bluuebunny/crossref_metadata_2025_split huggingface dataset:
The CTCF-H3K27me3 axis supports melanoma cell migration by repressing cholesterol biosynthesis
Authors: Kaczmarczyk Lukasz Stanislaw , Levi Nehora , Salmon-Divon Mali , Gerlitz Gabi 
Published: February 2023

AbstractCTCF is a key factor in three-dimensional chromatin folding and transcriptional control that was found to affect cancer cell migration by a mechanism that is still poorly understood. To identify this mechanism, we used mouse melanoma cells with a partial loss of function (pLoF) of CTCF. We found that CTCF pLoF inhibits cell migration rate while leading to an increase in the expression of multiple enzymes in the cholesterol biosynthesis pathway along with an elevation in the cellular cholesterol levels. Inhibition of cholesterol synthesis in CTCF pLoF cells restored the cellular migration rate, suggesting that CTCF supports cell migration by suppressing cholesterol synthesis. Detailed analysis of the promoter ofHmgcs1, an early enzyme in the cholesterol synthesis pathway, revealed that CTCF enables PRC2 recruitment to the promoter and deposition of H3K27me3 to prevent SREBP2 binding and activation of transcription. By this mechanism CTCF fine-tunes cholesterol levels to support cell migration. Notably, genome wide association studies suggest a link between CTCF and cholesterol-associated diseases, thus CTCF emerges as a new regulator of cholesterol biosynthesis.
Effect of tuft-IL-25-ILC2 pathway on mouse small intestine stimulated byTrichinella spiralisES antigen
Authors: Jie Bai , Ling HE , Jureti Napisha 
Published: February 2023

AbstractObjectiveTo explore the regulatory effect ofTrichinella spiralisES antigen on the intestinal immune function, we observed the immune response of mouse small intestine to this antigen by quantifying the changes in the related cytokines of Tuft-IL-25-ILC2 pathway.MethodsA total of 30 BALB/c female mice were randomly divided into three groups: control group,Trichinellaexcretion-secretion (ES) antigen stimulation group, and IL-25 blocking group. The mice in the control group were injected intraperitoneally with PBS; those in the ES antigen stimulation group were injected intraperitoneally with ES antigen once per day for 7 consecutive days; and those in the IL-25 blocking group were injected intraperitoneally, first with anti-mouse IL-25 monoclonal antibody and 3 days later with ES antigen. Alcian blue-nuclear fast red staining was employed to observe the changes in the number of small intestinal goblet cells. The number of Tuft cells was determined by immunofluorescence chemical analysis, and the expression levels of IL-25, IL-13, IL-25R, Pou2f3, and RORα mRNA were quantified by RT-PCR.Key resultsThe results of Alcian blue-nuclear fast red staining showed that, compared with the control group, the number of goblet cells in the small intestinal tissue of mice in the ES antigen stimulation group increased, and the difference was statistically significant (P<0.05). Compared with the ES antigen stimulation group, the number of goblet cells in the small intestinal tissue of the mice in the IL-25 blocking group was slightly decreased (P<0.05). Immunofluorescence analysis showed that, compared with the control group, the number of Tuft cells in the ES antigen-stimulated group increased (P<0.05), while in the IL-25 blocking group, the number of Tuft cells was decreased compared with that in the ES antigen stimulation group (P<0.05). RT-PCR analysis showed that, compared with the control group, the mRNA expression levels of IL-25, IL-13, IL- 25R, RORαand Pou2f3 in the small intestine of mice in the ES antigen stimulation group were increased (P<0.05); compared with the ES antigen stimulation group, the IL-25, IL-13, IL-25R, RORαand Pou2f3 mRNA expressions in the tissues of the mice in the IL-25 blocking group were decreased, and the difference was statistically significant (P<0.05).ConclusionThe small intestinal mucosa of mice stimulated byTrichinellaES antigen may possess an immune function via the Tuft-IL-25-ILC2 pathway.
Assessing GIS education and GIS workforce in Saudi Arabia
Authors: Alrwais Omer 
Published: February 2023

PurposeThe geographic information systems (GIS) sector is witnessing significant growth in recent times at the global level and in the Kingdom of Saudi Arabia at the same pace. In this research, the authors aim to measure the GIS market employability in the Kingdom of Saudi Arabia, the required skills of those seeking GIS employees, existing knowledge and abilities of graduates of relevant academic programs and gaps, if any, between the graduates and the labor market requirements in terms of GIS. Research on GIS education and GIS employability from an information system perspective is scarce; thus, this study is needed.Design/methodology/approachIn this study, a questionnaire was distributed manually and electronically to a specific group of GIS students, teachers and employees. The questionnaire was prepared in Arabic and English language. It was distributed manually to the attendees of the 12th GIS Symposium, organized by Imam Abdulrahman Bin Faisal University at Dammam city, Saudi Arabia in April of 2018. The event is a yearly one that gathers local GIS community and outside speakers and guests. An electronic version of the questionnaire was also available and distributed via personal contacts. Responses were received until the end of 2019.FindingsThe results of 107 respondents indicates good GIS foundation (for example in topology, geospatial data processing and cartography); however, programming and business skills (namely cost benefit analysis, organizational perspective and business understanding) are lacking from Saudi GIS graduates. About 67% of respondents acknowledge directly that it is difficult to find locally qualified GIS graduates. Moreover, 55% of respondents classify GIS job candidates as underqualified. This research identifies under qualification in business competencies and computer programming skills for GIS students and workers in Saudi Arabia. This research did not find a statistically significant different response between GIS teachers and GIS employees/employers; however, students’ response was significantly different from these two groups.Originality/valueResearch on GIS education and GIS employability from an Information System perspective is scarce; thus, this study is needed. Moreover, research about this topic in Saudi Arabia and the Arabian Gulf is almost nonexistent.
The performance of business groups during institutional transition and economic downturn in a developing country
Authors: Bhutta Aamir Inam , Sultan Jahanzaib , Sheikh Muhammad Fayyaz , Sajid Muhammad , Mushtaq Rizwan 
Published: February 2023

PurposePakistan has experienced financial liberalization with rapid ups and downs in economic growth due to domestic issues during the last 2 decades. Motivated by inconclusive and conflicting time-driven findings about the performance of the business groups, this study examines the performance of business groups in Pakistan for a relatively long period from 2003 to 2018.Design/methodology/approachThe study uses 3,821 firm-year observations from non-financial firms listed on the Pakistan Stock Exchange (PSX). For the estimation, pooled ordinary least squares (OLS) with industry- and year fixed effects and two-step system generalized methods of moments (GMM) are used.FindingsThe study finds that group-affiliated firms outperform independent firms in accounting performance, while underperform in market performance. The outperformance is mainly driven by medium-sized business groups, while underperformance is driven by small and large business groups. Further, the study documents that the underperformance in terms of market performance of firms affiliated with small and large groups is greater before the economic downturn, while outperformance in terms of the accounting measure of firms affiliated with medium-sized groups is greater during the economic downturn. These findings support our time-driven concerns. Overall, the authors' findings are consistent with institutional and transaction cost theories.Practical implicationsBusiness groups are important channels to reduce market inefficiencies. Business groups may enhance the affiliated firms' resources and resistance capacity through active utilization of the internal capital market, specifically when market conditions are not ideal for affiliates. However, effective utilization of internal capital markets depends on group size. Therefore, investors should deliberate on the size of business groups and diversification within business groups.Originality/valueThe authors extend the literature by providing fresh evidence related to the performance of business groups in the Pakistani context while accounting for the role of the size of business groups.
Panacea or poison? Exploring the paradoxical problematizations of loneliness, technology and youth in Norwegian and UK policymaking
Authors: Jentoft Elian Eve , Haldar Marit 
Published: February 2023

PurposeLoneliness’ impact on health and wellbeing has emerged as a public health issue in several countries. Young people are increasingly understood as a ‘risk group’ and intervention target for loneliness-reduction. This research paper aims to present a discourse analysis of policies and political speech about young people and loneliness.Design/methodology/approachUsing discourse analysis inspired by Carol Bacchi’s “What is the Problem Represented to Be” (WPR) approach, this cross-cultural analysis studies loneliness policy in the United Kingdom (UK) and Norway. In doing so, the authors ask: What is the problem of loneliness among young people represented to be in UK and Norwegian welfare policy?FindingsThe findings indicate paradoxical problematizations of the role technology plays among lonely young people, who, in this context, are divided in two categories: able normative and disabled youth. We reveal fundamental differences in beliefs about the impact of technology on these groups, and corresponding differences in the proposed solutions. The problem of young peoples’ loneliness is represented as uncertainty about potential harms of digital connectedness and reduced face-to-face interactions. In contrast, the problem of loneliness among disabled youth is represented as impeded access to social realms, with technology serving a benign role as equalizer.Originality/valueLittle research has examined this new policy field. The article contributes to filling this gap and encourages policymakers to consider how political discourses on loneliness may lead them to overlook digital interventions young people could find beneficial.
A bibliometric analysis of political connections literature
Authors: Ahmed Fatma , Hussainey Khaled 
Published: February 2023

PurposeThis paper aims to present a catalogue of the influential aspects resulting from a bibliometric meta-analysis of political connection literature.Design/methodology/approachThis study undertakes a bibliometric meta-analysis review of political connections literature, covering 138 research papers from 2000 to 2020 using the visualization of similarities viewer program.FindingsThe authors identify six research groups: the value of political connections; political connections and finance; political connections in banks; political connections and debt; management and political connections; and political connections and governance. This study discusses each stream through a cartographic analysis, including co-authorship, countries and time networks.Originality/valueThis study makes an important and novel contribution to political connection literature. So far, to the best of the authors’ knowledge, it is the only bibliometric study on political connections. This study is the first to use network analysis and community detection to understand social clustering and to identify main research steams in political connection literature.
Sustainable apparel: a perspective from Bangladesh’s young consumers
Authors: Su Jin , Iqbal Md Arif , Haque Farhan , Akter Maeen Md Khairul 
Published: February 2023

Purpose
This study aims to understand Bangladeshi young consumers’ perceptions of sustainable apparel. Specifically, through the lens of the theory of reasoned action (TRA), this study investigates the impacts of man–nature orientation (MNO) and social influences on Bangladeshi young consumers’ intention to purchase sustainable apparel.

Design/methodology/approach
Empirical survey-based research was conducted, and data were collected from 387 Bangladeshi college students.

Findings
The findings of the study show that MNO significantly influences Bangladeshi young consumers’ attitudes toward purchasing sustainable apparel, which, together with social influences, impacts young Bangladeshi consumers’ intention of making efforts to purchase sustainable apparel.

Originality/value
This study incorporates the specific cultural value – MNO with the traditional TRA model to understand young Bangladeshi consumers’ sustainable apparel purchase intention. The results of this study demonstrate the applicability of the TRA framework in understanding young consumers’ sustainable apparel consumer behavior in the context of Bangladesh, which is a developing country with a collectivistic culture. This study provides insights into how apparel brands and retailers should design their sustainability strategies in developing countries such as Bangladesh.
How The TQM Journal has addressed “quality”: a literature review using bibliometric analysis
Authors: Shrivastav Santosh Kumar 
Published: February 2023

PurposeThis study investigates the overall publications of The TQM Journal since its inception with an aim to identify the trending topics and emerging trends.Design/methodology/approachThe quantitative bibliometric and social network analysis techniques composed of keywords, co-occurrence network and keyword cluster detection are employed to conduct the investigation. A total of 968 papers published in The TQM Journal till August 2022 were sourced from the SCOPUS database to conduct the analysis.FindingsThe research identifies five themes from the published articles namely, customer service experience and satisfaction; quality management and organizational performance; quality measurement tools and models; quality and sustainable development; and quality and competitive advantage. The study also identifies the most significant articles, authors and countries published in the journal and shows that Industry 4.0 is the trending topic and quality 4.0 the new emerging trend in the journal.Research limitations/implicationsThe analysis is carried out only for papers published in The TQM Journal till August 2022; those after this month are not included in the analysis. The outcome of this study is dynamic in nature and subject to change over time as more papers, citations and collaborations are added to the list.Originality/valueThis is the first article of its kind to explore The TQM Journal publications with an aim to identify trending and emerging topics and also the most valuable authors based on the number of publications and citations through the bibliometric analysis.
Dementia’s preventative futures: researcher perspectives on prospective developments in the UK
Authors: Fahey Miriam , Tinker Anthea , Fletcher James Rupert 
Published: February 2023

Purpose
In lieu of a cure, the idea that dementia might be preventable through risk-factor moderation has latterly gained popularity. Prevention research is an evolving field that will likely undergo significant shifts in the near future. This paper aims to engage with that future as it is imagined in the present.

Design/methodology/approach
This study explores the futures envisaged by dementia prevention researchers in the UK, based on interviews with six practitioners at the forefront of the field.

Findings
Participants foresaw a pivot away from “dementia prevention” toward “brain health”, and advocated for blended policy, community and lifestyle interventions. They were excited by the prospects for a lifecourse dementia hypothesis to inform new interventions but uncomfortable with the ethics of early intervention.

Originality/value
These findings complicate simplistic depictions of prevention researchers as pursuing responsibilised lifestyle approaches.
Review: Biogeographic and environmental history of Fagus and beech‐dominant forest in Japan
Authors: Momohara Arata , Ito Ayano 
Published: February 2023

AbstractThere is a rich beech fossil record in Japan dating from the Paleogene to the Holocene, which allows for the continuous tracing of the evolutionary history of the genus and allows us to understand the environmental background that facilitated the genus to obtain a dominant state in present‐day forests. In addition to the temperate climate, the oceanic climate was an important factor in controlling beech distribution and dominance in the forests in Japan. With the cooling climate, beech species began expanding their distribution in the Northern Hemisphere in the middle Eocene and appeared in Japan in the late middle Eocene. Beech species became dominant in forests in Japan during the Miocene along with the development of the oceanic climate by the opening of the Sea of Japan and with the strengthening of the monsoon. Fagus crenata appeared until the Late Pliocene and became dominant in forests in central Japan in the late Early Pleistocene coinciding with the onsetting inflow of the Tsushima Warm Current to the Sea of Japan in interglacial stages. During the full‐glacial stages since the late Middle Pleistocene, the cold and dry climate caused by the strong winter monsoon limited the distribution of beeches into refugia at humid places, including the inland. During the deglaciation since ca 19 ka, the beech population began to grow and its distribution expanded, controlled by the development of the Tsushima Warm Current, as well as latitudinal and altitudinal temperature clines.
Moscow's Outreach to Hanoi: Artistic Ties between the Soviet Union and Vietnam
Authors: Kraevskaia Natalia , Taylor Nora Annesley 
Published: February 2023

In the 1960s through the 1970s, and afterwards, a number of Vietnamese artists travelled to the Soviet Union to study at prestigious Soviet art and film academies. While Vietnamese artists did not develop a considerable body of work that can match the grandiose works of socialist realism under Josef Stalin, some artists did work in a socialist realist style that merged academic oil painting styles with local themes. This essay examines the work of Vũ Duy Nghı̃a (1935–2022), Lê Huy Tiếp (b. 1950) and Đào Châu Hải (b. 1955), who studied in the Soviet Union during this period and integrated various painting methods, styles and techniques into their art works. The legacy of Soviet–Vietnam relations is a still largely understudied field. While archival sources are difficult to access, the essay relies on interviews with two of the living artists. It looks into the significance of studying in the Soviet Union for these art workers, and assesses the impact that it had on the development of Vietnamese culture overall.
Interacting arguments in crisis communication: The influence of message convergence on risk and crisis messages
Authors: Soares Rodrigo , Jin Xianlin , Spence Patric R. , Sellnow Timothy L. 
Published: February 2023

AbstractBy their nature, risks, and crises create uncertainty. This uncertainty causes both discomfort and confusion for those seeking to protect themselves and their loved ones from the threat at hand. As more information is revealed about a risk or crisis, interacting arguments often coalesce to reveal points or convergence. This exploratory study examined the relationships among message convergence and the desire to seek additional information, source credibility, risk severity, and perceptions of message consistency in response to a notable risk to the food supply. Results indicated that those participants viewing content with high convergence had heightened perceptions of source credibility, risk severity, and message consistency. They did not, however, indicate a need to seek further information. These results suggest that organizations and agencies offering warnings about risks and crises can benefit from message convergence.
Current and future interventions for improving poultry health and poultry food safety and security: A comprehensive review
Authors: Chowdhury Md. Anamul Hasan , Ashrafudoulla Md. , Mevo Senakpon Isaïe Ulrich , Mizan Md. Furkanur Rahaman , Park Si Hong , Ha Sang‐Do 
Published: February 2023

AbstractPoultry is thriving across the globe. Chicken meat is the most preferred poultry worldwide, and its popularity is increasing. However, poultry also threatens human hygiene, especially as a fomite of infectious diseases caused by the major foodborne pathogens (Campylobacter,Salmonella, andListeria). Preventing pathogenic bacterial biofilm is crucial in the chicken industry due to increasing food safety hazards caused by recurring contamination and the rapid degradation of meat, as well as the increased resistance of bacteria to cleaning and disinfection procedures commonly used in chicken processing plants. To address this, various innovative and promising strategies to combat bacterial resistance and biofilm are emerging to improve food safety and quality and extend shelf‐life. In particular, natural compounds are attractive because of their potential antimicrobial activities. Natural compounds can also boost the immune system and improve poultry health and performance. In addition to phytochemicals, bacteriophages, nanoparticles, coatings, enzymes, and probiotics represent unique and environmentally friendly strategies in the poultry processing industry to prevent foodborne pathogens from reaching the consumer. Lactoferrin, bacteriocin, antimicrobial peptides, cell‐free supernatants, and biosurfactants are also of considerable interest for their prospective application as natural antimicrobials for improving the safety of raw poultry meat. This review aims to describe the feasibility of these proposed strategies and provide an overview of recent published evidences to control microorganisms in the poultry industry, considering the human health, food safety, and economic aspects of poultry production.
The dominant species of natural enemies of Pentatomidae in the peak period
Authors: Chen Shiyan , Cheng Honghao , Wu Xiaomeng , Xu Yue , Zou Yunding , Bi Shoudong 
Published: February 2023

AbstractThis paper aims to analyse how to effectively protect and scientifically utilize the natural enemies of Pentatomidae in tea plantations in the peak period. In this paper, the spatial, quantitative and temporal relationships between Pentatomidae and its natural enemies in “Pingyangtezao”, “Wuniuzao”, “Huangshandayezhong”, “Anjibaicha”,”Longjing 43″ and “Nongkangzao” tea gardens in Hefei, China were comprehensively compared and analyzed with the methods of geostatistical analysis, gray system analysis and temporal ecotone overlap index analysis. According to the size of the closeness index, the top three natural enemies with the largest sum of spatial, quantitative, and temporal closeness indexes in the six tea gardens were Clubiona japonicola (X7, 16.514), Oxyopes sertatus (X5, 16.390) and Xysticus ephippiafus (X2, 16.270). The size of the ratio between the number of Pentatomidae individuals and natural enemies largely determines whether the natural enemies follow Pentatomidae pests closely or not. The better the growth of tea plantations and the richer the diversity of pest species, the more accurately the predation preference of natural enemies can be reflected. In the control of Pentatomidae, specific analysis should be made according to the occurrence characteristics of target pests in different tea plantations and the basic attributes of tea plantations (species, growth, population characteristics of natural enemies and pests, etc.) in order to scientifically utilize its natural enemies.