bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and blood levels of daratumumab after switching from intravenous to subcutaneous administration in patients with multiple myeloma
Authors: Yamaoka Kenta , Irie Kei , Hiramoto Nobuhiro , Hirabatake Masaki , Ikesue Hiroaki , Hashida Tohru , Shimizu Tadashi , Ishikawa Takayuki , Muroi Nobuyuki 
Published: August 2023

Abstract
Purpose: The intravenous administration (IV) of daratumumab sometimes causes an infusion reaction and needs a long infusion time. Recently, a subcutaneous formulation (SC) of daratumumab, which has fewer infusion reactions and shorter administration time, was approved. However, because SC has a fixed dose, overdosing is a concern for patients with low body weights. In this study, we investigated the safety and blood levels of daratumumab after switching from IV to SC in patients with multiple myeloma (MM).
Methods: Patients who switched from IV to SC of daratumumab between June 2021 and May 2022 at Kobe City Medical Center General Hospital were included in the study. Blood daratumumab levels were measured using liquid chromatography-tandem mass spectrometry. Safety after switching from IV to SC was evaluated for six months and graded according to the Common Terminology Criteria for Adverse Events, version 5.0.
Results: The median body weight of ten patients included in the analysis was 57.4 kg (range: 45.0–74.4). Blood daratumumab levels were significantly increased after switching to SC (p=0.002); median through concentration at the last IV dose was 403.6 µg/mL (range: 96.3–776.3) and that at the third SC dose was 557.1 µg/mL (range: 288.3–997.2). Grade 1–2 injection site reactions were observed in six patients (60.0%) after switching to SC. A new grade 3 adverse event was observed in only one patient (neutropenia).
Conclusion:The blood levels of daratumumab were significantly increased after switching from IV to SC in patients with MM; however, the dosage was tolerable.
Comparison between Multi-Scale Decomposition and Spatial Frequency based Methods for the Integration of Panchromatic and Multispectral Pictures
Authors: Kumar Gaurav , Rajput Upendra Kumar , Saini Rakesh Kumar 
Published: August 2023

Abstract

A technique for merging a high-resolution PAN image with a low-resolution multispectral image from LISS-III and World View-2 is suggested in this paper. The spatial-frequency technique, in particular the pseudo-Wigner distribution (PWD), offers pixel-by-pixel analysis, shift invariance, and characterization of local spectral features of nonstationary images. The suggested approach is compared with multi-scale decomposition techniques like NSCT and SWT. Using root mean square error (RMSE), peak signal to noise ratio (PSNR), correlation coefficient (CC), relative dimensionless global error (ERGAS), and RASE, the performance of the suggested technique, the non-subsampled contour-let transform, and the stationary wavelet transform (SWT), is compared. Based on thorough tests using the LISS-III and World View-2 datasets, it is observed that the suggested method is statistically and visually more effective than traditional picture fusion algorithms. The suggested approach enhances spatial resolution while retaining spectral data.
Oceanic turbulent effect on the propagation properties of a Generalized Hermite cosh-Gaussian beam
Authors: Saad Faroq , Benzehoua Halima , Belafhal Abdelmajid 
Published: August 2023

Abstract
This paper aims to study the evolution behavior of Generalized Hermite cosh-Gaussian beam (GHCGB), when it propagates through a turbulent oceanic medium. Extended Huygens-Fresnel principal is used to evaluate the received intensity expression for the considered beam propagating in oceanic turbulence. Numerical examples are analyzed to illustrate the variations of average intensity under the influences of the oceanic turbulence parameters and the source beam parameters. Results show that the GHCGB propagating in stronger oceanic turbulence will lose its first profile and evolve into a Gaussian distribution rapidly with the larger dissipation rate of mean squared temperature and relative strength of temperature and salinity fluctuations or the smaller rate of dissipation of turbulent kinetic energy per unit mass of fluid, in the far field. According to the provided study, the results obtained are useful to the practical application of the GHCGB in oceanic turbulence for both imaging systems and underwater optical communication.
Xiaoyan granule plus aptinib in patients with advanced gastric cancer who failed radiotherapy and chemotherapy: A prospective, phase II trial
Authors: Kong Fanming , Wang Na , Li Longhui , Yu Minghui , Liang Yangyueying , Liao Dongying 
Published: August 2023

Abstract
Objective
Xiaoyan granule (XYG) is a type of Chinese medicine preparation, which has been confirmed as an adjuvant therapeutic scheme for the treatment of advanced gastric cancer (AGC). Apatinib has been recommended as a third-line treatment option for AGC. The purpose of this study was to evaluate the efficacy and safety of XYG combined with apatinib in the treatment of AGC patients who failed radiotherapy and chemotherapy.
Methods
207 eligible patients were enrolled at the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine in this randomized controlled trial from January 2020 to December 2021. They were assigned to the treatment group to receive XYG combined with apatinib (n = 100) or to the control group to accept apatinib (n = 107, among which 7 patients were lost to follow-up). Patients with stable status continued to be treated (28 days as a course of treatment) until disease progression or unaccepted toxicity occurred. The primary endpoint was progression-free survival (PFS). The secondary endpoints were objective response rate (ORR), disease control rate (DCR), and safety.
Results
In contrast to the control group, patients in the treatment group were able to significantly prolong PFS (6.67 vs 4.00 months, P < 0.05). The second endpoints of the treatment group were also remarkably improved (ORR: 46.0% vs 41.0%, P < 0.05; DCR: 82.0% vs 69.0%, P < 0.05). In terms of safety, there was no statistical difference in any grade of adverse events between the two groups. The treatment group could significantly reduce the incidence of grade III-IV adverse events.
Conclusion
The synergistic effect of XYG combined with apatinib could prolong the survival time and improve the safety of AGC patients who failed radiotherapy and chemotherapy.
A 10-gene signature associated with elevated levels of NCAPH identifies luminal A breast cancer patients with a risk of relapse
Authors: Mendiburu-Eliçabe Marina , García-Sancha Natalia , Corchado-Cobos Roberto , Martínez-López Angélica , Chang Hang , Mao Jian Hua , Blanco-Gómez Adrián , García-Casas Ana , Castellanos-Martín Andrés , Salvador Nélida , Jiménez-Navas Alejandro , Pérez-Baena Manuel Jesús , Sánchez-Martín Manuel Adolfo , Abad-Hernández María Del Mar , Carmen Sofía Del , Claros-Ampuero Juncal , Cruz-Hernández Juan Jesús , Rodríguez-Sánchez César Augusto , García-Cenador María Begoña , García-Criado Francisco Javier , Vicente Rodrigo Santamaría , Castillo-Lluva Sonia , Pérez-Losada Jesús 
Published: August 2023

Abstract
Background
Despite their generally favorable prognosis, luminal A tumors paradoxically pose the highest ten-year recurrence risk among breast cancers, with a quarter recurring within five years. Identifying such patients is crucial as long-term relapsers could benefit from extended hormone therapy, while early relapsers may require aggressive treatment. We propose a gene signature, sourced from genes such as NCAPH associated with luminal A breast cancer pathogenesis and poor prognosis, for improved stratification of these high-risk patients.
Methods
We used in vitro and in vivo mouse models to study the implication of NCAPH in breast cancer progression. We performed transcriptomic analysis from a backcross cohort of mice with breast tumors. Transcripts that were associated with high intratumoral Ncaph levels were used for a LASSO multivariate regression model in the human databases.
Results
We demonstrated that NCAPH participates in the pathogenesis of luminal breast cancer in vitro and in vivo using different mouse models. Transgenic mice overexpressing NCAPH generated breast tumors with a long latency, and in MMTV-NCAPHErbB2+ double-transgenic mice, the luminal tumors formed were more aggressive. In addition, high levels of Ncaph were associated with worse evolution and a poor response to chemotherapy in a cohort of genetically heterogeneous transgenic mice generated by backcrossing. Moreover, NCAPH levels were higher in patients with poor long-term evolution. Using LASSO multivariate regression, we identified a ten-gene risk score formed by a gene signature (Gene Signature for Luminal A 10 or GSLA10) that correlated with high intratumoral NCAPH expression and poor luminal A breast cancer evolution. This GSLA10 signature outperforms the Oncotype DX signature in distinguishing tumors with a poor outcome (previously categorized as luminal A by PAM50) in three independent human cohorts.
Conclusions
The GSLA10 signature assists in identifying patients with luminal A tumors exhibiting poor prognosis, who could thus potentially benefit from personalized treatment strategies.
Predictors of HIV status disclosure among PLHIV in the Volta region of Ghana: the disclosure conundrum and its policy implications.
Authors: Alhassan Robert Kaba 
Published: August 2023

Abstract

Background Globally, over 40 million lives have been claimed by HIV/AIDS. In Ghana, more than 350,000 people are currently living with HIV with 66% of them being females; out of this number, 71% know their status and 99% of the people diagnosed with HIV in Ghana received sustained antiretroviral therapy (ART), and 79% on ART have achieved viral suppression. Non-disclosure of HIV status is a major barrier to HIV/AIDS eradication; yet, little is known on the determinants of HIV status disclosure among the adult population of people living with HIV (PLHIV) in Ghana. Objective Determine the predictors of HIV status disclosure among the adult population of PLHIV and stimulate national policy discourse on support systems for self-disclosure in Ghana. Methods The study is a descriptive cross-sectional design among PLHIV (n = 181) in a tertiary hospital in the Volta region of Ghana. Bivariate analysis with Pearson Chi-square and Fisher’s Exact tests were run alongside stepwise forward logistic regression to determine factors associated with HIV status disclosure among PLHIV at 95% confidence level. Results HIV status disclosure was reported by 50% of the respondents; nearly 65% disclosed their status to non-family members. HIV status disclosure was significantly associated with marital status (p = 0.000), level of education (p = 0.035), divorce due to HIV (p = 0.000), monthly income (p = 0.019), occupation (p = 0.010) and partner being HIV positive. The odds of disclosing HIV status was higher among single/never married persons (OR = 0.012; p-value = 0.017, 95% [CI = 0.000 0.447), persons of Catholic denomination (OR = 0.060; p-value = 0.057, 95% [CI = 0.003 1.089), persons with monthly income of approximately (USD 44–88) (OR = 0.068; p-value = 0.011, 95% [CI = 0.009 0.543]) and persons adherent to ART (OR = 6.161; p-value = 0.058, 95% [CI = 0.937 40.490]). Conclusions HIV status disclosure is low in Ghana due to socio-economic and religious factors. There is the need for a national debate on policy guidelines for HIV status disclosure for PLHIV; targeted support systems for vulnerable groups within PLHIV would also help ameliorate their predicaments.
To waste or not to waste: A multi-proxy analysis of human-waste interaction and rural waste management in Indus Era Gujarat
Authors: Chakraborty Kalyan Sekhar , Bestel Shehan , Lucus Mary , Roberts Patrick , Shirvalkar Prabodh , Rawat Yadubirsingh , Larsen Thomas , Miller Heather M.-L 
Published: August 2023

Abstract

Waste management is paramount to town planning and ancient civilizations across the world have spent resources and mobilized labor for waste disposal and reuse. While the Indus Civilization is famous for its urban waste management practices, almost no work has been done on waste management practices at the Indus Era rural settlements. In this paper, using isotopic and microscopic proxies, we characterize the waste that was disposed of at the settlement of Kotada Bhadli to reconstruct the sources of waste, including animal dung, and how rural agro-pastoral settlements in Gujarat during the Indus Era systematically discarded such waste in specific locations. By characterizing waste produced at Kotada Bhadli, we are also able to reconstruct the natural environment and how the natural and cultural landscape around the settlement was exploited by the residents of settlement for their domestic and occupational needs. Our identification of the attention paid to waste disposal by the inhabitants of Kotada Bhadli adds significant data to our understanding of waste disposal as an insight into past lives.
Determining a musculoskeletal system's pre-stretched state using continuum-mechanical forward modelling and joint range optimization
Authors: Avci Okan , Röhrle Oliver 
Published: August 2023

Abstract
The biomechanics of a musculoskeletal joint system is a complex interaction of three-dimensional, inhomogeneous, anisotropic and contracting muscle tissue with nonlinear mechanical behaviour. The human-specific range of motion (RoM) of a joint system is efficiently balanced by the pre-stretch of the individual muscles, which utmost effects their contraction capability. Using a forward approach for movement analysis of the musculoskeletal system of the forearm, we developed a novel optimization process to determine the muscle fibre pre-stretch situation for a given initial arm position. We created a detailed 3D finite element model of the forearm with the flexors \biceps, \brachi, and \bradi and the extensors \triceps and \man including their distinctive fibre orientations from Visible Human Data. The optimization goal is to balance the muscle fibre pre-stretches by activating the extensors and then the flexors alternately with respect to the extension and flexion. The experimental RoM data of the elbow joint were taken from the relevant literature of a healthy person. The muscles’ stress-strain behavior of the pre-stretch optimized design shows a heterogeneous distribution, emphasizing that the structural behavior of the muscle is a complex 3D continuum problem. In addition, the optimal design are compared with handpicked design points with different muscle pre-stretch situations that also fulfill the optimization criterion. The deviations between them are large, \eg, up to 15° in motion and up to 40\,$\%$ muscle force, which underlines the importance of accurate determination of muscles’ fibre pre-stretch.
Volume of the Dentate Gyrus/CA4 Hippocampal Subfield Mediates the Interplay between Sleep Quality and Depressive Symptoms
Authors: Wang Yulin , Tian Yun , Long Zhiliang , Dong Debo , He Qinghua , Qiu Jiang , Feng Tingyong , Chen H , Tahmasia Masoud , Lei Xu 
Published: August 2023

Abstract

Emerging evidence increasingly suggests that poor sleep quality is associated with depressive symptoms. The hippocampus plays a crucial role in the interplay between sleep disturbance and depressive symptomatology e.g., accelerated hippocampal atrophy is typically seen in both insomnia disorder and depression. Hence, it is critical to examine the pivotal role of hippocampal volumes in modulating the interplay between poor sleep quality and depressive symptoms in large-scale healthy populations. To cover this research gap, the present study investigated the association between self-reported sleep quality, depressive symptoms, and hippocampal total and subfields’ volumes. Furthermore, we assessed the mediatory role of hippocampal volumes on the link between sleep quality and depressive symptoms in a large sample (N=1603) of young adults using mediation analysis. Sleep quality was correlated with self-report depressive symptoms. Moreover, sleep quality was found to be negatively associated with the volume of three hippocampal subfields, including dentate gyrus (DG), cornu ammonis fields (CA-3 and CA-4), but not correlated with total hippocampal volume. Interestingly, the volume of hippocampal DG and CA4 mediated the influence of poor sleep quality on depressive symptoms. Our findings improved our current understanding of the relationship between sleep disturbance, depressive symptomatology, and hippocampal subfields in the healthy populations. Considering the crucial role of DG in hippocampal neurogenesis, our results suggest that poor sleep quality may contribute to depression through a reduction of DG volume leading to impaired neurogenesis which is crucial for the regulation of mood.
Improving the Security of IoT Devices by Analyzing Network Attack Data with Machine Learning Algorithms
Authors: MEHTA AMAN , Tiwari Shreeya 
Published: August 2023

Abstract
This research article explores the security concerns in the Internet of Things (IoT) and aims to enhance the security of IoT devices by investigating network attacks using ordinary device network data and attack network data. The study focuses on smart healthcare systems with IoT devices and conducts botnet attacks to generate data. Statistical measures like the Pearson coefficient and entropy are used to extract relevant features from the collected data. Machine learning algorithms are employed to distinguish between normal and attack traffic, and data preprocessing techniques are applied to increase accuracy. The generated dataset is cross-evaluated with an existing dataset for authentication. The research provides insights into the behavior of normal and attack networks on IoT devices and the potential of machine learning for improving IoT device security. The article emphasizes the importance of adopting sophisticated strategies for detecting and mitigating network attacks.
Mental Health Disorders among Healthcare Workers in Sheikh Khalifa Medical City, Ajman during the COVID19 Pandemic
Authors: fouda Ghada 
Published: August 2023

Abstract
Background: The covid19 disease was declared a pandemic in March 2020. The fast spread of this pandemic put the healthcare facilities under stress and put a great burden on healthcare workers. Aim: This study aimed to protect the mental health of HCWs and to promote the social support of healthcare workers in Sheikh Khalifa Medical City Ajman (SKMCA), UAE during the COVID19 pandemic.
Subjects and Methods: this was a web-based cross-sectional analytic study where a form including four sections to assess socio- demographic characteristics, perceived stress, anxiety, and depression respectively. The form was randomly distributed via email to the selected healthcare worker. Data was collected in the period from 1st of January to end of March 2021.
Results: The mean age of healthcare workers was 37.2 ± 8.7 years, 70% were females, about 74% were married and 59.2% were nurses. The mean score of stress, depression and anxiety scale was 17.2 ± 4.8, 6 ± 3.4 and 4.8 ± 2.3 respectively. The majority of the participants (72.5) had moderate stress. Half of the participants (50.2%) had mild depression. About 55% of healthcare workers had mild anxiety. Being a female was significant risk factor for stress (OR=1.994, 95% CI (1.130-3.519) (p= 0.017), while being a nurse and allied health decrease the probability of stress (OR=0.295, 95% CI (0.125-0.699) (p=0.006); OR=0.145, 95 % CI (0.053- 0.398) (p<0.001) respectively. Being married was significantly associated with anxiety (Or=2.294, 95% CI (1.323- 3.977) (p=0.003). Being a physician increase the probability of depression (OR=6.798, 95%CI (2.140-21.592) (p=0.001).
Relationship of Central Corneal Thickness and Central Corneal Epithelial Thickness with Anthropoemetric and Biochemical Data in Individuals with Impaired Glucose Metabolism
Authors: Boyacı İhsan , Demirci Göktuğ 
Published: August 2023

Abstract
Background
Measure central corneal thickness (CCT) and central corneal epithelial thickness (CCET) with anterior segment-optical coherence tomography (AS-OCT) in individuals with impaired glucose metabolism and to analyze, the effect of impaired glucose metabolism on the cornea.
Methods
140 eyes of 70 participants, including 20 healthy controls, 17 insulin resistant, and 33 prediabetic, were evaluated by AS-OCT. Glucose metabolism was examined using a 2-hour 75 g oral glucose tolerance test and glycated haemoglobin A1c (HbA1c). Anthropoemetric measurements, physical examinations, and blood pressure were recorded of all participants. The biochemical parameters were studied.
Results
The mean age of the participants was 37.93±12.30 years, and the mean HbA1c was 5.50±0.38%. CCET measurements were significantly different and higher in the prediabetic group (p<0.01). A significant positive correlation was found between both CCETR and CCETL and age, HbA1c, and fasting plasma glucose (p<0.05). There was found a significant positive correlation was found between CCETR and total cholesterol, triglyceride, and low-density lipoprotein (p<0.05). Anthropoemetric parameters were significantly different in prediabetics (p˂0.001 and p˂0.05). There was a significant negative correlation between body fat percentage and CCT (p˂0.05). CCET showed a significant positive correlation with neck circumference (p<0.05).
Conclusions
It may be suggested that impaired metabolic processes during prediabetes may affect CCET. We believe that prediabetes detection should not be limited to HbA1c and OGTT; A multifactorial algorithm could be developed. AS-OCT may be an easily accessible and useful tool for the early diagnosis of prediabetes.
Evaluation of Adaptive Reconciliation Protocols for CV-QKD using Systematic Polar Codes
Authors: Zhang Meixiang , Wang Qiang , Son Thara , Kim Sooyoung 
Published: August 2023

Abstract

Quantum key distribution (QKD) is a secure cryptographic technology that enables two authenticated parties to share secret keys. Information reconciliation is an essential step in continuous-variable quantum key distribution (CV-QKD) protocols, which affects both the complexity and performance of the system. This paper reviews adaptive reconciliation protocols, and also proposes a new efficient scheme using systematic polar codes. Simulation results show that the proposed scheme can significantly increase reconciliation efficiency and reduce the overall computational complexity by reducing the average number of retransmissions, without significant reduction in effective secret key length.
An OpenFOAM solver for computing suspended particles in water currents
Authors: Olsen Nils R. B. , Kadia Subhojit , Pummer Elena , Hillebrand Gudrun 
Published: August 2023

Abstract
A new OpenFOAM solver has been developed for computing the spatial variation of particle concentrations in flowing water. The new solver was programmed in C ++ using OpenFOAM libraries, and the source code has been made openly available. The current article describes the coding of how the water flow and particle movements are computed. The solver is based on a Eulearian approach, where the particles are computed as concentrations in cells of a grid that resolves the computational domain. The Reynolds-averaged Navier–Stokes equations are solved by simpleFoam, using the k-ε turbulence model. The new solver uses a drift-flux approach to take the fall or rise velocity of the particles into account in a convection-diffusion equation. The model is therefore called sediDriftFoam. The results from the solver were tested on two cases with different types of particles. The first case was a sand trap with sand particles. The geometry was three-dimensional with a recirculation zone. The computed sediment concentrations in three vertical profiles compared well with earlier numerical studies and laboratory measurements. The second case was a straight channel flume with plastic particles that had a positive rise velocity. In this case, the results also compared well with the laboratory measurements.