bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the pooled cohort equations and coronary artery calcium scores in a symptomatic mixed Asian cohort
Authors: Baskaran Lohendran , Lee Jing Kai , Ko Michelle Shi Min , Al’Aref Subhi J. , Neo Yu Pei , Ho Jien Sze , Huang Weiting , Yoon Yeonyee Elizabeth , Han Donghee , Nakanishi Rine , Tan Swee Yaw , Al-Mallah Mouaz , Budoff Matthew J. , Shaw Leslee J. 
Published: January 2023

BackgroundThe value of pooled cohort equations (PCE) as a predictor of major adverse cardiovascular events (MACE) is poorly established among symptomatic patients. Coronary artery calcium (CAC) assessment further improves risk prediction, but non-Western studies are lacking. This study aims to compare PCE and CAC scores within a symptomatic mixed Asian cohort, and to evaluate the incremental value of CAC in predicting MACE, as well as in subgroups based on statin use.MethodsConsecutive patients with stable chest pain who underwent cardiac computed tomography were recruited. Logistic regression was performed to determine the association between risk factors and MACE. Cohort and statin-use subgroup comparisons were done for PCE against Agatston score in predicting MACE.ResultsOf 501 patients included, mean (SD) age was 53.7 (10.8) years, mean follow-up period was 4.64 (0.66) years, 43.5% were female, 48.3% used statins, and 50.0% had no CAC. MI occurred in 8 subjects while 9 subjects underwent revascularization. In the general cohort, age, presence of CAC, and ln(Volume) (OR = 1.05, 7.95, and 1.44, respectively) as well as age and PCE score for the CAC = 0 subgroup (OR = 1.16 and 2.24, respectively), were significantly associated with MACE. None of the risk factors were significantly associated with MACE in the CAC &gt; 0 subgroup. Overall, the PCE, Agatston, and their combination obtained an area under the receiver operating characteristic curve (AUC) of 0.501, 0.662, and 0.661, respectively. Separately, the AUC of PCE, Agatston, and their combination for statin non-users were 0.679, 0.753, and 0.734, while that for statin-users were 0.585, 0.615, and 0.631, respectively. Only the performance of PCE alone was statistically significant (p = 0.025) when compared between statin-users (0.507) and non-users (0.783).ConclusionIn a symptomatic mixed Asian cohort, age, presence of CAC, and ln(Volume) were independently associated with MACE for the overall subgroup, age and PCE score for the CAC = 0 subgroup, and no risk factor for the CAC &gt; 0 subgroup. Whilst the PCE performance deteriorated in statin versus non-statin users, the Agatston score performed consistently in both groups.
Reservoir properties and hydrocarbon enrichment law of Chang 1 oil layer group in Yanchang Formation, Wanhua area, Ordos Basin
Authors: Ji Chaohui , Xue Chengwei , Sun Min , Li Xiang , Wang Li 
Published: January 2023

Evaluation of tight oil reservoir properties is of great significance to the exploration of oil and gas in tight reservoirs. The Chang 1 Member of the Yanchang Formation in the Wanhua Area, Ordos Basin is a new exploration stratum for tight sandstone oil. The lack of understanding of reservoir characteristics and crude oil enrichment rules has seriously restricted the efficient development of oil and gas resources in this stratum. In this study, the reservoir characteristics of the Chang 1 Member in the Wanhua area and the effects of superimposed sand bodies, structures and paleogeomorphology on accumulation of hydrocarbons were systematically studied. The Chang 1 sandstone is a typical ultra-low porosity-ultra-low permeability reservoir, and it has experienced destructive diagenesis of mechanical compaction, pressure solution and cementation, and constructive diagenesis of dissolution. Strong pressure solution caused the secondary enlargement of quartz and feldspar and the formation of patchy dense mosaic structures. The target layer has experienced argillaceous, siliceous and carbonate cementations. Moreover, the sandstone reservoir in the Chang 1 Member also experienced strong dissolution, and it is the main factor for the formation of secondary pores and the improvement of reservoir physical properties. The study also found that the main types of pores in the Chang 1 Member are intergranular dissolved pores and remaining intergranular pores. Superimposed sand bodies, nose-shaped uplifts, dominant facies and eroded paleo-highlands have significant effects on the hydrocarbon accumulation. Based on this study, it was found that the migration and accumulation mode of hydrocarbons in the Chang 1 reservoir belongs to the ladder-like climbing migration + structural ridge accumulation type. In addition, sand body thickness is an important controlling factor for the hydrocarbon accumulation. At present, the discovered crude oil in the Chang 1 Member is always distributed in the areas with thick sand bodies (&gt;20 m), and most of the sand bodies have a thickness in the range of 25–40 m, and the effective thickness is in the range of 2–6 m. In addition, the eroded highlands are the highest topographic units, they are favorable areas for the large-scale accumulation of oil and gas.
Study on stability of underlying room and pillar old goaf in close coal seam and mining of the upper coal seam
Authors: Liu Hongtao , Hao Cheng , Wang Zhiwen , Li Chong , Guo Linfeng , Liang Jialu , Wang Haozhu 
Published: January 2023

Possible issues during mining of the upper coal seam in old goaf of nearby coal seams, including step subsidence, gas overflow in goaf, and roadway around rock fragmentation. Using the Hanjiawa Coal Mine’s upper coal seam mining, which takes place 28 m above the working face of the lower coal seam, as the research’s focal point. The paper focuses on the self-stability of the coal pillar in the old goaf, the failure form of the upper coal seam mining floor, the roof caving rule of the old goaf in the lower coal seam mining of the upper coal seam, and the bearing capacity of the interlayer rock strata using the pillar goaf stability evaluation system, field geological borehole electrical logging and borehole peeping, finite element difference numerical calculation, and other methods. The conclusion that the old goaf’s coal pillar can be completely stable and that the interlayer rock strata can bear the stress of upper coal seam mining is reached. The results show that the failure depth of the coal pillar in the lower coal seam old goaf is 1–3 m, the maximum failure depth accounting for 15% of the width of the coal pillar, and the failure depth of the roof in the old goaf is 0–3 m; After the mining of the upper coal seam, the floor above the coal pillar of the lower coal seam is plastic failure, and the failure depth is 1–10 m, and the failure depth of the roof of the old goaf of the lower coal seam is 3–15 m, which is 4 times greater than that before the mining. The maximum failure depth of the interlayer rock strata is 22 m, accounting for 78.6% of the rock strata spacing. The interlayer rock strata can bear the mining disturbance of the upper coal seam. The plastic zone of the floor of the upper coal seam is not connected with the plastic zone of the roof of the lower coal seam.
Spatiotemporal dynamics of vegetation in response to climate variability in the Borana rangelands of southern Ethiopia
Authors: Worku Mitiku Adisu , Feyisa Gudina Legese , Beketie Kassahun Ture , Garbolino Emmanuel 
Published: January 2023

In this paper, we analyze the spatiotemporal dynamics of vegetation and its association with climate variables in the Borana rangelands of southern Ethiopia. Moderate resolution imaging spectroradiometer (MODIS) normalized difference vegetation index (NDVI) data, namely, MODIS/TERRA, MOD09Q1 16-day L3 Global 250 m Version 6 from National Aeronautics and Space Administration (NASA) United States Geological Survey (USGS), and climate data from 2000 to 2018 obtained from the National Meteorological Agency (NMA) of Ethiopia are used to determine the vegetation dynamics both at annual and seasonal timescales. The results indicate that the NDVI varies between .31 and .41, and the study area is dominated by sparse vegetation, especially shrubs and grasslands. The Borana rangelands were previously dominated by open grasslands, perennial herbaceous and woody vegetations, and some encroaching woody vegetations. The NDVI revealed poorer vegetation growth than the vegetation condition index (VCI) between 2000 and 2018, although variations were observed spatiotemporally. Rainfall was more highly variable both at annual and seasonal scales than the temperature during the studied years. The climate variables significantly determined the condition of vegetation, particularly during the growing seasons compared to other periods. A significant strong positive correlation was observed between the NDVI, VCI, and climate variables during the main (Belg) and short (Meher) rainy seasons in the Borana rangelands. The results of this study are beneficial for the development of proper intervention policies and provide information for sustainable rangeland management.
Androgen deprivation therapy and radiotherapy in intermediate-risk prostate cancer: A systematic review and meta-analysis
Authors: Chen Jiuzhou , Yuan Yan , Fang Miao , Zhu Youqi , Sun Xueqing , Lou Yufei , Xin Yong , Zhou Fengjuan 
Published: January 2023

ObjectivesAndrogen deprivation therapy combined with radiotherapy for intermediate-risk prostate cancer is still a matter of debate. We conducted a meta-analysis to evaluate the necessity of androgen deprivation therapy combined with radiotherapy for intermediate-risk prostate cancer patients.MethodsA comprehensive literature search of articles was performed in PubMed, Embase, Cochrane library, Web of Science, Chinese National Knowledge Infrastructure, Chinese Biological Medicine, Wanfang, and VIP Databases published between February 1988 and April 2022. Studies comparing the survival of patients diagnosed with intermediate-risk prostate cancer who were treated with androgen deprivation therapy combined with radiotherapy or radiotherapy alone were included. Data were extracted and analyzed with the RevMan software (version 5.3) and the Stata software (version 17).ResultsSix randomized controlled trials and nine retrospective studies, including 6853 patients (2948 in androgen deprivation therapy combined with radiotherapy group and 3905 in radiotherapy alone group) were enrolled. Androgen deprivation therapy combined with radiotherapy did not provide an overall survival (HR 1.12, 95% CI 1.01-1.12, p=0.04) or biochemical recurrence-free survival (HR 1.23, 95% CI 1.09-1.39, P=0.001) advantage to intermediate-risk prostate cancer patients.ConclusionAndrogen deprivation therapy combined with radiotherapy did not show some advantages in terms of overall survival and biochemical recurrence-free survival and radiotherapy alone may be the effective therapy for intermediate-risk prostate cancer patients.Systematic review registrationhttps://inplasy.com/inplasy-2022-8-0095/, identifier 202280095.
Optical and molecular diversity of dissolved organic matter in sediments of the Daning and Shennong tributaries of the Three Gorges Reservoir
Authors: Wang Kai , Fang Hongwei , He Guojian , Huang Lei , Cui Zhenghui , Gao Qifeng , Xu Song , Wang Dianchang , Wu Xinghua , He Ding 
Published: January 2023

Introduction: Damming significantly modifies the function of natural river networks and influences sediment dynamics with a reservoir’s operation. The dissolved organic matter (DOM) in reservoir sediments severely affects carbon flow from land to sea. However, the properties of DOM (e.g., quantity and quality) in reservoir sediments and their relationship with carbon cycling remain unclear as complex reservoir construction interrupts the environmental processes.Methods: This study characterizes the optical and molecular properties of sediment water-extractable organic matter (WEOM) in the Daning and Shennong tributaries of the world’s largest reservoir—the Three Gorges Reservoir (TGR)—by applying optical techniques and ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).Results and Discussion: We first assessed the link between light-absorbing components and the individual molecules in WEOM, which were significantly different than DOM in water and indicated that there might be an intrinsic variation between DOM in sediment and in water. Then, with the unique optical–molecular property linkage assessed, multiple sources (autochthonous and terrestrial) were identified, and a declining trend of terrestrial and recalcitrant WEOM was revealed from the tributaries upstream to downstream. Finally, through covariance analysis of the properties between WEOM and sediment particles, we demonstrated that the WEOM dynamic was most likely regulated by hydrologic sorting-induced particle size and mineral composition variations of sediment. Moreover, assessment between lability and WEOM molecular properties suggested that the WEOM dynamic likely contributes to carbon burial in the reservoir. This study emphasizes the influence of dam construction on organic matter accumulation and riverine carbon cycling.
Setting the Forestry Carbon Sink Insurance compensation standard for reducing losses from forest fires: An empirical study estimating CO2 emissions from forest fires in a sample of 15 provinces
Authors: Lv Huina , Shi Anqichen 
Published: January 2023

Introduction:Forest fires have contributed to increasingly serious global warming by great amount of CO2emissions and are seen as a loss of carbon sink value, which could be reduced by compensating economically via the Forestry Carbon Sink Insurance. However, estimating loss of carbon stock by estimating carbon emissions of forest fire losses is a crucial step of calculating the loss of carbon sink value.Methods:In this research, method proposed by Seiler and Crutzen (1980) was introduced to estimate the carbon emissions as CO2by in fifteen sample provinces in China by using official data in 2020, which would provide a scientific expectation in future.Results:Results show the range of carbon released in the sample provinces and we have estimated for the whole country during 2020——the overall amount of carbon released as CO2affected by forest fires reached 35017.42–98486.5t, which can be regarded as a loss of 35017.42–98486.5t of forest carbon sequestration capacity.Discussion:This study supplies one way of estimating loss of carbon sink value and provides evidence from China that the range of carbon stock loss because of forest fires. In practice, this study supports the forestry authorities to participate in the Forestry Carbon Sink Insurance and provides empirical data to establish compensation standards for insurance companies.
Neighbourhood characteristics, lifestyle factors, and child development: Secondary analysis of the All our families cohort study
Authors: MacKinnon A. L. , Sell H. , Silang K. , Xie E. B. , Jung J. W. , Tough S. , Tomfohr-Madsen L. 
Published: January 2023

BackgroundNeighbourhood characteristics have been found to influence child development, but little is known about lifestyle factors that may moderate this relationship, which can provide modifiable targets for policies and programing. This study investigated the association between neighbourhood characteristics (e.g., deprivation, disorder) during pregnancy and child development at age 5 in relation to various lifestyle factors (e.g., physical activity, parent-child reading, community resource use) during early childhood.MethodsA secondary analysis was conducted using multilevel modeling of data from the All Our Families cohort, recruited in Canada from 2008 to 2010. Participants self-reported on demographics during pregnancy, lifestyle factors at 3 years, and child development at 5 years using the Ages and Stages Questionnaire (ASQ-3). Neighbourhood deprivation was evaluated using the Vancouver Area Deprivation Index (VANDIX), while disorder was measured using police services' community crime reports.ResultsGeocoded information was available for 2,444 participants. After adjusting for covariates, multilevel modeling indicated a significant negative association between neighbourhood deprivation and overall child development (b = −.726, 95% CI: −1.344, −.120). Parent-child reading was found to be a significant moderator of the effect of neighbourhood disorder (b = .005, 95% CI: .001, .009). There were no statistically significant moderation effects for physical activity or community resource use.ConclusionNeighbourhood deprivation during pregnancy is associated with early child development. Parent-child reading may function as a protective factor in the presence of higher neighbourhood disorder. Overall, neighbourhood-level effects should be considered in policies and community programs that promote family and child well-being.
Holistic community-based group parenting programs for mothers with maternal mental health issues help address a growing public health need for a diversity of vulnerable mothers, children and families: Findings from an action research study
Authors: Aylward Paul , Sved Williams Anne 
Published: January 2023

BackgroundMaternal mental illness is a major growing global concern which can affect parenting with serious negative implications for offspring. Group-based parenting programs for mothers which both enhance the parent-child relationship and address mental health symptoms in a supportive social setting may optimise better outcomes for mothers and children. The Acorn program in South Australia draws on attachment theory to integrate dance play, reflective diary keeping and therapeutic letters in a holistic program for a diversity of vulnerable mothers and children aged 1–36 months. The program seeks to nurture and enhance parental wellbeing and the quality of the parent-child relationship for mothers experiencing identified mental health illnesses that impinge upon their parenting. This study presents the evaluation of the program and its effectiveness.MethodsAction research approach for continuous monitoring and program improvement engaging Acorn program staff in evaluation data collection and interpretation of pre and post self-completion measures and standardized observations. Additional data was collected through a telephone interview of attending mothers 6–8 months after program completion to address sustainable impacts on parenting and wellbeing.ResultsThe program engaged 353 diverse vulnerable mothers with their children. Many had profound overlapping mental health issues including borderline personality disorder (BPD) and depression. The quality of the parent-child interaction, parental confidence, competence and enjoyment were enhanced; mothers' wellbeing, ability to cope and lasting social supports were augmented. This occurred for a number of “most vulnerable” subgroups including single mothers, mothers with BPD, mothers from non-English speaking households and those with lower levels of education or household income. Mothers reported sustained improvements in their wellbeing, parenting, social and family lives, and feeling closer to their child as a result of participating in the program.ConclusionsGiven the high prevalence of maternal mental health issues and substantial potential negative consequences for mothers and offspring, the Acorn parenting program offers an effective means of addressing this pressing public health issue potentially helping large numbers of vulnerable mothers and their children. This has additional gravitas in the shadow of COVID-19 due to expanded numbers of those experiencing greater parental stress, isolation and mental illness.
Systemic CD4 cytotoxic T cells improve protection against PRRSV-1 transplacental infection
Authors: Li Yanli , Díaz Ivan , Martín-Valls Gerard , Beyersdorf Niklas , Mateu Enric 
Published: January 2023

BackgroundPorcine reproductive and respiratory syndrome virus (PRRSV) is one of the major swine pathogens causing reproductive failure in sows. Although modified-live virus (MLV) vaccines are available, only partial protection against heterologous strains is produced, thus vaccinated sows can be infected and cause transplacental infection. The immune effector mechanisms involved are largely unknown.MethodsThe present study investigated the role of cytotoxic lymphocytes, including cytotoxic T cells (CTL), NKT, and NK cells, from blood in preventing PRRSV-1 transplacental infection in vaccinated primiparous sows (two doses vaccinated). Sows from a PRRSV-1 unstable farm were bled just before the last month of gestation (critical period for transplacental infection), then followed to determine whether sows delivered PRRSV-1-infected (n=8) or healthy (n=10) piglets. After that, functions of CTL, NKT, and NK cells in the two groups of sows were compared.ResultsNo difference was found through cell surface staining. But upon in vitro re-stimulation with the circulating field virus, sows that delivered healthy piglets displayed a higher frequency of virus-specific CD107a+ IFN-γ-producing T cells, which accumulated in the CD4+ compartment including CD4 single-positive (CD4 SP) and CD4/CD8α double-positive (CD4/CD8α DP) subsets. The same group of sows also harbored a higher proportion of CD107a+ TNF-α-producing T cells that predominantly accumulated in CD4/CD8α double-negative (CD4/CD8α DN) subset. Consistently, CD4 SP and CD4/CD8α DN T cells from sows delivering healthy piglets had a higher virus-specific proliferative response. Additionally, in sows that delivered PRRSV-1-infected piglets, a positive correlation of virus-specific IFN-γ response with average Ct values of umbilical cords of newborn piglets per litter was observed.ConclusionOur data strongly suggest that CTL responses correlate with protection against PRRSV-1 transplacental infection, being executed by CD4 T cells (IFN-γ related) and/or CD4/CD8α DN T cells (TNF-α related).
Development of a prognostic model to identify the metastatic nasopharyngeal carcinoma patients who may benefit from chemotherapy combination PD-1 inhibitor
Authors: Liu Guo-Ying , Lu Nian , Bei Wei-Xin , Li Wang-Zhong , Liang Hu , Xia Wei-Xiong , Xiang Yan-Qun , Yao He-Rui 
Published: January 2023

BackgroundWe aimed to establish a prognostic model to identify suitable candidates for chemotherapy combination PD-1 inhibitor in metastatic nasopharyngeal carcinoma (NPC) patients.Patients and methodsIn this retrospective study, we included 524 patients (192 patients treated with chemotherapy combination PD-1 inhibitor and 332 received chemotherapy alone as first-line regimen) with metastatic NPC between January 2015 and March 2021. We developed a prognostic model to predict progression-free survival (PFS). A model-based trees approach was applied to estimate stratified treatment effects using prognostic scores and two well-matched risk groups (low-risk and high-risk) were created using propensity score matching.ResultsA prognostic nomogram was established with good accuracy for predicting PFS (c-index values of 0.71; 95% confidence interval, 0.66-0.73). The survival curves were significantly different between low-risk and high-risk groups (median PFS: 9.8 vs. 22.8 months, P &lt; 0.001, respectively). After propensity matching analysis, chemotherapy combination PD-1 inhibitor was significantly associated with superior PFS as compared with chemotherapy alone (median PFS, 10.6 versus 9.3 months, P = 0.016) in the high-risk group. However, no significant difference between chemotherapy combination PD-1 inhibitor and chemotherapy was observed (P = 0.840) in the low-risk groups.ConclusionsOur novel prognostic model was able to stratify patients with metastatic NPC into low-risk or high-risk groups and identify candidates for PD-1 inhibitor therapy. These results are expected to be confirmed by a prospective clinical trial.