bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole Blood–based Transcriptional Risk Score for Nonobese Type 2 Diabetes Predicts Dynamic Changes in Glucose Metabolism
Authors: Hou Yanan , Dai Huajie , Chen Na , Zhao Zhiyun , Wang Qi , Hou Tianzhichao , Zheng Jie , Wang Tiange , Li Mian , Lin Hong , Wang Shuangyuan , Zheng Ruizhi , Lu Jieli , Xu Yu , Chen Yuhong , Liu Ruixin , Ning Guang , Wang Weiqing , Bi Yufang , Wang Jiqiu , Xu Min 
Published: August 2023

Abstract

Context
The performance of peripheral blood transcriptional markers in evaluating risk of type 2 diabetes (T2D) with normal body mass index (BMI) is unknown.

Objective
We developed a whole blood–based transcriptional risk score (wb-TRS) for nonobese T2D and assessed its contributions on disease risk and dynamic changes in glucose metabolism.

Methods
Using a community-based cohort with blood transcriptome data, we developed the wb-TRS in 1105 participants aged ≥40 years who maintained a normal BMI for up to 10 years, and we validated the wb-TRS in an external dataset. Potential biological significance was explored.

Results
The wb-TRS included 144 gene transcripts. Compared to the lowest tertile, wb-TRS in tertile 3 was associated with 8.91-fold (95% CI, 3.53-22.5) higher risk and each 1-unit increment was associated with 2.63-fold (95% CI, 1.87-3.68) higher risk of nonobese T2D. Furthermore, baseline wb-TRS significantly associated with dynamic changes in average, daytime, nighttime, and 24-hour glucose, HbA1c values, and area under the curve of glucose measured by continuous glucose monitoring over 6 months of intervention. The wb-TRS improved the prediction performance for nonobese T2D, combined with fasting glucose, triglycerides, and demographic and anthropometric parameters. Multi-contrast gene set enrichment (Mitch) analysis implicated oxidative phosphorylation, mTORC1 signaling, and cholesterol metabolism involved in nonobese T2D pathogenesis.

Conclusion
A whole blood–based nonobese T2D-associated transcriptional risk score was validated to predict dynamic changes in glucose metabolism. These findings suggested several biological pathways involved in the pathogenesis of nonobese T2D.
Laparoscopic Anatomical Liver Resection of Segment VIII by Using ICG Fluorescence Positive Staining Under the Guidance of Laparoscopic Ultrasonography
Authors: Sun Ji , Lu Zhi-Yu , Zhai Jian-Xin , Lang Meng-Ran , Wang Hong-Guang 
Published: August 2023

Abstract
Background
Anatomical segmentectomy is a surgical procedure that completely removes a territory (or territories) of the third-order portal venous branches of a Couinaud segment (Wakabayashi et al. in J Hepatobil Pancreat Sci 29(1):82–98, 2022. https://doi.org/10.1002/jhbp.899). Laparoscopic segmentectomy of S8 is considered technically challenging because of the Precise dissection of the Glissonean pedicle of S8, and exposure of the middle and right hepatic veins are required (Ome et al. in J Am Coll Surg 230(3):e13–e20, 2020; Wakabayashi et al. in Ann Surg 261(4):619–29, 2015. https://doi.org/10.1097/sla.0000000000001184; Monden et al. in J Hepatobil Pancreat Sci 29(1):66–81, 2022. https://doi.org/10.1002/jhbp.898). This report describes a new approach, which can reduce unwanted damage to normal tissues and complications.

Methods
A 53-year-old man who has suffered from hepatitis B for 10 years was admitted for the treatment of two nodular tumors located in segment VIII. The surgical procedure began with the percutaneous injection of 5 mL, 0.025 mg/mL of ICG into the S8 portal branch by using an 18G PTCD needle under the guidance of laparoscopic ultrasound (Xu et al. in Surg Endosc 34(10):4683–4691, 2020. https://doi.org/10.1007/s00464-020-07691-5; Wang et al. in Ann Surg 274(1):97–106, 2021. https://doi.org/10.1097/sla.0000000000004718; Aoki et al. in J Am Coll Surg 230(3):e7–e12, 2020. https://doi.org/10.1016/j.jamcollsurg.2019.11.004), followed by liver transection on the cranial side of the liver, which used the ICG fluorescence images for exposing the roots of the middle and right hepatic veins and dissecting and ligating S8 portal pedicle. The excision specimen was sent for histopathological diagnosis.

Results
It took 200 min for the operation and 60 min for the total Pringle maneuver. The estimate of blood loss was 110 mL. The final histopathologic results of the two nodules were hepatocellular carcinoma (HCC). The patient was discharged on postoperative Day 6 with no complications.

Conclusions
Laparoscopic anatomical liver resection of S8 has been demonstrated to be feasible. Under the guidance of laparoscopic ultrasonography, ICG positive staining was proven to be optimal for Anatomical segmentectomy.
Effective Mn Doping of Co3O4 to Improve the Catalytic Performance of Co3O4/N-doped Carbon toward Hydrogenation Reduction Reaction of p-Nitrophenol
Authors: Fu Xiaojian , Huang Boxing , Li Kuilin , Shen Yanchao , Li Pingyun 
Published: August 2023

Abstract
This work reports that 5% Mn doping of Co3O4 can greatly improve catalytic performance of Co3O4/N-doped carbon (Co3O4/NC) catalysts toward hydrogenation reaction of p-nitrophenol by using NaBH4 as reducing agent. Mn doping can cause formation of cobalt or oxygen vacancies without changing the crystalline structure of Co3O4. The 5%Mn-doped Co3O4/NC has a high activity parameter of 173 s−1·g−1 when the molar ratio of NaBH4:p-nitrophenol is 100:1, while the un-doped Co3O4/NC catalyst has a low parameter of 37.0 s−1·g−1.
The impact of the SARS-CoV-2 infection on the risk of developing preeclampsia
Authors: Kozłowska Anna , Korzeniowska Anna , Gendek Karolina , Gąbka Ilona , Dalmata Weronika , Dąbrowski Jan , Zygmunt-Siembida Ewelina , Chojęta Dariusz 
Published: August 2023

Introduction and purpose:

The COVID-19 pandemic has significantly affected the health, life and quality of life of many people around the world. It caused huge changes in the daily functioning of entire societies. Pregnant women are a unique group of people who are particularly at risk. They are accompanied by fear for their health, but also fear of the impact of the disease on their offspring. The pandemic has also caused new challenges for mothers-to-be that have not occurred so far. In this paper, we would like to present the current state of knowledge on the impact of SARS-CoV-2 infection on the risk of developing pre-eclampsia.

State of knowledge:

We analyzed studies showing the impact of COVID-19 infection on the health of pregnant women, especially on the risk of developing pre-eclampsia. Data from many studies are contradictory. Some studies do not indicate a significant impact of coronavirus infection on the development of pre-eclampsia. Some of them confirm a higher incidence of pre-eclampsia in pregnant women with confirmed COVID-19 infection.

Conclusions:

Despite the experience gained, there are still many unknowns. Thanks to research, we have more and more knowledge about the course of COVID-19 in pregnant women and its impact on their lives. Many observations are still needed to formulate clear conclusions about the impact of COVID-19 on the risk of developing pre-eclampsia. It is also necessary to continue to educate women, encourage compliance with the recommendations of doctors and the World Health Organization to prevent the spread of coronavirus.
Online Stochastic Max-Weight Bipartite Matching: Beyond Prophet Inequalities
Authors: Papadimitriou Christos , Pollner Tristan , Saberi Amin , Wajc David 
Published: August 2023

The rich literature on online Bayesian selection problems has long focused on so-called prophet inequalities, which compare the gain of an online algorithm to that of a “prophet” who knows the future. An equally natural, though significantly less well-studied, benchmark is the optimum online algorithm, which may be omnipotent (i.e., computationally unbounded), but not omniscient. What is the computational complexity of the optimum online? How well can a polynomial-time algorithm approximate it? Motivated by applications in ride hailing, we study the above questions for the online stochastic maximum-weight matching problem under vertex arrivals. For this problem, a number of [Formula: see text]-competitive algorithms are known. This is the best possible ratio for this problem, as it generalizes the original single-item prophet inequality problem. We present a polynomial-time algorithm, which approximates the optimal online algorithm within a factor of 0.51—strictly more than the best-possible constant against a prophet. In contrast, we show that it is PSPACE-hard to approximate this problem within some universal constant [Formula: see text]. Funding: Financial support from the National Science Foundation [Grants CCF1763970, CCF1812919, and CCF191070], the Office of Naval Research [Grant N000141912550], and Cisco Research is gratefully acknowledged.
FAKES NEWS NAS AULAS DE LÍNGUA PORTUGUESA NO PIBID LETRAS: LEITURA E AÇÕES (AUTO)FORMATIVAS
Authors: Silva Ana Lucia Gomes da , Neta Mirena Umbuzeiro Guimarães 
Published: August 2023

Este texto é resultado da experiência gestada colaborativamente no Pibid Letras na Universidade do Estado da Bahia nas aulas de Língua Portuguesa com ênfase nas ações (auto)formativas da leitura a fim de contribuir para uma formação leitora crítica que toma como centralidade temas atuais do cotidiano dos/das estudantes de educação básica, a inserção de atividades e ações (auto)formativas. O objetivo central é apresentar a experiência realizada no combate às fake news, numa ação de co-docência implicada, cuja rede colaborativa, toma a experiência e a leitura como formação. De natureza qualitativa o estudo assume a pesquisa bibliográfica e documental como procedimentos metodológicos e como dispositivo de produção de dados e analítico a inspiração cartográfica. Adotou-se, como corpus de análise o conjunto de produções imagéticas, da experiência do Pibid Letras. Os resultados apontam evidências de aprendizagens, e pistas de coautoria e cocriação, propiciadas aos estudantes e docentes, em virtude da ambiência favorável e desafiadora, tais como: imersão em ambiências híbridas, aprendizagens diferenciadas em que fomos instados a exercitar e experimentar juntos na educação on line diante da concepção de aula em co docência. Apontaram ainda os (re)planejamentos e inflexões realizadas no processo, sobretudo para suscitar a leitura crítica das fake news, considerando a escuta sensível dos distintos pontos de vista dos sujeitos envolvidos, o debate democrático, atentando para os princípios epistemológicos e organizativos da metodologia de trabalho adotada no Pibid, produzindo nas aulas a (auto) formação fronteiriça universidade e educação básica.
MANIFESTO CIBORGUE: CIÊNCIA, TECNOLOGIA E FEMINISMO-SOCIALISTA NO FINAL DO SÉCULO XX
Authors: Simões Ana Beatriz 
Published: August 2023

Esta resenha dedica-se a apresentar o texto “Manifesto ciborgue: ciência, tecnologia e feminismo-socialista no final do século XX, de Donna Haraway. Discute-se o ensejo da autora em propor um mito ciborgue, profícuo a um ideário feminista emancipador, pautado na luta contra uma linguagem universal, que, ilusoriamente, seria capaz de codificar fidedignamente a realidade. Além disso, destaca-se a visão da autora acerca da escrita como uma tecnologia ciborgue, em uma luta pela linguagem contra a univocidade da comunicação e de um código que traduza a realidade de modo perfeito. Por meio destes pressupostos, Donna Haraway propõe uma escrita ciborgue de autoria feminina, que se distancia dos mitos fálicos e ocidentais sobre a origem e lança-se a subvertê-los.
EDUCAÇÃO E TECNOLOGIAS DIGITAIS EM REDE
Authors: Carvalho Felipe , Pimentel Mariano , Santos Edméa dos , Menezes Marcos Marcos Vinícius Dias de , Maddalena Tania Lucía 
Published: August 2023

V. 7, n. 1 (2023) - Publicação contínua – Jan./Dez. PROCESSOS FORMATIVOS E SUBJETIVOS EM TEMPO DE CIBERCULTURA
MOVIMENTOS (AUTO) BIOGRÁFICOS (COM) TEXTOS NARRATIVOS
Authors: Duarte de Souza Adria Simone 
Published: August 2023

O artigo apresenta as abordagens narrativas em educação e discute os processos que sustentam o ato de narrar a si mesmo, articulando constantemente esse ato a produção de efeitos de identidades/identificações. Reflete ainda sobre os diferentes níveis que constroem as dimensões da subjetividade, apresentando a aposta do sujeito (auto)biográfico defendida por Passeggi e Souza (2017) e Passeggi (2020). A partir dessas abordagens, analisa o livro “Canumã: a travessia” de Ytanajé Coelho Cardoso por meio da noção de acontecimento proposta por Barros (2016) e sujeito autobiográfico Passeggi (2020), pontuando que na medida em que o narrador relata suas memórias no tempo da narração, rememora o passado adormecido e materializa as lembranças desse passado no texto.
"MARINA, VAMOS VIAJAR?" JOGO EDUCATIVO INTERDISCIPLINAR PARA O ENSINO FUNDAMENTAL
Authors: Rosa Anderson Aparecido , Oliveira João Ricardo , Santos Vanessa Matos dos , Lopes Renato De Aquino 
Published: August 2023

O presente artigo foi elaborado através das oportunidades geradas pelo avanço e inovação da tecnologia acerca de sua utilização em sala de aula no formato da gamificação e dos jogos educativos. Nesse sentido, foi identificada a necessidade de propor o desenvolvimento de um jogo interdisciplinar nas disciplinas de História e Geografia no Ensino Fundamental para crianças de 6 a 10 a anos de idade. A proposta se deu no desenvolvimento de um jogo educativo intitulado “Marina, vamos viajar?”, que oferece por meio de desafios lúdicos estímulos à busca de informações e conhecimentos a respeito de diversos aspectos da construção do território brasileiro, da sua população e sua história. A proposta se justifica pela flexibilidade e mobilidade de sua utilização, uma vez que o jogo poderá ser utilizado tanto em sala de aula, quanto em casa, com o aluno estando próximo dos pais, amigos e outros familiares, facilitando o processo de aprendizagem de forma lúdica e ampliada. Considera-se que ao utilizar o jogo como parte da didática no processo de ensino, este se torna um facilitador na consolidação dos conteúdos estudados de forma divertida, criativa, e possibilita que alunos se sintam agentes ativos da sua própria aprendizagem
Convergence Exercises for Convergence Insufficiency Type Exotropia in Bilateral Internuclear Ophthalmoplegia
Authors: Kuwera Edward , Hariharakumar Shreya 
Published: August 2023

Purpose; To report a case of successfully treated convergence insufficiency type exotropia (CI-XT) in the context of bilateral internuclear ophthalmoplegia (BINO) using only convergence exercises.
Observations; A 17-year-old male with a history of a resected posterior fossa pilocytic astrocytoma presented with constant diplopia since the craniotomy. Patient and his parents were adamant in pursuing surgical treatment for his new onset strabismus. With appropriate counseling and management with convergence exercises only, the CI-IXT was successfully treated without surgery over the course of two years.
Conclusion and Importance; We present a non-invasive approach to the treatment of CI-IXT in the context of a BINO, also known as wall-eyed BINO (WEBINO). This approach should be considered before any surgical intervention, especially if prism is unable to successfully neutralize diplopia for any extended period of time.
Super low-frequency electric field measurement based on Rydberg atoms
Authors: Li Ling , Jiao Yuechun , Hu Jinlian , Li Huaqiang , Shi Meng , Zhao Jianming , Jia Suotang 
Published: August 2023

We demonstrate the measurement of super low-frequency electric field using Rydberg atoms in an atomic vapor cell with inside parallel electrodes, thus overcoming the low-frequency electric-field-screening effect at frequencies below a few kHz. Rydberg electromagnetically induced transparency (EIT) spectra involving 52D5/2 state is employed to measure the signal electric field. An auxiliary DC field is applied to improve the sensitivity. A DC Stark map is demonstrated, where the utilized 52D5/2 exhibits m
j
= 1/2, 3/2, 5/2 Stark shifts and splittings. The m
j
= 1/2 state is employed to detect the signal field because of its larger polarizability than that of m
j
= 3/2, 5/2. Also, we show that the strength of the spectrum is dependent on the angle between the laser polarizations and the electric field. With optimization of the applied DC field to shift the m
j
= 1/2 Rydberg energy level to a high sensitivity region and the laser polarizations to obtain the maximum m
j
= 1/2 signal, we achieve the detection of the signal electric field with a frequency of 100 Hz down to 214.8 µV/cm with a sensitivity of 67.9 µV cm−1Hz−1/2, and the linear dynamic range is over 37 dB. Our work extends the measurement frequency of Rydberg sensors to super low frequency with high sensitivity, which has the advantages of high sensitivity and miniaturization for receiving super low frequency.
How socioeconomically disadvantaged people access, understand, appraise, and apply health information: A qualitative study exploring health literacy skills
Authors: Stormacq Coraline , Oulevey Bachmann Annie , Van den Broucke Stephan , Bodenmann Patrick 
Published: August 2023

Objectives
Health literacy, or a person’s competence to access, understand, appraise and apply health information, can be considered a mediating factor between socioeconomic characteristics and health disparities. Socioeconomically disadvantaged people in particular present with less health literacy skills. To develop targeted interventions tailored to their real needs, it is important to understand how they function and what difficulties they encounter when dealing with health information. The purpose of this study was to explore their experiences when accessing, understanding, appraising, and applying health information in their everyday lives.

Methods
Semi-structured face-to-face interviews were conducted with 12 socioeconomically disadvantaged adults living in the community in Switzerland (age range: 44–60 years old).

Results
Thematic analysis of the interviews yielded four themes, describing the health literacy processes of participants, related barriers, and compensatory strategies used: Financial insecurity triggers the need for health information; Pathway 1: Physicians as ideal (but expensive) interlocutors; Pathway 2: The internet as a suboptimal alternative; and Pathway 3: Relatives as a default resource. The progression of socioeconomically disadvantaged people in the health literacy process is like an ‘obstacle course’, with numerous steps taken backwards before they can develop compensatory strategies to overcome the barriers to obtaining health information.

Conclusions
Financial deprivation seems to be the most important factor contributing to health literacy barriers. Appraising health information is the health literacy skill with which socioeconomically disadvantaged people struggle the most. Physician-based, individual skills-based, organizational, and policy-based interventions are needed to help them overcome their health literacy challenges.
Predicting climate-change induced heat-related illness risk in Grand Canyon National Park visitors
Authors: Buttke Danielle E. , Raynor Brinkley , Schuurman Gregor W. 
Published: August 2023

Background
The climate crisis is the greatest public health threat of the 21st century. Excessive heat is responsible for more deaths than any other extreme weather event, and the frequency, intensity, and duration of extreme heat events are increasing globally due to climate change. Exposure to excessive heat can result in heat related illnesses (HRIs) and long-term poor health outcomes. Physical exertion, sudden exposure to excessive heat, and the lack of physical or behavioral adaptation resources are all associated with greater HRI risk, which is expected to increase for visitors to Grand Canyon National Park (GCNP) and other public lands as climate change worsens.

Objectives
Our objectives were to understand 1) the relationship between weather and HRI in GCNP visitors, 2) how future HRI rates may change, and 3) how land management agencies can update risk mitigation strategies to match changing risk and better manage an increased HRI burden.

Methods
We utilized previously published data on HRI in GCNP visitors, and records of daily visitation, temperatures, and maximum and minimum daily humidity from the same study period to develop a model estimate for HRI risk. We then used future climate projections from the World Climate Research Programme’s Coupled Model Intercomparison Project phase 5 multi-model dataset to model future HRI risk under different climate scenarios.

Results
The incidence of HRI was significantly associated with maximum daily temperature and minimum relative humidity, and was more common in the shoulder season months. We estimated that HRI will increase 29%-137% over 2004–2009 levels through 2100, assuming no change in visitation.

Discussion
Climate change will continue to increase HRI risk for GCNP visitors and poses risks to public land managers’ mission to provide for safe recreation experiences for the benefit of this and future generations in places like GCNP. Excessive risk during the shoulder season months presents an opportunity to increase preventative search and rescue and education efforts to mitigate increased risk.
Real-life safety of Emtricitabine/Tenofovir Alafenamide/Bictegravir
Authors: Squillace Nicola , Ricci Elena , Maggi Paolo , Taramasso Lucia , Menzaghi Barbara , De Socio Giuseppe Vittorio , Piconi Stefania , Maurizio Celesia Benedetto , Orofino Giancarlo , Sarchi Eleonora , Pellicanò Giovanni Francesco , Simeone Filomena , Valsecchi Laura , Bandera Alessandra , Cenderello Giovanni , Attala Letizia , Angioni Goffredo , Falasca Katia , Cascio Antonio , Bargiacchi Olivia , Di Biagio Antonio , Bonfanti Paolo ,   for the CISAI Study Group
Published: August 2023

Introduction
Integrase strand transfer inhibitors (INSTI) are one of the most prescribed drug classes for the treatment of HIV infection worldwide. Emtricitabine/Tenofovir Alafenamide/ Bictegravir (FTC/TAF/BIC) has been evaluated in randomized clinical trials; few studies have verified tolerability and safety in clinical practice. Our aim was to investigate the metabolic and hepatic safety in a real-life setting of FTC/TAF/BIC.

Materials and methods
Consecutive people living with HIV infection (PLWH) enrolled in the SCOLTA project, switching to or initiating their first antiretroviral treatment with FTC/TAF/BIC were included. PLWH with HBV co-infection were excluded. Metabolic and hepatic variables were collected at T0 and T1, were defined as baseline and 6-month follow-up respectively, and their modifications were analysed using the paired t-test and the analysis of variance.

Results
Five hundred and thirty-nine PLWH with at least one follow-up visit were included in the analysis. Mean age was 48 years (±12.1), 74% were male, 16.1% were naïve to antiretrovirals (ART). At T1, ART-experienced PLWH showed a significant reduction of total cholesterol (TC) and triglycerides, and a slight increase in blood glucose (BG) and ALT. On the contrary, in ART-naïve PLWH blood lipids significantly increased, although with an unaffected TC/high density lipoprotein (HDL)-c ratio, while alanine aminotransferase (ALT) decreased significantly, mainly in those with altered baseline level. The treatment interruptions were 45 (8.4%) over the whole observation period, 13 (2.4%) due to AEs. The most frequent AEs were related to the central nervous system (6 events of depression, insomnia, headache, agitation) and 3 PLWH discontinued the regimen because of grade 1–2 weight gain.

Conclusions
In ART-experienced PLWH switching to FTC/TAF/BIC a significant improvement of lipid profile occurred but with significant BG and ALT variation without clinical relevance. In ART-naïve PLWH, blood lipids increased even though lipid profile did not worsen, and a trend towards normalization of liver enzymes was suggested. FTC/TAF/BIC is well tolerated in the real life setting.