bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of different surgical treatments for stage II progressive collapsing foot deformity deformity-A Finite element analysis
Authors: Chen Fanglin , Yuan Chengjie , Liang Mian , Xie You , Le Guoping , yang Chengzhi , Chen Renqiang , Chen Kenian , Xu Jian 
Published: July 2023

Abstract
Background: This study analyzed the advantages and disadvantages of different procedures for stage IIA progressive collapsing foot deformity (PCFD) through three-dimensional finite element models.
Methods: Medial column fusion (MCF), medializing calcaneal osteotomy (MCO), lateral column lengthening (LCL), and subtalar joint arthroereisis (SJA) operations were simulated. The maximum pressure on plantar soft tissue, medial column bone, and medial ligaments was compared before and after simulated single-foot weight loading.
Results: The maximum plantar stress of PCFD decreased with MCO and SJA but increased with MCF and LCL. MCF and LCL failed to significantly reduce the stress on the medial column fragments, thereby increasing their stress. Both MCO and SJA relieved medial plantar stress. MCF had no significant effect on stress relief of the medial ligament. MCO, LCL, and SJA were all shown to reduce the pressure on the medial plantar ligament, with LCL having the most obvious effect. All four procedures corrected the arch deformity; however, MCF was not as effective as the other methods. SJA is the best method for restoring arch height and correcting arch deformities. For stage IIA PCFD, isolated MCF failed to reduce pressure on the medial column; however, isolated MCO significantly reduced the pressure on the medial plantar and ligamentous soft tissues while restoring the foot’s arch and correcting the hindfoot valgus.
Conclusion:SJA with type II sinus tarsi implant effectively transferred pressure from the medial plantar tract to the lateral side and restored the arch. Isolated LCL was not found suitable for stage IIA PCFD.
Nomogram development and evaluation for resectable colorectal cancer based on preoperative hemoglobin levels and lymphocyte to monocyte ratio：a retrospective cohort study
Authors: Zhou Jie , Tian Mengjie , Zhang Xiangchen , Xiong Lingyi , Xu Hongli , Yin Zhucheng , Wu Fengyang , Hu Junjie , Liang Xinjun , Wei Shaozhong 
Published: July 2023

Abstract
Background: The impact of lymphocyte to monocyte ratio (LMR) and hemoglobin (Hb) level on the prognosis of solid tumors and hematological malignancies was reported. Therefore, we sought to investigate the prognostic value of LMR-Hb based biomarker in resectable colorectal cancer (CRC).
Methods: Clinical data from 700 CRC patients received radical surgery at Hubei Cancer Hospital from 2013 to 2016 were retrospectively analyzed. To evaluate the connection between clinical outcomes and elements regarding demographics, pathological and laboratory index, we conducted Multivariate Cox regression. A novel nomogram was developed, and its performance was evaluated by its discrimination, calibration, and clinical usefulness.
Results: Kaplan-Meier method demonstrated that poorer overall survival (OS) and disease-free survival (DFS) was associated with higher Hb-LMR Score (P < 0.0001). Multivariate Cox regression illustrated that age at surgery greater than or equal to 65 years, female, the rate of lymph nodes metastasis reaching 0.077 or more, invasion of circumferential resection margin, TNM staging in III-IV, and Hb-LMR score of 2 were independent risk factors for poor OS or DFS. The area under the time-dependent receiver operating characteristic curve, the calibration curve along with decision curve analysis were performed and revealed that the nomogram was excellent in discrimination, calibration and efficacy. The concordance index illustrated that the nomogram has more accurate predictive ability for OS and DFS than TNM stage alone.
Conclusion: Based on preoperative Hb and LMR, we successfully developed a novel and easily accessible prognostic score which had a good performance in predicting clinical outcomes in CRC patients.
Skeletal Expansion Via Craniofacial Distraction Osteogenesis Technique In Syndromic Craniosynostosis: Impact On Ophthalmic Parameters
Authors: Lim Chin Kai , Khaliddin Nurliza , Hassan Muhammad Kamil , Hariri Firdaus 
Published: July 2023

Abstract
Background
This study aims to compare the changes in ophthalmic parameters among syndromic craniosynostosis patients who underwent craniofacial skeletal expansion procedures via distraction osteogenesis (DO).
Method
A retrospective study was conducted involving syndromic craniosynostosis patients who underwent surgical expansion via the DO technique from the year 2012 to March 2022. Changes in six parameters which consist of visual acuity, refractive error, optic disc health, intraocular pressure, degree of proptosis and orbital volume were measured objectively pre and post-surgery. For categorical parameters, the Chi-square cross-tab test was done. Paired sample T-test was used for normally distributed variables. Wilcoxon signed-rank test was used for non-normally distributed data.
Results
Visual impairment was present in 21.4% of eyes before surgery and increased to 28.5% post-surgery. Three patients had changes of refractive error post-surgery with one developed hypermetropia, another developed anisometropia and the last had improvement to no refractive error. Two patients had optic disc swelling which was resolved post-surgery. Intraocular pressure changes were inconsistent post-surgery. All patients achieved a significant reduction in the degree of proptosis post-surgery. Orbital volume calculation using computed tomography (CT) scans shows a significant increase in volume post-surgery for all patients.
Conclusion
Our study shows a significant increase in orbital volume post-surgery with a reduction in the degree of proptosis. Optic disc and nerve health improved after the surgery. Changes in terms of visual acuity, refractive error and IOP were inconsistent after the surgical intervention.
Research on Enterprise Financial Risk Warning Based on AutoEncoder-ConvNeXt
Authors: He Yi , Liu Hongjiu , Hu Yanrong , Liu Qingyang 
Published: July 2023

Abstract
This study combines the AutoEncoder and ConvNeXt models to conduct financial risk warning research on 167 Chinese agro-forestry related enterprises. Firstly, a set of 52 indicators was determined by similarity calculation to further discuss the classification method of financial risk. The CRITIC method, combined with grey correlation analysis, fuzzy comprehensive evaluation, and TOPSIS method, was used to score the financial risk of agro-forestry enterprises. Based on this, a self-organizing mapping network was used to classify the financial risk level, and finally, the AutoEncoder-ConvNeXt model was used to predict the financial risk of enterprises. Compared with other models such as ResNet50 and original ConvNeXt, the prediction accuracy of the AutoEncoder-ConvNeXt model was higher at 87.11%, making it better suited for predicting the financial risks of listed companies.
Nicotinamide Mononucleotide Versus Nicotinamide Riboside in The Protective Effects of Cisplatin-induced DNA Damage in HeLa Cells
Authors: Qiu Shuting , Zhang Yunheng , Shao Shihan , Zhang Yingying , Yin Jie , Xu Xianrong , Yang Lei , Hong Yu , Yang Jun , Tan Xiaohua , Di Chunhong 
Published: July 2023

Abstract
Background Previous studies have shown that the nicotinamide adenine dinucleotide (NAD+) precursors, nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), protected against endogenously or exogenously induced DNA damage, however, whether the two compounds have the same or different efficacy against DNA damage is not clear. In the current study, we systematically compared the effects of NMN and NR on cisplatin-induced DNA damage in HeLa cells. Methods The viability of cisplatin treated HeLa cells with NMN or NR were tested by Trypan blue staining. NMN and NR were added in cells before or after exposed to cisplatin, respectively. Briefly, HeLa cells were pretreated with series doses of NMN or NR (0、0.625、1.25、2.5、5 and 10 mM) for 12 h, and then challenged with 10 µM of cisplatin for the following 12 h; or, HeLa cells were treated by 10 µM of cispaltin for 12 h, and then cultured in medium with 10mM NMN or NR, the cells were harvested at 0, 8, 16, 24 and 32 h later. The DNA damage were assessed by immunofluorescent against phosphor-H2AX (γH2AX) and alkaline comet assay. The intracellular nicotinamide adenine dinucleotide (NAD+) and reactive oxygen species (ROS) were determined by according kit. Results Both NMN and NR could rescued cisplatin-induced cell death in a dose-dependent manner comparably. NMN and NR pretreatment decreased γH2AX levels and shortened comet tail length in a dose-dependent manner, while NR pretreatment exhibiting stronger protective effects than NMN. Although the post-cisplatin administration of NMN and NR also exhibited a protective effect against DNA damage, there were no significant differences between the two compounds. In addition, both NMN and NR can reverse the cisplatin-induced decrease of NAD+ and the generation of ROS, also with no significant difference between them. Conclusion NR is more effective than NMN in maintaining DNA integrity in cisplatin-treated cells.
Mix-net: A Dual-Branch Lightweight Semantic Segmentation Network Based on MRF
Authors: Tan Jingbin , Zhao Xujun , Cai Jianghui , Yang Haifeng , Su Huijuan 
Published: July 2023

Abstract
To enable image segmentation tasks to go beyond microcomputers and similar devices and better adapt to the limited computing and storage capabilities of mobile devices, we have proposed a lightweight semantic segmentation network called Mix-net. Firstly, we designed a Mix Convolution (MC) module for feature extraction and recovery, which significantly reduces the number of parameters in the model while maintaining accuracy. Secondly, to enhance the edge details of various semantics in the images, we simultaneously train two network models. One model focuses on learning the main body details of the images, while the other model is specifically designed for segmentation tasks and is more dedicated to capturing the edges of different semantics. Thirdly, we designed a novel activation function called Mix Rectified Function (MRF), which effectively enhances the accuracy of segmentation tasks and is more suitable for lightweight image segmentation tasks. Additionally, we have employed Group Normalization (GN) to complement MRF for normalization and activation operations, enabling higher accuracy for small-batch segmentation tasks. Finally, our proposed network retains skip-connection structures and incorporates channel shuffling and attention modules to enhance accuracy. We have conducted comparative experiments on the Cityscapes dataset, where Mix-net achieved an Mean Intersection over Union (MIoU) of 81.1% and a smaller model size, utilizing only 1.47M Parameters and 9.93G Floating Point Operations (FLOPs) on a single NVIDIA GeForce RTX3060 graphics card.
Study of a formaldehyde sensor based on cellulose nanocrystals
Authors: Lin Tao , Wang Le , Wei Xiaoyao , Li Jie , Yin Xuefeng 
Published: July 2023

Abstract
Since formaldehyde poses a major threat to human health, it is critical to perform convenient, rapid, and specific formaldehyde detection. Owing to their interesting optical features, iridescent films consisting of chiral nematic liquid crystal phases of cellulose nanocrystals (CNC) have attracted the attention of researchers. As a result, the widebandgap n-type semiconductor SnO2 and CNC, which have stable and outstanding gas-sensitive features as well as high optoelectronic performance, were combined to create biomass-derived chiral nematic composite films. Therefore, a biomass-derived chiral nematic composite film was prepared by combining the wide-band-gap n - type semiconductor SnO2 with stable, excellent gas-sensing characteristics and optoelectronic properties with CNC. Formaldehyde can be integrated into the nematic layer of CNC films and the formaldehyde gas is detected on the CNC. The formed composite film shows yellow, green, and purple structural colors for different formaldehyde concentrations, realizing the recognition by the naked eye of formaldehyde. This produces a red shift in the reflected wavelength and an effective chromaticity jump. This hybrid thin film is expected to advance a new gas-sensing system for rapid and efficient in situ qualitative investigations.
Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats
Authors: Jackson Thomas W. , House John S. , Henriquez Andres R. , Schladweiler Mette C. , Jackson Kimberly MP , Fisher Anna A. , Snow Sam J. , Alewel Devin I. , Motsinger-Reif Allison , Kodavanti Urmila P. 
Published: July 2023

Abstract
Air pollutant exposures have been linked to systemic disease; however, the underlying mechanisms between responses of the target tissue and systemic effects are poorly understood. A prototypic inducer of stress, ozone causes respiratory and systemic multiorgan effects through activation of a neuroendocrine stress response. The goal of this study was to assess transcriptomic signatures of multiple tissues and serum metabolomics to understand how neuroendocrine and adrenal-derived stress hormones contribute to multiorgan health outcomes. Male Wistar Kyoto rats (12–13 weeks old) were exposed to filtered air or 0.8 ppm ozone for 4-hours, and blood/tissues were collected immediately post-exposure. Each tissue had distinct expression profiles at baseline. Ozone changed 1,640 genes in lung, 274 in hypothalamus, 2,516 in adrenals, 1,333 in liver, 1,242 in adipose, and 5,102 in muscle (adjusted p-value < .1, absolute fold-change > 50%). Serum metabolomic analysis identified 863 metabolites, of which 447 were significantly altered in ozone-exposed rats (adjusted p-value < .1, absolute fold change > 20%). A total of 6 genes were differentially expressed in all 6 tissues. Glucocorticoid signaling, hypoxia, and GPCR signaling were commonly changed, but ozone induced tissue-specific changes in oxidative stress, immune processes, and metabolic pathways. Genes upregulated by TNF-mediated NFkB signaling were differentially expressed in all ozone-exposed tissues, but those defining inflammatory response were tissue-specific. Upstream predictor analysis identified common mediators of effects including glucocorticoids, although the specific genes responsible for these predictors varied by tissue. Metabolomic analysis showed major changes in lipids, amino acids, and metabolites linked to the gut microbiome, concordant with transcriptional changes identified through pathway analysis within liver, muscle, and adipose tissues. The distribution of receptors and transcriptional mechanisms underlying the ozone-induced stress response are tissue-specific and involve induction of unique gene networks and metabolic phenotypes, but the shared initiating triggers converge into shared pathway-level responses. This multi-tissue transcriptomic analysis, combined with circulating metabolomic assessment, allows characterization of the systemic inhaled pollutant-induced stress response.
Establishing a cellular model for drug screening targeting TRPV4
Authors: Zheng Kai , Hu Jiang , Liu Xueying , Xing Wenzhu , Hong Qiyuan , Hu Cheng , Hao Feng 
Published: July 2023

Abstract
Transient receptor potential cation channel subfamily V (TRPV4) is a widely expressed multimodal gated ion channel that transports Ca2+ intracellularly upon opening and plays an important role in many physiological and pathological processes. However, existing TRPV4 channel regulators lack specificity and are ineffective, and available screening methods are not suitable for high-throughput screening of regulators. Therefore, in this study, we developed a cellular model and method for high-throughput drug screening targeting TRPV4 channels based on a double mutant(YFP-H148Q/I152L) of the yellow fluorescent protein (YFP) and the calcium-activated chloride channel protein 1, Anoctamin 1 (ANO1). The endogenous expression of TRPV4 in Fischer Rat Thyroid (FRT) cells was determined, TRPV4 ion channel function in FRT cells was verified by electrophysiological techniques, and a TRPV4 cell model co-expressing ANO1 and YFP-H148Q/I152L was constructed. The model was verified to sensitively detect changes in intracellular Ca2+ concentration using membrane clamp experiments and fluorescence quenching kinetics, and the function of the TRPV4 cell model was examined under different temperatures and concentrations of TRPV4 regulators. The model was evaluated to perform well in high-throughput screening.
Mannan and anti-CD40 antibody decorated and tumor antigen, CpG and Poly I:C encapsulated poly lactic-co- glycolic acid (PLGA) nanoparticles loaded dendritic cells induced type I immune responses against prostate cancer ex vivo
Authors: Ziamiavaghi Negin , Delirezh Nowruz , Sheikhzadeh Sanaz 
Published: July 2023

Abstract
Purpose
Cancer vaccines that stimulate the immune system to detect tumor-related antigens and trigger a T cell response have shown remarkable success in prostate cancer immunotherapy. In this study, we used PLGA nanoparticles and a carrier to deliver TCL, CPG-ODN, and Poly I:C to dendritic cells. We engineered the surface of the nanoparticles with mannan and anti-CD40 antibodies to specialize TCL delivery to dendric cells. We estimated different molecules and adjuvants' effects on DCs and T cell activation.
Method
In this study, Poly lactic-co-glycolic acid (PLGA) nanoparticles encapsulated with LNCaP cell line tumor antigens as well as Polyinosinic: polycytidylic acid (Poly: IC) and CpG-ODN as adjuvants. Mannan (MN) and Anti-CD40 antibody were then attached to the surface of PLGA nanoparticles. Monocyte-derived dendritic cells were generated, and on day 4, tumor cell lysate (TCL) and 8 different groups of nanoparticles were added to DCs to stimulate T lymphocytes and measure T cell response in vitro.
Result
Our results showed that using TCL, CpG-ODN, and Poly I:C encapsulated in nanoparticles and decorating the surface of nanoparticles with Mannan and anti-CD40 can induce maturation of dendritic cells and stimulate strong antitumor immune responses as well.
Conclusion
Therefore, combining TCL and adjuvants within nanoparticles and decorating them with Mannan and anti-CD40 enhances antitumor immune responses and can be considered an effective treatment strategy in prostate cancer.
A case report about polycythemia vera and a pregnant woman
Authors: Ma Shuxin , Luo Xia 
Published: July 2023

Abstract
Background: Polycythemia vera (PV), belonging to the myeloproliferative disorder, refers to the apparent overproduction of red blood cells. This pathological change culminates in blood hyperviscosity, which causing pregnant women with high risk of thrombosis. In this study, we introduced a rare case about a pregnant woman with PV in China.
Case summary: In this case report, we summarized the process of diagnosis and treatment about the pregnant woman with previously diagnosed PV during her gestation time. The first onset of this disease was in her twenty-second. She was supplied with hydroxyurea and interferon and got symptoms relieve. But she didn’t undergo regular treatment after that. She was hospitalized during gestation in her thirty-first, treated with regular administration of phlebotomy, aspirin (100mg), and low molecular weight heparin (LMWH). Finally, the patient delivered a healthy newborn after the cesarean.
Conclusion: Early diagnosis and intervention can effectively prevent pregnancy complications. Flexible control of hematocrit levels combined with anticoagulation contributes to improving pregnancy outcomes.
Diversity and Equity in Accounting Education during COVID-19: Insights from Colombia
Authors: Casa Nova Silvia Pereira de Castro , Patiño-Jacinto Ruth Alejandra , Macias Hugo A. 
Published: July 2023

ABSTRACT
This paper aims to open a window into diversity and inequity issues unveiled by COVID-19 in accounting education in a context of social and political unrest. Following interviews and autoethnographic written reports, a survey of Colombian accounting professors was examined and complemented by a student survey. The study drew on the concepts of conscientização and dialogic pedagogy, proposed by Brazilian social scientist Paulo Freire. The findings showed that the pandemic enabled students and faculty to move from a magical to a critical stage of conscientização (critical consciousness). The pandemic led them to reflect on their context, question the role of accounting, and advance their liberation from oppressive positions. We ended our research with the claim a student posted on their profile: “How hard it is to study while they are killing my people!” Future studies may extend the scope of research to other periods and geographic contexts.
Disclosure and Investor Inattention: Theory and Evidence
Authors: Bertomeu Jeremy , Hu Peicong , Liu Yibin 
Published: July 2023

ABSTRACT
Investors have a finite capacity to organize all information they receive from financial disclosures. Under rational inattention, we show that investor processing capacity affects the probability of disclosure. Our main result is that the likelihood of disclosure is inverse-U shaped in investor attention. For low levels of attention, more attention facilitates communication and increases disclosure; for high levels of attention, more attention better identifies, and therefore deters, unfavorable voluntary disclosures. We provide empirical evidence that the relationship between investor attention and management forecast follows the predictions of the theory, using institutional ownership as a proxy for investor attention as well as exogenous shocks to fund manager distraction.
JEL Classifications: D83; G14; M4.
Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling
Authors: Sohn Paul , McLaughlin Madeline R. , Krishnan Preethi , Wu Wenting , Slak Rupnik Marjan , Takasu Akira , Senda Toshiya , Lee Chih-Chun , Kono Tatsuyoshi , Evans-Molina Carmella 
Published: July 2023

Altered endoplasmic reticulum (ER) Ca2+ signaling has been linked with β-cell dysfunction and diabetes development. Store-operated Ca2+ entry replenishes ER Ca2+ through reversible gating of plasma membrane Ca2+ channels by the ER Ca2+ sensor, stromal interaction molecule 1 (STIM1). For characterization of the in vivo impact of STIM1 loss, mice with β-cell–specific STIM1 deletion (STIM1Δβ mice) were generated and challenged with high-fat diet. Interestingly, β-cell dysfunction was observed in female, but not male, mice. Female STIM1Δβ mice displayed reductions in β-cell mass, a concomitant increase in α-cell mass, and reduced expression of markers of β-cell maturity, including MafA and UCN3. Consistent with these findings, STIM1 expression was inversely correlated with HbA1c levels in islets from female, but not male, human organ donors. Mechanistic assays demonstrated that the sexually dimorphic phenotype observed in STIM1Δβ mice was due, in part, to loss of signaling through the noncanonical 17-β estradiol receptor (GPER1), as GPER1 knockdown and inhibition led to a similar loss of expression of β-cell maturity genes in INS-1 cells. Together, these data suggest that STIM1 orchestrates pancreatic β-cell function and identity through GPER1-mediated estradiol signaling.

Article Highlights
Store-operated Ca2+ entry replenishes endoplasmic reticulum (ER) Ca2+ through reversible gating of plasma membrane Ca2+ channels by the ER Ca2+ sensor, stromal interaction molecule 1 (STIM1). β-Cell–specific deletion of STIM1 results in a sexually dimorphic phenotype, with β-cell dysfunction and loss of identity in female but not male mice. Expression of the noncanonical 17-β estradiol receptor (GPER1) is decreased in islets of female STIM1Δβ mice, and modulation of GPER1 levels leads to alterations in expression of β-cell maturity genes in INS-1 cells.