bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventive effect of a traditional Japanese Kampo medicine, shakuyakukanzoto, against neurotoxicity of FOLFOX plus bevacizumab used for metastatic colorectal cancer management: A single‐arm phase II study
Authors: Takagi Hiroaki , Kajiura Shinya , Hosokawa Ayumu , Horikawa Naoki , Terada Itsuro , Hata Taishi , Kobayashi Yuka , Tsukioka Yuji , Yabushita Kazuhisa , Matsuo Takashi , Yoshita Hiroki , Ueda Akira , Ogawa Kohei , Ando Takayuki , Hayashi Ryuji , Yasuda Ichiro 
Published: September 2023

AbstractAim5‐Fluorouracil/folinic acid and oxaliplatin plus bevacizumab (FOLFOX + BV) is a standard chemotherapy regimen for metastatic colorectal cancer (mCRC). This study was aimed at evaluating the preventive effects of shakuyakukanzoto against oxaliplatin‐induced neurotoxicity associated with FOLFOX + BV administration.MethodsIn this single‐arm, open‐label, phase II clinical trial, we enrolled patients with previously untreated, histologically confirmed mCRC from six hospitals in Japan who were aged 20 years and older and had an Eastern Cooperative Oncology Group performance status of 0–1. The patients received shakuyakukanzoto 2.5 g thrice daily, orally, until disease progression and/or unacceptable toxicity was noted. The primary endpoint was the incidence of neurotoxicity following oxaliplatin administration at a dose of 500 mg/m2. Neurotoxicity was evaluated according to the Neurotoxicity Criteria of Debiopharm (DEB‐NTC). The trial was registered in the UMIN Clinical Trials Registry of Japan (UMIN000001853).ResultsForty‐one non‐pretreated mCRC patients were included between April 2009 and September 2013. At an oxaliplatin dose of 500 mg/m2, neurotoxicity of DEB‐NTC grade 1–2 developed in 25.0% of patients; no patient had DEB‐NTC grade 3 neurotoxicity. The most common grade 3/4 adverse events were neutropenia (34.1%), hypertension (24.4%), and fatigue (9.8%). The response rate of the 38 patients with measurable lesions was 55.2%. The median progression‐free and overall survival was 14.9 and 35.2 months respectively.ConclusionShakuyakukanzoto substantially reduced oxaliplatin‐induced neurotoxicity without negatively affecting tumor response or survival in FOLFOX + BV‐treated patients with CRC.
International Standards of Internal Control Relevant to the Application of PFM/IC
Authors: Hepworth Noel 
Published: September 2023

AbstractA feature of PFM/I reforms has been the adoption of international standards and the relevant international standards have been those developed by a US body called the Committee of Sponsoring Organisations (COSO). There are five standards. These standards are described in this chapter. However, in the opinion of author the adoption by most countries has been flawed because they have largely been treated as financial and budgetary control standards with no regard to the managerial implications of those standards. Application has started from an internal audit perspective when it would have been much better to have started from a management perspective. Implicit in the writing of those standards is a set of managerial assumptions and these assumptions have been ignored. Indeed it would be better to describe these standards as ‘managerial disciplines’. Also in applying international standards regard should be had to local cultural and historic conditions but this rarely seems to happen and almost by definition the adoption of international standards is regarded as ‘a good thing’. For example, applying the standards when the responsibility for operational management lies with a political official whose experience of operational management may be limited and who may only be in post for a short period is inappropriate. It does not reflect the operational circumstances applying in those organisations for which the standards have been developed namely large international trading companies.
The Responsibilities of the Minister of Finance, the State Secretary, and the Ministry in the Development of a PFM/IC Policy
Authors: Hepworth Noel 
Published: September 2023

AbstractThe ministry of finance has a key role in both the acceptance and the implementation of this reform. By 'ministry of finance' is meant the minister personally, the most senior appointed official such as the state secretary and the heads of key ministry of finance departments such as the budget department and the accounting or treasury department. Their support for the reform is essential. Central to the reform is a change in responsibilities for budgetary and financial control from a centralised external control based upon the ministry of finance to an internal control with the primary responsibility falling on individual public organisations. Success with this element of the reform depends upon many factors and not least the quality of individual public organisation management and that involves the leadership exercised by those managers and their training. A key element in this is ‘financial awareness’. The significance of the role of the ministry of finance extends to ensuring that the reform is properly implemented and this imposes a responsibility upon the top official in that ministry to personally lead the reform and to ensure that the equivalent top officials in other public organisations are equally committed and involved. This chapter explains the responsibilities of the different key ministry of finance officials and the risks that they should be aware of. This includes the role of the minister and the top appointed officials.
Fostering Responsiveness in Early Mathematics Learning
Authors: Beck Melanie , Vogler Anna-Marietha 
Published: September 2023

AbstractFrom a co-constructive perspective, interactions between adults and children are key variables for learning processes, especially in early childhood. The following paper focuses on such interactions that emerge in ‘mathematical situations of play and exploration’ in German kindergartens. These mathematical situations are conducted by adults who are specially trained in so-called ‘design patterns of mathematical situations’. The paper examines within this context the extent to which interactions carried out by such trained adults are characterized by a high degree of adaptive moves by the adult and a high degree of interactional responsiveness. For this purpose, the construct of responsiveness is presented and two scenes from a German kindergarten are analyzed. Finally, the empirical findings of the paper draw initial conclusions for a professional development concept for preschool teachers based on the determined ‘patterns’.
The Appearance of Playfulness in Swedish Preschool Class Mathematics Teaching
Authors: Björklund Camilla , Elofsson Jessica 
Published: September 2023

AbstractThis paper reports on an investigation of how playfulness and mathematics as a content for learning appear in mathematics teaching about numbers with six-year-olds in Sweden. A total of 81 observations of teaching activities are qualitatively analyzed, resulting in three appearances: mathematical content as the primary task; exploring the mathematical content in a relevant context; and the mathematical task situated in a playful context. These entail different opportunities for the six-year-olds to experience meaningful mathematics. The paper discusses the significance of playfulness as a feature of mathematics teaching in early education, and particularly brings to the fore nuances in different ways of making playfulness an asset in teaching.
I Can Do It on My Own?! Evaluation of Types of Implementation of Digital Game-Based Learning in Early Mathematics Education
Authors: Birklein Laura , Steinweg Anna Susanne 
Published: September 2023

AbstractThis contribution gives exemplary insight in some results of the project EfEKt. The study evaluates different aspects of the implementation of the tablet app MaiKe, which has been developed to support mathematical competencies of children aged 4–6. The use of digital media in early childhood education is often discussed very critically in Germany. The research design, therefore, compares differences between free and supervised settings of use implementation in two designs for intervention groups. Above all, EfEKt investigates the effect of the app use on the development of children’s mathematical competencies. Our results show that a free play setting does not lead to an extensive use of digital media. The pre- and post-test results show statistically relevant positive effects of the MaiKe app use on the development of mathematical competencies in both intervention groups compared to a control group. Qualitative analyses indicate that the participating children use more sophisticated mathematical strategies over the course of the intervention period.
Freeze-in dark matter via lepton portal: Hubble tension and stellar cooling
Authors: Xu Zixuan , Xu Shuai , Zhang Ruopeng , Zheng Sibo 
Published: September 2023

Abstract
We propose a new freeze-in dark matter candidate which feebly couples to the standard model charged leptons. The feeble interactions allow it (i) to freeze-in from the Standard Model thermal bath with its relic density being either a fraction or the entirety of the observed dark matter density and (ii) to radiatively decay to two photons in the dark matter mass ranges of order keV scale with lifetime larger than the age of Universe. These features make this model a realistic realization of dark matter with late-time decay to reduce Hubble tension. We show the best-fit value of H0 = 68.31(69.34) km s−1Mpc−1 in light of Planck 2018+BAO(+LSS)+Pantheon data sets. We then use stellar cooling data to place constraints on the parameter space favored by the Hubble tension. While the universal coupling scenario is excluded, the hierarchical coupling scenario can be tested by future observations of white dwarfs after a careful look into photon inverse decay, Primakoff and Bremsstrahlung emission of the dark matter in various stellar systems. The viable parameter space may be linked to anomalies in future X-ray telescopes.
The 3-wave resonant interaction model: spectra and instabilities of plane waves
Authors: Romano Marzia , Lombardo Sara , Sommacal Matteo 
Published: September 2023

AbstractThe three wave resonant interaction model (3WRI) is a non-dispersive system with quadratic coupling between the components that finds application in many areas, including nonlinear optics, fluids and plasma physics. Using its integrability, and in particular its Lax Pair representation, we carry out the linear stability analysis of the plane wave solutions interacting under resonant conditions when they are perturbed via localised perturbations. A topological classification of the so-called stability spectra is provided with respect to the physical parameters appearing both in the system itself and in its plane wave solution. Alongside the stability spectra, we compute the corresponding gain function, from which we deduce that this system is linearly unstable for any generic choice of the physical parameters. In addition to stability spectra of the same kind observed in the system of two coupled nonlinear Schrödinger equations, whose non-vanishing gain functions detect the occurrence of the modulational instability, the stability spectra of the 3WRI system possess new topological components, whose associated gain functions are different from those characterising the modulational instability. By drawing on a recent link between modulational instability and the occurrence of rogue waves, we speculate that linear instability of baseband-type can be a necessary condition for the onset of rogue wave types in the 3WRI system, thus providing a tool to predict the subsequent nonlinear evolution of the perturbation.
Image synthesis from an ethical perspective
Authors: Bendel Oliver 
Published: September 2023

AbstractGenerative AI has gained a lot of attention in society, business, and science. This trend has increased since 2018, and the big breakthrough came in 2022. In particular, AI-based text and image generators are now widely used. This raises a variety of ethical issues. The present paper first gives an introduction to generative AI and then to applied ethics in this context. Three specific image generators are presented: DALL-E 2, Stable Diffusion, and Midjourney. The author goes into technical details and basic principles, and compares their similarities and differences. This is followed by an ethical discussion. The paper addresses not only risks, but opportunities for generative AI. A summary with an outlook rounds off the article.
Effect of soil bioremediation on soil microbial community structure aimed at controlling tobacco bacterial wilt
Authors: Liu Yanxia , Li Han , Li Xiang , Zhang Heng , Zhu Jingwei , Peng Yu , Sun Guangjun , Xu Jian 
Published: September 2023

Abstract
Rebuilding soil healthy microbiota is very important for preventing bacterial wilt. A 3-year-long field trial was conducted in China as follows: T1 (conventional fertilization), T2 (T1 + liming), T3 (T1 + bioorganic fertilizer), and T4 (T2 + bioorganic fertilizer). Fluorescence quantitative PCR and high-throughput sequencing were employed to study the dynamics of Ralstonia solanacearum population, microbial community, and network organizations between bacteria and quality-related variables. After 3 years of bioremediation, the control efficacy of tobacco bacterial wilt reached 61.30% and the occurrence delayed by approximately 40 days in T4, which had the highest tobacco yield and output value. The pathogen population of T4 remained below 106 copies/g soil during the entire growth period. Role-shifts prevailed among the network members. Microbes were unipathically associated with variables in T1 but multiplex in T4. In conclusion, soil bioremediation rebuilds a healthy soil microbiota and forms a more interactive and relevant micro-system, thus effectively controlling tobacco bacterial wilt.

Key points
• This is the first time to effectively bio-control tobacco bacterial wilt in practical production in China, as well as to high-efficiently use the organic waste, thus promoting the organic cycling of the environment.
• Soil bioremediation can effectively control soil-borne disease by rebuilding soil healthy microbiota and reducing abundance of pathogenic bacteria, thereby to prevent the soil borne disease occurrence.
• After the soil remediated, microbes associated with soil and tobacco characteristics changed from unipathical to multiplex, and the keystone species play different roles compared with the original soil, thus signifying the complexity of multi-species interactions and achieving a closely relevant micro-system, which was ecologically meaningful to the environment.
On the Role of the Displacement Current and the Cattaneo’s Law on Boundary Layers of Plasma
Authors: Aarach Nacer , De Anna Francesco , Paicu Marius , Zhu Ning 
Published: September 2023

AbstractIn the present paper, we aim to mathematically analyse the role of the displacement current and the Cattaneo’s law on the boundary-layer theory of plasma, when the corresponding characteristic speed is relativistic. We restrict our analysis to two-dimensional flows and we study the asymptotic limit of the Navier–Stokes–Maxwell equations with Cattaneo’s law near a bounding flat line, when the Hartmann, Reynolds and magnetic Reynolds numbers proportionally diverge to $$\infty $$
∞
. The goal of this paper is twofold. We first show that the extended version of the Navier–Stokes–Maxwell equations leads to a new family of boundary layers, which are hyperbolic both on the momentum equation and the Ampere’s law. Secondly, we address the well-posedness of the derived equations and show the existence of global-in-time analytic solutions for small initial data. Our modelling highlights which conditions on the dimensionless parameters allow to interpret the proposed system as boundary layers with thickness typical of Prandtl or Hartmann. Furthermore, our development shows that the conditions related to Hartmann might be more physically acceptable. Finally, our analysis suggests that the Cattaneo’s law and the displacement current might indeed stabilize the derived system in terms of existence of global-in-time analytic solutions.
The impact of a second MRI and re-biopsy in patients with initial negative mpMRI-targeted and systematic biopsy for PIRADS ≥ 3 lesions
Authors: Zattoni Fabio , Pereira Leonor J. Paulino , Marra Giancarlo , Valerio Massimo , Olivier Jonathan , Puche-Sanz Ignacio , Rajwa Pawel , Maggi Martina , Campi Riccardo , Amparore Daniele , De Cillis Sabrina , Junlong Zhuang , Guo Hongqian , La Bombarda Giulia , Fuschi Andrea , Veccia Alessandro , Ditonno Francesco , Marquis Alessandro , Barletta Francesco , Leni Riccardo , Serni Sergio , Kasivisvanathan Veeru , Antonelli Alessandro , Dal Moro Fabrizio , Rivas Juan Gomez , van den Bergh Roderick C. N. , Briganti Alberto , Gandaglia Giorgio , Novara Giacomo 
Published: September 2023

Abstract
Objective
To evaluate the proportions of detected prostate cancer (PCa) and clinically significant PCa (csPCa), as well as identify clinical predictors of PCa, in patients with PI-RADS >  = 3 lesion at mpMRI and initial negative targeted and systematic biopsy (initial biopsy) who underwent a second MRI and a re-biopsy.

Methods
A total of 290 patients from 10 tertiary referral centers were included. The primary outcome measures were the presence of PCa and csPCa at re-biopsy. Logistic regression analyses were performed to evaluate predictors of PCa and csPCa, adjusting for relevant covariates.

Results
Forty-two percentage of patients exhibited the presence of a new lesion. Furthermore, at the second MRI, patients showed stable, upgrading, and downgrading PI-RADS lesions in 42%, 39%, and 19%, respectively. The interval from the initial to repeated mpMRI and from the initial to repeated biopsy was 16 mo (IQR 12–20) and 18 mo (IQR 12–21), respectively. One hundred and eight patients (37.2%) were diagnosed with PCa and 74 (25.5%) with csPCa at re-biopsy. The presence of ASAP on the initial biopsy strongly predicted the presence of PCa and csPCa at re-biopsy. Furthermore, PI-RADS scores at the first and second MRI and a higher number of systematic biopsy cores at first and second biopsy were independent predictors of the presence of PCa and csPCa. Selection bias cannot be ruled out.

Conclusions
Persistent PI-RADS ≥ 3 at the second MRI is suggestive of the presence of a not negligible proportion of csPca. These findings contribute to the refinement of risk stratification for men with initial negative MRI-TBx.
Long term efficacy of prosthetic inguinal herniorrhaphy concomitant with robot-assisted laparoscopic radical prostatectomy
Authors: Peixoto Nelson , Grobet-Jeandin Elisabeth , Schoofs Fabian , Windisch Olivier , Iselin Christophe , Benamran Daniel 
Published: September 2023

Abstract
Purpose
Patients who undergo robot-assisted laparoscopic radical prostatectomy (RARP) may present concurrent or secondary inguinal hernia (IH). Surgical repair of IH simultaneously with RARP has been reported. We aimed to assess the long-term efficacy of concurrent prosthetic IH repair with RARP.

Methods
Data for consecutive patients undergoing concurrent IH repair with RARP for localized prostate cancer at our institution between 2006 and 2017 were retrospectively analysed. Patients were matched based on age, BMI, and year of surgery, with patients undergoing RARP alone. IH repair was performed with a polyester mesh. Efficacy of IH repair was the primary outcome. Patient characteristics, perioperative data, recurrence and treatment were recorded.

Results
A total of 136 men were included, 50% treated by RARP and concurrent IH, 50% by RARP alone. Mean age was 65 years (SD 6) and mean BMI 26.8 (SD 2.5). IH was diagnosed preoperatively in 42 patients (62%) or intraoperatively in 26 patients (38%). A total 18 patients (26%) had bilateral hernias and 50 patients had unilateral hernias (right 31%, left 43%). There was no significant difference between the two groups regarding perioperative data. The herniorrhaphy added 34 min to the operative time (p < 0.001). After a mean follow-up of 106 months [SD 38], 9 patients (13%) presented recurrence of IH, with a mean time to recurrence of 43 months [SD 35]. Age was significantly associated with IH recurrence (p = 0.0007).

Conclusion
Concomitant IH repair and RARP appear to be a safe procedure with good long-term safety and efficacy, without significantly increasing morbidity.
A lightweight neural network designed for fluid velocimetry
Authors: Manickathan Lento , Mucignat Claudio , Lunati Ivan 
Published: September 2023

AbstractWe devise a novel lightweight image matching architecture (), which is designed and optimized for particle image velocimetry (PIV). is a convolutional neural network (CNN) that performs symmetric image matching and employs an iterative residual refinement strategy, which allows us to optimize the total number of refinement steps to balance accuracy and computational efficiency. The network is trained on kinematic datasets with a loss function that penalizes larger gradients. We consider a six-level () and a four-level () version of the network and demonstrate that they are considerably leaner and faster than a state-of-the-art network designed for optical flow. reconstructs the velocity field from synthetic and experimental PIV images with an accuracy comparable or superior both to existing CNNs as well as to state-of-the-art cross-correlation methods (i.e., a commercial implementation of ). Although less accurate, allows a significant reduction of the computational costs with respect to any other method considered. All CNNs prove more robust than with respect to particle loss and allow effective error reduction by increasing the particle seeding density. Thanks to reduced computational cost and memory requirement, we envision the deployment of on low-cost devices to provide affordable, real-time inference of the flow field during PIV measurements.