bluuebunny/crossref_metadata_2025_split huggingface dataset:
In the jungle, the mighty jungle, the zebras are teal tonight: investigating the organizational forms of Generation Z-driven Italian start-ups
Authors: de Gennaro Davide , Mormile Simona , Piscopo Gabriella , Adinolfi Paola 
Published: June 2023

PurposeIn light of the new way of interpreting work spearheaded by Generation Z, the objectives of this study are to investigate (1) whether young entrepreneurs identify their start-ups with “zebras” – that is, as a concrete response to the evanescence and fantasy of “unicorns” based on the simultaneous pursuit of profit and social value, mutualism and resilience – and (2) whether they adopt a “teal” organizational configuration – that is, one characterized by evolutionary purpose, self-management and wholeness.Design/methodology/approachThrough a qualitative approach with 41 interviews, this study focuses on start-uppers and companies that are particularly innovative and promising in the Italian context, as selected by Forbes magazine in its ranking of the brightest entrepreneurs, leaders and stars under 30.FindingsThe results suggest that young entrepreneurs recognize the importance of the common themes of the zebra movement and therefore identify their startups with zebras. More specifically, Generation Z entrepreneurs: (1) pursue a dual (economic and social) purpose, (2) are mutualistic and (3) build their organizations with resilience and capital efficiency. In addition, the interviews show that the organizational approach taken follows the paradigm of teal organizations, particularly in terms of evolutionary purpose, distributed leadership and decision-making power, and employee wholeness and empowerment.Originality/valueThis is the first study to analyze the evolutionary trends of animal entrepreneurial “species” led by Generation Z entrepreneurs and organized on the basis of the teal paradigm.
A Sami land‐claims settlement? Assessing Norway's Finnmark Act in a comparative perspective
Authors: Spitzer Aaron John , Selle Per 
Published: June 2023

AbstractThe Sami, the Indigenous peoples of Fennoscandia, assert ownership‐, use‐, and management‐rights to their traditional lands. Norway's 2005 Finnmark Act is the only legislation so far to broadly respond to those assertions. How to interpret the act has long been contested, and is now the subject of a legal case before Norway's Supreme Court. Despite parallels between the land‐rights assertions of Sami and those of Indigenous peoples elsewhere, and despite abundant legislation responding to Indigenous land‐rights assertions elsewhere, the Finnmark Act has seldom been analyzed comparatively. In this article, we study the act against the backdrop of Indigenous land‐claims settlements in Canada—the state where such legislation is most institutionalized. We find the Finnmark Act features many of the same institutional and procedural elements as Canadian settlements. However, we also find that in Norway those elements have been legally integrated, and practically implemented, in a different and less coherent way, rendering the act dysfunctional. We conclude by drawing lessons from the Canadian example to prescribe adjustments to the understanding and ongoing implementation of the Finnmark Act, to potentially put the accommodation of Sami land‐rights on a smoother path.
Identification of potent target and its mechanism of action of Tripterygium wilfordii Hook F in the treatment of lupus nephritis
Authors: Cai Bin , Lu Hongjuan , Ye Qianyi , Xiao Qingqing , Wu Xin , Xu Huji 
Published: June 2023

AbstractAimThe Chinese anti‐rheumatic herbal remedy Tripterygium wilfordii Hook F (TWHF) has been widely shown to be effective in treating lupus nephritis (LN), but the therapeutic targets and mechanisms of action are still unclear. In this study, we aimed to combine mRNA expression profile analysis and network pharmacology analysis to screen the pathogenic genes and pathways involved in LN and to explore the potential targets of TWHF in the treatment of LN.MethodsThe mRNA expression profiles of LN patients were used to screen differentially expressed genes (DEGs) and to predict associated pathogenic pathways and networks via the Ingenuity Pathway Analysis database. Through molecular docking, we predicted the mechanism by which TWHF interacts with candidate targets.ResultsA total of 351 DEGs were screened from the glomeruli of LN patients and were mainly concentrated in the role of pattern recognition receptors in the recognition of bacteria and viruses and interferon signaling pathways. A total of 130 DEGs were screened from the tubulointerstitium of LN patients, which were concentrated in the interferon signaling pathway. TWHF might be effective in treating LN by hydrogen bonding to regulate the functions of 24 DEGs (including HMOX1, ALB, and CASP1), which are mainly concentrated in the B‐cell signaling pathway.ConclusionThe mRNA expression profile of renal tissue from LN patients revealed a large number of DEGs. TWHF has been shown to interact with the DEGs (including HMOX1, ALB and CASP1) through hydrogen bonding to treat LN.
Accounting for waste: Waste reporting in Australian metals and mining companies
Authors: Ha Le Thuy Duong , Mansi Mansi 
Published: June 2023

AbstractAustralian metals and mining companies are the focus of this study because mining activities are a significant source of waste products on a global scale, and to date, there has been no systematic review or comparison of how these companies report their waste management practices. Recognising that waste management is an important issue with future implications, this study is guided by one primary research question: What is the nature and extent of waste management disclosures by the top metals and mining companies in Australia?
Comments of the AFAANZ Auditing and Assurance Standards Committee on Proposed International Standard on Auditing 500 (Revised) Audit Evidence
Authors: Fu Yi (Dale) , Harding Noel , Hay David C. , Khan Mohammad Jahanzeb , Scott Tom , Singh Harj , Stepankova Sarka , Sultana Nigar 
Published: June 2023

AbstractThe International Auditing and Assurance Standards Board (IAASB) issued for public comment Proposed International Standard on Auditing 500 (Revised) Audit Evidence. The Australian Auditing and Assurance Standards Board (AUASB) and New Zealand Auditing and Assurance Standards Board (NZAuASB) also called for comments. The Auditing and Assurance Standards Committee of AFAANZ prepared a submission, based on the findings reported in extant research, responding to a number of the questions asked by the IAASB (and AUASB/NZAuASB). This technical note presents the formal submission made to the IAASB.
Extracellular matrix‐related and serine protease proteins in the amniotic fluid of women with early preterm labor: Association with spontaneous preterm birth, intra‐amniotic inflammation, and microbial invasion of the amniotic cavity
Authors: Lee Kyong‐No , Park Kyo Hoon , Ahn Kwanghee , Im Eun Mi , Oh Eunji , Cho Iseop 
Published: June 2023

AbstractProblemWe aimed to determine whether altered levels of various extracellular matrix (ECM)‐related and serine protease proteins in the amniotic fluid (AF) are associated with imminent spontaneous preterm birth (SPTB; ≤7 days) and intra‐amniotic inflammation and/or microbial invasion of the amniotic cavity (IAI/MIAC) in women with early preterm labor (PTL).Method of studyThis retrospective cohort study included 252 women with singleton pregnancies undergoing transabdominal amniocentesis who demonstrated PTL (24–31 weeks). The AF was cultured for microorganism detection to characterize MIAC. IL‐6 concentrations were determined in the AF samples to identify IAI (≥2.6 ng/mL). The following mediators were measured in the AF samples using ELISA: kallistatin, lumican, MMP‐2, SPARC, TGFBI, and uPA.ResultsKallistatin, MMP‐2, TGFBI, and uPA levels were significantly higher and SPARC and lumican levels were significantly lower in the AF of women who spontaneously delivered within 7 days than in the AF of those who delivered after 7 days; the levels of the first five mediators were independent of baseline clinical variables. In the multivariate analysis, elevated levels of kallistatin, MMP‐2, TGFBI, and uPA and low levels of lumican and SPARC in the AF were significantly associated with IAI/MIAC and MIAC, even after adjusting for the gestational age at sampling. The areas under the curves of the aforementioned biomarkers ranged from 0.58 to 0.87 for the diagnoses of each of the corresponding endpoints.ConclusionECM‐related (SPARC, TGFBI, lumican, and MMP‐2) and serine protease (kallistatin and uPA) proteins in the AF are involved in preterm parturition and regulation of intra‐amniotic inflammatory/infectious responses in PTL.
Water column contributions to coral reef productivity: overcoming challenges of context dependence
Authors: Shakya Anjali W. , Allgeier Jacob E. 
Published: June 2023

ABSTRACTCoral reefs are declining at an unprecedented rate. Effective management and conservation initiatives necessitate improved understanding of the drivers of production because the high rates found in these ecosystems are the foundation of the many services they provide. The water column is the nexus of coral reef ecosystem dynamics, and functions as the interface through which essentially all energy and nutrients are transferred to fuel both new and recycled production. Substantial research has described many aspects of water column dynamics, often focusing on specific components because water column dynamics are highly spatially and temporally context dependent. Although necessary, a cost of this approach is that these dynamics are often not well linked to the broader ecosystem or across systems. To help overcome the challenge of context dependence, we provide a comprehensive review of this literature, and synthesise it through the perspective of ecosystem ecology. Specifically, we provide a framework to organise the drivers of temporal and spatial variation in production dynamics, structured around five primary state factors. These state factors are used to deconstruct the environmental contexts in which three water column sub‐food webs mediate ‘new’ and ‘recycled’ production. We then highlight critical pathways by which global change drivers are altering coral reefs via the water column. We end by discussing four key knowledge gaps hindering understanding of the role of the water column for mediating coral reef production, and how overcoming these could improve conservation and management strategies. Throughout, we identify areas of extensive research and those where studies remain lacking and provide a database of 84 published studies. Improved integration of water column dynamics into models of coral reef ecosystem function is imperative to achieve the understanding of ecosystem production necessary to develop effective conservation and management strategies needed to stem global coral loss.
A homozygous founder variant in PDE2A causes paroxysmal dyskinesia with intellectual disability
Authors: Yousaf Hammad , Rehmat Shagufta , Jameel Muhammad , Ibrahim Rabab , Hashmi Sohana Nadeem , Makhdoom Ehtisham Ul Haq , Iwaszkiewicz Justyna , Saadi Saadia Maryam , Tariq Muhammad , Baig Shahid M. , Toft Mathias , Fatima Ambrin , Iqbal Zafar 
Published: June 2023

AbstractIntellectual developmental disorder with paroxysmal dyskinesia or seizures (IDDPADS, OMIM#619150) is an ultra‐rare childhood‐onset autosomal recessive movement disorder manifesting paroxysmal dyskinesia, global developmental delay, impaired cognition, progressive psychomotor deterioration and/or drug‐refractory seizures. We investigated three consanguineous Pakistani families with six affected individuals presenting overlapping phenotypes partially consistent with the reported characteristics of IDDPADS. Whole exome sequencing identified a novel missense variant in Phosphodiesterase 2A (PDE2A): NM_002599.4: c.1514T > C p.(Phe505Ser) that segregated with the disease status of individuals in these families. Retrospectively, we performed haplotype analysis that revealed a 3.16 Mb shared haplotype at 11q13.4 among three families suggesting a founder effect in this region. Moreover, we also observed abnormal mitochondrial morphology in patient fibroblasts compared to controls. Belonging to diverse age groups (13 years‐60 years), patients presented paroxysmal dyskinesia, developmental delay, cognitive abnormalities, speech impairment, and drug‐refractory seizures with variable onset of disease (as early as 3 months of age to 7 years). Together with the previous reports, we observed that intellectual disability, progressive psychomotor deterioration, and drug‐refractory seizures are consistent outcomes of the disease. However, permanent choreodystonia showed variability. We also noticed that the later onset of paroxysmal dyskinesia manifests severe attacks in terms of duration. Being the first report from Pakistan, we add to the clinical and mutation spectrum of PDE2A‐related recessive disease raising the total number of patients from six to 12 and variants from five to six. Together, with our findings, the role of PDE2A is strengthened in critical physio‐neurological processes.
Early changes in soluble intracellular adhesion molecule‐1 as prognostic biomarkers to immune checkpoint inhibitor
Authors: Ji Dongmei , Jiang Shiyu , Zhang Qunling , Wang Y. Ken , Zhang Jian , Shen Weina , Li Wenhua , Liu Rujiao , Wang Jessica , Mavis Cory , Gu Juan J. , Hu Xichun 
Published: June 2023

AbstractSerologic biomarker to predict clinical outcome is needed for immune checkpoint inhibitors (ICIs). We evaluated soluble intercellular adhesion molecules‐1 (sICAM‐1) as a predictor of response to ICIs treatment. Ninety‐five patients with cancer treated with ICI were studied. The serum sICAM‐1 levels of baseline, post two cycle therapy and end of therapy (EOT) were measured by enzyme‐linked immunoassay. We randomly assigned the patients into the primary cohort (n = 47) and validation cohort (n = 48). Serum sICAM‐1 post two cycle (277.7 ± 181.6 ng/mL) and EOT (403.9 ± 218.9 ng/mL) were significantly elevated compared to baseline (244.8 ± 153.8 ng/mL, p = 0.008 and p = 0.004, respectively). Early changes of sICAM‐1 (ΔsICAM‐1), deemed as sICAM‐1 after two cycles minus baseline, were assessed. Following ICI treatments, responders had significantly lower ΔsICAM‐1 compared with nonresponders in the primary cohort (p = 0.040) and the validation cohort (p = 0.026). High ΔsICAM‐1 was strongly associated with inferior progression‐free survival (PFS; (primary cohort: p = 0.001 and validation cohort: p = 0.002) and overall survival (OS; (primary cohort: p < 0.001 and validation cohort: p = 0.007). The ΔsICAM‐1 remained independently associated with worse PFS and OS in the primary cohort and the validation cohort. Subgroup analysis indicated patients whose sICAM‐1 significantly elevated had shorter PFS and OS in both anti‐PD‐1 and anti‐PD‐L1 treatment groups. Early change of serum sICAM‐1 could be used to monitor and predict clinical benefit of ICI therapy in patients with solid cancer.
The agential perspective: Countermapping the modern synthesis
Authors: Walsh Denis M. , Rupik Gregory 
Published: June 2023

AbstractWe compare and contrast two theoretical perspectives on adaptive evolution—the orthodox Modern Synthesis perspective, and the nascent Agential Perspective. To do so, we develop the idea from Rasmus Grønfeldt Winther of a ‘countermap’, as a means for comparing the respective ontologies of different scientific perspectives. We conclude that the modern Synthesis perspective achieves an impressively comprehensive view of a universal set of dynamical properties of populations, but at the considerable cost of radically distorting the nature of the biological processes that contribute to evolution. For its part, the Agential Perspective offers the prospect of representing the biological processes of evolution with much greater fidelity, but at the expense of generality. Trade‐offs of this sort are endemic to science, and inevitable. Recognizing them helps us to avoid the pitfalls of ‘illicit reification’, i.e. the mistake of interpreting a feature of a scientific perspective as a feature of the non‐perspectival world. We argue that much of the traditional Modern Synthesis representation of the biology of evolution commits this illicit reification.
Consumers' preference for downsizing over package price increases
Authors: Kim In Kyung 
Published: June 2023

AbstractIn this paper, I study how and why consumers react differently to package downsizing and package price increases that result in the same degree of unit price increases. Utilizing differential responses of South Korean milk manufacturers to the production cost rise in 2018, I first show that consumers strongly prefer downsizing to package price increases, and this tendency does not diminish over time. Then, I develop a theoretical model whose prediction is consistent with the empirical findings, providing a simple but novel explanation of why fully informed consumers would be less sensitive to downsizing than package price increases.
Tracking potential biosecurity incursions using publicly available images: A case of coconut rhinoceros beetle
Authors: Paudel Sulav , Jackson Trevor A. 
Published: June 2023

AbstractThe coconut rhinoceros beetle, Oryctes rhinoceros (L.), (CRB) is a major pest of coconut and oil palms that causes significant damage in the Asia/Pacific region. Traditional methods for surveillance and detection of CRB involve in‐person inspections, but these are expensive to carry out and were made impossible by travel restrictions during the COVID‐19 pandemic. In this paper, a method to remotely detect possible CRB incursions and assess damage levels using publicly available images is described. The method involves searching for pictures of palms and identifying those with the distinctive V‐shaped cuts in fronds characteristic of CRB feeding. The method was validated by examining palm images from known outbreak areas and those free from the pest. We found evidence of CRB damage in the previously unreported site of Dili, Timor Leste and possible evidence of CRB in the Solomon Islands even before it was first reported in 2015. Potential limitations and broader applications of this approach are also discussed.
Hey Google! Intelligent personal assistants and well‐being in the context of disability during COVID‐19
Authors: van Wingerden E. , Vacaru S. V. , Holstege L. , Sterkenburg P. S. 
Published: June 2023

AbstractBackgroundAmidst the greatest technological advancement that societies have seen, the (health)care and quality of life of all, and especially of vulnerable individuals, see unprecedented improvements. Intelligent personal assistants (IPAs), such as Google Home (GH), can easily be implemented in their daily lives to facilitate routines. Technology can offer significant benefits for individuals with impairments and/or limitations in achieving greater autonomy and well‐being. However, this opportunity still needs to be fully exploited, especially in long‐term care facilities. Furthermore, such potential may be particularly needed during social isolation due to health concerns, such as the COVID‐19 lockdowns and restrictions. We investigated the validity of implementing GH in residential care for individuals with visual impairments (VIs) and intellectual disabilities (IDs) and assessed the effects of a 10‐week intervention on self‐reported well‐being.MethodsWe used a mixed‐methods multiple case studies approach (N = 7) and performed intensive assessments (20 weeks), including self‐report well‐being questionnaires and observations focusing on well‐being, autonomy, social participation and GH experiences. Nonoverlap of all pairs analyses were performed for quantitative data indexing performance differences between intervention phases. Thematic analysis was performed for the qualitative data.ResultsWe found meaningful improvements in well‐being in five clients, while all rated the experience of using GH positively.ConclusionsOur findings from the quantitative and qualitative analyses document that individuals with VI and/or ID benefit from IPAs in fostering better autonomy by facilitating access to information and entertainment. Further implications and possible barriers to large‐scale implementation of IPAs in residential care are discussed.
Hybridization in late stages of speciation: Strong but incomplete genome‐wide reproductive isolation and ‘large Z‐effect’ in a moving hybrid zone
Authors: Caeiro‐Dias Guilherme , Brelsford Alan , Meneses‐Ribeiro Mariana , Crochet Pierre‐André , Pinho Catarina 
Published: June 2023

AbstractIn organisms reproducing sexually, speciation occurs when increasing divergence results in pre‐ or post‐zygotic reproductive isolation between lineages. Studies focusing on reproductive isolation origin in early stages of speciation are common and many rely on genomic scans to infer introgression providing limited information on the genomic architecture of reproductive isolation long‐term maintenance. This study analyses a natural hybrid zone between two species in a late stage of speciation. We used ddRADseq genotyping in the contact betweenPodarcis bocageiandP. carbonellito examine admixture extent, analyse hybrid zone stability and assess genome‐wide variation in selection against introgression. We confirmed strong but incomplete reproductive isolation in a bimodal hybrid zone. New findings revealed population genetic structure withinP. carbonelliin the contact zone; geographical and genomic clines analysis suggested strong selection against gene flow, but a relatively small proportion of the loci can introgress, mostly within the narrow contact zone. However, geographical clines revealed that a few introgressed loci show signs of potential positive selection, particularly intoP. bocagei. Geographical clines also detected a signal of hybrid zone movement towardsP. bocageidistribution. Genomic cline analysis revealed heterogeneous patterns of introgression among loci within the syntopy zone, but the majority maintain a strong association with the genomic background of origin. However, incongruences between both cline approaches were found, potentially driven by confounding effects on genomic clines. Last, an important role of the Z chromosome in reproductive isolation is suggested. Importantly, overall patterns of restricted introgression seem to result from numerous strong intrinsic barriers across the genome.