bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enlarged housing space and increased spatial complexity enhance hippocampal neurogenesis but do not increase physical activity in mice
Authors: Funabashi Daisuke , Tsuchida Ryuki , Matsui Takashi , Kita Ichiro , Nishijima Takeshi 
Published: September 2023

IntroductionEnvironmental enrichment (EE) improves various health outcomes, such as hippocampal neurogenesis, in rodents, which is thought to be caused, in part, by increased physical activity. However, the specific effect of each enrichment component, such as enlarged housing spaces and increased spatial complexity with a variety of objects, on physical activity remains unclear because of methodological limitations in measuring physical activity. We aimed to examine whether enlarged housing spaces and increased spatial complexity increase physical activity in mice using a body-implantable actimeter.MethodsAdult male C57BL/6J mice were assigned to either standard housing or EE groups. The housing environment in the EE mice was gradually enriched by enlarging the housing space and the placement of a variety of objects. Physical activity was measured using a body-implanted actimeter. Hippocampal neurogenesis was immunohistochemically examined.ResultsEnlarged housing spaces and the placement of a variety of objects did not increase physical activity in mice. In contrast, hippocampal neurogenesis was enhanced in the EE mice, suggesting that environmental interventions successfully provided enriched housing conditions for these mice.ConclusionsThese results indicate that enlarged housing spaces and increased spatial complexity do not increase physical activity in mice. Furthermore, we found that EE enhanced hippocampal neurogenesis without increasing activity volume. Besides the current understanding that increasing the amount of physical activity is key to improving hippocampal function, our result suggests that the environment in which physical activity takes place is also a crucial contextual factor in determining the impact of physical activity on hippocampal function.
The Effects of Flavonol and Flavone Glucuronides from Potentilla chinensis Leaves on TNF-α-Exposed Normal Human Dermal Fibroblasts
Authors: Choi Yea Jung , Lee So Young , Son So-Ri , Park Jun Yeon , Jang Dae Sik , Lee Sullim 
Published: September 2023

Skin aging is a complex biological process influenced by a variety of factors, including UV radiation. UV radiation accelerates collagen degradation via the production of reactive oxygen species (ROS) and cytokines, including TNF-α. In a prior investigation, the inhibitory properties of flavonol and flavone glucuronides derived from Potentilla chinensis on TNF-α-induced ROS and MMP-1 production were explored. Consequently, we verified the skin-protective effects of these flavonol and flavone glucuronides, including potentilloside A, from P. chinensis, and conducted a structure–activity relationship analysis as part of our ongoing research. We investigated the protective effects of the extract and its 11 isolates on TNF-α-stimulated normal human dermal fibroblasts (NHDFs). Ten flavonol and flavone glucuronides significantly inhibited ROS generation (except for 7) and suppressed MMP-1 secretion, except for 2. In contrast, six isolates (1, 5, 6, 11, 9, 10, and 11) showed a significant reverse effect on COLIA1 secretion. Comparing the three experimental results of each isolate, potentilloside A (1) showed the most potent skin cell-protective effect among the isolates. Evaluation of the signaling pathway of potentilloside A in TNF-α-stimulated NHDF revealed that potentilloside A inhibits the phosphorylation of ERK, JNK, and c-Jun. Taken together, these results suggest that compounds isolated from P. chinensis, especially potentilloside A, can be used to inhibit skin damage, including aging.
KDM2A Deficiency in the Liver Promotes Abnormal Liver Function and Potential Liver Damage
Authors: Martin Matthew , Motolani Aishat , Kim Hyeong-Geug , Collins Amy M. , Alipourgivi Faranak , Jin Jiamin , Wei Han , Wood Barry A. , Ma Yao-Ying , Dong X. Charlie , Mirmira Raghavendra G. , Lu Tao 
Published: September 2023

Dysregulation of metabolic functions in the liver impacts the development of diabetes and metabolic disorders. Normal liver function can be compromised by increased inflammation via the activation of signaling such as nuclear factor (NF)-κB signaling. Notably, we have previously identified lysine demethylase 2A (KDM2A)—as a critical negative regulator of NF-κB. However, there are no studies demonstrating the effect of KDM2A on liver function. Here, we established a novel liver-specific Kdm2a knockout mouse model to evaluate KDM2A’s role in liver functions. An inducible hepatic deletion of Kdm2a, Alb-Cre-Kdm2afl/fl (Kdm2a KO), was generated by crossing the Kdm2a floxed mice (Kdm2afl/fl) we established with commercial albumin-Cre transgenic mice (B6.Cg-Tg(Alb-cre)21Mgn/J). We show that under a normal diet, Kdm2a KO mice exhibited increased serum alanine aminotransferase (ALT) activity, L-type triglycerides (TG) levels, and liver glycogen levels vs. WT (Kdm2afl/fl) animals. These changes were further enhanced in Kdm2a liver KO mice in high-fat diet (HFD) conditions. We also observed a significant increase in NF-κB target gene expression in Kdm2a liver KO mice under HFD conditions. Similarly, the KO mice exhibited increased immune cell infiltration. Collectively, these data suggest liver-specific KDM2A deficiency may enhance inflammation in the liver, potentially through NF-κB activation, and lead to liver dysfunction. Our study also suggests that the established Kdm2afl/fl mouse model may serve as a powerful tool for studying liver-related metabolic diseases.
Palladium Iodide Catalyzed Multicomponent Carbonylative Synthesis of 2-(4-Acylfuran-2-yl)acetamides
Authors: Ziccarelli Ida , Veltri Lucia , Prestia Tommaso , Amuso Roberta , Chiacchio Maria A. , Mancuso Raffaella , Gabriele Bartolo 
Published: September 2023

2-Propargyl-1,3-dicarbonyl compounds have been carbonylated under oxidative conditions and with the catalysis of the PdI2/KI catalytic system to selectively afford previously unreported 2-(4-acylfuran-2-yl)acetamides in fair to good yields (54–81%) over 19 examples. The process takes place under relatively mild conditions and occurs via a mechanistic pathway involving Csp-H activation by oxidative monoamincarbonylation of the terminal triple bond of the substrates with formation of 2-ynamide intermediates, followed by 5-exo-dig O-cyclization (via intramolecular conjugate addition of the in situ formed enolate to the 2-ynamide moiety) and aromative isomerization.
Bilateral chronic subdural hematoma: clinical presentation, outcome and review literature.
Authors: Kaushal Yadav , Gaurav Jaiswal , Krishna Govind Lodha , Tarun Kumar Gupta , Pratik Bipinbhai Patel , Suresh Kumawat 
Published: September 2023

Study design: Prospective hospital-based study.
Background: Annual incidence of bilateral chronic subdural hematoma (CSDH) is increasing due to an increase in the ageing population, associated medical comorbidities such as haemodialysis, anticoagulant and/or antiplatelet therapy.
Objectives: 1. To determine the socio-demographic and clinical profile of bilateral CSDH patients. 2. To determine treatment outcome and its association with the socio-demographic profile.
Method: A prospective hospital-based study was carried out on 100 confirmed patients of bilateral CSDH. Information of patients such as socio-demographic profile, clinical presentation and laboratory investigation, along with treatment and outcome were recorded and analysed.
Results: Among 100 patients, male and female were 74% and 26%. The mean age of patients was 63.03±13.57 years. A history of head injury was reported by 49% of patients. The mean Glasgow coma scale (GCS) was 12.14±2.38. Common presenting symptoms were hemiparesis (69%), headache (58%), aphasia (18%) and complete loss of consciousness (16%). Clinical improvement was observed in 81% while 09% had no change, 06% shows clinical deterioration and 04% of patients die during treatment.
Conclusion: Bilateral CSDH is common in the elderly and prognosis is poor with increasing age however gender has no association with poor outcomes. More than 80% of patients recover with timely interventions.
Key message: Surgery leads to achieving good outcomes in cases of bilateral chronic SDH, but not all such patients will recover completely. Similarly, good functional outcomes can also be achieved in those presented early after symptom onset when managed promptly.
Cerebello Pontine Angle Hemangiopericytoma - an aggressive tumour needs aggressive management
Authors: Verma Abhijit , Gupta Vijay Kumar , Attry Sanjeev , Siddiqi Qamar , Singhavi Shashi 
Published: September 2023

Background: CP angle Hemangiopericytoma are rare tumors. Pre-operative suspicion and gross total excision are key for better management due to their aggressive nature.
Case presentation: 18-year-old male presented with signs of progressive brainstem compression. Contrast MRI showed a polycystic enhancing SOL in the right CP angle region compressing the brain stem and cerebellar lobe. Operated with histopathology and IHC indicating it to be a Hemangiopericytoma.
Conclusions: Hemangiopericytoma being an aggressive tumour with a high rate of recurrence compared to other common tumours at CP angle, complete resection with definitive pathological diagnosis and radiotherapy are needed for a better outcome.
Cerebrospinal fluid leak after combat penetrating gunshot wound to the head
Authors: Perekopaiko Yurii 
Published: September 2023

Introduction: Cerebrospinal fluid leak is a common complication after head gunshot wounds, which commonly leads to infectious complications. This complication may prolong hospital staying and prevents soldiers from return to operation theatre as soon as possible.
The purpose of this article is to determine the impact of the quality of primary surgical debridement and other factors that influenced the presence of cerebrospinal fluid leak in the military stuff with gunshot wounds to the head.
Materials and methods: This is a retrospective study of 20 military cases with cerebrospinal fluid leak, which were admitted during the combat actions in Eastern Ukraine in the period from March 2014 to the end of December 2017. Information was collected on demographics, evacuation assistance, type of injury and infectious complications. R commander version 4.2.0 (http://www.r-project.org) was used for statistical analysis. Statistical significance was defined as p<0.05.
Results: Cerebrospinal fluid fistulas were detected in 20 cases (25,31%). Factors affecting the rate of leaks are number of re-operations (p<0.001), multiple sites of injury (p=0.002), ventricular injury (p<0.005). CSF leakage significantly lengthens hospitalization time.
Conclusions: CSF fistula influenced significantly rate of infection complication. Reoperation should follow initial surgery in cases of CSF leak development. To avoid development of cerebrospinal fluid fistulas, the operation should be performed by neurosurgeons in specialized department.
The challenges and opportunities of patient safety culture in neurosurgical departments from the Republic of Moldova
Authors: Danu Silvia 
Published: September 2023

Neurosurgery is a high-risk speciality, so the Patient Safety Culture should become a priority to improve patient safety and the quality of medical care. The purpose of the study was to explore the perception of Patient Safety Culture (PSC) among the staff in the neurosurgical departments of the Republic of Moldova.
A cross-sectional study was conducted in neurosurgical departments using the Hospital Survey on Patient Safety Culture (HSOPSC). Descriptive statistics were carried out, comprising the Cronbach "?" coefficient, frequency of positive answers (PPRs), and level of minimum and maximum of 95% confidential interval. PPRs by question and dimension were analysed overall and classified according to the Harrington scale.
Medical staff from five hospitals voluntarily participated in the study. Most of the respondents rated the patient's safety grade as excellent and very good. The value of the frequency of positive responses to the dimensions of the survey varies between 37.3% (nonpunitive response to error) and 85.0% (teamwork within units). The dimensions with the highest score of the PPRs stand out: „teamwork within units”, „organizational learning- continuous improvement” and „supervisor/manager expectations and actions promoting patient safety”. The dimension with a high score of PPRs was „feedback and communication about error”. The dimensions with a satisfactory score of the PPRs were „handoffs and transitions”, „frequency of events reported”, „management support for patient safety”, „teamwork across units”, „communication openness”, „overall perceptions on patient safety”, „non-punitive response to errors” and „staffing”.
For the first time in the Republic of Moldova, the perception of patient safety culture in neurosurgery departments was studied. The results reflect the positive attitude of the staff towards most dimensions of the patient safety culture. The study made it possible to highlight the strong and vulnerable points of the patient safety culture in neurosurgical departments from Moldova.
L'altérité juive dans la pensée espagnole 1550-1650
Authors: Méchoulan Henry 
Published: September 2023

L'étude de l'altérité juive a une double finalité. Rendre compte d'abord de l'importance de l'obsession raciste dans la pensée philosophique, médicale, juridique espagnole entre 1550 et 1650. Dans ce domaine, on a mis en lumière, à quelques exceptions près, que le savoir se trahit en devenant le reflet de l'opinion dont on connaît la frénésie raciste.
Mais ensuite, on a voulu montrer un aspect moins connu de la pensée espagnole. C'est pourquoi cette étude s'est attachée à présenter les conséquences morales et politiques des délires de cette passion qui déterminent un retour vers une lucidité, un «desengaño», et une double moralité. Celle-ci abritera un universalisme cosmopolite issu du retour vers un stoïcisme authentique, engendrant des méditations hardies et hétérodoxes qui n'excluent pas une condamnation, le plus souvent implicite mais parfois explicite, du racisme.
Vérité prophétique et vérité philosophique chez Nissim de Gérone. Une interprétation du «Récit de la Création» et du «Récit du Char»
Authors: Klein-braslavy Sara 
Published: September 2023

Dans cet article nous voulons démontrer que R. Nissim de Gérone adopte les vues d'Isaac Albalag touchant les rapports entre la religion et la philosophie : la vérité prophétique et la vérité philosophique sont deux vérités distinctes et chacune est appré¬ hendée par un mode de connaissance qui lui est particulier. La vérité prophétique est appréhendée à la faveur d'un «épanche-ment divino-prophétique », par une connaissance a priori, c'est-à-dire une démarche de cause à effet ; la vérité philosophique est appréhendée par «recherche », par une connaissance a posteriori, c'est-à-dire une progression de l'effet à la cause.
R. Nissim développe cette vue fondamentale élucidant le sens des concepts «œuvre de la création » et «vision du char divin ». Il critique l'identification posée par Maïmonide entre «l'œuvre de la création » et la Physique d'Aristote d'une part, et la «vision du char divin » et la Métaphysique d'autre part, et précise que ces sciences étant ésotériques ne peuvent être que basées sur la connaissance prophétique et non sur la connaissance philosophique. R. Nissim fixe le domaine de 1'«œuvre de la création » et de la «vision du char divin » par l'analyse de la connaissance intellec¬ tuelle possible dans ce bas-monde et en précise les limitations. Ici, il est influencé, comme on peut le constater, par des principes épistémologiques en vogue — dans la littérature médicale entre autres — de la théorie sémiologique qui remonte aux stoïciens et aux épicuriens, et aussi par les théories de R. Juda Halévi et d'Albalag quant au problème de la limitation de la connaissance philosophique et du caractère des connaissances prophétique et divine. L'«œuvre de la création » est, selon lui, une explication du rapport causal entre les différents intellects et les formes des choses dans ce monde, et entre ces formes et les actions qui en dérivent ; alors que le «char divin » est la connaissance de la manière dont s'enchaînent les différents intellects à partir de Dieu.
La critique par R. Nissim de l'interprétation maïmonidienne des concepts d'«œuvre de la création » et de «vision du char divin » a influencé son disciple Hasday Crescas qui charge ces concepts de significations mystiques.
Vivência em estágio extracurricular voluntário em unidades básicas de saúde no município de Coari - AM: um relato de experiência
Authors: Oliveira Vivian Graziella dos Santos , Gonçalves Letícia Kelly Cristina Braga da Cruz , Da Silva Rosimary Lima , De Souza Dhienifã Brena Marinho 
Published: September 2023

Relatar a vivência de acadêmicas da Universidade Federal do Amazonas em um estágio extracurricular de enfermagem em unidades básicas de saúde do município de Coari-AM. Trata-se de um estudo descritivo, de natureza relato de experiência, realizado através da vivência das acadêmicas do curso de enfermagem da Universidade Federal do Amazonas, durante estágio extracurricular voluntário realizado em duas Unidades Básicas de Saúde, no município de Coari-AM. Durante o estágio, foi dada às acadêmicas total autonomia para exercer as funções que são encarregadas do profissional de enfermagem da atenção básica, como: realização de coletas de preventivo, consultas de pré-natal, visitas domiciliares, participação em campanhas de vacinação, curativos, realização de testes rápidos, atividades de educação em saúde para a população e consultas de enfermagem. Com esta experiência, foi possível observar com ainda mais clareza a tamanha importância do enfermeiro para o bom funcionamento da Unidade Básica de Saúde, pois é ele quem rege toda a sua estrutura, comanda a equipe e conhece as famílias e as principais necessidades daquela unidade. As atividades desenvolvidas no estágio permitiram o fortalecimento do conhecimento prático de enfermagem na atenção básica, além de enriquecer o currículo das acadêmicas que o realizaram, tornando-se assim, uma experiência enriquecedora e muito valorosa.
THE EFFECT OF PROFITABILITY AND LIQUIDITY ON COMPANY VALUE (Case Study of Banking Company on IDX 2014-2018)
Authors: Jamiah  
Published: September 2023

The development of the business world has grown rapidly, both large-scale companies and This research illustrates that the distribution of data that is a reference in the research is indicated not to be distributed correctly, because in the recapitulation of the annual financial report there are several companies that do not present complete financial statement items, this affects the analysis of processed data, small scale, one of which is to list the company on the Stock Exchange Indonesia, The purpose of this study is to determine the Effect of Profitability and Liquidity on Company Value (Case Study of Banking Companies on the Indonesia Stock Exchange 2014-2018). This study used a descriptive quantitative approach. The research sample used was 19 companies that had met the criteria that had been set with the Nonprobability sampling method with purposive sampling techniques. The results showed that the profitability variable had no effect on the Company Value It can be seen from the value of the coefficient of 0.233 and t count of 1.202 with a significance of 0.233 > 0.05 (greater than 0.05) while liquidity has no effect on the value of the company, seen from the efficiency value of -0.131 and t count of -1.152 with a significance of 0.253 > 0.05 (greater than 0.05)
Keywords: Profitability; Liquidity; Company Value ; Banking; IDX
EFFECTS OF AGE ON GROWTH, COMPOSITIONS AND QUALITY ATTRIBUTES OF CHEVON FROM WEST AFRICAN DWARF (GOATS) BUCKS
Authors: Ayanniyi N. N. , Adeyemi S. A. , Eze J. N. , Aliyu E. J. , Orimogunje A. D. 
Published: September 2023

Abstract
Fifty-six growing bucks purchased from different farmers in Oyo and Osun States were used to carry out the study. The animals were weighed and disinfected against both ecto and endo parasites before the start of the experiment. The average weights at purchased ranged between 7.67 and 9.86kg and the experiment laid out in a Complete Randomized Design (CRD). The ages of the bucks were identified and determined using appearance of the incisors and were grouped accordingly. Final Body Weight (FBW), Average Daily Weight gain, (ADWG) and Feed Conversion Ratio, (FCR) were determined using standard procedures. Dressing percentage (DP), Shear Forces (SF), Rib eye area, (REA) and Water holding capacity, (WHC) were evaluated after three bucks per treatments were sacrificed. Also evaluated were percentage proportion of lean, bone and fat. Results showed that the average weights at slaughter were 13.47kg, 16.09 and 20.35kg at 12, 18 and 24 months respectively. However the shear forces of 4.97kg/cm and 5.01kg/cm at 18 and 24 months old bucks were similar and significantly higher than that of yearling goats (2.66 kg/cm). The TFD and MBR also varied significantly as the age. The study concluded that older animals produced carcasses with higher total fat deposits, more meat and but relatively less GI tract contents compared with others. The study recommended however that the cost of managing the animals within a time taken, feed consumptions including medications to reach the 24 month could be economically evaluated to justify the need for the added time.
Faktor-Faktor yang Berhubungan dengan Pernikahan Dini di Desa Kebon IX Kecamatan Sungai Gelam Muaro Jambi Tahun 2022
Authors: Wulandari Diana , Haryanti Dwi 
Published: September 2023

Early marriage is a marriage under the age that should not be ready for marriage. The age limit for marriage is 20 years for women and 25 years for men. The purpose of this study was to determine the factors associated with early marriage in Kebon IX village, Muaro Jambi. This research is an analytic research type with a cross sectional design which in this study studies the relationship between risk factors and disease (effect), observations or measurements of the independent variable (risk factor) and dependent variable (effect) are carried out once and at the same time. The variables studied were knowledge, parental income level, education and parental belief in early marriage, population 33 people, research sample 33 people. The source of data in this study is primary data, data obtained through questionnaires used by Bivariate and Univariate analysts. The results showed that there was a relationship between knowledge and early marriage (p-value = 0.000 0.05), parents' income level (p-value = 0.001 0.05), education level (p-value = 0.000 0, 05), and the level of parental confidence (p-value = 0.003 0.05).