bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plausible Photosynthetic Parameters that Contribute to Differences in Grain Protein Content among Rice Genotypes
Authors: Spoorthi Nagaraju , Mohan Ramesh , Vijayaraghavreddy Preethi , Abhishree Ramachandra , Chaitanya Purushothama , Sree Sheshshayee 
Published: August 2023

Abstract
Aim
Attempts to increase grain protein content (GPC) most often resulted in a reduction of yield in cereals. This trade-off between GPC and yield rises mainly because of shared source of reductants for carbon and nitrogen assimilation. The major intent of this study was to understand this trade-off between GPC and grain yield in rice.
Methods
Based on a previous study, we identified two genotypes contrasting GPC with comparable yield and photosynthesis. We articulated the interrelation between carbon and nitrogen assimilation to understand the phenomenon that led to higher GPC without compromising its yield among the contrasts. We also looked at how these genotypes behaved to ambient and low light intensities in terms of photosynthesis and protein synthesis under limiting electron source.
Results
Our findings suggested that under ambient light, the high GPC genotype has adopted the triose phosphate utilization limitation as a traffic switch to limit the flow of electrons to carbon assimilation and divert the excess electrons to other sinks. The diversion of extra electrons particularly to nitrite reduction is boosted by increased substrates from higher uptake, transport and metabolism of nitrogen in leaf. In low GPC genotype under ambient light intensity excess electrons were quenched in the form of heat.
Conclusions
These findings suggest that efficiency in utilization of electrons by adopting a switch called TPU limitation coupled with better remobilization efficiency can be a promising genotype for breeders to develop a high yielding variety complemented with high GPC.
Identifying 1q amplification and PHF19 expressing high-risk cells associated with relapsed/refractory multiple myeloma
Authors: Walker Brian , Johnson Travis , Sudha Parvathi , Liu Enze , Blaney Patrick , Morgan Gareth , Chopra Vivek , Santos Cedric Dos , Nixon Michael , Huang Kun , Suvannasankha Attaya , Zaid Mohammad Abu , Abonour Rafat 
Published: August 2023

Abstract

Multiple Myeloma is an incurable plasma cell malignancy with a poor survival rate that is usually treated with immunomodulatory drugs (iMiDs) and proteosome inhibitors (PIs). The malignant plasma cells quickly become resistant to these agents causing relapse and uncontrolled growth of resistant clones. From whole genome sequencing (WGS) and RNA sequencing (RNA-seq) studies, different high-risk translocation, copy number, mutational, and transcriptional markers have been identified. One of these markers, PHF19, epigenetically regulates cell cycle and other processes and has already been studied using RNA-seq. In this study a massive (325,025 cells and 49 patients) single cell multiomic dataset was generated with jointly quantified ATAC- and RNA-seq for each cell and matched genomic profiles for each patient. We identified an association between one plasma cell subtype with myeloma progression that we have called relapsed/refractory plasma cells (RRPCs). These cells are associated with 1q alterations, TP53 mutations, and higher expression of PHF19. We also identified downstream regulation of cell cycle inhibitors in these cells, possible regulation of the transcription factor (TF) PBX1 on 1q, and determined that PHF19 may be acting primarily through this subset of cells.
Green Synthesis and DFT study of Nickel Zinc Ferrite Nanoparticles: A Highly Sensitive Room Temperature VOC Sensing Material
Authors: Mukherjee Chandra , Choudhury Subhankar , Baildya Nabajyoti , Ghosh Narendra Nath , Misra Debabrata , Das J. 
Published: August 2023

Abstract
In the present communication, nanocrystalline nickel zinc ferrite (NZF) has been prepared by co-precipitation method in varied proportions and their alcohol (primary alcohols viz. ethanol, propanol and butanol) sensing behaviour at room temperature is studied. Nanocrystalline nickel zinc ferrite (NZF) Ni1-xZnxFe2O4 (where x = 0.3, 0.5 and 0.7) with varied molar concentration has been successfully prepared by coprecipitation method at controlled spin and temperature. The structural and surface morphological characterizations, porosity and surface activity of the prepared NZFs have been analyzed by Powder X-ray Diffraction (PXRD) and Field Emission Scanning Electron Microscopy (FESEM). The variations in electrical resistance of Ni0.7Zn0.3Fe2O4 (NZF1), Ni0.5Zn0.5Fe2O4 (NZF2) and Ni0.3Zn0.7Fe2O4 (NZF3) are measured with the exposure of 500 ppm ethanol, propanol and butanol vapours as a function of time at room temperature. 89% sensitivity is shown by NFZ1 for 500 ppm of the ethanol vapour at the same experimental condition. The sensing response followed the order of ethanol > propanol > butanol for all the three samples. The increasing trend of VOC (volatile organic substance) sensing properties by NZFs has been verified through extensive DFT (density functional theory) analysis by adopting PAW (projector augmented wave) technique. DFT calculation supports the pulling effect of Ni atoms in NZF nanoparticles which consequently increases the sensing properties of the prepared NZF nanomaterials. ELF (Electron localization function) study also supports the accelerated adsorption capacity of nickel doped nanoferrites.
Effect of heat and mass transfer on the nanofluid of peristaltic flow in a ciliated tube
Authors: Abd-Alla Abdelmooty , Abo-Dahab S. M. , Abdelhafez M. A. , Elmhedy Y. 
Published: August 2023

Abstract
This technical study analyzes heat and mass transfer effects on the flow of a peristaltic flow, incompressible, nanofluid via a ciliated tube. The investigation considers the approximation of long wavelength and low Reynolds number. The flow is examined in wave frame of reference moving with the velocity c. The governing equations have been solved to determine velocity, temperature, concentration, the gradient pressure, rise pressure and the friction force. Using MATLAB R2023a software, a parametric analysis is performed, and the resulting data is represented graphically. The results indicate that the various emerging parameters of interest significantly affect the fluid properties within the tube. The present study enhances the comprehension of fluid dynamics in tube and offers valuable insights into the influence of heat and mass transfer in such setups.
Impact of different components of the Skyrme nucleon-nucleon effective interaction on the nuclear density distribution
Authors: Seif W. M. , Hashem A. S. 
Published: August 2023

Abstract
We systematically investigate the impact of the different terms of the Skyrme energy density functional of the effective nucleon-nucleon interaction, and of its associated nuclear matter (NM) properties, on the density distributions of spherical nuclei. Twenty five Skyrme force parameterizations are examined simultaneously, covering a broad range of each characteristic parameter and NM property. The diffuseness and the neutron-skin thickness are found to be the most sensitive density quantities to the force parameterization. The diffuseness is indicated to decrease with increasing the central zero-range and the effective mass terms of the effective force, and the power σ of its density dependent term, as well as with the coefficient of the NM symmetry energy (a sym) and its density slope (L) at saturation density, and the incompressibility (K o). In contrast, the proton and neutron diffuseness tend to increase with increasing the spin-orbit force and the isoscalar effective nucleon-mass (m*), and to increases slightly with the density dependence parameters other than the power σ. Opposite impacts are pointed out for the different parts of the finite-range, and J 2 tensor terms on the proton and neutron density. While the neutron-skin thickness tends to increase significantly upon increasing the central zero-range and spin-orbit force terms, a sym , L, and K o , and to increase slightly with the finite-range and J 2 tensor terms, and σ, it decreases with the effective-mass term, the density-dependence exchange parameter, and with the indicated isoscalar effective mass. The proton and neutron radii exhibit decreasing behavior with the central zero-range and the spin-orbit terms, and with K o , and m*. Increasing a sym and L indicate slightly less (larger) proton (neutron) radius.
Early diagnosis of aortic calcification through dental X-ray examination for dental pulp stones
Authors: Ishikawa Misao , Kanzaki Hiroyuki , Kodera Ryo , Sekimizu Takehiro , Wada Satoshi , Tohyama Syunnosuke , Ida Tomomi , Shimoyama Miho , Manase Shugo , Tomonari Hiroshi , Kuroda Noriyuki 
Published: August 2023

Abstract
Vascular calcification, an ectopic calcification exacerbated by aging and renal dysfunction, is closely associated with cardiovascular disease. However, early detection indicators are limited. This study focused on dental pulp stones, ectopic calcifications found in oral tissues that are easily identifiable on dental radiographs. Our investigation explored the frequency and timing of these calcifications in different locations and their relationship to aortic calcification. In cadavers, we examined the association between the frequency of dental pulp stones and aortic calcification, revealing a significant association. Notably, dental pulp stones appeared prior to aortic calcification. Using a rat model of hyperphosphatemia, we confirmed that dental pulp stones formed earlier than calcification in the aortic arch. Interestingly, there were very few instances of aortic calcification without dental pulp stones. Additionally, we conducted cell culture experiments with vascular smooth muscle cells (SMCs) and dental pulp cells (DPCs) to explore the regulatory mechanism underlying high phosphate–mediated calcification. We found that DPCs produced calcification deposits more rapidly and exhibited a stronger augmentation of osteoblast differentiation markers compared with SMCs. In conclusion, the observation of dental pulp stones through X-ray examination during dental checkups could be a valuable method for early diagnosis of aortic calcification risk.
Nuclear quantum effects made accessible: local-density fitting in multicomponent methods
Authors: Mata Ricardo , Hasecke Lukas 
Published: August 2023

Abstract
The simulation of nuclear quantum effects (NQE) is crucial for an accurate description of systems and processes involving light nuclei such as hydrogen atoms. Within the last years, the importance of those effects has been highlighted for a vast range of systems with tremendous implications in chemistry, biology, physics and material sciences. However, while electronic structure theory methods have become routine tools for quantum chemical investigations, there is still a lack of approaches to address NQE which are as computationally accessible and straightforward to use. In an important step forward to change this scenario, we present the first combination of the Nuclear-Electronic Orbital Hartree-Fock approach with both local and density fitting approximations (LDF-NEO-HF). This results in a low-order scaling approach which enables the inclusion of nuclear quantum effects for large systems within a fraction of a day and for small to medium size systems in minutes. Moreover, we demonstrate the qualitative accuracy and robustness of our approach to retrieve NQEs for three real use cases motivated by chemical, biological and material science applications.
Tophi and Carotid Atherosclerosis in Gout patients: Role of Insulin Resistance
Authors: Si Ke , Chi Jingwei , Xu Lili , Dong Bingzi , Huang Yajing , Zhang Haowen , Chen Ying , Wang Yangang 
Published: August 2023

Abstract
Objective
Gout and cardiovascular disease are closely related, but the mechanism linking them is still unknown. Gout may affect the insulin signalling pathway inducing insulin resistance (IR). The study aims to evaluate the association between tophi and carotid atherosclerosis, considering the potential role of IR.
Methods
A total of 595 patients with gout aged 18 to 80 were enrolled in this study. Carotid intima-media thickness, plaques and tophi were evaluated by B-mode ultrasonography. IR was assessed by the HOMA index (hepatic IR) and Gutt index (peripheral IR). Multivariable logistic regression and interaction analysis were used to examine the the accociation between tophi and IR and its impact on carotid atherosclerosis.
Results
Among these participants, the average age was 55.4 (± 12.54) years, and 94.6% were male. Tophi were associated with increased odds of carotid atherosclerosis and burden after adjustment for confounders (P < 0.05). Tophi and IR synergically interacted for inducing carotid atherosclerosis. And the interaction between peripheral IR with tophi was more pronounced than hepatic IR with tophi.
Conclusions
Tophi were independently associated with carotid atherosclerosis risk. IR mediated a significant amount of the effect of tophi on the development of carotid atherosclerosis. Peripheral IR probably plays a more important role than hepatic IR does.
In vivo Knee Kinematics during Step-up Activity after Medial Opening Wedge Distal Tuberosity　Osteotomy of the Proximal Tibia with Hemicallotasis
Authors: Okamoto Nobukazu , Nakamura Eiichi , Masuda Tetsuro , Hisanaga Satoshi , Miyamoto Takeshi 
Published: August 2023

Abstract
Purpose
Hemicallotasis osteotomy (HCO), a type of medial opening wedge distal tuberosity osteotomy of the proximal tibia (OWDTO), aims to correct the alignment of knees with osteoarthritis (OA). HCO shifts the weight burden to the lateral compartment, facilitating the transfer of load from the medial compartment of the joint line to the lateral compartment. This technique results in reduced compartmental pressure on the medial articular surface, and fewer knee adduction movements. However, HCO’s impact on knee joint kinematics is currently unclear. Therefore, we conducted a 3-dimensional analysis of the in vivo dynamics during stair-climbing motions, before and after HCO.
Methods
Six out of 13 patients who underwent HCO to treat unilateral medial knee OA were included in this study. The mean age of subjects at the time of HCO was 61 ± 6 years. Subjects performed the ascending motion using a step platform preoperatively, and 1 year postoperatively, and fluoroscopic lateral images were taken on both occasions. Three-dimensional kinematic analysis was conducted using the model-based image-matching technique.
Results
The tibias exhibited a pattern of external rotation according to the degree of extension, both preoperatively (10°±3°) and postoperatively (8°±4°), but these differences were not significant. Additionally, no significant differences were observed in the anteroposterior movement of the femoral condyles, before and after HCO. The lateral femoral condyle was shifted by 10 ± 1 mm from the flexion position to the extension position prior to HCO, and 9 ± 1 mm postoperatively.
Conclusion
Although no significant differences were observed during this study, it is possible for the medial pivot movement to decrease during HCO due to the shift in the center of gravity to the lateral side of the joint line.
3D Printed Mechanical Robust, Anti-swellable Cellulose derived Liquid-free Ionic Conductive Elastomer for Multifunctional Underwater Electronic Skin
Authors: Lu Chuanwei , Wang Xinyu , Shen Yi , Xu Shijian , Wang Chunpeng , Zhang Daihui , Huang Caoxing , Wang Jifu , Yong Qiang , Chu Fuxiang 
Published: August 2023

Abstract
Ionic gel-based wearable electronic devices with robust sensing performance have gained extensive attention. However, the development of mechanical robust, multifunctional, and water resistance ionic gel-based wearable sensors still is a challenge because of their intrinsic structure weakness such as swelling-induced function degradation in a water environment. Herein, we first report the preparation of 3D printed cellulose derived ionic conductive elastomers (ICEs) with high mechanical toughness, multifunctional, and water/organic solvent resistance through one-step photo-polymerization of polymerizable deep eutectic solvents. The well-defined structural design combining multiple hydrogen bonds with strong coordination bonds allows the ICE to be stabilized in aquatic environments. The introduction of polyaniline modified carboxylate cellulose nanocrystals (C-CNC@PANI) not only yields a high conductivity (58.7 mS/m) but also contributes to constructing dense networks to achieve extremely high mechanical strength (4.4 MPa), toughness (13.33 MJ*m-3), elasticity and improved anti-swelling performance. Given these features, the ICE-based multifunctional sensor is used for real-time detecting human motions, respiration, and body temperature. More importantly, the ICE-based sensor shows reliable underwater mechanosensing applications for accurately monitoring human movements in aqueous environments. This work provides a promising strategy for designing the new generation of strong, tough, multifunctional, and water-resistant wearable electronic devices that required multi-scene applications.
Lowering hippocampal miR-29a expression slows cognitive decline and reduces beta-amyloid deposition in 5xFAD mice
Authors: Mei Zhen , Liu Jiaqi , Schroeder Jason P , Weinshenker David , Duong Duc M. , Seyfried Nicholas T. , Li Yujing , Jin Peng , Wingo Aliza P. , Wingo Thomas S. 
Published: August 2023

Abstract
microRNA-29a (miR-29a) increases with age in humans and mice, and, in the brain, it has a role in neuronal maturation and response to inflammation. We previously associated higher miR-29a levels in human brain with faster antemortem cognitive decline, suggesting that lowering miR-29a levels could ameliorate memory impairment in the 5xFAD AD mouse model. To test this hypothesis, we generated an adeno-associated virus (AAV) expressing GFP and a miR-29a "sponge" or empty vector. We found that the AAV expressing miR-29a sponge functionally reduced miR-29a levels, and improved measures of memory in the Morris water maze and fear condition paradigms when sponge delivered to hippocampi of 5XFAD and WT mice. miR-29a sponge expression significantly reduced hippocampal beta-amyloid deposition in 5XFAD mice and lowered astrocyte and microglia activation in both 5XFAD and WT mice. Using transcriptomic and proteomic sequencing, we identified Plxna1 and Wdfy1 as putative effectors at the transcript and protein level in WT and 5XFAD mice, respectively. These data indicate that miR-29a promotes AD-like neuropathology and negatively regulates cognition, making it and its target genes attractive therapeutic targets for the treatment of neurodegenerative disease.
Case Report: A woman with schizophrenia who died due to Takotsubo cardiomyopathy occurring after electroconvulsive therapy
Authors: Muto Takahiro , Kyono Hotsumi 
Published: August 2023

Abstract
Background
Electroconvulsive therapy (ECT) is a safe treatment for treatment-resistant schizophrenia. However, it has some side effects, and Takotsubo cardiomyopathy is considered one of the minor complications. Several cases of patients developing Takotsubo cardiomyopathy during a course of ECT have been reported, but none have died. We present a case of post-ECT Takotsubo cardiomyopathy that became fatal.
Case presentation
We experienced a case of a 67-year-old woman who had delusions and catatonic symptoms due to schizophrenia but was resistant to several medications. Her symptoms improved by conducting ECT, but she had difficulty maintaining her improvement, which caused her to receive multiple courses of ECT. A month after her 6th course of ECT, the patient developed Takotsubo cardiomyopathy that had a fatal outcome.
Conclusion
Our patient had numerous cases of aspiration pneumonitis and malnutrition before ECT was preformed, which might have made this case fatal. In conclusion, appropriate supplementation of nutrition and reduction of physical stressors are important to avoid deaths from Takotsubo cardiomyopathy caused by ECT. Prescribing clozapine might have been a solution in the present case, but there are some difficulties, such as the restriction against prescribing this drug in Japan.
Evaluation of the local skin friction drag of turbulent boundary layers over cavities
Authors: Hoang Van-Thuan , Jafari Azadeh , Cazzolato Benjamin , Arjomandi Maziar 
Published: August 2023

Abstract
This research investigates the evaluation of the local friction drag of the turbulent boundary layers over cavities. Two indirect methods, including the composite profile method and the modified Clauser's chart method, were used to estimate the local friction drag of the turbulent boundary layers over a cavity array at four different downstream locations from the first row of the cavity array. Hot-wire probes were used to measure flow velocity at three different free-stream velocities. This resulted in a Reynolds number based on a momentum thickness from 1212 to 3040 and an inner-scaled cavity diameter from about 18 to 44. It was found that the friction coefficient of turbulent boundary layers over the cavity array was decreased compared with those over a smooth wall. A maximum reduction of about 15% was observed in the local skin friction of the turbulent boundary layers over the cavity array, compared to those of the turbulent boundary layers over a smooth wall. It is noted that the reductions in the local friction coefficients, measured at about 14 cavity array diameters from the array trailing edge, were smaller than those measured above the cavity array.
Near-infrared spectroscopy system for quantitative characterization of four biomarkers in biotissue oxygenation
Authors: Hovhannisyan Vladimir , Hu Yvonne Yuling , Chen Liang-Wei , Chen Hsin-Hung , Chang Shin-Tzu , Chen Shean-Jen 
Published: August 2023

Abstract
Near infrared spectroscopy (NIRS) is a valuable tool for noninvasive and quantitative analysis of biotissue, particularly within the spectral range of 670 to 1000 nm due to the inherent transparency. This technique facilitates the assessment of crucial chromophores including deoxyhemoglobin (Hb), oxyhemoglobin (HbO2) and the oxidized state of cytochrome c oxidase (CCO), enabling real-time evaluation of oxygenation and metabolism in human brain and other tissues in vivo. However, the influence of light scattering within tissues and its consequential impact on the accurate quantification of Hb, HbO2, and CCO concentrations were neglected in NIRS measurements. We have developed a portable real-time 4-wavelenght NIRS system to measure the variations in Hb, HbO2, and CCO concentrations, along with concurrent tracking of alterations in biotissue light-scattering characteristics. These measurements were conducted across various modes of respiration and blood circulation in vivo. It is shown that a more precise assessment of the contribution attributable to scattered light does play a significant role in the light absorption of Hb, HbO2 and CCO. Consequently, the precision of quantifying vital biomarker concentration shifts through NIRS technology is markedly enhanced. The assimilation of scattered light data enriches the understanding of oxygenation processes within tissue, thus augmenting the depth and breadth of insights attainable through NIRS studies conducted in vivo. By bridging the gap between light scattering and chromophore absorption, the realm of heightened accuracy and comprehensive physiological interpretation can be achieved.