bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal stability in the prevalence and pattern of co-occurring musculoskeletal pain among people with persistent low back pain: population-based data from the Norwegian HUNT Study, 1995 to 2019
Authors: Øverås Cecilie K. , Nilsen Tom I. L. , Søgaard Karen , Mork Paul J. , Hartvigsen Jan 
Published: July 2023

Abstract
People with persistent low back pain (LBP) often report co-occurring persistent musculoskeletal (MSK) pain in other body regions that may influence prognosis as well as treatment approaches and outcomes. This study describes the prevalence and patterns of co-occurring persistent MSK pain among people with persistent LBP based on consecutive cross-sectional studies over 3 decades in the population-based HUNT Study, Norway. The analyses comprised 15,375 participants in HUNT2 (1995-1997), 10,024 in HUNT3 (2006-2008), and 10,647 in HUNT4 (2017-2019) who reported persistent LBP. Overall, ∼90% of participants in each of the HUNT surveys with persistent LBP reported persistent co-occurring MSK pain in other body sites. The age-standardized prevalence of the most common co-occurring MSK pain sites was consistent across the 3 surveys: 64% to 65% report co-occurring neck pain, 62% to 67% report shoulder pain, and 53% to 57% report hip or thigh pain. Using latent class analysis (LCA), we identified 4 distinct patterns of persistent LBP phenotypes that were consistent across the 3 surveys: (1) “LBP only,” (2) “LBP with neck or shoulder pain,” (3) “LBP with lower extremity or wrist or hand pain,” and (4) “LBP with multisite pain,” with conditional item response probabilities of 34% to 36%, 30% to 34%, 13% to 17%, and 16% to 20%, respectively. In conclusion, 9 of 10 adults in this Norwegian population with persistent LBP report co-occurring persistent MSK pain, most commonly in the neck, shoulders, and hips or thighs. We identified 4 LCA-derived LBP phenotypes of distinct MSK pain site patterns. In the population, both the prevalence and pattern of co-occurring MSK pain and the distinct phenotypic MSK pain patterns seem stable over decades.
Cardiomyocytes, sphingolipids and cardio myotoxicity
Authors: Levin Malin C , Andersson Linda , Borén Jan 
Published: July 2023

Purpose of review
Sphingolipids are structurally diverse membrane lipids localized in lipid bilayers. Sphingolipids are not only important structural components of cellular membranes, but they are also important regulators of cellular trafficking and signal transduction and are implicated in several diseases. Here, we review the latest insights into sphingolipids and their role in cardiac function and cardiometabolic disease.

Recent findings
The underlying mechanisms linking sphingolipids to cardiac dysfunction are still not fully clarified. Sphingolipids, and in particular ceramides, have emerged as important players in lipotoxicity, mediating inflammation, impaired insulin signalling and apoptosis. In addition, recent findings highlight the importance of glycosphingolipid homeostasis in cardiomyocyte membranes, where they are required to maintain β-adrenergic signalling and contractile capacity to preserve normal heart function. Thus, glycosphingolipid homeostasis in cardiac membranes characterizes a novel mechanism linking sphingolipids to cardiac disease.

Summary
Modulation of cardiac sphingolipids may represent a promising therapeutic approach. Sustained investigation of the link between sphingolipids and cardiomyocyte function is therefore needed and we hope that this review may inspire researchers to further elucidate the action of these lipids.
Stakeholders’ perceptions and experiences of an outdoor activity project on children myopia prevention: a multiperspective qualitative study
Authors: Zhang Yiheng , Zeng Dumin , Zou Wenjie , Cheng Yu , Zhang Meifen , Gong Ni 
Published: July 2023

Abstract

Objective:
The current investigation sought to examine the experiences and perspectives of the project coordinators, participating parents, and children to identify strategies for enhancing children’s engagement and adherence to outdoor physical activities.

Methods:
A descriptive, qualitative study was conducted from October 2019 to December 2019 through in-depth interviews with 32 families who participated in the Community Child Myopia Prevention Project, 15 project volunteers, and 8 community organizers.

Results:
Five themes and 10 subthemes were identified to enhance children’s participation rate and adherence to the project. The 5 themes were as follows: (1) overcoming parental barriers, (2) attracting parental participation, (3) active support from parents, (4) creating a positive experience for children, and (5) integration into children’s daily lives.

Conclusions:
Empowering parents and children by meeting their needs, creating innovative activities, and connecting them with community social networks support the successful integration of the outdoor activity program into their daily lives. The sharing and integration of community resources through community empowerment can provide a framework for developing future community interventional projects.
Simplified soft tissue coverage of the distal lower extremity: The reverse sural flap
Authors: Puneky George A. , Batchler Kathryn A. , Kollapaneni Sai S. , Blair James A. , Davis Jana M. 
Published: July 2023

Summary:
Soft tissue defects involving the distal lower extremity present challenging problems for orthopaedic surgeons to manage. Historically, wounds not amenable to primary closure have necessitated assistance from multidisciplinary teams using plastic surgeons to obtain adequate soft tissue coverage through rotational flap or free tissue transfer procedures. Techniques related to soft tissue rearrangement and local rotational flap coverage have advanced over the years with a growing knowledge of local anatomy and vasculature. The reverse sural flap may be performed to cover soft tissue defects within 10 cm of the foot or ankle region, negating the need for microvascular intervention. The simplistic nature of the reverse sural flap is appealing to orthopaedic surgeons as a means to provide timely patient care without additional support because it does not require microvasculature work or the need for intraoperative microscopes and has been popularized among orthopaedic trauma surgeons as a necessary tool to possess. Here, we discuss the reverse sural flap to include history, relevant anatomy, clinical indications, and a description of the technique for application.
The use of xenogenic dermal matrices in the context of open extremity wounds: where and when to consider?
Authors: Chintalapudi Nainisha , Rice Olivia M. , Hsu Joseph R. 
Published: July 2023

Summary:
Optimal treatment of orthopaedic extremity trauma includes meticulous care of both bony and soft tissue injuries. Historically, clinical scenarios involving soft tissue defects necessitated the assistance of a plastic surgeon. While their expertise in coverage options and microvascular repair is invaluable, barriers preventing collaboration are common. Acellular dermal matrices represent a promising and versatile tool for orthopaedic trauma surgeons to keep in their toolbox. These biological scaffolds are each unique in how they are used and promote healing. This review explores some commercial products and offers guidance for selection in different clinical scenarios involving traumatic wounds.
How to get the most out of your gastrocnemius and soleus flaps
Authors: Matuszewski Paul E. , Ulrich Gary L. 
Published: July 2023

Summary:
Gastrocnemius and soleus flaps represent the workhorse local flaps to cover soft tissue defects of the proximal 1/3 and middle 1/3 of the leg, respectively. An important consideration before conducting a local flap is whether the flap can provide adequate coverage. The utility of the gastrocnemius flap can be increased using multiple techniques to increase the arc of rotation including the posterior midline approach, dissection at the pes anserinus and medial femoral condyle origin, scoring the fascia, and inclusion of a skin paddle. Concerning the soleus flap, the hemisoleus flap represents a technique to increase the arc of rotation. With a soleus flap, one must consider the soft tissue defect location, size, and perforator blood supply because these factors influence what soleus flap technique to use. This article discusses how to make the most out of gastrocnemius flaps and soleus flaps regarding maximizing coverage and ensuring successful flap outcome.
Burden of influenza in the elderly: a narrative review
Authors: Conrad Anne , Valour Florent , Vanhems Philippe 
Published: July 2023

Purpose of review
This review provides an update on specificities of influenza in older adults (≥65-year-old), including epidemiology, burden in terms of hospitalization and mortality, extra-respiratory complications and specific challenges of prevention.

Recent findings
In the past 2 years, influenza activity was drastically reduced by barrier measures implemented during the COVID-19 pandemic. A recent French epidemiological study covering 2010–2018 epidemic seasons estimated that 75% of costs induced by influenza-associated hospitalizations and complications were attributable to older adults, a population bearing more than 90% of influenza-associated excess mortality.
In addition to their age, comorbidities and reduced vaccine response, long-term facility residents are at risk for nosocomial outbreaks. Beyond respiratory complications, influenza triggers acute myocardial infarction and ischemic stroke. Influenza might drive significant functional loss in frail older adults, which can lead to “catastrophic” or severe disability in up to 10% of patients. Vaccination remains the cornerstone of prevention, with enhanced immunization strategies (i.e., high-dose or adjuvanted formulations) to be largely implemented in older adults. Efforts to increase influenza vaccination uptake during the COVID-19 pandemic should be consolidated.

Summary
Burden of influenza in the elderly is largely under-recognized, especially the cardiovascular complications and the impact on functional status, justifying more effective preventive strategies.
Genetic and molecular analyses of candidate germlineBRIP1/FANCJvariants implicated in breast and ovarian cancer
Authors: Milano Larissa , Alenezi Wejdan M. , Fierheller Caitlin T. , Serruya Corinne , Revil Timothée , Oros Kathleen K. , Bruce Jeffrey , Spiegelman Dan , Pugh Trevor , Masson Anne-Marie Mes- , Provencher Diane , Foulkes William D. , Haffaf Zaki El , Rouleau Guy , Bouchard Luigi , Greenwood Celia M.T. , Ragoussis Jiannis , Tonin Patricia N. , Masson Jean-Yves 
Published: July 2023

ABSTRACTFive rare variants inBRIP1/FANCJ, initially reported in ovarian (OC) or breast (BC) cancer cases by the adult hereditary cancer clinics, were investigated for their candidacy as clinically relevant variants. These variants were investigated genetically in a population exhibiting genetic drift and molecularly assayed for biological impact. Using in silico tools, population-based genetic databases and other resources, three of the five reportedBRIP1variants were likely to be damaging: c.797C>T; p.Thr266Met, c.2087C>T; p.Pro696Leu and c.2990_2993delCAAA; p.Thr997ArgfsTer61. The carrier frequencies ranged from 0-0.7% in ancestry defined cancer groups comprised of 47 OC families, 49 hereditary breast and ovarian cancer syndrome families, 142 hereditary breast cancer syndrome families, 435 sporadic OC cases and 563 sporadic BC cases and 0-0.2% in 1025 population-matched controls. Multiple carriers of the same variants were identified in additional population-matched cancer cases. Of the five reportedBRIP1variants, p.Thr266Met, p.Pro696Leu and p.Thr997ArgfsTer61, which were predicted to be damaging, conferred cellular sensitivity to mitomycin C and cisplatin unlike p.Ser139Ala and p.Ala406Ser. Collectively, our investigation implicatesBRIP1c.797C>T; p.Thr266Met, c.2087C>T; p.Pro696Leu and p.Thr997ArgfsTer61 as deleterious variants in OC and BC.
Mosaic-PICASSO: accurate crosstalk removal for multiplex fluorescence imaging
Authors: Cang Hu , Liu Yang , Xing Jianhua 
Published: July 2023

AbstractUltra-multiplexed fluorescence imaging has revolutionized our understanding of biological systems, enabling the simultaneous visualization and quantification of multiple targets within biological specimens. A recent breakthrough in this field is PICASSO, a mutual-information-based technique capable of demixing up to 15 fluorophores without their spectra, thereby significantly simplifying the application of ultra-multiplexed fluorescence imaging. However, this study has identified a limitation of mutual information-based techniques. They do not differentiate between spatial colocalization and spectral mixing. Consequently, mutual information-based demixing may incorrectly interpret spatially co-localized targets as non-colocalized, leading to overcorrection. We found that selecting regions within a multiplex image with low spatial similarity for measuring spectroscopic mixing results in more accurate demixing. This method effectively minimizes overcorrections and promises to accelerate the broader adoption of ultra-multiplex imaging.
Defining the data gap: what do we know about environmental exposure, hazards and risks of pharmaceuticals in the European aquatic environment?
Authors: Spilsbury F.D. , Inostroza P.A. , Svedberg P. , Cannata C. , Ragas A.M.J. , Backhaus T. 
Published: July 2023

AbstractActive pharmaceutical ingredients (APIs) and their transformation products inevitably enter waterways where they might cause adverse effects to aquatic organisms. Identifying the potential risks of APIs in the environment is therefore a goal and current strategic direction of environmental management described in the EU Strategic Approach to Pharmaceuticals in the Environment and the Green Deal. This is challenged by a paucity of monitoring and ecotoxicity data to adequately describe risks.In this study we analyze measured environmental concentrations (MECs) of APIs from 5933 sites in 25 European countries as documented in the EMPODAT database or collected by the German Environment Agency for the time period between 1997 to 2020. These data were compared with empirical data on the ecotoxicity of APIs from the U.S. EPA ECOTOX database. Although 1763 uniquely identifiable APIs are registered with the European Medicines Agency (EMA) for sale in the European Economic Area (EEA), only 312 (17.7%) of these are included in publicly available monitoring data, and only 36 (1.8%) compounds have sufficient ecotoxicological data to perform an EMA-compliant ERA. Among the 27 compounds with sufficient exposure and hazard data to conduct a single substance risk assessment according to EMA guidelines, four compounds (14.8%) had a median risk quotient (RQ) > 1. Endocrine disruptors had the highest median RQ, with 7.0 and 5.6 for 17α-ethinyl-estradiol and 17β-estradiol respectively.A comparison ofin-silicoand empirical data for 72 APIs demonstrated the high protectiveness of the current EMA guidelines, with predicted environmental concentrations (PECs) exceeding median MECs in 98.6% of cases, with a 100-fold median increase.This study describes the data shortfalls hindering an accurate assessment of the risk posed to European waterways by APIs, and identifies 68 APIs for prioritized inclusion in monitoring programs, and 66 APIs requiring ecotoxicity testing to fill current data gaps.Highlights1763 medicines are EMA-approved for sale in the EEAThe data gap is 1201 APIs (68%) that have no ecotoxicity or public monitoring dataOnly 27 APIs (1.5%) have sufficient empirical data for risk assessment.ERA using 23 years of EU monitoring data shows four compounds with a median RQ > 1Data gap APIs prioritized for monitoring programs (68) and ecotoxicity testing (66)
Cofilin-Driven Nuclear Deformation Drives Dendritic Cell Migration through the Extracellular Matrix
Authors: Warner Harry , Franciosa Giulia , van der Borg Guus , Faas Felix , Koenig Claire , de Boer Rinse , Classens René , Maassen Sjors , Baranov Maksim , Mahajan Shweta , Dabral Deepti , Coenen Britt , Bianchi Frans , van Hilten Niek , Risselada Herre Jelger , Roos Wouter H. , Olsen Jesper , Cano Laia Querol , van den Bogaart Geert 
Published: July 2023

AbstractTo mount an adaptive immune response, dendritic cells must process antigens, migrate to lymph nodes and form synapses with T cells. Critical to 3D migration and mechano-sensing is the nucleus, which is the size-limiting barrier for navigation through gaps in the extracellular matrix. Here, we show that inflammatory activation of dendritic cells leads to the nucleus becoming spherically deformed, adopting a raison-like shape and enables dendritic cells to overcome the typical 2 – 3-micron pore limit for 3D-migration. We show that the nuclear shape-change is partially attained through reduced cell adhesion, whereas improved migration through extracellular matrix is achieved through reprogramming of the actin cytoskeleton. Specifically we show that cofilin-1 is phosphorylated at serine 41 drives the assembly of a Cofilin-ActoMyosin (CAM)-ring proximal to the nucleus and enhancing migration through 3D collagen gels. In summary, these data describe novel signaling events through which dendritic cells simultaneously deform their nucleus and enhance their migratory capacity; molecular events that may be re-capitulated in other contexts such as wound healing and cancer.
Application of artificial intelligence (AI) in the area of corrosion protection
Authors: Lin Zhifeng , Zhang Wei , Li Jiawei , Yang Jing , Han Bing , Xie Peng 
Published: July 2023

Purpose
As a common form of failure in industry, corrosion causes huge economic losses. At present, with the development of computational techniques, artificial intelligence (AI) is playing a more and more important role in the field of scientific research. This paper aims to review the application of AI in corrosion protection research.

Design/methodology/approach
In this paper, the role of AI in corrosion protection is systematically described in terms of anticorrosion materials and methods, corrosion image recognition and corrosion life prediction.

Findings
With efficient and in-depth data processing methods, AI can rapidly advance the research process in terms of anticorrosion materials and methods, corrosion image recognition and corrosion life prediction and save on costs.

Originality/value
This paper summarizes the application of AI in corrosion protection research and provides the basis for corrosion engineers to quickly and comprehensively understand the role of AI and improve production processes.
User’s intention towards the use of digital libraries: a post COVID-19 scenario
Authors: Sujood  , Siddiqui Samiha , Nafees Sehar , Bano Naseem 
Published: July 2023

Purpose
Following a crucial COVID-19 pandemic lockdown, the coronavirus has affected every academic institution, particularly libraries and information centres. To address this unprecedented scenario, libraries’ staff has decided to provide their services via digital access while staying close to the users. To predict users’ intention to use digital libraries after COVID-19, the authors combined the technology acceptance model (TAM), the theory of planned behaviour (TPB) and perceived risk.

Design/methodology/approach
Data were collected via a paper-based questionnaire using a convenient sampling method which was distributed at two major libraries; Maulana Azad Library, Aligarh Muslim University and Dr Zakir Husain Library, Jamia Millia Islamia in India.

Findings
Empirical findings suggested that all the proposed hypotheses were supported, and the integrated model had strong explanation power as the proposed model explained a 74.5% variance in users’ intention to use digital libraries after COVID-19.

Research limitations/implications
This study offers substantial information to librarians, digital libraries, universities, institutes and other stakeholders and sheds light on the potential for a developing nation to transition to an economy with a strong digital infrastructure. The scope of the study is constrained to the users in India only, hence, leading to the possibility that it may be challenging to generalize the findings.

Originality/value
According to the best of the authors’ knowledge, it is one of the few studies to predict users’ intentions for using digital libraries after COVID-19 by applying the integrated model of TPB and TAM in an emerging economy. It helped understand the users’ attitudes towards using the digital services and resources available at the respective libraries. It also contributed considerably to the argument that users have grown accustomed to harnessing digital libraries during the post-COVID-19 period.
Major powers’ management of complex peace relationships
Authors: Bayer Reşat 
Published: July 2023

Purpose
This study aims to contribute to discussions on peace between hostile nonmajor powers by focusing on the behavior of major powers. Specifically, alliances between nonmajor and major powers are explored to determine whether such ties contribute to transitions to higher levels of peace. Moreover, systemic factors involving power dynamics and relationships between major powers are also evaluated.

Design/methodology/approach
Multiple data sets which altogether covered the era from 1816 to 2010 were analyzed. All pairs of countries that were former foes were considered. Cox hazard regression was conducted.

Findings
Systemic instability is influential at transitions from lowest levels of peace for nonmajor power dyads. Eras where major powers are operating multilaterally appear to play a highly limited role in nonmajor powers attaining stable peace. However, alliances with major powers are relatively more crucial in these discussions for nonmajor powers and contribute to higher levels of peace being attained by nonmajor powers.

Research limitations/implications
Further research in particular with case studies can help to elucidate and extend the statistical findings.

Practical implications
Based on the findings, the design and operations of alliances can create more space to hear a wider range of issues that allies can be facing.

Originality/value
While major powers clearly have considerable capacity and global outreach, there has been little attention to whether and how they contribute to former foes attaining higher quality of peace.