bluuebunny/crossref_metadata_2025_split huggingface dataset:
Database of daily Lagrangian Arctic sea ice parcel drift tracks with coincident ice and atmospheric conditions
Authors: Horvath Sean , Boisvert Linette , Parker Chelsea , Webster Melinda , Taylor Patrick , Boeke Robyn , Fons Steven , Stewart J. Scott 
Published: February 2023

AbstractSince the early 2000s, sea ice has experienced an increased rate of decline in thickness, extent and age. This new regime, coined the ‘New Arctic’, is accompanied by a reshuffling of energy flows at the surface. Understanding of the magnitude and nature of this reshuffling and the feedbacks therein remains limited. A novel database is presented that combines satellite observations, model output, and reanalysis data with sea ice parcel drift tracks in a Lagrangian framework. This dataset consists of daily time series of sea ice parcel locations, sea ice and snow conditions, and atmospheric states, including remotely sensed surface energy budget terms. Additionally, flags indicate when sea ice parcels travel within cyclones, recording cyclone intensity and distance from the cyclone center. The quality of the ice parcel database was evaluated by comparison with sea ice mass balance buoys and correlations are high, which highlights the reliability of this database in capturing the seasonal changes and evolution of sea ice. This database has multiple applications for the scientific community; it can be used to study the processes that influence individual sea ice parcel time series, or to explore generalized summary statistics and trends across the Arctic.
Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
Authors: Ribault Alexandre , Benadjaoud Mohamed Amine , Squiban Claire , Arnaud Laurent , Judicone Coralie , Leroyer Aurélie S. , Rousseau Alexandra , Huet Christelle , Guha Chandan , Benderitter Marc , Lacroix Romaric , Flamant Stephane , Chen Emily I. , Simon Jean-Marc , Tamarat Radia 
Published: February 2023

AbstractIn a large retrospective study, we assessed the putative use of circulating microvesicles (MVs), as innovative biomarkers of radiation toxicity in a cohort of 208 patients with prostate adenocarcinoma overexposed to radiation. The level of platelet (P)-, monocyte (M)- and endothelial (E)-derived MVs were assessed by flow cytometry. Rectal bleeding toxicity scores were collected at the time of blood sampling and during the routine follow-up and were tested for association with MVs using a multivariate logistic regression. MVs dosimetric correlation was investigated using dose volume histograms information available for a subset of 36 patients. The number of PMVs was significantly increased in patients with highest toxicity grades compared to lower grades. Risk prediction analysis revealed that increased numbers of PMVs, and an increased amount of MMVs relative to EMVs, were associated with worst rectal bleeding grade compared to the time of blood sampling. Moreover, a significant correlation was found between PMV and MMV numbers, with the range of doses up to the median exposure (40 Gy) of bladder/rectum and anterior rectal wall, respectively. MVs could be considered as new biomarkers to improve the identification of patients with high toxicity grade and may be instrumental for the prognosis of radiation therapy complications.
Caloric restriction increases the resistance of aged heart to myocardial ischemia/reperfusion injury via modulating AMPK–SIRT1–PGC1a energy metabolism pathway
Authors: Guo Zhijia , Wang Meng , Ying Xiaodong , Yuan Jiyu , Wang Chenggang , Zhang Wenjie , Tian Shouyuan , Yan Xiaoyan 
Published: February 2023

AbstractA large number of data suggest that caloric restriction (CR) has a protective effect on myocardial ischemia/reperfusion injury (I/R) in the elderly. However, the mechanism is still unclear. In this study, we created the I/R model in vivo by ligating the mice left coronary artery for 45 min followed by reperfusion. C57BL/6J wild-type mice were randomly divided into a young group fed ad libitum (y-AL), aged fed ad libitum (a-AL) and aged calorie restriction group (a-CR, 70% diet restriction), and fed for 6 weeks. The area of myocardial infarction was measured by Evan’s blue-TTC staining, plasma cholesterol content quantified by ELISA, fatty acids and glucose measured by Langendorff working system, as well as protein expression of AMPK/SIRT1/PGC1a signaling pathway related factors in myocardial tissue detected by immunoblotting. Our results showed that CR significantly reduced infarct size in elderly mice after I/R injury, promoted glycolysis regardless of I/R injury, and restored myocardial glucose uptake in elderly mice. Compared with a-AL group, CR significantly promoted the expression of p-AMPK, SIRT1, p-PGC1a, and SOD2, but decreased PPARγ expression in aged mice. In conclusion, our results suggest that CR protects elderly mice from I/R injury by altering myocardial substrate energy metabolism via the AMPK/SIRT1/PGC1a pathway.
Molecular phylogeny reveals distinct evolutionary lineages of the banded krait, Bungarus fasciatus (Squamata, Elapidae) in Asia
Authors: Biakzuala Lal , Lalremsanga Hmar T. , Santra Vishal , Dhara Arindam , Ahmed Molla T. , Mallick Ziniya B. , Kuttalam Sourish , Amarasinghe A. A. Thasun , Malhotra Anita 
Published: February 2023

AbstractThe banded krait, Bungarusfasciatus is a widespread elapid snake, likely to comprise several distinct species in different geographic regions of Asia. Therefore, based on molecular phylogenetics and comparative morphology data, we present an overview of the systematic composition of the species to delimit potential biogeographic boundaries. Our phylogenetic analyses, based on four mitochondrial genes, reveal the existence of at least three evolutionary lineages within B.fasciatus, corresponding to Indo-Myanmar, Sundaic and eastern Asian lineages. We are convinced that there are at least three taxonomic entities within the nomen B.fasciatus and restrict the distribution of B.fasciatus sensu stricto to the Indo-Myanmar region. We also provide additional natural history data of the taxon from eastern India. Finally, we advocate further studies to establish the degree of reproductive isolation among these diverging evolutionary lineages and to reassess the systematic status of this species complex especially the Sundaic and eastern Asian lineages.
Impact of lamina-open side on unilateral open door laminoplasty in patients with degenerative cervical myelopathy
Authors: Kang Kyung-Chung , Im Sang-Kyu , Lee Jung-Hee , Lee Ki Young , Seo Dong-Uk , Hwang In-Uk 
Published: February 2023

AbstractSurgeons should select one side for cervical unilateral open door laminoplasty (UODL). However, few reports suggest proper guidelines for deciding which side to open. The aim of this study is to evaluate the impact of opening side in UODL on dominant cord compressive or symptomatic side. 193 degenerative cervical myeloradiculopathy patients with followed-up more than 2 years were enrolled. In all cases, UODL was performed uniformly on the right side. Patients were sub-grouped based on preoperative dominant 3 characteristics: cord compression, myelopathy symptom and radiculopathy symptom (right, symmetric, left). Pre- and postoperative radiographic and clinical parameters and incidence of postoperative C5 palsy were analyzed and compared among the groups. According to dominant compressive side, there were no significant differences in postoperative radiographic and clinical parameters among three groups. According to dominant myelopathy or radiculopathy symptom side, there were no significant differences of all radiographic and clinical parameters postoperatively, except slightly lower neck VAS in groups of preoperative right dominant myelopathy or radiculopathy symptom side at postoperative 1 month. C5 palsies occurred in twelve patients (6.2%), but the incidences were not different among the groups. Therefore, when performing UODL, the choice of lamina opening side can be left to surgeon’s preference.
Red cabbage extract-mediated colorimetric sensor for swift, sensitive and economic detection of urease-positive bacteria by naked eye and Smartphone platform
Authors: Celik Cagla , Demir Naim Yagiz , Duman Memed , Ildiz Nilay , Ocsoy Ismail 
Published: February 2023

AbstractThe bacterial pathogens have caused various serious infectious diseases in the human body, and even some threats to human life by leading to deaths. Enterobacteriaceae species especially urease positive ones, Proteus mirabilis (P. mirabilis) and Klebsiella pneumoniae (K. pneumoniae), show resistance to antibiotics and cause respiratory and urinary tract infections. We have developed natural indicator-incorporated colorimetric urease tests with a naked eye and smartphone readout to rapidly, sensitively and economically detect P. mirabilis and K. pneumoniae. We utilized anthocyanin found as a predominant component in red cabbage (Brassica oleracea) extract as a natural pH indicator instead of toxic and synthetic indicators. As a mechanistic explanation for the detection of P. mirabilis and K. pneumoniae, urease enzymes secreted from the P. mirabilis and K. pneumoniae hydrolyze urea to produce ammonia (NH3), which increases the pH value of the reaction environment and leads to deprotonation from anthocyanins. The changes in the molecular structure and electronic structure of anthocyanins are responsible for revealing many different colors. We demonstrated how some reaction parameters including the concentration of the bacteria (colony-forming unit, CFU), the concentration of anthocyanin in the tests, initial color and pH values (pHs) of the tests influence their detection performance. We further developed a 3D-printed smartphone platform with smartphone based digital image processing software to improve the detection limit and shorten the detection time. We claim that natural indicator-incorporated rapid urease tests providing colorimetric readout evaluated by the human eye and smartphone imaging processing has great potential in practical use and they can be implemented in clinics.
The onset of rare earth metallosis begins with renal gadolinium-rich nanoparticles from magnetic resonance imaging contrast agent exposure
Authors: DeAguero Joshua , Howard Tamara , Kusewitt Donna , Brearley Adrian , Ali Abdul-Mehdi , Degnan James H. , Jett Stephen , Watt John , Escobar G. Patricia , Dokladny Karol , Wagner Brent 
Published: February 2023

AbstractThe leitmotifs of magnetic resonance imaging (MRI) contrast agent-induced complications range from acute kidney injury, symptoms associated with gadolinium exposure (SAGE)/gadolinium deposition disease, potentially fatal gadolinium encephalopathy, and irreversible systemic fibrosis. Gadolinium is the active ingredient of these contrast agents, a non-physiologic lanthanide metal. The mechanisms of MRI contrast agent-induced diseases are unknown. Mice were treated with a MRI contrast agent. Human kidney tissues from contrast-naïve and MRI contrast agent-treated patients were obtained and analyzed. Kidneys (human and mouse) were assessed with transmission electron microscopy and scanning transmission electron microscopy with X-ray energy-dispersive spectroscopy. MRI contrast agent treatment resulted in unilamellar vesicles and mitochondriopathy in renal epithelium. Electron-dense intracellular precipitates and the outer rim of lipid droplets were rich in gadolinium and phosphorus. We conclude that MRI contrast agents are not physiologically inert. The long-term safety of these synthetic metal–ligand complexes, especially with repeated use, should be studied further.
Parametric study of pulsed nanosecond laser interaction with carbon-nanotube composite bipolar plate for PEMFCs
Authors: Musse Dawit , Lee Dongkyoung 
Published: February 2023

AbstractA laser processing technique is proposed for the processing of a 2.5 mm thick carbon nanotube (CNT) composite bipolar plate for proton exchange membrane fuel cells (PEMFCs). This study aims to understand laser interaction with the CNT composite plate experimentally using a pulsed nanosecond laser. Penetration depth, top width, spatter width, and overall physical morphologies are studied. Scanning electron microscope (SEM) and 3D Scanning Confocal Microscope were used for observation and measurements. Based on that, a parametric investigation is conducted and reported systematically. Most importantly, the pulse repetition rate presents a unique nature of interaction that resulted in a critical repetition rate distinguishing three operational regimes. The physical and chemical properties of the regimes are further analyzed by Vickers microhardness testing and energy dispersive X-ray (EDX) analyses performed on the surface and cross-section of each specimen. The results reveal that the pulse repetition rate introduces changes in mechanical properties and chemical compositions in the vicinity of the processed region. In conclusion, lower pulse repetition should be favored for less impact on mechanical properties, chemical composition, and morphological aspects.
Influence of a transient spark plasma discharge on producing high molecular masses of chemical products from l-cysteine
Authors: Farhadi Masume , Sohbatzadeh Farshad 
Published: February 2023

AbstractCold atmospheric pressure plasmas are considered a forthcoming method in many research areas. Plasma modification of biomolecules has received much attention in addition to plasma-treated biomaterials. Hence, in this work, we operated a transient spark plasma (TSP) discharge to study its effect on the l-cysteine chemical structure. the TSP was configured in a pin-to-ring electrode arrangement and flowed by Ar gas. We also investigated the effect of two chemicals; dimethyl sulfoxide (DMSO) and hydrogen peroxide (H2O2) by the bubbling method to show how they can change the creation of new chemical bioproducts. Ultraviolet–Visible absorption spectroscopy, Fourier transform infrared spectroscopy and Liquid chromatography–mass spectroscopy were used to investigate any changes in chemical bonds of cysteine structure and to depict the generation of new biomolecules. Based on the displayed results plasma-generated reactive species had a great role in the chemical structure of the cysteine. Entering DMSO and H2O2 into the plasma caused the creation of new products and the heaviest biomolecule was produced by the simultaneous addition of DMSO and H2O2. The results also predicted that some chemical products and amino acids with a higher value molecular masse produced from the polymerization process of cysteine solution. The strong oxidation process is responsible for the heavy chemical compounds.
Metabolomic profiling in kidney cells treated with a sodium glucose-cotransporter 2 inhibitor
Authors: Jo Hyung Ah , Seo Jong-Hyun , Lee Sunhwa , Yu Mi-yeon , Bae Eunjin , Kim Dong Ki , Kim Yon Su , Kim Da Jung , Yang Seung Hee 
Published: February 2023

AbstractWe aimed to determine the metabolomic profile of kidney cells under high glucose conditions and following sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment. Targeted metabolomics using the Absolute IDQ-p180 kit was applied to quantify metabolites in kidney cells stimulated with high glucose (25 and 50 mM) and treated with SGLT2 inhibitor, dapagliflozin (2 µM). Primary cultured human tubular epithelial cells and podocytes were used to identify the metabolomic profile in high glucose conditions following dapagliflozin treatment. The levels of asparagine, PC ae C34:1, and PC ae C36:2 were elevated in tubular epithelial cells stimulated with 50 mM glucose and were significantly decreased after 2 µM dapagliflozin treatment. The level of PC aa C32:0 was significantly decreased after 50 mM glucose treatment compared with the control, and its level was significantly increased after dapagliflozin treatment in podocytes. The metabolism of glutathione, asparagine and proline was significantly changed in tubular epithelial cells under high-glucose stimulation. And the pathway analysis showed that aminoacyl-tRNA biosynthesis, arginine and proline metabolism, glutathione metabolism, valine, leucine and isoleucine biosynthesis, phenylalanine, tyrosine, and tryptophan biosynthesis, beta-alanine metabolism, phenylalanine metabolism, arginine biosynthesis, alanine, aspartate and glutamate metabolism, glycine, serine and threonine metabolism were altered in tubular epithelial cells after dapagliflozin treatment following 50 mM glucose compared to those treated with 50 mM glucose.
Clinical characteristics depending on magnetic resonance imaging patterns in idiopathic isolated optic neuritis
Authors: Park Sang Min , Kim Ungsoo Samuel 
Published: February 2023

AbstractTo investigate differences in clinical features based on magnetic resonance imaging (MRI) in idiopathic isolated optic neuritis patients. We retrospectively analyzed 68 eyes of 59 patients diagnosed with optic neuritis and showed inflammatory findings indicative of optic neuritis on MRI. We investigated clinical features, such as the presence of accompanying pain, visual acuity, and optic disc swelling. Optic disc swelling was classified as normal, mild, or severe. The MRI results were divided into intraorbital, intracanalicular, and whole optic nerve according to the lesion, and these were compared and analyzed with clinical features. The study included 29 men and 30 women, with a mean age of 42.6 ± 16.6 years. Among 59 patients, 48 (81.4%) complained of pain. Optic disc swelling was not observed in 48.5% of patients (33 eyes). Inflammatory changes were the most common in the intraorbital region (33 eyes), intracanalicular region (20 eyes), and the entire optic nerve (15 eyes). There was no statistical difference in the pain pattern according to the location of the lesion (p = .677), but when inflammation was present in the entire optic nerve, optic disc swelling was severe (p = .023). The initial and final visual acuity did not significantly correlate with the MRI pattern, presence of pain, or optic disc swelling (p = .156, p = .714, and p = .436). The MRI contrast enhancement pattern was associated with optic disc swelling but was not associated with pain or initial visual acuity. It should be noted that it is insufficient to judge the clinical features of optic neuritis based on MRI findings.
Haematological indices and immune response profiles in dogs naturally infected and co-infected with Dirofilaria repens and Babesia canis
Authors: Wężyk Dagmara , Romanczuk Karolina , Rodo Anna , Kavalevich Dziyana , Bajer Anna 
Published: February 2023

AbstractCo-infections withDirofilaria repensandBabesia canisare rarely reported in the literature and there is very limited knowledge of their impact on canine health. Central Poland is endemic for both parasites, posing a risk of co-infections in dogs. To evaluate the impact of co-infection withB. canisandD. repenson canine health, four groups of dogs were examined: healthy dogs, dogs infected withB. canis, dogs infected withD. repensand dogs co-infected with both species. Blood parameters indicative of anaemia, kidney and liver damage were analysed statistically. Additionally, expression levels of immune response genes were quantified and compared, to define the type of immune response typically encountered in single- and co-infections. In dogs infected withD. repens, no major alterations in blood parameters were observed. Dogs infected withB. canissuffered from anaemia, kidney and liver insufficiency. In contrast, dogs co-infected withD. repensandB. canisshowed milder alternation in blood biochemical parameters associated with liver (ALP activity) and kidney (serum urea and creatinine levels) dysfunction, compared to dogs infected only withB. canis. The expression of genes associated with cellular (Th1-mediated) (STAT4andINF-γ), humoral (Th2-mediated) (STAT6,GATA3,SOCS3, IL-13) and regulatory (IL-10) responses was quantified. For this analysis, dogs infected withB. caniswere divided into two groups—‘Babesia 1’ (mild babesiosis), ‘Babesia 2’ (severe babesiosis). All the tested factors, exceptINF-γ,were found to be expressed in dogs infected withD. repens. In ‘Babesia 1’ dogs, expression ofGATA3was highest, while in ‘Babesia 2’—INF-γandSOCS3dominated.IL-13expression was predominant in dogs infected withD. repens, andSTAT6andIL-10predominated in dogs with co-infections.
Association between urinary iodine concentration and the risk of papillary thyroid cancer by sex and age: a case–control study
Authors: Hwang Yerin , Oh Hyun-Kyung , Chung Jae Hoon , Kim Sun Wook , Kim Jung-Han , Kim Jee Soo , Shin Myung-Hee 
Published: February 2023

AbstractPrevious studies on dietary iodine intake and the risk of papillary thyroid cancer (PTC) have demonstrated inconsistent results. We aimed to evaluate the association between urinary iodine concentration (UIC), a surrogate biomarker for dietary iodine intake, and the risk of thyroid cancer stratified by sex and age in an iodine-sufficient area. A hospital-based case–control study was conducted in Seoul, South Korea. A total of 492 cases of newly diagnosed PTC and 595 controls were included. Compared with the lowest quartile of creatine-adjusted UIC (< 159.3 μg/gCr), the highest quartile (≥ 1037.3 μg/gCr) showed an increased risk of PTC (odds ratio [OR] 1.49, 95% confidence interval [CI] 1.04–2.13), especially in those who were < 45 years old (ptrend = 0.01) compared with those who were ≥ 45 years old (ptrend = 0.48). For those who were < 45 years old, a positive association between creatinine-adjusted UIC and the risk of PTC was observed in both men (q4 vs. q1, OR 4.27, 95% CI 1.14–18.08) and women (OR 1.97, 95% CI 1.04–3.78). For those who were ≥ 45 years old, no association was found in any sex. Creatinine-adjusted UIC was positively associated with the risk of PTC, especially in those who were younger than 45 years for both men and women.
The restoration and erection of the world’s first elevated obelisk
Authors: Saleh Atef M. , Mourad Sherif A. , Elanwar Hazem H. , Metwally Omar K. , Zeidan Eissa , Adam Mahmoud A. , Ameen Mostafa F. , Helal Khalid R. , Sholqamy Mohamed S. , Allam Hussien E. , Ismael Mohamed A. , Mostafa Khaled A. , Helal Hany M. , Elbanhawy Amr Y. , Grosse Christian U. , Bakhoum Mourad M. , Farag Mousa M. , Matar Hani B. , Eltobgy Hanan H. , Moharram Moustafa I. , Marzouk Mohamed M. , Metawie Mahmoud S. , Ali Mohamed R. , Sayed Ashraf N. , Mohamed Mohamed G. , Elkarmoty Mohamed M. 
Published: February 2023

AbstractObelisks presented an important element in the architecture of ancient Egypt. This research is concerned with the re-erection of an obelisk that belongs to the famous Pharoah Ramses II. It was found broken and was transported to the Grand Egyptian Museum for restoration and display. An observation of Ramses II Cartouche at the bottom side of the obelisk base inspired the authorities to provide an innovative architectural design to display the obelisk elevated. The supporting structure was designed to allow the visitors to walk underneath the obelisk and observe Ramses II's signature. The idea of elevating the obelisk presented several challenges including evaluating the obelisk's current condition, restoration and fixation methodology, structural stability, and uncertainties of material characteristics, amongst others. To control the obelisk deformations under lateral loading, state-of-the-art base isolators were introduced. For the task to be achieved, a multidisciplinary team including historians, conservators, archaeologists, architects, and engineers with different specialties was appointed. The team performed the task successfully and currently, the obelisk stands at the entrance piazza of the Grand Egyptian Museum representing the world’s first elevated obelisk.