bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of urbanization on construction material consumption: A global analysis
Authors: Schiller Georg , Roscher Julia 
Published: April 2023

AbstractUrbanization is considered a main driver of building material consumption. Nevertheless, statements on links between urbanization and resource consumption remain qualitative. This study aims to globally quantify the links between urbanization and non‐metallic mineral resource consumption at the level of nations. Based on hypotheses, we have investigated the relationship between construction material consumption and urbanization and further impact variables. Data were examined using descriptive and analytical statistical methods, by developing step‐by‐step regression models and representing them in a path diagram. The results show that urbanization alone does not adequately explain consumption of construction materials. Prosperity has a strong impact, too, but also does not have sufficient explanatory power in itself. Only the combination of both variables reveals their complex interrelationships. In principle, more prosperous societies consume more construction materials than less prosperous ones, regardless of the degree of urbanization. With low prosperity, however, material consumption per capita rises with increasing urbanization; with high prosperity, the effect is reversed. Developed societies are the problem today. However, with increasing urbanization and prosperity, dynamically growing societies will dramatically exacerbate the carrying capacity problem in the future. Then again, this is by no means inevitable. Rather, the key is to move from linear to consistently circular models of urbanization. These models must be comprehensive and spatially specified in order to develop sufficient clout in terms of effective resource protection through “circular urbanization.”
Male‐induced early puberty correlates with the maturation of arcuate nucleus kisspeptin neurons in does
Authors: Meunier Maxime A. , Porte Chantal , Poissenot Kévin , Vacher Hélène , Brachet Morgane , Chamero Pablo , Beltramo Massimiliano , Abecia José A. , Delgadillo José A. , Chemineau Philippe , Keller Matthieu 
Published: April 2023

AbstractIn goats, early exposure of spring‐born females to sexually active bucks induces an early puberty onset assessed by the first ovulation. This effect is found when females are continuously exposed well before the male breeding season starting in September. The first aim of this study was to evaluate whether a shortened exposure of females to males could also lead to early puberty. We assessed the onset of puberty in Alpine does isolated from bucks (ISOL), exposed to wethers (CAS), exposed to intact bucks from the end of June (INT1), or mid‐August (INT2). Intact bucks became sexually active in mid‐September. At the beginning of October, 100% of INT1 and 90% of INT2 exposed does ovulated, in contrast to the ISOL (0%) and CAS (20%) groups. This demonstrated that contact with males that become sexually active is the main factor prompting precocious puberty in females. Furthermore, a reduced male exposure during a short window before the breeding season is sufficient to induce this phenomenon. The second aim was to investigate the neuroendocrine changes induced by male exposure. We found a significant increase in kisspeptin immunoreactivity (fiber density and number of cell bodies) in the caudal part of the arcuate nucleus of INT1 and INT2 exposed females. Thus, our results suggest that sensory stimuli from sexually active bucks (e.g., chemosignals) may trigger an early maturation of the ARC kisspeptin neuronal network leading to gonadotropin‐releasing hormone secretion and first ovulation.
Solo self‐employment––Key policy challenges
Authors: Cieślik Jerzy , van Stel André 
Published: April 2023

AbstractThis study reviews key policy challenges relating to solo self‐employed workers––the segment with increasing shares in the workforce in most developed countries in recent decades. We document that this segment attracts the attention of policymakers within four policy domains: addressing decent work deficits, entrepreneurship and small business policies, activating marginalized groups through self‐employment, and improving the well‐being of the solo self‐employed. We offer an integrative framework enabling the analysis of synergies and contradictions of the various policy initiatives targeting the solo self‐employed. The study argues that workers who persistently employ only themselves should be understood as a (third) segment of the labor market qualitatively distinct from the traditionally defined categories of “employee” or “employer.” A policy‐oriented segmentation of the contemporary workforce using this “blurred trinary divide” is proposed with size estimates of its key segments and subsegments. Finally, the study discusses the prospects of the solo self‐employed in the emerging post‐pandemic economy and offers recommendations regarding future research and data collection.
Role of the systemic immune‐inflammation index in threatened abortion patients and predicting of abortion
Authors: Soysal Cenk , Sarı Hatice , Işıkalan Mehmet Murat , Özkaya Eren Berkay , Ulaş Özlem , Taşçı Yasemin , Keskin Nadi 
Published: April 2023

AbstractPurposeOur study aimed to compare the systemic immune inflammation index (SII), one of the hematological inflammation parameters, between pregnant women diagnosed with threatened abortion (TA) and healthy pregnant women, and to evaluate the prediction of abortion in pregnant women with TA.MethodsThis retrospective study compared 150 patients with TA group and 150 age‐ and gestational week‐matched healthy pregnant women (control group). Complete blood count parameters were assessed. SII, white blood cells (WBC), neutrophil to lymphocyte ratio (NLR), red cell distribution width (RDW), plateletcrit (PCT), platelet distribution width and monocyte to lymphocyte ratio (MLR) values were calculated. The SII value was calculated as follows: platelet count × (neutrophil/lymphocyte).ResultsSII, NLR, MLR, WBC, RDW, and PCT values were significantly higher in the TA group compared to the control group (923 ± 683 vs. 579 ± 364 [p < 0.001], 3.3 ± 2.0 vs. 2.1 ± 1.1 [p < 0.001], 0.3 ± 0.1 vs. 0.2 ± 0.2 [p < 0.001], 9.84 ± 2.87 vs. 8.6 ± 1.6 [p < 0.001], 13.9 ± 1.9 vs. 14.4 ± 2.3 [p = 0.032] and 0.3 ± 0.1 vs. 0.2 ± 0.0 [p < 0.001], respectively). Using receiver operating characteristics curve analysis to predict abortion in AI patients, the highest area under the curve was found for SII (0.727 for SII and 0.666 for NLR).ConclusionSII, NLR, MLR, RDW, and platelet to lymphocyte ratio (PLR) levels were significantly increased in patients with TA. This study supports the idea that several inflammatory pathways may play an important role in the pathogenesis of this disorder. SII may be a much better marker than NLR and PLR for predicting the inflammatory status of the disease and abortion in an ongoing pregnancy.
Clinical utility of fungal culture and antifungal susceptibility in cats and dogs with histoplasmosis
Authors: Hanzlicek Andrew S. , KuKanich Kate S. , Cook Audrey K. , Hodges Steven , Thomason John M. , DeSilva Rupika , Ramachandran Akhilesh , Durkin Michelle M. 
Published: April 2023

AbstractBackgroundCulture can be used for diagnosis and antifungal susceptibility testing in animals with fungal infections. Limited information is available regarding the diagnostic performance of culture and the susceptibility patterns ofHistoplasmaspp. isolates.Hypothesis/ObjectivesDescribe the clinical utility of culture and the susceptibility patterns ofHistoplasmaspp. isolates causing histoplasmosis in cats and dogs.AnimalsSeventy‐one client‐owned animals, including 33 cats and 19 dogs with proven or probable histoplasmosis.MethodsCulture was attempted from tissue or fluid samples. Diagnostic performance of culture, cytopathology, and antigen detection were compared with final diagnosis. Susceptibility to antifungal agents was determined for a subset (11 from dogs, 9 from cats) of culture isolates.ResultsCulture had a diagnostic sensitivity of 17/33 (52%; 95% confidence interval [CI], 34%‐69%) and 15/19 (79%; 95% CI, 61%‐97%) and specificity of 6/6 (100%; 95% CI, 54%‐100%) and 10/10 (100%; 95% CI, 69%‐100%) in cats and dogs, respectively. Culture was not positive in any animal in which cytopathology and antigen testing were negative. Target drug exposure (area under the concentration curve [AUC]/minimum inhibitory concentration [MIC] >25) should be easily achieved for all isolates for itraconazole, voriconazole, or posaconazole. Five of 20 (25%) isolates had fluconazole MIC ≥32 μg/mL and achieving target drug exposure is unlikely.Conclusions and Clinical ImportanceFungal culture did not improve diagnostic sensitivity when used with cytopathology and antigen detection. Susceptibility testing might help identify isolates for which fluconazole is less likely to be effective.
Steatotic hepatocellular carcinoma: Association of MRI findings to underlying liver disease and clinicopathological characteristics
Authors: Park Jae Hyon , Park Young Nyun , Kim Myeong‐Jin , Park Mi‐Suk , Choi Jin‐Young , Chung Yong Eun , Rhee Hyungjin 
Published: April 2023

AbstractBackground & AimsFatty change is commonly observed in hepatocellular carcinoma (HCC); however, the characteristics of steatotic and steatohepatitic HCCs are not well understood.MethodsThis retrospective study included patients with HCCs who underwent resection between January 2014 and December 2019 to evaluate clinicopathological and magnetic resonance imaging features. Tumours were categorized as magnetic resonance imaging‐steatotic, pathology‐steatotic and steatohepatitic HCCs and were defined as HCCs with ≥50% steatosis on in‐and‐oppose phase images, ≥34% tumour cells with lipid droplets and ≥50% tumour areas with steatohepatitic features on light microscopy respectively.ResultsOf 465 HCCs, 38 (8%), 23 (5%) and 15 (3%) were diagnosed as magnetic resonance imaging‐steatotic, pathology‐steatotic and steatohepatitic HCCs respectively. These HCC variants were less likely to be associated with hepatitis B virus infections than with type 2 diabetes mellitus, metabolic syndrome, non‐tumour liver steatosis and steatohepatitis. Moreover, microvascular invasion was less likely to be associated with them than either tumour size or differentiation. Type 2 diabetes and non‐tumour steatosis were independent risk factors for magnetic resonance imaging‐steatotic HCCs. Pathology‐steatotic HCCs and steatohepatitic HCCs were significantly associated with magnetic resonance imaging‐steatotic HCCs. A targetoid appearance in the transitional or hepatobiliary phase was also more prevalent in steatohepatitic‐HCCs than in non–steatohepatitic‐HCCs. When magnetic resonance imaging‐steatotic HCCs were combined with one or more ancillary features, the sensitivity and specificity were 60% and 97% respectively.ConclusionUnderlying fatty liver disease and metabolic syndrome are strongly associated with both steatotic and steatohepatitic HCCs. Clinicoradiological characteristics help identify steatohepatitic HCC with high specificity.
Partial identification for growth regimes: The case of Latin American countries
Authors: Carrillo‐Maldonado Paul 
Published: April 2023

AbstractThis study introduces the partial identification of the structural vector autoregressive model to estimate the effect of income distribution on output. For this purpose, this study follows the Post‐Keynesian growth models and identifies the demand regimes in Latin American countries for the period 1960–2014. The main results reveal that Bolivia, Colombia, Honduras, and Panama have profit‐led regimes. In addition, Costa Rica, Nicaragua, Peru, and Uruguay have wage‐led regimes. The regimes of Brazil, Chile, Ecuador, and Mexico could not be determined.
3D MRI PD‐SPACE‐COR Predicting Safety Margin for Coracoid Transfer
Authors: Ren Zhongkai , Huang Xiaohong , Peng Haining , Ma Jinlong , Zhang Yingze , Yu Tengbo 
Published: April 2023

ObjectiveThe maximum bone length available for coracoid process transfer varies among individuals, while no preoperative guideline has been developed for predicting the safety margin (SM) in Latarjet shoulder reconstruction. The aim of the study was to evaluate the 3D MRI proton density (PD)‐weighted sampling perfection with application‐optimized contrasts using different flip‐angle evolution (SPACE) sequence in preoperatively predicting SM for coracoid transfer.MethodsThe post‐multiplanar reconstructed images were obtained from 24 volunteers (17 males, seven females) to determine the clarity and sensitivity of the PD‐SPACE‐COR and PD‐SPACE‐FS‐COR protocols. Furthermore, the distance from the coracoid tip to the lateral edge of the attachment of trapezoid ligament (TL) was measured. To evaluate the accuracy of 3D MRI prediction, a cadaveric cohort has been launched in 32 shoulders (nine males, seven females). The distance between the tip of coracoid process and the outmost edge of TL footprint, namely, the SM, was measured.ResultsA better sensitivity was found in PD‐SPACE‐COR in detecting coracoclavicular ligaments (CCLs), including TL and conoid ligament (CL), compared to PD‐SPACE‐FS‐COR by ranking, McNemar test (P = 0.001), and kappa coefficients (κ = 0.51, P = 0.43). The SM determined by the PD‐SPACE‐COR protocol was 24.28 ± 2.17 mm while that by cadaveric morphometry was 25.53 ± 2.84 mm. No difference was found between measurements (P = 0.78).ConclusionThis research provides new insights for preoperatively geometrical planning coracoid transfer by 3D MRI PD‐SPACE‐COR, which motivates personalized medicine in orthopedics.
Diversity, equity, and inclusion in the melanoma research community
Authors: Portuallo Marie E. , Lu David Y. , Alicea Gretchen M. , Bolling Joel , Lee Rebecca , McQuade Jennifer , Warner Allison Betof , Davies Michael , Weeraratna Ashani , Villanueva Jessie , Rebecca Vito W. 
Published: April 2023

AbstractThe inaugural Diversity and Inclusion in Science Session was held during the 2021 Society for Melanoma Research (SMR) congress. The goal of the session was to discuss diversity, equity, and inclusion in the melanoma research community and strategies to promote the advancement of underrepresented melanoma researchers. An international survey was conducted to assess the diversity, equity, and inclusion (DEI) climate among researchers and clinicians within the Society for Melanoma Research (SMR). The findings suggest there are feelings and experiences of inequity, bias, and harassment within the melanoma community that correlate with one's gender, ethnic/racial group, and/or geographic location. Notably, significant reports of inequity in opportunity, discrimination, and sexual harassment demonstrate there is much work remaining to ensure all scientists in our community experience an academic workplace culture built on mutual respect, fair access, inclusion, and equitable opportunity.
Circadian variability of objective sleep measures predicts the relapse of a mood episode in bipolar disorder: findings from the APPLE cohort
Authors: Esaki Yuichi , Obayashi Kenji , Saeki Keigo , Fujita Kiyoshi , Iwata Nakao , Kitajima Tsuyoshi 
Published: April 2023

AimSleep disturbance, a core feature of bipolar disorder, is closely associated with mood symptoms. We examined the association between actigraphy sleep parameters and mood episode relapses in patients with bipolar disorder.MethodsThis prospective cohort study analyzed 193 outpatients with bipolar disorder who participated in the Association between the Pathology of Bipolar Disorder and Light Exposure in Daily Life (APPLE) cohort study. The participants' sleep was objectively evaluated via actigraphy over seven consecutive days for the baseline assessment and then at the 2‐year follow‐up appointment for mood episode relapses. The actigraphy sleep parameters were presented using the mean and variability (standard deviation) of each sleep parameter for 7 days.ResultsOf the 193 participants, 110 (57%) experienced mood episodes during follow‐up. The participants with higher variability in total sleep time had a significantly shorter mean estimated time to mood episode relapses than those with lower variability (12.5 vs. 16.8 months; P < 0.001). The Cox proportional hazards model, when adjusted for potential confounders, demonstrated that variability in total sleep time was significantly associated with an increase in the mood episode relapses (per hour; hazard ratio [HR], 1.407; 95% confidence interval (CI), 1.057–1.873), mainly in the depressive episodes (per hour; HR, 1.477; 95% CI, 1.088–2.006).ConclusionsOur findings suggest that consistency in sleep time might be useful, as an adjunct therapy, in preventing the recurrence or relapse of mood episodes in bipolar disorder.
Integrated transcriptome and proteome analysis provides new insights into camptothecin biosynthesis and regulation in Camptotheca acuminata
Authors: Zhang Huibo , Shen Xiaofeng , Sun Sijie , Li Ying , Wang Shu , Wei Jianhe , Guo Baolin , Sun Chao 
Published: April 2023

AbstractCamptotheca acuminata Decne., the main source of camptothecin (CPT), has received increasing attention for its remarkable antitumor activity. Many CPT derivatives are clinically used as effective anticancer agents worldwide. However, their biosynthesis mechanism remains unclear, and uncovering this pathway would greatly facilitate development of alternative CPT production methods to replace current inefficient plant‐derived ones. The expression of >30,000 genes was accurately quantified using unique molecular identifier RNA sequencing in 10 C. acuminata tissues, and 7854 proteins from five tissues were quantified with label‐free quantitative proteomics. Fifteen full‐length transcriptomes were sequenced with long‐read Oxford Nanopore Technologies, and 5692 alternative splicing events were discovered among 4746 genes. Integrated transcriptome and proteome analysis provided novel insights into CPT biosynthesis and its hierarchical regulation. Five cytochrome P450s and three O‐methyltransferases were considered as candidates involved in the biosynthesis of CPT and its derivatives, while 15 transcription factors potentially regulating CPT biosynthesis were screened. These findings provide important clues for elucidating the biosynthetic mechanisms of CPT and its derivatives and substantially contribute to the future production of these anticancer agents with synthetic biology. The generated large‐scale multiomics data also provide valuable resources for investigating the functional genomics of the most important CPT‐producing plant species–C. acuminata.
Does performance information receive political attention?
Authors: Hansen Jesper Asring 
Published: April 2023

AbstractThis study examines whether performance information affects the political agenda. I offer and test two hypotheses on performance information in politics—the attention‐allocation hypothesis, suggesting that politicians leverage performance data to devote attention to problems in service delivery, and the politicization hypothesis, stating that political concerns alter elected officials focus on performance information. I examine the hypotheses by gathering administrative data on pupils' standardized test scores combined with more than 6000 min of meetings in Danish municipal school committees, on which I leverage two‐way fixed effects models. The results show that performance shortfalls receive political attention, regardless of the politicization of the environment. In contrast to a vast literature stating how the political context alters attention to performance information, these results demonstrate that political entities leverage performance data to discover problems in need of attention in ways similar to those of other types of organizations.
The ambidextrous leadership‐innovative work behavior relationship in the public sector: The mediating role of psychological ownership
Authors: Kousina Elisavet , Voudouris Irini 
Published: April 2023

AbstractAmbidextrous leadership reflects a style that combines opening and closing behaviors, which can stimulate employees to engage in both exploration and exploitation. Drawing from tenets of ambidextrous theorization of leadership for innovation, this study examines whether the exhibition of ambidextrous leadership by public sector managers fosters public servants' innovative behavior and whether psychological ownership feelings with the unit mediates such effect. Utilizing multisource and multilevel data from 317 public servants across 109 working units, we find that ambidextrous leadership, —that is, the interaction of opening and closing behaviors—affects employees' innovative performance such that innovative work behavior is highest when both opening and closing behaviors are high. We also find that promotive‐oriented feelings of psychological ownership mediate such a relationship. In light of our findings, important implications for policy makers, public managers, and public sector's promotion procedures are discussed.
Electrochemical applications in RAS: A review
Authors: Ben‐Asher Raz , Gendel Youri , Lahav Ori 
Published: April 2023

AbstractElectrochemical water treatment for recirculating aquaculture systems (RAS) is a promising approach for replacing the biological water treatment methods and establishing a new RAS generation with improved cost‐effectiveness, lower environmental footprint, and no start‐up periods. On top of ammonia oxidation directly into N2(g), electrochemical oxidation results in effective disinfection, and in the removal of organic matter, including specific organic constituents such as off‐flavour agents. The paper provides an overview of incentives for the implementation of electrochemical methods in RAS. It covers the electrochemical principles relevant to aquaculture applications, the effects of physical and chemical parameters, as well as design considerations. In addition, the research performed to date for integrating electrochemical methods in RAS operation is reviewed and the variety of designs and operational configurations described. The electrochemical water treatment is perceived beneficial over biological water treatment especially in cold saline‐seawater aquaculture (e.g., Atlantic salmon), where large nitrification reactors are required and the large water consumption for purging processes can be curtailed. It is also beneficial for the culturing of nitrate‐sensitive species (e.g., L. vannamei). The paper points out the gaps to be overcome for allowing commercial breakthroughs based on electrochemical water treatment, including the need for expanding the practice and improving engineering practices by operating pilot systems for growing fish at both small and large scales; adjusting of electrochemical cell designs for reducing both capital and operational costs; developing full‐proof malfunction‐free dechlorination strategies, and evaluating and optimizing the disinfection abilities for inactivating typical pathogens in aquaculture.