bluuebunny/crossref_metadata_2025_split huggingface dataset:
Um réquiem para o liberalismo tardio é necessariamente um réquiem para a demarcação ontológica entre vida e não-vida?
Authors: Magalhães Beatriz Judice 
Published: January 2025

Em Geontologias, Povinelli conecta reflexões teóricas sobre formas de poder, ontologias, descrições de episódios etnográficos e análises geopolíticas para se debruçar sobre considerações teóricas mais gerais relacionadas ao Antropoceno, mais especificamente às questões de poder conectadas a essa irrupção da atenção para as conformações geológicas estabelecidas pelos humanos, bem como às suas implicações ontológicas. A autora também se debruça sobre o liberalismo tardio de ocupação, termo que faz referência às relações entre grupos indígenas, Estados e empreendimentos econômicos conformadas nas últimas décadas, em que se associam características da opressão colonial sobre as populações autóctones a algumas políticas de reconhecimento.
Elisabeth Vigée-LeBrun: Artist, Adventurer, Auto-Biographer
Authors: Russo Kathleen Lucey 
Published: January 2025

Abstract
Elisabeth Vigée-LeBrun (1755–1842) was one of the most prolific and successful portrait painters in history. She was patronized by many powerful and aristocratic people of the age, most notably Queen Marie Antoinette, of whom she painted many portraits and with whom she had much in common. This included scandal for both of these women of the same age, particularly regarding rumored lovers. The Comte de Vaudreuil and the Comte de Calonne were two of these men painted by Vigée-LeBrun. Vigée-LeBrun also painted many beautiful self-portraits, including those with her daughter, Julie. Some of the best known are those that she executed in Italy after exile from France. These include the self-portraits that she did for the Uffizi Gallery in Florence and for the Accademia di San Luca, Rome. She herself was so pleased with these works that she painted many copies of them. They include a copy of the Uffizi Self-Portrait for Lord Bristol, the Duke of Berry, and a newly discovered copy of the San Luca Self-Portrait, now in the Haukohl family Collection. Her travels in exile included many cities in Italy and also throughout Europe, including Vienna, where she painted a portrait of the Countess Bucquoi, amongst many other Austrian and Polish nobles. During her long stay in Russia (1795–1801), she painted almost every aristocrat of note, excluding Catherine the Great. She was also admitted to the Royal Academy of Painting in Saint Petersburg, one of many Art Academies to grant her membership. Her many works (660 portraits, 200 landscapes mostly in pastel, and history paintings), show a progression of style from a lush late rococo to a drier neo-classical style and eventual romanticism, indicative of the changes in style throughout her long life. Pardoned by Napoleon, she returned to Paris in 1802, concentrating in her later life on the writing of her Memoirs (Souvenirs), which include many personal stories regarding her life and career.
Use of patient portals to disclose STI test histories to sex partners among U.S. men who have sex with men: A call for research and guidance
Authors: Jackman Kevon-Mark P. , Atkins Kaitlyn , Murray Sarah M. , Carpino Tom , Lucas Iaah , Sanchez Travis , Baral Stefan 
Published: January 2025

Background This study investigates the use of patient portals for disclosing sexually transmitted infection (STI) test result histories to sexual partners among men who have sex with men (MSM) in the United States. Methods Using data from the 2022-2023 American Men’s Internet Survey, this cross-sectional analysis examined demographic, behavioral, and healthcare-related factors associated with MSM’s utilization of patient portals for sharing STI test results. Participants ( N = 2601) were surveyed on portal use, STI testing frequency, and partner disclosure practices. Results 18% of survey participants used portals to disclose a STI test result to parrtners, with higher prevalences among individuals aged 16–37 years old versus 56 years and older, black non-Hispanic (26.4%) versus white non-Hispanic (16.8%), and those reporting nine or more times being tested for STIs (30.1%) versus 1 to 3 times (7.5%). Participants reporting sex work (33.3% vs 17.7%) and HIV pre-exposure prophylaxis (PrEP) use (24.2% vs 13.0%) also had a higher prevalence of portal use for disclosure. Multivariable Poisson regression analysis with robust error variance showed that sexual behavioral stigma from family and friends [adjusted prevalence ratio (aPR) = 1.11; p = .04] also, being tested for STIs four to 8 (aPR = 2.21; p < .001) and nine or more times aPR = 3.42; p < .001) were significantly associated with prevalence of portal-based disclosure. Conclusion Findings suggest patient portals may be viable tools for STI prevention in MSM communities, especially among individuals with increased vulnerability to STI acquisition. Addressing disparities in portal access and explaining patient portal capabilities may enhance the role of digital health in reducing STI transmission among MSM communities.
Police Communications Centre Mental Health Liaison Service: Enhancing outcomes for people in mental health crisis
Authors: Payne Leanne , Meurk Carla , Waterson Elissa , Heffernan Ed 
Published: January 2025

Objective To describe the Police Communication Centre Mental Health Liaison Service (PCC MHLS), a novel mental health service embedded in a Queensland Police Service (QPS) communication centre which provides real-time information and advice to police as first responders to people in mental health crisis. Methods A retrospective analysis of referrals received from 1st January 2023 to 31st December 2023 was conducted. Descriptive statistics were calculated for consumer and service episode characteristics and reported outcomes. Results The service received 3549 referrals with a daily mean of 9.97. Mean age at referral was 38.11 years ( SD 15.86, range 6–102), and most consumers were male (60.4%). 41 percent did not have a current or historic psychiatric diagnosis and 28.1% were open to the public mental health service. The most reported presenting problem was suicide/self-harm (45.2%). An Emergency Examination Authority was enacted in 28.3% of cases, and 20.9% of consumers were referred to mental health services. Conclusion Results suggest some consumers may be experiencing psychological distress rather than diagnosed mental illness. The PCC MHLS connects consumers with the most appropriate services beyond hospital emergency departments and provides a novel and effective mechanism for real-time support for first responses to people in mental health crisis.
Stratification of Anatomical Imaging Features Between High-Risk and Non-High-Risk Groups in Neuroblastoma
Authors: Wang Haoru , Chen Xin , He Ling , Cai Jinhua 
Published: January 2025

Background This study compared anatomical imaging features between high-risk and non-high-risk groups in neuroblastoma with at least one image-defined risk factor (IDRF). It also assessed the diagnostic performance of these features in identifying the high-risk group. Methods A retrospective analysis of neuroblastoma patients with at least one IDRF was conducted. Imaging features, including estimated tumor volume and IDRFs, were compared between the two groups. The diagnostic performance of these features was assessed using receiver operating characteristic (ROC) curves, and the areas under the ROC curves (AUCs) along with their 95% confidence intervals (CIs) were calculated. Additionally, to internally validate their diagnostic performance, the bootstrap resampling method with 1000 bootstrap resamples was employed. Results The study included 255 patients (185 high-risk cases, 70 non-high-risk cases). Significant differences were found in estimated tumor volume and IDRF number between the high-risk and non-high-risk groups ( P < 0.001). The estimated tumor volume and the IDRF number-based cluster were independent risk factors, and their combination achieved an AUC of 0.801 (95% CI: 0.747-0.848) for high-risk group diagnosis, with the average AUC of the 1000 bootstrap samples of 0.800 (95% CI: 0.798-0.802). In abdominal lesions, specific IDRF categories differed between high-risk and non-high-risk groups ( P < 0.05). Conclusion Our study reveals anatomical imaging differences between high-risk and non-high-risk groups in neuroblastoma with at least one IDRF.
DISCOntinuation of disease-modifying therapies in MS: The DISCOMS extension trial
Authors: Corboy John R , Fox Robert J , Cutter Gary , Engebretson Eric , Miller Aaron , Morgan Charity , Gustafson Tarah , Goodman Andrew D , Kannan Meena , Sriram Subramanian , Xia Zongqi , Lynch Sharon , Bowen James , Kister Ilya 
Published: January 2025

Background: In the DISCOMS (DISCOntinuation of disease-modifying therapies (DMTs) in multiple sclerosis (MS)) randomized clinical trial, we could not demonstrate that discontinuing MS DMTs in older, stable adults was not inferior to continuing DMTs. Relapses were rare in both groups, and most new disease activity was one to two new brain magnetic resonance imaging (MRI) lesions unassociated with clinical changes. Objective/Aims: Describe results of the DISCOMS extension study. Methods: Among 10/19 of the original sites, we enrolled patients who completed DISCOMS; did not reach the primary endpoint during the original trial; and retained original randomized assignment. Participants completed one study visit and brain MRI at least 30 months after original enrollment in DISCOMS. Primary endpoint was time from entry into the primary study to relapse or new brain MRI activity. Results: Mean (SD) total follow-up was 40 (11.7) months. There were no relapses, and new brain MRI lesions (1/30 continuer, 2/44 discontinuers) were uncommon during the extension. Time from primary trial entry to disease event was significantly shorter for subjects in the discontinue group ( p = 0.043 from log-rank test). Conclusions: From entry into DISCOMS extension study, time to new MS activity remained shorter in discontinuers, but relapses were absent and new brain MRI lesions were rare.
Exploration of Molecular Mechanisms and Potential Traditional Chinese Medicine Intervention in Acute Liver Injury
Authors: Liu Xiling , Fu Xin , Shen Kuiling , Li Yaoqi , Kang Xichun , Li Shenghao , Yuan Wenfang , Lu Jianhua , Yan Huimin 
Published: January 2025

Objective This study aimed to explore the potential targets and molecular mechanisms underlying the progression of acute liver injury, as well as to predict traditional Chinese medicines associated with key targets. Methods Differentially expressed genes (DEGs) associated with acute liver injury were first screened. Then immune infiltration analysis was performed using CIBERSORT algorithm, followed by Weighted Gene Co-Expression Network Analysis (WGCNA) analysis. Subsequently, Gene Ontology (GO) and Kyoto Encyclopedia of Genomes (KEGG) analyses of overlapping genes between DEG and WGCNA were performed using the DAVID database. The main active components of the predicted Chinese medicines were determined through network pharmacology analysis. In vitro experiment was performed to observe the effects of different concentrations of quercetin on the inflammatory response of LPS-induced J774A.1 macrophages. Results The results showed elevated M1 macrophages and activated dendritic cells in acute liver injury. A total of 40 DEGs associated with M1 macrophages were obtained, which were significantly enriched in four pathways, including the Toll-like receptor signaling pathway ( P < .05). Furthermore, eight potential traditional Chinese medicines associated with Toll-like receptor signaling were identified, and network pharmacological analysis revealed quercetin as their main active ingredient. In vitro experimental results showed that quercetin reduced the mRNA levels of IL-6, TNF-α, IL-1β, and NF-κB as well as the protein levels of IL-6 and TNF-α in LPS-induced macrophages ( P < .05). Additionally, quercetin significantly inhibited the release of NO ( P < .05). Conclusion The present study provides further evidence that M1 macrophages potentially exert pro-inflammatory effects in acute liver injury via the toll-like receptor pathways. Notably, quercetin demonstrates inhibitory properties in this process, and its mechanism of action may be intricately linked to the TLR4-NF-κB signaling pathway.
Factor XIa Inhibitor Reversal in Intracranial Hemorrhage: A Case Report
Authors: Al-Obeidi Arshed , Garavito Draia , Smalley Sierra , John Kayla , Jones Lee Ann , Key Nigel , Strohm Tamara 
Published: January 2025

Background/Objectives There is currently no consensus regarding the optimal strategy for reversal of anticoagulation in life-threatening hemorrhage associated with factor XIa (FXIa) inhibitors. Methods For this clinical case report, informed consent was obtained from surrogate. Results and Discussion Here, we present the case of an 82-year-old female who sustained a large subdural hematoma after a fall. Her aPTT on admission was elevated at 90.4 s and remained persistently prolonged at 90.9 s 12-hour after receiving an adequate dose of 4-factor prothrombin complex concentrate (PCC). She was found to have received a factor XIa inhibitor in a clinical trial, and subsequently received recombinant activated factor VII (rFVIIa) 2 mg (45 mcg/kg) as a one-time dose, and tranexamic acid (TXA) 1 g intravenously for reversal given her intracranial bleeding in the setting of trauma complicated by recent factor XIa inhibitor use. However, given her clinical decline and high surgical risk, the patient’s family elected to withdraw care and she expired three days later. Reversal of FXIa inhibitors is challenging but may best be achieved using a combination of rFVIIa and TXA. Practical Implications Clinicians should consider administration of low dose recombinant activated factor VII (rFVIIa) in conjunction with an anti-fibrinolytic inhibitor such as tranexamic acid (TXA) for reversal of life-threatening hemorrhage in bleeding patients with exposure to novel factor XIa inhibitors that are currently in clinical trials.
Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article
Authors: Mehdi Syed Faizan , Qureshi Muhammad Hamza , Pervaiz Salman , Kumari Karishma , Saji Edwin , Shah Mahnoor , Abdullah Ahmad , Zahoor Kamran , Qadeer Hafiza Amna , Katari Disha Kumari , Metz Christine , Mishra Lopa , LeRoith Derek , Tracey Kevin , Brownstein Michael J. , Roth Jesse 
Published: January 2025

Abstract
Severe sepsis is cognate with life threatening multi-organ dysfunction. There is a disturbance in endocrine functions with alterations in several hormonal pathways. It has frequently been linked with dysfunction in the hypothalamic pituitary-adrenal axis (HPA). Increased cortisol or cortisolemia is evident throughout the acute phase, along with changes in the hypothalamic pituitary thyroid (HPT) axis, growth hormone-IGF-1 axis, insulin-glucose axis, leptin, catecholamines, renin angiotensin aldosterone axis, ghrelin, glucagon, hypothalamic pituitary gonadal (HGA) axis, and fibroblast growth factor-21. These changes and metabolic alterations constitute the overall response to infection in sepsis. Further research is essential to look into the hormonal changes that occur during sepsis, not only to understand their potential relevance in therapy but also because they may serve as prognostic indicators.
ClearFinder: a Python GUI for annotating cells in cleared mouse brain
Authors: Pastore Stefan , Hillenbrand Philipp , Molnar Nils , Kovlyagina Irina , Chongtham Monika Chanu , Sys Stanislav , Lutz Beat , Tevosian Margarita , Gerber Susanne 
Published: January 2025

Abstract

Background
Tissue clearing combined with light-sheet microscopy is gaining popularity among neuroscientists interested in unbiased assessment of their samples in 3D volume. However, the analysis of such data remains a challenge. ClearMap and CellFinder are tools for analyzing neuronal activity maps in an intact volume of cleared mouse brains. However, these tools lack a user interface, restricting accessibility primarily to scientists proficient in advanced Python programming. The application presented here aims to bridge this gap and make data analysis accessible to a wider scientific community.

Results
We developed an easy-to-adopt graphical user interface for cell quantification and group analysis of whole cleared adult mouse brains. Fundamental statistical analysis, such as PCA and box plots, and additional visualization features allow for quick data evaluation and quality checks. Furthermore, we present a use case of ClearFinder GUI for cross-analyzing the same samples with two cell counting tools, highlighting the discrepancies in cell detection efficiency between them.

Conclusions
Our easily accessible tool allows more researchers to implement the methodology, troubleshoot arising issues, and develop quality checks, benchmarking, and standardized analysis pipelines for cell detection and region annotation in whole volumes of cleared brains.
Population genomics of a natural Cannabis sativa L. collection from Iran identifies novel genetic loci for flowering time, morphology, sex and chemotyping
Authors: Mostafaei Dehnavi Mahboubeh , Damerum Annabelle , Taheri Sadegh , Ebadi Ali , Panahi Shadab , Hodgin George , Brandley Brian , Salami Seyed Alireza , Taylor Gail 
Published: January 2025

Abstract

Background
Future breeding and selection of Cannabis sativa L. for both drug production and industrial purposes require a source of germplasm with wide genetic variation, such as that found in wild relatives and progenitors of highly cultivated plants. Limited directional selection and breeding have occurred in this crop, especially informed by molecular markers.

Results
This study investigated the population genomics of a natural cannabis collection comprising male and female individuals from various climatic zones in Iran. Using Genotyping-By-Sequencing (GBS), we sequenced 228 individuals from 35 populations. The data obtained enabled an association analysis, linking genotypes with key phenotypes such as inflorescence characteristics, flowering time, plant morphology, tetrahydrocannabinol (THC) and cannabidiol (CBD) content, and sex. We detected approximately 23,266 significant high-quality Single Nucleotide Polymorphisms (SNPs), establishing associations between markers and traits. The population structure analysis revealed that Iranian cannabis plants fall into five distinct groups. Additionally, a comparison with global data suggested that the Iranian populations is distinctive and generally closer to marijuana than to hemp, with some populations showing a closer affinity to hemp. The GWAS identified novel genetic loci associated with sex, yield, and chemotype traits in cannabis, which had not been previously reported.

Conclusion
The study's findings highlight the distinct genetic structure of Iranian Cannabis populations. The identification of novel genetic loci associated with important traits suggests potential targets for future breeding programs. This research underscores the value of the Iranian cannabis germplasm as a resource for breeding and selection efforts aimed at improving Cannabis for various uses.
Health-related quality of life in hypertensive patients with chronic kidney disease in low and middle-income countries
Authors: Wulandari Wening , Zakiyah Neily , Rahayu Cherry , Puspitasari Irma M. , Suwantika Auliya A. 
Published: January 2025

Abstract
Hypertension and chronic kidney disease (CKD) are interconnected conditions that can significantly affect a person’s health-related quality of life (HRQoL). In low- and middle-income countries (LMICs), this disease burden is heightened due to limited health resources and socio-economic challenges. Based on the available literature, this narrative review aims to discuss the HRQoL of hypertensive patients with CKD in LMICs by identifying the current challenges and providing insights into the strategic potential to improve patient’s quality of life. This review reveals that the hypertensive population with CKD has a much lower HRQoL than the general population. Various factors, including physical limitations, comorbidities, psychological barriers, logistical challenges, and social support, can influence HRQoL. Limited access to health care, inadequate resources, and a lack of skilled personnel in LMICs further exacerbate these individual challenges. The economic impact of decreased work productivity and increased health costs adds to the disease burden. Improved health access, effective self-management strategies, and social support are needed to improve HRQoL in hypertensive patients with CKD.
Medication adherence and blood pressure control in treated hypertensive patients: first follow-up findings from the PREDIcT-HTN study in Northern Bangladesh
Authors: Hossain Ahmed , Ahsan Gias Uddin , Hossain Mohammad Zakir , Hossain Mohammad Anwar , Sutradhar Probal , Alam Sarowar-E. , Sultana Zeeba Zahra , Hijazi Heba , Rahman Syed Azizur , Alameddine Mohamad 
Published: January 2025

Abstract

Introduction
Adherence to antihypertensive medication is crucial to control blood pressure (BP) and hypertension management outcomes. In Bangladesh, as in many other countries, poor adherence to medication represents a challenge to effective hypertension management. This study aims to investigate the prevalence and relationship between medication adherence and BP management among hypertensive patients in Bangladesh.

Methods
The PREDIcT-HTN study in Northern Bangladesh aims to evaluate major adverse clinical events in treated hypertensive patients. The study involves 2643 hypertensive patients from a medical center, with data collected through baseline information and yearly follow-ups until 2025. The first follow-up visit was conducted between January and March 2021. Following the 2020 ISH-global hypertension guideline, patients were classified as having controlled BP, grade-I, or grade-II uncontrolled BP. Patients were divided into three groups (good, moderate, and poor) based on their 9-item Hill-Bone medication adherence scale. A multinomial regression analysis was conducted to identify the association between medication adherence and BP control after adjusting potential confounders.

Results
Analysis of 2276 hypertensive patients (mean age 51.31 ± 11.58 years) revealed that 36.1% had grade-I and 24.2% had grade-II uncontrolled hypertension. Most patients (78%) displayed moderate adherence, and 15% showed poor medication adherence. Certain patient subgroups had higher rates of poor adherence: females (17.1%) compared to males (12.2%), rural residents (22.4%) compared to city-dwellers (12.2%), and newly diagnosed patients (17.2%) compared to those diagnosed 2–5 years earlier (12.6%). Multivariable analysis found a strong association between medication adherence and BP control. Compared to poor adherence, moderate adherence (relative risk ratio (RRR):0.50, 95%CI:0.36–0.68) and good adherence (RRR:0.56, 95%CI:0.35–0.91) were associated with better control. Increasing age, rural living, and uncontrolled hypertension were also linked. Comorbidities worsened BP control, and managing multiple medications contributed to poor adherence and grade-II hypertension in patients.

Conclusion
The high prevalence of uncontrolled hypertension in Bangladesh underscores the need for improved treatment strategies. Addressing medication adherence is essential for better BP control, with particular attention needed for women, rural residents, and newly diagnosed individuals. A comprehensive approach is warranted, including strategies to enhance adherence, early diagnosis, personalized treatment, and simplified medication regimens. These efforts align with the UN's 2030 SDGs, emphasizing targeted interventions for equitable healthcare access and outcomes.