bluuebunny/crossref_metadata_2025_split huggingface dataset:
A retrospective view of the relationship of soluble Fas with anemia and outcomes in chronic kidney disease
Authors: Andrade Jessica Felício , Dalboni Maria A. , Clemente Otavio Candido , Silva Beatriz Moreira , Domingues Barbara Formaggio , Rodrigues Adelson Marcal , Canziani Maria Eugenia , Zarjou Abolfazl , Cendoroglo Miguel , Goes Miguel Angelo 
Published: June 2023

Background
Anemia is common in chronic kidney disease (CKD) and is associated with outcomes. In addition, serum soluble Fas (sFas) levels are related to anemia and erythropoietin (EPO) resistance.

Objectives
Firstly, to compare clinical data and serum levels of sFas, EPO, and pro-inflammatory markers between patients with non-dialytic CKD (NDD-CKD) and healthy subjects. Subsequently, to compare and evaluate the relationship of serum EPO, sFas levels with anemia, and outcomes in patients with NDD-CKD over a long follow-up period.

Methods
We performed a retrospective study in 58 NDD-CKD patients compared with 20 healthy subjects on complete blood count, kidney function, serum EPO, sFas, and inflammatory markers (CRP, IL- 6, and IFN-γ) at baseline. We then compared the same baseline data between patients with NDD-CKD who evolved to anemia and those who did not have anemia over the follow-up. We also evaluated the frequency of outcomes in patients with CKD with higher sFas levels. Finally, we performed a multivariate analysis of factors associated with CKD anemia.

Results
There were lower eGFR and Hb but higher serum inflammatory markers, sFas levels, sFas/eGFR, and EPO/Hb ratios in patients with NDD-CKD. Comparatively, on the other hand, NDD-CKD patients with anemia had lower eGFR but were older, had more diabetes, and had higher sFas/ eGFR, EPO/Hb ratios, and serum levels of IL-6 and sFas than NDD-CKD without anemia for an extended period. In addition, there was an association in a multivariate analysis of diabetes, age, and sFas levels with kidney anemia. Furthermore, there were higher frequencies of outcomes in increased serum sFas levels.

Conclusion
As an elective risk factor, serum sFas levels, in addition to age and diabetes, were independently associated with kidney anemia for an extended period. Thus, more studies are necessary to analyze the proper relationship of sFas with kidney anemia and its outcomes and therapy in CKD.
Biomarkers of immunothrombosis and polymorphisms of IL2, IL6, and IL10 genes as predictors of the severity of COVID-19 in a Kazakh population
Authors: Yessenbayeva Assiya , Apsalikov Bakytbek , Massabayeva Meruyert , Kazymov Maksut , Shakhanova Aizhan , Mussazhanova Zhanna , Kadyrova Irina , Aukenov Nurlan , Shaimardanov Nurlan 
Published: June 2023

ObjectivesTo study the role of biological markers of immunothrombosis and polymorphisms of cytokine genesIL2,IL6,IL10and their influence on the severity of COVID-19 in a Kazakh population.MethodsA total of 301 patients of Kazakh nationality with a confirmed diagnosis of COVID-19 participated in the retrospective study, including 142 patients with severe and 159 with a mild course. Single nucleotide polymorphismsIL2Rrs1801274,IL6rs2069840, andIL10rs1800872 were genotyped by real-time PCR. Activated partial thromboplastin time, normalized ratio, prothrombin index, prothrombin time, fibrinogen prothrombin time, fibrinogen, D-dimer, and C-reactive protein analysis were also conducted.ResultsThe average age of patients with severe COVID-19 is higher than of patients with mild COVID-19 (p= 0.03). The findings showed that fibrinogen, D-dimer, and C-reactive protein were significantly greater in the group of patients with severe COVID-19 (p= 0.0001). A very strong correlation between the severity of COVID-19 with the D-dimer and C-reactive protein (p= 0.9) (p= 0.02) was found.ConclusionThe results of our study confirm that D-dimer, fibrinogen, and CRP are biomarkers of inflammation and hypercoagulation that serve as predictors of immunothrombosis affecting the severity of COVID-19. D-dimer is also associated withIL10rs1800872 gene polymorphism in the Kazakh population with severe COVID-19.
Disease course of non-radiographic axial spondyloarthritis: Data from a long-term retrospective observational cohort
Authors: Kwon Oh Chan , Kim Yong-Gil , Park Min-Chan 
Published: June 2023

Background
Disease course of non-radiographic axial spondyloarthritis (axSpA) has been extensively studied in non-Asian population; however, there are limited data in Asian population. This study aimed to evaluate the long-term disease course of non-radiographic axSpA in Asian patients and identify factors associated with progression to radiographic axSpA.

Methods
In this retrospective observational cohort study, 56 Korean patients newly diagnosed with non-radiographic axSpA between 2006 and 2015 were included. All patients fulfilled the Assessment of SpondyloArthritis international Society classification criteria for axSpA, and did not fulfil the radiological criterion of the 1984 modified New York criteria. Disease course was assessed by the rate of progression to radiographic axSpA. Factors associated with the risk of progression to radiographic axSpA were assessed using multivariable Cox proportional hazard regression analysis.

Results
The mean age at baseline was 31.4±13.3 years, and 37 (66.1%) patients were men. Over a mean observation period of 8.4±3.7 years, 28 (50.0%) patients progressed to radiographic axSpA. In multivariable Cox proportional hazard regression analysis, the presence of syndesmophytes at diagnosis (adjusted hazard ratio [HR]: 4.50, 95% confidence interval [CI]: 1.54–13.15, p = 0.006) and active sacroiliitis on magnetic resonance imaging (MRI) at diagnosis (adjusted HR: 5.88, 95% CI: 2.05–16.82, p = 0.001) were significantly associated with a higher risk of progression to radiographic axSpA, whereas longer exposure to tumor necrosis factor inhibitors (TNFis) was significantly associated with a lower risk of progression to radiographic axSpA (adjusted HR: 0.89, 95% CI: 0.80–0.98, p = 0.022).

Conclusion
During long-term follow-up, a substantial proportion of Asian patients with non-radiographic axSpA progressed to radiographic axSpA. The presence of syndesmophytes and active sacroiliitis on MRI at the time of non-radiographic axSpA diagnosis were associated with a higher risk of progression to radiographic axSpA, while longer exposure to TNFis was associated with a lower risk of progression to radiographic axSpA.
Morphometric Findings in Medial Patellofemoral Ligament Rupture Compared to Individually-Matched Controls
Authors: Ayşe Gül Kabakci  , Emre Öğüt  , Volkan Tolga Tekbaş  , Memduha Gülhal Bozkir  
Published: June 2023

BACKGROUND
The purpose of the present study was to evaluate patellar height and trochlear groove angle in individuals with and without medial patellofemoral ligament rupture for surgical reconstruction and possible clinical use.
METHODS
The study had a retrospective design, and included 149 people (53 females, 96 men) who were between the ages of 18 and 36 admitted to the Orthopedic Clinic of Bartın State Hospital with various complaints in knee joints and different preliminary diagnoses between January 2005 and December 2020. The study population was examined as two groups, those with and without medial patellofemoral rupture. The study included 61 patients with medial patellofemoral ligament rupture and 88 patients without medial patellofemoral ligament rupture. Patellar morphology, patellar height, trochlear morphology, and patellar alignment were measured from digital MRI images.
RESULTS
As a result of the study, while significant differences were detected in trochlear groove angle, there wasn’t significant differences in patella elevation (patellar height) between the groups (with and without medial patellofemoral ligament rupture).
CONCLUSIONS
Our study has versatile evaluation parameters, it will make a significant contribution to the literature.
X-ray shielding properties of bismuth-borate glass doped with rare earth ions
Authors: Kheswa Bonginkosi Vincent 
Published: June 2023

Abstract
In this study, the X-ray shielding competence of the 15Bi2O3 + 75H3BO2 + 10Sm2O3, 15Bi2O3 + 75H3BO2 + 10Nd2O3, and 15Bi2O3 + 75H3BO2 + 10CeO2 glasses was investigated using the Phy-X/PSD simulation software and validated using the XCOM simulation software. The Sm3+-doped bismuth-borate glass gave the highest linear attenuation coefficients and effective atomic number, and the lowest half-value layer, tenth-value layer, and mean free path. Thus, it is the most effective radiation shielding material compared to the Nd3+- and Ce4+-doped bismuth-borate glasses. It was also observed that the Sm3+-doped bismuth-borate glass also has better radiation-shielding competence than various glass systems that have been recently investigated in the literature.
Performance analysis of a flexible wearable antenna with low SAR for biomedical application
Authors: Kuppusamy Ramasamy M. , Abdulkareem Sapna B. 
Published: June 2023

Abstract
This article presents a conformal monopole antenna for wearable application in ISM band frequency of 2.45 GHz. The antenna has a return loss of 50.18 dB with good radiation performance. The gain of the antenna is 1.09 dBi which is improved to 3.28 dBi using a metasurface consisting of 3 × 3 array elements. The proposed metamaterial integrated antenna is fabricated on 1 mm thick flexible PDMS substrate. The metamaterial improves the gain while reducing the specific absorption rate (SAR) of the antenna. The geometry size of the metamaterial integrated antenna is 50 × 50 × 24 mm3. The loading effect of antenna by body is analyzed with a hand phantom model. Flexibility and conformability of antenna is analyzed by bending the antenna with various radii in x and y direction. Measured results of the fabricated prototype demonstrate the safety of the suggested wearable antenna for biomedical applications.
Generalizing the Elo rating system for multiplayer games and races: why endurance is better than speed
Authors: Powell Ben 
Published: June 2023

Abstract
We introduce a non-standard generalization of the Elo rating system for competitions involving two or more participants. The new system can be understood as an online estimation algorithm for the parameters of a Plackett–Luce model which can be used to make probabilistic forecasts for the results of future competitions. The system’s distinguishing feature is the way it treats competitions as sequences of elimination-type rounds that sequentially identify the worst competitors rather than sequences of selection-type rounds that identify the best. The significance of this important modelling choice is discussed and its consequences are explored. Finally, our generalized Elo system’s predictive power is demonstrated using data from Formula One racing.
Safety decision analysis of collapse accident based on “accident tree–analytic hierarchy process”
Authors: Ren Xiaoyu , Du Zhaoli , Wang Jinrong , Yang Fen , Su Tian , Wei Wei 
Published: June 2023

Abstract
To reduce the hazards of collapse accidents in the construction process and to ensure that the lives, health, and property of construction workers are protected, this study used the theory of safety system engineering to identify the hazards of collapse accidents, analyze the hazards, predict the consequences, evaluate the systemic risks, and evaluate the effects and improve them. At the same time, the risk factors of collapse were evaluated qualitatively and quantitatively by using the analysis methods of fault tree analysis (FTA) and the analytic hierarchy process (AHP). Finally, according to the evaluation results, the main factors causing collapse accidents were found; this provided a reliable and practical basis for the prevention of collapse accidents. Then, according to the decisive factors, corresponding measures were taken in advance to achieve the aim of preventing and controlling collapse accidents. The results show that equipment maintenance, material inspection, and construction site safety management play an important role in preventing collapse accidents.
Synthesis of Ag and Cu nanoparticles by plasma discharge in inorganic salt solutions
Authors: Horák Jakub , Nikiforov Anton , Krčma František , Březina Matěj , Kozáková Zdenka , Dostál Lukáš , Kalina Michal , Kalina Lukáš 
Published: June 2023

Abstract
In recent years, nanoparticles have emerged as an important player in a broad range of applications, especially thanks to recent advances in their synthesis. The silver and copper nanoparticles are often used due to their antibacterial and fungicidal activities, and this article presents the results of the nanoparticle synthesis using electrical glow discharge generated directly in a volume of their salt solutions. Therefore, there is no influence of air (i.e. reactive nitrogen species) as it is usual in other commonly used approaches. Nanoparticles were prepared under various experimental conditions, and they were characterized by ultraviolet/visible spectrometry, dynamic light scattering, X-ray photoelectron spectroscopy, and high-resolution scanning electron microscopy. Particles were produced without any surfactant or stabilizing agent, and some of them showed higher resistance against agglomeration during their short-term (days) storage. The nanoparticle formation mechanism was confirmed by the fast camera imaging. Thus, the developed approach can be applied for simple environmentally friendly nanoparticle production for various applications.
Comprehensive behavioral study of C57BL/6.KOR-ApoEshl mice
Authors: Ueno Hiroshi , Takahashi Yu , Murakami Shinji , Wani Kenta , Miyazaki Tetsuji , Matsumoto Yosuke , Okamoto Motoi , Ishihara Takeshi 
Published: June 2023

Abstract

Background
Apolipoprotein E (ApoE) is associated with Alzheimer’s disease (AD) and cognitive dysfunction in elderly individuals. There have been extensive studies on behavioral abnormalities in ApoE-deficient (Apoeshl) mice, which have been described as AD mouse models. Spontaneously hyperlipidemic mice were discovered in 1999 as ApoE-deficient mice due to ApoE gene mutations. However, behavioral abnormalities in commercially available Apoeshl mice remain unclear. Accordingly, we aimed to investigate the behavioral abnormalities of Apoeshl mice.

Results
Apoeshl mice showed decreased motor skill learning and increased anxiety-like behavior toward heights. Apoeshl mice did not show abnormal behavior in the Y-maze test, open-field test, light/dark transition test, and passive avoidance test.

Conclusion
Our findings suggest the utility of Apoeshl mice in investigating the function of ApoE in the central nervous system.
Viajes y circunstancias de Pedro Cubero Sebastián
Authors: Alba Sanz R. 
Published: June 2023

Sucinto recorrido por la vida, los viajes y las obras de Pedro Cubero Sebastián (1645?-1700?), el primer viajero en rodear el mundo en sentido inverso al de las naos de Elcano, con la particularidad de hacer la mayor parte de su camino por tierra. Se presta especial atención a su recorrido por el Próximo Oriente. Se establecen también algunas precisiones sobre la cronología de su vida y viajes.Palabras clave: Pedro Cubero Sebastián, Viajes siglo XVII, Vuelta al mundo, Biografía, Cronología, Próximo Oriente. Abstract:A concise look at the life, travels and works of Pedro Cubero Sebastián (1645?-1700?), the first person to travel around the world in the opposite direction to the ship of Elcano, with the special feature that he did it most of the time by land. Especially emphasized is his way through the Near East. There are some precisions on the chronology of his life and travels, too.Keywords: Pedro Cubero Sebastian, Travels in the 17th century, Around the world, Biography, Chronology, Near East.
The use of Design Thinking Method in applied research to integrate the library in distance learning platforms with a learning object
Authors: Centeno Alayón Purísima 
Published: June 2023

This work aimed to integrate the most in-demand library services and resources in distance education platforms through the creation of a learning object for the Natural Sciences Faculty, at the University of Puerto Rico, Río Piedras Campus. For this object, the Design Thinking Method was applied, which consists of the following steps: empathizing, defining, ideating, prototyping, and testing. The research approach was mixed. Some information was gathered from participatory observation and netnography, as qualitative methodologies, to identify the needs of the academic community. In addition, the visits statistics to the Centro de Información y Tecnología web pages were considered from the quantitative perspective to contrast them with the findings of the qualitative part. The study found that the resources and services with the greatest demand were journals, databases, remote access, and interlibrary loan. Identifying needs early on helps design solutions that satisfy the user. When applying the Design Thinking Method and, in its first step, empathy considered the library services needs from the beginning. This helped the rest of the steps of the method to be responsive to the needs and to make an informed decision. The product, a learning object, responded to the needs of the Natural Sciences Community, but can be reusable by other organizations by making the necessary adjustments as needed.
Students' Creative Thinking Skills on Reaction Rate Topic through Contextual Teaching and Learning Model
Authors: Sihaloho Mangara , Tungkagi Ika Riyana , Ischak Netty Ino , Purwati Dewi Budi , La Kilo Akram 
Published: June 2023

This research aims to analyze the contextual teaching and learning (CTL) model on students' creative thinking skills on the reaction rate topic. This quantitative research used true experimental design of pretest-posttest control. The samples used in this study were from 11th grade at SMA Negeri 1 Pinolosian. The experimental class sample was given treatment of the CTL learning model while the control class used conventional learning, respectively, were 31 and 30 students of 93 populations. Based on a questionnaire, students' creative thinking skills were obtained through observation during the learning process. The data analysis of the test instrument was carried out through a validity test using the product-moment correlation technique (significant level = 0.05), Lilliefors normality test, homogeneity of variance test and ttest. The CTL implementation questionnaire and instrument test data were converted into percentages and categorized. The results showed that the application of the CTL model had a positive effect on students' creative thinking abilities, evidenced by the average score of students in the experimental class before and after treatment increased from 14.55 to 74.84. Otherwise, in the control class, the scores were 30.59 to 33.56. The percentage of students' achievement in creative thinking aspects in the experimental class was good (61%-80%) while the control class was less good (21%-40%). The creative thinking abilities of both classes are very different, which is also reflected in the learning outcomes. The value of tcount (2.240) was greater than ttable (2.042) at the significant level = 0.05, and the hypothesis of H0 was rejected, or H1 was accepted. The application of the CTL learning model positively influenced students' creative thinking skills on the reaction rate material. Students' low originality abilities compared to fluency, flexibility, and elaboration abilities were also discussed.
The floristic composition, morphometric and the adaptation of a new species: Malva subovata in the matorral of Algeria (Djbel fellaoucen)
Authors: GHALEM Sarra , HASSANI Faiçal , ABDELLI Imane , BELHADJI Amina , BEKKAL BRIKCI Sohayb 
Published: June 2023

This study is based on a ruderal species: Malva subovata = Lavatera maritima which should normally grow in the littoral, under maritime influence. Its presence in the matorrals is highlighted for the first time. as it has been found far from its natural habitat. The comparison of the different biological and morphological spectra shows the importance of the therophytes that confirms the phenomenon of degradation. This degradation shows a depletion of the floristic procession, especially concerning sylvatic species which have given way to ephemeral therophytes and chamæphytes. Despite the presence of a shrubby layer, it is no longer a question of a forest ecosystem but of a pre-forest ecosystem. To better understand the characteristics of this Malvaceae in terms of resistance and adaptation in matorrals, we often use the phytomass of all anthropozoic formations and more specifically the phytomass of the species that characterize this group. In our case, this is Malva subovata. The results of the morphometric study constitute a basic element for the evaluation of the adaptive potential of our Lavatère against the degradation factors.
Deciphering the myth of cold tolerance in soybean: An overview of molecular breeding applications
Authors: JIAN Wei , QIANG Qiu , Guan YIJUN  , Ran QIUYAN  , JIANING Guan , QIAN Zhao , CHUNGANG Zhao , RASHEED Adnan , Wang YUEQIANG  , CHEN Liang , Nazer MANZOOR  , QARI Sameer H. , BARQAWI Aminah A. , WAHAB Hafiz A. , ZHIMING Xie , Wang XIAOXUE  
Published: June 2023

The soybean is a source of several dietary components, including milk, protein, and oil. Cold stress has significantly curtailed soybean growth and yield in large areas and caused a high risk to global food security. The main objective of soybean breeders is to improve soybean resistance to cold stress. Conventional breeding approaches have made significant progress in developing cold tolerance in soybean; however, the high cost and complex genetic mechanism of cold tolerance hindered the large scale of these techniques. Molecular tools like quantitative trait loci (QTL), genome-wide association studies (GWAS), transcription factors (TFs), genetic engineering, and transcriptome have been used to identify cold tolerant genes/QTL and to develop soybean cultivars tolerant to cold stress. Clustered, regularly interspaced short palindromic repeats (CRISPR/Cas9) is used to increase the abiotic stress tolerance in soybean; however, its use to edit the cold tolerance genes in soybean is limited. Mapping of QTL has accelerated the master-assisted selection (MAS) in soybean. This review presents a detailed overview of molecular techniques and their use in developing cold-tolerant soybean cultivars. Using CRISPR/Cas9 would increase the speed of molecular breeding for cold tolerance in soybean. This information will assist soybean researchers in uncovering the basis of cold stress tolerance in soybean and adopting the most suitable way to breed the cold tolerant cultivars which can thrive under the extreme pressure of cold stress.