bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term trends of local bird populations based on monitoring schemes: are they suitable for justifying management measures?
Authors: Hernández-Navarro Antonio J. , Robledano Francisco , Jiménez-Franco María V. , Royle J. Andrew , Calvo José F. 
Published: September 2023

AbstractLocal biodiversity monitoring is important to assess the effects of global change, but also to evaluate the performance of landscape and wildlife protection, since large-scale assessments may buffer local fluctuations, rare species tend to be underrepresented, and management actions are usually implemented on local scales. We estimated population trends of 58 bird species using open-population N-mixture models based on count data in two localities in southeastern Spain, which have been collected according to a citizen science monitoring program (SACRE, Monitoring Common Breeding Birds in Spain) over 21 and 15 years, respectively. We performed different abundance models for each species and study area, accounting for imperfect detection of individuals in replicated counts. After selecting the best models for each species and study area, empirical Bayes methods were used for estimating abundances, which allowed us to calculate population growth rates (λ) and finally population trends. We also compared the two local population trends and related them with national and European trends, and species functional traits (phenological status, dietary, and habitat specialization characteristics). Our results showed increasing trends for most species, but a weak correlation between populations of the same species from both study areas. In general, local population trends were consistent with the trends observed at national and continental scales, although contrasting patterns exist for several species, mainly with increasing local trends and decreasing Spanish and European trends. Moreover, we found no evidence of a relationship between population trends and species traits. We conclude that using open-population N-mixture models is an appropriate method to estimate population trends, and that citizen science-based monitoring schemes can be a source of data for such analyses. This modeling approach can help managers to assess the effectiveness of their actions at the local level in the context of global change.
The New Zealand landslide dam database, v1.0
Authors: Morgenstern Regine , Wolter Andrea , Cox Simon C. , Lukovic Biljana , Bain Dan , Sirohi Akansha , Bruce Zane , Jones Katie , Rosser Brenda , Townsend Dougal , Massey Chris 
Published: September 2023

AbstractLandslide dams, forming when a landslide blocks a watercourse, are significant components of slope-river systems. Dams can fail suddenly and catastrophically, threatening downstream populations and structures. So it is important to understand where they could form, how long they persist in the landscape, and the extent of downstream inundation once they fail. To investigate dam formation, longevity, and stability effectively in Aotearoa New Zealand, we present version 1.0 of the New Zealand Landslide Dam Database (NZLDD). The database includes compilation, mapping, and/or remapping of 1036 dams, including those generated by the 2016 Kaikōura Earthquake. A representative subset of 265 dams was selected to analyse dam stability and breaching in detail (ongoing work). The database architecture, description of datasets included, attribute definitions, and some summary statistics are presented here. Many dams in the database have formed in greywacke bedrock terrain, by earthquake-triggered rock avalanches, falls, and slides. Most are small (Dam Type I—small dam that does not reach opposite valley side), and have since failed and no longer impede or impound water. The NZLDD represents a significant increase in catalogued landslide dams—almost doubling the existing number of known and studied dams worldwide.
The prevalence of grandparental childcare in Europe: a research update
Authors: Zanasi Francesca , Arpino Bruno , Bordone Valeria , Hank Karsten 
Published: September 2023

AbstractWe investigate (a) how the proportion of European grandparents providing childcare changed over a period of 15 years, (b) how these proportions differ by gender and education, and (c) how countries not covered in earlier analyses fit into previously identified regional patterns of grandparental childcare in Europe. Using data from Waves 1, 2, and 8 of the Survey of Health, Ageing and Retirement in Europe (SHARE), our descriptive analysis provides estimates of the prevalence and intensity of grandparental childcare in 26 European countries as well as of the changes therein over time and across socio-demographically defined groups. Overall, the prevalence and intensity of grandparental childcare in Europe has remained fairly stable over time, with minor increases. Proportions of grandparents providing any childcare strongly vary, however, across countries (from 24 to 60%). Grandmothers are generally more likely to provide childcare than grandfathers, while differences based on educational levels are less clear-cut. Central and southeastern Europe, representing the bulk of the ‘new’ countries in the analysis, exhibit patterns of grandparental childcare closely resembling those observed in Mediterranean countries. Our analysis revealed an overall stability over time rather than change in grandparents’ provision of childcare in Europe, with substantial variations across welfare state regimes and within countries when accounting for grandparents’ gender and educational levels. Including countries that had previously been excluded from other studies challenges the ‘narrative’ that has emerged around a negative macrolevel association between the provision of extensive and intensive grandparental childcare.
A synergistic effect of fibrous carboxymethyl cellulose with equine collagen improved the hemostatic properties of freeze-dried wound dressings
Authors: Sedlář M. , Kacvinská K. , Fohlerová Z. , Izsák D. , Chalupová M. , Suchý P. , Dohnalová M. , Sopuch T. , Vojtová L. 
Published: September 2023

AbstractBleeding is one of the most commonly occurring injuries; it can be painful and even life-threatening condition. The hemostats are substances that promote blood clotting and fasten hemostasis. In this paper, we evaluated the hemostatic effect of freeze-dried wound dressings based on equine collagen, porcine collagen, fibrous carboxymethyl cellulose (CMC) and their mixtures. The wound dressings were investigated for their morphological structure, chemical structure, absorption properties, in vitro hemostasis, cytotoxicity assay and lastly, for in vivo hemostasis. We have found out that adding fibrous CMC into collagen-based hemostatic wound dressings creates a strong synergistic effect, which significantly improves absorption capacity by almost doubling it, as well as supports clotting time. Based on the in vivo studies on partial nephrectomy in rats, the time needed for achieving hemostasis was significantly lower due to the synergy of collagen and CMC. Our materials were compared to the commonly used hemostatic sealing patch on the market (Tachosil) during the in vivo testing, and sample of a mixture of equine collagen and CMC showed better hemostatic efficacy.
Graphical abstract
Norwegian higher education futures
Authors: Bleiklie Ivar 
Published: September 2023

Abstract
The paper deals with the future of Norwegian higher education as part of a Nordic project on higher education futures. To identify future scenarios for Norwegian higher education (HE), the paper uses the theoretical lens of historical institutionalism to focus on scenario building. Like in the other Nordic countries, Norwegian HE and research are characterized by easily accessible and free public HE provision, high participation rates, and a high level of investment in HE and research. However, the question is this: If we look back at the development of Norwegian HE the last decades, to what extent can we expect present developments to persist and to what extent can we expect more or less sharp breaks and deviations from past and present developments? Departing from an institutionalist position, two historically grounded visions and related scenarios are identified: an academic excellence scenario and a national service scenario. The scenarios reflect tensions between different visions of the shape, emphasis, and orientation of HE and research. The empirical focus is on the developments of HE along five dimensions: growth, systemic integration, academic drift, labor market relevance, and governance. First, the conceptual approach is presented, outlining the use of scenarios and an institutionalist approach to thinking about the future of HE. Secondly, the paper outlines the five trends regarding past and ongoing developments. Third, some ideas about future developments are outlined, before the conclusion is drawn.
SAWIT: A small-sized animal wild image dataset with annotations
Authors: Nguyen Thi Thu Thuy , Eichholtzer Anne C. , Driscoll Don A. , Semianiw Nathan I. , Corva Dean M. , Kouzani Abbas Z. , Nguyen Thanh Thi , Nguyen Duc Thanh 
Published: September 2023

AbstractComputer vision has found many applications in automatic wildlife data analytics and biodiversity monitoring. Automating tasks like animal recognition or animal detection usually require machine learning models (e.g., deep neural networks) trained on annotated datasets. However, image datasets built for general purposes fail to capture realistic conditions of ecological studies, and existing datasets collected with camera-traps mainly focus on medium to large-sized animals. There is a lack of annotated small-sized animal datasets in the field. Small-sized animals (e.g., small mammals, frogs, lizards, arthropods) play an important role in ecosystems but are difficult to capture on camera-traps. They also present additional challenges: small animals can be more difficult to identify and blend more easily with their surroundings. To fill this gap, we introduce in this paper a new dataset dedicated to ecological studies of small-sized animals, and provide benchmark results of computer vision-based wildlife monitoring. The novelty of our work lies on SAWIT (small-sized animal wild image dataset), the first real-world dataset of small-sized animals, collected from camera traps and in realistic conditions. Our dataset consists of 34,434 images and is annotated by experts in the field with object-level annotations (bounding boxes) providing 34,820 annotated animals for seven animal categories. The dataset encompasses a wide range of challenging scenarios, such as occlusions, blurriness, and instances where animals blend into the dense vegetation. Based on the dataset, we benchmark two prevailing object detection algorithms: Faster RCNN and YOLO, and their variants. Experimental results show that all the variants of YOLO (version 5) perform similarly, ranging from 59.3% to 62.6% for the overall mean Average Precision (mAP) across all the animal categories. Faster RCNN with ResNet50 and HRNet backbone achieve 61.7% mAP and 58.5% mAP respectively. Through experiments, we indicate challenges and suggest research directions for computer vision-based wildlife monitoring. We provide both the dataset and the animal detection code at https://github.com/dtnguyen0304/sawit.
Urokinase-Type Plasminogen Activator Receptor (uPAR) Expression and [64Cu]Cu-DOTA-AE105 uPAR-PET/CT in Patient-Derived Xenograft Models of Oral Squamous Cell Carcinoma
Authors: Lawaetz Mads , Binderup Tina , Christensen Anders , Juhl Karina , Lelkaitis Giedrius , Lykke Eva , Knudsen Line , von Buchwald Christian , Kjaer Andreas 
Published: September 2023

Abstract
Purpose
[64Cu]Cu-DOTA-AE105 urokinase-type plasminogen activator receptor (uPAR)-PET/CT is a novel and promising imaging modality for cancer visualization, although it has not been tested in head and neck cancer patients nor in preclinical models that closely resemble these heterogenous tumors, i.e., patient-derived xenograft (PDX) models. The aim of the present study was to establish and validate oral squamous cell carcinoma (OSCC) PDX models and to evaluate [64Cu]Cu-uPAR-PET/CT for tumor imaging in these models.

Procedures
PDX flank tumor models were established by engrafting tumor tissue from three patients with locally advanced OSCC into immunodeficient mice. [64Cu]Cu-DOTA-AE105 was injected in passage 2 (P2) mice, and [64Cu]Cu-uPAR-PET/CT was performed 1 h and 24 h after injection. After the last PET scan, all animals were euthanized, and tumors dissected for autoradiography and immunohistochemical (IHC) staining.

Results
Three PDX models were established, and all of them showed histological stability and unchanged heterogenicity, uPAR expression, and Ki67 expression through passages. A significant correlation between uPAR expression and tumor growth was found. All tumors of all models (n=29) showed tumor uptake of [64Cu]Cu-DOTA-AE105. There was a clear visual concordance between the distribution of uPAR expression (IHC) and [64Cu]Cu-DOTA-AE105 uptake pattern in tumor tissue (autoradiography). No significant correlation was found between IHC (H-score) and PET-signal (SUVmax) (r=0.34; p=0.07).

Conclusions
OSCC PDX models in early passages histologically mimic donor tumors and could serve as a valuable platform for the development of uPAR-targeted imaging and therapeutic modalities. Furthermore, [64Cu]Cu-uPAR-PET/CT showed target- and tumor-specific uptake in OSCC PDX models demonstrating the diagnostic potential of this modality for OSCC patients.
Associations between environmental heavy metals exposure and preserved ratio impaired spirometry in the U.S. adults
Authors: Chen Chen , Zhang Shunan , Yang Ting , Wang Chen , Han Guiling 
Published: September 2023

AbstractWe examined 9556 individuals aged 18 to 79 years who had information on spirometry testing and heavy metals and used multivariable logistic or linear regression to evaluate associations between serum levels of cadmium, lead, and mercury and PRISm and lung function in U.S. adults, which were conducted first in all participants, and then separately in never/former smokers and current smokers. The overall prevalence of PRISm was 7.02%. High levels of serum cadmium were significantly associated with PRISm in all individuals, no matter in never/former smokers (quartile 4 vs 1, the OR = 2.517, 95% CI = 1.376–4.604, p-trend = 0.0077) and current smokers (quartile 4 vs 1, the OR = 2.201, 95% CI = 1.265–3.830, p-trend = 0.0020). Serum lead and mercury were not significantly correlated with PRISm, regardless of smoking status. Serum cadmium was strongly correlated with lower FEV1/FVC, regardless of smoking status. Besides, serum cadmium was also significantly related to lower FVC % predicted in never/former smokers and lower FEV1% predicted in current smokers. Serum lead was strongly correlated with lower FVC % predicted and FEV1/FVC in all individuals and never/former smokers. And serum mercury was significantly associated with decrements in FVC % predicted in all individuals and current smokers. These findings demonstrate that serum cadmium is associated with a higher risk of PRISm and lower lung function, with the most significant effect on FEV1/FVC in particular. Our results also indicate that exposure to lead and mercury negatively affects lung function in never/former smokers and current smokers, respectively.
Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors
Authors: Mariner Blaise L. , Rodriguez Antonio S. , Heath Olivia C. , McCormick Mark A. 
Published: September 2023

AbstractWe have recently shown that multiple tRNA synthetase inhibitors can greatly increase lifespan in multiple models by acting through the conserved transcription factor ATF4. Here, we show that these compounds, and several others of the same class, can greatly upregulate mammalian ATF4 in cells in vitro, in a dose dependent manner. Further, RNASeq analysis of these cells pointed toward changes in protein turnover. In subsequent experiments here we show that multiple tRNA synthetase inhibitors can greatly upregulate activity of the ubiquitin proteasome system (UPS) in cells in an ATF4-dependent manner. The UPS plays an important role in the turnover of many damaged or dysfunctional proteins in an organism. Increasing UPS activity has been shown to enhance the survival of Huntington’s disease cell models, but there are few known pharmacological enhancers of the UPS. Additionally, we see separate ATF4 dependent upregulation of macroautophagy upon treatment with tRNA synthetase inhibitors. Protein degradation is an essential cellular process linked to many important human diseases of aging such as Alzheimer’s disease and Huntington’s disease. These drugs’ ability to enhance proteostasis more broadly could have wide-ranging implications in the treatment of important age-related neurodegenerative diseases.
Sex differences in biological aging and the association with clinical measures in older adults
Authors: Phyo Aung Zaw Zaw , Fransquet Peter D. , Wrigglesworth Jo , Woods Robyn L. , Espinoza Sara E. , Ryan Joanne 
Published: September 2023

AbstractFemales live longer than males, and there are sex disparities in physical health and disease incidence. However, sex differences in biological aging have not been consistently reported and may differ depending on the measure used. This study aimed to determine the correlations between epigenetic age acceleration (AA), and other markers of biological aging, separately in males and females. We additionally explored the extent to which these AA measures differed according to socioeconomic characteristics, clinical markers, and diseases. Epigenetic clocks (HorvathAge, HannumAge, PhenoAge, GrimAge, GrimAge2, and DunedinPACE) were estimated in blood from 560 relatively healthy Australians aged ≥ 70 years (females, 50.7%) enrolled in the ASPREE study. A system-wide deficit accumulation frailty index (FI) composed of 67 health-related measures was generated. Brain age and subsequently brain-predicted age difference (brain-PAD) were estimated from neuroimaging. Females had significantly reduced AA than males, but higher FI, and there was no difference in brain-PAD. FI had the strongest correlation with DunedinPACE (range r: 0.21 to 0.24 in both sexes). Brain-PAD was not correlated with any biological aging measures. Significant correlations between AA and sociodemographic characteristics and health markers were more commonly found in females (e.g., for DunedinPACE and systolic blood pressure r = 0.2, p < 0.001) than in males. GrimAA and Grim2AA were significantly associated with obesity and depression in females, while in males, hypertension, diabetes, and chronic kidney disease were associated with these clocks, as well as DunedinPACE. Our findings highlight the importance of considering sex differences when investigating the link between biological age and clinical measures.
Learning during a pandemic: an Activity Theory analysis of the challenges experienced by Aotearoa/New Zealand university students
Authors: Gedera Dilani , Forbes Dianne , Brown Cheryl , Hartnett Maggie , Datt Ashwini 
Published: September 2023

AbstractThe worldwide disruption of higher education during the Covid-19 pandemic has been studied from the viewpoints of institutions and teachers, with some attention to students’ health and learning challenges. Attempts to theorise the diverse and conflicting challenges faced by students learning online during the pandemic have been limited. It is helpful to analyse students’ experiences as part of an activity system in order to unravel the system’s elements and determine contradictions that occur. This study adopted a mixed methods approach to investigate students’ online learning experiences at all eight New Zealand universities during the pandemic. Data obtained via a large-scale online survey, followed by focus groups and individual interviews, is presented in light of an Activity Theory framework. Findings show that students’ key challenges were associated with new tools and technologies, lack of interaction and social connection, lack of routine and space, and clashing commitments due to multiple roles and responsibilities. Contradictions can be a driving force for change and development in teaching and learning contexts. We conclude with recommendations for tertiary institutions, teachers, learning designers and students to inform future learning and teaching plans.
Rearrangement Events on Circular Genomes
Authors: Stevenson Joshua , Terauds Venta , Sumner Jeremy 
Published: September 2023

AbstractEarly literature on genome rearrangement modelling views the problem of computing evolutionary distances as an inherently combinatorial one. In particular, attention is given to estimating distances using the minimum number of events required to transform one genome into another. In hindsight, this approach is analogous to early methods for inferring phylogenetic trees from DNA sequences such as maximum parsimony—both are motivated by the principle that the true distance minimises evolutionary change, and both are effective if this principle is a true reflection of reality. Recent literature considers genome rearrangement under statistical models, continuing this parallel with DNA-based methods, with the goal of using model-based methods (for example maximum likelihood techniques) to compute distance estimates that incorporate the large number of rearrangement paths that can transform one genome into another. Crucially, this approach requires one to decide upon a set of feasible rearrangement events and, in this paper, we focus on characterising well-motivated models for signed, uni-chromosomal circular genomes, where the number of regions remains fixed. Since rearrangements are often mathematically described using permutations, we isolate the sets of permutations representing rearrangements that are biologically reasonable in this context, for example inversions and transpositions. We provide precise mathematical expressions for these rearrangements, and then describe them in terms of the set of cuts made in the genome when they are applied. We directly compare cuts to breakpoints, and use this concept to count the distinct rearrangement actions which apply a given number of cuts. Finally, we provide some examples of rearrangement models, and include a discussion of some questions that arise when defining plausible models.