bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimoto's thyroiditis: a clinical and molecular docking study
Authors: ASLAN Elif Sibel , GÜR Savaş 
Published: June 2023

Aims: Our approach in this study is to investigate the collective effect of various parameters, including vitamin B12 (B12), vitamin D (Vit-D), folic acid, and iron deficiency, on Hashimoto's thyroiditis (HT) disease. This differs from existing literature that has examined these parameters individually.
Methods: The study evaluated age, gender, thyroid stimulating hormone (TSH), free-T4 (FT4), free-T3 (FT3), Vit-D levels, as well as autoantibodies against thyroid peroxidase (anti-TPO) and anti-tyroglobulin iron (anti-TG) levels, ferritin, B12, and folic acid parameters in a total of 30 HT patients and 37 non-HT patients. These parameters were assessed by analyzing the patients' routine blood test results using automated analysis methods.
Results: A negative correlation was found between the blood, Vit-D level and anti-TG (as the vit-D value increases, the anti-TG decreases) (r=-0.417; p=0.001; p
Evaluation of pituitary gland dimensions by age and gender in healthy individuals in the Turkish population
Authors: YALTIRIK BİLGİN Ezel , ÜNAL Özkan 
Published: June 2023

Aim: Evaluating pituitary gland dimensions in varying age ranges and genders is essential for determining average values in MRI examinations. Therefore, the main objective of our study is to create normative data for pituitary gland size in the Turkish population.
Material and Method: Anteroposterior (AP), transverse (TR), and craniocaudal (CC) dimensions of the pituitary glands of 200 patients over 18 years of age, who underwent Brain MRI examination in our centre between November 2022 and March 2023, did not have any known endocrine disease, did not use hormonal therapy, were not pregnant or breastfeeding, had no history of radiotherapy or chemotherapy were measured from their sagittal and axial MRI sequences. The Kolmogorov-Smirnov test was used for normality analyses. The Mann-Whitney U test was used to compare the non-normally distributed numerical variables between the two groups. Spearman correlation was applied to determine the relationship between age and pituitary gland measurement values.
Results: Anteroposterior and craniocaudal measurements of the pituitary gland of female patients included in the study were significantly higher than males (p=0.011 and p
Increased acute invasive fungal rhinosinusitis in COVID-19 patients
Authors: BULUT ÇÖBDEN Serap , ÖZCAN İbrahim , KAYA Altan , KANTEKİN Yunus , ALTIPARMAK Serkan , ALKAYA Mustafa , BAYRAM Ali , SAV Hafize 
Published: June 2023

Aim: Acute invasive fungal rhinosinusitis (AIFRS) is a rare infection of the nose and paranasal sinuses that can be fatal. Infection may lead to tissue infarction, necrosis, and thrombosis and rapidly spread intracranially. The aim of this study is to highlight the increasing cases of AIFRS after covid-19 and to investigate the parameters affecting mortality.
Material and Method: Total 11 patients diagnosed with AIFRS after COVID-19 were included in this study. Patient age, gender, comorbid diseases, initial symptoms, time between COVID-19 diagnosis and AIFRS diagnosis, intensive care hospitalization history, medical treatments, surgical findings, antifungal treatment, fungal species grown in culture, mortality, and the relationships of these parameters with mortality were also evaluated.
Results: A total of 11 patients diagnosed with AIFRS after COVID-19 were included in the study. Among these patients, 81.8% were male, 18. 2% were female, and ages ranged from 57 years to 89 years. The mean time between COVID-19 infection and development of IFRS in patients was 26.09±18.04 days. The initial symptoms in 45.45% of the patients were unilateral periorbital edema, vision loss, and total ophthalmoplegia. The surgical approach was purely endoscopic in all patients. In our study, the mortality rate was 72.7% in COVID-19 related AIFRS patients.
Conclusion: As a result, in our study, we found an increase in AIFRS incidence and mortality due to the systemic effects of COVID 19 and the treatments used for it. AIFRS should be suspected when a patient presents acute sinusitis symptoms after COVID-19 infection.
Bibliometric analysis of the 50 most cited articles on artificial intelligence for lung cancer imaging
Authors: SERİNDERE Mehmet 
Published: June 2023

Aim: The use of machine learning has now become widespread in lung cancer. However, the research trend is still unclear. This study aimed to analyze the most influential publications on artificial intelligence (AI) for lung cancer.
Material and Method: A comprehensive PubMed and SCImago Journal and Country Rank (SJR) search was performed. The 50 most cited articles were recorded according to the citation numbers, the country and institute of articles, the name and metrics of the publishing journal, the year of publication, and the content of the articles.
Results: The citation numbers ranged from 24 to 628. Annual citations per article was between 1.47 and 104.6. The USA was the country with the most publications (n=22) followed by The Netherlands (n=9) and Peoples R China (n=5). The journal and institution that highly contributed to the 50 most cited articles were Radiology (n=5) and Harvard Medical School (n=5), respectively.
Conclusion: The importance of deep learning and AI in lung cancer imaging is increasing day by day. In this study, a detailed bibliometric analysis of the literature on AI in lung cancer imaging was performed. In addition, this bibliometric analysis informs researchers about current influential papers in this field, the characteristics of these studies, and potential future trends in the rapidly evolving field of AI in lung cancer screening.
Follicular Thyroid Adenoma with Papillary Architecture
Authors: Carnate Jose 
Published: June 2023

A 23-year-old woman underwent left thyroid lobectomy and isthmusectomy for a 2 cm diameter firm mass on the left side of the neck that was also visualized on ultrasonography. The specimen consisted of a 22-gram thyroid gland composed of the left lobe, isthmus and a pyramidal lobe. Cut section of the left lobe showed a 3.5 cm diameter solitary, discrete and encapsulated mass with a tan lobulated and solid cut surface. The rest of the thyroid tissues had red-brown meaty cut surfaces.
Microscopic section shows a follicular-patterned proliferation enclosed by a thin fibrous capsule with frequent Sanderson polster-like papillary excrescences. (Figures 1 and 2) Both the follicular and the papillary structures are lined by cuboidal to columnar follicular epithelial cells that had ample eosinophilic to pale cytoplasm and uniformly sized, minimally enlarged, generally round, and monolayered nuclei without nuclear grooving, folds, pseudoinclusions, and chromatin clearing. There are no mitotic figures seen. Some of the papillary structures have delicate vascular cores. (Figure 3) There are no psammoma bodies noted. The follicles contain variable amounts of pale eosinophilic colloid ranging from colloid-poor crowded follicles to those with ample colloid that have frequent peripheral scalloping. (Figure 4) Exhaustive sections failed to disclose capsular or vascular invasion. Based on the microscopic features, a diagnosis of follicular adenoma with papillary architecture was rendered.
Estimation of antimicrobial effect of non-thermal microwave plasma jet in model experiment
Authors: Petrukhina D. I. , Kharlamov V. A. , Gorbatov S. A. , Medzhidov I. M. , Shishko V. I. , Tkhorik O. V. 
Published: June 2023

Relevance. The plasma treatment of ready-to-eat foods the potential use to increase a storage time and a food safety. On the first step seems important to evaluate the bactericidal effect of a non-thermal (non-equilibrium) plasma on a natural association bacteria isolated from the food.Methods. The non-thermal plasma source based on an argon plasma jet in a microwave (streamer) discharge at atmospheric pressure was used. Lactobacillus culture isolated from a walnut in the natural association and the vegetative form was treated. Sowing was carried on Petri dishes with Endoʼs agar. The exposure time is 60 s, 180 s and 360 s. The distance from the plasma jet source’s nozzle to the Endoʼs agar surface was 30 mm. The diameter of the growth inhibition zone of Lactobacillus on the dense nutrient medium was determined.Results. The round transparent Endo’s agar area — the zone of growth inactivation of colony-forming units in bacterial lawn of Lactobacillus after exposure to argon plasma jet was registered. After counting colony-forming units, a decrease in the number of Lactobacillus colonies grown after a 360-second exposure was found. At a 60-second exposure, no significant decrease in the number of grown colony-forming units was observed. The bactericidal effect is noticeable after a 180-second exposure to the plasma jet. With an increase in the exposure time to 360 s, the sterilization area on the surface of the agar in the Petri dish increased. The maximum diameter of the Lactobacillus growth inactivation zone did not exceed the diameter of the nozzle of the plasma jet source (36 mm). Under the influence of plasma, the color of the Endo agar changed in the zone of direct exposure to the plasma jet.
The second volume of «Pomology»
Authors: Gruner L. A. 
Published: June 2023

Information is provided about the new book of the second volume of «Pomology», prepared at VNIISPK with the participation of breeders and cultivars of leading horticultural institutions in Russia. The book was published under the general editorship of Academician of the Russian Academy of Sciences E.N. Sedov and Doctor of Agricultural Sciences E.A. Dolmatov, republished with additions at the end of 2022 at the expense of the Russian Academy of Sciences. In the updated volume of «Pomology» «Pear. Quince» additionally introduced 75 new pear varieties included in the State Register of Breeding Achievements approved for use by the Russian Federation over the past 15 years, and the best promising varieties of this crop undergoing state testing. About 70 varieties of pears are excluded from the State Register and the book (for various reasons). During this time, 8 new varieties of quince were created and included in the book, 12 were excluded. In total, the volume contains descriptions of 195 varieties of pears, 21 varieties of quinces and 7 clonal rootstocks (quinces) for pears.The structure of the second volume of «Pomology» is described, in which there is an introductory part consisting of several sections and reporting on the importance of pear and quince culture for the national economy, the centers of origin and classification of the genus Pyrus L., the initial types and assortment of pears, the peculiarities of individual development of fruit plants, pomological terminology used in the description of pear varieties and quinces, the economic and biological characteristics of these crops.Descriptions of varieties are built according to a single scheme, providing a detailed description of all morphological parts of plants, biochemical composition, taste and commodity qualities of fruits, indication of the most important economic advantages and disadvantages of cultivars. All descriptions of cultivars are accompanied by author’s color photos of the fruits. The Volume contains 387 pages. The book can be used as a reference by anyone interested in horticulture, including scientists, undergraduates and graduate students, as well as gardeners. Edition — 300 copies.
Milk productivity of first-calf heifers depending on the line and age of the first insemination
Authors: Gorelik O. V. , Gorelik A. S. , Fedoseeva N. A. , Temerbayeva M. V. 
Published: June 2023

Relevance. One of the key types of raw materials that ensure the food security of Russian citizens is milk. To obtain it, dairy cattle are used, including Holstein, created by absorbing the breeding stock of domestic black-and-white cattle by bulls of the Holstein breed. The study of economically useful qualities of a new genetic formation of dairy cattle in the Middle Urals zone is of both scientific and practical interest.Methods. The aim of the work is to evaluate the milk productivity of Holstein cattle depending on the age of the first insemination, taking into account the linear origin.Results. As a result of the research, certain features were established that, in our opinion, are associated precisely with the origin (depending on the age of insemination, the animals are divided into 4 subgroups). So, in the group of heifers of the line Reflection Sovering 198998, the same trend of change in milk productivity depending on the age of the first insemination, as well as the average for the herd. The first heifers with the age of the first insemination up to 14 months had the highest productivity (p ≤ 0.05 between the 1st and 3rd groups in favor of the 1st). In heifers of the Vis Back Idial line, on the contrary, the highest milk yields were in animals inseminated for the first time at the age of more than 18 months. They have the highest milk yields compared to cows from other lines. The superiority ranged from 700 (Reflection Sovering line) to 2275 kg (Montwick Chieftain line) or 7.6–24.9% for the highest milk yields (р ≤ 0.05–0.01). Among the animals of the line Montvik Chieftain 95679 had the highest milk yield of first-calf heifers inseminated at the age of 14 months. They outperformed cows with other periods of insemination by 886–891 kg (р ≤ 0.05).
The influence of seeding rates on the yield of pea grain in the conditions of the Pre-Ural steppe of the Republic of Bashkortostan
Authors: Davletov F. A. , Gainullina K. P. 
Published: June 2023

Relevance. Leguminous crops are the main source of vegetable protein in the world, among which pea is the most common in Russia. Among agrotechnical practices, the seeding rate plays an important role in forming the yield of this crop and obtaining high and stable grain yields. The purpose of the work is to study the influence of various seed sowing rates on the yield of pea varieties in the Republic of Bashkortostan. The experiments were carried out in the conditions of the Pre-Ural steppe subzone in 2017–2020. Pea varieties Chishminskiy 95, Chishminskiy 229, Pamyati Khangilʼdina, Pamyati Popova served as the material for the study.Methods. Sowing qualities of seeds were determined in accordance with GOST 12038-84, GOST 10968-88, GOST 12042-80, GOST 12036-85. Field assessments, phenological observations were carried out according to the methodology of the State cultivar testing of agricultural crops.Results. In our experiments, different conditions of moisture supply, illumination and nutrition of pea plants, due to different seeding rates, had a significant impact on the grain yield in the studied varieties. The increase in the number of plants preserved for harvesting, which depends on their survival and the number of seedlings, was accompanied by an increase in yield. It has been established that pea varieties Chishminskiy 95, Chishminskiy 229, Pamyati Khangilʼdina and Pamyati Popova form the highest and most stable grain yields at early sowing dates with a seeding rate of 1.2 million pieces of germinating seeds per 1 ha. With a decrease in the seeding rate, the weediness of crops increases, and with an increase in the seeding rate, pea plants experience a lack of moisture and nutrients, which leads to a decrease in yield by 0.4–1.0 c/ha.
STRATEGI HOME INDUSTRI KONVEKSI DALAM MENINGKATKAN PENDAPATAN RUMAH TANGGA MASYARAKAT KOTA BINJAI (STUDI KASUS ABU BAKAR KONVEKSI MENCIRIM BINJAI TIMUR)
Authors: Imsar Imsar 
Published: June 2023

This study aims to determine how the potential and empowerment role of the convection home industry in increasing community household income, and to determine the SWOT analysis of strategies used to increase household income in Binjai city. The background of this research is that in the 2020-2024 RPJMN, one of the macro targets is to improve the processing industry, one of the agendas is to strengthen quality economic defense by encouraging MSMEs. This research method is descriptive qualitative accompanied by a SWOT analysis. The analysis technique used is descriptive method and SWOT analysis, the formulation of a strategy that is processed from the weight of the identification results of the SWOT factor. The results of the calculation of the SWOT analysis of the total IFAS are higher than the total EFAS. The strategy to increase the business of the research object is in cell I Growth is namely the Backward integration or Forward integration strategy. In order to increase its business strength or competitive position, Burn Ash Convection must make efforts to minimize costs and inefficient operations to control the quality and distribution of products.
IMPLEMENTASI MANAJEMEN SYARIAH PADA YAYASAN SAHABAT YATIM INDONESIA CABANG MEDAN
Authors: Toni Hidayat  
Published: June 2023

Ajaran Islam mencakup dua dimensi pokok, yaitu dimensi vertical dan dimensi horizontal . Kualitas tertinggi dari ketaatan yang bersifat vertikal adalah takwa, sementara kualitas tertinggi dari ketaatan yang bersifat horizontal adalah berlaku adil. Konsep syariah yang diambil dari hukum Al Quran sebagai dasar pengelolaan unsur- unsur manajemen agar dapat menggapai target yang dituju. Manajemen adalah suatu proses bekerja sama dengan dan melalui lainnya untuk mencapai tujuan organisasi dengan efektif dan secara efisien menggunakan sumberdaya yang terbatas di lingkungan yang berubah-ubah. Manajemen syariah adalah perilaku yang terkait dengan nilai-nilai keimanan dan ketauhidan. Yayasan Sahabat Yatim Indonesia adalah lembaga yang dikelola berdasarkan dengan dasar-dasar syari’ah, atau dengan kata lain, pengelolaan Yayasan Sahabat Yatim Indonesia harus berdasarkan nilai-nilai serta prinsip dan konsep syari’ah Penelitian ini merupakan penelitian deskriptif kualitatif, penulis ingin mengetahui implementasi manajemen syariah Yayasan Sahabat Yatim Indonesia Cabang Medan dalam menjalankan operasinalnya dalam mewujudkan masa depan yatim dan dhuafa menjadi insan yang madani
PENGARUH KUALITAS PELAYANAN TERHADAP KEPUASAN MASYARAKAT PADA PELAYANAN PEMBUATAN SKCK DI POLRESTABES MEDAN
Authors: Zahwa Miftahul Ulfa Ritonga  
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh antara kualitas pelayanan terhadap kepuasan masyarakat pada pelayanan pembuatan SKCK di Polrestabes Medan. Populasi dalam penelitian ini yaitu jumlah masyarakat yang megurus SKCK pada bulan Mei - Oktober 2020 dengan penentuan sampel menggunakan rumus slovin sehingga dapat disimpulkan menjadi 100 responden. Teknik analisis data yang penulis gunakan dalam penelitian ini yaitu deskriptif kuantitatif. Pengumpulan data yang digunakan adalah dengan menggunakan kuesioner yang diberikan kepada responden. Data diolah menggunakan SPSS 22.0 for windows. Teknik analisis data yang digunakan adalah Analisi Regresi Linear Sederhana, dengan Y = 2,845 + 0.098X, artinya Kualitas Pelayanan mempunyai pengaruh yang signifikan terhadap variabel Kepuasan Masyarakat.
Akta Kuasa Ditandatangani tidak dihadapan Notaris sebagai Dasar Balik Nama Sertifikat Hak Milik
Authors: Lubis Tegar Abma Putra , Gozali Djoni S , Qamariyanti Yulia 
Published: June 2023

Tujuan dari penelitian ini ialah bagaimanakah pertanggungjawaban Notaris terhadap akta kuasa tidak ditandatangani dihadapan notaris sebagai dasar balik nama sertifikat hak milik berdasarkan Putusan Mahkamah Agung Nomor 1615 K/PDT/2020 dan bagaimana akibat hukum terhadap Notaris yang dinyatakan melakukan perbuatan melawan hukum berdasarkan Putusan Mahkamah Agung Nomor 1615 K/PDT/2020 Penelitian ini menggunakan jenis penelitian yuridis normatif, Tipe Penelitian ini terhadap asas-asas hukum (studi dogmatic atau doctrinal researah), Sifat penelitian yang spesifikasi penelitiannya adalah deskriptif, pendekatan yang digunakan adalah pendekatan undang-undang (statute approach), pendekatan kasus (case approach), serta pendekatan konseptual (conceptual approach), sumber bahan hukum sekunder, Teknik pengumpulan bahan hukum yang digunakan dalam penelitian ini adalah studi kepustakaan (library research), Teknik analisis yang digunakan adalah teknik analisis kualitatif. Kesimpulan dalam penilitian ini yaitu Pertanggungjawaban Notaris terhadap akta yang dibuatnya melekat selamanya dalam akta tersebut sehingga apabila akta tidak ditandatangani dihadapan notaris maka akan mengakibatkan akta tersebut menjadi akta dibawah tangan dan dapat dibatalkan berdasarkan keputusan pengadilan yang berkekuatan hukum tetap dan akibat pembatalan terhadap akta notariil akan mengakibatkan pembatalan terhadap perbuatan hukum berdasarkan akta notariil tersebut. Dan Akibat hukum terhadap Notaris yang dinyatakan melakukan perbuatan melawan hukum berdasarkan Putusan Mahkamah Agung Nomor 1615 K/PDT/2020 maka Notaris tersebut secara hukum dapat dijatuhi sanksi secara pidana dengan membuat akta palsu serta apabila diajukan ke Majelis Pengawas Notaris maka notaris tersebut dapat dikenakan sanksi secara administratif karena telah terbukti melakukan perbuatan melawan hukum sehingga membuktikan notaris tersebut tidak membuat akta sebagaimana yang diatur didalam Undang-Undang Nomor 2 Tahun 2014 tentang perubahan atas Undang-Undang Nomor 30 Tahun 2004 tentang Jabatan Notaris.
Nuevos retos en la creación y protección empresarial y marcaria en el metaverso
Authors: Alarcón Lora Andrés Antonio , Meza Herrera Andrea Carolina , Mestra Gómez Tatiana Marcela 
Published: June 2023

El metaverso es una nueva realidad virtual en el que la sociedad está comenzando a desarrollarse, junto con ella las empresas que ingresan al metaverso en busca de mantenerse en los últimos estándares virtuales, creando economías sin límites físicos y posibilidades ilimitadas. Dicho marco, refiere el problema central de la creación de nuevos bienes digitales para ser utilizados en estos, generando la duda de cómo serán protegidos estos bienes y hasta dónde llega la protección de cada país sobre estas marcas.
De dicho alcance, se encarga este trabajo de investigación; haciendo especial énfasis en la necesidad de nuevas regulaciones a través de las entidades privadas que crean las realidades del metaverso en busca de una protección de la propiedad industrial. Así, se aborda el problema de un marco legal del metaverso donde basados en normas ya existentes y otras a desarrollar se regulen estas actividades con el fin de proteger a las empresas y a los usuarios recalcando la importancia que se hagan bajo miras internacionales.
Para tal fin, esta investigación se apoya en un método jurídico de enfoque cualitativo proclive a estudios bibliográficos de fuentes oficiales; todo esto, en pro de proponer unos primeros acercamientos a la cuestión.
El monopolio de los privilegios: conflictos entre comerciantes vecinos y residentes en Cartagena de Indias, 1774
Authors: Pinzón Narváez Meliza Vanesa 
Published: June 2023

Pertenecer a un importante grupo institucional o familiar en la sociedad colonial era vital, así como ejercer un cargo en el poder e incluso tener riquezas para obtener ciertos privilegios. El “privilegium”, en su carácter de derecho atribuido a un grupo limitado de destinatarios o a una situación específica, reflejaba la estructura fundamental del antiguo régimen: la estructura de la diferencia.
La monarquía española otorgó gracias particulares a la mayoría de las corporaciones y le dio a otros grupos socialmente fuertes un estatuto jurídico especial. Para el caso de los comerciantes, estos dispusieron de una institución mercantil propia como lo fueron los consulados, los cuales eran regulados por sus propias ordenanzas.