bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on foreign language learning, teaching, and assessment in Sweden 2012–2021
Authors: Bardel Camilla , Gyllstad Henrik , Tholin Jörgen 
Published: March 2023

AbstractThis review provides an account of salient research topics in current Swedish research in the field of foreign language (FL) education, with the aim of making locally published work available outside Sweden. A corpus of work on English and other FLs published between 2012 and 2021 has been scrutinized. Focus has been placed on research conducted and disseminated in Sweden, in some cases adding international publications, in order to portray the work in a wider context. Research on FL learning, teaching, and assessment is reviewed in light of recent policy changes as well as a changing linguistic situation characterized by a plethora of languages spoken in society, among which Swedish as majority language and English as lingua franca share indisputable sovereignty, but where a newly-born interest in the role of other background languages than Swedish can be discerned. The study ends with a discussion of trends observed in the reviewed material and considerations in view of future research.
Terrorist Attacks against Health Care Targets that Provide Abortion Services
Authors: Wirken Bart , Barten Dennis G. , De Cauwer Harald , Mortelmans Luc , Tin Derrick , Ciottone Gregory 
Published: March 2023

AbstractIntroduction:Terrorist attacks against hospitals and health care providers have disproportionally increased during the last decades. A significant proportion of these attacks targeted abortion clinics and abortion providers. In the light of the overturning of Roe v. Wade in 2022, an increase of anti-abortion terrorist attacks is anticipated. Therefore, it becomes imperative to gain further insight into the risk and characteristics of past terrorist attacks. This study aimed to review terrorist attacks against health care targets providing abortion services from 1970 through 2020.Methods:Data collection was performed using a retrospective database search through the Global Terrorism Database (GTD). The GTD was searched using the internal database functions for all terrorist attacks against abortion health care providers from January 1, 1970 - December 31, 2020. Temporal factors, location, attack and weapon type, and number of casualties or hostages were analyzed using descriptive statistics.Results:In total, 262 terrorist attacks were identified in five different countries. The majority (96.6%) occurred in the United States, with the highest counts during the last 20 years of the 20th century. Facility and infrastructure attacks were the most common attack types, followed by bombings and explosions. The attacks resulted in 34 injuries and nine fatalities. Kidnapping took place in three incidents. Of all successful attacks, 96.9% resulted in property damage.Conclusion:Abortion-related health care facilities and providers have repeatedly been the target of terrorists over the past decades. Nearly all of these attacks took place in the United States, with the highest counts during the last 20 years of the 20th century.
Local Candidate Roots and Electoral Advantages in US State Legislatures
Authors: Hunt Charles Russell , Rouse Stella 
Published: March 2023

AbstractA growing literature has revealed a notable electoral advantage for congressional and gubernatorial candidates with deep local roots in their home districts or states. However, there is a dearth of research on the presence and impact of local roots in state legislative races. In this paper, we close that gap by demonstrating the consistent and significant electoral impacts that state legislators’ local roots have on their reelection efforts. We use data capturing a representative cross-section of state legislative incumbents (N = ~5,000) and calculate a novel index measuring the depth of their local roots modeled after Hunt’s (2022, Home Field Advantage: Roots, Reelection, and Representation in the Modern Congress) measure for the US House. We present evidence that state legislators with deep local roots in the districts they represent run unopposed in their general elections nearly twice as often as incumbents with no such roots. Of those who do attract challengers in their reelection efforts, deeply rooted incumbents enjoy an average of three extra percentage points of vote share. Our results have important implications for candidate emergence in state legislative elections during a time when so many are uncontested. They also demonstrate the limits of electoral nationalization for understanding state politics.
Menschenrechte in der schweizerischen Psychiatrie
Authors: Richter Dirk , Rühle Andersson Sabine , Burr Christian , Domonell Kristina , Hasler Melina , Hegedüs Anna , Wolfensberger Peter 
Published: March 2023

Was ist zu diesem Thema bereits bekannt? Menschenrechte sind ein derzeit viel diskutiertes Thema in der psychiatrischen Versorgung. Die Rechte von Menschen mit sogenannten psychosozialen Behinderungen werden in der UN-Behindertenrechtskonvention (UN-BRK) definiert. Wie wird eine neue Perspektive eingebracht? Es werden detaillierte Daten und Analysen für die Umsetzung der Menschenrechte in der psychiatrischen Versorgung der Schweiz präsentiert und die Forderungen der UN-BRK hinsichtlich Rechten, Zwang, Bildung, Gesundheit und Arbeit thematisiert. Was sind die Auswirkungen für die Praxis? In der psychiatrischen Pflege sowie im Gesundheitsund Sozialwesen muss die Menschenrechts-Thematik eine deutlich größere Aufmerksamkeit erfahren.
Computerized Process-Oriented Dynamic Testing of Children’s	Ability to Reason by Analogy Using Log Data
Authors: Veerbeek Jochanan , Vogelaar Bart 
Published: March 2023

Abstract: The study investigated the value of process data obtained from a group-administered computerized dynamic test of analogical reasoning, consisting of a pretest-training-posttest design. We sought to evaluate the effects of training on processes and performance, and the relationships between process measures and performance on the dynamic test. Participants were N = 86 primary school children ( Mage = 8.11 years, SD = 0.63). The test consisted of constructed-response geometrical analogy items, requiring several actions to construct an answer. Process data enabled scoring of the total time, the time taken for initial planning of the task, the time taken for checking the answer that was provided, and variation in solving time. Training led to improved performance compared to repeated practice, but this improvement was not reflected in task-solving processes. Almost all process measures were related to performance, but the effects of training or repeated practice on this relationship differed widely between measures. In conclusion, the findings seemed to indicate that investigating process indicators within computerized dynamic testing of analogical reasoning ability provided information about children’s learning processes, but that not all processes were affected in the same way by training.
On-chip ultrasensitive and rapid hydrogen sensing based on plasmon-induced hot electron–molecule interaction
Authors: Wen Long , Sun Zhiwei , Zheng Qilin , Nan Xianghong , Lou Zaizhu , Liu Zhong , Cumming David R. S. , Li Baojun , Chen Qin 
Published: March 2023

AbstractHydrogen energy is a zero-carbon replacement for fossil fuels. However, hydrogen is highly flammable and explosive hence timely sensitive leak detection is crucial. Existing optical sensing techniques rely on complex instruments, while electrical sensing techniques usually operate at high temperatures and biasing condition. In this paper an on-chip plasmonic–catalytic hydrogen sensing concept with a concentration detection limit down to 1 ppm is presented that is based on a metal–insulator–semiconductor (MIS) nanojunction operating at room temperature and zero bias. The sensing signal of the device was enhanced by three orders of magnitude at a one-order of magnitude higher response speed compared to alternative non-plasmonic devices. The excellent performance is attributed to the hydrogen induced interfacial dipole charge layer and the associated plasmonic hot electron modulated photoelectric response. Excellent agreements were achieved between experiment and theoretical calculations based on a quantum tunneling model. Such an on-chip combination of plasmonic optics, photoelectric detection and photocatalysis offers promising strategies for next-generation optical gas sensors that require high sensitivity, low time delay, low cost, high portability and flexibility.
The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes
Authors: Gosline Sara J. C. , Kim Doo Nam , Pande Paritosh , Thomas Dennis G. , Truong Lisa , Hoffman Peter , Barton Michael , Loftus Joseph , Moran Addy , Hampton Shawn , Dowson Scott , Franklin Lyndsey , Degnan David , Anderson Lindsey , Thessen Anne , Tanguay Robyn L. , Anderson Kim A. , Waters Katrina M. 
Published: March 2023

AbstractThe OSU/PNNL Superfund Research Program (SRP) represents a longstanding collaboration to quantify Polycyclic Aromatic Hydrocarbons (PAHs) at various superfund sites in the Pacific Northwest and assess their potential impact on human health. To link the chemical measurements to biological activity, we describe the use of the zebrafish as a high-throughput developmental toxicity model that provides quantitative measurements of the exposure to chemicals. Toward this end, we have linked over 150 PAHs found at Superfund sites to the effect of these same chemicals in zebrafish, creating a rich dataset that links environmental exposure to biological response. To quantify this response, we have implemented a dose-response modelling pipeline to calculate benchmark dose parameters which enable potency comparison across over 500 chemicals and 12 of the phenotypes measured in zebrafish. We provide a rich dataset for download and analysis as well as a web portal that provides public access to this dataset via an interactive web site designed to support exploration and re-use of these data by the scientific community at http://srp.pnnl.gov.
Chlorin e6-associated photodynamic therapy enhances abscopal antitumor effects via inhibition of PD-1/PD-L1 immune checkpoint
Authors: Gurung Pallavi , Lim Junmo , Shrestha Rajeev , Kim Yong-Wan 
Published: March 2023

AbstractWe hypothesized that photodynamic therapy (PDT) with Chlorin e6 (Ce6) enhances antitumor abscopal effects via inhibition of the programmed cell death-1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint. By using syngeneic melanoma and pancreatic tumor mouse models, we studied the Ce6-PDT-induced immune responses in local and distant tumor microenvironments. In addition, the Ce6-PDT's target in the PD-1/PD-L1 interaction was analyzed in MC38-hPD-L1 colon cancer and PD-1 expressing Jurkat T cell coculture. The tumors in the irradiated and non-irradiated sites in the abscopal effective (Abseff) group of both mouse models were regressed, proving the abscopal effect. The immunogenic effect in the Abseff group was associated with an expansion of T cell and other immune cells infiltration without changes in the CD39+ population in either the right or left tumors compared to control group. Furthermore, the abscopal ineffective (Absineff) group demonstrated lesser increase of T cells, decreased immune cell infiltration, and increased CD39-expressing Treg cells without suppression of tumor growth. In the coculture with PD-1-expressing Jurkat T cell, Ce6-PDT efficiently suppressed the PD-1/PD-L1 interactions by increasing the proliferation and cytotoxic activity of CD8+ T cells while decreasing CD39-expressing Treg cells in a dose-dependent manner. Likewise, the inhibition of PD-1/PD-L1 interactions was also correlated with the increased production of IL-2 and Granzyme B. Our findings imply that Ce6-PDT is a promising immunotherapy with the potential to improve the abscopal effect.
Characterization of serum and tissue oxytocinase and tissue oxytocin in the pregnant and non-pregnant mare
Authors: Diel de Amorim Mariana , Dong Lynn , Byron Michael , Foster Robert A. , Klein Claudia , Saleh Monique , Saleh Tarek , Card Claire 
Published: March 2023

AbstractOxytocin is a hormone with functions in: reproduction, maternal bonding, milk ejection, and feeding/social behavior, and is reported to be present in a variety of tissues. Our goal is to characterize oxytocin and leucyl and cystinyl aminopeptidase (LNPEP/oxytocinase), a key regulator of oxytocin in mares. We measured serum and tissue LNPEP by ELISA from ovulation (D0) until D21–22 in non-pregnant (n = 5) and pregnant mares (n = 6); and in periparturient and postpartum mares (n = 18). Placenta (n = 7) and homogenized tissue of diestrus mares (n = 6) were evaluated using protein determinations and LNPEP ELISAs. Identification of LNPEP and OXT protein in tissues was also performed via western blot, immunohistochemistry and liquid chromatography-mass spectrometry (LC-MS/MS). Furthermore, in situ hybridization was performed for LNPEP and OXT on endometrium, myometrium, pituitary and corpus luteum (CL). Serum LNPEP concentration were similar. Placental LNPEP U/mg protein was highest in the body and pregnant horn. The highest to lowest LNPEP U/mg protein by tissue were: myometrium > follicle wall > endometrium > kidney > CL > liver. Oxytocin was identified in the equine pituitary, CL and placenta and is likely to act in autocrine or paracrine manner, while LNPEP may act systemically and locally to regulate the availability of OXT.
Utilization of optimized microwave sintering to produce safe and sustainable one-part alkali-activated materials
Authors: Refaat Moataz , Mohsen Alaa , Nasr El-Sayed A. R. , Kohail Mohamed 
Published: March 2023

AbstractSodium hydroxide (NaOH) as an alkaline activator presents a vital limitation in the mass production of alkali-activated binders due to its severe effect on users’ safety. In this study, safe and sustainable one-part alkali-activated slag mixes (OP-AAS) were prepared through an efficient microwave sintering for a mixture of active amorphous ground granulated blast furnace slag (GGBFS) and sodium hydroxide powder (NaOH). Different microwave-sintered powders were prepared using microwave energy of power 900 W for the mixture at different treatment periods (10, 20, and 30 min). Fresh and hardened properties of different OP-AAS mixes were studied. Moreover, the phase composition and microstructure were investigated using X-ray diffraction (XRD) analysis and scanning electron microscope (SEM). Cytotoxicity/viability testing was performed to evaluate the cell death induced by the developed materials to measure their safety for the user. According to compressive strength, cytotoxicity/viability analysis, environmental impact and cost calculation of developed OP-AAS, it is concluded that employing microwave sintering for a short duration is sufficient to produce safe binding materials with adequate mechanical properties suitable for commercial applications in the construction sector.
Hypothermia is an independent risk factor for prolonged ICU stay in coronary artery bypass surgery: an observational study
Authors: Wang Yi-Chia , Huang Hsing-Hao , Lin Pei-Ching , Wang Ming-Jiuh , Huang Chi-Hsiang 
Published: March 2023

AbstractMaintenance of normothermia is a critical perioperative issue. The warming process after hypothermia tends to increase oxygen demand, which may lead to myocardial ischemia. This study explored whether hypothermia was an independent risk factor for increased morbidity and mortality in patients receiving CABG. We conducted a retrospective observational study of CABG surgeries performed from January 2018 to June 2019. The outcomes of interest were mortality, surgical site infection rate, ventilator dependent time, intensive care unit (ICU) stay, and hospitalization duration. Data from 206 patients were analysed. Hypothermic patients were taller (p = 0.012), had lower left ventricular ejection fraction (p = 0.016), and had off-pump CABG more frequently (p = 0.04). Our analysis noted no incidence of mortality within 30 days. Hypothermia was not associated with higher surgical site infection rate or longer intubation time. After adjusting for sex, age, cardiopulmonary bypass duration, left ventricular ejection fraction, and EuroSCORE II, higher EuroSCORE II (p < 0.001; odds ratio 1.2) and hypothermia upon ICU admission (p = 0.04; odds ratio 3.8) were independent risk factors for prolonged ICU stay. In addition to EuroSCORE II, hypothermia upon ICU admission was an independent risk factor for prolonged ICU stay in patients receiving elective CABG.
High-force catch bonds between the Staphylococcus aureus surface protein SdrE and complement regulator factor H drive immune evasion
Authors: Paiva Telmo O. , Geoghegan Joan A. , Dufrêne Yves F. 
Published: March 2023

AbstractThe invasive bacterial pathogen Staphylococcus aureus recruits the complement regulatory protein factor H (fH) to its surface to evade the human immune system. Here, we report the identification of an extremely high-force catch bond used by the S. aureus surface protein SdrE to efficiently capture fH under mechanical stress. We find that increasing the external force applied to the SdrE-fH complex prolongs the lifetime of the bond at an extraordinary high force, 1,400 pN, above which the bond lifetime decreases as an ordinary slip bond. This catch-bond behavior originates from a variation of the dock, lock and latch interaction, where the SdrE ligand binding domains undergo conformational changes under stress, enabling the formation of long-lived hydrogen bonds with fH. The binding mechanism dissected here represents a potential target for new therapeutics against multidrug-resistant S. aureus strains.
Gradient to sectioning CUBE workflow for the generation and imaging of organoids with localized differentiation
Authors: Koh Isabel , Hagiwara Masaya 
Published: March 2023

AbstractAdvancements in organoid culture have led to various in vitro mini-organs that mimic native tissues in many ways. Yet, the bottleneck remains to generate complex organoids with body axis patterning, as well as keeping the orientation of organoids during post-experiment analysis processes. Here, we present a workflow for culturing organoids with morphogen gradient using a CUBE culture device, followed by sectioning samples with the CUBE to retain information on gradient direction. We show that hiPSC spheroids cultured with two separated differentiation media on opposing ends of the CUBE resulted in localized expressions of the respective differentiation markers, in contrast to homogeneous distribution of markers in controls. We also describe the processes for cryo and paraffin sectioning of spheroids in CUBE to retain gradient orientation information. This workflow from gradient culture to sectioning with CUBE can provide researchers with a convenient tool to generate increasingly complex organoids and study their developmental processes in vitro.
Why should and how can quantum technologies be leveraged at national levels?
Authors: Baitulmal AbdulMalek , Adem Nadia 
Published: March 2023

AbstractQuantum technologies (QT) promise to change the landscape of technologies disruptively in diverse industries. For this reason, many nations around the globe are investing to emerge within the global quantum ecosystem through initiating national programmes and international partnerships. Nonetheless, some other countries are still running behind and yet their governments need to take series actions to help their private and public sectors adapt to the looming changes, considering the new regulations required and the huge influence that QT will present in the near future. In this opinion piece, the authors provide, to the best of their knowledge, the first generally applicable, yet comprehensive and brief, framework for leveraging the emerging QT to facilitate the establishment of national initiatives properly. The insights presented in this article were driven based on investigating various approaches, initiatives, and roadmaps adopted globally and meeting with local and regional leaders, professionals, and governmental officials. Furthermore, taken into account socioeconomic and institutional dimensions of the Libyan society, the framework for the Libyan nation is projected. This opinion piece is intended to inspire researchers, technical industrial experts, stakeholders, and governmental bodies to find roles they need to play to bring QT forward.
Exploring the environment, magnetic fields, and feedback effects of massive high-redshift galaxies with [C II]
Authors: Kade K. , Knudsen K. K. , Vlemmings W. , Stanley F. , Gullberg B. , König S. 
Published: March 2023

Context. Massive galaxies are expected to grow through different transformative evolutionary phases. High-redshift starburst galaxies and quasars are thought to be such phases and thus provide insight into galaxy evolution. Several physical mechanisms are predicted to play an important role in driving these phases; for example, interaction with companion galaxies, active galactic nuclei feedback, and possibly magnetic fields.
Aims. Our aim is to characterize the physical properties and the environment of the submillimeter galaxy AzTEC-3 at z = 5.3 and the lensed quasar BRI 0952−0115 at z = 4.4, and to set a limit on the polarization properties of the two sources. We intend to place these two sources in the broader context of galaxy evolution, specifically star formation and mass growth through cosmic time.
Methods. We used full polarization, sub-arcsecond-resolution, ALMA band-7 observations of both BRI 0952−0115 and AzTEC-3. We detect [C II] (2P3/2−2P1/2) line emission towards both BRI 0952−0115 and AzTEC-3, along with companions in each field. We present an updated gravitational lensing model for BRI 0952−0115 for correction of gravitational magnification.
Results. We present infrared luminosities, star-formation rates, and [C II] line to infrared luminosity ratios for each source. The [C II] emission line profile for both BRI 0952−0115 and AzTEC-3 exhibit a broad, complex morphology, indicating the possible presence of outflows. We present evidence of a “gas bridge” between AzTEC-3 and a companion source. Modified blackbody spectral energy distribution fitting is used to analyze the properties of [C II] detected companion sources in the field of both the submillimeter galaxy and the quasar. We investigated the possible role of the detected companions in outflow signatures. Using a simple dynamical mass estimate for the sources, we suggest that both systems are undergoing minor or major mergers. No polarization is detected for the [C II], placing an upper limit below that of theoretical predictions.
Conclusions. Our results show that high-velocity wings are detected, indicating possible signs of massive outflows; however, the presence of companion galaxies can affect the final interpretation. Furthermore, the results provide additional evidence in support of the hypothesis that massive galaxies form in overdense regions, growing through minor or major mergers with companion sources. Finally, strong, ordered magnetic fields are unlikely to exist at the kiloparsec scale in the two studied sources.