bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of a large cohort of pancreatic cancer transcriptomic profiles to reveal the strongest prognostic factors
Authors: Posta Máté , Győrffy Balázs 
Published: June 2023

AbstractPancreatic adenocarcinoma remains a leading cause of cancer‐related deaths. In order to develop appropriate therapeutic and prognostic tools, a comprehensive mapping of the tumor's molecular abnormalities is essential. Here, our aim was to integrate available transcriptomic data to uncover genes whose elevated expression is simultaneously linked to cancer pathogenesis and inferior survival. A comprehensive search was performed in GEO to identify clinical studies with transcriptome‐level gene expression data of pancreatic carcinoma with overall survival data and normal pancreatic tissues. After quantile normalization, the entire database was used to identify genes with altered expression. Cox proportional hazard regression was employed to uncover genes most strongly correlated with survival with a Bonferroni correctedp < 0.01. Perturbed biological processes and molecular pathways were identified to enable the understanding of underlying processes. A total of 16 available datasets were combined. The aggregated database comprised data of 1640 samples for 20,443 genes. When comparing with normal pancreatic tissues, a total of 2612 upregulated and 1977 downregulated genes were uncovered in pancreatic carcinoma. Among these, we found 24 genes with higher expression which significantly correlated with overall survival length also. The most significant genes were ANXA8, FAM83A, KRT6A, MET, MUC16, NT5E, and SLC2A1. These genes remained significant after a multivariate analysis also including grade and stage. Here, we assembled a large‐scale database of pancreatic carcinoma samples and used this cohort to identify carcinoma‐specific genes linked to altered survival outcomes. As our analysis focused on genes with higher expression, these could serve as future therapy targets.
Characterization by X‐ray μCT of the air‐filled porosity of an agricultural soil at different matric potentials
Authors: Smet Sarah , Plougonven Erwan , Léonard Angélique , Degré Aurore 
Published: June 2023

AbstractTo describe various important soil processes like the release of greenhouse gases or the proliferation of microorganisms, it is necessary to assess quantitatively how the geometry and in particular the connectivity of the air‐filled pore space of a soil evolves as it is progressively dried. The availability of X‐ray computed microtomography (μCT) images of soil samples now allows this information to be obtained directly, without having to rely on the interpretation of macroscopic measurements using capillary theory, as used to be the case. In this general context, we present different methods to describe quantitatively the configuration of the air‐filled pore space in 3D μCT images of 20 separate samples of a loamy soil equilibrated at different matric potentials. Even though measures using μCT on such multi‐scale materials strongly depend on image resolution, our results show that in general, soil samples most often behave as expected, for example, connectivity increases with higher negative matric potential, while tortuosity decreases. However, simple correlations could not be found between the evolution of quantitative descriptors of the pore space at the different matric potentials and routinely measured macroscopic soil parameters. A statistical analysis of all soil samples concurrently confirmed this lack of correspondence.
Perceptions of support trickle down: Effects on energetic resources via psychological empowerment
Authors: Rofcanin Yasin , Wang Siqi , Heras Mireia Las , Taser Didem , Bosch Maria Jose , Fındıklı Mine Afacan , Vallina Andres Salas 
Published: June 2023

AbstractSupervisor perceptions of support are key, as they can influence their subordinates' perceptions of support and well‐being. Using a weekly diary data set of subordinates and their supervisors in Chile, we tested a trickle‐down effect of perceived supervisor support across three hierarchical levels: upper managers, supervisors, and non‐managerial employees. Drawing on the conservation of resources (COR) and social exchange theories as well as crossover research, we find that our model is largely supported. The findings revealed that supervisors' perceived support from managers (PMS) relates to subordinates' perceptions of support from their own supervisors (PSS). In turn, subordinates' PSS is positively associated with their emotional resource possession and sleep quality. Beyond these relationships, subordinates' psychological empowerment mediates the positive relationships between subordinates' PSS and their emotional resources as well as sleep quality. These findings suggest that supervisors who feel supported reciprocate with the more supportive treatment of subordinates, which likely enhances psychological empowerment, in turn driving the accumulation of emotional and physical resources.
Divergent in situ expression of IL‐31 and IL‐31RA between bullous pemphigoid and pemphigus vulgaris
Authors: Ergun Ecem Zeliha , Aoki Rui , Horváth Orsolya N. , Hartmann Daniela , Satoh Takashi K. , Calabrese Laura , Aksu Ayşe Esra Koku , Gürel Mehmet Salih , Manav Vildan , Flaig Michael J. , Sárdy Miklós , Ruzicka Thomas , French Lars E. , Bağcı Işın Sinem 
Published: June 2023

AbstractBullous pemphigoid (BP) and pemphigus vulgaris (PV) are two major autoimmune blistering skin diseases. Unlike PV, BP is accompanied by intense pruritus, suggesting possible involvement of the pruritogenic cytokine IL‐31. However, the underlying mechanisms of the clinical difference between BP and PV in terms of pruritus are not fully understood. To compare the expression levels of IL‐31 and its receptor IL‐31RA in the lesional skin, including peripheral nerves in BP and PV patients, immunohistochemical staining for IL‐31 and IL‐31RA was performed in skin samples of BP and PV patients and healthy controls (HC). The IL‐31RA‐expressing area in epidermis and peripheral nerves was analysed using ImageJ and the percentage of positive cells for IL‐31/IL‐31RA in dermal infiltrating cells was manually quantified. Quantitative analyses revealed that IL‐31/IL‐31RA expressions in the epidermis and dermal infiltrate were significantly increased in BP compared to PV and HC. The difference between BP and PV became more obvious when advanced bullous lesions were compared. Peripheral nerves in BP lesions presented significantly higher IL‐31RA expression compared to PV lesions. In conclusion, we found significantly augmented expressions of IL‐31/IL‐31RA in BP lesions, including peripheral nerves, in comparison to PV. These results suggest a possible contribution of IL‐31/IL‐31RA signalling to the difference between BP and PV in the facilitation of pruritus and local skin inflammation, raising the possibility of therapeutic targeting of the IL‐31/IL‐31RA pathway in BP patients.
Prospects for the future of pink salmon in three oceans: From the native Pacific to the novel Arctic and Atlantic
Authors: Lennox Robert J. , Berntsen Henrik H. , Garseth Åse Helen , Hinch Scott G. , Hindar Kjetil , Ugedal Ola , Utne Kjell R. , Vollset Knut Wiik , Whoriskey Frederick G. , Thorstad Eva B. 
Published: June 2023

AbstractWhile populations of other migratory salmonids suffer in the Anthropocene, pink salmon (Oncorhynchus gorbuscaSalmonidae) are thriving, and their distribution is expanding both within their natural range and in the Atlantic and Arctic following introduction of the species to the White Sea in the 1950s. Pink salmon are now rapidly spreading in Europe and even across the ocean to North America. Large numbers of pink salmon breed in Norwegian rivers and small numbers of individuals have been captured throughout the North Atlantic since 2017. Although little is known about the biology and ecology of the pink salmon in its novel distribution, the impacts of the species' introduction are potentially highly significant for native species and watershed productivity. Contrasts between pink salmon in the native and extended ranges will be key to navigating management strategies for Atlantic nations where the pink salmon is entrenching itself among the fish fauna, posing potential threats to native fish communities. One key conclusion of this paper is that the species' heritable traits are rapidly selected and drive local adaptation and evolution. Within the Atlantic region, this may facilitate further establishment and spread. The invasion of pink salmon in the Atlantic basin is ultimately a massive ecological experiment and one of the first examples of a major faunal change in the North Atlantic Ocean that is already undergoing rapid changes due to other anthropogenic stressors. New research is urgently needed to understand the role and potential future impacts of pink salmon in Atlantic ecosystems.
Evidence for density‐dependent effects on body composition of a large omnivore in a changing Greater Yellowstone Ecosystem
Authors: Corradini Andrea , Haroldson Mark A. , Cagnacci Francesca , Costello Cecily M. , Bjornlie Daniel D. , Thompson Daniel J. , Nicholson Jeremy M. , Gunther Kerry A. , Wilmot Katharine R. , van Manen Frank T. 
Published: June 2023

AbstractUnderstanding the density‐dependent processes that drive population demography in a changing world is critical in ecology, yet measuring performance–density relationships in long‐lived mammalian species demands long‐term data, limiting scientists' ability to observe such mechanisms. We tested performance–density relationships for an opportunistic omnivore, grizzly bears (Ursus arctos, Linnaeus, 1758) in the Greater Yellowstone Ecosystem, with estimates of body composition (lean body mass and percent body fat) serving as indicators of individual performance over two decades (2000–2020) during which time pronounced environmental changes have occurred. Several high‐calorie foods for grizzly bears have mostly declined in recent decades (e.g., whitebark pine [Pinus albicaulis, Engelm, 1863]), while increasing human impacts from recreation, development, and long‐term shifts in temperatures and precipitation are altering the ecosystem. We hypothesized that individual lean body mass declines as population density increases (H1), and that this effect would be more pronounced among growing individuals (H2). We also hypothesized that omnivory helps grizzly bears buffer energy intake from changing foods, with body fat levels being independent from population density and environmental changes (H3). Our analyses showed that individual lean body mass was negatively related to population density, particularly among growing‐age females, supporting H1 and partially H2. In contrast, population density or sex had little effect on body fat levels and rate of accumulation, indicating that sufficient food resources were available on the landscape to accommodate successful use of shifting food sources, supporting H3. Our results offer important insights into ecological feedback mechanisms driving individual performances within a population undergoing demographic and ecosystem‐level changes. However, synergistic effects of continued climate change and increased human impacts could lead to more extreme changes in food availability and affect observed population resilience mechanisms. Our findings underscore the importance of long‐term studies in protected areas when investigating complex ecological relationships in an increasingly anthropogenic world.
The benefits, challenges, and best practice for patient and public involvement in evidence synthesis: A systematic review and thematic synthesis
Authors: Agyei‐Manu Eldad , Atkins Nadege , Lee Bohee , Rostron Jasmin , Dozier Marshall , Smith Maureen , McQuillan Ruth 
Published: June 2023

AbstractIntroductionDespite the growing evidence on patient and public involvement (PPI) in health research, little emphasis has been placed on understanding its quality and appropriateness to evidence synthesis (ES) and systematic reviews (SR). This study aimed to synthesise qualitative evidence on the benefits, challenges, and best practices for PPI in ES/SR projects from the perspectives of patients/public and researchers.MethodsWe searched Ovid MEDLINE, Ovid EMBASE, Cochrane Library and CINAHL Plus. We also searched relevant grey literature and conducted hand‐searching to identify qualitative studies which report the benefits and challenges of PPI in individual ES/SR projects. Studies were independently screened by two reviewers for inclusion and appraised using the Joanna Briggs Institute's Qualitative Tool. Included studies were synthesised narratively using thematic synthesis.ResultsThe literature search retrieved 9923 articles, of which eight studies were included in this review. Five themes on benefits emerged: two from patients'/public's perspective—gaining knowledge, and empowerment; and three from researchers' perspective—enhancing relevance, improving quality, and enhancing dissemination of findings. Six themes on challenges were identified: three from patients'/public's perspective—poor communication, time and low self‐esteem; and three from researchers' perspective—balancing inputs and managing relations, time, and resources and training. Concerning recommendations for best practice, four themes emerged: provision of sufficient time and resources, developing a clear recruitment plan, provision of sufficient training and support, and the need to foster positive working relationships.ConclusionHighlighting the benefits and challenges of PPI in ES/SR projects from different stakeholder perspectives is essential to understand the process and contextual factors and facilitate meaningful PPI in ES/SR projects. Future research should focus on the utilisation of existing frameworks (e.g., Authors and Consumers Together Impacting on eVidencE [ACTIVE] framework) by researchers to help describe and/or report the best approaches and methods for involving patients/public in ES/SRs projects.Patient and Public ContributionThis review received great contributions from a recognised PPI partner, the Chair of the Cochrane Consumer Network Executive, to inform the final stage of the review (i.e., interpretation, publication and dissemination of findings). The PPI partner has been included as an author of this review.
Levels and influencing factors of mental workload among intensive care unit nurses: A systematic review and meta‐analysis
Authors: Teng Mei , Yuan Zhongqing , He Hong , Wang Jialin 
Published: June 2023

AbstractAimThe purpose of this systematic review was to determine the levels and influencing factors of mental workload in intensive care unit nurses.BackgroundIntensive care unit nurses have a high mental workload level. To our knowledge, no meta‐analytic research investigating the levels of mental workload in intensive care unit nurses and related factors has yet been performed.DesignThis article is a systematic review and meta‐analysis.MethodsEleven electronic databases were searched from the database setup dates until 31 December 2022. The research team independently conducted study selection, quality assessments, data extractions and analysis of all included studies. The PRISMA guideline was used to guide reportage of the systematic review and meta‐analysis.ResultsSeventeen studies were included. In these studies, the pooled mean score of mental workload was 68.07 (95%CI:64.39–71.75). Furthermore, subgroup analyses indicated that intensive care unit nurses' mental workload differed significantly by countries, sample size and publication year. The mental workload influential factors considered were demographic, work‐related and psychological factors.ConclusionHospital administrators should develop interventions to reduce mental workload to enhance the mental health of intensive care unit nurses and nursing care quality. Hospital managers should pay attention to the mental health of nurses and guide them to correctly relieve occupational stress and reduce mental workload.
Fabrication and characterizations of Eu2+‐Dy3+ co‐doped SrAl2O4 ceramics with persistent luminescence
Authors: Li Tingsong , Liu Qiang , Zhu Danyang , Chen Penghui , Jing Yanqiu , Wu Junlin , Chen Haohong , Hreniak Dariusz , Nikl Martin , Li Jiang 
Published: June 2023

Abstract(Sr0.97Eu0.01Dy0.02)Al2O4 persistent luminescence (PersL) ceramics were fabricated by solid‐state reactive sintering in vacuum combined with hot isostatic pressing (HIP) using H3BO3 as a sintering additive. The phase composition, microstructure, luminescence properties, trap state, and PersL performance of HIP post‐treated (Sr0.97Eu0.01Dy0.02)Al2O4 PersL ceramics were discussed. For the (Sr0.97Eu0.01Dy0.02)Al2O4 PersL ceramics after HIP post‐treatment, the initial luminescence intensity of the ceramics reached over 6400 mcd/m2 with simulated daylight irradiation of 1000 lx for 5 min, and the persistent emission decay time > 17 h. This is much better than the SrAl2O4:Eu2+,Dy3+ PersL powders and the other luminescent ceramics. In addition, this method is a solid‐state reactive sintering method for synthesizing ceramics, which has the advantages of low cost and simple operation, and is suitable for large‐scale, high‐volume industrial production.
Anti‐fibrotic effect of ciglitazone in HRV‐induced airway remodelling cell model
Authors: Wieczfinska Joanna , Pawliczak Rafal 
Published: June 2023

AbstractFibrosis is an important phenomenon as it can occur early in the pathogenesis of asthma; it may be associated with disease severity and resistance to therapy. There is a strong evidence that infection caused by human rhinovirus (HRV) contributes to remodelling process, but there is lack of studies clearly explaining this pathway. Synthetic peroxisome proliferator‐activated receptor (PPAR) γ presents immunomodulatory and anti‐inflammatory features. In this study, we examined immunomodulatory properties of ciglitazone – PPAR‐γ agonist, in development and modulation of airway remodelling. Epithelial cells (NHBE) and two lines of fibroblasts (WI‐38, HFL1) were stimulated with ciglitazone and rhinovirus. The expression of genes related to airway remodelling process were analysed in the cells; moreover NF‐κB, c‐Myc and STAT3 were silenced in order to estimate potential pathways involved. Ciglitazone decreased mRNA expression of MMP‐9 and TGF‐β. It also modified the expression of α‐SMA and collagen after rhinovirus infection. Transcription factors knockdown altered the levels of expression. The results suggest possible anti‐fibrotic activity of PPAR‐γ agonist in human airway cells. Ciglitazone has been shown to be dependent on NF‐κB‐ and STAT3‐related pathways, thus, the PPAR‐γ agonist may have therapeutic potential for the treatment of airway remodelling in asthma.
Patterns of maladaptive exercise behavior from ages 14–24 in a longitudinal cohort
Authors: Schaumberg Katherine , Bulik Cynthia M. , Micali Nadia 
Published: June 2023

BackgroundExercise for weight loss and maladaptive exercise (exercise that results in negative consequences or interference with daily life) are common behaviors among youth and are associated with increased risk of disordered eating symptoms. The current study clarifies processes that influence exercise‐related risk in adolescence and young adulthood, including the frequency with which young people transition between engaging in exercise for weight loss and experiencing negative consequences of this behavior.MethodParticipants from the Avon Longitudinal Study of Parents and Children (ALSPAC) reported on eating disorder cognitions at age 14, and exercise behavior at ages 14, 16, 18, and 24 years old. Analyses examined rates of transition between the categories of ‘No Exercise for Weight Loss’, ‘Exercise for Weight Loss’, and ‘Maladaptive Exercise’ over time, identified overall trends in endorsement of exercise for weight loss and maladaptive exercise, and clarified predictors of these behaviors.ResultsEndorsement of exercise for weight loss and maladaptive exercise increased over time in both males and females. Those in the ‘Exercise for Weight Loss’ category were more likely than those in the ‘No Exercise for Weight Loss Category’ to transition to ‘Maladaptive Exercise’ over time. Body mass index (Age 13) and fear of weight gain (Age 14) were consistent predictors of maladaptive exercise across sex.ConclusionsResults support re‐framing motivations for exercise in youth away from weight loss at a population level and targeting reductions in fear of weight gain for high‐risk individuals.
Characterizing IT asset disposition flows for the circular economy: A case study on export for reuse from Ireland
Authors: McMahon Kathleen , Uchendu Chidinma , Fitzpatrick Colin 
Published: June 2023

AbstractUnderstanding flows of resource‐rich electrical and electronic equipment throughout its life cycle is increasingly important in the development of global circular economies, reflected by heavy legislative focuses on waste prevention and resource use efficiency. This research facilitates broader material flow analysis by characterizing flows of professional IT equipment within the Republic of Ireland, emphasizing the flow of legal exports for the purposes of refurbishment and reuse. The analysis of transboundary movement of non‐waste used equipment contributes to a less often measured, but influential, facet of material flows. Eight key exporters of used equipment, comprising original equipment manufacturers, information technology asset disposition companies, and waste treatment facilities, were interviewed to characterize the sector, map the flow of materials, and identify gaps in existing reporting. Interviewed organizations declared exports of used equipment by category using a voluntary declaration form. Two key flows were identified representing currently unreported and unmeasured flows of non‐waste professional equipment. A total of 441,261 units of equipment were declared to be exported for reuse from the Republic of Ireland through these previously unmeasured flows in 2019. Product keys developed by United Nations University were used to estimate the weight of total units exported as approximately 576 metric tons, amounting to an additional approximately 9% of the weight of IT equipment collected in the Republic of Ireland in 2018, or 0.1 kg per inhabitant. These quantifications of IT equipment exported for reuse will be a key component of future material flow analyses in the development of a circular economy.