bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing surimi gelling properties and natural additive–based gel fortification strategies: A review
Authors: Yang Ruizhi , Juma Nasra Seif , Zhao Yadong , Zheng Bin , Xu Yan , Gao Yuanpei , Jia Ru , Gao Pingping , He Yanhong 
Published: January 2025

AbstractGelation and gel properties are crucial to surimi‐based seafood products, and many factors significantly influence surimi gel quality. Although physical and chemical modifications can improve surimi gel performance, challenges such as high cost, difficulties in industrialization and environmental pollution pose significant barriers to their practicality. Natural additives offer a promising alternative by reinforcing and improving the characteristics of surimi gel through mechanisms such as protein conformational transformation, protein denaturation, and altered chemical forces. By incorporating different substances into surimi gel, it is possible to tune the interaction between the additives and the myofibrillar proteins, thus enhancing the gelation process and achieving the desired textural profiles. This review comprehensively explored the factors influencing the surimi gelation chemistry, with a focus on how the natural additives such as proteins, lipids, polysaccharides, salts, enzymes, and extracts impact the surimi gel properties. It elucidated the reinforcing mechanisms of these additives and proposed a general interaction model between natural substance and myofibrillar proteins. Furthermore, this review well established the interrelation between the performance and mechanism of enhancement effects of typical natural substances on surimi gels and provided new insights on tuning surimi gelation and gel properties by adding natural additives with specific physicochemical properties, thus facilitating the production of high‐quality surimi products with satisfactory gel characteristics in food industry.
Long‐range trajectory reconstructions using the point mass model
Authors: Riva Fabiano , Broekhuis Frederick Richard , Haag Michael , Koene Lambertus , Kerkhoff Wim 
Published: January 2025

AbstractIn shooting incident reconstructions, forensic examiners usually deal with scenes involving short‐range trajectories, typically ≤30 m. In situations such as this, a linear trajectory reconstruction model is appropriate. However, a forensic expert can also be asked to estimate a shooter's position by reconstructing a long‐range trajectory where the bullet's path becomes arced as a result of gravity and the greater time in flight. In this study, the point mass model (PMM) was used, because it is accessible and considered sufficiently accurate. A computer program using PMM can perform long‐range trajectory reconstructions starting from an impact point. The reconstruction results in an area where the shot is expected to be fired from, not a single location. This is caused by varying the input parameters of the PMM. The aim of this study is to assess the accuracy of the method and discuss the influence of the most relevant parameters. The model has been validated by comparing its performance with 20 handgun bullet trajectories that were determined using Doppler radar measurements over long ranges, i.e. from 500 m to 1800 m. Comparison between the area calculated using the model and the actual shooter position demonstrates the limits of these reconstructions, particularly at high incident angles. The differences between the reconstructed deflections and the deflections measured by the tracking radar are rather large. This phenomenon is caused by either measurement errors in the cross wind as a function of height or inaccuracy of the radar's deflection measurements.
Exploring the conceptual history of validity in nursing diagnoses: A Koselleckian perspective
Authors: de Oliveira Lopes Marcos Venicios , da Silva Viviane Martins 
Published: January 2025

AbstractPurposeThis purpose of this article was to use the method of conceptual history to analyze the evolution of the concept of “validity” in nursing diagnoses and to identify key transformations, theoretical influences, and implications for contemporary clinical judgment and decision‐making.MethodsFive stages derivate from the approach proposed by Reinhart Koselleck, including: identify the concept and its relevance, historical contextualization, contextual use, semantic changes over time, and synthesis and interpretation.FindingsThe concept of “validity” in nursing diagnoses is essential for accurate diagnostics, interdisciplinary communication, and evidence‐based decision‐making, though its interpretation varies due to differing philosophical perspectives and methodological challenges. Historically, “validity” in nursing evolved from empirical methods to theory‐driven approaches incorporating psychometric and clinical frameworks. Validation processes have adapted, integrating scientific rigor, ethical considerations, and practical utility, while also reflecting societal, technological, and cultural shifts. Today, the focus is on balancing methodological diversity and evidence‐based practice, with a need for continuous quality improvement, interdisciplinary collaboration, cultural sensitivity, and patient involvement.ConclusionsThe concept of “validity” in nursing diagnoses has evolved from early empirical methods to its current focus on evidence‐based practices, interdisciplinary integration, and cultural sensitivity, emphasizing the need for accurate, technologically informed diagnostics to enhance patient care and guide clinical decision‐making.Implications for nursing practiceNursing must integrate diverse perspectives, cultural sensitivity, and technology into its diagnoses, and professionals should be trained in both scientific and ethical aspects to improve patient outcomes.
Peri‐operative mental health interventions for surgical oncology patients: a narrative synthesis and meta‐analysis
Authors: Abraham Joanna , Holzer Katherine J. , Pedamallu Lavanya , Kozower Benjamin D. , Avidan Michael S. , Lenze Eric J. 
Published: January 2025

SummaryIntroductionOncologic surgeries are common and rates of depression and anxiety are high in the peri‐operative period, potentially interfering with successful recovery.MethodsWe conducted a narrative review and meta‐analysis focusing on randomised controlled trials evaluating the effect of peri‐operative mental health interventions on anxiety and/or depression in adult patients having oncological surgery. The review included studies published in the last 5 years, identified through EMBASE with no pre‐specified criteria for the type of comparison or outcome. A meta‐analysis using a random effects model was performed for outcomes with sufficient data, and a vote‐counting synthesis was performed for studies with insufficient data or fewer than two studies per outcome.ResultsSeventeen randomised controlled trials were included. All were conducted internationally, primarily in Asia. Ten studies assessed psychological interventions (e.g. cognitive behavioural therapy), six assessed pharmacological interventions (e.g. ketamine) and one assessed acupuncture. Meta‐analysis revealed significant intervention effects on pre‐operative anxiety scores (n = 429, Hedge's g = ‐1.03, p = 0.001) and postoperative depression scores at hospital discharge (n = 188, Hedge's g = ‐0.88, p < 0.001), whereas no significant intervention effect was found in anxiety scores at discharge (n = 188, Hedge's g = ‐1.54, p = 0.08). Vote‐counting synthesis identified intervention effects on depression and anxiety scores on day 3 postoperatively and on depression scores at one‐week postoperatively, while all other time‐points showed no intervention effect.DiscussionPsychological and pharmacological interventions are effective at reducing pre‐operative anxiety and immediate postoperative depression scores in patients having oncological surgery, but these benefits do not persist postoperatively. Hence, future research efforts should focus on development and testing of interventions that are effective and implementable within the peri‐operative context.
Anaesthetic management of oncological disease in pregnancy: a narrative review
Authors: Sharif Ben , Nana Melanie , Kearns Rachel , Lo Queenie , Metodiev Yavor 
Published: January 2025

SummaryIntroductionCancer complicates approximately 1 in 2000 pregnancies, with increasing incidence due to factors such as increased maternal age, obesity and advancements in antenatal testing. Anaesthetists play a crucial role in managing pregnant patients with cancer, both during delivery and in providing anaesthesia for oncological treatments. This review explores the challenges in anaesthetic management and specific considerations for common cancers encountered in pregnant patients.MethodsAn electronic literature search was carried out using PubMed and Google Scholar to identify peer‐reviewed articles published in English from 1 January 1990 to 30 July 2024.ResultsTwo main areas were identified: anaesthetic management related to pregnancy and the peripartum period in patients with cancer; and oncological management during pregnancy. Current data suggest that pregnancy does not worsen cancer prognosis, but diagnosis and treatment are complicated by the overlap of cancer symptoms with physiological changes of pregnancy and concerns about the safety of diagnostic procedures and treatments. Ultrasound and magnetic resonance imaging are preferred imaging modalities, while careful use of ionising radiation is advised. Treatment during pregnancy, including surgery, chemotherapy and radiotherapy is possible, with specific timing and modality considerations to ensure maternal and fetal safety. Anaemia, poor nutrition and preterm birth are significant concerns in managing pregnant patients with cancer. For operative births, neuraxial techniques are preferred, though general anaesthesia may be required in complex cases. Comprehensive multidisciplinary support, including psychosocial care, is essential for optimal outcomes. Oncological surgery during pregnancy should preferably be scheduled for the second trimester, with consideration for fetal monitoring and steroids. Regional anaesthesia should be utilised if possible and uteroplacental perfusion maintained. Increased risks of thromboembolism should be addressed postoperatively, along with psychological support.DiscussionEffective and safe anaesthetic management of cancer in pregnancy requires a multidisciplinary approach to balance maternal and fetal safety, with a focus on careful planning and individualised care.
Cardiotoxicity and peri‐operative considerations in immune checkpoint inhibitor and chimeric antigen receptor T‐cell therapy: a narrative review
Authors: Malode Aishwarya , Makwana Bhargav , Patel Vahin , Khadke Sumanth , Parikh Aneri , Bagga Arindam , Dani Sourbha , Ganatra Sarju 
Published: January 2025

SummaryIntroductionImmunotherapy has transformed cancer treatment, particularly with immune checkpoint inhibitors and chimeric antigen receptor T‐cell therapy. Despite their efficacy, these therapies can induce cardiotoxicity, presenting significant clinical challenges. Immune checkpoint inhibitors can cause myocarditis; pericarditis; arrhythmias; and myocardial infarction through immune‐mediated inflammation. Chimeric antigen receptor T‐cell therapy may result in cardiovascular complications due to cytokine release syndrome, including myocardial dysfunction, endothelial damage and arrhythmias.MethodsWe used PubMed, Embase and Google Scholar to search for peer‐reviewed articles in September 2024 without setting any date limits. Our selection criteria encompassed studies focusing on cardiotoxicity related to immune checkpoint inhibitors or chimeric antigen receptor T‐cell therapy, comprising original research, meta‐analyses, clinical trials and review articles. The findings were reported narratively.ResultsEarly diagnosis of cardiotoxicity is critical but challenging due to non‐specific symptoms. Diagnostic tools include ECG; cardiac biomarkers; echocardiography; cardiac magnetic resonance imaging; and endomyocardial biopsy. However, no single tool is definitive. High‐dose corticosteroids are the first‐line treatment for immune checkpoint inhibitor‐induced myocarditis, with additional immunosuppressive therapies for refractory cases. Standard heart failure management protocols should be followed in cases of heart failure. Tocilizumab and corticosteroids are utilised for chimeric antigen receptor T‐cell therapy‐induced cytokine release syndrome, alongside supportive care, including fluid resuscitation and vasopressors for severe cases.DiscussionAs the use of immunotherapy expands, understanding the mechanisms, risk factors and management strategies for cardiotoxicity is increasingly important. Collaborative efforts among oncologists, cardiologists and anaesthetists are essential to mitigate these risks, especially in peri‐operative settings. Ongoing research is vital to improve the safe and effective use of immunotherapeutic drugs while minimising cardiovascular adverse effects.
The evolution and key components of oncoanaesthesia: a narrative review*
Authors: Gupta Raghav , Bhatnagar Sushma 
Published: January 2025

SummaryIntroductionOncoanaesthesia is a specialised branch of anaesthesia dedicated to enhancing outcomes, prioritising patient safety and improving the overall care of patients with cancer during surgery. We outline the global epidemiology of cancer, emphasising the necessity for this subspecialty, and discuss the criteria supporting its establishment.MethodsWe performed searches of electronic databases to identify relevant peer‐reviewed publications. The search was designed to capture a wide range of study types, including randomised controlled trials; retrospective studies; meta‐analyses; and systematic reviews. The titles and abstracts were screened to identify publications relevant to oncoanaesthesia, cancer recurrence and return to intended therapy. The reference lists were manually reviewed to identify relevant papers for consideration.ResultsThis review highlights the growth of oncoanaesthesia over the past decade. Research opportunities abound in areas such as: the impact of anaesthesia on cancer recurrence; the use of enhanced recovery after surgery programmes; patient blood management; peri‐operative nutrition; techniques for modulating peri‐operative inflammatory responses; and strategies to reduce the time to return to intended oncological treatment.DiscussionBy integrating various subspecialties within oncology centres, oncoanaesthesia ensures a thorough and holistic approach to both curative and palliative cancer care, ultimately improving patient outcomes and providing better support for families and caregivers throughout the peri‐operative period.
Association between peri‐operative red blood cell transfusion and cancer recurrence in patients undergoing major cancer surgery: an umbrella review*
Authors: Etheridge Joshua , Shah Panth , Stanworth Simon J. , Harrison Ewen , Gillies Michael , Walsh Timothy S. , Shah Akshay 
Published: January 2025

SummaryIntroductionPeri‐operative allogeneic red blood cell transfusion is hypothesised to increase the risk of cancer recurrence following cancer surgery. However, previous data supporting this association are limited by residual confounding. We conducted an umbrella review (i.e. a systematic review of systematic reviews) to synthesise and evaluate the evidence between red blood cell transfusion and cancer recurrence.MethodsWe searched online databases for systematic reviews of red blood cell transfusion and cancer‐related outcomes. The AMSTAR 2 tool was used for quality assessment. The adequacy of confounding adjustment was judged according to a consensus‐derived framework.ResultsWe included five relevant systematic views which included patient populations ranging from 2110 to 184,190. Two reviews reported cancer recurrence, and all reported an association with red blood cell transfusion. Three reviews reported positive associations between red blood cell transfusion and adverse outcomes including all‐cause mortality, recurrence‐free survival and cancer‐related mortality. According to AMSTAR 2, four reviews were rated as ‘critically low quality’ and one as ‘low quality’. There was variation in how systematic reviews assessed the risk of bias from confounding. Compared with our pre‐derived framework, we found a high likelihood of unmeasured confounding.DiscussionCurrently available evidence describes an association between peri‐operative red blood cell transfusion and cancer recurrence, but this is mostly of low to critically low quality, with minimal control for residual confounding. Further research, at low risk of bias, is required to provide definitive evidence and inform practice.
Optimisation of the patient having oncological surgical through prehabilitation: a narrative review
Authors: Moore John , Beaney Alec , Humphreys Liam , Merchant Zoe , Parmar Krishna Kholia , Levett Denny 
Published: January 2025

SummaryIntroductionPrehabilitation aims to improve physiological reserve and psychological resilience, enabling patients to better tolerate the physiological stress of major surgery, thereby reducing the risk of complications and improving surgical outcomes. In this review, we provide an update of the development of prehabilitation in patients having cancer surgery.MethodsWe searched databases of peer‐reviewed research to identify appropriate papers. Keywords comprised ‘prehabilitation’, ‘cancer surgery’ and associated synonyms (prehab; pre‐operative rehabilitation; cancer). The results were combined with articles identified by reviewing the references of key papers and the use of the grey literature to develop our discussion.ResultsWe detail the different elements of prehabilitation (exercise, nutrition, psychological support) relevant to patients with cancer undergoing surgery, focusing on the recent evidence base and ongoing challenges. Within this, we consider the role of behaviour change in enabling patients to undertake prehabilitation interventions and reflect on the different models of prehabilitation that have been utilised. Facilitators and barriers to implementation of prehabilitation are explored. Key findings include positioning prehabilitation as an integral part of the oncological surgical pathway which includes, but is discrete from, medical optimisation.DiscussionPrehabilitation has the potential to improve surgical outcomes for patients undergoing cancer surgery. Further evidence is needed to understand how and what we provide to patients as optimal exercise, nutrition and psychological interventions as part of their surgical care, and how we improve long‐term lifestyle using behaviour change methodology. Digital technology offers the opportunity for scaling and greater personalisation of prehabilitation but needs to be deliberately fashioned to ensure equitable access.
Return to intended oncological therapy following advanced ovarian cancer surgery: a narrative review
Authors: Tse Ka Yu , Chu Mandy Man Yee , Chiu Jessie Wan Kam , Kwok Shuk Tak , Irwin Michael G. , Chan Aaron Hey Yin , Ho Polly , Cheng Calvin Pak Wing , Ngu Siew Fei , Chan Karen Kar Loen 
Published: January 2025

SummaryIntroductionPatients with advanced ovarian cancer often require radical cytoreductive surgery and chemotherapy, with or without targeted therapy. Return to intended oncological therapy after surgery is a crucial metric, as delay can worsen survival. The concept of return to intended oncological therapy is important because it highlights the need for not just successful surgical outcomes, but also the ability to continue with the comprehensive cancer treatment plan.MethodsA comprehensive review of the literature was conducted to identify relevant English language studies published from January 2010 to September 2024.ResultsDelayed return to intended oncological therapy after surgery was associated with poor survival outcomes in ovarian cancer. This narrative review investigates how pre‐operative counselling and education; optimisation of the patient's medical condition; meticulous surgical planning and execution; early recognition of complications; and comprehensive postoperative care influence return to intended therapy in gynaecological surgery. Effective multidisciplinary care involving anaesthetists; nurses; physiotherapists; dietitians; psychologists; and the patient's relatives or friends, can prevent complications and ensure timely return to intended oncological therapy.DiscussionAwareness and management of factors affecting return to intended oncological therapy are essential for improving outcomes in patients with advanced ovarian cancer. We highlight the importance of multidisciplinary care (including enhanced recovery after surgery programmes) and the factors affecting these including age; nutrition; and occurrence of postoperative complications.
Prevalence and outcomes of patients taking oral corticosteroids for over 1 month undergoing major surgery in England 2010–2020
Authors: Harris Jessica , Russell Georgina , Reeves Barnaby , Gibbison Ben 
Published: January 2025

SummaryIntroductionApproximately 1% of the UK population is prescribed oral corticosteroids at any one time. It is not known how many of these patients present for major surgery. We aimed to establish the prevalence, characteristics and outcomes of patients taking oral corticosteroids.MethodsWe identified patients aged > 18 y undergoing major surgery between 1 April 2010 and 31 March 2020 from Hospital Episode Statistics with linked Clinical Practice Research Datalink data and the Office for National Statistics Mortality register in England. Prescribing data were used to define three sets of patients: ‘low‐dose’ – taking ≤ 7.5 mg oral prednisolone equivalents per day for at least 28/91 days before surgery; ‘high‐dose’ – taking > 7.5 mg oral prednisolone equivalents per day for at least 28/ 91 days before surgery; and a ‘no‐steroids’ group. We used ≤ 7.5 mg of prednisolone equivalents per day as our threshold, as this would likely exclude almost all patients who were taking corticosteroids as replacement for absolute adrenal/pituitary deficiency.ResultsWe identified 1,999,326 adult patients for inclusion in the dataset: 1,929,291 (96.5%) in the no‐steroids; 63,353 (3.2%) in the low‐dose group; and 6682 (0.3%) in the high‐dose group. Median (IQR [range]) duration of hospital stay increased with increasing dose of corticosteroid (no‐steroid 3 (0–14 [0–14,739]); low‐dose 5 (1–26 [1–8079]); and high‐dose 7 (2–28 [0–6956]) days). Mortality after the index surgery was 1.5%, 3.8% and 8.9% at 30 days and 5.5%, 11.6% and 39.9% at 1 year for no‐steroids, low‐dose and high‐dose groups, respectively.ConclusionAround 1 in 29 patients undergoing major surgery are taking oral corticosteroids for > 28 days in the 3 months before major surgery. Their outcomes are poor and warrant highlighting within care pathways to aid risk prediction and mitigation.