bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human REXO4 is Required for Cell Cycle Progression
Authors: Clutario Kevin M. , Abdusamad Mai , Ramirez Ivan , Rich Kayla J. , Gholkar Ankur A. , Zaragoza Julian , Torres Jorge Z. 
Published: January 2025

ABSTRACTHuman REXO4 is a poorly characterized exonuclease that is overexpressed in human cancers. To better understand the function of REXO4 and its relationship to cellular proliferation, we have undertaken multidisciplinary approaches to characterize its cell cycle phase-dependent subcellular localization and the cis determinants required for this localization, its importance to cell cycle progression and cell viability, its protein-protein association network, and its activity. We show that the localization of REXO4 to the nucleolus in interphase depends on an N-terminal nucleolar localization sequence and that its localization to the perichromosomal layer of mitotic chromosomes is dependent on Ki67. Depletion of REXO4 led to a G1/S cell cycle arrest, and reduced cell viability. REXO4 associated with ribosome components and other proteins involved in rRNA metabolism. We propose a model where REXO4 is important for proper rRNA processing, which is required for ribosome biogenesis, cell cycle progression, and proliferation.SIGNIFICANCE STATEMENTREXO4 is a putative RNA exonuclease with limited characterization. The authors used in silico, cell, and molecular biology approaches to characterize its localization, associations, regulation, and function.They found that during interphase, REXO4 localizes to the nucleolus through an N-terminal nucleolar localization sequence. Whereas during mitosis, REXO4 localized to the perichromosomal layer in a Ki67-dependent manner. REXO4 was required for proper cell cycle progression, and viability.These results indicated that REXO4 is important for regulating cell proliferation.
19S proteasome loss causes monopolar spindles through ubiquitin-independent KIF11 degradation
Authors: Marescal Océane , Cheeseman Iain M. 
Published: January 2025

AbstractTo direct regulated protein degradation, the 26S proteasome recognizes ubiquitinated substrates through its 19S particle and then degrades them in the 20S enzymatic core. Despite this close interdependency between proteasome subunits, we demonstrate that knockouts from different proteasome subcomplexes result in distinct highly cellular phenotypes. In particular, depletion of 19S PSMD lid proteins, but not that of other proteasome subunits, prevents bipolar spindle assembly during mitosis, resulting in a mitotic arrest. We find that the monopolar spindle phenotype is caused by ubiquitin- independent proteasomal degradation of the motor protein KIF11 upon loss of 19S proteins. Thus, negative regulation of 20S-mediated proteasome degradation is essential for mitotic progression and 19S and 20S proteasome components can function independently outside of the canonical 26S structure. This work reveals a role for the proteasome in spindle formation and identifies the effects of ubiquitin- independent degradation on cell cycle control.
WHITE-Net : White matter HyperIntensities Tissue Extraction using deep learning Network
Authors: Cathala Camille , Kherif Ferath , Thiran Jean-Philippe , Bussy Aurélie , Draganski Bogdan 
Published: January 2025

AbstractGiven the high prevalence of aging-associated cerebral small vessel disease in the general population, accurate detection of the related white matter hyperintensities (WMH) in large-scale magnetic resonance imaging (MRI) studies is of critical importance. The performance of currently available semi-automated and automated methods for WMH classification is hampered by their inherent dependence on MRI contrast parameters and long computational processing time. We sought to improve the accuracy and computational cost of automated WMH detection by creating a whole-brain deep learning-based framework: WHITE-Net. We use a 3D ResUNet architecture trained on manually segmented WMHs from fluid-attenuated inversion recovery MRI (n=141) and test its accuracy in a large-scale dataset (n=192). We demonstrate a good generalizability across WMH lesion loads, different MRI scanner vendors, field strengths, imaging protocols, and MR contrasts. The comparison to existing WMH segmentation tools shows a similar to superior accuracy performance at significantly lower computational cost. WHITE-Net tool performance makes it well-suited for application to large-scale MRI datasets, enabling the study of the aging brain while offering the advantage of detecting early or subtle WMH changes often missed by other methods.
Quantifying potential immortal time bias in observational studies in acute severe infection
Authors: Yates Tom A. , Parks Tom , Dodd Peter J. 
Published: January 2025

KEY POINTSImmortal time bias exaggerates estimates of treatment efficacy in naïve analyses of observational data. We developed a tool to estimate the extent of this bias. The benefits of giving intravenous immunoglobulin in streptococcal toxic shock syndrome have likely been overstatedBackgroundImmortal time bias is a spurious or exaggerated protective association that commonly arises in naive analyses of observational data. It occurs when people receive the intervention because they survive, rather than survive because they received the intervention. Studies in conditions with substantial early mortality, such as acute severe infections, are particularly vulnerable. The bias can be avoided by fitting the intervention as a time-varying exposure.MethodsWe developed IMMORTOOL, an R package accessible via a user-friendly web interface. This tool will estimate the potential for immortal time bias using empiric or assumed data on the distributions of time to intervention and time to event. Assumptions are that no other biases are present and that the intervention does not impact the outcome. The tool was benchmarked using studies presenting both naive analyses and analyses with the intervention fit as a time-varying exposure. We applied IMMORTOOL to a set of influential observational studies that used naive analyses when estimating the impact of polyclonal intravenous immunoglobulin (IVIG) on survival in streptococcal toxic shock syndrome (STSS).ResultsIMMORTOOL demonstrated that published estimates suggesting a survival advantage from giving IVIG in STSS are explained, at least in part, by immortal time bias.ConclusionsIMMORTOOL can quantify the potential for immortal time bias in observational analyses. This may help readers interrogate published studies. We do not advocate IMMORTOOL being used to justify naive analyses where the intervention could be fit as a time-varying exposure. To what extent giving IVIG in STSS improves survival remains uncertain.
Dark Matter Search Results from
1.54  Tonne·Year
Exposure of PandaX-4T
Authors: Bo Zihao , Chen Wei , Chen Xun , Chen Yunhua , Cheng Zhaokan , Cui Xiangyi , Fan Yingjie , Fang Deqing , Gao Zhixing , Geng Lisheng , Giboni Karl , Guo Xunan , Guo Xuyuan , Guo Zichao , Han Chencheng , Han Ke , He Changda , He Jinrong , Huang Di , Huang Houqi , Huang Junting , Hou Ruquan , Hou Yu , Ji Xiangdong , Ji Xiangpan , Ju Yonglin , Li Chenxiang , Li Jiafu , Li Mingchuan , Li Shuaijie , Li Tao , Li Zhiyuan , Lin Qing , Liu Jianglai , Lu Congcong , Lu Xiaoying , Luo Lingyin , Luo Yunyang , Ma Wenbo , Ma Yugang , Mao Yajun , Meng Yue , Ning Xuyang , Pang Binyu , Qi Ningchun , Qian Zhicheng , Ren Xiangxiang , Shan Dong , Shang Xiaofeng , Shao Xiyuan , Shen Guofang , Shen Manbin , Sun Wenliang , Tao Yi , Wang Anqing , Wang Guanbo , Wang Hao , Wang Jiamin , Wang Lei , Wang Meng , Wang Qiuhong , Wang Shaobo , Wang Siguang , Wang Wei , Wang Xiuli , Wang Xu , Wang Zhou , Wei Yuehuan , Wu Weihao , Wu Yuan , Xiao Mengjiao , Xiao Xiang , Xiong Kaizhi , Xu Yifan , Yao Shunyu , Yan Binbin , Yan Xiyu , Yang Yong , Ye Peihua , Yu Chunxu , Yuan Ying , Yuan Zhe , Yun Youhui , Zeng Xinning , Zhang Minzhen , Zhang Peng , Zhang Shibo , Zhang Shu , Zhang Tao , Zhang Wei , Zhang Yang , Zhang Yingxin , Zhang Yuanyuan , Zhao Li , Zhou Jifang , Zhou Jiaxu , Zhou Jiayi , Zhou Ning , Zhou Xiaopeng , Zhou Yubo , Zhou Zhizhen ,   PandaX Collaboration
Published: January 2025

In this Letter, we report the dark matter search results from the commissioning run (Run0) and the first science run (Run1) of the PandaX-4T experiment. The two datasets were processed with a unified procedure, with the Run1 data treated blindly. The data processing is improved compared to previous work, unifying the low-level signal reconstruction in a wide energy range up to 120 keV. With a total exposure of 1.54  tonne·year, no significant excess of nuclear recoil events is found. The lowest 90% confidence level exclusion on the spin-independent cross section is 1.6×10−47  cm2 at a dark matter mass of 40  GeV/c2. Our results represent the most stringent constraint for a dark matter mass above 100  GeV/c2.

Published by the American Physical Society
2025
Effect of ultra-high aspect ratio wings and distributed propulsion on the viability of fully electric regional aircraft
Authors: Gilbrook Aaron , Ma Yiyuan , Elham Ali 
Published: January 2025

Purpose
Revolutionary advances in aircraft technology and performance are needed for fuel-efficient and sustainable next-generation air transportation. This study aims to explore the influence of integrating distributed propulsion with ultra-high aspect ratio (AR) wings (UHARW) on the realization of fully electric regional aviation.

Design/methodology/approach
The strut-braced wing (SBW) configuration is advantageous for UHARW due to its additional support. A conceptual design and analysis framework for UHARW aircraft with SBW and distributed propulsion configurations is developed by enhancing and integrating several methods and tools. Based on the mission profile and top-level requirements, a fully electric regional SBW aircraft with distributed propulsion is designed and analyzed.

Findings
Integrating distributed propulsion with a high AR SBW configuration in a fully electric regional aircraft results in notable energy efficiencies. The design achieves a 2.85% increase in the lift-to-drag ratio and a 2.62% reduction in drag during cruise. Sensitivity analysis indicates optimal performance with an AR up to 22, beyond which structural weight penalties diminish benefits. The aircraft’s energy efficiency improves by 9.9% during climb and 6% during cruise, highlighting the importance of propulsion integration.

Practical implications
This research provides a viable framework for designing fully electric regional aircraft by integrating distributed propulsion with high AR SBW configurations. The findings provide practical guidance for enhancing energy efficiency and reducing structural weight, supporting the development of more sustainable and efficient aircraft designs.

Social implications
The findings support the development of sustainable aviation technologies, potentially reducing the environmental footprint of regional air travel and contributing to global efforts toward greener transportation solutions.

Originality/value
This study presents a comprehensive methodology for designing and analyzing UHARW aircraft with SBW and distributed propulsion, contributing to the feasibility assessment of fully electric regional aviation.
Ownership with a green twist: the role of top managers in driving environmental innovation
Authors: Yue Shanshan , Bajuri Norkhairul Hafiz B. , Khatib Saleh F.A. , Alshareef Mohammed Naif 
Published: January 2025

PurposeThis study aims to explore the relationship between managerial ownership and environmental innovation, particularly focusing on the impact of minority shareholder protection within the context of China’s A-share listed companies.Design/methodology/approachThe study employs a fixed effect model over a decade-long sample, analysing secondary data from nonfinancial Chinese A-share firms. The two-stage least squares (2SLS) method is adopted to address endogeneity concerns.FindingsThe results demonstrate a significant positive influence of managerial ownership on environmental innovation, suggesting that top managers who have a say in the boardroom are inclined towards sustainable development. The presence of minority shareholders' protection positively moderates this relationship, underlining their roles in fostering environmentally friendly development. The subsample analysis showed that these relationships vary between state-owned enterprises (SOEs) and non-SOEs. It also differs between heavily and lightly polluting industries, which indicates that it is not enough to just have internal self-management, and more external pressure is necessary in heavily polluting industries.Research limitations/implicationsOur study underscores the importance for managers to recognize the potential of aligning their ownership interests with environmental objectives. Companies can enhance their commitment to sustainability by fostering an internal environment that supports minority shareholder rights.Originality/valueThis study specifically focuses on the role of top managers and minority shareholders, providing new empirical evidence on how their influence can drive sustainable development initiatives. It is also among the few studies that differentiate between firm characteristics and pollution intensity, which provides valuable insights into how the impact of managerial ownership and minority shareholder protection varies across different contexts.
Learning on the go! Increased job crafting in healthcare sector
Authors: Tripathy Saswati , Padhi Mousumi , Pattnaik Subhra 
Published: January 2025

Purpose
The purpose is to explore the job crafting behavior that arises as a consequence of rapid learning.

Design/methodology/approach
Focused group discussion (FGDs) and in-depth interviews were conducted with healthcare professionals in three hospitals in India. Data was collected between July 2021 and February 2022 during second wave of pandemic.

Findings
It was found that healthcare professionals exhibited task, relational and cognitive crafting of the job as an outcome of instant contextual learning and crafted their tasks, relations and cognitive abilities to take proactive measures, related to patient and attendant care.

Research limitations/implications
Due to prevalence of COVID-19 protocols wider sampling was not feasible. A comparative study with a control group not having underwent rapid learning would have brought out final nuance.

Practical implications
This study highlights the role mentoring, job shadowing, workshop, simulation as means of enhancing rapid learning.

Social implications
In crisis situations how extra manpower can be successfully deployed by way of capability enhancement mechanism and this will lead to effective handling of emergency situations in future.

Originality/value
This paper rests on an under-researched area at the junction of crisis management, organizational learning, and job crafting. It’s different from the phenomenon of usual long term learning and gradual job crafting.
Interweaving academic insights: advancing university knowledge management through a strategic data fabric framework
Authors: Nguyen Thi Kim Lan , Nguyen Hoang Son , Nguyen Hoa N. 
Published: January 2025

Purpose
Effective knowledge management in large academic institutions is crucial for fostering innovation and improving educational practices. However, these institutions often face challenges, such as data fragmentation, siloed information systems and the complexity of integrating different data sources from various departments with complex hierarchical structures. To address these problems, the authors proposed a data fabric strategic framework that improves and enhances knowledge management by leveraging ontologies and knowledge graphs. This study aims to investigate the potential of knowledge graphs, ontological knowledge modelling and knowledge representation to improve knowledge management in large academic institutions. It also describes how technology can enhance knowledge accessibility and exchanges and improve decision-making processes based on insights from complex educational systems.

Design/methodology/approach
This study uses coordination theory as a foundational framework to analyse intricate data systems in preparation for constructing, the Wizard of Oz method to facilitate the systematic organisation and management of information and the execution of an ontology-based data fabric framework and knowledge graphs. The authors propose a data fabric strategic framework aimed at improving knowledge management by leveraging ontologies and knowledge graphs.

Findings
The final evaluation demonstrates that this approach effectively breaks down data silos, promotes research collaboration and improves decision-making processes in large academic settings, offering solution-oriented data fabric technologies applicable to universities and university federations globally.

Practical implications
The proposed system provides a more efficient way of managing and connecting fragmented academic resources, improving accessibility for both learners and educators. By interconnecting and streaming knowledge management process, the system can reduce not only operational costs but also expenses on doing scientific research.

Originality/value
Academic institutions prioritise time efficiency when acquiring vital data for improved scientific results. This emphasis extends beyond data governance to focus on how collective intelligence might improve organisational performance. The academic community has enhanced data utilisation through the implementation of data fabric technologies to improve data accessibility and data line tracking.
Is career development resource always perceived good in SMEs? A comparative analysis of employment
Authors: Joo Jaehong , Kim Dahyun , Song Ji Hoon , Yoo Myunghyun 
Published: January 2025

Purpose
This study aims to examine whether employees perceive career development resources the same and to identify which factors affect these perceptions differently, considering their employment type within small- and medium-sized enterprises in South Korea.

Design/methodology/approach
This study used a quantitative methodology to explore the differential perceptions of the relationship between organizational support practices, person–job fit and employee attitudes. The authors used a sample of 1,560 employees comparing the responses of Generation Z employees across employment type.

Findings
This study delved into organizational factors such as the support system and fairness in performance appraisal, alongside individual factors like person–job fit according to employment type. It enabled to ascertain the relative significance of these factors in shaping employees’ views on career development.

Originality/value
This study enriches the discussion on the specific career development traits of this demographic. This study also discusses theoretical and practical implications for human resource development, emphasizing strategic interventions that enable employees to actively manage their careers and foster a positive work environment.
Usability evaluation of academic library websites: a systematic literature review
Authors: Jilani Malik Asif , Sheikh Arslan , Shah Faiz Ali , Saqlain Syed Muhammad 
Published: January 2025

Purpose
This study aims to systematically review the published literature on the topic of academic library website usability evaluation. It determines the most significant subattributes in the usability evaluation of academic library websites. The study also looks at the metrics that have been used to evaluate the usability of academic library websites. Then, it identifies the most significant usability evaluation method (UEM) that has been discussed in the literature. Lastly, it identifies the research gaps in the literature regarding the proposed approaches to usability evaluation of academic library websites.

Design/methodology/approach
In this systematic literature review (SLR), the research conducted in the area of usability evaluation of academic library websites from 1995 to 2023 was reviewed.

Findings
The results of this study disclose that “effectiveness” is the most significant usability subattribute in the context of usability evaluation of academic library websites. Furthermore, “user testing” is the most significant UEM that has been applied in most of the primary studies. Some of the metrics used for the measurement of effectiveness were user preference, error rate and number of correct answers. Similarly, some of the metrics used, for efficiency, were response time, click count, time on task, logical information architecture and efficient information retrieval and so on. The common research gap in the reviewed literature is a lack of a generalized framework applicable to any academic library website for its usability evaluation.

Practical implications
This study is useful for library website developers to better understand the required features of a library website.

Originality/value
This is the first SLR on the topic of academic libraries’ website usability evaluation.
The importance weights of Generation Z’s demand for product innovation in single-detached houses in Thailand, using a modified analytical hierarchy process (M-AHP)
Authors: Nititerapad Chunyarat , Chetsurakul Sorranut 
Published: January 2025

Purpose
The purpose of this study is to examine the importance weights of the demand for product innovation, specifically in single-detached house among Generation Z in Thailand.

Design/methodology/approach
The significant quantitative research, analyzed using a modified analytical hierarchy process, involved a total of 400 Generation Z responses. These responses were categorized by two levels of house prices: up to US$150,000 and above US$150,000, with 200 people per price level. The data were then analyzed with Likert-scale questionnaire through the modified analytical hierarchy process model, providing valuable insights into Generation Z’s housing preferences.

Findings
The results of this study indicate that the sample group with house prices up to US$150,000 prioritizes innovation that provides convenience, while the groups with house prices above US$150,000 prioritize security innovations. Generation Z’s top three innovations with highest demand in single-detach houses are related to security innovation.

Research limitations/implications
This study is advantageous for developers which can be used to plan and design homes for Generation Z customers.

Originality/value
To the best of the authors’ knowledge, this research is the first to determine the importance weights of Generation Z’s demand for product innovation of single-detached houses in Thailand.