bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate change and the challenge to liberalism
Authors: Kang Susan , Havercroft Jonathan , Eisler Jacob , Wiener Antje , Shaw Jo 
Published: March 2023

AbstractIn this editorial, we consider the ways in which liberal constitutionalism is challenged by and presents challenges to the climate crisis facing the world. Over recent decades, efforts to mitigate the climate crisis have generated a new set of norms for states and non-state actors, including regulatory norms (emission standards, carbon regulations), organising principles (common but differentiated responsibility) and fundamental norms (climate justice, intergenerational rights, human rights). However, like all norms, these remain contested. Particularly in light of their global reach, their specific behavioural implications and interpretations and the related obligations to act remain debatable and the overwhelming institutionalization of the neoliberal market economy makes clear and effective responses to climate change virtually impossible within liberal societies.
Multiplexed DNA-functionalized graphene sensor with artificial intelligence-based discrimination performance for analyzing chemical vapor compositions
Authors: Hwang Yun Ji , Yu Heejin , Lee Gilho , Shackery Iman , Seong Jin , Jung Youngmo , Sung Seung-Hyun , Choi Jongeun , Jun Seong Chan 
Published: March 2023

AbstractThis study presents a new technology that can detect and discriminate individual chemical vapors to determine the chemical vapor composition of mixed chemical composition in situ based on a multiplexed DNA-functionalized graphene (MDFG) nanoelectrode without the need to condense the original vapor or target dilution. To the best of our knowledge, our artificial intelligence (AI)-operated arrayed electrodes were capable of identifying the compositions of mixed chemical gases with a mixed ratio in the early stage. This innovative technology comprised an optimized combination of nanodeposited arrayed electrodes and artificial intelligence techniques with advanced sensing capabilities that could operate within biological limits, resulting in the verification of mixed vapor chemical components. Highly selective sensors that are tolerant to high humidity levels provide a target for “breath chemovapor fingerprinting” for the early diagnosis of diseases. The feature selection analysis achieved recognition rates of 99% and above under low-humidity conditions and 98% and above under humid conditions for mixed chemical compositions. The 1D convolutional neural network analysis performed better, discriminating the compositional state of chemical vapor under low- and high-humidity conditions almost perfectly. This study provides a basis for the use of a multiplexed DNA-functionalized graphene gas sensor array and artificial intelligence-based discrimination of chemical vapor compositions in breath analysis applications.
Zinc hybrid sintering for printed transient sensors and wireless electronics
Authors: Fumeaux N. , Briand D. 
Published: March 2023

AbstractTransient electronics offer a promising solution for reducing electronic waste and for use in implantable bioelectronics, yet their fabrication remains challenging. We report on a scalable method that synergistically combines chemical and photonic mechanisms to sinter printed Zn microparticles. Following reduction of the oxide layer using an acidic solution, zinc particles are agglomerated into a continuous layer using a flash lamp annealing treatment. The resulting sintered Zn patterns exhibit electrical conductivity values as high as 5.62 × 106 S m−1. The electrical conductivity and durability of the printed zinc traces enable the fabrication of biodegradable sensors and LC circuits: temperature, strain, and chipless wireless force sensors, and radio-frequency inductive coils for remote powering. The process allows for reduced photonic energy to be delivered to the substrate and is compatible with temperature-sensitive polymeric and cellulosic substrates, enabling new avenues for the additive manufacturing of biodegradable electronics and transient implants.
Probing the link between cortical inhibitory and excitatory processes and muscle fascicle dynamics
Authors: Lauber Benedikt , Taube Wolfgang 
Published: March 2023

AbstractDuring movements, neural signals are translated into muscle fibre shortening, lengthening or they remain isometric. This study investigated cortical excitatory and inhibitory processes in relation to muscle fascicle dynamics during fixed-end rapid contractions. Fourteen adults performed submaximal and maximal ankle dorsiflexions. Single and paired pulse transcranial magnetic stimulation over the cortical representation projecting to the tibialis anterior (TA) was applied during rest, the activation and deactivation phase of contractions to test for short- (SICI) and long-interval intracortical inhibition (LICI) and intracortical facilitation (ICF). Ultrasound images were taken to measure muscle fascicle dynamics of the superficial (TASF) and deep (TADP) TA compartments. The results show significantly greater maximal shortening velocities (p = 0.003, d = 0.26, CI [4.89, 18.52]) and greater maximal fascicle shortening (p = 0.003, d = 0.86, CI [0.29, 3.13]) in TASF than TADP during submaximal dorsiflexions. Significantly lower SICI levels during activation compared to deactivation (p = 0.019, d = 1.12, CI [19.82, 1.76]) and at rest (p < 0.0001) were observed. ICF was significantly greater during activation (p = 0.03) than during rest while LICI did not modulate significantly. Maximal TASF but not TADP shortening velocity correlated with SICI levels at activation (p = 0.06) and with the rate of torque development (p = 0.02). The results suggest that SICI might be related to muscle fascicle behavior and that intracortical inhibition and excitation are phase-dependently modulated.
Spectrotemporal content of human auditory working memory represented in functional connectivity patterns
Authors: Ahveninen Jyrki , Uluç Işıl , Raij Tommi , Nummenmaa Aapo , Mamashli Fahimeh 
Published: March 2023

AbstractRecent research suggests that working memory (WM), the mental sketchpad underlying thinking and communication, is maintained by multiple regions throughout the brain. Whether parts of a stable WM representation could be distributed across these brain regions is, however, an open question. We addressed this question by examining the content-specificity of connectivity-pattern matrices between subparts of cortical regions-of-interest (ROI). These connectivity patterns were calculated from functional MRI obtained during a ripple-sound auditory WM task. Statistical significance was assessed by comparing the decoding results to a null distribution derived from a permutation test considering all comparable two- to four-ROI connectivity patterns. Maintained WM items could be decoded from connectivity patterns across ROIs in frontal, parietal, and superior temporal cortices. All functional connectivity patterns that were specific to maintained sound content extended from early auditory to frontoparietal cortices. Our results demonstrate that WM maintenance is supported by content-specific patterns of functional connectivity across different levels of cortical hierarchy.
Prevalence of Self-Reported Bothersome Tinnitus in U.S. Army Soldiers From January 1, 2015, Through September 30, 2019
Authors: Sherlock LaGuinn P. , Gibson Kelly J. , Talian Daniel S. , Lake Deborah C. 
Published: March 2023

Purpose:
Tinnitus is a symptom of auditory dysfunction or injury and can be a precursor to permanent hearing loss. Tinnitus can interfere with communication, sleep, concentration, and mood; when this occurs, it is referred to as bothersome tinnitus. Annual hearing surveillance in the U.S. Army includes screening for bothersome tinnitus. Estimating the prevalence of self-reported bothersome tinnitus can facilitate prioritization of prevention and education efforts. The objective of this study was to examine Army hearing conservation data to estimate the prevalence of self-reported bothersome tinnitus as a function of age, hearing, sex, service component, and pay grade.

Method:
The study employed a cross-sectional, retrospective design. Records from 1,485,059 U.S. Army Soldiers retrieved from the Defense Occupational and Environmental Health Readiness System–Hearing Conservation were analyzed. Descriptive statistics and multinomial logistic regression analysis were used to estimate the prevalence of bothersome tinnitus and its associations with Soldiers' demographic characteristics.

Results:
The estimated prevalence of self-reported bothersome tinnitus was 17.1% between January 1, 2015, and September 30, 2019; 13.6% of the Soldiers reported “bothered a little” and 3.5% reported “bothered a lot.” Proportionally, the prevalence of self-reported bothersome tinnitus was higher for males, older Soldiers, and Reserve Component Soldiers. For every 1-year increase in age, the odds of self-reporting “bothered a little” tinnitus relative to “bothered not at all tinnitus” would be expected to increase by 2.2% (2.1%, 2.3%), and the odds of self-reporting “bothered a lot” tinnitus relative to “bothered not at all” tinnitus would be expected to increase by 3.6% (3.5%, 3.7%).

Conclusions:
The self-reported prevalence of bothersome tinnitus in the U.S. Army (17.1%) is substantially higher than that of the general population, where prevalence of bothersome tinnitus is estimated at 6.6%. Examination of bothersome tinnitus among Soldiers is an important step toward optimizing prevention, education, and intervention efforts.
Design and implementation of a novel zero‐current switching method for low‐power DC–DC converters
Authors: Hosseini Arya , Sheikhaei Samad , Davari Masoud 
Published: March 2023

AbstractThis paper introduces a unique zero‐current switching (ZCS) technique for low‐power dc–dc converters. In this paper, a single‐inductor dual‐input triple‐output converter is considered to apply this new technique, which can be generalized for converters with more inputs and outputs and high‐power and energy‐harvesting applications. The first input of this converter can be connected to any source that can produce energy, such as photovoltaic (PV) cells or thermoelectric generator (TEG), and the second input can be considered a battery. The proposed converter is implemented discretely, and a low‐power microcontroller whose power consumption is reduced by the software is employed to control the whole system. In the proposed ZCS method, the current sensor is not used, and only a simple voltage level detector is employed to detect the inductor voltage level in order to determine the optimal value of the inductor discharge duty cycle. This converter works in discontinuous conduction mode (DCM) and uses pulse width modulation (PWM) and the time‐multiplexing strategy (TMS). The main focus of this paper is on designing and implementing a digital control algorithm based on this new ZCS technique in order to increase efficiency.
Uncertainty-aware blob detection with an application to integrated-light stellar population recoveries
Authors: Parzer Fabian , Jethwa Prashin , Boecker Alina , Alfaro-Cuello Mayte , Scherzer Otmar , van de Ven Glenn 
Published: March 2023

Context. Blob detection is a common problem in astronomy. One example is in stellar population modelling, where the distribution of stellar ages and metallicities in a galaxy is inferred from observations. In this context, blobs may correspond to stars born in situ versus those accreted from satellites, and the task of blob detection is to disentangle these components. A difficulty arises when the distributions come with significant uncertainties, as is the case for stellar population recoveries inferred from modelling spectra of unresolved stellar systems. There is currently no satisfactory method for blob detection with uncertainties.Aims. We introduce a method for uncertainty-aware blob detection developed in the context of stellar population modelling of integrated-light spectra of stellar systems.Methods. We developed a theory and computational tools for an uncertainty-aware version of the classic Laplacian-of-Gaussians method for blob detection, which we call ULoG. This identifies significant blobs considering a variety of scales. As a prerequisite to apply ULoG to stellar population modelling, we introduced a method for efficient computation of uncertainties for spectral modelling. This method is based on the truncated Singular Value Decomposition and Markov chain Monte Carlo sampling (SVD-MCMC).Results. We applied the methods to data of the star cluster M 54. We show that the SVD-MCMC inferences match those from standard MCMC, but they are a factor 5–10 faster to compute. We apply ULoG to the inferred M 54 age/metallicity distributions, identifying between two or three significant, distinct populations amongst its stars.
Improved prior for adaptive optics point spread function estimation from science images: Application for deconvolution
Authors: Lau A. , Fétick R. J. L. , Neichel B. , Beltramo-Martin O. , Fusco T. 
Published: March 2023

Context. Access to knowledge of the point spread function (PSF) of adaptive optics(AO)-assisted observations is still a major limitation when processing AO data. This limitation is particularly important when image analysis requires the use of deconvolution methods. As the PSF is a complex and time-varying function, reference PSFs acquired on calibration stars before or after the scientific observation can be too different from the actual PSF of the observation to be used for deconvolution, and lead to artefacts in the final image.
Aims. We improved the existing PSF-estimation method based on the so-called marginal approach by enhancing the object prior in order to make it more robust and suitable for observations of resolved extended objects.
Methods. Our process is based on a two-step blind deconvolution approach from the literature. The first step consists of PSF estimation from the science image. For this, we made use of an analytical PSF model, whose parameters are estimated based on a marginal algorithm. This PSF was then used for deconvolution. In this study, we first investigated the requirements in terms of PSF parameter knowledge to obtain an accurate and yet resilient deconvolution process using simulations. We show that current marginal algorithms do not provide the required level of accuracy, especially in the presence of small objects. Therefore, we modified the marginal algorithm by providing a new model for object description, leading to an improved estimation of the required PSF parameters.
Results. Our method fulfills the deconvolution requirement with realistic system configurations and different classes of Solar System objects in simulations. Finally, we validate our method by performing blind deconvolution with SPHERE/ZIMPOL observations of the Kleopatra asteroid.
Slow solar wind sources
Authors: Barczynski Krzysztof , Harra Louise , Schwanitz Conrad , Janitzek Nils , Berghmans David , Auchère Frédéric , Aznar Cuadrado Regina , Buchlin Éric , Kraaikamp Emil , Long David M. , Mandal Sudip , Parenti Susanna , Peter Hardi , Rodriguez Luciano , Schühle Udo , Smith Phil , Teriaca Luca , Verbeeck Cis , Zhukov Andrei N. 
Published: March 2023

Context. The origin of the slow solar wind is still an open issue. One possibility that has been suggested is that upflows at the edge of an active region can contribute to the slow solar wind.
Aims. We aim to explain how the plasma upflows are generated, which mechanisms are responsible for them, and what the upflow region topology looks like.
Methods. We investigated an upflow region using imaging data with the unprecedented temporal (3 s) and spatial (2 pixels = 236 km) resolution that were obtained on 30 March 2022 with the 174 Å channel of the Extreme-Ultraviolet Imager (EUI)/High Resolution Imager (HRI) on board Solar Orbiter. During this time, the EUI and Earth-orbiting satellites (Solar Dynamics Observatory, Hinode, and the Interface Region Imaging Spectrograph, IRIS) were located in quadrature (∼92°), which provides a stereoscopic view with high resolution. We used the Hinode/EIS (Fe XII) spectroscopic data to find coronal upflow regions in the active region. The IRIS slit-jaw imager provides a high-resolution view of the transition region and chromosphere.
Results. For the first time, we have data that provide a quadrature view of a coronal upflow region with high spatial resolution. We found extended loops rooted in a coronal upflow region. Plasma upflows at the footpoints of extended loops determined spectroscopically through the Doppler shift are similar to the apparent upward motions seen through imaging in quadrature. The dynamics of small-scale structures in the upflow region can be used to identify two mechanisms of the plasma upflow: Mechanism I is reconnection of the hot coronal loops with open magnetic field lines in the solar corona, and mechanism II is reconnection of the small chromospheric loops with open magnetic field lines in the chromosphere or transition region. We identified the locations in which mechanisms I and II work.
A Significant Role of Nontypeable Haemophilus influenzae in Acute Otitis Media in Bulgarian Children
Authors: Alexandrova Alexandra Sashova , Hristova Preslava , Hitkova Hristina , Gergova Raina Tsvetanova 
Published: March 2023

Abstract
Objective We conducted a study on Haemophilus influenzae isolates recovered from children with acute otitis media (AOM). We aimed to establish the distribution of noncapsulated (also known as nontypeable Haemophilus influenzae [NTHi]) and encapsulated H. influenzae in the study population, and the antimicrobial susceptibilities of the isolates.
Methods We collected 113 nasopharyngeal swabs and 91 middle ear fluids/otorrhea specimens from patients up to 9 years of age with AOM. Of these, 26.1% (n = 53) were culture-positive for H. influenzae. Only one episode of AOM was included per patient. Conventional tests and rapid panel Neisseria/Haemophilus panel were used for the identification of the isolates. Detection of encapsulated and noncapsulated strains was done by polymerase chain reaction (PCR) for bexA gene. PCR-serotyping was performed for capsule types: “a” and “f.” Biotypes were assigned based on the indole, urease, and ornithine decarboxylase activity. Susceptibility testing was performed according to the criteria of European Committee on Antimicrobial Susceptibility Testing (EUCAST).
Results Capsule determination showed that 96.2% of H. influenzae isolates responsible for “mild” and “severe” AOM cases in children were NTHi. Biotype I was predominantly associated with AOM isolates. Capsule types “a” and “c” were found in two isolates. Antibiotic resistance was found in 39.6% of the isolates. The highest resistance rate was for trimethoprim-sulfamethoxazole (37.7%). About 20.7% of isolates were ampicillin-resistant: 5.6% expressed a β-lactamase, and 15.1% had a β–lactamase-negative ampicillin-resistant phenotype.
Conclusion The current prevalence rates of nonsusceptible H. influenzae to ampicillin appear to be low among AOM. NTHi is an emergent pathogen in AOM cases. Ongoing observations are needed about how NTHi colonizes, survives, and evolves into a leading causative agent of H. influenzae diseases.
The Post–Venous Thromboembolism Functional Status Scale: From Call to Action to Application in Research, Extension to COVID-19 Patients, and Its Use in Clinical Practice
Authors: de Jong Cindy M. M. , Boon Gudula J.A.M. , Le Y. N. Jenny , Barco Stefano , Siegerink Bob , Klok Frederikus A. 
Published: March 2023

AbstractA broad spectrum of long-term sequelae may be present in venous thromboembolism (VTE) survivors, affecting their quality of life and functioning. To monitor recovery and improve the prognosis of patients with persistent functional limitations, the development of a new outcome measure that could better capture the consequences of VTE was an unmet need. Starting as a call to action, the Post-VTE Functional Status (PVFS) scale was developed to meet this need. The PVFS scale is an easy-to-use clinical tool to measure and quantify functional outcomes after VTE by focusing on key aspects of daily life. As the scale was considered useful in coronavirus disease 2019 (COVID-19) patients as well, the Post-COVID-19 Functional Status (PCFS) scale was introduced early in the pandemic after slight adaptation. The scale has been well incorporated into both the VTE and COVID-19 research communities, contributing to the shift of focus toward patient-relevant functional outcomes. Psychometric properties have been evaluated, mainly for the PCFS scale but recently also for the PVFS scale, including validation studies of translations, showing adequate validity and reliability. In addition to serving as outcome measure in studies, guidelines and position papers recommend using the PVFS and PCFS scale in clinical practice. As broad use of the PVFS and PCFS scale in clinical practice is valuable to capture what matters most to patients, widespread implementation is a crucial next step. In this review, we discuss the development of the PVFS scale and introduction in VTE and COVID-19 care, the incorporation of the scale in research, and its application in clinical practice.
A Novel NR5A1 Mutation in a Thai Boy with 46, XY DSD
Authors: Wacharasindhu Suttipong , Ittiwut Chupong , Ittiwut Rungnapa , Aroonparkmongkol Suphab , Suphapeetiporn Kanya 
Published: March 2023

AbstractDisorders of sex development (DSD) can be classified as 46,XX DSD, 46,XY DSD, and sex chromosome DSD. Several underlying causes including associated genes have been reported. Steroidogenic factor-1 is encoded by the NR5A1 gene, a crucial regulator of steroidogenesis in the growth of the adrenal and gonadal tissues. It has been discovered to be responsible for 10 to 20% of 46, XY DSD cases. Here, we described a 2-month-old infant who had ambiguous genitalia and 46, XY. Using whole exome sequencing followed by polymerase chain reaction–Sanger sequencing, a novel heterozygous nonsense c.1249C > T (p.Gln417Ter) variant in the NR5A1 gene was identified. It is present in his mother but absent in his father and maternal aunt and uncle. At the age of 7 months, the patient received a monthly intramuscular injection of low-dose testosterone for 3 months in a row. His penile length and diameter increased from 1.8 to 3 cm and from 0.8 to 1.3 cm, respectively. The patient also had normal adrenal reserve function by adrenocorticotropic hormone stimulation test. This study identified a novel causative p.Q417X (c.1249C > T) variant in NR5A1 causing 46,XY DSD in a Thai boy which is inherited from his unaffected mother.