bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining Knowledge and Opinions of Neonatal Intensive Care Unit Nurses on Wet-Nursing and Human Milk Banks: A Cross-Sectional Study in Türkiye
Authors: Konukbay Dilek , Kapan Emine , Yildiz Dilek 
Published: September 2023

Background: Wet nursing and human milk banks are vital sources of human milk for infants unable to breastfeed. Research Aim: This study aims to determine the knowledge and opinions of neonatal intensive care unit nurses regarding wet-nursing and human milk banks in Türkiye. Methods: This descriptive cross-sectional study was conducted with 219 neonatal intensive care unit nurses using an online survey comprising 20 questions. The data were collected between August and September 2021. Results: Among the participants, 64.4% ( n = 141) expressed that they would be a wet-nurse and 59.8% ( n = 131) would search for a wet-nurse if necessary. Some, 47.0% ( n = 103) of participants did not know if there were any human milk banks in Türkiye, 53.9% ( n = 118) would like to be a donor if human milk banks were established, and 71.7% ( n = 157) stated that the establishment of human milk banks should be supported. Religious concerns were the basis for reluctance to donate milk to human milk banks for 60% ( n = 51) of the participants. Knowledge was greater and opinions about wet-nursing and human milk banks were more positive for participants with higher education, more time in the neonatal intensive care unit, or work at a tertiary care center. Conclusion: The approaches of neonatal intensive care unit nurses towards personally being wet-nurses and milk sharing were generally positive, although more information about human milk banks is needed. Religious beliefs are an important consideration when providing information about milk sharing.
Preparation of multifunctional flame-retardant coating of cotton fabrics for electrical Insulating applications
Authors: Abdelkhalik Aksam , Makhlouf Ghada , Ameen Heba , El-Gamal Abear Abdullah 
Published: September 2023

Cotton fabric (CF) was coated with a new multifunctional flame-retardant system consisting of melamine phosphate (MP) and nickel (II) dimethylglyoxime (NDMG). The new coating was applied to enhance the flame retardancy, antibacterial activity, thermal stability, color strength, UV protection, and electrical properties of CF. The weight percentages of NDMG and MP that led to the maximum improvement in CF properties were identified. According to vertical and horizontal flammability tests, coating the fabric with 29%MP/1%NDMG prevented flame propagation in the samples. Moreover, it increased the limiting oxygen index (LOI) of CF from 17.9% to 36.9%. Thermogravimetric analysis (TGA) data presented that the MP/NDMG coating enhanced the char residue at 750°C. Antimicrobial investigations indicated that the coating 29%MP/1%NDMG reduced the growth of S. aureus and E. coli bacteria. UV shielding and color strength (K/S) results revealed that coated fabrics had excellent UV protection (UPF > 175) and enhanced K/S values. The tensile strength of CF was slightly decreased after the coating process. The dielectric constant (ε`), the dielectric loss (ε``), and AC electrical resistivity ([Formula: see text]) with frequency (10-106 Hz) were also investigated. The electrical resistivity increased significantly after adding MP and NDMG to the CFs. The coated sample (23%MP/7%NDMG) showed the best dielectric properties, with a low dielectric constant of 2.6 and [Formula: see text] of 1.40E+10 Ω.cm at 1000 Hz.
Weight gain and metabolic disturbances in people living with HIV who start antiretroviral therapy with, or switch to, bictegravir/emtricitabine/tenofovir alafenamide after 48 weeks of treatment: A real-world prospective study
Authors: Mata Marín José Antonio , Velasco-Penagos Juan Carlos , Mauss Stefan , Rodriguez-Evaristo Mara Soraya , Pérez-Barragán Edgar , Villa-Platas Joaquín , Barragán-Huerta Laura , Gaytán-Martínez Jesús Enrique 
Published: September 2023

Background People living with HIV (PLWH) starting or switching to an integrase strand transfer inhibitor-based regimen are more likely to experience weight gain than other classes of antiretroviral regimens. The aim of this study was to evaluate the weight gain and metabolic disturbances in PLWH who start antiretroviral therapy (ART) with bictegravir/emtricitabine/tenofovir alafenamide and in individuals who switch from another ART to BIC/FTC/TAF after 48 weeks. Methods A prospective longitudinal study was conducted in an HIV clinic in Mexico. Weight and metabolic parameters were measured at baseline, 24 and 48 weeks. A paired t test and Wilcoxon signed-rank test were applied to evaluate weight and metabolic changes. Results 160 participants completed measurements, median age was 29 (IQR 26-32) and 30 (IQR 27–34) years old for the treatment-naïve and switch group respectively. In the treatment-naïve group, mean weight change was 3.8 kg (±5.8) ( p < .001) and BMI increased 1.3 kg/m2 (±2) ( p < .001) at 48 weeks. Incidence of BMI >25 kg/m2 was 28% (95%CI; 18%–40%) and BMI >30 kg/m2 was 7% (95%CI; 2%–16%) at 48 weeks in treatment-naïve individuals. In the switch group, mean weight gain and BMI change at 48 weeks was 2.8 kg (±5.9) and 0.9 kg/m2 (±2.0) respectively ( p < .001). Incidence of BMI >25 kg/m2 was 17% (95%CI; 8%–32%) and BMI >30 kg/m2 12.8% (95%CI; 5%–26%) at 48 weeks respectively. Conclusions Weight gain should be considered when men PLWH are treated with BIC/FTC/TAF regimen. They should be informed about this possible adverse event and strategies of intervention.
Accuracy of a Patient-Specific Total Ankle Arthroplasty Instrumentation
Authors: April Pierre-Marc , Locke Eric , Champagne Philippe-Hugo , Angers Magalie , Martinez-Gomez Adriana Patricia , Seidel Angela , Jibri Zaid , Lalonde Karl-Andre , Meulenkamp Brad 
Published: September 2023

Background: Total ankle arthroplasty (TAA) is a preferred surgical option for end-stage ankle osteoarthritis; however, it is a demanding procedure with a higher historical rate of revision compared with ankle fusion. Patient-specific instrumentation (PSI) has been introduced to optimize prosthesis alignment and theoretically overall improve TAA outcomes. The goal of this study is to report on the experience and surgical outcomes of one implant with specific evaluation of the accuracy and reproducibility of the system with respect to prosthesis alignment and prediction of implant size. Methods: A retrospective, multicentered study involving 4 foot and ankle fellowship–trained orthopaedic surgeon’s patients undergoing TAA between January 1, 2015, and December 31, 2018, using the PROPHECY PSI system. Results: 80 TAA procedures were performed. On average the postoperative tibial component alignment was 89.9 (range, 86.1-96.5) degrees in the coronal plane, with a mean sagittal alignment of 88.1 (range, 81.3-96.7) degrees. The mean deviation from neutral sagittal alignment improved from 4.9 ± 3.9 degrees preoperatively to 2.7 ± 1.7 degrees postoperatively, whereas the mean coronal alignment improved from 3.3 ± 2.5 degrees to 1.3 ± 1.1 degrees. The PSI software correctly determined the tibial implant size in 70 patients (89%). Prediction of talar implant sizing was less accurate than the tibial component, with 56 patients (71%) using the predicted sized implant. The overall implant survival at a mean follow-up of 45 months (range, 27-76) was 97.5%. Conclusion: We found that this PSI system accurately and reliably assisted in implant total ankle prosthesis positioning within a clinically acceptable margin and without significant outliers. Prediction of implant size was not as accurate as component orientation. Level of Evidence: Level III, retrospective study.
Cancer Screening Rates Among Asian Americans: A Cross-Sectional Secondary Data Analysis Study
Authors: Lei Fang , Lee Eunice 
Published: September 2023

Purpose This study aims 1) to investigate recent cancer screening rates among Asian Americans and 2) to test the relationship between race/ethnicity and cancer screening rates. Methods This is a cross-sectional secondary data analysis study using data from the 2019 National Health Interview Survey. The screening rates of prostate cancer, colorectal cancer, cervical cancer, and breast cancer among non-Hispanic (NH) Asian Americans, Hispanics, NH Whites, NH African Americans, and NH American Indian and Alaska Natives (AIAN) were analyzed in July 2022. The variables were recoded and analyzed using descriptive analysis and chi-square test. The SPSS version 27 software was used. Results Descriptive analysis showed a general low screening rate of cancers among Asian Americans, which ranged from 40.5% to 67.5%. The chi-square test suggested significant associations between race/ethnicity and the screening rates of colorectal cancer ( P = .002), cervical cancer ( P < .01), and breast cancer ( P = .021), but not the prostate cancer ( P = .472). Conclusion Necessary intervention programs should be designed to increase the uptake rates of cancer screening among Asian Americans.
Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients
Authors: Zhang Jiaqi , Yin Xin , Wang Hao , Fang Tianyi , Gao Jialiang , Zhu Ziyu , Li Chunfeng , Wang Yufei , Wang Xibo , Lu Zhanfei , Wu Junpeng , Wang Yimin , Zhang Yao , Xue Yingwei 
Published: September 2023

Background Tumor markers (TMs) are important for the prognosis of gastric cancer (GC). However, the prognostic importance of the tumor marker index (TMI) based on GC-specific TMs for advanced gastric cancer (AGC) still needs to be further explored. Methods We retrospectively examined patients who underwent radical gastric cancer surgery between February 2014 and June 2016 at the Department of Gastroenterological Surgery, Affiliated Cancer Hospital, Harbin Medical University. The patients were divided into training and validation groups. TMI was determined as the geometric mean of the standard cancer antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) levels. Patient overall survival was assessed using the Kaplan–Meier method. Independent prognosis-associated risk factors were identified using Cox hazard regression models. A nomogram model incorporating TMI and clinicopathological factors was developed, and its performance was evaluated using a decision curve analysis, concordance index, and calibration plots. Results In the TMI training cohort, the cutoff value was set at .439, categorizing patients into TMI-High and TMI-Low groups. The 5-year survival rate in the TMI-Low group significantly surpassed that in the TMI-High group (78.2% vs 58.1% and 49.7 vs 41.6, P < .001). TMI emerged as an independent prognostic factor. The nomogram accurately predicted patient prognosis by using TMI and clinicopathological characteristics. Validation of the TMI in the independent cohort yielded satisfactory results. Conclusion The TMI constructed based on specific TMs associated with gastric cancer can offer a precise prognostic prediction for patients.
Differential Diagnostic Value of Machine Learning–Based Models for Embolic Stroke
Authors: Kuo HsunYu , Liu Tsai-Wei , Huang Yo-Ping , Chin Shy-Chyi , Ro Long-Sun , Kuo Hung-Chou 
Published: September 2023

Cancer-associated thrombosis (CAT) and atrial fibrillation (AF)-related stroke are two subtypes of acute embolic stroke with distinct lesion patterns on diffusion weighted imaging (DWI). This pilot study aimed to evaluate the feasibility and performance of DWI-based machine learning models for differentiating between CAT and AF-related stroke. Patients with CAT and AF-related stroke were enrolled. In this pilot study with a small sample size, DWI images were augmented by flipping and/or contrast shifting to build convolutional neural network (CNN) predicative models. DWI images from 29 patients, including 9 patients with CAT and 20 with AF-related stroke, were analyzed. Training and testing accuracies of the DWI-based CNN model were 87.1% and 78.6%, respectively. Training and testing accuracies were 95.2% and 85.7%, respectively, for the second CNN model that combined DWI images with demographic/clinical characteristics. There were no significant differences in sensitivity, specificity, accuracy, and AUC between two CNN models (all P = n.s.). The DWI-based CNN model using data augmentation may be useful for differentiating CAT from AF-related stroke.
Evaluating cost savings in cytotoxic leftover management: A prospective study of vial sharing and dose rounding techniques in the Moroccan National Institute of Oncology
Authors: El Baraka Soumaya , Cherif Chefchaouni Ali , Bourdaime Aya , Ouedraogo Jean-Marie , Shytry Oumaima , Belahcen Mohammed-Jaouad , Rahali Younes 
Published: September 2023

Objective Most intravenous anticancer drugs are administered in a dose per unit area or body weight, if not promptly administered to another patient cytotoxic leftover would be destroyed. To contain wastage, low-cost measures are highly desirable to contain and reduce expenditures without impairing the quality of care. The objective of the study is to evaluate the cost saved through the use of the two cytotoxic waste management techniques implemented in National Institute of Oncology’s centralized chemotherapy preparation unit, vial sharing and dose rounding. Method A 6-month prospective single centre study from 1 February to 1 August 2023 at the National Institute of Oncology of Rabat in Morocco. The number of prepared preparations and amount of drug saved by both vial sharing and dose rounding was collected using the centralized chemotherapy preparation unit’s ‘leftover tracking file’, the corresponding cost saved were calculated and then compared for each technique and with 2018 results. Results In total, 18,218 preparations were considered in the 6-month study. With the vial sharing technique 636,524.5 mg were saved corresponding to 246,031.4 (USD) saved cost, against 212,838.4 mg by dose rounding corresponding to 75,598.5 (USD) saved cost. This saving corresponded to a total of 321,629.4 (USD). Compared to the 2018 results leftovers costs saved by vial sharing corresponded to 289,972.05 (USD) by vial sharing technique for 1-year extrapolated period, and this study shows a saved cost of 321,629.9 (USD) by both vial sharing and dose rounding techniques. Conclusion Dose rounding technique combined with vial sharing allowed National Institute of Oncology’s centralized chemotherapy preparation unit to limit expensive cytotoxic cost wastage, highlighting these technique benefits.
Clinical characteristics and long-term outcomes of septic arthritis of the native hip joint: a 20-year retrospective review
Authors: Burdick Gabriel B , Maier Lindsay M , Kuhlmann Noah A , Ayoola Ayooluwa S , Fathima Bushra , Muh Stephanie J 
Published: September 2023

Background: The primary purpose of this retrospective case series was to describe the prevalence and outcomes of single-stage hip arthroplasty in patients who were previously treated for septic arthritis of the native hip at our institution over a 20-year period. This study also examined rates of persistent or recurrent infection, reoperation, and mortality for septic arthritis of the native hip. Methods: Adult patients treated for septic arthritis of the native hip at our institution from 1995 to 2015 were retrospectively identified. Exclusion criteria included age <18 years, missing or incomplete medical records, treatment at an outside institution, and prior surgery of the hip. Results: 97 patients were included in this study. 3 patients (3.1%) who were previously treated for septic arthritis of the native hip underwent single-stage hip arthroplasty an average of 40 ± 25 months from the date of infection. 3 of the 18 (16.7%) patients who were treated with resection arthroplasty underwent second-stage joint reconstruction. There were no cases of periprosthetic joint infection (PJI). 1 patient who underwent single-stage arthroplasty experienced implant-induced metallosis, necessitating removal of the implant. There were no other cases of revision arthroplasty. Conclusions: The prevalence of single-stage hip arthroplasty in patients with a history of septic arthritis of the native hip joint was 3.1%, which is higher than the prevalence of hip arthroplasty in the United States general population, suggesting that a history of septic arthritis may increase the risk of requiring hip arthroplasty. In the small number of patients who went on to receive a hip replacement, there were no reported cases of PJI. This study suggests that hip arthroplasty is a viable option for patients with symptomatic osteoarthritis and a history of septic arthritis of their hip.
Directional Atherectomy With Antirestenotic Therapy Versus PTA/Supera Stenting for Popliteal Artery Lesions: A Propensity-Matched Analysis
Authors: San Norberto Enrique M. , Revilla Álvaro , Brizuela José Antonio , Díez Manuel , Taylor James H. , Riera del Moral Luis F. 
Published: September 2023

Purpose: This study examines the use and impact of directional atherectomy with antirestenotic therapy (DAART) versus angioplasty plus Supera stent implantation on the outcomes during endovascular treatment of popliteal lesions in clinical practice. Methods: Overall 143 consecutive patients (mean age 75.0±12.2 years, 72% male), with isolated atherosclerotic disease of the popliteal artery who underwent endovascular treatment using DAART therapy or percutaneous transluminal angioplasty (PTA)/Supera stenting of the popliteal artery between January 2016 and December 2021 were identified from a retrospectively database. Patient and plaque characteristics were collected. A propensity-score matched, case-control analysis was conducted to balance covariates between the group of patients who underwent DAART and the one treated by PTA/Supera stenting. Results: A total of 51 patients (35.7%) showed severe claudication and 92 (64.3%) critical limb ischemia. There was a trend toward longer treated lesions (90.4±81 vs 72.5±5.3 mm, p=0.089) and more chronic total occlusions (60.5% vs 46.8%, p=0.058) in the PTA/Supera stenting group, although not reaching statistically significance. Moderate-to-severe calcification was present in most lesions treated (75.8% of DAART group, 80.2% of PTA/Supera stenting group, and 78.3% of total cohort). Among the 53 case-matched pairs of patients treated with DAART or PTA/Supera stenting, there were no significant differences in short-term outcomes, including rate of technical success (96.2% vs 98.1%, p=0.232), procedural success (88.7% vs 90.1%, p=0.251), distal embolization (1.9% vs 1.9%, p=0.178), dissection (5.7% vs 1.9%, p=0.268), perforation (3.8% vs 5.6%, p=0.163), hospital discharge (1.2±0.1 vs 1.0±0.1, p=0.325), 30 day minor (28.3% vs 32.1%, p=0.264) or major amputation rates (7.5% vs 3.8%, p=0.107), and 30 day mortality (1.9% vs 1.9%, p=0.173). At 1 year, there was no difference in primary patency (73.6% vs 77.4%, p=0.233), primary assisted patency (81.3% vs 84.9%, p=0.167), secondary patency (86.8% vs 92.5%, p=0.094), ipsilateral minor (35.8% vs 39.6%, p=0.472) or major amputation (9.4% vs 7.5%, p=0.186), ankle brachial index improvement (0.32±0.12 vs 0.37±0.37, p=0.401), or mortality (5.7% vs 5.7%, p=0.121) rate between patients who underwent DAART or PTA/Supera stenting for popliteal lesions. Conclusion: Twelve-month results following DAART technique or PTA/Supera stenting of atherosclerotic lesions of the popliteal artery are not different, regardless of patient and plaque characteristics. Clinical Impact The DAART technique for the treatment of popliteal artery atherosclerotic disease is presented as a “leave nothing behind” strategy with on-year clinical outcomes similar to ATP/Supera stenting.
The Role of Location, Length, and Thickness of the Intimal Flap in the Propagation of Stanford Type B Aortic Dissection Based on Ex Vivo Porcine Aorta Models
Authors: Wang Shuangjing , Jia Heyue , Xi Yifu , Yuan Pengfei , Wu Mingwei , Guo Wei , Chen Duanduan , Xiong Jiang 
Published: September 2023

Purpose: To explore the role of location, length, and thickness of the intimal flap in the propagation of Stanford type B aortic dissection (TBAD) based on ex vivo porcine aorta models based on ex vivo porcine aorta models. Materials and Methods: The porcine aortas were harvested and randomly divided into 6 groups to create various TBAD aortic models. We constructed intimal flaps for different locations (group A [entry tear on outer curvature] and group B [entry tear on inner curvature]), lengths (group C [long] and group D [short]), and thicknesses (group E [thick] and group F [thin]). For the ex vivo perfusion experiments conducted on model aortas, an experimental circulation loop (ECL) was employed. The pressure in false lumen (FL) was constantly monitored. A comparison was made between the morphological data collected before and after the experiment to quantify the changes in the FL after the experiment. Results: Compared the results with group B, the mean peak pressures of the FL in group A were lower (106.87±15.55 vs. 124.01±22.75 mm Hg, p=0.028). The mean axial propagation length in group A was shown to be shorter than that of group B (88.14±33.38 vs. 197.43±41.65 mm, p<0.001). The mean peak pressure was higher in group C than in group D (144.04±19.37 vs. 92.51±26.70 mm Hg, p<0.001). The mean peak pressure of group E was higher than that of group F (160.83±32.83 vs. 109.33±15.62 mm Hg, p<0.001), as was the mean axial propagation length of group E (143.11±39.73 vs. 100.45±35.44 mm, p=0.021). According to the results of multivariable linear regression, axial propagation length=45.873–0.703×length of initial FL+0.863× peak pressure (p<0.001). Conclusion: There was a relationship between FL propagation and the location, length, and thickness of the intimal flap. The axial propagation length was related to the length of the intimal flap and the peak pressure of propagation. It may be helpful to evaluate the risk of propagation in patients with TBAD. Clinical Impact This study found that the locations, lengths, and thickness of the intimal flap significantly contributed to propagation pressure of FL. Using dissection flap characteristics, a physician can predict FL development in a patient and formulate a treatment plan.The purpose was to investigate the relationship between the dissection flap characteristics (location, length, and thickness) and the propagation of the FL, which is not clear at present. This study employed porcine models to create an experimental circulation loop. The perfusion experiment was conducted using a FL without distal re-entry and a non-pulsating flow.
Usefulness of interactive video-based instruction on learning performance in relation to cognitive development of children with moderate intellectual disability
Authors: Barman Munmi , Jena Ananta Kumar 
Published: September 2023

The usefulness of information and communication technology has been witnessed around the globe with the occurrence of rapid changes in the field of education i.e. through the formal or informal way. For this, the researchers have assessed Interactive video-based instruction (IVBI) on ( N = 95; males = 47 & females = 48 age range between 12 and 15 years) moderate intellectual disability children in Guwahati, Assam, India from three day-care rehabilitation centres. The main objective was to examine the effect of IVBI intervention (IIVBI & CIVBI) on academic performance in association with the cognitive development of children with moderate intellectual disability in a comfortable setting within working hours. The findings conclude that children in the CIVBI group performed more actively as compared to IIVBI and comparison group, and it was due to the involvement of video-based instruction that helped understand the topic more precisely and acts effectively for CIVBI children in an experimental setting.