bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant and Anti-Breast Cancer from Uncaria gambir Roxb Leaves: In Silico & In Vitro Study
Authors: Iskandar Dodi , Rollando Rollando , Susana Susana , Amperawati Suharyani , Indrastuti Y Erning , Afthoni Muhammad Hilmi 
Published: January 2025

Uncaria gambir Roxb (URG) is one of the plants from West Kalimantan predicted to contain antioxidant and anti-breast cancer. This study aims to test the antioxidant and anti-breast cancer potential. UGR leaves were extracted by infusion method using water for 15 minutes with 4 repetitions at a temperature 70oC. A thick extract of 96.2351 grams (29.979%) was obtained from a sample weight of 321 grams of dried UGR leaves. In vitro antioxidant assay of the extract was investigated using 2,2-diphenylpicrylhydrazyl (DPPH) with positive control using quercetin and ascorbic acid, and the Ferric Reducing Antioxidant Power (FRAP) method. In silico screening showed that the biological agents in UGR had the potential as TP53 expression enhancer, antioxidant, anticarcinogenic, chemopreventive, and free radical scavenger. The antioxidant bioassay results showed IC50 values of 81.21 μg/mL, 73.39 μg/mL, and 9.17 μg/mL in DPPH for extract samples with positive control quercetin, sample extracts with positive control Vitamin C and Vitamin C with positive control quercetin, respectively. Meanwhile, the antioxidant activity of extract samples with the FRAP method showed value of 66,05 μg/mL. Anticancer bioassay result showed that UGR leaves extract with water solvent had the stron potentgial to inhibit 4T1 cells with IC50 87.72 μg/mL.
In vivo Wound Healing Activity of Tamanu Oil (Calophyllum inophyllum l.) Extracted by Cold-Pressed and Hot-Pressed Methods and Their Fatty Acids Composition
Authors: Rakhmawati Rita , Wahyuni Dinar Sari Cahyaningrum , Ainurofiq Ahmad , Hadi Saptono , Choiri Syaiful , Retnaningtyas Estu , Pratama Tiara Dewi Salindri 
Published: January 2025

Tamanu oil is a promising natural wound healer due to its chemical compounds, particularly fatty acids. Cold-pressed or hot-pressed methods are commonly used to obtain this oil from Calophyllum seed. However, there needs to be research documenting the impact of these two extraction methods on the fatty acid profile and wound healing activity. Therefore, the study aims to characterize the fatty acid profiles of cold-pressed and hot-pressed tamanu oils using Gas Chromatography and evaluate their wound healing activity in vivo. The fatty acid profiles were analyzed using GC, and the wound healing tests were conducted on animal subjects divided into four groups: negative control, positive control (Bioplacenton®), cold-pressed tamanu oil, and hot-pressed tamanu oil. Cold-pressed tamanu oil showed superior fatty acid characteristics with an acid value of 38,71 Mg KOH/g fat and a peroxide value of 3,0095 mEq O2/kg, indicating that oil is stable against oxidation. The length of the wound was observed daily for up to 8 days to assess its effect. The parameters observed were the percentage of wound healing and the total AUC based on the average length of the wound. Cold-pressed tamanu oil demonstrated the highest wound healing efficacy compared to both the positive control and hot-pressed tamanu oils. Both cold (11,67± 0,78) and hot-pressed tamanu oil (11,87 ± 0,61) exhibited significant differences in AUC value compared to the negative control group (13,07 ± 0,38), highlighting the potential of tamanu oil as a wound healing agent.
CONTRACTING BEHAVIOR IN THE GIANT GLADIATOR FROG Boana boans (Hylidae) AND THE EMERALD CRYSTAL FROG Espadarana prosoblepon (Centrolenidae)
Authors: Barría Erick , Barría Maribel , Roy Michael , Fuentes Rogemif 
Published: January 2025

Anurans exhibit several anti-predator behaviors, including thanatosis (also known as tonic immobility) where anurans pretend to be dead, and contracting (or shrinking). In contrast to thanatosis, contracting anurans usually remain with their eyes closed and their limbs contracted close to the body covering vital organs. If one attempts to stretch a limb from a contracted position , it pulls it back to the body after release. Here, we report for the first time, observations of contracting behavior in the Giant gladiator frog (Boana boans), and the Emerald glass frog (Espadarana prosoblepon). These records are important since they contribute towards the understanding of ecology and behavior of these species and anurans generally.
Alimentación emocional e insatisfacción corporal en función del afecto negativo, alimentación no consciente e IMC en hombres y mujeres universitarios
Authors: Pineda-Garcia Gisela , Pérez-Ayala C. , Platas-Acevedo Silvia , Reiván-Ortíz G , Ochoa-Ruíz E , Martínez A.L. , Gómez-Peresmitré G 
Published: January 2025

El objetivo principal de la presente investigación fue probar un modelo que incluye al afecto negativo, la alimentación no consciente, al IMC y al sexo como predictores de la alimentación emocional y la insatisfacción corporal. Se diseñó un estudio con enfoque cuantitativo, transversal, correlacional y se utilizó una muestra no probabilística de 225 hombres y mujeres mexicanos con una edad promedio de 20.84 años (D.E.=2.11). Se aplicó de manera individual con modalidad en línea una batería de pruebas, con adecuadas evidencias de validez y confiabilidad, para medir las variables incluidas en el modelo. Entre los principales resultados, se encontró un modelo con adecuados valores de bondad de ajuste (X2=4.83; p=.565; RMR=.068; NFI=.988; CFI=1.00; RMSEA=.000) que explica casi un 30% de la varianza de la alimentación emocional predicha de manera directa por la alimentación no consciente y el afecto negativo, y un 52% de la insatisfacción con la imagen corporal explicada de manera directa por el sexo, el IMC y la alimentación no consciente. Los hallazgos identifican variables importantes para la salud alimentaria que guían la inclusión de tópicos para la intervención y prevención de trastornos alimentarios y la promoción de una adecuada imagen corporal
Emotion regulation difficulties, body and appearance related self-conscious emotions and eating disorders in a sample of adult women
Authors: Mendia Jara , Pascual Aitziber , Conejero Susana , Mayordomo Sonia , Amutio Alberto 
Published: January 2025

Las variables emocionales juegan un papel fundamental en los Trastornos de la Conducta Alimentaria (TCA). Sin embargo, aún hay ciertas variables que no han recibido suficiente atención. Este estudio transversal tiene como objetivos: 1) analizar el papel de las dificultades en la regulación emocional y las emociones autoconscientes relacionadas con el cuerpo y la apariencia en los TCA; 2) estudiar el poder predictivo de las variables emocionales y 3) explorar las diferencias entre tipos de TCA en las variables mencionadas. Las participantes fueron 767 mujeres de entre 18 y 50 años que tenían un diagnóstico de TCA, estaban en riesgo o eran sanas. El grupo de TCA, seguido por los grupos de riesgo y del sano, puntuó más alto en dificultades de regulación emocional, vergüenza corporal, culpa corporal y más bajo en orgullo corporal hubrístico. Específicamente, las dificultades de regulación emocional y la vergüenza corporal fueron las dos variables que más predijeron los TCA. Asimismo, el grupo con anorexia nerviosa puntuó más alto que el grupo con bulimia nerviosa en desatención emocional y también más alto que el grupo con otros TCA específicos en dificultades de regulación emocional y sus dimensiones "confusión emocional" Y "desatención emocional". Estos hallazgos evidencian el importante papel de las dificultades de regulación emocional y la vergüenza corporal en los trastornos de la conducta alimentaria; desregulación emocional; emociones autoconscientes; imagen corporal.
On the Virtue-theoretic Approach to Argument Appraisal
Authors: McKeon Matthew William 
Published: January 2025

Abstract: Two criticisms of the virtue-theoretic approach to argument appraisal are as follows. First, it is inadequate as argument cogency is conceptually independent of the characteristics of arguers (Bowell and Kingsbury 2013). Second, it is unmotivated since the viability of virtue argumentation theory (VAT) doesn’t require a virtue-theoretic approach to argument appraisal. This deflates the first criticism as an evaluation of VAT (Gascon 2016, Paglieri 2015). I consider each and explain why it is misguided highlighting the connection between the general concept of good argument and associated criteria of goodness, and the connection between good arguments and good arguing.

Résumé: L’approche fondée sur la théorie de la vertu pour l’évaluation des arguments fait l’objet de deux critiques. Premièrement, elle est inadéquate, car la force de l’argument est conceptuellement indépendante des caractéristiques des argumentateurs (Bowell et Kingsbury 2013). Deuxièmement, elle est dénuée de motivation, car la viabilité de la théorie de l’argumentation fondée sur la vertu (AFV) ne nécessite pas une approche fondée sur la théorie de la vertu pour l’évaluation des arguments. Cela dévalorise la première critique en tant qu’évaluation de la AFV (Gascon 2016, Paglieri 2015). J’examine chacune de ces critiques et j’explique pourquoi elles sont erronées en soulignant le lien entre le concept général de bon argument et les critères de bonté qui lui sont associés, et le lien entre les bons arguments et la bonne argumentation.
COUNT DRACULA, LOUIS DE POINTE DU LAC AND EDWARD CULLEN: THE ARCHETYPAL SHIFT OF VAMPIRES FIGURES ACROSS THREE ERAS OF ENGLISH LITERATURE
Authors: Setiyawati Bety 
Published: January 2025

The research aims at finding out the archetype, archetypal shift and the dominant archetype of vampire figures: Count Dracula, Louis de Pointe du Lac and Edward Cullen. The methods used in this research is descriptive qualitative research, used documentation as the technique of collecting data. In this research, the researcher used Archetype theory by Margareth Mark and Carol Pearson and Linda Hutcheon’s theory of shifting to analyze the data. The result of this research showed that there were 137 data in total and are 10 of 12 total archetypes. The analysis on the archetypal shifting classified were; 8 archetypes uses historicizing and 129 dehistoricing. 15 archetyes uses racializing and 122 archetypes uses deracializing. 9 Disembodiments and 3 embodiments. It is found that each figure has a different orientation of characterization depicted its own zeitgeist. Count Dracula a vampire from Victorian era has a clear characterization of a ruler. Contrastingly, Louis de Pointe du Lac of post-modern era has an ambigous personality of being good ‘evil’ and is bond through his past. Differently, A vampire of Contemporary era, Edwrad Cullen, has an obvious characterization as a lover with 2 dominant archetypes takes 66% of the data. Furthermore, the dominant archetype of the data is the Lover which takes 30% of the data as both Louis and Edward created in the era where there is no distinguish point of being good and evil.
Keywords: Vampire, Archetype, Archetypal Shift, Characterization.
The Accounting Supply Chain Challenge: Understanding Its Root Causes and Identifying Factors and Themes for a Plan for Action
Authors: Brink William D. , Eaton Tim V. , Heitger Dan L. , Zhang James 
Published: January 2025

SYNOPSIS
The accounting profession faces a supply chain challenge as fewer college students choose to study accounting. Although its emergence is well documented, limited empirical research examines the underlying factors driving the accounting supply chain challenge. These factors must be clearly understood before effective solutions can be developed and employed. We survey more than 1,400 business school undergraduates (both accounting and nonaccounting) using fixed-response and open-ended questions. We employ factor analysis, logistic regression, and textual analysis to better understand how their perceptions of specific elements of accounting and the profession affect their choice of pursuing an accounting education. We find three factors impacting the choice to pursue an accounting education: (1) perceptions of career opportunities, (2) familiarity with life as an accountant (including work-life balance), and (3) hurdles to the degree/career, particularly the certified public accountant exam requirements. These results have implications for effectively resolving the accounting supply chain challenge.
Data Availability: Data are available upon request.
Evaluation and refinement of thresholds for early migration of total knee replacements as an estimator of late aseptic loosening: an updated systematic review of RSA and survival studies
Authors: Puijk Raymond , Singh Jiwanjot , Puijk Rowan H , Laende Elise K , Plevier José W M , Nolte Peter A , Pijls Bart G C W 
Published: January 2025

Background and purpose: This study updates 2 parallel systematic reviews and meta-analyses from 2012, which established the 1-year radiostereometric (RSA) migration thresholds for tibial components of total knee replacements (TKR) based on the risk of late revision for aseptic loosening from survival studies. The primary aim of this study was to determine the (mis)categorization rate of the 2012 thresholds using the updated review as a validation dataset. Secondary aims were evaluation of 6-month migration, mean continuous (1- to 2-year) migration, and fixation-specific thresholds for tibial component migration.Methods: One review comprised early migration data, measured by maximum total point motion (MTPM), from RSA studies, while the other focused on revision rates for aseptic loosening of tibial components from survival studies. Studies were matched based on prosthesis, fixation (i.e., cemented and uncemented, and uncemented with screw fixation), and insert (PFI). For the primary aim, newly included study group combinations were compared with the 2012 RSA thresholds to determine the (mis)categorization rate. For the secondary aims, new thresholds were determined based on revision rates for any reason in national registries (5-year < 3%, 10-year < 5%, 15-year < 6.5%).Results: After matching studies on PFI, a total of 157 survival and 82 RSA studies were included, comprising 504 study group combinations, 51 different PFIs, and 186,974 TKRs. We found that the 2012 thresholds were valid, with a misclassification rate of 0.5% at 5 and 0.3% at 10 years. Mean continuous migration could not be used to identify safe or unsafe implants. For cemented TKR, the 6-month mean MTPM was acceptable below 0.30 mm and unacceptable above 1.10 mm. For uncemented TKR, it was acceptable below 1.10 mm and unacceptable above 1.55 mm.Conclusion: The updated data reaffirm the 2012 RSA thresholds, confirming their validity in estimating revision risks for tibial component aseptic loosening. The newly proposed fixation-specific 6-month migration thresholds were found to be reliable for early identification of unsafe TKR designs, while 1- to 2-year mean continuous migration data were found not to be reliable for this purpose. These findings support and refine the migration thresholds to improve the evidence-based introduction of new TKR systems.
Olhar e perceber
Authors: Medeiros Adonai da Silva de 
Published: January 2025

O presente texto tem por objetivo compreender o modo como no romance A asa e serpente e no filme Matadouro, ambos de Vicente Franz Cecim (2020; 1975), se dá a realização do homem em meio a um espaço de negação do próprio humano como pro-cura. O diálogo com as obras em estudo tem como ponto de partida as considerações a respeito da “repetição” e “diferença” feitas por Deleuze (1998), para que se compreenda a maneira radical que o romance e o filme as produzem. Isso abriu o texto ao diálogo com Agamben (2009), no que concerne à contemporaneidade e à responsividade do artista em relação a ela, conduzindo para a circum-inscrição e trans-torno, categorias-chave do método de leitura hermenêutica do pesquisador, os quais buscam mostrar, trazendo Rancière (2021) para o fechamento do texto, como as obras se conduzem para uma ficção à margem do nada.
Prevalence of domestic violence among health center users: a retrospective longitudinal analysis
Authors: Fernandez-Mamani Marjorie Cristel , Janampa-Calderon Erika Rosmery , Conde Rodriguez Isaac Alex , Cjuno Julio 
Published: January 2025

Introduction: To determine the prevalence of domestic violence among users of a health center through a retrospective longitudinal analysis by age groups and gender. Methods: This is a retrospective longitudinal study based on data obtained from a health center in Pichari, Cusco, Peru. The sample obtained was 13,040 users of the Comprehensive Health Insurance (SIS) by non-probabilistic sampling. The evaluation was carried out using the Domestic Violence Screening Form (VIF) of the Ministry of Health (MINSA). Results: We found that children and older people have higher survival rates regarding domestic violence, the cumulative risk of domestic violence over time at different stages of development is highest in adolescence, followed by the young stage. Likewise, the cumulative risk is consistently higher for the female gender. Conclusions: Domestic violence presents a higher risk in adolescents, young people, and women. These findings highlight the urgent need to implement concrete measures to address this problem, such as prevention programs, mental health education, and strengthening support and care services for victims and their families.
Konsep Kerakyatan Dalam Filsafat Politik Ibnu Rusyd (Studi Kasus Di Desa Kadibolo Klaten)
Authors: Emy Dwy 
Published: January 2025

Abstract;This research will discuss issues regarding democracy in the view of Ibn Rushd's political philosophy. He is one of the figures who discusses democracy. In this context, Ibnu Rushd puts forward democracy as a concept of independence and freedom. However, according to him, independence and liberty are not without regulatory actions, but freedom and freedom according to religious principles. Ibnu Rushd promoted the concept of democracy, a system which according to him was more in line with the basic laws of human nature. As a realization of the popular ideas he promoted, Ibnu Rushd offered the concept of sovereignty (as-Siyadah) which contained three basic popular principles, namely freedom or independence (al-Huriyyah), equality (al-Musawah), and diversity (pluralism). This research uses quantitative methods with data collection techniques and interviews with several people in Kadibolo village who apply the populist concept based on Ibnu Rushd's thoughts. The research findings are that in Kadibolo village itself, in running its government, it uses popular principles which give its people independence in expressing opinions and also in carrying out activities. However, this does not mean that independence frees them to act as they please, there are still applicable regulations that must be obeyed so that Kadbiolo village remains well organized.Keywords:Democracy; Freedom; Ibn Rushd; Politics. Abstrak;Penelitian ini akan membahas permasalahan mengenai kerakyatan dalam pandangan filsafat politik Ibnu Rusyd. Ia merupakan salah satu tokoh yang membahas tentang kerakyatan. Dalam konteks ini Ibnu Rusyd lebih mengemukkan kerakyatan sebagai konsep kemerdekaan dan kebebasan. Namun kemerdekaan dan kebebasan menurutnya bukanlah tanpa adanya perbuatan yang mengatur, akan tetapi merdeka dan bebas sesuai prinsip agama. Ibnu Rusyd mengusung konsep kerakyatan, sebuah sistem yang menurutnya lebih sesuai dengan hukum-hukum dasar fitriyah manusia. Sebagai realisasi ide kerakyatan yang diusungnya, Ibnu Rusyd menawarkan konsep kedaulatan (as-Siyadah) yang di dalamnya terkandung tiga prinsip dasar kerakyatan, yakni kebebasan atau kemerdekaan (al-Huriyyah), persamaan (al-Musawah), dan keberagaman (pluralisme). Penelitian ini menggunakan metode kuantitatif dengan teknik pengumpulan data dan wawancara beberapa orang di desa Kadibolo yang menerapkan konsep kerakyatan atas pemikiran Ibnu Rusyd. Temuan penelitian bahwa di desa Kadibolo sendiri dalam menjalankan pemerintahannya menggunakan prinsip kerakyatan yang memberikan kemerdekaan masyarakatnya dalam menyampaikan pendapat dan juga dalam berkegiatan. Akan tetapi bukan berarti kemerdekaan tersebut membebaskan mereka untuk bertindak semaunya, tetap ada peraturan yang berlaku untuk ditaati agar desa Kadbiolo tetap tertata dengan baik.Kata Kunci: Ibnu Rusyd; Kerakyatan; Kebebasan; Politik.
Etika Islam: Telaah buku “Antara Al-Ghazali dan Kant: Filsafat Etika Islam”
Authors: Abbas Faiz Musthofa 
Published: January 2025

Abstract;This article is a critical review of a book entitled "Between Al-Ghazali and Kant: The Philosophy of Islamic Ethics" written by M. Amin Abdullah and published by Mizan in 2002. Humans have become more creative and imaginative thanks to science. It is this power of thinking that allows man to discover new disciplines: people depend not only on the success of their predecessors. However, as humans become more creative and their intelligence advances, they sometimes fall into the valley of arrogance. At this time, traditional moral values and standards are increasingly lost. This research method uses qualitative descriptive with M. Amin Abdullah's work Antara Al-Ghazali and Kant: Etka Islam Philosophy as the main source. The results showed that the foundations of the thought systems of two prominent intellectual figures who had a significant influence, namely about ethics. And the similarities between the ethical concepts of al-Ghazali and Immanuel Kant.Keywords:Al-Ghazali; Ethics; Kant. Abstrak;Artikel ini merupakan telaah kritis dari sebuah buku yang berjudul “Antara Al-Ghazali dan Kant: Filsafat Etika Islam” yang ditulis oleh M. Amin Abdullah dan diterbitkan oleh Mizan pada tahun 2002. Manusia telah menjadi lebih kreatif dan imajinatif berkat ilmu pengetahuan. Daya berpikir inilah yang memungkinkan manusia untuk menemukan disiplin ilmu baru: orang tidak hanya bergantung pada kesuksesan para pendahulunya. Namun, ketika manusia menjadi lebih kreatif dan kecerdasannya semakin maju, mereka kadang-kadang jatuh ke lembah kesombongan. Pada saat ini, nilai-nilai moral dan standar tradisional semakin hilang.Metode penelitian ini menggunakan deskriptif kualitatif dengan karya M. Amin Abdullah yaitu Antara Al-Ghazali dan Kant: Filsafat Etka Islam sebagai sumber utamanya. Hasil penelitian menunjukkan bahwa dasar-dasar sistem pemikiran dua tokoh intelektual terkemuka yang memiliki pengaruh yang signifikan, yaitu tentang etika. Dan persamaan antara konsep etika al-Ghazali dan Immanuel Kant adalah keduanya menolak metafisika spekulatif dogmatik, sedangkan etika al-Ghazali bersifat wahyu—berdasarkan al-Quran dan Sunnah—sementara etika Immanuel Kant bersifat rasial—yakni sesuai dengan kehendak manusia.Kata Kunci: Al-Ghazali; Etika; Kant.