bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Training of Reading Beam Notations on Pranada Lines for Children in the Community Reading Park
Authors: Syaida Oktira Yona , Efendi Nofriza 
Published: September 2023

Block notation is one of the elements in music. Creativity in singing needs to be trained from an early age, with interest and talent, creativity is also very influential with experience. The purpose of this community service implementation is to provide training to read block notation on the rhyme line for children at the community reading park (TBM) in order to children are accustomed to seeing block notation from an early age, students are able to differentiate the tone "do" to tone "re" to tone "mi" and so on, so it is not new thing for students to see the notation of blocks on the sheet music. The implementation method of this community service using the lecture method, demonstration method and practice (data is in qualitative form with descriptive methods) by describing the data in detail and in detail in accordance with the implementation of community service activities. This training explains the shape of block notation, symbols in music, the symbol functions to determine the high and low of the voice, beam notation is divided into 3 parts consisting of flags, stems, and notation heads. Furthermore , it provides training on the value, shape and location of the beat on the line. From this community service activity, the authors got the results, namely: 1) adding knowledge to students in the form of block notation, 2) students being able to read block notation with slash lines and distinguishing the shape and location of tones on the rhyme line, 3) developing interest and students’ talent to appear in front of their friends to sing, 4) students are able to make block notation well, 5) this training produces students who are able to practice solfegio exercises well, 6) this training is participated by elementary school students consists of low class and high class.
Transmettre des savoirs stylistiques à des élèves clavecinistes et organistes : l’apport de Bernardo Pasquini (1637–1710)
Authors: Falcone Fabio Antonio 
Published: September 2023

De nombreuses sources historiques saluent le style spécifique de jeu et d’accompagnement de Pasquini en le définissant comme « la manière la plus authentique, la plus belle et la plus noble de jouer et d’accompagner » (Gasparini, 1722). Que pouvons-nous déduire de l’analyse de ses ouvrages pédagogiques concernant la construction des savoirs nécessaires à la réalisation d’une improvisation stylistiquement « correcte » ? À travers une analyse didactique du corpus de sources pédagogiques pour clavier de Pasquini, cet article se propose de décrire les objets matériels et symboliques aménagés par le maître afin de favoriser la construction de connaissances stylistiques chez l’élève.
High‐Performance Artificial Ligament Made from Helical Polyester Fibers Wrapped with Aligned Carbon Nanotube Sheets
Authors: Wang Liyuan , Jiang Hongyu , Wan Fang , Sun Hongji , Yang Yiqing , Li Wenjun , Qian Zheyan , Sun Xuemei , Chen Peining , Chen Shiyi , Peng Huisheng 
Published: September 2023

AbstractRepairing high‐load connective tissues, such as ligaments, by surgically implanting artificial grafts after injury is challenging because they lack biointegration with host bones for stable interfaces. Herein, a high‐performance helical composite fiber (HCF) ligament by wrapping aligned carbon nanotube (CNT) sheets around polyester fibers is proposed. Anterior cruciate ligament (ACL) reconstruction surgery shows that HCF grafts could induce effective bone regeneration, thus allowing the narrowing of bone tunnel defects. Such repair of the bone tunnel is in strong contrast to the tunnel enlargement of more than 50% for commercial artificial ligaments made from bare polyester fibers. Rats reconstructed with this HCF ligament show normal jumping, walking, and running without limping. This work allows bone regeneration in vivo through a one‐step surgery without seeding cells or transforming growth factors, thereby opening an avenue for high‐performance artificial tissues.
Near Infrared Emissive Lanthanide Luminescence Nanoparticle Used in Early Diagnosis and Brain Temperature Detection for Ischemic Stroke
Authors: Li Shen‐Jie , Li Fang , Kong Na , Liu Jian‐Ren , Zhu Xingjun 
Published: September 2023

AbstractIschemic stroke (IS) is one of the most dangerous medical conditions resulting in high mortality and morbidity. The increased brain temperature after IS is closely related to prognosis, making it highly significant for the early diagnosis and the progression evaluation of IS. Herein, a temperature‐responsive near infrared (NIR) emissive lanthanide luminescence nanoparticle is developed for the early diagnosis and brain temperature detection of IS. After intravenous injection, the nanoparticles can pass through the damaged blood–brain barrier of the ischemic region, allowing the extravasation and enrichment of nanoparticles into the ischemic brain tissue. The NIR luminescence signals of the nanoparticles are used not only to judge the location and severity of the cerebral ischemic injury but also to report the brain temperature variation in the ischemic area through a visualized way. The results show that the designed nanoparticles can be used for the early diagnosis of ischemic stroke and minimally invasive temperature detection of cerebral ischemic tissues in transient middle cerebral artery occlusion mice model, which is expected to make the clinical diagnosis of ischemic stroke more rapid and convenient, more accurately evaluate the state of brain injury in stroke patients and also guide stroke hypothermia treatment.
An AND Logic Gate for Magnetic‐Resonance‐Imaging‐Guided Ferroptosis Therapy of Tumors
Authors: Fan Qingdeng , Xiong Wei , Zhou Huimin , Yang Jing , Feng Jie , Li Zongheng , Wu Lihe , Hu Fang , Duan Xiaopin , Li Bo , Fan Junbing , Xu Yikai , Chen Xiaoyuan , Shen Zheyu 
Published: September 2023

AbstractTo improve the magnetic resonance imaging (MRI) efficiency and ferroptosis therapy efficacy of exceedingly small magnetic iron oxide nanoparticles (IO, <5 nm) for tumors via enhancing the sensitivity of tumor microenvironment (TME) responsiveness, inspired by molecular logic gates, a self‐assembled IO with an AND logic gate function is designed and constructed. Typically, cystamine (CA) is conjugated onto the end of poly(2‐methylthio‐ethanol methacrylate) (PMEMA) to generate PMEMA‐CA. The PMEMA‐CA is grafted onto the surface of brequinar (BQR)‐loaded IO to form IO‐BQR@PMEMA. The self‐assembled IO‐BQR@PMEMA (SA‐IO‐BQR@PMEMA) is obtained due to the hydrophobicity of PMEMA. The carbon–sulfur single bond of PMEMA‐CA can be oxidized by reactive oxygen species (ROS) in the TME to a thio–oxygen double bond, resulting in the conversion from being hydrophobic to hydrophilic. The disulfide bond of PMEMA‐CA can be broken by the glutathione (GSH) in the TME, leading to the shedding of PMEMA from the IO surface. Under the dual actions of ROS and GSH in TME (i.e., AND logic gate), SA‐IO‐BQR@PMEMA can be disassembled to release IO, Fe2+/3+, and BQR. In vitro and in vivo results demonstrate the AND logic gate function and mechanism, the high T1 MRI performance and exceptional ferroptosis therapy efficacy for tumors, and the excellent biosafety of SA‐IO‐BQR@PMEMA.
Micro‐Droplets Parameters Monitoring in a Microfluidic Chip via Liquid‐Solid Triboelectric Nanogenerator
Authors: Liu Wenkai , Li Hengyu , Gao Qi , Zhao Da , Yu Yang , Xiang Qin , Cheng Xiaojun , Wang Zhong Lin , Long Wei , Cheng Tinghai 
Published: September 2023

AbstractThe monitoring of micro‐droplets parameters is significant to the development of droplet microfluidics. However, existing monitoring methods have drawbacks such as high cost, interference with droplet movement, and even the potential for cross‐contamination. Herein, a micro‐droplets monitoring method (MDMM) based on liquid‐solid triboelectric nanogenerator (LS‐TENG) is proposed, which can realize non‐invasive and self‐powered monitoring of micro‐droplets in a microfluidic chip. The droplet frequency is monitored by voltage pulse frequency and a mathematical model is established to monitor the droplet length and velocity. Furthermore, this work constructs micro‐droplets sensor (MDS) based on the MDMM to carry out the experiment. The coefficients of determination (R2) of the fitting curves of the micro‐droplets frequency, length, and velocity monitoring are 0.998, 0.997, and 0.995, respectively. To prove the universal applicability of the MDMM, the micro‐droplets generated by different liquid media and channel structures are monitored. Eventually, a micro‐droplet monitoring system is built, which can realize the counting of micro‐droplets and the monitoring of droplet frequency and length. This work provides a novel approach for monitoring micro‐droplets parameters, which holds the potential to advance developments in the field of microfluidics.
Covalently Functionalized Nanopores for Highly Selective Separation of Monovalent Ions
Authors: Guo Liping , Liu Yuancheng , Zeng Haiou , Zhang Shengping , Song Ruiyang , Yang Jing , Han Xiao , Wang Ying , Wang Luda 
Published: September 2023

AbstractBiological ion channels possess prominent ion transport performances attributed to their critical chemical groups across the continuous nanoscale filters. However, it is still a challenge to imitate these sophisticated performances in artificial nanoscale systems. Herein, this work develops the strategy to fabricate functionalized graphene nanopores in pioneer based on the synergistic regulation of the pore size and chemical properties of atomically thin confined structure through decoupling etching combined with in situ covalent modification. The modified graphene nanopores possess asymmetric ion transport behaviors and efficient monovalent metal ions sieving (K+/Li+ selectivity ≈48.6). Meanwhile, it also allows preferential transport for cations, the resulting membranes exhibit a K+/Cl− selectivity of 76 and a H+/Cl− selectivity of 59.3. The synergistic effects of steric hindrance and electrostatic interactions imposing a higher energy barrier for Cl− or Li+ across nanopores lead to ultra‐selective H+ or K+ transport. Further, the functionalized graphene nanopores generate a power density of 25.3 W m−2 and a conversion efficiency of 33.9%, showing potential application prospects in energy conversion. The theoretical studies quantitatively match well with the experimental results. The feasible preparation of functionalized graphene nanopores paves the way toward direct investigation on ion transport mechanism and advanced design in devices.
Testing the reliability and validity of the modified Amsterdam Inventory for Auditory Disability and Handicap in career firefighters in the United States
Authors: Kyung Minjung , Chin Dal Lae , Phelps Stephanie , Hong OiSaeng 
Published: September 2023

AbstractBackgroundFirefighters are routinely exposed to loud noise that put them at risk for hearing loss. A reliable and valid measure to assess firefighters' hearing function is important. This study aims to test the reliability and validity of the modified Amsterdam Inventory for Auditory Disability and Handicap ((m)AIADH) in firefighters.MethodA cross‐sectional study was conducted using a convenience sample of 239 career firefighters from six partnered fire departments in Central Texas and Northern California. The internal consistency, convergent and criterion validity, and the ability to discriminate groups by measured hearing, perceived hearing, and a combination of measured and perceived hearing, were examined using the total score and score for each of the five subscales of the (m)AIADH.ResultsThe study participants were primarily men (93%). Satisfactory internal consistency was revealed for the (m)AIADH with Cronbach's alpha above 0.80 for all five subscales. Criterion analysis presented a moderate correlation between the (m)AIADH and the average of hearing threshold at high frequencies (4, 6, and 8 kHz). For convergent validity, the (m)AIADH was moderately to highly related with perceived hearing. There were statistically significant differences in the total (m)AIADH score and the five subscales for measured hearing thresholds except for “intelligibility in quiet.” The (m)AIADH also showed a discriminative ability to distinguish between the group with good perceived hearing and the group with bad perceived hearing.ConclusionThe (m)AIADH is a reliable and valid measure to assess various dimensions of hearing function among firefighters.
Adapting direct filtration to increasing source water dissolved organic carbon using clarification and granular activated carbon
Authors: Anderson Lindsay E. , Tchonlla Manda , Earle Martin , Swinamer Ryan , Gagnon Graham A. 
Published: September 2023

AbstractChanging source water quality namely through increasing natural organic matter (NOM) concentration challenges surface water treatment, especially direct filtration. We conducted a pilot‐scale assessment of various adaptation strategies (e.g., clarification, granular activated carbon [GAC] filtration) for direct filtration facilities under the stress of rising NOM levels. Recognizing that changing source water can impact broader aspects of treatment, we considered the implications of Fe and Mn removal via KMnO4 pre‐oxidation. GAC media showed promise as an adaptation strategy, providing ~60% removal of dissolved organic carbon (DOC), and a significant reduction in disinfection by‐product formation potential (DBPfp). However, KMnO4 pretreatment showed limited Mn and Fe removal, and filters with GAC media released dissolved Mn at up to ~30% of prefilter levels. These data suggest that using GAC may come with the risk of poor Mn removal performance if Mn is not removed during pretreatment. This work highlights the complexities anticipated under emerging climate pressures and emphasizes the need for comprehensive treatment solutions that consider factors beyond NOM.
Terrorism and child mortality
Authors: Meierrieks Daniel , Schaub Max 
Published: September 2023

AbstractHow does terrorism affect child mortality? We use geo‐coded data on terrorism and spatially disaggregated data on child mortality to study the relationship between both variables for 52 African countries between 2000 and 2017 at the 0.5 × 0.5° grid level. Our estimates suggest that moderate increases in terrorism are linked to several thousand additional annual deaths of children under the age of five. A panel event‐study points to economic effects that are larger and compound over time. Interrogating our data, we show that the direct impact of terrorism tends to be very small. Instead, we theorize that terrorism causes child mortality primarily by triggering adverse behavioral responses by parents, medical workers, and policymakers. We provide tentative evidence in support of this argument.
AaLaeA targets AaFla1 to mediate the production of antitumor compound in Alternaria alstroemeria
Authors: Feng Can , Zheng Wen , Han Long , Wang Jian‐kang , Zha Xing‐ping , Xiao Qing , He Zhang‐jiang , Kang Ji‐chuan 
Published: September 2023

AbstractEndophytic fungi are an important source of novel antitumor substances. Previously, we isolated an endophytic fungus, Alternaria alstroemeria, from the medicinal plant Artemisia artemisia, whose crude extracts strongly inhibited A549 tumor cells. We obtained a transformant, namely AaLaeAOE26, which completely loses its antitumor activity due to overexpression of the global regulator AaLaeA. Re‐sequencing analysis of the genome revealed that the insertion site was in the noncoding region and did not destroy any other genes. Metabolomics analysis revealed that the level of secondary antitumor metabolic substances was significantly lower in AaLaeAOE26 compared with the wild strain, in particular flavonoids were more downregulated according to the metabolomics analysis. A further comparative transcriptome analysis revealed that a gene encoding FAD‐binding domain protein (Fla1) was significantly downregulated. On the other hand, overexpression of AaFla1 led to significant enhancement of antitumor activity against A549 with a sevenfold higher inhibition ratio than the wild strain. At the same time, we also found a significant increase in the accumulation of antitumor metabolites including quercetin, gitogenin, rhodioloside, liensinine, ginsenoside Rg2 and cinobufagin. Our data suggest that the global regulator AaLaeA negatively affects the production of antitumor compounds via controlling the transcription of AaFla1 in endophytic A. alstroemeria.
Preoperative prognostic nutritional index predicts survival of patients with intrahepatic cholangiocarcinoma after curative resection
Authors: Akgül Özgür , Bagante Fabio , Olsen Griffin , Cloyd Jordan M. , Weiss Matthew , Merath Katiuscha , Alexandrescu Sorin , Marques Hugo P. , Aldrighetti Luca , Maithel Shishir K. , Pulitano Carlo , Bauer Todd W. , Shen Feng , Poultsides George A. , Soubrane Olivier , Martel Guillaume , Koerkamp B. Groot , Guglielmi Alfredo , Itaru Endo , Pawlik Timothy M. 
Published: September 2023

BackgroundIntrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy. We sought to examine the association between preoperative prognostic nutritional index (PNI) and long‐term overall survival among patients with ICC who underwent curative‐intent resection.MethodsPatients who underwent hepatectomy for ICC between 1990 and 2015 were identified using an international multi‐institutional database. Clinic‐pathological characteristics and long‐term outcomes of patients with PNI ≥ 40 and <40 were compared using univariable and multivariable analyses.ResultsAmong 637 patients, 53 patients had PNI < 40 (8.3%) and 584 patients had PNI ≥ 40 (91.7%). While there was no difference between PNI groups with regard to tumor size (P = .87), patients with PNI < 40 were more likely to have multifocal disease (PNI < 40, n = 16, 30.2% vs PNI ≥ 40, n = 65, 11.1%; P < 0.001), poorly differentiated or undifferentiated ICC (PNI < 40, n = 13, 25.5% vs PNI ≥ 40, n = 75, 13.1%; P = 0.020) and T2/T3/T4 disease vs patients with PNI ≥ 40 (PNI < 40, n = 38, 71.7% vs PNI ≥ 40, n = 265, 45.4%; P < 0.001). Patients with PNI ≥ 40 had better OS vs patients with PNI < 40 (5‐year OS: PNI ≥ 40: 47.5%, 95% CI, 42.2 to 52.6% vs PNI < 40: 24.6%, 95% CI, 12.1 to 39.6%; P < 0.001). On multivariable analysis, PNI < 40 remained associated with increase risk of death (HR, 1.71; 95% CI, 1.15 to 2.53; P = 0.008).ConclusionA low preoperative PNI was associated with a more aggressive ICC phenotype. After controlling for these factors, PNI remained independently associated with a markedly worse prognosis.
A negative‐doughnut distal resection margin less than 5 mm does not affect prognosis in rectal cancer
Authors: Keranmu Adili , Liu Hai‐Ning , Wu Yu‐Chen , Liu Tao‐Tao , Li Cong , Guo Tian‐An , Liu Fang‐Qi , Zheng Hong‐Tu , Xu Ye 
Published: September 2023

AimMany issues relating to the distal margin of anterior resection of the rectum still exist. We aimed to investigate whether negative distal resection margin (DRM) and positive DRM in the main specimen with negative doughnut has equivalent prognosis in patients with rectal cancer.MethodsWe included 287 patients with rectal cancer, including 69 cases with positive margins and 218 cases with negative margins, all of whom underwent regular follow‐up. Survival rate was calculated using Kaplan‐Meier survival analysis, while the log‐rank test was used to determine statistical difference. Prognostic factors were found using the Cox regression model.ResultsThere was no significant difference in clinicopathological features between the two groups with the exception of tumor location. Positive findings in the DRM with negative findings in the doughnut resection do not affect the overall survival, local recurrence, or distant metastasis. Factors relating to resection margin, such as the length of resection, negative, or positive findings, were not found to be prognostic.ConclusionGiven postoperative pathology results with positive DRM but negative findings in the doughnut resection, a second surgery was not necessary. Instead, adjuvant radiochemotherapy and close follow‐up will suffice.
Optimal surgical margin for infiltrative soft tissue sarcomas: Assessing the efficacy of excising beyond the infiltration
Authors: Iwata Shintaro , Araki Akinobu , Funatsu Hiroyuki , Yonemoto Tsukasa , Kamoda Hiroto , Itami Makiko , Ishii Takeshi 
Published: September 2023

BackgroundTumor infiltration in soft tissue sarcoma (STS) is known to correlate with an inadequate surgical margin and poor local control. This study aims to determine whether the radiological infiltration (R‐inf) in STS cor relates with histological infiltration (H‐inf) and to devise methods to determine a resection margin for infiltrative STS.MethodsWe reviewed the medical records of 145 patients with high‐grade STS. We measured the R‐inf on short‐T1 inversion recovery or gadolinium‐enhanced fat‐suppressed (GdFS) magnetic resonance imaging. In addition, we assessed H‐inf as the infiltrative growth of atypical tumor cells. The local control rate (LCR) was assessed using the Kaplan‐Meier method.ResultsA statistically significant positive correlation was found between H‐inf and R‐inf (P < 0.0001). The R‐inf obtained from the GdFS images exhibited a stronger correlation with H‐inf than that obtained from the short‐T1 inversion recovery images. Univariate and multivariate analyses revealed that a positive H‐inf significantly correlated with a poor LCR. Moreover, the contaminated margins, which included intrainfiltration margins, significantly correlated with a poor LCR compared with the wide margins.ConclusionsR‐inf as assessed by the GdFS images significantly correlates with H‐inf, suggesting that we should exercise the infiltrative STS beyond their R‐infs detected by the GdFS images.
Safety of rectum anastomosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Authors: von Breitenbuch Philipp , Piso Pompiliu , Schlitt Hans J 
Published: September 2023

AbstractBackground and ObjectivesIn highly selected patients with peritoneal carcinomatosis, cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) can be an aggressive but worthwhile treatment regimen. Resection of the rectosigmoid is frequently performed with CRS. The aim of the study was to assess the safety of the rectal anastomosis in this setting.MethodsBetween 2005 and 2016, 436 patients underwent CRS/HIPEC. Clinical data were analyzed with respect to the morbidity associated with a rectum resection.ResultsIn 436 patients, 174 rectum resections (40%) were performed with CRS, including 149 anterior resections of the rectosigmoid, 23 low anterior rectum resections, and 2 abdominoperineal rectum excisions. A total of 141 rectum anastomoses were performed; 33 patients received a permanent ostomy, and 48 patients received a protective ileostomy. After changing the operation technique of the rectum anastomosis, the number of protective ileostomies decreased from 65% to 20%. The overall postoperative morbidity was 31%. Rectal anastomotic leakages were seen in only 5% of cases.ConclusionsAnastomotic leakages of the rectum are rarely seen after CRS/HIPEC. HIPEC performed immediately after surgery seems to have no negative effect on the rectum anastomosis. Performing rectum anastomoses after CRS/ HIPEC appears to be a safe procedure.