bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selection of Knees With Subsequent Cartilage Thickness Loss Based on Magnetic Resonance Imaging Semiquantitative Grading: Data From the Osteoarthritis Initiative Foundation for the National Institutes of Health Biomarker Cohort
Authors: Wirth Wolfgang , Maschek Susanne , Wisser Anna , Guermazi Ali , Hunter David J. , Kwoh C. Kent , Nevitt Michael C. , Eckstein Felix , Roemer Frank W. 
Published: December 2022

ObjectiveTo investigate which magnetic resonance imaging (MRI)–based articular pathologies are predictive of subsequent medial femorotibial compartment quantitative cartilage thickness loss and therefore suitable for enrichment of clinical trials with participants showing a high likelihood for structural progression.MethodsSemiquantitative MRI Osteoarthritis Knee Score (MOAKS) assessments at baseline and quantitative cartilage thickness measurements at baseline and year‐2 follow‐up were performed in 599 participants (age 62 years; body mass index 31 kg/m2; 59% female) from the Osteoarthritis Initiative–based Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium. Knees were classified as medial femorotibial compartment (MFTC) progressors or nonprogressors based on MFTC cartilage thickness change (smallest detectable change threshold −111 μm). Logistic regression was used to investigate the association between baseline presence and severity of MFTC MOAKS pathologies with subsequent MFTC progression. The standardized response mean (SRM) was computed to estimate the sensitivity to change that can be achieved when selecting knees based on MOAKS pathologies.ResultsPresence of MFTC MOAKS cartilage damage (odds ratio [OR] 2.77 [95% confidence interval (95% CI) 1.76, 4.36]), MFTC bone marrow lesions (OR 2.69 [95% CI 1.89, 3.83]), medial meniscus extrusion or damage (OR 2.21 [95% CI 1.37, 3.55]), as well as MOAKS severity subscales for cartilage and meniscus damage were associated with subsequent progression. The SRM was greater in knees with than in knees without the presence of these pathologies and was associated with the severity of those pathologies.ConclusionMRI‐based grading of articular pathologies makes it possible to specifically select progressor knees suitable for inclusion in clinical trials but also to identify knees in which treatment is not indicated (e.g., knees without cartilage damage despite presence of radiographic osteoarthritis).
Associations Between Patterns of Esophageal Dysmotility and Extra‐Intestinal Features in Patients With Systemic Sclerosis
Authors: Tucker Ana E. , Perin Jamie , Volkmann Elizabeth R. , Abdi Tsion , Shah Ami A. , Pandolfino John , Silver Richard M. , McMahan Zsuzsanna H. 
Published: December 2022

ObjectiveThe gastrointestinal tract is commonly involved in patients with systemic sclerosis (SSc) with varied manifestations. As our understanding of SSc gastrointestinal disease pathogenesis and risk stratification is limited, we sought to investigate whether patterns of esophageal dysfunction associate with specific clinical phenotypes in SSc.MethodsPatients enrolled in the Johns Hopkins Scleroderma Center Research Registry who completed high‐resolution esophageal manometry (HREM) studies as part of their clinical care between 2011 and 2020 were identified. Associations between esophageal abnormalities on HREM (absent contractility [AC], ineffective esophageal motility [IEM], hypotensive lower esophageal sphincter [hypoLES]) and patient demographic information, clinical characteristics, and autoantibody profiles were examined.ResultsNinety‐five patients with SSc had HREM data. Sixty‐five patients (68.4%) had AC (37 patients with only AC, 28 patients with AC and a hypoLES), 9 patients (9.5%) had IEM, and 11 patients (11.6%) had normal studies. AC was significantly associated with diffuse cutaneous disease (38.5% versus 10.0%; P < 0.01), more severe Raynaud's phenomenon, including digital pits, ulcers, or gangrene (56.9% versus 30.0%; P = 0.02), and reduced median diffusing capacity of lung for carbon monoxide (50.6% versus 72.2%; P = 0.03). AC was observed in most of the patients who died (13 of 14; P = 0.06). These findings were not seen in patients with IEM.ConclusionAmong patients with SSc, AC is associated with a significantly more severe clinical phenotype. IEM may associate with a milder phenotype. Further studies are needed to evaluate AC, IEM, and their clinical impact relative to the timing of other end‐organ complications in SSc.
A Breathable, Passive‐Cooling, Non‐Inflammatory, and Biodegradable Aerogel Electronic Skin for Wearable Physical‐Electrophysiological‐Chemical Analysis
Authors: Zhu Yangzhi , Haghniaz Reihaneh , Hartel Martin C. , Guan Shenghan , Bahari Jamal , Li Zijie , Baidya Avijit , Cao Ke , Gao Xiaoxiang , Li Jinghang , Wu Zhuohong , Cheng Xuanbing , Li Bingbing , Emaminejad Sam , Weiss Paul S. , Khademhosseini Ali 
Published: December 2022

AbstractReal‐time monitoring of human health can be significantly improved by designing novel electronic skin (E‐skin) platforms that mimic the characteristics and sensitivity of human skin. A high‐quality E‐skin platform that can simultaneously monitor multiple physiological and metabolic biomarkers without introducing skin discomfort or irritation is an unmet medical need. Conventional E‐skins are either monofunctional or made from elastomeric films that do not include key synergistic features of natural skin, such as multi‐sensing, breathability, and thermal management capabilities in a single patch. Herein, a biocompatible and biodegradable E‐skin patch based on flexible gelatin methacryloyl aerogel (FGA) for non‐invasive and continuous monitoring of multiple biomarkers of interest is engineered and demonstrated. Taking advantage of cryogenic temperature treatment and slow polymerization, FGA is fabricated with a highly interconnected porous structure that displays good flexibility, passive‐cooling capabilities, and ultra‐lightweight properties that make it comfortable to wear for long periods of time. It also provides numerous permeable capillary channels for thermal‐moisture transfer, ensuring its excellent breathability. Therefore, the engineered FGA‐based E‐skin can simultaneously monitor body temperature, hydration, and biopotentials via electrophysiological sensors and detect glucose, lactate, and alcohol levels via electrochemical sensors. This work offers a previously unexplored materials strategy for next‐generation E‐skin platforms with superior practicality.
Acid‐Ionizable Iron Nanoadjuvant Augments STING Activation for Personalized Vaccination Immunotherapy of Cancer
Authors: Chen Fangmin , Li Tianliang , Zhang Huijuan , Saeed Madiha , Liu Xiaoying , Huang Lujia , Wang Xiyuan , Gao Jing , Hou Bo , Lai Yi , Ding Chunyong , Xu Zhiai , Xie Zuoquan , Luo Min , Yu Haijun 
Published: December 2022

AbstractThe critical challenge for cancer vaccine‐induced T‐cell immunity is the sustained activation of antigen cross‐presentation in antigen‐presenting cells (APCs) with innate immune stimulation. In this study, it is first discovered that the clinically used magnetic contrast agents, iron oxide nanoparticles (IONPs), markedly augment the type‐I interferon (IFN‐I) production profile of the stimulator of interferon genes (STING) agonist MSA‐2 and achieve a 16‐fold dosage‐sparing effect in the human STING haplotype. Acid‐ionizable copolymers are coassembled with IONPs and MSA‐2 into iron nanoadjuvants to concentrate STING activation in the draining lymph nodes. The top candidate iron nanoadjuvant (PEIM) efficiently delivers the model antigen ovalbumin (OVA) to CD169+ APCs and facilitates antigen cross‐presentation to elicit a 55‐fold greater frequency of antigen‐specific CD8+ cytotoxic T‐lymphocyte response than soluble antigen. PEIM@OVA nanovaccine immunization induces potent and durable antitumor immunity to prevent tumor lung metastasis and eliminate established tumors. Moreover, PEIM nanoadjuvant is applicable to deliver autologous tumor antigen and synergizes with immune checkpoint blockade therapy for prevention of postoperative tumor recurrence and distant metastasis in B16‐OVA melanoma and MC38 colorectal tumor models. The acid‐ionizable iron nanoadjuvant offers a generalizable and readily translatable strategy to augment STING cascade activation and antigen cross‐presentation for personalized cancer vaccination immunotherapy.
Polymer Electrolyte/Sulfur Double‐Shelled Anisotropic Reduced Graphene Oxide Lamellar Scaffold Enables Stable and High‐Loading Cathode for Quasi‐Solid‐State Lithium‐Sulfur Batteries
Authors: Shin Hyun Jung , Park Sung‐Woo , Park Sangbaek , Kim Dong‐Wan 
Published: December 2022

AbstractLithium‐sulfur batteries (LSBs) can replace lithium‐ion batteries by delivering a higher specific capacity. However, the areal capacity of current LSBs is low because the intrinsic limitations of sulfur make achieving a high sulfur loading difficult. Herein, the authors report vertically aligned reduced graphene oxide (rGO) with sulfur and poly(ethylene oxide)‐based polymer electrolyte double‐shell layers (VRG@S@PPE) as a high‐loading sulfur cathode. The addition of vapor‐grown carbon fiber (VGCF) into rGO is the key to success, as it allows for gas evacuation from internal nano/micropores without structural collapse, enabling perfect double‐shell layer contact. Owing to the anisotropic rGO lamellar structure that enables straightforward ion/electron transport and provides numerous active sites, sulfur‐infiltrated rGO reinforced via VGCF (VRG@S) exhibits a high capacity of 998 mAh g−1 after 100 cycles at 0.1 C under high sulfur loading (6 mg cm−2). Interestingly, an additional polymer electrolyte layer further increases the cycle retention (1005 and 718 mAh g−1 after 100 cycles at 0.1 and 1 C, respectively), because intimate contact between the solid polymer electrolyte and sulfur could suppress the loss of sulfur due to lithium polysulfide (LPS) shuttling or volume change during lithiation/delithiation. Therefore, it is possible to realize safe and stable quasi‐solid‐state LSBs with high sulfur loading.
Methotrexate for recurrent chronic rhinosinusitis with nasal polyps: A randomized, controlled, phase 2 clinical trial
Authors: Cakir Cetin Asli , Tuncok Yesim , Keskinoglu Pembe , Arici Mualla Aylin , Onen Fatos , Ecevit Mustafa Cenk 
Published: December 2022

AbstractObjectiveThis randomized, controlled, open‐label, phase 2 clinical trial aimed to assess the efficacy and safety of low‐dose methotrexate as maintenance therapy for recurrent postoperative chronic rhinosinusitis with nasal polyps (CRSwNPs).MethodsForty‐one patients with CRSwNPs who experienced postoperative polyp recurrence(s) were randomly divided into three groups to receive one of the following treatments for 8 weeks: daily intranasal mometasone furoate monohydrate 200 mcg (control [intranasal corticosteroids (INCS)] arm, n = 13]); daily per oral methylprednisolone 8 mg (oral corticosteroids [OCS] arm, n = 14); and once weekly per oral 10 mg methotrexate (MTX arm, n = 14). All patients were assessed at three clinical visits according to the Lund‐Kennedy endoscopic grading system (LKES), visual analog scale (VAS), Turkish version of the Sinonasal Outcome Test‐22 (SNOT‐22), peak nasal inspiratory flow (PNIF), butanol olfactory threshold test (BuOT), serum total IgE level, presence of peripheral eosinophilia, serum biochemical assays, and adverse events.ResultsAll efficacy outcome measures significantly improved in all three groups, except for the nonrecovery of peripheral eosinophilia in the INCS group. There was no significant difference among the groups in terms of LKES scores. Scores for the Turkish version of the SNOT‐22, PNIF, BuOT, and serum IgE levels were also similar among the groups. However, total VAS scores recovered significantly better in the INCS group than in the MTX group. Serum biochemical assays remained normal in all groups. Adverse events were minor and observed only in the OCS group.ConclusionLow‐dose MTX was a safe and effective maintenance therapy for patients with recurrent postoperative CRSwNPs.
Covalent Organic Frameworks Containing Dual O2 Reduction Centers for Overall Photosynthetic Hydrogen Peroxide Production
Authors: Chen Dan , Chen Weiben , Wu Yuting , Wang Lei , Wu Xiaojun , Xu Hangxun , Chen Long 
Published: December 2022

AbstractCovalent organic frameworks (COFs) are highly desirable for achieving high‐efficiency overall photosynthesis of hydrogen peroxide (H2O2) via molecular design. However, precise construction of COFs toward overall photosynthetic H2O2 remains a great challenge. Herein, we report the crystalline s‐heptazine‐based COFs (HEP‐TAPT‐COF and HEP‐TAPB‐COF) with separated redox centers for efficient H2O2 production from O2 and pure water. The spatially and orderly separated active sites in HEP‐COFs can efficiently promote charge separation and enhance photocatalytic H2O2 production. Compared with HEP‐TAPB‐COF, HEP‐TAPT‐COF exhibits higher H2O2 production efficiency for integrating dual O2 reduction active centers of s‐heptazine and triazine moieties. Accordingly, HEP‐TAPT‐COF bearing dual O2 reduction centers exhibits a remarkable solar‐to‐chemical energy efficiency of 0.65 % with a high apparent quantum efficiency of 15.35 % at 420 nm, surpassing previously reported COF‐based photocatalysts.
GC/MS and LC/MS Phytochemical Analysis of Vigna unguiculata L. Walp Pod
Authors: Mahavirsing Dinore Jaysing , Shivaji Patil Harshal , Farooqui Samreen , Pradhan Vidya , Farooqui Mazahar 
Published: December 2022

AbstractVigna unguiculata (L. Walp) or Cowpea pod methanolic extracts phytochemical analysis, total phenolic content (TPC), and secondary metabolite profiling were determined using gas chromatography‐mass spectrometry (GC/MS) and liquid chromatography‐mass spectrometry (LC/MS) analysis. GC/MS analysis revealed twenty compounds in the extract, while LC/MS analysis identified twenty‐four compounds. GC/MS chromatogram analysis suggested the presence of opioid α‐N‐Normethadol a major constituent found in methanolic extract and fatty acid esters carotenoid is found second major constituent. LC/MS chromatogram and the mass spectral analysis demonstrated the presence of flavonoids, carotenoids, and alkaloids as major phytochemicals. We investigated the antibacterial, anti‐fungal, and anti‐oxidant activity of pod methanolic extract. The extract was found equally effective against E. coli, S. pyogenes, and P. aeruginosa with MIC 100 μg/mL similar to the standard Ampicillin (MIC 100 μg/mL). C. albicans were found to be most susceptible to Vign unguiculata pods methanolic extract with a MIC of 250 μg/mL. The pod extract showed significant DPPH scavenging activity (IC50=78.38±0.15) which suggests its antioxidant potential.
PGAM4 silencing inhibited glycolysis and chemoresistance to temozolomide in glioma cells
Authors: Lu Bin , Nie Xiao‐Hu , Yin Rui , Ding Peng , Su Zhong‐Zhou , Qiu Sheng , Qian Ya‐Fang 
Published: December 2022

AbstractGliomas account for about 80% of malignant brain tumors. The incidence of a new brain tumor is 6.4 per 100,000 persons per year with an overall 5‐year survival rate of 33.4%. Regardless of the great advances that have been made in recent years, the causes and pathogenesis of glioma remain unclear. Here we study how phosphoglycerate mutase 4 (PGAM4) contributes to glioma. Using a variety of methods to examine glioma cell viability, proliferation, apoptosis, glycolysis, as well as ChIP coanalysis with modified histone H3, we showed that PGAM4 was significantly upregulated in patients with glioma and associated with poor survival. Silencing PGAM4 attenuated cell viability, proliferation, and glycolysis in T98G cells and suppressed tumor growth in vivo, while overexpressing PGAM4 promoted cell viability, proliferation, and glycolysis in U251 cells via regulating glycolysis pathway. Study also revealed that PGAM4 was regulated by EP300‐mediated modifications of H3K27ac. PGAM4 silencing inhibited cell viability and proliferation, suppressed tumor growth, and decreased chemoresistance to temozolomide in glioma cells through suppressing glycolysis.
Novel case of laparoscopically resected gastric adenocarcinoma concurrent with lanthanum deposition
Authors: Hirose Kosuke , Saito Shunichi , Oshiro Yumi , Minami Kazuhito , Ikegami Koji , Kurahara Koichi , Honbo Takuya , Sadanaga Noriaki , Matsuura Hiroshi 
Published: December 2022

AbstractA 73‐year‐old man taking lanthanum carbonate for hemodialysis showed progressing gastric mucosal changes with lanthanum deposition. Regular examination revealed concurrent gastric carcinoma. The extent and depth of its invasion were ambiguous because of the surrounding lanthanum deposition. Furthermore, there could be other potent carcinomas, and curative laparoscopic gastrectomy was performed.
Phrenic nerve schwannoma presenting as an asymptomatic neck mass
Authors: Chan Kimberly , Keane Allison , Aynardi Jason , Choi Karen Y. 
Published: December 2022

AbstractPhrenic nerve schwannomas of the head and neck are exceedingly rare pathologies that can present as an asymptomatic neck mass. Surgery is the definitive treatment, and a conservative surgical approach is preferred if a benign pathology is suspected.
Multiple tracheobronchial diverticula in a post‐TB patient: A case report
Authors: Timilsina Bibek , Pangeni Raju Prasad , Khadka Sulochana , Regmi Pradeep Raj , Dhakal Binaya 
Published: December 2022

AbstractThe presence of multiple tracheal and bronchial diverticula is a rare condition. We present a case of a 22‐years old non‐smoker male with a history of pulmonary tuberculosis, having multiple tracheal and bronchial diverticula along with other common sequelae such as stenosed and collapsed upper lobe bronchi.
Long‐term survival of a patient with lung cancer treated with pembrolizumab after recurrent cardiac tamponade
Authors: Uchida Tsuyoshi , Matsubara Hirochika , Muto Mamoru , Sasanuma Harunobu , Sugimura Saya , Onuki Yuichiro , Nakajima Hiroyuki 
Published: December 2022

AbstractA 69‐year‐old man with non‐small cell lung cancer presenting with pericardial effusion and rapid progression of dyspnea achieved long‐term disease stabilization after radiation therapy and immunotherapy. This case shows that pembrolizumab may improve prognosis in advanced lung cancer, even when complicated by cardiac tamponade.
Cardiac arrest during a diving session: A case report and differential diagnosis
Authors: Ippolito Mariachiara , Tubiolo Martina , Falletta Angelo , Federico Antonino , Simone Barbara , Ingoglia Giulia , Gregoretti Cesare , Raineri Santi Maurizio , Cortegiani Andrea , Giarratano Antonino 
Published: December 2022

AbstractWe report a case of out‐of‐hospital cardiac arrest occurred in a 61‐year‐old recreational female diver. After resuscitation, the patient was referred to the hospital. With data provided by witnesses and appropriate medical investigations, drowning related to a failed rebreather system was the most plausible explanation. Patient outcome was favorable.
Single Amino Acid Residues Control Potential‐Dependent Inactivation of an Inner Membrane bc‐Cytochrome**
Authors: Joshi Komal , Chan Chi H. , Levar Caleb E. , Bond Daniel R. 
Published: December 2022

AbstractDuring extracellular electron transfer, Geobacter sulfurreducens constitutively expresses the bc‐cytochrome CbcL, yet cells containing only this menaquinone oxidase fail to respire above −0.1 V vs. SHE. By identifying mutations within cbcL that permit growth at higher potentials, we provide evidence that this cytochrome is regulated by redox potential. Strains expressing only CbcLV205A, CbcLV205G, and CbcLF525Y were capable of growth with high potential electron acceptors including Fe(III) citrate, Mn(IV) oxides, and electrodes poised at +0.1 V vs. SHE. Electrochemical characterization of wild type CbcL revealed oxidative inactivation of electron transfer above −0.1 V, while CbcLV205A, CbcLV205G, and CbcLF525Y remained active. Growth yields of CbcLV205A, CbcLV205G, and CbcLF525Y were only 50 % of WT, consistent with CbcL‐dependent electron transfer conserving less energy. These data support the hypothesis that CbcL has evolved to rapidly shut off in response to redox potential, in order to divert electrons to higher yield oxidases that coexist in the Geobacter membrane.
Solvothermal Polymerization and Electrochemical Behavior of Conjugated Polyimide with High Electronic Conductivity and Low Solubility
Authors: Xue Zhihuan , Zhan Yu , Wang Shengping , Yu Jingxian 
Published: December 2022

AbstractThe polymerization of small molecules as electrode materials in lithium‐ion batteries not only reduces the solubility but also improves the surface structure and electrical conductivity. The law governing the correlations between the solvothermal temperature of polyimide (PQI) and its surface morphology and structure and electrochemical properties is investigated. The 1st and 200th discharge capacity densities for PQI‐180 with fine electrochemical performance at 100 mA g−1 are 246.6 and 178.5 mAh g−1, respectively. The rich pore structure of PQI‐180 is conducive to accelerating ion migration and reducing diffusion impedance. In addition, PQI‐180 with a uniform three‐dimensional mesh structure makes sufficient contact with the conductive agent, reducing the electron contact resistance. Unlike previously reported 3‐ or 4‐electron reactions, PQI used as an electrode material shows a 5‐electron reaction and a theoretical capacity of 319 mAh g−1 at voltages ranging from 1.5–3.0 V, and theoretical calculations and experiments explain that this result is due to a new electrochemical reaction mechanism.
Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling
Authors: George Aman , Lee Jerry , Liu James , Kim Suzie , Brooks Brian P. 
Published: December 2022

AbstractBackgroundRERE is a highly conserved transcriptional co‐regulator that is associated with a human neurodevelopmental disorder with or without anomalies of the brain, eye, or heart (NEDBEH, OMIM: 616975).ResultsWe show that the zebrafish rerea mutant (babyface) robustly recapitulates optic fissure closure defects resulting from loss of RERE function, as observed in humans. These defects result from expansion of proximal retinal optic stalk (OS) and reduced expression of some of the ventral retinal fate genes due to deregulated protein signaling. Using zebrafish and cell‐based assays, we determined that NEDBEH‐associated human RERE variants function as hypomorphs in their ability to repress shh signaling and some exhibit abnormal nuclear localization. Inhibiting shh signaling by the protein inhibitor HPI‐1 rescues coloboma, confirming our observation that coloboma in rerea mutants is indeed due to deregulation of shh signaling.ConclusionsZebrafish rerea mutants exhibit OS and optic fissure closure defects. The optic fissure closure defect was rescued by an shh signaling inhibitor, suggesting that this defect could arise due to deregulated shh signaling.