bluuebunny/crossref_metadata_2025_split huggingface dataset:
SICKLE CELL TRAIT, CLINICAL MANIFESTATIONS AND OUTCOMES: A CROSS-SECTIONAL STUDY
Authors: Vargas-Hernández Diego A , Uscategui-Ruiz Adriana Catalina , Prada-Rueda Andrés Jesus , Romero-Sánchez Consuelo 
Published: March 2023

Introduction: Sickle cell trait (SCT) is an autosomal recessive blood disorder in which patients are heterozygous carriers for hemoglobin S (HbAS) and are usually asymptomatic. We performed a descriptive analysis of clinical manifestations and outcomes associated with SCT.
Methods: This was a descriptive, cross-sectional study that included patients with SCT from 2014 to 2020 at Hospital Militar Central, the reference center of the Military forces in Bogota, Colombia.
Results: Of 647 hemoglobin electrophoresis analyzed, we identified 51 patients with SCT, including 43 males (84.3%) and eight females (15.7%), with a median age of 22 years (IQR 15–36 years). Of these, 28 (54.8%) were Afro-Colombian, and 23 (45.1%) were Colombian mestizos. Twenty-four patients (47.1%) were asymptomatic, and Twenty-seven patients (52.9%) were symptomatic (systemic complications); splenic complications were the most important (85.2%), p=0.0005, and there was a wide spectrum of splenic complications. We found significant elevations in leukocytes, bilirubin, LDH, and CRP. Eighteen patients (66.7%) received medical management, five patients (18.5%) required splenectomy, and only 5.9% of patients were sent for genetic counseling.
Conclusions: Splenic complications were the most relevant in symptomatic patients. Most patients received medical treatment, and 18.5% of patients required splenectomy. Our results reflect the absence of redirection of these patients to genetic counseling.
QUANTITATIVE ANALYSIS OF LIVER IRON DEPOSITION BASED ON DUAL-ENERGY CT IN THALASSEMIA PATIENTS
Authors: Xu Fengming , Tang Cheng , Huang Yiling , Liang Linlin , Huang Fuling , Yang Gaohui , Peng Peng 
Published: March 2023

Objective: To explore the feasibility and accuracy of liver iron deposition based on dual-energy CT in thalassemia patients.
Materials and methods: 105 thalassemia patients were examined with dual-energy CT and MR liver scanning. Dual-energy CT was performed to measure CT values on 80kVp, 140kVp and virtual iron content (VIC) imaging, ΔH was figured out by the difference CT values between 80kVp and 140kVp. Using the liver iron concent (LIC) obtained by FerriScan as standard setting, the correlation between CT measurements and LIC was compared. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance for dual-energy CT in liver iron quantification and stratification.
Results: The correlation analysis between CT measurements and LIC showed that 80kVp, 140kVp, VIC and ΔH all had a high-positive correlation with LIC (P<0.001). The correlation analysis among different degree groups of VIC, ΔH and LIC showed that the normal, moderate, severe groups of VIC and ΔH had moderate or high positive correlations with that of LIC (P<0.01), but the mild group had no correlation (P>0.05). ROC analysis revealed that the corresponding optimal cutoff value of VIC were -2.8, 6.3,11.9 HU (corresponds to 3.2,7.0,15.0 mg/g dry weight) respectively, while the ΔH were 5.1, 8.4, 17.8HU, respectively. The area under the receiver operating characteristic curves (AUCs) for both VIC and ΔH increased with the increase of LIC thresholds.
Conclusion: Dual-energy CT can accurately evaluate liver iron deposition quantification and stratification, which contribute to predict the status of liver iron deposition of thalassemia patients.
Levofloxacin prophylaxis omission in acute myeloid leukemia during post induction aplasia: a single center study
Authors: Urbino Irene , Frairia Chiara , Busca Alessandro , Corcione Silvia , D'Ardia Stefano , Dellacasa Chiara Maria , Giai Valentina , Secreto Carolina , Freilone Roberto , De Rosa Francesco Giuseppe , Aydin Semra , Ciccone Giovannino , Rosato Rosalba , Cerrano Marco , Audisio Ernesta 
Published: March 2023

Background and objectives: acute myeloid leukemia (AML) patients are at high risk of infections during post induction neutropenia. Recently, the role of antibacterial prophylaxis has been reconsidered due to concerns about the emergence of multi-resistant pathogens. Aim of the present study was to evaluate the impact of prophylaxis omission on the rate of induction death (primary endpoint), neutropenic fevers, bloodstream infections (BSIs), resistant pathogens BSIs and septic shocks (secondary endpoints). Methods: we performed a retrospective single center study including 373 AML patients treated with intensive induction chemotherapy, divided in two groups according to levofloxacin prophylaxis given (group A, gA) or not (group B, gB). Results: neutropenic fever was observed in 91% of patients in gA and 97% in gB (OR 0.35, IC95% 0.08 – 1.52, p=0162).The rate of BSIs was 27% in gA compared to 34% in gB (OR 0.69, 0.38 – 1.25, p=0.222). Induction death rate was 5% in gA and 3% in gB (OR 1.50, 0.34 – 6.70, p=0.284). Fluoroquinolones (FQ) resistant pathogens were responsible for 59% of total BSIs in gA and 22% in gB (OR 5.07, 1.87 – 13.73, p=0.001); gram-negative BSIs due to multi-drug resistant organisms were 31% in gA and 36% in gB (OR 0.75, 0.15 – 3.70, p=0.727). Conclusions: levofloxacin prophylaxis omission was not associated with an increased risk of induction death. Cumulative incidence of neutropenic fever was higher in non-prophylaxis group, while no difference was observed for BSIs. In the prophylaxis group we observed a higher incidence of FQ resistant organisms.
Evangelism as an invitation to missional discipleship in the kingdom of God
Authors: Coetzee Frederik R. , Nel Malan , Knoetze Johannes J. 
Published: March 2023

Evangelism, for various reasons, is once again back on the agenda of the church and theology. As a result of negative experiences and practices of evangelism in the past, it is now necessary to rediscover evangelism in a post-Christendom context to enable the theological recovery of evangelism. This new understanding of evangelism can then contribute to the recovery of authentic practices in spreading the good news. To achieve this, evangelism must be rediscovered as essential to mission (participation in the missio Dei). Further to this, evangelism is rediscovered as an invitation to missional discipleship in the coming of the kingdom of God (missional discipleship as participation in the coming of the kingdom). This research was based on the starting point that evangelism takes place through an integrated missional congregation as the evangelist. This implies that evangelism is not an additional extra practice by a few members but an integral part of congregational ministry. Evangelism is then understood and integrated holistically as martyria by the entire faith community. The gospel of the kingdom is then embodied in their faithful presence (being), loving service (deeds) and words of hope at appropriate times (speaking). This holistic approach will free evangelism from reductionisms and dichotomies that have added to the fact that evangelism has fallen out of favour. These practices of evangelism are determined by the theology (content) and serviceable style of Jesus and contextually discerned in faith as participating in God’s mission. The empirical research was based on 49 questionnaires received from 43 Dutch Reformed (DR) congregations from the Northern Synods and 6 other churches. The qualitative research comprised structured interviews with 10 pastors from participating DR congregations. Simple random sampling was used to select the participants of the study.Intradisciplinary and/or interdisciplinary implications: This research was conducted from the perspectives of practical theology and missiology. However, it also leaned into systematic theology (dogmatics) about missional ecclesiology and the identity of the church. The understanding of the integrated missional congregation (faith community) made use of systems theory, which is an interdisciplinary approach. The ethics of the practices of evangelism have points of contact with ethics.
God-talk and the question of being human
Authors: Bentley Wessel 
Published: March 2023

The doctrine of the Trinity has, for centuries, dominated God-talk and the view of humanity within the framework of sin and salvation. This article investigated how God-talk, specifically the doctrine of the Trinity in Christian theology, speaks about both the nature of the Godhead and who we are as human beings. The article followed the outlines of our understanding of God’s transcendence, immanence and presence in experienced reality. It then proposed a new metaphor to describe the Trinity and how this affects the human quest for identity in a complex universe.Intradisciplinary and/or interdisciplinary implications: This article investigated the question of being human, using the Christian doctrine of the Trinity as a backdrop. This discussion entailed theology, anthropology and the dialogue between science and religion. The implication of this article is a more integrated perspective on the Trinity and anthropology in the science and religion discourse.
Análisis de la dignidad humana. Principio fundamental de la Doctrina Social de la Iglesia
Authors: Carrasco Schlatter Carlos 
Published: March 2023

La sociedad en su evolución va modificando las cosas, el indiscutible paso del tiempo va adheriendo elementos que inevitablemente solo una revisión puede ayudarnos a descubrir. Este trabajo, parte de una tesina, busca analizar el concepto de la Dignidad, atendiendo a la enorme importancia como principio fundamental de la Doctrina Social de la Iglesia.
Un intento de revitalizar el concepto y buscar nuevas líneas de crecimiento ante el reto de dar respuesta en el marco de la sociedad actual.
Pengaruh Quality of Work Life, Perceived Organizational Support dan Self Eficiacy Terhadap Employee Engagement (Studi Kasus: CV. Cakra Entertainment – Sidoarjo)
Authors: Cahyo Putro Nur 
Published: March 2023

Penelitian ini dilakukan demi terciptanya employee engagement antara karyawan dan pihak perusahaan demi menghadapi dinamika globalisasi pada era saat ini. Objek penelitian yang menjadi concern dalam penelitian ini adalah CV. Cakra Entertainment, sebuah perusahaan atau unit usaha yang bergerak pada sektor rent equipment dalam dunia hiburan. Perusahaan ini menyediakan sewa peralatan dan perlengkapan yang dibutuhkan dalam mengadakan sebuah pagelaran hiburan. CV. Cakra Entertainment berdiri pada tahun 2015. Penelitian ini menguji hubungan menggunakan metode Structural Equation Modeling – Partial Least Square (SEM-PLS). Metode ini merupakan solusi lain yang dapat dipakai dalam metode analisis regresi, selain itu berguna untuk mengetahui korelasi antara variabel penelitian dan sejauh mana besaran nilainya variabel independen Quality of Work Life, Perceived Organizational Support dan Self Efficacy mempengaruhi variabel dependen Employee Engagement. Penelitian ini menghasilkan R-Square sebesar 66,3 % yang berarti variabel independen hanya mampu menjelaskan dengan nilai itu, dan nilai sisanya terdapat pada variabel lain di luar dari penelitian. Selain itu diperoleh bahwa quality of work life berpengaruh signifikan dengan nilai 5,047 terhadap employe engagement, variabel perceived Organizational Support berpengaruh signifikan dengan nilai 4,236 terhadap employe engagement sedangkan variabel self efficacy tidak berpengaruh 0,138 terhadap employe engagement. Dengan hasil yang diperoleh diharapkan perusahaan memerhatikan variabel beserta indikatornya yang berpengaruh demi terciptanya employee engagemment pada CV. Cakra Entertainment.
PENGARUH RASIO SOLVABILITAS DAN RASIO PROFITABILITAS TERHADAP PERUBAHAN LABA PADA PERUSAHAAN KONSTRUKSI YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2015-2018
Authors: Rahmiyanti Sev 
Published: March 2023

Tujuan penelitian ini adalah untuk mengetahui pengaruh rasio solvabilitas dan rasio profitabilitas baik secara parsial maupun secara simultan terhadap Perubahan Laba pada perusahaan konstruksi yang terdaftar di Bursa Efek Indonesia. Rasio solvabilitas yang diuji adalah Debt to Assets Ratio dan rasio profitabilitas yang diuji adalah Return On Equity. Populasi dalam penelitian ini adalah 16 perusahaan konstruksi bangunan yang terdaftar di Bursa Efek Indonesia. Pemilihan sampel menggunakan metode purposive sampling. Jumlah sampel tersebut adalah 9 perusahaan konstruksi yang terdaftar di Bursa Efek Indonesia selama periode 2015-2018 dengan jumlah 36 data penelitian. Data yang diperoleh merupakan data sekunder dengan metode dokumentasi. Teknik analisis data dilakukan dengan uji asumsi klasik yang meliputi uji normalitas, uji multikolinieritas, uji autokorelasi dan uji heteroskedastisitas, sedangkan uji hipotesis dilakukan dengan analisis regresi berganda.
Hasil penelitian ini menunjukkan bahwa (1) Terdapat pengaruh positif tidak signifikan Debt to Assets Ratio terhadap Perubahan Laba pada perusahaan konstruksi yang terdaftar di Bursa Efek Indonesia selama periode 2015-2018. (2) Terdapat pengaruh positif signifikan Return On Equity terhadap Perubahan Laba pada perusahaan konstruksi yang terdaftar di Bursa Efek Indonesia selama periode 2015-2018. (3) Terdapat pengaruh positif dan signifikan Debt to Assets Ratio dan Return On Equity terhadap Perubahan Laba pada perusahaan Konstruksi yang terdaftar di Bursa Efek Indonesia selama periode 2015-2018. Berdasarkan analisis uji regresi dapat dilihat nilai adjusted R square sebesar 0,405 menunjukkan bahwa Debt to Assets Ratio dan Return On Equity mampu memberikan pengaruh sebesar 40,5% terhadap Perubahan Laba.

Kata kunci: Perubahan Laba, Debt to Assets Ratio dan Return On Equity.
PENGARUH DISIPLIN KERJA DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN STUDI KASUS PADA BAGIAN SUPIR PT. TRANSLINDO ABADI MAKMUR, JAKARTA
Authors: Erliyani Ita , Setiawan Djodi 
Published: March 2023

ABSTRAK
Tujuan penelitian ini adalah untuk mengetahui seberapa besar pengaruh variabel Disiplin Kerja (X1), variabel Lingkungan Kerja (X2), secara parsial dan bersamasama terhadap Kinerja Karyawan (Y) pada PT Translindo Abadi Makmur, Jakarta. Metode yang digunakan adalah metode kuantitatif dan menganalisis hubungan antara variabel bebas dan terikat. Alat ukur yang digunakan yaitu menggunakan Skala Likert dengan mengambil 30 responden dari populasi yang ada sebagai sampel penelitian. Untuk melakukan metode analisis data yang digunakan dalam penelitian ini adalah dengan menggunakan bantuan perangkat lunak yaitu Partial Lest Square (PLS) atau SmartPLS versi 3.0. dari hasil penelitian nilai R-Square adalah 0,956 atau 95,6%. Maka dapat dikatakan bahwa disiplin kerja dan lingkungan kerja secara bersama-sama mempunyai pengaruh terhadap kinerja karyawan, yaitu sebesar 95,6% dan menyatakan H3 dapat diterima. Sedangkan selebihnya dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini
Kata kunci: Disiplin Kerja, Lingkungan kerja, Kinerja Karyawan.
ABSTRACK
The purpose of this study was to determine how much influence the Work Discipline variable (X1), Work Environment variable (X2), partially and jointly on Employee Performance (Y) at PT Translindo Abadi Makmur, Jakarta. The method used is a quantitative method and analyzes the relationship between independent and dependent variables. The measuring instrument used is a Likert scale by taking 30 respondents from the population as the research sample. To perform the data analysis method used in this study is to use the help of software, namely Partial Lest Square (PLS) or SmartPLS version 3.0. From the research results, the R-Square value is 0.956 or 95.6%. So it can be said that work discipline and work environment together have an influence on employee performance, which is 95.6% and states that H3 is acceptable. Meanwhile, the rest is influenced by other variables not examined in this study.
Keywords: Work Discipline, Work Environment, Employee Performance.
PENGARUH KEBIJAKAN MANAJEMEN KEUANGAN TERHADAP NILAI PERUSAHAAN (Studi Empiris Perusahaan Manufaktur yang Listing di BEI Tahun 2015 – 2021
Authors: Haerani Anggi , Nuraisiah Rohaelis 
Published: March 2023

Di pasar modal, kenaikan dan penurunan harga saham ditentukan oleh banyak faktor,salah satunya adalah informasi akuntansi keuangan. Informasi akuntansi yang lebih luas,sehingga tingkat perusahaan akan meningkat. Beberapa faktor yang termasuk informasiakuntansi keuangan adalah keputusan investasi, keputusan dana, dan keputusan dividen. Tujuandari penelitian ini adalah untuk menganalisis pengaruh keputusan investasi, keputusan dana, dankeputusan dividen terhadap tingkat bunga perusahaan. Populasi penelitian ini adalah seluruh perusahaan manufaktur yang bergabung di BEI dari tahun 2009 sampai dengan tahun 2011. Sampel penelitian ini adalah beberapa perusahaan manufaktur yang bergabung di BEI dari tahun 2015 sampai dengan tahun 2011. Teknikpengambilan sampel menggunakan purposive sampling dan didapatkan sampel 36 perusahaan. Dokumentasi digunakan sebagai teknik pengumpulan data. Teknik analisis yang digunakan adalah double region. Hasil penelitian menunjukkan bahwa : (1) Keputusan Investasi berpengaruh terhadap tingkat pertumbuhan perusahaan. (2) Keputusan dana tidak berpengaruh terhadap laju perusahaan. (3) Keputusan dividen tidak harus berpengaruh terhadap tingkat perusahaan. (4) Keputusan Investasi, Keputusan Dana, dan Keputusan Dividen berpengaruh terhadap Tingkat Perusahaan. Besar pengaruhnya sebesar 48,2%.
The Department of Civil Engineering, UWI St. Augustine: A Historical Note of 1972-2001
Authors: Shrivastava Gyan 
Published: March 2023

This paper is a continuation of a history of the Department of Civil Engineering at The University of the West Indies (UWI) at St. Augustine. It thus extends an account of its formative decade 1961-1971 previously published (in 2013) in The West Indian Journal of Engineering. The three subsequent decades covered herein encompass milestones, and transformations: (a) beginning of graduate level research, (b) commencement of an MSc programme in Construction Engineering and Management, (c) change of name from Civil to ‘Civil and Environmental’ for embracing the heightened awareness of environmental concerns, (d) relocation into a purpose-built building with a floor space of approximately 5,000 m2, (e) construction of new environmental engineering, engineering geology, highway engineering, soil mechanics and structural engineering laboratories, (f) expansion and modernisation of the fluid mechanics laboratory, and (g) introduction of the semester system with its credit-based curriculum and assessment. Besides, there was a fivefold increase in student enrolment, followed by a sharp decline, and an increase in academic staff strength from six to twenty. This period also witnessed a gradual loss of regional diversity of its undergraduate students from a high of approximately 50 % in 1972 to less than 10% in 2001. On the other hand, there was a notable, and opposite, change in gender (female/male) ratio among the students – from less than 10%/90% in 1972 to approximately 50%/50% in 2001. Finally, the accreditation of the department’s degree programmes by the Engineering Council in the United Kingdom (UK), as well as the triennial visit of overseas external examiners, inherited from its inception, were maintained. Keywords:	Civil Engineering; Coastal Engineering; Environmental Engineering; Education; History; University; West Indies
Implementasi Reward dan Punishment dalam Menciptakan Lingkungan Kondusif Belajar Pada Mata Pelajaran Siroh di SDIT Al-Hikmah Depok
Authors: Ramdhani Rahmat , Sayekti Siskha Putri , Rohman Dul , Fahma M. Badran 
Published: March 2023

The purpose of this study was to determine the conducive learning environment for the Siroh subject in grades IV, V and VI at SDIT Al Hikmah Depok through the application of Reward and Punishment. This research is a qualitative research "case study". The research subjects were students in grades IV, V and VI of SDIT Al Hikmah Depok, totaling 78 students. Sources of data come from teachers, data and documents. Data collection techniques are by observation, interviews and documentation. The data validation technique uses triangulation of data sources. Data analysis used descriptive analysis techniques and qualitative analysis techniques. The results of this study indicate that through the application of the Reward and Punishment learning method it can create a conducive learning environment, especially in the Siroh subject. The conclusion of this study is that the application of the Reward and Punishment learning method can create a conducive environment for learning the Siroh subject for grades IV, V and VI SDIT Al Hikmah Depok. The results of the research are: 1) The effectiveness and efficiency of reward and punishment, 2) The teacher can manage the class well through reward and punishment, 3) A conducive environment supports students' comfort. The conclusion of the results of research conducted at SDIT AL-HIKMAH using a case study approach and applying the Reward and Punishment method yielded quite good results. student.
Keywords: reward and punishment, conducive learning environment
Development of Biofertilizer from Locally Sourced Materials
Authors: Yunus Mujahid Umar , Silas Kiman , Yaumi Ali L. , Kwaji Bitrus Highina 
Published: March 2023

The appropriate rationing of NPK is a core problem in biofertilizer production. In this study, a 30-liter bench-scale anaerobic biodigester for biofertilizer production from solid waste was fabricated using galvanized steel sheet. About 4kg of chicken dung, 7.5 kg of wastewater treatment sludge, and 0.5 kg of banana peel are mixed, a total of 12kg, the substrate is then mixed with water in a ratio of 1:1. (w/w) 24 kg of the slurry is fed into the biodigester. The slurry is allowed to stay for 37 days at mesophilic temperature. The pH of the digestion is between 6-7, and the temperature is within the range of 25-34oC. The amount of total solid, moisture content, ash, and volatile matter of the feedstock after digestion decreases by about 31%,47%,67%, and 69%. Moreover, an increase in the amount of nitrogen content from 0.3783% to 0.6420%, phosphorous from 0.1903% to 0.2983%, and potassium from 0.1876% to 0.3153% was also observed. After digestion the biofertilizer produced has an appropriate ratio of 2:1:1. For the kinetic study, the specific growth was found to be 0.0098hr-1. Also, experimental data for microbial growth obtained from the study fitted the Monod model.
Improvement of legal regulation of dividend payments in the Republic of Uzbekistan
Authors: Umarov Bekzod 
Published: March 2023

This article examines the theoretical and practical issues of legal regulation of the payment of dividends in joint-stock companies, various models, and features of the dividend policy, as well as the main directions for improving the legal regulation of decision-making and the payment of dividends by types of shares. In addition, the article analyses the topical problems of legal regulation of the procedure for paying dividends in joint-stock companies and ways to improve them based on national and best practices in foreign countries.