bluuebunny/crossref_metadata_2025_split huggingface dataset:
ATP sulfurylase atypical leucine zipper interacts with Cys3 and calcineurin A in the regulation of sulfur amino acid biosynthesis in Cryptococcus neoformans
Authors: da Silva Jeyson Pereira , Meneghini Mariana Reis , Santos Ronaldo Silva , Alves Verônica Lira , da Cruz Martho Kevin Felipe , Vallim Marcelo Afonso , Pascon Renata Castiglioni 
Published: July 2023

AbstractFungal pathogens are a major cause of death, especially among immunocompromised patients. Therapies against invasive fungal infections are restricted to a few antifungals; therefore, novel therapies are necessary. Nutritional signaling and regulation are important for pathogen establishment in the host. In Cryptococcus neoformans, the causal agent of fungal meningitis, amino acid uptake and biosynthesis are major aspects of nutritional adaptation. Disruptions in these pathways lead to virulence attenuation in an animal model of infection, especially for sulfur uptake and sulfur amino acid biosynthesis. Deletion of Cys3, the main transcription factor that controls these pathways, is the most deleterious gene knockout in vitro and in vivo, making it an important target for further application. Previously, we demonstrated that Cys3 is part of a protein complex, including calcineurin, which is necessary to maintain high Cys3 protein levels during sulfur uptake and sulfur amino acid biosynthesis. In the current study, other aspects of Cys3 regulation are explored. Two lines of evidence suggest that C. neoformans Cys3 does not interact with the F-box WD40 protein annotated as Met30, indicating another protein mediates Cys3 ubiquitin degradation. However, we found another level of Cys3 regulation, which involves protein interactions between Cys3 and ATP sulfurylase (MET3 gene). We show that an atypical leucine zipper at the N-terminus of ATP sulfurylase is essential for physical interaction with Cys3 and calcineurin. Our data suggests that Cys3 and ATP sulfurylase interact to regulate Cys3 transcriptional activity. This work evidences the complexity involved in the regulation of a transcription factor essential for the sulfur metabolism, which is a biological process important to nutritional adaptation, oxidative stress response, nucleic acid stability, and methylation. This information may be useful in designing novel therapies against fungal infections.
Application of a generative adversarial network for multi-featured fermentation data synthesis and artificial neural network (ANN) modeling of bitter gourd–grape beverage production
Authors: Gbashi Sefater , Maselesele Tintswalo Lindi , Njobeh Patrick Berka , Molelekoa Tumisi Beiri Jeremiah , Oyeyinka Samson Adeoye , Makhuvele Rhulani , Adebo Oluwafemi Ayodeji 
Published: July 2023

AbstractArtificial neural networks (ANNs) have in recent times found increasing application in predictive modelling of various food processing operations including fermentation, as they have the ability to learn nonlinear complex relationships in high dimensional datasets, which might otherwise be outside the scope of conventional regression models. Nonetheless, a major limiting factor of ANNs is that they require quite a large amount of training data for better performance. Obtaining such an amount of data from biological processes is usually difficult for many reasons. To resolve this problem, methods are proposed to inflate existing data by artificially synthesizing additional valid data samples. In this paper, we present a generative adversarial network (GAN) able to synthesize an infinite amount of realistic multi-dimensional regression data from limited experimental data (n = 20). Rigorous testing showed that the synthesized data (n = 200) significantly conserved the variances and distribution patterns of the real data. Further, the synthetic data was used to generalize a deep neural network. The model trained on the artificial data showed a lower loss (2.029 ± 0.124) and converged to a solution faster than its counterpart trained on real data (2.1614 ± 0.117).
Predicting sepsis onset using a machine learned causal probabilistic network algorithm based on electronic health records data
Authors: Valik John Karlsson , Ward Logan , Tanushi Hideyuki , Johansson Anders F. , Färnert Anna , Mogensen Mads Lause , Pickering Brian W. , Herasevich Vitaly , Dalianis Hercules , Henriksson Aron , Nauclér Pontus 
Published: July 2023

AbstractSepsis is a leading cause of mortality and early identification improves survival. With increasing digitalization of health care data automated sepsis prediction models hold promise to aid in prompt recognition. Most previous studies have focused on the intensive care unit (ICU) setting. Yet only a small proportion of sepsis develops in the ICU and there is an apparent clinical benefit to identify patients earlier in the disease trajectory. In this cohort of 82,852 hospital admissions and 8038 sepsis episodes classified according to the Sepsis-3 criteria, we demonstrate that a machine learned score can predict sepsis onset within 48 h using sparse routine electronic health record data outside the ICU. Our score was based on a causal probabilistic network model—SepsisFinder—which has similarities with clinical reasoning. A prediction was generated hourly on all admissions, providing a new variable was registered. Compared to the National Early Warning Score (NEWS2), which is an established method to identify sepsis, the SepsisFinder triggered earlier and had a higher area under receiver operating characteristic curve (AUROC) (0.950 vs. 0.872), as well as area under precision-recall curve (APR) (0.189 vs. 0.149). A machine learning comparator based on a gradient-boosting decision tree model had similar AUROC (0.949) and higher APR (0.239) than SepsisFinder but triggered later than both NEWS2 and SepsisFinder. The precision of SepsisFinder increased if screening was restricted to the earlier admission period and in episodes with bloodstream infection. Furthermore, the SepsisFinder signaled median 5.5 h prior to antibiotic administration. Identifying a high-risk population with this method could be used to tailor clinical interventions and improve patient care.
Dynamic response of deepwater test string under fluctuations in axial force and internal pressure
Authors: Sun Qiaolei , Liu Yuwei , Deng Long , Wang Jiangang , Feng Ding 
Published: July 2023

AbstractIn this study, a mechanical model suitable for deepwater test string was proposed. An analysis of the dynamic response of the test string under different frequencies, different water depths and different fluctuation amplitudes was carried out by using the finite element method based on the change in the internal pressure and axial force measured. The results of the analysis showed that the response parameters (maximum stress and maximum deformation) tended to be stable after one period of fluctuation in the axial force and half a period of fluctuation in the internal pressure, respectively. When a sine waveform fluctuation in the internal pressure and axial force occurred, the response parameters increased with an increase in the amplitude of the fluctuation and increased with an increase in the frequency of fluctuation, and the amplitude of variation decreased with an increase in the fluctuation period. Under fluctuation in the axial force, the response parameter decreased with an increase in the water depth. The response parameter decreased first and then increased with an increase in the water depth when the fluctuation in the internal pressure occurred with a sine waveform. The maximum deformation and stress of the test string always changed with a change in the load when the fluctuation in the internal pressure and axial force had a sine waveform, and the test string under a load with a sine waveform was prone to periodic fatigue failure. The relevant conclusions provide a basis for the analysis and prevention of fatigue failure in test strings.
Design and analysis of a novel fast adder using logical effort method
Authors: Tavakolaee Hamid , Ardeshir Gholamreza , Baleghi Yasser 
Published: July 2023

AbstractAddition, as one of the fundamental math operations, is applied widely in Very‐large‐scale integration systems and digital signal processing, such that the computational speed of a system depends mainly on the computational speed of its adders. There are various types of digital adders based on different methods. A novel adder is proposed which performs addition based on a path with a fewer number of levels, and, hence, with higher computational speed and lower power consumption. The goal and innovation is to design a structured fast adder that has a block that can be expanded to higher bits, and in this design, the calculation speed and power consumption of the proposed circuit are optimal. Each proposed adder circuit has several levels, and the formulae of each level are stated. Each level of the circuit is designed with a number of multiplexers and OR gates. The performance of the proposed adder has been investigated and evaluated in two parts of mathematical calculations and simulation, and it has also been compared with other existing fast adders, such as ripple carry adder, carry skip adder, carry select adder, carry look ahead adder and prefix kogge‐stone in cases of 8, 16, 32 and 64 bits. The results show that the proposed collector has a good performance compared to other adders‐based power consumption, power delay product and delay area product metrics.
Women with disabilities’ experiences of intimate partner violence: a qualitative study from Sweden
Authors: Anyango Cartrine , Goicolea Isabel , Namatovu Fredinah 
Published: July 2023

Abstract
Background
Intimate Partner Violence (IPV) is a prevalent form of gender-based violence affecting one in three women globally. It is also a preventable cause of ill-health, disability, and death. Current research suggests that women with disabilities are at a significantly higher risk of experiencing violence throughout their lifetime. They are almost twice as likely to experience violence compared to men with disabilities or men and women without disabilities. Additionally, they experience higher rates of all types of violence. This increased vulnerability may be due to factors related to disability such as dependence on others for support, mistrust, and social and physical isolation. Although there is existing research on IPV against women in general, there is limited knowledge on IPV against women with disabilities. To address this gap in knowledge, this study aimed to explore women with disabilities’ perceptions and experiences of being victims/survivors of IPV in Sweden.

Methods
This was a qualitative study conducted through in-depth interviews with eleven women with disabilities. The participants were aged eighteen years upwards. The collected data was analyzed using reflexive thematic analysis with a constructivist epistemological standpoint.

Results
We developed four themes. Theme one: “multiple abuse by multiple abusers, over time,” describes the participants’ experiences of various types of violence from different perpetrators for prolonged periods. Theme two: “psychological abuse—harmful, but neglected and difficult to prove,” explains how women with disabilities’ perceive psychological abuse as harmful, but not given the same level of seriousness as physical violence. It also expresses the difficulties they encountered in providing tangible evidence to prove instances of psychological abuse. Theme three: “abuse does not end with separation,” highlights how abuse can continue beyond separation/divorce. Theme four: “surviving abusive relationships” describes the different and evolving ways the participants used to navigate their abusive relationships.

Conclusions
Women with disabilities face all forms of abuse. They find it challenging to prove psychological abuse, and the system is inadequate in addressing its harm. The abuse also continues after separation or divorce. The support system should consider the needs of women with disabilities who experience violence, both during and after the abusive relationship. Service providers should be better equipped to detect and handle all types of IPV, especially psychological abuse.
SIMULATION RESULTS OF THE TIDAL CURRENT REGIME IN CAMRANII BAY USING .FINITE ELEMENT METHOD
Authors: Long Bui Hong , Chung Tran Van 
Published: July 2023

In this paper we present the experimental simulation results of the tidal currents in Cam Ranh bay, Thuy Trieu lagoon area. Finite element method was used here due to the follwing reasons: - The bottom topography of the research area is complex (bay, lagoon), and the boundary conditions are sufficient (the fluid boundary is narrow). - Measured data on the research area are comprehensive, which will enable the comparision with the calculated results. - This model has already been tested in the proposed physical environment. The simulation results of the tidal currents in Cam Ranh bay show that: - There are two typical tidal stages occuring at flood tide phase (tidal currents coming into the bay). Stage 1: The maximum tidal current directions are west-northwestward, maximum velocity of tidal currents reached 103.4 cm/s. Stage II: The peak tidal current directions are mainly north-northeastward, maximum of the peak currents at this stage was decreased by nearly 50% in comparison with stage I, reached 53.4 cm/s. -At ebb tide phase (tidal currents going out the bay), the peak tidal currents are mainly south -southwestward and their velocity may reach up to 129.6 cm/s. The comparison between calculated results and measured data of tidal currents collectedfrom 23 field stations shows that both data agree well with each other. The deviation of velocity between the measured data and maximum calculated data is 2.7 cm/s, average 0.8 cm/s, according to their absolute values. The maximum deviation of current direction is about 9.90, average is 2.60 These compared results are quite good, however they are just initial results. The model will be further developed and improved in the coming time.
El riesgo de radicalización entre jóvenes inmigrantes. Orientaciones para su prevención desde la intervención social
Authors: Palma García María de las Olas , Arredondo Quijada Rafael , Castilla Mora Rosario 
Published: July 2023

El fenómeno de radicalización extremista constituye una realidad en continuo cambio y preocupación entre nuestras sociedades, alertando numerosos estudios sobre la situación de colectivos de menores pertenecientes a entornos vulnerables, como los jóvenes inmigrantes, que se encuentran expuestos a su captación y reclutamiento. Se realiza el presente trabajo a través de un estudio Delphi con la finalidad de ofrecer una mayor comprensión del proceso de radicalización en estos jóvenes. En el estudio participan trece panelistas, seleccionados de manera discrecional entre personas profesionales expertas en intervención social con jóvenes inmigrantes y académicas e investigadoras de reconocida relevancia en procesos de radicalización. Tomando como referencia la herramienta VERA-2, los expertos muestran su grado de acuerdo respecto a la relevancia y presencia de los factores asociados al proceso de radicalización en jóvenes inmigrantes tanto de opinión como de acción. En general, los resultados alcanzan mayores niveles de acuerdo respecto a la presencia de factores actitudinales tales como el odio, frustración, rechazo hacia la sociedad y sus valores, problemas de identidad colectiva y percepción de injusticia. Se identifica que dichos factores aparecen con mayor fuerza en los momentos iniciales en los que los jóvenes comienzan a relacionarse con el mundo extremista, tanto en la radicalización de la opinión como de la acción, pudiéndose establecer a partir de ellos indicadores para la detección de posibles procesos de captación. Con los resultados obtenidos se espera sumar nuevas orientaciones en las prácticas y políticas que favorezcan la prevención del extremismo violento entre los jóvenes inmigrantes.
Rôles Et Faiblesses Des Acteurs Dans La Mise En Œuvre Des Mesures Environnementales Des Projets D’aménagement Routier Au Bénin
Authors: Arsène DAGA Dossou , Eustache Zokpénou QUENUM Comlan Irené , Thierry AGBANOU B. , Roméo CHABI , Josée E. GNELE , Brice TENTE H. A. 
Published: July 2023

La gouvernance environnementale des projets d’aménagement routier est une préoccupation des pouvoirs publics, des partenaires techniques et financiers et des différentes parties prenantes de la société. Au Bénin, cette activité est confrontée à des difficultés qui entachent parfois la mise en œuvre des outils de protection de l’environnement. L’objectif de cette recherche est d’analyser les responsabilités et les faiblesses des acteurs intervenant dans la mise en œuvre de l’aménagement des projets routiers au Bénin.L’approche méthodologique utilisée a consisté en une recherche documentaire et à la collecte de données à travers des entretiens avec des personnes-ressources et responsables d’institutions. Au total vingt-six (26) entretiens individuels et seize (16) focus groupes ont été réalisés. Avant le traitement proprement dit, un dépouillement annuel des données a été fait. Ces données ont été ensuite transcrites et classées selon les centres d’intérêt. Le modèle SWOT a permis d’analyser les résultats obtenus.Il ressort des résultats obtenus que des projets d’aménagement routier au Bénin n’ont pas bénéficié d’Étude d’Impact Environnemental et Social (EIES). Pour ceux qui en ont bénéficié, le Plan de Gestion Environnemental et Social (PGES) n’est pas correctement mise en œuvre. Plusieurs facteurs expliquent cette non mise en œuvre des mesures environnementales et sociales. En effet, les différentes structures impliquées dans la gestion environnementale et sociale des projets d’aménagement routier n’ont pas joué pleinement leurs rôles pour des raisons logistiques, économiques, administratives, institutionnelles et politiques. Ainsi, de 2014 à 2018 sur un total de cent seize (116) suivi de PGES programmés, seulement 41 ont fait l’objet de suivi, soit un ratio de 35%.
Total Structure, Electronic Structure and Catalytic Hydrogenation Activity of Metal‐Deficient Chiral Polyhydride Cu57 Nanoclusters
Authors: Luo Geng‐Geng , Pan Zhong‐Hua , Han Bao‐Liang , Dong Guang‐Lei , Deng Cheng‐Long , Azam Mohammad , Tao Yun‐Wen , He Jiao , Sun Cun‐Fa , Sun Di 
Published: July 2023

AbstractAccurate identifying and in‐depth understanding of the defect sites in a working nanomaterial could hinge on establishing specific defect‐activity relationships. Yet, atomically precise coinage‐metal nanoclusters (NCs) possessing surface vacancy defects are scarce primarily owing to challenges in the synthesis and isolation of such defective NCs. Herein we report a mixed‐ligand strategy to synthesizing an intrinsically chiral and metal‐deficient copper hydride‐rich NC [Cu57H20(PET)36(TPP)4]+ (Cu57H20). Its total structure (including hydrides) and electronic structure are well established by combined experimental and computational results. Crystal structure reveals Cu57H20 features a cube‐like Cu8 kernel embedded in a corner‐missing metal‐ligand shell of Cu49(PET)36(TPP)4. Single Cu vacancy defect site occurs at one corner of the shell, evocative of mono‐lacunary polyoxometalates. Theoretical calculations demonstrate that the above‐mentioned point vacancy causes one surface hydride exposed as an interfacial capping μ3‐H−, which is accessible in chemical reaction, as proved by deuterated experiment. Moreover, Cu57H20 shows catalytic activity in the hydrogenation of nitroarene. The success of this work opens the way for the research on well‐defined chiral metal‐deficient Cu and other metal NCs, including exploring their application in asymmetrical catalysis.
Dauricine exhibits anti‐inflammatory property against acute ulcerative colitis via the regulation of NF‐κB pathway
Authors: Zhang Xu , Wang Ting , Miao Yu , Lin Wan , Zhu Litao , Meng Xiangkun , Zhang Feixiong 
Published: July 2023

AbstractWe aim to investigate the therapeutic effect of dauricine on ulcerative colitis (UC). Our results indicated that dauricine attenuated the reduction of colonic length, weight loss, disease activity index, colonic tissue damage, and inflammatory cytokine levels in dextran sulfate sodium mice. In addition, dauricine reduced lipopolysaccharide‐induced inflammation in HT‐29 cells. Mechanically, dauricine docked with p65, a member of nuclear transcription factor kappaB (NF‐κB) family, through which reduced the inflammatory cytokine release from HT‐29 cells. Together, the above results inferred that dauricine had therapeutic effect for UC by suppressing NF‐κB pathway, which provided a promising mean for UC treatment.
The expression of tuftelin 1 as a new theranostic marker in early diagnosis and as a therapeutic target in hepatocellular carcinoma
Authors: Abdel‐Hamid Nabil M. , Zakaria Sherin M. , Ansary Abeer M. , El‐Senduny Fardous F. , El‐Shishtawy Mamdouh M. 
Published: July 2023

AbstractCurrently, many challenges are associated with hepatocellular carcinoma (HCC) as the failure of early diagnosis, and the lack of effective therapy. This study aimed to investigate the possible role of tuftelin 1 (TUFT 1) in the early diagnosis of HCC and evaluate the potential contribution of the TUFT 1/Ca+2/phosphinositol 3 kinase (PI3K) pathway in dantrolene sodium (Dan) therapeutic outcomes. The study was performed on two sets of rats, the staging (30 rats) and treatment sets (80 rats). HCC was induced by a single dose of diethylnitrosamine (DENA). The hepatic content of TUFT 1 protein was assayed via western blot and immunohistochemistry (IHC), while PI3K, vascular endothelial growth factor (VEGF), Cyclin D1, and matrix‐metalloproteinase‐9 (MMP‐9) contents were assessed using enzyme‐linked immunosorbent assay. Hepatic and serum calcium were measured colorimetrically. Furthermore, the nuclear proliferation marker, (Ki‐67), (Kiel [Ki] where the antibody was produced in the University Department of Pathology and the original clone number is 67)—expression was assessed by IHC. TUFT 1/Ca+2/PI3K signaling pathway was progressively activated in the 3 studied stages of HCC with subsequent upregulation of angiogenesis, cell cycle, and metastasis. More interestingly, Dan led to TUFT 1/Ca+2/PI3K pathway disruption by diminution of the hepatic contents of TUFT 1, calcium, PI3K, VEGF, Cyclin D1, and MMP‐9 in a dose‐dependent pattern. TUFT 1 can serve as a theranostic biomarker in HCC. Moreover, Dan exerted an antineoplastic effect against HCC via the interruption of TUFT 1/Ca+2/PI3K pathway.
“Crossing the invisible”
Authors: Hirai Taishi 
Published: July 2023

Key Points
Using the septal collaterals without angiographic connection during retrograde CTO PCI was associated with high collateral channel crossing rate (>80%).
Two predicators for channel crossing failure were shorter posterior descending artery (less than 2/3 of the distance to cardiac apex) and well developed non‐septal collateral.
Further studies focusing on retrograde channel selection could improve the success rate and safety of retrograde CTO PCI.