bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and genotype distribution of human papillomavirus among women with cervical or vaginal lesions in Jiangsu, China: 2 cross-sectional studies (2012–2013 and 2020–2021)
Authors: Han Weiwei , Wang Wenjuan , Chu Kai , Bi Zhaofeng , Chen Qi , Li Jingxin , Zhu Fengcai 
Published: January 2025

Abstract

Background
Human papillomavirus (HPV) infection is a major risk factor of cervical cancer. This study assessed the prevalence and distribution of HPV genotypes in women with cervical or vaginal lesions in Jiangsu Province, China.

Methods
A total of 2120 healthy women aged 18–45 years were screened between 2012 and 2013 and 6171 healthy women aged 18–45 years were screened between 2020 and 2021 in Jiangsu Province. Cervical specimens collected from each woman were first tested using the HPV DNA enzyme immunoassay method, and positive samples were further tested using the reverse hybridization line probe assay. Differences in HPV prevalence and genotype distribution were compared between women with cervical and vaginal lesions identified during 2 rounds of cross-sectional screening. To account for differences in age composition between the 2 studies, the standardized prevalence of HPV positivity was calculated using the sum of the total number of women diagnosed with cervical or vaginal lesions during both periods as the standard group.

Results
Overall, 40 women (1.89%) were diagnosed with cervical or vaginal lesions through biopsy during 2012–2013, and 110 (1.78%) were diagnosed during 2020–2021. Among women with lesions, the standardized HPV positivity rates were 98.41% in 2012–2013 and 99.24% in 2020–2021. Most cases were caused by high-risk HPV, which accounted for 87.18% of the total infections during 2012–2013 and 89.91% of those in 2020–2021, with standardized positivity rates of 86.44% and 88.75%, respectively. The standardized positivity rates for single infections were 62.35% in 2012–2013 and 74.95% in 2020–2021. The top 5 high-risk HPV genotypes were HPV type 16 (HPV16; 29.01%), 52 (20.63%), 18 (14.28%), 58 (13.71%), and 33 (12.12%) in 2012–2013, and HPV16 (36.95%), 58 (22.18%), 52 (13.25%), 31 (7.63%), and 51 (6.81%) in 2020–2021. The standardized positivity rate for HPV18 decreased from 14.28% in 2012–2013 to 1.15% in 2020–2021. Among women with cervical or vaginal lesions, the highest proportion was observed in the 36- to 45-year group during 2012–2013, reaching 52.50%, and in the 26- to 35-year group during 2020–2021, peaking at 59.10%.

Conclusions
In Jiangsu Province, no significant changes in HPV prevalence among women with cervical or vaginal lesions were observed during 2012–2013 and 2020–2021; however, the distribution of HPV genotypes had changed.
Platelet-Rich Plasma Versus Corticosteroids in the Treatment of Plantar Fasciitis: A Systematic Review and Meta-Analysis
Authors: Zuo Ankai , Gao Chengfei , Jia Qiufeng , Zhang Meirong , Fu Ting , Li Tieshan , Wang Lin 
Published: January 2025

Abstract

Objective
This study aims to compare the efficacy of platelet-rich plasma (PRP) and corticosteroids (CS) in treating plantar fasciitis, focusing on pain relief, foot function, and plantar fascia thickness to identify the optimal treatment approach.

Design
A comprehensive search of medical databases was conducted following PRISMA guidelines, utilizing an extensive keyword strategy. Inclusion criteria encompassed prospective RCTs involving adult patients with plantar fasciitis treated with local PRP or CS injections, specifically assessing outcomes such as the Visual Analogue Scale (VAS), American Orthopaedic Foot and Ankle Society (AOFAS) scores, and plantar fascia thickness.

Results
The meta-analysis included 24 RCTs with 1653 participants. PRP injections yielded significantly better VAS scores compared to CS injections at 3 months (P = 0.03) and 6 months (P < 0.001), with no significant differences at 1 month (P = 0.12) and 12 months (P = 0.08). AOFAS scores demonstrated that PRP was superior to CS at 3 (P = 0.05), 6 (P < 0.001), and 12 months (P < 0.001), with no significant differences at 1 month (P = 0.31). Regarding plantar fascia thickness, there were no significant differences between PRP and CS at 1-1.5 months (P = 0.18), 3 months (P = 0.64), and 6 months (P = 0.05).

Conclusions
PRP injections offer superior pain control compared to corticosteroids in the medium term (3-6 months) but not in the short term or at one year.
Effectiveness of amnion allograph injections in patients with degenerative musculoskeletal diseases: a systematic review and meta-analysis
Authors: Hou Wen-Hsuan , Lin Pi-Chu , Tung Kuang-Mou , Chen Su-Ru 
Published: January 2025

Abstract

Objective
Amnion allograft injections have emerged as potential regenerative therapy for degenerative musculoskeletal diseases. In this study, we conducted a systematic review and meta-analysis to evaluate the effectiveness of amnion allograph injections in patients with degenerative musculoskeletal diseases.

Design
A search was conducted across the PubMed, Embase, Cochrane, and Web of Science databases to identify studies reporting on amnion allograft injections in patients with degenerative musculoskeletal diseases. The outcomes assessed were pain reduction at different time points, physical functional improvements, and quality of life (QoL).

Results
In total, seven studies were included. The quality assessment indicated that only three studies had a low overall risk of bias. Pooled effect sizes indicated significant improvements in overall pain of -0.959 (95% confidence interval (CI): -1.483 ~ -0.435, p < 0.001), pain at 2–4 weeks of -2.609 (95% CI: -3.334 ~ -1.884, p < 0.001), at 3–6 months of 0.834 (95% CI: -1.077 ~ -0.590, p < 0.001), and at 1–2 years of -0.518 (95% CI: -1.025 ~ -0.011, p = 0.045), physical function of 0.679 (95% CI: 0.202 ~ 1.156, p = 0.005), and QoL of 1.407 (95% CI: 0.273 ~ 2.541, p = 0.015). No significant covariant was identified by subgroup analyses.

Conclusions
Results indicated that amnion allograft injections produced significant pain reduction, functional improvement, and QoL enhancement in patients receiving injections compared to control groups, particularly in terms of pain reduction.
A Quality Improvement Initiative to Reduce Surgical Site Infections in Pediatric Patients Undergoing Cardiothoracic Surgery
Authors: Golden Cassidy , Murphy Kathy , Rosenblum Joshua M. , Eriksson Charlotta , Dunaway Parker , Lukacs Mary , Newberry Lisa , Gleason Michelle E. , Calamaro Christina J. , Basu Mohua , Chanani Nikhil K. , Shashidharan Subhadra , Fundora Michael P. 
Published: January 2025

Introduction:
This project aimed to decrease surgical site wound infections (SSIs) to less than 1 per 100 cases in pediatric patients after cardiothoracic surgery.

Methods:
A multidisciplinary workgroup was established to identify perioperative risk factors, and educational gaps and create a bedside quality improvement (QI) rounding group to monitor wounds. SSIs were defined according to the Centers for Disease Control National Healthcare Safety Network guidelines. Infection preventionists adjudicated infections as SSIs after an SSI huddle evaluated the case. A QI bundle was developed more than 2 eras: 2015 criteria included an enhanced hygiene bundle, scripted discharge telephone calls about wound care, and 2019 criteria identified SSI risk factors, developed an SSI-QI rounding team, created additional wound care education, and standardized wound care. Data were collected from January 2014 to December 2022 to assess SSI rates per 100 surgical cases, as well as clinically relevant short- and long-term outcomes.

Results:
From December 2014 to December 2022, there were 5,610 surgical cases evaluated in SSI-QI rounds. Compared with the preintervention cohort, SSI rates decreased significantly during the intervention (SSI per 100 cases 2.82; 95% confidence interval, 1.94–4.09) and postintervention (SSI per 100 cases 0.55; 95% confidence interval, 0.24–1.26). There were no increases in reoperations, postoperative major complications, or discharge mortality throughout the study.

Conclusions:
SSI rates decreased below the goal of 1 per 100 surgical cases. Standardized wound dressings, improving hygiene compliance including bath compliance from 80% to 96.1%, multidisciplinary collaboration, bedside rounds, and postdischarge procedures contributed to lowering and sustaining low SSI rates.
A Standardized Approach to Transition Improves Care of Young Adults with Inflammatory Bowel Disease
Authors: Katz Daphna , Lee Stephanie , Sathananthan Vidiya , Bayes Santos Liz , Langshaw Amber 
Published: January 2025

Introduction:
Young adults with inflammatory bowel disease (IBD) are at the risk of poor outcomes when transferring to adult providers. We aimed to increase the percentage of patients with 14–17 years of age undergoing the transition of care and the percentage of patients 18–21 years of age initiating the transfer of care to 50% for 12 months. Our goal was also to improve patient satisfaction with the transfer process. Our balancing measure was not to increase the duration of IBD visits.

Methods:
We implemented 3 interventions through iterative plan-do-study-act cycles. To understand the impact of the interventions for 12 months, we used statistical process control charts. The duration of IBD visits was used as a balancing measure. We administered an anonymous satisfaction survey through the electronic health record.

Results:
Total transition discussions increased to a mean of 38% (n = 68). Transition discussions with patients 14–17 years of age increased from baseline, though not consistently. Patients 18–21 years of age initiating transfer of care increased to a mean of 5% (n = 1) following the first intervention and to a mean of 30% (n = 13) following our second and third interventions with special cause variation. There was no significant difference in the duration of IBD visits before and after the intervention period (P = 0.54). No patients were dissatisfied following our interventions.

Conclusions:
We saw improved transition discussions and transfer initiation rates by implementing the first steps of a new process to transition young adults with IBD.
Challenges of continuous cropping obstacles in Panax ginseng: Formation and response mechanisms
Authors: Chen Kang , Tong Yuru , Wang Tielin , Zhou Xiuteng , Zhou Junhui , Ge Yang , Zheng Han , Yu Muyao , Luo Yunfeng , Ji Ruifeng 
Published: January 2025

Abstract

Panax ginseng, a perennial herbaceous plant and a representative of the Panax genus, is renowned for its exceptional medicinal value and economic benefits, often referred to as the “King of Herbs.” With the increasing market demand and the limited availability of suitable cultivation land, the issue of continuous cropping obstacles for P. ginseng has become increasingly prominent, directly hindering the sustainable development of the ginseng industry. This article summarizes the concept and hazards of continuous cropping obstacles and, drawing on the latest research, provides an in-depth analysis of the causes and response mechanisms. This work aims to establish a solid foundation for future research into the mechanisms of continuous cropping obstacles in P. ginseng.
Comparison of WHO laboratory-based and non-laboratory-based CVD risk Charts among Hypertensive Adults Attending Primary Healthcare Centers in West Africa Sub-region
Authors: Hutton-Mensah Kojo Awotwi , Ibrahim Olayinka Rasheed , Nwankwo Adaku M , Nketia George Bediako , Adeniyi Funmi Temidayo , Natogmah Abukari Yakubu , Ogunmodede James Ayodele , Ojji Dike , Adesola Olumide , Alabi Biodun Sulyman , Mokuolu Olugbenga Ayodeji , Sarpong Daniel 
Published: January 2025

AbstractBackgroundThe World Health Organization (WHO) non-laboratory cardiovascular disease (CVD) risk chart is sub-region-specific and is advocated in resource-constrained settings. However, the extent of agreement with laboratory-based assessment among hypertensive adults attending primary health centers (PHCs) in the West Africa sub-region remains unknown. This study compared 10-year CVD risk among adults with hypertension attending PHCs in Ghana and Nigeria.Materials and MethodsThis cross-sectional study recruited 319 adults with hypertension at PHCs in Ghana and Nigeria. All participants had their blood pressures, anthropometrics, fasting blood sugar, and fasting cholesterol measured following standard procedures. WHO laboratory and non-laboratory CVD risks were assessed and compared using Kappa’s statistics, correlation, and Bland-Altman Plot.ResultsThe median (interquartile range) for laboratory-based and non-laboratory-based CVD risk scores were comparable [7.0 (4.0 11.0) vs. 7.0 (4.0 to 11.0), p = 0.914]. Of the 319 participants, laboratory-based assessment classified 214 (67.1%) as low risk, while 210 (65.8%) were classified as low risk using the non-laboratory method. Eleven (3.4%) and 14 (4.4%) participants were classified as high-risk using laboratory- and non-laboratory-based methods, respectively. Overall, there was a very good positive correlation between the CVD risk assessment methods (r = 0.948, p<0.001). For all participants combined, there was substantial agreement (Kappa statistics), with K = 0.766. Bland-Altman showed a mean bias of 0.15 (SD = 1.74) in favor of non-laboratory-based assessment of CVD with an upper limit of 3.57 and a lower limit of -3.26.ConclusionThere was substantial agreement between laboratory- and non-laboratory-based WHO CVD risk charts in this study. In low-resource settings, such as Ghana and Nigeria, the WHO non-laboratory CVD risk prediction model offers a huge opportunity for primary CVD prevention in adults with hypertension.
Development and Implementation of a Minority Health International Infectious Diseases Research Training Program
Authors: Sy Angela , Taylor Diane , Leaungwutiwong Pornsawan , Phanupak Nittaya , Sirida Youngchim , Leke Rose , Humphrey Peter S. , Tandon Ravi , Kulkarni Madhur , Madhivanan Purnima , Kaholokula Joseph Keawe‵aimoku , Nerurkar Vivek R. 
Published: January 2025

AbstractFrom 2014-2019, the University of Hawai‵i (UH) at Manoa offered a National Institutes of Health funded Minority Health International Research Training (MHIRT) Program for undergraduate research experiences in infectious diseases. The goal of the program was to immerse undergraduate students in conducting global infectious diseases research to train a new generation of scientists to combat future global pandemics. The MHIRT program trained educationally underrepresented groups unique in Hawai‵i: Native Hawai‵ians and other Pacific Islanders, and underrepresented Asian Americans, e.g., Filipinos and Vietnamese. A 12-member Advisory Committee guided the program development, implementation, recruitment strategies, recruitment, retention, and program evaluation. The program provided an eight-month classroom and field based international research training. Students learned about “8 steps of research” and cultural competency, experienced a hands-on research project abroad, and presented their results to the research community in the host country and at UH. Students’ research topics focused on ongoing projects of UH faculty including those with international collaborations in infectious disease and tropical medicine. Students spent two months on an international research mentor’s project at an international site under the mentorship of a Hawai‵i based research faculty. After eight months, students graduated from the program by presenting their research to family, friends, mentors, and UH faculty and administrators. Trainees in this program pursued academic graduate or professional health degrees. The majority of students pursued further studies related to infectious diseases contributing to workforce development in infectious disease health research. The UH-MHIRT program provides an example of student immersion in international infectious disease research to foster future interest in global health research providing potential benefits for the student and faculty and their research efforts.
Assessing Knowledge, Uptake and Factors associated with cervical cancer screening among women in selected communities of Wakiso District in Uganda: A population-based study
Authors: Bulamba Robert. M. , Kyasanku Emmanuel , Nalugoda Fred , Daama Alex , Nkale James Menya , Miller Amanda P. , Byansi William , Namutundu Juliana , Kigozi Godfrey , Nalwoga Grace K. , Balwanaki Chris , Watya Stephen , Ekström Anna Mia , Mugamba Steven , Ndejjo Rawlance , Nakigozi Gertrude 
Published: January 2025

BackgroundUganda has the highest prevalence and incidence of cervical cancer in the East African region, with 80% of women diagnosed at advanced stage when survival is minimal. Literature on uptake of cervical cancer screening is limited in Uganda and thus womens’ knowledge and uptake of cervical cancer screening in the general population remains unknown. This study examined this gap of knowledge among women aged 25-65 years, across rural, urban and semi urban communities in a Ugandan district to inform design of targeted future cervical cancer screening programs in the country.MethodsThis descriptive cross-sectional study was conducted in Wakiso district, Uganda in May 2024 among 783 eligible women. Face-to-face interviews were conducted. Uptake of cervical cancer screening (outcome of interest)) was dichotomously (yes/no) assessed. Knowledge of cervical cancer disease was assessed using the AWACAN validated tool, knowledge of cervical cancer screening was assessed using a set of ten (10) questions adapted from previous studies elsewhere, and all were measured on a Likert scale. Univariate, bivariate, and multivariable Poisson regression models with robust variance were performed using Stata software version 17.ResultsRespondents’ median age was 31 years (IQR 27-39 years). Majority (89.5%, 701/783) had heard of cervical cancer, and 90.6% (635/701) were aware of screening. Median knowledge score on signs and symptoms, risk factors and cervical cancer screening was 8.0 (IQR= 5-10), 8.0 (IQR= 5-11) and 7.0 (IQR= 4-10) respectively, and 54.3% had high knowledge about cervical cancer screening. Uptake of cervical cancer screening was 33.4%. Living in urban areas (aPR = 1.41, 95% CI: 1.05 – 1.88), being the ages 40-49 years (aPR = 1.76, 95% CI: 1.36 – 2.27), 50 years and above (APR = 2.16, 95% CI: 1.53 – 3.04), smoking (aPR = 1.39, 95% CI: 1.05 – 1.86), partner involvement (aPR = 2.61, 95% CI: 2.12–3.21), high knowledge about cervical cancer screening (aPR = 3.29, 95% CI: 2.35–4.60), and living with HIV (aPR = 1.66, 95% CI: 1.66–2.13) were significantly associated with higher uptake of cervical cancer screening among women in this setting.ConclusionKnowledge of cervical cancer screening was high, but the uptake of cervical cancer screening was lower than the recommended population coverage by WHO and Uganda national guidelines. There is need to improve accessibility to cervical cancer screening, increase nationwide cervical cancer awareness campaigns focusing on high-risk age groups and design targeted, tailored, culturally and socially sensitive interventions for young women aged 25-39 years to improve cervical cancer screening in Uganda.
AIRWAY-XR: Augmented Instruction to Refine Wayfinding and Yielding Skills in Emergency Medicine Residents for Intubation using Mixed Reality Technology
Authors: Bhavsar Neil , Sriram Sandhya , Balasubramanian Shriman , Davidson Christian , Piechowski Wojciech , Zimm Jordan , Sanapala Sowmya , Fortenko Alexander , Lame Maria , Greenwald Peter Wagoner , St. George Jonathan , Sigaras Alexandros 
Published: January 2025

AbstractThe goal of this study was to assess if mixed reality technology (MR) is a feasible training tool for educating new learners in endotracheal intubation. This is a feasibility trial to establish the feasibility of an MR airway education module compared to traditional airway teaching. The study participants were twenty-one postgraduate year one (PGY1) physicians accepted to an emergency medicine residency program located in a large, urban setting. The residency program is located in New York City, and has academic affiliations with two large, urban, academic emergency departments (ED) that each treat over seventy thousand patients per year. We enrolled 20 Emergency Medicine (EM) first-year residents into two research arms. Group A consisted of 10 first-year residents who utilized a novel MR education module containing self-guided training and real-time feedback via the Microsoft HoloLens 2. Group B consisted of 10 first year residents who trained on a phone-based module containing the same self-guided content and received real-time training via iPad, which is the traditional didactic format. Both groups had remote Senior EM Residents (PGY3) coaches who provided feedback and direction to the participants. Groups were subsequently assessed by Attending EM Physicians on a 10-point scale and given a post-survey to provide feedback on their experience. There was no difference in scores between the HoloLens 2 users and iPad users (HoloLens score [8.6] v. iPad score [8.5]; p = 0.56) or in completion time between the two groups (HoloLens = [3.4 +/− 0.9 min] v. iPad = [3.3 +/− 1.4 min]; p = 0.45). Out of the Group A participants, 70% rated their overall experience between good and excellent. We concluded that using the HoloLens 2 as a didactic model for intubation is feasible, with possible evidence for noninferiority to traditional didactic models if explored further in a larger standardized trial.
‘It’s only a flesh wound’ – understanding the safety culture in equine, production animal and mixed veterinary practices
Authors: Tulloch John S.P. , Schofield Imogen , Jackson Rebecca , Whiting Martin 
Published: January 2025

AbstractThe veterinary industry has some of the highest rates of non-fatal work-related injuries, yet safety culture remains unexplored. Utilising a survey, this study aimed to describe the prevalence of work-related injuries in equine, production animal, and mixed veterinary practices, and to understand the behaviours of injured persons.There were 144 respondents. Over 90% of clinicians experienced injury during their careers, versus a third of non-clinical staff. Injuries to equine veterinarians were predominately kicks to the leg or head, and usually involved the examination of a horse’s distal limb, most were not wearing hard hats. Production animal veterinarians’ injuries included crushed hands and feet, and kicks to legs. Injuries often lead to hospital attendance (>25% equine, >40% production animal), yet few took time off work.Veterinarians avoided taking time off work after injuries, reasons included; minimisation of injury severity, not wanting to ‘let the team down’, and feelings of guilt. Many planned behaviour change post-injury, including using protective headwear, increasing awareness of surroundings, and using better restraint. Most injuries went unreported due to lack of awareness, acceptance of injury risk, time constraints, and believing reporting would have no impact.This study exposes a culture in large animal veterinary workplaces that normalises injuries and undervalues safety. The lack of protective measures and the tendency to continue working despite serious injuries, highlight a need for urgent cultural and systemic change. Improved safety practices, leadership commitment, and comprehensive training are essential to address this deep-seated issue and fostering a safer work environment.