bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early carotid pulse waves are associated with an acceleration of 18 F-FDG PET hypometabolism in Alzheimer’s brain areas
Authors: Zimmermann Gaétan , Joly Laure , Schoepfer Pauline , Doyen Matthieu , Roch Veronique , Grignon Rachel , Salvi Paolo , Marie Pierre-Yves , Benetos Athanase , Verger Antoine 
Published: July 2023

Abstract
Background Arterial stiffening likely plays a role in Alzheimer disease (AD) pathogenesis and may also favour a potentially deleterious early return of reflected arterial pressure waves. The current study investigated whether inter-individual variations in arterial stiffness and pressure wave parameters were associated with 18F-FDG positron emission tomography (PET) metabolism in AD-associated brain areas independently of age and before the onset of any neuropsychological disorders.Methods A prospective, large age-range population of 67 patients (17 young, 16 middle-aged, and 34 older adults; 37 women) with normal neuropsychological tests, underwent a: 1) brain 18F-FDG PET, 2) blood pressure recording and 3) carotid/femoral pulse wave-based measurements, including the time-to-peak of the reflected backward carotid pulse wave (bT), on the same day. Multivariate and quantitative voxel-to-voxel analyses (p-voxel < 0.005, corrected for cluster volumes) were conducted to assess associations between vascular parameters and 18F-FDG PET metabolism in AD-associated brain areas.Results In the multivariate analysis, only increased age and decreased bT were independently associated with the decline of metabolic activity in AD-associated brain areas (p < 0.001). In the voxel-to-voxel analysis with age as a covariate, bT was strongly associated with the metabolic activity of 40 clusters in AD-associated brain areas (clusters cumulative volume: 63 cm3; T score max: 5.7).Conclusion In patients, who are still unaffected by neuropsychological disorders, an early reflected arterial pressure wave, as evidenced by a decreased bT value, is strongly associated with an acceleration of the age-related decline in the metabolic activity of AD-associated brain areas.Trial registration : This research study was approved by the local ethics committee (CPP accreditation N°2018/26; date of registration : May,11th 2018).
A Study of Obesity and Financial Stress in Workers in the United States: Findings from the NHIS 2021
Authors: Weissman Judith D. , Rogol Naomi , Jay Melanie , Taylor John 
Published: July 2023

Abstract
Purpose This cross-sectional study examined the relationship between indicators of workplace financial stress and obesity among working adults.Methods Respondents were sampled from the 2021 National Health Interview Survey. Adults were included if they worked in the last week were between 18 to 65 years (n = 14, 976). A multivariable model predicted having obesity using the following the independent variables: working full time, defined as working 35 hours per week or more, working while sick, perceived likelihood of job loss, food insecurity and sociodemographic characteristics. The multivariable model was based on bivariate analyses comparing these variables, and serious psychological distress to having obesity and the number of chronic health conditions.Results At the bivariate level 6.5% of full-time workers had food insecurity, and 9.1% perceived they were fairly likely or somewhat likely to lose their job and 45% had serious psychological distress. In a multivariable model, there was a positive association between obesity and full-time employment (AOR = 1.5 CI = 1.3, 1.7), workers perceptions of being fairly or somewhat likely to lose their job (AOR = 1.2 CI = 1.0, 1.4), and obesity and food insecurity (AOR = 1.2 CI = 1.0, 1.4) after adjusting for sociodemographic characteristics.Conclusions The relationship between having obesity and working full time, serious psychological distress, perceptions about job loss and food insecurity suggests that employment may be stressful. Despite working full time, many adults experienced food insecurity. Suggestions for increasing the safety net for workers to protect against financial and work instability are discussed.
DDT: A Reinforcement Learning Approach to Dynamic Flow Timeout Assignment in Software Defined Networks
Authors: Harris Nathan , Khorsandroo Sajad 
Published: July 2023

Abstract
OpenFlow-compliant commodity switches face challenges in efficiently managing flow rules due to the limited capacity of expensive high-speed memories used to store them. The accumulation of inactive flows can disrupt ongoing communication, necessitating an optimized approach to flow rule timeouts. This paper proposes Delayed Dynamic Timeout (DDT), a Reinforcement Learning-based approach to dynamically adjust flow rule timeouts and enhance the utilization of a switch's flow table(s) for improved efficiency. Despite the dynamic nature of network traffic, our DDT algorithm leverages advancements in Reinforcement Learning algorithms to adapt and achieve flow-specific optimization objectives.
The evaluation results demonstrate that DDT outperforms static timeout values in terms of both flow rule match rate and flow rule activity. By continuously adapting to changing network conditions, DDT showcases the potential of Reinforcement Learning algorithms to effectively optimize flow rule management. This research contributes to the advancement of flow rule optimization techniques and highlights the feasibility of applying Reinforcement Learning in the context of SDN.
Impact Assessment of Integrated-pathy on Cancer-Related Fatigue in Cancer Patients: An Observational study
Authors: Balkrishna Acharya , Katiyar Prashant , Singh Sumit Kumar , Ghosh Sourav , Arya Vedpriya 
Published: July 2023

Abstract
Background: Integrated-pathy aims to integrate modern medicine with traditional systems via applying the holistic approach of Ayurveda, Yoga, Yagya, Panchkarma and natural medicine. This is important for addressing the challenges surrounding the delivery of long-term palliative care for chronic ailments including cancer. The prime intent of this study was to substantiate the underlying hypothesis behind the differential and integrative approach having a positive impact on Quality of Life of cancer patients.
Study Design: Observational study
Methods: A standardized questionnaire was developed and used, after obtaining written informed consent from patients to assess the impact of Integrated-pathy on patients (n=103) diagnosed with cancer receiving care at Patanjali Yoggram. The research was carried out over an eight-month period (December-2021 to July-2022). For the significance of the pre- and post-treatment QoL ratings, Wilcoxon signed-rank pair test, Kolmogorov-Smirnov test and other descriptive statistics techniques were explored.
Results: A total of 103 patients seeking cancer special-healthcare were interviewed, out of which 39 (37.86%) were selected based on the inclusion/exclusion criteria with age (25-65 years), period of Integrated-pathy received (≥1 months), allopathic treatment received prior to opting for Integrated-pathy. Results revealed a significant increase in the QoL (17.91%) after receiving the integrated therapy over a course of at least one month. Further, a significant reduction in cancer related pain followed by an increase in QoL index was reported in the patients. Wilcoxon rank test revealed significant pairing (p<0.0001) with validation of the model using Kolmogorov-Smirnov test.
Conclusions: In order to enhance evidence-based support to the Integrated-pathy, well-defined clinical indicators that can be assessed and monitored over time are required. Clinical researchers should add Integrated-pathy into their proposed interventions and undertake similar studies to provide long-term benefits.
Cement- Nanosilica Stabilized Fibre Reinforced Rammed Earth: Compressive and Flexure Behaviour
Authors: A Neha Vivek , P Prasanna Kumar , Reddy Divijendranatha 
Published: July 2023

Abstract
Rammed earth (RE) is a brittle material that can undergo sudden catastrophic failures under ultimate stress. Such sudden catastrophic failures can be avoided in RE structures with the addition of randomly oriented polypropylene fibres where crack propagation can be inhibited. Further, the strength of RE can be enhanced by the addition of nanomaterials, which make RE denser because of their high specific surface area. This research deals with studies on the effect of polypropylene fibre and nanosilica on the behaviour of cement stabilized rammed earth (CRE) under compression and flexure. The effect of fibre volume fraction and nanosilica content on the strength and stress–strain characteristics has been evaluated. Three polypropylene fibre volume fractions (0.2%, 0.3% and 0.4%) and five nanosilica contents (0.2%, 0.4%, 0.6%, 0.8% and 1%) were considered in this investigation. The compressive strength of fibre reinforced CRE increased by 30% for 0.3% of polypropylene fibre content and by 41% for 0.6% of nanosilica content when compared to CRE. The strain at peak stress has significantly increased with the addition of fibres indicating improved ductility and post-peak response of the material. The microscopic analysis showed that the addition of nanosilica has contributed to a denser packing of soil particles and hence, might have increased the compressive strength.
Evaluation of the effect of Age-Related Macular Degeneration type and stage on the risk of Parkinson’s disease
Authors: Yasar Erdogan , Gurlevik Ugur , Bilgec Mustafa Deger , Gunes Muzaffer 
Published: July 2023

Abstract
Purpose
To investigate the association of Parkinson’s Disease(PD) with Age-Related Macular Degeneration(AMD) type and stage.
Methods
Our prospective study, the dry-type AMD group consisted of 296 patients with early stage and 284 patients with late-stage. The neovascular AMD group included 285 early-stage and 277 late-stage patients. The control group consisted of 300 patients who were similar in terms of age and gender. AMD patients will be grouped as dry and neovascular type, as well as the early and late-stages. The patients were questioned about the use of drugs for PD, and the use was recorded as having the disease. In the absence of drug use, detailed inquiries were made for both diseases. If any of the complaints seen in the PD was present, the patient was referred to a neurologist, and the presence or absence of the PD was confirmed.
Results
PD was detected in 1% of the control group and 4.6% in the neovascular type AMD group, and this difference was statistically significant (p:0.04). This significant difference was present in both the early stage (%4.5) and late-stage (%4.6 ) (p:0.04, p:0.04). In addition, PD was determined 3.78 times greater among neovascular AMD patients(p:0.03), and significant association was present in both early-stage (3.72 times) and late-stage (3.82 times) (p:0.03, p:0.03). In the dry-type AMD group 2.7% PD was detected and there was no statistically significant difference compared to the control group (p > 0.05). This difference was not significant in the early stage (%2.3) or late-stage (%2.8) and also there was no significant association with dry-type AMD (p > 0.05). Also, unilateral and bilateral involvement in AMD was not associated with PD disease (p > 0.05).
Conclusions
Our study revealed the relationship between early and late-neovascular AMD and PD. However, this significant relationship was not detected between early and late-neovascular AMD and PD. Common pathways mediated by dopamine reduction in neovascular AMD and Parkinson's disease may explain the association of neovascular AMD with a higher risk of Parkinson's disease.
Decoding Microbial Enigmas: Unleashing the Power of Artificial Intelligence in Analyzing Antibiotic-Resistant Pathogens and their Impact on Human Health
Authors: Yousif Maitham G. 
Published: July 2023

AbstractIn this research, medical information from 1200 patients across various hospitals in Iraq was collected over a period of 3 years, from February 3, 2018, to March 5, 2021. The study encompassed several infections, including urinary tract infections, wound infections, tonsillitis, prostatitis, endometritis, endometrial lining infections, burns infections, pneumonia, and bloodstream infections in children. Multiple bacterial pathogens were identified, and their resistance to various antibiotics was recorded. The data analysis revealed significant patterns of antibiotic resistance among the identified bacterial pathogens. Resistance was observed to several commonly used antibiotics, highlighting the emerging challenge of antimicrobial resistance in Iraq. These findings underscore the importance of implementing effective antimicrobial stewardship programs and infection control measures in healthcare settings to mitigate the spread of antibiotic-resistant infections and ensure optimal patient outcomes. This study contributes valuable insights into the prevalence and patterns of antibiotic resistance in microbial infections, which can guide healthcare practitioners and policymakers in formulating targeted interventions to combat the growing threat of antimicrobial resistance in Iraq's healthcare landscape.
The cause-effect relationship between sclerostin levels, cardiovascular biomarkers, risk factors, and cardiovascular disease
Authors: Prieto-Alhambra Daniel , Alcalde-Herraiz Marta , Xie Junqing , Newby Danielle , Prats Clara , Gill Dipender , Gordillo-Marañón María , Català Martí , Prats-Uribe Albert 
Published: July 2023

Abstract

Sclerostin inhibitors protect against osteoporotic fractures, but their cardiovascular safety remains unclear. We conducted a cis-Mendelian randomisation analysis to study the effect of sclerostin levels on cardiovascular risk factors. We meta-analysed three GWAS of sclerostin levels including 49,568 Europeans. Public GWAS were used for study outcomes, with findings validated using UK Biobank patient-level data including biomarkers. Lower sclerostin levels were associated with higher bone density and 75% reduction in hip fracture risk. However, reduced sclerostin led to 50-70% excess coronary artery disease risk, 30% to 80% increased risk of myocardial infarction, 50% to 70% increased risk of type 2 diabetes, and with worse cardiovascular biomarkers, including higher glucose, LDL cholesterol, apolipoprotein B and triglycerides, and decreased HDL cholesterol and lipoprotein A levels. We provide genetic evidence of a causal association between reduced levels of sclerostin and improved bone health and fracture protection, but increased cardiovascular events and risk factors.
Applications of Natural Language Processing for the Management of Stroke Disorders: Scoping Review
Authors: De Rosario Helios , Pitarch-Corresa Salvador , Pedrosa Ignacio , Vidal-Pedrós Marina , de Otto-López Beatriz , García-Mieres Helena , Álvarez-Rodríguez Lydia 
Published: July 2023

Background
Recent advances in natural language processing (NLP) have heightened the interest of the medical community in its application to health care in general, in particular to stroke, a medical emergency of great impact. In this rapidly evolving context, it is necessary to learn and understand the experience already accumulated by the medical and scientific community.

Objective
The aim of this scoping review was to explore the studies conducted in the last 10 years using NLP to assist the management of stroke emergencies so as to gain insight on the state of the art, its main contexts of application, and the software tools that are used.

Methods
Data were extracted from Scopus and Medline through PubMed, using the keywords “natural language processing” and “stroke.” Primary research questions were related to the phases, contexts, and types of textual data used in the studies. Secondary research questions were related to the numerical and statistical methods and the software used to process the data. The extracted data were structured in tables and their relative frequencies were calculated. The relationships between categories were analyzed through multiple correspondence analysis.

Results
Twenty-nine papers were included in the review, with the majority being cohort studies of ischemic stroke published in the last 2 years. The majority of papers focused on the use of NLP to assist in the diagnostic phase, followed by the outcome prognosis, using text data from diagnostic reports and in many cases annotations on medical images. The most frequent approach was based on general machine learning techniques applied to the results of relatively simple NLP methods with the support of ontologies and standard vocabularies. Although smaller in number, there has been an increasing body of studies using deep learning techniques on numerical and vectorized representations of the texts obtained with more sophisticated NLP tools.

Conclusions
Studies focused on NLP applied to stroke show specific trends that can be compared to the more general application of artificial intelligence to stroke. The purpose of using NLP is often to improve processes in a clinical context rather than to assist in the rehabilitation process. The state of the art in NLP is represented by deep learning architectures, among which Bidirectional Encoder Representations from Transformers has been found to be especially widely used in the medical field in general, and for stroke in particular, with an increasing focus on the processing of annotations on medical images.
Pelatihan dan pendampingan Optimalisasi Menejemen Penganggaran Dan Pelaporan Keuangan SMP Boarding School Aisiyiyah Lawang
Authors: Setu Setyawan  , Ahmad Juanda  
Published: July 2023

Ibm. Optimalisasi Menejemen Anggaran Dan Pelaporan Keuangan SMP Boarding Sechoal Aisiyiyah Lawang. Kab, Malang, memberikan pelatihan penyusuanan rencana anggaran sekolah berbasis kinerja. Rencana Anggaran Pendapatan Belanja Sekolah (RAPBS) berbasis kinerja dapat meberikan informasi tingkat Output yang dihasilkan dengan indikator pengukuran yang sudah distandarkan. Metode pengabdian yang digunakan adalah metode PRA (Participatory Rapid Appraissal) merupakan pengembangan sistem yang mengutamakan kecepatan pengembangan melalui keterlibatan user atau Pengguna dalam penggunaan suatu rangkaian sistem, dimana rangkaian tersebut berfungsi untuk suatu model (prototype) sistem yang lebih efektif. Program pengabdian yang telah dilakukan dengan tahapan pre test dengan menguji tingkat kemampuan dan ketrampilan menguasai konsep penganggaran dan tekhnologi informasi khsusunya program Excel, hal tersebut untuk memberikan model pelatihan yang tepat pada akhir periode pelatihan dilakukan past test dengan hasil nilai pre test rata rata 60 dan setelah pelatihan nilai rata rata meningkat 85. Output yang dihasilkan selama pengabdian telah tersusunnya Prototipy RAPBS berbasis Kinerja dan Sistim Informasi Pengelolaan Keuangan Anggaran (berbasis Excel).
Effect of the Absence of HEMA on the Bonding Properties of Universal Adhesive Systems Containing 10-MDP: An In Vitro Study
Authors: Wendlinger M , Nuñez A , Moreira PHA , Carneiro TS , Cochinski GD , Siqueira FSF , Cardenas AFM , Loguercio AD 
Published: July 2023

SUMMARY

Objectives
To evaluate the absence of 2-hydroxyethyl methacrylate (HEMA) on the adhesive properties with enamel and dentin of universal adhesive systems containing 10-methacryloyloxydecyl dihydrogen phosphate (MDP).

Methods and Materials
One hundred and twelve caries-free third molars were used to test adhesion to dentin (n=64) and enamel (n=48). For each substrate, teeth were divided into eight experimental groups: four different adhesives each using two adhesive strategies. The adhesives used were: (1) Scotchbond Universal (SBU, 3M Oral Care, St Paul, MN, USA) as a HEMA-containing universal adhesive; (2) Gluma Bond Universal (GBU, Kulzer, Hanau, Germany); (3) Solare Universal Bond (SUB, GC, Tokyo, Japan); and (4) Zipbond Universal (ZIP, SDI, Victoria, Australia) as HEMA-free universal adhesives. The adhesive strategies used were etch-and-rinse (ER) and self-etch (SE). For dentin tests, the occlusal third of the crown of all teeth was removed and an adhesive protocol was applied. After completing the restoration, specimens were sectioned into bonded sticks (0.8 mm 2) and tested for microtensile bond strength (μTBS), in situ degree of conversion (DC), and nanoleakage (NL) by scanning electron microscopy. For enamel tests, teeth were sectioned into four parts (buccal, lingual, and proximal), and an adhesive protocol was applied. After completing the restoration, the specimens were tested for their microshear bond strength (μSBS). For in situ degree of conversion (DC) and nanoleakage (NL) evaluation of enamel, the specimens were sectioned in slices to be evaluated. The data for each substrate were subjected to two-way ANOVA and Tukey’s test (α=0.05) for each property evaluated.

Results
The SBU and ZIP adhesives showed the highest μSBS, and DC (dentin and enamel) and lower NL (dentin) values compared to GBU and SUB (p=0.001). However, SBU showed better results in terms of μTBS and μSBS (SE strategy), and DC (dentin and enamel) than ZIP. Strategy ER presented higher values of μTBS and μSBS when compared to strategy SE (p=0.001), except for SBU.

Conclusion
The effect of the absence of HEMA in commercial universal adhesive systems on enamel and dentin adhesive properties appears to be material-dependent.
Biological Features of <i>Tenebrio Molitor</i>, <i>Zophobas Morio</i> and <i>Hermetia Illucens</i> Larvae as the Source of Feed Protein for Animals
Authors: Medvedev A. Y. , Volgina N. V. , Smetankina V. G. , Matkovskaya A. A. , Zelenkov A. P. , Zelenkova G. A. 
Published: July 2023

Introduction. Due to the world’s population growth, the need for food products increases. The only way to solve the problem is to develop the animal husbandry, poultry and fish farming, which are currently facing the acute deficit of protein feedstuff. Due to the chemical composition, the larvae of the yellow mealworm (Tenebrio molitor) beetle, zofobas (Zophobas morio) beetle and the black soldier fly (Hermetia illucens) could be efficiently used in the compound feed production. Therefore, our research aims at the comparative study of the biological features of the above insects and their larvae in the context of improving the technology of the new types of feed protein production.Materials and Methods. The research was conducted by comparing the biological features of the following insects: Tenebrio molitor, Zophobas morio and Hermetia illucens.Results. The specific temperature conditions in the native ranges of the studied insect species were revealed. That could benefit the larvae artificial rearing technology. The aspects of the natural fodder base influence on the formation of the larvae nutrient medium upon their rearing for feed protein production were determined. The larvae growth intensity of the studied insect species was compared.Discussion and Conclusion. The study of Tenebrio molitor, Zophobas morio and Hermetia illucens biological features brought us to the conclusion that using their larvae as feed protein in production of the compound feed is expedient. Based on the chemical composition features of the above larvae, both in their natural and protein feed flour form, they can be recommended for feeding the valuable fish species, poultry, pigs and small domestic animals.