bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial intelligence and bioinformatics analyze markers of children's transcriptional genome to predict autism spectrum disorder
Authors: Tang Huitao , Liang Jiawei , Chai Keping , Gu Huaqian , Ye Weiping , Cao Panlong , Chen Shufang , Shen Daojiang 
Published: July 2023

IntroductionAutism spectrum disorder (ASD), characterized by difficulties in social interaction and communication as well as restricted interests and repetitive behaviors, is extremely challenging to diagnose in toddlers. Early diagnosis and intervention are crucial however.MethodsIn this study, we developed a machine learning classification model based on mRNA expression data from the peripheral blood of 128 toddlers with ASD and 126 controls. Differentially expressed genes (DEGs) between ASD and controls were identified.ResultsWe identified genes such as UBE4B, SPATA2 and RBM3 as DEGs, mainly involved in immune-related pathways. 21 genes were screened as key biomarkers using LASSO regression, yielding an accuracy of 86%. A neural network model based on these 21 genes achieved an AUC of 0.88.DiscussionOur findings suggest that the identified neurotransmitters and 21 immune-related biomarkers may facilitate the early diagnosis of ASD. The mRNA expression profile sheds light on the biological underpinnings of ASD in toddlers and potential biomarkers for early identification. Nevertheless, larger samples are needed to validate these biomarkers.
A study on the correlations between acoustic speech variables and bradykinesia in advanced Parkinson's disease
Authors: Cavallieri Francesco , Di Rauso Giulia , Gessani Annalisa , Budriesi Carla , Fioravanti Valentina , Contardi Sara , Menozzi Elisa , Pinto Serge , Moro Elena , Antonelli Francesca , Valzania Franco 
Published: July 2023

BackgroundVery few studies have assessed the presence of a possible correlation between speech variables and limb bradykinesia in patients with Parkinson's disease (PD). The objective of this study was to find correlations between different speech variables and upper extremity bradykinesia under different medication conditions in advanced PD patients.MethodsRetrospective data were collected from a cohort of advanced PD patients before and after an acute levodopa challenge. Each patient was assessed with a perceptual-acoustic analysis of speech, which included several quantitative parameters [i.e., maximum phonation time (MPT) and intensity (dB)]; the Unified Parkinson's Disease Rating Scale (UPDRS) (total scores, subscores, and items); and a timed test (a tapping test for 20 s) to quantify upper extremity bradykinesia. Pearson's correlation coefficient was applied to find correlations between the different speech variables and the tapping rate.ResultsA total of 53 PD patients [men: 34; disease duration: 10.66 (SD 4.37) years; age at PD onset: 49.81 years (SD 6.12)] were included. Levodopa intake increased the MPT of sustained phonation (p &lt; 0.01), but it reduced the speech rate (p = 0.05). In the defined-OFF condition, MPT of sustained phonation positively correlated with both bilateral mean (p = 0.044, r-value:0.299) and left (p = 0.033, r-value:0.314) tapping. In the defined-ON condition, the MPT correlated positively with bilateral mean tapping (p = 0.003), left tapping (p = 0.003), and right tapping (p = 0.008).ConclusionThis study confirms the presence of correlations between speech acoustic variables and upper extremity bradykinesia in advanced PD patients. These findings suggest common pathophysiological mechanisms.
Physiological-induced conductive response evaluation in specific muscle compartments under hybrid of electrical muscle stimulation and voluntary resistance training by electrical impedance tomography
Authors: Sun Bo , Darma Panji Nursetia , Sejati Prima Asmara , Shirai Tomoyuki , Narita Kosei , Takei Masahiro 
Published: July 2023

Objective: The physiological-induced conductive response has been visualised for evaluation in specific muscle compartments under hybrid (hybridEMS) of electrical muscle stimulation (EMS) and voluntary resistance training (VRT) by electrical impedance tomography (EIT).Methods: In the experiments, tendency of conductivity distribution images σ over time was clearly detected for three specific muscle compartments, which are called AM1 compartment composed of biceps brachii muscle, AM2 compartment composed of triceps brachii muscle, and AM3 compartment composed of brachialis muscle, under three training modalities.Results: From the experimental results, the tendency of physiological-induced conductive response are increased in all three training modalities with increasing training time. Correspondingly, the spatial-mean conductivity &lt;σ&gt;AM1,AM2,AM3 increased with the conductance value G and extracellular water ratio β of right arm by bio-impedance analysis (BIA) method. In addition, hybridEMS has the greatest effect on physiological-induced conductive response in AM1, AM2, and AM3. Under hybridEMS, the spatial-mean conductivity increased from &lt;σpre &gt; AM1 = 0.154 to &lt;σ23mins &gt; AM1 = 0.810 in AM1 muscle compartment (n = 8, p &lt; 0.001); &lt;σpre &gt; AM2 = 0.040 to &lt;σ23mins &gt; AM2 = 0.254 in AM2 muscle compartment (n = 8, p &lt; 0.05); &lt;σpre &gt; AM3 = 0.078 to &lt;σ23mins &gt; AM3 = 0.497 in AM3 muscle compartment (n = 8, p &lt; 0.05).Conclusion: The paired-samples t-test results of &lt;σ&gt;AM1,AM2,AM3 under all three training modalities suggest hybridEMS has the most efficient elicitation on physiological induced conductive response compared to VRT and EMS. The effect of EMS on deep muscle compartment (AM3) is slower compared to VRT and hybridEMS, with a significant difference after 15 min of training.
Kidney and Cancer Outcomes with Standard Versus Alternative Chemotherapy Regimens for First-Line Treatment of Metastatic Urothelial Carcinoma
Authors: Côté Gabrielle , Alqaisi Husam , Chan Christopher T , Jiang Di Maria , Kandel Christopher , Pelletier Karyne , Wald Ron , Sridhar Srikala S. , Kitchlu Abhijat 
Published: July 2023

Key Points

Many patients with metastatic urothelial carcinoma are deemed cisplatin-ineligible because of reduced kidney function. Options include split-dose cisplatin or carboplatin.There was no significant association between regimen type and AKI. Alternative regimens were associated with higher risk of progressive disease.There is a need to revisit cisplatin eligibility criteria and develop strategies to optimize cancer treatment for patients with CKD.

Background
Cisplatin-based chemotherapy regimens remain the optimal first-line treatment for patients with metastatic urothelial carcinoma (mUC). However, many patients are deemed cisplatin-ineligible, predominantly because of reduced kidney function. Other treatment options include split-dose cisplatin, carboplatin, and non–platinum-based regimens. We compared the incidence of AKI and cancer outcomes within three chemotherapy regimens.

Methods
We conducted a single-center retrospective study of patients with mUC who received first-line chemotherapy from 2005 to 2019. We compared standard gemcitabine–cisplatin (gem-cis) with two alternative regimens: (1) gem-cis split-dose regimen (split) with cisplatin divided over days 1 and 8 and (2) combination of gemcitabine–carboplatin or single-agent gemcitabine (gem/gem-carbo). The primary outcome was Kidney Disease Improving Global Outcomes–defined AKI. Secondary outcomes included overall survival and progression-free survival.

Results
We identified 183 patients (98 gem-cis, 32 split, and 53 gem/gem-carbo). Median baseline eGFR in the gem/cis group was 78 ml/min per 1.73 m2 (interquartile range, 66–91), in the split group 64 (48–77), and in the gem/gem-carbo 45 (33–57). There was no significant association between regimen type and incidence of AKI when adjusted for age, Eastern Cooperative Oncology Group, baseline eGFR, hypertension, diabetes, and visceral disease. The adjusted hazard ratios were 1.31 (95% confidence interval [CI], 0.61 to 2.78; P = 0.49) and 0.98 (95% CI, 0.46 to 2.07; P = 0.95) for split and gem/gem-carbo groups, respectively, versus gem-cis. Split and gem/gem-carbo regimens were associated with higher mortality and progressive disease relative to gem-cis with an adjusted hazard ratio of 1.54 (95% CI, 1.02 to 2.33; P = 0.04) and 1.96 (95% CI, 1.31 to 2.95; P < 0.01), respectively. Median progression free survival was 8.1 (interquartile range, 4.6–14.8), 6.1 (4.1–9.3), and 4.4 (2.3–8.6) months in the gem-cis, split, and gem/gem-carbo groups.

Conclusions
There was no significant difference in the incidence of AKI between the three regimens studied. However, standard gem-cis was associated with improved cancer outcomes. Novel regimens and kidney protective strategies are needed for patients with mUC with kidney disease.
Pementasan Musik Genggong di Desa Batuan Kabupaten Gianyar
Authors: Saputra I Kadek Bharata Dwyq , Temon Astawa I Nyoman , Sukerni Ni Made 
Published: July 2023

Bali is known for its arts, culture, and traditions because every tradition and culture is always based on Hinduism and does not leave the local culture that already exists in the area. One of them is the performance of genggong music in Batuan Village, Sukawati District, Gianyar Regency. This study aimed to determine: (1) the form of genggong music performance in Batuan Village, Sukawati District, Gianyar Regency. (2) The function of Genggong Music Performance in Batuan Village, Sukawati District, Gianyar Regency. (3) The values of Hindu religious education are contained in the genggong music performance in Batuan Village, Sukawati District, Gianyar Regency. The method used to collect data is observation, interviews, documentation, and literature study. The data analysis technique in this study was through three stages, namely descriptive, data reduction, and conclusion drawing. The result shows: (1) there are several stages in playing genggong music, playing techniques, the duties of each instrument and the composition of the musicians in genggong music performances. (2) The functions of genggong music performance in Batuan Village, Sukawati District, Gianyar Regency, namely social functions, aesthetic functions, expressive functions, and cultural preservation. (3) The value of Hindu religious education contained in the genggong music performance in Batuan Village, Sukawati District, Gianyar Regency, namely the value of religious education, the value of ethical education (morals), the value of event education, the value of social education and cultural values. Based on the results of the study, it can be concluded that the genggong music performance is the work of the "pengangon” (shepherd). On the other hand, some say that the term genggong comes from the sound produced by the instrument when it is exhaled. The sound produced from these gusts is “ngeng” and “ngoring” so the instrument is named genggong.
Estrategia pedagógica para promover valores ambientales frente a la deforestación en estudiantes de primaria en la I.E Panamericana de Icononzo Tolima
Authors: Chala Herrera Jenny Rocio , Montealegre Giraldo Jose Fernando 
Published: July 2023

Esta investigación titulada Estrategia pedagógica para promover valores ambientales frente a la deforestación en estudiantes de primaria en la I.E Panamericana de Icononzo Tolima, tiene como propósito general de la investigación, mitigar la deforestación en la vereda de Boquerón Tolima provocada por diferentes prácticas de la comunidad, pero especialmente la generada por el proyecto de la obra del tercer carril Bogotá Girardot en el kilómetro 15 Bogotá Melgar. El enfoque de la investigación es cualitativo, el alcance es descriptivo y el diseño utilizado fue el de participación acción, la muestra cuenta con una población aproximada de 30 estudiantes a nivel primaria de la Institución Educativa Panamericana, ubicada en la vereda Boquerón, situada en el municipio de Icononzo departamento del Tolima. La técnica que se utilizó fue la de la entrevista y el instrumento un guion de entrevista el primero para realizar un diagnóstico con relación a los conocimientos ambientales que tienen los estudiantes, y un guion de entrevista final, para evaluar el impacto de la estrategia pedagógica a ejecutar, una vez implementada se logró mejorar el conocimiento y practicas por parte de los estudiantes objeto de estudio.
Assessing the Accuracy of TESS Asteroseismology with APOGEE
Authors: Theodoridis Artemis Theano , Tayar Jamie 
Published: July 2023

Abstract
The recent NASA TESS mission has the potential to increase the available asteroseismic sample dramatically, but its precision and accuracy have yet to be confirmed. To date, NASA’s Kepler mission has been considered the gold standard for asteroseismic samples, despite data only being available for a small portion of the sky. TESSs observations cover the whole sky, and previous work has identified 158,000 potential red giant oscillators. Using APOGEE, which is calibrated to the asteroseismic scale of the Kepler data, we show that seismology from TESS is calibrated to the Kepler scale to better than 5% for about 90% of red giants, and has only slight trends with mass, metallicity, and surface gravity. We therefore conclude that current TESS seismic results can already be used for galactic archeology, and future results are likely to be highly transformational to our understanding.
La vestizione delle persone significative durante lâ€™accesso alle visite ai pazienti adulti ricoverati in terapia intensiva. Entriamo nel merito (e nel metodo).
Authors: Bambi Stefano , Lucchini Alberto , Trevisan Monica , Piemonte Guya , Manici Matteo , Comisso Irene , Marchese Filippo , Mattiussi Elisa , Elli Stefano , Fusi Cristian , Bulleri Enrico , Negro Alessandra , Rasero Laura , Iozzo Pasquale 
Published: July 2023

Il concetto di terapia intensiva aperta prevede lâ€™abbattimento delle barriere fisiche, comunicative e temporali rispetto al precedente modello di cura in area critica. A questi tre principi si stanno affiancando nuove sfide: la partecipazione dei familiari alle attivitÃ di nursing e al round di visita medica sul paziente. Al momento, perÃ², rimangono aperte alcune importanti questioni, la mancata risposta alle domande che si pongono ancora oggi dietro il falso mito che vede il familiare come attore di interferenze con le cure e lâ€™assistenza al paziente, e come portatore di infezioni alla persona oggetto delle visite. Lâ€™obiettivo del presente articolo Ã¨ rilevare la presenza di evidenze scientifiche alla base delle attuali raccomandazioni sulle pratiche di vestizione dei visitatori in terapia intensiva.
Editorial
Authors: HADDAM BOUABDALLAH Faiza , CHIALI Ramzi 
Published: July 2023

Multilingualism and Intercultural Diversity in Didactics: Challenges and StrategiesPlurilinguisme, diversité culturelle et identité(s) : enjeux et perspectives didactiques
Guest edited byDr Faiza Haddam BouabdallahandDr Ramzi Chiali
ТАЛШЫҚТЫ БРЭГГ ТОРЛАРЫН ҚОЛДАНУ АЯСЫ ЖӘНЕ ОЛАРДЫ ПАЙДАЛАНУ МҮМКІНДІКТЕРІ
Authors: Кадирбаева Гулим , Чежимбаева Катипа , Вуйцик Вальдемар , Хизирова Мухаббат 
Published: July 2023

Қазіргі кезде талшықты оптикалық байланыс желілерінің пайдалану ауқымы артқан сайын, желінің жұмыс жасауын бақылайтын көмекші құралдар мен құрылғылар – талшықтың сыртқы ортаның әсерінен болған қысымына және ортаның температурасына тәуелділігін анықтау маңыздылығы артуда. Мақалада талшықты Брэгг торына (ТБТ) негізделген температуралық және деформациялық сенсорларды үлкен қашықтықта орналасқан және қауіпті әртүрлі жарылғыш, күшті электромагниттік сәуле шығаратын орталарда, мұнай, газ құбырларындағы температура мен қысымды өлшеуге, магистралды талшықты байланыс желісі жүргізілген орталардағы температураны анықтау мақсатында кеңінен қолданатындылығы сипатталады. Сонымен қатар, Брэгг толқын ұзындығының ығысуының деформацияға және де температураға тәуелділігі көрсетілді. Жұмыста жалпы талшықты Брэгг торларының маңыздылығы, сонымен бірге оларлдың байланыс салаларында қолданылуы көрсетілді. Жұмыстың негізгі мақсаты - талшықты Брэгг торларымен таныстыру , жалпы ұғымдар және талшықты брэгг торларын қолдану аясы және оларды пайдалану мүмкіндіктерін көрсету болып табылады.
ҚАЗАҚСТАННЫҢ ТЕМІРЖОЛ ӨТКЕЛДЕРІНДЕГІ АВАРИЯЛЫҚ ЖАҒДАЙЛАРДЫ ТАЛДАУ
Authors: Сансызбай Қанибек , Бахтиярова Елена , Батырханов Муслим , Тасболатова Лаура , Сагмединов Данияр 
Published: July 2023

Мақала пайдаланылған жүйелер мен олардың элементтерінің физикалық және моральдық тозуына, көлік ағынының қарқындылығы мен тығыздығының артуына, апаттық жағдайлардың көбеюіне және т. б. байланысты туындайтын теміржол переездеріндегі проблемалық мәселелерді шешуге бағытталған. Теміржол инфрақұрылымында теміржолдардың автомобиль жолдарымен бір деңгейде қиылысу орындары ең қауіпті және күрделі учаскелер болып табылады, өйткені теміржол және автомобиль көліктерінің тиімділігі олардың қауіпсіз және ақаусыз жұмыс істеуіне байланысты. Қазіргі уақытта қозғалыс жылдамдығының және жылжымалы құрамның массасының артуына, сондай-ақ автомобильдер паркінің ұлғаюына байланысты күзетілетін және күзетілмейтін переездердегі жағдайлардың өзгеруі байқалады. Авариялық жағдайлардың өсуі, істен шығу санының артуы байқалады. Мақалада соңғы 5 жылдағы Қазақстан Республикасындағы теміржол переездеріндегі авариялық жағдайларға талдау жасалады, шет елдердің теміржол переездеріндегі жағдайларға және олардың бар проблемаларды шешу жолдарын іздеудегі тәжірибесіне талдау жасалады. Мақалада жылжымалы автоматиканың дамыған моделі зерттеледі, онда оның бес негізгі торабы ұсынылған, олардың ақаулары қозғалыстың қауіпсіздігіне қауіп төндіруі мүмкін. Сондай-ақ, переездік инфрақұрылымның негізгі объектілерінде қауіпсіздікті бұзу тәуекелдерін айқындау мақсатында переездік құрылғылардың өзара іс-қимыл моделі салынды.
Value Chain Analysis of the Marine Ornamental Reef: A Case Study in Banyuwangi, East Java, Indonesia
Authors: Intyas Candra Adi , Tjahjono Agus , Koestiono Djoko , Riana Fitria Dina , Suhartini Suhartini 
Published: July 2023

Coral is the main component of coral reefs and forms an ecosystem that is home to approximately 93 000 species of marine biota. In their development, corals are traded and become decorations in aquariums because of their beauty. Currently, in Indonesia, the trade in ornamental corals is still on an export scale, including hard coral species, which are strictly monitored because some are included in the Convention on International Trade in Endangered Species of Wild Fauna and Flora Appendix II. This research aimed to analyze the ornamental coral value chain at an ornamental coral company in Banyuwangi related to value-added activities, governance, and profit margins to see economic and environmental sustainability using the Porter value chain. The results showed that the primary activities that still needed to be more optimal were operational activities and outbound logistics, environmental factors (weather conditions), and improper handling causing coral death or damage (wounds). Meanwhile, the secondary activities that could have been more optimal are infrastructure and technology development. The profit margin obtained by the company was 97 523.53 US dollars with a value of 45.16% of revenue, showing that the business is profitable. Therefore, infrastructure improvements and technology development are still needed for optimal results. Further research is recommended to be conducted in relation to business development strategies and improvement of coral quality and packaging processes. Additionally, in order to support better traceability and long-term business sustainability for corals, the dearth of historical data on the ornamental coral trade in Indonesia needs to be tackled.
Pengaruh Edukasi Terapi Non Farmakologi pada Pasien Hipertensi
Authors: Fadillah Raisa Noer , Rindarwati Asti Yunia 
Published: July 2023

Hypertension, also known as high blood pressure, is a condition where a person's blood pressure is ? 140 mmHg (systolic) and/or ? 90 mmHg (WHO, 2019). Hypertension is often referred to as the "silent killer" because it is often without complaints until it becomes severe and causes disease in other organs. Objectives: The purpose of this study was to determine the effect of non-pharmacological therapy education on hypertensive patients for the success of their treatment therapy so that their blood pressure can return to normal. Methods This study was conducted by sampling data collection in June 2022 at Derwati Pharmacy in Bandung, West Java. The data collected was on patients who had hypertension results above normal or the results given were ?140 mmHg (systolic) and / or ? 90 mmHg by direct examination using a tension device. Patients are given education about what is recommended and not recommended so that blood pressure can drop to normal. The results of the study can be that the provision of non-pharmacological therapy education to hypertensive patients at Derwati Pharmacy in June 2022 can help reduce high blood pressure (hypertension).

Hipertensi atau disebut dengan darah tinggi dalah suatu keadaan dimana tekanan darah seseorang ?140 mmHg (sistolik) dan/atau ? 90 mmHg (WHO, 2019). Hipertensi sering disebut sebagai "silent killer" karena sering tanpa keluhan hingga menjadi parah dan menimbulkan penyakit pada organ lainnya. Tujuan penelitian: untuk mengetahui pengaruh dari edukasi terapi non farmakologi pada pasien hipertensi untuk keberhasilan terapi pengobatannya sehingga tekanan darahnya dapat normal kembali. Metode Penelitian: pengumpulan data secara sampling pada bulan Juni 2022 di Apotek Derwati Bandung Jawa Barat. Data yang dikumpulkan adalah pada pasien yang memiliki hasil hipertensi di atas normal atau hasil yang diberikan adalah ?140 mmHg (sistolik) dan/atau ? 90 mmHg dengan pemeriksaan secara langsung menggunakan alat tensi. Pasien diberikan edukasi mengenai hal apa saja yang dianjurkan dan tidak dianjurkan agar tekanan darah bisa turun Hingga normal. Hasil penelitian: pemberian edukasi terapi non farmakologi pada pasien hipertensi di Apotek Derwati pada bulan Juni 2022 dapat membantu menurunkan tekanan darah tinggi (Hipertensi).
PENERAPAN SUPERVISI EDUKATIF KOLABORATIF SECARA PERIODIK UNTUK MENINGKATKAN KINERJA GURU DALAM PEMBELAJARAN DI SDN 1 SUKADANA
Authors: Herlinda  
Published: July 2023

Tujuan penelitian untuk mentetahui kinerja dan wawasan guru dalam pembelajaran di SDN 1 Sukadana. Studi dari kegiatan ini berjudul “Memperbaiki Performa Guru dalam Pembelajaran Kelas Melalui Pengawasan Pendidikan Kolaboratif Secara Periodik di SDN 1 Sukadana”. Rumusan masalah penelitian adalah: (1) Apakah dengan supervisi edukatif kolaboratif secara periodik dapat meningkatkan kinerja guru dalam menyusun rencana pembelajaran? (2) Apakah dengan supervisi edukatif kolaboratif secara periodik dapat meningkatkan kinerja guru dalam melaksanakan pembelajaran? (3) Apakah dengan supervisi edukatif kolaboratif secara periodik dapat meningkatkan guru dalam menilai prestasi belajar siswa? (4) Apakah dengan supervisi edukatif kolaboratif secara periodik dapat meningkatkan guru dalam melaksanakan tindak lanjut hasil penilaian prestasi belajar siswa?.
Subjek penelitian adalah supervisor, guru, dan siswa. Jenis penelitian ini adalah penelitian tindakan kelas. Hasil diskusi diperoleh langkah-langkah pemecahan, yakni: (1) mengadakan workshop singkat tentang pembuatan persiapan pembelajaran, pelaksanaan, dan penilaian pembelajaran di sekolah, (2) melaksanakan supervisi edukatif kolaboratif secara periodik dengan menekankan pada pemberian bantuan untuk perbaikan pembelajaran.
Hasil penelitian menyimpulkan bahwa: (1) terdapat peningkatan kinerja guru dalam menyusun rencana pembelajaran, (2) Peningkatan kinerja guru dalam melaksanakan pembelajaran, (3) Peningkatan kinerja guru dalam menilai prestasi belajar, dan (4) Peningkatan kinerja guru dalam melaksanakan tindak lanjut hasil penilaian prestasi belajar siswa.