bluuebunny/crossref_metadata_2025_split huggingface dataset:
The P21-Activated Kinase 1 and 2 As Potential Therapeutic Targets for the Management of Cardiovascular Disease
Authors: Xu Honglin , Wang Dingwei , Ramponi Chiara , Wang Xin , Zhang Hongyuan 
Published: December 2022

Review
The P21-Activated Kinase 1 and 2 As Potential Therapeutic Targets for the Management of Cardiovascular Disease

Honglin Xu, Dingwei Wang, Chiara Ramponi, Xin Wang, and Hongyuan Zhang *

Michael Smith building, Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
* Correspondence: hongyuan.zhang-3@postgrad.manchester.ac.uk

Received: 20 October 2022
Accepted: 16 November 2022
Published: 21 December 2022

Abstract: Group I p21-activated kinases (Paks) are members of the serine/threonine protein kinase family. Paks are encoded by three genes (Pak 1‒3) and are involved in the regulation of various biological processes. Pak1 and Pak2 are key members, sharing 91% sequence identity in their kinase domains. Recent studies have shown that Pak1/2 protect the heart from various types of stresses. Activated Pak1/2 participate in the maintenance of cellular homeostasis and metabolism, thus enhancing the adaptation and resilience of cardiomyocytes to stress. The structure, activation and function of Pak1/2 as well as their protective roles against the occurrence of cardiovascular disease are described in this review. The values of Pak1/2 as therapeutic targets are also discussed.
Advances of the Target-Based and Phenotypic Screenings and Strategies in Drug Discovery
Authors: Wang Shoubao , Wang Zihan , Fang Lianhua , Lv Yang , Du Guanhua 
Published: December 2022

Review
Advances of the Target-Based and Phenotypic Screenings and Strategies in Drug Discovery

Shoubao Wang 1,*, Zihan Wang1, Lianhua Fang1, Yang Lv2, and Guanhua Du1,*

1 Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
2 Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
* Correspondence: shoubaowang@imm.ac.cn (Shoubao Wang); dugh@imm.ac.cn (Guanhua Du).

Received: 8 November 2022
Accepted: 15 November 2022
Published: 21 December 2022

Abstract: Drug discovery and development is a complex and expensive process. There are two approaches, phenotypic and target-based approaches, each holding different advantages for screening novel drug candidates when pursuing successful marketing authorization. However, the attrition rates of drug candidates continue to increase. In this review, we discuss recent successes and ongoing advances in phenotypic screening and target-based screening for drug discovery. We also explore how strategic and technological innovations may fuel new approaches in drug discovery. There are two approaches in drug discovery.
Targeting Inflammation to Control Tissue Fibrosis
Authors: Song Weihua , Sun Wu , Wang Zilong , Teo Kelvin Yi Chong , Cheung Chui Ming Gemmy , Wang Xiaomeng 
Published: December 2022

Review
Targeting Inflammation to Control Tissue Fibrosis

Weihua Song 1, Wu Sun 2, Zilong Wang 3, Kelvin Yi Chong Teo 2,4,5, Chui Ming Gemmy Cheung 2,4,5, and Xiaomeng Wang 4,5,6,*

1 Innoland Biosciences, 6 West Beijing Road, Taicang 215400, Jiangsu, China.
2 Singapore National Eye Center, 11 Third Hospital Ave 168751, Singapore.
3 Ocean University of China, 5 Yushan Rd, Shinan District, Qingdao 266005, Shandong, China.
4 Singapore Eye Research Institute, 20 College Road 169856, Singapore.
5 Duke-NUS Graduate Medical School, 20 College Road 169856, Singapore.
6 Insitute of Molecular and Cell Biology, 61 Biopolis Dr, Proteos 138673, Singapore.
* Correspondence: xiaomeng.wang@duke-nus.edu.sg

Received: 17 November 2022
Accepted: 19 November 2022
Published: 21 December 2022

Abstract: Remodeling of the extracellular matrix (ECM) is an essential process in host defense against pathogens and tissue repair following injury. However, aberrant inflammatory responses could disturb ECM homeostasis leading to progressive disruption in tissue architecture and organ function. Fibrosis is the common outcome of a wide range of diseases, especially chronic inflammatory disorders, and represents the leading cause of morbidity and mortality globally. This review provides the current understanding of the pathogenesis of fibrosis, with particular emphasis on the role of inflammation in this process and the translational potential of targeting inflammation as a strategy to control fibrotic progression.
A Survey on Evolved LoRa-Based Communication Technologies for Emerging Internet of Things Applications
Authors: Yao Fang , Ding Yulong , Hong Shengguang , Yang Shuang-Hua 
Published: December 2022

Survey/review study
A Survey on Evolved LoRa-Based Communication Technologies for Emerging Internet of Things Applications

Fang Yao 1,3, Yulong Ding 2,3,*, Shengguang Hong 2,4, and Shuang-Hua Yang 2,5,*

1 The Ta-tech company, Nanjing 210009, China
2 Shenzhen Key Laboratory of Safety and Security for Next Generation of Industrial Internet, Department of Electronics and Information Engineering, Shenzhen University, Shenzhen 518060, China
3 Department of Computer Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China
4 The School of Computer Science and Technology, Harbin Institute of Technology, Harbin 150006, China
5 Department of Computer Science, University of Reading, West Berkshire RG6 6UR, United Kingdom
* Correspondence: dingyl@sustech.edu.cn; Shuang-hua.yang@reading.ac.uk

Received: 17 September 2022
Accepted: 17 October 2022
Published: 22 December 2022

Abstract: The concept of Internet of Things (IoT) greatly extends the coverage area that human being is able to perceive, access, and even control. By connecting various “Things” to the Internet, the IoT makes it possible to measure and manage the physical world as needed. As one of the most widely adopted Low Power Wide Area network technologies, the Long-Range-Radio (LoRa) has the features of long range, low power, and robustness, and thus plays an important role in building IoT applications where IoT objects are connected to the internet at affordable costs. Since the development of LoRa, many IoT applications have adopted LoRa and achieved success in the market. Currently, IoT technologies keep evolving towards different fields, giving rise to multifarious IoT applications including industrial IoT, smart city IoT, healthcare IoT, and direct-to-satellite IoT. In the meantime, LoRa also keeps developing and finding its position in various IoT applications either as a main or complementary player. The objective of this survey is to (1) provide a fundamental understanding of the LoRa technology; (2) explore research activities studying LoRa based communication systems for new IoT applications; and (3) demonstrate how the LoRa technology works together with other technologies to deliver better IoT services to end users.
From Emotion AI to Cognitive AI
Authors: Zhao Guoying , Li Yante , Xu Qianru 
Published: December 2022

Survey/review study
From Emotion AI to Cognitive AI

Guoying Zhao *, Yante Li , and Qianru Xu

University of Oulu, Pentti Kaiteran Katu 1, Linnanmaa 90570, Finland
* Correspondence: guoying.zhao@oulu.fi

Received: 22 September 2022
Accepted: 28 November 2022
Published: 22 December 2022

Abstract: Cognitive computing is recognized as the next era of computing. In order to make hardware and software systems more human-like, emotion artificial intelligence (AI) and cognitive AI which simulate human intelligence are the core of real AI. The current boom of sentiment analysis and affective computing in computer science gives rise to the rapid development of emotion AI. However, the research of cognitive AI has just started in the past few years. In this visionary paper, we briefly review the current development in emotion AI, introduce the concept of cognitive AI, and propose the envisioned future of cognitive AI, which intends to let computers think, reason, and make decisions in similar ways that humans do. The important aspect of cognitive AI in terms of engagement, regulation, decision making, and discovery are further discussed. Finally, we propose important directions for constructing future cognitive AI, including data and knowledge mining, multi-modal AI explainability, hybrid AI, and potential ethical challenges.
Preface: 3rd International Conference on Business Management, Humanities and Education Engineering (BMHEE 2022)
Authors: Zephaniah Hilary , Zhang Shihong 
Published: December 2022

BMHEE 2022 is the 2022 3rd International Conference on Business Management, Humanities and Education Engineering organized by the Shanxi Normal University, China and University of Southern Denmark, Denmark. The conference was held virtually on September 17-18, 2022 due to the Covid-10 pandemic and some of its restriction issues.
The main purpose of BMHEE 2022 is to bring together the professional practices, industrial experts, researchers, vocational teachers, academia, and decision-makers including the government to a unified communication forum for sharing their recent research and developmental activities in humanities science, business management and education technology. This conference provides a forum for all attendees to share and exchange ideas and research findings in respective fields of research. The conference allows the exchange of knowledge between different research domestic and foreign centers representing various fields.
We enjoyed 4 keynote speeches and many oral presentations made by the authors which lasted for 10-15 minutes each, and a lot of inspiration sparked during the Q&A parts. Researchers who have contributed their work to BMHEE 2022 shared their findings and experience with other researchers and attendees. Many participants without any contribution of research paper have also been allowed to attend the conference to gain knowledge in their respective areas. This conference is initiated to contribute cutting-edge ideas. Thanks to the dedication of every committee member and reviewer, we finally made this conference.
Organizing Committee of BMHEE 2022
Copenhagen, Denmark
4th International Conference on Electronic Science and Automation Control (ESAC 2022)
Authors: Alerander Martina , Tong Yang 
Published: December 2022

The 2022 4th International Conference on Electronic Science and Automation Control (ESAC 2022) was held during November 19-20, 2022 in Bangkok, Thailand as a virtual conference due to the growing concerns over the coronavirus outbreak (COVID-19), and in order to protect the well-being of our attendees, partners, and staff as our number one priority.
The objective of this conference was to provide a common platform to engineers, practitioners, scientists and researchers across the globe for exchanging their knowledge and views to deal with global challenges. The theme of this conference was not only the fundamental technology in the fields of electronic information, signal processing, electrocommunication, industrial electronics, electronic instrument, electronic science, automation and control technology, but also can change our society by exploring new horizons and continuous progress.
This scientific event brings together more than 150 national and international researchers. The conference model was divided into three sessions, including keynote sessions, virtual presentations and online Q&A discussion. All accepted papers were strictly selected based on originality, significance, relevance, and contribution to the area after being peer-reviewed.
We would like to acknowledge all of those who supported ESAC 2022. The help and contribution of each individual and institution was instrumental in the success of the conference.
The ESAC Scientific Committee
Bangkok, Thailand
Recent Progress of Hole Transport Layers of Inverted Perovskite Solar Cells
Authors: Liu Wei 
Published: December 2022

Perovskite solar cells, also known as PSCs, have become a potentially viable choice for a source of clean energy. This is especially true for the inverted structure, which boasts high stability and allows for synthesis by solution at low temperatures. In the inverse structure, one of the most important parts is called the hole transport layer, which plays a key role in acting as a substrate and transporting holes. Several studies on high-temperature liquids have been carried out as part of an effort to effectively enhance the device performance of inverted perovskite solar cells (IPSCs). In addition to common organic components, including PEDOT: PSS and PTAA, this paper also provides information regarding inorganic HTL materials, such as NiOx and compounds based on copper. This study discusses in depth the benefits and drawbacks of these four materials, as well as potential avenues for future research and development, such as the application of dopants and various interface optimization methodologies. It may be possible to improve the PCE of IPSCs as well as the stability if HTL materials are modified. This paper provides new researchers with a solid foundation and direction for optimizing HTL materials.
The Standard of Wireless Network Technology and Its Application in Router
Authors: Liu Xinming 
Published: December 2022

The development of routers has been a subject that has attracted researchers from a diverse range of fields including wireless networks standard and technology development. Make new products meet technical standards through continuous hardware upgrades such as chip updates and expansion of new frequencies. The direct effect of routers is that the speed of the Internet continues to increase, which promotes the development of many electronic products. By analyzing the development of routers and wireless network standards, this paper understands the general direction of future routers. The development of routers in the future needs to face the challenges of high network speed, low latency, intelligence, and more frequency bands. The application of hardware or new technology is a new opportunity brought by the development of routers.
Keyword: Traditional Network. WIFI development, Router
Further Research on Frequency Allocation (19-Cell System) Method based on IFR and FFR
Authors: Zhou Xiaodi , Chen Yuxiang , Chen Zhuo 
Published: December 2022

Many of the most advanced technology has a basic need for efficient telecommunication. In order to achieve this goal, the team should allocate those frequency channels in an intelligent way so that the interference can be reduced to the maximum extent. Here the team introduced a new method based on IFR3&IFR1 (Integer frequency reuse) in a 19-cell network, but also apply the FFR (fractional frequency reuse) method to reduce the interference ulteriorly. In the pure IFR situation, the integer frequency reuse factor and the cellular network specification collectively decide the network capacity. While in FFR only a fraction of the whole bandwidth is used by the users in the edge. By contrast, the users near the BS can make use of the total bandwidth. The cell is divided into an outer and an inner part in this effective way. Fractional Frequency Reuse (FFR) and its derivative method are accepted widely in the downlink (DL) inter-cell interference coordination(ICIC) schemes. The team also optimized the FFR method by measuring the distance in a more precise way. The team utilized Matlab to make a simulation of the system applying the new method and come to a couple of reasonable conclusions by comparing the FFR+IFR3 with FFR+IFR3. FFR+IFR3 has a better performance against FFR+IFR1 in a system whose distance between each cell is with more accuracy. While the average number of users per cell and transmission power for cell edge have little impact on average capacity. When the SNR increases, the network capacity starts steep but later flattens. Our method is more intelligent and can minish interference efficiently.
TÜRKİYE’DE ARAPÇA ÖĞRETİMİNDE ARAPÇA ÖĞRETMENLERİNİN YARATICI DRAMA YÖNTEMİNE İLİŞKİN GÖRÜŞLERİ
Authors: CEYLAN Senem 
Published: December 2022

Son yıllarda yapılandırmacı yaklaşıma dayalı öğretim anlayışının uygulanmaya başlamasıyla birlikte öğrenen merkezli yöntemler yaygınlık kazanmaya başlamıştır. Özellikle eğitim fakültelerinde drama programlarda yer almış ve öğretmen adaylarının drama yöntemiyle ilgili bilgi ve becerilerinin gelişimine ağırlık verilmiştir. Ancak öğretmen yetiştiren kurumlardan biri olan İlahiyat Fakültelerinde drama yönteminin programda yer almasıyla ilgili herhangi bir girişim olmadığı görülmektedir. Bu durumun İlahiyat Fakültesinde öğrenim gören öğrencilerin dramaya ilişkin bir bakış açısının oluşmamasının nedeni olduğu gibi uygulama süreçleri açısından Arapça dersinde yeterli ve etkin düzeyde drama yönteminin uygulanabilirliğine engel teşkil etmiştir.
Bu çalışmada İzmir örneğinde İmam Hatip Liselerinde görev alan Arapça öğretmenlerinin dramayla ilgili bakış açıları incelenmiştir. Drama yöntemiyle ilgili bilgi ve tutumları analiz edilmiş ve Arapça derslerinde kullanma düzeyleri araştırılmıştır. Özellikle İlahiyat Fakültesi çıkışlı Arapça öğretmenlerinin drama yöntemiyle ilgili bilgi ve tutumlarının yeterli düzeye ulaşmadığı ve uygulama süreçlerinde bazı sorunlar olduğu dikkati çekmektedir. Bu nedenle söz konusu öğretmenlerin drama ile ilgili farkındalık düzeylerinin yükseltilmesine öncelik verilmelidir. Bu çerçevede öğretmenlerin drama yöntemine ilişkin problemleri konusunda çözüm önerileri sunulacaktır.
Surgical Versus Nonsurgical Management of Humeral Shaft Fractures: A Systematic Review and Meta-Analysis of Randomized Trials
Authors: Oliver William M. , Bell Katrina R. , Molyneux Samuel G. , White Timothy O. , Clement Nicholas D. , Duckworth Andrew D. 
Published: December 2022

Introduction:
The aim was to compare surgical and nonsurgical management for adults with humeral shaft fractures in terms of patient-reported upper limb function, health-related quality of life, radiographic outcomes, and complications.

Methods:
MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, PubMed, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, International Clinical Trials Registry, and OpenGrey (Repository for Grey Literature in Europe) were searched in September 2021. All published prospective randomized trials comparing surgical and nonsurgical management of humeral shaft fractures in adults were included. Of 715 studies identified, five were included in the systematic review and four in the meta-analysis. Data were extracted by two independent reviewers according to the Preferred Reporting Items for Systematic Review and Meta-Analysis statement. Methodological quality was assessed using the revised Cochrane risk-of-bias tool for randomized trials. Pooled data were analyzed using a random-effects model.

Results:
The meta-analysis comprised 292 patients (mean age 41 [18 to 83] years, 67% male). Surgery was associated with superior Disabilities of the Arm, Shoulder and Hand (DASH) and Constant-Murley scores at 6 months (mean DASH difference 7.6, P = 0.01; mean Constant-Murley difference 8.0, P = 0.003), but there was no difference at 1 year (DASH, P = 0.30; Constant-Murley, P = 0.33). No differences in health-related quality of life or pain scores were found. Surgery was associated with a lower risk of nonunion (0.7% versus 15.7%; odds ratio [OR] 0.13, P = 0.004). The number needed to treat with surgery to avoid one nonunion was 7. Surgery was associated with a higher risk of transient radial nerve palsy (17.4% versus 0.7%; OR 8.23, P = 0.01) but not infection (OR 3.57, P = 0.13). Surgery was also associated with a lower risk of reintervention (1.4% versus 19.3%; OR 0.14, P = 0.04).

Conclusions:
Surgery may confer an early functional advantage to adults with humeral shaft fractures, but this is not sustained beyond 6 months. The lower risk of nonunion should be balanced against the higher risk of transient radial nerve palsy.

Level of Evidence:
Level I.
Effectiveness of Consuming Phoenix Dactylifera L to Increase Platelets in Dengue Hemorrhagic Fever Patients
Authors: Yuhadi Asfani , Azizi Jayadipraja Erwin , Sunarsih Sunarsih 
Published: December 2022

Introduction: Based on the data from Southeast Sulawesi Provincial Health Office in 2017-2020, the prevalence of Dengue Hemorrhagic Fever has increased from year to year. The prevalence of Dengue Hemorrhagic Fever (DHF) cases for Southeast Sulawesi Province in 2017 was 32.4 per 100,000 population, increased to 38.4 per 100,000 population in 2018, increased to 63.5 per 100,000 population in 2019, and increased to 70.5 per 100,000 population in 2020. This research aimed to analyze the effectiveness of consuming Phoenix Dectylifera L, to increase platelets in DHF patients.
Method: This research employed a retrospective cohort study. This research has been carried out for 30 days. The population was 176 people. The research sample consisted of 74recovered DHF patients. Meanwhile, home visits were conducted to observe the consumption of Phoenix Dectylifera L. The sampling technique was simple random sampling. The data was processed using the Data Normality Test (Kolmogorov Smirnov Test) and Anova Test.
Result: The results of this research showed that the value 0.000 of consuming Phoenix Dectylifera L, to increase platelets in Dengue Hemorrhagic Fever (DHF) patients with 6 (six) days of treatment.
Conclusion: There is an effect between consuming and not consuming Phoenix Dectylifera L, to increase platelets in Dengue Hemorrhagic Fever (DHF) patients.
Pengembangan Media Pembelajaran Augmented Berbasis Android
Authors: Welli Andika Pitra , Alfitriani Adlia , Darman Regina Ade 
Published: December 2022

SMK Negeri 1 Ampek Angkek pada umumnya pembelajaran menggunakan lisan terutama pada materi Virtual Lokal Area Network (VLAN) sehingga siswa terkadang bosan saat proses pembelajaran yang sedang berlangsung, adapun guru sudah menggunakan media namun masih dalam bentuk buku membuat siwa masih sulit mengimplementasikan materi pelajaran dalam dunia nyata.Tujuan penelitian ini adalah mengetahui valid dan praktis penggunaan media pembelajaran Augmented Reality berbasis android pada materi Virtual Local Area Network (VLAN) mata pelajaran Administrasi Infrastruktur. Jenis penelitian ini menggunakan Metode penelitian Research and Development adalah metode penelitian yang bertujuan untuk menganalisis kebutuhan yang kemudian dilanjutkan dengan membuat media pembelajaran untuk menunjang kejelasan materi yang disampaikan oleh guru Hasil penelitian dan pembahasan pengembangan media pembelajaran Augmented Reality berbasis android pada materi Virtual Lokal Area Network (VLAN) dapat disimpulkan bahwa Media pembelajaran Augmented Reality berbasis android layak digunakan sebagai media pembelajaran untuk siswa kelas XI TKJ dengan rata-rata validitas 0,755 dengan kategori valid untuk media sedangkan validasi materi dengan rata-rata 3333 dengan kategori valid.
Penggunaan Media Prezi untuk Meningkatkan Hasil Belajar Seni Rupa Kelas XII MIPA 3 SMAN 2 Dumai
Authors: Pratiwi Vindi , Awrus Suib 
Published: December 2022

Penggunaan media pembelajaran di kelas ini memiliki tujuan untuk mendemonstrasikan metode penggunaan Prezi dalam pembelajaran seni rupa dan meningkatkan hasil belajar seni rupa di kelas XII MIPA 3 Dumai. Jenis penilitian yang digunakan ialah penelitian tindakan kelas. Metode dan alat pengumpul data yaitu observasi, tes, dan tugas siswa. Prosedur penelitian berbentuk siklus dengan beberapa tahap. Setiap siklusnya terbagi menjadi 4 langkah: merencanakan, melakukan, mengamati, dan berpikir. Alat penelitian meliputi tes prestasi siswa, evaluasi kinerja guru, dan evaluasi kinerja siswa. Nilai didapatkan dari penelitian menunjukkan terjadinya peningkatan dari hasil tes belajar siswa selama proses belajar. Hasil tes belajar siswa dalam prasiklus didapatkan dalam nilai rata-rata 66,54, hasil belajar siklus 1 didapatkan nilai rata-rata 75,22, selanjutnya siklus 2 hasil tes belajar yang didapat siswa mengalami peningkatan yang meningkatan dalam nilai rata-rata menjadi 85,62.

Kata kunci: Monitoring PKL, Codeigniter, SDLC, MYSQL, Web