bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling and identification of the hydration process in a CaO/Ca(OH)
2
-based heat storage system
Authors: Rentz Anja , Kühl Viktor , Sourmelis T Venizelos E. , Schmidt Matthias , Linder Marc , Sawodny Oliver , Böhm Michael 
Published: August 2023

Abstract
Thermochemical energy storage systems are promising for storing excess energy produced by renewable sources. Of particular interest and the focus of this paper is a specific application based on the reaction pair CaO and H2O. Working towards a model based controller for the reactor storage system, all of the ongoing processes need to be modeled. This publication establishes a model for the hydration process, where heat is recovered from the exothermic reaction of CaO and liquid H2O. The derivations are based on mass and enthalpy balance equations for the reactor and the cooling water. This yields a simple reactor system model, for which some parameters are unknown and need to be identified. For this, an optimization is set up. Additionally, the parameter sensitivity of the model outputs is analyzed. The simulation results with the identified parameters illustrate that the model is able to predict the measurements well. The sensitivity results coincide with the identification variance for the estimated parameters.
Intravaginal estrogen management in postmenopausal patients with vaginal squamous intraepithelial lesions along with CO2 laser ablation: A retrospective study
Authors: Lei Shengyao , Wu Congquan , Zhong Siyi , Liu Yanmei , Peng Ke , Han Xiao , Chen Jialing , Li Chunlan , Gao Shujun 
Published: August 2023

Abstract
This study aims to investigate the influence of topical estrogen management in postmenopausal patients who had undergone CO2 laser ablation for vaginal squamous intraepithelial lesions (SILs). The clinical data of 211 postmenopausal women with vaginal SILs were reviewed. Patients were divided into two groups by 2-month different management: Group 1 (intervention group): patients were treated with estrogen cream 0.5 g every other day and Group 2 (control group): no topical agent was used for the treatment of patients. In low-grade squamous intraepithelial lesions (LSILs), the response rates for patients in the intervention group and the control group were 49.1% (27/55) and 54.2% (16/48), respectively; human papillomavirus (HPV) status turned negative in 12 (12/38, 31.6%) patients of the intervention group and in 15 (15/35, 42.9%) patients of the control group. In high-grade squamous intraepithelial lesions (HSILs), the response rates for patients in the intervention group and the control group were 72.4% (42/58) and 78.0% (39/50), respectively, nearly 1.5 times higher than those of the LSIL patients; 22 (22/54, 40.7%) patients of the intervention groups and 12 (12/46, 26.1%) patients of the control group cleared the HPV infection. In postmenopausal patients, local use of estrogen cream improves the recognition of lesions and is conducive to precision medicine.
Metacognitive and metalinguistic activities can raise ELF awareness: why and how
Authors: Sifakis Nicos 
Published: August 2023

Abstract
Research shows that, while exposure to English as a lingua franca (ELF) discourse and to discussion of ELF-related interactional strategies – such as rephrasing, paraphrasing and translanguaging – can help raise English language teachers’ and learners’ ELF awareness, this is often not enough nor is the value of such exposure adequately monitored. In this paper, following the principles of ELF awareness (Sifakis, Nicos. 2019. ELF awareness in English language teaching: Processes and practices. Applied Linguistics 40(2). 288–306), I suggest that raising teachers’ and learners’ awareness of and attitudes towards their own experience as users of English inside and outside of the classroom needs to be prioritised, especially in Expanding Circle teaching and learning contexts. Together with this awareness, teachers and learners need to be made fully conscious of their deeper perceptions about key ELF concerns, such as the role of the native speaker in ELF interactions, the nature of intercultural communication, etc. Such awareness can be raised through metalinguistic and metacognitive activities and questions added to existing activities/materials. To this end, I propose a framework and a series of specific step-by-step scenarios and tools for raising teachers’ and learners’ ELF awareness along these lines and present four examples of integrating such metacognitive and metalinguistic activities with those of a specific textbook.
Risk factors of recurrent bacterial vaginosis among women of reproductive age: A cross-sectional study
Authors: Zeng Xianling , An Ruifang , Li Han 
Published: August 2023

Abstract
The aim of this study was to explore risk factors of recurrent bacterial vaginosis (RBV) among women of reproductive age. This cross-sectional study was carried out in real-world conditions. Women with RBV were selected, and simultaneously uncomplicated bacterial vaginosis (UBV) and those who underwent routine gynecological examination and had normal vaginal microflora were also recruited as the control. Totally, 316 participants were enrolled. Univariate analysis showed that unemployment, desserts, and wiping were related to UBV, while there was no definite relationship between education, high body mass index, smoking, sedentary lifestyle, and RBV or UBV. History of human papillomavirus infection, contraceptive methods, age at first sexual intercourse, and not cleaning vulva during sexual activity were connected with UBV, while the history of other vaginitis and number of sexual partners in the previous year were related to both RBV and UBV. Multivariate logistic regression analysis revealed that lower educational level increased the risk of suffering RBV. Interestingly, no smoking was a protective factor. Moreover, the absence of other vaginitis and an exclusive sexual partner could also weaken the risk of incurring RBV. These various adverse factors alter endocrine function and vaginal immunity, further leading to the recurrence of BV. It is necessary to take corresponding measures to avoid risk factors and to help lessening the prevalence of RBV among women of reproductive age.
Is it ‘
Sus
-picious’? Revisiting the Presence of the Wild Boar on the Island of Crete
Authors: Smíšek Michal , Molnárová Miriam 
Published: August 2023

Abstract
The presence of wild boar on the island of Crete has been discussed since the beginning of Cretan archaeology. Presumed wild individuals are depicted on various types of objects from the Minoan period. Wild pig remains have been identified on several Cretan sites ranging from the Neolithic to the Byzantine period. Despite the relatively large number of such reports, the nature of evidence from the island is often unclear or at least questionable. Available biometric data do not support the establishment of a stable wild population on the island during its history. This paper provides a detailed overview of contemporary evidence and highlights the need for systematic data collection.
Study of performance of low-rank nonnegative tensor factorization methods
Authors: Shcherbakova Elena M. , Matveev Sergey A. , Smirnov Alexander P. , Tyrtyshnikov Eugene E. 
Published: August 2023

Abstract
In the present paper we compare two different iterative approaches to constructing nonnegative tensor train and Tucker decompositions. The first approach is based on idea of alternating projections and randomized sketching for factorization of tensors with nonnegative elements. This approach can be useful for both TT and Tucker formats. The second approach consists of two stages. At the first stage we find the unconstrained tensor train decomposition for the target array. At the second stage we use this initial approximation in order to fix it within moderate number of operations and obtain the factorization with nonnegative factors either in tensor train or Tucker model. We study the performance of these methods for both synthetic data and hyper-spectral image and demonstrate the clear advantage of the latter technique in terms of computational time and wider range of possible applications.
Operator-difference schemes on non-uniform grids for second-order evolutionary equations
Authors: Vabishchevich Petr N. 
Published: August 2023

Abstract
The approximate solution of the Cauchy problem for second-order evolution equations is performed, first of all, using three-level time approximations. Such approximations are easily constructed and relatively uncomplicated to investigate when using uniform time grids. When solving applied problems numerically, we should focus on approximations with variable time steps. When using multilevel schemes on non-uniform grids, we should maintain accuracy by choosing appropriate approximations and ensuring stability of the approximate solution. In this paper, we construct unconditionally stable schemes of the first- and second-order accuracy on a non-uniform time grid for the approximate solution of the Cauchy problem for a second-order evolutionary equation. The novelty of the paper consists in the fact that these stability estimates are obtained without any restrictions on the magnitude of the step change and on the number of step changes. We use a special transformation of the original second-order differential-operator equation to a system of first-order equations. For the system of first-order equations, we apply standard two-level time approximations. We obtained stability estimates for the initial data and the right-hand side in finite-dimensional Hilbert space. Eliminating auxiliary variables leads to three-level schemes for the initial second-order evolution equation. Numerical experiments were performed for the test problem for a one-dimensional in space bi-parabolic equation. The accuracy and stability properties of the constructed schemes are demonstrated on non-uniform grids with randomly varying grid steps.
Gingival status and prophylactic oral hygiene measures modulate salivary amino acids’ profile in children with plaque-induced gingivitis
Authors: Galunska Bistra Tzaneva , Salim Ayshe Seyhan , Nikolova Miglena Nikolaeva , Angelova Sirma Todorova , Kiselova-Kaneva Yoana Dimitrova , Peev Stefan Vasilev , Ivanova Diana Georgieva 
Published: August 2023

Abstract

Objectives
Plaque-induced gingivitis is one of the most widely distributed periodontal disorder during childhood. The control of the pathogenic potential of the plaque is associated with oral hygiene status at individual, group, and population levels. We hypothesize that regular application of complex oral hygiene-prophylaxis could beneficially modulate salivary amino acids profile in children with different stage of plaque-induced gingivitis. Therefore, we aimed to study the salivary amino acids’ profile in relation to certain clinical indicators and environmental variables for plaque-induced gingivitis in children.

Methods
Fifty children (29 girls, 21 boys; mean age 8.18 ± 2.32 years) without anamnestic data for common diseases, no medication, and no data for allergy were selected. Plaque and gingival indexes were determined for assessment oral hygiene and plaque accumulation. Unstimulated whole saliva was collected, centrifuged and supernatants stored at −80 °C. Amino acid analysis was performed by liquid chromatography using analytical grade AccQ·Tag-Ultra-derivatization kit.

Results
Gingivitis was indicated in most of the examined children over 6 years. More than half (63.6 %) of them revealed moderate stage of the disease and a tendency to satisfactory good oral hygiene and degree of gingival inflammation. Salivary glycine, proline, arginine, serine, lysine, aspartate, glutamate, threonine, methionine, and isoleucine were higher in gingivitis children, while cysteine, tyrosine and phenylalanine decrease. In gingivitis children without regular oral hygiene-prophylaxis, some structural amino acids like glycine and proline were increased, while amino acids with protective antioxidant potential like cysteine were diminished.

Conclusions
Plaque-induced gingivitis is associated with increased salivary levels of certain amino acids. These may serve as distinguishing markers among children with gingivitis.
From Halo to Conditioning and Back Again: Exploring the Links Between Impression Formation and Learning
Authors: Rougier Marine , De Houwer Jan , Richetin Juliette , Hughes Sean , Perugini Marco 
Published: August 2023

Impression formation effects – such as the halo effect – and learning effects – such as evaluative or attribute conditioning effects – are often seen as separate classes of phenomena. In a recent conceptual paper, De Houwer et al. (2019) suggested that both may actually qualify as instances of feature transformation, where a source feature (e.g., attractiveness of a face; valence of an unconditioned stimulus; US) influences judgements about a target feature (e.g., social competence of a person; valence of a conditioned stimulus; CS). In halo effects, the source and target features typically differ (e.g., a person with an attractive face is judged as more socially competent) but belong to the same object. In evaluative conditioning, source and target features are the same (e.g., a neutral CS is judged as more positive after being paired with a positive US) but belong to different objects. In this paper, we highlight a phenomenon at the crossroads of the two previous effects: feature transformation where source and target features are different (as in halo studies) and belong to different objects that are paired together (as in evaluative conditioning studies). Across six pre-registered experiments (n = 1050), we obtained evidence for this phenomenon in the context of person perception (i.e., attractiveness halo) and food perception (i.e., health halo). We also show that this type of feature transformation is influenced by several known moderators of halo and conditioning effects (beliefs about traits relationship, memory of pairings, and salience of the source feature).
NT-proBNP as a neuroendocrine tumor biomarker: beyond heart failure
Authors: Komarnicki Paweł , Gut Paweł , Musiałkiewicz Jan , Cieślewicz Maja , Maciejewski Adam , Patel Prachi , Mastorakos George , Ruchała Marek 
Published: August 2023

Introduction
Neuroendocrine tumors (NETs) are rare neoplasms that occur in various locations throughout the body. Despite their usually benign character, they might manifest with distant metastases. N-terminal prohormone of brain natriuretic peptide (NT-proBNP) has previously been described as a useful biomarker in diagnosing carcinoid heart disease (CHD), a common advanced NETs manifestation. We observed plasma concentrations of NT-proBNP in metastatic midgut NETs over a 4-year period.

Objectives
We aimed to explore NT-proBNP concentrations in states of varying levels of cell proliferation and disease status. Our goal was to investigate NT-proBNP’s role in predicting disease progression in relation to previous research and up-to-date scientific guidelines.

Patients and methods
We performed a retrospective multivariate analysis of NT-proBNP concentrations in 41 midgut NETs patients treated with somatostatin analogs, all with liver metastases. NT-proBNP concentrations were measured in every patient across 16 evenly distanced time points over a 48-month period and were compared to variables such as sex, age, grading, Ki-67, primary tumor location, and CT findings.

Results
NT-proBNP concentrations correlated positively with higher liver tumor burden, higher grading, high Ki-67 levels, and with progressive disease in CT. There were no differences in NT-proBNP levels with regard to primary location (ileum vs jejunum), sex, and age.

Conclusion
We conclude that NT-proBNP is a useful analyte for monitoring NETs progression, due to its increased concentration in scenarios implying increased cellular proliferation. These long-term follow-up results align with previous findings and suggest an additional role for NT-proBNP in diagnostic algorithms, beyond a CHD biomarker.
ASSOCIATION BETWEEN SYSTEMIC IMMUNEINFLAMMATION INDEX AND MORTALITY IN PATIENTS WITH NON-ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: ÇAYIRLI Sercan , RAHMAN Ömer Faruk , MUTLU Berk , GÜLAŞTI Sevil 
Published: August 2023

Objective
Acute coronary syndrome (ACS) is a disease associated
with high mortality and morbidity. It is essential to
identify high-risk patients during hospitalization and
to implement early revascularization strategies if
necessary. There is a clear need for a simple, effective
and cost-effective index for rapid identification of these
patients in clinical practice. The aim of this study was
to investigate the clinical significance of the systemic
immune inflammation index (SII) in non-ST-segment
elevation myocardial infarction (NSTEMI), a subgroup
of ACS, and to evaluate its association with mortality.
Material and Method
Patients who underwent coronary angiography at the
Coronary Angiography Unit of Aydın Adnan Menderes
University Faculty of Medicine Research and Training
Hospital between January and December 2022 were
retrospectively reviewed. Individuals with a diagnosis
of NSTEMI were included as group I, and individuals
with normal coronary arteries during coronary
angiography were included as group II (control group).
Clinical variables and calculated SII values of the
groups were recorded. The role of SII in predicting
all-cause mortality and its effect on expected survival
were evaluated.
Results
The median value of the SII index was significantly
higher in the NSTEMI group (group I) than in the control
group (group II) (p
Hospitalizações por COVID-19 no Brasil: características sociodemográficas, fatores de risco e manifestações clínicas
Authors: Ceccon Roger Flores , Alberto Severo Garcia Júnior Carlos , Perondi Fabiane , Oliveira Marx Letícia , André Prange da Silva Luiz , Eduarda Coelho Cordeiro Maria , Galatto Cancillier Sarah , Madeira Kristian 
Published: August 2023

Objetivo: Comparar as características sociodemográficas, os fatores de risco e as manifestações clínicas da COVID-19 em pessoas hospitalizadas no Brasil entre os anos de 2020 e 2021. Métodos: Estudo transversal cuja amostra foi de 1.150.041 pessoas hospitalizadas. A análise estatística foi realizada por meio do teste U de Mann-Whitney e Qui-quadrado de Pearson. Resultados: Em 2020, as hospitalizações estiveram associadas ao sexo masculino, cardiopatia, diabetes, doença renal, tosse e febre (p<0,001). Em 2021, cor da pele branca, obesidade e síndrome de down foram fatores associados à hospitalização, cujos sintomas envolveram dispneia, saturação de O2 <95% e desconforto respiratório, com maior proporção de óbitos (p<0,001). Internação em UTI não apresentou diferença estatisticamente significativa. Conclusões: A hospitalização por COVID-19 no Brasil apresentou elevada frequência. No primeiro ano atingiu pessoas com mais idade e que apresentavam comorbidades prévias, e em 2021 se caracterizou pela acentuada carga de sintomas e maior gravidade clínica.
Can Triglyceride/Glucose Index (TyG) and Triglyceride/HDL-Cholesterol Ratio (TG/HDL-c) Predict Gestational Diabetes Mellitus?
Authors: YILMAZ ERGANİ Seval , İLHAN Tolgay Tuyan , TOKGÖZ Betül , BAYRAKTAR Burak , BUCAK Mevlüt , İBANOĞLU Müjde Can , YAKUT YÜCEL Kadriye , ERDOĞAN Kadriye , İSKENDER Cantekin , ÜSTÜN Yaprak 
Published: August 2023

AIM: We investigated whether measurement of triglyceride/glucose index (TyG) and triglyceride/HDL-cholesterol ratio (TG /HDL-c) in the first trimester can predict gestational diabetes mellitus (GDM).
MATERIAL AND METHOD: Twenty-five patients with GDM and 52 women without GDM with normal glycemic control during pregnancy were included in the study as a control group. Both insulin-controlled diabetes and diet-controlled diabetes were included in the diagnosis of GDM. Fasting glucose and plasma lipid profiles including TG, HDL-c, TyG index, and TG /HDL-c measured in the first trimester were analyzed.
RESULTS: Triglyceride values (mean 133±40 mg/dL in the gestational diabetes group, 100±54 mg/dL in the control group), TyG index (15.0±8.9 in the mean gestational diabetes group, 8.8±5.0 in the control group), and TG/HDL-C ratio (mean 3.3±2.6 in the gestational diabetes group and 1.9±2.6 in the control group) was found to be significantly higher in the GDM group (p=0.01, p=0.01, p=0.01, respectively). The optimal cutoff value for TyG index was 10.4, sensitivity was 76%, specificity was 77%, and area under the receiver characteristic curve (AUC) was 0.765 to predict GDM (p < 0.001). The optimal cutoff value for the TG /HDL-C ratio was 2.3, sensitivity was 76%, specificity was 69, AUC 0.697 to predict GDM (p=0.005).
CONCLUSION: TyG and TG/HDL-C ratio measured in the first trimester are thought to predict GDM better than fasting plasma glucose.
Hepato-Renal Protective Potential of Dimethyl Fumarate in Alloxan-Induced Diabetic Mice Model by Modulating of Sirt1, Nrf2 and Inflammatory Genes Expressions
Authors: Saberi Hasanabadi Parisa , Shaki Fatemeh , Karami Mohammad , Bagheri Abouzar , Ranaee Mohammad , Ataee Ramin 
Published: August 2023

Background: Despite advances in diabetes-related treatments, the effects of the disease have not yet been adequately reversed or prevented in patients. Therefore, there is an urgent need to develop more effective medication-assisted treatments in this field.
Methods: In this study, type 1 diabetes mice models was established using multiple low-dose alloxan, and the diabetic mice were treated with three doses of dimethyl fumarate (DMF) i.e low, medium, and high viz. 20, 40 and 80 mg/kg, respectively for a period of 21 days. Then, specific test were done to evaluate blood biochemical parameters, oxidative stress markers, inflammatory genes expression, and histopathological changes in the mice kidney and liver.
Results: The obtained results showed remarkably improved anti-diabetic, hepato-renal-protective, and oxidative stress indexes of DMF in alloxan-induced diabetic mice (p&lt; 0.001). Treated mice with DMF demonstrated a noteworthy decrease in blood glucose levels when compared with diabetic group (p&lt; 0.001). Diabetic liver and kidney tissues showed marked dilation of bile ducts, tubules, infiltration, and inflammation. On the contrary, the histological features of the treated mice with DMF improve as shown by normal size of glomerular capillaries along with decrease in less dilatation of ducts in comparison with diabetic mice. The real-time quantitative PCR results indicated that DMF injection decreased the alloxan-induced increase of significant elevations in mRNA levels of pro-inflammatory cytokines and adhesion molecules such as TNF-α, IL-6, and NF-κB levels in both kidney and liver tissues. Meanwhile, mice treated with DMF showed an increase in Sirt1 and Nrf2 expression in comparison to diabetic group.
Conclusion: In conclusion, it can be concluded that DMF treatment provides hepato-renal protective effects on alloxan-induced diabetic mice model by attenuating ROS inflammatory pathways.
Keywords: Diabetes, Dimethyl fumarate, Alloxan, Anti-inflammatory responses, Hepato-renal-protective effects.