bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal dose and type of exercise to reduce pain, anxiety and increase quality of life in patients with fibromyalgia. A systematic review with meta-analysis
Authors: Rodríguez-Almagro Daniel , Del Moral-García María , López-Ruiz María del Carmen , Cortés-Pérez Irene , Obrero-Gaitán Esteban , Lomas-Vega Rafael 
Published: April 2023

The aim of our meta-analysis was to compile the available evidence to evaluate the effect of physical exercise-based therapy (PEBT) on pain, impact of the disease, quality of life (QoL) and anxiety in patients with fibromyalgia syndrome (FMS), to determine the effect of different modes of physical exercise-based therapy, and the most effective dose of physical exercise-based therapy for improving each outcome. A systematic review and meta-analysis was carried out. The PubMed (MEDLINE), SCOPUS, Web of Science, CINAHL Complete and Physiotherapy Evidence Database (PEDro) databases were searched up to November 2022. Randomized controlled trials (RCTs) comparing the effects of physical exercise-based therapy and other treatments on pain, the impact of the disease, QoL and/or anxiety in patients with FMS were included. The standardized mean difference (SMD) and a 95% CI were estimated for all the outcome measures using random effect models. Three reviewers independently extracted data and assessed the risk of bias using the PEDro scale. Sixty-eight RCTs involving 5,474 participants were included. Selection, detection and performance biases were the most identified. In comparison to other therapies, at immediate assessment, physical exercise-based therapy was effective at improving pain [SMD-0.62 (95%CI, −0.78 to −0.46)], the impact of the disease [SMD-0.52 (95%CI, −0.67 to −0.36)], the physical [SMD 0.51 (95%CI, 0.33 to 0.69)] and mental dimensions of QoL [SMD 0.48 (95%CI, 0.29 to 0.67)], and the anxiety [SMD-0.36 (95%CI, −0.49 to −0.25)]. The most effective dose of physical exercise-based therapy for reducing pain was 21–40 sessions [SMD-0.83 (95%CI, 1.1–−0.56)], 3 sessions/week [SMD-0.82 (95%CI, −1.2–−0.48)] and 61–90 min per session [SMD-1.08 (95%CI, −1.55–−0.62)]. The effect of PEBT on pain reduction was maintained up to 12 weeks [SMD-0.74 (95%CI, −1.03–−0.45)]. Among patients with FMS, PEBT (including circuit-based exercises or exercise movement techniques) is effective at reducing pain, the impact of the disease and anxiety as well as increasing QoL.Systematic Review Registration: PROSPERO https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42021232013.
Physiological dynamics as indicators of plant response to manganese binary effect
Authors: Zhenggang Xu , Li Fan , Mengxi Zheng , Yunlin Zhao , Huimin Huang , Guiyan Yang 
Published: April 2023

IntroductionHeavy metals negatively affect plant physiology. However, plants can reduce their toxicity through physiological responses. Broussonetia papyrifera is a suitable candidate tree for carrying out the phytoremediation of manganese (Mn)-contaminated soil.MethodsConsidering that Mn stress typically exerts a binary effect on plants, to reveal the dynamic characteristics of the physiological indexes of B. papyrifera to Mn stress, we conducted pot experiments with six different Mn concentrations (0, 0.25, 0.5, 1, 2, and 5 mmol/L) for 60 days. In addition to the chlorophyll content, malondialdehyde (MDA), proline (PRO), soluble sugar, superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), the absorption and transfer characteristics of Mn, and root structure were also measured.ResultsPhytoremedial potential parameters such as the bioconcentration factor (BCF) and translocation factor (TF) displayed an increasing trend with the increase of Mn concentration. At lower Mn concentrations (&lt;0.5 mmol/L), the TF value was &lt;1 but crossed 1 when the Mn concentration exceeded 100 mmol/L. The Mn distribution in various tissues was in the following order: leaf &gt; stem &gt; root. The root structure analysis revealed that low-level concentrations of Mn (1 mmol/L) promoted root development. Mn concentration and stress duration had significant effects on all measured physiological indexes, and except soluble sugar, Mn concentration and stress time displayed a significant interaction on the physiological indexes.DiscussionOur study demonstrates that the physiological indexes of B. papyrifera display dynamic characteristics under Mn stress. Thus, during the monitoring process of Mn stress, it appears to be necessary to appropriately select sampling parts according to Mn concentration.
Sociocultural predictors of obligatory exercise in young men: A Polish-Chinese comparison
Authors: Guo Shuai , Izydorczyk Bernadetta , Lipowska Małgorzata , Lizinczyk Sebastian , Kamionka Agata , Sajewicz-Radtke Urszula , Radtke Bartosz M. , Liu Taofeng , Lipowski Mariusz 
Published: April 2023

BackgroundObligatory exercise has been shown to have negative physical and mental effects on exercisers and is more prevalent among young people. However, there is limited research on obligatory exercise among young men. Social comparison theory offers a novel perspective to explore the relationship between sociocultural factors and obligatory exercise among young men, which offers an opportunity to understand potential factors contributing to obligatory exercise among young men across different cultures.MethodWe recruited a purposive sample of young people aged 18-30 from Poland (n=79) and China (n=194). Participants completed self-report measures including the Sociocultural Attitudes Toward Appearance Questionnaire3, Inventory of Physical Activity Objectives, and Obligatory Exercise Questionnaire. In the data analysis stage, we examined the strength of the relationships between the independent variables and the dependent variable through multiple regression analysis, and tested the role of the mediating variables.ResultsThe main analyses revealed that Internalization-Athlete was a common direct predictor of obligatory exercise for both Polish and Chinese young men; that there were direct sociocultural predictors of obligatory exercise that were only used in relation to Polish or Chinese young men; and that social adaptation goals for motivation for physical activity mediated the development of obligatory exercise for Polish and Chinese young men, and that there were cross-cultural differences.ConclusionAttention should be paid to their attitudes towards the idea of a muscular and athletic body and socially adapted physical activity motivations when understanding young men’s obligatory exercise, while also considering cross-cultural differences.
Longitudinal associations of concurrent falls and fear of falling with functional limitations differ by living alone or not
Authors: Liu Kehan , Peng Wenting , Ge Song , Li Chunxiao , Zheng Yu , Huang Xiaoting , Liu Minhui 
Published: April 2023

BackgroundFalls and fear of falling (FOF) are independent risk factors for functional limitations in older adults. However, the combined effect of falls and FOF on functional limitations and the moderating role of living alone or not is unclear. We aimed to examine (1) the independent and combined effect of falls and FOF on functional limitations in older adults and (2) whether living alone moderates these associations.MethodsWe used data from the National Health and Aging Trends Study (NHATS) and included 5,950 U.S. community-dwelling older adults aged 65 and older from Round 1 (Year 2011) and Round 2 (Year 2012). Falls and FOF were ascertained by asking participants whether they had any falls in the last year and whether they had worried about falling in the previous month at R1. Assessed functional limitations included any difficulties with mobility, self-care, or household activities at R2. Poisson regression models were used to examine the longitudinal associations of falls and FOF with functional limitations and the moderation effects of baseline living alone.ResultsOf the 5,950 participants, 16.3% had falls only; 14.3% had FOF only; 14.3% had both, and 55.1% had neither at baseline. In the adjusted model, those who experienced concurrent falls and FOF in R1 had a higher risk of functional limitations at R2 than those with neither (Mobility: Incidence risk ratio [IRR] = 1.34, 95% CI: 1.24–1.45; Self-care: IRR = 1.18, 95% CI: 1.11–1.26; Household: IRR = 1.20, 95% CI: 1.11–1.30). Moreover, living alone significantly moderated the longitudinal associations of concurrent falls and FOF with mobility activity limitations.ConclusionThe findings suggest that strategies to improve falls and FOF together could potentially help prevent functional limitations. Older adults who live with others and have falls or FOF should receive interventions to promote their mobility activities.
Virtual reality in chemotherapy support for the treatment of physical functions, fear, and quality of life in pediatric cancer patients: A systematic review and meta-analysis
Authors: Czech Oliver , Rutkowski Sebastian , Kowaluk Aleksandra , Kiper Paweł , Malicka Iwona 
Published: April 2023

BackgroundAppropriately selected complementary therapies, such as virtual reality (VR) and active video games (AVG), provide support to young patients during the process of cancer treatment. Therefore, this systematic review with meta-analysis aimed to analyze the effects of VR and AVG on fear, physical functions, and quality of life.MethodsA systematic search was performed independently in Scopus, PubMed, Embase, Web of Science and Cochrane Library electronic databases for relevant randomized controlled and crossover studies. From a total of 5,963 records, 11 met the inclusion criteria. After full-text screening two publications were excluded, yet six studies were included in the quantitative analysis because three studies had a large discrepancy in their measured outcomes. For methodological quality assessments, the RoB2 software program was used, while RevMan 5.4.1 was used for statistical analysis and meta-analysis. Standard Mean Difference (SMD) outcome measures were used for the analysis. Statistical heterogeneity was assessed using the I2 statistic with a cut-off value of 50% considering intervention and outcome measures.ResultsOur systematic review includes six randomized controlled studies and three randomized crossover studies. The participants represented both sexes and were children and adolescents (&lt;18 years old) with a diagnosis of cancer. The analysis of the results allows for a careful conclusion that VR has the potential to become an accessory tool in rehabilitation and oncologic treatment. All of the included studies noted a significant advantage of this intervention.ConclusionVR has the potential to be an effective and important tool in the oncologic treatment of children. VR immerses the patient, and as a result, produces a distraction that effectively reduces pain associated with standard oncologic care procedures in children. However, this systematic review and meta-analysis highlights the need for more research into the use of VR as support for pediatric oncologic care.Systematic review registrationPROSPERO database (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=319000), CRD42022319000.
Assessing vaccine hesitancy using the WHO scale for caregivers of children under 3 years old in China
Authors: Cao Man , Zhao Jinhong , Huang Cunrong , Wang Xianglin , Ye Lihong , Han Xueyan , Yu Wenzhou , Yin Zundong , Zhang Juan , Liu Yuanli 
Published: April 2023

IntroductionVaccine hesitancy may increase infectious disease burden and impede disease control efforts, while few studies have measured such a phenomenon with a standardized tool in China. This study aimed to test the validation of the Vaccine Hesitancy Scale (VHS) developed by the WHO SAGE Working Group among caregivers and examine demographic characteristics associated with caregiver hesitancy in six provinces of China.MethodsUsing a multistage sampling design, this study was conducted in 36 immunization clinics in six provinces from December 2019 to August 2020. Caregivers of children aged 0–3  years were included. The VHS was used to assess vaccine hesitancy. The construct validity and internal consistency of the scale were assessed. Associations between caregivers’ characteristics and vaccine hesitancy were examined by simple and multiple linear regression models.ResultsOf the 3,359 participants included, a two-factor structure within the scale was identified, consisting of “lack of confidence” (1.89 ± 0.53) and “risks” (3.20 ± 0.75). Caregivers engaged in medical work expressed more confidence and were less concerned about risks compared to those of non-medical staff (p &lt; 0.05). Participants with higher income levels were more confident (p &lt; 0.05), while those surveyed after the COVID-19 pandemic, who were mothers, who had an older child, or who were raising a second or above birth child, had less concern about risks (p &lt; 0.05).DiscussionWe found that the VHS had acceptable reliability and construct validity and caregivers’ hesitancy was driven more by concerns about risks than by the lack of confidence. Countering these concerns will be particularly important among non-medical staff, lower income, child’s fathers, having a younger child, or raising first-birth child groups.
Enhancing disaster response of emergency medical teams through “TEAMS 3.0” training package—Does the multidisciplinary intervention make a difference?
Authors: Kaim Arielle , Bodas Moran , Camacho Nieves Amat , Peleg Kobi , Ragazzoni Luca 
Published: April 2023

BackgroundIn the aftermath of disasters, Emergency Medical Teams (EMTs) are dispatched to help local rescue efforts. Although EMTs are recognized to be a critical component of the global health workforce, concerns have emerged over their functioning and effectiveness. For example, lack of cooperation and coordination between different EMTs has been a longstanding issue, resulting in fragmented disaster management.MethodsTo enhance the provision of EMT’s field teamwork, the Training for Emergency Medical Teams and European Medical Corps (TEAMS) project was established, and later further updated with novel scenarios and exercises (i.e., adapting EMT operations to a sudden disaster; becoming a modular team; reflecting on ethical dilemmas) in the complementary “TEAMS 3.0” project where a more comprehensive training package was developed. The aim of this study was to assess the effectiveness and quality of the TEAMS 3.0 training package in four training programs in Portugal, Germany, Norway, and Turkey. Participants completed a set of questionnaires designed to assess self-efficacy, teamwork, and quality of training.ResultsThe results from all the trainings suggest an improvement for both teams’ self-efficacy and teamwork. The mean score among all the participants (N = 100) for both the self-efficacy scale and teamwork scale was 3.217 (±0.223) prior to training and 3.484 (±0.217) following the training, and 2.512 (±1.313) prior to training and 3.281 (±0.864), respectfully, with statistically significant differences according to Wilcoxon paired samples test (p &lt; 0.05). The quality of training is regarded as high and deemed as an appropriate tool package for addressing the objectives of the project and the perceived needs of EMT disaster deployment.ConclusionThus far, the TEAMS 3.0 project has demonstrated to be effective in promoting EMT teamwork capacities.
“Needed but lacked”: Exploring demand- and supply-side determinants of access to cardiopulmonary resuscitation training for the lay public in China
Authors: Dong Xuejie , Kong So Yeon Joyce , Xu Hanbing , Ho Andrew Fu Wah , Blewer Audrey L. , Birkenes Tonje Soraas , Myklebust Helge , Zheng Xiaojian , Li Minghua , Zheng Zhi-Jie , Zhang Zhifeng , Zhang Lin 
Published: April 2023

BackgroundDespite years of public cardiopulmonary resuscitation (CPR) training efforts, the training rate and survival following out-of-hospital cardiac arrest (OHCA) have increased modestly in China. Access is imperative to increase the public CPR training rate, which is determined by both demand- (e.g., the lay public) and supply-side (e.g., CPR trainers) factors. We aimed to explore the demand and supply determinants of access to CPR training for the lay public in China.MethodsQualitative semi-structured interviews were conducted with 77 laypeople (demand side) and eight key stakeholders from CPR training institutions (supply side) in Shanghai, China. The interview guide was informed by Levesque et al. healthcare access framework. Data were transcribed, quantified, described, and analyzed through thematic content analysis.ResultsOn the demand side, the laypeople's ability to perceive their need and willingness for CPR training was strong. However, they failed to access CPR training mainly due to the lack of information on where to get trained. Overestimation of skills, optimism bias, and misconceptions impeded laypeople from attending training. On the supply side, trainers were able to meet the needs of the trainees with existing resources, but they relied on participants who actively sought out and registered for training and lacked an understanding of the needs of the public for marketing and encouraging participation in the training.ConclusionInsufficient information and lack of initiative on the demand side, lack of motivation, and understanding of public needs on the supply side all contributed to the persistently low CPR training rate in China. Suppliers should integrate resources, take the initiative to increase the CPR training rate, innovate training modes, expand correct publicity, and establish whole-process management of training programs.
Spatio-temporal morphological variability of a tropical barrier island derived from the Landsat collection
Authors: Carvalho Breylla Campos , Gomes Carolina Lyra da Silva , Guerra Josefa Varela 
Published: April 2023

Barrier islands are low-lying elongated, narrow sandy deposits, usually parallel to the coastline, separated from the continent by a lagoon. Due to their low elevation above sea level, barrier islands are environments susceptible to drastic morphological changes depending on the meteo-oceanographic conditions to which they are subjected. This work presents the morphological changes between 1985 and 2021 in “Restinga da Marambaia”—a 40 km long barrier island on Brazil’s Southeastern coast. One hundred thirty-four scenes from the Landsat collection were processed, enabling the quantification of the barrier island area. Additionally, the rates of change in the position of the shorelines facing the Atlantic Ocean, Sepetiba Bay, and Marambaia Bay were computed. The barrier island’s total area and the central sector’s width present significant seasonal variability, which is maximum during the austral fall and winter seasons. On the shores facing the Atlantic Ocean and Sepetiba Bay, it is noted that the central and far eastern sectors show an erosional trend. In contrast, the coastline is more stable on the shore facing Marambaia Bay. The seasonal variations of the barrier island area occur during a period of low rainfall and more energetic waves associated with local winds, which produce coastal currents, transporting the available sediments.
Overcoming the efficiency paradigm—The challenges of introducing local organic beef in canteens
Authors: Schäfer Martina , Haack Michaela 
Published: April 2023

IntroductionIn recent years, there has been a growing recognition that public canteens can play an important role in supporting the transformation toward sustainable food systems and providing access to sustainable and healthy food for everybody—including the most vulnerable groups of the population. One important way in which canteens can contribute to this transformation is by increasing the share of organic and local products. These new political and public demands contrast with the organizational development of canteens over the past few decades, which has mainly been characterized by an increase in economic efficiency and a reduction in costs. Based on a project that was carried out in the Berlin-Brandenburg region (Germany), this paper exemplifies some of the challenges canteens face in the process of introducing organic and local products.MethodsThe empirical results are based on 31 qualitative interviews with canteen managers and kitchen staff as well as with the processing company involved. In addition, a survey of 500 canteen guests was conducted in the participating canteens.ResultsThe analysis shows that the canteens had to adapt various organizational practices to ensure a healthy and sustainable diet at manageable cost. Introducing local organic beef in the canteens requires close cooperation with local farmers and processors, a change in procurement practices, transparency around the origin of the products, as well as adapted menu planning.DiscussionBased on the empirical results, the paper discusses how these challenges can be met and which supportive measures can be taken on different governance levels. To change entrenched practices, process facilitators who support local cooperation along the value added chain are needed, and practical knowledge and professional training must be provided. The article concludes that there is a great potential to foster a sustainable and healthy diet via public and private canteens if the tension between efficiency and sustainability orientation can be overcome by adapting framework conditions.
Occurrence of intraocular hemorrhages under monotherapy or combination therapy of antiplatelets and anticoagulants using the Japanese Adverse Drug Event Report database
Authors: Tanaka Junko , Koseki Takenao , Sekido Kohsuke , Kimata Masashi , Ito Yasuki , Yamada Shigeki 
Published: April 2023

Purpose: An intraocular hemorrhage is an adverse event that can lead to visual acuity impairment. Antithrombotic therapy with antiplatelet agents and anticoagulants may increase intraocular hemorrhage. However, since their frequency is low, studies on the risk of intraocular hemorrhage with these drugs, especially under combination therapy, are limited. This study aimed to investigate the occurrence of intraocular hemorrhages under monotherapy and combination therapy with antiplatelets and anticoagulants by analyzing a large pharmacovigilance database.Methods: Intraocular hemorrhage signals with oral antiplatelets and anticoagulants were evaluated by calculating reporting odds ratios and information components using the Japan Adverse Drug Reactions Report database from April 2004 to March 2022. In addition, differences in signals between younger and elderly patients, affecting factors, and time-to-onset from initial antiplatelet and anticoagulant treatments were analyzed.Results: Aspirin, clopidogrel, warfarin, apixaban, and rivaroxaban, but not ticagrelor, ticlopidine, prasugrel, dabigatran, and edoxaban showed intraocular hemorrhage signals under monotherapy. In combination therapy, dual therapy (aspirin + P2Y12 inhibitors, warfarin, direct oral anticoagulants, and P2Y12 inhibitors + warfarin) and triple therapy (aspirin + P2Y12 inhibitors + warfarin) resulted in intraocular hemorrhage signals. Intraocular hemorrhage signals were observed in younger patients receiving monotherapy with aspirin and in elderly patients receiving monotherapy and combination therapy with warfarin. Affecting factors were diabetes mellitus in patients with prasugrel, use of medications for intravitreal injections, and posterior sub-Tenon injections with some antiplatelets and anticoagulants. The median period of intraocular hemorrhage occurrence after starting monotherapy with aspirin, clopidogrel, warfarin, or rivaroxaban was within 90 days.Conclusion: In addition to monotherapy with several antiplatelets and anticoagulants, combination therapy using aspirin, P2Y12 inhibitors, and warfarin has the potential risk of intraocular hemorrhage. Particular attention should be paid to the occurrence of intraocular hemorrhages in younger patients taking aspirin, in elderly patients taking warfarin, and within the first 90 days of antiplatelet and anticoagulant use.