bluuebunny/crossref_metadata_2025_split huggingface dataset:
Informal human rights law-making: How treaty bodies use ‘General Comments’ to develop international law
Authors: Lesch Max , Reiners Nina 
Published: March 2023

AbstractThe United Nations treaty bodies were established to monitor the implementation of human rights by states parties. Through ‘General Comments’ – legally non-binding clarifications of treaty obligations – they have also influenced the development of international human rights law – for example, on the right to life and climate impacts. We address this phenomenon by establishing a twofold argument. First, we argue that General Comments are used by the committees to informally shape international law. They deliberately act as human rights law-makers, knowing that international institutions, organizations and professionals in their network will subsequently refer to such instruments. Second, we argue that treaty bodies not only rely on their network once they have adopted their outcome, but the experts’ personal networks also shape the drafting process of General Comments. We develop and illustrate an analytical framework with two case studies of General Comments on the human right to water and the torture prohibition. The analysis demonstrates the need for external knowledge of both technical and legal aspects of the norms being interpreted. By addressing pressing human rights challenges, expert committees can shape the law in times of stagnation and resist contestation even from powerful states.
Atmospheric Variations in Summertime Column Integrated CO2 on Synoptic Scales Over the U.S.
Authors: Wang Qingyu , Crowell Sean M. R. , Pal Sandip 
Published: March 2023

AbstractPast studies have demonstrated that synoptically active weather systems play an important role in the spatial and temporal variations of atmospheric carbon dioxide (CO2) within and above the planetary boundary layer. For the first time, we investigate the spatial variability of column‐averaged dry‐air mole fractions of () due to the impact of synoptic scale transport using retrievals from the Orbiting Carbon Observatory‐2 (OCO‐2) for 66 summer cold front passage cases over the conterminous U.S. and Mexico from 2015 to 2019. differences across cold fronts in summer were found to be in good agreement with observations obtained from the Atmospheric Carbon and Transport (ACT‐America) field campaign, though with a reduced magnitude due the flat averaging kernel representing fairly uniform vertical sensitivity in the troposphere as opposed to in situ measurements. OCO‐2 observed frontal differences are statistically distinct from north‐south climatological spatial variations on similar spatial‐scales on synoptically benign days, implying that the frontal passages contribute to enhanced spatial contrasts. An exploratory analysis finds no evidence of a linkage between the temperature differences and differences, but a more thorough exploration is left as future work.
Significance of Diapycnal Mixing Within the Atlantic Meridional Overturning Circulation
Authors: Cimoli Laura , Mashayek Ali , Johnson Helen L. , Marshall David P. , Naveira Garabato Alberto C. , Whalen Caitlin B. , Vic Clément , de Lavergne Casimir , Alford Matthew H. , MacKinnon Jennifer A. , Talley Lynne D. 
Published: March 2023

AbstractDiapycnal mixing shapes the distribution of climatically important tracers, such as heat and carbon, as these are carried by dense water masses in the ocean interior. Here, we analyze a suite of observation‐based estimates of diapycnal mixing to assess its role within the Atlantic Meridional Overturning Circulation (AMOC). The rate of water mass transformation in the Atlantic Ocean's interior shows that there is a robust buoyancy increase in the North Atlantic Deep Water (NADW, neutral density γn ≃ 27.6–28.15), with a diapycnal circulation of 0.5–8 Sv between 48°N and 32°S in the Atlantic Ocean. Moreover, tracers within the southward‐flowing NADW may undergo a substantial diapycnal transfer, equivalent to a vertical displacement of hundreds of meters in the vertical. This result, confirmed with a zonally averaged numerical model of the AMOC, indicates that mixing can alter where tracers upwell in the Southern Ocean, ultimately affecting their global pathways and ventilation timescales. These results point to the need for a realistic mixing representation in climate models in order to understand and credibly project the ongoing climate change.
High‐Frequency Receiver Functions With Event S1222a Reveal a Discontinuity in the Martian Shallow Crust
Authors: Shi J. , Plasman M. , Knapmeyer‐Endrun B. , Xu Z. , Kawamura T. , Lognonné P. , McLennan S. M. , Sainton G. , Banerdt W. B. , Panning M. P. , Wang T. 
Published: March 2023

AbstractThe shallow crustal structure of Mars records the evolutionary history of the planet, which is crucial for understanding the early Martian geological environment. Until now, seismic constraints on the Martian crust have come primarily from the receiver functions (RFs). However, analysis of the Mars RFs did not focus on the shallow structure (1–5 km) so far due to the limitation of the signal‐to‐noise ratio at high frequencies for most events. Here, we take advantage of the S1222a and six other marsquakes, which exhibit high signal‐to‐noise ratios, to probe the shallow structure of Mars. We observe a converted S‐wave at approximately 1 s after the direct P‐wave in the high‐frequency P‐wave RFs. This suggests a discontinutity at 2‐km depth between highly fractured and more coherent crustal materials.
Characteristics of Gravity Wave Horizontal Phase Velocity Spectra in the Mesosphere Over the Antarctic Stations, Syowa and Davis
Authors: Kogure Masaru , Nakamura Takuji , Murphy Damian J. , Taylor Michael J. , Zhao Yucheng , Pautet Pierre‐Dominique , Tsutsumi Masaki , Tomikawa Yoshihiro , Ejiri Mitsumu K. , Nishiyama Takanori 
Published: March 2023

AbstractMesospheric gravity‐wave (GW) phase velocity spectra and total powers at two Antarctic stations, Davis and Syowa, were derived using OH airglow data from March to October in 2016. The total powers have similar seasonal variation, that is, maxima in winter at both stations. The average powers at both stations in winter were not significantly different. However, the power at Davis in September was three times smaller than that at Syowa. This lower power at Davis was attributed to GWs with omnidirectional phase velocity. These lower GW activities at Davis could be attributed to a longitudinal variation in wave filtering; a stronger wind at Davis filtered out more GWs than at Syowa. Also, to explore possible sources in the middle atmosphere, we investigated one event, in which GWs with ∼100 ms−1 southeastward phase velocity appeared at Davis on 29 August. The raytracing method was applied, and its result indicated that those GWs with high southeastward phase velocity propagated from ∼45 km altitude or higher over the Southern Ocean. A large residual of the non‐linear balanced equation was found at 50 km on its ray path. GWs, very likely emitted from a tropospheric jet, were also found near the ray path at the termination altitude over the Southern Ocean and possibly appeared saturated between 45 and 50 km. Therefore, the OH imager at Davis probably captured GWs generated by a spontaneous adjustment in the upper stratosphere and/or secondary GWs produced by the breaking of the GWs that have originated from the tropospheric jet.
Revealing the Formation of the Dipole Mode of Eurasian Snow Cover Variability During Late Autumn
Authors: Zhang Taotao , Feng Yingying , Chen Haishan 
Published: March 2023

AbstractA zonal dipole pattern of the interannual variability of Eurasian snow cover during late autumn has attracted growing interest due to its extensive influences on large‐scale atmospheric circulations and climate anomalies, but it remains unknown what influences the formation of this pattern. This study revealed the potential drivers and the related physical processes of the dipole mode of the snow cover variability during 1979–2018. Results showed that the atmospheric circulation anomalies play a crucial role in forming the dipole mode, which could be further attributed to the influences of the atmospheric teleconnection patterns and the variations of sea surface temperature (SST) and sea ice concentration. Specifically, the anomalous circulations related to the teleconnections of the Eastern Atlantic pattern, East Atlantic–Western Russia pattern, and Scandinavian pattern could lead to the anomalies of air temperature and snowfall that directly shape the variability of snow cover. In addition, a dipole structure of the SST anomalies over the North Atlantic exerts an important effect on the snow cover variability through exciting an eastward propagating Rossby wave train prevailing over Eurasia. Moreover, the snow cover variability is closely linked to the sea ice variations over the Barents Sea that can regulate the anomalous circulations over Eurasia by altering the atmospheric dynamic and thermodynamic conditions. These influencing factors jointly account for about 66% of variances in the dipole mode of snow cover variability, suggesting that our findings can substantially improve the understanding of the Eurasian snow cover variations.
Enhancement of Summer Nitrogen Fixation by the Kuroshio Intrusion in the East China Sea and Southern Yellow Sea
Authors: Jiang Zhibing , Zhu Yuanli , Sun Zhenhao , Zhai Hongchang , Zhou Feng , Yan Xiaojun , Zeng Jiangning , Chen Jianfang , Chen Quanzhen 
Published: March 2023

AbstractThe western boundary currents are characterized by abundant diazotrophs including Trichodesmium, which may fuel N2 fixation when they intrude into marginal seas. The Kuroshio, a western boundary current in the North Pacific, flows into the East China Sea (ECS) and southern Yellow Sea (SYS), which transports abundant Trichodesmium and diatom‐diazotroph associations (DDAs). Additionally, low nitrogen:phosphorus (N:P) ratio and relatively abundant dissolved iron have been observed in the offshore ECS because of the Kuroshio intrusion as well as riverine/atmospheric inputs of P and iron. We hypothesized that the intrusion of Kuroshio greatly enhanced N2 fixation in the ECS and SYS. N2 fixation rates (NFRs) were measured using a 15N2 bubble method during summer 2013. The surface and depth‐integrated NFRs in the ECS and SYS were 1.45 nmol N L−1 d−1 and 81.7 μmol N m−2 d−1 on average, respectively, with the highest values of 13.84 nmol N L−1 d−1 and 511.8 μmol N m−2 d−1. We found that NFRs were significantly higher in the ECS oceanic (Kuroshio water) and mesohaline regions (Kuroshio‐affected water) than in the SYS and the ECS low‐salinity and coastal upwelling regions. NFR was significantly positively correlated with the densities of Trichodesmium and DDAs, salinity, and temperature but was negatively with NO3− and N:P ratio. Generalized additive models confirmed that spatial variation in NFR was overwhelmingly contributed by Trichodesmium density. These findings suggested that the Kuroshio intrusion significantly enhanced N2 fixation in the ECS through promoting growth of filamentous diazotrophs and providing appropriate nutrient environment.
Tidal Pumping Controls Dissolved Organic Matter Properties and Outwelling From Mangrove Groundwater to Coastal Water
Authors: Xiao Kai , Zhang Peng , Santos Isaac R. , Wang Jun‐Jian , Li Zhenyang , Wang Xuejing , Wang Ying‐Hui , Lu Meiqing , Zhang Licong , Li Hailong 
Published: March 2023

AbstractDissolved organic matter (DOM) in highly productive intertidal mangroves is an important carbon and nutrient source to the coastal ocean. In highly dynamic mangrove intertidal systems, both tidal pumping or geochemical factors can control DOM characteristics. The influence of groundwater flow on DOM properties and fluxes remains poorly understood. Here, we compared the concentrations, sources, and spectroscopic characteristics of DOM across a recharge‐discharge gradient. We used a three‐dimensional array sampling strategy to reduce spatial biases, groundwater monitoring to quantify tidally driven exchange, and spectrofluoroscopy to quantify DOM fluorescent components. The results showed that tidal hydrology played the key role driving groundwater DOM properties in both horizontal (i.e., from the mangrove to the sea) and vertical directions. Due to the high spatial heterogeneity of dissolved inorganic (DIC) and organic (DOC) carbon concentrations in mangrove groundwater, carbon outwelling showed a high degree of variability at the intertidal scale (54.8–234.8 μmol m−2 d−1 for DIC and 2.5–12.4 μmol m−2 d−1 for DOC). The contribution of terrestrial DOM gradually decreased toward the ocean, but the microbial contributions for recently produced autochthonous DOM increased. Deep groundwater received less terrestrial DOM and experienced anaerobic microbial mineralization, resulting in lower organic carbon than shallow groundwater. Greater variations in spectroscopic characteristics were found in shallow groundwater than in deep groundwater. Overall, tidally driven surface water‐groundwater interactions control the variability in DOM properties and how DOM contributes to carbon budgets and sequestration in mangrove groundwater.
Ethnic inequalities in child oral health behaviours among five- and eight-year-old children from England, Wales and Northern Ireland
Authors: bin Hayyan Faisal M. F. , Heidari Ellie , Bernabé Eduardo 
Published: March 2023

AbstractAim To examine whether there are ethnic inequalities in child oral health behaviours and the role of parental socioeconomic status (SES) in explaining them.Methods Data from 2,186 five- and eight-year-olds of white, Asian, Black and other ethnicity, who participated in the 2013 Children's Dental Health Survey, were analysed. Parents reported their children's toothbrushing and dental attendance. Logistic regression was used to explore ethnic inequalities in child behaviours, adjusting for demographic factors and parental SES.Results Children of Asian ethnicity were less likely to start brushing early in life (odds ratio [OR]: 0.25; 95% confidence interval [CI]: 0.15-0.43), brush regularly (OR: 0.56; 95% CI: 0.32-0.97) and have a check-up last year (OR: 0.28; 95% CI: 0.16-0.49) than those of white ethnicity. Children of Black ethnicity were less likely to have a check-up last year (OR: 0.39; 95% CI 0.17-0.89) than those of white ethnicity. Children of other ethnicity were less likely to start brushing early in life (OR: 0.41; 95% CI: 0.23-0.77) and brush regularly (OR: 0.45; 95% CI: 0.23-0.87) than children of white ethnicity. Inequalities in toothbrushing frequency and regular dental attendance between children of Black and white ethnicity were fully attenuated after adjustment for parental SES.Conclusion There were ethnic inequalities in child toothbrushing and dental visiting, with children of Asian ethnicity being the most affected. Parental SES only explained part of these inequalities.
Metabolomic profiling of overnight peritoneal dialysis effluents predicts the peritoneal equilibration test type
Authors: Kim Hyo Jin , Choo Munki , Kwon Hyuk Nam , Yoo Kyung Don , Kim Yunmi , Tsogbadrakh Bodokhsuren , Kang Eunjeong , Park Sunghyouk , Oh Kook-Hwan 
Published: March 2023

AbstractThis study primarily aimed to evaluate whether peritoneal equilibration test (PET) results can be predicted through the metabolomic analysis of overnight peritoneal dialysis (PD) effluents. From a total of 125 patients, overnight PD effluents on the day of the first PET after PD initiation were analyzed. A modified 4.25% dextrose PET was performed, and the PET type was categorized according to the dialysate-to-plasma creatinine ratio at the 4-h dwell time during the PET as follows: high, high average, low average, or low transporter. Nuclear magnetic resonance (NMR)-based metabolomics was used to analyze the effluents and identify the metabolites. The predictive performances derived from the orthogonal projection to latent structure discriminant analysis (OPLS-DA) modeling of the NMR spectrum were estimated by calculating the area under the curve (AUC) using receiver operating characteristic curve analysis. The OPLS-DA score plot indicated significant metabolite differences between high and low PET types. The relative concentrations of alanine and creatinine were greater in the high transporter type than in the low transporter type. The relative concentrations of glucose and lactate were greater in the low transporter type than in the high transporter type. The AUC of a composite of four metabolites was 0.975 in distinguish between high and low PET types. Measured PET results correlated well with the total NMR metabolic profile of overnight PD effluents.
High expression of PCOLCE gene indicate poor prognosis in patients and are associated with immune infiltration in glioma
Authors: Guo Qingbao , Gao Xin , Li Jingjie , Liu Yukun , Liu Jiayu , Yang Hui , Cui Meng , Zhang Meng , Duan Lian , Ma Xiaodong 
Published: March 2023

AbstractThe procollagen C-protease enhancer (PCOLCE) has been identified to influence tumor growth and metastasis in multiple cancers. However, the relationship between PCOLCE activity and the progression of gliomas remains largely unknown. Glioma RNA-seq data were derived from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas databases for analysis. Kaplan–Meier survival curve, clinical characterization correlation, univariate and multivariate Cox, and receiver operating characteristic curve analyses were performed to assess the prognostic role of PCOLCE. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis were used to determine the functions or pathways associated with PCOLCE. The ESTIMATE and CIBERSORT algorithms, Spearman’s rank correlation analysis, and Tumor Immune Estimation Resource (TIMER) databases were used to explore the relationship between PCOLCE and immune infiltration. Correlation analysis between PCOLCE, related genes, and immune cell markers was conducted using the TIMER database. Immunophenoscore assays were performed to determine differential PCOLCE expression levels in glioma. The sensitivity of multi-drugs were determined to explore potential chemotherapeutic agents in between PCOLCE. Compared to normal brain tissue, PCOLCE expression was increased in glioma and correlated with shorter overall survival (OS). Furthermore, significant differences were observed in the immune scores and immune cell infiltration levels. PCOLCE is positively associated with immune checkpoints and many immune markers. Additionally, PCOLCE expression was higher in gliomas with higher IPS Z-scores in CGGA. High expression of PCOLCE increased sensitivity to multiple chemotherapy agents in CGGA (P < 0.001), and TCGA. These results suggest that PCOLCE significantly influences the prognosis of patients with glioma, can serve as an independent prognostic factor, and is related to tumor immunity. PCOLCE may be a novel immune-related target for treating gliomas. Additionally, analysis of chemosensitivity in gliomas with high PCOLCE expression may provide a promising direction for drug development.
Hypoxia-induced transcriptional differences in African and Asian versus European diabetic cybrids
Authors: Dolinko Andrew H. , Chwa Marilyn , Schneider Kevin , Singh Mithalesh K. , Atilano Shari , Wu Jie , Kenney M. Cristina 
Published: March 2023

AbstractDiabetic retinopathy (DR) is the most common diabetic microvascular complication and cause of blindness in adults under the age of 65. Our results suggest that, when comparing transcriptomes of cultures grown in hypoxic conditions versus room-air, cybrids containing mitochondria from African and Asian diabetic subjects ([Afr + Asi]/DM) have some uniquely different transcriptome profiles compared to European/diabetic (Euro/DM) cybrids (e.g., fatty acid metabolism: EnrichR rank 10 in [Afr + Asi]/DM, rank 85 in Euro/DM; Endocytosis: rank 25 in [Afr + Asi]/DM, rank 5 in Euro/DM; Ubiquitin Mediated Proteolysis: rank 34 in [Afr + Asi]/DM, rank 7 in Euro/DM). As determined by both RNA-seq and qRT-PCR results, transcription of the gene encoding oleoyl-ACP hydrolase (OLAH) was significantly increased in [Afr + Asi]/DM cybrids compared to Euro/DM cybrids in hypoxic conditions. Additionally, our results show that in hypoxic conditions, Euro/DM cybrids and [Afr + Asi]/DM cybrids show similar decreases in ROS production. All cybrids showed decreased ZO1-minus protein levels, but their phagocytic functions were not significantly altered in hypoxic conditions. In conclusion, our findings suggest that the "molecular memory" imparted by [Afr + Asi]/DM mtDNA may act through one of the molecular pathways seen in transcriptome analysis, such as fatty acid metabolism, without significantly changing essential RPE functions.
Noble metal catalyst detection in rocks using machine-learning: The future to low-cost, green energy materials?
Authors: Ifandi Elena , Lai Daphne Teck Ching , Kalaitzidis Stavros , Abu Bakar Muhammad Saifullah , Grammatikopoulos Tassos , Lai Chun-Kit , Tsikouras Basilios 
Published: March 2023

AbstractCarbon capture and catalytic conversion to methane is promising for carbon–neutral energy production. Precious metals catalysts are highly efficient; yet they have several significant drawbacks including high cost, scarcity, environmental impact from the mining and intense processing requirements. Previous experimental studies and the current analytical work show that refractory grade chromitites (chromium rich rocks with Al2O3 > 20% and Cr2O3 + Al2O3 > 60%) with certain noble metal concentrations (i.e., Ir: 17–45 ppb, Ru: 73–178 ppb) catalyse Sabatier reactions and produce abiotic methane; a process which has not been investigated at the industrial scale. Thus, a natural source (chromitites) hosting noble metals might be used instead of concentrating noble metals for catalysis. Stochastic machine-learning algorithms show that among the various phases, the noble metal alloys are natural methanation catalysts. Such alloys form when pre-existing platinum group minerals (PGM) are chemically destructed. Chemical destruction of existing PGM results to mass loss forming locally a nano-porous surface. The chromium-rich spinel phases, hosting the PGM inclusions, are subsequently a second-tier support. The current work is the first multi-disciplinary research showing that noble metal alloys within chromium-rich rocks are double-supported, Sabatier catalysts. Thus, such sources could be a promising material in the search of low-cost, sustainable materials for green energy production.