bluuebunny/crossref_metadata_2025_split huggingface dataset:
A toolbox for systematic discovery of stable and transient protein interactors in baker's yeast
Authors: Fenech Emma J , Cohen Nir , Kupervaser Meital , Gazi Zohar , Schuldiner Maya 
Published: January 2023

AbstractIdentification of both stable and transient interactions is essential for understanding protein function and regulation. While assessing stable interactions is more straightforward, capturing transient ones is challenging. In recent years, sophisticated tools have emerged to improve transient interactor discovery, with many harnessing the power of evolved biotin ligases for proximity labelling. However, biotinylation‐based methods have lagged behind in the model eukaryote, Saccharomyces cerevisiae, possibly due to the presence of several abundant, endogenously biotinylated proteins. In this study, we optimised robust biotin‐ligation methodologies in yeast and increased their sensitivity by creating a bespoke technique for downregulating endogenous biotinylation, which we term ABOLISH (Auxin‐induced BiOtin LIgase diminiSHing). We used the endoplasmic reticulum insertase complex (EMC) to demonstrate our approaches and uncover new substrates. To make these tools available for systematic probing of both stable and transient interactions, we generated five full‐genome collections of strains in which every yeast protein is tagged with each of the tested biotinylation machineries, some on the background of the ABOLISH system. This comprehensive toolkit enables functional interactomics of the entire yeast proteome.
Valorar o demoler el patrimonio moderno: el caso del edificio de la ESSO Colombiana S.A. en la ciudad de Bogotá, Colombia
Authors: Largacha Martínez María Olga 
Published: January 2023

Se habla mucho de la urgencia de salvaguardar el patrimonio inmueble de la ciudad de Bogotá, a la vez que se radican planes parciales de renovación para ser avalados por la Secretaría Distrital de Planeación, que en ocasiones entran en contradicción con esta urgencia que busca la respectiva declaratoria como Bien de Interés Cultural (BIC) de dichas edificaciones. Es el caso del Plan Parcial de Renovación Urbana CAR- Universidad Libre, que aparece como con Viabilidad en la página de la Secretaría Distrital de Planeación el cual contiene, dentro de su polígono de intervención, dos edificios imprescindibles para la memoria arquitectónica de Bogotá. Uno de ellos el de Pan American (Edificio Teusacá), el cual afortunadamente ya tiene declaratoria BIC. El otro, el Edificio de la Esso Colombiana, aún no cuenta con esta. Este texto refiere y particulariza este edificio a partir de la revisión de su planimetría y características arquitectónicas en ejercicio investigativo realizado por la autora acerca de Ignacio Martínez Cárdenas y su ejercicio profesional. La investigación parte del siguiente interrogante: ¿Cuál es el argumento para evadir la responsabilidad que tenemos de proteger como conocedores de lo que significa, implica y representa este edificio, en esa localización y con esa clara declaración formal, estética, conceptual y material, manifiesta aún hoy en esta particular edificación?
Codetections of Other Respiratory Viruses Among Children Hospitalized With COVID-19
Authors: Agathis Nickolas T. , Patel Kadam , Milucky Jennifer , Taylor Christopher A. , Whitaker Michael , Pham Huong , Anglin Onika , Chai Shua J. , Alden Nisha B. , Meek James , Anderson Evan J. , Weigel Andy , Kim Sue , Lynfield Ruth , Smelser Chad , Muse Alison , Popham Kevin , Billing Laurie M. , Sutton Melissa , Talbot H. Keipp , George Andrea , McMorrow Meredith , Havers Fiona P. ,   CDC COVID-NET Surveillance Team, Kirley Pam Daily , Kawasaki Breanna , Yousey-Hindes Kimberly , Openo Kyle P. , Nunez Val Tellez , Bilski Kayla , Ropp Susan L. , Barney Grant R. , Bennett Nancy M. , Shiltz Eli , Abdullah Nasreen , Schaffner William , Hill Mary 
Published: January 2023

OBJECTIVES
To assess the clinical impact of respiratory virus codetections among children hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

METHODS
During March 2020 to February 2022, the US coronavirus disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET) identified 4372 children hospitalized with SARS-CoV-2 infection admitted primarily for fever, respiratory illness, or presumed COVID-19. We compared demographics, clinical features, and outcomes between those with and without codetections who had any non-SARS-CoV-2 virus testing. Among a subgroup of 1670 children with complete additional viral testing, we described the association between presence of codetections and severe respiratory illness using age-stratified multivariable logistic regression models.

RESULTS
Among 4372 children hospitalized, 62% had non-SARS-CoV-2 respiratory virus testing, of which 21% had a codetection. Children with codetections were more likely to be &lt;5 years old (yo), receive increased oxygen support, or be admitted to the ICU (P &lt; .001). Among children &lt;5 yo, having any viral codetection (&lt;2 yo: adjusted odds ratio [aOR] 2.1 [95% confidence interval [CI] 1.5–3.0]; 2–4 yo: aOR 1.9 [95% CI 1.2–3.1]) or rhinovirus/enterovirus codetection (&lt;2 yo: aOR 2.4 [95% CI 1.6–3.7]; 2-4: aOR 2.4 [95% CI 1.2–4.6]) was significantly associated with severe illness. Among children &lt;2 yo, respiratory syncytial virus (RSV) codetections were also significantly associated with severe illness (aOR 1.9 [95% CI 1.3–2.9]). No significant associations were seen among children ≥5 yo.

CONCLUSIONS
Respiratory virus codetections, including RSV and rhinovirus/enterovirus, may increase illness severity among children &lt;5 yo hospitalized with SARS-CoV-2 infection.
[Traducción al español] Perfil antropométrico, aeróbico y de potencia muscular de jugadores juveniles de baloncesto costarricenses
Authors: Gutiérrez-Vargas Randall , Ugalde-Ramírez José Alexis , Pino-Ortega José , Trejos-Moya José Andrés , Blanco-Romero Luis , Sánchez-Ureña Braulio , Gutiérrez-Vargas Juan Carlos , Rojas-Valverde Daniel 
Published: January 2023

El objetivo de este estudio fue describir un perfil antropométrico, aeróbico y de potencia muscular de basquetbolistas juveniles costarricenses según sexo, posiciones de juego y categoría de edad. Se evaluaron 99 jugadores juveniles (43 mujeres y 56 hombres; 18 bases, 51 aleros y 30 pívots; 42 categoría U16 y 57 categoría U18) de ocho equipos diferentes. La experiencia deportiva de los jugadores fue de 6.5 ± 3.1 años. Se realizaron las siguientes evaluaciones: altura, peso, índice de masa corporal, masa músculo-esquelética, porcentaje de grasa, prueba de contramovimiento (CMJ) y prueba de Yo-Yo de Recuperación Intermitente Nivel I. Los principales resultados mostraron valores significativamente mayores en hombres que en mujeres en peso, talla, masa músculo-esquelética, distancia recorrida en la prueba Yo-Yo, en el VO2max, altura en el CMJ y en el tiempo de vuelo. El porcentaje de grasa fue mayor en mujeres que en hombres. Los jugadores pívots presentaron significativamente mayor estatura, peso corporal y porcentaje degrasa que las otras posiciones de juego. Los bases y los aleros cubrieron más metros en la prueba Yo-Yo y tuvieron mayor VO2máx que los pívots. Entre las categorías U16 y U18 no se encontraron diferencias significativas en ninguna variable. Modelos de regresión mostraron la influencia del peso, porcentaje de grasa corporal, masa músculo esquelética y la edad sobre el VO2máx y CMJ. Como conclusión, según el sexo y las posiciones de juego de los jugadores, estos indicadores variaron. Además, esta información será útil para procesos de promoción, desarrollo y diseño de entrenamientos de baloncesto juvenil en Costa Rica.
ДОСЛІДЖЕННЯ ВПЛИВУ МУЛЬТИМЕДІЙНИХ ТЕХНОЛОГІЙ НА ЯКІСТЬ ЗАСВОЄННЯ НАВЧАЛЬНОГО КОНТЕНТУ
Authors: Іванова Л. В. , Джабраілов Д. В. 
Published: January 2023

В статті проведено аналіз використання мультимедійних технологій у освітньому процесі, представлені результати аналізу навчального контенту створеного з застосуванням мультимедійних засобів. Визначені основні групи навчального та довідникового мультимедійного контенту. Проведено аналіз мультимедійних засобів та визначена їх частка у навчальних курсах відомих освітніх платформ. Представлена методика проведення експериментального дослідження щодо визначення впливу мультимедійних засобів навчального контенту на якість засвоєння навчального контенту. Визначені етапи проведення експериментального дослідження щодо впливу мультимедійних засобів подання навчального контенту на якість засвоєння навчального матеріалу. Для проведення дослідження розроблена діагностувальна програма. Модулі програми дозволяють провести всі етапи експериментального дослідження впливу мультимедійних технологій на якість сприйняття навчального матеріалу здобувачами освіти. Представлені результати експериментального дослідження проведені серед здобувачів освіти коледжу. Представлена модель взаємодії учасників експериментального дослідження. Надано рекомендації щодо використання методики для створення якісного навчального контенту для певних категорій здобувачів освіти.
Role of Medical Insurance in Reducing Place‐based Health Disparities: Functional Disability in Rural Appalachia
Authors: Patrick Julie Hicks , Pullen Carly E. , Ibrahim‐Bacha Kareem , Spencer S. Mindi 
Published: January 2023

AbstractRural Appalachia, including the entire state of West Virginia, is characterized by high health disparities. Such place‐based health disparities contribute to disability across the lifespan and may exacerbate morbidity and disability in late life. Thus, examinations of the contributors to morbidity and disability at mid‐and late‐life are needed to inform policies and programs.Using the most recent data from the Centers for Disease Control and Prevention's (CDC) Behavioral Risk Factor Surveillance System (BRFSS), we examine some of the social determinants of health (e.g., age, gender, education, income) as predictors of access to health care and functional ability among 4,867 adults living in West Virginia. Access to health care was indexed by three variables, including whether one had financial barriers to medical care, the number of personal medical care professionals one saw, and the recency of wellness exams. Functional ability was indexed using items assessing difficulty with dressing, climbing stairs, and doing errands. The model fit the data well for the entire sample, X2 (DF = 29, N = 4867) = 411.30, p < .001, CFI = .94, RMSEA = .052. Post hoc models with the age groups fit well, although some differences in specific paths emerged. Our results suggest that policies and programs that increase medical access for current middle‐aged and older adults might decrease functional ability. Moreover, as the younger adults age into midlife, they enter with lower economic and educational resources, further exacerbating their lack of access to health care and increasing disability in future generations of West Virginians.
Patient‐Provider Relationships in an All‐Inclusive Specialized Geriatric Program: A Longitudinal Qualitative Study among Older Foreign‐Born Latinos with Multimorbidities
Authors: Bravo Rosana L. , Gutiérrez Ángela , Levy‐Storms Lené F. 
Published: January 2023

AbstractObjectiveThe quality of patient‐provider relationships (PPR) is directly related to delivering patient‐centered care and improved healthcare outcomes (e.g., adherence to medical treatments) and differs across types of patients to the point of health disparities. PPRs are further complicated when factoring in multiple chronic health conditions, language barriers, and limited time. This qualitative longitudinal study explored the perceived acquiring of high‐quality PPR among older foreign‐born Latinos over time.MethodsWe recruited 13 patients with multi‐morbidities from nine Program of All‐Inclusive Care for the Elderly (PACE) centers. Researchers conducted three rounds of in‐depth interviews in Spanish (N=39 interviews) over 13 months. The first interviews were conducted face‐to‐face and lasted one hour on average. The second and third were conducted over the phone and ranged from 60 to 90 minutes. Data were analyzed using line‐by‐line in vivo coding, identifying categories, and themes.ResultsPatients reported their perceived PPR as a continuum across time, establishing three hypothesized hierarchical developmental levels to the PPR: the good doctor, the doctor of trust, and the advocate. The layers of levels built upon each other. The first level, the good doctor, was the most superficial as it focused on the physicians' technical expertise. The second level, the doctor of trust demonstrated trustworthy characteristics over time. The third level, the advocate, embodied all that a person of trust was plus an additional advocacy dimension.ConclusionUnique study characteristics allowed for an exploration of PPRs. Findings elucidate factors (e.g., expertise, trust, advocacy) that contribute to the development of strong PPRs. To enhance PPRs, strategies should be considered to develop trust and advocate for patients' needs.
COVID-19 DIAGNOSIS EXPERT SYSTEM WITH CERTAINTY FACTOR METHOD
Authors: Arifah Novia Nur , Wibowo Jati Sasongko 
Published: January 2023

Covid-19 is a new type of virus that is currently a pandemic in almost all countries. The limitations of experts for diagnosis and recommending rapid action to patients who are diagnosed positively, as well as the limitations of the expert area in the environment wh ere the Covid-19 outbreak occurred. This expert system aims as an early diagnosis system for Covid-19 so that patients can receive treatment immediately, and help stop the wider spread of the virus. Using predetermined parameters and there is also a system that can later make it easier for users to find out the diagnosis of Covid-19 caused by the coronavirus. The method used for this expert system research is Certainty Factor (CF). This method aims to showed how much the confidence value is based on the clinical parameters given by MYCI. The advantage of the Certainty Factor method is that it can be measured something that is certain or uncertain. And to maintain accuracy, Certainty Factor can only process two data. The Expert System uses the Certainty Factor (CF) method to diagnose Covid-19 disease, starting with the collection of symptom data and giving confidence values by the expert on each symptom, then the symptom data input stage from the user and the system will calculate based on the Certainty Factor rule, multiplying the weight value namely user CF and expert CF, combining the results of the multiplication of each symptom, so that a percentage of confidence is obtained as the final diagnosis result. After calculating the accuracy test of the 3 rule system with 99% positive Covid-19 results, 48% most likely Covid-19 and 29% negative Covid-19.
El turismo como motor de crecimiento económico en Colombia (2000-2019)
Authors: ALONSO RODRÍGUEZ JOHAN RICARDO 
Published: January 2023

En los últimos años el gobierno colombiano y el Ministerio de Comercio, Industria y Turismo, junto a su entidad adscrita ProColombia, están apostando por el turismo como el sector prometedor para el desarrollo de las exportaciones de servicios en Colombia, conseguir un saldo positivo en la balanza comercial y mejorar las tasas de crecimiento económico del país. Actualmente, Colombia es reconocido por los atractivos turísticos de sus sitios de playa, pero esto no es todo el potencial que tiene el país, ya que también cuenta con un “turismo de naturaleza” representado por las reservas nacionales naturales y su extensa biodiversidad de especies, que permiten ver a Colombia como una promesa del turismo en el mundo y con suficientes argumentos para que este sector se convierta en el motor de su crecimiento económico. En el presente artículo se analiza a la industria del turismo colombiano desde el impacto que este genera a la economía nacional y a sus cuentas internacionales y tras la aplicación y análisis del modelo del Diamante de Porter (1999) se determina que el gran potencial del sector en Colombia depende de los niveles de competitividad del país y, naturalmente, del sector, por lo que es vital reconsiderar el turismo colombiano planteando segmentos y productos alternativos como el turismo comunitario de manera que se persigan objetivos tanto sociales como económicos compatibles con los intereses generales de las comunidades locales anfitrionas.
Palabras clave: Turismo; Colombia; Diamante de Porter, Crecimiento económico; Turismo comunitario
Polemics and Popularisation: Aspects of Kant’s Early Reception in Russia
Authors:   Immanuel Kant Baltic Federal University, Dmitrieva Nina A. 
Published: January 2023

The reception of Kant’s philosophy in Russia at the beginning of the 19th cen­tury was focused mainly on religious and ethical issues, although it did not ex­clude theoretical and cognitive questions. The search for textbooks that would adequately and at the same time comprehensibly introduce students and the edu­cated public to the basic ideas of the Kantian philosophical system led two professors at Kazan University, Alexander S. Loubkin and Petr S. Kondyrev, to the textbook on philosophy for beginners by Friedrich Wilhelm Daniel Snell, the German Kantian philosopher, pedagogue and populariser. The work they did in preparing the Russian edition of that textbook was not confined to translation, although the translation of the philosophical text itself required scrupulous termi­nological work, since there were as yet no equivalents for many philosophical terms in Russian. Each of the translators provided parts of the textbook with their own explanations and additions, with the parts on moral philosophy and philosophy of religion attracting the most interest and polemical objections. Loubkin’s criticism of Snell and thus in most cases of Kant concerns such key concepts and provisions of Kantian practical philosophy as practical reason, the end of moral acts, the distinction between thing and person, the categorical imperative, the feeling of respect for the moral law and others. The real stum­bling block for Loubkin was Kant’s solution to the problem of the relation be­tween religion and morality and his choice of a foundation for morality. Loubkin suggests that the moral is grounded in religion and proposes as the criterion of morality the correspondence of an act to the Divine Will.
Normation of the Priest in Modern Russia: the Genesis of the Process and the Main Stages
Authors:   St. Tikhon’s Orthodox University, Lyutko Eugene I. 
Published: January 2023

This article examines the problem of the development of the narrative about the norm in relation to the priest, using the example of the context of the modern Rus­sia. The concept of the norm is key for the modern state and society that is emerg­ing in the modern era, and despite the fact that this concept itself is not found in domestic sources, the value of the corresponding concept has been consis­tently growing since the 17th century. The author proposes to see the genesis of the process of normation of the Orthodox priest in the era that followed the Schism, when for the first time a functional reading of the liturgical activity of the clergy is revealed as an activity capable to ensure the piety of the people. The discovery of the priest as the subject of normation activates the development of discursive resources capable of supporting this process. At the first stage, it is a collective concept of the clergy, allowing to fix the subject of the norm itself. The hitch of the figure of a priest with the key modern ethical concept – “duty” – expands the possibilities for developing a norm. Finally, the discipline of “pas­toral theology”, which undergoes the swift development in the second half of the 19th century, becomes the predominant “place” for the normation of the priest – a process that reached its apex during the counter-reforms of Alexander III.
Asociality of the Albert Schweitzer’s Ethics: a Fact or a Myth?
Authors:   Independent researcher, Gorbunov Svyatoslav S. 
Published: January 2023

This report completes our series of short notes on Albert Schweitzer’s ethical concept. It aims to consider the asocial nature of Schweitzer’s ethical concept and worldview. The scientific novelty of the research is determined by the analy­sis of an assumption that “individualism and immoralism” of Schweitzer’s ethics act as insurmountable obstacles to its social reception. The results obtained con­sist in the discussion of the conceptual idea of a society as an ethical person, i.e. an ethical-oriented formation. At the same time, we consider whether the de­velopment of the society from the individual to the general through an individual ethically motivated self-development of each person is possible and necessary.
Culture as the Subject Matter and Horizon of Philosophical Thought in Post-Soviet Russia (St. Petersburg Approaches)
Authors:   Saint-Petersburg State University, Osipov Igor D. , Rybas Aleksandr E. ,   Saint-Petersburg State University
Published: January 2023

The article considers the emergence, variants of justification and critique of cul­turology, a new science which appeared in Russia in the 1990s. The main atten­tion is given to the analysis of discussions of St. Petersburg philosophers around culturology, its problem field and methodology. The positions of the leading cul­turologists of St. Petersburg M.S. Kagan, Yu.N. Solonin, E.G. Sokolov, and oth­ers are discussed. The authors are of the opinion that culturology was the most notable and interesting phenomenon of the post-Soviet philosophy; therefore, the study of its history provides a better understanding of the essence of the era as a whole. The authors argue that the post-Soviet period in the development of Russian philosophy can now be considered completed, and this sets appropri­ate tasks for historians of Russian thought, among which the task of understand­ing the causes of the exhaustion of the ideological-theoretical and creative poten­tial of post-Soviet thought is the most important. Equally important is the task of comprehending the positive content of post-Soviet philosophy, because it is likely to determine the prospects and problems of Russian philosophical culture in future. The article shows that, since the establishment of culturology, a critical attitude towards its project has prevailed among St. Petersburg philosophers and culturologists, nevertheless there have been made attempts to justify culturology and to prove its importance for Russian culture. The conclusion is made that the post-Soviet stage of the history of Russian philosophy, despite its characteristic “Europeanization”, has managed to become an organic link in the progressive development of Russian philosophical culture.