bluuebunny/crossref_metadata_2025_split huggingface dataset:
The social isolation enforced by the COVID-19 pandemic reduces the Health-Related Quality of Life score in the adult population of Metropolitan Lima, Peru
Authors: Morales-Ancajima Valeria C. , Vasquez-Velasquez Cinthya , De la Cruz Melany , Marull Maria , Tapia Vilma , Gonzales Gustavo F. 
Published: January 2023

Background: The objective of this study was to determine the association between health-related quality of life (HRQoL) in adults in Metropolitan Lima, Peru, with experienced social isolation during the coronavirus disease 2019 (COVID-19) pandemic regardless of if the person was infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adjusted by age, sex and body mass index (BMI). Methods: This cross-sectional study evaluated 256 men and 382 women living in Metropolitan Lima, who were administered the Health-Related Quality of Life (HRQoL) questionnaire (SF-20) virtually to assess their health-related quality of life. A Generalized Linear Model (GLM) was used to determine the relationship between HRQoL with BMI, sex, age, COVID-19 status and obligatory social isolation; with a significance level of p<0.05. Results: Obesity (beta coefficient, 95%CI [95% confidence interval]: -262 – -116), female sex (beta coefficient, 95%CI: -151 – -59), the longest time of mandatory social confinement (beta coefficient, 95%CI: -6.8 – -0.2), and the existence of chronic disease (beta coefficient, 95%CI: -147 – -44) were associated with a low total score of the HRQoL questionnaire. Conclusions: Mandatory social confinement may have harmed the perception of health-related quality of life.
The missing piece. The perceived marginalization of CSOs and HRGs in SOSTs’ decision-making processes: a review
Authors: De Sabbata Lorenzo , Laterza Riccardo , Del Bianco Daniele , Ferrari Olivia , Benedetti Ezio 
Published: January 2023

This review represents the first contribution of a research diptych which stems from the activities implemented in the framework of the H2020 ARESIBO project (Augmented Reality Enriched Situation awareness for Border security). The general objective of ARESIBO is to improve the efficiency of border surveillance systems by providing the operational teams, as well as the tactical command and control level with accurate and comprehensive information related to border control considering different issues and perspectives. These perspectives also include the analysis of the level of engagement and the (possible) enhancement of citizens’ involvement in the development and decision making related to border surveillance. The principal human rights and migration International Organisations (IOs), as well as EU institutions dealing with security and external borders (i.e., Frontex), agree and state that human rights groups (HRGs) and civil society organisations (CSOs) should be more involved and integrated in border surveillance. That stated, the main goal of this paper is to analyse this perceived marginalisation of CSOs and HRGs, as it emerges from several HRGs’ and CSOs’ statements on that regard in order to explore the reasons of this perceived marginalisation, as well as the elements that on the contrary seem to make this marginalisation less sustantial. The results of this systematic review in the framework of ARESIBO led to the elaboration of an innovative participatory model that will be analysed in detail in the second article of this research diptych, entitled “Towards the engagement of citizens in SOSTs decision-making: participatory models setting a common ground for border surveillance and respect of fundamental rights. The case of ARESIBO H2020 project”.
A dynamic perspective on the evolution of perceived stress levels in Switzerland: drivers before and during the COVID-19 pandemic
Authors: Klaas Hannah S. , Kuhn Ursina , Ryser Valérie-Anne , Refle Jan-Erik , Tillmann Robin , Voorpostel Marieke 
Published: January 2023

As a major socio-historical event affecting different aspects of life, the COVID-19 pandemic presents a unique opportunity to study how different population groups adapt. We investigate the impact of this crisis on the evolution of perceived stress in the short and medium term in Switzerland, using data of the Swiss Household Panel from 2016 to early 2021, which include annual measures of perceived stress and a study between waves, conducted in May and June 2020 at the end of the first semi-lockdown. Using the longitudinal structure of the data with pre-crisis measurements, we estimate pooled OLS, fixed effects and first difference models, which include socio-demographic variables, life events, socio-economic status, work-related variables, stress-reducing resources and restrictions in place.
Results for the overall population show a continuous increase in stress levels between 2016 and 2019 and a stress reduction right after the first semi-lockdown followed by a return to pre-pandemic levels. Privileged groups with higher levels of stress before the pandemic were most likely to reduce perceived stress. Characteristics related to more favourable trajectories include stable or improved financial situations and high levels of education (short-term effects), and high-pressure jobs and working hours (short- and medium-term effects). Our analyses reveal the importance of resources, such as social relations and work–life balance, to individuals’ management of the effects of the pandemic.
Our results show that the effects of the pandemic on perceived stress are context-specific. They underline the importance of longitudinal analyses to understand the complexity of vulnerability and adaptation processes.
Konstruktion einer Methode zur datenbasierten Schätzung von Logistikprozessdauern als Aufgabe im Projektmanagement
Authors: Kusturica Wibke 
Published: January 2023

ZusammenfassungDie für die Planung des Materialflusses relevanten Fertigungsprozesse lassen sich sehr genau planen, beispielsweise über die Leistung der Maschine (Durchsatz je Zeiteinheit). Bei der Planung eines Projektes spielen logistische Prozesse, die zu den Kernprozessen eines Unternehmens gehören, eine wichtige Rolle. Jedoch werden sie meist nur grob terminiert und mit großen Puffern kalkuliert. Dies kann zu einer Verlängerung der Projektdauer führen. Für eine genauere Terminierung eines Projektes ist es daher entscheidend, die Dauer der logistischen Prozesse mindestens in dem Maße wie die Fertigungsprozesse zu ermitteln, um das Risiko einer Projektverzögerung zu minimieren.In diesem Beitrag wird deshalb eine Methode zur datenbasierten Schätzung von Prozessdauern mit dem Ziel der Wiederverwendung von Projektwissen vorgestellt, die es dem Projektmanagement ermöglichen soll, Dauern von logistischen Prozessen präziser zu schätzen als das aktuell basierend auf Erfahrungswissen erfolgt. Besonderes Augenmerk liegt dabei auf der Herleitung der Entwurfsaktivitäten. Durch die Anwendung der Methode soll das Projektmanagement von einer genaueren, datenbasierten Schätzung von (Logistik‑)Prozessdauern profitieren und so entstandenes Wissen über einen Ontologieansatz wiederverwenden können.
Prediction of venous thromboembolism incidence in the general adult population using two published genetic risk scores
Authors: Folsom Aaron R. , Tang Weihong , Hong Ching-Ping , Rosamond Wayne D. , Lane John A. , Cushman Mary , Pankratz Nathan 
Published: January 2023

Introduction
Most strategies for prevention of venous thromboembolism focus on preventing recurrent events. Yet, primary prevention might be possible through approaches targeting the whole population or high-risk patients. To inform possible prevention strategies, population-based information on the ability of genetic risk scores to identify risk of incident venous thromboembolism is needed.

Materials and methods
We used proportional hazards regression to relate two published genetic risk scores (273-variants versus 5-variants) with venous thromboembolism incidence in the Atherosclerosis Risk in Communities Study (ARIC) cohort (n = 11,292), aged 45–64 at baseline, drawn from 4 US communities.

Results
Over a median of 28 years, ARIC identified 788 incident venous thromboembolism events. Incidence rates rose more than two-fold across quartiles of the 273-variant genetic risk score: 1.7, 2.7, 3.4 and 4.0 per 1,000 person-years. For White participants, age, sex, and ancestry-adjusted hazard ratios (95% confidence intervals) across quartiles were strong [1 (reference), 1.30 (0.99,1.70), 1.85 (1.43,2.40), and 2.58 (2.04,3.28)] but weaker for Black participants [1, 1.05 (0.63,1.75), 1.37 (0.84,2.22), and 1.32 (0.80,2.20)]. The 5-variant genetic risk score showed a less steep gradient, with hazard ratios in Whites of 1, 1.17 (0.89,1.54), 1.48 (1.14,1.92), and 2.18 (1.71,2.79). Models including the 273-variant genetic risk score plus lifestyle and clinical factors had a c-statistic of 0.67.

Conclusions
In the general population, middle-aged adults in the highest quartile of either genetic risk score studied have approximately two-fold higher risk of an incident venous thromboembolism compared with the lowest quartile. The genetic risk scores show a weaker association with venous thromboembolism for Black people.
Bacterial vs viral etiology of fever: A prospective study of a host score for supporting etiologic accuracy of emergency department physicians
Authors: Mor Meirav , Paz Meital , Amir Lisa , Levy Itzhak , Scheuerman Oded , Livni Gilat , Guetta-Oz Claire , Yochpaz Sivan , Berant Ron , Schwartz Rama , Niv Omer , Singer Dana , Ashkenazi Shai , Waisman Yehezkel 
Published: January 2023

Background
A host-protein score (BV score) that combines the circulating levels of TNF-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein 10 (IP-10) and C-reactive protein (CRP) was developed for distinguishing bacterial from viral infection. This study assessed the potential of the BV score to impact decision making and antibiotic stewardship at the emergency department (ED), by comparing BV score’s performance to physician’s etiological suspicion at patient presentation.

Methods
Rosetta study participants, aged 3 months to 18 years with febrile respiratory tract infection or fever without source, were prospectively recruited in a tertiary care pediatric ED. 465 patients were recruited, 298 met eligibility criteria and 287 were enrolled. ED physician’s etiological suspicion was recorded in a questionnaire. BV score was measured retrospectively with results interpreted as viral, bacterial or equivocal and compared to reference standard etiology, which was adjudicated by three independent experts based on all available data. Experts were blinded to BV scores.

Results
Median age was 1.3 years (interquartile range 1.7), 39.7% females. 196 cases were reference standard viral and 18 cases were reference standard bacterial. BV score attained sensitivity of 88.9% (95% confidence interval: 74.4–100), specificity 92.1% (88.1–96.0), positive predictive value 53.3% (35.5–71.2) and negative predictive value 98.8% (97.1–100). Positive likelihood ratio was 11.18 (6.59–18.97) and negative likelihood ratio was 0.12 (0.03–0.45). The rate of BV equivocal scores was 9.4%. Comparing physician’s suspicion to BV score and to the reference standard, and assuming full adoption, BV score could potentially correct the physician’s diagnosis and reduce error ~2-fold, from 15.9% to 8.2%.

Conclusions
BV score has potential to aid the diagnostic process. Future studies are warranted to assess the impact of real-time BV results on ED practice.
Lessons Learned From Implementing an OA Management Platform: A Case Study by Emerald Publishing & ChronosHub
Authors: Reher Ida Sofie , Jagerhorn Martin , Allen Shelley 
Published: January 2023

As a response to the growing complexities pervading the author’s journey toward OA publishing, many publishers are increasingly committed to raising the bar and creating fundamental standards to ensure a smoother, simplified author experience. Last year, Emerald Publishing and ChronosHub joined forces in a partnership committed to enhancing transparency, breaking down barriers, and supporting the authors’ transition toward a more open world.
With this presentation, we look back, reflect, and pass on our knowledge of our greatest learnings and insights obtained from the collaboration between Emerald Publishing and ChronosHub. We will explore how we managed to connect and collaborate to overcome the challenges and barriers – despite the fairly fragmented and disconnected world in which we still find ourselves. If these past years have taught us anything, it is that we rely on technology, innovation, and a strong community to ensure optimal collaboration and progress.
During the implementation, we have involved both researchers as well as other key actors from the research community in our processes in order to reach common understandings and ensure continuous progress in creating the best possible author experience.
We will also share how an OA Management platform can be leveraged for continuous learning about the customers and more pro-actively drive the publishing business. It will be a combination of applied and strategic perspectives around OA Management – from high-level visions and ambitions to concrete and hands-on recommendations.
The OA Effect - Value of Gold Open Access
Authors: Sule Sam 
Published: January 2023

At Springer Nature, we see full (Gold) OA as the best, most complete and most sustainable route to achieving the goal of having all primary research immediately available. It is why, over the past twenty years, we have put transitioning to full OA for all of the primary research we publish at the heart of our business.
This poster will address the findings from our series of white papers which, over the past few years, have built and added to the growing body of evidence demonstrating the value of Gold OA and its identification as the version of the research researchers prefer to use.
Drawing on the analysis from those white papers, the poster will look at the analysis that shows a clear advantage in reach and impact for articles published OA in hybrid journals compared to non-OA articles in the same journals, as well as an advantage for full (Gold) OA articles compared to subscription articles where an earlier article version (such as an accepted manuscript or preprint) has been self-archived in an OA repository. It will also explore the evidence provided that researchers prefer to read and cite the article version of record (VOR) with the VOR being considered the most authoritative and credible source by the majority of researchers.
Statistical Review Board Shared Across Journals Portfolio
Authors: McCormack Sarah L. 
Published: January 2023

Statistical methods in epidemiology, genetics, machine learning, and other fields overlapping with nutrition research are evolving rapidly. The editors for the American Society for Nutrition’s (ASN) 4 journals found that statisticians’ expertise was often outdated or unavailable on the peer review platform. Statisticians also appeared to decline review invitations or submit late reviews at a higher rate than other reviewers. To increase ASN editors’ access to qualified statistical reviewers, a shared, paid Statistical Review Board (SRB) was created.
Applicants were recruited beginning in September 2018 based on Editorial Board recommendations and self-identified expertise of existing authors and reviewers. Criteria across ASN’s journals were established for when an SRB review was required compared with recommended. In July 2019, 18 SRB members were appointed for a pilot term of 1-year and paid at the same rate as Associate Editors. After 1 year, ASN’s Board of Directors approved making the SRB permanent based on editor feedback and financial data. ASN editors renewed a subset of the SRB members based on number of manuscripts reviewed, compliance with deadlines, and Editorial Board feedback.
This poster will report data on SRB performance. It will also include qualifications and fields of SRB members, methods to establish uniform expectations for reviews, management of payments and workload, as well as author and editor feedback. This poster will be a mixed-learning poster appropriate for editors, society staff, and publishers.
Publishing’s Next Top Model: measuring success of new business models
Authors: Field Georgie , Utterback Andy 
Published: January 2023

For decades, publishers have relied on Article Processing Charges (APCs) to fund Open Access (OA) scholarship. However, this method has been criticized as creating unequal opportunities to participate in OA publishing. In response, many publishers have introduced new business models in an attempt to both widen access to OA publishing for all researchers, and to diversify their revenue streams.
In a mixed-model economy there will inevitably be solutions that are more successful than others, but how should we approach measuring success when there are so many different motivations at playü
Success with these new models will look different depending on the outcome that the publisher is hoping to achieve. For a ‘pay-as-you-publish’ type of model, “success” is to receive sufficient revenue to cover cost and make a profit. But what if the primary motivation for the model is to make publishing more equitable for authors, regardless of their funding situationü This challenge pushes publishers to assess the usefulness of their standard metrics, to generate new metrics, and to be willing to adjust if the information is insufficient.
In order to explore these themes this poster presents four different business models from PLOS; APCs, Community Action Publishing, Global Equity, and a flat payment model. Each model has a different motivation, different measures of success, and different challenges. We hope to open a conversation around the challenges of measuring success, and share lessons learned with other organisations looking to make the leap of launching a new model.
Real-World Evidence of Tofacinitib in Ulcerative Colitis: Short-Term and Long-Term Effectiveness and Safety
Authors: Chaparro María , Acosta Diana , Rodríguez Cristina , Mesonero Francisco , Vicuña Miren , Barreiro-de Acosta Manuel , Fernández-Clotet Agnès , Hernández Martínez Álvaro , Arroyo Maite , Vera Isabel , Ruiz-Cerulla Alexandra , Sicilia Beatriz , Cabello Tapia M. José , Muñoz Villafranca Carmen , Castro-Poceiro Jesús , Martínez Cadilla Jesús , Sierra-Ausín Mónica , Vázquez Morón Juan María , Vicente Lidón Raquel , Bermejo Fernando , Royo Vanesa , Calafat Margalida , González-Muñoza Carlos , Leo Carnerero Eduardo , Manceñido Marcos Noemi , Torrealba Leyanira , Alonso-Galán Horacio , Benítez José Manuel , Ber Nieto Yolanda , Diz-Lois Palomares M. Teresa , García María José , Muñoz José Fernando , Armesto González Edisa María , Calvet Xavier , Hernández-Camba Alejandro , Madrigal Domínguez Rosa Eva , Menchén Luis , Pérez Calle José Lázaro , Piqueras Marta , Dueñas Sadornil Carmen , Botella Belén , Martínez-Pérez Teresa de Jesús , Ramos Laura , Rodríguez-Grau María Carmen , San Miguel Elena , Fernández Forcelledo José Luis , Fradejas Salazar Paola María , García-Sepulcre Marifé , Gutiérrez Ana , Llaó Jordina , Sesé Abizanda Eva , Boscá-Watts Maia , Iyo Eduardo , Keco-Huerga Alma , Martínez Bonil Carmen , Peña González Elena , Pérez-Galindo Pablo , Varela Pilar , Gisbert Javier P. ,   on Behalf of To-ReWard Study Group
Published: January 2023

INTRODUCTION:
The objective of this study was to assess the durability, short-term and long-term effectiveness, and safety of tofacitinib in ulcerative colitis (UC) in clinical practice.

METHODS:
This is a retrospective multicenter study including patients with UC who had received the first tofacitinib dose at least 8 weeks before the inclusion. Clinical effectiveness was based on partial Mayo score.

RESULTS:
A total of 408 patients were included. Of them, 184 (45%) withdrew tofacitinib during follow-up (mean = 18 months). The probability of maintaining tofacitinib was 67% at 6 m, 58% at 12 m, and 49% at 24 m. The main reason for tofacitinib withdrawal was primary nonresponse (44%). Older age at the start of tofacitinib and a higher severity of clinical activity were associated with tofacitinib withdrawal. The proportion of patients in remission was 38% at week 4, 45% at week 8, and 47% at week 16. Having moderate-to-severe vs mild disease activity at baseline and older age at tofacitinib start were associated with a lower and higher likelihood of remission at week 8, respectively. Of 171 patients in remission at week 8, 83 (49%) relapsed. The probability of maintaining response was 66% at 6 m and 54% at 12 m. There were 93 adverse events related to tofacitinib treatment (including 2 pulmonary thromboembolisms [in patients with risk factors] and 2 peripheral vascular thrombosis), and 29 led to tofacitinib discontinuation.

DISCUSSION:
Tofacitinib is effective in both short-term and long-term in patients with UC. The safety profile is similar to that previously reported.
Cardiac Vagal Regulation Is Impeded in Children With Cyclic Vomiting Syndrome
Authors: Kolacz Jacek , Kovacic Katja , Dang Linh , Li B U.K. , Lewis Gregory F. , Porges Stephen W. 
Published: January 2023

INTRODUCTION:
The pathophysiology underlying cyclic vomiting syndrome (CVS) remains undefined. Scant data and distinct clinical features point to altered autonomic nervous system function. Autonomic signaling can be noninvasively assessed through cardiac indices of parasympathetic vagal regulation, which is reduced in children with disorders of gut-brain interaction. We aimed to examine dynamic cardiac vagal regulation in children with CVS compared with that in healthy controls (HC).

METHODS:
A total of 31 children with CVS evaluated in a tertiary care CVS center and 66 HC (ages 8–18 years) underwent cardiac autonomic function assessment. Electrocardiogram recordings were conducted during 3-minute sit/stand/sit posture challenges. The electrocardiogram-derived variables heart period, respiratory sinus arrhythmia (RSA), and vagal efficiency (VE) were analyzed using linear regression and mixed-effects modeling.

RESULTS:
After exclusion of medication confounders, 23 patients with CVS were included in analyses. Both groups were comparable in age, gender, and body mass index. Compared with HC, children with CVS had shorter heart period (standardized mean difference range: 1.15–1.22, all P values < 0.05) and lower RSA (SMD range: 0.66–0.88, all P values < 0.05). Patients with CVS had significantly lower VE during the entire course of posture shifts, compared with HC (B = −19.87, SE = 6.95, t = −2.86, P = 0.005, SMD = 0.76).

DISCUSSION:
Children with CVS have suboptimal parasympathetic autonomic regulation compared with HC, indexed by reduced RSA and VE, even during their interepisodic well phase. Abnormal vagal modulation may underlie CVS pathophysiology, comorbidities, and triggers. Assessing VE during posture stressors could inform therapeutic interventions.