bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of planar LIF/Mie imaging for droplet sizing characterization of dilute sprays
Authors: Garcia Sébastien , Doublet Pierre , Lempereur Christine , Illac Geoffroy , Stiti² Mehdi , Berrocal² Edouard , Orain Mikael 
Published: April 2023

Abstract
The aim of this work is to investigate the planar LIF/Mie droplet sizing technique from an experimental and theoretical point of view. This technique is a good alternative compared to point measurements (e.g. Phase Doppler Anemometry) or integral approaches (e.g. Laser Diffraction). It allows measurement of the Sauter Mean Diameter over a wide field, providing the spray topology and droplet size in a limited amount of time. Nevertheless, its implementation remains challenging due to the fact that the usual assumptions underlying the technique are not fully valid in practice. To overcome these limitations, an innovative experimental set-up has been developed including the use of a telecentric lens and a TwinCam beam splitter device. The benefit of the key optical elements introduced in the set-up will be discussed and quantified in the paper. In particular, it is shown that the telecentric lens removes angular dependency of the Lorenz-Mie optical signals. This is demonstrated using an ethanol hollow cone spray (seeded with rhodamine 6G) generated from a simplex injector at atmospheric pressure and ambient room temperature. A calibration procedure, based on Phase Doppler Anemometry measurements, is used to convert the LIF/Mie into Sauter Mean Diameter maps. The optical depth of the spray has been measured, exhibiting values less than 0.4, which corresponds to a dilute cloud of droplets where multiple light scattering is not an issue. These effects have been quantified using Monte Carlo simulations. Finally, a study of the injection parameters has been undertaken, showing the robustness and efficiency of the planar LIF/Mie droplet sizing method to obtain two-dimensional maps of the Sauter Mean Diameter.
Hydrogenated amorphous silicon's microstructure and dielectric properties
Authors: Kassmi Mounir , Amlouk Mosbah 
Published: April 2023

Abstract
IR and ellipsometry investigations were used to identify the various hydrogenated compositions in amorphous silicon, where the particular hydrogen concentration is restricted by its own precise vibrational frequency and spatial constraints. As a result of PV concerns, the band gap is dependent on the passivation degree and only infrequently varies below 4 eV. We have proven that some full pictures that influence electrical activity include the level of passivity, the size of the gap, and the proximity of the surrounding areas.
Surgical Repair of Post Myocardial Infarction Ventricular Septal Defect: A Retrospective Analysis of a Single Institution Experience
Authors: Shi Jian , Levett Jeremy , LV Haiyu , Zhang Guoan , Wang Sha , Wei Tao , Wang Zhikun , Zhang Xi , Feng Dawei , Wang Kan , Liu Qiang , Shum-Tim Dominique 
Published: April 2023

Abstract
INTRODUCTION:
Ventricular septal defect (VSD) is a mechanical complication of acute myocardial infarction (MI) with a very high mortality, despite advances in surgical and circulatory support. The tremendous hemodynamic disturbance and the severely fragile myocardium render surgical repair a great challenge. The optimal time of surgical repair with or without circulatory support is still controversial.
OBJECTIVE
The aim of this study is to review our experience with early surgical repair of post-MI VSD in a single major cardiac institution in China.
METHODS
From January 2013 to October 2020, 9consecutive patients presented to our emergency department with a diagnosis of post-MI VSD. Among them, 8 were male, and the mean age was 58 ± 7years. The mean VSD size was 22.5 ± 5.7 mm. In all patients, an intra-aortic balloon pump (IABP)was inserted immediately after admission to cardiac surgery service. All patients were operated within one week of the rupture (range of surgery time 1 to 9 days post-VSR, mean 3.3 ± 2.9 days, and 4 within 24 hours. In 5 cases, the VSD was located superiorly, and 4 cases in the posterior septum.
RESULTS
The overall 30-day mortality was 11% (1/9). All patients underwent urgent percutaneous coronary intervention (PCI), and 5 additional coronary artery bypass grafting (CABG) during VSD repair. There was no death in all 5 patients with anterior septal perforation. One patient with posterior septal perforation died in the operating room due to bleeding from the ventriculotomy site. Three survived patients were diagnosed witha small residual defect and mild left to right shunt post-repair. However, no further intervention was required, and patients remained asymptomatic (NYHA class II in 1 and III in 2).
CONCLUSION
In our experience, early surgical repair of post-MI VSD and concomitant coronary revascularization after hemodynamic stabilization and proper rescucitationcan beachieved with favorable survival and earlyoutcomes.
A non-destructive method to detect pathogens in bumble bees for conservation research
Authors: Tissier Mathilde L. , Blair Cole , MacKell Sarah , Adler Lynn S. , MacIvor J. Scott , Bergeron Patrick , Callaghan Carolyn , Labrie Geneviève , Colla Sheila , Fournier Valérie 
Published: April 2023

Abstract
Wild bees are declining worldwide, and many species are now threatened with extinction. Decline is caused by a combination of threats, including disease spillover from managed bees that reduces health of wild bees. An increasing number of studies thus aim to characterize bee health. The common approaches, however, require sacrificing tens to hundreds of individual bees per site or species, with reports of several thousand individuals collected per study. Considering the widespread need to assess bee health, this sampling approach is not sustainable, especially for endangered populations or species. Here, we propose a non-destructive method to assess parasite loads of wild-caught bumble bees. The standard protocol consists of net-capturing individual bumble bees and placing them in a 10 cm (diameter) petri dish to collect faeces. Although this approach is frequently used in laboratory settings, it is not in the field, because of the low success in collecting faeces. Placing bumble bees in a previously refrigerated cooler, we significantly improved faecal collection in the field from 76% with the standard protocol to 86% with the cooler protocol. We also successfully identified spores and cells of two common gut parasites Crithidia spp. and Vairimorpha spp. in faecal samples. The efficacy of the cooler protocol, combined to the low-cost and widespread availability of the equipment should promote its use in field studies.
Implication for insect conservation: As there are calls to reduce destructive sampling methods in bee research, using the updated cooler protocol will contribute to achieving this goal. This opens future avenues of combining this non-destructive approach to assess bee health with molecular tools.
Establishment of tissue culture regeneration system of Ficus tikoua
Authors: xufei li , li Qianxia , Cui Ying , Liu Tongfei , Zhang Yanni 
Published: April 2023

Abstract
Ficus tikoua Bur. is an ecologically functional perennial vine that belongs to the genus Ficus in the family Moraceae. Vitro cultures are considered crucial for F. tikoua embryo's rapid propagation. The present study aimed to evaluate in vitro F. tikoua organogenesis using stem explants. By comparing different hormones and their ratios, the medium formula suitable for different stages of differentiation was screened, and the tissue culture rapid propagation system was established. The results indicated that the survival rate of explants could reach 82.22% after treating them with 0.1% HgCl2 (plus TWEEN-20) surface disinfection for 14 to 16 minutes. Explants were cultured on MS medium, supplemented with different concentrations of Thidiazoron (TDZ) with 6-Benzylaminopurine (6-BA) and Naphthaleneacetic acid (NAA) to study their efficacy in vitro shoot organogenesis. It was revealed that the combination of 0.5 mg L-1 6-BA, 1 mg L-1 NAA, and 1mg L-1 TDZ is the most effective for callus formation (91.1%) and that the combination of 2 mg L-1 6-BA and 0.5 mg L-1 TDZ is the most effective for adventitious shoot induction (61.11%). The highest number of Bud multiplication was obtained in the medium supplemented with 1 mg L-1 6-BA, 1 mg L-1 NAA, and 0.5 mg L-1 TDZ, which yielded a 6.05 proliferation factor. The obtained shoots were rooted easily on a half-strength MS medium, containing 1 mg L-1 IBA and 0.1mg L-1 NAA(68.52%). The cultivation substrate ratio was garden soil: perlite: vermiculite = 2: 1: 1, and the survival rate was 86.17%.
Treatment Optimization by Monitoring Vancomycin Concentration in the Serum and Cerebrospinal Fluid in a Child with Cystoperitoneal Shunt-related Infection Caused by Methicillin-resistant Staphylococcus aureus: A case report
Authors: MIZUNO Shinsuke , KOYAMA Junji , KUROSAWA Hiroshi , KASAI Masashi 
Published: April 2023

Abstract
Background

Cerebral ventricular shunt infections caused by methicillin-resistant Staphylococcus aureus (MRSA), especially strains with elevated minimal inhibitory concentration (MIC) values, have a poor prognosis. Monitoring serum vancomycin (VCM) levels with therapeutic drug monitoring and maintaining high VCM concentrations in the cerebrospinal fluid (CSF) are critical to treatment success. However, there have been a few reports about CSF penetration and the pharmacokinetics of VCM in children.

Case presentation

Here, we report a pediatric case with cystoperitoneal shunt-related meningitis caused by MRSA with an MIC of 2 µg/mL. The adequate VCM concentration was maintained by monitoring the VCM concentration in the CSF via the external ventricular drain, and frequent blood taking was avoided. VCM showed a good CSF penetration in our patient, and she was discharged without complications.

Conclusions

Therapeutic drug monitoring of VCM concentration in the CSF may result in successful treatment even if MRSA shows a higher MIC. Therapeutic drug monitoring of VCM concentration in the CSF may also reduce the frequency of blood collection and side effects.
Machine Learning-Based Malware Detection for IoT Devices: Understanding the Evolving Threat Landscape and Strategies for Protection
Authors: Ali Muhammad Mumtaz , Maqsood Faiqa , Hou Weiyan , Wang Zhenfei , Hameed Khizar , Zia Qasim 
Published: April 2023

Abstract
The Internet of Things (IoT) has experienced significant growth in recent years, with IoT connections surpassing those of traditional connected devices in the last few years. However, with this growth comes an increased risk of IoT security breaches as cybercriminals take advantage of lax security measures at the endpoint level. One of the main challenges in IoT security is the lack of proper protocols, policies, and procedures to protect these devices from malware and malicious software. This review article focuses on the recent advancements in machine learning-based malware detection techniques for IoT devices. We discuss the challenges of detecting malware in IoT devices, including the limited resources and processing power, as well as the diversity of device types and operating systems. We also review recent machine learning-based malware detection techniques for IoT devices, including deep learning, ensemble learning, and transfer learning, and evaluate their efficiency. This review aims to provide a comprehensive understanding of the current state-of-the-art machine learning-based malware detection techniques for IoT devices, highlighting the potential and limitations of these techniques and the role of analytics in future research directions.
On Weighted k-mer Dictionaries
Authors: Pibiri Giulio Ermanno 
Published: April 2023

Abstract
We consider the problem of representing a set of k-mers and their abundance counts, or weights, in compressed space so that assessing membership and retrieving the weight of a k-mer is efficient. The representation is called a weighted dictionary of k-mers and finds application in numerous tasks in Bioinformatics that usually count k-mers as a pre-processing step. In fact, k-mer counting tools produce very large outputs that may result in a severe bottleneck for subsequent processing. In this work we extend the recently introduced SSHash dictionary (Pibiri, Bioinformatics 2022) to also store compactly the weights of the k-mers. From a technical perspective, we exploit the order of the k-mers represented in SSHash to encode runs of weights, hence allowing much better compression than the empirical en-tropy of the weights. We study the problem of reducing the number of runs in the weights to improve compression even further and give an optimal algorithm for this problem. Lastly, we corroborate our findings with experiments on real-world datasets and comparison with competitive alternatives. Up to date, SSHash is the only k-mer dictionary that is exact, weighted, associative, fast, and small.
A mathematical model to analyze effect of harvesting on predator-prey interaction with Beddington-Deangelis functional response
Authors: - Miswanto , Pranoto Iwan , Merheb Abdel-Razzak 
Published: April 2023

Abstract
In this paper, the stability analysis of the interaction between two populations of a predator-prey model is discussed. The model under study is a modified Lotka-Volterra predator-prey model where the biliary function used to express the interaction between the two populations is replaced by a modified Beddington-DeAngelis functional response. Moreover, the growth in the prey population is updated into a logistic growth. Stability conditions of several equilibrium points have been discussed. This paper also discusses the effect of harvesters on the stability of the equilibrium point. The study is divided into three parts. First, the growth of the prey population is discussed without its interaction with the predator population. Second, the effect of the coexistence of the predator and prey populations on the growth of the latter is discussed. Third, the local stability of the model is deduced from the equilibrium point of the model. Finally, analytical results are supported by numerical simulations and results.
Mathematics Subject Classification 37M20, 37N25
Research on PBFT Consensus Algorithm Based on Reward and Punishment Mechanism
Authors: Zhou Kai , Zhao Weibin , Wei Jingquan , Wang Miaomiao 
Published: April 2023

Abstract
In the blockchain network constructed by the Practical Byzantine Fault Tolerance (PBFT), there are problems that the master node needs to be replaced frequently when the master node and the sub-node break down, and the same information is verified multiple times when the sub-node does not work normally. In response to these problems, the award and penalty mechanism is applied to the PBFT consensus algorithm and supervision nodes are introduced to supervise the master node and the sub-node in the blockchain network. Construct a tripartite evolutionary game model with the master node, suspected sub-node and supervision node as the main body to analyze the changes of the three in reaching the three stable states of normal information transmission, normal information verification, and supervision of other nodes before and after the improvement of the PBFT consensus algorithm, and use Matlab software for simulation calculation. The research result proves that the application of the award and penalty mechanism to the PBFT algorithm can improve the efficiency of the master node and the suspected sub-node in normal information transmission and normal information verification in the blockchain network. And it can also increase the participation proactivity of the master node and the suspected sub-node in information verification and the running for the master node. At the same time, increasing the system reward and the reward value, penalty value, and punishment credit value based on the award and penalty mechanism will also improve their efficiency of reaching normal information transmission and normal information verification, and ultimately ensures that the constructed blockchain network can efficiently achieve the goals of information verification and active participation of nodes in verification.
Heterogeneous effects of cytotoxic chemotherapies for platinum-resistant ovarian cancer
Authors: Nara Katsuhiko , Taguchi Ayumi , Yamamoto Takehito , Hara Konan , Tojima Yuri , Honjoh Harunori , Nishijima Akira , Eguchi Satoko , Miyamoto Yuichiro , Sone Kenbun , Mori Mayuyo , Takada Tappei , Osuga Yutaka 
Published: April 2023

Abstract
Background: Single-agent chemotherapy with or without bevacizumab (Bev) is a standard therapy for platinum-resistant ovarian cancer (PR-OC). However, there is a lack of literature on chemotherapy agent selection in heterogenous PR-OC. Therefore, we aimed to clarify the heterogeneous treatment effects of each chemotherapy agent.
Methods: Patients who underwent single-drug chemotherapy agents or Bev combination therapy for PR-OC between January 2009 and June 2022 were included in this study. We assessed the impact of each chemotherapy agent on the time to treatment failure (TTF) according to histological type, platinum-free interval (PFI), and Bev usage.
Results: A total of 158 patients received 343 different chemotherapy regimens. In patients with clear cell carcinoma/mucinous carcinoma (CC/MC), gemcitabine (GEM) had the strongest effect with a median TTF of 5.3 months, whilst nedaplatin (NDP) had the lowest effect with a median TTF of 1.4 months. In contrast, in the non-CC/MC group, irinotecan (CPT-11) and NDP had a better TTF than GEM and pegylated liposomal doxorubicin (PLD). There were notable differences in the treatment efficacy of NDP according to PFI. Specifically, NDP prolonged the TTF in patients with a PFI ≥3 months. Compared with GEM alone, GEM+Bev tended to prolong the TTF more effectively; however, an additive effect was not observed with PLD+Bev.
Conclusions: This study demonstrated that the effect of chemotherapy agents differed according to the tumor and background characteristics of the patient. Our findings will improve selection of effective therapies for patients with PR-OC by considering their background characteristics.
Genomic profiling and characteristics of a C1 degrading heterotrophic fresh-water bacterium Paracoccus sp. strain DMF
Authors: Maurya Shiwangi , Arya Chetan Kumar , Parmar Nidhi , Sathyanarayanan Nitish , Joshi Chaitanya G. , Ramanathan Gurunath 
Published: April 2023

Abstract
Paracoccus species are metabolically versatile gram-negative, aerobic, facultative methylotrophic bacteria showing enormous promise for environmental and bioremediation studies. Here we report the complete genome analysis of Paracoccus sp. strain DMF (P. DMF) that was isolated from a domestic wastewater treatment plant in Kanpur, India (26.4287°N, 80.3891°E) based on its ability to degrade a recalcitrant organic solvent N, N-dimethylformamide (DMF). The results reveal a genome size of 4,202,269 base pairs (bp) with a G+C content of 67.9%. The assembled genome comprises 4,141 coding sequences (CDS), 46 RNA sequences, and 2 CRISPRs. Interestingly, catabolic operons related to the conventional marine-based methylated amines (MAs) degradation pathway could be functionally annotated within the genome of P. DMF, which is an obligated aerobic heterotroph. The genomic data-based characterization presented here for the novel heterotroph P. DMF aims to improve the understanding of the phenotypic gene products, enzymes, and pathways involved with greater emphasis on facultative methylotrophic motility-based latent pathogenicity.
Causal impact of the Pediatric Rapid Response Team's actions on the reduction of unplanned PICU admissions and non-ICU cardiorespiratory arrest: Using the Google Causal Impact R Package.
Authors: Al-Harbi Samah 
Published: April 2023

Abstract
Background: The Pediatric Rapid Response Team has greatly cut down on unplanned admissions to the PICU, deaths of inpatients, and cardiopulmonary arrests outside of the PICU.There is no published study that shows a link between pediatric rapid response teams and a drop in cardiorespiratory arrests and unplanned PICU admissions due to acute decompensation in children.
Method: Quasi-experimental before-and-after intervention, a cohort study. Single-center, tertiary-level academic hospital, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. From January 2014 to July 2017, a total of 3261 pediatric ward patients were enrolled in this study for the pre-intervention period of 1604 and the post-intervention period of 1657. A pediatric rapid response team consists of a pediatric nurse, a respiratory therapist, a nursing supervisor, and a pediatric intensive care unit (ICU)-trained fellow or attending physician. This team evaluated, treated, and prioritized patients with decompensated conditions based on predetermined standards.
Results: A total of 3281 pediatric ward patients were included in the study. 1604 individuals’ pre-intervention and 1677 individuals’ post-intervention participated. Preintervention lasted from January 1, 2014, to August 30, 2015, and postintervention lasted from September 1, 2015, to July 30, 2017. 471 pediatric rapid response teams have been activated in total. Respiratory distress (138/471, 29.30%), sepsis (105/471, 22.30%), physician concern (65/471, 13.80%), and hematology (32/471, 6.8%) were the most common causes for activation. Furthermore, family concern (3/471, 0.1%) was the least prevalent reason for activation. The relative risk of unplanned PICU admission after intervention was 0.55 (0.48–0.63), p value 0.0001, and cardiorespiratory arrest was 0.02 (0.001-0.32), p value 0.006. On unplanned PICU admission, the estimated causal inference from the fitted Bayesian structural time series model is an absolute effect of -11 (-13, -8.5), a relative effect of -45% (-55%, -36%), and a p value of 0.001. The absolute impact on cardiorespiratory arrest was -1.8 (-2.6, -0.99) and the relative effect was -100% (-145%, -55%) with a p-value of 0.001.
Conclusions: Our experience with pediatric rapid response teams has shown that they are an excellent interventional instrument, and it's a brilliant patient safety initiative that transfers PICU reflexes outside the critical care unit to avoid non-PICU cardiopulmonary arrest and reduces unplanned critical care admissions.