bluuebunny/crossref_metadata_2025_split huggingface dataset:
An adapter-based architecture for evaluating candidate solutions in energy system scheduling
Authors: Chlosta Malte , Liu Jianlei , Poppenborg Rafael , Lutz Richard , Förderer Kevin , Schlachter Thorsten , Hagenmeyer Veit 
Published: December 2022

AbstractIncreasing shares of volatile generation and non-steerable demand raise the need for automated control of the Energy Systems (ESs). Various solutions for management and schedule-based control of energy facilities exist today. However, the amount and diversity of applications lead to a multitude of different automated energy management solutions. Different optimization algorithms have proven more or less effective for energy management. The multitude of optimization algorithms and energy management solutions require flexible, modular, and scalable integrations. We present a novel Optimization Service (OS) for easily integrating optimization algorithms while evaluating candidate solutions in the context of ESs applications. We propose an adapter-based architecture using metadata and domain knowledge to bridge between clients, e.g. smart grid applications and optimization algorithms. The architecture interfaces different clients with optimizers in a flexible and modular way. The clients provide metadata-based descriptions of optimization jobs translated by OS. OS then interacts with optimizers and evaluates candidate solutions. A consistent definition of interfaces for clients and optimization algorithms facilitates the modular evaluation of candidate solutions. OS’s separation of client and optimization algorithms increases scalability by managing computational resources independently. We evaluate the presented architecture for scheduling a so-called Energy Hub (EH) as a test case describing a simulation scenario of a renewable EH embedded in grid scenarios from an industrial area in Karlsruhe, Germany. OS utilizes an Evolutionary Algorithm (EA) to optimize schedules for cost and strain on the electrical grid. The use case exemplifies OS’s advantages in a proof-of-concept evaluation.
Satranidazole-loaded chitosan/locust bean gum/xanthan gum polysaccharide composite multiunit pellets for colon targeting: in vitro–in vivo investigation
Authors: Mazumder Rana , Mahanti Beduin , Majumdar Subhabrota , Pal Rabindranath , Pahari Nilanjan 
Published: December 2022

Abstract
Background
The colon has a significant site to deliver numerous active materials for colonic diseases. Highly biodegradable polymers hold significant promise among the several techniques available to deliver the drug to the colon. This research aimed to prepare chitosan, locust bean gum and xanthan gum polysaccharide composite satranidazole multiunit pellets for colonic release and assesses the bioavailability with pharmacokinetic parameters after administration of satranidazole raw drug compared to multiunit pellets. Satranidazole multiple unit pellets were prepared based on chitosan, locust bean gum and xanthan gum, which were inexpensive and harmless. The bioavailability study was done by crossover design in which satranidazole raw drug and test formulation was administered to six healthy white albino rats.

Results
The pharmacokinetic analyses were estimated using the deconvolution of the plasma profile. Compared to the satranidazole drug used as a reference, for the pellets, the maximum plasma concentration was lower (35.02 ± 3.91 ng/ml vs. 51.07 ± 1.21 ng/ml for the satranidazole drug), and the time to attain maximum concentration was 2.50 ± 0.55 h for both drugs and test formulation. Colonic drug content was significantly higher than that of free administered drug.

Conclusion
The results indicate the acquired pharmacokinetic studies and colonic analysis established the reliability of the pharmaceutical technique and the ability to release satranidazole at the colonic site.

Graphical Abstract
NOHA: A Promising Biomarker for Determining Estrogen Receptor Status Among Patients With Breast Cancer in Resource-Constrained Settings
Authors: Serventi Furaha , Musyoka Augustine , Saunders Jamie , Mremi Alex , Mmbaga Blandina Theophil , Patrick Elizabeth , Mwakyembe Theresia , Jones Michael , Lucas F. Lee. , Miesfeldt Susan , Mohan Srinidi 
Published: December 2022

PURPOSE Challenges to breast cancer control in low-and middle-income countries exist because of constrained access to care, including pathology services. Immunohistochemistry (IHC)–based estrogen receptor (ER) analysis is limited-nonexistent because of few and inadequately staffed and equipped pathology laboratories. We have identified Nw-hydroxy-L-Arginine (NOHA) as a blood-based biomarker to distinguish ER status in US patients with breast cancer. Here, we examine NOHA's clinical utility as an ER IHC alternative in Tanzanian patients. MATERIALS AND METHODS Following informed consent, 70 newly diagnosed, known or suspected patients with breast cancer were enrolled at Kilimanjaro Christian Medical Center; basic, deidentified clinical and sociodemographic data were collected. For each, a needle prick amount of blood was collected on a Noviplex plasma card and stored at −80°C. Plasma cards and unstained tumor pathology slides were shipped regularly to US laboratories for NOHA, histologic and IHC analysis. NOHA and IHC assay operators were blinded to each other's result and patient clinical status. Paired NOHA and IHC results were compared. RESULTS Slides from 43 participants were available for pathological analysis in the United States. Of those with confirmed malignancy (n = 39), 44%, 51%, 5% were ER-positive, ER-negative, and ER inconclusive, respectively. NOHA levels were available among 33 of 43 of those with pathological data and showed distinct threshold levels correlating 100% to tumor ER IHC and disease categorization where a level below 4 nM, from 4 to 8 nM, and above 8 nM signified ER-negative, ER-positive, and no cancer, respectively. CONCLUSION The results are consistent with findings from US patients and suggest NOHA's clinical utility as an accessible IHC replacement in determining ER status among low-and middle-income country patients with breast cancer, promising to extend access to cost-efficient, available hormonal agents and improve outcomes.
Inflecting the French
Authors: Grand Pre Tyler 
Published: December 2022

Abstract
Aimé Césaire’s long poem Cahier d’un retour au pays natal is the most expressive example of his ambitious effort “infléchir le français” (“to inflect the French”), as he famously put it in an interview, “pour exprimer, dison: ce moi, ce moi-nègre, ce moi-créole, ce moi-martiniquais, ce moi-antillais” (translated by Brent Edwards, this reads: “in order to express, let’s say: “this I, this nègre-I, this creole-I, this Martinican-I, this Antillean-I”). Many scholars have read the Cahier’s inflection of French language and discourse in terms of its elaborate use of Latinate neologisms, archaic terminology, and typographic wordplay; however, less attention has been given to the implications this poem’s tortuous shifts in address have as a radical critique of the formal desires and ontological exclusions of Enlightenment universalism. Through the way Césaire rearticulates the basic components of grammatical address in a vexed, lyric encounter with the colonial reality of Martinique, he gradually recalibrates the relationship between the poem’s speaker and the African-diasporic community of and beyond Martinique as that between a kind of intersubjective voice of négritude and a globally discursive locus of anticolonialism—what he later calls the “rendez-vous de la conquête” (“convocation of conquest”).
ΤΑ ΧΗΜΙΚΑ ΣΤΟΙΧΕΙΑ ΤΩΝ ΚΙΝΗΤΩΝ ΤΗΛΕΦΩΝΩΝ
Authors: Konianos Ilias , Koutsoupia Marianna , Michailidis Marios , Pnagiotopoulos Panagiotis , Giallousi Maria 
Published: December 2022

Οι ερευνητικές εργασίες των μαθητών στο πλαίσιο του μαθήματος της Χημείας της Β΄ γυμνασίου, σχεδιάστηκαν και υλοποιήθηκαν με εναρκτήριο αντικείμενο μελέτης τα χημικά στοιχεία στα κινητά τηλέφωνα. Εφαρμόστηκε το μοντέλο της ενημερωμένης δράσης μέσω έρευνας στο διαδίκτυο και στην κοινότητα αλλά και η γνωστική στήριξη από την εκπαιδευτικό όπου ζητήθηκε. Η παρουσίαση της εργασίας στην τάξη αποσκοπούσε στην ευαισθητοποίηση των ομότιμων απέναντι σε θέματα ατομικής, κοινωνικής και περιβαλλοντικής ευημερίας που άπτονται του κύκλου ζωής των κινητών τηλεφώνων. Οι μαθητές αποτίμησαν την αναγκαιότητα της γνώσης πριν τη δράση, της δράσης για την ενίσχυση της ευαισθητοποίησης καθώς και του αυτοκατευθυνόμενου ακτιβισμού. Συντονισμένες προτάσεις προς αυτό τον προσανατολισμό θα βοηθήσουν τους μαθητές να κάνουν τη διαφορά στον κόσμο του 21ου αιώνα.
Η “βιομηχανία” της δωρεάς οργάνων
Authors: Nikolopoulos Konstantinos_Marios 
Published: December 2022

Η δωρεά οργάνων στην Ελλάδα βρίσκεται τα τελευταία χρόνια σε κρίση. Στην Ε.Ε κατέχει μία από τις τελευταίες θέσεις στις δωρεές οργάνων και ιστών. Άνθρωποι περιμένουν χρόνια για μια μεταμόσχευση και πολλοί πεθαίνουν στην αναμονή. Υπάρχει τεράστια έλλειψη προσωπικού ενώ δεν υπάρχουν κατάλληλες μονάδες για την μεταμόσχευση ορισμένων οργάνων με αποτέλεσμα οι Έλληνες να πρέπει να φεύγουν στο εξωτερικό.
Όλα τα παραπάνω έχουν ως αποτέλεσμα την τεράστια επιβάρυνση του Δημοσίου ύψους αρκετά άνω του μισού δισεκατομμυρίου για την περίθαλψη των ατόμων αυτών, χωρίς σε αυτό να υπολογίζονται και τα πιθανά χρήματα που θα μπορούσε να λαμβάνει ως φόρο από την εργασία των ατόμων αλλά και από την κατανάλωση αγαθών. Έτσι δημιουργείται η ανάγκη για να βρεθούν λύσεις πάνω στις οποίες θα μπορούσε να στηριχτεί ένα σύστημα, το οποίο σε βάθος χρόνων θα μπορέσει να μειώσει και ίσως να εξαλείψει το πρόβλημα.
Disparities in the prevalence of screened depression at different altitudes in Peru: A retrospective analysis of the ENDES 2019
Authors: Zegarra-Rodríguez Cynthia Alejandra , Plasencia-Dueñas Nahún Raphael , Failoc-Rojas Virgilio E. 
Published: December 2022

Introduction
Depression is a public health concern, nearing 1.5 million cases and accounting for 9.7% of years lost due to disability. Several factors, including altitude, contribute to its development. Altitude has become a topic for recent research, but its association with depressive symptoms has not been fully clarified. Therefore, this study aimed to determine the association between altitude and depressive symptoms in the Peruvian population.

Methods
A retrospective, cross-sectional study of the 2019 Demographic and Family Health Survey (ENDES in Spanish) was conducted. The dependent variable, depressive symptoms, was measured using the Patient Health Questionnaire (PHQ-9) and the independent variable, altitude, was categorized into: <1500 meters above sea level (masl), 1500–2499 masl and ≥2500 masl. To evaluate the association between altitude and depressive symptoms, we used Poisson regression model, constructing crude and multiple models.

Results
Of those living at 1500 to 2499 masl and ≥2500 masl, 7.23% and 7.12% had depressive symptoms, respectively. After adjusting for confounding variables, high altitude was found to be associated with depressive symptoms (prevalence ratio adjusted (aPR): 1.38, 95% confidence interval: 1.04–1.84; aPR 1.41, 95% CI: 1.20–1.66).

Conclusions
A statistically significant association was found between high altitude and depressive symptoms. This may be attributable to hypobaric hypoxia that occurs at high altitudes and its effects on brain function. This study’s findings should be considered to identify the population at risk and expand the coverage of preventive and therapeutic measures in high-altitude areas of Peru with poor access to health services.
Assessment of mouse VEGF neutralization by ranibizumab and aflibercept
Authors: Ichiyama Yusuke , Matsumoto Riko , Obata Shumpei , Sawada Osamu , Saishin Yoshitsugu , Kakinoki Masashi , Sawada Tomoko , Ohji Masahito 
Published: December 2022

Purpose
To assess the interaction between ranibizumab, aflibercept, and mouse vascular endothelial growth factor (VEGF), both in vivo and in vitro.

Methods
In vivo, the effect of intravitreal injection of ranibizumab and aflibercept on oxygen induced retinopathy (OIR) and the effect of multiple intraperitoneal injections of ranibizumab and aflibercept on neonatal mice were assessed. In vitro, the interaction of mouse VEGF-A with aflibercept or ranibizumab as the primary antibody was analyzed by Western blot.

Results
In both experiments using intravitreal injections in OIR mice and multiple intraperitoneal injections in neonatal mice, anti-VEGF effects were observed with aflibercept, but not with ranibizumab. Western blot analysis showed immunoreactive bands for mouse VEGF-A in the aflibercept-probed blot, but not in the ranibizumab-probed blot.

Conclusions
Aflibercept but not ranibizumab interacts with mouse VEGF, both in vivo and in vitro. When conducting experiments using anti-VEGF drugs in mice, aflibercept is suitable, but ranibizumab is not.
COVID-19 mortality may be reduced among fully vaccinated solid organ transplant recipients
Authors: Sandoval Micaela , Nguyen Duc T. , Huang Howard J. , Yi Stephanie G. , Ghobrial R. Mark , Gaber A. Osama , Graviss Edward A. 
Published: December 2022

Background
Solid organ transplant (SOT) recipients are at increased risk for morbidity and mortality from COVID-19 due to their immunosuppressed state and reduced immunogenicity from COVID-19 mRNA vaccines. This investigation examined the association between COVID-19 mRNA vaccination status and mortality among SOT recipients diagnosed with COVID-19.

Methods & findings
A retrospective, registry-based chart review was conducted investigating COVID-19 mortality among immunosuppressed solid organ transplant (SOT) recipients in a large metropolitan healthcare system in Houston, Texas, USA. Electronic health record data was collected from consecutive SOT recipients who received a diagnostic SARS-CoV-2 test between March 1, 2020, and October 1, 2021. The primary exposure was COVID-19 vaccination status at time of COVID-19 diagnosis. Patients were considered ‘fully vaccinated’ at fourteen days after completing their vaccine course. COVID-19 mortality within 60 days and intensive care unit admission within 30 days were primary and secondary endpoints, respectively. Among 646 SOT recipients who were diagnosed with COVID-19 at Houston Methodist Hospital between March 2020, and October 2021, 70 (10.8%) expired from COVID-19 within 60 days. Transplanted organs included 63 (9.8%) heart, 355 (55.0%) kidney, 108 (16.7%) liver, 70 (10.8%) lung, and 50 (7.7%) multi-organ. Increasing age was a risk factor for COVID-19 mortality, while vaccination within 180 days of COVID-19 diagnosis was protective in Cox proportional hazard models with hazard ratio 1.04 (95% CI: 1.01–1.06) and 0.31 (0.11–0.90), respectively). These findings were confirmed in the propensity score matched cohort between vaccinated and unvaccinated patients.

Conclusions
This investigation found COVID-19 mortality may be significantly reduced among immunosuppressed SOT recipients within 6 months following vaccination. These findings can inform vaccination policies targeting immunosuppressed populations worldwide.
Self-managed physical activity in cancer survivors for the management of cancer-related fatigue: A scoping review
Authors: Campanini Isabella , Ligabue Maria Bernadette , Bò Maria Chiara , Bassi Maria Chiara , Lusuardi Mirco , Merlo Andrea 
Published: December 2022

Objective
Cancer-related fatigue (CRF) is a disabling chronic condition that cancer survivors could experience during and after recovery and that might benefit from self-managed physical activity (PA) programs. This scoping review aimed to map self-managed PA interventions found in literature for the management of CRF.

Methods
Given the heterogeneity of the topic, scoping review methodological frameworks were used. Pubmed, Cinahl and Cochrane databases were searched for primary literature. Inclusion criteria: self-managed PA meant as any exercise program prescribed by a professional either with or without initial supervision and training which then continued independently for a given time frame; patient-reported fatigue assessment included in the outcome measures. Articles dealing with entirely supervised interventions, dietary or psychological-only therapies, and with palliative care were excluded.

Results
Of the 543 experimental or observational studies screened, 63 were included. Of these forty-three studies were randomized controlled trials. Data were summarized in tables describing self-managed interventions according to: type of self-managed activity, frequency and duration, strategies to promote adherence, professionals supervising the treatment, outcome measures, and efficacy. A narrative synthesis was also added to further explain findings.

Conclusions
We collected the available evidence on PA when this was self-managed by patients after prescription by a healthcare provider. Clinicians and researchers should consider incorporating self-care programs in CRF patients’ recovery journey gradually, identifying the best strategies to integrate them into daily life. Researchers should specify the characteristics of PA programs when designing new studies. This review highlighted the areas to be investigated for future studies pertaining to self-managed PA.
Survival status and predictors of mortality among asphyxiated neonates admitted to the NICU of Dessie comprehensive specialized hospital, Amhara region, Northeast Ethiopia
Authors: Yitayew Yibeltal Asmamaw , Yalew Zemen Mengesha 
Published: December 2022

Introduction
Birth asphyxia is one of the leading causes of early neonatal mortality, which causes an estimated 900,000 deaths annually. Therefore, assessing the survival status and predictors of mortality among asphyxiated neonates will be highly helpful to policymakers in designing, implementing, and evaluating programs to achieve the sustainable development goal of reducing neonatal mortality as low as 12/1,000 live births by 2030.

Methods
A facility-based retrospective cohort study was conducted among 378 asphyxiated neonates admitted to the NICU of Dessie Comprehensive Specialized Hospital from January, 2017 –December, 2019. The data were collected from eligible records by using a structured data extraction tool from March 30 –April 21, 2020. The data were cleaned manually and entered into Epi-data version 7.1.2.0, and STATA version 16 was used for the analysis. Bivariate and Multivariate Cox proportional hazard regression analysis were performed, and significant predictors were identified using 95% confidence interval and p-value <0.05.

Result
A total of 378 neonates were followed for 2298 neonatal days, ranging from 1 to 28 days. The mortality incidence rate was 5.3/100 person-days-of observation (95% CI: 4.41, 6.29), and 32% (95% CI: 27.6%, 36.8%) of the study subjects died. Admission weight (AHR: 1.72; 95% CI: 1.09, 2.72), seizure (AHR: 1.52; 95% CI: 1.02, 2.27), neonates who received resuscitation (AHR: 2.11; 95% CI: 1.18, 3.80), and stage of asphyxia (moderate (AHR: 3.50; 95% CI: 1.55, 8.36), and severe (AHR: 11.55; 95% CI: 4.73, 28.25)) were significant predictors of neonatal mortality among asphyxiated neonates.

Conclusion
The magnitude of neonatal mortality among asphyxiated neonates in the study area was high. Admission weight, seizure, resuscitation, and stage of asphyxia were significant predictors of mortality among neonates with asphyxia. Therefore, special attention should be given to asphyxiated neonates with low admission weight and those who had seizure. Additionally, the timing, quality, and effectiveness of resuscitation might need further assessment and evaluation.
A multiomics analysis of direct interkingdom dynamics between influenza A virus and Streptococcus pneumoniae uncovers host-independent changes to bacterial virulence fitness
Authors: Platt Maryann P. , Lin Yi-Han , Penix Trevor , Wiscovitch-Russo Rosana , Vashee Isha , Mares Chris A. , Rosch Jason W. , Yu Yanbao , Gonzalez-Juarbe Norberto 
Published: December 2022

Background
For almost a century, it has been recognized that influenza A virus (IAV) infection can promote the development of secondary bacterial infections (SBI) mainly caused by Streptococcus pneumoniae (Spn). Recent observations have shown that IAV is able to directly bind to the surface of Spn. To gain a foundational understanding of how direct IAV-Spn interaction alters bacterial biological fitness we employed combinatorial multiomic and molecular approaches.

Results
Here we show IAV significantly remodels the global transcriptome, proteome and phosphoproteome profiles of Spn independently of host effectors. We identified Spn surface proteins that interact with IAV proteins (hemagglutinin, nucleoprotein, and neuraminidase). In addition, IAV was found to directly modulate expression of Spn virulence determinants such as pneumococcal surface protein A, pneumolysin, and factors associated with antimicrobial resistance among many others. Metabolic pathways were significantly altered leading to changes in Spn growth rate. IAV was also found to drive Spn capsule shedding and the release of pneumococcal surface proteins. Released proteins were found to be involved in evasion of innate immune responses and actively reduced human complement hemolytic and opsonizing activity. IAV also led to phosphorylation changes in Spn proteins associated with metabolism and bacterial virulence. Validation of proteomic data showed significant changes in Spn galactose and glucose metabolism. Furthermore, supplementation with galactose rescued bacterial growth and promoted bacterial invasion, while glucose supplementation led to enhanced pneumolysin production and lung cell apoptosis.

Conclusions
Here we demonstrate that IAV can directly modulate Spn biology without the requirement of host effectors and support the notion that inter-kingdom interactions between human viruses and commensal pathobionts can promote bacterial pathogenesis and microbiome dysbiosis.
Investigação das propriedades do concreto convencional com adição da fibra de bambu e da substituição parcial do cimento pelo Metacaulim
Authors: Ribeiro Vander Alkmin dos Santos , Barbosa Luciano Floriano , Oliveira Adhimar Flávio , Paiva Bruno Nannetti Dias , Dos Santos Valquíria Claret , Silva João Lucas Pereira da Silva da 
Published: December 2022

O trabalho presente tem como um objetivo geral a investigação das propriedades físicas e mecânicas do concreto convencional com substituição metacaulim e adição de fibra de bambu. O uso do bambu pela humanidade é feito desde os primórdios sendo utilizado em diversas ocasiões, desde uso alimentício até o uso de peças estruturais para construções de moradias, e sua adição no concreto convencional torna-se um grande atrativo para pesquisadores e engenheiros. Apesar dos estudos do implemento de metacaulim no concreto serem hodiernos, em relação ao implemento de outros materiais minerais, seu uso como material pozolânico antecede o uso de cimento, atualmente com o desenvolvimento da humanidade, as construções vêm crescendo a cada dia e com características de maior porte, assim, o consumo de cimento cresce rigorosamente e a produção de uma tonelada de cimento é gerada em torno de 0,8 toneladas de CO2 na atmosfera. Nos últimos anos os houve um grande esforço na área de caracterização e desenvolvimento para oferecer materiais mais resistentes e duráveis no campo da engenharia, várias razões têm motivado a procura por materiais, de origem pozolânica, para a substituição parcial do cimento Portland na produção de concreto e o metacaulim representa uma solução economicamente viável para a substituição parcial ou total do cimento na confecção de concreto. Os materiais utilizados para confecção do concreto foram caracterizados para elaboração dos traços pelo método ABCP-ACI. Os corpos de prova foram confeccionados e ensaiados com substituição parcial de cimento por metacaulim e adição de bambu e os resultados mostraram uma queda significativa nas resistências mecânicas do concreto.