bluuebunny/crossref_metadata_2025_split huggingface dataset:
नेपालको तराईका खवास जातिको सामाजिक – सांस्कृतिक अवस्था
Authors: माझी माेहन लाल 
Published: April 2023

नेपालको प्राचीन समयमा आदिवासी जनजातिहरू मध्येको खवास जाति हो । यो जातिको आदि उत्पति पर्वतमा नै थियो । खवास अनुभूति अनुसार निजहरु प्रारम्भ क्षत्रीय नै थियो । यो जाति नेपाली हो । यस जातिको आफ्नै मातृभाषा रहेको छ । यो जाति नेपालको तराई भागमा समतल भूमिमा अन्य तराई जनजाति सरह निकै लामो समय देखि बसोवास गर्दै आएको पाइन्छ । यस जातिलाई तराईवासी पिछिडिएको जाति भनिन्छ । यस जातिको सामाजिक र सांस्कृतिक अवस्थाकोे राष्ट्रिय स्तरमा परिचय गराउन र त्यस विषयमा विविध पक्ष उल्लेख गरिएकाे छ ।अध्ययन तथा खोज गर्ने क्रममा प्राथमिक स्रोत (primary source) तथा द्वितीय स्रोत (secondary source), दुवै स्रोतहरूको प्रयोग गरिएको भए तापनि मुलतः प्राथमिक स्रोत (primary source) बाट अध्ययन गरिएको छ । प्राथमिक तथ्याङ्क संकलन विधिलाई नै महत्वपूर्ण मानिएको छ । प्राथमिक स्रोतका लागि वसोवास क्षेत्रका वुढापाका, शिक्षित, युवा, महिला र विशेष रूपमा राजनीतिक व्यक्ति र जनप्रतिनिधि (महिला तथा पुरूष) हरूसँग प्रत्यक्ष रूपमा प्रश्नहरू गरी अन्तरवार्ता लिइएको छ । व्यक्तिगत र सामूहिकमा सामाजिक र साँस्कृतिक अवस्थाको वारेमा अन्तरवार्ता समेत गरिएको छ । यो खवास जातिको उत्पत्ति, सांस्कृतिक विकास र सामाजिक अवस्थामा भएको परिवर्तन बारेमा विश्लेशण गरिएकोे छ ।
PENGARUH PEMBERIAN PUPUK ORGANIK CAIR EKSTRAK DAUN GAMAL (Gliricidia sepium) TERHADAP PERTUMBUHAN TANAMAN KANGKUNG DARAT (Ipomoea reptans Poir.)
Authors: Razali Imam , Fithria Dewi 
Published: April 2023

<p>Penelitian pengaruh pemberian pupuk organik cair ekstrak daun gamal (<em>Gliricidia sepium</em>) terhadap pertumbuhan tanaman kangkung darat (<em>Ipomoea reptans</em> Poir.) dilakukan di Desa Alue Ambang, Kecamatan Teunom, Kabupaten Aceh Jaya dimulai dari bulan Agustus sampai November 2022. Rancangan yang digunakan adalah Rancangan Acak Kelompok (RAK) non faktorial yang terdiri dari 3 taraf perlakuan dan 3 ulangan, sehingga diperoleh 9 unit percobaan. Perlakuan yang diberikan adalah G<sub>0</sub> (kontrol/tanpa perlakuan), G<sub>1</sub> (20 ml POC.1<sup>-1 </sup>air), dan G<sub>2</sub> (25 ml POC.1<sup>-1 </sup>air). Hasil penelitian ini memberikan pengaruh nyata terhadap tinggi tanaman 14 HST dengan perlakuan G<sub>2</sub> (25 ml POC.1<sup>-1 </sup>air).</p><p>Kata kunci: ekstrak daun gamal, konsentrasi, tanaman kangkung</p>
On Absolute Valued Algebras with a Central Algebraic Element and Satisfying Some Identities
Authors: Moutassim Abdelhadi 
Published: April 2023

In [8], we have proven that if is an absolute valued algebra containing a nonzero central algebraic element, then is a pre-Hilbert algebra. Here we show that is finite dimensional in the following cases:
1) A satisfies (x2, x, x) = 0 or (x, x, x2) = 0,
2) A satisfies (x2, x2, x) = 0 or (x, x2, x2) = 0, .
In these cases A is isomorphic to R, C, H or O.
Role-playing the Self – Trans Self-Expression, Exploration, and Embodiment in Live Action Role-Playing Games
Authors: Baird Josephine 
Published: April 2023

Accounts of trans people using role-playing games (RPGs) as a safer space to “try out” another way to be gen- dered can be found in numerous sites – from the memetic, to the anecdotal, to the academic. Using autoethnography and post-structuralist queer theory of performativity in combination with scholarly perspectives of RPGs as sites for potential- ly transformative experiences, I consider the ways in which live-action role-playing games (larps) might help trans peo- ple express, explore, and embody their subjectivity. I argue that despite there being a relatively small (though growing) number of larps designed to encourage players to consider gender and sexuality norms in society, there remains no larp that intentionally allows trans people (or those questioning their gender) to consider their gender subjectivity therein.
Scholarly perspectives on larps suggest that they might provide a site for the simulation of complex socio-cultural dy- namics, a space to adopt different social roles, and the alibi and scaffolding to do so in a way that is validating with a community of like-minded role-players (Deterding 2018; Bowman and Hugaas 2021). I present examples of larps that, either by design or not, seem to have provided opportunities for gender role-play and transformative experiences for some trans players. I consider the possible limitations the embodied experience of larps -- as opposed to digital and table-top RPGs (TRPGs) -- might have in allowing such exploration for some trans players, particularly in potentially transphobic play environments. I argue howev- er, that the embodied nature of larps might also provide an opportunity to explore gender role-play in such a way that allows for the validation of more diverse physical and social gender presentations, as well as the rehearsal thereof in a safer space. I present accounts of trans people -- including my own autoethnography -- using role-playing games, larps, and other activities/ environments not necessarily consciously designed for the purpose of gender exploration as the basis for how this might be designed for intentionally in larps. I conclude by proposing to design a larp that could provide an opportunity to express, ex- plore, and embody non-normative gender, and I pose a series of questions that I believe such a design should seek to answer.
International Journal of Role-playing 12 -- Full Issue -- IJRP
Authors: White William J. , Torner Evan , Bowman Sarah Lynne , Iuama Tadeu Rodrigues , Falcão Luiz , Baker Marissa , Martinolli Pascal , Grasmo Hanne , Stenros Jaakko , Mehrstam Christian 
Published: April 2023

IJRP 12: Full Issue
Table of Contents
William J. White, Evan Torner, and Sarah Lynne Bowman,“Editorial: The Social Epistemology of Analog Role-Playing Game Studies”
Reflections on the interdisciplinary and heterogeneous nature of role-playing games studies, as evident in the five uniquely distinct articles in Issue 12.
Tadeu Rodrigues Iuama and Luiz Falcão, “Analog Role-Playing Game Studies: A Brazilian Overview”
An overview of the history of role-playing games and their respective game communities in Brazil, as well as the development of role-playing game study scholarship, including research on RPGs in education.
Marissa Baker, “An Analysis of the Literature Surrounding the Intersection of Role-Playing Games, Race, and Identity”
A review and examination of a body of multidisciplinary scholarship on representation and race in fantasy RPGs such as Dungeons & Dragons and World of Warcraft.
Pascal Martinolli, “A Scholarly Character Sheet to Frame Learning Activities and Improve Engagement”
An evaluation of the use of role-playing game inspired character sheets in a graduate seminar on library instruction to assess the participants’ knowledge, present the curriculum, and measure the their progress.
Hanne Grasmo and Jaakko Stenros, “Nordic Erotic Larp: Designing for Sexual Playfulness”
Mapping, organizing, and understanding the phenomena of erotic larp design through a systemic examination of 25 design abstracts of Nordic art larps from the last decade.
Christian Mehrstam, “Recomposing Lovecraft: Genre Emulation asAutopoiesis in the First Edition of Call of Cthulhu”
An examination of how genre is emulated in the first edition of Call of Cthulhu (1981), analyzing the game’s potential to answer social needs during the Reagan era.
International Journal of Role-playing 9 -- Full Issue -- IJRP
Authors: Torner Evan , Murdock Russell , Leonard Diana J. , Thurman Tessa , Atwater Brodie , Rowland Alexis , Cox Jason 
Published: April 2023

IJRP 9: Special Issue — Living Games Conference 2018
Table of Contents
Evan Torner, “Editorial”
This special issue contains four articles chosen from among those presented at the Living Games Conference at Northeastern University in Peabody, MA, on May 17-20, 2018.
Russell Murdock, “Legal Liability in Live Action Role-Playing: The Law is Dark and Full of Terrors”
This paper explores the legal liabilities and risks associated with running a live-action role-playing game (larp), including issues related to alcohol consumption, employee behavior, and personal injury.
Diana J. Leonard and Tessa Thurman, “Bleed-out on the Brain: The Neuroscience of Character-to-Player Spillover in Larp”
This article pairs emerging neuroscience theory and research with classic psychological models of emotion and motivation to examine the causes and consequences of the important larp phenomenon of bleed-out.
Brodie Atwater and Alexis Rowland, “Developing a Framework of Larp Counseling”
This paper outlines the purpose and challenges of the role of larp counselor in order to discuss the need for standardization due to liabilities and expectations of care. The authors propose a three part guide containing a code of ethics, procedures, and best practices.
Jason Cox, “Documenting Larp as an Art of Experience”
This article approaches larp documentation and representation by foregrounding player experiences over the narrative created by the designers. The author discusses the development of The Magischola Museum website, designed to house artifacts from the larp series New World Magischola.
A importância da correlação entre humanização e tecnologia nas unidades de terapia intensiva: uma revisão narrativa
Authors: Cardoso Ana Carolina Borges , Reis Juliana Serafim dos , Santos Marcos Vinícios Ferreira dos 
Published: April 2023

Na construção histórico-político-social as unidades de terapia intensiva (UTI) moldaram se em locais onde a técnica se sobressai com relação aos aspectos relacionados ao cuidado, já que, os profissionais atuantes estão sempre emergidos por aparatos tecnológicos, o que desperta a atenção para os debates acerca do cuidado humanizado. Nesse âmbito, a utilização das tecnologias e sua implementação nos serviços de saúde não deve anular o contato do profissional de saúde com o paciente, pois é visível que ele é inerente a prática o cuidado interpessoal, essencial e complementar as tecnologias. Ademais, as tecnologias leves realizam a promoção da humanização no cuidado, afirmando as relações entre o profissional e o paciente, e sua inserção neste processo fortalece e qualifica o processo de trabalho do profissional, nos pressupostos da autonomia, protagonismo e corresponsabilidade, realizando transformações nos modos de relação e de comunicação entre os sujeitos. Assim, a humanização, na saúde, se liga às questões éticas relacionadas ao ato de cuidar de pacientes, para melhoria nas relações entre os envolvidos nesse processo e nas condições de trabalho. No trabalho vigente, será abordado a importância da correlação entre humanização e tecnologia nas unidades de terapia intensiva. O objetivo deste estudo foi analisar a importância da correlação entre humanização e tecnologia nas unidades de terapia intensiva, abordando as vantagens e desvantagens da informatização no gerenciamento hospitalar com foco em UTI e nas questões éticas ligadas ao ato de cuidar de pacientes, para melhoria nas relações entre os envolvidos nesse processo e nas condições de trabalho.
Impactos da pandemia de COVID-19 no exame citopatológico do colo uterino no Pará
Authors: Silva Gabriela Fernandes Moreira da , Branco Letícia Lima , Cavalcante Thaís Farias 
Published: April 2023

A pandemia do COVID-19 alterou o sistema de saúde para que houvesse o atendimento prioritário de pacientes suspeitos ou infectados pelo coronavírus, impactando na descontinuação de procedimentos de rastreamento como o exame citopatológico do colo uterino. O estudo teve como objetivo identificar o impacto da pandemia pelo COVID-19 no rastreamento do câncer de colo de útero (CCU) no estado do Pará, Brasil. Trata-se de uma pesquisa descritiva correlacionando dados registrados no Departamento de Informática do Sistema Único de Saúde (DATASUS). Nesse sentido, foi analisado o número de exames citopatológicos do colo uterino feitos de março de 2019 a fevereiro de 2020 (pré-pandemia) e de março do ano de 2020 até fevereiro de 2021 (pandemia). A partir disso, correlacionou-se o número de exames realizados com o número de casos de COVID-19 registrados no estado do Pará de março de 2020 a fevereiro de 2021, no site de monitoramento da secretaria de saúde pública do estado do Pará. Observou-se que houve uma diminuição significativa na quantidade de exames para rastreamento efetuados durante a pandemia, 45% em relação ao período pré-pandemia, assim como notou-se uma correlação negativa entre a pandemia e a realização do exame de rastreio. Dessa forma, a pandemia impactou negativamente no rastreamento de CCU, o que pode levar a diagnósticos e tratamentos tardios, necessitando, portanto, da promoção de estratégias para aumentar a cobertura de rastreio de CCU na atenção primária.
Real or fake? Measuring the impact of protein annotation errors on estimates of domain gain and loss events
Authors: Kress Arnaud , Poch Olivier , Lecompte Odile , Thompson Julie D. 
Published: April 2023

Protein annotation errors can have significant consequences in a wide range of fields, ranging from protein structure and function prediction to biomedical research, drug discovery, and biotechnology. By comparing the domains of different proteins, scientists can identify common domains, classify proteins based on their domain architecture, and highlight proteins that have evolved differently in one or more species or clades. However, genome-wide identification of different protein domain architectures involves a complex error-prone pipeline that includes genome sequencing, prediction of gene exon/intron structures, and inference of protein sequences and domain annotations. Here we developed an automated fact-checking approach to distinguish true domain loss/gain events from false events caused by errors that occur during the annotation process. Using genome-wide ortholog sets and taking advantage of the high-quality human and Saccharomyces cerevisiae genome annotations, we analyzed the domain gain and loss events in the predicted proteomes of 9 non-human primates (NHP) and 20 non-S. cerevisiae fungi (NSF) as annotated in the Uniprot and Interpro databases. Our approach allowed us to quantify the impact of errors on estimates of protein domain gains and losses, and we show that domain losses are over-estimated ten-fold and three-fold in the NHP and NSF proteins respectively. This is in line with previous studies of gene-level losses, where issues with genome sequencing or gene annotation led to genes being falsely inferred as absent. In addition, we show that insistent protein domain annotations are a major factor contributing to the false events. For the first time, to our knowledge, we show that domain gains are also over-estimated by three-fold and two-fold respectively in NHP and NSF proteins. Based on our more accurate estimates, we infer that true domain losses and gains in NHP with respect to humans are observed at similar rates, while domain gains in the more divergent NSF are observed twice as frequently as domain losses with respect to S. cerevisiae. This study highlights the need to critically examine the scientific validity of protein annotations, and represents a significant step toward scalable computational fact-checking methods that may 1 day mitigate the propagation of wrong information in protein databases.
System metabolic engineering of Escherichia coli W for the production of 2-ketoisovalerate using unconventional feedstock
Authors: Carranza-Saavedra Darwin , Torres-Bacete Jesús , Blázquez Blas , Sánchez Henao Claudia Patricia , Zapata Montoya José Edgar , Nogales Juan 
Published: April 2023

Replacing traditional substrates in industrial bioprocesses to advance the sustainable production of chemicals is an urgent need in the context of the circular economy. However, since the limited degradability of non-conventional carbon sources often returns lower yields, effective exploitation of such substrates requires a multi-layer optimization which includes not only the provision of a suitable feedstock but the use of highly robust and metabolically versatile microbial biocatalysts. We tackled this challenge by means of systems metabolic engineering and validated Escherichia coli W as a promising cell factory for the production of the key building block chemical 2-ketoisovalerate (2-KIV) using whey as carbon source, a widely available and low-cost agro-industrial waste. First, we assessed the growth performance of Escherichia coli W on mono and disaccharides and demonstrated that using whey as carbon source enhances it significantly. Second, we searched the available literature and used metabolic modeling approaches to scrutinize the metabolic space of E. coli and explore its potential for overproduction of 2-KIV identifying as basic strategies the block of pyruvate depletion and the modulation of NAD/NADP ratio. We then used our model predictions to construct a suitable microbial chassis capable of overproducing 2-KIV with minimal genetic perturbations, i.e., deleting the pyruvate dehydrogenase and malate dehydrogenase. Finally, we used modular cloning to construct a synthetic 2-KIV pathway that was not sensitive to negative feedback, which effectively resulted in a rerouting of pyruvate towards 2-KIV. The resulting strain shows titers of up to 3.22 ± 0.07 g/L of 2-KIV and 1.40 ± 0.04 g/L of L-valine in 24 h using whey in batch cultures. Additionally, we obtained yields of up to 0.81 g 2-KIV/g substrate. The optimal microbial chassis we present here has minimal genetic modifications and is free of nutritional autotrophies to deliver high 2-KIV production rates using whey as a non-conventional substrate.
Interleukin-15 deficient rats have reduced osteopontin at the maternal-fetal interface
Authors: Baines Kelly J. , Klausner Michelle S. , Patterson Violet S. , Renaud Stephen J. 
Published: April 2023

Introduction: Uterine Natural Killer (NK) cells are the predominant immune cells within the decidua during early pregnancy. These cells are thought to regulate aspects of decidualization and placental development, but their functions remain poorly characterized, especially in species with deeply invading trophoblasts such as humans and rats. Interleukin-15 (IL-15) is a cytokine required for NK cell development and survival. IL-15 mutant (IL15Δ/Δ) rats lack NK cells and exhibit altered placental development with precocious trophoblast invasion. In this study, we profiled gene expression differences between wild-type and IL15Δ/Δ implantation sites to reveal candidate factors produced by uterine NK cells that may regulate placentation and trophoblast invasion.Methods: Clariom S gene expression profiling was performed using implantation sites collected from pregnant wild-type and IL15Δ/Δ rats on gestational day 9.5. Levels and localization of perforin and osteopontin in implantation sites from wild-type and IL15Δ/Δ rats were further analyzed. The effect of osteopontin on the invasive capacity of rat trophoblasts was evaluated using Matrigel-based Transwell assays.Results: There were 257 genes differentially expressed between wild-type and IL15Δ/Δ implantation sites on gestational day 9.5, including decreased expression of various NK cell markers in IL15Δ/Δ rats, as well as Spp1, which encodes osteopontin. In wild-type rats, osteopontin was present within the decidua basalis and adjacent to the primitive placenta, and osteopontin colocalized with the NK cell marker perforin. Osteopontin was also detectable in uterine glands. Conversely, in IL15Δ/Δ rats, osteopontin and perforin were not readily detectable in the decidua despite robust osteopontin levels in uterine glands. Neutralization of osteopontin in media conditioned by cells isolated from the decidua decreased invasion of rat trophoblasts, suggesting that reduced levels of osteopontin are unlikely to account for the precocious trophoblast invasion in IL15Δ/Δ rats.Conclusion: Osteopontin is expressed by NK cells at the maternal-fetal interface in rats and may contribute to modulation of trophoblast invasion.
Quantitative assessment of retinal microvascular remodeling in eyes that underwent idiopathic epiretinal membrane surgery
Authors: Shen Yingjiao , Ye Xin , Tao Jiwei , Zhao Chenhao , Xu Zhaokai , Mao Jianbo , Chen Yiqi , Shen Lijun 
Published: April 2023

Purpose: To explore the surgical outcomes of the macular microvasculature and visual function in eyes with idiopathic epiretinal membrane (iERM) using spectral-domain optical coherence tomography angiography (SD-OCTA).Methods: This observational, cross-sectional study included 41 participants who underwent iERM surgery with a 3-month (3M) follow-up. Forty-one healthy eyes formed the control group. The assessments included best-corrected visual acuity (BCVA) and mean sensitivity (MS) by microperimetry and SD-OCTA assessment of vessel tortuosity (VT), vessel density (VD), foveal avascular zone, and retinal thickness (RT).Results: The findings showed statistically significant differences in VT, foveal avascular zone parameters, RT, BCVA, and MS between the iERM and control groups (p &lt; 0.05). After iERM surgery, the macular VT, SCP VD, and RT decreased significantly (p &lt; 0.01) while the DCP VD increased (p = 0.029). The BCVA improved significantly (p &lt; 0.001) and was associated with the MS (rs = −0.377, p = 0.015). MS was associated with the SCP VD and RT at 3M (SCP VD rs = 0.511, p = 0.001; RT rs = 0.456, p = 0.003). In the superior quadrant, the MS improved significantly (p &lt; 0.001) and the improvement of MS was associated with the reduction of VT (β = −0.330, p = 0.034).Conclusion: Microcirculatory remodeling and perfusion recovery were observed within 3 months after iERM surgery. VT was a novel index for evaluating the morphology of the retinal microvasculature in eyes with iERM and was associated with MS in the superior quadrant.
Insights on mapping Industry 4.0 and Education 4.0
Authors: Chakraborty Sourojeet , Gonzalez-Triana Yris , Mendoza Jorge , Galatro Daniela 
Published: April 2023

IntroductionThe fourth industrial revolution, or Industry 4.0 (I.D. 4.0), has radically empowered professionals to revamp skills and technologies, to match ever-evolving industry demands. Education 4.0 (E.D. 4.0) is an integral education framework, strategically designed to align with I.D. 4.0 needs. The present work presents high-level insights on mapping I.D. 4.0 to E.D. 4.0, by successfully analyzing the four key existing components of E.D. 4.0, namely, learning methods, competencies, infrastructure and information and communication technologies (ICT).MethodsResearch questions are formulated along themes aiming to standardize the E.D. 4.0 framework and identify effectiveness and implementation challenges. These posed questions are addressed by performing an exhaustive bibliometric analysis on the associated literature, by clustering relevant publications by field, year, and geography. We employed the search engines Scopus, Science Direct, and IEEE in a period between January and June of 2022.ResultsNetwork maps evidence the implementation of E.D. 4.0 elements with no formal and universally adopted framework to map with I.D. 4.0. There is an increasing interest and support from researchers and education institutions in preparing a skilled workforce for I.D. 4.0. Trends of E.D&gt; 4.0-related published articles reveal more implementation efforts in developed countries compared to developing countries.DiscussionOur results demonstrate a lack of any currently existent, standardized, and universally accepted framework for mapping I.D. 4.0 to E.D. 4.0, despite trends showing a sharp rise towards incorporating E.D. 4.0 initiatives recently into university curricula. Our analysis procedure can serve as a protocol to define E.D. 4.0 in a more specific context, in an ever-changing global workspace. While unbalanced implementation attempts on how extensively E.D. 4.0 components have been defined and adopted (including discrepancies in implementation policies among countries, and across disciplines), further rigorous assessments are needed to critically assess the necessary requirements and effectiveness, for standardization and implementation a global mapping framework.