bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of four automated clinical analyzers for the determination of total 25(OH)D in comparison to a certified LC-MS/MS
Authors: Favresse Julien , Fangazio Marco , Cotton Frédéric , Wolff Fleur 
Published: February 2023

Abstract

Objectives
The aim of this study was to compare the results of five methods for the determination of total 25(OH)D. For that purpose, two mass spectrometry and three immunoassay methods were used.

Methods
A total of 124 serum samples were analyzed on five different methods (i.e., a reference LC-MS/MS, Cascadion, Lumipulse, Roche Elecsys II and Roche Elecsys III). Analytical performance against LC-MS/MS was evaluated and compared to the Milan models 1 (analytical performance based on the clinical outcome using thresholds of 12, 20 and 30 ng/mL) and 2 (analytical performance based on biological variation). Additionally, imprecision studies and accuracy using NIST SRM972a samples were carried out.

Results
Compared to the reference LC-MS/MS method, the Lumipulse and the Roche Elecsys III assays reached the optimal criterion for bias, while the Cascadion met the desirable one. The Roche Elecsys II was not able to reach the minimal criteria. The proportion of correctly classified patients was higher using the Cascadion (95.2%) compared to the three immunoassays. In addition to its better precision, the Cascadion was not impacted by a high concentration of 3-epi-25(OH)D3 compared to the three immunoassays.

Conclusions
Compared to the LC-MS/MS reference method, the Cascadion presented the highest level of concordance at medical decision cut-offs for total 25(OH)D and reached the desirable specification for bias. Moreover, the presence of 3-epi-25(OH)D3 in enriched samples was only problematic in immunoassay methods, and especially considering Roche Elecsys methods. The release of performant fully automated mass spectrometry assays with high throughput might therefore facilitate the wide scale adoption of LC-MS/MS, even in non-specialized clinical laboratories.
Television Advertising in the 2022 Midterms
Authors: Franz Michael M. , Ridout Travis N. , Fowler Erika Franklin 
Published: February 2023

Abstract
This analysis focuses on broadcast advertising spending in congressional races in 2022. We discuss four patterns that characterized ads in these races. First, there was a record volume of television advertising for a midterm election. Despite frequent claims that traditional ads would begin to decline, the air war featured more spots than in 2014 and 2018. Second, Democrats continued to dominate ad totals, a trend that persisted from congressional elections in 2020 and 2018. Third, the agenda shifted to a discussion of abortion and inflation, two issues that were barely mentioned in political ads in prior cycles. Finally, outside groups remained a dominant force in many campaigns, but while their investments in prior cycles tended to be focused on Senate races, groups were also heavily involved in House races in 2022. Outside groups sponsored about 35% of all ads in House races, and they sponsored about 40% of ads in Senate races, both record highs. All told, television remains central to American elections. With each passing election, some aspects of the air war change, but the ubiquitous 30 s spot continues to be a go-to method of appealing to voters.
The stability and convergence analysis for singularly perturbed Sobolev problems with Robin type boundary condition
Authors: Duru Hakki , Gunes Baransel 
Published: February 2023

Abstract
This paper presents the robust and stable difference scheme to estimate singularly perturbed Sobolev boundary value problems with Robin type boundary condition.
Firstly, the asymptotic behavior of the solution is analyzed.
By using interpolating quadrature rules and basis functions, a completely exponentially fitted tree-level difference scheme is constructed on the uniform mesh.
Then an error estimation is investigated in a discrete energy norm.
Two numerical examples are solved and the computational results are tabulated.
Crystal structure of bis(dimethylammonium) poly[{μ4-1,1ʹ-(1,4-phenylenebis(methylene))bis(1H-pyrazole-3,5-dicarboxylato)-κ6
N
4
O
2}zinc(II)], C22H26N6O8Zn
Authors: Xia Yu-Pei , Huang Yu-Xin 
Published: February 2023

Abstract
C22H26N6O8Zn, monoclinic, P21/c (no. 14), a = 10.9820(8) Å, b = 10.5260(7) Å, c = 12.0980(11) Å, β = 118.661(2)°, V = 1227.13(17) Å3, Z = 2, R

gt
(F) = 0.0352, wR

ref
(F
2) = 0.1101, T = 298.15 K.
Behavior of Jointed Rock Specimens Reinforced with Bolts under Uniaxial Compression
Authors: Gong Zhicheng , Yang Wendong , Wang Ling , Fang Lindong , Li Weiteng , Li Yiwei 
Published: February 2023

Abstract
Discontinuously jointed rock mass is very common in rock engineering, and it has the characteristics of discontinuity, inhomogeneity, and anisotropy. Bolt has been an economic and effective technique to support underground rock mass, but the understanding of the bolt reinforcement mechanism to jointed rock mass remains limited. Uniaxial compression test of multi-joint reinforced rock specimen was carried out with a fully grouting bolt. The mechanical properties and failure modes of these specimens are investigated. The experimental results show that the rock bolts can significantly improve the strength of jointed rock-like specimens. When the joint angle is 30° and the anchorage angle is 0°, the peak strength of the specimen increased by 80.76 %, and Young’s modulus increased by 117.83 %. The peak strength of the bolted rock-like specimen decreases with the increase of anchorage angle and increases with the increase of joint angle. The stress at the onset of dilatancy of the rock specimens clearly increases after the rock bolt is applied, and it decreases as the anchorage angle increases. The rock-like specimens after bolting show better ductility and integrity, and the specimens show apparent volumetric dilatation during failure. A strain-softening model of rock and the pile element in FLAC3D are used to carry out numerical simulations (Itasca Consulting Group, Inc. 2012). The mechanical characteristics obtained by the simulation are consistent with the laboratory results.
Spontaneous Activity Patterns in Human Attention Networks Code for Hand Movements
Authors: Zhang Lu , Pini Lorenzo , Kim DoHyun , Shulman Gordon L. , Corbetta Maurizio 
Published: February 2023

Recent evidence suggests that, in the absence of any task, spontaneous brain activity patterns and connectivity in the visual and motor cortex code for natural stimuli and actions, respectively. These “resting-state” activity patterns may underlie the maintenance and consolidation (replay) of information states coding for ecological stimuli and behaviors. In this study, we examine whether replay patterns occur in resting-state activity in association cortex grouped into high-order cognitive networks not directly processing sensory inputs or motor outputs. Fifteen participants (7 females) performed four hand movements during an fMRI study. Three movements were ecological. The fourth movement as control was less ecological. Before and after the task scans, we acquired resting-state fMRI scans. The analysis examined whether multivertex task activation patterns for the four movements computed at the cortical surface in different brain networks resembled spontaneous activity patterns measured at rest. For each movement, we computed a vector ofrvalues indicating the strength of the similarity between the mean task activation pattern and frame-by-frame resting-state patterns. We computed a cumulative distribution function ofr2values and used the 90th percentile cutoff value for comparison. In the dorsal attention network, resting-state patterns were more likely to match task patterns for the ecological movements than the control movement. In contrast, rest-task pattern correlation was more likely for less ecological movement in the ventral attention network. These findings show that spontaneous activity patterns in human attention networks code for hand movements.SIGNIFICANCE STATEMENTfMRI indirectly measures neural activity noninvasively. Resting-state (spontaneous) fMRI signals measured in the absence of any task resemble signals evoked by task performance both in topography and inter-regional (functional) connectivity. However, the function of spontaneous brain activity is unknown. We recently showed that spatial activity patterns evoked by visual and motor tasks in visual and motor cortex, respectively, occur at rest in the absence of any stimulus or response. Here we show that activity patterns related to hand movements replay at rest in frontoparietal regions of the human attention system. These findings show that spontaneous activity in the human cortex may mediate the maintenance and consolidation of information states coding for ecological stimuli and behaviors.
Efektivitas Pemanfaatan Aplikasi Tik Tok Sebagai Media Pembelajaran Jarak Jauh Dalam Meningkatkan Kemampuan HSKK Peserta Didik
Authors: Marsuki Ria Riski , Sukma Sukma , Naqiyah Mardhiyyatin 
Published: February 2023

Penelitian ini merupakan salah satu upaya dalam memaksimalkan proses pembelajaran jarak jauh yang tengah berlangsung di masa pandemi. Tujuan penelitian ini adalah untuk menganalisis efektivitas pemanfaatan aplikasi tiktok sebagai media pengumpulan tugas dalam meningkatkan kemampuan HSKK peserta didik. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan menggunakan instrumen HSKK yang dilaksanakan secara online. Desain penelitian yang akan digunakan adalah pretest-posttest design dengan memberikan tugas pada peserta didik dan mengunggah menggunakan media aplikasi Tik Tok. Hasil dalam penelitian ini adalah menunjukkan bahwa pada masa pandemik kemampuan belajar siswa menurun sehingga test HSKK para peserta didik tidak menujukkan nilai yang maksimal tetapi setelah menggunakan aplikasi Tik Tok sebagai media dalam pengumpulan tugas peserta didik menujukkan adanya peningkatan nilai test HSKK. Hal ini ditandai dengan nilai skor HSKK peserta didik yang meningkat sebanyak 19 persen selama pemberian tugas menggunakan aplikasi Tik Tok. Oleh karena ini dapat disimpulkan bahwa pemanfaatan aplikasi Tik Tok cukup efektif sebagai media pembelajaran jarak jauh untuk meningkatkan kemampuan HSKK peserta didik. This study aims to analyze the effectiveness of TikTok as a medium for collecting assignments in improving students' HSKK abilities. The method used in this study is a quantitative method using the HSKK instrument, which is carried out online. The research design used is a pretest-posttest design by giving assignments to students and uploading them using TikTok. The results show that during the pandemic, students' learning abilities decreased so that the HSKK test does not show the maximum value, but after using the TikTok application as a medium in collecting student assignments, it shows an increase in the HSKK test score. This is indicated by the students' HSKK scores which increases by 19 per cent during the assignment using TikTok. Therefore, it can be concluded that TikTok can be used as a distance learning medium to improve students' HSKK learning abilities.
Equity in Receipt of a Lumbar Puncture for Febrile Infants at an Academic Center
Authors: Taft Maia , Garrison Jessica , Fabio Anthony , Shah Neema , Forster Catherine S. 
Published: February 2023

Background
The evaluation of febrile infants ≤60 days of age is often guided by established protocols. However, structural racism and physicians’ implicit bias may affect how such clinical guidelines are applied.

Objective
To determine the association between self-identified race, insurance type, ZIP code–based median household income (MHI) and receiving a guideline-concordant lumbar puncture (GCLP) in febrile infants.

Methods
This was a 3-year retrospective cross-sectional study of all febrile infants ≤60 days old presenting to a children’s hospital from 2015 to 2017. GCLP was defined as obtaining or appropriately not obtaining a lumbar puncture as defined by the hospital’s clinical practice guideline, which recommended performing a lumbar puncture for all febrile infants ≤60 days of age unless an infant was &gt;28 days of age and had respiratory syncytial virus-positive bronchiolitis. Univariate analyses were used to identify variables associated with receiving a GCLP. Variables with a P &lt; .1 were included in a multivariate logistic regression with race, MHI, and insurance type.

Results
We included 965 infants. Age (adjusted odds ratio, 0.95; 95% confidence interval, 0.94–0.97) and temperature on arrival (adjusted odds ratio, 1.36; 95% confidence interval, 1.04–1.78) were significantly associated with receipt of a GCLP. Self-identified race, insurance type, and MHI were not associated with receiving a GCLP.

Conclusion
Receipt of a GCLP was not associated with race, MHI, or insurance type. As recent national guidelines change to increase shared decision-making, physician awareness and ongoing assessment of the role of factors such as race and socioeconomic status in the clinical evaluation and outcomes of febrile infants will be critical.
MİLLÎ MÜCADELE’DE KULLANILAN İLETİŞİM KAYNAKLARI: URFA SAVUNMASI ÖRNEĞİ
Authors: AKALIN İbrahim Engin 
Published: February 2023

Millî Mücadele dönemi iletişim bilimi açısından incelendiğinde tarihsel olarak belli bir zaman diliminde yaşanmış geçmiş olay bilgisinden ziyade günümüze de ışık tutan bir veri analizini ortaya çıkarmaktadır. İletişim kanallarının kontrolü ve kaynak çeşitliliğinin mücadeleye etkisi, taraflar için taşıdığı önemin yanı sıra sonuca ulaşmada oynadığı rol oldukça dikkate değerdir. Mücadeledeki iletişim faaliyetleri, daha çok tarih çalışmaları çerçevesinde olayları irdeleyen belgeler niteliğinde ele alınmıştır. İletişim alanında ise konuya dair çok sınırlı sayıda araştırma bulunmaktadır. Oysa ki işgal kuvvetleri ile Kuvayı Milliye arasındaki mücadele süreci, iletişim kaynaklarının kullanımı ile şekillenmiştir. Bu nedenle Millî Mücadele’nin iletişim bağlamında araştırılması sebep ve sonuçların daha iyi anlaşılmasını ve yaşanan süreçlerin güncel gelişmeler ışığında olgusal açıdan yeniden değerlendirilmesini kolaylaştıracaktır. Millî Mücadele’de kullanılan iletişim kaynakları Urfa Savunması örneğinde tarihsel araştırma yöntemiyle incelenmiş, literatür taraması sonucunda ulaşılan veriler sınıflandırılarak bir sentez oluşturulmuştur. Oluşturulan sentez tarihsel örgüyle olay-kanıt ilişkisi ekseninde sunulmuştur. Çalışmamızın temel amacı konuya dair temel oluşturarak ilgili araştırmalar için bir kaynak sağlamaktır. Bu nedenle incelemenin genel bir çerçeve oluşturması adına Urfa’nın işgali sırasında işgal kuvvetleri ve yerel direnişçilerin ne şekilde iletişim sağladığı üzerine yoğunlaşılmıştır.
Efficacy of Oral Gabapentin and Intravenous Paracetamol for Postoperative Analgesia in Laparoscopic Surgeries: A Prospective Randomised Double Blind Study
Authors: Kadyan Nishu , Aggarwal Reema , Prasad Ramnandan 
Published: February 2023

Background: Post-operative pain is a matter of great concern for anaesthesiologists and surgeons. We compared the efficacy of oral Gabapentin and intravenous Paracetamol for postoperative analgesia in patients undergoing laparoscopic surgeries.
Methods: After obtaining written informed consent and ethical committee approval, a total of 70 patients undergoing laporoscopic surgeries were randomly allocated into two groups- 35 patients included in Group A were given 600 mg oral Gabapentin 2 hours before the surgery and Group B patients were given 1gm I.V. PCM 30 minutes before the surgery. The NRS scores at 30 min, 2 hours, 6 hours, 8 hours, 12 hours, and 24 hours were recorded. The time at which first rescue analgesic given and Different hemodynamic parameters like heart rate, blood pressure and oxygen saturation were also recorded at different time intervals.
Results: NRS scores and MAP was higher in Group B with a significant p-value at 8 and 12 hours. The need of first rescue analgesic required was at 7.79±3.49 hours in Group A. In Group B requirement of first rescue analgesia was at 6.09±2.75 hrs. The total dose of tramadol used was significantly higher in Group B with mean 92.86±36.67 than Group A 64.29±28.62 with statistically significant p-value (p=0.001).
Conclusion: Both oral Gabapentin and intravenous Paracetamol are effective modes of postoperative analgesia hence both can be used as preemptive analgesic agents. Oral Gabapentin has a longer duration of action up to 12 hours in the postoperative period while intravenous Paracetamol is effective up to 6 hours postoperatively.
Antigenicity and immunogenicity of SARS-CoV-2 surface glycoprotein fragment in CHO cells
Authors: Karimi Sahar , Nazarian Shahram , Sotoodehnejadnematalahi Fattah , Dorostkar Roohollah , Amani Jafar 
Published: February 2023

Background and Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein that projects from the virus surface is highly immunogenic. It is considered to be the target of many neutralizing antibodies as well as a target in vaccine design efforts. Evaluation the immunogenicity of a recombinant fragment of the spike protein (rfsp) that is comprised of Receptor Binding Domain (RBD), S1/S2 cleavage site, and fusion peptide (FP) as immunogenic proteins of SARS-COV-2, in BALB/c mice and evaluation of the efficacy of epitopes rfsp as a multi-subunit chimeric vaccine.
Materials and Methods: The present study made use of CHO-K1 (Chinese hamster ovary K1) cells to create a cell line for constant expression rfsp. The rfsp was purified with Ni-NTA chromatography and confirmed by Western blotting. The immunogenicity and neutralizing antibody efficacy of rfsp were evaluated in BALB/c mice. ELISA was employed to test rfsp via sera of COVID-19 convalescent patients infected with SARS-CoV-2 alpha and delta variants.
Results: Our results showed significant differences in antibody titers in immunized mice compared to the control groups and neutralizing antibodies were positive, sera from mice immunized are capable of bound SARS-CoV-2 virus, chimer peptide is capable bound antibodies patients infected with SARS-CoV-2 and patients infected with delta variant SARS-CoV-2.
Conclusion: Overall, these results indicate that rfsp protein would be a novel potential antigen candidate for the development of a subunit SARS CoV-2 vaccine and rfsp has the potential to be a useful option for the development of the assays for serodiagnosis of SARS-CoV-2 infection.
Videogame “Detonado”: Análise e ranqueamento dos atributos de videogames de nona geração e as diferenças nas preferências entre gênero e faixa etária.
Authors: Nascimento Mario Do 
Published: February 2023

O artigo teve como objetivo descobrir quais atributos são considerados importantes em um videogame de nona geração e qual a relevância destes para o consumidor. Além disso, levantar o perfil sociodemográfico do gamer e verificar as diferenças de preferencias entre os atributos. Para isso, realizou-se uma survey, distribuída nos principais grupos gamers do Facebook, obtendo 404 respondentes. Para verificar as diferenças entre as variáveis sociodemográficas foi utilizado o teste não paramétrico de Wilcoxon-Mann-Whitney e de Kruskal-Wallis. Foram descobertos e ranqueados 39 atributos, bem como percebida diferenças significativas nas notas atribuídas por gênero e faixa etária. Entender os atributos de um produto bem como o perfil de um consumidor é de suma importância não somente para os participantes dessa indústria, mas também para futuros estudos acadêmicos no tema, já que são poucos os estudos nessa área.

Palavras-chave: videogames; atributos; gamer; gênero; jogos
Fiestas del paisaje de la sal artesanal en Chile
Authors: Orozco Salinas Karina 
Published: February 2023

El paisaje de la sal artesanal conforma una red compleja de componentes diseminados en el territorio, en donde las fiestas son una de las capas intangibles que subyace en este paisaje. En efecto, la fiesta forma parte de una dinámica espacial-temporal que contribuye en la construcción de procesos sociales, culturales y territoriales. De esta forma, el interés de esta investigación reside en identificar las fiestas de las salinas en la Zona Central de Chile a fin de estudiarlas desde una perspectiva socioterritorial. Para ello, la metodología se basa en un estudio cualitativo y descriptivo, mediante trabajo de campo, entrevistas y observación directa en las salinas chilenas. Los resultados han revelado que las fiestas salineras son elementos dinámicos, insertos en estructuras territoriales, configurándose como componentes diversificadores del paisaje de la sal, por lo cual resulta fundamental su comprensión como hechos festivos interconectados, evolutivos e integrantes de una red socioterritorial del paisaje.
Stroke Risk Factor Profile in an Urban Population: A Community-Based Descriptive Study in Mojo Sub-District, Surabaya, Indonesia
Authors: Ikhtiar Ilham , Rosyich Muhammad Wijdan , Ardhanu Muhammad Arief , Bastiana Dewi Setyaning , Kurniawan Dedy , Setyowatie Sita 
Published: February 2023

Highlight:

The stroke risk of the urban population in Mojo sub-district, Surabaya, was high (more than 10% risk for 36.3% of the population) .
The risk factor for stroke is highly prevalent in Indonesia's urban communities, such as Surabaya.
The Indonesian version of the Cardiovascular Disease Risk Index chart aids in determining stroke risk factors.
The development of a stroke-spesific index chart has been done before but requires validation for the Indonesian population

ABSTRACT
Introduction: Stroke is still a major cardiovascular disease in Indonesia. Locally published data regarding stroke risk factors is still rarely reported. This condition complicates the regulation, policy-making, and community empowerment efforts to reduce modifiable stroke risk factors. Thus, a study is necessary to provide an overview of stroke risk factors and risks in cities in Indonesia, such as Surabaya. Objective: This study aimed to describe stroke risk factors in an urban Indonesian community, such as the Mojo sub-district in Surabaya. Methods: This was a descriptive study to describe stroke risk factors like age, gender, history of comorbidities, and history of cardiovascular disease, as well as patient clinical data like neurological symptoms, cardiovascular symptoms, anthropometry, vital signs, simple laboratory values, and cardiovascular risk categorization in the next ten years based on the Cardiovascular Disease Risk Index chart, Indonesian version. Results: In this study, 33 participants were included. Risk factors showed that many participants had histories of active smoking (18.2%), hypertension (45.5%), and diabetes (24.2%). One-third of the participants had a history of dyslipidemia. Based on the risk chart for cardiovascular disease, 36.3% of participants were at >10% risk of developing cardiovascular disease in the next ten years. Conclusion: The risk index of cardiovascular disease in the Mojo sub-district, Surabaya, was still high. A combination of government policies, public awareness improvement, and community empowerment are urgently required to manage these risk factors epidemiologically.