bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Additives and Growth Inhibitors in Improving the Physicochemical Properties of Silicoaluminophosphate Molecular Sieve, SAPO‐11
Authors: Manal Arjun K. , Advani Jacky H. , Kanna Narasimharao , Kumar Pramod , Srivastava Rajendra 
Published: May 2023

AbstractSilicoalumiophosphates (SAPOs) are microporous crystalline materials extensively utilized as adsorbents and catalysts. The present work utilized two strategies to synthesize nanocrystalline SAPO‐11. The first strategy involves a surfactant as a mesoporogen to reduce the crystallite size and increase the surface area for the materials synthesized at 200 °C in 2 days. In the second strategy, the synthesis temperature and time were significantly reduced to 160 °C and 3 h using propylene oxide as a pH accelerator. The reduction in the particle size and the improvement in the surface area were achieved using propyltriethoxysilane, which inhibited the growth of SAPO‐11 particles. The materials were thoroughly characterized using XRD, N2‐sorption, FTIR, pyridine‐adsorbed FTIR, electron microscopy, XPS, and NMR. The surfactant‐assisted synthesis formed a nanorod morphology with a large external and BET surface area. The low‐temperature synthesis involving silane as a growth inhibitor and propylene oxide as a pH modulator demonstrated a rectangular nanoplatelet morphology with a large surface area. The synthesis was scaled up to 10 g with no change in the experimental parameters. A synthesis strategy facilitating nuclei formation and retarding the growth of particle size will attract academia and industrial researchers to utilize these strategies for the manufacturing of zeolites of different frameworks on a large scale.
Abnormal gray matter volume and functional connectivity patterns in social cognition‐related brain regions of young children with autism spectrum disorder
Authors: Bai Chen , Wang Yunlei , Zhang Yan , Wang Xianna , Chen Zhenbo , Yu Weiyong , Zhang Haojie , Li Xingzhu , Zhu Kaixuan , Wang Yuxiang , Zhang Tong 
Published: May 2023

AbstractAutism spectrum disorder (ASD) is associated with abnormal brain imaging findings, but descriptions thereof are inconsistent. The aim of the present study was to investigate brain abnormalities in young children with ASD using a combination of structural and functional brain magnetic resonance imaging (MRI). Structural and resting‐state functional MRI was performed in 67 children with ASD (aged 2–7 years) and 39 age‐matched typically developing (TD) controls. Voxel‐based morphometry was used to evaluate differences in brain structure between groups. Topologic parameters of the functional brain network were compared by graph theoretic analysis and network connectomes were compared with network‐based statistics. A support vector machine (SVM) was used to discriminate between ASD and TD groups. Results demonstrated young children with ASD had increased gray matter volumes (GMVs) in the right medial superior frontal gyrus and left fusiform gyrus compared with the TD group. The ASD group had altered subnetwork connectivity in frontal and temporal lobes and other social cognition‐related brain regions. Functional connectivity in the left superior temporal gyrus and left temporal pole of the middle temporal gyrus was positively correlated with adaptability and language developmental quotient (DQ) in children with ASD. The combination of the brain structural and functional features had 86.2% accuracy in discriminating between ASD and TD. The present study shows that young children with ASD have altered GMVs and functional networks in social cognition‐related brain regions, which are potential neuroimaging biomarkers for ASD.
Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors
Authors: Sanati Mehdi , Afshari Amir R. , Ahmadi Seyed Sajad , Moallem Seyed Adel , Sahebkar Amirhossein 
Published: May 2023

AbstractRegarding the multimechanistic nature of cancers, current chemo‐ or radiotherapies often fail to eradicate disease pathology, and frequent relapses or resistance to therapies occur. Brain malignancies, particularly glioblastomas, are difficult‐to‐treat cancers due to their highly malignant and multidimensional biology. Unfortunately, patients suffering from malignant tumors often experience poor prognoses and short survival periods. Thus far, significant efforts have been conducted to discover novel and more effective modalities. To that end, modulation of the ubiquitin‐proteasome system (UPS) has attracted tremendous interest since it affects the homeostasis of proteins critically engaged in various cell functions, for example, cell metabolism, survival, proliferation, and differentiation. With their safe and multimodal actions, phytochemicals are among the promising therapeutic tools capable of turning the operation of various UPS elements. The present review, along with an updated outline of the role of UPS dysregulation in multiple cancers, provided a detailed discussion on the impact of phytochemicals on the UPS function in malignancies, especially brain tumors.
Conflict in a word‐based approach‐avoidance task is stronger with positive words
Authors: Klackl Johannes , Blechert Jens , Jonas Eva 
Published: May 2023

AbstractBackgroundValence and motivational direction are linked. We approach good things and avoid bad things, and experience overriding these links as conflicting. Positive valence is more consistently linked with approach than negative valence is linked with avoidance. Therefore, avoiding positive stimuli should produce greater behavioral and neural signs of conflict than approaching negative stimuli.MethodsIn the present event‐related potential study, we tested this assumption by contrasting positive and negative conflict. We used the manikin task, in which we read positive and negative words that they needed to approach and avoid.ResultsConsistent with our prediction, positive conflict prolonged reaction times more than negative conflict did. A late (500–1000 ms following word onset) event‐related potential that we identified as the Conflict slow potential, was only sensitive to positive conflict.ConclusionThe results of this study support the notion that avoiding positive stimuli is more conflicting than approaching negative stimuli. The fact that the conflict slow potential is typically sensitive to response conflict rather than stimulus conflict suggests that the manikin task primarily requires people to override prepotent responses rather than to identify conflicting stimuli. Thus, the present findings also shed light on the psychological processes subserving conflict resolution in the manikin task.
Impact of sex and serum lipids interaction on working memory: A large‐scale brain networks study
Authors: Zhang Shujun , Li Xuezhen , Sun Zhanguo , Chen Yueqin , Yu Yongqiang 
Published: May 2023

AbstractBackgroundsPrevious studies have demonstrated that both serum lipid levels and sex are crucial factors associated with individual cognition. However, the impact of sex and serum lipid interaction effects on the brain and cognition remains largely unknown. This study aimed to explore the underlying neural mechanisms among sex, serum lipids, and cognition using large‐scale brain networks.MethodsResting‐state functional MRI data were collected from 157 young healthy adults. Independent component analysis was used to examine large‐scale inter‐ and intra‐network functional connectivity (FCs). Peripheral venous blood samples were collected to measure serum lipid levels. The three‐back task was employed to assess cognition (i.e., working memory). General linear model, correlation, and mediation analyses were conducted to examine the interaction effects of sex and serum lipids on large‐scale brain networks and their relationship with working memory.ResultsWe found that inter‐network connectivity with the executive control network at its core was more susceptible to sex and triglyceride interaction effects. The intra‐network connectivity in the dorsal attention networks (DANs), lateral visual networks, and anterior default mode networks was influenced by the interaction effects of sex and total cholesterol (TC)/low‐density lipoprotein cholesterol. Specifically, correlations between serum lipids and affected brain networks were found to be sex‐specific. In addition, higher intra‐network FC in the right inferior parietal (R‐IPL) of the DAN correlated with a longer three‐back reaction time in females. More importantly, the relationship between serum TC levels and three‐back reaction time was mediated by intra‐network connectivity in the R‐IPL of the DAN.ConclusionsOur findings describe the impact of sex and serum lipid interaction effects on large‐scale brain networks, as well as on cognitive function. Our data suggest that sex‐specific usage of serum lipids or brain networks would be beneficial for monitoring and therapy in dyslipidemia‐related cognition decline.
Variables related to health‐related quality of life among breast cancer survivors after participation in an interdisciplinary treatment combining mindfulness and physiotherapy
Authors: Martín Josune , García Susana , Anton‐Ladislao Ane , Ferreiro Josefa , Martín Maximina , Padierna Angel , Quintana José M. ,   the CAMISS‐prospective group
Published: May 2023

AbstractBackgroundBreast cancer diagnosis and treatment increase the potential psychological impact on breast cancer survivors (BCS). The objective of this study was to assess the effects of an interdisciplinary intervention during follow‐up in BCS and identify variables related to improvements in HRQoL.Materials and MethodsIn a non‐randomised quasi‐experimental design performed on an outpatient basis in a hospital gynaecology and oncology unit, 60 BCS were assigned to an interdisciplinary experimental group (EG) or a usual care group (CG). The EG underwent 12 sessions of an interdisciplinary program which included Mindfulness and physiotherapy, for 120 min per day, once a week for 6 weeks. At baseline, at 6 weeks and at 3 months after the intervention, participants of EG and CG completed an assessment of HRQoL (EuroQol and EORTC‐QLQ‐C30) and symptomatology of anxiety and depression. Additionally, EG completed an assessment of satisfaction with the treatment. For data analysis, we used descriptive statistics, Wilcoxon test, Kruskal–Wallis test, Chi‐square and Fisher tests and generalised linear models.ResultsAfter 6 weeks, statistically significant differences were apparent in global and cancer‐related health symptoms such as fatigue and pain in the EORTC QLQ‐C30 and in anxiety and depression, among the EG (n = 30) compared with the CG (n = 30). Patients receiving the intervention reported a high degree of satisfaction with the treatment. Three months after the intervention, patients in the EG continued to show statistically significant improvements compared with the CG. In addition, allocation to the EG was identified as a variable related to improvement of HRQoL (EORTC QLQ‐C30) in the multivariable model.ConclusionsThe results of our study suggest that a 6‐week interdisciplinary intervention may improve HRQoL and symptomatology of anxiety and depression in BCS patients at 3 months. The study presents data that the intervention for BCS appears promising and warrants further study in a randomised controlled trial.
The effect of propofol on chemosensitivity of paclitaxel in cervical cancer cells
Authors: Jin Yanshan , Xie Shangdan , Sheng Bo , Chen Mei , Zhu Xueqiong 
Published: May 2023

AbstractBackgroundPropofol is a drug with potential anticancer effect. This study aimed to explore the effect of propofol on chemosensitivity of cervical cancer cells to paclitaxel.MethodsHeLa and CaSki cells were selected for drug experiments. Cell viability was evaluated via CCK‐8 assay, and the combination index (CI) was calculated by CompuSyn software. A clinically relevant concentration and IC30 of propofol were selected in combination with 5 nM paclitaxel. BrdU incorporation, transwell, and flow cytometry assays were utilized to evaluate cell proliferation, migration, invasion, and apoptosis. The expression of β‐tubulin, stathmin 1, and GAPDH proteins was evaluated by Western blot. The stathmin 1 cDNA plasmid was used to establish stathmin 1‐overexpressing CaSki cells.ResultsAt clinically relevant concentrations (0–80 μM), propofol did not affect cancer cell viability, but high concentrations (100–800 μM) reduced cell viability. The CI values of propofol with IC30 (200 μM in HeLa; 400 μM in CaSki) combined with 5 nM paclitaxel were <1. The effect of propofol with IC30 combined with paclitaxel on cell proliferation, migration, invasion, and apoptosis were stronger than individual effect, while 30 μM propofol had no effect. The Western blot results showed 30 μM propofol did not affect β‐tubulin and stathmin 1 expression in cells, although paclitaxel upregulated β‐tubulin expression while downregulating stathmin 1 expression. Compared with paclitaxel alone, cotreatment with propofol at its IC30 and paclitaxel decreased stathmin 1 expression but had no effect on β‐tubulin expression. High stathmin 1 expression weakened the effect of paclitaxel on cell viability and apoptosis, while propofol partially reversed these effect.ConclusionPropofol at clinically relevant concentrations had no effect on the malignant biological behaviors of cervical cancer cells, while propofol at high concentrations decreased.Propofol with IC30 and paclitaxel had synergetic effect on cancer cells through a reduction in stathmin 1 expression.
Retrograde percutaneous coronary intervention of chronic total occlusion via discontinuous septal channels
Authors: Zhang Yao‐Jun , Ma Wen‐Rui , Xu Bo , Huang Ze‐Han , Zhang Xiao‐Yong , Iqbal Javaid , Dou Ke‐Fei , Bourantas Christos V. , Werner Gerald S. , Zhang Bin 
Published: May 2023

AbstractObjectivesThe study aims to investigate the safety and feasibility of retrograde CTO intervention via collateral connection grade 0 (CC‐0) septal channel and to identify predictors of collateral tracking failure.BackgroundGuidewire crossing a collateral channel is a critical step for successful retrograde percutaneous coronary intervention (PCI) of chronic total occlusion (CTO).MethodsRetrograde PCI was attempted in 122 cases of CTO with CC‐0 septal collaterals from December 2018 to May 2021. A hydrophilic polymer coating guidewire was used for crossing all intended CC‐0 collaterals. A multivariable logistic regression analysis was performed to identify the predictors of guidewire tracking failure via the CC‐0 collaterals.ResultsSuccessful guidewire tracking via CC‐0 septal channel was achieved in 98 (80.3%) of 122 cases. The independent predictors of CC‐0 septal channel guidewire tracking failure included well‐developed non‐septal collateral (OR: 5.297, 95% CI: 1.107–25.353,p = 0.037) and the ratio length of posterior descending artery (PDA) versus the distance of PDA ostium to cardiac apex ≤2/3 (OR: 3.970, 95% CI: 1.454–10.835,p = 0.007). Collateral perforation, target vessel perforation, and cardiac tamponade occurred in 5 (4.1%), 3 (2.5%), and 6 (4.9%) cases, respectively. There were no complications requiring emergency cardiac surgery or revascularization of nontarget vessel.ConclusionsRetrograde PCI via CC‐0 septal channels with a hydrophilic polymer‐coated guidewire is feasible and safe in patients with CTO. Well‐developed nonseptal collaterals and short PDA length influence the procedure success and the risk of guidewire tracking failure via CC‐0 septal channels.
Transcatheter edge‐to‐edge mitral valve repair for post‐myocardial infarction papillary muscle rupture and acute heart failure: A systematic review
Authors: Calì Filippo , Pagnesi Matteo , Pezzola Elisa , Montisci Andrea , Metra Marco , Adamo Marianna 
Published: May 2023

AbstractPapillary muscle rupture (PMR) is a rare complication of acute myocardial infarction (AMI) associated with high mortality and morbidity. Surgery is the gold‐standard treatment for these patients, but it is burdened by a high perioperative risk due to hemodynamic instability. Mitral transcatheter edge‐to‐edge repair (M‐TEER) was reported to be safe and effective in unstable patients with significant mitral regurgitation. However, data in patients with post‐AMI PMR are limited to a few case reports. In this review, we summarized all data available regarding percutaneous treatment of post‐AMI PMR. These results show that M‐TEER is safe and effective in this setting with low in‐hospital mortality and complications and high rate of significant mitral regurgitation reduction.
Improving accuracy of summation using parallel vectorized Kahan's and Gill‐Møller algorithms
Authors: Dmitruk Beata , Stpiczyński Przemysław 
Published: May 2023

AbstractThe aim of this paper is to show that Kahan's and Gill‐Møller compensated summation algorithms that allow to achieve high accuracy of summing long sequences of floating‐point numbers can be efficiently vectorized and parallelized using Intel AVX‐512 intrinsics together with OpenMP constructs in order to utilize SIMD extension of modern multicore processors. Numerical experiments show that the new implementations of the algorithms achieve much better accuracy than ordinary summation in both double and single precision and their performance is comparable with the performance of the ordinary summation algorithm optimized automatically. The vectorized Gill‐Møller algorithm is faster than the vectorized Kahan's algorithm. However, in case of single precision, the accuracy of the Gill‐Møller algorithm is worse than Kahan's but it can be fixed by the use of mixed‐precision. Then the accuracy of both compensated summation algorithms is the same and the Gill‐Møller algorithm is still faster than Kahan's.
Rough DT2R2ML for renewable energy supplier selection in the presence of big data
Authors: Fazlollahtabar Hamed 
Published: May 2023

SummarySupplier selection is a substantial problem in supply chain management due to concurrent decision on key performance indicators on multi‐dimension data. Recently, more studies investigated the supplier section problem with respect to variety of criteria within the contexts of applied cases. The problem is more significant when industries with high amount of investment explore appropriate suppliers such as renewable energy. This article concerns with developing a new method encompass all indices effective on supplier selection. The proposed algorithm first group by decision tree (DT) indices to criteria and sub‐criteria; then, to include large amount of uncertain data, rough comparisons and weighing are fulfilled using a machine learning (RML). Further, transformation (T) to crisp value and ranking (R) of suppliers are delivered. The new method is implemented for a renewable energy supplier selection problem as a case study. The outputs show the effectiveness of the proposed method in practice since it can handle big data through a machine learning technique. Managerial implications as decision supports are discussed.
Optimized Workflow for Whole Genome and Transcriptome Next‐Generation Sequencing of Single Cells or Limited Nucleic Acid Samples
Authors: Andreou Ioanna , Storbeck Markus , Hahn Peter , Rulli Samuel , Lader Eric 
Published: May 2023

AbstractWhole genome and whole transcriptome sequencing require orders of magnitude more of starting nucleic acid than what is found in single cells or other extremely limited samples. High fidelity amplification of this minute amount of nucleic acids is essential to overcome the limitations caused by the low input, degradation and contamination, and to ensure a sufficient amount of DNA for preparation of high complex and high quality next‐generation sequencing (NGS) libraries. Recent technical advances in multiple displacement amplification (MDA) enable studies of rare cell types, heterogeneity of body fluids, tissues, environmental samples, and organisms that cannot be cultured. Several strategies for amplification of limiting amounts of nucleic acid have been described, with PCR being popular. However, PCR‐based methods result in high error rates, lower library complexity, and lower coverage uniformity. In this article, a HiFi MDA is used to accurately amplify the limited material and to allow library preparation starting from high input, while reducing PCR cycling to achieve sufficient library yields. This article describes a complete workflow from cells and small quantities of DNA or RNA to NGS libraries for Illumina sequencing instruments. © 2023 QIAGEN GmbH. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Whole genome amplification from single cellsSupport Protocol 1: PicoGreen™ quantification of MDA amplified DNASupport Protocol 2: Purification of amplified DNA after MDABasic Protocol 2: Whole transcriptome amplification from single cellsAlternate Protocol: Whole transcriptome amplification from purified RNABasic Protocol 3: Enrichment of complete small genomes using target‐specific primers in MDABasic Protocol 4: Complete viral RNA amplification using target‐specific primers in MDABasic Protocol 5: Enzymatic fragmentation and adapter ligation of MDA amplified materialBasic Protocol 6: Normalization of library concentration using magnetic beads
A Rapid Method to Determine Growth‐Limiting Nutrient Concentrations for Yeast in a Microplate Spectrophotometer
Authors: Lewis Alisha G. , Gibney Patrick A. 
Published: May 2023

AbstractDetermining the minimal concentration of a substance—whether a compound used to inhibit cell growth or a growth‐limiting nutrient—can be an arduous process. Carrying out the experiment in flasks or tubes and estimating cell density in a single‐sample spectrophotometer has been a routine method of choice due to the ease of measurement and standardized conversions from optical density measurements to cell concentrations. However, when dealing with dozens or more samples, several challenges arise, including increased processing time, increased risk of contamination through repeated sampling, and an increased risk of confounding one sample for another. The protocol described here details a rapid method to estimate cell concentrations for such experiments using a microplate spectrophotometer. Using a microplate spectrophotometer to measure optical density of many cultures can be automated for high throughput and benefits from a reduced risk of contamination. Since one of the caveats of a microplate spectrophotometer is its low saturation limit, we further describe how to convert optical density readings of the microplate spectrophotometer into its single‐sample spectrophotometric equivalent. To further illustrate the applicability of this protocol, we compare OD600 readings generated using a microplate spectrophotometer and a single‐sample spectrophotometer for different nutrient starvations and show that the results are comparable. Overall, this method reduces the required resources, reduces the risk of contamination, and allows for faster processing of samples. © 2023 Wiley Periodicals LLC.Basic Protocol 1: Generating an equation to convert microplate spectrophotometer readings to single‐sample spectrophotometric valuesBasic Protocol 2: Evaluating growth‐limiting nutrient concentrations using a microplate spectrophotometer