bluuebunny/crossref_metadata_2025_split huggingface dataset:
Åfficacy of nutraceutical drug in the intermediate and wet forms of age-related macular degeneration
Authors: Eskina E. N. , Belogurova A. V. , Gvetadze A. A. , Smorchkova A. S. 
Published: July 2023

The effectiveness of nutraceutical drug containing oxycarotenoids, vitamins and trace elements, aimed at inhibiting the progression of the dry form of age-related macular degeneration (AMD) has been demonstrated in clinical studies.The purpose of this research is to evaluate the effectiveness of long-term use of a nutraceutical drug in reducing the risk of intermediate AMD evolving into wet AMD, and assess whether it is worth using in patients with wet AMD to reduce the average yearly number of intravitreal injections of angiogenesis inhibitors.Materials and methods. In the first part of the study, we monitored 46 patients with intermediate AMD threatening the progression of the disease (those with multiple confluent drusen, drusenoid, pigment epithelium detachment) for a year: some of them received the drug while others had no nutraceutical support. We assessed standard visual functions, as well as reading parameters (on the Salzburg Reading Desk device), spatial frequency contrast sensitivity (SFC) according to the Zebra program, and macular pigment optical density (on the MPOD device). Retina parameters were controlled by photofixation using Kowa and Clarus 500 fundus camera, and by optical coherence tomography with angiography using a Cirrus 5000 Angioplex, Carl Zeiss. The disease was considered to be progressing if signs of neovascular AMD were detected. In the second part of the study, 35 patients with newly diagnosed neovascular AMD were followed up for a year and treated with angiogenesis inhibitors according to the following pattern: three loading injections of aflibercept and then pro re nata. Of two groups of patients with signs of neovascular AMD, one group took a nutraceutical drug (Lutrin, S.C. Rompharm Company S.R.L., Romania). The number of intravitreal injections of aflibercept administered according to indications during the year was estimated.Results. In the first part of the study, patients with intermediate AMD taking the drug showed an increase in MPOD from 0.36 ± 0.11 to 0.45 ± 0.15 (p = 0.05) and a stable state of the retina and visual functions throughout the entire observation period. In 2 patients (12.5 %) who did not take the drug, the disease progressed to a neovascular form. In the second part of the study, the patients taking the drug received an average of 3.4 ± 0.7 intravitreal injections of aflibercept during the year, compared with 5.3 ± 1.2 injections in the control group without nutraceutical support.Conclusion. Nutraceutical drugs are effective in reducing the risk of intermediate AMD evolving into wet AMD, and thus advisable for patients with wet AMD to reduce the average yearly number of intravitreal injections of angiogenesis inhibitors.
Flood hazards under changing climate: applying an analytical hierarchy process in the Mazam-Watrak River Basin, India
Authors: Makhasana Payal , Joshi Geeta S. 
Published: July 2023

AbstractIn this study, the coupling of the analytical hierarchy process (AHP) and geographical information system (GIS) was used to assess flood hazards. Spatial analysis in the GIS environment has been applied for the estimation of flood hazard zones in which five relevant physical factors have been selected, namely rainfall amount, slope, elevation, drainage density, and land use. The factors of rainfall amount and land use are subjected to changes over a time horizon. An attempt is made in this study to delineate the flood hazard zones under changing climate, i.e., delineating flood hazard zones in base and climate change scenarios. The proposed method is applied to the Mazam-Watrak River basin in the state of Gujarat, India for the data span 1961–2016. It is concluded that flood hazard zones proliferate in the downstream and eastern middle reaches of the basin and in a very high to high category in climate change scenarios. The results obtained from the AHP have been validated through the observed flood susceptible area in the basin.
Features of the functioning of B-2 lymphocytes in patients with common variable immune deficiency in post-vaccination immunity to SARS-CoV-2
Authors: Sizyakina L. P. , Andreeva I. I. , Kharitonova M. V. 
Published: July 2023

Objective: B-2 lymphocytes characteristic of patients with CVID in the process of forming a post-vaccination response to the peptide vaccine against SARS-CoV-2. Materials and methods: 10 people with CVID diagnosis were included in the study among a cohort of patients with primary immunodeficiency under the supervision of the Research Institute and the Department of Clinical Immunology and allergology of Rostov State Medical University. For the immunoprophylaxis of COVID-19, a recombinant peptide vaccine was used, which was administered intramuscularly at a dose of 0.5 ml twice with an interval of 21 days. The parameters of the immune system were evaluated before vaccination, then 21 days after the first and second doses and 72 days after the first injection. Phenotypic characteristic of peripheral blood B cells was performed by cytofluoriometry flow method. Results: before vaccination, the number of memory B cells with a phenotypic option of switched and unswitched to antibody synthesis at the patients with CVID was lower than the control parameters of practically healthy donors. 21 days after the administration of the first dose, an increase in un-switched and switched memory B cells, plasma blasts, and a decrease in the proportion of B-regulatory lymphocytes were noted in relation to the initial values. 21 days after the second injection, an increase in the total pool of B-2 lymphocytes, naive B cells, switched memory B cells, plasma blasts were revealed. A month later, this tendency continued. Conclusion: in the process of forming a post-vaccination response to the peptide vaccine against SARS-CoV-2 in patients with CVID, a transformation of the subpopulation composition of B lymphocytes was revealed, as well as in the form of an increase in the number of memory B2 lymphocytes.
The role of morphofunctional complexes and somnological signs of the pathogenesis of gestational diabetes mellitus in overweight women
Authors: Botasheva T. L. , Deriglazova O. I. , Lebedenko E. Yu. , Zheleznyakova E. V. , Zavodnov O. P. , Zheltetskaya V. Yu. , Ulkina A. A. 
Published: July 2023

Objective: to identify the diabetogenic type of the lateral behavioral profile of asymmetries, which reveals the highest incidence of GDM and obstetric complications in overweight pregnant women and, on its basis, to study the features of the somnological status in women with diabetogenic lateral constitution at the preconception period. Materials and methods: the study used special testing (Annette test, sleep quality questionnaire, sleep apnea/hypopnea syndrome questionnaire, sleepiness scale (Epworth)), polysomnographic study. Results: based on the results of a questionnaire survey and a polysomnographic study, somnological disorders were identified, expressed in a decrease in the efficiency and quality of sleep, fatigue, perceptible drowsiness in wakefulness, breathing disorders during sleep and other sleep disorders, which contributes to an increased risk of gestational diabetes mellitus mainly in women with an ambidextral lateral phenotype. Conclusion: the identified sleep disorders in overweight women in the pregravid period are, on the one hand, the result of hormonal changes against the background of already existing metabolic and vegetative abnormalities in overweight women planning pregnancy, on the other hand, they act as a “trigger” functional disorders both during the manifestation of GDM and during the formation of obstetric complications due to increasing hypoxemia in the maternal body against the background of the “obstructive sleep apnea” syndrome, which contributes to the development of fetal distress.
Comparative assessment of the relationship between mental health and insomnia of medical students, working and non-working as nurses
Authors: Samrkhanova I. I. , Kadyrov R. F. , Efremov I. S. , Abdrakhmanova A. E. , Asadullin A. R. 
Published: July 2023

Objective: to compare the severity of the relationship between mental state and insomnia of medical students working and not working as nurses. Materials and methods: research methods — sociological, psychometric, statistical. The study was conducted at the Bashkir State Medical University (BSMU) from February to April 2022. Data collection was carried out using Google Forms. Study group №1 — 172 students working as nurses. The proportion of males is 41 % (70/172), females — 59 % (102/172). The average age was 21-23 years. Study group № 1 — 66 non-working students. Among the studied 16.7 % (11/66) men, 83.3 % (55/66) women. The average age is 21-23 years. SCL-90-R (Symptom Check List-90-Revised), Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI) were used as methods. Statistical processing was carried out using Microsoft Excel, STATISTICA 10, Spearman correlation coefficient, U — Mann-whitney test. Results: the degree of manifestation of insomnia in the study group № 1 and № 2 positively correlates with both all SCL-90-R scales and second-order indices. when comparing the studied groups, it was found that the mental state of non-working students is more unstable, the quality of sleep is worse. Conclusions: the relationship between the mental state and insomniac disorders in medical students, both working as nurses and not working, has been established. we assume that students who do not work as nurses have low adaptive abilities, as a result of which their mental state is accompanied by more pronounced insomniac disorders.
Clinical and biochemical phenotypes in cardiorespiratory comorbidity
Authors: Prokofyeva T. V. , Bashkina O. A. , Polunina O. S. , Sevostyanova I. V. , Gritsenko E. L. 
Published: July 2023

Objective: to estimate the incidence of recurrent myocardial infarction, stroke, and mortality in patients with different phenotypes of myocardial infarction against the background of chronic obstructive pulmonary disease. Materials and methods: 325 patients with myocardial infarction were examined: 195 patients with infarction against the background of chronic obstructive pulmonary disease and 130 patients without chronic obstructive pulmonary disease. We studied markers of endogenous intoxication: molecules of average mass, hematological indexes of intoxication, blood gas composition, apoptosis, protein peroxidation, lipid and antioxidant protection, inflammation and renal function. Statistical processing of the data was performed using SPSS 26.0 software package. Results: A two-stage cluster analysis formed four clusters, which were labeled as «polymarker-retentive», «necrotic-inflammatory», «hypoxic-inflammatory», and a cluster with no endogenous intoxication syndrome. Among patients with myocardial infarction against the background of chronic obstructive pulmonary disease, the hypoxic-inflammatory phenotype prevailed — in 53.3 % of patients. Necrotic-inflammatory phenotype was noted in 8.2 % of patients, hypoxic-inflammatory — in 36.9% of patients, phenotype with the absence of endogenous intoxication syndrome — in 1.5 % of patients. Recurrent myocardial infarction, stroke and mortality constituted the combined endpoint. The highest incidence of the combined endpoint was observed in the polymarker-retentive infarct phenotype — in 37 (55.2 %) patients. Conclusion: Vascular life-threatening and fatal events (recurrent myocardial infarction, stroke, death from cardiac causes) during 12-month follow-up are most typical for the polymarker-retentive phenotype. The clinical features of this phenotype were the frequent presence of Q-shaped MI, transmural myocardial damage, and the presence of complications in the acute period. COPD in these patients was characterized by a long course, high smoker's index, mostly 3rd degree bronchoobstruction, and frequent exacerbations. The results of this study allow for a personalized approach to the assessment of the annual prognosis in patients with acute myocardial infarction against COPD.
The Use of Virtual Reality Interventions to Promote Positive Mental Health: Systematic Literature Review
Authors: Li Pira Giorgio , Aquilini Beatrice , Davoli Alessandro , Grandi Silvana , Ruini Chiara 
Published: July 2023

Background
A large body of research has documented the efficacy of psychological interventions integrated with virtual reality (VR) therapies in treating psychiatric disorders. However, the concept of positive mental health calls for a 2-fold approach in which both symptoms and positive functioning should be addressed by modern interventions.

Objective
This review aimed to summarize studies that applied VR therapies by embracing the positive mental health perspective.

Methods
A literature search was conducted by entering the following keywords—“virtual reality” AND “intervention” OR “treatment” OR “therapy” AND “mental health” NOT “systematic review or meta-analysis”—and limiting it to “journal article” and the English language. To be included in this review, articles had to present at least one quantitative measure of positive functioning and one quantitative measure of symptoms or distress and had to investigate adult populations, including populations with psychiatric disorders.

Results
A total of 20 articles were included. They described various VR protocols that were applied for the treatment of anxiety disorders (5/20, 25%), depression (2/20, 10%), posttraumatic stress disorder (3/20, 15%), psychosis (3/20, 15%), and stress (7/20, 35%). Most of the studies (13/20, 65%) showed the beneficial effects of VR therapies in improving stress and negative symptoms. However, 35% (7/20) of the studies showed no or a small effect on the various dimensions of positivity, particularly in clinical samples.

Conclusions
VR interventions might be cost-effective and largely scalable, but further research is needed to develop existing VR software and treatments according to the modern positive mental health approach.
Global Market Reaction to the Indonesian Islamic Capital Market During Covid Outbreak
Authors: Habibi Ahmad , Normasyhuri Khavid , Ma'rifah Aula Nurul 
Published: July 2023

The COVID-19 pandemic has impacted the global Islamic capital market, including Indonesia. As a result, it is critical to investigate the global stock market reaction to this issue. This study seeks to comprehend the global Islamic stock market's reaction to the Indonesian Islamic stock market, as represented by the Jakarta Islamic Index (JII), during the COVID-19 outbreak. To test the hypothesis, this study employs the Error Correction Model (ECM) techniques. The findings revealed that the global Islamic stock market had a significant influence on the Indonesian Islamic stock market during that time, both in the short and long term. This is due to the Islamic stock market's interconnected nature, which attracts investors as it allows foreigners to own Islamic stocks in Indonesia, and also offers valuable long- and short-term prospects. In addition, the globalization of the world economy, social and political relations are interrelated between countries, especially in the era of COVID-19. Because the outbreak was unavoidable, it caused global economic chaos and extreme crises, including investments in the Islamic stock market. In light of crisis, the findings of this study can be used as practical guidance for investors considering investing in the Islamic stock market.============================================================================================================== ABSTRAK - Reaksi Pasar Global Terhadap Pasar Modal Syariah Indonesia Dalam Masa Covid-19. Pandemi COVID-19 berdampak pada pasar modal syariah global, termasuk Indonesia. Oleh karena itu, kajian yang berkaitan dengan hal tersebut sangat penting dilakukan. Penelitian ini bertujuan untuk mengkaji reaksi pasar modal syariah global terhadap pasar modal syariah Indonesia yang diwakili oleh Jakarta Islamic Index (JII) dalam masa COVID-19. Untuk menguji hipotesis, penelitian ini menggunakan teknik Error Correction Model (ECM). Hasil temuan menunjukkan bahwa pasar modal syariah global memiliki pengaruh signifikan terhadap pasar modal syariah Indonesia, baik dalam jangka pendek maupun jangka panjang. Hal ini disebabkan oleh sifat interkoneksi pasar modal syariah, yang menarik investor karena memungkinkan orang asing untuk memiliki saham syariah di Indonesia, dan juga menawarkan prospek jangka panjang dan jangka pendek yang menguntungkan. Selain itu, akibat globalisasi ekonomi, hubungan sosial dan politik antar negara saling berkaitan, terutama di era COVID-19. Karena pandemi tersebut tidak terhindarkan, kondisi ekonomi global dan krisis terjadi dalam berbagai sektor, termasuk pasar modal syariah. Temuan penelitian ini berimplikasi sebagai pedoman praktis bagi investor dalam berinvestasi di pasar modal syariah di Indonesia.
Cross-Cultural Understanding dan Deradikalisasi Agama: Studi Kasus Mahasiswa Pendidikan Bahasa Inggris IAIN Surakarta
Authors: Mulyono Tyas , Rifanan Arif , Muktiati Sarah , Annisa Dina Fitri , Yulianingsih Tri 
Published: July 2023

This article aims to determine the role of subjects Cross-Cultural Understanding in an effort de-radicalization among students majoring inÂ English and optimize it to protect students from the influence of radical Islam. The collection of data carried out by interviewing several CCU lecturers in Islamic Education and Teacher Training Faculty IAIN Surakarta and distributing questionnaires to English Education students using Google Drive. Interviews indicate that this course has a close relationship with efforts to de-radicalization of Islam. As the results of the questionnaire indicate that 69.8% of students answered strongly agree Cross-Cultural Understanding courses teach to tolerate as an effort to reduce radical movements, hereby this course can be used by English educators to contribute in efforts to the de-radicalization program.Keywords:Cross-cultural understanding, Islamic radicalism, De-radicalization
MODEL PENDAMPINGAN BELAJAR ORANG TUA UNTUK ANAK BERKEBUTUHAN KHUSUS SELAMA MASA PANDEMI
Authors: Rahmawati Tias , Fartiwi Fartiwi , Fatimah Umi Nur 
Published: July 2023

Education is a basic right for every citizen, including children with special needs who need guidanceÂ from people who are experts in their fields. During the pandemic, children wereÂ required to study at home with guidanceÂ from their parents. The purpose of this study was to find outÂ the model of parental learning guidanceÂ for children with special needs during the pandemic. This research uses a case study method and data collection using interviews with thematic analysis. From the results of the study, there are three models of parent learning guidance for children with special needs during the pandemic, namely learning guidanceÂ using permissive, authoritarian, and authoritative parenting approaches.Keywords:Â children whit special needs; guiding study; pandemic
PENGUKURAN ISLAMICITY PERFORMANCE INDEX (IPI) PADA KINERJA KEUANGAN BANK CENTRAL ASIA (BCA) SYARIAH PERIODE 2017-2021
Authors: Ayu Nurfallah Chandra , Nurtiasih Assyifa , Nur Diawati Suchehi , Ulfah Rufi Widya Janah Mirta , Sabita Putri Haura 
Published: July 2023

Assets of Islamic financial institutions always increase from year to year. One of those that experienced an increase was Bank Central Asia (BCA) Syariah which experienced an increase of 9.5% in 2021 from the previous year with a nominal figure of 10,642.3 billion. There is a lot of general discussion in the community that Islamic banks are not much different from conventional banks. Some even think they have the same principle. Thus, this research needs to be done to determine the compliance of Islamic principles in BCA Syariah. This measurement is carried out using the Islamicity Performance Index (IPI) proposed by Hameed (2004). The research was conducted using quantitative methods with a descriptive approach. The results showed that the PSR and IIC ratios had the predicate "quite satisfactory" and "very satisfactory." Meanwhile, the EDR ratio and zakat performance are inversely proportional to the "very unsatisfactory" predicate. The DEWR ratio shows a gap between directors and employees 21-29 times during 2017-2021. This research can contribute to all stakeholders in BCA Syariah.
Keywords: BCA Syariah; Islamicity Performance Index; Sharia financial performance.
ILMU KANTONG BOLONG R.M.P SOSROKARTONO DALAM PERSPEKTIF MORALITAS DAN IMPLEMENTASINYA PADA KEHIDUPAN MILENIAL
Authors: Thohari Ahmad Miftahudin , Faridatun Nisa Lia , Azizah Nur , Mutoharoh Rina , Aris Tantia Erdiana 
Published: July 2023

Ilmu Kantong Bolong was one of the ideas propounded by R.M.P sosrokartono. It is the teaching that gives understanding to man that in life all the material riches that a man has should not be kept in tight order, but should always be directed to his fellowmen who need them. Wealth does not belong to absolute humans but only to those in need. Through literature studies (library research), it has been produced that in a moral perspective the doctrine of Ilmu Kantong Bolong contained the doctrine of humanity. It is that people should help one another and give to one another. So in its implementation of life today, successive generations can apply that moral teaching so as not to choose to be selfish and individualistic only for themselves.
Keywords: Ilmu Kantong Bolong; Sosrokartono; Morality, Milenials Generation
Definitive Treatment of Open Pelvic Fractures with External Fixator
Authors: Ba Papa Amadou , Ba Abdoulaye , Djiba Cherif Sadibou , Dembélé Mamadou 
Published: July 2023

Background: Unstable and open pelvic fractures are often associated with significant morbidity and mortality, especially in patients with multiple injuries. Early pelvic fixation provides stability and should diminish ongoing hemorrhage. Materials and Methods: We undertook a retrospective and descriptive study of all cases of unstable open pelvic fractures treated with external fixators in the orthopedic and trauma surgery department of the Army Training Hospital Principal in Dakar over 4 years ranging from 1 January 2018 to 31 December 2022. Results: 12 patients were included in this study. The mean age of the patients was 39 years with extremes of 21 and 56 years. The series consisted of 10 men (83.3%) and 2 women (16.7%), representing a sex ratio of 5. The etiology of the open fractures was road traffic accidents (61%), followed by public road accidents (33%), and finally falls from a high place (6%). The injury mechanisms were direct impact in 9 cases and 3 cases of indirect impact by shearing. Bone injuries were Tile B in 75% and Tile C in 25%. Soft tissue lesions were located in the perineum in 7 patients, in the inguinal area in 2 patients, and the buttock in 1 patient. Pelvic exofixation was performed in all patients with an average delay of 12 hours, with extremes of 4 and 24 hours. One case of infection was observed in the medium-term outcome. Three deaths were recorded. Radiographically, the reduction was satisfactory in 75% of cases (N=9) (Figs. 6 and 7), tolerable in 16.7% (N=2), and poor in 8.3% (N=1). Two patients had a residual disjunction of more than 5mm. Conclusion: The external fixator in unstable open fractures of the pelvis appears to be a good alternative that finds its place within the limits of emergency internal osteosynthesis (hemodynamic instability, hemorrhagic and infectious risk). The limits of its use in isolation are related to its inefficiency in the reduction and correct stabilization of lesions of the posterior arch.