bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Comparisons of Lavender and Jasmine Aromatherapy Effectiveness on Depression Level for Medical Students
Authors: Sukarman Tania Lysandra , Gani Irna Permanasari , Jasaputra Diana Krisanti 
Published: January 2023

Background Everyone can suffer from depression, including teenagers. Students in the medical faculty show higher depression levels than other faculties students due to being unable to adapt to the new daily activity as medical students. Lavender and Jasmine aromatherapy can reduce depression levels because it contains linalool.Objective The purpose of this research is to compare the effectiveness between Lavender and Jasmine aromatherapy on Maranatha Christian University medical student depression levels.Method This analytical research design used a simple random sampling method on 45 subjects divided into 3 groups: Lavender, Jasmine, and Control. The data measured was the total score of the BDI II (Beck Depression Inventory II) questionnaire before and after being given treatment for 1 week.Results The average BDI II score in the Lavender and Jasmineâ€™s groups decrease from 19.73 (moderate depression) to 14.73 (mild depression) in the Lavenderâ€™s group and 19,33 (moderate depression) to 14.06 (mild depression) in Jasmineâ€™s. Thereâ€™s also decreased score in Control group, from 20.60 to 18.86 (mild depression).Â Furthermore, data is converted into BDI IIâ€™s scores decrease percentage, 24.00% for Lavenderâ€™s group, 28.85% for Jasmineâ€™s, and 5.80% for Controlâ€™s. Data were tested by the Kruskal Wallis test with significant results p=0.001 (p<0.05) followed by Mann-Whitney test.Conclusion Resume of this research is both Lavender and Jasmine aromatherapy has equal potential for reducing depression levels.Conclusion Resume of this research is both Lavender and Jasmine aromatherapy has equal potential for reducing depression levels.
Curcumin Combats against Gastrointestinal Cancer: A Review of
Current Knowledge Regarding Epigenetics Mechanisms with a
Focus on DNA Methylation
Authors: Jafari-Nozad Amir Masoud , Jafari Amirsajad , Zangooie Alireza , Behdadfard Mohammad , Zangouei Amir Sadra , Aschner Michael , Farkhondeh Tahereh , Samarghandian Saeed 
Published: January 2023

Abstract:
Gastrointestinal (GI) cancers are one of the most common human malignancies
and a leading cause of morbidity and mortality worldwide. One of the most prominent
hallmarks of cancer and a basic trait of almost all GI malignancies is genomic/epigenomics
alterations. DNA methylation is highlighted as a fundamental mechanism underlying
the inactivation of several tumor-suppressor gene signaling pathways. Thus, sites
of DNA methylation can be triggered for cancer therapy. Available therapeutic procedures
for GI cancer show unsatisfactory efficacy, and some treatments are associated
with severe side effects, including ulceration or bleeding. Therefore, it is essential to find
alternative treatments. There is growing evidence indicating that some chemopreventive
phytochemicals can combat cancer. One of the most systematically investigated nutraceuticals
for its advantages in managing different diseases is curcumin (CUR). CUR is well
known for its potent anticancer characteristics by targeting epigenetic mechanisms, with
DNA methylation at the forefront. Prior investigations have indicated that CUR treatment
can benefit GI cancers by controlling several signaling pathways related to oxidative
stress and epigenomics pathways. The present literature displays recent evidence regarding
DNA methylation alterations by CUR and its potential role in GI cancer prevention
and treatment.
Intracellular Ellagic Acid Derived from Goat Urine DMSO Fraction
(GUDF) Predicted as an Inhibitor of c-Raf Kinase
Authors: Raj Ajay Kumar , Lokhande Kiran Bharat , Prasad Tanay Kondapally , Nandangiri Rasika , Choudhary Sumitra , Pal Jayanta Kumar , Sharma Nilesh Kumar 
Published: January 2023

Background:
Dietary chemicals and their gut-metabolized products are
explored for their anti-proliferative and pro-cell death effects. Dietary and metabolized
chemicals are different from ruminants such as goats over humans.

Methods:
Loss of cell viability and induction of death due to goat urine DMSO fraction
(GUDF) derived chemicals were assessed by routine in vitro assays upon MCF-7
breast cancer cells. Intracellular metabolite profiling of MCF-7 cells treated with goat
urine DMSO fraction (GUDF) was performed using an in-house designed vertical tube
gel electrophoresis (VTGE) assisted methodology, followed by LC-HRMS. Next, identified
intracellular dietary chemicals such as ellagic acid were evaluated for their
inhibitory effects against transducers of the c-Raf signaling pathway employing
molecular docking and molecular dynamics (MD) simulation.

Results:
GUDF treatment upon MCF-7 cells displayed significant loss of cell viability
and induction of cell death. A set of dietary and metabolized chemicals in the intracellular
compartment of MCF-7 cells, such as ellagic acid, 2-hydroxymyristic acid, artelinic
acid, 10-amino-decanoic acid, nervonic acid, 2,4-dimethyl-2-eicosenoic acid, 2,3,4'-
Trihydroxy,4-Methoxybenzophenone and 9-amino-nonanoic acid were identified.
Among intracellular dietary chemicals, ellagic acid displayed a strong inhibitory affinity
(-8.7 kcal/mol) against c-Raf kinase. The inhibitory potential of ellagic acid was found
to be significantly comparable with a known c-Raf kinase inhibitor sorafenib with overlapping
inhibitory site residues (ARG450, GLU425, TRP423, VA403).

Conclusion:
Intracellular dietary-derived chemicals such as ellagic acid are suggested
for the induction of cell death in MCF-7 cells. Ellagic acid is predicted as an inhibitor
of c-Raf kinase and could be explored as an anti-cancer drug.
Design, Synthesis, and Biological Evaluation of a Class of TEMPOmodified Naphthalimide Derivatives with Good Selectivity for Tumor Cells
Authors: Hao Qingqing , Zhang Yujiao , Jiang Xuliang 
Published: January 2023

Background:
Naphthalimides have been receiving continuous attention for their outstanding
performance in treating cancer. However, as a class of cytotoxic anti-tumor agents, their toxic side effects
greatly limit their clinical application. Therefore, developing naphthalimide reagents with good selectivity
for tumor cells is of great importance.

Methods:
A class of TEMPO-modified naphthalimide derivatives substituted with oxygen at the 6-
position were designed, synthesized, and evaluated for the anti-tumor activity in vitro against three cancer
cell lines (A549, MCF-7, and HeLa) as well as one normal human liver cell line (QSG-7701) by MTT
assay. HRMS (or MS) and EPR spectra were used to identify the structures of target compounds. The
UV–vis titration absorption spectra were performed to study the interaction between compounds and
DNA.

Results:
The target compounds NT3, NT9, NT10, NT11, and NT12 exhibited moderate inhibition to all
the three tested tumor cell lines, while NT1, NT2, and NT4 showed selectivity against A549, All the target
compounds did not show measurable activities in QSG-7701, which imply the target compounds are
likely to overcome the nonspecific toxicity against normal cells. UV-vis spectra showed this class of
compounds could effectively intercalate into DNA and selectively bind to G-C base pairs.

Conclusion:
A novel class of TEMPO-modified naphthalimide derivatives substituted with oxygen at 6-
position and the preliminary discussion on their SARs provide promising opportunities to guide further
research on naphthalimide derivatives as anti-tumor agents.
IN VITRO EVALUATION OF ANTHELMINTIC ACTIVITY OF AQUEOUS EXTRACT OF ARDISIA COLORATA ROXB. LEAVES IN ADULT EARTHWORMS
Authors: SARKAR PRASENJIT , DEVI N. MEENA , MEETEI U. DHARMARAJ , V. GOBINATH 
Published: January 2023

Objective: The study aims to evaluate the anthelmintic activity of aqueous extract of Ardisia colorata Roxb. leaves (AQEAC) using adult earthworms (Pheretima posthuman).
Methods: The total of 24 adult earthworms were divided into four groups, with six worms in each group (n=6). The anthelmintic activity of AQEAC at two different doses (25 mg/ml and 50 mg/ml) was evaluated by assessing the time of paralysis (min) and time of death (min) of the earthworms. Albendazole (25 mg/ml) was used as standard and 2% gum acacia as control.
Results: The result showed that AQEAChad significant anthelmintic activity (p<0.001) in a dose-dependent manner but was less potent than the standard drug albendazole.
Conclusion: AQEAC demonstrated significant anthelmintic activity but was less potent than the standard drug albendazole. However, further studies with higher doses are required to evaluate the dose-dependent activity and to evaluate the exact mechanism responsible for anthelmintic activity.
SYNTHESIS AND ANTIMICROBIAL SCREENING OF 2,6-DIAMINOPYRIDINE SCHIFF BASES OF ISATIN DERIVATIVES
Authors: SHRIVASTAVA SHOBHIT , AHUJA DHARMENDRA 
Published: January 2023

Objective: Synthesis and in vitro antimicrobial screening of 2,6-diaminopyridine Schiff bases of isatin derivatives.
Methods: Isatin and it’s 5-substituted derivatives (S1-5) were prepared by Sandmeyer method and N2-Benzylidenepyridine-2,6-Diamine (M) was obtained by the reacting 2,6-diaminopyridine with benzaldehyde. Schiff bases (MS1-5) were prepared by reacting isatin derivatives (S1-5) with N2-Benzylidenepyridine-2,6-Diamine (M). Resultant compound structures were confirmed by some analytical techniques’ data. All synthesized compound were screened for in vitro antimicrobial activity by broth dilution methods against Staphylococcus aureus (MTCC-3160), Bacillus subtilus (MTCC-441), Escherichia coli (MTCC-452), Klebsiella pneumoniae (MTCC-432), Candida albicans (MTCC-183), Aspergillus flavus (MTCC-277) using ciprofloxacin and fluconazole as standard drugs.
Results: All compounds exhibited better antibacterial activity compared to standard. Among all compounds, MS2 and MS4 were found most effective against all strains of bacteria. Only MS3 and MS5 showed antifungal activity against both fungal strains.
Conclusion: All newly synthesized Schiff bases of isatin showed significant antibacterial activity against the tested strain of bacteria, only a few compounds were found effective as antifungal.
POINT PREVALENCE OF PAEDIATRIC DENGUE VIRAL INFECTION
Authors: SUCHITRA PUSAPATI , SRV AMARTHYA , PADMAJA I. JYOTHI , VIJAYALAKSHMI PAYALA 
Published: January 2023

Objective: The study's objective is to evaluate the prevalence of dengue in the paediatric age group based on demographic data and clinical symptoms.
Methods: The study was conducted in the Department of Paediatrics and Central Research Laboratory in a Tertiary Care Hospital in Visakhapatnam. Six months of data were collected from Jan 2022 to June 2022 and a maximum of 100 OPD/IPD cases have been registered during this study period. The entire medical history of all dengue cases, including signs and symptoms, method of diagnosis, management, length of stay, and clinical outcomes, were collected from patient information. NS1 antigen detection was performed by rapid test and Dengue ELISA was performed as a confirmatory test for the detection of IgG and IgM antibodies.
Results: Among the 100 suspected cases of dengue reported to OPD/IPD, 83(83%) were confirmed as dengue positive, and 17(17%) were found to be non-dengue cases with ELISA. More cases were noticed in female children 52 (55%). Prevalence was more in the age group of 5-11 y 43 (52%). The majority number of cases were reported with fever 82 (98.8%) followed by symptoms like vomiting 41(49%), cold 19(16%), and cough 18(15%).
Conclusion: Understanding dengue fever in children, including clinical symptoms, etiology, diagnostic testing, therapy, and prevention, is critical for lowering disease fatality rates.
PSORIASIFORM DRUG ERUPTION INDUCED BY ANTI-TUBERCULOSIS MEDICATION: A CASE REPORT
Authors: SINDHU NITIKA 
Published: January 2023

Objective: Psoriasiform drug eruptions can be induced by several drugs. Psoriasis is a chronic inflammatory disease characterized by T-cell-mediated cytokine production that drives the hyperproliferation and abnormal differentiation of keratinocytes. Drugs can cause new lesions when there is no prior history or family history of psoriasis. Based on the psoriatic drug eruption probability score, β‐blockers, synthetic anti‐malarial drugs, non‐steroidal anti‐inflammatory drugs (NSAIDs), lithium, digoxin and tetracycline antibiotics are relevant in psoriasis.
Methods: A 58-year-old male was admitted to the Department of Respiratory Medicine at B. P. S G. M. C, Khanpur Kalan, Sonepat as a case of pulmonary tuberculosis and was put on anti-tubercular drugs CAT-I (according to RNTCP guidelines). The patient had a history of diabetes mellitus and hypertension for the past six years. On the third day of initiation of ATT, the patient started developing a psoriasiform rash. The psoriasiform rash began to improve within a few days after discontinuing the ATT. A causality assessment was done as per the WHO-UMC scale, which showed that the adverse events were likely caused due to the ATT.
Results: Psoriasiform rash is a severe adverse drug reaction characterized by widespread lesions. Among all the various adverse drug reactions, lichenoid drug eruption is commonly associated with anti-tuberculosis medication and needs to be differentiated from psoriasiform eruption. The underlying pathomechanism of drug-induced psoriasiform eruptions remains uncertain, although several immunological interactions have been hypothesized.
Conclusion: ATT has been reported to cause psoriasiform rash, and its drug component needs to be reconsidered in view of safer alternatives available.
PRESCRIPTION PATTERN OF ANTIBIOTICS AND THEIR APPROPRIATENESS IN PATIENTS WITH CHRONIC KIDNEY DISEASE-AN OBSERVATIONAL STUDY IN A TERTIARY CARE TEACHING HOSPITAL IN SOUTH INDIA
Authors: CHALIVENDRA PALLAVI , K. UMAMAHESWARA RAO , SUCHARITHA J , CHANDRA VURIMI BHOPAL , NELAVALA ANJANI DEVI 
Published: January 2023

Objective: The primary objective of the study was to assess the prescribing pattern of antimicrobial agents in patients with chronic kidney disease. The secondary objectives of this study are to assess antibiotic appropriateness and dose optimization in patients with chronic kidney disease in relation to their comorbidities.
Methods: A retrospective study was conducted, and medical records of all patients with CKD who were admitted in the nephrology department of Sri Venkateswara Institute of Medical Sciences, Tirupati, during Jan 2018-Dec 2018 were reviewed for antibiotic prescriptions. A total of 200 medical records were selected and assessed for antimicrobial prescriptions. A p-value <0.05 was considered significant throughout the statistical analysis.
Results: Analysis showed that overall 163 drugs were prescribed to CKD patients, of which nearly 96 (58.9%) required dosage adjustment. Of those 163 drugs, the majority N= 25 (26%), were unadjusted, and the remaining N = 71 (74%) were properly adjusted. The length of hospitalization of CKD patients was below 7 was 13.5%, above 7 was 86.5%. Mean and SD was 10.27±7.18 d, (Range: 1–35 d). The Chi-square analysis confirmed that out of the seven studied variables, two i.e. Length of stay days; p<0.001.
Conclusion: It is concluded that the occurrence of medication dosing errors was moderate in hospitalized chronic kidney disease patients in our study. Nearly 20% of patients who had prolonged stays were prescribed antibiotics for a prolonged period. The predictors of medication dosing errors in CKD patients were the severe-to-end stages of chronic kidney disease, the number of prescribed antibiotics, and the length of hospitalization.
Pengaruh motivasi dan pelatihan kerja terhadap kinerja karyawan pada era new normal
Authors: Arta I Ketut Yoga Arshana , Lestari Denok , Susanti Luh Eka 
Published: January 2023

Penelitian ini bertujuan untuk mengetahui pengaruh motivasi dan pelatihan kerja terhadap kinerja karyawan di hotel Bali Tropic Resort & SPA pada era new normal secara simultan dan parsial. Penelitian ini menggunakan metode kuantitatif dengan pengolahan data primer melalui kuesioner yang diberikan kepada karyawan di hotel Bali Tropic Resort & SPA. Teknik pengambilan sampel menggunakan simple random sampling. Sampel yang digunakan adalah 57 responden dari 160 karyawan di hotel Bali Tropic Resort & SPA. Analisis data yang digunakan yaitu uji asumsi klasik dan regresi linier berganda. Hasil penelitian menunjukan bahwa secara simultan motivasi dan pelatihan kerja berpengaruh positif dan signifikan terhadap kinerja karyawan, dimana hasil nilai uji F didapatkan dengan Fhitung = 34,457 dan nilai signifikan 0,000 < 0,05. Secara parsial motivasi berpengaruh positif dan signifikan (0,003 < 0,05) terhadap kinerja karyawan dengan t hitung = 3.091, pelatihan kerja berpengaruh positif dan signifikan (0,000 < 0,05) terhadap kinerja karyawan dengan t hitung = 4.445.

This study aims to determine the effect of motivation and job training on employee performance at the Bali Tropic Resort & SPA hotel in the new normal era simultaneously and partially. This study uses quantitative methods with primary data processing through questionnaires given to employees at the Bali Tropic Resort & SPA hotel. The sampling technique used is simple random sampling. The sample used was 57 respondents from 160 employees at the Bali Tropic Resort & SPA hotel. The data analysis used is the classical assumption test and multiple linear regression. The results showed that simultaneously motivation and job training had a positive and significant effect on employee performance, where the results of the F test value were obtained with Fcount = 34,457 and a significant value of 0.000 <0.05. Partially, motivation has a positive and significant effect (0.003 < 0.05) on employee performance with t count = 3.091, job training has a positive and significant effect (0.000 < 0.05) on employee performance with t count = 4.445.
Pemodelan Ekonometrika Spasial Persentase Penduduk Miskin di Provinsi Papua
Authors: Musa M , Fauziyah M 
Published: January 2023

Kemiskinan merupakan salah satu permasalahan yang terjadi di Indonesia. Pada tahun 2020 persentase penduduk miskin di Indonesia sebesar 9,78%, dengan persentase tertinggi berada di Provinsi Papua yaitu sebesar 911,37 ribu orang (26,64%). Hal ini menunjukkan perlunya dilakukan suatu penelitian untuk mengetahui faktor-faktor yang berpengaruh terhadap persentase penduduk miskin di Provinsi Papua. Penelitian ini menggunakan pemodelan ekonometrika spasial dengan pendekatan Spatial Autoregressive Model (SAR) dan Spatial Durbin Model (SDM). Kedua model tersebut digunakan karena hasil uji dependensi spasial menunjukkan bahwa terjadi dependensi spasial antar lokasi yang berdekatan pada variabel dependen dan beberapa variabel independen. Diperoleh hasil penelitian dengan menggunakan model regresi klasik (AIC sebesar 189,5021), SAR (AIC sebesar 188,3680), dan SDM (AIC sebesar 190,8151). Model yang paling baik digunakan berdasarkan kriteria AIC terkecil adalah SAR, dengan variabel yang berpengaruh signifikan terhadap persentase penduduk miskin di Provinsi Papua, yaitu variabel PDRB per kapita (X1), rata-rata lama sekolah (X3) dan alokasi dana desa (X5).
Kata kunci : Ekonometrika, Kemiskinan, Spatial Autoregressive Model, Spatial Durbin Model.
”Både borgere og bønder og dog ingen af delene”. Småbyfeudalisme i enevældens nordjyske godsejerbyer
Authors: Mührmann-Lund Jørgen 
Published: January 2023

“Both burghers and peasants and yet none of them.” Small-town feudalism in manorial towns in North Jutland
Unlike the rest of Scandinavia, few new towns were founded in Denmark in the period from 1500 to 1850. In North Jutland, however, some small towns were founded to trade with the new towns that were established in southern Norway in the 17th and 18th centuries. This chapter examines the Norwegian historian Finn-Einar Eliassen’s theory that the new towns in North Jutland resembled those in southern Norway in the sense that they also lay on private lands and were dominated by private landowners. After the Reformation in 1536, the king seized control of the towns of Thisted and Sæby, which had previously been owned by the church. In Limfjord, the growing fishing port of Nibe lay on royal land. The town had its own court, and the inhabitants did not pay feudal dues. However, when the town land was sold to a manorial lord in 1664, they were obliged to pay feudal dues. Nibe kept its own court and received town privileges in 1727. Løgstør was also a growing fishing port with its own court, situated on royal land. Unlike Nibe, Løgstør’s inhabitants bought their own dues after the town was sold to a manorial lord in 1671, but the town was not granted town privileges like Nibe. Struer grew as a trading port on the land of a manorial lord but was bought by a company of nine burghers from Holstebro in 1799. On the east coast of North Jutland, the crown established garrisons at Hals and Fladstrand after defeats in the Swedish Wars. Hals received town privileges in 1656, but never grew to be a town, whereas Fladstrand grew to be a town on the land of a manorial lord. In 1719, its inhabitants got into a conflict with their lord when they petitioned the king to become burghers free of feudal dues. Instead, the land with its dues was bought by a local merchant in 1749 and by the town government after Fladstrand received town privileges under the new name of Frederikshavn in 1818. On the north-western coast of Jutland, the ports of Klitmøller and Løkken grew as a result of trade with Norway. The ports were dominated by rich peasant merchants that had, despite their status as tenants, the economic power to dominate the manorial lords and the towns of Thisted and Hjørring. The ferry town of Nørresundby grew as a satellite town around the ferry crossing to Aalborg. The inhabitants violated the privileges of Aalborg, but were protected by the lords of this town. In sum, the power relations of the private towns in North Jutland resembled those of their Norwegian counterparts. The private owners had the right to demand feudal dues, but they did not exert power over the courts or the regulation of the towns as in Norway.