bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Study on Key Effectiveness of Bioaerosol Alarm
Authors: Ruan Xiaohu , Hong Hanhan , Huang Hai , Ren Hao , Tang Hailin 
Published: August 2023

Abstract
A dual-channel bioaerosol monitoring device based on intrinsic fluorescence measurement was built, and biological particle species and concentration were taken as variables to study the detection limits and alarm response time of aerosol particles of different biological warfare agents under the conditions of the same temperature and humidity and different concentrations. The alarm threshold of aerosol particles of different biological warfare agents under different temperature and humidity conditions and the detection ability under the interference of pollen and different disturbers were studied to form preliminary performance indicators and certain evaluation indicators and methods for the biological aerosol monitoring device, so as to demonstrate and evaluate similar aerosol detection in the future. The results showed that for the selected single and mixed strains of bacteria, the results obtained by culture method had a strong linear relationship with the results measured by counter, R2 values were also maintained above 0.88, although the ratio of β=β (culture counting/biological particle counter) of different bacteria was different, but the overall was indeed similar. At last, the anti-interference ability test is carried out, and it is found that it is very sensitive to the selected common disturbers. In general, it shows that the device has high sensitivity, strong accuracy, fast detection time, but weak anti-interference ability.
Simultaneous modeling of maize smallholder farmers’ perceived vulnerability and adaptation to climate change in the eastern Democratic Republic of the Congo
Authors: Mugisho Gilbert M. , Ngalo Luc Murhandikire , Nfuamba Fabrice Lukeba 
Published: August 2023

Abstract
Maize smallholder farmers face a threat from climate change, resulting in decreased agricultural productivity, a disruption in the agricultural calendar, and crop diseases. The purpose of this research was to analyze maize farmers' perceptions of climate change vulnerability and adaptation strategies in the eastern Democratic Republic of the Congo. A structured survey of 210 maize smallholder farmers in South Kivu Province was conducted between October and November 2021. The data were analyzed using simultaneous modeling with the Tobit regression model and structural equations, which demonstrated that demographic and socioeconomic factors influenced farmers' perceptions and adaptation strategies to climate change. The findings revealed that the level of education, size of the field, and activities of the household head had significant effects on climate change perception and adaptation strategies. Farmers' perceptions had a negative (p < 1%) influence on maize smallholder farmers' adaptation to climate change. Common efforts should be made to encourage farmers to feel committed enough to implement climate change adaptation measures that are effective in mitigating or preventing climate change risk.
The Effect of Different Substitutions (Cobalt, Copper, Strontium and Zinc) on the Properties of Akermanite Bioceramic: A Comparative Experimental Study
Authors: Zare Maryam , Khodaei Mohammad , Savabi Omid 
Published: August 2023

Abstract

Bioactive ceramics paly vital role in tissue engineering. One of the most important silicate base bioceramics is akermanite. In this research, the akermanite powder, was synthetized using sol-gel method and the effect of different substituents of Cobalt, Copper, Strontium and Zinc on its properties investigated. Results of Field Emission Scanning Electron Microscope (FESEM) observation and X-ray diffraction analysis (XRD), revealed that the substituents had significant effect on the morphology of powder particles of akermanite, and also the phases of samples. The results of 3-point bending test on sintered samples in cubic form, revealed that substituents affect the bending strength of akermanite, and highest strength were 97 MPa related to the Co- substituted akermanite. After soaking akermanite samples including different substituents in Simulated Body Fluid (SBF) for apatite forming ability measurement, the results of SEM observation, Energy dispersive spectroscopy (EDS) and XRD analysis revealed that all samples had appropriate apatite forming ability and Zn-substituted and unsubstituted akermanite samples had the highest. Also, the result of cell viability measurement via MTT test indicated that the Zn-substituted akermanite had the highest cell viability among all. Noting all results, the Zn-substituted akermanite had the optimum properties for bone tissue engineering.
Current account deficits in selected Emerging Market Economies
Authors: Ndzama Nwabisa 
Published: August 2023

Abstract
The 2022 IMF External Sector Report paints a clear picture of large current account imbalances in the build-up to the global financial crisis (GFC). Many analysts have argued that one fundamental cause of the GFC was global financial imbalances caused by large current account imbalances between the United States as the leading deficit country and China as the leading surplus country. Thus, renewed interest in the current account dynamics emerged following the crisis. This paper gives an insight into current account adjustments using a comparative analysis between selected emerging market economies (Hungary, India, Mexico and South Africa). We answer the following question: Why did some countries with persistent current account deficits experience external crises and similar peers did not? Our analysis shows that the external crisis episodes from the countries that have had large and persistent current account deficits can be associated with sizeable current account deficits, appreciation of real exchange rate, low ratio of exports to GDP and depletion of international reserves.
JEL Codes: F41, F49, F62
Evolutionary and Swarm Intelligence in Optimization of α-Amylase From Bacillus velezensis Sp.
Authors: SASIDHAR BHIMANA , RAVINDRAN SARAVANAN 
Published: August 2023

Abstract
Background
To optimize α-amylase synthesis from fermented broth, this research employed evolutionary and swarm intelligence-based techniques such as genetic algorithm (GA) and particle swarm optimisation (PSO). The nonlinear response surface model (RSM) of α-amylase from Bacillus velezensis sp.was used as the objective function.
Results
In contrast to the enzyme activity, 418.25 U/mL, achieved by the thirteen factors OFAT technique was increased by 2.76 times using GA and PSO optimization with only nine significant parameters. The optimal process parameters predicted using GA and PSO were pH (5.37), temperature (34.18 oC), carbon source (4.12%), nitrogen source (2.04%), K2PO4 (0.34%), MgSO4 (0.2%), NaCl (0.14%), fructose (2.0%), and NaNO3 (0.47%).
Conclusions
The results showed that α-amylase activity was significantly improved with both approaches, with similar predictions of optimized process parameters and α-amylase activity of 1157.2 U/ml. PSO, on the other hand, surpasses GA in terms of optimized α-amylase activity and convergence rate, which might be attributed to its simple structure and efficient memory capabilities. In conclusion, the suggested GA and PSO techniques are thought to be natural and may be used instead of existing gradient-based optimization strategies in downstream enzyme processing.
Revolutionizing Italian Homes: Embracing the Smart Home Era in the Housing Landscape
Authors: Barbera Salvatore La 
Published: August 2023

Abstract
In this paper, we delve into the captivating integration of Italy's rich architectural heritage with the cutting-edge implementation of smart home technologies. Our study embarks on a meticulous journey through Italian history, systematically exploring the seamless fusion of enduring architectural principles and contemporary technological advances. By unraveling the aesthetic paradigms that have defined traditional Italian dwellings, we unveil the methodological process of assimilating novel technologies into the cultural framework. Through compelling case studies, we shed light on the delicate balance achieved between classical design ethos and progressive, environmentally-sustainable technologies, culminating not only in structural transformations but also in the radical redefinition of domestic lifestyles. We meticulously dissect challenges, critically appraise successes, and cogently extrapolate future directions, presenting a visionary outlook on the prospective era of Italian domesticity—a realm where efficiency and elegance harmoniously coexist. Going beyond mere empirical analysis, our scholarly synthesis offers profound insights into the evolution of Italian living spaces, where historical context and modern innovation converge to create environments imbued with functionality, aesthetic grace, and intellectual sophistication. Join us as we witness the Italian renaissance of smart homes, an enthralling journey that epitomizes the symbiotic relationship between tradition and technology in contemporary living.
Improving Behavioral and Social Skills in Children With Down Syndrome Through Parent-Child Interaction Therapy: Effects on Parenting Skills and Stress in Caregivers
Authors: Shahzad Ruhaba 
Published: August 2023

Abstract
• This research employed a new intervention, Parent Child Interactive Therapy, to explore patterns of behavioral and social skills among children with Down syndrome and parenting skills and stress among their caregivers. It aimed to improve these elements to create a more informed environment for Down syndrome children to live in that can decrease their mortality rate in Pakistan. The research was performed as a pre-post quasi-experimental study where different scales were used to tap all the elements and divided behavioral and social skills into further categories. • The experiment took 11 sessions with every participant in the study. However, the treatment was first provided to the experimental group and the effect was seen in two ways: pre and post and in between the groups. The sessions were performed in the playroom of the university clinic where various toys were accessible to the children which strengthened the communication between the child and the parents. • The results were evaluated using version 21 of SPSS which showed that the intervention showed statistical significance on almost every variable involved except the parental stress. This indication shows that parents needed a more intensive intervention for themselves to target their stress and it was not related to their children entirely.
An Empirical Approach in Culinary Fiqh of Coastal Communities: Critical Study of ‘Aysh al-Baḥr
Authors: Mun'im Zainul , Kaya Abdussamet 
Published: August 2023

The lives of fishermen are said to have a profound influence on the lives of coastal towns. Their attitude toward marine resources effects their theological perspective as well. This fact is supported by Kiai Anwar's book ‘Aysh al-Baḥr, which discusses the legal position of consuming numerous aquatic animals. This article seeks to trace the book ‘Aysh al-Baḥr's understanding of culinary fiqh. As an analytical tool, this paper employs a normative approach and the notion of Islamic epistemology pioneered by al-Jābirī and Mulyadhi. This article demonstrates how the epistemology of culinary fiqh in ‘Aysh al-Baḥr employs an empirical approach to determining the legal status of ingesting animals by viewing and direct observing them. Kiai Anwar's background as a fisherman gives him an edge in developing normative and empirical reasons for marine animal laws. This conclusion demonstrates that coastal cultures have an extensive understanding of aquatic animal environments. This article suggests utilizing empirical approaches to derive rules that necessitate direct observation.__________The original draft of this article has been presented at the 20th Annual International Conference on Islamic Studies (AICIS), Surakarta, 2021.
Agricultural wetland utilization based on land cover restoration and water–ecosystem nexus
Authors: Li Jing , Liu Weiwei , Zhang Ying 
Published: August 2023

Abstract

Wetlands, as a special ecological environment, are not only important biodiversity conservation areas but also one of the important agricultural resources. Agriculture plays an irreplaceable role in human society. It is directly related to human survival and development, and is also a part of people's environmental awareness and cultural inheritance. Based on the principles of sustainable development and strengthening environmental protection, people should pay more attention to the development and improvement of agriculture. However, with the advancement of urbanization, the area of wetlands continues to decrease, causing damage to ecosystems and posing a threat to some agricultural production. This article combined the transfer matrix of agricultural wetland utilization, landscape change rate, and landscape pattern index, used RS (Remote Sensing) and GIS (Geographic Information System) technologies to analyze the dynamic changes in agricultural wetland utilization and landscape of Honghu Lake in the Four Lakes region, and explored its changing factors. The results indicated that the construction land area showed an increasing trend in 2016, 2019, and 2022, while the wetland area of rice fields showed a first decreasing and then increasing trend.
Medicinal (Radio) Chemistry: Building Radiopharmaceuticals for the
Future
Authors: Pijeira Martha Sahylí Ortega , Nunes Paulo Sérgio Gonçalves , Chaviano Samila Leon , Diaz Aida M. Abreu , DaSilva Jean N. , Ricci-Junior Eduardo , Alencar Luciana Magalhães Rebelo , Chen Xiaoyuan , Santos-Oliveira Ralph 
Published: August 2023

:
Radiopharmaceuticals are increasingly playing a leading role in diagnosing,
monitoring, and treating disease. In comparison with conventional pharmaceuticals, the
development of radiopharmaceuticals does follow the principles of medicinal chemistry
in the context of imaging-altered physiological processes. The design of a novel radiopharmaceutical
has several steps similar to conventional drug discovery and some particularity.
In the present work, we revisited the insights of medicinal chemistry in the current
radiopharmaceutical development giving examples in oncology, neurology, and cardiology.
In this regard, we overviewed the literature on radiopharmaceutical development to
study overexpressed targets such as prostate-specific membrane antigen and fibroblast activation
protein in cancer; β-amyloid plaques and tau protein in brain disorders; and angiotensin
II type 1 receptor in cardiac disease. The work addresses concepts in the field
of radiopharmacy with a special focus on the potential use of radiopharmaceuticals for
nuclear imaging and theranostics.
Association of Neurokinin-1 Receptor Signaling Pathways with Cancer
Authors: Rodriguez Francisco David , Covenas Rafael 
Published: August 2023

Background:
Numerous biochemical reactions leading to altered cell proliferation
cause tumorigenesis and cancer treatment resistance. The mechanisms implicated include
genetic and epigenetic changes, modified intracellular signaling, and failure of control
mechanisms caused by intrinsic and extrinsic factors alone or combined. No unique
biochemical events are responsible; entangled molecular reactions conduct the resident
cells in a tissue to display uncontrolled growth and abnormal migration. Copious experimental
research supports the etiological responsibility of NK-1R (neurokinin-1 receptor)
activation, alone or cooperating with other mechanisms, in cancer appearance in different
tissues. Consequently, a profound study of this receptor system in the context of malignant
processes is essential to design new treatments targeting NK-1R-deviated activity.

Methods:
This study reviews and discusses recent literature that analyzes the main signaling
pathways influenced by the activation of neurokinin 1 full and truncated receptor
variants. Also, the involvement of NK-1R in cancer development is discussed.

Conclusion:
NK-1R can signal through numerous pathways and cross-talk with other receptor
systems. The participation of override or malfunctioning NK-1R in malignant processes
needs a more precise definition in different types of cancers to apply satisfactory
and effective treatments. A long way has already been traveled: the current disposal of selective
and effective NK-1R antagonists and the capacity to develop new drugs with biased
agonistic properties based on the receptor's structural states with functional significance
opens immediate research action and clinical application.
A Comprehensive Review on Therapeutic Potential of a Natural
Anthraquinone Derivative Emodin in Brain-related Disorders
Authors: Goyal Ahsas , Murti Yogesh , Bhushan Bharat , Chisti Wasim , Solanki Ashutosh 
Published: August 2023

Abstract:
Brain-related disorders are one of the world’s most important and complex health
problems today. These brain-related disorders are responsible for a massive number of morbidities
and death all around the world. However, researchers have devoted a large amount of time to investigating
these diseases and found positive results; nevertheless, there are currently quite a few
medications available to treat them. Emodin (EM), a polyphenol compound, has many health benefits.
It is a biologically active monomer derived from rhubarb root that exhibits anti-inflammation,
anti-oxidation, anticancer, and neuroprotective properties. A series of preclinical trials have shown
EM to have protective benefits against many brain-related diseases. This review has evaluated the
potential of EM as a pharmacological agent for the treatment and management of various brain-related
disorders based on the findings of multiple pre-clinical studies and taking into account the
compound’s therapeutic properties.
Literature-based Comparative Study between Herbal and Synthetic Mucolytics
Authors: Bhuyan Pallabi , Chakraborty Tapash , Ahmed Rakib , Ali Nurul , Ghose Shatabdi 
Published: August 2023

Abstract:
Coughing and sneezing are the body’s reflexes to various acute and chronic respiratory
illnesses like asthma, COPD, lung cancer, etc.

:
Mucus is a sticky, gelatinous material produced by the mucus gland to protect the airways. Mucolytics,
antitussives and expectorants may help in treating hypersecretion of mucin that may lead to
cough, cystic fibrosis, asthma, and COPD. Mucolytics if given along with the drugs like corticosteroids,
albuterol sulphate, and levalbuterol HCl in asthma and for the management of COPD like
corticosteroids and bronchodilators, may help in loosening the viscosity of the mucus and clearing it
out.

:
Mucolytics can be synthetic or herbal in origin and work by one of the three processes, viz. enzymatic
degradation, disulphide bond cleavage and calcium chelation. Mucolytics breaks down mucin
structure and loosen the mucus, helping it to expel out from the body. Some examples of synthetic
mucolytics are Bromhexine and N-acetylcysteine. Herbal mucolytics have traditionally been used
for the treatment of cough by indigenous people of India. Malva sylvestris, Zizyphus vulgaris are
some of the examples of herbal mucolytics.
Nutrition Role in Maintaining Health and Preventing Disease
Authors: Singh Chander , Arti  , Yadav Nikita , Rao Komal , Bharti  , Bansal Nidhi , Archna K.M. 
Published: August 2023

Abstract:
A person's body depends on nutrients, which are the components of food that drive
biological activity. A healthy lifestyle includes having a good diet. All that we eat and drink is what
human bodies are made of and how they are powered. Proteins, lipids, carbs (sugars, dietary filter),
vitamins, and minerals are the several categories that they belong to nutrients, and each one of these
performs a crucial job. Building all body parts, including muscle, bone, teeth, and blood.
Generating energy and maintaining the body's functionality. A complete condition of emotional and
physical well-being is referred to as being "healthy." Optimal nutrition, which supplies all nutrients
at sufficient and suitable levels, is the cornerstone of good health and the forerunner of prevention.
The most significant ongoing environmental influences influencing our growth, development,
functional abilities, and health are the meals we eat and the nutrients they should include. If we
want to successfully reduce the excessive premature morbidity and death from our top killer
diseases-heart disease, cancer, and stroke-we must educate the general population, especially health
professionals, about nutrition. Our lifestyle choices, such as eating, disciplining our health habits,
and exercising, will significantly impact our individual health and lower the costs of our existing
catastrophic medical treatment. The main environmental factors that continue to impact our ability
to grow and develop health are the meals we eat and the nutrients they should include. In this
review, we discuss how nutrients play an important role in preventing our body from disease and
maintaining health.
The Effects of Vitamin D Supplementation on Glycemic Indices, Lipid
Profile and Blood Pressure of Pregnant Women with Vitamin D Deficiency:
A Single Arm Clinical Trial
Authors: Hashemi Seyedeh Razieh , Esmailzadeh Arezoo , Hosseini Mahboobeh Sadat , Abbaszadeh Sepideh , Taghdir Maryam , Esmailzadeh Simindokht , Babashamsi Tahereh , Nahani Saeideh 
Published: August 2023

Introduction:
Vitamin D Deficiency (VDD) is a global problem among pregnant women in
many populations. There is an association between VDD and some pregnancy outcomes, as well as
gestational diabetes mellitus (GDM) and pre-eclampsia. We aimed to evaluate the effect of vitamin D
supplementation on metabolic status (Fasting Blood Sugar (FBS), insulin, Homeostasis model of assessment-insulin resistance (HOMA-IR) and lipid profile) and blood pressure (BP) among pregnant
women with VDD.

Methods:
A clinical trial was carried out on 30 pregnant women with VDD referring to the Gynecology & Obstetrics Clinic of Baqiyatallah Hospital, Tehran, Iran. The present study had two phases of
vitamin D3 supplementation (50000 IU / week for 12 weeks and then 50000 IU / month for three
months). Serum total cholesterol, triglyceride, Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), 25-hydroxyvitamin D (25(OH) D) level, insulin, Fasting Blood Sugar (FBS) and both
systolic and diastolic blood pressure were measured. Homeostasis model of assessment-insulin resistance (HOMA-IR) was also determined.

Results:
The results showed that mean levels of Insulin (p=0.010), HOMA-IR (p=0.020), 25(OH) D
level (p=0.001), cholesterol (p=0.001), triglyceride (p=0.001) and LDL (p=0.001) significantly increases during study period. However, Diastolic and systolic blood pressure, FBS, and HDL levels did
not change significantly over time.

Conclusion:
The results of this investigation showed that weekly and monthly vitamin D3 supplementation in pregnant women with VDD had beneficial effects on glycemic status, lipid profile and blood
pressure.