bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single Cross-Sectional Analysis; Post-Myocardial Infarction Instrumental & Laboratory changes in Prognosis Behavior
Authors: Marzoog Basheer Abdullah , Bloshkina Natalia Igorevna , Gromova Vera Sergeevna , Vanichkina Ekaterina , Gorshinina Elena Ivanovna 
Published: February 2023

AbstractBackgroundCardiovascular events remain one of the frequently reported causes of death globally.AimsAssess the early laboratory and instrumental changes in systemic manner in patients with myocardial infarction (MI).ObjectivesPatients with fresh myocardial infarction that has been occurred in less than 30 days before hospitalization in the rehabilitation hospital.Materials and methodsA single large-scale retrospective cohort sectional study for patients with fresh myocardial infarction for the period 2014-2019, data collected from Mordovia Rehabilitation Hospital. The study involved 154 patients and analysed 76 parameters for each patient. The t test, Pearson’s correlation coefficient, and ROC test have been used. For statistical analysis used Statistica program.ResultsThe sample included 154 patients with a history of fresh myocardial infarction. Of 154. 51(33.11%) female and 103 (66.88 %) males. Chronic heart failure (CHF), which is seen in 42 (27.27 %) patients, 101 (65.58 %) did not have CHF and 11 (7.142 %) missing data. Diabetes mellitus (DM) has been observed in 28 (18.18182 %), 118 (76.62 %) without DM, Hypertension has been seen in 118 (76.62 %), 28 (18.18 %) did not have hypertension, chronic kidney disease (CKD) has been seen in 11 (7.14%) patients, 131 (85.064 %) did not have CKD, Chronic obstructive pulmonary disease (COPD) existed in 14 (9.09 %), 132 (85.71 %) did not have COPD. Post myocardial infarction (MI) CHF has been observed in 108 (70.12987%), 42 (27.27 %) did not have CHF. Post MI arrythmia seen in 50 (32.47%) patients, 99 (64.28 %) did not have arrythmia. Early post MI complication such as aneurysm has been seen in 12 (7.79 %), 138 (89.61 %) did not have aneurysm, Dressler syndrome; pericarditis has been seen in 4 (2.59 %) patients, pneumonitis seen in 1 (0.64 %) patient, and pleuritis have not been seen.ConclusionsSystemic manifestations include kidney function impairment or development of new kidney disease. These changes include an increase in the aorta basement diameter, an increase in the right ventricle size, a decrease in the level of serum red blood cells, the serum potassium level, and serum calcium level, with an increase in the serum myoglobin. The high myoglobin level is associated with the development of chronic heart failure. The higher creatinine level and or LDH is associated with arrythmia development. Hypertension is the predominant concomitant disease in victims of MI. And arrythmia is most commonly reported post-MI complication.OthersFemales are more frequently affected by post-MI urinary tract infection.
Cerebellar Granule Cells Develop Non-neuronal 3D Genome Architecture over the Lifespan
Authors: Tan Longzhi , Shi Jenny , Moghadami Siavash , Wright Cydney P. , Parasar Bibudha , Seo Yunji , Vallejo Kristen , Cobos Inma , Duncan Laramie , Chen Ritchie , Deisseroth Karl 
Published: February 2023

AbstractThe cerebellum contains most of the neurons in the human brain, and exhibits unique modes of development, malformation, and aging. For example, granule cells—the most abundant neuron type—develop unusually late and exhibit unique nuclear morphology. Here, by developing our high-resolution single-cell 3D genome assay Dip-C into population-scale (Pop-C) and virus-enriched (vDip-C) modes, we were able to resolve the first 3D genome structures of single cerebellar cells, create life-spanning 3D genome atlases for both human and mouse, and jointly measure transcriptome and chromatin accessibility during development. We found that while the transcriptome and chromatin accessibility of human granule cells exhibit a characteristic maturation pattern within the first year of postnatal life, 3D genome architecture gradually remodels throughout life into a non-neuronal state with ultra-long-range intra-chromosomal contacts and specific inter-chromosomal contacts. This 3D genome remodeling is conserved in mice, and robust to heterozygous deletion of chromatin remodeling disease-associated genes (Chd8orArid1b). Together these results reveal unexpected and evolutionarily-conserved molecular processes underlying the unique development and aging of the mammalian cerebellum.
Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons to suppress feeding
Authors: Alvarado Jonnathan Singh , Lutas Andrew , Madara Joseph C. , Isaac Jeremiah , Lommer Caroline , Andermann Mark L. 
Published: February 2023

AbstractBrief stimuli can trigger longer lasting brain states. G protein-coupled receptors (GPCRs) could help sustain such states by coupling slow-timescale molecular signals to neuronal excitability. Brainstem parabrachial nucleus glutamatergic neurons (PBNGlut) regulate sustained brain states such as pain, and express Gs-coupled GPCRs that increase cAMP signaling. We asked whether cAMP directly influences PBNGlutexcitability and behavior. Both brief tail shocks and brief optogenetic stimulation of cAMP production in PBNGlutneurons drove minutes-long suppression of feeding. This suppression matched the duration of prolonged elevations in cAMP, Protein Kinase A (PKA), and calcium activityin vivoandin vitro.Shortening this elevation in cAMP reduced the duration of feeding suppression following tail shocks. cAMP elevations in PBNGlutneurons rapidly lead to sustained increases in action potential firing via PKA-dependent mechanisms. Thus, molecular signaling in PBNGlutneurons helps prolong neural activity and behavioral states evoked by brief, salient bodily stimuli.
Control of human pancreatic beta cell kinome by GLP-1R biased agonism
Authors: Xiao Jiannan , Eid Liliane El , Buenaventura Teresa , Boutry Raphaël , Bonnefond Amélie , Jones Ben , Rutter Guy A , Froguel Philippe , Tomas Alejandra 
Published: February 2023

AbstractAimTo determine the kinase activity profiles of human pancreatic beta cells downstream of GLP-1R balancedversusbiased agonist stimulations.Materials and methodsThis study analysed the kinomic profiles of human EndoC-βh1 cells following vehicle and glucagon-like peptide-1 receptor (GLP-1R) stimulation with the pharmacological agonist exendin-4, as well as exendin-4-based biased derivatives exendin-phe1 and exendin-asp3 for acute (10-minute)versussustained (120-minute) responses, using PamChip® protein tyrosine kinase (PTK) and serine/threonine kinase (STK) assays. The raw data were filtered and normalised using BioNavigator. The kinase analyses were conducted with R, mainly including kinase-substrate mapping and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.ResultsThe present analysis reveals that kinomic responses are distinct for acuteversussustained GLP-1R agonist (GLP-1RA) exposure, with individual responses associated with agonists presenting specific bias profiles. According to pathway analysis, several kinases, including JNKs, PKCs, INSR and LKB1, are important GLP-1R signalling mediators, constituting potential targets for further research on biased GLP-1R downstream signalling.ConclusionResults from this study suggest that differentially biased exendin-phe1 and exendin-asp3 can modulate distinct kinase interaction networks. Further understanding of these mechanisms will have important implications for the selection of appropriate anti-T2D therapies with optimised downstream kinomic profiles.
A frontosensory circuit for visual context processing is synchronous in the theta/alpha band
Authors: Bastos Georgia , Holmes Jacob T. , Ross Jordan M. , Rader Anna M. , Gallimore Connor G. , Peterka Darcy S. , Hamm Jordan P. 
Published: February 2023

AbstractVisual processing is strongly influenced by context. Stimuli that deviate from contextual regularities elicit augmented responses in primary visual cortex (V1). These heightened responses, known as “deviance detection,” require both inhibition local to V1 and top-down modulation from higher areas of cortex. Here we investigated the spatiotemporal mechanisms by which these circuit elements interact to support deviance detection. Local field potential recordings in mice in anterior cingulate area (ACa) and V1 during a visual oddball paradigm showed that interregional synchrony peaks in the theta/alpha band (6-12 Hz). Two-photon imaging in V1 revealed that mainly pyramidal neurons exhibited deviance detection, while vasointestinal peptide-positive interneurons (VIPs) increased activity and somatostatin-positive interneurons (SSTs) decreased activity (adapted) to redundant stimuli (prior to deviants). Optogenetic drive of ACa-V1 inputs at 6-12 Hz activated V1-VIPs but inhibited V1-SSTs, mirroring the dynamics present during the oddball paradigm. Chemogenetic inhibition of VIP interneurons disrupted ACa-V1 synchrony and deviance detection responses in V1. These results outline spatiotemporal and interneuron-specific mechanisms of top-down modulation that support visual context processing.
LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility
Authors: Hwang Jae Yeon , Chai Pengxin , Nawaz Shoaib , Choi Jungmin , Lopez-Giraldez Francesc , Hussain Shabir , Bilguvar Kaya , Mane Shrikant , Lifton Richard P. , Ahmad Wasim , Zhang Kai , Chung Jean-Ju 
Published: February 2023

AbstractRadial spokes (RS) are T-shaped multiprotein complexes on the axonemal microtubules. Repeated RS1, RS2, and RS3 couple the central pair to modulate ciliary and flagellar motility. Despite the cell type specificity of RS3 substructures, their molecular components remain largely unknown. Here, we report that a leucine-rich repeat-containing protein, LRRC23, is an RS3 head component essential for its head assembly and flagellar motility in mammalian spermatozoa. From infertile male patients with defective sperm motility, we identified a splice site variant ofLRRC23. A mutant mouse model mimicking this variant produces a truncated LRRC23 at the C-terminus that fails to localize to the sperm tail, causing male infertility due to defective sperm motility. LRRC23 was previously proposed to be an ortholog of the RS stalk protein RSP15. However, we found that purified recombinant LRRC23 interacts with an RS head protein RSPH9, which is abolished by the C-terminal truncation. Evolutionary and structural comparison also shows that LRRC34, not LRRC23, is the RSP15 ortholog. Cryo-electron tomography clearly revealed that the absence of the RS3 head and the sperm-specific RS2-RS3 bridge structure in LRRC23 mutant spermatozoa. Our study provides new insights into the structure and function of RS3 in mammalian spermatozoa and the molecular pathogenicity of LRRC23 underlying reduced sperm motility in infertile human males.
A Bayesian network for selecting improvement management tools to increase customer satisfaction in the construction industry: case study of Mexico
Authors: Delgado-Hernández David Joaquín , Palacios-Navarro Ulises Jairo 
Published: February 2023

PurposeThe use of improvement tools in the construction sector has shown to be an important determinant of quality. Companies endeavoring to enhance their daily practices require assistance, evidence, standards, frameworks and quantitative models from existing experts to help them set out for the road. This paper is aimed to assist construction managers in the selection of tools to increase customer satisfaction.Design/methodology/approachThis piece of research is based on the results of a previous empirical study on the use, within a sample of Mexican firms, of a set of more than 30 tools. It then proposes a Bayesian network (BN) to select them. By analyzing the variables under study, it is possible to establish their interaction and dependencies. The resultant BN comprises 24 nodes, and it is useful for choosing some tools that help to increase customer satisfaction.FindingsCustomers and their needs now have become more complicated and harder to meet than in the past. Then, the use of improvement tools that put quality at the heart of the management strategies is crucial for achieving customer satisfaction. In order to reduce prices, keep product quality and meet delivery times, these tools should be used on a daily basis. Along this line of thought, the overall results from the hypothetical scenarios explored in this were positive, reflecting the relevance of the proposed model. In particular, the use of tools for gathering customer needs, the utilization of technology and the implementation of a quality department are relevant for increasing customer satisfaction in the sector.Research limitations/implicationsThe sample size could be further expanded. The customer satisfaction dimensions could be enhanced.Practical implicationsWhile the sample in which the investigation is based could be expanded along with the number of variables and their states, the BN can help practitioners in the global construction industry to improve their quality practices, to foster loyalty and to grow revenues.Originality/valueMost of the research reported in the area of continuous improvement in construction focuses on qualitative considerations, and it is still scarce in terms of developing mathematical models for selecting existing tools and, ultimately, satisfying customer’s requirements. This investigation is aimed to bridge this gap in the literature.
Walking the talk towards sustainable consumption: interventions to promote the uptake of reprocessed construction materials
Authors: Tennakoon Gihan Anuradha , Rameezdeen Raufdeen , Chileshe Nicholas 
Published: February 2023

PurposeThe uptake of reprocessed construction materials (RCMs) derived from demolition waste (DW) is limited, which questions the long-term sustainability of DW reverse logistics (RL). To address this gap, the current study focused on identifying informational and structural interventions to promote the uptake of RCMs among Australian construction professionals (CPs).Design/methodology/approachFollowing a qualitative research approach with thirty-one semi-structured interviews, the study explored potential interventions that can drive broader RCM usage. The study's strength lies in the in-depth qualitative insights gathered through extensive interviews with CPs experienced in using RCMs.FindingsSixteen informational and structural interventions to promote the uptake of RCMs were identified and mapped against the industry levels at which they should be implemented. RCM suppliers should focus on improving material quality, supply and marketing while minimising material costs. Governments should encourage using RCMs through incentivisation, supportive legislation and approval processes. The significance of awareness building and research was also recognised, which requires the collective efforts of suppliers, governmental and non-governmental bodies and educational institutes.Originality/valueDespite the talk around sustainable consumption, the actual walk towards this is limited from a construction perspective, as seen through the low uptake of RCMs. This study attempts to bridge this mismatch by outlining informational and structural interventions that would drive CPs to walk the talk and use RCMs for construction applications. While most studies on DW RL have focused on improving waste recovery processes, this study takes a less-trodden path and explores the potential for developing markets for RCMs.
Visiting museums via augmented reality: an experience fast-tracking the digital transformation of the tourism industry
Authors: Khalil Sabine , Kallmuenzer Andreas , Kraus Sascha 
Published: February 2023

PurposeAugmented reality (AR) is an emergent technology that has been impacting and beneficial to various industries. This is especially the case in the tourism industry since the COVID-19 crisis. To enable and enhance the museum experience, AR technology can be used as a tool to manage visitors' experiences and adapt to the digital transformation of industries. This research work aims to explore the acceptance of museum visitors for the adoption of this technology. For this purpose, the technology acceptance model (TAM) is used as the research lens.Design/methodology/approachThe authors collected 316 responses from a survey handed out to prior visitors of immersive exhibitions shown via AR at the Atelier des Lumières in Paris and analyzed them through a structural equation model approach.FindingsThe study’s findings explain the behavior of visitors when attending immersive exhibitions according to the TAM and highlight two new constructs that need to be considered when using the TAM with AR technology: user satisfaction and social mimetism.Originality/valueThe study’s findings support that implementing AR technology in the museum industry provides great opportunities for the tourism industry to recover from the economic crisis that followed from the COVID-19 health crisis. The authors identified new thriving concepts in the 21st century with the rise of social media, such as social mimetism, that propels visitors to have a positive attitude and intention to attend immersive exhibitions.
Management innovation and its relation to innovation outcomes and firm performance: a systematic literature review and future research agenda
Authors: Henao-García Edwin Alexander , Cardona Montoya Raúl Armando 
Published: February 2023

PurposeThe main purpose of this review is to enhance the understanding of intellectual structure and outlook of management innovation research as an interesting and growing research field.Design/methodology/approachThis systematic literature review examines the question, what is the relationship of management innovation with the performance of companies and with other types of innovation? The work also pursues to summarize theories, contexts, characteristics of the papers and methodologies with the purpose of facilitating further development and opportunities and priorities for future research.FindingsThe results suggest that management innovation is an interesting and growing research field; in its relation to different types of innovation and performance, it is a field explored with theoretical approaches, contexts and methodologies that begin to form a consolidated body of knowledge. However, through a critical analysis, this review highlights the gaps in the literature and provides suggestions for future studies to further explore the field. This revision contributes to the literature on management innovation summarizing the findings and contributions of research published in the field and its relationships with innovation and performance. It then identifies three comprehensive research streams, namely, future research on conceptualization, definitions and measurements; research on the level of analysis; and future research on management innovation drivers, antecedents and use as mediator/moderator variables.Originality/valueManagement innovation is an emerging research field that is characterized as a branch of research long ignored by more orthodox lines dedicated to technological innovation and topics in product and service development research.
Barriers to service transition in an innovation ecosystem: a qualitative study
Authors: Carneiro Dênio , Franco Mário , Rodrigues Margarida 
Published: February 2023

PurposeThis study arises from the need to understand the servitization or service transition process in non-manufacturing firms and sets out from a taxonomy proposed in the literature (Lütjen et al., 2017). This study aims to identify the barriers to service transition in small and medium-sized enterprises (SME) participating in an innovation ecosystem and how these small firms can benefit from this strategy to develop in this scale.Design/methodology/approachA qualitative study was carried out based on multiple case studies, data being collected through semi-structured interviews with service business-people belonging to a science and technology park situated in an inland region of Portugal.FindingsFrom content analysis, the results obtained indicated a lack of specialized personnel as the main barrier and as a strategy to overcome this situation these companies turned to business cooperation. This means that good management of this cooperation increases the quality of the services provided, as inter-organizational networks, through participation in ecosystems, can secure a wider set of resources and capacities.Practical implicationsThis study shows that firms try out different service offers simultaneously and that innovation capacity increases constantly during service transition. Secondly, the study emphasizes the importance of innovation ecosystems, entrepreneurship, servitization and cooperation networks in promoting resilient and small ventures. Thus, this study can help owner-managers, SMEs and political decision-makers to make better informed decisions, which can be particularly relevant in scenarios of uncertainty and crisis.Originality/valueThis study draws conclusions in a little explored empirical area in the literature, challenging the widespread understanding that service transition is used only in manufacturing firms. This study provides clearer conceptual understanding of service transition from a network and relational perspective which, despite the perspective's relevance, still lacks research in the context of servitization.
Environmental sustainability performance and shareholder value: an international fuzzy-set qualitative comparative analysis
Authors: Jouber Habib 
Published: February 2023

PurposeConsidering corporate governance (CG hereinafter) practices' variety across Anglo-American and European countries, this study relies on contingency and complexity theories to investigate the effect of environmental sustainability performance (ESP hereinafter) on shareholder value under various configurations of board of directors (BoD hereinafter), firm and country characteristics.Design/methodology/approachThe author used the Thomson Reuters Environment Pillar Score (ASSET4) and the Total Shareholder Return to assess ESP and shareholder value respectively. The author applied a fuzzy-set qualitative comparative analysis (fsQCA hereinafter) to an unbalanced panel of 2,284 observations from 486 European and Anglo-American non-financial listed firms over the period 2016–2020.FindingsThe author found a positive association between ESP and shareholder value and he displayed notable differences between Anglo-American and European economies regarding causal predictors of this positive association. Within European firms operating under civil law code where investor protection is low and family ownership is widespread, ESP creates shareholder value under configurations of causal predictors that significantly differ from those of their Anglo-American peers. The author's findings are robust to different identification strategies.Practical implicationsThis study assists researchers, practitioners, shareholders and policymakers the significant roles that BoD diversity, organisational and institutional traits are jointly playing as determinants of the ESP-shareholder value relationship.Originality/valueThe author's study offers a more encompassing, complete and theoretically richer picture of the key drivers and outcomes of ESP.