bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptome analysis reveals genes connected to temperature adaptation in juvenile antarctic krill Euphausia superba
Authors: Liu Yongliang , Li Lingzhi , Yang Jialiang , Huang Hongliang , Song Wei 
Published: June 2023

Abstract
Background
The Antarctic krill, Euphausia superba (E. superba), is a key organism in the Antarctic marine ecosystem and has been widely studied. However, there is a lack of transcriptome data focusing on temperature responses.

Methods
In this study, we performed transcriptome sequencing of E. superba samples exposed to three different temperatures: −1.19 °C (low temperature, LT), − 0.37 °C (medium temperature, MT), and 3 °C (high temperature, HT).

Results
Illumina sequencing generated 772,109,224 clean reads from the three temperature groups. In total, 1,623, 142, and 842 genes were differentially expressed in MT versus LT, HT versus LT, and HT versus MT, respectively. Moreover, Kyoto Encyclopedia of Genes and Genomes analysis revealed that these differentially expressed genes were mainly involved in the Hippo signaling pathway, MAPK signaling pathway, and Toll−like receptor signaling pathway. Quantitative reverse-transcription PCR revealed that ESG037073 expression was significantly upregulated in the MT group compared with the LT group, and ESG037998 expression was significantly higher in the HT group than in the LT group.

Conclusions
This is the first transcriptome analysis of E. superba exposed to three different temperatures. Our results provide valuable resources for further studies on the molecular mechanisms underlying temperature adaptation in E. superba.
Dairy and Plant-Based Milks: Implications for Nutrition and Planetary Health
Authors: Ramsing Rebecca , Santo Raychel , Kim Brent F. , Altema-Johnson Daphene , Wooden Alyssa , Chang Kenjin B. , Semba Richard D. , Love David C. 
Published: June 2023

Abstract
Purpose of Review
Dairy milk products are dominant in the market; however, plant-based milks are gaining prominence among USA consumers. Many questions remain about how plant-based milk products compare to dairy milk from a nutrition, public health, and planetary health perspective. Here, we compare the retail sales, nutrient profiles, and known health and environmental impacts of the production and consumption of dairy and plant-based milks and identify knowledge gaps for future studies. For our plant-based milk comparisons, we reviewed almond, soy, oat, coconut, rice, pea, cashew, and other plant-based milks as data were available.

Recent Findings
The retail unit price of plant-based milks was generally higher than that of cow’s milk, making it less accessible to lower-income groups. Many plant-based milks are fortified to match the micronutrient profile of dairy milk more closely. Notable differences remained, especially in protein, zinc, and potassium, depending on the base ingredient and individual product. Some plant-based milks contain added sugar to improve flavor. Plant-based milks were generally associated with lower environmental impacts (e.g., greenhouse gas emissions, water use) than cow’s milk, with the notable exception of the higher water footprint of almond milk.

Summary
This review of recent studies and consumer purchases confirmed that retail sales of plant-based milks are increasing and shifting among products. Further research is needed to better characterize the environmental impacts of newer plant-based milks, such as cashew, hemp, and pea milks; consumer attitudes and behavior towards plant-based milks; and the safety and potential health effects related to their long-term and more frequent consumption.
The causal nexus between bank indices and geopolitical risk: bootstrap causality analysis under horizontal sector dependence
Authors: Yıldırım Hakan , Şahin Eyyüp Ensari , Akdağ Saffet , Alola Andrew Adewale 
Published: June 2023

AbstractAs the global economy thrives and pushes for sustainable growth, there are also a plethora of non-economic challenges arising from the respective dimensions of insecurity and geopolitical tensions such as inter- and intra-country conflicts. Geopolitical risk mostly arises from security tensions, war, and terrorist incidents, which hamper peaceful inter-country and regional cooperation, thus endangering state institutions such as financial institutions. Given this observation, the current study examines the relationship between the geopolitical risk index and bank indices by employing the bootstrap panel causality approach over a monthly period from September 2003 to December 2018. In this case, the causality analysis of the geopolitical risk index and bank indices for six (6) countries (China, Indonesia, Israel, Philippines, Saudi Arabia, and Turkey) was performed. Importantly, the investigation found causality only from the geopolitical risk index to bank indices in Turkey and Israel. Given the statistical evidence from the study, we offer related policy recommendations, especially for the examined countries.
Assessment of the Impact of the Rotavirus Vaccine Against Severe Rotaviral Diarrhea in Uzbekistan
Authors: Musabaev Erkin , Ismailov Umed , Ibadullaeva Nargiz , Khikmatullaeva Aziza , Norbaev Ilham , Primov Umar , Ahrarova Dilorom , Sharapov Saidkhon , Yusupov Ulugbek , Latipov Renat 
Published: June 2023

Abstract
Background
This article presents the results of a long-term study of the impact of rotavirus vaccination in Uzbekistan. Uzbekistan is the first country in the Central Asian region to introduce rotavirus vaccination into the national compulsory vaccination calendar. The study aimed to evaluate the impact of rotavirus vaccination on hospitalizations due to all-cause AGE and RVGE in children < 5 years of age in Uzbekistan.

Methods
Detection of rotavirus antigen was performed using Rotavirus-Antigen-IFA-BEST "Vector Best" kit (Novosibirsk, Russia).

Results
The total of 20,128 children under 5 years of age were hospitalized in sentinel hospitals with a diagnosis of acute gastroenteritis during the study period (2019–2020). Of this number of children, 4481 children (22.2%) were included in the study. Of 4481 children, 367 (8.2%) children tested positive for rotavirus. In our study, decrease in the rotavirus rate was noted in all age groups. The peak of rotavirus positivity occurred in the months of January and February.

Conclusion
The average rotavirus-positive rate in the period (2019–2020) was 8.2% and the absolute percentage decrease was 18.1% compared to the pre-vaccination period (2005–2009) where the rotavirus-positive rate was 26.3%. The percentage of prevented cases averaged 68.8%.
Enhanced Continental Weathering as a Trigger for the End‐Devonian Hangenberg Crisis
Authors: Qie Wenkun , Zhang Junpeng , Luo Genming , Algeo Thomas J. , Chen Bo , Xiang Lei , Liang Kun , Liu Xianyi , Pogge von Strandmann Philip A. E. , Chen Jitao , Wang Xiangdong 
Published: June 2023

AbstractThe Hangenberg Crisis coincided with a large decline of biodiversity and widespread anoxia in the end‐Devonian ocean. Previous research attributed marine anoxia to the spread of deeply‐rooted plants and/or increased volcanism on the continents, but crucial links have not been thoroughly explored. Herein, we propose enhanced weathering as a key trigger, as evidenced by a negative shift (∼8‰) in lithium isotopes and a coupled response in carbon isotopes of marine carbonates in South China. Our findings imply that rapid weathering of crustal rocks increased nutrient delivery to the ocean, as indicated by an increase in the carbonate‐associated phosphate levels, contributing to oceanic eutrophication. In the absence of massive volcanic emissions and intense orogeny, the cause of enhanced continental weathering was likely the expansion of the terrestrial rhizosphere, highlighting the potential for land plant evolution to initiate weathering changes of sufficient severity to trigger a major bio/environmental crisis in the Earth system.
Influence of Land–Atmosphere Coupling on Low Temperature Extremes Over Southern Eurasia
Authors: Qi Yajing , Chen Haishan , Zhu Siguang 
Published: June 2023

AbstractLand–atmosphere coupling is a crucial factor influencing extreme weather and climate. Based on the ERA5‐Land reanalysis data set and sensitivity experiments with the CESM1.2.2 model, this study investigated the possible impacts of land–atmosphere coupling on low temperature extremes (LTEs) during fall and winter over southern Eurasia (SEA). The results suggested that LTEs show evident interdecadal variations in recent 60 years (1958–2017) and exhibit significant positive correlations with soil moisture anomalies based on the ERA5‐Land data set. Numerical simulations (the control run and sensitivity run with prescribed climatological soil moisture) isolated the effects of soil moisture‐related land surface processes and demonstrated that land–atmosphere coupling explains around 70% of temperature variability, increases the near‐surface air temperature by 0.81 K, and favors the reduction of LTEs by 8.20 d·yr−1. In the perturbation scenarios, the impacts of coupling on the frequency and spatial coverage of LTEs are more prominent. Further analysis revealed that the thermal cooling anomalies induced by the coupling could alter the atmospheric circulation, thereby affecting the frequency and intensity of LTEs. When the land–atmosphere interactions are weakened, the surface latent heat flux increases accompanied by intense evapotranspiration, while the sensible heat flux and net infrared radiation decrease. Land surface cooling is apparent, and it weakens with increasing altitude, along with geopotential height anomalies that are positive in the lower troposphere and weaker at higher altitudes. The northeasterly wind anomalies over the East European Plain facilitate the development of cold advection, providing a favorable circulation background for the generation of LTEs over SEA.
Enhanced Influence of Tropical Pacific Sea Surface Temperature Anomalies on Spring Extreme Heat Events Over Mid‐High Latitude Eurasia
Authors: Liu Sichang , Sun Jianqi 
Published: June 2023

AbstractThis study presents an interdecadal enhancement in the interannual relationship between spring extreme heat events (EHEs) over mid‐high latitude Eurasia and winter sea surface temperature (SST) over the tropical central‐eastern Pacific (TECP) after the late 1990s. Comparative analyses of the two subperiods before and after the late 1990s show that the interdecadal changes in the winter TECP SST could be responsible for such changeable relationship. After the late 1990s, the winter TECP SST anomalies (SSTA) feature a central Pacific (CP)‐type pattern. The CP‐type SSTA cause an anticyclone anomaly over the North Atlantic through the Pacific‐North American‐like teleconnection, further leading to a dipole SST pattern over the tropical to mid‐latitude North Atlantic. The CP‐type SSTA and North Atlantic dipole SSTA persist well from winter to spring, and the North Atlantic dipole SSTA favor the propagation of the CP‐type SST‐excited Rossby wave train to Eurasia in spring. Therefore, the TCEP SSTA have a significant interannual relationship with the spring Eurasian atmospheric circulations and EHEs after the late 1990s. The above physical processes are further confirmed by the SSTA sensitivity numerical experiments. In contrast, before the late 1990s, the winter TECP SSTA show an eastern Paciﬁc‐type pattern, which is related to weak and insignificant North Atlantic SSTA and spring Eurasian atmospheric circulations; consequently, the TCEP SSTA have a weak relationship with the EHEs variations during this period. The TCEP SSTA with one season leading can provide valuable information for the prediction of spring Eurasian EHEs variations in the recent two decades.
Utilizing Helium Ion Chemistry to Derive Mixing Ratios of Heavier Neutral Species in Saturn's Equatorial Ionosphere
Authors: Dreyer Joshua , Vigren Erik , Johansson Fredrik L. , Waite J. Hunter 
Published: June 2023

AbstractA surprisingly strong influx of organic‐rich material into Saturn's upper atmosphere from its rings was observed during the proximal obits of the Grand Finale of the Cassini mission. Measurements by the Ion and Neutral Mass Spectrometer (INMS) gave insights into the composition of the material, but it remains to be resolved what fraction of the inferred heavy volatiles should be attributed as originating from the fragmentation of dust particles in the instrument versus natural ablation of grains in the atmosphere. In the present study, we utilize measured light ion and neutral densities to further constrain the abundances of heavy volatiles in Saturn's ionosphere through a steady‐state model focusing on helium ion chemistry. We first show that the principal loss mechanism of He+ in Saturn's equatorial ionosphere is through reactions with species other than H2. Based on the assumption of photochemical equilibrium at altitudes below 2,500 km, we then proceed by estimating the mixing ratio of heavier volatiles down to the closest approaches for Cassini's proximal orbits 288 and 292. Our derived mixing ratios for the inbound part of both orbits fall below those reported from direct measurements by the INMS, with values of ∼2 × 10−4 at closest approaches and order‐of‐magnitude variations in either direction over the orbits. This aligns with previous suggestions that a large fraction of the neutrals measured by the INMS stems from the fragmentation of infalling dust particles that do not significantly ablate in the considered part of Saturn's atmosphere and are thus unavailable for reactions.
Temporal Variability of Fluvial Sand Composition: An Annual Time Series From Four Rivers in SW Germany
Authors: Stutenbecker L. , Scheuvens D. , Hinderer M. , Hornung J. , Petschick R. , Raila N. , Schwind E. 
Published: June 2023

AbstractThe sampling of fluvial sediment is subject to many sources of uncertainty, for example, time and location, and the number of samples collected. It is nevertheless commonly assumed that a sample taken at one time and location provides a somewhat averaged compositional signal. Any spatial or temporal variability of this signal is often neglected. This study investigates how the composition of bed load sand changes over an observation period of 1 year in four river basins with differing bedrock geology in southwestern Germany. Up to 12 bulk sediment samples were taken at the same locations using the same approach and analyzed for their granulometry and geochemistry. The results indicate that (a) different grain sizes yield different compositions due to source rock composition and hydraulic sorting effects, (b) bulk sediment composition changes temporally due to changing grain‐size distribution, and (c) compared to the bulk sample, the composition of narrow grain sizes is temporally more stable but nevertheless has an average variability of 15%. Because heavy mineral‐bound elements such as Zr have the highest variability, we relate a major component of compositional variability to temporally varying heavy mineral concentrations in response to hydrodynamic processes. Mixing modeling demonstrates that the fluvial sand faithfully reflects its catchment geology and that the sediment sources do not change substantially during the observation period, even during a flooding event. We conclude (a) that the causes for compositional variability may be disentangled using chemical and granulometric time series data and (b) that narrow grain sizes yield representative source rock contributions.
The effect of ketamine on synaptic mistuning induced by impaired glutamate reuptake
Authors: Vazquez-Juarez Erika , Srivastava Ipsit , Lindskog Maria 
Published: June 2023

AbstractMistuning of synaptic transmission has been proposed to underlie many psychiatric disorders, with decreased reuptake of the excitatory neurotransmitter glutamate as one contributing factor. Synaptic tuning occurs through several diverging and converging forms of plasticity. By recording evoked field postsynaptic potentials in the CA1 area in hippocampal slices, we found that inhibiting glutamate transporters using DL-TBOA causes retuning of synaptic transmission, resulting in a new steady state with reduced synaptic strength and a lower threshold for inducing long-term synaptic potentiation (LTP). Moreover, a similar reduced threshold for LTP was observed in a rat model of depression with decreased levels of glutamate transporters. Most importantly, we found that the antidepressant ketamine counteracts the effects of increased glutamate on the various steps involved in synaptic retuning. We, therefore, propose that ketamine’s mechanism of action as an antidepressant is to restore adequate synaptic tuning.
Metabolomics signatures of depression: the role of symptom profiles
Authors: de Kluiver Hilde , Jansen Rick , Penninx Brenda W. J. H. , Giltay Erik J. , Schoevers Robert A. , Milaneschi Yuri 
Published: June 2023

AbstractDepression shows a metabolomic signature overlapping with that of cardiometabolic conditions. Whether this signature is linked to specific depression profiles remains undetermined. Previous research suggested that metabolic alterations cluster more consistently with depressive symptoms of the atypical spectrum related to energy alterations, such as hyperphagia, weight gain, hypersomnia, fatigue and leaden paralysis. We characterized the metabolomic signature of an “atypical/energy-related” symptom (AES) profile and evaluated its specificity and consistency. Fifty-one metabolites measured using the Nightingale platform in 2876 participants from the Netherlands Study of Depression and Anxiety were analyzed. An ‘AES profile’ score was based on five items of the Inventory of Depressive Symptomatology (IDS) questionnaire. The AES profile was significantly associated with 31 metabolites including higher glycoprotein acetyls (β = 0.13, p = 1.35*10-12), isoleucine (β = 0.13, p = 1.45*10-10), very-low-density lipoproteins cholesterol (β = 0.11, p = 6.19*10-9) and saturated fatty acid levels (β = 0.09, p = 3.68*10-10), and lower high-density lipoproteins cholesterol (β = −0.07, p = 1.14*10-4). The metabolites were not significantly associated with a summary score of all other IDS items not included in the AES profile. Twenty-five AES-metabolites associations were internally replicated using data from the same subjects (N = 2015) collected at 6-year follow-up. We identified a specific metabolomic signature—commonly linked to cardiometabolic disorders—associated with a depression profile characterized by atypical, energy-related symptoms. The specific clustering of a metabolomic signature with a clinical profile identifies a more homogenous subgroup of depressed patients at higher cardiometabolic risk, and may represent a valuable target for interventions aiming at reducing depression’s detrimental impact on health.
Wear effects between polymethyl methacrylate occlusal splints and opposing dentin surfaces during bruxism mimicking events
Authors: Potewiratnanond Prangtip , Ekrojanakul Cholakorn , Harikul Tatcharee , Kositvanich Rapatporn 
Published: June 2023

Abstract
Objectives
To compare the surface wear rate between polymethyl methacrylate (PMMA)-based occlusal splints and opposing dentin-exposed teeth in bruxism simulating models.

Materials and methods
PMMA-based occlusal splints and extracted premolars were tested on a chewing stimulator at 30,000 or 60,000 cycles. Dentin wear was measured under a stereomicroscope and PMMA wear was determined with an optical profilometer. In addition, wear surface topography was assessed and quantified by scanning electron microscopy (SEM).

Results
Wear rate of PMMA was significantly greater (11 times) than that of dentin specimens at 60,000 cycles, though these findings were not observed at 30,000 cycles. When comparing wear rates within each group at different duration cycles, PMMA surfaces exhibited an average wear rate 1.4 times higher with high duration cycles, while dentin surfaces displayed a marginal decrease in wear. In SEM micrographs, PMMA surfaces displayed more wear abrasion lines with higher duration cycles. However, dentin surfaces did not exhibit major differences between low and high duration cycles.

Conclusion
Wear rate on PMMA-based occlusal splints remarkably increases upon high chewing cycles mimicking bruxism comparing with the rate on dentin. Hence, it is reasonable for bruxing patients to wear single-arch PMMA-based occlusal splints to protect opposing dentin-exposed teeth.
Global warming accelerates soil heterotrophic respiration
Authors: Nissan Alon , Alcolombri Uria , Peleg Nadav , Galili Nir , Jimenez-Martinez Joaquin , Molnar Peter , Holzner Markus 
Published: June 2023

AbstractCarbon efflux from soils is the largest terrestrial carbon source to the atmosphere, yet it is still one of the most uncertain fluxes in the Earth’s carbon budget. A dominant component of this flux is heterotrophic respiration, influenced by several environmental factors, most notably soil temperature and moisture. Here, we develop a mechanistic model from micro to global scale to explore how changes in soil water content and temperature affect soil heterotrophic respiration. Simulations, laboratory measurements, and field observations validate the new approach. Estimates from the model show that heterotrophic respiration has been increasing since the 1980s at a rate of about 2% per decade globally. Using future projections of surface temperature and soil moisture, the model predicts a global increase of about 40% in heterotrophic respiration by the end of the century under the worst-case emission scenario, where the Arctic region is expected to experience a more than two-fold increase, driven primarily by declining soil moisture rather than temperature increase.
A flavin-monooxygenase catalyzing oxepinone formation and the complete biosynthesis of vibralactone
Authors: Feng Ke-Na , Zhang Yue , Zhang Mingfang , Yang Yan-Long , Liu Ji-Kai , Pan Lifeng , Zeng Ying 
Published: June 2023

AbstractOxepinone rings represent one of structurally unusual motifs of natural products and the biosynthesis of oxepinones is not fully understood. 1,5-Seco-vibralactone (3) features an oxepinone motif and is a stable metabolite isolated from mycelial cultures of the mushroomBoreostereum vibrans. Cyclization of3forms vibralactone (1) whose β-lactone-fused bicyclic core originates from 4-hydroxybenzoate, yet it remains elusive how 4-hydroxybenzoate is converted to3especially for the oxepinone ring construction in the biosynthesis of1. In this work, using activity-guided fractionation together with proteomic analyses, we identify an NADPH/FAD-dependent monooxygenase VibO as the key enzyme performing a crucial ring-expansive oxygenation on the phenol ring to generate the oxepin-2-one structure of3. The crystal structure of VibO reveals that it forms a dimeric phenol hydroxylase-like architecture featured with a unique substrate-binding pocket adjacent to the bound FAD. Computational modeling and solution studies provide insight into the likely VibO active site geometry, and suggest possible involvement of a flavin-C4a-OO(H) intermediate.