bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing tryptophan:lysine ratios in dried distillers grains with solubles-based diets with and without a dried distillers grains with solubles withdrawal strategy on growth, carcass characteristics, and carcass fat iodine value of growing-finishing pigs
Authors: Spinler Mikayla S , Tolosa Andres F , Gebhardt Jordan T , Tokach Mike D , Goodband Robert D , DeRouchey Joel M , Coble Kyle F , Woodworth Jason C 
Published: July 2023

Abstract
A total of 6,240 finishing pigs (DNA 600 × PIC 1050; initially 22.5 ± 1.00 kg), divided into two groups, were used in a 119 or 120 d study comparing increasing Trp:Lys ratio in diets containing dried distillers grains with solubles (DDGS) or a DDGS withdrawal strategy (removing all DDGS from the last phase before marketing) on growth performance and carcass fat iodine value (IV). Pigs were randomly allotted to one of seven dietary treatments with 30 to 36 pigs per pen and 26 replications per treatment. Diets were fed in four phases, approximately 23 to 44, 44 to 71, 71 to 100, and 100 kg to market. Diets included a control corn–soybean meal-based diet (no DDGS) formulated to a 19% standardized ileal digestibility (SID) Trp:Lys ratio, four diets with 30% DDGS fed in all four phases and formulated to provide SID Trp:Lys ratios of 16%, 19%, 22%, or 25%, and two DDGS withdrawal strategy diets: 19% SID Trp:Lys with 30% DDGS in phases 1 through 3 and then 0% DDGS in phase 4 with either a 19% or 25% Trp:Lys ratio. Overall, body weight (BW), average daily gain (ADG), average daily feed intake (ADFI), and gain:feed ratio (G:F) increased (linear, P &lt; 0.05) as SID Trp:Lys ratio increased in diets with 30% DDGS fed in all phases. Simultaneously, hot carcass weight (quadratic, P = 0.014), carcass yield (quadratic, P = 0.012), and backfat depth (linear, P = 0.040) increased with increasing Trp:Lys ratio. Pigs fed the 19% SID Trp:Lys ratio withdrawal strategy diet had similar ADG and ADFI as those fed the control diet, the 25% Trp:Lys withdrawal diet, or the 30% DDGS diets with 25% Trp:Lys ratio throughout the study. Pigs fed the control diet had decreased (P &lt; 0.05) carcass fat IV compared to pigs fed the DDGS diets throughout the study, with pigs fed the two DDGS withdrawal strategy diets intermediate. In summary, increasing the SID Trp:Lys ratio in diets with 30% DDGS resulted in a linear increase in ADG, ADFI, G:F, and BW but did not influence carcass fat IV, with most of the benefits observed as diets increased from 16% to 19% Trp:Lys. Removing DDGS from the diet in the last period reduced carcass fat IV and increased growth rate during the withdrawal period compared to pigs fed with 30% DDGS throughout, indicating value in a withdrawal strategy.
Safety of Re-dosing Nirsevimab Prior to RSV Season 2 in Children With Heart or Lung Disease
Authors: Domachowske Joseph B , Chang Yue , Atanasova Victoria , Cabañas Fernando , Furuno Kenji , Nguyen Kim A , Banu Irfana , Kubiak Robert J , Leach Amanda , Mankad Vaishali S , Shroff Manish , Takas Therese , Villafana Tonya , Wählby Hamrén Ulrika 
Published: July 2023

Abstract
In children with congenital heart disease and/or chronic lung disease entering their second respiratory syncytial virus (RSV) season, 200 mg nirsevimab had a similar safety profile to that of palivizumab and resulted in nirsevimab serum exposures associated with efficacy in healthy infants, supporting efficacy in this population at risk of severe RSV disease.
Development of a prediction model for head and neck volume reduction by clinical factors, dose–volume histogram parameters and radiomics in head and neck cancer
Authors: Ishizawa Miyu , Tanaka Shohei , Takagi Hisamichi , Kadoya Noriyuki , Sato Kiyokazu , Umezawa Rei , Jingu Keiichi , Takeda Ken 
Published: July 2023

Abstract
In external radiotherapy of head and neck (HN) cancers, the reduction of irradiation accuracy due to HN volume reduction often causes a problem. Adaptive radiotherapy (ART) can effectively solve this problem; however, its application to all cases is impractical because of cost and time. Therefore, finding priority cases is essential. This study aimed to predict patients with HN cancers are more likely to need ART based on a quantitative measure of large HN volume reduction and evaluate model accuracy. The study included 172 cases of patients with HN cancer who received external irradiation. The HN volume was calculated using cone-beam computed tomography (CT) for irradiation-guided radiotherapy for all treatment fractions and classified into two groups: cases with a large reduction in the HN volume and cases without a large reduction. Radiomic features were extracted from the primary gross tumor volume (GTV) and nodal GTV of the planning CT. To develop the prediction model, four feature selection methods and two machine-learning algorithms were tested. Predictive performance was evaluated by the area under the curve (AUC), accuracy, sensitivity and specificity. Predictive performance was the highest for the random forest, with an AUC of 0.662. Furthermore, its accuracy, sensitivity and specificity were 0.692, 0.700 and 0.813, respectively. Selected features included radiomic features of the primary GTV, human papillomavirus in oropharyngeal cancer and the implementation of chemotherapy; thus, these features might be related to HN volume change. Our model suggested the potential to predict ART requirements based on HN volume reduction .
Coal phase-out pledges follow peak coal: evidence from 60 years of growth and decline in coal power capacity worldwide
Authors: Lægreid Ole Martin , Cherp Aleh , Jewell Jessica 
Published: July 2023

Abstract
Transitioning to net-zero carbon emissions requires phasing-out unabated coal power; however, recently it has only been declining in some countries, while it stagnated or even increased in others. Where and under what circumstances, has coal capacity reached its peak and begun to decline? We address this question with an empirical analysis of coal capacity in 56 countries, accounting for 99% of coal generation in the world. The peaks in national coal power have been equally spread per decade since 1970. The peaks are more likely to occur in country-years with high levels of electoral democracy, higher GDP per capita, slower electricity demand growth, and with low levels of political corruption. Normally, peaking coal power preceded rather than followed political coal phase-out pledges, often with long time lags. We conclude that though the cost of coal alternatives are declining and concerns over climate change increasing, coal power does not automatically peak even in situations with low demand growth, aging power plants and high import dependence. A quick and decisive destabilization of coal regimes requires, in addition, having sufficient economic capacities and strong democratic governance.
Gene Expressions Preferentially Influence Cortical Thickness of Human Connectome Project Atlas Parcellated Regions in First-Episode Antipsychotic-Naïve Psychoses
Authors: McGuigan Bridget N , Santini Tales , Keshavan Matcheri S , Prasad Konasale M 
Published: July 2023

AbstractAltered gene expressions may mechanistically link genetic factors with brain morphometric alterations. Existing gene expression studies have examined selected morphometric features using low-resolution atlases in medicated schizophrenia. We examined the relationship of gene expression with cortical thickness (CT), surface area (SA), and gray matter volume (GMV) of first-episode antipsychotic-naïve psychosis patients (FEAP = 85) and 81 controls, hypothesizing that gene expressions often associated with psychosis will differentially associate with different morphometric features. We explored such associations among schizophrenia and non-schizophrenia subgroups within FEAP group compared to controls. We mapped 360 Human Connectome Project atlas-based parcellations on brain MRI on to the publicly available brain gene expression data from the Allen Brain Institute collection. Significantly correlated genes were investigated using ingenuity pathway analysis to elucidate molecular pathways. CT but not SA or GMV correlated with expression of 1137 out of 15 633 genes examined controlling for age, sex, and average CT. Among these ≈19%, ≈39%, and 8% of genes were unique to FEAP, schizophrenia, and non-schizophrenia, respectively. Variants of 10 among these 1137 correlated genes previously showed genome-wide-association with schizophrenia. Molecular pathways associated with CT were axonal guidance and sphingosine pathways (common to FEAP and controls), selected inflammation pathways (unique to FEAP), synaptic modulation (unique to schizophrenia), and telomere extension (common to NSZ and healthy controls). We demonstrate that different sets of genes and molecular pathways may preferentially influence CT in different diagnostic groups. Genes with altered expressions correlating with CT and associated pathways may be targets for pathophysiological investigations and novel treatment designs.
Long-Term Outcomes and Growth Analysis of Costochondral Grafts for Hemifacial Microsomia: 24-Year Experience of a Single Surgeon
Authors: Barrero Carlos E. , Villavisanis Dillan F. , Wietlisbach Larissa E. , Pontell Matthew E. , Wagner Connor S. , Salinero Lauren K. , Swanson Jordan W. , Taylor Jesse A. , Nah Hyun-Duck , Bartlett Scott P. 
Published: July 2023

Background:
Costochondral grafts (CCGs) can be used in mandibular reconstruction of Kaban-Pruzansky IIB/III hemifacial microsomia (HFM). Their growth is variable, occasionally necessitating secondary surgery. This study examined one surgeon’s 24-year experience to better quantify long-term outcomes and surgical care required in CCG reconstruction of HFM mandibles.

Methods:
Serial 3-dimensional computed tomography scans, from preoperative to most recent, were analyzed in patients with a minimum of 4 years of clinical follow-up after CCG reconstruction. Graft/ramus height, length, volume, bilateral mandibular body length, and chin deviation were measured. Changes in measurements were analyzed preoperatively, immediately postoperatively, at the most recent imaging before secondary surgery, and at the most recent imaging overall. Growth rates per measure were calculated using scans after CCG but before secondary surgery.

Results:
Thirteen patients were analyzed. Median (SD) clinical follow-up was 10.0 (5.1) years. One patient developed temporomandibular joint ankylosis secondary to stacked-graft malposition, which was repaired without further complications. CCG reconstruction led to immediate improvement in graft/ramus height (P = 0.03), length (P = 0.002), and volumetric symmetry (P = 0.02). No difference was found between graft and native ramus height (P = 0.4) or length measures (P = 0.5), whereas graft volume and the affected mandibular body grew significantly more slowly. According to the latest imaging, 63% of patients required secondary surgery, including distraction osteogenesis or orthognathic surgery, due to differential graft or hemimandible growth behavior. Based on the most recent clinical follow-up, this proportion increased to 93%.

Conclusions:
CCGs provide significant short-term mandibular and facial symmetry improvement in HFM IIB/III. Long-term analysis reveals frequent undergrowth requiring secondary intervention to promote and maintain symmetry.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
Stress relaxation after low- and high-rate deformation of polyurethanes
Authors: Commins Tom , Siviour Clive R. 
Published: July 2023

Polymers possess a wide range of mechanical behaviours depending upon the temperature and loading rate. An often-overlooked aspect is relaxation, important because it acts over a wide range of time periods and begins as soon as the polymer is loaded. In the research presented, the relaxation behaviour of two polyurethanes (PUs) following deformation was investigated at low-rate, 10
−3
s
−1
, and dynamic, 10
3
s
− 1
, loading rates, with the former exploring temperatures from 20°C to −60°C. These are compared to a predictive Prony series model calibrated using mastercurves produced by applying time-temperature superposition to data obtained using a dynamic mechanical analysis machine. For relaxation after dynamic loading, a recently proposed analysis was used to account for the movement of the bars during relaxation. The model could predict the stress-time response after low-rate deformation to strains of 2%, at all temperatures. As the strains increased, irrecoverable deformation was observed and the model became less accurate. In the dynamic experiments, the model accurately predicted the early stages of relaxation for both PUs but deviated later on. A modification was suggested to account for these observations. Further characterization of the mechanical response under large strain compressive loading is also reported.
Association between job satisfaction and current smoking and change in smoking behavior: a 16‐year longitudinal study in South Korea
Authors: Baek Seong‐Uk , Lee Won‐Tae , Kim Min‐Seok , Lim Myeong‐Hun , Yoon Jin‐Ha , Won Jong‐Uk 
Published: July 2023

AbstractBackground and AimsPrevious studies have found that job satisfaction is closely associated with various health outcomes of workers. Our study measured the association between job satisfaction and current smoking and change in smoking behavior.DesignData from the longitudinal Korea Labor and Income Panel Study (KLIPS) that consist of nationally representative samples were used. The repeated measures analysis was conducted.SettingSouth Korea, 2005–2021.ParticipantsIn total, 21 154 workers in Korea followed from 2005 to 2021 (145 120 observations) were included as study participants.MeasurementsThe main predictor variable, job satisfaction, was assessed using a five‐item general job satisfaction questionnaire. Job satisfaction was classified into ‘dissatisfied’, ‘neutral’ and ‘satisfied’, according to the tertiles of the sum of scores. The outcomes of interest were current smoking and initiation and cessation of smoking in the subsequent year.FindingsCompared with those with a neutral level of job satisfaction, those who reported dissatisfaction with their job had an increased risk of smoking initiation [odds ratio (OR) = 1.11, 95% confidence interval (CI) = 1.01–1.22)]. Workers satisfied with their jobs were associated with a decreased likelihood of current smoking (OR = 0.96, 95% CI = 0.94–0.98) and smoking initiation (OR = 0.90, 95% CI = 0.81–0.99). There was a positive relationship between cumulative years of job dissatisfaction and smoking risk: > 4 years of experiencing job dissatisfaction was positively related to current smoking (OR = 1.14, 95% CI = 1.06–1.24) and smoking initiation (OR = 1.22, 95% CI = 1.00–1.49) and negatively related to smoking cessation (OR = 0.84, 95% CI = 0.72–0.99).ConclusionsIn Korea, job dissatisfaction appears to be associated with an increased risk of smoking initiation.
Towards adaptive and transparent tourism recommendations: A survey
Authors: Leal Fátima , Veloso Bruno , Malheiro Benedita , Burguillo Juan C. 
Published: July 2023

AbstractCrowdsourced data streams are popular and extremely valuable in several domains, namely in tourism. Tourism crowdsourcing platforms rely on past tourist and business inputs to provide tailored recommendations to current users in real time. The continuous, open, dynamic and non‐curated nature of the crowd‐originated data demands specific stream mining techniques to support online profiling, recommendation, change detection and adaptation, explanation and evaluation. The sought techniques must, not only, continuously improve and adapt profiles and models; but must also be transparent, overcome biases, prioritize preferences, master huge data volumes and all in real time. This article surveys the state‐of‐art of adaptive and explainable stream recommendation, extends the taxonomy of explainable recommendations from the offline to the stream‐based scenario, and identifies future research opportunities.
‘Our faces change, but it's always the same story’: Crises of social reproduction among informal recyclers in Buenos Aires, Argentina
Authors: Parizeau Kate 
Published: July 2023

AbstractThis paper investigates the gendered dynamics of informal recycling in Buenos Aires, Argentina at a moment of transition in the governance of this work. I argue that there is a strong gender binary apparent in this type of informal work, and that the public nature of informal recycling can exacerbate the gendered crisis of social reproduction experienced by many women recyclers through inviting interventions into their work. This research is based on an extensive survey of informal recyclers and a series of interviews conducted between 2007 and 2011. In Buenos Aires, women's informal recycling work has had a more collective, social, and domestic image as compared to masculine industrial versions of this work. On average, women had more geographically limited experiences of the city and earned less money than men. Women carrying out social reproduction in public spaces were positioned as both needing assistance and deserving of it. The entwining of work and social reproduction for many women informal workers requires that any interventions to improve their work take into account the particular challenges associated with publicly performing the double burden of labor that they bear.
Human Wharton's jelly‐derived mesenchymal stem cells prevent pregnancy loss in a rat by JAK/STAT‐mediated immunomodulation
Authors: Ding Xiaoying , Wu Rongrong , Jin Beibei , Zhu Chunyu , Zhang Yuquan , Yang Xiaoqing 
Published: July 2023

AbstractAimSpontaneous abortion (SA) is a multiple‐original syndrome with immune imbalance as one of its major risk factors. As Wharton's jelly‐mesenchymal stem cells (WJ‐MSCs) are considered to be able to prevent abortion, this study aims to explore the currently poorly understood underlining molecular signaling pathways and regulatory mechanisms of WJ‐MSCs in pregnancy maintenance.MethodsAbortion mode is established by subcutaneous injection of bromocriptine in rat on day 9 and abortion prevention is achieved by WJ‐MSCs injection via tail vein. WJ‐MSCs were cultured with/without the inhibitors of JAK/STAT or NF‐κB. The uterus was collected on the 14th day of gestation and the rate of embryo absorption was calculated. The expression of Th1/Th2/Th3 cytokines in decidual, placental tissue, and peripheral blood was analyzed.ResultsWJ‐MSCs treatment significantly reduced the abortion rate in bromocriptine‐treated pregnancy such that it was not significantly different from a normal pregnancy. JAK/STAT inhibition abolished pregnancy preserving effects of WJ‐MSCs but NF‐κB inhibition did not. The levels of Th1‐related cytokines and mRNA levels in the bromocriptine abortion model were significantly higher than the normal pregnancy group and ethanol control group, while levels of the Th2‐related cytokines and mRNA levels significantly decreased. WJ‐MSCs transfusion into the abortion model restored cytokine profiles such that they were not significantly different from the normal pregnancy group and ethanol control group. JAK/STAT inhibition of WJ‐MSCs prevented their effect on cytokine and mRNA levels, but NF‐κB inhibition did not.ConclusionsWJ‐MSCs significantly lower the rate of embryo resorption of spontaneous abortion by reducing Th1‐related cytokines while increasing Th2 and Th3‐related cytokines in JAK/STAT‐dependent manner.
Narratives and expert information in agenda‐setting: Experimental evidence on state legislator engagement with artificial intelligence policy
Authors: Schiff Daniel S. , Schiff Kaylyn Jackson 
Published: July 2023

AbstractAre narratives as influential in gaining the attention of policymakers as expert information, including for complex, technical policy domains such as artificial intelligence (AI) policy? This pre‐registered study uses a field experiment to evaluate legislator responsiveness to policy entrepreneur outreach. In partnership with a leading AI think tank, we send more than 7300 U.S. state legislative offices emails about AI policy containing an influence strategy (providing a narrative, expert information, or the organization's background), along with a prominent issue frame about AI (emphasizing technological competition or ethical implications). To assess engagement, we measure link clicks to further resources and webinar registration and attendance. Although AI policy is a highly technical domain, we find that narratives are just as effective as expert information in engaging legislators. Compared to control, expert information and narratives led to 28 and 34 percent increases in policymaker engagement, respectively. Furthermore, higher legislature professionalism and lower state‐level prior AI experience are associated with greater engagement with both narratives and expert information. Finally, we find that policymakers are equally engaged by an ethical framing of AI policy as they are with an economic one. The findings advance efforts to bridge scholarship on policy narratives, policy entrepreneurship, and agenda‐setting.
Using routine health data to evaluate the impact of indoor residual spraying on malaria transmission in Madagascar
Authors: Hilton Emily R , Rabeherisoa Saraha , Ramandimbiarijaona Herizo , Rajaratnam Julie , Belemvire Allison , Kapesa Laurent , Zohdy Sarah , Dentinger Catherine , Gandaho Timothee , Jacob Djenam , Burnett Sarah , Razafinjato Celestin 
Published: July 2023

IntroductionIndoor residual spraying (IRS) and insecticide-treated bed nets (ITNs) are cornerstone malaria prevention methods in Madagascar. This retrospective observational study uses routine data to evaluate the impacts of IRS overall, sustained IRS exposure over multiple years and level of spray coverage (structures sprayed/found) in nine districts where non-pyrethroid IRS was deployed to complement standard pyrethroid ITNs from 2017 to 2020.MethodsMultilevel negative-binomial generalised linear models were fit to estimate the effects of IRS exposure overall, consecutive years of IRS exposure and spray coverage level on monthly all-ages population-adjusted malaria cases confirmed by rapid diagnostic test at the health facility level. The study period extended from July 2016 to June 2021. Facilities with missing data and non-geolocated communes were excluded. Facilities in IRS districts were matched with control facilities by propensity score analysis. Models were controlled for ITN survivorship, mass drug administration coverage, precipitation, enhanced vegetation index, seasonal effects and district. Predicted cases under a counterfactualno IRSscenario and number of cases averted by IRS were estimated using the fitted models.ResultsExposure to IRS overall reduced case incidence by an estimated 30.3% from 165.8 cases per 1000 population (95% CI=139.7 to 196.7) under a counterfactual no IRS scenario, to 114.3 (95% CI=96.5 to 135.3) over 12 months post-IRS campaign in nine districts. A third year of IRS reduced malaria cases 30.9% more than a first year (incidence rate ratio (IRR)=0.578, 95% CI=0.578 to 0.825, p<0.001) and 26.7% more than a second year (IRR=0.733, 95% CI=0.611 to 0.878, p=0.001). There was no significant difference between the first and second year (p>0.05). Coverage of 86%–90% was associated with a 19.7% reduction in incidence (IRR=0.803, 95% CI=0.690 to 0.934, p=0.005) compared with coverage ≤85%, although these results were not robust to sensitivity analysis.ConclusionThis study demonstrates that non-pyrethroid IRS appears to substantially reduce malaria incidence in Madagascar and that sustained implementation of IRS over three years confers additional benefits.