bluuebunny/crossref_metadata_2025_split huggingface dataset:
A joinpoint and age–period–cohort analysis of ocular cancer secular trends in Iran from 2004 to 2016
Authors: Abolhosseini Mohammad , Khorrami Zahra , Safi Sare , Akbari Mohammad Esmaeil , Moshtaghion Seyed Mohamadmehdi , Mohammadi Seyed Farzad , Kanavi Mozhgan Rezaei , Karimi Saeed 
Published: January 2023

AbstractInvestigating secular trends of ocular cancer registration in Iran. After acquiring Iranian national population-based cancer registry data, trends of age-standardised incidence rates (ASIR) of ocular cancers and annual percent changes (APC) between 2004 and 2016 were analysed in age groups, gender, topography and morphology types with joinpoint regression analysis. Age, period, and cohort effects on incidence rates were estimated by age–period–cohort model. Geographic distribution of ASIR was assessed using GIS. Overall ASIR of ocular cancers was 16.04/100,000 (95% CI 15.77–16.32). Joinpoint regression analysis showed a significant increase of ASIR between 2004 and 2009 for males (APC = 5.5, 95% CI  0.9–10.2), ages over 50 years (APC = 5.2, 1.2–9.4), skin/canthus/adnexal cancers (APC = 4.2, 0.8–7.7), and carcinomas/adenocarcinomas (APC = 4.3, 0.6–8.1); however, between 2009 and 2016 a declining trend was observed in all investigated variables. ASIR of retinoblastoma was significantly increased (averaged APC = 20.7, 9–33.7) between 2004 and 2016. age–period–cohort analyses showed that incidence rates of ocular cancers significantly increased with aging, time periods, and birth cohort effects (p < 0.001). ASIR varied from 6.7/100,000 to 21.7/100,000 in Iran. Excepting retinoblastoma, all ocular cancer incidence trends were downward over a 13-year period; however, it was increasing between 2004 and 2009 cancer. ASIR was significant aging in Iran.
Squeezed states generation by nonlinear plasmonic waveguides: a novel analysis including loss, phase mismatch and source depletion
Authors: Nadgaran Hamid , Izadi Mohammad Amin , Nouroozi Rahman 
Published: January 2023

AbstractIn this article, a full numerical method to study the squeezing procedure through second harmonic generation process is proposed. The method includes complex nonlinear coupling coefficient, phase mismatch, and pump depletion. Attention has been also paid to the effects of accumulated noises in this work. The final form of the numerical formula seems to be much simpler than the analytical solutions previously reported. The function of this numerical method shows that it works accurately for different mechanisms of squeezed state generations and does not suffer from instabilities usually encountered even for non-uniform, coarse steps. The proposed method is used to examine the squeezing procedure in an engineered nonlinear plasmonic waveguide. The results show that using the nonlinear plasmonic waveguide, it is possible to generate the squeezed states for the pump and the second harmonic modes with high efficiency in a propagation length as short as 2 mm which is much shorter than the needed length for the traditional nonlinear lithium niobate- based optical waveguides being of the order of 100 mm. This new method of squeezed states generation may find applications in optical communication with a noise level well below the standard quantum limit, in quantum teleportation, and in super sensitive interferometry.
Genome-wide identification and expression profile of Elovl genes in threadfin fish Eleutheronema
Authors: Xiao Jie , Wang Wen-Xiong 
Published: January 2023

AbstractLong-chain polyunsaturated fatty acids (LC-PUFA), including eicosapentaenoic acid and docosahexaenoic acid, are the essential fatty acids for organs to maintain various biological functions and processes. The threadfin fish Eleutheronema, with its rich nutritional value especially the high fatty acid contents, has become one of the promising aquaculture species in China and the potential food source of fatty acids for human consumption. However, the molecular basis underlying the biosynthesis of fatty acids in Eleutheronema species is still unknown. The elongation of the very long-chain fatty acids (Elovl) gene family in fish plays several critical roles in LC-PUFA synthesis. Therefore, in the present study, we performed genome-wide identification of the Elovl gene family to study their evolutionary relationships and expression profiles in two threadfin fish species Eleutheronema tetradactylum and Eleutheronema rhadinum, the first representatives from the family Eleutheronema. Phylogenetic analysis revealed that the Elovl genes in Eleutheronema were classified into six subfamilies (elovl1a/1b, elovl4a/4b, elovl5, elovl6/6 l, elovl7a, elovl8b). Phylogenetic, gene structure, motif, and conserved domain analysis indicated that the Elovl genes were highly conserved within the same subfamily in Eleutheronema. In addition, the Elovl genes were distributed in 7/26 chromosomes, while the duplicated gene pair, elovl4a and elovl4b, showed collinear relationships. The predicted secondary structure patterns and the 3D models revealed the highly similar functions and evolutionary conserved structure of Elovl proteins in Eleutheronema. The selection pressure analysis revealed that Elovl genes underwent strong purifying selection during evolution, suggesting that their functions might be evolutionarily conserved in Eleutheronema. Additionally, the expression patterns of Elovl genes in different tissues and species were distinct, indicating the possible functional divergence during evolution in the Eleutheronema genus. Collectively, we provided the first comprehensive genomic information on Elovl genes in threadfin fish Eleutheronema. This study enhanced the understanding of the underlying mechanisms of fatty acids biosynthesis in Eleutheronema, and provided new insights on breeding new varieties of fatty acids-enriched fish with potential benefits to farmers and the health of consumers.
Learning the protein language of proteome-wide protein-protein binding sites via explainable ensemble deep learning
Authors: Hou Zilong , Yang Yuning , Ma Zhiqiang , Wong Ka-chun , Li Xiangtao 
Published: January 2023

AbstractProtein-protein interactions (PPIs) govern cellular pathways and processes, by significantly influencing the functional expression of proteins. Therefore, accurate identification of protein-protein interaction binding sites has become a key step in the functional analysis of proteins. However, since most computational methods are designed based on biological features, there are no available protein language models to directly encode amino acid sequences into distributed vector representations to model their characteristics for protein-protein binding events. Moreover, the number of experimentally detected protein interaction sites is much smaller than that of protein-protein interactions or protein sites in protein complexes, resulting in unbalanced data sets that leave room for improvement in their performance. To address these problems, we develop an ensemble deep learning model (EDLM)-based protein-protein interaction (PPI) site identification method (EDLMPPI). Evaluation results show that EDLMPPI outperforms state-of-the-art techniques including several PPI site prediction models on three widely-used benchmark datasets including Dset_448, Dset_72, and Dset_164, which demonstrated that EDLMPPI is superior to those PPI site prediction models by nearly 10% in terms of average precision. In addition, the biological and interpretable analyses provide new insights into protein binding site identification and characterization mechanisms from different perspectives. The EDLMPPI webserver is available at http://www.edlmppi.top:5002/.
Fused diethynylbenzenes and phenanthrenes via arynes with alkynylsilanes
Authors: Dong Jie , Lei Yu , Hu Qiong , Zong Lingli , Zhang Ke , Zhang Yajuan , Hu Yimin 
Published: January 2023

The concept of organosilicon in organic synthesis is applied to the hydroalkynylation and base promoted intramolecular cyclization reactions of hexadehydro-Diels–Alder-derived benzynes.
Sensory-Processing Sensitivity Predicts Fatigue From Listening, But Not Perceived Effort, in Young and Older Adults
Authors: McGarrigle Ronan , Mattys Sven 
Published: January 2023

Purpose:
Listening-related fatigue is a potential negative consequence of challenges experienced during everyday listening and may disproportionately affect older adults. Contrary to expectation, we recently found that increased reports of listening-related fatigue were associated with better performance on a dichotic listening task. However, this link was found only in individuals who reported heightened sensitivity to a variety of physical, social, and emotional stimuli (i.e., increased “sensory-processing sensitivity” [SPS]). This study examined whether perceived effort may underlie the link between performance and fatigue.

Method:
Two hundred six young adults, aged 18–30 years (Experiment 1), and 122 older adults, aged 60–80 years (Experiment 2), performed a dichotic listening task and were administered a series of questionnaires including the NASA Task Load Index of perceived effort, the Vanderbilt Fatigue Scale (measuring daily life listening-related fatigue), and the Highly Sensitive Person Scale (measuring SPS). Both experiments were completed online.

Results:
SPS predicted listening-related fatigue, but perceived effort during the listening task was not associated with SPS or listening-related fatigue in either age group. We were also unable to replicate the interaction between dichotic listening performance and SPS in either group. Exploratory analyses revealed contrasting effects of age; older adults found the dichotic listening task more effortful but indicated lower overall fatigue.

Conclusions:
These findings suggest that SPS is a better predictor of listening-related fatigue than performance or effort ratings on a dichotic listening task. SPS may be an important factor in determining an individual's likelihood of experiencing listening-related fatigue irrespective of hearing or cognitive ability.

Supplemental Material:

https://doi.org/10.23641/asha.21893013
The Efficacy and Safety of a Low-Dose Tranexamic Acid Bolus-Only Protocol Compared with the Moderate-Dose Protocol in Valvular Heart Surgery
Authors: Koster Andreas , Hulde Nikolai , Deutsch Marcus-Andre , Gummert Jan F. , von Dossow Vera , Zittermann Armin 
Published: January 2023

AbstractIn 873 propensity score–matched pairs of patients undergoing valvular heart surgery, we compared a “moderate dose” of tranexamic acid (TXA) protocol (group 1; median TXA dose: 24 mg/kg body weight) with a 1.5-g “bolus-only” protocol (group 2; median TXA dose: 19 mg/kg body weight). The number of transfused patients was higher in group 2 than in group 1 (74.5 vs 66.0%, p < 0.001), as was the number of transfused red blood cell concentrates (p = 0.001). The risks of re-exploration and convulsive seizures were similar between groups (p > 0.50). Data indicate an impaired efficacy following the “bolus-only” protocol, without a significant safety improvement.
Inflammatory Bowel Disease and Colorectal Cancer
Authors: Glyn Tamara , Lightner Amy L. 
Published: January 2023

AbstractThe prevalence of inflammatory bowel disease (IBD) continues to rise with the increasing rates in the developing world and the improving longevity of IBD patients. A diagnosis of colonic IBD is associated with an increased risk of colorectal cancer (CRC) and this accounts for approximately 15% of the estimated mortality from IBD. CRC in IBD appears to be a pathologically distinct entity and progress is being made to understand the unique components of this process with a view to better predicting outcomes and potentially improving surveillance, treatments, and eventually modifying risk. In the interim, patients are entered into surveillance programs designed to identify at-risk patients early and improve outcomes. Dramatic evolution of technology in this area has changed the landscape of surveillance and dysplasia management over the last decade and promises to continue to do so. This review aims to provide a contemporary overview of IBD-associated CRC in terms of its epidemiology, pathogenesis, surveillance, and management.
Sharia compliance, national governance, and value of cash in Organization of Islamic Cooperation countries
Authors: Chen Naiwei , Yu Min-Teh 
Published: January 2023

AbstractThis study examines whether and how Sharia compliance and national governance affect the value of corporate cash holding (cash) in Organization of Islamic Cooperation (OIC) countries. Study results indicate that cash can enhance firm value and such cash value is higher for Sharia-compliant firms than for Sharia non-compliant firms. In addition, cash is particularly valuable when national governance is strong. Furthermore, the positive effect of Sharia compliance on cash value is more pronounced when national governance is strong. Results suggest that internal governance (i.e., Sharia compliance) and external governance (i.e., national governance) should be in sync to maximize cash value.
Physics-based simulations of grassfire propagation on sloped terrain at field scale: motivations, model reliability, rate of spread and fire intensity†
Authors: Innocent Jasmine , Sutherland Duncan , Khan Nazmul , Moinuddin Khalid 
Published: January 2023

This study focuses on physics-based modelling of grassfire behaviour over flat and sloped terrains through a set of field-scale simulations performed using the Wildland–urban Interface Fire Dynamics Simulator (WFDS), with varying wind speeds (12.5, 6 and 3 m s−1) and slope angles (−30° to +30°). To ensure the accuracy of this Large Eddy Simulation (LES), a sensitivity study was carried out to select the converged domain and grid sizes. Fire isochrones, locations of fire front, dynamic and quasi-steady rates of spread (RoS), and fire intensity results from the simulations are presented. Within the simulations conducted, the RoS and fire intensity were found to be higher with increasing slope angles, as well as with wind velocity. RoS comparisons are made with various empirical models. At different slope angles and driving wind velocities, different empirical quasi-steady RoS broadly match with particular dynamic maximum, minimum and averaged RoS values from this study. It appears that the ideal nature of grassfire propagation simulation and challenges related to measuring quasi-steady values in experimental studies are likely reasons for the observed differences. Additionally, for lower wind velocities, the RoS–fire intensity relationship (Byram’s) deviates from linearity for greater upslopes.
Space and time transformations with a minimal length
Authors: Bosso Pasquale 
Published: January 2023

Abstract
Phenomenological studies of quantum gravity have proposed a modification of the commutator between position and momentum in quantum mechanics to introduce a minimal uncertainty in position in quantum mechanics. In the present work, we show the influence of space and time transformations in shaping quantities such as momentum, energy, and their relations with the generators of transformations. Thus, such an influence determines, among other aspects, the time evolution of a quantum system. In the exemplary case of Galilean transformations, the Schrödinger equation is identical to the ordinary case.
Heisenberg uncertainty principle: an advanced undergraduate laboratory experiment based on quantum quadrature operators
Authors: Chen Yu , Liu Zhaoyang , Chen Xin , Liu Shuqi , Jiang Jiatong , Wu Yuan , Guo Jinxian , Chen L Q 
Published: January 2023

Abstract
The Heisenberg uncertainty principle (HUP) plays an important role in quantum mechanics. It is necessary to demonstrate this principle experimentally for undergraduates to understand HUP clearly. In this paper, we originally employ the quantum quadrature operators to demonstrate HUP in undergraduate laboratories. Starting from the quantization of electromagnetic field, we briefly review the definition of quadrature operators and demonstrate HUP via the variances of quadrature operators. And the scheme of HUP demonstration with homodyne detection is introduced. More importantly, we develop a tabletop experimental apparatus for the demonstration of HUP in undergraduate laboratories. Our proposal focuses on the basic quantum mechanics concepts, experimental principles, and instruction as well as experimental techniques. It provides a way to help undergraduates, especially the ones who will go on graduate study in quantum technology in the future, make connections between abstract quantum mechanics concepts and concrete experiments, which makes the concepts better understood.
3D printing-based microfluidic devices in fabric
Authors: Switalla Ander , Wentland Lael , Fu Elain 
Published: January 2023

Abstract
Fabric-based microfluidics is a growing sub-field of porous materials-based microfluidics. 3D printing has been demonstrated as a useful fabrication method for open channel microfluidic devices, and also in the context of porous substates such as cellulose. In the current report, we describe a straightforward method for 3D printing fabric-based microfluidic devices. We demonstrate the ability to create both full and partial barriers in fabric, characterizing minimum channel and barrier widths, as well as reproducibility of the method using the metric of flow time repeatability through the channels. We discuss considerations specific to 3D printing in fabric including fabric anisotropy, stretching, and nonuniformity. Further, we highlight our fabrication method via the implementation of a colorimetric urea assay.
On the design of piezoelectric actuator for 1D MEMS scanning mirror applications
Authors: Liu Shih-Chi , Cheng Hao-Chien , Chen Si-Han , Lin Hung-Yu , Hsu Chih-Chen , Shih Fuchi , Liang Kai-Chih , Wu Mingching , Fang Weileun 
Published: January 2023

Abstract
This study presents the design, implementation, and characterization of 1D resonant type micro-electro-mechanical-systems (MEMS) piezoelectric scanning mirrors with different actuator designs to investigate their influences on the figure of merits (FoMs) for automotive light detection and ranging application. The MEMS scanning mirrors are driven by lead zirconate titanate (PZT) thin film in this study owing to its outstanding piezoelectric properties. Three different beam-type piezoelectric actuators are designed, including the reference meander straight-beam actuator design, and the proposed meander curved-beam and straight-curved tapered beam actuator designs. Simulations show the scan angle enhancement for two proposed designs, yet the resonant scanning frequency of meander curved-beam design dropped to below the 2 kHz requirement. To evaluate the designs, scanning mirrors with two proposed actuators are fabricated and tested. Measurements show that the resonant frequencies for the two proposed MEMS scanning mirrors are 1735 Hz and 2578 Hz, respectively. Two proposed designs respectively have the maximum optical angles of 48.1° and 50.6° at the 20 Vpp driving voltage. Due to the much higher stress on the beam structure induced by the misalignment of PZT film, the actuator could not reach the predicted scanning angle of near 80°. In comparison of the two proposed designs, the straight-curved tapered beam actuator design could enhance the FoM for about 56%. In summary, the performances of piezoelectric MEMS scanning mirror can be improved by varying the designs of length and shape of actuator, and the distribution of PZT film on the suspended actuator is also a critical design concern.
Advances in nonlinear photonic devices based on lithium niobate waveguides
Authors: Wang Zijie , Wang Chunhua , Yu Huakang 
Published: January 2023

Abstract
The nonlinear optical waveguide is one of the essential components of modern photonic integrated circuits. A high-quality lithium niobate (LN) waveguide has recently become available due to advances in thin-film LN materials and the associated fabrication techniques. In the past few years, LN waveguide-based nonlinear photonic devices have been intensively investigated due to their ultra-low loss and large index-contrast features. Here we review the recent progress in LN waveguide-based nonlinear photonics devices, including both passive and active components. We believe that LN-based nonlinear photonic devices will make a profound impact on modern photonic society.
Passivation of oxygen vacancy defects in conductive ZnO nanoparticles via low-temperature annealing in NF3
Authors: Xu Keliang , Li Peng , Wang Shengyu , Ma Jiangang , Xu Haiyang , Liu Yichun 
Published: January 2023

Abstract
Oxygen vacancies (VO) often exist in wide-bandgap metal oxide semiconductors (MOSs) as deep-level defects and undermine the reliability of various optoelectronic devices based on MOSs. Conventional methods to passivate VO defects, such as high-temperature annealing or plasma treatment, can compromise device performance. This work demonstrates that passivation of VO defects in aluminum-doped ZnO (AZO) nanoparticles can be realized through low-temperature annealing (350 °C) in an NF3 atmosphere. After the NF3 annealing, the longitudinal optical phonon scattering mode in Raman spectroscopy, the visible light emission intensity in photoluminescence spectroscopy, and the oxygen deficiency-related peak in x-ray photoelectron spectroscopy decrease simultaneously, indicating the passivation of VO defects in AZO nanoparticles. As a result, AZO nanoparticles show higher visible light reflectance and better stability of electrical conductivity owing to the suppression of deep-level light absorption and gas molecule adsorption. This work also offers insights into the passivation mechanism of VO defects in MOSs.
Effect of deformation dependence and mirror nucleus corrections energy on multinucleon transfer reaction cross sections
Authors: Zhao Tian Liang , Bao Xiao Jun , Zhang Hong Fei 
Published: January 2023

Abstract
Multinucleon transfer reactions are currently a powerful way to synthesize neutron-rich nuclei. To explore the effect of nucleus deformation and mirror nucleus shell correction energy in the nucleus mass model on the calculation of multinucleon transfer reaction cross sections in the dinuclear system (DNS) model, three macroscopic microscopic mass models are selected and the transfer reaction cross sections are calculated for 136Xe+208Pb and 64Ni+238U by improved DNS model+GEMINI++, respectively. The mirror nucleus shell correction energy does not improve the accuracy of the cross section of the transfer reaction. The introduction of a different dependence of the Coulomb and surface energy on the deformation can improve the calculation of the transfer reaction cross section when the projectile and target nuclei are deformed nuclei.
Waiting time dependence of aging
Authors: Odagaki Takashi 
Published: January 2023

Abstract
Aging phenomena have been observed in many non-equilibrium systems such as polymers and glasses, where physical properties depend on the waiting time between the starting time of observation and the time when the temperature is changed. The aging is classified into two types on the basis of the waiting time dependence of an instantaneous relaxation time: When the relaxation time is always an increasing function of the waiting time, the aging is called Type I and when it depends on the protocol of the temperature change, the aging is called Type II. Aging of a random walk in three dimensions is investigated when the free energy landscape controlling the jump rate responds to temperature change with a delay. It is shown that the intermediate scattering function of the random walk model exhibits Type II aging. It is also shown that the relaxation time of the free energy landscape can be deduced from the waiting time dependence of the instantaneous relaxation time.