bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individually Tailored Modular “Egg” Hydrogels Capable of Spatiotemporally Controlled Drug Release for Spinal Cord Injury Repair
Authors: Sun Xinyue , Xiong Tiandi , Yang Keni , Wang Lei , Yang Wen , Zhao Haitao , Gao Xu , You Zhifeng , Zhuang Yan , Chen Yanyan , Dai Jianwu 
Published: July 2023

AbstractControllable drug delivery systems (DDS) can overcome the disadvantages of conventional drug administration processes, such as high dosages or repeated administration. Herein, a smart DDS collagen hydrogel is deployed for spinal cord injury (SCI) repair based on modular designing of “egg” nanoparticles (NPs) that ingeniously accomplish controlled drug release via inducing a signaling cascade in response to external and internal stimuli. The “egg” NPs consist of a three‐layered structure: tannic acid/Fe3+/tetradecanol “eggshell,” zeolitic imidazolate framework‐8 (ZIF‐8) “egg white,” and paclitaxel “yolk.” Then NPs served as a crosslinking epicenter, blending with collagen solutions to generate functional hydrogels. Remarkably, the “eggshell” efficiently converts near‐infrared (NIR) irradiation into heat. Subsequently, tetradecanol can be triggered to disintegrate via heat, exposing the structure of ZIF‐8. The Zn‐imidazolium ion coordination bond of the “egg white” is susceptible to cleaving at the acidic SCI site, decomposing the skeleton to release paclitaxel on demand. As expected, the paclitaxel release rate upon NIR irradiation increased up to threefold on the seventh day, which matches endogenous neural stem/progenitor cell migration process. Taken together, the collagen hydrogels facilitate the neurogenesis and motor function recovery, demonstrating a revolutionary strategy for spatiotemporally controlled drug release and providing guidelines for the design of DDS.
Giant Energy Density via Mechanically Tailored Relaxor Ferroelectric Behavior of PZT Thick Film
Authors: Peddigari Mahesh , Wang Bo , Wang Rui , Yoon Woon‐Ha , Jang Jongmoon , Lee Hyunjong , Song Kyung , Hwang Geon‐Tae , Wang Kai , Hou Yuchen , Palneedi Haribabu , Yan Yongke , Choi Han Seung , Wang Jianjun , Talluri Aravindkrishna , Chen Long‐Qing , Priya Shashank , Jeong Dae‐Yong , Ryu Jungho 
Published: July 2023

AbstractRelaxor ferroelectrics (RFEs) are being actively investigated for energy‐storage applications due to their large electric‐field‐induced polarization with slim hysteresis and fast energy charging–discharging capability. Here, a novel nanograin engineering approach based upon high kinetic energy deposition is reported, for mechanically inducing the RFE behavior in a normal ferroelectric Pb(Zr0.52Ti0.48)O3 (PZT), which results in simultaneous enhancement in the dielectric breakdown strength (EDBS) and polarization. Mechanically transformed relaxor thick films with 4 µm thickness exhibit an exceptional EDBS of 540 MV m−1 and reduced hysteresis with large unsaturated polarization (103.6 µC cm−2), resulting in a record high energy‐storage density of 124.1 J cm−3 and a power density of 64.5 MW cm−3. This fundamental advancement is correlated with the generalized nanostructure design that comprises nanocrystalline phases embedded within the amorphous matrix. Microstructure‐tailored ferroelectric behavior overcomes the limitations imposed by traditional compositional design methods and provides a feasible pathway for realization of high‐performance energy‐storage materials.
Photothermal–Magnetic Synergistic Effects in an Electrocatalyst for Efficient Water Splitting under Optical–Magnetic Fields
Authors: Ma Yibing , Zhou Yaya , Wang Chenglong , Gao Bing , Li Jialing , Zhu Miao , Wu Hao , Zhang Chao , Qin Yiqiang 
Published: July 2023

AbstractThe slow oxygen evolution reaction (OER) limits water splitting, and external fields can help improve it. However, the effect of a single external field on the OER is limited and unsatisfactory. Furthermore, the mechanism by which external fields improve the OER is unclear, particularly in the presence of multiple fields. Herein, a strategy is proposed for enhancing the OER activity of a catalyst using the combined effect of an optical–magnetic field, and the mechanism of catalytic activity enhancement is studied. Under the optical–magnetic field, Co3O4 reduces the resistance by increasing the catalyst temperature. Meanwhile, CoFe2O4 further reduces the resistance via the negative magnetoresistance effect, thus decreasing the resistance from 16 to 7.0 Ω. Additionally, CoFe2O4 acts as a spin polarizer, and electron polarization results in a parallel arrangement of oxygen atoms, which increases the kinetics of the OER under the magnetic field. Benefiting from the optical and magnetic response design, Co3O4/CoFe2O4@Ni foam requires an overpotential of 172.4 mV to reach a current density of 10 mA cm−2 under an optical–magnetic field, which is significantly higher than those of recently reported state‐of‐the‐art transition‐metal‐based catalysts.
The Synergy of Electrospinning and Imprinting for Faithful Replication of Fiber Structures
Authors: Sahin Gozde , Vrij Erik , Grant Rhiannon , Giselbrecht Stefan 
Published: July 2023

AbstractElectrospinning is a powerful method to fabricate structures resembling the fibrous texture of the native extracellular matrix. However, the random fiber deposition of the process hinders a faithful reproduction of the fiber mesh morphology on multiple samples, which raises difficulties in experimental designs to systematically test and assess cell response in vitro. A multi‐replication process to precisely reproduce the fiber morphology on different cell culture substrates is developed. The process involves a decoupling of the fiber structure, material, and porosity by combining the key advantages of electrospinning and imprinting. With this, fiber patterns having a diameter between 0.4 and 2.8 µm are replicated on polycarbonate, polystyrene, poly(methyl methacrylate), and cyclic olefin copolymer films. Identical fiber morphology is, then, obtained on porous films having a pore diameter between 2 and 12 µm. Having full control over these parameters allows the multireplication process to engineer well‐characterized cell microenvironments, which can potentially be used to further investigate complex cell–material interactions.
Bi2O3 Layer‐Integrated, Double‐Sided Responsive, Waveband‐Discriminated Perovskite Photodetector for Encrypted Optical Communication
Authors: Liu Shuo , Jiao Shujie , Zhao Yue , Lu Hongliang , Yang Song , Wang Dongbo , Gao Shiyong , Wang Jinzhong , Zhao Liancheng 
Published: July 2023

AbstractEncrypted optical communication is a critical technology in numerous fields, including remote sensing, environmental monitoring, and homeland defense. As a core of wireless interconnect systems, the conventional photodetectors generally receive optical signals from a single direction and fail to distinguish between various wavebands, severely undermining the potential for data transfer and protection. Herein, a Bi2O3 layer‐integrated waveband‐discriminated perovskite photodetector is presented. By rational design of energy band and device architecture, the novel photodetector is self‐powered, double‐sided responsive, and recognizable to the short or long‐wave UV, as well as visible optical signals. Without external bias, the device exhibits a high performance with peak responsivities of 42.1 and 72.3 mA W−1 in frontal and reverse incidence, respectively. Benefiting from these advantages, the photodetector is applicable to optical communication and encryption. In reverse incidence, reversible message delivery is achieved through the conversion and decoding of illumination patterns and binary digits. For a further step, the encrypted processing is fulfilled in frontal incidence. By virtue of the eight irradiation combinations, a secret key containing ten‐bit commands will generate over a billion encryption methods. This work realizes a new mode of communication and encryption that entirely relies on optical signals, offering new insights into wireless communication.
Interfacial Polarization Triggered by Covalent‐Bonded MXene and Black Phosphorus for Enhanced Electrochemical Nitrate to Ammonia Conversion
Authors: Wang Suwen , Song Chengfang , Cai Yanjiang , Li Yongfu , Jiang Peikun , Li Hui , Yu Bing , Ma Tianyi 
Published: July 2023

AbstractMXenes have recently emerged as a new class of electrocatalysts for diverse energy conversion reactions, but they are generally considered to be catalytically inert. Herein, a strategy of interfacial polarization is put forward to improve the catalytic activity of MXenes, with the construction of an interfacial structure consisting of black phosphorus (BP) nanoflakes and Nb2C MXene nanosheets for electrochemical nitrate reduction to ammonia as a proof of concept. The experimental and computational results reveal that a strong interfacial polarization is built between BP nanoflakes and Nb2C nanosheets in the prepared BP/Nb2C composite. The polarization of Nb centers by adjacent BP sites gives rise to the formation of positively centered Nb atoms and BP‐polarized Nb atoms, which synergistically catalyze the cleavage of N–O bonds in HNO2* to form NO*. In addition, the stabilization of monatomic *N by the BP/Nb2C composite is also enhanced compared with BP nanoflakes and Nb2C nanosheets. As a result, both the ammonia yield rate and Faraday efficiency of the BP/Nb2C composite are much higher than that of BP nanoflakes and Nb2C nanosheets. Overall, this work shows the great potential for constructing a strong interfacial polarization to improve the catalytic performance of MXenes‐based electrocatalysts.
Self‐Doped n‐Type Quinoidal Compounds with Good Air Stability and High Electrical Conductivity for Organic Electronics
Authors: Wang Cheng , Yang Yi , Lin Linlin , Xu Bowei , Hou Jianhui , Deng Yunfeng , Geng Yanhou 
Published: July 2023

AbstractAir stable n‐type conductive molecules with high electrical conductivities and excellent device performance have important applications in organic electronics, but their synthesis remains challenging. Herein, we report three self‐doped n‐type conductive molecules, designated QnNs, with a closed‐shell quinoidal backbone and alkyl amino chains of different lengths. The QnNs are self‐doped by intermolecular electron transfer from the amino groups to the quinoidal backbone. This process is ascertained unambiguously by experiments and theoretical calculations. The use of a quinoidal structure effectively improves the self‐doping level, and thus increases the electrical conductivity of self‐doped n‐type conductive molecules achieved by a closed‐shell structure from<10−4 S cm−1 to>0.03 S cm−1. Furthermore, the closed‐shell quinoidal structure results in good air stability of the QnNs, with half‐lives>73 days; and Q4N shows an electrical conductivity of 0.019 S cm−1 even after exposure to air for 120 days. When applying Q6N as the cathode interlayer in organic solar cells (OSCs), an outstanding power conversion efficiency of up to 18.2 % was obtained, which represents one the best results in binary OSCs.
Leader–follower synchronization of networked multi‐agent systems via hybrid protocols
Authors: Shen Yuan , Liu Xinzhi 
Published: July 2023

AbstractThis paper studies the leader–follower synchronization problem of complex‐valued networked multi‐agent systems with time‐delay. A new hybrid protocol including a continuous‐time protocol which is based on the interaction topology of follower agents and a pinning delayed impulsive control protocol is proposed. By employing the Lyapunov functional method in complex domains and the mathematical analysis technique, several delay‐dependent leader–follower synchronization criteria are established that take into account various sizes of delays. Particularly, our result shows that leader–follower synchronization of delayed complex‐valued networked multi‐agent systems can be achieved even if the proposed hybrid protocol is being subject to relatively large impulse delays. A numerical example is provided to illustrate the effectiveness of the theoretical results.
Stages of change: Strategies to promote use of a Pediatric Early Warning System in resource‐limited pediatric oncology centers
Authors: Woo Marisa Cristin , Ferrara Gia , Puerto‐Torres Maria , Gillipelli Srinithya R. , Elish Paul , Muniz‐Talavera Hilmarie , Gonzalez‐Ruiz Alejandra , Armenta Miriam , Barra Camila , Diaz‐Coronado Rosdali , Hernandez Cinthia , Juarez Susana , Loeza José de Jesús , Mendez Alejandra , Montalvo Erika , Peñafiel Eulalia , Pineda Estuardo , Graetz Dylan E. , Kortz Teresa , Agulnik Asya 
Published: July 2023

AbstractBackgroundPediatric Early Warning Systems (PEWS) assist early detection of clinical deterioration in hospitalized children with cancer. Relevant to successful PEWS implementation, the “stages of change” model characterizes stakeholder support for PEWS based on willingness and effort to adopt the new practice.MethodsAt five resource‐limited pediatric oncology centers in Latin America, semi‐structured interviews were conducted with 71 hospital staff involved in PEWS implementation. Purposive sampling was used to select centers requiring variable time to complete PEWS implementation, with low‐barrier centers (3–4 months) and high‐barrier centers (10–11 months). Interviews were conducted in Spanish, professionally transcribed, and translated into English. Thematic content analysis explored “stage of change” with constant comparative analysis across stakeholder types and study sites.ResultsParticipants identified six interventions (training, incentives, participation, evidence, persuasion, and modeling) and two policies (environmental planning and mandates) as effective strategies used by implementation leaders to promote stakeholder progression through stages of change. Key approaches involved presentation of evidence demonstrating PEWS effectiveness, persuasion and incentives addressing specific stakeholder interests, enthusiastic individuals serving as models for others, and policies enforced by hospital directors facilitating habitual PEWS use. Effective engagement targeted hospital directors during early implementation phases to provide programmatic legitimacy for clinical staff.ConclusionThis study identifies strategies to promote adoption and maintained use of PEWS, highlighting the importance of tailoring implementation strategies to the motivations of each stakeholder type. These findings can guide efforts to implement PEWS and other evidence‐based practices that improve childhood cancer outcomes in resource‐limited hospitals.
Epidemiology of cervical cancer in elderly women: Analysis of incidence, treatment, and survival using German registry data
Authors: Neumeyer Sonja , Tanaka Luana Fiengo , Liang Linda A. , Klug Stefanie J. 
Published: July 2023

AbstractBackgroundCervical cancer (CC) screening is generally recommended until age 65. The incidence of CC could be underestimated, particularly in older women, due to a lack of hysterectomy correction. Furthermore, elderly women (≥65 years) are more often diagnosed with late‐stage disease and have worse outcomes than younger patients. This study aims to provide an in‐depth overview of CC in Germany.MethodsIncidence rates of CC (ICD‐10 C53) were determined using data from the German Centre of Cancer Registry data (ZfKD) of six federal state registries. Incidence was corrected by using hysterectomy prevalence values from a real‐world study. The distribution of treatment modalities (surgery, chemotherapy, radiation therapy) was assessed. Relative survival was calculated using the period approach (2011–2015). Survival was stratified by tumor (T) stage and histological type.ResultsIn total, 14,528 CC cases were included, 27.6% of which occurred in elderly women. Cumulative (2001–2015) age‐standardized incidence rates were 12.5 per 100,000 women without hysterectomy correction and 15.5 per 100,000 women after hysterectomy correction (+24% relative change). A lower proportion of elderly women were treated, especially in advanced tumor stages. Younger women (20–64 years) had a higher 5‐year relative survival compared to elderly women: 76.7% versus 46.9%, respectively. Survival was worse with increasing stage and for glandular histological subgroups, particularly among elderly women.ConclusionsCC incidence in elderly women is underestimated and survival is lower compared to younger women in Germany. Due to the high disease burden in elderly women, screening and treatment strategies need to be improved.
Benzimidazol‐1‐yl‐1‐phenylpropanone Analogs as Potent Antimicrobial Agents: Rational Design and Synthesis
Authors: Babbar Ritchu , Makkar Swikriti , Saini Deepika , Rawat Ravi , Vargas‐De‐La‐Cruz Celia , Alenzi Faris Q. , Behl Tapan 
Published: July 2023

AbstractDesigned, synthesized a sequence of novel benzimidazol‐1‐yl‐1‐phenylpropanone hybrids and assessed for in vitro antimicrobial potential counter to several bacterial strains. Computational Methodology was carried out for designing of the target molecules and structures were confirmed by spectroscopic analysis. Amid the 12 integrated derivatives, (3‐(2‐((3‐fluorobenzylidene)amino)‐1H‐benzo[d]imidazol‐1‐yl)‐1‐phenylpropan‐1‐one (6g) and 3‐(2‐((4‐fluorobenzylidene)amino)‐1H‐benzo[d]imidazol‐1‐yl)‐1‐phenylpropan‐1‐one (6k) were found to acquire excellent antibacterial activity against all bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus), whereas derivative 3‐(2‐((2‐fluorobenzylidene)amino)‐1H‐benzo[d]imidazol‐1‐yl)‐1‐phenylpropan‐1‐one (6c), was potent against Escherichia coli, Bacillus subtilis, Staphylococcus aureus and displayed moderate action against P. aeruginosa. Derivatives with NO2 substituent at 3rd and 4th position, 3‐(2‐((3‐nitroobenzylidene)amino)‐1H‐benzo[d]imidazol‐1‐yl)‐1‐phenylpropan‐1‐one (6h) and 3‐(2‐((4‐nitroobenzylidene)amino)‐1H‐benzo[d]imidazol‐1‐yl)‐1‐phenylpropan‐1‐one (6 l) respectively declared good to moderate results against all bacterial strains. Further, 3‐(2‐((3‐chlorobenzylidene)amino)‐1H‐benzo[d]imidazol‐1‐yl)‐1‐phenylpropan‐1‐one (6f) and 3‐(2‐((4‐chlorobenzylidene)amino)‐1H‐benzo[d]imidazol‐1‐yl)‐1‐phenylpropan‐1‐one (6j) were found to be more competent against both fungal strains (C. albicans, A. niger). Serial two‐fold dilution method was used for the entire study and standard drugs utilized were ciprofloxacin and clotrimazole. MIC values (μg/ml) of novel synthesized analogs were reported in comparison to standard drugs for antibacterial and antifungal actions. Molecular docking studies showed that designed molecules dynamically bound with effective area of the receptor (DNA gyrase B, Clotrimazole complex of cytochrome P 45046A1) and in vitro results were in accord with in silico studies.
Acute central retinal artery occlusion with emboli
Authors: Chronopoulos Argyrios , Chatzantonis Georgios , Schutz James Scott , Hattenbach Lars‐Olof 
Published: July 2023

Key Clinical MessageCRAO is an ophthalmic and medical emergency. This case is a reminder that diagnosis and management of CRAO begins with ophthalmologists but immediately thereafter care involves emergency cardiovascular and neurological similar to cerebral stroke.
Point‐of‐care ultrasound aided diagnosis and management of peritoneal parenteral nutrition extravasation in a preterm baby: A case report
Authors: Kowalczyk Alexandra (Ola) , Bhogal Jagmeet , Surak Aimann 
Published: July 2023

Key Clinical MessagePOCUS could identify some of UVC complications at the bedside. It complements the clinical picture and helps narrowing the deferential diagnosis when there is a clinical deterioration.
Vitamin D supplementation leading to hypervitaminosis D in a breastfed infant: A case report
Authors: Twanabasu Sajal , Ghimire Jeevan , Homagain Sushan , Duwadee Prabin , Devkota Susmita , Bhandari Ashish , Sunar Prabhu 
Published: July 2023

Key Clinical MessageBreast milk alone is a poor and inadequate source of vitamin D. Many guidelines suggest supplementation of vitamin D to the newborns to prevent vitamin D deficiency. However, due to practices of outdoor breastfeeding and sunbathing, vitamin D supplementation may not be routinely required in our settings. Overzealous use of vitamin D supplementation and over‐the‐counter prescription may result in hypervitaminosis D.
Neuromyelitis optica spectrum disorder with AQP4‐IgG presenting as area postrema syndrome and progressing to myelitis: A rare case report
Authors: Jagannath Preethi , K Mohammed Suhail , S Shaikh Mohammed Aslam , Kulkarni Ashwin , Prashanth Polasu Sri Satya Sai , Madan Hritik , Anand Ayush 
Published: July 2023

Key Clinical MessageNeuromyelitis optica spectrum disorders can less commonly present with area postrema syndrome progressing to myelitis. Management involves intravenous glucocorticoids, plasma exchange, and preventive immunotherapy.AbstractNeuromyelitis optica spectrum disorders can less commonly present with area postrema syndrome progressing to myelitis. The majority of patients have positive AQP4‐Ab. Diagnosis is based on clinical and imaging findings. These patients can be treated with intravenous glucocorticoids, plasma exchange, and preventive immunotherapy.
Kernohan–Woltman notch phenomenon in patient with subdural hematoma and ipsilateral hemiparesis in Bukavu
Authors: Murhega Roméo Bujiriri , Balemba Ghislain Maheshe , Mudekereza Paterne Safari , Musilimu Sudi , Bisimwa Igega , Munguakonkwa Budema Paul , Mubenga Léon‐Emmanuel 
Published: July 2023

Key Clinical MessageKernohan–Woltman phenomenon is a rare and paradoxical neurological situation in which a transtentorial lesion leads to compression of the contralateral cerebral peduncle responsible for compression of the descending corticospinal fibers with clinical consequence of a motor deficit ipsilateral to the primary lesion. This phenomenon should attract the attention of clinicians in order to avoid unfortunate incidents such as wrong‐side craniotomy in neurosurgical practice. In this work, we report a similar situation.AbstractThe Kernohan–Woltman notch phenomenon is a rare and paradoxical neurological situation in which transtentorial damage is observed leading to compression of the contralateral cerebral peduncle responsible for compression of descending corticospinal fibers with the clinical consequence of a motor deficit ipsilateral to the primary lesion. This phenomenon has been found in several situations including tumors and cerebral hematomas after craniocerebral trauma. In this work, we have reported the case of a 52‐year‐old man with hemiparesis ipsilateral to a large chronic subdural hematoma.
Selective Oxidation of Glucose using Hydrogen Peroxide as an Oxidant: On the Structure Sensitivity of the Apparent Activation Energy
Authors: Reinsdorf Ole , Pellegrin Camille , Schmidt Christoph , Alvear Matias , Eränen Kari , Murzin Dmitry Yu , Salmi Tapio 
Published: July 2023

AbstractThe selective oxidation of glucose to gluconic acid with hydrogen peroxide was studied using different heterogeneous catalysts with alumina (Al2O3) and titanium silicate (TS‐1, TiMWW) as supports and different noble (Au, Pd) and non‐noble metals (Fe, W) as the catalytically active phases. Supported tungsten oxide catalysts showed a moderate selectivity and activity compared to palladium and iron catalysts. The best performance in the selective oxidation of glucose among the studied catalysts was displayed by gold on alumina. For this kind of catalyst, the structure sensitivity in glucose oxidation was explored, revealing a maximum rate shifted to larger gold particle sizes at higher temperatures in comparison with other studies involving activation of molecular oxygen on gold particles. A significant change in the apparent activation energy was established while changing the particle size of gold. These changes of the activation energy were adequately explained by a theoretical model for the cluster size dependence of the apparent activation energy.