bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kill your ancestors
Authors: Sanchez Andrew 
Published: July 2023

AbstractThis essay explains why debates about the decolonization of anthropology tend to become reactive and confrontational, and outlines a model for why productive critique is central to intellectual progress. In a small, young discipline that values subjectivity and the questioning of ethnocentrism, the decolonial critique of tradition is more likely to be felt as a personalized war on one's professional community and sense of self. Further, the tendency toward factionalism in anthropology is driven by an emphasis on charismatic and individualistic intellectual work. The essay argues that decolonization should not be conceived as a discrete generational war that can be definitively won. Rather, it should be understood as an ongoing collective transformation that expresses the logics of social progress and is consistent with the ethnographic imperative.
Selective use of radiological staging in node‐positive stage II breast cancer patients may have a role in treatment
Authors: Leem Chaey , Wang Yijiao , Kirkpatrick Joshua , Juhasz Eva 
Published: July 2023

AbstractBackgroundAdvanced‐staging radiography is used inconsistently for patients with early‐stage (stage I + II) breast cancer. However, accurate and appropriate staging of newly diagnosed breast cancer may significantly impact treatment decisions.MethodsFour hundred and ninety‐nine patients with stages II and III breast cancer were seen in the breast service at Waitemata DHB, New Zealand from 2013 to 2018 were enrolled in the study and audited for radiological staging.ResultsOne hundred and two stage II patients had computed tomography (CT) at baseline; 88 of 102 (86%) of stage II patients were node‐positive (≥N1) with six patients (6.8%) having distant metastatic disease, and were upstaged to stage IV. Fifty‐two stage III patients out of 72 (72%) had baseline staging CTs. Nine out of 52 patients (17%) of stage III patients were upstaged to stage IV. Despite guideline recommendations, baseline staging for T4 disease (stage IIIB) was poor, with only 7 out of 13 patients with stage IIIB disease radiologically staged.ConclusionConsideration for baseline radiological staging should be given to stages II and III, cN1 breast cancer patients, in which diagnosis of distant metastatic disease would change the treatment plan. Regional guidelines for baseline radiological staging for breast cancer patients may have an impact on patient management in breast cancer patients.
The public health theory of populism
Authors: Di Nucci Ezio 
Published: July 2023

AbstractSuccessful public health interventions have, in recent decades, improved the health of the working classes in significant ways across much of the western world. Nevertheless, here, I argue that populist electoral breakthroughs over the last decade may be considered side‐effects of ‘successful’ public health policies: crucially, the claim is that those political side‐effects resulted because of—rather than despite—the health‐measured success of those public health interventions.
S&P 500 volatility, volatility regimes, and economic uncertainty
Authors: Adrangi Bahram , Chatrath Arjun , Raffiee Kambiz 
Published: July 2023

AbstractWe assess the relationship between regime‐dependent volatility in S&P 500, economic policy uncertainty, the S&P 500 bull and bear sentiment spread (bb_sp), as well as the Chicago Board Options Exchange's VIX over the period 2000–2018. Our findings from two‐covariate GARCH–MIDAS (GM) methodology, regime switching Markov Chain, and quantile regressions suggest that the association of realized volatility and sentiment varies across high‐ and low‐volatility regimes and depends on investors’ sensitivity toward incidents of market uncertainties under these regimes. The findings suggest that these indicators may not be useful in volatility forecasting, especially under high‐volatility regimes.
Impact of early introduction of biologics on internal medications for neuromyelitis optica spectrum disorder
Authors: Sakurai Kenzo , Isahaya Kenji , Imai Takeshi , Yamano Yoshihisa 
Published: July 2023

AbstractObjectivesNeuromyelitis optica spectrum disorder (NMOSD) can cause severe disability after a single attack. This study aimed to investigate the reduction of oral medications, including steroids, in patients using biologics within 1 year after the onset or relapse of NMOSD.MethodsPatients with NMOSD who were using biologics and attending the Department of Neurology at St. Marianna University School of Medicine from November 2019 to February 2023 were enrolled. The patients were introduced to biologics within 1 year of their last relapses. The study examined whether these patients experienced clinical relapse, changes in prednisolone dosage of 5 mg/day or less and changes in the number of oral medications.ResultsA total of 14 patients were included. The mean prednisolone dosage was 17.5 ± 5.8 mg/day, and the mean number of medications was 6.2 ± 4.2. No relapse was reported in any patient after the introduction of biologics. The prednisolone dosage gradually decreased to 5.3 ± 2.9 mg/day and 3.1 ± 1.7 mg/day at 6 and 12 months, respectively, and the rates of achieving a prednisolone dosage of ≤5 mg/day at 6 and 12 months were 61.5% and 100%, respectively. The total number of medications decreased to 4.4 ± 4.6.ConclusionsBiologics can be introduced early after NMOSD relapse to reduce prednisolone dosage and counteract polypharmacy. The high relapse prevention rate of biologics makes them a valuable option for preventing relapse in patients with NMOSD.
Effects of minocycline on dendrites, dendritic spines, and microglia in immature mouse brains after kainic acid‐induced status epilepticus
Authors: Yang Xiaoyue , Li Tianyi , Liu Jie , Sun Hong , Cheng Li , Song Xiaojie , Han Ziyao , Luo Hanyu , Han Wei , Xie Lingling , Jiang Li 
Published: July 2023

AbstractPurposeThis study aimed to investigate whether minocycline could influence alterations of microglial subtypes, the morphology of dendrites and dendritic spines, the microstructures of synapses and synaptic proteins, or even cognition outcomes in immature male mice following status epilepticus (SE) induced by kainic acid.MethodsGolgi staining was performed to visualize the dendrites and dendritic spines of neurons of the hippocampus. The microstructures of synapses and synaptic proteins were observed using transmission electron microscopy and western blotting analysis, respectively. Microglial reactivation and their markers were evaluated using flow cytometry. The Morris water maze (MWM) test was used to analyze spatial learning and memory ability.ResultsSignificant partial spines increase (predominate in thin spines) was observed in the dendrites of neurons after acute SE and partial loss (mainly in thin spines) was presented by days 14 and 28 post‐SE. The postsynaptic ultrastructure was impaired on the 7th and 14th days after SE. The proportion of M1 microglia increased significantly only after acute SE Similarly, the proportion of M2 microglia increased in the acute stage with high expression levels of all surface markers. In contrast, a decrease in M2 microglia and their markers was noted by day 14 post‐SE. Minocycline could reverse the changes in dendrites and synaptic proteins caused by SE, and increase the levels of synaptic proteins. Meanwhile, minocycline could inhibit the reactivation of M1 microglia and the expression of their markers, except for promoting CD200R. In addition, treatment with minocycline could regulate the expression of M2 microglia and their surface markers, as well as ameliorating the impaired spatial learning and memory on the 28th day after SE.ConclusionsDendritic spines and microglia are dynamically changed after SE. Minocycline could ameliorate the impaired cognition in the kainic acid‐induced mouse model by decreasing the damage to dendrites and altering microglial reactivation.
The engagement of autophagy in maniac disease
Authors: Yang Yidong , Yuan Renxiang , Lu Yangyang , Zhu Chenze , Zhang Chen , Lue Haifeng , Zhang Xiangnan 
Published: July 2023

AbstractAimsMania is a prevalent psychiatric disorder with undefined pathological mechanism. Here, we reviewed current knowledge indicating the potential involvement of autophagy dysregulation in mania and further discussed whether targeting autophagy could be a promising strategy for mania therapy.DiscussionsAccumulating evidence indicated the involvement of autophagy in the pathology of mania. One of the most well‐accepted mechanisms underlying mania, circadian dysregulation, showed mutual interaction with autophagy dysfunction. In addition, several first‐line drugs for mania therapy were found to regulate neuronal autophagy. Besides, deficiencies in mitochondrial quality control, neurotransmission, and ion channel, which showed causal links to mania, were intimately associated with autophagy dysfunction.ConclusionsAlthough more efforts should be made to either identify the key pathology of mania, the current evidence supported that autophagy dysregulation may act as a possible mechanism involved in the onset of mania‐like symptoms. It is therefore a potential strategy to treat manic disorder by correting autophagy.
Tax Incentives and Maturity Mismatch between Investment and Financing: Evidence from China
Authors: Feng Qianbin , Zhao Lexin , Xu Mingxue 
Published: July 2023

AbstractThis paper examines the effects of China's accelerated depreciation policy (ADP) on the maturity mismatch between investment and financing. Using panel data for China's A‐share nonfinancial listed companies from 2010 to 2019 and a staggered difference‐in‐differences approach, we found the following. First, ADP significantly aggravated the degree of corporate maturity mismatch, and this result was robust across multiple checks. Second, due to an insufficient long‐term loan supply, firms had to finance the fixed investments induced by ADP with short‐term debts, leading to maturity mismatches. Third, the positive policy effects were mainly significant for firms with high policy exposure, high‐risk preferences, a high degree of information asymmetry, and firms with weak long‐term financing capacity. Finally, maturity mismatch exacerbated corporate financial risks. Our research findings indicate that passive maturity mismatch is prevalent among Chinese companies and emphasize the need to address financial repression in order to mitigate the potential financial risks that may arise from tax incentives.
Measuring alcohol use among adolescents in Africa: A systematic scoping review of consumption, screening and assessment tools
Authors: Seekles Maaike L. , Briegal Eleanor , Biggane Alice M. , Obasi Angela I. 
Published: July 2023

AbstractIssuesGlobally, adolescent drinking is a major public health concern. Alcohol measurements are influenced by local consumption practices, patterns and perceptions of alcohol‐related harm. This is the first review to examine what tools are used to measure alcohol consumption, or screen for or assess harmful use in African adolescents, and how these tools take into account the local context.ApproachA systematic scoping review was conducted in line with the Arksey and O'Malley framework. A search in MEDLINE, CINAHL, Global Health and the Cochrane Database covered the period of 2000–2020.Key FindingsThe search identified 121 papers across 25 African countries. A range of single‐ and multi‐item tools were identified. Very few adaptations of existing questions were specified, and this search identified no tools developed by local researchers that were fundamentally different from established tools often designed in the USA or Europe. Inconsistencies were found in the use of cut‐off scores; many studies used adult cut‐off scores.Implications and ConclusionThe possible impact of African drinking practices and culture on the accuracy of alcohol screening tools is currently unknown, but is also not taken into account by most research. This, in combination with a limited geographical distribution of alcohol‐related research across the continent and inconsistent use of age‐ and gender‐specific cut‐off scores, points towards probable inaccuracies in current data on adolescent alcohol use in Africa.
RNF216 affects the stability of STAU2 in the hypothalamus
Authors: Yang Han , Zhu Yong , Li Xin , Jiang Zuiming , Dai Wenting 
Published: July 2023

AbstractIdiopathic hypogonadotropic hypogonadism (IHH) is a rare disease characterized by gonadal failure due to deficiency in gonadotropin‐releasing hormone (GnRH) synthesis, secretion, or action. RNF216 variants have been recently identified in patients with IHH. Ring finger protein 216 (RNF216), as a ubiquitin E3 ligase, catalyzes the ubiquitination of target proteins with high specificity, which consequently modulates the stability, localization, and interaction of the target protein. In this study, we found that RNF216 interacted with Staufen2 (STAU2) and affected the stability of STAU2 through the ubiquitin–proteasome pathway. STAU2, as a double‐stranded RNA‐binding protein enriched in the nervous system, plays a role in RNA transport, RNA stability, translation, anchoring, and synaptic plasticity. Further, we revealed that STAU2 levels in the hypothalamus of RNF216−/− mice were increased compared with wild‐type (WT) mice. The change in STAU2 protein homeostasis may affect a series of RNA cargoes. Therefore, we analyzed the changes in RNA levels in the hypothalamus of RNF216−/− mice and WT mice by RNA sequencing. We found that deletion of RNF216 led to decreased activities of the prolactin signaling pathway, neuroactive ligand–receptor interaction, GnRH signaling pathway, and ovarian steroidogenesis. The weakening of these signal pathways is likely to affect the secretion of GnRH, thereby affecting the development of gonads. Therefore, our study suggests that STAU2 may be a potential therapeutic target for IHH. Further experiments are needed to demonstrate the association between the weakening of these signaling pathways and the RNA‐binding protein STAU2.
Geographies of queer economies
Authors: Rush‐Morgan Rowan 
Published: July 2023

AbstractThis paper provides a critical overview of research in geography that has explored the economic lives of Lesbian, gay, bisexual, transgender and queer (LGBTQ+) individuals. I begin by considering how the consumption and production of mainstream commercial gaybourhoods is the primary approach through which geographies of sexuality, and queer geographies have engaged with economy. I then examine the ways in which digital spaces have blurred the boundaries of consumption and production, arguing that digital spaces are indicative of the much broader range of economic actions in which LGBTQ+ people take part. Finally, I turn to Gibson‐Graham's ‘diverse economies’, suggesting that this concept can attend to the existence of numerous multi‐scalar and overlapping queer economies. Developing a queer economies research agenda is crucial to turn attention beyond consumption and production in a narrow range of gaybourhoods, and to better portray the lives of those frequently excluded from mainstream commercial LGBTQ+ economies.
Impact of the COVID‐19 pandemic on the primary lung cancer screening program in Akita Prefecture, a region with the fastest aging population in Japan
Authors: Okuda Yuji , Sato Kazuhiro , Asano Mariko , Kudoh Kentaroh , Omoto Eiki , Izumiya Yuka , Sakamoto Sho , Takeda Masahide , Shimizu Tatsunori , Ota Hidetaka , Kurokawa Hirokazu , Minamiya Yoshihiro , Nakayama Katsutoshi 
Published: July 2023

AimAkita Prefecture has the largest proportion of older inhabitants and the highest cancer mortality rate in Japan. Lung cancer is one of the biggest killers, and early detection is critical. Chest X‐ray examinations are the main screening method for lung cancer; however, the COVID‐19 pandemic has affected the screening system. Here, we evaluate how COVID‐19 has affected lung cancer screening in Akita Prefecture.MethodsUsing the Akita General Health Corporation database, the average annual number of chest X‐ray screening tests, close examinations and lung cancer diagnoses (stratified by sex and age) was evaluated during 2016–2019, and compared with the 2020 values. Furthermore, data on lung cancer registrations from 2018 to 2020 were obtained from the Collaborative Akita Prefecture Hospital‐Based Cancer Registration System and analyzed.ResultsThe average annual number of screening tests, close examinations and lung cancer diagnoses declined (by >50%) between 2016 to 2019 and 2020, especially among older people (aged ≥65 years). Furthermore, by stage, the number of patients with early‐stage lung cancer (stage 0–I) decreased, and the number with advanced‐stage cancer (stage IV) increased.ConclusionsThe COVID‐19 pandemic reduced lung cancer screening participation, especially among the older adult population in Akita Prefecture, resulting in a decrease in lung cancer diagnoses through screening. This might have reduced the number of early‐stage cancer registrations. It is necessary to improve health education among the public regarding the importance of chest X‐ray screening. Geriatr Gerontol Int 2023; 23: 622–627.
Evaluating von Willebrand factor and ADAMTS13 levels in thalassemia major patients and assessing a possible association with Thrombospondin‐1
Authors: Al‐Sabaan Kefayah , Al‐Awadhi Anwar 
Published: July 2023

AbstractIntroductionAlterations in the endothelium and endothelial adhesion proteins such as von Willebrand factor (vWF) play major roles in hypercoagulability in thalassemia. vWF protein release leads to platelet aggregation and thrombi formation at the site of vascular injury. It is then degraded by the proteolytic enzyme ADAMTS13. Thrombospondin‐1 is a multifactorial glycoprotein, which was reported to compete with ADAMTS13 for sites of vWF proteolysis. In this study, levels of vWF, ADAMTS13, and TSP‐1 proteins were determined in β‐thalassemia major patients. A possible association between TSP‐1 and vWF and ADAMTS‐13 was also evaluated.MethodsThe study was conducted on 80 β‐thalassemia major patients and 80 age and sex matched healthy controls. The 80 patients were sub‐divided into two groups; splenectomised and non‐splenectomised. vWF, ADAMTS13 and TSP‐1 plasma level were measured using ELISA technique.ResultsThere was no significant difference in vWF and TSP‐1 levels between patients and controls (p > 0.05). However, ADAMTS13 levels and ADAMTS13 activity/vWF antigen ratio were significantly higher in patients compared to controls (p < 0.05). VWF antigen and TSP‐1 level were significantly higher in splenectomised patients (p = 0.025 and p < 0.001, respectively). We also observed a significant decrease in ADAMTS13 activity/vWF antigen ratio among splenectomised compared to non‐ splenectomised patients (p = 0.019). Correlation analysis showed a significant negative correlation between TSP‐1 and vWF Collagen Binding Activity (r = −0.394, p = 0.021) and a positive correlation with ADAMTS13 activity/vWF antigen ratio (r = 0.356, p = 0.039) in splenectomised compared to non‐ splenectomised patients.ConclusionOur findings highlight the adequacy of patient management protocols for β‐TM in Kuwait as patients presented with comparable levels of platelets, vWF and TSP‐1 compared to normal controls. The reported increase in ADAMTS13 in patients may be required to maintain normal levels of vWF. Although no active thrombotic episodes were reported at the time of the study, the significant rise in platelets, vWF:Ag and TSP‐1 levels in splenectomised patients may indicate a tendency towards hypercoagulability. Monitoring of splenectomised patients is recommended.
AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME‐conferred pyroptosis in non‐small cell lung cancer
Authors: Chen Lian‐kuai , Lin Shu‐ping , Xie Yong‐huan , Tan Xiang‐peng , Xiong Ben‐han , Zeng Xiang‐feng , Zhu Cai‐rong , Cao Shao‐yi , Ye Xiao‐yan , Liu Hong‐jiao , Wu Xiao‐ping 
Published: July 2023

AbstractNon‐small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer. Cisplatin is commonly used in the treatment of many malignant tumours including NSCLC. The innate drug sensitivity greatly affects the clinical efficacy of cisplatin‐based chemotherapy. As a plasma membrane adhesion molecule, amphoterin‐induced gene and ORF‐2 (AMIGO2) initially identified as a neurite outgrowth factor has been recently found to play a crucial role in cancer occurrence and progression. However, it is still unclear whether AMIGO2 is involved in innate cisplatin sensitivity. In the present study, we provided the in vitro and in vivo evidences indicating that the alteration of AMIGO2 expression triggered changes of innate cisplatin sensitivity as well as cisplatin‐induced pyroptosis in NSCLC. Further results revealed that AMIGO2 might inhibit cisplatin‐induced activation of (caspase‐8 and caspase‐9)/caspase‐3 via stimulating PDK1/Akt (T308) signalling axis, resulting in suppression of GSDME cleavage and the subsequent cell pyroptosis, thereby decreasing the sensitivity of NSCLC cells to cisplatin treatment. The results provided a new insight that AMIGO2 regulated the innate cisplatin sensitivity of NSCLC through GSDME‐mediated pyroptosis.
Board gender diversity and acquisition choices
Authors: Gunasekarage Abeyratna , Khedmati Mehdi , Minnick Kristina , Shams Syed 
Published: July 2023

AbstractWe investigate the influence of gender diversity on the acquisition choices of bidding firms and find that firms with greater gender diversity are more likely to acquire nonlisted targets, use cash as the method of payment, and purchase firms in similar industries. Results show that these preferences are significantly influenced by female directors' financial expertise, target industry experience, mergers and acquisitions (M&A) experience, academic and professional qualifications, and networks. The percentage of female directors on boards is positively correlated with the market response to the announcement of acquisition choices preferred by female directors. Furthermore, bidders improve efficiency and accumulate long‐term value gains through the contributions made by their female directors to these acquisition choices.
Financial analysts' bundling across firms: Target prices and stock recommendations
Authors: Chen Yu‐An , Palmon Dan 
Published: July 2023

AbstractA rising trend is that analysts bundle earnings forecasts for multiple firms on the same day, and such forecast bundling is associated with low‐quality forecasts. We explore target price bundling and recommendation bundling. Factors driving bundling revisions of an output for multiple firms vary across three outputs: forecasts, target prices, and recommendations. Target price (recommendation) revisions bundled for firms are less informative than stand‐alone revisions. Although consistency in the direction of revisions between different outputs is typically associated with higher perceived quality, consistent revisions between outputs are not associated with higher informativeness of revisions bundled for multiple firms.