bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer
Authors: Kitakaze Masatoshi , Fujino Shiki , Miyoshi Norikatsu , Sekido Yuki , Hata Tsuyoshi , Ogino Takayuki , Takahashi Hidekazu , Uemura Mamoru , Mizushima Tsunekazu , Doki Yuichiro , Eguchi Hidetoshi 
Published: February 2023

AbstractApproximately 10% of patients with colorectal cancer with submucosal invasion have lymph node metastasis. Pathological risk factors for lymph node metastasis have varying sensitivities and specificities. To predict the risk of lymph node metastasis, the identification of new risk factors is vital. Tumor-infiltrating T cells have been reported to improve the prognosis of many solid tumors. Therefore, the purpose of this study was to examine the relationship between lymph node metastasis and tumor-infiltrating T cells in patients with colorectal cancer with submucosal invasion. We examined CD8+ tumor-infiltrating T cells level as a risk factor for lymph node metastasis in patients with colorectal cancer with submucosal invasion. Using immunohistochemical staining, we identified CD8 + T cells in surgically resected specimens from 98 patients with SM-CRC. We showed that low CD8+ tumor-infiltrating T cells levels are positively correlated with lymph node metastasis. Furthermore, by combining the number of CD8+ tumor-infiltrating T cell and the number of CD103+ tumor-infiltrating T cells, the results showed a high positive predictive value for lymph node metastasis in cases with low numbers of both types of tumor-infiltrating T cells and a high negative predictive value in cases with high numbers of both types of tumor-infiltrating T cells.
Composition and taste of beef, pork, and duck meat and bioregulatory functions of imidazole dipeptides in meat
Authors: Kajiya Katsuko , Arino Madoka , Koshio Akari , Minami Yuji 
Published: February 2023

AbstractThis study quantified the nutritional components and imidazole dipeptide levels of commercially available meats (beef, pork, and duck), and their effects on taste were quantified via taste recognition devices. Although meat and its products are considered high-risk diets, meat components, such as imidazole dipeptides, exert bioregulatory functions. Further, considering their bioregulatory function, commercial meats’ antioxidant activity and vascular endothelial function were examined. Characteristic variations in nutritional components were observed depending on the type and part of meat analyzed. These components affected the taste and texture of meat. The main imidazole dipeptides detected were anserine (duck meat) and carnosine (beef and pork). Meat with larger quantities of total imidazole dipeptide demonstrated better sensory test results. Therefore, anserine and carnosine effects on taste were determined using a taste recognition device; carnosine alone produced a noticeably bitter taste, whereas adding anserine reduced bitterness and enhanced umami taste. In a few cases, cooking enhanced the quantity of carnosine and/or anserine and their antioxidant activities. We demonstrated the ability of imidazole dipeptides, particularly anserine, to improve nitric oxide production in vascular endothelial cells. This study provides essential information for health-conscious consumers to develop high-quality, functional meat products.
Calibration of spectra in presence of non-stationary background using unsupervised physics-informed deep learning
Authors: Puleio Alessandro , Rossi Riccardo , Gaudio Pasqualino 
Published: February 2023

AbstractCalibration is a key part of the development of a diagnostic. Standard approaches require the setting up of dedicated experiments under controlled conditions in order to find the calibration function that allows one to evaluate the desired information from the raw measurements. Sometimes, such controlled experiments are not possible to perform, and alternative approaches are required. Most of them aim at extracting information by looking at the theoretical expectations, requiring a lot of dedicated work and usually involving that the outputs are extremely dependent on some external factors, such as the scientist experience. This work presents a possible methodology to calibrate data or, more generally, to extract the information from the raw measurements by using a new unsupervised physics-informed deep learning methodology. The algorithm allows to automatically process the data and evaluate the searched information without the need for a supervised training by looking at the theoretical expectations. The method is examined in synthetic cases with increasing difficulties to test its potentialities, and it has been found that such an approach can also be used in very complex behaviours, where human-drive results may have huge uncertainties. Moreover, also an experimental test has been performed to validate its capabilities, but also highlight the limits of this method, which, of course, requires particular attention and a good knowledge of the analysed phenomena. The results are extremely interesting, and this methodology is believed to be applied to several cases where classic calibration and supervised approaches are not accessible.
ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer
Authors: Hata Nanako , Shigeyasu Kunitoshi , Umeda Yuzo , Yano Shuya , Takeda Sho , Yoshida Kazuhiro , Fuji Tomokazu , Yoshida Ryuichi , Yasui Kazuya , Umeda Hibiki , Takahashi Toshiaki , Kondo Yoshitaka , Kishimoto Hiroyuki , Mori Yoshiko , Teraishi Fuminori , Yamamoto Hideki , Michiue Hiroyuki , Nakamura Keiichiro , Tazawa Hiroshi , Fujiwara Toshiyoshi 
Published: February 2023

AbstractAdenosine-to-inosine RNA editing is a process mediated by adenosine deaminases that act on the RNA (ADAR) gene family. It has been discovered recently as an epigenetic modification dysregulated in human cancers. However, the clinical significance of RNA editing in patients with liver metastasis from colorectal cancer (CRC) remains unclear. The current study aimed to systematically and comprehensively investigate the significance of adenosine deaminase acting on RNA 1 (ADAR1) expression status in 83 liver metastatic tissue samples collected from 36 patients with CRC. The ADAR1 expression level was significantly elevated in liver metastatic tissue samples obtained from patients with right-sided, synchronous, or RAS mutant-type CRC. ADAR1-high liver metastasis was significantly correlated with remnant liver recurrence after hepatic metastasectomy. A high ADAR1 expression was a predictive factor of remnant liver recurrence (area under the curve = 0.72). Results showed that the ADAR1 expression level could be a clinically relevant predictive indicator of remnant liver recurrence. Patients with liver metastases who have a high ADAR1 expression requires adjuvant chemotherapy after hepatic metastasectomy.
Time‐sensitive coverage control for non‐holonomic and heterogeneous robots: An extremum seeking framework and application
Authors: Zhang Liang , Deng Jinghui , Zhou Kun , Yu Tao , Song Jun , He Shuping 
Published: February 2023

AbstractThis work addresses a time‐sensitive coverage control problem for multiple non‐holonomic mobile robots. The coverage objective is evaluated by the total arrivial time of robots reaching their dominant clients with the predefined constant but heterogeneous velocities. An extremum‐seeking control framework is proposed, including a numerical optimizer that iteratively produces the optimal waypoints of robots minimizing the total arriving time and a state regulator that drives the robot's positions to the optimal locations under both constraints non‐holonomic kinematic model and the constant‐velocity. An improved K‐means algorithm is first designed to produce the waypoint sequence. A theoretical analysis of the convergence of coverage objectives is provided. Then a fixed‐time state regulator for the robot's angular velocity is derived from regulating robot positions to the desired waypoints within each time step that varies with the heterogeneous traversing velocity and the distance between waypoints. Finally, the results are validated by a virtual robotic simulation platform and the experiment on real robots, showing that the proposed methods can efficiently deploy multiple heterogeneous robots for time‐sensitive services to clients with a discrete distribution. The simulation and experimental code are open‐sourced at https://gitee.com/ahu‐icip/simulation.git.
Comparison between peak values of induction motor currents’ waveforms during nearby three‐phase short‐circuits and results from standardized calculations
Authors: Sorrentino Elmer , Vera Andres 
Published: February 2023

AbstractThis article shows a comparison of peak values of measured and computed waveforms of induction motor currents during nearby three‐phase short circuits with the results from the standardized calculations of those currents. The methods for computing short‐circuit currents according to IEC and ANSI standards are based on phasors at grid frequency, and the correspondent transient result is approximated to a simple sine wave plus a decaying DC component. However, the measured and simulated waveforms are far away from those simple waveforms. Thus, the peak values computed by standardized methods must be obviously different than the peak values of measured and simulated waveforms. It is herein shown that these differences are larger in smaller motors, and it is also shown that standardized methods to compute these motor currents are accurate enough although they are simply based on phasors at grid frequency. On the other hand, the maximum value of the first peak of motor contribution does not necessarily occur at the same time of the maximum first peak of grid contribution. This fact had been rarely mentioned, and an analysis about its influence was not found in the literature. Herein, it is shown that the influence of this point is not very important in the analyzed cases.
A novel robust Volt/Var optimization method based on worst‐case scenarios for distribution network operation
Authors: Ahmadi Mahdi , Salami Abolfazl , Alavi Mohammadhasan 
Published: February 2023

AbstractThe Volt/Var optimization (VVO) problem is used for scheduling the voltage regulation and reactive power compensation equipment in distribution networks to minimize power loss and voltage violation. In order to solve the VVO problem for a forthcoming time horizon, it is necessary to predict some parameters such as load demand and renewable energy production. The prediction of these parameters is always accompanied by uncertainty that robust optimization can be used to solve this concern. This paper presents a scenario‐based robust Volt/Var optimization (RVO) method that significantly reduces the number of scenarios required for the worst‐case approach. Solving the VVO problem with the worst‐case scenarios reduces the computational burden and maintains the voltage security of the distribution network against the severe events. The proposed RVO is formulated based on a mixed‐integer second‐order cone programming (MISOCP) model in which Volt/Var control (VVC) equipment is scheduled over a two‐stage strategy. The proposed method is validated using modified 33‐bus and 69‐bus IEEE test systems. The results demonstrate that the proposed RVO method maintains the network's voltage profile within the acceptable range against uncertainties.
Modelling and simulation of (connected) autonomous vehicles longitudinal driving behavior: A state‐of‐the‐art
Authors: Sadid Hashmatullah , Antoniou Constantinos 
Published: February 2023

AbstractMicroscopic traffic models (MTMs) are widely used for assessing the impacts of (connected) autonomous vehicles ((C)AVs). These models utilize car‐following (CF) and lane‐changing models to replicate the (C)AVs driving behaviors. Numerous studies are being lately published regarding the approximation of the driving behaviors of (C)AVs (especially CF behavior) with many state‐of‐the‐art modelling methods. Still, there is no established CF model to mimic the accurate behavior of (C)AVs. Researchers often utilize existing mathematical CF models as well as limited data‐driven models for (C)AVs modelling. Meanwhile, several studies conduct simulation‐based impact assessments with various key performance indicators (KPIs). Identification of these KPIs is a crucial step for future studies. Hence, this paper presents a comprehensive outlook on different CF models with their adopted parameters for (C)AVs modelling and investigates how and in which aspects might the CF behaviors of (C)AVs are different from human‐driven vehicles. In addition, the recent publications in data‐driven CF models including their methodologies are explicitly discussed. This work also reviews simulation‐based studies with the reported impacts and used KPIs. Finally, in light of the findings of this paper, several future research needs are highlighted.
An improved simplified composite right‐/left‐handed zeroth‐order resonator and its application to design a compact microstrip bandpass filter with enhanced upper stopband
Authors: Yu Yongchang , Ding Mingling , Gong Jianqiang , Li Xin , Zeng Xiangui 
Published: February 2023

AbstractAn improved simplified composite right‐/left‐handed (SCRLH) zeroth‐order resonator (ISZOR) is introduced, comprising two lateral parallel capacitors and a centred T‐type inductor circuit. Starting from the lumped circuit of the ISZOR, its miniature microstrip layout can be generated with on more than three times full‐wave simulations by virtue of the implicit space mapping technique. Multi‐solutions of the microstrip ISZOR with identical fundamental mode are obtained by sweeping key physical and electrical parameters, uncovering the relationship among physical sizes, resonant modes, unloaded quality factors and circuit elements. A three‐pole microstrip Chebyshev bandpass filter (BPF) with ultra‐wide upper stopband is further designed. By choosing the constituent ISZORs with identical base frequency but different higher resonant frequencies and applying the over‐coupled I/O terminals, wideband spurious response suppression in the upper stopband is achieved. The target BPF centers at 3.1 GHz with a relatively bandwidth of 5%, which is optimised through a customised aggressive space mapping iterative process. The optimal BPF layout dimensions are automatically obtained with just a few time‐consuming full‐wave simulations. A prototype measurement shows the BPF features good bandpass selectivity in a simple and easy‐to‐fabricate structure, with a transversal size reduction of more than 65% compared to a former counterpart and a rejection level better than 15 dB over 40.0 GHz.
Personalrecruitment in der Universitätsklinik
Authors: van den Hooven Thomas 
Published: February 2023

ZusammenfassungFür die Umsetzung eines nachhaltigen Personal-Recruitments in der universitären Krankenversorgung sollten die aktuellen Entwicklungen und zugrunde liegenden Dynamiken berücksichtigt werden.
Ein besonderer Fokus wird dabei auf die Auswirkungen der Akquise von internationalen Fachkräften und den Einsatz von Beschäftigten der Arbeitnehmerüberlassung gelegt. Exemplarisch werden
verschiedene nachhaltige Strategien mit dem Schwerpunkt auf Auszubildende, Praxisanleitung und Akademisierung vorgestellt. Außerdem werden diese Einzelprojekte mit dem Magnet Recognition
Program verknüpft. Denn die deutsche Krankenhauslandschaft benötigt dringend einen grundlegenden interprofessionellen Kulturwandel, der die Weichen für eine nachhaltige Verbesserung der
Rahmenbedingungen für Pflegende in Deutschland darstellt.
Role of 68Ga-FAPI-04 PET/CT in the Initial Staging of Esophageal Cancer
Authors: Liu Huipan , Yang Xiao , You Zhouxiang , Hu Zhi , Chen Yue 
Published: February 2023

Abstract
Aim To investigate the clinical value of 68Ga-FAPI-04 PET/CT for initial staging of esophageal cancer.
Methods A total of 44 newly diagnosed patients with esophageal cancer were included in the analysis on the basis of postoperative pathology or clinical and radiologic follow-up.
Results All primary lesions showed increased 68Ga-FAPI-04 uptake, with an SUVmax of 14.92 ± 6.91. A total of 561 lymph nodes were verified by surgery (507) or clinical and radiologic follow-up (54), of which 92 lymph nodes were diagnosed as showing metastases. Seventy-five lymph nodes with metastases showed positive findings on 68Ga-FAPI-04, with a diameter of about 1.06 ± 0.53 cm and SUVmax of 8.10±4.71. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for lymph node metastasis detection were 81.5%, 99.3%, 96.6%, 96.2%, and 96.5%, respectively.
Conclusion 68Ga-FAPI-04 PET/CT showed good diagnostic performance in detecting lymph node metastases of esophageal cancer.
Patterns of Neck Nodal Metastasis from Oral Cavity Carcinoma
Authors: Khunteta Nitin , Makkar Ayush , Badwal Jaspreet Singh , Katta Prakhar , Choudhary Dinesh , Viswanath Mohinder , Malhotra Hemant 
Published: February 2023

Objectives The aim is to study the patterns of lymph node metastasis from various sites in oral cavity cancer and determine the risk factors for metastasis.Materials and Methods It is a prospective observational study. The inclusion criteria were—245 patients of carcinoma buccal mucosa, anterior two-thirds of tongue, hard palate, oral surface of soft palate, floor of mouth, vestibule, and alveolus. The exclusion criteria were—patients who had received preoperative chemotherapy or radiotherapy and patients with recurrent disease.Statistical Methods All data were analyzed using SPSS 18.0 and Graphpad prism 7 software for statistical analysis. Count data have been expressed as percentages (%). The χ 2 test was used for univariate analysis of the risk factors of cervical lymph node metastasis. The odds ratio value (with 95% confidence interval) was used to express the risk of cervical lymph node metastasis. p-Value of <0.05 was considered as the difference with statistical significance.Results The most common site involved was buccal mucosa. Patterned lymph node metastasis was seen in 93.5% cases. Skip metastasis was seen in 4.31% cases. Level I b was the most common site of nodal involvement for all primary subsites of oral cavity cancer. The incidence of positive nodes on histopathological analysis was highest in cases of lower alveolus (63.15%), followed by tongue.Conclusion In our study, patterns of lymph node metastasis for oral cavity cancer were comparable to other studies with large number of subjects. The incidence of skip metastasis or aberrant status was low. On multivariate analysis, depth of invasion of tumor, pathologic grade, pathologic T stage, and morphologic type of growth were found to be independent predictors of risk for metastasis.
Surgical Anatomy of Temporalis Muscle Transfer with Fascia Lata Augmentation for the Reanimation of the Paralyzed Face: A Cadaveric Study
Authors: Zhang Yi , Steinbacher Johannes , Weninger Wolfgang J. , Heber Ulrike M. , Reissig Lukas , Yildiz Erdem , Tzou Chieh-Han J. 
Published: February 2023

Abstract
Background The temporalis muscle flap transfer with fascia lata augmentation (FLA) is a promising method for smile reconstruction after facial palsy. International literature lacks a detailed anatomical analysis of the temporalis muscle (TPM) combined with fascia lata (FL) augmentation. This study aims to describe the muscle's properties and calculate the length of FL needed to perform the temporalis muscle flap transfer with FLA.
Methods Twenty nonembalmed male (m) and female (f) hemifacial cadavers were dissected to investigate the temporalis muscle's anatomy.
Results The calculated minimum length of FL needed is 7.03cm (f) and 5.99cm (m). The length of the harvested tendon is 3.16cm/± 1.32cm (f) and 3.18/± 0.73cm (m). The length of the anterior part of the temporalis muscle (aTPM) is 4.16/± 0.80cm (f) and 5.30/± 0.85cm (m). The length of the posterior part (pTPM) is 5.24/± 1.51cm (f) and 6.62/± 1.03cm (m). The length from the most anterior to the most posterior point (aTPMpTPM) is 8.60/± 0.98cm (f) and 10.18/± 0.79cm (m). The length from the most cranial point to the distal tendon (cTPMdT) is 7.90/± 0.43cm (f) and 9.79/± 1.11cm (m).
Conclusions This study gives basic information about the temporalis muscle and its anatomy to support existing and future surgical procedures in their performance. The recommended minimum length of FL to perform a temporalis muscle transfer with FLA is 7.03cm for female and 5.99cm for male, and minimum width of 3 cm. We recommend harvesting some extra centimeters to allow adjusting afterward.
Reversible Cerebral Vasoconstriction Syndrome with Intracerebral Hemorrhage in a Thalassemic Child—An Extremely Rare Complication
Authors: Das Suman , Biswas Atanu , Roy Uma Sinha , Ray Biman Kanti 
Published: February 2023

AbstractA 6-year-old known thalassemic boy presented with a posttransfusional thunderclap headache. A computed tomography scan showed left occipital lobar bleed and magnetic resonance angiography showed diffuse cerebral vasoconstriction, which resolved after 3 months, suggesting reversible cerebral vasoconstriction syndrome. He was treated with oral nimodipine for 3 months and had an excellent recovery without sequelae. To the best of the authors' knowledge, the index case is the first reported case of reversible cerebral vasoconstriction syndrome in a thalassemic child.
Assessment of surface recombination in mid-wave infrared InAsSb nBn detectors using transient microwave reflectance
Authors: Arquitola A. M. , Jung H. , Lee S. , Ronningen T. J. , Krishna S. 
Published: February 2023

Investigation of surface recombination is an important area for infrared detectors as the demand for smaller pixels increases. In this study, we use transient microwave reflectance to characterize the minority carrier lifetime of InAsSb nBn structures under three conditions: As-Grown, blanket Barrier-Etched, and SU-8 Passivated blanket barrier-etched. A qualitative comparison of these three samples shows that the minority carrier lifetime decreases for the Barrier-Etched sample compared to the As-Grown sample, indicating that the minority carrier lifetime is sensitive to changes in the sample surface, specifically the introduction of surface states. We compare these samples quantitatively using a polynomial fit (A−1 + Bn + Cn2). We find for the As-Grown sample A = 1.22 ± 0.45 µs, B = 2.5 ± 0.2 × 10−12 cm3/s, and C = 5.004 ± 4.996 × 10−31 cm6/s, for the Barrier-Etched sample A = 1.17 ± 0.40 µs, B = 9.9 ± 0.2 × 10−12 cm3/s, and C = 9.502 ± 9.498 × 10−30 cm6/s, and for the Passivated sample A = 1.34 ± 0.45 µs, B = 5.3 ± 0.5 × 10−12 cm3/s, and C = 5.500 ± 4.500 × 10−33 cm6/s.
On the magnetic and magnetocaloric properties of rare earth intermetallic compound Tb0.33Ho0.33Er0.33Ni
Authors: Mohapatra Abhaya Prasada , Arout Chelvane J. , Morozkin A. V. , Ramaprabhu S. , Nirmala R. 
Published: February 2023

Polycrystalline rare earth intermetallic compound Tb0.33Ho0.33Er0.33Ni has been synthesized by arc melting under argon atmosphere. Powder X-ray diffraction data suggest that the compound Tb0.33Ho0.33Er0.33Ni crystallizes in orthorhombic structure at 300 K (FeB-type, space group Pnma). Temperature variation of magnetization reveals paramagnetic to ferromagnetic cross-over around 59 K (TC). The TC is close to the average value of the ferromagnetic transition temperatures of TbNi, HoNi and ErNi compounds. Isothermal magnetization has been measured as a function of magnetic field up to 70 kOe and the magnetocaloric effect around TC has been calculated.