bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of area‐level socioeconomic disadvantage in racial disparities in cancer incidence in metropolitan Detroit
Authors: Purrington Kristen S. , Hastert Theresa A. , Madhav K. C. , Nair Mrudula , Snider Natalie , Ruterbusch Julie J. , Schwartz Ann G. , Stoffel Elena M. , Peters Edward S. , Rozek Laura S. 
Published: May 2023

AbstractBackgroundNeighborhood deprivation is associated with both race and cancer incidence, but there is a need to better understand the effect of structural inequities on racial cancer disparities. The goal of this analysis was to evaluate the relationship between a comprehensive measure of neighborhood‐level social disadvantage and cancer incidence within the racially diverse population of metropolitan Detroit.MethodsWe estimated breast, colorectal, lung, and prostate cancer incidence rates using Metropolitan Detroit Cancer Surveillance System and US decennial census data. Neighborhood socioeconomic disadvantage was measured by the Area Deprivation Index (ADI) using Census Bureau's American Community Survey data at the Public Use Microdata Areas (PUMA) level. Associations between ADI at time of diagnosis and cancer incidence were estimated using Poisson mixed‐effects models adjusting for age and sex. Attenuation of race‐incidence associations by ADI was quantified using the “mediation” package in R.ResultsADI was inversely associated with incidence of breast cancer for both non‐Hispanic White (NHW) and non‐Hispanic Black (NHB) women (NHW: per‐quartile RR = 0.92, 95% CI 0.88–0.96; NHB: per‐quartile RR = 0.94, 95% CI 0.91–0.98) and with prostate cancer incidence only for NHW men (per‐quartile RR = 0.94, 95% CI 0.90–0.97). ADI was positively associated with incidence of lung cancer for NHWs and NHBs (NHW: per‐quartile RR = 1.12, 95% CI 1.04–1.21; NHB: per‐quartile RR = 1.37, 95% CI 1.25–1.51) and incidence of colorectal cancer (CRC) only among NHBs (per‐quartile RR = 1.11, 95% CI 1.02–1.21). ADI significantly attenuated the relationship between race and hormone receptor positive, HER2‐negative breast cancer (proportion attenuated = 8.5%, 95% CI 4.1–16.6%) and CRC cancer (proportion attenuated = 7.3%, 95% CI 3.7 to 12.8%), and there was a significant interaction between race and ADI for lung (interaction RR = 1.22, p < 0.0001) and prostate cancer (interaction RR = 1.09, p = 0.00092).ConclusionsArea‐level socioeconomic disadvantage is associated with risk of common cancers in a racially diverse population and plays a role in racial differences in cancer incidence.
Chemical Tools for Studying Phosphohistidine: Generation of Selective τ‐Phosphohistidine and π‐Phosphohistidine Antibodies**
Authors: Makwana Mehul V. , dos Santos Souza Cleide , Pickup Barry T. , Thompson Mark J. , Lomada Santosh K. , Feng Yuxi , Wieland Thomas , Jackson Richard F. W. , Muimo Richmond 
Published: May 2023

AbstractNonhydrolysable stable analogues of τ‐phosphohistidine (τ‐pHis) and π‐pHis have been designed, aided by electrostatic surface potential calculations, and subsequently synthesized. The τ‐pHis and π‐pHis analogues (phosphopyrazole 8 and pyridyl amino amide 13, respectively) were used as haptens to generate pHis polyclonal antibodies. Both τ‐pHis and π‐pHis conjugates in the form of BSA‐glutaraldehyde‐τ‐pHis and BSA‐glutaraldehyde‐π‐pHis were synthesized and characterized by 31P NMR spectroscopy. Commercially available τ‐pHis (SC56‐2) and π‐pHis (SC1‐1; SC50‐3) monoclonal antibodies were used to show that the BSA−G‐τ‐pHis and BSA−G‐π‐pHis conjugates could be used to assess the selectivity of pHis antibodies in a competitive ELISA. Subsequently, the selectivity of the pHis antibodies generated by using phosphopyrazole 8 and pyridyl amino amide 13 as haptens was assessed by competitive ELISA against His, pSer, pThr, pTyr, τ‐pHis and π‐pHis. Antibodies generated by using phosphopyrazole 8 as a hapten were found to be selective for τ‐pHis, and antibodies generated by using pyridyl amino amide 13 were found to be selective for π‐pHis. Both τ‐ and π‐pHis antibodies were shown to be effective in immunological experiments, including ELISA, western blot, and immunofluorescence. The τ‐pHis antibody was also shown to be useful in the immunoprecipitation of proteins containing pHis.
Stable Binding of Full‐Length Chemerin Is Driven by Negative Charges in the CMKLR1 N Terminus
Authors: Kretschmer Kevin , Zellmann Tristan , Mörl Karin , Beck‐Sickinger Annette G. 
Published: May 2023

AbstractThe adipokine chemerin is the endogenous ligand of the chemokine‐like receptor 1 (CMKLR1), a member of the family of G protein‐coupled receptors (GPCRs). This protein ligand plays an important role in obesity and inflammatory processes. Stable receptor–ligand interactions are highly relevant for its different physiological effects such as the migration of immune cells towards sites of inflammation. Here, we demonstrate that negative charges in the CMKLR1 N terminus are involved in the formation of strong contacts with a specific positively charged patch at the surface of full‐length chemerin, which is absent in the short nonapeptide agonist chemerin‐9, thus explaining its reduced affinity. Using receptor chimera of G protein‐coupled receptor 1 (GPR1) and CMKLR1, we were able to identify the residues of this interaction and its relevance for stable full‐length chemerin binding. This could help to develop more potent ligands for the treatment of inflammation‐related diseases.
Micelle‐Mediated Sonogashira Coupling for DNA‐Encoded Library Synthesis
Authors: Graham Jessica S. , Stanway‐Gordon Harriet A. , Waring Michael J. 
Published: May 2023

AbstractDNA‐Encoded Libraries (DELs) are becoming widely established as a hit identification strategy for drug discovery campaigns. Their successful application relies on the availability and efficiency of the reactions that can be carried out on DNA. These reactions should proceed with high conversion to the desired product and have a broad substrate scope to synthesise chemically diverse and drug‐like DELs. The Sonogashira coupling provides a unique means of coupling an sp‐hybridized carbon centre to an aryl halide and methods to achieve this reaction on DNA are highly desirable. We report the application of our micellar technology for on‐DNA chemistry to the Sonogashira reaction. This method gives highly efficient conversions for the coupling of (hetero)aromatic and aliphatic alkynes to (hetero)aryl iodides and bromides allowing the preparation of highly diverse DELs.
Direct C7‐H Arylation of Pyrazolo[1,5‐a]azines with Aryl Chlorides
Authors: Nguyen Thanh V. Q. 
Published: May 2023

AbstractC7‐Arylated pyrazolo[1,5‐a]azines are important structural motifs with profound applications in drug and material research. Here, we report a general and straighforward synthesis of these bi(hetero)aryls via palladium‐catalyzed direct C−H arylation, employing low‐cost and abundant (hetero)aryl chlorides as the aryl source. The catalytic system is robust and covers a wide substrate scope regarding heteroarenes as well as (hetero)aryl chlorides, with possible extension to the C−H arylation of [1,2,4]triazolo[1,5‐a]pyrimidines. This study also presents a rare example of using (hetero)aryl chlorides for the direct C−H arylation of six‐membered heteroarenes.
Chiral Josephson effect in double layers: The role of particle–hole duality
Authors: Ziegler Klaus 
Published: May 2023

AbstractThe Josephson effect of inter‐layer s‐wave pairing in a double layer of two chiral metals with Josephson junctions along the direction is considered. Starting from the Bogoliubov de Gennes equations of electron–electron and electron–hole double layers, we employ the duality transformation between the two systems to determine the relation of the zero‐energy quasiparticle modes at a Josephson junction in both systems. The appearance of an exceptional point at zero energy is observed, where the four‐dimensional eigenspace coalesces to a two‐dimensional eigenspace. In the second part of the article, the coupling of the quasiparticle currents and the supercurrent is studied. The coupling is based on the quasiparticle charge conservation in the form of a continuity equation. Although the quasiparticle modes differ between the electron–electron and the electron–hole double layers, their corresponding currents are the same.
Evaluation of microalgae on preventing bone loss in C57BL/6J mice induced by hindlimb suspension
Authors: Zou Yingying , Zhang Jian , Yan Bowen , Zhang Nana , Zhao Jianxin , Zhang Hao , Chen Wei , Fan Daming 
Published: May 2023

AbstractBone loss caused by microgravity severely damages the health of astronauts; however, no effective countermeasures exist. Microalgae are microscopic algae rich in protein, polysaccharide, and other nutrients, which can provide astronauts with safe food and oxygen supply in the space ecosystem. Recent studies have demonstrated that microalgae can potentially reduce bone loss in primary osteoporosis. Here, a hindlimb suspension (HLS) mouse (C57BL/6J) model was used to investigate the potential effects of five different microalgae in preventing microgravity‐induced bone loss. The results showed that long‐term administration of 300 mg/kg body weight/day Spirulina platensis (SP) significantly reduced bone loss and increased trabecular number and bone strength. In addition, mice in the HLS group also exhibited disordered gut microbiota with increased Firmicutes/Bacteroidetes, decreased fecal short‐chain fatty acids levels, and increased levels of colonic proinflammatory cytokines interleukin‐6 and tumor necrosis factor‐α. To a certain extent, SP reduced these changes and maintained homeostasis of the intestinal environment. These results suggest that SP has a potential enhancing effect on resistance to bone loss in HLS mice.
Phytochemicals and bioactive compounds effective against acute myeloid leukemia: A systematic review
Authors: Egbuna Chukwuebuka , Patrick‐Iwuanyanwu Kingsley C. , Onyeike Eugene N. , Khan Johra , Palai Santwana , Patel Sandip B. , Parmar Vijaykumar K. , Kushwaha Garima , Singh Omkar , Jeevanandam Jaison , Kumarasamy Suresh , Uche Chukwuemelie Zedech , Narayanan Mathiyazhagan , Rudrapal Mithun , Odoh Uchenna , Chikeokwu Ikenna , Găman Mihnea‐Alexandru , Saravanan Kaliyaperumal , Ifemeje Jonathan C. , Ezzat Shahira M. , Olisah Michael C. , Chikwendu Chukwudi Jude , Adedokun Kamoru A. , Imodoye Sikiru O. , Bello Ibrahim O. , Twinomuhwezi Hannington , Awuchi Chinaza Godswill 
Published: May 2023

AbstractThis systematic review identified various bioactive compounds which have the potential to serve as novel drugs or leads against acute myeloid leukemia. Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy that arises from the dysregulation of cell differentiation, proliferation, and cell death. The risk factors associated with the onset of AML include long‐term exposure to radiation and chemicals such as benzene, smoking, genetic disorders, blood disorders, advancement in age, and others. Although novel strategies to manage AML, including a refinement of the conventional chemotherapy regimens, hypomethylating agents, and molecular targeted drugs, have been developed in recent years, resistance and relapse remain the main clinical problems. In this study, three databases, PubMed/MEDLINE, ScienceDirect, and Google Scholar, were systematically searched to identify various bioactive compounds with antileukemic properties. A total of 518 articles were identified, out of which 59 were viewed as eligible for the current report. From the data extracted, over 60 bioactive compounds were identified and divided into five major groups: flavonoids, alkaloids, organosulfur compounds, terpenes, and terpenoids, and other known and emerging bioactive compounds. The mechanism of actions of the analyzed individual bioactive molecules differs remarkably and includes disrupting chromatin structure, upregulating the synthesis of certain DNA repair proteins, inducing cell cycle arrest and apoptosis, and inhibiting/regulating Hsp90 activities, DNA methyltransferase 1, and histone deacetylase 1.
Relationship between fine/gross motor skills and language and math development in Colombian Caribbean children: A study in Barranquilla
Authors: Rodríguez‐Guerrero Yulmis Isabel , Gil‐Madrona Pedro , Pilar León María , Vásquez‐Cruz Adrián Eduardo 
Published: May 2023

AbstractLiterature suggests that motor skills are associated with other areas of development or domains, such as language and math, especially at early ages. These results are mainly based on studies developed in medium‐to‐high sociocultural contexts. Thus, this study was conducted in a medium‐to‐low‐income area. The aim was to know the 4–5 years old children's motor development (both fine and gross motor skills), and its relation to language and mathematical development. A total of 219 Colombian Caribbean children (105 boys and 114 girls) aged 4 and 5 years participated in this study. Results revealed higher motor skills among girls, although differences by gender were not notable. Positive and significant correlations were found between motor skills and language and mathematical skills, although most of the correlations were weak or moderate. Also, it was observed that fine motor skills were less related to language or mathematical development in comparison with gross motor skills, especially among boys. These results suggest that among Colombian Caribbean children gross motor skills could have a higher influence on the development and acquisition of some language and mathematical skills in comparison with fine motor skills.
Postoperative management of FIGO 2018 stage IIA1 cervical squamous cell carcinoma with only one intermediate‐risk factor: Is radiotherapy needed?
Authors: Liu Yunlu , He Junshen , Liu Ping , Chen Chunlin 
Published: May 2023

AbstractObjectiveTo investigate whether postoperative radiotherapy is required for FIGO 2018 stage IIA1 cervical squamous cell carcinoma patients with only one intermediate‐risk factor.MethodsThis was a multicenter retrospective study. The selected patients were classified into no postoperative adjuvant therapy and postoperative radiotherapy groups. The 5‐year overall survival (OS) and disease‐free survival (DFS) rates were compared.ResultsIn total, 159 patients with no postoperative adjuvant therapy and 179 patients with postoperative radiotherapy were included, with the former group showing a lower OS but no difference in DFS. No postoperative adjuvant therapy was an independent risk factor for patient mortality. Patients were also stratified by tumor diameter: 56 patients had a tumor diameter ≤2 cm, comprising 32 patients with postoperative radiotherapy and 24 patients without (no between‐group difference was found); 272 patients had a tumor diameter >2 cm, comprising 122 patients with postoperative radiotherapy and 150 patients without, with the former group showing a higher OS, and no postoperative adjuvant therapy was an independent risk factor for patient mortality.ConclusionFor FIGO 2018 stage IIA1 cervical squamous cell carcinoma patients with only one intermediate‐risk factor and a tumor diameter >2 cm, postoperative radiotherapy is likely beneficial to improve prognosis.
Is prophylactic intraoperative abdominal aortic balloon occlusion beneficial in pregnancies with placenta previa and placenta accreta spectrum during cesarean section? A 5‐year retrospective study
Authors: Wang Zi‐Xuan , Zhao Yi‐Fan , Li Lin 
Published: May 2023

AbstractObjectiveTo assess whether prophylactic intraoperative abdominal aortic balloon occlusion (IAABO) is indeed beneficial in pregnancies with placenta previa (PP) and placenta accreta spectrum (PAS) during cesarean section.MethodsA retrospective case–control study included 251 pregnancies with PP and/or PAS. All enrolled patients were divided into a PP/PAS group, a PP + PAS group, and an IAABO group. The demographic characteristics and maternal and neonatal outcomes were compared.ResultsThere was no significant difference in blood loss and transfusion between the IAABO group and the PP + PAS group (P > 0.05). However, blood loss and red blood cell and fresh frozen plasma transfusion in the above two groups were significantly higher than in the PP/PAS group (P < 0.05). More pregnancies in the IAABO group had to undergo uterine artery embolization (29.2%) or hysterectomy (20.8%), and this percentage was significantly higher than that in the other two groups (P < 0.001). All neonatal characteristics did not show differences between the IAABO group and PP + PAS group (P > 0.05). IAABO led to femoral artery thrombosis in three cases and minor postoperative renal injury in one case.ConclusionIAABO only acted as a less important supporting technique during cesarean section. There was no evidence suggesting that IAABO could significantly control the massive hemorrhage in pregnancies with PP and PAS during cesarean delivery.
Comparison between the demographic shift clinical severity and outcome of the first two waves of COVID‐19 in pregnancy in a tertiary hospital in India
Authors: Lenin Audrin , Abraham Kavitha , David Liji Sarah , Tirkey Richa Sasmita , Mani Thenmozhi , Jasmine Sudha , Sathyendra Soumya 
Published: May 2023

AbstractObjectiveTo study and compare the maternal and neonatal outcomes of COVID‐19 in pregnancy during the two waves of the pandemic in India.MethodsThis observational, retrospective cohort study on pregnant women with SARS‐CoV‐2 infection was conducted in a 2700‐bed tertiary referral center in South India from March 1, 2020 to June 30 2021. The clinical presentation, severity, and maternal and neonatal outcomes of COVID‐19 were compared between the two waves.ResultsA total of 623 pregnant women tested positive for SARS‐CoV‐2 infection in our institute; 379 (60.8%) were diagnosed during the first wave and 244 (39.2%) in the second wave. Most of the affected women (81.1%) were in their third trimester. Maternal mortality rate was 823 per 100 000 live births. Composite maternal outcome (increasing requirement for ventilation, pulmonary embolism, disease progression) were more pronounced during the second wave (2.1% vs 6.1%). Between the two waves, both maternal (1 vs 3; P = 0.162) and perinatal (3.2% vs 6.7%; P = 0.065) deaths were higher during the second wave. The cesarean section rate was high during the first wave (48% vs 32.4%; P < 0.001). Preterm births were comparable between the two waves (19.5% vs 22%; P < 0.500).ConclusionThe women presented with more severe illness during the second wave of COVID‐19. There was higher perinatal mortality, but the maternal mortality was similar between the two waves.
ALDH2 promotes cancer stemness and metastasis in colorectal cancer through activating β‐catenin signaling
Authors: Wei Po‐Li , Prince G. M. Shazzad Hossain , Batzorig Uyanga , Huang Chien‐Yu , Chang Yu‐Jia 
Published: May 2023

AbstractColorectal cancer (CRC) is the primary cause of death from gastrointestinal cancers. Aldehyde dehydrogenase 2 (ALDH2), a crucial mitochondrial enzyme for the oxidative pathway of alcohol metabolism, plays a dual role in cancer progression. In some cancers, it is tumor suppressive; in others, it drives cancer progression. However, whether targeting ALDH2 has any therapeutic implications or prognostic value in CRC is still unclear. Here, we investigated the role of ALDH2 in CRC progression by targeting its enzymatic activity rather than gene expression. We found that inhibiting ALDH2 by CVT‐10216 and daidzein significantly decrease migration and stemness properties of both DLD‐1 and HCT 116 cells, whereas activating ALDH2 by Alda‐1 enhances migration rate. Concomitantly, ALDH2 inhibition by both CVT‐10216 and daidzein downregulates the mRNA levels of fibronectin, snail, twist, MMP7, CD44, c‐Myc, SOX2, and OCT‐4, which are oncogenic in the advanced stage of CRC. Furthermore, Gene Set Enrichment Analysis (GSEA) on ALDH2 co‐expressed genes from The Cancer Genome Atlas (TCGA) revealed that MYC target gene sets are upregulated. We found that ALDH2 inhibition decreased the nuclear protein levels of pGSK3β serine 9 and c‐Myc. This suggests that ALDH2 probably targets β‐catenin signaling in CRC cells. Together, our results demonstrate the prognostic value of ALDH2 in CRC as it regulates both CRC stemness and migration. Our findings also propose that the plant‐derived isoflavone daidzein could be a potential chemotherapeutic drug targeting ALDH2 in CRC.
One “C” to Rule Them All: The Psychology of Creativity Needs to Refocus on Behaviors
Authors: Bonetto Eric , Arciszewski Thomas 
Published: May 2023

ABSTRACTThe 7C's of creativity (Lubart, 2017) summarize scientific contributions in seven categories as a function of their main object of interest in relation to creativity: Creators, Creating, Collaboration, Context, Creations, Consumption, and Curricula. In its attempt to grasp these different dimensions of the phenomenon of creativity, the psychology of creativity seems to have lost sight of its main object of interest: creative human behavior. This contribution constitutes a short plea to restore “Creating” (i.e., the creative behavior), to its central place in the psychology of creativity. Indeed, the study of the C's of creativity only makes sense in the articulation with the “why” and the “how” of creative behavior. This means focusing on behavioral measures, or at least explicitly considering a direct link between the variables under study and actual creative behaviors. Not all C's are equal, and “Creating” should be the main phenomenon of interest for the discipline. This proposition echoes the various calls to refocus on the study of behavior and behavioral measures in psychology. Research in the field of the psychology of creativity, and especially in the Journal of Creative Behavior, cannot ignore the need to focus on creative behavior.
YAP/TEAD1 and β‐catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells
Authors: Wang Peiqi , Huang Lingyi , Yang Fan , Chen Wanxi , Bai Ding , Guo Yongwen 
Published: May 2023

AbstractBone remodeling is vital to the maintenance of bone homeostasis and may lead to destructive skeletal diseases once the balance is disrupted. Crosstalk between Wnt and estrogen receptor (ER) signaling has been proposed in bone remodeling, but the underlying mechanism remains unclear. This study was designed to explore the effect of Wnt‐ER signaling during the osteogenic differentiation of bone marrow stromal cells (BMSCs). Rat BMSCs were isolated and identified using flow cytometry and stimulated with Wnt3a. Wnt3a treatment promoted osteogenic differentiation and mineralization of the BMSCs. Meanwhile, Wnt3a enhanced the expression of ERα as well as the canonical Wnt signaling mediator β‐catenin and the alternative Wnt signaling effector Yes‐associated protein 1 (YAP1). Interestingly, DNA pulldown assay revealed direct binding of transcriptional enhanced associate domain 1 (TEAD1) and lymphoid enhancer binding factor 1 (LEF1), transcriptional partners of YAP1 and β‐catenin, respectively, to the promoter region of ERα. In addition, inhibition of TEAD1 and LEF1 suppressed Wnt3‐promoted BMSC osteogenic differentiation and blocked Wnt3a‐induced ERα expression. Furthermore, an in vivo model of femoral bone defect also supported that Wnt3a facilitated bone healing in an ERα‐dependent way. Together, we suggest that Wnt3a promotes the osteogenic activity of BMSCs through YAP1 and β‐catenin‐dependent activation of ERα, via direct binding of TEAD1 and LEF1 to the ERα promoter.