bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life cycle assessment of urban waste management in Rasht, Iran
Authors: Avarand Niloufar , Tavakoli Babak , Mahdiany Bora Khashayar 
Published: February 2023

Abstract
Population growth and industrial development have led to an increase in urban solid waste globally. Collection and disposal of urban waste remain the biggest challenges that countries face at the moment. Proper management in various stages of production, storage, transportation, and disposal of waste can ensure minimal impact to human and environmental health. There are several tools for evaluating a waste management system; among these, life cycle assessment (LCA) is an important one. This article aims to evaluate the life cycle of waste management in the city of Rasht and prioritize decisions to develop its waste management system. To achieve this purpose, four waste management scenarios were designed. In addition, the life cycle cataloging of the scenarios was done using the IWM-1 model in order to calculate the consumption of energy and also obtain the number of pollutant emission sources in each scenario. In the next step, the LCA of the scenarios was performed using the Eco-Indicator 99 index. The results of the study showed that scenario 4 had the most positive effects on the environment, with 40% compost, 25% recycling, 20% sanitary landfill, and 15% waste incineration, based on the index. Therefore, it was chosen as the best option for waste management in the city of Rasht. Integr Environ Assess Manag 2023;19:1385–1393. © 2023 SETAC
Time interval from primary melanoma to first distant recurrence in relation to patient outcomes in advanced melanoma
Authors: van Duin Isabella A. J. , Elias Sjoerd G. , van den Eertwegh Alfonsus J. M. , de Groot Jan Willem B. , Blokx Willeke A. M. , van Diest Paul J. , Leiner Tim , Verhoeff Joost J. C. , Verheijden Rik J. , van Not Olivier J. , Aarts Maureen J. B. , van den Berkmortel Franchette W. P. J. , Blank Christian U. , Haanen John B. A. G. , Hospers Geke A. P. , Kamphuis Anna M. , Piersma Djura , van Rijn Rozemarijn S. , van der Veldt Astrid A. M. , Vreugdenhil Gerard , Wouters Michel W. J. M. , Stevense‐den Boer Marion A. M. , Boers‐Sonderen Marye J. , Kapiteijn Ellen , Suijkerbuijk Karijn P. M. 
Published: February 2023

AbstractSince the introduction of BRAF(/MEK) inhibition and immune checkpoint inhibition (ICI), the prognosis of advanced melanoma has greatly improved. Melanoma is known for its remarkably long time to first distant recurrence (TFDR), which can be decades in some patients and is partly attributed to immune‐surveillance. We investigated the relationship between TFDR and patient outcomes after systemic treatment for advanced melanoma. We selected patients undergoing first‐line systemic therapy for advanced melanoma from the nationwide Dutch Melanoma Treatment Registry. The association between TFDR and progression‐free survival (PFS) and overall survival (OS) was assessed by Cox proportional hazard regression models. The TFDR was modeled categorically, linearly, and flexibly using restricted cubic splines. Patients received anti‐PD‐1‐based treatment (n = 1844) or BRAF(/MEK) inhibition (n = 1618). For ICI‐treated patients with a TFDR <2 years, median OS was 25.0 months, compared to 37.3 months for a TFDR >5 years (P = .014). Patients treated with BRAF(/MEK) inhibition with a longer TFDR also had a significantly longer median OS (8.6 months for TFDR <2 years compared to 11.1 months for >5 years, P = .004). The hazard of dying rapidly decreased with increasing TFDR until approximately 5 years (HR 0.87), after which the hazard of dying further decreased with increasing TFDR, but less strongly (HR 0.82 for a TFDR of 10 years and HR 0.79 for a TFDR of 15 years). Results were similar when stratifying for type of treatment. Advanced melanoma patients with longer TFDR have a prolonged PFS and OS, irrespective of being treated with first‐line ICI or targeted therapy.
The interplay of oncogenic signaling, oxidative stress and ferroptosis in cancer
Authors: Zeng Wentao , Long Xiaohang , Liu Pu‐Ste , Xie Xin 
Published: February 2023

AbstractOncogene‐induced hyper‐proliferation in cancer cells is accompanied by the onset of different stresses, including DNA‐replication stress, metabolic stress and oxidative stress. Excessive accumulation of reactive oxygen species (ROS) plays a pivotal and contradictory role in tumor progression. ROS dictates a multitude of cell signaling pathways to facilitate the malignant transformation of tumor cells. In the meantime, oxidative burden in tumor cells mandates reinforcing antioxidant capacity to mitigate detrimental damages. The addiction to oxidative stress and increased iron demands in cancer cells also impinges on the sensitivity of ferroptosis. Targeting redox homeostasis and ferroptosis to overcome drug resistance in cancer treatment has become an attractive research topic. However, the roles of oncogenic signaling in redox regulation and ferroptosis have not been comprehensively discussed. In this review, we summarize current knowledge regarding the interplay between redox regulation and ferroptosis in the context of cancer biology. We emphasize the implication of oncogenic signaling in redox homeostasis and ferroptosis regulation. We also provide an overview of strategies targeting oxidative stress and ferroptosis in cancer treatment.
Surviving surgery; succumbing to pharmacotherapy: A case report underscoring the importance of PRN order clarification for patient safety
Authors: Nassiri Setare , Karimian Zahra , Tahermanesh Kobra , Farasatinasab Maryam 
Published: February 2023

Abstract“Pro re nata” (PRN) or “as needed” medicine administration and usage is a relatively neglected area in medication management (pharmacotherapy/pharmaceutical care) which contributes to error‐prone use of medications and is unsafe for patients. In this case, we report the incident of diclofenac toxicity in a 51‐year‐old woman due to a prescription of 100 mg diclofenac suppositories PRN, or as needed, for postoperative pain control without explanation of the maximum daily dose (150 mg daily), which led to arbitrary consumption of 3 g of diclofenac over 5 days (600 mg daily) by the patient, and subsequent development of metabolic acidosis, acute kidney injury, and sudden cardiac arrest. The implementation of practical guidelines and training programs for health care workers to appropriately prescribe, dispense, and administer PRN medicines are necessary, and should at least include providing clarification for their indication, dose and frequency, as well as any cautionary instructions to ensure safe and effective use of such medicines.
Successful invasions to freshwater systems double with climate warming
Authors: Salis Romana K. , Brennan Georgina L. , Hansson Lars‐Anders 
Published: February 2023

AbstractAlthough invasive species are recognized as a major threat to freshwaters, little is known about how future climate warming will affect the success of invaders. Ecosystems are also often simultaneously impacted by multiple, potentially interacting, invading species and the management of species invasions can be incredibly difficult. Sensitive methods such as environmental DNA (eDNA) metabarcoding, may be key to the early detection and monitoring of invaders. Therefore, to quantify invader success, we performed an outdoor mesocosm experiment mimicking present and future temperatures (IPCC RPC 8.5) combined with a multispecies invasion of planktonic organisms collected from a region with 3–4°C higher mean temperature. 18S eDNA metabarcoding was used to track invaders and impacts on the established eukaryotic community over 22 weeks. We show that invasion success doubled with climate warming compared to present temperatures, implying a substantial increase in successful establishment of invaders in the future. In addition, after the invasion, species richness increased at warming, but not at present, climate conditions. Our quantification of the establishment of invaders in a climate warming scenario, using advanced eDNA methodologies, provides an important step in understanding and predicting how climate warming may affect the success of invasive species in the future, thereby allowing for more informed management recommendations in adapting society to climate change.
Synchronization for a class of discrete complex dynamical networks in presence of Markov jump topology and actuator saturation
Authors: Natarajan Sakthivel , Subramani Pallavi 
Published: February 2023

AbstractThis work addresses the synchronization problem for discrete complex dynamical networks (CDNs) that are associated with Markov jump outer coupling, parameter uncertainties, actuator saturation, and time delay. Especially, the uncertainties which occur in the inner coupling matrix are categorized with the use of the interval matrix approach. The main purpose of this work is to design an appropriate state feedback controller with a saturation effect that guarantees asymptotic synchronization and also satisfy a prescribed level of mixed and passivity performance for the addressed CDNs. Moreover, a new set of adequate criteria are expressed in the form of linear matrix inequalities to synchronize the considered network plant. The above synchronization criteria are retrieved with the support of an appropriate Lyapunov–Krasovskii functional, Kronecker product properties together with Jensen's inequality and Abel lemma. Eventually, the efficiency and superiority of our proposed synchronization criteria are demonstrated through two numerical examples.
Distribution of potassium, calcium, and magnesium ions from potassium fertilizers in columns of orchard soils
Authors: Yu Chieh , Geisseler Daniel J. , Brown Patrick H. , Khalsa Sat Darshan S. 
Published: February 2023

AbstractPotassium (K) in fruit and nut orchards affects productivity, water relations, and crop quality; however, information about K, calcium (Ca), and magnesium (Mg) dynamics in orchard soils is limited. This study evaluates the distribution of K, Ca, and Mg in 30‐cm soil columns following four wetting events over 70 days. Soils were a Hillgate sandy loam, a San Ysidro loam, and a Yolo loam applied with muriate of potash (KCl), microfine sulfate of potash (SOP; [K2SO4]), polyhalite (POLY; [K2SO4·MgSO4·2CaSO4·2H2O]), and an unfertilized control. Soil solution K concentrations measured at 5 cm using a porewater sampler were greater than 1400 mg K L−1 in the Hillgate sandy loam POLY treatment after the first two wetting events. Ca and Mg in soil solution were also greater for POLY when averaged across all four wetting events, likely due to greater Ca and Mg inputs. Extractable K using ammonium acetate, significantly increased after the wetting events resulting in 88% and 75% of the extractable K in the top 0–10 cm of the San Ysidro and Yolo loams, respectively. Leached K accounted for 6.2% of the SOP inputs in the Hillgate sandy, whereas only 0.3% and 1.1% in the San Ysidro and Yolo loams, respectively. Higher K leaching as well as Ca and Mg is likely due to higher cation exchange capacity in loam soils and great porosity in sandy loam soils. Our results show differences in the distribution of K, Ca, and Mg and provide insights into K fertilizer availability for orchard soils.
Electromagnetic Response of Multistage‐Helical Nano‐Micro Conducting Polymer Structures and their Enhanced Attenuation Mechanism of Multiscale‐Chiral Synergistic Effect
Authors: Li Tian , Li Jinzhe , Xu Zhengkan , Tian YingRui , Li Jiatong , Du Jiani , Meng Fanbin 
Published: February 2023

AbstractNowadays, the rapidly development of advanced antidetection technology raises stringent requirements for microwave absorption materials (MAMs) to focus more attention on wider bandwidth, thinner thickness, and lower density. Adding magnetic medium to realize broadband absorption may usually result in the decline of service performance and accelerating corrosion of MAMs. Chiral MAMs can produce extra magnetic loss without adding magnetic medium due to the unique electromagnetic cross polarization effect. However, more efforts should be taken to furtherly promote efficient bandwidth of chiral MAMs and reveal attenuation mode and modulation method of chiral structure. Herein, a novel superhelical nano‐microstructure based on chiral polyaniline and helical polypyrrole is successfully achieved via in situ polymerization strategy. The enhanced multiscale‐chiral synergistic effect contributes to broaden effective absorption bandwidth, covering 8.6 GHz at the thickness of 3.6 mm, and the minimum reflection loss can reach −51.3 dB simultaneously. Besides, to further explain response modes and loss mechanism of superhelical nano‐microstructures, the electromagnetic simulation and test analysis are applied together to reveal their synergistic enhancement attenuation mechanism. Taken together, this strategy gives a new thought of how to design, prepare, and optimize the hierarchical structure materials to achieving broadband and high‐performance microwave absorption.
Ultrasound‐Activatable g‐C3N4‐Anchored Titania Heterojunction as an Intracellular Redox Homeostasis Perturbator for Augmented Oncotherapy
Authors: He Mengting , Yu Honglian , Zhao Yinmin , Liu Jiahui , Dong Qi , Xu Zhigang , Kang Yuejun , Xue Peng 
Published: February 2023

AbstractEnergy band structure of inorganic nano‐sonosensitizers is usually optimized by surface decoration with noble metals or metal oxide semiconductors, aiming to enhance interfacial charge transfer, augment spin‐flip and promote radical generation. To avoid potential biohazards of metallic elements, herein, metal‐free graphitic carbon nitride quantum dots (g‐C3N4 QDs) are anchored onto hollow mesoporous TiO2 nanostructure to formulate TiO2@g‐C3N4 heterojunction. The direct Z‐scheme charge transfer significantly improves the separation/recombination dynamics of electron/hole (e−/h+) pairs upon ultrasound (US) stimulation, which promotes the yield of singlet oxygen (1O2) and hydroxyl radicals (·OH). The conjugated g‐C3N4 QDs with peroxidase‐mimic activity further react with the elevated endogenous H2O2 and aggravate oxidative stress. After loading prodrug romidepsin (RMD) in TiO2@g‐C3N4, stimulus‐responsive drug delivery can be realized by US irradiation. The disulfide bridge of the released RMD tends to be reduced by glutathione (GSH) into a monocyclic dithiol, which arrests cell cycle in G2/M phase and evokes apoptosis through enhanced histone acetylation. Importantly, reactive oxygen species accumulation accompanied by GSH depletion is devoted to deleterious redox dyshomeostasis, leading to augmented systemic oncotherapy by eliciting antitumor immunity. Collectively, this paradigm provides useful insights in optimizing the performance of TiO2‐based nano‐sonosensitizers for tackling critical diseases.
An investigation of distributed computing for combinatorial testing
Authors: La Chance Edmond , Hallé Sylvain 
Published: February 2023

SummaryCombinatorial test generation, also called
‐way testing, is the process of generating sets of input parameters for a system under test, by considering interactions between values of multiple parameters. In order to decrease total testing time, there is an interest in techniques that generate smaller test suites. In our previous work, we used graph techniques to produce high‐quality test suites. However, these techniques require a lot of computing power and memory, which is why this paper investigates distributed computing for
‐way testing. We first introduce our distributed graph colouring method, with new algorithms for building the graph and for colouring it. Second, we present our distributed hypergraph vertex covering method and a new heuristic. Third, we show how to build a distributed IPOG algorithm by leveraging either graph colouring or hypergraph vertex covering as vertical growth algorithms. Finally, we test these new methods on a computer cluster and compare them to existing
‐way testing tools.
Dynamics of forced escape from asymmetric truncated parabolic well
Authors: Genda Attila , Fidlin Alexander , Gendelman Oleg 
Published: February 2023

AbstractThis study presents an analytic method for the estimation of safe basins in the plane of the initial conditions of the escape of a classical particle from an asymmetrically truncated quadratic potential well. For this purpose, an analytic method to estimate the global optimum of the sum of two harmonic functions is proposed. This approach is based on the mapping of the arguments of the two harmonic terms to the surface of the unit torus, where a surrogate optimization problem obtained by the Taylor expansion of the original objective function is solved. Applying the proposed method to the aforementioned escape problem helps predict safe basins for any value of the excitation frequency provided that the exciting force is not too strong, generating essentially non‐linear effects on potential boundaries. Specifically, interesting effects with regard to the shape of safe basins occur when the natural frequency of the potential well and frequency of excitation represent the ratio of two small integers.
K-theory of noncommutative Bernoulli shifts
Authors: Chakraborty Sayan , Echterhoff Siegfried , Kranz Julian , Nishikawa Shintaro 
Published: February 2023

AbstractFor a large class of $$C^*$$

C
∗

-algebras A, we calculate the K-theory of reduced crossed products $$A^{\otimes G}\rtimes _rG$$

A

⊗
G

⋊
r

G

of Bernoulli shifts by groups satisfying the Baum–Connes conjecture. In particular, we give explicit formulas for finite-dimensional $$C^*$$

C
∗

-algebras, UHF-algebras, rotation algebras, and several other examples. As an application, we obtain a formula for the K-theory of reduced $$C^*$$

C
∗

-algebras of wreath products $$H\wr G$$

H
≀
G

for large classes of groups H and G. Our methods use a generalization of techniques developed by the second named author together with Joachim Cuntz and Xin Li, and a trivialization theorem for finite group actions on UHF algebras developed in a companion paper by the third and fourth named authors.
Imaging in rhabdomyosarcoma: a patient journey
Authors: de Vries Isabelle S. A. , van Ewijk Roelof , Adriaansen Laura M. E. , Bohte Anneloes E. , Braat Arthur J. A. T. , Fajardo Raquel Dávila , Hiemcke-Jiwa Laura S. , Hol Marinka L. F. , ter Horst Simone A. J. , de Keizer Bart , Knops Rutger R. G. , Meister Michael T. , Schoot Reineke A. , Smeele Ludi E. , van Scheltinga Sheila Terwisscha , Vaarwerk Bas , Merks Johannes H. M. , van Rijn Rick R. 
Published: February 2023

AbstractRhabdomyosarcoma, although rare, is the most frequent soft tissue sarcoma in children and adolescents. It can present as a mass at nearly any site in the body, with most common presentations in the head and neck, genitourinary tract and extremities. The optimal diagnostic approach and management of rhabdomyosarcoma require a multidisciplinary team with multimodal treatment, including chemotherapy and local therapy. Survival has improved over the last decades; however, further improvement in management is essential with current 5-year overall survival ranging from 35% to 100%, depending on disease and patient characteristics. In the full patient journey, from diagnosis, staging, management to follow-up after therapy, the paediatric radiologist and nuclear physician are essential members of the multidisciplinary team. Recently, guidelines of the European paediatric Soft tissue sarcoma Study Group, the Cooperative Weichteilsarkom Studiengruppe and the Oncology Task Force of the European Society of Paediatric Radiology (ESPR), in an ongoing collaboration with the International Soft-Tissue Sarcoma Database Consortium, provided guidance for high-quality imaging. In this educational paper, given as a lecture during the 2022 postgraduate ESPR course, the multi-disciplinary team of our national paediatric oncology centre presents the journey of two patients with rhabdomyosarcoma and discusses the impact on and considerations for the clinical (paediatric) radiologist and nuclear physician. The key learning points of the guidelines and their implementation in clinical practice are highlighted and up-to-date insights provided for all aspects from clinical suspicion of rhabdomyosarcoma and its differential diagnosis, to biopsy, staging, risk stratification, treatment response assessment and follow-up.
DEEP MOVEMENT: Deep learning of movie files for management of endovascular thrombectomy
Authors: Kelly Brendan , Martinez Mesha , Do Huy , Hayden Joel , Huang Yuhao , Yedavalli Vivek , Ho Chang , Keane Pearse A. , Killeen Ronan , Lawlor Aonghus , Moseley Michael E. , Yeom Kristen W. , Lee Edward H. 
Published: February 2023

Abstract
Objectives
Treatment and outcomes of acute stroke have been revolutionised by mechanical thrombectomy. Deep learning has shown great promise in diagnostics but applications in video and interventional radiology lag behind. We aimed to develop a model that takes as input digital subtraction angiography (DSA) videos and classifies the video according to (1) the presence of large vessel occlusion (LVO), (2) the location of the occlusion, and (3) the efficacy of reperfusion.

Methods
All patients who underwent DSA for anterior circulation acute ischaemic stroke between 2012 and 2019 were included. Consecutive normal studies were included to balance classes. An external validation (EV) dataset was collected from another institution. The trained model was also used on DSA videos post mechanical thrombectomy to assess thrombectomy efficacy.

Results
In total, 1024 videos comprising 287 patients were included (44 for EV). Occlusion identification was achieved with 100% sensitivity and 91.67% specificity (EV 91.30% and 81.82%). Accuracy of location classification was 71% for ICA, 84% for M1, and 78% for M2 occlusions (EV 73, 25, and 50%). For post-thrombectomy DSA (n = 194), the model identified successful reperfusion with 100%, 88%, and 35% for ICA, M1, and M2 occlusion (EV 89, 88, and 60%). The model could also perform classification of post-intervention videos as mTICI < 3 with an AUC of 0.71.

Conclusions
Our model can successfully identify normal DSA studies from those with LVO and classify thrombectomy outcome and solve a clinical radiology problem with two temporal elements (dynamic video and pre and post intervention).

Key Points
• DEEP MOVEMENT represents a novel application of a model applied to acute stroke imaging to handle two types of temporal complexity, dynamic video and pre and post intervention.
• The model takes as an input digital subtraction angiograms of the anterior cerebral circulation and classifies according to (1) the presence or absence of large vessel occlusion, (2) the location of the occlusion, and (3) the efficacy of thrombectomy.
• Potential clinical utility lies in providing decision support via rapid interpretation (pre thrombectomy) and automated objective gradation of thrombectomy outcomes (post thrombectomy).