bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of slope deterioration mechanism under freeze–thaw cycles: centrifuge modelling
Authors: Ng Charles W.W. , Wang Yikai , Zhang Shuai , Li Zeyu , Zhang Qi , Zhong Haiyi 
Published: March 2023

Although deterioration of soil due to freeze–thaw cycles has been investigated based on element tests and small-scale laboratory model tests, there still lacks fundamental understanding of slope response under cyclic freeze–thaw action. In this study, a novel in-flight freeze–thaw system was developed to investigate the thermal, hydraulic and mechanical response of a typical unsaturated slope under seven freeze–thaw cycles in the centrifuge. Temperature, suction and deformation were measured during the test. The test results show that the suction at the freezing front can be up to about 1 MPa. The comparison between measured and theoretically predicted suction elucidates that using the temperature-dependent Clausius–Clapeyron equation is inadequate to model suction evolution precisely when considering water migration. The subsequent thawing reduces the suction to 9 kPa, which is about 60% lower than during the initial unfrozen state. The suction destruction softens the surface soil layer, leading to downslope movement during thawing. During the seasonal downward ratcheting movement, the lower elevation of the slope can flatten from 59° to 50°. The repeated freeze–thaw action generates significant fractures at the soil surface while deep cracks can form due to tensile rupture. Freeze–thaw-induced seasonal variation of suction softens the post-thawed slope, leading to accumulated plastic deformation and shallow slope failure.
The tectonic evolution of Thelon tectonic zone, Canada: a new model based on petrological modeling linked with Lu–Hf garnet and U–Pb accessory mineral geochronology
Authors: Berman Robert G. , Cutts Jamie A. , Davis William J. , Camacho Alfredo , Sanborn-Barrie Mary , Smit Matthijs A. 
Published: March 2023

Petrological modeling and geochronology (Lu–Hf garnet, U–Pb monazite, zircon, and titanite) for seven mid-amphibolite to granulite-facies metamorphic rocks in the Thelon tectonic zone (Ttz) provide new insights into the evolution of this orogen. A Grt-Sp-Sil diatexite records 2.01–2.00 Ga garnet and monazite growth during >830 °C contact metamorphism associated with voluminous convergent margin plutonism. The most widespread, 1.96–1.90 Ga metamorphism is associated with clockwise pressure ( P)–temperature ( T) paths, indicating it was driven by crustal thickening. Earlier (1.96–1.92 Ga) and lower temperature (630 °C–730 °C; 6–8 kbar) metamorphism in the eastern Slave craton contrast with ∼860 °C (7.5 kbar), 1.91–1.90 Ga diatexites in the central, Paleoproterozoic plutonic rock-dominated, core of the Ttz. These differences are interpreted to reflect lower vs. upper plate settings, respectively. A contribution of mantle heat is suggested by the counter-clockwise P–T path and 885 °C (5.7 kbar) conditions recorded by diatexite associated with c. 1.9 Ga peraluminous leucogranite that dominates a corridor along the Ttz–Rae craton boundary. A tectonic model is proposed wherein the Ttz evolved at an accretionary margin after rifting of Ttz microcontinent (mTtz) off the Rae craton at c. 2.2–2.1 Ga. Voluminous plutonism at 2.01–1.98 Ga formed via east-dipping subduction under mTtz. Following 1.97 Ga collision of the Slave craton and mTtz, west-dipping subduction generated 1.96–1.95 Ga plutonism in the composite mTtz-Slave upper plate. Collision of Rae craton at 1.95–1.94 Ga led to crustal thickening, widespread 1.91–1.90 Ga high-grade metamorphism and extensive crustal melting in the central Ttz.
Neonatal treatment with fluoxetine alters locomotor activity and the cortical glial/neuron index in rats with cerebral palsy
Authors: de Albuquerque Glayciele Leandro , Manhães-de-Castro Raul , Lacerda Diego Cabral , Calado Caio Matheus Santos da Silva , Bezerra de Morais André Teracio , Visco Diego Bulcão , Manhães-de-Castro Francisco Machado , Toscano Ana Elisa 
Published: March 2023

Cerebral palsy (CP) is characterized by motor disorders, including deficits in locomotor activity, coordination, and balance. Selective serotonin reuptake inhibitors have been shown to play an important role in brain plasticity. This study investigates the effect of neonatal treatment using fluoxetine on locomotor activity and histomorphometric parameters of the primary somatosensory cortex (S1) in rats submitted to an experimental model of CP. CP was found to reduce bodyweight and locomotion parameters and also to increase the glia/neuron index in the S1. Administration of fluoxetine 10 mg/kg reduced bodyweight, impaired locomotor activity parameters, and increased the number of glial cells and the glia/neuron ratio in the S1 in rats with CP. However, treatment with fluoxetine 5 mg/kg was not found to be associated with adverse effects on locomotor activity and seems to improve histomorphometric parameters by way of minor changes in the S1 in animals with CP. These results thus indicate that experimental CP, in combination with the use of a high dose of fluoxetine (10 mg/kg), impairs locomotor and histomorphometric parameters in the S1, while treatment with a low dose of fluoxetine (5 mg/kg) averts the negative outcomes associated with a high dose of fluoxetine in relation to these parameters but produces no protective effect.
GRASIAN: towards the first demonstration of gravitational quantum states of atoms with a cryogenic hydrogen beam
Authors: Killian Carina , Burkley Zakary , Blumer Philipp , Crivelli Paolo , Gustafsson Fredrik P. , Hanski Otto , Nanda Amit , Nez François , Nesvizhevsky Valery , Reynaud Serge , Schreiner Katharina , Simon Martin , Vasiliev Sergey , Widmann Eberhard , Yzombard Pauline 
Published: March 2023

Abstract
At very low energies, a light neutral particle above a horizontal surface can experience quantum reflection. The quantum reflection holds the particle against gravity and leads to gravitational quantum states (gqs). So far, gqs were only observed with neutrons as pioneered by Nesvizhevsky and his collaborators at ill. However, the existence of gqs is predicted also for atoms. The Grasian collaboration pursues the first observation and studies of gqs of atomic hydrogen. We propose to use atoms in order to exploit the fact that orders of magnitude larger fluxes compared to those of neutrons are available. Moreover, recently the q-Bounce collaboration, performing gqs spectroscopy with neutrons, reported a discrepancy between theoretical calculations and experiment which deserves further investigations. For this purpose, we set up a cryogenic hydrogen beam at 6 $$\hbox {K}$$
K
. We report on our preliminary results, characterizing the hydrogen beam with pulsed laser ionization diagnostics at 243 $$\hbox {nm}$$
nm
.

Graphical abstract
A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
Authors: Huang Xinmei , Zhang Shenghua , Tang Jingshu , Tian Tian , Pan Yilin , Wu Lina , Zhang Jingxuan , Liu Yang , Huang Jing , Dai Hui , Xu Weiyan , Zhang Youhui , Chen Jinfeng , Cao Mengshu , Zhang Liang , Qiu Xiaoyan 
Published: March 2023

AbstractElevated IgG expression in cancer cells has been implicated in exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating the need for a better understanding of the regulatory mechanisms that control the expression and function of sialylated cancer IgG (SIA-cIgG). Here, we conducted genome-wide CRISPR activation screening and identified OCT4 and SOX2 as the key factors that promote SIA-cIgG expression. Functional investigation revealed that SIA-cIgG reciprocally stimulated SOX2 by activating the c-Met/Akt/Erk signaling axis, constituting a self-propagating loop of SIA-cIgG/c-Met/SOX2/SIA-cIgG signaling. This signaling loop was highly active in stem-like cells from many epithelial cancers and was crucial for cancer stemness in vitro and in vivo. Notably, the mAb RP215, which specifically recognizes the Asn162 sialylation–related epitope on SIA-cIgG, effectively blocked the SIA-cIgG–driven signaling loop. Furthermore, RP215 significantly inhibited lung cancer cell stemness and tumor growth in a patient-derived xenograft model. In conclusion, these findings revealed a self-propagating c-Met/SOX2/SIA-cIgG signaling loop that promotes cancer stemness, identifying novel therapeutic strategies for cancer treatment.Significance:Sialylated cancer IgG activates c-Met-SOX2 signaling to promote stemness properties in cancer cells and can be targeted to suppress tumor growth.
Clonal Spreading of Tumor-Infiltrating T Cells Underlies the Robust Antitumor Immune Responses
Authors: Aoki Hiroyasu , Tsunoda Mikiya , Ogiwara Haru , Shimizu Haruka , Abe Haruka , Ogawa Tatsuro , Abe Takaya , Shichino Shigeyuki , Matsushima Kouji , Ueha Satoshi 
Published: March 2023

Abstract

The repertoire of tumor-infiltrating T cells is an emerging method for characterizing effective antitumor T-cell responses. Oligoclonal expansion of the tumor T-cell repertoire has been evaluated; however, their association with antitumor effects is unclear. We demonstrate here that the polyclonal fraction of the tumor-reactive T-cell repertoire, consisting of relatively minor clones, increased in tumor-bearing mice treated with monoclonal anti–programmed death-ligand 1 (PD-L1) or anti-CD4, which correlated with antitumor effects. Meanwhile, the size of the oligoclonal fraction consisting of major clones remained unchanged. Moreover, the polyclonal fraction was enriched in progenitor exhausted T cells, which are essential for a durable antitumor response, and was more dependent on CCR7+ migratory dendritic cells, which are responsible for priming tumor-reactive T cells in the tumor-draining lymph nodes. These results suggest that the expansion of diverse tumor-reactive clones (“clonal spreading”) represents characteristics of antitumor T-cell responses induced by anti-CD4 and anti–PD-L1 treatment.
Associations of Urine Biomarkers of Kidney Tubule Health With Incident Hypertension and Longitudinal Blood Pressure Change in Middle-Aged Adults: The CARDIA Study
Authors: Khan Muhammad B. , Scherzer Rebecca , Lewis Cora E. , Malhotra Rakesh , Ix Joachim H. , Shlipak Michael G. , Gutiérrez Orlando M. 
Published: March 2023

Background:
Urine biomarkers of kidney tubule injury associate with incident hypertension in older adults with comorbidities, but less is known about these associations in younger adults.

Methods:
In 1170 participants of the CARDIA study (Coronary Artery Risk Development in Young Adults; mean age, 45 years; 40% Black people; 56% women) without hypertension, cardiovascular disease, or kidney disease at baseline, we examined associations of urine MCP-1 (monocyte chemoattractant protein-1), α1m (alpha-1-microglobulin), KIM-1 (kidney injury molecule-1), EGF (epidermal growth factor), IL (interleukin)-18, YKL-40 (chitinase-3-like protein 1), and UMOD (uromodulin) with incident hypertension (onset of systolic blood pressure [BP] ≥130 mm Hg or diastolic BP ≥80 mm Hg or initiation of hypertension medications) and longitudinal BP change in models adjusted for hypertension risk factors, estimated glomerular filtration rate, and albuminuria.

Results:
After a median 9.9 (interquartile range, 5.9–10.2) years, 376 participants developed incident hypertension. In demographic-adjusted analyses, higher tertiles of EGF associated with lower risk of incident hypertension in both Black and White participants. After multivariable adjustment, the risk of incident hypertension remained lower in tertile 2 (hazard ratio, 0.70 [95% CI, 0.50–0.97]) and tertile 3 (hazard ratio, 0.58 [0.39–0.85]) of EGF versus tertile 1. In fully adjusted models, participants in EGF tertile 3 had smaller 10-year increases in systolic (−3.4 [95% CI, −6.1 to −0.7] mm Hg) and diastolic BP (−2.6 [95% CI, −4.6 to −0.6] mm Hg) than tertile 1. Other biomarkers showed inconsistent associations with incident hypertension and BP change.

Conclusions:
In middle-aged adults without hypertension, cardiovascular disease, or kidney disease, higher urine EGF associated with lower risk of incident hypertension and lower 10-year BP elevations.
Testing for Salience Effects in Choices under Risk
Authors: Nielsen Carsten S. , Sebald Alexander C. , Sørensen Peter N. 
Published: March 2023

Abstract
We construct and run an experiment to test the most basic choice effect predicted by Salience Theory. Subjects allocate wealth between a risky and a safe investment. While we vary an apparent payoff ratio to influence salience, treatments have economically equivalent consequences. Most other theories of behavior then predict zero effect. Our experimental findings are strongly consistent with the behavioral implication of a continuous version of Salience Theory. We provide a novel structural estimate on the strength of salience. In our setting, increasing the relative payoff contrast by one percent is equivalent to an increased odds ratio by about 0.4 percent.
The Need for Speed: Demand, Regulation, and Welfare on the Margin of Alternative Financial Services
Authors: McDevitt Ryan C. , Sojourner Aaron 
Published: March 2023

Abstract
We use a nonlinear reduction in a bank's check-cashing fees and variation in regulated check-clearing times to identify the elasticity of demand for cashing checks rather than depositing them. We find that an extra day of check-clearing time makes account holders 65.5% more likely to cash a check than deposit it, which implies they are willing to pay $11.17 per day for faster access to their funds – an effective annualized discount rate of 11,054% for the average check. We use this elasticity to evaluate recent proposals that mandate faster check-clearing times.
Risk Perceptions and Private Protective Behaviors: Evidence from COVID-19 Pandemic
Authors: Bundorf M. Kate , DeMatteis Jill , Miller Grant , Polyakova Maria , Streeter Jialu L. , Wivagg Jonathan 
Published: March 2023

Abstract
We analyze data from a survey we administered during the COVID19 pandemic to investigate the relationship between people's subjective beliefs about risks and their private protective behaviors. On average, people substantially overestimate the absolute level of risk associated with economic activity, but have directionally correct signals about their relative risk based on their demographic characteristics. Subjective risk beliefs are predictive of changes in economic activities independently of government policies. Government mandates restricting economic behavior, in turn, attenuate the relationship between subjective risk beliefs and protective behaviors.
Job-to-Job Mobility and Inflation
Authors: Faccini Renato , Melosi Leonardo 
Published: March 2023

Abstract
The low rate of inflation observed in the U.S. over the past decade is hard to reconcile with traditional measures of labor market slack. We develop a theory-based indicator of interfirm-wage competition that can explain the missing inflation. Key to this result is a drop in the rate of on-the-job search, which lowers the intensity of interfirm-wage competition to retain or hire workers. We estimate the on-the-job search rate from aggregate labor-market flows and show that its recent drop is corroborated by survey data. During “the great resignation”, interfirm-wage competition rose, raising inflation by around 1 percentage point in 2021.
Wealth-Income Ratios in Free Market Capitalism: Switzerland, 1900-2020
Authors: Baselgia Enea , Martínez Isabel Z. 
Published: March 2023

Abstract
We show that over the 20th century, in Switzerland the ratio of private wealth to national income, βpt, did not follow a U-shaped pattern, thereby contrasting the evolution in most European countries. Instead, the ratio was exceptionally stable at around 500%. We argue that this consistently high βpt was the result of geopolitical factors combined with Switzerland's capital friendly policy-making. Since the turn of the century, however, βpt has been on a rapid rise to reach 793% in 2020. This exceptionally fast increase is mainly driven by large capital gains, especially in housing wealth.
Challenging Encounters and Within-Physician Practice Variability
Authors: Chodick Gabriel , Goldstein Yoav , Shurtz Ity , Zeltzer Dan 
Published: March 2023

Abstract
We examine how physician decisions are impacted by difficult cases—encounters with newly diagnosed cancer patients. Using detailed administrative data, we compare primary care physicians' decisions in visits that occurred before and after difficult cases and matched comparison cases by the same physicians on other dates. Immediately following a difficult case, physicians increase referrals for common tests, including diagnostic tests unrelated to cancer. The effect lasts only for about an hour and is not driven by patient selection or schedule disruption. The results highlight difficult encounters as a source of variability in physician practice.
On the Restoration of Job: Poetics and Meaning in Job 42
Authors: Berger Yitzhak 
Published: March 2023

Abstract
The epilogue of Job, for no immediately obvious reason, links the restoration of Job’s wealth to his prayer on behalf of his friends. In doing so, it deploys a formulation that features redundancy and multiple philological irregularities. These compositional choices serve several objectives. Particularly on the assumption that Job, in his final speech, maintains an abidingly defiant posture toward God, his prayer constitutes a prerequisite for his restoration. Indeed, in subtle ways, the text emphasizes the prayer’s pivotal role. The text’s odd formulation, for its part, generates inner-biblical parallels that contribute to meaning. One parallel invokes a wider correlation to the Joseph story, implying that Job, in contrast to the victimized Joseph, must extend forbearance to his offenders before regaining wealth and stature. Another parallel helps intimate that Job recovered from his malady, a development that the text, because of an understandable concern, does not wish to state explicitly.
A (Somewhat) New Way to See and Understand the Diverse and Strategic Use of the Interrogatives in Isa 40:12–31
Authors: Adams Jim W. 
Published: March 2023

Abstract
Interpreters predominantly identify the interrogatives in Isa 40:12–31 as Rhetorical Questions (RQs) along with a single Genuine Question. However, upon closer examination the prophet also employs another type of interrogative that operates similarly to RQs, namely Conducive Questions. The prophet creatively and strategically arranges the interrogatives into a parallel pattern. Specifically, the prophet forms two parallel interrogative sequences with each placed in two respective parallel literary sequences (vv. 12–20; 21–26) that together constitute the first section of vv. 12–31. A second literary unit (vv. 27–31) begins with a Genuine Question immediately followed by a final pair of interrogatives. The prophet utilizes the Conducive and Rhetorical Questions to intentionally lead the addressee to verbally confirm, mentally assent to, and, in certain instances, confess with the inferred answers. The prophet’s purpose with these interrogatives aims at synchronizing the theological worldviews of both communicative participants.
Nochmals zur Frühdatierung von Ri 19*
Authors: Stipp Hermann-Josef 
Published: March 2023

Abstract
The essay substantiates an older thesis, according to which the so-called narrative of the outrage in Gibeah (Judg 19*) was written in circles around David as a propagandistic pamphlet, with the intention to win over the northern tribes to Jerusalem’s claim to power and to rally them against a competing claim from Benjamin. To this end, the study expands the list of observations that indicate that Judg 19* originated as an independent text, discusses questions of text-internal values of Judg 19–21, lays out further implications of the proposed dating, and critically examines recent studies on this complex.
“The Scythians Do Still Scare Us”
Authors: Cadili Luca 
Published: March 2023

Abstract
In Col 3:11, through tightly contrasting couplets, we are told that everyone can enjoy God’s grace. Though the passage seemingly involves no difficulty, doubts may be raised about the opposition between barbarians and Scythians, both being uncivilized nations. Yet the savagery of the latter, unparalleled among the barbarians, was their well-known hallmark. Even though this picture of the Scythians seems to have become commonplace in Greek and Roman literature, it might be inferred from epigraphical evidence that this barbarian nation was still a reason for disquiet in Asia Minor at the time when the Letter to the Colossians was delivered.
A Farewell to the Pondering Mary
Authors: Hoogerwerf Cornelis 
Published: March 2023

Abstract
Almost sixty years ago, W.C. van Unnik demonstrated that the participle συµβάλλουσα in Luke 2:19 does not mean “pondering” but that Mary was “understanding” the heavenly message. The limited reception of his view, especially in anglophone literature and translations of the Bible, stems from misconceptions about the lexical definition and the imperfective aspect of συµβάλλουσα, as well as from a problematic interpretation of the phrase “to keep matters/words in one’s heart.” The present study proposes that Luke 2:19 means that Mary preserved the message as revealed knowledge of the future and understood its meaning. This interpretation makes better sense within the infancy narrative and the Gospel of Luke as a whole than traditional interpretations and sheds new light on Mary’s image and function.
Portuguese Mercenary Networks in Seventeenth-Century India: An Experiment in Global Microhistory and its Archive
Authors: Marcocci Giuseppe 
Published: March 2023

Abstract
Thousands of runaways left the Portuguese empire during the early modern period, but very little is known about the lived experience of this diverse group of individuals after they fled. This article questions the framework of analysis that reduces such a complex social phenomenon to the overarching category of “informal empire,” while testing the hypothesis that the issue of the archive lies at the core of the practice of global microhistory. A set of primary sources in Portuguese, Dutch, English, Marathi, and Persian is analyzed at close range to reconstruct the choices, motivations, and hesitations of a specific group of “Portuguese” – mostly dark-skinned mestiços of modest origin – who served as mercenaries in north-western Deccan. I argue that studying the networks of these mercenaries ultimately reveals localized forms of endurance and adaptation to rapid and disruptive changes brought about locally by imperial rivalry and long-distance commerce.
The Slave and the Scholar: Representing Africa in the World from Early Modern Tripoli to Borno (N. Nigeria)
Authors: Dewière Rémi 
Published: March 2023

Abstract
The Borno sultanate in present-day Nigeria was an early modern Islamic state at the crossroads of regional, transregional, and global networks. Sahelian pilgrims, North African scholars, European slaves, Saharan nomads, and Turkish mercenaries would travel to its capital, connecting it with West Africa, the Mediterranean World, and the Middle East. How do we assess Borno’s integration in the global early modern world from a plural perspective, both from the inside and the outside? Using the narratives of Aḥmad b. Furṭū, a sixteenth century Borno scholar living in the sultan’s court, and of Pierre Girard, a French slave in seventeenth century Tripoli, Libya, I will interrogate the idea of globality from a Borno-centered representation of the world. The mental mapping of these narratives raises a yet unanswered question in the field of early modern history: How can we conceive global history from an African point of view?