bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of recovery profile dependency in time‐dependent resilience
Authors: Wang Cao 
Published: June 2023

AbstractResilience assessment of civil structures and infrastructure systems plays a vital role in quantitatively measuring the object's ability to withstand and recover from disruptive events (e.g., natural hazards). The performance of the object (structure or system) may degrade with time, and the external loads often display nonstationary characteristics with time‐varying occurrence rate and/or magnitude. In this context, the resilience would be dependent on the duration of the reference period of interest, known as time‐dependent resilience. This article investigates the effect of recovery profile dependency on the time‐dependent resilience of structures and systems. The term “recovery profile dependency” refers to the association of the post‐hazard recovery processes in the aftermath of different load events within the object's service life, and is reflected through the following three aspects: (1) the temporal correlation between the remaining functionalities associated with different load events; (2) the load–recovery interaction (i.e., the scenario that a load event occurs before the full recovery of the degraded functionality due to the previous load event), and (3) the resource allocation strategy in the presence of limited resources, which affects the expeditiousness of each recovery process. In particular, for (2), the concept of average ratio of interaction is proposed to measure the frequency of load‐recovery interaction. The evaluation of time‐dependent resilience is demonstrated through two examples. It is shown that, the time‐dependent resilience is sensitive to the impact of load–recovery interaction and the selection of resource allocation strategy, but is insensitive to the temporal correlation of the remaining functionalities.
Potential benefits of Rehmanniae Radix after ancient rice‐steaming process in promotion of antioxidant activity in rats' health
Authors: Zhang Ying , Wu Meng‐xi , Li Hong‐mei , Sun Jianhui , Huang Lu‐qi , Yuan Yuan 
Published: June 2023

AbstractRice steam processed product of Rehmanniae Radix (RSRR), one of the processed products of Rehmanniae Radix (RR), is popular as an herbal medicine and food. However, the health‐promoting effects and mechanisms of RSRR are still unclear. In this study, 10‐week‐old Sprague–Dawley female rats were treated with different processed products of RR. No organ coefficient differences were observed between RSRR and the control group, indicating that RSRR did not cause damage to the rats. Compared with other RR products, superoxide dismutase, glutathione, and catalase levels were significantly higher and malondialdehyde levels were significantly lower in the RSRR group, indicating that RSRR exerted a better antioxidant effect. Gene expression analysis showed that hemoglobin genes (Hba‐a1, Hba‐a2, Hbb‐bs, Hbb, Hbq1b, Hbb‐b1, and LOC103694857) may be potential biomarkers to evaluate the antioxidant effect of RSRR. Antioxidation‐related signaling pathways in GO annotation, including cellular oxidant detoxification, hydrogen peroxide metabolic process, hemoglobin complex, and oxygen binding signaling pathways were significantly enriched, indicating these pathways may represent the antioxidant mechanism of RSRR. To explore the main active compounds primarily responsible for the antioxidant activity of RSRR, UPLC‐Q‐TOF‐MS was used and six components (catalpol, rehmannioside A, rehmannioside D, melittoside, ajugol, and verbascoside) were identified in rat serum. Catalpol and rehmannioside A were predicted to be the major active components by network pharmacology. These results suggested that RSRR exhibits antioxidant activity and has health‐promoting properties. This study provides a scientific basis for the antioxidant mechanism and clinical use of RSRR.
A nurse‐led positive psychological intervention among elderly community‐dwelling adults with mild cognitive impairment and depression: A non‐randomized controlled trial
Authors: Yao Xiuyu , Wang Yidan , Zhou Ying , Li Zheng 
Published: June 2023

AbstractBackgroundOlder adults with mild cognitive impairment (MCI) and depression have a higher dementia conversion rate, which requires timely intervention.ObjectivesA non‐randomized controlled trial was conducted to explore the effect of a nurse‐led positive psychological intervention (PPI) in relieving depression and promoting cognition in this population.MethodsA total of 70 older adults were enrolled, with 35 each in the intervention and control groups. The control group received one‐to‐one health education, and the intervention group received a 40‐ to 60‐minute PPI for eight successive weeks.ResultsDuring the intervention, most participants reached the standard of active participation, and 2.86% continued to complete homework every day during follow‐up. The Patient Health Questionnaire‐9 (PHQ‐9) score in the intervention group was significantly lower than that in the control group at the end of intervention (t = −3.64, p < 0.05) and at 3‐month follow‐up (t = −4.48, p < 0.05). Interaction effects of time and group on PHQ‐9 scores (F = 8.11, p < 0.001), with significant differences between the groups in scores (F = 9.11, p < 0.05) and times (F = 23.58, p < 0.05) was observed. In the Montreal Cognitive Assessment (MoCA) scale, the intervention group had significantly higher scores than controls at the end of intervention (t = 7.28, p < 0.05) and 3‐month follow‐up (t = 8.01, p < 0.05). Cognition in the two groups was significantly affected by intergroup effects (F = 42.80, p < 0.001), interaction effects (F = 30.38, p < 0.001), and time effects (F = 33.67, p < 0.05).ConclusionsAlthough the effects tended to decrease in follow‐up, the nurse‐led PPI was feasible and valid in relieving depression and promoting cognition among older participants with MCI and depression. The present findings warrant further exploration.Tweetable abstractA nurse‐led positive psychological intervention was applicable among elderly MCI adults with depression and effective in relieving depression and promoting cognition.
Striatonigrostriatal connectivity‐based cross‐species parcellation of human and macaque substantia nigra
Authors: Xia Xiaoluan , Zeng Xinglin , Gao Fei , Hua Lin , Huang Shaohui , Yuan Zhen 
Published: June 2023

AbstractAnatomical and functional heterogeneous substantia nigra (SN) has been extensively studied in humans and animals like rhesus monkeys given its crucial role in modulating a broad range of behaviors. Increasingly important cross‐species research of SN may require connectionally homogeneous and homologous subregions of SN as objective and stable starting points from which the evolutionary characteristics of brain could be inspected. However, existing atlases of SN were all inaccurate mappings as a cross‐species connectome atlas due to inadequate homology constraint during their constructions, and arbitrary paired use of these atlases might cause unreliable findings. In this study, a reliable blind‐source cross‐species parcellation of SN was developed based on the following rationale: striatonigrostriatal circuits form major structure of nigral connectivity; different nigral components have unique striatonigrostriatal connectivity; and inter‐species corresponding human and macaque nigral components have similar striatonigrostriatal connectivity. Specifically, all voxels in human and macaque SN were grouped together and then classified based on inter‐species identically characterized striatonigrostriatal connectivity attributes. Our results delineated a pars compacta‐pars reticulate‐like parcellation and further demonstrated its reliability by illustrating best‐matched whole‐brain structural and functional connectivity profiles of inter‐species corresponding nigral subregions. Detailed inter‐species and inter‐regional differences in multi‐aspect connectivities of these nigral subregions were inspected. It is expected that this cross‐species connectome atlas of SN can offer biologically reliable cornerstones and important information to facilitate future cross‐species research.
Mnemonic discrimination deficits in multidimensional schizotypy
Authors: Sahakyan Lili , Wahlheim Christopher N. , Kwapil Thomas R. 
Published: June 2023

AbstractCurrent developmental psychopathology models indicate that schizophrenia can be understood as the most extreme expression of a multidimensional continuum of symptoms and impairment referred to as schizotypy. In nondisordered adults, schizotypy predicts risk for developing schizophrenia‐spectrum psychopathology. Schizophrenia is associated with disruptions in detecting subtle differences between objects, which is linked to hippocampal dysfunction. These disruptions have been shown in the Mnemonic Similarity Task (MST) when patients are less likely to reject lures that are similar but not identical to studied objects, and instead mistake them for studied items. This pattern of errors may be a behavioral manifestation of impaired pattern separation, a key episodic memory ability associated with hippocampal integrity and overreliance on pattern completion. We examined whether multidimensional schizotypy is associated with such deficits in nondisordered young adults. Participants (n = 230) were assessed for positive, negative, and disorganized schizotypy and completed the MST and a perceptual discrimination task. MST performance showed that a combination of elevated negative and disorganized schizotypy was associated with decreased rejections of similar lures because they were mistakenly identified as studied items. These deficits were not observed in traditional recognition measures within the same task, nor in perceptual discrimination, suggesting that mnemonic discrimination deficits assessed by MST were selective and did not reflect generalized deficits. These findings extend the results obtained in schizophrenia patients and support a multidimensional model of schizophrenia‐spectrum psychopathology.
Evaluating the effects of stream power on rill flow resistance
Authors: Nicosia Alessio , Pampalone Vincenzo , Serio Maria Angela , Ferro Vito 
Published: June 2023

AbstractLimited information is currently available on how sediment transport affects rill flow resistance and the influence of hydraulic variables, as stream power, on sediment transport capacity for rill flows. In this paper, the available measurements of hydraulic variables (flow depth, channel slope, mean flow velocity, Reynolds number, Froude number, and Darcy–Weisbach friction factor) carried out by Ban et al. (Measurement of rill and ephemeral gully flow velocities and their model expression affected by flow rate and slope gradient. Journal of Hydrology, 589, 125172) and Ban (Measurements and estimation of flow velocity in mobile bed rills. International Journal of Sediment Research, 38(1), 97–104) for fixed and mobile bed rills are used to test the applicability of a theoretically deduced rill flow resistance equation based on a power‐velocity profile. The results allowed for stating that (i) the theoretical flow resistance approach can predict Darcy–Weisbach friction factor for flows over fixed and mobile beds, (ii) the stream power, dependent on flow discharge and slope, determines different flow behaviour, and (iii) the data are supportive of the slope independence hypothesis of rill velocity, for the mobile bed condition, only for the highest investigated discharge values (greater than 0.133 L s−1).
Endometriosis and physical activity: A narrative review
Authors: Tourny Claire , Zouita Amira , El Kababi Samira , Feuillet Léa , Saeidi Ayoub , Laher Ismail , Weiss Katja , Knechtle Beat , Zouhal Hassane 
Published: June 2023

AbstractEndometriosis is a painful gynecological disorder that affects many women. Constant treatments and contraception changes affect women looking for solutions to treat and limit the problems caused by endometriosis. The current narrative review discusses the effects of physical activity on the management, pain, and quality of life in patients with endometriosis. Findings suggest that body awareness practices such as Hatha yoga, the Jacobson method, and progressive muscle relaxation reduce pain and stress and improve the quality of life associated with endometriosis. It also highlights the current knowledge gap on available evidence and future research. Moreover, care must be taken when considering patients' physical abilities and goals and avoiding intense physical activities. The forms of endometriosis and its symptoms vary from one woman to another, so it is important to perform studies with various nonmedicinal or surgical techniques. It is important to continue randomized controlled trials to obtain more data on the benefits of physical activity in women with endometriosis and also to identify what types of activities could be beneficial to combat pain symptoms and improve the daily lives of women with endometriosis.
Reversal of P‐glycoprotein‐mediated multidrug resistance by natural N‐alkylated indole alkaloid derivatives in KB‐ChR‐8‐5 drug‐resistant cancer cells
Authors: Bharathiraja Pradhapsingh , Cardoso David S. P. , Rajendra Prasad N. , Mulhovo Silva , Lakra Deepa S. , Ferreira Maria‐José U. 
Published: June 2023

AbstractMultidrug resistance (MDR) remains a significant challenge in cancer chemotherapy due to the overexpression of ATP‐binding cassette drug‐efflux transporters, namely P‐glycoprotein (P‐gp)/ATP‐binding cassette subfamily B member 1. In this study, derivatives of N‐alkylated monoterpene indole alkaloids such as N‐(para‐bromobenzyl) (NBBT), N‐(para‐methylbenzyl) (NMBT), and N‐(para‐methoxyphenethyl) (NMPT) moieties were investigated for the reversal of P‐gp‐mediated MDR in drug‐resistant KB colchicine‐resistant 8‐5 (KB‐ChR‐8‐5) cells. Among the three indole alkaloid derivatives, the NBBT exhibited the highest P‐gp inhibitory activity in a dose‐dependent manner. Further, it significantly decreased P‐gp overexpression by inactivating the nuclear translocation of the nuclear factor kappa B p‐50 subunit. In the cell survival assay, doxorubicin showed 6.3‐fold resistance (FR) in KB‐ChR‐8‐5 cells compared with its parental KB‐3‐1 cells. However, NBBT significantly reduced doxorubicin FR to 1.7, 1.3, and 0.4 and showed strong synergism with doxorubicin for all the concentrations studied in the drug‐resistant cells. Furthermore, NBBT and doxorubicin combination decreased the cellular migration and showed increased apoptotic incidence by downregulating Bcl‐2, then activating BAX, caspase 3, and p53. The present findings suggest that NBBT could be a lead candidate for the reversal of P‐gp‐ mediated multidrug resistance in cancer cells.
Establishing a mentorship program for prospective genetic counseling graduate students: Two cycles of program experience
Authors: Watson Elise , Moriarty Kelsey , Burns Madison , Diamonstein Callie 
Published: June 2023

AbstractMentorship has been a long‐standing and important piece of healthcare training, but few formal, structured mentorship programs exist in the genetic counseling field. Our report describes the creation and evaluation of the Genetic Counseling Assistant Mentorship Program (GCAMP) after two cycles of the program. Genetic counseling assistant (GCA) mentees were paired with genetic counselor mentors for support and advice primarily surrounding graduate school applications and professional development. Pairs were encouraged to meet at regular intervals, but the specific meeting patterns were determined by the pair based on the needs of the mentee. The GCAMP also involved electronic and interactive resources for mentees, which were continually developed. Many of the electronic resources were created and maintained by past and current GCAs, such as a list of local shadowing and advocacy opportunities and a list of factors to consider when evaluating graduate programs. Interactive resources included workshops, mock graduate school interviews, reviews of graduate school application materials, and social events. Mentors were also provided with resources about mentorship. Surveys were conducted to evaluate the program. Overall satisfaction with the program and the mentoring relationship was high among both mentees and mentors. In aggregate, results revealed that mentees felt strongly supported by the mentorship program and were highly satisfied with their mentorship experience. Results also showed that mentors enjoyed a high level of fulfillment and professional development themselves by participating in the program.
Exercise testing and prescription in patients with inborn errors of muscle energy metabolism
Authors: Batten Kiera , Bhattacharya Kaustuv , Simar David , Broderick Carolyn 
Published: June 2023

AbstractSkeletal muscle is a dynamic organ requiring tight regulation of energy metabolism in order to provide bursts of energy for effective function. Several inborn errors of muscle energy metabolism (IEMEM) affect skeletal muscle function and therefore the ability to initiate and sustain physical activity. Exercise testing can be valuable in supporting diagnosis, however its use remains limited due to the inconsistency in data to inform its application in IEMEM populations. While exercise testing is often used in adults with IEMEM, its use in children is far more limited. Once a physiological limitation has been identified and the aetiology defined, habitual exercise can assist with improving functional capacity, with reports supporting favourable adaptations in adult patients with IEMEM. Despite the potential benefits of structured exercise programs, data in paediatric populations remain limited. This review will focus on the utilisation and limitations of exercise testing and prescription for both adults and children, in the management of McArdle Disease, long chain fatty acid oxidation disorders, and primary mitochondrial myopathies.
Reproducibility in modeling and simulation of the knee: Academic, industry, and regulatory perspectives
Authors: Imhauser Carl W. , Baumann Andrew P. , Liu Xiangyi (Cheryl) , Bischoff Jeffrey E. , Verdonschot Nico , Fregly Benjamin J. , Elmasry Shady S. , Abdollahi Neda N. , Hume Donald R. , Rooks Nynke B. , Schneider Marco T.‐Y. , Zaylor William , Besier Thor F. , Halloran Jason P. , Shelburne Kevin B. , Erdemir Ahmet 
Published: June 2023

AbstractStakeholders in the modeling and simulation (M&S) community organized a workshop at the 2019 Annual Meeting of the Orthopaedic Research Society (ORS) entitled “Reproducibility in Modeling and Simulation of the Knee: Academic, Industry, and Regulatory Perspectives.” The goal was to discuss efforts among these stakeholders to address irreproducibility in M&S focusing on the knee joint. An academic representative from a leading orthopedic hospital in the United States described a multi‐institutional, open effort funded by the National Institutes of Health to assess model reproducibility in computational knee biomechanics. A regulatory representative from the United States Food and Drug Administration indicated the necessity of standards for reproducibility to increase utility of M&S in the regulatory setting. An industry representative from a major orthopedic implant company emphasized improving reproducibility by addressing indeterminacy in personalized modeling through sensitivity analyses, thereby enhancing preclinical evaluation of joint replacement technology. Thought leaders in the M&S community stressed the importance of data sharing to minimize duplication of efforts. A survey comprised 103 attendees revealed strong support for the workshop and for increasing emphasis on computational modeling at future ORS meetings. Nearly all survey respondents (97%) considered reproducibility to be an important issue. Almost half of respondents (45%) tried and failed to reproduce the work of others. Two‐thirds of respondents (67%) declared that individual laboratories are most responsible for ensuring reproducible research whereas 44% thought that journals are most responsible. Thought leaders and survey respondents emphasized that computational models must be reproducible and credible to advance knee M&S.
Biomarkers for disease progression identified in psoriasis patients: A pilot study
Authors: Mkhize Nomzamo , Kgokolo Mahlatse , Steel Helen , Meyer Pieter WA , Kwofie Luyanda 
Published: June 2023

AbstractBackgroundPsoriasis is an immune‐mediated polygenic skin disorder. It is influenced by multiple genes as well as environmental factors including infection and trauma. Psoriasis is associated with molecular biomarkers such as HLA‐C*06:02 and associated single‐nucleotide variants (SNVs). Furthermore, the circulatory cytokines, interleukin (IL)‐17 and IL‐23 are elevated in psoriasis patients.ObjectivesTo investigate the incidence of biomarkers namely, HLA‐C*06:02, SNV's (rs30187, rs27044, rs2248374), and IL17 and IL23 as possible diagnostic/prognostic biomarkers of value, individually or in combination in psoriasis patients.MethodsThese biomarkers, HLA‐C*06:02, SNV's (rs3018, rs27044, rs2248374), and IL17 and IL23 (and their ratio) were tested in a cohort of 40 psoriasis patients attending a dermatology clinic situated in a tertiary academic hospital as well as 40 healthy controls by: HLA typing using sequence‐specific primers (PCR SSP), real time PCR, and Luminex technology, respectively.ResultsHLA‐C*06:02 was significantly elevated in our patient cohort with 53% (n = 21) of psoriasis patients expressing the HLA‐C*06:02 allele versus 15% (n = 6), p = 0.001 in the healthy controls. Both IL‐17 and IL‐23 were significantly elevated in the psoriasis patients compared to the normal controls (p = 0.0001 and p = 0.0005, respectively). The SNV rs2248374 showed an association with both IL‐17 and HLA‐C*06:02 in patients with psoriasis.ConclusionsOverall, these novel findings are the first to be published for South African and African populations in the public health sector. The finding of the current study corroborates international studies. Further validation through geographic and population expansion may assist in identifying individuals at risk of disease progression in psoriasis. These biomarkers may be used as potential prognosticators which will offer the opportunity for early medical intervention to reduce the burden of disease.
Knowledge management capability and outbound open innovation: Unpacking the role of desorptive capacity
Authors: Joseph Nidheesh 
Published: June 2023

AbstractAs firms seek multiple pathways for growth and competitiveness, effectively commercialising internal technologies leads to outbound open innovation. Both absorptive capacity and desorptive capacity are knowledge management capabilities crucial for open innovation. While absorptive capacity is well explored by researchers, studies around desorptive capacity are scarce. This study addresses recent calls for a more in‐depth exploration of the role of desorptive capacity, which is still in its cradle stage. Firstly, a synthesis of the literature on desorptive capacity was conducted from related fields like open innovation, external knowledge exploitation, technology transfer, technology commercialisation, and so on. Then, based on the synthesis, a theoretical framework was formulated to explain the role of desorptive capacity in enabling firms to identify, transfer and commercialise their internal technology outside their firm boundaries. Testable propositions were formulated around the role, antecedents and consequences of desorptive capacity. The findings were discussed along with a comparison between absorptive and desorptive capacities. The implications for both theory and practice are listed. The paper concludes by enumerating the limitations of this study and offering future research directions.