bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acromegaly in the differential diagnosis of hearing loss
Authors: Dzeranova L. K. , Lepeshkina L. I. , Shutova A. S. , Perepelova M. A. , Pigarova E. A. , Azizyan V. N. , Akopyan P. V. , Przhialkovskaya Е. G. , Melnichenko G. A. , Mokrysheva N. G. 
Published: May 2023

Acromegaly is a multifactorial neuroendocrine disease caused by hyperproduction of growth hormone (GH). In more than 95% of cases the reason of acromegaly the GH-secreting pituitary adenoma. In patients with this neuroendocrine disease, a slowly developing complex of symptom can manifest with concomitant pathological conditions, including auditory function disordersDiagnostic difficulties of acromegaly at the ambulatory stage determine the importance of doctor`s awareness in different medical specialties.Here we demonstrate a clinical case of the improvement of the auditory function due to combined surgical and medical treatment of a patient with the pituitary macroadenoma, acromegaly and hearing loss.Anamnesis features: a patient with an active stage of acromegaly and a pituitary macroadenoma measuring 57x35x32 mm with ante-, supra-, infra-, parasellar spread, (Knosp III(D), Knosp IV(S) noted a violation of auditory function. She was consulted by an otolaryngologist, sensorineural hearing loss on the right of the 3rd degree was diagnosed, on the left of the 1st degree. The patient underwent surgical treatment of pituitary adenoma, noted a significant improvement in auditory function in the early postoperative period. Six months later, repeated audiometry was performed, marked regression of hearing damage was noted.The case described by us indicates the reversibility of a rare complication of acromegaly — hearing loss and the importance of an interdisciplinary approach in the management of patients with this pathology.
Неоднородность населения по числу рожденных детей: существует ли «порядковый переход»?
Authors: Калабихина Ирина Евгеньевна , Кузнецова Полина Олеговна 
Published: May 2023

В работе исследуется динамика неоднородности населения по числу рожденных детей разных порядков в странах с уровнем рождаемости ниже простого воспроизводства для когорт женщин 1960-1980-х годов рождения и ранее. Неоднородность рождаемости оценивается с помощью распределения женщин по порядкам рождений, вероятностей рождения детей определенных порядков, а также трех индексов концентрации рождаемости. В качестве эмпирической базы исследования используются данные Human Fertility Database для 18 стран.
Авторы показывают существование так называемого порядкового перехода, который выражается в двух стадиях — последовательное снижение и рост неоднородности по числу рожденных детей разных порядков, и изучают, за счет каких порядков изменяется неоднородность на этих стадиях. Анализ данных для пяти стран с длинным рядом наблюдений показал, что первая стадия может ассоциироваться с отказом от рождений высоких порядков, а вторая стадия — с ростом бездетности. Авторы отмечают, что в будущем этот вывод должен быть подкреплен большим числом наблюдений.
Кроме того, в работе подтверждается наличие «восточноевропейской» и «западноевропейской» моделей рождаемости в контексте динамики неоднородности населения по числу рожденных детей. «Восточноевропейская» модель рождаемости сохраняется даже в процессе роста неоднородности населения, наблюдаемого для поколений второй половины 1970-х годов рождения; ее отличает относительно низкий уровень неоднородности населения по числу рожденных детей разных порядков, а также менее глубокие изменения неоднородности в процессе «порядкового перехода».
Благодарность. Авторы благодарят двух анонимных рецензентов, чьи комментарии позволили существенно доработать текст.
Исследование проведено при финансовой поддержке Госзадания МГУ № 122041800047-9 «Воспроизводство населения в социально-экономическом развитии».
The Impact of Product-Dependent Policyholder Risk Sensitivities in Life Insurance: Insights from Experiments and Model-Based Simulation Analyses
Authors: Gatzert Nadine , Hanika Moritz 
Published: May 2023

Abstract
In contrast to previous work, this paper studies the product-dependent risk sensitivities of policyholders toward the reported safety levels of a life insurer in a long-term multi-period setting. With this aim, we first conduct two choice-based conjoint analyses using a German survey panel to investigate the effect of an insurer’s reported default probability on individuals’ willingness to pay for annuities and term life insurances. Our experimental results suggest that individuals (sharply) reduce their willingness to pay for probabilistic life insurance products, with (strong) product-specific differences. In light of these observations, the paper then revisits the impact of these differing risk sensitivities on a life insurer’s risk situation in a simulation study based on an asset-liability model with a specific focus on a life insurer offering annuities and term life insurances. The results reveal the potentially strong impact of such product-dependent risk sensitivities on risk-reducing portfolio compositions. One main driver is the deviation between risk sensitivities depending on the respective product (annuities vs. term life).
Safety monitoring of drug-induced muscle injury and rhabdomyolysis: a biomarker-guided approach for clinical practice and drug trials
Authors: Ostrowski Patryk , Bonczar Michał , Avram Aida-Elena , Lippi Giuseppe , Henry Brandon M. 
Published: May 2023

Abstract
Skeletal muscle tissue (SKM) may be damaged due to mechanical, metabolic, and exertional causes. However, drug-induced myopathy is among the most frequent causes of muscle disease. The clinical picture of drug-induced myopathies may be highly variable. It may present as asymptomatic or mild myalgias, with or without muscle weakness, which are likely underreported. However, it may also appear as chronic myopathy with severe weakness and, rarely, even as massive rhabdomyolysis with acute kidney injury (AKI). Unfortunately, the available biomarkers for SKM injury do not fully meet the needs for satisfactory detection of drug-induced damage, both in clinical and research settings, mainly due to their low sensitivity and specificity. Therefore, the present study proposes a strategy for drug safety monitoring using the available biomarkers of SKM injury. Moreover, we will discuss mechanisms of drug-induced SKM injury, traditional laboratory testing for SKM injury, and novel skeletal myocyte biomarkers under investigation. This can be incredibly useful in both clinical practice and for de-challenge/re-challenge investigational trials where the risk of drug-induced SKM injury is present.
Discourse competence across band scores: an analysis of speaking performance in the General English Proficiency Test
Authors: Lin Yen-Liang , Tsai Yu-Chan , Hsieh Chen-Yu Chester 
Published: May 2023

Abstract
While discourse competence (DC) has been identified as the core competence in English as a foreign language (EFL) learning and communication, only a few empirical studies have focused on DC in speaking assessments. This study investigates the discourse features (i.e., cohesion and coherence) of Taiwanese candidates’ performances in an argumentative exposition task in the General English Proficiency Test (GEPT) by analyzing the construction of cohesion and coherence across four band scores (i.e., Bands 2, 3, 4, and 5). Cohesion analysis showed that all the three types of cohesion devices (i.e., grammatical, logical, and lexical) develop linearly with increasing band score levels. The higher-score test-takers (Bands 4 and 5) adopted grammatically and semantically more appropriate references to establish an accurate relation with the referents. They also tended to use a higher frequency of overall conjunctions (particularly additive) and repetition to promote logical and lexical cohesion. Coherence analysis found that high-score candidates were more equipped to produce a response that complies with the expected generic structure of argumentative tasks. While more complex theme-rheme patterns appeared more frequently in the discourse of higher-score candidates, theme reiteration patterns were only observed in Band 2. These results illustrate how Taiwanese EFL learners demonstrate DC with cohesive and coherence strategies in speaking test performance across band scores. Pedagogical implications for language teaching and learning are then discussed.
Does hydrotherapy influence plasma glucose levels in type 2 diabetes? – A scoping review
Authors: Chidambaram Yogapriya , Vijayakumar Venugopal , Ravi Poornima , Boopalan Deenadayalan , Anandhan Akila , Kuppusamy Maheshkumar 
Published: May 2023

Abstract

Background
Hydrotherapy is a commonly used treatment modality to manage various conditions including diabetes in the Naturopathy system of medicine. The objective of the current scoping review is to find the effectiveness of hydrotherapy on plasma blood glucose levels in type 2 diabetes.

Content
Arksey and O’Malley’s five-stage framework was adopted for this scoping review. The studies which used hydrotherapy intervention for the management of diabetes or the effect of hydrotherapy on plasma glucose levels were considered eligible. PubMed/MEDLINE, EMBASE, Cochrane library, and Google scholar were searched for English- language published articles till December 20, 2022. The following Medical Subject Headings (MeSH) and keyword search terms were used (“diabetes” OR “type 2 diabetes” OR “diabetes mellitus” OR “plasma glucose level”) AND (“hydrotherapy” OR “water therapy” OR “balneotherapy”). Two investigators independently assessed the studies for inclusion. Review articles, abstracts, and articles including the aquatic exercises as interventions were excluded.

Summary
In total, six studies met the inclusion criteria. Out of six, two studies used hot therapies, two studies cold therapy, and the remaining two used both hot and cold as interventions. The study results showed that hydrotherapy can be used as an effective intervention tool for blood glucose levels in patients with type 2 diabetes.

Outlook
Integrating hydrotherapy treatments alongside conventional management can reduce blood glucose levels and thus reduce diabetes-related complications.
New records of Myotis bakeri (Chiroptera: Vespertilionidae), and preliminary evidence of a new zoogeographic pattern
Authors: Llancachahua-Tarqui Daniel , Sánchez-Vendizú Pamela , Pacheco Víctor 
Published: May 2023

Abstract

Myotis bakeri is a Peruvian endemic bat with little information about its natural history and geographic distribution. Based on a revision of museum specimens, we report new records of M. bakeri extending its distribution range 143 km northwest and 98 km southeast. Also, the elevational range is extended to 1445 m. The current allopatric distribution of M. bakeri and M. atacamensis, and other bat species, suggests the existence of two unreported bat assemblages in the Peruvian western slope.
TiO2 aerogel composite high-efficiency photocatalysts for environmental treatment and hydrogen energy production
Authors: Long Xin , Wei Xiongbang , Qiu Yuhong , Song Yaochen , Bi Linnan , Tang Pengkai , Yan Xingbin , Wang Sizhe , Liao Jiaxuan 
Published: May 2023

Abstract
Photocatalysis is a new type of renewable energy technology used in environmental treatment and hydrogen energy production. In this regard, a new class of photocatalysts, TiO2 aerogels, are attractive for having the chemical characteristics of TiO2 nanomaterials such as high catalytic activity, good stability, non-toxic, and non-polluting, and the structural characteristics of aerogels such as large specific surface area, high porosity, the 3-dimensional interconnected network structure composed of relatively uniform nanoparticles, and high light transmittance. Here we review the recent progress in TiO2 aerogels for photocatalysis, focusing on preparation techniques, the crystalline phases’ influence on photocatalytic properties, the modification of photocatalytic properties, and the analysis and discussion of future development. In particular, we first summarize various preparation techniques, including sol–gel method, nanoparticles self-assembly synthesis, and high-temperature aerosol technique, then detail the structure and composition of TiO2 crystalline phases that affect the photocatalytic properties. Subsequently, we discuss strategies to further enhance the photocatalytic properties of TiO2 aerogels by the composite of SiO2 aerogel semiconductors, the doping of metal dopants, and the doping or composite of non-metallic substances, and elaborate the modification mechanism and the modification effect achieved. Finally, combined with the research status of TiO2 aerogels and the development experience of other aerogels, we conduct a reasonable analysis and discussion on their further research directions and industrialization roads.
Diffraction-based dual path multispectral imaging
Authors: Haist Tobias , Hahn Robin , Reichelt Stephan 
Published: May 2023

Abstract
Diffraction based multispectral imaging is a method for obtaining snapshot multispectral image information by using a structured diffraction grating or computer-generated hologram in an intermediate image plane of an imaging system. Without the need of complicated filter manufacturing it becomes possible to realize application specific spatio-spectral sampling of an image. The spectral resolution is coupled with the spatial resolution because the central stop of the imaging system serves also as the main spectral filtering component. By using two image sensors and the zeroth order of the computer-generated holograms it becomes possible to obtain high resolution spatial information as well as spectral information on a coarser sampling grid.
Experimental investigation on a Jeffcott rotor with combined coupling misalignment using time-frequency analysis
Authors: Kumar Ashutosh , Sathujoda Prabhakar , Bhalla Neelanchali Asija 
Published: May 2023

Abstract
Rotating machinery, such as turbo-jet engines, operate at a high rotational speed and passes through critical zones. The dynamic response of high-speed machines is critical for long-term stability and functioning. In this work, a fast and effective method for detecting coupling misalignment utilising time-frequency analysis (TFA) based on both the adaptive noise added complete ensemble empirical mode decomposition and wavelet-based denoising is presented. This novel and innovative method detect the coupling misalignment feature via the amplitude modulation aspect in the envelope analysis of the fault-containing intrinsic mode function. The Hilbert spectrum analysis provides spontaneous frequency and spectral energy in the time-frequency domain. The experiments were performed for various rotor accelerations and combined parallel and angular coupling misalignments using a laboratory test rig. The suggested approach gives excellent denoising efficiency and can improve misalignment identification accuracy. Additionally, it may be highly helpful for machinery that starts and stops often.
The Felled Tree – metaphor and theology
Authors: Golan Naama 
Published: May 2023

Abstract
The article demonstrates the connection between metaphor and theology and shows how, by tracing the development of the metaphor of the felled tree and its regrowth, it is possible to point to the development of certain theological trends. It argues that Nebuchadnezzar’s dream of the tree in Daniel (3:31–4:34) serves as an »inner-biblical interpretation« for the prophecy regarding the »shoot from the stump of Jesse« (Isaiah 10:33–11:9), identifying three stages in the development of the metaphor of the felled tree.
Lieferkettengesetz ist im Januar in Kraft getreten
Authors: Drexl Claus 
Published: May 2023

Abstract
Mit dem neuen Lieferkettengesetz will der Gesetzgeber die Verantwortung für Lieferketten in Unternehmen verankern und damit angesichts komplexer Supply Chains Menschen- und Umweltrechte weltweit besser schützen. Auf Unternehmen kommt damit ein Paket neuer Verantwortlichkeiten mit Risikomanagement, Risikoanalyse sowie Sorgfaltspflichten wie Beschwerdeverfahren, Prävention und Abhilfe zu – samt Dokumentation und regelmäßiger Überprüfung. Wer diesen Anforderungen alleine nicht nachkommen kann, kann externe Dienstleistungsangebote nutzen, um seine gesetzlichen Pflichten zu erfüllen.
Private 5G-Campusnetze für den industriellen Einsatz in der Intralogistik
Authors: Lackner Thorge , Kuhn Christian , Hermann Julian , Dietrich Fabian , Palm Daniel 
Published: May 2023

Abstract
5G-Campusnetze sind vielversprechende Umgebungen für industrielle Anwendungen in Produktion und Intralogistik. Diese erreichen jedoch bisher nicht die versprochenen Leistungen, um intralogistischen Anwendungen das volle Potenzial von 5G bieten zu können. Die im Rahmen des Projekts 5G4KMU erhobenen und in diesem Beitrag vorgestellten Leistungsmessungen dienen zur Evaluierung der derzeitigen Praxistauglichkeit von 5G-Campusnetzen.
KI-Engineering für die Produktion im Kontext von Datenräumen
Authors: Usländer Thomas 
Published: May 2023

Abstract
KI-Projekte in der industriellen Produktion führen sehr oft nur zu Prototypen oder zu Demonstratoren, obwohl diese zumeist vielversprechende Lösungskonzepte darstellen. Die aufkommende Disziplin des KI-Engineering adressiert diese Problematik über einen systematischen Engineering-Ansatz. Dieser Beitrag fokussiert auf die besondere Herausforderung der Bereitstellung von nutzbaren Daten, u. a. für maschinelle Lernverfahren, sei es innerhalb eines Unternehmens oder über branchenspezifische Datenräume.
Antiviral activity of the human endogenous retrovirus‐R envelope protein against SARS‐CoV‐2
Authors: Ansari Shabnam , Gupta Nidhi , Verma Rohit , Singh Oinam N , Gupta Jyoti , Kumar Amit , Yadav Mukesh Kumar , Binayke Akshay , Tiwari Mahima , Periwal Neha , Sood Vikas , Mani Shailendra , Awasthi Amit , Shalimar  , Nayak Baibaswata , Ranjith‐Kumar CT , Surjit Milan 
Published: May 2023

AbstractCoronavirus‐induced disease‐19 (COVID‐19), caused by SARS‐CoV‐2, is still a major global health challenge. Human endogenous retroviruses (HERVs) represent retroviral elements that were integrated into the ancestral human genome. HERVs are important in embryonic development as well as in the manifestation of diseases, including cancer, inflammation, and viral infections. Here, we analyze the expression of several HERVs in SARS‐CoV‐2‐infected cells and observe increased activity of HERV‐E, HERV‐V, HERV‐FRD, HERV‐MER34, HERV‐W, and HERV‐K‐HML2. In contrast, the HERV‐R envelope is downregulated in cell‐based models and PBMCs of COVID‐19 patients. Overexpression of HERV‐R inhibits SARS‐CoV‐2 replication, suggesting its antiviral activity. Further analyses demonstrate the role of the extracellular signal‐regulated kinase (ERK) in regulating HERV‐R antiviral activity. Lastly, our data indicate that the crosstalk between ERK and p38 MAPK controls the synthesis of the HERV‐R envelope protein, which in turn modulates SARS‐CoV‐2 replication. These findings suggest the role of the HERV‐R envelope as a prosurvival host factor against SARS‐CoV‐2 and illustrate a possible advantage of integration and evolutionary maintenance of retroviral elements in the human genome.
Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1
Authors: Li Tengteng , Fei Jiajia , Yu Huihui , Wang Xingxing , Li Dan , Yin Zongzhi 
Published: May 2023

In brief
During pregnancy, uterine kept quiescence along with uterine overdistention before labor. Prolonged stretching induced uterus myometrial hypoxia, increased TREK1 expression, and relaxed the myometrium, which may contribute to uterine quiescence and atony during pregnancy.

Abstract
The mechanisms underlying pre-labor uterine quiescence and uterine atony during overdistention are unclear. TREK1 (a two-pore domain potassium channel) and hypoxia-inducible factor-1α (HIF-1α) are activated by mechanical stretch, and their expression is upregulated by decreased uterine contractility. HIF-1α is a nuclear factor which regulates numerous target proteins, but whether it regulates TREK1 during the uterine stretch to cause uterine quiescence and/or atony is unclear. We investigated uterine contractility at different gestational stages in rats, as well as in non-pregnant uteri, which were induced by prolonged stretching and hypoxia. We also assessed the effects of incubating the uteri with or without echinomycin or l-methionine. Moreover, we analyzed HIF-1α and TREK1 expression levels in each group, as well as at various gestational stages of pregnant human uteri. We found that contractility was significantly decreased in pregnant uteri when compared with non-pregnant uteri, and this decrease was associated with increases in HIF-1α and TREK1 expression levels. HIF-1α and TREK1 expression levels in human uteri increased with the gestational length. Decreased uterine contractility and increased HIF-1α and TREK1 expression levels were also observed in non-pregnant rat uteri under 8 g of stretching tension or hypoxia. Inhibition of hypoxia with echinomycin restored normal uterine contractility, while HIF-1α and TREK1 protein expression remained reduced. TREK1 inhibition with l-methionine also restored uterine contractility under tension or hypoxia. In conclusion, we demonstrated that prolonged stretching induces myometrial hypoxia, increases TREK1 expression, and relaxes the myometrium, which may contribute to uterine quiescence and atony.
Transfer Timing and the Length of Medication Weaning for Neonatal Opioid Withdrawal Syndrome
Authors: Botticello Amanda L. , Chen Yu-Lun , Smith Melissa G. , Chung Alison Folliard , Marchetta Claire M. , McMahon Morgan , Van Orden Kara , Sulter Amber , Weinstein Lindsay , Zalewitz Jodi , O’Neill John 
Published: May 2023

OBJECTIVE
Many infants with neonatal opioid withdrawal syndrome (NOWS) from prenatal exposure to opioids require transfer to a pediatric inpatient unit for medication weaning. The purpose of this study is to assess the difference in the duration of medication weaning between infants transferred by day of life (DOL) 14 versus later (DOL 15 and after) to a tertiary care setting for pharmacological and nonpharmacological management of NOWS.

METHODS
This single-site retrospective cohort study uses medical chart data from infants with NOWS transferred to specialized care between May 2016 and June 2021 (n = 87). The primary outcome is length of medication weaning, calculated as the number of days between transfer from the NICU to a tertiary care setting and the cessation of pharmacotherapy.

RESULTS
The majority of the infants in this sample are transferred from acute to tertiary care after DOL 15 (62% versus 38% by DOL 14). The predicted number of days to wean is 14.2 among those infants transferred by DOL 14, whereas the duration of weaning is 6.6 days longer among the later transfer group (20.8 days), adjusting for key covariates. The duration of weaning is also prolonged among infants with greater NOWS symptom severity and with prenatal exposure to psychotropic medications.

CONCLUSIONS
Delayed treatment prolongs NOWS symptoms and increases the burden on the health care system. Earlier referral from NICUs to pediatric inpatient units with environmental supports could reduce prolonged medication exposure and length of hospitalization for infants diagnosed with NOWS.