bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tonsillectomy Outcomes in Children After Solid‐Organ Transplantation: A 15‐Year Single‐Center Experience
Authors: Hazkani Inbal , Hajnas Natalia , Victor Mitchell , Stein Eli , Richardson Aida , Billings Kathleen R. 
Published: January 2023

AbstractObjectiveSolid‐organ transplantation (SOT) has become the standard of care for children with terminal organ failure. Long‐term immunosuppression has improved survival substantially but is associated with secondary malignancies and impaired wound healing. Our goal was to review the incidence, outcomes, complications, and rate of posttransplant lymphoproliferative disorder on pathologic examination following tonsillectomy/adenotonsillectomy (T/AT) in children after SOT.Study DesignA retrospective cohort study.SettingTertiary care children's hospital.MethodsData were extracted from charts of children with a history of kidney, heart, or liver transplantation, who underwent T/AT between 2006 and 2021.ResultsA total of 110 patients met the inclusion criteria, including 46 hearts, 41 kidneys, 19 livers, and 4 liver‐and‐kidney transplants. The mean age at transplantation was 4.2 years, and the mean transplantation‐to‐T/AT time interval was 28.8 months. The posttransplant lymphoproliferative disorder was diagnosed in 52 (47.3%) patients, and 25% of these had no tonsillar hypertrophy. There was no difference in age at transplantation, organ received, transplantation‐to‐T/AT time interval, immunosuppressive medications, tonsil size, or tonsillar asymmetry between patients diagnosed with the posttransplant lymphoproliferative disorder and patients with benign tonsillar/adenotonsillar hypertrophy. Posttonsillectomy complications were similar between the groups.ConclusionThe incidence of posttransplant lymphoproliferative disorder undergoing tonsillectomy for any indication was 47.3%. There was no association between preoperative signs and symptoms and the histopathological diagnosis of posttransplant lymphoproliferative disorder. Stratification by organ received and immunosuppressive medications did not identify differences among the groups relative to the incidence of posttransplant lymphoproliferative disorder and other postoperative complications.
Detailed analysis of termination kinetics in radical polymerization
Authors: Buback Michael , Russell Gregory T 
Published: January 2023

AbstractStudies into the termination step of radical polymerization have mostly been carried out via chain‐length‐averaged properties. With the advent of pulsed laser polymerization (PLP) induced by single pulses (SPs), the analysis of termination rate coefficients kt has significantly improved. In conjunction with highly time‐resolved near‐infrared (NIR) detection of monomer consumption, SP‐PLP‐NIR allows for the measurement of chain‐length‐averaged termination rate coefficients as a function of temperature, pressure and degree of monomer conversion. With the addition of a suitable reversible addition−fragmentation chain−transfer agent, this technique even allows for the determination of chain‐length‐dependent termination rate coefficients kti,i, where i refers to the chain length of two terminating radicals of identical size. The decay of kti,i with chain length is more pronounced at small radical size below a crossover chain length ic. At larger chain lengths, kti,i decreases to a weaker extent. Thus, the so‐called composite model is perfectly suited for representing kti,i behaviour across the entire chain‐length range. A further clear improvement of kti,i determination is provided by the SP‐PLP‐EPR method, which directly measures the type and concentration of radicals via microsecond time‐resolved electron paramagnetic resonance (EPR) spectroscopy. This EPR‐assisted technique is particularly valuable for polymerizations where secondary radicals undergo backbiting and thus two types of radicals, secondary and tertiary, are simultaneously present, as is the case with acrylic monomers. © 2023 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.
Correlation of thermal, morphological and melt rheological properties of miscible poly(ethylene oxide)/poly(methyl acrylate) and immiscible poly(ethylene oxide)/poly(n‐butyl methacrylate) blends
Authors: Ramli Hairunnisa , Zainal Nurul Fatahah Asyqin , Lai Say Aik , Chan Chin Han 
Published: January 2023

AbstractThis study presents the correlation of thermal, morphological and melt rheological properties of poly(ethylene oxide)/poly(methyl acrylate) (PEO/PMA) blends and PEO/poly(n‐butyl methacrylate) (PEO/PnBMA) blends. The miscibility and correlation of these properties were assessed through thermal analysis such as glass transition temperature (Tg) and apparent melting temperature (Tm), morphological study and melt rheological analysis of the blends. The results show that PEO/PMA blends are miscible as suggested by the number of Tg values that follow the Fox equation and the development of homogeneous mixtures in the molten state (T = 80 °C). On the other hand, PEO/PnBMA blends are immiscible as shown by the constancy of the Tg values of PEO throughout the blend compositions. The immiscibility was confirmed by optical microscopy which shows the matrix‐droplet and co‐continuous morphologies (i.e. heterogeneous mixtures) in the PEO/PnBMA blends at T = 80 °C. Melt rheological properties of the immiscible PEO/PnBMA blends are affected by the blend compositions and show significant deviation from Maxwell behaviour. Conversely, the rheological properties of the miscible PEO/PMA blends show close to Maxwell behaviour. Hence, the correlation of thermal, morphological and melt rheological studies is discussed for both miscible and immiscible PEO/polyacrylate blends. © 2023 Society of Industrial Chemistry.
Rehabilitative exercise scheduling: Effects on balance, functional movement performance, and pain perception in middle‐aged women with knee pain: A randomized controlled trial
Authors: Hosseinzadeh Mahdi , Sardroodian Mahta , Razian Mina , Benoit Colleen , Hoogenboom Barbara J. 
Published: January 2023

AbstractBackgroundThe scheduling of clinical rehabilitative exercise should combine best possible delivery of exercise with the most efficient use of time, facilities, equipment, and personnel. However, it is not clear whether distribution of a fixed amount of exercise volume is more efficient over a longer time period in a week (distributed manner) than over a shorter time period in a week (massed manner).ObjectiveTo evaluate the effects of distributed versus massed within‐ and between‐session exercise scheduling on balance, exercise performance, and pain perception in middle‐aged women with knee pain.ParticipantsThirty‐four middle‐aged female volunteers (mean age ± SD, 56.0 ± 5.2 years old; mean weight ± SD, 66.9 ± 7.6 kg; mean body mass index [BMI] ± SD, 27.7 ± 2.8 kg/m2) were randomly assigned to one of the three groups consisting of Rehabilitative Massed Scheduling (RMS); Rehabilitative Distributed Scheduling (RDS); or Control group (CG).Main Outcome MeasuresIsometric strength, balance, functional movement performance, and pain perception were assessed at baseline (pre), at week 8 (mid), and 1 week after the full 12 weeks (post) of exercise training or no intervention (CG).ResultsSignificant improvements in balance, functional movement performance, and pain perception were found after both RDS and RMS after 8 and 12 weeks compared to the control group (p ˂ .05). Examination of the net changes (% ∆) between RDS and RMS showed a statistically significant difference only in the right 30‐second arm curl records of individuals in the RDS group, which were significantly higher than the RMS group at the post‐test (p ˂ .05).ConclusionRehabilitative training providers are advised to distribute the drills of rehabilitative exercise training within and between the sessions of exercise per week only when a positive Bottom‐Up Rise Strength Transfer effect (BURST) effect of exercise training is needed. Otherwise, if the whole amount of rehabilitative exercise work is identical the benefit of going five versus three times per week to the rehabilitation centers would be similar.
Lethal and sublethal effects of synthetic and bioinsecticides toward the invasive ambrosia beetle Xylosandrus compactus
Authors: Gugliuzzo Antonio , Giuliano Gaetano , Rizzo Roberto , Tropea Garzia Giovanna , Biondi Antonio 
Published: January 2023

AbstractBACKGROUNDExotic ambrosia beetles are emerging widespread pests of several wild and managed trees and shrubs. Xylosandrus compactus (Eichhoff) is one of the most invasive species causing damage to a broad range of host plants. Little information is available on its control, including the impact of insecticides. Bioassays were conducted to evaluate the potential of four bioinsecticides and seven synthetic insecticides in controlling X. compactus. Beetle mortality and sublethal effects on tunneling, cultivation of the mutualist fungus and reproduction were assessed.RESULTSConcentration–mortality curves were determined for all tested insecticides. Lambda‐cyhalothrin was the most toxic insecticide, showing the lowest estimated 90% and 50% lethal concentrations (LC90 and LC50), followed by deltamethrin and thiamethoxam. Acetamiprid caused the highest levels of mortality and brood size reduction under extended laboratory conditions. Moreover, acetamiprid, thiamethoxam and lambda‐cyhalothrin caused the greatest mortality and, together with deltamethrin, strongly affected progeny occurrence inside infested galleries and beetle brood size. Among the bioinsecticides, pyrethrins significantly affected beetle survival under laboratory conditions, but not brood size in extended laboratory bioassays. Some of the tested insecticides had significant lethal and sublethal effects only when beetles were exposed to fresher residues, highlighting differences in toxicity persistence.CONCLUSIONThis study provides first baseline toxicity data for synthetic insecticides and bioinsecticides with different modes of action and origin toward X. compactus, and the first evidence that several insecticides can cause multiple sublethal effects on this pest. These findings can help in building suitable integrated pest management packages against this pest. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
The effect of concentrated pomegranate juice on biomarkers of inflammation, oxidative stress, and sex hormones in overweight and obese women with polycystic ovary syndrome: A randomized controlled trial
Authors: Abedini Maryam , Ramezani‐Jolfaie Nahid , Ghasemi‐Tehrani Hatav , Tarrahi Mohammad Javad , Amani Reza 
Published: January 2023

AbstractPolycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder. Pomegranate juice (PJ) has been known to play anti‐inflammatory and antioxidant roles. However, the effects of PJ on inflammation, oxidative stress, and sex hormones in PCOS patients are very little studied, and thus more studies are needed. This randomized controlled trial enrolled 44 women diagnosed with PCOS according to the Rotterdam criteria, body mass index (BMI) ≥ 25 kg/m2, and aged 18–40 years old. Participants were randomly assigned to take 45 ml/day of concentrated PJ or a control group without intervention. Some biomarkers of sex hormones, inflammation, and oxidative stress were quantified at baseline and after the 8‐week intervention. Compared with the controls, serum testosterone levels were significantly decreased in overweight and obese women with PCOS who supplemented with concentrated PJ (−0.004 ± 0.013 vs. 0.039 ± 0.013, p = .039). However, we did not observe significant differences in luteinizing hormone (LH) and sex hormone‐binding globulin (SHBG) levels and inflammation and oxidative stress factors between the two groups after adjustment for confounding variables. An 8‐week supplementation with concentrated PJ could effectively improve testosterone levels in overweight and obese women with PCOS. This study was registered at www.irct.ir (IRCT20191109045383N1).
Reduced circulating BMP9 and pBMP10 in hospitalized COVID‐19 patients
Authors: Dunmore Benjamin J. , Upton Paul D. , Auckland Kate , Samanta Romit J. ,   CITIID‐NIHR BioResource COVID‐19 Collaboration,   The EpiCov Database, Lyons Paul A. , Smith Kenneth G. C. , Gräf Stefan , Summers Charlotte , Morrell Nicholas W. 
Published: January 2023

AbstractSimilar to other causes of acute respiratory distress syndrome, coronavirus disease 2019 (COVID‐19) is characterized by the aberrant expression of vascular injury biomarkers. We present the first report that circulating plasma bone morphogenetic proteins (BMPs), BMP9 and pBMP10, involved in vascular protection, are reduced in hospitalized patients with COVID‐19.
Folliculocentric Lymphocytic Hypersensitivity Reactions in CLL/SLL Patients: A Unique Clinicopathologic Entity Amongst Non-Specific Hypersensitivity Reactions
Authors: Abbott James , Corean Jessica , Snyder Ashley M. , Florell Scott R. , Miles Rodney , Stephens Deborah , Wada David A. 
Published: January 2023

Abstract

Background
Cutaneous hypersensitivity eruptions in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) are a clinically and histologically heterogeneous group that can either precede, occur with, or follow the development of a hematologic malignancy. Therefore, establishing the diagnosis requires careful clinical and pathologic correlation and an understanding of the broad spectrum of presentations. Data is lacking on the correlation of skin disease with molecular/cytogenetic risk profiling of the tumor.

Objectives
The aims of this study were to characterize the clinical, histological, and genetic aberrations in recurrent cutaneous hypersensitivity reactions in patients with CLL/SLL.

Methods
A single site academic retrospective chart review of medical records, histopathology, molecular and cytogenetic data in CLL/SLL patients who developed biopsy-proven cutaneous hypersensitivity reactions.

Results
Five hundred one new diagnoses of CLL/SLL with 73 patients requiring cutaneous biopsies for skin lesions or rashes were identified. With exclusion criteria, 20 biopsies were identified from 17 patients (mean age, 69.6 years, females = 9) with unexplained cutaneous eruptions. These were commonly pruritic, erythematous papules above the waist. Most biopsies had a prominent superficial, deep dermal eosinophilic infiltrate (85%), with a robust T-cell predominant dermal infiltrate in 40%. Five out of 17 patients (29%) had a predominately folliculocentric CD4+ T-cell infiltrate; all occurring on the head and neck. Overall, the prevalence of cutaneous hypersensitivity eruptions requiring biopsy was 3.4% (n = 17), and the prevalence of folliculocentric CD4+ T-cell infiltrate was 1% (n = 5).

Conclusion
Cutaneous hypersensitivity reactions in CLL/SLL are heterogeneous; however, folliculotropic CD4+ T-cell infiltrates may be seen in a small but distinct clinical subset of patients. Commonly tested cytogenetic aberrations in CLL/SLL do not appear to be correlated with the presence of cutaneous hypersensitivity reactions.
Behavior of lap splices in reinforced concrete beams after bar yielding
Authors: Haavisto Jukka , Alho Heikki , Laaksonen Anssi 
Published: January 2023

AbstractStructural ductility in the case of plastic hinges forming close to a lap splice has been an open issue with the revision process of the next version of Eurocode EC2 concerning reinforced‐concrete structures. This research has provided experimental evidence by the large experimental campaign for the background for revision of the Eurocode EC2. Within this context, 38 specimens were tested in four‐point bending, with the longitudinal bars either lap‐spliced (partly or fully), or un‐spliced (for reference). The tests were carried out involving the variation of the bar diameter (12, 16, 20, and 25 mm), and the lap length (20–60 times the bar diameter). The main result is the sizeable enhancement of the structural ductility brought in by the extension of the lap length in excess of the length required by the yielding of the longitudinal bars. Based on these findings, a preliminary model is developed to describe the bond‐stress profiles in lap splices, after the yielding of the bars.
GPX4 utilization by selenium is required to alleviate cadmium‐induced ferroptosis and pyroptosis in sheep kidney
Authors: Wang Li , Yang Fan , Hu Mingwen , Chen Guiping , Wang Yun , Xue Haotian , Fu Danghua , Bai He , Hu Guoliang , Cao Huabin 
Published: January 2023

AbstractCadmium (Cd), a persistent and harmful heavy metal in the environment, can accumulate in the kidneys and cause nephrotoxicity. Selenium (Se) is a beneficial natural element that alleviates the toxicity of Cd. To ascertain the relationship between the protective mechanism of Se against Cd nephrotoxicity and ferroptosis and pyroptosis, we randomly divided 48 sheep into four groups and treated them with Cd chloride and/or sodium selenite for 50 days. The data confirmed that Cd apparently resulted in impaired kidney histology and function, depletion of GSH and nicotinamide adenine dinucleotide phosphate contents and CAT and SOD activities, elevation of MDA level, as well as the reduction in selenoprotein mRNA (GPX1, GPX4, TXNRD1, SELP) levels and GPX4 protein level and immunofluorescence intensity. Meanwhile, Cd induced ferroptosis by causing iron overload, up‐regulating PTGS2, NCOA4, TFR1, and LC3B mRNA levels and PTGS2 and LC3B‐II/LC3B‐I protein levels, reducing SLC7A11 and FTH1 mRNA and protein levels, and enhancing the immunofluorescence co‐localization of FTH1/LC3B. Moreover, it was also found that Cd triggered pyroptosis, which was evidenced by the increase of NLRP3 immunohistochemical positive signal, GSDMD‐N immunofluorescence intensity, IL‐1β and IL‐18 release and the levels of pyroptosis‐related mRNA (NLRP3, ASC, Caspase‐1, GSDMD, IL‐1β and IL‐18) and proteins (NLRP3, Caspase‐1p20, GSDMD‐N, IL‐1β and IL‐18). Notably, Se increased the expression level of GPX4 and the transcription factors TFAP2c and SP1, and ameliorated Cd‐induced changes in aforementioned factors. In conclusion, GPX4 utilization by Se might be required to alleviate Cd‐induced ferroptosis and pyroptosis in sheep kidney.
Mathematical modeling of graphene–PDMS Maxwell nanofluid flow over a stretching surface: A study on the efficient energy management†
Authors: Mukherjee Satwik , Shit Gopal Chandra , Vajravelu Kuppalapalle 
Published: January 2023

AbstractThis study investigates the unsteady Maxwell nanofluid flow past a stretching surface, embedded in a porous medium, in the presence of magnetic field and thermal radiation effects. Polydimethylsiloxane (PDMS) is considered as a Maxwell base fluid and graphene is taken as nanoparticle to form the nanofluid. It is a well‐reported fact in the literature (Boland et al. Science, 354(2016)1257) that viscous graphene polymers can be used to make sensitive electromechanical sensors, thereby setting the direction and incentive for the study of graphene–PDMS nanofluid. In this paper, we have implemented the Navier's slip boundary condition at the nanofluid‐surface interface. Entropy analysis for the energy efficiency of the system in terms of the Bejan number is carried out extensively. By employing suitable similarity transformations, the set of partial differential equations has been transformed into a set of ordinary differential equations. The transformed equations are solved by the homotopy analysis method (HAM). The nanofluid velocity, temperature, skin‐friction coefficient, and heat transfer rate are analyzed in this paper under several regulatory physical parameters. The findings show that the rise in time relaxation parameter has adverse effects on nanofluid velocity but enhances the entropy generation in the system. The heat transfer rate decreases with an enhancement of the Deborah number but increases with a rise in the nanoparticle volume fraction. The Bejan number shows increasing trend with an enhancement of unsteady parameter, nanoparticle volume fraction, and porous permeability parameter. This study bears the potential application in powder technology, plastic extrusion process, as well as in bio‐engineering.
Positional cloning identified HvTUBULIN8 as the candidate gene for round lateral spikelet (RLS) in barley (Hordeum vulgare L.)
Authors: Qin Dandan , Liu Gang , Liu Rui , Wang Chunchao , Xu Fuchao , Xu Qing , Ling Yu , Dong Guoqing , Peng Yanchun , Ge Shuangtao , Guo Ganggang , Dong Jing , Li Chengdao 
Published: January 2023

Abstract
Key message
Map-based cloning, subcellular localization, virus-induced-gene-silencing and transcriptomic analysis reveal HvTUB8 as a candidate gene with pleiotropic effects on barley spike and leaf development via ethylene and chlorophyll metabolism.

Abstract
Barley lateral spikelet morphology and grain shape play key roles in grain physical quality and yield. Several genes and QTLs for these traits have been cloned or fine mapped previously. Here, we report the phenotypic and genotypic analysis of a barley mutant with round lateral spikelet (rls) from cv. Edamai 934. rls had round lateral spikelet, short but round grain, shortened awn, thick glume and dark green leaves. Histocytologic and ultrastructural analysis revealed that the difference of grain shape of rls was caused by change of cell arrangement in glume, and the dark leaf color resulted from enlarged chloroplast. HvTUBULIN8 (HvTUB8) was identified as the candidate gene for rls by combination of RNA-Seq, map-based-cloning, virus-induced-gene-silencing (VIGS) and protein subcellular location. A single G-A substitution at the third exon of HvTUB8 resulted in change of Cysteine 354 to tyrosine. Furthermore, the mutant isoform Hvtub8 could be detected in both nucleus and cytoplasm, whereas the wild-type protein was only in cytoplasm and granular organelles of wheat protoplasts. Being consistent with the rare phenotype, the “A” allele of HvTUB8 was only detected in rls, but not in a worldwide barley germplasm panel with 400 accessions. VIGS confirmed that HvTUB8 was essential to maintain spike integrity. RNA-Seq results suggested that HvTUB8 may control spike morphogenesis via ethylene homeostasis and signaling, and control leaf color through chlorophyll metabolism. Collectively, our results support HvTUB8 as a candidate gene for barley spike and leaf morphology and provide insight of a novel mechanism of it in barley development.
Estimating the set of bifurcation values of a smooth function
Authors: Klepczarek Michał 
Published: January 2023

AbstractWe introduce the framework for finding out conditions that imply that $$y\in {\mathbb {R}}$$

y
∈
R

is a typical value of a smooth function f defined on an open subset of $${\mathbb {R}}^n$$

R

n

. We adopt this framework to obtain some currently known conditions for estimating the set of bifurcation values. Additionally, we give two new such conditions. Moreover, we show that the trivialization of f in a neighbourhood U of $$f^{-1}(y)$$

f

-
1

(
y
)

can always be obtained by integrating its gradient with respect to some metric on U.