bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Efficiency of the CT Radiomics Model in Assessing the Microsatellite
Instability of Colorectal Cancer Liver Metastasis
Authors: Wang Yun , Ma Luyao , Guo Haifeng , Wang Xuehua , Ye Zhaoxiang , Fan Shuxuan , Gao Bulang , Yin Xiao-Ping 
Published: August 2023

Objective:
This study aims to investigate the efficiency of a radiomics model in identifying high-frequency microsatellite instability (MSI-H) and microsatellite stability (MSS) of colorectal liver metastasis (CRLM) according to machine learning radiomics features of enhanced CT liver images.

Materials and Methods:
A total of 12 patients with MSI-H CRLM and 96 patients with MSS CRLM were randomly divided into the training group and internal validation group according to the ratio of 7: 3 (training: 75 cases, validation: 33 cases). From the enhanced CT (portal phase) image data of patients, 788 radiomics features were extracted, and a random forest model was established with the optimal features selected. The receiver operating characteristics (ROC) curve analysis was performed to assess the model’s diagnostic efficacy.

Results:
The training group comprised 8 patients with MSI-H CRLM and 67 patients with MSS CRLM, and the internal validation group included 4 patients with MSI-H CRLM and 29 patients with MSS CRLM. After feature selection, 7 radiomics features good for distinguishing MSI-H CRLM and MSS CRLM were screened out. The ROC curve analysis demonstrated that the random forest model had the AUC (area under the ROC curve) value 0.88, accuracy 0.85, sensitivity 0.85, specificity 0.92, and F1 score 0.88 in the training group. The model had an AUC value of 0.75, accuracy of 0.74, sensitivity of 0.81, specificity of 0.85, and F1_score of 0.78 in the internal validation group in identifying the MSI-H from the MSS CRLM. In order to evaluate the robustness of the overall model, the 788 features obtained were all applied to the 5-fold cross-validation, with the model being built on the random forest and analyzed with the ROC curve analysis. The AUC value of the model was 0.86 (P＜0.05), accuracy value 0.91, sensitivity 0.60, and specificity 0.95.

Conclusion:
The random forest prediction model built on the radiometric features extracted from enhanced CT images can be used to identify the MSI-H from the MSS CRLM and may provide effective guidance for clinical immunotherapy of CRLM patients with unknown MSI status.
Transformer and Graph Transformer-Based Prediction of Drug-Target
Interactions
Authors: Qian Meiling , Lu Weizhong , Zhang Yu , Liu Junkai , Wu Hongjie , Lu Yaoyao , Li Haiou , Fu Qiming , Shen Jiyun , Xiao Yongbiao 
Published: August 2023

Background:
As we all know, finding new pharmaceuticals requires a lot of time and money,
which has compelled people to think about adopting more effective approaches to locate drugs. Researchers have made significant progress recently when it comes to using Deep Learning (DL) to create DTI

Methods:
Therefore, we propose a deep learning model that applies Transformer to DTI prediction. The
model uses a Transformer and Graph Transformer to extract the feature information of protein and compound molecules, respectively, and combines their respective representations to predict interactions.

Results:
We used Human and C.elegans, the two benchmark datasets, evaluated the proposed method in
different experimental settings and compared it with the latest DL model.

Conclusion:
The results show that the proposed model based on DL is an effective method for the classification and recognition of DTI prediction, and its performance on the two data sets is significantly better
than other DL based methods.
An Update on Potential Antidepressants Derived from Marine Natural
Products
Authors: Shejul Priya P. , Raheja Radhika K. , Doshi Gaurav M. 
Published: August 2023

Introduction:
Depression is one of the most frequently occurring psychiatric disorders
worldwide, affecting 121 million worldwide. World Health Organization (WHO) estimates that it
is the leading cause of disability and the fourth leading contributor to the "global burden of diseases".

Objective:
Investigating and developing a drug with a novel benefit-risk profile is critical. Marine
sources have been explored for their benefits as an alternative therapy for depression treatment.
Numerous studies have shown that natural compounds containing peptides, alkaloids, polyphenols,
diterpenes, glycosides, vitamins, and minerals from marine sources can potentially treat a
wide range of disorders, including depression. Such phytoconstituents are known to reduce oxidative
stress and neuroinflammation, regulate the synthesis or function of neurotransmitters such as
glutamate and acetylcholinesterase, and aid in enhancing serotonin levels and nerve development.

Methods:
In this review study, a literature search was conducted using terms often used, including
animal models of depression and their precise phases, marine sources, algae, sponges, and indole
alkaloids. Additionally, databases were examined, including Scopus, Wiley, Elsevier, Google
Scholar, and Web of Science. The Snowball technique was used to identify several articles about
depression but correlated to marine sources in addition to database searches.

Results:
Current antidepressant medications have several negative side effects on the human
body, including dry mouth, cardiovascular interference, gastrointestinal symptoms, genitourinary
symptoms, hepatotoxicity, convulsions, and obesity. As a result, researchers can identify a wide
range of potential targets for medications derived from marine sources. A combination of marinederived
drugs and available treatments can be estimated to minimize the negative effects. So that
these resources can be used as efficiently as possible, and various marine-derived substances can
be studied for therapeutic efficacy.

Conclusion:
This review focuses on the preclinical and clinical findings of marine-derived compounds
with antidepressant properties that alter behavioural parameters and biochemical abnormalities,
as well as their mechanism of action and in-vivo potential.
In silico Study of Alkaloid Compounds with Computational Approach for
Selection of Drug Leads for COVID-19
Authors: Victoria Stephanie Audrey , Pramanda Ihsan Tria , Parikesit Arli Aditya 
Published: August 2023

Background:
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virulent source of COVID-19 disease. As a result of the rapid transmission of the viral agent and deficiency of specific drugs against the virus, a worldwide pandemic ensued with a terrifying death toll. Thus there is tremendous urgency to discover substances for the development of specific COVID-19 drugs. With increasing public interest in natural products, this study aims to discover alkaloid compounds capable of inhibiting SARS-CoV-2 with the assistance of bioinformatics.

Methods:
In this work, 298 alkaloids with reported antiviral properties were identified, and their biological activities were validated with QSAR analysis using the Pass Online server until only 7 alkaloids remained. Molecular docking studies for these 7 alkaloids onto SARS-CoV-2 3CLpro, a protein involved in viral replication, were carried out with AutoDock Vina, followed by in silico visualization of the protein-alkaloid interaction with Ligplot+ program and prediction of ADME-Tox properties of the alkaloids using Toxtree program and SwissADME online server.

Results:
Fangchinoline, phenanthroindolizidine, and polyalthenol are predicted to have strong binding affinity with SARS-CoV-2 3CLpro. Visualization of the molecular interactions between the ligand and protein target, however, showed that homonojirimycin formed the most hydrogen bonds with the protein binding site. Most of the alkaloids have little to no violation of Lipinski’s Rule of 5, easy to moderate synthetic accessibility, and good pharmacokinetic properties.

Conclusion:
Fangchinoline, phenanthroindolizidine, and polyalthenol exhibited high binding affinity values to SARS-CoV-2 3CLpro, with polyalthenol predicted to possess the strongest binding interactions to the active site of the protein. Polyalthenol and phenanthroindolizidine confer the most versatility in terms of bioavailability, however, supplementary observation of phenanthroindolizidine for the prospect of mutagenicity is required before it can be recommended for further drug development
ANALISA YURIDIS TERHADAP MODEL KEWENANGAN JUDICIAL REVIEW DI INDONESIA
Authors: Simamora Janpatar 
Published: August 2023

One of the fundamental changes on judicial power in the third amendment of UUD 1945 is the distributionof judicial review power to Supreme Court and Constitutional Court. The Supreme Court has the highestjurisdiction to execute the cassation cases and authority to review inferior regulations under law. TheConstitutional Court has the power to review laws against UUD 1945. Unfortunately, the judicial reviewmodel has several potential problems which can ruin the implementation of legal principles. That is whysome changes have to be taken. Salah satu poin mendasar dari penataan kekuasaan kehakiman pada perubahan ketiga UUD NRI Tahun1945 adalah dilakukannya pengaturan kewenangan judicial review atau hak menguji yang dijalankan oleh lembaga pelaksana kekuasaan kehakiman, yaitu Mahkamah Agung dan Mahkamah Konstitusi. Mahkamah Agung berwenang mengadili pada tingkat kasasi, menguji peraturan perundang-undangan di bawah Undang-Undang terhadap Undang-Undang, sedangkan Mahkamah Konstitusi berwenang menguji Undang-Undang terhadap Undang-Undang Dasar. Namun ternyata model kewenangan judicial review semacam ini rentan melahirkan persoalan hukum yang dapat merusak pilar-pilar hukum, sehingga perlu dilakukan penataan ulang.
POLICY, PROTECTION OF POLICYHOLDER, AND LIFE INSURANCE EDUCATION TO THE SOCIETY
Authors: Kartika Hana Sri Juni 
Published: August 2023

Changes towards betterment of policyholder protection is not proportional to the growth of life insurance company. Policyholders encounter difficulties in asserting their rights when their life insurance companyis in financial straits and served with bankruptcy petition. Life insurance company and regulator have tore-regulate in detail every possible provision contained in a life insurance and ensure that each clausehas been incorporated in the policy, to protect policyholder. The society must be educated to the rightsand responsibility of the policyholder and the insurer, including the protection accorded to policyholders when the life insurance company is on the edge of financial distress or bankruptcy. Peningkatan perlindungan bagi pemegang polis belumlah memadai jika dibandingkan dengan pertumbuhan industri perasuransian. Pemegang polis menghadapi kesulitan untuk mendapatkan haknya ketika perusahaan asuransi menghadapi kondisi keuangan yang tidak sehat dan kebangkrutan. Perusahaan asuransi dan pembuat undang-undang harus mengatur kembali secara rinci semua klausul yang diperlukan dan memastikan bahwa klausul tersebut sudah termuat dalam polis asuransi, khususnyahal-hal yang mengatur mengenai perlindungan bagi pemegang polis asuransi jiwa. Masyarakat perlu diedukasi tentang hak dan tanggungjawab dari pemegang polis dan perusahaan asuransi selaku penjamin, termasuk mengenai perlindungan pemegang polis ketika perusahaan asuransi jiwa menghadapi masalah keuangan atau kebangkrutan.
PENJAMINAN KREDIT USAHA KECIL MELALUI GIRALISASI DAN TRANSMISI JAMINAN KEBENDAAN MENJADI TUNAI
Authors: Muwarji Tarsisius 
Published: August 2023

‘Giralisasi’ is the transformation of a physical guarantee (fixed asset) into cash guarantee. Through a pledge/collateral agreement, assets are given by the owner to an issuing bank. The asset is then givena cash value. The cash value is put into an account and transferred to another bank through SocietyWorldwide Interbank Financial Telecommunication (SWIFT) to guarantee credit for small to mediumscale enterprises. This process and the transformation of guarantees may become an alternative solutionto credit issues faced by small to medium scale enterprises when applying for bank loans. Giralisasi merupakan transformasi jaminan benda menjadi jaminan tunai. Dengan perjanjian gadai, aset diserahkan pemilik kepada bank penerbit, dinilai dengan uang, dimasukkan kedalam rekening dan ditransmisikan ke bank lain melalui Society Worldwide Interbank FinancialTelecommunication (SWIFT) untuk menjamin kredit UKM. Giralisasi dan transformasi jaminanini dapat menjadi alternatif solusi permasalahan jaminan bagi UKM memperoleh kredit bank.
KENDALA HAKIM DALAM MENCIPTAKAN KEPASTIAN HUKUM, KEADILAN, DAN KEMANFAATAN DI PERADILAN PERDATA
Authors: Wantu Fence M. 
Published: August 2023

The obstacles faced by a judge in realizing the principles of legal certainty, justice, and utility can be categorized into internal and external obstacles. Internal obstacles, which come from within the judgeconsist of: the appointment of the judge, his education, his understanding of science and knowledge, hismorality, and his welfare. On the other hand, external obstacles, which comes from outside the judge,consist of: the independence of judicial power, the formulation of legislations, the prevailing judicialsystem, community participation, and judge supervision. Kendala yang dihadapi hakim dalam mewujudkan kepastian hukum, keadilan dan kemanfaatan dapat dibedakan menjadi kendala internal dan kendala eksternal. Kendala internal yang datangnya daridalam diri sendiri. Kendala internal terdiri dari: pengangkatan hakim, pendidikan hakim, penguasaanterhadap ilmu pengetahuan, moral hakim, kesejahteraan hakim. Sementara kendala eksternal datangnyadari luar diri hakim itu sendiri. Kendala eksternal hakim terdiri sebagai berikut, kemandirian kekuasaankehakiman, pembentukan undang-undang, sistem peradilan yang berlaku, partisipasi masyarakat,pengawasan hakim.
PERAN PEMERINTAH DALAM PENANGGULANGAN PENCEMARAN AIR TANAH OLEH BAKTERI E. COLI DI KOTA YOGYAKARTA
Authors: Winarni Fajar , Puspitasari Dinarjati Eka 
Published: August 2023

This study is an empirical legal research that uses primary and secondary data. The result of this study is to be used f or the handling of E. coli contamination where it is the government ’s role to procure chlorine diffusers and monitor the quality of drinking water. The high level of contamination caused by the E. coli bacteria is due to the poor sanitation system and the close proximity of wells to septic tanks. Meanwhile, other constraints faced by the government include the lackof routine monitoring, lack of sanitation workers, and lack of proper implementation of the standardtechnical guidance on Procedures Planning Septic Tank with Absorption Systems. Penelitian ini merupakan penelitian hukum empiris yang menggunakan data primer dan sekunder. Hasil penelitian ini adalah dalam rangka penanggulangan pencemaran bakteri E. coli dimana Pemerintahberperan dalam pengadaan alat chlorine diffuser, sosialisasi hidup bersih, pengawasan kualitas air minum, dan sebagainya. Tingginya pencemaran bakteri E. coli dikarenakan sistem sanitasi yang buruk, dan jarakyang dekat antara sumur dengan saluran septic tank. Sementara itu kendala yang dihadapi antara lainPemerintah tidak melakukan pengawasan secara rutin, terbatasnya petugas sanitasi, tidak dilaksanakannyapetunjuk teknis SNI tentang Tata Cara Perencanaan Tangki Septik dengan Sistem Resapan.Kata Kunci: peran pemerintah, pencemaran, bakteri E. coli.
THE IMPLEMENTATION OF NATURAL DISASTER MANAGEMENT PROGRAM IN INDONESIA BETWEEN 2007 AND 2013
Authors: Triyana Heribertus Jaka 
Published: August 2023

This article focuses on the implementation of the natural disaster management program (NDMP) after the promulgation of Act No. 24 of 2007 on Disaster Management. This implementation will be viewed both from legal and political frameworks. The aim of this article is twofold: First, to assess whether the community-based natural resources management system principle in Act No. 24 of 2007 has been implemented as the core principle for executing the NDMP. Second, to evaluate the hindrance caused by political decentralization to the effective implementation of the NDMP under Act No. 24 of 2007 as taken by local governments under the community-based natural resources management system principle. Artikel ini fokus pada pelaksanaan program penanggulangan bencana alam setelah diundangkannya Undang-Undang Nomor 24 Tahun 2007 tentang Penanggulangan Bencana dengan menggunakan perspektif kerangka hukum dan politik. Tujuan artikel ini ada dua: Pertama, untuk menilai apakah prinsip pengelolaan sumberdaya alam berbasis masyarakat dalam Undang-Undang Nomor 24 Tahun 2007 telah diimplementasikan sebagai prinsip inti untuk melaksanakan program penanggulangan bencana alam tersebut. Kedua, untuk mengevaluasi kendala yang disebabkan oleh desentralisasi politik terhadap keefektifan pelaksanaan program penanggulangan bencana alam menurut Undang-undang Nomor 24 Tahun2007 sebagaimana ditempuh oleh pemerintah daerah di bawah prinsip sistem pengelolaan sumber dayaalam berbasis masyarakat.
THE REFORM OF CORRUPTION ERADICATION IN INDONESIA: THE PRISMATIC LAW IN THE RECENT CONTEXT
Authors: Akbar Muhammad Fatahillah , Wicaksono Dian Agung 
Published: August 2023

This paper aims to investigate the reform of corruption eradication in Indonesia from three crucial aspects: the form of the Corruption Eradication Commission (KPK), the formulation of corruption in material and formal aspects, and other additional support system such as asset recovery and the protection of justice collaborator and whistle blower. This paper is a normative-legal research where it dissects secondary data which includes statutory regulations, various legal documents, researches, and other references relevant to corruption eradication in Indonesia. KPK could be strengthened in particular aspects with changes in regards its design of authority and its relationship with other authorities in corruption eradication process. Artikel ini bertujuan untuk meneliti reformasi pemberantasan korupsi dari tiga aspek penting: bentuk dari Komisi Pemberantasan Korupsi, perumusan korupsi dalam aspek materiil maupun aspek formiil, serta hal-hal pendukungnya seperti pemulihan aset dan perlindungan justice collaborator dan whistleblower. Tulisan ini merupakan penelitian hukum normatif yang menelaah data sekunder. Data sekunder yang ditelaah antara lain adalah peraturan perundang-undangan, berbagai dokumen hukum, penelitian, dan referensi lainnya yang relevan dengan pemberantasan korupsi di Indonesia. Komisi Pemberantasan Korupsi (KPK) akan diperkuat dalam aspek tertentu dengan diubahnya desain wewenang serta koordinasi hubungan antara KPK dan pihak berwenang lainnya dalam pemberantasan korupsi.
KESEIMBANGAN HAK DAN KEWAJIBAN PEKERJA DAN PENGUSAHA DALAM MOGOK KERJA
Authors: Hernawan Ari 
Published: August 2023

This juridical-normative research was conducted on the basis of secondary data as its primary source. We analysed the data using qualitative method and present our findings in a descriptive discussion. This research studies the balance of rights and obligations of workers and employers by analyzing Act Number 13 of 2004 on Manpower. In the same regulation, it was found that there was no balance in the rights of workers and employers in situation of a labour strike. The provisions in the regulation hinders strikes to be legally initiated, this is seen from the inbalance in strike and lock out provisions where procedures to initiate a strike is made to be more difficult. Penelitian ini bersifat yuridis normatif, mendasarkan pada data sekunder sebagai sumber data utama. Data yang diperoleh dari penelitian dianalisis secara kualitatif. Hasil analisis selanjutnya disajikan dalam bentuk uraian yang bersifat deskriptif.Penelitian ini dilakukan untuk menjawab pertanyaan bagaimanakah perimbangan hak dan kewajiban pekerja dan pengusaha dari segi teks Undang-Undang Nomor 13 Tahun 2003 tentang Ketenagakerjaan. Kesimpulan yang didapatkan bahwa memang ada ketidakseimbangan hak pekerja dan pengusaha dalam ketentuan mogok kerja yang diatur dalam Undang-Undang Ketenagakerjaan. Terdapat ketentuan yang dapat menyulitkan mogok berlangsung secara sah, ketidakseimbangan juga terlihat jika ketentuan mogok kerja dibandingkan dengan ketentuan lock out yang merupakan hak dasar pengusaha.
KAJIAN SEMANTIK TERHADAP PRODUK HUKUM TERTULIS DI INDONESIA
Authors: Said Ikhwan M. 
Published: August 2023

This study aims at revealing two prime points (1) how is Indonesian Language utilized in legal practice in Indonesia and (2) which method is frequently used by legal practitioners in interpreting a certain word? This is a descriptive-qualitative study. The data of the research are sentences or phrases taken randomly from the criminal code (KUHPidana), civil code (KUHPerdata), trade code (KUHDagang), decrees, explanations of legislation (laws). The analysis employed is descriptive and prescriptive. It was figured out that the use of Indonesian language in legal aspect was manifested in seven processes: translation, abstraction, association, typology, meaning emphasis, simplicity, and legal choices. While the interpretive method used is interpretations and construction methods. Tulisan ini bertujuan menjawab dua persoalan, yaitu (1) bagaimana wujud penggunaan bahasa Indonesia dalam praktik hukum di Indonesia, dan (2) metode yang seringkali digunakan oleh praktisi hukum dalam menginterpretasikan suatu kata. Jenis penelitian yang digunakan adalah deskriptif kualitatif. Datanya adalah kalimat atau frasa yang diambil secara acak dari KUHPidana, KUHPerdata, KUHDagang, surat-surat keputusan, dan penjelasan undang-undang. Analisis datanya adalah analisis deskriptif dan preskriptif. Diketahui bahwa wujud penggunaan bahasa Indonesia dalam bidang hukum ada tujuh proses (penerjemahan, abstraksi, asosiasi, tipologi, penekanan makna, pemadatan, dan pilihan hukum). Sementara metode penginterpretasiannya adalah metode penafsiran dan metode konstruksi.
PEMBERDAYAAN TERHADAP KINERJA ANGGOTA DEWAN PERWAKILAN RAKYAT DAERAH KOTA DEPOK JAWA BARAT
Authors: Kadarisman Muh. 
Published: August 2023

Organisation performance is of the utmost importance, as through performance the degree of achievement can be seen. Such achievement must be in accordance with the pre-determined mission as a ground to complete the tasks. This study aims to learn the effect of empowerment towards the performance of Depok City Legislation Council. This study employs a quantitative approach and the path analysis model. The research results shows: (1) the effect of the empowerment to DPRD performance is significant, (2) the effect of a collaborative team on DPRD performance is not significant, (3) the effect of the superior on DPRD performance is not significant, and (4) the effect of communication effort on the DPRD performance is not significant. Kinerja suatu organisasi sangat penting, karena dengan adanya kinerja maka tingkat pencapaian hasil akan terlihat. Tingkat pencapaian tersebut seharusnya sesuai dengan misi yang telah ditetapkan sebagai landasan untuk melakukan tugas yang diemban. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh pemberdayaan atas kinerja DPRD Depok. Penelitian ini menggunakan pendekatan kuantitatif serta analisis jalur (path analysis). Dari hasil penelitian yang diperoleh dapat diketahui bahwa pengaruh pemberdayaan atas kinerja DPRD signifikan, pengaruh tim yang mampu kerjasama atas kinerja Anggota DPRD tidak signifikan. Pengaruh pimpinan atas kinerja Anggota DPRD tidak signifikan, dan pengaruh komunikasi atas kinerja Anggota DPRD tidak signifikan.