bluuebunny/crossref_metadata_2025_split huggingface dataset:
Saudi teachers' perspectives on flipped learning: Are they ready and willing?
Authors: Rajeh Hamzah S. 
Published: September 2023

PurposeIncorporating flipped learning (FL) into teaching English as a foreign language may improve student learning outcomes. This study gathered information on Saudi EFL teachers' readiness and willingness to apply FL. So, it aims to describe Saudi EFL teachers' readiness and willingness to apply FL in language classrooms and to find suitable guidelines for Saudi EFL professional development (PD) designers to follow.Design/methodology/approachThis descriptive study involved 153 male and female Saudi EFL teachers as participants, investigating the perspectives and perceptions of these teachers within the context of foreign language teaching in Saudi Arabia. Surveys in Qualtrics were employed as the primary data collection tool for the study.FindingsResults showed that teachers' self-efficacy of their current teaching was high. Most participants had positive attitudes and abilities related to FL, although they also identified potential challenges related to its engagement and assessment. Teachers expressed a strong willingness to participate in PD in this area, with a preference for online videos and group workshops.Originality/valueThe study emphasizes the importance of PD for Saudi EFL teachers. In addition, it offers guidelines for planning effective PD.
That Monster Over There: Silvia Kolbowski, Trump, and Allegory
Authors: Knapp Ivan 
Published: September 2023

Abstract
This essay considers the ways in which Silvia Kolbowski's 2018 video That Monster: An Allegory addresses the psychical and political basis of Donald J. Trump's appeal in the 2016 US election. The video is crafted out of a collection of fragments from James Whale's 1935 The Bride of Frankenstein, which Kolbowski plays first with a score by Philip Glass and then in silence. This article asks how such a format might illuminate resonances between certain psychoanalytic concepts and the postmodernist discourse of allegory as exemplified in the work of Paul de Man and Craig Owens. I argue that these theoretical frameworks help us to retain an open reading of Kolbowski's allegory which shifts an interpretive focus from questions of identity to problems of repetition, refusal, and erasure.
Insular volumetry in severe alcohol use disorder and Korsakoff's syndrome through an anatomical parcellation: Let us go back to basics
Authors: Billaux Pauline , Maurage Pierre , Cabé Nicolas , Laniepce Alice , Segobin Shailendra , Pitel Anne‐Lise 
Published: September 2023

AbstractFunctional neuroimaging has demonstrated the key role played by the insula in severe alcohol use disorder (sAUD), notably through its involvement in craving and body signals processing. However, the anatomical counterpart of these functional modifications in sAUD patients with and without neurological complications remains largely unexplored, especially using state‐of‐the‐art parcellation tools. We thus compared the grey matter volume of insular subregions (form anterior to posterior: anterior inferior cortex, anterior short gyrus, middle short gyrus, posterior short gyrus, anterior long gyrus, posterior long gyrus) in 50 recently detoxified patients with sAUD, 19 patients with Korsakoff's syndrome (KS) and 36 healthy controls (HC). We used a mixed linear model analysis to explore group differences in the six subregions grey matter volume and lateralization differences. Insular macrostructure was globally affected to the same extent in sAUD with and without KS, indicating that these brain abnormalities may be related to alcohol consumption per se, rather than to the presence of alcohol‐related neurological complications. Insular atrophy showed a right‐sided lateralization effect and was especially marked in the posterior insula, a region associated with visceral information processing and the embodiment effect of a substance, from which craving arises. Anatomical damages might thus underlie the previously reported altered insular activations and their behavioural counterparts.
Review of the caroticotympanic nerves: Anatomy, function and pathology
Authors: Albuck Aaron L. , Techabunyart Daniel B. , Cardona Juan J. , Chaiyamoon Arada , Tsang Preston , Iwanaga Joe , Dumont Aaron S. , Tubbs R. Shane 
Published: September 2023

AbstractThe caroticotympanic nerves provide postganglionic sympathetic fibres to the tympanic plexus. However, there are scant reports in the literature detailing with these nerves in great depth. As the caroticotympanic plexus lies near the often‐operated tympanic nerve, it is important for the surgeon to understand the anatomy, pathology and surgical implications of it. Here, we present a review of the available literature regarding the caroticotympanic nerves.
Preoperative chronic kidney disease and complications after pancreatoduodenectomy: a retrospective cohort study
Authors: Swartling Oskar , Evans Marie , Larsson Patrik , Perri Giampaolo , Yarbakht Danial , Al‐Kamil Hussein , Gilg Stefan , Holmberg Marcus , Sparrelid Ernesto , Ghorbani Poya 
Published: September 2023

AbstractBackgroundChronic kidney disease is a prevalent condition in surgical patients. Possible associations with increased postoperative morbidity and mortality have not been clearly demonstrated in patients undergoing pancreatoduodenectomy. The aim of this study was to assess the risk of postoperative complications in patients with reduced kidney function undergoing pancreatoduodenectomy.MethodsAll patients undergoing pancreatoduodenectomy at Karolinska University Hospital between 2008 and 2019 were retrospectively included. The variable of interest was chronic kidney disease, based on preoperative estimated glomerular filtration rate measurements. Unadjusted and adjusted logistic regression analyses were performed for standardized postoperative complications.ResultsA total of 971 patients were included in the study, of whom 92 (10%) had an estimated glomerular filtration rate < 60 mL/min/1.73m2, equivalent to chronic kidney disease Stage 3a or worse. Patients with chronic kidney disease had a higher odds of longer hospital stay (adjusted odds ratio 1.58, 95% confidence interval 1.00–2.50) and postoperative weight increase (adjusted odds ratio 2.02, 1.14–3.56). A 10 unit increase of preoperative estimated glomerular filtration rate was associated to lower odds of intensive care unit admission (adjusted odds ratio 0.81, 0.69–0.95), delayed gastric emptying (adjusted odds ratio 0.90, 0.81–0.99), and post‐operative pancreatic fistula (adjusted odds ratio 0.83, 0.74–0.94).ConclusionPatients undergoing pancreatoduodenectomy with decreased preoperative kidney function are more likely to experience major postoperative complications, and also postoperative weight increase. Preoperative kidney function assessment is important in risk stratification before pancreatoduodenectomies.
Letter: future studies of high‐dose thiamine should consider whether its effects on fatigue are related to the inhibition of carbonic anhydrase isoenzymes. Authors' reply
Authors: Bager Palle , Hvas Christian , Rud Charlotte , Dahlerup Jens 
Published: September 2023

LINKED CONTENTThis article is linked to Bager et al and Lubell papers. To view these articles, visit https://doi.org/10.1111/apt.16166 and https://doi.org/10.1111/apt.16275
Review article: comprehensive analysis of cirrhotic cardiomyopathy
Authors: Chahal Daljeet , Liu Hongqun , Shamatutu Chris , Sidhu Hasrit , Lee Samuel S. , Marquez Vladimir 
Published: September 2023

SummaryBackgroundPatients with cirrhosis are at risk of developing cirrhotic cardiomyopathy. This syndrome is unique to cirrhosis and is generally defined as subnormal cardiac function in the absence of prior heart disease. There is no systematic or comprehensive review of cirrhotic cardiomyopathy to date.AimsTo comprehensively review the literature on the definition, pathogenic mechanisms, diagnostic criteria, prevalence, management and influence on liver transplantation including reversibility of cirrhotic cardiomyopathy.MethodsElectronic searches of the EMBASE, MEDLINE, EBM Reviews—Cochrane Central Register of Controlled Trials, EBM Reviews—Cochrane Database of Systematic Reviews and Google Scholar databases were conducted. MeSH terms focused on cirrhosis, cardiomyopathy, medication classes and epidemiology. Literature up to August 2020 was reviewed.ResultsNew diagnostic criteria for the definition of cirrhotic cardiomyopathy have recently been published, consisting of systolic and diastolic dysfunction parameters as assessed by echocardiographic methods. The roles of electrocardiographic disturbances and biomarkers in the definition criteria remain unclear. Pathogenic mechanisms underlying cirrhotic cardiomyopathy are likely related to the inflammatory phenotype of cirrhosis. Prevalence rates of 26%‐81% in cirrhotic patients are reported. Several medical therapies have been proposed, but none with clear evidence of efficacy. The presence of cirrhotic cardiomyopathy complicates the liver transplantation process with a higher risk of adverse cardiovascular events post‐transplant. Complete reversibility of the syndrome after transplantation remains controversial but most studies suggest that it does not occur at least within the first post‐operative year.ConclusionsCirrhotic cardiomyopathy is a clinically relevant syndrome that affects morbidity and mortality in patients with cirrhosis.
Review article: investigation and management of internal fistulae in Crohn’s disease
Authors: Tjandra Douglas , Garg Mayur , Behrenbruch Cori , McCormick Jacob , Simkin Paul , Prentice Ralley , Trinh Andrew , Al‐Ani Aysha , Vaughan Rose , Macrae Finlay , Christensen Britt 
Published: September 2023

SummaryBackgroundCrohn’s disease is an inflammatory, penetrating intestinal disease associated with fistula formation. Fistulae in Crohn’s disease can be classified into external and internal fistulae. Internal fistulae form between the gastrointestinal tract and another internal organ and include enteroenteric, enterocolic, enterovesical and rectovaginal fistulae. They are associated with significant morbidity and a decreased quality of life.AimTo review the classification, diagnosis, medical and surgical management of internal fistulae in Crohn’s disease, and propose a treatment algorithm.MethodsA literature review on internal fistulae in Crohn’s disease in the adult population was undertaken, synthesised and summarised.ResultsInternal fistulae occur in up to 15% of patients with Crohn’s disease. Multi‐modal assessment including a combination of endoscopy and cross‐sectional imaging, usually magnetic resonance, is required to diagnose fistulae and determine extent of disease. Determining optimal treatment strategies for these complex fistulae remains a challenge due to limited and generally low‐quality data. Most studies to date have focussed on luminal disease, with (usually post hoc) outcomes more often reported for external fistulae, particularly perianal fistulae, than internal fistulae. Anti‐tumour necrosis factor therapies have emerged as the mainstay of medical therapy, with particularly promising data for enterovesical fistulae, but many patients will still require surgical intervention. The indications and optimal timing of surgery vs medical therapy remains uncertain; thus multi‐disciplinary input when making such decisions is important.ConclusionsInternal fistulae result in significantly increased morbidity in Crohn’s disease, and further studies to determine optimal multi‐modality management strategies incorporating medical and surgical therapy are required.
Letter: increased incidence of tissue transglutaminase antibody in Israel—is it always related to coeliac disease? Authors' reply
Authors: Ben Tov Amir , Chodick Gabriel , Cohen Shlomi , Lechtman Niva , Shamir Raanan 
Published: September 2023

LINKED CONTENTThis article is linked to Lechtman et al and Beenet and Tonesi papers. To view these articles, visit https://doi.org/10.1111/apt.16282 and https://doi.org/10.1111/apt.16320
Velusetrag accelerates gastric emptying in subjects with gastroparesis: a multicentre, double‐blind, randomised, placebo‐controlled, phase 2 study
Authors: Kuo Braden , Barnes Chris N. , Nguyen Deanna D. , Shaywitz David , Grimaldi Maria , Renzulli Cecilia , Canafax Daniel , Parkman Henry P. 
Published: September 2023

SummaryBackgroundGastroparesis is a serious gastrointestinal (GI) condition characterised by delayed gastric emptying (GE). Velusetrag—a potent, selective, pan‐gastrointestinal 5‐hydroxytryptamine type 4 receptor agonist—is under investigation for treatment of GI motility disorders including gastroparesis.AimsTo assess the efficacy and safety of velusetrag for accelerating GE in subjects with diabetic or idiopathic gastroparesis.MethodsIn this multicentre, randomised, double‐blind, placebo‐controlled, three‐period fixed‐sequence crossover phase 2 study, subjects with diabetic or idiopathic gastroparesis received oral velusetrag (5, 15 or 30 mg) or placebo once daily for 7 days each. The primary outcome was proportion of subjects achieving ≥20% reduction in GE half‐time (GE t1/2) from each treatment period baseline on day 7. Absolute and percent changes from baseline GE t1/2 were also assessed. GE was measured using a [13C]‐octanoate breath test. Safety was evaluated from treatment‐emergent adverse events (TEAEs).ResultsThirty‐four subjects (67.6% female; mean age, 46.3 years; 52.9% with diabetic gastroparesis) were included. Treatment with velusetrag 30 mg significantly increased the proportion of subjects with ≥20% reduction from baseline GE t1/2 compared with placebo (52% vs 5%, P = 0.002), and GE t1/2 was numerically reduced following all three doses of velusetrag relative to placebo treatment. Efficacy was similar between subjects with diabetic and idiopathic gastroparesis. Velusetrag treatment was generally well tolerated; most TEAEs were mild and related to GI transit acceleration.ConclusionsVelusetrag accelerates GE in subjects with diabetic or idiopathic gastroparesis and is generally well tolerated in this population (Clinicaltrials.gov NCT01718938).
Determinants of IBD‐related disability: a cross‐sectional survey from the GETAID
Authors: Tannoury Jenny , Nachury Maria , Martins Carole , Serrero Melanie , Filippi Jerome , Roblin Xavier , Bourrier Anne , Bouguen Guillaume , Franchimont Denis , Savoye Guillaume , Buisson Anthony , Louis Edouard , Nancey Stephane , Abitbol Vered , Reimund Jean‐Marie , DeWitt Olivier , Vuitton Lucine , Mathieu Nicolas , Peyrin‐Biroulet Laurent , Gilletta Cyrielle , Allez Matthieu , Viennot Stephanie , Trang‐Poisson Caroline , Laharie David , Amiot Aurelien ,   the GETAID‐Patient Experience Study Group
Published: September 2023

SummaryBackgroundThe burden of inflammatory bowel disease (IBD) is rising worldwide. The goal of IBD treatment is to achieve clinical and endoscopic remission but also prevent disability.AimsTo identify the predictive factors of disability in a large population of patients with IBD.Patients and methodsWe conducted a cross‐sectional survey in 42 tertiary centres in France and Belgium. A self‐administered questionnaire was designed to explore patients and their IBD characteristics. IBD‐disk is a validated tool to measure disability in patients with IBD. The IBD‐disk score was then calculated for each patient. Based on a previous study, an overall IBD‐disk score ≥40 was associated with moderate‐to‐severe disability.ResultsAmong the 2011 patients, 1700 were analysed, including 746 (44%) in self‐reported clinical remission and 752 (44.2%) declaring clinical activity. The patient global assessment of global remission was missing in 200 (11.8%) of 1700 patients. Moderate‐to‐severe disability was significantly increased in patients with BMI >25 kg/m2 (OR = 1.66; 95% CI [1.29‐2.14]), in those having perception of need for a psychotherapist (OR = 2.24; 95% CI [1.79‐3.05]) and social worker (OR = 1.54; 95% CI [1.08‐2.21]). Conversely, male gender (OR = 0.83; 95% CI [0.69‐0.99]), ulcerative colitis (OR = 0.69; 95% CI [0.53‐0.92]), self‐reported clinical remission (OR = 0.59; 95% CI [0.46‐0.77]) and employed or student occupational status (OR = 0.69; 95% CI [0.52‐0.92]) were inversely correlated with disability. Overall, 257 (34.5%) patients who declared being in clinical remission had disability.ConclusionDeterminants of IBD‐related disability include IBD‐related factors but also psychological and social factors. This highlights the importance of a multidisciplinary team in the management of patients with IBD.
Trends in paediatric inflammatory bowel disease‐attributable direct costs: a population‐based analysis
Authors: El‐Matary Wael , Nugent Zoann , Witt Julia , Bernstein Charles N. 
Published: September 2023

SummaryBackgroundIn addition to its morbidities, inflammatory bowel disease (IBD) has a major financial burden on patients and healthcare systems. However, there is a paucity of evidence on IBD‐attributable costs in children.AimsTo determine the trends of IBD‐attributable direct costs over time using a population‐based analysis.MethodsData were extracted from Manitoba Health Provider Claims and other population registry datasets from 1995 to 2017. Children with IBD were matched by age, sex and location with children without IBD. IBD‐attributable direct costs were calculated using utilization counts from the administrative data and cost estimates from different sources. Inpatient hospitalisation and outpatient procedure costs were estimated using the resource intensity weight (RIW) that is attached to each record in the data. Costs were expressed in Canadian dollars.ResultsWe included 733 (428 with Crohn's disease) prevalent cases who were diagnosed with IBD before the age of 18 years and were followed for 2450 person‐years. A matched control group of 6763 persons who were followed for 21 558 person‐years was included. The median annual costs of physician services billed per patient increased from $381 (IQR 215‐1064) in 1995 to $936 (IQR 579‐1932) in 2017 (P < 0.001). The annual medication costs per patient increased from a median of $270 in 1995 to $7944 in 2017 (P < 0.0001). The median annual direct cost per patient was $1810 in 2004 as compared to $14 791 (P < 0.0001) in 2017.ConclusionsOver two decades, there was a significant increase in the paediatric IBD‐attributable direct costs mainly driven by medication costs.
One‐piece versus two‐piece zirconia abutment supported single implant crown in the esthetic region: 3‐Year results from a split‐mouth randomized controlled clinical trial
Authors: Lv Xiaolei , Pu Yiping , Zhang Xiaomeng , Jiang Xue , Zhang Xiao , Shi Junyu , Lai Hongchang 
Published: September 2023

AbstractObjectivesTo compare the clinical, radiographic, and immunological outcomes between one‐piece versus two‐piece zirconia abutments supported single implant crowns in the esthetic region.Materials and MethodsThe study followed a split‐mouth, double‐blind, and randomized controlled clinical design for a duration of 3 years. Twenty‐two eligible patients with 44 implants were randomly assigned to two groups: Group 1 (one‐piece zirconia abutment with zirconia base, n = 22) and Group 2 (two‐piece zirconia abutment with titanium base, n = 22). The primary outcome was the technical complication rate. Additionally, survival rates, cytokines concentrations in peri‐implant crevicular fluid (PICF), peri‐implant conditions, marginal bone loss, and pink/white esthetics score (PES/WES) were assessed as secondary outcomes.ResultsTwelve of 22 patients attended the 1‐year follow‐up (due to the COVID pandemic), and 19 patients attended the 3‐year examination. Two abutments in Group 1 were fractured after 10 and 12 months in function. Additionally, one screw loosening occurred in Group 1 at 1‐year follow‐up. The 3‐year technical complication rate was significantly higher in Group 1 than that in Group 2 (15.79% vs. 0%, p < .001). The 3‐year implant survival rate was 100% in both groups. The concentration of IFN‐γ in PICF was significantly upregulated in Group 2 (p = .018). Furthermore, the IL‐6 concentration was positively correlated with BOP% (p = .020).ConclusionsTwo‐piece zirconia abutments exhibited superior technical performance compared to one‐piece designs during a 3‐year follow‐up in the anterior region. However, further long‐term research is necessary to verify the immunological stability of two‐piece zirconia abutments.
Cigarette smoke uptake by different woven fabrics: Analysis of mechanical and colour properties
Authors: Kayar Mahmut , Boztoprak Yalçin , Nallbani Belma Gjergjizi 
Published: September 2023

AbstractAlthough the impact of smoking tobacco on human health is well understood, less is known about the effects of tobacco smoke on cotton, viscose and polyamide fabrics. In this study, tobacco smoke was applied to fabric samples to investigate the effects of tobacco smoke on their mechanical and colour properties. For this purpose, tobacco smoke was pumped into a mechanism consisting of a glass box, in which cotton, viscose and polyamide fabrics were placed in a suspended position. The fabric samples were treated with tobacco smoke for 1 or 2 months. The samples were evaluated in terms of tensile and tear strength, elongation at break, as well as pilling and abrasion resistance values. A colour measurement test was used to investigate the withering effect of tobacco smoke, and Fourier Transfer–Infrared analysis was performed to examine the chemical changes. The tensile strength values in the warp direction were 419.34, 404.62 and 421.78 N without treatment and after 1 and 2 months of tobacco smoke treatment, respectively, for the cotton woven fabric. Furthermore, for woven cotton fabric, the L* value decreased from 93.8 to 78.7 after being treated with tobacco smoke for 2 months. As a result of this study, it was determined that tobacco smoke has no effect on the tensile strength properties of fabrics, causes changes to pilling and abrasion resistance values, and adversely affects the colour properties of fabrics.
Atrial fibrillation as a risk factor for exercise‐induced pulmonary haemorrhage following a standardised exercise test
Authors: Hansen Sanni , Otten Nina D. , Nissen Sarah D. , Carstensen Helena , Hopster‐Iversen Charlotte , Fjeldborg Julie , Staun Sophie H. , Fenner Merle , Hesselkilde Eva M. , Buhl Rikke 
Published: September 2023

AbstractBackgroundAtrial fibrillation (AF) has been proposed as a risk factor for exercise‐induced pulmonary haemorrhage (EIPH) due to increased pressure in the left atrium.ObjectiveTo evaluate if AF was associated with EIPH following a standardised exercise test (SET) to fatigue.Study designTwo‐arm controlled experiment.MethodsTen untrained Standardbred mares mean (standard deviation [SD]) age 6 (2) years performed a SET on the treadmill in sinus rhythm (SR) (SET1) and 25–44 days after induction of self‐sustained AF (SET2). AF was induced by tachypacing using a pacing device. Endoscopy, including tracheal wash and bronchoalveolar lavage (BAL), was performed 48–72 h before and 24 h after the two SETs. In addition, endoscopic grading of tracheal blood was performed 2 h after each SET.ResultsAfter SET1, none of the horses showed blood in the trachea, and two horses showed erythrophagocytosis. Following SET2, two horses had grade 1 blood in the trachea and free erythrocytes and erythrophagocytosis in the BAL, while another two horses had erythrophagocytosis in the BAL. In SET2, the overall performance on the treadmill was decreased with a lower maximum velocity (SET1 10.3 ± 0.8 m/s vs. SET2 8.9 ± 0.9 m/s, p = 0.004), a higher heart rate (284 ± 21 vs. 221 ± 18 bpm, p = 0.003) and more abnormal QRS complexes (p < 0.001) compared with SET1.ConclusionsTwo horses showed signs of EIPH, resulting in visible blood in the trachea, when exercising in AF compared with SR. However, a possible link between EIPH, pulmonary pressure and AF needs to be further elucidated.