bluuebunny/crossref_metadata_2025_split huggingface dataset:
The deglaciation of Upernavik trough, West Greenland, and its Holocene sediment infill: processes and provenance
Authors: Weiser Jens , Titschack Jürgen , Hebbeln Dierk 
Published: June 2023

Under glacial climates, continental ice sheets such as, e.g., the Greenland Ice Sheet, extended onto the continental shelves and often carved out deep cross‐shelf troughs. The sedimentary infill of such troughs commonly is a product of the complex interactions between the ice sheets, largely driving sediment input into the ocean, and the surrounding water masses. Off West Greenland, research has focused on the Disko and Uummannaq troughs, leaving the northerly adjacent Upernavik trough relatively understudied. Hence, neither the chronology of deglaciation nor the details of its postglacial infill are sufficiently well understood. Here, we combine computed tomography image‐derived information with geochemical and granulometric data from four sediment cores recovered from the Upernavik trough that point to (i) deglaciation of the mid‐shelf probably around 13.4 cal. ka BP that was most likely driven by a northward advection of warmer Atlantic waters during the Bølling–Allerød, (ii) the presence of widespread mass wasting around 8 cal. ka BP on the inner shelf and (iii) the complex interplay between various modes of sediment input, transport and deposition under hemipelagic sedimentation afterwards. While this interplay complicates provenance studies, we identify two major sediment delivery mechanisms that control transport and deposition from four sediment source areas. Through the Early Holocene the relative contributions of sediments from the various sources changed from a predominantly local origin to more southerly sources, mainly driven by decreasing input from the local sources. The integration of relative sediment source contributions with varying sedimentation rates challenges previous studies postulating intensified sediment delivery from the south through a greater influence of the West Greenland Current and highlights the need for the integration of sediment input and transport mechanisms into provenance studies in the area.
MIR204 n.37C>T variant as a cause of chorioretinal dystrophy variably associated with iris coloboma, early‐onset cataracts and congenital glaucoma
Authors: Jedlickova Jana , Vajter Marie , Barta Tomas , Black Graeme C. M. , Perveen Rahat , Mares Jan , Fichtl Marek , Kousal Bohdan , Dudakova Lubica , Liskova Petra 
Published: June 2023

AbstractFour members of a three‐generation Czech family with early‐onset chorioretinal dystrophy were shown to be heterozygous carriers of the n.37C>T in MIR204. The identification of this previously reported pathogenic variant confirms the existence of a distinct clinical entity caused by a sequence change in MIR204. Chorioretinal dystrophy was variably associated with iris coloboma, congenital glaucoma, and premature cataracts extending the phenotypic range of the condition. In silico analysis of the n.37C>T variant revealed 713 novel targets. Additionally, four family members were shown to be affected by albinism resulting from biallelic pathogenic OCA2 variants. Haplotype analysis excluded relatedness with the original family reported to harbour the n.37C>T variant in MIR204. Identification of a second independent family confirms the existence of a distinct MIR204‐associated clinical entity and suggests that the phenotype may also involve congenital glaucoma.
Decreased YB‐1 expression denervates brown adipose tissue and contributes to age‐related metabolic dysfunction
Authors: Zhou Ruoyu , Huang Yan , Feng Xu , Zhou Rui , Wang Liwen , Xie Genqing , Xiao Yuan , Zhou Haiyan 
Published: June 2023

AbstractThermogenesis in brown adipose tissue (BAT) declines with aging, however, the underlying mechanism remains unclear. Here, we show that the expression of Y‐box binding protein 1 (YB‐1), a critical DNA/RNA binding protein, decreased in the BAT of aged mice due to the reduction of microbial metabolite butyrate. Genetic ablation of YB‐1 in the BAT accelerated diet‐induced obesity and BAT thermogenic dysfunction. In contrast, overexpression of YB‐1 in the BAT of aged mice was sufficient to promote BAT thermogenesis, thus alleviating diet‐induced obesity and insulin resistance. Interestingly, YB‐1 had no direct effect on adipose UCP1 expression. Instead, YB‐1 promoted axon guidance of BAT via regulating the expression of Slit2, thus potentiating sympathetic innervation and thermogenesis. Moreover, we have identified that a natural compound Sciadopitysin, which promotes YB‐1 protein stability and nuclear translocation, alleviated BAT aging and metabolic disorders. Together, we reveal a novel fat‐sympathetic nerve unit in regulating BAT senescence and provide a promising strategy against age‐related metabolic disorders.
Infant‐directed speech facilitates word learning through attentional mechanisms: An fNIRS study of toddlers
Authors: Zhou Xin , Wang Luchang , Hong Xuancu , Wong Patrick C. M. 
Published: June 2023

AbstractThe speech register that adults especially caregivers use when interacting with infants and toddlers, that is, infant‐directed speech (IDS) or baby talk, has been reported to facilitate language development throughout the early years. However, the neural mechanisms as well as why IDS results in such a developmental faciliatory effect remain to be investigated. The current study uses functional near‐infrared spectroscopy (fNIRS) to evaluate two alternative hypotheses of such a facilitative effect, that IDS serves to enhance linguistic contrastiveness or to attract the child's attention. Behavioral and fNIRS data were acquired from twenty‐seven Cantonese‐learning toddlers 15–20 months of age when their parents spoke to them in either an IDS or adult‐directed speech (ADS) register in a naturalistic task in which the child learned four disyllabic pseudowords. fNIRS results showed significantly greater neural responses to IDS than ADS register in the left dorsolateral prefrontal cortex (L‐dlPFC), but opposite response patterns in the bilateral inferior frontal gyrus (IFG). The differences in fNIRS responses to IDS and to ADS in the L‐dlPFC and the left parietal cortex (L‐PC) showed significantly positive correlations with the differences in the behavioral word‐learning performance of toddlers. The same fNIRS measures in the L‐dlPFC and right PC (R‐PC) of toddlers were significantly correlated with pitch range differences of parents between the two speech conditions. Together, our results suggest that the dynamic prosody in IDS increased toddlers’ attention through greater involvement of the left frontoparietal network that facilitated word learning, compared to ADS.Research Highlights
This study for the first time examined the neural mechanisms of how infant‐directed speech (IDS) facilitates word learning in toddlers.
Using fNIRS, we identified the cortical regions that were directly involved in IDS processing.
Our results suggest that IDS facilitates word learning by engaging a right‐lateralized prosody processing and top‐down attentional mechanisms in the left frontoparietal networks.
The language network including the inferior frontal gyrus and temporal cortex was not directly involved in IDS processing to support word learning.
One‐stop procedure of “Atrial fibrillation radiofrequency ablation + left atrial appendage closure” guided by 3D printing technology: A case report
Authors: Liao Nuohan , Qin Zuoan , Luo LI , Ge Liangqing 
Published: June 2023

AbstractLeft atrial appendage occlusion (LAAO) in the treatment of atrial fibrillation (AF) has become a hot topic in clinical research in recent years. We report a 68‐year‐old female with a 3‐year history of paroxysmal atrial fibrillation refractory to antiarrhythmic therapy and unable to tolerate anticoagulation therapy who underwent successful atrial fibrillation radiofrequency ablation combined with left atrial appendage occlusion guided by 3D printing technology. There was no recurrence of her atrial fibrillation and there was continued complete occlusion of her left atrial appendage at 3‐month and 1‐year follow‐ups.This case supports the potential advantage of 3D printing technology to guide a “one‐stop combined AF radiofrequency ablation and left atrial appendage occlusion procedure.” But whether it can improve the prognosis and quality of life of patients, further multi‐center research and large data statistics are required.
Preparing for parenthood: Validating a mixed method approach to assessing the coparenting capacity of young expectant fathers and mothers
Authors: Florsheim Paul , Burrow‐Sánchez Jason J. 
Published: June 2023

AbstractThe transition to parenthood (TP) interview and coparenting capacity (CC) coding scheme is a mixed method approach to evaluating readiness for the interpersonal challenges of parenthood. This paper focuses on the validation of the TP–CC system with a diverse sample of 140 young expectant father/mother pairs. The TP interview is designed to assist expectant parents in expressing their thoughts and feelings about parenthood and coparenting and the CC coding scheme is designed to assess a new parent's capacity for expressing fondness, acceptance, growth, cohesion, and commitment in their relationship with their coparenting partner. Convergent validation of the TP–CC system involved measuring self‐ and partner‐reported relationship quality, relationship security, and observed warmth and hostility during the pregnancy. Predictive validation focused on the same set of variables, measured at the 6‐month postbirth follow‐up. Results supported the convergent validity of the TP–CC system for mothers and fathers, with higher‐specific CC scores correlating with higher relationship quality, relationship security and warmth scores, as well as lower hostility scores. Results partially supported predictive validity, with fathers' total CC scores predicting fathers' interpersonal hostility and mothers' relationship quality, relationship security, hostility, and warmth at follow‐up. Consistently positive and significant correlations between both mothers and fathers prebirth and postbirth CC scores provide evidence for the test–retest reliability of the TP–CC system. Generally, findings demonstrate the potential utility of the TP–CC system for evaluating coparenting readiness across the transition to parenthood.
Association between single‐nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment
Authors: Meyfarth Sandra Regina Santos , Tavares Jhenyfer da Silva , Guimarães Ludmila da Silva , Silva Erlange Andrade Borges , Gaio Daniella Cristina , Ecker Mainara Bassetto , Brancher João Armando , Küchler Erika Calvano , Silva‐Sousa Alice Corrêa , de Sousa‐Neto Manoel Damião , Antunes Lívia Azeredo Alves , Antunes Leonardo Santos 
Published: June 2023

AbstractAimThis study aimed to investigate whether single‐nucleotide polymorphisms (SNPs) in the genes encoding 5‐HTR2A (5‐Hydroxytryptamine (serotonin) receptor 2A) and MTNR1A (melatonin receptor 1A) may contribute to postoperative pain perception after root canal treatment. We hypothesised that SNPs in HTR2A and MTNR1A genes were associated with postoperative pain after root canal treatment.MethodologyThis genetic cohort study enrolled patients with single‐rooted teeth diagnosed with pulp necrosis and asymptomatic apical periodontitis before root canal treatment. Root canal treatment was performed in one session using a standardized protocol. Postoperative pain and tenderness were assessed using a visual analogue scale (recorded every day for 7 days and on the 14th and 30th days after root canal treatment). Genomic DNA was extracted from saliva and used to genotype the SNPs in HTR2A (rs4941573 and rs6313) and MTNR1A (rs6553010, rs6847693 and rs13140012) using real‐time polymerase chain reaction. Genotypes were compared using univariate and multivariate Poisson regression with generalized estimating equations (p < .05).ResultsIn total, 108 patients were enrolled in this study. The SNPs rs6553010 (MTNR1A), rs4941573 and rs6313 (HTR2A) were associated with an increased risk of developing pain after root canal treatment (p < .05).ConclusionsThis study suggests that SNPs in HTR2A and MTNR1A influence pain response after root canal treatment.
Qui veut (dé)réglementer le travail dans les pays en développement? La théorie desinsiders‐outsidersen question
Authors: RONCONI Lucas , KANBUR Ravi , LÓPEZ‐CARIBONI Santiago 
Published: June 2023

RésuméSelon l'approche «insiders‐outsiders», qui domine le discours sur le droit du travail, la législation protectrice de l'emploi favorise les travailleurs dotés d'un emploi stable, les insiders, au détriment des outsiders, moins bien lotis. Les outsiders devraient de ce fait être favorables à la déréglementation. Les auteurs observent pourtant que, dans les pays en développement, ceux‐ci sont au contraire très majoritairement attachés à la protection de l'emploi. Ils plaident donc pour une remise en question de l'opposition traditionnelle entre insiders et outsiders et pour une meilleure prise en compte d'aspects comme la mutualisation des gains, les transitions professionnelles, l'équité ou le pouvoir de l'employeur.
Isotretinoin and timing of procedural interventions: Clinical implications and practical points
Authors: Hatami Parvaneh , Balighi Kamran , Asl Hamed Nicknam , Goodarzi Azadeh , Aryanian Zeinab 
Published: June 2023

AbstractBackgroundFor decades, the notion that elective surgeries and cutaneous procedures should be postponed for 6–12 months in patients on, or recently administered with isotretinoin, has been widely accepted. However, some recent studies showed the need for a change in this regard.MethodHere, we reviewed the existing data in this regard through searching on PubMed, Google Scholar, and Scopus. All of the relevant papers published in English, until October, 2022, which we could access to their full‐texts, were included.ResultsWe found some recommendations made by plastic surgeons, dermatologists, ENT surgeons, ophthalmologists, orthopedic surgeons, and dentists regarding the correct timing of procedural interventions in patients on, or recently administered with isotretinoin and tried to summarize them to provide a practical guide for clinicians.ConclusionPhysicians may discuss with patients regarding the known risk of abnormal wound healing in the setting of systemic isotretinoin treatment and suggest that, when possible, surgical procedures be postponed until the activity of the retinoids has time to subside. It is even more important regarding patients with darker skin phototypes to follow an even more strict guideline.
Consumer financial vulnerability: Review, synthesis, and future research agenda
Authors: Fernández‐López Sara , Álvarez‐Espiño Marcos , Rey‐Ares Lucía , Castro‐González Sandra 
Published: June 2023

AbstractResearch on consumer financial vulnerability (CFV) was especially encouraged in the aftermath of the 2007–2008 financial crisis, becoming a phenomenon of global interest to academics and policy makers. This paper reviews the existing academic literature on CFV with the aim of mapping out four research fields (i.e., the concept, the measures, the methods, and the drivers of this phenomenon) and providing a roadmap for a future research agenda for this field. To this end, we review the last two decades of academic research on households’ financial vulnerability, thereby presenting a hybrid literature review. Evidence from a comprehensive analysis of 98 academic papers suggests that this is still an emerging and highly fragmented field and, therefore, a comprehensive future research agenda is offered, including concrete suggestions for research designs and measurements. The proposal of a homogeneous definition of financial vulnerability, the consideration of measures that include subjective aspects of the phenomenon, the use of qualitative methods, and the development of more detailed theoretical and empirical research on the drivers of CFV, are among the authors’ recommendations for future research.
Accuracy and clinical validity of automated cephalometric analysis using convolutional neural networks
Authors: Kang Seyun , Kim Inhwan , Kim Yoon‐Ji , Kim Namkug , Baek Seung‐Hak , Sung Sang‐Jin 
Published: June 2023

AbstractBackgroundThis study aimed to assess the error range of cephalometric measurements based on the landmarks detected using cascaded CNNs and determine how horizontal and vertical positional errors of individual landmarks affect lateral cephalometric measurements.MethodsIn total, 120 lateral cephalograms were obtained consecutively from patients (mean age, 32.5 ± 11.6) who visited the Asan Medical Center, Seoul, Korea, for orthodontic treatment between 2019 and 2021. An automated lateral cephalometric analysis model previously developed from a nationwide multi‐centre database was used to digitize the lateral cephalograms. The horizontal and vertical landmark position error attributable to the AI model was defined as the distance between the landmark identified by the human and that identified by the AI model on the x‐ and y‐axes. The differences between the cephalometric measurements based on the landmarks identified by the AI model vs those identified by the human examiner were assessed. The association between the lateral cephalometric measurements and the positioning errors in the landmarks comprising the cephalometric measurement was assessed.ResultsThe mean difference in the angular and linear measurements based on AI vs human landmark localization was .99 ± 1.05°, and .80 ± .82 mm, respectively. Significant differences between the measurements derived from AI‐based and human localization were observed for all cephalometric variables except SNA, pog‐Nperp, facial angle, SN‐GoGn, FMA, Bjork sum, U1‐SN, U1‐FH, IMPA, L1‐NB (angular) and interincisal angle.ConclusionsThe errors in landmark positions, especially those that define reference planes, may significantly affect cephalometric measurements. The possibility of errors generated by automated lateral cephalometric analysis systems should be considered when using such systems for orthodontic diagnoses.
Impact of zone geometry on the introduction of myopic defocus in young adult eyes wearing multi‐zone lenses
Authors: Sah Raman Prasad , Meyer Dawn , Jaskulski Matt , Rickert Martin , Cheng Xu , Brennan Noel , Kollbaum Pete S. 
Published: June 2023

AbstractPurposeMultizone contact lenses control myopia progression by proposed introduction of myopic defocus. This project investigated how much of the pupil area and how many dioptres of myopic defocus are introduced by different lens zone geometries with near‐ and off‐axis viewing.MethodsTen young myopic adults (18–25 years) binocularly wore four soft contact lenses including a single vision (SV), concentric‐ring dual‐focus (DF), centre‐distance multifocal (MF) and a RingBoost™ (RB) multi‐zone design containing a combination of coaxial and non‐coaxial zones. A modified aberrometer captured aberrations and pupil sizes at four target vergences between −0.25 and −4.00 D (on‐axis) and across the central ±30° of the horizontal retina (off‐axis). Defocus was quantified as the difference between the measured refractive state and the target vergence within each zone of a multi‐zone design within the pupil and compared with that of equivalent zone areas of the SV lens. The percentage of the pupil containing myopic defocused light for each lens was calculated.ResultsDefocus within the distance correction zones of multi‐zone lenses was similar to that of the SV lens. When viewing on‐axis at −0.25 D target vergence, on average 11% of the pupil was myopic with SV, whereas 62%, 84% and 50% of the pupil was myopic for the DF, MF and RB designs, respectively. At −4.00 D target vergence, all lenses exhibited a systematic decrease in the percentage of pupil area having myopic defocus (SV: 3%; DF: 18%; MF: 5% and RB: 26%). The off‐axis proportions were similar across multi‐zone lenses; however, multi‐zone lenses retained approximately 1.25–3.0× more myopic defocus than the SV lens.ConclusionsSubjects accommodated using the distance‐correction zones of multi‐zone lenses. Multi‐zone contact lenses introduced significant myopic defocus on‐axis and across the central ±30° retina. However, the magnitude and proportion of defocus were influenced by zone geometry, add power and pupil size.
ZmEREB57 regulates OPDA synthesis and enhances salt stress tolerance through two distinct signalling pathways in Zea mays
Authors: Zhu Jiantang , Wei Xuening , Yin Chaoshu , Zhou Hui , Yan Jiahui , He Wenxing , Yan Jianbing , Li Hui 
Published: June 2023

AbstractIn plant, APETALA2/ethylene‐responsive factor (AP2/ERF)‐domain transcription factors are important in regulating abiotic stress tolerance. In this study, ZmEREB57 encoding a AP2/ERF transcription factor was identified and its function was investigated in maize. ZmEREB57 is a nuclear protein with transactivation activity induced by several abiotic stress types. Furthermore, two CRISPR/Cas9 knockout lines of ZmEREB57 showed enhanced sensitivity to saline conditions, whereas the overexpression of ZmEREB57 increased salt tolerance in maize and Arabidopsis. DNA affinity purification sequencing (DAP‐Seq) analysis revealed that ZmEREB57 notably regulates target genes by binding to promoters containing an O‐box‐like motif (CCGGCC). ZmEREB57 directly binds to the promoter of ZmAOC2 involved in the synthesis of 12‐oxo‐phytodienoic acid (OPDA) and jasmonic acid (JA). Transcriptome analysis revealed that several genes involved in regulating stress and redox homeostasis showed differential expression patterns in OPDA‐ and JA‐treated maize seedlings exposed to salt stress compared to those treated with salt stress alone. Analysis of mutants deficient in the biosynthesis of OPDA and JA revealed that OPDA functions as a signalling molecule in the salt response. Our results indicate that ZmEREB57 involves in salt tolerance by regulating OPDA and JA signalling and confirm early observations that OPDA signalling functions independently of JA signalling.
Autoregressive conditional durations: An application to the Surinamese dollar versus the US dollar exchange rate
Authors: Ooft Gavin , Franses Philip Hans , Bhaghoe Sailesh 
Published: June 2023

AbstractThe parallel market nominal exchange rate of the United States dollar vis‐à‐vis the Surinamese dollar (USD/SRD) exhibited periods of severe volatility which were often followed by episodes of stability, usually at a cost of sharp depreciations. This study seeks to model this exchange rate using autoregressive conditional duration models. These models are suitable for modelling events occurring with irregular intervals. Exchange rates in developing countries have distinct features compared to exchange rates in countries with well‐established and accessible financial markets. A key feature is that for these developing countries, exchange rates only occasionally experience jumps. Our findings suggest that past exchange rate changes appear to be a significant driver of future exchange rate jumps. Furthermore, our results show that money, international reserves, and commodity prices can explain jumps in the market USD/SRD exchange rate.