bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational modelling of separated flow
around a streamlined body at high incidence
Authors: Lien F.-S. , Leschziner M. A. 
Published: February 2023

AbstractA computational study has been undertaken of 3D vortical separation from the curved surface of a prolate spheroid at high angle of attack (10° and 30°). Attention focuses on the predictive capabilities of a new variant of non-linear, low Re eddy-viscosity model and full second-moment closure, the latter coupled to a low Re k-ε Boussinesq-viscosity model which is applied to the semi-viscous near-wall region. The study demonstrates that both anisotropy-resolving formulations return very similar predictive performance which is in several respects superior to that achieved with the k-ε model based on the linear stress-strain relations. At the higher incidence angle, transition is free, and this is the source of considerable uncertainty in respect of the sensitivity of the predicted leeward flow to the location of transition. While none of the models is fundamentally capable of capturing natural transition, the ability of the non-linear model to suppress turbulence generation by irrotational straining at the windward impingement region, thereby preventing (bypass) transition by diffusion of turbulence from the freestream to the laminar boundary layer, is exploited to demonstrate that the sensitivity of the separated leeward flow to the location of transition is weak.
In praise of skunkworks!
Authors: Platts M. J. 
Published: February 2023

AbstractWhat is of central importance in progressing new materials through from development to use is not technology but the creative efficiency of the team. What results is technology, both a competence and a confidence in handling the new material that makes the clarity of the demonstration of its potential a delight. It requires a holistic approach. Clear concepts require functionally direct embodiment, and equally expressive robust detailing. No amount of additional detail will retrieve a bad concept. Growing a team that has enough insight to tell the difference and the courage not to settle for less than the best is the challenge.
Heuristic design of composite laminates for strength, stiffness and multiple load cases
Authors: Morton S.K. , Webbert J.P.H. 
Published: February 2023

AbstractThe problem of designing a composite laminated plate subject to multiple loading cases is addressed using the methodology of heuristic redesign. Lower bounds on extensional stiffnesses together with a maximum strain first ply failure criterion constitute the design constraints. The general theory of heuristic redesign and its application to this particular problem are described. Results for different combinations of loading cases and redesign strategies are presented.
The Design of a Central Counterparty
Authors: Kuong John Chi-Fong , Maurin Vincent 
Published: February 2023

AbstractThis article analyzes the optimal allocation of losses via a Central Clearing Counterparty (CCP) in the presence of counterparty risk. A CCP can hedge this risk by mutualizing losses among its members. This protection, however, weakens members’ incentives to manage counterparty risk. Delegating members’ risk monitoring to the CCP alleviates this tension in large markets. To discipline the CCP at minimum cost, members offer the CCP a junior tranche and demand capital contribution. Our results endogenize key layers of the default waterfall and deliver novel predictions on its composition, collateral requirements, and CCP ownership structure.
How can the copepod Mesocyclops longisetus (Thiébaud, 1912) be used to control mosquito production effectively in pots, plates, and slabs?
Authors: Lima-Keppe Isabela , Saito Victor Satoru , Soares Jaqueline Fernanda , Nunes-Silva Aline , Ostrensky Antonio , Ferreira Iuri Emmanuel de Paula , Perbiche-Neves Gilmar 
Published: February 2023

Abstract
We tested the effectiveness of predation by the cyclopoid copepod Mesocyclops longisetus (Thiébaud, 1912) in Culicidae and Chironomidae larvae, aiming to test if (i) the introduction of copepods effectively controls mosquito larvae and (ii) the density of copepods is important for ensuring control. We conducted two semi-field experiments: the first involved 14 experimental runs over 75 consecutive days, compared in a randomized block design, four repetitions per treatment in each experimental run (block); and the second experiment involved a total of five experimental runs, lasting 25 and 33 days each. In the first experiment, culicid larvae were preyed on by copepods, especially at high copepod densities (15 copepods per litre), which reduced culicid densities by approximately 61% and 64% for different containers, considering that the environmental temperature declined linearly by about 10ºC from February (summer) to May (autumn) (32ºC to 22ºC). Even the lowest copepod density (5 per liter) produced a substantial reduction in the abundance of culicid larvae when chironomid larvae were abundant. On the other hand, there was no effective control of chironomid larvae. In the second experiment, increases in Culicidae and Chironomidae were concomitant with decreases in copepods. Thus, when the copepods were in high densities, there was no increase in insects, although the larvae of culicids were not eliminated from the experimental units. We conclude that the introduction of copepods in small containers and ponds can be useful for the control of culicid larvae without harming chironomid populations, and densities up to 15 per litre are recommended, although even low densities cause substantial reduction.
The role of gender in cognitive outcomes from stroke
Authors: Brandt Emma , Singh Sachinkumar , Bowren Mark , Bhagvathi Amol , Tranel Daniel , Boes Aaron D. 
Published: February 2023

AbstractObjective:Stroke can cause cognitive impairment, which can lead to challenges returning to day-to-day activities. Knowing what factors are associated with cognitive impairment post-stroke can be useful for predicting outcomes and guiding rehabilitation. One such factor is gender: previous studies are inconclusive as to whether gender influences cognitive outcomes post-stroke. Accounting for key variables, we examined whether there are gender differences in cognitive outcomes after stroke.Method:We analyzed data from neuropsychological assessments of 237 individuals tested in the chronic epoch (≥ 3 months) following ischemic stroke. Using ANCOVA and linear mixed modeling, we examined gender as a predictor of cognition as measured by general cognitive ability (g), Full-Scale IQ, and 18 cognitive tests, controlling for age at stroke onset, education, premorbid intelligence, and lesion volume.Results:There were no significant gender differences in overall cognitive outcomes as measured by g (p = .887) or Full-Scale IQ (p = .801). There were some significant gender differences on specific cognitive tests, with women outperforming men on scores from the Rey Auditory Verbal Learning Test (ps < .01) and men outperforming women on the Wechsler Adult Intelligence Scale Arithmetic and Information subtests (ps < .01).Conclusions:Our findings indicate that men and women have similar overall cognitive outcomes after stroke, when demographic and lesion factors are accounted for. Although men and women differed in their performance on some individual cognitive tests, neither gender performed systematically better or worse. However, for learning, working memory, and verbal knowledge/comprehension, gender may be an important predictor of outcome post-stroke.
Prominent role of executive functioning on the Phonemic Fluency Test in people with multiple sclerosis
Authors: Pitteri Marco , Vannucci Manila , Dapor Caterina , Guandalini Maddalena , Daffinà Angelica , Marastoni Damiano , Calabrese Massimiliano 
Published: February 2023

AbstractObjective:Executive functioning (EF) can be one of the earliest, despite under-detected, impaired cognitive domains in patients with multiple sclerosis (pwMS). However, it is still not clear the role of EF on verbal fluency tests given the presence of information processing speed (IPS) deficits in pwMS.Method:Performance of a group of 43 pwMS without IPS impairment as measured with the Symbol Digit Modalities Test (SDMT) and a group of 32 healthy controls (HC) was compared on the Phonemic and Semantic Fluency Tests. For each group, we scored the number of words generated (i) in the early time interval (i.e., first 15 sec, semi-automatic process) and (ii) in the late time interval (i.e., from 15 to 60 sec, controlled process).Results:Globally, pwMS produced significantly fewer words than HC on the Phonemic but not on the Semantic Fluency Test. Crucially, in the Phonemic Fluency Test pwMS generated significantly fewer words than HC in the late time interval, whereas no significant difference between the two groups emerged in the early time interval.Conclusions:These findings suggest that executive dysfunction is the core element on the Phonemic Fluency Test also in pwMS and it deserves attention in both research and clinical practice.
Predictors of high-grade radiation pneumonitis following radiochemotherapy for locally advanced non-small cell lung cancer: analysis of clinical, radiographic and radiotherapy-related factors
Authors: Weiss Elisabeth , Ricco Anthony , Mukhopadhyay Nitai , Rezai Gharai Leila , Deng Xiaoyan , Jan Nuzhat , Guy Christopher 
Published: February 2023

Abstract

Purpose:
In this study, the relation between radiation pneumonitis (RP) and a wide spectrum of clinical, radiographic and treatment-related factors was investigated. As scoring of low-grade RP can be subjective, RP grade ≥3 (RP ≥ G3) was chosen as a more objective and clinically significant endpoint for this study.

Methods and Materials:
105 consecutive patients with locally advanced non-small cell lung cancer underwent conventionally fractionated radio-(chemo-)therapy to a median dose of 64 Gy. A retrospective analysis of 25 clinical (gender, race, pulmonary function, diabetes, statin use, smoking history), radiographic (emphysema, interstitial lung disease) and radiotherapy dose- and technique-related factors was performed to identify predictors of RP ≥ G3. Following testing of all variables for statistical association with RP using univariate analysis (UVA), a forward selection algorithm was implemented for building a multivariate predictive model (MVA) with limited sample size.

Results:
Median follow-up of surviving patients was 33 months (9–132 months). RP ≥ G3 was diagnosed in 10/105 (9·5%) patients. Median survival was 28·5 months. On UVA, predictors for RP ≥ G3 were diabetes, lower lobe location, planning target volume, volumetric modulated arc therapy (VMAT), lung V5 Gy (%), lung Vspared5 Gy (mL), lung V20 Gy (%) and heart V5 Gy (% and mL). On MVA, VMAT was the only significant predictor for RP ≥ G3 (p = 0·042). Lung V5 Gy and lung V20 Gy were borderline significant for RP ≥ G3. Patients with RP ≥ 3 had a median survival of 10 months compared to 29·5 months with RP < G3 (p = 0·02).

Conclusions:
In this study, VMAT was the only factor that was significantly correlated with RP ≥ G3. Avoiding RP ≥ G3 is important as a toxicity per se and as a risk factor for poor survival. To reduce RP, caution needs to be taken to reduce low-dose lung volumes in addition to other well-established dose constraints.
Effective Porosity Profile at IODP Site C0002 in the Heart of the Nankai Accretionary Prism, and Its Use for Predicting In Situ Seismic Velocities
Authors: Doan Mai‐Linh , Dutilleul Jade , Henry Pierre 
Published: February 2023

AbstractUsing logging data and samples collected by the four expeditions of the International Ocean Discovery Program NanTroSEIZE drilling campaign that occupied Site C0002 in the Nankai margin located southwest of Japan, we determined effective porosity and sonic velocity profiles down to 3 km below the seafloor in the accretionary prism, above the seismogenic plate interface. We measured cation exchange capacity to differentiate clay‐bound water content from effective porosity, which is representative of compaction. The decrease in effective porosity with depth is fitted with a single exponential decay, which suggests hydrostatic conditions for most of the borehole. The Erickson‐Jarrard template was adapted to account for the actual clay‐bearing nature of the sediments. We used this improved P‐wave velocity–effective porosity relationship to fill shipboard data gaps and predict P‐ and S‐wave velocity profiles at Site C0002.
Electrostatic Ion Cyclotron Waves Observed by CSES in the Equatorial Plasma Bubble
Authors: Gou Xiaochen , Li Lei , Zhou Bin , Zhang Yiteng , Xie Lianghai , Cheng Bingjun , Feng Yongyong , Wang Jindong , Miao Yuanqing , Zhima Zeren , Shen Xuhui 
Published: February 2023

AbstractBroadband ELF electrostatic emissions have been observed by the China Seismo‐Electromagnetic Satellite (CSES) inside the equatorial plasma bubbles (EPBs). Analyses reveal that the electric field fluctuates nearly perpendicular to the ambient magnetic field, with the transverse component gyrotropically distributed around the magnetic field line. The observed emissions, Doppler shifted and broadened, are found to be close to the local oxygen ion (O+) cyclotron frequency in the plasma reference frame. Accompanying ion heating and deceleration are consistent with the consequences of the ion cyclotron resonance. All these results indicate that the electrostatic emissions pervading a major part of the EPB are the O+ electrostatic ion cyclotron (EIC) waves. The inhomogeneous‐energy‐density‐driven instability triggered by the non‐uniform electric field and density gradient across the EPBs could be the source of the EIC waves. The CSES observation provides new evidence for the shear driven EIC wave in the equatorial ionosphere.
Structure and Dynamics in Liquid Iron at High Pressure and Temperature. A First Principles Study
Authors: González Luis E. , González David J. 
Published: February 2023

AbstractWe have studied the evolution of structural and dynamic properties of liquid Fe as a function of pressure for 11 thermodynamic states close to the melting line. The pressure range considered goes from ambient pressure to 323 GPa, and the study has been carried out by using the ab‐initio molecular dynamics technique. The agreement between the calculated static structure and the available experimental data is very good, including details like an asymmetric second peak, which remains over most of the whole pressure range and suggests a significant local icosahedral short‐range order in the liquid. The dynamical structure is studied through the characteristics of the propagating density fluctuations and the associated longitudinal and transverse particle currents. The transverse dispersion relations expose two branches of modes for all pressures, whose range of appearance is analyzed and put in connection with the double‐peak structure of the Fourier spectra of velocity autocorrelation functions. We have also investigated the existence of fingerprints of transverse acoustic excitation modes in the dynamic structure factor for the high pressure states similar to those observed in the inelastic X‐ray scattering intensity data of liquid Fe at ambient pressure. The calculated electronic density of states shows that with increasing pressure there is a widening of the conduction band along with a decreasing significance of spin polarization. Finally, we also report results for transport coefficients like self‐diffusion, shear viscosity and adiabatic sound velocity, which are compared with the available experimental data.
Enhanced C2H2 Absorption Within Jupiter's Southern Auroral Oval From Juno UVS Observations
Authors: Giles Rohini S. , Hue Vincent , Greathouse Thomas K. , Gladstone G. Randall , Kammer Joshua A. , Versteeg Maarten H. , Bonfond Bertrand , Grodent Denis C. , Gérard Jean‐Claude , Sinclair James A. , Bolton Scott J. , Levin Steven M. 
Published: February 2023

AbstractReflected sunlight observations from the Ultraviolet Spectrograph (UVS) on the Juno spacecraft were used to study the distribution of acetylene (C2H2) at Jupiter's south pole. We find that the shape of the C2H2 absorption feature varies significantly across the polar region, and this can be used to infer spatial variability in the C2H2 abundance. There is a localized region of enhanced C2H2 absorption which coincides with the location of Jupiter's southern polar aurora; the C2H2 abundance poleward of the auroral oval is a factor of 3 higher than adjacent quiescent, non‐auroral longitudes. This builds on previous infrared studies, which found enhanced C2H2 abundances within the northern auroral oval. This suggests that Jupiter's upper‐atmosphere chemistry is being strongly influenced by the influx of charged auroral particles and demonstrates the necessity of developing ion‐neutral photochemical models of Jupiter's polar regions.
T cells in idiopathic pulmonary fibrosis: crucial but controversial
Authors: Deng Lishan , Huang Teng , Zhang Lei 
Published: February 2023

AbstractIdiopathic pulmonary fibrosis (IPF) has been extensively studied in recent decades due to its rising incidence and high mortality. Despite an abundance of research, the mechanisms, immune-associated mechanisms, of IPF are poorly understood. While defining immunopathogenic mechanisms as the primary pathogenesis is controversial, recent studies have verified the contribution of the immune system to the fibrotic progression of IPF. Extensive evidence has shown the potential role of T cells in fibrotic progression. In this review, we emphasize the features of T cells in IPF and highlight the controversial roles of different subtypes of T cells or even two distinct effects of one type of T-cell in diverse settings, and multiple chemokines and cell products are discussed. Furthermore, we discuss the potential development of treatments targeting the immune molecules of T cells and the feasibility of immune therapies for IPF in clinical practice.
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling
Authors: Hu Yuntao , Jiang Hongwei , Xu Yueyue , Chen Ganyi , Fan Rui , Zhou Yifei , Liu Yafeng , Yao Yiwei , Liu Renjie , Chen Wen , Zhang Ke , Chen Xin , Wang Rui , Qiu Zhibing 
Published: February 2023

AbstractMyocardial fibrosis, oxidative stress, and autophagy both play key roles in the progression of adverse cardiac remodeling. Stomatin-like protein 2 (SLP-2) is closely related to mitochondrial function, but little is known about its role and mechanism in cardiac remodeling. We developed doxorubicin (Dox), angiotensin (Ang) II, and myocardial ischemia-reperfusion (I/R) injury induced cardiac remodeling model and Dox treated H9C2 cell injury model using SLP-2 knockout (SLP-2-/-) mice and H9C2 cells with low SLP-2 expression. We first examined cardiac functional and structural changes as well as levels of oxidative stress, apoptosis and autophagy. We found that SLP-2 deficiency leads to decreased cardiac function and promotes myocardial fibrosis. After Dox and Ang II treatment, SLP-2 deficiency further aggravated myocardial fibrosis, increased myocardial oxidative stress and apoptosis, and activated autophagy by inhibiting PI3K-Akt-mTOR signaling pathway, ultimately exacerbating adverse cardiac remodeling. Similarly, SLP-2 deficiency further exacerbates adverse cardiac remodeling after myocardial I/R injury. Moreover, we extracted cardiomyocyte mitochondria for proteomic analysis, suggesting that SLP-2 deficiency may be involved in myocardial I/R injury induced adverse cardiac remodeling by influencing ubiquitination of intramitochondrial proteins. In addition, the oxidative stress, apoptosis and autophagy levels of H9C2 cells with low SLP-2 expression were further enhanced, and the PI3K-Akt-mTOR signaling pathway was further inhibited under Dox stimulation. Our results suggest that SLP-2 deficiency promotes myocardial fibrosis, disrupts normal mitochondrial function, overactivates autophagy via PI3K-Akt-mTOR signaling pathway, affects the level of ubiquitination, leads to irreversible myocardial damage, and ultimately exacerbates adverse cardiac remodeling.
An unexpected synthesis of azepinone derivatives through a metal-free photochemical cascade reaction
Authors: Song Lina , Tian Xianhai , Farshadfar Kaveh , Shiri Farshad , Rominger Frank , Ariafard Alireza , Hashmi A. Stephen K. 
Published: February 2023

AbstractAzepinone derivatives are privileged in organic synthesis and pharmaceuticals. Synthetic approaches to these frameworks are limited to complex substrates, strong bases, high power UV light or noble metal catalysis. We herein report a mild synthesis of azepinone derivatives by a photochemical generation of 2-aryloxyaryl nitrene, [2 + 1] annulation, ring expansion/water addition cascade reaction without using any metal catalyst. Among the different nitrene precursors tested, 2-aryloxyaryl azides performed best under blue light irradiation and Brønsted acid catalysis. The reaction scope is broad and the obtained products underwent divergent transformations to afford other related compounds. A computational study suggests a pathway involving a step-wise aziridine formation, followed by a ring-expansion to the seven-membered heterocycle. Finally, water is added in a regio-selective manner, this is accelerated by the added TsOH.
APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection
Authors: Manjunath Lavanya , Oh Sunwoo , Ortega Pedro , Bouin Alexis , Bournique Elodie , Sanchez Ambrocio , Martensen Pia Møller , Auerbach Ashley A. , Becker Jordan T. , Seldin Marcus , Harris Reuben S. , Semler Bert L. , Buisson Rémi 
Published: February 2023

AbstractDouble-stranded RNA produced during viral replication and transcription activates both protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression and replication through host shutoff of translation. In this study, we find that APOBEC3B forms a complex with PABPC1 to stimulate PKR and counterbalances the PKR-suppressing activity of ADAR1 in response to infection by many types of viruses. This leads to translational blockage and the formation of stress granules. Furthermore, we show that APOBEC3B localizes to stress granules through the interaction with PABPC1. APOBEC3B facilitates the formation of protein-RNA condensates with stress granule assembly factor (G3BP1) by protecting mRNA associated with stress granules from RNAse L-induced RNA cleavage during viral infection. These results not only reveal that APOBEC3B is a key regulator of different steps of the innate immune response throughout viral infection but also highlight an alternative mechanism by which APOBEC3B can impact virus replication without editing viral genomes.