bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paper‐Based Hydroelectric Generators for Water Evaporation‐Induced Electricity Generation
Authors: Zhang Jingjing , Cui Peng , Wang Jingjing , Meng Huan , Ge Ying , Feng Can , Liu Huimin , Meng Yao , Zhou Zunkang , Xuan Ningning , Zhang Bao , Cheng Gang , Du Zuliang 
Published: September 2023

AbstractThe research presented in this paper introduces a novel environmental energy‐harvesting technology that harnesses electricity from the evaporation of water using porous structural materials. Specifically, a strategy employing paper‐based hydroelectric generators (p‐HEGs) is proposed to capture the energy produced during water evaporation and convert it into usable electricity. The p‐HEGs offer several advantages, including simplicity in fabrication, low cost, and reusability. To evaluate their effectiveness, the water evaporation‐induced electrical output performance of four different p‐HEGs are compared. Among the variants tested, the p‐HEG combining wood pulp and polyester fiber exhibits the best output performance. At room temperature, this particular p‐HEG generates a short‐circuit current and open‐circuit voltage of ≈0.4 µA and 0.3 V, respectively, thereby demonstrating excellent electrical stability. Furthermore, the electrical current and voltage generated by the p‐HEG through water evaporation are able to power an LED light, both individually and in series and parallel connections. This study delves into the potential of electricity harvesting from water evaporation and establishes it as a viable method for renewable energy applications.
Analysis of 60 patients with relapsed or refractory T‐cell acute lymphoblastic leukemia and T‐cell lymphoblastic lymphoma treated with CD7‐targeted chimeric antigen receptor‐T cell therapy
Authors: Zhang Xian , Yang Junfang , Li Jingjing , Qiu Liyuan , Zhang Jianping , Lu Yue , Zhao Yan‐li , Jin David , Li Jianqiang , Lu Peihua 
Published: September 2023

AbstractWhile the use of chimeric antigen receptor‐T (CAR‐T) therapy for T‐cell malignancies is in the early stage of clinical trials, it exhibits substantial potential to offer long‐term remission for patients with refractory/relapsed (R/R) T‐cell malignancies. In our phase I/II clinical trials, 65 pediatric and adult patients with R/R T‐cell acute lymphoblastic leukemia and lymphoblastic lymphoma (T‐ALL/LBL) were enrolled (NCT04572308 and NCT04916860). Of these, 60 participants (T‐ALL 35, T‐LBL 25) received a single dose of naturally selected anti‐CD7 CAR (NS7CAR) T cells at three levels: a low dose (5 × 105/kg), a medium dose (1 to 1.5 × 106/kg), and a high dose (2 × 106/kg). On day 28, 94.4% of patients achieved deep complete remission (CR) in bone marrow. Among the 32 patients with extramedullary disease, 78.1% showed response, with 56.3% in CR and 21.9% in partial remission. The 2‐year overall survival and progression‐free survival (PFS) were 63.5% (95% CI 47.7–79.4) and 53.7% (95% CI, 38.9–68.6), with no difference between pediatric and adult patients. PFS was significantly higher among the 37 CR patients who proceeded with consolidation transplant than the 10 patients who did not with 1‐year PFS 67.2% (95% CI 51.9–82.4) versus 15.0% (95% CI 0–40.2), p < .0001. Of the 10 CR patients without transplants, eight relapsed, while two sustained CR on day 128, and day 180, respectively. Cytokine release syndrome occurred in 91.7% of patients (grade 1/2 in 80.0%, grade 3/4 in 11.7%) and 5% of patients had neurotoxicity. NS7CAR‐T therapy is effective in treating R/R T‐ALL/LBL patients with promising PFS while maintaining a manageable safety profile.
Men's household water fetching in India: Gender inequity is associated with greater responsibility and related risks
Authors: Brewis Alexandra , Choudhary Neetu , Wutich Amber 
Published: September 2023

AbstractIntroductionHousehold water fetching elevates physical and emotional harms, and these are generally assumed to accrue to women due to gendered labor assignments. But even in cases like India where fetching remains a highly feminized task, there are households where the primary responsibility is assumed by men.MethodsWe test the proposition that men's responsibility for water fetching is predicted by greater gender equity, reflected in measures of wives' empowerment. We used an extremely large, nationally representative Demographic and Health Survey dataset from India (2019–2020), narrowed to only households in which spouses co‐reside with off‐plot water sources (N = 10 616), and applying a multinomial regression approach.ResultsIn >20% of households, men are the primary fetchers. They are more likely to have primary responsibility when water is more distant, privately purchased, or transported by vehicle. Contrary to predictions, men assume greater responsibility for household water fetching as their wives' empowerment measuresdecreaseand when they want to control their movement.ConclusionMarried men in India sometimes assume responsibility for water fetching, but this is not explained by greater household gender equity. The findings also suggest that when men are responsible for fetching they have heightened risk of some forms of physical trauma but less relative psychological harm. Detailing why men fetch water matters for identifying and mitigating the physical and emotion harms of bearing responsibility for water labor, with implications for how gender should be conceptualized in water interventions intending to improve health and well‐being.
Synthesis and characterization of biodegradable and photocrosslinkable multi‐block poly(ether‐ester): Molecular‐weight and component of the polyethylene glycol segment dependence
Authors: Cai Chaoyi , Chen Zhifan , Ye Shufen , Zhang Rong , Pan Xiaodi , Yang Rong , Li Jinchun 
Published: September 2023

AbstractThis work synthesized a series of biodegradable thermoplastic elastomer PBSFG via an esterification polycondensation reaction. The influence of the soft segment PEG molecular weight and component on the thermal behavior, mechanical property, and degradation performance of PBSFG were investigated. The results showed that the PEG component plays a major part in the properties of PBSFG. Upon reaching a PEG component concentration of 40% within PBSFG, the yielding phenomenon becomes imperceptible on the stress–strain curves, signifying the onset of a plastic‐to‐elastomer transition. In the case of PBSFG40‐6k, a remarkable tensile strength of 23.5 MPa and an elongation at break measuring 576% were achieved, thereby displaying tensile properties on par with those of PBAT. Thanks to the unsaturated structure, the mechanical properties of PBSFG can be enhanced by UV irradiation. Finally, Candida cylindracea lipase catalytic degradation experiments showed that PBSFG is a biodegradable polyester, which is beneficial in reducing environmental plastic pollution.
Low‐cost and high‐performance poly(butylene adipate‐co‐terephthalate)/thermoplastic starch blends prepared by an eccentric rotor extruder: Morphology, rheological behavior, thermal and mechanical properties
Authors: Xu Mohong , Li Fengqing , Yan Xiangyu , Li Jiqian , Jia Ligeng , Liu Zhigang , He Hezhi , Li Yi , Zhu Zhiwen 
Published: September 2023

AbstractDue to similar processing and mechanical properties, poly(butylene adipate‐co‐terephthalate) (PBAT) is expected to be a fully‐biodegradable alternative to low‐density polyethylene (LDPE) packaging films, thereby alleviating environmental pollution caused by waste packaging films. However, the higher price of PBAT limits its large‐scale practical application in the packaging field. Blending with thermoplastic starch (TPS) to prepare PBAT/TPS blends can reduce the cost. In this work, the PBAT/TPS blends with different compositions were prepared using a novel eccentric rotor extruder dominated by an extensional flow field. With increasing the TPS content, a transition from the sea‐island phase structure to the bicontinuous phase structure occurred near the composition ratio of 50/50. Moreover, the dynamic mechanical analysis results showed that the compatibility between PBAT and TPS first improved and then deteriorated as the TPS content increased. As a result, the elongation at break first decreased slightly from ~1585% for the PBAT/TPS(90/10) blend to ~1263% for the PBAT/TPS(70/30) blend and dropped sharply to ~130% for the PBAT/TPS(40/60) blend. The knowledge obtained from this study will help us further understand the effect of the TPS phase on the micro‐morphology and macro‐properties of the PBAT/TPS blends, which is important for the future preparation of high‐performance PBAT/TPS blends.
Anisotropic properties of additively manufactured concrete elements
Authors: Lindner Marco , Gliniorz Ralf , Funke Henrik , Gelbrich Sandra 
Published: September 2023

AbstractRobotic concrete extrusion is a novel additive manufacturing process (three‐dimensional concrete printing) and is part of a continuously digitally controlled value chain. According to the state of the art, concrete is considered to be an isotropic material due to the manufacturing process. However, for the additive manufacturing process, the isotropic approach has to be reconsidered due to the layered structure. It can be assumed that due to the layered structure, the material properties vary depending on the deposition direction and the geometry of the layers. The aim of the work was to record the material‐technical characteristics of extruded elements manufactured according to standards in comparison with concrete recipes. Process‐related influences on the mechanical parameters of additively manufactured concrete elements were examined and evaluated in more detail. Based on the findings obtained, the dimensioning, design and measurement of components can be carried out and thus guidelines for components can be derived. With these derived guidelines, the material utilization and economic efficiency can be improved.
Are people with autism prosopagnosic?
Authors: Kamensek Todd , Susilo Tirta , Iarocci Grace , Oruc Ipek 
Published: September 2023

AbstractDifficulties in various face processing tasks have been well documented in autism spectrum disorder (ASD). Several meta‐analyses and numerous case–control studies have indicated that this population experiences a moderate degree of impairment, with a small percentage of studies failing to detect any impairment. One possible account of this mixed pattern of findings is heterogeneity in face processing abilities stemming from the presence of a subpopulation of prosopagnosic individuals with ASD alongside those with normal face processing skills. Samples randomly drawn from such a population, especially relatively smaller ones, would vary in the proportion of participants with prosopagnosia, resulting in a wide range of group‐level deficits from mild (or none) to severe across studies. We test this prosopagnosic subpopulation hypothesis by examining three groups of participants: adults with ASD, adults with developmental prosopagnosia (DP), and a comparison group. Our results show that the prosopagnosic subpopulation hypothesis does not account for the face impairments in the broader autism spectrum. ASD observers show a continuous and graded, rather than categorical, heterogeneity that span a range of face processing skills including many with mild to moderate deficits, inconsistent with a prosopagnosic subtype account. We suggest that pathogenic origins of face deficits for at least some with ASD differ from those of DP.
CITIES: Clinical trials with intercurrent events simulator
Authors: Wahab Ahmad Hakeem Abdul , Qu Yongming , Michiels Hege , Luo Junxiang , Zhuang Run , McDaniel Dominique , Xi Dong , Polverejan Elena , Gilbert Steven , Ruberg Stephen , Sabbaghi Arman 
Published: September 2023

AbstractAlthough clinical trials are often designed with randomization and well‐controlled protocols, complications will inevitably arise in the presence of intercurrent events (ICEs) such as treatment discontinuation. These can lead to missing outcome data and possibly confounding causal inference when the missingness is a function of a latent stratification of patients defined by intermediate outcomes. The pharmaceutical industry has been focused on developing new methods that can yield pertinent causal inferences in trials with ICEs. However, it is difficult to compare the properties of different methods developed in this endeavor as real‐life clinical trial data cannot be easily shared to provide benchmark data sets. Furthermore, different methods consider distinct assumptions for the underlying data‐generating mechanisms, and simulation studies often are customized to specific situations or methods. We develop a novel, general simulation model and corresponding Shiny application in R for clinical trials with ICEs, aptly named the Clinical Trials with Intercurrent Events Simulator (CITIES). It is formulated under the Rubin Causal Model where the considered treatment effects account for ICEs in clinical trials with repeated measures. CITIES facilitates the effective generation of data that resemble real‐life clinical trials with respect to their reported summary statistics, without requiring the use of the original trial data. We illustrate the utility of CITIES via two case studies involving real‐life clinical trials that demonstrate how CITIES provides a comprehensive tool for practitioners in the pharmaceutical industry to compare methods for the analysis of clinical trials with ICEs on identical, benchmark settings that resemble real‐life trials.
A joint Bayesian framework for missing data and measurement error using integrated nested Laplace approximations
Authors: Skarstein Emma , Martino Sara , Muff Stefanie 
Published: September 2023

AbstractMeasurement error (ME) and missing values in covariates are often unavoidable in disciplines that deal with data, and both problems have separately received considerable attention during the past decades. However, while most researchers are familiar with methods for treating missing data, accounting for ME in covariates of regression models is less common. In addition, ME and missing data are typically treated as two separate problems, despite practical and theoretical similarities. Here, we exploit the fact that missing data in a continuous covariate is an extreme case of classical ME, allowing us to use existing methodology that accounts for ME via a Bayesian framework that employs integrated nested Laplace approximations (INLA) and thus to simultaneously account for both ME and missing data in the same covariate. As a useful by‐product, we present an approach to handle missing data in INLA since this corresponds to the special case when no ME is present. In addition, we show how to account for Berkson ME in the same framework. In its broadest generality, the proposed joint Bayesian framework can thus account for Berkson ME, classical ME, and missing data, or any combination of these in the same or different continuous covariates of the family of regression models that are feasible with INLA. The approach is exemplified using both simulated and real data. We provide extensive and fully reproducible Supporting Information with thoroughly documented examples using R‐INLA and inlabru.
Sensitive spectrofluorimetric determination of the prokinetic drug prucalopride succinate based on supramolecular aggregation approach with evaluation of method greenness: application to content uniformity test
Authors: Derayea Sayed M. , Mohammed Fatma F. , Badr El‐Din Khalid M. 
Published: September 2023

AbstractThe prokinetic drug, prucalopride (PCP) succinate, was determined using a new spectrofluorimetric approach with a highly sensitive, rapid, and simple procedure. The method exploited the enhancement of the inherent native fluorescence of PCP by micellar aggregation with sodium lauryl sulfate (SLS) as an anionic surfactant. Different factors that could affect the fluorescence intensity were carefully studied in order to achieve the maximal fluorescence signal. Measurement of the enhanced fluorescence was done at 354 nm after the excitation at 276 nm. The fluorescence intensity–concentration plot was rectilinear in the concentration range of 50–600 ng/ml with detection and quantitation limits of 13.9 and 42.1 ng/ml, respectively. The method underwent validation according to the International Council for Harmonisation criteria in order to assess its analytical performance, and promising results were achieved that proved the validity and reliability of the method. Furthermore, the method was employed effectively for the analysis of the cited drug in commercial pharmaceutical tablets.
Identification of an Alepterolic Acid Derivative as a Potent Anti‐Breast‐Cancer Agent via Inhibition of the Akt/p70S6K Signaling Pathway
Authors: Wang Nina , Zhang Lei , Yu Junjie , Chang Kaili , Fan Minghui , Liu Zi , Ma Liang , Cao Jianguo , Huang Guozheng 
Published: September 2023

AbstractAlepterolic acid is a diterpene occurring in the fern Aleuritopteris argentea with potential biological activity that warrants further structural modification. In the present work, sixteen alepterolic acid derivatives were synthesized and evaluated for their anticancer activities. Among them, N‐[m‐(trifluoromethoxy)phenyl] alepterolamide displayed comparable activity (IC50=4.20±0.21 μM) in MCF‐7 cells. Moreover, mechanistic investigations indicated this compound was significantly capable of diminishing cell proliferation and viability of MCF‐7 cells. After treatment with N‐[m‐(trifluoromethoxy)phenyl] alepterolamide, a significant increase in cleaved caspase‐9, cleaved caspase‐3, cleaved poly (ADP‐ribose) polymerase (PARP) and Bax/Bcl2 ratio were observed in MCF‐7 cells, leading to caspase‐dependent apoptotic pathways. Further studies showed this compound promoted cellular apoptosis and inhibited migration in MCF‐7 cells via modulation of the Akt/p70S6K signaling pathway. All these results revealed the potential of N‐[m‐(trifluoromethoxy)phenyl] alepterolamide as an appealing therapeutic drug candidate for breast cancer.
Noninvasive diagnosis of Ascaris lumbricoides in the common bile duct: A pediatric case report of acute pancreatitis
Authors: Samir Komal , Subash Tushar , Subash Arun , Bilal Hammad , Shah Hussain Haider , Dave Tirth 
Published: September 2023

Key Clinical MessageThis case report highlights the importance of considering parasitic infections, particularly Ascaris lumbricoides, as a possible cause of acute pancreatitis in children, especially in endemic regions. Noninvasive imaging techniques, such as ultrasonography, can play a crucial role in the early detection and diagnosis of this unusual presentation. Timely administration of anthelmintic therapy led to the resolution of symptoms and prevented the need for invasive procedures. Healthcare providers should be vigilant about the diverse clinical manifestations of ascariasis, and regular deworming programs and health education are essential in minimizing the burden of this neglected tropical disease among children.AbstractAscariasis is a common public health problem globally but it is more prevalent in school‐age children and it often goes undiagnosed, leading to severe complications. The purpose of this report is to spread awareness of its unusual presentation and how to judiciously use noninvasive approaches for its diagnosis. We present a case of a 10‐year‐old girl that was presented in pediatric emergency with gradually worsening epigastric pain. Initial lab work‐up showed elevated pancreatic enzymes which lead to the diagnosis of acute pancreatitis. The patient was managed in the line of acute pancreatitis and with further evaluation by imaging techniques such as ultrasound and CT‐scan abdomen, Ascaris lumbricoides (A. lumbricoides) was visualized. She was then treated with prophylactic antibiotics and antiparasitic medications, which resolved her symptoms and the child responded to the treatment. In children, parasites should be considered as a cause of acute pancreatitis by clinicians, especially in low‐income countries, and before performing invasive procedures, noninvasive approaches should be considered as an initial option. This can save the patient from multiple invasive procedure and its severe complications.
Charge Transfer in Be−Ru Compounds
Authors: Agnarelli Laura , Prots Yurii , Krnel Mitja , Svanidze Eteri , König Markus , Schmidt Marcus , Burkhardt Ulrich , Leithe‐Jasper Andreas , Grin Yuri 
Published: September 2023

AbstractDuring the investigation of the binary system Be−Ru two new phases – Be7Ru4and Be12Ru7– with similar compositions (63.6 at. % Be and 63.2 at. % Be, respectively), are discovered. They both represent new structural prototypes. The phases are located between Be2Ru (Fe2P‐type structure) and Be3Ru2(U3Si2‐type structure) in the phase diagram. This explains why their crystal structures, solved and refined from single crystal X‐ray diffraction data, are described as 2D intergrowth of Fe2P and U3Si2motives. The calculated electronic density of stats (DOS) reveals pronounced minima in the vicinity of the Fermi level for both compounds. Position‐space analysis of chemical bonding exhibits the formation of three‐ and four‐atomic polar bonds, involving both, Ru and Be, atoms, and a strong charge transfer from Be to the more electronegative Ru.
Intramolecular Electron Transfer in Multi‐Redox Systems Based on Cyclic [3]Spirobifluorenylene Compound**
Authors: Imai Tomoya , Sakamaki Daisuke , Aoyagi Shinobu , Amaya Toru 
Published: September 2023

AbstractCyclic [3]spirobifluorenylene with bulky alkyl groups at the ends (1) was designed and synthesized to investigate the electron transfer phenomena in a π‐conjugated system including orthogonal π‐conjugated chains. The three bifluorenyl units in 1 are conjugated to each other via spiro‐conjugation, resulting in the splitting of the HOMO levels to a small extent. Therefore, the SOMO‐HOMO gap of the radical cation species is small, which is considered to allow the facile intramolecular electron transfer. The electronic properties of 1 and its partial structures were characterized by absorption and fluorescence measurements and electrochemical analysis. From the electrochemical oxidation, the interchain Coulombic repulsion was observed. In the TD‐DFT calculations for the radical cation species of 1, the geometry‐featured interchain electronic transitions were visualized by NTO calculations. The radical cation species of 1 generated by chemical oxidation with SbCl5 exhibited a broadened and lower‐energy NIR absorption band exceeding 2000 nm. Considering the results of the TD‐DFT calculations, the NIR band of the radical cation of 1 was attributed to the intramolecular electron transfer processes among the bifluorenyl units in the macrocycle. ESR experiments also indicated the delocalization of a spin of 1⋅+ in the whole molecule via hole hopping in the ESR time scale at room temperature. This work demonstrates the usefulness of spiro‐conjugation as a bridging unit in molecular wires to facilitate smooth electron transfer.