bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Probiotics on Oxidized LDL Levels: A Systematic
Review and Meta-Analysis of Clinical Trials
Authors: Kiani Zahra , Rouhani Mohammad Hossein , mahdavi Atena , Askari Gholamreza , Jamialahmadi Tannaz , Bagherniya Mohammad , Sahebkar Amirhossein 
Published: August 2023

Background:
It has been widely reported that the use of probiotics has beneficial effects on the prevention and treatment of a wide range of human diseases. Previous clinical trials have investigated the effect of probiotics on oxLDL, but the results are controversial.

Objective:
This study aimed to conduct a systematic review and meta-analysis of clinical trials to assess the effect of probiotic consumption on oxLDL levels.

Method:
A comprehensive search was conducted in PubMed, ISI Web of Science, and Scopus using the appropriate search strategy. After the screening, seven studies comparing the effects of probiotic consumption with the control were included in the analysis. A random-effects analysis was used to estimate the overall effect size.

Results:
Probiotic supplementation significantly reduced oxLDL (Hedge's: -1.18; 95% CI:-1.85, -0.52) compared to the control group. Subgroup analysis showed that reduction was greater in the unhealthy group compared to healthy subjects (-2.05 vs. -0.84). The results also showed that probiotic supplementation reduced TC by -14.77 mg/dl (95% CI: -24.46, -5.08), LDL-C by -10.03 mg/dl (95% CI: -16.05, -4.001), LDL-C/HDL-C ratio by -0.37 (95% CI: -0.66, 0.07), and TG by -14.86 mg/dl (95% CI: -23.45, -6.28) but the effects on HDL-C and glucose were not significant.

Conclusion:
In this study, probiotic supplementation was found to improve oxLDL concentrations and have favorable effects on lipid profiles, but no significant positive effect on HDL-C and glucose was reported. However, the findings should be interpreted with caution due to the low number of included studies.
The HPA Axis as Target for Depression
Authors: Menke Andreas 
Published: August 2023

Abstract:
Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime prevalence
of 20% and, thus, is one of the most prevalent mental health disorders worldwide. Many studies
with a large number of patients support the notion that abnormalities of the hypothalamus-pituitaryadrenal
(HPA) axis are crucial for the development of MDD. Therefore, a number of strategies and
drugs have been investigated to target different components of the HPA axis: 1) corticotrophinreleasing
hormone (CRH) 1 receptor antagonists; 2) vasopressin V1B receptor antagonists, 3) glucocorticoid
receptor antagonists, and 4) FKBP5 antagonists. Until now, V1B receptor antagonists and GR
antagonists have provided the most promising results. Preclinical data also support antagonists of
FKBP5, which seem to be partly responsible for the effects exerted by ketamine. However, as HPA
axis alterations occur only in a subset of patients, specific treatment approaches that target only single
components of the HPA axis will be effective only in this subset of patients. Companion tests that
measure the function of the HPA axis and identify patients with an impaired HPA axis, such as the
dexamethasone-corticotrophin-releasing hormone (dex-CRH) test or the molecular dexamethasonesuppression
(mDST) test, may match the patient with an effective treatment to enable patient-tailored
treatments in terms of a precision medicine approach.
Interleukin-17: A Putative Novel Pharmacological Target for Pathological
Pain
Authors: Gao Shao-Jie , Liu Lin , Li Dan-Yang , Liu Dai-Qiang , Zhang Long-Qing , Wu Jia-Yi , Song Fan-He , Zhou Ya-Qun , Mei Wei 
Published: August 2023

Abstract:
Pathological pain imposes a huge burden on the economy and the lives of patients. At present,
drugs used for the treatment of pathological pain have only modest efficacy and are also plagued
by adverse effects and risk for misuse and abuse. Therefore, understanding the mechanisms of pathological
pain is essential for the development of novel analgesics. Several lines of evidence indicate that
interleukin-17 (IL-17) is upregulated in rodent models of pathological pain in the periphery and central
nervous system. Besides, the administration of IL-17 antibody alleviated pathological pain. Moreover,
IL-17 administration led to mechanical allodynia which was alleviated by the IL-17 antibody. In this
review, we summarized and discussed the therapeutic potential of targeting IL-17 for pathological
pain. The upregulation of IL-17 promoted the development of pathological pain by promoting neuroinflammation,
enhancing the excitability of dorsal root ganglion neurons, and promoting the communication
of glial cells and neurons in the spinal cord. In general, the existing research shows that IL-17 is
an attractive therapeutic target for pathologic pain, but the underlying mechanisms still need to be investigated.
Flavonoids in Astragali Radix Functions as Regulators of CDK2, VEGFA and MYC in Osteoporosis and Type 1 Diabetes Mellitus
Authors: Liu Zimeng , Zuo Xuemei , Cai Yisheng , Zuo Yuyang , Ma Keqiang , Wu Shuang , Qu Xiaochao , Chen Xiangding 
Published: August 2023

Background:
People with type 1 diabetes mellitus (T1DM) are significantly more likely to
have osteoporosis (OP). Astragali Radix is a Chinese herbal medicine containing various active ingredients,
and several clinical trials have been reported to use it to treat OP and T1DM, respectively.

Objective:
To evaluate the targets and potential mechanisms of Astragali Radix administration on OP and
T1DM.

Methods:
The targets of Astragali Radix were identified using the Traditional Chinese Medicine Systems
Pharmacology (TCMSP) database. The OP and T1DM datasets were downloaded from the Gene Expression
Omnibus (GEO) database. The weighted gene correlation network analysis (WGCNA) method was
used to identify the co-expression genes associated with OP and T1DM. In addition, the common gene
targets of OP and T1DM were screened using two public databases. Gene Ontology (GO) and Kyoto
Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using the R tool.
After the validation of key genes, molecular docking was performed to visualize small molecule-protein
interactions.

Results:
The compound target network mainly contained 17 compounds and 147 corresponding targets.
There were 561 GO items and 154 signaling pathways in KEGG, mainly including the AGE-RAGE signaling
pathway in diabetic complications and osteoclast differentiation. The results of molecular docking
showed that flavonoids were the top compound of Astragali Radix, which had a high affinity with CDK2,
VEGFA, and MYC.

Conclusion:
Flavonoids in Astragali Radix may regulate multiple signaling pathways through MYC,
CDK2, and VEGFA, which may play a therapeutic role in OP and T1DM.
Cocreation of Assistive Technologies for Patients With Long COVID: Qualitative Analysis of a Literature Review on the Challenges of Patient Involvement in Health and Nursing Sciences
Authors: Dalko Katharina , Kraft Bernhard , Jahn Patrick , Schildmann Jan , Hofstetter Sebastian 
Published: August 2023

Background
Digital assistive technologies have the potential to address the pressing need for adequate therapy options for patients with long COVID (also known as post–COVID-19 condition) by enabling the implementation of individual and independent rehabilitation programs. However, the involvement of the target patient group is necessary to develop digital devices that are closely aligned to the needs of this particular patient group.

Objective
Participatory design approaches, such as cocreation, may be a solution for achieving usability and user acceptance. However, there are currently no set methods for implementing cocreative development processes incorporating patients. This study addresses the following research questions: what are the tasks and challenges associated with the involvement of patient groups? What lessons can be learned regarding the adequate involvement of patients with long COVID?

Methods
First, a literature review based on a 3-stage snowball process was conducted to identify the tasks and challenges emerging in the context of the cocreation of digital assistive devices and services with patient groups. Second, a qualitative analysis was conducted in an attempt to extract relevant findings and criteria from the identified studies. Third, using the method of theory adaptation, this paper presents recommendations for the further development of the existing concepts of cocreation in relation to patients with long COVID.

Results
The challenges of an active involvement of patients in cocreative development in health care include hierarchical barriers and differences in the levels of specific knowledge between professionals and patients. In the case of long COVID, patients themselves are still inexperienced in dealing with their symptoms and are hardly organized into established groups. This amplifies general hurdles and leads to questions of group identity, power structure, and knowledge creation, which are not sufficiently addressed by the current methods of cocreation.

Conclusions
The adaptation of transdisciplinary methods to cocreative development approaches focusing on collaborative and inclusive communication can address the recurring challenges of actively integrating patients with long COVID into development processes.
Readiness for Change in the Implementation of a 3D Printing Initiative in a Catalan Tertiary Hospital Using the Normalization Process Theory: Survey Study
Authors: López Seguí Francesc , Cos Codina Joan , Ricou Ríos Laura , Martínez Segura María Isabel , Miró Mezquita Laura , Escrich Navarro Raquel , Davins Riu Meritxell , Estrada Cuxart Oriol , Anashkin Kachalin German , Moreno-Martínez Daniel 
Published: August 2023

Background
The high failure rate of innovation projects motivates us to understand the perceptions about resistances and barriers of the main stakeholders to improving success rates.

Objective
This study aims to analyze the readiness for change in the implementation of a 3D printing project in a Catalan tertiary hospital prior to its implementation.

Methods
We used a web-based, voluntary, and anonymous survey using the Normalization Measurement Development questionnaire (NoMAD) to gather views and perceptions from a selected group of health care professionals at Germans Trias i Pujol University Hospital.

Results
In this study, 58 professionals, including heads of service (n=30, 51%), doctors (n=18, 31%), nurses (n=7, 12%), and support staff (n=3, 5%), responded to the questionnaire. All groups saw the value of the project and were willing to enroll and support it. Respondents reported the highest scores (out of 5) in cognitive participation (mean 4.45, SD 0.04), coherence (mean 3.72, SD 0.13), and reflective monitoring (mean 3.80, SD 0.25). The weakest score was in collective action (mean 3.52, SD 0.12). There were no statistically significant differences in scores among professions in the survey.

Conclusions
The 3D printing project implementation should pay attention to preparing, defining, sharing, and supporting the operational work involved in its use and implementation. It should also understand, assess, and communicate the ways in which the new set of practices can affect the users and others around them. We suggest that health officers and politicians consider this experience as a solid ground toward the development of a more efficient health innovation system and as a catalyst for transformation.
Work-life balance di era new normal pada pekerja wanita
Authors: Milleniva Lintar Niendhya , Ingarianti Tri Muji , Syakarofath Nandy Agustin 
Published: August 2023

New normal has changed the way people live and work which has an impact on work and family life, especially female workers who are considered to be the most experiencing difficulties in work-life balance which can cause problems with work-life balance. The purpose of this study is to show 1) a description of the views or perceptions of female workers regarding work-life balance, 2) the psychological dynamics of female workers in balancing work-life in WFH and WFO situations, 3) the problems faced by female workers both internally and externally in achieving life balance. work in the new normal era, 4) adaptation of female workers to WFH and WFO situations and 5) strategies used to achieve work-life balance in the new normal . This study uses qualitative method with phenomenological approach. The subjects of this study were 5 female workers who were taken by snowball sampling technique using qualitative analysis using the Miles and Huberman models. The results show that female workers view work-life balance in the new normal as a positive thing. In work-life balance tends to have a negative impact on psychology. Post-pandemic changes (new normal) make female workers have to do multitasking resulting in problems in work-life balance. Adapting to WFH and WFO situations of female workers feel positive in work-life balance, which both internally and externally are very supportive to achieve work-life balance. The results of the above study also explain that female workers have effective strategies in work-life balance.
Keywords: Female workers, new normal, work-life balance
Hubungan efikasi diri dengan self-regulated learning siswa SMA dalam pembelajaran daring
Authors: Hidayatullah Muhammad Firdaus , Suryaningrum Cahyaning , Prasetyaningrum Susanti 
Published: August 2023

In the field of education during the pandemic, students must do online learning. The online learning process raises several problems in the form of low motivation, decreased academic achievement and grades, and less than optimal student activity during online learning to affect the less than optimal self-efficacy produced. Self-efficacy is a factor that can affect self-regulated learning in online learning. Students who have high self-efficacy, will increase student success in learning. However, if self-efficacy is low, students feel pressured in completing tasks that make it difficult to carry out learning strategies, which has an impact on self-efficacy. The purpose of this study was to determine the relationship between self-efficacy and self-regulated learning students in this online learning. The sample of this study amounted to 102 samples using accidental sampling techniques. The instruments used are the Self-Efficacy Scale and the Self-Regulated Learning Scale. The analysis technique used is the pearson product moment correlation test. The results showed that there was a significant positive relationship between self-efficacy and self-regulated learning of r = 0.675 (p < 0.05) where the higher the self-efficacy, the higher the self-regulated learning.
Keywords: High school students, online, self-efficacy, self-regulated learning
POTENSI NUTRIEN LIMBAH KULIT KOPI UNTUK PAKAN TERNAK RUMINANSIA DI KECAMATAN KEBUN TEBU KABUPATEN LAMPUNG BARAT
Authors: Aswanto Ahmad Andresta , Muhtarudin Muhtarudin , Farda Fitria Tsani , Liman Liman , Tantalo Syahrio 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui potensi limbah kulit kopi untuk pakan ternak ruminansia di Kecamatan Kebun Tebu Kabupaten Lampung Barat. Penelitian ini menggunakan metode survei. Adapun metode survei yang digunakan adalah purposive sampling. Kulit kopi yang diteliti potensi nutriennya adalah kopi robusta dalam bentuk segar dan bentuk kering. Kedua jenis kulit kopi tersebut diambil dari tiga desa yang ada di Kecamatan Kebun Tebu. Setiap satu sampel kulit kopi dari tiap Desa diuji dengan analisis proksimat lengkap. Hasil penelitian tiap sampel yang diambil dari enam Desa menunjukkan bahwa terdapat perbedaan kandungan nutrien antara kulit kopi segar dan kulit kopi kering. Kulit kopi kering memiliki nilai kandungan nutrien kadar air, protein kasar, lemak kasar, serat kasar, dan abu secara berturut-turut adalah 38,61%, 12,00%, 3,67%, 28,26%, 4,91%. Sementara kandungan kulit kopi segar memiliki nilai kandungan nutrien kadar air, protein kasar, lemak kasar, serat kasar, dan abu, secara berturut-turut adalah 10,88%, 15,23%, 2,53%, 25,28%, 6,96%. Berdasarkan tiga sampel buah kopi yang diambil, kulit kopi segar memiliki potensi yang lebih besar sebagai pakan ternak ruminansia jika dibandingkan dengan sampel kulit kopi kering. Kulit kopi segar masih memiliki presentasi bobot kulit kopi yang bisa dimanfaatkan sebesar 85% dari buah kopi. Sementara kulit kopi kering memiliki presentasi bobot sebesar 36%. Kapasitas tampung ternak ruminansia dengan asumsi pemberian 30% sebanyak 3388,79 unit ternak atau 3339 ekor, sementara kulit kopi segar sebanyak 3888,68 unit ternak atau 3.889 ekor. Sedangkan untuk asumsi pemberian 40% 2541,58 unit ternak atau sebanyak 2.541 ekor untuk limbah kulit kopi kering, dan kulit kopi segar yaitu 2916,50 unit ternak atau sebanyak 2.916 ekor.
PENGARUH SUPLEMENTASI SBM DAN MINERAL MIKRO ORGANIK (Zn dan Cr) TERHADAP RESPONS FISIOLOGIS KAMBING RAMBON
Authors: Maydasari Revita , Qisthon Arif , Muhtarudin Muhtarudin , Liman Liman 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pengaruh suplementasi SBM dan mineral mikro organik Zn dan Cr terhadap respons fisiologis kambing Rambon dan mengetahui perlakuan yang terbaik dalam ransum terhadap respons fisiologis kambing Rambon. Penelitian dilaksanakan di kandang Jurusan Peternakan, Fakultas Pertanian, Universitas Lampung pada November 2022 sampai dengan Desember 2022. Percobaan dilakukan pada 12 ekor kambing Rambon jantan, dengan Rancangan Acak Kelompok (RAK) yang terdiri dari 4 perlakuan dan 3 ulangan, kelompok dibagi berdasarkan bobot tubuh. Perlakuan pada penelitian ini yaitu P1: ransum basal (silase daun singkong, onggok, bungkil sawit, dan urea 35 g), P2: ransum basal 90%+SBM 10%, P3: ransum basal 100%+MO (40 ppm Zn+0,3 ppm Cr), P4: Ransum basal 90%+SBM 10%+MO (40 ppm Zn+0,3 ppm Cr). Data yang diperoleh dianalisis dengan Analysis of Variance (ANOVA) taraf nyata 5%. Peubah yang diamati adalah frekuensi respirasi, denyut jantung dan suhu rektal kambing Rambon. Pemberian ransum dengan SBM dan mineral mikro organik Zn dan Cr menunjukkan hasil berpengaruh tidak nyata (P>0,05) terhadap respons fisiologis kambing Rambon. Berdasarkan penelitian yang telah dilakukan dapat disimpulkan bahwa suplementasi SBM dan mineral mikro organik Zn dan Cr dalam ransum basal tidak berpengaruh terhadap frekuensi respirasi, denyut jantung, dan suhu rektal kambing Rambon.
PENGARUH PENGGUNAAN MIKORIZA DAN JENIS PUPUK BERBEDA PADA KONDISI CEKAMAN KEKERINGAN TERHADAP KANDUNGAN NUTRIEN (BK, PK, DAN SK) RUMPUT PAKCHONG
Authors: Usyifa Annisa , Liman Liman , Farda Fitria Tsani , Muhtarudin Muhtarudin 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan mikoriza dan jenis pupuk berbeda pada kondisi cekaman kekeringan terhadap kandungan nutrien (bahan kering, protein kasar, dan serat kasar) rumput pakchong. Penelitian ini dilaksanakan November 2022-Februari 2023 di Rumah Kaca Laboraturium Lapang Terpadu, Fakultas Pertanian, Universitas Lampung, Bandar lampung. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) Faktorial 2 faktor yang disusun dalam percobaan faktorial 4x3 dengan 3 ulangan. Perlakuan yang diberikan adalah kombinasi antara faktor petama yaitu M0: tanpa mikoriza, M1: 20 gram/ 10 kg tanah dalam polybag, M2: 40 gram/ 10 kg tanah dalam polybag, dan M3: 60 gram/ 10 kg tanah dalam polybag dengan faktor kedua yaitu P1: pupuk kotoran kambing (30 ton/ha), P2: pupuk NPK (urea 100 kg/ha ; TSP 50 kg/ha; KCl 50 kg/ha), dan P3: pupuk (kotoran kambing (30 ton/ha) + pupuk NPK (urea 100 kg/ha ; TSP 50 kg/ha; KCl 50 kg/ha)). Variabel yang diamati meliputi bahan kering, protein kasar, dan serat kasar. Data yang diperoleh akan dianalisis menggunakan Analisis Sidik Ragam dan dilanjutkan dengan Uji Lanjut Beda Nyata terkecil (BNt) pada taraf 5%. Hasil penelitian menunjukkan bahwa interaksi perlakuan tidak berpengaruh nyata (P>0,05) terhadap bahan kering, namun berpengaruh sangat nyata (P<0,05) terhadap protein kasar dan serat kasar. Pada protein kasar hasil tertinggi terdapat pada perlakuan M2P3 yaitu 16,08% dan pada serat kasar hasil tertinggi terdapat pada perlakuan M3P3 yaitu 33,58%.
IDENTIFIKASI POTENSI FINANCIAL DISTRESS MENGGUNAKAN RASIO KEUANGAN PADA PERUSAHAAN SEKTOR INDUSTRI MANUFAKTUR
Authors: Safa Azira Vella , Nuswandari Cahyani 
Published: August 2023

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh dari rasio likuiditas, rasio profitabilitas, rasio aktivitas, dan rasio leverage terhadap financial distress. Objek penelitian yang digunakan perusahaan sektor industri manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) periode 2017-2020. Penelitian ini menggunakan metode analisis regresi logistik. Teknik dalam pemilihan sampel yaitu nonprobability sampling dengan pendekatan purposive sampling yang menghasilkan sejumlah 649 data. Hasil penelitian menunjukkan bahwa rasio likuiditas tidak berpengaruh terhadap financial distress, rasio profitabilitas berpengaruh negatif terhadap financial distress, rasio aktivitas berpengaruh negatif terhadap financial distress, dan rasio leverage berpengaruh positif terhadap financial distress.
Kata Kunci: Rasio Likuiditas, Rasio Profitabilitas, Rasio Aktivitas, Rasio Leverage, Financial Distress
STRATEGI DAN BENTUK MANAJEMEN BIAYA SEBAGAI UPAYA SUSTAINABLE KEDAI KOPI PADA MASA PANDEMI COVID-19
Authors: Afrizal Yogi Hady , Tenri Pada Andi , Fatikah Indriaharti  
Published: August 2023

Penelitian ini bertujuan untuk mengetahui bagaimana strategi manajemen biaya dalam upaya sustainable kedai kopi se-Ajatappareng, Sulawesi Selatan pada masa pandemi Covid-19 dan bagaimana bentuk manajemen biaya kedai kopi se-Ajatappareng pada masa pandemi Covid-19. Adapun metode penelitian yang digunakan pada penelitian ini yaitu dengan pendekatan deskriptif kualitatif. Lokasi penelitian ini dilakukan di wilayah Ajatappareng yaitu Kota Pare-Pare, Kab. Pinrang dan Kab. Sidrap. Hasil penelitian menunjukkan bahwa setiap kedai kopi mempunya cara atau strategi tersendiri dalam menekan biaya selama pandemi agar dapat mempertahankan usaha. Meski mempunyai strategi yang berbeda, namun tujuan utama dari strategi tersebut yakni untuk bisa bertahan pasca pandemi kemudian kembali menata ulang usha yang sempai terpituk karena adanya pandemi Covid 19. Penelitian ini berimplikasi bahwa banyaknya usaha-usaha yang gulung tikar selama pandemic disebabkan tidak adanya strategi dalam menghadapi kondisi.
Kata Kunci: Strategi Manajemen; Manajemen Biaya dan Kedai Kopi