bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergency Treatment of Soft Tissue and Dentoalveolar Fractures using Risdon Wiring in Children due to Motorcycle Accident : Case Report
Authors: Sjamsudin Endang , Yazid Y Harmas , Tasman Abel , Priyanto Winarno 
Published: February 2023

Introduction: Dentoalveolar fractures are often found in children due to physical trauma, falls, and motorized accidents. In pediatric patients, there are variations in age, jaw development, and dentition which are the primary considerations in choosing a dentoalveolar fracture treatment method. This case report aims to describe and discuss the emergency management of soft tissue injuries and mandibular dentoalveolar fractures with Risdon wiring in pediatric patients due to motorized accidents.
Case report: A 9-year-old female patient complained of bleeding from the mouth due to a traffic accident. Clinical and radiographic examination showed dentoalveolar segment fractures in tooth region 32-42, stab wounds, and lacerations on the inferior lip, vestibule, and gingiva in tooth region 32-42. The patient underwent wound cleaning, wound suturing, and treatment of dentoalveolar fractures with fixation using Risdon wiring in the mandibular region 36-46.
Conclusion: Conservative treatment of dentoalveolar fractures in pediatric patients with minimal intervention can give good results. Risdon wiring as a fixation method can be used in the emergency treatment of dentoalveolar fractures in pediatric patients with mixed dentition.
Keywords: Soft tissue trauma, dentoalveolar fracture, Risdon wiring, emergency
Recensioni
Authors: Tosi Silvia , Bloom Dan , Melnick Joseph 
Published: February 2023

- Dreitzel P. (2018). The Art of Living and the Joy of Life. Development and Maturity in a Changing World. Siracusa: Istituto di Gestalt HCCItaly Publ. Co. (www.gestaltitaly.com). ISBN: 978-88-989-1207-0, pp. 339, € 39,00- Kato J., Klaren G., Levi N. (Eds.) (2019). Supporting Human Dignity in a Collapsing Field: Gestalt Approach in the Social and Political Contexts. Siracusa: Istituto di Gestalt HCC Italy Publ. Co. (www.gestaltitaly.com). ISBN: 978-88-989-1223-0, pp. 243, € 40,00
Цифровий інструментарій кадрової складової системи економічної безпеки підприємства
Authors: Ніжегородцев В. О. , Петренко Л. М. 
Published: February 2023

Кадрова безпека є однією зі складових економічної безпеки підприємства разом з іншими, такими як: фінансова, силова, інформаційна, технологічна, правова, екологічна. Об’єктом кадрової безпеки підприємства варто вважати негативні внутрішні ризики підприємства та загрози, пов’язані з діяльністю персоналу, а також зовнішні фактори, що знижують рівень кадрової безпеки. Сьогодні доцільно приділити увагу питанню управління безпекою персоналу як комплексу організаційних та технічних заходів, що знижують загрози безпеці персоналу на підприємствах. Серед існуючих засобів забезпечення безпеки підприємства можна виокремити інформаційні засоби. Корисними для поліпшення засад кадрової складової системи економічної безпеки підприємства, на нашу думку, можуть стати програмні інструменти з підтримки прийняття рішень. Серед програмного забезпечення підтримки прийняття рішень досить популярними є засоби аналізу рішень (Decision Analysis) та методи і програмне забезпечення «видобування даних» (Data Mining) – способу аналізу інформації у базі даних з метою відшукання аномалій і трендів без з’ясування значеннєвого змісту записів. На сьогодні вже доступні деякі основні державні електронні сервіси через мережу «Інтернет» за допомогою пошуку даних з різноманітних реєстрів, де можна отримати уніфіковані дані кадрової складової системи економічної безпеки підприємства. Запропоновані складові цифрового інструментарію щодо побудови ефективної системи економічної безпеки підприємства дозволять досягти найбільш високого рівня економічної безпеки.
Актуалізація і динаміка розвитку деглобалізаційних процесів та їх впливу на формування економічної політики
Authors: Онишко С. , Бєлін В. 
Published: February 2023

Стаття присвячення дослідженню актуальної тенденції посилення деглобалізаційних процесів та зміни інтересів держави у сфері економічної політики. Потрясіння в торгово-економічному секторі внаслідок пандемії COVID-19 суттєво вплинули на експортно-імпортні відносини між окремими країнами. Аналізуючи динаміку зростання обмежувальних торгових заходів між країнами, з’ясовано, що наслідки світового карантину поступово призводять до зростання ролі деглобалізації, а саме регіональної інтеграції та глокації. Визначено вплив воєнних дій в Україні на розвиток деглобалізаційних процесів. Зроблено висновок про важливість аналізу й відображення об’єктивного впливу деглобалізаційних процесів з позицій взаємозв’язку з формуванням економічної політики.
Математична модель опису фону автомобільних транспортних засобів, що функціонують у контрольованій зоні біля стратегічного об’єкта
Authors: Azarenko Olena , Honcharenko Yulia , Divizinyuk Mykhailo , Mirnenko Volodymyr , Lukashenko Victoria 
Published: February 2023

Мета роботи: розробка математичної моделі опису фону автомобільних транспортних засобів, що функціонують у контрольованій зоні біля стратегічного об’єкта.
Метод дослідження: дослідження здійснювалися з використанням методів систем масового обслуговування та функціональ-ного аналізу, системного аналізу та математичного моделювання, теорії систем та теорії автоматизованого управління.
Результати дослідження: математична модель опису фону автомобільних транспортних засобів, що функціонують у контрольованій зоні біля стратегічного об’єкта.
Теоретична цінність дослідження: уточнено визначення ситуаційного фону автомобільних транспортних засобів та класифікацію порушень використання автомобільних транспортних засобів; розроблено математичну модель, яка описує ситуаційний фон автомобільних транспортних засобів.
Тип статті: функціонально-синтезуючий, що описує нову модель динамічного процесу.
Portable paper-based electrochemiluminescence test incorporating lateral-flow immunosensors for detection of interferon-γ levels
Authors: Yuan Shichao , Xie Guihua , Yang Xiang , Chen Yu , Zhang Hongbin 
Published: February 2023

Tuberculosis (TB) poses a serious threat to human health and social development. Accurate diagnosis of mycobacterium tuberculosis infection plays a critical role in the prevention and treatment of tuberculosis. Interferon-γ (INF-γ) release assay (IGRA) is currently the only quantitative tuberculosis infection diagnosis method. An accurate, fast, and easily handled INF-γ detection method is the key to obtaining accurate results. Herein, we report a novel paper-based electrochemiluminescence (ECL) method based on lateral flow immunosensors that combines the easy handling characteristics of immunochromatography and the high sensitivity of electrochemiluminescence to detect IFN-γ. To our knowledge this is the first INF-γ detection method that combines immunochromatography with electrochemiluminescence. The paper-based ECL-LFI test consists of a sample pad, conjugation pad (with binding antibody IFN-γ-Ab1 conjugated with ruthenium tripyridine), detection pad (with capture antibody IFN-γ-Ab2 immobilized on nanospheres), absorbent pad, and electrode for signal activation. The ECL signal is obtained by cyclic voltammetry scanning at a speed of 0.1 V/s in the detection area of the paper-based ECL-LFI test. In our experiments, the paper-based ECL-LFI test exhibited a minimum detection limit of 2.57 pg/mL within 12 min, and a broad detection range of 2.57–5,000 pg/mL, with repeatability of 8.10% and stability of 4.97%. With the advantage of high accuracy and sensitivity, easy handling, and low user training requirements, this ECL-LFI test might be used as point-of-care testing (POCT) in the IGRA for tuberculosis diagnosis.
SARS-CoV-2 infection of intestinal epithelia cells sensed by RIG-I and DHX-15 evokes innate immune response and immune cross-talk
Authors: Zhang Lijuan , Zhang Yize , Wang Ruiqin , Liu Xiaoning , Zhao Jinmeng , Tsuda Masato , Li You 
Published: February 2023

SARS-CoV-2 causes a spectrum of clinical symptoms from respiratory damage to gastrointestinal disorders. Intestinal infection of SARS-CoV-2 triggers immune response. However, the cellular mechanism that how SARS-CoV-2 initiates and induces intestinal immunity is not understood. Here, we exploited SARS-CoV-2-GFP/ΔN trVLP pseudo-virus system and demonstrated that RIG-I and DHX15 are required for sensing SARS-CoV-2 and inducing cellular immune response through MAVS signaling in intestinal epithelial cells (IECs) upon SARS-CoV-2 infection. NLRP6 also engages in the regulation of SARS-CoV-2 immunity by producing IL-18. Furthermore, primary cellular immune response provoked by SARS-CoV-2 in IECs further cascades activation of MAIT cells and produces cytotoxic cytokines including IFN-γ, granzyme B via an IL-18 dependent mechanism. These findings taken together unveil molecular basis of immune recognition in IECs in response to SARS-CoV-2, and provide insights that intestinal immune cross-talk with other immune cells triggers amplified immunity and probably contributes to immunopathogenesis of COVID-19.
Mucor indicus caused disseminated infection diagnosed by metagenomic next-generation sequencing in an acute myeloid leukemia patient: A case report
Authors: Shen Meixiao , Li Qian , Zeng Zhaocheng , Han Dongxu , Luo Xiansheng 
Published: February 2023

BackgroundMucormycosis commonly occurs in immunosuppressed patients with hematological diseases, which can be life-threatening. However, many cases are often misdiagnosed due to lack of specific clinical manifestations. Additionally, the traditional blood culture or serological testing, with a high false-negative rate, is time-consuming. Thus, precise and timely diagnosis of infections is essential for the clinical care of infected patients.Case presentationWe report a 29-year-old Chinese man with acute myeloid leukemia (AML) who developed febrile neutropenia after the first course of induction chemotherapy. He received empirical antibiotics, which did not relieve his symptoms. No pathogen was detected by traditional microbiologic assays, while Mucor indicus was identified by metagenomic next-generation sequencing (mNGS) in the blood specimen. Liposomal amphotericin B (LAmB) was used, resulting in the patient’s temperature returning to normal. A few days later, abdominal computed tomography (CT) scan showed multiple liver abscesses; fluorescence staining, histopathology, and mNGS identified the causative agent—M. indicus. Posaconazole was combined with LAmB as long-term antifungal treatment. Finally, the patient received allogeneic hematopoietic stem cell transplantation successfully after controlled infection. During follow-up 1 year after transplantation, the number of liver abscesses was reduced to one and remained stable.ConclusionThis report described the first case of an AML patient diagnosed with culture-negative disseminated infections caused by M. indicus leading to rare hepatic manifestations using mNGS of peripheral blood and liver biopsy. LAmB combined with posaconazole was given in time, resulting in a favorable outcome. mNGS is a new method that assists in detecting the probable pathogen and increases the accuracy of identifying an etiology.
Additional improvement in regional myocardial ischemia after intracardiac injection of bone marrow cells during CABG surgery
Authors: Gowdak Luís Henrique Wolff , Schettert Isolmar Tadeu , Rochitte Carlos Eduardo , de Carvalho Leonardo P. , Vieira Marcelo Luiz Campos , Dallan Luís Alberto Oliveira , de Oliveira Sérgio Almeida , César Luiz Antonio Machado , Brito José Oscar Reis , Guarita-Souza Luiz César , de Carvalho Antonio Carlos Campos , Krieger Jose Eduardo 
Published: February 2023

BackgroundPost-procedure residual ischemia is associated with worse prognosis in patients with coronary artery diasease (CAD).ObjectiveWe evaluated whether autologous bone marrow-derived cells (BMC) contribute to additional reduction in regional stress-induced myocardial ischemia (SIMI) in patients undergoing incomplete coronary artery bypass graft surgery (CABG).MethodsIn a double-blind, randomized, placebo-controlled trial, we enrolled 143 patients (82% men, 58 ± 11 years) with stable CAD and not candidates for complete CABG. They received 100 million BMC (n = 77) or placebo (n = 66) injected into ischemic non-revascularized segments during CABG. The primary outcome was improvement on SIMI quantified as the area at risk in injected segments assessed by cardiovascular magnetic resonance (CMR) 1, 6, and 12 months after CABG.ResultsThe reduction in global SIMI after CABG was comparable (p = 0.491) in both groups indicating sustained beneficial effects of the surgical procedure over 12 month period. In contrast, we observed additional improvement in regional SIMI in BMC treated group (p = 0.047). Baseline regional SIMI values were comparable [18.5 (16.2–21.0) vs. 18.5 (16.5–20.7)] and reached the lowest values at 1 month [9.74 (8.25; 11.49) vs. 12.69 (10.84; 14.85)] for BMC and placebo groups, respectively. The ischemia’s improvement from baseline represented a 50% difference in regional SIMI in favor of the BMC transplanted group at 30 days. We found no differences in clinical and LVEF% between groups during the 12 month follow-up period. The 1 month rate of major adverse cerebral and cardiovascular events (MACCE) (p = 0.34) and all-cause mortality (p = 0.08) did not differ between groups 1 month post intervention.ConclusionWe provided evidence that BMC leads to additional reduction in regional SIMI in chronic ischemic patients when injected in segments not subjected to direct surgical revascularization. This adjuvant therapy deserves further assessment in patients with advanced CAD especially in those with microcirculation dysfunction.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT01727063
Is it time for class I recommendation for sodium-glucose cotransporter-2 inhibitors in heart failure with mildly reduced or preserved ejection fraction?: An updated systematic review and meta-analysis
Authors: Treewaree Sukrit , Kulthamrongsri Narathorn , Owattanapanich Weerapat , Krittayaphong Rungroj 
Published: February 2023

BackgroundIn heart failure with reduced ejection fraction (HFrEF), sodium-glucose cotransporter-2 (SGLT2) inhibitors were demonstrated to lower cardiovascular mortality (CV death) and hospitalization for heart failure (HHF); however, the advantages of SGLT2 inhibitors in heart failure with mildly reduced (HFmrEF) or preserved ejection fraction (HFpEF) are less clear. SGLT2 inhibitors were reported to enhance quality of life (QoL) in HFmrEF or HFpEF patients; however, the findings among studies are inconsistent.ObjectiveTo conduct an updated systematic review and meta-analysis of recent data to assess the effect of SGLT2 inhibitors on cardiovascular outcomes and QoL in patients with HFmrEF or HFpEF.MethodThree databases were searched for studies that evaluated SGLT2 inhibitors and their effect on cardiovascular outcomes, including CV death, HHF, all-cause death, and the composite outcome of CV death, HHF, and urgent visit for heart failure (HF), and patient QoL (Kansas City Cardiomyopathy Questionnaire [KCCQ] score compared to baseline, and increase in KCCQ score ≥ 5 points) that were published during January 2000–August 2022. The meta-analysis was performed using the inverse variance method and random-effects model. INPLASY registration: INPLASY202290023.ResultsSixteen studies (9 recent RCTs) were included, and a total of 16,710 HFmrEF or HFpEF patients were enrolled. SGLT2 inhibitors significantly reduced composite cardiovascular outcome (CV death/HHF/urgent visit for HF; pooled hazard ratio [HR]: 0.80, 95% confidence interval [95%CI]: 0.74–0.86) and HHF alone (HR: 0.74, 95%CI: 0.67–0.82), but there was no significant reduction in CV death alone (HR: 0.93, 95%CI: 0.82–1.05). Benefit of SGLT2 inhibitors for decreasing CV death/HHF was observed across all subgroups, including left ventricular ejection fraction (LVEF) range, diabetes status, New York Heart Association functional class, and baseline renal function. For total HHF, SGLT2 inhibitors conferred benefit in both LVEF 50–60% (HR: 0.64, 95%CI: 0.54–0.76), and LVEF &gt;60% (HR: 0.84, 95%CI: 0.71–0.98). Significant change was observed in the KCCQ-clinical summary score compared to baseline (mean difference: 1.33, 95%CI: 1.31–1.35), and meaningful improvement in QoL was shown across all 3 types of increase in KCCQ score ≥ 5 points.ConclusionThis study demonstrates the benefits of SGLT2 inhibitors for improving cardiovascular outcomes and QoL in HFmrEF or HFpEF patients.
Pulse-wave velocity assessments derived from a simple photoplethysmography device: Agreement with a referent device
Authors: Zieff Gabriel , Stone Keeron , Paterson Craig , Fryer Simon , Diana Jake , Blackwell Jade , Meyer Michelle L. , Stoner Lee 
Published: February 2023

ObjectivePulse-wave velocity (PWV), a common measure of arterial stiffness, can be measured continuously and across multiple body sites using photoplethysmography (PPG). The objective was to determine whether a simple photoplethysmography PPG PWV method agrees with a referent device.ApproachPhotoplethysmography heart-finger PWV (hfPWV) and heart-toe PWV (htPWV) were compared to oscillometric carotid-wrist PWV (cwPWV) and carotid-ankle PWV (caPWV) referent measurements, respectively. In 30 adults (24.6 ± 4.8 years, body mass index 25.2 ± 5.9 kg/m2, 18 female), three measurements were made: two supine baseline measurements (Base 1, Base 2) and one measurement (Tilt) 5 min after a modified head-up tilt test (mHUTT). Overall agreement and repeated measures agreement (change in PPG PWV from Base to Tilt vs. change in referent PWV from Base to Tilt) were calculated using linear mixed models. Agreement estimates were expressed as intra-class correlation coefficients (ICC).Main resultsFor hfPWV there was strong overall agreement (ICC: 0.77, 95%CI: 0.67–0.85), but negligible and non-significant repeated measures agreement (ICC: 0.10, 95%CI: −0.18 to 0.36). For htPWV, there was moderate overall agreement (ICC:0.50, 95%CI: 0.31–0.65) and strong repeated measures agreement (ICC: 0.81, 95%CI: 0.69–0.89).SignificancePhotoplethysmography can continuously measure PWV at multiple arterial segments with moderate-strong overall agreement. While further work with upper-limb PPG PWV is needed, PPG can adequately capture acute changes in lower-limb PWV.
Deep learning-based end-to-end automated stenosis classification and localization on catheter coronary angiography
Authors: Cong Chao , Kato Yoko , Vasconcellos Henrique Doria De , Ostovaneh Mohammad R. , Lima Joao A. C. , Ambale-Venkatesh Bharath 
Published: February 2023

BackgroundAutomatic coronary angiography (CAG) assessment may help in faster screening and diagnosis of stenosis in patients with atherosclerotic disease. We aimed to provide an end-to-end workflow that separates cases with normal or mild stenoses from those with higher stenosis severities to facilitate safety screening of a large volume of the CAG images.MethodsA deep learning-based end-to-end workflow was employed as follows: (1) Candidate frame selection from CAG videograms with Convolutional Neural Network (CNN) + Long Short Term Memory (LSTM) network, (2) Stenosis classification with Inception-v3 using 2 or 3 categories (&lt;25%, &gt;25%, and/or total occlusion) with and without redundancy training, and (3) Stenosis localization with two methods of class activation map (CAM) and anchor-based feature pyramid network (FPN). Overall 13,744 frames from 230 studies were used for the stenosis classification training and fourfold cross-validation for image-, artery-, and per-patient-level. For the stenosis localization training and fourfold cross-validation, 690 images with &gt; 25% stenosis were used.ResultsOur model achieved an accuracy of 0.85, sensitivity of 0.96, and AUC of 0.86 in per-patient level stenosis classification. Redundancy training was effective to improve classification performance. Stenosis position localization was adequate with better quantitative results in anchor-based FPN model, achieving global-sensitivity for left coronary artery (LCA) and right coronary artery (RCA) of 0.68 and 0.70.ConclusionWe demonstrated a fully automatic end-to-end deep learning-based workflow that eliminates the vessel extraction and segmentation step in coronary artery stenosis classification and localization on CAG images. This tool may be useful to facilitate safety screening in high-volume centers and in clinical trial settings.
Density structure beneath the Rungwe volcanic province and surroundings, East Africa from shear-wave velocity perturbations constrained inversion of gravity data
Authors: Njinju Emmanuel A. , Moorkamp Max , Stamps D. Sarah 
Published: February 2023

Density perturbations in the subsurface are the main driver of mantle convection and can contribute to lithospheric deformation. However, in many places the density structure in the subsurface is poorly constrained. Most geodynamic models rely on simplified equations of state or use linear seismic velocity perturbations to density conversions. In this study, we investigate the density structure beneath the Rungwe Volcanic Province (RVP), which is the southernmost volcanic center in the Western Branch of the East African Rift (EAR). We use shear-wave velocity perturbations (dlnvs) as a reference model to perform constrained inversions of satellite gravity data centered on the RVP. We use the code jif3D with a dlnvs-density coupling criterion based on mutual information to generate a 3D density model beneath the RVP up to a depth of 660 km. Our results reveal a conspicuous negative density anomaly (∼−200 kg/m3) in the sublithospheric mantle (at depths ranging from ∼100 km to ∼250 km) beneath the central part of the Malawi Rift extending to the west, beneath the Niassa Craton, coincident with locations with positive shear-wave velocity perturbations (+7%). We calculate a 3D model of the velocity-to-density conversion factor (f) and find negative f-values beneath the Niassa Craton which suggests the observed negative density anomaly is mostly due to compositional variations. Apart from the Niassa Craton, there are generally positive f-values in the study area, which suggest dominance of temperature control on the density structure. Although the RVP generally shows negative density anomalies and positive f-values, at shallow depths (&lt;120 km), f≈ 0, which suggests important contributions of both temperature and composition on the density structure possibly due to the presence of plume material. The negative buoyancy of the Niassa Craton contributes to its long stability, while constituting a barrier to the southward flow of plume material, thus restricting the southward continuation of magmatism in the Western Branch of the EAR. The presence of a negative-density anomaly where dlnvs are positive is incompatible with models based on the use of simple dlnvs to density conversion factors. These results have implications on how dlnvs models are converted to density perturbations.