bluuebunny/crossref_metadata_2025_split huggingface dataset:
China's Carbon Emissions Peaking Pathway in the Post-COVID-19 Era
Authors: Liu Da , Wang Shengyan , zhao Xudong , Wang Jiaying 
Published: May 2023

Abstract
Several countries have weakened the carbon emission objectives to immediately revive the economy in the post-COVID-19 era. Therefore, it is a challenge worth addressing to readjust the economic development and carbon emissions after the COVID-19 pandemic. From the perspective of China's carbon emissions, this study shapes a multi-objective dynamic optimization model based on the material capital input and R&D support aspects. The proposed model imitates China's economic development, energy consumption, and carbon dioxide (CO2) emissions. The model provides theoretical suggestion for the government to revive economic development and reduce carbon emissions. In addition, this research paper compares the evolutionary path of carbon peak under the two scenarios. The first scenario requires maintaining the pre-epidemic development state and pace of carbon emission reduction, referred to as the baseline scenario (BS). The second scenario is termed the optimal scenario (OS) based on the model calculation. The study findings exhibit that China is not able to accomplish the 2030 CO2 emission peak objective, under the BS. However, China under the OS shall expectedly accomplish the 2030 carbon peak objective ahead of schedule, while the peak CO2 emissions shall be around 11.28 billion tons. Reportedly, at least 788 million tons of CO2 reduction contrasted with the BS. Further, there is an 80.35% decline in energy intensity as compared to 2005. Consequently, the study results contribute theoretical guidance for the "green recovery" of China's economy and the adjustment of carbon emission reduction’s path after the COVID-19 epidemic. Consistent with this, the research method also contributes to the theoretical research on carbon emissions at the national level while extending a new research perspective for the economic- and environmental fields.
Weizmannia coagulans functions as a heat-stress protective probiotic via modulation of the pyridoxal-oxalate interaction
Authors: Miyamoto Hirokuni , Ito Kayo , Honda Fuyuko , Matsuura Makiko , Ishii Chitose , Tsuji Naoko , Nakaguma Teruno , Ito Toshiyuki , Suda Wataru , Shindo Chie , Nakanishi Yumiko , Ohno Hiroshi , Kikuchi Jun , Kurotani Atsushi , Michibata Ryounosuke , Yamada Ryouichi , Takahashi Yosuke , Kodama Hiroaki , Satoh Takashi 
Published: May 2023

Abstract
Global warming has become an urgent issue, and heat stress protective materials should be developed to manage human life and animal husbandry. Here, the heat stress protective effects of the thermostable probiotic Weizmannia coagulans SANK70258 were clarified using a broiler model under thermal conditions in an artificial climate facility. Probiotic exposure promoted growth under the thermal conditions. Based on machine learning (ML) data obtained after omics analysis, structural equations and causal inference for broiler growth under heat-stress estimated the strong relationship with pyridoxal involved in the reduction of hepatic oxalic acid, which is responsible for cold sensitivity. In addition, the relative abundance of the genus Pseudomonas, which may be decrease pyridoxal, were at a low level after exposure of W. coagulans under heat-stress. Thus, this study highlights a novel aspect of W. coagulans as a probiotic candidate that modulates the mechanism of heat tolerance related to the cold sensitivity.
Physico-chemical, mineral, and chemical variation of dredged sediments caused by electrokinetic remediation
Authors: Zein-Eddin Ahmad , Kanbar Hussein J , Ammami Mohamed-Tahar , Benamar Ahmed 
Published: May 2023

Abstract
Sediment contamination is a growing worldwide issue that poses significant risks to human health. Among other remediation techniques, electrokinetic remediation (EKR) is a novel method for addressing both organic and inorganic pollutants. Dredged sediments can be reused in an environmentally sustainable manner after removing or reducing unwanted chemicals. This study aims to examine treat carbonate-rich estuarine sediments by EKR and to assess the consequent physico-chemical, mineral, organic, and chemical changes. To achieve this, a series of laboratory experiments were carried out on dredged sediments from Tancarville, France, using a 360 ml setup. The electric current, voltage, electroosmotic flow, pH, and electric conductivity were monitored during treatment. The treated sediments were then sectioned and analyzed for physico-chemical properties as well as mineral (mainly carbonate), organic, and metal contents. The results showed that the variations in running parameters affected the pH of the medium, leading to changes in carbonate dissolution. This, in turn, reduced buffering capacity and removed associated metals. Moreover, calcium and other released metals could be transported within the system or competing with other surface-bound metals. Statistical data indicated that the physico-chemical processes that occur in the anode and cathode chambers depended largely on the experimental conditions (mainly current density and voltage gradient). Although Cl and Mn contents were reduced from the sediments without any direct link to pH, Mg was only redistributed in the sediments within the setup. Finally, by monitoring physico-chemical parameters, characterizing sediment composition before and after treatment, and applying statistical approaches, the remediation process was better understood. This methodology can be used to treat sediments and other environmental matrices effectively.
Do animation videos increase participation in national health surveys? A randomised controlled trial
Authors: Christensen Anne Illemann , Lau Cathrine Juel , Poulsen Hanne Stald , Ekholm Ola 
Published: May 2023

Abstract
Background: Declining response proportions in surveys have been observed internationally. Improving response proportions is important for the generalizability of the outcome. The aim of this study is to examine the potential of animation videos to improve response proportions and sample composition in health surveys.
Methods: A randomized trial was embedded in the Danish National Health Survey 2021 (n=186,113) where the use of animation videos in the digital invitation letter was tested as a mean to increase participation. The effect of both targeted videos and a general video was tested. The sample was randomized into 4 groups; 1) individuals with non-western background and a non-Danish citizenship (n=9,956), 2) men aged 16-24 years (n=12,481), 3) women aged 75 years or older (n=7,815) and 4) the remaining individuals (n=155,861). The 4. group was divided into 2 equal sized groups; a group receiving the general video and a control group receiving no video. Each of the first 3 groups was subsequently divided into 3 subgroups with 25% receiving the target group video, 25% receiving the general video and 50% receiving no video.
Results:
The use of animation videos resulted in similar or slightly lower response proportions overall compared to the control group. The different animation videos were found to have heterogeneous effects on response proportions. A positive effect was found among men aged 16-24 years before the delivery of the postal reminder for the targeted animation video compared to no video (odds ratio: 1.13; 95% confidence interval: 1.02–1.26). Overall, the targeted animation videos tended to produce higher response proportion than the general animation video. The difference was only statistically significant among young men aged 16-24 years before the delivery of the postal reminder.
Conclusions:
The heterogeneous effects of the videos suggest that there is some potential for the use of animation videos to improve response proportions and sample composition. The content, target group and timing of evaluation seem to be important for the animation videos to be successful. This warrants further research to better identify in which contexts, in which subgroups and under which circumstances, animation videos are useful to increase response proportions.
Direct Medical Cost of Breast Cancer Care in Lome: Case of Sylvanus Olympio University Hospital and International Cancer Centre
Authors: KETEVI Ameyo Ayoko , Adani-Ifè Solange , Bassowa Akila , Bessolo Lysiane , Andele Komlan Alessi , Katende Bidilukinu , Douaguibe Baguilane , Ajavon Dede Régine Diane , Rahim Achraf Adou , Aboubakari Abdoul Samadou , Akpadza Koffi 
Published: May 2023

Abstract
Introduction: With 11.7% new cases worldwide in 2020, female breast cancer is not only the first among gynaecological cancers, it is also the first cancer worldwide. Also, disease stage during diagnosis is an important cost predicting factor.
Methods: It was a transversal descriptive study carried out in the Obstetrics and Gynaecology unit of the Sylvanus Olympio University Hospital (SO UH) and in the International Cancer Centre of Lome (ICCL) during July and august of the year 2022.
Results: Only 146 patients were enrolled in our study, with a participation rate of 30.87%. The mean age of the patients was 48.9 ± 11.7 years with extremes of 25 and 77 years. Fifty one patients (39%) were resellers. Sixty four patients (43.8%) attended secondary education. The median cost of breast cancer diagnosis was 182080 FCFA ]55680; 487680] FCFA. The median cost of chemotherapy was 1640790 FCFA ]199820; 5208885] FCFA. The median cost of surgical treatment of breast cancer was 230 320 FCFA ]135240; 368060] FCFA. The median cost of hormonal treatment was 206200 FCFA ]36750; 494850] FCFA. The median cost of radiotherapy was 1 765 000 FCFA ]1715000; 2030 000] FCFA. Of the 146 patients, 46 had not undergone any other complementary tests apart from diagnostic tests. The median cost of the tests carried out as part of the pre-therapeutic assessment and follow-up was 21 500 FCFA (0; 824 760] FCFA. The direct medical cost of breast cancer management was 119200 FCFA [36616- 1604669] FCFA for patients with health insurance (17.1% of patients).
Conclusion: The direct medical cost of breast cancer treatment is higher than the average household income in Togo. The question of what measures could be taken to increase adherence to treatment by patients living with this cancer and to reduce the large number of long-lost patients is still pending.
Implementation Early Design of Prototype EEWS Development in Indonesia
Authors: Pramono Sigit , Utama Muhammad Reza July , Swastikarani Rika , Sabtaji Agung , Wijaya Angga , Utomo Fajar Budi , Sakti Artadi Pria , Rudiyanto Ariska , Reza Dewintha Tresna , Owen Robert , Miftakhunnisa Aurora Fajri , Adi Suko Prayitno , Muzli Muzli , Karnawati Dwikorita 
Published: May 2023

Abstract
Tectonic regimes in Indonesia caused the potential occurrence of the earthquake with the variated impact in Indonesia. It could be a threat to people, infrastructure, and economic aspects in Indonesia. All source types such as subduction zones are the big-one event that has been considered to anticipate as part of mitigation implementation for reducing potential victims. Almost all the regions in Indonesia have the probability to be a destructive region by earthquakes. One cluster that is related to that potential threat is Java Island and Sunda strait. The earthquake early warning system (EEWS) is a part mitigation system that has the goal to reduce the impact of destruction by infrastructure collapsed by the earthquake. BMKG (Meteorological Climatological and Geophysical Agency) has committed to making the area denser instruments distribution in the earthquake early warning area. It will spread close to the subduction zone and fault distribution Strong Motion accelerometers and intensitymeter sensors have been installed since 2010, then 2019 have been initiated to develop EEWS in Indonesia for instrument response. Sunda strait and the Southern part of Java Island are a region which has the potential to produce destructive earthquakes which have an impact until the capital city of Indonesia, Jakarta city. The sequence of EEWS development in Indonesia will be started with the utilization of EEWS for some kind of operational system in transportation. It is very important due to the direct impact to people's safety and their lives. Besides using the existing 303 sensors which consist of an accelerometer and intensitymeter, in this project BMKG will use a new 1 accelerometer and 50 intensitymeter sensors in Banten Province, West Java Province, Lampung Province and Jakarta Province. Processing module in this system uses a modified eBEAR module which has many different methods rather than the basic eBear module. The mode of dissemination system is developed by variated modes such as web-based, cube receiver, and mobile phone applications. While developing modules and applications, the empirical formula will be formed by the research of local characteristics to represent actual conditions in certain areas of Indonesia's Earthquake Early Warning System. The EWS is a big challenge for BMKG, due to many things that must be done in order to have a successful EEWS program according to Indonesian conditions.
Nuclear isoform of RAPH1 interacts with FOXQ1 to promote progression and radioresistance in triple-negative breast cancer through the STAT3 pathway
Authors: Xing Peng , Liu Qun , Cao Yu , Wei Xiaolin , Dong Huiting , Cui Mengyao , Guan Shu , Liu Bo , Wang Xu 
Published: May 2023

Abstract
Radioresistance limits the efficacy of radiotherapy against triple-negative breast cancer (TNBC). Epithelial-to-mesenchymal transition (EMT) is closely related to tumor radioresistance. In this work, we attempted to identify the key EMT-related transcription factor(s) that can induce radioresistance in TNBC cells. A set of 44 EMT transcription factors were analyzed in parental and radioresistant TNBC cell lines. The function of FOXQ1, a differentially expressed transcription factor, was determined in TNBC radioresistance. FOXQ1-interacting proteins were identified by co-immunoprecipitation and mass spectrometry. Compared with parental cells, FOXQ1 was significantly upregulated in radioresistant TNBC cells. Silencing of FOXQ1 increased the radiosensitiviy of radioresistant TNBC cells both in vitro and in vivo. FOXQ1 associated with a nuclear isoform of RAPH1 (named RAPH1-i3) in radioresistant TNBC cells. Overexpression of RAPH1-i3 enhanced TNBC cell proliferation and migration, and most interestingly, induced radioresistance in parental TNBC cells when co-expressed with FOXQ1. Mechanistically, co-expression of RAPH1-i3 and FOXQ1 activated the STAT3 signaling pathway and increased the expression of CCND1, MCL1, Bcl-XL, MMP2, and MMP9. Depletion of RAPH1-i3 impaired the radioresistance of radioresistant TNBC cells. Additionally, RAPH1-i3 upregulation was associated with advanced tumor stage and reduced disease-free survival in TNBC patients. These results collectively show that RAPH1-i3 interacts with FOXQ1 to promote TNBC progression and radioresistance via activation of STAT3 signaling. RAPH1-i3 and FOXQ1 may represent therapeutic targets for overcoming the radioresistance of TNBC.
Liver glycogen as a sensitive indicator of food limitation in Delta Smelt
Authors: Dhayalan Tena , Tran Franklin , Hung Tien-Chieh , Senegal Taylor , Mora Vanessa , Lewis Levi , Teh Swee , Hammock Bruce Graham 
Published: May 2023

Abstract
Assessing habitat quality is a major goal of conservationists and restoration practitioners, but to associate habitat quality with biomarkers of vagile animals, the biomarkers must respond rapidly. Here we identified a biomarker capable of rapidly detecting food limitation in the imperiled Delta Smelt (Hypomesus transpacificus), a pelagic fish endemic to the San Francisco Estuary (SFE). We conducted an experiment with fed and unfed treatments of hatchery-raised, sub-adult Delta Smelt that were sampled at 12 time points: 0, 1, 2, 3, 4, 5, 6, 7, 9, 11, 14, and 21 days. We then compared four biomarkers using Day 21 fish: RNA/DNA in liver, triglycerides in liver, glycogen in liver, and glycogen in muscle. Of the three liver endpoints, glycogen had the largest, most significant difference between treatments at Day 21, so we compared it to muscle glycogen across all time points. Liver glycogen declined after just one day of fasting and remained depressed in the fasting treatment across all subsequent time points. Muscle glycogen also responded rapidly, taking only two days to decline in the fasting treatment, but the difference was small and inconsistent across subsequent time points. When applied to hatchery-released Delta Smelt collected from the SFE, we found that liver glycogen concentrations were less than half that of the fed hatchery fish, consistent with the hypothesis of food limitation in the wild, but also several other potential causes. This study highlights the utility of biochemically determining liver glycogen concentrations of wild-caught Delta Smelt to provide insight into local habitat quality.
Increase in Clostridioides difficile infection resulting from over usage of antibiotics during COVID 19 pandemic
Authors: PILLAI SREEHARI KARUNAKARAN , Shuriqy Naseem 
Published: May 2023

Abstract
Healthcare-associated infections (HAIs) due to Clostridioides difficile infections (CDIs) are a significant public health problem globally. The emergence of the novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in 2019 has exacerbated the situation. Elderly and chronically ill individuals are particularly vulnerable to COVID-19, and gastrointestinal (GI) symptoms are increasingly recognized as essential symptoms of COVID-19. Bacterial infections in COVID-19 patients are prevalent, and the rates of Clostridioides difficile infection (CDI) are high and associated with antibiotic use. The study aims to investigate the correlation between CDI and community antibiotic usage patterns during COVID-19 in 2021 compared to the previous year to identify the impact on overall CDI infection rates. The study design is a non-interventional retrospective study evaluating antibiotic usage patterns in CDI patients during the pandemic, and the data will be analysed based on the number of patients and test positivity rates. The preliminary findings of the study reveal a 27% increase in the number of symptomatic CDI infections in 2021 as compared to pre-COVID years.
The Eastern Mediterranean Sea as dominant driver of interannual rainfall variability in the Sahel
Authors: Gaasbeek Timmo , Ent Ruud van der , Coumou Dim , Keulers Sander , Haarsma Rein 
Published: May 2023

Abstract
Many factors have been suggested to explain variability and change in Sahel rainfall. Of those, sea surface temperature (SST) in the Eastern Mediterranean Sea (EMS) and zonal wind and moisture flux south of the Sahel show strong correlations. Based on observational and reanalysis data on temperature, pressure, wind and moisture flux, this paper identifies a mechanism that explains and connects both correlations. The mechanism hinges on the Jebel Marra massif and the Ethiopian highlands, where the mesoscale convective systems (MCSs) develop that bring most of the rain to the Sahel. We find that cold SST anomalies in the EMS between June and September cause a greater trans-Sahara temperature contrast and coincide with high pressure over Libya, resulting in stronger northerlies towards Sudan. This prevents Tropical Atlantic moisture from reaching the MCS genesis regions, which reduces the seasonal northward spread of Sahel rainfall and of the Atlantic intertropical convergence zone, which in turn suppresses the development of the west-African westerly jet and the African westerly jet and inhibits Atlantic moisture from reaching the MCS genesis region, thus further reducing Sahel rainfall. Anomalous moisture transport from the Mediterranean does not play a role. Mediterranean SST variability raises questions about the future development of Sahel rainfall.
WITHDRAWN: Immunogenicity of a cold-chain friendly and long-term stable HIV multi-epitope protease cleavage sites (MEPCS)-mRNA-LNP vaccine.
Authors: Mandal Subhra , Ghosh Jayadri , Lohani Saroj , Zhao Miaoyun , Cheng Yilun , Luo Ma , Li Qingsheng 
Published: May 2023

Abstract

The failure of HIV vaccine clinical trials calls for novel vaccine development strategies. Studies on HIV highly exposed seronegative sex workers showed that focused virus-specific CD8+ T-cell responses are associated with the protection. Following the unconventional HIV vaccine approach targeting 12 highly conserved sequences surrounding the protease cleavage sites (PCS), we designed multi-epitope PCS mRNA-loaded lipid nanoparticles (MEPCS-mRNA-LNP) to promote more efficient antigen presentation. The modified LNP formulation produced stable and cold-chain-friendly MEPCS-mRNA-LNP. The mice study showed the vaccinated group generates PCS-specific CD8+ memory T-cells with cytotoxic function, both systemically and at the HIV-targeted tissue sites (like HESN group), with T-polyfunctional response. As expected, little to no significant activation of CD4+ T-cells was observed. The proof-of-concept study indicates that the MEPCS-mRNA LNP vaccine approach induces immunological memory against highly conserved HIV pro-polyprotein (limiting HIV’s mutability). The MEPCS-mRNA LNP vaccine could be a potential candidate for an effective prophylactic HIV vaccine.
Satellite monitoring of war urban damage with a temporal knowledge-guided deep learning scheme
Authors: Zhang Liqiang , Hou Zhengyang , Qu Ying , Shi Qian , Yu Qiwei , Zhao Yuanyuan , Tang Hong , Wang Yuebin , Li Xingang , Li Yang , Peng Shuwen , Yao Xin , Zhou Chenghu 
Published: May 2023

Abstract
Since 1990, between 40 and 68 countries, home to 46–79% of the population in the world were involved in armed conflict per year [1–3], which have caused huge socio-economic costs and severe casualties. Geotargeting is a central challenge for comprehensive assessments of wars and humanitarian assistance: it remains a difficult task to rapidly identify severe destructive zones with traditional or satellite-based methods. To overcome the challenge, we propose the first tempo- ral knowledge-guided detection scheme (TKDS) for satellite urban destruction monitoring. By integrating the proposed pixel-based Transformer model (PtNet) into the efficient TKDS scheme (TKDS-PtNet), we achieve the best destruction detection performance in the Syrian civil war and Russia-Ukraine war with high or medium resolution satellite imagery. Even using medium-resolution satellite images, the performance of the TKDS-PtNet model outperforms the state-of-the-art methods by 44.4 (more than twice as high as the latter, 72.4 vs 28.0) in terms of F1 score in six Syrian cities, and 36.1 (84.6 vs 48.5) in four Ukrainian cities. Our findings located 1,652 severely damaged buildings in Mariupol, Ukraine, including various urban infrastructures such as 81.5% (1,346) houses/apartments, 4.0% (66) industrial, as well as 11 garages, 2 schools, 2 kindergartens, and 1 sports center. Our scheme provides a low-cost, reliable, highly flexible, and generalizable solution for urban destruction monitoring in data-sparse environments. It can be applied to any urban context to near real-time monitor damage caused by wars, earthquakes, or extreme weather events, and approximate the spatio-temporal distribution of the damages to aid relief efforts, in addition to the estimation of potential rehabilitation costs.
Certain subclasses of analytic functions and bi-univalent functions defined
on the unite disc
Authors: Lashin Abdel Moneim , Badghaish Abeer , Algethami Badriah 
Published: May 2023

Abstract
In this paper, Motivated by $q$- calculus, we introduce and investigate new
subclasses of the analytic and bi-univalent functions defined in the open
unit disk $U$. Estimates on the first two Taylor-Maclaurin coefficients $$ and $\left \vert a_{3}\right \vert $ for the
functions belong to these new classes are obtained. Certain special cases
are also indicated.