bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theta burst stimulation add on to dialectical behavioral therapy in borderline-personality-disorder: methods and design of a randomized, single-blind, placebo-controlled pilot trial
Authors: Kujovic Milenko , Benz Daniel , Riesbeck Mathias , Bahr Christian , Kriegs Christian , Reinermann Dirk , Jänner Michaela , Neufang Susanne , Margittai Zsofia , Kamp Daniel , Plewnia Christian , Meisenzahl Eva 
Published: September 2023

AbstractSpecialized psychotherapeutic treatments like dialectical behavioral therapy (DBT) are recommended as first treatment for borderline personality disorder (BPD). In recent years, studies have emerged that focus on repetitive transcranial magnetic stimulation (rTMS) in BPD. Both have independently demonstrated efficacy in the treatment of BPD. Intermitted theta burst stimulation (iTBS), a modified design of rTMS, is thought to increase the excitability of neurons and could be a supplement to psychotherapy in addition to being a standalone treatment. However, no studies to date have investigated the combination of DBT and rTMS/iTBS. This study protocol describes the methods and design of a randomized, single-blinded, sham-controlled clinical pilot study in which BPD patients will be randomly assigned to either iTBS or sham during four consecutive weeks (20 sessions in total) in addition to standardized DBT treatment. The stimulation will focus on the unilateral stimulation of the left dorsolateral prefrontal cortex (DLPFC), which plays an important role in the control of impulsivity and risk-taking. Primary outcome is the difference in borderline symptomatology, while secondary target criteria are depressive symptoms, general functional level, impulsivity and self-compassion. Statistical analysis of therapy response will be conducted by Mixed Model Repeated Measurement using a 2 × 2-factorial between-subjects design with the between-subject factor stimulation (TMS vs. Sham) and the within-subject factor time (T0 vs. T1). Furthermore, structural magnetic resonance imaging (MRI) will be conducted and analyzed. The study will provide evidence and insight on whether iTBS has an enhancing effect as add-on to DBT in BPD.Trial registration: drks.de (DRKS00020413) registered 13/01/2020.
Development of the prosencephalic structures, ganglionic eminence, basal ganglia and thalamus at 11 + 3 to 13 + 6 gestational weeks on 3D transvaginal ultrasound including normative data
Authors: Altmann R. , Rechberger T. , Altmann C. , Hirtler L. , Scharnreitner I. , Stelzl P. , Enengl S. 
Published: September 2023

Abstract
Objectives
To show the development of ganglionic eminence, basal ganglia and thalamus/hypothalamus in week 11 + 3 to 13 + 6 by transvaginal 3D ultrasound.

Methods
To visualize the prosencephalic structures surrounding the 3rd ventricle, 285 three-dimensional ultrasound volume blocks from 402 fetuses examined were selected in a prospective transvaginal 3D study to compare ultrasound images of ganglionic eminence, basal ganglia, thalamus/hypothalamus with embryological sections. In addition, measurements of the described structures were made in 104 fetuses to quantify the embryological development.

Results
The sonomorphologic characteristics of ganglionic eminence, basal ganglia and thalamus/hypothalamus are described in 71% of the fetuses examined. Measurements of the structures in 57% of the fetuses, show the following results: axGE ap = 0.17 + 0.112*CRL; axGE/I = 0.888 + 0.048*CRL; axGE/BG = 0.569 + 0.041*CRL; coGE/BG = 0.381 + 0.048*CRL; coTh lat = − 0.002 + 0.135*CRL; coTh/HyT = 3.68 + 0.059*CRL; co3.V lat = 0.54 + 0.008*CRL.

Conclusion
Transvaginal 3D neurosonography allows visualization and measurement of normal structures in the fetal prosencephalon at 11 + 3 to 13 + 6 weeks of gestation (GW) including details of ganglionic eminence (GE), basal ganglia (BG), and thalamus/hypothalamus (Th/HyT). Further scientific work is needed before using the results to decide on pathological changes in patients.
Thyroid dysfunction induced by anti-PD-1 therapy is associated with a better progression-free survival in patients with advanced carcinoma
Authors: Lu Yiran , Li Qingchen , Xu Lusi , Zheng Yanqing , Wang Yanchao , Liu Ying , Zhang Rui , Liao Lin , Dong Jianjun 
Published: September 2023

Abstract
Purpose
Thyroid dysfunction is the most common immune-related adverse event during anti-programmed cell death 1 (anti-PD-1) therapy. In this study, we monitored patients with advanced malignant tumors who received anti-PD-1 therapy to observe the characteristic of anti-PD-1 therapy-induced thyroid dysfunction and its correlation with prognosis.

Methods
Patients with advanced carcinoma treated with anti-PD-1 therapy were evaluated for thyroid function at baseline and after treatment initiation from August 2020 to March 2022. Seventy-three patients were finally included in the study.

Results
Among these patients, 19 (26.03%) developed thyroid dysfunction after receiving anti-PD-1 therapy. Primary hypothyroidism and thyrotoxicosis were the most common clinical manifestation. Anti-PD-1-induced thyroid dysfunction occurred 63 (26–131) days after administration; thyrotoxicosis appeared earlier than primary hypothyroidism. In Kaplan–Meier survival analysis, the progression-free survival (PFS) of the thyroid dysfunction group was better than that of the no thyroid dysfunction group (227 (95% confidence interval (CI) 50.85–403.15) days vs 164 (95% CI 77.76–250.24) days, p = 0.026). Male patients had better PFS than female patients (213 (95% CI 157.74–268.26) days vs 74 (95% CI 41.23–106.77) days, p = 0.031). In cox proportional hazards regression model, anti-PD-1-induced thyroid dysfunction remained an independent predictor of better PFS (hazard ratio (HR) = 0.339(0.136–0.848), p = 0.021).

Conclusion
Thyroid dysfunction is a common immune-related adverse events in advanced cancer patients treated with anti-PD-1 therapy and predicts a better prognosis.

Trial registration
This study was retrospectively registered with Trial ClinicalTrials.gov (NCT05593744) on October 25, 2022.
Line-tension limits for line singularities and application to the mixed-growth case
Authors: Conti Sergio , Garroni Adriana , Marziani Roberta 
Published: September 2023

AbstractWe study variational models for dislocations in three dimensions in the line-tension scaling. We present a unified approach which allows to treat energies with subquadratic growth at infinity and other regularizations of the singularity near the dislocation lines. We show that the asymptotics via Gamma convergence is independent of the specific choice of the energy and of the regularization procedure.
Diverse magma evolution recorded in trace element composition of zircon from Permo-Carboniferous rhyolites (NE German Basin, NW Polish Basin)
Authors: Słodczyk Elżbieta , Przybyło Arkadiusz , Pietranik Anna , Lukács Réka 
Published: September 2023

AbstractPermo-Carboniferous rhyolitic rocks are widespread in the NE German Basin and NW Polish Basin. Hafnium (Hf) and oxygen (O) isotopes analysed in zircon from these rocks suggest diverse sources and processes involved in the formation of rhyolitic magmas. In this study, detailed core-to-rim trace element compositions were analyzed in zircon from four localities that were previously analyzed for Hf and O isotopes. The trace element analyses, in particular Hf concentrations as well as Eu/Eu*, Ce/U, Yb/Gd, and Th/U ratios, are consistent with prolonged magma evolution in three localities from the NE German Basin (Fehmarn, Slazwedel and Penkun). The fourth locality within the NW Polish Basin (Wysoka Kamieńska) is consistent with a shorter period of magma evolution. Similar stages were distinguished in zircon from the three NE German Basin localities that include: early crystallization followed by rejuvenation with more primitive magma (stage A), subsequent fractional crystallization (stage B) and finally late crystallization in a saturated system or alternatively late rejuvenation with a more primitive magma (stage C). Interestingly magmatic rims on inherited zircon grains have compositions typical for late stage B and stage C, which is consistent with their late addition to evolving rhyolitic magma, most probably during assimilation and not during source melting. The zircon from the fourth, NW Polish Basin locality shows limited compositional variability consistent with the eruption of hot magma not long after the zircon started crystallizing. Thus trace element analyses in zircon provide a record of magmatic processes complementary to that of Hf and O isotope analysis, in that, a detailed analyses of core-to-rim compositional variations are particularly useful in distinguishing respective stages of magma evolution and can pinpoint the relative timing of inherited grains being incorporated into magma.
Competency-based assessment of pilots’ manual flight performance during instrument flight training
Authors: Sun Hong , Zhou Xin , Zhang Peiwen , Liu Xin , Lu Yunsong , Huang Hong , Song Wuyang 
Published: September 2023

AbstractA pilot's control behavior has a direct impact on aviation safety. To adapt to new flight training reforms, a competency-based assessment method is proposed in this paper. First, assessment scenarios, key competencies and observable behaviours were determined. Then, observable behavior assessment indexes were developed based on standard operating procedures and practical examination standards. Flight training data were analyzed based on curve similarity theory and a time series fast retrieval algorithm, and the assessment indexes were scored. The competency assessment method was established by quantifying “HOW MANY” and “HOW OFTEN” observable behaviors according to the assessment indexes score results. Finally, the fuzzy C-means clustering algorithm was used to classify the assessment values, and assessment results were obtained. A teardrop pattern procedure was used to test the reliability of the assessment method. The results indicate that the correlation coefficient between the model evaluation and the expert evaluation is 0.947 with a significance level of 0.01, reliably and objectively quantifying manual flight performance and improving the scientific nature of manual flight performance assessment methods. Flight training institutions can use this method to establish diverse assessment scenarios and formulate corresponding assessment indexes based on the characteristics of each pilot to reasonably evaluate the manual flight performance of pilot. Targeted training methods can then be adopted for pilot with different performance levels to improve their competency.
Reliability of the Colombian version of the Kidscreen-52 for a child and adolescent student population
Authors: Rodríguez Martha J. , Camargo Diana M. , Orozco Luis C. 
Published: September 2023

Abstract
Aim
To assess the reliability of the Colombian version of the Kidscreen-52 in school children and adolescents ages 8 to 18 in the city of Bucaramanga, Colombia.

Subject and methods
An evaluation of diagnostic technology was performed with 121 children and adolescents who completed the Colombian version of Kidscreen-52. The population was selected by cluster sampling in five public schools. Age, sex, socioeconomic condition, school grade, and the 10 dimensions of Kidscreen-52 were analyzed. The internal consistency of the responses was estimated via Cronbach’s alpha coefficient as a measure of the reliability of the Kidscreen scores; the test–retest reproducibility was evaluated calculating the intraclass correlation coefficient and the Bland–Altman limits of agreement method after the students completed the questionnaire twice.

Results
The mean age was 11.9 ± 2.5 years, and 67 (55.4%) were girls. Cronbach’s alpha ranged from 0.61 to 0.89 and intraclass correlation coefficient from 0.70 to 0.90. The mean difference was close to zero (–4.5) with narrow limits of agreement (–27.0 to 18.1). The Colombian version of the Kidscreen-52 showed excellent internal consistency (Cronbach’s alpha = 0.95).

Conclusion
The values for test–retest reproducibility were similar by sex, but the intraclass correlation coefficient was lower in the age 8 to 11 group compared to the age 12 to 18 group.
Bayer digestion maintenance optimisation with lazy constraints and Benders decomposition
Authors: Spiers Sandy , Bui Hoa T. , Loxton Ryan , Mansour Moussa Reda , Hollins Kylie , Francis Richard , Martindale Christopher , Pimpale Yogesh 
Published: September 2023

AbstractThis paper describes a maintenance scheduling model for digester banks. Digester banks are network-connected assets that lie on the critical path of the Bayer process, a chemical refinement process that converts bauxite ore into alumina. The banks require different maintenance activities at different due times. Furthermore, the maintenance schedule is subject to production-related constraints and resource limitations. Given the complexity of scheduling maintenance for large fleets of digester banks, a continuous-time, mixed-integer linear program is formulated to find the cost-minimising maintenance schedule that satisfies all required constraints. A solution approach that employs lazy constraints and Benders decomposition is proposed to solve the model. Unlike generic implementations of Benders decomposition, we show that the subproblems can be solved explicitly using a specialist algorithm. We solve the scheduling model for realistic scenarios involving two Bayer refineries based in Western Australia.
Cuprotosis clusters predict prognosis and immunotherapy response in low-grade glioma
Authors: Zhu Wenjun , Chen Ziqi , Fu Min , Li Qianxia , Chen Xin , Li Xiaoyu , Luo Na , Tang Wenhua , Yang Feng , Zhang Yiling , Zhang Yuanyuan , Peng Xiaohong , Hu Guangyuan 
Published: September 2023

AbstractCuprotosis, an emerging mode of cell death, has recently caught the attention of researchers worldwide. However, its impact on low-grade glioma (LGG) patients has not been fully explored. To gain a deeper insight into the relationship between cuprotosis and LGG patients’ prognosis, we conducted this study in which LGG patients were divided into two clusters based on the expression of 18 cuprotosis-related genes. We found that LGG patients in cluster A had better prognosis than those in cluster B. The two clusters also differed in terms of immune cell infiltration and biological functions. Moreover, we identified differentially expressed genes (DEGs) between the two clusters and developed a cuprotosis-related prognostic signature through the least absolute shrinkage and selection operator (LASSO) analysis in the TCGA training cohort. This signature divided LGG patients into high- and low-risk groups, with the high-risk group having significantly shorter overall survival (OS) time than the low-risk group. Its predictive reliability for prognosis in LGG patients was confirmed by the TCGA internal validation cohort, CGGA325 cohort and CGGA693 cohort. Additionally, a nomogram was used to predict the 1-, 3-, and 5-year OS rates of each patient. The analysis of immune checkpoints and tumor mutation burden (TMB) has revealed that individuals belonging to high-risk groups have a greater chance of benefiting from immunotherapy. Functional experiments confirmed that interfering with the signature gene TNFRSF11B inhibited LGG cell proliferation and migration. Overall, this study shed light on the importance of cuprotosis in LGG patient prognosis. The cuprotosis-related prognostic signature is a reliable predictor for patient outcomes and immunotherapeutic response and can help to develop new therapies for LGG.
Endogenous preferences: a challenge to constitutional political economy’s normative foundation?
Authors: Dold Malte 
Published: September 2023

AbstractThis paper starts with the observation from behavioral economics that preferences are endogenous, i.e., they are unstable, context-dependent, and open to processes of adaptation. It then asks whether welfare analysis and normative economics are still possible in a world populated by people with endogenous preferences. In particular, it looks at recent proposals by Viktor Vanberg and Carl Christian von Weizsäcker. In highlighting an institutional perspective, both can be seen as proponents of modern ordoliberalism and both claim that their approaches can deal with the issue of endogenous preferences in a more coherent way than approaches that remain within the mind frame of traditional welfare economics. The paper argues that in mainly highlighting the importance of information provision for individual autonomy, Vanberg’s approach of constitutional political economy (CPE) underestimates the complexity of preference endogeneity. While von Weizsäcker’s approach is a refinement of the CPE framework, the paper argues that it focuses too much on external structural conditions (viz., competition among interpersonal influences) and neglects a discussion of the necessary internal agentic capabilities for individual autonomy. The paper argues that a more intricate discussion of decision autonomy leads to a twin concern for outcome and process freedom in normative economics. Outcome freedom allows individuals to satisfy their evolving preferences and process freedom enables them to critically reflect upon their preferences and surroundings.
For Whom and What Does Cognitive Reappraisal Help? A Prospective Study
Authors: Dawel Amy , Mewton Paige , Gulliver Amelia , Farrer Louise M. , Calear Alison L. , Newman Eryn , Cherbuin Nicolas 
Published: September 2023

Abstract
Purpose
Recent literature highlights that no emotion regulation strategy is universally helpful or harmful. The present study aimed to build understanding of for whom and what cognitive reappraisal is helpful, by testing the influential hypothesis that reappraisal is most helpful when there is good individual or situational capacity to apply this strategy effectively.

Methods
The present study tested how eight variables theorised to be associated with the effectiveness of reappraisal moderated the link between reappraisal use and changes in depression, anxiety, loneliness, functional impairment, and wellbeing in a nationally representative sample, over three (n = 752) and twelve month (n = 512) periods.

Results
Contrary to our hypothesis, we found reappraisal was most beneficial for individuals or in situations characterised by additional vulnerabilities (e.g., average or high levels of stress, neuroticism, difficulty identifying feelings, or poor self-efficacy). Results also support prior evidence that reappraisal can be more helpful for improving wellbeing than reducing mental health symptoms.

Conclusions
Altogether, our findings provide new insight into the complex nature of relationships between reappraisal and psychological outcomes. A key clinical implication is that reappraisal may be particularly helpful for people with stable vulnerabilities (e.g., neuroticism).
Site Characterisation, Deep Basement Support, Construction, and Deformation Control
Authors: Haundi Tiyamike , Nangulama Horris K. , Mbewe Vincent R. 
Published: September 2023

AbstractDeep basement construction is characterised by a deformation challenge for the excavation pit and adjacent structures. Basement construction is an unavoidable problem in urban areas. A case is found in a Triumph Unit building block project, where a 14 m basement will be constructed near the existing structures. Conducting a site survey engineering analysis before the deep basement excavation is essential to guarantee safety during basement construction. Site survey engineering analysis is vital in recommending a suitable support structure for the basement pit during excavation. Therefore, this paper takes the Triumph Unit high-rise building basement excavation project as a practical application of site survey engineering analysis on the actual construction site. Geotechnical and groundwater characterisation were achieved through field and laboratory tests. The study revealed that the site was suitable for construction of bored piles as enclosure structure. It also recommended application of steel bracing material enhanced with a hydraulic servo system as basement excavation internal support structure. The recommended support structure is applied to the actual excavation. The excavation-induced deformation with respect to the recommended support structure application is strictly monitored and controlled. The measured project site results show the effectiveness of site survey engineering analysis in recommending a suitable deep basement excavation support system that controls the excavation-induced deformation desirably.
Fluorescence Naphthalene Cationic Schiff Base Reusable Paper as a Sensitive and Selective for Heavy Metals Cations Sensor: RSM, Optimization, and DFT Modelling
Authors: Tawfik Salah M. , Farag Ahmed A. , Abd-Elaal Ali A. 
Published: September 2023

AbstractHeavy metals are particularly damaging contaminants in the environment, and even trace concentrations represent a risk to human health due to their toxicity. To detect the heavy metals of Mn2+ and Co2+ ions, a novel selective reusable paper-based Fluorescence naked-eye sensor based on naphthalene cationic Schiff base (NCSB) was synthesized and confirmed using FT-IR, 1 H-NMR, and MS tools. Based on a blue to colorless color change in the aqueous solution, the NCSB sensor is utilized to Mn2+ and Co2+ cations selectively among other metal ions (Fe2+, Cu2+, Mg2+, Ni2+, Zn2+, Cd2+, Hg2+, Pb2+, Sn2+ and Cr3+). In the aqueous medium, the NCSB sensor displayed high sensitivity, with limits of detection (LOD) values of 0.014 µM (14.08 nM) and 0.041 µM (41.47 nM) for Mn2+ and Co2+ cations, respectively. The paper-based sensor naked-eye detected Mn2+ and Co2+ cations in water at concentrations as low as 0.65 µM (65 nM) and 0.086 µM (86 nM), respectively. It was discovered that 5 min of incubation time and a pH range of 7 to 11 were optimal for the complexation reaction between the Mn2+ and Co2+ ions and the NCSB sensor. Through a static quenching process, the interaction of the different metal ions with the Schiff base group in the NCSB molecule results in the development of a ground-state non-fluorescent complex. NCSB sensor was also successfully applied in analysis of Mn2+ and Co2+ in environmental water with good recoveries of 94.8–105.9%. The theoretical calculations based on density functional theory (DFT) studies are in support of experimental interpretations. The links between the input factors and the anticipated response were evaluated using the quadratic model of the response surface methodology (RSM) modeling.
Premeditated, Organized and Impactful: Dating Violence as a Method of Committing Hate Crimes Against LGBTQ People in Russia
Authors: Katsuba Sergei 
Published: September 2023

Abstract
Purpose
The purpose of the research is to identify and analyze the cases of dating violence among the hate crimes against LGBTQ people in Russia. Dating violence (attacks on LGBTQ people with the use of dating services) became a common method of committing hate crimes in Russia in the late 2010s and was enabled by the discriminatory policies of the state.

Method
This research is part of a bigger project on anti-LGBTQ violence. The project generated a database of more than 1000 cases of such violence between 2010 and 2020 using court rulings as a primary source of data The current research is a continuation of this effort, it is looking into a specific category of hate crime – premeditated attacks in order to analyze the cases of dating violence.

Results
The research established that most of the cases in the category of premeditated attacks are cases of dating violence (239 out of 347). Most of those crimes (209) are cases of collective violence (committed by different anti-LGBTQ hate groups). There is evidence of the community impact in the incidents and in the agendas of the hate groups.

Conclusions
The research adds to the theoretical model of the progression of prejudice and argues that dating violence represents a more developed form of violence against LGBTQ people. This is due to the three distinguishing features (premeditation, collective form, and community impact) that are present in the cases.