bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative evaluation of the effect of 2% graphene oxide and 5% hydroxyapatite nanoparticles in isolation and in combination on micro tensile bond strength of 5th generation adhesive
Authors: Kriplani Simran , Sedani Shweta 
Published: May 2023

Graphene is the thinnest, strongest and stiffest imaginable material. The biocompatible property of graphene oxide can initiate and facilitate cell adhesion, proliferation and differentiation of periodontal ligament, osteogenic and oral epithelial cells. Furthermore, the antibiofilm and anti-adhesion properties of graphene oxide in prevention of dental biofilm infections, dental caries, dental erosion as well as for implant surface modification and as anti-quorum sensing agent. Composites are most often utilised materials for restoration in the field of dentistry due to adhesive resins' improved mechanical and cosmetic properties. To safeguard the dentin and prevent dental cavities, dentin adhesives are utilised to affix hydrophobic resin composites to hydrophilic dentin tissue. Dental adhesives have a harder time adhering to dentin because it contains more water and is less mineralized than enamel. This makes the method more sensitive. As a result, it was chosen to assess and contrast the impact of 5% Hydroxyapatite nanoparticles and 2% Graphene oxide nanoparticles, both separately and together, on the Micro tensile bond strength of 5th generation adhesive. Graphene oxide is the most versatile form of Graphite in structural and functional configuration. Graphene oxide possess extraordinary physical, chemical, optical, electrical and mechanical properties. Among the graphene family nanomaterials, the reduced form of Graphite adding the oxygenated functional group to the structure increases the surface area and therefore exhibits enviable excellent interaction ability with metal and ions as well as organic species. Graphene oxide in dentistry has provided outstanding results in antimicrobial action, regenerative dentistry, bone tissue engineering, drug delivery, physicochemical property, enhancement of dental biomaterials and oral cancer treatment.
The journey of F1000Research since inception: through bibliometric analysis
Authors: Kumar Dilip , Shandilya Abhinav Kumar , Srivastava Sandeep 
Published: May 2023

Background: Bibliometric analysis is an approach adopted by researchers to understand the various analytics such as year-wise publications, their citations, most impactful authors and their contributions, identification of emerging keywords, multiple themes (niche, motor, basic, and emerging or declining) etc. F1000Research is one of the Q1 category journals that publishes articles in various domains, but a detailed journal analysis is yet to be done. Methods: This study is an effort to extract the F1000Research journey information through bibliometric analysis using VOS-viewer and Biblioshiny (R-studio) interface. The F1000Research journal started its journey in 2012; since then, 5767 articles have been published until the end of 2022. Most of the published articles are from medical science, covering Biochemistry, Genetics & Molecular Biology, Immunology & Pharmacology, Toxicology & Pharmaceutics. To understand the research journey, various analyses such as publication & citation trends, leading authors, institutions, countries, most frequent keywords, bibliographic coupling between authors, countries and documents, emerging research themes, and trending keywords were performed. Results: The United States is the biggest contributor, and COVID-19 is the most commonly occurred keyword. Conclusions: The present study may help future researchers to understand the emerging medical science domain. It will also help the editors and journal to focus more on developing or emerging areas and to understand their importance towards society. Future researchers can contribute their quality research studies, focusing on emerging themes. These authors’ research can guide future researchers to develop their research area around the most impacted articles. They can collaborate with them to bring that emerging theme forward.
SPORTS BOARD GAMES AS A MEANS OF PHYSICAL EDUCATION FOR STUDENTS OF SPECIAL MEDICAL GROUPS IN THE CONTEXT OF THE INCLUSIVE EDUCATION DEVELOPMENT
Authors: Kozlov Aleksey V. , Kulkova Irina V. , Kozlova Maria A. 
Published: May 2023

The article deals with the nuances of organizing work on physical education with students of SMG (special medical groups) by means of sports board games.
The relevance of the study is substantiated by the need to search for new forms of physical activity of students with disabilities (limited health).
The aim of the study is to analyze physical culture and health-improving activity in higher educational institutions using the example of a competitive event in sports board games among students of a special medical group and the main health group (MHG). The emphasis of the work is made on the need to introduce board sports games into the educational activities of higher professional institutions. It is concluded that sports board games contribute to the development of an inclusive educational environment, are a good means of health preservation and are suitable for students with any type of pathology.
Methodology. In accordance with the intended scientific goal and the results of the scientific experiment, points were calculated and converted into a percentage.
Results. As a result of the study, the effectiveness of the use of table sports for the development of an inclusive educational environment in higher educational institutions has been scientifically substantiated and experimentally proven.
Practical implications. The practical application and introduction of board sports games into the educational process will help teachers and teachers of universities and colleges to adapt extracurricular and competitive activities for students of a special medical group.
Game—FloraPark (the Flower Game): A Supply Chain Contract and Collaboration Simulation
Authors: Zhao Yao , Park Arim , Rudna Olena , Song Ju Myung 
Published: May 2023

Intensive competition among supply chains often forces trading partners to collaborate despite their conflict of interests. Supply chain contracts and collaboration theory is well established in the academic literature to align the interests but much less conveyed to students and industry professionals for a practical impact. Although the Beer Game captures the bullwhip effect and the value of information sharing, it ignores the conflict of interests, that is, price and quantity bargaining, among the trading partners. We describe a new online teaching game, the FloraPark simulation (“the flower game” at https://flower.gamespots.net/ ), based on real-life events in the international fresh-cut flower supply chains, for students to learn supply chain collaboration via contracts in a setting of multiple supply chains competing in the same market. Students play trading partners in the flower supply chains and experiment with the push, pull, and advanced purchasing discount contracts by negotiating wholesale prices and quantities to achieve the conflicting objectives of (1) collaboration to beat other supply chains, and (2) bargaining to protect their own interests from their trading partners. Supplemental Material: The e-companion is available at https://doi.org/10.1287/ited.2022.0035 .
The Real Effects of Ratings Actions: Evidence from Corporate Asset Sales
Authors: Bongaerts Dion , Schlingemann Frederik 
Published: May 2023

We investigate whether and through which channel credit rating downgrades induce corporate restructurings. For a comprehensive sample, we find a strong and robust link between rating actions and subsequent restructuring activity and hypothesize these could be disciplinary (ex post efficient) or meant to counter tighter financial constraints (ex post inefficient). Based on the self-reported restructuring types and the choice of assets sold, we find evidence for rating-induced asset sales aimed to relax financial constraints. We find no evidence of firms addressing inefficiencies in their assets allocations as a result of rating actions. This paper was accepted by Victoria Ivashina, finance. Funding: F. Schlingemann gratefully acknowledges the financial support from the Barry J. Epstein Fellowship and the H.R. and Betty Young Fellowship. D. Bongaerts gratefully acknowledges the financial support from the Nederlandse Organisatie voor Wetenschappelijk Onderzoek Veni grant [Grant 016.135.059]. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4754 .
Resonant-cavity-enhanced infrared detector incorporating an ultra-thin type-II superlattice: design and simulation
Authors: Feng Qingsong , Liu Bingfeng , Chen Yang , Gong Ruixin , Zhu Lianqing , Liu Yuan , Dong Mingli 
Published: May 2023

A resonant-cavity-enhanced type-II superlattice (T2SL) infrared
detector based on a metal grating has been designed to address the
weak photon capture and low quantum efficiency (QE) issues of T2SL
infrared detectors. Simulations have been conducted to analyze the
effects of metal grating parameters, including length, thickness, and
incident angle, on the spectral response and absorptivity of the
absorption layers in T2SL infrared detectors. By optimizing the
design, an appropriate resonant cavity structure was obtained.
Research results indicate that the resonant cavity structure can
significantly enhance the absorption rate of a T2SL infrared detector
with a 0.2 µm thick absorption layer in the 3–5 µm
wavelength range, observing peak absorption rates at 3.82 µm
and 4.73 µm, with values of 97.6% and 98.2%, respectively. The
absorption rate of the 0.2 µm thick T2SL absorption layer at
peak wavelengths increased from 6.03% and 2.3% to 54.48% and 27.91%,
respectively. The implementation of the resonant-cavity-enhanced T2SL
infrared detector improves the QE while reducing absorption layer
thickness, thus opening up new avenues for improving T2SL detector
performance.
Optical design of a reflective double-grating spectrometer to detect one branch in the pure rotational Raman spectrum of N2
Authors: Wang Lifu , Chen He , Zhang Yinchao , Chen Siying , Guo Pan , Tan Wangshu , Jiang Yurong , Li Xin 
Published: May 2023

This paper presents the optical design of a high-resolution double-grating spectrometer for extracting the multiple lines in the Stokes or anti-Stokes branch of the pure rotational Raman spectra of nitrogen. The spectrometer is composed of collimating and focusing mirrors, two reflective gratings, and a linear detector. The structural parameters were calculated using geometric configuration, dispersion, and aberrational theory, and conditions for first-order correction of keystone distortion with divergent grating illumination were derived. Based on this method, we simulated a spectrometer with a 16-channel linear array photomultiplier tube, resulting in uniformly distributed single-branch lines on each detector channel. The resolution reached 0.225 nm per channel, and the keystone distortion was less than 0.7%. The spectrometer avoids the interference of elastic signals by not detecting them, enabling the extraction of atmospheric temperature profiles via separated single-branch lines with high precision. Our design provides a promising solution to extract atmospheric temperature profiles for pure rotational Raman lidar.
Adaptive Optics for Satellite Laser Communications
Authors: Saito Yoshihiko , Kolev Dimitar , Nakazono Jun , Abe Yuma , Toyoshima Morio 
Published: May 2023

The development of laser communication technology between satellites and ground stations has been paid attention recently. On the other hand, the laser communication between satellites and ground stations is always affected by the atmospheric condition. We can compensate this effect by applying the technology of Adaptive Optics that is used for astronomical observation.
We started the development of Adaptive Optics for laser communication in NICT from 2019 and completed the manufacture of Adaptive Optics for Koganei 1-m telescope in 2021 fiscal year. We performed the initial inspection of the performance of this system in March 2022. Although it was just simulation using artificial light source in our inspection, we can confirm the performance of AO of Koganei 1-m telescope is enough to improve the fiber coupling efficiency. In this paper, we describe the detail of Adaptive Optics for laser communication in NICT.
Towards implementation of context-specific integrated district mental healthcare plans: A situation analysis of mental health services in five districts in Ghana
Authors: Weobong Benedict , Ae-Ngibise Kenneth Ayuurebobi , Sakyi Lionel , Lund Crick 
Published: May 2023

BackgroundAccess to quality mental health services in Ghana remains poor, yet little is known about the extent of the access gaps and provision of mental health services at the district level in Ghana. We aimed to conduct an analysis of mental health infrastructure and service provision in five districts in Ghana.MethodsA cross-sectional situation analysis was conducted using a standardised tool to collect secondary healthcare data, supplemented by interviews with key informants, across five purposively selected districts in Ghana. The Programme for Improving Mental Health Care (PRIME) situation analysis tool was adapted to the Ghanaian context and used for data collection.ResultsThe districts are predominantly rural (>60%). There were severe challenges with the provision of mental healthcare: there were no mental healthcare plans, supervision of the few mental health professionals was weak and unstructured, access to regular supplies of psychotropic medications was a major challenge, and psychological treatments were extremely limited given the lack of trained clinical psychologists. There were no available data on treatment coverage, but we estimate this to be <1% for depression, schizophrenia, and epilepsy across districts. Opportunities for mental health systems strengthening include: the commitment and willingness of leadership, the existence of the District Health Information Management System, a well-established network of community volunteers, and some collaboration with traditional and faith-based mental health service providers.ConclusionThere is poor mental health infrastructure across the five selected districts of Ghana. There are opportunities for strengthening mental health systems through interventions at the district healthcare organisation, health facility, and community levels. A standardised situation analysis tool is useful for informing district-level mental healthcare planning in low-resource settings in Ghana and potentially other sub-Saharan African countries.
Eight versus twelve weeks of sofosbuvir-velpatasvir in treatment-naïve non-cirrhotic patients with chronic hepatitis C virus infection: Study protocol for a multicentric, open labelled, randomized, non-inferiority trial (RESOLVE trial)
Authors: Awasthi Ashish , Katiyar Harshita , Rungta Sumit , Deep Amar , Kumar Vinod , Shalimar  , Kumar Ajay , Tiwari Prachi , Goel Amit 
Published: May 2023

BackgroundHepatitis C virus (HCV) is a common cause of liver cirrhosis and hepatocellular carcinoma. Globally, nearly 71 million people have chronic HCV infection, and approximately 399,000 dies annually. In patients without cirrhosis, HCV infection is treated with 12 weeks of sofosbuvir/velpatasvir combination. Results from available small, single-centre observational studies suggest that the sofosbuvir/velpatasvir combination given for 8 weeks may be as effective as the standard 12 weeks of treatment. We propose to compare the treatment response of 12 weeks versus 8 weeks of sofosbuvir/velpatasvir in non-cirrhotic people with chronic HCV infection.MethodsThis multicentric, randomized, open-label, non-inferiority trial will include 880 (2 arms x 440) treatment naïve, viraemic (HCV RNA >10,000 IU/mL), non-cirrhotic adults (age >18 years) with chronic hepatitis C. People who are at high-risk for HCV reinfection such as haemophiliacs, people who inject drugs, those on maintenance hemodialysis or having HIV will be excluded. The presence or absence of cirrhosis will be determined with a combination of history, examination, ultrasound, liver stiffness measured with transient elastography, APRI, FIB-4, and esophagogastroduodenoscopy. Participants will be randomized to receive either 8- or 12-week sofosbuvir/velpatasvir treatment. A blood specimen will be collected before starting the treatment (to determine the HCV genotype), after 4 weeks of treatment (for early virological response), and at 12 weeks after treatment discontinuation for SVR12.DiscussionThe study will provide data on the efficacy of 8 weeks of treatment as compared to the standard of care (12 weeks) in non-cirrhotic patients with chronic HCV infection. Treatment for a shorter duration may improve treatment compliance, reduce the cost of treatment, and ease the treatment implementation from a public health perspective.Trial registrationRegistered with Clinical Trial Registry of India (http://ctri.nic.in) Registration No.CTRI/2022/03/041368[Registered on: 24/03/2022]—Trial Registered Prospectively.
Presence and activity of Fibrinogen like protein 2 in platelets
Authors: Cherny Izhack , Hasin Pinhas , Philosoph Lital Kalich , Shahal-Zimra Yael , Gurion Ronit , Rabizadeh Esther 
Published: May 2023

Background
Fibrinogen-like protein 2 (FGL2) is a serine protease capable of converting prothrombin into thrombin (i.e., prothrombinase-like activity) while bypassing the classic coagulation cascade. It has been reported to be expressed by mononuclear blood cells and endothelial cells. There are multiple reports that FGL2 supports tumor development and metastasis. However, in the blood, the origin and functional significance of FGL2 has not been established.

Objective
To determine if FGL2, a malignancy related enzyme, is present in platelets.

Methods
Peripheral blood samples were collected in K2 EDTA tubes. Blood cells and platelets were separated and thoroughly washed to produce plasma-free samples. Procoagulant activity was measured in the cell lysates using a thrombin generation test or an adjusted prothrombin time (PT) test in plasma deficient of factor X. The findings were further supported by confocal microscopy, immunoprecipitation, flow cytometry, enzyme-linked immunosorbent assays and specific inhibition assays.

Results
FGL2 protein was readily detected in platelets. Also, despite being expressed by lymphocytes, FGL2 prothrombinase-like activity was solely detected in platelet samples, but not in white blood cell samples. Quiescent platelets were shown to contain the FGL2 protein in an active form. Upon activation, platelets secreted the active FGL2 into the milieu.

Conclusions
Active FGL2 is found in platelets. This suggests another role for the involvement of platelets in malignancies.
Association between cancer stigma and cervical cancer screening uptake among women of Dhulikhel and Banepa, Nepal
Authors: Paneru Bandana , Karmacharya Aerona , Bharati Alina , Makaju Soniya , Adhikari Bikram , Kafle Dikshya , Shakya Sunila , Spiegelman Donna , Seth Sangini , Stangl Anne , Shrestha Aamod Dhoj , Shrestha Archana 
Published: May 2023

Background
Cervical cancer ranks as the most common cancer among Nepalese women with a high incidence and mortality. Despite evidence that effective screening programs reduce disease burden, screening services are under-utilized. Cancer stigma can be a major barrier to cervical cancer screening uptake among Nepalese women.

Objectives
This study assessed the association between cancer stigma and cervical cancer screening uptake among women residing in semi-urban areas of Kavrepalanchok district (Dhulikhel and Banepa), Nepal.

Methods
We conducted a cross-sectional study among 426 women aged 30–60 years using telephone interview method from 15th June to 15th October 2021. A validated Cancer Stigma Scale (CASS) was used to measure cancer stigma and categorized women as presence of cancer stigma if the mean total score was greater than three. We obtained information on cervical cancer screening uptake through self-reported responses. Univariable and multivariable logistic regression were performed to assess the association between cancer stigma and cervical cancer screening uptake. We adjusted socio-demographic: age, ethnicity, occupation, religion and education, and reproductive health variables: parity, family planning user, age of menarche and age at first sexual intercourse during multivariable logistic regression.

Results
Twenty-three percent of women had cancer stigma and 27 percent reported that they had ever been screened for cervical cancer. The odds of being screened was 0.23 times lower among women who had stigma compared to those who had no stigma (95% CI: 0.11–0.49) after adjusting for confounders: age, ethnicity, occupation, religion, education, parity, contraceptive use, age of menarche and age at first sexual intercourse.

Conclusion
Women residing in semi-urban areas of Nepal and had cancer stigma were less likely to have been screened for cervical cancer. De-stigmatizing interventions may alleviate cancer stigma and contribute to higher uptake of cervical cancer screening.
Coping with the mental health impact of COVID–19: A study protocol for a multinational longitudinal study on coping and resilience during the COVID-19 pandemic
Authors: Backhaus Insa , Sisenop Felix , Begotaraj Edvaldo , Jevtic Marija , Marchini Simone , Morganti Alessandro , Pirlog Mihail Cristian , Vinko Matej , Kusturica Milica P. , Lindert Jutta ,   the COPERS consortium
Published: May 2023

BackgroundMental health is challenged due to serious life events such as the COVID-19 pandemic and can differ by the level of resilience. National studies on mental health and resilience of individuals and communities during the pandemic provide heterogeneous results and more data on mental health outcomes and resilience trajectories are needed to better understand the impact of the pandemic on mental health in Europe.MethodsCOPERS (Coping with COVID-19 with Resilience Study) is an observational multinational longitudinal study conducted in eight European countries (Albania, Belgium, Germany, Italy, Lithuania, Romania, Serbia, and Slovenia). Recruitment of participants is based on convenience sampling and data are gathered through an online questionnaire. gathering data on depression, anxiety, stress-related symptoms suicidal ideation and resilience. Resilience is measured with the Brief Resilience Scale and with the Connor-Davidson Resilience Scale. Depression is measured with the Patient Health Questionnaire, Anxiety with the Generalized Anxiety Disorder Scale and stress-related symptoms with the Impact of Event Scale Revised- Suicidal ideation is assessed using item 9 of the PHQ-9. We also consider potential determinants and moderating factors for mental health conditions, including sociodemographic characteristics (e.g., age, gender), social environmental factors (e.g., loneliness, social capital) and coping strategies (e.g., Self-efficacy Belief).DiscussionTo the best of our knowledge, this is the first study to multi-nationally and longitudinally determine mental health outcomes and resilience trajectories in Europe during the COVID-19 pandemic. The results of this study will help to determine mental health conditions during the COVID-19 pandemic across Europe. The findings may benefit pandemic preparedness planning and future evidence-based mental health policies.