bluuebunny/crossref_metadata_2025_split huggingface dataset:
Household animal ownership is associated with infant animal source food consumption in Bangladesh
Authors: Pasqualino Monica M. , Shaikh Saijuddin , Islam Md Tanvir , Parvin Shahnaj , Ali Hasmot , McGready John , Labrique Alain B. , Hossain Md Iqbal , Palmer Amanda C. 
Published: April 2023

AbstractContext‐specific research is needed on the relationship between household animal production and nutrition outcomes to inform programmes intervening in small‐scale animal production. We examined associations between household animal/fishpond ownership and animal source food (ASF) consumption among 6‐ to 12‐month‐old infants enroled in the control arm of a cluster‐randomised controlled trial in rural Bangladesh. We measured ASF consumption using a 7‐day food frequency questionnaire at 6, 9 and 12 months and assessed household animal/fishpond ownership at 12 months. We developed negative binomial regression models with random intercepts for infant and cluster, controlling for infant age and sex, maternal age, socioeconomic status and season. Models were stratified by a dichotomised maternal decision‐making score. Compared with infants in households without each animal type, those with 4–10 and ≥11 poultry consumed eggs 1.3 (95% confidence interval [CI]: 1.1, 1.6) and 1.6 (95% CI: 1.3, 2.0) times more, respectively; 2–3 and ≥4 dairy‐producing animals consumed dairy 1.9 (95% CI: 1.3, 2.7) and 2.0 (95% CI: 1.3, 3.1) times more, respectively; and ≥12 meat‐producing animals consumed meat 1.4 (95% CI: 1.0, 1.8) times more. It was unclear whether there was an association between fishpond ownership and fish consumption. Our results did not suggest that maternal decision‐making power was a modifier in the relationship between animal/fishpond ownership and ASF consumption. In this South Asian context, strategies intervening in household animal production may increase infant consumption of eggs, dairy and meat, but not necessarily fish. Research is needed on the role of market access and other dimensions of women's empowerment.
Existence and the existential quantifier
Authors: Rabin Gabriel Oak 
Published: April 2023

AbstractThis paper draws a distinction between the existential quantifier and the symbol ‘∃’ used to express it, on the one hand, and existence and ‘exists’, on the other. It argues that some popular arguments in metaphysics, including arguments against vague existence and arguments against deflationary metaontology (which views ontological disputes as lacking substance), are guilty of fudging this distinction. The paper draws some lessons for metaphysical debate about existence and highlights some heretofore ignored and attractive positions in logical space.
Effect of manipulating the vergence/accommodation and image size mismatches of the ±2D flipper test on the frequency and precision of accommodative facility
Authors: Vera Jesús , Redondo Beatriz , Martínez‐Tovar José Miguel , Molina Rubén , Koulieris George A. , Allen Peter M. , Jiménez Raimundo 
Published: April 2023

AbstractPurposeThe ±2.00 D accommodative facility test presents several limitations, including the lack of objective information and inherent characteristics such as vergence/accommodative conflict, change in apparent size of the image, subjective criteria for judging blur and motor reaction time. By using free‐space viewing conditions and an open‐field autorefractor to monitor the refractive state, we examined the impact of manipulating these factors on the qualitative and quantitative assessment of accommodative facility.MethodsTwenty‐five healthy young adults (24.5 ± 4.5 years) took part in this study. Participants performed three accommodative facility tests (adapted flipper, 4D free‐space viewing and 2.5D free‐space viewing) under both monocular and binocular conditions in random order. A binocular open‐field autorefractor was used to assess the accommodative response continuously, and these data were used to characterise accommodative facility quantitatively and qualitatively.ResultsThere were statistically significant differences between the three testing methods both quantitatively (p < 0.001) and qualitatively (p = 0.02). For the same accommodative demand, a lower number of cycles was obtained for the adapted flipper condition in comparison with the 4D free‐space viewing test (corrected p‐value < 0.001, Cohen's d = 0.78). However, this comparison did not reach statistical significance for qualitative measures of accommodative facility (corrected p‐value = 0.82, Cohen's d 0.05).ConclusionsThese data provide evidence that the qualitative assessment of accommodative facility is not influenced by the inherent limitations of the ±2.00 D flipper test. The use of qualitative outcomes by incorporating an open‐field autorefractor allows examiners to increase the validity of the accommodative facility test in both clinical and research settings.
Regulation of lipid metabolism by gut microbiota in aquatic animals
Authors: Wu Shangong , Pan Meijing , Zan Ziye , Jakovlić Ivan , Zhao Weishan , Zou Hong , Ringø Einar , Wang Guitang 
Published: April 2023

AbstractLipids are an essential component of living beings and an important group of nutrients. As the gut microbiota plays important roles in the intestinal absorption and extraintestinal metabolism of dietary lipids, the current review addresses the recent progress regarding the interactions between the gut microbiota and lipid metabolism in aquatic animals, with a focus on fish. We discuss in detail how dietary lipid sources and content affect the composition of the gut microbiome and the mechanism by which the gut microbiota affects the lipid metabolism of the host. This interaction is largely mediated via microbial lipases, short‐chain fatty acids and the gut‐liver axis. The latter refers to the metabolism of biliary salts and acids, the regulation of their synthesis by gut microbes and their impact on the lipid metabolism. Finally, we briefly discuss how probiotic supplementation modulates the host's microbiome, and how probiotics have a beneficial effect on health and welfare of farmed aquatic animals. Although the influence of intestinal microbiota on lipid metabolism has been explored before, further research is needed to profoundly investigate the molecular mechanisms by which microbial metabolites (SCFAs and bile acids) induce lipid metabolism.
How to convert whole‐blood donors to plasma donors: An investigation of the mechanisms of awareness of need for plasma and donors' perception of response efficacy
Authors: Saltzmann Carolin 
Published: April 2023

AbstractBackgroundBlood donation services need to increase plasma donations to match the rising demand. However, evidence on how to best recruit donors among whole‐blood donors is limited. Therefore, this study evaluated the effectiveness of a conversion strategy based on two different mechanisms that drive donor behavior: (a) awareness of the need for plasma donation and (b) perception of response efficacy regarding plasma donation.Study Design and MethodsAn online experiment with 246 German Red Cross whole‐blood donors (possibility of plasma donation, blood group AB) was conducted using a 2 × 2 factorial, between‐subject setup, and a pre–post treatment measurement. The mechanisms varied and were addressed with experimental treatments and measured. Analyses of variance and hierarchical regression models were used to analyze the effects on intention and behavior.ResultsThe intention to donate plasma was low, but increased with treatment (mean valueoverall of intentionbeforeTreatment = 2.63, SD = 1.73 vs. intentionafterTreatment = 3.28, SD = 1.92). Furthermore, 31% of participants expressed willingness to be forwarded to the appointment‐scheduling system of the blood donation service for further information. Only the mechanism of response efficacy was significantly associated with the intention to donate plasma (βEfficacy = .254, p = .001; βAwareness of Need = .126, p = .070).DiscussionA conversion strategy based on making donors aware of their response efficacy is a promising way to optimize donor panels by shifting them to where they have the greatest impact. However, this study also substantiates the difficulty of such an effort. Blood donation services should invest in persuasion efforts and build personalized integrated marketing communications.
Novel Echocardiographic Metrics Predict Tricuspid Insufficiency in Pediatric Ebstein Anomaly
Authors: Liu Wei , Wen Chen , Shentu Jin , Zhang Yuqi , Zhu Zhongqun , Chen Lijun , Chen Huiwen 
Published: April 2023

Objectives. The tricuspid anterior leaflet is considered important in most repair techniques for Ebstein anomaly (EA). We aim to assess the anterior leaflet morphology using novel metrics and investigate the association of the morphology with recurrent moderately severe or greater tricuspid regurgitation (TR). Methods. Seventy-four paediatric patients with EA undergoing cone reconstruction (CR) between 2010 and 2021 were included. Anterior leaflet mobility (ALM) and anterior leaflet length (ALL) were remeasured on preoperative 2D echocardiography. The prediction accuracies of ALM and ALL-I (ALL indexed to body surface area) for recurrent TR were evaluated using receiver operating characteristic (ROC) curve analyses. Results. The median age of patients was 3.3 years (interquartile range, 1.9–7.1 years). Both ALM and ALL-I correlated with the Carpentier type and GOSH score. Nine patients (12.2%) developed recurrent TR during the one-year follow-up. By univariable logistic regression analyses, ALM (odds ratio [OR], 0.89; 95% CI [confidence interval], 0.82–0.96;

p

= 0.003) and ALL-I (OR, 1.39; 95% CI, 1.08–1.78;

p

= 0.011) were risk factors for recurrent TR. ROC curve analyses showed that ALM (AUC = 0.81) and ALL-I (AUC = 0.77) had better predictive performance for recurrent TR compared with the GOSH score (AUC = 0.68), the Carpentier type (AUC = 0.67), and preoperative TR severity (AUC = 0.58), and the combinations of ALM and ALL-I (AUC = 0.87) improved the predictive performance compared with ALM or ALL-I alone. Conclusions. ALM and ALL-I can help optimize evaluation in the anterior leaflet morphology and predict recurrent TR after CR in pediatric EA.
Characteristics of Biofoam Cups Made from Sugarcane Bagasse with Rhizopus oligosporus as Binding Agent
Authors: Indarti Eti , Muliani Sri , Yunita Dewi 
Published: April 2023

This study is aimed at producing a biofoam cup made from sugarcane bagasse with tempeh mold (Rhizopus oligosporus). Soybean flour (SF) was added to promote the growth of mycelia, which could bind the bagasse fiber matrix. The main materials were whole bagasse (B) and depithed bagasse (DB). The SF weight ratios to bagasse were 1 : 1 (SF1) and 1.5 : 1 (SF1.5). Therefore, the studied specimens were labeled B-SF1, DB-SF1, B-SF1.5, and DB-SF1.5. All biofoam cups were analyzed for their physical properties (water absorption and porosity), mechanical properties (puncture and compressive strengths), biodegradability, and thermal properties (thermogravimetric analysis). The lowest water absorption rates were obtained from the B biofoam cups (

23
%
±
2.45
%

) and the SF1.5 biofoam cups (

25.83
%
±
5.19
%

). Both B-SF1 and B-SF1.5 had lower porosity (

8.72
%
±
0.88
%

and

10.77
%
±
1.54
%

, respectively) than the DB biofoam cups. Moreover, the B biofoam cups had smoother biofoam surfaces, smaller voids, and lower porosity compared with the DB samples. However, the DB biofoam cups showed the highest puncture strength (

2.95
±
0.37

kg cm−2) among all samples. Nevertheless, the B-SF1.5 biofoam cup had the highest compressive strength (

3.98
±
0.39

MPa) and the DB-SF1.5 exhibited the slowest degradation rate (

27
%
±
0.7
%

) after 14 days of soil burial. The highest thermal stability was obtained from B-SF1.5, which had a thermal degradation temperature of 264°C. Overall, B-SF1.5 had the smoothest surface, good thermal stability, and high compressive strength.
Supplementary Figure 5 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Authors: Fultang Livingstone , Gamble Laura D. , Gneo Luciana , Berry Andrea M. , Egan Sharon A. , De Bie Fenna , Yogev Orli , Eden Georgina L. , Booth Sarah , Brownhill Samantha , Vardon Ashley , McConville Carmel M. , Cheng Paul N. , Norris Murray D. , Etchevers Heather C. , Murray Jayne , Ziegler David S. , Chesler Louis , Schmidt Ronny , Burchill Susan A. , Haber Michelle , De Santo Carmela , Mussai Francis 
Published: April 2023

<p>Supplementary Figure 5 : IL-1ï�¢ï€ and TNF-ï�¡ï€ drive neuroblastoma cell proliferation</p>
Supplementary Appendix from Extended Treatment with Single-Agent Ibrutinib at the 420 mg Dose Leads to Durable Responses in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Authors: Coutré Steven E. , Furman Richard R. , Flinn Ian W. , Burger Jan A. , Blum Kristie , Sharman Jeff , Jones Jeffrey , Wierda William , Zhao Weiqiang , Heerema Nyla A. , Johnson Amy J. , Tran Anh , Zhou Cathy , Bilotti Elizabeth , James Danelle F. , Byrd John C. , O'Brien Susan 
Published: April 2023

<p>Supplementary Table S1: Patient disposition; Supplementary Table S2: Summary of adverse events; Supplementary Table S3: Response improvement and durability; Supplementary Table S4: Best response in patients who achieved PR with lymphocytosis; Supplementary Table S5: Outcomes by cytogenetics (FISH) in the relapsed/refractory population; Supplementary Figure 1: Outcomes by cytogenetics (FISH) in the relapsed refractory population. (A) Progression-free survival and (B) overall survival in cytogenetic subgroups in patients with R/R CLL/SLL.</p>
Data from Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy
Authors: Chandramohan Vidyalakshmi , Bao Xuhui , Keir Stephen T. , Pegram Charles N. , Szafranski Scott E. , Piao Hailan , Wikstrand Carol J. , McLendon Roger E. , Kuan Chien-Tsun , Pastan Ira H. , Bigner Darell D. 
Published: April 2023

<div>Abstract<p><b>Purpose:</b> The EGF receptor gene (<i>EGFR</i>) is most frequently amplified and overexpressed, along with its deletion mutant, <i>EGFRvIII</i>, in glioblastoma. We tested the preclinical efficacy of the recombinant immunotoxin, D2C7-(scdsFv)-PE38KDEL, which is reactive with a 55-amino acid (AA) region present in the extracellular domain of both EGFRwt (583-637 AAs) and EGFRvIII (292-346 AAs) proteins.</p><p><b>Experimental Design:</b> The binding affinity and specificity of D2C7-(scdsFv)-PE38KDEL for EGFRwt and EGFRvIII were measured by surface-plasmon resonance and flow cytometry. <i>In vitro</i> cytotoxicity of D2C7-(scdsFv)-PE38KDEL was measured by inhibition of protein synthesis in human EGFRwt-transfected NR6 (NR6W), human EGFRvIII-transfected NR6 (NR6M), EGFRwt-overexpressing A431-epidermoid-carcinoma, and glioblastoma xenograft cells (43, D08-0493MG, D2159MG, and D270MG). <i>In vivo</i> antitumor efficacy of D2C7-(scdsFv)-PE38KDEL was evaluated using 43, NR6M, and D270MG orthotopic tumor models.</p><p><b>Results:</b> The <i>K</i><sub>D</sub> of D2C7-(scdsFv)-PE38KDEL for EGFRwt and EGFRvIII was 1.6 × 10<sup>−9</sup> mol/L and 1.3 × 10<sup>−9</sup> mol/L, respectively. Flow cytometry with NR6W and NR6M cells confirmed the specificity of D2C7-(scdsFv)-PE38KDEL for EGFRwt and EGFRvIII. The D2C7-(scdsFv)-PE38KDEL IC<sub>50</sub> was 0.18 to 2.5 ng/mL on cells expressing EGFRwt (NR6W, A431, 43, and D08-0493MG). The D2C7-(scdsFv)-PE38KDEL IC<sub>50</sub> was approximately 0.25 ng/mL on EGFRvIII-expressing cells (NR6M) and on EGFRwt- and EGFRvIII-expressing glioblastoma xenograft cells (D2159MG and D270MG). Significantly, in intracranial tumor models of 43, NR6M, and D270MG, treatment with D2C7-(scdsFv)-PE38KDEL by convection-enhanced delivery prolonged survival by 310% (<i>P</i> = 0.006), 28% (<i>P</i> = 0.002), and 166% (<i>P</i> = 0.001), respectively.</p><p><b>Conclusions:</b> In preclinical studies, the D2C7-(scdsFv)-PE38KDEL immunotoxin exhibited significant potential for treating brain tumors expressing EGFRwt, EGFRvIII, or both. <i>Clin Cancer Res; 19(17); 4717–27. ©2013 AACR</i>.</p></div>
Data from Evaluation of Sensitivity to Endocrine Therapy Index (SET2,3) for Response to Neoadjuvant Endocrine Therapy and Longer-Term Breast Cancer Patient Outcomes (Alliance Z1031)
Authors: Suman Vera J. , Du Lili , Hoskin Tanya , Anurag Meenakshi , Ma Cynthia , Bedrosian Isabelle , Hunt Kelly K. , Ellis Matthew J. , Symmans W. Fraser 
Published: April 2023

<div>AbstractPurpose:<p>To evaluate prediction of response and event-free survival (EFS) following neoadjuvant endocrine therapy by SET2,3 index of nonproliferation gene expression related to estrogen and progesterone receptors adjusted for baseline prognosis.</p> Experimental Design:<p>A correlative study was conducted of SET2,3 measured from gene expression profiles of diagnostic tumor (Agilent microarrays) in 379 women with cStage II–III breast cancer from the American College of Surgeons Oncology Group Z1031 neoadjuvant aromatase inhibitor trial SET2,3 was dichotomized using the previously published cutoff. Fisher exact test was used to assess the association between SET2,3 and low proliferation at week 2–4 [Ki67 ≤ 10% or complete cell-cycle arrest (CCCA; Ki67 ≤ 2.7%)] and PEPI-0 rate in cohort B, and the association between SET2,3 and ypStage 0/I in all patients. Cox models were used to assess EFS with respect to SET2,3 excluding cohort B patients who switched to chemotherapy.</p>Results:<p>Patients with high SET2,3 had higher rate of pharmacodynamic response than patients with low SET2,3 (Ki67 ≤ 10% in 88.2% vs. 56.9%, <i>P</i> < 0.0001; CCCA in 50.0% vs. 26.2%, <i>P</i> = 0.0054), but rate of ypStage 0/I (24.0% vs. 20.4%, <i>P</i> = 0.4580) or PEPI = 0 (28.4% vs. 20.6%, <i>P</i> = 0.3419) was not different. Patients with high SET2,3 had longer EFS than patients with low SET2,3 (HR, 0.52, 95% confidence interval: 0.34–0.80; <i>P</i> = 0.0026).</p>Conclusions:<p>This exploratory analysis of Z1031 data demonstrated a higher rate of pharmacodynamic suppression of proliferation and longer EFS in high SET2,3 disease relative to low SET2,3 disease. The ypStage 0/I rate and PEPI = 0 rate were similar with respect to SET2,3.</p></div>
On the phylogenetic status of Contortylenchus genitalicola Kosaka & Ogura, 1993
Authors: Kanzaki Natsumi , Kosaka Hajime , Fujimori Yuta , Akiba Mitsuteru 
Published: April 2023

Summary
Contortylenchus genitalicola is a unique species within the genus. It parasitises the ovary or testis of the longhorn beetle, Monochamus alternatus, and has a neotylenchid-like culturable mycetophagous phase within its life cycle, while the other species in the genus parasitise bark beetles and have a typical unculturable allantonematid life cycle. Because the species was described based solely on morphology, it was necessary to confirm the phylogenetic and taxonomic status of C. genitalicola. A molecular phylogenetic analysis of the species based on ribosomal RNA sequences revealed that C. genitalicola forms a well-supported clade with Contortylenchus spp. isolated from bark beetles, an unidentified allantonematid from Iran, and ‘Deladenus cf. laricis’ isolated from the metallic wood-boring beetle, Agrilus macer LeConte (Coleoptera: Buprestidae), in the USA. The generic status of C. genitalicola was supported by phylogenetic analysis, and the analysis also suggests that the diversity of the genus could be higher than currently expected.
How can legal interpretation change the legal order into legal disorder? (Lessons from the Czech Republic)
Authors: Beran Karel 
Published: April 2023

Abstract
An opinion long prevailed in the Czech Republic that a judge is bound, in his decision-making, only by statutory law and by international treaties which, according to the Constitution of the Czech Republic, have priority over statutory law. The fact that a judge is bound by statutory law was mostly understood in that the judge is bound by the “word of the statutes”. A judge thus could not be formally bound by someone else’s interpretation of the statutes, i.e. by case law. However, both these basic assumptions began to change radically in the Czech Republic, especially following the adoption of the new Civil Code in 2012. This article therefore aims to present the transformations in the binding effect of case law in the Czech Republic at the beginning of the 21st century and, in doing so, it will concentrate on the yet insufficiently examined question of limits to judicial law-making in the sense of constructive interpretation of statutory law by courts.
When a judge applies the law, and thus necessarily also interprets it, he must ask two fundamental questions: (i) Whether he/she is bound by interpretation of the statutory law which has already been provided by someone else, and the judge is thus obliged to adhere to this line of interpretation. (ii) How should he/she proceed in the interpretation, which comprises the question of what methods of interpretation he/she should use, in what order and what significance should be attached to these methods?
The ambition of this article is to show why a “discursive” or “conditional binding effect of case law”, on the one hand, and a judge’s competence to interpret the law, on the other hand, can lead to fragmentation of the Czech legal order and contribute to transformation of the law from an order to a disorder, and how these unfavourable tendencies can be eliminated, or at least mitigated.
COVID-19 Crisis and the Association Between Inequality and Economic Growth
Authors: Chahine Salim , Chahine Adam 
Published: April 2023

In this paper, we investigate the macroeconomic response to exogenous shocks, namely the COVID-19. We conjecture that the sensitivity of an economic system to an exogenous shock is endogenous on its characteristics and ability to counter a shock. We use the COVID-19 crisis as an exogenous shock, and we argue that a higher income inequality is likely to lead to a greater negative impact of an exogenous shock on economic growth. We validate our expectations using different inequality indexes. In further robustness tests, we confirm our conclusions using different proxies for economic conditions. JEL Codes: A10, I14, I15
Obesity and Food Access: Do Consumer Preferences Matter
Authors: Coyle Sara , Keehan Sean , Schwartz Jeremy 
Published: April 2023

The existing literature is mixed on the degree and type of food access that matters for obesity. This may be because studies do not consider the degree that consumers are satisfied with the local food establishments. For instance, a supermarket may have little impact on obesity if consumers prefer to go elsewhere. This paper contributes to the literature by disaggregating different aspects of the food environment, exploring smaller geographic areas than many other studies, and examining whether consumer preferences for different food establishments matter. We find evidence that the benefits of supermarkets in reducing obesity are concentrated in those preferred by consumers. In addition, while less robust, we find the negative effects of convenience stores, and takeout restaurants are mostly attributable to poorly rated establishments. Policy should focus on not only addressing food deserts but also areas that have supermarkets that consumers feel are poor options. JEL Codes: I12, D12, Q18, R3