bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of neuroimaging scoring and clinical status in Korean patients with metachromatic leukodystrophy
Authors: Lee Sunho , Na Ji Hoon , Yoon Choon-Sik , Lee Young-Mock 
Published: March 2023

Abstract
Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by deficiency of arylsulfatase A, leading to progressive demyelination in the central and peripheral nervous systems and, causing gross motor deterioration. This study aimed to analyze data related to neuroimaging and clinical phenotypes of MLD patients according to disease subtype. Patients diagnosed with MLD based on arylsulfatase A enzymatic activity, demyelination in brain MR findings, and/or pathogenic mutations were enrolled in this study. The medical charts of patients with confirmed MLD were retrospectively reviewed. We used a modified MRI scoring system and clinical status using the analogous designed scale. We analyzed the correlation between MRI score and clinical status in the two groups divided by late-infantile and juvenile type, and specific neuroimaging lesions. We detected a positive relationship between clinical function deterioration and MRI score (rho 0.59, p 0.002) in patients with MLD. A stronger positive relationship between clinical score and brain MRI scoring (rho 0.700, p 0.003) was found in the late-infantile type than in the juvenile type. A strong relationship was also seen in groups with high signal intensities in the pons and basal ganglia, and cerebellar atrophy, but not in patients with lesions in the midbrain. MLD with a high MRI score is associated with poor clinical function. Correlating modified MRI scores and clinical function scale may help predict the prognosis of patients with MLD for identifying treatment options and increasing patientsʼ quality of life.
Gis-based Surface Irrigation Potential Assessment: a Case Study in Muga Watershed East Gojam Zone, Amhara Region, Ethiopia
Authors: abeza zelalem 
Published: March 2023

Abstract
Assessing available water and land for surface irrigation is important for planning their use. The high dependency on rain-fed farming and erratic rainfall require alternative ways of improving agricultural production. The alternative to improve is through development of small scale irrigation schemes by assessing the available suitable land and water resources in sub-basin level. The objective of this study was assessing the land and water resources potential of Muga watershed in East Gojjam Zone for surface irrigation development using Geographic Information System. Identification of suitable land, estimation of available river flow, and determination of irrigation water requirement were the main steps that were followed. The land irrigation suitability factors considered were: slope, soil, land use/land cover, and river proximity. Estimation of river flow in the six manually added outlets was conducted by simulation after calibration and validation were carried out with the observed flow of gauged river using Soil and water assessment tool. The commonly cultivated crops in the area maize, onion and potato were selected, and the irrigation water requirements of these crops were determined using the CROPWAT8.0 model. Comparison between gross irrigation water requirements of the selected crops for the identified suitable land with simulated river flow at the area of the selected site was carried out. Overall, the weighted overlay analysis of these factors gave a suitable land among river sub-basin as G/muga 560ha, E/muga 3057ha, Bora 670ha, Gibstawit 404ha, and Genet 241ha. Mean monthly flow of 11.4m3/s were determined at the watershed. A total of 3443ha (5.1%) was found to be potentially suitable for the development of surface irrigation project from a total watershed area of 67535ha. In conclusion, the irrigation potential of the area could be increased either by harvesting rainwater or using groundwater.
Deictic gestures impairment in individuals with at risk mental states for psychosis.
Authors: Lopes-Rocha Ana , Ramos Willian de Paula , Argolo Felipe , Gondim João Medrado , Mota Natalia , Andrade Julio , Ferreira Andrea Fontes Jafet , de Medeiros Matheus Wanderley , Serpa Mauricio Henriques , Cecchi Guillermo , Ara Anderson , Gattaz Wagner , Corcoran Cheryl Mary , Loch Alexandre 
Published: March 2023

Abstract
Background: Nonverbal communication (NVC) is a complex behavior that involves different modalities that are impaired in schizophrenia spectrum, including gesticulation. However, there are few studies that evaluate it in individuals with at-risk mental states (ARMS) for psychosis, mostly in developed countries. Given our prior findings of reduced movement during speech seen in Brazilian individuals with ARMS, we now aim to determine if this can be accounted for by reduced gesticulation behavior.
Methods: 56 medication-naïve ARMS and 64 healthy controls were filmed during speech tasks. The frequency of specific coded gestures across four categories (and self-stimulatory behaviors) were compared between groups and tested for correlations with prodromal symptoms of the Structured Interview for Prodromal Syndromes (SIPS) and with the variables previously published.
Results: ARMS individuals showed a reduction in one gesture category.Gesture frequency was negatively correlated with prodromal symptoms and positively correlated with the variables of amount of movement previously analyzed.
Conclusion: The reduction in gesture performance observed agrees with literature findings in other cultural contexts in ARMS and schizophrenia subjects. The lack of differences for other categories might be related to differences within the ARMS group itself and the course of the disorder. These findings show the importance of analyzing NVC in ARMS and of considering different cultural and sociodemographic contexts in the search for markers of these states.
Association between hospital spending and in-hospital mortality of patients with sepsis based on a Japanese nationwide medical claims database study—the Japan Sepsis Alliance study group
Authors: Oami Takehiko , Abe Toshikazu , Nakada Taka‑aki , Imaeda Taro , Aizimu Tuerxun , Takahashi Nozomi , Yamao Yasuo , Nakagawa Satoshi , Ogura Hiroshi , Shime Nobuaki , Umemura Yutaka , Matsushima Asako , Fushimi Kiyohide 
Published: March 2023

Abstract
Background:
The effect of hospital spending on the mortality rate of patients with sepsis has not yet been fully elucidated. We hypothesized that hospitals that consume more medical resources would have lower mortality rates among patients with sepsis.
Methods:
This retrospective study used administrative data from 2010 to 2017. The enrolled hospitals were divided into quartiles based on average daily medical cost per sepsis case. The primary and secondary outcomes were the average in-hospital mortality rate of patients with sepsis and the effective cost per survivor among the enrolled hospitals, respectively. A multiple regression model was used to determine the significance of the differences among hospital categories to adjust for baseline imbalances. Fractional polynomials and restricted cubic splines were used to determine the significance of the association between hospital spending and in-hospital mortality. Subgroup and sensitivity analyses were performed for the primary outcome.
Results:
Among 997 hospitals enrolled in this study, the crude in-hospital mortality rates were 15.7% and 13.2% in the lowest and highest quartiles of hospital spending, respectively. After adjusting for confounding factors, the highest hospital spending group demonstrated a significantly lower in-hospital mortality rate than the lowest hospital spending group (coefficient = − 0.025, 95% confidence interval [CI] − 0.034 to − 0.015; p < 0.0001). Similarly, the highest hospital spending group was associated with a significantly higher effective cost per survivor than the lowest hospital spending group (coefficient = 77.7, 95% CI 73.1 to 82.3; p < 0.0001). Analyses using fractional polynomials and restricted cubic splines revealed an inverse correlation between hospital spending and in-hospital mortality. In subgroup analyses, hospitals with a small or medium number of beds demonstrated a consistent pattern with the primary test, whereas those with a large number of beds or academic affiliations displayed no association.
Conclusions:
Using a nationwide Japanese medical claims database, this study indicated that hospitals with greater expenditures were associated with a superior survival rate and a higher effective cost per survivor in patients with sepsis than those with lower expenditures. In contrast, no correlations between hospital spending and mortality were observed in hospitals with a large number of beds or academic affiliations.
The effects of Treprostinil in high-risk patients after total cavo-pulmonary connection procedure
Authors: Wang Xiaofeng , Wang Shilin , Lu Zhongyuan , Wang Wenlong , Wang Peng , Zhu Zhiyuan , Wang Xu 
Published: March 2023

Abstract
Background: We hypothesized that administration of Treprostinil after high-risk total cavo-pulmonary connection (TCPC) procedure may be benefit for hemodynamics and post-operative recovery.
Methods: From 2015 to 2022, among patients who underwent TCPC procedure and received Treprostinil therapy in our single center, high-risk patients (mean pulmonary arterial pressure= 15mmHg) were retrospectively analyzed. Patients were separated into satisfactory recovery group and delayed recovery group based on whether the post-operative length of stay was more than 30 days. The peri-operative date of the two groups were investigated to find possible indicators to improve the post-operative recovery as the primary outcome. The hemodynamics data after 24 hours maintaining dose of Treprostinil were investigated as the second outcome.
Results: Among 371 TCPC patients, 24 patients were included in our study. There were 9 patients in satisfactory recovery group and 15 patients in delayed recovery group. The statistical difference existed in the maintaining dose of Treprostinil (p=0.005), pleural effusion volume (p=0.001) and renal replacement therapy (p=0.022). Through multivariable analysis, only Treprostinil was of statistical difference (p=0.027). The ROC curve shown that maintaining dose>19.5 ng/kg/min was the cut off point, with the area under curve 0.852, sensitivity 0.89, specificity 0.8. During the observation of hemodynamic data, the mean pulmonary artery pressure decreased from 14±4 to 12±3 mmHg (p<0.001) with no severe complications.
Conclusion: In patients after TCPC procedure, the Treprostinil therapy can decrease mean pulmonary artery pressure without severe complication. A maintaining dose of Treprostinil >19.5 ng/kg/min is benefit to shorten the post-operative length of hospital stay.
Greenness Assessment UV-Stability Spectrophotometric Methods for Determination of Dalfampridine in the Presence of its Oxidative Derivative
Authors: Kelani Khadiga M. , Talaat Wael , Omran Gamal A. , Morshedy Samir , Nassar Ahmed Mohmed Wafaa 
Published: March 2023

Abstract
This study describes three spectrophotometric techniques that were developed and verified for the reliable identification of dalfampridine (DFP) in the presence of its oxidative derivative, namely (Derivative ratio 1DD, Ratio subtraction RD, and Bivariate BI); calibration graphs were established in the range of (1–14 ug/mL) with good correlation coefficients. The established techniques have been effectively used to analyze Dalfampridine (DFP) in its pharmaceutical dose form. The procedures were verified in accordance with ICH requirements, and accuracy, precision, and repeatability were determined to be satisfactory. The degradation pathway was confirmed using TLC, IR, 1H NMR and mass spectrometry. In addition to Analytical Greenness metrics (AGREE) method and Analytical Eco-Scale tools were applied for DFP with greenness assessment.
Survivorship Experiences of Chinese Hematopoietic Stem Cell Transplantation Survivors: A Qualitative Study
Authors: Ruan Jiayin , Qian Ying , Zhuang Yiyu 
Published: March 2023

Abstract

Background:The number of global hematopoietic stem cell transplantation (HSCT) survivors is increasing rapidly. Survivors encounter many challenges, but studies regarding survivorship experiences in China are scarce.Objective:This study aimed to explore the survivorship experiences of Chinese patients with hematological cancers after HSCT and to describe the impact of HSCT on survivors’ lives.Methods:Descriptive qualitative research was employed. Purposive sampling was used to recruit HSCT survivors who were treated in Zhejiang Province from June 2021 to June 2022. Audio-recorded semi-structured interviews were conducted, transcribed verbatim, and analyzed via conventional content analysis.Results:Fifteen HSCT survivors aged 18-59 years participated in this study. Four themes and 11 subthemes emerged: (1) transplant being harder than you thought (body function impaired, forced to modify diet, disturbed by survivorship uncertainty), (2) difficulty blending into circles (limited activity space, suffering from discrimination), (3) adjusting value judgment (health being a top priority, contributing to family as much as possible, feeling worthless), and (4) still being the lucky one (recovered better than others, genuine relationships acquired, self-improvement achieved).Conclusion:This study offers insight into subjective survivorship experiences of patients with hematological cancers post-HSCT within a Chinese sociocultural context. It also presents changed perceptions of HSCT, life alterations, adjusted value judgments, and positive self-evaluation since treatment.Implications for Practice:Nurses can provide person-centered survivorship care based on understanding the survivorship experiences and needs of Chinese HSCT survivors. Intervention programs and informational materials should be developed to address difficulties encountered by Chinese HSCT survivors.
Magnetic field mediated charge density wave transport in Ni doped NbSe3 nanowires
Authors: Tang Hao , Li Yong , Yin Junyao , Xu Dongyan 
Published: March 2023

Abstract
Controllable manipulation of the transition between many-body ground states or metastable states in charge density wave (CDW) systems by external stimuli such as an electric field or optical pulse is of great interest to distinguish delicate interplay of quantum states and to design functional devices. Here, we report magnetization-induced transport anomalies in magnetic impurity Ni doped NbSe3 nanowires, which is toward suppressing the anomalous features of pristine CDW states and inducing the typical transport characteristics of disordered metallic phase accompanied by new emergent metastable CDW states or a tunneling-like transport behavior. These transport switching phenomena are ascribed to out-of-equilibrium disorder introduced by the reorientation of local charge/spin-density-wave domains, which partly retain even after switching off the magnetic field. Our observation will promote the understanding of the interaction between the CDW and the magnetic field coupled by magnetic impurities and pave a way to tune the CDW transport by magnetization, which may contribute to the development of CDW-based devices.
Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery​ and treatment of cancer
Authors: Gundersen Rebekah Anamarie , Chu Tianyuan , Abolfathi Kiana , Dogan Serap Gokcen Dogan Gokcen , Blair Phoebe Elizabeth , Nago Nyasha , Hamblin Michael , Brooke Greg Nicholas , Zwacka Ralf Michael , Hoshiar Ali Kafash , Mohr Andrea 
Published: March 2023

Abstract
Background: Combining the power of magnetic guidance and the biological activities of stem cells transformed into biohybrid microrobots holds great promise for the treatment of several diseases including cancer.
Results: We found that human MSCs can be readily loaded with magnetic particles and that the resulting biohybrid microrobots could be guided by a rotating magnetic field. Rotating magnetic fields have the potential to be applied in the human setting and steer therapeutic stem cells to the desired sites of action in the body. We could demonstrate that the required loading of magnetic particles into stem cells is compatible with their biological activities. We examined this issue with a particular focus on the expression and functionality of therapeutic genes inside of human MSC-based biohybrid microrobots. The loading with magnetic particles did not cause a loss of viability or apoptosis in the human MSCs nor did it impact on the therapeutic gene expression from the cells. Furthermore, the therapeutic effect of the gene products was not affected, and the cells did also not lose their migration potential.
Conclusion: These results demonstrate that the fabrication of guidable MSC-based biohybrid microrobots is compatible with their biological and therapeutic functions. Thus, MSC-based biohybrid microrobots represent a novel way of delivering gene therapies to tumours as well as in the context of other diseases.
Ileus and Subileus in the young bovine animal
Authors: Dirksen G. , Doll K. 
Published: March 2023

Forms of ileus and subileus occurring in the calf are predominantly as in the adult bovine animal, but there are certain differences in the younger animal concerning aetiology and pathogenesis of digestive tract obstruction as well as incidence, clinical appearance, diagnosis and therapy. In addition, types of ileus not yet observed in the adult ruminant occur in the young animal.
The differences mentioned could be due to, firstly, the fact that the gastrointestinal tract of the young animal is in the process of development and differs, sometimes considerably, from that of the adult as regards anatomy, topography and function. In addition, the specific symptoms appear to be influenced by the comparatively lower sensitivity to pain of younger individuals. As yet, this branch of buiatrics has on the whole not been closely studied; however, some communications concerning certain ileus forms are available.
The following review is of necessity restricted to the depiction of some characteristic aspects, due to the multiplicity of possible tract obstructions and the space available.
Chronic Bronchopneumonia in Cattle
Authors: Vestweber G. E. , Guffy M. , Kelly B. , Leipold H. W. 
Published: March 2023

Twenty-five calves had the following clinical signs of chronic bronchopneumonia: depression, gaunt appearance, subnormal appetite, bilateral mucopurulent nasal discharge, increased respiratory and heart rate, inspiratory or expiratory dyspnoea, infrequent cough, and an average rectal temperature of 103.5 deg F. On auscultation normal vesicular or harsh vesicular sounds were heard most commonly in the dorsal tripartition, moist or dry rales in the middle tripartition, and dry rales in the ventral tripartition. Changes associated with chronic bronchopneumonia decreased arterial blood pH, PO2, HCO3, total CO2, and base excess. These values (except oxygen tension) were also low in venous blood. Contrast bronchograms revealed extensive consolidation and atelectasis of the apical lobes and cardiac and diaphragmatic lobes ventral to the trachea. Angiograms revealed decreased blood supply to areas of the lung affected with chronic bronchopneumonia. Gross pathological changes were atelectasis and consolidation of the anterior ventral aspect of the lungs and emphysema dorsally. Histological changes consisted of atelectasis, emphysema, fibrous thickening of alveolar septa, abscess formation, peribronchial lymphocytic hyperplasia, and obstructive bronchiolitis.
Metabolic profile of grazing dairy cattle
Authors: Merrall M. 
Published: March 2023

The metabolic profile as it stands at the moment is not a valid tool for the diagnosis of nutritional balance on its own. It is useful, however, as part of a wider investigation of dairy cattle nutrition. It is useful for research in the possible selection of genetically superior animals and for investigations on different types of management systems. it is valuable as an aid in the diagnosis of clinical problems which have not been solved by conventional methods.
Role of DHI records in herd health programs
Authors: Stout Jack D. 
Published: March 2023

Herd owners that insist on having herd health programs without including DHI reocrds as the criteria for measureing results are penalizing the veterinarian and themselves. Herd health programs should be profitable to both dairymen and veterinarian. Many studies list veterinary and drug costs at $15 to $20 per cow per year. A 100-cow herd on this basis would be a good addition to any verinarian's practice. Likewise, if the dairyman reaps his proportionate increased returns, he should welcome the expenditure. However, neither individual should plan programs without a means of measureing the results. DHI records will furnish the answers you need for both parties.
Clinical classification of pneumonias in cattle
Authors: Pierson R. E. , Kainer Robert A. 
Published: March 2023

More beef cattle develop and subsequently die from respiratory diseases than from all other causes. In cattle under close confinement respiratory diseases cause 75% of the illnesses and 64% of the deaths. Pneumonias constitute 75% of the diagnoses of respiratory diseases.
Epizootics of respiratory disease are recognized by cattle owners who request and expect accurate diagnosis, but veterinarians experience difficulties making definitive diagnoses because of the similarity of signs in sick cattle and the many viral and bacterial pathogens recovered at necropsy.
Since a specific clinical diagnosis may be difficult to make in the field, the purpose of this paper is to simplify diagnoses by recommending a classification of pneumonias based on pathogenesis where major signs in each pneumonia are different and distinguishable.
To clarify this classification, each pneumonia will be discussed in relationship to etiology, pathogenesis, pathology, and clinical signs.
Management and husbandry aspects of foot lameness in dairy cattle
Authors: Pinsent P. J. N. 
Published: March 2023

There have always been cases of foot lameness in dairy cows. Even in prewar years there were lame cows, but the majority of these suffered from foul-in-the-foot (infectious pododermatitis), and from the complications of its neglect, whilst other developed pus-in-the-foot due to picked up nails and other penetrating foreign bodies. The incidence was relatively low, and the position of minor economic importance only.
In the post war years of intensive development in dairy managment, however, and particularly since the introduction of loose winter housing, the picture has changed and foot lameness has assumed alarming proportions, becoming a major economic problem in many dairy herds. It is estimated that 10% of all dairy cows in intensive management become lame each year, and that one half of these, i.e. 5%, are lame as a result of laminitis. A rough estimate suggests that lameness costs the dairy industry some £15,000,000 annually, but the true cost may be considerably higher, for many lame cows are recorded as culled due to the resultant poor milk yield, weight loss, or infertility, rather than to the primary lameness itself.
Until comparatively recently very few farmers or veterinary surgeons were genuinely interested in foot lameness, which, by and large, was regarded as an inescapable fact of life, however, the position is now far too serious to allow for futher complacency, and considerable efforts are being made to come to grips with this alarming problem, and to work out satisfactory preventive measures based on a study of the causative factors.