bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liver Transplant From a Deceased Donor With Cystinosis: A Case Report
Authors: Taj Raeda , Ng Kim , Cuddapah Sanmati R. , Rand Elizabeth B. , Bleicher Melissa , Amaral Sandra , Hoteit Maarouf A. , Reddy Rajendar K. , Feyssa Eyob , Furth Emma E. , Olthoff Kim M. , Abu‐Gazala Samir , Levine Matthew H. , Vyas Frederick , Abt Peter L. 
Published: January 2025

ABSTRACTMany inherited metabolic disorders (IMD) are associated with end‐organ damage necessitating organ transplantation. Although utilization of deceased donors with history of IMD warrants caution, there may be circumstances under which such donors could be considered as suitable organ donor candidates. We present the first known report of liver transplantation from a deceased donor with cystinosis. The donor was a 20‐year‐old male with infantile cystinosis who had previously undergone two deceased donor kidney transplants. Unfortunately, he incurred cranial trauma, and after careful consideration of the metabolic consequences, his liver was deemed suitable for transplantation. The liver was successfully transplanted into a 65‐year‐old female recipient with hepatitis C (HCV) cirrhosis. The recipient is currently 12 months post‐transplant and experiencing good graft function without evidence of cystine crystals on liver biopsy. This case highlights that liver transplantation from donors with rare IMD can result in favorable outcomes. However, it is crucial to approach the use of such livers with caution. These transplants should be considered after a thorough assessment, ensuring that a comprehensive decision‐making process is in place to mitigate potential risks.
Achieving Construct Clarity Through Perceived Workplace Exclusion: A Critical Literature Analysis and Proposed Model
Authors: Stamper Christina L. , Metz Isabel , Shore Lynn M. 
Published: January 2025

ABSTRACTThere are many researchers who believe that workplace exclusion is a unique construct and worthwhile to study; however, there is also significant inconsistency across existing research in definitions and explanations. These variations illustrate the practical and investigative need for a more precise approach that can be consistently utilized to facilitate a common and deeper understanding of workplace exclusion. To this end, we build a bridge across the different perspectives to establish a clearer conceptual foundation. Our work focuses on the target's belief that they are being excluded, represented by the proposed concept of perceived workplace exclusion. We first analyze definitions and theoretical logic drawn from representative publications found across literatures on exclusion, mistreatment, and diversity by applying Suddaby's criteria for construct clarity. Our results show the presence of multiple definitions, an absence of clear differentiation from similar constructs, confusing contextual descriptions and approaches, and utilization of multiple, inconsistent theoretical perspectives. We then utilize valuable insights from our analysis, along with logic drawn from the perceived organizational membership framework, to craft the concept of perceived workplace exclusion. Through our work, we generate propositions and research questions to stimulate future research efforts that will result in significant theoretical advancement and accumulated knowledge.
Nitrogen Deposition Enhances Interactions Between Litter Types During the Early Stage of Decomposition
Authors: Li Jiahao , Dong Yuxin , Liu Kaixuan , Chen Lingsu , Zhang Xiaoxi , Zhang Yangfei , Yang Enxiu , Wei Lihong 
Published: January 2025

ABSTRACTNitrogen deposition can alter the interactions between litter types during their decomposition, and thus affect material cycling and ecosystem stability. However, it is unclear how the differences in the initial chemical properties of litter mixtures affect their response to nitrogen deposition. In this study, we investigated three litter mixtures: high quality–high quality (Robinia pseudoacacia–Stipa grandis, Rp‐Sg, mixed form F1), high quality–low quality (Rp–Setaria viridis, Rp‐Sv, F2), and low quality–low quality (Artemisia gmelinii–Sv, Ag‐Sv, F3). Each of the litter types can be found in Rp plantations in the Loess Hilly Region, China. We subjected the litter mixtures to nitrogen deposition treatments (0 and 4–12 g·m−2·a−1) in a 326‐day indoor decomposition experiment. Decomposition parameters of each litter type in monospecific and mixed decomposition were compared to investigate the interactions between litter types under nitrogen deposition. The results indicated that, in the early stage of mixed decomposition, litter types of similar substrate quality did not affect the decomposition of each other (i.e., in the F1 and F3 mixtures). In contrast, the decomposition of low‐quality litter (Sv) was accelerated by that of high‐quality litter (Rp) when there was no nitrogen deposition. The overall degree of the mutual effects (Rinter,t) for the litter decomposition rate in F1, which has an overall higher quality, increased and then decreased with increasing nitrogen deposition; whereas the Rinter,t for the litter decomposition rate in F2 and F3, which have an overall poor quality (p < 0.05), increased continuously. In general, nitrogen deposition increased the interactions between litter types during the early stage of mixed decomposition. Given that most interactions were synergistic, this effect of nitrogen deposition may alleviate its inhibitory effects on litter decomposition in the study region.
MScanFit and StairFit Motor Unit Number Estimation of the Extensor Digitorum Brevis and Abductor Digiti Minimi Muscles
Authors: Zhang Yanhui , Chen Maoqi , Xu Peipei , Xie Qing , Zong Ya , Zhou Ping 
Published: January 2025

ABSTRACTIntroduction/AimsMScanFit and StairFit are two motor unit number estimation (MUNE) methods derived from a compound muscle action potential (CMAP) scan. This study aims to compare MScanFit and StairFit MUNE values by applying both methods to the same muscles.MethodsCMAP scans were recorded from the extensor digitorum brevis (EDB) and abductor digiti minimi (ADM) muscles. MUNE was performed using the MScanFit and the StairFit programs.ResultsTwenty healthy subjects (30.1 ± 6.6 years; 11 males, 9 females) participated in the study. The MScanFit and StairFit MUNE values were 79 ± 35 and 63 ± 20 for the EDB muscle, and 124 ± 33 and 80 ± 20 for the ADM muscle, respectively. The StairFit MUNE was significantly lower than the MScanFit MUNE (p < 0.05 for EDB, p < 0.01 for ADM).DiscussionThe different results for MScanFit and StairFit MUNE are likely due to the different strategies used by the two methods. Serial studies are needed to further compare their performances in tracking motor unit number and size changes.
Coblator Assisted‐Barbed Relocation Pharyngoplasty (Co‐BRP) in Obstructive Sleep Apnea Surgical Treatment
Authors: Bahgat Ahmed , Vicini Claudio , Bahgat Yassin , Magliulo Giuseppe , Greco Antonio , De Virgilio Armando , Pace Annalisa , Maniaci Antonino , Lechien Jerome , De Vito Andrea , Cammaroto Giovanni , Caranti Alberto , Casale Manuele , Moffa Antonio , Cocuzza Salvatore , Olszewska Ewa , Perrone Tiziano , Iannella Giannicola 
Published: January 2025

AbstractBarbed reposition pharyngoplasty (BRP) is a new technique to manage velo‐pharyngeal obstruction and collapse in OSA patients. Tonsillectomy is a preliminary step of BRP surgery. Dissection of the PPM with monopolar or hot instruments is an essential step of the BRP technique. Tonsillectomy and muscle manipulation should be managed with careful attention due to the risk of muscle fibers rupture and surgical failure. We describe the coblator assisted BRP. The aim of this paper is to report the use and advantages of coblator technology in tonsillectomy and the velo‐pharyngeal dissection before the PPM relocation with barbed sutures. In this operative technique study 100 OSA patients underwent Co‐barbed technique. The CO‐BRP technique has been considered fast, safe and minimally invasive with a low postoperative pain (mean value 3.63 ± 0.7). Postoperatively, a significant decrease in mean AHI from 35.63 ± 10.57 to 17.06 ± 5.92 (P < .005) emerged.
Are Pollution Control Bonds and Public Ownership Really Blessing for Utility Firms?
Authors: Khanchel Imen , Lassoued Naima , Khiari Cyrine 
Published: January 2025

ABSTRACTThe purpose of this study is to extend the existing literature on the relationship between green financing and carbon footprints in utility firms. We specifically examine the connection between pollution control bonds (PCBs) and carbon efficiency (CE), as well as whether public ownership moderates this relationship. This study is based on the Data Envelopment Analysis (DEA) method with Variable Returns to Scale to measure CE in firms by optimizing inputs while considering both desirable and undesirable outputs. Specifically, the study uses three key input variables: labor, defined by the effective labor time of employees; capital input, calculated using the perpetual inventory method; and energy use, which refers to the final energy consumption. We include good outputs (represented by net sales revenue) and bad outputs (quantified by carbon emissions). Using a sample of 86 US utility firms that use PCBs, matched with an equivalent number of firms from 2011 to 2020, our findings indicate that PCBs increase CE. Furthermore, we observe that public ownership strengthens this relationship, suggesting that utility firms have to consider the role of public ownership when addressing environmental challenges. Sensitivity analysis, taking into account significant reforms such as the Clean Power Plan (CPP) and Affordable Clean Energy (ACE), yields interesting results. The findings during the application periods of both the CPP and ACE align with our primary conclusions, though with some variations. Specifically, the ACE period demonstrates more pronounced effects than the CPP, largely due to ACE's flexible framework, which alleviates financial and regulatory pressures on utility companies. Conversely, the suspension of the CPP yielded contrasting results, with PCBs reducing CE. This result is primarily because many firms continued to depend on traditional energy sources in the absence of new mandatory regulations.
Children's environmental citizen science: Stakeholders' experiences and perceptions
Authors: Wilson Catherine , Mills Sarah , Wood Paul J. 
Published: January 2025

Abstract

Compared to our understanding of adult participation in environmental citizen science (CS), the current literature on child engagement is limited. As adult stakeholders may control children's access to environmental CS (through recruitment strategies, resource provision or as gatekeepers), it is important to understand their experiences and perceptions of engaging children in environmental CS.

Semistructured online interviews were conducted with 26 stakeholders of environmental CS. Stakeholders were individuals and organisations that ran or facilitated projects or used environmental CS data. Template thematic analysis was used to analyse the interview materials.

This research found that the interviewees were generally positive about the engagement of children in environmental CS, with most stakeholders having equal trust in the data collected by adults and children.

Six factors were identified that should be considered when engaging children in environmental CS compared to adults. These were (1) purpose of the project, (2) safety of child participants, (3) supervision of child participants, (4) knowledge and cognitive abilities, (5) attitude and behaviour and (6) commitment to the project.

A novel framework for citizen scientists' outcomes, with a focus on children, was developed based on stakeholders' perceptions and experiences. The categories included within this framework were educational, environmental, scientific, well‐being, societal, social and career outcomes.

Stakeholders perceived that children could contribute to and benefit from environmental CS, which has positive implications for research and practice across different organisational contexts and sectors of society. The six factors perceived as important considerations when involving children in environmental CS can help practitioners engage young people, creating a more inclusive approach to environmental CS. The development of a framework in this research, which highlights the individual and societal outcomes of environmental CS and specifically focuses on children, emphasises outcomes that had been overlooked in previous frameworks and research, providing clear direction for future project evaluations.

Read the free Plain Language Summary for this article on the Journal blog.
Microencapsulation: An Innovative Technology in Modern Science
Authors: Lalarukh  , Hussain Syed Makhdoom , Ali Shafaqat , Yilmaz Ebru , Zahoor Ameer Fawad , Javid Arshad , Alshehri Mohammad Ali , Shahzad Muhammad Mudassar , Naeem Adan , Mahrukh  
Published: January 2025

ABSTRACTMicroencapsulation is a methodology utilized across different areas to upgrade the viability, steadiness, and conveyance of bioactive compounds. Microencapsulation improves stability, controlled release, and sensory properties in pharmaceuticals, food products, agriculture, skincare products, and aquaculture by enclosing molecules within protective coatings. Spray drying, emulsification, and coacervation are techniques employed to tailor the release profiles and safeguard encapsulated compounds. The microencapsulation technique improves the shelf life and effectiveness of bioactive compounds, addressing challenges related to solubility, bioavailability, and targeted delivery. Despite its advantages, microencapsulation faces challenges concerning cost, scalability, and regulatory compliance. Ongoing research aims to enhance these techniques and materials, increasing cost‐effectiveness and facilitating applications in biotechnology, environmental science, and additional domains. This study explores the critical role of the microencapsulation approach in improving the stability and effectiveness of bioactive compounds across various applications, while also considering current challenges and future developments in improving the efficiency of encapsulation methods and materials.
Computational pathology applied to clinical colorectal cancer cohorts identifies immune and endothelial cell spatial patterns predictive of outcome
Authors: Trahearn Nicholas , Sakr Chirine , Banerjee Abhirup , Lee Seung Hyun , Baker Ann‐Marie , Kocher Hemant M , Angerilli Valentina , Morano Federica , Bergamo Francesca , Maddalena Giulia , Intini Rossana , Cremolini Chiara , Caravagna Giulio , Graham Trevor , Pietrantonio Filippo , Lonardi Sara , Fassan Matteo , Sottoriva Andrea 
Published: January 2025

AbstractColorectal cancer (CRC) is a histologically heterogeneous disease with variable clinical outcome. The role the tumour microenvironment (TME) plays in determining tumour progression is complex and not fully understood. To improve our understanding, it is critical that the TME is studied systematically within clinically annotated patient cohorts with long‐term follow‐up. Here we studied the TME in three clinical cohorts of metastatic CRC with diverse molecular subtype and treatment history. The MISSONI cohort included cases with microsatellite instability that received immunotherapy (n = 59, 24 months median follow‐up). The BRAF cohort included BRAF V600E mutant microsatellite stable (MSS) cancers (n = 141, 24 months median follow‐up). The VALENTINO cohort included RAS/RAF WT MSS cases who received chemotherapy and anti‐EGFR therapy (n = 175, 32 months median follow‐up). Using a Deep learning cell classifier, trained upon >38,000 pathologist annotations, to detect eight cell types within H&E‐stained sections of CRC, we quantified the spatial tissue organisation and colocalisation of cell types across these cohorts. We found that the ratio of infiltrating endothelial cells to cancer cells, a possible marker of vascular invasion, was an independent predictor of progression‐free survival (PFS) in the BRAF+MISSONI cohort (p = 0.033, HR = 1.44, CI = 1.029–2.01). In the VALENTINO cohort, this pattern was also an independent PFS predictor in TP53 mutant patients (p = 0.009, HR = 0.59, CI = 0.40–0.88). Tumour‐infiltrating lymphocytes were an independent predictor of PFS in BRAF+MISSONI (p = 0.016, HR = 0.36, CI = 0.153–0.83). Elevated tumour‐infiltrating macrophages were predictive of improved PFS in the MISSONI cohort (p = 0.031). We validated our cell classification using highly multiplexed immunofluorescence for 17 markers applied to the same sections that were analysed by the classifier (n = 26 cases). These findings uncovered important microenvironmental factors that underpin treatment response across and within CRC molecular subtypes, while providing an atlas of the distribution of 180 million cells in 375 clinically annotated CRC patients. © 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Damp‐Heat–Induced Degradation of Lightweight Silicon Heterojunction Solar Modules With Different Transparent Conductive Oxide Layers
Authors: Zhang Kai , Mashkov Oleksandr , Yaqin Muhammad Ainul , Doll Bernd , Lambertz Andreas , Bittkau Karsten , Duan Weiyuan , Peters Ian Marius , Brabec Christoph J. , Rau Uwe , Ding Kaining 
Published: January 2025

ABSTRACTLightweight photovoltaic applications are essential for diversifying the solar energy supply. This opens up vast new scenarios for solar modules and significantly boosts the capacity of renewable energy. To ensure high efficiency and stability of the solar modules, several challenges need to be overcome. Degradation due to elevated temperature and/or humidity is a critical concern for silicon heterojunction (SHJ) solar modules. Here, we investigated the stability and degradation mechanism of encapsulated cells with lightweight configurations where the cells are based on three different types of transparent‐conductive oxide (TCO): indium tin oxide (ITO), aluminum‐doped zinc oxide (AZO), and a combination of ITO/AZO/ITO under humid and thermal environmental conditions. A damp heat (DH) test at a temperature of 85°C and relative humidity (RH) of 85% was performed on lightweight modules for 1000 h. Our results show that AZO is the most susceptible to DH degradation. The AZO film was damaged by the combined effects of moisture ingress and delamination of the interconnection foil, resulting in a decrease in the conductivity of the AZO film, leading to a dramatic increase in Rs and a decrease in FF of the modules. Consequently, moisture has a greater chance of percolating through the damaged AZO layer into the a‐Si:H passivation layer, causing passivation degradation, which leads to an increase in recombination, resulting in a decrease in Voc of the modules. In particular, after capping the AZO film with an ITO film, the efficiency loss of the ITO/AZO/ITO module was significantly reduced. This suggests that the ITO film could be a promising protective capping layer for the AZO‐based solar cells.
The Proteomic Landscape of the Coronary Accessible Heart Cell Surfaceome
Authors: Inocencio Iasmin , Rai Alin , Donner Daniel , Greening David W. 
Published: January 2025

ABSTRACTCell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling and cellular phenotyping in physiological and pathological states. Here, we employed coronary artery perfusion with membrane‐impermeant biotin to label and capture the surface‐accessible proteome in the neo‐native (intact) heart. Using quantitative proteomics, we identified 701 heart cell surfaceome accessible by the coronary artery, including receptors, cell surface enzymes, adhesion and junctional molecules. This surfaceome comprises to 216 cardiac cell‐specific surface proteins, including 29 proteins reported in cardiomyocytes (CXADR, CACNA1C), 12 in cardiac fibroblasts (ITGA8, COL3A1) and 63 in multiple cardiac cell types (ICAM1, SLC3A2, CDH2). Further, this surfaceome comprises to 53 proteins enriched in heart tissue compared to other tissues in humans and implicated in cardiac cell signalling networks involving cardiomyopathy (CDH2, DTNA, PTKP2, SNTA1, CAM, K2D/B), cardiac muscle contraction and development (ENG, SNTA1, SGCG, MYPN), calcium ion binding (SGCA, MASP1, THBS4, FBLN2, GSN) and cell metabolism (SDHA, NUDFS1, GYS1, ACO2, IDH2). This method offers a powerful tool for dissecting the molecular landscape of the coronary artery accessible heart cell surfaceome, its role in maintaining cardiac and vascular function, and potential molecular leads for studying cardiac cell interactions and systemic delivery to the neo‐native heart.
Parenting and Family Concerns of Couples Navigating Advanced Breast Cancer: Exploring Discussions Around Parenting Challenges and Targets for Intervention
Authors: Kroll Juliet L. , Jones Morgan , Ann‐Yi Sujin , Chavez‐MacGregor Mariana , Bruera Eduardo , Milbury Kathrin 
Published: January 2025

ABSTRACTBackgroundParents with advanced cancer and their partners are more likely to experience psychological distress than their counterparts without minor children. Greater relationship functioning may support parents in distress.AimsThe current study seeks to explore couples' cancer‐related parenting communication behaviors, perception and their associations with psychological and relational wellbeing.MethodsWomen diagnosed with an advanced breast cancer (Stage III‐IV) and their partners (n = 46 dyads) parenting a minor child reported psychological symptoms (CES‐D, GAD‐7), relational wellbeing (DAS‐7) and cancer‐related parenting concerns (PCQ, patient only). As part of an observational task, couples completed a Family Concern Inventory (FCI) to identify cancer‐related family concerns. Then, each member selected one concern to discuss. Immediately after the discussion, participants rated their perception of the discussion and their state positive and negative affect.ResultsParents (mean age = 43.4 years, 56% non‐Hispanic White, two female couples) endorsed high psychological distress, with patients reporting greater family concerns than partners (t = 3.80, p < 0.001). Both members of the couple indicated high levels of self‐disclosure and felt validated and accepted by their partners during the discussion. Yet, patients rated the discussion as more helpful than partners (t = 2.3, p = 0.03). There was a small reduction in positive affect following discussion for partners only. However, the more partners disclosed their emotions, the greater their post‐discussion positive affect (r = 0.50, p < 0.001).ConclusionsCouples' ability to openly communicate around cancer‐related parenting concerns is associated with aspects of psychological adjustment. Findings identify targets and underscore importance of flexibility for future interventions.