bluuebunny/crossref_metadata_2025_split huggingface dataset:
Divisibility of polynomials and degeneracy of integral points
Authors: Rousseau Erwan , Turchet Amos , Wang Julie Tzu-Yueh 
Published: January 2023

AbstractWe prove several statements about arithmetic hyperbolicity of certain blow-up varieties. As a corollary we obtain multiple examples of simply connected quasi-projective varieties that are pseudo-arithmetically hyperbolic. This generalizes results of Corvaja and Zannier obtained in dimension 2 to arbitrary dimension. The key input is an application of the Ru–Vojta’s strategy. We also obtain the analogue results for function fields and Nevanlinna theory with the goal to apply them in a future paper in the context of Campana’s conjectures.
Predictors for response to electronic patient-reported outcomes in routine care in patients with rheumatoid arthritis: a retrospective cohort study
Authors: Wiegel Jimmy , Seppen Bart F. , Nurmohamed Michael T. , ter Wee Marieke M. , Bos Wouter H. 
Published: January 2023

AbstractRoutine collection of electronic patient-reported outcomes (ePROs) can improve clinical care. However, a low response rate may counteract the benefits. To optimize adoption, the aim of this study was to investigate which patient factors and/or timing of the invitation predicted response to ePROs sent prior to consultations in patients with rheumatoid arthritis. We performed a retrospective database study with clinical data collected as part of usual care from the electronic medical records at Reade Amsterdam. The dataset comprised the email invitations to complete the ePRO sent prior to consultation. Multiple patient factors and factors defining the timing of the invitation were investigated if they predicted response to the ePRO through a multivariable logistic generalized estimating equation analysis. In total, 17.070 ePRO invitations were sent to 3194 patients (mean age 60 (SD 14), 74% female), of which 40% was completed. Patients between 55 and 73 years (OR 1.39, 95%CI 1.09–1.77) and with higher social economic status (SES) (OR 1.51, 95%CI 1.22–1.88) had significantly higher odds for completing the ePRO, while patients living in an urban area had lower odds (OR 0.69, 95% CI 0.62–0.76). In year 4 after implementation, the OR was increased to 3.69 (95% CI 2.91–4.90). The implementation of ePROs in daily clinical practice needs improvement since 40% of the ePROs sent prior to consultations were completed. Patients that had higher odds to report the next ePRO were between the age of 55–73, had a higher socio-economic status, and were residents in a rural area. The adoption of reporting the PRO increased over time, but the timing of the prompt did not predict response. Additional research is needed to understand ePRO completion, especially for patients with lower socio-economic status.
Quality of life, health-related quality of life, and associated factors in Huntington’s disease: a systematic review
Authors: van Lonkhuizen Pearl J. C. , Frank Wiebke , Heemskerk Anne-Wil , van Duijn Erik , de Bot Susanne T. , Mühlbäck Alzbeta , Landwehrmeyer G. Bernhard , Chavannes Niels H. , Meijer Eline ,   the HEALTHE-RND consortium, Chavannes Niels H. , de Bot Susanne T. , van Lonkhuizen Pearl J. C , Landwehrmeyer G. Bernhard , Steck Franziska , Klempíř Jiří , Konvalinková Romama , Bezuchová Eva , Dolečková Kristýna , Klempířová Olga , Roth Jan , Ulmanová Olga , Squitieri Ferdinando , Maffi Sabrina , Scaricamazza Eugenia , Migliore Simone , Di Giorgio Chiara , D’Alessio Barbara , Casella Melissa , Hoblyn Jennifer , Thangaramanujam Muthukumaran , Burke Tom , O’Malley Emer , McKenna Stephen , McKenna Ian , Thorpe Jeanette , Coffey Anna , Moldovan Ramona , Foley Peter , Kerr Jacqueline 
Published: January 2023

Abstract
Background
Huntington’s disease (HD) is a genetic, neurodegenerative disease. Due to the progressive nature of HD and the absence of a cure, (health-related) quality of life ((HR)QoL) is an important topic. Several studies have investigated (HR)QoL in HD, yet a clear synthesis of the existing literature is lacking to date. We performed a systematic review on self-reported (HR)QoL, and factors and intervention effects associated with (HR)QoL in premanifest and manifest HD gene expansion carriers (pHDGECs and mHDGECs, respectively).

Methods
PubMed, EMBASE, Web of Science, and PsycINFO were searched systematically from September 17th, 2021, up to August 11th, 2022. Methodological and conceptual quality of the included studies was assessed with two appraisal tools.

Results
30 out of 70 eligible articles were included. mHDGECs experienced lower (HR)QoL compared to pHDGECs and controls, whereas mixed findings were reported when compared to other neurological diseases. Several factors were associated with (HR)QoL that might contribute to lower (HR)QoL in mHDGECs, including depressive symptoms, physical and psychological symptoms, lower functional capacity, lower support, and unmet needs. Multidisciplinary rehabilitation programs and a respiratory muscle training were beneficial for (HR)QoL in mHDGECs.

Discussion
(HR)QoL is experienced differently across the course of the disease. Although (HR)QoL is key for understanding the impact of HD and the effect of symptomatic treatment, there is a need to improve the methodological and conceptual shortcomings that were found in most studies, especially regarding the conceptual clarity when reporting on QoL and HRQoL. Suggestions for strengthening these shortcomings are provided in this review.
Exercise-induced skeletal muscle angiogenesis: impact of age, sex, angiocrines and cellular mediators
Authors: Ross Mark , Kargl Christopher K. , Ferguson Richard , Gavin Timothy P. , Hellsten Ylva 
Published: January 2023

AbstractExercise-induced skeletal muscle angiogenesis is a well-known physiological adaptation that occurs in humans in response to exercise training and can lead to endurance performance benefits, as well as improvements in cardiovascular and skeletal tissue health. An increase in capillary density in skeletal muscle improves diffusive oxygen exchange and waste extraction, and thus greater fatigue resistance, which has application to athletes but also to the general population. Exercise-induced angiogenesis can significantly contribute to improvements in cardiovascular and metabolic health, such as the increase in muscle glucose uptake, important for the prevention of diabetes. Recently, our understanding of the mechanisms by which angiogenesis occurs with exercise has grown substantially. This review will detail the biochemical, cellular and biomechanical signals for exercise-induced skeletal muscle angiogenesis, including recent work on extracellular vesicles and circulating angiogenic cells. In addition, the influence of age, sex, exercise intensity/duration, as well as recent observations with the use of blood flow restricted exercise, will also be discussed in detail. This review will provide academics and practitioners with mechanistic and applied evidence for optimising training interventions to promote physical performance through manipulating capillarisation in skeletal muscle.
Status of the H2020-ROBOMINERS Prototype
Authors: Berner Michael , Sifferlinger Nikolaus August 
Published: January 2023

AbstractThis article presents the current status of the H2020-ROBOMINERS project with focus on the prototype to be developed. The aim of this project is the development of a small-scale mining robot, which will be capable of exploring difficult to access deposits with the ability of selective mining underground, under water, and in slurries. Considerably low weight and power are challenges to be overcome. Environment-friendliness is secured by powering the entire robot water-hydraulically. Core element of the robominer is the main module, in which the locomotion and powering system will be implemented. Additional elements in the robot are sensors for navigation and perception and a production tool to excavate small amounts of material. The locomotion system consists of an Archimedes-screw mechanism, which can be extended in radial direction and used as grippers inside a tunnel to increase its traction capacity. Selective perception tools help the mining robot navigate in harsh terrains and find the ore. A small-scale longitudinal part-face cutter head has been selected as an excavation tool. This cutter head has been tested extensively in the laboratory by performing cutting tests with several rock samples. The performance allows a continuous excavation of soft rock material (successful tests with reasonable excavation rate up to a uniaxial compressive strength of 30 MPa). The mined ore is then slurrified and transported to a processing station. On-board analysis equipment using specializsed sensing systems allows the robot to analyse the slurry composition in real-time. The demonstration and final test of the full-scale prototype are planned in an open-pit oilshale mine. Eventually, the project will serve as a guideline for future mining robots including feasibility studies of different robot designs, potential mine layouts and mining scenarios as well as various excavation tools for different rock conditions.
Implementierung eines Notfallmanagements auf Tunnelbaustellen
Authors: Halwachs Michael , Sifferlinger Nikolaus August 
Published: January 2023

ZusammenfassungDas erhöhte Risiko für Arbeitnehmer und Einsatzorganisationen bei der Bewältigung von Notfällen auf Tunnelbaustellen muss bereits im Risikomanagementprozess für Planung und Umsetzung von Sicherheit und Gesundheitsschutz festgelegt werden. Dazu zählen auch Maßnahmen im Sinne des Notfall- und Krisenmanagements. Um Risiken, die plötzlich und ohne Vorwarnung eintreten können, durch eine rasche Reaktion begrenzen zu können, ist bereits in der Planungsphase die grundsätzliche Konzeption der Zusammenarbeit mit den Einsatzorganisationen abzustimmen. In der Ausführungsphase ist das ausgearbeitete Notfallmanagement durch regelmäßige Begehungen und Übungen mit den Einsatzorganisationen baufortschrittsbezogen abzustimmen und anzupassen. Im Zuge der Übungsnachbereitung müssen die Erkenntnisse evaluiert und dem kontinuierlichen Verbesserungsprozesses des Krisen- und Notfallmanagements zugeführt werden.
Anterior thoracolumbar column reconstruction with the vertebral body stent—safety and efficacy
Authors: Oswald Katharina A. C. , Kälin Joel , Tinner Christian , Deml Moritz C. , Bigdon Sebastian F. , Hoppe Sven , Benneker Lorin M. , Albers Christoph E. 
Published: January 2023

Abstract
Purpose
The aim of this study was to assess safety and efficacy of vertebral body stenting (VBS) by analyzing (1) radiographic outcome, (2) clinical outcome, and (3) perioperative complications in patients with vertebral compression fractures treated with VBS at minimum 6-month follow-up.

Methods
In this retrospective cohort study, 78 patients (61 ± 14 [21–90] years; 67% female) who have received a vertebral body stent due to a traumatic, osteoporotic or metastatic thoracolumbar compression fracture at our hospital between 2012 and 2020 were included. Median follow-up was 0.9 years with a minimum follow-up of 6 months. Radiographic and clinical outcome was analyzed directly, 6 weeks, 12 weeks, 6 months postoperatively, and at last follow-up.

Results
Anterior vertebral body height of all patients improved significantly by mean 6.2 ± 4.8 mm directly postoperatively (p < 0.0001) and remained at 4.3 ± 5.1 mm at last follow-up compared to preoperatively (p < 0.0001). The fracture kyphosis angle of all patients improved significantly by mean 5.8 ± 6.9 degrees directly postoperatively (p < 0.0001) and remained at mean 4.9 ± 6.9 degrees at last follow-up compared to preoperatively (p < 0.0001). The segmental kyphosis angle of all patients improved significantly by mean 7.1 ± 7.6 degrees directly postoperatively (p < 0.0001) and remained at mean 2.8 ± 7.8 degrees at last follow-up compared to preoperatively (p = 0.03). Back pain was ameliorated from a preoperative median Numeric Rating Scale value of 6.5 to 3.0 directly postoperatively and further bettered to 1.0 six months postoperatively (p = 0.0001). Revision surgery was required in one patient after 0.4 years.

Conclusion
Vertebral body stenting is a safe and effective treatment option for osteoporotic, traumatic and metastatic compression fractures.
Effects of the COVID-19 school lockdowns on language and math performance of students in elementary schools: implications for educational practice and reducing inequality
Authors: Oostdam Ron , van Diepen Mieke , Zijlstra Bonne , Fukkink Ruben 
Published: January 2023

AbstractThe current study investigates the effects of the school lockdowns during school years 2019–2020 and 2020–2021 on the achievement scores of primary school students during the COVID-19 pandemic. We analyzed scores for spelling, reading fluency (i.e., decoding speed), reading comprehension, and mathematics from standardized student tracking systems for 5125 students from 26 primary schools in the urban region of The Hague, the Netherlands. Results showed that students in grades 1 through 3 had significant learning delays after the first lockdown. However, results after the second lockdown showed that most students were able to catch up, compared to students from corresponding grades of cohorts before COVID-19. The magnitude of these positive effects was mostly close to the negative effect of the first lockdown. Apparently, during the second lockdown, schools seemed better prepared and able to deliver more effective home schooling and online instruction. The hypothesis that students’ learning from a low SES home environment will suffer most from the school lockdowns could only partly be confirmed. SES effects at the individual level tended to be mitigated by negative effects of SES at the school level, making SES-related differences between schools less profound. The findings of this study offer a broader perspective to evaluate the effects of long-term school closures. Implications for educational practice and issues of inequality between students are discussed.
The Multi-Causal Basis of Developmental Potential Construction
Authors: Vecchi Davide , Santos Gil 
Published: January 2023

AbstractIn this article we analyse the issue of what accounts for developmental potential, i.e., the possible phenotypes a developing organism can manifest during ontogeny. We shall argue in favour of two theses. First, although the developing organism is the unit of development, the complete causal basis for its potential to develop does neither lie entirely in itself as a whole nor in any specific part of itself (such as its genome). Thus, the extra-organismal environment must be counted as one of the three necessary, partial and complementary causal bases for development potential. Secondly, we shall defend a constructivist view of the developmental process. If the genome, the developing organism and the extra-organismal environment are to be counted as proper elements of the causal basis for an organism’s developmental potential, the latter is not a given. Rather, it is the result of an interaction-based construction, a process sometimes generating genuine developmental novelty. We will thus argue for an interactionist multi-causal basis view of developmental potential construction. We contend that our view provides a biologically tenable and metaphysically coherent account of developmental dynamics.
The effect of sampling effort and methodology on range size estimates of poorly-recorded species for IUCN Red List assessments
Authors: Marsh Charles J. , Syfert Mindy M. , Aletrari Elina , Gavish Yoni , Kunin William E. , Brummitt Neil 
Published: January 2023

AbstractGeographic range size is the most commonly implemented criterion of species’ extinction risk used in IUCN Red List assessments, especially for poorly-recorded species. IUCN applies two contrasting range size measures to capture different facets of a species’ distribution: Extent of Occurrence (EOO; Criterion B1) is the area bounding all known occurrences and is a proxy for the spatial autocorrelation of risk, while the Area of Occupancy (AOO; Criterion B2) is the area occupied within this boundary and is related to population size at finer grains. Various methods have been proposed to measure both EOO and AOO. We evaluate the impact of applying four methods for each of Criterion B1 and of B2, as well as key parameter choices, on the Red List status of 227 poorly-recorded neotropical pteridophyte species. Between 2 and 100% of species would be considered threatened depending on methodology. The minimum convex polygon method of estimating EOO was relatively robust to sampling effort for all but the least-recorded species. The IUCN-recommended method for estimating AOO of summing occupied 2 × 2 km grid cells was very strongly correlated with the total number of records. It is likely that only a small fraction of species can be adequately assessed using this method, and we recommend caution applying the method to poorly-recorded species in particular, where models predicting occupancy in unsampled areas (e.g. species distribution models) may provide more accurate assessments. It is vital that methodological information is retained with assessments, and comparisons should only be made between assessments utilising equivalent methods.
Modal-Logical Reconstructions of Thought Experiments
Authors: Mulder R. A. , Muller F.A. 
Published: January 2023

AbstractSorensen (Thought experiments, Oxford University Press, New York, 1992) has provided two modal-logical schemas to reconstruct the logical structure of two types of destructive thought experiments: the Necessity Refuter and the Possibility Refuter. The schemas consist of five propositions which Sorensen claims but does not prove to be inconsistent. We show that the five propositions, as presented by Sorensen, are not inconsistent, but by adding a premise (and a logical truth), we prove that the resulting sextet of premises is inconsistent. Häggqvist (Can J Philos 39(1):55–76, 2009) has provided a different modal-logical schema (Counterfactual Refuter), which is equivalent to four premises, again claimed to be inconsistent. We show that this schema also is not inconsistent, for similar reasons. Again, we add another premise to achieve inconsistency. The conclusion is that all three modal-logical reconstructions of the arguments that accompany thought experiments, two by Sorensen and one by Häggqvist, have now been made rigorously correct. This may inaugurate new avenues to respond to destructive thought experiments.
Setting Physical Activity Goals with a Virtual Coach: Vicarious Experiences, Personalization and Acceptance
Authors: Albers Nele , Hizli Beyza , Scheltinga Bouke L. , Meijer Eline , Brinkman Willem-Paul 
Published: January 2023

AbstractGoal-setting is often used in eHealth applications for behavior change as it motivates and helps to stay focused on a desired outcome. However, for goals to be effective, they need to meet criteria such as being specific, measurable, attainable, relevant and time-bound (SMART). Moreover, people need to be confident to reach their goal. We thus created a goal-setting dialog in which the virtual coach Jody guided people in setting SMART goals. Thereby, Jody provided personalized vicarious experiences by showing examples from other people who reached a goal to increase people’s confidence. These experiences were personalized, as it is helpful to observe a relatable other succeed. Data from an online study with a between-subjects with pre-post measurement design (n=39 participants) provide credible support that personalized experiences are seen as more motivating than generic ones. Motivational factors for participants included information about the goal, path to the goal, and the person who accomplished a goal, as well as the mere fact that a goal was reached. Participants also had a positive attitude toward Jody. We see these results as an indication that people are positive toward using a goal-setting dialog with a virtual coach in eHealth applications for behavior change. Moreover, contrary to hypothesized, our observed data give credible support that participants’ self-efficacy was lower after the dialog than before. These results warrant further research on how such dialogs affect self-efficacy, especially whether these lower post-measurements of self-efficacy are associated with people’s more realistic assessment of their abilities.
Impacts of forest management on stand and landscape-level microclimate heterogeneity of European beech forests
Authors: Menge Joscha H. , Magdon Paul , Wöllauer Stephan , Ehbrecht Martin 
Published: January 2023

Abstract
Context
Forest microclimate influences biodiversity and plays a crucial role in regulating forest ecosystem functions. It is modified by forest management as a result of changes in forest structure due to tree harvesting and thinning.

Objectives
Here, we investigate the impacts of even-aged and uneven-aged forest management on stand- and landscape-level heterogeneity of forest microclimates, in comparison with unmanaged, old-growth European beech forest.

Methods
We combined stand structural and topographical indices derived from airborne laser scanning with climate observations from 23 meteorological stations at permanent forest plots within the Hainich region, Germany. Based on a multiple linear regression model, we spatially interpolated the diurnal temperature range (DTR) as an indicator of forest microclimate across a 4338 ha section of the forest with 50 m spatial resolution. Microclimate heterogeneity was measured as α-, β-, and γ-diversity of thermal niches (i.e. DTR classes).

Results
Even-aged forests showed a higher γ-diversity of microclimates than uneven-aged and unmanaged forests. This was mainly due to a higher β-diversity resulting from the spatial coexistence of different forest developmental stages within the landscape. The greater structural complexity at the stand-level in uneven-aged stands did not increase α-diversity of microclimates. Predicted DTR was significantly lower and spatially more homogenous in unmanaged forest compared to both types of managed forest.

Conclusion
If forest management aims at creating a wide range of habitats with different microclimates within a landscape, spatially co-existing types of differently managed and unmanaged forests should be considered, instead of focusing on a specific type of management, or setting aside forest reserves only.
Epistemic deontology, epistemic trade-offs, and Kant’s formula of humanity
Authors: Andow James 
Published: January 2023

AbstractAn epistemic deontology modelled on Kant’s ethics—in particular the humanity formula of the categorical imperative—is a promising alternative to epistemic consequentialism because it can forbid intuitively impermissible epistemic trade-offs which epistemic consequentialism seems doomed to permit and, most importantly, it can do so in a way that is not ad hoc.