bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cooperative and structural relationships of the trimeric Spike with infectivity and antibody escape of the strains Delta (B.1.617.2) and Omicron (BA.2, BA.5, and BQ.1)
Authors: Souza Anacleto Silva de , Souza Robson Francisco de , Guzzo Cristiane Rodrigues 
Published: March 2023

AbstractHerein, we simulated the trimeric Spike of the variants B.1.617.2, BA.2, BA.5 and BQ.1 for 300 ns. We derived mechanisms by which the substitutions K417N, L452R, N444T and N460K may favor resistance to neutralizing antibodies. The K417N and L452R contribute to the expansion of the networks of hydrogen bonding interactions with neighboring residues, decreasing their capacity to interact with neutralizing antibodies. The SpikeBQ.1possesses two unique K444T and N460K mutations that expand the network of hydrogen bonding interactions. This lysine also contributes one novel strong saline interaction and both substitutions may favor resistance to neutralizing antibodies. We also investigated how the substitutions D614G, P681R, and P681H impact Spike structural conformations and discuss the impact of these changes to infectivity and lethality. The prevalent D614G substitution plays a key role in the communication between the glycine and the residues of a β-strand located between the NTD and the RBD, impacting the transition between up- and down-RBD states. The P681R mutation, found in the Delta variant, favors intra- and inter-protomer correlations between the subunits S1 and S2. Conversely, in Omicron sub-variants, P681H decreases the intra- and inter-protomer long-range interactions within the trimeric Spike, providing an explanation for the reduced fusogenicity of this variant. Taken together, our results enhance the knowledge on how novel mutations lead to changes in infectivity and reveal mechanisms by which SARS-CoV-2 may evade the immune system.
CRISPRa-induced upregulation of humanLAMA1compensates forLAMA2-deficiency in Merosin-deficient congenital muscular dystrophy
Authors: Arockiaraj Annie I. , Johnson Marie A. , Munir Anushe , Ekambaram Prasanna , Lucas Peter C. , McAllister-Lucas Linda M. , Kemaladewi Dwi U. 
Published: March 2023

AbstractMerosin-deficient congenital muscular dystrophy (MDC1A) is an autosomal recessive disorder caused by mutations in theLAMA2gene, resulting in a defective form of the extracellular matrix protein laminin-α2 (LAMA2). Individuals diagnosed with MDC1A exhibit progressive muscle wasting and declining neuromuscular functions. No treatments for this disorder are currently available. We previously showed that postnatalLama1upregulation, achieved through CRISPR activation (CRISPRa), compensates forLama2deficiency and prevents neuromuscular pathophysiology in a mouse model of MDC1A. In this study, we assessed the feasibility of upregulating humanLAMA1as a potential therapeutic strategy for individuals with MDC1A, regardless of their mutations. We hypothesized that CRISPRa-mediated upregulation of humanLAMA1would compensate for the lack ofLAMA2and rescue cellular abnormalities in MDC1A fibroblasts. Global transcriptomic and pathway enrichment analyses of fibroblasts collected from individuals carrying pathogenicLAMA2mutations, compared with healthy controls, indicated higher expression of transcripts encoding proteins that contribute to wound healing, including Transforming Growth Factor-β (TGF-β) and Fibroblast Growth Factor (FGF). These findings were supported by wound-healing assays indicating that MDC1A fibroblasts migrated significantly more rapidly than the controls. Subsequently, we treated the MDC1A fibroblasts withSadCas9-2XVP64 and sgRNAs targeting theLAMA1promoter. We observed robustLAMA1expression, which was accompanied by significant decreases in cell migration and expression ofFGFR2, TGF-β2, and ACTA2, which are involved in the wound-healing mechanism in MDC1A fibroblasts.Collectively, our data suggest that CRISPRa-mediatedLAMA1upregulation may be a feasible mutation-independent therapeutic approach for MDC1A. This strategy might be adapted to address other neuromuscular diseases and inherited conditions in which strong compensatory mechanisms have been identified.
In-plane compression performance of additively manufactured honeycomb structures: a review of influencing factors and optimisation techniques
Authors: Obadimu Solomon O. , Kourousis Kyriakos I. 
Published: March 2023

PurposeHoneycombs enjoy wide use in various engineering applications. The emergence of additive manufacturing (AM) as a method of customisable of parts has enabled the reinvention of the honeycomb structure. However, research on in-plane compressive performance of both classical and new types of honeycombs fabricated via AM is still ongoing. Several important findings have emerged over the past years, with significance for the AM community and a review is considered necessary and timely. This paper aims to review the in-plane compressive performance of AM honeycomb structures.Design/methodology/approachThis paper provides a state-of-the-art review focussing on the in-plane compressive performance of AM honeycomb structures, covering both polymers and metals. Recently published studies, over the past six years, have been reviewed under the specific theme of in-plane compression properties.FindingsThe key factors influencing the AM honeycombs' in-plane compressive performance are identified, namely the geometrical features, such as topology shape, cell wall thickness, cell size and manufacturing parameters. Moreover, the techniques and configurations commonly used for geometry optimisation toward improving mechanical performance are discussed in detail. Current AM limitations applicable to AM honeycomb structures are identified and potential future directions are also discussed in this paper.Originality/valueThis work evaluates critically the primary results and findings from the published research literature associated with the in-plane compressive mechanical performance of AM honeycombs.
Perry Starlight, Ali Orbit and Kim Cosmos' alien encounter: creating a picturebook as information for children and parents participating in research
Authors: Smales Katharine , Lloyd Annemaree , Rayner Samantha 
Published: March 2023

PurposeThis study explored whether the creation of an illustrated picturebook could explain the terms and practicalities of participatory, multi-method qualitative research to children aged four to eight years and their parents/carers, creating conditions to seek agreement to their participation, by using an age-appropriate design whilst adhering to ethical guidelines. The purpose of this paper is to explore how this was done addressing these issues.Design/methodology/approachDrawing on the researcher's previous professional experience working in children's publishing and taking an innovative and collaborative approach to giving information to child and parent/carer co-researchers, the researcher and an illustrator created a picturebook both as an eBook and a paperback book to recruit and explain research and co-researchers’ roles to young children and their parents/carers.FindingsThe picturebook successfully recruited 30 children and their parents/carers. Other children expressed their wish not to participate. These findings suggest that greater consideration should be given to the ways information is given to potential research participants, particularly the visual, material and paratextual elements of the information sheets and consent forms routinely used in research.Originality/valueThis paper offers insight into the publishing practicalities of creating innovative ways of giving information about research participation to children and parents/carers and how these ways might foster rich data collection.
Dividend policy and firm value: evidence of financial firms from Borsa Istanbul under the IFRS adoption
Authors: Abdullah Hariem , Isiksal Aliya Zhakanova , Rasul Razha 
Published: March 2023

Purpose
This paper aims to examine the effect of dividend policy on firm value for financial sector in an emerging country. Furthermore, it examines the moderating effect of IFRS adoption and the abolishment of mandatory dividend payment policy with considering the Lintner model of dividend smoothing.

Design/methodology/approach
Data were collected from 111 firms listed on Borsa Istanbul in the financial sector in Turkey over 1995–2017. Using an explanatory research design, this study performs various multivariate regression techniques to investigate the proposed relationships.

Findings
The outcomes demonstrate a positive and significant association between dividend policy and firm value. In addition, the relationship has strengthened after IFRS adoption, indicating that accounting information such as dividend-based ratios prepared under IFRS is more value relevant. The empirical outcomes supported the Lintner model, which is persistent with the signalling hypothesis. Moreover, the findings state that the abolishment of mandatory dividend payment in 2009 strengthened the association between dividend policy and firm value for financial institutions in Turkey.

Practical implications
These results provide an insight to the investors and managers that the effect of IFRS adoption and other policy changes could be greater on the association between dividend policy and firm value. The study empirically tests Lintner model of dividend smoothing for financial firms in an emerging economy.

Originality/value
This study contributes to the literature through providing vital insights on the relationship between dividend policy and firm value and empirically revisiting the Lintner model for financial sector in a developing economy, specifically Turkey. Furthermore, it addresses the influence of IFRS implementation on the association between dividend policy and firm value. These findings are robust to alternative sampling methods and to controlling for other factors which influence firm value.
Intentions and donations: monetary charity in Kuwait during the COVID-19 pandemic
Authors: Al-Shamali Sarah , Kashif Muhammad 
Published: March 2023

Purpose
This study aims to investigate the intentions of individuals’ monetary charity during the COVID-19 crisis in Kuwait. The new conditions of COVID-19 enhanced both the theoretical as well as empirical importance of understanding how charities canalize monetary donations toward those in need.

Design/methodology/approach
An initial framework is developed based on the theory of planned behavior (TPB) to conceptualize how an individual’s intention of donating money to charitable organizations is realized in their behaviors. A cross-sectional study of 276 donors is conducted.

Findings
Explained variance gained is 0.73% suggesting that during the pandemic, donors are financially able to donate and prioritize easily accessible channels to transfer monetary charity. Donor attitudes towards charitable organizations were found to be insignificant regardless of the mismanagement reported.

Practical implications
This study importantly discusses public behavior toward charities during the pandemic and suggests policies for managing such charities during a pandemic for optimizing their effectiveness.

Originality/value
This paper used a contemporary context to measure behavioral intentions including attitude (attitude toward making a financial donation, attitude toward charitable organizations and the attitude toward helping others), perceived behavioral control, descriptive norms, moral norms, injunctive/prescriptive norms and past behavior and thus enhance the empirical base of the TPB.
Meeting in the middle: experiences of citizenship in community-engaged psychosis research
Authors: Higgs Rory , Liao Anne , Windsor Tracy , Ben-David Shelly 
Published: March 2023

Purpose
Previous research has highlighted the importance of engaging people with lived experience (PWLE) in the knowledge creation process. However, diverse approaches to engagement exist. In addition, tensions remain in community-engaged research (CER), including how to address structural inequalities in research settings. This study aims to consider how CER interacts with citizenship within and beyond the research context.

Design/methodology/approach
This study discusses the authors’ experiences as a majority-PWLE of psychosis research team in Canada, including successes and challenges the authors experienced building their team and navigating research institutions. This study also reflects on the authors’ pathways through citizenship, prior to and during the research process. This study discusses divergent models of CER and their applicability to the cyclical process of citizenship and community participation.

Findings
Relationships between academic and peer researchers developed organically over time. However, this study was limited by structural barriers such as pay inequality and access to funding. The authors recognize that there are barriers to full citizenship and acknowledge their resources and privilege of being well supported within their communities. Team members built on a foundation of citizenship to access participation in research. This led to opportunities to engage in community spaces, and for PWLE to participate in research as partners and leaders. This study also found that citizenship is a way of giving back, by building a sense of social responsibility.

Originality/value
Academic and peer researchers can reflect on the authors’ experiences to build more inclusive research teams and communities by using a citizenship approach to research participation.
Reducing inequalities through strengths-based co-creation: indigenous students’ capabilities and transformative service mediator practices
Authors: Davey Janet , Johns Raechel , Blackwell James 
Published: March 2023

Purpose
Service marketers are increasingly aware of inequalities triggered by service systems and the need to prioritize practical strategies for reducing inequalities. A priority area for the Australian Government is reducing university education inequities for Indigenous Australians. This paper aims to examine how Indigenous Australian university students build and leverage their capabilities and strengths, harnessing service providers’ efforts towards enhancing participation (and completion) in university education – an essential transformative outcome for reducing inequalities.

Design/methodology/approach
A three-stage qualitative research process explored student retention/completion and capability building among a sample of Indigenous Australian university students, typically under-represented in the higher education sector.

Findings
Applying a manual thematic analysis, the findings reveal Indigenous students’ value co-creating capabilities (summarized in three dimensions) harness multi-actor processes extending beyond the service provider. Five dimensions summarize the service provider’s transformative service activities that strengthen capabilities for Indigenous Australian university students. Networks of place (a structured Indigenous Centre); processes (university systems); and people (social support), including peer-to-peer networks, are important service assemblages.

Practical implications
The authors present implications for supporting Indigenous students in persisting with and completing higher education. More broadly, the authors provide recommendations for service marketers to resolve barriers to service equality and enhance strengths-based approaches to value co-creation.

Originality/value
Underpinned by a strengths-based approach, the authors contribute towards an agenda of sustainable transformative services. Although considerable research reviews the experiences of Indigenous students, little research has taken a transformative service research perspective. Addressing this, the authors propose a conceptual framework linking consumers’ agentic capabilities with transformative service mediator practices.
Repurposed collection marketing and visibility: using LibGuide gallery boxes as virtual library bookshelves
Authors: Mashiyane Dina Mokgadi , Makhurupetsi Tebogo Agnes 
Published: March 2023

Purpose
This paper aims to provide a reflection on innovating and repurposing collection development and marketing strategy, particularly for eBooks in libraries.

Design/methodology/approach
This paper provides a general review where previous research papers on the phenomenon of the study have been consulted.

Findings
The findings indicate that there is a lack of awareness of eBooks and marketing, and virtual bookshelves in the form of LibGuide gallery boxes are identified as a solution in promoting these resources.

Originality/value
This is a valuable contribution that sheds insight on the usage of LibGuide gallery boxes as virtual bookshelves in marketing library resources, particularly eBooks.
“My words matter”: perspectives on evaluation from people who access and work in recovery colleges
Authors: Soklaridis Sophie , Shier Rowen , Black Georgia , Bellissimo Gail , Di Giandomenico Anna , Gruszecki Sam , Lin Elizabeth , Rovet Jordana , Harris Holly 
Published: March 2023

Purpose
The purpose of this co-produced research project was to conduct interviews with people working in, volunteering with and accessing Canadian recovery colleges (RCs) to explore their perspectives on what an evaluation strategy for RCs could look like.

Design/methodology/approach
This study used a participatory action research approach and involved semistructured interviews with 29 people involved with RCs across Canada.

Findings
In this paper, the authors share insights from participants about the purposes of RC evaluation; key elements of evaluation; and the most applicable and effective approaches to evaluation. Participants indicated that RC evaluations should use a personalized, humanistic and accessible approach. The findings suggest that evaluations can serve multiple purposes and have the potential to support both organizational and personal-recovery goals if they are developed with meaningful input from people who access and work in RCs.

Practical implications
The findings can be used to guide evaluations in which aspects that are most important to those involved in RCs could inform choices, decisions, priorities, developments and adaptations in RC evaluation processes and, ultimately, in programming.

Originality/value
A recent scoping review revealed that although coproduction is a central feature of the RC model, coproduction principles are rarely acknowledged in descriptions of how RC evaluation strategies are developed. Exploring coproduction processes in all aspects of the RC model, including evaluation, can further the mission of RCs, which is to create spaces where people can come together and engage in mutual capacity-building and collaboration.
Magnitude of undernutrition and its associated factors in children attending Child Welfare Clinics in Techiman Municipal, Ghana
Authors: Garti Humphery , Wemakor Anthony , Badu Alexander , Bukari Mohammed 
Published: March 2023

Purpose
This study aims to estimate the magnitude of undernutrition and its associated factors [especially child health interventions at Child Welfare Clinics (CWCs)] among children in Techiman Municipality, Ghana.

Design/methodology/approach
A facility-based analytical cross-sectional design involving 403 mothers/caregivers with children. Simple random sampling was used to sample study sites and participants. Child health interventions were assessed by adapting items used in the Ghana Demographics and Health Survey. Weight and length of children were measured and used to calculate anthropometric z-scores based on World Health Organization guidelines. Test for associations was performed using bivariate analysis and multivariate logistic regression. Statistical significance was considered at p < 0.05.

Findings
The magnitudes of stunting, wasting and underweight were 20.6% [95% confidence interval (CI): 17–25], 11.4% (95% CI: 9–15), and 9.7% (95% CI: 7–13) respectively. Children aged 12–17 months [odds ratio (OR) = 3.1; CI: 1.3–7.5], male children (OR = 5.2; CI: 2.7–10.0) and children attending CWC 19–22 times (OR = 28.8; CI: 6.6–125) had increased odds of stunting. Additionally, belonging to households with one child under 5 (OR = 2.7; CI: 1.4–5.1) and using borehole/well water (OR = 2.7; CI: 1.4–5.3) were associated with increased odds of stunting. Similarly, being a female (OR = 3.5; CI: 1.6–8.0) and using borehole/well water (OR = 2.1; CI: 1.0–4.2) were associated with increased odds of underweight.

Originality/value
The magnitude of malnutrition, specifically stunting and wasting, exceeds the threshold for public health significance. CWC attendance frequency, age and sex of the child, number of children under five years old in households and water source were significantly associated with undernutrition.
Harnessing of newly tailored poly (acrylonitrile)-starch nanoparticle graft copolymer for copper ion removal via oximation reaction as a calorimetric sensor
Authors: Mostafa Khaled , Ameen Heba , El-Ebeisy Amal , El-Sanabary Azza 
Published: March 2023

Purpose
Herein, this study aims to use our recently tailored and fully characterized poly acrylonitrile (AN)-starch nanoparticle graft copolymer having 60.1 graft yield percentage as a starting substrate for copper ions removal from wastewater effluent after chemical modification with hydroxyl amine via oximation reaction as a calorimetric sensor.

Design/methodology/approach
The calorimetric sensor batch technique was used to determine the resin's adsorption capacity, while atomic adsorption spectrometry was used to determine the residual copper ions concentration in the filtrate before and after adsorption. This was done to convert the copolymer's abundant nitrile groups into amidoxime groups, and the resulting poly (amidoxime) resin was used as a copper ion adsorbent. To validate the existence of amidoxime groups, the resin was qualitatively characterized using a rapid vanadium ion test and instrumentally using Fourier transform infrared spectroscopy spectra and scanning electron microscopy morphological analysis.

Findings
At pH 7, 400 ppm copper ions concentration and 0.25 g adsorbent at room temperature, the overall adsorption potential of poly (amidoxime) resin was found to be 115.2 mg/g. The process's adsorption, kinetics and isothermal analysis were examined using various variables such as pH, contact time, copper ion concentration and adsorbent dose. To pretend the adsorption kinetics, various kinetics models, including pseudo-first-order and pseudo-second-order, were applied to the experimental results. The kinetic analysis indicated that the pseudo-second-order rate equation promoted the development of the chemisorption phase better than the pseudo-first-order rate equation. In the case of isothermal investigations, a study of observed correlation coefficient (R2) values indicated that the Langmuir model outperformed the Freundlich model in terms of matching experimental data.

Originality/value
To the best of the author's information, there is no comprehensive study for copper ions removal from waste water effluent using the recently tailored and fully characterized poly (AN)-starch nanoparticle graft copolymer having 60.1 graft yield percentage as a starting substrate after chemical modification with hydroxyl amine via oximation reaction as a calorimetric sensor.