bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting the pro-oxidant activity of copper: interplay of ascorbate, cysteine, and glutathione
Authors: Falcone Enrico , Stellato Francesco , Vileno Bertrand , Bouraguba Merwan , Lebrun Vincent , Ilbert Marianne , Morante Silvia , Faller Peter 
Published: June 2023

Abstract
Copper (Cu) is essential for most organisms, but it can be poisonous in excess, through mechanisms such as protein aggregation, trans-metallation, and oxidative stress. The latter could implicate the formation of potentially harmful reactive oxygen species (O2•−, H2O2, and HO•) via the redox cycling between Cu(II)/Cu(I) states in the presence of dioxygen and physiological reducing agents such as ascorbate (AscH), cysteine (Cys), and the tripeptide glutathione (GSH). Although the reactivity of Cu with these reductants has been previously investigated, the reactions taking place in a more physiologically relevant mixture of these biomolecules are not known. Hence, we report here on the reactivity of Cu with binary and ternary mixtures of AscH, Cys, and GSH. By measuring AscH and thiol oxidation, as well as HO• formation, we show that Cu reacts preferentially with GSH and Cys, halting AscH oxidation and also HO• release. This could be explained by the formation of Cu-thiolate clusters with both GSH and, as we first demonstrate here, Cys. Moreover, we observed a remarkable acceleration of Cu-catalyzed GSH oxidation in the presence of Cys. We provide evidence that both thiol-disulfide exchange and the generated H2O2 contribute to this effect. Based on these findings, we speculate that Cu-induced oxidative stress may be mainly driven by GSH depletion and/or protein disulfide formation rather than by HO• and envision a synergistic effect of Cys on Cu toxicity.
DNA strand break levels in cryopreserved mononuclear blood cell lines measured by the alkaline comet assay: results from the hCOMET ring trial
Authors: Møller Peter , Azqueta Amaya , Rodriguez-Garraus Adriana , Bakuradze Tamara , Richling Elke , Bankoglu Ezgi Eyluel , Stopper Helga , Claudino Bastos Victoria , Langie Sabine A S , Jensen Annie , Ristori Sara , Scavone Francesca , Giovannelli Lisa , Wojewódzka Maria , Kruszewski Marcin , Valdiglesias Vanessa , Laffon Blanca , Costa Carla , Costa Solange , Paulo Teixeira João , Marino Mirko , Del Bo Cristian , Riso Patrizia , Zheng Congying , Shaposhnikov Sergey , Collins Andrew 
Published: June 2023

Abstract
The comet assay is widely used in biomonitoring studies for the analysis of DNA damage in leukocytes and peripheral blood mononuclear cells. Rather than processing blood samples directly, it can be desirable to cryopreserve whole blood or isolated cells for later analysis by the comet assay. However, this creates concern about artificial accumulation of DNA damage during cryopreservation. In this study, 10 laboratories used standardized cryopreservation and thawing procedures of monocytic (THP-1) or lymphocytic (TK6) cells. Samples were cryopreserved in small aliquots in 50% foetal bovine serum, 40% cell culture medium, and 10% dimethyl sulphoxide. Subsequently, cryopreserved samples were analysed by the standard comet assay on three occasions over a 3-year period. Levels of DNA strand breaks in THP-1 cells were increased (four laboratories), unaltered (four laboratories), or decreased (two laboratories) by long-term storage. Pooled analysis indicates only a modest positive association between storage time and levels of DNA strand breaks in THP-1 cells (0.37% Tail DNA per year, 95% confidence interval: −0.05, 0.78). In contrast, DNA strand break levels were not increased by cryopreservation in TK6 cells. There was inter-laboratory variation in levels of DNA strand breaks in THP-1 cells (SD = 3.7% Tail DNA) and TK6 reference sample cells (SD = 9.4% Tail DNA), whereas the intra-laboratory residual variation was substantially smaller (i.e. SD = 0.4%–2.2% Tail DNA in laboratories with the smallest and largest variation). In conclusion, the study shows that accumulation of DNA strand breaks in cryopreserved mononuclear blood cell lines is not a matter of concern.
Exploring the clinical utility of a brief screening measure of unmet supportive care needs in people with high-grade glioma
Authors: Campbell Rachel , Faris Mona , Shaw Joanne , Halkett Georgia K B , Legge Dianne , Koh Eng-Siew , Nowak Anna K , Agar Meera R , Ownsworth Tamara , Pike Kerryn E , Chan Raymond J , Dhillon Haryana M 
Published: June 2023

Abstract

Background
People living with high-grade glioma (HGG) have diverse and complex needs. Screening aims to detect patients with some level of unmet need requiring triaging and further assessment. However, most existing measures of unmet need are not suitable for screening in this population due to their length. We aimed to explore the clinical utility of a brief screening tool (SCNS-ST9) in people with HGG in detecting unmet needs.

Methods
Secondary analysis of data collected in a prospective cohort study of 116 people with HGG who completed the Supportive Care Needs Survey (SCNS-SF34) and a brain cancer-specific needs survey (BrTSCNS) during chemoradiation (T1) and 6 months later (T2). The SCNS-ST9 contains a subset of 9 items from the SCNS-SF34. Data analysis determined the number of individuals with unmet needs on the SCNS-SF34 and the BrTSCNS, not identified as having some level of need by the SCNS-ST9.

Results
Overall, 3 individuals (T1: 2.6% [3/116]; T2: 4.8% [3/63]) at each time point reported other unmet needs on the SCNS-SF34 that were missed by the SCNS-ST9. Domain-specific screening items missed a higher proportion of individuals (3.2%–26%), particularly in the psychological and health systems domains. Only 1 individual with brain cancer-specific needs was missed by SCNS-ST9 overall.

Conclusion
Findings demonstrate the sensitivity and clinical utility of a brief screening tool (SCNS-ST9) of unmet needs in people with HGG. Routine use of this screening tool, supported by clinical pathways, may improve access to support services, potentially reducing the burden of disease for these patients.
Stretchable polymer composites with ultrahigh piezoelectric performance
Authors: Tang Tongxiang , Shen Zhonghui , Wang Jian , Xu Shiqi , Jiang Jiaxi , Chang Jiahui , Guo Mengfan , Fan Youjun , Xiao Yao , Dong Zhihao , Huang Houbing , Li Xiaoyan , Zhang Yihui , Wang Danyang , Chen Long-Qing , Wang Ke , Zhang Shujun , Nan Ce-Wen , Shen Yang 
Published: June 2023

ABSTRACT
Flexible piezoelectric materials capable of withstanding large deformation play key roles in flexible electronics. Ferroelectric ceramics with a high piezoelectric coefficient are inherently brittle, whereas polar polymers exhibit a low piezoelectric coefficient. Here we report a highly stretchable/compressible piezoelectric composite composed of ferroelectric ceramic skeleton, elastomer matrix and relaxor ferroelectric-based hybrid at the ceramic/matrix interface as dielectric transition layers, exhibiting a giant piezoelectric coefficient of 250 picometers per volt, high electromechanical coupling factor keff of 65%, ultralow acoustic impedance of 3MRyl and high cyclic stability under 50% compression strain. The superior flexibility and piezoelectric properties are attributed to the electric polarization and mechanical load transfer paths formed by the ceramic skeleton, and dielectric mismatch mitigation between ceramic fillers and elastomer matrix by the dielectric transition layer. The synergistic fusion of ultrahigh piezoelectric properties and superior flexibility in these polymer composites is expected to drive emerging applications in flexible smart electronics.
Effects of therapeutic lifestyle change diets on blood lipids, lipoproteins, glycemic parameters, and blood pressure: a systematic review and meta-analysis of clinical trials
Authors: Keshani Mahdi , Feizi Awat , Askari Gholamreza , Sharma Manoj , Bagherniya Mohammad 
Published: June 2023

Abstract

Context
Cardiovascular disease is the leading cause of death worldwide. Low-calorie, low-fat therapeutic diets (TDs) developed by the US National Cholesterol Education Program, ie, the Step I and II diets and the therapeutic lifestyle changes diet, are approximately similar and are the initial therapeutic interventional approaches for lifestyle modification.

Objective
This systematic review with meta-analysis was undertaken to evaluate the effects of TDs diet on blood lipids, apolipoprotein A-1, apolipoprotein B, blood pressure, fasting blood glucose, and insulin.

Data Sources
A comprehensive search of the PubMed/MEDLINE, Web of Science, Scopus, and Google Scholar databases until October 2022 was performed to identify clinical trials investigating the effects of TDs on the aforementioned parameters.

Data Extraction
One investigator screened the records and extracted data, and another reviewed the extracted data.

Data Analysis
A total of 910 records were retrieved. After records were screened for eligibility, 34 clinical trials met the inclusion criteria. The pooled analysis from the random-effects model revealed a significant reduction in total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein A-1, and apolipoprotein B in the TD intervention group vs the control group. The overall effects of TDs on fasting blood glucose, insulin, and blood pressure were not significant, but the results of subgroup analysis revealed a significant reduction in fasting blood glucose with the Step II diet and an intervention duration of more than 24 weeks. For blood pressure, the Step I diet and an intervention duration of more than 24 weeks resulted in significant reduction. There was no evidence of publication bias, but strong heterogeneity was observed.

Conclusion
Therapeutic diets have promising effects on lipid profile parameters, glycemic indexes, and blood pressure, which can promote cardiovascular health.

Systematic Review Registration
PROSPERO registration no. CRD42021259355.
Late Nineteenth Century to 1990
Authors: Logan Wayne A. 
Published: June 2023

Abstract
This chapter surveys a period of considerable length, from the late nineteenth century to 1990, a time marked by major retrenchment in the coverage of the clause compared to prior decades. Supreme Court majorities frequently rejected ex post facto challenges, often on the basis of their narrow interpretation of what qualified as punishment, the necessary precondition for an ex post facto challenge identified by Calder. Moreover, and of critical importance, the court laid the groundwork for its first test for determining whether a legal sanction is punitive in nature, a test that in substantial form continues to this day.
The 1990s to the Present
Authors: Logan Wayne A. 
Published: June 2023

Abstract
This chapter examines the court’s modern interpretation and application of the clause. The chapter begins where the previous chapter ended: the 1990s, a time of unprecedented “get tough” criminal justice policies, especially concerning previously convicted sex offenders. In two major decisions, Kansas v. Hendricks (1997) and Smith v. Doe (2003), the court rejected ex post facto challenges to the likely lifetime involuntary confinement of a sex offender, and the requirement that sex offenders provide government authorities personal identifying information (e.g., work address, vehicle information) that is then provided to the public. In the decisions, the court refined the analytic rubric used to decide whether a sanction is punitive, and deemed both laws non-punitive in nature. During the time period, the court also addressed challenges to other earmarks of penal populism, including laws retroactively lengthening prison sentences and lessening availability of parole for inmates. The challenges, which unquestionably concerned criminal laws, met with mixed results. Notably, the period also witnessed two instances of the court, by narrow 5-4 majorities, granting relief to petitioners. In the first, Carmell v. Texas (2000), the court resuscitated Calder category four, prohibiting retroactive changes in evidence, which the court had before seemingly jettisoned. In the other, Stogner v. California (2003), the court granted relief on the basis of Calder category two, invalidating a law retroactively extending an expired statute of limitations for a child sexual abuse prosecution.
Imagine, If You Will: Ekphrasis and the Senses in the Sanctuary
Authors: Lieber Laura S. 
Published: June 2023

Abstract
This chapter focuses on two related topics: how poets verbally fashioned the multisensory elements of these poems and to what effect; and how the textual evocations of sight complemented the rich visual context of ancient churches and synagogues. The groundwork for this twofold analysis is established through a close consideration of the importance of visuality (ekphrasis, lit., “setting before the eyes”) in the rhetorical handbooks (progymnasmata) of late antiquity, which signal the importance of such oratorical-rhetorical techniques far beyond the training of orators. The analysis then turns to consider techniques by which liturgical poets from all three traditions appeal to the sense of sight, as well as other senses, and the role of embodiment more generally. With those literary and performative exemplars in mind, the chapter then briefly considers how images from the performative environment might have resonated with or reinforced elements from the texts. Throughout the chapter, the interlocking dynamics between physical experience and the power of imagination are kept in mind.
Biopolitical Ethics in Global Cinema
Authors: Jeong Seung-hoon 
Published: June 2023

Abstract
This book is a critical attempt to approach world cinema in a new global frame that updates the national frame of territorial cinemas and the transnational frame of their interplay. The global frame implies the reintegration of border-crossing forces onto the postpolitical plane of troubled globalization with two ethical facets: the soft ethical inclusion of differences in multicultural, neoliberal systems and their hard ethical symptoms of fundamentalist exclusion and terror. Reflecting both, global cinema is formulated as staging crucial challenges that today’s globalism and its antinomies bring to the notions of subjectivity and community. Many films indeed depict the antagonism between the inclusive global system and its excluded remnants, allegorizing the impossible political change in various modes of catastrophe and nihilism. A global community often takes on a totalized network of sovereign violence and (counter)terror stuck in the impasse of utopian imagination. Yet some films suggest alternative ethics irreducible to collective politics when abject figures, deprived of social subjectivity and rights, become contingent agents of existential ‘gift-giving’ by fostering commonality without community, solidarity without unity. The psychoanalytic notion of abjection is redefined here as both the biopolitical mode of bare life and its potential for the ethical agency that opens atopian, if not utopian, networking on the edge of the global regime beyond the problematic ‘soft/hard’ ethics of tolerance/violence or pity/hate. This precarious yet precious abject agency is explored through a vast net of globally circulating contemporary films and a core cluster of political, ethical, and psychoanalytic philosophies.
Introduction
Authors: Jeong Seung-hoon 
Published: June 2023

Abstract
The book begins by introducing three microhistorical waves of globalization over the past three decades and illuminating their systems of inclusion (liberal democracy, transnational capitalism, network technology) that generate symptoms of exclusion (refugee crises, economic polarization, anti-immigration). These two aspects resonate with the postpolitical double ethics of multicultural tolerance and terroristic justice, underlying the catastrophic antagonism between a global community and its remainder. The introduction addresses the latter as ‘the abject’ from biopolitical and ethical angles and explores ‘abject agency’ in various directions through ‘global cinema.’ Accordingly, world cinema studies may be remapped to update its national/transnational frames to a global frame. Contemporary local films appear here as reflecting global phenomena in terms of biopolitical abjection and ethical ‘atopia.’ This introduction sketches a world map of significant directors to explore in this frame, including both global Hollywood and global auteurs.
Sovereign Agents’ Biopolitical Abjection in the Spy Film
Authors: Jeong Seung-hoon 
Published: June 2023

Abstract
Biopolitically, abjection is the community’s supralegal operation of hard-ethical sovereignty. The abject can for this reason become an agent to rejoin or resist the community. Chapter 3 explores this abject agency in global mainstream cinema, focusing on the spy genre, especially the James Bond series. Skyfall, for example, signals the crisis of the secret agent’s identity against the post-9/11 backdrop of schizophrenic digital terror. Bond and his enemy here are both internally excluded from their agency, MI6, and this ‘abjection’ leads to terrorist revenge and sovereign reaffirmation respectively. Comparable is Jason Bourne, the former CIA agent in the Bourne series. He undergoes similar abjection yet becomes neither a terrorist nor a sovereign agent but a symptom of perpetual mind game. This comparison enables a cognitive mapping of the contemporary spy genre regarding today’s global system of sovereignty and abjection.
From the Disaster Genre to the Cinema of Catastrophe
Authors: Jeong Seung-hoon 
Published: June 2023

Abstract
Chapter 5 addresses the catastrophic effects of the global system that aggravate the political, economic, and natural environments of the world, by mapping a myriad of related films. The discussion centers on biopolitical catastrophes and their cinematic reflections in the beginning and then develops into theorizing the notions of catastrophe and disaster, especially regarding the sublime in its aesthetic and ethical senses. Catastrophe overturns our frame of reference with its sublime power and scale, but it is often reduced to an amusing spectacle or a solvable problem in the disaster genre. The task is to elicit implications of catastrophe from the disaster genre and explore the ‘cinema of catastrophe,’ including films that challenge the genre’s conventions.
Human History in (Post)Apocalyptic Cinema
Authors: Jeong Seung-hoon 
Published: June 2023

Abstract
Chapter 6 shifts our focus from disaster to catastrophe and further to apocalypse, reflecting on the complexity of (post)apocalyptic films. Among them, the chapter scrutinizes Snowpiercer, in which a postapocalyptic ecosystem of biopower leaves no exit, after a periodically programmed failed revolution, but the divine violence of annihilation. The spectacular depiction of this second apocalypse betrays the failure of imagining a utopian alternative while opening a potential new beginning of humanity. Then the film’s premise is integrated into an exploration of what would happen in such a situation via the Mad Max series. A postapocalyptic time continues here in the way of revealing nothing but the same past without redemption. The saga’s loop of historical déjà vu recycles primitive stages of human history in postmodern fusion. In this way, it reflects our posthistorical temporality with revolutions recurring yet bringing about no real change.
The Abject as Neighbor beyond Cultural Mediation
Authors: Jeong Seung-hoon 
Published: June 2023

Abstract
Chapter 11 further develops the ethics of the gift by comparatively reading The Edge of Heaven and The Promise, both of which are based on the Abraham-Isaac story. Abraham’s sacrifice of Isaac epitomizes one’s singular relationship with God beyond community, but the Abraham figures in the films (global Europeans) give themselves to the abject Isaac figures (migrant Muslims) through self-abjection. This becoming-abject as gift forms solidarity among the abject as ‘faceless’ strangers. And the self-other unit in Levinas’s ethics of the other’s face can be destabilized when the faceless Third takes the other’s place (repeatedly). The chapter addresses this new other, neither friend nor enemy, a ‘neighbor’ with whom one can walk side by side rather than face to face beyond cultural mediation or communal identity. Levinasian infinity is thus reframed in this network of neighboring as an alternative to the soft-ethical networking in the global system.
Atopian Networking and Positive Nihilism
Authors: Jeong Seung-hoon 
Published: June 2023

Abstract
Finally, Chapter 12 elaborates on the ethics of atopia through the lens of nihilism. The argument first illuminates the negative, passive, and active phases of nihilism in the global frame of politics/postpolitics and community/network. Children of Men, here, signals a positively active mode of nihilism emerging through an atopian network of gift-giving abject agents. Himizu further draws our attention to the fundamental ground of this atopian ethics, where one can embrace the void of life with only life’s self-transcending potential. The chapter derives ‘positive nihilism’ from this existentialist perspective and refines the new ethics of global cinema beyond the postpolitical framework of double ethics. Cinema sheds light on the abject inevitably generated in any political community, however utopian, and raises questions or possibilities irreducible to politics. This atopian nature of cinema makes it an ethical art.
Evaluating Comics
Authors: Pratt Henry John , Shaffert Kurt F. 
Published: June 2023

Abstract
This chapter focuses on what makes a comic good or bad, and whether there are any general principles that can be adopted that yield good judgments of comparative value for comics. While some degree of relativism in the evaluation of comics is inevitable, not every evaluation of comics is of equal quality. Following David Hume, the standard of taste for comics is fixed by expert critics who are particularly attuned to the four types of properties that make comics valuable: narrative, pictorial, historical, and referential. A subjectivist account of the value of particular comics is advanced, on which these properties have in common the capacity to afford valuable experiences. Finally, an explanation is offered for how the comics world came to select these properties as evaluatively relevant rather than others, tying the answer to medium specificity.
So Many Trans Kids—What’s Going On?
Authors: Key Aidan 
Published: June 2023

Abstract
Chapter 1 of Trans Children in Today’s Schools gives us an introduction to the increasing presence and visibility of gender-diverse children today, provides historical background for the societal treatment of transgender people, and explores the shift in our understanding of gender identity and development in children. As we respond to this shift toward better supporting trans children in their development, we struggle to fully embrace a gender-expansive approach as it impinges upon restrictive, yet familiar, gender norms. This chapter presents the author’s extensive experience working with parents and educators to improve K–12 practices for gender inclusion, and poses the question which frames the entire book: How do we create a gender-inclusive environment for every child and what are the implications for schools today?
Supporting Trans Children
Authors: Key Aidan 
Published: June 2023

Abstract
Chapter 2 explores the historical misunderstanding and misrepresentation of gender-diverse people, the harm this misunderstanding has caused societally and toward individuals, and the ways in which this reverberates today as we approach children who express gender differences. Readers will better understand the origins of resistance and apprehension so often experienced by parents and educators alike, and subsequently gain a greater perspective of how to engage with others in a more sympathetic and nonjudgmental manner. This chapter lays the foundation for engaging with and implementing today’s best practices for transgender and other gender-diverse youth as educators and parents shift to a model of support and inclusion.