bluuebunny/crossref_metadata_2025_split huggingface dataset:
Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1
Authors: Yoon Ina , Kim Sulhee , Cho Minjae , You Kyung Ah , Son Jonghyeon , Lee Caroline , Suh Ji Hun , Bae Da‐Jeong , Kim Jong Min , Oh Sinae , Park Songhwa , Kim Sanga , Cho Seong Hyeok , Park Seonha , Bang Kyuhyeon , Seo Minjeong , Kim Jong Hyun , Lee Bongyong , Park Joon Seok , Hwang Kwang Yeon , Kim Sunghoon 
Published: May 2023

AbstractProlyl‐tRNA synthetase 1 (PARS1) has attracted much interest in controlling pathologic accumulation of collagen containing high amounts of proline in fibrotic diseases. However, there are concerns about its catalytic inhibition for potential adverse effects on global protein synthesis. We developed a novel compound, DWN12088, whose safety was validated by clinical phase 1 studies, and therapeutic efficacy was shown in idiopathic pulmonary fibrosis model. Structural and kinetic analyses revealed that DWN12088 binds to catalytic site of each protomer of PARS1 dimer in an asymmetric mode with different affinity, resulting in decreased responsiveness at higher doses, thereby expanding safety window. The mutations disrupting PARS1 homodimerization restored the sensitivity to DWN12088, validating negative communication between PARS1 promoters for the DWN12088 binding. Thus, this work suggests that DWN12088, an asymmetric catalytic inhibitor of PARS1 as a novel therapeutic agent against fibrosis with enhanced safety.
Implementing a Post-Discharge Telemedicine Service Pilot to Enhance the Hospital to Home Transition
Authors: Haimowitz Rachel L. , Halley Tina V. , Driskill Christina , Kendall Morgan , Parikh Kavita 
Published: May 2023

OBJECTIVES
The objectives of this study are to (1) describe our postdischarge telemedicine program and (2) evaluate program implementation.

METHODS
At our single-center tertiary care children’s hospital, we launched our postdischarge telemedicine program in April 2020. We used the Template for Intervention Description and Replication framework to describe our pilot program and Proctor’s conceptual framework to evaluate implementation over a 9-month period. Retrospective chart review was conducted. Descriptive analyses were used to compare demographics and health care reutilization rates across patients. Implementation outcomes included adoption (rate of scheduled visits) and feasibility (rate of completed visits). Effectiveness outcomes included the rate of postdischarge issues and unscheduled healthcare utilization.

RESULTS
We established a postdischarge telemedicine program for a general pediatric population that ensured follow-up at a time when in-person evaluation was limited because of the coronavirus disease 2019 pandemic. For implementation evaluation, we included all 107 patients in the pilot program. Adoption was 100% and feasibility was 58%. Eighty-two percent of patients completing a visit reported one or more postdischarge issues. There was no difference in health system reutilization between those who completed a visit and those who did not.

CONCLUSIONS
Implementation of a postdischarge telemedicine service is achievable and promotes early detection of failures in the hospital to home transition. Directions for future study will include rigorous program evaluation via telemedicine program assessment tools and sustainability efforts that build upon known implementation and health service outcomes.
Investigation of the Therapeutic Value of Verbascum pyramidatum Bieb. for Obesity
Authors: SENER Sıla , BADEM Merve , ÇATALBAŞ Mehmet , KANBOLAT Şeyda , ÖZGEN Ufuk , ULAŞ ÇOLAK Nevin 
Published: May 2023

Nowadays, one of the therapeutic approaches for obesity is the use pancreatic lipase inhibitors which reduce the digestion and absorption of fats. Most research indicates that natural sources which have a lipase inhibitory effect, may be utilized to treat obesity. Verbascum pyramidatum is one of the potential natural sources for obesity, and it has been demonstrated to have anti-inflammatory, antidiabetic, and regulatory effects on lipid metabolism. With this study, V. pyramidatum's potential lipase inhibitor effect, it is aimed to reveal its value in the treatment of obesity.
In vitro spectroscopic method was used to determine the lipase inhibitory effect of V. pyramidatum. The quantitative investigation of V. pyramidatum's phenolic metabolites with antiobesity activity was carried out utilizing the Reverse Phase-High Performance Liquid Chromatography method.
In this reported study, it was proven that extract and all fractions had an impact that inhibited lipase, with the ethyl acetate extract showing the highest inhibitory effect. Additionally, it was revealed through HPLC analysis that the species included p-OH benzoic acid, coumaric acid, quercetin, sinapic acid, and syringaldehyde. It has been demonstrated that V. pyramidatum may be a promising candidate for obesity treatment, but further investigations are required to use it as a therapeutic agent.
miR-147 Represses NDUFA4, Inducing Mitochondrial Dysfunction and Tubular Damage in Cold Storage Kidney Transplantation
Authors: Zhu Jiefu , Xiang Xiaohong , Hu Xiaoru , Li Chenglong , Song Zhixia , Dong Zheng 
Published: May 2023

Significance Statement
Cold storage-associated transplantation (CST) injury occurs in renal transplant from deceased donors, the main organ source. The pathogenesis of CST injury remains poorly understood, and effective therapies are not available. This study has demonstrated an important role of microRNAs in CST injury and revealed the changes in microRNA expression profiles. Specifically, microRNA-147 (miR-147) is consistently elevated during CST injury in mice and in dysfunctional renal grafts in humans. Mechanistically, NDUFA4 (a key component of mitochondrial respiration complex) is identified as a direct target of miR-147. By repressing NDUFA4, miR-147 induces mitochondrial damage and renal tubular cell death. Blockade of miR-147 and overexpression of NDUFA4 reduce CST injury and improve graft function, unveiling miR-147 and NDUFA4 as new therapeutic targets in kidney transplantation.

Background
Kidney injury due to cold storage–associated transplantation (CST) is a major factor determining the outcome of renal transplant, for which the role and regulation of microRNAs remain largely unclear.

Methods
The kidneys of proximal tubule Dicer (an enzyme for microRNA biogenesis) knockout mice and their wild-type littermates were subjected to CST to determine the function of microRNAs. Small RNA sequencing then profiled microRNA expression in mouse kidneys after CST. Anti–microRNA-147 (miR-147) and miR-147 mimic were used to examine the role of miR-147 in CST injury in mouse and renal tubular cell models.

Results
Knockout of Dicer from proximal tubules attenuated CST kidney injury in mice. RNA sequencing identified multiple microRNAs with differential expression in CST kidneys, among which miR-147 was induced consistently in mouse kidney transplants and in dysfunctional human kidney grafts. Anti–miR-147 protected against CST injury in mice and ameliorated mitochondrial dysfunction after ATP depletion injury in renal tubular cells in intro. Mechanistically, miR-147 was shown to target NDUFA4, a key component of the mitochondrial respiration complex. Silencing NDUFA4 aggravated renal tubular cell death, whereas overexpression of NDUFA4 prevented miR-147–induced cell death and mitochondrial dysfunction. Moreover, overexpression of NDUFA4 alleviated CST injury in mice.

Conclusions
microRNAs, as a class of molecules, are pathogenic in CST injury and graft dysfunction. Specifically, miR-147 induced during CST represses NDUFA4, leading to mitochondrial damage and renal tubular cell death. These results unveil miR-147 and NDUFA4 as new therapeutic targets in kidney transplantation.
First experience of trachea stenting using a Y-shaped stent. Clinical observation
Authors: Iurichev I. N. , Vereshchak V. V. , Gruzdev V. E. , Anisimov M. A. , Filatov A. A. 
Published: May 2023

Endoscopic trachea stenting is a pressing issue in modern endoscopy. This method is applied in various diseases including benign stenoses associated with complications after long-term mechanical ventilation, malignant stenoses (oncological diseases of the trachea itself, compression from outside by esophageal or mediastinal tumors), post-injury stenoses and developmental defects.Currently, a certain contingent of patients exists for whom trachea prosthesis and its bifurcation remain the only possible option for stepwise or final treatment. If the lower third of the trachea, bifurcation zone or the main bronchi are affected, the optimal technique is stenting with Y-shaped stents which provide maximal patency of the airways.
Proyectos de inmigración africana en el Perú (1860-1871)
Authors: Tardieu Jean-Pierre 
Published: May 2023

A mediados del siglo XIX, la mano de obra esclava se vio reemplazada rápidamente por la china, y fue apartir de ese momento -a raíz de los problemas que tuvieron los culíes para adaptarse al trabajo en la agricultura costera- que surgió una visión paternalista con respecto al negro, visión que lo consideraba más dócil y trabajador que el chino.Por ello, se volvió a plantear la posibilidad de iniciar una inmigración africana hacia el Perú, que buscaría que el negro llegara como trabajador contratado al país. Así, el presente artículo analiza los distintos proyectos de inmigración negra planteados por José Gregario García(1860), Juan Larregle y Aureliano Olano (1869-1870) y Juan Manuel Noriega (1871), y la reacción de la opinión pública, que veía en estos proyectos reminiscencias de la trata esclavista.
Alcances y límites de un proyecto ilustrado: la Sociedad de Amantes del País y el Mercurio Peruano
Authors: Guibovich Pérez Pedro 
Published: May 2023

La Sociedad de Amantes del País y su vocero el Mercurio Peruano fueron dos de las manifestaciones más importantes de la cultura ilustrada en el virreinato peruano a fines del siglo XVIII. Sobre ambos existe una abundante bibliografía que postula que su fracaso fue consecuencia de la censura oficial debido a su discurso crítico. Este artículo cuestiona dicha interpretación a partir del estudio de la relación entre la Sociedad y la politica reformista borbónica y del uso de nueva documentación.
De rústicos a civilizados. El concepto de civilidad en tres historias de la América Meridional del siglo XVIII
Authors: Peralta Ruiz Víctor 
Published: May 2023

A partir de las historias civiles sobre el Perú, Quito y Chile escritas, respectivamente, por el ilustrado limeño José Eusebio Llano Zapata y los jesuitas desterrados en Italia Juan de Velasco y Juan Ignacio Molina, este artículo discute el distinto uso que los autores hicieron del concepto de civilidad, el que esgrimieron además como rechazo a la supuesta inferioridad de sus respectivas patrias. Tal discusión está precedida por una reflexión sobre las particulares condiciones de producción de estos tres textos históricos, en que se señalan los motivos del éxito o fracaso de sus ediciones. Este estudio llama la atención sobre la importancia de la escritura de la historia de la América Meridional como un proyecto científico-cultural de carácter no solo oficial, sino también particular.---This article examines the civil histories of Peru, Quito, and Chile authored by the erudite limeño José Eusebio Llano Zapata, and the exiled Jesuits Juan de Velasco and Juan Ignacio Molina, respectively. It examines the authors’ interpretations of the concept of civility as a means of rejecting the alleged inferiority of their homelands. Consideration is given to the specific contexts in which the works were produced and the reasons for the success or failure of their publication. The study argues that the writing of the history of South America was a social and cultural project of an official as well as personal nature.
El carro de Ezequiel: la monarquía hispana de fray Buenaventura de Salinas y Córdova
Authors: Gálvez Peña Carlos M. 
Published: May 2023

Una lectura crítica del tercer y casi desconocido memorial del franciscano Buenaventura de Salinas y Córdova (Madrid, 1639) revela interesantes ideas sobre economía y política virreinales, las cuales no están presentes en su obra más conocida: Memorial de las historias del Nuevo Mundo Pirú (Lima, 1630). El texto de 1639 permite establecer conexiones temáticas al interior de su obra y entre esta y la de otros autores contemporáneos. De esta manera se sitúa a Salinas en el contexto ideológico del siglo XVII y se entiende mejor la génesis de sus ideas. Se discute, asimismo, la validez de la categoría cronista, usada antes para este autor, y se propone la de letrado de la temprana modernidad.
El teatro cortesano en la Lima colonial: recepción y prácticas escénicas
Authors: Rodríguez Garrido José A. 
Published: May 2023

Desde 1672 hasta 1747 se documenta en Lima un significativo conjunto de representaciones teatrales «a la italiana» (es decir, montajes que hacen uso de recursos escénicos espectaculares), vinculadas siempre a celebraciones de carácter imperial. A partir de un corpus de quince obras teatrales, se estudian en este trabajo algunas de las condiciones de recepción y los medios materiales que permitieron este particular desarrollo del teatro en la sede del virreinato del Perú: el contexto y los fines de estas representaciones, el lugar donde se levantaba el escenario, el público al que se dirigían y los medios escénicos que se emplearon.
Las guerrillas peruanas de 1965: entre los movimientos campesinos y la teoría foquista
Authors: Rubio Giesecke Daniela 
Published: May 2023

La ideología que guió la acción revolucionaria de las guerrillas en el Perú en 1965 es el tema del presente artículo. Este sostiene que en aquellas zonas donde hubo una fuerte organización campesina, la guerrilla no tuvo éxito porque fue vista como un elemento externo. En el texto se analizan la composición social e ideología de los principales agentes sociales (campesinos y guerrilleros) y la interacción entre ambos. En suma, se trata de una nueva lectura del accionar de los grupos de izquierda radical a mediados de la década de 1960.
Conectando territorios y sociedades. La movilidad de los misioneros jesuitas en el mundo ibérico (siglos XVI-XVIII)
Authors: Maldavsky Aliocha 
Published: May 2023

El objeto de este artículo es estudiar la movilidad de los miembros de la Compañía de Jesús como uno de los ejemplos de la conexión entre los diferentes territorios europeos y americanos de la monarquía española en la Edad Moderna. Se trata también de reflexionar acerca de la relación que puede existir, en un mundo hispanoamericano caracterizado por una situación de dominación colonial y el nacimiento de nuevas sociedades y territorios, entre la movilidad de los religiosos y su arraigo local.
Encadrement juridique de la vente en ligne de vins, bières et spiritueux
Authors: Boudier Thomas , Gignoux Suzanne 
Published: May 2023

La vente en ligne de vins, bières et spiritueux est une opportunité pour les professionnels du secteur.
Il faudra toutefois veiller à respecter les règles applicables à la vente en ligne de manière générale, ainsi que les règles propres à la commercialisation de ces produits.
Le marché de la vente de vins, bières et spiritueux en ligne connaît un essor important tout en demeurant encore modeste par rapport à la commercialisation traditionnelle tant sur le marché intérieur qu’à l’export.
Il est donc assez raisonnable de penser que la première continuera de se développer à un bon rythme, sans néanmoins s’aventurer à affirmer si elle le fera au détriment ou en complément de la seconde.
Time To See if Fracturing for Steam Pays Off
Authors: Rassenfoss Stephen 
Published: May 2023

Two test sites in the southwest US have successfully fractured geothermal injection wells in hot, dry hard-rock formations. Now it is time to find out if they can create really hot water by pumping cold water through the fractures in that hot rock into a second well.
Both Fervo Energy and Utah FORGE test sites are using fracturing and reported hopeful signs at the recent SPE Hydraulic Fracturing Technology Conference and Exhibition (HFTC).
But there are some fundamental differences in the goals of the organizations behind those test sites.
Fervo is a startup with an aggressive timeline for commercial geothermal development that uses widely applied methods developed to produce oil and gas from extremely tight rock.
FORGE is a research site managed by the University of Utah and funded by the US Department of Energy (DOE). Its goals are to help launch geothermal in hot, dry rocks by trying a number of approaches, as well as promoting the development and testing of tools needed in extremely hot formations.
So far, both sites have shown it is possible to fracture the hard rock in granitic or metamorphosed formations. It appears they both created the long, simple fractures needed for high-volume flows.
During a panel discussion at the opening session of HFTC, Jack Norbeck, Fervo’s co-founder, and chief technology officer, played up the connections between fracturing for oil production and geothermal.
“There’s a lot of similarities about what we’re trying to do and what y’all do every day. Probably the biggest difference is that we try to actually achieve frac hits,” he said.
Fervo’s testing is further along, with the second well of its pair of horizontal wells drilled, which FORGE will be doing later this spring. While drilling, they collected proppant from the first well, which will be the injector, indicating a fracture connecting the pair.
Fervo’s modeling suggests they created a fracture network with the surface area needed to heat the 40,000–60,000 B/D of steam needed per well, which is in line with FORGE’s well capacity, Norbeck said. High-volume flows matter because the high upfront cost of building a hot-rock injection geothermal system limits the number of wells they can build per power plant.
“We were able to show that the stimulator reservoir volumes that we generated in this project were sufficient for economic production,” Norbeck said.
As with fracturing for oil production, creating a large volume of fractured surface area is a prerequisite. But they still need to show they can produce enough water at a high enough temperature over a long period of time.
A Trigonometric Spline Method for a Singularly Perturbed Parabolic Time-Dependent Partial Differential - Difference Equations Arising in Computational Neuroscience
Authors: Lalu M , G B.S.L. Soujanya , Phaneendra K. 
Published: May 2023

Abstract

We examine a computational technique for a singularly perturbed parabolic partial differential equation with mixed small shifts arguments, whose solution displays parabolic boundary layer behaviour. To derive the scheme, backward Euler approach was used for temporal discretization, and a trigonometric spline method was used for spatial discretization. The Taylor series is utilized to estimate the shift terms, resulting in a singularly perturbed parabolic differential equation with a nearby singularly perturbed parabolic differential equation. The existence and uniqueness of a solution for the proposed technique are investigated. The scheme is proven to be fourth order convergent in space and first order convergent in time. The accuracy of the suggested spline numerical approach is demonstrated by comparing numerical results with those obtained using other approaches.
2010mathematics Subject Classification. 65L10, 65L11, 65L12
Application of Time Series Analysis to Vendor Selection Problem:
A Problem of Multi-Objective Decision Making
Authors: Gupta Srikant , Gupta Neha , Kamal Murshid 
Published: May 2023

Abstract
The attainment of a competitive advantage can be facilitated by the presence of a vendor who is both effective and efficient. The process of selecting a vendor is a complex decision-making task that entails consideration of multiple quantitative and qualitative factors. The objective of this study is to minimise the net ordering cost, transportation cost, and late deliveries. When examining the various circumstances of existence, it is impossible to make anticipatory prognostications. The utilisation of Interval type-2 trapezoidal fuzzy numbers has been employed to effectively demonstrate the presence of uncertainty in the input parameters. A precise equivalent form has been derived through the calculation of the expected value. Exponential smoothing forecasting analysis has been utilised to ascertain the precise demand for the product in order to mitigate the risk of shortages and consequent financial losses. Ultimately, an effective methodology utilising fuzzy goal programming has been employed to attain a mutually satisfactory solution. The proposed methodology has been elucidated through the addition of a numerical illustration of its underlying concepts.
Fine-Grained Activity Classification in Assembly Based on Multi-Visual Modalities
Authors: Chen Haodong , Zendehdel Niloofar , Leu Ming C. , Yin Zhaozheng 
Published: May 2023

Abstract

Assembly activity recognition and prediction help to improve productivity, quality control, and safety measures in smart factories. This study aims to sense, recognize, and predict a worker's continuous fine-grained assembly activities in a manufacturing platform. We propose a two-stage network for workers' fine-grained activity classification by leveraging scene-level and temporal-level activity features. The first stage is a feature awareness block that extracts scene-level features from multi-visual modalities, including red-green-blue (RGB) and hand skeleton frames. We use the transfer learning method in the first stage and compare three different pre-trained feature extraction models. Then, we transmit the feature information from the first stage to the second stage to learn the temporal-level features of activities. The second stage consists of the Recurrent Neural Network (RNN) layers and a final classifier. We compare the performance of two different RNNs in the second stage, including the Long Short-Term Memory (LSTM) and the Gated Recurrent Unit (GRU). The partial video observation method is used in the prediction of fine-grained activities. In the experiments using the trimmed activity videos, our model achieves an accuracy of > 99% on our dataset and > 98% on the public dataset UCF 101, outperforming the state-of-the-art models. The prediction model achieves an accuracy of > 97% in predicting activity labels using 50% of the onset activity video information. In the experiments using an untrimmed video with continuous assembly activities, we combine our recognition and prediction models and achieve an accuracy of > 91% in real time, surpassing the state-of-the-art models for the recognition of continuous assembly activities.