bluuebunny/crossref_metadata_2025_split huggingface dataset:
CTSS Modulates Stress-Related Carotid Artery Thrombosis in a Mouse FeCl
3
Model
Authors: Xu Shengnan , Piao Limei , Wan Ying , Huang Zhe , Meng Xiangkun , Inoue Aiko , Wang Hailong , Yue Xueling , Jin Xianglan , Shi Guo-Ping , Kuzuya Masafumi , Cheng Xian Wu 
Published: April 2023

Background:
Exposure to chronic psychological stress is a risk factor for metabolic cardiovascular disease. Given the important role of lysosomal CTSS (cathepsin S) in human pathobiology, we examined the role of CTSS in stress-related thrombosis, focusing on inflammation, oxidative stress, and apoptosis.

Methods:

Six-week-old wild-type mice (CTSS

+/+

) and CTSS-deficient mice (CTSS
−/−
) randomly assigned to nonstress and 2-week immobilization stress groups underwent iron chloride3 (FeCl
3
)-induced carotid thrombosis surgery for morphological and biochemical studies.

Results:

On day 14 poststress/surgery, stress had increased the lengths and weights of thrombi in the CTSS

+/+

mice, plus harmful changes in the levels of PAI-1 (plasminogen activation inhibitor-1), ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 13 motifs), and vWF (von Willebrand factor) and arterial tissue CTSS expression. Compared to the nonstressed CTSS

+/+

mice, the stressed CTSS
−/−
mice had decreased levels of PAI-1, vWF, TNF (tumor necrosis factor)-α, interleukin-1β, toll-like receptor-4, cleaved-caspase 3, cytochrome
c
, p16
INK4A
, gp91
phox
, p22
phox
, ICAM-1 (intercellular adhesion molecule-1), MCP-1 (monocyte chemoattractant protein-1), MyD88 (myeloid differentiation primary response 88), and MMP (matrix metalloproteinase)-2/-9 and increased levels of ADAMTS13, SOD (superoxide dismutase)-1/-2, eNOS (endothelial NO synthase), p-Akt (phospho-protein kinase B), Bcl-2 (B-cell lymphoma-2), p-GSK3α/β (phospho-glycogen synthase kinases alpha and beta), and p-Erk1/2 (phospho-extracellular signal-regulated kinase 1 and 2) mRNAs and/or proteins. CTSS deletion also reduced the arterial thrombus area and endothelial loss. A pharmacological inhibition of CTSS exerted a vasculoprotective action. In vitro, CTSS silencing and overexpression, respectively, reduced and increased the stressed serum and oxidative stress–induced apoptosis of human umbilical vein endothelial cells, and they altered apoptosis-related proteins.

Conclusions:

CTSS inhibition appeared to improve the stress-related thrombosis in mice that underwent FeCl
3
-induction surgery, possibly by reducing vascular inflammation, oxidative stress, and apoptosis. CTSS could thus become a candidate therapeutic target for chronic psychological stress–related thrombotic events in metabolic cardiovascular disease.
Effect of Chronic Digoxin Use on Mortality and Heart Failure Hospitalization in Pulmonary Arterial Hypertension
Authors: Chang Kevin Y. , Giorgio Katherine , Schmitz Katlin , Walker Rob F. , Prins Kurt W. , Pritzker Marc R. , Archer Stephen L. , Lutsey Pamela L. , Thenappan Thenappan 
Published: April 2023

Background
Digoxin acutely increases cardiac output in patients with pulmonary arterial hypertension (PAH) and right ventricular failure; however, the effects of chronic digoxin use in PAH are unclear.

Methods and Results
Data from the Minnesota Pulmonary Hypertension Repository were used. The primary analysis used likelihood of digoxin prescription. The primary end point was a composite of all‐cause mortality or heart failure (HF) hospitalization. Secondary end points included all‐cause mortality, HF hospitalization, and transplant‐free survival. Multivariable Cox proportional hazards analyses determined the hazard ratios (HR) and 95% CIs for the primary and secondary end points. Among 205 patients with PAH in the repository, 32.7% (n=67) were on digoxin. Digoxin was more often prescribed to patients with severe PAH and right ventricular failure. After propensity score‐matching, 49 patients were digoxin users, and 70 patients were nonusers; of these 31 (63.3%) in the digoxin group and 41 (58.6%) in nondigoxin group met the primary end point during a median follow‐up time of 2.1 (0.6–5.0) years. Digoxin users had a higher combined all‐cause mortality or HF hospitalization (HR, 1.82 [95% CI, 1.11–2.99]), all‐cause mortality (HR, 1.92 [95% CI, 1.06–3.49]), HF hospitalization (HR, 1.89 [95% CI, 1.07–3.35]), and worse transplant‐free survival (HR, 2.00 [95% CI, 1.12–3.58]) even after adjusting for patient characteristics and severity of PAH and right ventricular failure.

Conclusions
In this retrospective, nonrandomized cohort, digoxin treatment was associated with greater all‐cause mortality and HF hospitalization, even after multivariate correction. Future randomized controlled trials should assess the safety and efficacy of chronic digoxin use in PAH.
Incident Atrial Fibrillation and Risk of Dementia in a Diverse, Community‐Based Population
Authors: Bansal Nisha , Zelnick Leila R. , An Jaejin , Harrison Teresa N. , Lee Ming‐Sum , Singer Daniel E. , Fan Dongjie , Go Alan S. 
Published: April 2023

Background
Atrial fibrillation (AF) is the most common, clinically relevant arrhythmia in adults and associated with ischemic stroke and premature death. However, data are conflicting on whether AF is independently associated with risk of dementia, particularly in diverse populations.

Methods and Results

We identified all adults from 2 large integrated health care delivery systems between 2010 and 2017 and performed a 1:1 match of incident AF: no AF by age at index date, sex, estimated glomerular filtration rate category, and study site. Subsequent dementia was identified through previously validated diagnosis codes. Fine‐Gray subdistribution hazard models were used to examine the association of incident AF (versus no AF) with risk of incident dementia, adjusting for sociodemographics and comorbidity and accounting for competing risk of death. Subgroup analyses by age, sex, race, ethnicity, and chronic kidney disease status were also performed. Among 196 968 matched adults, mean (SD) age was 73.6 (11.3) years, with 44.8% women, and 72.3% White. Incidence rates (per 100 person‐years) for dementia over a median follow‐up of 3.3 (interquartile range, 1.7–5.4) years were 2.79 (95% CI, 2.72–2.85) and 2.04 (95% CI, 1.99–2.08) per 100 person‐years in persons with versus without incident AF, respectively. In adjusted models, incident AF was associated with a significantly greater risk of diagnosed dementia (subdistribution hazard ratio [sHR], 1.13 [95% CI, 1.09–1.16]). With additional adjustment for interim stroke events, the association of incident AF with dementia remained statistically significant (sHR, 1.10 [95% CI, 1.07–1.15]). Associations were stronger for age <65 (sHR, 1.65 [95% CI, 1.29–2.12]) versus ≥65 (sHR, 1.07 [95% CI, 1.03–1.10]) years (interaction
P
<0.001); and those without (sHR, 1.20 [95% CI, 1.14–1.26]) versus with chronic kidney disease (sHR, 1.06 [95% CI, 1.01–1.11]; interaction
P
<0.001). No meaningful differences were seen by sex, race, or ethnicity.

Conclusions
In a large, diverse community‐based cohort, incident AF was associated with a modestly increased risk of dementia that was more prominent in younger patients and those without chronic kidney disease but did not substantially vary across sex, race, or ethnicity. Further studies should delineate mechanisms underpinning these findings, which may inform use of AF therapies.
RCMR 280k: Refined Corpus for Move Recognition Based on PubMed Abstracts
Authors: Li Jie , Yu Gaihong , Zhang Zhixiong 
Published: April 2023

ABSTRACT
Existing datasets for move recognition, such as PubMed 200k RCT, exhibit several problems that significantly impact recognition performance, especially for Background and Objective labels. In order to improve the move recognition performance, we introduce a method and construct a refined corpus based on PubMed, named RCMR 280k. This corpus comprises approximately 280,000 structured abstracts, totaling 3,386,008 sentences, each sentence is labeled with one of five categories: Background, Objective, Method, Result, or Conclusion. We also construct a subset of RCMR, named RCMR_RCT, corresponding to medical subdomain of RCTs. We conduct comparison experiments using our RCMR, RCMR_RCT with PubMed 380k and PubMed 200k RCT, respectively. The best results, obtained using the MSMBERT model, show that: (1) our RCMR outperforms PubMed 380k by 0.82%, while our RCMR_RCT outperforms PubMed 200k RCT by 9.35%; (2) compared with PubMed 380k, our corpus achieve better improvement on the Results and Conclusions categories, with average F1 performance improves 1% and 0.82%, respectively; (3) compared with PubMed 200k RCT, our corpus significantly improves the performance in the Background and Objective categories, with average F1 scores improves 28.31% and 37.22%, respectively. To the best of our knowledge, our RCMR is among the rarely high-quality, resource-rich refined PubMed corpora available. Our work in this paper has been applied in the SciAIEngine, which is openly accessible for researchers to conduct move recognition task.
Built Offering: On the Conception and Design of the Greek Temple
Authors: Wilson Jones Mark 
Published: April 2023

Abstract
The form of the Greek temple responded to multiple purposes, influences and concepts, although one of these, that of offering, deserves more attention than it has received to date. The fundamental status of offering for Greek religion and its societal expression resulted in sanctuaries being choc-a-bloc with all manner of dedications, some of which represented the finest displays of artistic merit, workmanship, materials and cost that could be afforded. Indeed, as is well known, much of the Greek art on view in modern museums originally had the status of offerings made for dedication in sanctuaries. While it is true that some scholars of religion have noted that temples too were offerings, amongst other things, the implications have generally gone unnoticed. After reviewing the various functions of temples, this essay identifies nuances of offering in their plan, size, elevation, architectural elements, ornamentation and quality. This helps us to appreciate temples as cultural manifestations akin to everything else in the sanctuaries. As works of architecture the form of the Greeks’ temples responded to multiple issues (construction, precedent, influences and so on), but now we can see how their visual treatment subtly and yet eloquently reflected their very nature.
Possible Syrian Influences on the Emergence of the Greek Monumental Temple
Authors: Kaasgaard Falb Ditte Zink 
Published: April 2023

Abstract
In this article, the Greek temple is set into a larger historical and cultural context, comparing it with Near Eastern and especially Syrian temples. The author argues that the Syrian temple in antis played a significant role in the development of the Greek prostyle temple. This is demonstrated by briefly highlighting the mostly overlooked aspects of Oriental or Syrian building traditions, which, in addition to other traditions in the Mediterranean, could have played an influential role in the conception of the Greek temple cella.
Temple Landscape: The Direct and the Latent Impact of Natural Environment upon Artificial Environs
Authors: Partida Elena C. 
Published: April 2023

Abstract
The dynamics of an ancient religious centre lies in the combination of architecture with the geophysical relief and natural setting, namely the manner in which a temple befits its natural surroundings. Paintings and etchings/lithographs help us follow the transformation of hieratic settings in the course of centuries. An intriguing juxtaposition is that of tree cult to the practical role of timber in ancient worksites, as revealed through building accounts and classical authors. Turning to ritual symbolism, we see vegetation lending its forms to works of sculpture. Yet, most impressive is the infiltration of tree prototypes and floral patterns in architecture, affecting not only decorative styles and orders but also the morphology of structural elements. The article’s last section involves landscape restoration/re-creation attempted by the replanting of ancient species. This was based on either ancient literary and epigraphic sources or laboratory analyses, namely botanical and pollen research. The results of these methods, however, do not always converge.
Euripides on the Ancient Cult of Apollo at Athens
Authors: Saporiti Marta 
Published: April 2023

Abstract
This paper uses the tragedies of Euripides as evidence for a reconsideration of the topography of the Athenian cults of Apollo, particularly Apollo Pythios, Hypoakraios, and Delphinios. Euripides’ references to these cults are generally well known among topographers of Athens, but they are typically considered only as disembodied quotations. However, reading and analysing the literary sources more deeply as unitary wholes can enrich and complicate the traditional debates about the topography of these cults.
The Religious Taxonomy of Attic Associations
Authors: Ammitzbøll Thomsen Christian 
Published: April 2023

Abstract
Judging from the epigraphic record, the first through third centuries BCE saw the rise of a large number of private cult associations throughout the Greek-speaking world. This was particularly true of Athens. Some associations, however, were more devout than others, at least according to modern historians who have seen in associations of eranistai groups of “venture capitalists” operating under a religious pretext. This paper challenges the traditional taxonomy of cult associations by way of a re-examination of the literary and epigraphic evidence and a comparison between eranistai and other cult associations, primarily thiasōtai and orgeōnes, with a specific focus on various aspects of organisation, membership, and activities in Hellenistic Athens.
The Great Goddess of Anatolia and her Greek Daughters: Late Bronze Age Origins in Rituals, Architecture, and Iconography
Authors: Carstens Anne Marie 
Published: April 2023

Abstract
This contribution focuses on the materialization of cults of the Anatolian goddess in her various guises. It offers a preliminary investigation of Late Bronze Age roots of later ritual practice in the major sanctuaries of the great goddess of western Anatolia and the Aegean Islands. Thus, it is an exploration of what Walter Burkert has called “eastern contexts of Greek culture, and Greek contexts of Anatolian culture”- in essence, a field study of the nature and transmission of cult tradition and the conservative power of ritual.
Predictive Factors for Mortality Following Major Lower Extremity Amputation
Authors: Morton Claire , Rolle Nicholas , Shalini Sahoo  , Kaufman Miriam , Drucker Charles , Nagarsheth Khanjan 
Published: April 2023

Background Despite advances in techniques and care, major amputation bears a high risk for mortality. Previously identified factors associated with increased risk of mortality include amputation level, renal function, and pre-operative white cell count. Methods A single center retrospective chart review was conducted identifying patients who had undergone a major amputation. Chi-squared, t-testing, and Cox proportional hazard modeling were performed examining death at 6 months and 12 months. Results Factors associated with an increased risk of six-month mortality include age (OR 1.01-1.05, P < .001), sex (OR 1.08-3.24, P < .01), minority race (OR 1.18-18.19, P < .01), chronic kidney disease (OR 1.40-6.06, P < .001), and use of pressors at the induction of anesthesia for index amputation (OR 2.09-7.85, P < .000). Factors associated with increased risk of 12 month mortality were similar. Discussion Patients undergoing major amputation continue to suffer high mortality. Those patients who received their amputation under physiologically stressful conditions were more likely to die within 6 months. Reliably predicting six-month mortality can assist surgeons and patients in making appropriate care decisions.
Safety of the Trauma Quality Improvement Program Guideline for Venous Thromboembolism Prophylaxis in Traumatic Brain Injury
Authors: Ferenczy Allison M. , Strawn Daniel , Strawn Daniel , Johns Tracy , Parel Robert J. , Ashley Dennis W. 
Published: April 2023

Background The American College of Surgeons (ACS) Trauma Quality Improvement Program (TQIP) provides a guideline for when to initiate pharmacologic venous thromboembolism (VTE) prophylaxis in traumatic brain injury (TBI) patients. We hypothesized that implementation of the guideline would not result in progression in intracranial hemorrhage. Methods The TBI TQIP guideline was implemented at a Level I Trauma Center. Patients with a stable Computerized tomography (CT) of the brain were started on chemical prophylaxis per the Modified Berne-Norwood Criteria. CT scans before and after initiation of treatment were retrospectively reviewed by one board-certified radiologist to determine if there was progression of hemorrhage. Patients without a follow-up CT scan were evaluated for progression of bleed/neurologic deterioration by review of physician notes, nursing documentation, and Glasgow coma scale (GCS). Results From July 2017 to December 2020, 12,922 patients were admitted to the trauma service. A total of 552 of these patients had TBI and 269 met inclusion criteria. 55 patients had at least one CT of the brain after initiation of prophylaxis. None of these 55 patients had progression of hemorrhage. 214 patients did not have a CT of the brain after prophylaxis. Chart review showed that none of these patients had a clinical decline. Overall, there was no progression of hemorrhage in the 269 patients that met inclusion criteria. Discussion Initiation of the TQIP TBI VTE prophylaxis guideline was found to be safe with no progression of intracranial hemorrhage.
Influence of acid concentration on thermomechanical, tensile and thermal properties of cyclized natural rubber
Authors: Jaratrotkamjorn Ruedee , Hayeemasae Nabil , Zakaria Zunaida , Masa Abdulhakim 
Published: April 2023

Properties of cyclized natural rubbers (NR) with various degrees of cyclization (∼4-22%) were investigated in this study. Prior to compounding with rubber additives, the cyclized rubbers were initially prepared by dropping various concentrations of acid (5-30 wt%) to the NR latex, followed by coagulation and drying. The results revealed that the degree of cyclization increased with acid concentration. Increased ring structure formation in the modified NR tended to increase the torque difference during crosslinking, as the cyclic ring structures acted as steric hindrances. The crosslink density was found to decrease with increasing cyclization level due to the loss of active sites for crosslink formation, increasing swelling capability of the cyclized rubbers. The 100% and 300% moduli, tensile strength and extensibility of the NR reduced with increasing degree of cyclization due to a reduction of crosslink density. As a result of cyclic structure formation and a reduction of unsaturated double bonds in the NR, the stability of cyclized NR at elevated temperatures was improved over the pure NR, in a manner dependent on the level of cyclization. Single glass transition temperature was seen in the NR while two glass transition temperatures were noticed in the cyclized NR. The thermal stability of 22% cyclized NR was 50°C higher than that of the pure NR and the aging properties of the cyclized NRs were also greater mainly due to a reduction of unsaturated double bonds. This suggests that cyclized NR may find applications in products requiring thermal resistance.
MRI Does Not Improve Inter- or Intrarater Reliability for Hip Arthritis Grading Systems
Authors: Pullen W. Michael , Pierre Kinsley , Wong Ivan , Aoki Stephen K. , Lynch T. Sean , Mather Richard C. , Ayeni Olufemi R. , Byrd J.W. Thomas , Safran Marc R. 
Published: April 2023

Background: Magnetic resonance imaging (MRI) scans and radiographs are often utilized in assessing for preoperative osteoarthritis in patients undergoing hip preservation surgery. Purpose: To determine if MRI scans improve inter- or intrarater reliabilities over radiographs for findings of hip arthritis. Study Design: Cohort study (Diagnosis); Level of evidence, 3. Methods: Anteroposterior and cross-table lateral radiographs as well as a representative coronal and sagittal T2-weighted MRI scan were reviewed for 50 patients by 7 experienced subspecialty hip preservation surgeons, with a minimum experience of 10 years. Radiographs and MRI scans were assessed for joint space narrowing, subchondral cysts, osteophytes, subchondral sclerosis, Likert osteoarthritis grade (none, mild, moderate, or severe), and Tönnis grade. MRI scans were also evaluated for bony edema, heterogeneous articular cartilage, and chondral defects. Inter- and intrarater reliabilities were calculated utilizing the Fleiss method with a 95% CI. Results: The scans of 50 patients (28 female and 22 male) with a mean age of 42.8 years (SD, 14.2 years; range, 19-70 years) were reviewed. Radiographs revealed fair agreement for joint space narrowing (κ = 0.25 [95% CI, 0.21-0.30]), osteophytes (κ = 0.26 [95% CI, 0.14-0.40]), Likert osteoarthritis grading (κ = 0.33 [95% CI, 0.28-0.37]) and Tönnis grade (κ = 0.30 [95% CI, 0.26-0.34). Radiographs revealed moderate agreement for subchondral cysts (κ = 0.53 [95% CI, 0.35-0.69]). MRI scans demonstrated poor to fair agreement for joint space narrowing (κ = 0.15 [95% CI, 0.09-0.21]), subchondral sclerosis (κ = 0.27 [0.19-0.34]), heterogeneous articular cartilage (κ = 0.07 [95% CI, 0.00-0.14]), Likert osteoarthritis grade (κ = 0.19 [95% CI, 0.15-0.24]), and Tönnis grade (κ = 0.20 [95% CI, 0.15-0.24]). MRI scans demonstrated substantial agreement for subchondral cysts (κ = 0.73 [95% CI, 0.63-0.83]). Intrarater reliabilities were statistically improved compared with interrater reliabilities, but no differences were found between radiographs and MRI scans for joint space narrowing, subchondral cysts, osteophytes, osteoarthritis grade, or Tönnis grade. Conclusion: Radiographs and MRI scans had substantial limitations and inconsistency between raters in evaluating common markers of hip osteoarthritis. MRI scans demonstrated strong reliability in evaluating for subchondral cysts but did not improve the interobserver variability of grading hip arthritis.
Consumer? Views and preferences of people receiving public mental health care in Australia on the terms used to refer to them
Authors: Lugg William , Levine Andrew , Boyd Robert 
Published: April 2023

Objectives To understand: a) whether adults receiving public mental health care were aware they were officially referred to as ‘consumers’ and, b) their views and preferences on the terms used to refer to them. Methods Single-page, anonymous survey conducted across two community mental health services in Northern New South Wales (NNSW). Ethics approval obtained from the local research office. Results 108 people completed the survey with a response rate of approximately 22%. The vast majority (77%) of respondents were not aware that they were officially referred to as ‘consumers’. 32% of respondents disliked the term ‘consumer’ and 11% found it offensive. Half preferred the term ‘patient’, particularly when consulting a psychiatrist (55%). A small minority (5–7%) preferred the term ‘consumer’ for any care interaction. Conclusion Most respondents in this survey wished to be referred to as a ‘patient’ and a large proportion disliked being referred to as a ‘consumer’ or found it offensive. Further surveys should include broader sociodemographic and diagnostic/treatment variables. Official terms used to refer to people receiving public mental health care should be person-centred and evidence based.