bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell‐Laden Scaffolds for Vascular‐Innervated Bone Regeneration
Authors: Qin Chen , Zhang Hongjian , Chen Lei , Zhang Meng , Ma Jingge , Zhuang Hui , Huan Zhiguang , Xiao Yin , Wu Chengtie 
Published: February 2023

AbstractFor regeneration of highly vascularized and innervated tissues, like bone, simultaneous ingrowth of blood vessels and nerves is essential but largely neglected. To address this issue, a “pre‐angiogenic” cell‐laden scaffold with durable angiogenic functions is prepared according to the bioactivities of silicate bioceramics and the instructive effects of vascular cells on neurogenesis and bone repair. Compared with traditional cell‐free scaffolds, the prepared cell‐laden scaffolds printed with active cells and bioactive inks can support long‐term cell survival and growth for three weeks. The long‐lived scaffolds exhibited durable angiogenic capability both in vitro and in vivo. The pre‐angiogenic scaffolds can induce the neurogenetic differentiation of neural cells and the osteogenic differentiation of mesenchymal stem cells by the synergistic effects of released bioactive ions and the ability of vascular cells to attract neurons. The enhanced bone regeneration with both vascularization and innervation is attributed to these physiological functions of the pre‐angiogenic cell‐laden scaffolds, which is defined as “vascular‐innervated” bone regeneration. It is suggested that the concept of “vascular‐innervated scaffolds” may represent the future direction of biomaterials for complex tissue/organ regeneration.
Microneedle Patch for Painless Intradermal Collection of Interstitial Fluid Enabling Multianalyte Measurement of Small Molecules, SARS‐CoV‐2 Antibodies, and Protein Profiling
Authors: Ribet Federico , Bendes Annika , Fredolini Claudia , Dobielewski Mikolaj , Böttcher Michael , Beck Olof , Schwenk Jochen M. , Stemme Göran , Roxhed Niclas 
Published: February 2023

AbstractBlood sampling is a common practice to monitor health, but it entails a series of drawbacks for patients including pain and discomfort. Thus, there is a demand for more convenient ways to obtain samples. Modern analytical techniques enable monitoring of multiple bioanalytes in smaller samples, opening possibilities for new matrices, and microsampling technologies to be adopted. Interstitial fluid (ISF) is an attractive alternative matrix that shows good correlation with plasma concentration dynamics for several analytes and can be sampled in a minimally invasive and painless manner from the skin at the point‐of‐care. However, there is currently a lack of sampling devices compatible with clinical translation. Here, to tackle state‐of‐the‐art limitations, a cost‐effective and compact single‐microneedle‐based device designed to painlessly collect precisely 1.1 µL of dermal ISF within minutes is presented. The fluid is volume‐metered, dried, and stably stored into analytical‐grade paper within the microfluidic device. The obtained sample can be mailed to a laboratory, quantitatively analyzed, and provide molecular insights comparable to blood testing. In a human study, the possibility to monitor various classes of molecular analytes is demonstrated in ISF microsamples, including caffeine, hundreds of proteins, and SARS‐CoV‐2 antibodies, some being detected in ISF for the first time.
Deep Learning Enabled Early Predicting Cardiovascular Status Using Highly Sensitive Piezoelectric Sensor of Solution‐Processable Nylon‐11
Authors: Babu Anand , Ranpariya Spandan , Sinha Dhirendra Kumar , Chatterjee Arpitam , Mandal Dipankar 
Published: February 2023

AbstractCardiovascular diseases are found as one of the major cause of deaths globally, these can be reduced substantially if early‐stage detection and intervention is possible. Regular monitoring of the arterial pulse is one of the possible solutions, however, existing technologies have put limitations, due instability in continuous monitoring, lack of information in real‐time recording of cardiovascular parameters and bulky instruments. A highly sensitive flexible piezoelectric sensor of nylon‐11 fabricated is introduced from simple solution processable technique. Which consists of a highly sensitive, flexible, conformable piezoelectric film, owing to its high mechanosensitivity (≈225 mV N−1) in the subtle pressure range (0.001–1 kPa), and fast responsivity (≈4 ms), it is tested for assessing risk factors of cardiovascular diseases based on arterial pulse data. It is integrated with the internet of things (IoT) via system on a chip to facilitate remote healthcare monitoring. Deep learning algorithms is further interfaced with sensor for early detect and predict cardiovascular risks, showing an accuracy of >94% for predicting cardiovascular status. This piezoelectric sensor equipped with artificial intelligence and IoT has potential for monitoring the risk analysis of the cardiovascular diseases, daily activities, and facilitate to early predict the anomalous physiological changes in the body.
Brown Algal Residue for the Recovery of Metal Ions—Application to La(III), Cd(II), and Ni(II) Sorption
Authors: Ballesteros‐Plata Daniel , Zhang Yue , Rodríguez‐Castellón Enrique , Vincent Thierry , Guibal Eric 
Published: February 2023

AbstractRemoving hazardous metals and recovering valuable strategic metals from wastewater has become an important challenge for the industry. Herein, brown algal biomass residue (AR, after bio‐stimulant extraction, currently poorly valorized) is tested for the removal of Ni(II), Cd(II), and La(III) from aqueous solutions. This valorization of industrial waste makes profit of residual amounts of alginate‐based materials, which have a strong affinity for metal cations. Fourier transform infrared (FTIR) and X‐ray photoelectron spectroscopy (XPS) techniques are used for characterizing metal/biosorbent interactions. Uptake kinetics are relatively fast (equilibrium being reached in 180–240 min). The Sips equation fits the sorption isotherms; the maximum sorption capacities at pH ≈5 reach up to 0.84 mmol La g−1, 0.92 mmol Cd g−1, and 0.78 mmol Ni g−1. In binary solutions, AR shows marked preference for La(III) over divalent cations. This selectivity may be increased by complexing base metals with EDTA, opening the route for the selective recovery of rare earth elements. HCl solution reveals more efficient (>90% for La(III), ≈82% for Cd(II) and Ni(II)) than CaCl2 solution at pH 2 for metal desorption. This waste residue from biostimulant extraction (in brown algal biomass) can be valorized for the recovery of hazardous and strategic metal ions.
Rational Design of Mixed Matrix Membranes Modulated by Trisilver Complex for Efficient Propylene/Propane Separation
Authors: Cong Shenzhen , Feng Xiaoquan , Guo Lili , Peng Donglai , Wang Jing , Chen Jinghuo , Zhang Yatao , Shen Xiangjian , Yang Guang 
Published: February 2023

AbstractThe application of membrane‐based separation processes for propylene/propane (C3H6/C3H8) is extremely promising and attractive as it is poised to reduce the high operation cost of the established low temperature distillation process, but major challenges remain in achieving high gas selectivity/permeability and long‐term membrane stability. Herein, a C3H6 facilitated transport membrane using trisilver pyrazolate (Ag3pz3) as a carrier filler is reported, which is uniformly dispersed in a polymer of intrinsic microporosity (PIM‐1) matrix at the molecular level (≈15 nm), verified by several analytical techniques, including 3D‐reconstructed focused ion beam scanning electron microscropy (FIB–SEM) tomography. The π‐acidic Ag3pz3 combines preferentially with π‐basic C3H6, which is confirmed by density functional theory calculations showing that the silver ions in Ag3pz3 form a reversible π complex with C3H6, endowing the membranes with superior C3H6 affinity. The resulting membranes exhibit superior stability, C3H6/C3H8 selectivity as high as ≈200 and excellent C3H6 permeability of 306 Barrer, surpassing the upper bound selectivity/permeability performance line of polymeric membranes. This work provides a conceptually new approach of using coordinatively unsaturated 0D complexes as fillers in mixed matrix membranes, which can accomplish olefin/alkane separation with high performance.
High Performance Graphene–C60–Bismuth Telluride–C60–Graphene Nanometer Thin Film Phototransistor with Adjustable Positive and Negative Responses
Authors: Pan Rui , Cai Yuanlingyun , Zhang Feifei , Wang Si , Chen Lianwei , Feng Xingdong , Ha Yingli , Zhang Renyan , Pu Mingbo , Li Xiong , Ma Xiaoliang , Luo Xiangang 
Published: February 2023

AbstractGraphene is a promising candidate for the next‐generation infrared array image sensors at room temperature due to its high mobility, tunable energy band, wide band absorption, and compatibility with complementary metal oxide semiconductor process. However, it is difficult to simultaneously obtain ultrafast response time and ultrahigh responsivity, which limits the further improvement of graphene photoconductive devices. Here, a novel graphene/C60/bismuth telluride/C60/graphene vertical heterojunction phototransistor is proposed. The response spectral range covers 400–1800 nm; the responsivity peak is 106 A W−1; and the peak detection rate and peak response speed reach 1014 Jones and 250 µs, respectively. In addition, the regulation of positive and negative photocurrents at a gate voltage is characterized and the ionization process in impurities of the designed phototransistor at a low temperature is analyzed. Tunable bidirectional response provides a new degree of freedom for phototransistors' signal resolution. The analysis of the dynamic change process of impurity energy level is conducted to improve the device's performance. From the perspective of manufacturing process, the ultrathin phototransistor (20–30 nm) is compatible with functional metasurface to realize wavelength or polarization selection, making it possible to achieve large‐scale production of integrated spectrometer or polarization imaging sensor by nanoimprinting process.
Ambipolarity Regulation of Deep‐UV Photocurrent by Controlling Crystalline Phases in Ga2O3 Nanostructure for Switchable Logic Applications
Authors: Cheng Yuexing , Ye Junhao , Lai Li , Fang Shi , Guo Daoyou 
Published: February 2023

AbstractPhotoelectrochemical photocurrent switching (PEPS) effect can regulate the polarity of photocurrent, which has significant potential applications in areas such as logic gates, photosynapse, and artificial intelligence. In this work, it is reported for the first time that a pure Ga2O3 photoelectrochemical system exhibits ambipolar photocurrent behavior induced by deep ultraviolet, which is closely linked to the crystalline phase of Ga2O3 (α or β) and the surface states of oxygen vacancies. Spongy porous nanorod arrays (NRAs) of Ga2O3 designed here not only increase the contact area of Ga2O3 with the electrolyte but also can lower largely the reflection of light and improve light‐trapping capacity. For α phase Ga2O3, the photocurrent is in a forward direction under positive bias and shows a backward direction under negative bias in NaOH solution, exhibiting a distinct ambipolar photocurrent phenomenon, which can be attributed to more oxygen vacancy surface states and lower potential barrier at the semiconductor/electrolyte interface. Furtherly, the effect of the surface states on the ambipolar photocurrent behavior of α‐Ga2O3 NRAs is demonstrated by various treatment times of oxygen plasma, whose switching point moves from 0 V to −0.19 V with treatment for 30 min and continues to move in the negative direction with the increase of treatment time. Moreover, based on the ambipolar photocurrent behavior of α‐Ga2O3 NRAs, adjustable Boolean logic gates with voltage are prepared as the input source, offering a new path for the photoelectric device multifunctional integration needed in the Post‐Moore era, with a high accuracy manipulated by solar‐blind deep ultraviolet light.
Device‐to‐Materials Pathway for Electron Traps Detection in Amorphous GeSe‐Based Selectors
Authors: Slassi Amine , Medondjio Linda‐Sheila , Padovani Andrea , Tavanti Francesco , He Xu , Clima Sergiu , Garbin Daniele , Kaczer Ben , Larcher Luca , Ordejón Pablo , Calzolari Arrigo 
Published: February 2023

AbstractThe choice of the ideal material employed in selector devices is a tough task both from the theoretical and experimental side, especially due to the lack of a synergistic approach between techniques able to correlate specific material properties with device characteristics. Using a material‐to‐device multiscale technique, a reliable protocol for an efficient characterization of the active traps in amorphous GeSe chalcogenide is proposed. The resulting trap maps trace back the specific features of materials responsible for the measured findings, and connect them to an atomistic description of the sample. The metrological approach can be straightforwardly extended to other materials and devices, which is very beneficial for an efficient material‐device codesign and the optimization of novel technologies.
Reeling in complement in transplant‐associated thrombotic microangiopathy: You're going to need a bigger boat
Authors: Jodele Sonata , Sabulski Anthony 
Published: February 2023

AbstractOver the last decade there have been numerous advances in both the diagnosis and treatment of transplant‐associated thrombotic microangiopathy (TA‐TMA). These are largely the result of an improved understanding of complement activation in TA‐TMA and the ability to prevent end organ injury and death with timely initiation of complement‐blocking therapies. In this article, we review our current understanding of the pathophysiology of TA‐TMA, particularly as it pertains to complement activation, endothelial injury, and clinical management. We then review novel complement‐blocking therapies that are currently under investigation for use in TA‐TMA, as well as discuss special considerations for complement‐blocking therapy in hematopoietic stem cell transplant recipients. Through these reviews we aim to answer or at least provide an educated discussion on the most commonly posed TA‐TMA management questions and dilemmas.
Thriving from Work Questionnaire: Dimensionality, reliability, and validity of the long and short form questionnaires
Authors: Peters Susan E. , Gundersen Daniel A. , Katz Jeffrey N. , Sorensen Glorian , Wagner Gregory R. 
Published: February 2023

AbstractIntroductionThriving from Work is defined as the state of positive mental, physical, and social functioning in which workers' experiences of their work and working conditions enable them to thrive in their overall lives, contributing to their ability to achieve their full potential at work, at home, and in the community. The purpose of this study was to develop a psychometrically‐sound questionnaire measuring the positive contribution that work can have on one's well‐being both at, and outside of, their work.MethodsWe used both a qualitative and quantitative approach of item reduction, domain mapping dimensionality testing, development of “long‐” and “short‐” versions of the questionnaire, reliability, and construct and criterion validity testing. This was established in two independent online samples of US based workers (n = 1550, n = 500).ResultsWe developed a bi‐factor model 30‐item long‐form and a uni‐factorial 8‐item short‐version. The long‐form measures both the latent construct of Thriving from Work and six domains (psychological/emotional; work‐life integration; social; experience of work; basic needs; health). Both long‐ and short‐ forms were found to have high empirical reliability (0.93 and 0.87 respectively). The short‐form captures 94% of variance of the long‐form. Construct and criterion validity were supported. Test‐retest reliability was high.ConclusionsThe Thriving from Work Questionnaire appears to be a valid and reliable measure of work‐related well‐being in United States workers. Further testing is needed to refine and test the instrument in specific industries, unique worker populations, and across geographic regions.
Anatomical MRI staging of frontotemporal dementia variants
Authors: Planche Vincent , Mansencal Boris , Manjon José V. , Tourdias Thomas , Catheline Gwenaëlle , Coupé Pierrick ,   For the Frontotemporal Lobar Degeneration Neuroimaging Initiative and the National Alzheimer's Coordinating Center cohort
Published: February 2023

AbstractINTRODUCTIONThe three clinical variants of frontotemporal dementia (behavioral variant [bvFTD], semantic dementia, and progressive non‐fluent aphasia [PNFA]) are likely to develop over decades, from the preclinical stage to death.METHODSTo describe the long‐term chronological anatomical progression of FTD variants, we built lifespan brain charts of normal aging and FTD variants by combining 8022 quality‐controlled MRIs from multiple large‐scale data‐bases, including 107 bvFTD, 44 semantic dementia, and 38 PNFA.RESULTSWe report in this manuscript the anatomical MRI staging schemes of the three FTD variants by describing the sequential divergence of volumetric trajectories between normal aging and FTD variants. Subcortical atrophy precedes focal cortical atrophy in specific behavioral and/or language networks, with a “radiological” prodromal phase lasting 8–10 years (time elapsed between the first structural alteration and canonical cortical atrophy).DISCUSSIONAmygdalar and striatal atrophy can be candidate biomarkers for future preclinical/prodromal FTD variants definitions.Highlights
We describe the chronological MRI staging of the most affected structures in the three frontotemporal dementia (FTD) syndromic variants.

In behavioral variant of FTD (bvFTD): bilateral amygdalar, striatal, and insular atrophy precedes fronto‐temporal atrophy.

In semantic dementia: bilateral amygdalar atrophy precedes left temporal and hippocampal atrophy.

In progressive non‐fluent aphasia (PNFA): left striatal, insular, and thalamic atrophy precedes opercular atrophy.
Determinants of Infarct Core Growth During Inter‐hospital Transfer for Thrombectomy
Authors: Seners Pierre , Scheldeman Lauranne , Christensen Soren , Mlynash Michael , Ter Schiphorst Adrien , Arquizan Caroline , Costalat Vincent , Henon Hilde , Bretzner Martin , Heit Jeremy J. , Olivot Jean‐Marc , Lansberg Maarten G. , Albers Gregory W. ,   the Infarct‐Growth Collaborators
Published: February 2023

ObjectivePatients with acute ischemic stroke harboring a large vessel occlusion who present to primary stroke centers often require inter‐hospital transfer for thrombectomy. We aimed to determine clinical and imaging factors independently associated with fast infarct growth (IG) during inter‐hospital transfer.MethodsWe retrospectively analyzed data from acute stroke patients with a large vessel occlusion transferred for thrombectomy from a primary stroke center to one of three French comprehensive stroke centers, with an MRI obtained at both the primary and comprehensive center before thrombectomy. Inter‐hospital IG rate was defined as the difference in infarct volumes on diffusion‐weighted imaging between the primary and comprehensive center, divided by the delay between the two MRI scans. The primary outcome was identification of fast progressors, defined as IG rate ≥5 mL/hour. The hypoperfusion intensity ratio (HIR), a surrogate marker of collateral blood flow, was automatically measured on perfusion imaging.ResultsA total of 233 patients were included, of whom 27% patients were fast progressors. The percentage of fast progressors was 3% among patients with HIR < 0.40 and 71% among those with HIR ≥ 0.40. In multivariable analysis, fast progression was independently associated with HIR, intracranial carotid artery occlusion, and exclusively deep infarct location at the primary center (C‐statistic = 0.95; 95% confidence interval [CI], 0.93–0.98). IG rate was independently associated with good functional outcome (adjusted OR = 0.91; 95% CI, 0.83–0.99; P = 0.037).InterpretationOur findings show that a HIR > 0.40 is a powerful indicator of fast inter‐hospital IG. These results have implication for neuroprotection trial design, as well as informing triage decisions at primary stroke centers. ANN NEUROL 2023;93:1117–1129
C−N Coupling through Hydroaminoalkylation on a Single‐Atom Rh Heterogeneous Catalyst
Authors: Li Yuting , Tang Yu , Tao Franklin (Feng) 
Published: February 2023

AbstractC−N coupling is significant for the synthesis of fine chemicals toward various applications. Hydroaminoalkylation of olefins is a tandem reaction of C−N coupling involving first the formation of an aldehyde through hydroformylation of an olefin and then the production of amine through reductive amination of the aldehyde. Here we report a stable, supported catalyst of singly dispersed Rh1 atoms anchored on TiO2 (P25) nanoparticles designated as Rh1/P25. Its high activity for C−N coupling was demonstrated by six hydroaminoalkylations of olefins and amines with selectivity of higher than 90% for producing tertiary amines. The singly dispersed Rh1O4 on P25 exhibit activity and selectivity for hydroaminoalkylation comparable or even higher than some reported molecular catalysts. In contrast to molecular catalysts, the Rh‐based single‐atom Rh heterogeneous catalysis (Rh1/P25) can be readily separated from reactants and products, reused for multiple runs of hydroaminoalkylation, and recycled with a low cost.
Designing Heteroatom‐Codoped Iron Metal–Organic Framework for Promotional Photoreduction of Carbon Dioxide to Ethylene
Authors: Guo Fan , Li Rui‐Xia , Yang Sizhuo , Zhang Xiao‐Yu , Yu Hongjian , Urban Jeffrey J. , Sun Wei‐Yin 
Published: February 2023

AbstractRational engineering active sites and vantage defects of catalysts are promising but grand challenging task to enhance photoreduction CO2 to high value‐added C2 products. In this study, we designed an N,S‐codoped Fe‐based MIL‐88B catalyst with well‐defined bipyramidal hexagonal prism morphology via a facile and effective process, which was synthesized by addition of appropriate 1,2‐benzisothiazolin‐3‐one (BIT) and acetic acid to the reaction solution. Under simulated solar irradiation, the designed catalyst exhibits high C2H4 evolution yield of 17.7 μmol g−1⋅h, which has been rarely achieved in photocatalytic CO2 reduction process. The synergistic effect of Fe‐N coordinated sites and reasonable defects in the N,S‐codoped photocatalyst can accelerate the migration of photogenerated carriers, resulting in high electron density, and this in turn helps to facilitate the formation and dimerization of C−C coupling intermediates for C2H4 effectively.
A Pair of Interconverting Cages Formed from Achiral Precursors Spontaneously Resolve into Homochiral Conformers
Authors: Zuo Yong , Liu Xiaoning , Fu Enguang , Zhang Shaodong 
Published: February 2023

AbstractWithout chiral induction the emergence of homochirality from achiral molecules is rather serendipitous, as the rationale is somewhat ambiguous. We herein provide a plausible solution. From achiral precursors are formed a pair of interconverting cage conformers that exhibit a C3‐axis as the only symmetry element. When their interconversion is impeded with intramolecular H‐bonding, each conformer self‐sorts into a homochiral crystal, which is driven by a helical network of multivalent intermolecular interactions during the self‐assembly of homochiral cage conformers. As no chiral induction is involved throughout, we believe our study could enlighten the rational design for the emergence of homochirality with several criteria: 1) formation of a molecule without inversion center or mirror plane; 2) suppression of the enantiomeric interconversion, and introduction of multivalent interactions along the helical trajectory of screw symmetry within the resulting superstructure.