bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights Into Resveratrol as an Inhibitor Against Aβ1-42 Peptide Aggregation:
A Molecular Dynamics Simulation Study
Authors: Borah Priyanka , Mattaparthi Venkata Satish Kumar 
Published: December 2022

Background:
Resveratrol (RSV), a polyphenolic compound, is reported to have anti-aggregation properties against Amyloid-beta peptides. It is, therefore, significant to understand the mechanism of inhibition of Aβ1-42 peptide aggregation by the RSV at the molecular level. We have used Molecular docking along with Molecular dynamics (MD) simulation techniques to address the role of RSV in the inhibition of Aβ1-42 pep-tide aggregation.

Objective:
To understand the role of Resveratrol on the Aβ1-42 peptide aggregation.

Method:
In this computational study, we have docked the RSV to Aβ1-42 peptide using Molecular Docking software and then performed MD simulation for the Aβ1-42 peptide monomer Aβ1-42 peptide-RSV complex using the AMBER force field. From the analysis of MD trajectories, we obtained salient structural features and determined the Binding Free Energy(BFE) and Per-residue Energy Decomposition Analysis (PRED) using MM-PBSA/GBSA method.

Results:
The secondary structure and the conformational analysis obtained from MD trajectories show that the binding of RSV with the Aβ1-42 peptide monomer causes an increase in the helical content in the structure of the Aβ1-42 peptide. The BFE and PRED results show a high binding affinity (GBtotal=-11.07 kcal mol-1; PBtotal= -1.82 kcal mol-1) of RSV with Aβ1-42 peptide. Also, we found the RSV to interact with cru-cial residues (Asp 23 and Lys 28) of the Aβ1-42 peptide. These residues play a signif-icant role in facilitating the formation of toxic amyloid oligomers and amyloid fibrils. The salt bridge interaction between these residues D23–K28 was found to be destabi-lized in the Aβ1-42 peptide when it is complexed with RSV.

Conclusion:
In summary, it can be concluded that Resveratrol greatly aids the preven-tion of Aβ1-42 peptide aggregation. Therefore, it can be considered a possible drug candidate for therapeutic strategies for Alzheimer’s disease.
Preferences for a Mental Health Support Technology Among Chinese Employees: Mixed Methods Approach
Authors: Sun Sijin , Zhang Zheyuan , Tian Mu , Mougenot Celine , Glozier Nick , Calvo Rafael A 
Published: December 2022

Background
Workplace mental health is under-studied in China, making it difficult to design effective interventions. To encourage the engagement with interventions, it is crucial to understand employees’ motivation toward seeking help through technologies.

Objective
This study aimed to understanding how Chinese employees view digital mental health support technology and how mental health support technology could be designed to boost the motivation of Chinese employees to use it.

Methods
A mixed methods approach was used. In total, 458 Chinese employees (248/458, 54% female) in 5 industries (manufacturing, software, medical, government, and education) responded to a survey, and 14 employees and 5 managers were interviewed.

Results
Government data and employee responses showed that mental health support in China is limited. In the workplace, Chinese employees experience a lower sense of autonomy satisfaction compared with competence and relatedness. Although managers and employees try to empathize with those who have mental health issues, discrimination and the stigma of mental illness are rife in Chinese workplaces. Digital technologies are perceived as a potential medium for mental health interventions; however, privacy is a major concern.

Conclusions
The results of this study demonstrated the potential of self-help digital mental health support for Chinese employees. Interdisciplinary cooperation between design engineers and mental health researchers can contribute toward understanding the issues that engage or disengage users with digital mental health interventions.
Systematized Nomenclature of Medicine–Clinical Terminology (SNOMED CT) Clinical Use Cases in the Context of Electronic Health Record Systems: Systematic Literature Review
Authors: Vuokko Riikka , Vakkuri Anne , Palojoki Sari 
Published: December 2022

Background
The Systematized Medical Nomenclature for Medicine–Clinical Terminology (SNOMED CT) is a clinical terminology system that provides a standardized and scientifically validated way of representing clinical information captured by clinicians. It can be integrated into electronic health records (EHRs) to increase the possibilities for effective data use and ensure a better quality of documentation that supports continuity of care, thus enabling better quality in the care process. Even though SNOMED CT consists of extensively studied clinical terminology, previous research has repeatedly documented a lack of scientific evidence for SNOMED CT in the form of reported clinical use cases in electronic health record systems.

Objective
The aim of this study was to explore evidence in previous literature reviews of clinical use cases of SNOMED CT integrated into EHR systems or other clinical applications during the last 5 years of continued development. The study sought to identify the main clinical use purposes, use phases, and key clinical benefits documented in SNOMED CT use cases.

Methods
The Cochrane review protocol was applied for the study design. The application of the protocol was modified step-by-step to fit the research problem by first defining the search strategy, identifying the articles for the review by isolating the exclusion and inclusion criteria for assessing the search results, and lastly, evaluating and summarizing the review results.

Results
In total, 17 research articles illustrating SNOMED CT clinical use cases were reviewed. The use purpose of SNOMED CT was documented in all the articles, with the terminology as a standard in EHR being the most common (8/17). The clinical use phase was documented in all the articles. The most common category of use phases was SNOMED CT in development (6/17). Core benefits achieved by applying SNOMED CT in a clinical context were identified by the researchers. These were related to terminology use outcomes, that is, to data quality in general or to enabling a consistent way of indexing, storing, retrieving, and aggregating clinical data (8/17). Additional benefits were linked to the productivity of coding or to advances in the quality and continuity of care.

Conclusions
While the SNOMED CT use categories were well supported by previous research, this review demonstrates that further systematic research on clinical use cases is needed to promote the scalability of the review results. To achieve the best out-of-use case reports, more emphasis is suggested on describing the contextual factors, such as the electronic health care system and the use of previous frameworks to enable comparability of results. A lesson to be drawn from our study is that SNOMED CT is essential for structuring clinical data; however, research is needed to gather more evidence of how SNOMED CT benefits clinical care and patient safety.
Evaluation of miniscrew-assisted rapid palatal expansion success by comparing width of circummaxillary sutures before expansion in adult male patients
Authors: Lee Ji-Min , Choi Sung-Hwan , Choi Yoon Jeong , Lee Kee-Joon , Yu Hyung-Seog 
Published: December 2022

ABSTRACTObjectivesTo investigate the relationship between circummaxillary sutures and miniscrew-assisted rapid palatal expansion (MARPE) success in adult male patients and to evaluate the correlation between the width of the sutures and the maxilla expansion ratio.Materials and MethodsThis retrospective study comprised 40 adult male patients treated with MARPE divided into a separation group (N = 20, mean age, 21.9 years) consisting of subjects with midpalatal suture opening and a nonseparation group (N = 20, mean age, 21.7 years) consisting of subjects with no midpalatal suture opening. Cone-beam computed tomography images were obtained before MARPE expansion for both groups and after expansion for the separation group. Vertical and horizontal skeletal relationships, palate length, and widths of 10 circummaxillary sutures before expansion were compared. The correlation between maxilla expansion ratio (jackscrew expansion to maxillary expansion ratio) and circummaxillary suture widths was also analyzed in the separation group.ResultsThere were no significant differences in age, vertical and horizontal skeletal relationships, and palate length between the two groups. Zygomaticomaxillary, pterygomaxillary, midpalatal, and transverse palatine sutures showed significantly greater width in the separation group (P &lt; .05). The zygomaticomaxillary suture showed the greatest difference (Δ = 0.36 mm) between the groups. The zygomaticomaxillary and pterygomaxillary sutures showed significant positive correlation with the maxilla expansion ratio (P &lt; .01).ConclusionsIn adult male patients, greater circummaxillary suture widths before MARPE expansion, especially zygomaticomaxillary and pterygomaxillary sutures, resulted in a better chance of successful suture separation and more maxillary expansion.
An Examination of Whether Diabetes Control and Treatments Are Associated With Change in Frailty Index Across 8 Years: An Ancillary Exploratory Study From the Action for Health in Diabetes (Look AHEAD) Trial
Authors: Simpson Felicia R. , Justice Jamie N. , Pilla Scott J. , Kritchevsky Stephen B. , Boyko Edward J. , Munshi Medha N. , Ferris Chloe K. , Espeland Mark A. ,   the Look AHEAD Research Group
Published: December 2022

OBJECTIVEThe aim of this study was to describe cross-sectional and longitudinal associations between glycated hemoglobin (HbA1c) levels and strategies to control type 2 diabetes with baseline levels and 8-year changes in a deficit accumulation frailty index (FI), a commonly used marker of biological aging.RESEARCH DESIGN AND METHODSWe conducted exploratory analyses from 4,169 participants, aged 45–76 years, who were followed in the Action for Health in Diabetes (Look AHEAD) randomized controlled clinical trial, pooling data across intervention groups. We related baseline and 8-year levels of HbA1c with FI scores using analyses of variance and covariance. Associations between 8-year changes in FI and the use of diabetes medication classes and weight changes were assessed with control for HbA1c levels. Inverse probability weighting was used to assess bias associated with differential follow-up.RESULTSBaseline and average HbA1c levels over time of &lt;7%, as compared with ≥8%, were associated with less increase in FI scores over 8 years (both P ≤ 0.002). After adjustment for HbA1c, use of metformin and weight loss &gt;5% were independently associated with slower increases in frailty.CONCLUSIONSLower HbA1c levels among individuals with diabetes are associated with slower biological aging as captured by a deficit accumulation FI. Strategies to control diabetes through weight loss or metformin use may also slow aging.
L’ORDINE DELLE PAROLE NEL "CHRONICON VULTURNENSE"
Authors: CICCARELLI Rossana 
Published: December 2022

Word Order in the Chronicon Vulturnense. The aim of this paper is to present a linguistic analysis of the Chronicon Vulturnense, a “roborated chronicle” written in Latin in the first half of the 12th century by a monk of the monastery of San Vincenzo at Volturno. The work, which is characterised by the repeated interweaving of chronological and documentary parts, offers interesting insights for the study of the interaction and co-presence of different linguistic repertoires in the written forms of the centuries immediately following the first attestations of vernacular Italian. In particular, the study of word order shows a tendency towards constructions with the verb in a final position in narrative parts and in a central position in documentary parts, while throughout the chronicle proper there is a high frequency of constructions with postverbal subjects, as occurs in many texts of ancient Italian.
Article history: Received 2 August 2022; Revised 8 October 2022; Accepted 31 October 2022; Available online 20 December 2022; Available print 30 December 2022.
REZUMAT. Ordinea cuvintelor în Chronicon Vulturnense. Scopul acestei lucrări este de a propune o analiză lingvistică a Chronicon Vulturnense, o „cronică roborata” scrisă în limba latină în prima jumătate a secolului al XII-lea de către un călugăr de la mănăstirea San Vincenzo al Volturno. Lucrarea, care se caracterizează prin împletirea continuă a unor părți cronologice și documentare, oferă o interesantă sursă de reflecție pentru studiul interacțiunii și coexistenței diferitelor repertorii lingvistice prezente în scrierile din secolele imediat următoare primelor atestări ale limbii italiene vernaculare. În special, studiul ordinii cuvintelor arată o tendință spre construcții cu verbul în poziție finală în părțile narative și în poziție centrală în părțile documentare, în timp ce în întreaga cronică există o frecvență ridicată a construcțiilor cu subiect postverbal, așa cum se întâmplă în multe texte italiene veche.
Cuvinte-cheie: Tranziție latino-romantică, cronici medievale, latină medievală, ordinea cuvintelor, pragmatică, subiect postverbal, italiană antică
Who Am I?: Re-envisioning the question of Muslim identity in Tariq Ali’sThe Stone WomanandA Sultan in Palermo
Authors: Hussain Zakir , Mishra Binod 
Published: December 2022

AbstractThis article examines Tariq Ali’s novelsThe Stone Woman(2000) andA Sultan in Palermo(2005) to critique the question of identity discourse by drawing inspiration from various cultures rooted in a distinctively Islamic landscape and culture. Muslim identity, like any other, is separately constructed and determined by language, religion, sect, and various other roles. It examines the creation of Muslim identity and strives to comprehend the segregation they have demonstrated in the postcolonial context. This identity discourse emerged in colonial discursive practices that positioned Muslims as “Other” under colonial rule. This paper draws upon theoretical concepts of postcolonial theory to challenge the stereotypical representation of Islam often circulated in Eurocentric discourses. We do this by focusing on Tariq Ali’s ways of constructing Muslim identities through fictional representations. Through this discussion, we critique stereotypical tropes evident in Eurocentric discourses, which too often conflate professions of Muslim identity with religious fundamentalism.
The creation process of a synthetic textual medium
Authors: Husárová Zuzana 
Published: December 2022

Abstract
The paper presents the contemporary phenomenon of synthetic textual media that write poetry. It describes the several stages of preparation, conceptualization and building of a neural network that generates poetry. The neural network introduced in this article, called Liza Gennart, is the author of the book Výsledky vzniku (‘Outcomes of Origin’, 2020) and of several other projects, among them an interactive multimedia installation. The author of this article uses a practice-led research method to write about her own collaborative project that was conducted in collaboration with the programmer Ľubomír Panák.
Application of Discriminative Training Algorithm Based on Intelligent Computing in English Translation Evaluation
Authors: Li Xue 
Published: December 2022

AbstractAiming at the higher correlation between the objective evaluation of computer English speech and the subjective evaluation of experts, an acoustic model based on discriminative training is proposed to improve the confidence score of objective evaluation. First, the process of obtaining the pronunciation quality evaluation score of the speech vector by the forced matching algorithm is introduced, and then the mathematical theory of hypothesis testing is used to prove that the acoustic model trained based on the discriminative algorithm ‘minimum phoneme error’ is more effective than the acoustic model based on the traditional maximum likelihood algorithm. Confidence scores close to subjective assessments are obtained. By calculating the correlation coefficient of the subjective and objective evaluation results, the experiment verifies that the speech evaluation system using the discriminative acoustic model can give a higher confidence score and proposes a data selection method based on dynamic weighting, which is applied to continuous speech recognition in the discriminative training of the acoustic model. This method combines the posterior probability and the phoneme accuracy rate to select the data. First, the Beam algorithm of the posterior probability is used to trim the word graph. On this basis, according to the error rate of the candidate path where the candidate word is located, the probability dynamically assigns different weights to the candidate words; second, by calculating the confusion degree between the phoneme pairs, different penalty weights is dynamically added to the easily confused phoneme pairs to calculate the phoneme accuracy; finally, the expected accuracy of the obtained arc is calculated on the basis of the probability distribution. The Gaussian function is used to softly weight the expected phoneme accuracy of all competing arcs. The experimental results show that compared with the minimum phoneme error criterion, the dynamic weighting method has higher recognition accuracy and can effectively reduce the training time.
Isomorphism between Spaces of Multilinear Maps and Nested Compositions over Real Normed Vector Spaces
Authors: Nakasho Kazuhisa , Futa Yuichi 
Published: December 2022

Summary
This paper formalizes in Mizar [1], [2], that the isometric isomorphisms between spaces formed by an (n + 1)-dimensional multilinear map and an n-fold composition of linear maps on real normed spaces. This result is used to describe the space of nth-order derivatives of the Frechet derivative as a multilinear space. In Section 1, we discuss the spaces of 1-dimensional multilinear maps and 0-fold compositions as a preparation, and in Section 2, we extend the discussion to the spaces of (n + 1)-dimensional multilinear map and an n-fold compositions. We referred to [4], [11], [8], [9] in this formalization.
Transmasculinities in Nonbinary Autobiographical Writing
Authors: Zlámalová Karolína 
Published: December 2022

Abstract
This article discusses the representations and narratives of transmasculinities in selected works by contemporary Anglophone nonbinary writers assigned female at birth. After briefly introducing the primary sources, I explain how this selection of texts allows for an analysis that contributes to widening the conventional conceptualisation of masculinities as related only to biological men and trans men, and I specify the kinds of masculinities discussed in the article. I then concentrate on three prominently featured themes in the analysed narratives: rejection and erasure within the lesbian and feminist communities, confusion caused by the authors’ identities in their everyday lives, and nonbinary parenting-related issues. Exploring how the authors write about these themes illuminates not only how they textually construct their diverse masculinities but also some of the key challenges they navigate: identity unintelligibility, invisibility, and the threat of involuntary complicity in the patriarchal order.
Mahesh Dattani’s Do the Needful: A Tussle Between Innate Sexuality and Imposed Identity
Authors: Chhavi  , Bhushan Rajiv , Tripathi Priyanka 
Published: December 2022

Abstract
Although the issues related to sexuality are of prime importance in the contemporary world, in the Indian society they are closeted and ignored even today. Several social injunctions are conceptualized against men with alternative sexualities. To avoid social stigma, men refrain from coming out of the closet and accepting their natural sexual identity and orientation. However, there are certain playwrights who have addressed this otherwise taboo subject of sexuality on the Indian Stage. Mahesh Dattani is one amongst them. His plays firmly assert that gender and sexuality are concepts that are not confined to one’s biological orientation, but rather go beyond it. They are conditioned by socio-cultural norms and hegemonic practices. He elucidates how the socio-cultural determinants of gender and sexuality contradict one’s own individual instincts, sexual preferences and lived experiences. With reference to his famous play Do the Needful, this paper gives a brief account of the condition of Indian theatre pre- and post-colonization and projects the camouflaging techniques adopted by the discursive identities of gay people, for example, in order to conspicuously feature as straight and normal. It outlines the social constructions associated with gays in India and how these formations compel Indian men to internalize and succumb to the conventional norms of heterosexuality as the only acceptable norms.
Gertrude Stein’s Experience of Expatriation and Settlement in the Autobiography of Alice B. Toklas
Authors: Tucan Gabriela 
Published: December 2022

Abstract
The article examines The Autobiography of Alice B. Toklas, by Gertrude Stein. Filtered through the eyes of her lover, the text’s focus is on Stein’s artistic growth. Published in 1933 and written from “the happily distant perspective of the 1930s” (Benstock, 1986, p. 144), The Autobiography shows how Stein copes with the isolation and despair of her first years of expatriation in Paris. The paper argues that Stein was only able to perform in-depth acts of self-analysis once she had settled down in her troubled subjective geography.
Dynamic Analysis and Experiment of Underactuated Double-Pendulum Anti-Swing Device for Ship-Mounted Jib Cranes
Authors: Wang Jianli , Liu Kexin , Wang Shenghai , Chen Haiquan , Sun Yuqing , Niu Anqi , Li Haolin 
Published: December 2022

Abstract
This paper proposes a three degrees of freedom parallel anti-swing method by the main and auxiliary cables to address the problems related to underactuated double-pendulum anti-swing for a ship-mounted jib crane. By analysing the dynamic coupling relationship between the swing of the hook and the payload, it seeks to establish an accurate dynamic model of the anti-swing device under the ship’s rolling and pitching conditions, and discusses the influence of ship excitation, the crane state, load posture and anti-swing parameters on the in-plane and out-of-plane swing angles. The analysis shows that the primary pendulum reduces the in-plane angle by 90% and the out-of-plane angle by 80%, the in-plane angle of the secondary pendulum is reduced by 90%, and the out-of-plane angle is reduced by 80%. The reliability of the simulation data is verified through experiments.