bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of thrombospondin-1 and thrombospondin-2 with hematological, biochemical and inflammatory markers in COVID-19 patients
Authors: Dogan Serdar , Okuyan Hamza Malik , Bal Tayibe , Çabalak Mehmet , Begen Mehmet A. 
Published: June 2023

Abstract

Objectives
Roles of thrombospondin-1 (TSP-1) and thrombospondin-2 (TSP-2) in tissue repair and inflammation are well-documented, but the association of their serum expressions with the pathogenesis of COVID-19 remains unclear. We investigate the roles of TSP-1 and TSP-2 in COVID-19.

Methods
106 SARS-CoV-2 infected patients and 23 healthy people were enrolled in our study. COVID-19 patients were divided into two groups as non-severe and severe. TSP-1 and TSP-2 concentrations were measured with an enzyme-linked Immunosorbent Assay, and blood markers were analyzed with routine laboratory techniques.

Results
COVID-19 patients had significantly higher TSP-1 and TSP-2 levels than healthy controls. TSP-1 and TSP-2 positively correlated with inflammatory markers, including ESR, CRP, PCT, ferritin, and biochemical parameters such as ALT, AST, BUN, CK, and LDH. In addition, TSP-1 and TSP-2 were negatively correlated with hematological markers such as LYM, EOS, and HGB. Receiver operating characteristic analyses revealed that COVID-19 may be predicted with TSP-1 levels over 189.94 ng/mL and TSP-2 levels higher than 0.70 ng/mL.

Conclusions
Our analysis suggests that TSP-1 and TSP-2 expressions at the systemic level may have clinical importance for COVID-19.
Synthesis, characterization, luminescence, and catalytic properties of a zinc(II) complex with a N,O-donor ligand generated in situ from topiroxostat
Authors: Qin Chen-Chen , Sun Zhong-Hua , Rong Xin , Chen Sheng-Chun , He Ming-Yang , Chen Qun 
Published: June 2023

Abstract
By utilizing the well-known selective xanthine oxidase inhibitor topiroxostat, a new zinc(II) complex Zn(L)2(H2O)2 (1) [HL = 4-(3-(pyridine-4-yl)-1H-1,2,4-triazol-5-yl)picolinic acid] has been hydrothermally synthesized, involving in-situ ligand formation upon hydrolysis of topiroxostat. The complex has been structurally characterized by elemental analysis, IR spectroscopy, thermogravimetric analysis, powder X-ray diffraction, and single-crystal X-ray diffraction. X-ray structural analysis revealed that complex 1 is a N,O-chelating mononuclear Zn(II) complex. Complex 1 shows good thermal stability and exhibits photoluminescence in the solid state at room temperature. Moreover, complex 1 has been shown to be effective in the solvent-free ring-opening polymerization of ε-caprolactone without any co-catalyst or initiator.
A promise kept? The first years of experience of the Appeal Panel of the SRB
Authors: Lamandini Marco , Muñoz David Ramos 
Published: June 2023

Abstract
Within the institutional architecture for financial supervision within the EU, courts coexist with quasi-courts, i. e., review bodies like the ESAs Joint Board of Appeal, the SSM’s Administrative Board of Review (ABoR) and the SRB’s Appeal Panel. This has parallels e. g. US Administrative Law Judges (ALJs). Some argue that this flight away from courts is justified because administrative law and procedure are more flexible. Yet administrative mechanisms are deceptively simple. This paper offers a cautionary tale about the complexities of all quasi-judicial arrangements and their competing and complementary role with courts and presents an analysis of the European framework from both a functional and a comparative perspective.
Final Decision of the Single Resolution Board (SRB) Appeal Panel, BNP Paribas S.A., BNP Paribas Personal Finance and BGL BNP Paribas v the Single Resolution Board (Case 1/2022, 14 April 2023)
Authors: Appeal Panel  
Published: June 2023

Zusammenfassung
Nach Veröffentlichung der damals jüngsten Entscheidung des Joint Board of Appeal der ESAs vom 21. 7. 2022 in ZBB 2022, 240 findet sich nachfolgend die aktuellste Entscheidung einer weiteren Institution, die im Zuge der Bankenunion eingerichtet wurde, dem Beschwerdeausschuss des Einheitlichen Abwicklungsausschusses (SRB Appeal Panel), Art. 85 Abs. 1 VO (EU) Nr. 806/2014. Gem. Art. 85 Abs. 3 der Verordnung kann jede natürlich oder juristische Person einschließlich der Abwicklungsbehörden Beschwerde gegen einen der aufgeführten Beschlüsse des Abwicklungsausschusses einlegen, sofern dieser gegen sie gerichtet oder sie unmittelbar von diesem betroffen ist.
Die in der nachfolgenden Entscheidung verhandelten MREL waren auch bereits Thema der Entscheidung 3/22 des Beschwerdeausschusses vom 13. 2. 2023. Ausführungen zu dieser finden sich bei Lamandini/Ramos Munoz, ZBB 2023, 158 – in diesem Heft.
Safety and Efficacy of TACE + Lenvatinib in Treating Advanced Hepatocellular Carcinoma: A Systematic Review and Meta- analysis
Authors: Pan Di , Liu Haonan , Ma Xiao , Qu Pengfei , Cao Menghan , Qin Xiaobing , Tang Juanjuan , Pan Ronghai , Huang Qingchen , Han Zhengxiang 
Published: June 2023

Background and Aims: To compare the efficacy and safety of transarterial chemoembolization (TACE) + lenvatinib (TACE+L) versus lenvatinib (L) monotherapy in the treatment of advanced hepatocellular carcinoma by a meta-analysis.
Methods: PubMed, Embase, the Cochrane Library, CNKI, VIP e-Journals Database, and Wanfang Data were systematically searched to collate literature comparing TACE+L with L alone for the treatment of advanced liver cancer. The literature search, quality assessment, and data extraction were performed independently by two reviewers. The Stata 16 software package was used to process and analyze the data. We assessed heterogeneity using both I2 and the p-value, performed a publication bias assessment, and conducted a sensitivity analysis.
Results: Five studies were finally included, including one randomized controlled study and four retrospective studies; these involved a total of 1,167 patients, including 523 patients in the TACE+L combination group and 644 patients in the L monotherapy group. In this meta-analysis, the TACE+L group showed a significantly better objective response rate (ORR) (OR=2.54, 95%CI: 1.34 - 4.80) and disease control rate (DCR) compared to the L monotherapy group (OR=2.68, 95%CI: 1.75 - 4.08). The combined group had significantly improved progression-free survival (PFS) (HR=0.47, 95%CI: 0.40 - 0.56) and overall survival (OS) (HR=0.48, 95%CI: 0.39-0.59). In addition, there was no significant difference found in the overall adverse events of any grade between the two groups (OR=1.13, 95%CI: 0.99 - 1.29).
Conclusions: Compared to L alone, TACE+L treatment resulted in better tumor response, better long-term survival, and was accompanied by controllable adverse events.
Endoscopic Papillary Balloon Dilation Can Be Safely Performed in Patients on Dual Antiplatelet Therapy: A Pilot Study
Authors: Masuda Sakue , Jinushi Ryuhei , Koizumi Kazuya , Makazu Makomo , Nishino Takashi , Shionoya Kento , Kimura Karen , Sumida Chihiro , Kubota Jun , Ichita Chikamasa , Sasaki Akiko , Kobayashi Masahiro , Kako Makoto , Uojima Haruki , Sugitani Ayumu 
Published: June 2023

Background and Aims: Endoscopic papillary balloon dilation (EPBD), a low-risk procedure for bleeding, hasbeen suggested as an alternative to endoscopic sphincterotomy for papillary dilatation in patients undergoingendoscopic stone removal who are at a higher risk of bleeding. Several guidelines recommend that combinationof two antiplatelet agents should be reduced to single antiplatelet therapy when endoscopic sphincterotomyis performed. However, there is no evidence that EPBD affects the risk of bleeding in patients receiving acombination of two antiplatelet agents; thus, we aimed to explore this problem.
Methods: We included 31 patients who underwent EPBD for common bile duct stones at our hospital fromMay 2014 to August 2022 and received either a combination of two antiplatelet agents or single antiplatelettherapy prior to the procedure. The group receiving a combination of two antiplatelet agents included patientswho underwent EPBT without antiplatelet therapy withdrawal or with a shorter withdrawal period than thoserecommended by the guidelines.
Results: In the group that received a combination of two antiplatelet agents, one of the two antiplateletagents used was thienopyridine. No bleeding was observed after EPBD in this study. We did not findany significant between-group differences in hemoglobin levels and rate of post-endoscopic retrogradecholangiopancreatography pancreatitis.
Conclusions: In patients treated with a combination of two antiplatelet agents, EPBD could be safely performedwithout bleeding. Therefore, future prospective studies are warranted.
Feasibility and Safety of Through-the-scope versus Over-the-wire Stents for the Palliation of Malignant Dysphagia. A Cohort Real- Life Study
Authors: Tejedor-Tejada Javier , Hermida Benito , Pipa-Muñiz Maria , Garcia-Suarez Covadonga , Salman Zhuraida , Gomez Cesar , Alvarez-Alvarez Aranzazu , Perez-Pariente Jose 
Published: June 2023

Background and Aims: In the presence of malignant dysphagia in non-surgical candidates, a self-expanding metal stent (SEMS) represents a safe and effective approach. Recently, a through-the-scope (TTS) SEMS was launched. The aim of our study was to assess the feasibility and safety of the TTS versus over-the-wire (OTW) SEMS in patients with malignant dysphagia.
Methods: This single-center retrospective cohort study included patients with malignant dysphagia undergoing esophageal TTS and OTW-SEMS from 2012 to May-2022. The primary outcomes were the technical and the clinical success of the SEMS placement. Secondary outcomes included adverse events, patency, and survival. Patients were prospectively followed until death or loss of follow-up.
Results: A total of 98 patients were enrolled, including 34 patients in the TTS group and 64 patients in the OTW group. TTS and OTW SEMS placement were feasible in 33 (97.1%) and 64 (100%) procedures , respectively (p=0.118). Overall, 32 patients (94.1%) in the TTS group and 62 patients (96.9%) in the OTW group showed an improvement in Ogilvie score (p=0.432). Recurrent dysphagia occurred in 30 patients, 12 in TTS group and 18 in OTW group, due to migration (4 vs. 5), stent deformation (1 vs. 1), tissue ingrowth (5 vs. 5) and overgrowth (2 vs. 7). No patient died from a stent-related cause. Median survival was 123 days (IQR: 59-209) in TTS group and 113 days (IQR: 73-271) in OTW group (p=0.349).
Conclusions: Placement of esophageal TTS and OTW stents resulted in similar technical and clinical outcomes, stent patency and survival in patients with malignant dysphagia.
Clinical Characterization of HCC/CCA Mixed Cancers in a Population-based Cohort
Authors: Teufel Andreas , Rodriguez Isaac , Winzler Claudia , Kokh Daria , Ebert Matthias P. , Surovtsova Irina , Morakis Philipp 
Published: June 2023

Background and Aims: Primary liver cancer (PLC) ranks among of the most common cancers worldwide. Within this group, a minority of cases displays characteristics of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), known as combined hepatocellular cholangiocarcinoma (cHCC- CCA). Currently, there is no specific standardized therapy for these mixed tumors. Therefore, the aim of our study was to analyze the clinical course, treatment and outcome of cHCC-CCA patients in a European population-based registry.
Methods: We investigated 9,144 patients with PLC (6,622 HCC, 2,356 iCCA, and 166 cHCC-CCA) diagnosed between 2009 and 2020. All data were obtained from Clinical Cancer Registry of Baden-Württemberg (BW), Germany.
Results: In all three groups patients were predominantly male (82%, 57%, and 68% for HCC, iCCA and cHCC-CCA groups, respectively). 48% of cHCC-CCA patients were diagnosed as stage IV cancers, which was more than for HCC (31%) but less compared to CCA (64%). Overall median survival of cHCC-CCA patients was worse compared to HCC (9-13 months vs. 15.5 months, p<0.001) and rather comparable to CCA (11.8 months).
Conclusions: Our data demonstrated that cHCC-CCA tumors appear to have a distinct clinical course with worse overall survival compared to HCC. Thus, identification of these cancers by histopathology is essential in order to further characterize this tumor entity and to provide accurate treatment to these patients.
Prevalence and distribution of high-risk Human Papillomavirus in Western Türkiye between 2019 and 2022
Authors: Ece Gülfem Terek , Pira Doğukan , Bodur Gökçe Lara 
Published: June 2023

AbstractHuman Papillomavirus (HPV) is a primarily sexually transmitted human pathogen linked with the formation of anogenital warts and several types of cancer including cervical cancer, oropharyngeal cancer, penile cancer, and anal cancer. HPV genotypes are divided into high-risk and low-risk in accordance with their potential for carcinogenesis. The most notable high-risk genotypes are HPV-16 and HPV-18. In this study we report on the PCR analysis results of the cervical smear results of 328 females, and 50 males who have presented to a tertiary care university hospital in the port city of İzmir, Türkiye between August 2019 and August 2022. HPV-DNA positivity percentage was determined as 25.3% (96/378). 5 of 378 patients were HPV-18 positive (age range 31–80) whereas 27 patients were HPV-16 positive (age range 29–66). 64 patients were positive for other high-risk HPV types (age range 27–56). The positivity for HPV-16, HPV-18 and other high-risk HPV types were determined as 7.14%, 1.3% and 16.9% respectively. Our results demonstrate a 25.3% (96/378) positivity among tested patients moreover, out of 96 positive cases at least 32 are vaccine preventable. This study indicates the need for higher coverage of HPV vaccination in Western Türkiye.
Quality changes of Hoa Loc mangoes (Mangifera indica L.) during storage: Effect of chitosan-based nano-silver film coating
Authors: Nguyen H.D.T. , Nguyen L.P.L. , Nguyen V.D. , Duong Q.D. , Nguyen B. Ly 
Published: June 2023

AbstractThe aim of this study was to evaluate the possibility of storage of mangoes (Mangifera indica L.) coated with chitosan-based nano-silver films. Chitosan-based nano-silver films were first made using chitosan with three degrees of deacetylation of 70, 80, and 90%. The films were then used for coating the mango fruits. All coated mangoes and the control samples were stored at 12 °C in a cooling room. The respiration rate, ethylene production rate, weight loss, firmness, total soluble solids, total acid, vitamin C, total sugar, and change of peel colour were evaluated once every 5 days during the storage period. As observed, the coating using the chitosan-based nano-silver films did not induce significant negative alterations on most of the physical characteristics and chemical constituents of the fruits. In addition, the coating using those materials helped reduce the respiration and the ethylene gas production and retard the ripening process of mango fruits. The chitosan-based films with higher deacetylation degrees (CN80 and CN90) better moderated the respiration of mangoes. The coating using chitosan-based nano-silver films prolonged the shelf-life of mangoes (up to 35 days) compared to the control (less than 10 days).
Yunus Emre’s Grammar of the Self
Authors: CONTE Francesco 
Published: June 2023

In this paper, I would like to take into account some of the main elements that in my
opinion forge Yunus Emre’s form of life and that are directly reflected in his Divan, one
of the most important works of Turkish poetry written during the XIII and XIV centuries.
Although we have little information about Yunus Emre’s life, we know for sure that he
was a dervish, a person who followed the path of Sufism. I will investigate to what extent
Yunus Emre’s Divan relates to his spiritual journey experiences. What can we understand
about his life by reading his poetry? Did he write to witness his innermost experiences?
Did he write to understand his journey toward the Ineffable Absolute (Hakk)? What is the
relationship between his way of walking along the spiritual path and his conception of
language?
Evliya Çelebi Seyahatnâme’sinde Tılsımlar
Authors: ÇAKMAK Cengiz 
Published: June 2023

Evliya Çelebi’nin Seyahatnâme’sinde en çok karşılaşılan mitolojik unsur tılsımlardır.
Tılsım olgusu, tarihsel süreci boyunca temeldeki koruyuculuk anlamının yanında başka
anlamlandırmalarla karşımıza çıkmaktadır. Evliya Çelebi’ye baktığımızda ise seyahat
olgusunun ve seyyahın anlatım gücü dolayısıyla tılsımın, sözlük anlamlarının ötesinde
ve o anlamları genişleten, dal budak salarak yeni anlamlandırmalara yol açan kullanımlarına
şahit olunmaktadır. Her türlü “yeni” ile karşılaşmanın harikuladeliğinden, bunun
verdiği hayretten ve coğrafyaların kültürel birikiminden gelen kaynaklar ile seyyah, tılsımın
tanımına yeni bakış açıları getirmektedir. Seyahatnâme’de tılsım olgusunun anlam
evreninin yedi başlık altında toplanabileceği tespit edilmiştir: koruyuculuk, arıtıcılık ve
hüküm vericilik, bereket, kural koyuculuk, şifa, gösterge veya bir durumu nitelemenin
işareti, acayiplik.
Dynamics of changes in tumor-associated macrophages in patients with primary skin melanoma depending on the method of surgical treatment
Authors: Yargunin S.  A. , Reshetov I.  V. , Shoikhet Ya.  N. , Pyatakov S.  N. 
Published: June 2023

Summary: Skin melanoma is one of the deadliest among human skin tumors, and surgery remains the first and main method in its combined treatment. Despite the seemingly radical nature of surgical interventions in patients with primary skin melanoma, the frequency of locoregional recurrence and metastasis remains high. The question of the impact of surgical treatment on the evolution of the melanoma microenvironment remains unclear.Aim: to investigate the dynamics of polarization in tumor-associated macrophages in patients with primary skin melanoma of stage 0-IIa and in subsequent metastatic lesions to assess the impact of postoperative ischemia on survival of patients.Results: it was found that in patients with primary skin melanoma of stage 0-IIa plastic replacement of a tissue defect, compared with conventional suturing, can lead to a decrease in the density in the intrastromal distribution of pro-inflammatory CD68 + macrophages in the surgical focus, as well as less frequent polarization of TAM cells in the M2 direction and migration to the intrastromal component of the tumor, their more frequent mixed content, which, as a result, affects the survival of this category of patients for the better.Conclusions: plastic closing a surgical defect in patients with primary skin melanoma of stage 0-IIa may affect the duration of postoperative ischemia and the polarization of TAM cells. Plastic replacement of a tissue defect after tumor removal improves five-year survival rates (PFS by 22,6 % (p = 0.003) and OS by 13,1% (p = 0.029).
Tanggungjawab Notaris Terhadap Sengketa Para Pihak Terkait Akta Perjanjian Utang Berdasarkan Keterangan Palsu
Authors: Nugrahani Linda , Sudarwanto Albertus Sentot , Mulyanto Mulyanto 
Published: June 2023

There are still many authentic deeds made by Notaries containing false satatements. This often causes problems and losses for one of the parties to the deed. This research is doctrinal legal research using primary and secondary legal materials hereinafter through statute and copcetional approach. The result showthat the factors behind the making of an authentic deed that containing false statements are the intentions of the appearers themselves or the Notary’s negligence towards the precautionary principle in making the deed. Regarding the false statements submitted by the appearers, the Notary cannot be held responsible for the loaaes incurred. It is entirely the responsibility of the appearer. Meanwhile, a Notary who knows informations that submitted by the appearer is fake for making the deed, then the Notary can be responsible both civilly, administratively, and criminally.
Keywords : responsibility; Notary; authentic deed.
Histopathological correlation in oral biopsies in clinically diagnosed pediatric oral lesions: A 12-year institutional archival study
Authors: Shafi Shugufta , Gupta Rakesh K , Anjum Rubeena , Kaur Mandeep 
Published: June 2023

: The present study was aimed to determine the histopathological correlation in lesions of oral cavity in children aged 14 years and below received for diagnosis in the Oral Pathology Department of the Indira Gandhi Government Dental College Jammu, J&K. : The archives of the Department of Oral Pathology and Microbiology were retrospectively analyzed. Biopsy records of all oral lesions from pediatric patients, aged 0–14 years, from Department Of Oral and Maxillofacial Pathology & Oral Microbiology, Indira Gandhi Government Dental College Jammu, J&K, from 2011 to 2022 were considered. Descriptive statistical analysis and using computer software Pearson’s Chi‑square test was performed.: 36 biopsies (4.9%) belonged to pediatric population out of the total 727 biopsies that were received during the period. Females (64%) showed greater prevalence compared to males (36%). Affected age group seen were between10–14 years. The most common category of lesions diagnosed were cysts and the odontogenic tumors were the least seen. Mandible showed more predilection compared to maxilla in jaws which was most common location involved, followed by the gingiva, palate, lower lip and labial mucosa. On comparing the histopathological diagnosis, dentigerous cysts (22%) were the most common followed by radicular cysts (17%), fibrous hyperplasia (14%), pyogenic granuloma (11%), central giant cell granuloma (8%), hyperplasia of minor salivary glands (5.6%) and percentage of aneurysmal bone cyst, peripheral giant cell granuloma, peripheral ossifying fibroma, central ossifying fibroma, juvenile ossifying fibroma, cementoblastoma, ameloblastoma and necrotic bone all was equal (2.8%). A statistically significant association of age and gender was seen with the category of the lesion.:The lesions were more common in the mandible with a female predilection and in age group &#62;10 years. The majority of oral and maxillofacial lesions detected in pediatric population were benign similar to the previous reports.
Spectrum of Colorectal Adenocarcinomas: A 4 year experience in a tertiary care centre from Western Maharashtra
Authors: Lakhe Rachana , Patil Amrutraj , Doshi Rajeev , Doshi Preeti , Kesarkhane Milind , Nimbargi Ravindra 
Published: June 2023

Colorectal cancer is the third most common cancer in both men and women. Environmental and genetic factors play a role in the development of colorectal carcinomaThe majority of colorectal cancers are sporadic, with hereditary cancer syndrome accounting for 10% of cases. Precursor lesions like adenoma that transform into adenocarcinoma cause the majority of colorectal cancers. : A total of 72 of colorectal malignancies were studied for histopathological features. The histologic features were studied for site, grade, tumor -infiltrating lymphocytes, Crohn -like lymphocytic reaction, mucinous histology, signet ring cell histology, and medullary growth pattern.: The mean age of the patients was 59.52 ± 11.80 years with M:F 1.76:1. Light microscopy showed TILs in 16 (22.2%) patients, followed by mucinous areas in 5 (6.9%), crohn like lymphocytic reaction in 4 (5.6%) and signet ring morphology in 2 (2.8%) patients.This study concludes that colorectal carcinomas are more common in 5th and 6th decade of life with slight male preponderance. The most common malignant lesion being moderately differentiated adenocarcinomas. This study highlights age and gender prevalence, as well as histopathological characteristics of colorectal carcinomas in this demographic region .