bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thinker, Gaoler, Soldier, and Spy: Sir John Peyton (1544–1630) and Early Modern Intelligence‐Brokering in the Tower of London
Authors: SHAW DANNIELLE 
Published: June 2023

AbstractThrough analysing local administrative records, state administrative records, and personal correspondence, this article demonstrates how Sir John Peyton's role as Lieutenant of the Tower of London (1597–1603) provides us with a hitherto unexamined opportunity for commissioning, extracting, brokering, and obtaining intelligence. In doing so, it makes the case for re‐examining the often‐overlooked contribution of Elizabethan and Jacobean administrators to the history of intelligence‐gathering in early modern England, here focussing on the position of the Lieutenant of the Tower of London.
Subsequent fertility, pregnancy, and gynaecological and psychological outcomes after maternal–fetal surgery for open spina bifida: A prospective cohort study
Authors: Haenen Kobe , Vergote Simen , Kunpalin Yada , De Catte Luc , Devlieger Roland , Lewi Liesbeth , van der Merwe Johannes , Russo Francesca , De Vloo Philippe , Lannoo Lore , Deprest Jan 
Published: June 2023

AbstractObjectiveTo determine the medium‐term maternal impact of open fetal spina bifida repair.DesignProspective cohort study.SettingUniversity Hospitals Leuven, Belgium.PopulationMothers who had open maternal–fetal spina bifida repair between March 2012 and December 2021.MethodsA patient‐reported survey on subsequent fertility, pregnancy, and gynaecological and psychological outcomes.Main outcome measuresComplications during subsequent pregnancies, and gynaecological and psychological problems.ResultsSeventy‐two out of 100 invited women completed the questionnaire (72%). Despite being advised not to, seven of 13 women attempting to conceive became pregnant within 2 years after fetal surgery and one woman delivered vaginally. Two of the 16 subsequent pregnancies were complicated by an open neural tube defect. One pregnancy was complicated by a placenta accreta and one pregnancy was complicated by a uterine rupture, both with good neonatal outcomes. Nearly half of respondents who did not attempt to conceive reported that this was because of their experience of the index pregnancy and caring for the index child. Three out of four respondents reported medium‐term psychological problems, mostly anxiety for the health of the index child, fear for recurrence in subsequent pregnancies and feelings of guilt.ConclusionsOpen maternal–fetal surgery for spina bifida did not appear to affect fertility in our cohort. Half of the attempts to conceive took place within 2 years. One uterine rupture and one placenta accreta occurred in 16 subsequent pregnancies. Most respondents reported psychological problems linked to the index pregnancy, which reinforces the need for long‐term psychological support.
Collecting touch DNA from glass surfaces using different sampling solutions and volumes: Immediate and storage effects on genetic STR analysis
Authors: Schulte Janine , Rittiner Nicole , Seiberle Ilona , Kron Sarah , Schulz Iris 
Published: June 2023

AbstractTouch DNA has become increasingly important evidence in todays' forensic casework. However, due to its invisible nature and typically minute amounts of DNA, the collection of biological material from touched objects remains a particular challenge that underscores the importance of the best collection methods for maximum recovery efficiency. So far, swabs moistened with water are often utilized in forensic crime scene investigations for touch DNA sampling, even though an aqueous solution provokes osmosis, endangering the cell's integrity. The aim of the research presented here was to systematically determine whether DNA recovery from touched glass items can be significantly increased by varying swabbing solutions and volumes compared with water‐moistened swabs and dry swabbing. A second objective was to investigate the possible effects of storage of swab solutions prior to genetic analysis on DNA yield and profile quality when stored for 3 and 12 months, as is often the case with crime scene samples. Overall, the results indicate that adapting volumes of the sampling solutions had no significant effect on DNA yield, while the detergent‐based solutions performed better than water and dry removal, with the SDS reagent yielding statistically significant results. Further, stored samples showed an increase in degradation indices for all solutions tested, but no deterioration in DNA content and profile quality, allowing for unrestricted processing of touch DNA samples stored for at least 12 months. One further finding was a strong intraindividual change in DNA amounts observed over the 23 deposition days which may be related to the donor's menstrual cycle.
Comparison of two data processing approaches for aroma marker identification in different distilled liquors using comprehensive two‐dimensional gas chromatography‐time‐of‐flight mass spectrometry dataset
Authors: Liu Zhipeng , Yang Kangzhuo , He Zhanglan , Zhao Dong , Zheng Jia , Qian Michael C. 
Published: June 2023

AbstractWhisky, brandy, rum, and Chinese baijiu are popular distilled spirits globally, and the volatile components play an essential role in the aroma of these distilled liquors. Volatile compounds in whisky, brandy, rum, and three main aroma types of Chinese baijiu (strong, light, and sauce) were investigated using comprehensive two‐dimensional gas chromatography‐time‐of‐flight mass spectrometry (GC×GC–TOFMS). Two significant variable detection approaches, the variable importance in the projection (VIP) and nonparametric test (Mann–Whitney U test), were compared to determine the volatile markers among these samples. It was found that the VIP model was more efficient in screening significant variants than the U test. A total of 117 common markers were selected by both the VIP and U test methods with potential aroma contributions. Esters and acids were the main aroma markers for baijiu, diethyl esters were the main aroma markers for brandy, whereras pyrazines, lactones, and furans were the main aroma markers for whisky. Based on the chosen markers, different unknown distilled liquors were successfully classified in the model validation. This study provided a feasible methodology for spirit sample speculation based on volatile composition obtained by GC×GC‐TOFMS.
Effects of vacuum microwave combined with freeze‐drying on the physicochemical properties, phenolic compounds, and antioxidant capacity of pear fruit slices
Authors: Zhang Huizhe , Zheng Wenxiu , Yan Ling , Liu Wei , Yao Fei , Liu Changhong , Zheng Lei 
Published: June 2023

AbstractThe effects of freeze‐drying (FD), vacuum microwave drying after freeze‐drying (FD‐VMD), and freeze‐drying after vacuum microwave drying (VMD‐FD) on the physicochemical properties, phenolic compounds, and antioxidant capacity of pear fruit slices were investigated. The results showed that FD samples had the highest crispness value (116.30 N·sec) and the lowest volume shrinkage ratio value (5.48%). Compared to FD, the VMD‐FD and FD‐VMD methods could save drying time without affecting the color of dried samples. FD‐VMD samples had the lowest rehydration capacity and maintained a homogeneous porous structure, while the VMD‐FD samples had obvious collapse. Compared to VMD‐FD samples, FD‐VMD samples had higher contents of ascorbic acid (20.91 mg/100 g), total phenolic (7.62 mg/g), total anthocyanin (0.21 mg/g), and gallic acid (1.21 µg/g). Moreover, FD‐VMD samples showed the highest antioxidant capacity as evaluated by the 2,2‐diphenyl‐1‐(2,4,6‐trinitrophenyl) hydrazyl scavenging activity, 2,2ʹ‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) scavenging capacity, and H2O2 content. Compared with FD and VMD‐FD, FD‐VMD was most effective in maintaining better quality and shortening drying time of pear fruit slices. These findings suggested that FD‐VMD might be a promising drying technique in the fruits and vegetable processing industries.
Evaluating estrogenic activity of isoflavones inmisousing yeast two‐hybrid method
Authors: Higa Yuuki , Nagano Rika , Kanauchi Makoto 
Published: June 2023

AbstractEstrogenic activity inmisowas evaluated without in vivo animal experimentation using in vitro method with yeast in a two‐hybrid method because of its similarities with human cells. First, the recombinant yeast containing genes of human estrogen receptor (hER) was prepared for modeling human cells. Subsequently, standard solutions of 17β‐estradiol and isoflavone (1.0 × 10−12– 1.0 × 10−6) were assayed using the yeast. Their yeast produces β‐glucosidase according to the concentrations of their solutions. Therefore, the estrogenic activity can be evaluated using recombinant yeast for the yeast two‐hybrid method. Results show that 17β‐estradiol has affinity to bind with Y187‐αα. Genistein has affinity to bind with Y187‐ββ. Daidzein, genistein, and glycitein inmisowere 2.0–2.2 times the average concentrations ofmiso. Particularly,Mame misohad the highest concentration of isoflavones among allmisosamples. Isoflavone inmisosamples showed estrogenic activity against Y187‐ββ.Mame misohad particularly high activity (1.97 U/OD6601.0) against Y187‐ββ modeling hERββ. Finally, the interaction of the human estrogen receptors was analyzed with 17β‐estradiol and isoflavones using Y187 strains. Isoflavone inhibited the estrogenic activity of 17β‐estradiol using Y187‐αα. However, the estrogenic activity of 17β‐estradiol against Y187‐αβ and Y187‐ββ, which model hER‐αβ and hER‐ββ, was activated by isoflavone. Results showed genistein as the antagonist of estrogenic activity within 17β‐estradiol against hERαα. However, it is an agonist of the activity within 17β‐estradiol against hERαβ and hERββ. The yeast two‐hybrid method has some potential for assessing the estrogenic activity of isoflavone in foods as a human model.Practical ApplicationToday, isoflavones in foods must be evaluated using in vivo methods such as animal experimentation because the estrogenic activities of isoflavones are agonist or antagonist with 17β‐estradiol against estrogen receptors. Because animal experimentation is time‐consuming and expensive, isoflavones in foods can be evaluated using yeast, a eukaryote that has similarity to human cells, while obviating in vivo methods. The yeast two‐hybrid method is useful to assay the estrogenic activity of isoflavones in foods.
Superoxide Dismutase Plays an Important Role in Maize Resistance to Soil CO2 Stress
Authors: XUE Lu , MA Junjie , HU Qian , MA Jinfeng 
Published: June 2023

AbstractCO2 capture and storage (CCS) has the risk of CO2 leakage, and this leakage always increases soil CO2 concentration, and the long‐term CO2 stress damages crop production in farmland. Using maize, the growth characteristics, such as plant height and yield, and physiological indexes (osmoregulation substances and antioxidant enzymes) were explored under different simulative CO2 leakage conditions. Further, the relationship between maize physiological indexes and soil CO2 concentration was analyzed, showing that soil CO2 stress inhibited maize growth to a certain extent, resulting in shorter plants, thinner stems and lower kernel yield. With an increase in soil CO2 concentration, the contents of malondialdehyde, soluble sugar and soluble protein in maize leaves increased; with continuing stress, the increase rate of malondialdehyde was greatly augmented, whereas the increase rates of soluble sugar and soluble protein decreased. With extended CO2 stress, the activity of the enzyme superoxide dismutase (SOD) increased continuously, while the activities of catalase and peroxidase first increased and then decreased. Superoxide dismutase activity was closely correlated with soil CO2 concentration (r = 0.762), and responded quickly to the change of soil CO2 concentration (R2 = 0.9951). Therefore, SOD plays an important role in maize resistance to soil CO2 stress. This study will help further understanding of the mechanism of maize tolerance to soil CO2 stress, providing a theoretical basis for agricultural production in CCS project areas.
Circ_0010235 confers cisplatin resistance in lung cancer by upregulating E2F7 through absorbing miR‐379‐5p
Authors: Wang Lifei , Wang Dongchang , Xu Zhen , Qiu Yali , Chen Gang , Tan Furong 
Published: June 2023

AbstractBackgroundCisplatin (DDP) treatment is one of the most predominant chemotherapeutic strategies for lung cancer patients. Circular RNAs (circRNAs) have been revealed to participate in the chemoresistance in lung cancer. Hence, the role and mechanism of circ_0010235 in cisplatin resistance in lung cancer was investigated.MethodsExpression levels of circ_0010235, microRNA (miR)‐379‐5p and E2F transcription factor 7 (E2F7) were analyzed using quantitative reverse transcription PCR (qRT‐PCR) and western blot. Cell DDP sensitivity, proliferation, apoptosis, invasion, and migration were detected by cell counting kit‐8 assay, 5‐ethynyl‐2′‐deoxyuridine (EDU) assay, flow cytometry and western blot, respectively. The binding interaction was verified using dual‐luciferase reporter assay. A murine xenograft model was established to investigate effects in vivo.ResultsCirc_0010235 was highly expressed in DDP‐resistant lung cancer tissues and cells. Knockdown of circ_0010235 elevated DDP sensitivity, constrained proliferation, invasion and migration as well as fostered apoptosis in DDP‐resistant lung cancer cells. Moreover, circ_0010235 silencing boosted DDP sensitivity and impeded tumor growth in lung cancer in vivo. Mechanistically, circ_0010235 acted as a sponge for miR‐379‐5p to elevate the expression of its target E2F7. Rescue experiments showed that miR‐379‐5p inhibition attenuated circ_0010235 knockdown‐evoked reduction on DDP resistance of DDP‐resistant cancer cells. In addition, miR‐379‐5p re‐expression elevated DDP sensitivity and suppressed the malignant phenotype of DDP‐resistant lung cancer cells through miR‐379‐5p.ConclusionCirc_0010235 knockdown reduced DDP resistance and tumor growth via miR‐379‐5p/ E2F7 axis in lung cancer, suggesting an effective therapeutic target for lung cancer patients.
Association of limited English proficiency with emergency department irregular departures and return visits: A cross‐sectional cohort study in the Upper Midwest between January 2018 and December 2021
Authors: Bower Sarah M. , Campbell Ronna L. , Mullan Aidan F. , Heaton Heather A. , Lim Thomas G. , Bellamkonda Venkatesh R. , Lichen Isabella M. , Jones Derick D. 
Published: June 2023

AbstractObjectivesPatients with limited English proficiency (LEP) have been shown to experience disparities in emergency department (ED) care. The objectives of this study were to examine the associations between LEP and irregular ED departures and return ED visits.MethodsWe conducted a multicenter cross‐sectional analysis of 18 EDs within an integrated health system in the upper Midwest from January 1, 2018, to December 31, 2021. ED visits of pediatric and adult patients who were discharged on the index visit were included for analysis. We analyzed the association of LEP with irregular departures, 72‐h and 7‐day return visits, and ED disposition at the time of that return visit. Multivariable model associations were calculated using generalized estimating equations and reported as odds ratios (OR) with 95% confidence intervals (CIs).ResultsA total of 745,464 total ED visits were analyzed, including 27,906 (3.7%) visits among patients with LEP. The most common preferred languages among patients with LEP were Spanish (12,759; 45.7%), Somali (4978; 17.8%), and Arabic (3185; 11.4%). After multivariable adjustment there were no differences in proportions of irregular departures (OR 1.09, 95% CI 0.99–1.21), 72‐h returns (OR 0.99, 95% CI 0.92–1.06), or 7‐day returns (OR 0.99, 95% CI 0.93–1.05) between patients with LEP or English proficiency. Patients with LEP returning within 72 h (OR 1.19, 95% CI 1.01–1.40) and 7 days (OR 1.15, 95% CI 1.01–1.33) were more likely to be admitted to the hospital.ConclusionsAfter multivariable adjustment, we did not find an increased frequency of irregular ED departures or 72‐h or 7‐day returns among patients with LEP compared with people proficient in English. However, we did find that higher proportions of patients with LEP were admitted to the hospital at the time of the return ED visit.
Individualism–collectivism and organ donation intentions
Authors: Li Jianbiao , Zang Ruqian , Niu Xiaofei 
Published: June 2023

AbstractThis article investigates the impact of individualism–collectivism on a person's willingness to donate organs. In Study 1, an online survey showed that individualism–collectivism was significantly and positively associated with participants' willingness to register as organ donors while perceived benefit mediated this relationship. Study 2 demonstrated the causal effect of individualism–collectivism on organ donation intentions using a priming technique. Participants primed with collectivism were more likely to register as organ donors than those primed with individualism. Our findings provide unique insights into whether cultural values (i.e., individualism–collectivism) can predict people's organ donation intentions.
In their footsteps
Authors: Falcone Jessica Marie 
Published: June 2023

SummaryA flash ethnography piece set at an Obon event in Hawai'i, “In Their Footsteps,” shows the way the author deploys dance as a method. By asking the reader to follow her through a day of fieldwork at a Soto Buddhist temple, the piece demonstrates how the anthropologist learns about the culture by absorbing and matching the movements of her interlocutors, both when they are dancing and when they are not.
A Prescriptive Framework for the Effective Deployment of Dynamic Capabilities
Authors: Hillner Matthias 
Published: June 2023

As market environments in areas such as information and communication technologies, social media, online retail and services, and music and gaming are becoming less predictable and more prone to disruption, dynamic capabilities are widely perceived as increasingly significant.Taking a new design to market is a risky and unpredictable endeavor—examining it in a new framework to systematically guide the process can help reduce the rate of failure.
Improving the accuracy and speed of fast template‐matching algorithms by neural architecture search
Authors: Shariatzadeh Seyed Mahdi , Fathy Mahmood , Berangi Reza 
Published: June 2023

AbstractNeural architecture search can be used to find convolutional neural architectures that are precise and robust while enjoying enough speed for industrial image processing applications. In this paper, our goal is to achieve optimal convolutional neural networks (CNNs) for multiple‐templates matching for applications such as licence plates detection (LPD). We perform an iterative local neural architecture search for the models with minimum validation error as well as low computational cost from our search space of about 32 billion models. We describe the findings of the experience and discuss the specifications of the final optimal architectures. About 20‐times error reduction and 6‐times computational complexity reduction is achieved over our engineered neural architecture after about 500 neural architecture evaluation (in about 10 h). The typical speed of our final model is comparable to classic template matching algorithms while performing more robust and multiple‐template matching with different scales.
Juntos hacemos la diferencia [together we make the difference]: A network analysis of Latinx caregivers' use of youth support services
Authors: Vázquez Alejandro L. , Chou Tommy , Helseth Sarah A. , Gudiño Omar G. , Domenech Rodríguez Melanie M. 
Published: June 2023

AbstractLatinx families face unique barriers to accessing traditional youth mental health services and may instead rely on a wide range of supports to meet youth emotional or behavioral concerns. Previous studies have typically focused on patterns of utilization for discrete services, classified by setting, specialization, or level of care (e.g., specialty outpatient, inpatient, informal supports), yet little is known about how youth support services might be accessed in tandem. This analysis used data from the Pathways to Latinx Mental Health study – a national sample of Latinx caregivers (N = 598) from across the United States collected at the start of the coronavirus pandemic (i.e., May–June 2020) – to describe the broad network of available supports that are used by Latinx caregivers. Using exploratory network analysis, we found that the use of youth psychological counseling, telepsychology, and online support groups was highly influential on support service utilization in the broader network. Specifically, Latinx caregivers who used one or more of these services for their child were more likely to report utilizing other related sources of support. We also identified five support clusters within the larger network that were interconnected through specific sources of support (i.e., outpatient counseling, crisis, religious, informal, and non‐specialty). Findings offer a foundational look at the complex system of youth supports available to Latinx caregivers, highlighting areas for future study, opportunities to advance the implementation of evidence‐based interventions, and channels through which to disseminate information about available services.
The development and pilot testing of a family treatment court best practices assessment: The model standards implementation scale
Authors: Lloyd Sieger Margaret H. , Becker Jessica , Earles Kelly , Thompson‐Wise Karin , Hagain Kaitlin 
Published: June 2023

AbstractIn 2019, the family treatment court (FTC) best practice standards (the Standards) were published to clarify attributes of FTC programs associated with superior child, parent, and family outcomes. The Standards cover the breadth of FTC operations including program structure and leadership, substance use treatment and complementary services, and behavioral responses to participants. This study aimed to develop an instrument (the Model Standards Implementation Scale; “MSIS”) that stakeholders can use to assess implementation of the Standards by individual FTCs. The MSIS balances usability with scientific validity. Interrater reliability (IRR), internal consistency, and several types of validity were assessed. Results indicated moderate to strong IRR, high internal consistency, mixed known groups validity depending on Standard, and high convergent and divergent validity. Initial findings suggest good validity and usability of the MSIS for evaluating FTC Standards' implementation. Notably, the process of using the tool functioned to educate FTC team members on the Standards. Although implementation of the MSIS is a resource‐intensive process, the opportunity to receive constructive feedback proved to be an effective incentive for initial and subsequent participation in the evaluation among FTCs. Future research is needed to examine predictive validity, including association between Standards' implementation and family outcomes in FTCs.