bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kenotic Ecclesiology and the Disestablishment of the Church of England under the Reign of Charles III
Authors: Percy Martyn 
Published: July 2023

AbstractCoronations in Great Britain previously offered an occasion for national civic and spiritual renewal. However, the recent crowning of Charles III threw a spotlight on some of the deepening dissonance, diversity and divisions within British society. This paper is an ‘in principle’ argument for change and development. As the clamour for constitutional reform in the United Kingdom continues, and the awkwardness of Church of England bishops sitting in the House of Lords becomes more apparent, the time is ripe to reconsider disestablishment. In particular, the power and privilege of one denomination over all others is interrogated in relation to a kenotic ecclesiology, and which may now require the intentional divesting of kingly power: not clinging to status any longer, but self-emptying and embracing equality.
Data-efficient human walking speed intent identification
Authors: Higgins Taylor M. , Bresingham Kaitlyn J. , Schmiedeler James P. , Wensing Patrick M. 
Published: July 2023

Abstract
The ability to accurately identify human gait intent is a challenge relevant to the success of many applications in robotics, including, but not limited to, assistive devices. Most existing intent identification approaches, however, are either sensor-specific or use a pattern-recognition approach that requires large amounts of training data. This paper introduces a real-time walking speed intent identification algorithm based on the Mahalanobis distance that requires minimal training data. This data efficiency is enabled by making the simplifying assumption that each time step of walking data is independent of all other time steps. The accuracy of the algorithm was analyzed through human-subject experiments that were conducted using controlled walking speed changes on a treadmill. Experimental results confirm that the model used for intent identification converges quickly (within 5 min of training data). On average, the algorithm successfully detected the change in desired walking speed within one gait cycle and had a maximum of 87% accuracy at responding with the correct intent category of speed up, slow down, or no change. The findings also show that the accuracy of the algorithm improves with the magnitude of the speed change, while speed increases were more easily detected than speed decreases.
Prolyl endopeptidase remodels macrophage function as a novel transcriptional coregulator and inhibits fibrosis
Authors: Lin Shuang-Zhe , Wu Wei-Jie , Cheng Yu-Qing , Zhang Jian-Bin , Jiang Dai-Xi , Ren Tian-Yi , Ding Wen-Jin , Liu Mingxi , Chen Yuan-Wen , Fan Jian-Gao 
Published: July 2023

AbstractMacrophages are immune cells crucial for host defense and homeostasis maintenance, and their dysregulation is involved in multiple pathological conditions, such as liver fibrosis. The transcriptional regulation in macrophage is indispensable for fine-tuning of macrophage functions, but the details have not been fully elucidated. Prolyl endopeptidase (PREP) is a dipeptidyl peptidase with both proteolytic and non-proteolytic functions. In this study, we found that Prep knockout significantly contributed to transcriptomic alterations in quiescent and M1/M2-polarized bone marrow-derived macrophages (BMDMs), as well as aggravated fibrosis in an experimental nonalcoholic steatohepatitis (NASH) model. Mechanistically, PREP predominantly localized to the macrophage nuclei and functioned as a transcriptional coregulator. Using CUT&Tag and co-immunoprecipitation, we found that PREP was mainly distributed in active cis-regulatory genomic regions and physically interacted with the transcription factor PU.1. Among PREP-regulated downstream genes, genes encoding profibrotic cathepsin B and D were overexpressed in BMDMs and fibrotic liver tissue. Our results indicate that PREP in macrophages functions as a transcriptional coregulator that finely tunes macrophage functions, and plays a protective role against liver fibrosis pathogenesis.
Ablation of the deubiquitinase USP15 ameliorates nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Authors: Baek Jung-Hwan , Kim Myung Sup , Jung Hye Ryeon , Hwang Min-Seon , Lee Chan-ho , Han Dai Hoon , Lee Yong-ho , Yi Eugene C. , Im Seung-Soon , Hwang Ilseon , Kim Kyungeun , Chung Joon-Yong , Chun Kyung-Hee 
Published: July 2023

AbstractNonalcoholic fatty liver disease (NAFLD) occurs due to the accumulation of fat in the liver, leading to fatal liver diseases such as nonalcoholic steatohepatitis (NASH) and cirrhosis. Elucidation of the molecular mechanisms underlying NAFLD is critical for its prevention and therapy. Here, we observed that deubiquitinase USP15 expression was upregulated in the livers of mice fed a high-fat diet (HFD) and liver biopsies of patients with NAFLD or NASH. USP15 interacts with lipid-accumulating proteins such as FABPs and perilipins to reduce ubiquitination and increase their protein stability. Furthermore, the severity of NAFLD induced by an HFD and NASH induced by a fructose/palmitate/cholesterol/trans-fat (FPC) diet was significantly ameliorated in hepatocyte-specific USP15 knockout mice. Thus, our findings reveal an unrecognized function of USP15 in the lipid accumulation of livers, which exacerbates NAFLD to NASH by overriding nutrients and inducing inflammation. Therefore, targeting USP15 can be used in the prevention and treatment of NAFLD and NASH.
Association between infant breastfeeding practices and timing of peak height velocity: A nationwide longitudinal survey in Japan
Authors: Higuchi Yousuke , Matsumoto Naomi , Fujiwara Shintaro , Ebuchi Yuki , Furujo Mahoko , Nakamura Kazue , Kubo Toshihide , Yorifuji Takashi 
Published: July 2023

Abstract
Background
Several studies have discovered an association between infant feeding practices and puberty timing; however, most have involved female cohorts. We investigated the association between infant feeding practices and the timing of peak height velocity in boys and girls.

Methods
Data on infant feeding methods and anthropometric measurements were collected from a nationwide Japanese birth cohort study. The age at peak height velocity (APV, years) was estimated and compared. Subsequently, the effects of breastfeeding duration were analyzed.

Results
Of the 13,074 eligible participants, 650, 9455, and 2969 were formula-, mixed-, and exclusively breastfed, respectively. Among girls, the mean APV was significantly later in the mixed-fed (standardized regression coefficient (β): 0.094, 95% confidence interval (CI): 0.004–0.180) and exclusively breastfed (β: 0.150, 95% CI: 0.056–0.250) groups than in the formula-fed group. Among boys, the mean APV was not significantly different among the three groups; however, a sensitivity analysis that excluded preterm birth revealed more significantly delayed APV in the breastfed-only group compared to the formula-fed group. Furthermore, a multiple linear regression model revealed that a longer breastfeeding period was associated with later APV.

Conclusions
Infant breastfeeding practices can affect the timing of peak height velocity in both boys and girls.

Impact

Several studies have discovered an association between infant feeding practices and puberty timing; however, most have involved female cohorts. Age at peak height velocity, derived from longitudinal height measurements, is a useful marker of secondary sexual maturity milestones in boys and girls.

A Japanese birth cohort study revealed that breastfed children had a later age at peak height velocity than their formula-fed counterparts; this was more prominent among girls than boys.

Furthermore, a duration-effect relationship was observed, where longer breastfeeding duration was associated with a later age at peak height velocity.
Network effects of Stanford Neuromodulation Therapy (SNT) in treatment-resistant major depressive disorder: a randomized, controlled trial
Authors: Batail Jean-Marie , Xiao Xiaoqian , Azeez Azeezat , Tischler Claudia , Kratter Ian H. , Bishop James H. , Saggar Manish , Williams Nolan R. 
Published: July 2023

AbstractHere, we investigated the brain functional connectivity (FC) changes following a novel accelerated theta burst stimulation protocol known as Stanford Neuromodulation Therapy (SNT) which demonstrated significant antidepressant efficacy in treatment-resistant depression (TRD). In a sample of 24 patients (12 active and 12 sham), active stimulation was associated with significant pre- and post-treatment modulation of three FC pairs, involving the default mode network (DMN), amygdala, salience network (SN) and striatum. The most robust finding was the SNT effect on amygdala-DMN FC (group*time interaction F(1,22) = 14.89, p < 0.001). This FC change correlated with improvement in depressive symptoms (rho (Spearman) = −0.45, df = 22, p = 0.026). The post-treatment FC pattern showed a change in the direction of the healthy control group and was sustained at the one-month follow-up. These results are consistent with amygdala-DMN connectivity dysfunction as an underlying mechanism of TRD and bring us closer to the goal of developing imaging biomarkers for TMS treatment optimization.Trial registration: ClinicalTrials.gov NCT03068715
What Darwin could not see: island formation and historical sea levels shape genetic divergence and island biogeography in a coastal marine species
Authors: Hirschfeld Maximilian , Barnett Adam , Sheaves Marcus , Dudgeon Christine 
Published: July 2023

AbstractOceanic islands play a central role in the study of evolution and island biogeography. The Galapagos Islands are one of the most studied oceanic archipelagos but research has almost exclusively focused on terrestrial organisms compared to marine species. Here we used the Galapagos bullhead shark (Heterodontus quoyi) and single nucleotide polymorphisms (SNPs) to examine evolutionary processes and their consequences for genetic divergence and island biogeography in a shallow-water marine species without larval dispersal. The sequential separation of individual islands from a central island cluster gradually established different ocean depths between islands that pose barriers to dispersal inH. quoyi. Isolation by resistance analysis suggested that ocean bathymetry and historical sea level fluctuations modified genetic connectivity. These processes resulted in at least three genetic clusters that exhibit low genetic diversity and effective population sizes that scale with island size and the level of geographic isolation. Our results exemplify that island formation and climatic cycles shape genetic divergence and biogeography of coastal marine organisms with limited dispersal comparable to terrestrial taxa. Because similar scenarios exist in oceanic islands around the globe our research provides a new perspective on marine evolution and biogeography with implications for the conservation of island biodiversity.
Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice
Authors: Huang Ziyan , Chung Myung , Tao Kentaro , Watarai Akiyuki , Wang Mu-Yun , Ito Hiroh , Okuyama Teruhiro 
Published: July 2023

AbstractPerception of fear induced by others in danger elicits complex vicarious fear responses and behavioral outputs. In rodents, observing a conspecific receive aversive stimuli leads to escape and freezing behavior. It remains unclear how these behavioral self-states in response to others in fear are neurophysiologically represented. Here, we assess such representations in the ventromedial prefrontal cortex (vmPFC), an essential site for empathy, in an observational fear (OF) paradigm in male mice. We classify the observer mouse’s stereotypic behaviors during OF using a machine-learning approach. Optogenetic inhibition of the vmPFC specifically disrupts OF-induced escape behavior. In vivo Ca2+imaging reveals that vmPFC neural populations represent intermingled information of other- and self-states. Distinct subpopulations are activated and suppressed by others’ fear responses, simultaneously representing self-freezing states. This mixed selectivity requires inputs from the anterior cingulate cortex and the basolateral amygdala to regulate OF-induced escape behavior.
A solution-to-solid conversion chemistry enables ultrafast-charging and long-lived molten salt aluminium batteries
Authors: Meng Jiashen , Yao Xuhui , Hong Xufeng , Zhu Lujun , Xiao Zhitong , Jia Yongfeng , Liu Fang , Song Huimin , Zhao Yunlong , Pang Quanquan 
Published: July 2023

AbstractConventional solid-to-solid conversion-type cathodes in batteries suffer from poor diffusion/reaction kinetics, large volume changes and aggressive structural degradation, particularly for rechargeable aluminium batteries (RABs). Here we report a class of high-capacity redox couples featuring a solution-to-solid conversion chemistry with well-manipulated solubility as cathodes—uniquely allowed by using molten salt electrolytes—that enable fast-charging and long-lived RABs. As a proof-of-concept, we demonstrate a highly reversible redox couple—the highly soluble InCl and the sparingly soluble InCl3—that exhibits a high capacity of about 327 mAh g−1 with negligible cell overpotential of only 35 mV at 1 C rate and 150 °C. The cells show almost no capacity fade over 500 cycles at a 20 C charging rate and can sustain 100 mAh g−1 at 50 C. The fast oxidation kinetics of the solution phase upon initiating the charge enables the cell with ultrafast charging capability, whereas the structure self-healing via re-forming the solution phase at the end of discharge endows the long-term cycling stability. This solution-to-solid mechanism will unlock more multivalent battery cathodes that are attractive in cost but plagued by poor reaction kinetics and short cycle life.
Designing main-group catalysts for low-temperature methane combustion by ozone
Authors: Yasumura Shunsaku , Saita Kenichiro , Miyakage Takumi , Nagai Ken , Kon Kenichi , Toyao Takashi , Maeno Zen , Taketsugu Tetsuya , Shimizu Ken-ichi 
Published: July 2023

AbstractThe catalytic combustion of methane at a low temperature is becoming increasingly key to controlling unburned CH4 emissions from natural gas vehicles and power plants, although the low activity of benchmark platinum-group-metal catalysts hinders its broad application. Based on automated reaction route mapping, we explore main-group elements catalysts containing Si and Al for low-temperature CH4 combustion with ozone. Computational screening of the active site predicts that strong Brønsted acid sites are promising for methane combustion. We experimentally demonstrate that catalysts containing strong Bronsted acid sites exhibit improved CH4 conversion at 250 °C, correlating with the theoretical predictions. The main-group catalyst (proton-type beta zeolite) delivered a reaction rate that is 442 times higher than that of a benchmark catalyst (5 wt% Pd-loaded Al2O3) at 190 °C and exhibits higher tolerance to steam and SO2. Our strategy demonstrates the rational design of earth-abundant catalysts based on automated reaction route mapping.
Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics
Authors: Bootz-Maoz Hadar , Simon Ariel , Del Mare-Roumani Sara , Bennet Yifat , Toister Einat , Romano Hadar , Zheng Danping , Amidror Sivan , Elinav Eran , Yissachar Nissan 
Published: July 2023

AbstractThe intestinal epithelial barrier facilitates homeostatic host–microbiota interactions and immunological tolerance. However, mechanistic dissections of barrier dynamics following luminal stimulation pose a substantial challenge. Here, we describe an ex vivo intestinal permeability assay, X-IPA, for quantitative analysis of gut permeability dynamics at the whole-tissue level. We demonstrate that specific gut microbes and metabolites induce rapid, dose-dependent increases to gut permeability, thus providing a powerful approach for precise investigation of barrier functions.
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection
Authors: Gao Lin , Mathur Vrinda , Tam Sabrina Ka Man , Zhou Xuemeng , Cheung Ming Fung , Chan Lu Yan , Estrada-Gutiérrez Guadalupe , Leung Bo Wah , Moungmaithong Sakita , Wang Chi Chiu , Poon Liona C. , Leung Danny 
Published: July 2023

AbstractDuring pregnancy the maternal–fetal interface plays vital roles in fetal development. Its disruption is frequently found in pregnancy complications. Recent studies show increased incidences of adverse pregnancy outcomes in patients with COVID-19; however, the mechanism remains unclear. Here we analysed the molecular impacts of SARS-CoV-2 infection on the maternal–fetal interface. Generating bulk and single-nucleus transcriptomic and epigenomic profiles from patients with COVID-19 and control samples, we discovered aberrant immune activation and angiogenesis patterns in distinct cells from patients. Surprisingly, retrotransposons were also dysregulated in specific cell types. Notably, reduced enhancer activities of LTR8B elements were functionally linked to the downregulation of pregnancy-specific glycoprotein genes in syncytiotrophoblasts. Our findings revealed that SARS-CoV-2 infection induced substantial changes to the epigenome and transcriptome at the maternal–fetal interface, which may be associated with pregnancy complications.
Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis
Authors: Enkler Ludovic , Szentgyörgyi Viktoria , Pennauer Mirjam , Prescianotto-Baschong Cristina , Riezman Isabelle , Wiesyk Aneta , Avraham Reut Ester , Spiess Martin , Zalckvar Einat , Kucharczyk Roza , Riezman Howard , Spang Anne 
Published: July 2023

AbstractLipid mobilization through fatty acid β-oxidation is a central process essential for energy production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome from where β-oxidation products enter mitochondria and fuel the tricarboxylic acid cycle. Little is known about the physical and metabolic cooperation between these organelles. Here we found that expression of fatty acid transporters and of the rate-limiting enzyme involved in β-oxidation is decreased in cells expressing a hyperactive mutant of the small GTPase Arf1, leading to an accumulation of fatty acids in lipid droplets. Consequently, mitochondria became fragmented and ATP synthesis decreased. Genetic and pharmacological depletion of fatty acids phenocopied thearf1mutant mitochondrial phenotype. Although β-oxidation occurs in both mitochondria and peroxisomes in mammals, Arf1’s role in fatty acid metabolism is conserved. Together, our results indicate that Arf1 integrates metabolism into energy production by regulating fatty acid storage and utilization, and presumably organelle contact sites.
Helicopter-borne RGB orthomosaics and photogrammetric digital elevation models from the MOSAiC Expedition
Authors: Neckel Niklas , Fuchs Niels , Birnbaum Gerit , Hutter Nils , Jutila Arttu , Buth Lena , von Albedyll Luisa , Ricker Robert , Haas Christian 
Published: July 2023

AbstractThe Multidisciplinary Drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition took place between October 2019 and September 2020 giving the rare opportunity to monitor sea-ice properties over a full annual cycle. Here we present 24 high-resolution orthomosaics and 14 photogrammetric digital elevation models of the sea-ice surface around the icebreaker RV Polarstern between March and September 2020. The dataset is based on >34.000 images acquired by a helicopter-borne optical camera system with survey flights covering areas between 1.8 and 96.5 km2 around the vessel. Depending on the flight pattern and altitude of the helicopter, ground resolutions of the orthomosaics range between 0.03 and 0.5 m. By combining the photogrammetric products with contemporaneously acquired airborne laser scanner reflectance measurements selected orthomosaics could be corrected for cloud shadows which facilitates their usage for sea-ice and melt pond classification algorithms. The presented dataset is a valuable data source for the interdisciplinary MOSAiC community building a temporal and spatially resolved baseline to accompany various remote sensing and in situ research projects.
DOSE – Global data set of reported sub-national economic output
Authors: Wenz Leonie , Carr Robert Devon , Kögel Noah , Kotz Maximilian , Kalkuhl Matthias 
Published: July 2023

AbstractMany phenomena of high relevance for economic development such as human capital, geography and climate vary considerably within countries as well as between them. Yet, global data sets of economic output are typically available at the national level only, thereby limiting the accuracy and precision of insights gained through empirical analyses. Recent work has used interpolation and downscaling to yield estimates of sub-national economic output at a global scale, but respective data sets based on official, reported values only are lacking. We here present DOSE — the MCC-PIK Database Of Sub-national Economic Output. DOSE contains harmonised data on reported economic output from 1,661 sub-national regions across 83 countries from 1960 to 2020. To avoid interpolation, values are assembled from numerous statistical agencies, yearbooks and the literature and harmonised for both aggregate and sectoral output. Moreover, we provide temporally- and spatially-consistent data for regional boundaries, enabling matching with geo-spatial data such as climate observations. DOSE provides the opportunity for detailed analyses of economic development at the subnational level, consistent with reported values.
Virtual embodiment in fibromyalgia
Authors: Świdrak Justyna , Arias Ana , de la Calle Edgar Rodriguez , Collado Cruz Antonio , Sanchez-Vives Maria V. 
Published: July 2023

AbstractChronic pain alters the experience of owning a body and leads to disturbances in bodily perception. We tested whether women with fibromyalgia (FM) are receptive to bodily illusions of owning a visible and progressively invisible body in immersive virtual reality (VR), and what modulates this experience. Twenty patients participated in two experimental sessions; each session included two conditions in a counterbalanced order. We found that patients with FM could indeed experience virtual embodiment. Sentiment analysis revealed significantly more positive reactions to the progressively invisible body, yet twice as many patients declared they preferred the illusion of a visible virtual body. A linear mixed model revealed that the strength of embodiment was positively associated with body perception disturbances and negatively associated with FM symptoms intensity. No effect of pain during the VR experience nor interoception awareness on embodiment was found. The results indicated that patients with FM are receptive to virtual bodily illusions and that the impact of the embodiment depends on affective reactions, the level of cognitive body distortions, and the intensity of symptoms. Importantly, there is a large variation among patients which should be considered in future VR-based interventions.