bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of a Behavioral Interruption Management Strategy on Improving Medication Administration Safety and Efficiency: A Feasibility Study
Authors: Schroers Ginger , Pfieffer Jill , Tell Dina , O’Rourke Jenny 
Published: May 2023

AbstractBackgroundWorldwide, interruptions are pervasive during nurse medication administration and associated with increased frequency and severity of errors. Interruptions also decrease task efficiency which can lead to delayed or omitted patient care. Interruptions cannot always be avoided in healthcare settings; thus, researchers recommend the use of interruption management strategies to mitigate interruptions’ negative effects.AimsTo investigate the feasibility and potential of a behavioral interruption management strategy to mitigate medication errors and improve task efficiency.DesignMulti-methods, two groups, repeated measures, pre-posttest design.MethodsData were collected January-March 2023. Volunteer undergraduate nursing students were randomly assigned to a control or intervention group. The intervention group received education and training on an interruption management strategy. Quantitative data were collected across three timepoints via direct observation of independent demonstrations of simulated medication administration. The simulated scenarios contained embedded interruptions. Outcomes measured included errors, medication preparation duration, and duration of time to implement the interruption management strategy. Descriptive statistics were analyzed using Microsoft Excel. Qualitative data of participants’ perceptions and use of the strategy were collected via semi-structured interviews.Thematic analysis was performed.Reporting MethodEquator guidelines were followed using the STROBE reporting method for the observed quantitative data. SRQR guidelines were followed in reporting the qualitative data.ResultsNineteen students participated in the study. Intervention group participants had larger improvements in errors and task durations compared to the control group. Implementation of the strategy averaged four seconds. Participants described the strategy as easy to use and remember, and voiced using the strategy outside of the study.ConclusionsFindings demonstrate that the study-described behavioral interruption management strategy was feasible to teach and implement, and associated with decreased errors and improved task efficiency. Use of the strategy has implications to increase patient safety through improved medication administration safety and efficiency. Future studies are recommended to gain a better understanding of the strategy’s effectiveness.
Emotional overeating affected nine in ten female students during the COVID-19 University closure: A cross-sectional study in France
Authors: Constant Aymery , Fortier Alexandra , Serrand Yann , Bannier Elise , Moirand Romain , Thibault Ronan , Coquery Nicolas , Godet Ambre , Val-Laillet David 
Published: May 2023

AbstractObjectivesTo estimate the proportion of female university students reporting overeating (EO) in response to emotions during the COVID-19 university closures, and to investigate social and psychological factors associated with this response to stress.DesignOnline survey gathered sociodemographic data, alcohol/drugs use disorders, boredom proneness and impulsivity using validated questionnaires, and EO using the Emotional Overeating Questionnaire (EOQ) assessing eating in response to six emotions (anxiety, sadness, loneliness, anger, fatigue, happiness), whose structure remains to be determined.ParticipantsSample of 302 female students from Rennes University, France.Main Outcome MeasureFrequencies of emotional overeating.AnalysisThe frequency of emotional overeating was expressed for each emotion as percentages. Exploratory Factor analyses (EFA) were used to determine EOQ structure and provide an index of all EOQ items used for further analysis. Linear regression models were used to explore relationships between EO and others covariates.ResultsNine in ten participants reported intermittent EO in the last 28 days, mostly during 6 to 12 days, in response to Anxiety (75.5%), Sadness (64.5%), Happiness (59.9%), Loneliness (57.9%), Tiredness (51.7%), and to a lesser extent to Anger (31.1%). EFA evidenced a one-factor latent variable reflecting “Distress-Induced Overeating” positively correlated with internal boredom proneness, tobacco use, attentional impulsivity, inability to resist emotional cues, and loss of control over food intake, and negatively with age and well-being. EO was unrelated to body mass index or substance abuse.Conclusion and ImplicationsNine in ten female students reported emotional overeating during the COVID-19 university closure. This response to stress was related to eating tendencies typical of young women, but also to personality/behavioral patterns such as boredom and impulsivity proneness. Better understanding of the mechanisms underlying EO in response to stress and lack of external/social stimulation would improve preventive interventions.
Patients with sickle cell disease presented dysregulated plasma Rb/K ratio and Gamma-glutamyl cycle in red blood cells
Authors: Bhatt Shruti , Mohapatra Amit Kumar , Rajesh Apratim Sai , Meher Satyabrata , Panda Pradip Kumar , Nanda Ranjan Kumar , Kundu Suman 
Published: May 2023

AbstractPatients suffering from sickle cell disease (SCD) present with multifactorial pathology, and a detailed understanding of it may help to develop novel therapeutics. In this study, the plasma elemental (24Mg,44Ca,57Fe,63Cu,66Zn,77Se,85Rb,208Pb, and39K) levels of SCD patients (n=10, male: 50%) and control groups (trait and healthy; n=10 each; male: 50%) were profiled using inductively coupled plasma mass spectrometry (ICP-MS). Additionally, comparative global erythrocyte metabolomics of SCD (n=5, male:100%) and healthy controls (n=5, male:100%) were carried out using liquid chromatography-mass spectrometry (LC-MS). SCD patients had higher plasma24Mg,44Ca,66Zn,208Pb, and39K levels and lower levels of57Fe,77Se, and85Rb compared to controls. These changes in elemental levels, with a decreased Rb/K ratio in the SCD group, may explain the observed frequent hemolysis and severe dehydration with oxidative stress in patients. Mass spectrometry analysis of red blood cells (RBCs of SCD (n=5) and healthy controls (n=5) identified 442 unique metabolic features which separately clustered both the study groups in principal component analysis (PCA). A set of 136 features showed differential (p<0.05; log2fold change>±1) regulation and was involved in D-glutamine/D-glutamate, sphingolipid, arginine biosynthesis, glutathione and glycine, serine and threonine metabolism. Interestingly, higher pyroglutamic acid levels were observed in the sickle shaped-RBCs indicating a perturbed gamma-glutamyl pathway in SCD patients. Supplementation of the depleted trace metals and targeting the perturbed metabolic pathways in the RBCs of SCD patients may provide avenues for the development of alternate therapeutics.Graphical abstract
Plasma neurofilament light chain predicts Alzheimer’s disease in patients with subjective cognitive decline and mild cognitive impairment: a longitudinal study
Authors: Mazzeo Salvatore , Bagnoli Silvia , Ingannato Assunta , Padiglioni Sonia , Giacomucci Giulia , Manganelli Alberto , Moschini Valentina , Balestrini Juri , Cavaliere Arianna , Morinelli Carmen , Galdo Giulia , Emiliani Filippo , Piazzesi Diletta , Crucitti Chiara , Frigerio Daniele , Polito Cristina , Berti Valentina , Sorbi Sandro , Nacmias Benedetta , Bessi Valentina 
Published: May 2023

AbstractBackgroundWe aimed to evaluate the accuracy of plasma neurofilament light chain (NfL) in predicting Alzheimer’s disease (AD) and the progression of cognitive decline in patients with subjective cognitive decline (SCD) and mild cognitive impairment (MCI).MethodsThis longitudinal cohort study involved 140 patients (50 with SCD, 73 with MCI, and 22 with AD dementia [AD-D]) who underwent plasma NfL and AD biomarker assessments (CSF, amyloid-PET, and18F-FDG-PET) at baseline. They were rated according to the A/T/N system and followed up for a mean time of 2.72±0.95 years to detect progression from SCD to MCI and from MCI to AD. Forty-eight patients (19 SCD, 29 MCI) also underwent plasma NfL measurements after two years after baseline.ResultsAt baseline, plasma NfL detected patients with biomarker profiles consistent with AD (A+/T+/N+ or A+/T+/N-) with high accuracy (AUC=0.82). We identified cut-off value of19.45 pg/mL for SCD and 20.45 pg/mL for MCI. During follow-up, nine SCD patients progressed to MCI (p-SCD), and 14 MCI patients developed AD dementia (p-MCI). The previously identified cut-off values provided good accuracy in identifying p-SCD (80% [95% C.I.=65.69:94.31]). The rate of NfL change was higher in p-MCI (3.52±4.06 pg/mL) compared to np-SCD (0.81±1.25 pg/mL) and np-MCI (−0.13±3.24 pg/mL) patients. A rate of change lower than 1.64 pg/mL per year accurately excluded progression from MCI to AD (AUC=0.954).ConclusionPlasma NfL concentration and change over time may be a reliable, non-invasive tool to detect AD and the progression of cognitive decline at the earliest stages of the disease.Key messagesWhat is already known on this topicPlasma NfL increase in SCD, MCI and AD and longitudinal changes in NfL are related to changes in brain atrophy and cognitive outcomes in AD. Nevertheless, the clinical value of plasma NfL in non-demented patients has been poorly explored.What this study addsPlasma NfL accurately predicts AD pathology and progression of cognitive decline in SCD and MCI. Repeated measurements of NfL may further increase the accuracy of this biomarkerHow this study might affect research, practice, or policyGiven its accessibility, blood-based NfL can assist clinicians in determining the optimal personalized diagnostic and therapeutic approach for individuals presenting with SCD or MCI, providing insights into the underlying biological mechanisms of cognitive decline, even in primary care settings.
Glymphatic system impairment contributes to the formation of brain edema after ischemic stroke
Authors: Zhu Juan , Mo Jiaying , Liu Kewei , Chen Quanfeng , Li Zheqi , He Yihua , Chang Yuan , Lin Chuman , Yu Mingjia , Xu Yikai , Tan Xiangliang , Huang Kaibin , Pan Suyue 
Published: May 2023

AbstractThe blood-brain barrier (BBB) damage has traditionally been considered to determine the occurrence and development of post-stroke brain edema, a devastating and life-threatening complication. However, no treatment strategy targeting BBB damage has been proven clinically effective in ameliorating brain edema. Here, we found that the extravasation of protein-rich fluids into the brain was not temporally correlated with edema formation after middle cerebral artery occlusion (MCAO) in mice, as brain edema reabsorption preceded BBB closure. Strikingly, the time course of edema progression matched well with the glymphatic system (GS) dysfunction after MCAO. Pharmacological enhancement of the GS function significantly alleviated brain edema developed on day 2 after MCAO, accompanied by less deposition of Aβ and better cognitive function. Conversely, functional suppression of the GS delayed the absorption of brain edema on day 7 after MCAO. Moreover, patients with ischemic stroke revealed a consistent trend of GS dysfunction after reperfusion as MCAO mice, which was correlated with the severity of brain edema and functional outcomes. Collectively, these findings indicate that the GS is a key contributor to the formation of brain edema after ischemic stroke, and targeting the GS may be a promising strategy for the treatment of brain edema in ischemic stroke.One Sentence SummaryThe function of the glymphatic system is a key factor in determining the formation or resolution of brain edema after ischemic strokeGraphical Abstract
Brain fingerprint changes across the menstrual cycle correlate with emotional state
Authors: Cipriano Lorenzo , Liparoti Marianna , Lopez Emahnuel Troisi , Sarno Laura , Lucidi Fabio , Sorrentino Pierpaolo , Sorrentino Giuseppe 
Published: May 2023

AbstractBackgroundMenstrual cycle (MC) is the cyclical phenomenon with the greatest impact on women’s mood and behavior. To date, little is known about the potential mechanism and neuroanatomical correlates of behavioral and emotional fluctuations across the MC. Brain connectome fingerprinting, a recently introduced technique in the field of brain network analysis, represents a valid approach in assessing the subject-specific connectivity and in predicting clinical impairment in several neurological diseases. Nevertheless, its performance, and clinical utility, in healthy individuals has not yet been investigated.MethodsWe conducted the Clinical Connectome Fingerprint (CCF) analysis on source-reconstructed magnetoencephalography signals in a cohort of 24 women across the MC.ResultsAll the parameters of identifiability did not differ according to the MC phases. The peri-ovulatory and mid-luteal phases showed a less stable, more variable over time, brain connectome compared to the early follicular phase. This difference in brain connectome stability (especially in the posterior brain regions) was able to significantly predict self-esteem, wellbeing, and mood.ConclusionThese results confirm the high reliability of the CCF and its independence from the MC phases and, at the same time, provide neuroanatomical correlates of the emotional and mood aspects that change across the MC.
A rare genetic disorder provides insights into mechanisms of early-onset neurodegeneration
Authors: Badja Cherif , Momen Sophie , Koh Gene Ching Cheik , Boushaki Soraya , Roumeliotis Theodoros I. , Kozik Zuza , Jones Ian , Bousgouni Vicky , Dias João M. L. , Krokidis Marios G. , Young Jamie , Chen Hongwei , Yang Ming , Docquier France , Memari Yasin , Valcarcel-Jimenez Lorea , Gupta Komal , Kong Li Ren , Fawcett Heather , Robert Florian , Zhao Salome , Degasperi Andrea , Davies Helen , Harris Rebecca , Frezza Christian , Chatgilialoglu Chryssostomos , Sarkany Robert , Lehmann Alan , Bakal Chris , Choudhary Jyoti , Fassihi Hiva , Nik-Zainal Serena 
Published: May 2023

AbstractXeroderma pigmentosum (XP) is characterized by defective repair of ultraviolet radiation(UVR)-induced DNA damage. Patients have UVR hypersensitivity and increased skin cancer risk. Effective photoprotection has reduced childhood cancer-related deaths, but revealed adolescence-onset neurodegeneration, arising through unknown mechanisms. Here, we investigate XP neurodegeneration using pluripotent stem cells derived from XP patients and healthy relatives, performing functional multi-omics on samples during neuronal differentiation. We find endoplasmic reticulum stress is upregulated, preceded by oxidative stress, causing substantial 5’,8-cyclopurine and 8-oxopurine DNA damage. Critically, XP neurons exhibit inappropriate downregulation of the protein clearance ubiquitin-proteasome system (UPS). Chemical enhancement of UPS activity improves phenotypes, albeit inadequately, implying that early detection/prevention strategies are necessary to produce clinically impactful outcomes. Thus, we develop an early detection assay predicting neurodegeneration in at-risk patients.
40HZ photoacoustic interventions combined with blue light improve brain function and sleep quality in a healthy population
Authors: Xu Xiaojun , Gong Zhuping , Jin Kaixiu , Huang Peiyu , Zhou Cheng , Zeng Qingze , Teng Junhu , Liu Ziyu , Zhang Huajiang , Xu Qian , Chen Yanling , Fang Cong , Zhang Minming 
Published: May 2023

AbstractRecent studies suggest that 40Hz photoacoustic stimulation is beneficial for improving cognition, and is safe and effective in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). It has been reported that the healthy population responds more strongly to the 40 Hz intervention compared to MCI and AD patients. Therefore, the aim of this study was to explore the effectiveness of 40 Hz photoacoustics in preventing cognitive impairment and improving sleep quality in the healthy population.Four weeks of 40 Hz intervention significantly improved sleep quality (PSQI) (p=0.028) and enhanced functional connectivity in the hippocampus and default mode network (DMN) (in the cognitively impaired population, functional connectivity showed a decreasing trend). These results were consistent with findings from the FDA clinical trial on MCI/AD patients that showed enhanced connectivity of the core regions PCC and mPFC within the DMN network. No serious adverse effects were reported throughout the intervention.This study is the first to validate the efficacy and safety of a 40 Hz photoacoustic intervention in a healthy population, suggesting its potential in preventing cognitive decline in a healthy population.
Neurofeedback-enabled beta power control with a fully implanted DBS system in patients with Parkinson’s disease
Authors: Rohr-Fukuma Manabu , Stieglitz Lennart H. , Bujan Bartosz , Jedrysiak Piotr , Oertel Markus F. , Salzmann Lena , Baumann Christian R. , Imbach Lukas L. , Gassert Roger , Bichsel Oliver 
Published: May 2023

AbstractParkinsonian motor symptoms are linked to pathologically increased beta oscillations in the basal ganglia. Studies with externalised deep brain stimulation electrodes showed that Parkinson patients were able to rapidly gain control over these pathological basal ganglia signals through neurofeedback. Studies with fully implanted deep brain stimulation systems duplicating these promising results are required to grant transferability to daily application. In this study, seven patients with idiopathic Parkinson’s disease and one with familial Parkinson’s disease were included. In a postoperative setting, beta oscillations from the subthalamic nucleus were recorded with a fully implanted deep brain stimulation system and converted to a real-time visual feedback signal. Participants were instructed to perform bidirectional neurofeedback tasks with the aim to modulate these oscillations. While receiving regular medication and deep brain stimulation, participants were able to significantly improve their neurofeedback ability and achieved a significant decrease of subthalamic beta power (median reduction of 31% in the final neurofeedback block). We could demonstrate that a fully implanted deep brain stimulation system can provide visual neurofeedback enabling patients with Parkinson’s disease to rapidly control pathological subthalamic beta oscillations.
Wastewater-based reproduction numbers and projections of COVID-19 cases in multiple cities in Japan, 2022
Authors: Miyazawa Shogo , Wong TingSam , Ito Genta , Iwamoto Ryo , Watanabe Kozo , van Boven Michiel , Wallinga Jacco , Miura Fuminari 
Published: May 2023

AbstractBackgroundWastewater surveillance has expanded globally to monitor the spread of infectious diseases. An inherent challenge is substantial noise and bias in wastewater data due to their sampling and quantification process, leading to the limited applicability of wastewater surveillance as a monitoring tool and the difficulty.AimIn this study, we present an analytical framework for capturing the growth trend of circulating infections from wastewater data and conducting scenario analyses to guide policy decisions.MethodsWe developed a mathematical model for translating the observed SARS-CoV-2 viral load in wastewater into effective reproduction numbers. We used an extended Kalman filter to infer underlying transmissions by smoothing out observational noise. We also illustrated the impact of different countermeasures such as expanded vaccinations and non-pharmaceutical interventions on the projected number of cases using three study areas in Japan as an example.ResultsOur analyses showed an adequate fit to the data, regardless of study area and virus quantification method, and the estimated reproduction numbers derived from wastewater data were consistent with notification-based reproduction numbers. Our projections showed that a 10-20% increase in vaccination coverage or a 10% reduction in contact rate may suffice to initiate a declining trend in study areas.ConclusionOur study demonstrates how wastewater data can be used to track reproduction numbers and perform scenario modelling to inform policy decisions. The proposed framework complements conventional clinical surveillance, especially when reliable and timely epidemiological data are not available.
Center Related Variation in Hospitalization Cost for Patients undergoing Percutaneous Left Atrial Appendage Occlusion
Authors: Patil Shivaraj , Rojulpote Chaitanya , Bhattaru Abhijit , Atri Avica , Atri Viha , Khraisha Ola , Mainigi Sumeet 
Published: May 2023

AbstractBackgroundThe commercial use of percutaneous LAAO with the Watchman device is increasing in the United States. The purpose of this study was to evaluate center related variation in total hospital costs for Watchman device implantation and identify factors associated with high hospital costs at a national level.MethodsAll adults undergoing elective LAAO with Watchman were identified in the 2016 to 2018 National Inpatient Database. Mixed models were used to evaluate the impact of center on total hospital costs adjusting for patient and center characteristics, and length of stay.ResultsA total of 30,175 patients underwent Watchman device implantation at a median cost of $24,500 and demonstrated significant variability across admissions (inter-decile range, $13,900-37,000). Nearly 13% of the variability in patient-level costs was related to the center performing the procedure rather than patient factors. Higher volume centers had lower total costs and demonstrated lesser total cost variation. Centers with low procedural volume, occurrence of procedural complications, congestive heart failure, and length of stay were independent predictors of a high-cost hospitalization. Though complications were associated with increased expenditure, they did not explain the observed cost variation related to the center.ConclusionA significant proportion of variation in total hospital cost was attributable to the center performing the procedure. Addressing variability of Watchman-related costs is necessary to achieve high-quality value-based care.