bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Post-operative Stimulated Serum Thyroglobulin: Role in Preventing Unnecessary Radioactive Iodine Treatment in Low to Intermediate Risk Papillary Thyroid Cancer
Authors: Sezer Havva , Yazıcı Dilek , Terzioğlu Tarık , Tezelman Serdar , Canbaz Hande Bulut , Yerlikaya Aslıhan , Demirkol Mehmet Onur , Kapran Yersu , Çolakoğlu Bülent , Çilingiroğlu Eda Nur , Alagöl Faruk 
Published: June 2023

Aim The aims of the study are to evaluate the predictive value of early post-operative stimulated thyroglobulin (sTg) analysis on the recurrence risk, and to define a cut-off value that is related to recurrence risk in low to intermediate risk papillary thyroid cancer (PTC). Methods This retrospective cohort study included individuals who were diagnosed with PTC aged 18 years or older and had been operated by experienced surgeons of a tertiary university hospital between the years 2011 and 2021. The American Thyroid Association thyroid cancer guidelines version 2015 was used as the risk stratification system. Early sTg measurement obtained at 3-4 weeks after surgery when TSH >30 µIU/mL. Data was collected from the hospital database. A total of 328 patients who had post-operative early sTg values with negative anti-Tg antibodies were included. Results The median age was 44 years. Of the 328 patients, 223 (68%) were women. The median tumor diameter was 11 mm. One hundred ninety-one patients (58.2%) had low risk and 137 (41.8%) had intermediate risk for recurrent disease. Of the 328 patients, 4.0% had recurrent disease. In multivariate Cox regression, post-operative early sTg value [OR: 1.070 (1.038-1.116), P = .000], and the pre-operative malign cytology [OR: 1.483 (1.080-2.245), P = .042] were independent risk factors for recurrence. On the ROC curve analysis, the cut-off value of early sTg was 4.1 ng/mL for those with recurrent disease. Conclusion This study demonstrated that early sTg could predict recurrent disease in patients with low to intermediate risk PTC. A cut-off of 4.1 ng/mL was identified with a high negative predictive value.
The Effect of Surgery on the Prognosis of Gastric Lymphoma: A Meta-analysis
Authors: Shi Min , Yao Yao , Ding Haifeng , Yang Jian , Zhang Cong , Wu Ying , Guo Tao 
Published: June 2023

ObjectiveSurgery is an effective clinical approach that has been used for the treatment of gastric lymphoma. However, its specific effect on the prognosis of patients with gastric lymphoma remains largely unknown. The current meta-analysis aimed to identify the effect of surgery on the prognosis of gastric lymphoma.MethodsWe searched the MEDLINE, Embase, and Cochrane Central databases to obtain relevant studies investigating the influence of surgery on overall survival (OS) and relapse-free survival (RFS). We extracted the hazard ratios (HRs) and associated 95% confidence intervals (CIs) of each included report for pooled analysis. We assessed heterogeneity (I2statistic) and funnel plots to select the data models and evaluate publication bias.ResultsUltimately, we included 12 studies containing 26 comparisons in the current quantitative meta-analysis. The analysis revealed that surgery had no significant effect on OS (HR .83, P = .13) or RFS (HR .78, P = .08). However, subgroup analysis revealed that the effect of surgery on OS differed significantly between the surgery plus conservative therapy subgroup and the conservative therapy alone groups, with HR = .69 ( P = .01). No significant publication bias was detected regarding the main outcomes.ConclusionSurgery had a limited effect on the prognosis of patients with gastric lymphoma. However, the use of surgery as an additional therapy may confer potential benefits. This was an interesting research direction, and additional high-quality, large-scale randomized controlled trials should be conducted.
“Apagando el sistema”: Fusion Music as Protest Soundscape in Lima, Peru
Authors: Vik Alissa 
Published: June 2023

The song “Apagando el sistema” was released in 2015 during protests against the youth labor law known as the Ley Pulpín and frequently reposted on Facebook to show solidarity with various political and social issues. Analyzed from the perspective of what I call “fusion aesthetics,” it can be considered to build on the tradition of the Latin American Nueva Canción, reflect the fragmented nature of protests, and help the musicians negotiate their identities as mestizos and fight racism and discrimination in Peru. La canción "Apagando el sistema" fue lanzada en 2015 durante las protestas de la ley laboral juvenil conocida como Ley Pulpín, y se republicó en Facebook con frecuencia para mostrar solidaridad con diversos temas políticos y sociales. Un análisis desde una perspectiva de lo que yo llamo "estética de fusión” nos permite decir que la canción se basa en la tradición de la Nueva Canción latinoamericana, refleja la naturaleza fragmentada de las protestas y ayuda a los músicos a negociar sus identidades como mestizos y luchar contra el racismo y la discriminación en el Perú.
Multi-Lens Noticing in Preservice Teachers’ First Attempts at Facilitating Discussion in Diverse English Classes
Authors: Banes Leslie C. , Houk Julia G. , Athanases Steven Z. , Sanchez Sergio L. 
Published: June 2023

Background: Classroom discourse featuring meaning making supports students achieving discipline-specific learning. However, moving beyond recitation requires developing beliefs, skills, structures, and practices. Any theorizing we do about developing discussion practice must attend to realities of culturally and linguistically diverse classrooms. Purpose: Our study offers a teacher education innovation that prepares ELA candidates to facilitate discussion, framed by a set of noticing lenses: noticing for collaborative communication, content learning, and equity. We asked: As they reflected on their first attempts at facilitating discussion in diverse secondary ELA classes, what did preservice teachers (PSTs) notice about their discussion practices and students’ engagement and response patterns? Participants: Our study features an inquiry course in a teacher credential program. Participants were 83 PSTs pursuing secondary English credentials, student teaching in diverse classrooms. Three-fifths identified as White, with 39% identifying as PSTs of color. Design: We constructed a database of multipage essays in which PSTs reflected on videotaped discussion tryouts. We developed a coding scheme from research literature and emerging themes from data review to capture what PSTs noticed. We organized themes conceptually using and adapting a multi-lens noticing framework. Additionally, we constructed vignettes to explore ways two PSTs were noticing discussion engagements among their diverse learners. Results: We found evidence of all three noticing lenses in the data. Of the three lenses, collaborative communication was densest. PSTs were preoccupied with “getting students talking.” PSTs also reflected on attempts at co-constructing meaning and tracking flow of ideas. Three-fourths documented noticing of cross-content literacy development. Fewer PSTs demonstrated attending to collaborative interpretation of literary works, an important aspect of ELA-specific discussion. Although PSTs were beginning to leverage cultural and linguistic knowledge, many were not yet responding to or educating about racism and other forms of bias. To demonstrate multi-lens noticing in practice, we present two vignettes of how PSTs interpreted salient moments in classroom discussion. Conclusions: Our research provides a launching for understanding what PSTs notice in early stages of leading discussion and highlights what is needed to jump-start this process early. Findings underscore the need to build authentic and tangible discussion-leading practice, with deeper attention to ELA disciplinary goals and equity. Our study highlights a framework as an analytical and pedagogical tool to help PSTs organize and reflect on emerging discussion practices. Framework and findings may serve as a heuristic for teacher educators committed to fostering learning about equitable discussion.
Effectiveness of an individualised occupational therapy intervention programme (ABLE) using adaptational strategies on activities of daily living among persons with chronic conditions: A randomised controlled trial (RCT)
Authors: Hagelskjær Vita , Bülow Cecilie von , Nielsen Kristina Tomra , Henriksen Marius , Wæhrens Eva Ejlersen 
Published: June 2023

Objective Compare the effectiveness of a problem-solving, individualised, home-based occupational therapy intervention (ABLE 2.0), to usual occupational therapy, on activities of daily living (ADL) ability in persons with chronic conditions. Design A single-centre, double-blinded, randomised controlled trial with 10- and 26-week follow-up. Setting A Danish municipality. Subjects Persons with chronic conditions experiencing problems performing ADL tasks ( n = 80). Interventions ABLE 2.0 was compared with usual occupational therapy. Main measures Coprimary outcomes were self-reported ADL ability (ADL-Interview Performance) and observed ADL motor ability (Assessment of Motor and Process Skills) at Week 10. Secondary outcomes were self-reported ADL ability (ADL-Interview Performance) and observed ADL motor ability (Assessment of Motor and Process Skills) at Week 26, and perceived satisfaction with ADL ability (ADL-Interview Satisfaction) and observed ADL process ability (Assessment of Motor and Process Skills) at Weeks 10 and 26. Results In total, 78 persons were randomly assigned: 40 to usual occupational therapy and 38 to ABLE 2.0. No statistically significant nor clinically relevant difference between group mean changes in primary outcomes was identified from baseline to Week 10 (ADL-Interview Performance [−0.16; 95% CI: −0.38 to 0.06] and Assessment of Motor and Process Skills ADL motor ability [−0.1; 95% CI: −0.3 to 0.1]). At Week 26, a statistically significant and clinically relevant difference was found in Assessment of Motor and Process Skills ADL motor ability (LS mean change: −0.3; 95% CI: −0.5 to −0.1) between groups. Conclusion ABLE 2.0 was effective in improving observed ADL motor ability at 26 weeks.
The intentional pursuit of everyday life while dying: A longitudinal qualitative study of working-aged adults living with advanced cancer
Authors: Brose Julie M , Willis Eileen , Morgan Deidre D 
Published: June 2023

Background: People living with advanced cancer experience functional decline and increasing difficulty participating in activities of daily living over their final year of life, consequently reducing quality of life. Palliative rehabilitation may serve to mitigate some of these challenges by optimising function. However, limited research and theory explore the rehabilitative process of adaptation amid increasing dependency, often experienced by people living with advanced cancer. Aim: To explore the lived experience of everyday life for working-aged adults living with advanced cancer, and how this changes over time. Design: A longitudinal hermeneutic phenomenological approach was employed, using in-depth semi-structured interviews. Data was analysed using inductive thematic analysis, and findings mapped against the Model of Human Occupation and illness experience literature. Setting/participants: Purposively sampled working-aged adults (40–64 years) with advanced cancer were recruited by a rural home care team in Western Canada. Results: Thirty-three in-depth interviews were conducted over 19 months with eight adults living with advanced cancer. Advanced cancer and other losses have a disruptive impact on daily life. Despite experiencing progressive functional decline, these adults intentionally sought to participate in valued everyday activities. Adaptation to ongoing deterioration occurred through engagement in daily life. Conclusions: Despite experiencing disruption to routines and daily life, people living with advanced cancer seek to continue doing what is important to them, albeit in a modified form. Adaptation to functional decline is an active, ongoing process and occurs through continued engagement in activities. Palliative rehabilitation can facilitate participation in everyday life.
Comprehensive Approach for Improving Adherence to Prenatal Iron and Folic Acid Supplements Based on Intervention Studies in Bangladesh, Burkina Faso, Ethiopia, and India
Authors: Sanghvi Tina G. , Nguyen Phuong Hong , Forissier Thomas , Ghosh Sebanti , Zafimanjaka Maurice , Walissa Tamirat , Mahmud Zeba , Kim Sunny 
Published: June 2023

Background: The World Health Organization recommends daily iron and folic acid (IFA) supplementation during pregnancy, but consumption remains low, and high prevalence of anemia among pregnant women (PW) persists. Objectives: This study aims to (1) examine factors at the health system, community, and individual levels, which influence adherence to IFA supplements; and (2) describe a comprehensive approach for designing interventions to improve adherence based on lessons learned from 4 country experiences. Methods: We conducted literature search, formative research, and baseline surveys in Bangladesh, Burkina Faso, Ethiopia, and India and applied health systems strengthening and social and behavior change principles to design interventions. The interventions addressed underlying barriers at the individual, community, and health system levels. Interventions were further adapted for integration into existing large-scale antenatal care programs through continuous monitoring. Results: Key factors related to low adherence were lack of operational protocols to implement policies, supply chain bottlenecks, low capacity to counsel women, negative social norms, and individual cognitive barriers. We reinforced antenatal care services and linked them with community workers and families to address knowledge, beliefs, self-efficacy, and perceived social norms. Evaluations showed that adherence improved in all countries. Based on implementation lessons, we developed a program pathway and details of interventions for mobilizing health systems and community platforms for improving adherence. Conclusion: A proven process for designing interventions to address IFA supplement adherence will contribute to achieving global nutrition targets for anemia reduction in PW. This evidence-based comprehensive approach may be applied in other countries with high anemia prevalence and low IFA adherence.
A Story is Better Told With Collective Interests: An Experimental Examination of Misinformation Correction During the COVID-19 Pandemic
Authors: Xiao Xizhu , Borah Porismita , Lee Danielle Ka Lai , Su Yan , Kim Sojung 
Published: June 2023

Purpose To examine strategies that help motivate social correction behaviors to combat COVID-19-related health misinformation on social media. Design 2 (message types: narrative vs statistics) x 2 (social frames: individual vs collective) between-subjects experiment. Setting Qualtrics-based online experiment via Lucid. Subjects The final sample consisted of 450 participants ( M age = 45.31). Measures Manipulation check, discussion and correction intentions, and need for cognition (NFC). Analysis ANCOVA and PROCESS model 3 were used to analyze the data. Results Significant interaction effects emerged between message types and social frames on discussion intention, F (1, 442) = 5.26, P = .022, and correction intention, F (1, 442) = 4.85, P = .028. Collectively framed narrative correction ( Mdiscussion = 3.15, Mcorrection = 3.17) was more effective than individually framed narrative correction ( Mdiscussion = 2.73, Mcorrection = 2.77). Individually framed statistical correction ( Mdiscussion = 3.10, Mcorrection = 2.95) was more persuasive than collectively framed statistical correction ( Mdiscussion = 2.89, Mcorrection = 2.69). The interaction effects were more evident for people low on NFC, P = .031. Conclusion In motivating social correction behaviors, a story is better told with an emphasis on collective interests, and numbers are better presented with personal gains and losses. Future interventions should identify the target audience based on the level of NFC.
The possible cytotoxicity and genotoxicity assessment of indaziflam on HepG2 cells
Authors: Könen Adıgüzel Serpil 
Published: June 2023

The use of pesticides in farmland has increased considerably to protect crops against pests, weeds, and diseases. However, pesticides and/or their residues in ecosystems may affect non-target organisms. Indaziflam is a widely used herbicide in agricultural areas in the southern region of Turkey. Therefore, this study aimed to investigate the possible genotoxic and cytotoxic effects of indaziflam on HepG2 cells using comet assay, micronucleus assay, and xCELLigence. The HepG2 cells were treated with various concentrations of indaziflam for different duration of time based on xCELLigence results. Accordingly, the cells were incubated with indaziflam at final concentrations of 1, 5, 10, 20, 40, and 80 μg/mL for 96 h for cytotoxicity assay. To assess genotoxicity, cells were treated with indaziflam at final concentrations of 10, 40, and 100 μg/mL for 4 and 24 h. Ethanol was used as a solvent for indaziflam. Hydrogen peroxide (40 μM) was used as a positive control. Studies have revealed that indaziflam did not show a statistically cytotoxic effect at the tested doses. Nevertheless, genotoxicity studies showed that indaziflam induced both DNA strand breaks and micronucleus numbers depending on the exposure time and dose.
Predictors and consequences of moral distress in home-care nursing: A cross-sectional survey
Authors: Petersen Julia , Melzer Marlen 
Published: June 2023

Background Nurses frequently face situations in their daily practice that are ethically difficult to handle and can lead to moral distress. Objective This study aimed to explore the phenomenon of moral distress and describe its work-related predictors and individual consequences for home-care nurses in Germany. Research design A cross-sectional design was employed. The moral distress scale and the COPSOQ III-questionnaire were used within the framework of an online survey conducted among home-care nurses in Germany. Frequency analyses, multiple linear and logistic regressions, and Rasch analyses were performed. Participants and research context The invitation to participate was sent to every German home-care service ( n = 16,608). Ethical considerations The study was approved by the Data Protection Office and Ethics Committee of the German Federal Institute for Occupational Safety and Health. Results A total of 976 home-care nurses participated in this study. Job characteristics, such as high emotional demands, frequent work-life-conflicts, low influence at work, and low social support, were associated with higher disturbance caused by moral distress in home-care nurses. Organizational characteristics of home-care services, such as time margin with patients, predicted moral distress. High disturbance levels due to moral distress predicted higher burnout, worse state of health, and the intention to leave the job and the profession, but did not predict sickness absence. Conclusions To prevent home-care nurses from experiencing severe consequences of moral distress, adequate interventions should be developed. Home-care services ought to consider family friendly shifts, provide social support, such as opportunities for exchange within the team, and facilitate coping with emotional demands. Sufficient time for patient care must be scheduled and short-term takeover of unknown tours should be prevented. There is a need to develop and evaluate additional interventions aimed at reducing moral distress, specifically in the home-care nursing sector.
Network Pharmacology and Experimental Analyses on Astragalus membranaceus (Huangqi) Effects on Endotoxin-induced Uveitis Model in Rats
Authors: Lu Jing , Wu Yujie , Yang Yijing , Zhou Jing , Huang Bo , Xie Chengfeng , Peng Qinghua , Zhang Xiaohuan 
Published: June 2023

Objectives This study is aimed at identifying critical therapeutic targets of Astragalus membranaceus (Huangqi (HQ)) and investigating the effects and mechanisms of HQ treating uveitis. The potential drug targets of HQ and main active ingredients were obtained from the Traditional Chinese medicine (TCM) systems pharmacology database and analysis platform (TCMSP, http://tcmspnw.com ). Materials and Methods Cytoscape software was used to identify the disease targets of uveitis. Drug targets and disease targets were compared, and intersected hubs were applied for the active ingredient-target network and protein-protein-interaction (PPI) network construction. Signaling pathway enrichment annotation was performed to identify possible signaling involved in uveitis treatment. An endotoxin-induced uveitis (EIU) model was established, and the therapeutic effects of total flavonoids of Astragalus (TFA) on uveitis were investigated by examining the improvement of eye symptoms, histopathological alterations, and the levels of cytokines. Results Based on network pharmacological analysis, HQ could modulate the initiation and progression of uveitis by reducing the production of cytokines and regulating cell apoptosis via the NOD-like receptor (NLR), apoptosis, and toll-like receptor (TLR) signaling pathways. Based on animal experiments, high-dose TFA could reduce rat’s iris congestion, reduce anterior chamber exudation and pus, restore pupil size, and decrease the release of inflammatory factors IFN-γ and IL-10. Network pharmacological and experimental analyses revealed that TFA regulates the release of inflammatory factors through the NLR and TLR signaling pathways, thus regulating the immune system of EIU rats and ultimately relieving inflammation responses in uveitis rats.
Guidelines for implementing advanced thermal analysis methods in building design
Authors: Yamamoto Tatsuhiro , Taniguchi Kazuhiro 
Published: June 2023

Although the thermal environment of buildings with thermally complex building envelopes can be predicted, comprehensive guidelines are not available for designers to implement the thermal-environment analysis. Therefore, this study examines the application scope of advanced thermal-analysis methods from the designers’ perspective. The results of the simple model were consistent with the experimental values, with an error of approximately 0.5°C. The analytically determined convective heat-transfer-coefficient values were within 0.3–0.5°W・m2K, and the difference in the predicted values between the results of the simplified and detailed models was minor. The convective heat transfer coefficient calculated using the reference temperature defined at the dimensionless distance y+ was more accurate than that was obtained using the general energy simulation incorporating the boundary-layer theory. Although the simplified advection rate had a maximum error of approximately 150 m3/h, it was considered acceptable. The differences amongst the zones were less than 0.59°C, which is considered minor. The results obtained by using summer advection were sufficiently accurate. Furthermore, the dew-point temperature was used to evaluate the risk of dew condensation. Specifically, the results indicated that the introduction of outside air increased the risk of condensation on the floor.