bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the Second Victim Support Program to the Just Culture Perception among Nurses
Authors: Logroño Kenneth Jun 
Published: February 2023

Abstract
Aim
Assess the impact of the second victim support program to the just culture perception of nurses.
Method
A descriptive, cross-sectional study using the validated Just Culture Assessment Tool (JCAT) conducted last November 2020 to December 2020 in a large referral hospital in the Middle East. The total response rate was 82%. The just culture perception of 212 staff nurses is presented through a dimension-level mean scores of each group based on the second-victim exposure (non-victims, second victims with support, and second victims without support).
Results
Results revealed that the second victim with the support group got the highest overall mean score (5.13 ± 0.13), while second victim with support and second-victim without support is (5.15 ± 0.10) and is (5.45 ± 0.11), respectively. ANOVA and Tukey HSD multiple comparisons test showed a significant difference in just culture mean scores between second victims with support and non-victims are significantly different at a 5% level of significance (p-value = 0.0386 < 0.005).
Conclusion
A better perceptual score of just culture was linked to perceived institutional support for second victims.
Clinical Evaluation of Anti-inflammatory and Analgesic Activities of AQUA-TURM (branded extract of Curcuma longa) in Individuals Suffering from Osteoarthritis of Knee(s): A Randomized, Double Blind, Placebo Controlled clinical study
Authors: Pande Shishir , Godatwar Pawankumar , Agiwal Sachin , Khatau Kiran , Tamoli Sanjay 
Published: February 2023

Abstract
Background: Anti-inflammatory and analgesic activities of Curcuma longa extract can be helpful in the management of Osteoarthritis.
Objectives: to evaluate the anti-inflammatory and analgesic activities of AQUATURM® (branded extract of Curcuma longa) in individuals suffering from Osteoarthritis of Knee joint
Methods: In present randomized, double blind, placebo controlled clinical study, a total 60 participants suffering from Osteoarthritis of the knee joint were randomized in two groups through a double-blinded procedure. AQUA-TURM® or its matching placebo was given in a dose of 1 capsule of 250 mg twice daily after meals for 90 days. Of these, 56 subjects completed the study (26 in AQUA-TURM® group and 30 in placebo group). Assessment of comparative change in knee joint pain on VAS, WOMAC Index was done on monthly intervals. Other parameters like time to walk 50 feet, requirement of painkillers, changes in the CRP levels and safety assessment through adverse event monitoring and laboratory parameters was done.
Results:
A significant reduction (p < 0.05) in pain was observed on VAS scale with the use of AQUA-TURM® as compared to placebo over a period of 90 days. On the WOMAC index, significant reduction (p < 0.05) was observed on the domains of pain and stiffness. A significant reduction was observed on CRP levels. AQUA-TURM® did not produce any significant adverse effects on clinical and laboratory parameters and was well tolerated.
Conclusion: Supplementation of AQUATURM® in individuals suffering from Osteoarthritis of Knee joint showed significant reduction in pain and swelling showing its analgesic and anti-inflammatory effect.
An Energy-Efficient Synchronization Scheme for Multi-hop WSNs through Passive Listening
Authors: Ayaluru SivaRama Krishna 
Published: February 2023

Abstract
Energy Conservation in Wireless Sensor Networks(WSNs) has emerged as challenging research in recenttimes. Considering the limited energy of batteries of sensor nodes, it is requiredto synchronize the nodes of a multi-hop WSN with as less energy as possible.Recently a hybrid synchronization scheme is proposed for practical WSNs,which is a combination of one way message dissemination and time-stamp freesynchronization. Passive listening can be employed additionally in the hybridapproach. In this work, we propose an energy efficient synchronizing scheme to synchronize every node of a multi-hop WSN. The proposed scheme, which minimizes energy consumption and lowers communication overhead, is a hybrid combination of passive listening based time-stamp free synchronization and one-way message dissemination. We derive MSE, CRLB of the estimates of clock skew and offset and observe that the proposed scheme is energy efficient in synchronizing n number of nodes of a multi-hop WSN compared to the existing scheme.
Modeling of Multilayer Perceptron Neural Network Hyperparameter Optimization and Training
Authors: Elansari Taoufyq , Ouanan Mohammed , Bourray Hamid 
Published: February 2023

Abstract
The multilayer perceptron (MLP) is an artificial neural network composed of one or more hidden layers. MLP has an extensive array of classification and regression applications in a wide range of domains. Selecting the right neural network architecture to solve a specific problem is one of the major areas of neural network research. The number of neurons in the hidden layers and the initial weights have a great effect on the convergence of MLP training algorithms. This paper presents a technique termed hyperparameter optimization model for the multilayer perceptron. We model in terms of mixed-variable optimization problems with nonlinear constraints. To solve the obtained model, a hybrid algorithm is used, based on the genetic algorithm and the backpropagation algorithm. The numerical results demonstrate the efficiency of the technique presented in this paper, and the advantages of the proposed model vis-a-vis the previous state-of-the-art model.
Targetable fibroblast phenotypes and EMT malignant cell states cooperate to promote tumor progression in esophageal adenocarcinoma
Authors: Walker Robert C. , Breininger Stella P. , Sharpe Benjamin P. , Harrington Jack , Reddin Ian , Tse Carmen , Rajak Rushda , Hayden Annette , Rahman Saqib , Grace Ben , Izadi Fereshteh , West Jonathan , Secrier Maria , Walters Zoë S. , Rose-Zerilli Matthew J.J. , Underwood Timothy J. 
Published: February 2023

Abstract
Background: Esophageal adenocarcinoma (EAC) is usually resistant to cytotoxic therapies and immunotherapies have gained little traction. Cancer-associated fibroblasts (CAF) are a major stromal cell population in the EAC tumor microenvironment associated with prognosis and treatment outcomes. Recent evidence suggests that cancer cell phenotypes related to EMT may determine CAF heterogeneity, but the molecular and cellular biology that underlies myofibroblast fate in EAC is not well understood.
Methods: To obtain the most comprehensive profile of CAF heterogeneity in EAC, we performed histopathologic, single-cell RNA sequencing and transcriptomic analyses on 28 samples from 26 patients and prognostic validation using two EAC cohorts from genomic consortia.
Results: Combining histologic and molecular profiles revealed five CAF phenotypes, including three myofibroblast phenotypes, associated with EMT-related signatures in EAC cells and cellular interactions that promote tumor progression and metastasis. We identified a specific myofibroblast subtype (CAF5) in close proximity to cancer cells and tumor vasculature with exclusive expression of TRPA1, offering a potential therapeutic vulnerability. We reconstructed CAF differentiation trajectories from esophagus-resident universal fibroblasts to identify candidate genes central to the CAF phenotype, and used this knowledge to construct a combined EMT-myofibroblast four gene signature (GSN, ATF1, ZEB2 and POSTN) that was highly prognostic in EAC and several other solid tumors.
Conclusions: This study stratifies EAC patients into two prognostic groups and reports important data supporting a cancer – CAF signalling axis, promoting myofibroblastic differentiation, that may inform more effective treatment strategies.
Entscheidend ist nicht die Aussage, sondern die Art und Weise der Protokollierung
Authors: Odermatt Luca , Ege Gian 
Published: February 2023

Einvernahmeprotokolle sind in Strafverfahren von erheblicher Bedeutung. Sie sind allerdings auch eine grosse Fehlerquelle. Trotzdem wurde im Rahmen der im Juni 2022 beschlossenen StPO-Revision darauf verzichtet, eine Aufzeichnungsverpflichtung für Einvernahmen im Vorverfahren einzuführen. Der vorliegende Aufsatz zeigt auf, welche Funktionen Einvernahmeprotokollen im Strafverfahren zukommt und welche Fehlerquellen bestehen. Vor diesem Hintergrund wird dargelegt, dass eine audiovisuelle Aufzeichnung der Einvernahmen verschiedene Probleme beheben würde und es daher sinnvoll wäre, eine entsprechende Aufzeichnungspflicht einzuführen.
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Les procès-verbaux des auditions constituent un élément essentiel en procédure pénale. Cependant, ils peuvent être à l'origine de nombreuses erreurs. Nonobstant ce fait, le législateur a renoncé, dans le cadre de la révision du CPP adoptée en juin 2022, à introduire une obligation d'enregistrement des interrogatoires durant la phase préliminaire de la procédure. Cet article présente les fonctions des procès-verbaux des auditions en procédure pénale ainsi que les sources d'erreurs potentielles. Dans ce contexte, il a été démontré que l'enregistrement audiovisuel des auditions permettrait de remédier à différents types de dysfonctionnements et qu'il serait judicieux d'introduire une obligation d'enregistrement en ce sens.
Multi-dimensional dynamic spatio-temporal evolution of the green development efficiency of water-energy-food in China
Authors: Li Jinqiu , Huang Dechun 
Published: February 2023

Abstract
This paper constructs a green development efficiency index framework of water-energy-food in China, and uses the Super-EBM model to measure it more accurately and scientifically. The existing studies on water-energy-food efficiency lack the analysis of regional differential decomposition and spatial state transition. In this paper, two kinds of models are used for complementary analysis. One is kernel density map, Dagum spatial Gini coefficient decomposition and traditional Markov chain, which does not contain spatial factors. The other is the global Moran index, spatial Markov chain and spatial spillover effect, including spatial factors. The spatio-temporal dynamic evolution of the green development efficiency of water-energy-food (GWEF) in China is compared from the perspective of national, regional and provincial dimensions. The conclusion is more scientific and comprehensive, which is conducive to the green collaborative development among water-energy-food, economy and environment in China. The study found that GWEF had a lot of room for improvement. The overall spatial difference was mainly derived from the regional difference. GWEF had a significant positive spatial autocorrelation. The development of GWEF maintained the convergence characteristics of clubs. The spatial spillover effect of the main influencing factors was studied.
Nano Emulsion Drug Delivery System: A Review
Authors: Mishra Nitin , Kaushik Niranjan , Sharma Pramod Kumar , Alam Md. Aftab 
Published: February 2023

Abstract:
In nanoemulsions, both oil and water droplets are stabilised by an amphiphilic surfactant. Ultrafine dispersions with varying drug loading, viscoelastic properties, and aesthetic characteristics may be useful for the administration of medication. A 20-500-nanometer droplet size range for nanoemulsions has been established. The biological behavior of a nanoemulsions formulation is heavily influenced by its droplet diameter and surface properties. Small droplet size results in clear emulsions; therefore, the appearance of the product is unaffected even by the addition of an oil phase. Nanoemulsions are oil-in-water dispersions that are transparent or translucent and are stabi-lized by an interfacial layer of surfactants and cosurfactant particles with droplet size smaller than 100 nm. New nanoscience-based technologies are becoming increasingly popular as a means of im-proving food safety, quality, and nutrition. In this field, nanoemulsions have been a key focus since they can be readily manufactured using current food components and technology. Food nanoemul-sions, which are tiny oil droplets distributed in water, are being used as delivery methods for a vari-ety of hydrophobic compounds, including nutrients, nutraceuticals, antioxidants, and antimicrobial agents. The present review is focused on the formulation, characterization, and applications of nanoemulsions.
Integrasi model pembelajaran dan pendekatan STEM (Science, technology, angineering and mathematic) terhadap hasil belajar
Authors: Irfandi Irfandi , Syahza Almasdi , Putra Zetra Hainul 
Published: February 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pendekatan STEM terintegrasi model pembelajaran terhadap hasil belajar peserta didik pada setiap jenjang pendidikan. Jenis penelitian ini adalah meta analisis. Meta analisis adalah penelitian yang dilakukan dengan cara merangkum, mengkaji, dan menganalisis data dari beberapa penelitian yang telah dilakukan. Sampel penelitian terdiri dari 30 artikel yang telah memiliki ISSN yang terdiri dari 20 artikel internasional dan 10 artikel nasional. Teknik analisis data yang digunakan dalam penelitian ini adalah dengan menghitung hasil penelitian dari setiap artikel. Berdasarkan hasil data yang dianalisis dapat disimpulkan bahwa integrasi pendekatan STEM model Problem Based Learning lebih efektif diterapkan dibandingkan model lainnya dengan rata-rata nilai 1,13 dengan kategori tinggi, integrasi pendekatan STEM terhadap hasil belajar lebih efektif diterapkan pada jenjang SMA dengan rata-rata nilai 0,67. Berdasarkan analisis Hasil Belajar STEM, Type Integrasi, Jenjang Pendidikan dan Tahun Publikasi menunjukan Penggunaan STEM integrasi model pembelajaran dapat dilakukan sebagai analisis pendahuluan dan dasar penelitian di bidang STEM. Hasil belajar STEM terintegrasi untuk membekali peserta didik dalam kesiapan bekerja dan keterampilan belajar abad ke-21.AbstractThis study aims to determine the effect of the STEM approach integrated learning model on student learning outcomes at every level of education. This type of research is meta-analysis. Meta-analysis is research conducted by summarizing, reviewing, and analyzing data from several studies that have been conducted. The research sample consisted of 30 articles, with an ISSN consisting of 20 international and ten national articles. The data analysis technique used in this research is to calculate the results of each article. Based on the results of the data analysis, integrating the STEM approach with the Problem-Based Learning (PBL) model is more effective than other models. PBL average score is 1.13 in the high category. The integration of the STEM approach to learning outcomes is more effectively applied at the high school level, with an average value of 0.67. The analysis of STEM, learning outcomes, type of integration, education level, and year of publication shows that integrated STEM learning models can be used as a preliminary analysis and basis for research in the STEM field. STEM learning outcomes are integrated to equip students with work readiness and 21st-century learning skills.
Pengaruh permainan LEGO dan media balok terhadap motorik halus
Authors: Sari Pruwita , Karta I Wayan , Nurhasanah Nurhasanah 
Published: February 2023

Penelitian ini bertujuan untuk menguji pengaruh secara parsial dan simultan permainan LEGO dan penggunaan media balok terhadap perkembangan motorik halus pada anak kelompok B TK Dharma Wanita Persatuan Gilik Desa Kawo. Penelitian ini menggunakan pendekatan eksperiment one group pretest -posttest. Subjek dalam penelitian ini adalah anak kelompok B TK Dharma Wanita Persatuan Gilik Desa Kawo yang berjumlah 15 orang anak. Pengumpulan data dalam penelitian dilakukan dengan medote observasi, dokumentasi serta menggunakan teknik analisis regresi linier berganda yakni uji normalitas, uji liniearitas, dan uji hipotesis. Hasil penelitian menunjukkan bahwa pada hipotesis 1 nilai thitung 12,191 t-tabel 2,179, maka Ha diterima yang berarti ada pengauh positif permainan lego terhadap perkembangan motorik halus. Kemudian hipotesis 2 nilai thitung 9,597 ttabel 2,179, maka Ha diterima yang berarti ada pengaruh positif penggunaan media balok terhadap perkembangan motorik halus. Hipotesis 3 nilai fhitung 115,304 ftabel 3,81 yang berarti H0 ditolak, sehingga dapat disimpulkan bahwa terdapat pengaruh positif dan signifikan permainan LEGO dan penggunaan media balok terhadap perkembangan motorik halus pada anak kelompok B TK Dharma Wanita Persatuan Gilik Desa Kawo. Implikasi dari penelitian ini diharapkan kepada tenaga pendidik untuk dapat menerapkan permainan LEGO dan penggunaan media balok dalam meningkatkan perkembangan motorik halus anak.AbstractThis study aims to examine the partial and simultaneous effect of LEGO games and the use of block media on fine motor development in group B children at the Dharma Wanita Unity Kindergarten, Gilik Village, Kawo. This study used a one-group pretest-posttest experimental approach. The subjects in this study were the children of Group B Kindergarten of the Dharma Wanita Association of Gilik, Kawo Village, which consisted of 15 children. Data collection in the study was carried out using observation methods, documentation, and multiple linear regression analysis techniques, namely the normality test, linearity test, and hypothesis testing. The results showed that in hypothesis 1, the tcount was 12.191 ttable 2.179, then Ha was accepted, which means lego games positively influence fine motor development. Then hypothesis 2 tcount 9.597 ttable 2.179, then Ha is accepted, which means there is a positive effect of using block media on fine motor development. Hypothesis 3: fcount 115.304 ftable 3.81, which means H0 is rejected, so it can be concluded that there is a positive and significant effect of LEGO games and the use of block media on fine motor development in group B children in Kindergarten Dharma Wanita Unity Gilik, Kawo Village. The implications of this research are expected for educators to be able to apply LEGO games and block media to improve children's fine motor development.
Patient Experiences With Virtual Care During the COVID-19 Pandemic: Phenomenological Focus Group Study
Authors: Curran Vernon R , Hollett Ann , Peddle Emily 
Published: February 2023

Background
Virtual care has expanded during the COVID-19 pandemic and enabled greater access and continuity of care for many patients. From a patient-oriented research perspective, understanding the patient experience with virtual care appointments is an important first step in identifying ways to better support patient use and satisfaction.

Objective
The purpose of this qualitative study was (1) to explore patients’ experiences and perspectives with the adoption and use of virtual care during COVID-19 in Newfoundland and Labrador, Canada, and (2) identify the education and informational needs of patients to inform future strategies for supporting patient use of virtual care.

Methods
Using a phenomenological approach, we conducted a focus group interview with a purposive sample of patient representatives representing a cross-section of the population of the province of Newfoundland and Labrador. Five patient representatives were recruited from the Newfoundland and Labrador Support Patient Advisory Council and participated in the focus group. The focus group was conducted in February 2022 via videoconferencing technology. Using thematic analysis, we identified several recurrent themes that described respondents’ experiences with the use of virtual care during COVID-19, as well as their perceptions of education and informational needs to support more effective patient use of virtual care.

Results
Respondents felt that virtual care is a beneficial addition to the health care system, enabling greater convenience and access to health care services. Key barriers and challenges in adopting and using virtual care appear to primarily arise from patients’ lack of knowledge, understanding, and familiarity with respect to virtual care. Cost, technological access, connectivity, and low digital literacy were challenges for some patients, particularly in rural communities and among older patient population. Patient education and support were critical and needed to be inclusive, easy to understand, and include information regarding privacy, security, consent, and the technology itself. The types of patient education experiences regarded as most helpful included peer support and knowledge sharing among patients themselves.

Conclusions
Beyond the COVID-19 pandemic, virtual care will have a continuing role in enhancing the continuity of care for patients through more convenient access. The education and informational needs of patients are important considerations in promoting the adoption and use of virtual care. Key education and informational needs and strategies were identified to enable and empower patients with the knowledge, digital literacy skills, and support to effectively use virtual care.
Rekonstruksi Subak Lestari Desa Anggabaya Sebagai Warisan Budaya Dunia dalam Mewujudkan Pencapaian Ketahanan Pangan
Authors: Yunita I Made , Sugiantiningsih Anak Agung Putu , Noor Muhammad , Misno I Made Gede Ray , Yasa I Gede Putu 
Published: February 2023

Subak adalah organisasi kemasyarakatan yang khusus mengatur sistem pengairan sawah (irigasi) yang digunakan dalam bercocok tanam padi. Subak memiliki pengaturan tersendiri, asosiasi-asosiasi yang demokratis dari petani dalam menetapkan penggunaan air irigasi untuk pertumbuhan padi. Penelitian ini bertujuan untuk menganalisis rekontruksi Subak Lestari sebagai warisan budaya dunia dalam mewujudkan pencapaian ketahanan pangan. Jenis penelitian ini menggunakan perspektif pendekatan kualitatif. Penelitian ini dilakukan secara purposive. Teknik pengumpulan data yang dilakukan adalah observasi, wawancara, dokumentasi, dan studi kepustakaan. Teknik analisis data menggunakan analisis kualitatif. Hasil penelitian menunjukkan subak bagi masyarakat tidak hanya sekedar sistem irigasi, tetapi juga merupakan konsep kehidupan bagi rakyat Bali itu sendiri. Dalam pandangan rakyat Bali, Subak adalah gambaran langsung dari filosofi Tri Hita Karana tersebut. Sebagai suatu metode penataan hidup bersama, Subak mampu bertahan selama lebih dari satu abad karena masyarakatnya taat kepada tradisi leluhur. Pembagian air dilakukan secara adil dan merata, segala masalah dibicarakan dan dipecahkan bersama, bahkan penetapan waktu menanam dan penentuan jenis padi yang ditanam pun dilakukan bersama. Harmonisasi kehidupan seperti inilah yang menjadi kunci utama lestarinya budaya Subak di pulau dewata. Rekonstruksi inilah yang perlu untuk dikembangkan. Penelitian ini dilakukan sebagai inventarisasi perda, pergub, dan dasar hukum termasuk awig-awig dalam penguatan subak sebagai kendali dalam peningkatan hasil pertanian yang berkualitas.