bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arqueología experimental, algo más que un juego
Authors: Baena Javier 
Published: June 2023

No me cabe la menor duda que a estas alturas del desarrollo de la investigación en la Prehistoria, la Arqueología Experimental es aceptada por todos como una fuente esencial de información sobre actividades del pasado, tan importante como la propia etnoarqueología, la palinología, la paleontología o cualquier otra disciplina ligada a la Prehistoria. Esto no significa que no reconozcamos importantes diferencias en el tipo de información que estas ofrecen, y el modo en que debe ser tratada. Cada cosa en su sitio.
Parent Preferences on Screening for Social Determinants of Health in Hospitalized Children
Authors: Gayle Tamara , Law Amy , Stokes Stacey , Page Alison , Neal Wayne , Bhansali Priti 
Published: June 2023

BACKGROUND
Although there has been much research on screening families for social determinants of health (SDOH) at pediatric outpatient visits, there is little data on family preferences about SDOH screening during hospitalization. This is of critical importance because unmet SDOH, also known as social needs, are associated with poor health outcomes.

OBJECTIVE
Our objective was to assess caregiver preferences for social needs screening in the inpatient pediatric setting.

METHODS
We surveyed a sample of caregivers of admitted patients at our freestanding tertiary-care children’s hospital between March 2021 and January 2022. Caregivers were surveyed with respect to the importance of screening, their comfort with screening, and which domains were felt to be acceptable for screening.

RESULTS
We enrolled 160 caregivers. More than 60% of caregivers were comfortable being screened for each of the social needs listed. Between 40% and 50% found screening acceptable, even if resources were unavailable. Forty-five percent preferred to be screened in private, 9% preferred to be screened by a health care team member, and 37% were comfortable being screened either in private or with a health care team member. Electronic screening was the most preferred modality (44%), and if by a health care team member, social workers were preferred over others.

CONCLUSIONS
Many caregivers reported the acceptance of and comfort with social needs screening in the inpatient setting. Our findings may help inform future hospital-wide social needs screening efforts.
Longitudinal associations between psychiatric comorbidity and the severity of gambling disorder: Results from a 36-month follow-up study of clients in Bavarian outpatient addiction care
Authors: Wullinger Pia M. , Bickl Andreas M. , Loy Johanna K. , Kraus Ludwig , Schwarzkopf Larissa 
Published: June 2023

AbstractBackground and aimsIndividuals with gambling disorder (GD) often suffer from psychiatric comorbidities. Previous studies demonstrated greater severity of GD among gamblers with psychiatric comorbidities. However, evidence on the association between psychiatric comorbidity and course of GD severity during and after outpatient treatment is sparse. This study analyses data from a longitudinal one-armed cohort study on outpatient addiction care clients over three years.MethodsWe investigated the course of GD severity using data from 123 clients in 28 outpatient addiction care facilities in Bavaria using generalized estimation equations (GEE). We applied time* interaction analyses to examine different development profiles in participants with and without (1) affective disorders, or (2) anxiety disorders, and (3) to account for the co-occurrence of both.ResultsAll participants benefitted from outpatient gambling treatment. Improvement in GD severity was poorer in participants with anxiety disorders compared to participants without anxiety disorders. The co-occurrence of affective and anxiety disorders was linked to a less favourable course of GD than the presence of affective disorders alone. However, the combined occurrence of both disorders was more favourable than the presence of anxiety disorders alone.Discussion and conclusionsOur study suggests that clients with GD, with and without psychiatric comorbidities, benefit from outpatient gambling care. Psychiatric comorbidity, especially comorbid anxiety disorders, seems to be negatively associated with the course of GD within outpatient gambling care. Addressing psychiatric comorbidity within the treatment of GD and offering individualised help are required to meet the needs of this clientele.
Study of Actinotrichia fragilis Indonesian Red Seaweed as Raw Material for Healthy Salt
Authors: Nurjanah Nurjanah , Jacoeb Agoes Mardiono , Abdullah Asadatun , Priyanto Joko Ahadi , Nurdin Naufal Muharam , Seulalae Anggrei Viona 
Published: June 2023

Healthy seaweed salt is low sodium salt from seaweed that offers health benefits for hypertension patients. Indonesian seaweed has the potential to produce healthy seaweed salt. Research to date still focuses on green and brown seaweed but there is still no report for red seaweed. Actinotrichia fragilis is one of red seaweed species that has been discovered in Indonesia’s seawater and has not yet been utilized. Thus, this study aimed to determine the chemical composition and antioxidant activity of A. fragilis flour and the optimum ratio for producing seaweed salt with a high yield, optimum %NaCl, Na/K ratio, and antioxidant activity. Seaweed salt production treatment was the ratio of seaweed flour and distilled water 1:3, 1:5, and 1:10 (w/v), extracted at 40°C for 10 minutes. The mixture was filtered, then dried at 60°C for 30 hours. Data analysis was performed by analysis of variance. The raw material for dried A. fragilis seaweed has a high ash and low-lipid content. Then the ethanol extract had a total phenolic content value of 84.34 mg GAE/g and an antioxidant activity value of 98.22 mg/L. Furthermore, the antioxidant capacity of the ethanol extract was 60.15 mmol ascorbic acid/g and 552.21 mmol Fe2+/g. The best treatment for producing A. fragilis salt is 1:10 with yield of 12.76±0.13%, %NaCl 47.22±1.38%, Na/K ratio 3.32±0.18, IC50 with DPPH and ABTS method 113 mg/L and 87.27 mg/L, total antioxidant capacity 38.21 mg/mL ascorbic acid/g, and 304.32 mmol Fe2+/g. Furthermore, A. fragilis can be used for the production of healthy seaweed salt.
Structural Racism, Historical Redlining, and Incidence of Kidney Failure in US Cities, 2012–2019
Authors: Nguyen Kevin H. , Buckle-Rashid Rachel , Thorsness Rebecca , Agbai Chinyere O. , Crews Deidra C. , Trivedi Amal N. 
Published: June 2023

Significance Statement
Residing in neighborhoods designated as grade D (hazardous) by the Home Owners' Loan Corporation (HOLC) under historical redlining—a discriminatory housing policy beginning in the 1930s—has been associated with present-day adverse health outcomes such as diabetes mortality. Historical redlining might underlie conditions in present-day neighborhoods that contribute to inequitable rates of kidney failure incidence, particularly for Black individuals, but its association with kidney disease is unknown. The authors found that among adults with incident kidney failure living in 141 metropolitan areas, residence in a historically redlined neighborhood rated grade D was associated with significantly higher kidney failure incidence rates compared with residence in a redlined grade A (best) neighborhood. These findings suggest that historical racist policies continue to affect current-day racial inequities in kidney health.

Background
Historical redlining was a 1930s federally sponsored housing policy that permitted the Home Owners' Loan Corporation (HOLC) to develop color-coded maps and grade neighborhoods' mortgage lending risk on the basis of characteristics that included racial makeup. This practice has been associated with present-day health disparities. Racial inequities in kidney disease—particularly for Black individuals—have been linked to residential segregation and other structural inequities.

Methods
Using a registry of people with incident kidney failure and digitized HOLC maps, we examined the association between residence in a historically redlined US census tract (CT) with a historical HOLC grade of D or hazardous) and present-day annual CT-level incidence of kidney failure incidence among adults in 141 US metropolitan areas, in 2012 through 2019.

Results
Age-adjusted and sex-adjusted kidney failure incidence rates were significantly higher in CTs with a historical HOLC grade D compared with CTs with a historical HOLC grade of A or best (mean, 740.7 per million versus 326.5 per million, respectively, a difference of 414.1 per million). Compared with national averages of all adults in our sample, rates of kidney failure incidence were higher for Black adults in our study sample, irrespective of CT HOLC grade. Age-adjusted and sex-adjusted incidence rates for Black persons in CTs with a HOLC grade D were significantly higher than for Black persons residing in HOLC grade A CTs (mean, 1227.1 per million versus 1030.5 per million, respectively [a difference of 196.6 per million]).

Conclusions
Historical redlining is associated with present-day disparities in kidney failure incidence, demonstrating the legacy of historical racist policies on contemporary racial inequities in kidney health.

Podcast
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/JASN/2023_08_24_JASN0000000000000165.mp3
Deep Learning Analysis of Single-Cell Data Reveals Unique Genetic Features Of COVID-19 Severities
Authors: Schonfeld Elan 
Published: June 2023

Abstract
COVID-19 was declared by the World Health Organization in 2020 to be a pandemic. Analysis of COVID-19 related genetic pathways allows for a better understanding of the possible effects and sequelae of the disease. Using 6178 scRNA sequenced human cells, having a status of control/mild/severe COVID-19 disease status, differential expression of genes and pathways was analyzed. Using Gene Set Enrichment Analysis (GSEA), mild COVID-19 was found to over-express the Influenza Pathway. In order to identify genes important in COVID-19 severity, a deep learning classifier was trained. Classifiers were repeatedly trained for this task using 10 randomly selected genes from the total number of 18,958 genes. The highest performing classifier (AUC=0.748) was trained using: AC008626.1, SGO1, RHOBTB2, RBM41, NDUFAF4P1, COX5A, ZDHHC17, STX11, IPP, NUDT5 genes. These results further illustrate the other factors contributing to mild versus severe COVID-19, as well as evidence of potential misdiagnosis or overlapping pathway effects of Influenza and COVID-19.
Brief Tele-Mindfulness Based Intervention: A Randomized Controlled Multicenter Trial
Authors: AlQarni Amani M. , ElFaki Abdulaziz , Wahab Moataza M. Abdel , AlJehani Yasser , ALKhunaizi Auday A. , Alex Johnson , Othman Sharifa A. , Amer Fatma H. , AlGhamdi Faisal A. , Alissa Khalid A. 
Published: June 2023

Abstract
Background: To enhance psychological wellbeing of health care providers (HCP) who look after patients with COVID-19. This study is a psychological intervention in COVID-19 pandemic to check at what extent can interventions based on brief mindfulness-based interventions and progressive muscle relaxation affect psychological well-being, resilience, and anxiety of HCP.
Methods: This is a randomized trial study that was conducted from July to August 2020. 147 COVID-19 frontline HCP were randomized to a 2-week virtual intervention with brief mindfulness-based intervention (MBI) or to progressive muscle relaxation(PMR). Pre and post intervention assessment were done using the (state trait anxiety–20 Item Scale), the (Connor-Davidson Resilience Scale (CD-RISC-10), and WHO – 5 Well-Being Index.
Results: The two groups had significant improvement results in the psychological wellbeing and reduction of the state anxiety but not the trait anxiety nor the resiliency. Improvement was higher among group brief mindfulness-based intervention (81.3%) than among group progressive muscle relaxation (51.8%), (X2=12.9, p=0.0001), concerning psychological wellbeing.
Conclusions: Both brief mindfulness-based intervention and progressive muscle relaxation improved the psychological wellbeing and reduced the anxiety of frontline health care providers during COVID-19 pandemic with improvement being slightly higher among Brief mindfulness-based intervention.
Trial registration: Clinicaltrial.gov identifier: NCT04656626
https://clinicaltrials.gov/ct2/show/NCT04656626?cond=Mindfulness&cntry=SA&draw=2&rank=1
How can an inferior competitor be a successful invader?
Authors: Tesfay Yohannes B. , Blaschke Annika , Kreyling Jürgen 
Published: June 2023

Abstract
The invasion of ecosystems by non-native species is recognized as one of the most significant global challenges, particularly in semiarid regions where native biodiversity is already under stress from drought and land degradation. The implicit assumption is that invaders are strong competitors, but a greenhouse pairwise experiment conducted to examine intraspecific and interspecific competition effects of Opuntia ficus-indica, a widespread invader in semiarid ecosystems, with two species native to the highlands of Eritrea, Ricinus communis and Solanum marginatum, revealed that O. ficus-indica is a weak competitor. In direct interaction, the competition in aboveground productivity measured by the logarithmic response ratio for O. ficus-indica was 3.4-fold and 5.9-fold higher than for R. communis and S. marginatum, respectively. Belowground, the native R. communis was facilitated (-1.00±0.69) by O. ficus-indica which itself suffered from high competition. This pattern became even stronger under water shortage, where aboveground competition for S. marginatum decreased 5.7-fold, and for O. ficus-indica, it increased 1.4-fold. Despite being a poor competitor, O. ficus-indica outperformed R. communis and S. marginatum in both aboveground (4.3 and 3.8 times more) and belowground (27 and 2.8 times more) biomass production, respectively. The findings of this study challenge the common interpretation that invasive species are strong competitors and highlight the importance of considering other factors, such as productivity and tolerance limits, when assessing the potential impacts of invasive species on semiarid ecosystems.
Multi-jointed pneumatic sealing disc of fluid-driven pipeline robot: Impacts of structural parameters on performance
Authors: Yue Chunmei , Ma Qiang , Yang Zhenyuan , Liu Shuhai , Liu Shangjunnan 
Published: June 2023

Abstract
Pipeline inspection gauge (PIG) is often blockage in the aging pipelines of stacked objects owing to the limitation of its passive control. In this study, a novel sealing disc with multi-jointed pneumatic webbed foot was designed which can achieve partial active control and ensure better seal performance. A finite element method (FEM) was proposed and successfully verified, then the bend performance of the sealing disc with single inflated foot was compared with whole inflated feet using the FEM, and the results show that they have good consistency. Next, the effects of two kinds of materials and five structural parameters on the performance of the sealing disc were studied using the FEM. The results show that the multi-material structure has batter performance on the bending angle and the expansion ratio compared to the same materials. As the air pressure grows, the position parameter of the joint (he) has little effect on the bending angle as well as the expansion ratio, and the bottom disc thickness (hd) has also slightly influence on the expansion ratio. Meanwhile, the thicker the webbed foot thickness (ht), the smaller the slope angle (β) and the thinner (hd), the larger the bending angle; the smaller the slope angle, the thicker the webbed foot thickness, the larger the expansion ratio. The conclusions obtained in this paper are beneficial for the design and optimization of PIG sealing discs for actively controlling. The research results provide theoretical reference for the study of intelligent and efficient pipeline pigging technology.
Fallopian tube lesions as potential precursors of early ovarian cancer: A comprehensive proteomic analysis
Authors: Salzet Michel , Wisztorski Maxence , Aboulouard Soulaimane , Roussel Lucas , Duhamel Marie , saudemont Philippe , Tristan Cardon , Narducci Fabrice , Robin Yves-Marie , Lemaire Anne-Sophie , Bertin delphine , Hajjaji Nawale , Kobaissy Firas , Fournier Isabelle , Leblanc Eric 
Published: June 2023

Abstract
Ovarian cancer is the leading cause of death from gynecologic cancer worldwide. High-grade serous carcinoma (HGSC) is the most common and deadliest subtype of ovarian cancer. While the origin of ovarian tumors is still debated, it has been suggested that HGSC originates from cells in the fallopian tube epithelium (FTE), specifically the epithelial cells in the region of the tubal-peritoneal junction. Three main lesions, p53 signatures, STILs, and STICs, have been defined based on the immunohistochemistry (IHC) pattern of p53 and Ki67 markers and the architectural alterations of the cells, using the Sectioning and Extensively Examining the Fimbriated End Protocol. In this study, we performed an in-depth proteomic analysis of these pre-neoplastic epithelial lesions guided by mass spectrometry imaging and IHC. We evaluated specific markers related to each preneoplastic lesion. The study identified specific lesion markers, such as CAVIN1, Emilin2, and FBLN5. We also used SpiderMass technology to perform a lipidomic analysis and identified the specific presence of fatty acid synthase (FASN) and fatty aldehyde dehydrogenase (FADH) with specific lipids in p53 lesions. Our study provides new insights into the molecular mechanisms underlying the progression of ovarian cancer and confirms the fimbria origin of HGSC.
Genetic modulation of brain dynamics in neurodevelopmental disorders: the impact of copy number variations on resting-state EEG
Authors: Audet-Duchesne Elisabeth , Knoth Inga , Martin Charles-Olivier , Jizi Khadije , Tamer Petra , Younis Nadine , Jacquemont Sébastien , Dumas Guillaume , Lippé Sarah 
Published: June 2023

Abstract
Research has shown that many copy number variations (CNVs) increase the risk of neurodevelopmental disorders (e.g., autism, ADHD, schizophrenia). However, little is known about the effects of CNVs on brain development and function. Resting-state electroencephalography (EEG) is a suitable method to study the disturbances of neuronal functioning in CNVs. We aimed to determine whether there are resting-state EEG signatures that are characteristic of children with pathogenic CNVs. EEG resting-state brain activity of 109 CNVs carriers (66 deletion carriers, 43 duplication carriers) aged 3 to 17 years was recorded for 4 minutes. To better account for developmental variations, EEG indices (power spectral density and functional connectivity) were corrected with a normative model estimated from 256 Healthy Brain Network controls. Results showed increased beta and gamma power in posterior regions as well as global under-connectivity in several frequency bands in CNVs carriers. Deletion and duplication carriers can be differentiated by their connectivity in low alpha frequencies: duplication carriers connectivity was more disrupted than deletion carriers. The distinctive connectivity perturbations were found to be most prominent during adolescence. The results suggest that CNVs carriers show electrophysiological alterations compared to neurotypical controls, regardless of the gene dosage effect and of their affected genomic region. Moreover, a specific signature of the brain alterations associated with duplications was found.
Hospital vulnerability to spread of respiratory infections: close contact data collection and mathematical modelling
Authors: Shirreff George , Huynh Bich-Tram , Duval Audrey , Pereira Lara Cristina , Annane Djillali , Dinh Aurélien , Lambotte Olivier , Bulifon Sophie , Guichardon Magali , Beaune Sebastien , Toubiana Julie , Kermorvant-Duchemin Elsa , Chéron Gerard , Cordel Hugues , Argaud Laurent , Douplat Marion , Abraham Paul , Tazarourte Karim , Martin-Gaujard Géraldine , Vanhems Philippe , Hilliquin Delphine , Nguyen Duc , Chelius Guillaume , Fraboulet Antoine , Temime Laura , Opatowski Lulla , Guillemot Didier 
Published: June 2023

Abstract
The transmission risk of SARS-CoV-2 within hospitals can exceed that in the general community because of more frequent close proximity interactions. However, epidemic risk across wards is still poorly described. We measured CPIs directly using wearable sensors given to all those present in a clinical ward over a 36-hour period, across 15 wards in three hospitals in spring 2020. Data were collected from 2114 participants. These data were combined with a simple transmission model describing the arrival of a single index case to the ward to estimate the risk of an outbreak. Estimated epidemic risk ranged four-fold, from 0.12 secondary infections per day in an adult emergency to 0.49 per day in general paediatrics. The risk presented by an index case in a patient varied twenty-fold across wards. Using simulation, we assessed the potential impact on outbreak risk of targeting the most connected individuals for prevention. We found that targeting those with the highest cumulative contact hours was most impactful (20% reduction for 5% of the population targeted), and on average resources were better spent targeting patients. This study reveals patterns of interactions between individuals in hospital during a pandemic and opens new routes for research into airborne nosocomial risk.