bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational Evaluation of Punica granatum Leaf Phytochemicals against Multi-drug Resistant E. coli: Molecular Docking, ADMET, MD Simulation, and DFT Studies
Authors: Mishra Shivam , Modanwal Shristi , Kumar Prabhat , Mishra Ashutosh , Mishra Nidhi 
Published: January 2025

Introduction:
Multidrug-resistant (MDR) E. coli presents a significant challenge in
clinical settings, necessitating the exploration of novel therapeutic agents. Phytochemicals from
Punica granatum (pomegranate) leaves have shown potential antibacterial properties. This study
aims to identify and evaluate the efficacy of these phytochemicals against MDR E. coli.

Objectives:
This study aims to identify and evaluate the efficacy of most potential phytochemical
of Punica granatum leaf against MDR E. coli. through molecular docking, adme, toxicity,
molecular dynamic simulation, MMPBSA and DFT approaches.

Methods:
We performed molecular docking of 11 phytochemicals from the IMPPAT database
with four MDR E. coli targets: 1AJ6, 1FJ8, 4BJP, and 6BU3. Granatin B demonstrated the best
binding affinity and was further analyzed. ADME (Absorption, Distribution, Metabolism, and
Excretion) and toxicity analyses were conducted to assess its pharmacokinetic properties and
safety profile. Molecular Dynamics (MD) simulations were performed to evaluate the stability
of Granatin B with the targets. Finally, density functional theory (DFT) analysis was carried out
to understand the electronic properties and reactivity of Granatin B.

Results:
Granatin B exhibited the highest binding affinity among the 11 phytochemicals, indicating
strong potential as an inhibitor of MDR E. coli. ADME analysis revealed favorable
pharmacokinetic properties and toxicity analysis confirmed that Granatin B is non-toxic. MD
simulations showed stable interactions between Granatin B and all four targets. DFT analysis
provided insights into the electronic properties and reactive sites of Granatin B, supporting its
potential mechanism of action.

result:
Granatin B exhibited the highest binding affinity among the 11 phytochemicals, indicating strong potential as an inhibitor of MDR E. coli. ADME analysis revealed favorable pharmacokinetic properties, and toxicity analysis confirmed that Granatin B is non-toxic. MD simulations showed stable interactions between Granatin B and all four targets. DFT analysis provided insights into the electronic properties and reactive sites of Granatin B, supporting its potential mechanism of action.

Conclusion:
Granatin B from Punica granatum leaves is a promising candidate for treating
MDR E. coli infections. The integration of molecular docking, ADME, toxicity, MD simulations,
and DFT analysis underscores its therapeutic potential and paves the way for further experimental
validation and development as a novel antibacterial agent.
Effect of Self-management Intervention on Improvement of Quality of Life in Chronic Kidney Disease Patients: A Scoping Review
Authors: Pal Suchitra , Panduragan Santhna Letchmi , Said Faridah Mohd , Poddar Sandeep 
Published: January 2025

Background
Chronic Kidney Disease (CKD) presents significant challenges globally, affecting health-related outcomes, quality of life (QoL), and healthcare expenditure. Self-management interventions are currently gaining importance as a means to empower the patients to manage their disease by themselves. However, currently there is a paucity of evidence evaluating its overall and proven role in patients with CKD. With this goal, we have designed this review to have a consensus on this aspect.

Objective
The objective of this study is to determine the effect of self-management interventions among patients with CKD who are not on renal replacement therapy (RRT).

Methods
This review was performed complying with the guideline set by the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews (PRISMA-ScR). Literature search was conducted using PubMed, Scopus, and ProQuest databases using the keywords “Chronic Kidney Disease”, “self-management intervention” and “Quality of Life”. Articles on patients with CKD not requiring RRT, published between January 2018 and December 2023, were included in this review. Articles such as dissertations, review articles, non-interventional studies, and those written in languages other than English were excluded. Out of the initially screened 17, 279 studies, 23 studies (including 3, 345 patients aged between 18 and 81 years) fulfilled our inclusion criteria were finally included in this review. Quality assessment and data extraction were conducted using Critical Appraisal Skills Program (CASP) and Mixed Method Appraisal tool (MMAT).

Results
Overall use of self-management interventions led to improvements in diet quality, psychological health, Health Related Quality of Life (HRQoL), self-management behaviors, and physiological and biochemical markers in patients with CKD. Nurse-led interventions, multidisciplinary approaches, and virtual care were found to be effective in enhancing self-efficacy and QoL.

Conclusion
Self-management interventions can significantly improve various aspects of health and QoL in CKD patients. Nurse-led and multidisciplinary approaches, as well as virtual care, are found to be effective strategies in this subset of patients who do not require RRT. Further research is needed to emphasize evidence and refine the interventions for broader application.
Thymol and Carvacrol as Potential Tocolytic and Anti-inflammatory Agents in Pregnant Rat Uterus
Authors: Muñoz-Pérez Victor Manuel , Pérez-Sánchez Aurora , Salas-Casas A Andrés , Ortíz Mario I. 
Published: January 2025

Introduction:
This work aimed to evaluate the anti-inflammatory and myorelaxant effect of thymol (TM) and carvacrol (CAR) in the pregnant rat uterus. Both
compounds exhibit considerable antimicrobial, antispasmodic, and anti-inflammatory effects and due to these properties, they were studied in this
in vitro model of premature birth induced by infection.

Method:
All uterine tissues were studied in uterine contraction tests to determine the inhibitory effect of TM, CAR (10, 56, 100, 150, and 230 μM), and
nifedipine (a calcium channel antagonist) on phasic and tonic contraction induced by electro- and pharmacomechanical stimuli. The quantitative
determination of cyclic adenosine monophosphate (cAMP) induced by TM and CAR in the uterine lysate was carried out by ELISA. For the
determination of the anti-inflammatory effect of TM, the pro-inflammatory cytokine, interleukin (IL)-1β, in uterine samples stimulated with
lipopolysaccharide (LPS) was measured. Forskolin (FSK) was used as a positive control to evaluate the cAMP and cytokine levels. TM, CAR, and
nifedipine inhibited the uterine contractions at the highest concentration level, however, nifedipine was the most equipotent (p<0.05). In addition,
TM and CAR did not increase the intracellular cAMP production in comparison with FSK (p<0.05). However, both compounds were able to
decrease the LPS-induced production in a concentration-dependent manner that was considered statistically significant (p>0.05).

Results:
Finally, both the anti-inflammatory and uterine relaxing effects induced by TM and CAR were neither associated with the increase in cAMP levels
nor with the production of IL-1β in pregnant rat uterine samples. Therefore, TM and CAR can be considered as alternative adjuvants for the
treatment of infection-induced preterm labor. Before the in vitro experiments, an in-silico analysis was conducted using the Expaisy online server
to evaluate the biological effects of thymol on uterine contraction.

Conclusion:
It is crucial to know the interaction and identification of genes encoding the Voltage-dependent L-type calcium channel subunit alpha-1C proteins,
because of the functional relationship it may have in the inhibition of the uterine contraction. These properties place TM as a potentially safe and
effective adjuvant agent in cases of preterm birth, an area of pharmacological treatment that requires urgent improvement.
Understanding COVID-19 Vaccine Hesitancy in Nigeria Through University Community Lens
Authors: Madu Cajethan Okechukwu 
Published: January 2025

It is widely acknowledged that vaccination represents one of the greatest advances in public health in human history. Nonetheless, vaccine rejection or hesitancy is a public health issue that has continuously thwarted coordinated attempts by health officials to stop the spread of infectious diseases like the Coronavirus in Nigeria. It is critical to assess public perception, which will encourage vaccine acceptance through focused initiatives. Therefore, this study assesses vaccination reluctance among the Benue State University student community. A cross-sectional descriptive design was used in the study. A questionnaire was distributed to 150 participants, selected through the convenience sample technique. SPSS was used to enter and analyse the data. Eighty-seven percent of the respondents were between their first and third years, and the majority (63%) were over 18-30. Only 68% of the respondents thought the virus was real.Additionally, none of the students had a favourable disposition towards the vaccination. The respondents cited fear of vaccine side effects (46.2%), distrust of the government (33.9%), vaccine efficacy (12.5%), and a variety of mystical possibilities (7.4%) as the major causative factors behind their hesitation to receive the vaccination. Available data show a serious communication breakdown between the respondents and the regional health authority. To improve public acceptance of the COVID-19 vaccine, broad and focused public health promotion initiatives are needed to alleviate some public concerns.
Enseñanza del pensamiento sistémico de la Tierra. Evidencias del aprendizaje activo y propuesta de un modelo De capítulo para el “Atlas Interdisciplinario de México”
Authors: Becerra-Torres Eduardo , Bravo-Pérez Oscar 
Published: January 2025

La Tierra, la sociedad y el ambiente están encarando en los últimos años fuertes crisis climáticas, energéticas, alimenticias e hídricas. En la formación académica esta circunstancia obliga a los docentes a formar profesionales capaces de entender la importancia de la interdisciplinariedad y la transdisciplinariedad y de la aplicación de los conocimientos que con ellas se adquieren en la resolución de problemas multivariables en sistemas complejos. La enseñanza de las Ciencias de la Tierra debe implementar técnicas de docencia innovadoras y estimulantes que permitan desarrollar el Pensamiento Sistémico de la Tierra (PST). Los docentes que abordan los temas el Sistema Tierra deben tener claro que el estudiantado está conformado por personas con perfiles heterogéneos y académicos diversos y, en consecuencia, utilizar las técnicas de enseñanzaaprendizaje tradicionales, discursivas y unidireccionales reduce las posibilidades de adquirir habilidades de orden superior como el análisis, la síntesis y la resolución de problemas. En este trabajo presentamos un modelo de capítulo para el “Atlas Interdisciplinario de México” utilizando datos de un estudio sobre la Cuenca de Serdán-Oriental con actividades conducidas que permiten el ejercicio del pensamiento sistémico transdiciplinario con vistas a la formación de profesionales capacitados para contribuir a la solución de los problemas globales que enfrenta la sociedad. Asimismo, presentamos los resultados de la intervención educativa durante el 2022 que demuestran que la aplicación de este modelo de enseñanza estimula el aprendizaje autónomo y la resolución de problemas complejos, con miras a cumplir el objetivo de una educación de calidad y la reducción de desigualdades.
Quiñónez de Huizar, Francisco Rubén, Sistema Jurisprudencia y el precedente obligatorio en México, México, Editorial Ubijus, 2023
Authors: Orduña Trujillo Eva Leticia 
Published: January 2025

La obra se aboca al análisis del sistema jurisprudencial en su sentido amplio: conceptual, histórico y técnico jurídico. En particular estudia el sistema jurisprudencial de México y la reforma realizada en 2021 al Poder Judicial Federal. En este último sentido, toma en cuenta la importancia y alcances del precedente obligatorio. El libro se compone de ocho capítulos: 1) Jurisprudencia y sistema jurídico, 2) La jurisprudencia en el derecho continental y en el common law, 3) Los orígenes del precedente judicial en México, 3) la jurisprudencia histórica, 4) El sistema de precedentes en la constitución de 1917, 5) La jurisprudencia vigente de 1919 a 2021, 6) La jurisprudencia en el sistema jurídico mexicano, 7) La naturaleza de la jurisprudencia, el nuevo paradigma de la jurisprudencia, 8) Elaboración y publicación de las tesis jurisprudenciales.
Procesiones festivas de la Compañía de Jesús en Tunja, Nuevo Reino de Granada, siglos XVII y XVIII
Authors: Martínez Martín Abel Fernando , Otálora Cascante Andrés Ricardo 
Published: January 2025

Este artículo, a partir de fuentes primarias, aborda las procesiones festivas barrocas más importantes de la Compañía de Jesús en Tunja, Nuevo Reino de Granada, desde la instalación del colegio y noviciado a inicios del siglo XVII hasta el siglo XVIII. La fiesta del Nombre de Jesús, unida a la de la Circuncisión, se realizaba a inicios del año por parte de la cofradía de indios y negros. Tras la beatificación de Francisco de Borja en el siglo XVII y los milagros de un desaparecido cuadro que lo representaba en Chitagoto, jurisdicción de Tunja, se instituyeron la fiesta y el voto en honor al abogado y patrón jurado de los terremotos, las sequías y los partos difíciles en Santafé y Tunja. Tras la expulsión de la Compañía de Jesús, desaparecieron estas procesiones festivas barrocas.
The Legal Theory of Investment Regimes
Authors: Lapteva A. M. 
Published: January 2025

This article is devoted to identify the features of the legal regulation of investment activity from the point of view of the concept legal regime. It should be stressed that such type the investment research is shown us the specific it’s regulation, the ratio of imperativeness and dispositivity and also the subjects activity level of the investment.The article analyzes and systematizes the doctrinal point of view on the concept of “legal regime”, it’s features and structure. The author’s definition of the investment regime is formulated, by which it is proposed to understand the procedure for regulating investment activity, expressed in a set of legal means characterizing a combination of interacting permits, prohibitions, as well as positive obligations and creating a special focus on regulating investment activity. The investment regime, according to the author, is a kind of legal regime.
Effect of orthodontic treatment on traumatized teeth treated by regenerative endodontic procedure
Authors: Yoshpe Margarita , Kaufman Arieh Y. , Einy Shmuel 
Published: January 2025

ABSTRACT

Objectives
To evaluate the effect of orthodontic movement on traumatized teeth treated with the regenerative endodontic procedure (REP).

Materials and Methods
The increase of the radiographic root area (RRA) of each REP tooth was measured at each follow-up visit after the end of orthodontic treatment. The study included two experimental groups of patients aged 7–17 with REP-treated teeth. The Ortho REP group consisted of eight patients who underwent orthodontic treatment, whereas the second group (no Ortho REP group) included seven patients who did not receive orthodontic treatment. The control groups comprised the same patients and their homologous or adjacent healthy teeth that did not undergo REP treatment.

Results
Orthodontic treatment did not negatively affect root development of immature, traumatized REP-treated teeth during the treatment or retention periods. Additionally, the increase in RRA in regenerated teeth was age-dependent, with the greatest RRA increase in young patients.

Conclusions
Close collaborative endodontic-orthodontic follow-up is recommended to ensure favorable results. The findings suggest that REP-treated teeth may undergo orthodontic treatment without adverse effects.
A USUCAPIÃO ESPECIAL URBANA DE NATUREZA MISTA: MORADIA E COMÉRCIO. PRECEDENTES DO SUPERIOR TRIBUNAL DE JUSTIÇA: ANÁLISE DO CASO À LUZ DA TEORIA DE NEIL MACCORMICK E O PRINCÍPIO DA VALORIZAÇÃO DO TRABALHO HUMANO
Authors: Lisboa José Herbert Luna 
Published: January 2025

A usucapião especial urbana insere-se no artigo 183 da Constituição Federal, no Estatuto da Cidade e no Código Civil. Os requisitos legais de natureza temporal, metragem, animus domini, posse mansa e pacífica, uso do imóvel como moradia e não possuir outro imóvel devem estar devidamente configurados para o seu reconhecimento. O presente trabalho objetiva analisar a decisão da Terceira Turma do Superior Tribunal de Justiça, no Recurso Especial nº 1.777.404/TO, que acolheu pretensão de usucapião de imóvel com destinação mista, uma vez que o bem tanto servia de moradia como local para pequena atividade comercial da família. Intenciona-se, neste artigo, abrir o debate sobre a importância desta decisão à luz do princípio constitucional da valorização social do trabalho humano, insculpido no art.1º e art.170, caput, da Constituição Federal, integrante do próprio valor supremo, que é a dignidade da pessoa humana. O presente estudo conduziu-se, metodologicamente, por meio da pesquisa bibliográfica e jurisprudencial, com foco na Teoria de Neil MacCormick a respeito da dupla função do processo, no sentido de solucionar conflitos e conferir sentido ao Direito.
Penggunaan Metode Arkeologi Foucauldian untuk Studi-Studi Media
Authors: Listiorini Dina 
Published: January 2025

This article aims to explain one of the Foucauldian discourse methods in studying media phenomena and elaborating communication artifacts or archives, namely archaeology. The article is based on a literature review that systematically integrates, analyses, and elucidates the presentation of the Foucauldian archaeological method. The archaeological concepts explored include rupture, breaks, discontinuity, threshold, limit, series, mutation, and transformation, all of which highlight the formation of marginal and forgotten discourses (or groups). To achieve this, a multilevel analysis is required at the micro, meso, and macro levels, grounded in concepts and methods that are informed by the historicity of discursive statements.
Evaluasi Pelaksanaan Program Rasailah Daku dalam Mengatasi Permasalahan Anak Jalanan oleh Dinas Sosial Kota Padang
Authors: Dwi Putri Rini , Mubarak Adil 
Published: January 2025

This study aims to determine the performance of the Rasailah Daku Program implemented by the Padang City Social Service. The research method used in this study is a descriptive qualitative method. The theory used is the theory of William N. Dunn about program evaluation indicators, namely: 1) Effectiveness; 2) Efficiency; 3) Adequacy; 4) Equity; 5) Responsiveness; and 6) Accuracy. Data were obtained through interviews, observations, and documentation. The results of the study indicate that the implementation of the Rasailah Daku Program has been effective in reducing the growth rate of street children in Padang City, but the objectives of the program implementation have not been optimal because program participants have returned to their activities on the streets.
System that Facilitates Communication for People With Speech Difficulties With Artificial Intelligence Techniques
Authors: Cruz-Guerrero René , Simón-Marmolejo Isaías , Hernández Elias Ruíz , Fragoso Karina Gutierrez 
Published: January 2025

Objective: To develop a communication system for people with speech difficulties that allows them to express their needs by issuing instructions to the computer with minimal eye blinks, using a model created with MediaPipe and Deep Learning techniques.

Theoretical Framework: The research is based on concepts of eye position tracking, convolutional networks and media pipe technology, with a focus on applying it to the communication needs of people with speech difficulties.

Method: Qualitative and exploratory study, convolutional networks and media pipe techniques were used. To create the dataset, web scraping techniques were combined with manual image collection, the model was trained by comparing the performance of two CNN architectures.

Results and Discussion: The incorporation of AI in the eye blink detection process is relatively recent, with more publications since 2020. It was found that the system is capable of processing facial gestures in real time with an average delay of 0.5 seconds, users reported improvements in their ability to communicate independently and reducing the effort their relatives had to make to interpret their needs, an accuracy of 94.5% was achieved in standard lighting conditions and 92% in variable conditions.

Research Implications: The research reveals how AI with the incorporation of continuously emerging methods can improve the task of detecting images for eye tracking, obtaining increasingly better results in precision.

Originality/Value: The application of emerging AI techniques in eye tracking to apply it in the development of a system that helps people with speech problems communicate.
ИНТЕЛЛЕКТУАЛЬНАЯ СИСТЕМА ФИЛЬТРАЦИИ НЕЖЕЛАТЕЛЬНОЙ ИНФОРМАЦИИ НА ОСНОВЕ ГЛУБОКОГО ОБУЧЕНИЯ
Authors: ВЛАСЮК Н А. , КАЛКОВ Д Ю. , ТОЛСТЫХ М Ю. 
Published: January 2025

Рассматривается применение технологий искусственного интеллекта для решения задачи фильтрации спам-сообщений. Основное внимание уделяется разработке системы, способной автоматически классифицировать текстовые данные на спам и не спам, используя методы глубокого обучения. Описывается процесс подготовки и предобработки данных, включающий очистку, балансировку классов и преобразование текста в подходящий для обучения формат. Анализ полученных результатов демонстрирует высокую точность и эффективность предложенной системы в задаче фильтрации спама. Подход может быть применен в областях, где требуется обработка и анализ больших объемов текстовой информации.
The application of artificial intelligence technologies to solve the problem of filtering spam messages is considered. The focus is on developing a system that can automatically classify text data into spam and non-spam using deep learning techniques. The process of preparing and preprocessing data is described, including cleaning, class balancing, and converting text into a format suitable for training. Analysis of the results obtained demonstrates high accuracy and efficiency.
ОЦЕНКИ ОТДЕЛЬНЫХ АСПЕКТОВ СОЦИАЛЬНО-ЭКОНОМИЧЕСКОЙ СИТУАЦИИ НА СЕВЕРЕ РФ И В РОССИЙСКОЙ АРКТИКЕ В УСЛОВИЯХ ГЛОБАЛЬНЫХ ВЫЗОВОВ И РИСКОВ
Authors: Гущина И.А. , Кондратович Д.Л. , Положенцева О.А. 
Published: January 2025

В основе данной статьи результаты многолетних исследований условий и факторов социально-экономического развития местных сообществ северных и арктических регионов РФ. Целью работы является определение степени влияния и возможностей снижения негативных последствий антироссийских санкций, включая импортозамещение, на процессы социально-экономического развития муниципальных образований северных и арктических регионов РФ в условиях расширения глобальной конфронтации и связанных с этим социальных и экономических рисков. Использован метод социологического анализа: по результатам трех экспертных опросов в 2022-2024 гг., на основе экспертных оценок представителей муниципальной власти указанных регионов и ученых, занимающихся исследованиями в социально- экономической сфере, определены направления экономической деятельности, понесшие, в той или иной степени, ущерб в результате санкционного давления; определены оценки успешности решения вопросов импортозамещения. Выявлено снижение изначально негативных ожиданий, зафиксированных по результатам экспертных опросов предыдущих лет, по таким показателям как рост цен, ухудшение качества и уровня жизни населения, сокращение ассортимента различных видов продукции. Показана возможность использования экспертных оценочных мнений при разработке и корректировке муниципальных и региональных планов и программ развития.