bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the effect of educational and counseling intervention via smartphone on awareness and behaviors related to sedentary behavior and consumption of fast foods in women with high body mass index referring to comprehensive health service centers in Urmia in 2022
Authors: gangachin Sayeh Ebrahimi , Bayrami Roghayeh , Rahimi Bahlol , Masudi Sima 
Published: April 2023

Abstract
Background and purpose In addition to causing chronic diseases, overweight and obesity in women of reproductive age lead to fertility problems, adverse pregnancy outcomes, and psychological problems. Among the inappropriate behaviors affecting obesity are the consumption of fast foods and sedentary behaviors, which have the greatest impact on overweight and obesity, and require effective interventions. This study aims to investigate the effect of educational and counseling intervention through smartphone on awareness and behaviors related to sedentary behavior and consumption of fast foods in women referring to comprehensive health service centers in Urmia in 2022.Materials and methods In this experimental study, 106 women of reproductive age covered by comprehensive health service centers were selected by simple random sampling and assigned to two intervention and control groups. The tool used in the researcher-made questionnaire included demographic information, awareness questionnaire about sedentary behaviors and fast foods, questionnaires related to the consumption of fast foods and sedentary behavior. The educational intervention in the intervention group was carried out with a designed application. Data analysis was done with SPSS 20 software at a significance level of P < 0.05.Findings: According to the results of statistical T-TEST, there was a significant difference between the control group and the intervention group in terms of the mean scores of awareness about the consumption of fast foods (P < 0.001) and sedentary behaviors (P < 0.001) before and three months after the intervention. Moreover, the average consumption of fast foods (P < 0.001) and hours of sedentary behavior (P < 0.001) before and three months after the intervention showed a statistically significant difference between the two groups.Conclusion educational and counseling programs with the application can be used both to raise awareness about behaviors related to sedentary behavior and consumption of fast foods and to reduce the consumption of fast foods and behaviors related to sedentary behavior.
Cerebral Palsy – Early Diagnosis and Intervention Trial: Protocol for the Prospective Multicentre CP-EDIT Study with focus on diagnosis, prognostic factors, and intervention
Authors: Hoei-Hansen Christina Engel , Weber Lene , Johansen Mette , Fabricius Rebecca , Hansen Jonas Kjeldbjerg , Viuff Anne-Cathrine F. , Hahn Gitte Holst , Østergaard Elsebet , Duno Morten , Larsen Vibeke Andrée , Madsen Camilla Gøbel , Røhder Katrine , Elvrum Ann-Kristin Gunnes , Laugesen Britt , Ganz Melanie , Madsen Kathrine Skak , Willerslev-Olsen Maria , Debes Nanette Mol , Christensen Jan , Christensen Robin , Rackauskaite Gija 
Published: April 2023

Abstract
Background.
Early diagnosis of cerebral palsy (CP) is important to enable intervention at a time when neuroplasticity is at its highest. Current mean age at diagnosis is 13 months in Denmark. Recent research has documented that an early-diagnosis set-up can lower diagnostic age in high-risk infants. The aim of the current study is to lower diagnostic age of CP regardless of neonatal risk factors. Additionally, we want to investigate if an early intervention program added to standard care is superior to standard care alone.
Methods
The current multicentre study CP-EDIT (Early Diagnosis and Intervention Trial) with the GO-PLAY intervention included (Goal Oriented ParentaL supported home ActivitY program), aims at testing the feasibility of an early diagnosis set-up and the GO-PLAY early intervention. CP-EDIT is a prospective cohort study, consecutively assessing approximately 500 infants at risk of CP. We will systematically collect data at inclusion (age 3-11 months) and follow a subset of participants (n=300) with CP or at high risk of CP until the age of two years. The GO-PLAY early intervention will be tested in 80 infants with CP or high risk of CP.
Focus is on eight areas related to implementation and perspectives of the families: early cerebral magnetic resonance imaging (MRI), early genetic testing, implementation of the General Movements Assessment method, analysis of the GO-PLAY early intervention, parental perspective of early intervention and early diagnosis, early prediction of CP, and comparative analysis of the Hand Assessment for Infants, Hammersmith Infant Neurological Examination, MRI, and the General Movements method.
Discussion
Early screening for CP is increasingly possible and an interim diagnosis of “high risk of CP” is recommended but not currently used in clinical care in Denmark. Additionally, there is a need to accelerate identification in mild or ambiguous cases to facilitate appropriate therapy early. Most studies on early diagnosis focus on identifying CP in infants below five months corrected age. Little is known about early diagnosis in the 50% of all CP cases that are discernible later in infancy. The current study aims at improving care of patients with CP even before they have an established diagnosis.
Trial registration
ClinicalTrials.gov ID 22013292 (reg. date 31/MAR/2023) for the CP-EDIT cohort and ID 22041835 (reg. date 31/MAR/2023) for the GO-PLAY trial.
The clinical significance of initial symptoms in endometriosis-associated ovarian cancer
Authors: Ono Maaya , Fukuda Mayu , Yamanoi Koji , Okunomiya Asuka , Sagae Yusuke , Sunada Masumi , Kitamura Sachiko , Taki Mana , Furutake Yoko , Horie Akihito , Yamaguchi Ken , Hamanishi Junzo , Mandai Masaki 
Published: April 2023

Abstract
Purpose Endometriosis is associated with various symptoms, but their severity varies widely from case to case. In this research we investigated the reality of symptoms presented by patients with clinically early-stage endometriosis-associated ovarian cancer (EAOC), and explored the relationship between symptoms and laboratory/imaging findings, pathological findings and prognosis.Methods This was a retrospective case-control study of patients who received initial surgical treatment and were diagnosed with clinically early-stage EAOC including ovarian endometrioid carcinoma (OEC), ovarian clear cell carcinoma (OCCC), and seromucinous borderline tumor (SMBT). Patients with OEC/OCCC diagnosed between 2006 and 2016, and patients with SMBT diagnosed between 2006 and 2020 were included. Chi-square and Kaplan-Meier estimates were used for statistical analyses.Results A total of 107 patients (OEC, n = 31; OCCC, n = 39; SMBT, n = 37) were included. Fifty-nine (55.1%) patients presented with symptoms, and patients with OEC who presented with symptoms was significantly higher than that of others (OEC, 77.4%; OCCC, 43.6%; SMBT, 48.6%). The details of symptoms differed significantly among pathological types (lower abdominal pain/abdominal discomfort/abnormal bleeding, OEC: 11/8/9; OCCC: 6/12/1; SMBT: 15/5/3). Only in the OEC group, symptomatic patients showed significantly higher white blood cell (WBC) count and neutrophil/lymphocyte (N/L) ratio (symptomatic vs. asymptomatic, median: WBC count: 7250 vs. 5000, p = 0.008; N/L ratio: 4.6 vs. 1.7, p = 0.013). None of the asymptomatic patients showed recurrence during follow-up.Conclusion Patients with EAOC show varying symptoms depending on the histological type of the tumor. Laboratory findings underlying symptoms also vary by histopathological type, which may reflect the difference in carcinogenesis process.
Fracture Resistance of Dental Restorative Fiber-reinforced Composites- A Systematic Review
Authors: Selvaraj Harish , Krithikadatta Jogikalmat , Shrivastava Deepti , Onazi Meshal Aber Al , Algarni Hmoud Ali , Munaga Swapna , Hamza May Othman , Al-fridy Turki Saad , Teja Kavalipurapu Venkata , Janani Krishnamachari , Alam Mohammad Khursheed , Srivast Kumar Chandan 
Published: April 2023

Abstract
Large cavity designs and access cavities impair endodontically treated tooth fracture resistance. As the tooth's strength is known to reduce significantly after the root canal treatment, occlusal loading as a result of functions such as chewing, biting and certain parafunctional tendencies makes the endodontically treated tooth vulnerable to fracture. Hence, after endodontic treatment, it is vital to give adequate and appropriate restorative material to avoid tooth fractures. Accordingly, the choice for such restorative material should be dictated with the property of fracture resistance. The goal of this study was to conduct a systematic review and critical analysis of available data from in vitro studies examining the fracture resistance of endodontically treated teeth repaired with fiber-reinforced composites. A comprehensive literature search was performed using PubMed Central, Medline, Scopus, ScienceDirect, Google Scholar and LILACS. A manual search of the reference lists of the articles was also performed. Two reviewers scrutinized the papers for eligibility based on inclusion/exclusion criteria and extracted data. The studies were assessed for their potential risk of bias. A total of 15 studies met the inclusion criteria and were subsequently analyzed. Based on modified JBI & CRIS (checklist for reporting in vitro studies) guidelines, along with the methodology and treatment objective, we have formulated 13 parameters specifically to study the fracture resistance. The majority of the research had a moderate or high risk of bias. When compared to traditional hybrid composites, fiber-reinforced composites showed increased fracture resistance of endodontically treated teeth in the majority of investigations. On the other hand, limited evidence was found for the bulk fill composites. Moreover, moderate evidence was found for the fracture resistance of inlays and fiber posts with fiber-reinforced composites for core build up in endodontically treated teeth. No evidence could be found comparing the fracture resistance of crowns/endocrowns and fiber-reinforced composites in endodontically treated teeth. According to the research, using fiber-reinforced composites instead of conventional hybrid composites improves the fracture resistance of endodontically treated teeth. However, there was a high risk of bias in the research considered. No judgments could be reached about the superiority of one material over another based on comparisons between other core restorations.
Wogonin preconditioning of MSCs improved their therapeutic efficiency for colitis through promoting glycolysis
Authors: Wu Mengye , Li Cuiping , Zhou Xue , Wu Zhiyong , Feng Jianqi , Guo Xiaolu , Fang Rui , Lian Qinghai , Pan Ming , Lai Xiaorong , Peng Yanwen 
Published: April 2023

Abstract
Inflammatory bowel diseases (IBDs) are prevalent and debilitating diseases with limited clinical treatment strategies. Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal capability and multiple immunomodulatory effects, which make them a promising therapeutic approach for IBDs. Thus, optimization of MSC regimes is crucial for their further clinical application. Wogonin, a flavonoid-like compound with extensive immunomodulatory and adjuvant effects, has been investigated as a potential pretreatment for MSCs in IBD treatment. This research aimed to compare the therapeutic effectiveness of MSCs pretreated with or without wogonin. Compared to untreated MSCs, MSCwogonin (pretreated with wogonin) showed greater effectiveness in the treatment of colitis. Further experiments revealed that wogonin treatment activated the AKT signaling pathway, resulting in higher cellular glycolysis. Inhibition of AKT phosphorylation by perifosine not only decreased glycolysis but impaired the therapeutic efficiency of MSCwogonin. Consistent with these results, qPCR data indicated that wogonin treatment induced the expression of immunomodulatory molecules IL-10, IDO, and AGR1, which were reduced by perifosine. Together, our data demonstrated that wogonin preconditioning strategy further augmented the therapeutic efficacy of MSCs via promoting glycolysis, which should be a promising strategy for optimizing MSC therapy in IBDs.
Effect of Social Distancing Period on Oral Health Related Quality of Life in Shanghai: a representative cross-sectional study
Authors: Wang J , Hu XY , Shi JF , Xu JN , Fu YY , Chen D , Shi WT , Jiang Xinquan 
Published: April 2023

AbstractBackgroundThe coronavirus disease 2019 (COVID-19) pandemic has led to many visible public health responses and significant restrictions on society, but its implications for oral health-related quality of life (OHRQoL) is relatively unknown. The present study investigated the association between the social distancing period and oral health-related quality of life (OHRQoL) in Shanghai.MethodsFrom July 9th to July 22nd, 2022 in Shanghai, 5,041 participants were recruited and completed a survey on demographic data, oral manifestations, oral hygiene practices, and a 14-item version of the Oral Health Impact Profile (OHIP-14) during the past social distancing periods. After multivariate adjustment of covariates, the logistic regression analysis was fitted to estimate the odds ratio (OR) and 95% confidence interval (95% CI) to evaluate the association between the longevity of social distancing and the OHIP-14 scores increment. Causal mediation analysis was employed to evaluate the extent to which oral hygiene practices, oral symptoms, and weight change mediate the association of detrimental OHRQoL with the social distancing period.ResultsThe OR of OHIP-14 increment was largely unchanged with the selection of confounding factors adjusted, which is 1.26 (95% CI, 1.04–1.53) in one month, 1.33 (95% CI, 1.08–1.65) in one and a half months, 1.29 (95% CI, 1.03–1.61) in two months and 1.83 (95% CI, 1.51–2.22) in more than two months, compared to that in half a month respectively. The proportion mediated by rinsing frequency was 18.88% (95% CI, 3.73%-34.04%) in one month, 19.08% (95% CI, 3.65%-34.051%) in one and a half months, 41.3% (95% CI, 9.61%-72.98%) in two months, and 66.41% (95% CI, 50.07%-82.76%) in more than two months, respectively.ConclusionOur findings showed a detrimental OHRQoL during the prolonged social distancing period due to the COVID-19 pandemic. Policies approaching enhanced oral hygiene practices, especially rinsing serve as a protection of OHRQoL in the pandemic.
A structural approach to detecting opinion leaders in Twitter by Random Matrix Theory
Authors: Mohammadi Saeedeh , Moradi Parham , Trufanov Andrey , Jafari G.Reza 
Published: April 2023

Abstract
Social media is now one of the primary channels for consuming news. As a result, political figures and activists are increasingly using social media to push their interests. So, users who are influential in trends gain a lot of weight since they may change the narrative of the conversation. In this study, we employ random matrix theory to identify these influential users of Twitter in the 2021 Iranian presidential election. According to our research of trending hashtags, the most prominent people, in this case, were actually bots, showing the existence of coordinated and deceitful operations. Furthermore, we indicate which community has these leaders, implying that a specific community controls the trend of these hashtags. As a test case for our methodology, we use Twitter's popular hashtags for the Iranian presidential election in 2021.
Synthesis and Characterization of Shape Memory Poly (ε-caprolactone) networks with Programmable and Reconfigurable Shape-Morphing Behaviors
Authors: tian guangming , Zhao Shuo , Pan Longkai , Yang Dong , Ma Jianhua 
Published: April 2023

Abstract
Poly(ε-caprolactone) (PCL)-based semi-crystalline polymer are shape memory materials that has been extensively used in the biomedical field. Despite the large number of studies aimed at constructing the well-defined crosslinked polymer networks, detailed investigations of properties in terms of structural factors at the molecular level that influence the thermal-mechanical and shape memory properties are still poorly understand and investigated. In this work, PCL crosslinked networks with different molecular weight of diacrylate PCL prepolymers (Mn) are prepared via base-catalyzed Michael addition. The results indicate that the overall melting temperature, the crystallization temperature and the crystallinity of the networks exhibit an upward trend with increment of Mn. Besides that, the tensile strength and shape memory performance are also correlated with Mn. Controlled-strain DMA characterization on shape memory properties show that the cPCL-10000 network exhibits the most remarkable shape fixity and shape recovery ratio, indicative of lowering cross-linking density and chains mobility. In particular, editable shape memory properties can also be achieved by triggering transesterification within the same polymer network, and a possible molecular mechanism responsible for the elasticity-based shape memory effect and plasticity-based permanent shape reconfigurability is proposed and combined to present the shape-morphing behaviors.
Intraoperative serum lactate levels as a prognostic predictor of outcome for emergency abdominal surgery: a retrospective study
Authors: Sugita Shinji , Ishikawa Masashi , Sakuma Takahiro , Iizuka Masumi , Hanai Sayako , Sakamoto Atsuhiro 
Published: April 2023

Abstract
BACKGROUND The relationship between intraoperative lactate levels and prognosis after emergency gastrointestinal (GI) surgery remains unclear. The purpose of this study was to investigate the prognostic value of intraoperative lactate levels for predicting in-hospital mortality, and to examine intraoperative hemodynamic managements.METHODS. We conducted a retrospective observational study of emergency GI surgeries performed at our institution between 2011 and 2020. The study group comprised patients admitted to intensive care units postoperatively, and whose intraoperative and postoperative lactate levels were available. Intraoperative peak lactate levels (Intra-LACs) were selected for analysis, and in-hospital mortality was set as the primary outcome. The prognostic value of intra-LAC was assessed using logistic regression and receiver operating characteristic (ROC) curve analysis.RESULTS. Of the 551 patients included in the study, 120 died postoperatively. Intra-LAC in the group who survived and the group who died was 1.56 [interquartile range [IQR], 1.03–2.64] mmol/L and 3.46 [IQR, 1.84–6.26] mmol/L (P < 0.001), respectively. The patients who died had larger volumes of red blood cell (RBC) transfusions and fluid administration, and were administered higher doses of vasoactive drugs. Logistic regression analysis showed that intra-LAC was an independent predictor of postoperative mortality (odds ratio [OR] 1.21, 95% CI 1.07–1.36, P = 0.002). The volume of RBCs, or fluids transfused, or the amount of vasoactive agents administered were not independent predictors. The area under the curve (AUC) of the ROC curve for intra-LAC for in-hospital mortality was 0.762 (95% confidence interval [CI], 0.71–0.81), with a cutoff value of 3.68 mmol/L by Youden index.CONCLUSIONS. The intraoperative lactate level but not hemodynamic managements was an independently associated with increased in-hospital mortality after emergency GI surgery.
Magnetic resonance-guided focused ultrasound thalamotomy rebalances atypical functional hierarchy in patients with Essential Tremor
Authors: Lin Jiaji , Kang Xiaopeng , Lu Haoxuan , Zhang Dekang , Bian Xianbing , Zhou Jiayou , Hu Jianxing , Zhang Dong , Sepulcre Jorge , Pan Longsheng , Lou Xin 
Published: April 2023

Abstract
Magnetic resonance-guided focused ultrasound (MRgFUS) has brought thalamotomy back to the frontline for Essential Tremor (ET). As functional organization of human brain strictly follows hierarchical principles which are frequently deficient in neurological diseases, whether additional damage from MRgFUS thalamotomy induces further disruptions of ET functional scaffolds are still controversial. This study was to examine the alteration features of brain functional frameworks following MRgFUS thalamotomy in patients with Essential Tremor (ET). We retrospectively obtained preoperative (ETpre) and postoperative 6-month (ET6m) data of 30 ET patients underwent MRgFUS thalamotomy from 2018 to 2020. Their archived functional MR images were used to functional gradient comparison. Both supervised pattern learning and stepwise linear regression were conducted to associate gradient features to tremor symptoms with additional neuropathophysiological analysis. MRgFUS thalamotomy relieved 78.19% of hand tremor symptoms and induced vast global framework alteration (ET6m vs. ETpre: Cohen d = -0.80, P < 0.001). Multiple robust alterations were identified especially in posterior cingulate cortex (ET6m vs. ETpre: Cohen d = 0.87, P = 0.048). Compared with matched health controls (HCs), its gradient distances to primary communities were significantly increased in ETpre patients with anomalous stepwise connectivity (P < 0.05 in ETpre vs. HCs), which were restored after MRgFUS thalamotomy. Both global and regional gradient features could be used for tremor symptom prediction and were linked to neuropathophysiological features of Parkinson disease and oxidative phosphorylation. MRgFUS thalamotomy not only suppress tremor symptoms but also rebalances atypical functional hierarchical architecture of ET patients.
Estimating the Percentage Mediation of Ict Utilisation on Information Literacy and Mathematics Performance in Colleges of Education, Ghana
Authors: Kumah Maxwell 
Published: April 2023

Abstract
Introduction: Student teachers’ (ST) mathematics performance (MP) is still an issue of concern in college. Meanwhile, ICT integration and utilisation has been a policy for almost a decade. This is to enable tertiary learners to breakthrough learning struggles particularly in mathematics.
Aim: This paper aims to model the relationship between student teachers’ interest in information literacy (IIL) and MP moderated by ICT utilisation (ICTU).
Methods: Analytic survey design was adopted using IIL and ICTU Questionnaire and Mathematics Achievement Test (MAT) to collect data. Level 200 student teachers were purposely selected with a random sampling technique to obtain 526 student teachers from two Colleges of Education in the Hohoe Municipality, Volta region.
Result:It was revealed that, majority 138 (26.2%) had moderate interest in IIL while only 47(8.9%) of them were extremely interested. Similarly, the majority 135(25.7%) indicated that ICTU was somewhat helpful while only 41(7.8%) expressed that it was very helpful. There was no significant influence of gender and programs of study on MP. There was a significant positive correlation between ICTU and IIL and for MP and IIL, there was a significant inverse correlation directly. The result also shows that in IIL inversely predict student teachers’ MP relationship but not moderated by ICTU.
Conclusion: The findings suggest that student teachers who show high interest in IL are more likely to perform less in mathematics and vice versa.