bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implant surface physicochemistry affects keratinocyte hemidesmosome formation
Authors: Raptopoulos Michail , Fischer Nicholas G. , Aparicio Conrado 
Published: January 2023

AbstractPrevious studies have shown hydrophilic/hydrophobic implant surfaces stimulate/hinder osseointegration. An analogous concept was applied here using common biological functional groups on a model surface to promote oral keratinocytes (OKs) proliferation and hemidesmosomes (HD) to extend implant lifespans through increased soft tissue attachment. However, it is unclear what physicochemistry stimulates HDs. Thus, common biological functional groups (NH2, OH, and CH3) were functionalized on glass using silanization. Non‐functionalized plasma‐cleaned glass and H silanization were controls. Surface modifications were confirmed with X‐ray photoelectron spectroscopy and water contact angle. The amount of bovine serum albumin (BSA) and fibrinogen, and BSA thickness, were assessed to understand how adsorbed protein properties were influenced by physicochemistry and may influence HDs. OKs proliferation was measured, and HDs were quantified with immunofluorescence for collagen XVII and integrin β4. Plasma‐cleaned surfaces were the most hydrophilic group overall, while CH3 was the most hydrophobic and OH was the most hydrophilic among functionalized groups. Modification with the OH chemical group showed the highest OKs proliferation and HD expression. The OKs response on OH surfaces appeared to not correlate to the amount or thickness of adsorbed model proteins. These results reveal relevant surface physicochemical features to favor HDs and improve implant soft tissue attachment.
Open pilot trial of an interactive digital application for campus sexual violence prevention
Authors: Orchowski Lindsay M. , Zinzow Heidi , Thompson Martie , Wood Sharon 
Published: January 2023

AbstractDigital applications, or “serious games” for health address learning goals in a cognitively active, interactive manner, with the potential for widespread dissemination. This study used a mixed methods approach to develop and conduct a formative evaluation of a digital application for sexual assault prevention. Make a change is a digital application that uses the principles of games for health to foster learning, engagement, and skill‐building around risk and protective factors for sexual victimization, sexual aggression, and bystander intervention. The digital application includes four narrative chapters, six embedded activities, as well as a user‐derived change plan in which individuals establish goals for behavior change following program completion. This multisite study at a 2‐ and a 4‐year college utilized student interviews (n = 14), stakeholder interviews (n = 10), and focus groups with students (n = 40) to inform intervention development. A total of 41 college students then participated in an open trial and completed self‐report surveys (pre, post, and 1‐month follow‐up) to evaluate the feasibility, acceptability, utility, and preliminary outcomes. Most of the sample reported enjoyment, usefulness, and perceived competence after completing the application. Data evidenced a trend to reduce the frequency of heavy drinking, and perceptions of social norms evidenced change over time. Findings support the feasibility and effectiveness of this novel format for the delivery of sexual assault prevention programming.
The impact of family income and parental factors on children's resilience and mental well‐being
Authors: Bruno William , Dehnel Rebecca , Al‐Delaimy Wael 
Published: January 2023

AbstractAlthough there is robust evidence on the intergenerational transmission of trauma‐related distress, much less is known about the relation of family income and parental resilience on the resilience and mental well‐being of traumatized children. We aimed to determine the association between parental resilience and perceived financial stability, and the resilience and depression of their children among Syrian refugees in Jordan. We carried out a survey of 363 parent−child dyads from a refugee clinic in Northern Jordan. Measures of resilience, trauma, symptoms of mental illnesses, and demographics were reported by the mother and child. We evaluated the associations between parental resilience and their children's mental health. Resilience was highest among parents who reported that their income met their financial needs, (65.77 [standard deviation (SD) 15.96]), and lower for those who reported less income or who stated that their income met their needs only fairly well (62.77 [SD 17.56]). Resilience was lowest for those who reported that that income met their needs poorly (48.02 [SD 23.24]). Parent resilience was positively correlated with child resilience (β = 0.076 [95% confidence interval 0.035−0.12], p < 0.001). Depression and resilience of parents were most closely correlated with the depression and resilience scores of their children, among parents who reported the highest financial stability. Income plays a modifying role in the parent−child resilience and depression associations, with this association being least pronounced within those families who were financially less secure. These findings can help develop interventions to target parental transgenerational impacts according to income status.
Adding a genetic counseling assistant improves efficiency of hereditary cancer genetic counseling without impacting patient experience
Authors: Cohen Stephanie A. , Nixon Dawn M. , Lichtenberg Emily 
Published: January 2023

AbstractImproving efficiency of genetic counseling can allow genetic counselors to see more patients, increasing access to this valuable service. However, the patient experience should be carefully considered as changes are made, so that quality is not sacrificed. The primary outcome of this study was time in session with a board‐certified genetic counselor at baseline (T0), after the addition of a genetic counseling assistant (GCA) (T1). The secondary outcome was the patient experience, which was collected from an electronic survey sent three days after the genetic counseling session. A total of 689 appointments were evaluated over 12 months; 291 in T0 by two genetic counselors (Jan–June 2019), 398 in T1 by two genetic counselors (August 2019–Jan 2020). The overall genetic counseling median appointment time decreased by 10 min in T1 (p < 0.001), and the median amount of time spent on post‐session activities by the two genetic counselors decreased by 15 min (p < 0.001). There was an increase in the average number of patients seen per FTE per month from 24.3 in T0 to 33.2 in T1. There was no difference in overall patient experience from T0 to T1 (p = 0.3). There was high patient satisfaction, including with the amount of time spent in a session during both time periods (p = 0.63). This study found decreased appointment time with the addition of a GCA in a single clinic without impacting patient experience.
Curvature on graphs via equilibrium measures
Authors: Steinerberger Stefan 
Published: January 2023

AbstractWe introduce a notion of curvature on finite, combinatorial graphs. It can be easily computed by solving a linear system of equations. We show that graphs with curvature bounded below by have diameter bounded by (a Bonnet–Myers theorem), that implies that has constant curvature (a Cheng theorem) and that there is a spectral gap (a Lichnerowicz theorem). It is computed for several families of graphs and often coincides with Ollivier curvature or Lin–Lu–Yau curvature. The von Neumann Minimax theorem features prominently in the proofs.
An extreme cold event over East Asia during early January 2021 and its links to the deformation of stratospheric polar vortex during sudden stratospheric warming
Authors: Liu Meichen , Hu Dingzhu , Guan Zhaoyong 
Published: January 2023

AbstractIn early winter of 2020/2021, East Asia experienced two extreme cold events (ECEs), during which a number of national stations in China reached the standard of ECE or broke records. The underlying dynamical processes of these record‐breaking ECEs are investigated using Modern‐Era Retrospective Analysis for Research and Applications version 2 reanalysis dataset. Results show that these ECEs were closely related to the sudden stratospheric warming (SSW) event. During 29 December, 2020–1 January, 2021 (the first ECE), the tropospheric polar vortex migrated to mid‐latitude East Asia and more planetary wave propagated into the stratosphere. Then, the stratospheric polar vortex weakened and extended to mid‐latitude East Asia from 2 January. And, a SSW event occurred on 5 January. The easterly zonal wind accompanied by the deformation of stratospheric polar vortex over East Asia tended to strengthen the East Asian trough via reflecting the planetary wave from the stratosphere to troposphere. Simultaneously, the southward shifting of the Ural ridge resulted in the extremely strong East Asian trough migrating southward, which led to the strengthening and southward migration of near‐surface anticyclonic circulation. Then, another ECE broke out during 6–7 January (the second ECE). Therefore, the ECE in early January was jointly caused by the combined effects of deformation of stratospheric polar vortex during SSW event and the southward shifting of Ural ridge. Further analysis suggested that about 8% of the total ECEs during 1980/1981–2019/2020 were related to the extension of stratospheric polar vortex to East Asia.
Insights into peptide profiling of sturgeon myofibrillar proteins with low temperature vacuum heating
Authors: Jiang Dan‐dan , Shen Shi‐ke , Yu Wen‐tao , Bu Qian‐yun , Ding Zhi‐wen , Fu Jing‐jing 
Published: January 2023

AbstractBACKGROUNDProtein oxidation during food processing causes changes in the balance of protein–molecular interactions and protein–water interactions, ultimately leading to protein denaturation, which results in the loss of a range of functional properties. Therefore, how to control the oxidative modification of proteins during processing has been the focus of research.RESULTSIn the present study, the intrinsic fluorescence value of the myofibrillar proteins (MP) decreased and the surface hydrophobicity value increased, indicating that the heat treatment caused a significant change in the conformation of the MP. With an increase in heating temperature, protein carbonyl content increased, total sulfhydryl content decreased, and protein secondary structure changed from α‐helix to β‐sheet, indicating that protein oxidation and aggregation occurred. Sodium dodecyl sulfate‐polyacrylamide gel electrophoresis revealed that heat treatment can lead to the degradation of proteins, especially myosin heavy chain, although actin had a certain thermal stability. In total, 733 proteins were identified by proteomics, and the protein oxidation caused by low temperature vacuum heating (LTVH) was determined to be mild oxidation dominated by malondialdehyde and 4‐hydroxynonenal by oxidation site division.CONCLUSIONThe present study has revealed the effect of LTVH treatment on the protein oxidation modification behavior of sturgeon meat, and explored the effect mechanism of LTVH treatment on the processing quality of sturgeon meat from the perspective of protein oxidation. The results may provide a theoretical basis for the precise processing of aquatic products. © 2023 Society of Chemical Industry.
Sarcopenia and frailty as predictors of surgical morbidity and oncologic outcomes in retroperitoneal sarcoma
Authors: Nasirishargh Aida , Grova Monica , Bateni Cyrus P. , Judge Sean J. , Nuno Miriam A. , Basmaci Ugur Nur , Canter Robert J. , Bateni Sarah B. 
Published: January 2023

AbstractBackgroundRetroperitoneal sarcomas (RPS) are rare tumors for which surgical resection is the principal treatment. There is no established model to predict perioperative risks for RPS. We evaluated the association between preoperative sarcopenia, frailty, and hypoalbuminemia with surgical and oncological outcomes.MethodsWe performed a prospective cohort analysis of 65 RPS patients who underwent surgical resection. Sarcopenia was defined as Total Psoas Area Index ≤ 1st quintile by sex. Frailty was estimated using the modified frailty index (mFI). Logistic regression models were used to assess predictors of 30‐day postoperative morbidity. The Kaplan–Meier method with log‐rank test was utilized to assess factors associated with overall (OS) and recurrence‐free survival (RFS).ResultSarcopenia was associated with worse OS with a median of 54 compared with 158 months (p = 0.04), but no differences in RFS (p > 0.05). Hypoalbuminemia was associated with worse OS with a median of 72 compared with 158 months (p < 0.01). MFI scores were not associated with OS or RFS (p > 0.05). Sarcopenia, mFI, and hypoalbuminemia were not associated with postoperative morbidity (p > 0.05).ConclusionThis study suggests that sarcopenia may be utilized as a measure of overall fitness, rather than a cancer‐specific risk, and the mFI is a poor predictive measure of outcomes in RPS.
Exploration of the effects of chloride ions on the analysis of polar compounds at low concentrations by hydrophilic interaction liquid chromatography coupled to a charged aerosol detector: Application to tromethamine
Authors: Toussaint Balthazar , Immame Hassane Beck Taslyne , Surget Estelle , Boudy Vincent , Jaccoulet Emmanuel 
Published: January 2023

In this study, we discuss the origin of the slightly increased response of the charged aerosol detector when low‐concentration polar drugs formulated with sodium chloride are analyzed by hydrophilic interaction liquid chromatography coupled to the charged aerosol detector. In the case of tromethamine mixed with saline solutions, we investigated several levels including the mobile phase, sample matrix, and detection. We show that the analysis of the rich‐salted sample results in both interactions with the mobile phase modifiers and the stationary phase during the run time. With 150 mM NaCl as a compounding solution, a slight increase in the tromethamine peak area was observed (<5.5%). Our study suggests that chloride ions in excess sequentially interact firstly with the counterions from the organic modifiers and secondly with the analyte via the stationary phase and the contribution of hydrophilic interaction liquid chromatography retention mechanisms. Because of these effects, the hydrophilic interaction liquid chromatography‐charged aerosol detector analysis of drugs in saline solutions requires particular attention, and a correction factor for quantitative purposes that accounts for formulation ions remains appropriate.
Multi‐scale effects of land cover, weather, and fire on Columbian sharp‐tailed grouse
Authors: Stevens Bryan S. , Conway Courtney J. , Knetter Jeffrey M. , Roberts Shane B. , Donnelly Patrick 
Published: January 2023

AbstractColumbian sharp‐tailed grouse (Tympanuchus phasianellus columbianus) are endemic to grassland and shrub‐steppe ecosystems of western North America, yet their distribution has contracted to <10% of their historical range. Primary threats to Columbian sharp‐tailed grouse include loss of native habitat and conversion to agriculture, reductions in habitat once provided by the Conservation Reserve Program (CRP), wildfire, and drought conditions, yet population‐level consequences of these threats and their spatio‐temporal scales of effect are poorly understood. We evaluated multi‐scale effects of land cover, weather, and fire histories on patterns of abundance and productivity for Columbian sharp‐tailed grouse populations during 1995–2020 in Idaho, USA, using mixed‐effects generalized regression and remotely sensed data. We demonstrated negative effects of fire, tree encroachment, and bare ground, positive effects of spring and summer precipitation and cover of shrubs and perennial forbs and grasses, and positive effects of CRP on grouse abundance that changed in magnitude with cover of perennials and shrubs near leks (i.e., strongest effects when average cover of shrubs and perennial forbs and grasses were less abundant). We also demonstrated per capita recruitment of Columbian sharp‐tailed grouse is positively associated with late‐summer greenness. Our results show that several suspected threats have measurable, population‐level impacts to Columbian sharp‐tailed grouse within Idaho. Moreover, our results suggest ongoing changes occurring within the core range of Columbian sharp‐tailed grouse, including loss of CRP cover to tilled agriculture and changes to wildfire and precipitation dynamics are likely to have negative effects on populations.
Genetics for seed traits and Mungbean yellow mosaic India virus reaction in urdbean (Vigna mungo L. Hepper)
Authors: Sen Gupta Debjyoti , Kumar Jitendra , Lamichaney Amrit , Parihar Ashok Kumar , Das Sankar Prasad , Kumar Anurag , Katiyar Pardip Kumar , Gupta Sanjeev 
Published: January 2023

AbstractUrdbean or blackgram is one of the important multi‐season pulse crops grown in India. Improved seed quality and resistance to Mungbean yellow mosaic India virus (MYMIV) are the important objectives of the urdbean breeding program. For this, knowledge of inheritance for seed quality traits and MYMIV resistance is essentially required. Therefore, an attempt has been made to understand the inheritance of seed traits like seed luster, seed coat color, mosaic on seed surface, and MYMIV reaction using intra‐ and inter‐specific bi‐parental populations. The inheritance results revealed that in DPU88‐31 × LBG‐685 population, the shining seed registered dominance over the dull trait, while the green seed coat color exhibited dominance over the brown seed coat color. However, the inter‐specific F2 population derived from IPU11‐02 × Pant M 6 deviated significantly from Mendelian ratios and supported severe segregation distortion for seed traits, while the mosaic on seed coat or mottling character studied in interspecific population demonstrated a dominant digenic inheritance pattern. In five inter‐ and intra‐specific F2 populations, MYMIV resistance demonstrated monogenic dominant inheritance, which was also validated in F3 generations. Furthermore, linkage analysis exhibited an association between seed luster and seed coat color, while no association was noticed between seed traits and MYMIV resistance. The normality tests revealed that seed width and 100 seeds weight were controlled by a few major genes, while other quantitative traits were governed by many genes with small additive effects. The skewness suggested that complementary gene interactions were present among genes controlling 100 seed weight in the intra‐specific cross, while duplicate gene interactions were involved in the inter‐specific cross. The identified monogenic traits and linked morphological marker after further enrichment of the linkage group could be used as an important tool in the regular breeding program.
Existence of uncertainty minimizers for the continuous wavelet transform
Authors: Halvdansson Simon , Olsen Jan‐Fredrik , Sochen Nir , Levie Ron 
Published: January 2023

AbstractContinuous wavelet design is the endeavor to construct mother wavelets with desirable properties for the continuous wavelet transform (CWT). One class of methods for choosing a mother wavelet involves minimizing a functional, called the wavelet uncertainty functional. Recently, two new wavelet uncertainty functionals were derived from theoretical foundations. In both approaches, the uncertainty of a mother wavelet describes its concentration, or accuracy, as a time‐scale probe. While an uncertainty minimizing mother wavelet can be proven to have desirable localization properties, the existence of such a minimizer was never studied. In this paper, we prove the existence of minimizers for the two uncertainty functionals.
Semigroup wellposedness and asymptotic stability of a compressible Oseen–structure interaction via a pointwise resolvent criterion
Authors: Geredeli Pelin G. 
Published: January 2023

AbstractIn this study, we consider the Oseen structure of the linearization of a compressible fluid–structure interaction (FSI) system for which the interaction interface is under the effect of material derivative term. The flow linearization is taken with respect to an arbitrary, variable ambient vector field. This process produces extra “convective derivative” and “material derivative” terms, which render the coupled system highly nondissipative. We show first a new well‐posedness result for the full incorporation of both Oseen terms, which provides a uniformly bounded semigroup via dissipativity and perturbation arguments. In addition, we analyze the long time dynamics in the sense of asymptotic (strong) stability in an invariant subspace (one‐dimensional less) of the entire state space, where the continuous semigroup is uniformly bounded. For this, we appeal to the pointwise resolvent condition introduced in Chill and Tomilov [Stability of operator semigroups: ideas and results, perspectives in operator theory Banach center publications, 75 (2007), Institute of Mathematics Polish Academy of Sciences, Warszawa, 71–109], which avoids an immensely technical and challenging spectral analysis and provides a short and relatively easy‐to‐follow proof.
A comparison between 2D and 3D descriptors in QSAR modeling based on bio‐active conformations
Authors: Bahia Malkeet Singh , Kaspi Omer , Touitou Meir , Binayev Idan , Dhail Seema , Spiegel Jacob , Khazanov Netaly , Yosipof Abraham , Senderowitz Hanoch 
Published: January 2023

AbstractQSAR models are widely and successfully used in many research areas. The success of such models highly depends on molecular descriptors typically classified as 1D, 2D, 3D, or 4D. While 3D information is likely important, e. g., for modeling ligand‐protein binding, previous comparisons between the performances of 2D and 3D descriptors were inconclusive. Yet in such comparisons the modeled ligands were not necessarily represented by their bioactive conformations. With this in mind, we mined the PDB for sets of protein‐ligand complexes sharing the same protein for which uniform activity data were reported. The results, totaling 461 structures spread across six series were compiled into a carefully curated, first of its kind dataset in which each ligand is represented by its bioactive conformation. Next, each set was characterized by 2D, 3D and 2D + 3D descriptors and modeled using three machine learning algorithms, namely,k‐Nearest Neighbors, Random Forest and Lasso Regression. Models’ performances were evaluated on external test sets derived from the parent datasets either randomly or in a rational manner. We found that many more significant models were obtained when combining 2D and 3D descriptors. We attribute these improvements to the ability of 2D and 3D descriptors to code for different, yet complementary molecular properties.