bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of high-crystalline and non-metal modified g-C3N4 for improving ultrasound-accelerated white-LED-light-driven photocatalytic performances
Authors: Tarighati Sareshkeh Abdolreza , Seyed Dorraji Mir Saeed , Karami Zhaleh , Shahmoradi Saeedeh , Fekri Elnaz , Daneshvar Hoda , Rasoulifard Mohammad Hossein , Karimov Denis N. 
Published: September 2023

AbstractAs a non-metallic organic semiconductor, graphitic carbon nitride (g-C3N4) has received much attention due to its unique physicochemical properties. However, the photocatalytic activity of this semiconductor faces challenges due to factors such as low electronic conductivity and limited active sites provided on its surface. The morphology and structure of g-C3N4, including macro/micro morphology, crystal structure and electronic structure can affect its catalytic activity. Non-metallic heteroatom doping is considered as an effective method to tune the optical, electronic and other physicochemical properties of g-C3N4. Here, we synthesized non-metal-doped highly crystalline g-C3N4 by one-pot calcination method, which enhanced the photocatalytic activity of g-C3N4 such as mesoporous nature, reduced band gap, wide-range photousability, improved charge carrier recombination, and the electrical conductivity was improved. Hence, the use of low-power white-LED-light illumination (λ ≥ 420 nm) and ultrasound (US) irradiation synergistically engendered the Methylene Blue (MB) mineralization efficiency elevated to 100% within 120 min by following the pseudo-first-order mechanism under the following condition (i.e., pH 11, 0.75 g L−1 of O-doped g-C3N4 and S-doped g-C3N4, 20 mg L−1 MB, 0.25 ml s−1 O2, and spontaneous raising temperature). In addition, the rapid removal of MB by sonophotocatalysis was 4 times higher than that of primary photocatalysis. And radical scavenging experiments showed that the maximum distribution of active species corresponds to superoxide radical $${\mathrm{O}}_{2}^{\cdot-}$$

O

2

·
-

. More importantly, the sonophotocatalytic degradation ability of O-doped g-C3N4 and S-doped g-C3N4 was remarkably sustained even after the sixth consecutive run.
Ameliorative effects of camel milk and silymarin upon aflatoxin B1 induced hepatic injury in rats
Authors: Hassaneen Nahla H. , Hemeda Shabaan A. , El Nahas Abeer F. , Fadl Sabreen E. , El-diasty Eman M. 
Published: September 2023

AbstractAflatoxin B1 (AFB1) poses a major risk to both human and animal health because it contaminates food, feed, and grains. These dangerous effects can be mitigated using natural components. The purpose of this study was to examine the ameliorative effects of camel milk and silymarin supplementation upon aflatoxin B1 induced hepatic injury in rats. This improvement was assessed by measuring leukocytic and deferential counts, serum biochemical parameters, and gene expression of Tumor Necrosis Factor (TNF-α), antioxidant gene (NAD(P)H quinone oxidoreductase 1 (NQO1)), and base excision repair genes (APE1 and OGG1) in the liver tissue, in addition to liver histopathology. Sixty mature males Wister white rats were used to perform the present study; the rats were distributed in six groups (ten rats/group). The control group (without any treatment) received saline by gavage. The camel milk group received 1 ml of camel milk/kg body weight. The silymarin group received 1 ml of silymarin suspension solution at a dose of 20 mg of silymarin/kg of b.wt. The aflatoxin group received an aflatoxin-contaminated diet at a dose of 1.4 mg of aflatoxin /kg of diet and received saline. The camel milk + aflatoxin group received the same previous oral doses of camel milk and an aflatoxin-contaminated diet at the same time. The silymarin + aflatoxin group received the same previous doses of silymarin orally and an aflatoxin-contaminated diet at the same time. The obtained data indicated the deleterious effect of aflatoxin B1 on the leukocytic count, activity of AST and ALT, serum proteins, ferritin, alpha-fetoprotein, carcinoembryonic antigen, liver pathology, and the expression of the studied genes. However, these deleterious effects were mitigated by camel milk and silymarin supplementation. Thus, we could conclude that the ingestion of camel milk and silymarin mitigated the negative effects of AFB1 on the hematology, activity of AST and ALT, serum proteins, ferritin, alpha-fetoprotein, carcinoembryonic antigen, liver pathology, and gene expression in the rat model.
Red blood cell distribution width for the prediction of outcomes after cardiac arrest
Authors: Urben Tabita , Amacher Simon A. , Becker Christoph , Gross Sebastian , Arpagaus Armon , Tisljar Kai , Sutter Raoul , Pargger Hans , Marsch Stephan , Hunziker Sabina 
Published: September 2023

Abstract The red blood cell distribution width (RDW) is a routinely available blood marker that measures the variation of the size/volume of red blood cells. The aim of our study was to investigate the prognostic value of RDW in cardiac arrest patients and to assess whether RDW improves the prognostic value of three cardiac arrest-specific risk scores. Consecutive adult cardiac arrest patients admitted to the ICU of a Swiss university hospital were included. The primary outcome was poor neurological outcome at hospital discharge assessed by Cerebral Performance Category. Of 702 patients admitted to the ICU after cardiac arrest, 400 patients (57.0%) survived, of which 323 (80.8%) had a good neurological outcome. Higher mean RDW values showed an independent association with poor neurological outcomes at hospital discharge (adjusted OR 1.27, 95% CI 1.14 to 1.41; p < 0.001). Adding the maximum RDW value to the OHCA- CAHP- and PROLOGUE cardiac arrest scores improved prognostic performance. Within this cohort of cardiac arrest patients, RDW was an independent outcome predictor and slightly improved three cardiac arrest-specific risk scores. RDW may therefore support clinical decision-making.
Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart
Authors: Del Gaudio Francesca , Liu Dongli , Andaloussi Mäe Maarja , Braune Eike-Benjamin , Hansson Emil M. , Wang Qing-Dong , Betsholtz Christer , Lendahl Urban 
Published: September 2023

AbstractThe heart depends on a functional vasculature for oxygenation and transport of nutrients, and it is of interest to learn how primary impairment of the vasculature can indirectly affect cardiac function and heart morphology. Notch3-deficiency causes vascular smooth muscle cell (VSMC) loss in the vasculature but the consequences for the heart remain largely elusive. Here, we demonstrate that Notch3-/- mice have enlarged hearts with left ventricular hypertrophy and mild fibrosis. Cardiomyocytes were hypertrophic but not hyperproliferative, and the expression of several cardiomyocyte markers, including Tnt2, Myh6, Myh7 and Actn2, was altered. Furthermore, expression of genes regulating the metabolic status of the heart was affected: both Pdk4 and Cd36 were downregulated, indicating a metabolic switch from fatty acid oxidation to glucose consumption. Notch3-/- mice furthermore showed lower liver lipid content. Notch3 was expressed in heart VSMC and pericytes but not in cardiomyocytes, suggesting that a perturbation of Notch signalling in VSMC and pericytes indirectly impairs the cardiomyocytes. In keeping with this, Pdgfbret/ret mice, characterized by reduced numbers of VSMC and pericytes, showed left ventricular and cardiomyocyte hypertrophy. In conclusion, we demonstrate that reduced Notch3 or PDGFB signalling in vascular mural cells leads to cardiomyocyte dysfunction.
Capture and transport of rod-shaped cargo via programmable active particles
Authors: Stengele Philipp , Lüders Anton , Nielaba Peter 
Published: September 2023

AbstractWe study the influence of the cargo shape on the capture and transport process of colloidal rods via swarms of active particles using Brownian dynamics simulations. Starting at random initial conditions, active particles that interact via the Lennard-Jones potential and possess a tuneable speed are utilised to capture passive rods inside a hexagonal cage of individually addressable units. By adjusting the velocity of the individual active particles, the rod can then be transported. To guarantee a successful capture process (with a strong localisation), we find that specific geometric and energetic constraints have to be met; i.e., the length of the rod must approximately be in the vicinity of an odd multiple of the lattice constant of the hexagonal cage, and the Lennard-Jones interaction strength must be in the range of $$3.0 \, k_B T$$

3.0

k
B

T

to $$6.0 \, k_B T$$

6.0

k
B

T

. If the cargo aspect ratio gets too large, the subsequent transport of successfully captured rods can fail. For systems where transport is possible, an increase in the cargo aspect ratio decreases the achievable transport velocity. Our work shows that the particle shape must be considered while designing interaction rules to accomplish specific tasks via groups of controllable units.
A FOCUS-PDCA quality improvement model for reducing the distribution defect rate of sterile packages
Authors: Huang Yongdeng , Huang Yan , Yi Liangying , Pan Wei , Chen Yanhua 
Published: September 2023

AbstractThis study aimed to investigate the effect of the application of the FOCUS-PDCA quality improvement model in terms of reducing the distribution defect rate of the sterile packages processed by the CSSD. The FOCUS-PDCA quality improvement model was applied to analyze the causes of the distribution defects of sterile packages, develop improvement measures, and compare the distribution defect rates before and after the application of the FOCUS-PDCA model. Following implementation of the FOCUS-PDCA quality improvement model, the distribution defect rate of sterile packages decreased from 1.74 to 0.37% (P < 0.05). The FOCUS-PDCA quality improvement model can produce a substantial reduction in the distribution defect rate of sterile packages, ensuring the quality of sterile supplies.
An easy adjustment of instrument settings (‘Peak MALDI’) improves identification of organisms by MALDI-ToF mass spectrometry
Authors: Nellessen Christopher M. , Nehl David B. 
Published: September 2023

AbstractMatrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF MS) is a mature technology with ‘auto-execute’ instrument settings and peak processing parameters tailored for rapid bacterial identification. Adoption for other organisms has been problematic, with optimisation efforts focusing on sample preparation. Using the Bruker MALDI Biotyper, we demonstrate ‘Peak MALDI’: easily-applied settings that immediately enhance sensitivity, improve spectrum quality, and increase identification confidence for any target, establishing its potential value for all MALDI-ToF MS systems.
Possible impacts of vegetation cover increment on the relationship between winter snow cover anomalies over the Third Pole and summer precipitation in East Asia
Authors: Yang Kai , Qi Qi , Wang Chenghai 
Published: September 2023

AbstractSnow cover over the Tibetan Plateau (TP)–the Third Pole of the earth has been recognized as a reliable signal of summer floods or droughts in East Asia (EA). The distribution of snow cover can be influenced by vegetation, however, the impacts of changes in cover of non-growing season vegetation–withered grass stem over TP on the climatic effects of snow cover remains poorly understood. Here, we showed that the relationship between TP winter snow cover (TPWSC) and EA summer precipitation (EASP) strengthened starting in the early 1990s but weakened after the early 2000s. The weakening of the TPWSC–EASP relationship was linked to the effects of vegetation cover increment (VCI) on winter and spring snow cover over the TP. A possible mechanism behind this linkage is that VCI leads to a shortened persistence of TPWSC anomalies and weakened surface diabatic heating anomalies in spring. Consequently, the influences of TP thermal forcing on the downstream atmospheric circulation in summer were altered, resulting in a different pattern of EASP anomalies. These findings highlight the importance of snow—vegetation feedback and its potential to alter the effectiveness of snow cover in seasonal climate prediction.
A deep learning-based electrocardiogram risk score for long term cardiovascular death and disease
Authors: Hughes J. Weston , Tooley James , Torres Soto Jessica , Ostropolets Anna , Poterucha Tim , Christensen Matthew Kai , Yuan Neal , Ehlert Ben , Kaur Dhamanpreet , Kang Guson , Rogers Albert , Narayan Sanjiv , Elias Pierre , Ouyang David , Ashley Euan , Zou James , Perez Marco V. 
Published: September 2023

AbstractThe electrocardiogram (ECG) is the most frequently performed cardiovascular diagnostic test, but it is unclear how much information resting ECGs contain about long term cardiovascular risk. Here we report that a deep convolutional neural network can accurately predict the long-term risk of cardiovascular mortality and disease based on a resting ECG alone. Using a large dataset of resting 12-lead ECGs collected at Stanford University Medical Center, we developed SEER, the Stanford Estimator of Electrocardiogram Risk. SEER predicts 5-year cardiovascular mortality with an area under the receiver operator characteristic curve (AUC) of 0.83 in a held-out test set at Stanford, and with AUCs of 0.78 and 0.83 respectively when independently evaluated at Cedars-Sinai Medical Center and Columbia University Irving Medical Center. SEER predicts 5-year atherosclerotic disease (ASCVD) with an AUC of 0.67, similar to the Pooled Cohort Equations for ASCVD Risk, while being only modestly correlated. When used in conjunction with the Pooled Cohort Equations, SEER accurately reclassified 16% of patients from low to moderate risk, uncovering a group with an actual average 9.9% 10-year ASCVD risk who would not have otherwise been indicated for statin therapy. SEER can also predict several other cardiovascular conditions such as heart failure and atrial fibrillation. Using only lead I of the ECG it predicts 5-year cardiovascular mortality with an AUC of 0.80. SEER, used alongside the Pooled Cohort Equations and other risk tools, can substantially improve cardiovascular risk stratification and aid in medical decision making.
Expression of the human usherin c.2299delG mutation leads to early-onset auditory loss and stereocilia disorganization
Authors: Crane Ryan , Tebbe Lars , Mwoyosvi Maggie L. , Al-Ubaidi Muayyad R. , Naash Muna I. 
Published: September 2023

AbstractUsher syndrome (USH) is the leading cause of combined deafness and blindness, with USH2A being the most prevalent form. The mechanisms responsible for this debilitating sensory impairment remain unclear. This study focuses on characterizing the auditory phenotype in a mouse model expressing the c.2290delG mutation in usherin equivalent to human frameshift mutation c.2299delG. Previously we described how this model reproduces patient’s retinal phenotypes. Here, we present the cochlear phenotype, showing that the mutant usherin, is expressed during early postnatal stages. The c.2290delG mutation results in a truncated protein that is mislocalized within the cell body of the hair cells. The knock-in model also exhibits congenital hearing loss that remains consistent throughout the animal’s lifespan. Structurally, the stereocilia bundles, particularly in regions associated with functional hearing loss, are disorganized. Our findings shed light on the role of usherin in maintaining structural support, specifically in longer inner hair cell stereocilia, during development, which is crucial for proper bundle organization and hair cell function. Overall, we present a genetic mouse model with cochlear defects associated with the c.2290delG mutation, providing insights into the etiology of hearing loss and offering potential avenues for the development of effective therapeutic treatments for USH2A patients.
Copper-catalyzed intermolecular formal (5 + 1) annulation of 1,5-diynes with 1,2,5-oxadiazoles
Authors: Chen Can-Ming , Yang Ye-Nan , Kong Yin-Zhu , Zhu Bo-Han , Qian Peng-Cheng , Zhou Bo , Ye Long-Wu 
Published: September 2023

AbstractOne-carbon homologation reactions based on one-carbon insertion into the N−O bond of heterocycles have received tremendous interest over the past decades. However, these protocols have to rely on the use of hazardous and not easily accessible diazo compounds as precursors, and examples of the relevant asymmetric catalysis have not been reported. Here we show that a copper-catalyzed intermolecular formal (5 + 1) annulation of 1,5-diynes with 1,2,5-oxadiazoles involving one-carbon insertion into the heterocyclic N−O bond via non-diazo approach. This method enables practical and atom-economic synthesis of valuable pyrrole-substituted oxadiazines in generally moderate to good yields under mild reaction conditions. In addition, the possibility of such an asymmetric formal (5 + 1) annulation also emerges.
Spiral spin cluster in the hyperkagome antiferromagnet Mn3RhSi
Authors: Shamoto Shin-ichi , Yamauchi Hiroki , Iida Kazuki , Ikeuchi Kazuhiko , Hall Amelia Elisabeth , Chen Yu-Sheng , Lee Min Kai , Balakrishnan Geetha , Chang Lieh-Jeng 
Published: September 2023

AbstractLocal spin correlation orders emerge in a paramagnetic state, with notable examples such as the partial order, cooperative paramagnetism, and soliton spin liquid. The noncentrosymmetric intermetallic antiferromagnet Mn3RhSi also exhibits the local spin correlation order in the paramagnetic state as magnetic short-range order in a wide temperature range. Here, we show that the local spin correlation order has a spiral structure by neutron scattering measurement of a Mn3RhSi single crystal. The possible origins of the magnetic cluster formation are discussed in terms of the Lifshitz invariant and the Griffiths phase, and compared with the room-temperature skyrmion phase of Co7Zn7Mn6 and non-Fermi liquid behavior of β-Mn.
Asteroseismic age estimate of the open cluster NGC 6866 using Kepler and Gaia
Authors: Brogaard K. , Arentoft T. , Miglio A. , Casali G. , Thomsen J. S. , Tailo M. , Montalbán J. , Grisoni V. , Willett E. , Stokholm A. , Grundahl F. , Stello D. , Sandquist E. L. 
Published: September 2023

Context. Asteroseismic investigations of solar-like oscillations in giant stars allow for the derivation of their masses and radii. For members of open clusters, this allows us to obtain an age estimate of the cluster that is expected to be identical to the age estimate given by the colour-magnitude diagram, but independent of the uncertainties that are present for that type of analysis. Thus, a more precise and accurate age estimate can be obtained.
Aims. We aim to identify and measure the asteroseismic properties of oscillating giant members of the open cluster NGC 6866 and utilise them for a cluster age estimate. Model comparisons also allow constraints to be placed on the stellar physics. Here, we investigate the efficiency of convective-core overshoot during the main sequence evolution, which has a significant influence on the age estimations for these relatively massive giants. The effects of rotation and core overshoot are similar, but not identical, and so, we also investigated the potential of our measurements to distinguish between these effects.
Methods. We identified six giant members of NGC 6866 via photometry, proper motions, and parallaxes from Gaia, and spectroscopic literature measurements. These were combined with asteroseismic measurements, which we derived using photometric data from the Kepler mission for five of the stars. Comparisons to stellar-model isochrones constrained the convective-core overshoot and enable a more precise and accurate age estimate than previously possible.
Results. A significant amount of differential reddening is found for NGC 6866. Asteroseismology establishes the helium-core burning evolutionary phase for the giants, which have a mean mass of 2.8 M⊙. Their radii are significantly smaller than predicted by current 1D stellar models unless the amount of convective-core overshoot on the main sequence is reduced to αov ≤ 0.1 ⋅ Hp in the step-overshoot description. Our measurements also suggest that rotation has affected the evolution of the stars in NGC 6866 in a way that is consistent with 3D simulations, but not with current 1D stellar models. The age of NGC 6866 is estimated to be 0.43 ± 0.05 Gyr, which is significantly younger and more precise than most previous estimates.
Conclusions. We derive a precise cluster age while constraining convective-core overshooting and the effects of rotation in the stellar models. A comparison to age estimates from machine learning methods of the same and similar giant stars uncovers potential biases for automated asteroseismic and non-asteroseismic age estimates of helium-core burning stars.
Treatment of Early Breast Cancer
Authors: Untch Michael , Banys-Paluchowski Maggie , Brucker Sara Y. , Budach Wilfried , Denkert Carsten , Ditsch Nina , Fasching Peter A. , Haidinger Renate , Heil Jörg , Jackisch Christian , Janni Wolfgang , Kolberg Hans-Christian , Krug David , Loibl Sibylle , Lüftner Diana , van Mackelenbergh Marion , Radosa Julia C. , Reimer Toralf , Welslau Manfred , Würstlein Rachel , Harbeck Nadia , Huober Jens 
Published: September 2023

AbstractThis yearʼs 18th St. Gallen (SG) consensus conference on the treatment of early breast cancer (SGBCC: St. Gallen International Breast Cancer Conference) focused on practice-oriented
questions. The individual situation and risk-benefit assessment were discussed in great detail. As in previous years, a German working group of leading breast cancer experts presented the
results of the international SGBCC 2023 against the background of German treatment recommendations – especially the updated treatment recommendations of the Arbeitsgemeinschaft
Gynäkologische Onkologie e. V. (AGO) – for everyday clinical practice in Germany. The German treatment recommendations of AGO are based on the current evidence. The comparison with the
clinical approach in Germany has proven useful, as the SGBCC panel consists of experts from different countries and disciplines. That is why country-specific characteristics can be
incorporated into the SGBCC recommendations.
The Underutilization of Forensic Microbiology: A Narrative Review
Authors: Saha Rumpa , Kaushik Stuti , Kumar Arvind , Choudhary Swapnil 
Published: September 2023

One of the main reasons of death in India is infection. At many centers, determining the infectious cause of death during autopsy is not regularly done. Although it is still a neglected field, postmortem microbiology has the potential to be a crucial tool for identifying the reason and circumstances of unexpected death. In addition to its use in forensic autopsies and medicolegal investigations, this tool can help with the detection of novel pathogen presentations, estimation of drug resistance, identification of bioterrorism agents, and a better understanding of infectious diseases like toxic shock syndrome, Human Immunodeficiency Virus (HIV), and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In India, there has not been much use of microbiology in postmortem, and there is a dearth of specific guidelines or recommendations by regulatory agencies.
In an effort to highlight the value of microbiology in postmortem, this narrative review focusses on suggestions made by a group of academicians from Europe in February 2016 and how they may be used in an Indian context. Based on the Indian Council of Medical Research and the Centers for Disease Control and Prevention standards, we have briefly discussed about postmortem in coronavirus disease 2019 related deaths.