bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Phase I Study of Combination Olaparib and Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Bone Metastases (COMRADE)
Authors: Pan Elizabeth , Xie Wanling , Ajmera Archana , Araneta Arlene , Jamieson Christina , Folefac Edmund , Hussain Arif , Kyriakopoulos Christos E. , Olson Adam , Parikh Mamta , Parikh Rahul , Saraiya Biren , Ivy S. Percy , Van Allen Eliezer M. , Lindeman Neal I. , Kochupurakkal Bose S. , Shapiro Geoffrey I. , McKay Rana R. 
Published: February 2023

AbstractGiven that radium-223 is a radiopharmaceutical that induces DNA damage, and olaparib is a PARP inhibitor that interferes with DNA repair mechanisms, we hypothesized their synergy in metastatic castration-resistant prostate cancer (mCRPC). We sought to demonstrate the safety and efficacy of olaparib + radium-223.We conducted a multicenter phase I 3+3 dose escalation study of olaparib with fixed dose radium-223 in patients with mCRPC with bone metastases. The primary objective was to establish the RP2D of olaparib, with secondary objectives of safety, PSA response, alkaline phosphatase response, radiographic progression-free survival (rPFS), overall survival, and efficacy by homologous recombination repair (HRR) gene status.Twelve patients were enrolled; all patients received a prior androgen receptor signaling inhibitor (ARSI; 100%) and 3 patients (25%) prior docetaxel. Dose-limiting toxicities (DLT) included cytopenias, fatigue, and nausea. No DLTs were seen in the observation period however delayed toxicities guided the RP2D. The RP2D of olaparib was 200 mg orally twice daily with radium-223. The most common treatment-related adverse events were fatigue (92%) and anemia (58%). The rPFS at 6 months was 58% (95% confidence interval, 27%–80%). Nine patients were evaluable for HRR gene status; 1 had a BRCA2 alteration (rPFS 11.8 months) and 1 had a CDK12 alteration (rPFS 3.1 months).Olaparib can be safely combined with radium-223 at the RP2D 200 mg orally twice daily with fixed dose radium-223. Early clinical benefit was observed and will be investigated in a phase II study.
Sex Differences in 10-Year Outcomes After Percutaneous Coronary Intervention With Drug-Eluting Stents: Insights From the DECADE Cooperation
Authors: Coughlan J.J. , Räber Lorenz , Brugaletta Salvatore , Kufner Sebastian , Maeng Michael , Jensen Lisette Okkels , Ortega-Paz Luis , Bär Sarah , Laugwitz Karl-Ludwig , Madsen Morten , Heg Dik , Aytekin Alp , Windecker Stephan , Olesen Kevin Kris Warnakula , Sabaté Manel , Kastrati Adnan , Cassese Salvatore 
Published: February 2023

Background:
Although some studies have investigated sex-related outcomes up to 5 years after percutaneous coronary intervention (PCI), analyses at longer follow-up (ie, to 10 years) in large cohorts treated exclusively with drug-eluting stent (DES) platforms are lacking. Therefore, this study aimed to define whether sex-related differences in long-term outcomes after PCI persist both in the DES era and at longer-term follow-up.

Methods:
Individual data of patients treated with DES in 5 randomized controlled trials with 10-year follow-up were pooled. Patients were divided into 2 groups by sex. The analysis of individual participant data was performed using a 1-stage approach by entering a clustering effect by parent study in all univariable and multivariable models focusing on sex. The main outcomes of interest for this analysis included cardiovascular death, myocardial infarction, repeat revascularization, and definite stent thrombosis to 10 years after PCI. Survival was analyzed by the Kaplan-Meier method to estimate the time to first event, and differences between the 2 groups were tested with the log-rank test. Hazard ratios (HRs) and 95% CIs were calculated with a Cox proportional hazards model. Conventional multivariable analyses with adjustment for relevant variables were performed.

Results:

Among 9700 patients undergoing PCI with DES implantation included in the present analysis, 2296 were women and 7404 were men. Through to 10 years, cardiovascular death occurred in 407 of the 2296 female patients and 1012 of the 7404 male patients (adjusted HR [HR
adj
], 0.94 [95% CI, 0.80–1.11]). Female sex was associated with a lower risk of repeat revascularization of the target lesion (HR
adj
, 0.80 [95% CI, 0.74–0.87]), target vessel (HR
adj
, 0.81 [95% CI, 0.76–0.87]), and nontarget vessels (HR
adj
, 0.69 [95% CI, 0.62–0.77]). Compared with male patients, female patients displayed an increased risk of myocardial infarction in the first 30 days after PCI with DES (HR
adj
, 1.65 [95% CI, 1.24–2.19]) but a comparable risk of myocardial infarction thereafter. The risk of definite stent thrombosis was not significantly different between female and male patients (HR
adj
, 1.14 [95% CI, 0.89–1.47]).

Conclusions:
Through to 10-year follow-up after PCI with DES, female patients are at increased risk of early myocardial infarction, receive fewer repeat revascularizations, and have no difference in cardiovascular mortality compared with male patients.
Relationships of Hemoglobin Concentration, Ischemic Lesions, and Clinical Outcomes in Patients With Intracerebral Hemorrhage
Authors: Roh David J. , Boehme Amelia , Mamoon Rayan , Hooper Destiny , Cottarelli Azzurra , Ji Robin , Mao Eric , Kumar Aditya , Carvalho Poyraz Fernanda , Demel Stacie L. , Spektor Vadim , Carmona Jerina , Hod Eldad A. , Ironside Natasha , Gutierrez Jose , Guo Jia , Konofagou Elisa , Elkind Mitchell S.V. , Woo Daniel 
Published: February 2023

Background:
Hemoglobin concentration and diffusion-weighted imaging (DWI) ischemic lesions are separately known to be associated with poor intracerebral hemorrhage (ICH) outcomes. While hemoglobin concentrations have known relationships with ischemic stroke, it is unclear whether hemoglobin concentration is associated with DWI ischemic lesions after ICH. We sought to investigate the hypothesis that hemoglobin concentrations would associate with DWI lesions after ICH and further investigated their relationships with clinical outcomes.

Methods:
Supratentorial ICH patients enrolled between 2010 and 2016 to a prospective, multicenter, observational cohort study (ERICH study [Ethnic/Racial Variations of Intracerebral Hemorrhage]) were assessed. Patients from this study with baseline, admission hemoglobin, and hospitalization magnetic resonance imaging were analyzed. Hemoglobin was examined as the primary exposure variable defined as a continuous variable (g/dL). Magnetic resonance imaging DWI ischemic lesion presence was assessed as the primary radiographic outcome. Primary analyses assessed relationships of hemoglobin with DWI lesions. Secondary analyses assessed relationships of DWI lesions with poor 3-month outcomes (modified Rankin Scale score, 4–6). These analyses were performed using separate multivariable logistic regression models adjusting for relevant covariates.

Results:
Of 917 patients with ICH analyzed, mean baseline hemoglobin was 13.8 g/dL (±1.9), 60% were deep ICH, and DWI lesions were identified in 27% of the cohort. In our primary analyses, increased hemoglobin, defined as a continuous variable, was associated with DWI lesions (adjusted odds ratio, 1.21 per 1 g/dL change in hemoglobin [95% CI, 1.07–1.37]) after adjusting for sex, race, ICH severity, time to magnetic resonance imaging, and acute blood pressure change. In secondary analyses, DWI lesions were associated with poor 3-month outcomes (adjusted odds ratio, 1.83 [95% CI, 1.24–2.69]) after adjusting for similar covariates.

Conclusions:
We identified novel relationships between higher baseline hemoglobin concentrations and DWI ischemic lesions in patients with ICH. Further studies are required to clarify the role of hemoglobin concentration on both cerebral small vessel disease pathophysiology and ICH outcomes.
HUSS: A Heuristic Method for Understanding the Semantic Structure of Spreadsheets
Authors: Wu Xindong , Chen Hao , Bu Chenyang , Ji Shengwei , Zhang Zan , Sheng Victor S. 
Published: February 2023

ABSTRACT
Spreadsheets contain a lot of valuable data and have many practical applications. The key technology of these practical applications is how to make machines understand the semantic structure of spreadsheets, e.g., identifying cell function types and discovering relationships between cell pairs. Most existing methods for understanding the semantic structure of spreadsheets do not make use of the semantic information of cells. A few studies do, but they ignore the layout structure information of spreadsheets, which affects the performance of cell function classification and the discovery of different relationship types of cell pairs. In this paper, we propose a Heuristic algorithm for Understanding the Semantic Structure of spreadsheets (HUSS). Specifically, for improving the cell function classification, we propose an error correction mechanism (ECM) based on an existing cell function classification model [11] and the layout features of spreadsheets. For improving the table structure analysis, we propose five types of heuristic rules to extract four different types of cell pairs, based on the cell style and spatial location information. Our experimental results on five real-world datasets demonstrate that HUSS can effectively understand the semantic structure of spreadsheets and outperforms corresponding baselines.
Improving Short-Term QPF Using Geostationary Satellite All-Sky Infrared Radiances: Real-Time Ensemble Data Assimilation and Forecast during the PRECIP 2020 and 2021 Experiments
Authors: Zhang Yunji , Chen Xingchao , Bell Michael M. 
Published: February 2023

Abstract
The Prediction of Rainfall Extremes Campaign In the Pacific (PRECIP) aims to improve our understanding of extreme rainfall processes in the East Asian summer monsoon. A convection-permitting ensemble-based data assimilation and forecast system (the PSU WRF-EnKF system) was run in real time in the summers of 2020–21 in advance of the 2022 field campaign, assimilating all-sky infrared (IR) radiances from the geostationary Himawari-8 and GOES-16 satellites, and providing 48-h ensemble forecasts every day for weather briefings and discussions. This is the first time that all-sky IR data assimilation has been performed in a real-time forecast system at a convection-permitting resolution for several seasons. Compared with retrospective forecasts that exclude all-sky IR radiances, rainfall predictions are statistically significantly improved out to at least 4–6 h for the real-time forecasts, which is comparable to the time scale of improvements gained from assimilating observations from the dense ground-based Doppler weather radars. The assimilation of all-sky IR radiances also reduced the forecast errors of large-scale environments and helped to maintain a more reasonable ensemble spread compared with the counterpart experiments that did not assimilate all-sky IR radiances. The results indicate strong potential for improving routine short-term quantitative precipitation forecasts using these high-spatiotemporal-resolution satellite observations in the future.

Significance Statement
During the summers of 2020/21, the PSU WRF-EnKF data assimilation and forecast system was run in real time in advance of the 2022 Prediction of Rainfall Extremes Campaign In the Pacific (PRECIP), assimilating all-sky (clear-sky and cloudy) infrared radiances from geostationary satellites into a numerical weather prediction model and providing ensemble forecasts. This study presents the first-of-its-kind systematic evaluation of the impacts of assimilating all-sky infrared radiances on short-term qualitative precipitation forecasts using multiyear, multiregion, real-time ensemble forecasts. Results suggest that rainfall forecasts are improved out to at least 4–6 h with the assimilation of all-sky infrared radiances, comparable to the influence of assimilating radar observations, with benefits in forecasting large-scale environments and representing atmospheric uncertainties as well.
Molecular characterization of physis tissue and hormonal profiles of female rats neonatally exposed to low-dose bisphenol A
Authors: Jiang Chenyan , Gao Guanglin , Sun Wen , Sun Yanyan , Yu Jian 
Published: February 2023

Physis is a complex cartilaginous structure that is critical for longitudinal bone growth. As one of the endocrine-disrupting chemicals, bisphenol A (BPA) can interfere with the physis by deranging the complex networks of nutritional, cellular, paracrine, and endocrine factors, and this affects longitudinal bone growth, leading to different growth outcomes. However, the exact mechanisms underlying these phenomena remain unclear. Therefore, understanding the molecular pathways involved in the physis after neonatal exposure to low-dose BPA may permit the identification of research targets for therapeutics, which may aid in modulating the process of growth plate closure. In the present study, female Sprague–Dawley rats were exposed to 0.05 mg·kg−1·day−1 of BPA and corn oil vehicle from postnatal day 1 (PND1) to 15 via subcutaneous injection. Next-generation RNA sequencing was performed for the mRNA isolated from the physis. The levels of osteocalcin (OC), growth hormone (GH), and insulin-like growth factor 1 (IGF-1) were measured on PND30 (BPA0.05mg vs. Vehicle; n = 5 for each group). We observed statistically significant enrichment of gene sets in the BPA0.05mg tissues compared with the Vehicle tissues. Further analysis of the differentially expressed genes (DEGs) identified BPA0.05mg-specific networks of secreted proteins (LEP, NPY, AGT, ACE2, C4B, and C4BPA) as well as those of local matrix and protease proteins (FBN2, LAMC2, ADAMTS16, and ADAMTS19). Furthermore, the levels of OC and GH were affected by BPA exposure. Our results revealed the specific molecular characteristics of physis contaminated with BPA and may provide new clues for physis maturation and supervision of industrial products and occupational exposure.
Albiflorin ameliorates mesangial proliferative glomerulonephritis by PI3K/AKT/NF-κB pathway
Authors: Yu Haiyan , Wang Yu , He Zida , Chen Ruixue , Dai Yingni , Tang Yingqian , Chen Ye 
Published: February 2023

Background: The most common type of glomerulonephritis in China is mesangial proliferative glomerulonephritis (MPGN) featured with mesangial cell overproliferation and inflammation, as well as fibrosis. Albiflorin (AF) is an effective composition extracted from Paeonia Alba Radix and has been administrated for various diseases. Nevertheless, there is no research reporting the effect of AF on MPGN. Purpose: Our work aims to probe into the role and possible mechanism of AF on MPGN. Research Design: We investigated the effects of AF on mesangial cell overproliferation, inflammation, and fibrosis in vitro and in vivo and identified the related signaling pathways. Study Sample: human mesangial cells (HMCs) and male Sprague Dawley (SD) rats. Data Analysis: SPSS 18.0 was used to analyze the data. Results: AF attenuated the proliferation and inflammation both in vitro and in vivo. In detail, AF decreased the ki67 expression in lipopolysaccharides (LPS)-treated HMCs and MPGN rats, and the mRNA expression or contents of inflammatory cytokines were reduced after AF treatment. The fibrosis of LPS-treated HMCs and MPGN rats was also reduced by AF. Moreover, AF effectively restrained 24 h urinary protein, improved kidney function, and mitigated dyslipidemia and pathological injury of MPGN rats. Additionally, we found that the protective effects of AF were accompanied by the blocking of PI3K/AKT/NF-κB pathway, and the inhibitory effects of AF on MPGN were reversed by insulin-like growth factor (IGF-1), the PI3K agonist. Conclusions: AF alleviates MPGN via restraining mesangial cell overproliferation, inflammation, and fibrosis via PI3K/AKT/NF-κB signaling.
A tale of two continents: The performance of six early warning scores in two emergency departments
Authors: Lo Ronson Sze Long , Lyngholm Le Elias , Brabrand Mikkel , Leung Ling Yan , Hung Kevin Kei Ching , Laugesen Sune , Posth Stefan , Cooksley Tim , Graham Colin A , Nickel Christian H 
Published: February 2023

Background: Several early warning scores have been designed to optimize acute care by identifying patients at risk of deterioration. Methods: In this post hoc dual center study, we analyzed the performance of six clinical scores (the Goodacre score, Groarke, Worthing Physiological Score, Rapid Acute Physiology Score, Rapid Emergency Medicine Score, United Kingdom National Early Warning Score. The primary outcome is 30-day all-cause mortality after inclusion and data were obtained from previous studies performed at two different emergency departments on two continents (Denmark, Europe, and Hong Kong, Asia). Results: We included 2952 people; 1482 (50.2%) were male, mean age (standard deviation) was 65.7 (18.3) years, and 109 (3.7%) died within 30 days. Mortality rate increased steadily with increasing scores for all six scoring systems in Hong Kong while this was less obvious in Denmark. In all patients, Rapid Acute Physiology Score had the lowest discriminatory power while National Early Warning Score had the highest. National Early Warning Score performed best in Hong Kong while Worthing performed marginally better in Denmark. Discussion: Surprisingly, the performance of the scoring systems varied considerably, but were largely unaffected by location, and none of them performed close to what clinicians would normally require for predicting 30-day all-cause mortality Conclusion: All scores performed similarly across both centers, with poor prediction of 30-day all-cause mortality. Based on these findings, we believe that clinical scores must be supplemented by either biochemical values or global markers of physiological reserve to reflect reality and to be of true value.
Everyday Cognitive Control and Emotion Dysregulation in Young Adults With and Without ADHD: An Ecological Momentary Assessment Study
Authors: Ben-Dor Cohen Maayan , Maeir Adina , Eldar Eran , Nahum Mor 
Published: February 2023

Objective: This study examined the contribution of the temporal dynamics of two cognitive control mechanisms—inhibitory control (IC) and working memory (WM)—to emotion dysregulation (ED) in attention-deficit/hyperactivity disorder (ADHD) in ecological settings. Method: One hundred twenty-two participants (age 18–33 years; 60 with ADHD) reported their ED at baseline, followed by a 5-day ecological momentary assessment (EMA) study, with short behavioral IC and WM tasks performed five times/day. Results: For IC, mean and lability of performance over EMA significantly accounted for differences in ED but not baseline performance. For WM, both baseline and mean of EMA, but not EMA lability, accounted for ED variance. ADHD status further contributed to the explained variance of ED. Conclusions: Our results support the contribution of dynamic IC processes to ED in ADHD, in addition to WM performance level, and highlight the importance of dynamic and ecological investigation of different cognitive control components.
Predictors of Quality of Life and Functional Impairments in Emerging Adults With and Without ADHD: A 10-Year Longitudinal Study
Authors: Orm Stian , Øie Merete Glenne , Fossum Ingrid Nesdal , Fjermestad Krister , Andersen Per Normann , Skogli Erik Winther 
Published: February 2023

Objective: We tested the hypotheses that (1) a diagnosis of ADHD in childhood or adolescence is associated with reduced quality of life (QoL) and everyday functioning in emerging adulthood, and (2) executive function (EF) deficits, internalizing difficulties, and ADHD symptoms predict reduced QoL and more functional impairments. Method: We assessed 85 children and adolescents with ADHD and 50 typically developing (TD) peers at baseline ( Mage = 11.6 years, 58% males), 2-year follow-up, and 10-year follow-up with neuropsychological tests of EF and self-reports. Results: Individuals with ADHD reported lower QoL and functional impairments in emerging adulthood compared to TD peers. More internalizing difficulties and ADHD symptoms at baseline and 2-year follow-up significantly predicted lower QoL and more functional impairments at the 10-year follow-up. Conclusion ADHD and internalizing difficulties in childhood or adolescence have a negative impact on QoL and everyday functioning in emerging adulthood.
A new approach to digital health? Virtual COVID-19 care: A scoping review
Authors: Chung-Lee Leinic , Catallo Cristina 
Published: February 2023

Aims The use of virtual care enabled by digital technologies has increased, prompted by public health restrictions in response to COVID-19. Non-hospitalized persons in the acute phase of COVID-19 illness may have unique health needs while self-isolating in the community. This scoping review aimed to explore the nature of care, the use of digital technologies, and patient outcomes arising from virtual care among community-based self-isolating COVID-19 patients. Methods Literature searches for peer-reviewed articles were conducted in four bibliographic databases: CINAHL, Medline, Embase and Cochrane Database of Systematic Reviews between January and February 2022, followed by hand-searching reference lists of included articles. Two levels of screening using defined eligibility criteria among two independent reviewers were completed. Results Of the 773 articles retrieved, 19 were included. Results indicate that virtual care can be safe while enabling timely detection of clinical deterioration to improve the illness trajectory. COVID-19 virtual care was delivered by single health professionals or by multidisciplinary teams using a range of low-technology methods such as telephone to higher technology methods like wearable technology that transmitted physiological data to the care teams for real-time or asynchronous monitoring. Conclusion The review described the varied nature of virtual care including its design, implementation, and evaluation. Further research is needed for continued exploration on how to leverage digital health assets for the delivery of appropriate and safe virtual COVID-19 community care, which can support patient recovery, control transmission, and prevent intensifying the burden on the health care system, especially during surges.
A supplementary study on the Chinese writings in Pidgin English Lyrics
Authors: Nie Daxin 
Published: February 2023

Chinese Pidgin Language has existed in the southern coastal areas of China since the 16th century and is a lingua franca of European languages, Mandarin and Chinese dialects, influenced by the class of users and the particular using occasion. Chinese people mainly rely on Chinese transcriptions to express and record this idiosyncratic dialect without regard for original foreign letters and spelling rules. This method, however, reserves the dialectal phonetic feature and writing system of sight words in an early period. Limited by the material recorded, relevant concerns about Chinese Pidgin Language have been at a standstill. Referring to the regional variations, studies on Yang King Pang English needs to be worthy of attention. By referring to the corresponding agreements of Chinese Pidgin Language extracted from earlier studies as well as the historical evidence, the present article makes a thorough correction of and supplement to all questioned Chinese transcriptions embedded in these Pidgin English Lyrics not well-known by the academic. The achievement, integrated with the existing transcriptions of these lyrics, would provide one complete glossary of Yang King Pang English in that period.