bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of 3D earth pressure with inclined backfill surface considering seismic loads and suction effects
Authors: Wang Long , Hu Wei , Gao You , Zhou Enquan , Li Jie , Chen Guoxing 
Published: February 2023

AbstractEarthquake remains the main factor in triggering the slope failures and the rigid gravity retaining wall is an effective technique in guaranteeing the slope safety. In earth pressures estimations, considering simultaneously the three‐dimensional (3D) features of backfills, the suction‐induced effects and the dynamic characteristics of seismic excitations warrants producing more realistic solutions. In the category of upper bound limit analysis theorem, a modified semi‐analytical method for determining the seismic earth pressures of inclined unsaturated backfills is provided. Applicability and reliability of this method is varied through comparisons and the seismic responses of 3D inclined unsaturated backfills are studied. The results indicate that the 3D effect relates closely to the seismic excitations and the SWCC and can hardly be ignored in earth pressure estimations. The 3D effect varies periodically as the seismic wave propagates and is more evident in fine‐grain soil slopes but is relatively less obvious in coarse‐grain soil slopes.
Haemodialysis nurses' occupational health and work‐related musculoskeletal hand pain after work: A cluster analysis
Authors: Westergren Eva , Lindberg Magnus 
Published: February 2023

AbstractAimTo identify clusters based on haemodialysis nurses' self‐rated work ability, work engagement and self‐reported work hours and to compare the identified clusters regarding hand pain after work.DesignCross‐sectional survey.MethodsData based on the Work Ability Index, Utrecht Work Engagement Scale and hand pain severity after work were collected through a web‐based survey among 503 haemodialysis nurses working in Sweden and Denmark. A two‐step cluster analysis was used to identify homogenous groups of cases within the dataset, followed by comparative analyses of the clusters.ResultsFour distinct clusters were identified, illustrating differing profiles of haemodialysis nurses' work ability, work engagement and working hours. Nurses who worked part‐time and reported moderate work ability and average work engagement had significantly higher ratings of hand pain after work.ConclusionsHaemodialysis nurses are a heterogeneous group as regards work ability, work engagement and self‐reported work hours. The four distinct clusters of nurses indicate a need for customized interventions for retaining each subgroup at work.
Optimization of Charpy‐impact strength of 3D‐printed carbon fiber/polyamide composites by Taguchi method
Authors: Beylergil Bertan , Al‐Nadhari Abdulrahman , Yildiz Mehmet 
Published: February 2023

AbstractThis study utilizes the Taguchi optimization technique to investigate the effects of FDM processing parameters on the Charpy impact strength of 3D printed CF/PA composites experimentally and statistically. The four 3D printing parameters employed in the experiment are the infill density, raster angle, extruder temperature, and printing speed, which were used to create the experimental plan with the L18 orthogonal array. Signal to noise (S/N) ratios and analysis of variance (ANOVA) were utilized to identify the optimum values and the interactions between the process parameters. SEM and thermography techniques were employed to assess the microstructural and damage status of the CF/PA composite specimens. ANOVA results determined that only three factors–infill density, raster angle, and extruder temperature–had a statistical significance, while printing speed did not. The outcomes demonstrated that the optimal 3D printing parameters are infill density (100%), raster angle (60°), extruder temperature (260°C), infill density (100%), and printing speed (30 mm/s), with the maximum contribution of 54.19% belonging to infill density, and the minimum contribution of 2.84% belonging to printing speed. The optimal combination of these 3D printing parameters yielded a Charpy impact strength of 10.54 kJ/m2, resulting in an increase of almost 150% compared to the worst‐case situation. The Taguchi approach proves to be a proficient technique to boost the Charpy impact strength of 3D‐printed CF/PA composites.
Label‐free single cell proteomics utilizing ultrafast LC and MS instrumentation: A valuable complementary technique to multiplexing
Authors: Matzinger Manuel , Mayer Rupert L. , Mechtler Karl 
Published: February 2023

AbstractThe ability to map a proteomic fingerprint to transcriptomic data would master the understanding of how gene expression translates into actual phenotype. In contrast to nucleic acid sequencing, in vitro protein amplification is impossible and no single cell proteomic workflow has been established as gold standard yet. Advances in microfluidic sample preparation, multi‐dimensional sample separation, sophisticated data acquisition strategies, and intelligent data analysis algorithms have resulted in major improvements to successfully analyze such tiny sample amounts with steadily boosted performance. However, among the broad variation of published approaches, it is commonly accepted that highest possible sensitivity, robustness, and throughput are still the most urgent needs for the field. While many labs have focused on multiplexing to achieve these goals, label‐free SCP is a highly promising strategy as well whenever high dynamic range and unbiased accurate quantification are needed. We here focus on recent advances in label‐free single‐cell mass spectrometry workflows and try to guide our readers to choose the best method or combinations of methods for their specific applications. We further highlight which techniques are most propitious in the future and which applications but also limitations we foresee for the field.
Incidence and risk factors for patellofemoral dislocation in adults with Charcot‐Marie‐Tooth disease: An observational study
Authors: Leone Enza , Davenport Sally , Robertson Claire , Laurà Matilde , Skorupinska Mariola , Reilly Mary M. , Ramdharry Gita 
Published: February 2023

AbstractBackground and PurposePatellofemoral (PF) dislocation is frequently encountered in clinical practice among people with Charcot‐Marie‐Tooth disease (CMT), but the frequency and risk factors for PF dislocation in adults with CMT are unknown. This study aimed to establish the incidence of PF dislocation in adults with CMT and to explore the risk factors associated with PF dislocation.MethodsThis is a cross‐sectional study involving adults with a diagnosis of CMT, attending their outpatient clinics at a specialist neuromuscular centre in the United Kingdom. Eighty‐one individuals were interviewed about any PF dislocation and underwent a lower‐limb assessment, with a focussed knee examination, to identify possible risk factors for PF dislocation. The incidence of PF dislocation was expressed as a percentage (number of individuals with a positive history of patellar dislocation/overall sample) and the association between different risk factors and PF dislocation was explored using logistic regression analysis.ResultsThe incidence of PF dislocation was 22.2% (18/81). PF dislocation was associated with a younger age at the time of the assessment (p = 0.038) and earlier disease onset (p = 0.025). All people bar two who dislocated had CMT1A (88.9%), but there was no difference in terms of CMT distribution with the non‐dislocation group (p = 0.101). No association was found between PF dislocation and CMT severity measured by CMTSS (p = 0.379) and CMTES (p = 0.534). Patella alta (p = 0.0001), J‐sign (p = 0.004), lateral patellar glide (p = 0.0001), generalised joint hypermobility (p = 0.001) and knee flexors weakness (p = 0.008) were associated with an increased risk of dislocation. Patella alta (p = 0.010) and lateral patellar glide (p = 0.028) were independent PF dislocation predictors.ConclusionsPF dislocation was common in this cohort with CMT and was associated with multiple risk factors. Future studies should be conducted to confirm the present findings so that the identified risk factors may be addressed by clinicians through preventive, supportive and corrective measures.
Study of Charged Anisotropic Karmarkar Stars in f(R,T2)$f(\mathcal {R},\mathbb {T}^{2})$ Theory
Authors: Sharif M. , Gul M. Zeeshan 
Published: February 2023

AbstractThis paper examines the viable attributes of charged compact stars with anisotropic matter configuration in theory. For this purpose, we use the embedding class‐1 technique and consider a specific functional form of this modified theory, i.e, to examine the geometry of compact objects. The values of unknown parameters are found by the smooth matching of interior (static spherical metric) and exterior (Reissner‐Nordstrom metric of energy‐momentum squared gravity) spacetimes. We investigate the impact of effective fluid parameters anisotropy, equation of state parameters and energy bounds in the inner region of the charged stellar objects. The stability of the stellar models in the presence of charge is examined by speed of sound and adiabatic index. We find that embedding class‐1 solution is physically viable and stable for charged anisotropic stellar objects in this modified theory.
Emerging antibacterial nanozymes for wound healing
Authors: Shan Jingyang , Che Junyi , Song Chuanhui , Zhao Yuanjin 
Published: February 2023

AbstractWound infections continuously impose a huge economic and social burden on public healthcare. Despite the effective treatment of bacteria‐infected wounds after using traditional antibiotics, the misuse of antibiotics usually causes the spread of bacterial resistance and decreases therapeutic outcomes. Therefore, the development of efficient antibacterial agents is urgently needed. Nanozymes, as a new generation of artificial enzymes, combine the intrinsic abilities of nanomaterials and natural enzymes. Recently, nanozymes has been widely developed to kill bacteria and treat wound infections by catalyzing the generation of various reactive oxygen species. Thus, this new concept of “antibacterial nanozymes” will promote the further advances of connecting nanozymes and bacterial elimination. To highlight these achievements, we summarize different types of antibacterial nanozymes for wound healing. It is believed that such a promising therapeutic strategy of developing antibacterial nanozymes will make a great contribution in the field of skin regeneration. We expect that antibacterial nanozymes will play the significant roles in both basic research and clinical applications.
Smart One‐for‐All Agent with Adaptive Functions for Improving Photoacoustic /Fluorescence Imaging‐Guided Photodynamic Immunotherapy
Authors: Gao Heqi , Qi Xinwen , Zhang Jingtian , Wang Nan , Xin Jingrui , Jiao Di , Liu Kaining , Qi Ji , Guan Yong , Ding Dan 
Published: February 2023

AbstractMultifunctional phototheranostics that integrate several diagnostic and therapeutic strategies into one platform hold great promise for precision medicine. However, it is really difficult for one molecule to possess multimodality optical imaging and therapy properties that all functions are in the optimized mode because the absorbed photoenergy is fixed. Herein, a smart one‐for‐all nanoagent that the photophysical energy transformation processes can be facilely tuned by external light stimuli is developed for precise multifunctional image‐guided therapy. A dithienylethene‐based molecule is designed and synthesized because it has two light‐switchable forms. In the ring‐closed form, most of the absorbed energy dissipates via nonradiative thermal deactivation for photoacoustic (PA) imaging. In the ring‐open form, the molecule possesses obvious aggregation‐induced emission features with excellent fluorescence and photodynamic therapy properties. In vivo experiments demonstrate that preoperative PA and fluorescence imaging help to delineate tumors in a high‐contrast manner, and intraoperative fluorescence imaging is able to sensitively detect tiny residual tumors. Furthermore, the nanoagent can induce immunogenic cell death to elicit antitumor immunity and significantly suppress solid tumors. This work develops a smart one‐for‐all agent that the photophysical energy transformation and related phototheranostic properties can be optimized by light‐driven structure switch, which is promising for multifunctional biomedical applications.
Module intersection and uniform formula for iterative reduction of one-loop integrals
Authors: Chen Jiaqi , Feng Bo 
Published: February 2023

Abstract
In this paper, we develop an iterative sector-level reduction strategy for Feynman integrals, which bases on module intersection in the Baikov representation and auxiliary vector for tensor structure. Using this strategy we have studied the reduction of general one-loop integrals, i.e., integrals having arbitrary tensor structures and arbitrary power for propagators. Inspired by these studies, a uniform and compact formula that iteratively reduces all one-loop integrals has been written down, where messy polynomials in integration-by-parts (IBP) relations have organized themselves to Gram determinants.
Transfer of Energy from Flexural to Torsional Modes for the Fish-Bone Suspension Bridge Model
Authors: Marchionna Clelia , Panizzi Stefano 
Published: February 2023

AbstractWe consider a conservative coupled oscillators system which arises as a simplified model of the interaction of flexural and torsional modes of vibration along the deck of the so-called fish-bone (Berchio and Gazzola in Nonlinear Anal 121:54–72, 2015) model of suspension bridges. The elastic response of the cables is supposed to be asymptotically linear under traction, and asymptotically constant when compressed (a generalization of the slackening regime). We show that for vibrations of sufficiently large amplitude, transfer of energy from flexural modes to torsional modes may occur provided a certain condition on the parameters is satisfied. The main result is a non-trivial extension of a theorem in Marchionna and Panizzi (Nonlinear Anal 140:12–28, 2016) to the case when the frequencies of the normal modes are no more supposed to be the same. Several numerical computations of instability diagrams for various slackening models respecting our assumptions are presented.
CAD-based data augmentation and transfer learning empowers part classification in manufacturing
Authors: Ruediger-Flore Patrick , Glatt Moritz , Hussong Marco , Aurich Jan C. 
Published: February 2023

AbstractEspecially in manufacturing systems with small batches or customized products, as well as in remanufacturing and recycling facilities, there is a wide variety of part types that may be previously unseen. It is crucial to accurately identify these parts based on their type for traceability or sorting purposes. One approach that has shown promising results for this task is deep learning–based image classification, which can classify a part based on its visual appearance in camera images. However, this approach relies on large labeled datasets of real-world images, which can be challenging to obtain, especially for parts manufactured for the first time or whose appearance is unknown. To overcome this challenge, we propose generating highly realistic synthetic images based on photo-realistically rendered computer-aided design (CAD) data. Using this commonly available source, we aim to reduce the manual effort required for data generation and preparation and improve the classification performance of deep learning models using transfer learning. In this approach, we demonstrate the creation of a parametric rendering pipeline and show how it can be used to train models for a 30-class classification problem with typical engineering parts in an industrial use case. We also demonstrate how our method’s entropy gain improves the classification performance in various deep image classification models.
Emergence of mass spectrometry detergents for membrane proteomics
Authors: Behnke Jan-Simon , Urner Leonhard H. 
Published: February 2023

AbstractDetergents enable the investigation of membrane proteins by mass spectrometry. Detergent designers aim to improve underlying methodologies and are confronted with the challenge to design detergents with optimal solution and gas-phase properties. Herein, we review literature related to the optimization of detergent chemistry and handling and identify an emerging research direction: the optimization of mass spectrometry detergents for individual applications in mass spectrometry–based membrane proteomics. We provide an overview about qualitative design aspects including their relevance for the optimization of detergents in bottom-up proteomics, top-down proteomics, native mass spectrometry, and Nativeomics. In addition to established design aspects, such as charge, concentration, degradability, detergent removal, and detergent exchange, it becomes apparent that detergent heterogeneity is a promising key driver for innovation. We anticipate that rationalizing the role of detergent structures in membrane proteomics will serve as an enabling step for the analysis of challenging biological systems.
Gamma radiation coupled ADP-ribosyl transferase activity of Pseudomonas aeruginosa PE24 moiety
Authors: Morgan Radwa N. , Saleh Sarra E. , Farrag Hala A. , Aboshanab Khaled M. 
Published: February 2023

Abstract

The ADP-ribosyl transferase activity of P. aeruginosa PE24 moiety expressed by E. coli BL21 (DE3) was assessed on nitrobenzylidene aminoguanidine (NBAG) and in vitro cultured cancer cell lines. Gene encoding PE24 was isolated from P. aeruginosa isolates, cloned into pET22b( +) plasmid, and expressed in E. coli BL21 (DE3) under IPTG induction. Genetic recombination was confirmed by colony PCR, the appearance of insert post digestion of engineered construct, and protein electrophoresis using sodium dodecyl-sulfate polyacrylamide gel (SDS-PAGE). The chemical compound NBAG has been used to confirm PE24 extract ADP-ribosyl transferase action through UV spectroscopy, FTIR, c13-NMR, and HPLC before and after low-dose gamma irradiation (5, 10, 15, 24 Gy). The cytotoxicity of PE24 extract alone and in combination with paclitaxel and low-dose gamma radiation (both 5 Gy and one shot 24 Gy) was assessed on adherent cell lines HEPG2, MCF-7, A375, OEC, and Kasumi-1 cell suspension. Expressed PE24 moiety ADP-ribosylated NBAG as revealed by structural changes depicted by FTIR and NMR, and the surge of new peaks at different retention times from NBAG in HPLC chromatograms. Irradiating recombinant PE24 moiety was associated with a reduction in ADP-ribosylating activity. The PE24 extract IC50 values were < 10 μg/ml with an acceptable R2 value on cancer cell lines and acceptable cell viability at 10 μg/ml on normal OEC. Overall, the synergistic effects were observed upon combining PE24 extract with low-dose paclitaxel demonstrated by the reduction in IC50 whereas antagonistic effects and a rise in IC50 values were recorded after irradiation by low-dose gamma rays.

Key points
• Recombinant PE24 moiety was successfully expressed and biochemically analyzed.
• Low-dose gamma radiation and metal ions decreased the recombinant PE24 cytotoxic activity.
• Synergism was observed upon combining recombinant PE24 with low-dose paclitaxel.
Prevalence of celiac artery compression by median arcuate ligament in patients with splanchnic artery aneurysms/pseudoaneurysms submitted to endovascular embolization
Authors: Borges Ana Paula , Antunes Célia , Donato Paulo 
Published: February 2023

Abstract
Purpose
To study the association between median arcuate ligament compression (MALC) of celiac artery (CA) and splanchnic artery aneurysms/pseudoaneurysms (SAAPs) submitted to endovascular embolization.

Methods
Single center retrospective study of embolized SAAPs between 2010 and 2021, to evaluate the prevalence of MALC, and compare demographic data and clinical outcomes between patients with and without MALC. As a secondary objective, patient characteristics and outcomes were compared between patients with different causes of CA stenosis.

Results
MALC was found in 12.3% of 57 patients. SAAPs were more prevalent in the pancreaticoduodenal arcades (PDAs) in patients with MALC, compared to those without MALC (57.1% vs. 10%, P = .009). Patients with MALC had a greater proportion of aneurysms (71.4% vs. 24%, P = .020), as opposed to pseudoaneurysms. Rupture was the main indication for embolization in both groups (71.4% and 54% of patients with and without MALC, respectively). Embolization was successful in most cases (85.7% and 90%), with 5 immediate (28.6% and 6%) and 14 non-immediate (28.6% and 24%) post-procedure complications. Thirty and 90-day mortality rate were 0% in patients with MALC, and 14% and 24% in patients without MALC. Atherosclerosis was the only other cause of CA stenosis, in 3 cases.

Conclusions
In patients with SAAPs submitted to endovascular embolization, the prevalence of CA compression by MAL is not uncommon. The most frequent location for aneurysms in patients with MALC is in the PDAs. Endovascular management of SAAPs is very effective in patients with MALC, with low complications, even in ruptured aneurysms.

Graphical Abstract
Pediatric Trauma in The Netherlands: Incidence, Mechanism of Injury and In‐Hospital Mortality
Authors: Fylli Christina , Schipper Inger B. , Krijnen Pieta 
Published: February 2023

AbstractBackgroundIn the Netherlands, there are no specialized or certified pediatric trauma centers, especially for severely injured children. National and regional agreements on centralization of pediatric trauma care are scarce. This study aims to describe the incidence, injury mechanism and in‐hospital mortality of pediatric trauma in the Netherlands, as a prelude to the further organization of pediatric trauma care.MethodsA retrospective cohort analysis of data from the Dutch National Trauma Registry in 2009–2018, concerning all children (0–16 years) hospitalized due to injury in the Netherlands.ResultsThe annual number of admitted injured children increased from 8666 in 2009 to 13,367 in 2018. Domestic accidents were the most common cause of non‐fatal injury (67.9%), especially in children aged 0–5 years (89.2%). Severe injury (injury severity score ≥  16) accounted for 2.5% and 74% of these patients were treated in level‐1 trauma centers. In both deceased and surviving patients with severe injuries, head injuries were the most common (72.1% and 64.3%, respectively). In‐hospital mortality after severe injury was 8.2%. Road‐traffic accidents (RTAs) were the leading cause of death (46.5%).ConclusionsDomestic accidents are the most common cause of injury, especially in younger children, whereas RTAs are the lead cause of fatal injury. Severe pediatric trauma in the Netherlands is predominantly managed in level‐1 trauma centers, where a multidisciplinary team of experts is available. Improving the numbers of severely injured patients primarily brought to level‐1 trauma centers may help to further reduce mortality.