bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entwicklung eines Anforderungsprofils für Betriebliche Gesundheitsmanager:innen
Authors: Wedel Sebastian , Nöfer Eberhard , Schütz Astrid 
Published: January 2023

Zusammenfassung
Hintergrund
Die Aufgaben Betrieblicher Gesundheitsmanager:innen sind vielfältig. Für die zielgerichtete Personalauswahl und anforderungsgerechte Ausbildung im betrieblichen Gesundheitsmanagement (BGM) fehlt bislang aber ein entsprechendes Anforderungsprofil.

Ziel der Arbeit
Ziel dieser Arbeit war die Entwicklung eines Anforderungsprofils für Betriebliche Gesundheitsmanager:innen unter Einbeziehung von Subject Matter Experts.

Material und Methoden
Das Anforderungsprofil wurde mithilfe der Task Analysis Tools (TAToo) [6] erstellt. Das 3‑stufige Vorgehen umfasste 21 semistrukturierte Interviews mit Stelleninhaber:innen und Führungskräften, zwei Workshops sowie eine Online-Befragung (n = 46) zur ökologischen Validierung der Ergebnisse. Auf Grundlage dieser Informationen wurde ein Anforderungsprofil für Betriebliche Gesundheitsmanager:innen erstellt.

Ergebnisse
Die Aufgaben, Ziele und Schnittstellen von Betrieblichen Gesundheitsmanager:innen sind vielfältig. Fachwissen aus den Bereichen Gesundheitswissenschaften, Psychologie, Ergonomie, Arbeitswissenschaften und Betriebswirtschaftslehre sind für die Tätigkeit im BGM besonders wichtig. Aus dem Bereich der Methodenkompetenzen sind Netzwerkfähigkeit, systematisches Arbeiten, Präsentationsvermögen sowie Projektmanagement relevant. Als wichtige Soft-Skills gelten Vertrauenswürdigkeit, Leidenschaft für das Thema Gesundheit, Begeisterungsfähigkeit sowie Zuverlässigkeit und Teamfähigkeit. COVID-19 („coronavirus disease 2019“) scheint das Anforderungsprofil leicht verändert zu haben, sodass die Themen Digitalisierung, gesunde Führung, psychische Gesundheit, Gesundheit im Homeoffice und Pandemiemanagement an Bedeutung gewonnen haben.

Diskussion
Limitationen hinsichtlich der Verallgemeinerbarkeit des Anforderungsprofils können sich aus der mangelnden Repräsentativität der Stichprobe ergeben. Arbeitssicherheit, Arbeitsmedizin, betriebliches Eingliederungsmanagement (BEM), Evaluation und Digitalisierung sollten bei der Ausbildung von Betrieblichen Gesundheitsmanager:innen sowie bei der Personalauswahl eine größere Rolle als bislang spielen.
A comparison of total thoracoscopic versus robotic approach for cardiac myxoma resection: a single-center retrospective study
Authors: Liu Yanyi , Liu Zhuang , Li Xin , Jiang Yiyao , Lu Chenghao , Zhang Chengxin , Ge Shenglin 
Published: January 2023

AbstractAdvances in instrumentation and technique have facilitated minimally invasive surgeries for cardiac myxoma treatment. This study aims to compare the clinical outcomes between the thoracoscopic and robotic approaches for myxoma resection. Intraoperative data and postoperative data of 46 patients who underwent either thoracoscopic (n = 15) or robotic (n = 31) cardiac myxoma resection in our center between July 2013 and September 2022 were retrospectively compared. There was no in-hospital death in either group. Meanwhile, the operative time and cardiopulmonary bypass time were significantly shorter in the robotic group than in thoracoscopic group (P = 0.015 and P = 0.035, respectively). Furthermore, shorter ICU stays (P = 0.006), shorter postoperative mechanical ventilation time (P = 0.035) and less thoracic drainage (P = 0.040) were observed in the robotic group. However, the operating room costs and total hospital costs were both significantly lower in thoracoscopic group (P = 0.004 and P = 0.007, respectively). There was no significant difference between two groups regarding the incidence of postoperative complications (P > 0.05). Lastly, a faster return to exercise was noted in robotic group than in thoracoscopic group (Log-Rank χ2 = 4.094, P = 0.043). Both approaches can be safe and feasible for myxoma resection. However, regardless of higher expenses, the robotic myxoma resection approach provides shorter operation time, less postoperative thoracic drainage, and faster recovery than total thoracoscopic technique.
Confessions of a Green Notebook: Reading Unpublished Documents About the Oppression of Iranian Archaeology Professors During the 1980s
Authors: Papoli-Yazdi Leila 
Published: January 2023

AbstractA couple of months after the 1979 revolution of Iran, the universities were occupied by the Islamists who oppressed dissident academics drastically. Two years after the revolution, the headquarter of the Cultural Revolution was established, and universities were shuttered to be purified from any other ideology except Islamism. Due to the heavy censorship of the regime, very little is known about the documents and process of oppression during and after the occupation of the universities. In 2010, the author gained access to a ‘green notebook’ found in a trashcan at the University of Tehran, which contains informal minutes of several meetings held by the Islamic Association of Students (IAS). As a direct practice of oppression, IAS had the mission to report the behaviors of the professors working in the department of archaeology to authorities. In this article, the author elucidates the process of oppression of archaeology professors through reading documents of the ‘green notebook.’
The Effect of Species and Sex on the Element Content of Muskox (Ovibos moschatus) and Caribou (Rangifer tarandus groenlandicus) Tissues
Authors: Ribeiro David Miguel , Raundrup Katrine , Mourato Miguel P. , Almeida André M. 
Published: January 2023

Abstract
Muskox (Ovibos moschatus) and caribou (Rangifer tarandus groenlandicus) are wild ruminants that inhabit the Greenland tundra. They are part of the diet of many Greenlanders, being important sources of protein and micronutrients such as iron. The objective of this study is to analyse the element profiles of three tissues from these species: skeletal muscle, liver and adipose tissue, and to determine if they are affected by species and sex (male vs. female). Samples were obtained from annual hunts in two different regions of West Greenland. Element profiles were analysed using inductively-coupled plasma–optical emission spectrometry. The interaction between species and sex was only detected in Na (sodium) in the muscle and adipose tissue, where male and female caribou had the highest concentrations, respectively. The effect of sex was not statistically significant in the liver samples and only occasionally in the other tissues. Species was the most relevant factor in element profiles found in this study. Caribou had higher concentrations of K (potassium) and S (sulphur) in the muscle and liver. Fewer differences were detected between species in the adipose tissue, compared to the other tissues. These differences may reflect the feeding behaviour and the geographical location of both species. This study contributes to evaluate the element composition of the edible tissue of these wild ungulate species, as well as evaluating the factors of sex and species that could differentiate their composition.
Cancer Stem Cells are Actually Stem Cells with Disordered Differentiation: the Monophyletic Origin of Cancer
Authors: Luo Qiankun , Liu Pan , Yu Pengfei , Qin Tao 
Published: January 2023

AbstractCancer stem cells (CSCs) play an important role in cancer development. Based on advancements in CSC research, we propose a monophyletic model of cancer. This model is based on the idea that CSCs are stem cells with disordered differentiation whose original purpose was to repair damaged tissues. Inflammatory responses and damage repair signals are crucial for the creation and maintenance of CSCs. Normal quiescent stem cells are activated by environmental stimulation, such as an inflammatory response, and undergo cell division and differentiation. In the initial stage of cancer development, stem cell differentiation leads to heteromorphism due to the accumulation of gene mutations, resulting in the development of metaplasia or precancerosis. In the second stage, accumulated mutations induce poor differentiation and lead to cancer development. The monophyletic model illustrates the evolution, biological behavior, and hallmarks of CSCs, proposes a concise understanding of the origin of cancer, and may encourage a novel therapeutic approach.
Graphical Abstract
Polymorphic renal transporters and cisplatin’s toxicity in urinary bladder cancer patients: current perspectives and future directions
Authors: Selim Mohamed S. , Kassem Amira B. , El-Bassiouny Noha A. , Salahuddin Ahmad , Abu El-Ela Raghda Y. , Hamza Marwa Samir 
Published: January 2023

AbstractUrinary bladder cancer (UBC) holds a potentially profound social burden and affects over 573,278 new cases annually. The disease’s primary risk factors include occupational tobacco smoke exposure and inherited genetic susceptibility. Over the past 30 years, a number of treatment modalities have emerged, including cisplatin, a platinum molecule that has demonstrated effectiveness against UBC. Nevertheless, it has severe dose-limiting side effects, such as nephrotoxicity, among others. Since intracellular accumulation of platinum anticancer drugs is necessary for cytotoxicity, decreased uptake or enhanced efflux are the root causes of platinum resistance and response failure. Evidence suggests that genetic variations in any transporter involved in the entry or efflux of platinum drugs alter their kinetics and, to a significant extent, determine patients’ responses to them. This review aims to consolidate and describe the major transporters and their polymorphic variants in relation to cisplatin-induced toxicities and resistance in UBC patients. We concluded that the efflux transporters ABCB1, ABCC2, SLC25A21, ATP7A, and the uptake transporter OCT2, as well as the organic anion uptake transporters OAT1 and OAT2, are linked to cisplatin accumulation, toxicity, and resistance in urinary bladder cancer patients. While suppressing the CTR1 gene’s expression reduced cisplatin-induced nephrotoxicity and ototoxicity, inhibiting the expression of the MATE1 and MATE2-K genes has been shown to increase cisplatin’s nephrotoxicity and resistance. The roles of ABCC5, ABCA8, ABCC10, ABCB10, ABCG1, ATP7B, ABCG2, and mitochondrial SLC25A10 in platinum-receiving urinary bladder cancer patients should be the subject of further investigation.
Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and traumatic brain injury
Authors: PerezGrovas-Saltijeral Adriana , Rajkumar Anto P. , Knight Helen Miranda 
Published: January 2023

AbstractEpigenetic processes have become increasingly relevant in understanding disease-modifying mechanisms. 5-Methylcytosine methylations of DNA (5mC) and RNA (m5C) have functional transcriptional and RNA translational consequences and are tightly regulated by writer, reader and eraser effector proteins. To investigate the involvement of 5mC/5hmC and m5C effector proteins contributing to the development of dementia neuropathology, RNA sequencing data of 31 effector proteins across four brain regions was examined in 56 aged non-affected and 51 Alzheimer’s disease (AD) individuals obtained from the Aging, Dementia and Traumatic Brain Injury Study. Gene expression profiles were compared between AD and controls, between neuropathological Braak and CERAD scores and in individuals with a history of traumatic brain injury (TBI). We found an increase in the DNA methylation writers DNMT1, DNMT3A and DNMT3B messenger RNA (mRNA) and a decrease in the reader UHRF1 mRNA in AD samples across three brain regions whilst the DNA erasers GADD45B and AICDA showed changes in mRNA abundance within neuropathological load groupings. RNA methylation writers NSUN6 and NSUN7 showed significant expression differences with AD and, along with the reader ALYREF, differences in expression for neuropathologic ranking. A history of TBI was associated with a significant increase in the DNA readers ZBTB4 and MeCP2 (p < 0.05) and a decrease in NSUN6 (p < 0.001) mRNA. These findings implicate regulation of protein pathways disrupted in AD and TBI via multiple pre- and post-transcriptional mechanisms including potentially acting upon transfer RNAs, enhancer RNAs as well as nuclear-cytoplasmic shuttling and cytoplasmic translational control. The targeting of such processes provides new therapeutic avenues for neurodegenerative brain conditions.
Graphical abstract
DLT architectures for trust anchors in 6G
Authors: Krummacker Dennis , Veith Benedikt , Lindenschmitt Daniel , Schotten Hans D. 
Published: January 2023

AbstractThis manuscript investigates viable Distributed Ledger Technology (DLT) architecture approaches to be used as basis for the distribution of integrity verification data. We discuss what can be a Trust Anchor and how the property of trust can be enabled as a service for mobile communications infrastructures. This follows up on a preceding publication, in the course of which a service was developed that can be utilized to create trust and traceability in transactions between other services. Crucial for the integrity of such an audit trail is proof for which side was committing, in case a tampering was detected. For such verification in the aftermath, mechanisms for the distribution of meta data are necessary. Where our ultimate goal is to develop a versatile framework for Trust as a Service (TaaS), the work at hand contributes the investigation on header distribution. We put a major focus on providing Trust as a Service (TaaS) especially in the mobile communications domain since a reliable concept for trustworthiness is indispensable for the vision of organic infrastructures beyond 5G, which means that such networks are flexible regarding their composition and open for stakeholders.
The significance of Apis cerana cerana (Hymenoptera: Apidae) gnawing off the old brood cells
Authors: Meng Qingxin , Yang Shunhua , Huang Rong , Yang Linfu , Xun Lijie , Tian Yakai , Gong Xueyang , Wang Jianming , Kuang Haiou , Zhao Wenzheng , Dong Kun 
Published: January 2023

AbstractApis cerana cerana has the biological characteristic of gnawing off the old brood cells which reared multiple generations of workers. This study investigated the internal structure of newly built, old, and semi-rebuilt brood cells and their effects on the morphological development of workers to understand the significance of Apis cerana cerana gnawing off the old brood cells. The results showed that there was no significant difference among the three diameters (at the top, middle, and bottom positions) of newly built or semi-rebuilt brood cells (P > 0.05), but these changed within the old brood cells (P < 0.05). The top, middle, or bottom diameters of the newly built and semi-rebuilt brood cells were significantly larger than those of the old brood cells (P < 0.05), but were almost the same between the newly built and the semi-rebuilt brood cells (P > 0.05). The weight and base thickness of the cocoon were significantly greater in the old brood cells than those in the semi-rebuilt brood cells (P < 0.05). Importantly, the birth weight, body length, and the tested six external morphological indices did not show a significant difference between the newly built and semi-rebuilt brood cells (P > 0.05) but were significantly larger than those of old brood cells (P < 0.05). The size of the brood cell and the external morphology of the workers showed a positive correlation. This study highlights the significance of Apis cerana cerana gnawing off the old brood cells providing a reference for its scientific rearing.
Transition to legume-supported farming in Europe through redesigning cropping systems
Authors: Notz Inka , Topp Cairistiona F. E. , Schuler Johannes , Alves Sheila , Gallardo Leonardo Amthauer , Dauber Jens , Haase Thorsten , Hargreaves Paul R. , Hennessy Michael , Iantcheva Anelia , Jeanneret Philippe , Kay Sonja , Recknagel Jürgen , Rittler Leopold , Vasiljević Marjana , Watson Christine A. , Reckling Moritz 
Published: January 2023

AbstractLegume-supported cropping systems affect environmental, production, and economic impacts. In Europe, legume production is still marginal with grain legumes covering less than 3% of arable land. A transition towards legume-supported systems could contribute to a higher level of protein self-sufficiency and lower environmental impacts of agriculture. Suitable approaches for designing legume-supported cropping systems are required that go beyond the production of prescriptive solutions. We applied the DEED framework with scientists and advisors in 17 study areas in nine European countries, enabling us to describe, explain, explore, and redesign cropping systems. The results of 31 rotation comparisons showed that legume integration decreased N fertilizer use and nitrous oxide emissions (N2O) in more than 90% of the comparisons with reductions ranging from 6 to 142 kg N ha−1 and from 1 to 6 kg N2O ha−1, respectively. In over 75% of the 24 arable cropping system comparisons, rotations with legumes had lower nitrate leaching and higher protein yield per hectare. The assessment of above-ground biodiversity showed no considerable difference between crop rotations with and without legumes in most comparisons. Energy yields were lower in legume-supported systems in more than 90% of all comparisons. Feasibility and adaptation needs of legume systems were discussed in joint workshops and economic criteria were highlighted as particularly important, reflecting findings from the rotation comparisons in which 63% of the arable systems with legumes had lower standard gross margins. The DEED framework enabled us to keep close contact with the engaged research-farmer networks. Here, we demonstrate that redesigning legume-supported cropping systems through a process of close stakeholder interactions provides benefits compared to traditional methods and that a large-scale application in diverse study areas is feasible and needed to support the transition to legume-supported farming in Europe.
Assessing the Preliminary Efficacy of a Nonrandomized, Clinic-Based HIV Risk Reduction Pilot Intervention for PrEP-Initiated, Alcohol- and Other Drug-Using Women of Color in Miami, FL
Authors: Ichite Amanda , Jean-Gilles Michèle , Rosenberg Rhonda , Abbamonte John , Dévieux Jessy G. 
Published: January 2023

AbstractIn this paper, we assessed the preliminary efficacy and acceptability of a quasi-experimental, clinic-based sexual risk reduction pilot intervention for pre-exposure prophylaxis (PrEP)-initiated, alcohol- and other drug-using women of color and explored their self-reported barriers to, and facilitators of, PrEP use. Using a mixed methods design, analyses incorporated pre- and post-intervention study assessment data from 38 women and semi-structured process evaluations using a subsample of 25. The intervention administered over an 8-week period consisted of 4 one-on-one in person educational sessions, a process evaluation, and study assessments conducted at baseline and 3 and 6 months. Post intervention, statistically significant changes in sexual risk scores were not observed; however, we found significant decreases in alcohol use (Z =  − 3.02, p = .003, η2 = .41). Process evaluation data revealed interpersonal relationships as a key motivator for PrEP initiation as well as a prominent barrier to PrEP use; these relationships rarely facilitated adherence. Overall, women found the intervention to be acceptable and reported a wide range of benefits of participation—most notably its therapeutic benefits. Findings from this study provide preliminary evidence of the potential for the Talking PrEP with Women of Color intervention to improve risky behaviors, knowledge, and attitudes related to sexual risk taking. Furthermore, findings suggest that interventions to increase PrEP uptake and adherence in at-risk women may benefit from supporting them in accurately estimating their risk for HIV and increasing their sense of social support.
Exposure risk to carbon monoxide concentrations inside a diesel-based bus rapid transport system: a CFD-Monte Carlo modeling approach
Authors: Guevara-Luna Marco Andrés , Guevara-Luna Fredy Alejandro , Casallas Alejandro , Belalcázar-Cerón Luis Carlos 
Published: January 2023

AbstractBus rapid transit (BRT) vehicles are common microenvironments in urban areas. In some cities, these BRT vehicles are diesel-powered, which makes them highly pollutant. Recent studies report high levels and exposure risk to particulate matter in BRT vehicles. Nevertheless, extensive research has yet to be published, including gaseous pollutants (e.g., CO). Nevertheless, extensive research including gaseous pollutants (e.g., CO) has not been published. This research aims to evaluate the self-pollution of BRT buses in terms of exhaust gasses. For this, measurements and computational fluid dynamics (CFD) were used. Results suggest that pollutant concentrations stay low during most of the trips. However, some areas of the buses have significant swings and peaks due to the transit cycle. Here, we used CFD modeling to evaluate the dispersion of the exhaust CO inside and outside the bus. CFD results show that the bus rear has the highest concentrations, with a mean self-pollution ratio of 12%. Additionally, we developed a method based on the source-receptor relationship to quantify the impact of exhaust emissions reduction on self-pollution, showing that the technological replacement of current diesel buses would reduce self-pollution and, therefore, passenger exposure. Finally, since modeling results may be inaccurate, an uncertainty analysis was developed using the Monte Carlo method to obtain a confidence interval of 90% for the variables linked to the self-pollution.
Large-format additive manufacturing of polymer extrusion-based deposition systems: review and applications
Authors: Vicente Carlos M. S. , Sardinha Manuel , Reis Luís , Ribeiro António , Leite Marco 
Published: January 2023

AbstractAdditive manufacturing (AM) of polymer large parts is a technological research area with great growth potential if the main barriers to its implementation are successfully addressed. In this research, a review of large-format AM (LFAM) processes for polymers is presented, followed by market research concerning the identification of large-format polymer commercial printers. An overview was performed covering the current LFAM systems configurations and their control aspects. The design and modelling approaches related with the fabrication of polymer large parts by AM, and the materials currently being applied and under development, were described. Finally, a summary of LFAM applications with a focus in the Transportation, Academic, Construction and Energy sectors, was presented. The current main advances in the LFAM of polymers are linked with the possibility of producing large parts in a faster, cheaper, and reliable way. The market research analysis concerning results for all AM families involving polymer materials reveals that, currently, the material extrusion AM process family is potentially the most suitable to produce large parts, with a significant number of applications attesting its capability to produce such large-format components.