bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of motile gyrotactic microorganisms over cylindrical geometry attached Cross fluid flow mathematical model
Authors: Darvesh Adil , Sánchez‐Chero Manuel , Sánchez‐Chero José Antonio , Hernández Víctor Daniel Hijar , Guachilema Milton Doroteo Cayambe , Reyna‐Gonzalez Julissa Elizabeth 
Published: April 2023

AbstractThe aim of this study is to examine the impact of motile gyrotactic microorganisms on three‐dimensional (3D) cylindrical geometry attached to a Cross‐fluid flow mathematical model. The motion of the microorganisms is assumed to be governed by gyrotaxis, which is the tendency of the organisms to orient and swim perpendicular to fluid flow gradients. The study will incorporate the effects of the Cross fluid flow model with infinite shear rate viscosity, 3D cylinder geometry, and microorganism behavior on the resulting distribution and concentration of the organisms. For the inspection of the velocity profile of the Cross nanofluid, the inclined magnetic field is scrutinized. The temperature of Cross nanofluid and its concentration is also studied with several facts. Mass flux and heat flux values for motile microorganisms and nanoparticles are calculated through statistical graphs. Brownian motion parameter gives a lower concentration of nanoparticles, about 81.19% and 77.53% reduction is found in the concentration of motile microorganisms. These results will provide insights into the behavior of these microorganisms in natural and engineered environments, as well as their potential applications in fields such as biotechnology, environmental science, and medicine.
Forecast of policy-driven land use change and its impact on ecosystem services in China: A case study of the Yangtze River Economic Belt
Authors: Wang Wei , Wang Haofei , Zhou Xiuhui 
Published: April 2023

Abstract
Land use change is an important factor affecting the performance of ecosystem services (ESs). Therefore, understanding the impact of land use change on ESs is of great significance for promoting the coordination of regional human–land relationships. In this study, random forest and cellular automata were used to simulate and predict the characteristics of land use change in the Yangtze River Economic Belt, and diversified land use evolution patterns were formed in combination with China's strategic development needs. The effects of habitat suitability on ESs were analyzed by using a multiscenario land use change model. The results demonstrated that the driving factors selected in this article had a good induction effect on the law of land use evolution, and the simulated land use change had high credibility. Under the mode of ecological protection and cultivated land protection, the expansion of construction land was greatly affected and was not conducive to social and economic development. Under the natural evolution mode, farmland was greatly encroached upon, and food security was greatly threatened. The regional coordination model had relative advantages, and all kinds of land use needs were met to a certain extent. The water production function of ESs was strong, but the carbon storage function was weak. The relationship between the habitat suitability index and ES changes under land use change revealed that there were significant differences in ES changes caused by ecological quality changes in mountainous and plain areas. This study provides a reference for promoting social and economic development and ecosystem integrity. Integr Environ Assess Manag 2023;19:1473–1484. © 2023 SETAC
Survey‐based evaluation of national practices for postgraduate year one pharmacy resident emergency response training
Authors: Cycz Clare , Philips Eli , Edmonds Nicholas , Malacaria Justin , Wong Adrian 
Published: April 2023

AbstractIntroductionMedical emergency response teams optimally involve interdisciplinary expertise, including pharmacists. A pharmacist may make therapy recommendations, prepare medications, and act as a drug information resource, which are important skills for a postgraduate year one pharmacy resident (PGY1) to develop. Limited data exist evaluating current national practices for PGY1 emergency response.ObjectivesThe purpose of this study was to describe national practices for PGY1 emergency response. These data may help PGY1 programs identify potential best practices for self‐improvement.MethodsAn anonymous survey was developed to describe PGY1 emergency response within the United States and electronically distributed to PGY1 residency program directors. The questionnaire included general demographic information along with questions involving pharmacist and pharmacy resident emergency response and training within their institution. A univariate analysis was performed to evaluate potential predictors of survey respondent confidence in PGY1 independent emergency response by the end of the residency year.ResultsA total of 178 completed responses were obtained (response rate: 33.0%). The majority of respondents had both pharmacist and PGY1 response at their institution, with response to cardiopulmonary arrest being the most common. Of the 36 programs that did not have pharmacy resident involvement, the most common reason was due to lack of pharmacy response at their institution (61.1%). The majority of programs (68.3%) were confident in the ability for a PGY1 to independently respond by the end of their residency year. Only the number of emergency response by the end of the residency year was a predictor in their confidence of PGY1 independent response (p = 0.002).ConclusionThe majority of PGY1 programs had both pharmacist and pharmacy resident response to medical emergencies. The results of this survey may help PGY1 programs identify potential areas of improvement and help prospective residency candidates identify program characteristics that may best prepare them for emergency response.
The role of a pharmacy administration and leadership rotation within postgraduate year two critical care residency training
Authors: Pandya Komal , Wiegand Ali , Behal Michael , Dempsey Jackie , Olney Bill , Flynn Jeremy , Flannery Alexander H. , Ruf Kathryn 
Published: April 2023

AbstractThe job of a critical care pharmacy specialist has evolved to include quality improvement and administrative tasks. As such, the American Society of Health‐System Pharmacists (ASHP) highlights specific goals and objectives to ensure post‐graduate year two (PGY2) critical care residents are sufficiently trained to perform these tasks. The PGY2 critical care pharmacy residency leadership at the University of Kentucky sought to develop a 4‐week learning experience entitled, “Critical Care Administration/Medication Use Quality & Outcomes,” as a unique rotation to capture these requirements and activities. The focus of this commentary is to serve as a guide for other residency programs to develop such a rotation, highlight resulting resident contributions to the department, describe perceived benefits of this rotation for residents, and highlight how this rotation impacted graduated residents' early years as practitioners. This learning experience is pivotal to providing a more balanced view of the entire medication use process and the healthcare ecosystem during a specialty residency. PGY2 critical care residents can gain valuable experiences away from the bedside that better prepare them for future tasks in addition to patient care that will be expected of them as clinical pharmacists.
DNA interactive property of poly‐L‐lysine induces apoptosis in MCF‐7 cells through DNA interaction
Authors: Mukherjee Avinaba , Debnath Souvik , Bhowmik Arijit , Biswas Souradeep 
Published: April 2023

AbstractPoly‐L‐lysine (PLL) is known to be an encapsulating agent in drug formulation and delivery. PLL also has apoptotic and antiproliferative activities that enable blocking of the tumorigenesis process. However, the dose‐selective activities of PLL in exerting apoptosis against cancer are unclear. Therefore, this study has been designed to explore the potential role and dose of PLL in apoptosis, if any. For this, PLL was administered at several doses in cancer cell lines and was found to be more potent against MCF‐7 cells. PLL causes mitochondria‐mediated apoptotic death through the upregulation of cleaved caspase‐3. To investigate the mechanism responsible for this activity, we have analyzed if PLL could have the DNA interactive property or not. For this, molecular docking analysis was carried out to prove whether it has the property to bind with DNA or not. Studies have revealed that PLL is a potent DNA binder and it probably performs such apoptotic activities through the binding of cellular DNA early in an exposure. Simultaneous upregulation of both ROS‐mediated stress and also in key protein expressions like γ‐H2AX could also help us to confirm that PLL induces apoptosis through DNA interaction. This finding leads us to believe that PLL could play an interfering role with other chemotherapeutic compounds when used as a drug‐coating material as it exerts an apoptotic effect on cancer cells, which should be avoided by using a much lower concentration.
Kinetic and equilibrium analysis of peracetic acid formation at 1753 cm−1 mid‐infrared absorption peak using facile attenuated total reflection Fourier transform Infrared technique
Authors: Fu Cheng‐Hsin , Chen Guan‐Yu , Lin Yueh‐Hsin , Lin Cheng‐Huang , Muthiah Balaganesh , Kasai Toshio , Morita Kinichi , Mito Hiroyuki , Espulgar Wilfred , Santos Gil Nonato , Yu Derrick Ethelbhert 
Published: April 2023

AbstractIntroductionPeracetic acid (PAA) is a highly effective disinfectant against a wide range of viruses and bacteria. Its versatility, cost‐effectiveness, and ability to quickly decontaminate large areas make it an ideal choice. PAA is also environmentally friendly and safe, as it does not produce any harmful by‐products. However, to ensure its efficacy, it is crucial to maintain the optimal concentration of PAA in the solution.ObjectiveThe objective of the study is to investigate the use of attenuated total reflection Fourier transform infrared (ATR‐FTIR) spectroscopy as a method for quantifying the concentration of peracetic acid (PAA), which comes in quaternary equilibrium mixture in commercial formulation. The study also aims to determine the rate constants and equilibrium constant for the production of PAA in various conditions, including the presence of catalyst and stabilizer.MethodsThe spectra of all chemicals in PAA solution obtained in FT‐IR Spectrometer were compared to identify the characteristic peaks of PAA, which were then computed using normal mode analysis at B3LYP/6‐31G(d) level by Gaussian 09. The ATR‐FTIR was used to measure time‐dependent PAA signals until they reached equilibrium in three different conditions: (1) Acetic acid (10 to 17.4 M) and hydrogen peroxide (5 M), (2) with sulfuric acid as catalyst, and (3) with phosphoric acid as stabilizer. The collected data was analyzed through regression analysis, in which curves and rate law formulas were fitted to obtain the rate constants for peracetic acid synthesis and hydrolysis.ResultsThis study shows that ATR‐FTIR spectroscopy can detect and quantify peracetic acid with a characteristic peak at 1753 cm−1. The proposed method is applicable to all peracetic acid solutions, including those with stabilizers and catalysts. The ATR‐FTIR method offers advantages such as short detection time, simple operation, small sampling volume, and accurate measurement. Moreover, the accuracy of this quantitative method is confirmed by the fact that the reaction rate constants deduced from the fitted curves are more consistent with the actual reaction rate constants than those of the reference data based on KI titration method.
Blood glucose trends in glycogen storage disease type Ia: A cross‐sectional study
Authors: Fukuda Tokiko , Ito Tetsuya , Hamazaki Takashi , Inui Ayano , Ishige Mika , Kagawa Reiko , Sakai Norio , Watanabe Yoriko , Kobayashi Hironori , Wasaki Yosuke , Taura Junki , Imamura Yuki , Tsukiuda Tsutomu , Nakamura Kimitoshi 
Published: April 2023

AbstractBackgroundGlycogen storage disease type Ia (GSDIa) is caused by biallelic pathogenic variants in the glucose‐6‐phosphatase gene (G6PC) and mainly characterized by hypoglycemia, hepatomegaly, and renal insufficiency. Although its symptoms are reportedly mild in patients carrying the G6PC c.648G>T variant, the predominant variant in Japanese patients, details remain unclear. Therefore, we examined continuous glucose monitoring (CGM) data and daily nutritional intake to clarify their associations in Japanese patients with GSDIa with G6PC c.648G>T.MethodsThis cross‐sectional study enrolled 32 patients across 10 hospitals. CGM was performed for 14 days, and nutritional intake was recorded using electronic diaries. Patients were divided according to genotype (homozygous/compound heterozygous) and age. The durations of biochemical hypoglycemia and corresponding nutritional intake were analyzed. Multiple regression analysis was performed to identify factors associated with the duration of biochemical hypoglycemia.ResultsData were analyzed for 30 patients. The mean daily duration of hypoglycemia (<4.0 mmol/L) in the homozygous group increased with age (2–11 years [N = 8]: 79.8 min; 12–18 years [5]: 84.8 min; ≥19 years [10]: 131.5 min). No severe hypoglycemic symptoms were recorded in the patients' diaries. The mean frequency of snack intake was approximately three times greater in patients aged 2–11 years (7.1 times/day) than in those aged 12–18 years (1.9 times/day) or ≥19 years (2.2 times/day). Total cholesterol and lactate were independently associated with the duration of biochemical hypoglycemia.ConclusionAlthough nutritional therapy prevents severe hypoglycemia in patients with GSDIa with G6PC c.648G>T, patients often experience asymptomatic hypoglycemia.
急性膵炎後の被包化壊死増大に伴い脾梗塞・胃壁虚血に陥り外科手術を要した1例(Acute pancreatitis and enlarged area of walled–off necrosis followed by infarction of the spleen and ischemia of the gastric wall requiring surgery: case report)
Authors: みなみ 石田 , 麻衣 稲田 , 久晶 加藤 , 彰敏 齋藤 , 陽永 千葉 , 淳一 神原 , 眞治 稲田 
Published: April 2023

要旨　症例は40歳の男性。基礎疾患に高トリグリセリド血症があり，急性膵炎を繰り返していた。約9か月前に壊死性膵炎を発症して膵尾部と胃脾間，結腸間膜に被包化壊死を合併，以降定期的にCT画像検査による経過観察を行っていた。今回左側腹部痛を主訴に来院し，腹部CT検査において胃脾間，膵尾部に各々44mm，43mmの被包化壊死を認め，いずれも2か月前の検査時より被包化壊死の増大を認めた。またそれぞれの被包化壊死に隣接して胃穹窿部の浮腫性変化と脾動脈閉塞，脾梗塞を認めた。ヘパリン・抗菌薬・鎮痛薬による保存的治療から開始したが，発熱が継続し，炎症反応の改善も得られず，入院第4病日のCT検査では脾梗塞の状況に改善がなく，一方で被包化壊死に接する胃壁全層の虚血所見が明らかとなったため，保存的治療を断念し，緊急開腹術での膵尾部切除・脾摘出・胃部分切除術を施行した。病理所見では被包化壊死と脾動脈との間には炎症性細胞の浸潤を認め，脾動脈内腔には白色血栓を認めた。胃壁漿膜側は被包化壊死に伴う炎症所見や周囲血管内の血栓形成を認めた。被包化壊死の自然史は明確ではなく，保存的治療においては，症状や画像所見を丁寧に評価して外科的治療介入の時期を見逃さないことが重要である。
VV–ECMO導入時に生じた右鎖骨下動脈–内頚静脈瘻に対してVIABAHN® ステントグラフトで修復した1例(A case of a right subclavian artery–internal jugular vein fistula that occurred at the time of VV–ECMO cannulation and was treated with VIABAHN® stent graft)
Authors: 源 鈴木 , 洋征 川浦 , 秀 人見 , 昌士 五木田 , 勝伸 勅使河原 , 茂正 田口 , 和也 清田 
Published: April 2023

要旨veno–veous extracorporeal membrane oxygenation（VV–ECMO）導入時に生じた右鎖骨下動脈–内頚静脈瘻（SCA–IJV fistula）に対してVIABAHN®を用いて血管修復を行った1例を経験したため報告する。症例は67歳男性。肺胞蛋白症に対してVV–ECMO補助下で全肺洗浄を行う目的で入院し，術前に右内頚静脈への送血管の挿入を試みた。ガイドワイヤーが下大静脈まで挿入されていることを確認した後，ダイレーターによる拡張を行ったが，抵抗があったため処置を中断した。中断後の造影CT検査で右SCA–IJV fistulaを認めたため，同日に右鎖骨下動脈損傷部にVIABAHN®を留置して修復を行った。第3，7病日にそれぞれ右，左全肺洗浄を実施し，第15病日に退院した。VV–ECMO導入時の合併症としての右SCA–IJV fistulaは稀である。ガイドワイヤーが適切に挿入されていてもダイレーターで血管壁を損傷する場合があり，リアルタイムでダイレーターやカテーテル先端を確認する必要があると考えられた。本症例のように呼吸不全の患者や，呼吸予備能の低下した患者において，SCA–IJV fistulaが生じた場合には，外科的修復は選択しにくく，低侵襲な血管内治療が有用であった。
Effect of polysaccharides on the rheological behaviour of soy–wheat protein aggregation and conformational changes during high‐moisture extrusion
Authors: Wang Fengqiujie , Lian Wentao , Gu Xuelian , Zhang Haojia , Gao Yang , Lü Mingshou , Zhu Ying , Huang Yuyang , Sun Ying , Zhu Xiuqing 
Published: April 2023

AbstractBACKGROUNDDue to the extrusion black box effect, polysaccharides determine the formation of meat‐like fibrous structures by modulating the flow behaviour and structural changes of plant proteins under high‐moisture extrusion conditions. However, there is limited knowledge on the mechanism of resolution. This study simulated the rheological properties of soy protein–wheat protein under 57% moisture conditions with addition of 4% sodium alginate (SA), 2% xanthan gum (XG), and 2% maltodextrin (MD). The effect of these polysaccharides on the aggregation behaviour and conformation of raw protein during high‐moisture extrusion was investigated.RESULTSIt was revealed that the three polysaccharides were effective in increasing the interaction between proteins and between proteins and water. Among them, 4% SA elicited a significantly stronger storage modulus (gelation behaviour) compared to the control. Analysis of different zones of extrudates by protein electrophoresis, particle size, and turbidity showed that SA‐4% was able to form more high molecular protein aggregates (> 245 kDa) and promoted crosslinking of low molecular subunits (< 48 kDa), resulting in moderately sized protein aggregated particles. Fluorescence and ultraviolet spectra showed the transformation of protein tertiary structures in different extrusion zones, confirming that the key extrusion zone for protein conformational transformation by polysaccharides is the die–cooling zone. Furthermore, stretching of polypeptide chains and accelerated protein rearrangement facilitated the formation of more fibrillar structures.CONCLUSIONTheoretical support for polysaccharide modulation of plant protein quality in high moisture extruded products is provided by this study. © 2023 Society of Chemical Industry.
Why Do Candidates Forgo Cochlear Implantation?
Authors: Sturm Joshua J. , Brandner Gabriel , Ma Cheng , Schvartz‐Leyzac Kara C. , Dubno Judy R. , McRackan Theodore R. 
Published: April 2023

ObjectiveIdentify barriers and facilitating factors in cochlear implant (CI) utilization by comparing functional measures between CI candidates who undergo or forgo implantation.MethodsForty‐three participants were separated into two groups: (1) 28 participants who underwent CI and (2) 15 participants who elected not to proceed with CI despite meeting eligibility criteria (no‐CI). Prior to implantation, all participants completed the CI Quality of Life (CIQOL)‐35 Profile and CIQOL‐Expectations instrument. They were also surveyed on factors contributing to their decision to either undergo or forgo CI. Word and speech recognition were determined using the Consonant‐Nucleus‐Consonant (CNC) and the AzBio tests, respectively.ResultsCIQOL‐Expectations scores were indistinguishable between groups, but there were substantial differences in baseline CIQOL‐35 Profile scores. Compared to the CI group, the no‐CI group exhibited higher pre‐CI scores in the Emotional (Cohen's d [95% CI] = 0.8 [0.1, 1.5]) and Entertainment (Cohen's d [95% CI] = 0.8 [0.1, 1.5]) domains. Survey data revealed that the most commonly reported barriers to pursuing CI in the no‐CI cohort were fear of surgical complications (85%), cost associated with implantation (85%), and perception that hearing was not poor enough for CI surgery (85%).Conclusions and RelevanceThe results of this study indicate that functional outcome expectations are similar between candidates who elect to receive or forgo CI, yet those who forgo CI have higher baseline CI‐specific QOL abilities.Level of Evidence4 Laryngoscope, 133:3548–3553, 2023
How to improve scientific peer review: Four schools of thought
Authors: Waltman Ludo , Kaltenbrunner Wolfgang , Pinfield Stephen , Woods Helen Buckley 
Published: April 2023

AbstractPeer review plays an essential role as one of the cornerstones of the scholarly publishing system. There are many initiatives that aim to improve the way in which peer review is organized, resulting in a highly complex landscape of innovation in peer review. Different initiatives are based on different views on the most urgent challenges faced by the peer review system, leading to a diversity of perspectives on how the system can be improved. To provide a more systematic understanding of the landscape of innovation in peer review, we suggest that the landscape is shaped by four schools of thought: The Quality & Reproducibility school, the Democracy & Transparency school, the Equity & Inclusion school, and the Efficiency & Incentives school. Each school has a different view on the key problems of the peer review system and the innovations necessary to address these problems. The schools partly complement each other, but we argue that there are also important tensions between them. We hope that the four schools of thought offer a useful framework to facilitate conversations about the future development of the peer review system.
Bifid Intratemporal facial nerves in an adult without other congenital anomalies
Authors: White Stephen F. , Tillett Natasha D. , Ogunsusi Monica T. , Yawn Robert J. 
Published: April 2023

AbstractObjectiveTo describe a case of bifid intratemporal facial nerves without associated middle or inner ear abnormalities encountered on computed tomography (CT) imaging during preoperative preparation for unilateral cochlear implant placement in an adult male with profound sensorineural hearing loss (SNHL).MethodsA rare case of bilateral bifid intratemporal facial nerves in an adult male is presented. The finding's impact on approach to safe cochlear implantation is discussed.ResultsBifurcation of the intratemporal facial nerve is rarely seen and is usually associated with congenital middle or inner ear anomalies. A unique case of bilateral bifid intratemporal facial nerves without other middle or inner ear abnormalities was encountered incidentally on CT imaging during preparation for unilateral cochlear implant placement in an adult male with profound SNHL. The nerve was bifid along the mastoid segment with a nerve branch traversing through the facial recess precluding safe traditional approach to cochlear implant placement. Accessory stylomastoid foramina were noted bilaterally. Unilateral subtotal petrosectomy was performed with successful implantation and excellent hearing outcome. No additional clinical or radiographic otologic abnormalities were noted.ConclusionAbnormal bifurcation of the facial nerve may occur in adults without other middle or inner ear anomalies. This case highlights the importance of independent imaging review by the surgeon and vigilance to potential rare anatomic aberrations of the facial nerve during cochlear implantation.Level of EvidenceIV