bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective quantitative risk assessment of skin sensitization caused by an antimicrobial agent used in a consumer product: 2,3,5,6‐Tetrachloro‐4‐(methylsulfonyl) pyridine
Authors: Fukushima Asako , Morioka Hisako , Kobayashi Toshio , Katagiri Ritsuko , Tanabe Aiko , Sakunaga Mayumi , Takeyoshi Masahiro 
Published: February 2023

AbstractBackgroundSerious cases of allergic contact dermatitis (ACD) caused by exposure to 3,5,6‐tetrachloro‐4‐(methylsulfonyl)pyridine (TCMSP; CAS no. 13108‐52‐6) used as an antimicrobial agent for desk mats have been reported in Japan.ObjectiveA quantitative risk assessment (QRA) of TCMSP contained in desk mats was performed retrospectively.Materials and MethodsA local lymph node assay (LLNA): BrdU‐ELISA was conducted to determine a reliable EC1.6 value for TCMSP. The acceptable exposure level (AEL) for TCMSP was derived from the EC1.6 value by applying sensitization assessment factors (SAFs). The exposure level was estimated based on the assumption referring to the use conditions of thiabendazole in the same purpose. Then, the estimated exposure level was compared with the AEL to evaluate the skin sensitization risk.ResultsThe AEL was calculated as 0.00458 μg/cm2 based on the EC1.6 value (0.011%, 2.75 μg/cm2) by applying a composite SAF of 600. The estimated TCMSP exposure level from the desk mat was 500 times greater than the AEL, indicating a serious skin sensitization risk.ConclusionsAssessments of skin sensitization potencies of chemicals to be used in consumer products are strongly recommended, and QRAs should be performed at the pre‐marketing stage to avoid the skin sensitization risk in consumers.
Tetrahedral framework nucleic acid nanomaterials reduce the inflammatory damage in sepsis by inhibiting pyroptosis
Authors: Chen Xingyu , He Jiajun , Xie Yu , Zhang Tianxu , Li Songhang , Zhao Yuxuan , Hu Nan , Cai Xiaoxiao 
Published: February 2023

AbstractSepsis is a highly lethal condition and is caused by the dysregulation of the body's immune response to infection. Indeed, sepsis remains the leading cause of death in severely ill patients, and currently, no effective treatment is available. Pyroptosis, which is mainly activated by cytoplasmic danger signals and eventually promote the release of the pro‐inflammatory factors, is a newly discovered programmed cell death procedure that clears infected cells while simultaneously triggering an inflammatory response. Increasing evidence indicates that pyroptosis participates in the development of sepsis. As a novel DNA nanomaterial, tetrahedral framework nucleic acids (tFNAs) characterized by its unique spatial structure, possess an excellent biosafety profile and can quickly enter the cell to impart anti‐inflammatory and anti‐oxidation effects. In this study, the roles of tFNAs in the in vitro model of macrophage cell pyroptosis and in the in vivo model of septic mice were examined, and it was found that tFNAs could mitigate organ inflammatory damage in septic mice, wherein they reduced inflammatory factor levels by inhibiting pyroptosis. These results provide possible new strategies for the future treatment of sepsis.
Clinical features of asthma with connective tissue diseases
Authors: Watanabe Keisuke , Horita Nobuyuki , Hara Yu , Kobayashi Nobuaki , Kaneko Takeshi 
Published: February 2023

AbstractBackgroundThe clinical features of asthma with connective tissue diseases (CTDs) are not well‐known. This study therefore aimed to investigate the clinical characteristics of asthma with CTDs.MethodsWe retrospectively examined the records of adults (≥18 years old) with asthma followed up between January 2010 and December 2019. We then compared the clinical features of asthma with and without CTDs.ResultsAmong 568 subjects with asthma, 42 subjects (7.4%) had CTDs. The most frequent concomitant CTD was rheumatoid arthritis (n = 23, 54.8%), followed by systemic lupus erythematosus (n = 6, 14.3%). The proportion of women (with vs. without CTDs, 85.7% vs. 56.5%, p < 0.001) and Global Initiative for Asthma step were higher (Step 4 or 5, with vs. without CTDs, 81.0% vs. 62.0%, p = 0.01) in asthma with CTDs, whereas frequency of allergic rhinitis was higher in asthma without CTDs (with vs. without CTDs, 7.1% vs. 26.1%, p = 0.005). Eosinophil ratio (with vs. without CTDs, 2.1% vs. 3.5%, p = 0.009) and total immunoglobulin E level (with vs. without CTDs, 43 IU/mL vs. 237 IU/mL, p = 0.002) were lower in asthma with CTDs. In terms of lung function, percentage predicted forced vital capacity (with vs. without CTDs, 86.7% vs. 99.7%, p = 0.008) and percentage predicted forced expiratory volume in 1 s (%FEV1) (with vs. without CTDs, 77.2% vs. 88.4%, p = 0.02) were all lower in asthma with CTDs. With multivariable analysis, CTDs (odds ratio [OR] 2.8, 95%CI 1.3–6.0; p = 0.008), chronic obstructive pulmonary disease (OR 3.8, 95%CI 2.1–6.7; p < 0.001) and asthma onset at <20 years old (OR 1.8, 95%CI 1.1–3.2; p = 0.03) were associated with low FEV1 (defined as %FEV1 < 80%) in asthma.ConclusionsAsthma with CTDs was related to lower lung function and low‐T2 inflammation asthma.
First Wave Collecting – Christchurch Terror Attacks, 15 March 2019
Authors: Gibson Stephanie , Blaymires Shannon 
Published: February 2023

AbstractThis paper explores how the Museum of New Zealand Te Papa Tongarewa and Alexander Turnbull Library (a division of the National Library of New Zealand Te Puna Mātauranga o Aotearoa) responded to the outpouring of grief in the wake of the Christchurch terror attacks on 15 March 2019. This case study highlights how both institutions, at the invitation of the Wellington Islamic Centre (through the International Muslim Association of New Zealand) collected the hundreds of tributes left at Kilbirnie Mosque in Wellington. This particular acquisition required a shift from a museological object‐centred approach to an archival approach, enabling us to privilege the integrity of the whole. The authors consider the meanings and impacts of such spontaneous memorials; and discuss both the benefits and limitations of collecting material culture generated by ‘first wave’ responses to mass trauma. This case study also demonstrates what can be achieved through collaboration, drawing on aspects of professional practice and theory from across the GLAM (Galleries, Libraries, Archives and Museums) sector.
COVID‐19 post‐vaccination lymphadenopathy: A review of the use of fine needle aspiration cytology
Authors: Caputo Alessandro , Caleo Alessia , Cozzolino Immacolata , Zeppa Pio , Ciancia Giuseppe , Ciliberti Valeria 
Published: February 2023

AbstractCOVID‐19 vaccine‐associated clinical lymphadenopathy (C19‐LAP) and subclinical lymphadenopathy (SLDI), which are mainly detected by 18F‐FDG PET‐CT, have been observed after the introduction of RNA‐based vaccines during the pandemic. Lymph node (LN) fine needle aspiration cytology (FNAC) has been used to diagnose single cases or small series of SLDI and C19‐LAP. In this review, clinical and LN‐FNAC features of SLDI and C19‐LAP are reported and compared to non‐Covid (NC)‐LAP. A search for studies on C19‐LAP and SLDI histopathology and cytopathology was performed on PubMed and Google Scholar, on 11 January 2023. Reports on LN‐FNAC of C19‐LAP were retrieved. A total of 14 reports, plus one unpublished case of C19‐LAP observed in our institution, diagnosed by LN‐FNAC were included in a pooled analysis and compared to the corresponding histopathological reports. In total, 26 cases were included in this review, with a mean age of 50.5 years. Twenty‐one lymphadenopathies assessed by LN‐FNAC were diagnosed as benign, and three cases as atypical lymphoid hyperplasia; the latter were subsequently confirmed as benign (one by repetition of LN‐FNAC, two by histological control). One case of mediastinal lymphadenopathy in a patient suffering from melanoma was reported as reactive granulomatous inflammation, while one unsuspected case was diagnosed as metastasis from melanoma. In all cases, the cytological diagnoses were confirmed by follow‐up or excisional biopsy. The high diagnostic value of LN‐FNAC in excluding malignant processes was extremely useful in this context and may be particularly valuable when CNB or histological excisions are difficult to perform, as was the case during Covid lockdowns.
Small area and low connectivity constrain the diversity of plant life strategies in temporary ponds
Authors: Herceg‐Szórádi Zsófia , Demeter László , Csergő Anna Mária 
Published: February 2023

AbstractAim(i) To determine whether area and connectivity of temporary ponds can predict plant species diversity, and the diversity and abundance of different plant life histories; (ii) To explore whether pond connectivity with the river prior to river regulation predicts better plant diversity patterns than current pond connectivity, suggestive of possible effects of connectivity loss.LocationEastern Carpathian Mountains, Romania, Europe.MethodsWe fitted linear and generalized linear models (LM and GLM) to examine whether pond area and current distance from the Olt River predict plant species richness, Shannon diversity and relative cover of different social behaviour types and overall plant species richness and Shannon diversity. Using historical maps, we measured pond distance from the river ca. 60 years before the Olt River was regulated, and we refitted the LM and GLM models using pond area and past distance from the river as independent variables.ResultsTotal plant species richness increased with pond area, and it decreased with the distance from the river, but total plant Shannon diversity index was affected, positively, only by pond area. The strength of responses to pond area and connectivity of species richness, Shannon diversity and relative cover varied across the different social behaviour types. Past and current distances between ponds and riverbeds had similar effects on plant diversity, with some evidence for stronger effect of the present connectivity on specialist species Shannon diversity and a weaker effect on disturbance tolerants, generalists and competitors.Main ConclusionsPond area and connectivity with the landscape are important predictors of the diversity of plant life history strategies, and therefore, useful tools in pond conservation. Consistent species richness and Shannon diversity responses of wetland specialists to pond area and connectivity make this life history type well suited for monitoring pond condition.
Blue light imaging and linked color imaging as a screening mode for esophageal squamous cell carcinoma in high‐risk patients: Multicenter randomized trial
Authors: Ogata Yohei , Hatta Waku , Koike Tomoyuki , Takahashi So , Matsuhashi Tamotsu , Oikawa Tomoyuki , Iwai Wataru , Asonuma Sho , Okata Hideki , Ohyauchi Motoki , Ito Hirotaka , Abe Yasuhiko , Sasaki Yu , Kawamura Masashi , Saito Masahiro , Uno Kaname , Fujishima Fumiyoshi , Nakamura Tomohiro , Nakaya Naoki , Iijima Katsunori , Masamune Atsushi 
Published: February 2023

ObjectivesBlue light imaging (BLI) and linked color imaging (LCI) are superior to conventional white light imaging for detecting esophageal squamous cell carcinoma (ESCC). Hence, we compared their diagnostic performances in ESCC screening.MethodsThis open‐labeled, randomized controlled trial was performed at seven hospitals. Patients with a high risk of ESCC were randomly assigned to the BLI group (BLI followed by LCI) and LCI group (LCI followed by BLI). The primary end‐point was the detection rate of ESCC in the primary mode. The main secondary end‐point was its miss rate in the primary mode.ResultsIn total, 699 patients were enrolled. The detection rate of ESCC did not significantly differ between the BLI and LCI groups (4.0% [14/351] vs. 4.9% [17/348]; P = 0.565); however, the number of patients with ESCC tended to be smaller in the BLI group (19 vs. 30). Notably, the miss rate of ESCC was lower in the BLI group (26.3% [5/19] vs. 63.3% [19/30]; P = 0.012) and LCI detected no ESCCs missed by BLI. The sensitivity was higher in BLI (75.0% vs. 47.6%; P = 0.042); on the other hand, the positive predictive value in BLI tended to be lower (28.8% vs. 45.5%; P = 0.092).ConclusionsThe detection rates of ESCC did not significantly differ between BLI and LCI. Although BLI may have the potential to be advantageous over LCI for the diagnosis of ESCC, it is still unclear whether BLI is superior to LCI, and a further large‐scale study is needed.Trial registrationJapan Registry of Clinical Trials (jRCT1022190018‐1).
Exposure to endocrine‐disrupting chemicals and implications for neurodevelopment
Authors: Özel Fatih , Rüegg Joëlle 
Published: February 2023

AbstractHuman brain development is a complex multistep process that is partly coordinated by the endocrine system. Any interference with the endocrine system might affect this process and result in deleterious outcomes. Endocrine‐disrupting chemicals (EDCs) represent a large group of exogenous chemicals with the capacity of interfering with endocrine functions. In different population‐based settings, associations between exposure to EDCs, particularly in prenatal life, and adverse neurodevelopmental outcomes have been demonstrated. These findings are strengthened by numerous experimental studies. Although mechanisms underlying these associations are not entirely delineated, disruption of thyroid hormone and, to a lesser extent, sex hormone signalling have been shown to be involved. Humans are constantly exposed to mixtures of EDCs, and further research combining epidemiological and experimental settings is required to improve our understanding of the link between real‐life exposures to these chemicals and their impact on neurodevelopment.
Sudden unexpected death in epilepsy in children
Authors: Whitney Robyn , Sharma Suvasini , Ramachandrannair Rajesh 
Published: February 2023

AbstractSudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy‐related mortality in children and adults living with epilepsy. The incidence of SUDEP is comparable in both children and adults; it is approximately 1.2 per 1000 person years. The pathophysiology of SUDEP is not well understood but may involve mechanisms such as cerebral shutdown, autonomic dysfunction, altered brainstem function, and cardiorespiratory demise. Risk factors for SUDEP include the presence of generalized tonic–clonic seizures, nocturnal seizures, possible genetic predisposition, and non‐adherence to antiseizure medications. Pediatric‐specific risk factors are not fully elucidated. Despite recommendations from consensus guidelines, many clinicians still do not follow the practice of counseling their patients about SUDEP. SUDEP prevention has been an area of important research focus and includes several strategies, such as obtaining seizure control, optimizing treatment regimens, nocturnal supervision, and seizure detection devices. This review discusses what is currently known about SUDEP risk factors and reviews current and future preventive strategies for SUDEP.
Healthcare professionals' views about how pregnant women can benefit from using a closed‐loop system: Qualitative study
Authors: Lawton Julia , Rankin David , Hartnell Sara , Lee Tara , Dover Anna R. , Reynolds Rebecca M. , Hovorka Roman , Murphy Helen R. , Hart Ruth I. ,   the AiDAPT Collaborative Group
Published: February 2023

AbstractBackgroundInterest is growing in how closed‐loop systems can support attainment of within‐target glucose levels amongst pregnant women with type 1 diabetes. We explored healthcare professionals' views about how, and why, pregnant women benefitted from using the CamAPS FX system during the AiDAPT trial.MethodsWe interviewed 19 healthcare professionals who supported women using closed‐loop during the trial. Our analysis focused on identifying descriptive and analytical themes relevant to clinical practice.ResultsHealthcare professionals highlighted clinical and quality‐of‐life benefits to using closed‐loop in pregnancy; albeit, they attributed some of these to the continuous glucose monitoring component. They emphasised that the closed‐loop was not a panacea and that, to gain maximum benefit, an effective collaboration between themselves, the woman and the closed‐loop was needed. Optimal performance of the technology, as they further noted, also required women to interact with the system sufficiently, but not excessively; a requirement that they felt some women had found challenging. Even where healthcare professionals felt that this balance was not achieved, they suggested that women had still benefitted from using the system. Healthcare professionals reported difficulties predicting how specific women would engage with the technology. In light of their trial experiences, healthcare professionals favoured an inclusive approach to closed‐loop rollout in routine clinical care.ConclusionsHealthcare professionals recommended that closed‐loop systems be offered to all pregnant women with type 1 diabetes in the future. Presenting closed‐loop systems to pregnant women and healthcare teams as one pillar of a three‐party collaboration may help promote optimal use.
Exploring SME environmental behaviour and practice: The case of Malaysia
Authors: Baskaran Angathevar , Chandran V. G. R. , Rajaghantham Divyaasiny 
Published: February 2023

AbstractMotivationA better understanding of the dynamics of the factors that influence the environmental behaviour of small and medium‐sized enterprises (SMEs) in Malaysia is crucial for new policy experiments.PurposeWe examine the drivers, barriers, and incentives of SMEs in adopting environmental practices and reporting, as well as the dynamics driving SME decision‐making in Malaysia.Methods and approachThis article uses multiple case studies and semi‐structured interviews as the qualitative methodology is best suited to gain an in‐depth understanding of SME experiences and perceptions.FindingsSMEs have adopted several environmental practices, and few have already engaged in environmental reporting, albeit at varying levels. The perceived reputation‐enhancing and knowledge‐disseminating results are a strong incentive for SMEs. Interestingly, SMEs' decision to adopt environmental practices and reporting is driven by multiple factors, leaving more room for policy experimentation, as our dynamic interaction matrix shows.Policy implicationsComprehensive environmental practices and reporting by SMEs is feasible if policy design considers the dynamics of regulatory pressures, key drivers, and perceived incentives.
The urotensin‐II receptor: A marker for staging and steroid outcome prediction in ulcerative colitis
Authors: Gravina Antonietta Gerarda , Dallio Marcello , Romeo Mario , Pellegrino Raffaele , Stiuso Paola , Lama Stefania , Grieco Paolo , Merlino Francesco , Panarese Iacopo , Marino Federica Zito , Sangineto Moris , Romano Marco , Federico Alessandro 
Published: February 2023

AbstractBackgroundUrotensin‐II receptor‐ (UTR) related pathway exerts a key‐role in promoting inflammation. The aim was to assess the relationship between UTR expression and clinical, endoscopic and biochemical severity of ulcerative colitis (UC), exploring its predictivity of intravenous (iv) steroid administration therapeutic outcome.MethodsOne‐hundred patients with first diagnosis of UC and 44 healthy subjects were enrolled. UTR expression was assessed by qPCR, Western Blot (WB) and immunohistochemistry (IHC). Clinical, endoscopic and histological activity of UC were evaluated by using Truelove and Witts (T&W) severity index, Mayo Endoscopic Score (MES), and Truelove and Richards Index (TRI). The partial and full Mayo scores (PMS and FMS) were assessed to stage the disease.ResultsThe UTR expression, resulted higher in the lesioned mucosa of UC patients in comparison to healthy subjects (p < .0001 all). Direct relationship between UTR (mRNA and protein) expression and disease severity assessment (T&W, PMS, MES and TRI) was highlighted (p < .0001 all). UTR expression resulted also higher in the 72 patients requiring iv steroids administration compared to those who underwent alternative medications, (p < .0001). The 32 steroid‐non‐responders showed an increased UTR expression (WB, IHC and qPCR from lesioned mucosa), compared to 40 steroid‐responders (p: .0002, .0001, p < .0001 respectively). The predictive role of UTR expression (p < .05) on the negative iv steroids administration therapeutic outcome was highlighted and ROC curves identified the thresholds expressing the better predictive performance.ConclusionsUTR represents a promising inflammatory marker related to clinical, endoscopic, and histological disease activity as well as a predictive marker of steroid administration therapeutic outcome in the UC context.
Histological analysis for pulp mineralisation after severe intrusive luxation of immature molars in rats
Authors: Wang Nan , Gao Yike , Ren Huihui , He Linhai , Zhao Yuming 
Published: February 2023

AbstractBackground/AimPulp mineralisation is a survival process that may occur in the pulp of immature teeth following trauma. However, the mechanism of this process remains unclear. The aim of this study was to evaluate the histological manifestations of pulp mineralisation after intrusion in immature molars of rats.Materials and MethodsThree‐week‐old male Sprague–Dawley rats were subjected to intrusive luxation of the right maxillary second molar by an impact force from a striking instrument through a metal force transfer rod. The left maxillary second molar of each rat was used as a control. The control and injured maxillae were collected at 3, 7, 10, 14, and 30 days after trauma (n = 15 per time group) and evaluated using haematoxylin and eosin staining and immunohistochemistry. Independent two‐tailed Student's t‐test was used for statistical comparison of the immunoreactive area.ResultsPulp atrophy and mineralisation were observed in 30%–40% of the animals, and no pulp necrosis occurred. Ten days after trauma, pulp mineralisation, with osteoid tissue rather than reparative dentin, formed around the newly vascularised areas in the coronal pulp. CD90‐immunoreactive cells were observed in the sub‐odontoblastic multicellular layer in control molars, whereas the number of these cells was decreased in the traumatised teeth. CD105 localised in cells around the pulp osteoid tissue of the traumatised teeth, whereas in control teeth, it was only expressed in the vascular endothelial cells of capillaries in the odontoblastic or sub‐odontoblastic layers. In specimens with pulp atrophy at 3–10 days after trauma, hypoxia inducible factor expression and CD11b‐immunoreactive inflammatory cells increased.ConclusionsFollowing intrusive luxation of immature teeth without crown fractures in rats, no pulp necrosis occurred. Instead, pulp atrophy and osteogenesis around neovascularisation with activated CD105‐immunoreactive cells were observed in the coronal pulp microenvironment characterised by hypoxia and inflammation.