bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative evaluation of the accuracy and cost-effectiveness of rapid-prototyped orthodontic models 3D printed in vertical and horizontal orientations: An in-vitro study
Authors: SUBBAIAH NAVEEN K , CHAUDHARI PRABHAT KUMAR , DUGGAL RITU , SAMRIT VILAS D 
Published: March 2023

Abstract
Objectives: The purpose of this study was to evaluate the accuracy and cost-effectiveness of the rapid-prototyped dental models 3D printed in vertical and horizontal orientation as compared to the gold standard conventional plasterand digital models.
Methods: This in vitro study involved scanning of 50 plaster dental models (25 maxillary and 25 mandibular) using Maestro 3D Desktop Scanner (AGE Solutions, Pisa, Italy). The STL file obtained from the scanner was processed and three-dimensional (3D) printed in the horizontal and vertical orientation using a polyjet 3D printer (Objet 30 prime, Stratasys Ltd., Eden Prairie, Minnesota, United States). The accuracy of the rapid-prototyped (3D printed) models were measured from the pre-determined landmarks and were compared among the groups. In addition, the determination of the cost-effectiveness of the 3D printed models in different orientations was based on the amount of material (resin) utilized during the 3D printing process.
Results: There were statistically insignificant differences (P>0.05) among rapid-prototyped models, plaster models, and digital models for the linear measurements made in all three planes of space with excellent reliability (ICC > 0.804), and internal consistencies (Cronbach’s alpha > 0.910). The dental models printed in the horizontal orientation were found more cost-effective as compared to models printed in a vertical orientation in terms of the amount of material (resin) utilized and printing time during the 3D printing process.
Conclusion: There was no significant difference in terms of accuracy between the rapid-prototyped models 3D printed in the horizontal and vertical orientation. Horizontally printed models were more cost-effective than vertically printed models.
Machine Learning algorithms for in-line monitoring during Yeast Fermentations based on Raman Spectroscopy
Authors: Wu Debiao , Xu Yaying , Xu Feng , Shao Minghao , Huang Mingzhi 
Published: March 2023

Abstract
Given the nonlinear and complex industrial fermentation system, the process analytical technology offers significant advantages for direct and real-time monitoring, control and evaluation of synthetic processes. Here, we introduced a Raman spectroscopy in-line monitoring method for ethanol production by Saccharomyces cerevisiae. First, the feature selection methods in machine learning were used to reduce the dimension of Raman spectral data. The results showed that the model training time is reduced by more than 90% after feature selection, while the prediction performance of glycerol and cell concentration is improved by 14.20% and 17.10% at the RMSE level. Then, 15 machine learning algorithms were called to retrain the model, and hyperparameters were adjusted by grid search. The results demonstrated that the model after adjusting the hyperparameters improved the RMSE of ethanol, glycerol, glucose, and biomass by 9.73%, 4.33%, 22.22%, and 13.79%, respectively. Finally, BaggingRegressor, Support vector regression, BayesianRidge, and VotingRegressor are suitable machine learning algorithms corresponding to the models for predicting glucose, ethanol, glycerol, and cell concentrations, respectively. In addition, the R-squared values were 0.89–0.97, and the RMSE values were 0.06–2.59 g/L on the testing datasets, respectively. The results suggested that machine learning methods can be effectively applied in the modeling and analysis of Raman spectroscopy. Moreover, it is conducive to promoting the optimization of Raman spectroscopy in biological process monitoring, thereby improving industrial production efficiency, and providing novel modeling ideas.
The Automation Software of Tian-Ma Radio Telescope RFI Monitoring System
Authors: Zhang Dong , Zhao Rong-Bing , Li Bin , Shang-Guan Wei-Hua , Yan Zhen , Zhang Chu-Yuan 
Published: March 2023

Abstract
The Radio Frequency Interference (RFI) generated by the surrounding environment will significantly reduce the observation efficiency of the large radio telescope. The Tian-Ma Radio Telescope (TMRT) has established a RFI monitoring system to keep watch on its surrounding RFI environment chronically in the L, S, C and X bands. The system consists of antennas, receivers, back-ends and control system. To achieve automatic system operation, we design and implement an automation software based on Tango Controls open source framework. This paper will briefly introduce the TMRT RFI Monitoring System (TRMS), and describe the functional design, architecture design and implementation of the automation software. Finally, With the help of this system, we carry out automatic remote monitoring of the RFI environment around the TMRT in the 1.2 GHz-12GHz frequency band, and then analyze and verify the observation results.
Lithium-functionalized graphene oxide with a low load of Pt as an efficient counter electrode for dye-sensitized solar cells
Authors: Mohammadnejad S. , Mohammadi M. Reza , Ghartavol H. Mokarami 
Published: March 2023

Abstract
Low-cost materials with excellent chemical stability, high conductivity, and catalytic properties have attracted much attention as an alternative to conventional Pt counter electrodes in dye-sensitized solar cells (DSSCs). Herein, graphene oxide (GO) sheets were successfully synthesized via the improved Hummers’ method, functionalized with lithium and characterized by SEM, AFM, XRD, Raman, UV-Vis, and FTIR techniques. The impact of GO thickness, heat treatment temperature, and hybridization with Pt particles on photovoltaic performance of the counter electrodes (CEs) were studied. A solar efficiency of 2.47% and 2.94% was achieved for the pristine GO and Li-functionalized GO electrodes, respectively under an optimized condition. A hybrid structure of GO or Li-functionalized GO films coated with an ultra-thin Pt film (i.e., GO-Pt or LiGO-Pt CEs) led to a remarkable efficiency of 7.07% and 8.87%, respectively. Such superior photovoltaic performance of LiGO-Pt CE indicated an increase of 61% in cell efficiency compared to the conventional Pt counter electrodes. The design of GO-based counter electrodes decorated with Pt deposition and Li functionalization will open a new concept for improvement of power conversion efficiency of DSSCs.
The second fundamental form of the real Kaehler submanifolds
Authors: Chion Sergio , Dajczer Marcos 
Published: March 2023

Abstract
Let $f\colon M^{2n}\to\R^{2n+p}$, $2\leq p\leq n-1$, be an isometric immersion of a Kaehler manifold into Euclidean space. Yan and Zheng conjectured in \cite{YZ} that if the codimension is $p\leq 11$ then, along any connected component of an open dense subset of $M^{2n}$, the submanifold is as follows: it is either foliated by holomorphic submanifolds of dimension at least $2n-2p$ with tangent spaces inthe kernel of the second fundamental form whose images are open subsets of affine vector subspaces, or it is embedded holomorphically in a Kaehler submanifold of $\R^{2n+p}$ of larger dimension than $2n$. This bold conjecture was proved by Dajczer and Gromoll just for codimension three and then by Yan and Zheng for codimension four.
In this paper we prove that the second fundamental form of the submanifold behaves pointwise as expected in case that the conjecture is true. This result is a first fundamental step fora possible classification of the non-holomorphic Kaehler submanifolds lying with low codimension in Euclidean space. A counterexample shows that our proof does not work for higher codimension, indicating that proposing $p=11$ in the conjecture as the largest codimension is appropriate.
Effect of Hydrostatic Pressure on the Auger Current Density of InGaN/GaN Multiple Quantum Well Light-emitting Diodes
Authors: yahyazadeh Rajab 
Published: March 2023

Abstract
In this study, a numerical model was used to analyze the Auger current in c-plane InGaN/GaN multiple-quantum-well light-emitting diodes (MQWLED) under hydrostatic pressure. Finite difference techniques were employed to acquire energy eigenvalues and their corresponding eigenfunctions of \({\text{InGaN/GaN}}\) MQWLED, and the hole eigenstates were calculated via a 6×6 k.p method under applied hydrostatic pressure. Our calculations demonstrated that the hole-hole-electron (CHHS) and electron-electron-hole (CCCH) Auger coefficients had the largest contribution to the total Auger coefficient (76% and 20%, respectively). It was found that a change in pressure up to 10 GPa increases the carrier density up to 0.75×1019cm−3 and 0.56×1019cm−3 for the holes and electrons, respectively, and the effective band gap. Based on the result, it could decrease the exaction binding energy, rise the electric field rate up to 0.77MV/cm, and decrease the Auger coefficient and Auger current up to 2.1×10− 31 cm6s− 1and 75A/cm2 in the multiple-quantum well regions, respectively. Our studies provided more detailed insight into the origin of the Auger current drop under hydrostatic pressure in InGaN-based LEDs.
A pathogenic germline BRCA1 mutation in a patient with non-Hodgkin lymphoma and rectum adenocarcinoma
Authors: Zhou You , Xu Yanjie , Zhao Jiemin , Ni Xuefeng , Hu Wenwei 
Published: February 2023

Abstract
Tumor suppressor gene BRCA1, known for its vital roles in regulating DNA damage, is frequently mutated in hereditary breast and ovarian cancer (HBOC), whose mutation also increases susceptibility to intestinal, prostatic and pancreatic cancers of patients. As the main subtype of lymphoma, non-Hodgkin lymphoma (NHL) is malignant disorders arising from immune cells and displays predominantly as lymphadenopathy or solid tumors, which is rarely considered hereditary. However, the relationship between BRCA1 mutation and NHL is rarely reported. Here, we present a primary NHL and recent second primary tumor rectum adenocarcinoma. Considering the hereditary factors in developing colorectal cancer, we investigated her family history and found her sister died with ovarian cancer. Meanwhile, her genetic testing identified a pathologic germline mutation in BRCA1 (c.1115G＞A). Taken into account the strong evidence between BRCA1 mutation and HBOC occurrence, we also did genetic test for her daughter and found the same BRCA1 mutation. Although strong evidence between BRCA1 mutation and HBOC exists, the patient harboring pathogenic BRCA1 mutation did not suffer from HBOC but NHL and rectum adenocarcinoma which required further investigations and modifications of current screening criteria for HBOC. And great attention should also be paid to her daughter with BRCA1 mutation carrier.
Using vacuum-assisted ureteral access sheath in the treatment of complex steinstrasse: a multi- center study
Authors: Wang Dong , Xu Yuyu , Liu Zhen , Liang Jian , Lai Dehui , Guan Wenfeng , Xu Guibin 
Published: March 2023

Abstract
Introduction: Steinstrasse is an iatrogenic condition resulting from upper urinary tract lithotripsy. Uncomplicated steinstrasse can be managed expectantly. Complex steinstrasse can pose a therapeutic challenge. The vacuum-assisted ureteral access sheath (vaUAS) is similar to a conventional ureteral access sheath but has a side branch that can be connected to vacuum apparatus. This device seemed to be useful in the management of complex steinstrasse. Material and Method: 35 patients with complex steinstrasse, defined as steinstrasse containing ≥ 4 stones or with an aggregate length of ≥ 1.5 cm, were treated in four tertiary medical centers using the vaUAS in this prospective and non-randomized study. The vaUAS was inserted into the ureter over a guidewire until the tip of the vaUAS was in contact with the lowermost stone fragment. A 7 Fr./8.4 Fr. semirigid ureteroscope and a holmium laser were used to pulverize the obstructing stone. All the stone fragments were aspirated either in the space between the scope and the sheath, or through the channel of the sheath by withdrawing the scope to the proximal of the aspiration port. Result: All patients were steinstrasse-free at end of the procedure, as assessed visually and by KUB. At the three-month follow-up, 94.3% of patients were stone-free with or without a supplementary procedure. There were no perioperative complications. Five patients experienced postoperative fever and/or significant hematuria, and one patient had transient sepsis, a grade I and IV Clavien complication respectively. Conclusion: vaUAS can be an effective adjunctive device in the management of complex steinstrasse.
Stakeholder perspectives on the impact of Covid-19 on Oncology services: A qualitative study
Authors: Butow Phyllis , Havard Polly E. , Butt Zoe , Juraskova Ilona , Sharpe Louise , Dhillon Haryana , Beatty Lisa , Beale Philip , Cigolini Maria , Kelly Brian , Chan Raymond J. , Kirsten Laura , Best Megan C. , Shaw Joanne 
Published: March 2023

Abstract
Background: As COVID-19 spread across the globe, cancer services were required to rapidly pivot to minimise risks without compromising outcomes for patients or staff. The aim of this study was to document changes to Oncology services as a result of COVID-19 from the perspectives of both providers and receivers of care during the initial phase of the pandemic.
Methods: Participants were recruited between June and December 2020 through an email invitation via professional or consumer organisations, two hospital-based oncology services and snowballing. Semi-structured interviews focused on health service changes and their impacts, which were then analysed by thematic analysis.
Results: Thirty-two patients, 16 carers and 29 health professionals were recruited. Fifteen patients (n=47%) had localised disease and 19 (n=59%) were currently receiving treatment. Oncology staff included oncologists, palliative care physicians, nurses, allied health and psychosocial practitioners. Four themes arose from the data: safety, increased stress and burnout, communication challenges, and quality of cancer care.
Conclusions: There is an ongoing need for cancer-specific information from a single, trusted source to inform medical practitioners and patients/carers. More data are required to inform evidence-based guidelines for cancer care during future pandemics. All stakeholders require ongoing support to avoid stress and burnout.
Temporal patterns of nickel transfer from soil to rice in terraced paddy fields affected by serpentinite
Authors: Harada Nodoka , Nakao Atsushi , Matsuo Eika , Tomita Hodaka , Masumura Takehiro , Nishikiori Tatsuhiro , Yanai Junta 
Published: March 2023

Abstract
Nickel (Ni) is an essential micronutrient for plants although it is considered toxic when present in excess in the soil. This study investigated the transfer of Ni from the soil to rice in terraced paddy fields affected by serpentinite, which contains an anomalously higher Ni content compared with other geological materials. Soils, soil solutions, and rice plants were collected at several different growing stages from three adjacent terraced paddy fields subject to the same water and fertilizer management. Temporal changes in their elemental compositions revealed that a higher concentration of Ni was dissolved in the soil solution during flooded conditions, probably due to the co-solubilization with Mn oxides under low redox potential conditions. However, rice accumulated Ni at a higher rate during the drainage period than in the flooding period. Although the Ni concentration in the soil solution was lowest in the drainage period, the relative concentration to Fe (i.e., Ni/Fe ratio) was much higher than that in flooded conditions. These relationships suggest that a potential measure to counter the transfer of Ni from the soil to rice in serpentine-affected paddy fields is to increase Fe phytoavailability during the drainage period.
Impact of land tenure security through customary law on agricultural productivity in Burkina Faso: Propensity score matching approaches
Authors: NOUFE Tiatité 
Published: March 2023

Abstract
Land tenure security plays an important role in agricultural production systems. The objective of this paper is to empirically assess the impact of land tenure security through customary law on agricultural productivity in Burkina Faso. We use panel data of 15,627 agricultural households over the period 2019–2021. Four propensity score matching methods are used: the nearest neighbor method, the stratification method, the radius method and the kernel method. The instrumental variables technique was used to control for endogeneity. Overall, the results indicate that household land security improves agricultural productivity. The minimum gain in agricultural productivity is estimated to be 50,030 FCFA per agricultural asset per season for households with customary land tenure. In terms of economic policy implications, the results call on the authorities in charge of conducting agricultural policies to promote comprehensive land policies by adapting them to local contexts through the recognition of customary institutions for rural land management.
JEL Classification: Q12, Q15, K11
Digital Pulse Compression: Linear Frequency Modulation Approach
Authors: P Mallikarjuna Gowda C. , Siddesh G K , Anu H , Chaithanya S , Gill Rana , Khan M. Ijaz , Eldin Sayed M 
Published: March 2023

Abstract
In radar system a challenging task is to achieve a good range resolution with a shorter pulse which needs more peak power. High peak power makes the design of transceivers complex because the devices used to build transceivers are able to withstand with high peak power. In literature pulse compression method is widely used to minimize the problem of using high peak power signal. In this paper, the problem of generating a high peak power signal with shorter duration, which is used to detect only moving targets has been addressed by proposing a novel radar pulse compression method using Linear Frequency Modulation with improved range resolution with a basic construction of a pulse processor which is analogous to a standard matched filter, and is reformed to suit an application. Multiple code types and lengths needed are used due to the flexibility in the design which reduce an uncertainties affected by the use of high pulse repetition frequencies.
HNRNPA2B1-mediated m6A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis
Authors: Li Ke , Gong Quan , Xiang Xu-Dong , Guo Gang , Liu Jia , Zhao Li , Li Jun , Chen Nan , Li Heng , Zhang Li-Juan , Zhou Chun-Yan , Wang Zhi-Yong , Zhuang Li 
Published: March 2023

Abstract
Background
Increasing data imply that heterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1) as a nuclear N6-methyladenosine (m6A) reader acts crucial roles in cancer progression. However, the role and underlying mechanism by which HNRNPA2B1-mediated m6A modification of lncRNA contributes to non-small cell lung cancer (NSCLC) remain undocumented.
Methods
The association of HNRNPA2B1 expression with the clinicopathological characteristics and prognosis in patients with NSCLC was determined by qRT-PCR, Western blot, immunohistochemistry and public datasets. The role of HNRNPA2B1 in NSCLC cells was assessed by the in vitro experiments and in vivo tumorigenesis and metastasis models. The m6A-lncRNA epi-transcriptomic microarray was employed to screen HNRNPA2B1-mediated m6A modification of lncRNAs, which were verified by methylated RNA immunoprecipitation (Me-RIP), RT-qPCR and rescue experiments in NSCLC cells. lncRNA MEG3-specific binding with miR-21-5p was validated by luciferase gene report and RIP assays. The effects of HNRNPA2B1 and (or) lncRNA MEG3 on miR-21-5p/PTEN/PI3K/AKT signaling were examined by RT-qPCR and Western blot analyses.
Results
We found that upregulation of HNRNPA2B1 was associated with distant metastasis and represented an independent prognostic factor for poor survival in patients with NSCLC. Knockdown of HNRNPA2B1 impaired cell proliferation and metastasis of NSCLC cells in vitro and in vivo, whereas ectopic expression of HNRNPA2B1 possessed the opposite effects. Mechanical investigations revealed that lncRNA MEG3 was identified as an m6A target of HNRNPA2B1 and inhibition of HNRNPA2B1 decreased the m6A level of lncRNA MEG3 but increased its expression levels. Furthermore, lncRNA MEG3 acted as a sponge of miR-21-5p, and knockdown of lncRNA MEG3 attenuated sh-HNRNPA2B1-caused inhibitory effects on cell colony formation and invasion. Elevated expression of miR-21-5p indicated poor survival in patients with NSCLC and inhibition of miR-21-5p counteracted si-MEG3-induced PTEN downregulation and PI3K/AKT signaling activation in NSCLC cells.
Conclusions
Our findings uncover that HNRNPA2B1-mediated m6A modification of lncRNA MEG3 promotes tumorigenesis and metastasis of NSCLC cells by regulating miR-21-5p/PTEN axis.
Improving Efficiency and Reducing Costs in Robotic Surgery: A Lean Six Sigma Approach to Optimize Turnover Time
Authors: Sanchez Alexis , Herrera Luis , Teixeira Andre , Cheatham Michael , Gibson Desren , Lam Victoria , Guevara Oriana 
Published: March 2023

Abstract

Operating room (OR) turnover time (TOT) is the time it takes to prepare an OR for the next surgery after the previous one has been completed. Reducing OR TOT can improve the efficiency of the OR, reduce costs and improve surgeons’ and patients’ satisfaction. To evaluate the effectiveness of an Operating Room (OR) Turnover Time (TOT) reduction initiative using the Lean Six Sigma methodology (DMAIC) in the bariatric and thoracic service lines. Performance improvement strategies consisted on simplifying steps (surgical tray optimization) and concurrent steps (parallel task execution). We compared two non-consecutive months (pre-implementation and post-implementation). A paired t-test was used to assess whether the difference in the measurements was statistically significant. The study found that TOT was reduced by 15.6% from an average of 35.6 minutes with a standard deviation of 8.1 to an average of 30.09 minutes with a standard deviation of 9.7 (p < 0.05). Specifically, in the bariatric service line, TOT was reduced by 17.15% and in the thoracic service line, TOT was reduced by 9.6%. No adverse events related to the initiative were reported. The results of this study indicate that the TOT reduction initiative was effective in reducing TOT. The efficient use of operating rooms is crucial in hospital management, as it not only impacts finances but also affects the satisfaction of surgical teams and patients. This study shows the effectiveness of Lean Six Sigma methodology in reducing TOT and improving the efficiency in the OR.
Depolymerization of PET wastes catalysed by Sn and Ag doped ZnO nanoparticles and evaluation of Embryonic Toxicity using Zebrafish
Authors: Vinitha V. , Anbarasu M. , Priya P. , Preeyanghaa M. , Neppolian B. , Prathap Lavanya , Sundaram K. Meenakshi , Sivamurugan V. 
Published: March 2023

Abstract
The present investigation focused on the catalytic evaluation of Sn and Ag doped ZnO for depolymerization of polyethylene terephthalate (PET) polyester wastes and embryotoxic evaluation of the doped ZnO nanoparticles using Zebrafish (Danio rerio) embryo model. Bimetallic ZnO NPs doped at 1 and 2 mol% of Sn and Ag synthesized by sol-gel method and characterized by XRD, UV-Vis, FT-IR, SEM-EDS and TEM. Diffraction studies confirmed doped ZnOs retained wurtzite structure as pristine ZnO. However, the electronic spectra showed that the optical bandgap reduced from 3.31 to 3.20 eV upon 2 mol% Sn and Ag doping. SEM-EDS study confirmed elemental composition of Ag and Sn doped ZnO as well as average crystallite size of 60–70 and 115–125 nm for 1 and 2 mol% doped ZnO NPs. Glycolytic and aminolytic depolymerization of PET wastes afforded 90% of bis(2-hydroxyethyl) terephthalate (BHET) and 95% of bis(2-hydroxyethyl) terephthalamide (BHETA) respectively catalysed by 2mol% Sn and Ag doped ZnO nanoparticles. The Sn doped ZnO NPs showed comparatively higher mortality than Ag doped ZnO without any developing deformity in zebrafish embryos.