bluuebunny/crossref_metadata_2025_split huggingface dataset:
State-of-the-art Membrane Processing of Solution Rich in Phenolic Compounds
Authors: Hamzah N. , Leo C. P. 
Published: July 2023

Polyphenols and phenolic acids extracted from plants are natural antioxidants with high market value. However, they are susceptible to thermal processes, and a significant loss throughout food and beverage processing has been widely reported. This work reviews the state-of-the-aft membrane processing of the solution rich in phenolic compounds. Novel membrane processing allows phenolic concentration and water recovery simultaneously without using hazardous chemicals and high temperatures. Comparing pressure-driven membrane filtration processes with the advanced membrane processes at the low pressure in this review allowed the proper process selection to concentration phenolic coumpounds. Pressure-driven membrane filtration processes, namely microfiltration, ultrafiltration, nanofiltration, and reverse osmosis, have been studied. Nanofiltration membranes offer high retention of polyphenols due to their matching molecular weight cut-off. Osmotic distillation, membrane distillation and forward osmosis are membrane processes operated at low pressure. Osmotic distillation and forward osmosis require drawing solutions with osmotic pressure differences to separate water from phenolic compounds. A similar separation is attained in membrane distillation by creating vapour pressure differences. Membrane distillation without drawing solution is recommended since membrane fouling can be mitigated using superhydrophobic membranes with self-cleaning properties.
Physical Activity Levels During School Recess in a Nationally Representative Sample of 10- to 11-Year-Olds
Authors: Wong Lan Sum , Reilly John J. , McCrorie Paul , Harrington Deirdre M. 
Published: July 2023

Purpose: School recess provides a valuable opportunity for children’s daily moderate- to vigorous-intensity physical activity (MVPA). This study aimed to quantify MVPA during school recess in a representative sample of Scottish children and examine whether recess MVPA varied by gender, socioeconomic status, season, urban/rural residency, and recess length. Method: Five-day accelerometry MVPA data were analyzed from 773 children (53.9% girls, 46.1% boys, 10- to 11-y-olds) from 471 schools. Binary logistic regression explored associations between meeting/not meeting the recommendation to spend 40% of recess time in MVPA and the aforementioned risk factors. Descriptive recess data were also analyzed. Results: Participants spent an average of 3.2 minutes (SD 2.1) in MVPA during recess. Girls engaged in 2.5 minutes (SD 1.7) of MVPA compared with 4.0 minutes (SD 2.2) for boys. Only 6% of children met the recess MVPA recommendation. The odds of girls (odds ratio 0.09; 95% confidence interval, 0.04–0.25) meeting the recommendation was lower (P < .001) compared with boys. No statistically significant differences were observed in meeting the recommendation for the other risk factors. Conclusion: Levels of MVPA during school recess are very low in Scottish children, and interventions aimed at increasing MVPA during recess are needed.
Supplemental Material: Svalbox Digital Model Database: A geoscientific window into the High Arctic
Authors: Betlem Peter , al. et 
Published: July 2023

<p>Table S1: Svalbox Digital Model Database digital outcrop models (DOMs) and identifiers. Table S2: Svalbox Digital Model Database metadata parameters, values, and descriptors. Table S3: Additional details for the framework schematic provided in Figure 3 and steps on how to recreate the Svalbox Digital Model Database elsewhere. </p>
Anomalies in the review process and interpretation of the evidence in the NICE guideline for chronic fatigue syndrome and myalgic encephalomyelitis
Authors: White Peter , Abbey Susan , Angus Brian , Ball Harriet A , Buchwald Dedra S , Burness Christine , Carson Alan J , Chalder Trudie , Clauw Daniel J , Coebergh Jan , David Anthony S , Dworetzky Barbara A , Edwards Mark J , Espay Alberto J , Etherington John , Fink Per , Flottorp Signe , Garcin Béatrice , Garner Paul , Glasziou Paul , Hamilton Willie , Henningsen Peter , Hoeritzauer Ingrid , Husain Mujtaba , Huys Anne-Catherine M L , Knoop Hans , Kroenke Kurt , Lehn Alexander , Levenson James L , Little Paul , Lloyd Andrew , Madan Ira , van der Meer Jos W M , Miller Alastair , Murphy Maurice , Nazareth Irwin , Perez David L , Phillips Wendy , Reuber Markus , Rief Winfried , Santhouse Alastair , Serranova Tereza , Sharpe Michael , Stanton Biba , Stewart Donna E , Stone Jon , Tinazzi Michele , Wade Derick T , Wessely Simon C , Wyller Vegard , Zeman Adam 
Published: July 2023

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disabling long-term condition of unknown cause. The National Institute for Health and Care Excellence (NICE) published a guideline in 2021 that highlighted the seriousness of the condition, but also recommended that graded exercise therapy (GET) should not be used and cognitive–behavioural therapy should only be used to manage symptoms and reduce distress, not to aid recovery. This U-turn in recommendations from the previous 2007 guideline is controversial.We suggest that the controversy stems from anomalies in both processing and interpretation of the evidence by the NICE committee. The committee: (1) created a new definition of CFS/ME, which ‘downgraded’ the certainty of trial evidence; (2) omitted data from standard trial end points used to assess efficacy; (3) discounted trial data when assessing treatment harm in favour of lower quality surveys and qualitative studies; (4) minimised the importance of fatigue as an outcome; (5) did not use accepted practices to synthesise trial evidence adequately using GRADE (Grading of Recommendations, Assessment, Development and Evaluations trial evidence); (6) interpreted GET as mandating fixed increments of change when trials defined it as collaborative, negotiated and symptom dependent; (7) deviated from NICE recommendations of rehabilitation for related conditions, such as chronic primary pain and (8) recommended an energy management approach in the absence of supportive research evidence.We conclude that the dissonance between this and the previous guideline was the result of deviating from usual scientific standards of the NICE process. The consequences of this are that patients may be denied helpful treatments and therefore risk persistent ill health and disability.
Admission blood eosinophil count, inpatient death and death at 1 year in exacerbating patients with COPD
Authors: Echevarria Carlos , Steer John , Prasad Arun , Quint Jennifer K , Bourke Stephen C 
Published: July 2023

BackgroundBlood eosinophil counts have been studied in patients with stable chronic obstructive pulmonary disease (COPD) and are a useful biomarker to guide inhaled corticosteroid use. Less is known about eosinophil counts during severe exacerbation.MethodsIn this retrospective study, 2645 patients admitted consecutively with COPD exacerbation across six UK hospitals were included in the study, and the clinical diagnosis was confirmed by a respiratory specialist. The relationship between admission eosinophil count, inpatient death and 1-year death was assessed. In a backward elimination, Poisson regression analysis using the log-link function with robust estimates, patients’ markers of acute illness and stable-state characteristics were assessed in terms of their association with eosinopenia.Results1369 of 2645 (52%) patients had eosinopenia at admission. Those with eosinopenia had a 2.5-fold increased risk of inpatient death compared with those without eosinopenia (12.1% vs 4.9%, RR=2.50, 95% CI 1.88 to 3.31, p<0.001). The same mortality risk with eosinopenia was seen among the subgroup with pneumonic exacerbation (n=788, 21.3% vs 8.5%, RR=2.5, 95% CI 1.67 to 2.24, p<0.001). In a regression analysis, eosinopenia was significantly associated with: older age and male sex; a higher pulse rate, temperature, neutrophil count, urea and C reactive protein level; a higher proportion of patients with chest X-ray consolidation and a reduced Glasgow Coma Score; and lower systolic and diastolic blood pressure measurements and lower oxygen saturation, albumin, platelet and previous admission counts.DiscussionDuring severe COPD exacerbation, eosinopenia is common and associated with inpatient death and several markers of acute illness. Clinicians should be cautious about using eosinophil results obtained during severe exacerbation to guide treatment decisions regarding inhaled corticosteroid use.
Impact of Median Sternotomy on Safety and Efficacy of the Subcutaneous Implantable Cardioverter Defibrillator
Authors: Sugrue Alan , Ibrahim Rand , Lu Marvin , Bhatia Neal K. , Alkukhun Laith , Adewumi Joseph , Schaller Robert D. , Marchlinski Francis E. , D’Souza Benjamin , Nazer Babak , Tzou Wendy , Merchant Faisal M. , Frankel David S. 
Published: July 2023

BACKGROUND:
Subcutaneous implantable cardioverter defibrillators (S-ICDs) are an attractive alternative to transvenous ICDs among those not requiring pacing. However, the risks of damage to the S-ICD electrode during sternotomy and adverse interactions with sternal wires remain unclear. We sought to determine the rates of damage to the S-ICD lead during sternotomy, inappropriate shocks from electrical noise due to interaction with sternal wires, and failure to terminate spontaneous or induced ventricular arrhythmias.

METHODS:
Retrospective, multicenter study of patients undergoing sternotomy before or after S-ICD implantation. Clinical, procedural, and device-related data were collected by each center and analyzed by the coordinating center. These data were compared with a historical control cohort of nonsternotomy patients.

RESULTS:
Of 196 identified patients (52±16 years, 47 women), 166 underwent S-ICD implantation after sternotomy and 30 sternotomy after S-ICD. There was no damage to any lead among those who underwent sternotomy after S-ICD. Defibrillation threshold testing was performed in 63% at implant, with 91% first shock success. During a median follow-up of 29 months (range, 1–188), S-ICD first shocks successfully terminated spontaneous ventricular arrhythmias in 31 of 32 patients (97%). Inappropriate shocks occurred in 22 patients, most commonly related to T wave oversensing (n=14). Compared with the nonsternotomy controls, there were no differences in rates of first shock success for induced or spontaneous arrhythmias or rate of inappropriate shocks.

CONCLUSIONS:
Sternotomy before or after S-ICD does not confer additional risk relative to a historical control group without sternotomy.
Using social interaction models for genetic analysis of skin damage in gilts
Authors: Leite Natália Galoro , Knol Egbert , Tsuruta Shogo , Nuphaus Stefanie , Vogelzang Roos , Lourenco Daniela 
Published: July 2023

Abstract
Background
Skin damage is a trait of economic and welfare importance that results from social interactions between animals. These interactions may produce wound signs on the gilt’s skin as a result of damage behavior (i.e., fighting), biting syndromes (i.e., tail, vulva, or ear biting), and swine inflammation and necrosis syndrome. Although current selection for traits that are affected by social interactions primarily focuses on improving direct genetic effects, combined selection on direct and social genetic effects could increase genetic gain and avoid a negative response to selection in cases of competitive behavior. The objectives of this study were to (1) estimate variance components for combined skin damage (CSD), with or without accounting for social genetic effects, (2) investigate the impact of including genomic information on the prediction accuracy, bias, and dispersion of CSD estimated breeding values, and (3) perform a single-step genome-wide association study (ssGWAS) of CSD under a classical and a social interaction model.

Results
Our results show that CSD is heritable and affected by social genetic effects. Modeling CSD with social interaction models increased the total heritable variance relative to the phenotypic variance by three-fold compared to the classical model. Including genomic information increased the prediction accuracy of direct, social, and total estimated breeding values for purebred sires by at least 21.2%. Bias and dispersion of estimated breeding values were reduced by including genomic information in classical and social interaction models but remained present. The ssGWAS did not identify any single nucleotide polymorphism that was significantly associated with social or direct genetic effects for CSD.

Conclusions
Combined skin damage is heritable, and genetic selection against this trait will increase the welfare of animals in the long term. Combined skin damage is affected by social genetic effects, and modeling this trait with a social interaction model increases the potential for genetic improvement. Including genomic information increases the prediction accuracy of estimated breeding values and reduces their bias and dispersion, although some biases persist. The results of the genome-wide association study indicate that CSD has a polygenic architecture and no major quantitative trait locus was detected.
Applying the theory of planned behavior for prediction of oocyte donation intention among Iranian women
Authors: Balochi Hanie , Hadizadeh-Talasaz Fatemeh , Bahri Narjes , Mohammadzadeh Fatemeh 
Published: July 2023

Abstract
Background
Oocyte donation is a complex and multifaceted behavior in women. Due to the acute deficiency of donated oocytes, it is necessary to identify the factors affecting the desire to donate. Planned behavior theory is a suitable model for explaining and predicting behavior in many behavioral domains. The aim of this study was to predict oocyte donation intention using the theory of planned behavior.

Methods
This cross-sectional study was performed on 556 women who were covered by the comprehensive health service centers in Gonabad and Neyshabour cities in 2020. Sampling was performed by the two-step method in Gonabad city and by the convenience sampling method in Neyshabour city. Data were collected online using researcher-made questionnaires included oocyte donation awareness questionnaire and oocyte donation intention questionnaire (based on the TPB constructs). The validity of the questionnaires was confirmed by face and content validity and its reliability was confirmed by Cronbach's alpha coefficient. Data were analyzed in SPSS software (version 16) using hierarchical linear regression. The statistical significance was considered as P < 0.05.

Results
The results showed that there was a significant positive correlation between the oocyte donation intention with all constructs of planned behavioral theory (P < 0.050). Planned behavior theory constructs explained 47% of the variance of oocyte donation intention. In addition, constructs of perceived power (β = 0.461), control beliefs (β = 0.154) and normative beliefs (β = 0.125) were the strongest predictors of oocyte donation intention, respectively.

Conclusion
Planning and implementing educational courses according to the constructs of the theory of planned behavior can be a great step toward the elimination of oocyte deficiency and infertility problems. Also performing of intervention or training strategies in the field of oocyte donation requires the enhancement of social norms and perceived behavioral control in the population under study.
Ultrasound-stimulated microbubbles enhancement of fractionated radiation for tumor treatment
Authors: Sharma Deepa , McNabb Evan , Law Niki , Cumal Aaron , Czarnota Gregory J 
Published: July 2023

Abstract
Background
Radiation therapy (XRT) causes numerous biological changes in tumor microenvironment. Radiation vascular response, due to endothelial disruption, can influence treatment outcomes in a dose-dependent manner. Ultrasound-stimulated microbubbles (USMB) have also been demonstrated to create a vascular response in the tumor microenvironment and enhance tumor response when used in combination with XRT. Single doses of 8–10 Gy are known to induce activation of acid sphingomyelinase (ASMase)-induced ceramide production, causing vascular damage. Destruction of vasculature results in endothelial apoptosis followed by tumor cell death. The effect of tumor response is known to be synergistic by 10-fold higher cell kill observed when USMB is combined with radiation.

Methods
In this study, we used an USMB approach in combination with conventional low dose fractionated radiation to enhance endothelial cell responses to XRT in human PC3 prostate cancer xenograft model. Mice were divided into untreated, USMB therapy, fractionated XRT, and combined USMB therapy followed by XRT (USMB + XRT) groups. USMB therapy was delivered twice per week in the USMB-alone and combined USMB + XRT treatment groups over four weeks. Radiation treatments were delivered in fractions of 2 Gy/day (total 40 Gy in 20 fractions, BED10 = 48 Gy) in the XRT-alone and combined USMB + XRT groups. The treatment outcome was evaluated using histopathology, power Doppler, and immunohistochemistry assays.

Results
Tumor growth assessment showed that sizes of tumors increased in the control and the single treatment groups over a treatment period of four weeks, but significantly decreased with the combined treatments of USMB + XRT. Immunohistochemical analysis indicated a statistically significant vascular disruption in mice that received treatment involving a full 4-week schedule of combined (USMB + XRT) treatments. A statistically significant increase in vascular disruption was demonstrated through CD68 and trichrome fibrosis staining. Changes in local perfusion assessed using high-frequency power Doppler imaging demonstrated attenuated blood flow in the combined group.

Discussion and conclusions
This work demonstrates the efficacy of using USMB as a radiation sensitizer in a mouse model of human PC3 tumor xenograft. This radiation treatment enhancement modality has the advantage of targeting tumor vasculature with ultrasound stimulation that can be implemented prior to radiation treatment.
A novel PEGylated form of granulocyte colony-stimulating factor, mecapegfilgrastim, for peripheral blood stem cell mobilization in patients with hematologic malignancies
Authors: Wen Jingjing , Zhou Qiaolin , Shi Lin , Xu Fang , Liu Yiping , Su Jing , Zhang Ya , Qu Wen , Yue Jing 
Published: July 2023

Abstract
Background
The Pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) has longer half-life and is given once only, which is more comfortable for patients. We aimed to evaluate the efficacy of mecapegfilgrastim for hematopoietic stem cell (HSC) mobilization in patients with hematologic malignancies and to explore the potential factors related to HSC mobilization.

Methods
A retrospective analysis was performed on patients who underwent HSC mobilization in the hematology department of Mianyang Central Hospital from April 2016 to November 2022. The number of CD34 + cells collected was compared between the patients receiving mecapegfilgrastim (PEG group) and those receiving recombinant human granulocyte colony-stimulating factor (rhG-CSF group), and the possible factors for mobilization failure were analyzed.

Results
The success rates of collecting CD34 + cells in the PEG group and rhG-CSF group were 80.6% and 67.7%, respectively (χ = 1.444, P = 0.229). The median CD34 + cell counts were 3.62 × 10^6/kg and 2.92 × 10^6/kg (P = 0.178), respectively. After combination with plerixafor for mobilization, the median number of CD34 + cells collected in the PEG group and rhG-CSF group were 3.64 × 10^6/kg and 3.92 × 10^6/kg, respectively, with no significant difference (P = 0.754). There was no significant difference in hematopoietic cell recovery or infection between the groups (P > 0.05). Multivariate analysis showed that more than 5 cycles of chemotherapy (OR = 15.897, 95% CI: 1.766-143.127, P = 0.014), a precollection WBC count < 32 × 10^9/L (OR = 14.441, 95% CI: 2.180-95.657, P = 0.006) and a precollection to premobilization lymphocyte ratio < 1.7 (OR = 11.388, 95% CI: 2.129–60.915, P = 0.004) were independent risk factors for HSC mobilization failure.

Conclusions
The HSC mobilization efficacy of mecapegfilgrastim in patients with hematologic malignancies was comparable to that of rhG-CSF, and combination with plerixafor for mobilization was feasible and effective. Patients with more than 5 cycles of chemotherapy before HSC mobilization, a precollection WBC count lower than 32 × 10^9/L, and a precollection lymphocyte count less than 1.7 times the premobilization lymphocyte count have a high probability of HSC mobilization failure.
Depression and its association with psychological factors among adolescents living with HIV in Southwestern Nigeria
Authors: RO Lawal , Akinsulore Adesanmi , OA Oginni , OO Aloba , SK Mosaku , AS Akanmu 
Published: July 2023

Abstract
Objective
The aim was to determine the prevalence of depressive disorder and associated psychological factors among adolescents living with HIV/AIDS.

Methods
One hundred and five adolescents with HIV were assessed for self-esteem, internalized HIV stigma and diagnosed of depressive disorder. Chi square and t tests were used to test associations and hierarchical logistic regression used to identify independent risk factors for depression.

Results
The mean age of participants was 16.5 (± 1.97) years and 55.2% were males. Mean stigma scores were significantly higher in those with depressive disorder (16.53 ± 3.85) when compared with those without (13.42 ± 3.464) and this difference was statistically significant (t = 3.17, p = 0.01). The mean self-esteem scores were significantly lower in participants with depressive disorder (17.53 ± 4.69) compared to those without depressive disorder (19.71 ± 3.86), though not significant (t = 1.96, p = 0.053). Depressive disorder was further significantly associated with female sex, being in romantic relationship, decline in work output due to HIV and HIV stigma. Independent risk factors were sex and HIV stigma.

Conclusion
Depressive disorder is common among adolescents living with HIV infection in Nigeria. The association between HIV stigma and depression, thus suggests the need for prevention strategies targeting the impacts of HIV infection among adolescents.