bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stabilitas Model Matematika Penularan Penyakit Mulut dan Kuku (PMK)
Authors: Sari Aulia Nurita , Maulana Dimas Avian 
Published: September 2023

Penyakit Mulut dan Kuku (PMK) adalah penyakit yang disebabkan oleh Foot-and-Mouth Disease Virus (FMDV) dari genus Apthovirus dan keluarga Picornaviridea yang menyerang semua hewan berkuku genap atau belah seperti sapi, kerbau, babi, kambing, domba dan termasuk satwa liar. Penyakit ini bukan termasuk zoonosis (penyakit yang dapat menular pada manusia). Penelitian ini bertujuan untuk memodelkan PMK secara matematis, mengetahui kestabilan, dan melakukan simulasi numerik model penyebaran PMK. Pada penelitian ini, populasi dibagi menjadi empat kompartemen yaitu rentan/suspectible (S), laten/latent (L), terinfeksi/infected (I) dan sembuh/recovered (R). Dari model SLIR ditentukan titik kesetimbangan bebas penyakit dan titik kesetimbangan endemik, kemudian dianalisis kestabilannya dengan menggunakan kriteria Routh-Hurwitz. Selanjutnya ditentukan bilangan reproduksi dasar (R0) dan dilakukan analisis sensitivitas terhadap . Berdasarkan hasil analisis kestabilan pada model SLIR, titik kesetimbangan bebas penyakit stabil jika R0 < 1 yang artinya PMK akan menghilang dan titik kesetimbangan endemik stabil jika R0 > 1 yang artinya PMK akan tetap ada dan menjadi endemik. Hasil simulasi numerik dapat diketahui bahwa terjadi endemik PMK di Provinsi Jawa Timur, hal ini diperkuat dengan nilai R0 = 1,16 yang berarti R0 > 1. Berdasarkan analisis sensitivitas terhadap tingkat masa inkubasi merupakan parameter yang sensitif. Berdasarkan hasil simulasi numerik dengan mengubah nilai parameter tingkat masa inkubasi dapat diketahui bahwa PMK akan menghilang seiring berjalannya waktu apabila hal ini diperkuat dengan R0 = 0,33.
Model Lotka-Volterra yang Mempertimbangkan Efek Ketakutan pada Prey dengan Fungsi Respon Holling Tipe II
Authors: Rahmawati Ruli , Savitri Dian 
Published: September 2023

Interaksi antar populasi pada ekosistem sawah antara burung hantu (Tyto alba) dengan tikus sawah (Rattus argentiventer) direpresentasikan sebagai model predator-prey yang mempertimbangkan efek ketakutan. Interaksi dua populasi ini menggunakan fungsi respon Holling tipe II. Model predator-prey ini dikonstruksi berdasarkan asumsi perilaku prey yaitu tikus sawah yang memiliki efek ketakutan terhadap predator burung hantu. Berdasarkan beberapa jurnal rujukan yang dikembangkan dengan pola pemangsaan menggunakan fungsi respon Holling tipe II. Analisis perhitungan pada penelitian ini dilakukan dengan mencari titik kesetimbangan dan analisis kestabilan. Hasil analisis didapatkan titik kesetimbangan , , dan dengan A = > 0, B = , C = . Hasil analisis kestabilan didapatkan titik E0 = (0,0) tidak stabil, E1 = ( ,0) stabil dengan syarat artinya kepunahan populasi predator terjadi saat konversi biomassa prey ke predator lebih besar dari kompetisi intra spesies prey, titik dan stabil dengan syarat g > µ artinya populasi prey dan predator tetap ada saat konversi biomassa prey ke predator lebih dari kematian alami predator. Simulasi numerik dilakukan untuk mengetahui kesesuaian hasil analisis dengan menggunakan aplikasi Phyton. Hasil simulasi numerik terhadap solusi sistem didapatkan konversi biomassa prey ke predator dengan berpengaruh pada kestabilan kedua populasi.
Kata Kunci: Lotka-Volterra, efek ketakutan, Holling II.
Optimizing Error of High-Dimensional Statistical Queries Under Differential Privacy
Authors: McKenna Ryan , Miklau Gerome , Hay Michael , Machanavajjhala Ashwin 
Published: September 2023

In this work we describe the High-Dimensional Matrix Mechanism (HDMM),a differentially private algorithm for answering a workload of predicate counting queries. HDMM represents query workloads using a compact implicit matrix representation and exploits this representation to efficiently optimize over (a subset of) the space of differentially private algorithms for one that is unbiased and answers the input query workload with low expected error. HDMM can be deployed for both ϵ-differential privacy (with Laplace noise) and (ϵ, δ)-differential privacy (with Gaussian noise), although the core techniques are slightly different for each. We demonstrate empirically that HDMM can efficiently answer queries with lower expected error than state-of-the-art techniques, and in some cases, it nearly matches existing lower bounds for the particular class of mechanisms we consider.
"I need a better description": An Investigation Into User Expectations For Differential Privacy
Authors: Cummings Rachel , Kaptchuk Gabriel , Redmiles Elissa 
Published: September 2023

Despite recent widespread deployment of differential privacy, relatively little is known about what users think of differential privacy. In this work, we seek to explore users' privacy expectations related to differential privacy. Specifically, we investigate (1) whether users care about the protections afforded by differential privacy, and (2) whether they are therefore more willing to share their data with differentially private systems. Further, we attempt to understand (3) users' privacy expectations of the differentially private systems they may encounter in practice and (4) their willingness to share data in such systems. To answer these questions, we use a series of rigorously conducted surveys (n=2424).

We find that users care about the kinds of information leaks against which differential privacy protects and are more willing to share their private information when the risks of these leaks are less likely to happen. Additionally, we find that the ways in which differential privacy is described in-the-wild haphazardly set users' privacy expectations, which can be misleading depending on the deployment. We synthesize our results into a framework for understanding a user's willingness to share information with differentially private systems, which takes into account the interaction between the user's prior privacy concerns and how differential privacy is described.
To assess the impact of prior urethral dilatation or DVIU on the outcome of anterior urethroplasty.
Authors: Tanzeel ur Rahman Gazder  , Kanwal Naz  , Vikram Seetlani  , Syed Rabiullah  , Usman Qamar  , Mazahir Zulfiqar  , Hamza Akhter  , Saeed Abdi  , Manzoor Hussain  
Published: September 2023

Background: Male urethral stricture has remained the major problem in urologic practice. Patients presenting with urethral stricture disease are commonly managed by dilatation, DVIU, and urethroplasty.
Methodology: This is a descriptive study of male patients who underwent anterior urethroplasty at our setup from 5th August 2021 to 25th February 2022. We analyzed the age, duration, type, length, and location of the stricture and the surgical treatment outcome after urethroplasty. The post-operative catheter was removed after 3 weeks, and UFM is advised. Qmax (max flow rate) > 15 ml/sec was measured on UFM (uroflowmetry) on the 1st week, 6 weeks, and followed on 3 months. Final outcome in terms of success was assessed by uroflowmetry. A maximum urine flow greater than 15mL/s after 3 months’ treatment assessed by uroflowmetry was considered as success.
Results: In our study, the blood loss in group A and group B patients, those patients who had DVIU or dilation in the past, had more bleeding during surgery than those who did not have a history of surgery. 66.67% of group B patients have bleeding from 200 ml to 500 ml, which is higher than group A patients. In our study, we found that if the patient had undergone surgery or no surgery had taken place before urethroplasty, the results in terms of UFM were quite similar, as in group A, 96.69% of patients had UFM more than 15 ml/sec, and in group B 87.88% had UFM more than 15 ml/sec.
Conclusion: Urethral dilatation or DVIU delays definitive treatment and increases operative challenges by increasing the length of stricture, more adhesion, and more fibrosis but has minimal impact on the outcome of urethroplasty success.
Determing the success rate of extracorporeal shock wave lithotripsy in renal pelvis stone of 1-2 cm in size.
Authors: Nisar Ahmed  , Tanzeel Gazder  , Hafiz Saad  , Khan Ajmal , Syed Rabiullah  , Mazahir Zulfiqar  , Usman Qamar  , Munawar Khaliq  , Saeed Abidi  , Manzoor Hussain  
Published: September 2023

Background: Despite its historical significance, ESWL has witnessed changes in its role, necessitating refined technical approaches and stringent patient selection criteria for optimal outcomes. This study aims to assess the efficacy of extracorporeal shock wave lithotripsy (ESWL) for treating renal pelvis stones ranging from one to two centimeters in size.Methodology: A descriptive case series was conducted at the Department of Urology and Renal Transplantation, SIUT, Karachi. The study enrolled 81 patients aged 20 to 60, of both genders, with a single renal pelvis stone sized 1 2 cm. Patients with ureteral obstruction were excluded. Informed consent was obtained before performing extracorporeal shock wave lithotripsy (ESWL). Follow ups were carried out regularly, and final success was assessed one month post ESWL session.Results: The mean age of participants was 41.93 ± 9.67 years, with the majority (54.32%) falling within the 41 to 60 age range. Out of 81 patients, 49 (60.49%) were male and 32 (39.51%) were female, resulting in a male-to-female ratio of 1.5:1. The mean stone size was 14.22 ± 2.01 mm. In the study, the success rate of ESWL for renal pelvis stones sized 1-2 cm was 85.19%, with 69 patients showing successful outcomes.Conclusion: In conclusion, the success rate of ESWL for treating renal pelvis stones sized 1-2 cm is notably high. This finding underscores the effectiveness of this non-invasive procedure in managing such cases.
Frequency of complications of transurethral pneumatic lithotripsy in pediatric bladder stone disease.
Authors: Farman Ullah  , Tanzeel Gazder  , Sanjeet Therani  , Izhar Ali  , Hamza Akhtar  , Usman Qamar  , Syed Rabiullah  , Mazahir Zulfiqar  
Published: September 2023

Background: Despite advancements, underdeveloped countries continue to face the burden of widespread illness causing pain, often attributed to factors like low nutrition and recurring infections, particularly vitamin A deficiency.
Methodology: This descriptive study employed a non probability convenient sampling technique and was conducted at the Urology Department of Lady Reading Hospital, Peshawar. The investigation spanned six months from January 25, 2019, to June 25, 2019. The study encompas sed a cohort of 369 patients, each subjected to comprehensive urine tests and detailed history and physical examinations. Procedures were performed under general anesthesia, utilizing Pediatric URS and pneumatic intracorporeal lithotripsy with Swiss lithoc last for bladder stone treatment. A 48 hour post treatment observation period assessed common intraoperative and postoperative consequences of transurethral pneumatic lithotripsy, including hematuria, bladder perforation, acute urine retention, and fever.
Results: Among the participants, 32% were female, and 68% were male. Notably, 5% experienced bladder perforation, 7% had hematuria, 4% exhibited acute urinary retention, and 7% presented with fever.
Conclusion: This study highlights complications of transurethral pneumatic lithotripsy in pediatric bladder stone disease, including bladder perforation, hematuria, acute urinary retention, and fever, providing crucial insights for clinical decisions.
ALIVE Biofeedback HRV training for Treating Insomnia: A Pilot Randomized Controlled Study.
Authors: Yusra Saleem  , Ujala Sajid  , Shamoon Noushad  , Sadaf Ahmed  
Published: September 2023

Background: Insomnia is a common sleep disorder that affects a large portion of the population. While several treatments are available, such as medication and cognitive-behavioral therapy, some individuals may not respond well to these treatments. Biofeedback, a technique that provides individuals with real-time feedback on their physiological responses, has shown promise in treating insomnia. This study aimed to investigate the effectiveness of ALIVE biofeedback HRV training in treating insomnia.
Methodology: This pilot study utilized a randomized controlled trial design to investigate the efficacy of ALIVE biofeedback intervention in individuals diagnosed with insomnia. A total of 60 participants with insomnia were randomly assigned to either the ALIVE biofeedback or control group. The ALIVE biofeedback group received a six week intervention involving relaxation techniques, deep breathing exercises, and mindfulness meditation using the ALIVE Pioneer system for heart rate variability (HRV) biofeedback training. The control group received standard care for insomnia. Outcome measures included HRV parameters, blood pressure, the Pittsburgh Sleep Quality Index Japanese version (PSQI J), and the Insomnia Severity Index (ISI).
Results: The ALIVE biofeedback group showed significant improvements in heart rate variability (HRV) parameters, including increased SDNN and RMSSD and high-frequency power (HF) after the 6-week intervention. The control group did not display significant changes in HRV. Additionally, the ALIVE biofeedback group significantly decreased diastolic blood pressure. Regarding sleep outcomes, the ALIVE biofeedback group reported increased sleep duration and decreased sleep disturbances, as indicated by the PSQI-J scores. Furthermore, participants in the ALIVE biofeedback group significantly improved their ISI scores. These findings suggest that the ALIVE biofeedback intervention can potentially improve HRV, blood pressure, sleep quality, and insomnia severity in individuals with insomnia.
Conclusion: It is concluded from the study results that the ALIVE biofeedback training is a non-invasive and effective treatment for insomnia.
Crystal and magnetic structures of solid solutions based on BiFeO3
Authors: Karpinsky D. V. , Latushkа S. I. , Zheludkevich D. V. , Chobot A. N. , Kruplevich V. C. , Dolgiy V. K. , Latushkа T. V. , Neklyudov K. N. , Silibin M. V. , Budemko E. V. 
Published: September 2023

The correlation between the multiphase state of the system and its magnetic properties was studied on Bi1–xEuxFeO3 ceramic samples in the range 0.12 ≤ x ≤ 0.18. The X-ray diffraction results indicate that, with an increase in the concentration of Eu ions, a structural transition from the rhombohedral (R3c) to nonpolar orthorhombic (Pnma) phase is observed through the partial formation of an antipolar orthorhombic structure (Pbam). The mixed phase state in the obtained compounds is observed in the range 0.12 ≤ x ≤ 0.16. Magnetic measurements in a strong magnetic field indicate a weak ferromagnetic interaction. The magnetic response in a strong field is explained by the location of the spins at the phase boundary, as well as by the presence of intrinsic antiferromagnetic spins.
Elastification of the arterial wall by high-intensity low-frequency ultrasound
Authors: Adzerikho I. E. , Kulak A. I. , Vladimirskaya T. E. , Leonchik T. V. , Chur S. N. , Minchenya V. T. , Shil’ko S. V. 
Published: September 2023

A significant increase in the elasticity of the femoropopliteal artery segments in vitro was found as a result of the action of cavitation generated by powerful low-frequency (24–26 kHz) ultrasound introduced into the vessel by a flexible waveguide. The vessel elasticity was evaluated both by the deflection under the action of an external force and by the degree of its expansion vasodilatation by the internal pressure created by the expanding balloon. The possibility of achieving a more than two-fold decrease in the vascular wall elasticity modulus after 30-s exposure to an ultrasound intensity of 31 W/cm2 was shown. It has been established that at the 10 μm amplitude of ultrasonic vibrations, vascular wall damage occurs in the form of small foci of detachment and rupture of the intima accompanied by delamination in the media layer, when polymorphic slit-like cavities are formed with an increase in the amplitude of oscillations above 23 μm.
Influence of interruptions in radiation therapy on long-term results of treatment of stage I-III head and neck cancers in the absence of surgical and chemoradiotherapy
Authors: Batyan A. N. , Valantsevich V. N. , Hancharova K. V. , Dziameshka P. D. , Lemiasheuski V. O. 
Published: September 2023

Despite the fact that head and neck tumors are very sensitive to radiation treatment, patients who have completed a course of radiation therapy have a high rate of recurrence and mortality from the underlying disease.The aim of the study was to analyze the event-free survival of patients who completed a course of radiation therapy for stage I-III head and neck cancer according to a radical program under the influence of a number of independent factors such as age, gender, total focal dose, disease stage, duration of a break in a split course of radiation therapy.The effect of the duration of interruption on survival was assessed by analyzing the treatment regimens for patients who received radiation treatment for stage I-III head and neck cancer according to a radical program from 2016 to 2018 at the Brest Regional Oncological Dispensary. Statistical processing of the obtained data included the analysis by the Cox regression method. Data were analyzed using the Kaplan-Meier method to evaluate the outcome.In the multivariate analysis, it was found that the disease stage has the greatest relationship with event-free survival (p < 0.01). The same trend is observed for the duration of interruption in radiotherapy (p < 0.05). The cumulative survival was significantly higher in the group of patients with treatment interruption of less than 3 weeks compared to the group of patients who completed treatment more than 3 weeks apart (80.00 % vs 49.06 %). If the duration of the break is less than 3 weeks, the clinical stage (T1-T3) is not a factor influencing patient survival.Accounting for the effect of interruptions in the course of radiotherapy and the understanding the influence of controllable factors is essential for optimal treatment strategies.
Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model
Authors: Pashkevich S. G. , Rubnikovich S. P. , Kuznetsova T. E. , Kuzmenko E. V. , Mironova G. P. , Tikhonovich O. G. , Gladkova Zh. A. , Zhogal K. N. , Serdyuchenko N. S. , Grishchenkov A. S. 
Published: September 2023

The article presents the results of structural and functional transformations in cerebellum, trigeminal nuclei, and hippocampus of male Wistar rats against the background of injection of mesenchymal stem cells (MSCs) into Meckel’s space in the temporomandibular joint (TMJ) inflammation model.The aim of the study was to clarify the effect of MSCs injections into Meckel’s space on the morphostructural features of cerebellum, trigeminal nuclei, and hippocampus in the TMJ inflammation model.Injecting the mesenchymal stem cells into Meckel’s space in an inflammatory model of the right lower temporomandibular joint promotes the structure restoration of the ganglionic layer of the cerebellum, the spinal nuclei of the trigeminal nerve, and the hippocampus of rats by the 28th day. This is manifested in increasing the neuronal density, decreasing the neurodegeneration index, and in activating glia elements.
Diagnostic significance of determining TREC and KREC T- and B-cell receptor rearrangement products in patients with inborn immune errors
Authors: Polyakova E. A. , Stegantseva M. V. , Guryanova I. E. , Lutskovich D. V. , Skapavets K. Y. , Liubushkin A. V. , Volodashchik T. P. , Kazak V. I. , Skibo Yu. V. , Belevtsev M. V. 
Published: September 2023

Inborn immunity errors such as primary immunodeficiencies in children represent a significant problem for public health, and it is undeniably important to improve the laboratory diagnosis of this pathology by creating new, effective methods for early detection of disorders involving immune mechanisms.The ROC analysis was used to evaluate the diagnostic significance of determining the copy number of T- and B-cell receptor DNA circle fragments (TREC/KREC) by multiplex real-time PCR in patients with a genetically determined diagnosis of primary immunodeficiency.Peripheral blood DNA samples of healthy children (n = 98) aged 0.0 (0-15.0) years, who constituted the control group, and of patients with genetically confirmed primary immunodeficiency (n = 95) aged 7.2 (0.1-18.0) years were examined.It has been established that determining the number of T and B cell receptor rearrangement products (TREC and KREC) has a high diagnostic significance in severe combined immunodeficiency, chromosomal instability syndromes such as ataxiateleangioectasia and Niimegen syndrome, diseases associated with immune dysregulation, agammoglobulinemia. Determining TREC and KREC is not informative in immunodeficiencies with non-lymphoid cell dysfunction or disorders that do not affect T- and B-cell receptor gene rearrangement such as the Wiskott-Aldrich syndrome and the chronic granulomatous disease.Determining TREC, KREC has a high diagnostic significance and can be applied in diagnosis of congenital immunity errors associated with T- and B-cell lymphopenia.
IN SILICO STUDY OF DERIVATIVE COMPOUNDS OF GALANGAL PLANTS AS ANTI-INFLAMMATORY
Authors: Aryasa I Wayan Tanjung , Sugianta I Kadek Arya 
Published: September 2023

Inflamasi merupakan dasar patogenesis dari beberapa penyakit baik penyakit bersifat degeneratif maupun non-degeneratif. Tumbuhan lengkuas yang umumnya terdapat di Indonesia biasa digunakan sebagai obat tradisional untuk beberapa penyakit dan juga memiliki senyawa metabolit sekunder yang bermanfaat sebagai antiinflamasi. Di dalam penelitian menggunakan pendekatan secara in silico berupa docking molekuler yang telah diterapkan pada 5 senyawa turunan dari tumbuhan lengkuas ke target molekuler inflamasi penting seperti reseptor siklooksigenase-2 (COX-2). Analisis aktivitas biologis senyawa turunan dari tumbuhan lengkuas menggunakan server WAY2DRUG PASS prediction. Hasil prediksi sifat fisikokimia senyawa turunan dari tumbuhan lengkuas menggunakan server SWISS-ADME. Penelitian ini bertujuan untuk memprediksi kemampuan dari 5 senyawa turunan dari tumbuhan lengkuas dalam menghambat enzim COX-2. Informasi terperinci telah diperoleh dengan menggunakan pendekatan docking molekuler. Simulasi docking untuk 5 senyawa turunan dari tumbuhan lengkuas telah dilakukan melalui aplikasi Autodock 4.2 yang tertanam didalam aplikasi MGL Tools 1.5.6. Interaksi molekular senyawa turunan dari tumbuhan lengkuas terhadap reseptor COX-2 divisualisasikan menggunakan perangkat lunak Discovery Studio (Biova). Berdasarkan hasil penelitian yang telah dilaksanakan dapat disimpulkan bahwa senyawa uji Galanganal memiliki afinitas yang paling baik jika dibandingkan dengan senyawa Galanganol A, Galanganol B, Galanganol C dan Galangin. Hal tersebut dapat dilihat dari nilai energi bebas ikatannya sebesar -8,98 kcal/mol dan konstanta inhibisinya sebesar 261,59 nM. Hasil ini menunjukkan bahwa senyawa uji Galanganal memiliki potensi sebagai agen antiinflamasi. Namun, penelitian lanjutan adalah perlu mengkaji lebih banyak senyawa turunan dari tumbuhan lengkuas untuk mengisolasi konformasi yang terbaik.