bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on multi-objective optimal allocation of regional water resources based on improved sparrow search algorithm
Authors: Yao Zhiyuan , Wang Zhaocai , Cui Xuefei , Zhao Haifeng 
Published: June 2023

Abstract

Nowadays, the conflict between the supply and demand of water resources in many regions is becoming increasingly prominent. Scientific allocation of regional water resources has become the key to solving the contradiction. In this study, a regional multi-objective water resources optimization allocation model considering social, economic, and ecological objectives is established, and four improvement spots are introduced to the sparrow search algorithm (SSA) to form an improved sparrow search algorithm (ISSA). By testing nine benchmark functions including monotonic and multi-peaked, the search efficiency and average convergence results of ISSA are significantly enhanced compared with other intelligent algorithms. Meanwhile, this research uses Luanchuan County, Henan Province, China, as an example to solve the water resource allocation scheme for 2025 and 2030 in the region using ISSA. The results show that the overall water shortage rate decreases to 3.49 and 2.79%, respectively, under the 75% guarantee rate, resulting in an effective reduction in future water shortages. Simultaneously, the scheme proposed has sound comprehensive benefits and can provide important technical support for the refined management of water resources, which is a reference and guidance for solving the contradiction between water supply and demand at the current stage.
Sustainability indexes in water–food–energy nexus to develop strategies with respect to virtual water
Authors: Huang Shan , Zeng Fusheng 
Published: June 2023

Abstract
The management of water resources requires a correct understanding of the simultaneous management of food and energy resources. The framework of water–food–energy correlation with the approach of sustainability of resources and uses analyzes the combined management and exploitation of water, food, and energy resources with the help of scenario planning. In addition to sustainability concepts, environmental costs such as the emission of carbon dioxide from fossil fuels and its impact on the environment are also discussed. In this research, according to the five defined indicators and based on the potential of using solar energy and the possibility of exploiting renewable energy sources such as solar energy, various management scenarios have been developed. After examining the virtual water management model developed in the Hunan basin as a case study, the development of the water–food–energy nexus model and its calibration, and four scenarios including improving water use efficiency, energy saving, increasing food productivity, and nexus sustainability were developed. The results showed that the nexus strategy can provide sustainability goals according to the weight of each component. After the combined scenario, improving the efficiency of water consumption can be the component with the highest priority in the decision-making model in dry areas.
Understanding the Molecular Aspects of Vitamins in Parkinson’s Disease:
Present-day Concepts and Perspectives
Authors: Behl Tapan , Madaan Piyush , Sehgal Aayush , Makeen Hafiz A. , Albratty Mohammed , Alhazmi Hassan A. , Meraya Abdulkarim M. , Anwer Md. Khalid , Verma Raman 
Published: June 2023

Abstract:
Parkinson’s disease (PD) is designated as a convoluted nerve cell devastating disorder that encompasses the profound declination of dopaminergic (DArgic) nerve cells of the mesencephalon region. The condition is sketched by four eminent motor manifestations, namely, slow movement, muscle tension, shaking, and disrupted balance, but the pathology behind these manifestations is still vague. Modern-day medicinal treatment emphasizes curbing the manifestations via introducing a gold standard (levodopa) instead of forestalling the DArgic nerve cell destruction. Therefore, the invention and utilization of novel neuroprotective candidates are of paramount importance in overcoming PD. Vitamins are organic molecules engaged in the modulation of evolution, procreation, biotransformation, and other operations of the body. Numerous studies employing varying experimental models have promulgated a prominent linkage between vitamins and PD. Vitamins, owing to their antioxidant and gene expression modulation abilities, might be efficacious in PD therapy. Recent corroborations depict that adequate augmentation of vitamins might de-escalate the manifestations and emergence of PD; however, the safety of daily vitamin intake must be considered. By assembling the comprehensive information obtained from existing publications via searching various renowned medical portals, the investigators render in-depth insights into the physiological association amongst vitamins (D, E, B3, and C) and PD and concerned pathological processes and their safeguarding actions in varied PD models. Furthermore, the manuscript delineates the remedial aptitude of vitamins in PD therapy. Conclusively, augmentation of vitamins (owing to their antioxidant and gene expression regulation capabilities) might appear as a novel and terribly efficacious ancillary therapeutic approach for PD.
Therapeutic Effect and Mechanism Prediction of Fuzi-Gancao Herb
Couple on Non-alcoholic Fatty Liver Disease (NAFLD) based on Network
Pharmacology and Molecular Docking
Authors: Liu Kejia , Yang Xu , Zhang Guihong , Xiang Zheng 
Published: June 2023

Background:
Fuzi-Gancao herb couple is one of the most common herb couples involved
in the TCM formula, which was used for the treatment of chronic diseases. The herb couple
has a hepatoprotective effect. However, its main components and therapeutic mechanism are not
yet clear. This study aims to elucidate the therapeutic effect and mechanism of the Fuzi-Gancao
herb couple on NAFLD from animal experiments, network pharmacology, and molecular docking.

Methods:
60 Male C57BL/6 mice (20 g ± 2 g) were randomly divided into six groups including the
blank group (n=10) and NALFD group (n=50). The mice of the NALFD group were fed with a
high-fat diet for 20 weeks to establish the NAFLD model and the NALFD mice were randomly divided
into five groups including positive group (berberine), model group and F-G groups with
three dosages (0.257, 0.514, 0.771 g/kg) (n=10). After 10 weeks of administration, the serum was
collected for the analysis of ALT, AST, LDL-c, HDL-c, and TC, and liver tissues were collected
for pathological analysis. The TCMAS database was used to collect the main components and targets
of the Fuzi-Gancao herb couple. The GeneCards database was used to collect NAFLD-related
targets, and the key targets were obtained by intersecting with herbal targets. The diseasecomponent-
target relationship diagram was constructed by Cytoscape 3.9.1. The obtained key targets
were imported into the String database to obtain the PPI network, and imported into the DAVID
database for KEGG pathway analysis and GO analysis. Finally, the key targets and key gene
proteins were imported into Discovery Studio 2019 for molecular docking verification.

Results:
In this study, H-E staining indicated the pathological changes of liver tissue in Fuzi-
Gancao groups were significantly improved, and the levels of AST, ALT, TC, HDL-c, and LDL-c
in serum of Fuzi-Gancao groups decreased in a dose-dependent manner, compared with the model
group. 103 active components and 299 targets in the Fuzi-Gancao herb couple were confirmed in
the TCMSP database and 2062 disease targets in NAFLD were obtained. 142 key targets and 167
signal pathways were screened, such as the AGE-RAGE signaling pathway in diabetic complications,
HIF-1 signaling pathway, IL-17 signaling pathway, TNF signaling pathway, and so on. The
main bioactive ingredients of Fuzi-Gancao herb couple in the treatment of NAFLD are quercetin,
kaempferol, naringenin, inermine, (R)-norcoclaurine, isorhamnetin, ignavine, 2,7-Dideacetyl-2,7-
dibenzoyl-taxayunnanine F, glycyrol mainly involving IL6, AKT1, TNF, TP53, IL1B, VEGFA and
other core targets. Molecular docking analysis indicated that there is a good affinity between the
key components and the key targets.

Conclusion:
This study preliminarily explained the main components and mechanism of the Fuzi-
Gancao herb couple in the treatment of NAFLD and provided an idea for subsequent research.
N-Heterocyclic Compounds, In silico Molecular Docking Studies, and In
vitro Enzyme Inhibition Effect against Acetylcholinesterase Inhibitors
Authors: Guzel Abdussamat , Isık Zeynep , Gok Yetkin , Taskin-Tok Tugba , Aktas Aydın 
Published: June 2023

Background:
This work contains the synthesis of seven new N-heterocyclic compounds bearing imidazole, benzimidazole, pyridine, and morpholine moieties.

Objective:
We aimed to synthesize N-heterocyclic compounds for a more effective drug candidate to increase the amount of acetylcholine in synapses in Alzheimer's disease. All compounds were characterized by 1H NMR, 13C NMR, FTIR and elemental analysis. Enzyme inhibition activity of all compounds against acetylcholinesterase was investigated, which is an indirect treatment for Alzheimer's. Molecular docking was applied to estimate the binding energy of these compounds to the acetylcholinesterase.

Methods:
All compounds were synthesized from reactions of 2 equivalents of N-heterocyclic starting material and 1 equivalent of 4,4'-bis(chloromethyl)-1,1'-biphenyl. The inhibition parameters of IC50 and Ki were calculated by the spectrophotometric method. AutoDock4 was used to define the binding pose of the compounds.

Results:
Ki values were found in the range of 80.03±19.64 to 5014.98±1139.60 nM for AChE as an enzyme inhibition strategy, which is an important parameter for the treatment of neurodegenerative such as Alzheimer's disease. In this study, molecular docking is exerted to predict the binding energy of heterocyclic compounds (especially 2, 3, and 5) against acetylcholinesterase enzyme. Their docking binding energies are in good agreement with experimental findings.

Conclusion:
These new syntheses are drugs that can be used as AChE inhibitors in Alzheimer's disease.
Arthritis of the Hip Caused by Arteriovenous Malformations: A Case Report
Authors: Yu Xiao , Zhou Xiao-Qiang , Lin Jie , Zhang Jing-Yu , Li Suo-Yuan , Liu Yu-Bo , Zhou Da-Yong , Lv Jing-Huan , Chen Guang-Xiang , Xu Ren-Jie 
Published: June 2023

Background::
Arthritis of the hip caused by arteriovenous malformations (AVMs) has been rarely reported. Therefore, total hip replacement (THR) in patients with AVM-induced arthritis of the hip is challenging.

Case Summary:
We report a 44-year-old woman with aggravated right hip pain during the past decade. The patient presented with severe pain and a functional disorder of the right hip. X-ray examination revealed severely narrowed right hip joint space and abnormal trabecular bone loss in the femoral neck and trochanter area. Doppler ultrasound, magnetic resonance imaging and computed tomography angiography revealed AVMs surrounding the right hip, along with erosion. To ensure the safety of THR, we performed vascular embolization and temporary balloon occlusion of the iliac artery three times during the operation. However, serious hemorrhage occurred, which was rescued by the multimodality blood conservation strategy. THR was successfully performed, and the patient was discharged 8 d later for rehabilitation. Postoperative pathological examination showed osteonecrosis of the femoral head with malformed thick-walled vessels and focal granulomatous inflammation of the surrounding soft tissues. The Harris Hip Scale score increased from 31 to 82 at 3 mo of follow-up. The patient was followed up for 1 year, and all her clinical symptoms were significantly alleviated.

Conclusion:
Arthritis of the hip caused by AVMs is rare in clinical practice. The activity and function of the involved hip joint can be effectively treated with THR after comprehensive imaging and multidisciplinary consultation.

Core Tip::
Arthritis of the hip caused by arteriovenous malformations is rarely reported. Total hip replacement (THR) is a reliable and effective option for the
treatment of advanced arthritis of the hip. We report a 44-year-old woman with aggravated pain in the right hip during the past decade. With the
vascular intervention and multimodality blood conservation strategy. THR can be successfully performed in patients with AVM-induced arthritis
of the hip.
Development of Dermatomyositis after Pfizer BioNTeh COVID-19
Vaccine: A Case Report
Authors: Aouintia Imen , Daly Wiem , Lakhoua Ghozlane , Kaabi Widd , Charfi Ons , Debbeche Sana , Kastalli Sarrah , Zaiem Ahmed , El Aidli Sihem 
Published: June 2023

Introduction:
The Coronavirus Disease 2019 (COVID-19) pandemic led to the fast development
of vaccines, which is considered a medical advance in healthcare. With the extensive
vaccination campaign performed worldwide, many adverse events following immunization (AEFI)
were reported. Most of them were flu-like symptoms, mild and self-limiting. However, serious adverse
events, such as dermatomyositis (DM), an idiopathic autoimmune connective tissue
disease, have also been reported.

Case Presentation:
In this report, we describe a case of skin erythema, edema, and diffuse myalgia
attributed at first to Pfizer BioNTeh, COVID-19 vaccination, given the temporal relationship and
the absence of significant medical history. The causality assessment score was I1B2. However,
after completing the etiological assessment, an invasive breast carcinoma was identified, and we
retained the diagnosis of paraneoplastic DM.

Conclusion:
This study underlines the importance of completing the etiological assessment before
attributing any adverse reaction to vaccination to maintain optimal patient care.
WeChat-Based Intervention for Chinese Immigrants With Hypertension: Development and Evaluation Study
Authors: Li Wen-Wen , Toh Prisca 
Published: June 2023

Background
Despite Chinese immigrants having a higher or comparable proportion of hypertension (HTN) compared to non-Hispanic White and Hispanic individuals, there are no effective technology-based intervention studies that target HTN management in Chinese immigrants in the United States.

Objective
The aim of this study was to develop and pilot-test the efficacy of a culturally and linguistically sensitive social media–based intervention (WeChat) for Chinese immigrants to improve blood pressure (BP) control, antihypertensive medication adherence, and self-efficacy.

Methods
The study was conducted in 2020 with a pre- and posttest design (N=20). A WeChat-based intervention was implemented using one 20-minute video presentation plus one 20-minute nurse counseling session via WeChat at the baseline, followed by 4 biweekly 20-minute nurse counseling sessions via WeChat calls. The primary outcome (BP control) and secondary outcomes, including medication adherence and self-efficacy in HTN management, were measured at baseline and at 6 months.

Results
The participants’ mean age was 68.9 (SD 10.2; range: 51-86) years. The majority of the participants were female (n=13, 65%), had a high school degree or less (n=15, 75%), were married (n=16, 80%), not religious (n=13, 65%), and not employed (n=12, 60%). The results showed that the mean baseline systolic BP was 131.43 (SD 9.61) mmHg, and the mean diastolic BP was 79.79 (SD 9.62) mmHg. The 6-month outcome showed a reduction of systolic BP (–0.74, SD 9.18 mmHg; P=.05) and diastolic BP (–0.96, SD 6.92 mmHg; P=.001). The mean score for medication adherence at baseline was 4.50 (SD 1.70), and it significantly improved to 3.65 (SD 1.18) at 6 months (reversely scored; possible range was 1-5, with 1 being the best score; P=.001). Self-efficacy in HTN management had a trend in reduction from a baseline score of 8.28 (SD 1.25) decreasing to 7.93 (SD 1.48) at 6 months, with a mean difference of 0.34 (SD 2.02), with a score of 0 indicating the lowest self-efficacy and a score of 10 indicating the highest self-efficacy.

Conclusions
Our WeChat-based HTN management program showed a significant improvement in diastolic BP and medication adherence as well as a trend of reduction for systolic BP and self-efficacy in managing HTN in Chinese immigrants. Compared to the traditional health care system, the proposed WeChat-based HTN management program has a low cost and is easy to implement. Thus, further investigation is recommended to generate further results. This intervention should be tested across different regions and clinical settings to verify the findings. The long-term goal is to implement the intervention in clinical settings to help Chinese immigrants at large achieve better HTN management.
Kontrol Motor DC dengan Kendali Linear Quadratic Regulator dan Filter Kalman Menggunakan GUI MATLAB
Authors: Hudati Imroatul , Wijayakusuma Nurul Izzah , Ismail Aditya Yusuf , Barus Alfonzo Aruga Paripurna , Budianto Hendi 
Published: June 2023

Abstract – DC motor is one of the electronic devices that is used in the robotic, industry and sometime can be found in daily life. DC motors usage is quite a lot, where the user is expected to be able monitor the speed or the position of the DC motor and be able to make adjustments. Noise is a part that cannot be ignored in controlling the motor DC speed. Numerous studies have been conducted. Previous research monitored the system response without considering the noise. The aims of this study are to implement the linear quadratic regulator (LQR) control and provide noise in the form of random number which will be filtered using a Kalman filter to reduce the noise and achieve a more stable system response. The provision of control and filter methods will be monitored by the user through an easy-to-understand display. The LQR control method will be given to DC motors in order to reduce the error between the output and input. LQR control use six variations of the Q index weighting will be given with an R value of 1. The most optimal Q result is [0.1 0 0; 0 0.1 0; 0 0 0.1] with a rise time is 2.20 seconds and a peak overshoot is 0.09 and the system response results are displayed. in the MATLAB GUI with the addition results after being given a Kalman filter.Keywords – DC motor, LQR, Kalman Filter, MATLAB GUIIntisari – Penggunaan Motor DC menjadi salah satu perangkat elektronik yang digunakan pada bidang robotika, industri bahkan banyak ditemui dalam kehidupan sehari – hari. Penggunaan motor DC yang cukup banyak, di mana user diharapkan dapat memantau kecepatan atau posisi motor DC dan dapat melakukan pemantauan terhadap noise yang terjadi pada sistem. Terdapat banyak penelitian yang telah dilakukan. Penelitian sebelumnya hanya memantau respons sistem tanpa memperhatikan noise yang dihasilkan. Penelitian ini bertujuan untuk menerapkan kendali linear quadratic regulator (LQR) dan memberikan noise berupa random number yang kemudian diberi filter Kalman sehingga noise tersebut dapat dikurangi dan respon sistem menjadi lebih stabil. Pemberian metode kendali dan filter diharapkan dapat dipantau oleh user melalui sebuah tampilan yang mudah dipahami. Metode kendali LQR akan diberikan kepada motor DC untuk mengurangi besarnya kesalahan antara output terhadap input. Pada kendali LQR akan diberikan enam variasi pembobotan indeks Q dengan R bernilai 1 didapatkan hasil Q yang paling optimal ialah [0,1 0 0;0 0,1 0;0 0 0,1] dengan rise time sebesar 2,20 detik dan peak overshoot sebesar 0,09 dan hasil respons sistem ditampilkan pada GUI MATLAB dengan adanya penambahan hasil sistem setelah diberikan filter Kalman.Kata kunci – kecepatan motor DC, LQR, filter Kalman, GUI MATLAB
Airway changes in patients with unilateral cleft lip/palate (UCL/P) after maxillary advancement
Authors: Idso Stefan , Holloway Jared , Patel Pravin , Zhao Linping , Forbes David , Liu Dawei 
Published: June 2023

ABSTRACT

Objectives
To assess the effect on the retropalatal airway (RPA), retroglossal airway (RGA), and total airway (TA) volumes and cephalometrics (SNA, SNB, ANB, PP-SN, Occl-SN, N-A, A-TVL, B-TVL) after maxillary advancement orthognathic surgery in patients with unilateral cleft lip/palate (UCL/P) using cone-beam computed tomography (CBCT).

Materials and Methods
The CBCT scans of 30 patients (13 males and 17 females, 17–20 years old) with UCL/P were evaluated at two time points: preoperative (T1) and postoperative (T2). The interval between T1 and T2 ranged from 9–14 weeks, except for two patients in whom the interval was 24 weeks. Intraexaminer reliability was measured with an intraclass correlation coefficient test. A paired t-test was used to compare the airway and cephalometric measurements between T1 and T2, with a P value of .05 being considered significant.

Results
From T1 to T2, significant increases were found in the volumes of RPA (from 9574 ± 4573 to 10,472 ± 4767, P = .019), RGA (from 9736 ± 5314 to 11,358 ± 6588, P = .019), and TA (from 19,121 ± 8480 to 21,750 ± 10,078, P = .002). In addition, the RGA (from 385 ± 134 to 427 ± 165, P = .020) and TA (from 730 ± 213 to 772 ± 238, P = .016) sagittal area increased significantly. For minimal cross-sectional area (MCA), only the RPA increased significantly (from 173 ± 115 to 272 ± 129, P = .002). All cephalometric changes were statistically significant between T1 and T2 except for SNB.

Conclusions
Maxillary advancement in patients with UCL/P produces statistically significant increases in the retropalatal (volumetric and MCA), retroglossal (volumetric and sagittal), and total (volumetric and sagittal) airways based on data from CBCT imaging.
Monimerkityksistä kielioppia (TULOSSA)
Authors: Niva Heidi 
Published: June 2023

Heidi Nivan suomen kielen alaan kuuluva väitöskirja tarkastettiin Helsingin yliopistossa lauantaina 26.11.2022. Vastaväittäjinä toimi professori emerita Helle Metslang Tarton yliopistosta ja kustoksena oli professori Jaakko Leino.
Heidi Niva: Suomen progressiivirakenne intentioiden ja ennakoinnin ilmaisuissa. Helsinki: Helsingin yliopisto. Luettavissa http://urn.fi/URN:ISBN:978-951-51-8727-7.
Mitigating Knowledge Management Internal and External Risk Factors: A Literature Review of Best Practices
Authors: Dodla Tori Reddy , Jones Laura Ann 
Published: June 2023

Abstract
Used to store, manage, and leverage information, knowledge management systems are becoming increasingly valuable assets within organizations. Organizations must manage knowledge internally (through knowledge risks) and externally (through reputational risks). We define knowledge risks as internal human, technological, and organizational factors, and reputational risks as the effects of knowledge risks and external perils to reputation, credibility, financial status, and future success. An oversight of either risk type can cause significant damage to an organization. This literature review was a means to analyze, categorize, and offer best practices for mitigating risks within a knowledge management system.
Zaedyus pichiy (Desmarest, 1804) is part of the collections of the Šariš Museum in Bardejov (Slovakia)
Authors: Csanády Alexander 
Published: June 2023

Abstract
In this study are presented data of individuals belonging to armadillos (Cingulata, Chlamyphoridae, Zaedyus) from unknow locality of South America (probably from the Chubut region of Argentina). Totally, three voucher specimens and two skulls are in the SMB collection. Specimens presented in this study highlighted the importance of SMB’s collection.