bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of remnant cholesterol with hypertension, type 2 diabetes, and their coexistence: the mediating role of inflammation-related indicators
Authors: Wu Yuxuan , Wei Qinfei , Li Husheng , Yang Han , Wu Yuying , Yu Yiming , Chen Qiansi , He Baochang , Chen Fa 
Published: September 2023

Abstract
Purpose
Cholesterol metabolism is a risk factor for cardiovascular disease, and recent studies have shown that cholesterol metabolism poses a residual risk of cardiovascular disease even when conventional lipid risk factors are in the optimal range. The association between remnant cholesterol (RC) and cardiovascular disease has been demonstrated; however, its association with hypertension, type 2 diabetes mellitus (T2DM), and the concomitance of the two diseases requires further study. This study aimed to evaluate the association of RC with hypertension, T2DM, and both in a large sample of the U.S. population, and to further explore the potential mechanisms involved.

Methods
This cross-sectional study used data from the 2005—2018 cycles of the National Health and Nutrition Examination Survey (N = 17,749). Univariable and multivariable logistic regression analyses were performed to explore the relationships of RC with hypertension, T2DM, and both comorbidities. A restricted cubic spline regression model was used to reveal the dose effect. Mediation analyses were performed to explore the potential mediating roles of inflammation-related indicators in these associations.

Results
Of the 17,749 participants included (mean [SD] age: 41.57 [0.23] years; women: 8983 (50.6%), men: 8766 (49.4%)), the prevalence of hypertension, T2DM, and their co-occurrence was 32.6%, 16.1%, and 11.0%, respectively. Higher RC concentrations were associated with an increased risk of hypertension, T2DM, and their co-occurrence (adjusted odds ratios for per unit increase in RC were 1.068, 2.259, and 2.362, and 95% confidence intervals were 1.063–1.073, 1.797–2.838, and 1.834–3.041, respectively), with a linear dose–response relationship. Even when conventional lipids were present at normal levels, positive associations were observed. Inflammation-related indicators (leukocytes, lymphocytes, monocytes, and neutrophils) partially mediated these associations. Among these, leukocytes had the greatest mediating effect (10.8%, 14.5%, and 14.0%, respectively).

Conclusion
The results of this study provide evidence that RC is associated with the risk of hypertension, T2DM, and their co-occurrence, possibly mediated by an inflammatory response.
Prevalence, one-year-incidence and predictors of carcinoid heart disease
Authors: Mattig Isabel , Franke Maximilian Richard , Pschowski Rene , Brand Anna , Stangl Karl , Knebel Fabian , Dreger Henryk 
Published: September 2023

Abstract
Background
Carcinoid heart disease (CHD) caused by neuroendocrine tumours (NET) is associated with an increased morbidity and mortality due to valvular dysfunction and right sided heart failure. The present study aimed to assess the prevalence and one-year-incidence of CHD in NET patients. Tumour characteristics, laboratory measurements, and echocardiographic findings were evaluated to identify predictors of CHD manifestation.

Methods
The study was an investigator-initiated, monocentric, prospective trial. Patients with NET without previously diagnosed CHD were included and underwent comprehensive gastroenterological and oncological diagnostics. Echocardiographic examinations were performed at baseline and after one year.

Results
Forty-seven NET patients were enrolled into the study, 64% of them showed clinical features of a carcinoid syndrome (CS). Three patients presented with CHD at baseline and three patients developed cardiac involvement during the follow-up period corresponding to a prevalence of 6% at baseline and an incidence of 6.8% within one year. Hydroxyindoleacetic acid (5-HIAA) was identified to predict the occurrence of CHD (OR, 1.004; 95% CI, 1.001–1.006 for increase of 5-HIAA), while chromogranin A (CgA), and Kiel antigen 67 (Ki 67%) had no predictive value. Six patients with CHD at twelve-month follow-up revealed a tendency for larger right heart diameters and increased values of myocardial performance index (MPEI) at baseline compared to NET patients.

Conclusion
The prevalence at baseline and one-year-incidence of CHD was 6–7%. 5-HIAA was identified as the only marker which predict the development of CHD.

Graphical Abstract
Development of an Elliptical Perturbation System that provides unexpected perturbations during elliptical walking (the EPES system)
Authors: Sade Shoval , Pickholz Hodaya , Melzer Itshak , Shapiro Amir 
Published: September 2023

Abstract
Background
‘Perturbation-based balance training’ (PBBT) is a training method that was developed to improve balance reactive responses to unexpected balance loss. This training method is more effective in reducing fall rates than traditional balance training methods. Many PBBTs are performed during standing or treadmill walking which targeted specifically step reactive responses, we however, aimed to develop and build a mechatronic system that can provide unexpected perturbation during elliptical walking the Elliptical Perturbation System (the EPES system), with the aim of improving specifically the trunk and upper limbs balance reactive control.

Methods
This paper describes the development, and building of the EPES system, using a stationary Elliptical Exercise device, which allows training of trunk and upper limbs balance reactive responses in older adults.

Results
The EPES system provides 3-dimensional small, controlled, and unpredictable sudden perturbations during stationary elliptical walking. We developed software that can identify a trainee’s trunk and arms reactive balance responses using a stereo camera. After identifying an effective trunk and arms reactive balance response, the software controls the EPES system motors to return the system to its horizontal baseline position after the perturbation. The system thus provides closed-loop feedback for a person’s counterbalancing trunk and arm responses, helping to implement implicit motor learning for the trainee. The pilot results show that the EPES software can successfully identify balance reactive responses among participants who are exposed to a sudden unexpected perturbation during elliptical walking on the EPES system.

Conclusions
EPES trigger reactive balance responses involving counter-rotation action of body segments and simultaneously evoke arms, and trunk reactive response, thus reactive training effects should be expected.
Bibliometric and visualized analysis of arthroscopic treatment of acromioclavicular joint injury
Authors: Zhang Jian , Li Mingjun , Yang Yuxia , Liu Wenkang , Meng Xiangji , Fei Wenyong , Wang Jingcheng 
Published: September 2023

Abstract
Background
Since arthroscopy was discovered to treat acromioclavicular joint injury, people have had great interest and attention to this beautiful and minimally invasive operation, and related research has been increasing worldwide. At present, there is no bibliometric and visualized analysis in this field. The purpose of this study is to explore the research hotspots and trends of arthroscopic treatment of acromioclavicular joint injury through bibliometric and visualized analysis and look forward to the future development direction of clinical practice.

Methods
The publications on arthroscopic treatment of acromioclavicular joint injury diseases from its establishment to April 2023 were obtained from the Web of Science (WOS) Core Collection database. CiteSpace, VOSviewer, Scimago graphica and Origin were used for bibliometric and visualized analysis.

Results
This study included a total of 330 publications. The number of publications tends to increase every year. The USA has the most significant number of publications and citations. Imhoff AB is the most relevant scholar with the largest number of publications in this field, and the scholar with the highest citation and average citations is Mazzocca AD. Tech Univ Munich, Rush University and Charite are the three institutions with the greatest contribution. Tech Univ Munich, Rush University and Charite are the three institutions with the greatest contribution. In addition, “Arthroscopy-the Journal of Arthroscopic and Related Surgery” and “American Journal of Sports Medicine” are the institutions with the most significant number of publications and average citations, respectively. The most common keywords are “acromioclavicular joint dislocation,” “arthroscopic resection,” “arthroscopic reconstruction” and “coracoclavicular ligament.”

Conclusion
The number of publications shows a steady upward trend as a whole. However, there is still a lack of cooperation among countries, institutions and scholars around the world, so various countries, institutions and scholars need to strengthen academic exchanges and expand the field of cooperation, so as to promote further research and development in related fields. However, minimally invasive methods such as arthroscopy are still the hotspots and frontiers in the treatment of acromioclavicular joint injury in the future.
Management of anomalous origin of right coronary artery from left coronary sinus
Authors: Mangel Tobin , Divya Aabha , De Silva Ravi 
Published: September 2023

AbstractAberrant origin of coronary artery is a rare congenital anomaly associated with increased risk of myocardial ischemia and sudden death, with the highest risk lesions being those arising from the opposite sinus of Valsalva. We report a case with an aberrant right coronary artery arising superior to the left coronary cusp, with a slit-like ostium, having an inter-arterial and intramural course through the aortic root, that underwent repositioning of the right coronary artery. We believe such cases warrant surgical correction and reimplantation is a safe, effective and reproducible technique.
Usage of chitosan from Hermetia illucens as a preservative for fresh Prunus species fruits: a preliminary analysis
Authors: Triunfo Micaela , Tafi Elena , Guarnieri Anna , Ianniciello Dolores , Scieuzo Carmen , Salvia Rosanna , Hahn Thomas , Zibek Susanne , Falabella Patrizia 
Published: September 2023

Abstract
Background
Fruit and vegetables are highly perishable. In an era where reducing food waste is absolutely essential, packaging is important for maintaining the postharvest quality of these fresh products. Research is working to reduce the use of synthetic materials, not safe for the environment and human health. In this perspective, chitosan emerges as a viable solution for this purpose, as it is biodegradable, biocompatible and also safe for food application. The growing interest in using insects as a source of chitin has allowed for increased exploitation of insect-based waste products to recover valuable materials, such as biopolymers. The black soldier fly (Hermetia illucens L.) is the most widely reared species in Europe for feed production and waste management.

Results
In this work, fresh mature apricots (Prunus armeniaca L.), nectarines (Prunus persica vulgaris Mill.) and yellow peaches (Prunus persica var. laevis Gray) were coated with 0.5% and 1% chitosan from the pupal exuviae of Hermetia illucens, applied by spraying and stored at room temperature or 4 °C until they decay. Then, to validate the effectiveness of chitosan as a polymer for fruit preservation, several parameters including pH, TSS and weight loss were evaluated.

Conclusions
The results showed that chitosan derived from the black soldier fly is as effective as or better than the commercially available crustacean chitosan in maintaining more stable some storage parameters in fresh apricots, nectarines and peaches. Thus, insects, especially Hermetia illucens, are confirmed as a viable alternative source of the polymer.

Graphical Abstract
Management of left traumatic diaphragmatic hernia complicated by traumatic Stanford type B aortic dissection
Authors: Matsubayashi Yuta , Takanashi Yusuke , Sekihara Keigo , Hayakawa Takamitsu , Mizuno Kiyomichi , Kawase Akikazu , Sato Masanori , Shiiya Norihiko , Funai Kazuhito 
Published: September 2023

Abstract
Background
Traumatic diaphragmatic hernias are frequently associated with multiple organ injuries caused by high-energy trauma. Herein, we report a case of left traumatic diaphragmatic hernia complicated by traumatic Stanford type B aortic dissection, in which we considered surgical strategies for the timing and approach of diaphragmatic hernia repair.

Case presentation
A 65-year-old man was transported to our hospital following a traffic accident. He was diagnosed with left traumatic diaphragmatic hernia, traumatic Stanford type B aortic dissection, multiple fractures of the left ribs, hemothorax, and pulmonary contusion. Because acute surgery for hernia repair might exacerbate aortic dissection, we initiated conservative treatment for aortic dissection. Respiratory status and ischemia of the herniated organs were monitored carefully. On the day 6, when the aortic dissection was considered stable, we performed diaphragmatic hernia repair. A large surgical field secured by thoracolaparotomy enabled safe surgical techniques for visualization of the aortic wall. Postoperatively, there was no diaphragmatic hernia recurrence, and the aortic dissection remained stable with conservative treatment.

Conclusions
In traumatic diaphragmatic hernia complicated by traumatic Stanford type B aortic dissection, elective surgery via the trans-thoracoabdominal approach may be safe after stabilization of aortic dissection, provided the respiratory condition can be kept stable.
Tucatinib and Trastuzumab for Previously Treated Human Epidermal Growth Factor Receptor 2–Positive Metastatic Biliary Tract Cancer (SGNTUC-019): A Phase II Basket Study
Authors: Nakamura Yoshiaki , Mizuno Nobumasa , Sunakawa Yu , Canon Jean-Luc , Galsky Matthew D. , Hamilton Erika , Hayashi Hidetoshi , Jerusalem Guy , Kim Seung Tae , Lee Keun-Wook , Kankeu Fonkoua Lionel Aurelien , Monk Bradley J. , Nguyen Danny , Oh Do-Youn , Okines Alicia , O'Malley David M. , Pohlmann Paula , Reck Martin , Shin Sang Joon , Sudo Kazuki , Takahashi Shunji , Van Marcke Cedric , Yu Evan Y. , Groisberg Roman , Ramos Jorge , Tan Sherry , Stinchcombe Thomas E. , Bekaii-Saab Tanios 
Published: September 2023

PURPOSE To evaluate the efficacy and safety of tucatinib and trastuzumab in patients with previously treated human epidermal growth factor receptor 2–positive (HER2+) metastatic biliary tract cancer (mBTC). METHODS SGNTUC-019 (ClinicalTrials.gov identifier: NCT04579380 ) is an open-label phase II basket study evaluating the efficacy and safety of tucatinib and trastuzumab in patients with HER2-altered solid tumors. In the biliary tract cancer cohort, patients had previously treated HER2 overexpressing or amplified (HER2+) tumors (identified with local testing) with no prior HER2-directed therapy. The primary end point was confirmed objective response rate (cORR) per investigator assessment. Patients were treated on a 21-day cycle with tucatinib (300 mg orally twice daily) and trastuzumab (8 mg/kg intravenously followed by 6 mg/kg every 3 weeks). RESULTS Thirty patients were enrolled. As of data cutoff (January 30, 2023), the median duration of follow-up was 10.8 months. The cORR was 46.7% (90% CI, 30.8 to 63.0), with a disease control rate of 76.7% (90% CI, 60.6 to 88.5). The median duration of response and progression-free survival were 6.0 months (90% CI, 5.5 to 6.9) and 5.5 months (90% CI, 3.9 to 8.1), respectively. At data cutoff, 15 patients (50.0%) had died, and the estimated 12-month overall survival rate was 53.6% (90% CI, 36.8 to 67.8). The two most common treatment-emergent adverse events (TEAEs) were pyrexia (43.3%) and diarrhea (40.0%). Grade ≥3 TEAEs were reported in 18 patients (60.0%), with the most common being cholangitis, decreased appetite, and nausea (all 10.0%), which were generally not treatment related. TEAEs led to treatment regimen discontinuation in one patient, and there were no deaths due to TEAEs. CONCLUSION Tucatinib combined with trastuzumab had clinically significant antitumor activity and was well tolerated in patients with previously treated HER2+ mBTC.
Active smelling in the American cockroach
Authors: Hoffmann Antoine , Couzin-Fuchs Einat 
Published: September 2023

ABSTRACT
Motion plays an essential role in sensory acquisition. From changing the position in which information can be acquired to fine-scale probing and active sensing, animals actively control the way they interact with the environment. In olfaction, movement impacts the time and location of odour sampling as well as the flow of odour molecules around the olfactory organs. Employing a detailed spatiotemporal analysis, we investigated how insect antennae interact with the olfactory environment in a species with a well-studied olfactory system – the American cockroach. Cockroaches were tested in a wind-tunnel setup during the presentation of odours with different attractivity levels: colony extract, butanol and linalool. Our analysis revealed significant changes in antennal kinematics when odours were presented, including a shift towards the stream position, an increase in vertical movement and high-frequency local oscillations. Nevertheless, the antennal shifting occurred predominantly in a single antenna while the overall range covered by both antennae was maintained throughout. These findings hold true for both static and moving stimuli and were more pronounced for attractive odours. Furthermore, we found that upon odour encounter, there was an increase in the occurrence of high-frequency antennal sweeps and vertical strokes, which were shown to impact the olfactory environment's statistics directly. Our study lays out a tractable system for exploring the tight coupling between sensing and movement, in which antennal sweeps, in parallel to mammalian sniffing, are actively involved in facilitating odour capture and transport, generating odour intermittency in environments with low air movement where cockroaches dwell.
Prevalence and intensity of soil-transmitted helminth infections in Uganda: Results from population-based prevalence surveys in five districts
Authors: Tinkitina Benjamin , Beinamaryo Prudence , Adriko Moses , Nabatte Betty , Arinaitwe Moses , Mubangizi Alfred , Emerson Paul , Dhakal Sanjaya , Sullivan Kristin M. 
Published: September 2023

Background
Soil-transmitted helminth (STH) infections are caused by roundworms (Ascaris lumbricoides), whipworms (Trichuris trichiura), and hookworms (Necator americanus and Ancylostoma duodenale). In Uganda, baseline surveys conducted during the late 1990s and early 2000s suggested STH infections were common, with prevalence >50% among surveyed schoolchildren. In 2003, a national program was launched with mass preventative chemotherapy (PC) and health education for children 1–14 years old. Little evidence is available to show the impact of national deworming.

Methods
We conducted population-based, cross-sectional household surveys in five districts (Buikwe, Kassanda, Kiryandongo, Kisoro, and Rubanda) in March and May 2022. Our primary objective was to estimate STH prevalence by species due to infections of any intensity and infections of moderate-to-heavy intensity among preschool-aged children (PSAC, 1–4 years old), school-aged children (SAC, 5–14 years old), and women of reproductive age (WRA, 15–49 years old). Laboratory technicians used duplicate Kato-Katz microscopy to determine fecal egg count.

Results
Overall, 3,352 PSAC; 3,884 SAC; and 1,226 WRA provided stool samples. The prevalence of any infection remained high in Kisoro at or above ~50% within all risk groups. In other districts, the prevalence of any infection ranged from approximately 5 to 16% among PSAC, 6 to 23% among SAC, and 12 to 19% among WRA. Moderate-to-heavy intensity infection prevalence was highest in Kisoro (~15–26%), followed by Rubanda (<5%), and was ≤1% in other districts. A. lumbricoides and T. trichiura infections were largely confined to Kisoro and Rubanda, whereas hookworm was most common in other districts.

Conclusions
The STH prevalence has decreased markedly in three districts in Uganda. Based on our findings, the national deworming program should consider decreasing PC distribution frequency in these districts per the World Health Organization guidelines. Efforts are needed to understand why the Kisoro and Rubanda districts did not demonstrate similar gains.
Early death after a diagnosis of metastatic solid cancer–raising awareness and identifying risk factors from the SEER database
Authors: Globus Opher , Sagie Shira , Lavine Noy , Barchana Daniel Itshak , Urban Damien 
Published: September 2023

Background
Cancer death rates are declining, in part due to smoking cessation, better detection and new treatments; nevertheless, a large fraction of metastatic cancer patients die soon after diagnosis. Few studies and interventions focus on these patients. Our study aims to characterize early mortality in a wide range of metastatic solid tumors.

Methods
We retrieved data on adult patients diagnosed with pathologically confirmed de- novo metastatic solid tumors between the years 2004–2016 from the Surveillance, Epidemiology, and End Results database (SEER). Our primary outcome was cancer specific early death rate (defined as death within two months of diagnosis). Additional data extracted included socio-demographical data, tumor primary, sites of metastases, and cause of death.

Results
109,207 (20.8%) patients died of de-novo metastatic cancer within two months of diagnosis. The highest rates of early death were found in hepatic (36%), pancreato-biliary (31%) and lung (25%) primaries. Factors associated with early death included primary site, liver, and brain metastases, increasing age, and lower income. Cancer was the cause of death in 92.1% of all early deaths. Two-month mortality rates have moderately improved during the study period (from 22.4% in 2004 to 18.8% in 2016).

Conclusion
A fifth of de-novo metastatic cancer patients die soon after diagnosis, with little improvement over the last decade. Further research is required to better classify and identify patients at risk for early mortality, which patients might benefit from faster diagnostic tracks, and which might avoid invasive and futile diagnostic procedures.
Regimes of Desire: Young Gay Men, Media, and Masculinity in Tokyo, Thomas Baudinette (2021)
Authors: Coates Jamie 
Published: September 2023

Review of: Regimes of Desire: Young Gay Men, Media, and Masculinity in Tokyo, Thomas Baudinette (2021)
Ann Arbor, MI: University of Michigan Press, 262 pp.,
ISBN 978-0-47203-861-9, p/bk, £27.95