bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infection with Influenzavirus A in a murine model induces epithelial bronchial lesions and distinct waves of innate immune-cell recruitment
Authors: Rivière Frédéric , Burger Julien , Lefèvre François , Garnier Annabelle , Vigne Clarisse , Tournier Jean-Nicolas , Billon-Denis Emmanuelle 
Published: August 2023

IntroductionInflammatory lesions after Influenza A viruses (IAV) are potential therapeutic target for which better understanding of post-infection immune mechanisms is required. Most studies to evaluate innate immune reactions induced by IAV are based on quantitative/functional methods and anatomical exploration is most often non-existent. We aimed to study pulmonary damage and macrophage recruitment using two-photon excitation microscopy (TPEM) after IAV infection.MethodsWe infected C57BL/6 CD11c+YFP mice with A/Puerto Ricco/8/34 H1N1. We performed immune cell analysis, including flow cytometry, cytokine concentration assays, and TPEM observations after staining with anti-F4/80 antibody coupled to BV421. We adapted live lung slice (LLS) method for ex-vivo intravital microscopy to analyze cell motility.ResultsTPEM provided complementary data to flow cytometry and cytokine assays by allowing observation of bronchial epithelium lesions and spreading of local infection. Addition of F4/80-BV421 staining allowed us to precisely determine timing of recruitment and pulmonary migration of macrophages. Ex-vivo LLS preserved cellular viability, allowing us to observe acceleration of macrophage motility.ConclusionAfter IAV infection, we were able to explore structural consequences and successive waves of innate immune cell recruitment. By combining microscopy, flow cytometry and chemokine measurements, we describe novel and precise scenario of innate immune response against IAV.
Case Report: Replacement of PD-1 inhibitors with PD-L1 inhibitors in the treatment of squamous non-small-cell lung carcinoma
Authors: Wu Tong , Li Yujun , Cui Xiaonan , Zhang Chunxia 
Published: August 2023

BackgroundImmune checkpoint inhibitor (ICI)-associated cardiotoxicity is a relatively uncommon immune-related adverse effects (irAEs) with a high mortality rate. There are few recommendations for the replacement of different immune checkpoint inhibitors in domestic and international reports.Case presentationWe report a case of a patient with squamous non-small cell lung carcinoma (squamous NSCLC) who developed cardiotoxicity after being treated with a programmed death-1 (PD-1) inhibitor and then changed to a PD-L1 inhibitor to continue the treatment. A significant benefit was observed after four cycles of immunotherapy, and no further cardiotoxicity occurred after the treatment was started.ConclusionThis case demonstrates that myocardial damage induced by tislelizumab (PD-1 inhibitor) can be improved after switching to sugemalimab (PD-L1 inhibitor) and that antitumor immunotherapy is effective. This result may have important implications for optimizing immunotherapy management regimens in cancer patients.
AUV planning and calibration method considering concealment in uncertain environments
Authors: Wang Can , Cheng Chensheng , Yang Dianyu , Pan Guang , Zhang Feihu 
Published: August 2023

IntroductionAutonomous underwater vehicles (AUVs) are required to thoroughly scan designated areas during underwater missions. They typically follow a zig-zag trajectory to achieve full coverage. However, effective coverage can be challenging in complex environments due to the accumulation and drift of navigation errors. Possible solutions include surfacing for satellite positioning or underwater acoustic positioning using transponders on other vehicles. Nevertheless, surfacing or active acoustics can compromise stealth during reconnaissance missions in hostile areas by revealing the vehicle’s location.MethodsWe propose calibration and planning strategies based on error models and acoustic positioning to address this challenge. Acoustic markers are deployed via surface ships to minimize navigation errors while maintaining stealth. And a new path planning method using a traceless Kalman filter and acoustic localization is proposed to achieve full-area coverage of AUVs. By analyzing the statistics of accumulated sensor errors, we optimize the positions of acoustic markers to communicate with AUVs and achieve better coverage. AUV trajectory concealment is achieved during detection by randomizing the USV navigation trajectory and irregularizing the locations of acoustic marker.ResultsThe proposed method enables the cumulative determination of the absolute position of a target with low localization error in a side-scan sonar-based search task. Simulations based on large-scale maps demonstrate the effectiveness and robustness of the proposed algorithm.DiscussionSolving the problem of accumulating underwater localization errors based on inertial navigation by error modeling and acoustic calibration is a typical way. In this paper, we have implemented a method to solve the localization error in a search scenario where stealth is considered.
A prospective multicenter clinical research study validating the effectiveness and safety of a chest X-ray-based pulmonary tuberculosis screening software JF CXR-1 built on a convolutional neural network algorithm
Authors: Yang Yang , Xia Lu , Liu Ping , Yang Fuping , Wu Yuqing , Pan Hongqiu , Hou Dailun , Liu Ning , Lu Shuihua 
Published: August 2023

BackgroundChest radiography (chest X-ray or CXR) plays an important role in the early detection of active pulmonary tuberculosis (TB). In areas with a high TB burden that require urgent screening, there is often a shortage of radiologists available to interpret the X-ray results. Computer-aided detection (CAD) software employed with artificial intelligence (AI) systems may have the potential to solve this problem.ObjectiveWe validated the effectiveness and safety of pulmonary tuberculosis imaging screening software that is based on a convolutional neural network algorithm.MethodsWe conducted prospective multicenter clinical research to validate the performance of pulmonary tuberculosis imaging screening software (JF CXR-1). Volunteers under the age of 15 years, both with or without suspicion of pulmonary tuberculosis, were recruited for CXR photography. The software reported a probability score of TB for each participant. The results were compared with those reported by radiologists. We measured sensitivity, specificity, consistency rate, and the area under the receiver operating characteristic curves (AUC) for the diagnosis of tuberculosis. Besides, adverse events (AE) and severe adverse events (SAE) were also evaluated.ResultsThe clinical research was conducted in six general infectious disease hospitals across China. A total of 1,165 participants were enrolled, and 1,161 were enrolled in the full analysis set (FAS). Men accounted for 60.0% (697/1,161). Compared to the results from radiologists on the board, the software showed a sensitivity of 94.2% (95% CI: 92.0–95.8%) and a specificity of 91.2% (95% CI: 88.5–93.2%). The consistency rate was 92.7% (91.1–94.1%), with a Kappa value of 0.854 (P = 0.000). The AUC was 0.98. In the safety set (SS), which consisted of 1,161 participants, 0.3% (3/1,161) had AEs that were not related to the software, and no severe AEs were observed.ConclusionThe software for tuberculosis screening based on a convolutional neural network algorithm is effective and safe. It is a potential candidate for solving tuberculosis screening problems in areas lacking radiologists with a high TB burden.
Advances in the roles of glycyrrhizic acid in cancer therapy
Authors: Zhang Yuqian , Sheng Zixuan , Xiao Jing , Li Yang , Huang Jie , Jia Jinjing , Zeng Xiansi , Li Li 
Published: August 2023

Since the first 70 years of reporting cancer chemotherapy, malignant tumors have been the second most common cause of death in children and adults. Currently, the commonly used anti-cancer methods include surgery, chemotherapy, radiotherapy, and immunotherapy. Although these treatment methods could alleviate cancer, they lead to different forms of side effects and have no particularly significant effect on prolonging the patients’ life span. Glycyrrhizic acid (GL), a native Chinese herbal extract, has a wide range of pharmacological effects, such as anti-cancer, anti-inflammatory, antioxidant, and immune regulation. In this review, the anti-cancer effects and mechanisms of GL are summarized in various cancers. The inhibition of GL on chemotherapy-induced side effects, including hepatotoxicity, nephrotoxicity, genotoxicity, neurotoxicity and pulmonary toxicity, is highlighted. Therefore, GL may be a promising and ideal drug for cancer therapy.
Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation
Authors: Liufu Tongling , Yu Haiyan , Yu Jiaxi , Yu Meng , Tian Yue , Ou Yichun , Deng Jianwen , Xing Guogang , Wang Zhaoxia 
Published: August 2023

Introduction: Mitochondrial disease is a spectrum of debilitating disorders caused by mutations in the mitochondrial DNA (mtDNA) or nuclear DNA that compromises the respiratory chain. Mitochondrial 3243A&gt;G (m.3243 A&gt;G) is the most common mutation showing great heterogeneity in phenotype. Previous studies have indicated that NADH: ubiquinone oxidoreductase (complex I) deficiency accompanied by a decreased nicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) ratio may play a pivotal role in the pathogenesis of m.3243A&gt;G mutation.Methods: To evaluate the potential effects of strategies targeting the imbalanced NAD+/NADH ratio in m.3243A&gt;G mutation, we treated fibroblasts derived from patients with the m.3243 A&gt;G mutation using nicotinamide riboside (NR) or mitochondria-targeted H2O-forming NADH oxidase (mitoLbNOX).Results: M.3243 A&gt;G fibroblasts showed a significant reduction in complex I core subunit 6, complex I enzymatic activity, complex I-dependent oxygen consumption rate (OCR), and adenosine triphosphate (ATP) production compared to the controls. The NAD+/NADH ratio was also significantly reduced in m.3243 A&gt;G fibroblasts, and, using fluorescence lifetime imaging microscopy, we also found that the NADH level was elevated in m.3243 A&gt;G fibroblasts. After NR treatment, the NAD+/NADH ratio, complex I-dependent OCR, and ATP levels increased, whereas NADH levels remained unchanged. More excitingly, after treatment with mitoLbNOX, the NAD+/NADH ratio, complex I-independent OCR, and ATP levels increased more pronouncedly compared with the NR treatment group, accompanied by significantly reduced NADH levels.Discussion: The present study suggests that compared with repletion of NAD+ alone, the combination of this therapeutic modality with alleviation of NADH overload may amplify the treatment effect of restoring NAD+/NADH balance in m.3243A&gt;G fibroblasts.
Disparities in outcomes of COVID-19 hospitalizations in native American individuals
Authors: Bime Christian , Wang Ying , Carr Gordon , Swearingen Dennis , Kou Sherri , Thompson Pam , Kusupati Vinita , Parthasarathy Sairam 
Published: August 2023

ObjectivesThis study aimed to investigate COVID-19-related disparities in clinical presentation and patient outcomes in hospitalized Native American individuals.MethodsThe study was performed within 30 hospitals of the Banner Health system in the Southwest United States and included 8,083 adult patients who tested positive for SARS-CoV-2 infection and were hospitalized between 1 March 2020 and 4 September 2020. Bivariate and multivariate analyses were used to assess racial and ethnic differences in clinical presentation and patient outcomes.ResultsCOVID-19-related hospitalizations in Native American individuals were over-represented compared with non-Hispanic white individuals. Native American individuals had fewer symptoms at admission; greater prevalence of chronic lung disease in the older adult; two times greater risk for ICU admission despite being younger; and 20 times more rapid clinical deterioration warranting ICU admission. Compared with non-Hispanic white individuals, Native American individuals had a greater prevalence of sepsis, were more likely to require invasive mechanical ventilation, had a longer length of stay, and had higher in-hospital mortality.ConclusionNative American individuals manifested greater case-fatality rates following hospitalization than other races/ethnicities. Atypical symptom presentation of COVID-19 included a greater prevalence of chronic lung disease and a more rapid clinical deterioration, which may be responsible for the observed higher hospital mortality, thereby underscoring the role of pulmonologists in addressing such disparities.
SMART HYDROPONIC BERBASIS ANDROID DI SMKN 6 KENDAL
Authors: Aji Saputra Muhammad , Riyanto Eko , Solikhin  
Published: August 2023

The rapid development of technology makes people innovate to make new things and leave old ways to simplify and save time a job. One example is monitoring the value of pH, PPM, room temperature and humidity as well as water temperature of hydroponic plants that used to still use conventional tools, now switching to Android-based IoT technology (Smart Hydroponics), especially at SMKN 6 Kendal.
IoT is a way of connecting the Arduino sensor modules needed for hydroponic cultivation, where the results of sensor readings will be actually sent to the user's Android smartphone. The Arduino sensors are pH, TDS, DHT 11, ds1820 sensors.
With this smart hydroponics, it is hoped that it can help hydroponic cultivators in the SMKN 6 Kendal environment to monitor their gardens anywhere and anytime and control the hydroponic temperature to be maintained below 30 degrees. From the reading of the value of the smart hydroponic sensor, it works well with existing standards and through MAPE calculations with a value below 10%.
IMPLEMENTASI ALGORITMA APRIORI DALAM MENENTUKAN POLA PEMBELIAN (CAP N CHRIS CAFÉ & RESTO JEPARA) BERBASIS WEB
Authors: Surur Misbakhus , Saputro Heru , Azizah Noor 
Published: August 2023

Dengan adanya kemajuan teknologi yang pesat pada saat ini membuat banyaknya jumlah transaksi penjualan yang diterima setiap harinya. Jumlah kenaikan penjualan tentunya membawa kebaikan. Namun dengan adanya kegiatan penjualan membuat data penjualan menu makanan semakin lama semakin tambah banyak. Dan data tersebut hanya berfungsi sebagai arsip saja.Penelitian ini bertujuan untuk membuat aplikasi berbasis website dengan Algoritma Apriori dengan memanfaatkan data transaksi penjualan, dengan menetukan hubungan antar item dari data penjualan, dalam hal ini adalah makanan atau minuman yang dipesan sehingga dapat ditemukan pola pembelian konsumen. Hasil penelitian yang dilakukan dari data 16 transaksi didapatkan 4 aturan asosiasi dengan minimun support 3 dan minimun confidence 6.
SISTEM PENDUKUNG KEPUTUSAN LATIHAN GERAKAN FITNESS BAGI PEMULA MENGGUNAKAN METODE WEIGHTED PRODUCT
Authors: Rahmatullah Robby , Adimahendra Wahyu 
Published: August 2023

Agna Physque Gym adalah tempat Fitness yang beralamatkan di Kecamatan Gemolong. Agna Physque Gym menyediakan pelayanan dan fasilitas yang memadai serta upaya menumbuhkan minat masyarakat dalam berolahraga. Program latihan untuk pemula tentu memerlukan bimbingan dari personal trainer dalam menyusun program latihan yang sesuai dengan target yang diinginkan. Para Pemula dan Member Fitness memiliki kendala dalam menentukan program latihan. Hal ini merupakan suatu kesulitan dalam menentukan program latihan yang akan dilakukan.
Penelitian ini bertujuan untuk membangun sebuah Sistem Pendukung Keputusan untuk menentukan Program latihan Fitness dengan menggunakan metode Weighted Product. Metode Weighted Product menggunakan perkalian untuk menghubungkan rating atribut, dimana rating setiap atribut harus dipangkatkan terlebih dahulu dengan bobot atribut yang bersangkutan. Proses ini sama halnya dengan proses normalisasi. Sistem dibangun menggunakan bahasa pemrograman java dan database menggunakan MySQL.
Sistem ini dapat menghasilkan perankingan alternatif program latihan Fitness sesuai dengan berat badan user. Berdasarkan pengujian sistem yang dilakukan, sistem mampu memberikan hasil yang sesuai dengan perhitungan yang digunakan, sehingga dengan adanya sistem ini dapat membantu dalam menentukan rekomendasi latihan Fitness.
ANALISIS POLA PEMBELIAN PRODUK PADA TOKO MADU MUKTI DENGAN ALGORITMA APRIORI
Authors: Rohman Saifu , Azis Zen Al , Hidayat Muslim 
Published: August 2023

Algoritma apriori adalah algoritma dari teknik Association Rules Mining (ARM) dan termasuk dalam bagian metode data mining untuk menentukan pola frekuensi tinggi. Dengan menggunakan algoritma apriori akan menghasilkan output kombinasi barang dimana jika nilai minimum confidence semakin besar maka hasil kombinasi barang akan semakin valid jika nilai supportsemakin tinggi maka seleksi kombinasi tiap itemset akan semakin spesifik.
DESIGN OF REINFORCED CONCRETE ELEMENTS INCLINED SECTIONS SUBJECTED TO BIAXIAL ACTION OF SHEAR FORCES
Authors: Shipulin S. , Belyaeva Z. , Mironova L. 
Published: August 2023

In the current standards for the design of reinforced concrete structures no methods for calculating inclined sections with a biaxial action of shear forces are presented. At the same time, a significant part of reinforced concrete structures is subjected to the action of shear forces in two planes. The relevance of the article is determined by the lack of standard methods for calculating of reinforced concrete elements inclined sections for the biaxial action of shear, which forces designers to use simplifications in calculations. The article reviews the Russian and foreign literature on the theory of design of reinforced concrete elements for the action of transverse forces and analyzes the design methods proposed in the current Russian and foreign design standards, as well as in the standards of past years. In the analysis of methods for calculating reinforced concrete elements for the action of transverse forces, consideration is given in various methods for calculating the factors that affect the strength of inclined sections on the action of transverse forces in normal and biaxial bending in two planes, such as the shear span, the angle of inclination of the force plane, the amount of longitudinal tensile reinforcement, the influence of longitudinal forces, size-effect.
The main directions for further research of the issue are identified and recommendations are given that summarize domestic and foreign experience.
EVALUASI SISTEM PENYIMPANAN ALAT KESEHATAN DI SALAH SATU PEDAGANG BESAR FARMASI (PBF) DI KOTA BANDUNG
Authors: Adira Rahmawaty 
Published: August 2023

Medical devices are instruments, apparatus, machines, and/or implants that do not contain drugs that are used to prevent, diagnose, cure and alleviate disease, treat sick people, restore health to humans, and/or form structures and improve body functions whose distribution flow has been regulated in the Good Medical Devices Distribution Method. One aspect that needs attention in this Good Medical Devices Distribution Method is the medical device storage system. This study aims to evaluate the suitability of the medical device storage system at one of the Pharmaceutical Wholesalers in the city of Bandung with the existing regulations. The results of this study indicate that the medical device storage system at one of the Pharmaceutical Wholesalers in the city of Bandung is very compatible with the Good Medical Devices Distribution Method, even so there are several evaluations of overloaded medical device storage which are stored in the corridors of the medical device storage warehouse.
Keywords: Storage, Medical Devices, CDAKB
Evaluación de la difusividad térmica efectiva en el estado transitorio de una geometría fractal para condiciones de temperatura y flujo de calor constantes
Authors: Rosas Yescas Israel , Acosta Cano de los Ríos José Eduardo , Chávez López Óscar Arturo , Méndez Herrera Carlos Arturo , Ambríz Díaz Victor Manuel 
Published: August 2023

En este trabajo se comparan dos modelos para calcular la difusividad térmica efectiva usada en simulaciones de fenómenos transitorios con diferencias finitas de medios porosos con geometría fractal del tipo Alfombra de Sierpinsky. Se evalúa la coincidencia entre los resultados obtenidos utilizando estos modelos y simulaciones de elemento finito. Esta comparación se hace para dos condiciones: temperatura constante y flujo de calor constante y para diferentes valores de la porosidad. La simulación en elemento finito se hace utilizando el software Solidworks (SW) y las simulaciones con diferencias finitas utilizan el enfoque de equilibrio térmico local. Los resultados muestran que dependiendo del fenómeno a simular se puede utilizar alguno de los dos modelos. El modelo utilizado reproduce de manera adecuada el efecto de la porosidad en la evolución temporal de la temperatura, pero la distribución espacial no se ve afectada por este parámetro.
Cambio de color en las flores y producción asexual de semillas en Fuchsia thymifolia (Onagraceae)
Authors: Cervantes Díaz Cinthya Indira , Cuevas García Eduardo 
Published: August 2023

El cambio de color de las flores y la producción asexual de semillas (apomixis), son dos fenómenos poco estudiados en las angiospermas. En este trabajo estudiamos ambos fenómenos en Fuchsia thymifolia, una especie ginodioica en donde coexisten plantas hembra que únicamente producen flores femeninas y plantas con flores hermafroditas, en dos poblaciones naturales de Michoacán. Para estudiar el cambio de color de las flores, se marcaron botones florales en plantas hembra y hermafroditas, los cuales fueron censados y fotografiados diariamente. Para determinar la producción de semillas por apomixis, se utilizaron plantas hembra donde se excluyeron botones florales de los polinizadores y posteriormente se evaluó la producción de frutos. Encontramos que el cambio de color de las flores ocurre tanto en flores femeninas como hermafroditas y este cambio ocurre independientemente de que no fueran polinizadas. La coloración de las flores fue de blanco, cuando las flores abren a rosa durante el tercer y cuarto día y finalmente guinda en los últimos días de vida de las flores (día 5 a 7-8). Además, las flores femeninas fueron más longevas que las hermafroditas. En cuanto a la apomixis, en ambas poblaciones estudiadas y durante dos años, entre el 16 y 20% de las flores embolsadas produjeron frutos maduros. El cambio de color es similar al detectado en otras especies y en general la mayor coloración coincide con la ausencia de recompensas florales en las flores hermafroditas o con la pérdida de receptividad del estigma en las flores femeninas. En cuanto a la apomixis, se requiere de estudios moleculares que confirmen que las semillas obtenidas son genéticamente idénticas a las plantas hembra, como es de esperarse en este fenómeno.