bluuebunny/crossref_metadata_2025_split huggingface dataset:
The informativeness of the top holdings of Chinese equity mutual funds
Authors: Yao Shuyi , Zhang Jianing 
Published: December 2022

PurposeThis study aims to determine whether the stock holdings of equity mutual funds are informative for predicting future stock performance in the Chinese market. It is a puzzle that actively managed mutual funds underperform passive benchmarks, whereas retail investors still delegate investment decisions to the fund managers. The present study sheds light on whether mutual fund managers possess security selection skills in their top ten holdings.Design/methodology/approachBy regression analysis and portfolio sorting, this study focuses on 830 Chinese A-share stocks in the industry research reports from the Guotai Junan Securities Company. It collects mutual fund's top ten holdings data from the Wind Financial Terminal between 2019Q1 and 2021Q1. As robustness checks, the result holds for the fixed-effect model, an additional measure of ranks in the top ten holdings, the predictability test based on the confusion matrix and two stage least square (2SLS) regression.FindingsThe authors find that the top ten holdings by equity mutual funds are informative for predicting stock performance and can provide valuable information for investors to support their decision-making.Practical implicationsThe findings of this study provide insightful guidance for retail investors in making investment decisions and support the hypothesis that active fund management adds value.Originality/valueFirstly, the authors find that the top ten holdings of Chinese mutual funds show significantly positive signals for future stock excess returns, indicating the selection skills of fund managers. Secondly, the above positive relationship exhibits a diminishing marginal effect with more funds holding this stock. Thirdly, the authors find that the predictability horizon of the number of overweighing funds is up to three quarters and then diminishes in the fourth quarter. Finally, investors have a 59% prediction accuracy for the whole stock sample and an 85% precision conditional on the predicted positive subsample to outperform the market. The authors also address the endogeneity and reverse causality issues.
Erythema multiforme associated with cancer radiotherapy: A single‐institution case series and literature review
Authors: Tanaka Nanako , Nakatani Shoko , Yahiro Chisato , Takai Toshihiro 
Published: December 2022

AbstractRadiation dermatitis, limited to the irradiated site, is the most common cutaneous adverse reaction due to radiotherapy. There are scattered reports of erythema multiforme‐like rash, Stevens–Johnson syndrome, and toxic epidermal necrolysis associated with radiotherapy. Some of these reports include cases without remarkable drug history, which suggests rashes induced by radiotherapy. The lack of a large cohort study, however, makes it difficult to ascertain the time course, severity, and outcome of the cases. We aimed to evaluate the potential association between radiotherapy and erythema multiforme‐like rash in a larger sample of patients. We examined the records of patients at our institute who received radiotherapy and developed a rash from 2010 to 2021. We present 30 patients with erythema multiforme‐like rash, which arose during or after radiotherapy. We describe the background, details of radiotherapy, and clinical course of the patients including the cutaneous and extracutaneous symptoms. Radiotherapy was the most likely cause of rash, and in most cases, the rash was relieved by conservative management and radiation could be continued. When erythema multiforme‐like rash arises in patients under cancer treatment, radiotherapy should be considered a potential trigger.
The development of lipoprotein apheresis in Saxony in the last years
Authors: Kuss Solveig Frieda Rosa , Schatz Ulrike , Tselmin Sergey , Fischer Sabine , Julius Ulrich 
Published: December 2022

AbstractMethodsThree hundred thirty‐nine patients (230 men, 109 women) treated with lipoprotein apheresis in Saxony, Germany, in 2018 are described in terms of age, lipid pattern, risk factors, cardiovascular events, medication, and number of new admissions since 2014, and the data are compared with figures from 2010 to 2013.ResultsPatients were treated by 45.5 physicians in 16 lipoprotein apheresis centers. With about 10 patients per 100 000 inhabitants, the number of patients treated with lipoprotein apheresis in Saxony is twice as high as in Germany as a whole. The median treatment time was 3 years. Almost all patients had hypertension; type 2 diabetes mellitus was seen significantly more often in patients with low Lipoprotein(a). Cardiovascular events occurred in almost all patients before initiation of lipoprotein apheresis, under apheresis therapy the cardiovascular events rate was very low in this high‐risk group. For some cardiovascular regions even no events could be observed.ConclusionsThe importance of lipoprotein apheresis in Saxony had been increasing from 2010 to 2018.
Multiple joint dislocations and bone disintegration in rheumatoid arthritis: A case report
Authors: Yuan Xuemei , Luo Feng , Li Chunxiang , Hong Xiong , Ma WuKai , Yao Xueming 
Published: December 2022

AbstractRheumatoid arthritis (RA) is a chronic inflammatory disease, which typically affects the small joints of the hands and feet. Anti‐rheumatism drugs should be promptly administered upon a diagnosis. Without standardized treatment, patients are prone to different degrees of deformities in the later stages of disease development, which negatively impact quality of life. We here report a case of a 52‐year‐old woman with an 18‐year history of RA. After intermittent immunotherapy with anti‐rheumatism drugs, the patient presented with multiple joint pain, dislocation, and disintegration of the bone. The interphalangeal joints of both hands were deformed to varying degrees and movement was significantly limited. After anti‐rheumatism treatment, the patient experienced reduced joint pain. This case should enhance understanding and serve as a guide for patient management toward the prevention of joint deformities caused by RA.
Fourteen‐year trends in the prescribing patterns of pediatric bipolar patients discharged from two public mental hospitals in Taiwan
Authors: Lin Ching‐Hua , Chan Hung‐Yu , Lin Hsin‐Yi , Chen Cheng‐Chung 
Published: December 2022

AbstractIntroductionThe management of pediatric bipolar disorder (PBD) requires pharmacotherapy to control acute symptoms, reduce relapse, prevent suicide, and improve psychosocial functioning. The purpose of this study was to investigate prescribing patterns among PBD patients discharged from two public mental hospitals in Taiwan, from 2006 to 2019.MethodsPBD patients discharged from the two study hospitals, from 1 January 2006 to 31 December 2019 (n = 420), were included in the analysis. Prescribed drugs at discharge, including mood stabilizers (i.e., lithium, valproate, carbamazepine, and lamotrigine), antipsychotics (i.e., second‐ and first‐generation antipsychotics, SGAs and FGAs), and antidepressants, were explored. Complex polypharmacy was defined as the use of 3 or more agents among the prescribed drugs. Time trends of each prescribing pattern were analyzed using the Cochran‐Armitage Trend test.ResultsThe most commonly prescribed psychotropic agents were SGAs (76.0%), followed by valproate (65.7%) and FGAs (24.8%). The prescription rates of SGAs, antidepressants, antidepressant plus antipsychotic, and antidepressant without mood stabilizer significantly increased over time, whereas the prescription rates of mood stabilizers, lithium, and FGAs significantly decreased.DiscussionsPrescribing patterns changed greatly for PBD patients over time. However, much more evidence supporting the effectiveness of psychotropic agents in PBD patients is required.
Bortezomib inhibits hepatocellular carcinoma via the Hippo‐Yes‐associated protein signalling pathway
Authors: Liao Yu , Hu Kejun , Liu Wangwang , Wang Wei , Qiu Huanhuan , Pan Shumin , Lv Qi , Xu Guanglin 
Published: December 2022

AbstractHepatocellular carcinoma (HCC) is one of the principle causes of cancer‐associated death throughout the world. However, the patients with HCC are insensitive to traditional drugs and lack effective therapeutic drugs. Dysregulation of Hippo‐Yes‐associated protein (YAP) signalling is closely associated with HCC. Bortezomib (BTZ) is mainly used in clinical multiple myeloma. It has recently been confirmed that BTZ could suppress cell proliferation in many different types of cancer. Nevertheless, the precise effects of BTZ on HCC and its possible interactions with the Hippo‐YAP signalling pathway in HCC cells remain largely unknown. In this study, HCC cell lines (HepG2 and Huh7) and nude mice with xenograft tumours were used to evaluate the influences of BTZ. Furthermore, we focused on exploring whether BTZ exerts its anti‐HCC effect through the Hippo‐YAP signalling pathway and aimed to lay a theoretical foundation for BTZ as a potential therapeutic drug for HCC. Herein, our results disclose a new mechanism of BTZ in controlling the cell growth of HCC. BTZ downregulates the level of YAP by promoting LATS1 expression to inhibit the growth of HCC cells, which leads to the phosphorylation of YAP and limits YAP nuclear translocation. In sum, our data confirmed that the Hippo‐YAP signalling pathway mediates the anti‐HCC effects of BTZ.
Canada's GBA+ framework in a (post)pandemic world: Issues, tensions and paths forward
Authors: Cameron Anna I. , Tedds Lindsay M. 
Published: December 2022

AbstractThis article traces the theoretical foundations, evolution, and limitations of Gender‐Based Analysis Plus (GBA+), which is the Government of Canada's primary framework for attending to diversity and inclusion in public policy. We argue that GBA+ is, in its current form, inadequate to guide ambitious and transformative policy in the post‐pandemic years given four interlocking issues: (1) a weak integration of intersectionality; (2) insufficient attention to the power structures and socio‐political context undergirding social relations and policymaking; (3) an instrumental understanding of policy; and (4) a misreading of identity. Drawing on feminist, intersectional and post‐structuralist methods, we adjust the GBA+ framework with the aim of addressing the conceptual shortcomings identified in our analysis. Ultimately, we demonstrate how a more explicit engagement with notions of intersectionality, power and policy's instrumental and productive aspects can enrich the ways we think about public policy as both a mechanism and a venue for transformative change.
Outpatient parotidectomy with or without the use of a post‐operative drain: A retrospective bi‐institutional study
Authors: Reerds Sam T. H. , Hey Shi Ying , van den Hoogen Frank J. A. , Takes Robert P. , Ganesh Vaishnevy , Marres Henri A. M. , Manickavasagam Jaiganesh , Honings Jimmie 
Published: December 2022

AbstractObjectiveParotid surgery is historically performed as an inpatient procedure and suctions drains are predominantly used during surgery. Recent literature provides evidence that outpatient parotid surgery is safe and effective. Our study aims to describe the results of drainless outpatient parotidectomy and outpatient parotidectomy with drain placement and compare their outcomes.DesignRetrospective cohort study.SettingBi‐institutional retrospective cohort study.ParticipantsPatients that underwent outpatient drain‐less parotidectomy and patients that underwent outpatient parotidectomy with post‐operative drain placement.Main Outcome MeasuresComplication rates, unplanned post‐operative visits, unplanned prolonged stay.ResultsThree hundred eighty patients underwent outpatient parotidectomy with drain placement and 31 patients underwent outpatient drainless parotidectomy in two different hospitals. The incidence of haematoma (drain: 3.1% vs. drainless: 0%, p = 1), infection (drain: 14.3% vs. drainless: 13.8%, p = 1) and salivary fistula (drain: 5.6% vs. drainless: 3.4, p = 1) were comparable between both groups. Seroma or sialocele was more frequently seen in the drain‐less group (27.6% vs. 6.2%, p < .001), but were all managed conservatively. Within 10 days after surgery, unplanned visits seemed more frequent in the drain group, although the difference was not statistically significant (14.9% vs. 3.4%, p = .16).ConclusionsOutpatient parotid surgery with or without the use of a post‐operative drain is safe, practical and feasible. Same‐day discharge with and without drain placement yield comparable outcomes. However, the results need to be interpreted cautiously as this study was limited by a small cohort of parotidectomies without drain placement. Future studies should further compare both approaches.
CGM accuracy: Contrasting CE marking with the governmental controls of the USA (FDA) and Australia (TGA): A narrative review
Authors: Pemberton John S , Wilmot Emma G , Barnard‐Kelly Katharine , Leelarathna Lalantha , Oliver Nick , Randell Tabitha , Taplin Craig E , Choudhary Pratik , Adolfsson Peter 
Published: December 2022

AbstractThe National Institute for Clinical Excellence updated guidance for continuous glucose monitoring (CGM) in 2022, recommending that CGM be available to all people living with type 1 diabetes. Manufacturers can trade in the UK with Conformité Européenne (CE) marking without an initial national assessment. The regulatory process for CGM CE marking, in contrast to the Food and Drug Administration (FDA) and Australian Therapeutic Goods Administration (TGA) process, is described. Manufacturers operating in the UK provided clinical accuracy studies submitted for CE marking. Critical appraisal of the studies shows several CGM devices have CE marking for wide‐ranging indications beyond available data, unlike FDA and TGA approval. The FDA and TGA use tighter controls, requiring comprehensive product‐specific clinical data evaluation. In 2018, the FDA published the integrated CGM (iCGM) criteria permitting interoperability. Applying the iCGM criteria to clinical data provided by manufacturers trading in the UK identified several study protocols that minimized glucose variability, thereby improving CGM accuracy on all metrics. These results do not translate into real‐life performance. Furthermore, for many CGM devices available in the UK, accuracy reported in the hypoglycaemic range is below iCGM standards, or measurement is absent. We offer a framework to evaluate CGM accuracy studies critically. The review concludes that FDA‐ and TGA‐approved indications match the available clinical data, whereas CE marking indications can have discrepancies. The UK can bolster regulation with UK Conformity Assessed marking from January 2025. However, balanced regulation is needed to ensure innovation and timely technological access are not hindered.
The putative maintaining mechanism of gut bacterial ecosystem in giant pandas and its potential application in conservation
Authors: Cui Xinyuan , Zhang Qinrong , Zhang Qunde , Chen Hua , Liu Guoqi , Zhu Lifeng 
Published: December 2022

AbstractAnimals living in captivity and the wild show differences in the internal structure of their gut microbiomes. Here, we performed a meta‐analysis of the microbial data of about 494 fecal samples obtained from giant pandas (captive and wild giant pandas). Our results show that the modular structures and topological features of the captive giant panda gut microbiome differ from those of the wild populations. The co‐occurrence network of wild giant pandas also contained more nodes and edges, indicating a higher complexity and stability compared to that of captive giant pandas. Keystone species analysis revealed the differences between geographically different wild populations, indicating the potential effect of geography on the internal modular structure. When combining all the giant panda samples for module analysis, we found that the abundant taxa (e.g., belonged to Flavobacterium, Herbaspirillum, and Escherichia‐Shigella) usually acted as module hubs to stabilize the modular structure, while the rare taxa usually acted as connectors of different modules. We conclude that abundant and rare taxa play different roles in the gut bacterial ecosystem. The conservation of some key bacterial species is essential for promoting the development of the gut microbiome in pandas. The living environment of the giant pandas can influence the internal structure, topological features, and strength of interrelationships in the gut microbiome. This study provides new insights into the conservation and management of giant panda populations.
Ethical, legal, organizational and social issues related to the use of scalp cooling for the prevention of chemotherapy‐induced alopecia: A systematic review
Authors: Delgado Rodríguez Janet , Ramos‐García Vanesa , Infante‐Ventura Diego , Suarez‐Herrera José Carlos , Rueda‐Domínguez Antonio , Serrano‐Aguilar Pedro , del Mar Trujillo‐Martín María 
Published: December 2022

AbstractIntroductionScalp cooling (SC) aims to prevent chemotherapy‐induced alopecia. The goal of this systematic review is to tackle ethical, legal, organizational and social issues related to SC.MethodsA critical appraisal of the literature was carried out using a systematic review design. MEDLINE, Embase and Web of Science databases were searched up until 2 June 2021. Studies addressing these aspects in English or Spanish were considered. Representatives of both patient associations and professional scientific societies related to the topic participated in the design of the protocol and the review of the findings.ResultsA total of 17 studies were included. Articles were critically appraised using the MMAT and SANRA. Findings were organized into four categories: (1) ethical aspects focused on equal access, gender equity and doctor–patient communication supported by Patient Decision Aids (PtDAs); (2) patient perspective and acceptability; (3) professional perspective and acceptability; (4) organizational aspects focused on accessibility and feasibility.ConclusionCancer patients' expectations when using SC need to be adjusted to reduce the potential distress associated with hair loss. PtDAs could help patients clarify their values and preferences regarding SC. Equal access to technology should be guaranteed.Patient or Public ContributionIn this systematic review, the representatives of the patient associations (Ms. María Luz Amador Muñoz of the Spanish Association Against Cancer [AECC] and Ms. Catiana Martinez Cánovas of the Spanish Breast Cancer Federation [FECMA]) participated in the review of the study protocol, as well as in the results, discussion and conclusions, making their contributions. In the type of design of these studies (systematic reviews), it is not usual to have the direct participation of patients, but in this one, we have done so, as it is a systematic review that is part of a report of the Spanish Network of Health Technology Assessment Agencies (ETS).
Setting an exam as an information design problem
Authors: Shimoji Makoto 
Published: December 2022

AbstractWe take a teacher's exam‐setting task as an information design problem. Specifically, the teacher chooses a conditional distribution of grades given students' types. After observing their exam results, each student updates her belief regarding her type via Bayes' rule and chooses an action. Students' reactions to the same exam result could be different, depending on their heterogeneous prior beliefs. The teacher's objective is to persuade students to take a certain action (e.g., applying to universities), which some may not choose without an exam. The teacher adopts different grade distributions, depending on the teacher's and the students' heterogeneous prior beliefs.
Relaxing Design Students’ Sketch Inhibition: Experiences with Theoretical Grounding and Impermanent Media
Authors: Altenburger Elke , Falche Isabella , Gwin Haley 
Published: December 2022

AbstractThis article reports about a study developed to understand the effectiveness of instructional strategies to manage sketch inhibition in design students through studio‐based pedagogy. Sketch inhibition among students and recent graduates of design programs is a prominent aspect of the prevailing digitization of the design industry and education. While traditional and digital media are ideally complementary tools to facilitate the complex process of designing, studio instructors struggle to effectively integrate both into their students’ conceptions and practices. Primary data sources were ethnographic fieldnotes, semi‐structured interviews, and students’ responses to open‐ended survey questions. Whiteboards used as an impermanent medium, requests for quantity of sketches, and gentle enforcement of time limits were incorporated into studio practices on the foundation of theoretical grounding. Students understood the purpose and advantages of using hand sketches at strategic moments during the design process. Inhibited students responded to this combination of interventions by relaxing enough to focus on engaging with the relevant design tasks rather than focusing on how best to avoid them. Production of rich records, documenting their projects’ progression, served as supporting evidence that sketching had become a more normal and accepted part of the design process than for previous studio cohorts. The authors suggest more experimentation with these strategies and propose that sketching instructors prioritize and nurture ‘thinking sketches’ over ‘persuasive sketches’ to transfer attention from the representation of design solutions toward the design process and the development of mature design solutions.
Association of occupational noise exposure with hypertension: A cross‐sectional study
Authors: Wang Jin , Zhang Panpan , Wang Yaning , Wang Hui , Gao Yuan , Zhang Yurong 
Published: December 2022

AbstractThe effects of chronic occupational noise exposure on hypertension are debated. We aimed to investigate the association between occupational noise exposure and the prevalence of hypertension. The cross‐sectional data were collected from 2017 to 2018 using occupational physical examination data from a local aircraft manufacturing enterprise in Xi'an. We categorized occupational noise exposure as high (≥85 dBA) and low noise exposure (< 85 dBA). Logistic regression analysis was performed to evaluate the association between occupational noise exposure and hypertension, and associations were further evaluated using subgroup analyses for age, sex, and body mass index (BMI). Of the 4746 participants (median age, 43 years; 73.4% men), 9.57% (454/4746) had hypertension and 32.4% (1540/4746) were exposed to high noise. Compared to the participants with low occupational exposure to noise, the adjusted odds ratio (OR) for hypertension prevalence was 1.30 (1.05–1.62) for those with high occupational noise exposure. Subgroup analyses revealed that the noise‐hypertension association only existed in young participants (OR, 1.70; 95% CI, 1.21–2.40). This study revealed a harmful association between high occupational noise exposure and hypertension in young adults. The study suggests occupational noise exposure as a target for worksite interventions to prevent hypertension.