bluuebunny/crossref_metadata_2025_split huggingface dataset:
La plateformisation comme idéal participatif : vers une démocratisation de la démocratie ?
Authors: Theviot Anaïs 
Published: January 2023

Dans le contexte de discours critiques récurrents envers les partis politiques, des expérimentations se mettent en place, lors des élections présidentielles et législatives de 2017, afin de dépasser la forme partisane et de proposer d’autres alternatives à la sélection des candidats, en s’appuyant sur une plateforme. Celle-ci est en effet centrale dans nos deux cas d’étude – Ma Voix et LaPrimaire.org – car c’est par le truchement de la technique que s’organise la refonte des institutions. L’étude de ces initiatives repose sur l’analyse du design et du contenu des plateformes, ainsi que sur des entretiens et récits de vie avec les concepteurs, militants et usagers. L’analyse met au jour des visions plurielles de la démocratie et de son renouvellement : d’un côté, une vision capacitaire fondée sur l’individu compétent et, de l’autre, une conception basée sur un collectif de profanes anonymes et l’apprentissage. L’objectif d’ouvrir la démocratie – au sens d’aller chercher des internautes-candidats peu dotés socialement – n’est pas rempli : ceux qui osent s’inscrire via la plateforme sont en grande majorité des hommes, de gauche, ayant fait des études supérieures et habitant dans de grandes villes.
Les femmes, le nom, Freud
Authors: Prado de Oliveira Luiz Eduardo , Schmitt Hélène 
Published: January 2023

Je pars d’une constatation et d’une surprise : dans le judaïsme c’est la mère qui transmet la qualité de juif, mais c’est le père qui donne le nom. À partir de là, je m’intéresse à l’histoire de Freud, à ses relations à ses enfants, kinder , en particulier à ses filles, et à l’obligation du petit-fils. Ce qui nous amène à la « famille symbiotique », selon ce qu’écrit Freud à Eitingon.
L-carvone attenuates myocardial injury and dyslipidemia in rats with isoproterenolinduced cardiac hypertrophy
Authors: Nagarajan Anitha , Doss Victor Arokia 
Published: January 2023

Objective:
To explore the therapeutic efficacy of L-carvone from Mentha spicataL. leaf extracts against isoproterenol-induced cardiac hypertrophy in rats.

Methods:
Isoproterenol (5 mg/kg) was injected intraperitoneally into rats for one month to induce cardiac hypertrophy. L-carvone (25 and 100 mg/kg) was administered orally to treat cardiac hypertrophy. The cardioprotective activity of L-carvone was evaluated by electrocardiogram, histopathological analysis as well as determination of biochemical parameters and enzymatic markers.

Results:

L-carvone from Mentha spicata L. at 25 and 100 mg/kg ameliorated isoproterenol-induced cardiac hypertrophy, as evidenced by reduced QRS interval on electrocardiogram, and decreased heart weight and heart index. In addition, both doses of L-carvone markedly lowered the levels of glucose, total protein, low-density lipoprotein cholesterol, aspartate transaminase, alanine transaminase, lactate dehydrogenase, creatine kinase MB, troponin-I, N-terminal pro-B type natriuretic peptide and triglycerides while increasing high-density lipoprotein cholesterol and lipase level (P<0.05). Moreover, L-carvone alleviated contraction band necrosis, and reorganized the myofibrils with normal striations and myocytes as well as normal nuclei in cardiac histoarchitecture of rats with isoproterenol-induced cardiac hypertrophy.

Conclusions:

L-carvone from Mentha spicata L. leaf extract can restore abnormal cardiac function and may be further explored as a therapeutic agent against the deleterious effects of cardiac hypertrophy after further evaluation.
Molluscicidal effect of green synthesized silver nanoparticles using Azadirachta indica on Biomphalaria alexandrina snails and Schistosoma mansoni cercariae
Authors: Younis Salwa S. , Abou-El-Naga Iman F. , Radwan Khaled H. 
Published: January 2023

Objective:
To assess the molluscicidal effect of the eco-friendly green synthesized neem silver nanoparticles (neem-Ag NPs) against Biomphalaria alexandrina, the snail intermediate host for Schistosoma mansoni, and their cercaricidal potential.

Methods:
Methanol extracts from neem fruits were used for green synthesis of neem-Ag NPs. The neem-Ag NPs were characterized using UV-visible absorption spectra, dynamic laser light scattering technique, and transmission electron microscopy. The potential molluscicidal effect against adult and juvenile Biomphalaria alexandrina and the effect of the sub-lethal concentration on hatching of snail eggs and Schistosoma mansoni cercariae were evaluated.

Results:
The surface plasmon resonance of neem-Ag NPs showed a sharp absorption peak at λmax = 518 nm together with multiple peaks. The hydrodynamic diameter was (77.15±34.53) nm, the polydispersity index (0.338±0.000) and the zeta-potential −14.07 mV. Moreover, transmission electron microscopy showed that the average size of the nanoparticles was (27±2) nm. Agglomeration was evident and a light-colored capping layer could be seen coating the nanoparticles. Juvenile snails (LC50: 0.83 ppm) were more susceptible to neem-Ag NPs than adults (LC50: 1.07 ppm). In addition, neem-Ag NPs and neem at LC50 concentrations inhibited the egg-hatching of snails and showed cercaricidal activity in a time-dependent manner.

Conclusions:
Neem-Ag NPs have lethal activities against Biomphalaria alexandrina snails and their eggs, as well as Schistosoma mansoni cercariae. Hence, neem-Ag NPs could be a potential agent to control schistosomiasis.
Anti-leishmanial, immunomodulatory and anti-oxidative activity of quercetin against cutaneous leishmaniasis caused by Leishmania major
Authors: Oryan Ahmad , Bemani Effat , Bahrami Somayeh 
Published: January 2023

Objective:
To evaluate the in vitro and in vivo efficacy of quercetin and its immunomodulatory and anti-oxidative activity against Leishmania major (L. major).

Methods:

L. major promastigotes and amastigotes were incubated with different concentrations of quercetin to estimate EC50. For in vivo study, the base of tails of mice was infected with L. major. After developing ulcers in the inoculation site, mice were treated with 50 mg/kg quercetin orally for 28 consecutive days. The wound-healing potential of quercetin was evaluated by histopathological analysis of tissue sections stained by hematoxylin and eosin as well as Masson's trichrome. In addition, the levels of tumor necrosis factor-α, interleukin-6, malondialdehyde, and adiponectin, the ferric reducing ability of plasma, as well as superoxide dismutase and glutathione peroxidase activities were measured.

Results:
The EC50 values of quercetin against L. major promastigotes and intracellular amastigotes were 0.27 and 0.85 μM, respectively. Histopathological analysis showed that fewer inflammatory cells, more fibroblasts, and more collagen deposition were observed in tissue sections of quercetin-treated mice. In addition, treatment with quercetin markedly increased glutathione peroxidase activity, the ferric reducing ability of plasma and adiponectin levels while decreasing malondialdehyde, interleukin-6, and tumor necrosis factor-α levels.

Conclusions:
Quercetin shows anti-leishmanial activity, immunomodulatory, anti-oxidative, and anti-inflammatory effects. Therefore, it may be further explored as an effective drug in treating leishmaniasis.
Grafted Tubularised Incised Plate: A Right Option in the Management of Failed Mid-Penile and Distal Hypospadias
Authors: Nerli Rajendra B. , Chandra Shoubhik , Rai Shreyas , Dixit Neeraj S. 
Published: January 2023

Introduction:
Hypospadias is a common congenital anomaly of the urogenital system. The goal of the initial repair is to correct any curvature, ensuring that the penis is straight, allowing for successful intercourse, to create a functional neourethra to direct the urinary stream in a forward direction and to produce a cosmetically normal-appearing penis with a slit-like meatus at the tip of the glans. Failures and complications do occur. Failed hypospadias repair is often associated with penile skin loss or deficient local tissue, which leaves the penis short, scarred and hypovascular. Repair of a failed hypospadias surgery represents one of the most challenging and difficult tasks. We retrospectively evaluated our series of children who underwent reoperative grafted tubularised incised plate (G-TIP) repair for a mid-penile or distal penile hypospadias.

Materials and Methods:
With permission obtained from the university/institutional ethics committee, we retrospectively reviewed the inpatient and outpatient records of all children ≤18 years of age who underwent a reoperative G-TIP hypospadias repair.

Results:
During the study period, a total of 22 children (mean age: 6.8 years) underwent reoperative G-TIP repair. The mean number of previous repairs was 1.36. Nine (40.9%) of the children had persisting chordee. Complications were noted in five (22.7%) children.

Conclusion:
G-TIP is a good option in the management of mid-penile or distal penile failed hypospadias repairs. Although complications are noted, they are easily manageable.
Knowledge and Awareness of Aetiological and Risk Factors as Determinants of Health-Seeking Pattern of Parents of Children with Epistaxis in a Tertiary Health Institution: A 7-Year Prospective Study
Authors: Aremu Shuaib Kayode 
Published: January 2023

Aim:
This prospective study aimed to assess the knowledge and awareness of aetiological and risk factors as determinants of the health-seeking pattern of parents of children with epistaxis in a tertiary health institution.

Materials and Methods:
This was a 7-year cross-sectional prospective study where copies of the questionnaire were distributed to consenting parents whose children presented to our institution with epistaxis between January 2015 and December 2021. A total of 570 parents were enrolled in the study in the research time period.

Results:
Out of 570 patients, majority (39%) were aged between 11 and 15 years, followed by 35% aged between 6 and 10 years, 17% aged between 1 and 5 years and 11% aged between 16 and 18 years. Three hundred and eighty (66.67%) were male and 190 (33.33%) were female. Two hundred and ninety-five (51.75%) patients had primary education, followed by 189 (33.16%) patients with secondary education and 86 (15.09%) patients with preschool education. Three hundred and seventy-three (65.44%) patients had anterior bleeding and 107 (18.77%) patients had posterior bleeding while 90 (15.79%) patients had both anterior and posterior bleeding. The majority of the parents, 399 (70%), were aware about the epistaxis while 171 (30%) parents were unaware about the epistaxis.

Conclusion:
A significant number of parents are unaware of the epistaxis and also unaware of the various aetiological and risk factors of the epistaxis and these issues need a more nuanced analysis in light of Africa’s rich cultural diversity.
Effect of predialysis fluid overload on sleep quality in hemodialysis patients
Authors: Hussein Hussein S. , Abdelaziz Haitham E. , Ahmed Mohamed A. , Emara Ahmed A. 
Published: January 2023

Background
Sleep disorders are common among end-stage renal disease patients undergoing hemodialysis (HD). The etiology of sleep disorders in these patients is known to be multifactorial. However, the role of hydration status in sleep disorders in HD patients is not well studied. Therefore, our aim was to study the effect of predialysis fluid overload on sleep quality in HD patients.

Patients and methods
This cross-sectional study included 100 prevalent HD patients from the HD unit of El Sahel Teaching Hospital. Fluid status and fluid compartments [total body water), extracellular water (ECW),and overhydration (OH) index] were analyzed by a portable whole-body bioimpedance spectroscopy (body composition monitor) before a mid-week dialysis session. OH was defined as OH/ECW% more than or equal to 15%. HD patients were then classified into two groups: group 1 (normohydrated) and group 2 (overhydrated) according to the relative OH index (OH/ECW%). Sleep quality was assessed in all patients by the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Patients with concurrent diagnosis of either obstructive sleep apnea or psychiatric disorder and patients on any medications that affect the sleep pattern were excluded.

Results
Our study included 100 HD patients (49 male, 51 female; mean age, 49.3 ± 11); 42 (42%) patients had OH (i.e. group 2). Poor sleep quality (defined as PSQI score ≥5) was reported in 57% (n=57) of HD patients included in our study. Poor sleep quality was significantly higher in the HD patients with OH (group 2). Total PSQI scores were significantly higher in overhydrated patients (group 2) compared with normohydrated patients (group 1) (7.92 ± 3.32 vs. 4.83 ± 2.27, P≤0.001). The component scores 1, 2, 3, 4, 6, and 7 of the PSQI showed significant higher values (i.e. poor sleep quality) in overhydrated patients (group 2). Moreover, there was significant positive correlation between total PSQI score both of OH (r=0.259, P=0.009) and OH index (OH/ECW%) (r=0.283, P=0.004) in all HD patients included in the study.

Conclusion
We may conclude from our study that sleep disorders are prevalent in HD patients. Predialysis fluid overload in HD patients may be associated significantly with poor sleep quality.
Serum immunoglobulin G as a predictive marker of early renal affection in type-2 diabetic patients
Authors: Abdellah Mohammad H.M. , Tawfik Nabawia M. , Tony Effat Abd-Elhady , Mahmoud Amal A.A. , Ali Seham M. , Khairallah Marwa K. 
Published: January 2023

Background
Chronic hyperglycemia is a characteristic feature of diabetes mellitus and responsible for its long-term microvascular and macrovascular complications. One of the most problematic issues concerning diabetes complications is diabetic nephropathy ending with renal impairment and costly treatment. Defining new biomarkers to detect renal affection in diabetic patients is necessary. So, we aimed to evaluate serum immunoglobulin G (IgG) as a marker of early renal affection.

Patients and methods
In this study, 50 patients with type-2 diabetes were selected and classified according to their albuminuria and glomerular filtration rate, 25 apparently healthy participants were enrolled as a control group. We measured serum IgG levels in patients and control groups.

Results
Significant higher mean levels of serum IgG were observed with diabetic patients more than the control group and higher in patients with normoalbuminuria and microalbuminuria with P value less than 0.001 for each, however, significant lowest mean levels of serum IgG in the patients with macroalbuminuria when compared with other degrees of albuminuria, significantly higher mean levels of serum IgG were observed in stage-IV nephropathy when compared with other stages of chronic kidney disease (P≤0.001). There was a significant positive correlation between serum IgG and blood urea, serum creatinine, glycosylated hemoglobin, and albuminuria and proteinuria, and a significant negative correlation with estimated glomerular filtration rate with a significant difference in microvascular and macrovascular complications between the stages of chronic kidney disease and serum IgG levels.

Conclusion
Serum IgG is a simple test that can be used as a predictive biomarker for early renal affection in type-2 diabetic patients.
Brain fog and vessel clogs
Authors: Maitray Aditya , Kuriakose Anju , Rajendran Anand , Srinivasan Karthik , Mahalingam Maanasi 
Published: January 2023

Abstract
We present a unique case of a 36-year-old female presenting with features suggestive of bilateral combined vascular occlusion, hearing loss, and encephalopathy. Multimodal imaging was done for both eyes fundus evaluation including wide-field color fundus photography, optical coherence tomography, and fundus fluorescein angiography. After extensive ocular and systemic investigations, she was diagnosed to have Susac syndrome (SS). She was referred to a neurologist and otologist for systemic evaluation and underwent laser photocoagulation in both eyes, followed by pars plana vitrectomy in her left eye. Combined bilateral retinal vascular occlusion in association with SS is very rare.
Características clínicas y evolución de la infección por SARS-CoV-2 en pacientes con lupus eritematoso sistémico en Argentina: datos del registro nacional SAR-COVID
Authors: Isnardi Carolina Ayelén , Roberts Karen , Tissera Yohana , Petkovic Ingrid , Berbotto Guillermo , Gobbi Carla , Tanten Romina , Cogo Karina , Asnal Cecilia , Baños Andrea , Vivero Florencia , Schmid María Marcela , Lázaro María Alicia , German Noelia , Takashima Lorena , Scafati Julia , Werner Marina Laura , Casalla Luciana , Matellan Carla , Castrillon Diana M. , Rodríguez Florencia , Moyano Sebastián , Martín María Luz , Cosentino Vanesa , Herscovich Natalia , Tralice Elda R. , Barbich Tatiana , Vásquez Dora L. , Buschiazzo Emilio , Maid Pablo , Ledesma Ana C. , Yohena Víctor , Gómez Gimena , Quintana Rosana , Pons-Estel Guillermo J. 
Published: January 2023

Introducción: el lupus eritematoso sistémico (LES) es una enfermedad sistémica que se ha asociado a mayor severidad con la infección por SARS-CoV-2. Particularmente la alta actividad de la enfermedad y algunos inmunosupresores se han vinculado a peores desenlaces.
Objetivos: describir las características por SARS-CoV-2 en pacientes con LES en Argentina del registro SAR-COVID y establecer los factores asociados a peor desenlace de la misma.
Materiales y métodos: estudio observacional. Se incluyeron pacientes con diagnóstico de LES con infección confirmada por SARS-CoV-2 (RT-PCR y/o serología positiva) del registro SAR-COVID. Los datos se recolectaron desde agosto de 2020 hasta marzo de 2022. El desenlace de la infección se midió mediante la escala ordinal de la Organización Mundial de la Salud (EO-OMS). Se definió COVID-19 severo con un valor EO-OMS ≥5. Análisis descriptivo, test T de Student, U de Mann Whitney U, ANOVA, chi2 y Fisher. Regresión logística múltiple.
Resultados: se incluyeron 399 pacientes, el 93% de sexo femenino, con una edad media de 40,9 años (DE 12,2). El 39,6% tenía al menos una comorbilidad. Al momento de la infección, el 54,9% recibía glucocorticoides, el 30,8% inmunosupresores y el 3,3% agentes biológicos. La infección por SARS-CoV-2 fue leve en la mayoría de los casos, mientras que un 4,6% tuvo curso severo y/o falleció. Estos últimos presentaban comorbilidades, usaban glucocorticoides y tenían síndrome antifosfolípido (SAF) con mayor frecuencia y mayor actividad de la enfermedad al momento de la infección. En el análisis multivariado, la hipertensión arterial, el diagnóstico de SAF y el uso de glucocorticoides se asociaron a hospitalización severa y/o muerte por COVID-19 (EO-OMS ≥5).
Conclusiones: en esta cohorte de pacientes con LES con infección por SARS-CoV-2 confirmada, la mayoría cursó de manera sintomática, un 22,1% fue hospitalizado y un 5% requirió ventilación mecánica. La mortalidad fue cercana al 3%. El diagnóstico de SAF, tener hipertensión arterial y el uso de glucocorticoides se asociaron significativamente con COVID-19 severo.
Estudio de factibilidad para una microempresa de asesoría y venta de insumos para huertos familiares en Delicias, Chihuahua
Authors: Sánchez-Aguirre Javier Alejandro , Terrazas-Gómez Marina Imelda , Baray-Guerrero María Del Rosario , Villarreal-Ramírez Víctor Hugo , Aguirre-Avilés Edmundo José 
Published: January 2023

En el proyecto de estudio de factibilidad para una microempresa de asesoría y venta de insumos para huertos familiares en Cd. Delicias, Chihuahua se logró desarrollar un plan de factibilidad económica de la empresa, de publicidad y comercialización de huertos familiares. Como primer paso se realizó un estudio de mercado dirigido a la población de Cd. Delicias, Chihuahua en donde la muestra fue de 400 jefes de familia encuestados. Una vez obtenida esta información se realizaron gráficas y análisis de datos para determinar la aceptación del producto y servicio; se realizó un análisis de competencia con tres empresas de la ciudad dando como resultado una ventaja competitiva derivada de la calidad del producto y la completa variedad que se ofrece para que las familias puedan complementar su dieta alimenticia diaria, además de la adaptación de este a las necesidades del cliente sumado al precio accesible que la empresa ofrece con posible asesoría a mediano plazo para el cuidado oportuno de su producto. Se procedió a la creación de misión, visión, valores, metas organizacionales, distribución de la planta, así como una matriz FODA y el estudio de rentabilidad (TIR, VAN, beneficio-costo y punto de equilibrio) para la posible creación de la microempresa.
KEPEMIMPINAN SPIRITUAL KH. ABDUL GHOFIR NAWAWI DALAM MENUMBUHKAN KEHIDUPAN MODERASI BERAGAMA
Authors: Astutik Dian , Al-Habsyi Ni’ma M. , Polamolo Fika Magfirah 
Published: January 2023

This study aims to uncover the spiritual leadership of a Kyai in fostering religious moderation. The method used is descriptive qualitative with a phenomenological approach with primary and secondary data sources. Data collection techniques are observation, interviews, and documentation. Data analysis techniques consist of data collection, data reduction, data presentation, and drawing conclusions. The results showed that spiritual leadership, K.H. Abdul Ghofir Nawawi, among others, has been implemented at the Salafiyah Syafi'iyah Randangan Gorontalo Islamic Boarding School, namely: attitude honesty of heart in fostering religious moderation, Faimes attitude in fostering religious moderation, and humility in fostering religious moderation
Review on Social Media and Digital Security
Authors: Yahya Hussien Amar 
Published: January 2023

The emerging social media with inherent capabilities seems to be gaining edge over comprehensiveness, diversity and wisdom, nevertheless its security and trustworthiness issues have also become increasingly serious, which need to be addressed urgently. The available studies mainly aim at both social media content and user security, including model, protocol, mechanism and algorithm. Unfortunately, there is a lack of investigating on effective and efficient evaluations and measurements for security and trustworthiness of various social media tools, platforms and applications, thus has effect on their further improvement and evolution. To address the challenge, this paper firstly made a survey on the state-of-the-art of social media networks security and trustworthiness particularly for the increasingly growing sophistication and variety of attacks as well as related intelligence applications. And then, we highlighted a new direction on evaluating and measuring those fundamental and underlying platforms, meanwhile proposing a hierarchical architecture for crowd evaluations based on signaling theory and crowd computing, which is essential for social media ecosystem. Finally, we conclude our work with several open issues and cutting-edge challenges.