bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating the causal effects of multiple intermittent treatments with application to COVID-19
Authors: Hu Liangyuan , Ji Jiayi , Joshi Himanshu , Scott Erick R , Li Fan 
Published: August 2023

Abstract
To draw real-world evidence about the comparative effectiveness of multiple time-varying treatments on patient survival, we develop a joint marginal structural survival model and a novel weighting strategy to account for time-varying confounding and censoring. Our methods formulate complex longitudinal treatments with multiple start/stop switches as the recurrent events with discontinuous intervals of treatment eligibility. We derive the weights in continuous time to handle a complex longitudinal data set without the need to discretise or artificially align the measurement times. We further use machine learning models designed for censored survival data with time-varying covariates and the kernel function estimator of the baseline intensity to efficiently estimate the continuous-time weights. Our simulations demonstrate that the proposed methods provide better bias reduction and nominal coverage probability when analysing observational longitudinal survival data with irregularly spaced time intervals, compared to conventional methods that require aligned measurement time points. We apply the proposed methods to a large-scale COVID-19 data set to estimate the causal effects of several COVID-19 treatments on the composite of in-hospital mortality and intensive care unit (ICU) admission relative to findings from randomised trials.
Feasibility of laparoscopic microwave ablation of caudate tumors: a case series
Authors: White McKenzie J , Nelson Alexander T , Wothe Jillian , Ankeny Jacob S , Brauer David , Larocca Christopher J , Jensen Eric H 
Published: August 2023

Abstract
Microwave ablation of liver tumors allows preservation of liver parenchyma with good oncologic outcomes. However, ablation of tumors in the caudate lobe is particularly challenging. Adjacent critical anatomy, particularly the biliary hilum, has led to caudate location being considered a relative contraindication to ablation. To date, no series have described laparoscopic microwave ablation of caudate tumors of the liver. We describe our early experience with laparoscopic microwave ablation of caudate tumors. In this retrospective review of a prospectively maintained single-institution database, six patients with six primary or secondary caudate tumors underwent laparoscopic microwave ablation with no complications. At a median follow-up of 10.5 months, five out of six patients are free of caudate recurrence. Laparoscopic microwave ablation of caudate tumors is feasible. Long-term follow-up is needed to determine if local recurrence risk is higher than in other anatomical segments.
Spontaneous rectus sheath and retroperitoneal haemorrhage secondary to enoxaparin injections
Authors: Sohail Aroon , Naqvi Jawad , Wilson Paul 
Published: August 2023

Abstract
Bleeding from enoxaparin is a recognized side effect; however, the formation of rectus sheath and retroperitoneal haematomas is a rare and potentially life-threatening complication. Patients may present insidiously and without symptoms; therefore, high clinical suspicion of a bleeding intra-abdominal haematoma should be suspected in patients with a combination of clinical and biochemical evidence of bleeding. Treatment is patient dependent and is either interventional or conservative in approach. Clinicians should be mindful when prescribing high-dose enoxaparin with further caution advised for at-risk patients.
‘Budapest’s Gift to the Movies’: Franziska Gaal’s Film Career in 1930s Europe and Hollywood
Authors: Dämon Hanja 
Published: August 2023

Abstract
Hungarian-born actress Franziska (or Franciska) Gaal was an interwar star whose film career spanned different countries and continents. Contemporary trade press and newspaper articles reveal her international fame during the 1930s, and trace her attempts to conquer Hollywood, where the studio system dictated that she lose weight and dye her hair. As she was unable to continue her career in Europe due to her Jewish heritage, this article examines her trajectory in Europe and the United States in the context of exile. It also interrogates how one of Europe’s top stars for an entire decade could fade from public memory and drift into oblivion, especially in the German-speaking countries where she was once so successful.
Photoswitchable molecular glue for RNA: reversible photocontrol of structure and function of the ribozyme
Authors: Dohno Chikara , Kimura Maki , Fujiwara Yusuke , Nakatani Kazuhiko 
Published: August 2023

Abstract
Single-stranded RNA folds into a variety of secondary and higher-order structures. Distributions and dynamics of multiple RNA conformations are responsible for the biological function of RNA. We here developed a photoswitchable molecular glue for RNA, which could reversibly control the association of two unpaired RNA regions in response to light stimuli. The photoswitchable molecular glue, NCTA, is an RNA-binding ligand possessing a photoisomerizable azobenzene moiety. Z-NCTA is an active ligand for the target RNA containing 5′-WGG-3′/5′-WGG-3′ (W = U or A) site and stabilizes its hybridized state, while its isomer E-NCTA is not. Photoreversible isomerization of NCTA enabled control of the secondary and tertiary structure of the target RNA. The RNA-cleaving activity of hammerhead ribozyme, where appropriate RNA folding is necessary, could be reversibly regulated by photoirradiation in cells treated with NCTA, demonstrating precise photocontrol of RNA structure and function by the photoswitchable molecular glue.
Strategies to identify and edit improvements in synthetic genome segments episomally
Authors: Rudolph Alexandra , Nyerges Akos , Chiappino-Pepe Anush , Landon Matthieu , Baas-Thomas Maximilien , Church George 
Published: August 2023

Abstract
Genome engineering projects often utilize bacterial artificial chromosomes (BACs) to carry multi-kilobase DNA segments at low copy number. However, all stages of whole-genome engineering have the potential to impose mutations on the synthetic genome that can reduce or eliminate the fitness of the final strain. Here, we describe improvements to a multiplex automated genome engineering (MAGE) protocol to improve recombineering frequency and multiplexability. This protocol was applied to recoding an Escherichia coli strain to replace seven codons with synonymous alternatives genome wide. Ten 44 402–47 179 bp de novo synthesized DNA segments contained in a BAC from the recoded strain were unable to complement deletion of the corresponding 33–61 wild-type genes using a single antibiotic resistance marker. Next-generation sequencing (NGS) was used to identify 1–7 non-recoding mutations in essential genes per segment, and MAGE in turn proved a useful strategy to repair these mutations on the recoded segment contained in the BAC when both the recoded and wild-type copies of the mutated genes had to exist by necessity during the repair process. Finally, two web-based tools were used to predict the impact of a subset of non-recoding missense mutations on strain fitness using protein structure and function calls.
Let's make it clear: systematic exploration of mitochondrial DNA– and RNA–protein complexes by complexome profiling
Authors: Potter Alisa , Cabrera-Orefice Alfredo , Spelbrink Johannes N 
Published: August 2023

Abstract
Complexome profiling (CP) is a powerful tool for systematic investigation of protein interactors that has been primarily applied to study the composition and dynamics of mitochondrial protein complexes. Here, we further optimized this method to extend its application to survey mitochondrial DNA- and RNA-interacting protein complexes. We established that high-resolution clear native gel electrophoresis (hrCNE) is a better alternative to preserve DNA– and RNA–protein interactions that are otherwise disrupted when samples are separated by the widely used blue native gel electrophoresis (BNE). In combination with enzymatic digestion of DNA, our CP approach improved the identification of a wide range of protein interactors of the mitochondrial gene expression system without compromising the detection of other multiprotein complexes. The utility of this approach was particularly demonstrated by analysing the complexome changes in human mitochondria with impaired gene expression after transient, chemically induced mitochondrial DNA depletion. Effects of RNase on mitochondrial protein complexes were also evaluated and discussed. Overall, our adaptations significantly improved the identification of mitochondrial DNA– and RNA–protein interactions by CP, thereby unlocking the comprehensive analysis of a near-complete mitochondrial complexome in a single experiment.
Modelling perception as a hierarchical competition differentiates imagined, veridical, and hallucinated percepts
Authors: Sulfaro Alexander A , Robinson Amanda K , Carlson Thomas A 
Published: August 2023

Abstract
Mental imagery is a process by which thoughts become experienced with sensory characteristics. Yet, it is not clear why mental images appear diminished compared to veridical images, nor how mental images are phenomenologically distinct from hallucinations, another type of non-veridical sensory experience. Current evidence suggests that imagination and veridical perception share neural resources. If so, we argue that considering how neural representations of externally generated stimuli (i.e. sensory input) and internally generated stimuli (i.e. thoughts) might interfere with one another can sufficiently differentiate between veridical, imaginary, and hallucinatory perception. We here use a simple computational model of a serially connected, hierarchical network with bidirectional information flow to emulate the primate visual system. We show that modelling even first approximations of neural competition can more coherently explain imagery phenomenology than non-competitive models. Our simulations predict that, without competing sensory input, imagined stimuli should ubiquitously dominate hierarchical representations. However, with competition, imagination should dominate high-level representations but largely fail to outcompete sensory inputs at lower processing levels. To interpret our findings, we assume that low-level stimulus information (e.g. in early visual cortices) contributes most to the sensory aspects of perceptual experience, while high-level stimulus information (e.g. towards temporal regions) contributes most to its abstract aspects. Our findings therefore suggest that ongoing bottom-up inputs during waking life may prevent imagination from overriding veridical sensory experience. In contrast, internally generated stimuli may be hallucinated when sensory input is dampened or eradicated. Our approach can explain individual differences in imagery, along with aspects of daydreaming, hallucinations, and non-visual mental imagery.
Dietary, macronutrient, micronutrient, and nutrigenetic factors impacting cardiovascular risk markers apolipoprotein B and apolipoprotein A1: a narrative review
Authors: Nacarelli Gregory S , Fasolino Tracy , Davis Stephanie 
Published: August 2023

Abstract
Genetic predisposition and dietary factors can impact cardiovascular disease (CVD) risk. Two important markers in assessing CVD risk are apolipoprotein (apo) B and apolipoprotein A1 plasma levels. These markers are measured as a ratio, with a high apoB:apoA1 ratio associated with increased CVD risk. Dietary and lifestyle recommendations are the cornerstone of managing primary and secondary CVD risk-mitigation strategies. One way to assess the impact of various dietary and lifestyle interventions on CVD risk is to evaluate the changes in CVD risk markers, such as apoB, apoA1, and apoB:apoA1 ratio. Various human studies have demonstrated the impact of dietary, macronutrient, and micronutrient interventions on apoB and apoA1 status. This review aims to elucidate dietary, macronutrient, micronutrient, and nutrigenetic considerations for impacting apoB and apoA1 levels. A low-carbohydrate, high-saturated-fat diet, low fiber intake, low vitamin and mineral intake, and zinc and iron deficiency are associated with an elevated apoB:apoA1 ratio. The Mediterranean diet, vegan diet, fermented dairy products, lower sugar intake, higher protein intake, higher polyunsaturated fat intake, and an omega-3–rich diet are associated with a decreased apoB:apoA1 ratio. Micronutrients associated with a decreased apoB:apoA1 ratio include vitamin D sufficiency, increased serum vitamin C, and magnesium. Variants in the APOE, APOA1, and FADS2 genes may alter the apoB:apoA1 ratio in response to various dietary interventions. When accounting for factors that may favorably alter the apoB:apoA1 ratio, researchers should consider a healthy diet sufficient in polyunsaturated fats, vitamins, minerals, trace minerals, and lower excess sugars.
Promoting health and wellbeing at health precincts: a rapid review of four built environment audit tools for assessing health precincts
Authors: Liu Edgar , Lagisz Malgorzata , Reid Andrew , de Leeuw Evelyne 
Published: August 2023

Abstract
In Australia, ‘health precincts’ are increasingly touted as the new innovation hub. They perform important health care functions, and often incorporate vital research and innovation roles. As such, they do not only assist patients in recovery but also promote health and wellbeing to safeguard their patients, visitors and workers. Although their functions in disease care are unquestionable, less is known about whether and how health precincts promote health and wellbeing. Over the past decade, several audit tools have been developed to assess the degrees of, first, sustainability and, more recently, health promotion of individual buildings. No comparable audit tools, however, exist that can account for the role of health promotion of multi-building and multi-functional spaces like health precincts. This paper reports on a rapid review on the suitability of four existing built environment audit tools—the Health Facility Audit Tool, health impact assessments, the WELL Building Standard checklist, and the Built Environment Assessment Tool—for assessing the promotion of health in health precincts. Twenty-six papers published in English between 2010 and 2022 were included in this rapid review, many (n = 15) of which were critical assessment of one of the four tools. Our findings show a lack of application of such tools at the precinct scale, with many instead focusing on the city or metropolitan scale (n = 7) or individual office buildings (n = 5). For each audit tool, we report on the benefits and drawbacks highlighted. We conclude with suggestions on how these audit tools may be adapted for application at health precincts.
The Millennial Woman in Bollywood
Authors: Rao Maithili 
Published: August 2023

Abstract
The subtitle says it all: how and why Bollywood found it worthwhile to explore the reality of the millennial women who are thriving in India—small part of the demographics but very influential. Advertising discovered women as choosy consumers and influencers. The Hindi film Heroine is a brand and brand ambassador. The market met the needs of contemporary women who are independent, with freer attitudes to relationships, including pre-marital sex and life choices. Romcoms reflect this new found freedom, defying patriarchy that still defines our society. Globalization is culturally irreversible. From the 1990s onwards, Bollywood has responded to globalization in a paradoxical way: fear of losing our cultural identity and strong desire to integrate with global trends. It results in popular cinema becoming glocal. Bollywood has found it creatively and commercially satisfying to explore all facets of this new fascinating creature, the millennial woman who is more than a buzzword. With the injection of energy by ambitious Indie filmmakers, Bollywood now celebrates nonconformists, subversives. woman the hero, women the professional … in engaging and enlightening ways. It applauds young women who unequivocally said No means No. Most daringly, iconic characters like Choti Bahu, Paro, and Chandramukhi transformed into today’s women with the power to change their lives. This is due to the creative vigour infused into the mainstream by indie filmmakers with vision and the will to tell stories in their own way.
Introduction
Authors: Rao Maithili 
Published: August 2023

Abstract
The chapter introduces the idea of the millennial woman as a 21st-century Indian woman attempting to express her identity on her own terms. Data on the ground shows that the increased participation of women in the workforce, in numbers and professions, has enabled her emergence. Bollywood and popular culture have been influential in making the millennial woman acceptable. The idea has been mainstreamed by recent films and female stars and has percolated into small towns. Stars like Deepika Padukone and Anushka Sharma exude youth, attitude, and achievement carried with panache, function as ‘brand ambassadors’—as themselves and through commodities they endorse. Consumption may be key to making of the self, but the millennial woman is not merely a narcissistic pleasure seeker. The recent anti-CAA protests have shown she is political and a defender of social values.
Woman the Hero
Authors: Rao Maithili 
Published: August 2023

Abstract
The female hero in Bollywood has emerged as a response to the clamour for meaningful representation of women in cinema. Either a nurturing or destructive force, she draws on the mythological Durga and Kali—the two faces Shakti. Women heroes drive the action and narrative. Kahani (2012) and NH10 (2015) pivot on the journeys of women in search of revenge and justice, who much like the archetypical hero, enter unknown and dangerous terrains. Vidya (Kahani, 2012) acts alone to resolve the mystery of her husband’s disappearance. Meera (Anushka Sharma, NH10, 2015) is an urban professional who confronts entrenched patriarchal forces at Delhi’s borders. Heroes can be seemingly ordinary women who overcome hurdles—societal and personal. Deepika Padukone’s Chhapaak (2020) based on acid attack survivor Laxmi Agarwal celebrates her transformation from victim to compassionate activist. Domestic worker Chanda’s dream is to end the cycle of poverty by enabling her daughter to become a district collector (Swara Bhaskar, Nil Battey Sannata, 2015). Secret Superstar (2017) celebrates the mutually empowering bond between the 15-year-old Insia (Zaira Wasim) and her mother who battle the everyday ugliness of patriarchy within the home to liberate themselves. Biopics celebrate the lives of women in male dominated sports (Dangal, 2016; Mary Kom, 2014). Neerja (2016) and Raazi (2018) are about real-life heroes in previously male territory—situations that are dangerous to people and the state itself. Bollywood sheroes exemplify the idea of the hero as a gender-neutral being—someone who fights for the greater good and succeeds.
The Boundary of Laughter
Authors: De Aniket 
Published: August 2023

Abstract
The Boundary of Laughter explores the historical transformation of popular imagination and performance in relation to the emergence of national borders in modern South Asia. Combining archival research with ethnographic fieldwork, it analyses how peasants and laborers presently dwelling on either side of the Indo-Bangladesh border have used the performance tradition known as Gambhira to taunt oppressors, mobilize political sentiment, frame socio-economic demands and respond to seismic political shifts since 1900. Rejecting the idea of ‘communalism’, or the theory of perpetual conflict between the Hindus and Muslims, the book explores Gambhira as a shared social space, constituted through relations across national and religious boundaries. The history of Gambhira shows how the performance existed seamlessly, harnessing both Muslim and Hindu life-worlds and uniting them in the face of colonial oppression. Then came Partition: when, after a troubling process of alignment, a border was forcefully imposed on the region, aiming to place Muslims on one side and Hindus on the other; this ultimately produced two versions of Gambhira, each with their particular postcolonial histories and postcolonial performative forms (one still featuring Shiva, the other taking up the trope of the grandfather/grandson). The shared cultural space of Gambhira, in other words, have not been confined to the territorial boundaries of nation-states. The book uses Gambhira as a lens to examine how performances at South Asia’s borders serve to mediate between larger political-economic changes and smaller, lived worlds of popular expression.
A Preliminary Description of Biblical Verse
Authors: Grosser Emmylou J. 
Published: August 2023

Abstract
Chapter 2 provides a basic introduction to biblical verse-poetry, exploring the following aspects: (1) Biblical poetry is an aural, and not a visual, phenomenon. (2) Biblical poetic lines are not cued by text-internal end-marking; rather, they emerge in patterned or organized relation to each other. (3) Biblical poetic lines emerge in small groupings, often of two or three lines but sometimes larger. (4) Biblical poetry is free-rhythm poetry. (5) Lines of biblical poetry are of variable lengths, but they tend to fall within certain ranges. (6) Biblical poetic lines are structural units of poems built from all aspects of language. These discussions lay the groundwork for a non-parallelistic description of biblical verse-poetry and raise important issues that the book’s cognitive approach accounts for in subsequent chapters.
Symmetry, Balance and Imbalance
Authors: Grosser Emmylou J. 
Published: August 2023

Abstract
Chapter 5 explains the Gestalt principle of symmetry and demonstrates how it functions to create structure and produce effects in various contexts, from line-pairs to larger groupings and stanzas to entire poems. Symmetry is a specific kind of similarity: a similarity both of components and their position within a whole. As a property of wholes, symmetry has the potential to produce perceptual forces that are exploited in the artistry of biblical poems. Another aspect of this artistry is whether symmetry is complete or partial, strong or weak. Because symmetry requires balance but is distinct from it, symmetry provides contexts in which to study balance and imbalance in biblical poetry. Balance and imbalance are felt phenomena that are related to the perceptual tendencies of leveling and sharpening.
“The Stock of a Connoisseur?”
Authors: Harding Graham 
Published: August 2023

Abstract
This chapter examines the uncertain origins and shallow diffusion of connoisseurship among wine drinkers in the late nineteenth and early twentieth century. From the mid-century in Great Britain, a steady flow of wine books began to create a vinous framework that reflected the wide range of wines available in the country’s metropolitan centers. The term connoisseur and the concept of connoisseurship became staple elements in the marketing of wine. However, various factors combined to enable brand owners to exploit a connoisseurship that was based more on a knowledge of brands and acquired or pretended taste for dry champagne than on a depth of expertise or real tasting skill. In ways that prefigured modern marketing practices, the owners of wine brands began to develop and exploit the heritage of the different houses, to link their products to discerning taste and establish their key personnel as taste makers in their own right.