bluuebunny/crossref_metadata_2025_split huggingface dataset:
The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops
Authors: de Amorim Julia L. , Leung Sara W. , Haji-Seyed-Javadi Ramona , Hou Yingzi , Yu David S. , Ghalei Homa , Khoshnevis Sohail , Yao Bing , Corbett Anita H. 
Published: April 2023

AbstractThe RNA exosome is a ribonuclease complex that mediates both RNA processing and degradation. This complex is evolutionarily conserved, ubiquitously expressed, and required for fundamental cellular functions, including rRNA processing. The RNA exosome plays roles in regulating gene expression and protecting the genome, including modulating the accumulation of RNA-DNA hybrids (R-loops). The function of the RNA exosome is facilitated by cofactors, such as the RNA helicase MTR4, which binds/remodels RNAs. Recently, missense mutations in RNA exosome subunit genes have been linked to neurological diseases. One possibility to explain why missense mutations in genes encoding RNA exosome subunits lead to neurological diseases is that the complex may interact with cell- or tissue-specific cofactors that are impacted by these changes. To begin addressing this question, we performed immunoprecipitation of the RNA exosome subunit, EXOSC3, in a neuronal cell line (N2A) followed by proteomic analyses to identify novel interactors. We identified the putative RNA helicase, DDX1, as an interactor. DDX1 plays roles in double-strand break repair, rRNA processing, and R-loop modulation. To explore the functional connections between EXOSC3 and DDX1, we examined the interaction following double-strand breaks, and analyzed changes in R-loops in N2A cells depleted for EXOSC3 or DDX1 by DNA/RNA immunoprecipitation followed by sequencing (DRIP-Seq). We find that EXOSC3 interaction with DDX1 is decreased in the presence of DNA damage and that loss of EXOSC3 or DDX1 alters R-loops. These results suggest EXOSC3 and DDX1 interact during events of cellular homeostasis and potentially suppress unscrupulous expression of genes promoting neuronal projection.
A multi-dimensional selective landscape drives adaptive divergence between and within closely relatedPhloxspecies
Authors: Goulet-Scott Benjamin E. , Farnitano Matthew C. , Brown Andrea L. M. , Hale Charles O. , Blumstein Meghan , Hopkins Robin 
Published: April 2023

AbstractNatural selection shapes diversity across micro and macro-evolutionary scales. Selection causes local adaptation across populations within species and is simultaneously responsible for much of the divergence between species. However, it is unclear if either the force of or the response to selection is the same or different across these scales. Here we show that natural selection drives adaptive divergence between closely related species in a pattern that is distinct from local adaptation within a species. We use reciprocal common-garden transplant experiments across three species ofPhloxwildflowers to show widespread adaptive divergence causing species to have highest fitness in their native habitats. Using provenance trials, we also find that one of thesePhloxspecies has strong local adaptation between populations. We compare the axes of divergence and selection between these two scales of diversity and discover that one suite of traits predicts fitness differences between species and that an independent suite of traits predicts fitness variation within species across individuals. Our work reveals how forces of selection can both drive key divergence between species, allowing for and causing speciation, while simultaneously causing extensive diversity that is maintained across populations within a species. The selection landscape is complex and multidimensional
Enhancing employee advocacy of the firm's corporate social responsibility (CSR) activities
Authors: Chomvilailuk Rojanasak , Butcher Ken 
Published: April 2023

PurposeThe paper aims to investigate how perceived psychological benefits from employee participation in corporate social responsibility activities affect organizational citizenship behavior across two Asia–Pacific countries with different national cultures.Design/methodology/approachA stakeholder relationship model, based on social exchange theory, underpinned the investigation that also tested the mediating role of organizational pride. In a cross-cultural context, data were collected from 319 full-time employees in Thailand and the US and analyzed with SEM-PLS.FindingsAnticipated psychological benefits of hedonic value and perceived community value were found to be significant antecedents of organizational citizenship behaviors, operationalized as customer-directed CSR advocacy. Organizational pride played a partial mediating role.Originality/valueThis study addresses a lack of micro-level CSR research into the relationship between psychological benefits of employee participation in CSR and organizational citizenship behavior. Specifically, this is the first study to link CSR drivers with customer-directed employee advocacy of the firms CSR activities. The study is also the first to compare relationships between an Asian and Western context for CSR drivers of organizational citizenship behaviors.
Value relevance of earnings and book value of equity in profit versus loss reporting firms: significance of intangible intensity
Authors: Kumari Pooja , Mishra Chandra Sekhar 
Published: April 2023

Purpose
This study aims to investigate how the intangible intensive nature of firms affects the value relevance of earnings and the book value of equity between profit- and loss-reporting firms. The study also examines how firms’ intangible intensity affects the value relevance of R&D outlays between profit- and loss-reporting firms.

Design/methodology/approach
An empirical analysis based on Ohlson’s (1995) framework is used. A total of 54,421 firm-year observations of Indian listed firms from financial years 1992–2016 constitute the study sample.

Findings
The findings suggest that the difference in the value relevance of earnings and the book value of equity between profit- and loss-reporting firms is more significant in non-intangible intensive firms than in intangible firms. Specifically, earnings are more value relevant in profit-reporting and non-intangible intensive firms, whereas book value of equity is more value relevant in loss-reporting and intangible intensive firms. The results also suggest that the difference in the incremental value relevance of R&D information between profit- and loss-making firms is higher in intangible intensive firms than in non-intangible intensive firms.

Practical implications
The findings of this study can help managers, standard-setters and investors make effective decisions.

Originality/value
This study offers insights into the impact of intangible intensity on the value relevance of aggregated and disaggregated accounting information between profit- and loss-making firms in institutional settings where capitalization of R&D expenditures is allowed.
Why not reprocessed: identifying factors limiting the uptake of reprocessed structural timber
Authors: Tennakoon Gihan Anuradha , Rameezdeen Raufdeen , Chileshe Nicholas 
Published: April 2023

PurposeTimber waste from construction is downcycled into non-structural products, incinerated for energy generation or disposed of in landfills. Existing literature highlights that the use of reprocessed timber for structural purposes is limited. Therefore, this study aims to focus on identifying factors limiting reprocessed structural timber (RST) uptake amongst construction professionals in Australia.Design/methodology/approachCurrent literature shows that the use of reprocessed materials (RMs) depends on user-specific personal factors and broader contextual factors. Therefore, data collection and analysis were based on the attitude-behaviour-context (ABC) theory, which affirms this relationship between personal and contextual factors in determining pro-environmental behaviours (PEBs). A qualitative research approach was adopted, considering limitations with industry expertise and the need for developing an in-depth understanding of limiting factors. Twenty semi-structured interviews were conducted amongst construction professionals experienced in using reprocessed materials, while the thematic analysis technique was used to analyse interview findings.FindingsPersonal factors that limit the uptake of RST include negative cost and quality perceptions, risk appetite, the tendency to maintain the status-quo, limited decision-making capability and lack of skills and expertise, while contextual factors include higher prices, poor and uncertain quality, limitations with information availability, under-developed supply and drawbacks in the regulatory environment.Originality/valueThe current study is amongst the first to explore the uptake of reprocessed timber for structural uses in Australia. The findings can be utilised to create a stronger demand for RST by directly addressing personal and contextual factors that constrain construction professionals from using RST.
Implicit integration of an anisotropic egg-shaped elastoplastic model for saturated soft clay
Authors: Ju Luying , Yan Zihai , Wu Mingming , Zhang Gangping , Yan Jiajia , Yu Tianci , Ding Pan , Xu Riqing 
Published: April 2023

PurposeThe purpose of this paper is to suggest an implicit integration method for updating the constitutive relationships in the newly proposed anisotropic egg-shaped elastoplastic (AESE) model and to apply it in ABAQUS.Design/methodology/approachThe implicit integration algorithm based on the Newton–Raphson method and the closest point projection scheme containing an elastic predictor and plastic corrector are implemented in the AESE model. Then, the integration code for this model is incorporated into the commercial finite element software ABAQUS through the user material subroutine (UMAT) interface to simulate undrained monotonic triaxial tests for various saturated soft clays under different consolidation conditions.FindingsThe comparison between the simulated results from ABAQUS and the experimental results demonstrates the satisfactory performance of this implicit integration algorithm in terms of effectiveness and robustness and the ability of the proposed model to predict the characteristics of soft clay.Research limitations/implicationsThe rotational hardening rule in the AESE model together with the implicit integration algorithm cannot be considered.Originality/valueThe singularity problem existing in most elastoplastic models is eliminated by the closed, smooth and flexible anisotropic egg-shaped yield surface form in the AESE model. In addition, this notion leads to an efficient implicit integration algorithm for updating the highly nonlinear constitutive equations for unsaturated soft clay.
Business families do it differently! Navigating cycles and waves of family firm internationalization
Authors: Calabrò Andrea , Mayrhofer Ulrike , Valentino Alfredo 
Published: April 2023

PurposeThis paper aims at extending the debate on family firm internationalization by identifying cycles and waves of their internationalization processes with a specific focus on de-internationalization and re-internationalization.Design/methodology/approachBuilding on the Uppsala model and the resource-based view, this study analyzes the cycles and waves of internationalization of 26 German family firms in the Chinese market. Semi-structured interviews with top managers of the selected case firms were conducted, and secondary sources were used to triangulate the collected data.FindingsThe findings highlight the heterogeneity of family firm internationalization processes. Indeed, some family firms follow the sequential approach of the Uppsala model, while others choose to de-internationalize and then re-internationalize their activities. Their cycles and waves of internationalization can be explained by internal and external triggers.Originality/valueThis article contributes to the family firm internationalization literature by investigating how family firm characteristics and environmental factors shape internationalization, de-internationalization and re-internationalization paths. The novel findings enrich theoretical assumptions on family firm internationalization and highlight their varying internationalization processes, which can be explained by firm-specific characteristics, notably their unique family resources and socioemotional wealth, and contextual factors.
A privacy-preserving federated learning architecture implementing data ownership and portability on edge end-points
Authors: Mpofu Patience , Kembo Solomon Hopewell , Chimbwanda Marlvern , Jacques Saulo , Chitiyo Nevil , Zvarevashe Kudakwashe 
Published: April 2023

PurposeIn response to food supply constraints resulting from coronavirus disease 2019 (COVID-19) restrictions, in the year 2020, the project developed automated household Aquaponics units to guarantee food self-sufficiency. However, the automated aquaponics solution did not fully comply with data privacy and portability best practices to protect the data of household owners. The purpose of this study is to develop a data privacy and portability layer on top of the previously developed automated Aquaponics units.Design/methodology/approachDesign Science Research (DSR) is the research method implemented in this study.FindingsGeneral Data Protection and Privacy Regulations (GDPR)-inspired principles empowering data subjects including data minimisation, purpose limitation, storage limitation as well as integrity and confidentiality can be implemented in a federated learning (FL) architecture using Pinecone Matrix home servers and edge devices.Research limitations/implicationsThe literature reviewed for this study demonstrates that the GDPR right to data portability can have a positive impact on data protection by giving individuals more control over their own data. This is achieved by allowing data subjects to obtain their personal information from a data controller in a format that makes it simple to reuse it in another context and to transmit this information freely to any other data controller of their choice. Data portability is not strictly governed or enforced by data protection laws in the developing world, such as Zimbabwe's Data Protection Act of 2021.Practical implicationsPrivacy requirements can be implemented in end-point technology such as smartphones, microcontrollers and single board computer clusters enabling data subjects to be incentivised whilst unlocking the value of their own data in the process fostering competition among data controllers and processors.Originality/valueThe use of end-to-end encryption with Matrix Pinecone on edge endpoints and fog servers, as well as the practical implementation of data portability, are currently not adequately covered in the literature. The study acts as a springboard for a future conversation on the topic.
Study of jet tabs in 2D convergent–divergent nozzle for thrust vectoring in aerial vehicles
Authors: Jyothy V.M. , John Wessley G. Jims 
Published: April 2023

PurposeIn this study, 2D density-based SST K-turbulence model with compressibility effect is used to observe the flow separation and shock wave interactions of the flow. The wall static pressure and Mach number differences are also evaluated. This study aims to discuss the aforementioned objectivesDesign/methodology/approachThis study outlines the evaluation of the performance of a 2D convergent–divergent nozzle with various triangular jet tab configurations that can be used for effective thrust vectoring of aerial vehicles.FindingsFrom the study, it is seen that the shadow effect induced by the tab with a height of 30% produces higher oblique wave deflection and higher thrust deflection at the exit nozzle. The numerical calculation concluded that thrust vector efficiency of 30% jet tab is, 0.46%. In the case of 10% jet tab height the thrust vector efficiency is higher, i.e. 1.647%.Research limitations/implications2D study.Practical implicationsThe optimization will open up a new focus in TVC that can be implemented for effective attitude control in aircrafts.Social implicationsUsed in future aircrafts.Originality/valueThe influence of shadowing ratio with different tab heights at different Mach numbers has not been reported in the previous studies. Few of the studies on jet tab are focused on the acoustic studies and not pertaining to the aerodynamic aspects. The multi jet configuration, the combination of location, shapes and other parametric analysis have not been covered in the previous studied.
Adoption of online crowdsourced logistics during the pandemic: a consumer-based approach
Authors: Koh Le Yi , Peh Ying Sien , Wang Xueqin , Yuen Kum Fai 
Published: April 2023

PurposeThe COVID-19 pandemic has resulted in a brand-new phenomenon in customer consumption patterns. This resulted from heightened health awareness brought on by the COVID-19 epidemic. There is a dearth of appropriate health psychology perspectives in the existing study examining the effect of COVID-19 on consumers’ use of crowdsourced logistics (CL) platforms. In order to provide unique and thorough insights into how consumer health concerns can affect consumers’ subjective views and their decisions to use CL, this study combines the health belief model and the technology acceptance model.Design/methodology/approachFive hundred valid responses from an online survey that was created and administered in Singapore were analysed using structural equation modelling.FindingsThe findings show that all of the suggested constructs have a favourable influence on consumers’ intentions to use CL. The suggested model also demonstrates high explanatory power, with perceived usefulness serving as the primary driver, followed by perceived ease of use and self-efficacy.Originality/valueThe study advances previous academic research on CL and offers guidance to CL companies and lawmakers for promoting sustainable and secured last-mile delivery.
The role of vicarious learning strategies in shaping consumers' uncertainty: the case of live-streaming shopping
Authors: Men Jinqi , Zheng Xiabing , Davison Robert M. 
Published: April 2023

PurposeThis article seeks to understand how live-streaming technology (i.e. interactivity and effective use of live-streaming shopping’s information presentation tool) impacts consumers’ credibility perception regarding live streamers.Design/methodology/approachThe authors empirically examined their hypotheses with data (n = 405) collected from a survey of consumers who engage in live-streaming shopping.FindingsThe results demonstrate that vicarious learning strategies (both coactive and independent) can shape consumers’ benefit perceptions (i.e. virtual presence and psychological proximity), and further have a positive effect on consumers’ personal value (i.e. perceived live streamer credibility). Furthermore, the consumers’ perception of the live streamers’ credibility positively affects their purchase intention and ultimately influences their purchase behavior.Originality/valueBuilding on the vicarious learning theory and means-end chain (MEC) model, this study investigates the mechanism of the IT features of live-streaming shopping in reducing consumers’ uncertainty about live streamers. This study reveals the value of vicarious learning experiences in reducing consumers’ uncertainty and further enhancing their purchase behavior.
Factors influencing the intensity of market participation of coffee processors in Uganda
Authors: Phiona Natuha , Ambrose Aheisibwe Rwaheru 
Published: April 2023

PurposeThis paper aims to examine the level of market participation of coffee processors and the factors that influence their intensity of market participation for processed coffee in Uganda.Design/methodology/approachThis paper studies dry processing of coffee using survey data from purposively selected sample of 120 coffee processors in Uganda. The study utilizes descriptive analysis and Tobit regression approach.FindingsThis paper finds the level of participation of coffee processors in the sale of processed coffee at 77.8 percent in Uganda. The findings demonstrate that the intensity of market participation of coffee processors is positively and significantly influenced by Kiboko sales revenue, location, experience of the processor, number of visits by Uganda Coffee Development Authority and processor mill capacity. However, credit access and non-farm income negatively and significantly deterred their intensity of market participation.Research limitations/implicationsThe paper shows that there is more potential for coffee processors to increase their intensity of market participation given their current capacity for coffee processing. Therefore, insights on production efficiency and market orientation in coffee value chains would be an issue for future studies.Social implicationsThe study has a direct implication on the economy through supportive institutions and increased investment in the value addition of coffee to meet the increasing regional and global demand for processed coffee.Originality/valueThis paper bridges the gap in literature on commercialization of coffee processing, allows to determine processors' level of market participation and with application of Tobit regression approach to quantify the effects of the factors that influence the intensity of market participation in coffee value chains in Uganda.
Vision-guided robotic automation of vat polymerization additive manufacturing production: design, calibration and verification
Authors: Yang Wenzhen , Crone Johan K. , Lønkjær Claus R. , Ribo Macarena Mendez , Shan Shuo , Frumosu Flavia Dalia , Papageorgiou Dimitrios , Liu Yu , Nalpantidis Lazaros , Zhang Yang 
Published: April 2023

PurposeThis study aims to present a vision-guided robotic system design for application in vat photopolymerization additive manufacturing (AM), enabling vat photopolymerization AM hybrid with injection molding process.Design/methodology/approachIn the system, a robot equipped with a camera and a custom-made gripper as well as driven by a visual servoing (VS) controller is expected to perceive objective, handle variation, connect multi-process steps in soft tooling process and realize automation of vat photopolymerization AM. Meanwhile, the vat photopolymerization AM printer is customized in both hardware and software to interact with the robotic system.FindingsBy ArUco marker-based vision-guided robotic system, the printing platform can be manipulated in arbitrary initial position quickly and robustly, which constitutes the first step in exploring automation of vat photopolymerization AM hybrid with soft tooling process.Originality/valueThe vision-guided robotic system monitors and controls vat photopolymerization AM process, which has potential for vat photopolymerization AM hybrid with other mass production methods, for instance, injection molding.