bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of early dose increase of evocalcet for intractable hypercalcemia caused by parathyroid carcinoma
Authors: Morishita Azusa , Hozumi Yasuo , Ishii Hiroaki , Hokazono Yukio , Manuel Yosei Kikuchi Clovis , Shimasaki Megumi , Itaya Mikiko , Oura Masaharu , Kuriki Ken , Hishida Akira , Seki George 
Published: January 2023

Summary
Hypercalcemia due to parathyroid carcinoma (PC) is safely and quickly controlled with rapidly increasing evocalcet doses. Most parathyroid carcinomas are detected because of hypercalcemia due to primary hyperparathyroidism (PHPT). Hypercalcemia becomes more severe in patients with PC than those with parathyroid adenoma or hyperplasia. Hypercalcemia often causes renal dysfunction, gastrointestinal symptoms, and psychiatric symptoms. Consequently, the serum calcium level needs to be promptly corrected. Here, we report a case of PC with remarkably persistent hypercalcemia, which we safely and quickly controlled with rapidly increasing evocalcet doses. A 77-year-old female presented with renal dysfunction. Her serum calcium (Ca) and intact parathyroid hormone serum levels were 13.9 mg/dL and 1.074 pg/mL, respectively. Her renal function worsened because of hypercalcemia due to PHPT. Technetium-99 m methoxy-isobutyl-isonitrile parathyroid scintigraphic examination revealed an accumulation below the right thyroid lobe. CT examination showed a 35-mm mass. Hypercalcemia needed to be immediately corrected because of the patient’s worsening renal function. Evocalcet treatment at a gradually increasing dose of up to 20 mg over 3 weeks allowed her serum Ca level to be maintained below 11 mg/dL. Only mild nausea was observed at the beginning of the treatment. The mass was suspected as PC because the hypercalcemia was refractory to high-dose evocalcet. The patient was treated with parathyroidectomy and ipsilateral thyroidectomy. PC was diagnosed based on the pathological findings of capsular and venous invasion. The patient’s renal function improved and surgery could be safely performed by promptly correcting hypercalcemia.

Learning points

Hypercalcemia due to parathyroid carcinoma (PC) is often more severe than that caused by parathyroid adenoma or hyperplasia.

PC is a rare disease, but it should be considered if the patient has intractable hypercalcemia due to primary hyperparathyroidism (PHPT).

Evocalcet, which is used to treat hypercalcemia due to PHPT, does not interact with P450 (CYP) and causes few side effects.

Complications, including renal dysfunction, were improved and the surgery could be safely performed by promptly correcting hypercalcemia.

PC has a high recurrence rate. En-block excision is necessary when PC is suspected.
Pyogenic spondylitis due to Streptococcus agalactiae with paraspinal abscess and vertebral destruction in a diabetic patient: time course of imagings
Authors: Kobayashi Tomoko , Iwata Takuya , Handa Katsunari , Arima Hiroshi 
Published: January 2023

Summary
A 76-year-old female with type 2 diabetes mellitus presented with hematuria, low back pain, and intermittent fever for 7 days. She was admitted to our hospital and diagnosed with Streptococcus agalactiae (GBS) bacteremia. CT showed an air density within the right iliopsoas muscle, and an MRI of the spine revealed hyperintensity in the right half of the L1–L2 intervertebral disk, leading to the diagnosis of a paraspinal abscess and L1–L2 pyogenic spondylitis. Antibiotic therapy was started and the clinical symptoms, as well as serologic biomarkers and radiologic images of the paraspinal abscess, were improved. The therapy was stopped on day 72 despite vertebral destruction progression. Vertebral endplate ossification was observed on day 108, and further bone formation was noted on day 177. Our case study with radiologic findings over 6 months demonstrated how bone destruction with pyogenic spondylitis, which had been treated with antibiotic therapy, improved after cessation of antibiotics.

Learning points

Although GBS is a rare cause of spondylitis, diabetic mellitus is a risk factor for the development of invasive GBS infections, especially under poor glycemic control.

Bone destruction of pyogenic spondylitis can improve after discontinuation of antibiotic therapy.

It may be important to decide the period of antibiotic therapy based on clinical conditions, serologic biomarkers, and soft tissue findings rather than bone findings.

When elderly diabetic patients present with back pain and fever, spondylitis should be considered in the differential diagnosis to avoid potential diagnostic delays or misdiagnosis.
PENGGUNAAN AYAT-AYAT AL-QUR’AN DALAM SASTRA MELAYU (KAJIAN HERMENEUTIK TERHADAP KARYA SASTRA HAMZAH FANSURI)
Authors: Rosalina Arin Rinda 
Published: January 2023

Abstrak: Artikel ini meneliti khazanah karya sastra Hamzah Fansuri yang menggunakan ayat-ayat Al-Qur’an dengan perspektif tafsir esoterik (batiniah). Penelitian dilatarbelakangi oleh fakta menarik terkait fragmen ayat Al-Qur’an dalam karya sastra Hamzah Fansuri yang saat ini masih sangat terabaikan oleh dunia penelitian akademik terutamanya kajian tafsir Al-Qur’an. Unsur-unsur yang diuraikan antara lain karakteristik karya sastra Hamzah Fansuri, penggunaan ayat-ayat Al-Qur’an di dalamnya, dan implikasi penggunaan ayat-ayat Al-Qur’an terhadap kedalaman pemaknaan. Metode analisis data dalam kajian ini adalah deskriptif-kualitatif atau pendekatan yang mempelajari spekulasi filosofis (perenungan) dengan menyelipkan fragmen ayat Al-Qur’an di bait-bait puisinya. Penelitian ini menunjukkan bahwa fragmen ayat Al-Qur’an dalam karya sastra Hamzah Fansuri yang memberikan kedalaman pemaknaan dipengaruhi pemikiran tasawuf wujuddiyyah (wujud Tuhan). Penelitian juga menunjukkan karya sastra Hamzah Fansuri mampu menularkan pengetahuan dan kesadaran beragama. Kata Kunci : Bait-bait puisi Hamzah Fansuri, Fragmen ayat Al-Qur’an, Tafsir esoterik Abstract: This article examines the treasures of Hamzah Fansuri's literary works that use verses of the Qur'an with an esoteric (batiniah) interpretation perspective. The research is motivated by interesting facts related to fragments of Al-Qur'an verses in Hamzah Fansuri's literary works which are currently still very neglected by the world of academic research, especially the study of Al-Qur'an interpretation. The elements described include the characteristics of Hamzah Fansuri's literary work, the use of the verses of the Qur'an in it, and the implications of the use of the verses of the Qur'an on the depth of meaning. The data analysis method in this study is descriptive-qualitative or an approach that studies philosophical speculation (contemplation) by inserting fragments of Al-Qur'an verses in the verses of the poem. This study shows that the fragments of Al-Qur'an verses in Hamzah Fansuri's literary works that provide depth of meaning are influenced by the thought of SufismManifestdiyyah (the form of God). Research also shows that Hamzah Fansuri's literary works are able to transmit knowledge and religious awareness. Keywords: Hamzah Fansuri poetry verses, fragments of Al-Qur'an verses, esoteric interpretation
REPRESENTASI KEARIFAN LOKAL DALAM KEPEMIMPINAN PADA CERITA RAKYAT SASAKALA GUNUNG TAMPOMAS
Authors: Sukmana Ece 
Published: January 2023

Penelitian ini memaparkan nilai kearifan lokal dalam kepemimpinan dalam cerita rakyat Sasakala Gunung Tampomas. Cerita rakyat Sasakala Gunung Tampomas dalam penelitian ini ditelaah untuk memeriksa nilai kearifan lokal yang merepresentasikan kepemimpinan masyarakat Sumedang. Dalam penelitian ini, metode yang digunakan adalah metode kualitatif. Penelitian ini menganalisis objek menggunakan teori analisis naratif Vladimir Propp untuk mengupas struktur cerita dan fungsi cerita. Semiotika Roland Barthes untuk mengupas nilai-nilai kearifan lokal berdasarkan tanda dan makna, kemudian menggunakan teori Representasi Stuart Hall untuk melihat representasi kepemimpinan. Hasil analisis dari penelitian ini, yaitu: 1) terdapat delapan fungsi cerita dan tindakan setiap karakter mengartikulasikan nilai-nilai kepemimpinan, 2) tanda-tanda dalam Sasakala Gunung Tampomas berkaitan dengan nilai kepemimpinan menurut kearifan lokal; dan 3) kebijakan yang dikeluarkan pemimpin Sumedang dalam sejarah kepemimpinan ditampilkan dalam cerita rakyat Sasakala Gunung Tampomas.
Mapping Hate Speech on Social Media: Religion-State Relations in Indonesia
Authors: Sazali Hasan , SM Umar Abdur Rahim , Marta Rustono Farady , Gatcho Al Ryanne Gabonada 
Published: January 2023

The presence of the development of communication and information technology has also resulted in changes in all dimensions of human life, including of social interaction that have turned into digital interactions. Social media has also become a public sphere for people to express all expressions, opinions, ideas and feelings, including conveying hate speech. In Indonesia, there are many forms of hate speech, one of which leads to issues of racism, religious and state sentiment. This study tries to map the issue of hate speech that has relations between religion and the state on social media. This study is a descriptive qualitative study by taking data from Social Media Analysts using a query for hate speech words that have a relationship between religion and the state that are popular in Indonesia, namely the words Kadrun and Cebong. The results show that there are around 52,290 thousand mentions containing words of hate speech using the word kadrun and 25,290 thousand mentions of hate speech using the word cebong with the underlying issues involved. AbstrakHadirnya perkembangan teknologi komunikasi dan informasi turut mengakibatkan adanya perubahan dalam segala dimensi kehidupan manusia termasuk dalam dimensi interaksi sosial yang berubah menjadi interaksi digital. Media sosial pun menjadi ruang baru bagi masyarakat dalam menyampaikan segala ekspresi, pendapat, gagasan serta perasaannya termasuk dalam menyampaikan ujaran yang berisi kebencian. Di Indonesia ada banyak sekali bentuk ujaran kebencian yang salah satunya mengarah pada isu rasisme, sentimen agama dan negara. Penelitian ini coba memetakan isu ujaran kebencian yang memiliki relasi agama dan negara yang ada dimedia sosial. Penelitian ini merupakan penelitian kualitatif deskriptif dengan mengambil data dari Social Media Analyst menggunakan query kata ujaran kebencian yang memiliki relasi antara agama dan negara yang populer di Indoensia yaitu kata Kadrun dan Cebong. Hasil menunjukkan bahwa terdapat sekitar 52.290 ribu mentions yang berisi kata-kata ujaran kebencian menggunakan kata kadrun dan 25.290 ribu mentions ujaran kebencian menggunakan kata cebong dengan isu-isu yang ikut serta melatar belakanginya.
Myocardial strain parameters and autonomic balance in various variants of the postinfarction course in patients receiving high-dose atorvastatin therapy
Authors: Oleinikov V. E. , Golubeva A. V. , Barmenkova Yu. A. , Kulyutsin A. V. , Burko N. V. , Lukyanova M. V. , Donetskaya N. A. 
Published: January 2023

Aim. To study parameters of left ventricular (LV) strain and heart rate variability (HRV) in patients with ST-segment elevation myocardial infarction (STEMI) in various variants of postinfarction receiving high-dose atorvastatin therapy.Material and methods. The study included 96 patients with STEMI. All patients underwent two-dimensional speckle tracking echocardiography and 24-hour electrocardiographic monitoring with HRV analysis. The included individuals were divided into groups without pathological LV remodeling (R (-), n=57) and with pathological post-infarction LV remodeling (R (+), n=39), the criterion for which was an increase in end-diastolic and/or end-systolic volume >20% and >15%, respectively. Further, depending on the achievement of target low-density lipoprotein cholesterol (LDL-C) (1,5 mmol/l and/or a decrease of more than 50%), the following subgroups were identified: 17 (43,6%) people, who reached target LDL-C levels (group 1), 22 (56,4%) patients, who did not reach target LDL-C levels (group 2). Similar subgroups were identified in the R (-) group as follows: 28 (49,1%) people, who reached target LDL-C levels (group 3) and 29 (50,9%) people, who did not reach target LDL-C levels (group 4).Results. Starting from the 12th week of follow-up, worsening of global longitudinal (GLS), circumferential (GCS), and radial (GRS) strain (p<0,01) was registered in group 2. In group 1, worsening of these parameters was registered only by the 48th week (p<0,01). In group 3, an increase in GLS was revealed by the 48th week (p=0,001), GCS and GRS — by the 12th week (p<0,05). In group 4, favorable changes were observed only in GLS and GCS by the 48th week (p<0,01). A significant change in HRV parameters was observed in group 3. By the 48th week, there was an increase in temporal indicators (SDNN, SDNNi, SDANN, RMSSD, pNN50) (p<0,0001) and total spectrum power (p=0,0001) due to an increase in all frequency indicators (p<0,001), while the index of autonomic balance L/H decreased by 33% (p=0,002). In group 4, only SDNN, SDANN and pNN50 (p<0,05), as well as the total spectrum power (p=0,001) increased, but no change in frequencies. According to intergroup analysis in the acute period of STEMI, group 4 patients had higher HRV than in group 3 (p<0,05).Conclusion. High-dose atorvastatin therapy improves LV strain characteristics and autonomic balance during the rehabilitation period after STEMI.
Peluang Faith-based Marketing Komunikasi dalam Promosi Produk Cryptocurrency di Indonesia
Authors: Ekaputri Sarah Derma , Karolina Cut Meutia 
Published: January 2023

Berbagai pendapat pro dan kontra mengenai halal atau haram crypto currency menjadi salah satu pembicaraan yang banyak dibahas masyarakat siber. Namun, di tengah keributan tersebut, sebuah produk crypto currency melakukan promosi produknya yang tak luput dari penggunaan simbol-simbol agama (Faith based Marketing). Penelitian ini bertujuan untuk mengetahui bagaimana investasi crypto yang dipromosikan dengan pendekatan Faith based Marketing dipandang oleh masyarakat siber di Indonesia dengan menggunakan studi kualitatif netnografi. Teori dan konsep yang digunakan pada penelitian ini meliputi Faith-based Marketing (FbM), teori participatory culture, dan kredibilitas sumber. Hasil penelitian menunjukkan bahwa kategori respons masyarakat siber mengenai topik dengan pendekatan FbM ini terdiri dari empat kategori, yaitu (1) Ketidakpercayaan pada praktik faith-based Marketing; (2) Perdebatan Halal/Haram Produk; (3) Kredibilitas komunikator dan produk; dan (4) ketidakpedulian. Temuan ini dapat menjadi pertimbangan dalam perencanaan pemasaran produk, terutama dengan pendekatan FbM. Temuan unik pada penelitian ini berkaitan dengan FbM yang pada kenyataannya belum tentu mendapat respon baik pada setiap praktiknya. Penelitian lanjutan yang disarankan yaitu mengembangkan topik penelitian yang sama dengan menggunakan strategi lainnya seperti studi kasus, fenomenologi dan dapat pula diuji secara kuantitatif untuk mengukur efektivitas pemasaran cryptocurrency dengan pendekatan FbM.
TWITTER SEBAGAI MEDIA KOMUNIKASI KRISIS PEMIMPIN PEMERINTAHAN DI INDONESIA (STUDI GELOMBANG COVID-19 VARIAN DELTA DAN OMICRON)
Authors: Priyansyah Rifki Nur , Wibowo Kunto Adi , Fuady Ikhsan 
Published: January 2023

Juli 2021, gelombang Delta menerpa Indonesia menjadikan negara dengan kasus harian COVID-19 terbanyak di dunia. Angka tersebut terlampaui pada Februari 2022 dengan kasus harian 55.000 orang. Cuitan Twitter presiden dan gubernur (Jawa Barat, D.K.I. Jakarta, Jawa Tengah, dan Jawa Timur) selama dua gelombang COVID-19 dikaji dengan menerapkan metode analisis isi untuk melihat perbedaan sifat cuitan antar satu akun dan antara gelombang Delta dengan Omicron. Cuitan diklasifikasikan berdasarkan gaya (request, first-person & second-person), strategi (information, bonding, & action), suasana (optimis, pesimis, netral, & nihil), dan tema (COVID-19, ekologi, ekonomi, politik pemerintahan, sosial budaya, sains). Dari 760 cuitan, 27 di antaranya dianalisis karena tidak memenuhi standar kalimat yang layak. Uji Chi-Square menunjukkan, Jokowi didominasi oleh pesan first-person, Ganjar didominasi pesan second-person, Anies didominasi pesan bonding, dan Khofifah didominasi pesan COVID-19 dibandingkan bukan COVID-19. Dari sisi jenis gelombang, membuktikan bahwa pesan request, first-person, aksi, dan COVID-19 berkurang secara signifikan saat gelombang Omicron dibandingkan gelombang Delta. Penggunaan cuitan optimis cenderung konsisten, baik di antara akun maupun gelombang. Potensi Twitter dalam penggunaan pesan bonding dan aksi sudah digunakan oleh kelima pemimpin. Perbedaan konsentrasi pesan COVID-19 dan aksi tetap perlu dilakukan dengan pertimbangan ahli terkait, terutama dalam kaitannya dengan kesehatan fisik dan mental masyarakat.
BUDAYA PARTISIPASI DAN RESISTENSI KOMUNITAS KEAGAMAAN DI MEDIA SOSIAL
Authors: Gafallo M. Fadhil Yarda , Iriansyah Adibrata , Adiansyah  
Published: January 2023

Isu keagamaan merupakan isu yang sering diperbincangkan di tengah masyarakat sosial religius seperti Indonesia. Tanggal 29 Juli 2022 Kementerian Agama Republik Indonesia melakukan Telekonferensi Sidang Isbat pada akun instagram @kemenag_ri. Hasil Sidang Isbat mendapat penolakan langsung oleh pengguna instagram yang termuat dalam kolom komentar. Penelitian ini berfokus pada keterhubungan budaya partisipasi dan ragam penolakan yang terjadi di media sosial instagram. Penelitian ini menggunakan metode netnografi sebagai upaya mendalami interaksi yang terbangun pada komunitas keagamaan. Pengumpulan data dilakukan dengan menggunakan teknik observasi daring pada arsip komentar. Dari total 663 komentar didapatkan 42 pernyataan penolakan yang selanjutnya dianalisis menggunakan pendekatan analisis netnografi. Hasil penelitian ini menemukan aktivitas pengguna instagram menciptakan budaya partisipasi dalam menyikapi tayangan Telekonferensi Sidang Isbat pada akun instagram @kemanag_ri. Keberagaman pengguna instagram dan ragam bentuk aktivitas partisipasi menghasilkan sikap penolakan. Adapun sikap penolakan dilatar belakangi empat aspek. Pertama, aspek agama. Kedua, aspek sosial. Ketiga aspek politik. Keempat, aspek kebijakan.
Digital transformation and social responsibility: pragmatism or the search for balance
Authors: Izmailova M. A. 
Published: January 2023

Purpose: the article defines modern approaches to establishing a balance between digital transformation and the social responsibility of the state and business based on identifying trends and principles for introducing digital technologies into human life, taking into account the priority of social responsibility.Methods: the study is based on a systematic approach to the digital transformation of society. Within the framework of this approach, the use of the achievements of scientific and technological progress is considered: in public administration – for the purpose of breakthrough development of the country and the interconnected solution of socio-economic problems; in the business sphere – to improve the quality of economic activity and strengthen competitive benefits.Results: a review of the current state of the digitalizing society, the demand for digital services and satisfaction with the quality of their receipt, the readiness of Russian regions to provide electronic public services. The trends of digital transformation of public administration and the stages of evolution of digital maturity of the state are revealed. It is emphasized that the successful solution of the issues of the digital agenda by the state becomes a stimulating factor in the digital development of business structures. The analysis of digital trends in the business environment has shown their conjugacy with the digitalization of public administration in the presence of a number of differences. The key role of company management in promoting the ideology of digital transformation is noted. Since the use of digital technologies, along with positive effects, can pose a threat to human security, the preservation of his rights and freedom, it becomes necessary to use the concept of social responsibility in carrying out digital transformations of society. The principles of social responsibility in carrying out digital transformations are defined.Conclusions and Relevance: the processes of digital transformation have firmly entered into all spheres of society. Despite the technological nature, digital development should take place in the logic of a humanistic approach. It is based on the principles of morality, recognition of the inviolability of human rights, with the emphasis on the importance of social responsibility of all actors of digital transformation. At the same time, Russia should build its own model of digital transformation based on respect for dignity, freedom and human rights guaranteed by the Constitution.
Index approach to the assessment of the formation of human capital of the enterprise
Authors: Flek M. B. , Ugnich E. A. 
Published: January 2023

Purpose: of the article is to develop a methodology for assessing the formation of an enterprise human capital, which is based on the calculation of indices of formal and informal learning of its employees.Methods: this article is based on the key provisions of the theory of human capital. The focus of this research is the specific enterprise human capital. The questionnaire method was used, which allowed assessing the development of the enterprise human capital based on the opinions of its direct carriers – employees representing different professional groups. The index method was used. Based on the calculation of the indices of formal and informal learning, the composite indices of the formation of human capital were determined, reflecting the assessment of the actual learning of employees and the desired state in which they feel the need. Visualization of the obtained results is presented in the form of theperception map.Results: the article presents an improved methodology for assessing the formation of human capital of an enterprise. The assessment of the formation of human capital of various professional groups of employees of the enterprise is carried out. The conducted research has shown that the need for formal and informal learning in various professional groups is differentiated. The essence of the author's position is that one of the most important tasks of the enterprise for the development of human capital is the organization of formal and informal learning of its employees in accordance with the current and future needs of the enterprise itself. The prospects for the development of the enterprise human capital are seen in the development of its vocational education ecosystem by strengthening relationships with educational organizations and other providers of new progressive knowledge, and also by strengthening the relationship between formal and informal learning.Conclusions and Relevance: the approach to the assessment of the human capital development of an enterprise considered in the article allows us to give practical recommendations on optimizing the organization of learning of the enterprise employees. The results of the study can be used by the professional community, including business leaders, to form a strategy for the development of human capital.