bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTAÇÃO DE UM PROTOCOLO DE CUIDADO FARMACÊUTICO EM IDOSOS HIPERTENSOS EM UMA FARMÁCIA COMUNITÁRIA DE JARAGUÁ DO SUL, BRASIL
Authors: Reis Ariella Ciana Ferreira Torres , Da Rosa Priscila Batista , Neis Vivian Binder 
Published: April 2023

O presente estudo teve como objetivo implementar um modelo de cuidado farmacêutico para monitoramento do tratamento medicamentoso de idosos hipertensos em uma farmácia comunitária no município de Jaraguá do Sul, SC, Brasil. Foi utilizado o Método Dáder para seguimento farmacoterapêutico de uma amostra aleatória simples de 15 indivíduos, de ambos os sexos, com idade entre 60 e 81 anos, diagnosticados com hipertensão. Os pacientes foram acompanhados por um período de três meses, nos quais foram aplicados questionários sobre hábitos de vida, história farmacoterapêutica, adesão ao tratamento além de identificar e classificar os problemas relacionados aos medicamentos (PRM). Em todos os encontros foram verificados os níveis pressóricos, para acompanhar o efeito dos fármacos prescritos. Ao final, foi possível observar que houve redução dos níveis pressóricos de dois de grau grave e um de grau moderado para leve, um com pressão arterial limítrofe atingiu o nível de normalidade e apenas um registrou aumento da pressão arterial passando de grau leve para moderado. Os PRM tipo 1 e 4 foram os mais detectados. As intervenções educativas foram priorizadas com enfoque na orientação sobre o uso correto dos medicamentos, além do esclarecimento de dúvidas sobre medidas não farmacológicas, como controle de peso, redução do consumo de álcool e sal. Esses resultados reforçam a importância do cuidado farmacêutico para melhora da qualidade de vida dos hipertensos, melhoria dos níveis pressóricos e controle de possíveis complicações decorrentes da doença ou do uso inadequado dos fármacos.
Response surface optimization and social impact evaluation of Houttuynia cordata Thunb solar drying technology for community enterprise in Chiangrai, Thailand
Authors: Kreetachat Torpong , Imman Saksit , Suwannahong Kowit , Wongcharee Surachai , Suriyachai Nopparat 
Published: April 2023

Drying has emerged as one of the most important ways of preserving high-quality and quantity food goods. A force convection solar drying is considered an ecologically and environmentally friendly alternative. This research presents parameter optimization of greenhouse tunnel dryer of Houttuynia cordata Thunb (H. cordata) using response surface methodology with the assessment of economic feasibility and social return on invesment. The influence parameters of the drying process were evaluated to obtain maximum efficiency. The individual parameters were temperature (40 – 60 °C), material length (10 – 30 cm), and relative humidity (30 – 50%). The individual parameters of drying temperature showed an extreme effect on the response of moisture content and color value change, while the relative humidity had only an influence on moisture content. On the other hand, the parameter of material length was not significance in both responses. When compared to open-air drying, solar drying reduced the drying time of H. cordata by 57.14%. The payback period of the dryer was found to be 2.5 years. Furthermore, the results reveal that the social return on investment ratio in 2021 was 2.18, then increasing to 2.52 in 2022 and 2.91 in 2023. According to the findings, solar drying technology has the potential to be an adequate product quality improvement technology for H. cordata. It is a feasible drying technology in terms of economic evaluation.
Mathematics First: Russell’s Methodological Response to Bradley
Authors: Spinney Oliver Thomas 
Published: April 2023

Abstract
In this article I examine the dispute between F. H. Bradley and Bertrand Russell concerning the reality of relations. I show that Bradley’s objections to Russell’s view, that there are such things as relations which serve to effect the unity of complex items, were rooted in a methodological approach which Russell did not share. On Bradley’s view, one must be able to offer reductive analyses of the items one postulates in order that commitment to those items be justified. I argue that Russell expressly rejected this methodological principle of Bradley’s, and instead adopted the view that one may justifiably postulate entities if doing so aids in the illumination of mathematical truths. I show that the postulation of relations does, on Russell’s view, serve to provide that illumination. Russell held that the truths of mathematics constitute fixed data, and that philosophical positions may be judged as successful according to the extent that they possess explanatory power with respect to this data. I argue that Bradley’s and Russell’s exchanges in print, as well as in private correspondence, reflect Russell’s awareness of a fundamental difference in methodological approach. I conclude that Russell elected not to answer Bradley’s objections on their own terms, but rather rejected the methodological assumptions from which those objections emerged.
Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury
Authors: Wang Changsheng , Zhu Xitian , Chen Rongsheng , Zhang Xiaobo , Lian Nancheng 
Published: April 2023

AbstractGene Expression Omnibus database shows significantly downregulated expression of ubiquitin protein ligase E3 component N-recognin 1 (UBR1) in spinal cord injury (SCI). In this study, we investigated the mechanism of action of UBR1 in SCI. Following the establishment of SCI models in rats and PC12 cells, Basso–Beattie–Bresnahan (BBB) score and hematoxylin-eosin (H&E) and Nissl staining were used to evaluate SCI. The localization of NeuN/LC3 and the expression of LC3II/I, Beclin-1, and p62 were detected to assess autophagy. The expression of Bax, Bcl-2, and cleaved caspase-3 was detected and TdT-mediated dUTP-biotin nick end-labeling staining was employed to determine the changes in apoptosis. The N(6)-methyladenosine (m6A) modification level of UBR1 was analyzed by methylated RNA immunoprecipitation, and the binding of METTL14 and UBR1 mRNA was analyzed by photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation. UBR1 was poorly expressed, and METTL14 was highly expressed in rat and cell models of SCI. UBR1 overexpression or METTL14 knock-down enhanced motor function in rats with SCI. Moreover, this modification increased Nissl bodies and autophagy and inhibited apoptosis in the spinal cord of SCI rats. METTL14 silencing reduced the m6A modification level of UBR1 and enhanced UBR1 expression. Importantly, UBR1 knock-down nullified METTL14 knock-down-induced autophagy promotion and apoptosis reduction. The METTL14-catalyzed m6A methylation of UBR1 promoted apoptosis and inhibited autophagy in SCI.
Rescue of Long-Term Spatial Memory by 7,8-Dihydroxyflavone in Mice with Reduced Oligodendrogenesis
Authors: Rawlings-Mortimer Florence , Johansen-Berg Heidi 
Published: April 2023

AbstractOligodendrogenesis is the process by which new oligodendrocytes are produced in the CNS. Oligodendrocytes form myelin, which has a vital role in neural signal transmission and integration. Here we tested mice with reduced adult oligodendrogenesis in the Morris water maze, a test of spatial learning. These mice were found to have impaired long-term (28 d) spatial memory. However, when 7,8-dihydroxyflavone (7,8-DHF) was administered immediately after each training session, their long-term spatial memory impairment was rescued. An increase in the number of newly formed oligodendrocytes in the corpus callosum was also observed. 7,8-DHF has previously been shown to improve spatial memory in animal models of Alzheimer’s disease, post-traumatic stress disorder, Wolfram syndrome and Down syndrome, as well as in normal aging. Understanding the underlying mechanisms of the effect of this drug on spatial memory is therefore helpful in assessing it for clinical relevance and development.
Mandatory Metal Moments
Authors: Rossetti Gregory 
Published: April 2023

Through a series of case studies, this article presents a framework of common musical tropes originally only found in heavy metal music. The use of aggressive “double-kick” drum grooves, galloping bass lines, harmonized melodies, and overall fast tempi are all common elements of many styles of metal that first emerged in the 1980s. Video games developed alongside this musical genre; action, platforming, and role-playing games not only embraced these distinguishing characteristics of metal music, but these tropes are now expected in games of various genres. In addition, other extra-musical topics associated with heavy metal’s lyrical themes—such as references to the occult and fantasy—are common archetypes used to build the worlds of these video games.
Studies have been conducted that examine the cultural similarities between these two cultures, the relationship of music genre with game genre and function, and the use of rock paired with sacred music specifically in battle themes. By analyzing the arrangements, treatment of melodic contours, rhythmic gestures, and harmonic progressions of these games, this article discusses and demonstrates how metal has disseminated into video game culture. There are strong connections between the fast-paced obstacles in Mega Man with the speed of Iron Maiden, the gothic horror stages of Castlevania and Baroque elegance of Yngwie Malmsteen, and how the themes from fantasy literature made their way into video game design and power metal. The worlds of these games are built on their music, but their music is built on a fusion of tropes used in heavy metal culture.
Multi‐omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer
Authors: Stentenbach Maike , Ermer Judith A , Rudler Danielle L , Perks Kara L , Raven Samuel A , Lee Richard G , McCubbin Tim , Marcellin Esteban , Siira Stefan J , Rackham Oliver , Filipovska Aleksandra 
Published: April 2023

AbstractProstate cancer is the most commonly diagnosed malignancy and the third leading cause of cancer deaths. GWAS have identified variants associated with prostate cancer susceptibility; however, mechanistic and functional validation of these mutations is lacking. We used CRISPR‐Cas9 genome editing to introduce a missense variant identified in the ELAC2 gene, which encodes a dually localised nuclear and mitochondrial RNA processing enzyme, into the mouse Elac2 gene as well as to generate a prostate‐specific knockout of Elac2. These mutations caused enlargement and inflammation of the prostate and nodule formation. The Elac2 variant or knockout mice on the background of the transgenic adenocarcinoma of the mouse prostate (TRAMP) model show that Elac2 mutation with a secondary genetic insult exacerbated the onset and progression of prostate cancer. Multiomic profiling revealed defects in energy metabolism that activated proinflammatory and tumorigenic pathways as a consequence of impaired noncoding RNA processing and reduced protein synthesis. Our physiologically relevant models show that the ELAC2 variant is a predisposing factor for prostate cancer and identify changes that underlie the pathogenesis of this cancer.
Mixobarbaros – mixobarbaroi •
Authors: Farkas Zoltán 
Published: April 2023

ABSZTRAKTA dolgozat Gyóni Mátyás Paristrion bizánci thema XI. századi történetéről és az Alexiasban előforduló népnevekről szóló tanulmányából kiindulva új megközelítésben vizsgálja az idézett forrásokat. A μιξοβάρβαρος szó történetét a klasszikus kortól nyomon követve megállapítja, hogy a mellék nevet eredetileg a görög világ peremvidékén fekvő városok (görög és barbár) lakosságára, majd a nem (attikai) görög nyelvre, később a kerülendő és (erkölcsileg) elítélhető jelenségek és személyek, végül a nem orthodox keresztények minősítésére használták. A XI–XIII. századi bizánci szerzők is általában megbélyegzésként használták a melléknevet. Michaél Attaleiatés klasszikus helyén viszont a melléknév semleges tartalmú, használata két klasszikus szerző nyelvhasználatával (Plat. 245d; Xen. Hell. 2, 1, 5) egyező, azzal a különbséggel, hogy a mixobarbaroi (ODB s. v.) nem egyetlen város, hanem egy adott térség, Paristrion (városainak) kevert lakosságát jelöli. Anna Komnéné művében a szóhasználat egyedi, amenynyiben a kettős származású (feltehetően vegyes házasságból származó) μιξοβάρβαρος legfontosabb jellegzetessége az, hogy kétnyelvű.
Políticas de recursos humanos a través de los códigos éticos de multinacionales españolas
Authors: López-Crespo Francisco Javier , Marqués-Pascual Joaquín , Fondevila-Gascón Joan Francesc 
Published: April 2023

Potenciar la marca mediante la propuesta de valor al empleado (EVP) es la estrategia de las empresas para captar y fidelizar a sus profesionales. Tomando los códigos éticos (CE) como principal documento donde se promulga el ethos corporativo. Se analiza la ética del management de la EVP de las empresas del IBEX 35 (índice selectivo del mercado de valores español). Mediante una metodología mixta se triangula un análisis de contenido temático de sus CE, contabilizando el peso que las sociedades dan a las principales áreas de la EVP. Se concluye que la mayoría de las empresas comunican al menos tres: afiliación, contenido del trabajo y desarrollo profesional, por lo que la marca empleadora que transmiten es incompleta ya que las áreas de compensación y beneficios están subrepresentadas. Destacan: desarrollo del talento, valores, condiciones de trabajo y, seguridad y salud, todos acordes a las teorías del bienestar laboral y del engagement.
Expression profile of plasma microRNAs and target genes in patients with complicated pregnancy
Authors: Pashkovsky D. G. , Solovieva E. V. , Rabadanova Ts. R. , Gorbunova P. T. , Dubovaya A. B. , Muslimova E. R. , Khoroz E. E. , Karabash Z. S. , Sorokina L. E. 
Published: April 2023

Aim: comparative analysis of the expression profile of plasma microRNAs and target genes in patients with complicated pregnancy.Materials and Methods. A prospective observational comparative study in parallel groups was carried out. The study included 73 women divided into three groups: the main group – 42 patients with preeclampsia (PE), the comparison group – 12 pregnant women with fetal growth retardation (FGR), the control group – 19 clinically healthy women with uncomplicated pregnancy. An examination was performed, which included the analysis of clinical characteristics and the study of microRNA expression in blood plasma using the real-time polymerase chain reaction.Results. MicroRNA hsa-miR-210-5p and hsa-miR-1972 were not identified in any plasma sample. Analyzing plasma microRNAs in group of women with PE showed significant changes in the expression levels of hsa-miR-517a-3p (p = 0.025), hsa-miR-517c-3p (p = 0.036), hsa-miR-574-5p (p = 0.015), hsa-miR-517a-3p (p < 0.001) and an increase in miR-20a-5p (p = 0.046) compared to control group. No significant differences were found in the miRNA expression profile in group of women with FGR compared to control group. Assessing an influence of the studied microRNAs on regulatory signaling pathways allowed to establish that hsa-miR-miR-146a-5p, -181a-5p, -210-3p, -517a-3p, -517c-3p, -574-3p, -574-5p, -1304-5p are potential regulators of the reaction cascades involved in the PE pathogenesis.Conclusion. The changes revealed in the circulating blood plasma miRNA level indicate the presence of specific transcriptomic alterations during complicated course of pregnancy.
Comparision between functional outcome of scaphoid fracture treated by open reduction internal fixation vs percutaneous fixation
Authors: Patel Jaydeep , Dinkar K S , Kapoor Rajat , Verma Ajay , Dwivedi Saurabh , Pal C P , Verma Ashutosh 
Published: April 2023

Scaphoid bone fracture is one of the commonest carpal bone fractures. It is predominantly seen in young population. Unstable or displaced scaphoid fractures can be treated either by primary use of cast immobilization alone, by use of Open Reduction Internal Fixation (ORIF) technique or by percutaneous fixation with Herbert screw under direct C arm fluoroscopic guidance. This study aims to review clinical, radiological and function outcome following ORIF technique Vs Percutaneous Fixation Technique in scaphoid fractures.Cases of acute scaphoid fractures who came to our department and met inclusion and exclusion criterias were identified and included in this study. Clinical details of these patients were obtained and scaphoid radiographs were taken. Injuries were graded as per Herbert and Fisher Classification. All our cases underwent grip-strengthening exercises and relevant physiotherapy Clinico-radiological details of our cases were obtained at each follow-up. Final follow-up of our cases was performed using Modified Mayo Wrist Score (MMWS). Grip strength was graded as per Medical Research Council (MRC) scale and range of motion was assessed using goniometer.A total of 40 cases were enrolled in our study. 16 patients (40% cases) underwent percutaneous herbert screw fixation and rest of our cases underwent open reduction and internal fixation. Radiological union in cases treated with percutaneous fixation was faster as compared to cases treated by ORIF. Also patients treated with percutaneous method demonstrated higher mean range of motion score, mean grip strength score and activity score.In our study excellent results have been obtained in cases treated with percutaneous approach in terms of post-operative morbidity and this approach also allows earlier return to sports and work thereby necessitating importance of this approach over ORIF approach in a developing resource poor country like India.
Functional outcome of the intertrochanteric fracture of femur managed by Dynamic hip screw and proximal femoral nail: A prospective comparative study
Authors: Kumar Mithilesh , Kumar Vinod 
Published: April 2023

Intertrochanteric fractures are among the most common hip fractures, particularly in the elderly with osteoporotic bones, and are typically caused by low-energy trauma such as simple falls. Although PFN and DHS have been used to treat intertrochanteric fractures, the results and conclusions are inconsistent. The present Prospective Comparative study was conducted at the Department of Orthopaedics, MSDASMC, Bahraich, over 24 months, from June 2019 to June 2021. Intertrochanteric fractures were treated randomly, whether using the Dynamic Hip Screws (DHS) or the proximal femoral nail (PFN). Out of a total of 60 cases, all of them were included. A group of 30 patients was separated into two groups: the first group received 30 Dynamic Hip Screws, while the second group had 30 PFN. Every patient was followed for nine months after their treatment. In our study, the mean Age in the PFN group was 62.5 ± 4.26, while in the DHS group, it was 63.7 ± 3.78 years. In the present study, a higher Harris Hip score (HHS) was observed in PFN groups. Their intergroup comparison of Harris Hip score between PFN and DHS group revealed significant differences at each follow-up. Furthermore, the minimal blood loss, duration of surgery, and incision size was low in the PFN group, and the difference was statistically significant compared to the DHS group. Mean hospital stay also showed no significant differences. In the intertrochanteric fracture of the femur, the PFN is a more suitable fixation approach. To the extent that it will further the generalizability and dependability of the research, the demand will be granted.
Osteochondroma of rib: A case report
Authors: Chandge Abhijit , Kulkarni Narendra D , Chandge Ashish M 
Published: April 2023

Osteochondroma is the most common benign tumor of bone, occurring either as an isolated lesion or in the context of hereditary multiple exostoses. In both cases, osteochondroma can arise from the ribs, and is often asymptomatic. In fact, the diagnosis often follows the onset of serious complications either from mechanical interference with the neighboring anatomical structures, or from malignant degeneration., We present a case of swelling over right side of chest wall in 40 year old male patient. X-ray and CT scan showed bony swelling over right ninth rib. Tumor was resected to avoid future complication. Subsequently, histological examination confirmed the diagnosis of osteochondroma and showed the lack of dysplastic changes. Various studies have shown that the surgical resection of osteochondroma is necessary in adults to avoid future complications of haemothorax, pneumothorax, intercostals neuralgia and malignant transformation, hence we resected tumor in this case.
In vivo efficiency of the produced recombinant lysostaphin antimicrobial peptide in treatment of methicillin-resistant Staphylococcus aureus (MRSA) skin infection in a mouse model
Authors: Abbasian Shabnam Sadoogh , Ghaznavi-Rad Ehsanollah , Sadelaji Samira , Abtahi Hamid 
Published: April 2023

Background and Objectives: Staphylococcus simulans secretes an antimicrobial compound called lysostaphin, which has bactericidal properties. It destroys staphylococci through the hydrolysis of peptidoglycan in the cell wall. Therefore, this unique property indicates the high ability of lysostaphin in the treatment of staphylococcal infections and is considered as an anti-staphylococcal agent.
Materials and Methods: Escherichia coli BL21 (DE3) competent cells were transformed with pET32a-lysostaphin clone and induced by isopropyl-β-D-thio-galactoside (IPTG). The recombinant protein was purified by affinity chromatography. Recombinant lysostaphin -A-based ointment was used for external wound healing in animal model. In vivo activity of oint- ment was evaluated by clinical evidences and cytological microscopic assessment.
Results: Our results showed the recombinant protein was produced exactly. The results of checkerboard tests showed MIC, MBC and antibacterial activity test an acute reduction of cell viability during the use of lysostaphin, and SEM results ap- proved the intense wrecking effects of lysostaphin in combination on bacterial cells. Macroscopic findings and microscopic data showed that the recombinant lysostaphin ointment was effective on excisional wound healing.
Conclusion: Our findings proved that the recombinant lysostaphin ointment was effective on wound healing due to Staphy- lococcus aureus infection.