bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cross-sectional study on the prediction model of fear of cancer recurrence in individuals with non-small cell lung cancer
Authors: Liu Man , Liu Lu , Wang Hongjing , Song Peng , Li Jinghan , Guo Wei , Liu Yan 
Published: March 2023

Abstract
Objective
To study the fear of cancer recurrence (FCR) of individuals with non-small cell lung cancer (NSCLC); this research focused on developing and validating a prediction model to identify which individuals with NSCLC were at high risk of relapse fear.
Methods
The sociodemographic and clinical variable data of 347 NSCLC patients from the Department of Thoracic Surgery, Cancer Hospital of Chinese Academy of Medical Sciences from December 2020 to September 2022 were collected by convenience sampling. The t-test, ANOVA, and nonparametric test were used to test the difference of a single factor in the disease fear scores of patients with NSCLC with different demographic characteristics and disease-related conditions. After the disease fear scores were converted into binary data (fear and no fear), the univariate logistic regression analysis was conducted according to the univariate analysis. Multivariate logistic regression analysis was conducted by adjusting the relevant covariates to establish a risk prediction model for NSCLC patients to fear disease progression.
Results
Gender, ethnicity, family per capita monthly income, and hope level were independent predictors of cancer recurrence fear in patients with non-small cell lung cancer. The model established by these predictors showed that the area under the curve was 0.891,95% confidence interval:0.858–0.924.
Conclusion
This study developed a validated and easy-to-use prediction algorithm that can be used to identify patients at high risk of recurrence fear with moderate accuracy.
Sustainable Solvent Recycling Strategy Toward Environmentally Viable Perovskite Solar Cells
Authors: Kim Hee Jung , Gong Oh Yeong , Kim Young Ju , Yoon Geon Woo , Han Gill Sang , Shin Hyunjung , Jung Hyun Suk 
Published: March 2023

Abstract
In the pursuit of eco-friendly and cost-effective commercialization of perovskite solar cells (PSCs), efforts have been made to develop recycling technologies. However, most current methods use toxic solvents that can potentially harm human health and the environment. Here, we introduce a novel approach that recovers and reuses toxic solvents used in the recycling process. Detailed evaluations were conducted to assess the effects of residual substances in PSC-dissolved solvents, and a two-step selective dissolution process was utilized for effective solvent recycling. PSCs were immersed in chlorobenzene and N,N′-dimethylformamide solvents in sequence, and each solvent was recovered for reuse in the re-fabrication of PSCs. Our results demonstrate the feasibility of a toxic solvent recycling process for PSC re-fabrication, which achieved a power conversion efficiency of 25.02%, comparable to that of the original PSCs (25.12%), as well as recycling of the dissolved hole conducting materials.
Indigenous knowledge and perception toward mental illnesses within Goma city in Democratic Republic of Congo
Authors: Kyolo Samuel Kule , Bbosa Godfrey S. , Odda John , Mwebaza Norah , Kibendelwa Zacharie Tsongo , Nakasujja Noeline , Katuura Esther 
Published: March 2023

Abstract

Background: Prevailing wars for more than two decades have been associated with the increased burden of mental illnesses (MIs) in North-Kivu province (NKP), in Democratic Republic of Congo (DRC). The community perception of this claim has, however, not been fully documented.
Aims:To assess the knowledge and perception of Goma city residents on MI and their associated factors.
Methods: Cross sectional study, was conducted among 610 selected community residents including key informants of Goma city from April to July 2021. Quantitative data from semi-structured interviews was analyzed using descriptive statistics and binary logistic regression, while data from FGDs were analyzed using qualitative thematic analysis.
Results: Among residents of Goma city, rates of correct recognition of MIs namely schizophrenia, anxiety, depression and neurodevelopment disorders varied: 96.6%, 29.7%, 39.5% and 14.3%, respectively. The major causes of MIs perceived by respondents were spiritual (67.5%) and substance abuse (56.7%). Qualitative data from FGD’s revealed three major themes for poor perception of MI among residents as indigenous names of various MIs, reason of preferring traditional medicine versus conventional medicine (CM) and challenges faced in management of MIs using CM. Furthermore, demographic factors such as education, religion, occupation and age were not statistically significant (p˃0.05) in predicting one’s odds of MI perception among Goma city residents.
Conclusion:The findings revealed that residents of Goma city have poor knowledge and perception about MIs regardless of education, religion, occupation and age.
A phase II study of High-Flow Nasal Cannula for relieving dyspnea in advanced cancer patients.
Authors: Takase Eri , Akamatsu Hiroaki , Teraoka Shunsuke , Nakaguchi Keita , Tanaka Masanori , Kaki Takahiro , Furuta Katsuyuki , Sato Koichi , Murakami Eriko , Sugimoto Takeya , Shibaki Ryota , Fujimoto Daichi , Hayata Atsushi , Tokudome Nahomi , Ozawa Yuichi , Koh Yasuhiro , Nakanishi Masanori , Kanai Kuninobu , Shimokawa Toshio , Yamamoto Nobuyuki 
Published: March 2023

Abstract
Background: The efficacy and tolerability of high-flow nasal cannula (HFNC) for relieving dyspnea in advanced cancer patients with limited prognosis requires elucidation.
Methods: Patients with advanced cancer who had dyspnea at rest (numeric rating scale, NRS≥3) and respiratory failure were enrolled. They were treated with HFNC for five days. Primary endpoint was change of mean modified Borg scale at 24 hours. Key secondary endpoints consisted of change in modified Borg scale during the study period and feasibility (Trial Identifier, UMIN000035738).
Results: Between February 2019 and February 2022, 25 patients were enrolled and 21 were analyzed. Twenty patients used inspired oxygen and the mean fraction of inspired oxygen (FiO2) was 0.34 (range, 0.21–1.0). At baseline, mean NRS (dyspnea) was 5.9 (range, 3–10). Median survival time was 19 days (range, 3–657).
The change of mean modified Borg scale was 1.4 (80% confidence interval [CI]: 0.8–1.9) at 24 hours, 11 patients showed 1.5 points improvement of modified Borg scale. Within 1 hour, nine patients showed 1.5 points improvement of modified Borg scale and such early responders were likely to maintain dyspnea improvement for 24 hours.­ Nineteen patients could continue HFNC for 24 hours and 11 patients completed five days of HFNC.
Conclusion: To our knowledge, this trial is the first prospective study to show the efficacy and tolerability of HFNC regarding dyspnea for five days in patients under palliative care. HFNC can be a palliative treatment option in advanced cancer patients with dyspnea.
Pharmacist-led medication reviews: A scoping review of systematic reviews
Authors: Craske Miriam E. , Hardeman Wendy , Steel Nicholas , Twigg Michael J. 
Published: March 2023

Abstract

Background

Medication reviews aim to support patients who take medicines, and they are often led by pharmacists. Previous research undertaken in 2015 found mixed evidence that medication reviews in community settings improve clinical outcomes, but further work needs to be undertaken to establish their impact on patient-orientated and economic outcomes.

Aim

To explore the extent and range of systematic reviews of medication reviews conducted by pharmacists, the nature of the intervention, the evidence for effectiveness, and reported research gaps.

Method

Data extracted included the design of included studies, population, setting, main results, description of interventions, and future research recommendations.

Results

We identified twenty-four systematic reviews which reported that medication review interventions were diverse, and their nature was often poorly described. Two high quality reviews reported that there was evidence of no effect on mortality; of these one reported an improvement in medicines-related problems (all studies reported an increase of identified problems), and another a reduction in hospital readmissions (Risk ratio 0.93). Other lower quality reviews reported evidence supporting intervention effectiveness for some clinical outcomes (odds ratio: achieving diabetes control = 3.11, achieving blood pressure target = 2.73, 3.50).

Conclusion

There is mixed evidence of effectiveness for medication reviews across settings and patient populations. The nature of the intervention is poorly reported therefore it is difficult to determine the components medication review. As medication reviews are widely implemented in practice, further research should explore the nature of the interventions and linking the components of these to outcomes.
WITHDRAWN: Exploring trend and forecasting of temperature and rainfall in Shimla district of Himachal Pradesh, India using non-parametric and bagging REPTree model
Authors: Sharma Aastha , Sajjad Haroon , Saha Tamal Kanti , Masroor Md , Sharma Yatendra , Kumari Geeta 
Published: March 2023

Abstract

The changing pattern of climate variables has caused extreme weather events and severe disasters especially in mountainous regions. Such events have a detrimental impact on resources, environment and society. Thus, it has become imperative to examine trends and forecast of meteorological variables using scientific modeling approach at micro level. This study makes an attempt to examine trend in temperature and rainfall using Modified Mann–Kendall test and Sen’s slope estimator during 1980–2021. A Bagging-REPTree machine learning model was utilized for forecasting temperature and rainfall trend for the next 20 years (2022–2041) to understand the temporal dynamics in Shimla district of Indian Himalayan state. Correlation coefficient (R), mean squared error (MSE), mean absolute error (MAE), and root mean squared error mean (RMSE) performance were determined to assess effectiveness and precision of the model. The findings revealed that the frequency of intense rainfall in the district has increased, especially during the monsoon season (June–September) during 1980–2021. Annual maximum, minimum, and mean temperatures have exhibited significant variability while annual rainfall has shown a decreasing trend. The forecast analysis revealed significant trend for rainfall during monsoon season and increasing trend in the maximum temperature has been observed during summer and winter seasons. The analysis has provided sufficient evidence of variability and uncertainty in the behavior of meteorological variables. The outcome of the study may help in devising suitable adaptation and mitigation strategies to combat the effect of climate change in the hilly regions. The methodology adopted in the study may help in future progression of the research in different geographical regions of Western Himalayas.
Study on the optimization of temperature uniformity in the oven under the forced convection mode
Authors: Yang Zongliang , Cheng Dongxu , Su Bin , Ji Chuang , Huang Jiayu , Li Haiyun , Zhang Kai 
Published: March 2023

Abstract
In order to study the temperature distribution in a multi-functional oven and optimize the structural parameters of the oven, the internal temperature uniformity was improved. The test was conducted and the numerical simulation was conducted in two ways. The distribution of temperature field in each layer of ovens was measured in real time using a 9-point distributed thermocouple, and the oven temperature uniformity index was measured and analyzed. The temperature field inside the oven was numerically simulated using computational fluid dynamics. Investigated the heat conduction, convection and radiation effects respectively, and found out the main heat transfer mode of the oven. Further through the test of temperature measurement, verify the accuracy of the numerical simulation method. According to the results of the experiment and simulation, the reason of the uneven temperature field in the original structure of the oven was revealed and analyzed. By changing the structure of the oven tailgate, adjusting the air volume distribution, changing the distribution of the air outlet and other measures, greatly improving the uniformity of the temperature field inside the oven.
Citrus sinensis agro-waste peels mediated CQDs-Ag nanocomposite potentiates numerous applications
Authors: Chugh Riya , Kaur Gurmeet 
Published: March 2023

Abstract

In chasing green nanoscale research, the reductive efficacy of a typical agro-waste product of the food industry, namely, orange peels, has been investigated to synthesize carbon quantum dots silver nanocomposites [CQDs-Ag NCs] via a greener route. CQDs-Ag NCs are having great importance for their diverse applications in the chemical, medical, biological and agricultural sector including their role in chemical reactions, sensing, catalysis, as nanopesticides or nanofertilizers, antifungal, antimicrobial, anti-bacterial, and antioxidant activity. The synthesis of CQDs-Ag NCs was conducted mainly in 4 steps, namely, composition of orange peels fine powder, phytochemical screening of precursor orange peel extract, orange peel derived fluorescent CQDs by green and facile microwave-assisted method and further biosynthesis of CQDs-Ag NCs. Structural characterization revealed that CQDs-Ag NCs exhibit cubic crystallinity belonging to Ag nanoparticles with few humps belonging to CQDs. The average sizes of orange peels mediated carbon quantum dots were around 5–8 nm. Microstructural analysis of CQDs-Ag NCs showed polydispersed grains with an average size of 15–20 nm. The agar well-diffusion test demonstrated that these nanocomposites are a promising material for antibacterial agents. This assertion was supported by the evidence showing that the diameter of the created clear zone ranges from 12–14 mm. Thus, nanotechnology (CQDs-Ag NCs) can be considered to have great potential in precision agriculture and bactericidal applications.
Epilepsy and Giardia intestinalis infection impact the gut microbiome of canine species.
Authors: Park Chan-Yeong , Lee Sung-Seok , Seo Hyun-Hee , Ha Dong-Uk , Jang Ha-Da , Yu Hyun-Ah , Kim San 
Published: March 2023

Abstract
The role of gut microbiome in the host health is a growing interest and they play various roles for the maintenance of homeostasis. It has been shown that the composition of the microbiome is associated with many factors such as age, race, gender, geographical distribution, and genetic features. Yet, the gut microbiome-host interaction fully remains unknown. Compared to the human, there were limited studies were carried out on the gut microbiome studies on the companion animals. In this study, we analyzed canine gut microbiome with National Center for Biotechnology Information (NCBI) with SRA database. From the SRA database, total 982 SRA data with 1.22 TB from 8 countries were included. According to distance-based redundancy analysis (dbRDA), the Peptoclostridium and Fusobacterium were mostly correlated with disease of Epileptic and Giardia intestinalis, respectively. From the network analysis with spearman rank-based correlation coefficient (ρ), we identified interactions within genera lists as candidate biomarkers. The results showed that the composition of the canine gut microbiome differed with disease specific microbes, suggesting that these species lists are considered as biomarker candidate for epileptic and giardia intestinalis.
Research on Injection Molding Simulation and Process Parameter Optimization of Automobile Front Door Sill Press Plate
Authors: Wang Lu , Tang Lingfeng 
Published: March 2023

Abstract
With the continuous development of plastic strip steel technology, optimization of plastic part process parameters has become one of the hot research in the field of injection molding. This paper takes the automobile front door sill pressure plate as the research object, analysis of optimal gate position and design of three pouring systems by Moldflow, evaluation of each index of the three pouring systems using the integrated scoring method, determines the optimal gating system. Five parameters such as mold temperature and melt temperature were selected as experimental factors, volume shrinkage and warpage are used as evaluation indicators, design and completion of signal-to-noise ratio-based orthogonal tests, determining the optimal combination of process parameters using grey correlation analysis, the results showed that the volume shrinkage and warpage deformation of the two evaluation indexes were reduced by 22.27% and 20.82%, respectively, after optimization. The set of Pareto solutions for volume shrinkage and warping deformation is then obtained by building an Ellipsoidal Basis Function Neural Network (EBFNN) model combined with a Non-dominated Sorting Genetic Algorithm (NSGA-II), and the relatively optimal five sets of Pareto solutions are selected for analysis and comparison, the optimum process parameters were determined as mold temperature 40.5°C, melt temperature 221.4°C, injection time 3.9s, packing pressure 54.8 MPa and packing time 39.s, the maximum volume shrinkage of the optimized part is 5.475%, the warpage deformation is 1.010mm, and the forming quality of the part is improved.
Primary squamous cell carcinoma of the thyroid -case report of a rare disease
Authors: Lévay Bernadett , Kiss Alexandra , Oberna Ferenc , Toth Erika 
Published: March 2023

Abstract
Introduction
Primary squamous cell carcinoma (SCC) of the thyroid gland is a very rare entity. The prognosis is very poor with a short survival time. The aim of this article is to report a case of a SCC of the thyroid gland in a 68-year-old woman, emphasizing how complicate is the operation and the adequate treatment of this disease.
Case report
A 68-year -old woman presented with rapidly growing neck mass with hoarseness and compressive symptoms. Physical examination revealed a hard fixed tumor with right sided vocal cord palsy. Histopathological result confirmed the diagnosis of SCC of the thyroid. PET/CT scan excluded the possibility of other primary malignancies. A surgical intervention was performed, however the patient died in the middle of the palliative radiation therapy.
Conclusion
SCC of the thyroid gland is a great challenge for the surgeon and also for the multidisciplinary team to come up with the best treatment option which is suitable for the patient due to its unfavorable prognosis.
The Effect of RFSSW Parameters on Load Capacity of EN AW-6082-T6 Aluminium Alloy and AlCu Bimetallic Joints
Authors: Kubit Andrzej , Faes Koen , Trzepieciński Tomasz , Żaba Krzysztof , Kaščák Ľuboš 
Published: March 2023

Abstract

In this paper an investigation has been carried out into the creation of Refill Friction Stir Spot Welding (RFSSW) single-lap joints of 6082-T6 aluminium alloy and roll-bonded AlCu bimetallic sheet. The latter sheet comprises aluminium EN AW-1050A and electrolytic copper M1E in Z6 temper condition (after rolling) and with a 1:1 ratio of the Cu:Al layers. The welding parameters involved a variable plunge depth and welding time. The mechanical properties of the joints were determined in tensile/shear tests. The highest average value of the load capacity of the joint was observed in joints made with a tool plunge depth dt = 2.6 mm and total welding time tw = 4 s. The load capacity for this variant was an average of 5986.75 N with standard deviation SD = 166.15 N. A plug type fracture on the aluminium layer of the bimetallic sheet was observed in RFSSW joints produced with a plunge depth of 2.6 mm. Increasing the tool rotational speed, and thus the heat generated, resulted in a plug type fracture on the upper sheet (aluminium alloy). In the case of joints produced with a plunge depth of 2 mm equal to the thickness of upper sheet, the type of fracture mode with both welding times was found to be nugget debonding.
Ambitions for Palliative and End of Life Care: Mapping examples of use of the framework across England
Authors: Borgstrom Erica , Jordan Joanne , Henry Claire 
Published: March 2023

Abstract

Background
Since 2015, the Ambitions for Palliative and End of Life Care: a national framework for local action has provided guidance for care within England and beyond. Relaunched in 2021, the Framework sets out six Ambitions which, collectively, provide a vision to improve how death, dying and bereavement are experienced and managed. However, to date, there has been no central evaluation of how the Framework and its Ambitions have been implemented within service development and provision. To address this evidence gap, we investigated understanding and use of the Framework.
Methods
We reviewed relevant literature and existing information about the Framework and undertook a national (England) online questionnaire survey in order to identify where the Framework has been used; examples of how it has been used; which Ambitions are being addressed; which foundations are being used; understanding of the utility of the Framework; and understanding of the opportunities and challenges involved in its use. Survey responses were analysed both descriptively, using frequency and cross-tabulations, and exploratively, using content and thematic analysis.
Results
Findings indicate that the Framework is particularly relevant to service commissioning and development across wider palliative and end of life care, with most respondents reporting a focus on Ambition 1 (Each person is seen as an individual) and Ambition 3 (Maximising comfort and wellbeing). Additionally, of the Framework foundations, ‘Education and training’ was seen as most necessary to develop and/or sustain reported services. Provision of shared language and collaborative work across sectors and partners were also deemed important. However, there is some indication that the Framework must give more prioritisation to carer and/or bereavement support, have greater scope to enhance shared practice and mutual learning, and be more easily accessible to non-NHS partners.
Conclusions
The survey generated valuable summary level evidence on uptake of the Framework across England, offering important insights into current and past works, the factors impacting on this work and the implications for future development of the Framework. Our findings suggest considerable positive potential of the Framework to generate local action as intended. They also offer a valuable steer for research to further understand the issues raised, as well as scope for additional policy and implementation activity.