bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assédio sexual na caserna: um crime silencioso
Authors: Ferreira Gisleia Aparecida 
Published: July 2023

O crime de assédio sexual foi tipificado na legislação penal brasileira em 2001, criminalizando esta prática abusiva tão comum e banalizada em tempos anteriores. O assédio sexual, infelizmente, é uma prática cultural, que envolve a honra das mulheres, e que muitas vezes não é exposto para outras pessoas, muito menos denunciado como crime. O objetivo do presente estudo foi relatar situações de assédio sexual no ambiente militar, e as consequências destes atos. A metodologia utilizada foi a pesquisa bibliográfica e jurisprudencial, com apoio do google acadêmico bem como buscas em sites de jurisprudências sobre o tema. Após estas buscas, houve análise qualitativa dos casos encontrados, e ao final foi apresentado um caso envolvendo um oficial da Polícia Militar do Paraná, cujo julgamento gerou repercussão nacional. Questionou-se: mesmo na atualidade, com inúmeros direitos sendo protegidos legalmente, casos de assédio sexual podem ficar impunes? Existem diferenciações entre assédio sexual no meio militar e assédio sexual em ambiente de trabalho civil? Observadas várias jurisprudências a respeito do tema, concluindo-se que a vítima tem que estar muito forte psicologicamente e ter respaldo da instituição para denunciar casos de assédio sexual, pois haverá certamente revitimização contra ela, bem como outras consequências, devido ao machismo estrutural e relações hierárquicas militares, dificultando punições exemplares.
Perfil e prevalência da Tuberculose no estado de Alagoas no período de 2018 a 2022
Authors: De Sousa Saulo Batista , Vieira Matheus Emannuel Santos , Da Luz Gabriela Aragão , Gomes Luis Henrique Alves , Pol-Fachin Laércio 
Published: July 2023

Introdução: A tuberculose (TB) é uma enfermidade infecto-contagiosa que afeta principalmente o trato respiratório do indivíduo e é causada por uma bactéria patogênica específica denominada Mycobacterium tuberculosis (MT). Essa doença atinge o Brasil e o mundo, sendo considerada um grande problema de saúde pública. Segundo a Organização Mundial da Saúde (OMS), mais de duas bilhões de pessoas estão infectadas por MT, o que corresponde a aproximadamente um terço da população mundial. No Brasil a região predominante é o subúrbio das grandes cidades quando se trata da população mais acometida. Atrelado a falta de higiene e moradia insalubre que contribuem para a disseminação do bacilo na região. Objetivo: Avaliar a epidemiologia e prevalência da infecção em um estado do nordeste brasileiro, bem como compará-lo com a situação geral do país e com dados encontrados na literatura. Metodologia: Trata-se de um estudo descritivo, de caráter quantitativo, da base de dados SINAN/DATASUS, dentre eles: pacientes com tuberculose a partir de variáveis como: sexo, ano de diagnóstico nos últimos cinco anos no estado de Alagoas e no Brasil. Resultados e discussões: O número total de pacientes diagnosticados com tuberculose no Estado de Alagoas foi de 5985 novos casos durante os anos de 2018 a 2022. Os alagoanos com tuberculose correspondem a aproximadamente 1,29%% do total nacional. A análise dos dados do SINAN em Alagoas mostrou convergência das informações com a literatura, revelando a prevalência do sexo masculino, com quase o dobro do número de casos do sexo feminino. possível justificativa para a redução importante do número de casos nos últimos dois anos se deve ao diagnóstico precoce e adequado, reforçado pelo Ministério da Saúde. Conclusão: Diante do cenário muito prevalente de infecção Tuberculose, torna-se necessário que novas políticas públicas surjam em favor da redução da desigualdade social, econômica e regional.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KESIAPSIAGAAN PERAWAT AMBULANS GAWAT DARURAT 118 DALAM MENGHADAPI KEGAWATDARURATAN BENCANA BANJIR DI DKI JAKARTA
Authors: Hardiyati Anastasia , Muhafilah Ilah 
Published: July 2023

Latar belakang: Kesiapsiagaan merupakan serangkaian kegiatan yang dilakukan untuk mengantisipasi bencana melalui pengorganisasian serta melalui langkah tepat guna dan berdaya guna. Perawat memiliki tanggung jawab untuk meminimalisir dampak bencana dengan manajemen bencana. Terdapat banyak faktor (pengetahuan, sikap, pengalaman bencana, sarana dan prasarana serta kebijakan) yang dapat mempengaruhi kesiapsiagaan perawat. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang berhubungan dengan kesiapsiagaan perawat Ambulans Gawat Darurat 118 dalam menghadapi kegawatdaruratan bencana banjir di DKI Jakarta
Metode penelitian: Penelitian ini menggunakan metode analisis deskriptif dengan pendekatan cross-sectional yang dilakukan pada tanggal 8 Juni 2018 di Ambulans Gawat Darurat 118 Jakarta. Teknik pemilihan sample yang digunakan adalah total sampling yaitu sebanyak 38 responden dan penelitian dilakukan pada tanggal 8 Juni 2018. Data di analisis menggunakan uji statistik Chi Square pada tingkat kemaknaan 95% (α 0,05) .
Hasil: Sebagian besar perawat yang bekerja di Ambulans Gawat Darurat 118 Jakarta memiliki tingkat kesiapsiagaan yang tinggi (60,5%). Hasil analisis bivariat menunjukkan bahwa adanya hubungan yang signifikan antara pengetahuan [ P Value = 0,006 ; OR = 9,500], sikap [ P Value = 0,018; OR = 7,125], pengalaman bencana [ P Value = 0,041 ; OR = 5,400], kebijakan [ P Value = 0,005 ; OR = 9,900] serta sarana dan prasarana [ P Value= 0,006 ; OR = 9,500] dengan kesiapsiagaan perawat.
Kesimpulan: Pengetahuan, sikap, pengalaman bencana, kebijakan serta sarana dan prasarana merupakan faktor- faktor yang berhubungan dengan kesiapsiagaan perawat. Perawat dan masyarakat diharapkan mampu bekerjasama dengan lintas sektor yang terkait dalam kesiapsiagaan banjir di DKI Jakarta guna meminimalkan jumlah korban saat bencana terjadi, mengurangi trauma pada korban, mencegah munculnya masalah kesehatan pasca bencana, dan memudahkan upaya tanggap darurat serta pemulihan yang cepat.
Screening differential circular RNA expression profiles and the potential role of hsa_circ_0085465 in liver cancer
Authors: Zhou Churen , Zhu Duo , Zhou Sibin , Wang Haofan , Huang Mingsheng 
Published: July 2023

ABSTRACT

Aims:
This study aimed to screen the circular RNAs (circRNAs) that are differentially expressed between liver cancer and paired paracarcinoma tissues and then elucidate their role in cancer progression.

Materials and Methods:
High-throughput sequencing of cancer and paired paracarcinoma tissues was followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of the parental genes of the differentially expressed circRNAs, which were also verified via real-time quantitative polymerase chain reaction analysis of the tissues. In addition, the function of selected circRNAs was determined using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4- sulfophenyl)-2H-tetrazolium (MTS) and transwell assays.

Results:
Total 218 and 121 circRNAs were differentially upregulated and downregulated, respectively; these were mainly enriched with GO and KEGG terms related to biological functions. From five representatives of the differentially expressed circRNAs, we selected hsa_circ_0085465 for further analysis, discovering that its overexpression promoted the proliferation, migration, and invasion of 97 L cells.

Conclusion:
Taken together, our results suggest that hsa_circ_0085465 is relevant to liver cancer progression.
Metastatic choriocarcinoma of the kidney in the absence of existing primary uterine tumor: A rare presentation
Authors: Pahwa Saloni , Sharma Anila , Kamboj Meenakshi , Gupta Gurudutt , Pasricha Sunil 
Published: July 2023

ABSTRACT
Gestational choriocarcinomas are malignant neoplasms generally arising in the uterus in women of childbearing age. These are aggressive tumors with a high incidence of metastasis to vascular organs such as the lung, liver, and brain. Renal metastasis is extremely rare with low incidence rate and very few cases have been reported in literature. Hereby, we report a rare case of metastatic choriocarcinoma to the kidney in a 29-year-old female 10 years after resection of a hydatidiform mole. The histopathological diagnosis was made on a nephrectomy specimen. Pelvic and abdominal scan did not show any abnormal radiological findings. She was started on first-line chemotherapy and showed a complete response. In conclusion, gestational or primary nongestational choriocarcinomas should always be considered as a differential diagnosis in young females of reproductive age group presenting with flank abdominal pain, unexplained hematuria, and atypical renal tumor histology.
Cisplatin-based combination therapy for cancer
Authors: Minerva  , Bhat Amrita , Verma Sonali , Chander Gresh , Jamwal Rajeshwer Singh , Sharma Bhawani , Bhat Audesh , Katyal Taruna , Kumar Rakesh , Shah Ruchi 
Published: July 2023

ABSTRACT
Cisplatin, that is, cis-diamminedichloroplatinum is a coordinate compound that is mainly preferred as prior treatment against several solid tumors and malignancies like ovaries, head and neck, testicular, and lung cancers because of its anticancer activity. Cisplatin binds at the N7 position of purine and forms adducts, leading to altered activity of DNA that triggers apoptosis. DNA damage is followed by several signaling pathways like induced oxidative stress, upregulated p53, mitogen-activated protein kinase (MAPK), and Jun N-terminal kinases (JNK) or Akt pathways along with induced apoptosis. Additionally, cisplatin treatment comes with few disadvantages such as toxic effects, that is, hepatotoxicity, cardiotoxicity, neurotoxicity, etc., and drug resistance. Furthermore, to overcome cisplatin resistance and toxicological effects, combination drug therapy has been considered. The aim of the review is to focus on the molecular mechanism of action of cisplatin and combination drug therapy to reduce the side effects in cancer therapy.
BRCA mutation carriers suffering from ovarian cancer as a model for treatment decision in higher lines – Place for platinum reinduction
Authors: Zikan Michal , Vecerova Livia , Dubova Olga , Sehnal Borek , Soukupova Jana 
Published: July 2023

ABSTRACT

Context:
Ovarian carcinoma is a malignancy with the highest mortality among gynecological cancers. Mutations in BRCA1/2 genes are believed to be a favorable prognostic factor and that, in general, the biological behavior of ovarian cancer in BRCA-positive individuals differs from others. However, some clinically relevant issues (i.e., prediction of response to chemotherapy and treatment of platinum-resistant BRCA-positive patients) remain unclear.

Aims:
(1) The aim of this study was to examine the prevalence of germline BRCA mutations in unselected recurrent ovarian cancer patient population, (2) analyze whether biological behavior of BRCA-positive tumors differs from others, and (3) analyze the effect of platinum reinduction in platinum-resistant BRCA-positive patients.

Settings and Design:
This was a single-institution retrospective analysis.

Subjects and Methods:
Consecutive recurrent ovarian cancer patients from years 2012 to 2020 were included; their BRCA1/2 mutational status was analyzed and correlated with progression-free survival (PFS), type of treatment, and response to treatment.

Statistical Analysis Used:
Statistical significance of differences between and among patients was tested for continuous variables by the Mann–Whitney U-test or the Kruskal–Wallis test; a maximum likelihood Chi-square test was used for categorical variables.

Results:
Two hundred and forty-three recurrent ovarian cancer patients were included. The median follow-up was 37 months. Pathogenic mutation in BRCA1 or BRCA2 gene was found in 18.1% of patients. There was no difference in PFS comparing BRCA-positive to BRCA-negative patients (median PFS: 10.2 vs. 10.1 months, P = 0.874); there was a difference in PFS comparing BRCA-negative versus BRCA-positive platinum-sensitive patients (9.4 vs. 14.3 months, P = 0.002). BRCA-positive platinum-resistant patients reinduced with platinum achieved a median PFS of 8 months (compared to those receiving nonplatinum treatment, median PFS: 4 months, P = 0.062).

Conclusions:
Germline BRCA mutations are not exclusive to platinum-sensitive ovarian cancer patients; even in platinum-resistant patients, mutation can be detected. We found no difference in PFS for platinum-sensitive BRCA-positive and BRCA-negative patients. Platinum reinduction may be considered for BRCA-positive platinum-resistant ovarian cancer patients to prolong PFS. Even these data describe only a small population, it supports the clinical practice of platinum-based chemotherapy use in platinum-resistant BRCA-positive patients.
Clinical study evaluating the effectiveness and efficiency of metrohex plus gel and diode laser therapy along with standard mechanical debridement for managing chronic periodontitis
Authors: Singh Gaurav , Chauhan Shailendra S. , Sharma Satendra , Sinha Aditya , Kulshrestha Saksham 
Published: July 2023

Aim
A study was carried out to determine how effective diode lasers and metrohex plus gel are at managing chronic periodontitis when compared to standard periodontal therapy.

Materials and methods
A total of 90 sites having periodontal probing depth more than or equal to 5 mm were included with patients aged around 35–60 years. Each group contains 30 sites as follows: group I laser-assisted new attachment procedure, group II metrohex plus gel, group III SRP alone.

Results
Based on the average GI value at baseline, 1 and 3 months, the values were 1.9 ± 0.67, 0.99 ± 0.26, and 0.89 ± 0.19, respectively. The mean PI* score decreased to 1.12 ± 0.31 at 1 month and 0.80 ± 0.31 at 3 months from 2.30 ± 0.58 at baseline. A periodontal probing depth reduction of 0.85 ± 0.03 mm was observed at 3 months for sites treated with laser, which was significantly higher than the reductions for sites treated with metrohex plus (metronidazole 10 mg + chlorhexidine gluconate 0.25% w/w and hyaluronic acid) and SRP alone. Periodontal probing depth reductions were not significantly different between groups I and II. Group II showed a 0.35 ± 0.11 mm improvement in clinical attachment level compared to group III.

Conclusion
As opposed to simple SRP, diode laser therapy and metrohex plus gel improve all clinical parameters in patients with periodontitis.
Advanced Algorithms to Predict Time-Dependent Atmospheric Corrosion Wastage of Low-Alloy and High-Strength Steels Based on Chemical Compositions
Authors: Zhang Yuelin , Zheng Ruyan 
Published: July 2023

The mathematical relationship between corrosion degree and time is referred to as a corrosion model. Existing corrosion models can only be used to predict the corrosion wastage of a certain material based on its available historical corrosion data, but the corrosion wastage of newer steel grades cannot be obtained if the data are not available. To solve this problem, two advanced algorithms, i.e., generalized regression neural network (GRNN) and optimizing grey model (OGM (1, N)), are introduced, based on which corrosion models can be obtained for steel classes even in the absence of historical corrosion data, as long as the chemical compositions of the material are known. First, the theoretical basis and operational procedures of GRNN and OGM (1, N) are introduced. Grey relational analysis of corrosion wastage influencing factors is subsequently conducted. Last, the time-dependent atmospheric corrosion wastages of Q345 and Q460 steels, two typical structural steel grades but their corrosion models have not been well established, are predicted based on their chemical compositions by these two advanced algorithms. The results show that the main chemical compositions that influence the atmospheric corrosion wastage of steels are C and S. Both GRNN and OGM (1, N) can accurately predict the corrosion wastage of the steels, and the predicted results can be fitted by quadratic function or power function, where the goodness of fit is greater than 0.95, which indicates a high fitting accuracy.
Levels of persistent organic pollutants (POPs) in the Antarctic atmosphere over time (1980 to 2021) and estimation of their atmospheric half-lives
Authors: Luarte Thais , Gómez-Aburto Victoria A. , Poblete-Castro Ignacio , Castro-Nallar Eduardo , Huneeus Nicolas , Molina-Montenegro Marco , Egas Claudia , Azcune Germán , Pérez-Parada Andrés , Lohmann Rainier , Bohlin-Nizzetto Pernilla , Dachs Jordi , Bengtson-Nash Susan , Chiang Gustavo , Pozo Karla , Galbán-Malagón Cristóbal J. 
Published: July 2023

Abstract. Persistent organic pollutants (POPs) are synthetic compounds that were
intentionally produced in large quantities and have been distributed in the
global environment, originating a threat due to their persistence,
bioaccumulative potential, and toxicity. POPs reach the Antarctic continent
through long-range atmospheric transport (LRAT). In these areas, low temperatures play a significant role in the environmental fate of POPs, retaining them for a long time due to cold trapping by diffusion and wet deposition, acting as a net sink for many POPs. However, in the current context of climate change, the remobilization of POPs that were trapped in water, ice, and soil for decades is happening. Therefore, continuous monitoring of POPs in polar air is necessary to assess whether there is a recent re-release of historical pollutants back to the environment. We reviewed the scientific literature on atmospheric levels of several POP families (polychlorinated biphenyls – PCBs, hexachlorobenzene – HCB, hexachlorocyclohexanes – HCHs, and dichlorodiphenyltrichloroethane – DDT) from 1980 to 2021. We estimated the atmospheric half-life using characteristic decreasing times (TD). We observed that HCB levels in the Antarctic atmosphere were higher than the other target organochlorine pesticides (OCPs), but HCB also displayed higher fluctuations and did not show a significant decrease over time. Conversely, the atmospheric levels of HCHs, some DDTs, and PCBs have decreased significantly. The estimated atmospheric half-lives for POPs decreased in the following order: 4,4' DDE (13.5 years) > 4,4' DDD (12.8 years) > 4,4' DDT (7.4 years) > 2,4' DDE (6.4 years) > 2,4' DDT (6.3 years) > α-HCH (6 years) > HCB (6 years) > γ-HCH (4.2 years). For PCB congeners, they decreased in the following order: PCB 153 (7.6 years) > PCB 138 (6.5 years) > PCB 101 (4.7 years) > PCB 180 (4.6 years) > PCB 28 (4 years) > PCB 52 (3.7 years) > PCB 118 (3.6 years). For HCH isomers and PCBs, the Stockholm Convention (SC) ban on POPs did have an impact on decreasing their levels during the last decades. Nevertheless, their ubiquity in the Antarctic atmosphere shows the problematic issues related to highly persistent synthetic chemicals.
ТЕХНОЛОГІЇ ХМАРНИХ ОБЧИСЛЕНЬ ТА ДИНАМІКА ЇХ РОЗВИТКУ
Authors: ЛЕМЕШКО Андрій Вікторович , АНТОНЕНКО Артем Васильович , СЛЮСАР Віталій Олександрович , БАХУРИНСЬКИЙ Дмитро Вадимович , КУЦЕНКО Микита Олександрович 
Published: July 2023

Хмарні обчислення розглядаються як технологія наступного покоління. Це веб-технологія, за допомогою якої користувачам надаються якісні послуги, включаючи дані та програмне забезпечення, на віддалених серверах. Хмарні обчислення схожі на аутсорсинг даних, оскільки зовнішній постачальник надає клієнту послуги зберігання даних. При цьому клієнти отримують хороший результат, без великих витрат на обладнання та програмування для зберігання інформації. Хмарні обчислення усувають необхідність мати повну інфраструктуру програмного та апаратного забезпечення для задоволення вимог клієнтів і додатків.
Цей вид технології можна розглядати як повний або неповний аутсорсинг апаратних і програмних ресурсів. Для доступу до хмарних програм потрібне швидке підключення до інтернету та стандартний Інтернет-браузер. Хмарна технологія пропонує масштабований доступ за запитом до спільного пулу ресурсів, розміщених у центрі обробки даних на сайті провайдера.
RITUALES DE INCLUSIÓN: EN EL MARGEN DE INTEGRACIÓN ESCOLAR EN CÁRCELES. ESTUDIO DESCRIPTIVO EN ESCUELAS DE SANTIAGO Y VALPARAÍSO
Authors: Ibarra Osorio Francisca , Mandujano Bustamante Fernando 
Published: July 2023

La inclusión educativa ha tomado especial relevancia en políticas públicas de Chile, una de sus principales respuestas son los programas de integración escolar (PIE) que buscan brindar y fortalecer los espacios educativos con recursos extras para quienes presenten necesidades educativas especiales. El acceso normado por el Decreto 170/2009. Esta investigación hace una descripción de ese proceso de inicio reciente, en un escenario extremo y complejo: la aplicación de los PIEs en la educación de personas jóvenes y adultas (EPJA), y además en contexto de encierro. El problema del estudio fue conocer la experiencia de los equipos PIE que se desempeñan en esos escenarios educacionales en las regiones de Valparaíso y Santiago. Se usó un diseño metodológico cualitativo basado en entrevistas en profundidad y una muestra dirigida. Los resultados evidencian las tensiones personales, adecuaciones y distorsiones que deben realizar los profesionales para brindar la atención requerida, se ven fuertemente determinados por la falta de adecuación del decreto 170, el contexto de encierro carcelario, la política de financiación regida por el váucher y las falencias de formación y perfeccionamiento profesional ad-hoc.
Carbon Nitride‐Based siRNA Vectors with Self‐Produced O2 Effects for Targeting Combination Therapy of Liver Fibrosis via HIF‐1α‐Mediated TGF‐β1/Smad Pathway
Authors: Liu Ming‐Xuan , Xu Li , Cai Yu‐Ting , Wang Ruo‐Jia , Gu Ying‐Ying , Liu Yan‐Chao , Zou Yu‐Jin , Zhao Yong‐Mei , Chen Jing , Zhang Xiao‐Ling 
Published: July 2023

AbstractHypoxia is an important feature, which can upregulate the hypoxia‐inducible factor‐1α (HIF‐1α) expression and promote the activation of hepatic stellate cells (HSCs), leading to liver fibrosis. Currently, effective treatment for liver fibrosis is extremely lacking. Herein, a safe and effective method is established to downregulate the expression of HIF‐1α in HSCs via targeted delivery of VA‐PEG‐modified CNs‐based nanosheets‐encapsulated (VA‐PEG‐CN@GQDs) HIF‐1α small interfering RNA (HIF‐1α‐siRNA). Due to the presence of lipase in the liver, the reversible release of siRNA can be promoted to complete the transfection process. Simultaneously, VA‐PEG‐CN@GQD nanosheets enable trigger the water splitting process to produce O2 under near‐infrared (NIR) irradiation, thereby improving the hypoxic environment of the liver fibrosis site and maximizing the downregulation of HIF‐1α expression to improve the therapeutic effect, as demonstrated in liver fibrosis mice. Such combination therapy can inhibit the activation of HSCs via HIF‐1α‐mediated TGF‐β1/Smad pathway, achieving outstanding therapeutic effects in liver fibrosis mice. In conclusion, this study proposes a novel strategy for the treatment of liver fibrosis by regulating the hypoxic environment and the expression of HIF‐1α at lesion site.