bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN PEMBELAJARAN FIQH THAHARAH DALAM MENJAGA KEBERSIHAN DI SMP PERMATA INSANI ISLAMIC SCHOOL TANGERANG
Authors: Maemunah Maemunah - , Anwariyah Siti Aan , Syaripudin Uus 
Published: June 2023

This study aimed to determine the relationship between Fiqh (thaharah) learning and Awareness of Maintaining Cleanliness in Schools for Grade VII Students at SMP Permata Insani Islamic School Tangerang. This research is field research with a correlational quantitative research design. This research uses correlational research or relationship search because it is carried out to determine the strata of the relationship between two variables without making changes, additions, or manipulations to existing data. The results of the research that have been analyzed in the formulation of the problem are that there is found a positive correlation between learning fiqh thaharah with awareness of maintaining cleanliness in schools in class VII students at SMP Permata Insani Islamic School Tangerang, where the value of r (Pearson Correlation) is 0.454 there is a medium category and based on the table of interpretation of the coefficient of the value of r.
Influence of tension-band plates on the mechanical loading of the femoral growth plate during guided growth due to coronal plane deformities
Authors: Hucke Lucie , Holder Jana , van Drongelen Stefan , Stief Felix , Gámez Antonio J. , Huß Armin , Wittek Andreas 
Published: June 2023

Introduction: Correction of knee malalignment by guided growth using a tension-band plate is a common therapy to prevent knee osteoarthritis among other things. This approach is based on the Hueter-Volkmann law stating that the length growth of bones is inhibited by compression and stimulated by tension. How the locally varying mechanical loading of the growth plate is influenced by the implant has not yet been investigated. This study combines load cases from the gait cycle with personalized geometry in order to investigate the mechanical influence of the tension-band plates.Methods: Personalized finite element models of four distal femoral epiphyses of three individuals, that had undergone guided growth, were generated. Load cases from the gait cycles and musculoskeletal modelling were simulated with and without implant. Morphological features of the growth plates were obtained from radiographs. 3D geometries were completed using non-individual Magnetic Resonance Images of age-matched individuals. Boundary conditions for the models were obtained from instrumented gait analyses.Results: The stress distribution in the growth plate was heterogenous and depended on the geometry. In the insertion region, the implants locally induced static stress and reduced the cyclic loading and unloading. Both factors that reduce the growth rate. On the contralateral side of the growth plate, increased tension stress was observed, which stimulates growth.Discussion: Personalized finite element models are able to estimate the changes of local static and cyclic loading of the growth plate induced by the implant. In future, this knowledge can help to better control growth modulation and avoid the return of the malalignment after the treatment. However, this requires models that are completely participant-specific in terms of load cases and 3D geometry.
The response of human macrophages to 3D printed titanium antibacterial implants does not affect the osteogenic differentiation of hMSCs
Authors: Garmendia Urdalleta Amaia , Van Poll Mathijs , Fahy Niamh , Witte-Bouma Janneke , Van Wamel Willem , Apachitei Iulian , Zadpoor Amir A. , Fratila-Apachitei Lidy E. , Farrell Eric 
Published: June 2023

Macrophage responses following the implantation of orthopaedic implants are essential for successful implant integration in the body, partly through intimate crosstalk with human marrow stromal cells (hMSCs) in the process of new bone formation. Additive manufacturing (AM) and plasma electrolytic oxidation (PEO) in the presence of silver nanoparticles (AgNPs) are promising techniques to achieve multifunctional titanium implants. Their osteoimmunomodulatory properties are, however, not yet fully investigated. Here, we studied the effects of implants with AgNPs on human macrophages and the crosstalk between hMSCs and human macrophages when co-cultured in vitro with biofunctionalised AM Ti6Al4V implants. A concentration of 0.3 g/L AgNPs in the PEO electrolyte was found to be optimal for both macrophage viability and inhibition of bacteria growth. These specimens also caused a decrease of the macrophage tissue repair related factor C-C Motif Chemokine Ligand 18 (CCL18). Nevertheless, co-cultured hMSCs could osteogenically differentiate without any adverse effects caused by the presence of macrophages that were previously exposed to the PEO (±AgNPs) surfaces. Further evaluation of these promising implants in a bony in vivo environment with and without infection is highly recommended to prove their potential for clinical use.
Effects of orthokeratology lenses on tear film and tarsal glands and control of unilateral myopia in children
Authors: Li Li , Lai Taichen , Zou Jing , Guo Linling , Lin Zhiming , Lin Jiawen , Xue Ying 
Published: June 2023

Introduction: To investigate the effects of an orthokeratology lens on the tear film and tarsal glands and myopia control in children with unilateral myopia using an intelligent analysis model.Methods: We retrospectively reviewed the medical records from November 2020 to November 2022 of 68 pediatric patients with unilateral myopia in Fujian Provincial Hospital who had been wearing an orthokeratology lens for more than 1 year. The 68 myopic eyes were included in the treatment group, while the 68 healthy, untreated contralateral eyes were included in the control group. Tear film break-up times (TBUTs) were compared between the two groups at various intervals, and an intelligent analysis model was used to compare the deformation coefficients of 10 meibomian glands in the central area and the different positions of the glands in the two groups after 12 months of treatment. Changes in axial length and equivalent spherical power were also compared between the groups before and after 12 months of treatment.Results: In the treatment group, TBUTs differed significantly between 1 and 12 months after treatment, although no significant differences from baseline were observed at 3 or 6 months. No significant differences in TBUTs were observed at any time point in the control group. After 12 months of treatment, significant between-group differences were observed for glands 2, 3, 4, 5, 6, 7, 8, and 10 (numbered from the temporal to nasal regions). The treatment group also exhibited significant differences in deformation coefficients at different detection positions in the central region, with glands 5 and 6 exhibiting the highest deformation coefficients. Increases in axial length and equivalent spherical power were significantly greater in the control group than in the treatment group after 12 months of treatment.Discussion: Wearing orthokeratology lenses at night can effectively control myopia progression in children with unilateral myopia. However, long-term use of these lenses may lead to meibomian gland deformation and impact tear film function, and the extent of deformation may vary at different positions in the central region.
Assessment of mortality-related risk factors and effective antimicrobial regimens for treatment of bloodstream infections caused by carbapenem-resistant Pseudomonas aeruginosa in patients with hematological diseases
Authors: Zhen Sisi , Zhao Yuanqi , Chen Zhangjie , Zhang Tingting , Wang Jieru , Jiang Erlie , Zhang Fengkui , Mi Yingchang , Zhu Xiaofan , Han Mingzhe , Xiao Zhijian , Wang Jianxiang , Feng Sizhou 
Published: June 2023

BackgroundInfections caused by carbapenem-resistant Pseudomonas aeruginosa (CRPA) are related to higher mortality. The objective of this study was to explore clinical outcomes of CRPA bacteremia, identify risk factors and also, compare the efficacy of traditional and novel antibiotic regimens.MethodsThis retrospective study was conducted at a blood diseases hospital in China. The study included hematological patients who were diagnosed with CRPA bacteremia between January 2014 and August 2022. The primary endpoint was all-cause mortality at day 30. Secondary endpoints included 7-day and 30-day clinical cure. Multivariable Cox regression analysis was employed to identify mortality-related risk factors.Results100 patients infected with CRPA bacteremia were included and 29 patients accepted allogenic-hematopoietic stem cell transplantation. 24 received ceftazidime-avibactam (CAZ-AVI)-based therapy and 76 received other traditional antibiotics. 30-day mortality was 21.0%. Multivariable cox regression analysis showed neutropenia &gt;7 days after bloodstream infections (BSI) (P=0.030, HR: 4.068, 95%CI: 1.146~14.434), higher Pitt bacteremia score (P&lt;0.001, HR:1.824, 95%CI: 1.322~2.517), higher Charlson comorbidity index (P=0.01, HR: 1.613, 95%CI: 1.124~2.315) and bacteremia due to multidrug-resistant Pseudomonas aeruginosa (MDR-PA) (P=0.024, HR:3.086, 95%CI: 1.163~8.197) were identified as independent risk factors of 30-day mortality. After controlling for confounders, an additional multivariable cox regression analysis revealed definitive regimens containing CAZ-AVI were associated with lower mortality in CRPA bacteremia (P=0.016, HR: 0.150, 95%CI: 0.032~0.702), as well as in MDR-PA bacteremia (P=0.019, HR: 0.119, 95%CI: 0.020~0.709).ConclusionsFor patients with hematological diseases and CRPA bacteremia, 30-day mortality rate was 21.0% (21/100). Neutropenia &gt;7 days after BSI, higher Pitt bacteremia score, higher Charlson comorbidity index and bacteremia due to MDR-PA increased 30-day mortality. CAZ-AVI-based regimens were effective alternatives for bacteremia due to CRPA or MDR-PA.
Egoistic and altruistic behaviors in tobacco control campaign: the role of social media exposure, interpersonal communication and attitudes
Authors: Liu Shiyu , Wu Qiaofei , Luo Xinyuan , Chen Yu , Xu Jing 
Published: June 2023

IntroductionA growing body of research has examined the relationship between media exposure to health campaign information and health behaviors, yielding inconsistent findings. To address this inconsistency, it is crucial to investigate the underlying mediation and moderation mechanisms. Building upon the social diffusion model, this study explores the mediating role of interpersonal communication and the moderating role of attitudes in the relationships between health behavioral outcomes and exposure to campaign information.MethodA tobacco control social media campaign were conducted and assessed via an online survey. Specifically, the survey was conducted from the day after the end of the campaign. Respondents were recruited via Sojump using convenience and snowball sampling. Eligible participants were non-smokers and quitters residing in China and had been exposed to the campaign information. Data were analyzed using the R software.ResultsA total of 326 eligible participants were included in the final analysis. The results suggest that social media exposure to campaign information is indirectly associated with both egoistic and altruistic behavioral intentions through interpersonal communication. However, attitudes toward tobacco control weaken the association between social media exposure to campaign information and interpersonal communication about tobacco risks. Furthermore, the indirect effect of social media exposure to campaign information on egoistic and altruistic behavioral intentions, mediated by interpersonal communication about tobacco risks, is contingent upon attitudes toward tobacco control.ConclusionThis study tests and supports the proposition that interpersonal communication mediates the effects of campaign information exposure on health behaviors in the context of China, which contributes to the existing literature on the health effects of campaign information exposure and provides implications for the design of health campaigns to more effectively promote healthy behaviors.
Effect of trehalose on heart functions in rats model after myocardial infarction: assessment of novel intraventricular pressure and heart rate variability
Authors: Farag Ahmed , Mandour Ahmed S. , Kaneda Masahiro , Elfadadny Ahmed , Elhaieg Asmaa , Shimada Kazumi , Tanaka Ryou 
Published: June 2023

BackgroundMyocardial infarctions remain a leading cause of global deaths. Developing novel drugs to target cardiac remodeling after myocardial injury is challenging. There is an increasing interest in exploring natural cardioprotective agents and non-invasive tools like intraventricular pressure gradients (IVPG) and heart rate variability (HRV) analysis in myocardial infarctions. Trehalose (TRE), a natural disaccharide, shows promise in treating atherosclerosis, myocardial infarction, and neurodegenerative disorders.ObjectivesThe objective of this study was to investigate the effectiveness of TRE in improving cardiac functions measured by IVPG and HRV and reducing myocardial remodeling following myocardial infarction in rat model.MethodsRats were divided into three groups: sham, myocardial infarction (MI), and trehalose-treated MI (TRE) groups. The animals in the MI and TRE groups underwent permanent ligation of the left anterior descending artery. The TRE group received 2% trehalose in their drinking water for four weeks after the surgery. At the end of the experiment, heart function was assessed using conventional echocardiography, novel color M-mode echocardiography for IVPG evaluation, and HRV analysis. After euthanasia, gross image scoring, histopathology, immunohistochemistry, and quantitative real-time PCR were performed to evaluate inflammatory reactions, oxidative stress, and apoptosis.ResultsThe MI group exhibited significantly lower values in multiple IVPG parameters. In contrast, TRE administration showed an ameliorative effect on IVPG changes, with results comparable to the sham group. Additionally, TRE improved HRV parameters, mitigated morphological changes induced by myocardial infarction, reduced histological alterations in wall mass, and suppressed inflammatory reactions within the infarcted heart tissues. Furthermore, TRE demonstrated antioxidant, anti-apoptotic and anti-fibrotic properties.ConclusionThe investigation into the effect of trehalose on a myocardial infarction rat model has yielded promising outcomes, as evidenced by improvements observed through conventional echocardiography, histological analysis, and immunohistochemical analysis. While minor trends were noticed in IVPG and HRV measurements. However, our findings offer valuable insights and demonstrate a correlation between IVPG, HRV, and other traditional markers of echo assessment in the myocardial infarction vs. sham groups. This alignment suggests the potential of IVPG and HRV as additional indicators for future research in this field.
Prenatal exposure to polybrominated diphenyl ethers and inattention/hyperactivity symptoms in mid to late adolescents
Authors: Park Seonyoung , Cowell Whitney , Margolis Amy E. , Sjodin Andreas , Jones Richard , Rauh Virginia , Wang Shuang , Herbstman Julie B. 
Published: June 2023

IntroductionPrenatal exposure to polybrominated diphenyl ethers (PBDEs) has been associated with increased symptoms of attention deficit/hyperactivity disorder (ADHD) in early to middle childhood, as well as early adolescence. However, data are limited for the long-lasting impact of exposure on outcomes assessed across the entire adolescent period and the sex-specificity of such associations.MethodsWe investigated the association between continuous natural-log-transformed cord plasma PBDE concentrations and ADHD rating scale 4th edition (ADHD-RS-IV) score from mid adolescence (approximately 11 years old) to late adolescence (approximately 17 years old). The study sample includes a subset (n = 219) of the African American and Dominican children enrolled in the Columbia Center for Children's Environmental Health Mothers and Newborns birth cohort. We used generalized estimating equations to account for the repeated measure of ADHD-RS scores. We examined interactions between exposure to PBDE and sex using cross-product terms and sex-stratified models. In addition, we used linear regression using an age-stratified sample as a sensitivity analysis.Results and DiscussionAssociations between prenatal exposure and parents’ reports of ADHD symptoms varied by sex (p-interaction &lt;0.20), with positive relationships observed among girls but not boys from sex-stratified models. Our finding suggests prenatal exposure to PBDE may affect ADHD symptoms assessed during middle to late adolescence and the sex-specificity of such impact. Our results can be confirmed by future studies with larger and more diverse samples.
A promising self-nanoemulsifying adjuvant with plant-derived saponin D boosts immune response and exerts an anti-tumor effect
Authors: Luo Xing , Song Zhen , Zeng Xiaogqiang , Ye Yan , Zheng Hailin , Cai Dingyi , Yuan Qingpeng , Li Haibo , Tong Yanan , Lu Dongshui , Liu Yuheng , Zeng Hao , Yang Yun , Sun Hongwu , Zou Quanming 
Published: June 2023

ObjectivesThe low immunogenicity of tumor antigens and unacceptable toxicity of adjuvants has hindered the application and development of tumor vaccines. Hence, we designed a novel anti-tumor vaccine composed of a plant-derived immunostimulant molecular nanoadjuvant (a self-nanoemulsifying system, SND) and the antigen OVA, to reinvigorate the immune response and inhibit tumor progression.MethodsIn this study, this novel nanoadjuvant with Saponin D (SND) was designed and prepared by low-energy emulsification methods. Several important characteristics of the SND, including morphology, size, polymer dispersity index (PDI), zeta potential, and stability, were estimated, and the cytotoxicity of the SND was evaluated by MTT assay. Additionally, the immune response in terms of antibody titer levels and cellular immunity were evaluated in vivo after immunization with the vaccine, and the preventative and therapeutic effects of this novel vaccine against tumors were estimated. Finally, the antigen release profile was determined by IVIS imaging and by in vivo assay. ResultsThis SND nanoadjuvant had good characteristics including the average particle size of 26.35 ± 0.225 nm, narrow distribution of 0.221 ± 1.76, and stability zeta potential of -12.9 ± 0.83 mV. And also, it had good stability (size, PDI, zeta potential, antigen stability) and low toxicity in vitro and in vivo, and delayed antigen release in vivo. The humoral immune response (IgG, IgG1, IgG2a, and IgG2b) and cellular immune level (cytokines of splenocytes including IFN-γ, IL-4, IL-1β andIL-17A) were both improved greatly after injected immunization at 0, 14, 28 days with the novel nanoadjuvant and antigen OVA. Importantly, this novel nanoadjuvant combined with OVA might lead to the induction of the prevent and treatment efficacy in the E.G7-OVA tumor-bearing mice. ConclusionsThese results suggested that this novel nanoadjuvant encapsulated natural plant immunostimulant molecular OPD could be a good candidate of tumor vaccine adjuvant for reinvigorating the immune response and powerfully inhibiting tumor growth effect.
Identification of common genetic characteristics of rheumatoid arthritis and major depressive disorder by bioinformatics analysis and machine learning
Authors: Jiang Wen , Wang Xiaochuan , Tao Dongxia , Zhao Xin 
Published: June 2023

IntroductionDepression is the most common comorbidity of rheumatoid arthritis (RA). In particular, major depressive disorder (MDD) and rheumatoid arthritis share highly overlapping mental and physical manifestations, such as depressed mood, sleep disturbance, fatigue, pain, and worthlessness. This overlap and indistinguishability often lead to the misattribution of physical and mental symptoms of RA patients to depression, and even, the depressive symptoms of MDD patients are ignored when receiving RA treatment. This has serious consequences, since the development of objective diagnostic tools to distinguish psychiatric symptoms from similar symptoms caused by physical diseases is urgent.MethodsBioinformatics analysis and machine learning.ResultsThe common genetic characteristics of rheumatoid arthritis and major depressive disorder are EAF1, SDCBP and RNF19B.DiscussionWe discovered a connection between RA and MDD through immune infiltration studies: monocyte infiltration. Futhermore, we explored the correlation between the expression of the 3 marker genes and immune cell infiltration using the TIMER 2.0 database. This may help to explain the potential molecular mechanism by which RA and MDD increase the morbidity of each other.
Designing of carbon fiber-reinforced polymer (CFRP) composites for a second-life in the aeronautic industry: strategies towards a more sustainable future
Authors: Borges Carolina , Chícharo A. , Araújo A. , Silva J. , Santos R. M. 
Published: June 2023

Over the last few years, the use of carbon fiber-reinforced polymer composites (CFRP) in the aeronautic sector has significantly increased, given these materials’ outstanding properties. Consequently, the accumulation of composite residues is becoming an environmental hurdle. Therefore, in a world where sustainability and circularity remain on the lead, the replacement of thermosets by thermoplastics as polymeric matrices emerges as a promising technique, given the recyclability of these materials. Following this perspective, in this work, carbon fiber-reinforced polymer (CFRP) composite “residues” were incorporated into a poly(etheretherketone) (PEEK) matrix, as a strategy towards a more sustainable future, aiming at developing novel compounds for the aeronautic industry. The influence of two different fiber sizes (&lt;600 and 600–1000 μm) on the neat PEEK properties was assessed through formulations developed using a co-rotating twin screw-extruder, under optimized processing conditions. Furthermore, the potential thermo-oxidative degradation, and the recycling feasibility of the neat PEEK and its compounds, were evaluated by submitting the materials to several thermo-mechanical cycles. The results showed that PEEK compounds were successfully prepared, and presented a good fiber distribution and absence of fiber agglomerates. A positive impact on the mechanical performance of PEEK was found by the incorporation of 3.3 wt.% of short carbon fibers (sCF) with larger sizes (600–1000 μm). The reprocessing of neat PEEK and its compounds for 15 consecutive cycles demonstrated their remarkable thermo-mechanical stability, without any sign of degradation or irreversible loss of properties. The fiber length and fiber length distribution of reprocessed compounds showed that major variations occurred after the first extrusion cycle, especially for larger sizes.