bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knockdown of BMI1 is sensitive to Paclitaxel in cervical and endometrial cancer
Authors: Zhao Yiting , Lin Yan , Yang Weili , Chen Jun , Jin Xiaofeng 
Published: February 2023

Abstract
Background
BMI1, a critical member of the Polycomb Repressor Complex 1, plays a key role in regulating cell proliferation, differentiation, and senescence; however, abnormal expression of BMI1 is associated with the occurrence and progression of tumors, chemotherapeutic resistance, and poor prognosis.
Methods
In this study, we used the TCGA and CPTAC database to analyze the mRNA and protein expression of BMI1 in cervical and endometrial cancer. Next, we analyzed the protein expression level of BMI1 in 40 pairs of human cervical cancer (CC) tissue samples and 12 pairs of endometrial cancer (EC) tissue samples by IHC Analysis. Western blotting and RT‑qPCR were used to detect the changes of mRNA and protein levels in CC and EC cells after BMI1 knockdown. Additionally, the function of BMI1 in CC and EC cancer cells were studied through cell functional experiments. Finally, we assessed the synergic anti-growth effect of shBMI1 combine with paclitaxel (PTX) treatment by assay.
Results
Mining the data from TCGA database, the mRNA level of BMI1 was significantly high in several malignant tumors, but not in CC and EC. However, through the TCGA database, high mRNA levels of BMI1 were associated with the pathological type of CC, and high protein levels of BMI1 were related to the pathological type and tumor grade of EC via the CPTAC database. Furthermore, the BMI1 protein level is overexpressed in cancer tissues of CC and EC compared with normal tissues, as detected by IHC analysis, and the clinical data indicate that the expression of BMI1correlates with the pathological differentiation of the two cancers. Additionally, we showed that high expression of BMI1 in vitro promoted the proliferation and migration of CC and EC cells. Moreover, CC and EC cells with low BMI1 expression were more sensitive to the paclitaxel (PTX).
Conclusions
Our results show that BMI1 is overexpressed in the tumor tissues of CC and EC patients and provides potential information for the treatment of PTX by targeting the oncogenic protein BMI1 in patients with high BMI1 expression.
The Impact of New Space Entails Sustainability on Earth
Authors: Lamboglia Elisabetta , Mogha Vedant , Cambone Giulia 
Published: February 2023

Abstract
New Space is shifting satellites’ value to the actionable services they can deliver, and their potential for change in our approach to space. An agile mission design enhances data accessibility and innovation, adopting lower budgets and shorter schedules.
In this paper we show that New Space entails sustainability for both the upstream and downstream elements of a space mission. We delved into the benefits that such a paradigm shift of space delivers to multi-dimensions of sustainability: economic, socioeconomic, and environmental.
We assess how leaner satellite manufacturing allows the acceleration of design, development, and processes. Involving smaller actors and enlarging the horizons to unprecedented jobs deployment. Furthermore, New Space can reduce the environmental footprint of space activities.
We demonstrate how Earth Observation (EO) data is transformed into added-value insight, and how it tackles the Sustainable Development Goals (SDGs).
Thereby, this article promotes today’s sustainable contribution up to space, thus empowering the next generation to live in a greener future, stemming from space.
Impact of sugars on kidney stone formation
Authors: Bottrill Odin , Graham Alex , Boon Matthew , Mocerino Mauro , Jones Franca 
Published: February 2023

Abstract
Various studies have found a trend connecting diabetes mellitus or carbohydrate malabsorption syndromes to kidney stone formation. However, it is unclear what the underlying mechanism causing this impact is. An important aim of this work was to investigate whether some of this correlation is due to the underlying chemistry of sugars as crystal growth modifiers. Thus, the impact of major dietary monosaccharides (glucose, fructose and galactose) and disaccharides (lactose, sucrose) on the formation of calcium oxalate, a major component of kidney stones, was investigated. Evaluating the impact of monosaccharides on the nucleation of calcium oxalate shows that generally, a promotion in the nucleation rate of particles is seen. Evidence was also obtained of monosaccharides being present within the crystal, showing a close association between the sugars and calcium oxalate. In the case where lactose was present there was also an obvious promotion of nucleation in the solution. This may give context to the observed incidence of stones in lactose-intolerant patients. When sucrose was present as an additive an interaction with both the crystal and the solution ions was observed. This sucrose-ion interaction has been observed previously in literature. There is minimal impact of most sugars on the zeta potential of particles formed. Only the presence of galactose and lactose showed some interaction on zeta potential when zinc ions were also present. The results presented in this work suggests that sugars in urine can promote calcium oxalate formation and agglomeration and as such may suggest a chemical basis, in addition to a biological basis, to the higher prevalence of stones in diabetic patients. This work, therefore, may assist in understanding what the role of dietary sugar malabsorption has on the formation of kidney stones.
Correlation of wood properties with chemical composition and microstructure of wood components
Authors: Cheng Liting , Zhao Peng , Di Yajing , Dai Jian , Wang Wei 
Published: February 2023

Abstract
In order to investigate the nature of the change of wood properties, to understand and master the deterioration mechanism of wood properties, this paper takes the wooden components replaced during the renovation of the Guhuaxuan in the Imperial Palace as the research object, nondestructive testing technology, chemical composition analysis and electron microscope scanning(SEM) analysis were adopted to study the changes of the chemical composition and microstructure of the wooden components, so as to establish the correlation between the macroscopic performance of wood and its chemical composition and microstructure. The results showed that cellulose, hemicellulose and lignin degraded to a certain extent after the wood was used for a period of time under the influence of visible light, temperature and water, and the components and degrees of degradation were different at different locations. The correlation between heterocellulose, α-cellulose, lignin and wood component density and modulus of elasticity (Ed) are good, and the order was α-cellulose > heterocellulose > lignin. The density and crystallinity of wood components are positively correlated with Ed.
Dyslipidemia trends in young adults: a population-based longitudinal study in Xinjiang,China
Authors: Zhi Xiao-Yu , Zheng Ying-Ying , Wang Zhi-Long , Suna Chang-Hao , Yin Xin , Liu Yi-Tian , Wu Ting-Ting , Xie Xiang 
Published: February 2023

Abstract
Aim: To clarify the prevalence of dyslipidemia and trends in changes in lipid profile in young college students.
Methods: This was a retrospective, longitudinal study. A sample of 937 students from Xinjiang Medical University was included. All baseline data and blood lipid tests obtained from 2018 and 2021 physical exams were evaluated. The trends are computed using linear regression.
Results: Compared with 2018, the incidence of dyslipidemia increased significantly in 2021, and the mean values of body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) increased, while the mean values of high-density lipoprotein cholesterol (HDL-C) decreased significantly. In the sub-analysis of sex, ethnicity, and BMI groups, we found that the values of the cardiovascular risk components were higher in males than in females, and that the increase in the prevalence of dyslipidemia over three years was more specific in males than in females. Differences in blood lipid composition across ethnic groups were more pronounced in 2021, with significant increases in the prevalence of low LDL-C and dyslipidemia within the Han, Uygur and Kazak ethnic groups, as well as among lean, normal, overweight and obese groups based on BMI nutritional status. The rate of dyslipidemia increases with BMI. The incidence of high TG, high LDL-C and low HDL-C was significantly higher in the obese group than in the other groups. The results of linear regression revealed that, in total students (R2 =0.315), Sex (β=-1.125, P<0.001), SBP (β=0.034, P=0.002), DBP (β=0.058, P<0.001), TG (β=1.047, P<0.001), HDL (β=-2.474, P<0.001) were the independent risk factors of BMI.
Conclusions: This study demonstrates an increasing trend of dyslipidemia in young adults, which enriches the limited data on early changes in lipid profiles and gives insight into the distress of dyslipidemia in young adults.
Research on the Simulation of Catering Multi-component Gas Transport
Authors: Lu Zhongliang , WEI Xuanxuan , Gao Sudi , Fang Zheng , Guan Yiyao 
Published: February 2023

Abstract
In order to explore the effects of multi-component gases and aerosol emitted by restaurants on the surrounding residents, a low-rise residential building of the certain adjacent dining street in Jiaozuo City was selected as the research object. We regarded the surrounding restaurants that emited soot as a source of pollution. After using solid-works to establish the geometric model, we compared several different computational fluid dynamics models and proposed a multi-component transport model suitable for this situation. Finally, we used ANSYS Icepak software to deal with multi-component gas in the residential building and numerically simulated its distribution. The results of flow field and internal and external pressure distribution were obtained by simulation calculation. Because the airflow field generated eddy currents within it, it not only became the power source of pollutants, but also expanded the pollution area. Besides, for the harmful substances appeared in the same building, the higher concentration that had much more serious impact on the upper dwellers inside of the building distributed at the level. These provided a theoretical basis for mastering the distribution of soot, we can use it to fundamentally reduce the impact of soot emissions on residents' health.
Teachers’ experiences of in-service training on inclusive education: a South African perspective
Authors: Nembambula Tshililo Annah , Ooko Mary , Aluko Ruth 
Published: February 2023

The object of this research: The purpose of this qualitative phenomenological study was to explore and describe teachers’ experiences of in-service training on inclusive education. While diverse literature has dealt with teachers’ experiences of in-service training programmes and the conceptualization of inclusive education, the majority of these studies show limited focus on in-service training programmes tailored according to identified classroom needs.
Methods: This study adopted a phenomenological research design. The purposive and conveniently selected 8 participants enrolled in the BEd Honours (Learning Support) distance education programme participated in the study. Furthermore, the study’s data collection process involved telephonic semi-structured interviews. The study used a thematic data analysis method.
The main scientific results: The findings in this study indicated that the themes of learning barriers and inclusive education training. Moreover, the findings indicated that BEd Honours is informative and necessary for professional development; however, some participants shared concerns about the limited application material in the training programme.
The area of practical use of the research results: This is for teachers in the in-service training. By identifying and uncovering teachers’ needs to implement inclusive education, these findings can be used to improve in-service training programmes
The biological and environmental features of reproduction and distribution of dominant harmful organisms in modern conditions
Authors: Dolia Mykola , Khemelnytskyy Vasyl , Moroz Serhii , Sakhnenko Dmytro , Humeniuk Liudmyla , Mamchur Denys 
Published: February 2023

The article presents research on the features of reproduction of dominant pests of species of organisms in agrobiocenoses growing cereals, leguminous crops, sunflowers and flowers. The article describes the latest ways to control a complex of soil harmful insect species in short-rotation field crop, as well as aerogenic harmful organisms in the integrated use of plant protection products of nutrition systems. In addition, we have identified individual levels of biologically oriented mechanisms of self-regulation of harmful organisms with measures to stabilize the functioning of agrocenoses, which are supplied with natural adaptive reactions in trophic chains.
In the region of observations, the complex of pests is controlled by spiders, nematodes, mites, pathogens, predators and parasites. A variety of causative agents of bacterial, fungal, viral and protozoal diseases of phytophagous insects deserve special attention.
Parasites and predators appear everywhere with trophic chains in 16 rows of the insect class. In recent years, predatory species of ground beetles from a number of Hymenoptera insects that feed on aphids on corn crops with unreasonable intensive use of nitrogen fertilizers have acquired significant importance.
The use of compositions of insecticide + UAN, 32 % for seed treatment of grain crops, allows to save mineral nutrition and get an increase in grain yield up to 27 %. This helps to optimize the state of cenoses and obtain high-quality grain while reducing the cost. Measures have been developed to realize the productivity potential of field crops and flowers through low-cost plant protection measures and to determine the mechanisms for controlling the number of phytophages and the development of dominant types of diseases according to the characteristics of their biology and ecology
Systemic Effects of Peritoneal Instillation of a Polyethylene Polymer Based Obstetrical Lubricant in Cows
Authors: Frazer G. S. , Silviera F. , Anderson D. E. , Beard W. L. , Abrahamsen E. , Premanandan C. , DeBruin A. 
Published: February 2023

Incidence of dystocia in well managed herds has declined due to better selection of bulls that have proven 'calving ease' scores, However, obstetrical complications remain an important reason for veterinary services on many farms, Instillation of copious volumes of obstetrical lubricant is advocated to protect the delicate tissues of the cow's reproductive tract, Another important consideration is the need to distend the uterus such that additional space becomes available in which to manipulate the fetus, If attempts at manipulation are unsuccessful, then an experienced clinician may be able to resolve the problem by fetotomy. However, if a uterine laceration is present, or if a cesarean section becomes necessary, then the lubricant may enter the peritoneal cavity. This is especially likely during a standing flank cesarean section where complete exteriorization of the incised portion of the uterus does not always occur. A common obstetrical lubricant consists of a polyethylene polymer (PEP) in a dispersing agent base that, when mixed with water to the appropriate consistency, forms a 1-2% (w/v) solution. Effects of this PEP-based lubricanton the peritoneal cavity, and potential for toxicity, are not known. Thus, some surgeons express concern about prior use of large volumes of liquid obstetrical lubricant. However, the principal investigator counters that if copious volumes are not used, then far more cows will require surgery.
This project was designed to simulate accidental contamination of the peritoneal cavity during a cesarean section (approx. 1.0 liter), and to determine what effects, if any, a PEP-based lubricant may have on the bovine peritoneal cavity. The hypothesis was that a mild, transient peritonitis would result; that no fibrin deposition would occur; and that no systemic effects would occur. Peritonitis is a serious disease that, if not treated early and actively, can be fatal. The fibrin deposited on damaged or irritated tissues often results in adhesions which can lead to rumenal atony, intestinal blockage and abdominal pain. The proposal entailed serial abdominocentesis followed by euthanasia at two weeks to investigate the possibility of adhesions. The Ohio State University Institutional Laboratory Animal Care and Use Committee (ILACUC) required that a preliminary study be conducted on rodents.
Understanding Bovine Behavior for Safe Handling
Authors: Wagner Sarah 
Published: February 2023

Understanding the behavior of cattle makes working with them easier, safer and more enjoyable. Reading the cow's body language helps indicate if she is relaxed or stressed, healthy or ill. A cow will remain calmer and easier to work with if she can see you approach her. Stress may be minimized by taking care not to isolate a cow away from other cattle and by minimizing startling or loud noises, including yelling. Cows are individuals; like people, some will remain relatively calm and some will become agitated under the same circumstances. Cows that are handled gently tend to be gentler cows than those that are handled roughly.
Keeping the principles of flight zone and point of balance in mind will make moving cattle as quick and calm as possible. When cattle are lined up in a chute or alley, walking through their flight zone in a nose-to-tail direction will cause each animal to step forward as their point of balance is passed.
Cattle may become aggressive when they feel threatened, anxious, or protective of a calf. If a cow shows signs such as vocalization, pacing, pawing, or head-shaking, entering her flight zone may cause her to attack. Bulls must always be handled carefully, particularly dairy breed bulls. A bull that displays a broadside threat should be removed from the herd at once.
Association Between Mycobacterium avium subsp paratuberculosis Fecal Shedding or Clinical Johne's Disease and Lactation Performance on Two Minnesota, USA Dairy Farms
Authors: Raizman Eran A. , Fetrow John , Wells Scott J. , Godden Sandra M. , Oakes Michael J. 
Published: February 2023

The scientific literature provides little information about the impact of Mycobacterium paratuberculosis shedding in dairy cattle on lactation performance, including the attributable reduction of milk production and productive longevity in the herd due to clinical and sub-clinical Johne's disease (JD). It is clear from the literature that JD infected cows are removed from the herd earlier in life than their non-infected herdmates. Many cattle with JD clinical signs are culled due to poor production even before a diagnosis of JD is confirmed, especially common in freestall housing where an individual cow's manure consistency is less obvious than in tiestall housing. Although several studies have considered the effect of JD on culling rate, none have addressed the impact of subclinical JD or fecal shedding level on the survival of the cow in the herd.
Because of its economic importance, the impact of JD on milk production has been the most commonly evaluated effect of JD. Most studies have shown that JD-positive cows produce between 2-17% less milk than their negative herdmates, though the diagnostic test and the definition of positive cows varied between the studies. None of these studies have addressed the potential confounding impact of other factors, such as other clinical diseases, on this relationship.
Few studies have estimated the impact of JD on reproductive performance. These studies have used different diagnostic testing methods, with some defining positive cows based on fecal culture or histology, and others using ELISA results. The lack of consistent associations in these studies may be explained by the variation of results from use of different diagnostic methods.
Managing the Cow at Calving Time
Authors: Mee John F. 
Published: February 2023

Despite increased emphasis in recent years on declining dairy cow reproductive performance, there has been very little focus on the management of the periparturient dairy heifer and cow at calving time. Perhaps as a result, US producers are now reporting increasing perinatal calf losses at calving. A critical determinant in reducing periparturient losses is good calving management. The tenets of good calving management are predicting accurately when calving is due, moving heifers and cows to the maternity unit on time, discrete calving supervision, and critically knowing when and how to intervene during calving. This article deals with each of these topics, outlining where veterinarian-led producer implementation of good calving management can improve perinatal survival and welfare.
The three rules of spring.If it's in, pull it out,If it's out, push it in,And if it's down, give it calcium.--(Irish veterinary aphorism)
Influence of different track structures on the development of corrugation in small radius curve section of subway
Authors: Lei Zhenyu , Zhou Yulong , Li Li 
Published: February 2023

Many studies have shown that the rail corrugation on the small radius curve section of subway floating slab track is serious. And it seems to be different from the rail corrugation on the common track. The track structure must play an important role in the generation and development of rail corrugation. This paper measured a subway line in Tianjin, including 2 different track structures, and analyzed the measured data by using the international evaluation and acceptance indexes of rail corrugation. The results show that the inner rail of short sleeper monolithic track (SSMT) has poor smoothness in the wavelength range of 0-300 mm, and the overall smoothness of outer rail is good; the inner rail of steel spring floating slab track (SSFST) has poor smoothness in the wavelength range of 100-300 mm, and the outer rail has poor smoothness in the wavelength range of 300-1000 mm. Then the vehicle-track coupling model and wheel-rail wear calculation model is established. The calculation results show that in the existing rail corrugation, the short-wavelength rail corrugation of 20-25 mm will continue to appear or deteriorate, and the development of rail corrugation of other wavelengths will slow down or stop to varying degrees; with the increase of train passing times, the rail corrugation of SSFST with the wavelength of 315 mm develops the fastest, and the rail corrugation of SSMT with wavelengths of 20 mm and 160 mm develops the fastest.
The impact of the regularization on the economic analysis of rooftop rainwater harvesting system
Authors: Himat Abobakar , Dogan Selim 
Published: February 2023

Abstract
In this study, the economic feasibility of rooftop rainwater harvesting of residential and public/commercial buildings for all 81 provinces of Türkiye is assessed. The Rippl method (RM) is used for optimal storage tank estimation. The net present value (NPV) and the discounted payback period (DPP) are used for economic analysis. Two scenarios were assessed using RM for (I) residential buildings and (II) public buildings. Optimal storage tanks for scenarios I and II were estimated by the selection of minimum roof areas to supply the demand for toilet flushing water for above 90% volumetric reliability. ArcGIS 10.2 was used to illustrate nationwide results of (1) roof areas and storage tank volumes, and (2) the economic analysis. The average DPP of rainwater harvesting system is 36 years for residential buildings and 23 years for public buildings. Based on NPV analysis, 17 out of 81 provinces are economically feasible for residential buildings. The feasibility status in public buildings is 43 economically feasible and 38 infeasible. More savings in public buildings can be obtained in a relatively shorter DPP. Furthermore, regularization is more effective in public buildings than residential buildings.