bluuebunny/crossref_metadata_2025_split huggingface dataset:
Varsa, E. (2021). Protected Children, Regulated Mothers: Gender and the ‘Gypsy Question’ in State Care in Postwar Hungary, 1949–1956. CEU Press
Authors: Keller Judit Zsuzsanna 
Published: January 2023

This article reviews Eszter Varsa's book Protected Children, Regulated Mothers: Gender and the ‘Gypsy Question’ in State Care in Postwar Hungary, 1949-1956. The volume scrutinizes everyday practices of child protection institutions in postwar Stalinist Hungary embedded in the politics and social tensions of the emerging state socialist regime, such as catch-up industrialisation, women’s rising employment rate and an accompanying restructuring of the relationship between paid work and care work, state intervention in the private realm and an assimilationist policy towards those identified as ‘Gypsy’, meanwhile providing a comparative international perspective. In this regard, Varsa’s book dovetails with ongoing academic discussions of recently renewed political interest in children and parental practices evidenced in the collection of articles in this special issue.
Lived Experience of Iranian Family Caregivers of Tubercular Patients: A Qualitative Study
Authors: Mohebbi Zinat , Dehbozorgi Raziye , Setoodeh Giti , Momennasab Marzieh , Heydari Naval , Shaygan Maryam 
Published: January 2023

Objective. To investigate the lived experience of family caregivers of persons with tuberculosis.
Methods. In this study, the method of hermeneutic phenomenology. Data were collected through online in-depth semi-structured interviews with nine family caregivers of TB patients. The obtained data were thematically analyzed to explain the concept of home care for TB patients through van Manen's 6-step methodology.
Results. After the thematic analysis, three main themes of caregivers'; mental distresses, quality care stasis, andfacilitated care were obtained from 944 primary codes and 11 categories.
Conclusion. Family caregivers of these patients suffer from mental distress. This issue affects the quality and ease of caregiving for these patients. Therefore, policymakers of this area should pay attention to the family caregivers of these patients and attempt to provide support; they should try to improve their quality of life.
Memorias del XI Congreso Colombiano de Fitoquímica
Authors: Holguín Martínez Gloria 
Published: January 2023

Colombia es reconocida como uno de los países con mayor biodiversidad, lo cual representa un gran potencial de desarrollo, sustentado en el hecho de que los recursos biológicos, genéticos y sus derivados representan la materia prima y pueden ser fuente de nuevos productos con alto valor agregado de creciente interés para la industria y el comercio mundial. En este sentido, y con el objetivo de integrar a la comunidad académica y a las cadenas productivas nacionales a los últimos avances en Colombia en la investigación de productos naturales y sus aplicaciones potenciales en las industrias farmacéutica, nutracéutica, cosmética y agropecuaria, el Grupo de Investigación en Sustancias Bioactivas de la Facultad de Química Farmacéutica de la Universidad de Antioquia, realiza el XI Congreso Colombiano de Fitoquímica, Medelln-2011. El desarrollo de la investigación fitoquímica en Colombia, y el avance en la formación universitaria en esta área de conocimiento y sus potencialidades, se convierten en la llave de oro para el estudio y aprovechamiento de los productos naturales orientado al desarrollo social del país. Por estas razones, se han convocado Centros y Grupos de Investigación e investigadores internacionales y nacionales adscritos a instituciones y entidades públicas y privadas, que aporten con sus experiencias investigativas en algunas de las principales temáticas del Congreso, y nos permitan vislumbrar un futuro mejor. Las temáticas en torno a las cuales versará el Congreso cubren aspectos tales como el aislamiento biodirigido y la bioprospección, la farmacología de productos naturales con nuevas aplicaciones terapéuticas, los aceites esenciales, las aplicaciones de los productos naturales en cosméticos, alimentos y agroindustria, la evaluación analítica de plantas medicinales, la biotecnología de productos naturales, la etnofarmacología y la hemisíntesis de productos naturales. Finalmente, con más de 10 plenarias internacionales y conferencistas nacionales de reconocida trayectoria investigativa en el campo de los productos naturales, con más de 250 trabajos presentados por investigadores de 41 Universidades Nacionales y 13 Internacionales, se pretende que el XI Congreso Colombiano de Fitoquimica, consolide entre los académicos, empresarios y visionarios relacionados con el sector, estrategias para el aprovechamiento sostenible de nuestros recursos naturales.

EDISON JAVIER OSORIO DURANGO
Presidente Comité Organizador
Grupo de Investigación en Sustancias Bioactivas - GISB
Universidad de Antioquia
INDONESIA GOVERNMENT GRANTED 7 COMPULSORY LICENCES TO PROMOTE ACCES TO HIV RELATED MEDICINES
Authors: Velásquez Germán 
Published: January 2023

“Starting with Malaysia in 2003, many Asian countries are now taking action to promote cheaper medicines through compulsory licensing, with Indonesia being the most recent case. Recent government actions by Indonesia and India to issue compulsory licenses –CL– are extending the trend in Asia to increase access to cheaper medicines for treating serious ailments, especially those related to HIV/AIDS, cancer and Hepatitis B”. In recent years, a number of countries have issued licenses to improve access to medicines, including, Thailand, Brazil, Malaysia, Zambia, Ecuador and India, among others.
Indonesian President Susilo Bambang Yudhoyono issued a decree on 3rd September 2012 that allows the government to use patents for seven HIV/AIDS and hepatitis B medicines. “We will ensure the availability of good quality, safe and effective generic versions of anti-retroviral and anti-viral drugs,” said HM Subuh, Infectious Disease Control Director at the Indonesian Health Ministry, as quoted in The Jakarta Post on 19th October.
Floodplain soils on the soil map of the Russian Federation, scale 1 : 2.5 M, 1988, in the Russian soil classification, 2004
Authors: Ananko T. V. , Gerasimova M. I. , Savitskaya N. V. 
Published: January 2023

The largest area of taiga gley-differentiated soils on the Soil map of Russian Federation, scale 1:2.5 M, is located in the north of West Siberia. Small areas are dispersed over the northwestern European Russia, Eastern Siberia and the North-East. Interpretation of taiga gley-differentiated soils in terms of Russian soil classification system (2004) is rather ambiguous owing to high diversity of ecological conditions where these soils occur, аs well as variability of soil morphological, chemical, and physicochemical properties in diverse mapping units. Comparing properties of taiga gley-differentiated soils described in the Program of the map (1972) and in regional publications with the diagnostic criteria for soil types in some orders of the Russian classification system made it possible to find adequate names and taxonomic position for these soils. Thus, taiga gley-differentiated soils in the middle and northern taiga of Western Siberia proved to be allocated to several orders: weakly differentiated and gleyed soils with a brown profile were referred to the order of organo-accumulative soils as shallow-peat gleyic soils; their more hydromorphic variants – taiga gley-differentiated shallow-peat soils were defined in the order of gleyzems, as peat gleyzems, soil with morphologically differentiated profile having a particular cryogenic structure were qualified for svetlozems and iron-illuvial gleyic svetlozems in the order of cryometamorpic soils, and for eluvial-metamorphic soils of the same order in case of cryogenic structure was absent. Taiga gley-differentiated soils in their northwestern area are confined to varved clays and correspond to (soddy-)eluvial-metamorphic gleyic soils.
Impact of microbial genome completeness on metagenomic functional inference
Authors: Alberdi Antton , Eisenhofer Raphael , Odriozola Iñaki 
Published: January 2023

Abstract
Inferring the functional capabilities of bacteria from metagenome-assembled genomes (MAGs) is becoming a central process in microbiology. Here we show that the completeness of genomes has a significant impact on the recovered functional signal, spanning all domains of metabolic functions. We identify factors that affect this relationship between genome completeness and function fullness, and provide baseline knowledge to guide efforts to correct for this overlooked bias in metagenomic functional inference.
Insulin resistance measured by High Homeostasis Model Assessment (HOMA) as a Predictor for new onset Diabetes mellitus and diabetic Complications in Non-Diabetic Adults: A KoGES prospective Cohort Study
Authors: Lee Jibeom , Kim Moon-hyun , Jang Ji-Yong , Oh Chang-Myung 
Published: January 2023

Abstract
Aims: Homeostasis model assessment for insulin resistance (HOMA-IR) is a biomarker for Type 2 diabetes mellitus(T2DM). However, the role of HOMA-IR in the non-diabetic is unclear.
Methods: From a prospective community-based cohort of 10,030 individuals, 4,314 individuals younger than 65 years and without diabetes were enrolled and divided into three groups by baseline HOMA-IR tertiles: high (n=1244), moderate (n=1248), and low (n=1822). The primary outcome was new onset T2DM. Secondary outcomes were chronic kidney disease (CKD) and a composite of coronary artery disease, myocardial infarction, and stroke as macrovascular events.
Results:The mean age was 51 years. The prevalence of hypertension and cholesterol and HbA1c were higher in the high HOMA-IR group. New onset T2DM (6.3%) and CKD (12.2%) incidence in the high HOMA-IR group was higher than in the others. The prevalence of macrovascular events did not differ among groups. High-HOMA-IR was an independent risk factor for new onset T2DM (odds ratio 2.07 [1.32-3.25]; p =0.001) and CKD (1.42 [1.08-1.87]; p =0.01).
Conclusions:High HOMA-IR was an early predictor of new onset T2DM and CKD regardless of the HbA1c in non-diabetic individuals. Further research on the specific cut off value will be needed.
Uniaxial attitude control of uncrewed aerial vehicle with thrust vectoring under model variations by deep reinforcement learning and domain randomization
Authors: Osedo Atsushi , Wada Daichi , Hisada Shinsaku 
Published: January 2023

Abstract
The application of neural networks for nonlinear control has been actively studied in the field of aeronautics. Successful techniques have been demonstrated to achieve improved control performance in simulation using deep-reinforcement learning. To transfer the controller learnt in the simulation of real systems, domain randomization is an approach that encourages the adaptiveness of neural networks to changing environments through training with randomized parameters in environments. This approach applies to an extended context, with changing working environments, including model configurations. In previous studies, the adaptive performance of the domain-randomization-based controllers was studied in a comparative fashion over the model variations. To understand the practical applicability of this feature, further studies are necessary to quantitatively evaluate the learnt adaptiveness with respect to the training conditions. This study evaluates deep-reinforcement-learning and the domain-randomization-based controller, with a focus on its adaptive performance over the model variations. The model variations were designed to allow quantitative comparisons. The control performances were examined, with a specific highlight of whether the model variation ranges fell within or exceeded the randomization range in training.
Hypofractionated radiotherapy combined with chemotherapy and Toripalimab for locally recurrent rectal cancer: a single-arm, phase II trial (TORCH-R)
Authors: Wu Ruiyan , Shen Lijun , Zhang Hui , Wang Yan , Wang Yaqi , Zhou Shujuan , Chen Yajie , Xuan Yan , Xu Ye , Cai Sanjun , Xia Fan , Zhang Zhen , Wan Juefeng 
Published: January 2023

Abstract
Background
For patients with locally recurrent rectal cancer (LRRC), R0 resection of pelvic recurrent tumour is most important prognostic factor influencing survival. However, only approximately 40% of patients with recurrent rectal cancer can undergo R0 resection. Recent studies have shown promising synergistic effects of the combination of immunotherapy (PD-1/PD-L1 antibodies) and neoadjuvant chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC). Thus, for LRRC patients, addition of immunotherapy to preoperative CRT is likely to further improve the rate R0 resection and prognosis.
Methods
TORCH-R is a prospective, single-center, single-arm phase II trial of preoperative hypofractionated radiotherapy, chemotherapy and immunotherapy in LRRC. A total of 75 locally recurrent rectal cancer (LRRC) patients will be recruited and receive 25-40Gy/5Fx irradiation or 15-25Gy/5Fx reirradiation, 6 cycles of CAPOX and toripalimab, followed by multidisciplinary team (MDT) for decision: radical surgery, sustained treatment until resectable or exit. The primary endpoint is the R0 resection rate of pelvic recurrent tumour. The secondary endpoints include the overall response rate (ORR), progression-free survival (PFS), overall survival (OS), safety and tolerability.
Discussion
TORCH-R will investigate whether hypofractionated radiotherapy combined with chemotherapy and Toripalimab can achieve better R0 resection rates, good tolerance and prognosis in LRRC patients. This is the first clinical trial to induce immunotherapy and consolidative chemoradiotherapy in LRRC patients.
Trial registration:
Trial Registration Number and Date of Registration: ClinicalTrials.gov NCT05628038, November 17, 2022.
A Partial Order OWA Operator for Solving the OWA Weighing Dilemma
Authors: Li Mingyu , Yue Lizhu , Chen Qinghua 
Published: January 2023

Abstract
Prior weights are necessary for the application of ordered weighted averaging (OWA) operators, but obtaining them is expensive and contentious, which restricts the application of operators. To address the weighting issue, the weight space is used to "replace" the conventional weight vector, and the operator comparison is then extended to a partial order comparison on the weight space. The results show that the partial order OWA operator can be used as long as the weight order is clear, that is, there is no need to take accurate values. The evaluation result is represented by a Hasse diagram. The partial order OWA operator retains the properties of the conventional operator, and the running cost is low. It can be seen from the example that the partial order OWA operator solves the time weight problem. It can compare, sort, and optimize data using the Hasse graph, and it can also implement hierarchical clustering. The comparison results have strong robustness.
What is the effect of different concentration (%) (100%, 80%, 60%, 40%, 20%) of non-heated and heated (at less than 100oC for 10 minutes) garlic (Allium sativum) extract on the zone of inhibition (mm) measured by callipers of Streptococcus mutan modelled by Staphylococcus epidermidis after overnight incubation?
Authors: Lu Jiale 
Published: January 2023

Abstract
I have always wondered how we can use common, easily accessible foods to improve our oral health and protect us against one of the most prevalent diseases, cavities.[1] A combination of bacteria, acid, food debris and saliva in the mouth, forms plaque around the teeth. The acid in plaque, produced by bacteria, demineralises the tooth’s natural enamel (thin layer which covers each tooth, used to protect the inner, fragile areas of the teeth), creating holes on the surface called cavities (dental decay).[2] When fermentable carbohydrates are consumed frequently, the low pH in the plaque selects for aciduric organisms to secrete acid long after the ingestion of food.

[1] “Oral Health Conditions,” 2022, accessed March 5, 2022, https://www.cdc.gov/oralhealth/conditions/index.html#:~:text=Some%20of%20the%20most%20common,one%20cavity%20by%20age%2034..
[2] "Cavities," WebMD, n.d., accessed April 2, 2022, https://www.webmd.com/oral-health/guide/dental-health-cavities.
Alterations in retrobulbar hemodynamics in thyroid eye disease
Authors: Goel Ruchi , SHAH SHALIN , Gupta Swati , Khullar Tamanna , Singh Sonam , Chhabra Mohit , Khanam Samreen , Kumar Sumit , Sharma Pankaj 
Published: January 2023

Abstract
Purpose: To study the orbital perfusion parameters of ophthalmic artery (OA) and central retinal artery (CRA) in inactive TED and the changes following surgical decompression.
Methods: Non-randomised clinical trial. 24 inactive moderate-to-severe TED orbits of 24 euthyroid cases underwent surgical decompression and examined again at 3 months. The peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistivity index (RI) of OA and CRA were evaluated using color doppler imaging and normative database was established using 18 healthy controls.
Results: The mean age was 39.38 +12.56 years and male: female ratio was 1: 1.18. Intraocular pressure was higher, and CRA – PSV, CRA – RI, OA – PSV, and OA – EDV were lower in TED in comparison to heathy orbits. The CRA – PSV, CRA – EDV, OA – PSV, and OA – EDV negatively correlated with proptosis and duration of thyroid disease. The area under curve of OA – PSV (95% CI:0.964-1.000, p<0.001) and OA – EDV (95% CI:0.699-0.905, p<0.001) helped in differentiating TED orbits from healthy controls, and in predicting the severity of disease. Post decompression, CRA – PSV, CRA – EDV, OA – PSV, and OA – EDV improved, with decrease in CRA – RI and OA – RI in both lipogenic and myogenic orbitopathy.
Conclusions: The orbital perfusion is reduced in inactive TED. The changes in OA flow velocities can help in differentiating inactive TED from healthy orbits and progression of TED. Sequential orbital CDI of OA and CRA can serve as an objective tool for case selection and monitoring response to surgical decompression.
Nuclear Complement C3b Promotes Paclitaxel Resistance by assembling the SIN3A/HDAC1/2 complex in non-small cell lung cancer
Authors: Wang Xiaochao , Hao Yan , Chen Jianfeng , Ding Peipei , Lv Xinyue , Zhou Danlei , Li Ling , Li Luying , Xu Yanqing , Zhu Yumeng , Zhang Wei , Chen Lu , Liao Tian , He Xianghuo , JI Qing-HaI , Hu Weiguo 
Published: January 2023

Abstract
In addition to the classical role as a serum effector system of innate immunity, accumulating evidence suggests that intracellular complement components have indispensable functions in immune defense, T cell homeostasis, and tumor cell proliferation and metastasis. Here, we revealed that complement component 3 (C3) is remarkably upregulated in paclitaxel (PTX)-resistant non-small cell lung cancer (NSCLC) cells and that knockdown of C3 promoted PTX-induced cell apoptosis, sensitizing resistant cells to PTX therapy. Ectopic C3 decreased PTX-induced apoptosis and induced resistance to PTX treatment in original NSCLC cells. Interestingly, C3b, the activated fragment of C3, was found to translocate into the nucleus and physically associate with the HDAC1/2-containing SIN3A complex to repress the expression of GADD45A, which plays an important role in cell growth inhibition and apoptosis induction. Importantly, C3 downregulated GADD45A by enhancing the binding of the SIN3A complex with the promoter of GADD45A, thus decreasing the H3Ac level to compress chromatin around the GADD45A locus. Subsequently, ectopic GADD45A promoted PTX-induced cell apoptosis, sensitizing resistant cells to PTX therapy, and insufficiency of GADD45A in original cancer cells induced resistance to PTX treatment. These findings identify a previously unknown nucleus location and oncogenic property for C3 in chemotherapy and provide a potential therapeutic opportunity to overcome PTX resistance.
Microfluidic devices to analyze the response of sphere-forming stem-like populations to chemotherapeutic drugs
Authors: Agüero Eduardo Imanol , Belgorosky Denise , García-Silva Julio Israel , Booth Ross , Lerner Betiana , Pérez Maximiliano Sebastián , Eiján Ana María 
Published: January 2023

Abstract
Microfluidic platforms for clinical use are a promising translational strategy for cancer research specially for drug screening. Identifyng Cancer Stem Cells (CSC) using sphere culture techniques in microfluidic devices (MDs) showed to be better reproducing physiological responses than other in vitro models and allow the optimization of samples and reagents. We evaluated individual spheres proliferation and stemness towards chemotherapeutic treatment (CT) with doxorubicin and cisplatin in bladder cancer cell lines (MB49-I and J82) cultured in MDs used as CSC treatment response platform. Our results confirm the usefulness of this device to evaluate the CT effect in sphere-forming efficiency, size and growth rate from individual spheres within MDs and robust information comparable to conventional culture plates was obtained. The expression of pluripotency genetic markers (Oct4, Sox2, Nanog and CD44) could be analyzed by qPCR and immunofluorescence in spheres growing directly in MDs. MDs are a suitable platform for sphere isolation from tumor samples and can provide information about CT response. Microfluidic-based CSC studies could provide information about treatment response of cancer patients from small samples and can be a promising tool for CSC-targeted specific treatment with potential in precision medicine.
Endocytosis-mediated entry of a caterpillar effector into plants is countered by Jasmonate
Authors: Chen Fang-Yan , Yan Zi-Wei , Zhang Xian , Cai Wen-Juan , Chen Chun-Yu , Liu Jie , Wu Man-Ni , Liu Ning-Jing , Ma Bin , Wang Muyang , Chao Dai-Yin , Gao Caiji , Mao Ying-Bo 
Published: January 2023

Abstract
Both insects and pathogens release effectors that are transferred into plant cells and weaken the host defense or immune response. While the imports of some bacterial and fungal effectors into plants have been reported, how caterpillar effectors enter plant cells remains a mystery. Here, using live cell imaging and real-time protein tracking, we show that HARP1, an effector from oral secretions of cotton bollworm (Helicoverpa armigera) which is previously reported to interfere with defense hormone jasmonate (JA) signaling output in host plants, enters plant cells via protein-mediated endocytosis. The interactions of HARP1 with vesicle trafficking components including CTL1, PATL2 and TET8 are essential for its entry. Notably, JA restricts HARP1 import by inhibiting endocytosis and HARP1 loading on endosomes. Taken together, the effector and JA set up a defense and counter-defense loop in the arm race between plants and insects. Our study unveils a new paradigm for the plant-insect interaction.