bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel therapeutic management for diabetes patients with chronic limb-threatening ischemia: comparison of autologous bone marrow mononuclear cells versus allogenic Wharton jelly-derived mesenchymal stem cells
Authors: Arango-Rodríguez Martha L. , Mateus Ligia C. , Sossa Claudia L. , Becerra-Bayona Silvia M. , Solarte-David Víctor Alfonso , Ochoa Vera Miguel Enrique , Viviescas Lady T. Giratá , Berrio Ana M. Vera , Serrano Sergio Eduardo , Vargas Oliverio , Isla Andrés Catalá , Benitez Alape , Rangel Germán 
Published: August 2023

Abstract
Background
Chronic limb-threatening ischemia (CLTI) represents the final stage of peripheral arterial disease. Approximately one-third of patients with CLTI are not eligible for conventional surgical treatments. Furthermore, patients with advanced stage of CLTI are prone to amputation and death. Thus, an effective therapeutic strategy is urgently needed. In this context, autologous bone marrow mononuclear cell (auto-BM-MNC) and allogeneic mesenchymal stem cells represent a promising therapeutic approach for treating CLTI. In this study, we compared the safety and beneficial therapeutic effect of auto-BM-MNC versus allogeneic Wharton jelly-derived mesenchymal stem cells (allo-WJ-MSCs) in diabetic patients with CLTI.

Methods
We performed a randomized, prospective, double-blind and controlled pilot study. Twenty-four diabetic patients in the advanced stage of CLTI (4 or 5 in Rutherford’s classification) and a transcutaneous oxygen pressure (TcPO2) below 30 mmHg were randomized to receive 15 injections of (i) auto-BM-MNC (7.197 × 106 ± 2.984 × 106 cells/mL) (n = 7), (ii) allo-WJ-MSCs (1.333 × 106 cells/mL) (n = 7) or (iii) placebo solution (1 mL) (n = 10), which were administered into the periadventitial layer of the arterial walls under eco-Doppler guidance. The follow-up visits were at months 1, 3, 6, and 12 to evaluate the following parameters: (i) Rutherford’s classification, (ii) TcPO2, (iii) percentage of wound closure, (iv) pain, (v) pain-free walking distance, (vi) revascularization and limb-survival proportion, and (vii) life quality (EQ-5D questionnaire).

Results
No adverse events were reported. Patients with CLTI who received auto-BM-MNC and allo-WJ-MSCs presented an improvement in Rutherford’s classification, a significant increase in TcPO2 values‬, a reduction in the lesion size in a shorter time, a decrease in the pain score and an increase in the pain-free walking distance, in comparison with the placebo group. In addition, the participants treated with auto-BM-MNC and allo-WJ-MSCs kept their limbs during the follow-up period, unlike the placebo group, which had a marked increase in amputation.

Conclusions
Our results showed that patients with CLTI treated with auto-BM-MNC and allo-WJ-MSCs conserved 100% of their limb during 12 months of the follow-up compared to the placebo group, where 60% of participants underwent limb amputation in different times. Furthermore, we observed a faster improvement in the allo-WJ-MSC group, unlike the auto-BM-MNC group.
Trial registration This study was retrospectively registered at ClinicalTrials.gov (NCT05631444).
Sex differences in long-term kidney fibrosis following neonatal nephron loss during ongoing nephrogenesis
Authors: Menendez-Castro Carlos , Cordasic Nada , Fahlbusch Fabian B. , Woelfle Joachim , Hilgers Karl F. , Hartner Andrea 
Published: August 2023

Abstract
Background
Clinical studies suggest that female sex plays a protective role in the development and progression of kidney disease. Recent experimental studies indicate that in male rats early nephron loss under ongoing nephrogenesis is accompanied by severe long-term sequelae. In humans, nephron formation occurs mainly in the third trimester, ceasing with 36 weeks of gestation. Due to perinatal complications, preterm infants delivered during this vulnerable period may undergo acute nephron loss. In rats nephrogenesis persists until postnatal day 10, reflecting the situation of human preterms with persisting nephrogenesis. In our animal model of neonatal uninephrectomy, female and male rats were uninephrectomized at day 1 of life. Hypothesizing sex-dependent differences, long-term renal outcome was assessed after 1 year.

Results
In both sexes, neonatal uninephrectomy was not followed by arterial hypertension at 1 year of age. Compensatory weight gain and glomerular hypertrophy of the remaining kidney occurred in uninephrectomized female and male animals. Selected markers of interstitial inflammation and fibrosis were regulated sex-dependently. The expression of monocyte chemoattractant protein-1 was increased in females, while tubulointerstitial infiltration by M1 macrophages was significantly higher in males after neonatal uninephrectomy. Neonatally uninephrectomized male rats had more glomerulosclerosis and podocyte damage compared to females, which was assessed by a semiquantitative score and desmin staining. RT-PCR revealed that after neonatal uninephrectomy in the remaining contralateral kidney of female rats the expression of candidate genes of renal development and function, i.e., wt-1, nephrin, synaptopodin, gdnf, and itga8 was higher than in males.

Conclusions
Based on these observations we conclude that female sex is protective in the long-term response of the kidney to acute nephron loss under active nephrogenesis.
Review of the genus Sparasion Latreille, 1802 (Hymenoptera: Platygastroidea: Sparasionidae) of the Oriental region with descriptions of new species from India
Authors: Veenakumari Kamalanathan , Polaszek Andrew , Poggi Roberto , Sreedevi Kolla , Mohanraj Prashanth , Khan Farmanur Rahman , Baradevanal Gundappa 
Published: August 2023

Abstract
Background
The genus Sparasion, endoparasitoids of Tettigoniidae, occur in the Nearctic, Palearctic, Afrotropical and Oriental regions. It is absent in the Neotropics and Australasia. Of the thirteen species found in the Oriental region only a single species is from India.

Results
Two new species groups - Sparasion bilahari species group and Sparasion manavati species group - are proposed for species from the Oriental region. Thirty-six species are described and illustrated of which twenty-four are new: Sparasion albopilosellus Cameron, 1906 (Pakistan); S. bhairavi Veenakumari, sp. n. (India); S. bhupali Veenakumari, sp. n. (India); S. bihagi Veenakumari, sp. n. (India); S. bilahari Veenakumari, sp. n. (India); S. cellularis Strand, 1913 (Taiwan); S. coconcus Kozlov and Lê, 2000 (Vietnam); S. coeruleus Kieffer, 1905 (Sumatra); S. cullaris Kozlov and Lê, 2000 (Vietnam); S. darbari Veenakumari, sp. n. (India); S. deepaki Veenakumari, sp. n. (India); S. domes Kozlov and Lê, 2000 (Vietnam); S. elbakyanae Veenakumari, sp. n. (India); S. formosus Kieffer, 1910 (Taiwan); S. hindoli Veenakumari, sp. n. (India); S. kalyani Veenakumari, sp. n. (India); S. kanakangi Veenakumari, sp. n. (India); S. karivadana Veenakumari, sp. n. (India); S. lividus Johnson, Masner & Musetti, 2008 (Philippines); S. manavati Veenakumari, sp. n. (India); S. meghmalhari Veenakumari, sp. n. (India); S. micromerus Kozlov and Lê, 2000 (Vietnam); S. pahadi Veenakumari, sp. n. (India); S. philippinensis Kieffer, 1913 (Philippines); S. ratnangi Veenakumari, sp. n. (India); S. rupavati Veenakumari, sp. n. (India); S. salagami Veenakumari, sp. n. (India); S. shulini Veenakumari, sp. n. (India); S. sinensis Walker, 1852 (China); S. sivaranjini Veenakumari, sp. n. (India); S. syamalangi Veenakumari, sp. n. (India); S. todi Veenakumari, sp. n. (India); S. travancoricus Mani and Sharma, 1981 (India); S. vanaspati Veenakumari, sp. n. (India); S. visvambari Veenakumari, sp. n. (India) and S. zeelafi Veenakumari, sp. n. (India). Keys to Oriental species of Sparasion are furnished. Intrasexual colour morphs among females of Sparasion is reported. Lectotype is designated for Sparasion cellularis Strand.

Conclusions
Twenty-four new species are added to the Indian fauna of Sparasion. Previously described species of Oriental Sparasion are redescribed and illustrated. Keys are furnished for all Oriental species.
Spicy Shiro flour and Berbere powder (an ethnic, indigenous food of Ethiopia)
Authors: Zeru Tesfaye , Awoke Temesgen , Assefa Teshome , Tesfaye Biniyam , G/Giorgies Taddesse , Bitew Abebe , Taddesse Chere , Tesfaye Kelemua , Demelash Yoseph , Yehualashet Asrat , Tefera Nahom , Ashenafi Nigat , W/Yohannes Messeret , Legesse Addisu , Gobene Waqtole , Abera Andinet , Andualem Misganaw , Tessema Masresha 
Published: August 2023

AbstractEthiopia is a multiethnic nation with a wide range of cultural traditions, as well as ancient indigenous culinary skills that have made a significant contribution to national and religious holidays, family get-togethers, community celebrations, funeral rites, and economical progress. The most extensively produced and consumed traditional meals in various regions of Ethiopia are Shiro flour and Berbere powder. The significance and reputation of Shiro flour and Berbere powder in Ethiopian culture cannot be overstated. Shiro flour and Berbere powder are consistently the most well-liked and essential components in Ethiopian cuisine. However, research on Shiro flour and Berbere powder was limited, and there was no scientifically compiled data on these food products. As a result, this study was undertaken to collect indigenous knowledge, practices, mode of preparations, and skills, as well as to generate baseline data on Shiro flour and Berbere powder at the national level by examining the physicochemical qualities, this study was conducted. A cross-sectional study design was used, and 220 respondents with prior experience preparing Spicy Shiro flour and Berbere powder took part. The findings of this study will use for interventions such as food supplementation, importing to international markets for revenue generation, setting national and international standards, formulating products, providing students and researchers with reference material, and creating jobs, particularly for young people and women. The bioavailability and recommended amount/dosage of herbs and spices to be added during Shiro flour and Berbere powder preparation, however, has not been studied in Ethiopia. Furthermore, the current study did not address the analysis of antioxidants, aflatoxins content from Berbere powder, amino acid profiles, value addition, and shelf life of both products.
The robust $$H_{\infty }$$ control of stochastic neutral state delay systems
Authors: Ravi Kumar Rajagounder , Naveen R. , Anandhi V. , Sudha A. 
Published: August 2023

AbstractIn this paper, the resilient stochastic neutral state delay system with the Markov chain problem is examined. It offers output feedback control based on discrete state space delay and uncertainty that appear under traditional delay-independent conditions and exist under neutral stochastic state delays. Lyapunov theory can be used to solve the formulation $$x_c(t)=x(t)-Cx(t-\tau )$$

x
c

(
t
)

=
x

(
t
)

-
C
x

(
t
-
τ
)

for the intended $$H_\infty$$

H
∞

control of a stochastic model. Its stochastically mean square stability is shown using linear matrix inequalities (LMIs). The efficiency of the suggested strategy is shown by simulation results.
Prevalence and Risk Factors for Moral Distress in Pediatric Oncology Health Care Professionals
Authors: Mathews Natalie , Alodan Khalid , Kuehne Nathan , Widger Kimberley , Locke Maria , Fung Karen , Gandhi Sheila , McLean Jennifer , Hossain Alomgir , Alexander Sarah 
Published: August 2023

PURPOSE Moral distress (MoD) is prevalent among health care professionals (HCPs) in oncology and is associated with burnout. The objectives of this study were to quantify MoD among pediatric oncology healthcare professionals (HCPs) at a Canadian quaternary care hospital, identify root causes, and evaluate change over time. METHODS Eligible pediatric oncology HCPs were identified, and consenting participants completed the Measure of Moral Distress-Healthcare Professionals (MMD-HP) and MoD Thermometer (MDT) at baseline, followed by biweekly MDTs over 12 weeks. RESULTS A total of 139 HCPs participated. The mean MMD-HP score was 123 ± 57.0, range 9-288. Demographic risk factors identified for elevated MMD-HP scores were female sex (female 127.1 and male 83.6, P = .01) and nursing role (nurse 136.3 and most responsible physician 85.3, P = .02). Higher MMD-HP scores were found in HCPs who were currently considering resigning because of MoD compared with those who were not (169.9 v 115.4, P < .001). Situations involving administration of treatment to children with poor prognosis cancers that was perceived to be overly aggressive were ranked as the greatest environmental contributor to MoD. Baseline and mean MDT scores over time strongly correlated with MMD-HP scores ( P < .0001 and P = .0003, respectively), with mean MDT scores showing no significant fluctuation over the 12-week period. CONCLUSION MoD was common among pediatric oncology HCPs. Risk factors for elevated levels of MoD included both demographic and environmental factors. Implementation of systems to improve team communication and decision making, especially in the care of patients with poor prognosis cancers, may affect HCP MoD.
Efficacy of Immune Checkpoint Inhibition and Cytotoxic Chemotherapy in Mismatch Repair-Deficient and Microsatellite Instability-High Pancreatic Cancer: Mayo Clinic Experience
Authors: Coston Tucker , Desai Aakash , Babiker Hani , Sonbol Mohamad Bassam , Chakrabarti Sakti , Mahipal Amit , McWilliams Robert , Ma Wen Wee , Bekaii-Saab Tanios S. , Stauffer John , Starr Jason S. 
Published: August 2023

PURPOSE Pancreatic cancer (PC) carries a poor prognosis with high rates of unresectable/metastatic disease at diagnosis, recurrence after resection, and few systemic therapy options. Deficient mismatch repair (dMMR)/high microsatellite instability (MSI-H) PCs demonstrated uncharacteristically poor outcomes in KEYNOTE-158, evaluating pembrolizumab in MSI-H solid tumors. Our study aggregates the Mayo Clinic experience with dMMR/MSI-H PCs, characterizing the clinical, molecular, and treatment response patterns with a focus on response to immune checkpoint inhibitors (ICIs). METHODS Retrospective data were collected from the electronic medical record from December 2009 to February 2023. Patients were included if they had a pathologically confirmed pancreatic malignancy and had (1) deficient expression of mismatch repair (MMR) proteins by tumor immunohistochemistry, (2) pathogenic mutation of MMR genes on genomic sequencing, and/or (3) MSI-H by polymerase chain reaction. RESULTS Thirty-two patients were identified for inclusion, with all stages of disease represented. Sixteen of these patients underwent surgery or chemoradiotherapy. Of these patients, uncharacteristically favorable responses were seen, with a recurrence rate of only 19% (n = 3) despite a median follow-up of 25 months. In the palliative setting, excellent responses to ICI were seen, with overall response rate (ORR) of 75% (20% complete response). Median time to disease progression was not reached. Response rates to cytotoxic chemotherapy in the palliative setting were poor, with 30% ORR and median time to progression of 4 months. We observed a high rate of discrepancy between MMR and MSI testing methods, representing 19% of the entire cohort and 26% of evaluable cases. CONCLUSION Our data argue for the preferential use of ICI over cytotoxic chemotherapy in any patient with dMMR/MSI-H PC requiring systemic therapy, including in the metastatic and adjuvant/neoadjuvant settings.
The upper temperature and hypoxia limits of Atlantic salmon (Salmo salar) depend greatly on the method utilized
Authors: Sandrelli Rebeccah M. , Gamperl A. Kurt 
Published: August 2023

ABSTRACT
In this study, Atlantic salmon were: (i) implanted with heart rate (fH) data storage tags (DSTs), pharmacologically stimulated to maximum fH, and warmed at 10°C h−1 (i.e. tested using a ‘rapid screening protocol’); (ii) fitted with Doppler® flow probes, recovered in respirometers and given a critical thermal maximum (CTmax) test at 2°C h−1; and (iii) implanted with fH DSTs, recovered in a tank with conspecifics for 4 weeks, and had their CTmax determined at 2°C h−1. Fish in respirometers and those free-swimming were also exposed to a stepwise decrease in water oxygen level (100% to 30% air saturation) to determine the oxygen level at which bradycardia occurred. Resting fH was much lower in free-swimming fish than in those in respirometers (∼49 versus 69 beats min−1) and this was reflected in their scope for fH (∼104 versus 71 beats min−1) and CTmax (27.7 versus 25.9°C). Further, the Arrhenius breakpoint temperature and temperature at peak fH for free-swimming fish were considerably greater than for those tested in the respirometers and given a rapid screening protocol (18.4, 18.1 and 14.6°C; and 26.5, 23.2 and 20.2°C, respectively). Finally, the oxygen level at which bradycardia occurred was significantly higher in free-swimming salmon than in those in respirometers (∼62% versus 53% air saturation). These results: highlight the limitations of some lab-based methods of determining fH parameters and thermal tolerance in fishes; and suggest that scope for fH may be a more reliable and predictive measure of a fish's upper thermal tolerance than their peak fH.
Factors Influencing Implementation of Youth Physical Activity Interventions: An Expert Perspective
Authors: Lau Erica Y. , Wandersman Abraham H. , Pate Russell R. 
Published: August 2023

ABSTRACT
Little is known about the factors that influence implementation of physical activity interventions undertaken in youth-serving settings, and this lack of information impedes the development of effective implementation strategies. This study convened a panel of experts to identify factors that are most important in achieving successful implementation of physical activity interventions in youth-serving organizations. Five recognized experts participated in a four-round, modified Delphi consensus process. The panelists were asked to achieve consensus on a list of potential factors that are most important in predicting successful implementation and on the descriptions of these factors. They also provided estimates regarding the individual contributions each of the identified factors make in predicting a successful implementation. These estimates were then translated into Bayesian predictive models for factor selection. The expert panel achieved consensus on 23 factors. Results from the factor selection procedures indicated that a final model containing 15 factors yielded the greatest contributions in predicting successful implementation of youth physical activity interventions. In this final model, five factors were classified as organizational characteristics, six factors as implementation processes, two factors as provider characteristics, and two factors as program characteristics and community-level factors, respectively. In conclusion, this is the first study to identify factors that are important in achieving a successful implementation of youth physical activity interventions through systemically gathering information from a panel of experts. The 15 factors identified in this study provide important information to inform implementation planning and evaluation of future interventions.
Clinical Research to Community Practice
Authors: Donnelly Joseph E. 
Published: August 2023

ABSTRACT
In April 2016, the American College of Sports Medicine launched a new journal, the Translational Journal of the American College of Sports Medicine. Translational research is difficult to define and means different things to different individuals. It is a bit analogous to the phrase “I can't define it but I know it when I see it.” However, the essence of translational science is the attempt to apply basic and clinical science findings to communities and populations. That is, take what is known and apply it to the real world.
Translational Gap between Laboratory and Playing Field: New Era to Solve Old Problems in Sports Science
Authors: Eisenmann Joey 
Published: August 2023

ABSTRACT
“Bridging the gap” and “science into practice” have long been themes in high-performance sports training, conditioning, and monitoring. Recently, parallel developments in sports science and translational science in the United States have perhaps set the stage for a new era to solve old problems. This article will discuss the trends in sports science in the United States, provide an overview of translational science and knowledge management, summarize and align existing translational science research models, address problems and potential solutions in the translational sports science framework, and provide examples of research that have translated sports science research into practice. The objectives of this article are to stimulate collaborations between academics and practitioners and to provide solutions for harmonizing integrated sports performance models.
Menstrual Dysfunction in Females Presenting to a Pediatric Sports Medicine Practice
Authors: Fischer Anastasia N. , Yang Jingzhen , Singichetti Bhavna , Young Julie A. 
Published: August 2023

ABSTRACT
This study aimed to determine the prevalence of menstrual dysfunction (MD) among injured female athletes presenting to a pediatric primary care sports medicine clinic and to examine the influence of type of injury (acute or overuse) and type of sports participation (i.e., lean build sports [LBS], non–lean build sports [NLBS], or combination [CBS]) on the likelihood of experiencing MD to recommend better screening practices for these athletes. Demographics and menstrual history were collected from females (10–18 yr) presenting with a new musculoskeletal injury, along with type of injury and participation in LBS (n = 156), NLBS (n = 243), or CBS (n = 92). Logistic regression models were used to determine the odds of MD, adjusting for age and body mass index. Of 491 females who met inclusion criteria for the study, 15.9% reported MD. Females experiencing MD were likely to be older at menarche (12.3 vs 11.9, P = 0.006), with a similar body mass index (P = 0.244). Female athletes experiencing an acute or overuse injury had a similar risk of experiencing MD (adjusted odds ratio [AOR] = 1.40, 95% CI = 0.85–2.28). Females who participated in LBS were as likely as those who participated in NLBS to have MD (AOR = 1.52, 95% CI = 0.86–2.66). However, participation in NLBS or CBS tended to protect injured females from MD as compared with sole LBS participation (AOR = 0.77, 95% CI = 0.46–1.29), although the relationship was not statistically significant. MD is prevalent in adolescent female athletes presenting with musculoskeletal injuries; however, it is not associated with the type of injury or type of sport in which the athlete participates. All adolescent females presenting with musculoskeletal injury should be screened for MD.