bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polypill: Concept Evolution, Clinical Relevance, and Practical Opportunities
Authors: Голубев С.А. 
Published: June 2023

Пандемия сердечно-сосудистых заболеваний остается ведущей проблемой систем здравоохранения во всем мире. Разработка и внедрение простых, алгоритмизированных и доступных подходов менеджмента сердечно-сосудистыхзаболеваний на основе комплексной коррекции факторов риска является одной из ключевых задач клинической медицины и организации здравоохранения. Одним из перспективных подходов является концепция применения поликомпонентной таблетки (полипилла) в качестве базисного средства сердечно-сосудистойпрофилактики. В данном практико-ориентированном обзоре представлены данные о появлении и эволюции концепции полипилл, приведены результаты клинического изучения и дифференцированного применения фиксированных комбинаций двух и трех базисных антигипертензивных средств, обсуждены перспективы применения полипиллов, содержащих статин. Накопленные к настоящему времени объективные данные указывают на высокую эффективность и безопасность современных поликомпонентных лекарственных препаратов для коррекции сердечно-сосудистогопрогноза. Предложены рабочие алгоритмы дифференцированного выбора политаблетки для первичной профилактики сердечно-сосудистых осложнений с учетом фенотипа пациента и профиля факторов риска. Представлен прогноз дальнейшей эволюции состава полипиллов на ближайшую перспективу.
The cardiovascular disease pandemic remains a leading public health challenge worldwide. Elaborating and implementing simple, algorithmic and affordable approaches to cardiovascular disease management based on a comprehensive correction of risk factors have become one of the key tasks of clinical medicine and public health management. One of the promising approaches is the concept of using a multicomponent tablet (polypill) as a basic means of cardiovascular prevention. This practice-oriented review presents data on the emergence and evolution of the polypill concept, provides the results of clinical study and differentiated use of fixed combinations of two and three baseline antihypertensive agents, and discusses prospects of statin-containing polypills. The objective data accumulated to date indicate high efficacy and safety of modern multicomponent drugs in correcting cardiovascular prognosis. Working algorithms for differentiated choice of a polypill for primary prevention of cardiovascular complications taking into account patient phenotype and risk factor profile are proposed. A forecast for further evolution of polypills composition in the near future is presented.
Esbozo para una interpretación política en El destino del hombre de J. G. Fichte
Authors: Choque Aliaga Osman 
Published: June 2023

El artículo se centra en el escrito Die Bestimmung des Menschen [El destino del hombre] con el fin de poner de manifiesto un conjunto de ideas sobre la política. Dentro de la obra del filósofo, los intérpretes han señalado en contadas ocasiones que de este escrito se desprende una vertiente que conduce a pensamientos acerca de la política. La reflexión sistemática de Johann Gottlieb Fichte sobre el derecho y la política se desarrolla en otras publicaciones o textos de referencia, como por ejemplo, Grundlage des Naturrechts [Fundamento del derecho natural]. En lo que nos ocupa, se intentará hacer visible que Die Bestimmung des Menschen puede leerse en clave política. Por ello, en primer lugar se describirán brevemente el origen de la obra y sus contextos histórico y filosófico, a continuación se expondrán los argumentos que contiene y, por último, se destacarán los respectivos acentos políticos.
President Biden's administration towards the quality of democracy and the rule of law in Poland
Authors: Jureńczyk Łukasz 
Published: June 2023

RESEARCH OBJECTIVE: The aim is to analyze and evaluate the attitude of the American administration to the issue of compliance with the principles of democracy and the rule of law in Poland in the context of the war in Ukraine.
THE RESEARCH PROBLEM AND METHODS: The main question is whether the war in Ukraine influenced the approach of President Biden’s administration to the issue of the quality of democracy and the rule of law in Poland? The analysis is carried out in the perspective of the concept of quality of democracy. The author interviewed American researchers and used the method of analyzing the content of text sources.
THE PROCESS OF ARGUMENTATION: The first part covers a theoretical framework for the quality of democracy and the rule of law. The second part presents a synthetic presentation of the main elements of the dispute in Poland around these values. The next two parts cover the approach of the American administration to legal changes in Poland affecting the quality of democracy and the rule of law.
RESEARCH RESULTS: The war in Ukraine silenced American criticism of Poland. This is because the US strategic security interests take precedence over other values and interests. However, when the war in Ukraine is over, this problem may return and weigh heavily on Polish-American relations, especially if Democrats remain in power.
CONCLUSIONS, INNOVATIONS, AND RECOMMENDATIONS: The political and legal dispute in Poland concerning the quality of democracy and the rule of law contributes to the international discussion on this topic. In the mainstream Western literature, there is a serious criticism of the actions of the Polish authorities, sometimes conducted without taking into account the weaknesses of contemporary liberal democracy. The illiberal trend in Poland and other countries in the region, especially in Hungary, fuels criticism of these actions.
Understanding disorder in the law and jurisprudence (the perspective of legal positivism)
Authors: Peno Michał 
Published: June 2023

RESEARCH OBJECTIVE: The main task involves an attempt to characterize a disordered law and concerns characterizing the most important aspects of the disorder.
THE RESEARCH PROBLEMS AND METHODS: The main task of the article are terminological and conceptual arrangements. Therefore, the method of linguistic analysis was used, adapting conceptions knew in ­theory and philosophy of law to the needs of the analysis of the concept of the disorder.
THE PROCESS OF ARGUMENTATION: Starting from the analysis of the main, known theories of law, concepts and ideas, various cases of disorder of the legal system are identified, both in the political, ethical and purely formal aspects.
RESEARCH RESULTS: The analysis allowed to identify and reconstruct certain specific types of disorder. Law, on many levels – from formal to merits of law – can be a source of moral and ideological chaos. Law may serve intentional destabilization of social life.
CONCLUSIONS, INNOVATIONS, AND RECOMMENDATIONS: Traditionally law is associated with order and consistency rather than disorder and chaos. Nevertheless, the disorder and chaos can be seen as a real and factual part of the law.
Wykwalifikowani uchodźcy z Ukrainy wyzwaniem dla rynku pracy
Authors: Kubiciel-Lodzińska Sabina , Solga Brygida , Filipowicz Maciej 
Published: June 2023

CEL NAUKOWY: Uzyskanie wiedzy w zakresie możliwości wykorzystania kwalifikacji uchodźców z Ukrainy na polskim rynku pracy. Artykuł uzupełnia lukę badawczą odnoszącą się do zagadnień związanych z zatrudnieniem migrantów wojennych zgodnie z posiadanym przez nich wykształceniem. Wskazuje na wyzwania w tym zakresie. To zupełnie nowa perspektywa poznawcza.
PROBLEM I METODY BADAWCZE: Badanie zostało przeprowadzone w marcu–kwietniu 2022 r. wśród 1481 uchodźców z Ukrainy, którzy przybyli do województwa opolskiego. Wykorzystano kwestionariusz ankiety przygotowany w języku ukraińskim, dane zbierano metodą pen and paper interview (PAPI) w urzędach gmin w regionie, a także w centrach zakwaterowania zbiorowego.
PROCES WYWODU: Artykuł rozpoczęto od przeglądu literatury odnoszącej się do badań w zakresie wykorzystania kwalifikacji uchodźców. Następnie omówiono metodę badawczą oraz scharakteryzowano badaną grupę. W kolejnej części omówiono wyniki badań i zawarto dyskusję na temat uwarunkowań i wyzwań dotyczących zatrudnienia uchodźców z perspektywy opolskiego rynku pracy. Zakończono podsumowaniem zawierającym rekomendacje.
WYNIKI ANALIZY NAUKOWEJ: Blisko połowa badanych uchodźców miała wyższe wykształcenie. Znajomość języka polskiego wśród uchodźców była słaba (30,7%), a nawet bardzo słaba (50,8%). Mimo tego niemal połowa z tej grupy osób (49,1%) chciała podjąć zatrudnienie. Wśród osób z bardzo dobrą znajomością języka było to 29,4%. Co więcej, pracowało już 8,4% osób ze słabą znajomością języka i niewiele więcej (11,8%) osób dobrze znających język polski. Wśród wyuczonych zawodów byli ekonomiści, psychologowie i pedagodzy i inżynierowie.
WNIOSKI, INNOWACJE, REKOMENDACJE: Zrealizowane badania wnoszą nową wiedzę w zakresie wyzwań związanych z wykorzystaniem kwalifikacji uchodźców z Ukrainy.. Ustalono, że do barier należą m.in. słaba znajomość języka polskiego oraz zakładana przez uchodźców nietrwałość pobytu (większość badanych planowała powrót do Ukrainy).
Media freedom in Ukraine in the context of constitutional reform
Authors: Palagnyuk Yuliana 
Published: June 2023

RESEARCH OBJECTIVE: This paper discusses whether there have been changes to ensure media freedom in Ukraine in the context of constitutional reform.
THE RESEARCH PROBLEM AND METHODS: This is comparative explanatory research. The author uses a process-tracing method and an observation method to analyze media freedom under the presidential-parliamentary republic during the second term of Kuchma’s presidency and under a parliamentary-presidential republic during Yushchenko’s presidency. I summarize descriptive statistics on such indicators of media freedom as political, economic, and legal environment according to the Freedom House data. I also use the analysis of scholars and other non-governmental organizations.
THE PROCESS OF ARGUMENTATION: The analysis of the political situation in Ukraine explains the reasons for the constitutional reform and the democratization of the media system. I systematize data from the Freedom House reports on the indicators, present the results in a graphic form, and make conclusions from the comparisons.
RESEARCH RESULTS: The study shows that changing the political system to a parliamentary-presidential due to the Orange Revolution intensified reforms guaranteeing media freedom in Ukraine. However, the reforms were not at the level expected by the supporters of the Orange Revolution.
CONCLUSIONS, INNOVATIONS, AND RECOMMENDATIONS: The introduction of the parliamentary-presidential model intensified the competition and conflicts between the presidential and parliamentary-government centers of power. It created polarized and chaotic conditions in journalists’ work. The legal environment for the media has not improved significantly. There was a reduction of political influence on the media. The improvement in the economic environment did not occur because the pressure exerted by the ruling elites on the mass media went from the political to the economic dimension.
In situ X-ray diffraction analysis of intrinsic and extrinsic piezoelectric response in (100)/(001)-oriented tetragonal multidomain Pb(Zr, Ti)O3 films epitaxially grown on Si substrates
Authors: Nakahata Miki , Okamoto Kazuki , Ishihama Keisuke , Yamada Tomoaki , Funakubo Hiroshi 
Published: June 2023

Abstract
(100)/(001)-oriented tetragonal Pb(Zr,Ti)O3 films with different thicknesses of 400 nm, 1000 nm, 1700 nm, and 2000 nm were epitaxially grown on (100)
c
SrRuO3//(100)Pt//(100)ZrO2//Si(100) substrates by pulsed laser deposition. Their ferroelectric and piezoelectric properties were investigated by polarization–electric field and strain–electric field measurements with increasing maximum strength of an applied electric field in a triangular wave. The macroscopic piezoelectric response was quantitatively analyzed with respect to the intrinsic and extrinsic contributions based on in situ X-ray diffraction results under an electric field. The domain switching from the (100)- to the (001)-oriented domain and the out-of-plane lattice compression in the (100)-oriented domain were clearly observed under an electric field, while the out-of-plane lattice deformation of the (001)-oriented domain was negligibly small. Furthermore, the effective piezoelectric response due to domain switching increased with the increasing the film thickness, which is attributed to the decrease in the constraint with the increasing film thickness imposed by the substrate.
A INFLUÊNCIA DA RENDA E DOS PROCESSOS DE GESTÃO PARA A REDUÇÃO DA ROTATIVIDADE EM UMA COOPERATIVA DE CATADORAS E CATADORES NO SUL DO RIO GRANDE DO SUL
Authors: UMPIERRE Marcia Borges , ORESTES Melissa Duarte , CALDASSO Liandra Peres 
Published: June 2023

O trabalho em uma cooperativa é desafiador, pois além de realizar as atividades a qual a cooperativa se propõe ainda deve ser realizar a sua gestão. Ao considerar o setor da reciclagem o desafio é maior ainda, visto que as pessoas que constituem esses empreendimentos normalmente estão à margem da sociedade e possuem demandas imediatas, que exigem processos simplificados para que a cooperativa atinja os seus objetivos. Nesse contexto, o presente trabalho tem como objetivo verificar os fatores que levaram a redução da rotatividade em uma cooperativa de catadoras e catadores no sul do Rio Grande do Sul. Para tanto, analisou-se a cooperativa durante seis anos. A cooperativa é um empreendimento incubado na INEESOL da FURG, e no decorrer dos anos de incubação passou por diversas situações, desde o aprimoramento dos processos de gestão administrativa, financeira, e do setor produtivo. Os resultados apontam que os motivos pelos quais atualmente a rotatividade na cooperativa é praticamente inexistente, são: um incremento na renda em mais de 500%, resultando em maior qualidade de vida tanto do cooperado como de seus familiares; o acesso a todas as informações financeiras e; a participação efetiva nos processos decisórios.
Histopathological Effect of Annona Muricata Fruit Extract on Methyl nitrosourea -Induced Mammary Gland Carcinoma in Female Albino Mice
Authors: Sabah Abdulhur Aaya , Hamza Fares Bushra 
Published: June 2023

The Annona muricata (Family-Annonaceae) fruit contain annonaceous acetogenins which have an effect on cancer cell as reported in many research studies. This study was aimed to evaluate the effect of methanolic fruit extract of Annona muricata (MFEAM) on breast cancer histology and invasive cell of MNU-induced breast cancer mice. Fifty female albino mice were divided into five groups (of ten each): control; MNU-induced breast cancer; MNU-induced breast cancer + (MFEAM) 200 mg/kg, MNU-induced breast cancer + (MFEAM) 300 mg/kg and MNU-induced breast cancer + (MFEAM) 500 mg/kg. The research indicates that breast cancer invasive ductal carcnoma (IDC) developed in the MNU-induced breast cancer group. The control group showed normal duct structure. The (MFEAM) -treated group showed lower invasive (DCIS) compared with the untreated cancer group. We concluded that (MFEAM), that improved the histological changes of breast cancer-induced MNU. Also (MFEAM) reduced proliferative epitheal cell of breast cancer-induced MNU and the most effective dose was 300 mg/kg. The present study concluded that the methanol extracts derived from Annona muricata fruit potentially exhibit antitumor activity.
The control group showed normal duct structure. The (MFEAM) -treated group showed lower invasive (DCIS) compared with the untreated cancer group, We concluded (MFEAM) that improved the histological changes of breast cancer-induced MNU. Also (MFEAM) reduced proliferative epitheal cell of breast cancer-induced MNU and the most effective dose in 300 mg/kg.
Una Aproximación al Arte Digital.
Authors: Valencia Ramos Arturo 
Published: June 2023

Resumen.
Este artículo presenta de manera general una visión, una aproximación, al arte digital. Se orienta a un público que apenas asoma su interés en el tema que, sin duda, cada vez toma más relevancia, sobre todo si consideramos los más recientes debates en torno a la inteligencia artificial y su impacto a nivel global. La llegada y uso masivo del internet ha contribuido tanto a la producción, la difusión y el almacenamiento de arte digital, en tanto en que se ha convertido es su hábitat natural: la mayoría de la producción digital se difunde en redes sociales y en sitios establecidos con ese fin. En el artículo se afirma que el arte digital ha estado vinculado a los avances tecnológicos y emerge en un período de nuestra historia en el que la tecnología se ha convertido en un elemento fundamental de la cultura y la sociedad.
Mulheres rurais e plantas medicinais: saberes populares e significados na luta pela terra
Authors: Costa Juliana Almeida da , Marin Joel Orlando Bevilaqua 
Published: June 2023

Os saberes populares relacionados às plantas medicinais têm sido de interesse de muitos estudos acadêmicos, assim como temas relacionados às mulheres rurais. Este artigo tem por objetivo compreender como mulheres rurais, integrantes do Movimento dos Trabalhadores Rurais Sem Terra (MST), mobilizam saberes relativos às plantas medicinais, para construção de relações de reconhecimento social no âmbito nas áreas de saúde e educação. Essa pesquisa qualitativa, envolveu seis mulheres assentadas em diferentes regiões do Rio Grande do Sul – RS. Iniciamos abordando as trajetórias de vida e de lutas dessas mulheres relacionadas com as plantas medicinais, seguimos para as relações destas, a partir de seus saberes, com o Sistema Único de Saúde e seus profissionais e encerramos buscando compreender as interlocuções delas com escolas do campo. Por fim, compreendemos que essas mulheres entendem seus saberes como primordiais para a vida no planeta, transformando suas vidas e construindo processos emancipatórios.
PENGEMBANGAN ANALISIS SWOT DALAM PERENCANAAN STRATEGIK PROGRAM SEKOLAH PENGGERAK SEKOLAH DASAR DI KOTA SEMARANG
Authors: Iswandi  , Ayu Nyoman Ngurah , Egar Ngasbun 
Published: June 2023

Penelitian ini memiliki tujuan dari penelitian ini untuk: 1) Mengetahui deskripsi analisis SWOT dalam strategik perencanaan Program Sekolah Penggerak yang digunakan di Sekolah Dasar selama ini di Kota Semarang. Penelitian yang digunakan dalam pelitian ini adalah pendekatan kualitatif. Jenis penelitian yang dilakukan adalah penelitian pengembangan (Research & Development). Penelitian ini mengambil lokasi di Sekolah Penggerak jenjang SD di wilayah Kecamatan Gajahmungkur, Kota Semarang (SDN Karangrejo 01 dan SDN Sampangan 01). Penelitian ini menggunakan desain deskriptif-kualitatif. Sumber data yang terlibat pada studi pendahuluan ini adalah kepala sekolah dan guru. Sumber data pada studi ini diantaranya adalah pakar dan praktisi, dosen, dan pihak terkait dari Dinas Pendidikan Kota Semarang. Teknik analis data pada penelitian yaitu melalui tiga aktivitas yaitu Kondensasi data/pemadatan data, tampilan data, dan penarikan kesimpulan. Hasil penelitian adalah Berdasarkan hasil penilaian keenamskor tersebut diperoleh rerata 49,16 dan dinyatakan berkategori baik. Berikut saran dan masukan perbaikan model pengembangan kertas kerja swot dalam perencanaan strategik yaitu: Secara keseluruhan tahapan sudah baik dan urut tetapi perlu diperjelas Kembali dalam desainya, agar arah dan sasaranya tepat, dan secara prinsip sudah runtut namun ketegasan research gap kurang tampak, untuk menguatkan penemuan anda, coba gali dari sumber yang lebih luas agar hasil desain lebih jelas. Simpulan penelitian ini adalah Model pengembangan kertas kerja swot dalam perencanaan strategiksudah efektif dan layak digunakan. Kepala sekolah diharapkan dapat menggunakan kertas kerja swot dalam perencanaan strategik untuk melakukan analisis dalam organisasi
Kata Kunci: Program Sekolah Penggerak, Perencanaan Strategik, Analisis SWOT
Meningkatkan Kompetensi Pedagogik Guru Di Sekolah Dasar Melalui Pengawasan Yang Dilakukan Oleh Kepala Sekolah.
Authors: Kurniawan Feby 
Published: June 2023

ABSTRACT
The purpose of this research is to clarify how school administrators supervise teachers to improve pedagogical skills in the classroom. This study focuses on two issues: (1) how to improve school education by involving the community, and (2) the biggest challenges in content management and teacher development. Data mining and constructive methods were used in this investigation. The results showed that effective methods for managing principals and training teachers consisted of: (1) routine classroom practices, (2) supervision by administrators and educators, (3) floating procedures for describing class visits, and (4) evaluation of leadership activities with the intention of discussing and sharing ideas to improve teaching in the classroom. However, there are also constraints on the capacity of principals to supervise school administrators, including (1) Management issues, such as control of school administrators, teacher anxiety, and educators' lack of understanding of supervision; and (2) The decisions made by the school administration, such as the implementation of action plans, curriculum, teaching resources, teaching strategies, and teaching methods used by teachers in the teaching staff. Due to their busy schedule outside of school hours and the lack of support and incentives for teachers, especially in terms of preparing them for monitoring, the follow-up of school administrators was inadequate. Principals, teacher pedagogic competence, and monitoring are the keywords.
Keywords: supervision, school principals, and teacher pedagogic competence
Influencia en la respuesta al tratamiento de Diabetes en coinfección con tuberculosis, a propósito de un caso
Authors: Venegas Mera Beatriz , Rodríguez Gamboa Mery Susana , Morales Solís Jorge Marcelo , Naranjo Perugachi Jeaneth Del Carmen , Solís Mayorga Jessica Daniela 
Published: June 2023

La tuberculosis es una enfermedad infectocontagiosa, causada por el M. tuberculosis, el ser humano es el principal reservorio. Los determinantes sociales y las condiciones económicas, culturales, la edad, condiciones de salud de la población, comorbilidades, son factores predominantes para la transmisión de la enfermedad, así en nuestro caso la asociación a diabetes mellitus contribuyó a que esta enfermedad progrese y se disemine, haciendo el manejo terapéutico complejo. Se presenta un [1]caso de una paciente con tuberculosis, con comorbilidad de diabetes mellitus , se empleó el método descriptivo y analítico con la búsqueda de revisión bibliográfica actualizada, enfocados en los temas correspondientes a diabetes mellitus en coinfección con tuberculosis en bases de datos como UpToDate, Cochrane, PubMed entre 2019-2022 y rastreo manual de aquellas referencias más relevantes de artículos seleccionados. Se concluye que la tuberculosis está considerada como una enfermedad de salud pública, los casos de tuberculosis y más en los grupos vulnerables con comorbilidades como la diabetes mellitus, es importante que el personal de salud, tengan una alta sospecha en base a la clínica y así hacer un diagnóstico temprano con lo que se iniciaría el tratamiento específico de manera oportuna y eficiente
Kampus Hijau Berkelanjutan Dalam Perspektif Pendidikan Lingkungan
Authors: Bakaruddin Bakaruddin , Afriyeni Afriyeni , Algusri Jeki 
Published: June 2023

The purpose of this research was to study literature, relating to a sustainable green campus from the perspective of the UI Green Metric education and research category, and gain an understanding of environmental education to students in higher education. In implementing a green campus, there are three related factors in educational activities, that is; First, the relationship between seminar and education activities practice, which can be done by students or universities. Second, the relationship with the green campus campaign can be managed bay universities and students. Third, relationship with the implementation of green campus activities by reducing paper use, and providing short courses on the environment to communities around the campus. Higher education is a party that has considerable influence in determining policy. Higher education has professionals who have studies in solving a problem in the environment field.