bluuebunny/crossref_metadata_2025_split huggingface dataset:
Notes on the type of Abyssotheres abyssicola (Alcock & Anderson, 1899), and a new record of A. acesticola Komatsu & Ohtsuka, 2009 (Brachyura, Pinnotheridae), from the South China Sea
Authors: Shih Yi-Jia , Mitra Santanu , Ng Peter K. L. 
Published: February 2023

Abstract
The type species of Abyssotheres Manning & Galil, 2000, Pinnoteres abyssicola Alcock & Anderson, 1899, was re-examined to ascertain the veracity of several character states which had been used by the original authors to establish the genus. Komatsu & Ohtsuka (2009) had questioned whether the palp of the third maxilliped only had two articles, with the dactylus absent as reported by Manning & Galil (2000). The type female of the species actually has a dactylus on the third maxilliped palp. In addition, despite earlier statements that the first and second ambulatory legs have the longest dactyli, this is not the case, with the second and third legs possessing the longest dactyli. In addition, A. acesticola Komatsu & Ohtsuka, 2009, is here reported from Tungsha Island in the South China Sea, for the first time.
A new species of Paraphoxus (Amphipoda, Phoxocephalidae) from Jeju Island, Korea
Authors: Shin Myung-Hwa 
Published: February 2023

Abstract
During a scientific survey, a new species of phoxocepalid amphipod, Paraphoxus jejuensis sp. nov., was found in the tidal flat of Jeju Island, Korea. Paraphoxus jejuensis sp. nov. is distinguished from its congeneric species by the following features: the presence of a conical-form of incisor on the right mandible, an expanded and subovate basis of pereopod 5, the presence of a single plumose facial seta on epimeron 2, the presence of a few baso-facial setae on the peduncle of uropod 1, the absence of marginal spines and setae on the rami of uropod 2, and the presence of two subapical spines on each lobe of the telson. This new species is described and illustrated herein.
The Program Director Perspective: Perceptions of PGY5 Residents’ Operative Self-Efficacy and Entrustment
Authors: Jensen Rachel M. , Kearse LaDonna E. , Anand Ananya , Dent Daniel L. , Korndorffer James R. 
Published: February 2023

Introduction A 2020 survey of post-graduate year 5 (PGY5) general surgery residents linked to the American Board of Surgery In-Training Examination (ABSITE) revealed significant deficits in self-efficacy (SE), or personal judgment of one’s ability to complete a task, for 10 commonly performed operations. Identifying whether this deficit is similarly perceived by program directors (PDs) has not been well established. We hypothesized that PDs would perceive higher levels of operative SE compared to PGY5s. Methods A survey was distributed through the Association of Program Directors in Surgery listserv; PDs were queried about their PGY5 residents’ ability to perform the same 10 operations independently and their accuracy of patient assessments and operative plans for components of several core entrustable professional activities (EPAs). Results of this survey were compared to PGY5 residents’ perception of their SE and entrustment based on the 2020 post-ABSITE survey. Chi-squared tests were used for statistical analysis. Results 108 responses were received, representing ∼32% (108/342) of general surgery programs. Perceptions from PDs of PGY5 residents’ operative SE were highly concordant with resident perceptions; no significant differences were observed for 9 of 10 procedures. Both PGY5 residents and PDs perceived adequate levels of entrustment; no significant differences were observed for 6 of 8 EPA components. Conclusions These findings show concordance between PDs and PGY5 residents in their perceptions of operative SE and entrustment. Though both groups perceive adequate levels of entrustment, PDs corroborate the previously described operative SE deficit, illustrating the importance of improved preparation for independent practice.
Percutaneous Coronary Intervention Offers Clinical Benefits to Diabetic Patients With Stable Chronic Total Occlusion
Authors: Yan Yunfeng , Yuan Fei , Liu Xinmin , Luo Taiyang , Feng Xu , Yao Jing , Zhang Mingduo , Gu Feifei , Song Guangyuan , Lyu Shuzheng 
Published: February 2023

Whether percutaneous coronary intervention for chronic total occlusion (CTO-PCI) in diabetic patients offers more benefits compared with initial medical therapy (CTO-MT) is unclear. In this study, diabetic patients with one CTO (clinical manifestations: stable angina or silent ischemia) were enrolled. Consecutively, enrolled patients ( n = 1605) were assigned to different groups: CTO-PCI (1044 [65.0%]) and initial CTO-MT (561 [35%]). After a median follow-up of 44 months, CTO-PCI tended to be superior to initial CTO-MT in major adverse cardiovascular events (adjusted hazard-ratio [aHR]: .81, 95% conference-interval: .65–1.02) and significantly superior in cardiac death (aHR: .58 [.39–.87]) and all-cause death (aHR: .678[.473–.970]). Such superiority mainly attributed to a successful CTO-PCI. CTO-PCI tended to be performed in patients with younger age, good collaterals, left anterior descending branch CTO, and right coronary artery CTO. While, those with left circumflex CTO and severe clinical/angiographic situations were more likely to be assigned to initial CTO-MT. However, none of these variables influenced the benefits of CTO-PCI. Thus, we concluded that for diabetic patients with stable CTO, CTO-PCI (mainly successful CTO-PCI) offered patients survival benefits over initial CTO-MT. These benefits were consistent regardless of clinical/angiographic characteristics.
Adolescent Substance Use Outcomes in Response to Social Consequences of Use: The Role of Empathy
Authors: Winters Drew E. , Massey Suena H. , Sakai Joseph T. 
Published: February 2023

Evidence suggests empathy deficits have a temporal relationship with substance use severity by late adolescence theorized to decrease use via recognition of social consequences. However, this has yet to be tested empirically along with differences in cognitive and affective empathy. Adolescents admitted to substance use treatment ( n = 3382) were followed through treatment and 12 months after treatment. Variable trajectories were fit using growth curve models; and cross-lagged effects of cognitive and affective empathy (interpersonal reactivity index) on response to social consequences of use were tested along with how response to social consequences affected the mean trajectory of substance use. Results indicate higher cognitive empathy predicted greater response to social consequences of use and response to these consequences at the end of treatment predicted a steeper decrease in substance use. This evidence highlights the importance of cognitive empathy for responding to social consequences of use for motivating less adolescent substance use.
Plant-based model for the visual evaluation of electroporated area after irreversible electroporation and its comparison to in-vivo animal data
Authors: Lindelauf Kim. H. K. , Thomas Athul , Baragona Marco , Jouni Ali , Nolte Teresa , Pedersoli Federico , Pfeffer Joachim , Baumann Martin , Maessen Ralph. T. H. , Ritter Andreas 
Published: February 2023

Electroporation (EP) is widely used in medicine, such as cancer treatment, in form of electrochemotherapy or irreversible electroporation (IRE). For EP device testing, living cells or tissue inside a living organism (including animals) are needed. Plant-based models seem to be a promising alternative to substitute animal models in research. The aim of this study is to find a suitable plant-based model for visual evaluation of IRE, and to compare the geometry of electroporated areas with in-vivo animal data. For this purpose, a variety of fruit and vegetables were selected and visually evaluated after 0/1/2/4/6/8/12/16/24 h post-EP. Apple and potato were found to be suitable models as they enabled a visual evaluation of the electroporated area. For these models, the size of the electroporated area was determined after 0/1/2/4/6/8/12/16/24 h. For apples, a well-defined electroporated area was visual within two hours, while in potatoes it reached a plateau after eight hours only. The electroporated area of apple, which showed the fastest visual results was then compared to a retrospectively evaluated swine liver IRE dataset which had been obtained for similar conditions. The electroporated area of the apple and swine liver both showed a spherical geometry of comparable size. For all experiments, the standard protocol for human liver IRE was followed. To conclude, potato and apple were found to be suitable plant-based models for the visual evaluation of electroporated area after irreversible EP, with apple being the best choice for fast visual results. Given the comparable range, the size of the electroporated area of the apple may be promising as a quantitative predictor in animal tissue. Even if plant-based models cannot completely replace animal experiments, they can be used in the early stages of EP device development and testing, decreasing animal experiments to the necessary minimum.
Application of Box Behnken experimental design to analyze the influence mechanism of process parameters on mechanical properties of high-performance thermoplastic composites
Authors: Sudheendra K , Vinodhini Jennifer , Govindaraju M , Bhowmik Shantanu 
Published: February 2023

Composite processing relies heavily on process parameters, which are the key factors that determine the quality of the finished product. In this investigation, carbon fiber (CF)-reinforced polyetherketone (PEK) thermoplastic composites are fabricated through film-fiber stacking and consolidation process. In this method, carbon fabric and polymer film are alternately stacked, and the stacks are then consolidated via compression molding to create a laminate. The mechanical properties of CF/PEK composites are studied in relation to crucial process parameters such as molding temperature, molding pressure, and holding time. To identify the optimal process parameters for CF/PEK fabrication, the tensile and interlaminar shear strengths of these composites were evaluated. Non-linear quadratic equations employing Box-Behnken Design in Response Surface Methodology and validation trials were used to model these features. To obtain the optimal mechanical properties of fabricated composites, the combination of factor ranges was discovered by overlaying contour plots within the practical constraints. The ideal process parameters for achieving maximum mechanical qualities were determined to be around molding temperature of 400°C, a holding period of 60 min, and a molding pressure of 10 bar.
Kaempferol inhibits airway inflammation induced by allergic asthma through NOX4-Mediated autophagy
Authors: Xu Jianfeng , Yu Zhenyu , Li Wei 
Published: February 2023

Background Kaempferol has important medicinal value in the treatment of asthma. However, its mechanism of action has not been fully understood and needs to be explored and studied. Methods A binding activity of kaempferol with nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) was analyzed by molecular docking. Human bronchial epithelial cells (BEAS-2B) were treated with different concentrations (0, 1, 5, 10, 20, 40 μg/mL) of kaempferol to select its suitable concentration. In the transforming growth factor (TGF)-β1-induced BEAS-2B, cells were treated with 20 μg/mL kaempferol or 20 μM GLX35132 (a NOX4 inhibitor) to analyze its effects on NOX4-mediated autophagy. In the ovalbumin (OVA)-induced mice, 20 mg/kg kaempferol or 3.8 mg/kg GLX351322 administration was performed to analyze the therapeutic effects of kaempferol on NOX4-mediated autophagy. An autophagy activator, rapamycin, was used to confirm the mechanism of kaempferol in treatment of allergic asthma. Results A good binding of kaempferol to NOX4 (score = −9.2 kcal/mol) was found. In the TGF-β1-induced BEAS-2B, the NOX4 expression was decreased with kaempferol dose increase. The secretions of IL-25 and IL-33, and the NOX4-mediated autophagy were significantly decreased by kaempferol treatment in the TGF-β1-induced BEAS-2B. In the OVA-challenged mice, kaempferol treatment improved airway inflammation and remodeling through suppressing NOX4-mediated autophagy. The rapamycin treatment clearly hampered the therapeutic effects of kaempferol in the TGF-β1-induced cells and OVA-induced mice. Conclusions This study identifies kaempferol binds NOX4 to perform its functions in the treatment of allergic asthma, providing an effective therapeutic strategy in the further treatment of asthma.
Development of a quantitative method to evaluate the printability parameters of water-based ink using visible and near infrared spectroscopy
Authors: Bai Yongli , Huang Xinguo , Peng Nan , Zhang Shanshan , Zhong Yunfei 
Published: February 2023

Water-based inks are widely used in green packaging and printing. The printability parameters of water-based inks, such as viscosity (alcohol concentration (AC)) and color (toning additive concentration (toning yellow concentration/toning red concentration, TYC/TRC)), can only be controlled manually in many printing companies. The printability parameters of water-based inks with different additives were analyzed using spectral preprocessing, variable selection, and model-building methods with visible and near infrared (vis-NIR) spectral data (380∼980 nm). Model performance was compared using the root mean square error of cross-validation (RMSEC) and the coefficient of determination (R2). The results of the experiment indicate that the viscosity of the water-based inks can be quantitatively predicted using the principal component analysis and back propagation neural network model (PCA-BPNN) combined with Savitzky-Golay (SG) smoothing in the spectral subrange, which is superior to the PLS regression model. The R2c and r2p of the PCA-BPNN model were up to 0.998 and 0.993, and the RMSEC and RMSEP values obtained were 0.21 and 0.34. Similarly, the concentration of toning yellow and toning red can be quantitively predicted using the PCA-BPNN model combined with SG smoothing in the 617∼726 nm spectral range, which is better than iPLS regression model. These results indicate that the use of vis-NIR spectroscopy and chemometrics is a promising strategy, reliable for predicting the printability parameters of water-based inks, and provides the technical basis for subsequent implementation of online inspection.
Comparison of Efficacy of Short-Term Versus Conventional Antibiotic Regimen in Treatment of Neonatal Pyogenic Meningitis
Authors: Mehta Khushboo , Bhatt Shwetal , Parmar Niyati Takhatsinh 
Published: February 2023

Objective Conventional regimen for treating neonatal pyogenic meningitis is parenteral antibiotics for 21 days. We compared efficacy of short-term antibiotic of 14 days to this conventional regimen. Methods A quasi-experimental study was conducted in tertiary care hospital over 11 months. Neonates having birth-weight more than 1.5 kg with pyogenic meningitis were enrolled, and allotted into 2 groups: group A was given antibiotics for 14 days and group B for 21 days. They were monitored during hospital stay, and compared on follow-up on day 28. Primary outcome measure was treatment failure in the form of recurrence of sepsis/meningitis and faltering in growth or developmental milestones. Results The treatment success rate in both groups was 100%, no patient had recurrence. Mean growth in head circumference on day 28 was 1.8 (±0.56) cm in group A and 1.62 (±0.56) cm in group B, P = .15. Mean weight gain was 540 (±230) gm in group A and 470 (±180) gm in group B, P = .13. Mean length gain was 2.51 (±0.95) cm in group A and 2.33 (±0.64) cm in group B, P = .32. On day 28, all patients of group A and B had achieved social smile ( P = 1.0), 34 from group A and 38 from group B achieved gaze fixation ( P = .37), 21 from group A and 18 from group B could hold head steady ( P = 1.0). None developed any sequalae or abnormal otoacoustic emissions. Conclusion Short course of antibiotics for neonatal pyogenic meningitis was as effective as the conventional regimen in neonates with cerebrospinal fluid clearance and clinical improvement by day 7.
Can a Predetermined Grid and Multidisciplinary Consultation Improve the Description of Cleft lip with or Without Cleft Palate?
Authors: Vaillant Claudine Le , Bruand Mariette , Corre Pierre 
Published: February 2023

ObjectiveEvaluate the two-dimensional (2D) ultrasound (US) grid and multidisciplinary consultation (maxillofacial surgeon-sonographer) during prenatal US imaging to improve the sensitivity of prenatal description for cleft lip (CL) with or without alveolar cleft (CLA) or +/- cleft palate (CLP).DesignRetrospective study of children with CL/P in a tertiary children's Hospital.SettingSingle-center cohort study conducted in a tertiary pediatric Hospital.Patients/ParticipantsFifty-nine cases of prenatally diagnosed CL +/-CA or CP between January 2009 and December 2017 were analyzed.Main Outcome MeasuresThe correlation was analyzed between prenatal US and postnatal data with regard to eight 2D US criteria (upper lip, alveolar ridge, median maxillary bud, homolateral nostril subsidence, deviated nasal septum, hard palate, tongue movement, nasal cushion flux) in order to propose them in a grid, as well as the presence of the maxillofacial surgeon during the US examination.ResultsAmong the 38 cases included, the results were considered satisfied for 87%. Sixty five percent of the US criteria were described when the final diagnosis was correct (5.2 criteria) versus (vs) 45% (3.6 criteria); [OR = 2.28; IC95% (1.10-4.75) P = .022 < 0.05]. This study also highlighted a more in-depth description when the maxillofacial surgeon was present with 68% of 2D US criteria fulfilled (5.4 criteria) vs 47.5% (3.8) when the sonographer was alone [OR = 2.32; IC95% (1.34-4.06) P < .001].ConclusionThis US grid with eight criteria has considerably contributed to a more precise prenatal description. In addition, the systematic multidisciplinary consultation seemed to optimize it and lead to better prenatal information on pathology and postnatal surgical techniques.
Racial Differences in C-Reactive Protein, Depression Symptoms, and Social Relationships in Older Adults: A Moderated Network Analysis
Authors: Lee Chiyoung , Min Se Hee 
Published: February 2023

Introduction We introduce moderated network analysis as an integrative approach to assess the moderation effects of race on the relationship between C-reactive protein (CRP) and depression symptoms in older adults. This study further explores how the observed relationships differ adjusting for social relationships. Methods This secondary analysis of cross-sectional data from the National Social Life, Health, and Aging Project (2010–2011) includes 2,880 older adults. We used different depression symptom domains (depressed affect, low positive affect, somatic symptoms, and interpersonal problems) from the Center for Epidemiologic Studies-Depression Scale. Social relationships were assessed with measures of social integration, social support, and social strain. The moderated networks were constructed using the R-package mgm. The racial moderator was coded as White/African American racial groups. Results In the moderated networks of CRP and depression symptoms, CRP–“interpersonal problems” edge was present only among African Americans. CRP–“somatic symptoms” edge was present in both racial groups with equal edge weights. After adjusting for social relationships, the aforementioned patterns remained the same, but the edge weights were attenuated. We additionally observed CRP–social strain and social integration–“depressed affect” edges only in African Americans. Discussion Race may moderate the relationship between the CRP and depression symptoms in older adults and social relationships might be important covariates to consider while analyzing them. This study as an initiation point; future network investigations would benefit from leveraging more contemporary cohorts of older adults, gaining a large sample size with diverse racial/ethnic backgrounds, and important covariates. Several important methodological issues of the current study are addressed.
Bioinformatics Analysis of Next Generation Sequencing Data Identifies Molecular Biomarkers Associated With Type 2 Diabetes Mellitus
Authors: Alur Varun , Raju Varshita , Vastrad Basavaraj , Vastrad Chanabasayya , Kavatagimath Satish , Kotturshetti Shivakumar 
Published: February 2023

Background: Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder. The aim of the present investigation was to identify gene signature specific to T2DM. Methods: The next generation sequencing (NGS) dataset GSE81608 was retrieved from the gene expression omnibus (GEO) database and analyzed to identify the differentially expressed genes (DEGs) between T2DM and normal controls. Then, Gene Ontology (GO) and pathway enrichment analysis, protein-protein interaction (PPI) network, modules, miRNA (micro RNA)-hub gene regulatory network construction and TF (transcription factor)-hub gene regulatory network construction, and topological analysis were performed. Receiver operating characteristic curve (ROC) analysis was also performed to verify the prognostic value of hub genes. Results: A total of 927 DEGs (461 were up regulated and 466 down regulated genes) were identified in T2DM. GO and REACTOME results showed that DEGs mainly enriched in protein metabolic process, establishment of localization, metabolism of proteins, and metabolism. The top centrality hub genes APP, MYH9, TCTN2, USP7, SYNPO, GRB2, HSP90AB1, UBC, HSPA5, and SQSTM1 were screened out as the critical genes. ROC analysis provides prognostic value of hub genes. Conclusion: The potential crucial genes, especially APP, MYH9, TCTN2, USP7, SYNPO, GRB2, HSP90AB1, UBC, HSPA5, and SQSTM1, might be linked with risk of T2DM. Our study provided novel insights of T2DM into genetics, molecular pathogenesis, and novel therapeutic targets.