bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study
Authors: Ormesher Laura , Vause Sarah , Higson Suzanne , Roberts Anna , Clarke Bernard , Curtis Stephanie , Ordonez Victoria , Ansari Faiza , Everett Thomas R. , Hordern Claire , Mackillop Lucy , Stern Victoria , Bonnett Tessa , Reid Alice , Wallace Suzanne , Oyekan Ebruba , Douglas Hannah , Cauldwell Matthew , Reddy Maya , Palmer Kirsten , Simpson Maggie , Brennand Janet , Minns Laura , Freeman Leisa , Murray Sarah , Mary Nirmala , Castleman James , Morris Katie R. , Haslett Elizabeth , Cassidy Christopher , Johnstone Edward D. , Myers Jenny E. 
Published: January 2023

AbstractPre-eclampsia is associated with postnatal cardiac dysfunction; however, the nature of this relationship remains uncertain. This multicentre retrospective cohort study aimed to determine the prevalence of pre-eclampsia in women with pre-existing cardiac dysfunction (left ventricular ejection fraction < 55%) and explore the relationship between pregnancy outcome and pre-pregnancy cardiac phenotype. In this cohort of 282 pregnancies, pre-eclampsia prevalence was not significantly increased (4.6% [95% C.I 2.2–7.0%] vs. population prevalence of 4.6% [95% C.I. 2.7–8.2], p = 0.99); 12/13 women had concurrent obstetric/medical risk factors for pre-eclampsia. The prevalence of preterm pre-eclampsia (< 37 weeks) and fetal growth restriction (FGR) was increased (1.8% vs. 0.7%, p = 0.03; 15.2% vs. 5.5%, p < 0.001, respectively). Neither systolic nor diastolic function correlated with pregnancy outcome. Antenatal ß blockers (n = 116) were associated with lower birthweight Z score (adjusted difference − 0.31 [95% C.I. − 0.61 to − 0.01], p = 0.04). To conclude, this study demonstrated a modest increase in preterm pre-eclampsia and significant increase in FGR in women with pre-existing cardiac dysfunction. Our results do not necessarily support a causal relationship between cardiac dysfunction and pre-eclampsia, especially given the population’s background risk status. The mechanism underpinning the relationship between cardiac dysfunction and FGR merits further research but could be influenced by concomitant ß blocker use.
Enhancing grasshopper optimization algorithm (GOA) with levy flight for engineering applications
Authors: Wu Lei , Wu Jiawei , Wang Tengbin 
Published: January 2023

AbstractThe grasshopper optimization algorithm (GOA) is a meta-heuristic algorithm proposed in 2017 mimics the biological behavior of grasshopper swarms seeking food sources in nature for solving optimization problems. Nonetheless, some shortcomings exist in the origin GOA, and GOA global search ability is more or less insufficient and precision also needs to be further improved. Although there are many different GOA variants in the literature, the problem of inefficient and rough precision has still emerged in GOA variants. Aiming at these deficiencies, this paper develops an improved version of GOA with Levy Flight mechanism called LFGOA to alleviate the shortcomings of the origin GOA. The LFGOA algorithm achieved a more suitable balance between exploitation and exploration during searching for the most promising region. The performance of LFGOA is tested using 23 mathematical benchmark functions in comparison with the eight well-known meta-heuristic algorithms and seven real-world engineering problems. The statistical analysis and experimental results show the efficiency of LFGOA. According to obtained results, it is possible to say that the LFGOA algorithm can be a potential alternative in the solution of meta-heuristic optimization problems as it has high exploration and exploitation capabilities.
Study on adsorption of hexavalent chromium by composite material prepared from iron-based solid wastes
Authors: Qi Jiamin , Li Bin , Zhou Pengxiang , Su Xintai , Yang Di , Wu Jinxiong , Wang Zixuan , Liang Xiangjing 
Published: January 2023

AbstractA new adsorbent with chromium removal function was synthesized by carbon thermal method using iron-containing waste Fenton sludge and carbon-containing solid waste fly ash to treat high pH scoring wastewater generated from industrial processes. The results showed that the adsorbent used T = 273.15 K, pH = 10, t = 1200 min, C0 = 100 mg/L, had a removal rate of Cr(VI) of more than 80%, and the adsorption capacity could reach 393.79 mg/g. The characterization results show that the synthesized mesoporous nitrogen-doped composite material has a large specific surface area and mesoporous structure, and the surface of the material is rich in oxygen-containing functional groups and active sites. Compared with other studies, the adsorption capacity of the material is larger, which indicates that the removal effect of Cr(VI) in this study is better. The adsorption kinetic results show that the adsorption follows a pseudo second kinetic model, and the adsorption process is a chemisorption involving electron sharing or electron exchange. This experiment designed a simple method to synthesize mesoporous nitrogen-doped composites using industrial solid waste, with raw materials from cheap and easily available industrial solid waste, and solved the dual problems of heavy metals in wastewater and solid waste, providing a new idea for the resource utilization of Fenton sludge while not producing secondary pollution.
Characterization of metabolic reprogramming by metabolomics in the oncocytic thyroid cancer cell line XTC.UC1
Authors: Kurashige Tomomi , Shimamura Mika , Hamada Koichiro , Matsuse Michiko , Mitsutake Norisato , Nagayama Yuji 
Published: January 2023

AbstractOncocytic thyroid cancer is characterized by the aberrant accumulation of abnormal mitochondria in the cytoplasm and a defect in oxidative phosphorylation. We performed metabolomics analysis to compare metabolic reprogramming among the oncocytic and non-oncocytic thyroid cancer cell lines XTC.UC1 and TPC1, respectively, and a normal thyroid cell line Nthy-ori 3-1. We found that although XTC.UC1 cells exhibit higher glucose uptake than TPC1 cells, the glycolytic intermediates are not only utilized to generate end-products of glycolysis, but also diverted to branching pathways such as lipid metabolism and the serine synthesis pathway. Glutamine is preferentially used to produce glutathione to reduce oxidative stress in XTC.UC1 cells, rather than to generate α-ketoglutarate for anaplerotic flux into the TCA cycle. Thus, growth, survival and redox homeostasis of XTC.UC1 cells rely more on both glucose and glutamine than do TPC1 cells. Furthermore, XTC.UC1 cells contained higher amounts of intracellular amino acids which is due to higher expression of the amino acid transporter ASCT2 and enhanced autophagy, thus providing the building blocks for macromolecules and energy production. These metabolic alterations are required for oncocytic cancer cells to compensate their defective mitochondrial function and to alleviate excess oxidative stress.
Nutrient patterns in relation to metabolic health status in overweight and obese adolescents
Authors: Rouhani Parisa , Mirzaei Saeideh , Asadi Ali , Akhlaghi Masoumeh , Saneei Parvane 
Published: January 2023

AbstractThe association between dietary nutrient patterns (NPs) and metabolic health status has not been investigated in adolescents. This study aimed to evaluate the relationship between NPs and metabolic health status in Iranian adolescents with overweight and obesity. In this cross-sectional study, 203 obese/overweight adolescents were selected using a multistage mass random sampling method. To assess usual dietary intakes, a validated food frequency questionnaire was applied. Data of anthropometric and blood pressure were collected. Insulin, lipid profile, and glucose levels were determined using fasting blood samples. Two approaches [International Diabetes Federation (IDF) and a combination of IDF with Homeostasis Model Assessment Insulin Resistance (HOMA-IR)] were applied to identify metabolically healthy obese and metabolically unhealthy obese (MUO) adolescents. Participants had a mean age of 13.9 ± 1.61 years and 52.2% of them were girls. Three NPs were identified and labeled as "high minerals and vitamins" (NP1), "high carbohydrate" (NP2) and "high fat and sodium" (NP3). After adjustments for all potential confounders, no significant association was observed between higher adherence to NP1 and NP2 and odds of MUO; however, greater adherence to "high fat and sodium" NP was associated with higher odds of being MUO based on IDF (OR = 3.12; 95% CI 1.19, 8.09) and IDF/HOMA-IR (OR = 2.81; 95% CI 1.02, 7.74) definitions. Stratified analysis revealed that these associations were stronger in boys (versus girls) and obese (versus overweight) adolescents. In conclusion, high adherence to a "high fat and sodium" nutrient pattern was related to elevated chance of being MUO in Iranian adolescents, especially in boys and obese individuals. Therefore, less consumption of trans fatty acids, saturated fatty acids and sodium could be recommended to prevent MUO prevalence especially in boys with obesity.
Recent advances in genetic tools for engineering probiotic lactic acid bacteria
Authors: Mugwanda Kanganwiro , Hamese Saltiel , Van Zyl Winschau F. , Prinsloo Earl , Du Plessis Morne , Dicks Leon M.T. , Thimiri Govinda Raj Deepak B. 
Published: January 2023

Abstract
Synthetic biology has grown exponentially in the last few years, with a variety of biological applications. One of the emerging applications of synthetic biology is to exploit the link between microorganisms, biologics, and human health. To exploit this link, it is critical to select effective synthetic biology tools for use in appropriate microorganisms that would address unmet needs in human health through the development of new game-changing applications and by complementing existing technological capabilities. Lactic acid bacteria (LAB) are considered appropriate chassis organisms that can be genetically engineered for therapeutic and industrial applications. Here, we have reviewed comprehensively various synthetic biology techniques for engineering probiotic LAB strains, such as clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 mediated genome editing, homologous recombination, and recombineering. In addition, we also discussed heterologous protein expression systems used in engineering probiotic LAB. By combining computational biology with genetic engineering, there is a lot of potential to develop next-generation synthetic LAB with capabilities to address bottlenecks in industrial scale-up and complex biologics production. Recently, we started working on Lactochassis project where we aim to develop next generation synthetic LAB for biomedical application.
Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport
Authors: Horackova Hana , Vachalova Veronika , Abad Cilia , Karahoda Rona , Staud Frantisek 
Published: January 2023

AbstractThe placenta represents a non-neuronal organ capable of transporting and metabolizing monoamines. Since these bioactive molecules participate in numerous processes essential for placental and fetal physiology, any imbalance in their levels during pregnancy may affect brain development, projecting a higher risk of behavioral disorders in childhood or adulthood. Notably, the monoamine system in the placenta is a target of various psychoactive drugs and can be disrupted in several pregnancy pathologies. As research in pregnant women poses significant ethical restrictions, animal models are widely employed to study monoamine homeostasis as a mechanism involved in fetal programming. However, detailed knowledge of monoamine transport in the rat placenta is still lacking. Moreover, relatability to the human placental monoamine system is not examined. The present study provides insights into the transplacental monoamine dynamics between maternal and fetal circulation. We show that norepinephrine maternal-to-fetal transport is &lt;4% due to high metabolism within the trophoblast. In contrast, dopamine maternal-to-fetal transport exceeds 25%, likely through passive transport across the membrane. In addition, we show high clearance of norepinephrine and dopamine from the fetal circulation mediated by the organic cation transporter 3 (OCT3). Altogether, we present transcriptional and functional evidence that the in situ rat placenta perfusion represents a suitable model for (patho)physiological investigation of dopamine and norepinephrine homeostasis in the fetoplacental unit. With the rapid advancements in drug discovery and environmental toxicity, the use of rat placenta as a preclinical model could facilitate screening of possible xenobiotic effects on monoamine homeostasis in the placenta.
Functional Hearing Difficulties in Veterans: Retrospective Chart Review of Auditory Processing Assessments in the VA Health Care System
Authors: Papesh Melissa A. , Fowler Lora , Pesa Stephanie R. , Frederick Melissa T. 
Published: January 2023

Purpose:
Approximately 23 million Americans might have functional hearing difficulties (FHDs) that are not well explained by their audiometric thresholds. Clinical management of patients with FHDs is the subject of considerable debate, with few evidence-based guidelines to direct patient care. A better understanding of the characteristics of patients who seek help for FHDs, as well as current audiological management practices, is needed to direct research efforts to the areas greatest opportunity for advancement of clinical care.

Method:
A retrospective chart review was conducted examining the medical records of a random sample of 100 Veterans who underwent auditory processing assessments across the VA Health Care System between 2008 and 2020.

Results:
Patients were young to middle-age, often with previous traumatic brain injury or blast exposure. Mental health, sleep, and pain disorders were common. No consistent relationships emerged between specific patient factors and domains of auditory processing deficits. Low-gain hearing aids were provided to 35 patients, 69% of whom continued wearing their hearing aids for at least 2 years.

Conclusion:
Future research should address the potential overlap in symptoms and treatment for comorbid health conditions and FHDs, as well as the conditions underlying successful hearing aid use in this patient population.
Demands Associated With an Augmentative and Alternative Communication System in Relation to Alternative Forms of Access for Individuals With Motor Impairments
Authors: Sowers Dawn J. , Wilkinson Krista M. 
Published: January 2023

Purpose:
Successful adoption and use of aided augmentative and alternative communication (AAC) must address how to promote fluid, efficient, and organized execution of the motor behavior needed to access the AAC system. A substantial number of people who use AAC have significant motor impairments and require “alternative” access options, such as eye gaze or switch use. Such individuals may be particularly vulnerable to interference from a poorly designed system. However, the inherent demands of alternative access methods have received little direct study. The goal of this tutorial is to offer a clinically and theoretically guided framework for considerations concerning AAC access, with the hope of spurring further discussion and empirical research.

Method:
A framework that draws upon dynamic systems theory was used to illustrate the interactions between the various elements of importance to AAC access. Information and research from the fields of motor learning, developmental dynamic systems theory, AAC, and assistive technology was integrated into this tutorial to examine their applications for alternative AAC access methods.

Results:
The framework illustrated that AAC access involves a complex coordination between individual skills, the demands of the communication environment, the activity being undertaken, and the supports and demands inherent in the AAC system itself.

Conclusions:
Awareness of the many demands that alternative forms of access place on the person who uses them can guide clinicians during assessment and intervention decision making regarding access options for individuals with significant motor impairments. Specific directions for future research are considered.
Treatment of Speech Sound Errors in Cleft Palate: A Tutorial for Speech-Language Pathology Assistants
Authors: Kotlarek Katelyn J. , Krueger Breanna I. 
Published: January 2023

Purpose:
Cleft palate is one of the most common birth defects in the United States. Most of these children receive speech therapy by preschool and school-based clinicians. The purpose of this article is to provide a comprehensive tutorial for speech-language pathology assistants (SLPAs) regarding treatment techniques and principles for children with cleft palate.

Method:
It has been reported that 68% of preschoolers with repaired cleft palate received speech therapy. Preschool and school-based speech-language pathologists (SLPs) have reported a strong desire for practical professional development and continuing education resources regarding treatment of children with cleft palate. Thus, it seems likely that SLPAs may feel similarly unequipped to provide effective treatment for children with cleft palate. Obligatory and learned speech errors commonly found in children with cleft palate are described. Elicitation strategies for compensatory articulations are detailed. The implementation of evidence-based articulation and phonological treatment approaches is described in a step-by-step manner. “Red flags” that may arise during treatment and require input from the supervising SLP are highlighted.

Results:
SLPAs will learn elicitation techniques for compensatory articulations and implement evidence-based treatment approaches to improve the speech accuracy of children with cleft palate.

Conclusion:
It is important for all school-based clinicians to be familiar with speech therapy for individuals with cleft palate.
eHealth Coaching: Counseling Characteristics of Coaches Used With Parents
Authors: Johnson Kylie R. , Muñoz Karen , San Miguel Guadalupe G. , Twohig Michael 
Published: January 2023

Background:
Parents experience challenges managing hearing aids for young children. Counseling strategies can facilitate parent learning and enhance parent–professional partnerships. The purpose of this study was to identify clinician communication behaviors and missed opportunities during an eHealth intervention.

Method:
This study consisted of a qualitative analysis of a subset of the data from a randomized controlled study that included 37 parents of children under 42 months of age who use behind-the-ear hearing aids. These parents participated in coaching via phone calls and viewed instructional videos. The calls were audio-recorded and analyzed for themes within the categories of question asking, responding to parent emotions, engagement in a shared process, and missed opportunities for each category.

Results:
Themes were identified within each category. Trends included greater use of close-ended questions over open-ended questions, frequent responses to parent emotions, and engagement in a shared process through providing information and exploring progress on parent goals. Missed opportunities occurred within each category.

Conclusions:
Coaches' communication behaviors demonstrated support for parent learning that was positively received. Joint planning to address parent challenges was a missed opportunity to support parent behavior changes regarding hearing-aid routines.
A novel cooperative decentralized framework based on peer‐to‐peer energy transactions in networked microgrids to improve the resilience
Authors: Doostizadeh Mohammad , Jalili Hasan , Babaei Abbas 
Published: January 2023

AbstractSevere events such as floods, earthquakes, and hurricanes cause disruption in the distribution networks and cause them to be islanded. In such circumstances, microgrids can be separated from the main grid with the help of their technical and communication infrastructure and transfer energy with each other to reduce their operation and outage costs. Therefore, energy management in a networked microgrid requires a modern operating framework to cause microgrids to supply each other with the energy they need. So, in this paper, a cooperative framework to improve the resilience response of microgrids has been proposed based on peer‐to‐peer energy transactions. In the developed model, since the microgrids are operated in a cooperative and networked manner, they sell energy to each other at the lowest possible cost. Utilizing the developed model, microgrids can improve their resilience response by peer‐to‐peer energy transactions in addition to reduce their operating costs, compared to the independent and non‐cooperative models. To evaluate the efficiency of the proposed method, simulations have performed on a system with 14 microgrids, and the obtained results have compared and analysed. The results obtained have shown the efficiency of the proposed method in increasing resilience and reducing operating costs.
Forbidden emission lines in protostellar outflows and jets with MUSE
Authors: Flores-Rivera Lizxandra , Flock Mario , Kurtovic Nicolás T. , Husemann Bernd , Banzatti Andrea , Ringqvist Simon C. , Kamann Sebastian , Müller André , Fendt Christian , García Lopez Rebeca , Marleau Gabriel-Dominique , Henning Thomas , Carrasco-González Carlos , van Boekel Roy , Keppler Miriam , Launhardt Ralf , Aoyama Yuhiko 
Published: January 2023

Context. Forbidden emission lines in protoplanetary disks are a key diagnostic in studies of the evolution of the disk and the host star. They signal potential disk accretion or wind, outflow, or jet ejection processes of the material that affects the angular momentum transport of the disk as a result.Aims. We report spatially resolved emission lines, namely, [O I]λλ6300, 6363, [N II]λλ6548, 6583, Hα, and [S II]λλ6716, 6730 that are believed to be associated with jets and magnetically driven winds in the inner disks, due to the proximity to the star, as suggested in previous works from the literature. With a resolution of 0.025 × 0.025 arcsec2, we aim to derive the position angle of the outflow/jet (PAoutflow/jet) that is connected with the inner disk. We then compare it with the position angle of the dust (PAdust) obtained from previous constraints for the outer disk. We also carry out a simple analysis of the kinematics and width of the lines and we estimate the mass-loss rate based on the [O I]λ6300 line for five T Tauri stars.Methods. Observations were carried out with the optical integral field spectrograph of the Multi Unit Spectroscopic Explorer (MUSE), at the Very Large Telescope (VLT). The instrument spatially resolves the forbidden lines, providing a unique capability to access the spatial extension of the outflows/jets that make the estimate of the PAoutflow/jetpossible from a geometrical point of view.Results. The forbidden emission lines analyzed here have their origin at the inner parts of the protoplanetary disk. From the maximum intensity emission along the outflow/jet in DL Tau, CI Tau, DS Tau, IP Tau, and IM Lup, we were able to reliably measure the PAoutflow/jetfor most of the identified lines. We found that our estimates agree with PAdustfor most of the disks. These estimates depend on the signal-to-noise level and the collimation of the outflow (jet). The outflows/jets in CIDA 9, GO Tau, and GW Lup are too compact for a PAoutflow/jetto be estimated. Based on our kinematics analysis, we confirm that DL Tau and CI Tau host a strong outflow/jet with line-of-sight velocities much greater than 100 km s−1, whereas DS Tau, IP Tau, and IM Lup velocities are lower and their structures encompass low-velocity components to be more associated with winds. Our estimates for the mass-loss rate,Ṁloss, range between (1.1–6.5) × 10−7–10−8M⊙yr−1for the disk-outflow/jet systems analyzed here.Conclusions. The outflow/jet systems analyzed here are aligned within around 1° between the inner and outer disk. Further observations are needed to confirm a potential misalignment in IM Lup.