bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug interactions in patients with alcohol use disorder: results from a real-world study on an addiction-specific ward
Authors: Schröder Sebastian , Massarou Christina , Pfister Tabea , Bleich Stefan , Proskynitopoulos Phileas Johannes , Heck Johannes , Schulze Westhoff Martin , Glahn Alexander 
Published: January 2025

Background: The majority of patients with alcohol use disorder (AUD) regularly take medication. Alcohol interacts negatively with many commonly prescribed drugs. However, little is known about the characteristics and frequency of potential alcohol–medication and drug–drug interactions in patients with AUD. Objectives: This study aimed to determine the prevalence and characteristics of drug interactions in patients with AUD during withdrawal therapy on an addiction-specific ward. Design: Retrospective cohort study. Methods: Medication charts were analyzed and screened for potential alcohol–medication and drug–drug interactions. For the screening of potential alcohol–medication interactions, the drugs.com classification was utilized and potential drug–drug interactions were identified using the mediQ electronic interaction program. Results: In our study, almost two-thirds (66.3%; 1089/1643) of all patient cases were prescribed at least one drug that could potentially interact with alcohol. Four percent of all alcohol–medication interactions were classified as severe, 91.8% as moderate, and 4.3% as mild. Drug classes commonly involved in serious interactions with alcohol were analgesics and drugs used in diabetes. A total of 811 potential drug–drug interactions were identified, of which 3.3% were classified as severe and 96.5% as moderate. Psychoanaleptics (ATC N06) and psycholeptics (ATC N05) were most frequently associated with moderate to severe interactions. Conclusion: Potential alcohol–medication and drug–drug interactions are common in hospitalized patients with AUD. Improvements in the quality of prescribing should focus on the use of psychotropic drugs.
Immunohistochemical expression of parathyroid hormone-related protein and ezrin in invasive breast carcinoma of no special type: a retrospective analysis
Authors: Shalaby Menna Allah Gamil Ali , Dawoud Marwa Mohammed , Gadallah Marwa Salah , Abdou Asmaa Gaber 
Published: January 2025

Abstract

Background
Globally, breast cancer ranks among the most common malignancies and has a high mortality rate. Invasive breast carcinoma of no special type (IBC-NST) presents a heterogeneous group with variable prognosis. Identifying reliable biomarkers is crucial for improving treatment strategies and predicting outcomes. This study investigates the immunohistochemical expression of parathyroid hormone-related protein (PTHrP) and ezrin in IBC-NST and their correlation with clinicopathological features and overall survival.

Methods
This retrospective study analyzed 160 paraffin-embedded tissue samples, including 123 IBC-NST and 37 normal breast tissues, collected from patients treated at Menoufia University Hospital during the period from January 2018 to January 2022. Immunohistochemical staining for PTHrP and ezrin was performed, and expression levels were quantified using the H score.

Results
PTHrP expression was significantly higher in IBC-NST than in adjacent DCIS and normal tissues (p < 0.001). High PTHrP percent of expression was associated with metastasis (p = 0.009), bone metastasis (p = 0.012), and lymphovascular invasion (p = 0.037). Ezrin expression was also significantly elevated in IBC-NST, with higher H score values correlating with high tumor grade (p = 0.002), high N stage (p = 0.045), advanced AJCC stage grouping (p = 0.0043) and metastasis (p = 0.001). A significant positive correlation was observed between PTHrP and ezrin expression (rs = 0.341, p < 0.001). Kaplan-Meier analysis showed that high ezrin expression, in terms of intensity (p = 0.007) and H score (p = 0.002), was linked to poorer survival.

Conclusion
The study highlights the significant roles of PTHrP and ezrin in breast cancer progression. Elevated levels of these proteins are associated with more aggressive disease, suggesting their capability as prognostic indicators and treatment targets in breast cancer. Additional studies are required to investigate their interaction and collective influence on breast cancer metastasis and treatment.
Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications
Authors: Mwale Pharaoh Fellow , Hsieh Cheng-Ta , Yen Ting-Lin , Jan Jing-Shiun , Taliyan Rajeev , Yang Chih-Hao , Yang Wen-Bin 
Published: January 2025

Abstract
Chitinase-3-like-1 (CHI3L1) is an evolutionarily conserved protein involved in key biological processes, including tissue remodeling, angiogenesis, and neuroinflammation. It has emerged as a significant player in various neurodegenerative diseases and brain disorders. Elevated CHI3L1 levels have been observed in neurological conditions such as traumatic brain injury (TBI), Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), Creutzfeldt-Jakob disease (CJD), multiple sclerosis (MS), Neuromyelitis optica (NMO), HIV-associated dementia (HAD), Cerebral ischemic stroke (CIS), and brain tumors. This review explores the role of CHI3L1 in the pathogenesis of these disorders, with a focus on its contributions to neuroinflammation, immune cell infiltration, and neuronal degeneration. As a key regulator of neuroinflammation, CHI3L1 modulates microglia and astrocyte activity, driving the release of proinflammatory cytokines that exacerbate disease progression. In addition to its role in disease pathology, CHI3L1 has emerged as a promising biomarker for the diagnosis and monitoring of brain disorders. Elevated cerebrospinal fluid (CSF) levels of CHI3L1 have been linked to disease severity and cognitive decline, particularly in AD and MS, highlighting its potential for clinical diagnostics. Furthermore, therapeutic strategies targeting CHI3L1, such as small-molecule inhibitors and neutralizing antibodies, have shown promise in preclinical studies, demonstrating reduced neuroinflammation, amyloid plaque accumulation, and improved neuronal survival. Despite its therapeutic potential, challenges remain in developing selective and safe CHI3L1-targeted therapies, particularly in ensuring effective delivery across the blood–brain barrier and mitigating off-target effects. This review addresses the complexities of targeting CHI3L1, highlights its potential in precision medicine, and outlines future research directions aimed at unlocking its full therapeutic potential in treating neurodegenerative diseases and brain pathologies.
Discovering non-associated pressure-sensitive plasticity models with EUCLID
Authors: Xu Haotian , Flaschel Moritz , De Lorenzis Laura 
Published: January 2025

Abstract
We extend (EUCLID Efficient Unsupervised Constitutive Law Identification and Discovery)—a data-driven framework for automated material model discovery—to pressure-sensitive plasticity models, encompassing arbitrarily shaped yield surfaces with convexity constraints and non-associated flow rules. The method only requires full-field displacement and boundary force data from one single experiment and delivers constitutive laws as interpretable mathematical expressions. We construct a material model library for pressure-sensitive plasticity models with non-associated flow rules in four steps: (1) a Fourier series describes an arbitrary yield surface shape in the deviatoric stress plane; (2) a pressure-sensitive term in the yield function defines the shape of the shear failure surface and determines plastic deformation under tension; (3) a compression cap term determines plastic deformation under compression; (4) a non-associated flow rule may be adopted to avoid the excessive dilatancy induced by plastic deformations. In contrast to traditional parameter identification methods, EUCLID is equipped with a sparsity promoting regularization to restrain the number of model parameters (and thus modeling features) to the minimum needed to accurately interpret the data, thus achieving a compromise between model simplicity and accuracy. The convexity of the learned yield surface is guaranteed by a set of constraints in the inverse optimization problem. We demonstrate the proposed approach in multiple numerical experiments with noisy data, and show the ability of EUCLID to accurately select a suitable material model from the starting library.
Maraviroc/cisplatin combination inhibits gastric cancer tumoroid growth and improves mice survival
Authors: Mora-Lagos Bárbara , Reyes María Elena , Lobos-Gonzalez Lorena , del Campo Matías , Buchegger Kurt , Zanella Louise , Riquelme Ismael , Ili Carmen Gloria , Brebi Priscilla 
Published: January 2025

Abstract

Background
Gastric cancer (GC) is a significant cancer-related cause of death worldwide. GC’s most used chemotherapeutic regimen is based on platinum drugs such as cisplatin (CDDP). However, CDDP chemoresistance reduces the survival rate of advanced GC. The immune C-C chemokine receptor type 5 (CCR5) have been proposed as a pivotal factor in cancer progression since its blockade has been linked with antineoplastic effects on tumor cell proliferation; nevertheless, its role in the chemoresistance of GC has not been elucidated. This study aimed to determine the effects induced by the CCR5 using Maraviroc (MVC), a highly selective CCR5 antagonist, on CDDP-resistant AGS cells (AGS R-CDDP), tumoroids (3D tumor spheroids), and animal models.

Results
The combined CDDP and MVC treatment reduced cell viability and inhibited tumoroid formation in AGS R-CDDP cells. The effects of the MVC/CDDP combination on apoptosis and cell cycle progression were correlated with the increase in CDDP (dose-dependent). The mRNA levels of C-C Motif Chemokine Ligand 5 (CCL5), the main ligand for CCR5, decreased significantly in cells treated with the MVC/CDDP combination. MVC in the MVC/CDDP combination improved the survival rate and biochemical parameters of CDDP-treated mice by reducing the side effects of CDDP alone.

Conclusions
This finding suggests that MVC/CDDP combination could be a potential complementary therapy for GC.
Sustaining innovations in educational technology
Authors: Cox Glenda 
Published: January 2025

Educational technology is increasingly being used to enhance teaching and learning activities in higher education. One of the persistent challenges has been how to encourage, support and sustain these innovative practices which rest largely on the individual lecturer. At the University of Cape Town, the Centre for Educational Technology (CET) has endeavoured to encourage and support pedagogic innovation through various mechanisms including the allocation of teaching with technology innovation grants. Findings of a recent survey of these grant recipients reveal how lecturers are sustaining these innovations over time. Using Archer's (2003) social realist approach this study is showing that lecturers' ultimate concerns, expressed in their reasons for changing the way they teach, have resulted in “projects” that have been successful and which have led to established practices. These projects have been sustained because they were created as a result of a specific pedagogical need and have been embedded in the courses for which they were created. Lecturers' practices have been supported by working in teams, sharing their teaching practice with others and receiving both financial and technical support from CET. This suggests that the key to maintaining innovative use of educational technology for teaching and learning in higher education should be centred on the notion of pedagogical sustainability.

Keywords: pedagogical sustainability, innovation in teaching with technology, active agents, grants, Archer
Teachers, technology and design
Authors: Goodyear Peter , Markauskaite Lina , Agostinho Shirley , Lockyer Lori , Dalziel James , Cameron Leanne 
Published: January 2025

Deciding how best to combine good learning tasks and appropriately supportive technology is becoming increasingly complicated. Teachers in higher education are struggling with rising expectations about graduate capabilities, a diversifying intake, increasing pressure on time and a dizzying proliferation of technology options. One response we are seeing is a strengthening interest in taking a more design-based approach to tackling what many would see as ‘wicked problems’ (Luckin, 2010; Hoadley, 2010; Goodyear & Retalis, 2010). This symposium provides an opportunity to discuss some of the latest insights from research on teachers’ experiences with the tools and methods of educational design (aka ‘design for learning’).

Keywords: learning tasks, educational design, LAMS
The effect of a combined long‐duration static stretching and resistance training regimen on a competitive bodybuilder: A case study
Authors: Homer Kai A. , Helms Eric R. , Spence Alyssa‐Joy 
Published: January 2025

AbstractBoth resistance training (RT) and long‐duration, high‐intensity stretching induce muscular adaptations; however, it is unknown whether the modalities are complementary or redundant, particularly in well‐trained individuals. A case‐study was conducted on a competitive bodybuilder implementing long‐duration, high‐intensity stretching of the plantar flexors (60 min 6x/week for 12 weeks) in conjunction with their habitual RT. Ultrasound muscle architecture (muscle thickness [MT], fascicle length [FL], and pennation angle [PA]) measurements were collected at multiple sites at four weekly baseline sessions, six (mid) and 12 (post1) weeks following the commencement of the intervention, and a week after the intervention (post2) while isometric strength and range of motion (RoM) were obtained once at baseline, mid, post1, and post2. 2SD band plots were constructed to determine meaningful changes in MT, FL, and PA from the four baseline measures while percentage and absolute change across each timepoint were calculated for all variables. From baseline to post 1, RoM, strength, and MT increased 25.9%, 11.4%, and 7.4%–23.4%, respectively, while four MT and two PA sites exceeded the threshold for meaningful change. The combined stretching and RT protocols resulted in flexibility, strength, and MT adaptations; however, findings should be generalized with caution given the case‐study nature of our investigation.
PIBID E CAPOEIRA: MOVIMENTO, DANÇA E EDUCAÇÃO
Authors: De Sousa Borges Kallyne , Bernardo Lima Layanna Giordana 
Published: January 2025

O presente relato tem como objetivo apresentar a experiência vivenciada no Programa Institucional de Bolsa de Iniciação à Docência – PIBID, que promoveu atividades pedagógicas de capoeira com a turma do quinto ano, em uma Escola Municipal do Estado do Tocantins no ano de 2023. Tendo como base o relatório PIBID e pesquisa bibliográfica, foi elaborado o presente texto. A atividade pedagógica analisada foram os momentos da oficina: “Capoeira na escola”, com objetivo de desenvolver a musicalidade, coletividade, movimento e a história da capoeira articulando com as questões étnico-raciais. Desse modo, promover as atividades envolvendo a capoeira nos espaços de aprendizagens de valorização da cultura e história da formação social afro-brasileira, contribuiu para a aprendizagem e enaltecimento da cultura, assim como para a prevenção e o combate ao racismo nas salas de aulas.
SEISMIC EFFECTS OF FLOODS OBSERVED ON THE KYNGARGA RIVER (Tunka Valley, Eastern Sayan)
Authors: Dobrynina A.A. , San’kov V.A. , Korol S.A. , Kichigina N.V. , Rybchenko A.A. 
Published: January 2025

Variations in ambient seismic noise generated by the Kyngarga river (Tunka Valley) in the calm state and during significantly rising water levels were analyzed, based on the Arshan short-period seismic station data, observations of water level fluctuations at the Kyngarga Rv. hydrological station, and the amount of rainfall measured with precipitation gauge at Peak Lyubvi mountain (Mt). The methods used in the work include the correlation, spectral, spectral-temporal and polarization analyses. Ambient noise vibrations recorded at the Arshan seismic station show instable over time and show significant seasonal variations. During warm periods, the ice cover melting increases the water level in the Kyngarga River, thus causing amplification of seismic vibrations in the frequency range from 2 to 20 Hz. Occurrence of heavy rainfalls and subsequent significant rise in the Kyngarga river water levels (floods) lead to changes in the amplitude-to-frequency response characteristics of ambient seismic noise. This translates into amplification of seismic vibrations in the frequency range from 4 to 20 Hz, with maximum seismic radiation (radiative transfer of seismic waves) in the 6–10 Hz frequency range. For different floods, the amplification varies significantly and depends on the magnitude of the water level rise. Variation of amplitude-frequency characteristics of the ambient seismic noise in summer relative to winter, as well as during floods, is driven by increased water flow turbulence with affiliated increase in water flow velocity and discharge, and sediment dynamics. Diagrams showing particle motion in the medium in a calm state and during floods do not show any dominant orientation of oscillations, which is associated with the length of the source of vibrations whose extent (in this case) is equal to the entire river channel.
Sosiaaliluokka ja perheroolit naisten terveyden tutkimuksessa
Authors: Arber Sara 
Published: January 2025

Sosiaaliluokka on hallinnut brittiläistä terveydentilan erojen tutkimusta. Naisten terveydentilan tarkastelu on tullut mukaan vasta myöhään. Yhdysvaltalaista perinnettä on hallinnut roolien tarkastelu. Naisten terveyttä on tutkittu etupäässä heidän avio-, perhe- ja työrooleissaan. Tutkimus on päätynyt ristiriitaisiin johtopäätöksiin.
Tässä artikkelissa analysoidaan brittiläistä General Household Survey'ta (GHS) ja pyritään osoittamaan, kuinka molempia tutkimusperinteitä on muotoiltava uudestaan ja yhdistettävä. Vuosien 1985 ja 1986 GHS:n aineistoihin kuuluu yli 25 000 miestä ja naista. Aineelliset elinolot määräävät, miten perheroolit liittyvät naisten terveydentilaan, mutta ammattiin perustuva sosiaaliluokka ei yksin kata aineellisia elinoloja. Rakenteellista huono-osaisuutta osoittavat palkkatyöhön osallistuminen, kulutuksen erot ja asunnon omistussuhde.
Ikävakioidut haittaavaa pitkäaikaissairastavuutta koskevat tiedot sekä logistisen regressioanalyysin tulokset osoittavat, että sosiaaliluokka ja palkkatyöhön osallistuminen ovat yhteydessä naisten ja miesten terveydentilaan. Naisilla perheroolit ovat tärkeitä. Naisten keskuudessa lapsettomien, eronneiden ja leskien, varsinkin palkkatyön ulkopuolella olevien ja kunnallisissa asunnoissa asuvien terveydentila on erityisen huono.
Wilhelm Joachim Sucksdorff (1851-1934)
Authors: Hirvonen Leo 
Published: January 2025

Wilhelm Joachim Sucksdorff (1851–1954), FK 1875, LK 1878, LL 1883, LKT 1886, hygienian dosentti 1887, hoiti ensimmäisenä vakinaisena viranhaltijana vuonna 1890 perustettua Helsingin yliopiston hygienian ylimääräistä professorin virkaa 1894–1895 ja toimi sen jälkeen Helsingin ensimmäisenä kaupunkilääkärinä vuoteen 1917. Sucksdorff perehtyi huolellisesti kiihkeässä kehitysvaiheessa olleeseen bakteriologiaan Leipzigin hygieenisessä laboratoriossa Fr. Hofmanin johdolla. Väitöstutkimuksessaan hän tutki bakteriologisin keinoin veden laadun arviointia ja pyykin desinfioitumista pesussa. Sucksdorff harrasti monipuolista terveys- ja raittiuskasvatusta sekä osallistui niihin liittyvään ja uskonnolliseen järjestötoimintaan vuosikymmenien ajan. Hän julkaisi Tidskrift för Hälsovård -nimistä aikakauslehteä vuosina 1891–1918.
Enhancing Students’ Critical Thinking Skills through Problem-Based Learning and Diorama Media: A Study at SD 3 Jurang
Authors: Anggraini Ririn 
Published: January 2025

This research is motivated by monotonous learning using conventional models such as lectures and limited media usage, which can result in a lack of students' critical thinking skills. The objective of this research is to enhance students' critical thinking skills in IPAS material by using the Problem Based Learning model and diorama media. The Classroom Action Research method consists of 2 cycles with 2 meetings. The research subjects in the fifth grade of SDN 3 Jurang for the 2023/2024 academic year consist of 17 students, with 8 male students and 9 female students. The data analysis techniques used are quantitative and qualitative. Qualitative data were obtained through performance observation sheets, while quantitative data were obtained through evaluation tests. The results of the study showed significant achievements, with the assessment of students' critical thinking skills using the Problem Based Learning model and diorama media obtaining a score of 61.6 with a completion percentage of 35.3% in Cycle I, increasing to 80.9 with a completion percentage of 82.4% in Cycle II which means it is included in the Very Critical category. This study should allow teachers to apply the Problem Based Learning model and diorama media more interestingly through practice and group discussions, through this model students can improve critical thinking patterns in science learning.
Politik Islam Inklusif dalam Perspektif Rached Ghannauchi
Authors: Khudri Nur Saadah , Ritonga Mahyudin , SA Saifullah 
Published: January 2025

Penelitian ini bertujuan untuk menganalisa lebih dalam tentang dinamika pemikiran politik Islam di Tunisia yang di pelopori oleh Rached Ghannauchi sebagai pimpinan partai Ennahda, dimana perspektif politik yang ada saat itu lebih bersifat otoriter, sehingga membuat Rached Ghannauchi menawarkan sebuah inovasi baru tentang politik Islam yang lebih inklusif dan akomodatif, yang menjunjung tinggi demokrasi tanpa meninggalkan prinsip-prinsip keislaman dalam perpolitikan Islam. Penelitian ini menggunakan metode kualitatif yang berbentuk jenis penelitian keperpustakaan dengan pengumpulan data dari berbagai sumber buku, jurnal dan artikel ilmiah yang mempunyai relevansi dengan topik penelitian. Selanjutnya data-data temuan dianalisa secara deskriptif yang mencakup analisis literatur tentang pemikiran politik Islam inklusif menurut Rached Ghannauchi sehingga dapat membantu pembaca untuk memahami bahwa politik Islam inklusif itu terintegrasi dengan prinsip-prinsip demokrasi modern. Hasil dari penelitian ini menjelaskan bahwa Islam dan modernisasi bukan suatu yang bertentangan melainkan dapat saling melengkapi untuk menciptakan politik yang inklusif. Ghannauchi menekatkan ijtihad dan juga menyoroti tentang bagaimana menghormati dan menyikapi dengan benar terhadap pluralitas yang terjadi pada masyarakat modern, untuk mencegah ekstremisme yang anti terhadap non islam, supaya terjadi stabilitas politik dan hamonisasi di masyarakat melalui politik Islam yang lebih akomodatif dan inklusif.Kata Kunci: Inklusif, Politik Islam, Rached Ghannauchi
PEMBERDAYAAN PULAU-PULAU KECIL TERLUAR SEBAGAI GARDA TERDEPAN WILAYAH NEGARA KESATUAN REPUBLIK INDONESIA
Authors: Herawati Augustin Rina , Suprapto, S.E. Gatot , Wahono Jamroji D. 
Published: January 2025

AbstractÂ The Republic of Indonesia with a coastline length of 81,000 km and with 17,499 large and small islands, both inhabited and uninhabited, makes Indonesia the largest archipelagic country in the world. Empowerment of the outer small islands is very much needed so that these areas remain monitored, and the people of these regions realize and even feel that their existence as the outermost and remote small island communities is the Leading Guard of the Unitary State of the Republic of Indonesia, loves their country and has high state defense awareness. The change in the paradigm of developing the border region to become the "Front Guard" will be able to direct various policies both regulations and investments to the border regions and outer small islands that actually have great potential as the Leading Guard of the Unitary State of the Republic of Indonesia.Keywords:Â Island States, development of border areas