bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan antara overekspresi Vascular Endothelial Growth Factor dengan Er, Pr, Her-2, Ki67 pada subtipe molekular karsinoma payudara invasif tidak spesifik
Authors: Ellyzar Ellyzar , Sulastri Henny , Murti Krisna , Theodorus Theodorus 
Published: May 2023

Kanker payudara memiliki perilaku biologik yang sangat heterogen sehingga diperlukan banyak parameter untuk menentukan faktor prognosis, salah satunya adalah Vascular Endothelial Growth Factor (VEGF). VEGF merupakan mitogen pada sel endotel. Overekspresi VEGF pada karsinoma payudara invasif tidak spesifik berhubungan dengan agresivitas sel tumor, metastasis, angka kekambuhan lebih besar serta rendahnya angka kelangsungan hidup secara keseluruhan. Overekspresi VEGF pada tumor payudara juga berkorelasi dengan ekspresi reseptor hormonal, status HER2 dan indeks Ki67. Tujuan penelitian ini mengetahui korelasi antara overekspresi VEGF dengan ER, PR, HER-2 dan Ki67 pada subtipe molekular karsinoma payudara invasif tidak spesifik. Desain penelitian ini adalah serial kasus, menggunakan sampel 40 penderita karsinoma payudara invasif tidak spesifik, stadium I-IIB yang telah dilakukan pulasan imunohistokimia ER, PR, HER-2, Ki67 dan dikelompokkan berdasarkan subtipe molekular luminal A, B, HER-2 (+) dan basal-like (EGFR +) periode 2014-2015 di Sentra Diagnostik Patologi Anatomi Fakultas Kedokteran Universitas Sriwijaya (FK UNSRI)/RSMH periode 1 januari 2014 hingga 31 desember 2015, kemudian dilakukan pulasan imunohistokimia dengan menggunakan antibodi anti VEGF-A. Pada hasil ekpresi VEGF ?10% terdapat pada kelompok reseptor estrogen, progesteron dan status Ki67 yang positif yaitu masing-masing sebesar 26%, 24% dan 52,5%, sedangkan pada status HER-2, overekspresi VEGF terdapat pada kelompok HER-2 yang negatif yaitu 62,5%. hasil yang berhubungan dengan overekspresi VEGF adalah reseptor progesteron pada subtipe lumial A (p = 0,035) serta Ki67 (p = 0,006) pada tipe basal-like.Ada kecenderungan perbedaan parameter prognosis karsinoma payudara invasif antara overekspresi VEGF dengan ekspresi ER,PR, HER-2 dan Ki67 pada masing-masing subtipe molekular karsinoma payudara invasif tidak spesifik.
Dye degradation, antimicrobial activity, and molecular docking analysis of carbon sphere and graphene oxide–doped aluminum oxide
Authors: Zubair Arshad Hafiz Muhammad , Imran Muhammad , Haider Ali , Shahzadi Iram , Mustajab Muhammad , Ul-Hamid Anwar , Nabgan Walid , Medina Francisco , Aslam Sadaf , Ikram Muhammad 
Published: May 2023

In this research work, pristine and various concentrations (2.4 wt%) of graphene oxide (GO)/carbon sphere (CS)–doped Al2O3 nanostructures (NSs) were synthesized with the chemical sol–gel method. Aluminum oxide (Al2O3) exhibits quick recombination of electrons and holes with a low specific surface to limit catalytic and antibacterial activities. Al2O3 doped with CS is good in wastewater treatment and reduces the size of NSs. The incorporation of graphene oxide (GO) into Al2O3 at different concentrations (2 and 4 wt%) enhances both the structural and chemical stabilities of the resulting material while concurrently decreasing the number of charge carriers and reducing the band gap energy. This modified Al2O3-GO composite exhibits promising potential for utilization in dye degradation and antibacterial activity. A series of characterizations were performed to investigate the structural, morphological, and optical properties. The NSs exhibited excellent catalytic activity (CA) against rhodamine B (RhB) dye in acidic, basic, and neutral media. The antimicrobial activity was tested against Escherichia coli. Pairs of electrons and holes are the primary building blocks for the production of reactive oxygen species (ROS), which causes bacteria to die. The significant inhibition zones against E. coli were calculated to be approximately 5.65 mm when compared to ciprofloxacin. Moreover, in silico investigations have revealed the possible inhibitory impact of produced nanomaterials (GO/CS-doped Al2O3) on DNA gyrase and FabI enzymes of fatty acid biosynthesis.
Brain-derived neurotrophic factor contributes to neurogenesis after intracerebral hemorrhage: a rodent model and human study
Authors: Lin Ting-Chun , Tsai Yi-Chieh , Chen Yun-An , Young Tai-Horng , Wu Chung-Che , Chiang Yung-Hsiao , Kao Chia-Hsin , Huang Abel Po-Hao , Hsu Yi-Hua , Chen Kai-Yun , Tsai Li-Kai 
Published: May 2023

Background and purposeIntracerebral hemorrhage (ICH) enhances neurogenesis in the subventricular zone (SVZ); however, the mechanism is not fully understood. We investigated the role of brain-derived neurotrophic factor (BDNF) in post-ICH neurogenesis in a rodent model and in patients with ICH using cerebrospinal fluid (CSF).MethodsA rat model of ICH was constructed via stereotaxic injection of collagenase into the left striatum. Patients with ICH receiving an external ventricular drain were prospectively enrolled. CSF was collected from rats and patients at different post-ICH times. Primary cultured rat neural stem cells (NSCs) were treated with CSF with or without BDNF-neutralized antibody. Immunohistochemistry and immunocytochemistry were used to detect NSC proliferation and differentiation. The BDNF concentration in CSF was quantified using enzyme-linked immunosorbent assays (ELISA).ResultsIn the rat model of ICH, the percentage of proliferating NSCs and neuroblasts in SVZ was elevated in bilateral hemispheres. The cultured rat NSCs treated with CSF from both rats and patients showed an increased capacity for proliferation and differentiation toward neuroblasts. BDNF concentration was higher in CSF collected from rats and patients with ICH than in controls. Blocking BDNF decreased the above-noted promotion of proliferation and differentiation of cultured NSCs by CSF treatment. In patients with ICH, the BDNF concentration in CSF and the neurogenesis-promoting capacity of post-ICH CSF correlated positively with ICH volume.ConclusionBDNF in CSF contributes to post-ICH neurogenesis, including NSC proliferation and differentiation toward neuroblasts in a rat model and patients with ICH.
What we talk about when we talk about COVID-19 vaccination campaign impact: a narrative review
Authors: Hastenreiter Filho Horácio N. , Peres Igor T. , Maddalena Lucas G. , Baião Fernanda A. , Ranzani Otavio T. , Hamacher Silvio , Maçaira Paula M. , Bozza Fernando A. 
Published: May 2023

BackgroundThe lack of precise definitions and terminological consensus about the impact studies of COVID-19 vaccination leads to confusing statements from the scientific community about what a vaccination impact study is.ObjectiveThe present work presents a narrative review, describing and discussing COVID-19 vaccination impact studies, mapping their relevant characteristics, such as study design, approaches and outcome variables, while analyzing their similarities, distinctions, and main insights.MethodsThe articles screening, regarding title, abstract, and full-text reading, included papers addressing perspectives about the impact of vaccines on population outcomes. The screening process included articles published before June 10, 2022, based on the initial papers’ relevance to this study’s research topics. The main inclusion criteria were data analyses and study designs based on statistical modelling or comparison of pre- and post-vaccination population.ResultsThe review included 18 studies evaluating the vaccine impact in a total of 48 countries, including 32 high-income countries (United States, Israel, and 30 Western European countries) and 16 low- and middle-income countries (Brazil, Colombia, and 14 Eastern European countries). We summarize the main characteristics of the vaccination impact studies analyzed in this narrative review.ConclusionAlthough all studies claim to address the impact of a vaccination program, they differ significantly in their objectives since they adopt different definitions of impact, methodologies, and outcome variables. These and other differences are related to distinct data sources, designs, analysis methods, models, and approaches.
Perancangan Sistem Rekam Medis Berbasis Web Pada Klinik Azila Aesthetic Dental Care Kota Jambi
Authors: Alysia Ayu , Rohaini Eni , B M. Riza Pahlevi 
Published: May 2023

Klinik Azila Aesthetic Dental Care Kota Jambi masih dilakukan dengan pencatatan maupun pembuatan laporan data rekam medis. laporan data pasien, dan laporan data dokter. Untuk itu diperlukannya manajemen agar kegiatan pengolahan data-data pada Klinik Azila Aesthetic Dental Care Kota Jambi bisa menjadi lebih baik dengan cara memanfaatkan sistem yang terkomputerisasi dimana kegiatan ini dapat mempermudah pengolahan data-data yang dibutuhkan, sehingga kinerja pada Klinik Azila Aesthetic Dental Care Kota Jambi akan menjadi lebih baik lagi. Tujuan dari penelitian ini adalah menganalisis sistem yang sedang berjalan untuk mengatasi permasalahan Klinik Pergigian Azira Estetika dengan merancang sistem pencatatan medis berbasis web pada Klinik Perawatan Gigi Estetika Azira Kota Jambi. Metode pengembangan sistem menggunakan model waterfall. Implementasi penelitian ini menggunakan bahasa pemrograman PHP dan MySQL DBMS untuk membuat aplikasi pengolahan data yang diharapkan dapat mempermudah dalam pengolahan dan pelaporan data.
Kata Kunci : Perancangan, Teknik Informatika, Rekam medis, Klinik Perawatan Gigi, Pasien
An improved calculation scheme of electron flow in a propagator method for solving the Boltzmann equation
Authors: Kobayashi Tsukasa , Sugawara Hirotake , Ikeda Kei 
Published: May 2023

Abstract
In order to accurately evaluate the electron acceleration process in the calculation of the time evolution of the electron velocity distribution function (EVDF) based on the Boltzmann equation, an improved scheme blending upwind and central differences is introduced into the propagator method (PM). While the previous PM based on the upwind scheme needs fine cells to obtain an accurate EVDF at low electric fields, the improved PM is robust against coarse cells, which allows the reduction of cell resolution. Calculations of the EVDF in Ar under RF electric fields demonstrated that the blending scheme can provide satisfactorily accurate results even with cells about tenfold larger than the upwind case at low reduced electric fields below 1 Td, which leads to much shorter computational time because the reduction in the number of cells satisfactorily compensates for the complexity of the blending scheme. This technique has been built into a new user-friendly PM software named BOSPROM.
Characterization of local non-equilibrium phonons in bulk MoS2 probed by temperature-dependent Raman scattering
Authors: Liu Ruian , Miyata Masanobu , Koyano Mikio 
Published: May 2023

Abstract
This study presents an experimental implementation to determine the temperature dependence of Raman spectra of bulk 2H-MoS2 in the temperature range of 300–650 K. In addition, we have measured

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does not correspond to the equilibrium population of optical phonons, thus indicating that the measurement was not in thermal equilibrium but in a thermal steady state under laser irradiation. We conclude that this is caused by the difference in relaxation times in the thermal steady state.
Implementing Cross-Platform Business Logic in Mobile Applications using Hexagonal Architecture
Authors: Nunkesser Robin 
Published: May 2023

<p>Most modern mobile applications need to be available on iOS and Android. Frequent code sharing is desirable. While dedicated cross- and multiplatform development tools achieve this goal, there are also situations where more flexibility is necessary. If code for one platform already exists or if, for example, the UI needs to be highly platform-optimized, a high volume of shared business logic could be one of the main implementation goals. The Hexagonal Architecture is a global architecture, providing an extendable approach suitable for small and large projects and helping to achieve more independence from frameworks and external agencies and better testability. This paper discusses the use of the Hexagonal Architecture to simplify business logic sharing. </p>
Transduction in MEMS/NEMS Based Actuation and Sensing
Authors: Pachkawade Vinayak 
Published: May 2023

<p>This article offers rigorous overview of diverse transduction methods that have enabled successful development of Micro/Nanoelectromechanical Systems (MEMS/NEMS) components and devices used for sensing and actuation. The paper focuses on providing educational insights on the transductions used in MEMS/NEMS, and curates the latest applications and design trends. The review begins by classifying various transduction techniques, explaining cross-domain couplings, presents an underlying working principles and governing equations that drive transducer operation. Both actuation and sensing modes of each transduction method are exclusively explained and discussed, accompanied by the latest case study examples and references. The article provides detailed scientific insights into the widely used transduction techniques in MEMS/NEMS, addresses effective comparative performance of one over another (force, displacement, resonance frequency, quality factor, noise, nonlinearity, energy requirements, etc.) The paper also highlights emerging materials and fabrication platforms using which these transducers are developed </p>
Opticalparametric amplifiers in SiN waveguides coated with graphene oxide thin films
Authors: Moss David 
Published: May 2023

<p>Optical parametric amplification (OPA) represents a powerful solution to achieve broadband amplification in wavelength ranges beyond the scope of conventional gain media, for generating high-power optical pulses, optical microcombs, entangled photon pairs and a wide range of other applications. Here, we demonstrate optical parametric amplifiers based on silicon nitride (Si3N4) waveguides integrated with two-dimensional (2D) layered graphene oxide (GO) films. We achieve precise control over the thickness, length, and position of the GO films using a transfer-free, layer-by-layer coating method combined with accurate window opening in the chip cladding using photolithography. Detailed OPA measurements with a pulsed pump for the fabricated devices with different GO film thicknesses and lengths show a maximum parametric gain of ~24.0 dB, representing a ~12.2 dB improvement relative to the device without GO. We perform a theoretical analysis of the device performance, achieving good agreement with experiment and showing that there is substantial room for further improvement. This work demonstrates a new way of achieving high photonic integrated OPA performance by incorporating 2D materials. </p>
Distributed Noncooperative MPC for Energy Scheduling of Charging and Trading Electric Vehicles in Energy Communities
Authors: Mignoni Nicola , Carli Raffaele , Dotoli Mariagrazia 
Published: May 2023

<p>In this paper, we propose a novel control strategy for the optimal scheduling of an energy community constituted by prosumers and equipped with unidirectional vehicle-to-grid (V1G) and vehicle-to-building (V2B) capabilities. In particular, V2B services are provided by long-term parked electric vehicles (EVs), used as temporary storage systems by prosumers, who in turn offer the V1G service to EVs provisionally plugged into charging stations. To tackle the stochastic nature of the framework, we assume that EVs communicate their parking and recharging time distribution to prosumers, allowing them to improve the energy allocation process. Acting as selfish agents, prosumers and EVs interact in a rolling horizon control framework with the aim of achieving an agreement on their operating strategies. The resulting control problem is formulated as a generalized Nash equilibrium problem, addressed through the variational inequality theory, and solved in a distributed fashion leveraging on the accelerated distributed augmented Lagrangian method, showing sufficient conditions for guaranteeing convergence. The proposed model predictive control approach is validated through numerical simulations under realistic scenarios. </p>
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<p>This preprint has been accepted for publication in<em> IEEE Transactions on Control Systems Technology</em>. </p>
<p><br></p>
<p><strong>How to cite</strong>: N. Mignoni, R. Carli and M. Dotoli, "Distributed Noncooperative MPC for Energy Scheduling of Charging and Trading Electric Vehicles in Energy Communities," in IEEE Transactions on Control Systems Technology.</p>
Distributed Noncooperative MPC for Energy Scheduling of Charging and Trading Electric Vehicles in Energy Communities
Authors: Mignoni Nicola , Carli Raffaele , Dotoli Mariagrazia 
Published: May 2023

<p>In this paper, we propose a novel control strategy for the optimal scheduling of an energy community constituted by prosumers and equipped with unidirectional vehicle-to-grid (V1G) and vehicle-to-building (V2B) capabilities. In particular, V2B services are provided by long-term parked electric vehicles (EVs), used as temporary storage systems by prosumers, who in turn offer the V1G service to EVs provisionally plugged into charging stations. To tackle the stochastic nature of the framework, we assume that EVs communicate their parking and recharging time distribution to prosumers, allowing them to improve the energy allocation process. Acting as selfish agents, prosumers and EVs interact in a rolling horizon control framework with the aim of achieving an agreement on their operating strategies. The resulting control problem is formulated as a generalized Nash equilibrium problem, addressed through the variational inequality theory, and solved in a distributed fashion leveraging on the accelerated distributed augmented Lagrangian method, showing sufficient conditions for guaranteeing convergence. The proposed model predictive control approach is validated through numerical simulations under realistic scenarios. </p>
<p><br></p>
<p>This preprint has been accepted for publication in<em> IEEE Transactions on Control Systems Technology</em>. </p>
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<p>This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible </p>
خمرة العشق في شعر ابن الفارض وجلال الدين الرومي
Authors: الفياض حسن , محمد نرجس 
Published: May 2023

يعد النبيذ والشراب من جملة الألفاظ الرمزية الذي أخذت مكانها في شعر ابن الفارض وجلال الدين الرومي فمعاني الخمر وتعابيرها المرتبطة بشرب الخمرة والسكر والساقي يذهب بذهن الشعراء إلى المعشوق الحقيقي والعشق والمحبة الأزلية حيث يصورون من خلالها أجمل الصور الشعرية.
وتناول البحث أمور عدة وهي: الخمرة في شعر ابن الفارض وجلال الدين الرومي، والمضامين الخمرية المشتركة في شعر ابن الفارض وجلال الدين الرومي.
Ice, Ice, Maybe? Investigating 46P/Wirtanen’s Inner Coma for Icy Grains
Authors: Kareta Theodore , Noonan John W. , Harris Walter M. , Springmann Alessondra 
Published: May 2023

Abstract
The release of volatiles from comets is usually from direct sublimation of ices on the nucleus, but for very or hyperactive comets other sources have to be considered to account for the total production rates. In this work, we present new near-IR (NIR) imaging and spectroscopic observations of 46P/Wirtanen taken during its close approach to Earth on 2018 December 19 with the MMIRS instrument at the MMT Observatory to search for signatures of icy or ice-rich grains in its inner coma that might explain its previously reported excess water production. The morphology of the images does not suggest any change in grain properties within the field of view, and the NIR spectra do not show the characteristic absorption features of water ice. Using a new Markov Chain Monte Carlo–based implementation of the spectral modeling approach of Protopapa et al., we estimate the areal water ice fraction of the coma to be <0.6%. When combined with slit-corrected Af
ρ values for the J, H, and K bands and previously measured dust velocities for this comet, we estimate an icy grain production rate of less than 4.6 kg s−1. This places a strict constraint on the water production rate from pure icy grains in the coma, and in turn we find that for the 2018–2019 apparition approximately 64% of 46P’s surface was actively sublimating water near perihelion. We then discuss 46P’s modern properties within the context of other (formerly) hyperactive comets to understand how these complex objects evolve.
The roles of churches in HIV prevention among youth at Nqutu in KwaZulu-Natal South Africa
Authors: Madlala Siphiwe T. , Khanyile Sethembile 
Published: May 2023

Background: Human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) is a crisis of massive economic, social, spiritual, as well as political magnitudes. Joint United Nations Programme on HIV/AIDS (UNAIDS) revealed that in 2018, there were 37.9 million individuals across the globe who lived with HIV and/or AIDS. The religion is an essential tool used by the pastors to help people living with HIV to come to terms with the illness. Therefore, it is imperative that religious leaders should be actively involved in the prevention of HIV epidemic among the youth.Objectives: The study objective was to explore and describe the roles of churches in HIV prevention among youth at Nqutu in KwaZulu-Natal.Method: A qualitative descriptive phenomenology design was employed. Data were collected from 18 to 35 years old participants who were purposefully sampled. Unstructured interviews were conducted to collect data, which was determined by saturation and analysed using Colaizzi’s method of data analysis.Results: The study revealed five major themes, which consisted of churches’ contribution to HIV prevention; health awareness; churches’ involvement in sexual education; churches’ partnership with stakeholders, human and financial resources. It became evident that churches’ contribution to HIV and/or AIDS prevention is beneficial to the youth.Conclusion: The study’s findings revealed that churches play a significant role in HIV prevention among youths. Programmes available in churches play an important role among the youth in curbing the HIV epidemic.Contribution: The Department of Health should consider collaborating with church leaders to promote and prevent HIV and/or AIDS among youth.