bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Imaging Features and Prognosis of Pulmonary Tuberculosis
Complicated with Pulmonary Embolism
Authors: Zhang Yi-Wen , Wu Dan , Zhu Zhen-Zhen , Ou Jin-Chun , Kong Zhuo-Chao , Zhu Wen-Fang , Shi Qing-Ming , Wang Min 
Published: March 2023

Objective:
This study aimed to explore the imaging characteristics of patients with pulmonary tuberculosis complicated with pulmonary embolism and analyze the prognosis of the condition, thereby reducing the mortality and misdiagnosis rate of complications in this type of pulmonary tuberculosis.

Methods:
In this retrospective study, a total of 70 patients diagnosed with pulmonary embolism by computed tomography pulmonary angiography (CTPA)
from January 2016 to May 2021 in Anhui Chest Hospital were included. Among them, 35 patients with pulmonary embolism combined with
pulmonary tuberculosis were set as the study group, and the other 35 patients with pulmonary embolism only were set as the control group. The
imaging findings of chest CT examination, the incidence of pulmonary hypertension, the level of N-terminal proto-B-type brain natriuretic peptide
(NT-proBNP), and the prognosis of patients were compared between the two groups. The incidence of deep venous embolism was evaluated by
ultrasonography of the lower extremity.

Results:
In the study group, the median age of patients was 71 years, and the ratio of males to females was 2.5 to 1. In the control group, the median age was 66 years old, and the male-to-female ratio was 2.2 to 1. There were 16 cases (16/35, 45.71%) in the study group and 10 cases (10/35, 28.57%) in the control group with an increased level of NT-proBNP. Pulmonary hypertension occurred in 10 patients (10/35, 28.57%) in the study group and 7 patients (7/35, 20.00%) in the control group. Patients who lost follow-up included 5 in the study group (5/35, 14.29%) and 3 in the control group (3/35, 8.57%). There were 17 cases (17/35, 48.57%) in the study group and 3 cases (3/35, 8.57%) in the control group with pulmonary artery widening, and the difference was significant (P <.001). There were 13 deaths in the study group (13/35, 37.14%) and 1 death in the control group (1/35, 2.86%), and the difference was significant (P <0.001).

Conclusion:
Special signs of pulmonary artery widening, pulmonary hypertension of varying degrees, and increased levels of NT-proBNP of varying degrees can be found in patients with pulmonary tuberculosis complicated with pulmonary embolism, and the three signs are positively correlated. The mortality of patients with pulmonary tuberculosis complicated with pulmonary embolism is significantly higher than that of patients with pulmonary embolism alone. Pulmonary tuberculosis and pulmonary embolism both occur in the ipsilateral lung, causing clinical symptoms to cover each other, thereby making diagnosis difficult.
Formulation of Thiamine-Laden Chitosan Nanosphere for Nutraceutical
Application
Authors: Kaur Harsimran , Kaur Mandeep , Rajesh Preeti , Kaur Harsimrat 
Published: March 2023

Introduction::
Thiamine, often known as vitamin B1, is a water-soluble vitamin that
can be added to food or purchased as a supplement. It plays an important role in many cellular
processes and is crucial for overall human health. The synthesis and characterization of Thiamineencapsulated
chitosan nanospheres for sustained release and improved bioavailability is the major
objective of this study.

Materials and Methods:
The chitosan nanospheres were prepared using sodium tripolyphosphate
(TPP) as cross-linking agent.

Results::
The ionic interactions between chitosan and TPP produced small-sized stable
nanospheres for the incorporation of Thiamine. The conjugate was characterized through a UV
spectrophotometer and Fourier Transform Infrared spectroscopy (FTIR). The size and morphology
were determined using Zetasizer and Scanning Electron Microscopy (SEM). An average size of 504
nm size was obtained for the nanospheres. The in vitro release studies were performed for 30 days
to assess the sustained release of thiamine from nanoencapsulates. Cellular uptake of the
thiamine-encapsulated chitosan nanoparticles was studied in the human cervical cancer cell lines
(HeLa) and mus-musculus 3T3 L1 cell lines.

Conclusion::
This study is an early design and development of a technology for encapsulating
water-soluble vitamins in biodegradable polymers, which can be examined for the vitamin's
long-term bioavailability.
Eupatorin from Orthosiphon aristatus: A Review of The Botanical Origin,
Pharmacological Effects and Isolation Methods
Authors: Chriscensia Erika , Aqila Arham Alya , Chrestella Wibowo Elizabeth , Gracius Lavisiony , Nathanael Joshua , Hartrianti Pietradewi 
Published: March 2023

Abstract:
Orthosiphon aristatus has been known for its medicinal uses. One of the compounds
responsible for the pharmacological activities of O. aristatus is a flavonoid called Eupatorin (EUP).
EUP has been studied for its pharmacological activities, including anti-inflammatory, vasodilating,
antiproliferative, hepatoprotective, analgesic, and antidiabetic properties. Despite its importance
and abundance, currently, there is no published paper that reviews the characteristics, pharmacological
activities and isolation methods of EUP. This review summarizes the botanical origin, phytochemical
characteristics, pharmacological activities, isolation, as well as identification and characterization
methods of EUP from O. aristatus. This paper also compares different isolation methods
based on the parameters and the resulting yields. Various isolation methods had been used to obtain
EUP. Reverse-phase high-performance liquid chromatography (HPLC) is the most commonly used
method to isolate EUP, followed by preparative thin layer chromatography (TLC) and crystallization
for the purification. Various spectroscopic methods, including UV-Vis, FT-IR, Mass, and
NMR spectroscopy have been commonly used to identify and characterize EUP. This paper
provides a comprehensive insight into EUP from O. aristatus which might be beneficial for future
research using this compound.
Evaluation of BMP-2 as a Differentiating and Radiosensitizing Agent for
Colorectal Cancer Stem Cells
Authors: Mahmoudi Roghayeh , Afshar Saeid , Amini Razieh , Jalali Akram , Saidijam Massoud , Najafi Rezvan 
Published: March 2023

Background:
Despite effective clinical responses, a large proportion of patients undergo resistance
to radiotherapy. The low response rate to current treatments in different stages of colorectal cancer
depends on the prominent role of stem cells in cancer.

Objective:
In the present study, the role of BMP-2 as an ionizing radiation-sensitive factor in colorectal
cancer cells was investigated.

Methods:
A sphere formation assay was used for the enrichment of HCT-116 cancer stem cells (CSCs).
The effects of combination therapy (BMP-2+ radiation) on DNA damage response (DDR), proliferation,
and apoptosis were evaluated in HCT-116 and CSCs. Gene expressions of CSCs and epithelialmesenchymal
transition (EMT) markers were also evaluated.

Results:
We found that the sphere formation assay showed a significant increase in the percentage of
CSCs. Moreover, expression of CSCs markers, EMT-related genes, and DNA repair proteins significantly
decreased in HCT-116 cells compared to the CSCs group after radiation. In addition, BMP-2 promoted
the radiosensitivity of HCT-116 cells by decreasing the survival rate of the treated cells at 2, 4, and 6 Gy
compared to the control group in HCT-116 cells.

Conclusion:
Our findings indicated that BMP-2 could affect numerous signaling pathways involved in
radioresistance. Therefore, BMP-2 can be considered an appealing therapeutic target for the treatment of
radioresistant human colorectal cancer.
Feasibility and Acceptability of a US National Telemedicine Curriculum for Medical Students and Residents: Multi-institutional Cross-sectional Study
Authors: Bajra Rika , Frazier Winfred , Graves Lisa , Jacobson Katherine , Rodriguez Andres , Theobald Mary , Lin Steven 
Published: March 2023

Background
Telemedicine use increased as a response to health care delivery changes necessitated by the COVID-19 pandemic. However, lack of standardized curricular content creates gaps and inconsistencies in effectively integrating telemedicine training at both the undergraduate medical education and graduate medical education levels.

Objective
This study evaluated the feasibility and acceptability of a web-based national telemedicine curriculum developed by the Society of Teachers of Family Medicine for medical students and family medicine (FM) residents. Based on the Association of American Medical Colleges telehealth competencies, the asynchronous curriculum featured 5 self-paced modules; covered topics include evidence-based telehealth uses, best practices in communication and remote physical examinations, technology requirements and documentation, access and equity in telehealth delivery, and the promise and potential perils of emerging technologies.

Methods
A total of 17 medical schools and 17 FM residency programs implemented the curriculum between September 1 and December 31, 2021. Participating sites represented 25 states in all 4 US census regions with balanced urban, suburban, and rural settings. A total of 1203 learners, including 844 (70%) medical students and 359 (30%) FM residents, participated. Outcomes were measured through self-reported 5-point Likert scale responses.

Results
A total of 92% (1101/1203) of learners completed the entire curriculum. Across the modules, 78% (SD 3%) of participants agreed or strongly agreed that they gained new knowledge, skills, or attitudes that will help them in their training or career; 87% (SD 4%) reported that the information presented was at the right level for them; 80% (SD 2%) reported that the structure of the modules was effective; and 78% (SD 3%) agreed or strongly agreed that they were satisfied. Overall experience using the national telemedicine curriculum did not differ significantly between medical students and FM residents on binary analysis. No consistent statistically significant relationships were found between participants’ responses and their institution’s geographic region, setting, or previous experience with a telemedicine curriculum.

Conclusions
Both undergraduate medical education and graduate medical education learners, represented by diverse geographic regions and institutions, indicated that the curriculum was broadly acceptable and effective.
Roles and Competencies of Doctors in Artificial Intelligence Implementation: Qualitative Analysis Through Physician Interviews
Authors: Tanaka Masashi , Matsumura Shinji , Bito Seiji 
Published: March 2023

Background
Artificial intelligence (AI) is a term used to describe the use of computers and technology to emulate human intelligence mechanisms. Although AI is known to affect health services, the impact of information provided by AI on the patient-physician relationship in actual practice is unclear.

Objective
The purpose of this study is to investigate the effect of introducing AI functions into the medical field on the role of the physician or physician-patient relationship, as well as potential concerns in the AI era.

Methods
We conducted focus group interviews in Tokyo’s suburbs with physicians recruited through snowball sampling. The interviews were conducted in accordance with the questions listed in the interview guide. A verbatim transcript recording of all interviews was qualitatively analyzed using content analysis by all authors. Similarly, extracted code was grouped into subcategories, categories, and then core categories. We continued interviewing, analyzing, and discussing until we reached data saturation. In addition, we shared the results with all interviewees and confirmed the content to ensure the credibility of the analysis results.

Results
A total of 9 participants who belonged to various clinical departments in the 3 groups were interviewed. The same interviewers conducted the interview as the moderator each time. The average group interview time for the 3 groups was 102 minutes. Content saturation and theme development were achieved with the 3 groups. We identified three core categories: (1) functions expected to be replaced by AI, (2) functions still expected of human physicians, and (3) concerns about the medical field in the AI era. We also summarized the roles of physicians and patients, as well as the changes in the clinical environment in the age of AI. Some of the current functions of the physician were primarily replaced by AI functions, while others were inherited as the functions of the physician. In addition, “functions extended by AI” obtained by processing massive amounts of data will emerge, and a new role for physicians will be created to deal with them. Accordingly, the importance of physician functions, such as responsibility and commitment based on values, will increase, which will simultaneously increase the expectations of the patients that physicians will perform these functions.

Conclusions
We presented our findings on how the medical processes of physicians and patients will change as AI technology is fully implemented. Promoting interdisciplinary discussions on how to overcome the challenges is essential, referring to the discussions being conducted in other fields.
Diversity of <i>Fusarium</i> Endophytes Isolated from Wild Bananas in Pandenglang, Indonesia
Authors: Maryani Nani , Yulianti Siti , Ramadhani Indriati , Khastini Rida Oktorida , Leksono Suroso Mukti 
Published: March 2023

A group of Fusarium spp., in the Fusarium oxysporum species complex is known as pathogens on bananas, i.e., Fusarium wilt or Panama Disease. However, many Fusarium spp. are also known to be endophytes inside healthy banana plants and have been less explored and investigated. Fusarium endophytes have been demonstrated to be effective against the Fusarium pathogen that causes wilting in some crops such as tomatoes and watermelon. Thus, we explored endophytes Fusarium from local bananas in Pandenglang Banten for further use as biocontrol of Fusarium wilt. Four wild banana accessions were identified, from which 9 Fusarium isolates recovered from its pseudostems asymptomatic plants. All isolates were characterized based on their morphological characters and sequence of the Internal Transcribed Spacer (ITS) gene. These isolates belong to four complexes of Fusarium i.e. Fusarium equiseti species complex, Fusarium oxysporum species complex, Fusarium sambucinum species complex, and Fusarium solani species complex (currently described as Neocosmospora). Further study on molecular characterization of these isolates using specific genes and their potential antagonists of pathogens still needs to be discovered for other use as a biocontrol against Fusarium wilt.
ОДНОС НАСТАВНИКА ПРЕМА ИНОВИРАЊУ НАСТАВНЕ ПРАКСЕ: ПРОЦЕНЕ ИСТРАЖИВАЧА
Authors: Malinić Dušica , Đerić Ivana , Šefer Jasmina 
Published: March 2023

The evaluations by researchers monitoring attitudes towards innovations among teacher groups were analyzed during the process of implementing innovations in one elementary school. The teachersʼ attitudes towards innovative practice were evaluated from the following perspectives: (1) motivation of teacher groups to grasp and implement knowledge and skills acquired during the intervention, (2) improvement of teacher groups in the area of knowledge and skills, (3) the role of researchers in enhancing motivation of teacher groups to change their practice, (4) the role of the teacher groups in motivating individuals to change practices (while working on professional issues). Sixteen researchers/evaluators followed up six teacher groups during the intervention. The researchers had a double role. They were educators on the teacher training course and facilitators in the teacher working groups. A method of structured guided interviews was applied in the case follow up study. Quantitative and qualitative data were analyzed. The results show that the teacher groups manifested а moderate motivation in each of the following areas: implementing student group work, open ended tasks, creative play, student research activities and critical dialogue in class. After training, teacher skills in implementing the previously mentioned types of activities in class were significantly improved in all areas, but the greatest improvement was in the most unfamiliar area of open-ended tasks. The influence of the researches on the teacher groupsʼ motivation appears to be stronger than the influence of teacher groups on individuals. Suggestions were listed relating to the innovative process in class, from the perspectives of researchers/evaluators.
Portrait of psychological well-being in individuals who have coming out as gender dysphoria
Authors: Kuway Hana Gracya , Huwae Arthur 
Published: March 2023

Choosing to be a gender dysphoria is quite difficult to voice yourself in behavior, expression, even in dress, good and bad responses always come. In Indonesia, it is still fairly sensitive to talk about gender deviation. Individuals who have been diagnosed as gender dysphoria by psychologists / psychiatrists could propably feel unconfortable in society. Some of them who have come out in the environment but have not been fulfilled in terms of psychological well-being due to several factors. Based on the phenomenon that occurs, researchers want to examine the portrait of psychological well-being, both through dimensions and factors in individuals who have come out as gender dysphoria. The method used in this study is qualitative descriptive phenomenology. The data collection process is carried out by using observations, interviews, and documents. Data analysis is performed using interactive data analysis methods. The results of this study show that in general gender dysphoria individuals who have come out have been fulfilled in the picture of psychological well-being for themselves and the surrounding environment, where it appears that participants have fulfilled the dimensions and factors of psychological well-being theory of Ryff and Keyes (1995). Researchers also found a new factor that affects psychological well-being, namely the self-love factor.
Long Noncoding RNA lncRHPL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis
Authors: SHEN Xuan , ZHANG Yajun , JI Xuetao , LI Bo , WANG Yuzhu , Huang Yun , ZHANG Xu , YU Jingxian , ZOU Ruihan , QIN Dongdong , ZHOU Hongwen , WANG Qian , LI John Zhong 
Published: March 2023

<p>Dysregulation of hepatic very low-density lipoprotein (VLDL) secretion contributes to the pathogenesis of metabolic diseases, such as Non-alcoholic fatty liver disease (NAFLD) and hyperlipidemia. Accumulating evidence have suggested that long non-coding RNAs (lncRNAs) had malfunctioning roles in the pathogenesis of NAFLD. However, the function of lncRNAs in controlling hepatic VLDL secretion remains largely unillustrated. Here, we identified a novel long non-coding RNA, lncRHPL, which was liver-enriched, downregulated upon high fat diet feeding, and inhibited by oleic acid treatment in primary hepatocytes. With genetic manipulation in mice and primary hepatocytes, depletion of lncRHPL induces hepatic VLDL secretion accompanied with decreased hepatic lipid contents. Conversely, lncRHPL restoration reduces VLDL secretion with an increased lipid deposition in hepatocytes. Mechanistic analyses indicate that lncRHPL binds directly to heterogeneous nuclear ribonuclear protein U (hnRNPU), thereby enhances its stability, and that hnRNPU can transcriptional activate Bmal1, leading to inhibition of VLDL secretion in hepatocytes. lncRHPL deficiency accelerates the protein degradation of hnRNPU and suppresses the transcription of Bmal1, which in turn activates VLDL secretion in hepatocytes. Taken together, lncRHPL is a novel suppressor of hepatic VLDL secretion. Activating the lncRHPL/hnRNPU/Bmal1/MTTP axis represent a potential strategy for the maintenance of intrahepatic and plasma lipid homeostasis. </p>
The AliveCor KardiaMobile ECG device allows electrocardiogram assessment in awake bonobos (Pan paniscus)
Authors: Olds June E. , Goldacker Ashley , Huneycutt David , Huneycutt Sarah P. , Taglialatela Jared P. , Ward Jessica L. 
Published: March 2023

Abstract

OBJECTIVE
To determine the diagnostic utility of a smartphone-based ECG device (Alivecor KardiaMobile) in awake bonobos (Pan paniscus).

ANIMALS
7 adult bonobos in human care.

PROCEDURES
Bonobos were trained with positive reinforcement to hold 1 finger from each hand onto the KardiaMobile sensors for 30 seconds to obtain an ECG reading. Ten ECG tracings were recorded from each bonobo and evaluated by a veterinarian, a veterinary cardiologist, and a human cardiologist for tracing quality, tracing length, heart rate, identification of P-waves, and presence and quantification of premature ventricular or atrial contractions.

RESULTS
6 of the 7 bonobos were trained within 21 weeks to allow the collection of 10 diagnostic quality ECG tracings. The average heart rate recorded was 87 bpm (range = 60 to 118 bpm). Potential abnormalities identified by the KardiaMobile included premature ventricular contractions in 2 male bonobos and 1 premature atrial contraction in another male. There was strong agreement by reviewers in all ECG parameters except for the identification of P-waves.

CLINICAL RELEVANCE
The Alivecor KardiaMobile device has diagnostic utility as a screening tool for use in bonobos in human care. The training was accomplished to yield diagnostic ECG readings of acceptable duration in awake bonobos. Given the prevalence of cardiovascular disease in great apes, this technology may identify a subset of great apes who may benefit from early intervention and treatment in an effort to delay the progression of cardiac disease.
Market Analysis of Drones for Civil Use
Authors: Höhrová Paula , Soviar Jakub , Sroka Włodzimierz 
Published: March 2023

Abstract
This paper deals with the topic of market analysis of drones (or UAVs) for civil use. This is an analytical overview study. In the introduction, we offer an overview of the main historical milestones on the topic of drones. We then provide a classification and explanation of the main types of drones. The main part of the article contains structured information about the drone market, its status in terms of market shares and relative market shares. For a structured view of this market, we used the BCG method: we calculated the market growth and relative market shares. This market is dynamic and growing gradually. Established brands forming a strong competitive environment. In the photo-video segment, the Chinese brand DJI has a strong and dominant position. Demand on the consumer side is also growing, as is the reputation of the most used product brands.