bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bladder Paraganglioma Associated With Succinate Dehydrogenase A Mutation Presenting as Pelvic Pain
Authors: Hehar Gurbir , Rahmon Dalia , Banka Ajaz 
Published: January 2023

Abstract
A 21-year-old female presented to the hospital with acute onset left pelvic pain that began while urinating. Ultrasound of the pelvis revealed a 1.7 cm structure within the bladder wall. Follow-up imaging with magnetic resonance imaging confirmed a 1.9 cm mass in the urinary bladder wall. Cystoscopy with transurethral resection was performed. Histopathology of the obtained tissue confirmed the diagnosis of paraganglioma. Laboratory evaluation revealed evidence of catecholamine excess with elevated urine norepinephrine, urine normetanephrine, and plasma free normetanephrine. Functional imaging with Ga-DOTATATE positron emission tomography-computed tomography (PET-CT) revealed increased uptake in the region of the known mass without findings of metastasis. Genetic testing revealed succinate dehydrogenase A mutation, consistent with paraganglioma syndrome 5. The patient was treated with alpha-adrenergic blockade prior to partial cystectomy. Urinary bladder paraganglioma is a rare entity. The diagnosis requires a high index of clinical suspicion due to variable presentation. Hypertension and other signs of catecholamine excess, especially in relation to micturition, are important clues. Despite evidence of catecholamine excess in most patients with bladder paraganglioma, the majority are diagnosed after biopsy, indicating a need for improved diagnostic strategies in this patient population. Early diagnosis and treatment are essential to prevent potentially lethal cardiac complications and tumor metastasis.
COMPUTER SIMULATOR GAME IN YOUTH CULTURE
Authors: Kudryashova Elizaveta M. , Lyubimtseva Ekaterina M. , Yushchenko Vera M. , Barinova Sof’ya G. 
Published: January 2023

Purpose. The purpose of the study is to determine the place, meaning, perspectives of the computer game simulator “The Sims” in the cultural space of youth, supplemented by a new digital environment, and to establish the reasons for its 20-year success.
Methodology. The main theoretical and methodological approaches to the review of a computer game are systemic and complex. The specifics of the study revealed the need for a cause-and-effect analysis of the studied phenomenon.
Results. The sociocultural aspect of young people involvement in the computer game “The Sims” is primary. The esthetic aspect (graphics, technical characteristics, which have been getting better and worse over for 20 years) is secondary. Namely the experience of attempt “life situations”, building own world, relationships, yourself attracts young players. Gamers see the game as a unique philosophy and values, that they share with the creators of the game, which is a prerequisite for the emergence of a digital cultural community based on a particular game. Given the wide range of players and interest in computer games, it is important to study them in a cultural context, since psychological and other characteristics go by the wayside (a variety of people play computer games, which is not associated with any personal characteristics, for example, introversion, self-doubt).
Practical implications. The results of the study can be applied in philosophy, cultural studies and pedagogy.
АРХЕТИПИЧЕСКИЙ ОБРАЗ МАТЕРИ В ЖИВОПИСИ Ш. ШАМУРЗАЕВА
Authors: Khamzatova Zarema R. 
Published: January 2023

Цель – определение философско-аксиологических оснований национального изобразительного искусства второй половины XX века посредством анализа творчества одного из первых профессиональных чеченских советских художников Шамиля Алиевича Шамурзаева.
Методология строится на синтезе междисциплинарных и историко-искусствоведческих подходов. Метод иконологии актуален при дешифровке художественных значений образов в контексте архетипов традиционной духовной культуры в творчестве Ш. Шамурзаева. Философско-культурологический метод в сочетании с культурно-историческим позволил показать влияние реалий общественной, социальной, культурной жизни изучаемой эпохи на выбор сюжетов, художественный язык советского чеченского художника.
Результаты. Индивидуально найденные характеристики обуславливают новизну работы. Советское искусство периода активной художественной деятельности Ш. Шамурзаева характеризуется противопоставлением наследия социалистического реализма и искусства оттепели с мифологизированным ожиданием весны, надежды, открытости миру и этики долга и ответственности сурового стиля.
Анализируются произведения разных периодов творчества Ш. Шамурзаева в которых прослеживается аксиология концепта матери, как одного из фундаментальных смыслообразующих ценностей традиционной чеченской культуры.
Область применения результатов. Если культурный релятивизм определяет разновекторную аксиологическую направленность советского искусства вообще, то в национальных окраинах он сопряжен с мировоззренческим национальным наследием. Такое расширение представлений о национальном искусстве имеет значение с точки зрения истории развития советского искусства в национальных окраинах, делая работу востребованной в различных сферах гуманитарного знания.
HEROIC MYTH IN THE WORKS OF SOVIET CHILDREN’S WRITERS
Authors: Panova Elena P. , Saenko Natalya R. 
Published: January 2023

Purpose. The purpose of this study is to identify and further analyze the phenomenology and content-plot side of Soviet neomythology, embodying the archetype of the hero-victim in the textual materials of artistic poetry and prose for children, as well as the means used for this embodiment.
Methodology. The method or methodology of doing the work. In the course of the work, the method of text analysis, content analysis, cross-factor analysis of the material of a number of sources was used according to parameters that have their own content, significant for achieving the goal stated in the study.
Results. The article analyzes the structure and pragmatics of the ideologically oriented Soviet neo-myth. Particular attention was paid to the analysis of such categories as the sacralization and instrumentalization of the created mythological material, the inherent characterological features and features of the created image, which make it possible to characterize the characters created by different children’s writers as fighters, as heroes, as sacred victims. According to the results of the study, the features of the heroic character of childhood, his sacrifice and immortality, formed by the myth in the mass public perception, are identified and analyzed. In conclusion, a number of pragmatic aspects of operating the cultural image of a child-hero and a child-victim from the side of ideology, patriotic education with the help of emotions and moods of society are considered.
Practical implications. The results of the study can be applied in the field of cultural studies, philosophy of culture, philosophy of literature to analyze effective and ineffective in the field of educating an active citizen and patriot through artistic techniques. The results of the analysis are acutely relevant, since modern Russian culture needs effective tools for civic and patriotic education.
AESTHETIC EXISTENCE AS THE BASIS OF MODERN CULTURE OF EMOTIONS
Authors: Lobanova Yuliya V. 
Published: January 2023

Purpose. The aim of the study is to determine the features of the historical genesis of aesthetic forms of interaction between individuals in the conditions of modern culture, providing significant characteristics of human existence, implemented in interactive and communicative modes of his emotionally colored interaction with the world.
Methodology. The methods of textual and content analysis of the material of the primary sources of classical and modern authors, as well as the analysis of some components of the aesthetic matrix of modern culture in terms of parameters that are essential for achieving the stated goal are used. The author turns to the socio-philosophical and sociopsychological analysis of the emotionalization of modern culture. The article uses historical-philosophical and philosophical-anthropological methods for an analytical description of the process of compensatory aestheticization.
Results. In this article, based on the analysis of program works of the founder of existential philosophy S. Kierkegaard, the subsequent entry into the space of modern communication culture was carried out in order to conduct a further comparative study of Kierkegaard’s main ideas, and their modern embodiment in the form of emotional existence of a communicative-collective nature. Particular attention is paid in this regard to the meaningful development of the ideas of the Danish thinker by the existentialist philosophers of the last century M. Heidegger and J. Habermas, as well as the most influential researchers in the philosophy of modern sociocultural genesis B. Huebner, J. Ransier. In conclusion, a number of the most significant changes in modern communication culture, inspired by the turn of the interest of a person and society in the emotional side of their own being, are examined, and their specific phenomenology is considered in relation to the reasons that caused these changes. The author enters into a discussion with A. Reckwitz about the society of singularities, putting forward the concept of a society of collective, stereotyped experience.
Practical implications. The results of the study can be applied in the field of cultural studies, philosophy of culture, psychology.
THE EFFECTS OF THE INTRODUCTION OF THE TV SCREEN IN EVERYDAY AND PERSONAL SPACE
Authors: Grigoryev Sergey L. 
Published: January 2023

Purpose. The purpose of this study is to identify and fix the nature of the changes associated with the emergence and subsequent change in the role of television within the sociocultural universe of modern man. An analysis of its features, characteristics and factors that are currently causing the most significant changes within this sphere, which actually creates its own “second reality”.
Methodology. The study used the historical method, analysis of textual materials, as well as content analysis and cross-factor analysis of sources in terms of parameters that have content, the study of which was important to achieve the intended goal. To consider this problem, the author turns to the socio-philosophical and anthropological analysis of the role of the screen in modern culture. The article uses comparative analysis, historical-philosophical and anthropological methods.
Results. This article explores the historical socio-cultural genesis of television as a mass media, from the moment the first television devices were created to the present. A number of modern views on the peculiarities of the influence of the fact of the appearance of television on the perception and consciousness of the viewer in the process of informing him through the television screen are consistently considered, and their comparison is made. Particular attention is paid to the analysis of the factors of influence of television on the foundations of modern mass culture formed by it. According to the results of the study, the origins and reasons for the gradual transformation of the main function of television from mass information to equally massive manipulation are identified and analyzed, within which the basic types of social impact and the formation of a different, television reality are identified. In conclusion, the processes of mediatization of the social existence of an individual, as well as the crisis of his cultural identity, are considered separately.
INTERETHNIC RELATIONS IN THE TRANS-BAIKAL TERRITORY: CURRENT STATE AND DEVELOPMENTAL TRENDS (BASED ON THE MATERIALS OF SOCIOLOGICAL STUDY)
Authors: Lavrikova Victoria N. 
Published: January 2023

Purpose. The article deals with the issues of interethnic relations as the object of sociological analysis, it also shows the specifics of the study of this type of relations in sociology. The author aims at sociological analysis of interethnic relations in such a multiethnic region as the Trans-Baikal Territory which is characterized by the heterogeneity of its national composition.
Method or methodology of study. The research is based on a comparative method and on such sociological methods as online and expert survey.
Results. The results of the research are based on the materials of sociological study that shows the current state of interethnic relations in the considered subject of the Russian Federation. The author determines the attitude of residents of the Trans-Baikal Territory to a particular nationality, identifies the causes and prospects of interethnic conflicts in the Trans-Baikal Territory, presents an expert assessment of relations between various diasporas of the Trans-Baikal Territory, their individual representatives and the authorities. The author concludes that the Trans-Baikal Territory being a multiethnic subject of the Russian Federation is characterized by relative stability of relations between representatives of different nationalities. However, great attention should be paid by the regional authorities to the fact that interethnic conflicts are not excluded on the territory of the region.
Scope of the results. The study results can be applied in the management field of international and interethnic relations on the territory of the Trans-Baikal Territory.
The perspectives of pharmacological correction of depressive disorders and cognitive deficit as post-traumatic epilepsy leading syndromes
Authors: Ostapenko I. 
Published: January 2023

Traumatic brain injury is the leading cause of symptomatic epilepsy at a young age. Post-traumatic epilepsy (PTE) is the main factor in disabling patients of working age and impairs the quality of life. Comorbid pathology in the form of psychoemotional and cognitive disorders essentially has a single pathogenetic mechanism on the part of traumatic brain disease. There are problems with differential diagnosis between comorbid and direct manifestations of PTE. The above dictates the need to develop modern complex approaches to the treatment of PTE and correction of accompanying and comorbid pathological conditions. Author tries to develop new pathogenetically adequate approaches to the treatment of PTE with correction of the psycho-emotional sphere and cognitive deficit. 44 patients with PTE were examined. The average period of its formation reached 10.3±4.2 years, and the frequency of attacks – 2.4±0.9 per month. Focal attacks prevailed (61.4%). In addition to standard long-term anticonvulsant monotherapy, the main group (32 patients) was prescribed ethylmethylhydroxyperidine succinate and vortioxetine. The control group (12 patients) received only anticonvulsant therapy.
When using the proposed complex treatment, the number of people with depression decreased from 25 (56.8%) to 10 (22.7%) cases, that is, by 2.5 times (P <0.05). In the main group, from 59.4% to 21.9%, i.e. 2.7 times (Р<0.05). In the control – from 50.0% to 41.7% (Р>0.05). 37.5% registered positive dynamics in relation to pathological activity on the electroencephalogram. According to the Luria A. R. test, the average values of the obtained data at all stages of word presentation were probably higher than at the beginning of the study. Indicators of long-term memory changed similarly.
Thus, the proposed treatment approach has a beneficial effect on the main pathogenetic links of the development of PTE, its course and corrects cognitive deficits, psychoemotional layers, which are comorbid conditions.
Regulating Probabilistic Selling of Counterfeits
Authors: Gao Yuetao , Wu Yue 
Published: January 2023

Counterfeits are available across many marketplaces. In emerging markets, in particular, consumers often observe a mix of counterfeits and authentic products sold by retailers. It is difficult for some consumers to distinguish between the two types of products. From these consumers’ perspective, the products can be considered as probabilistic goods, and we term retailers’ strategies probabilistic selling of counterfeits. Retailers who sell counterfeits are subject to a penalty by regulation. We develop a game-theoretical model to study this dishonest strategy under regulation. Our model offers the following insights. First, a higher penalty for selling counterfeits can lead to a smaller proportion of authentic products in the market. This finding is driven by a manufacturer’s strategic response: knowing that the penalty becomes higher, the manufacturer has greater incentives to raise the wholesale price of its authentic products. From the retailers’ point of view, this elevated procurement cost can, in turn, encourage them to lower the probability of their products being authentic. Second, manufacturer profit increases with the penalty, whereas retailer profit, consumer surplus, and social welfare do not, in general, exhibit a monotonic relationship with the penalty. This paper was accepted by Dmitri Kuksov, marketing. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4607 .
Optimal Sequencing in Single-Player Games
Authors: Li Yifu , Ryan Christopher Thomas , Sheng Lifei 
Published: January 2023

An important problem in single-player video game design is how to sequence game elements within a level (or “chunk”) of the game. Each element has two critical features: a reward (e.g., earning an item or being able to watch a cinematic) and a degree of difficulty (e.g., how much energy or focus is needed to interact with the game element). The latter property is a distinctive feature in video games. Unlike passive services (like a trip to the spa) or passive entertainment (like watching sports or movies), video games often require concerted effort to consume. We study how to sequence game elements to maximize overall experienced utility subject to the dynamics of adaptation to rewards and difficulty and memory decay. We find that the optimal design depends on the relationship between rewards and difficulty, leading to qualitatively different designs. For example, when the proportion of reward-to-difficulty is high, the optimal design mimics that of more passive experiences. By contrast, the optimal design of games with low reward-to-difficulty ratios resembles work-out routines with “warm-ups” and “cool-downs.” Intermediate cases may follow the classical “mini-boss, end-boss” design where difficulty has two peaks. Numerical results reveal optimal designs with “waves” of reward and difficulty with multiple peaks. Level designs with multiple peaks of difficulty are ubiquitous in video games. In summary, this paper provides practical guidance to game designers on how to match the design of single-player games to the relationship between reward and difficulty inherent in their game’s mechanics. Our model also has implications for other interactive services that share similarities with games, such as summer camps for children. This paper was accepted by Jeannette Song, operations management. Funding: This work was supported by the National Natural Science Foundation of China [Project 72201210] and Natural Sciences and Engineering Research Council of Canada [Grant RGPIN-2020-06488]. Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2022.4665 .
CVVHD results in longer filter life than pre-filter CVVH: Results of a quasi-randomized clinical trial
Authors: Mann Lewis , Ten Eyck Patrick , Wu Chaorong , Story Maria , Jenigiri Sree , Patel Jayesh , Honkanen Iiro , O’Connor Kandi , Tener Janis , Sambharia Meenakshi , Fraer Mony , Nourredine Lama , Somers Douglas , Nizar Jonathan , Antes Lisa , Kuppachi Sarat , Swee Melissa , Kuo Elizabeth , Huang Chou-Long , Jalal Diana I. , Griffin Benjamin R. 
Published: January 2023

Background
Filter clotting is a major issue in continuous kidney replacement therapy (CKRT) that interrupts treatment, reduces delivered effluent dose, and increases cost of care. While a number of variables are involved in filter life, treatment modality is an understudied factor. We hypothesized that filters in pre-filter continuous venovenous hemofiltration (CVVH) would have shorter lifespans than in continuous venovenous hemodialysis (CVVHD).

Methods
This was a single center, pragmatic, unblinded, quasi-randomized cluster trial conducted in critically ill adult patients with severe acute kidney injury (AKI) at the University of Iowa Hospitals and Clinics (UIHC) between March 2020 and December 2020. Patients were quasi-randomized by time block to receive pre-filter CVVH (convection) or CVVHD (diffusion). The primary outcome was filter life, and secondary outcomes were number of filters used, number of filters reaching 72 hours, and in-hospital mortality.

Results
In the intention-to-treat analysis, filter life in pre-filter CVVH was 79% of that observed in CVVHD (mean ratio 0.79, 95% CI 0.65–0.97, p = 0.02). Median filter life (with interquartile range) in pre-filter CVVH was 21.8 (11.4–45.3) and was 26.6 (13.0–63.5) for CVVHD. In addition, 11.8% of filters in pre-filter CVVH were active for >72 hours, versus 21.2% in the CVVHD group. Finally, filter clotting accounted for the loss of 26.7% of filters in the CVVH group compared to 17.5% in the CVVHD group. There were no differences in overall numbers of filters used or mortality between groups.

Conclusions
Among critically patients with severe AKI requiring CKRT, use of pre-filter CVVH resulted in significantly shorter filter life compared to CVVHD.

Trial registration
ClinicalTrials.gov, NCT04762524. Registered 02/21/21—Retroactively registered, https://clinicaltrials.gov/ct2/show/NCT04762524?cond=The+Impact+of+CRRT+Modality+on+Filter+Life&draw=2&rank=1.
Thresholds of liminality: discourse and embodiment from separation to consummation among Guatemalan Maya youth workers in Los Angeles
Authors: O’Connor Brendan H. , Canizales Stephanie L. 
Published: January 2023

AbstractThis paper brings contemporary scholarship on youth migration, Indigeneity, race, and language into conversation with formative work on liminality and rites of passage. Drawing on six years’ worth of participant observation and interviews with L1 Maya (primarily K’iche’) speaking Guatemalan youth workers in Los Angeles, we theorize the transformations that characterize urban immigrant life for Indigenous Latinxs in the contemporary United States as a passage through the liminal state from separation to consummation. We first analyze participants’ language behavior during the separation phase following migration, when youth sought to defend themselves from anti-Indigenous harm and discrimination through discourse practices such as cloaking or denying Maya proficiency, claiming to be Mexican or non-Indigenous Guatemalan, or avoiding speaking Spanish or K’iche’ in public. Participants also employed techniques of bodily concealment that were believed to make them less racially identifiable in physical terms. As time went on, youth felt less of a need to defend themselves from stigmas attached to Indigeneity and Guatemalan identity and began to consider possibilities for expressing ethnic and linguistic pride in communal settings. This reflection was enabled by youth’s growing embeddedness in Los Angeles’s multicultural society along with coethnic small group settings that valorized Indigeneity and invited youth to compare their trajectories to those of other immigrant groups. We acknowledge the distinctive challenges that Indigenous youth encounter as immigrants to the US. However, our findings point beyond Indigenous Latinxs’ post-migration experiences of shame, fear, and discrimination to possibilities for language maintenance and cultural pride in the context of long-term sobrevivencia, or survival, in diaspora.