) and the I2 index. Also, sensitivity analyses and publication bias were calculated. Moreover, subgroup analysis was performed based on the type of disorder and quality score of different eligible studies.

Results
16 studies were included in this meta-analysis. Our meta-analyses found that the OR of the risk of anti- T. gondii IgG and IgM in psychiatric patients compared to the control group was 1.56 (95% CI; 1.23–1.99) and 1.76 (95% CI: 1.19–2.61), respectively. Subgroup analysis based on the type of disorder showed that the OR of the risk of anti- T. gondii IgG in Iranian schizophrenia patients and other psychiatric disorders compared to the control group were 1.50 (95% CI; 1.09–2.07) and 2.03 (95% CI: 1.14–3.60), respectively, which are statistically significant. Also, the OR of the risk of anti- T. gondii IgM in Iranian schizophrenia and depression patients compared to the control group was 1.54 (95% CI; 0.9–2.64) and 1.03 (95% CI: 0.2–5.24), respectively, which are not statistically significant. Additionally, subgroup analysis based on quality scores showed no significant influence on the results according to the moderate quality studies. However, this association was significant according to the high quality studies. The obtained results of Egger’s test were 1.5 (95% CI; -0.62–3.73, P = 0.15) and 0.47 (95% CI; -0.82–1.76, P = 0.45), respectively, indicating publication bias. The significant results of the heterogeneity analysis confirmed a high level of heterogeneity in the IgG test (P = 0.000, I2 = 66.6%). However, no significant results from the test of heterogeneity were detected in the IgM test (P = 0.15, I2 = 27.5%). The results of the sensitivity analysis showed that the impact of each study on the meta-analysis was not significant on overall estimates.

Conclusions
Despite the limited number of studies, these outcomes supported a possible link between T. gondii infection and psychiatric disorders in Iran. However, more high-quality investigations are needed in the future.
Prevalence and correlates associated with early childbearing among teenage girls in Ethiopia: A multilevel analysis
Authors: Liga Abebe Debu , Boyamo Adane Erango , Jabir Yasin Negash , Tereda Akalu Banbeta 
Published: August 2023

Background
Teenage childbearing remains a significant global health concern, and in nations with limited resources, it is the major cause of newborn and maternal deaths. Early teenage childbearing is still Ethiopia’s public health issue. Therefore, the goal of this study was to identify the prevalence and correlates of influencing early childbearing among teenage girls across Ethiopia.

Methods
We conducted a secondary analysis of cross-sectional data from the 2016 Ethiopian Demographic and Health Survey. A multistage stratified cluster sampling strategy based on the community was used to include the 3,498 participants in total. To determine the significantly correlated factors that influence adolescent pregnancy, a multilevel binary logistic regression analysis was used. The factors that have a significant association with early childbearing were identified using the Adjusted Odds Ratio (AOR) and 95% Confidence Interval (CI).

Results
This study demonstrated that 10.3% of teens across the country had children at an early age. The odds of early childbearing among teenage girls increased with first marriages occurring before the age of 18, non-formal education, being from a lower- or middle-class family, not using contraceptives, following Muslim or other religious beliefs, and being aware of the fertile window. Teenagers who had exposure to the media, however, had a reduced chance of becoming pregnant early.

Conclusions
The study indicates that early teenage childbearing is still Ethiopia’s most significant public health problem. Therefore, the Ethiopian government should ban early marriage while also taking steps to reduce the risk through formal education, improved access to reproductive health education, and contraception, particularly for adolescent girls from low-income families and, by educating religious institutions about pregnancy dangers.
HLA-B*53:01 Is a Significant Risk Factor of Liver Injury due to Phenytoin and Other Antiepileptic Drugs in African Americans
Authors: Nicoletti Paola , Dellinger Andrew , Li Yi-Ju , Barnhart Huiman , Phillips Elizabeth , Chalasani Naga ,   for the Drug Induced Liver Injury Network (DILIN) investigators
Published: August 2023

INTRODUCTION:
To investigate human leukocyte antigen alleles associated with liver injury due to antiepileptic drugs (AEDs) in African Americans (AA).

METHODS:
In this study, 21 AA with AED drug-induced liver injury (DILI), 176 AA with DILI due to non-AEDs, and 5816 AA population controls were included.

RESULTS:

HLA-B*53:01 was significantly associated with aromatic AED-DILI (odds ratio: 4.52, 95% confidence interval: 2.42–8.44, P = 1.46 × 10−5). Phenytoin DILI showed the strongest association with HLA-B*53:01 (odds ratio: 9.17; 95% confidence interval: 3.61–23.28, P = 1.1 × 10−5). The HLA-B*53:01 allele was carried by 8 of 9 AA phenytoin DILI cases.

DISCUSSION:

HLA-B*53:01 is a significant risk factor of liver injury due to antiepileptics, particularly phenytoin, in AA.
Hepatocellular carcinoma cell differentiation trajectory predicts immunotherapy, potential therapeutic drugs, and prognosis of patients
Authors: Qiu Jun , Wang Haoyun , Lv Xin , Mao Lipeng , Huang Junyan , Hao Tao , Li Junliang , Qi Shuo , Chen Guodong , Jiang Haiping 
Published: August 2023

Abstract
The aim of this study is to explore a novel classification and investigate the clinical significance of hepatocellular carcinoma (HCC) cells. We analyzed integrated single-cell RNA sequencing and bulk RNA-seq data obtained from HCC samples. Cell trajectory analysis divided HCC cells into three subgroups with different differentiation states: state 1 was closely related to phosphoric ester hydrolase activity, state 2 was involved in eukaryotic initiation factor 4E binding, translation regulator activity and ribosome, and state 3 was associated with oxidoreductase activity and metabolism. Three molecular classes based on HCC differentiation-related genes (HDRGs) from HCC samples were identified, which revealed immune checkpoint gene expression and overall survival (OS) of HCC patients. Moreover, a prognostic risk scoring (RS) model was generated based on eight HDRGs, and the results showed that the OS of the high-risk group was worse than that of the low-risk group. Further, potential therapeutic drugs were screened out based on eight prognostic RS-HDRGs. This study highlights the importance of HCC cell differentiation in immunotherapy, clinical prognosis, and potential molecular-targeted drugs for HCC patients, and proposes a direction for the development of individualized treatments for HCC.
Study on the cytokines related to SARS-Cov-2 in testicular cells and the interaction network between cells based on scRNA-seq data
Authors: Yu Fan , He Haihong , Huang Tingting , Zhou Yiwen 
Published: August 2023

Abstract
Inflammatory cytokine storms (CS) in COVID-19 patients are associated with elevated levels of 13 specific cytokines, potentially impacting male fertility by causing testicular cell damage and disrupting the immune microenvironment. Some patients present with scrotal discomfort and orchitis. However, few studies have explored cytokine expression in testicular cells and their role in cell-to-cell communication. In this study, we integrated single-cell sequencing data sets of testicular cells, annotating 20 cell clusters using marker genes and the Human Cell Landscape database. We constructed cell pseudo-chronological trajectories, hub genes, and analyzed the cytokine interaction network between sperm cells using CellChat. Our findings identified 12 types of testicular cells, with four cytokines (IL8, CCL2, CCL3, and TNF) potentially involved in immune processes. Pseudo-chronological trajectory analysis indicated IL8 and CCL3's essential roles in testicular macrophages and endothelial cell development, affecting the immune microenvironment. We determined eight key cytokines (IL1, IL2, IL4, IL6, CCL, CSF3, TNF, and IFN-II) functions in cell interaction networks. Network analysis of exogenous cytokines directly acting on testicular cells showed IL2 potentially affecting all testicular cells, suggesting a vital role in cell communication. This research offers valuable insights into CSs effects on testicular cells and their potential impact on male fertility during COVID-19 infection.
Stochastic gradient descent optimisation for convolutional neural network for medical image segmentation
Authors: Nagendram Sanam , Singh Arunendra , Harish Babu Gade , Joshi Rahul , Pande Sandeep Dwarkanath , Ahammad S. K. Hasane , Dhabliya Dharmesh , Bisht Aadarsh 
Published: August 2023

Abstract
In accordance with the inability of various hair artefacts subjected to dermoscopic medical images, undergoing illumination challenges that include chest-Xray featuring conditions of imaging acquisi-tion situations built with clinical segmentation. The study proposed a novel deep-convolutional neural network (CNN)-integrated methodology for applying medical image segmentation upon chest-Xray and dermoscopic clinical images. The study develops a novel technique of segmenting medical images merged with CNNs with an architectural comparison that incorporates neural networks of U-net and fully convolutional networks (FCN) schemas with loss functions associated with Jaccard distance and Binary-cross entropy under optimised stochastic gradient descent + Nesterov practices. Digital image over clinical approach significantly built the diagnosis and determination of the best treatment for a patient’s condition. Even though medical digital images are subjected to varied components clarified with the effect of noise, quality, disturbance, and precision depending on the enhanced version of images segmented with the optimised process. Ultimately, the threshold technique has been employed for the output reached under the pre- and post-processing stages to contrast the image technically being developed. The data source applied is well-known in PH2 Database for Melanoma lesion segmentation and chest X-ray images since it has variations in hair artefacts and illumination. Experiment outcomes outperform other U-net and FCN architectures of CNNs. The predictions produced from the model on test images were post-processed using the threshold technique to remove the blurry boundaries around the predicted lesions. Experimental results proved that the present model has better efficiency than the existing one, such as U-net and FCN, based on the image segmented in terms of sensitivity = 0.9913, accuracy = 0.9883, and dice coefficient = 0.0246.
Effects of physical exercise on biomarkers of oxidative stress in healthy subjects: A meta-analysis of randomized controlled trials
Authors: Wang Yahai , Luo Donglin , Jiang Haichao , Song Yu , Wang Zhiqiang , Shao Lin , Liu Yuxiao 
Published: August 2023

Abstract
This meta-analysis investigated the effect of physical exercise (PE) on the levels of oxidative biomarkers in randomized controlled trials (RCTs) involving healthy subjects. We searched five databases for articles until May 1, 2023. A random-effect meta-analysis, subgroup analysis, meta-regressions as well as trim and fill method were conducted using STATA 11.0, involving ten articles. According to the results of the meta-analysis, PE had no significant effect on superoxide dismutase (SOD), glutathione peroxidase, and catalase levels. PE induced significant increase in total antioxidant status (standardized mean difference [SMD] 1.53, 95% CI 0.73–2.32), and PE could significantly reduce the level of malondialdehyde (MDA) (SMD −1.11, 95% CI −2.15 to −0.06). Sensitivity analyses and subgroup analyses showed that male participants, body mass index (BMI) <25, exercise duration between 1 and 12 weeks, resistance exercise or multicomponent exercise, and exercise of low or moderate intensity were associated with a significant PE-induced decrease in MDA concentrations. Meta-regression analysis identified the age of the participants as a confounder of the effect of PE on SOD levels. The older age of the subjects was associated in a gradient fashion with incident SOD levels. Further RCTs are required to investigate the optimal PE protocol for people of different ages and BMI as well as the effect of PE on oxidative stress.
Coordination and referential dependencies: a dependency grammar account in terms of predicate-valent structures
Authors: Osborne Timothy , Li Jiaxin 
Published: August 2023

AbstractThe present paper explores the nexus of coordination and referential dependencies, focusing on sentences such as ‘Max and Lucie talked about him’, in which it is hardly possible forMaxandhimto be co-valued. Previous accounts claim that such referential dependencies are in fact possible on a collective reading. It will be demonstrated here, however, that informants consistently judge the co-valued reading in such cases to be either strongly marginal or unavailable, regardless of whether a collective or distributive reading obtains. It is claimed that the manner in which referential dependencies interact with coordinate structures can be addressed insightfully in terms of ‘predicate-valent’ structures (as opposed to ‘predicate-argument structures’). A constraint in this regard will be proposed: the ‘Conjunct Referential Dependency Constraint’ (CRDC). The CRDC is couched in a Dependency Grammar (DG) approach to syntax.
Promoting ELF awareness in Language Teacher Education and ELT practices: perspectives and challenges
Authors: Vettorel Paola , Antonello Monica 
Published: August 2023

Abstract
Research into the pedagogical implications of English as a Lingua Franca (ELF) has seen important developments over the last decade, through investigation of how English Language Teaching (ELT) can, and should, respond to the challenges and issues connected to the global spread of English in terms of curricula, syllabi, materials and classroom practices. In this perspective, Language Teacher Education is a central factor to promote awareness of the necessity to respond to how English is used as a global lingua franca today, not least in terms of Language Awareness, multilingual practices and meaning negotiation through Communication Strategies. In this paper we aim at addressing aspects related to teacher awareness as to ELF, in terms of how ‘language’, ‘language teaching and learning’ and ‘language use’ are conceived within an ELF-aware perspective. We will look in particular at the role that Language Awareness, Communicative Competence especially as to its strategic dimension in pragmatic moves, and multilingual practices play in ELF, and at their relevance in raising teachers’ awareness of ELF and ELF-aware pedagogic practices. We will then examine how these aspects interrelate with the three components in Sifakis’ ELF awareness model – awareness of language and language use, awareness of instructional practices, awareness of learning – also providing exemplifications of activities that could be used in ELF-oriented Teacher Education, and in ELT practices, to foster reflection on how they can become part of English language teaching and learning.
Examining ELF-aware teaching and learning: action research as a tool for ELF research and teacher education
Authors: Heike Christie 
Published: August 2023

Abstract
This paper examines the role that action research – including both academic studies and action research undertaken by teachers for the purposes of professional development – might play in helping to close the existing gap between the pedagogical implications of English as a Lingua Franca (ELF) research and the practical implementation of an ELF-oriented approach in the classroom. It is argued that the purposes and characteristic features of action research as a research methodology are particularly relevant and fitting to address the kinds of questions relating to pedagogy which remain at this stage of ELF research. To support this thesis, the heart of the paper presents findings from an applied linguistic study investigating the implementation of an ELF-oriented approach in a university-level pilot course in order to illustrate the kinds of insights which classroom-based action research studies can provide. Finally, the concluding section reflects on the role of action research as a part of teachers’ professional development, the potential contributions which such research might make to ELF research and the need for the wider ELF research community to pay more attention to findings from action research undertaken as part of teacher education programs.
Analysis of alternate material Onyx™ for total knee arthroplasty instrumentation sets
Authors: Gregg Nathan , Kendrick Alyssa M. , Carter Jill M. , Gittins Mark E. , MacNeill Sarah C. 
Published: August 2023

Abstract

Context
A 25-pound weight limit is currently set on containerized instrumentation sets by the Association of periOperative Registered Nurses (AORN) and the Association for the Advancement of Medical Instrumentation (AAMI), in order to reduce strain on the staff and ensure that the sets are not too crowded in order to preserve sterilization and drying of the instruments. This is pushing companies to reduce the weight and number of instrumentation sets for the operating room. One solution has been to explore the viability of new, lighter materials such as Onyx.

Objectives
The goal of this study is to evaluate the novel material Onyx as a viable material utilized in reusable total knee arthroplasty (TKA) instrumentation sets utilizing traditional steam sterilization as the sterilization method.

Methods
Mechanical and biocompatibility tests according to the American Society for Testing Materials (ASTM) and International Organization for Standardization (ISO) 10,993 were run to evaluate the Onyx Material to see if it would be a viable alternative to the stainless and martensitic steel that is currently being utilized.

Results
Gross warping and cracking after 10 rounds of sterilization was observed. This was qualitatively worse in the Onyx without a carbon fiber component. The Onyx material did not meet biocompatibility standards for its application.

Conclusions
Onyx was determined to not be a viable material for TKA instruments regarding multiple high-pressure and -temperature sterilizations and cytotoxic cell testing.
Crystal structure of 1-(4–chlorophenyl)-4-benzoyl-3-methyl-1H-pyrazol-5-ol, C17H13ClN2O2
Authors: Xu Li-Ying , Chen Chen-chen , Chen Meng-Qi , Chang Yue , Sang Rui-ge , Zhang Heng-Qiang 
Published: August 2023

Abstract
C17H13ClN2O2, monoclinic, P21/c (no. 14), a = 5.3601(4) Å, b = 10.6233(7) Å, c = 25.2125(16) Å, β = 92.920(5)°, V = 1433.96(17) Å3, Z = 4, R

gt
(F) = 0.0495, wR

ref
(F
2) = 0.1143, T = 173(10) K.
Infrared spectroscopy for ageing assessment of insulating oils via dielectric loss factor and interfacial tension
Authors: Qian Yi-Hua , Li Zhi , Zhao Yao-Hong , Wang Qing 
Published: August 2023

Abstract
Along with the increase in demand for electricity, dependability requirements for the power supply system also increase. Transformers are the backbone of the electrical system; thus, they must function reliably and safely. In this study, a method based on Fourier-transform infrared spectroscopy technology is proposed for assessing the ageing level of insulating oils. Copper-catalysed thermal ageing is applied to four distinct insulating oils at a temperature of

12

0

°

C

12{0}^{^\circ }{\rm{C}}

. The insulating oil ageing peaks are promptly measured using infrared spectroscopy, and the peak area ratios are associated with the interfacial tension and dielectric loss factor. It is observed that the peak area ratio of the ageing peaks and interfacial tension are significantly correlated, and this relationship can be used to determine the ageing condition of the insulating oil. The findings of this study can be used to design sensors for online monitoring of insulating oil quality.
Mars and Mercury. A golden wolf from Western Poland – a mysterious find
Authors: Kontny Bartosz , Miśta-Jakubowska Ewelina A. , Żabiński Grzegorz 
Published: August 2023

Abstract
The paper discusses a mysterious zoomorphic wolf-shaped copper alloy artefact that was discovered as a stray find in Międzyrzecz (Poland). The find is bar-like with a profiled engraved image of a lying animal, possibly a wolf. It is locally gilded on the visible side of “wolf” details. The gilding was made using an amalgam technique known since Antiquity, with the base metal composed of arsenical copper alloy with lead addition. A fixing element made of iron has only survived fragmentarily, which renders the reconstruction of the entire artefact’s shape impossible. Its function has not been identified, but a broad spectrum of possible interpretations has been proposed. Stylistic traits allow to date the artefact to the Migration Period, or more specifically to the 6th century. The wolf image implies that the artefact can be related to the Germanic warriors’ world. At present, it cannot be determined whether there was a 6th century settlement cluster in the vicinity of Międzyrzecz to which the find can be related, or we are dealing with an isolated testimony of population translocations.
Sox7‐positive endothelial progenitors establish coronary arteries and govern ventricular compaction
Authors: Chiang Ivy KN , Humphrey David , Mills Richard J , Kaltzis Peter , Pachauri Shikha , Graus Matthew , Saha Diptarka , Wu Zhijian , Young Paul , Sim Choon Boon , Davidson Tara , Hernandez‐Garcia Andres , Shaw Chad A , Renwick Alexander , Scott Daryl A , Porrello Enzo R , Wong Emily S , Hudson James E , Red‐Horse Kristy , del Monte‐Nieto Gonzalo , Francois Mathias 
Published: August 2023

AbstractThe cardiac endothelium influences ventricular chamber development by coordinating trabeculation and compaction. However, the endothelial‐specific molecular mechanisms mediating this coordination are not fully understood. Here, we identify the Sox7 transcription factor as a critical cue instructing cardiac endothelium identity during ventricular chamber development. Endothelial‐specific loss of Sox7 function in mice results in cardiac ventricular defects similar to non‐compaction cardiomyopathy, with a change in the proportions of trabecular and compact cardiomyocytes in the mutant hearts. This phenotype is paralleled by abnormal coronary artery formation. Loss of Sox7 function disrupts the transcriptional regulation of the Notch pathway and connexins 37 and 40, which govern coronary arterial specification. Upon Sox7 endothelial‐specific deletion, single‐nuclei transcriptomics analysis identifies the depletion of a subset of Sox9/Gpc3‐positive endocardial progenitor cells and an increase in erythro‐myeloid cell lineages. Fate mapping analysis reveals that a subset of Sox7‐null endothelial cells transdifferentiate into hematopoietic but not cardiomyocyte lineages. Our findings determine that Sox7 maintains cardiac endothelial cell identity, which is crucial to the cellular cross‐talk that drives ventricular compaction and coronary artery development.