bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unsupervised Framing Analysis for Social Media Discourse in Polarizing Events
Authors: Sarmiento Hernan , Córdova Ricardo , Ortiz Jorge , Bravo-Marquez Felipe , Santos Marcelo , Valenzuela Sebastián 
Published: January 2025

This study investigates the concept of
frames
in the realm of online polarization, with a focus on social media platforms. The research extends the understanding of how frames—emerging, complex, and often subtle concepts—become prominent in online conversations that are polarized. The study proposes a comprehensive methodology for identifying and characterizing these frames, integrating machine learning techniques, network analysis algorithms, and natural language processing tools. This method aims for generalizability across multiple platforms and types of user engagement. Two novel metrics,
homogeneity
and
relevancy
are introduced for the rigorous evaluation of identified frame candidates.

Grounded in several foundational presumptions, including the role of topics and multi-word expressions in framing, the study sheds light on how frames emerge and gain significance within digital communities. The research questions explored include the methods for identifying frames, the variability and significance of these frames, and the effectiveness of different computational techniques in this context.
To validate the approach, we present a case study of the 2021 Chilean presidential election, using data from both Twitter and WhatsApp platforms. This real-world application allows for the examination of how frames fluctuate in response to events and the specific mechanisms of platforms. Overall, the study makes several key contributions to the field, offering new insights and methodologies for analyzing the complexities of online polarization. It serves as groundwork for future research on the dynamics of online communities, especially those associated with distinctly polarized events.
Optical Fiber Mediated Biosensors for Multiplex and Onsite Food Safety Analysis: A Review
Authors: Hameed Sara , Naz Iram , Badea Mihaela , Bano Nargis , Andreescu Silvana , hayat akhtar , Jubeen Farhat 
Published: January 2025

Abstract
The presence of unsafe levels of chemical compounds, toxins, and pathogens in food poses a serious threat to public health, especially in economically disadvantaged countries. Current detection methods are costly, require centralized labs, skilled personnel, and specialized equipment, hindering large-scale testing. Here we provide a comprehensive review of optical fiber (OF)-based biosensors for multiplex detection of analytes in food. It covers fiber modification strategies to enhance multiplexing capacity by incorporating multiple independent detection regions. The review classifies OF multiplexing detection principles into label and label-free approaches for antibody and aptamer-based biosensing, comparing their characteristics and applications in food matrices. Despite challenges like multiplexing capacity and complex instrumentation, the review outlines promising prospects for achieving portable, rapid, accurate, and intelligent multiplexing for food safety.
Storylines of Unprecedented Extremes in the Southeast United States
Authors: Masukwedza Gibbon Innocent Tirivanhu , Clark Jenna , Jaffe Amy , Jeffries Ivy , Tietjen Bethany , de Perez Erin Coughlan 
Published: January 2025

Abstract
Disaster planning based on historical events is like driving forward while only looking in the rear-view mirror. To expand our field of view, we use a large ensemble of weather simulations to characterise the current risk of extreme weather events in case study locations in the Southeastern United States. We find that extreme temperature events have become more frequent between 1981 and 2021, and heavy precipitation events are also more frequent in the wettest months. Combining a historical analysis of people’s recent experience with the rate of change of extreme events, we define four quadrants that apply to groups of case studies: Sitting Ducks”, “Recent Rarity”, “Living Memory”, and “Fading Memory”. A critical storyline is that of the “Sitting ducks”: locations where we find a high rate of increase in extreme events and where the most extreme event in recent memory (1981-2021) has a low return period in today’s climate. We find that these locations have a high potential for surprise. For example, in Montgomery County, Alabama, the most extreme temperature event since 1981 has a return period of 13 years in the climate of 2021. In these places, we offer unprecedented synthetic events from the large ensemble for use in disaster preparedness simulations to help people imagine the unprecedented. Our results not only document substantial changes in the risk of extremes in the Southeastern United States but also propose a generalizable framework for using large ensembles in disaster preparedness simulations in a changing climate.
The Long Lives of Subducted Spice and Vorticity Anomalies in the Subtropical Oceans
Authors: Hersh Cora , Wijffels Susan , Gebbie Geoffrey , Forget Gaël 
Published: January 2025

Abstract
Subtropical cells, which exist in nearly all ocean basins, connect subducting subtropical waters to upwelling sites along the equator. This tight link between the subtropics and the tropics, on a scale of 5–15 years, is well established in a time-averaged sense by modeling and observations. Recently, evidence has emerged of spice and potential vorticity anomaly persistence along mean flow pathways on isopycnals. We provide the first global view of subtropical water mass anomaly propagation, using both an observational dataset and the Estimating the Circulation and Climate of the Ocean (ECCO) state estimate version 4 release 4. In this global synthesis that complements the existing body of largely regional studies, we find long-lived interannual water mass anomalies that translate along mean advective pathways in all ventilated subtropical gyres. They are detectable over multiple years and several thousand kilometers. Some anomalies are persistent enough to reach both the western boundary and equatorial current systems before being entirely eroded and thus could form ocean “tunnels” equivalent to the well-studied atmospheric bridge to impact the remote climate variability. The analysis of ocean tunnel propagation of a passive tracer (spice) and an active tracer (potential vorticity) confirms earlier model results that the active tracer decays more quickly than the passive tracer. Similarities and differences between timing and frequency of the two tracers could provide clues to anomaly formation mechanisms in various subduction regions. The success of ECCO in capturing these phenomena is encouragement to further explore their upstream sources and downstream impacts within this framework.

Significance Statement
Surface waters in the subtropical oceans flow below the surface layer and travel for long distances westward and equatorward until they reemerge at the surface. It is known that average water properties can persist for thousands of kilometers along this “ocean tunnel,” but how much the year-to-year variability can survive without being mixed away is less understood. We use observational data and global model output to estimate the frequency and survival of interannual anomalies of water properties along ocean tunnels. We find that such anomalies are common in all subtropical basins, that they have the potential to persist until they reach the tropics, and that the global model captures the variability seen in observations.
SFY—A Lightweight, High-Frequency, and Phase-Resolving Wave Buoy for Coastal Waters
Authors: Hope Gaute , Seldal Torunn Irene , Rabault Jean , Bryhni Helge Thomas , Bohlinger Patrik , Björkqvist Jan-Victor , Nordam Tor , Kleven Atle , Mostaani Arsalan , Furevik Birgitte Rugaard , Hole Lars Robert , Storvik Roger , Breivik Øyvind 
Published: January 2025

Abstract
Small lightweight wave buoys, designed to operate near the coast, have been developed. The buoys are designed to record and transmit the full-time series of surface acceleration at 52 Hz. The buoy uses the cellular network to transfer data and position (up to 80 km from the base station). This reduces costs and increases bandwidth. The low cost and low weight permit the buoys to be deployed easily and in arrays in areas where satellite and wave models struggle to resolve wave and current interaction. The buoys are tested in a wave flume, the open water, and the breaking waves of the surf. The conditions range from calm to significant wave heights exceeding 7 m and crashing breakers with accelerations exceeding 10g. The high sample rate captures the impulse of breaking waves and allows them to be studied in detail. Breaking waves are measured and quantified in the open water. We measure breaking waves in the surf and recover the trajectory of waves breaking in the field to a higher degree than previously done. The time series of surface elevation, and accurate positioning, permits the signal of adjacent buoys to be correlated in a coherent phase-resolved way. Finally, we offer an explanation and solution for the ubiquitous low-frequency noise in inertial measurement unit (IMU)–based buoys and discuss the necessary sampling and design to measure the areas of breaking waves.
EXPRESS: Lower Artificial Intelligence Literacy Predicts Greater AI Receptivity
Authors: Tully Stephanie , Longoni Chiara , Appel Gil 
Published: January 2025

As artificial intelligence (AI) transforms society, understanding factors that influence AI receptivity is increasingly important. The current research investigates which types of consumers have greater AI receptivity. Contrary to expectations revealed in four surveys, cross country data and six additional studies find that people with lower AI literacy are typically more receptive to AI. This lower literacy-greater receptivity link is not explained by differences in perceptions of AI’s capability, ethicality, or feared impact on humanity. Instead, this link occurs because people with lower AI literacy are more likely to perceive AI as magical and experience feelings of awe in the face of AI’s execution of tasks that seem to require uniquely human attributes. In line with this theorizing, the lower literacy-higher receptivity link is mediated by perceptions of AI as magical and is moderated among tasks not assumed to require distinctly human attributes. These findings suggest that companies may benefit from shifting their marketing efforts and product development towards consumers with lower AI literacy. Additionally, efforts to demystify AI may inadvertently reduce its appeal, indicating that maintaining an aura of magic around AI could be beneficial for adoption.
“Together is no longer completely together”: Exploring the influence of social cognition problems on partner relationships following acquired brain injury
Authors: van den Broek Brenda , Muskens Jorn , van Heugten Caroline , Bus Boudewijn , Rijnen Sophie 
Published: January 2025

Objective To examine the experiences of individuals with acquired brain injury and their partners regarding the effects of social cognition problems on their relationships. Design Qualitative interview study. Setting Interviews were conducted 1 to 5 years post-injury, either in the participants’ home or at a care facility in the Netherlands. Participants Nine couples consisting of an individual with acquired brain injury and a partner without acquired brain injury. Scores on neuropsychological tests indicated social cognition difficulties in individuals with acquired brain injury. Methods Individual semi-structured interviews were conducted, audio recorded, and transcribed verbatim. Two independent analysts analyzed the data using thematic analysis aimed at finding common themes across the data set. Data analysis was carried out recursively and parallel to data collection to help determine when saturation was reached. Results Six themes were generated from the interview data: (1) partners feeling disappointed, lonely, and despondent, (2) individuals with acquired brain injury feeling insecure and ashamed of falling short, (3) relationship roles changing, (4) the aggravating role of fatigue and sensory hypersensitivity, (5) the importance of professional help, and (6) silver linings: increased awareness creating closeness. Conclusion Social cognition problems have the potential to strongly affect relationships between those with acquired brain injury and their partners in many ways. Addressing social cognition problems is recommended as it is greatly appreciated by individuals with acquired brain injury and their partners and holds promise for improving their relationship.
The Pharmacological Research of Traditional Chinese Medicine and Herbal Remedies in the Treatment of Melanoma
Authors: Yan Shuang , Wang Yawei , Zeng Jing , Liu Dan , Qin Haichuan , Du Chengzhen , Xiang Qiao , Yang Li , Li Ling , He Yuxin 
Published: January 2025

Background: Melanoma is a highly invasive and metastatic malignant tumor, with pathogenesis involving multiple signaling pathways and transcription factors. Current treatments face significant challenges, including drug resistance, toxic side effects, and recurrence. Purpose: This review aims to evaluate the therapeutic potential of natural products in the treatment of melanoma and to identify the associated challenges and future research opportunities. Methods: A comprehensive literature search was conducted using PubMed and Web of Science to identify studies reporting on natural products with antimelanoma activity. Results: Natural products demonstrate diverse pharmacological activities, including antiproliferative, proapoptotic, and antimetastatic effects, highlighting their potential in melanoma treatment. However, challenges such as limited efficacy, safety concerns, and the lack of standardized formulations remain significant barriers. Conclusion: This review provides insights into the therapeutic applications of natural products for melanoma, discusses existing limitations, and proposes future directions, contributing to the development of effective and safe antimelanoma treatments.
Development and Validation of a Robust LC-MS/MS Method for Quantitation of a Novel Kinase Inhibitor, Ritlecitinib, in Rat Plasma: Application in Pharmacokinetic Study
Authors: Kumar Katari Pavan , Rao Areti Anka 
Published: January 2025

Background Ritlecitinib (RIT) is a novel kinase inhibitor with promising therapeutic applications in the treatment of autoimmune disease alopecia areata. Accurate quantification of RIT in biological matrices is essential for pharmacokinetic studies and drug development. Objectives This study aims to develop and validate a sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitation of RIT in rat plasma and to apply this method in a pharmacokinetic study. Materials and Methods A sensitive and selective LC-MS/MS method was developed in a AB Sciex QTRAP 5500 coupled with Shimadzu Prominence LC-20AD UFLC (ultra-fast liquid chromatography) System using an C18 column (Xselect HSS T3 2.5 µm, 2.1x150 mm) with a mobile phase consisting of 0.1% formic acid in high-performance liquid chromatography (HPLC) grade water and 0.1% formic acid in acetonitrile (70:30, v:v). RIT ( m/z 286.1 ↓ 105.7) and [ 13 C4]-ritlecitinib (internal standard, IS) ( m/z 290.1 ↓ 109.7) were detected in a positive mode by electrospray ionization (ESI) using multiple reaction monitoring (MRM) and extracted from rat plasma samples through protein precipitation We validated the method according to United States Food and Drug Administration (U.S. FDA) guidelines, assessing parameters such as linearity, accuracy, precision, selectivity, sensitivity, recovery and stability. The validated method was then applied to a pharmacokinetic study in rats following the administration of RIT. Results On rat plasma, the LC-MS/MS method has shown exceptional linearity across the concentration range of 5–100 ng/mL. The FDA’s approved standards of ±15% matched the accuracy and precision measurements. The matrix effect was negligible, and the mean recovery was about 93%, indicating that RIT was fully extracted from plasma. Different experimental conditions found RIT to be stable. RIT is quickly absorbed, with a peak plasma concentration (Cmax) of 43.82 ng/mL occurring 0.5–0.75 hours after the dose. It then drops in concentration in a way that is biexponential, with a half-life at the end of 1.5 hours. Conclusion A highly sensitive and specific LC-MS/MS method for quantitation of RIT in rat plasma was successfully developed and validated. The method was effectively applied to a pharmacokinetic study, providing critical data on the absorption and elimination characteristics of RIT in rats. This established approach may support additional preclinical pharmacokinetic investigations of RIT.
Benzoxazinone Derivatives as Antiplatelet: Synthesis, Molecular Docking, and Bleeding Time Evaluation
Authors: Nofianti Kholis Amalia , Ekowati Juni , Diyah Nuzul Wahyuning , Hakim Luqmanul 
Published: January 2025

Background The recurrence of atherosclerosis is still a global problem. Unfortunately, the drugs currently being used are reported to have resistance. Purpose To prevent the recurrence of atherosclerosis disease, this study developed benzoxazinone derivatives as an antiplatelet agent: 2-phenyl-3,1-benzoxazine-4-one (BZ1) and 2-(4′-chlorophenyl)-3,1-benzoxazin-4-one (BZ2). Methods The target compounds were synthesized through acyl nucleophilic substitution from acyl chloride and anthranilic acid using a base catalyst in triethylamine. This compound was then given to mice at three different doses to perform bleeding-time and clotting-time tests, using acetosal as a comparison. In silico, the binding energy between the test compound and the cyclooxygenase 1 enzyme was tested using Molegro Virtual Docker version 5.5 (MVD 5.5). The pharmacokinetic parameters were predicted using pharmacokinetics and chemistry through space mapping (pkCSM). Results The synthesis provided 83% yield. The biological assay at a dose of 20 mg/kg body weight (BW) BZ1 showed a higher bleeding time (361 s) than acetosal (324 s), whereas BZ2 was lower (179 s). The molecular analysis revealed that the compound had higher activity than aspirin. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) showed that the compound posed high intestinal absorption. Conclusion This research concluded that both of the synthesized compounds have the potential and prospective to be developed as antiplatelet agents.
Continuous versus intermittent tacrolimus for graft-versus-host disease prophylaxis in pediatric hematopoietic stem cell transplantation patients (Tic Tac)
Authors: Asleson Demi , Carr Roxane , Rozmus Jacob , Kendrick Jennifer 
Published: January 2025

Background Tacrolimus is administered via a continuous or intermittent IV infusion to prevent acute graft versus host disease (aGvHD) in pediatric hematopoietic stem cell transplant (HSCT) recipients. Limited comparison data is available. Objectives The primary objective was to compare the proportion of therapeutic tacrolimus trough levels in the first 30 days post-stem cell infusion. Secondary outcomes were prevalence of aGvHD, intra-patient variability (IPV) and safety. Study Design This was a retrospective cohort study that included pediatric HSCT recipients between March 1, 2015 and October 31,2021 at BC Childrens Hospital. Adverse events were assessed using the Naranjo scoring tool. Results Overall, 60 transplants in 59 patients were included; n = 36 intermittent IV and n = 24 continuous IV. Median proportion of blood levels (intermittent and continuous) within 8–12 ug/L was 38% and 56%, respectively (p = 0.04). IPV was 33% and 31% and aGvHD was 39% and 38% in intermittent and continuous respectively. There was a higher proportion of adverse effects in the intermittent group with the exception of hypomagnesemia. Conclusions Continuous IV tacrolimus provided a higher proportion of levels within therapeutic range. Neither achieved therapeutic trough levels in more than 56% of transplants. However, there was large intra-patient variability in both groups.
A cognitive help or hindrance? A systematic review of cognitive behavioural therapy to treat anxiety in young people with autism spectrum disorder
Authors: Roberts K. , Rankin P. M. 
Published: January 2025

Objective Anxiety rates amongst autistic youth range from 11% to 84%. While Cognitive Behavioural Therapy (CBT) is an effective treatment of anxiety in neurotypical youth, there are concerns autistic youth lack the cognitive resources necessary to effectively engage with CBT. It is also unclear whether standard or adapted CBT is more effective. This review aims to compare the effects of standard and adapted CBT in the treatment of anxiety in autistic youth. Methods Articles were searched across three online databases. 24 articles were selected for final review. All articles were published between 2008 and 2024. Total sample size was 1,140 and participant age ranged from 4–18 years. Various designs, settings, and CBT formats were incorporated. Results When treating anxiety in autistic youth, standard CBT is effective although CBT adapted to accommodate the autism-related needs of the youth appears more effective, with gains maintained up to 26 months post-treatment. Statistical analysis was not significant. Conclusions Standard and adapted CBT are effective treatments of anxiety in autistic youth. To optimise outcomes, it may be important to consider the common cognitive styles associated with autism and adapt the therapeutic intervention accordingly. However, there is not yet statistical evidence for this hypothesis.
Children and divorce: A rapid review targeting cognitive dissonance, in the context of narrative therapy
Authors: Lie Ken Jie Christopher , Jessen Yramategui Joanne , Huang Richard 
Published: January 2025

Today, for divorcing parents, the social norms of “good” parenting appear to impose obligations to “fight” for shared custody of their children. However, this may intensify conflicts experienced by their children in the form of cognitive dissonance. Authors conducted a rapid review to explore children’s experiences of divorce (ages three to 12 years old) in the context of narrative therapy, in order to uncover the mechanism of cognitive dissonance. Four databases of Scopus, PsychINFO, Family and Societies Studies Worldwide, and PubMed were searched for literature in the last 10 years. Results included 11 study articles, one policy brief, and one book chapter, representing the experiences of 1169 children from seven developed countries/regions. Our findings suggest four themes associated with cognitive dissonance, whereby the first three represent the formation of harmful perceptions of cognitive dissonance resulting from divorce. The fourth represents the children’s coping strategies to reduce their cognitive dissonance. We advocate that family mediators consider narrative therapy targeting cognitive dissonance as a means of repairing disruptions to family coherence. In this regard, we recommend that future research explore the consequences of children’s confrontation of their cognitive dissonance in narratives found to be prevalent in children’s experiences of divorce.