bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of various calcium antagonist on vasospastic angina: a systematic review
Authors: Singh Jaspal , Elton Andre , Kwa Melvin 
Published: January 2023

BackgroundCoronary artery vasospasm is an abnormal spasm of coronary arteries that cause transient or complete occlusion without exertion. It causes stable angina to ACS. However, this can be prevented by calcium channel blockers (CCBs) which suppress Ca2+influx into the vascular muscle cells. Nevertheless, several CCBs adverse effects are harmful for these patients. Selecting the right CCBs would give the best clinical practice.MethodThe studies were obtained from four major medical databases by various keywords. Inclusion and exclusion criteria were implemented as adult >18 years, observational study, English language and drug of interest. Duplicates were eliminated, and the remaining studies were reviewed. Final full-texts assessment was conducted independently by Newcastle-Ottawa Scale and Revised Cochrane.ResultsThe search found 1378 articles. However, six studies were selected after implementing the study criteria. Diltiazem was found to decrease angina and increase quality of life until 12th week of treatment; however, some adverse effects include atrioventricular block and recurrent angina up till 4th week were found. Meanwhile, nifedipine was found to decrease vasospastic angina (VSA) by the fourth and eighth weeks of treatment. Nevertheless, it caused excessive drop in BP and increase heart rate by eighth week. In addition, slow-release preparation of both CCBs were found to increase efficacy and compliance. Lastly amlodipine was also found to decrease VSA by 17%±140% and 33% after 6 weeks, but further studies needed.ConclusionDiltiazem, nifedipine and amlodipine are potent in decreasing VSA, however, tailoring specific CCBs adverse reactions to patient condition and the drug preparation would be substantially beneficial for the outcome.
Uveitis in psoriatic arthritis: study of 406 patients in a single university center and literature review
Authors: De Vicente Delmás Ana , Sanchez-Bilbao Lara , Calvo-Río Vanesa , Martínez-López David , Herrero-Morant Alba , Galíndez-Agirregoikoa Eva , Gonzalez-Mazon Iñigo , Barroso-García Nuria , Palmou-Fontana Natalia , Gonzalez-Gay Miguel A , Hernández José L , Blanco Ricardo 
Published: January 2023

Background/purposeThe manifestations of uveitis are well established in axial spondyloarthritis (ax-SpA), but not in psoriatic arthritis (PsA). We aimed to assess, in a large unselected series of PsA: (A) the frequency and clinical features of uveitis; (B) its association with PsA activity, the impact of disease and functional disability, and (C) its relationship with the biological treatment. In addition, a literature review was performed.MethodsRetrospective longitudinal study of PsA patients from a single referral hospital. PsA was classified according to the CASPAR criteria, and uveitis was diagnosed by experienced ophthalmologists.ResultsWe studied 406 patients with PsA (46.3±12.3 years). Uveitis was observed in 20 (4.9%). Uveitis was acute in all cases, anterior (80%), unilateral (80%) and recurrent (50%). Patients with uveitis had a higher prevalence of HLA-B27 (45% vs 7.5%, p<0.0001), sacroiliitis on MRI (25% vs 8.3% p=0.027), ocular surface pathology (10% vs 0.8%, p=0.021), and median PsA impact of Disease Score (5.9 (2.1–6.8) vs 1.25 (0.0–3.0), p=0.001) and Bath Ankylosing Spondylitis Functional Index (4 (1.6–5) vs 1.0 (0.0–3.5), p=0.01) than patients without uveitis.The exposure adjusted incidence rate (episodes/100 patients-year) of uveitis before versus after biological treatment decreased with anti-TNFα monoclonal antibodies (56.3 vs 9.4) and increased with etanercept (ETN) (6.03 vs 24.2) and secukinumab (SECU) (0 vs 50) (including only one patient treated in the last two cases).ConclusionThe prevalence of uveitis in patients with PsA was about 5%. The pattern was similar to that observed in ax-SpA. Uveitis was associated with a worse quality of life and greater functional disability. The uveitis exposure adjusted incidence rate decreased with anti-TNFα monoclonal antibodies and increased with ETN and SECU.
Escape panels in trawls: does placement matter when every individual contacting the panel can escape?
Authors: Melli Valentina , Herrmann Bent , Frandsen Rikke P. , Veiga-Malta Tiago , Feekings Jordan P. 
Published: January 2023

Escape panels are one of the bycatch reduction devices most used in trawl fisheries but their efficiency rely on fish actively contacting the panel to escape. To investigate if contact behaviour changes at different panel placements, we tested a 300 mm square mesh panel placed in the upper panel of the codend at 3, 4 and 7 m from the codline. Seven competing models of contact probability were fitted to the empirical data. Based on the results, we inferred that panel placement significantly affects escape efficiency due to a change in type of contact behaviour. Cod ( Gadus morhua) showed a contact increasing with length when the panel was closest to the codline, while contact probability decreased with length at the other placements. Similarly, contact probability for plaice ( Pleuronectes platessa) was found to increase with length at 3 and 4 m, whereas a length-independent contact best represented the data at 7 m. Finally, Nephrops ( Nephrops norvegicus) had in general low contact probability. The results provide new knowledge regarding species and placement-dependent panel escape.
Testing cover crop species under three soil moisture conditions in a controlled greenhouse environment
Authors: Ben Kalifa M.L. , VanVolkenburg H. , Vasseur L. 
Published: January 2023

Extreme climatic events, such as drought and heavy rainfall, are increasing with climate change. These events can threaten agroecosystems, including vineyards. Cover crops are often grown in vineyards for various reasons and can be an effective strategy for climate change adaptation. Understanding which cover crop species can establish well under extreme climate conditions is important. We conducted a greenhouse experiment to investigate the responses of nine cover crop species to overwatered and water-deficit conditions. Treatments included (1) overwatered soil condition, watered at 100% field capacity daily, (2) control, watered at 60%–70% every other day, and (3) water deficit, watered at 15%–20% weekly for 53 growing days. Results indicated that the total dry weight of all species decreased (most significantly) under water-deficit conditions. However, pubescent wheatgrass and red fescue did not exhibit any stress symptoms. Apart from alfalfa, all species established well under overwatered conditions despite slight yellowing of foliage for crimson clover and hairy vetch. Pearl millet and yellow sweet clover had the best establishment regardless of conditions. Our results provide important information on the selection of cover crops that can withstand climatic variability and thrive in the extreme conditions linked to the climate change scenario in Canada.
Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity
Authors: Zhang Xiaomin , Cheng Limin , Gao Chengqi , Chen Jing , Liao Shuangye , Zheng Yongqiang , Xu Liping , He Jingjing , Wang Danyang , Fang Ziqian , Zhang Jianeng , Yan Min , Luan Yi , Chen Siyu , Chen Likun , Xia Xiaojun , Deng Chunhao , Chen Guokai , Li Wende , Liu Zexian , Zhou Penghui 
Published: January 2023

AbstractSex is known to be an important factor in the incidence, progression, and outcome of cancer. A better understanding of the underlying mechanisms could help improve cancer prevention and treatment. Here, we demonstrated a crucial role of antitumor immunity in the sex differences in cancer. Consistent with observations in human cancers, male mice showed accelerated tumor progression compared with females, but these differences were not observed in immunodeficient mice. Androgen signaling suppressed T-cell immunity against cancer in males. Mechanistically, androgen-activated androgen receptor upregulated expression of USP18, which inhibited TAK1 phosphorylation and the subsequent activation of NF-κB in antitumor T cells. Reduction of testosterone synthesis by surgical castration or using the small-molecular inhibitor abiraterone significantly enhanced the antitumor activity of T cells in male mice and improved the efficacy of anti–PD-1 immunotherapy. Together, this study revealed a novel mechanism contributing to sex differences in cancer. These results indicate that inhibition of androgen signaling is a promising approach to improve the efficacy of immunotherapy in males.Significance:Androgen signaling induces immunosuppression in cancer by blocking T-cell activity through upregulation of USP18 and subsequent inhibition of NF-κB activity, providing a targetable axis to improve antitumor immunity in males.
Future Drying Subtropical East Asia in Winter: Mechanism and Observational Constraint
Authors: He Chao 
Published: January 2023

Abstract
Coupled climate models project robust wintertime wetting trend over midlatitude East Asia under global warming scenarios, but the projected change in precipitation shows large intermodel uncertainty over subtropical East Asia from southern China to southwestern Japan. Based on an ensemble of climate models participating in CMIP6, this study shows that the weakened southern branch westerly jet (SWJ) on the southern side of Tibetan Plateau (TP) plays a key role in suppressing subtropical East Asian precipitation. The SWJ is deflected into southwesterly wind on the southeastern side of TP, bringing ascent and precipitation to subtropical East Asia primarily through isentropic gliding. As a result of the poleward and upward shift of the planetary-scale westerly jet under global warming, the SWJ becomes weaker and it acts to suppress subtropical East Asian precipitation by weakening the southwesterly wind and ascent. The SWJ–precipitation linkage also exists on interannual time scales, but the sensitivity of precipitation to interannual SWJ variability is systematically underestimated by the models compared with observation. The combined effects of the change in SWJ strength and the sensitivity of precipitation to SWJ explain about 40% of the intermodel spread of the projected precipitation changes. Observational constraint on the SWJ–precipitation relationship amplifies the projected drying trend and narrows the intermodel spread. It shows that the regional-averaged precipitation over subtropical East Asia decreases by 3.3% per degree of warming, and the amplitude of precipitation reduction over subtropical East Asia (southern China) is about 1.4 (3.4) times the raw projection.
Simultaneous Assimilation of Planetary Boundary Layer Observations from Radar and All-Sky Satellite Observations to Improve Forecasts of Convection Initiation
Authors: Eure Keenan C. , Mykolajtchuk Paul D. , Zhang Yunji , Stensrud David J. , Zhang Fuqing , Greybush Steven J. , Kumjian Matthew R. 
Published: January 2023

Abstract
Accurate predictions of the location and timing of convection initiation (CI) remain a challenge, even in high-resolution convection allowing models (CAMs). Many of the processes necessary for daytime CI are rooted in the planetary boundary layer (PBL), which numerical models struggle to accurately predict. To improve ensemble forecasts of the PBL and subsequent CI forecasts in CAM ensembles, we explore the use of underused data from both the GOES-16 satellite and the national network of WSR-88D radars. The GOES-16 satellite provides observations of brightness temperature (BT) to better analyze cloud structures, while the WSR-88D radars provide PBL height estimates and clear-air radial wind velocity observations to better analyze PBL structures. The CAM uses the Advanced Research Weather Research and Forecasting (WRF-ARW) model at 3-km horizontal grid spacing. The ensemble consists of 40 members and observations are assimilated using the Gridpoint Statistical Interpolation (GSI) Ensemble Kalman Filter (EnKF) system. To evaluate the influence of each observation type on CI, conventional, WSR-88D, and GOES-16 observations are assimilated separately and jointly over a 4-h period and the resulting ensemble analyses and forecasts are compared with available observations for a CI event on 18 May 2018. Results show that the addition of the WSR-88D and GOES-16 observations improves the CI forecasts out several hours in terms of timing and location for this case.
Relevance of subclinical right ventricular dysfunction measured by feature-tracking cardiac magnetic resonance in non-ischemic dilated cardiomyopathy
Authors: Urmeneta Ulloa J. , Pozo Osinalde E. , Cabrera J. A. , Recio Rodríguez M. , Thuissard-Vasallo I. J. , Andreu-Vázquez C. , Islas F. , Pérez de Isla L. , Marcos-Alberca P. , Mahía P. , Cobos M. A. , Cabeza B. , Rodríguez-Hernández J. L. , Luaces Méndez M. , Gómez de Diego J. J. , Bustos A. , Pérez-Villacastín J. , de Agustín A. , Martínez de Vega V. 
Published: January 2023

Abstract
Background
Right ventricular (RV) dysfunction in patients with non-ischemic dilated cardiomyopathy (NICM) is associated with cardiovascular events. To analyze the feasibility of assessing RV myocardial deformation by feature tracking (FT)-cardiac magnetic resonance (CMR), and its usefulness as a prognostic marker.

Methods
Retrospective study of NICM patients undergoing CMR. Longitudinal FT-RV free wall (LFT-RVFW) and fractional area change (FAC) were obtained. Correlation with standard RV parameters was studied. An association with combined event (heart failure (HF), ICD implantation or cardiovascular death) was assessed using a logistic regression model.

Results
98 patients (64 ± 13 years) were included. Left ventricular (LV) systolic function (LVEF 29.5 ± 9.6%, 47% with LVEF ≥ 30%) and RV (RVEF 52.2 ± 14.6%, 72% with RVEF ≥ 45%). Follow-up of 38 ± 17 months, 26.5% presented at least one admission for HF. An excellent correlation of LFT-RVFW (r = 0.82) and FAC (r = 0.83) with RVEF was evident. No association of RV-FT parameters with prognosis entire study population was found. However, in patients with LVEF ≥ 30%, admissions for HF were associated with lower LFT-RVFW (−21.6 ± 6.6% vs −31.3 ± 10%; p = 0.006) and FAC (36.6 ± 9.6% vs 50.5 ± 13.4%; p < 0.001) values. Similar differences were observed when only patients with RVEF ≥ 45% were considered. An LFT-RVFW cut-off point of -19.5% and FAC of 36.5% showed good prognostic performance. Decreased LFT-RVFW or FAC represented an independent predictor of combined event in patients with LVEF ≥ 30%.

Conclusions
In NICM patients without severe LV dysfunction, decreased values of LFT-RVFW and/or FAC were associated with HF admissions, independently of RVEF.
COVID-19 vaccine attitudes among a majority black sample in the Southern US: public health implications from a qualitative study
Authors: Huang Wenting , Dove-Medows Emily , Shealey Jalissa , Sanchez Katia , Benson Lauren , Seymore DawnSheska D. , Sullivan Patrick S. , Bradley Heather M. , Siegler Aaron J. 
Published: January 2023

Abstract
Background
The COVID-19 pandemic continues to have high caseloads in the US, with vaccines a critical component of the response. Disparities in COVID-19 morbidity and mortality have been identified across states and racial/ethnic groups, which are likely in part due to disparities in COVID-19 vaccine uptake. This study aims to better understand and contextualize COVID-19 vaccine hesitancy among persons from under-represented racial/ethnic populations in the Southern US.

Methods
We conducted 29 in-depth interviews with a sample of households in Atlanta, GA that were selected from an address-based sampling frame. We purposively approached households, from February 6 to June 27, 2021, that declined participation in a national COVID-19 serosurvey to gain perspectives of people who are often under-represented in research. Interviews were conducted in-person or over phone calls for participants with that preference. Thematic analysis was used to identify barriers and facilitators of COVID-19 vaccination, and to contextualize drivers of vaccine hesitancy.

Results
Decision-making about vaccination was described as dynamic, and was compared to the feeling of being on a roller coaster. The predominant reported sources of information were mass media and social media. Facilitators of vaccination included altruism, positive communication from trusted community members and workplace colleagues, and local vaccine provision sites. Driving reasons for vaccine hesitancy included limited trust in the government and concerns about COVID-19 vaccine safety, which one participant compared to jumping off a cliff without a tested rope. Among a subset of participants, beliefs regarding perceived intent to harm the Black community were prevalent. Opportunities to optimally address vaccine hesitancy included countering negative social media messages with positive messaging that matches the community’s vivid ways of discussing vaccines, collaborating with community stakeholders on vaccine promotion efforts, and offering workplace-based vaccine promotion efforts.

Conclusions
This study presents data that indicate it may be optimal to more broadly define ‘community’ in COVID-19 vaccine promotion efforts to include social media and workplace venues. To optimize vaccine and vaccine booster uptake and equity, public health must address historic racism and other concerns by using outreach that is grounded in communities.
Development of a minimally invasive simultaneous estimation method for quantifying translocator protein binding with [18F]FEPPA positron emission tomography
Authors: Dassanayake Praveen , Anazodo Udunna C. , Liu Linshan , Narciso Lucas , Iacobelli Maryssa , Hicks Justin , Rusjan Pablo , Finger Elizabeth , St Lawrence Keith 
Published: January 2023

Abstract
Background
The purpose of this study was to assess the feasibility of using a minimally invasive simultaneous estimation method (SIME) to quantify the binding of the 18-kDa translocator protein tracer [18F]FEPPA. Arterial sampling was avoided by extracting an image-derived input function (IDIF) that was metabolite-corrected using venous blood samples. The possibility of reducing scan duration to 90 min from the recommended 2–3 h was investigated by assuming a uniform non-displaceable distribution volume (VND) to simplify the SIME fitting.

Results
SIME was applied to retrospective data from healthy volunteers and was comprised of both high-affinity binders (HABs) and mixed-affinity binders (MABs). Estimates of global VND and regional total distribution volume (VT) from SIME were not significantly different from values obtained using a two-tissue compartment model (2CTM). Regional VT estimates were greater for HABs compared to MABs for both the 2TCM and SIME, while the SIME estimates had lower inter-subject variability (41 ± 17% reduction). Binding potential (BPND) values calculated from regional VT and brain-wide VND estimates were also greater for HABs, and reducing the scan time from 120 to 90 min had no significant effect on BPND. The feasibility of using venous metabolite correction was evaluated in a large animal model involving a simultaneous collection of arterial and venous samples. Strong linear correlations were found between venous and arterial measurements of the blood-to-plasma ratio and the remaining [18F]FEPPA fraction. Lastly, estimates of BPND and the specific distribution volume (i.e., VS = VT − VND) from a separate group of healthy volunteers (90 min scan time, venous-scaled IDIFs) agreed with estimates from the retrospective data for both genotypes.

Conclusions
The results of this study demonstrate that accurate estimates of regional VT, BPND and VS can be obtained by applying SIME to [18F]FEPPA data. Furthermore, the application of SIME enabled the scan time to be reduced to 90 min, and the approach worked well with IDIFs that were scaled and metabolite-corrected using venous blood samples.
Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
Authors: Namai Fu , Sumiya Shunsuke , Nomura Natsumi , Sato Takashi , Shimosato Takeshi 
Published: January 2023

AbstractHere, we developed a genetically modified lactic acid bacteria (gmLAB) that produces green fluorescent protein (GFP)-conjugating, anti-programmed death-ligand 1 (PD-L1) single-chain variable fragments (scFv) for use as an anti-cancer device that targets immune checkpoint molecules. Since PD-L1 plays a key role as an immune checkpoint molecule in the tumor microenvironment, inhibition and detection of PD-L1 are important in cancer research. The anti-PD-L1 scFv was designed based on atezolizumab, a humanized IgG1 monoclonal antibody, and integrated into a lactococcal GFP gene expression vector. Gene expression from the constructed gmLAB was confirmed by western blotting and GFP fluorescence. The ability of GFP-conjugating anti-PD-L1 scFv against the target antigen, PD-L1 protein, was shown using an enzyme-linked immunosorbent assay. Finally, the ability to recognize PD-L1-expressing tumor-cell lines was confirmed using flow cytometry and fluorescence microscopy. Our results suggest that the gmLAB could be applied to in vivo imaging in cancer as an affordable diagnostic/treatment tool.
Graphical Abstract
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3
Authors: Hong Namgue , Kim Hee Jung , Kang Keunsoo , Park Ji On , Mun Seyoung , Kim Hyung-Gun , Kang Bong Hui , Chung Phil-Sang , Lee Min Young , Ahn Jin-Chul 
Published: January 2023

AbstractBackgroundTemporal lobe epilepsy (TLE) remains one of the most drug-resistant focal epilepsies. Glutamate excitotoxicity and neuroinflammation which leads to loss of synaptic proteins and neuronal death appear to represent a pathogen that characterizes the neurobiology of TLE. Photobiomodulation (PBM) is a rapidly growing therapy for the attenuation of neuronal degeneration harboring non-invasiveness benefits. However, the detailed effects of PBM on excitotoxicity or neuroinflammation remain unclear. We investigated whether tPBM exerts neuroprotective effects on hippocampal neurons in epilepsy mouse model by regulating synapse and synapse-related genes.MethodsIn an in vitro study, we performed imaging analysis and western blot in primary hippocampal neurons from embryonic (E17) rat pups. In an in vivo study, RNA sequencing was performed to identify the gene regulatory by PBM. Histological stain and immunohistochemistry analyses were used to assess synaptic connections, neuroinflammation and neuronal survival. Behavioral tests were used to evaluate the effects of PBM on cognitive functions.ResultsPBM was upregulated synaptic connections in an in vitro. In addition, it was confirmed that transcranial PBM reduced synaptic degeneration, neuronal apoptosis, and neuroinflammation in an in vivo. These effects of PBM were supported by RNA sequencing results showing the relation of PBM with gene regulatory networks of neuronal functions. Specifically, Nlgn3 showed increase after PBM and silencing the Nlgn3 reversed the positive effect of PBM in in vitro. Lastly, behavioral alterations including hypoactivity, anxiety and impaired memory were recovered along with the reduction of seizure score in PBM-treated mice.ConclusionsOur findings demonstrate that PBM attenuates epileptic excitotoxicity, neurodegeneration and cognitive decline induced by TLE through inhibition of the Nlgn3 gene decrease induced by excitotoxicity.Graphical Abstract