bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does virtual reality technology reduce pain and anxiety during outpatient hysteroscopy? A randomised controlled trial
Authors: Sewell Thomas , Fung Yinka , Al‐Kufaishi Asmaa , Clifford Katy , Quinn Stephen 
Published: May 2023

AbstractObjectiveTo evaluate the effectiveness of virtual reality technology in reducing pain and anxiety during outpatient hysteroscopy.DesignA prospective randomised controlled trial.SettingA London University Teaching Hospital.PopulationWomen aged 18–70 years undergoing outpatient hysteroscopy procedures.MethodsAn unblinded randomised controlled trial was performed between March and October 2022 comparing standard outpatient hysteroscopy care with standard care with the addition of a virtual reality headset playing a virtual reality immersive scenario as a distraction technique.Main outcome measuresPain and anxiety numeric rating scores (NRS) from 0 to 11.ResultsEighty‐three participants were randomly allocated to the control (n = 42) and virtual reality groups (n = 41). The virtual reality group experienced significantly less anxiety during the procedure than the control group (mean NRS 3.29 versus 4.73, mean difference 1.50; 95% confidence interval [CI] 0.12–2.88; P = 0.03). There was no difference in reported average pain (mean NRS 3.73. versus 4.24, mean difference 0.51; 95% CI −1.76 to 0.64; p = 0.41) or maximum pain scores (mean NRS 5.32 versus 5.07, mean difference 0.25; 95% CI −1.05 to 1.55; P = 0.71).ConclusionsThe use of virtual reality technology as an adjunct to standard care can reduce patient‐reported anxiety but not pain during outpatient hysteroscopy procedures. Continued improvements in the technology and the development of increasingly immersive environments may continue to increase the potential to improve the patient experience in this setting.
Hemochromatosis as a secondary condition to systemic lupus erythematosus: A case report
Authors: Liu Jun , Zeng Jiashun , Li Peiting , Li Long , Gao Xueqin 
Published: May 2023

AbstractSystemic lupus erythematosus (SLE) is an autoimmune disorder that affects multiple organs and systems, including joints, the cardiovascular system, lungs, skin, kidneys, the nervous system, and blood. The clinical presentations of SLE are diverse and vary widely. In this report, we present a case of a patient whose SLE was complicated by hemochromatosis to enhance clinicians' comprehension of this infrequent or rare complication of SLE. We aim to provide insights into the diagnosis and treatment processes of this condition.
Letrozole‐induced inflammatory arthritis and tendinopathy in pediatric rheumatology setting
Authors: Baba Ozge , Kisaoglu Hakan , Kalyoncu Mukaddes 
Published: May 2023

AbstractMusculoskeletal symptoms associated with the use of aromatase inhibitors are a well‐known side effect of these drugs and are more prevalent in postmenopausal women. Aromatase inhibitor‐associated symptoms are not overt inflammatory processes so are described as arthralgia syndrome. In contrast, aromatase inhibitor‐associated inflammatory conditions such as myopathies, vasculitis, and rheumatoid arthritis were also reported. To our knowledge, inflammatory arthritis or tendinopathy associated with aromatase inhibitors were not reported in children despite their increased off‐label use in the pediatric setting. Herein, we report a girl with inflammatory arthritis and tendinopathy associated with letrozole treatment.
Potential for homoacetogenesis via the Wood–Ljungdahl pathway in Korarchaeia lineages from marine hydrothermal vents
Authors: Vulcano Francesca , Hribovšek Petra , Denny Emily Olesin , Steen Ida H. , Stokke Runar 
Published: May 2023

AbstractThe Wood–Ljungdahl pathway (WLP) is a key metabolic component of acetogenic bacteria where it acts as an electron sink. In Archaea, despite traditionally being linked to methanogenesis, the pathway has been found in several Thermoproteota and Asgardarchaeota lineages. In Bathyarchaeia and Lokiarchaeia, its presence has been linked to a homoacetogenic metabolism. Genomic evidence from marine hydrothermal genomes suggests that lineages of Korarchaeia could also encode the WLP. In this study, we reconstructed 50 Korarchaeia genomes from marine hydrothermal vents along the Arctic Mid‐Ocean Ridge, substantially expanding the Korarchaeia class with several taxonomically novel genomes. We identified a complete WLP in several deep‐branching lineages, showing that the presence of the WLP is conserved at the root of the Korarchaeia. No methyl‐CoM reductases were encoded by genomes with the WLP, indicating that the WLP is not linked to methanogenesis. By assessing the distribution of hydrogenases and membrane complexes for energy conservation, we show that the WLP is likely used as an electron sink in a fermentative homoacetogenic metabolism. Our study confirms previous hypotheses that the WLP has evolved independently from the methanogenic metabolism in Archaea, perhaps due to its propensity to be combined with heterotrophic fermentative metabolisms.
Efficiency of genetic modification in gene‐knockout sperm‐derived zygotes followed by electroporation of guide RNA targeting the same gene
Authors: Takebayashi Koki , Wittayarat Manita , Lin Qingyi , Torigoe Nanaka , Liu Bin , Hirata Maki , Nagahara Megumi , Tanihara Fuminori , Otoi Takeshige 
Published: May 2023

AbstractGenetic mosaicism is considered one of the main limitations of the electroporation method used to transfer CRISPR‐Cas9/guide RNA (gRNA) into porcine zygotes. We hypothesized that fertilization of oocytes with sperm from gene‐deficient boars, in combination with electroporation (EP) to target the same region of the gene in subsequent zygotes, would increase the gene modification efficiency. As myostatin (MSTN) and α1,3‐galactosyltransferase (GGTA1) have beneficial effects on agricultural production and xenotransplantation, respectively, we used these two genes to test our hypothesis. Spermatozoa from gene‐knockout boars were used for oocyte fertilization in combination with EP to transfer gRNAs targeting the same gene region to zygotes. No significant differences in the rates of cleavage and blastocyst formation as well as in the mutation rates of blastocysts were observed between the wild‐type and gene‐deficient spermatozoa groups, irrespective of the targeted gene. In conclusion, the combination of fertilization with gene‐deficient spermatozoa and gene editing of the same targeted gene region using EP had no beneficial effects on embryo genetic modification, indicating that EP alone is a sufficient tool for genome modification.
Understanding how educational maths apps can enhance learning: A content analysis and qualitative comparative analysis
Authors: Outhwaite Laura A. , Early Erin , Herodotou Christothea , Van Herwegen Jo 
Published: May 2023

AbstractEducational applications (apps) are ubiquitous within children's learning environments and emerging evidence has demonstrated their efficacy. However, it remains unclear what the active ingredients (ie, mechanisms), or combination of ingredients, of successful maths apps are. The current study developed a new, open‐access, three‐step framework for assessing the educational value of maths apps, comprised of type of app, mathematical content and app design features. When applied to a selection of available maths apps previously evaluated with children in the first 3 years of school (the final sample included 23 apps), results showed that practice‐based apps were the most common app type tested (n = 15). Basic number skills, such as number representation and relationships, were the most common area of mathematics targeted by apps (n = 21). A follow‐up qualitative comparative analysis showed observed learning outcomes with maths apps were enhanced when apps combined the following: a scaffolded and personalised learning journey (programmatic levelling) and explanations of why answers were right or wrong (explanatory feedback), as well as praise, such as ‘Great job!’ (motivational feedback). This novel evidence stresses the significance of feedback and levelling design features that teaching practitioners and other stakeholders should consider when deciding which apps to use with young children. Directions for future research are discussed.
Practitioner notesWhat is already known about this topic

Educational apps have been shown to support maths attainment in the first 3 years of school.
Several existing frameworks have attempted to assess the educational value of some of these maths apps.
Emerging experimental evidence also demonstrates the benefits of specific app design features, including feedback and levelling.
What this paper adds

Practice‐based maths apps are the most common type of app previously evaluated with young children.
These evaluated maths apps have mostly focused on basic number skills.
The combination of explanatory and motivational feedback, with programmatic levelling (either dynamic or static), was a necessary condition for enhancing learning outcomes with maths apps.
Implications for practice and policy

The inclusion of feedback and levelling in maths apps should be considered by app developers when designing apps, and by educational practitioners and parents when deciding which apps to use with their children.
Further consideration is also needed for the development of educational apps that include a broad range of maths skills.
Online Avatar Motion Adaptation to Morphologically‐similar Spaces
Authors: Choi Soojin , Hong Seokpyo , Cho Kyungmin , Kim Chaelin , Noh Junyong 
Published: May 2023

AbstractIn avatar‐mediated telepresence systems, a similar environment is assumed for involved spaces, so that the avatar in a remote space can imitate the user's motion with proper semantic intention performed in a local space. For example, touching on the desk by the user should be reproduced by the avatar in the remote space to correctly convey the intended meaning. It is unlikely, however, that the two involved physical spaces are exactly the same in terms of the size of the room or the locations of the placed objects. Therefore, a naive mapping of the user's joint motion to the avatar will not create the semantically correct motion of the avatar in relation to the remote environment. Existing studies have addressed the problem of retargeting human motions to an avatar for telepresence applications. Few studies, however, have focused on retargeting continuous full‐body motions such as locomotion and object interaction motions in a unified manner. In this paper, we propose a novel motion adaptation method that allows to generate the full‐body motions of a human‐like avatar on‐the‐fly in the remote space. The proposed method handles locomotion and object interaction motions as well as smooth transitions between them according to given user actions under the condition of a bijective environment mapping between morphologically‐similar spaces. Our experiments show the effectiveness of the proposed method in generating plausible and semantically correct full‐body motions of an avatar in room‐scale space.
Video frame interpolation for high dynamic range sequences captured with dual‐exposure sensors
Authors: Çoğalan U. , Bemana M. , Seidel HP. , Myszkowski K. 
Published: May 2023

AbstractVideo frame interpolation (VFI) enables many important applications such as slow motion playback and frame rate conversion. However, one major challenge in using VFI is accurately handling high dynamic range (HDR) scenes with complex motion. To this end, we explore the possible advantages of dual‐exposure sensors that readily provide sharp short and blurry long exposures that are spatially registered and whose ends are temporally aligned. This way, motion blur registers temporally continuous information on the scene motion that, combined with the sharp reference, enables more precise motion sampling within a single camera shot. We demonstrate that this facilitates a more complex motion reconstruction in the VFI task, as well as HDR frame reconstruction that so far has been considered only for the originally captured frames, not in‐between interpolated frames. We design a neural network trained in these tasks that clearly outperforms existing solutions. We also propose a metric for scene motion complexity that provides important insights into the performance of VFI methods at test time.
Physics‐Informed Neural Corrector for Deformation‐based Fluid Control
Authors: Tang Jingwei , Kim Byungsoo , Azevedo Vinicius C. , Solenthaler Barbara 
Published: May 2023

AbstractControlling fluid simulations is notoriously difficult due to its high computational cost and the fact that user control inputs can cause unphysical motion. We present an interactive method for deformation‐based fluid control. Our method aims at balancing the direct deformations of fluid fields and the preservation of physical characteristics. We train convolutional neural networks with physics‐inspired loss functions together with a differentiable fluid simulator, and provide an efficient workflow for flow manipulations at test time. We demonstrate diverse test cases to analyze our carefully designed objectives and show that they lead to physical and eventually visually appealing modifications on edited fluid data.
Robust Pointset Denoising of Piecewise‐Smooth Surfaces through Line Processes
Authors: Wei Jiayi , Chen Jiong , Rohmer Damien , Memari Pooran , Desbrun Mathieu 
Published: May 2023

AbstractDenoising is a common, yet critical operation in geometry processing aiming at recovering high‐fidelity models of piecewise‐smooth objects from noise‐corrupted pointsets. Despite a sizable literature on the topic, there is a dearth of approaches capable of processing very noisy and outlier‐ridden input pointsets for which no normal estimates and no assumptions on the underlying geometric features or noise type are provided. In this paper, we propose a new robust‐statistics approach to denoising pointsets based on line processes to offer robustness to noise and outliers while preserving sharp features possibly present in the data. While the use of robust statistics in denoising is hardly new, most approaches rely on prescribed filtering using data‐independent blending expressions based on the spatial and normal closeness of samples. Instead, our approach deduces a geometric denoising strategy through robust and regularized tangent plane fitting of the initial pointset, obtained numerically via alternating minimizations for efficiency and reliability. Key to our variational approach is the use of line processes to identify inliers vs. outliers, as well as the presence of sharp features. We demonstrate that our method can denoise sampled piecewise‐smooth surfaces for levels of noise and outliers at which previous works fall short.
What's in a Decade? Transforming Faces Through Time
Authors: Chen Eric Ming , Sun Jin , Khandelwal Apoorv , Lischinski Dani , Snavely Noah , Averbuch‐Elor Hadar 
Published: May 2023

AbstractHow can one visually characterize photographs of people over time? In this work, we describe theFaces Through Timedataset, which contains over a thousand portrait images per decade from the 1880s to the present day. Using our new dataset, we devise a framework for resynthesizing portrait images across time, imagining how a portrait taken during a particular decade might have looked like had it been taken in other decades. Our framework optimizes a family of per‐decade generators that reveal subtle changes that differentiate decades—such as different hairstyles or makeup—while maintaining the identity of the input portrait. Experiments show that our method can more effectively resynthesizing portraits across time compared to state‐of‐the‐art image‐to‐image translation methods, as well as attribute‐based and language‐guided portrait editing models. Our code and data will be available at facesthroughtime.github.io.
A Survey on Discrete Laplacians for General Polygonal Meshes
Authors: Bunge A. , Botsch M. 
Published: May 2023

AbstractThe Laplace Beltrami operator is one of the essential tools in geometric processing. It allows us to solve numerous partial differential equations on discrete surface meshes, which is a fundamental building block in many computer graphics applications. Discrete Laplacians are typically limited to standard elements like triangles or quadrilaterals, which severely constrains the tessellation of the mesh. But in recent years, several approaches were able to generalize the Laplace Beltrami and its closely related gradient and divergence operators to more general meshes. This allows artists and engineers to work with a wider range of elements which are sometimes required and beneficial in their field. This paper discusses the different constructions of these three ubiquitous differential operators on arbitrary polygons and analyzes their individual advantages and properties in common computer graphics applications.
We can work it out: A qualitative study of the work‐life experiences of people living with type 2 diabetes
Authors: Cleal Bryan , Nexø Mette Andersen , Willaing Ingrid 
Published: May 2023

AbstractAimsPeople with type 2 diabetes experience a range of negative work‐related outcomes at a time when people are expected to remain active within the labour market for longer. This study sought to identify the work‐related challenges faced by people with type 2 diabetes and ways to address them.MethodsRecruitment was undertaken in two contexts and focussed on people living with type 2 diabetes of working age (18–67). A further inclusion criterion for participants was that they were registered as having at least one diabetes‐related complication. Qualitative data was gathered via semi‐structured interviews and interactive workshops and analysed using systematic text condensation.ResultsThree themes were identified. The first theme highlighted that participants did not generally believe that their diabetes caused them any problems in the context of work, though this was not fully supported in their own accounts. The second theme pointed to the positive value attached to work, simultaneously indicating that work could negatively impact diabetes management and general health. The final theme highlighted the ways that both participants and their healthcare providers considered diabetes in isolation from other aspects of life, potentially delaying remedial actions.ConclusionsEpidemiological data indicate that there are serious issues linked to living with type 2 diabetes and work‐related outcomes. The extent to which these issues are recognized and understood may be obfuscated or contained by the value which people attach to work‐life. More needs to be done to tease out work‐related challenges for people with type 2 diabetes to better initiate timely remedial actions.
Sudden unexpected death in epilepsy during cenobamate clinical development
Authors: Rosenfeld William E. , Ferrari Louis , Kerr Wesley T. , Sperling Michael R. 
Published: May 2023

AbstractObjectiveWe assessed mortality, sudden unexpected death in epilepsy (SUDEP), and standardized mortality ratio (SMR) among adults treated with cenobamate during the cenobamate clinical development program.MethodsWe retrospectively analyzed deaths among all adults with uncontrolled focal (focal to bilateral tonic–clonic [FBTC], focal impaired awareness, focal aware) or primary generalized tonic–clonic (PGTC) seizures who received ≥1 dose of adjunctive cenobamate in completed and ongoing phase 2 and 3 clinical studies. In patients with focal seizures from completed studies, median baseline seizure frequencies ranged from 2.8 to 11 seizures per 28 days and median epilepsy duration ranged from 20 to 24 years. Total person‐years included all days that a patient received cenobamate during completed studies or up to June 1, 2022, for ongoing studies. All deaths were evaluated by two epileptologists. All‐cause mortality and SUDEP rates were expressed per 1000 person‐years.ResultsA total of 2132 patients (n = 2018 focal epilepsy; n = 114 idiopathic generalized epilepsy) were exposed to cenobamate for 5693 person‐years. Approximately 60% of patients with focal seizures and all patients in the PGTC study had tonic–clonic seizures. A total of 23 deaths occurred (all in patients with focal epilepsy), for an all‐cause mortality rate of 4.0 per 1000 person‐years. Five cases of definite or probable SUDEP were identified, for a rate of .88 per 1000 person‐years. Of the 23 overall deaths, 22 patients (96%) had FBTC seizures, and all 5 of the SUDEP patients had a history of FBTC seizures. The duration of exposure to cenobamate for patients with SUDEP ranged from 130 to 620 days. The SMR among cenobamate‐treated patients in completed studies (5515 person‐years of follow‐up) was 1.32 (95% confidence interval [CI] .84–2.0), which was not significantly different from the general population.SignificanceThese data suggest that effective long‐term medical treatment with cenobamate may reduce excess mortality associated with epilepsy.
Pan‐carpal arthrodesis as a treatment for distal radial fracture in a pony
Authors: Haddad Rabea , Kelmer Gal 
Published: May 2023

SummaryComplete, displaced radial fractures carry a poor prognosis in adult horses. In foals and ponies, fracture repair may have a good outcome following internal fixation. Distal radial fractures are difficult to stabilise due to limited bony purchase. Therefore, carpal arthrodesis may provide a viable option for salvaging the horse. In this report, we describe pan‐carpal arthrodesis as a treatment for distal radial fracture in an adult pony. A 12‐year‐old pony, 180 kg bodyweight, was presented due to left front non‐weight bearing lameness. Diagnosis of a closed, comminuted, displaced distal radial fracture, with antebrachiocarpal joint involvement, was made radiographically. The fracture was repaired and pan‐carpal arthrodesis was performed. Recovery was uneventful. The implants were gradually removed, in a minimally invasive standing procedure, due to surgical site infection. Two years following surgery, the horse is sound at a walk and trots freely with flexion of the affected carpus. Radiographs revealed healing of the fracture and failure of the arthrodesis. In essence, unintentionally, we performed temporary trans‐articular stabilisation by repairing a distal radial comminuted fracture, while preserving partial carpal range of motion. This technique, of temporary trans‐articular stabilisation, could be applied intentionally on other distal or proximal long bone fractures in horses.