bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Multiple Recesses on Limb Movement Patterns in Children: An Exploratory Study
Authors: Webb G. Kate , Rhea Deborah J. 
Published: September 2023

Background: Inactivity levels among elementary-aged children are climbing at alarming rates, as only 24% participate in the recommended 60 minutes of daily physical activity. Limb movements during children’s active time are essential for heart, bone, and muscle health, setting the stage for an overall active and healthy life. School recess, defined as child-directed, outdoor play, is optimal for children to accumulate many types and repetitions of limb movements. Therefore, the purpose of this study was to use the Movement Pattern Observation Tool (MPOT) to determine the impact of varying amounts of daily recess on elementary-aged children’s limb movement patterns. It was hypothesized that children who participate in 60 minutes of daily recess would accumulate significantly more limb movements and specifically, contralateral movements as they advance in grades.
Methods: This cross-sectional, observational study used the MPOT to observe grades K-2 children from two schools offering one twenty-minute recess daily and two schools offering four 15-minute recesses daily. The researchers observed 3,023 children’s limb movements during recess across the schools. There were 36 total observation scans completed for the four schools observed.
Results: Children who received 60 minutes of recess maintained significantly higher activity levels and contralateral movements as they advanced by grade. Additionally, on average 96% of all children utilized unilateral, bilateral, or contralateral limb movements when observed.
Conclusion: When given the opportunity, most children will utilize recess in a way that is beneficial for off-setting inactivity trends and is instrumental for a healthy mind-body connection as they age.
Electronic Health Record Usage in an Academic Orthopaedic Sports Medicine Practice
Authors: Como Christopher J. , Flanagan Meredith , Cong Guang-Ting , Como Matthew , Hughes Jonathan D. , Rabuck Stephen J. , Lesniak Bryson P. , Lin Albert 
Published: September 2023

Background While the relationship between electronic health record usage and physician burnout has been investigated in other specialties, no reports exist for orthopaedic surgery. The purpose of this study was to determine the amount of time spent on the electronic health record compared to actual patient interaction in four busy orthopaedic outpatient clinics. Hypothesis We hypothesized that surgeons would spend as much time on the electronic health record as they do interacting with patients on a typical clinic day. Methods Four busy academic orthopaedic surgeons (Surgeon 1, 2, 3, and 4) at a tertiary academic institution were each followed on clinic days to determine their total time spent on Epic Hyperspace electronic health record as compared to face-to-face interactions with patients. A research assistant recorded the amount of time each surgeon spent dictating notes, writing orders, or replying to clinical inbox messages (electronic health record time) and how much time was spent on loading screens or electronic health record buffering (loading time) during which no actions could be completed. Results Surgeon 1 spent an average of 63% of their clinic days using the electronic health record. Surgeon 2 spent 50% of their time on the computer. Surgeon 3 spent 35% of his days on the computer. Surgeon 4 spent 46% of his days on the computer. Conclusion Approximately half of each surgeon’s clinic time was spent using the electronic health record. Given the known influence of electronic health record usage on orthopaedic surgeon burnout, this is an issue that needs to be addressed. The solution likely involves a multifactorial approach, including changes to electronic health records, widespread use of scribes or advanced care teams, work hour limitations, and mindfulness training for residents and faculty. Information technology quality improvements can be made to EHRs that include reducing or eliminating unnecessary information displayed on screen, providing more abundant and accessible EHR training and on-site technical support, and a more streamlined software interface that eliminates unnecessary typing and clicks to improve charting flow and efficiency. Level of Evidence Level IV Descriptive Study
بررسی مشخصات مریضان سوختگی برقی در بخش جراحی پلاستیک و سوختگی شفاخانه حوزوی هرات (1397-1400 ه. ش)
Authors: سعادت عبدالسمیع , رحیمی علی , شایان نثاراحمد , شایان شراره 
Published: September 2023

پیشینه و هدف: سوختگی برقی در مقایسه با سایر انواع جراحات ناشی از سوختگی شیوع کمتری دارد، اما این نوع آسیب به دلیل عوارض و مرگ‌ومیر بالا، یکی از مخرب‌ترین آسیب‌ها محسوب می‌شود. درک الگوی اپیدمیولوژیک سوختگی‌های برقی به تعیین عوامل کمک‌کننده منجر به این نوع آسیب کمک می‌کند. مطالعات اپیدمیولوژیک در مورد سوختگی برقی در افغانستان بسیار نادر است. هدف این مطالعه بررسی اپیدمیولوژیک موارد سوختگی برقی در مرکز جراحی پلاستیک شهر هرات می‌باشد.
روش تحقیق: در این مطالعه توصیفی که از اول حمل 1397 تا آخر جدی 1400 در شفاخانه حوزوی هرات صورت گرفته است، اطلاعات فردی اجتماعی، علت، درصد سوختگی و سایر اقدامات مربوط به آسیب سوختگی برقی 75 مریض تحت تداوی جمع‌آوری و مورد تحلیل قرارگرفته است.
یافته‌ها: یافته‌های تحقیق نشان می‌دهند که بیش‌ترین وقوعات سوختگی در گروه سنی 20 تا 30 سال (32.0٪) و مرد‌ان (73.3٪) اتفاق افتاده است. حدود یک‌سوم سوختگی‌ها (31.0٪) در دست راست اتفاق افتاده، در 38.7٪ موارد سوختگی‌ها کمتر از 5٪ بوده است و 34.7٪ سوختگی‌ها در فصل زمستان رخ‌داده است. مهم‌ترین روش عملیاتی فاشیوتومی (31.2٪) بوده است. یک مورد آمپوتیش و یک مورد مرگ‌ومیر نیز در طی بررسی مشاهده شد.
نتیجه‌گیری: نتایج این مطالعه تأکید بر شیوع سوختگی در رده‌های سنی و جنسی خاص دارد. قربانیان سوختگی برقی را بیشتر مردان تشکیل می‌دهند. آموزش مردم در مورد خطرات ناشی از استفاده نادرست از وسایل و ابزار برقی مفید بوده می‌تواند. انجام مطالعات وسیع‌تر در سطح کشور برای تعیین دقیق‌تر وقوعات و اختلاطات سوختگی بسیار ضروری می‌باشد.
The Effect of Know What Learn (KWL) Strategy to Improve Students’ Reading Comprehension in Descriptive Text at Tenth Grade SMAN Negeri 8 Tebo
Authors: Auladiyah Robiatul , Nurni Khairita Martiya , Widia Nanda Dodi 
Published: September 2023

Reading comprehension is a reading activity to absorb information from the reading material and understand or know the implied meaning and meaning of the reading so that it can be conveyed properly to the reader. The research aims to find out the effect of KWL strategy to improve students’ reading comprehension. This research used quantitative. Reading test was used as the instrument to taken the data. This research used two classes which is experimental class and control class. There were 14 students who registered in control class and 14 students in experiment class. The result showed the students’ mean score in the post-test of the experimental class and control class, the mean score in the post-test of the experimental class was 68.29 and the mean score in the post-test of the control class was 47.93. T-test was used to answer the research question and conducted in both the experimental class and control class by used IBM SPSS 20. The result of T-test showed that the significance paired samples T-test is 0.000<0.05, which mean H0 is rejected and Ha is accepted. Thus, it is concluded that there is a significant effect of using KWL strategy to improve students’ reading comprehension.
Ranitidine Use and Incident Cancer in a Multinational Cohort
Authors: You Seng Chan , Seo Seung In , Falconer Thomas , Yanover Chen , Duarte-Salles Talita , Seager Sarah , Posada Jose D. , Shah Nigam H. , Nguyen Phung-Anh , Kim Yeesuk , Hsu Jason C. , Van Zandt Mui , Hsu Min-Huei , Lee Hang Lak , Ko Heejoo , Shin Woon Geon , Pratt Nicole , Park Rae Woong , Reich Christin G. , Suchard Marc A. , Hripcsak George , Park Chan Hyuk , Prieto-Alhambra Daniel 
Published: September 2023

ImportanceRanitidine, the most widely used histamine-2 receptor antagonist (H2RA), was withdrawn because of N-nitrosodimethylamine impurity in 2020. Given the worldwide exposure to this drug, the potential risk of cancer development associated with the intake of known carcinogens is an important epidemiological concern.ObjectiveTo examine the comparative risk of cancer associated with the use of ranitidine vs other H2RAs.Design, Setting, and ParticipantsThis new-user active comparator international network cohort study was conducted using 3 health claims and 9 electronic health record databases from the US, the United Kingdom, Germany, Spain, France, South Korea, and Taiwan. Large-scale propensity score (PS) matching was used to minimize confounding of the observed covariates with negative control outcomes. Empirical calibration was performed to account for unobserved confounding. All databases were mapped to a common data model. Database-specific estimates were combined using random-effects meta-analysis. Participants included individuals aged at least 20 years with no history of cancer who used H2RAs for more than 30 days from January 1986 to December 2020, with a 1-year washout period. Data were analyzed from April to September 2021.ExposureThe main exposure was use of ranitidine vs other H2RAs (famotidine, lafutidine, nizatidine, and roxatidine).Main Outcomes and MeasuresThe primary outcome was incidence of any cancer, except nonmelanoma skin cancer. Secondary outcomes included all cancer except thyroid cancer, 16 cancer subtypes, and all-cause mortality.ResultsAmong 1 183 999 individuals in 11 databases, 909 168 individuals (mean age, 56.1 years; 507 316 [55.8%] women) were identified as new users of ranitidine, and 274 831 individuals (mean age, 58.0 years; 145 935 [53.1%] women) were identified as new users of other H2RAs. Crude incidence rates of cancer were 14.30 events per 1000 person-years (PYs) in ranitidine users and 15.03 events per 1000 PYs among other H2RA users. After PS matching, cancer risk was similar in ranitidine compared with other H2RA users (incidence, 15.92 events per 1000 PYs vs 15.65 events per 1000 PYs; calibrated meta-analytic hazard ratio, 1.04; 95% CI, 0.97-1.12). No significant associations were found between ranitidine use and any secondary outcomes after calibration.Conclusions and RelevanceIn this cohort study, ranitidine use was not associated with an increased risk of cancer compared with the use of other H2RAs. Further research is needed on the long-term association of ranitidine with cancer development.
Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences
Authors: Li Jingqi , Cai Xinda , Jiang Peng , Wang Huayuan , Zhang Shiwei , Sun Tiedong , Chen Chunxia , Fan Kelong 
Published: September 2023

AbstractNanozymes, next‐generation enzyme‐mimicking nanomaterials, have entered an era of rational design; among them, Co‐based nanozymes have emerged as captivating players over times. Co‐based nanozymes have been developed and have garnered significant attention over the past five years. Their extraordinary properties, including regulatable enzymatic activity, stability, and multifunctionality stemming from magnetic properties, photothermal conversion effects, cavitation effects, and relaxation efficiency, have made Co‐based nanozymes a rising star. This review presents the first comprehensive profiling of the Co‐based nanozymes in the chemistry, biology, and environmental sciences. The review begins by scrutinizing the various synthetic methods employed for Co‐based nanozyme fabrication, such as template and sol‐gel methods, highlighting their distinctive merits from a chemical standpoint. Furthermore, a detailed exploration of their wide‐ranging applications in biosensing and biomedical therapeutics, as well as their contributions to environmental monitoring and remediation is provided. Notably, drawing inspiration from state‐of‐the‐art techniques such as omics, a comprehensive analysis of Co‐based nanozymes is undertaken, employing analogous statistical methodologies to provide valuable guidance. To conclude, a comprehensive outlook on the challenges and prospects for Co‐based nanozymes is presented, spanning from microscopic physicochemical mechanisms to macroscopic clinical translational applications.
Reliability of field‐ and laboratory‐based assessments of health‐related fitness in preschool‐aged children
Authors: King‐Dowling Sara , Fortnum Kathryn , Chirico Daniele , Le Tuyen , Kwan Matthew Y. W. , Timmons Brian W. , Cairney John 
Published: September 2023

AbstractObjectivesReliable measurements of health‐related fitness—cardiorespiratory endurance, muscular endurance, muscular strength, body composition, and flexibility—are imperative for understanding and tracking health‐related fitness from the preschool age. This study aimed to examine the test–retest reliability of field‐based (i.e., sit and reach [standard and back‐saver], standing long jump, grip strength); and laboratory‐based (i.e., Bruce Protocol Treadmill Test, Wingate Anaerobic Test) assessments of health‐related fitness in preschool aged children (4–5 years).MethodsForty‐two typically developing children participated in both assessment time points separated by 2–3 weeks. All fitness assessments were administered individually and repeated in the same order by the same assessor. Heteroscedasticity was examined for each parameter. Intraclass correlation coefficients were calculated to assess test–retest reliability.ResultsAll parameters were homoscedastic. Test–retest reliability for the field‐based tests and Bruce Protocol Treadmill Test parameters were moderate to good. Test–retest reliability for the Wingate Test parameters were good to excellent for maximum pedal rate, peak power, and peak power/kg; mean power and fatigue measured at 10 and 30 s demonstrated moderate to excellent test–retest reliability.ConclusionThe standard sit and reach, grip strength, and short‐term muscle power from the Wingate test are reliable assessments of health‐related fitness in preschool‐aged children.
Covariation between the shape and mineralized tissues of the rib cross section in Homo sapiens, Pan troglodytes and Sts 14
Authors: López‐Rey José M. , Cambra‐Moo Óscar , González Martín Armando , Candelas González Nieves , Sánchez‐Andrés Ángeles , Tawane Mirriam , Cazenave Marine , Williams Scott A. , Bastir Markus , García‐Martínez Daniel 
Published: September 2023

AbstractObjectivesStudying rib torsion is crucial for understanding the evolution of the hominid ribcage. Interestingly, there are variables of the rib cross section that could be associated with rib torsion and, consequently, with the morphology of the thorax. The aim of this research is to conduct a comparative study of the shape and mineralized tissues of the rib cross section in different hominids to test for significant differences and, if possible, associate them to different thoracic morphotypes.Materials and MethodsThe sample consists of the rib cross sections at the midshaft taken from 10 Homo sapiens and 10 Pan troglodytes adult individuals, as well as from A. africanus Sts 14. The shape of these rib cross sections was quantified using geometric morphometrics, while the mineralized tissues were evaluated using the compartmentalization index. Subsequently, covariation between both parameters was tested by a Spearman's ρ test, a permutation test and a linear regression.ResultsGenerally, P. troglodytes individuals exhibit rib cross sections that are rounder and more mineralized compared to those of H. sapiens. However, the covariation between both parameters was only observed in typical ribs (levels 3–10). Although covariation was not found in the rib cross sections of Sts 14, their parameters are closer to P. troglodytes.DiscussionOn the one hand, the differences observed in the rib cross sections between H. sapiens and P. troglodytes might be related to different degrees of rib torsion and, consequently, to different thoracic 3D configurations. These findings can be functionally explained by considering their distinct modes of breathing and locomotion. On the other hand, although the rib cross sections belonging to Sts 14 are more similar to those of P. troglodytes, previous publications determined that their overall morphology is closer to modern humans. This discrepancy could reflect a diversity of post‐cranial adaptations in Australopithecus.
A Case of Very Early‐Onset Crohn's Disease Presenting With Intractable Stomatitis and Cheilitis as Its Major Signs
Authors: Saitoh Issei , Kurosawa Mie , Nagai Haruka , Fujii Toru , Aoyagi You , Nakakura‐Ohshima Kuniko , Iwase Yoko , Hayasaki Haruaki , Shirakawa Tetsuo 
Published: September 2023

BackgroundOral inflammatory lesions assist in the diagnosis of certain systemic diseases that primarily affect other organs.MethodsA young girl, 3 years and 3 months old, presented with aphthous stomatitis, upper lip cheilitis, and swelling and bleeding of the upper gingiva. She had a medical history of repeated fever, skin tag of the anus, and constipation. Thus, it was suspected that her disease is a systemic disease with digestive symptoms. From clinical manifestation and endoscopy findings containing aphthoid ulcers in the bowel, she was diagnosed with very early‐onset Crohn's disease (CD). Immediately, mesalazine was started.ResultsAfter 1 month, the oral symptoms were dramatically improved, and her general condition stabilized.ConclusionsOral symptoms often precede the appearance of gastrointestinal lesions in young CD patients, and oral conditions worsen if the disease remains untreated. Thus, assessment of patients with intractable stomatitis from the viewpoint of CD may aid in rapid diagnosis and better prognosis.
17‐Year Follow‐Up of Ridge Augmentation in a Patient With Linear Scleroderma: A Novel Case Report
Authors: Goldberg David A. , Pinn Marvin , Goldberg Adam S. 
Published: September 2023

IntroductionScleroderma is a chronic autoimmune disease associated with connective tissue changes and fibrosis, which often includes oral manifestations. Involvement of the oral mucosa results in gingival recession, loss of alveolar housing, root resorption, gross mobility, and other deleterious side effects. Therefore, patients may require extensive restorative care, but pathology can often prevent optimal delivery.Case PresentationThe following case presents a patient with localized scleroderma requiring a ridge augmentation for the placement of a fixed partial denture. Following the disease diagnosis and treatment planning, the patient received local subcutaneous injections of 25 mg‐methotrexate to halt disease progression. Given the success of the prophylaxis, the patient underwent three extractions followed by two surgical augmentation procedures, including the placement of xenographic bovine matrix and an overlying connective tissue graft. Healing occurred within normal limits, allowing the successful delivery of a permanent prosthesis.ConclusionsThis case presentation is the first to our knowledge to document successful soft tissue ridge augmentation in a patient with localized scleroderma in order to place a fixed bridge; thereby, documenting the feasibility of esthetically restoring patients presenting with said systemic disease. The case uniquely illustrates identification of a rare connective tissue disease that saw successful treatment outcomes due to proper diagnosis, disease management, interprofessional collaboration, and advanced treatment planning.
Anomalous right coronary artery originating from the opposite sinus of Valsalva: Fractional flow reserve and intravascular ultrasound‐guided management
Authors: Singh Arushi , Donnino Robert , Small Adam , Bangalore Sripal 
Published: September 2023

AbstractThere remains significant controversy in the risk stratification and management of patients with anomalous right coronary artery originating from the opposite sinus (R‐ACAOS). We present the case of a patient with an inferior ST‐elevation myocardial infarction, found to have R‐ACAOS and severe atherosclerotic right coronary artery disease, treated with fractional flow reserve and intravascular ultrasound‐guided percutaneous coronary intervention.
Enhancement of Zinc(II) Phthalocyanine Photophysical Properties in Water by Sulfonatocalix[4]arene‐Based Micelles
Authors: Ezquerra Riega Sergio D. , Cammarata Agostina , Marino Julieta , Roguin Leonor P. , Glisoni Romina J. , Lantaño Beatriz 
Published: September 2023

AbstractZinc phthalocyanines have demonstrated a wide range of applications as photosensitisers, particularly in organic synthesis, photocatalysis and photodynamic therapy. Although the introduction of ionic groups on the macrocycle periphery increases their water solubility, aggregation phenomena remain as a significant drawback for their application. In this study, amphiphilic sulfonatocalix[4]arene‐based micelles were used to promote the monomerization of a cationic phthalocyanine through host–guest interactions. A comprehensive spectroscopic characterization was conducted, varying the concentration of sulfonatocalix[4]arene, and binding parameters were calculated to determine the optimal conditions for complete monomerization of the photosensitizer in water. Under these conditions, the combination of sulfonatocalix[4]arene and the photosensitizer activated its photophysical activity in aqueous media, showing significant singlet oxygen photoproduction, photocatalytic capability and photostability.
Synthesis of 4′‐Thiomodified c‐di‐AMP Analogs
Authors: Saito‐Tarashima Noriko , Kagotani Yuma , Inoue Syuya , Kinoshita Mao , Minakawa Noriaki 
Published: September 2023

AbstractCyclic diadenosine monophosphate (c‐di‐AMP) is a bacterial cyclic dinucleotide (CDN) comprising two adenosine monophosphates covalently linked by two 3′,5′‐phosphodiester bonds. c‐di‐AMP works as a second messenger, regulating many biological processes in bacteria such as cell wall homeostasis, DNA integrity, and sporulation via specific protein and/or RNA receptors. Moreover, c‐di‐AMP can function as an immunomodulatory agent in eukaryote cells via the stimulator of interferon genes (STING) signaling pathway.This protocol describes the chemical synthesis of two c‐di‐AMP analogs with a sulfur atom at the 4′‐position of the furanose ring instead of an oxygen atom: c‐di‐4′‐thioAMP (1) and cAMP‐4′‐thioAMP (2). Analogs 1 and 2 have resistance to phosphodiesterase‐mediated degradation and are therefore useful for understanding the diverse biological phenomena regulated by c‐di‐AMP. In this protocol, two 4′‐thioadenosine monomers are initially prepared via a Pummerer‐like reaction assisted by hypervalent iodine. The CDN skeleton is then constructed through two key reactions based on phosphoramidite chemistry: dimerization of two appropriately protected nucleoside monomers to produce a linear dinucleotide, followed by macrocyclization of the resulting linear dinucleotide to form the CDN skeleton. © 2023 Wiley Periodicals LLC.Basic Protocol 1: Preparation of 4′‐thioadenosine monomers 13 and 14Basic Protocol 2: Preparation of c‐di‐4′‐thioAMP (1) and cAMP‐4′‐thioAMP (2)