bluuebunny/crossref_metadata_2025_split huggingface dataset:
BIN3rs2280104 T allele is associated with excessive daytime sleepiness and altered network topology in Parkinson’s disease
Authors: Chen Zhichun , Wu Bin , Li Guanglu , Zhou Liche , Zhang Lina , Liu Jun 
Published: July 2023

AbstractBackgroundExcessive daytime sleepiness (EDS) is one of the most common non-motor symptoms in Parkinson’s disease (PD). Previous studies showed that PD patients with EDS exhibited more severe motor and non-motor symptoms. Our recent studies revealed thatBIN3rs2280104 was negatively associated with scores of Epworth Sleepiness Scale (ESS) in PD patients. The objective of this study is to examine whetherBIN3rs2280104 shapes brain networks of PD patients and whether network metrics associated withBIN3rs2280104 mediate the effects ofBIN3rs2280104 on EDS.MethodsPD patients (n = 144) receiving functional magnetic resonance imaging in Parkinson’s Progression Markers Initiative (PPMI) database were investigated. The clinical manifestations and graphical metrics of structural and functional network were compared among different genotype groups ofBIN3rs2280104. The mediation analysis was used to explore the causal associations between network metrics modified byBIN3rs2280104 and EDS of PD patients.ResultsESS scores were associated with more severe motor and non-motor symptoms.BIN3rs2280104 T allele was negatively associated with ESS scores in PD patients. Additionally,BIN3rs2280104 significantly shaped structural and functional network metrics of PD patients. The nodal Cp of left superior temporal pole in functional network and the degree centrality of left calcarine in structural network were negatively associated with ESS scores, however, only the degree centrality of left calcarine in structural network mediated the effects ofBIN3rs2280104 on EDS of PD patients.ConclusionsTo summarize,BIN3rs2280104 is significantly associated with EDS and network topology of PD patients. Additionally, the degree centrality of left calcarine in structural network mediated the effects ofBIN3rs2280104 on EDS. Future studies were required to identify the molecular mechanisms underlying the effects ofBIN3rs2280104 on EDS and brain network metrics of PD patients.
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature inC9orf72ALS/FTD neurons
Authors: Milioto Carmelo , Carcolé Mireia , Giblin Ashling , Coneys Rachel , Attrebi Olivia , Ahmed Mhoriam , Harris Samuel S. , Lee Byung Il , Yang Mengke , Nirujogi Raja S. , Biggs Daniel , Salomonsson Sally , Zanovello Matteo , Oliveira Paula De , Katona Eszter , Glaria Idoia , Mikheenko Alla , Geary Bethany , Udine Evan , Vaizoglu Deniz , Rademakers Rosa , van Blitterswijk Marka , Devoy Anny , Hong Soyon , Partridge Linda , Fratta Pietro , Alessi Dario R. , Davies Ben , Busche Marc Aurel , Greensmith Linda , Fisher Elizabeth M.C. , Isaacs Adrian M. 
Published: July 2023

AbstractA GGGGCC repeat expansion inC9orf72is the most common genetic cause of ALS and FTD (C9ALS/FTD). The presence of dipeptide repeat (DPR) proteins, generated by translation of the expanded repeat, is a major pathogenic feature of C9ALS/FTD pathology, but their most relevant effects in a physiological context are not known. Here, we generatedC9orf72DPR knock-in mouse models characterised by physiological expression of 400 codon-optimised polyGR or polyPR repeats, and heterozygousC9orf72reduction. (GR)400 and (PR)400 knock-in mice exhibit cortical neuronal hyperexcitability, age-dependent spinal motor neuron loss and progressive motor dysfunction, showing that they recapitulate key features of C9FTD/ALS. Quantitative proteomics revealed an increase in extracellular matrix (ECM) proteins in (GR)400 and (PR)400 spinal cord, with the collagen COL6A1 the most increased protein. This signature of increased ECM proteins was also present in C9ALS patient iPSC-motor neurons indicating it is a conserved feature of C9ALS/FTD. TGF-β1 was one of the top predicted regulators of this ECM signature and polyGR expression in human iPSC-neurons was sufficient to induce TGF-β1 followed by COL6A1, indicating TGF-β1 is one driver of the ECM signature. Knockdown of the TGF-β1 or COL6A1 orthologue inDrosophiladramatically and specifically exacerbated neurodegeneration in polyGR flies, showing that TGF-β1 and COL6A1 protect against polyGR toxicity. Altogether, our physiologicalC9orf72DPR knock-in mice have revealed a neuroprotective and conserved ECM signature in C9FTD/ALS.
Association between serum LDL‐C concentrations and risk of diabetes: A prospective cohort study
Authors: Huang Jiaojiao , Lin Hong , Wang Shuangyuan , Li Mian , Wang Tiange , Zhao Zhiyun , Xu Yu , Xu Min , Lu Jieli , Chen Yuhong , Ning Guang , Wang Weiqing , Bi Yufang , Wang Long 
Published: July 2023

AbstractBackgroundLow‐density lipoprotein cholesterol (LDL‐C) and diabetes mellitus are both modifiable risk factors for cardiovascular disease; however, whether elevated LDL‐C levels confer a risk for diabetes remains unclear.ObjectiveWe aimed to examine the association between serum LDL‐C concentrations at baseline and the risk of developing diabetes at follow‐up in the general population of Chinese adults.MethodsThis study included 5274 adults aged ≥ 40 years from a community cohort who were without diabetes and followed for a median of 4.4 years. A standard 75‐g oral glucose tolerance test was conducted at baseline and follow‐up visits to diagnose diabetes. Logistic regression models and a restricted cubic spline were used to examine the association between baseline serum LDL‐C levels and the risk of diabetes development. Subgroup analyses were conducted stratifying on age, sex, body mass index, hypertension, family history of diabetes, and LDL‐C levels.ResultsA total of 652 participants (12%) developed diabetes during the follow‐up period. Compared to quartile 1 of serum LDL‐C, quartiles 2, 3, and 4 were associated with a 30%, 33%, and 30% significantly higher risk of diabetes, respectively after adjustment for confounders including homeostatic model assessment for insulin resistance. The linear relationship between baseline LDL‐C down to 30.1 mg/dL and incident diabetes was demonstrated by restricted cubic spline analysis, and each 1‐SD increase in LDL‐C concentration (28.5 mg/dL) was associated with a 12% increase in the risk of diabetes (odds ratio 1.12, 95% confidence interval 1.03–1.22).ConclusionIn this community‐based general population, higher serum LDL‐C levels were linearly associated with an elevated risk of incident diabetes.
Association between daily aspirin therapy and risk of hepatocellular carcinoma according to metabolic risk factor burden in non‐cirrhotic patients with chronic hepatitis B
Authors: Lee Cheol‐Hyung , Lee Yun Bin , Moon Hyemi , Chung Jong‐Won , Cho Eun Ju , Lee Jeong‐Hoon , Yu Su Jong , Kim Yoon Jun , Lee Juneyoung , Yoon Jung‐Hwan 
Published: July 2023

SummaryBackgroundSeveral studies have demonstrated chemopreventive effects of aspirin against hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB).AimsTo investigate the associations of aspirin use with risks of HCC, liver‐related mortality, and major bleeding according to metabolic risk factor burden among non‐cirrhotic patients with CHBMethodsUsing the Korean National Health Insurance Service database, we identified 282,611 non‐cirrhotic adults with CHB. Data on obesity, diabetes, high blood pressure, and hypercholesterolemia were collected. Subjects were stratified into lower and higher metabolic risk groups (≤2 and ≥3 risk factors, respectively). Propensity score‐matched cohorts of aspirin users and non‐users were generated. Risks of HCC, liver‐related death and major bleeding were analyzed.ResultsDuring the median follow‐up of 7.4 years, positive associations between metabolic risk factor burden and outcomes were verified (all ptrend < 0.001). In the lower metabolic risk group (13,104 pairs), the association between aspirin use and HCC risk was not significant after multivariable adjustment (adjusted subdistribution hazard ratio [aSHR]: 0.93; 95% CI: 0.84–1.03); however, aspirin use was associated with elevated major bleeding risk (aSHR: 1.22; 95% CI: 1.08–1.39). In the higher metabolic risk group (2984 pairs), aspirin use was associated with reduced risks of HCC (aSHR: 0.72; 95% CI: 0.57–0.91) and liver‐related mortality (aSHR: 0.69; 95% CI: 0.50–0.96) without an increase in risk of major bleeding (aSHR: 1.02; 95% CI: 0.79–1.32).ConclusionsAspirin therapy was associated with reduced risks of HCC and liver‐related death without excess risk of major bleeding, in non‐cirrhotic patients with CHB who had a higher metabolic risk factor burden.
Current situation of allergological health care at German hospitals
Authors: Hollstein Moritz Maximilian , Schober Anna , Treudler Regina , Becker Sven , Epping Jelena , Hamelmann Eckard , Taube Christian , Wagenmann Martin , Wedi Bettina , Worm Margitta , Zink Alexander , Buhl Timo , Werfel Thomas , Traidl Stephan 
Published: July 2023

SummaryBackgroundAllergic medical care in Germany is organized on an interdisciplinary basis. An overview of the current care situation is necessary to manage and improve interdisciplinary cooperation.MethodsBetween January and February 2022, questionnaires were sent online and by mail to chief physicians of inpatient clinical departments to which most allergological diseases are assigned (dermatology, otorhinolaryngology [ENT], pulmonology, pediatrics, environmental/occupational medicine, gastroenterology; n = 899).ResultsThe response rate was 52.1%. Allergology departments of dermatology, ENT and pulmonology were predominantly located in metropolitan areas (> 100,000 inhabitants), whereas responses of pediatric departments were mostly from smaller towns. 76.8% of the respondents reported existing interdisciplinary treatment plans with other specialties. Pediatric and pulmonology clinics stated disproportionately few interdisciplinary treatment concepts with dermatology and ENT clinics, especially in smaller cities with < 100,000 inhabitants. Diagnosis and therapy of allergic rhinitis were performed in particular by the departments of ENT, asthma mainly by the pulmonology departments. Care of other allergological diseases was most frequently reported by chief physicians of dermatology and pediatrics.ConclusionsIn metropolitan areas, participating departments provide allergology care in a cooperative manner. A large spectrum of care is covered in cooperation with dermatological clinics. In more rural areas, cooperation is rarer; here, mainly pediatric departments provide allergological care, which may explain the more limited range of services compared to metropolitan areas.
Fabrication and mechanical properties of low‐temperature sintered Al2TiO5 flexible ceramics
Authors: Ma Qian , Shui Anze , He Chao , Zhou Yuqian , Shan Qingliang 
Published: July 2023

AbstractTo lower the sintering temperature and improve the mechanical properties of aluminum titanate (AT, Al2TiO5) flexible ceramics, γ‐Al2O3 is employed to partially replace the α‐Al2O3 as the starting powder. The results show that the addition of γ‐Al2O3 is sufficient to promote the reaction, improve the flexibility, raise the strength, and accelerate the grain growth of AT flexible ceramics when sintered at 1300°C. With that, the combination of optimum fracture strength (∼33.52 MPa) and high flexibility (∼1.05%) is obtained when the addition of γ‐Al2O3 is 20 wt.%. As compared to the virgin, the optimization of 21.67% in fracture strength and 176% in strain can be obtained. It is believed that the increase of crack deflection and branching should take the responsibility. However, the mechanical strength degrades with the increase of sintering temperature, which is caused by the grain defects that reduce the bearing capacity of AT grains and lead to the grain fracture model transition. In addition, the effect of γ‐Al2O3 content on AT grain growth transfers from promotion to inhibition with the increase of sintering temperature. The main reason is that the growth of the nanocrystals at AT grain boundary causes the uneven distribution of the intermediate phase, leading to the roughening transition of the boundary and hence reducing the grain growth rate. On these bases, the grain growth mechanism that dominates by grain boundary is proposed. It is believed that the discovery of this study will provide a new grain growth model and the reference for solving the abnormal grain growth or grain growth stagnation.
Design and evaluation of adapalene microemulsion for transfollicular drug delivery through guinea pig skin
Authors: Salimi Anayatollah , Sharifmakhmalzadeh Behzad , amirabadi Fatemeh safari 
Published: July 2023

AbstractIntroductionAcne vulgaris can be treated topically with adapalene, a synthetic derivative of naphthoic acid with retinoid activity. Adapalene has a very low rate of percutaneous absorption and is almost completely insoluble in water. To obviate this problem, microemulsion (ME) carrier is used. The study's goals were to create and characterize adapalene‐loaded ME and assess the drug's transfollicular route of penetration to see if hair follicles can serve as a conduit for the drug to enter the skin.MethodsAdapalene microemulsions (MEs) are made by combining the right amounts of the cosurfactant (propylene glycol), surfactant (Tween 80 and Span 20), and oil phase (oleic acid–Transcutol P (10:1)). Physical and chemical characteristics of MEs, including droplet size, stability, viscosity, drug release, and in vitro skin permeability via guinea pigs' hairy and non‐hairy skin, were assessed.ResultsThe range of 13.86–56.16 nm was found to be the average droplet size of ME formulations. The range of viscosities was 117–240 cps. The drug release profile reveals that 95.374 percent of the drug was released within the experiment's first 24 h. Compared to the adapalene control (aqueous suspension), all MEs enhanced the adapalene flow through both hairy and non‐hairy skin. The surfactant/cosurfactant ratio had an impact on the amount of drug that passed through both skins because a larger ratio enhanced the adapalene affinity in the follicular route.ConclusionFurthermore, the proportions of the water and oil phases in formulations, as well as the S/C ratio, have a significant impact on the physicochemical characteristics and adapalene permeability across both pathways.
Nurses' work experiences in hospital wards with single rooms: An integrative review
Authors: Søndergaard Susanne Friis , Rasmussen Bodil , Kerr Debra , Frederiksen Kirsten , Redley Bernice , Trueman Melody , Kolbaek Raymond , Laursen Henrik Sehested , Bloomer Melissa J. 
Published: July 2023

AbstractAim and objectiveTo evaluate evidence that examined nurses' work experiences in hospital wards with single rooms. The research question was ‘What does the research tell us about nurses’ work experiences in hospital wards with single rooms?’BackgroundIn the last decades, new hospital builds have moved towards including a high proportion of single rooms. Yet, single rooms create ‘complex environments’ that impact the nurses.DesignA structured integrative review was undertaken of empirical evidence.MethodsOriginal, peer‐reviewed articles, written in English, were sourced from four databases: CINAHL, PubMed, Embase and Web of Science. The initial searches were performed in April 2021 and repeated in December 2022. Quality appraisal was undertaken using the Mixed Methods Appraisal Tool. A narrative synthesis approach was used to analyse the data. Reporting was guided by the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement.ResultsTwelve studies, published between 2006 and 2022, with an international origin, and representing n = 826 nurses, were included in this review. The synthesis revealed mixed perspectives about nurses' work experiences in wards with single rooms. Whilst single rooms are ‘all good in theory (and) a good idea’, the reality was quite different. Synthesised findings are presented in four categories: (i) aesthetics and the physical space, (ii) privacy vs. isolation, (iii) safety, which includes situational awareness and (iv) communication and collaboration.ConclusionThis review describes how single rooms affects nurses' work experience. Whilst nurses shared multiple concerns about single rooms and the challenges they also acknowledged patient preference for the privacy and space afforded by single rooms.Relevance to Clinical PracticeFindings from this review highlight the need for careful planning to maintain and strengthen teamwork, prevent nurses' sense of working in isolation, as well as creating opportunities for mentorship, and collaboration among nurses when working in single‐room settings.
J wave dynamicity during coronary angiography and intracoronary acetylcholine administration
Authors: Aizawa Yoshiyasu , Ohashi Narutaka , Kawamura Akio , Ogawa Satoshi , Aizawa Yoshifusa 
Published: July 2023

AbstractBackgroundJ‐waves may be observed during coronary angiography (CAG) or intracoronary acetylcholine (ACh) administration, but their significance is unknown.MethodsForty‐nine patients, 59.1 ± 11.5 years old and 59% male, were studied on suspicion of vasospastic angina, and J wave dynamicity was compared between CAG and Ach administration.ResultsDiagnostic (≥0.1 mV) or nondiagnostic (<0.1 mV) J waves in 9 and 3 patients, respectively, were augmented, and J waves were newly observed in 2 patients during CAG and Ach administration. Similar changes in the J‐wave amplitude were observed: from 0.10 ± 0.09 mV to 0.20 ± 0.15 mV (p < .002) and from 0.10 ± 0.10 mV to 0.20 ± 0.16 mV (p < .001) during CAG and Ach administration, respectively. J waves were located in the inferior leads and changed only during the right coronary interventions. In the remaining 35 patients, J waves were absent before and during the coronary interventions. Augmentation of J waves was found when the RR interval was shortened in some patients. Injection of anoxic media into the coronary artery might induce a conduction delay from myocardial ischemia that manifests as augmentation or new occurrence of J waves.ConclusionsBoth CAG and intracoronary Ach administration affected J waves similarly in the same individuals. A myocardial ischemia‐induced conduction delay may be responsible for the changes in J waves, but further studies are needed.
Development of a national Zoom‐based lectureship for pediatric transplant hepatology trainees
Authors: Banc‐Husu Anna M. , Bonn Julie , Mavis Alisha M. , Feldman Amy G. 
Published: July 2023

AbstractBackgroundPrevious publications identified a gap in standard education on topics related to advanced hepatology and liver transplantation for pediatric transplant hepatology trainees. The Society of Pediatric Liver Transplantation (SPLIT) Education Committee designed a Zoom‐based lectureship series for all advanced pediatric transplant hepatology trainees. We aim to describe the educational series and feedback from fellow participants.MethodsPediatric transplant hepatology trainees from across the United States and Canada were invited to attend 25 Zoom‐based lectures on a broad list of topics pertaining to pediatric transplant hepatology. At the completion of the lectureship, a 53‐item REDcap survey using single‐answer, Likert‐scale, and open‐ended questions was distributed via email to all participants.ResultsA total of 16 fellows from broad geographic areas responded to the survey. Nineteen percent (n = 3/16) of fellows attended all 25 lectures and 31% (n = 5/16) attended 16–20 lectures. Majority of fellows (88%, n = 14/16) reported the lecture series increased knowledge of liver disease, increased confidence in managing children with liver disease, and aided with board preparation. Additionally, over half of the fellows (81%, n = 13/16) reported the series served as a platform for networking and mentoring from peers and experts in the field. All fellows recommended the lecture series for future fellows.ConclusionThe SPLIT educational lectureship for advanced pediatric transplant hepatology trainees provided a national education curriculum that not only led to increased knowledge and confidence in the diagnosis and management of common conditions encountered in pediatric transplant hepatology but also provided a unique networking and mentorship environment.
Betti numbers and the curvature operator of the second kind
Authors: Nienhaus Jan , Petersen Peter , Wink Matthias 
Published: July 2023

AbstractWe show that compact, ‐dimensional Riemannian manifolds with ‐nonnegative curvature operators of the second kind are either rational homology spheres or flat. More generally, we obtain vanishing of the th Betti number provided that the curvature operator of the second kind is ‐positive. Our curvature conditions become weaker as increases. For , we have , and for , we exhibit a ‐positive algebraic curvature operator of the second kind with negative Ricci curvatures.
Efficacy of aqueous extract of Vernonia amygdalina leaf against strongyle and coccidia infections in sheep
Authors: Bagulo Issah , Ibn Iddriss Abdul-Rahman , Abubakari Mohammed , Nsor Victor Asiedu , Katusime Joshua 
Published: July 2023

Gastrointestinal parasites are developing resistance to various commercial anthelmintics. Hence, the need to explore the efficacies of herbal plants against gastrointestinal parasites. The study was therefore conducted to determine the efficacy of aqueous extract of Vernonia amygdalina leaf against strongyles and coccidia spp. in sheep. A total of 60 sheep were used for the study. The animals were randomly assigned to one of the four groups. Those in group A, B, C, and D were given albendazole (ABZ), 10% aqueous V. amygdalina extract (BL10) , 20% aqueous V. amygdalina extract (BL20), and 10 mL distilled water, respectively. All four treatments were given orally, depending on the body weight of the animals, with the exception of the distilled water, which was constant (10 mL) for each animal. Faecal samples were collected from each sheep and examined using McMaster technique. The data were analyzed using R version 4.2. The study brought to light that the prevalence of strongyles in sheep was 70% in the study area at pre-treatment. BL10 had efficacies of 52.58% and 65.08% against strongyles and coccidia spp., respectively. BL20 produced similar anthelmintic effect against strongyles as ABZ. Strongyle spp. showed resistance against ABZ in the study area.