bluuebunny/crossref_metadata_2025_split huggingface dataset:
cytoviewer:an R/Bioconductor package for interactive visualization and exploration of highly multiplexed imaging data
Authors: Meyer Lasse , Eling Nils , Bodenmiller Bernd 
Published: May 2023

AbstractSummaryHighly multiplexed imaging enables single-cell-resolved detection of numerous biological molecules in their spatial tissue context. Interactive data visualization of multiplexed imaging data is necessary for quality control and hypothesis examination. Here, we describecytoviewer, an R/Bioconductor package for interactive visualization and exploration of multi-channel images and segmentation masks. Thecytoviewerpackage supports flexible generation of image composites, allows side-by-side visualization of single channels, and facilitates the spatial visualization of single-cell data in the form of segmentation masks. The package operates onSingleCellExperiment, SpatialExperimentandCytoImageListobjects and therefore integrates with the Bioconductor framework for single-cell and image analysis. Users ofcytoviewerneed little coding expertise, and the graphical user interface allows user-friendly navigation. We showcase the functionality ofcytoviewerby analysis of an imaging mass cytometry dataset of cancer patients.AvailabilityThecytoviewerpackage can be installed from Bioconductor viahttps://www.bioconductor.org/packages/release/bioc/html/cytoviewer.html. The development version and further instructions can be found on GitHub athttps://github.com/BodenmillerGroup/cytoviewer. We provide an R script to exemplify the usage ofcytoviewerin the supplementary information.Supplementary informationsSupplementary data are available online.
YAP/TAZ are Crucial Regulator of Macrophage-mediated Pulmonary Inflammation and Fibrosis after Bleomycin-induced Injury
Authors: Mia Masum M. , Abdul Ghani Siti Aishah Binte , Cibi Dasan Mary , Bogireddi Hanumakumar , Wong Wai Shiu Fred , Singh Manvendra K. 
Published: May 2023

AbstractPulmonary fibrosis (PF) is the most common form of end stage interstitial devastating lung disease characterized by the scarring of lung due to excessive production of extracellular matrix (ECM). Recent studies have revealed the impact of macrophages in inflammation-induced fibrosis and distinct subsets of macrophages differentially contributes to the development of PF. However, the regulatory mechanisms and proinflammatory/profibrotc behaviour of heterogeneous population of lung macrophages during fibrogenesis remain incompletely understood. Here, we demonstrate the macrophage-specific role of Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in the development of bleomycin-induced inflammation and PF in mice. Both YAP/TAZ are activated in lung macrophages of fibrotic patients and of mice after bleomycin-induced injury. Myeloid-specific genetic deletion ofYap/Tazresulted in reduced recruitment of monocyte-derived alveolar macrophages (Mo-AMs), leading to an impaired inflammatory response, reduced PF and improved regeneration of alveolar epithelial cells in bleomycin-injured lung. However, overexpression ofYapin macrophages augmented the Mo-AMs recruitment in lung leading to increased proinflammatory response, exacerbated fibrotic response and decreased regeneration of alveolar epithelial cells in bleomycin-injured lung. We demonstrate that YAP/TAZ regulate PF through the activation of macrophage recruitment driver C-C motif chemokine ligand 2 (CCL2) and blocking of CCL2 with neutralizing antibody prevented YAP-induced inflammatory and fibrotic response. We also demonstrate that YAP/TAZ regulate macrophage polarization as well as macrophage-fibroblasts crosstalk by regulating expression of Methyl-CpG–binding domain 2 (MBD2) during bleomycin-induced PF. Taken together, we show that YAP/TAZ are potent regulators of macrophage polarization, infiltration and macrophage–mediated proinflammatory/profibrotic response during PF.
Method to detect the bolt thread defect in the aerospace vehicle with ultrasonic image and its implementation
Authors: Liu Chunhua , Li Ming , Chen Peng , Zhang Chaoyun 
Published: May 2023

Purpose
This study aims to solve the problems of ambiguous localization, large calculation, poor real-time and limited applicability of bolt thread defect detection.

Design/methodology/approach
First, the acquired ultrasound image is used to acquire the larger area of the image, which is set as the compliant threaded area. Second, based on the determined coordinates of the center point in each selected region, the set of coordinates on the left and right sides of the bolts is acquired by DBSCAN method with parameters eps and MinPts, which is determined by data set dimension D and the k-distance curve. Finally, the defect detection boundary line fitting is completed using the acquired coordinate set, and the relationship between the distance from each detection point to the curve and d, which is obtained from the measurement of the standard bolt sample with known thread defect, is used to locate the bolt thread defect simultaneously.

Findings
In this paper, the bolt thread defect detection method with ultrasonic image is proposed; meanwhile, the ultrasonic image acquisition system is designed to complete the real-time localization of bolt thread defects.

Originality/value
The detection results show that the method can effectively detect bolt thread defects and locate the bolt thread defect location with wide applicability, small calculation and good real-time performance.
Estimation of the wind drift factor and uncertainty analysis based on CFD computer simulations
Authors: Sbragio Ricardo , Martins Marcelo Ramos 
Published: May 2023

PurposeThe purpose of this work is to present a procedure for determining the wind drift factor through two-dimensional computational fluid dynamics (CFD) simulations of the wind acting on a wavy sea surface, such that the subjectivity of its estimation is reduced.Design/methodology/approachThe wind drift factor was determined by two-dimensional CFD analyses with open-channel condition. The characteristic wave was determined by the Sverdrup–Munk–Bretschneider (SMB) method. The uncertainty analysis is based on convergence studies using a single parameter refinement (grid and time step).FindingsThis procedure allows the estimation of the wind drift factor in a fetch-limited domain. The domain's value in the analyzed region is 0.0519 ± 4.92% which is consistent with the upper values of the wind drift factors reported in the literature.Research limitations/implicationsThe use of a three-dimensional domain was impractical with the available computational resources because of the fine mesh required for wave modeling. The uncertainty analysis consisted only of a verification procedure. Validation against real data was not possible because of the lack of measured data in the analyzed region.Originality/valueThe wind drift factor is usually estimated based on either experience or random sampling. The original contribution of this work is the presentation of a CFD procedure for estimating the wind drift factor, in which the domain inlet is subjected to a wave boundary condition and to a wind velocity.
The impact of energy certificates on sales and rental prices: a comparative analysis
Authors: Gerassimenko Alesia , Defau Laurens , De Moor Lieven 
Published: May 2023

Purpose
The current literature on energy certificates shows that Energy Performance Certificate labels have an important effect on real estate prices. However, interestingly, the limited studies that address the rental market find significantly lower price premiums than the sales market. The purpose of this paper is to add to this literature, by doing a comparative analysis of price premiums in the sales and rental market in Flanders (Belgium).

Design/methodology/approach
This study uses a hedonic regression model to analyze 177,670 real estate listings between 2016 and 2021. The data is provided by Immoweb – the largest online real estate platform in Belgium. The data set was divided in sold and rented properties: the authors evaluated 126,217 sales listings and 51,453 rent listings.

Findings
The results confirm that energy efficient properties generate a price premium, but that this premium is significantly larger in the sales market than in the rental market. In addition, the findings indicate that both investors and landlords could benefit strongly from renovating dwellings – especially when renovating from an F label to an A label.

Originality/value
Previous research focuses strongly on the sales market, although in many countries the rental market is similar in size and responsible from much energy consumption. Interestingly, the few studies that are addressing the rental market, find singificantly smaller price premiums than in the sales market. The findings add to this literature tradition and offer a comparative analysis of price premiums in the sales and rental market in Flanders. This allows us to not only show the similarities between both markets but also highlight the differences – creating valuable insights for academia, governments and real estate professionals.
Adult safeguarding in Ireland: a critical review of context and gaps
Authors: Phelan Amanda 
Published: May 2023

Purpose
The purpose of this paper is to critically review the context of adult protection in Ireland with a focus on older people. The paper traces advances and current limitations in policy, regulation, practice and legislation.

Design/methodology/approach
A review of historical and current contexts in adult safeguarding in Ireland is presented with consideration of key public reviews and commentaries related to care provision, governance and the legislative status of adults at risk.

Findings
While Ireland’s journey to provide adult safeguarding responses for older people has progressed since 2002, there remain many gaps. Further work needs to be addressed urgently to enable a comprehensive alignment of fit-for-purpose, responsive legislation, practice and policy to meet the complex and diverse needs of an increasing ageing population who may require safeguarding support. This includes fostering robust inter-sectorial collaboration, safeguarding legislation and cultural change related to human rights approaches.

Research limitations/implications
The paper is a discussion on the context of adults safeguarding in relation to practice, policy and legislation.

Practical implications
Identifies the need for significant reform in the Irish system of health service. Argues for an overarching, inter-sectorial approach to addressing adult safeguarding, which focuses on prevention as well as early intervention.

Originality/value
The paper offers a review of the current diverse elements comprising current adult safeguarding and older people in Ireland and integrates legislative, regulatory, policy and practice realities. Challenges are illustrated within the context of reactive rather than proactive safeguarding agendas which are linked to public scandals and debates. The paper argues for a more integrated and robust inter-sectorial approach to safeguarding underpinned by adult safeguarding legislation and an overarching governance structure.
The African continental free trade area: the road ahead for the continent’s bold integration project
Authors: Hagos Bereket Alemayehu 
Published: May 2023

Purpose
This paper aims to examine the road ahead for the African Continental Free Trade Area (AfCFTA), focusing on its potential opportunities and challenges. It is intended to help the AfCFTA’s effective implementation by highlighting the major areas of intervention for State Parties.

Design/methodology/approach
The paper analyses relevant economic, political and legal research sources on regional integration in Africa and offers some personal views of the author to evaluate the past, present and future of the AfCFTA.

Findings
The paper shows that the AfCFTA can support its State Parties’ industrialization and diversification, better integrate micro-, small- and medium-sized enterprises (MSMEs) to regional value chains, create jobs, encourage sustainable investments and help its State Parties have common positions on global issues and achieve development. But, it also shows the challenges facing the AfCFTA, which include infrastructure gap, revenue and job losses, overlapping membership of State Parties in Regional Economic Communities, cumbersome customs systems, difficulty to cross African borders, fledgling MSMEs and inadequate technical capacity on trade policy. Accordingly, it recommends that State Parties continuously take various actions to address these challenges and maximize the multiple benefits of the AfCFTA.

Originality/value
The paper provides a comprehensive and up-to-date appraisal of the opportunities and challenges of the AfCFTA, both in the context of the history of regional integration in Africa and the recent global shocks that adversely impacted the continent (COVID-19 and the war in Ukraine).
Key aspects of sustainability reporting quality and the future of GRI
Authors: Luque-Vílchez Mercedes , Cordazzo Michela , Rimmel Gunnar , Tilt Carol A. 
Published: May 2023

Purpose
This paper aims to investigate the current state of knowledge in key reporting aspects in relation to sustainability reporting in general and to reflect on their relevance to Global Reporting Initiative (GRI) in particular. In doing so, the major gaps in that knowledge are identified, and the paper proceeds to suggest further research avenues.

Design/methodology/approach
The authors conduct a review of papers published in leading journals concerning sustainability reporting to analyse the progress in the literature regarding three important reporting topics: materiality, comparability and assurance.

Findings
The review conducted in this study shows that there is still work to be done to ensure high-quality and consistent sustainability reporting. Key takeaways from the review of the extant literature are as follows: there is ongoing debate about the nature of sustainability reporting materiality, and single versus double materiality. Clearer guidance and better contextualisation are seen as essential for comparability, and, as GRI suggests, there is an important link to materiality that needs to be considered. Finally, assurance has not been mandatory under the GRI, but the current development at EU level might lead to the GRI principles being incorporated in the primary assurance standards.

Practical implications
In this paper, the authors review and synthesise the previous literature on GRI reporting dealing with three key reporting aspects.

Social implications
The authors extract some takeaways from the literature on materiality, comparability and assurance that will all be key challenges for GRI in the future.

Originality/value
This paper provides an updated review of the literature on GRI reporting dealing with three key reporting aspects.
How do ecotourists co-create value on digital platforms? The moderating role of ecotourist typology
Authors: Hernández-López Laura , Del Barrio-García Salvador , Prados-Peña Maria Belen 
Published: May 2023

Purpose
This study aims to examine the process of value co-creation (VCC) on digital ecotourism platforms and the role of perceived platform usefulness and user participation behavior in that process. The study also seeks to determine the extent to which the typology of the ecotourist moderates VCC.

Design/methodology/approach
A total of 420 users of a digital ecotourism platform participated in a study analyzing the factors that influence VCC. A mediation, moderation and conditional process analysis was used to test the proposed hypotheses. A K-means cluster analysis was also used to classify the ecotourists into four groups.

Findings
The results show that perceived platform usefulness has a strong influence on the generation of VCC and also on user participation behavior. In turn, user participation behavior is an important driver of VCC. This study also highlights the moderating role of the ecotourist typology in the formation of VCC on these digital platforms.

Practical implications
This study offers managers of digital ecotourism platforms a means to identify and motivate those ecotourists with the necessary skills and characteristics to become true co-creators of value.

Originality/value
This study contributes to the existing knowledge on how value is co-created on digital ecotourism platforms, confirming the important antecedent role of perceived platform usefulness and user participation behavior, as well as the moderating role of ecotourist typology.
Limit equilibrium slope stability analysis of column-supported embankment on weak ground
Authors: R.S.V. Rashma , B.R. Jayalekshmi , R. Shivashankar 
Published: May 2023

Purpose
The study aims to analyse the stability of embankments over the improved ground with stone column (SC) and pervious concrete column (PCC) inclusions using limit equilibrium method. The short-term stability of PCC-supported embankment system is rarely addressed. Therefore, the factor of safety (FOS) of column-supported embankment system is calculated using individual column and equivalent area models.

Design/methodology/approach
The stability analysis of column-supported embankment system is conducted using PLAXIS LE 2D. The various geometrical and shear strength parameters influencing the FOS of these embankment systems such as diameter of columns, spacing between columns, embankment height, friction angle of column material, undrained cohesion of weak ground and cohesion of PCC are considered.

Findings
The critical failure envelope of PCC-supported embankment system is observed to be of toe failure, whereas the failure envelope of stone column-supported embankment system is generally of deep-seated nature.

Originality/value
It is found that for PCC embankment system, FOS and failure envelope are not influenced by the geometrical/shear strength parameters other than height of embankment. However, for stone column-supported embankment system, FOS and failure envelope are dependent on all the shear strength and geometrical parameters considered in this study.
Effects of an abdominal binder on the development of incisional hernia in the long term: A prospective cohort study
Authors: Arici Parlak Emine , Iyigun Emine , Tastan Sevinc , Can Mehmet Fatih 
Published: May 2023

AbstractObjectivesThe effects of using an abdominal binder after abdominal surgery on the development of incisional hernias in the long term are far from certain. This study aims to analyse the effects of abdominal binder use on the development of incisional hernia in the long term.MethodsThe population of this prospective cohort study included 84 patients, who underwent abdominal surgery and were evaluated for the effects of abdominal binder use between September 2013 and April 2014. The study sample comprised 57 patients (30 used an abdominal binder and 27 did not use one), who took part in the first research and agreed to participate. We conducted a telephone survey with the participants in September 2017 and asked them to answer the questions on the symptoms of and the risk factors associated with incisional hernia.ResultsComparison of the two groups in terms of patient, surgical and treatment characteristics revealed no statistically significant difference (P > .05). Incisional hernia occurred in eight patients who used an abdominal binder and in five patients who did not use one. There was no statistically significant relationship between abdominal binder use and the development of incisional hernia 3 years after the abdominal surgery (P > .05).ConclusionsThis study found that abdominal binder use after abdominal surgery had no effects on the development of incisional hernia in the long term. Data on abdominal binder use were self‐reported by the patients. Better designed cohort studies on larger populations may be conducted in the future.
Effects of different drying methods on the properties, stability, and controlled release of Cornus officinalis flavonoids microparticles
Authors: Zhao Mengyue , Li Linlin , Cao Weiwei , Wang Zhe , Chu Qianqian , Bhandari Bhesh , Ren Guangyue , Duan Xu 
Published: May 2023

AbstractTo improve the stability and solubility of Cornus officinalis flavonoid (COF), spray drying (SD), freeze‐drying (FD), and microwave freeze drying (MFD) were used to encapsulate COF using whey isolate protein (WPI) and gum arabic as wall materials. The characterization of COF microparticles was performed with encapsulation efficiency (EE), particle size, morphology, antioxidant activity, structure, thermal stability, color, stability during storage, and in vitro solubility. The results showed that COF was successfully encapsulated in the wall material with an EE between 78.86% and 91.11%. The freeze‐dried microparticles had the highest EE (91.11%) and the lowest particle size (12.42 ± 16.73 µm). However, the particle size of COF microparticles of SD and MFD was relatively large. The 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) scavenging capacity of the microparticles obtained from SD (89.36 mg Vc/g) was higher than that of MFD (85.67 mg Vc/g), but the drying time and energy consumption of microparticles dried by SD and MFD were lower than those of FD. Furthermore, the spray‐dried COF microparticles had higher stability compared to FD and MFD when stored at 4°C for 30 days. In addition, the dissolution of COF microparticles prepared by SD and MFD was 55.64% and 57.35%, respectively, in simulated intestinal fluids, which was lower than that of FD (64.47%). Therefore, the application of microencapsulation technology showed significant advantages in improving the stability and solubility of COF, and the SD can be used for the preparation of microparticles considering energy cost and quality.Practical ApplicationCOF is an important bioactive ingredient, but its poor stability and water solubility decreases its pharmacological value. COF microparticles can improve the stability of COF, enhance the slow‐release effect, and expand its application in the food field. The drying method will affect the properties of COF microparticles. Thus, the structures and properties analysis of COF microparticles by different drying methods can provide a reference basis for the preparation and application of COF microparticles.
Abnormal activation of NF‐κB and MAPK signaling pathways affect osimertinib resistance and influence the recruitment of myeloid‐derived suppressor cells to shape the immunosuppressive tumor immune microenvironment
Authors: Wang Chao , Fei Kailun , Liu Lihui , Duan Jianchun , Wang Zhijie , Li Sini , Xu Jiachen , Zhang Xue , Tian Yanhua , Qu Yan , Bai Hua , Wang Jie 
Published: May 2023

AbstractBackgroundOsimertinib is the first‐line treatment for patients with epidermal growth factor receptor (EGFR) mutations, but the treatment options after drug resistance are limited. Previous studies have suggested that EGFR is in an immunosuppressive tumor immune microenvironment (TIME). However, the evolution of TIME after osimertinib resistance and whether this resistance can be overcome by targeting TIME needs to be further investigated.MethodsThe remodeling process and mechanism of TIME during the treatment with osimertinib were studied.ResultsThe proportion of EGFRL858R+T790M mutant tumor immune infiltrating cells was extremely low. Osimertinib treatment transiently triggered inflammatory cells, but several immunosuppressive cells infiltrated after drug resistance and formed a myeloid‐derived suppressor cell (MDSC)‐enriched TIME. The programmed cell death protein‐1 monoclonal antibody was not able to reverse the MDSC‐enriched TIME. Further analysis revealed that the activation of nuclear factor‐kappa B (NF‐κB) and mitogen‐activated protein kinase (MAPK) pathways recruited a large number of MDSCs via cytokines. Finally, MDSC secreted high levels of interleukin‐10 and arginase‐1 and created an immunosuppressive TIME.ConclusionsThus, our findings lay the foundation for the evolution of TIME in osimertinib treatment, establish the mechanism of immunosuppressive TIME after osimertinib resistance, and propose potential solutions.