bluuebunny/crossref_metadata_2025_split huggingface dataset:
PLAY THERAPY COLORING UNTUK MENURUNKAN KECEMASAN ANAK PRASEKOLAH YANG MENGALAMI HOSPITALISASI DI RSUD JOMBANG JAWA TIMUR
Authors: Nurjanah Suci , Santoso Shelfi , Prasetyo Joko , Wijaya Arif , Kusyani Asri 
Published: April 2023

Hospitalisasi pada anak memiliki dampak jangka panjang dan dampak jangka pendek. dampak jangka pendek berupa ketakutan dan kecemasan sehingga bila tidak ditangani segera anak akan melakukan penolakan terhadap perawatan dan pengoobatan yang akan diberikan, selain itu dampak jangka pendek yang mungkin muncul adalah susah tidur, menangis dan takut dengan tim kesehatan sehingga anak menolak tindakan perawatan yang diberikan kepada anak, hal ini akan berpengaruh terhadap lamanya hari rawat, memberat kondisi anak dan menyebabkan kematian. kecemasan akan menimbulkan respon fisiologis yakni perubahan sistim kardiovaskuler dan perubahan pola nafas yang terengah-engah. Ketakutan dan kecemasan merupakan gangguan terhadap terpenuhinya kebutuhan emosional anak, yang diperlukan penanganan sesegera mungkin karena berdampak pada pertumbuhan den perkembangan . Terapi bermain (Play Therapy) merupakan salah satu metode non-farmakologis yang dapat menurunkan tingat kecemasan anak. Kegiatan pengabdian masyarakat ini bertujuan untuk mengimplementasikan Play Therapy sebagai intervensi untuk menurunkan tingkat kecemasan anak yang mengalami hospitalisasi. Kegiatan ini diikuti oleh 20 anak yang dirawat inap di ruang srikandi RSUD Jombang pada bulan Juni-Juli 2021. Kegiatan Play Therapy dengan memberikan gambar dan anak dibebaskan mememilih gambar yang disukai untuk diwarnai. Sebelum dan setelah pemberian intervensi dilakukan pengukuran tingkat kecemasan anak dengan menggunakan Face Anxiety scale (FAS) dan data dianalisis dengan dengan uji statistik paired t-test dengan bantuan spss 16 dengan tingkat kemaknaan α< 0,05. Hasil kegiatan menunjukkan perbedaan signifikan tingkat kecemasan anak sebelum dan sesudah dilakukan Play therapy Coloring dimana setelah terapi bermain terjadi penurunan tingkat kecemasan anak. Kegiatan terapi bermain efektif untuk diterapkan sebagai salah satu metode intervensi dalam penurunkan tingkat kecemasan anak yang mengalami hospitalisasi.
ПОПЕРЕДЖЕННЯ ПСИХОТРАВМ ПРИ РІЗНИХ РЕАКЦІЯХ НА ВПЛИВ ПСИХОГЕННИХ ЧИННИКІВ
Authors: ГІРЧЕНКО Олена 
Published: April 2023

У статті розглянуто поняття психотравми, наведено теоретичний аналіз проблеми дослідження психотравм при різних реакціях на вплив психогенних факторів (чинників),досліджено психогенні фактори та їх вплив на психіку військовослужбовців.
Мета статті полягає у дослідженні закономірностей впливу психотравм при різних реакціях на психогенні фактори.
Важливість психологічного вивчення феномену «психотравма», її психологічний зміст та структура, значення у змінах стану психічного та фізичного здоров'я людини, постійно відзначається вченими з різних галузей психологічної науки (загальна психологія, медична психологія, психофізіологія, інженерна психологія, практична психологія, спортивна психологія та ін.), вченими граничних та дружніх галузей знань (медицина, валеологія, педагогіка, фізкультура та диспут та ін.). У вітчизняній психології вивчення проблеми «психотравми» досить рідкісні та мають розсіяний та фрагментарний характер. Здебільшого, це пов'язано з відомими соціальними причинами – умовами, які відображають сприйняття людиною навколишньої реальності як загрозливої та нестійкої.
Детально розглянувши сучасний стан вивчення феномену «психотравма», його психологічний зміст, можна дійти висновку, що сьогоднішній стан суспільства характеризується посиленням дії факторів, які сприяють психічній травматизації особистості. і зниження якості життя людини. До таких чинників належать: відносно нестабільна політична ситуація в країні та світі, соціально-економічна невизначеність і тривога, екстремальні життєві події (пандемія, війна, міграція).
На нашу думку, психологічна травма або психотравма – це пошкодження від впливу на психіку людини негативних факторів, які можуть сприяти розвитку психічних захворювань. Часто наявність психологічної травми може призвести до того, що людині знадобиться лікування посттравматичного стресового розладу. Психотравма може бути пов'язана з фізичною травмою, що загрожує життю людини або порушує почуття безпеки, що супроводжується сильним емоційним потрясінням.
Association of use of different type of manual therapy approach with upper extremity pain in manual therapists of Lahore”
Authors: Hafiz Muneeb ur Rehman  , Zulfiqar Hunza , Anwer Hajira , Naina Nayab 
Published: April 2023

This study was conducted to assess the upper limb pain in manual physiotherapists by using different manual therapy techniques.There was no such type of study in Pakistan and also there was less literature found on this study internationally.It was a cross sectional study . Data was collected from the manual physiotherapists of Lahore from different clinical settings. The data collection was done by using Non probability convenient sampling technique. The Sample size was 126, calculated from (“Raosoft” software). The questionnaire used to assess pain was the Standard Nordic musculoskeletal questionnaire. For the statistical analysis, SPSS 20 software was used to find the association of use of a different type of manual therapy approach with upper extremity pain in the manual therapist. The mean age of physiotherapists was 34.6 (SD = 5.996). Out of 126, male physiotherapist 66 and 60 were female. Mostly Physiotherapists who were included in this study had working experience of more than 5 years and practicing more than 3 hours a day had upper limb pain. Physiotherapists using manual therapy techniques Kalterborn technique had more pain in the neck, shoulder, elbow,wrist and hand than physiotherapists using Mulligan and Maitland. There was no association of any technique used by physiotherapists with shoulder, elbow, wrist/hand and neck pain (p>0.05). This study concluded that physiotherapists using Kalternborn technique reported more upper limb pain than therapists using the maitland and mulligan techniques. There was no association of any technique used by hysiotherapists with shoulder, elbow, wrist/hand and neck pain.
Investigating lactation curve characteristics of dairy cows
Authors: Kramarenko O. S. 
Published: April 2023

The main goal of this study was to analysis of the main characteristics (latent variables) of lactation curve in dairy cows using multivariate Principal Component Analysis. This work used primary database from the milk production of Holstein cows (n = 238 heads) in the PJSC “Pedigree farm ‘Stepnoy’ Kamianka-Dniprovska Raion of Zaporizhzhia Oblast over a 4-yr period (2014-2017). Recording is done with an interval of 30 days for 10 test-days (TD1-TD10), i.e., TD1 is milk production recorded on milking day 30th, TD2 is day 60th, TD3 is day 90th, etc., and 305-day milk yield records (Y305) were used also. High significant correlations were found between daily milk yields for certain test-days. The Principal Component Analysis performed on the variance-correlation matrix of TD1-TD10 records are able to explain about 90.33 % of the total variance. The first principal component (PC1) explained 66.32 % of the total variance and was highly-positively correlated with TD2-TD10 records. Thus, PC1 were defined as “total milk production”. The second principal component (PC2) explained 19.06 % of the total variance and was highly-positively correlated with TD1-TD2 records and highly-negatively correlated with TD9-TD10 records. Thus, PC2 were defined as “lactation curve persistency”. Finally, the third principal component (PC3) explained 4.95 % of the total variance and was highly-positively correlated with TD1 and TD10 records and highly-negatively correlated with TD4-TD5 records. Thus, PC3 were defined as “lactation curve type”. The use of a multivariate method (namely, the PCA) for the analysis of lactation curve characteristics based on monthly test-day records gave very close results of the analysis of milk productivity in different groups of domestic animals (cattle, goats and sheep). In all cases, the first principal component (PC1) described the absolute level of milk productivity during lactation, and the second principal component (PC2) described the persistency of the lactation curve. Significant influence on the PC1-PC3 factor scores was revealed to the greatest extent for such non-genetic factors as age of cow (in lactations), year and month of calving. Of the genetic factors, the greatest influence on the shape of the lactation curve was not so much the differences between the bull lines (Bell, Valiant, Elevation, Starbuck and Chief), but differences between individual bulls within some lines.
Modificación del maxilar de niños de 8 a 12 años posterior al uso de MARPE. Revisión de literatura
Authors: Kagawa Tenesaca Kiyoko Samantha , Palmas Oscar Sergio 
Published: April 2023

Fundamentos: La deficiencia maxilar transversal, se caracteriza por un deficiente crecimiento del maxilar, se encuentra estrechamente asociado con apiñamiento dental, mordida cruzada, maloclusión clase II y clase III y disfunción de la articulación temporomandibular, es así que, la expansión palatina rápida asistida por microtornillos (MARPE) se desarrolló con el propósito de lograr la expansión maxilar sin intervención quirúrgica. Objetivo: Analizar las modificaciones en el maxilar posterior al uso de MARPE en niños de 8 a 12 años. Métodos: La literatura se seleccionó mediante una búsqueda en las bases de datos electrónicas: Pubmed, Springer, Cochrane Library, Google Academic, Proquest, Web of science, Taylor & Francis. La búsqueda de la información se realizó con temporalidad desde enero del año 2012 a enero del año 2023, con la inclusión de todos los idiomas. Resultados: Después de aplicar los criterios de inclusión en total se obtuvieron y revisaron 16 artículos. Conclusiones: La literatura disponible demostró que MARPE podría reducir la pérdida del espesor óseo alveolar bucal y del nivel óseo marginal en el área de los primeros premolares que la expansión rápida palatal convencional. Sin embargo, la baja calidad de la evidencia, hacen que estas afirmaciones no sean concluyentes. Por lo que, se alienta a los investigadores a realizar nuevos estudios, de preferencia estudios que utilicen muestras significativas y con una duración de seguimiento más prolongado para identificar cuáles son los efectos a largo plazo y su recidiva.
RESPON PENGGUNA JALAN TERHADAP KEBERADAAN PASAR KAGET DI JALAN AKSES CIKEAS-CIMANGGIS
Authors: Mulyana Dede , Widodo Pamuji , Cecep Cecep 
Published: April 2023

Pasar merupakan salah satu tempat terlaksananya transaski antara penjual dan pembeli, baik dengan pedagang atau petani atau dengan para penjual yang berada di pasar. Di Cikeas-Cimanggis setiap hari minggu terdapat sebuah kegiatan yang rutin dilaksanakan yaitu adanya pasar kaget. Pasar kaget yaitu pasar yang ketersediaannya hanya dalam waktu-waktu tertentu saja dan lokasi keberadaannya tertentu juga yang ramai dengan para pengguna jalan. Ketersediaan pasar kaget yang terletak di akses Cikeas-Cimanggis dimana memiliki dampak langsung terhadap masyarakat sekitar dan juga bagi para pengguna jalan. Tujuan daripada penelitian ini yaitu untuk mengetahui tentang respon masyarakat akan keberadaan pasar kaget di sekitar para pengguna jalan. Penelitian ini menggunakan sebuah metode kualitatif yaitu dengan melakukan survei primer berupa kuisioner, observasi, wawancara, dokumentasi, dan study pustaka. Kesimpulan dalam penelitian ini adalah dimana terdapat respon yang positif dan respon negatif terhadap adanya dan keberadaannya pasar kaget yang berupa antusias dari masyarakat yang membeli kebutuhan dilokasi tersebut. Kata kunci: pasar, pasar kaget, pengguna jalan, respon ABSTRACT The market is one of the places where transactions are carried out between sellers and vendees, either with traders or farmers or with sellers in the market. In Cikeas-Cimanggis every Sunday there is a fray that is routinely carried out, namely the shaped market. So the shaped market is a market where its availability is only at that time and a certain place of existence is also where it is teeming with road users. The availability of the shaped market which is located in the Cikeas-Cimanggis access which has a direct leverage on the peripheral community and also for road users. The expect or purpose of this research is to find out about the response of the surrounding environment to the existence of a shaped market around road users. In this study, a qualitative method was used, define by conducting a primary survey in the form of questionnaires, observations, interviews, documentation and literature study. And the conclusion in this study is where there is a positive response and a negative response to the existence and existence of a shaped market in the form of enthusiasm from the people who buy necessities at that location. Keywords: market, shaped market, response, road users
EXPERIENCE TOUR PADA ERA NEW NORMAL BERBASIS NEOPHILIAN PERSONALITY: PERAN TRAVEL MOTIVES
Authors: Riptiono Sulis , Wibawanto Sigit 
Published: April 2023

Penelitian ini bertujuan untuk menguji peran motif perjalanan sebagai mediasi antara kepribadian neophilia dan pengalaman. Penelitian ini melibatkan 182 wisatawan di Kebumen sebagai sampel yang diambil dengan menggunakan tehnik purposive sampling. Data yang terkumpul diolah dengan menggunakan bantuan slat statistic SPSS dan dianalisis dengan menggunakan analisis jalur dan uji sobel. Hasil penelitian menunjukkan bahwa kepribadian neophilia konsumen terbukti berpengaruh positif terhadap motif perjalanan wisatawan dan pengalaman. Hal ini menunjukkan bahwa semua hipotesis yang diuji dalam penelitian ini dinyatakan diterima. Temuan lain juga menunjukkan bahwa motif perjalanan terbukti sebagai pemediasi antara kepribadian neophilian dan pengalaman. Kata kunci: Kebumen, pandemic covid-19, tourism marketing, wisata travel ABSTRACT This study aims to examine the role of travel motives as a mediator between neophilic personality and experience. This study involved 182 tourists in Kebumen as samples taken using purposive sampling technique. The collected data was processed using SPSS statistical slats and analyzed using path analysis and Sobel test. The results showed that the consumer's neophilic personality proved to have a positive effect on tourists' travel motives and experiences. This shows that all the hypotheses tested in this study are accepted. Other findings also suggest that travel motives are shown to mediate between neophilian personality and experience. Keywords: Kebumen, pandemic covid-19, tourism marketing, travelling
ANALISIS BUDAYA KERJA DAN LINGKUNGAN KERJA TERHADAP PRESTASI KERJA PEGAWAI
Authors: Handayani Ris , Laela Siti , Meryati Meryati 
Published: April 2023

Penelitian ini dilakukan karena adanya dugaan permasalahan yang ada di Dinas Penanaman Modal dan Pelayanan Terpadu di Depok, Jawa Barat. Penelitian dilakukan menganalisis apakah ada pengaruh budaya kerja dan lingkungan kerja terhadap prestasi kerja pegawai Dinas Penanaman Modal serta Pelayanan Terpadu Kota Depok. Metode penelitian yang digunakan dengan pendekatan kuantitatif, menggunakan analisis regresi berganda dengan populasi adalah keseluruhan karyawan Dinas Penanaman Modal dan Pelayayan Terpadu yang berjumlah 60 pegawai. Penelitian ini menggunakan teknik total sampling dengan sensus. Populasi diambil secara keseluruhan dijadikan sebagai responden. Hasil penelitian ini menunjukkan hasil bahwa budaya kerja berpengaruh positif dan signifikan terhadap prestasi kerja pegawai demikian juga dengan hasil lingkungan kerja berpengaruh positif dan signifikan terhadap prestasi kerja. Dapat disimpulkan secara simultan mempunyai pengaruh yang positif di antara variabel independen terhadap variabel dependen. Kata kunci: budaya kerja, lingkungan kerja, prestasi kerja ABSTRACT This research was conducted because of the alleged problems that exist in The Investment and Integrated Service Department in Depok, West Java. The study was conducted to analyze whether there is an influence of work culture and work environment on the work performance of the employees of The Investment Office and Integrated Services in Depok. The research method used is a quantitative approach, using multiple regression analysis, with the population consisting of 60 employees of the integrated investment and service department. This study uses a total sampling technique, with a census. The population is taken as a whole as respondents. The results of this study indicate that work culture has a positive and significant effect on employee performance as well as the results of the work environment having a positive and significant effect on work performance. It can be concluded that simultaneously has a positive influence between the independent variables on the dependent variable. Keywords: work culture, work environment, work performance.
Klasifikasi Penyakit Tuberculosis (TB) Organ Paru Manusia Berdasarkan Citra Rontgen Thorax Menggunakan Metode Convolutional Neural Network (CNN)
Authors: Rasyid Aulia , Heryawan Lukman 
Published: April 2023

Tuberculosis (TB) adalah suatu penyakit infeksi menular yang disebabkan oleh Mycobacterium Tuberculosis dan dapat menyerang berbagai organ dalam tubuh manusia terutama paru-paru. Pemeriksaan diagnosis pada penyakit TB-paru dapat dilakukan dengan melihat keluhan atau gejala klinis pasien, pemeriksaan biakan, pemeriksaan mikroskopis, radiologi ataupun tuberculin test. Selama ini, paramedis mendiagnosis penderita TB tersebut hanya berdasarkan citra rontgen secara manual. Oleh karena itu, diperlukan adanya Artificial Intelligence (AI) untuk membantu dan mempermudah dokter dalam mengklasifikasi penyakit TB paru berdasarkan citra rontgen thorax.Penelitian ini merancang klasifikasi citra x ray penyakit tuberculosis berbasis Convolutional Neural Network (CNN) menggunakan arsitektur MobileNet. Dataset berupa citra X-ray paru yang akan digunakan sebagai masukan untuk proses pengolahan citra atau image processing. Tahapan pertama yaitu input berupa citra X-ray, selanjutnya dilakukan proses preprocessing citra (resizing, grayscale, contrast), dilanjutkan dengan proses segmentation (thresholding), dilanjutkan dengan proses augmentasi data, terakhir citra akan diklasifikasikan menjadi tiga kelas yaitu normal, TBR(tuberculosis bagian kanan), TBRL (tuberculosis bagian kanan dan kiri). Tuberculosis bagian kiri tidak masuk kedalam klasifikasi dikarenakan tuberculosis lebih cenderung terkena pada bagian kanan atau di kedua bagian.Dalam penelitian ini dilakukan pengujian terhadap pengaruh citra ( tanpa image processing , preprocessing dan segmentation) , pengaruh batch size ,pengaruh variasi epoch, pengaruh augmentasi dan perbandingan terhadap performa klasifikasi. Hasil akhir dari penelitian ini menunjukan optimizer terbaik yaitu Adam menggunakan preprocessing CLAHE pada epoch 50 batch size 32 dan menghasilkan nilai akurasi validasi sebesar accuracy sebesar 96.837%, precision 95%, recall 93%, F-1 score sebesar 93%,Â dan loss sebesar 0.210.
Single-cell RNA sequencing analysis of human chondrocytes reveals cell–cell communication alterations mediated by interactive signaling pathways in osteoarthritis
Authors: Kang Xin , Zhang Kailiang , Wang Yakang , Zhao Yang , Lu Yao 
Published: April 2023

Objective: Osteoarthritis (OA) is a common joint disorder characterized by degenerative articular cartilage, subchondral bone remodeling, and inflammation. Increasing evidence suggests that the substantial crosstalk between cartilage and synovium is closely related to Osteoarthritis development, but the events that cause this degeneration remain unknown. This study aimed to explore the alterations in intercellular communication involved in the pathogenesis of Osteoarthritis using bioinformatics analysis.Methods: Single-cell transcriptome sequencing (scRNA-seq) profiles derived from articular cartilage tissue of patients with Osteoarthritis were downloaded from a public database. Chondrocyte heterogeneity was assessed using computational analysis, and cell type identification and clustering analysis were performed using the “FindClusters” function in the Seurat package. Intercellular communication networks, including major signaling inputs and outputs for cells, were predicted, and analyzed using CellChat.Results: Seven molecularly defined chondrocytes clusters (homeostatic chondrocytes, hypertrophic chondrocyte (HTC), pre-HTC, regulatory chondrocytes, fibro-chondrocytes (FC), pre-FC, and reparative chondrocyte) with different compositions were identified in the damaged cartilage. Compared to those in the intact cartilage, the overall cell–cell communication frequency and communication strength were remarkably increased in the damaged cartilage. The cellular communication among chondrocyte subtypes mediated by signaling pathways, such as PTN, VISFATIN, SPP1, and TGF-β, was selectively altered in Osteoarthritis. Moreover, we verified that SPP1 pathway enrichment scores increased, but VISFATIN pathway enrichment scores decreased based on the bulk rna-seq datasets in Osteoarthritis.Conclusion: Our results revealed alterations in cell–cell communication among OA-related chondrocyte subtypes that were mediated by specific signaling pathways, which might be a crucial underlying mechanism associated with Osteoarthritis progression.
LZM008, a proposed tocilizumab biosimilar: Pharmacokinetics, safety, and immunogenicity profiles compared with ACTEMRA® in Chinese healthy male subjects
Authors: Cao Guoying , Wang Jingjing , He Jinjie , Hu Yingying , Yang Haijing , Que Linling , Gu Xianghong , Yu Jicheng , Wu Xiaojie , Wu Jufang , Fang Wei , He Qing , Zhang Jing 
Published: April 2023

Background: This study aimed to investigate the pharmacokinetics, safety, and immunogenicity of recombinant humanized anti-human IL-6R monoclonal antibody injection, LZM008, and evaluate the pharmacokinetic similarity between LZM008 and tocilizumab (ACTEMRA®) in Chinese healthy male subjects.Research design and methods: In this randomized, double-blinded, paralleled, two-center Phase I clinical trial, 96 subjects were randomized with a 1:1 ratio to receive 4 mg/kg intravenous dose of LZM008 or ACTEMRA® and evaluated for 28 days. The pharmacokinetic bioequivalence was assessed by the maximum serum concentration (Cmax), the area under the serum concentration–time curve (AUC) from time 0 to the last detectable drug concentration (AUC0-t), and AUC0-∞. The statistical analysis was conducted using SAS Enterprise Guide statistical software. Safety was assessed by physical examinations, vital signs, laboratory tests, and electrocardiograms. Anti-drug antibodies (ADAs) were measured by a bridged electrochemiluminescence immunoassay.Results: LZM008 (N = 49) and ACTEMRA® (N = 47) groups showed similar pharmacokinetic properties. After a single intravenous infusion of 4 mg/kg LZM008, the Cmax and AUC0-∞ values of LZM008 reached 87.99 μg/mL and 11,526.70 h*μg/mL, respectively, with Tmax 1.98 h, and the half-life (t1/2) was 83.45 h. The 90% confidence intervals of ratios for Cmax, AUC0-t, and AUC0-∞ were within the range of 80.00%–125.00%. After infusion, one (2.0%) subject in the LZM008 group and three (6.4%) subjects in the ACTEMRA® group showed positive ADA test results. The incidence of treatment emergent adverse events (TEAEs) was comparable in LZM008 and ACTEMRA® groups (98.0% versus 100%), with the decrease in blood fibrinogen and neutrophil counts being the most common TEAEs.Conclusion: The pharmacokinetic characteristics and immunogenicity exhibited by LZM008 were similar to those of the reference product, ACTEMRA®. The safety profiles of LZM008 were similar in the two groups with mild–moderate adverse effects.Trial Registration: The trial is registered at www.chinadrugtrials.org.cn (CTR20190889).