bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constitution of the fully supported gold(I)alkynyl (dmpme)·bis[gold(I)ethynyldimethylsilyl]methane in solution
Authors: Heinrichs Peter , Mix Andreas , Mitzel Norbert W. 
Published: May 2023

Abstract
The dimetallacyclic complex H2C(Me2SiC≡CAuPMe2)2CH2 has been synthesized, in which the two gold centers are bridged by the diphosphine dmpme (= bis(dimethylphosphino)methane) and a diethynyl ligand providing “full support” for the possible transannular Au–Au contact (3). This compound and its “semi-” and “unsupported” analogues (2, 1) have been characterized by NMR spectroscopy and elemental analysis. The monomeric nature of complex 3 in solution has been established using diffusion coefficients measured by DOSY-NMR spectroscopy and comparing the data with those of complexes 1 and 2 as references.
Evaluation and Validation of Commercially Available Dopamine Transporter Antibodies
Authors: Russo Emma E. , Zovko Lola E. , Nazari Reza , Steenland Hendrik , Ramsey Amy J. , Salahpour Ali 
Published: May 2023

AbstractWith a wide variety of dopamine transporter (DAT) antibodies available commercially, it is important to validate which antibodies provide sufficient immunodetection for reproducibility purpose and for accurate analysis of DAT levels and/or location. Commercially available DAT antibodies that are commonly used were tested in western blotting (WB) on wild-type (WT) and DAT-knock-out (DAT-KO) brain tissue and with immunohistology (IH) techniques against coronal slices of unilaterally lesioned 6-OHDA rats, in addition to wild-type and DAT-knock-out mice. DAT-KO mice and unilateral 6-OHDA lesions in rats were used as a negative control for DAT antibody specificity. Antibodies were tested at various concentrations and rated based on signal detection varying from no signal to optimal signal detection. Commonly used antibodies, including AB2231 and PT-22 524-1-AP, did not provide specific DAT signals in WB and IH. Although certain antibodies provided a good DAT signal, such as SC-32258, D6944, and MA5-24796, they also presented nonspecific bands in WB. Many DAT antibodies did not detect the DAT as advertised, and this characterization of DAT antibodies may provide a guide for immunodetection of DAT for molecular studies.
Intracranial Electroencephalography and Deep Neural Networks Reveal Shared Substrates for Representations of Face Identity and Expressions
Authors: Schwartz Emily , Alreja Arish , Richardson R. Mark , Ghuman Avniel , Anzellotti Stefano 
Published: May 2023

According to a classical view of face perception (Bruce and Young, 1986; Haxby et al., 2000), face identity and facial expression recognition are performed by separate neural substrates (ventral and lateral temporal face-selective regions, respectively). However, recent studies challenge this view, showing that expression valence can also be decoded from ventral regions (Skerry and Saxe, 2014; Li et al., 2019), and identity from lateral regions (Anzellotti and Caramazza, 2017). These findings could be reconciled with the classical view if regions specialized for one task (either identity or expression) contain a small amount of information for the other task (that enables above-chance decoding). In this case, we would expect representations in lateral regions to be more similar to representations in deep convolutional neural networks (DCNNs) trained to recognize facial expression than to representations in DCNNs trained to recognize face identity (the converse should hold for ventral regions). We tested this hypothesis by analyzing neural responses to faces varying in identity and expression. Representational dissimilarity matrices (RDMs) computed from human intracranial recordings (n= 11 adults; 7 females) were compared with RDMs from DCNNs trained to label either identity or expression. We found that RDMs from DCNNs trained to recognize identity correlated with intracranial recordings more strongly in all regions tested—even in regions classically hypothesized to be specialized for expression. These results deviate from the classical view, suggesting that face-selective ventral and lateral regions contribute to the representation of both identity and expression.SIGNIFICANCE STATEMENTPrevious work proposed that separate brain regions are specialized for the recognition of face identity and facial expression. However, identity and expression recognition mechanisms might share common brain regions instead. We tested these alternatives using deep neural networks and intracranial recordings from face-selective brain regions. Deep neural networks trained to recognize identity and networks trained to recognize expression learned representations that correlate with neural recordings. Identity-trained representations correlated with intracranial recordings more strongly in all regions tested, including regions hypothesized to be expression specialized in the classical hypothesis. These findings support the view that identity and expression recognition rely on common brain regions. This discovery may require reevaluation of the roles that the ventral and lateral neural pathways play in processing socially relevant stimuli.
Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures
Authors: Nanba Daisuke , Sakabe Jun‐Ichi , Mosig Johannes , Brouard Michel , Toki Fujio , Shimokawa Mariko , Kamiya Mako , Braschler Thomas , Azzabi Fahd , Droz‐Georget Lathion Stéphanie , Johnsson Kai , Roy Keya , Schmid Christoph D , Bureau Jean‐Baptiste , Rochat Ariane , Barrandon Yann 
Published: May 2023

AbstractAdult autologous human epidermal stem cells can be extensively expanded ex vivo for cell and gene therapy. Identifying the mechanisms involved in stem cell maintenance and defining culture conditions to maintain stemness is critical, because an inadequate environment can result in the rapid conversion of stem cells into progenitors/transient amplifying cells (clonal conversion), with deleterious consequences on the quality of the transplants and their ability to engraft. Here, we demonstrate that cultured human epidermal stem cells respond to a small drop in temperature through thermoTRP channels via mTOR signaling. Exposure of cells to rapamycin or a small drop in temperature induces the nuclear translocation of mTOR with an impact on gene expression. We also demonstrate by single‐cell analysis that long‐term inhibition of mTORC1 reduces clonal conversion and favors the maintenance of stemness. Taken together, our results demonstrate that human keratinocyte stem cells can adapt to environmental changes (e.g., small variations in temperature) through mTOR signaling and constant inhibition of mTORC1 favors stem cell maintenance, a finding of high importance for regenerative medicine applications.
‘It all depends on why it’s red’: qualitative interviews exploring patient and professional views of a traffic light system for in vitro fertilisation add-ons
Authors: Lensen Sarah , Armstrong Sarah , Vaughan Emily , Caughey Lucy , Peate Michelle , Farquhar Cynthia , Pacey Allan , Balen Adam , Wainwright Elaine 
Published: May 2023

In vitro fertilisation (IVF) add-ons are techniques, medicines, or procedures used in addition to standard IVF with the aim of improving the chance of success. The United Kingdom’s IVF regulator, the Human Fertilisation Embryology Authority (HFEA) developed a traffic light system to categorise add-ons as either green, amber, or red, based on results of randomised controlled trials. We undertook qualitative interviews to explore understanding and views of the HFEA traffic light system among IVF clinicians, embryologists, and IVF patients across Australia and the United Kingdom (n = 73). Overall, participants were supportive of the intention of the traffic light system; however, many limitations were raised. It was widely recognised that a simple traffic light system necessarily omits information which may be important to understanding the evidence. In particular, the red category was used in scenarios that patients viewed as having different implications for their decision-making, including ‘no evidence’ and ‘evidesssnce of harm’. Patients were surprised at the absence of any green add-ons and questioned the value of a traffic light system in this context. Many participants considered the website a helpful starting point, but desired more detail, including the contributing studies, results specific to patient demographics (e.g. <35 years and >35 years), and inclusion of more options (e.g. acupuncture). Overall, participants believed the website to be reliable and trustworthy, particularly due to the Government affiliation, and despite some concerns regarding transparency and an overly cautious regulator. The limitations of the traffic light system could be considered in any future updates to the HFEA website and others developing similar decision support tools.

Lay summary
In vitro fertilisation (IVF) add-ons are medical procedures or technologies that may be used in addition to standard IVF. They are usually used with the aim of increasing the chance of pregnancy and live birth. However, most add-ons have not been studied in high-quality clinical trials so it is uncertain whether they are beneficial. The UK’s IVF regulator developed a traffic light system for add-ons. They label them red, amber, or green, depending on whether there is evidence the add-on increases the chance of having a baby from IVF. We interviewed IVF patients, IVF doctors, and embryologists about the traffic light system. Overall, many people thought it was a reliable and trustworthy resource – however, many problems were identified. People generally thought the system was too simple and didn’t give enough information, it had limited detail about the number and types of studies included, and some important add-ons were missing, such as acupuncture.
Cyber Literacy Skills of Estonians: Activities and Policies For Encouraging Knowledge-Based Cyber Security Attitudes
Authors: Kont Kate-Riin 
Published: May 2023

With the advent of COVID-19, people spent more time at home. Countries, societies, companies and individuals suddenly became dependent on cyberspace overnight. Work, shopping and leisure meant we became more than ever weak to the risks of cyberspace. The human factor makes people the “key” to otherwise technically hardly penetrable systems – criminals play on people’s greed, emotions, happiness, etc.
It is no surprise that Estonians are more active daily internet users compared to the rest of the Europeans. But what is being done in Estonia at the national level, as well as in cyber protection organisational level, to raise the awareness of residents about cyber security? What else should be done to reduce victims among ordinary citizens and how to protect various important public and private organisations from the consequences of the cyber-risky behaviour of their employees? What is the role of libraries in promoting cyber security awareness? A human error is a central target of cyber attacks, phishing scams, and data breaches. Cyber criminals are becoming more and more inventive. It is important to understand that cyber security risks can be managed and mitigated, but not completely eliminated. Increasing security awareness is the only factor that can help limit breaches caused by human frailty.
On the current psychotherapeutic situation for persons with pornography use disorder in Germany
Authors: Markert Charlotte , Storz Florian , Golder Sarah , Rechmann Johanna , Rubel Julian A. , Lalk Christopher , Vogt Rabea , Glombiewski Julia A. , Braun David , Pané-Farré Christiane A. , Michael Tanja , Mattheus Hannah K. , Dominick Nanne , Wölfling Klaus , Lutz Wolfgang , Schaffrath Jana , Stangier Ulrich , Kananian Schahryar , Strüwing Dirk , Klingelhöfer Doerthe , Valbert Frederik , Neumann Anja , Walter Bertram , Stark Rudolf 
Published: May 2023

AbstractBackground and aimsFor the first time, the ICD-11 provides the diagnosis compulsive sexual behavior disorder (CSBD) that can be assigned for pornography use disorder (PUD). This study aimed to estimate the prevalence of PUD and associated consequences in Germany, to identify the psychotherapy demand among likely PUD (lPUD) cases and the treatment supply in different psychotherapeutic settings, to survey psychotherapists' level of expertise regarding PUD, and to identify predictors for psychotherapy demand.MethodsFour studies were conducted: 1. Online study in the general population (n = 2070; m = 48.9%, f = 50.8%, d = 0.2%), 2. Survey among practicing psychotherapists (n = 983), 3. Survey of psychotherapists in psychotherapeutic outpatient clinics (n = 185), 4. Interviews with psychotherapeutic inpatient clinics (n = 28).ResultsThe estimated prevalence of lPUD in the online study was 4.7% and men were 6.3 times more often affected than women. Compared to individuals without PUD, individuals with lPUD more often indicated negative consequences in performance-related areas. Among lPUD cases, 51.2% of men and 64.3% of women were interested in a specialized PUD treatment. Psychotherapists reported 1.2%–2.9% of lPUD cases among their patients. 43.2%–61.5% of psychotherapists stated to be poorly informed about PUD. Only 7% of psychotherapeutic inpatient clinics provided specific treatments to patients with PUD. While, among other factors, negative consequences attributed to lPUD were predictive for psychotherapy demand, weekly pornography consumption, subjective well-being, and religious attachment were not.Discussion and conclusionsAlthough PUD occurs quite often in Germany, availability of mental health care services for PUD is poor. Specific PUD treatments are urgently needed.
The evolution of downstream global value chains in Eastern Europe
Authors: Vakhal Péter 
Published: May 2023

AbstractWhile international value chains have been present in planned economies for several decades, their integration into global value chains (GVCs) began in the 1990s. In this study, we investigated the evolution of downstream value chains in Eastern Europe (including the Balkan countries, Moldova, and Ukraine) from 1995, by applying Wang's UIBE methodology and the Eora database. The results of this study suggest that European Union (EU) membership indisputably has a positive impact on GVC embeddedness, whereas non-EU economies are still integrated in their own local downstream value chains. We further investigated the automotive sector in the Central and Eastern European countries and demonstrate how deeper integration into GVCs prompted the emergence of assembly activities.
Rethinking circular economy for electronics, energy storage, and solar photovoltaics with long product life cycles
Authors: Sahajwalla Veena , Hossain Rumana 
Published: May 2023

AbstractDevelopments in recycling technology have largely focused on short-life-cycle products, such as plastic waste from packaging, consumer electronics, and construction debris, while complex, resource-rich, long-life-cycle electronic products, energy-storage, and photovoltaic components have been somewhat overlooked due to their intrinsic property of containing multimaterial in a complex manner. High-value products contain valuable elements, which are intricately incorporated and often lost at end of life. This article explores the need for a paradigm shift to a “product-centric” approach, which emphasizes the circularity of the whole product, with an emphasis on more focused ways of combining design and recovery methods. Opportunities for improved circularity include design for disassembly through modular approaches, development of materials for substitution, fabrication efficiency through novel selective synthesis of metals, high-throughput manufacturing of precision devices, and manufacturing processes that enable use of recycled materials for product. Design efforts should focus on current perceived limits in the degree of modularity, where parts can be made accessible for replacement and consumer uptake of recycled product.
Graphical abstract
Economia e ética religiosa: afinidades eletivas entre a Ética da Libertação e a Economia Solidária
Authors: Souza Josué de , Schiochet Valmor 
Published: May 2023

O presente artigo é parte da pesquisa realizada para a tese de doutoramento em Desenvolvimento Regional no Programa de Pós-Graduação em Desenvolvimento Regional da Universidade Regional de Blumenau. Objetiva compreender a influência da ética religiosa e o espírito da economia solidária. Especificamente procura sistematizar as contribuições teóricas sobre a relação entre religião e economia; identificar as características e os princípios normativos da economia solidária; analisar as contribuições da ética da libertação para a crítica do capitalismo na América Latina; relacionar as afinidades entre a ética religiosa de libertação e a economia solidária. Do ponto e vista empírico é uma análise de textos e documentos pertencentes a chamada Teologia da Libertação e dos escritos do economista Paul Singer.
Territorialidade e representação neopentecostais: quando política e religião se entrecruzam
Authors: Júnior Isley Borges da Silva , Enoque Alessandro Gomes , Saraiva Luiz Alex Silva 
Published: May 2023

Este trabalho teve, por objetivo, compreender as relações existentes entre as temáticas da territorialidade e da representação de natureza política na perspectiva de membros de uma igreja neopentecostal de uma cidade do interior de Minas Gerais. Partindo de uma abordagem qualitativa, pôde-se observar que a igreja neopentecostal pesquisada apresenta uma territorialidade de natureza fluida, pulverizada, bem como menos centralizada (convite para a participação de novos membros em ocasiões menos formais, participação dos líderes religiosos em outras instituições, abertura de "filiais" da igreja em outras cidades, influência religiosa a partir da atuação de/em pequenos grupos). Parece haver, ainda, certo distanciamento da política tradicional e uma valorização de candidatos com valores cristãos.
Ensino religioso escolar nos votos do STF: a religião como crença
Authors: Montero Paula 
Published: May 2023

Este artigo examina os argumentos dos 11 ministros do Supremo Tribunal Federal do Brasil que, em 2017, decidiram pela constitucionalidade da oferta de ensino confessional na escola pública. Trata-se de analisar como valores éticos e jurídicos em disputa na longa duração se rearticulam nestes votos em torno da noção de crença, passados quase 40 anos da definição do Ensino Religioso como direito humano fundamental pela Constituição brasileira. Não se trata de voltar ao tema do secularismo seja como processo social seja como norma jurídica ou doutrina política. A análise das formulações discursivas dos votos dos ministros busca, ao contrário, desvendar as diferentes construções do religioso implicadas no uso dos termos religião e direitos e compreender como elas operam na projeção de uma ideia de cidadania e/ou da nação. Pretende-se tornar mais evidente, a partir desse exame sistemático dos votos, a configuração do senso comum jurídico quando se trata de emitir juízos de valor sobre o religioso e sua proteção. Para tanto, teremos como principal foco circunscrever o que, nessas narrativas jurídicas, conta como religião.
Comprehensive Approach to Developing Baseline Reference Ranges for Platelet Function
Authors: Gordeeva Olga B. , Karaseva Maria S. , Lastovka Vasily A. , Vashakmadze Nato D. , Soloshenko Margarita A. , Revunenkov Gregory V. , Valyalov Kirill A. , Altunin Viktor V. 
Published: May 2023

Background. Thrombocytopathies are topical issues of pediatrics. Platelet dysfunction clinically manifests as thrombotic and hemorrhagic events of various severity and location. Platelet function can be evaluated via aggregatometry. Specified parameters for aggregatometry can be used in pediatrics as a standard for evaluating platelet function in peripheral blood. There were no similar studies in children in Russian Federation.Objective. The aim of the study is — to justify the significance of reference ranges (RR) development for platelet aggregatometry in pediatrics.Methods. The study included 30 relatively healthy patients aged from 1 to 18 years. Laboratory tests included complete blood count via automatic hematological analyzer; platelet aggregation in whole blood was evaluated via impedance aggregometer; plasmic hemostasis component (Quick prothrombin), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen were evaluated on automatic coagulation analyzer; molecular genetic study of platelet genes polymorphisms was performed via real-time PCR. Several inducers were used to study platelet aggregation: thrombin receptor activating peptide (TRAP), adenosine diphosphate (ADP), arachidonic acid (ASPI). Instrumental methods included electrocardiography, ultrasound of abdomen, urinary system, and thyroid gland.Results. The study included 16 girls and 14 boys. The median age was 9.4, interquartile range (IQR) was 6.5; 14,1. RR for platelet aggregation indicators were determined for all aggregation inducers (thrombin, ADP, arachidonic acid) as a result of the study.Conclusion. The obtained data will allow to improve the diagnosis approach for platelet dysfunction regarding the established reference ranges. The results of further research may contribute in the development of the algorithm for controlling antiplatelet therapy in patients with contraindications or with genetically determined low sensitivity to thrombocyte aggregation inhibitors based on acetylsalicylic acid.
Investigating the Dimensionality of Young’s Internet Addiction Test for University Students Using Mokken Scale Analysis
Authors: AVCU Akif 
Published: May 2023

The Internet Addiction Test has been used extensively by researchers to collect data from university students, However, empirical studies on the psychometric properties of this test have revealed conflicting results on the factor structure. Although the structure of Internet addiction is generally accepted as unidimensional, these contradictory results require further evidence for the unidimensional nature of the construct. Considering the existing problems regarding the factor structure of the Internet Addiction construct, the aim of this study was set as evaluating the unidimensionality of the Short Internet Addiction Test for University Students by using Mokken Scaling Analysis. The Internet Addiction Test short form was administered to 636 university students studying in Turkey in the 2020-21 academic year via an online data collection platform. The ages of the participants ranged from 20 to 65. The results revealed that the items of the Internet Addiction Test Short Form were scalable and homogeneous enough to form a separate scale. On the other hand, the results showed that the Internet Addiction Test Short Form did not have the Invariant Item Ranking feature. In addition, using the backward selection method, a seven-item form of the Internet Addiction Test Short Form, which has Invariant Item Ordering feature, is proposed. These results showed that the structure of internet addiction can be accepted as one-dimensional for Turkish university students. It is recommended to examine whether the results obtained in future studies can be generalized to different universes.
Keywords: Mokken scaling analysis, internet addiction, dimensionality, university students.