bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Primary hepatic neuroendocrine tumor: two cases report with literature review
Authors: Tang Yongsheng , Chen Xianyu , Lu Xu , Yuan Zenan , Yang Yang , Qiu Chunhui , Li Hua 
Published: August 2023

Background &amp; AimsPrimary hepatic neuroendocrine tumors (PHNETs) are rare malignant liver tumors that present diagnostic challenges owing to their rarity and absence of specific clinical features. This study aimed to investigate the characteristics of this rare liver tumor to enhance our understanding of the disease, improve diagnostic accuracy, and explore standardized diagnostic and treatment approaches.Case descriptionDuring physical examination, two elderly women, aged 64 and 74 years, were found to have liver masses. 18F-FDG Positron Emission Tomography-Computed Tomography (18F-FDG PET-CT) and Ga68-DOTATATE PET-CT scans of both individuals revealed multiple liver masses that were initially suspected to be hepatic neuroendocrine tumors. Subsequent puncture pathology confirmed the diagnosis of neuroendocrine tumors. Furthermore, in Case 1, the tumor was also detected by 18F-FDG PET-CT in the lung, suggesting a metastatic tumor, in conjunction with liver immunohistochemistry and imaging findings. Laboratory tests revealed no significant abnormalities in liver function or autoimmune liver disease indicators, and there was no evidence of viral hepatitis infection. However, partial hepatectomy was not indicated for cases with distant metastasis or multiple space-occupying lesions. Individualized treatment approaches have been developed for such situations. A large portion of the tumor underwent Transarterial Embolization (TAE), and targeted combination chemotherapy or endocrine therapy was administered based on the pathological results. During regular follow-ups a 13 and 12 months, the tumor remained stable. The patients’ quality of life was good, and their psychological well-being was healthy. They led active lifestyles, demonstrated a thorough understanding of their disease and its progression, and actively cooperated during the follow-up process.ConclusionOur findings suggest that a combination of serological, radiological, and immunohistochemical examinations can aid in the diagnosis of PHNET. In addition, we determined that TAE combined with drug therapy could be an effective method for controlling PHNET progression. Regular postoperative follow-ups are important for monitoring the prognosis and tumor progression status of patients with PHNET.
Marine heatwave temperatures enhance larval performance but are meditated by paternal thermal history and inter-individual differences in the purple sea urchin, Strongylocentrotus purpuratus
Authors: Leach Terence S. , Hofmann Gretchen E. 
Published: August 2023

Marine heatwave (MHW) events, characterized by periods of anomalous temperatures, are an increasingly prevalent threat to coastal marine ecosystems. Given the seasonal phenology of MHWs, the full extent of their biological consequences may depend on how these thermal stress events align with an organism’s reproductive cycle. In organisms with more complex life cycles (e.g., many marine invertebrate species) the alignment of adult and larval environments may be an important factor determining offspring success, setting the stage for MHW events to influence reproduction and development in situ. Here, the influence of MHW-like temperatures on the early development of the California purple sea urchin, Strongylocentrotus purpuratus, were explored within the context of paternal thermal history. Based on temperature data collected during MHW events seen in Southern California from 2014–2020, adult urchins were acclimated to either MHW or non-MHW temperatures for 28 days before their sperm was used to produce embryos that were subsequently raised under varying thermal conditions. Once offspring reached an early larval stage, the impact of paternal and offspring environments were assessed on two aspects of offspring performance: larval size and thermal tolerance. Exposure to elevated temperatures during early development resulted in larger, more thermally tolerant larvae, with further influences of paternal identity and thermal history, respectively. The alignment of paternal and offspring exposure to MHW temperatures had additional positive benefits on larval thermal tolerance, but this tolerance significantly decreased when their thermal experience mismatched. As the highest recorded temperatures within past MHW events have occurred during the gametogenesis of many kelp forest benthic marine invertebrate species, such as the purple sea urchin, such parental mediated impacts may represent important drivers of future recruitment and population composition for these species.
Predicting corn tiller development in restrictive environments can be achieved to enhance defensive management decision tools for producers
Authors: Veenstra Rachel L. , Hefley Trevor J. , Berning Dan , Messina Carlos D. , Haag Lucas A. , Prasad P.V. Vara , Ciampitti Ignacio A. 
Published: August 2023

IntroductionWhile globally appreciated for reliable, intensification-friendly phenotypes, modern corn (Zea mays L.) genotypes retain crop plasticity potential. For example, weather and heterogeneous field conditions can overcome phenotype uniformity and facilitate tiller expression. Such plasticity may be of interest in restrictive or otherwise variable environments around the world, where corn production is steadily expanding. No substantial effort has been made in available literature to predict tiller development in field scenarios, which could provide insight on corn plasticity capabilities and drivers. Therefore, the objectives of this investigation are as follows: 1) identify environment, management, or combinations of these factors key to accurately predict tiller density dynamics in corn; and 2) test outof-season prediction accuracy for identified factors.MethodsReplicated field trials were conducted in 17 diverse site-years in Kansas (United States) during the 2019, 2020, and 2021 seasons. Two modern corn genotypes were evaluated with target plant densities of 25000, 42000, and 60000 plants ha -1. Environmental, phenological, and morphological data were recorded and evaluated with generalized additive models.ResultsPlant density interactions with cumulative growing degree days, photothermal quotient, mean minimum and maximum daily temperatures, cumulative vapor pressure deficit, soil nitrate, and soil phosphorus were identified as important predictive factors of tiller density. Many of these factors had stark non-limiting thresholds. Factors impacting growth rates and photosynthesis (specifically vapor pressure deficit and maximum temperatures) were most sensitive to changes in plant density. Out-of-season prediction errors were seasonally variable, highlighting model limitations due to training datasets.DiscussionThis study demonstrates that tillering is a predictable plasticity mechanism in corn, and therefore could be incorporated into decision tools for restrictive growing regions. While useful for diagnostics, these models are limited in forecast utility and should be coupled with appropriate decision theory and risk assessments for producers in climatically and socioeconomically vulnerable environments.
Why should I switch on my camera? Developing the cognitive skills of compassionate communications for online group/teamwork management
Authors: Jayasundara J. M. P. V. K. , Gilbert Theo , Kersten Saskia , Meng Li 
Published: August 2023

IntroductionAssociated with learning and social isolation from each other during the pandemic-driven transition to online platforms in Higher Education (HE), many students were, and remain, reluctant to turn on their video cameras to be present with each other during their online meetings.Using the Compassionate Mind Foundation's definition of compassion, not as an emotion, but as a psychobiological motivation to take wise action to help when self or others struggle, this comparative study examined (a) the deployment by students during online, task-focused group/team meetings, of taught verbal and non-verbal communication strategies that were explicitly compassionate and (b) the effects of these strategies on each other's social and learning experiences in these meetings, compared to when they did not use them.MethodsTwenty-four STEM students from a sample of five Sri Lankan universities, were mixed, then divided into six groups of four students per group. This mixed-methods study, video-recorded and analyzed each group's task-focused group meetings before, then after, an online interactive 90-min training session (the intervention) in the Cognitive Skills of Compassionate Communications (CSCC) for groups/teams.ResultsUsing R, SPSS and Microsoft Excel to analyse the quantitative data, a statistically significant improvement in students' screen-gaze attentiveness was identified after the CSCC intervention. The qualitative data analysis explained this and other behavioral changes that were shown to enhance students' social and learning experiences in their online meetings.Given the strong historical and political drivers of current divisions across Sri Lankan student communities, these findings call for more urgent research on compassion as a cognitive competence for accelerating group/team cohesion and criticality across HE, and beyond.
Daily survey participation and positive changes in mental health symptom scores among Royal Canadian Mounted Police Cadets
Authors: Shields Robyn E. , Teckchandani Taylor A. , Asmundson Gordon J. G. , Nisbet Jolan , Krakauer Rachel L. , Andrews Katie L. , Maguire Kirby Q. , Jamshidi Laleh , Afifi Tracie O. , Lix Lisa M. , Brunet Alain , Sauer-Zavala Shannon , Krätzig Gregory P. , Neary J. Patrick , Sareen Jitender , Carleton R. Nicholas 
Published: August 2023

IntroductionRoyal Canadian Mounted Police (RCMP) officers self-report high levels of mental health disorder symptoms, such as alcohol use disorder, generalized anxiety disorder, major depressive disorder, panic disorder, and posttraumatic stress disorder. Participation in regular mental health monitoring has been associated with improved mental health disorder symptom reporting and may provide an accessible tool to support RCMP mental health. The current study assessed relationships between self-reported mental health disorder symptoms and the completion of daily surveys (i.e., daily mental health disorder symptom monitoring) by RCMP cadets during the Cadet Training Program (CTP).MethodsParticipants were RCMP cadets (n = 394; 76.1% men) in the Standard Training Program who completed the 26-week CTP and daily self-monitoring surveys, as well as full mental health assessments at pre-training (i.e., starting the CTP) and pre-deployment (i.e., ~2 weeks prior to deployment to the field). Symptoms of alcohol use disorder, generalized anxiety disorder, major depressive disorder, panic disorder, and posttraumatic stress disorder were assessed. Changes in mental health disorder symptom reporting from pre-training to pre-deployment were calculated. Spearman’s rank correlations were estimated for number of daily surveys completed and change in mental health disorder symptom scores between pre-training and pre-deployment.ResultsThere were statistically significant inverse relationships between number of daily surveys completed and number of mental health disorder symptoms reported; specifically, cadets who completed more daily surveys during CTP reported fewer symptoms of alcohol use disorder, generalized anxiety disorder, major depressive disorder, panic disorder, and posttraumatic stress disorder.ConclusionAn inverse correlation between number of daily surveys completed and mental health disorder symptom scores indicated that participation in daily mental health monitoring was associated with improvements in self-reported mental health disorder symptoms between pre-training and pre-deployment. Regular self-monitoring of mental health disorder symptoms may help to mitigate mental health challenges among RCMP cadets and officers.
Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study
Authors: Clavo Bernardino , Cánovas-Molina Angeles , Díaz-Garrido Juan A. , Cañas Silvia , Ramallo-Fariña Yolanda , Laffite Horus , Federico Mario , Rodríguez-Abreu Delvys , Galván Saray , García-Lourve Carla , González-Beltrán Damián , Caramés Miguel A. , Hernández-Fleta Jose L. , Serrano-Aguilar Pedro , Rodríguez-Esparragón Francisco 
Published: August 2023

BackgroundPatients with refractory symptoms of severe diseases frequently experience anxiety, depression, and an altered health-related quality of life (HRQOL). Some publications have described the beneficial effect of ozone therapy on several symptoms of this kind of patient. The aim of this study was to preliminarily evaluate, in patients treated because of refractory symptoms of cancer treatment and advanced nononcologic diseases, if ozone therapy has an additional impact on self-reported anxiety and depression.MethodsBefore and after ozone treatment, we assessed (i) anxiety and depression according to the Hospital Anxiety and Depression Scale (HADS); (ii) the HRQOL (according to the EQ-5D-5L questionnaire), which includes a dimension on anxiety and depression and a visual analog scale (VAS) measuring self-perceived general health.ResultsBefore ozone therapy, 56% of patients were on anxiolytic and/or antidepressant treatment. Before and after ozone therapy, the anxiety and depression HADS subscales (i) significantly correlated with the anxiety/depression dimension of the EQ-5D-5L questionnaire and (ii) inversely correlated with the health status as measured by the VAS. After ozone therapy, we found a significant improvement in anxiety and depression measured by both the (i) HADS subscales and (ii) EQ-5D-5L questionnaire.ConclusionThe addition of ozone therapy for patients with refractory symptoms of cancer treatment and advanced chronic nononcologic diseases can decrease anxiety and depression severity levels. Additional, more focused studies are ongoing to provide the needed explanatory information for this finding.
Body-oriented interventions to promote preschoolers’ social–emotional competence: a quasi-experimental study
Authors: Dias Rodrigues Andreia , Marmeleira José , Pomar Clarinda , Lamy Elsa , Guerreiro Daniela , Veiga Guida 
Published: August 2023

IntroductionSocial–emotional competence is foundational to children’s health and well-being. Body-oriented interventions, such as relaxation or play based interventions, have been shown to promote social–emotional competence, however more studies are needed to better understand the specific benefits of each type of body-oriented approach.ObjectiveThe present study aimed to examine the chronic and the acute effects of three body-oriented intervention programs (loose parts play, relaxation and combining loose parts play and relaxation) on preschoolers’ social–emotional competence.MethodsA quasi-experimental study was carried out, including 62 preschoolers (4.44 ± 0.93 years) that were allocated into 4 groups: Loose Parts Play program (n = 17); Relaxation program (n = 17); Combined program (n = 13); and Waitlist Control Group (no intervention; n = 15). All three intervention programs had a 12-week duration, with biweekly sessions of 30-min, implemented in the preschool outdoors. To examine the chronic effects of the intervention programs, all instruments (parents’ and preschool teacher’s questionnaires, tasks and saliva) were collected at baseline and after the 12-week period. To examine the acute effects, saliva samples were collected immediately before and after the 1st and the 24th sessions, with a total of 4 collections per child.ResultsBoth loose parts play and relaxation interventions significantly improved (p &lt; 0.05) children’s positive emotion expression. Several within-groups changes were found for the Loose parts play, Relaxation and Combined programs.ConclusionBody-oriented interventions effectively promote preschoolers’ social–emotional competence.
Is melancholia a distinct syndrome? Recurrence, chronicity, and severity give evidence in the 50 year follow-up of the Lundby Study
Authors: Nöbbelin Linnéa , Bogren Mats , Mattisson Cecilia , Westling Sofie , Brådvik Louise 
Published: August 2023

IntroductionWhether melancholia is a distinct syndrome has long been debated. One aspect of a valid syndrome is whether it allows for determination of a prognosis. The aim of this study is to investigate the course of melancholic depression versus non-melancholic depression with a focus on: (i) time to and probability of recovery from the first depressive episode, (ii) time to and risk of the first recurrence, (iii) rate of recurrence, (iv) time with depression or antidepressant medication, and (v) suicide risk.MethodsThe Lundby Study is a longitudinal community study on mental health that followed a geographically defined population (N = 3,563) for up to 50 years, 1947–1997. Subjects with first onset depression were assessed as melancholic (N = 46) or non-melancholic (N = 381) using the DSM-IV melancholic specifier. These diagnoses were made in retrospect using all available information from semi-structured interviews by psychiatrists, key informants, registers, and patient records.ResultsWe found no significant difference between melancholic- and non-melancholic depression in time to and probability of recovery from the first depressive episode. The time to first recurrence was shorter in melancholic than in non-melancholic depression and the risk of first recurrence for the melancholic group was 2.77 (95% confidence interval [CI] 1.83–4.20) times the risk in the non-melancholic group. The median rate of recurrence was higher in the melancholic group, at 0.19 recurrences per year at risk (interquartile range [IQR] 0.08–0.47), compared to the non-melancholic group, at 0.10 recurrences per year at risk (IQR 0.05–0.21) (p &lt; 0.03). The median percentage of time being depressed or on antidepressant medication was higher in the melancholic group, 17% (IQR 3–20%), compared to the non-melancholic group, 8% (IQR 7–33%) (p &lt; 0.001). The risk of suicide was higher in the melancholic group, hazard ratio 4.13 (95% CI 1.49–11.48, p &lt; 0.01).DiscussionTo conclude, melancholic depression had a more recurrent, chronic, and severe course with a higher suicide risk than did non-melancholic depression in the Lundby population. Although our use of retrospective diagnosis might limit interpretation of results, the findings indicate that melancholia may be useful in determining prognosis and may be a valid psychopathological syndrome.
Pengembangan Game Edukasi Berhitung (GESIT) untuk Menstimulasi Kemampuan Berhitung Permulaan Anak Usia 5-6 Tahun
Authors: Nanda Novia Dilla Safitri  , Tomas Iriyanto  , Nur Anisa  
Published: August 2023

Beginning numeracy skills are the initial basic abilities that learn understanding related to counting objects, simple addition and subtraction. The aim of this research is to produce an educational game product that is appropriate, effective and efficient according to media experts, material experts and practitioners, to stimulate early numeracy skills in children aged 5-6 years. This type of research uses research and development (R&D) and the development model used is ADDIE (analysis, design, development, implementation and evaluation). The media validation test results were 85%, the material validation test results were 90%, then trials on class teachers were 78%, and small group trials obtained 90%, from the four results it can be concluded that the GESIT game is suitable for use by children aged 5-6 years . While the results of the non-parametric statistical test using the Wilcoxon test 0.002 (p-value) with a significance level of 0.05 which means (0.002 (p-value) <0.05) then Ha is accepted and Ho is rejected, namely the influence of the GESIT game on learning outcomes counting the beginning in children aged 5-6 years.
ABSTRAK
Kemampuan berhitung permulaan merupakan kemampuan dasar awal yang mempelajari pemahaman terkait dengan menghitung benda, penjumlahan dan pengurangan sederhana. Tujuan dari penelitian ini adalah untuk menghasilkan sebuah produk game edukasi yang layak, efektif dan efisien menurut ahli media, ahli materi dan praktisi, untuk menstimulasi kemampuan berhitung permulaan pada anak usia 5-6 tahun. Jenis penelitian ini menggunakan research and development (R&D) serta model pengembangan yang digunakan yaitu ADDIE (analysis, design, development, implementasion dan evaluation). Hasil uji validasi media 85%, hasil uji validasi materi 90%, kemudian uji coba terhadap guru kelas 78%, dan uji coba kelompok kecil memperoleh 90%, dari keempat hasil tersebut dapat disimpulkan bahwa game GESIT layak digunakan untuk anak usia 5-6 tahun. Sedangkan dari hasil uji statistik nonparametik menggunakan uji wilcoxon 0,002 (p-value) dengan taraf signifikansi sebesar 0,05 yang artinya (0,002 (p-value) < 0,05) maka Ha diterima dan Ho ditolak yaitu adanya pengaruh game GESIT terhadap hasil belajar berhitung permulaan pada anak usia 5-6 tahun.
Pengaruh Penerapan Model Pembelajaran Kooperatif Tipe Make a Match dan Minat Belajar terhadap Hasil Belajar Biologi Peserta Didik Kelas X MIPA SMA Negeri 4 Bantaeng
Authors: Sahodding Sahodding , Hala Yusminah , Palennari Muhiddin 
Published: August 2023

The study aims to examine (1) the learning outcomes based on the interests taught by using the Cooperative Learning Model of Make a Match type and the conventional learning, (2) the differences in learning outcomes based on the interests between those taught by using the Cooperative Learning Model of Make a Match type and the conventional one. This type of study is a true experimental research design using a 2x2 factorial design. The research population was all grade X MIPA at SMAN 4 Bantaeng for academic year 2021/2022 with 141 people. The sampling was conducted by using simple random sampling technique and the class selected was grade X MIPA 2. The hypothesis testing was conducted by using the SPSS 21.0 program with Ancova two way analysis. The results of the study reveal that (1) the learning outcomes based on the interests taught by using the Cooperative Learning Model of Make a Match type is better than students taught by using conventional learning model, (2) there is no significant difference in learning outcomes based on interests between those taught by using the Cooperative Learning Model of Make a Match type and the conventional learning model.