bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic responses of tea (Camellia sinensis L.) to the insecticide thiamethoxam
Authors: Jiao Weiting , Zhang Ping , Cui Chuanjian , Yan Min , Li Qing X. , Tang Yongfeng , Zhang Nan , Wang Xinyi , Hou Ruyan , Hua Rimao 
Published: May 2023

BackgroundThiamethoxam (TMX) is insecticidal, but also can trigger physiological and metabolic reactions of plant cycles. The objective of this work was to evaluate the physiological and metabolic effect of TMX on tea plants and its potential benefits.ResultsIn this study, dose of TMX (0.09, 0.135 and 0.18 kg a.i./ha) were tested. Except for peroxidase (POD) and glutathione S‐transferase (GST), chlorophyll, carotenoid, catalase (CAT) and malondialdehyde (MDA) were significantly affected compared with the controls. The CAT activity was increased by 3.38, 1.71, 2.91 times, respectively, under three doses of TMX treatment. The metabolic response between TMX treatment and control groups on the third day was compared using a widely targeted metabolomics. A total of 97 different metabolites were identified, including benzenoids, flavonoids, lipids and lipid‐like molecules, organic acids and derivatives, organic nitrogen compounds, organic oxygen compounds, organoheterocyclic compounds, phenylpropanoids and polyketides, and others. Those metabolites were mapped on the perturbed metabolic pathways. The results demonstrated that the most perturbation occurred in flavone and flavonol biosynthesis. The beneficial secondary metabolites luteolin and kaempferol were upregulated 1.46 and 1.31 times respectively, which protect plants from biotic and abiotic stresses. Molecular docking models suggest interactions between TMX and flavonoid 3‐O‐glucosyltransferase.ConclusionThiamethoxam spray positively promoted the physiological and metabolic response of tea plants. And this work also provided the useful information of TMX metabolism in tea plants as well as rational application of insecticides. © 2023 Society of Chemical Industry.
Comparison of Blueberry and Dandelion Aqueous Extracts in the Synthesis of Gold and Silver Nanostructures, and Their Applications as Anti‐Pseudomonas aeruginosa Agent
Authors: Dilek Tepe Hafize , Şeymanur Aktaş B. S. , Çeter Talip , Yazgan İdris 
Published: May 2023

AbstractWe performed a comparative study using aqueous extracts of dandelion flowers and blueberry fruits to synthesize gold‐ (Au) and silver‐ (Ag) nanostructures (NSs). The blueberry extracts gave nanowire and spherical AuNSs upon changing the ratio of the extracts to Au3+precursor while altering the ratio for the dandelion extracts resulted in formation of only anisotropic AuNSs. Similar results were obtained during the AgNSs, where the dandelion extracts resulted in formation of quasi‐spherical AgNSs at the tested ratio (extract/AgNO3 ratio) while altering the ratio for the blueberry extracts resulted in nanorod and nanoplates formation. We argued that this could be from dominancy of a lone compound or a group of compounds and tested this claim by introducing chrysin and amino acid mixtures to the blueberry extracts. Altering the added chrysin amount triggered nanoplate and spherical AuNSs formation while alteration in amino acid mixture content did not change the morphology, and spherical AuNSs were obtained. The antibacterial studies revealed the AgNSs are toxic to Pseudomonas aeruginosa with 8 μg/mL MBC (minimum bactericidal concentration) and 3 μg/mL values for the blueberry and dandelion extracts synthesized AgNSs while penicillin/streptomycin sulfate mixture carrying Dandelion‐AuNSs gave 12‐times lower MBC value in comparison to free penicillin/streptomycin sulfate mixture.
Cosmological de Sitter Solutions of the Semiclassical Einstein Equation
Authors: Gottschalk Hanno , Rothe Nicolai R. , Siemssen Daniel 
Published: May 2023

AbstractExponentially expanding space–times play a central role in contemporary cosmology, most importantly in the theory of inflation and in the dark energy driven expansion in the late universe. In this work, we give a complete list of de Sitter solutions of the semiclassical Einstein equation (SCE), where classical gravity is coupled to the expected value of a renormalized stress–energy tensor of a free quantum field in the Bunch–Davies state. To achieve this, we explicitly determine the stress–energy tensor associated with the Bunch–Davies state using the recently proposed “moment approach” on the cosmological coordinate patch of de Sitter space. From the energy component of the SCE, we thus obtain an analytic consistency equation for the model’s parameters which has to be fulfilled by solutions to the SCE. Using this equation, we then investigate the number of solutions and the structure of the solution set in dependency on the coupling parameter of the quantum field to the scalar curvature and renormalization constants using analytic arguments in combination with numerical evidence. We also identify parameter sets where multiple expansion rates separated by several orders of magnitude are possible. Potentially for such parameter settings, a fast (semi-stable) expansion in the early universe could be compatible with a late-time “Dark Energy-like” behavior of the universe.
Regional Gravity Model of Greece Based on Satellite, Marine and Terrestrial Data
Authors: Dilalos Spyridon , Alexopoulos John D. 
Published: May 2023

AbstractGreece is a country structured by land, several islands and sea. A regional gravity model of such a country demands the involvement of several types of gravity data in order to cover all its territory. In this paper, we present the development of a regional combined gravity model of Greece and its surrounding area, by integrating terrestrial, marine (shipborne and altimetry-derived gravity data) and satellite data (GOCE and GRACE data). These kinds of data, especially the terrestrial and marine ones, have passed quality and validation control since they were collected from different organizations, which means that they probably have been acquired and processed with different parameters and formulas. Following that, their integration was accomplished with the application of the least-squares collocation (LSC). Therefore, a newly combined regional gravity model of Greece and its surrounding areas has been developed. This gravity model can be valuable for regional geological and geophysical studies of Greece, since it provides homogeneously the distribution of Complete Bouguer anomaly (CBA) all over Greece, with updated gravity data and in good agreement with the initial gravity datasets that have been used.
Cannabis self-administration in the human laboratory: a scoping review of ad libitum studies
Authors: Xiao Ke Bin , Grennell Erin , Ngoy Anthony , George Tony P. , Le Foll Bernard , Hendershot Christian S. , Sloan Matthew E. 
Published: May 2023

AbstractCannabis self-administration studies may be helpful for identifying factors that influence cannabis consumption and subjective response to cannabis. Additionally, these paradigms could be useful for testing novel pharmacotherapies for cannabis use disorder. This scoping review aims to summarize the findings from existing ad libitum cannabis self-administration studies to determine what has been learned from these studies as well as their limitations. We examined studies that specifically examined cannabis smoking, focusing on subjective response and self-administration behavior (e.g., smoking topography). A systematic search was conducted using PubMed and Embase from inception to October 22, 2022. Our search strategy identified 26 studies (total N = 662, 79% male) that met our eligibility criteria. We found that tetrahydrocannabinol (THC) concentration significantly affected subjective response to cannabis in some but not all studies. In general, cannabis self-administration tended to be most intense at the beginning of the laboratory session and decreased in later parts of the session. There was limited data on cannabis self-administration in adults older than 55. Data on external validity and test-retest reliability were also limited. Addressing these limitations in future ad libitum cannabis self-administration studies could lead to more valid and generalizable paradigms, which in turn could be used to improve our understanding of cannabis use patterns and to help guide medication development for cannabis use disorder.
Exploring Blastocystis genetic diversity in rural schoolchildren from Colombia using next-generation amplicon sequencing reveals significant associations between contact with animals and infection risk
Authors: Hernández Paula C. , Maloney Jenny G. , Molokin Aleksey , George Nadja S. , Morales Liliana , Chaparro-Olaya Jacqueline , Santin Monica 
Published: May 2023

AbstractBlastocystis is a common intestinal protist with a global distribution in humans and many other animals. Yet, the status of Blastocystis as a pathogen, the risk factors associated with its transmission, and its zoonotic potential remain ill-defined. Here, we explored subtype (ST) diversity and potential risk factors for Blastocystis infection in 98 children from Apulo, Colombia. Samples were screened for Blastocystis via PCR, and ST identification was performed through next-generation amplicon sequencing (NGS). Associations between the presence of Blastocystis and individual STs and sociodemographic variables were assessed via logistic regression analyses. Seventy-one samples (72.4%) were Blastocystis-positive, and NGS revealed the presence of five STs (ST1-ST5). ST1, ST2, and ST3 were common and observed in nearly equal proportions (~ 40%), while samples with ST4 (1.4%) and ST5 (5.6%) were comparatively rare. The presence of mixed STs in the same sample was also common (28.2%). Comparisons among children within the same household identified that shared ST profiles were common, but diversity within family units was also observed. Logistic regression analyses returned significant associations between the presence of Blastocystis, individual subtypes, or mixed subtypes for several variables. Intriguingly, the presence of animals was one of the most common significant associations. Taken together, these data represent an important step forward in understanding both the potential routes and risk factors that may influence Blastocystis transmission and will be useful in shaping future studies which seek to clarify the relationships between STs, pathogenicity, and zoonotic transmission.
Complete seasonal surveillance of Greylag Goose (Anser anser) foraging behavior on dairy grassland and the effect of limited lethal scaring
Authors: Aarseth Jo Jorem 
Published: May 2023

AbstractIn northern Norway, an increasing population of Greylag Geese (Anser anser) forages considerably on dairy grassland and can eat up to 60% of the grass (dry matter mass) on a field if allowed to eat undisturbed throughout the growing season. In this study, the seasonal foraging behavior of Greylag Geese on diary grassland was continuously monitored with game cameras from late April to the end of August to be able to pinpoint effective preventive measures to manage, control, and prevent this crop damage. Limited, but regular, lethal scaring was conducted on some fields to reveal the preventive effect of this measure. Foraging from Greylag Geese in a rangeland area was also monitored, and a complete dataset of seasonal foraging behavior of this species is presented here. Greylag Geese foraging on the fields reaches a top between 04:00 and 08:00 h am, all season. Energy and digestibility of the field grass (timothy) did not reveal any correlation with grazing patterns. Greylag Geese do not visit the fields during molting; however, they may visit fields with their chicks to forage. Lethal scaring completely removes visits from Greylag Geese on the fields where this is conducted, while foraging continues if geese are given undisturbed access. In the rangeland area foraging seems to be even and continuous throughout the season, but significantly lower. In the end of June and late July/early August, there is a peak in visits and number of geese per visit on the fields. Preventive and effective measures against crop damage from Greylag Geese must therefore at least be initiated during late June and early August, and between 04:00 and 08:00 am.
A non-ergodic spectral acceleration ground motion model for California developed with random vibration theory
Authors: Lavrentiadis Grigorios , Abrahamson Norman A. 
Published: May 2023

AbstractA new approach for creating a non-ergodic pseudo-spectral acceleration (PSA) ground-motion model (GMM) is presented, which accounts for the magnitude dependence of the non-ergodic effects. In this approach, the average PSA scaling is controlled by an ergodic PSA GMM, and the non-ergodic effects are captured with non-ergodic PSA factors, which are the adjustment that needs to be applied to an ergodic PSA GMM to incorporate the non-ergodic effects. The non-ergodic PSA factors are based on the effective amplitude spectrum (EAS) non-ergodic effects and are converted to PSA through Random Vibration Theory (RVT). The advantage of this approach is that it better captures the non-ergodic source, path, and site effects through small-magnitude earthquakes. Due to the linear properties of the Fourier Transform, the EAS non-ergodic effects of the small events can be applied directly to the large magnitude events. This is not the case for PSA, as response spectra are controlled by a range of frequencies, making PSA non-ergodic effects dependent on the spectral shape, which in turn is magnitude-dependent. Two PSA non-ergodic GMMs are derived using the ASK14 (Abrahamson et al. in Earthq Spectra 30:1025–1055, 2014) and CY14 (Chiou and Youngs in Earthq Spectra 30:1117–1153, 2014) GMMs as backbone models, respectively. The non-ergodic EAS effects are estimated with the LAK21 (Lavrentiadis et al. in Bull Earthq Eng ) GMM. The RVT calculations are performed with the V75 (Vanmarcke in ASCE Mech Eng Mech Division 98:425–446, 1972) peak factor model, the $$D_{a0.05-0.85}$$

D

a
0.05
-
0.85

estimate of AS96 (Abrahamson and Silva in Apendix A: empirical ground motion models, description and validation of the stochastic ground motion model. Tech. rep.,. Brookhaven National Laboratory, New York) for the ground-motion duration, and BT15 (Boore and Thompson in Bull Seismol Soc Am 105:1029–1041, 2015) oscillator-duration model. The California subset of the NGAWest2 database (Ancheta et al. in Earthq Spectra 30:989–1005, 2014) is used to fit both models. The total aleatory standard deviation of each of the two non-ergodic PSA GMMs is approximately $$25\%$$

25
%

smaller than the total aleatory standard deviation of the corresponding ergodic PSA GMMs. This reduction has a significant impact on hazard calculations at large return periods. In remote areas, far from stations and past events, the reduction of aleatory variability is accompanied by an increase in epistemic uncertainty.
The mixed subtype has a worse prognosis than other histological subtypes: a retrospective analysis of 217 patients with metaplastic breast cancer
Authors: Hu Jiayue , Lang Ronggang , Zhao Weipeng , Jia Yongsheng , Tong Zhongsheng , Shi Yehui 
Published: May 2023

Abstract
Objective
Metaplastic breast cancer (MpBC) is an aggressive subtype of all breast cancer. We aimed to investigate the clinicopathological features, treatments and prognoses of MpBC patients.

Methods
We collected the data from MpBC patients diagnosed at Tianjin Medical University Cancer Hospital from 2010 to 2017. Kaplan Meier curves and Cox regression model were used to evaluating clinical outcomes and prognostic factors. After removing baseline differences by propensity score matching (PSM), we analyzed the prognosis between MpBC patients and invasive ductal carcinomas of no special type (IDC-NST) patients.

Results
A total of 217 MpBC patients were subsumed. Of all histological subtypes, 45.1% were mixed subtypes, followed by with mesenchymal differentiation (27.2%), pure squamous (15.2%) and pure spindle (12.4%) subtypes. 69.6% of MpBC were triple-negative, 25.3% and 6.5% were HR-positive and HER2-positive. MpBC patients had worse survival compared to IDC-NST patients, with 5-year RFS of 73.8 and 83.6% (HR = 1.177 95%CI (1.171–2.676) P = 0.0068), and 5-year BCSS of 79.0% and 89.7% (HR = 2.187 95%CI (1.357–3.523) P = 0.0013). In the multivariate COX model, AJCC stage, mixed subtype and chemotherapy were independent prognostic factors. Mixed MpBC is more aggressive than pure and with heterologous mesenchymal differentiation subtypes. And whether squamous or spindle MpBC, mixed forms have shorter outcomes than pure forms.

Conclusions
MpBCs are associated with poorer prognoses than IDC-NSTs. They are heterogeneous with different clinicopathological features and clinical outcomes between histological subtypes. Pure and with heterologous mesenchymal differentiation subtypes have more survival benefits than the mixed subtype.
Secular orbital dynamics of the innermost exoplanet of the $$\upsilon $$-Andromedæ system
Authors: Mastroianni Rita , Locatelli Ugo 
Published: May 2023

AbstractWe introduce a quasi-periodic restricted Hamiltonian to describe the secular motion of a small-mass planet in a multi-planetary system. In particular, we refer to the motion of $$\upsilon $$
υ
-And $$\textbf{b}$$
b
which is the innermost planet among those discovered in the extrasolar system orbiting around the $$\upsilon $$
υ
-Andromedæ A star. We preassign the orbits of the Super-Jupiter exoplanets $$\upsilon $$
υ
-And $$\textbf{c}$$
c
and $$\upsilon $$
υ
-And $$\textbf{d}$$
d
in a stable configuration. The Fourier decompositions of their secular motions are reconstructed by using the well-known technique of the (so-called) frequency analysis and are injected in the equations describing the orbital dynamics of $$\upsilon $$
υ
-And $$\textbf{b}$$
b
under the gravitational effects exerted by those two external exoplanets (that are expected to be major ones in such an extrasolar system). Therefore, we end up with a Hamiltonian model having $$2+3/2$$

2
+
3
/
2

degrees of freedom; its validity is confirmed by the comparison with several numerical integrations of the complete four-body problem. Furthermore, the model is enriched by taking into account also the effects due to the relativistic corrections on the secular motion of the innermost exoplanet. We focus on the problem of the stability of $$\upsilon $$
υ
-And $$\textbf{b}$$
b
as a function of the parameters that mostly impact on its orbit, that are the initial values of its inclination and the longitude of its node (as they are measured with respect to the plane of the sky). In particular, we study the evolution of its eccentricity, which is crucial to exclude orbital configurations with high probability of (quasi)collision with the central star in the long-time evolution of the system. Moreover, we also introduce a normal form approach, that is based on the complete average of our restricted model with respect to the angles describing the secular motions of the major exoplanets. Therefore, our Hamiltonian model is further reduced to a system with 2 degrees of freedom, which is integrable because it admits a constant of motion that is related to the total angular momentum. This allows us to very quickly preselect the domains of stability for $$\upsilon $$
υ
-And $$\textbf{b}$$
b
, with respect to the set of the initial orbital configurations that are compatible with the observations.
An observational study of the cause and frequency of prescription rework in community pharmacies
Authors: Olden Frank , Dalton Kieran 
Published: May 2023

Abstract
Background
When prescriptions are being processed in pharmacies, ‘rework’ is a phenomenon where an activity occurs that requires the return to a prior procedural step in the process for correction. To date, little is known regarding rework prevalence in community pharmacies or how this might be minimised.

Aim
To evaluate the cause and frequency of prescription rework in community pharmacies.

Method
A list of reworks was designed for community pharmacists to self-record prescription rework instances and causes in their workplace across a two-week period. Community pharmacists in Ireland were recruited via convenience sampling and snowballing. Descriptive statistics were used to assess rework frequency according to the various causes, as well as the pharmacist and pharmacy characteristics.

Results
Eight pharmacists participated, recording 325 reworks across 92.9% of the 65 study days (mean 5 reworks/day). The pharmacists’ mean ranged from 1.82 to 15 reworks/day. Pharmacists and pharmacy technicians alone or together were involved in 72.3% of reworks. The three most common rework categories were involving labelling errors (22.8%), prepared prescriptions which necessitated opening and repackaging (15.1%), and medication owings to patients (13.9%).

Conclusion
This study reveals that prescription rework occurs frequently in community pharmacies and has provided an indication of some of the main causes. These findings demonstrate areas where pharmacy staff can address rework and should aid the development of approaches to minimise rework in future – thus decreasing workload and facilitating more time for community pharmacy staff to focus on providing patient care.
Energy flow analysis of grass carp pond system based on Ecopath model
Authors: Xiao Shuwen , Liu Xingguo , Zhou Runfeng , Zhao Yuxi , Sun Zhaoyun 
Published: May 2023

Abstract
Grass carp (Ctenopharyngodon idellus) is the most productive freshwater fish in China, but its traditional aquaculture model still has problems, such as poor water quality and frequent diseases. We have taken monoculture and 80:20 polyculture grass carp ponds as the research object and used EwE software to build the Ecopath model of two ponds. We analyzed and compared the characteristics of ecological structure and energy flow in two ponds. The result showed the highest effective trophic level in the polyculture pond that was higher than that in the monoculture pond, and fish in polyculture had higher EE values which showed the production of fish in polyculture contributed more to the energy conversion efficiency of the ecosystem. Flows into detritus were the largest component of TST both in the two ponds, which accounted for 49.34% and 50.37%. And the average transfer efficiency in monoculture was 13.07%, while that in polyculture was 15.6%. The ascendency/total development capacity (A/TDC) and overhead/total development capacity (O/TDC) were 0.35 and 0.65 both in the two ponds, respectively, which indicated that both systems had a strong anti-perturbation ability, but the stability could be improved. Finn’s cycling index (FCI) in polyculture was higher and showed that the polyculture pond was more mature and stable. Unused energy of functional groups will flow to detritus, and that in the monoculture pond was higher, the energy of C. idellus that flowed to detritus in monoculture was 48.17% higher than that in polyculture; unused energy of bacteria and phytoplankton were also high. The result showed that polyculture could improve energy utilization, increase transfer efficiency, and raise the stability of the ecosystem. Grass carp ponds still need to be improved in the aspects of mixed species and energy consumption. It is necessary to improve the ecological and economic benefits of grass carp ponds by optimizing the aquaculture structure and adjusting the aquaculture proportion.