bluuebunny/crossref_metadata_2025_split huggingface dataset:
An online cross-sectional survey of community pharmacists to assess information needs for evidence-based self-medication counselling
Authors: Alexa J. M. , Bertsche T. 
Published: August 2023

Abstract
Background
Community pharmacists play an important role in healthcare. They are frequently visited by patients to receive advice on self-medication products. Little research has been conducted to investigate pharmacists’ information needs for evidence-based self-medication counselling.

Aim
To assess community pharmacists’ information needs in five predefined areas: general and specific individual needs, quality needs, utilisation needs, implication needs, and access needs for evidence based self-medication counselling.

Method
After ethical approval, we conducted an exploratory, semi-quantitative, cross-sectional online survey. Members of three different chambers of pharmacists in Germany were invited to participate anonymously in the survey. They gave informed consent and received no incentive for their participation.
Quantitative outcome: Frequency of relevance / importance of items within predefined information needs areas, except for access needs. Qualitative outcome: Open-text responses concerning all information needs.

Results
We analysed data from a total of 823 participants who completed the survey. General and specific information such as dosage (74.2% [611/823]) and when to refer to a physician (64.6% [532/823]) as well as an over-the-counter product’s effectiveness according to medical guidelines (71.4% [588/823]) were rated as very important. Participants reported to prefer digital information sources (50.5% [416/823] strongly agreed), especially in the form of an easily accessible database (61.6% [507/823] strongly agreed) that contains regularly updated, manufacturer-independent, critically appraised, concise information.

Conclusion
Community pharmacists expressed distinct information needs for evidence-based self-medication counselling. Further information services on essential evidence-based pharmacy knowledge may be necessary to support implementation.
The indirect effect of travel mode use on subjective well-being through out-of-home activities
Authors: Tran Yen , Hashimoto Naohisa , Ando Takafumi , Sato Toshihisa , Konishi Naoki , Takeda Yuji , Akamatsu Motoyuki 
Published: August 2023

AbstractThe issue of the effects of travel on subjective well-being (SWB) has recently attracted increasing interest in transport studies. A common finding is that travel affects SWB indirectly through out-of-home activities. However, little is known about how to operationalize this relationship. In this study, we proposed a conceptual model and estimated structural equation models relating travel mode use and activities with multiple SWB dimensions, including affective components (positive affect and negative affect) and cognitive components (belongingness, achievement, and confidence in coping). We used data from a national mobility project in Japan (N = 13,000) to estimate the postulated models. We found that while public transport use enhanced the cognitive components of SWB, it also had a negative effect on the affective components of SWB. Car use affected SWB in a more complex pattern; it promoted SWB by enabling leisure activities but also reduced SWB dimensions of belongingness and achievement through shopping activities. Active travel modes did not have a clear effect on SWB; for example, walking to school was associated with increased belongingness, whereas walking for shopping negatively influenced belongingness. Other contributing factors, such as COVID-19 worry, car access, and the ‘going-out’ problem-solving style, were also found to influence multiple dimensions of SWB. Overall, our study showed how the effects of activities on multiple dimensions of SWB varied with different travel modes, thereby revealing the indirect effect of travel mode use on SWB via activities. Suggestions for shaping transport policies towards SWB are also discussed.
Living well while providing support: validation of LTCQ-Carer for assessing informal carers’ quality of life
Authors: Potter Caroline M. , Peters Michele , Cundell Maureen , McShane Rupert , Fitzpatrick Ray 
Published: August 2023

Abstract
Purpose
Despite international policies to support the health and wellbeing of informal (family) caregivers, there is no consensus on how to evaluate the effectiveness of carer support. We aimed to develop and validate a new quality-of-life measure for carers (LTCQ-Carer) and to assess its potential for use within a clinical pathway.

Methods
Psychometric properties of LTCQ-Carer were tested through cognitive interviews (qualitative phase) and a pilot survey (quantitative phase). Participants were family caregivers of people recently diagnosed with mild cognitive impairment (MCI) or dementia, recruited through one of 14 memory clinics in south-east England. They self-completed the new measure and comparative existing measures (EQ-5D, ASCOT-Carer). Ongoing feedback from memory clinic staff on potential use of LTCQ-Carer was collected.

Results
Interview participants (n = 10) found all draft items of LTCQ-Carer relevant and prompted inclusion of a new item on ‘time to yourself’. Responses from survey participants (n = 107) indicated acceptability (low missing data), high internal reliability (Cronbach’s α = 0.95), and a general construct (single factor loadings 0.43–0.86 for all items). Observation of predicted associations with EQ-5D and ASCOT-Carer supported construct validity. Responsiveness requires further testing as evidence was inconclusive. Clinical staff feedback on potential use was positive.

Conclusion
LTCQ-Carer is a valid new measure for assessing family caregivers’ quality of life across broad health and social care domains, expanding the range of high-quality tools for evaluating carer support. When used concurrently with patient assessment, it could highlight carer needs and prompt appropriate family support at the earliest point in the clinical pathway.
On the positivity of a certain function related with the Digamma function
Authors: Castillo K. 
Published: August 2023

Abstract
In this note, we prove that

$$\begin{aligned} \left( \frac{x^n}{1-e^{-x}}\right) ^{(n)}>0 \end{aligned}$$

x
n

1
-

e

-
x

(
n
)

>
0

for all

$$x\in (\log 2, \infty )$$

x
∈
(
log
2
,
∞
)

and

$$n\in \mathbb {N}$$

n
∈
N

. This result improves a theorem of Al-Musallam and Bustoz (Ramanujan J 11:399–402, 2006).
Surface Geology of Jupiter’s Trojan Asteroids
Authors: Marchi S. , Bell J. F. , Bierhaus B. , Spencer J. 
Published: August 2023

AbstractThe surface geology of Jupiter’s Trojan asteroids is one of the scientific investigations of the NASALucymission. A dedicated Geology Working Group will implement these studies using primarily panchromatic and color imaging data and complement the interpretation of these data with theoretical models, such as collisional evolution models. TheLucyScience Team will also rely on experience and lessons learned from prior space missions, such as NASA’sNEAR,Dawn, OSIRIS-REx, andNew Horizons.A chief goal of the Geology Working Group is to map craters and characterize their morphology acrossLucytarget’s surfaces over a range of spatial resolutions. These data will be used to constrain the relative and absolute ages of terrains and their impactor size-frequency distributions. More broadly, impact-related processes such as excavation and mass wasting will inform other investigations, including geological unit mapping, stratigraphy and topography, surface composition, and internal structure.Lucy’s cratering data and morphology will also be used to perform comparative analyses with similar data from other small bodies across the Solar System, from Main Belt asteroids to Kuiper Belt objects. The present article provides an overview of the planned activities and methodologies of the Geology Working Group.
OpenMP offloading data transfer optimization for DCUs
Authors: Guo Hengliang , Zhang Long , Zhang Yi , Li Jianan , Xu Xiaoyue , Liu Lu , Cai Kuangsheng , Wu Dan , Yang Shuxin , Kong Lingbo , Gao Xu 
Published: August 2023

AbstractOpenMP supports the use of target offloading compile guidance instructions to invoke heterogeneous-platform accelerators to compute core code segments; however, unreasonable use of target offloading instructions can make the data transfer process time-consuming. The problem of unused array transfer and unused data segment transfer arises when the amount of data transferred from the host side to the device side exceeds the amount of data required for the core computation on the device side. For the transmission of unused arrays, the use of the transmitted arrays is guided by adding a filter to eliminate the transmission of redundant data; for the transmission of unused data segments, the use of arrays is quickly determined on the basis of the filter, and valid data are transmitted by optimizing Clang’s code generation strategy after obtaining the lengths of the data segments in core computation. Experiments are performed using the Polybench benchmark; the optimized speedup for unused array transfer reaches 7%, and the optimized speedup for unused data segment transfer reaches 10%. The experimental results show that data transfer optimization for target offloading characteristics can help improve program performance.
Geographic variation in clinical outcomes and anticoagulation among medicare beneficiaries with non-valvular atrial fibrillation
Authors: Atwater Brett D. , Di Fusco Manuela , Keshishian Allison , Delinger Rachel , Ferri Mauricio , Jiang Jenny , Seigel Lauren , Yuce Huseyin , Guo Jennifer D. 
Published: August 2023

AbstractOral anticoagulants (OACs) have been used to prevent stroke/systemic embolism (SE) among patients with non-valvular atrial fibrillation (NVAF). To evaluate baseline clinical characteristics, incidence rates of stroke/SE and hospitalization for bleeding, and OAC use among elderly patients with NVAF in the US by geographic region. Patients with NVAF were selected from the US Centers for Medicare & Medicaid Services claims database (01JAN2013-31DEC2016). Twelve months of health plan enrollment was required before and after the NVAF diagnosis to evaluate baseline characteristics and outcomes, respectively. Each patient was assigned to a 3-digit zip code based on their primary residence, and geographic variation was visualized using ArcGIS Pro software. Over 2.8 million patients with NVAF were identified. Large geographic variation was observed in clinical characteristics, stroke/SE, hospitalization for bleeding, and OAC use among patients across the US. The zip codes with the highest mean CHA2DS2–VASc scores and frequency of prior bleeding also had the highest incidence of stroke/SE and hospitalization for bleeding. Across 3-digit zip codes, 35–63% of patients were untreated. Overall, the incidence of stroke/SE and hospitalization for bleeding were higher and OAC treatment was less frequent in zip codes located in the Southern US. Baseline clinical characteristics, incidence rates of stroke/SE and hospitalization for bleeding, and OAC usage vary considerably by 3-digit zip code in the US. The additional granularity provided in this study may help clinicians to identify small regions with high-risk of stroke/SE and hospitalization for bleeding and low use of OAC that may benefit from targeted care strategies.
Long-lasting infection with Anaplasma ovis in sheep
Authors: Ruiz Héctor , de Arcaute Marta Ruiz , Benito Alfredo Ángel , Villanueva-Saz Sergio , Jiménez José Calasanz , Lacasta Delia 
Published: August 2023

AbstractOvine anaplasmosis is an emerging vector-borne disease in Europe caused by Anaplasma ovis. The infection has spread quickly in recent years, causing moderate to severe outbreaks in sheep flocks, leading to relevant economic losses in sheep farming. This wider spread has been associated with global warming and climate change, favouring the maintenance and life cycle of their main vector, the ticks. However, another epidemiological aspect could favour this quick spread. Long persistence infection of Anaplasma ovis has been proposed as a hypothesis in several articles but never scientifically proven. The results of the present study demonstrate that eight adult sheep, both naturally or experimentally infected, maintain Anaplasma ovis load in blood during their whole productive life (4 to 6 years), being permanently infected. In addition, the results suggest that A. ovis bacterial load can be constant or suffer fluctuations, as has been demonstrated in other Anaplasma species. Both aspects can be determinants in the epidemiology and the transmission of the infection.
Analysing the Impact of Land Subsidence on the Flooding Risk: Evaluation Through InSAR and Modelling
Authors: Navarro-Hernández María I. , Valdes-Abellan Javier , Tomás Roberto , Tessitore Serena , Ezquerro Pablo , Herrera Gerardo 
Published: August 2023

AbstractFloods greatly impact human settlements in flood risk areas, such as floodplains and coastal lowlands, following heavy rainfall. The Alto Guadalentin valley, an orogenic tectonic depression, experiences extreme flash floods and land subsidence due to groundwater withdrawal, rendering it one of Europe's fastest subsiding regions. In this study, we compared two 2D flood event models representing different land subsidence scenarios for 1992 and 2016. To determine the flooded area and water depth variations due to land subsidence, the Hydrologic Engineering Centre River Analysis System 2D (HEC-RAS 2D) model was used to simulate flood inundation by the Alto Guadalentin River and its tributaries. Synthetic aperture radar (SAR) satellite (ERS, ENVISAT, and Cosmo-SkyMED) images were employed, along with the interferometric SAR (InSAR) technique, to calculate the magnitude and spatial distribution of land subsidence. By analysing the accumulated subsidence distributions obtained from InSAR, the original topography of the valley in 1992 and 2016 was reconstructed. These digital surface models (DSMs) were then used to generate 2D hydraulic models, simulating flood scenarios in the unsteady mode. The results demonstrated significant changes in the water surface elevation over the 14-year period, with a 2.04 km2 increase in areas with water depths exceeding 0.7 m. These findings were utilized to create a flood risk map and assess the economic flood risk. The data highlight the crucial role of land subsidence in determining the inundation risk in the Alto Guadalentin valley, providing valuable insights for emergency management and civil protection against future potential flooding events.
The Parliamentary Inquiry into Mitochondrial Donation Law Reform (Maeve’s Law) Bill 2021 in Australia: A Qualitative Analysis
Authors: Allen Jemima W. , Gyngell Christopher , Koplin Julian J. , Vears Danya F. 
Published: August 2023

AbstractRecently, Australia became the second jurisdiction worldwide to legalize the use of mitochondrial donation technology. The Mitochondrial Donation Law Reform (Maeve’s Law) Bill 2021 allows individuals with a family history of mitochondrial disease to access assisted reproductive techniques that prevent the inheritance of mitochondrial disease. Using inductive content analysis, we assessed submissions sent to the Senate Committee as part of a programme of scientific inquiry and public consultation that informed drafting of the Bill. These submissions discussed a range of bioethical and legal considerations of central importance to the political debate. Significantly, submissions from those with a first-hand experience of mitochondrial disease, including clinicians and those with a family history of mitochondrial disease, were in strong support of this legislation. Those in support of the Bill commended the two-staged approach and rigorous licencing requirements as part of the Bill’s implementation strategy. Submissions which outlined arguments against the legislation either opposed the use of these techniques in general or opposed aspects of the implementation strategy in Australia. These findings offer a window into the ethical arguments and perspectives that matter most to those Australians who took part in the Senate inquiry into mitochondrial donation. The insights garnered from these submissions may be used to help refine policy and guidelines as the field progresses.
Volatility spillovers between oil and financial markets during economic and financial crises: A dynamic approach
Authors: Sánchez García Javier , Cruz Rambaud Salvador 
Published: August 2023

AbstractVolatility in international oil markets is a recurrent phenomenon which causes spillovers on financial markets. However, a bidirectional comparison between the dynamic behavior of economic and financial crises has not been documented yet. This paper addresses this research question by employing a combined GARCH-VAR-Spillover Index methodology to measure the volatility of the WTI and the Brent in order to analyze its relationship with the SP500, NASDAQ, DAX and the IBEX for a sample corresponding to the period [2000:01, 2021:04]. Specifically, this paper compares the dynamic behavior of spillovers during the 2007-2009 financial crisis (taken as the financial crisis) and the COVID-19 pandemic (taken as the economic crisis). It has been found that there exists statistically significant net volatility shocks and spillovers from oil to stocks markets in the majority of cases and periods. These spillovers are bidirectional, and the net relationship is reversed depending on the market and the time period. The dynamic behavior of such spillovers depends on the region, being the USA more reactive to the source of the crisis than Europe. In particular, in the USA when the crisis is originated by financial shocks, financial markets are net transmitters of volatility to oil markets. When the source of the shock is economic, oil markets are net transmitters of volatility to stocks markets. This is not the case for Europe, where financial markets seem to be either transmitters or receivers of volatility no matter the source of the shock. In general, our study offers new evidence to understand macro-financial linkages.
Clinical manifestations of respiratory syncytial virus infection and the risk of wheezing and recurrent wheezing illness: a systematic review and meta-analysis
Authors: Jiang Ming-Yue , Duan Yu-Ping , Tong Xun-Liang , Huang Qiang-Ru , Jia Meng-Meng , Yang Wei-Zhong , Feng Lu-Zhao 
Published: August 2023

Abstract
Background
Respiratory syncytial virus (RSV) infection in infants is a global health priority. We aimed to investigate the common manifestations of RSV infection by age group and human development index (HDI) level and to assess its association with the development of wheezing and recurrent wheezing illness.

Methods
We searched the literature published between January 1, 2010 and June 2, 2022 in seven databases. Outcomes included common manifestations and long-term respiratory outcomes of RSV infection in children. Random- and fixed-effect models were used to estimate the effect size and their 95% confidence intervals. Subgroup analysis was conducted by age and HDI levels. This review was registered in PROSPERO (CRD42022379401).

Results
The meta-analysis included 47 studies. The top five manifestations were cough (92%), nasal congestion (58%), rhinorrhea (53%), shortness of breath (50%), and dyspnea (47%). The clinical symptoms were most severe in infants. In our analysis, compared to very high and high HDI countries, fewer studies in medium HDI countries reported related manifestations, and no study in low HDI countries reported that. The RSV-infected infants were more likely to develop wheezing than the non-infected infants [odds ratio (OR), 3.12; 95% CI, 2.59–3.76] and had a higher risk of developing wheezing illnesses after recovery (OR, 2.60; 95% CI, 2.51–2.70).

Conclusions
Cough and shortness of breath are common manifestations of RSV infection. More attention should be given to infants and areas with low HDI levels. The current findings confirm an association between RSV infection and wheezing or recurrent wheezing illness.
Impact of a recent wildfire on tortoises at Cape Point, South Africa, and implications for the interpretation of heated bones in the archaeological record
Authors: Stahlschmidt M. C. , Mentzer S. M. , Heinrich S. , Cooper A. , Grote M. N. , McNeill P. J. , Wilder J. C.-B. , Steele T. E. 
Published: August 2023

AbstractHeat-altered bones are a common occurrence in the archaeological record, and their analysis can provide detailed insights into past fire use behaviors and subsistence strategies. Heat-altered bones, however, may also result from natural fire events such as wildfires that are unrelated to human activity. We currently lack robust reference materials from natural fire events, analyzed using the same methodological approaches as we apply them to archaeological assemblages, that can be used to differentiate between natural and anthropogenic origins of heated materials. Here, we studied an assemblage of 50 tortoises that perished in a brushfire in Cape Point, South Africa. We used a combination of (1) zooarchaeological assessments of heating pattern and (2) infrared spectroscopy including a heating experiment to reconstruct heating temperatures with the aim to document the fire impact on the tortoise remains. For both approaches, we used statistical models to develop and test predictions that can also be applied to archaeological material. Our analyses suggest a quickly moving and low temperature brushfire in the study region with a generally low and superficial heating impact on the tortoise remains. However, we also observed several high-temperature alterations with calcination and speculate that naturally occurring fuel sources controlled the severity of the fire impact. The evidence of heating on the tortoise was unpatterned. We conclude that temperature alone presents a low confidence deciding factor between wildfires and campfires while skeletal heating pattern, in concert with other contextual analysis, may be able to facilitate this distinction with more localized heating signatures for campfires.
Analytical solutions of linear delay-differential equations with Dirac delta function inputs using the Laplace transform
Authors: Sherman Michelle , Kerr Gilbert , González-Parra Gilberto 
Published: August 2023

AbstractIn this paper, we propose a methodology for computing the analytic solutions of linear retarded delay-differential equations and neutral delay-differential equations that include Dirac delta function inputs. In numerous applications, the delta function serves as a convenient and effective surrogate for modeling high voltages, sudden shocks, large forces, impulse vaccinations, etc., applied over a short period of time. The solutions are obtained using the Laplace transform method, in conjunction with the Cauchy residue theorem. The accuracy of these solutions are assessed by comparing them with the ones provided by the method of steps. Numerical examples illustrating the methodology are presented and discussed. These examples show that the Laplace transform solution is very reliable for linear retarded delay-differential equations, because the analytic solution, for a single delta function input, is continuous. However, for linear neutral delay-differential equations with a delta function input the analytic solution is discontinuous. Consequently, the well-known Gibbs phenomenon is observed in the vicinity of the discontinuities. However, for neutral delay differential equations, we show that in some cases, the magnitude of the jumps at the discontinuities decrease, as time increases. Therefore, the Gibbs phenomenon of the Laplace solution dissipates.