bluuebunny/crossref_metadata_2025_split huggingface dataset:
School nursing: New ways of working with children and young people during the Covid‐19 pandemic: A scoping review
Authors: Cook Georgia , Appleton Jane V. , Bekaert Sarah , Harrold Tikki , Taylor Julie , Sammut Dana 
Published: December 2022

AbstractAimTo examine how school nurse practice evolved as a result of the Covid‐19 pandemic.DesignA scoping review of international literature, conducted and reported in line with Arksey and O'Malley's (2005) framework.Data SourcesSearches were conducted in September 2021. Ten databases were searched: The British Nursing Database, CINAHL, Cochrane Library, Consumer Health Database, Health and Medicine, Nursing and Allied Health, Public Health, PsycINFO, PubMed and Web of Science. Relevant grey literature was identified through hand searching.Review MethodsA minimum of three reviewers independently screened articles and two reviewers independently undertook data extraction, with any decisions made collaboratively with the wider team. Much of the literature was not empirical work and so it was not possible to apply a traditional quality appraisal framework.ResultsSearches identified 554 papers (after deduplication) which were screened against title and abstract. Following the full‐text review, 38 articles underwent data extraction and analysis. The review findings highlighted that school nurses adapted their practice to ensure they were able to continue providing their formal and informal school health offer to children, young people and their families and continued working closely with the multidisciplinary team. In addition, the expanded public health role generated by Covid‐19 for school nurses' work was considerable, multi‐layered and added to their routine workload. School nurses displayed resilience, adaptability and creativity in their response to delivering services during Covid‐19.ConclusionSchool nurses took on a leading public health role during the Covid‐19 pandemic. Some developments and practices were highlighted as beneficial to continue beyond the pandemic. However, formal evaluation is needed to identify which practices may merit integration into routine practice. Continued investment in staff and infrastructure will be essential to ensuring school nurses continue to expand their practice and influence as public health experts.
Evaluating California nursing homes' emergency preparedness for wildfire exposure
Authors: Festa Natalia , Heaphy Nora M. , Throgmorton Kaitlin Fender , Canavan Maureen , Gill Thomas M. 
Published: December 2022

AbstractBackgroundThe relationship between the risk of exposure to environmental hazards and the emergency preparedness of nursing homes is not well‐understood. This study evaluates the association between wildfire exposure risk and nursing home emergency preparedness.MethodsFrom a sample of Centers for Medicare & Medicaid Services (CMS) certified nursing homes in California, we determined the prevalence of “exposed” facilities that were located within 5 km of a wildfire risk area, as informed by a field‐tested model. Among the 1182 nursing homes, we identified emergency preparedness deficiencies from January 2017 to December 2019. We estimated associations between exposure and emergency preparedness deficiencies using unadjusted and adjusted generalized estimating equations with logistic and negative binomial distributions.ResultsA greater percentage of the 495 exposed facilities had at least one emergency preparedness deficiency than the 687 unexposed facilities (83.9% vs 76.9%). The mean (3.6 vs 3.2) and median (3 vs 2) numbers of emergency preparedness deficiencies were also greater for exposed facilities. In both the unadjusted and adjusted analyses, exposure to wildfire risk was significantly associated with the likelihood of at least one emergency preparedness deficiency (adjusted odds ratio 1.52, p‐value 0.007). There was a positive but not statistically significant association between exposure and the number of emergency preparedness deficiencies assigned to a nursing home (adjusted rate ratio 1.12, p‐value 0.062). These results were consistent in analyses that used more stringent distance‐ and severity‐thresholds to define exposure status.ConclusionCalifornia nursing homes at heightened risk of exposure to wildfires have poorer emergency preparedness than unexposed facilities. These findings suggest that nursing home management and staff may be unaware of important environmental risks to which their facilities are exposed. Improved integration of nursing homes into community disaster planning may better align facility preparedness with surrounding wildfire risk.
Overcoming the challenges of preserving lipid‐richCannabis sativaL. glandular trichomes for transmission electron microscopy
Authors: Livingston Samuel J. , Chou Eva Yi , Quilichini Teagen D. , Page Jonathan E. , Samuels A. Lacey 
Published: December 2022

AbstractCannabis glandular trichomes produce and store an abundance of lipidic specialised metabolites (e.g. cannabinoids and terpenes) that are consumed by humans for medicinal and recreational purposes. Due to a lack of genetic resources and inherent autofluorescence of cannabis glandular trichomes, our knowledge of cannabinoid trafficking and secretion is limited to transmission electron microscopy (TEM). Advances in cryofixation methods has resulted in ultrastructural observations closer to the ‘natural state’ of the living cell, and recent reports of cryofixed cannabis trichome ultrastructure challenge the long‐standing model of cannabinoid trafficking proposed by ultrastructural reports using chemically fixed samples. Here, we compare the ultrastructural morphology of cannabis glandular trichomes preserved using conventional chemical fixation and ultrarapid cryofixation. We show that chemical fixation results in amorphous metabolite inclusions surrounding the organelles of glandular trichomes that were not present in cryofixed samples. Vacuolar morphology in cryofixed samples exhibited homogenous electron density, while chemically fixed samples contained a flocculent electron dense periphery and electron lucent lumen. In contrast to the apparent advantages of cryopreservation, fine details of cell wall fibre orientation could be observed in chemically fixed glandular trichomes that were not seen in cryofixed samples. Our data suggest that chemical fixation results in intracellular artefacts that impact the interpretation of lipid production and trafficking, while enabling greater detail of extracellular polysaccharide organisation.
Medicinal cannabis improves sleep in adults with insomnia: a randomised double‐blind placebo‐controlled crossover study
Authors: Ried Karin , Tamanna Tasnuva , Matthews Sonja , Sali Avni 
Published: December 2022

SummaryInsomnia or difficulty falling and or staying asleep is experienced by up to 30% of the general population. This randomised crossover double‐blind placebo‐controlled 6‐week trial aimed to assess the tolerability and effectiveness of the Entoura‐10:15 medicinal cannabis oil on sleep in adults with insomnia. A total of 29 participants with self‐reported clinical insomnia completed the crossover trial. Participants were randomly allocated to receive placebo or active oil containing 10 mg/ml tetrahydrocannabinol (THC) and 15 mg/ml cannabidiol (CBD) over 2‐weeks titrated 0.2–1.5 ml/day, followed by a 1‐week wash‐out period before crossover. Tolerability was assessed by daily diary. Effectiveness was measured by saliva midnight melatonin levels, validated questionnaires, i.e., the Insomnia Severity Index, and the Fitbit activity/sleep wrist tracker. Entoura‐10:15 medicinal cannabis oil was generally well tolerated, and was effective in improving sleep, whereby 60% of participants no longer classified as clinical insomniacs at the end of the 2‐week intervention period. Midnight melatonin levels significantly improved in the active group by 30% compared to a 20% decline in the placebo group (p = 0.035). Medicinal cannabis oil improved both time and quality of sleep, in particular light sleep increased by 21 min/night compared to placebo (p = 0.041). The quality of sleep improved overall by up to 80% in the active group (pPhase2 = 0.003), including higher daily functioning (p = 0.032). Observed effects were more pronounced in Phase 2 due to the period effect and loss of blinding. Entoura‐10:15 medicinal cannabis oil was well tolerated and effective in improving sleep in adults with insomnia.
Evaluation of metagenomic next‐generation sequencing diagnosis for invasive pulmonary aspergillosis in immunocompromised and immunocompetent patients
Authors: Zhan Wenyu , Liu Qingjun , Yang Changqing , Zhao Zhan , Yang Lei , Wang Yubao , Feng Jing 
Published: December 2022

AbstractBackgroundInvasive pulmonary aspergillosis (IPA) can occur in both immunocompromised and non‐immunocompromised hosts, and early diagnosis of IPA is difficult. Metagenomic next‐generation sequencing (mNGS) is a novel non‐migratory pathogen detection method; however, utilising this method for IPA diagnosis is challenging due to the current lack of a unified clinical interpretation standard following Aspergillus detection using mNGS.ObjectivesTo investigate the accuracy of IPA diagnosis by positive bronchoalveolar lavage fluid (BALF) mNGS results in immunocompromised and immunocompetent patients.MethodsWe retrospectively included patients with confirmed pulmonary infections having a BALF mNGS result of Aspergillus reads ≥1. We compared the accuracy of using mNGS for IPA diagnosis in patients with different immune statuses based on the revised EORTC/MSG criteria.ResultsOverall, 62 mNGS Aspergillus‐positive patients were divided into two groups: with (41) and without IPA (21). In univariate logistic regression analysis, immunocompromised function, fever, halo sign on CT image, and multiple masses or nodules were associated with mNGS Aspergillus‐positive IPA diagnosis. In multivariate logistic regression analysis, immunocompromised function (OR = 6.68, 95% CI: 1.73–25.87, p = .006) and a halo sign (OR = 7.993, 95% CI: 2.07–30.40, p = .003) were independent risk factors. The concordance rate of IPA diagnosis was significantly higher in immunocompromised patients [82.1% (23/28)] than in non‐immunocompromised patients [52.9% (18/34); p = .016].ConclusionsFor immunocompromised patients, a combination of mNGS testing and lung CT imaging can be used for IPA diagnosis. However, caution is required in IPA diagnosis based on positive mNGS results in non‐immunocompromised patients.
Patients' perspectives of recovery after COVID‐19 critical illness: An interview study
Authors: Bench Suzanne , Cherry Helen , Hodson Matthew , James Alison , McGuinness Nicola , Parker Gaby , Thomas Nicola 
Published: December 2022

AbstractBackgroundCritical illness is a traumatic experience, often resulting in post‐intensive care syndrome, affecting people's physical, psychological, emotional, and social well‐being. The early recovery period is associated with increased risk, negatively impacting longer‐term outcomes.AimsThe aims of this study were to understand the recovery and rehabilitation needs of people who survive a COVID‐19 critical illness.Study designAn exploratory descriptive qualitative interview study with 20 survivors of COVID‐19 critical illness from two community‐based healthcare settings in London, England. Data collection took place September 2020–April 2021, at least 1 month after hospital discharge by telephone or virtual platform. Data were subjected to inductive thematic analysis and mapped deductively to the three core concepts of self‐determination theory: autonomy, competence and relatedness.ResultsThree key themes emerged: traumatic experience, human connection and navigating a complex system. Participants described how societal restrictions, fear and communication problems caused by the pandemic added to their trauma and the challenge of recovery. The importance of positive human connections, timely information and support to navigate the system was emphasized.ConclusionsWhilst findings to some extent mirror those of other qualitative pre‐pandemic studies, our findings highlight how the uncertainty and instability caused by the pandemic add to the challenge of recovery affecting all core concepts of self‐determination (autonomy, competence, relatedness).Relevance to clinical practiceUnderstanding survivors' perspectives of rehabilitation needs following COVID‐19 critical illness is vital to delivery of safe, high‐quality care. To optimize chances of effective recovery, survivors desire a specialist, co‐ordinated and personalized recovery pathway, which reflects humanized care. This should be considered when planning future service provisions.
How are different math knowledge presentations associated with math anxiety?
Authors: Li Tian , Chen Chuansheng , Zhou Xinlin 
Published: December 2022

AbstractA close relationship between math performance and math anxiety has been demonstrated, but how different presentations of mathematics are associated with math anxiety has not been investigated. This study recruited 826 elementary school students in grades 5 and 6. All students were given math trait and state anxiety questionnaires; a nonverbal matrix reasoning task; and verbalized, symbolic, and situational fraction problem‐solving tasks. After data cleaning, 475 boys and 323 girls (798 in total) were included in the analysis (mean age = 11.79, SD = 0.82). Partial correlation analysis showed that students’ math traits and state anxiety were more closely related to symbolic fraction problem‐solving than to verbalized and situational fraction problem‐solving. Mixed linear model analysis showed that math state anxiety for symbolic problem‐solving was significantly greater than that for verbalized and situational problem‐solving. Based on these findings, we concluded that the presentation of symbolic math is more likely to induce math anxiety than verbalized or situational math. This finding has potential practical applications in math anxiety interventions and education.
Delayed depolarization and histologic abnormalities underlie the Brugada syndrome
Authors: Martini Bortolo , Martini Nicolò , De Mattia Luca , Buja Gianfranco 
Published: December 2022

AbstractBrugada syndrome (BrS) is a controversial disease whose pathophysiology is still far from being fully understood. Unlike other cardiological disorders, a definite etiology has not yet been established so that it could be summarized under two main chapters: “functional” or “organic”, “repolarization” or “depolarization” disorder. Despite initial descriptions leaned towards the organic substrate and delayed depolarization features, functional and repolarization theories have attracted most of the Cardiological attention for many years. Data from electrocardiography, endocavitary tracings, electroanatomic mapping and histopathology, however, demonstrated that BrS is mainly characterized by structural myocardial changes mostly at the right ventricular outflow tract (RVOT), but also at the right ventricle (RV) and by delayed conduction at the same sites. Conduction disorders at different levels may also be present and identify patients at high risk for major arrhythmic events. The aim of the present review is to provide the current state of art of the pathophysiology of BrS, focusing on electro‐vectorcardiography and electrophysiological features, histopathology, echocardiography, and cardiac magnetic resonance imaging (CMRI).
A 14‐3‐3 protein positively regulates rice salt tolerance by stabilizing phospholipase C1
Authors: Wang Ningna , Shi Yiyuan , Jiang Qun , Li Huan , Fan Wenxia , Feng Yu , Li Li , Liu Bin , Lin Feng , Jing Wen , Zhang Wenhua , Shen Like 
Published: December 2022

AbstractThe phosphatidylinositol‐specific phospholipase Cs (PI‐PLCs) catalyze the hydrolysis of phosphatidylinositols, which play crucial roles in signaling transduction during plant development and stress response. However, the regulation of PI‐PLC is still poorly understood. A previous study showed that a rice PI‐PLC, OsPLC1, was essential to rice salt tolerance. Here, we identified a 14‐3‐3 protein, OsGF14b, as an interaction partner of OsPLC1. Similar to OsPLC1, OsGF14b also positively regulates rice salt tolerance, and their interaction can be promoted by NaCl stress. OsGF14b also positively regulated the hydrolysis activity of OsPLC1, and is essential to NaCl‐induced activation of rice PI‐PLCs. We further discovered that OsPLC1 was degraded via ubiquitin‐proteasome pathway, and OsGF14b could inhibit the ubiquitination of OsPLC1 to protect OsPLC1 from degradation. Under salt stress, the OsPLC1 protein level in osgf14b was lower than the corresponding value of WT, whereas overexpression of OsGF14b results in a significant increase of OsPLC1 stability. Taken together, we propose that OsGF14b can interact with OsPLC1 and promote its activity and stability, thereby improving rice salt tolerance. This study provides novel insights into the important roles of 14‐3‐3 proteins in regulating protein stability and function in response to salt stress.
Elevated CO2 mitigates the impact of drought stress by upregulating glucosinolate metabolism in Arabidopsis thaliana
Authors: AbdElgawad Hamada , Zinta Gaurav , Hornbacher Johann , Papenbrock Jutta , Markakis Marios N. , Asard Han , Beemster Gerrit T. S. 
Published: December 2022

AbstractElevated CO2 (eCO2) reduces the impact of drought, but the mechanisms underlying this effect remain unclear. Therefore, we used a multidisciplinary approach to investigate the interaction of drought and eCO2 in Arabidopsis thaliana leaves. Transcriptome and subsequent metabolite analyses identified a strong induction of the aliphatic glucosinolate (GL) biosynthesis as a main effect of eCO2 in drought‐stressed leaves. Transcriptome results highlighted the upregulation of ABI5 and downregulation of WRKY63 transcription factors (TF), known to enhance and inhibit the expression of genes regulating aliphatic GL biosynthesis (e.g., MYB28 and 29 TFs), respectively. In addition, eCO2 positively regulated aliphatic GL biosynthesis by MYB28/29 and increasing the accumulation of GL precursors. To test the role of GLs in the stress‐mitigating effect of eCO2, we investigated the effect of genetic perturbations of the GL biosynthesis. Overexpression of MYB28, 29 and 76 improved drought tolerance by inducing stomatal closure and maintaining plant turgor, whereas loss of cyp79f genes reduced the stress‐mitigating effect of eCO2 and decreased drought tolerance. Overall, the crucial role of GL metabolism in drought stress mitigation by eCO2 could be a beneficial trait to overcome future climate challenges.
Multispecies comparison of host responses to Fusarium circinatum challenge in tropical pines show consistency in resistance mechanisms
Authors: Visser Erik A. , Kampmann Tamanique P. , Wegrzyn Jill L. , Naidoo Sanushka 
Published: December 2022

AbstractFusarium circinatum poses a threat to both commercial and natural pine forests. Large variation in host resistance exists between species, with many economically important species being susceptible. Development of resistant genotypes could be expedited and optimised by investigating the molecular mechanisms underlying host resistance and susceptibility as well as increasing the available genetic resources. RNA‐seq data, from F. circinatum inoculated and mock‐inoculated ca. 6‐month‐old shoot tissue at 3‐ and 7‐days postinoculation, was generated for three commercially important tropical pines, Pinus oocarpa, Pinus maximinoi and Pinus greggii. De novo transcriptomes were assembled and used to investigate the NLR and PR gene content within available pine references. Host responses to F. circinatum challenge were investigated in P. oocarpa (resistant) and P. greggii (susceptible), in comparison to previously generated expression profiles from Pinus tecunumanii (resistant) and Pinus patula (susceptible). Expression results indicated crosstalk between induced salicylate, jasmonate and ethylene signalling is involved in host resistance and compromised in susceptible hosts. Additionally, higher constitutive expression of sulfur metabolism and flavonoid biosynthesis in resistant hosts suggest involvement of these metabolites in resistance.
From Nomic Humeanism to Normative Relativism1
Authors: Sánchez Verónica Gómez 
Published: December 2022

AbstractIt is commonly thought that that the best system account of lawhood ((Mill (1843), Ramsey (1978)[fp. 1928], Lewis (1973)) makes available a nice explanation for why laws are ‘distinctively appropriate targets of scientific inquiry’ (Hall, 2015). The explanation takes the following general form: laws are especially valuable for agents like us because they efficiently encode a lot of valuable (non‐nomic) information in a tractable format. The goal of this paper is to challenge this style of explanation: I argue that the general principle it presupposes is in conflict with our best account of practical rationality. After considering and rejecting a number of proposals for dissolving the tension, I conclude that BSA proponents may need to scale back the explanatory ambitions of their theory; in particular, they may need to give up the hope of non‐circular explanations of the value of nomic information. I end by outlining some challenges for the humean world‐view that results after this shift.
Particle films improve photosynthesis of citrus trees under excess irradiance by reducing leaf temperature
Authors: Bernardi Lucas G. P. , Boaretto Rodrigo M. , Blain Gabriel Constantino , Mattos‐Jr Dirceu 
Published: December 2022

AbstractHigh irradiance and increased air temperature during extreme weather conditions affect tree crops and impact the yield and quality of fruits. Moreover, flowering and fruit set of Citrus are likely impaired by UV radiation and/or reduced carbon assimilation, which increase reactive oxygen species production and damage the leaf photosynthetic apparatus. Particle coating films sprayed on leaves have been offered as a way to minimize crop losses due to the climate change scenario, even though the extent of leaf protection is not characterized. We evaluated the use of two protective films on the oxidative stress and leaf photosynthesis of sweet orange trees exposed to varying daylight levels. Trees were maintained under full sun light, sprayed or not (control) with kaolin or calcium carbonate, and under reduced irradiance using either aluminum shade cloth 50% or anti‐UV transparent plastic. Kaolin or calcium carbonate reflected 20%–30% of the incident light on the leaf surface compared to leaves not sprayed and under full sunlight. Leaves with coating exhibited improved CO2 assimilation and photosystem II efficiency, and lower leaf temperatures over time. In addition, the coating protected leaves against excess irradiance due to dissipation of excess energy into the photosynthetic apparatus (NPQt). Nonenzymatic mechanisms for UV protection, such as carotenoids, were higher in full sun control plants than in leaf‐coated plants. Comparable responses were observed on trees maintained covered either by the cloth or the plastic film. Finally, we conclude that the use of suspension particles mitigates the harmful effects of excess UV irradiance and temperature in sweet orange trees.