bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-center international study to evaluate the safety, functional and oncological outcomes of Irreversible Electroporation for the ablation of prostate cancer
Authors: Zhang Kai , Stricker Phillip , Lohr Martin , Stehling Michael , Suberville Michel , Cussenot Olivier , Lunelli Luca , Ng Chi Fai , Teoh Jeremy , Laguna Pilar , Rosette Jean De La 
Published: September 2023

Abstract
BACKGROUND Irreversible electroporation (IRE) is a novel technique to treat localized prostate cancer with the aim of achieving oncological control while reducing related side effects. We present the outcomes of localized prostate cancer treated with IRE from a multi-center prospective registry.METHODS Men with histologically confirmed prostate cancer were recruited to receive IRE. All the patients underwent prostate biopsy at 1-year post-IRE ablation. The functional outcomes were measured by the International Prostate Symptom Score (IPSS) and International Index of Erectile Function (IIEF-5) questionnaires. The safety of IRE was graded by the treatment-related adverse events (AEs) according to the Common Terminology Criteria for Adverse Events (CTCAE).RESULTS 411 patients were recruited in this study from July 2015 to April 2020. The median follow-up time was 24 months (IQR 15–36). 116 patients underwent repeat prostate biopsy during 12–18 months after IRE. Clinically significant prostate cancer (Gleason ≥ 3 + 4) was detected in 24.1% (28/116) of the patients; any grade prostate cancers were found in 59.5% (69/116) of the patients. The IPSS score increased significantly from 7.1 to 8.2 (p = 0.015) at 3 months but decreased to 6.1 at 6 months (p = 0.017). Afterwards, the IPSS level remained stable during follow-up. The IIEF-5 score decreased at 3 months from 16.0 to 12.1 (p < 0.001) and then maintained equable afterwards. The rate of AEs was 1.8% at 3 months and then dropped to less than 1% at 6 months and remained stable until 48 months after IRE. Major AEs (Grade 3 or above) were rare.CONCLUSION For men with localized prostate cancer, IRE could achieve good urinary and sexual function outcomes and a reasonable oncological result. The real-world data are consistent with earlier studies, including recently published randomized controlled studies. The long-term oncological results need further investigation and follow-up.
Costs and Scale-Up Costs of Community-Based HIV Self-Testing for Female Sex Workers and Men Who have Sex with Men in Jakarta and Bali, Indonesia
Authors: Putri Wayan Citra Wulan Sucipta , Ulandari Luh Putu Sinthya , Valerie Ivy Cerelia , Prabowo Bagus Rahmat , Hardiawan Donny , Sihaloho Estro Dariatno , Relaksana Riki , Wardhani Brigitta Dhyah Kunthi , Harjana Ngakan Putu Anom , Nugrahani Nur Wulan , Siregar Adiatma Yudistira Manogar , Januraga Pande Putu 
Published: September 2023

Abstract
Background.
The proportion of individuals who know their HIV status in Indonesia (66% in 2021) still remains far below the first 95% of UNAIDS 2030 target and were much lower in certain Key Populations (KPs) particularly Female Sex Workers (FSW) and Male having Sex with Male (MSM). Indonesia has implemented HIV Self-testing through Community-based screening (HIV CBS) in addition to other testing modalities aimed at hard-to-reach KPs, but the implementation cost is still not analysed. This study provides the cost and scale up cost estimation of HIV CBS in Jakarta and Bali, Indonesia.
Methods.
We estimated the societal cost of HIV CBS that was implemented through NGOs. The HIV CBS’s total and unit cost were estimated from HIV CBS outcome, health care system cost and client costs. Cost data were presented by input, KPs and areas. Health care system cost inputs were categorized into capital and recurrent cost both in start-up and implementation phases. Client costs were categorized as direct medical, direct non-medical cost and indirect costs. Sensitivity and scenario analyses for scale up were performed..
Results.
In total, 5350 and 1401 HIVST test kits were distributed for HIV CBS in Jakarta and Bali, respectively. Average total client cost for HIV CBS Self testing process ranged from US$1.9 to US$12.2 for 1 day and US$2.02 to US$33.61 for 2 days process. Average total client cost for HIV CBS confirmation test ranged from US$2.83 to US$18.01. From Societal Perspective, the cost per HIVST kit distributed were US$98.59 and US$40.37 for FSW and MSM in Jakarta andUS$35.26 and US$43.31 for FSW and MSM in Bali.
Conclusions.
CBS using HIVST approach varied widely along with characteristics of HIV CBS volume and cost. HIV CBS was most costly among FSW in Jakarta, attributed to the low HIV CBS volume, high personnel salary cost and client cost. Future approaches to minimize cost and/or maximize testing coverage could include unpaid community led distribution to reach end-users, integrating HIVST into routine clinical services via direct or secondary distribution and using social media network.
Elevated Tryptase Level in a Child with Idiopathic Anaphylaxis: A Case of Hereditary Alpha-Tryptasemia
Authors: Blanc Vicky Le 
Published: September 2023

Abstract
Hereditary Alpha-Tryptasemia (HαT) is an autosomal dominant disorder estimated to affect 5% of the population. High baseline tryptase level is a consistent finding, but there is a great variability of clinic manifestations, including no symptoms at all. We describe a case of HαT in a 5 years 8 months old girl manifesting with idiopathic anaphylaxis and elevated baseline tryptase level. As more cases of HαT are described, a better understanding of the clinical phenotype will be acquired.
Determinants of the use of public healthcare facilities for primary care of diabetes and hypertension in Urban Mysuru, India: a mixed-methods cross-sectional study 2022.
Authors: Verma Veenapani Rajeev , Ilangovan Kumaravel , Selvam Sumithra , Patil Gururaj , Kowlgi Ambuja , Malve Vidyacharan , Rajanna Yogendra Dommasandra , Chandrashekhar Sudha , DG Nagaraju , N Swaroop 
Published: September 2023

Abstract

Background
Noncommunicable diseases (NCDs) are one of the leading causes of morbidity and mortality in India. This study aimed to ascertain the individual, household, community, and health systems level factors influencing the demand of public healthcare network for primary management of diabetes and hypertension in a city in South India.
Methods
A mixed-methods cross-sectional study was conducted in Mysuru City, Karnataka. For quantitative inquiry, three-stage sampling strategies were followed and interviewed 6007 households comprising 2078/11978 (17.3%) individuals aged 30 and above with known diabetes or hypertension using structured questionnaires and different hierarchical levels of the workforce at 23 urban public health facilities. Andersen’s Behavioural Model of Healthcare Utilization, Multivariate logistic regression and Erreyger’s concentration indices were employed to unravel the socio-economic-demographic and contextual determinants driving the utilization of either public or private healthcare facilities for primary care of Diabetes and Hypertension. For Qualitative inquiry, we used multifarious techniques, such as a) four Key Informant Interviews (KII) conducted with policymakers at the state and city level with the help of semi-structured interview guides, b) 12 focus group discussions (FGDs) conducted with a homogenous group of respondents (men and women with diabetes and hypertension, frontline health workers and c) 36 In-depth Interviews (IDIs) d) 04 Public engagement workshops.
Results
The prevalence of diabetes and hypertension was greater in females (52.9% and 57.4%, respectively). More than two-thirds of surveyed population (68.4% and 64.6%) sought care for diabetes and hypertension from heterogeneous private providers. Socio-structural factors such as the level of education, occupation status, religion and caste, and individual characteristics such as living standards and insurance coverage (inverse and direct relationship, respectively) and facilities having high-technical and process quality scores and absence of multimorbidity impacted the likelihood of utilization of the public health system for management of diabetes and hypertension care. Erreyger's Indices established the inequality in access to public health facilities for treatments for both diabetes and hypertension among the poor.
Conclusion
The findings revealed a pervasive gap in the utilization of public health facilities for management of NCDs, by the urban poor despite the financial burden to seek care from private providers. Various demand and supply side recommendations can be propounded to augment the coverage and quality of public facilities for NCD management.
Comparison of Biomechanical Behavior Between Commercial and Patient-Specific TI6AL4V Titanium Plates of the Same Design Following Le Fort I Osteotomy: A 3D- Finite Element Analysis
Authors: Telha wael , Wang Qi , Al-Watary Mohammed Qasem , Sakran Karim , Chen Haozhe , Zhu Songsong , Jiang Nan 
Published: September 2023

AbstractBackground:Le Fort I osteotomy is a common orthognathic procedure for treating patients with midface skeletal abnormalities. This study evaluates and compares the biomechanical behavior between the three-dimensional (3D) printed patient-personalized TI6AL4V mini plates with commercially made pure mini plates of the same size and design using finite element analysis.Methods:Le Fort I osteotomy with 5 mm advancement associated with mediolateral rotation of the maxilla on the sagittal plane creating a gap of 3 mm at the most posterior part of the left side model was virtually executed on 3D-model using Mimics software. Fixation methods were modeled using (software) to represent 3D-printed patient-personalized TI6AL4V and commercially titanium mini plates. Both fixation mini plates models had the same conventional 4-hole L-shape design with similar thicknesses of 0.5 mm and 0.7 mm and placement vectors at the piriform rims and the zygomaticomaxillary buttress, respectively. ANSYS R19.2 software (Canonsburg, Pennsylvania, U.S.) was employed to create computer-aided engineering finite element models and analyses. Stress distribution, strain behaviors, and displacements of the fixation mini-plates, total model, and the maxilla segment were analyzed after loading postoperative occlusal force of 125, 250 and 500 N/mm².Results:Le Fort I fixation with TI6AL4V L-shaped mini plates resulted in lower principal VM stress, strain, and displacement values than commercially made titanium L-shaped mini plates. The TI6AL4V fixation demonstrated a reduced displacement of the maxillary segment. Both fixation models showed the maximum VM stress, strain, and displacement values across the area where a vertical gap between the bony segment of the maxilla was created due to the downward rotation creating a posterior gap of 3mm at the left side of the maxilla. The maximum overall VM stresses of TI6AL4V mini plates were relatively higher than those observed in the commercial titanium mini plates.Conclusion:The maximum stress, strain, and segment displacement of both fixation models were predominantly concentrated in the area of the vertical gap. Notably, both fixation materials exhibited remarkably close values, which can be attributed to the similar design of the fixation plates used in both models.
The detection of amyloid-β peptides in gingival crevicular fluid and its influence on oral pathogens
Authors: Liao Yue , Chen Huiwen , Qiu Che , Shen Hui , He Zhiyan , Song Zhongchen , Zhou Wei 
Published: September 2023

Abstract
Objective Periodontitis is the most prevalent oral inflammatory disease, contributing to the onset and progression of Alzheimer’s disease. However, the expression level of amyloid-β (Aβ) peptide in gingival crevicular fluid (GCF) and its effects on oral pathogens have not been studied adequately. This study aimed to analyze the expression level of Aβ peptides in GCF of periodontitis patients and the effects of Aβ peptides against common oral pathogens.Methods GCF samples were collected from patients with periodontitis (n = 15) and periodontally healthy people (n = 10). Four common oral pathogenic strains were used to evaluate the antibacterial effect of Aβ peptides via an MTT assay, Crystal Violet Staining, fluorescence microscope, and transmission electron microscope.Results The protein level of Aβ40 and Aβ42 in the GCF of periodontitis group was up-regulated compared with the healthy group. Both Aβ40 and Aβ42 exhibited antibacterial effects on Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Lactobacillus acidophilus in both planktonic and biofilm conditions. Further, Aβ40 showed an antibacterial effect on the biofilm of Fusobacterium nucleatum.Conclusions This study's findings demonstrate that Aβ peptides in GCF could be an indicator associated with the status of periodontitis. Further, the antimicrobial peptides derived from Aβ peptides have great potential in periodontal therapy.
Numerical analysis of brittle strength of welded pipelines with corrosion metal loss in transportation of blends of natural gas with hydrogen
Authors: Milenin Alexey , Velikoivanenko Elena , Rozynka Galina , Pivtorak Nina 
Published: September 2023

Abstract
As part of the analysis of the possibility of using the Ukrainian gas transportation system for transporting blends of natural gas and hydrogen, the peculiarities of the influence of hydrogen degradation of pipe steel on the brittle strength of girth welds and local corrosion metal losses were considered. For this, they were used the methods of finite-element modeling of the stress-strain state of structures during welding and subsequent operation loading along with advanced criteria of macroscopic fracture of a body with a crack. The results of predicting the safety factor for a typical welded part of a main gas pipeline with postulated surface cracks during the transportation of gas-hydrogen blends of various compositions showed that the most susceptible to brittle fracture are the weld metal and heat affected zone. But with regard to the fatigue strength of welded joints under the action of cyclic loading by internal pressure or bending moment, larger stress intensity factor ranges in the heat affected zone cause a more significant reduction of the residual safety factors. Local corrosion damage during the transportation of gas-hydrogen blends had a considerable negative impact on pipeline reliability, particularly when material properties experienced hydrogen degradation and a decrease in fracture toughness. However, this effect could be mitigated by adjusting the operating load accordingly.
Iron Metabolism-Related Gene Signatures for Predicting the Prognosis of Patients With Diffuse Large B-cell Lymphoma
Authors: Zhang Yuxin , Wang Yue , Cui Dawei , Wei Zheng 
Published: September 2023

Abstract
Background
Diffuse large B-cell lymphoma (DLBCL) is a common and highly aggressive type of lymphoma. Iron metabolism plays a critical role in various diseases, however, which remains completely unclear in patients with DLBCL. The aim is to explore the genetic characteristics and molecular mechanisms underlying iron metabolism in patients with DLBCL.
Methods
Based on the Gene Expression Omnibus (GEO) and the GeneCards database, weighted gene co-expression network analysis (WGCNA)was performed on the DLBCL sample (GSE83632) and Iron metabolism-related datasets to establish the gene co-expression network. Enrichment analysis was used to screen the key gene and analyze its expression and possible mechanism of action in patients with DLBCL.
Results
GATA1 was a key gene of iron metabolism in patients with DLBCL. It was related to the myeloid cell differentiation and granulocyte differentiation pathways to affect CD4 + T cells, B cells, and monocytes. GATA1 was also strongly positively correlated with sensitivity to multiple targeted drugs, like imatinib, nilotinib, and crizotinib, but negatively correlated with the PI3K inhibitor, and CDK9 inhibitor. The group with high GATA1 expression had higher overall survival and better prognosis than the group with low expression.
Conclusions
GATA1 is the first time to reveal the molecular mechanisms underlying the relationship between iron metabolism and DLBCL, suggesting that GATA1 is a significant biological target and immune-related biomarker of DLBCL.
The Variations in the Phytochemical Attributes of Nerium Oleander, Ricinus Communis, Calotropis Procera and Withania Somnifera From Three Ecological Zones of Pakistan
Authors: Khilji Sheza Ayaz , Tazeen Khola , Sajid Zahoor Ahmad , Akbar Khalid Farooq 
Published: September 2023

Abstract

The phyto-climatic diversity in a region presents the life form of vegetation. Plants produce vast and diverse variety of phytochemicals to communicate and minimize the climatic threats. In the current study, the variations in the phytochemical attributes of four plant species (Nerium oleander, Ricinus communis, Calotropis procera and Withania somnifera) from three ecological zones of Pakistan (sandy desert, irrigated & rain-fed plains) were investigated. The phenolic acids, flavonoids and tannins were quantitatively analyzed by methanolic extraction and standardized methods. The results revealed that zone rainfed lands and zone sandy desert showed the maximum amount of phytochemicals in all species and also exhibited the extreme environmental conditions. The irrigated plains had less stressful environmental condition and maximum amount of soil organic matter that resulted in minimum amount of phytochemicals in plant species. Previous research also supports the evidence that environmental stresses like temperature stresses, water stresses, high light intensities increase, and organic matter hinders the accumulation of phytochemicals. This study proved that same species in different ecological zones show different amounts of phytochemicals due to environmental variations, although environmental stresses exert the effects on plants to produce more phytochemicals.
Preoperative thrombocytosis is a predictor of poor prognosis in patients with resectable non-small-cell lung cancer: a retrospective randomized controlled study
Authors: wang bin , li zhupeng , zhu ting , ding Jianyi , zhang Jiandong , zhao junjun , yu guangmao , wang haiyong 
Published: September 2023

Abstract

Background:Operable non-small-cell lung cancer (NSCLC) has highly variable biological behavior. Blood markers cannot accurately predict its prognosis. Previous studies have shown that preoperative thrombocytosis is associated with poor prognosis in several cancers. The purpose of this study is to evaluate the prognostic significance of preoperative thrombocytosis in patients with NSCLC.Methods:We conducted a retrospective study on patients with NSCLC who underwent radical resection from May 2016 to December 2017. Platelet count was measured before each operation to evaluate the relationship between platelet count and clinicopathological factors and prognosis.Results:compared with patients with normal platelet count, patients with elevated platelet count had an increased risk of disease progression and death. The hazard ratio for disease progression was 1.585 (95% [CI] 1.159–2.166, P = 0.001), and the ratio for death was 1.385 (95% [CI] 1.041–1.843, P = 0.025).
Hydrogeochemistry and genesis of metasilicate spring water in the Changbai Mountain basalt area,NE
Authors: Su Yujuan , Yang Fengtian , Liang Xiujuan , Xiao Changlai 
Published: September 2023

Abstract
There have been many volcanic activities in the basalt area of Changbai Mountain, NE China is abundant in metasilicate spring water due to its unique geological conditions. This study analyzed the hydrochemical characteristics and genesis of the spring water based on analyses of water chemistry, water isotopes, SF6 and lithology of the volcanic rocks. Results show that the spring water is mainly recharged by local precipitation, with an elevation of 430.3-1033.5 m, then run along water conductive faults and discharges at low-lying areas as springs. The circulation depth of the groundwater is about 13–169 m, which is less than the thickness of the whole basalt layer, indicating that the groundwater circulation is limited to the basalt layer. The SF6 age of the spring water is around 8.5-35.0 a, indicating a rather fast flow rate. The main hydrochemical facies of the spring water is HCO3–Ca·Mg·Na, followed by HCO3–Na·Mg·Ca and HCO3–Mg·Na·Ca.Based on cross-plots of main chemical components, Pearson Correlation and Principle Component Analysis (PCA), the origin of the solutes in the groundwater and the main water-rock interactions are identified.
K2FeO4 modified biochar promotes the improvement of acid soil properties and the fixation of heavy metal ions in copper mines.
Authors: Zhang Xiao , Xue Jinchun , Han Huaqin , Wang Yu 
Published: September 2023

Abstract
A series of environmental pollution problems will occur in the process of copper sulfide mining, especially the acidification of mineral soil. In this study, a K2FeO4-biochar (Fe-BC) system was constructed by modifying biochar. Taking copper sulfide polluted acidic soil as the research object, aiming at the problems of low pH value, excessive heavy metals and insufficient organic matter content in soil, the organic-inorganic collaborative improvement method was adopted based on soil culture experiment. Under Fe-biochar system, the composite soil amendment has excellent effect on the improvement of mine soil characteristics polluted by Pb, Cu and Zn, and the fixation ability of heavy metal ions is enhanced. Fe-BC adsorption effect on Cu2+ Due to the original biochar (BC), the adsorption capacity increased by 44.96%. The quasi-second-order kinetic model and Langmuir model fit well (R2>0.98), indicating that the adsorption of Cu2+ is mainly monolayer surface adsorption and chemical adsorption. The surface properties and pore structure of Fe-BC before and after adsorption were characterized by Scanning Electron Microscope-Energy Dispersive Spectroscopy, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. It was found that ferrate biochar has pore diffusion, electrostatic and complexation mechanisms on heavy metals, enhanced the solidification of heavy metals through reduction reaction.
The size effect and analogous boundary states in a periodic non-Hermitian chain
Authors: Ma Xin-Yu , Li Qiao-Nan , Guan Yi-Han , Qi Lu , He Ai-Lei 
Published: September 2023

Abstract
We investigate the size effect and boundary states based on a periodic non-Hermitian chain under the nonreciprocal intra-cell coupling and inter-cell coupling regimes. We find that the periodic non-Hermitian chain exhibits an even-odd effect of the unit cell corresponding to a large size of the chain, which is different from the open non-Hermitian chain only exhibiting the same effect for a small size of the chain. Moreover, we find that the originally localized bulk states become totally extended via designing the periodic coupling strength appropriately. The extended bulk states reveal the fact of the disappearance of non-Hermitian skin effect. Specially, we show that the periodic non-Hermitian chain also possesses the analogous edge states under some parameter regimes, which is pretty counterintuitive since the periodic chain usually cannot define a boundary. Our investigations supply the different non-Hermitian phenomena in a periodic non-Hermitian chain.