bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atherosclerosis Imaging Quantitative Computed Tomography (AI‐QCT) to guide referral to invasive coronary angiography in the randomized controlled CONSERVE trial
Authors: Kim Yumin , Choi Andrew D. , Telluri Anha , Lipkin Isabella , Bradley Andrew J. , Sidahmed Alfateh , Jonas Rebecca , Andreini Daniele , Bathina Ravi , Baggiano Andrea , Cerci Rodrigo , Choi Eui‐Young , Choi Jung‐Hyun , Choi So‐Yeon , Chung Namsik , Cole Jason , Doh Joon‐Hyung , Ha Sang‐Jin , Her Ae‐Young , Kepka Cezary , Kim Jang‐Young , Kim Jin Won , Kim Sang‐Wook , Kim Woong , Pontone Gianluca , Villines Todd C. , Cho Iksung , Danad Ibrahim , Heo Ran , Lee Sang‐Eun , Lee Ji Hyun , Park Hyung‐Bok , Sung Ji‐min , Crabtree Tami , Earls James P. , Min James K. , Chang Hyuk‐Jae 
Published: February 2023

AbstractAimsWe compared diagnostic performance, costs, and association with major adverse cardiovascular events (MACE) of clinical coronary computed tomography angiography (CCTA) interpretation versus semiautomated approach that use artificial intelligence and machine learning for atherosclerosis imaging‐quantitative computed tomography (AI‐QCT) for patients being referred for nonemergent invasive coronary angiography (ICA).MethodsCCTA data from individuals enrolled into the randomized controlled Computed Tomographic Angiography for Selective Cardiac Catheterization trial for an American College of Cardiology (ACC)/American Heart Association (AHA) guideline indication for ICA were analyzed. Site interpretation of CCTAs were compared to those analyzed by a cloud‐based software (Cleerly, Inc.) that performs AI‐QCT for stenosis determination, coronary vascular measurements and quantification and characterization of atherosclerotic plaque. CCTA interpretation and AI‐QCT guided findings were related to MACE at 1‐year follow‐up.ResultsSeven hundred forty‐seven stable patients (60 ± 12.2 years, 49% women) were included. Using AI‐QCT, 9% of patients had no CAD compared with 34% for clinical CCTA interpretation. Application of AI‐QCT to identify obstructive coronary stenosis at the ≥50% and ≥70% threshold would have reduced ICA by 87% and 95%, respectively. Clinical outcomes for patients without AI‐QCT‐identified obstructive stenosis was excellent; for 78% of patients with maximum stenosis < 50%, no cardiovascular death or acute myocardial infarction occurred. When applying an AI‐QCT referral management approach to avoid ICA in patients with <50% or <70% stenosis, overall costs were reduced by 26% and 34%, respectively.ConclusionsIn stable patients referred for ACC/AHA guideline‐indicated nonemergent ICA, application of artificial intelligence and machine learning for AI‐QCT can significantly reduce ICA rates and costs with no change in 1‐year MACE.
Emerging therapeutic strategies for enhancing sensitivity and countering resistance to programmed cell death protein 1 or programmed death‐ligand 1 inhibitors in non–small cell lung cancer
Authors: Villaruz Liza C. , Blumenschein George R. , Otterson Gregory A. , Leal Ticiana A. 
Published: February 2023

AbstractThe availability of agents targeting the programmed cell death protein 1 (PD‐1)/programmed death‐ligand 1 (PD‐L1) immune checkpoint has transformed treatment of advanced and/or metastatic non–small cell lung cancer (NSCLC). However, a substantial proportion of patients treated with these agents do not respond or experience only a brief period of clinical benefit. Even among those whose disease responds, many subsequently experience disease progression. Consequently, novel approaches are needed that enhance antitumor immunity and counter resistance to PD‐(L)1 inhibitors, thereby improving and/or prolonging responses and patient outcomes, in both PD‐(L)1 inhibitor‐sensitive and inhibitor‐resistant NSCLC. Mechanisms contributing to sensitivity and/or resistance to PD‐(L)1 inhibitors in NSCLC include upregulation of other immune checkpoints and/or the presence of an immunosuppressive tumor microenvironment, which represent potential targets for new therapies. This review explores novel therapeutic regimens under investigation for enhancing responses to PD‐(L)1 inhibitors and countering resistance, and summarizes the latest clinical evidence in NSCLC.
Secure personal authentication in fog devices via multimodal rank‐level fusion
Authors: Saravanakumar Selvaraj , Saravanan Thangavel 
Published: February 2023

SummaryIn recent years, Fog and edge computing have gained enormous increases and usage of Internet of Things (IoT) devices in research and development even though it provides challenges such as security and privacy. One way to ensure this is a fusion of multimodal biometrics authentication systems, which offer highly reliable biometric authentication solutions to reduce the failure to enroll rate, increase the degree of freedom, and deter spoof attacks. Since unimodal biometric systems often face significant limitations due to sensitivity to noise, data quality, non‐universality, and illumination variations. In this research, we propose management of access control to ensure the desired level of security, a Rank level fusion integration method. ORL, GT, CASIA, and VGG‐face databases were used for testing and evaluating the implemented system. Thus, using the LDA with SCE based feature selection approach, the average GAR percent for the facial, hearing, and palm vein is 3.25% for the facial and muffs pulse and 8.55% for the head and palm vein result was the overall performance of the biometric system even in the presence of low‐quality data in the Fog environment.
Analyzing the employee/employer relationships in the corporate social responsibility context: An empirical investigation of SMEs
Authors: Bastian Fanny , Poussing Nicolas 
Published: February 2023

AbstractWith the adoption of corporate social responsibility (CSR), firms are invited to identify, consult and take into account the expectations of their stakeholders. In this context, firms are expected to promote direct relationships with their employees while employee participation traditionally took the form of indirect institutional participation via trade unions or employee representatives. By mobilizing stakeholder theory, this study aims to analyze the impact of adopting a CSR approach on the existence of direct relationships between employees and employers. Three relationships are analyzed: information, consultation, and dialog. Using survey data, the empirical analysis shows that SMEs which have adopted a CSR approach in the social field are more likely to inform and consult their employees; but the adoption of CSR is not linked to dialog with them. This research is closely linked to the sustainable development goals 8.8 and 16.7 and gives new argument to promote CSR in SMEs. In particular, our findings underline the importance of CSR as a driver of employer–employee relationships because the CSR‐oriented companies seem more open to stakeholder dialogs with employees. This argument is relevant to companies that are seeking to implement, CSR, innovative human resources practices and industrial relations policies to improve working conditions and to create a win–win situation. © 2023 John Wiley & Sons, Ltd.
Integrating environmental DNA monitoring to inform eel (Anguilla anguilla) status in freshwaters at their easternmost range—A case study in Cyprus
Authors: Griffiths Nathan P. , Wright Rosalind M. , Hänfling Bernd , Bolland Jonathan D. , Drakou Katerina , Sellers Graham S. , Zogaris Stamatis , Tziortzis Iakovos , Dörflinger Gerald , Vasquez Marlen I. 
Published: February 2023

AbstractDespite significant population declines and targeted European Union regulations aimed at Anguilla anguilla conservation, little attention has been given to their status at their easternmost range. This study applies wide‐scale integrated monitoring to uncover the present‐day eel distribution in Cyprus' inland freshwaters. These are subject to increasing pressures from water supply requirements and dam construction, as seen throughout the Mediterranean. We applied environmental DNA metabarcoding of water samples to determine A. anguilla distribution in key freshwater catchments. In addition, we present this alongside 10 years of electrofishing/netting data. Refuge traps were also deployed to establish the timing of glass eel recruitment. These outputs are used together, alongside knowledge of the overall fish community and barriers to connectivity, to provide eel conservation and policy insights. This study confirm the presence of A. anguilla in Cyprus' inland freshwaters, with recruitment occurring in March. Eel distribution is restricted to lower elevation areas, and is negatively associated with distance from coast and barriers to connectivity. Many barriers to connectivity are identified, though eels were detected in two reservoirs upstream of dams. The overall fish community varies between freshwater habitat types. Eels are much more widespread in Cyprus than previously thought, yet mostly restricted to lowland intermittent systems. These findings make a case to reconsider the requirement for eel management plans. Environmental DNA‐based data collected in 2020 indicate that “present‐day” eel distribution is representative of 10‐year survey trends. Suggesting that inland freshwaters may act as an unrealized refuge at A. anguilla's easternmost range. Conservation efforts in Mediterranean freshwaters should focus on improving connectivity, therefore enabling eels to access inland perennial refugia. Thus, mitigating the impact of climate change and the growing number of fragmented artificially intermittent river systems.
Mind the housing inclusion gap: The voice of people with disabilities in German housing politics
Authors: Slavici Melanie 
Published: February 2023

AbstractAccessible housing is essential for disabled and elderly people with physical restraints to live independently. In reality, however, there is a considerable lack of accessible housing in Germany. While investigating the reasons for this insufficient supply, this article discusses the underlying policy mix and scrutinizes German accessible housing politics. Based on 50 semi‐structured interviews in the two states Saxony‐Anhalt and Hesse, it identifies the weak political influence of disability lobbyists as the primary reason. Lacking structural, organizational, and institutional power, they do not get access to decision‐makers in housing politics but are labeled as social policy actors. On the other hand, housing and building industries have considerable resources to push their housing policy agenda. Nevertheless, the empirical findings clearly show the challenging endeavor of integrating social and building policies in accessible housing while contributing to the overarching understanding of politics in minor policy fields.
Risk‐targeted seismic design for collapse safety of SMA‐based structures considering temperature effect
Authors: Chen Junbai , Wang Wei , Fang Cheng 
Published: February 2023

AbstractA risk‐targeted seismic design method for shape memory alloy (SMA)‐based structures is proposed in this study, taking account of temperature effect and the uncertainty of regional temperature distribution. To facilitate discussion of the overall performance of SMA‐based structures, the thermo‐mechanical behaviors of both SMA material and SMA‐based self‐centering braces (SMA‐SCB) are first introduced, where an advanced simulation method is developed. Aided by an extensive parametric study, the collapse capacity of SMA‐based structural systems is comprehensively investigated, where the predominant factors controlling the seismic performance are revealed. Based on the results, the concepts of collapse capacity‐temperature function and temperature‐modified collapse capacity are introduced in this study. The temperature‐modified collapse capacity combines the information of regional temperature distribution and temperature‐dependent behavior of the SMA‐based structures. The temperature‐modified collapse capacity is developed to determine the risk‐targeted design spectral acceleration for satisfying the specific risk‐targeted performance objective. The procedure of the proposed design method is then demonstrated by examining a three‐story SMA‐based self‐centering braced frame (SMA‐SCBF) building in a selected seismic‐active region, followed by a probabilistic method to evaluate the collapse risk. The results manifest that by using the proposed design method, the SMA‐based structures can successfully achieve acceptable performance during the design service life, and the influence of temperature should be carefully taken into consideration in both assessment and design phases.
Precipitation-driven gamma radiation enhancement over the Atlantic Ocean
Authors: Barbosa Susana M , Dias Nuno , Almeida Carlos , Silva Guilherme Amaral , Ferreira António , Camilo António , Silva Eduardo 
Published: February 2023

Gamma radiation over the Atlantic Ocean Gamma radiation over the
Atlantic Ocean was measured continuously from January to May 2020 by a
NaI(Tl) detector installed on board the Portuguese navy’s ship NRP
Sagres. Enhancements in the gamma radiation values are identified
automatically by an algorithm for detection of anomalies in mean and
variance as well as by visual inspection. The anomalies are typically
+50% above the background level and relatively rare events
(~ < 10% of the days). All the detected
anomalies are associated with simultaneous precipitation events,
consistent with the wet deposition of scavenged radionuclides. The
enhancements are detected in the open ocean even at large distances (+
500 km) from the nearest coastline. Back trajectories reveal that half
of these events are associated with air masses experiencing continental
land influences, but the other half don’t display evidence of recent
land contact. The enhancements in gamma radiation very far from land and
with no evidence of continental fetch from back trajectories are
difficult to explain as resulting only from radionuclides with a
terrestrial source such as radon and its progeny. Further investigation
and additional measurements are needed to improve understanding on the
sources of ambient radioactivity in the open ocean and assess whether
gamma radiation in the marine environment is influenced not only by
radionuclides of terrestrial origin, but also cosmogenic radionuclides,
like Beryllium-7, formed in the upper atmosphere but with the ability to
be transported downward and serve as a tracer of the aerosols to which
it attaches.
Mobilising international resource management certification schemes: Re‐configuration of the global shark fin supply network by producers
Authors: Omoto Reiko 
Published: February 2023

AbstractAs one approach to publicising sustainability efforts at the local level for a wider audience, international resource management certification schemes and their eco‐label programmes have been widely used as a verification tool. The case of Japanese shark fishery based in Kesennuma, Miyagi shows the full picture of the current global context behind a highly controversial commodity: shark fins. Campaigns against shark finning directed by environmental NGOs have led to shark fin being taken off the menu at some Chinese high‐class hotels. The shark fishery in Kesennuma is currently working toward obtaining Marine Stewardship Council (MSC) certification to prove that their shark products are not the result of finning, with the expectation that the certification will provide a clear distinction between human moral issues and sustainable resource management issues. Drawing on this case, this paper analyses the network of cooperative stakeholders in order to re‐configure a global sustainable commodity network for shark fins. It has been almost a quarter century since MSC was officially launched as an independent organisation in 1997. Initially, MSC certification was a major strength of differentiation, allowing producers of certified seafood to sell at a higher price, but the acquisition of certification by multiple fisheries targeting the same or similar species has reduced the economic benefits for individual fisheries. By analysing the shark fishery, which require resource management on the high seas, this paper provides new insights into how MSC certification can be mobilised by producers.
Efficacy and safety of hydroxyzine for sleep in adults: Systematic review
Authors: Burgazli Courtney R. , Rana Krishna B. , Brown Jamie N. , Tillman Frank 
Published: February 2023

AbstractObjectiveThe purpose of this systematic review is to assess the efficacy and safety of hydroxyzine for insomnia in adults.MethodsA comprehensive literature search of PubMed, Embase, and CENTRAL databases was conducted to identify relevant published studies through October 2022 using the search terms: hydroxyzine and sleep, insomnia, sleep disorder or sleep initiation and maintenance disorders. Studies identified for review included prospective, interventional designs or cohort trials that reported impact of hydroxyzine on sleep in adults. Animal studies, case reports, non‐English articles, letters to the editor, case studies, and conference abstracts were excluded. Data were extracted using a standardized systematic process.ResultsFive articles were identified for inclusion, including 1 open‐label and 4 randomized controlled trials, evaluating a total of 207 patients receiving hydroxyzine 25 mg, 50 mg, or 100 mg at bedtime. Mixed efficacy was demonstrated in the sleep measures of sleep onset, sleep maintenance, and sleep quality. The most common adverse drug effect was dry mouth, although 4 of the 5 studies did not report safety outcomes.ConclusionsThe studies in this review suggest hydroxyzine could be considered as a short‐term treatment option for adults with insomnia for whom previous therapy was ineffective, not tolerated, or contraindicated. Additional long‐term studies with an active comparator are needed to further establish its role in insomnia treatment.
AMP‐activated protein kinase‐farnesoid X receptor pathway contributes to oleanolic acid‐induced liver injury
Authors: Huang Jianxiang , Liao Songjie , Fu Xiaolong , Wang Yi , Zhou Shaoyu , Lu Yuanfu 
Published: February 2023

AbstractNatural pentacyclic triterpenoid oleanolic acid (OA) is used as an over‐the‐counter drug for acute and chronic hepatitis. However, clinical use of OA‐containing herbal medicines has been reported to cause cholestasis, and the specific mechanism is unknown. The purpose of this study was to explore how OA causes cholestatic liver injury via the AMP‐activated protein kinase (AMPK)‐farnesoid X receptor (FXR) pathway. In animal experiments, it was found that OA treatment activated AMPK and decreased FXR and bile acid efflux transport proteins expression. When intervened with the specific inhibitor Compound C (CC), it was observed that AMPK activation was inhibited, the reduction of FXR and bile acid efflux transport protein expression was effectively alleviated, serum biochemical indicators were significantly reduced, and liver pathological damage brought about by OA was effectively ameliorated. In addition, OA was found to downregulate the expression of FXR and bile acid efflux transport proteins by activating the ERK1/2‐LKB1‐AMPK pathway in cellular experiments. The ERK1/2 inhibitor U0126 was used to pretreat primary hepatocytes, and this drastically reduced the phosphorylation levels of LKB1 and AMPK. The inhibition effects of OA on FXR and bile acid efflux transport proteins were also effectively alleviated after pretreatment with CC. In addition, OA‐induced downregulation of FXR gene and protein expression levels was significantly prevented after silencing AMPKα1 expression in AML12 cells. Our study demonstrated that OA inhibited FXR and bile acid efflux transporters through the activation of AMPK, thus leading to cholestatic liver injury.
Benchmarking applicability of medium‐resolution cryo‐EM protein structures for structure‐based drug design
Authors: Lee Seho , Seok Chaok , Park Hahnbeom 
Published: February 2023

AbstractCryo‐electron microscopy (cryo‐EM) is gaining large attention for high‐resolution protein structure determination in solutions. However, a very high percentage of cryo‐EM structures correspond to resolutions of 3–5 Å, making the structures difficult to be used in in silico drug design. In this study, we analyze how useful cryo‐EM protein structures are for in silico drug design by evaluating ligand docking accuracy. From realistic cross‐docking scenarios using medium resolution (3–5 Å) cryo‐EM structures and a popular docking tool Autodock‐Vina, only 20% of docking succeeded, when the success rate doubles in the same kind of cross‐docking but using high‐resolution (<2 Å) crystal structures instead. We decipher the reason for failures by decomposing the contribution from resolution‐dependent and independent factors. The heterogeneity in the protein side‐chain and backbone conformations is identified as the major resolution‐dependent factor causing docking difficulty from our analysis, while intrinsic receptor flexibility mainly comprises the resolution‐independent factor. We demonstrate the flexibility implementation in current ligand docking tools is able to rescue only a portion of failures (10%), and the limited performance was majorly due to potential structural errors than conformational changes. Our work suggests the strong necessity of more robust method developments on ligand docking and EM modeling techniques in order to fully utilize cryo‐EM structures for in silico drug design.
Diagnostic challenges of renal medullary carcinoma and the role for cytologic assessment: Case report and literature review
Authors: Severseike Benjamin O. , Schafernak Kristian T. , Willard Scott D. , Goncalves Luis F. , Kothari Alok K. , Eshun Francis K. , Mangum Ross 
Published: February 2023

AbstractBackgroundRenal medullary carcinoma (RMC) is a diagnostically challenging, aggressive primary renal malignancy associated with abysmal survival. Delays in diagnosis contribute to most patients having diffusely metastatic disease at the time of initial presentation.MethodsWe present the case of a 13‐year‐old African American male with sickle cell trait who presented with a renal mass and hematuria. Evaluation included imaging, fluid cultures, and cytologic assessment.ResultsPatient was diagnosed with RMC based on cytologic assessment of sub‐centimeter fluid collections aspirated from the left kidney at the time of cortical biopsy for suspected renal mass. The additional fluid aspiration in conjunction with renal biopsy was an atypical but crucial step in early diagnosis.ConclusionCytomorphologic evaluation of fluid biospecimens is not currently part of the standard work‐up for patients with renal masses but, when available, can provide crucial information that reduces time to diagnosis. Prompt symptom recognition and treatment initiation may improve patient outcomes.