bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective observational studies on nutrition intake and the incidence of cognitive impairment in middle-aged and older adults: A protocol for systematic review and meta-analysis
Authors: Jiang Hailun , Zhu Weiming , Li Boxuan , Deng Shizhe , Meng Xianggang , Liu Wei , Du Yuzheng , Meng Zhihong 
Published: June 2023

Introduction
According to several studies, a specific dietary pattern can reduce the risk of dementia and cognitive impairment. However, the robustness of these results has not been tested. The study intends to investigate the association between nutrition intake and cognitive impairment in middle-aged and older adults (≥45-years) and provide reliable, evidence-based references for healthcare decision-makers, researchers, and policymakers.

Review question
Are the dietary characteristics of community-dwelling adults (≥45-years) associated with the occurrence of cognitive impairment?

Objectives
The primary objective of this protocol is to synthesize the longitudinal observational evidence on the relationship between nutrition intake patterns and the incidence of cognitive impairment in middle-aged and older adults (≥45-years), and to provide detailed dietary recommendations for the prevention of cognitive impairment in this population.

Methods and analysis
Cohort studies conducted among adults (≥45-years) will be included. The following electronic databases will be searched for relevant records published by July 2023, with a restriction on language to English: Pubmed, Medline, Embase, Web of science, Cochrane Library. The studies will be selected, the data will be extracted, and the bias risk will be assessed by two independent investigators. The Meta-analysis of Observational Studies in Epidemiology guidelines will be followed to summarize observational studies, and the protocol will adhere to the recommendations from the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 statement. Endnote X9 will be used to manage data screening. We will use Review Manager 5.4 and Stata 16.0 to conduct data analysis, and a random-effects model will be applied to pool clinically homogenous studies. The results will be presented based on the form of nutrition intake. For assessing publication bias, Egger’s test and visual inspection of funnel plots will be utilized.

Ethics and dissemination
As this study does not involve primary data, ethical approval is not required. The final report will be published in a peer-reviewed journal.

Prospero registration number
A registration number of DOI 10.17605/OSF.IO/NAKC3 was assigned to it on October 15, 2022 on Prospero.
Reflective practice improves Basic Life Support training outcomes: A randomized controlled study
Authors: Thommes Marie S. , Schmidt Michelle , Lambert Sophie I. , Schauwinhold Michael T. , Klasen Martin , Sopka Saša 
Published: June 2023

Introduction
Practical skills training is an essential part of medical education. An important example is the training of Basic Life Support (BLS) skills, which are key to improve patient outcomes in life-threatening situations. However, despite practical training, BLS performance is often sub-optimal even among healthcare professionals and medical students. Finding more effective training methods is therefore of high importance. A promising method to enhance learning outcomes is reflective practice. The goal of the present study was to evaluate whether a short reflective practice intervention following standard BLS training (Peyton’s 4-step approach) improves BLS training outcomes, reflected in higher BLS performance and higher self-confidence to perform BLS.

Method
287 first-year medical students were randomly assigned to one of two BLS training conditions: 1) standard BLS training (ST), 2) ST followed by a 15-minute reflective practice exercise. Outcome parameters included objective BLS performance data assessed by a resuscitation manikin, and students’ self-reported confidence in their BLS skills. Outcomes were assessed directly after the training (T0) and re-assessed one week later (T1). A two-way mixed model analysis of variance (ANOVA) was conducted to examine the effect of the intervention on BLS performance and self-reported confidence. Significance was determined by two-sided 95% confidence intervals.

Results
The intervention group performed significantly more effective compressions at T1 and began significantly faster with performing their first chest compression at T0 and T1, in comparison to the control group. No significant differences between study groups regarding their self-reported confidence to perform BLS were observed.

Conclusion
This research shows that standard BLS training accompanied with a simple, cost-effective reflective practice exercise can improve learners’ BLS skill acquisition and retention. This shows that reflective practice has the potential to enhance practical skills training in medicine; yet, more empirical studies are needed to examine its broader applicability.
Guidelines, position statements, and advisories for the primary prevention of type 2 diabetes, hypertension, and cardiovascular disease in rural populations: A systematic review protocol
Authors: Tabatabaei Yeganeh Hanieh Sadat , Prokop Larry J. , Kiliaki Shangwe A. , Gnanapandithan Karthik , Yousufuddin Mohammed , Vella Adrian , Montori Victor M. , Dugani Sagar B. 
Published: June 2023

Introduction
Globally, noncommunicable diseases (NCDs), which include type 2 diabetes (T2D), hypertension, and cardiovascular disease (CVD), are associated with a high burden of morbidity and mortality. Health disparities exacerbate the burden of NCDs. Notably, rural, compared with urban, populations face greater disparities in access to preventive care, management, and treatment of NCDs. However, there is sparse information and no known literature synthesis on the inclusion of rural populations in documents (i.e., guidelines, position statements, and advisories) pertaining to the prevention of T2D, hypertension, and CVD. To address this gap, we are conducting a systematic review to assess the inclusion of rural populations in documents on the primary prevention of T2D, hypertension, and CVD.

Methods and analysis
This protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched 19 databases including EMBASE, MEDLINE, and Scopus, from January 2017 through October 2022, on the primary prevention of T2D, hypertension, and CVD. We conducted separate Google® searches for each of the 216 World Bank economies. For primary screening, titles and/or abstracts were screened independently by two authors (databases) or one author (Google®). Documents meeting selection criteria will undergo full-text review (secondary screening) using predetermined criteria, and data extraction using a standardized form. The definition of rurality varies, and we will report the description provided in each document. We will also describe the social determinants of health (based on the World Health Organization) that may be associated with rurality.

Ethics and dissemination
To our knowledge, this will be the first systematic review on the inclusion of rurality in documents on the primary prevention of T2D, hypertension, and CVD. Ethics approval is not required since we are not using patient-level data. Patients are not involved in the study design or analysis. We will present the results at conferences and in peer-reviewed publication(s).

Trial registration
PROSPERO Registration Number: CRD42022369815.
Deutsche Fachsprache der Architektur und des Bauwesens: Struktur und Semantik
Authors: Kiyko Svitlana , Rubana Yevheniia 
Published: June 2023

Abstract
The article deals with the study of structural and semantic features of the German professional language of architecture and construction. The study is based on the main principles of structural-semantic linguistic paradigm and represents the modeling of terminology in the form of a thesaurus with its multilevel classification structure. Achieving the main goal involves the selection of various structural types of terms and phrases, the analysis of key terms and their semantic fields and the study of possible logical-semantic relations in the proposed German professional language. The study was conducted in four stages. The first stage included an explanation of the main approaches to the study of both terminological systems of professional languages and individual terms. The second stage consisted in the analysis of logical-conceptual relations between terms, such as hypero-hyponymy, subcontracting as well as relations concerning the localization of the object, its purpose, etc. At this stage, terminology is considered as a thesaurus, taking into account the specifics of the organization of the studied branch of knowledge and the lexical-semantic field of the key terms of architecture and construction. The third stage was based on the structural and morphological analysis of the terms and included a description of structural models of terms. The last stage concerned the formulation of the conclusions of our study.
Mechanisms of Dominance: Understanding 30 Years in Power of Montenegro’s Democratic Party of Socialists
Authors: Laštro Claudia , Bieber Florian , Marović Jovana 
Published: June 2023

Abstract
This article analyses the mechanisms that contributed to the 30-year predominance of the Democratic Party of Socialists (DPS) in Montenegro. The authors pay particular attention to the DPS’ programmatic flexibility, use of co-optation, repression and control, as well as clientelism, examining their role in shaping state–society relations and party competition over time. In doing so, the article also seeks to explain the DPS’ setback in the 2020 elections and the ongoing transition from a dominant party system towards a more competitive multiparty system.
A Supporter in Vienna: Simon Wiesenthal and the War in Bosnia
Authors: Karčić Hamza 
Published: June 2023

Abstract
The author gives an inventory of Simon Wiesenthal’s advocacy for Bosnia during the 1992–1995 war. Though Wiesenthal played an active role in speaking up for Bosnia, his activism has been largely neglected in the existing literature. Based on primary sources at the Simon Wiesenthal Archive in Vienna, this article pieces together the story of how the famed Nazi hunter supported Bosnia-Herzegovina. Wiesenthal acted by speaking up about the atrocities in Bosnia, writing letters to influential decision-makers, and keeping Bosnia on the agenda. He supported a greater and more assertive American involvement to end the war and was a strong advocate of a UN war crimes tribunal, which materialized as the International Criminal Tribunal for the former Yugoslavia (ICTY). By lending his voice and moral stature, Wiesenthal helped shape public opinion in favour of a more assertive international reaction to the war.
LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates
Authors: Guo Qiannan , Li Yihui , Zhang Yunmei , Shen Liping , Lin Huayue , Chen Jianing , Song Erwei , Luo Man‐Li 
Published: June 2023

AbstractThe E3 ligase MDM2 promotes tumor growth and progression by inducing ubiquitin‐mediated degradation of P53 and other tumor‐suppressing proteins. Here, we identified an MDM2‐interacting lncRNA NRON, which promotes tumor formation by suppressing both P53‐dependent and independent pathways. NRON binds to MDM2 and MDMX (MDM4) via two different stem‐loops, respectively, and induces their heterogenous dimerization, thereby enhancing the E3 ligase activity of MDM2 toward its tumor‐suppressing substrates, including P53, RB1, and NFAT1. NRON knockdown dramatically inhibits tumor cell growth in vitro and in vivo. More importantly, NRON overexpression promotes oncogenic transformation by inducing anchorage‐independent growth in vitro and facilitating tumor formation in immunocompromised mice. Clinically, NRON expression is significantly associated with poor clinical outcome in breast cancer patients. Together, our data uncover a pivotal role of lncRNA that induces malignant transformation of epithelial cells by inhibiting multiple tumor suppressor proteins.
Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV‐1 pathogenesis
Authors: Wang Yetao , Lifshitz Lawrence , Silverstein Noah J , Mintzer Esther , Luk Kevin , StLouis Pamela , Brehm Michael A , Wolfe Scot A , Deeks Steven G , Luban Jeremy 
Published: June 2023

AbstractInnate lymphoid cells (ILCs) are a diverse population of cells that include NK cells and contribute to tissue homeostasis and repair, inflammation, and provide protection from infection. The interplay between human blood ILCs, as well as their responses to HIV‐1 infection, remains poorly understood. This study used transcriptional and chromatin profiling to explore these questions. Transcriptional profiling and flow cytometry analysis support that there are four main ILC subsets found in human blood. Unlike in mice, human NK cells expressed the tissue repair protein amphiregulin (AREG). AREG production was induced by TCF7/WNT, IL‐2, and IL‐15, and inhibited by TGFB1, a cytokine increased in people living with HIV‐1. In HIV‐1 infection, the percentage of AREG+ NK cells correlated positively with the numbers of ILCs and CD4+ T cells but negatively with the concentration of inflammatory cytokine IL‐6. NK‐cell knockout of the TGFB1‐stimulated WNT antagonist RUNX3 increased AREG production. Antiviral gene expression was increased in all ILC subsets from HIV‐1 viremic people, and anti‐inflammatory gene MYDGF was increased in an NK‐cell subset from HIV‐1‐infected people whose viral load was undetectable in the absence of antiretroviral therapy. The percentage of defective NK cells in people living with HIV‐1 correlated inversely with ILC percentage and CD4+ T‐cell counts. CD4+ T cells and their production of IL‐2 prevented the loss of NK‐cell function by activating mTOR. These studies clarify how ILC subsets are interrelated and provide insight into how HIV‐1 infection disrupts NK cells, including an uncharacterized homeostatic function in NK cells.
The epitaxial iron-yttrium garnet films with homogeneous properties and narrow FMR line width
Authors: Yushchuk S.I. , Yur`ev S.A. , Moklyak V.V. 
Published: June 2023

The growth of iron-yttrium garnet Y3Fe5O12 (YIG) films with of 1...15 μm thicknesses on single-crystal substrates of gallium-gadolinium garnet Gd3Ga5O12 (GGG) was carried out using the method of liquid phase epitaxy (LPE). The influence of the composition and mass of the charge, the temperature regimes, the rates of movement and the substrate rotation on the films parameters were studied. The layered structure caused by the heterogeneity of the chemical composition in the film thickness was determined and studied The dependence of the degree impurity of Pb2+ and Pt4+ ions in YIG films and their influence on the ferromagnetic resonance (FMR) line width ∆H on the films growth conditions was investigated. It’s shown that in order to obtain by the LPE method the series of defect-free films with low magnetic losses and reproducible parameters, it’s necessary to use melt-solutions of large mass (6...12 kg) and apply their additional mixing during the growth process.
Mesopotamian archaeology and travel literature: shifting relationships
Authors: Ooghe B. 
Published: June 2023

El estudio en la última década de las relaciones entre viajes, literatura de viajes y la arqueología del Próximo Oriente antiguo ha pasado de ser un tema eludible de la arqueología a tener su propio campo de investigación. Aun así, mucho de lo que se ha publicado hasta el momento se ha centrado en el siglo XIX, en cuestiones de yacimientos concretos o en personajes destacados. La investigación sobre los primeros exploradores, el desarrollo general de intereses académicos en la región y el potencial uso práctico de los escritos de viajes todavía tienen que integrarse plenamente en la disciplina arqueológica del Próximo Oriente antiguo. Con la moda actual de los estudios sobre viajes y las recientes publicaciones de algunas visiones generales que ofrecen nuevos elementos significativos parece que ha llegado el momento de ver cómo se ha desarrollado la relación existente entre la literatura de viajes y la arqueología del Próximo Oriente -en concreto de (la baja) Mesopotamia-. Este artículo defiende que el desarrollo de la arqueología mesopotámica como una disciplina aparte y una percepción concreta de su historia han introducido durante los siglos XIX y XX una cuña entre el arqueólogo y el viajero, así como entre la investigación arqueológica y la literatura de viajes. Como visión general del cambio en las relaciones entre ambos, este artículo aboga por una mayor integración de los estudios sobre viajes en el campo de la arqueología.Palabras clave: Arqueología, viaje, Mesopotamia, literatura, historia disciplinaria. AbstractStudying the links between travel, travel literature and the archaeology of the Near East has, over the course of the past decade, slowly developed from a side-step of archaeology into a more ‘proper’ field of enquiry. However, much of what has been published so far has remained focused on the nineteenth century, on site-specific issues or on highlighted individuals. Research into the early explorers, the broad developments of academic interests in the region and the potential practical use of travel writing have yet to become fully integrated into the Near Eastern archaeological discipline. With the present vogue of travel studies and the recent publication of several overviews offering significant new insights, the time seems at hand for an examination of how the relationships between travel literature and Near Eastern –specifically (lower) Mesopotamian– archaeology have developed over time. This paper argues that the development of Mesopotamian archaeology as a distinct discipline and a specific perception of its history have during the nineteenth and twentieth centuries drawn a wedge between the archaeologist and the traveler, as well as between archaeological research and travel literature. As a general overview of changing relationships between the two, the paper pleads for a more thorough integration of travel studies into the field of archaeology.Keywords: Archaeology, travel, Mesopotamia, literature, disciplinary history.
Edgar Poe y el próximo oriente de la antigüedad
Authors: Fernández Palacios F. 
Published: June 2023

El artículo analiza la aparición del Próximo Oriente de la Antigüedad en la obra de Edgar Poe (1809-1849), especialmente en 12 de sus escritos. Con ello se extraen conclusiones acerca de las funciones del Antiguo Próximo Oriente en Poe y también acerca de la recepción en la Norteamérica de la primera mitad del siglo XIX de noticias sobre exploraciones e investigaciones en aquellas tierras.Palabras clave: Literatura, Historia, Poe, Antiguo Próximo Oriente, exploraciones. AbstractThe article analyzes the appearance of the Ancient Near East in the works of Edgar Poe (1809-1849), especially in 12 of his writings. Some conclusions are reached on the purposes of the Ancient Near East in Poe and on the reception in the North America of the 1st half of the 19th century of news about exploration and research in those lands.Keywords: Literature, History, Poe, Ancient Near East, explorations.
La aventura de Paul Nadar en Turkestán: Sobre fotografías y el redescubrimiento de Asia Central
Authors: Fernández Negro Javier 
Published: June 2023

A finales del siglo XIX las líneas fronterizas se quebraban, lo lejano y exótico comenzaba a antojarse próximo. Uno de los que acercaron a la sociedad occidental el espacio geográfico y el marco cultural de la Ruta de la Seda fue Paul Nadar a través de sus fotografías. Hijo del célebre Félix Nadar, el fotógrafo siguió la estela paterna en aras del avance de una nueva disciplina, cuyas posibilidades parecían no tener límites. Entre los meses de agosto y noviembre de 1890, P. Nadar recorrió el país turkmeno gracias a la recién nacida línea ferroviaria transcaspiana. De aquel viaje nos dejó aproximadamente 1.200 instantáneas en las que podemos ver la vida y costumbres de los pueblos de Asia Central, así como las ruinas de Samarcanda y Merv, entre otras.Palabras clave: Paul Nadar, fotografía, viaje a Asia Central, arqueología de Asia Central, redescubrimiento de Asia Central Abstract: In the end of the XIXth century the opposite lines were broken, the distant and exotic began to be closer. One of the main characters who closed to the western society the geography and culture of the Silk Route through his pictures was Paul Nadar. The son of the famous Felix Nadar followed his trail, advancing in one new discipline, the photography, whose possibilities had not limits. Between August and November of 1890, Nadar travelled around Turkmen thanks to the new trascaspasiana railway. In this journey Nadar let us approximately 1200 pictures in which we can see the life and customs of the villages from Asia Central, and the ruins of Samarkand and Merv, among others.Keywords: Paul Nadar, photography, Journey to Central Asia, archeology to Central Asia, rediscovery of the Central Asia.
Evolución de la presencia guti en Mesopotamia y su papel en el colapso del Imperio acadio
Authors: Torres Elena 
Published: June 2023

La presencia de población guti en Mesopotamia se ha interpretado tradicionalmente como producto de la irrupción brusca de este pueblo de los Zagros en la Mesopotamia de finales del Imperio acadio. Los testimonios de que disponemos son escasos y oscuros, indirectos en su mayoría. Nos permiten vislumbrar sin embargo que Gutium está presente en la zona desde mucho antes, y su relación con la cultura mesopotámica adopta diferentes roles en distintos momentos: como frontera oriental en las vías de comercio a larga distancia en época sumeria, como tributarios del Imperio sargónida y finalmente como el grupo de población que aprovecha una coyuntura de vacío de poder al final del período acadio para hacerse con el control efímero de una pequeña parte del territorio que antes había conformado el gran Imperio acadio.Palabras clave: Gutium, guti, Imperio acadio, Zagros, pueblos tributarios, comercio, Lugalannemundu, Adab, Sargón, Naram-Sîn, ŠarkaliXarri, Elulu, Dudu, Šu-durul, anarquía. AbstractThe presence of Gutian population in Mesopotamia has been traditionally interpreted as a consequence of the irruption of this people from the Zagros into the Mesopotamia of the late Akkadian empire. The statements we have are scant and dubious, mainly indirect. They let us nevertheless discern that Gutium is present on the zone from much before, and its relationships with Mesopotamian culture adopt different rolls in different moments: as an eastern border in the long distance merchandising routes at Sumerian time, as tributary land of the Sargonid empire, and finally as a group of population that takes advantage of the power vacuum at the end of the Akkadian period to obtain an ephemeral control of a small part of the territory that had once constituted the great Akkadian empire.Keywords: Gutium, Gutean, Akkadian empire, Zagros mountains, tributary peoples, Lugalannemundu, Adab, Sargon, Naram-Sîn, ŠarkaliXarri, Elulu, Dudu, Šu-durul, anarchy.