bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double Perovskite Oxides Bringing a Revelation in Oxygen Evolution Reaction Electrocatalyst Design
Authors: Banerjee Anwesha , Awasthi Mahendra Kumar , Maji Pramathesh , Pal Manodip , Aziz Sheikh Tarik , Lahiri Goutam K. , Dutta Arnab 
Published: January 2023

AbstractElectrocatalytic water splitting is deliberated as an assuring track to use renewable energy for the production of hydrogen; yet, its industrial application is limited by the anodic oxygen evolution reaction (OER). Perovskite oxide‐based materials have been comprehensively explored as assuring catalysts for OER in alkaline media, with (electro)chemically persuaded alteration of their initially crystalline surface into an amorphous state. This perspective highlights the features of double perovskite electrocatalyst for the oxygen evolution reaction in particular, oxygen‐deficient double‐perovskite with multiple cationic redox sites. The rational reordering of A‐ and B‐sites, along with oxygen vacancy, lead to the generation of an array of novel double perovskite catalysts. A new signifier in stability level is also projected to highlight the relationship between performance and surface stability of OER with perovskite catalyst. This descriptor will offer potential strategies to optimize OER catalytic performance by tuning the surface structure of double‐perovskites.
Green Synthesis of Carbon Nanospheres for Enhanced Electrochemical Sensing of Dopamine
Authors: Lei Peng , Zhou Ying , Sun Xincheng , Dong Chuan , He Yinghe , Liu Yang , Shuang Shaomin 
Published: January 2023

AbstractThe detection of dopamine (DA) has received enormous attention since it is widely recognized as an important neurotransmitter associated with nerve signaling and some diseases. In this work, glucose‐derived carbon nanospheres (CNs) are synthesized by the green hydrothermal approach and are served to modify electrodes for the detection of DA. The CNs were successfully synthesized and were investigated in detail by various characterization technologies. The CNs modified glassy carbon electrode (CNs/GCE) exhibits better electrochemical sensing performance with a wide linear range of 0.05–1600 μM and a low limit of 8.3 nM for determination of DA, as compared with the modified electrodes reported previously. The CNs/GCE was successfully applied to detect DA in human serum samples, which makes it promising for a variety of biomedical applications. More importantly, this work shows a novel green and simple strategy for the development of cost‐effective and high‐performance sensing materials, which provides more opportunities for design of electrochemical sensors with future capabilities of mass production in practical applications.
Polarity‐Evolution Control and Luminescence Regulation in Multiple‐Site Hydrogen‐Bonded Organic Frameworks
Authors: Lv Yuanchao , Liang Jiashuai , Xiong Zhile , Zhang Hao , Li Delin , Yang Xue , Xiang Shengchang , Zhang Zhangjing 
Published: January 2023

AbstractHydrogen‐bonded organic frameworks (HOFs) have shown great potential in separation, sensing and host‐guest chemistry, however, the pre‐design of HOFs remains challenging due to the uncertainty of solvents′ participation in framework formation. Herein, the polarity‐evolution‐controlled framework/luminescence regulation is demonstrated based on multiple‐site hydrogen‐bonded organic frameworks. Several distinct HOFs were prepared by changing bonding modes of building units via the evolution of electrostatic forces induced by various solvent polarities. High‐polar solvents with strong electrostatic attraction to surrounding units showed the tendency to form cage structures, while low‐polar solvents with weak electrostatic attraction only occupy hydrogen‐bond sites, conducive to the channel formation. Furthermore, the conformation of optical building unit can be adjusted by affecting the solvent polarity, generating different luminescence outputs. These results pave the way for the rational design of ideal HOFs with on‐demand framework regulation and luminescence properties.
Near‐Infrared‐Responsive Hydrocarbons Designed by π‐Extension of Indeno[1,2,3,4‐pgra]perylene at the 1,2,12‐Positions
Authors: Kato Masaki , Kim Jinseok , Oh Juwon , Shimizu Daiki , Fukui Norihito , Shinokubo Hiroshi 
Published: January 2023

AbstractThe relationship between the overall electronic structure of π‐conjugated molecules and the arrangement of their constituent elements is of fundamental importance. Establishing rational design guidelines for conjugated hydrocarbons with narrow HOMO‐LUMO gaps is useful to develop near‐infrared (NIR) responsive dyes and redox‐active materials. This study describes the synthesis and properties of three conjugated hydrocarbons, i. e., an indenonaphthoperylene, an indenoterrylene, and a diindenoterrylene. These molecules exhibit NIR absorption despite the absence of significant antiaromaticity and diradical character. Notably, the indenonaphthoperylene exhibits red‐to‐NIR emission in the 620–850 nm region. The indenoterrylene and the diindenoterrylene exhibit NIR absorption tailing to 870 and 940 nm, respectively. Moreover, the effect of the π‐extension of indenoperylene is disclosed in order to propose guidelines for achieving a narrow HOMO‐LUMO gap with negligible antiaromaticity and diradical character.
Multi‐Photon Microscopy
Authors: Sanderson Jeremy 
Published: January 2023

AbstractIn this series of papers on light microscopy imaging, we have covered the fundamentals of microscopy, super‐resolution microscopy, and lightsheet microscopy. This last review covers multi‐photon microscopy with a brief reference to intravital imaging and Brainbow labeling.Multi‐photon microscopy is often referred to as two‐photon microscopy. Indeed, using two‐photon microscopy is by far the most common way of imaging thick tissues; however, it is theoretically possible to use a higher number of photons, and three‐photon microscopy is possible. Therefore, this review is titled “multi‐photon microscopy.” Another term for describing multi‐photon microscopy is “non‐linear” microscopy because fluorescence intensity at the focal spot depends upon the average squared intensity rather than the squared average intensity; hence, non‐linear optics (NLO) is an alternative name for multi‐photon microscopy. It is this non‐linear relationship (or third exponential power in the case of three‐photon excitation) that determines the axial optical sectioning capability of multi‐photon imaging.In this paper, the necessity for two‐photon or multi‐photon imaging is explained, and the method of optical sectioning by multi‐photon microscopy is described. Advice is also given on what fluorescent markers to use and other practical aspects of imaging thick tissues. The technique of Brainbow imaging is discussed. The review concludes with a description of intravital imaging of the mouse. © 2023 Wiley Periodicals LLC.
A 20‐W wideband voltage controlled attenuator for millimeter‐wave applications
Authors: Wang Yuan , Hsu Heng‐Tung , Tsao Yi‐Fan 
Published: January 2023

SummaryIn this paper, we present a distributed voltage controlled attenuator (VCA) featuring an extremely high power handling capability of 20 W. Theoretical analyses have been performed to simultaneously achieve a wideband, low insertion loss, and high attenuation dynamic range performance. Implemented in a commercial 0.25‐μm GaN‐on‐SiC high electron mobility transistor (HEMT) technology, a 1‐ to 25‐GHz VCA was measured to perform a dynamic range of 24 dB, an average insertion loss of 3.4 dB, and an average input 1‐dB compressed power (P1dB) of 43 dBm across the frequencies of interest. To the best of the authors' knowledge, this paper presents the monolithic microwave integrated circuit (MMIC) VCA with the reported highest power handling capability in such compact chip area, while maintaining a nice operating bandwidth and dynamic range.
Reward retraining: A pilot randomized controlled trial of a novel treatment approach for transdiagnostic binge eating
Authors: Juarascio Adrienne S. , Srivastava Paakhi , Manasse Stephanie M. , Wilkinson Megan L. , Felonis Christina R. , Drexler Sarah A. 
Published: January 2023

AbstractObjectiveLow reward response to conventionally rewarding stimuli and high reward response to food (i.e., reward imbalance), has been supported as a maintenance factor for eating disorders characterized by binge eating. The current study was a pilot randomized controlled trial testing a novel treatment approach for binge eating targeting reward imbalance, called Reward Re‐Training (RRT), in comparison to a therapeutic attention control condition (supportive psychotherapy; ST).MethodFifty‐nine participants were randomly assigned to receive either 10 group sessions of RRT or ST via videoconferencing software. Assessments of eating pathology and hypothesized treatment targets were completed at pretreatment, mid‐treatment, and posttreatment, and 3‐month following the end of treatment.ResultsFeasibility and acceptability success benchmarks were achieved. Results found a significant indirect effect of RRT on lower posttreatment global eating pathology through decreases in reward to food from pretreatment to mid‐treatment. No significant differences were observed between groups in terms of change in hypothesized treatment mechanisms or outcomes at posttreatment or 3‐month follow‐up.DiscussionThe current study supports the feasibility and acceptability of RRT, and the preliminary efficacy of both RRT and ST. Further research comparing these approaches to CBT would help to inform who might benefit from non‐CBT based treatment approaches.Public SignificanceThe current pilot study supports the feasibility and acceptability of Reward Re‐Training (RRT) as a treatment for binge eating (BE). RRT produced large, but similar, reductions in overall eating pathology and BE frequency compared to supportive psychotherapy (ST) by 3‐month follow‐up. This study supports further testing of indirect treatments such as RRT for binge eating.
Indirect comparison of SGLT2 inhibitors in patients with established heart failure: evidence based on Bayesian methods
Authors: Chen Hai‐Bin , Yang Yao‐Lin , Meng Rong‐Sen , Liu Xue‐Wei 
Published: January 2023

AbstractAimsHead‐to‐head comparisons among SGLT2 inhibitors treatments in established heart failure remain absent. We conducted a systematic review of dedicated heart failure trials to assess indirectly the composite outcomes and individual clinical endpoints among SGLT2 inhibitor treatments.Methods and resultsWe systematically reviewed randomized controlled trials comparing SGLT2 inhibitors versus placebo in patients with established heart failure. A Bayesian approach to network meta‐analysis was applied. Five trials including four treatment strategies were included in this study. The composite of cardiovascular death or hospitalization for heart failure showed no significant difference in the comparison between dapagliflozin and empagliflozin (OR 1.00, 95% CI 0.66–1.55), dapagliflozin and sotagliflozin (OR 1.54, 95% CI 0.91–2.65), and empagliflozin and sotagliflozin (OR 1.53, 95% CI 0.90–2.69). All‐cause mortality showed no significant difference in the comparison between dapagliflozin and empagliflozin (OR 0.92, 95% CI 0.711–1.18), dapagliflozin and sotagliflozin (OR 1.05, 95% CI 0.68–1.59), and empagliflozin and sotagliflozin (OR 1.14, 95% CI 0.74–1.73). Cardiovascular death showed no significant difference in the comparison between dapagliflozin and empagliflozin (OR 0.94, 95% CI 0.71–1.23), dapagliflozin and sotagliflozin (OR 0.96, 95% CI 0.61–1.55), and empagliflozin and sotagliflozin (OR 1.03, 95% CI 0.64–1.66). Hospitalization for heart failure showed no significant difference in the comparison between dapagliflozin and empagliflozin (OR 1.13, 95% CI 0.64–1.97), dapagliflozin and sotagliflozin (OR 1.56, 95% CI 0.74–3.15), and empagliflozin and sotagliflozin (OR 1.39, 95% CI 0.68–2.78).ConclusionsIn patients with established heart failure, there was no significant difference of the major efficacy outcomes among SGLT2 inhibitor treatments; however, sotagliflozin may be associated with the lowest risk of the composite of cardiovascular death or hospitalization for heart failure, and dapagliflozin may be associated with the lowest risk of all‐cause and cardiovascular mortality.
Comparison of the Estimation Methods from Acute to Chronic Biotic Ligand Model-Based Predicted No-Effect Concentrations for Nickel in Freshwater Species
Authors: Chung Jiwoong , Lee Jong-Hyeon , Hwang Dae-sik , Park Dong-Ho , An Youn-Joo , Yeom Dong-Hyuk , Park Tae-Jin , Choi Jinhee 
Published: January 2023

Abstract
Biotic ligand models (BLMs) and the sensitivities of indigenous species are used to assess the environmental risk considering the bioavailability of metals, such as nickel. However, the BLM-based acute–to–chronic ratio (ACR) is required if the predicted no-effect concentration (PNEC) cannot be derived from the chronic species sensitivity distribution (SSD). The applicability of the ACR approach for estimating BLM-based PNEC for nickel from acute toxicity data was evaluated in the present study. The BLM-based acute SSD for nickel was built using the sensitivities of 21 indigenous species and different taxon-specific BLMs for each taxonomic group. To predict the acute sensitivity of invertebrates, the chronic crustacean nickel BLM with pH effect term, which can account for nickel toxicity at high pH levels, was used. This was used instead of the existing acute BLM for crustacean, which has too narrow a pH range to cover the pH dependency of toxicity. The final BLM-based ACR of nickel, determined within a factor of 1.53 from the species-specific acute and chronic sensitivities of the six species, was more reliable than the typical ACR estimated within a factor of 1.84. A linear relationship (r2 = 0.95) was observed between the PNECs using BLM-based ACR and the PNECs derived from the BLM-based chronic SSD of the European Union Risk Assessment Reports. In conclusion, the BLM-based PNEC for nickel could be derived using the ACR approach, unlike when copper BLM was applied. The BLM-based ACR for nickel is the first result calculated by directly comparing acute and chronic species sensitivities, and will contribute to the application of BLM-based risk assessment in broader ecoregions. Environ Toxicol Chem 2023;42:914–927. © 2023 SETAC
Validation of γ‐radiation and their effect on phenolic compounds, antioxidant activity, and microbial load of fennel (Foeniculum vulgare) seeds and cinnamon (Cinnamomum verum) sticks
Authors: Ahmed Salma M. , Hassan Amro B. 
Published: January 2023

AbstractThe aim of this study was to validate the optimum doses of γ‐radiation and its effect on the antioxidant capacity and microbial load of fennel seeds and cinnamon sticks. Gamma irradiation was applied in different doses 0.0, 2.5, 5.0, 7.5, 10, and 15 kGy. The findings stated that increasing gamma dose significantly (p < .05) increased the total phenolic content of the fennel seeds; however, it was decreased in cinnamon at doses higher than 5 kGy. The total flavonoid content was found higher after treatments at 5 kGy or more minor. After the gamma irradiation treatments, the antioxidant activities were enhanced. The microbial load of these spices was reduced after treatment. Doses more than 10.0 kGy are required to lower the bacterial load in samples, while only 5.0 kGy is sufficient to eliminate fungi growth. The partial least squares regression analysis stated the application of 7.5 kGy and reflects the most valid treatment doses for radiation treatments of fennel seeds and cinnamon sticks. Accordingly, it can be discovered that the γ‐radiation at a dose of 7.5 kGy could be considered a suitable dose for the preservation and decontamination of these spices and also for enhancing its antioxidant capacity. Three spices were subjected to gamma irradiation at different doses. The application of gamma radiation significantly reduces the level of the microbial load in the spices. Gamma irradiation improved the antioxidant capacity of the spices. Gamma irradiation can be applied as an effective preservative method in the food industries.
Unraveling Complex MicroRNA Signaling Pathways with Activity‐Based Protein Profiling to Guide Therapeutic Discovery**
Authors: Evers Parrish , Pezacki John Paul 
Published: January 2023

AbstractmicroRNAs (miRNAs) are important cell factors that can play essential roles, such as regulating transcription factors in embryonic development. Traditionally, microarrays or high‐throughput sequencing of crosslinked protein‐RNA complexes have been applied to deduce direct targets, but these techniques fail to account for biomolecular interactions with functional consequences. Activity‐based protein profiling (ABPP) represents a promising alternative to conventional methods and was applied to the discovery of functional targets of human miRNAs. ABPP identified downregulation of MGLL and LIPC, in response to miR‐185 and miR‐27b, respectively. Hepatitis C virus (HCV) infection was found to be modulated by these indirect downstream effectors. These findings highlight the importance of identifying functional targets in developing novel ways to mimic or inhibit miRNA pathways. This review will focus on miRNA regulation and how ABPP can be used to study these pathways.
Synergistic effects of diazotrophs and arbuscular mycorrhizal fungi on soil biological nitrogen fixation after three decades of fertilization
Authors: Zhou Guopeng , Fan Kunkun , Li Guilong , Gao Songjuan , Chang Danna , Liang Ting , Li Shun , Liang Hai , Zhang Jiudong , Che Zongxian , Cao Weidong 
Published: January 2023

AbstractBiological nitrogen (N) fixation (BNF) via diazotrophs is an important ecological process for the conversion of atmospheric N to biologically available N. Although soil diazotrophs play a dominant role in BNF and arbuscular mycorrhizal fungi (AMF) serve as helpers to favor BNF, the response of soil BNF and diazotrophic communities to different long‐term fertilizations and the role of AMF in diazotrophs‐driven BNF are poorly understood. Herein, a 33‐year fertilization experiment in a wheat–maize intercropping system was conducted to investigate the changes in soil BNF rates, diazotrophic and AMF communities, and their interactions after long‐term representative fertilization (chemical fertilizer, cow manure, wheat straw, and green manure). We found a remarkable increase in soil BNF rates after more than three decades of fertilization compared with nonfertilized soil, and the green manure treatment rendered the highest enhancement. The functionality strengthening was mainly associated with the increase in the absolute abundance of diazotrophs and AMF and the relative abundance of the key ecological cluster of Module #0 (gained from the co‐occurrence network of diazotrophic and AMF species) with dominant diazotrophs such as Skermanella and Azospirillum. Furthermore, although the positive correlations between diazotrophs and AMF were reduced under long‐term organic fertilization regimes, green manuring could reverse the decline within Module #0, and this had a positive relationship with the BNF rate. This study suggests that long‐term fertilization could promote N fixation and select specific groups of N fixers and their helpers in certain areas. Our work provides solid evidence that N fixation and certain groups of diazotrophic and AMF taxa and their interspecies relationship will be largely favored after the fertilized strategy of green manure.
EasyAmplicon: An easy‐to‐use, open‐source, reproducible, and community‐based pipeline for amplicon data analysis in microbiome research
Authors: Liu Yong‐Xin , Chen Lei , Ma Tengfei , Li Xiaofang , Zheng Maosheng , Zhou Xin , Chen Liang , Qian Xubo , Xi Jiao , Lu Hongye , Cao Huiluo , Ma Xiaoya , Bian Bian , Zhang Pengfan , Wu Jiqiu , Gan Ren‐You , Jia Baolei , Sun Linyang , Ju Zhicheng , Gao Yunyun , Wen Tao , Chen Tong 
Published: January 2023

AbstractIt is difficult for beginners to learn and use amplicon analysis software because there are so many software tools to choose from, and all of them need multiple steps of operation. Herein, we provide a cross‐platform, open‐source, and community‐supported analysis pipeline EasyAmplicon. EasyAmplicon has most of the modules needed for an amplicon analysis, including data quality control, merging of paired‐end reads, dereplication, clustering or denoising, chimera detection, generation of feature tables, taxonomic diversity analysis, compositional analysis, biomarker discovery, and publication‐quality visualization. EasyAmplicon includes more than 30 cross‐platform modules and R packages commonly used in the field. All steps of the pipeline are integrated into RStudio, which reduces learning costs, keeps the flexibility of the analysis process, and facilitates personalized analysis. The pipeline is maintained and updated by the authors and editors of WeChat official account “Meta‐genome.” Our team will regularly release the latest tutorials both in Chinese and English, read the feedback from users, and provide help to them in the WeChat account and GitHub. The pipeline can be deployed on various platforms, and the installation time is less than half an hour. On an ordinary laptop, the whole analysis process for dozens of samples can be completed within 3 h. The pipeline is available at GitHub (https://github.com/YongxinLiu/EasyAmplicon) and Gitee (https://gitee.com/YongxinLiu/EasyAmplicon).
Successful treatment of pure red cell aplasia using therapeutic plasma exchange after ABO‐incompatible hematopoietic stem cell transplant
Authors: Vivero Angelica , Peedin Alexis R. , Gao Yuanzheng , Karp Julie Katz 
Published: January 2023

AbstractHematopoietic stem cell transplants (HSCTs) are widely used in the treatment of hematologic malignancies and bone marrow failure syndromes. ABO compatibility is typically of secondary importance, and up to 50% of HSCT are performed in ABO‐incompatible pairings. In the literature, pure red cell aplasia (PRCA) occurs in 1% to 50% of all major/bidirectional ABO‐incompatible stem cell transplants, but treatment of PRCA remains heterogeneous. Here, we report two cases in which patients with transfusion‐dependent PRCA following HSCT were successfully treated with therapeutic plasma exchange (TPE). Case 1: A 52‐year‐old type O‐positive male with acute myeloid leukemia underwent HSCT using apheresis‐derived HSCs from a fully human leukocyte antigen (HLA)‐matched, related type A‐positive male donor. He developed PRCA that was refractory to multiple therapies, so a series of 10 TPE was performed over 3 weeks. Case 2: A 21‐year‐old type A‐positive male with aplastic anemia underwent HSCT using bone marrow‐derived HSCs from a fully HLA‐matched related type B‐positive female donor. He developed PRCA that was refractory to multiple therapies, so a series of 5 TPE was performed over 2 weeks. Case 1: The patient has been transfusion independent since TPE #7, and type A red blood cells (RBCs) were seen on the ABO type after TPE #9. Case 2: The patient has been transfusion independent since after TPE #1, and type B RBCs were seen on the ABO type after TPE #5. TPE was successful in treating two patients with PRCA after ABO‐incompatible HSCT transplants. Isoagglutinin titers decreased below the level of detection for both our patients. Ultimately both patients became transfusion independent and showed evidence of erythroid cell recovery.