bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modified medial minimally invasive plate osteosynthesis techniques for the treatment of distal third diaphyseal fracture of humerus using a double plate technique
Authors: Ye Youyou , Lin Yanbin , Wu Chunling , Zhu Yunzhe 
Published: May 2023

Abstract
Purpose The surgical approach and the placement of plates for the treatment of distal third diaphyseal fracture of the humerus are controversial. The aim of this retrospective study was to evaluate the clinical and radiographic outcomes when modified medial minimally invasive plate osteosynthesis (MIPO) techniques for the treatment of distal third diaphyseal fracture of the humerus using a double plate technique were performed.Methods A total of 20 patients with a distal third diaphyseal fracture of the humerus were selectd from our hospital. Patients were seen between January 2017 and May 2019. They were treated with a modified medial approach combined with MIPO techniques using a double plate technique. Patient demographics, operation time, bleeding volume, union time, complication, the mean fracture length(FL) and distal cortical length (DCL), and the number of screws in the distal fragment were analyzed. The function of the shoulder and elbow were evaluated using Neer's assessment of the shoulder and Mayo's assessment of the elbow.Results The FL was 57.7 ± 7.7mm and the DCL 39.1 ± 5.2mm. The mean operative time was 88.3 ± 12.6min (range 60-110min). The mean blood loss on surgical treatment was 47.8 ± 10.6ml(range 30-60ml). Bone healing was observed in all patients from 10 to 14 weeks (average 11.9 ± 1.8) and there were no complications recorded. All the patients had good function of both the shoulder and elbow. The maximum flexibility of the elbow ranged from 130° to 145° (average 138.5 ± 4.9°) with maximum flexibility straightness 0° to 5° (average 2.2 ± 1.5°). The Mayo elbow joint function score was 80–100 (average 92.7 ± 5.1). The Neer shoulder joint function score was from 85–100 (average 93.6 ± 3.5).Conclusion The modified medial approach had the advantages of no iatrogenic radial nerve nor ulnar nerve injuries. The anterior and the medial side plate were fixed perpendicular to the distal humerus and can offer higher stability at the same time producing better shoulder and elbow joint function.
Behavioral Evidence for Global Consciousness Transcending National Parochialism
Authors: Liu James H. , Choi Sarah Y. , Lee I-Ching , Leung Angela K-y. , Lee Michelle , Lin Mei-Hua , Hodgetts Darrin , Chen Sylvia Xiaohua 
Published: May 2023

Abstract
While national parochialism is commonplace, individual differences explain more variance in it than cross-national differences. Global consciousness (GC), a multi-dimensional concept that includes identification with all humanity, global prosociality, and respect for cultural diversity, transcends national parochialism. Across cultures (N = 11163), most notably the USA and China, individuals high in GC were more generous allocating funds to the other in a dictator game, cooperated more in a one-shot prisoner’s dilemma, and differentiated less between the ingroup and outgroup on these actions. They gave more to the world and kept less for the self in a multi-level public goods game. GC profiles showed 80% test-retest stability over 8 months. Implications of GC for cultural evolution in the face of trans-border problems are discussed.
Multi-omics approach reveals influenza-A virus target genes associated genomic, clinical and immunological characteristics in cancers
Authors: Wang Jiaojiao , Liao Yong , Yang Pinglian , Ye Weile , Liu Yong , Xiao Chunxia , Liao Weixiong , Chen Chunbo , Liu Zhiping , Huang Zunnan 
Published: May 2023

Abstract
Influenza A virus has been shown to be closely linked to diverse malignancies and may work as an oncovirus. However, the specific role of influenza A virus as well as its target genes in cancer initiation and progression remain unclear. Thus, in this study, a comprehensive evaluation of influenza A virus target genes (IATGs) was performed in thirty-three tumor types by using multi-omics data from The Cancer Genome Atlas (TCGA) and The Cancer Proteome Atlas (TCPA) databases. In the genomic landscape, a high frequency of genetic and epigenetic alterations in the IATGs were found and subsequently affected tumor progression. Moreover, transcriptome analysis revealed that the expression of IATGs was differentially expressed in diverse tumors and could be used to predict clinical survival in patients. In addition, IATGs were also closely associated with cancer-related signaling pathways as well as the immune microenvironment. Furthermore, the involvement of IATGs in the regulation of the resistance of anti-cancer drugs was uncovered. The transcript expression of six identified IATGs in kidney renal clear cell carcinoma (KIRC) was validated by qRT-PCR. In conclusion, this study revealed the genomic alterations and clinical features of IATGs, which may provide new hints for exploring the potential molecular mechanisms between tumors and the influenza A virus. This will also provide new clues for developing novel targeted therapeutic strategies such as viral immunotherapy, promoting the discovery of tumor-related viruses, and designing individualized treatment for tumor patients.
Flow field analysis of nutation blood pump based on heart-pump coupling model and speed control
Authors: Zhang Bo , Yao Ligang , Liu Yaming , Luo Biaolin 
Published: May 2023

Abstract
The active speed modulation of the blood pumps is considered an effective strategy for reducing postoperative complications. Nutation blood pumps have attracted widespread attention due to their small size, low rotational speed, and low risk of embolism, but there is a lack of research on the feasibility of rotational speed regulation. Therefore, the purpose of this article is to research the effect of the speed regulation of the nutation blood pumps on its internal flow field and blood damage. In this article, a cardiovascular system-nutation blood pump coupling model is proposed based on the human blood circulation system. The computational fluid dynamics (CFD) method is used to simulate the internal flow of the whole flow channel under the modulation of the rotational speed of the nutation blood pump. The coupling model was numerically simulated under speed regulation, and the obtained left ventricular and aortic pressures were set as the inlet and outlet boundary conditions for the CFD simulation of the blood pump. The blood pump flow field and blood damage are analyzed under four rotational speed conditions (the uniform speed, the sine wave, the square wave, and the triangular wave). The results show that the flow pulsation of the blood pump under speed regulation is enhanced, which is a feasible solution to restore the blood flow fluctuation. Among them, the flow pulsation index of the blood pump under the sinusoidal speed regulation is the highest, which is 1.91 times that of the uniform speed state. At the same time, the degree of blood damage in the blood pump is relatively low, which is an ideal speed regulation waveform.
The Book Forum:Recommendation Application System using Collaborative Filtering and Autoencoders
Authors: Chawade Ayushi , Khairnar Kalpesh , Khamkar Vaishnavi , Sonawane Pratham 
Published: May 2023

Abstract
Reading books are a great way to escape from the hectic routine of our daily lives. It allows us to step away from reality and enter another world. The book recommendation system also encourages the students to broaden their horizons and discover new genres and authors they may have never encountered before. Algorithms such as collaborative filtering, content-based, association rules, etc. have been in existence to develop personalized book recommendations based on the user's preferences and reading history. In addition, book recommendation systems have become increasingly popular in the digital age due to the convenience and accessibility of e-books and audiobooks. An approach with a hybrid of content and collaborative filtering is an effective method for creating personalized book recommendations with neural network architecture on the algorithm. This approach can provide more accurate recommendations by combining the user's preferences and reading history with the characteristics of the books, such as genre, and author with more scalability and accuracy making it suitable for large-scale book recommendation systems used by online bookstores or libraries. A book recommendation system can significantly enhance the user's reading experience by providing personalized suggestions that cater to their interests and preference.
Establishing comprehensive quaternary structural proteomes from genome sequence
Authors: Mih Nathan , Lu Maxwell , Palsson Bernhard , Catoiu Edward 
Published: May 2023

Abstract
A critical body of knowledge has developed through advances in protein microscopy, protein-fold modeling, structural biology software, availability of sequenced bacterial genomes, large-scale mutation databases, and genome-scale models. Based on these recent advances, we develop a computational platform that; i) computes the oligomeric structural proteome encoded by an organism’s genome; ii) maps multi-strain alleleomic variation, resulting in the structural proteome for a species; and iii) calculates the 3D orientation of proteins across subcellular compartments with angstrom-level precision. Using the platform, we; iv) compute the full quaternary E. coli K-12 MG1655 structural proteome; v) deploy structure-guided analyses to identify consequential mutations; and, in combination with a genome-scale model that computes proteome allocation, vi) obtain a draft 3D visualization of the proteome in a functioning cell. Thus, in conjunction with relevant datasets and computational models, we can now resolve genome-scale structural proteomes to obtain an angstrom-level understanding of whole-cell functions.
Bacterial community structure and mucin drive Pseudomonas aeruginosa diversification and pathoadaptation
Authors: Johansen Helle Krogh , Pitchford Jon , Friman Ville-Petri , Bottery Michael 
Published: May 2023

Abstract
While several environmental factors contribute to the evolutionary diversification of the pathogenic bacterium Pseudomonas aeruginosa during cystic fibrosis lung infections, relatively little is known about the impact of the surrounding microbiota. By using in vitro experimental evolution, we show that virulent subpopulations of P. aeruginosa are maintained in the presence of interspecies competition by Stenotrophomonas maltophilia, Staphylococcus aureus, or them both, but lost in the absence of competition due to mutations in genes involved in Las, Rhl, and Pseudomonas Quinolone Signal quorum sensing systems. Moreover, the strength of competition is attenuated through changes in the physical environment by the addition of mucin, resulting in selection for phenotypes resembling those evolved in the absence of competition. Together, our findings show that variation in mucosal environment and interspecies interactions can determine the evolutionary trajectory of P. aeruginosa, partly explaining its diversification and pathoadaptation from acute to chronic phenotype during CF lung infections.
Maximizing Renewable Energy Integration in Distribution Networks: An ESCSO Algorithm for Optimal PV and WT Planning under Uncertainty
Authors: Abdel-Mawgoud Hussein , Kamel Salah , Hassan Mohamed H. , Selim Ali , El-Sehiemy Ragab , Shaheen Abdullah , Jurado Francisco 
Published: May 2023

Abstract
With the rapid growth of technology and population, there has been a corresponding increase in electricity demand and system load. To meet this demand, the installation of renewable energy sources (RESs), such as wind turbines (WTs) and photovoltaics (PVs), in distribution systems is widely accepted as the best solution. This paper proposes an efficient modified method called ESCSO, which combines the Sand Cat Swarm Optimizer (SCSO) and Marine Predators Algorithm (MBA) algorithms to obtain the optimal allocation of WT and PV in radial distribution systems (RDS), with and without inverters. The presented objective function considers system loss, variable load, and the probabilistic output of WT and PV over 24 hours. The IEEE 69-bus RDS is used as the test system, with its equality and inequality constraints. The ESCSO method is compared with the original SCSO and MBA algorithms to measure its efficiency. The results show that installing multiple WT and PV yields better results than using a single WT and PV in RDS. Furthermore, incorporating WT and PV with an enabling inverter yields better results than using WT and PV without an enabling inverter in RDS.
Multiparadigm modeling of texture effects on pitting corrosion in ferritic stainless steel
Authors: Jamebozorgi Vahid , Rasim Karsten , Schröder Christian 
Published: May 2023

Abstract
Texture has long been recognized as a critical factor influencing the physical processes and properties of condensed matter. In this study, we implemented a multiparadigm approach and introduce a robust methodology to investigate the effects of texture in corrosion, which overcomes the common limitations of quantum-based computational approaches in terms of time and system size. Our approach provides the same level of accuracy as atomistic calculations but with significantly less computational cost. The methodology, based on the finite element method (FEM), employs 3D digital representations of polycrystalline microstructures. As a proof of concept, we apply our approach to the case of pitting corrosion in ferritic stainless steel. As shown in the literature irregular pit growth patterns through pitting corrosion are primarily caused by texture. Our study reveals that texture has a significant impact on the pitting corrosion rate leading to a wide range of irregular pit growth patterns in polycrystals. Our findings are supported by atomistic calculations and experimental literature, demonstrating the validity of our approach.
Anticancer analysis of CD44 targeted Cyclosporine loaded thiolated chitosan nanoformulations for sustained release in triple-negative breast cancer
Authors: Abduh Maisa Siddiq 
Published: May 2023

Abstract
Cyclosporine (CsA), a potent immunosuppressive chemotherapeutic medication, treats numerous cancers, particularly malignant carcinoma, acute leukemia, and triple-negative breast cancer (TNBC). A specified polymeric nanoformulation (NF) based drug delivery technique with ligand alteration at the surface was developed to improve active moiety delivery at the intended area and boost the efficacy of prolonged treatment. We produced and characterized NF of encapsulated Cyclosporine in thiolated chitosan (TC) with the outermost coating of hyaluronic acid (HA). Research conducted in-silico verified that HA binds to the receptor CD44 at docking locations A and B in triple-negative breast cancer cells. When a pharmaceutical substance interacts with a polymeric compound, zeta examination reveals a particle size of 192nm, a PDI of 0.433, and a zeta potential of 38.9mV. FTIR and Raman's investigations also support the existence of hydrophobic groups, porous surfaces, and clumping characteristics. While XRD verified its crystallographic nature, which renders NF particularly helpful in localized drug delivery systems (DDS), SEM and TEM revealed circular nanoparticles with sleek exteriors. DSC demonstrated that NF was stable at high temperature. The NF showed 85% drug encapsulation and a kinetics investigation of drug release revealed that the NF obeyed the Higuchi model for dispersion at low pH. In contrast to typical CsA's immediate release in under 12 hours, the in-vitro investigation demonstrated prolonged continuous dissolution at pH 7.4 and 6.8 for a maximum of 72 hours. When compared to raw Cyclosporine, the in-vitro tumor prevention properties of the ThC-HA encapsulated with Cyclosporine were tested using an MTT test on normal breast epithelial cells and triple-negative breast cancer cells. It showed the synthesized NF's robust cytotoxic potential at reduced concentrations and its effectiveness for normal cells. These characteristics improve the long-term viability, effectiveness, and active targeting of prepared novel NFs as an effective pharmaceutical component as a potent therapeutic moiety against cancer.
AI chatbot responds to emotional cuing
Authors: Zhao Yukun , Xu Liying , Huang Zhen , Peng Kaiping , Seligman Martin , Li Evelyn , Yu Feng 
Published: May 2023

Abstract

Emotion has long been considered to distinguish humans from Artificial Intelligence (AI). Previously, AI's ability to interpret and express emotions was seen as mere text interpretation. In humans, emotions co-ordinate a suite of behavioral actions, e.g., under negative emotion being risk averse or under positive emotion being generous. So, we investigated such coordination to emotional cues in AI chatbots. We treated AI chatbots like human participants, prompting them with scenarios that prime positive emotions, negative emotions, or no emotions. Multiple OpenAI ChatGPT Plus accounts answered questions on investment decisions and prosocial tendencies. We found that ChatGPT-4 bots primed with positive emotions, negative emotions, and no emotions exhibited different risk-taking and prosocial actions. These effects were weaker among ChatGPT-3.5 bots. The ability to coordinate responses with emotional cues may have become stronger in large language models as they evolved. This highlights the potential of influencing AI using emotion and it suggests that complex AI possesses a necessary capacity for “having” emotion.
Comparison between Conventional Approach and Three-Dimensional Mapping System in the Catheter Ablation of Accessory Pathway Associated with Coronary Sinus Diverticulum: A Single Center Experience
Authors: Chen Mingxian , Wu Zhihong , Hu Lin , Li Xuping , Liu Qiming , Zhou Shenghua 
Published: May 2023

Abstract
Background
Posteroseptal accessory pathways (APs) associated with coronary sinus (CS) diverticulum present a rare and challenge for ablation. This study aimed to compare the safety and efficacy of conventional approach and three-dimensional (3D) mapping system in the catheter ablation.
Methods and Results
This was a retrospective study of all patients (from January 2013 to July 2022) who underwent catheter ablation of posteroseptal AP associated with CS diverticula in our center. Patients who underwent catheter ablation using the traditional fluoroscopy method were included in the Conventional method group (n = 13). Patients who underwent catheter ablation using the 3D mapping method were included in the 3D mapping group (n = 11). Clinical characteristics, ablation procedure and outcomes were recorded and analyzed between the two groups. Out of 669 patients with posteroseptal APs, 24 of them (3.6%) were associated with CS diverticula. All patients in both groups successfully completed the electrophysiological study. In the Conventional method group, two patients experienced complications, and two patients had recurrence. However, no patients suffered from complications or recurrence during follow-up. The procedure time and fluoroscopy time in the Conventional method group were significantly longer than those in the 3D mapping method group.
Conclusions
The 3D mapping method is much safer and more effective than the conventional method in the catheter ablation of posteroseptal APs associated with CS diverticula.
The Research Characteristics, Hotspots, and Transmutations of Aerobics in China: Research on Visualization based on Scientific Knowledge Graph
Authors: Wang Yang , Zainudin Z. A. 
Published: May 2023

Abstract
A total of 679 core journal papers retrieved from CNKI database were used as literature samples. CiteSpace software was used to visually analyze the titles, keywords, abstracts, and other literature materials. From the perspective of scientific knowledge graph, the distribution of authors and institutions with great influence in the research of aerobics was discussed. In order to clarify the research characteristics of aerobics, hot subjects and frontier evolution. Study found that aerobics research focus has been developed from the early public teaching mode, investigation and countermeasure research now gradually to the sport, competitive aerobics, physical education and aerobics athletes’ transition, aerobics without expanding the research field, research topics tend to diversification, popular, empirical and theoretical research is also in constant depth development. The research frontiers are divided into three periods: early stage, middle stage, and recent stage, with different research directions and emphases. It is suggested to construct multidisciplinary integrated development, enrich the vision of teaching and competition, improve the local regional integration policy, and comprehensively display the research and development status of aerobics.
Genome-wide discovery and characterization of major RNAi gene families in Date palm (Phoenix dactylifera)
Authors: Naim Md Darun , Ahsan Md Asif , Imtiaj Ahmed , Mollah Md Nurul Haque 
Published: May 2023

Abstract
Dates have various minerals and health advantages, however, its major RNA interference (RNAi) genes are not yet studied, though these gene families play a vital role in controlling other protein coding genes. Therefore, we designed this in silico study to explore major RNAi genes highlighting their phylogenetic groups, domains, structures, locations, molecular functions, regulatory factors of date palm. Initially, a BLASTP search on date palm genome governed by the Arabidopsis thaliana RNAi genes (query sequences) predicted 4 DCLs, 7 AGOs, and 3 RDRs genes as key RNAi genes families of date palm. Domain analysis revealed the Helicase_C, Dicer_dimer, PAZ, RNase III, and Piwi domains of projected RNAi genes that are associated with the gene silencing pathways. The majority of expected RNAi was found in the nucleus, which is important site of gene silencing actions. The gene ontology (GO) enrichment analysis revealed some important molecular functions (MFs) and biological processes (BPs) including RNA interference that were related to the predicted RNAi genes which directly involved in the gene silencing mechanism. Gene regulatory network (GRN) analysis identified some important transcription factors including PAZ, and SNF2 involved in RNAi techniques and micro RNAs (miRNAs) including Pda-MIR156b, Pda-MIR396a, Pda-MIR166a, Pda-MIR167d, Pda-MIR395e, Pda-MIR529a associated with biotic/abiotic stress tolerance and developments, as transcriptional and post-transcriptional regulators of RNAi genes. The cis-acting regulatory element analysis suggested some vital cis-acting elements (as-1, ABRE, MBS, MYB, MYC, Box-4, G-box, I-box, STRE) that linked with the predicted RNAi as different abiotic stresses. Therefore, the findings of this study would be useful resources for further research to improve the date palm production.