bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4‐Human Leukocyte Antigen‐DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension
Authors: Hafeez Neha , Kirillova Anna , Yue Yunshan , Rao Rashmi J. , Kelly Neil J. , El Khoury Wadih , Al Aaraj Yassmin , Tai Yi‐Yin , Handen Adam , Tang Ying , Jiang Danli , Wu Ting , Zhang Yingze , McNamara Dennis , Kudryashova Tatiana V. , Goncharova Elena A. , Goncharov Dmitry , Bertero Thomas , Nouraie Mehdi , Li Gang , Sun Wei , Chan Stephen Y. 
Published: March 2023

Background
Pulmonary arterial hypertension (PAH) is a complex, fatal disease where disease severity has been associated with the single nucleotide polymorphism (SNP) rs2856830, located near the human leukocyte antigen DPA1 (HLA‐DPA1) gene. We aimed to define the genetic architecture of functional variants associated with PAH disease severity by identifying allele‐specific binding transcription factors and downstream targets that control endothelial pathophenotypes and PAH.

Methods and Results

Electrophoretic mobility shift assays of oligonucleotides containing SNP rs2856830 and 8 SNPs in linkage disequilibrium revealed functional SNPs via allele‐imbalanced binding to human pulmonary arterial endothelial cell nuclear proteins. DNA pulldown proteomics identified SNP‐binding proteins. SNP genotyping and clinical correlation analysis were performed in 84 patients with PAH at University of Pittsburgh Medical Center and in 679 patients with PAH in the
All of Us
database. SNP rs9277336 was identified as a functional SNP in linkage disequilibrium (
r
2
>0.8) defined by rs2856830, and the minor allele was associated with decreased hospitalizations and improved cardiac output in patients with PAH, an index of disease severity. SNP pulldown proteomics showed allele‐specific binding of nuclear ACTN4 (alpha actinin 4) protein to rs9277336 minor allele. Both ACTN4 and HLA‐DPA1 were downregulated in pulmonary endothelium in human patients and rodent models of PAH. Via transcriptomic and phenotypic analyses, knockdown of HLA‐DPA1 phenocopied knockdown of ACTN4, both similarly controlling cell structure pathways, immune pathways, and endothelial dysfunction.

Conclusions
We defined the pathogenic activity of functional SNP rs9277336, entailing the allele‐specific binding of ACTN4 and controlling expression of the neighboring HLA‐DPA1 gene. Through inflammatory or genetic means, downregulation of this ACTN4‐HLA‐DPA1 regulatory axis promotes endothelial pathophenotypes, providing a mechanistic explanation for the association between this SNP and PAH outcomes.
Static and dynamic functional connectome reveals reconfiguration profiles of whole-brain network across cognitive states
Authors: Zhang Heming , Meng Chun , Di Xin , Wu Xiao , Biswal Bharat 
Published: March 2023

Abstract
Assessment of functional connectivity (FC) has revealed a great deal of knowledge about the macroscale spatiotemporal organization of the brain network. Recent studies found task-versus-rest network reconfigurations were crucial for cognitive functioning. However, brain network reconfiguration remains unclear among different cognitive states, considering both aggregate and time-resolved FC profiles. The current study utilized static FC (sFC, i.e., long timescale aggregate FC) and sliding window–based dynamic FC (dFC, i.e., short timescale time-varying FC) approaches to investigate the similarity and alterations of edge weights and network topology at different cognitive loads, particularly their relationships with specific cognitive process. Both dFC/sFC networks showed subtle but significant reconfigurations that correlated with task performance. At higher cognitive load, brain network reconfiguration displayed increased functional integration in the sFC-based aggregate network, but faster and larger variability of modular reorganization in the dFC-based time-varying network, suggesting difficult tasks require more integrated and flexible network reconfigurations. Moreover, sFC-based network reconfigurations mainly linked with the sensorimotor and low-order cognitive processes, but dFC-based network reconfigurations mainly linked with the high-order cognitive process. Our findings suggest that reconfiguration profiles of sFC/dFC networks provide specific information about cognitive functioning, which could potentially be used to study brain function and disorders.
Interfaith Marriage in Indonesia: Polemics and Perspectives of Religious Leaders and Community Organizations
Authors: Adil Muhammad , Jamil Syahril 
Published: March 2023

Abstract
The increasing number of interfaith marriages has recently sparked polemics in society. This study aims to investigate the polemics between the ulama (Muslim religious scholars) and interfaith marriage counseling activists and discuss the arguments among religious community organizations and activists supporting interfaith marriage. In addition, this research also investigates how polemics were conveyed through online media. The present investigation was based on a qualitative approach, administering data sources in the form of observations on online media regarding interfaith marriage. Data analysis employed an interpretive method involving three stages: restatement, description, and interpretation. The restatement was accomplished by citing online news containing arguments relevant to this research’s theme. The description was conducted by correlating all research data to find patterns of information. The interpretation was constructed by focusing on the social context of the data to reveal the meaning behind experts’ statements or ideas and to draw conclusions afterward. The results indicated concerns regarding the understanding and practice in a society where interfaith marriage was assumed to be permissible. In addition, the organizations supporting interfaith marriage viewed the Marriage Law as multi-interpretable and sparked controversies in the community.
China’s Bifurcated Space Diplomacy and Institutional Density
Authors: Li Kunhan , Mayer Maximilian 
Published: March 2023

Abstract
This article compares two central pillars of China’s space programme and observes that Chinese space diplomacy is not uniform regarding international scientific co-operation either in its approaches or in results. In the case of the Chinese Space Station programme, the China National Space Administration went through existing United Nations (UN) channels and successfully attracted international partners. However, the International Lunar Research Station has avoided UN channels and used national and bilateral platforms. This bifurcation in approaches and results offers an intriguing puzzle concerning international co-operation: practices of institutionalised multilateral co-operation and areas of state-centric bilateral co-operation co-exist in this case and further complicate the issue of space diplomacy. To propose a potential explanation, it is argued here that a crucial intermediate variable — institutional density — requires further theorising, as it seems to influence strategic choices about space diplomacy, which may lead to success or failure.
The dolor, ira and Vengeance Cycle in Paul the Deacon’s Historia Langobardorum
Authors: Demarchi Nicole 
Published: March 2023

Abstract
This essay explores the role and meaning of the emotional term dolor in the scenarios of vengeance represented by the Lombard scholar Paul the Deacon (c.720–799) in his work Historia Langobardorum. First, after contextualising the work and analysing the concept of aristocratic honour and vengeance outlined by the author in the text, this essay examines the episodes in which dolor is associated with revenge. Second, starting from the work itself, the paper constructs the emotional script of dolor, namely the little scenario that a character plays out – as sequences of events, actions and social interactions – when he or she feels this emotion. Finally, it examines how the author evaluates dolor positively or negatively in relation to social and gender norms.
“I’m Fixing a Hole Where the Rain Gets in, and Stops My Mind from Wandering”: Approaching Sustainable Climate Change Adaptations
Authors: Aall Carlo , Meyer-Habighorst Christiane , Gram-Hanssen Irmelin , Korsbrekke Mari Hanssen , Hovelsrud Grete 
Published: March 2023

Abstract
Sustainable development is a challenging field of research, colored by the paradoxes of modernity and development, and the trade-offs involved in balancing the “sustainable” and “development” sides of the various sustainable development goals. We must take these overarching challenges into account when entering a more specific discussion of what a concept of sustainable climate change adaptation may entail. This article reviews the history of this concept, including insights provided by the recent publications composing a special collection of Weather, Climate, and Society on the topic of sustainable climate change adaptation. This collection reflects on why and how the term sustainable development should be included in our understandings of and efforts toward climate change adaptation and proposes a preliminary framework for distinguishing between conventional and sustainable adaptation.

Significance Statement
This article reviews the history of the term “sustainable climate change adaptation” and reflects on the relationship between sustainable development and climate change adaptation efforts. It ends by proposing a framework for distinguishing between conventional and sustainable adaptation.
The role of intellectual disability and emotional regulation in the autism–depression relationship
Authors: Sáez-Suanes Gema P , García-Villamisar Domingo , Del Pozo Armentia Araceli 
Published: March 2023

Research shows significant rates of depressive symptoms in people with autistic spectrum disorder and intellectual disabilities. Finding factors related to the development of depression in autism spectrum disorder and intellectual disability is necessary. Emotion regulation is associated with depression in autism spectrum disorder and intellectual disability. The role of the intellectual disability in this relationship is not clear, so it is necessary to clarify it. One hundred twenty-one adults (M = 35.46 years, SD = 9.46) with autism spectrum disorder and intellectual disabilities were evaluated to verify moderating role of intellectual disability and mediating role of emotion regulation. A moderated mediation analysis supported the moderated role of mild intellectual disability in the relationship mediated by emotional dysregulation between autism spectrum disorder and depression symptoms. These findings suggest that interventions designed to prevent or reduce depressive symptoms in people with autism spectrum disorder and mild intellectual disability should include among their goals emotional regulation. Lay abstract Many people with autism and intellectual disability have significant levels of depressive symptoms. However, this relationship is not clear. For this reason, knowing the factors that are associated with having depression in autism and intellectual disability is important. Emotion regulation is associated with depression in autism spectrum disorder and intellectual disability. After evaluating a group of people with autism and intellectual disability, we found that people with mild intellectual disability have problems regulating their emotions which lead them to develop depressive symptoms. These findings suggest that interventions designed to prevent or reduce depressive symptoms in people with autism spectrum disorder and mild intellectual disability should include among their goals emotional regulation.
Looking into backstage discussions in social work: A qualitative synthesis of recent empirical findings
Authors: Taghizadeh Larsson Annika , Olaison Anna , Österholm Johannes 
Published: March 2023

Summary Social work practice has a history of collegial, intra-, and interprofessional discussions that take place backstage, that is, without the presence of clients. Because of their backstage character, these discussions may be considered even more important to examine than meetings at which clients are present and that are in a way already open to the public. The purpose of the present review was to provide insight into this practice by identifying and synthesizing recent empirical findings from existing studies using naturalistic data, published in English in peer-reviewed journals. Findings We identified four types of interaction among practitioners in relation to the case discussed and three types of content that were raised and shared, as well as an apparent mismatch between formal reasons for the discussions and the purpose they serve in practice. A lack of common vocabulary for conceptualizing the discussions and of attention given to their backstage character was identified in the included studies. Applications The review highlights an important area for further research and stresses the importance of not being blinded by formal purposes or ideological underpinnings in examining intra- and interprofessional discussions in social work; it shows that it is important to look into what is actually going on in practice.
Dual antiplatelet Use for extended period taRgeted to AcuTe ischemic stroke with presumed atherosclerotic OrigiN (DURATION) trial: Rationale and design
Authors: Kim Joon-Tae , Kang Jihoon , Kim Beom Joon , Kim Jun Yup , Han Moon-Ku , Cho Ki-Hyun , Park Man-Seok , Choi Kang-Ho , Park Jong-Moo , Kang Kyusik , Kim Yong Soo , Lee Soo Joo , Kim Jae Guk , Cha Jae-Kwan , Kim Dae-Hyun , Park Tai Hwan , Park Sang-Soon , Choi Jin Kyo , Lee Kyungbok , Park Kwang-Yeol , Jeong Hae-Bong , Lee Jun , Kwon Doo Hyuk , Cho Yong-Jin , Hong Keun-Sik , Park Hong-Kyun , Lee Byung-Chul , Yu Kyung-Ho , Oh Mi Sun , Lee Minwoo , Kim Dong-Eog , Gwak Dong-Seok , Choi Jay Chol , Kim Joong-Goo , Kang Chul-Hoo , Kwon Jee-Hyun , Kim Wook-Joo , Shin Dong-Ick , Yum Kyu Sun , Sohn Sung Il , Hong Jeong-Ho , Park Hyungjong , Kim Chulho , Lee Sang-Hwa , Lee Juneyoung , Gorelick Philip B , Norrving Bo , Bae Hee-Joon 
Published: March 2023

Rationale: The optimal duration of dual antiplatelet therapy (DAPT) with clopidogrel-aspirin for the large artery atherosclerotic (LAA) stroke subtype has been debated. Aims: To determine whether the 1-year risk of recurrent vascular events could be reduced by a longer duration of DAPT in patients with the LAA stroke subtype. Methods and study design: A total of 4806 participants will be recruited to detect a statistically significant relative risk reduction of 22% with 80% power and a two-sided alpha error of 0.05, including a 10% loss to follow-up. This is a registry-based, multicenter, prospective, randomized, open-label, blinded end point study designed to evaluate the efficacy and safety of a 12-month duration of DAPT compared with a 3-month duration of DAPT in the LAA stroke subtype. Patients will be randomized (1:1) to either DAPT for 12 months or DAPT for 3 months, followed by monotherapy (either aspirin or clopidogrel) for the remaining 9 months. Study outcomes: The primary efficacy outcome of the study is a composite of stroke (ischemic or hemorrhagic), myocardial infarction, and all-cause mortality for 1 year after the index stroke. The secondary efficacy outcomes are (1) stroke, (2) ischemic stroke or transient ischemic attack, (3) hemorrhagic stroke, and (4) all-cause mortality. The primary safety outcome is major bleeding. Discussion: This study will help stroke physicians determine the appropriate duration of dual therapy with clopidogrel-aspirin for patients with the LAA stroke subtype. Trial registration: URL: https://cris.nih.go.kr/cris . CRIS Registration Number: KCT0004407
Atrial Appendage Aneurysms: Natural History and Outcomes
Authors: Penfold Michael P. , Haq Ikram-Ul , Connolly Heidi M. , Dearani Joseph A. , Schaff Hartzell V. , Miranda William R. , Asirvatham Samuel J. , Killu Ammar M. , Arghami Arman , Stephens Elizabeth H. 
Published: March 2023

Background Left (LAAA) and right atrial appendage aneurysms (RAAA) are rare entities, and their natural history, management, and long-term outcomes are not well studied. Methods This retrospective review includes all patients from 2000 to 2021 with atrial appendage aneurysms at our institution identified using an electronic search tool. LAAA and RAAA were confirmed using multimodality imaging and intraoperative findings. Results We identified 13 (87%) patients with LAAA and 2 (13%) with RAAA. At diagnosis, 11 (73%) were female, mean age was 51.4  ±  18.8 years, and ejection fraction 56.5  ±  13.1%. Three (20%) patients had congenital heart disease including 2 (13%) with atrioventricular septal defects and 1 (7%) with congenitally corrected transposition. LAAA/RAAA was diagnosed due to new-onset atrial fibrillation (AF) in 6 (40%) patients and embolic stroke in 2 (13%). Ten patients had preexisting AF diagnosed 2.9  ±  1.4 years earlier at a mean age of 50.2  ±  15.5 years. Thrombus within the aneurysm was identified in 2 (15%) LAAA patients. All patients were on anticoagulation and follow-up of the cohort from diagnosis was 7.1  ±  6.2 years. Eleven (73%) patients were surgically managed with 7 (64%) lesions excised, 1 (9%) stapled, and 3 (27%) ligated. Postoperative complications occurred in 2 (18%) patients with 1 (7%) developing tricuspid regurgitation and another with pericardial effusion and tamponade. Conclusions Atrial appendage aneurysm is a rare disease and nearly half of patients present with AF. Surgical treatment with concomitant AF ablation is a reasonable and safe management option.
Impact of Industry 4.0 Technology on International Posting of Workers
Authors: Bednarz Joanna , Schuster Carola , Rost Martin 
Published: March 2023

Posting of workers is a common reality in all EU Member States and in all export-oriented industries. The problem relates to existing travel restrictions in connection with the COVID-19 pandemic and in the context of the carbon footprint of business travel. In this context, the development of new Industry 4.0 technologies plays a significant role. The aim of the article is to identify the impact of Industry 4.0 technology on the international posting of workers in light of the COVID-19 pandemic on example of the German chemical industry. The basis of the analysis are two factor conditions of the Diamond Model of M.E. Porter: innovation and human capital. A qualitative study was conducted with experts in Industry 4.0 that regularly post workers. The results indicate that the COVID-19 pandemic has accelerated the pace of technology adoption (especially Augmented Reality cluster). Industry 4.0 technologies enable companies to reduce the posting of workers. For this purpose, IT skills are now the most important, followed by communication, flexibility, and openness, as well as soft, team and didactic skills. JEL Codes: F23, J61, O33
Community health centers response to the need of dementia care
Authors: Suriastini Ni Wayan , Oktarina Dwi , Sikoki Bondan , Indriati Sunar , Umaroh Rodhiah , Alfah Dani , Lestari Kusmaintan Widya 
Published: March 2023

Background: Dementia prevalence among Indonesian older people is increasing. Community health centers (CHCs) as primary care providers have a responsibility to meet the need of their community. This study aims to measure the response of CHCs to the growing of dementia cases and to investigate factors associated with the knowledge of CHC staff on dementia symptoms in Special Region of Yogyakarta (DI Yogyakarta), Indonesia. Design and methods: This study used a cross-sectional design to obtain census data from 121 CHCs in DI Yogyakarta by interviewing 121 older person program managers of the CHCs via telephone between January and February 2021. Data on knowledge of 10 dementia symptoms, participation in dementia prevention and treatment with dementia, dementia/cognitive screening and coverage as well as factors associated with memory loss and change in mood and behavior were assessed. Data were analyzed using descriptive, bivariate, and multiple logistic regression. Results: The knowledge of dementia symptoms among health workers was low (15%–37%). CHCs had not yet received training on dementia prevention and treatment (58%). Only a few of CHCs treated patient with dementia (36%). Dementia screening and coverage were also low. Engaged in dementia training were more likely to have higher knowledge of dementia symptoms, particularly memory loss and changes in mood and behavior. Conclusions: Dementia training and education are needed to increase knowledge among care providers which would eventually improve CHC response to dementia. Priority should also be in place to support dementia care management.
Cost Analysis and Reimbursement of Weightbearing Computed Tomography
Authors: Alexander Nathaniel B. , Sarfani Shumaila , Strickland Carson D. , Richardson David R. , Murphy G. Andrew , Grear Benjamin J. , Bettin Clayton C. 
Published: March 2023

Background: Weightbearing computed tomography (WBCT) is becoming a valuable tool in the evaluation of foot and ankle pathology. Currently, cost analyses of WBCT scanners in private practice are lacking in the literature. This study evaluated the costs of acquisition, utilization, and reimbursements for a WBCT at a tertiary referral center, information of particular interest to practices considering obtaining such equipment. Methods: All WBCT scans performed at a tertiary referral center over the 55-month period (August 2016 to February 2021) were retrospectively evaluated. Patient demographics, pathology location, etiology, subspecialty of the ordering provider, and whether the study was unilateral or bilateral were collected. Reimbursement was calculated based on payor source as a percentage of Medicare reimbursement for lower extremity CT. The number of total scans performed per month was evaluated to determine revenue generated per month. Results: Over the study period, 1903 scans were performed. An average of 34.6 scans were performed each month. Forty-one providers ordered WBCT scans over the study period. Foot and ankle fellowship-trained orthopaedic surgeons ordered 75.5% of all scans. The most common location of pathology was the ankle, and the most common etiology was trauma. The device was cost neutral at 44.2 months, assuming reimbursement for each study was commensurate with Medicare rates. The device became cost neutral at approximately 29.9 months when calculating reimbursement according to mixed-payor source. Conclusion: As WBCT scan becomes more widely used for evaluation of foot and ankle pathology, practices may be interested in understanding the financial implications of such an investment. To the authors’ knowledge, this study is the only cost-effectiveness analysis of WBCT based in the United States. We found that in a large, multispecialty orthopaedic group, WBCT can be a financially viable asset and a valuable diagnostic tool for a variety of pathologies. Level of Evidence: Level III, diagnostic.