bluuebunny/crossref_metadata_2025_split huggingface dataset:
Washback Effect of Vocational High School Final Examination: Indonesian EFL Teachers' and Students' Voices
Authors: Alka Wensi 
Published: February 2023

The English final examination is no longer a high-stake test since National Examination (NE) was abolished in 2021 and replaced with the Ujian Satuan Pendidikan (USP). Therefore, this study explores the washback effects experienced by Indonesian EFL teachers and students and discovers teachers’ and students’ perceptions of the implementation of USP. Six participants, three Indonesian English Foreign Language (EFL) teachers, and three Public Vocational High School students in Singosari were interviewed to meet the research goals. The findings indicated that focusing on teaching to the test, cheating, and feelings and attitudes were the washback effects of the English final examination in implementing USP. Then, the English final examination still harms the teaching and learning process and teachers’ and students’ feelings and attitudes, even though it is not a high-stake test. Besides, the implementation of USP also reduces the washback effect of the English final examination.
Elaboração e aplicação de revestimentos comestíveis com adição de iogurte de kefir em maçãs e uvas
Authors: Holthausen Maria Antonia Cardoso , Castilho Gustavo Bressa , Madalozzo Elisângela Serenato 
Published: February 2023

No Brasil a maioria das frutas tem um rápido processo de maturação. Uma alternativa para preservar estas frutas são os revestimentos comestíveis a base de kefir, que possuem alta atividade antimicrobiana. Este trabalho tem como objetivo a elaboração de revestimentos comestíveis utilizando iogurte de kefir, aplicando em maçãs e uvas para analisar o aumento da shelf life. Foram obtidas duas formulações de revestimentos com iogurte de kefir (0,5 litros e 1 litro) que foram aplicados nas frutas. As mesmas foram armazenadas por um período de onze dias e submetidas às análises físico-químicas e microbiológicas. Os resultados obtidos demonstraram que o revestimento com 1L de iogurte de kefir, fez com que as maçãs e uvas junto com a refrigeração, conseguissem menor porcentagem de perda de massa. Nas uvas o revestimento com 0,5L em temperatura ambiente, foi o que obteve os melhores resultados para ph (3,06) e acidez (13,29 mL NaOH.100 g-1), ambos tiveram uma diferença significativa das outras amostras. Já para as maçãs, o mesmo revestimento em temperatura ambiente apresentou um valor de 4,42 para pH, sendo significativamente igual as outras amostras, e 0,63 para acidez, sendo diferente significativamente das outras amostras. Para as análises microbiológicas, o revestimento com 1L de iogurte de kefir obteve melhores resultados para o controle microbiológico das maçãs e para as uvas o revestimento com 0,5L obteve resultados melhores. Assim conclui-se que os revestimentos a base de iogurte de kefir foram eficazes, nesse estudo, para preservar as maçãs e uvas por um período prolongado.
Aplicabilidade do Lean Healthcare no serviço de emergência médica
Authors: Oliveira Jefferson Ribeiro de , Cavalcanti Junior Geraldo Barroso , Silva José Adailton da 
Published: February 2023

Introdução: As mudanças constantes no mercado e nas organizações exigiram que as empresas se adaptassem para suprir as necessidades dos consumidores. Dentro desse processo, o Lean surge como alternativa de ferramenta de gestão, trazendo em seus princípios a redução de desperdícios, custos e riscos, além de proporcionar uma melhoria na qualidade da prestação de serviço. Objetivo: Sintetizar as evidências da aplicabilidade do método Lean Healthcare no setor de emergência médica. Métodos: Trata-se de uma revisão integrativa de literatura de natureza aplicada sobre o método Lean Healthcare no setor da saúde. A coleta de dados foi realizada nos bancos de dados nos meses de janeiro de 2021 a abril de 2022 através de um formulário estruturado com especificações de acordo com seu título, autores e ano, abordagem metodológica e contribuição do estudo. Resultados: constatou-se mediante a pesquisa que a aplicação exitosa do método Lean Healthcare no setor emergência é um grande fator contribuinte na gestão, sanando deficiências encaradas neste cenário e fornecendo estratégias visando melhorar a eficiência da prestação de serviço aos pacientes. Os autores pesquisados são unânimes ao relatarem que o método permite que o atendimento flua de forma satisfatória, porém existe a necessidade de que todos os setores do hospital o adotem. Conclusão: Os estudos mostraram que, embora a aplicabilidade do Lean Healthcare seja indiscutível, existe a necessidade de novas pesquisas voltadas para a análise real da sua eficácia nos departamentos de emergência médica para que seus efeitos possam ser minuciosamente desenhados na literatura.
O cuidado familiar a crianças e adolescentes com fibrose cística
Authors: Souza Nayla Kethellyn Gonçalves de , Petruccelli Gabriele , Olivatto Gabriela Marsola , Bonelli Maria Aparecida 
Published: February 2023

O estudo teve como objetivo conhecer a experiência de famílias no cuidado de crianças/adolescentes com fibrose cística. Trata-se de um estudo descritivo, exploratório e de abordagem qualitativa, realizado com nove famílias de crianças e adolescentes com fibrose cística, residentes em municípios do estado de São Paulo, no período de setembro de 2020 a janeiro de 2021. Utilizou-se o Cuidado Centrado na Família como conceito teórico, a Análise de Conteúdo de Bardin como referencial metodológico, e a entrevista aberta online enquanto estratégia de coleta de dados. A partir da análise dos dados foi possível apreender três categorias temáticas: “Deparando-se com a fibrose cística”; “Cuidados à criança/adolescente com fibrose cística e suas repercussões familiares”; e “O apoio na trajetória de cuidado da criança/adolescente com fibrose cística”. Concluiu-se que existe uma vida de dependência, tanto do familiar quanto do fibrocístico, relacionada à doença e ao desgaste emocional e físico, sendo que todos os cuidados no seu dia-a-dia precisam ser realizados de forma precisa e ampla. Dessa forma, ressalta-se a importância da rede assistencial, da qual a equipe multidisciplinar e o enfermeiro fazem parte, para que a família tenha como foco a atenção ao indivíduo, proporcionando um estilo de vida humano, com promoção à saúde e qualidade de vida.
MEMAHAMI MAQASHID ASY-SYARIAH PADA AYAT RADHAâ€™AH PERSPEKTIF KEADILAN GENDER
Authors: Ummah Siti Rohmatul 
Published: February 2023

AbstrakÂ Perintah pemberian ASI merupakan salah satu bentuk pemeliharaan terhadap bayi. Dalam istilah fikih, pemberian ASI diatur dalam hukum radhaâ€™ah. Salah satu dasar pelaksanaan radhaâ€™ah adalah ayat 233 surat al-Baqarah (2). Selain menjelaskan perintah menyusui, ayat ini juga mengandung perintah pemberian nafkah bagi ibu menyusui. Dengan maksud mengungkap tujuan syariat yang tersirat dalam perintah di ayat ini dan hubungan tujuan tersebut dengan keadilan gender penelitian ini dilakukan dengan mengikuti kaidah penelitian kualitatif deskriptif yang menjabarkan konsep hasil pembacaan, pengumpulan dan analisis data yang bersumber pada data di perpustakaan. Hasil penelitian ini menjelaskan bahwa dalam ayat ini penggunaan panggilan umum bagi ayah, ibu dan anak bertujuan untuk menyatakan bahwa kewajiban memberi dan hak menerima ASI berlaku secara umum bagi semua orang tanpa membedakan gendernya. Hasil lain yang peneliti dapat disini adalah bahwa dalam kegiatan pemberian ASI terdapat kelima jaminan perlindungan yang disebut sebagai maqashid asy-syariâ€™ah paling penting. Dari kaca mata keadilan gender, kandungan ayat ini berhasil memberikan tugas yang sesuai dengan kemampuan dan kondisi masing-masing gender secara adil tanpa memihak salah satu di antara keduanya.Â Kata Kunci : Maqashid asy-syariâ€™ah, Ayat radhaâ€™ah, dan Keadilan gender.Â AbstractThe order for breastfeeding is a form of caring for the baby. In fiqh terms, breastfeeding is regulated in the law of radha'ah. One of the bases for implementing radha'ah is verse 233 surah al-Baqarah (2). Apart from explaining the commandment for breastfeeding, this verse also contains instructions for providing support for breastfeeding mothers. To reveal the objectives of the Shari'a implied in the commands in this verse and the relationship between these goals and gender justice, this research was conducted by following the principles of descriptive qualitative research which outlines the concept of reading, collecting, and analyzing data sourced from data in the library. The results of this study explain that in this verse the use of general calls for father, mother, and child aims to state that the obligation to give and the right to receive breastfeeding applies in general to all people regardless of gender. Another result that the researchers got here is that in the activity of breastfeeding there are five guarantees of protection which are called the most important objectives of the Shari'a. From the point of view of gender justice, the content of this verse succeeds in giving a task that is regarding the abilities and conditions of each gender fairly without taking sides with either of the two.Keywords: The objectives of the Shari'a, Verse of radhaâ€™ah, and Gender justice.
DAMPAK PANDEMI COVID-19 TERHADAP INTENSITAS PERCERAIAN, MASALAH DAN PENYELESAIANNYA
Authors: Saputra Megi 
Published: February 2023

ABSTRAKÂ Tulisan ini bertujuan untuk mengekplorasi bagaimana Intesitas penceraian terjadi di Indonesia serta sebeb-sebab utamanya, karena sebagimana diketahui bahwa intesitas perceraian selama masa pandemi meningkat terutama di 3 provinsi teratas yakni Jawa Barat, Jawa Tengah dan Jawa Timur. Angka intesitas perceraian meninggkat hingga angka 5%. Kondisi ini memprihatinkan karena akan berdampak bagi kehidupan berbangsa, keluarga dan anak-anak. Oleh karena itu dalam artiket ini akan ditawarkan alternatif penyelesain masalah keluarga. Tulisan ini dilakukan dengan menggali informasi dan data dari sumber Pustaka, artikel dan sumber-sumber terkait pembahasan. bertujuan untuk mengekplorasi bagaimana solusi dan penyelesaian agar perceraian dapat diminimalisir atau dihindari. Sebagai hasil dari penelitian ini penulis menawarkan tiga alternatif solusi, sebagai upaya preventif terjadinya perceraian yakni 1). Melalui prinsip-prinsip perkawinan; 2). Melalui Tujuan Perkawinan; 3). Melalui Komunikasi Keluarga.Kata Kunci : Keluarga, dampaknya pada masa Pandemi Covid-19, alternatif Penyelesaian.Â
Narasi dan Representasi Kearifan Lokal dalam Video Promosi Pariwisata The Heartbeat Of Toba
Authors: Pamungkas Adi 
Published: February 2023

Abstrak Sebagai materi audio visual, video sering digunakan sebagai alat promosi pariwisata karena kemampuannya dalam menyimulasikan citra dari sebuah destinasi wisata sehingga dapat mengenalkannya dengan baik kepada audiens. Tidak hanya menampilkan visual destinasi wisatanya saja, video promosi pariwisata juga dapat mengomunikasikan konten khusus lainnya guna memberikan perspektif yang lebih kaya, salah satunya tentang kearifan lokal. Penelitian ini bertujuan untuk mengetahui bagaimana video promosi The Heartbeat of Toba menarasikan konten kearifan lokal guna memperkaya storytelling sehingga dapat menjadi video promosi pariwisata yang tidak hanya menampilkan keindahan landscape destinasi tetapi juga menawarkan pengalaman berwisata yang lebih mendalam kepada audiensnya. Penelitian ini merupakan penelitian kualitatif dengan metode analisis isi teks media. Peneliti menggunakan teori paradigma naratif guna menganalisis narasi kearifan lokal dalam cerita yang disampaikan serta menggunakan teori semiotika guna mengetahui makna yang terkandung di dalamnya. Temuan penelitian memperlihatkan bahwa konten kearifan lokal dalam video disampaikan melalui narasi terstruktur yang rasional serta melalui representasi ikonik, indeksikal dan simbolik dalam teks yang digunakan. Penelitian lebih lanjut perlu dilakukan guna mengetahui efektivitas konten kearifan lokal dalam video promosi pariwisata terhadap persepsi audiens dalam menimbulkan niat untuk berwisata ke destinasi yang dipromosikan. Kata Kunci: analisis naratif, kearifan lokal, representasi, storytelling, video promosi AbstractAs audio visual material, videos are used as a tourism promotion tool refers to its ability to simulate the visual of the destination so they can introduce it well to the audience. Not only visualizing the destinations, but a tourism promotion video can also communicate particular content to provide richer perspectives, one of them is about local wisdom. This study aimed to find out how promotional video The Heartbeat of Toba narrates local wisdom to enrich their storytelling so the video not only visualizing the beauty of the landscape but also offers a fulfilling travel experience to the audience. This study was a qualitative content analysis refers to media texts. The author used the theory of the narrative paradigm to analyze the content of local wisdom in the stories also used the theory of semiotics to find out the meaning contained in it. The findings show that the content of local wisdom in the video was narrated through rational and structured narratives as well as through iconic, indexical, and symbolic representations texts. Further research is needed to determine the effectiveness of local wisdom content in tourism promotion videos on audience perceptions in generating intentions to travel to the promoted destinations. Keywords: local wisdom, narrative analysis, promotional video, representation, storytelling
Analisis Karakter “Si Korona” pada Buku Digital Kartun Edukasi Virus Corona untuk Anak-Anak di Tengah Pandemi
Authors: Handriyotopo Handriyotopo 
Published: February 2023

AbstrakCovid-19 (Corona Virus Disease 2019) sangat mengkawatirkan bagi sendi umat manusia saat ini di dunia. Usaha untuk menyadarkan pentingnya protokol saat new normal telah banyak dilakukan. Menyadarkan pentingnya menjaga kesehatan tentang pengetahuan virus corona dibutuhkan oleh anak-anak yang juga rentan dengan virus ini. Edukasi pengetahuan tentang virus corona diperlukan bagi anak seperti yang dilakukan oleh HIMPSI (Himpunan Psikologi Indonesia) dengan membuat kartun secara online perlu diapresiasi. Penyadaran virus corona dengan pendekatan kartun pada anak sangat menarik untuk dikaji di tengah maraknya info virus corona dalam bentuk infografis dan motion graphic ataupun iklan layanan masyarakat tentang menjaga protokol kesehatan seperti patuh pada ibu dengan 3M. Penelitian ini menggunakan metode kualitatif untuk menemukan data-data penting dalam melakukan analisis deskriptif. Melalui pendekatan karakter kartun melalui proses mimikri dan retorika visual, untuk menemukan makna karakter Si Korona. Temuan penting untuk menciptakan karakter adalah melalui proses mimikri sebagai metode untuk membangun karakter tokoh utama kartun Si Korona. Watik Ideo dan Luluk N. secara reorika visual berhasil membuat karakter Si Korona yang sederhana agar anak-anak dapat memahami tentang virus corona untuk menyadarkan pemahaman covid-19 pada anak. Kata kunci: Edukasi Anak, Kartun, Si Korona, Virus Corona AbstractCovid-19 (Corona Virus Disease 2019) is very worrying for the joints of humanity today in the world. Many Covid-19 (Corona Virus Disease 2019) is very worrying for the joints of humanity today in the world. Many efforts have been made to make the protocols aware of the importance of the new normal. Awareness of the importance of maintaining health about knowledge of the coronavirus is needed by children who are also vulnerable to this virus. Education on knowledge about the coronavirus is needed for children, as done by HIMPSI (Indonesian Psychological Association) making cartoons online needs to be appreciated. Awareness of the coronavirus with a cartoon approach to children is very interesting to study amidst the rise of information on the coronavirus in the form of infographics and motion graphics or public service advertisements about maintaining health protocols such as obeying mothers with 3M. This study uses qualitative methods to find important data in conducting a descriptive analysis. Through a cartoon character approach through mimicry and visual rhetoric processes, to find the meaning of the character Si Corona. An essential finding for creating characters is through the process of mimicry as a method for building the character of the main character of the cartoon Si Corona. Watik Ideo and Luluk N. visually rhetorically succeeded in creating a simple Corona character so that children can understand the corona virus to awaken their children to an understanding of Covid-19. Keywords: Children Education, Cartoon, Corona Virus, Si Korona
Characterization of the immune cell landscape in CRC: Clinical implications of tumour-infiltrating leukocytes in early- and late-stage CRC
Authors: Bazzi Zainab Ali , Sneddon Sophie , Zhang Peter G. Y. , Tai Isabella T. 
Published: February 2023

IntroductionColorectal cancer (CRC) is the third leading cause of cancer-related deaths globally. Tumour-infiltrating leukocytes play an important role in cancers, including CRC. We therefore sought to characterize the impact of tumour-infiltrating leukocytes on CRC prognosis.MethodsTo determine whether the immune cell profile within CRC tissue could influence prognosis, we employed three computational methodologies (CIBERSORT, xCell and MCPcounter) to predict abundance of immune cell types, based on gene expression. This was done using two patient cohorts, TCGA and BC Cancer Personalized OncoGenomics (POG).ResultsWe observed significant differences in immune cell composition between CRC and normal adjacent colon tissue, as well as differences in based on method of analysis. Evaluation of survival based on immune cell types revealed dendritic cells as a positive prognostic marker, consistently across methodologies. Mast cells were also found to be a positive prognostic marker, but in a stage-dependent manner. Unsupervised cluster analysis demonstrated that significant differences in immune cell composition has a more pronounced effect on prognosis in early-stage CRC, compared to late-stage CRC. This analysis revealed a distinct group of individuals with early-stage CRC which have an immune infiltration signature that indicates better survival probability.ConclusionsTaken together, characterization of the immune landscape in CRC has provided a powerful tool to assess prognosis. We anticipate that further characterization of the immune landscape will facilitate use of immunotherapies in CRC.
Systematic review and meta-analysis of the current literature on tocilizumab in patients with refractory Takayasu arteritis
Authors: Kang Limei , Liu Yang , Luo Zhongling , Zhou Yueyuan , Chen Bo , Yin Geng , Xie Qibing 
Published: February 2023

ObjectiveTo present the pooled quantitative evidence of baseline characteristics and clinical outcomes of tocilizumab (TCZ) in patients with refractory Takayasu arteritis (TAK).MethodsA comprehensive systematic review and meta-analysis was performed on all available studies retrieved from the MEDLINE, Embase, and Cochrane databases, using TCZ in patients with refractory TAK. We applied the commands metan and metaprop_one in Stata Software to pool overall estimates of continuous data and binomial data, respectively. A random-effects model was recruited for analysis.ResultsNineteen studies with 466 patients were included in this meta-analysis. The mean age at implementation of TCZ was 34.32 years. Female sex and Numano Type V were the most prominent baseline characteristics. During the 12-month follow-up when receiving TCZ treatment, pooled CRP was 1.17 mg/L (95% confidence interval [CI] -0.18-2.52), pooled ESR was 3.54 mm/h (95% CI 0.51-6.58), and pooled glucocorticoid dose was 6.26 mg/d (95% CI 4.24-8.27). Approximately 76% (95% CI 58-87%) of patients achieved a decrease in glucocorticoid dosage. Meanwhile, patients with TAK had a remission rate of 79% (95% CI 69-86%), a relapse rate of 17% (95% CI 5-45%), an imaging progress rate of 16% (95% CI 9-27%), and a retention rate of 68% (95% CI 50-82%). Adverse events occurred in 16% (95% CI 5-39%) of patients, and infection was the most common adverse event, with a rate of 12% (95% CI 5-28%).ConclusionTCZ treatment can provide favorable outcomes in terms of inflammatory markers, steroid-sparing effects, clinical response, drug retention and minimizing adverse effects for patients with refractory TAK.
Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21low B cells in hepatitis C virus-cured mixed cryoglobulinemia
Authors: Del Padre Martina , Marrapodi Ramona , Minafò Ylenia A. , Piano Mortari Eva , Radicchio Giovanna , Bocci Chiara , Gragnani Laura , Camponeschi Alessandro , Colantuono Stefania , Stefanini Lucia , Basili Stefania , Carsetti Rita , Fiorilli Massimo , Casato Milvia , Visentini Marcella 
Published: February 2023

IntroductionHepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of B cells expressing B cell receptors (BCRs), often encoded by the VH1-69 variable gene, endowed with both rheumatoid factor (RF) and anti-HCV specificity. These cells display an atypical CD21low phenotype and functional exhaustion evidenced by unresponsiveness to BCR and Toll-like receptor 9 (TLR9) stimuli. Although antiviral therapy is effective on MC vasculitis, pathogenic B cell clones persist long thereafter and can cause virus-independent disease relapses.MethodsClonal B cells from patients with HCV-associated type 2 MC or healthy donors were stimulated with CpG or heath-aggregated IgG (as surrogate immune complexes) alone or in combination; proliferation and differentiation were then evaluated by flow cytometry. Phosphorylation of AKT and of the p65 NF-kB subunit were measured by flow cytometry. TLR9 was quantified by qPCR and by intracellular flow cytometry, and MyD88 isoforms were analyzed using RT-PCR.DiscussionWe found that dual triggering with autoantigen and CpG restored the capacity of exhausted VH1-69pos B cells to proliferate. The signaling mechanism for this BCR/TLR9 crosstalk remains elusive, since TLR9 mRNA and protein as well as MyD88 mRNA were normally expressed and CpG-induced phosphorylation of p65 NF-kB was intact in MC clonal B cells, whereas BCR-induced p65 NF-kB phosphorylation was impaired and PI3K/Akt signaling was intact. Our findings indicate that autoantigen and CpG of microbial or cellular origin may unite to foster persistence of pathogenic RF B cells in HCV-cured MC patients. BCR/TLR9 crosstalk might represent a more general mechanism enhancing systemic autoimmunity by the rescue of exhausted autoreactive CD21low B cells.