bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban Forestry and Urban Greening in Yenagoa, Bayelsa State, Nigeria: a Contribution to Climate Change Mitigation
Authors: Ezenwaka Jasper 
Published: September 2023

Abstract
This research was aimed at finding out the practices of urban forestry and urban greening in Yenagoa, Bayelsa State, Nigeria. Climate change issue has become a major topic of discussion among even the non-environmentalists because of its several effects on human and his environment. Types of plant species planted by homesteaders were appraised as well as reasons for the choices. Knowledge of climate change (causes, effects, and mitigations) were also appraised. Among the 30 participants that were involved in the Convenient sampling semi-structured survey, 43% had knowledge of climate change; 33% had knowledge of its causes; 40% were able to show some knowledge of role of vegetations in environmental purification, while all (100%) participants agreed that they would plant more vegetations if they had the knowledge of climate change and what role vegetations could play in curbing its effects. Various plant species were found around the homesteads including tree species, ornamental / horticultural, and agricultural species. The reasons for keeping the various species included economic, medicinal, and aesthetic values, in addition to others. More environmental education activities is recommended in order to increase people’s awareness to roles that greening of the environment can play in curbing the effects of climate change.
SHMT2 arginine methylation by PRMT1 facilitates esophageal cancer progression by enhancing glycolysis and one-carbon metabolism
Authors: Qiao Zhe , Li Yu , Cheng Yao , Liu Shiyuan , Li Shaomin 
Published: September 2023

Abstract

Background
Protein arginine methyltransferase 1 (PRMT1) is the main enzyme that directly responsible for the production of asymmetric dimethylarginine (ADMA), and upregulation of PRMT1 is observed in a variety of malignancies, including esophageal cancer (ESCA). Dysregulation of arginine methylation caused by PRMT1 overexpression is a driver of poor cancer progression, and the detailed mechanism of modulation is currently unknown.
Results
The present study confirmed a novel oncogenic mechanism of PRMT1 in ESCA. PRMT1 levels were significantly upregulated in ESCA, and its high expression correlated with TNM stage and poor patient prognosis. We continued to find the mechanisms by which PRMT1 expression was more relevant to ESCA progression. RNA-seq and KEGG enrichment analyses revealed that differentially expressed genes after PRMT1 silencing in ESCA might modulate serine/one-carbon metabolism. Knockdown of PRMT1 in vitro resulted in a significant reduction in ESCA cell growth, and indicators related to serine/one-carbon metabolism and glycolysis, whereas its overexpression showed opposite results. The catalytic activity of PRMT1 was crucial in mediating these biological processes. We found that PRMT1 mediated the ADMA modification of serine hydroxymethyltransferase 2 (SHMT2) at arginine 415 (R415), which activated SHMT2 activity and enhanced serine/one-carbon metabolism and glycolysis. The R415K mutation largely eliminated the arginine methylation of SHMT2 by PRMT1, and weakened PRMT1-induced glycolysis and serine/one-carbon metabolism.
Conclusion
Our study further confirmed the link between the two proteins, PRMT1 and SHMT2, as well as arginine methylation and glycolysis. The study of deeper molecular mechanisms will reveal a broader role of arginine methylation in the regulation of glycolysis.
Design and Fabrication of Multi-Material Pneumatic Soft Gripper Using Newly Developed High-Speed Multi-Material Vat Photopolymerization 3D Printer
Authors: Jiang Cho-Pei , Romario Yulius Shan , Bhat Chinmai , Hentihu M Fahrur Rozy , Zeng Xuan-Cheng , Ramezani Maziar 
Published: September 2023

Abstract
This study proposes a versatile, low-cost, shape-conforming soft gripper and fabricates it using the developed high-speed multi-material vat photopolymerization 3D printer for industrial applications. This additive manufacturing technology uses a rotary build plate that moves through 180° along the XY plane and multiple resin vats to accommodate different materials. A cleaning system uses pressurized air and alcohol to prevent contamination between layers and to increase the bond strength. The soft grippers are manufactured using soft (GC3D-ESK) and hard phase (AA-temp) materials to optimize the gripping force and prevent damage to the objects. Experimental results show that the tensile strength of the multi-material fabricated part (GC3D-HSK and AA-temp) is 5 times greater than that for the soft material GC3D-HSK. The multi-material specimen exhibits an elastic modulus of 89.28 MPa, which compares to only 2.08 MPa for the soft material. The multi-material fabricated specimen has high strength and high elastic modulus and is 65% more elongated than the hard material. In addition, the printing specimens that are cleaned with alcohol after successive printing of each layer have 4% greater tensile strength and 30% greater ductility. A shrinkage analysis determines the material compatibility. The percentage shrinkage for both GC3D-HSK and AA-temp is 0.1–0.2%. The printed pneumatic soft gripper is used to lift goods of less than 200g using a maximum pressure of 34.3 kPa. The printed gripper can lift objects of different weights and profiles without damaging the surface. The high-speed multi-material VP 3D printer can be used for additive manufacturing to optimize the design of pneumatic soft grippers.
The impact of skin involvement on the quality of life of breast cancer patients with chest wall recurrence and their caregivers
Authors: Zhou Danyang , Lin Qiulian , Cao Zhihui , Wu Wei , Nong Qiaohong , Hong Ruoxi , Wang Shusen 
Published: September 2023

Abstract
Purpose
To assess the impact of skin involvement on the quality of life (QoL) among breast cancer patients with chest wall recurrence and their caregivers.
Methods
We invited the female breast cancer patients with chest wall recurrence who received treatment at Sun Yat-sen University Cancer Center from November 2020 to July 2021 to complete EORTC QLQ-C30, EORTC QLQ-BR23, and HADS questionnaire. Their stable caregiver filled out SF-36 and HADS questionnaires. The assessment of the QoL was conducted once every two cycles of systemic treatment, with a total of three assessments. Survival analysis was performed using the Kaplan-Meier curves.
Results
A total of 42 participants and their family caregivers completed the QoL questionnaire for all three assessments. We found that in the skin involvement group, the breast symptoms worsened and the future perspectives decreased. The multiple functions and general health status of the patients in this group were also lower than those in the group without skin involvement. Skin involvement predicted the shorter disease progression of patients with chest wall recurrence. Compared to patients without skin involvement (5%), patients with skin involvement (29%) were more likely to experience the deterioration of arm symptoms. There were no differences in the family caregivers’ questionnaire between the two groups.
Conclusion
Chest wall recurrence patients with skin involvement had shorter disease progression intervals, more sever breast symptoms, and lower future prospects. This research further provided a reference for the application and promotion of QoL assessment tools in the management of recurrent breast cancer.
Psychometric evaluation of the Chinese Version of the Stimulant Relapse Risk Scale (C-SRRS) in Patients with Methamphetamine Use Disorder
Authors: Lin Jing-Shu , Ogai Yasukazu , Lin Chun , Chang Hu-Ming , Wu Yi-Chia , Huang Ming-Chyi , Fang Su-Chen 
Published: September 2023

Abstract
Background
Evaluating the risk of relapse is a pivotal step in the treatment of individuals with methamphetamine use disorder (MUD). The 30-item Stimulant Relapse Risk Scale (SRRS) was originally developed in Japan to meet the demand. This study examined the reliability, validity, and factor structure of the Chinese version of the SRRS (C-SRRS) for patients with MUD.
Methods
247 patients with MUD self-rated the C-SRRS. Cronbach’s alpha coefficients and inter-item correlation analysis were used to assess the internal consistency reliability. Construct validity was determined through confirmatory factor analysis (CFA), and concurrent validity was examined using the visual analogue scale (VAS) for drug craving and the severity of dependence scale (SDS). We followed the participants for 1 year and assessed the predictive validity based on the correlation of C-SRRS scores with the relapse rate within 3, 6, and 12 months of follow-up.
Results
CFA revealed satisfactory model fit estimates for 22 items of CRRS that consisted of four subscales. The four-factored 22-item C-SRRS had adequate internal consistency with Cronbach’s alphas ranging from 0.76 to 0.92. The 22-item C-SRRS scores were significantly correlated with the VAS and SDS scores as well as the relapse rate within 3, 6, and 12 months, indicating good concurrent and predictive validity of this scale. The receiver operating characteristic curve revealed a cutoff score of 40 could discriminate between high and low severity of methamphetamine dependence (area under the curve = 0.71, p < 0.01).
Conclusions
The 22-item C-SRRS that consists of four subscales is a valid and reliable instrument to assess the relapse risk in patients with MUD.
Framework for Personalized Prediction of Treatment Response in Relapsing-Remitting Multiple Sclerosis: A Replication Study in Independent Data
Authors: Sakr Anna Maria , Mansmann Ulrich , Havla Joachim , Ön Begum Irmak 
Published: September 2023

Abstract

Background
Individualizing and optimizing treatment of relapsing-remitting multiple sclerosis patients is a challenging problem, which would benefit from a clinically valid decision support. Stühler et al. presented black box models for this aim which were developed and internally evaluated in a German registry but lacked external validation.
Methods
In patients from the French OFSEP registry, we independently built and validated models predicting being free of relapse and free of confirmed disability progression (CDP), following the methodological roadmap and predictors reported by Stühler. Hierarchical Bayesian models were fit to predict the outcomes under 6 disease-modifying treatments given the individual disease course up to the moment of treatment change. Data was temporally split on 2017, and models were developed in patients treated earlier (n = 5517). Calibration curves, discrimination, and mean squared error (MSE) were assessed by external validation of models in more-recent patients (n = 3768). Standard count models were also applied and compared to the Bayesian ones.
Results
The performance of our temporally-validated relapse model (MSE: 0.326, C-Index: 0.639) is potentially superior to that of Stühler’s (MSE: 0.784, C-index: 0.608). Calibration plots revealed miscalibration. Our CDP model (MSE: 0.072, C-Index: 0.777) was also better than its counterpart (MSE: 0.131, C-index: 0.554). Results from standard count models were similar to the Bayesian ones.
Conclusions
The CDP model rebuilt and externally validated in independent data compared and strengthened the credibility of the Stühler models. Their model-building strategy was replicable.
Feasibility of Laparoscopic Surgery in Patients with Postoperative Adhesive Small Bowel Obstruction
Authors: Ochiai Hiroki , Ishii Yoshiyuki , Sako Hiroyuki , Yabe Nobushige , Watanabe Masahiko 
Published: September 2023

Abstract
Purpose Laparoscopic surgery for abdominopelvic disease is minimally invasive and associated with mild adhesion formation, resulting in a low incidence of small bowel obstruction after surgery. Theoretically, laparoscopic surgery may be a reasonable treatment modality for postoperative small bowel obstruction. This study aimed to evaluate the safety and effectiveness of laparoscopic surgery in the treatment of postoperative adhesive small bowel obstruction.
MethodsThis study included in 404 consecutive patients who underwent laparoscopic surgery for postoperative small bowel obstruction at Kitasato University Kitasato Institute Hospital, Tokyo, Japan, between 2012 and 2021.
ResultsThe median number of episodes of postoperative small bowel obstruction was 4 (range:1-26) times. The median duration of recurrent episodes of small bowel obstruction (hereinafter, duration of suffering) was 4 years (range:1-60). A transnasal decompression tube and ureteral stent were inserted before surgery in 34 (8.4%) and 14 (3.5%) patients, respectively. The median operation time and blood loss volume were 176 min (range:43-654) and 10 g (range:10-2335), respectively. Conversion to open surgery was required in 19 (4.5%) patients.
The following surgical procedures were performed: laparoscopic adhesiolysis (n=341; 84.4%), laparoscopic adhesiolysis with partial resection of the small bowel (n=56; 13.9%), and stricture plasty and/or bypass (n=7; 1.7%).
Postoperative complications occurred in 67 (16.8%) patients: paralytic ileus in 53 (13.1%) patients, small bowel injury in wight (1.9%) and postoperative bleeding in two (0.5%) patients. Operative mortality occurred in 1 (0.2%).
ConclusionsLaparoscopic surgery can be safely performed in patients with postoperative adhesive small bowel obstruction.
Full-Components Utilization of Cellulose Nanofibrils and Artificial Stone Wastes for Cement Enhancement
Authors: zhou bo , huang xin , yang xin , liu jize , huang zhuo , Yu Fei Fan , zhang xinxing 
Published: September 2023

Abstract
With the concept of carbon neutrality, the value-added utilization of biomass materials and solid wastes has become a cutting-edge topic. Cellulose nanofibrils (CNFs) have received much attention due to their excellent properties in terms of high aspect ratio, specific strength and specific surface area, but their large-scale preparation remains a great challenge. Here, we propose a facile aqueous solution method for the fabrication of CNFs through artificial stone wastes (ASWs)-assisted supramolecular interfacial interactions for the full-components utilization in cement mortar materials. The strong hydrogen bonding interaction between ASWs and CNFs can effectively prevent the intramolecular hydrogen bonding of CNFs and agglomeration of ASWs, while improving the stability of CNFs/ASWs suspensions. The resulted CNFs/ASWs with active hydroxyl or carboxyl group can improve the flexural and compressive strength of cement (30.8% and 37.8% higher than that of pristine cement, respectively) by embedding into the defects of cement mortar and promoting the hydration process of cement. This work not only provides a new idea for the large-scale preparation of biomass nanomaterials, but also opens up the full-components value-added utilization of biomass and solid wastes in cement materials.
Whole-body modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease
Authors: Martinelli Filippo , Heinken Almut , Henning Ann-Kristin , Wörheide Maria A. , Hensen Tim , González Antonio , Arnold Matthias , Asthana Sanjay , Budde Kathrin , Engelman Corinne D. , Estaki Mehrbod , Grabe Hans-Jörgen , Heston Margo , Johnson Sterling , Kastenmüller Gabi , Martino Cameron , McDonald Daniel , Rey Federico , Kilimann Ingo , Peters Olive , Wang Xiao , Spruth Eike Jakob , Schneider Anja , Fliessbach Klaus , Wiltfang Jens , Hansen Niels , Glanz Wenzel , Buerger Katharina , Janowitz Daniel , Laske Christoph , Munk Matthias H. , Spottke Annika , Roy Nina , Nauck Matthias , Teipel Stefan , Knight Rob , Kaddurah-Daouk Rima , Bendlin Barbara B. , Hertel Johannes , Thiele Ines 
Published: September 2023

Abstract
In this study, we aimed to understand the potential role of the gut microbiome in the development of Alzheimer's disease (AD). We took a multi-faceted approach to investigate this relationship. Urine metabolomics were examined in individuals with AD and controls, revealing decreased formate and fumarate concentrations in AD. Additionally, we utilized whole-genome sequencing (WGS) data obtained from a separate group of individuals with AD and controls. This information allowed us to create and investigate host-microbiome personalized models. Notably, AD individuals displayed diminished formate microbial secretion in these models. Additionally, we identified specific reactions responsible for the production of formate in the host, and interestingly, these reactions were linked to genes that have correlations with AD. This study suggests formate as a possible early AD marker and highlights genetic and microbiome contributions to its production. The reduced formate secretion and its genetic associations point to a complex connection between gut microbiota and AD. This holistic understanding might pave the way for novel diagnostic and therapeutic avenues in AD management.
Synthetic seeds of Acmella oleracea (Asteraceae) from micropropagated plants in different concentrations of 6-benzylaminopurine
Authors: Junior Jorge Braga Ribeiro , Dias Gabrielen de Maria Gomes , Guimarães Marcelo de Almeida , Nazareno Lailla Sabrina Queiroz , DoVale Júlio César , Zanuncio José Cola 
Published: September 2023

Abstract
Acmella oleracea, a leafy vegetable native to the Amazon region, has potential for the cosmetic, pharmaceutical and gastronomic industries. Hot environments and or low relative humidity accelerate losses of vigor and quality, making unfeasible to storage seeds of this plant. This makes necessary to develop new propagation and conservation techniques for A. oleracea. The objective was to evaluate the biometric characteristics, describe the stomata and to verify the presence or absence of epicuticular wax on the abaxial leaf epidermis of A. oleracea plantlet obtained from the conversion of synthetic seeds (SS) in vitro. The nodal segments of micropropagated plantlets, at different concentrations of 6-benzylaminopurine (BAP) (0.000; 0.025; 0.050; 0.100 and 0.200 mg l-1), were sectioned into explants of approximately 0.3 cm, encapsulated in alginate matrix to produce SS, inoculated in test tubes with Murashige & Skoog culture medium and kept in a growth room at a temperature of 25 ± 2 ºC and a photoperiod of 16 hours. The percentage of SS conversion, number of leaves and shoots, height and root dry mass were higher in the treatments with BAP. Shoot dry mass was 54.5% higher on plants originated from SS obtained with 0.100 mg l-1 of BAP than in the control. Anomocytic and ellipsoid-shaped stomata were well defined and epicuticular wax deposition was not observed on the abaxial epidermis of A. oleracea plantlets leaves. The stomata of A. oleracea and the absence of epicuticular wax on the leaf epidermis of this plant were similar between treatments.
Weak evidence of density dependent population regulation using predictive ability of models
Authors: Gebreyohannes Demissew , Houlahan Jeff 
Published: September 2023

Abstract
The relative importance of density dependence regulation in natural population fluctuations has long been debated1-3. The concept of density dependence implies that current abundance is determined by historical abundance. We have developed four models – two density dependent and two density independent - to predict population size one year beyond the training set and used predictive performance on more than 16,000 populations from 14 datasets to compare the understanding captured by those models. For 4 of 14 datasets the density dependent models make better predictions (i.e., density dependent regulated) than either of the density independent models. However, neither of the density dependent models is statistically significantly superior to density independent models for any of the 14 datasets. We conclude that the evidence for widespread density dependent population regulation is weak.
Autoimmune Disorders Reported Following COVID-19 Vaccination: A Disproportionality Analysis Using the WHO VigiBase
Authors: Kim Seohyun , Bea Sungho , Choe Seung-Ah , Choi Nam-Kyong , Shin Ju-Young 
Published: September 2023

Abstract
Purpose: Owing to autoimmune disorders (AIDs) and coronavirus disease (COVID-19) vaccines sharing common biological mechanisms, identifying the risk of AIDs associated with COVID-19 vaccines remains a critical unmet need. We aimed to assess the potential safety signals for 16 AIDs and explore co-reported adverse events (AEs) and drugs using the global database of the World Health Organization, VigiBase.
Methods: We assessed the occurrence of 16 AIDs following COVID-19 vaccination through the Standardised MedDRA Queries group “Immune-mediated/Autoimmune Disorders” from MedDRA and performed a disproportionality analysis using reporting odds ratio (ROR) and information component (IC) with 95% confidence intervals (CIs).
Results: We identified 25,219 AIDs associated with COVID-19 vaccines in VigiBase and detected four autoimmune safety signals following COVID-19 vaccination, including ankylosing spondylitis or psoriatic arthritis (ROR 1.86; 95% CI 1.53-2.27), inflammatory bowel disease (ROR 1.77; 95% CI 1.60-1.96), polymyalgia rheumatica (ROR 1.42; 95% CI 1.30-1.55), and thyroiditis (ROR 1.40; 95% CI 1.30-1.50), with positive IC025 values. The top co-reported AEs were musculoskeletal disorders, and immunosuppressants were the most representative co-reported drugs. Although rare, four AIDs showed disproportionality in reporting.
Conclusion: In response to the need to understand AID following COVID-19 vaccination using WHO-UMC VigiBase, four AIDs were identified in this study. Thus, our study highlights the need for active safety surveillance to detect potential AIDs and monitor the safety of the COVID-19 vaccination.