bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of preoperative magnetic resonance image on survival rates and surgical planning in breast cancer conservative surgery: randomized controlled trial (BREAST-MRI trial)
Authors: Mota Bruna Salani , Reis Yedda Nunes , de Barros Nestor , Cardoso Natália Pereira , Mota Rosa Maria Salani , Shimizu Carlos , de Mello Tucunduva Tatiana Cardoso , de Siqueira Ferreira Vera Christina Camargo , Goncalves Rodrigo , Doria Maíra Teixeira , Ricci Marcos Desidério , Trinconi Angela Francisca , Camargo Cristina Pires , Riera Rachel , Baracat Edmund Chada , Soares Jr José Maria , Filassi José Roberto 
Published: February 2023

Abstract
Background
Breast magnetic resonance imaging (MRI) has high sensitivity in detecting invasive neoplasms. Controversy remains about its impact on the preoperative staging of breast cancer surgery. This study evaluated survival and surgical outcomes of preoperative MRI in conservative breast cancer surgery.

Methods
A phase III, randomized, open-label, single-center trial including female breast cancer participants, stage 0–III disease, and eligible for breast-conserving surgery. We compared the role of including MRI in preoperative evaluation versus radiologic exam routine with mammography and ultrasound in breast cancer conservative candidates. The primary outcome was local relapse-free survival (LRFS), and secondary outcomes were overall survival (OS), mastectomy rate, and reoperation rate.

Results
524 were randomized to preoperative MRI group (n = 257) or control group (n = 267). The survival analysis showed a 5.9-years LRFS of 99.2% in MRI group versus 98.9% in control group (HR = 0.72; 95% CI 0.12—4.28; p = 0.7) and an OS of 95.3% in the MRI group versus 96.3% in the control group (HR = 1.37 95% CI 0.59–3.19; p = 0.8). Surgical management changed in 21 ipsilateral breasts in the MRI group; 21 (8.3%) had mastectomies versus one in the control group. No difference was found in reoperation rates, 22 (8.7%) in the MRI group versus 23 (8.7%) in the control group (RR = 1.002; 95% CI 0.57–1.75; p = 0.85).

Conclusion
Preoperative MRI increased the mastectomy rates by 8%. The use of preoperative MRI did not influence local relapse-free survival, overall survival, or reoperation rates.
Globalising or assimilating? Exploring the contemporary function of regionalised global university rankings in Latin America
Authors: Darwin Stephen , Barahona Malba 
Published: February 2023

AbstractGlobal university rankings (GUR) have become increasingly influential as a proxy measure of higher education quality. The more recent development of regionalised forms of rankings has increased their global reach, drawing a greatly expanded range of institutions into their orbit. As a result, regionalised GUR have developed an increasing potential power to shape social perceptions, institutional actions, and everyday academic practices. In this paper, the perceived impact of regionalised forms of GUR is analysed from the perspective of Latin American higher education. Based on a critical meta-synthesis framed by a glonacal heuristic (Marginson and Rhoades, Higher Education 43:281–309, 2002), the tensions arising around the application of regionalised forms of global rankings are mapped. Specifically, the impact of rankings on conceptions of the mission of universities is foregrounded. The meta-synthesis identifies three primary tensions around the regional application of GUR in Latin American contexts: how conceptions of regional higher education quality are most effectively developed, how the local university is imagined under the weight of global expectations, and the relativised value of local agency in assessing quality outcomes. The findings suggest that GUR have created strong fissures in Latin American higher education regarding the missions of institutions, particularly in confronting the powerful hegemonies of the epistemologies of the Global North imposing themselves on Latin American higher education. The paper concludes that the stratification and social anxiety caused by the regional applications of GUR may not be necessarily productive in encouraging regional institutional diversity or in enhancing the local relevance of higher education.
Conduction system pacing: promoting the physiology to prevent heart failure
Authors: Tun Han Naung , Khan Hafiza , Chernikova Daryna , Mareev Yury , Chakrabarti Santabhanu , Thant May , Cannata Antonio 
Published: February 2023

Abstract
Cardiac conduction system pacing provides physiological ventricular activation by directly stimulating the conduction system. This review describes the two types of conduction system pacing: His bundle pacing (HBP) and left bundle area pacing (LBAP). The most significant advantage of HB pacing is that it can provide a regular, narrow QRS; however, the disadvantages are challenging implantation and a high risk of re-intervention due to lead dislodgement and the development of high pacing threshold. LBAP provides optimum physiological activation of the left ventricle by engaging the left bundle/fascicular fibers. LBAP is more physiological than traditional RV apical pacing and could be an attractive alternative to conventional cardiac resynchronization therapy (CRT). The advantages of LBAP are a relatively more straightforward implantation technique than HBP, better lead stability and pacing thresholds. HBP and LBAP are more physiological than right ventricular pacing and may be used instead of conventional pacemakers. Both HBP and LBBP are being investigated as alternatives to conventional CRT.
Existence of Optimal Control for Dirichlet Boundary Optimization in a Phase Field Problem
Authors: Wodecki Aleš , Balázsová Monika , Strachota Pavel , Oberhuber Tomáš 
Published: February 2023

AbstractPhase field modeling finds utility in various areas. In optimization theory in particular, the distributed control and Neumann boundary control of phase field models have been investigated thoroughly. Dirichlet boundary control in parabolic equations is commonly addressed using the very weak formulation or an approximation by Robin boundary conditions. In this paper, the Dirichlet boundary control for a phase field model with a non-singular potential is investigated using the Dirichlet lift technique. The corresponding weak formulation is analyzed. Energy estimates and problem-specific embedding results are provided, leading to the existence and uniqueness of the solution for the state equation. These results together show that the control to state mapping is well defined and bounded. Based on the preceding findings, the optimization problem is shown to have a solution.
On the nonlinear dynamics of a piezoresistive based mass switch based on catastrophic bifurcation
Authors: Azizi Saber , Madinei Hadi , Khodaparast Hamed Haddad , Faroughi Shirko , Friswell Michael I. 
Published: February 2023

AbstractThis research investigates the feasibility of mass sensing in piezoresistive MEMS devices based on catastrophic bifurcation and sensitivity enhancement due to the orientation adjustment of the device with respect to the crystallographic orientation of the silicon wafer. The model studied is a cantilever microbeam at the end of which an electrostatically actuated tip mass is attached. The piezoresistive layers are bonded to the vicinity of the clamped end of the cantilever and the device is set to operate in the resonance regime by means of harmonic electrostatic excitation. The nonlinearities due to curvature, shortening and electrostatic excitation have been considered in the modelling process. It is shown that once the mass is deposited on the tip mass, the system undergoes a cyclic fold bifurcation in the frequency domain, which yields a sudden jump in the output voltage of the piezoresistive layers; this bifurcation is attributed to the nonlinearities governing the dynamics of the response. The partial differential equations of the motion are derived and discretized to give a finite degree of freedom model based on the Galerkin method, and the limit cycles are captured in the frequency domain by using the shooting method. The effect of the orientation of the device with respect to the crystallographic coordinates of the silicon and the effect of the orientation of the piezoresistive layers with respect to the microbeam length on the sensitivity of the device is also investigated. Thanks to the nonlinearity and the orientation adjustment of the device and piezoresistive layers, a twofold sensitivity enhancement due to the added mass was achieved. This achievement is due to the combined amplification of the sensitivity in the vicinity of the bifurcation point, which is attributed to the nonlinearity and maximizing the sensitivity by orientation adjustment of the anisotropic piezoresistive coefficients.
Extending the usability of the force-flow based topology optimization to the process of generative design
Authors: Birosz Márton Tamás , Bátorfi János György , Andó Mátyás 
Published: February 2023

AbstractTopology optimization and Generative Design are two methods to create volume or stiffness optimized parts and they are used more frequently nowadays. However, the specific methods are often not well described and the connection between these two is not clearly explained. In this article, a force-flow based topology optimization process has been explained in detail and extended with a function to be able to use as a Generative Design tool. The proposed algorithm has been tested on three 2D shapes and the effectiveness was evaluated. This work clarifies the vague description of theoretical solutions by presenting in detail the operation of the algorithm and bridging the lack of information that exists between the shape or topology optimization procedure and the generative design solution.
MRI-based artificial intelligence to predict infection following total hip arthroplasty failure
Authors: Albano Domenico , Gitto Salvatore , Messina Carmelo , Serpi Francesca , Salvatore Christian , Castiglioni Isabella , Zagra Luigi , De Vecchi Elena , Sconfienza Luca Maria 
Published: February 2023

Abstract
Purpose
To investigate whether artificial intelligence (AI) can differentiate septic from non-septic total hip arthroplasty (THA) failure based on preoperative MRI features.

Materials and methods
We included 173 patients (98 females, age: 67 ± 12 years) subjected to first-time THA revision surgery after preoperative pelvis MRI. We divided the patients into a training/validation/internal testing cohort (n = 117) and a temporally independent external-testing cohort (n = 56). MRI features were used to train, validate and test a machine learning algorithm based on support vector machine (SVM) to predict THA infection on the training-internal validation cohort with a nested fivefold validation approach. Machine learning performance was evaluated on independent data from the external-testing cohort.

Results
MRI features were significantly more frequently observed in THA infection (P < 0.001), except bone destruction, periarticular soft-tissue mass, and fibrous membrane (P > 0.005). Considering all MRI features in the training/validation/internal-testing cohort, SVM classifier reached 92% sensitivity, 62% specificity, 79% PPV, 83% NPV, 82% accuracy, and 81% AUC in predicting THA infection, with bone edema, extracapsular edema, and synovitis having been the best predictors. After being tested on the external-testing cohort, the classifier showed 92% sensitivity, 79% specificity, 89% PPV, 83% NPV, 88% accuracy, and 89% AUC in predicting THA infection. SVM classifier showed 81% sensitivity, 76% specificity, 66% PPV, 88% NPV, 80% accuracy, and 74% AUC in predicting THA infection in the training/validation/internal-testing cohort based on the only presence of periprosthetic bone marrow edema on MRI, while it showed 68% sensitivity, 89% specificity, 93% PPV, 60% NPV, 75% accuracy, and 79% AUC in the external-testing cohort.

Conclusion
AI using SVM classifier showed promising results in predicting THA infection based on MRI features. This model might support radiologists in identifying THA infection.
An algebraic approach to symmetric linear layers in cryptographic primitives
Authors: Subroto Robert Christian 
Published: February 2023

AbstractSubterranean 2.0 is a permutation-based cipher suite which works with a 257 bit-state. It is designed for lightweight cryptography, and it scores very well with respect to energy consumption. Its security has been investigated by the designers against well-known attack vectors. A possible point of concern is the relatively low order of its linear layer, which equals 256. In the past, such properties have been exploited by invariant subspace attacks. We define linear mappings with a similar structure as the linear layer of Subterranean as SC-compositions. In this work, we explore finding SC-compositions with a higher order than 256. We rely on concepts from abstract algebra and number theory to understand the relation between the order and the bit-states of SC-compositions. Using a 257 bit-state as done in Subterranean is an unfortunate choice for designing such SC-compositions with a high order. We present two examples with different bit-states, each having a significantly higher order than 256.
Methodologies to reveal young Australian Indigenous students’ mathematical proficiency
Authors: Reid O’Connor Bronwyn 
Published: February 2023

AbstractA 7-month mathematics proficiency program was conducted in a primary Australian Indigenous community school. This paper focuses on outlining the specific methodologies employed to explore how students’ mathematical proficiency changed throughout the implementation of the program in Years 2 to 4 (~ 7 to 9 years old). A mixed methods research design was utilised, and findings will be presented to evidence how the combination of standardised tests, diagnostic tests, and Newman interviews were useful in capturing and making visible young Indigenous student’s mathematical proficiency. Whilst standardised tests provided a useful and comparable measure of student achievement, diagnostic tests and Newman interviews gave space for Indigenous student voice and demonstrated their strengths and areas for improvement in relation to their conceptual understanding, procedural fluency, and strategic competence. From these findings, recommendations concerning the adjustment of data collection procedures for young students in this setting are presented. The findings question the accuracy of standardised tests in revealing young students’ proficiency, and this has implications for the extent to which standardised tests are relied upon to inform educational reform particularly for Indigenous students. Striving for equitable educational outcomes is an important endeavour in Australia, and such undertakings must be driven by meaningful and accurate evidence of students’ proficiency in mathematics.
Mapping of total suspended solids using Landsat imagery and machine learning
Authors: Torres-Vera M.-A. 
Published: February 2023

AbstractThe main objective of this work is to propose a new technique for water quality parameters monitoring by applying artificial intelligence methods to optimize remote sensing data processing. A multiple regression model was developed to create a total suspended solids (TSS) prediction model, using unsupervised machine learning. Currently, water bodies throughout the world are poorly supervised in terms of quality, so it is necessary to implement efficient mechanisms to obtain synoptic information for a good diagnosis in TSS evolution, because they are a key indicator of the biophysical state of lakes and an essential marker for continuous monitoring. Conventional methods used to monitor the physical parameters of water bodies, for example, in situ sampling, have proven impractical due to time, cost and space constraints, and remote sensing tools can help to achieve this purpose more efficiently. The proposed multiple regression model requires calibration and to that end, Lake Chapala data from the monitoring time series collected by the National Water Commission (CONAGUA) were used. Lake Chapala is the largest freshwater body in Mexico, and the human intervention that develops around the lake has caused drastic changes such as decrease in the size of the lake and increase in suspended matter and aquatic vegetation. These changes alter the balance of the system, endangering the health of the lake. This work presents a generalized semi-empirical model that uses Landsat image data and machine learning methods for estimating total suspended solids (TSS) in water bodies, with a good prediction precision (R = 0.81, RMSE = 32.52).
Avian ichnofauna from Sierra de las Cabras tracksite (late Miocene, Jumilla, SE Spain)
Authors: Herrero Cayetano , Herrero Emilio , Martín‑Chivelet Javier , Pérez‑Lorente Félix 
Published: February 2023

AbstractThe Sierra de las Cabras (Lat. 38° 28′ 53″N, Lon. 1° 24′ 52″W) is an exceptional ichnofossil site of late Miocene age, located in the Prebetic ranges near the town of Jumilla (Murcia Province, SE Spain). The site contains abundant vertebrate ichnofauna preserved in carbonate facies that were deposited in a semi-arid wetland system with shallow ponds and marshes. The ichnofauna includes diverse mammal footprints and trackways, which have been recently studied, as well as bird ones, which are the target of this paper. We report a total of 51 avian footprints spread over two of the three track-bearing stratigraphic surfaces of the site. The detailed study of these ichnites (footprints and trackways) allows their attribution to the ichnogenus Fuscinapeda (Sarjeant and Langston, Texas Memorial Museum Bulletin 36:1–86, 1994), as well as to infer diverse patterns of bird’s behavior consistent with shallow water wetlands avifauna. Also, we discuss about the possible trackmakers, which should correspond to walking birds characterized by long legs, with no hallux or a raised one, which could probably belong to the Gruiformes order. The study confirms the presence of Fuscinapeda in the Iberian Peninsula and completes the characterization of the vertebrate ichnofauna of Sierra de las Cabras, a site that joins the nearby Hoya de la Sima ichnofossil site to yield the largest and most diverse record of vertebrate ichnites of late Miocene age in southern Iberia.
Patient Assessment and Therapy Planning Based on Homologous Recombination Repair Deficiency
Authors: Li Wenbin , Gao Lin , Yi Xin , Shi Shuangfeng , Huang Jie , Shi Leming , Zhou Xiaoyan , Wu Lingying , Ying Jianming 
Published: February 2023

Abstract
Defects in genes involved in the DNA damage response cause homologous recombination repair deficiency (HRD). HRD is found in a subgroup of cancer patients for several tumor types, and it has a clinical relevance to cancer prevention and therapies. Accumulating evidence has identified HRD as a biomarker for assessing the therapeutic response of tumor cells to poly(ADP-ribose) polymerase inhibitors and platinum-based chemotherapies. Nevertheless, the biology of HRD is complex, and its applications and the benefits of different HRD biomarker assays are controversial. This is primarily due to inconsistencies in HRD assessments and definitions (gene-level tests, genomic scars, mutational signatures, or a combination of these methods) and difficulties in assessing the contribution of each genomic event. Therefore, we aim to review the biological rationale and clinical evidence of HRD as a biomarker. This review provides a blueprint for the standardization and harmonization of HRD assessments.
Worldmaking at the End of History: The Gulf Crisis of 1990–91 and International Law
Authors: Aber Samuel L. 
Published: February 2023

AbstractThis Article argues that the Gulf Crisis of 1990–91, the first major international crisis of the post-Cold War era, was a constitutive moment for international law. The Article examines the contests in the United Nations over the meaning of the Crisis and shows that these contests were also over the meaning of cooperation under international law in the “new world order.” The Article casts the Gulf Crisis itself as a moment of “worldmaking,” in which the United States refashioned foundational concepts like interdependence, sovereignty, and humanity in warfare and deployed them to suit a state-centered vision of international cooperation under hierarchy.
Structural Elements and Requirements in Forming Prehospital Health Response Teams in Response to Chemical, Biological, Radiation, and Nuclear Incidents (CBRN), a Comparative Review Study
Authors: Nazari Saeed , Sharififar Simintaj , Ahmadi Marzaleh Milad , Zargar Sanaz , Azarmi Somayeh , Akbari Shahrestanaki Yusef 
Published: February 2023

Abstract
One of the important indicators of increasing the capacity of the health system and the chances of survival of patients and injured immediately after chemical, biological, radiation and nuclear (CBRN) accidents is rapid access to medical services. Establishing prehospital health response teams is one of the main strategies to improve the capacity and ability to respond to unusual events. The aim of this study was to investigate the factors influencing the formation of rapid response teams in the field of health in response to chemical, biological, radiation and nuclear accidents (CBRN EDMRT). In this study, the comparative review method was used. The study period was from November 1, 2021 to March 2022. Forming and deploying rapid health response teams based on an extensive multi-step search and keywords in multiple databases such as PubMed, CINHAL, Blackwell, Iranmedex, SID, Cochrane Database of Systematic Reviews, Google Scholar, Scopus Also, the websites of the Ministry of Health and the responsible organizations in different countries and the proposed structure were done by international institutions and sites. After accessing the resources and documents, the process of analysis and comparison of different team structures was performed. After the initial search, the structure and required elements of their teams were extracted. According to published articles and texts, 10 teams from the International Atomic Energy Agency (IAEA), the US Centers for Disease Control and Prevention (CDC), the US Department of Homeland Security, and the North Atlantic Treaty Organization (NATO), Australia, the British Public Health Organization, and the Japanese Red Cross were compared. Team requirements, population distribution, type of accident, level of team activity and training, equipment required by the team after the accident, according to which, each country/organization should consider the above factors to design and establish the structure of CBRN EDMRT to take. A study should be conducted to design a comprehensive and evidence-based structure.