bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic models for outcome prediction following in-hospital cardiac arrest using pre-arrest factors: a systematic review, meta-analysis and critical appraisal
Authors: Grandbois van Ravenhorst Casey , Schluep Marc , Endeman Henrik , Stolker Robert-Jan , Hoeks Sanne Elisabeth 
Published: January 2023

Abstract
Background
Several prediction models of survival after in-hospital cardiac arrest (IHCA) have been published, but no overview of model performance and external validation exists. We performed a systematic review of the available prognostic models for outcome prediction of attempted resuscitation for IHCA using pre-arrest factors to enhance clinical decision-making through improved outcome prediction.

Methods
This systematic review followed the CHARMS and PRISMA guidelines. Medline, Embase, Web of Science were searched up to October 2021. Studies developing, updating or validating a prediction model with pre-arrest factors for any potential clinical outcome of attempted resuscitation for IHCA were included. Studies were appraised critically according to the PROBAST checklist. A random-effects meta-analysis was performed to pool AUROC values of externally validated models.

Results
Out of 2678 initial articles screened, 33 studies were included in this systematic review: 16 model development studies, 5 model updating studies and 12 model validation studies. The most frequently included pre-arrest factors included age, functional status, (metastatic) malignancy, heart disease, cerebrovascular events, respiratory, renal or hepatic insufficiency, hypotension and sepsis. Only six of the developed models have been independently validated in external populations. The GO-FAR score showed the best performance with a pooled AUROC of 0.78 (95% CI 0.69–0.85), versus 0.59 (95%CI 0.50–0.68) for the PAM and 0.62 (95% CI 0.49–0.74) for the PAR.

Conclusions
Several prognostic models for clinical outcome after attempted resuscitation for IHCA have been published. Most have a moderate risk of bias and have not been validated externally. The GO-FAR score showed the most acceptable performance. Future research should focus on updating existing models for use in clinical settings, specifically pre-arrest counselling.
Systematic review registration PROSPERO CRD42021269235. Registered 21 July 2021.
Periodontal therapy for localized severe periodontitis in a patient receiving fixed orthodontic treatment: a case report
Authors: Morikawa Satoru , Watanabe Kazuya , Otsuka Ryo , Asoda Seiji , Nakagawa Taneaki 
Published: January 2023

Abstract
Background
Orthodontic treatment involves movement of teeth by compression and resorption of the alveolar bone using orthodontic forces. These movements are closely linked to the interactions between the teeth and the periodontal tissues that support them. Owing to an increase in adults seeking orthodontic treatment, orthodontists increasingly encounter patients with periodontal diseases, in whom orthodontic treatment is contraindicated. In rare cases, periodontitis may develop after treatment initiation. However, no approach for treating periodontitis after the initiation of orthodontic treatment has been established. Here, we present an approach for managing localized severe periodontitis manifesting after initiating orthodontic treatment.

Case presentation
A 32-year-old Japanese woman was referred to the Department of Dentistry and Oral Surgery by an orthodontist who observed symptoms of acute periodontitis in the maxillary molars that required periodontal examination and treatment. A detailed periodontal examination, including oral bacteriological examination, revealed localized severe periodontitis (stage III, grade B) in the maxillary left first and second molars and in the mandibular right second molar. After consultation with the orthodontist, the orthodontic treatment was suspended based on the results of the bacteriological examination to allow for periodontal treatment. Full-mouth disinfection was performed with adjunctive oral sitafloxacin. Periodontal and bacteriological examinations after treatment revealed regression of the localized periodontitis with bone regeneration. Thereafter, orthodontic treatment was resumed, and good progress was achieved.

Conclusions
Orthodontists should recognize the risk of acute severe periodontitis in young adults. Asymptomatic patients with localized severe periodontitis may clear a screening test before orthodontic treatment but develop acute symptoms with bone resorption during orthodontic treatment. Therefore, patients requiring orthodontic treatment should be examined by their family dentist or a periodontist to rule out periodontal issues that may impede orthodontic treatment. The patients should also be informed of age-related risks. Further, periodontists, family dentists, and orthodontists who treat adults should be informed about periodontitis and the need for interdisciplinary collaboration. In patients who develop periodontitis after orthodontic treatment initiation, temporary interruption of orthodontic treatment and aggressive periodontal intervention may facilitate recovery.
A First-in-Human Phase I Study of Milademetan, an MDM2 Inhibitor, in Patients With Advanced Liposarcoma, Solid Tumors, or Lymphomas
Authors: Gounder Mrinal M. , Bauer Todd M. , Schwartz Gary K. , Weise Amy M. , LoRusso Patricia , Kumar Prasanna , Tao Ben , Hong Ying , Patel Parul , Lu Yasong , Lesegretain Arnaud , Tirunagaru Vijaya G. , Xu Feng , Doebele Robert C. , Hong David S. 
Published: January 2023

PURPOSE This study evaluated the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of milademetan, a small-molecule murine double minute-2 (MDM2) inhibitor, in patients with advanced cancers. PATIENTS AND METHODS In this first-in-human phase I study, patients with advanced solid tumors or lymphomas received milademetan orally once daily as extended/continuous (days 1-21 or 1-28 every 28 days) or intermittent (days 1-7, or days 1-3 and 15-17 every 28 days) schedules. The primary objective was to determine the recommended phase II dose and schedule. Secondary objectives included tumor response according to standard evaluation criteria. Predefined analyses by tumor type were performed. Safety and efficacy analyses included all patients who received milademetan. RESULTS Between July 2013 and August 2018, 107 patients were enrolled and received milademetan. The most common grade 3/4 drug-related adverse events were thrombocytopenia (29.0%), neutropenia (15.0%), and anemia (13.1%). Respective rates at the recommended dose and schedule (260 mg once daily on days 1-3 and 15-17 every 28 days, ie, 3/14 days) were 15.0%, 5.0%, and 0%. Across all cohorts (N = 107), the disease control rate was 45.8% (95% CI, 36.1 to 55.7) and median progression-free survival was 4.0 months (95% CI, 3.4 to 5.7). In the subgroup with dedifferentiated liposarcomas, the disease control rate and median progression-free survival were 58.5% (95% CI, 44.1 to 71.9) and 7.2 months overall (n = 53), and 62.0% (95% CI, 35.4 to 84.8) and 7.4 months with the recommended intermittent schedule (n = 16), respectively. CONCLUSION An intermittent dosing schedule of 3/14 days of milademetan mitigates dose-limiting hematologic abnormalities while maintaining efficacy. Notable single-agent activity with milademetan in dedifferentiated liposarcomas has prompted a randomized phase III trial (MANTRA).
Associations of Early Completion of Advance Directives With Key End-of-Life Quality Measures: Analysis of an ASCO Quality Oncology Practice Initiative Patient Cohort
Authors: Power Steve , Bickel Kathleen , Chen Ronald C. , Chiang Anne C. , Garrett-Mayer Liz , Makhoul Issam , Mougalian Sarah S. , Shapiro Charles L. , Siegel Robert , Smith Cardinale , Rocque Gabrielle B. , Kozlik Mary May , Crist Stéphanie T.S. , Kamal Arif 
Published: January 2023

PURPOSE: Despite the growing calls for early and ubiquitous completion of advance directives (ADs), studies exploring links between AD completion and their impact on outcomes of patients with cancer have mixed conclusions. We used the ASCO Quality Oncology Practice Initiative (QOPI) registry to compare end-of-life (EOL) quality measures and the effect of QOPI certification among patients with and without early AD completion, defined as completion within the first three oncology visits after cancer diagnosis. METHODS: Deidentified patient-level data were analyzed from the QOPI database from 2015 through 2017. Associations were assessed using Chi-square tests between early AD completion and patient enrollment in hospice < 7 days before death, chemotherapy receipt in the last 14 days of life, or with emergency room visits or intensive care unit admissions in the last 30 days of life. RESULTS: Data from 31,558 patients eligible for the AD question were analyzed. Patients treated at QOPI-certified practices had higher rates of early AD completion than patients at non-certified practices. Early AD completion was not associated with differences in hospice enrollment for < 7 days before death, chemotherapy receipt in the last 14 days of life, or emergency room visits or intensive care unit encounters in the last 30 days of life. CONCLUSION: The study found that QOPI certification is associated with higher rates of early AD completion. However, early AD completion was not associated with recognized EOL quality measures. Future research should focus on the timing, frequency, and content of AD conversations to demonstrate the impact on care at the EOL.
Approach to the Patient: Pharmacological Therapies for Fracture Risk Reduction in Adults With Osteogenesis Imperfecta
Authors: Liu Winnie , Lee Brendan , Nagamani Sandesh C S , Nicol Lindsey , Rauch Frank , Rush Eric T , Sutton V Reid , Orwoll Eric 
Published: January 2023

Abstract

Context
Osteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone fragility largely caused by defects in structure, synthesis, or post-translational processing of type I collagen. The effectiveness of medications used for fracture reduction in adults with OI is understudied and practice recommendations are not well established. Drugs currently used to improve skeletal health in OI were initially developed to treat osteoporosis. Oral and intravenous bisphosphonates have been shown to improve bone mineral density (BMD) in adults with OI and are commonly used; however, conclusive data confirming fracture protection are lacking. Similarly, teriparatide appears to increase BMD, an effect that seems to be limited to individuals with type I OI. The role of denosumab, abaloparatide, romosozumab, and estradiol/testosterone in adult OI have not been systematically studied. Anti-sclerostin agents and transforming growth factor-beta antagonists are under investigation in clinical trials.

Objective
This review summarizes current knowledge on pharmacologic treatment options for reducing fracture risk in adults with OI.

Methods
A PubMed online database search of all study types published in the English language using the terms “osteogenesis imperfecta,” “OI,” and “brittle bone disease” was performed in June 2022. Articles screened were restricted to adults. Additional sources were identified through manual searches of reference lists.

Conclusion
Fracture rates are elevated in adults with OI. Although clinical trial data are limited, bisphosphonates and teriparatide may be useful in improving BMD. Further research is needed to develop medications for adults with OI that will lead to definite fracture rate reduction.
The Message of “Chèvrefeuille”
Authors: Levine Kathryn E. 
Published: January 2023

AbstractThe apparent ambiguity at the heart of Marie de France’s lai “Chèvrefeuille” has beguiled generations of readers. This short twelfth-century Old French verse text purports to tell a simple story of how the exiled Tristan manages to signal to Yseut as she passes through a forest with her entourage, and its only interpretive difficulty seems to be the way Tristan communicates his message by carving some words or letters onto a stick. This article argues that, by debating what exactly Tristan writes, the scholarship on “Chèvrefeuille” leaves aside the intertext of the Tristan tradition, and by extension, the literary and affective investments of the lai. This narrow critical question leads to a broader problem of how literature can or should be read. Reading “Chèvrefeuille” as imbricated in the twelfth-century Tristan tradition underscores the pleasure of recognition that both modern reader and medieval receiver might experience and invites a re-examination of the role of the imagination in the study of medieval literature.
Racial/Ethnic Variation in the Relationship Between Educational Assortative Mating and Wives' Income Trajectories
Authors: Choi Kate H. , Denice Patrick 
Published: January 2023

AbstractPrior work has examined the relationship between educational assortative mating and wives' labor market participation but has not assessed how this relationship varies by race/ethnicity. Using data from the National Longitudinal Survey of Youth 1979, we estimate group-based developmental trajectories to investigate whether the association between educational assortative mating and wives' income trajectories varies by race/ethnicity. The presence, prevalence, and shapes of prototypical long-term income trajectories vary markedly across racial/ethnic groups. Whites are more likely than Blacks and Hispanics to follow income trajectories consistent with a traditional gender division of labor. The association between educational assortative mating is also stronger for Whites than for Blacks and Hispanics. White wives in educationally hypogamous unions make the greatest contribution to the couple's total income, followed by those in homogamous and hypergamous unions. Black and Hispanic wives in hypogamous unions are less likely than their peers in other unions to be secondary earners. These findings underscore the need for studies of the consequences of educational assortative mating to pay closer attention to heterogeneity across and within racial/ethnic groups.
Educating for Wisdom through Literary Study
Authors: Bracher Mark 
Published: January 2023

AbstractIn response to an urgent need for better decision making in the public sphere, this article presents a method by which literary study can cultivate wisdom, defined as the ability to respond to problems with courses of action that maximize flourishing and minimize harm for all parties, both now and in the future. Drawing on the latest evidence-based learning principles, the article explains the pedagogical strategies and practices by which four wisdom-constituting thinking skills can be developed.
Why Does a Failed Revolution Also Need Fiction?
Authors: Chew Ng Kim , Chen Po-Hsi 
Published: January 2023

Abstract
The historical relationship between the categories of Malayan Communist fiction and People's Republic of China revolutionary historical fiction remains to be clarified, just as the Malayan Communist revolution was covertly, but undeniably, connected to the Chinese Communist Party. This essay attempts to take the PRC's revolutionary historical fiction as a reference point to reinvestigate Malayan Communist fiction, which was characterized as “historical fiction” by left-wing writers. Examples include Jin Zhimang's Hunger, Liu Jun's Wind Blowing in the Woods, and Tuo Ling's The Hoarse Mangrove Forest. The key issue is that the PRC's revolutionary historical fiction is premised on triumphalism, to authenticate the revolution's legitimacy, while Malayan Communists' revolutionary historical fiction hinges instead on the failure of revolution—though it cannot be recognized as such. How do these latter works contemplate and represent revolution? Does fiction have to rationalize the legitimacy of a failed revolution (or one mired in predicaments)? Or does fiction attempt to accomplish something else? These questions may concern the raison d’être of Malayan Chinese literary realism, which takes representing reality as its mission and investigates its underlying paradoxes.
The centralspindlin complex regulates cytokinesis and morphogenesis in the C. elegans spermatheca
Authors: Zhang Pei , Chen Jiwei , Wang Xiangchuan , Geng Yingchao , Sun Liangyu , Zhang Hongjie 
Published: January 2023

ABSTRACT
Organ morphogenesis needs orchestration of a series of cellular events, including cell division, cell shape change, cell rearrangement and cell death. Cytokinesis, the final step of cell division, is involved in the control of organ size, shape and function. Mechanistically, it is unclear how the molecules involved in cytokinesis regulate organ size and shape. Here, we demonstrate that the centralspindlin complex coordinates cell division and epithelial morphogenesis by regulating cytokinesis. Loss of the centralspindlin components CYK-4 and ZEN-4 disrupts cell division, resulting in altered cell arrangement and malformation of the Caenorhabditis elegans spermatheca. Further investigation revealed that most spermathecal cells undergo nuclear division without completion of cytokinesis. Germline mutant-based analyses suggest that CYK-4 regulates cytokinesis of spermathecal cells in a GTPase activator activity-independent manner. Spermathecal morphology defects can be enhanced by double knockdown of rho-1 and cyk-4, and partially suppressed by double knockdown of cdc-42 and cyk-4. Thus, the centralspindlin components CYK-4 and ZEN-4, together with RHO-1 and CDC-42, are central players of a signaling network that guides spermathecal morphogenesis by enabling completion of cytokinesis.
Multi-harmonic reconstruction of photoelastic modulator-based Mueller polarimeters using the complex Q-matrix
Authors: Kurtz Joe , Alenin Andrey S. , Tyo J. Scott 
Published: January 2023

Analysis of data generated by Mueller matrix polarimeters using two photoelastic modulators has been evolving with the improvements in data acquisition and digital signal processing (DSP). Historical processing of the temporal data generated by these devices has involved isolating the frequencies via hardware signal processing (e.g., lock-in amplifiers) or the numerical computation of Fourier integrals of recorded temporal data. Both avenues have their advantages, but the DSP aspects of the latter provide greater flexibility in choice of harmonics for processing. While conventional processing uses one harmonic for each desired Mueller matrix element, recent work has demonstrated that theoretical improvements are possible by coherently combining the information in multiple harmonic channels for each element. We demonstrate some recent progress in DSP that enables these polarimeters’ data to be more fully exploited by addressing two key issues in the Fourier domain: spectral leakage and phase recovery. Adequately addressing these issues enables numerical analysis of the temporal data in the complex Fourier domain and delivers Mueller matrix results in which spectral phase information is used to recover the matrix elements and determine their signs automatically. We explore the application of this complex analysis and how the precision and accuracy of the results are affected by common experimental and DSP limitations compared to the usual magnitude-only analysis in the Fourier domain. The multi-harmonic method can provide a theoretical factor of 1.3–1.7 improvement in instrumental precision, and our experimental results approach that theoretical range.
Recent progress in high-speed laser diagnostics for hypersonic flows [Invited]
Authors: Jiang Naibo , Hsu Paul S. , Gragston Mark , Roy Sukesh 
Published: January 2023

The recent progress in high-speed (

≥

100

k
H
z

) laser diagnostics for hypersonic
flows is reviewed. Owing to the ultrahigh flow speed, a laser
frequency of 100 kHz or higher is required for hypersonic diagnostics.
Here, two main laser diagnostic techniques are discussed: focused
laser differential interferometry (FLDI) and pulse-burst laser-based
diagnostics. Single- and multiple-point FLDI measurements have been
widely applied to hypersonic flows for flow velocity and density
fluctuation measurements. The progress of pulse-burst laser-based
hypersonic diagnostics, including flow velocity measurements and 2D
flow visualization, is also discussed.
Serological evidence of Yersinia pestis infection in rodents and carnivores in Northwestern Iran
Authors: Esmaeili Saber , Esmaeili Parisa , Mahmoudi Ahmad , Ghasemi Ahmad , Mohammadi Ali , Bagheri Amin , Sohrabi Aria , Rezaei Farshid , Hanifi Hamed , Neamati Amir Hesam , Gouya Mohammad Mehdi , Mostafavi Ehsan 
Published: January 2023

BackgroundPlague may recur after several decades in its endemic regions; therefore, the continuous monitoring of wildlife is essential, even when no human cases are reported in the old foci. The present study was conducted to monitor rodents and their ectoparasites as well as carnivores to learn about the epidemiology of plague infection in an old focus of Iran.MethodologyThe present study was conducted from 2019 to 2020 in Takestan county of Qazvin Province in northwestern Iran. Rodents were caught using live traps, and their fleas were separated. Blood and spleen specimens were taken from the captured rodents. Serum samples were also collected from sheepdogs and wild carnivores. The collected samples were tested by culture, serology (ELISA), and molecular methods to detectYersinia pestisinfection.FindingsA total of 399 small mammals were caught, of which 68.6% wereMeriones persicus. A total of 2438 fleas were collected from the rodents, 95.3% of which wereXenopsylla buxtoni. Overall, 23 out of 377 tested rodents (5.7%, CI 95%, 3.9–9.0) had IgG antibodies against theF1antigen ofY.pestis, and all the positive samples belonged toM.persicus. Nine (4.8%) out of 186 collected sera from the sheepdogs’ serum and one serum from theCanis aureushad specific IgG antibodies against theF1antigen ofY.pestis. There were no positive cases ofY.pestisin the rodents and fleas based on the culture and real-time PCR.ConclusionSerological evidence ofY.pestiscirculation was observed in rodents and carnivores (sheepdogs andC.aureus). The presence of potential plague vectors and serological evidence ofY.pestisinfection in the surveyed animals could probably raise the risk of infection and clinical cases of plague in the studied region. Training health personnel is therefore essential to encourage their detection of possible human cases of the disease.