bluuebunny/crossref_metadata_2025_split huggingface dataset:
A diagnostic model of autoimmune hepatitis in unknown liver injury based on noninvasive clinical data
Authors: Yang Haiyan , Huang Lingying , Xie Ying , Bai Mei , Lu Huili , Zhao Shiju , Gao Yueqiu , Hu Jianjun 
Published: March 2023

AbstractAll the diagnostic criteria of autoimmune hepatitis (AIH) include histopathology. However, some patients may delay getting this examination due to concerns about the risks of liver biopsy. Therefore, we aimed to develop a predictive model of AIH diagnostic that does not require a liver biopsy. We collected demographic, blood, and liver histological data of unknown liver injury patients. First, we conducted a retrospective cohort study in two independent adult cohorts. In the training cohort (n = 127), we used logistic regression to develop a nomogram according to the Akaike information criterion. Second, we validated the model in a separate cohort (n = 125) using the receiver operating characteristic curve, decision curve analysis, and calibration plot to externally evaluate the performance of this model. We calculated the optimal cutoff value of diagnosis using Youden’s index and presented the sensitivity, specificity, and accuracy to evaluate the model in the validation cohort compared with the 2008 International Autoimmune Hepatitis Group simplified scoring system. In the training cohort, we developed a model to predict the risk of AIH using four risk factors—The percentage of gamma globulin, fibrinogen, age, and AIH-related autoantibodies. In the validation cohort, the areas under the curve for the validation cohort were 0.796. The calibration plot suggested that the model had an acceptable accuracy (p > 0.05). The decision curve analysis suggested that the model had great clinical utility if the value of probability was 0.45. Based on the cutoff value, the model had a sensitivity of 68.75%, a specificity of 76.62%, and an accuracy of 73.60% in the validation cohort. While we diagnosed the validated population by using the 2008 diagnostic criteria, the sensitivity of prediction results was 77.77%, the specificity was 89.61% and the accuracy was 83.20%. Our new model can predict AIH without a liver biopsy. It is an objective, simple and reliable method that can effectively be applied in the clinic.
Fluorouracil exacerbates alpha-crystallin B chain—mediated cell migration in triple-negative breast cancer cell lines
Authors: Yang Lili , Haga Yuya , Nishimura Akihide , Tsujii Yuki , Tanahashi Suzuno , Tsujino Hirofumi , Higashisaka Kazuma , Tsutsumi Yasuo 
Published: March 2023

AbstractAmong triple-negative breast cancer (TNBC) subtypes, the basal-like 2 (BL2) subtype shows the lowest survival rate and the highest risk of metastasis after treatment with chemotherapy. Research has shown that αB-crystallin (CRYAB) is more highly expressed in the basal-like subtypes than in the other subtypes and is associated with brain metastasis in TNBC patients. We therefore hypothesized that αB-crystallin is associated with increased cell motility in the BL2 subtype after treatment with chemotherapy. Here, we evaluated the effect of fluorouracil (5-FU), a typical chemotherapy for the treatment of TNBC, on cell motility by utilizing a cell line with high αB-crystallin expression (HCC1806). A wound healing assay revealed that 5-FU significantly increased cell motility in HCC1806 cells, but not in MDA-MB-231 cells, which have low αB-crystallin expression. Also, cell motility was not increased by 5-FU treatment in HCC1806 cells harboring stealth siRNA targeting CRYAB. In addition, the cell motility of MDA-MB-231 cells overexpressing αB-crystallin was significantly higher than that of MDA-MB-231 cells harboring a control vector. Thus, 5-FU increased cell motility in cell lines with high, but not low, αB-crystallin expression. These results suggest that 5-FU–induced cell migration is mediated by αB-crystallin in the BL2 subtype of TNBC.
Digital therapeutics from bench to bedside
Authors: Wang Changwon , Lee Chungkeun , Shin Hangsik 
Published: March 2023

AbstractAs a new therapeutic technique based on digital technology, the commercialization and clinical application of digital therapeutics (DTx) are increasing, and the demand for expansion to new clinical fields is remarkably high. However, the use of DTx as a general medical component is still ambiguous, and this ambiguity may be owing to a lack of consensus on a definition, in addition to insufficiencies in research and development, clinical trials, standardization of regulatory frameworks, and technological maturity. In this study, we conduct an in-depth investigation and analysis of definitions, clinical trials, commercial products, and the regulatory status related to DTx using published literature, ClinicalTrials.gov, and web pages of regulatory and private organizations in several countries. Subsequently, we suggest the necessity and considerations for international agreements on the definition and characteristics of DTx, focusing on the commercialization characteristics. In addition, we discuss the status and considerations of clinical research, key technology factors, and the direction of regulatory developments. In conclusion, for the successful settlement of DTx, real-world evidence-based validation should be strengthened by establishing a cooperative system between researchers, manufacturers, and governments, and there should be effective technologies and regulatory systems for overcoming engagement barriers of DTx.
Non-parametric galaxy morphology from stellar and nebular emission with the CALIFA sample
Authors: Nersesian Angelos , Zibetti Stefano , D’Eugenio Francesco , Baes Maarten 
Published: March 2023

Aims. We present a non-parametric morphology analysis of the stellar continuum and nebular emission lines for a sample of local galaxies. We explore the dependence of the various morphological parameters on wavelength and morphological type. Our goal is to quantify the difference in morphology between the stellar and nebular components.
Methods. We derived the non-parametric morphological indicators of 364 galaxies from the Calar Alto Legacy Integral Field Area (CALIFA) Survey. To calculate those indicators, we applied the StatMorph package on the high-quality integral field spectroscopic data cubes, as well as to the most prominent nebular emission-line maps, namely [O III]λ5007, Hα, and [N II]λ6583.
Results. We show that the physical size of galaxies, M20 index, and concentration have a strong gradient from blue to red optical wavelengths. We find that the light distribution of the nebular emission is less concentrated than the stellar continuum. A comparison between the non-parametric indicators and the galaxy physical properties revealed a very strong correlation of the concentration with the specific star formation rate and morphological type. Furthermore, we explore how the galaxy inclination affects our results. We find that edge-on galaxies show a more rapid change in physical size and concentration with increasing wavelength due to the increase in the optical free path.
Conclusions. We conclude that the apparent morphology of galaxies originates from the pure stellar distribution, but the morphology of the interstellar medium presents differences with respect to the morphology of the stellar component. Our analysis also highlights the importance of dust attenuation and galaxy inclination in the measurement of non-parametric morphological indicators, especially in the wavelength range 4000−5000 Å.
Recommendations of the AGG (Working Group for Obstetrics, Department of Maternal Diseases) on How to Treat Thyroid Function Disorders in Pregnancy
Authors: Hamza Amr , Schlembach Dietmar , Schild Ralf Lothar , Groten Tanja , Wölfle Joachim , Battefeld Wilgard , Kehl Sven , Schneider Michael O. 
Published: March 2023

Abstract
Objective These recommendations from the AGG (Committee for Obstetrics, Department of Maternal Diseases) on how to treat thyroid function disorder during pregnancy aim to improve the
diagnosis and management of thyroid anomalies during pregnancy.
Methods Based on the current literature, the task force members have developed the following recommendations and statements. These recommendations were adopted after a consensus by
the members of the working group.
Recommendations The following manuscript gives an insight into physiological and pathophysiological thyroid changes during pregnancy, recommendations for clinical and subclinical
hypo- and hyperthyroidism, as well as fetal and neonatal diagnostic and management strategies.
Das „Kataster für württembergische
Psychiatriepatienten“ und der Beginn der systematischen
Patientenerfassung in der Psychiatrie
Authors: Hofmann Christian , Reichelt Bernd , Müller Thomas 
Published: March 2023

ZusammenfassungDer Beitrag beschreibt die Bedeutung eines „Katasters“
für Psychiatriepatient:innen und den Beitrag seines Urhebers, des
jüdisch-protestantischen Arztes Wilhelm Weinberg in der psychiatrischen
Forschung des frühen 20. Jahrhunderts. Weinbergs Forschungen und dieses
Kataster gewannen vor dem Hintergrund der steigenden Relevanz der Humangenetik
in der Psychiatrie an Bedeutung. Der Beitrag zeigt, wie sehr der Psychiater und
Rassenhygieniker Ernst Rüdin durch Weinbergs statistische Methodik
profitieren konnte. In Württemberg wurde Weinberg zum Begründer
eines zentralen Patientenregisters. In der Zeit des Nationalsozialismus diente
dieses Register allerdings weniger der Forschung als vielmehr der sogenannten
erbbiologischen Bestandsaufnahme.
Das Pankreas – der „innere Alchemist“ in
Bedrängnis
Authors: Kracke Anita 
Published: March 2023

ZUSAMMENFASSUNGDas vielseitige Organ Pankreas wird durch die neuzeitlichen
Veränderungen der Lebens- und Haltungsbedingungen sowie
Umweltbelastungen überfordert. Da die Bauchspeicheldrüse
zwei unterschiedliche Funktionseinheiten in einem Organ
zusammenschließt, haben toxische Einflüsse, virale
Belastungen und Versorgungsmängel oft schwerwiegende Folgen.
Menschen und Tiere zeigen daher typische Zivilisationskrankheiten wie
Diabetes mellitus und schmerzhafte Entzündungen. Regulative
Therapien können das empfindliche Geschehen wieder normalisieren,
wobei eine artgerechte schonende Fütterung und Entgiftung neben der
Anwendung von Myco-Präparaten zu einer besonders tiefgreifenden
Entlastung führen. Ein Praxisfall demonstriert das.
Heilung mit Unkraut: Eichhornia crassipes bei exokriner
Pankreasinsuffizienz
Authors: Hentschel Brigitte 
Published: March 2023

ZusammenfassungDie dickstielige Wasserhyazinthe, Eichhornia crassipes, wird bei exokriner
Pankreasinsuffizienz eingesetzt, um die Bauchspeicheldrüse im Sinne einer
organotropen homöopathischen Therapie zu unterstützen. Das
„kleine“ homöopathische Mittel bewirkt eine Steigerung der
Sekretion von Verdauungssäften und Pankreasenzymen und hat eine dem Sekretin
und dem Cholecystokinin ähnliche Wirkung. Bei Pankreatitis ist die Anwendung
kontraindiziert.
The Value of Visfatin in the Prediction of Metabolic Syndrome: A Systematic Review and Meta-Analysis
Authors: Jiang Yingling , Zhou Lihua 
Published: March 2023

AbstractVarious studies have shown that visfatin may be connected to metabolic syndrome (MS). However, epidemiological studies yielded conflicting outcomes. The purpose of this article was to highlight the relationship between the plasma visfatin level and MS risk by conducting a meta-analysis of available literature. A comprehensive literature search of eligible studies was done up to January 2023. Data were presented as standard mean difference (SMD). Observational methodological meta-analysis was conducted to assess the relationships between visfatin levels and MS. The visfatin levels between patients with MS or not were calculated by SMD and 95% confidence interval (CI) using the random-effects model. Funnel plot (visually inspect publication bias), Egger’s linear regression test and Begger’s linear regression test were applied to describe the risk of publication bias. A sensitivity analysis was performed via sequentially omitting each of the study one by one. In total, 16 eligible studies comprising 1016 cases and 1414 healthy controls finally enrolled in the current meta-analysis for pooling meta-analysis. Overall, the meta-analysis results revealed that visfatin levels in MS patients were significantly greater than that of controls group (SMD: 0.60, 95% CI=0.18–1.03, I2=95%, p<0.001). The results of the subgroup analysis showed that gender did not affect the results of meta-analysis. This meta-analysis shed light on the fact that circulating visfatin levels were significantly higher in patients with MS than in the controls group. Visfatin may a chance to predict the occurrence of MS.
Presence of an Arterial Feeding Vessel on Cross-Sectional Imaging Predicts Treatment Response and Survival after Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma: A Retrospective Multivariable Analysis of 138 Patients
Authors: Guan Justin J. , Laroia Sandeep T. , McBride Aaron F. , Sun Shiliang , Huang Lihong , Yang Jingzhen , Dunlay Michael , Nagpal Prashant 
Published: March 2023

AbstractFinding a feeding vessel with diameter greater than 0.9 mm during transarterial chemoembolization (TACE) for hepatocellular cancer (HCC) has been shown to predict tumor necrosis on subsequent pathology. However, whether this translates into a useful clinical predictor for post-chemoembolization response and survival is unknown. This study aimed to determine whether the presence of an arterial feeder on pre-TACE cross-sectional imaging is associated with treatment response and survival after TACE for unresectable HCC. Retrospective medical record search for all chemo-embolizations performed for HCC from 2015 to 2016 yielded 138 patients who underwent 275 TACE sessions spanning 2011 to 2017. Patients consisted of 98 males (71%) with mean age of 62 (range, 37–86). Each patient underwent an average of two TACE sessions (range, 1–11). Endpoints included target tumor response and overall response defined by the mRECIST criteria, as well as patient survival. Preprocedural MRI/CT was reviewed for the presence of arterial feeder. Multivariable logistic regressions and Cox proportional hazard regressions were used to assess the effects of arterial feeder presence on treatment response and survival, respectively, adjusting for other covariates. Overall response was seen in 69% of patients. Arterial feeder was present on preprocedural cross-sectional imaging for 28% of TACE sessions. Median survival was 26.5 months (interquartile range, 13.2–38.1). The presence of arterial feeder led to better target tumor response (OR = 11.9, p < 0.0001), overall response (OR = 9.3, p < 0.0001), and improved survival (HR = 0.55, p = 0.02). The presence of an arterial feeder on pre-TACE cross-sectional imaging is associated with target tumor response, overall response, and survival after TACE.
Clinical Classification of Urethrocutaneous Fistulas Developing after Hypospadias Repair
Authors: Singh Abhinav , Singh Malika , Singh Raghubir 
Published: March 2023

Abstract
Background Clinical classification of the urethrocutaneous fistulas (UCFs) was designed to help the surgeons in (1) categorizing the fistulas, (2) selecting appropriate treatments, (3) keeping record at presentation and discharge, and (4) transferring information while referring a patient with recurrent fistula to a higher center.
Methods This retrospective study comprised of 68 patients with UCFs who reported in the “Hypospadias and VVFs Clinic” between 2004 and 2016. The study was performed to determine the incidence or etiology of the UCFs. It was rather performed to classify fistulas into different categories depending on the number of fistulas: A (5 fistulas), B (16 fistulas), C-a (28 fistulas), C-b (4 fistulas), D (4 fistulas), and E (11 fistulas). Category A fistulas healed conservatively. Category B fistulas underwent transection of the fistula tracts (tractotomy), purse-string closure, or multilayered closure (fistulorrhaphy). Category C-a fistulas were reenforced by preputial or penile skin flaps or waterproofing flaps. Category C-b fistulas underwent re-tubularization of their neourethral plates and eccentric closure of peno-preputial skin. The urethral plates of category D fistulas were re-tubularized after 3 to 6 months and cover was provided by the Cecil-Culp procedure. Category E fistulas had associated hairy urethra, stricture distal urethra, stricture with diverticulum, perifistular scar-induced chordee, long narrow urethral plate, balanitis xerotica obliterans (BXO), and short reconstructed neourethra. Accordingly, appropriate corrective measures were taken. Miscellaneous category F was excluded from the study.
Results Except for one in category D, none of the patients had any recurrence of fistula. One patient of category E had residual diverticulum.
Conclusion The designed clinical classification of UCFs is simple. Treatment was in accordance with reconstructive ladder wherein complexity of treatment paralleled with increasing complexity of fistulas.
Effectiveness of a Formal Business of Ophthalmology Course for Trainees
Authors: Siktberg Jonathan , de Castro-Abeger Alexander , Berkowitz Sean T. , Law Janice C. 
Published: March 2023

Abstract
Objective In medical school and residency training, there is little emphasis on the administrative and business aspects of running a clinical practice as either an employee or a business owner. However, by the first day of practice, young ophthalmologists need to have a basic understanding of the business of medicine to be successful in clinical practice and to avoid common pitfalls. Areas such as risk management, negotiation, financial health, lawsuits, marketing, coding, and professionalism are particularly important for practicing ophthalmologists to grasp. We instituted a formal practice management course to increase the early exposure of our trainees to the business aspects of ophthalmology.
Methods Ophthalmology trainees engaged in 11, 1-hour sessions over 3 weeks during a practice management course covering 10 of the most relevant business topics for early career ophthalmologists. A precourse needs assessment, and a postcourse satisfaction and outcomes survey were administered.
Results Of the 24 trainees who completed the presurvey, 96% of respondents had no previous training in contract negotiation, 88% lacked training in lawsuits, and 88% had no training in liability insurance. 96% had no inpatient coding education, and 88% had no outpatient coding training. Seventeen trainees completed the postsurvey, and statistically significant improvements in confidence ratings were found in all domains including coding, malpractice claims, and building a practice. 88% of trainees reported that the course improved their ability to code, and 100% agreed that the course improved their understanding of lawsuits, ability to negotiate a contract, and their understanding of the business of ophthalmology.
Conclusion A formal, targeted business of ophthalmology course improved the knowledge of trainees on essential business concepts. This course can serve as a model for other programs looking to meet this educational need.
Dynamic value sharing based on employee contribution as a competitiveness-enhancing device
Authors: Xie Zuomiao , Yuan Shiqi , Zhu Jinjing , Palferman Alistair 
Published: March 2023

AbstractAs the era of the knowledge economy has firmly established itself, the ability of firms to attract, motivate, and retain talents in order to realize stable and sustainable value creation, is increasingly critical. This paper proposes a dynamic value-sharing mechanism (DVS), based on human capital contribution, which combines the advantages of distribution fairness and dynamicity, to enhance firm value and profitability. As an instrument of analysis, this paper uses evolutionary game theory to study the feasibility of DVS and analyzes the impacts of key factors on the dynamic evolution game process and result. Evolutionary results show that: (1) DVS has the function of screening high-capability employees, and the high-capability employees ultimately dominate the value sharing under this mechanism; (2) DVS more stably promotes value creation, and the firm’s value increases to a greater extent than it would do without this mechanism and in the traditional static value sharing (SVS) model; (3) enterprises with a high proportion of talented employees have inherent advantages in implementing DVS, such as those involved in high-tech industries; and (4) the relationship between the ratio of overall profit sharing and the time of evolution to equilibrium is non-monotonic.
Inter-organizational conflict in the participatory web
Authors: Boéri Julie 
Published: March 2023

Abstract
Social, professional and political imaginaries are increasingly produced, contested and negotiated in and across online platforms. Adopting a socio-narrative perspective, this paper explores the ways in which collectivities of interpreters use communication technologies in the construction of, and competition over, their organizational identity, practice and space. It focuses on Babels, which organized activist interpreting in social forums, and AIIC, the international association of conference interpreters, and their use of babels.org and aiic.net. It analyzes the narrative ‘position’ of these collectivities through the prism of their Web 2.0 homepage design, and individual members’ enactment of, or departure from, these positions (narrative ‘locations’) in the context of an inter-website and interorganizational conflict. The study shows that the participatory web mediates and shapes how collectivities publicly project, enact and contest competing imaginaries of the profession, of the interpreting community, and of society at large.
Translation and the experience of exclusion
Authors: Pacheco Aguilar Raquel 
Published: March 2023

AbstractOn the basis of a critical approach to the concept of ‘social exclusion,’ this contribution explores the intersections between translation theory and social theory by offering a conceptual framework to study the impact of translation and interpreting in exclusion and inclusion processes. It examines the case of a migrants’ translation rights movement that took place in Lavapiés (Madrid, Spain) during the Covid-19 pandemic that sought to provide – and demand – medical interpreting in healthcare centers and other public areas. The article gives some insights into the complexities of the role of translation and interpreting as an inclusive practice in the context of a pandemic.
Ultrafast dynamics under high-pressure
Authors: Tu Hongyu , Pan Lingyun , Qi Hongjian , Zhang Shuhao , Li Fangfei , Sun Chenglin , Wang Xin , Cui Tian 
Published: March 2023

Abstract
High-pressure is a mechanical method to regulate the structure and internal interaction of materials. Therefore, observation of properties’ change can be realized in a relatively pure environment. Furthermore, high-pressure affects the delocalization of wavefunction among materials’ atoms and thus their dynamics process. Dynamics results are essential data for understanding the physical and chemical characteristics, which is valuable for materials application and development. Ultrafast spectroscopy is a powerful tool to investigate dynamics process and becoming a necessary characterization method for materials investigation. The combination of high-pressure with ultrafast spectroscopy in the nanocosecond∼femtosecond scale enables us to investigate the influence of the enhanced interaction between particles on the physical and chemical properties of materials, such as energy transfer, charge transfer, Auger recombination, etc. Base on this point of view, this review summarizes recent progress in the ultrafast dynamics under high-pressure for various materials, in which new phenomena and new mechanisms are observed. In this review, we describe in detail the principles of in situ high pressure ultrafast dynamics probing technology and its field of application. On this basis, the progress of the study of dynamic processes under high-pressure in different material systems is summarized. An outlook on in situ high-pressure ultrafast dynamics research is also provided.