bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic management of sinonasal tumours in the Nordic university hospitals: a survey
Authors: Korsström Carl , Lilja Markus , Hammarstedt-Nordenvall Lalle , Mäkitie Antti , Haapaniemi Aaro 
Published: September 2023

Abstract
Purpose
The Nordic countries (27 M) all have comparable, publicly funded healthcare systems, and the management of sinonasal tumours is centralised to the 21 university hospitals. We sought to assess and compare the treatment practice of sinonasal tumours across the Nordic countries.

Methods
A web-based questionnaire was sent to all university hospital departments of otorhinolaryngology—head and neck surgery in the Nordic countries.

Results
Answers were obtained from all 21 Nordic university hospitals. The endoscopic approach was widely utilised by all, with most (62%) centres reporting 3–4 surgeons performing endoscopic sinonasal tumour surgery. Finland reported the lowest rates of centralisation among university hospitals despite having the highest number of 0.1–1 M catchment population hospitals. Most centres (88%) opted for the endoscopic approach in a patient case warranting medial maxillectomy. In a case of a Kadish C esthesioneuroblastoma, most (52%) of the centres preferred an endoscopic approach. Most centres (62%) reported favouring the endoscopic approach in a case describing a juvenile angiofibroma. Regarding a case describing a sinonasal undifferentiated carcinoma, consensus was tied (38% vs. 38%) between endoscopic resection followed by postoperative (chemo)radiotherapy (RT/CRT) and induction chemotherapy followed by RT/CRT or surgery followed by RT/CRT.

Conclusion
Endoscopic approach was widely utilised in the Nordic countries. The case-based replies showed differences in treatment practice, both internationally and nationally. The rate of centralisation among university hospitals remains relatively low, despite the rarity of these tumours.
Is triggering receptor expressed on myeloid cell 1 (TREM-1) protein a new marker of serious infectious complications in colorectal surgery?: case-matched pilot study
Authors: Pisarska-Adamczyk Magdalena , Rzepa Anna , Kapusta Maria , Zawadzka Karolina , Kuśnierz-Cabala Beata , Wysocki Michał , Małczak Piotr , Major Piotr , Zub-Pokrowiecka Anna , Wierdak Mateusz , Pędziwiatr Michał 
Published: September 2023

Abstract
Purpose
The purpose of the study was to evaluate the usefulness of the triggering receptor expressed on myeloid cell 1 (TREM-1) protein as a marker for serious infectious complications during laparoscopic colorectal surgery.

Methods
Sixty-four patients with colon or rectal cancer, who underwent an elective laparoscopic colorectal cancer surgery from November 2018 to February 2020, were included in the analysis. Blood samples of the TREM-1 protein testing were collected four times from each patient: before and on three following postoperative days (PODs). Patients were divided into two groups according to the presence of infectious complications. Subsequently, patients with infectious complications (group 1) were matched 1:1 with patients without complications (group 2). The case-matched analysis was done by selecting patients from the control group by age, ASA scale, cancer stage, and type of surgery.

Results
There was no significant difference in demographic and operative characteristics between the two groups. The median length of hospital stay was longer in group 1 than in group 2 (11 days vs. 5 days, p < 0.001). Preoperative measurements of TREM-1 protein did not differ between the two groups. There were no significant differences in the measurements on the first and third postoperative days. However, the median TREM-1 measurement was higher in group 1 on the second postoperative day (542 pg/ml vs. 399 pg/ml; p = 0.040). The difference was more apparent when only severe postoperative complications were considered. When compared to the group without any complications, the median TREM-1 level was significantly higher in the group with severe infection complications in POD 1, POD 2, and POD 3 (p < 0.05). The receiver operating characteristic (ROC) curve demonstrated that TREM-1 readings in POD 2 had a sensitivity of 83% and a specificity of 84% for the presence of severe infection complications at a value of 579.3 pg/ml (AUC 0.8, 95%CI 0.65–0.96).

Conclusion
TREM-1 measurements might become a helpful predictive marker in the early diagnosis of serious infectious complications in patients following laparoscopic colorectal surgery.
One-year outcome after open inguinal hernia repair with self-fixated mesh: a randomized controlled trial
Authors: Thölix Anna-Maria , Kössi Jyrki , Harju Jukka 
Published: September 2023

Abstract
Purpose
The aim of this study was to analyze pain after surgery with the use of self-fixated meshes, which are commonly used as an alternative for sutured mesh in open inguinal hernia repair.

Methods
This prospective randomized clinical trial was conducted from November 2018 to March 2021, with a follow-up duration of 12 months. Male patients, aged 18–85, and suitable for day case surgery, were included. The patients received the self-adhesive Adhesix™ mesh or the self-gripping Progrip™ mesh in open inguinal hernia surgery. The primary outcome was the number of additional follow-up visits due to post-operative pain. Secondary outcomes included intensity of pain, quality of life measures, and complications.

Results
Two hundred seventy patients were included in this trial, 132 with Adhesix™ (A group), and 138 with Progrip™ (P-group). All patients’ medical records were reviewed 12 months after surgery, and 207 patients (76.2%) completed 12-month follow-up. The number of patients needing additional follow-up visits 3–12 months after surgery were comparable (A group 3/3.0%, P-group 6/5.6%). The numeric rating scale was low at 12 months after surgery (at rest A 0.21, P 0.34, at exercise A 0.78, P 0.90). The incidence of chronic pain, that is moderate or severe pain during exercise, was 5 patients (5.2%) with Adhesix™ and 8 patients (7.4%) with Progrip™ (P = 0.333). Two hernia recurrences (1.0%) were established, one in each group.

Conclusion
At 1 year after hernia surgery, the use of self-gripping and self-adhesive meshes lead to successful pain reduction and quality of life improvement.
Trial registration.
ClinicalTrials.com NCT03734224.
Standardized Treatment and Diagnostic Approach to Reduce Disease burden in the early postoperative phase in children with congenital heart defects—STANDARD study: a pilot randomized controlled trial
Authors: Vogt Antonia , Meyer Sascha , Schäfers Hans-Joachim , Weise Julius Johannes , Wagenpfeil Stefan , Abdul-Khaliq Hashim , Poryo Martin 
Published: September 2023

AbstractTo explore the effect of a daily goal checklist on pediatric cardiac intensive care unit (PCICU) length of stay (LOS) after congenital heart surgery. This study is a prospective randomized single-center study. Group characteristics were as follows: STANDARD group: n = 30, 36.7% female, median age 0.9 years; control group: n = 33, 36.4% female, median age 1.1 years. Invasive ventilation time, STAT categories, mean vasoactive-inotropic score (VIS)24h, maximal (max.) VIS24h, mean VIS24–48h, max. VIS24–48h, VIS category, number of sedatives, analgesics, diuretics, number of deployed diagnostic modalities, morbidities, and mortality did not differ between both groups. Median PCICU LOS was 96.0 h (STANDARD group) versus 101.5 h (control group) (p = 0.63). In the overall cohort, univariate regression analysis identified age at surgery (b = −0.02), STAT category (b = 18.3), severity of CHD (b = 40.6), mean VIS24h (b = 3.5), max. VIS24h (b = 2.2), mean VIS24–48h (b = 6.5), and VIS category (b = 13.8) as significant parameters for prolonged PCICU LOS. In multivariate regression analysis, age at surgery (b = −0.2), severity of CHD (b = 44.0), and mean VIS24h (b = 6.7) were of significance. Within the STANDARD sub-group, univariate regression analysis determined STAT category (b = 32.3), severity of CHD (b = 70.0), mean VIS24h (b = 5.0), mean VIS24–48h (b = 5.9), number of defined goals (b = 2.6), number of achieved goals (b = 3.3), number of not achieved goals (b = 10.8), and number of unevaluated goals (b = 7.0) as significant parameters for prolonged PCICU LOS. Multivariate regression analysis identified the number of defined goals (b = 2.5) and the number of unevaluated goals (b = −3.0) to be significant parameters. Conclusion: The structured realization and recording of daily goals is of advantage in patients following pediatric cardiac surgery by reducing PCICU LOS.

What is known:• Communication errors are the most frequent reasons for adverse events in intensive care unit patients.• Improved communication can be achieved by discussion and documentation of the patients’ goals during daily rounds.

What is new:• In the overall cohort age at surgery, severity of congenital heart defect and mean vasoactive inotropic score within the first 24 hours had significant impact on pediatric cardiac intensive care unit (PCICU) length of stay (LOS).• In the intervention group, the number of defined goals and the number of unevaluated goals were significant parameters for prolonged PCICU LOS.
The Geometry of Random Tournaments
Authors: Kolesnik Brett , Sanchez Mario 
Published: September 2023

AbstractA tournament is an orientation of a graph. Each edge is a match, directed towards the winner. The score sequence lists the number of wins by each team. In this article, by interpreting score sequences geometrically, we generalize and extend classical theorems of Landau (Bull. Math. Biophys. 15, 143–148 (1953)) and Moon (Pac. J. Math. 13, 1343–1345 (1963)), via the theory of zonotopal tilings.
Swallowing Characteristics in Patients with Multiple System Atrophy Analyzed Using FEES Examination
Authors: Mozzanica Francesco , Pizzorni Nicole , Eplite Angelo , Ginocchio Daniela , Colombo Anna , Mora Gabriele , Ambrogi Federico , Warnecke Tobias , Schindler Antonio 
Published: September 2023

AbstractPatients with multiple system atrophy (MSA) frequently experience dysphagia but only few studies analyzed its characteristics. The aim of this study was to describe the swallowing characteristics in these patients using fiberoptic endoscopic evaluation of swallowing (FEES). In addition, the swallowing abilities in patients with predominantly cerebellar MSA (MSA-C) and predominantly parkinsonian MSA (MSA-P) were compared. Twenty-five patients with MSA (16 MSA-P and 9 MSA-C) were enrolled. Clinical data including age, sex, functional oral intake scale (FOIS) score, body mass index (BMI) and the results of the global disability-unified MSA rating scale (GD-UMSARS) were collected. Three different textures of food (liquid, semisolid, solid) were provided during FEES examination. The characteristics of dysphagia (safety, efficiency, phenotype) and laryngeal movement alterations were analyzed. Delayed pharyngeal phase (92%) and posterior oral incontinence (52%) were the phenotypes more frequently seen. Penetration was more frequent with Liquid (68%), while aspiration occurred only with Liquid (20%). Residues of ingested food were demonstrated both in the pyriform sinus and in the vallecula with all the consistencies. Vocal fold motion impairment was the laryngeal movement alteration most frequently encountered (56%). No significant differences between patients with MSA-P and MSA-C in the dysphagia characteristics and laryngeal movement alterations were found. Patients with MSA frequently experience swallowing impairment and altered laryngeal mobility. Dysphagia characteristics and laryngeal movements alterations seems to be similar in MSA-C and MSA-P.
Informational assessment of large scale self-similarity in nonlinear random field models
Authors: Angulo José M. , Ruiz-Medina María D. 
Published: September 2023

AbstractLarge-scale behavior of a wide class of spatial and spatiotemporal processes is characterized in terms of informational measures. Specifically, subordinated random fields defined by nonlinear transformations on the family of homogeneous and isotropic Lancaster–Sarmanov random fields are studied under long-range dependence (LRD) assumptions. In the spatial case, it is shown that Shannon mutual information between random field components for infinitely increasing distance, which can be properly interpreted as a measure of large scale structural complexity and diversity, has an asymptotic power law decay that depends on the underlying LRD parameter scaled by the subordinating function rank. Sensitivity with respect to distortion induced by the deformation parameter under the generalized form given by divergence-based Rényi mutual information is also analyzed. In the spatiotemporal framework, a spatial infinite-dimensional random field approach is adopted. The study of the large-scale asymptotic behavior is then extended under the proposal of a functional formulation of the Lancaster–Sarmanov random field class, as well as of divergence-based mutual information. Results are illustrated, in the context of geometrical analysis of sample paths, considering some scenarios based on Gaussian and Chi-Square subordinated spatial and spatiotemporal random fields.
Dezentrale Niederschlagswasserbewirtschaftung – Begriffe, Definitionen und Regelwerk
Authors: Neunteufel Bettina , König Albert , Muschalla Dirk 
Published: September 2023

ZusammenfassungKlimawandel und Urbanisierung verlangen nach Anpassungsstrategien, um auf die damit verbundenen Folgen wie pluviale Überflutungen, anhaltende Hitze- und Trockenperioden und Reduktion des pflanzenverfügbaren Wassers im Boden zu antworten. Maßnahmen der dezentralen Niederschlagswasserbewirtschaftung sind ein vielversprechender Baustein, um auf die zukünftigen Herausforderungen reagieren zu können. Dabei sind Maßnahmen der dezentralen Niederschlagswasserbewirtschaftung seit den 1980er-Jahren bekannt. Im internationalen Kontext haben sich unterschiedlichste Begriffe etabliert – von natürlicher und dezentraler Niederschlagswasserbewirtschaftung über Low Impact Development (LID), Water Sensitive Urban Design (WSUD), Sustainable Urban Drainage Systems (SUDS) bis zu Grün-Blauer Infrastruktur und Schwammstadt, die häufig auf ähnlichen Strategien und Technologien aufbauen. In Österreich ist für die Planung und Umsetzung von Maßnahmen der dezentralen Niederschlagswasserbewirtschaftung eine Vielzahl an Normen und Regelwerken zu berücksichtigen, die unterschiedlichste Anforderungen an die zu erstellenden Maßnahmen behandeln. Eine Zusammenfassung der maßgeblichen Regelwerke und eine systematische Kategorisierung und inhaltliche Zuordnung des vorhandenen Regelwerks erlaubt eine zielgerichtete Auswahl der zu berücksichtigenden Grundlagen. Aufgrund der fachlichen Breite der zu beachtenden Vorschriften und der Komplexität der Anforderungen an die Maßnahmen ist zukünftig eine fachübergreifende und interdisziplinäre Zusammenarbeit für Planung und Genehmigung unabdingbar.
All-solid-state chip utilizing molecular imprinted polymer for erythromycin detection in milk samples: Printed circuit board-based potentiometric system
Authors: Tantawy Mahmoud A. , Yehia Ali M. , Elbalkiny Heba T. 
Published: September 2023

AbstractDetection of erythromycin (ERY) residues in commercial milk samples is crucial for the safety assessment. Herein, a printed circuit board was patterned as a feasible miniaturized potentiometric sensor for ERY determination in dairy samples. The proposed chip design fits to a 3.5-mm female audio plug to facilitate the potential measurements of working electrode versus reference one in this all-solid-state system. The sensor utilizes molecular imprinted polymer (MIP) for the selective recognition of the studied drug in such challenging matrix. The electrode stability is achieved through the addition of poly (3,4-ethylenedioxythiophene) nano-dispersion on its surface. The proposed device detects down to 6.6 × 10−8 M ERY with a slope of 51 mV/decade in the 1 × 10−7–1 × 10−3 M range. The results display high accuracy (99.9% ± 2.6) with satisfactory relative standard deviation for repeatability (1.6%) and reproducibility (5.0%). The effect of common antibiotic classes, namely, amphenicols, beta-lactams, fluoroquinolones, sulfonamides, and tetracyclines, can be neglected as evidenced by their calculated binding capacities towards the proposed MIP. The calculated selectivity coefficients also show a good electrode performance in the presence of naturally present inorganic ions allowing its application to different milk samples.
Graphical abstract
Supportive care and antiviral treatments in primary herpetic gingivostomatitis: a systematic review
Authors: Coppola Noemi , Cantile Tiziana , Adamo Daniela , Canfora Federica , Baldares Stefania , Riccitiello Francesco , Musella Gennaro , Mignogna Michele Davide D. , Leuci Stefania 
Published: September 2023

Abstract
Objectives
Herpes simplex virus 1 (HSV-1) is the main pathogen responsible for herpes infections. In 13–30% of the cases, primary HSV-1 leads to the primary herpetic gingivostomatitis (PHGS), often a self-limiting infection; however, it can limit the ability to drink/eat with, sometimes, the need for hospitalization. Multiple therapeutic methods have been proposed. This systematic review aims to collect and critically appraise the available evidence about the clinical management of PHGS.

Materials and methods
Literature search including three databases (PubMed, Scopus, Embase), study design, and data analysis were performed following PRISMA guidelines, according to the PICO tool (PROSPERO n° CRD42023391386). Risk of bias was assessed with RoB 2 and ROBINS-I.

Results
Five studies on a total of 364 patients (average age: 7.6 years) were identified. The treatment regimens were summarized in acyclovir; acyclovir + honey; fluids and analgesic; maalox + diphenhydramine; lidocaine; chlorhexidine (CHX); CHX + ialuronic acid; CHX + Mucosyte®; antimicrobial photodynamic therapy (aPDT); topical antiviral; topical antiviral + aPDT; and others.

Conclusions
Although PHGS is a disease with a high worldwide prevalence, the lack of consensus about therapeutic management indicates gaps in existing evidence. Most of the proposed treatment consists in symptomatic drugs with empiric regimens which are ineffective for the viral replication. The main limit to realize randomized clinical trial is due to the rapid onset and remission of the disease. In fact, the diagnostic delay, estimated in 72 h, decreases the effectiveness of any antiviral drugs.

Clinical relevance
Out of the five studies included in this systematic review, only one was able to provide some weak evidence that ACV is an effective treatment, improving healing of oral lesions and reducing duration of symptoms.
Digital Libraries, Epigraphy and Paleography: Bring Records from the Distant Past to the Present: Part II
Authors: Griffin Stephen M. 
Published: September 2023

AbstractThe two volumes of this Special Issue explore the intersections of digital libraries, epigraphy and paleography. Digital libraries research, practices and infrastructures have transformed the study of ancient inscriptions by providing organizing principles for collections building, defining interoperability requirements and developing innovative user tools and services. Yet linking collections and their contents to support advanced scholarly work in epigraphy and paleography tests the limits of current digital libraries applications. This is due, in part, to the magnitude and heterogeneity of works created over a time period of more than five millennia. The remarkable diversity ranges from the types of artifacts to the methods used in their production to the singularity of individual marks contained within them. Conversion of analogue collections to digital repositories is well underway—but most often not in a way that meets the basic requirements needed to support scholarly workflows. This is beginning to change as collections and content are being described more fully with rich annotations and metadata conforming to established standards. New use of imaging technologies and computational approaches are remediating damaged works and revealing text that has, over time, become illegible or hidden. Transcription of handwritten text to machine-readable form is still primarily a manual process, but research into automated transcription is moving forward. Progress in digital libraries research and practices coupled with collections development of ancient writtten works suggests that epigraphy and paleography will gain new prominence in the Academy.
A review and meta-analysis of stem cell therapies in stroke patients: effectiveness and safety evaluation
Authors: Hovhannisyan L. , Khachatryan S. , Khamperyan A. , Matinyan S. 
Published: September 2023

Abstract
Purpose
Stem cells have been extensively used during the last decade to improve clinical outcomes after stroke. The dramatic increase in trials in this field has led us to perform a systematic review and meta-analysis to understand the safety, effectiveness, and relative limitations of this type of intervention.

Method
This review summarizes the current evidence pooled from PubMed (Medline), EMBASE, EBSCOhost, http://clinicaltrials.gov, Scopus (Elsevier), Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science (Science Citation Index Expanded) databases for the use of stem cell therapies in stroke patients without combinations with other treatment modalities. The National Institutes of Health Stroke, modified Rankin Scales, and Barthel Index scores after external stem cell administration have been evaluated on the 3rd, 6th, and 12th months after treatment. The random effect analysis was performed using the Review Manager 5.4.1. The characteristics of stem cell sources and their adverse effects have been discussed as well.

Findings
Although reasonably safe, the effectiveness evidence fluctuated to a large extent due to the heterogeneity of the clinical trials and the absence of a systematic approach. The stem cell sources and the administration window were not strongly associated with clinical outcomes.

Conclusion
Further studies should be conducted to understand the deep discrepancy between preclinical and clinical trials and to execute phase 3 clinical trials with robust control of study characteristics and outcomes.