bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of Dkk 1 in Endometrial Endometrioid Carcinoma & Its Correlation with Wnt / β-catenin Signaling Pathway
Authors: Das Abhijit , Mathur Sandeep R , Kumar Sunesh , Bhatla Neerja 
Published: December 2022

Objective: Endometrial cancer is the most common form of cancer affecting female reproductive organs. Most common histologic type endometrioid carcinoma constitutes 75 to 80% of all cases. Studies on Dkk1 expression profiles and its inhibitory role in Wnt signaling pathway in genesis and development of endometrial carcinoma are very few. This study aims to investigate Dkk1 expression in endometrial carcinoma and its correlation with Wnt/β-catenin pathway. Methods: A total of 160 formalin fixed paraffin embedded samples including 50 cases each of endometrial atypical hyperplasia and endometrioid endometrial carcinoma along with 30 cases each of proliferative and secretory endometrium were included in this study. We investigated expression pattern of Dkk1, E-cadherin, β-catenin and c-myc in endometrial atypical hyperplasia and carcinoma as well as compared with that of proliferative and secretory endometrium. Immunohistochemistry and analysis were performed from July, 2018 to June, 2020. Results: We showed decreasing pattern of immunopositivity for Dkk1, E-cadherin and β-catenin from proliferative/secretory endometrium to endometrial atypical hyperplasia and endometrioid carcinoma. Increasing c-myc immunopositivity was noted from proliferative/secretory endometrium to endometrial atypical hyperplasia and endometrioid carcinoma. Moreover, decreasing Dkk1 immunopositivity was well correlated with both E-cadherin, β-catenin and c-myc immunopositivity. Conclusion: Decreasing Dkk1 positivity from benign endometrium to endometrioid carcinoma suggests a negative regulatory function of Dkk1 in endometrioid carcinoma. Dkk1 is downregulated in Wnt signaling pathway in endometrioid endometrial carcinoma. Thus, Dkk1 can show promise as a biomarker for screening endometrioid carcinoma. Future researches can study the reactivation of the Dkk1 gene that could be a valuable strategy for antagonizing Wnt signaling pathway.
Keywords: Endometrioid carcinoma, Dkk1, Wnt/β-catenin pathway, β-catenin, E-cadherin
Pigmentos naturais como alternativa a corantes e conservantes sintéticos para a indústria alimentícia animal: uma revisão
Authors: Martins Paulo Henrique Pessoa , Marinho Bruna Sthephany dos Santos , Lima Gláucia Manoella de Souza 
Published: December 2022

O Brasil é um dos maiores produtores de pecuária do mundo, com mais de 1800 milhões de cabeças de gado, 1200 milhões de suínos e 370 milhões de aves, e o segundo maior em população de cães e gatos, sendo mais de 52 milhões de cães e 22 milhões de gatos. Os corantes alimentares são aditivos com importante relevância para a indústria de rações, por melhorarem a aparência dos alimentos destinados aos animais, além de serem empregados como colorantes em algumas aves. Assim, tornando o produto mais atrativo influenciando diretamente no poder de escolha do consumidor. Porém, os componentes empregados na indústria de rações têm sido apontados como causadores de diversas doenças em todo mundo. A contraponto dos corantes artificiais, os naturais, além de tornar os alimentos mais atrativos, podem agregar vantagens aos produtos sendo relevantes, tanto para o animal, no que diz respeito à melhora de suas funções biológicas, como anticancerígenos, que para a indústria, pode associar inúmeras vantagens aos seus produtos, como agentes conservantes natural, reduzindo o número de aditivos artificiais nas rações, além de atender às questões ecológicas por serem biodegradáveis. Alguns microrganismos e plantas são industrialmente relevantes pela sua produção de pigmentos, como microrganismos do gênero Streptomyces e Aspergillus, e plantas, como do gênero Indigofera, que produzem pigmentos naturais, com diversos efeitos biológicos, podendo ser utilizada na indústria como um aditivo alimentar para desempenhar um papel bactericida, tingimento e preservação de alimentos. Diante disto, este estudo tem como objetivo fazer uma revisão bibliográfica das principais fontes de pigmentos naturais para a indústria alimentícia.
Association of non-high-density lipoprotein hypercholesterol with metabolic syndrome, diabetes and arterial hypertension in the population of 45–69 years adults
Authors: Simonova G. I. , Mustafina S. V. , Rymar O. D. , Malyutina C. K. , Sherbakova L. V. , Kashirina A. P. , Nikitin Yu. P. , Ragino Yu. I. 
Published: December 2022

Objective. To study the prevalence of non-high-density lipoprotein hypercholesterol (non-HDL–C) and the average levels of non-HDL–C in metabolic syndrome (MS), type 2 diabetes mellitus (DM2), arterial hypertension (AH) and other cardiometabolic risk factors in the Siberian population aged 45–69 years.Design and methods. The evaluation of atherogenic dyslipidemia among persons with AН, MS, T2D was based on the materials of Siberian branch of HAPIEE project in the random sample n = 9360 surveyed in 2003–2005 HAPIEE. The study program included questionnaire survey, blood pressure (BP) measurement, anthropometry, biochemical screening. The value ≥ 3,4 mmol/l was considered as hypercholesterol-non-HDL. AH was diagnosed at systolic BP levels ≥ 140 mm hg. art. or diastolic BP ≥ 90 mm hg. art. and/or taking antihypertensive drugs within the last 2 weeks. Persons with previously diagnosed AH, but with normotonia at screening in cases of taking drugs that reduce BP, were also counted as patients with AH. DM2 was diagnozed — according to WHO criteria, 1999, ADA, 2013 — at fasted plasma glucose level ≥ 7,0 mmol/l and persons with previously diagnosed DM2. MS and its components were diagnosed according to IDF criteria (2005).Results. The mean value of non-HDL cholesterol in the general population of Novosibirsk aged 45–69 were 4,7 ± 1,3 mmol/l and were higher in women than in men — 4,9 ± 1,3 mmol/l and 4,5 ± 1,2 mmol/l, (p < 0,0001). The prevalence of hypercholesterol-non-HDL in women varies from 84,7 to 94,3% — and is significantly higher than in men — 80,6 to 84,1%. The level of non-HDL cholesterol ≥ 3,4 mmol/l was observed in 86,8% of the examined, 11% — in the range of 2,6–3,39 and only 2,2% — less than 2,6 mmol/l. The average values of non-HDL–C in men and women in three cohorts (with DM2, MS and AH) were found to be the highest in DM2, lower in MS than in DM, and lower in AH than in MS and DM2. In the cohort with DM2, non-HDL–C, according to the criterion of non-HDL–C ≥ 3,4 mmol/l, was determined in 89,4% of men and 95,7% of women; in persons with MS, it was found in 92,4% of men and 95,1% of women, with AH — in 85,2% of men and 92,5% of women of the Siberian population aged 45–69 years. The frequencies of AH, MS and DM2 in the 5th quintile of the distribution of non-HDL–C are higher compared to the first quintile (p < 0,0001), with a predominance of these indicators in the female population.Conclusions. According to study, the content of non-HDL–C, and its prevalence of elevated levels in the population is high, especially in people with DM2, MS, AH. In terms of developing a platform for prevention of cardiovascular diseases, MS and DM2, the non-HDL–C ratio deserves attention as a target for further research.
Espor İzleyici Taleplerinin ve Twitch Bağışı ile İlişkisinin İncelenmesi
Authors: YALÇINER Serhat , KİLCİ Alp Kaan , GÜRTAY Kaan 
Published: December 2022

Amaç: Bu çalışmanın birincil amacı, çevrimiçi canlı yayın platformu Twitch üzerinden espor yayınlarını takip eden izleyicilerin yayın ve yayıncılardan taleplerinin oyun türü ve cinsiyet değişkenleri açısından değerlendirilmesidir. İkincil amacı ise, bu talep düzeylerinin yayıncıya bağış ile ilişkisinin incelenmesidir.
Materyal ve Yöntem: Çalışmaya 314’ü erkek, 116’sı kadın olmak üzere toplam 430 çevrimiçi espor izleyicisi katılmıştır. Veri toplama işlemi, Google Forms aracılığıyla katılımcı bilgi formu ve Espor İzleyici Talepleri Ölçeği kullanılarak gerçekleştirilmiştir. Verilerin istatistiksel analizi SPSS programı aracılığıyla yapılmıştır. Verilerin analizinde Bağımsız Örneklem t-Testi, Tek Yönlü Varyans Analizi ve Pearson Korelasyon Testi kullanılmıştır.
Bulgular: Espor izleyici talepleri ölçeği alt boyutlarından
etkileşim ve oyuncu özelliklerinde kadın izleyicilerin erkek izleyicilerden istatistiksel olarak anlamlı düzeyde yüksek talep puanlarına sahip oldukları (p.05). İzleyicilerin, yayıncılara bağışta bulunma düzeyleri ile izleyici talepleri alt boyutlarından sohbet odası alt boyutu arasında istatistiksel olarak pozitif yönde anlamlı ilişki olduğu (p.05).
Sonuçlar: Espor izleyicilerinin çevrimiçi yayınlardan taleplerinin etkileşim ve oyuncu özellikleri alt boyutu açısından cinsiyet değişkeninden etkilendiği ve sohbet odasından talepleri yüksek olan izleyicilerin, yayıncılara daha fazla bağışta bulunduğu görülmüştür.
Praktik Siniar dan Gerakan Literasi Perempuan
Authors: Dewi Sulih Indra , Lasari Yuni , Primasti Dinar 
Published: December 2022

Pemanfaatan media baru bagi perempuan menjadi kajian yang menarik untuk dibahas. Perkembangan internet sudah tidak bisa dibendung dan setiap orang bisa ikut berpartisipasi di dalamnya termasuk perempuan. Perempuan memanfaatkan platform siniar atau podcast untuk menyuarakan gerakan literasi digital bagi perempuan. Tujuan dari penelitian ini adalah untuk mengetahui bagaiamana gerakan literasi perempuan dengan menggunakan media baru dalam praktik siniarnya. Penelitian ini merupakan penelitian kualitatif dengan menggunakan metode studi kasus pada siniar Suara Puan yang dikelola oleh tiga orang perempuan, yaitu Stefany, Putri dan Idha. Suara Puan merupakan podcast exclusive Spotify yang berfokus pada literasi. Data penelitian diperoleh dengan teknik wawancara mendalam, observasi partisipatif dan dokumentasi. Hasil dari penelitian ini menunjukkan bahwa perempuan mampu menunjukkan kemampuannya dalam industri siniar/podcast yang didominasi oleh laki-laki. Suara Puan mampu menjadi ruang literasi bagi perempuan. Tanpa disadari siniar Suara Puan secara aktif telah melakukan gerakan literasi bagi perempuan sebagai bentuk digital activism. Suara Puan mampu menjawab keraguan bahwa perempuan gagap terhadap teknologi dengan memunculkan konten yang menarik dan mendatangkan keuntungan secara finansial. Respon dari pendengar siniar inipun sangat positif karena mereka merasa diajak untuk mencintai literasi dengan memanfaatkan media baru yang lebih akrab bagi mereka dan memunculkan kesadaran-kesadaran baru sebagai perempuan. Sebagai sebuah aktifisme, meskipun tidak secara terang-terangan diakui oleh para pembuat, tapi dengan secara konsisten membangun kesadaran literasi menjadikan praktik siniar ini mampu menggerakkan pendengarnya.
Kata Kunci: Podcast, Siniar, Perempuan, Literasi digital, media baru, digital activism
Public Services Bureaucracy Performance (Case Study Of Public Relation, Information And Public Communications in South Sulawesi Province)
Authors: Parebba Zainal Arifin , Hamsina  , Ahmad Badu , Anugrah Edhib Harits 
Published: December 2022

Abstract
The research entitled Public Service Bureaucracy Performance (Case Study Of Public Information and Public Communications) has several problems, including the lack of maximum services provided by the communication and informatics department in terms of services to the community. Basically, research on the quality of public services is important to do, because the community as customer service has not been satisfied in terms of time, cost and quality of service that has been provided. For this reason, this research is aimed at improving the quality of public services, especially those carried out in the field of Public Relations, Information and Public Communication, South Sulawesi Province. To see the phenomenon above, the writer uses the Dwiyanto theory with five indicators, namely productivity, service quality, responsiveness, responsibility and accountability. In this study, the author uses a qualitative method with a case study approach. The results found are still rampant, sometimes admin operators are less responsive and sometimes operators do not understand that the report will be forwarded to the relevant agency. And the time of service is also not certain.

Abstrak
Penelitian yang berjudul Kinerja Birokrasi Pelayanan Publik (Studi Kasus Informasi Publik dan Komunikasi Publik) memiliki beberapa permasalahan, antara lain kurang maksimalnya pelayanan yang diberikan oleh dinas komunikasi dan informatika dalam hal pelayanan kepada masyarakat. Pada dasarnya penelitian tentang kualitas pelayanan publik penting untuk dilakukan, karena masyarakat sebagai pelanggan pelayanan belum puas dalam hal waktu, biaya dan kualitas pelayanan yang telah diberikan. Untuk itu penelitian ini ditujukan untuk meningkatkan kualitas pelayanan publik khususnya yang dilaksanakan di bidang Humas, Informasi dan Komunikasi Publik Provinsi Sulawesi Selatan. Untuk melihat fenomena diatas, penulis menggunakan teori Dwiyanto dengan lima indikator yaitu produktivitas, kualitas pelayanan, daya tanggap, tanggung jawab dan akuntabilitas. Dalam penelitian ini, penulis menggunakan metode kualitatif dengan pendekatan studi kasus. Hasil yang ditemukan masih merajalela, terkadang admin operator kurang tanggap dan terkadang operator tidak mengerti bahwa laporan akan diteruskan ke instansi terkait. Dan waktu pelayanannya juga tidak pasti.
Kebijakan Pemilihan Umum Pasangan Calon Tunggal Presiden dan Wakil Presiden
Authors: Syah Ardan Ardian 
Published: December 2022

Abstract
This study focuses on the discussion related to the constitutionality of a single candidate pair in the election of President and Vice President. With the space given by the constitution and from the provisions of Law Number 7 of 2017 and also strengthened through the decision of the Constitutional Court, then the behavior of political parties themselves causes a single candidate in the election of President and Vice President to occur. The existence of a single candidate can be accepted by democracy when faced with an empty box which will create problems and negative views in the implementation of democracy in Indonesia. The existence of a single candidate in the presidential and vice presidential elections raises constitutionality problems so that the existence of a single candidate in the presidential election is highly avoided. This study uses a normative juridical method, with a statutory approach, and a conceptual approach.

Abstrak
Dalam Penelitian ini memfokuskan pembahasan terkait konstitusionalitas pasangan calon tunggal dalam pemilihan Presiden dan Wakil Presiden. Dengan adanya ruang yang diberikan konstitusi dan dari ketentuan Undang-Undang Nomor 7 tahun 2017 serta dikuatkan juga melalui putusan Mahkamah Konstitusi yang kemudian adanya perilaku partai politik itu sendiri menyebabkan calon tunggal dalam pemilihan Presiden dan Wakil Presiden dapat saja terjadi. Keberadaan calon tunggal dapat diterima oleh demokrasi apabila dihadapkan dengan kotak kosong yang mana akan memunculkan permasalahan dan pandangan yang negatif dalam pelaksanaan demokrasi di Indonesia. Keberadaan calon tunggal dalam pelaksanaan pemilihan Presiden dan Wakil Presiden memunculkan problem konstitusionalitas sehingga adanya calon tunggal dalam Pilpres sangat dihindarkan. Penelitian ini menggunakan metode yuridis normatif, dengan pendekatan perundang-undangan, dan pendekatan konseptual.
Prediksi Kebangkrutan dan Penilaian Kesehatan Bank Syariah untuk Menentukan Strategi Penambahan Modal Inti Bagi Kelompok Bank Modal Inti 1 Berdasarkan Peraturan OJK Nomor 12/POJK.03/2020
Authors: Nur Ellyanawati Esty Rahayu  
Published: December 2022

Penelitian ini bertujuan untuk memprediksi kebangkrutan dan tingkat kesehatan bank syariah kelompok bank modal inti 1 sehingga dapat ditentukan strategi penambahan modal inti berdasarkan Peraturan OJK Nomor 12/POJK.03/2020 tentang Konsolidasi Bank Umum yang menetapkan modal inti minimal Rp 3 triliun pada 31 Desember 2022. Masih terdapat 5 bank syariah KBMI 1 yaitu PT Bank BCA Syariah, PT Bank Mega Syariah, PT Bank Panin Dubai Syariah Tbk, PT Bank Victoria Syariah, dan PT Bank Aladin Syariah Tbk. Penelitian ini menggunakan analisis Z-Score, CAMEL dan RGEC. Hasil yang diperoleh yaitu 1) KBMI 1 dapat menggunakan analisis Z-Score untuk memprediksi kesulitan keuangan/ kebangkrutan dan tingkat kesehatan bank dengan analisis CAMEL dan RGEC. 2) Bank syariah KBMI 1 agar mengupayakan penambahan modal inti pada trisemester IV 3) Bagi bank syariah dengan hasil penilaian sehat dan grey area dapat meminta bank induknya untuk menambah modal inti. 4) Bagi bank syariah yang hasil predikatmya kurang sehat ataupun cukup sehat, bisa mencari investor dari bank atau perusahaan lain baik dari dalam negeri ataupun luar negeri. 5) Bagi bank syariah yang sudah listing di BEI bisa menerbitkan kembali saham baru atau right issue. 6) Alternatif terakhir adalah mengikuti skema yang disarankan OJK melalui skema penggabungan, peleburan, atau integrasi.
POTENSI OLAHAN TEPUNG UBIKAYU MENDUKUNG KETAHANAN PANGAN / The Potential of Processed Cassava Flour to Support Food Security
Authors: Dewayani Wanti , Arum Rifah Hestyani , Septianti Erina , Suriany Suriany , Basri Ekawaty , Amin Suarni 
Published: December 2022

<p>Food consumption patterns that only rely on one type of staple food are one of the causes of food security problems. The paper aims to review the role of cassava as a food security solution, as a substitute for wheat flour for noodle products and some of the results of noodle research from modified cassava flour and its potential in the carrot and spinach-based noodle industry. Cassava is one of the third most common local foods that can be developed to overcome food problems in Indonesia. Cassava can be processed into intermediate products and finished products and produce a diversity of food products. Noodles are the most preferred food by people today. This food product is made from wheat flour which is still imported in large quantities. Modified cassava can replace wheat flour in noodle making. Currently, the processing of healthy and gluten-free noodles can be made from modified cassava flour with spinach and carrot fortification.</p><p>Keywords: Cassava, food, noodles, wheat flour</p><p> </p><p><strong>Abstrak</strong></p><p>Pola konsumsi pangan yang hanya bertumpu pada satu jenis bahan pangan pokok merupakan salah satu penyebab timbulnya masalah ketahanan pangan. Tulisan ini bertujuan mengulas peran ubi kayu sebagai salah satu solusi ketahanan pangan, sebagai pengganti terigu untuk produk mie dan beberapa hasil penelitian mie dari tepung ubi kayu termodifikasi serta potensinya dalam industri mie berbasis wortel dan bayam. Ubi kayu merupakan salah satu pangan lokal terbanyak ketiga yang dapat dikembangkan untuk mengatasi masalah pangan di Indonesia. Ubi kayu dapat diolah menjadi produk antara dan produk jadi dan menghasilkan keanekaragaman produk pangan. Mie merupakan makanan yang paling disukai oleh masyarakat saat ini. Produk pangan ini dibuat dari tepung terigu yang hingga kini masih diimpor dalam jumlah besar. Tepung ubi kayu termodifikasi dapat menggantikan tepung terigu dalam pembuatan mie. Saat ini pengolahan mie sehat dan bebas gluten dapat dibuat dari tepung ubi kayu termodifikasi dengan fortifikasi bayam dan wortel.</p><p>Kata kunci: Ubi kayu, pangan, mie, terigu</p>
Long-term stability of PVDF-SiO2-HDTMS composite hollow fiber membrane for carbon dioxide absorption in gas–liquid contacting process
Authors: Pang Honglei , Qiu Yayu , Sheng Weipeng 
Published: December 2022

Abstract
Hybrid polyvinylidene fluoride-silica-hexadecyltrimethoxysilane (PVDF-SiO2-HDTMS) membranes were fabricated via a non-solvent-induced phase-inversion method to create stable hollow-fiber membranes for use in the membrane contact absorption of carbon dioxide (CO2). The surface properties, performance characteristics, and long-term performance stability of the prepared membranes were compared and analyzed. The outer surfaces of the prepared membranes were superhydrophobic because of the formation of rough nanoscale microstructures on the surfaces and their low surface free energy. The addition of inorganic nanoparticles improved the mechanical strength of the PVDF-SiO2-HDTMS. Long-term stable operation experiments were carried out with a mixed inlet gas (CO2/N2 = 19/81, v/v) at a flow rate of 20 mL/min. The absorbent liquid in these experiments was 1 mol/L diethanolamine(DEA) at a flow rate of 50 mL/min. The mass transfer flux of CO2 through the PVDF-SiO2-HDTMS membrane decreased from an initial value of 2.39 × 10− 3 mol/m2s to 2.31 × 10− 3 mol/m2s, a decrease of 3% after 20 days. The addition of highly stable and hydrophobic inorganic nanoparticles prevented pore wetting and structural damage to the membrane. The PVDF-SiO2-HDTMS membrane was found to have excellent long-term stable performance in absorbing CO2.
A New Method for Suppressing AM Broadcast signal by using DRM jamming signal
Authors: li shanshan , Li Jiang , Su Jie , Zhou Jian 
Published: December 2022

Abstract
The traditional method for suppressing AM broadcast signal is to transmit high-power AM broadcast jamming signal to suppress AM broadcast signal. To achieve better effect of jamming signal, it is often necessary to increase the transmitter power, which creates more difficulty and cost. Based on the jamming suppression system model, this study proposes a new method of using Digital Radio Mondiale (DRM) jamming signals to suppress AM broadcast signal. The relationship equation of the input Jamming-to-Signal Ratio (JSR)and output JSR of DRM jamming signal is derived, and the effectiveness of DRM jamming signal and AM jamming signal on AM broadcast signal is compared. The experimental results reveal that given the same output JSR, the input JSR of the DRM jamming signal is only one third of the input JSR of the AM jamming signal, which indicatesthe jamming efficiency of DRM jamming signal is three times that of AM jamming signal.
The association between periodontal disease and oral squamous cell carcinoma: a systematic review and meta-analysis
Authors: Li Rui , Hou Mengjie , Yu Liying , Luo Wen , Wang Hongyan 
Published: December 2022

Abstract
Background: The primary objective of this study was to investigate the relationship between periodontal disease (PD) and the prevalence of oral squamous cell carcinoma (OSCC).
Methods: The systematic search was performed using PubMed, Embase, Web of Science databases and Cochrane Library for the records published up to May 2022. Odds ratios (OR) and relative risk (RR) with 95% confidence intervals (95% CI) were estimated to evaluate this relationship using Stata version 12.0. Then, sensitivity analysis was performed accordingly. Begg’s test and Egger’s test were used to detect publication bias.
Results: Out of 964 papers from several databases, 13 studies concerning the association between PD and OSCC were included according to the inclusion criteria. Summary estimates showed that PD was positively associated with the prevalence of OSCC (OR = 3.28, 95% CI: 1.87-5.74), especially for severe PD (OR = 4.23, 95% CI: 2.92-6.13). No evident publication bias was revealed. No increased OSCC risk among patients with PD was shown according to the combined result (RR = 1.50, 95% CI: 0.93-2.42). Patients with OSCC exhibited significant differences in alveolar bone loss (ABL) (Weight mean difference (WMD) = 1.52, 95% CI: 1.32-1.72), clinical attachment loss (CAL) (WMD = 2.41, 95% CI: 0.45-4.37) and bleeding on probing (BOP%) (WMD = 9.72, 95% CI: 5.04-14.41) when compared with controls. A non-significant difference in tooth loss was observed (WMD = 0.88, 95% CI: -1.08-2.83).
Conclusion: The systematic review and meta-analysis suggested that there is a positive association between PD and OSCC prevalence. However, according to the current evidences, it’s unclear whether PD is an independent risk factor for OSCC.