bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haddis Alemayehu’s Vision of the Old World: Literary Realism and the Tragedy of History in the Amharic NovelFikir iske Mekabir
Authors: Ayele Tesfaye Woubshet 
Published: September 2023

AbstractHaddis Alemayehu’s classic novelፍቅር እስከ መቃብር(Fikir iske Mekabir,Love until Death, 1958 Ethiopian Calendar, 1965/6 Gregorian Calendar), is lauded by critics as a pioneering realist and modern novel in the Amharic literary tradition. My aim in this article is to scrutinize this take by examining the novel’s narrative temporalities and modes through a dialectical lens. This leads me to argue that the novel’s realism is marked by contradiction and fluidity. Specifically, the emergence of realism inFikir iske Mekabiris accompanied by its breakdown while the realist narrative mode is accompanied by the traditional narrative modes of epic and hagiography (or,gedl).This hitherto unexamined textual and intertextual quality of Haddis’s novel reveals new insights into its thematic content regarding modernity, tradition, and social reproduction under the old Ethiopian order.
Harnessing length and height changes in thermoresponsive programmable materials
Authors: Chalissery Dilip , Rümmler Tobias , Ziervogel Fabian , Eberl Chris , Pretsch Thorsten 
Published: September 2023

Abstract
Shape-memory polymers can be used to develop thermoresponsive programmable materials that can take on sensory and actuator tasks as their ambient temperature changes. In this contribution, a self-synthesised poly(1,10-decylene adipate) diol-based polyester urethane (PEU) was used for their fabrication. After processing the PEU into filaments, programmable materials, including a gear-like object, the teeth of a ‘bevel gear’ and a unit cell, were additively manufactured by fused filament fabrication. In any case, a thermomechanical treatment was conducted that involved the deformation of the polymer at 75°C. After cooling to 15°C, the programmable materials were unloaded and the thermoresponsiveness between 23°C and 58°C was investigated. A maximum thermoreversible change in height of about 39% was detected for the ‘gear’. With regard to the ‘bevel gear’, proof of feasibility was provided for use as overheating protection, so that a force transmission could be switched off when heated and switched on when cooled down. The unit cell actuated under a weak external load of 0.01 N, thus exhibiting thermoreversible length changes of about 45%.
A report on the complete mitochondrial genome of the trematode Azygia robusta Odhner, 1911, its new definitive host from the Russian Far East, and unexpected phylogeny of Azygiidae within Digenea, as inferred from mitogenome sequences
Authors: Atopkin D. M. , Semenchenko A. A. , Solodovnik D. A. , Ivashko Y. I. 
Published: September 2023

Abstract
New data on the complete mitochondrial genome of Azygia robusta (Azygiidae) were obtained by the next-generation sequencing (NGS) approach. The mitochondrial DNA (mtDNA) of A. robusta had a length of 13 857 bp and included 12 protein-coding genes, two ribosomal genes, 22 transfer RNA genes, and two non-coding regions. The nucleotide sequences of the complete mitochondrial genomes of two A. robusta specimens differed from each other by 0.12 ± 0.03%. Six of 12 protein-coding genes demonstrated intraspecific variation. The difference between the nucleotide sequences of the complete mitochondrial genomes of A. robusta and Azygia hwangtsiyui was 26.95 ± 0.35%; the interspecific variation of protein-coding genes between A. robusta and A. hwangtsiyui ranged from 20.5 ± 0.9% (cox1) to 30.7 ± 1.2% (nad5). The observed gene arrangement in the mtDNA sequence of A. robusta was identical to that of A. hwangtsiyui. Codon usage and amino acid frequencies were highly similar between A. robusta and A. hwangtsiyui. The results of phylogenetic analyses based on mtDNA protein-coding regions showed that A. robusta is closely related to A. hwangtsiyui (belonging to the same suborder, Azygiida) that formed a distinct early-diverging branch relative to all other Digenea. A preliminary morphological analysis of paratypes of the two azygiid specimens studied showed visible morphological differences between them. The specimen extracted from Sakhalin taimen (Parahucho perryi) was most similar to A. robusta. Thus, we here provide the first record of a new definitive host, P. perryi, for A. robusta and also molecular characteristics of the trematode specimens.
Differenzielle Befunde zur Sprachentwicklung im Jugendalter in ausgewählten diagnostischen Aufgaben des LSI.J Sprachtest-Tablets
Authors: Glück Christian W. , Kessler Ruth , Pino Danielle , Scheithauer Bettina , Wagner Susanne , Krause Carina D. 
Published: September 2023

Zusammenfassung: Theoretischer Hintergrund: Da der Bildungserfolg stark von den Sprachkompetenzen abhängt, sind Kenntnisse zur Sprachentwicklung auch im Jugendalter zur Ableitung diagnostischer und unterstützender Strategien bedeutsam. Fragestellung: Die Studie versucht eine differenzielle Einschätzung der Sprachentwicklung mit Blick auf den Schulabschluss und das Alter anhand von Aufgabenstellungen aus der klinischen Diagnostik. Methode: In einer Stichprobe Jugendlicher ( N = 147, deutschsprachig, ohne bekannte Sprachstörung, Alter 17 – 22 Jahre, verschiedene Schularten) wurden Tests zum dichotischen Hören, Schnellbenennen, Sätze-Verstehen und Verstehen figurativer Sprache des Leipziger Sprachinstrumentariums Jugend (LSI.J) vorgelegt 1 . Ergebnisse: Regressionsmodelle zeigen einen starken Einfluss des Prädiktors Schulabschluss – nicht jedoch des Prädiktors Alter. Diskussion und Schlussfolgerung: Diskutiert werden die Anforderungen der diagnostischen Aufgaben, der Einfluss des Bildungskontexts und die Bildungschancen von mehrsprachigen Jugendlichen oder Jugendlichen mit Sprachentwicklungsstörungen.
Statistical Study of the Nonthermal Continuum Radiation Beaming Angle Measured by the High Frequency Receiver on Van Allen Probes‐A
Authors: Boardsen S. A. , Kim E.‐H. , Green J. L. , Cheng C. Z. , Cairns I. H. , Johnson J. R. 
Published: September 2023

AbstractThe nonthermal continuum (NTC) radiation beaming angle is computed over the entire Van Allen Probes‐A mission when the spacecraft was in the dawn sector. The conditions in the dawn sector are favorable for the wave vector to lie near/in the spacecraft's spin plane allowing a favorable estimate of the beaming angle, and the dawn sector is also advantageous in that previous studies show NTC occurrence to peak in this sector. We found that scatter plots, over the entire mission, of beaming angle versus magnetic latitude form a distinct inverted‐V pattern, with the apex at/near the magnetic equator. This pattern was sharpest for frequencies (f) ≲ 100 kHz. Using the NTC beaming formula from the linear mode conversion theory (LMCT), we show that such an inverted‐V pattern is expected due to the large variation in the plasmapause location over the entire mission. The theoretical derived pattern qualitatively reproduces the observed pattern but not quantitatively. The lack of quantitative agreement is discussed and is attributed to several factors, one factor is off‐centered emissions from the radio window. The qualitative agreement strongly supports LMCT as being the dominant mechanism generating NTC for f ≲ 100 kHz. For f ≳ 100 kHz, the inverted‐V pattern becomes less distinct, and strong near‐equatorial beaming is observed. After considering contamination of our selections by left‐handed polarized AKR, our study suggests that besides LMCT another unidentified NTC generation mechanism becomes important for f ≳ 100 kHz.
Radio Occultation Data Analysis With Analytical Ray‐Tracing
Authors: Caruso A. , Bourgoin A. , Togni A. , Zannoni M. , Tortora P. 
Published: September 2023

AbstractRadio occultation experiments are a sensing technique dedicated to the remote sounding of planetary atmospheres. The technique exploits the frequency shift of a radio signal due to refraction in a planetary atmosphere. The aim is to infer the physical properties of the neutral atmosphere (e.g., pressure and temperature) and ionosphere (e.g., the electron number density). For one‐way occultations, the data processing usually relies on Abel transform algorithms when the atmosphere is spherically symmetric. For two‐way occultations, such techniques require the introduction of approximate relationships for the bending experienced by the signal to be obtained. In this context, we introduce a new method to process two‐way occultations data by spherically symmetric atmospheres using a ray‐tracing approach. However, the numerical integration of the geometrical optics equation through the atmosphere requires a significant computational time due to initial pointing issues. For this reason, our novel algorithm exploits a closed‐form solution to the equations of geometrical optics (Bourgoin et al., A&A, 624, A41, 2019, https://doi.org/10.1051/0004-6361/201834962) applied to a spherically symmetric atmosphere. Within this approach, the bending is directly provided by the analytical solution and no numerical integration is required. In addition, we develop a procedure enabling us to disentangle the contributions from dispersive and neutral media in the frequency shift. This procedure is validated by comparing our vertical profiles to those obtained using Abel inversion or numerical ray‐tracing for Mars and Titan occultation experiments. We show that our algorithm provides similar results to purely numerical ray‐tracing algorithms while significantly decreasing the computational time.
A new era of macrophage-based cell therapy
Authors: Na Yi Rang , Kim Sang Wha , Seok Seung Hyeok 
Published: September 2023

AbstractMacrophages are essential innate immune cells found throughout the body that have protective and pathogenic functions in many diseases. When activated, macrophages can mediate the phagocytosis of dangerous cells or materials and participate in effective tissue regeneration by providing growth factors and anti-inflammatory molecules. Ex vivo-generated macrophages have thus been used in clinical trials as cell-based therapies, and based on their intrinsic characteristics, they outperformed stem cells within specific target diseases. In addition to the old methods of generating naïve or M2 primed macrophages, the recently developed chimeric antigen receptor-macrophages revealed the potential of genetically engineered macrophages for cell therapy. Here, we review the current developmental status of macrophage-based cell therapy. The findings of important clinical and preclinical trials are updated, and patent status is investigated. Additionally, we discuss the limitations and future directions of macrophage-based cell therapy, which will help broaden the potential utility and clinical applications of macrophages.
IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m6A-dependent manner
Authors: Chen Li-Jie , Liu Hui-Ye , Xiao Zhi-Yuan , Qiu Ting , Zhang Dan , Zhang Ling-Jie , Han Fang-Yi , Chen Guo-Jun , Xu Xue-Mei , Zhu Jiong-Hua , Ding Yan-Qing , Wang Shu-Yang , Ye Ya-Ping , Jiao Hong-Li 
Published: September 2023

AbstractInsulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the exact molecular mechanisms of IGF2BP3 in colorectal cancer (CRC) oncogenesis, progression, and drug resistance remain unclear. This study found that IGF2BP3 was upregulated in CRC tissues. Clinically, the elevated IGF2BP3 level is predictive of a poor prognosis. Functionally, IGF2BP3 enhances CRC tumorigenesis and progression both in vitro and in vivo. Mechanistically, IGF2BP3 promotes epidermal growth factor receptor (EGFR) mRNA stability and translation and further activates the EGFR pathway by serving as a reader in an N6-methyladenosine (m6A)-dependent manner by cooperating with METTL14. Furthermore, IGF2BP3 increases the drug resistance of CRC cells to the EGFR-targeted antibody cetuximab. Taken together, our results demonstrated that IGF2BP3 was a functional and clinical oncogene of CRC. Targeting IGF2BP3 and m6A modification may therefore offer rational therapeutic targets for patients with CRC.
Removal of false positives in metagenomics-based taxonomy profiling via targeting Type IIB restriction sites
Authors: Sun Zheng , Liu Jiang , Zhang Meng , Wang Tong , Huang Shi , Weiss Scott T. , Liu Yang-Yu 
Published: September 2023

AbstractAccurate species identification and abundance estimation are critical for the interpretation of whole metagenome sequencing (WMS) data. Yet, existing metagenomic profilers suffer from false-positive identifications, which can account for more than 90% of total identified species. Here, by leveraging species-specific Type IIB restriction endonuclease digestion sites as reference instead of universal markers or whole microbial genomes, we present a metagenomic profiler, MAP2B (MetAgenomic Profiler based on type IIB restriction sites), to resolve those issues. We first illustrate the pitfalls of using relative abundance as the only feature in determining false positives. We then propose a feature set to distinguish false positives from true positives, and using simulated metagenomes from CAMI2, we establish a false-positive recognition model. By benchmarking the performance in metagenomic profiling using a simulation dataset with varying sequencing depth and species richness, we illustrate the superior performance of MAP2B over existing metagenomic profilers in species identification. We further test the performance of MAP2B using real WMS data from an ATCC mock community, confirming its superior precision against sequencing depth. Finally, by leveraging WMS data from an IBD cohort, we demonstrate the taxonomic features generated by MAP2B can better discriminate IBD and predict metabolomic profiles.
Anomalous isotope effect on mechanical properties of single atomic layer Boron Nitride
Authors: Falin Alexey , Lv Haifeng , Janzen Eli , Edgar James H. , Zhang Rui , Qian Dong , Sheu Hwo-Shuenn , Cai Qiran , Gan Wei , Wu Xiaojun , Santos Elton J. G. , Li Lu Hua 
Published: September 2023

AbstractThe ideal mechanical properties and behaviors of materials without the influence of defects are of great fundamental and engineering significance but considered inaccessible. Here, we use single-atom-thin isotopically pure hexagonal boron nitride (hBN) to demonstrate that two-dimensional (2D) materials offer us close-to ideal experimental platforms to study intrinsic mechanical phenomena. The highly delicate isotope effect on the mechanical properties of monolayer hBN is directly measured by indentation: lighter 10B gives rise to higher elasticity and strength than heavier 11B. This anomalous isotope effect establishes that the intrinsic mechanical properties without the effect of defects could be measured, and the so-called ultrafine and normally neglected isotopic perturbation in nuclear charge distribution sometimes plays a more critical role than the isotopic mass effect in the mechanical and other physical properties of materials.
Resilient conductive membrane synthesized by in-situ polymerisation for wearable non-invasive electronics on moving appendages of cyborg insect
Authors: Lin Qifeng , Li Rui , Zhang Feilong , Kai Kazuki , Ong Zong Chen , Chen Xiaodong , Sato Hirotaka 
Published: September 2023

AbstractBy leveraging their high mobility and small size, insects have been combined with microcontrollers to build up cyborg insects for various practical applications. Unfortunately, all current cyborg insects rely on implanted electrodes to control their movement, which causes irreversible damage to their organs and muscles. Here, we develop a non-invasive method for cyborg insects to address above issues, using a conformal electrode with an in-situ polymerized ion-conducting layer and an electron-conducting layer. The neural and locomotion responses to the electrical inductions verify the efficient communication between insects and controllers by the non-invasive method. The precise “S” line following of the cyborg insect further demonstrates its potential in practical navigation. The conformal non-invasive electrodes keep the intactness of the insects while controlling their motion. With the antennae, important olfactory organs of insects preserved, the cyborg insect, in the future, may be endowed with abilities to detect the surrounding environment.
Approach for quick exploration of highly effective broad-spectrum biocontrol strains based on PO8 protein inhibition
Authors: Gu Mei , Fu Jiayun , Yan Honglin , Yue Xiaofeng , Zhao Shancang , Zhang Qi , Li Peiwu 
Published: September 2023

AbstractAflatoxin is a group of strongly toxic and carcinogenic mycotoxins produced by Aspergillus flavus and other Aspergillus species, which caused food contamination and food loss problems widely across the world especially in developing countries, thus threatening human health and sustainable development. So, it is important to develop new, green, and broad-spectrum biocontrol technology for the prevention of aflatoxin contamination sources. Previously, we found that the PO8 protein from aflatoxigenic A. flavus could be used as a biomarker to predict aflatoxin production in peanuts (so the PO8 is named as an early warning molecule), which infers that the PO8 is relative to aflatoxin production. Therefore, in the study, based on inhibiting the PO8, a new and quick strategy for screening aflatoxin biocontrol strains for developing control agents was presented. With the PO8 inhibition method, four biocontrol strains (2 strains were isolated from peanut kernels with sterilized surface and another 2 strains from peanut rhizosphere soil) were selected and combined to increase prevention wide-spectrum. As a result, the combination showed over 90% inhibition to all tested aflatoxigenic A. flavus isolated from three different peanut production areas (north, middle, and south areas of China), and better than any single strain. The field experiments located in five provinces of China showed that the practice prevention effects (inhibition of aflatoxigenic fungi on the surface of the peanuts) were from 50% to over 80%. The results indicated that the strategy of inhibiting the early warning molecule PO8 can be used to develop aflatoxin control agents well.
Applying federated learning to combat food fraud in food supply chains
Authors: Gavai Anand , Bouzembrak Yamine , Mu Wenjuan , Martin Frank , Kaliyaperumal Rajaram , van Soest Johan , Choudhury Ananya , Heringa Jaap , Dekker Andre , Marvin Hans J. P. 
Published: September 2023

AbstractEnsuring safe and healthy food is a big challenge due to the complexity of food supply chains and their vulnerability to many internal and external factors, including food fraud. Recent research has shown that Artificial Intelligence (AI) based algorithms, in particularly data driven Bayesian Network (BN) models, are very suitable as a tool to predict future food fraud and hence allowing food producers to take proper actions to avoid that such problems occur. Such models become even more powerful when data can be used from all actors in the supply chain, but data sharing is hampered by different interests, data security and data privacy. Federated learning (FL) may circumvent these issues as demonstrated in various areas of the life sciences. In this research, we demonstrate the potential of the FL technology for food fraud using a data driven BN, integrating data from different data owners without the data leaving the database of the data owners. To this end, a framework was constructed consisting of three geographically different data stations hosting different datasets on food fraud. Using this framework, a BN algorithm was implemented that was trained on the data of different data stations while the data remained at its physical location abiding by privacy principles. We demonstrated the applicability of the federated BN in food fraud and anticipate that such framework may support stakeholders in the food supply chain for better decision-making regarding food fraud control while still preserving the privacy and confidentiality nature of these data.
Identifying a causal link between prolactin signaling pathways and COVID-19 vaccine-induced menstrual changes
Authors: Hajjo Rima , Momani Ensaf , Sabbah Dima A. , Baker Nancy , Tropsha Alexander 
Published: September 2023

AbstractCOVID-19 vaccines have been instrumental tools in the fight against SARS-CoV-2 helping to reduce disease severity and mortality. At the same time, just like any other therapeutic, COVID-19 vaccines were associated with adverse events. Women have reported menstrual cycle irregularity after receiving COVID-19 vaccines, and this led to renewed fears concerning COVID-19 vaccines and their effects on fertility. Herein we devised an informatics workflow to explore the causal drivers of menstrual cycle irregularity in response to vaccination with mRNA COVID-19 vaccine BNT162b2. Our methods relied on gene expression analysis in response to vaccination, followed by network biology analysis to derive testable hypotheses regarding the causal links between BNT162b2 and menstrual cycle irregularity. Five high-confidence transcription factors were identified as causal drivers of BNT162b2-induced menstrual irregularity, namely: IRF1, STAT1, RelA (p65 NF-kB subunit), STAT2 and IRF3. Furthermore, some biomarkers of menstrual irregularity, including TNF, IL6R, IL6ST, LIF, BIRC3, FGF2, ARHGDIB, RPS3, RHOU, MIF, were identified as topological genes and predicted as causal drivers of menstrual irregularity. Our network-based mechanism reconstruction results indicated that BNT162b2 exerted biological effects similar to those resulting from prolactin signaling. However, these effects were short-lived and didn’t raise concerns about long-term infertility issues. This approach can be applied to interrogate the functional links between drugs/vaccines and other side effects.
The effects of gas flaring as moderated by government quality in leading natural gas flaring economies
Authors: Alola Andrew Adewale , Onifade Stephen Taiwo , Magazzino Cosimo , Obekpa Hephzibah Onyeje 
Published: September 2023

AbstractThis study seeks to address pertinent economic and environmental issues associated with natural gas flaring, especially for the world's leading natural gas flaring economies (i.e. Russia, Iraq, Iran, the United States, Algeria, Venezuela, and Nigeria). By applying relevant empirical panel and country-specific approaches, the study found that fuel energy export positively impacts economic growth with elasticity of ~ 0.22 to ~ 0.24 for the panel examination. It is further revealed that environmental quality in the panel is hampered by increase in economic growth, gas flaring, fuel energy export, and urbanization. Moreover, for the country-wise inference, government quality desirably moderates economic and environmental aspects of gas flaring in Venezuela and Nigeria, and in Russia and Iran respectively. However, government quality moderates gas flaring to cause economic downturn in the USA. Additionally, economic growth increased with increase in urbanisation (in Iraq and the USA), gas flaring (in Iran and the USA), government quality (only in the USA), and fuel energy export (only in Algeria) while economic growth downturn is due to increase urbanisation in Russia and the USA, increase in fuel energy export in the USA, and increase in government quality in Russia. Meanwhile, environmental quality is worsened through intense carbon dioxide emission from increased urbanisation activity (in Iraq, Iran, Algeria, and Nigeria), increased fuel energy export (in Nigeria), increased natural gas flaring (in Algeria and Nigeria), increased GDP (in Russia, Iran, USA, Algeria, and Venezuela), and high government quality (in Iran). Interestingly, the result revealed that increase in GDP (in Nigeria), increase in urbanisation (in the USA), and increase in gas flaring (in Algeria and Nigeria) dampens environmental quality. Importantly, this study offers policy insight into sustainable approaches in natural gas production, government effectiveness, and regulatory quality.