bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between negatively perceived parenting attitudes and dissociation: a cross-sectional study on the general population in Japan
Authors: Wang Baihui , Kuroki Toshihide 
Published: August 2023

ObjectivesMany studies have reported that early traumatic experiences, mainly abuse, are associated with forming dangerous attachments and a contributing factor to dissociation. On the other hand, other studies have investigated the association of non-abusive nurturing and attachment styles with dissociation. The aim of this study is to determine the frequency of dissociative experiences in the general Japanese population and investigate the effects of “overprotection” and “lack of care” as nurturing styles and “abandonment anxiety” and “avoidance of intimacy” as attachment styles on dissociation.MethodsA total of 1,042 residents aged 18 to 69 years were administered with the Dissociative Experiences Scale (DES), the Japanese version of the WHO-5 Well-Being Index (WHO-5-J), the Parental Bonding Instrument (PBI), and the Experiences in Close Relationships Inventory-the-generalized-other-version (ECR-GO). Hierarchical multiple regression analyses on the effects of “overprotection” and “care” as nurturing attitudes “abandonment anxiety” and “avoidance of intimacy” as attachment styles on dissociation (DES-NDI and DES-T) were conducted.ResultsBased on the findings of this study, “care” and “overprotection” as nurturing attitudes were shown to be a contributing factor to dissociation (DES-NDI and DES-T). “Avoidance of intimacy” as an attachment style was shown to contribute to pathological dissociation. On the other hand, the influence of attachment style on the relationship between nurturing style and dissociation was not determined.DiscussionThis study provided essential data on the distribution of dissociative experiences in the general Japanese population. It was indicated that nurturing style, particularly overprotection, may be linked to nonfunctional stress coping and interpersonal anxiety and could be a contributing factor to mental disorders, including dissociation. Furthermore, considering that the effect of nurturing styles on dissociation does not vary with attachment styles, the effect of nurturing styles on dissociation may be more profound.
A systematic review of mental health in rural Andean populations in Latin America during the COVID-19 pandemic
Authors: Moya-Salazar Jeel , Jaime-Quispe Alexis , Cañari Betsy , Moya-Espinoza Jeel G. , Contreras-Pulache Hans 
Published: August 2023

BackgroundCOVID-19 has been causing mental health problems around the world, with rural and indigenous peoples likely to be the most affected. This systematic review synthesizes and critically analyzes the existing literature on mental disorders in the rural Andean population in Latin America.MethodsA systematic review with narrative synthesis was carried out following the PRISMA guidelines. We searched nine databases (PubMed/MEDLINE, Scopus, EMBASE, ScienceDirect, Web of Science, Cochrane, Scielo, LILACS, and Latindex), five public prepublication servers (SocArXiv, medRxiv, bioRxiv, SportRXiv, and Preprints), ALICIA, and Google Scholar for articles that included the analysis of mental health problems using data collected from the rural Andean population in Latin America. These were eligible for inclusion. Articles that included Non-Latin American populations (including European or African migrants) and studies conducted prior to the COVID-19 pandemic (since the declaration of national lockdown) were excluded.ResultsA total of 23,761 articles were retrieved, 14 of which met the inclusion requirements. Most were cross-sectional (n = 12) and related to anxiety (n = 9), depression (n = 8), and stress (n = 5). The mental health analysis of 5,976 rural dwellers from four countries in Latin America also included gray literature studies (n = 7) that allowed the quantification of mental health problems in adults (n = 7) and adolescents/children (n = 4). Only one study was multinational, and the quality of publications varied. Despite the high frequency of anxiety, depression, and stress symptoms among rural Latin American populations during COVID-19, published research is very limited. This review found preliminary evidence that the frequency of anxiety (45%), depression (27.6%), and stress (33.1%) in the rural population was associated with pandemic restrictions across countries. Measures of other psychiatric problems, such as distress or suicidal ideation, cannot be estimated.ConclusionRegional-wide studies investigating changes in the frequency of symptoms of mental health problems in the context of the COVID-19 pandemic are warranted to inform culturally adapted prevention strategies. This study is limited to a narrative synthesis and may be subject to publication bias.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=320489.
Revealing the impact of built environment, air pollution and housing price on health inequality: an empirical analysis of Nanjing, China
Authors: Ding Yu , Wang Chenglong , Wang Jiaming , Wang Peng , Huang Lei 
Published: August 2023

IntroductionResidential segregation have become a common phenomenon in China recently. Socioeconomically disadvantaged residents were more likely to live in communities with higher PM2.5 concentrations and poorer built environment, which may ultimately lead to a higher health risk, further exacerbating health inequalities. However, the reasons for health inequalities under residential segregation remain unclear.MethodsThis study quantified the built environment, air pollution, mortality rate and housing price at 1 km × 1 km grid scale. Moderating effect model, mediating effect model, moderated mediating effect model were used to progressively clarify the relationship between the four.ResultsResults show that, in terms of spatial distribution, the central area has high housing price with good built environment, low PM2.5 concentration and low mortality rate. While the suburban area has low housing price, poor built environment, high PM2.5 concentration and high mortality rate. Additionally, built environment can not only reduce health risks through moderating effect, but also affect health through the mediating effect of PM2.5. There is heterogeneity in moderating effect of built environment in different locations. Housing prices can moderate the effect of built environment on health. This study would offer important reference for urban planning to mitigate the effect of built environment inequalities on health inequalities in China.
The Long COVID experience from a patient's perspective: a clustering analysis of 27,216 Reddit posts
Authors: Ayadi Hanin , Bour Charline , Fischer Aurélie , Ghoniem Mohammad , Fagherazzi Guy 
Published: August 2023

ObjectiveThis work aims to study the profiles of Long COVID from the perspective of the patients spontaneously sharing their experiences and symptoms on Reddit.MethodsWe collected 27,216 posts shared between July 2020 and July 2022 on Long COVID-related Reddit forums. Natural language processing, clustering techniques and a Long COVID symptoms lexicon were used to extract the different symptoms and categories of symptoms and to study the co-occurrences and correlation between them.ResultsMore than 78% of the posts mentioned at least one Long COVID symptom. Fatigue (29.4%), pain (22%), clouded consciousness (19.1%), anxiety (17.7%) and headaches (15.6%) were the most prevalent symptoms. They also highly co-occurred with a variety of other symptoms (e.g., fever, sinonasal congestion). Different categories of symptoms were found: general (45.5%), neurological/ocular (42.9%), mental health/psychological/behavioral (35.2%), body pain/mobility (35.1%) and cardiorespiratory (31.2%). Posts focusing on other concerns of the community such as vaccine, recovery and relapse and, symptom triggers were detected.ConclusionsWe demonstrated the benefits of leveraging large volumes of data from Reddit to characterize the heterogeneity of Long COVID profiles. General symptoms, particularly fatigue, have been reported to be the most prevalent and frequently co-occurred with other symptoms. Other concerns, such as vaccination and relapse following recovery, were also addressed by the Long COVID community.
Sense of Coherence or resilience as predictors of psychological distress in nursing students during the COVID-19 pandemic
Authors: Hasimi Leila , Ahmadi Mehrnaz , Hovyzian Shahla Assadi , Ahmadi Ali 
Published: August 2023

BackgroundThe COVID-19 pandemic lead to the occurrence of numerous psychological distress among students. This study aimed to determine the level of psychological distress as well as the predictive role of Sense of Coherence (SOC) and resilience in nursing students.MethodsA cross-sectional descriptive study was conducted on 310 nursing students in Ahvaz Jundishapur University of Medical Sciences, Iran. The data of the study was collected through the demographic information questionnaire, the General Health Questionnaire (GHQ), the Academic Resilience Inventory (ARI), and the Sense of Coherence Scale (SOC-13).ResultsStudents' mean scores for the GHQ, ARI, and SOC were 5.81 ± 1.37, 102.88 ± 11.91, and 54.54 ± 6.46, respectively. Regression models showed that two domains of SOC [meaningfulness (β = −0.28, p &lt; 0.001), manageability (β = −0.19, p = 0.001)], female gender (β = 0.12, p = 0.015), and overall ARI (β = −0.12, p = 0.037), were significantly associated with the GH of nursing students. SOC domains [meaningfulness (β = −0.19, p = 0.002), manageability (β = −0.15, p = 0.006)], problem-oriented/positive thinking domain of ARI (β = −0.15, p = 0.011), sex (β = 0.12, p = 0.015), and history of death in first-degree relatives (β = 0.12, p = 0.021) were significantly associated with social dysfunction domain of GH. Three domains of SOC [meaningfulness (β = −0.26, p &lt; 0.001), manageability (β = −0.13, p = 0.032), and comprehensibility (β = −0.13, p = 0.039)], were significantly associated with psychological distress domain of GH.ConclusionOur results indicated that low SOC and resilience were predictors of psychological distress in nursing students. Accordingly, interventions such as teaching stress management skills, the skills of using positive coping methods in dealing with stressful situations, and self-management skills are necessary to improve the level of resilience and SOC in nursing students.
Cryptosporidium parvum-induced neutrophil extracellular traps in neonatal calves is a stage-independent process
Authors: Grabbe Magdalena , Conejeros Iván , Velásquez Zahady D. , Hasheminasab Seyed Sajjad , Kamena Faustin , Wehrend Axel , Gärtner Ulrich , Taubert Anja , Hermosilla Carlos Rodrigo 
Published: August 2023

IntroductionInfections with the apicomplexan obligate intracellular parasite Cryptosporidium parvum lead to cryptosporidiosis—a worldwide zoonotic infection. C. parvum is one of the most common diarrheal pathogens in young calves, which are the main reservoir of the pathogen. Cryptosporidiosis leads to severe economic losses in the calf industry and being a major contributor to diarrhea morbidity and mortality in children. Polymorphonuclear neutrophils (PMN) are part of the innate immune system. Their effector mechanisms directed against invasive parasites include phagocytosis, production of antimicrobial molecules as well as the formation of so-called neutrophil extracellular traps (NETs). Like other leukocytes of the innate immune system, PMN are thus able to release chromatin fibers enriched with antimicrobial granular molecules extracellularly thereby immobilizing and partially killing invasive bacteria, viruses, fungi and parasites.MethodsIn vitro interactions of neonatal bovine PMN and C. parvum-oocysts and sporozoites were illustrated microscopically via scanning electron microscopy- and live cell imaging 3D holotomographic microscopy analyses. C. parvum-triggered NETosis was quantified via extracellular DNA measurements as well as verified via detection of NET-typical molecules [histones, neutrophil elastase (NE)] through immunofluorescence microscopy analysis. To verify the role of ATP in neonatal-derived NETosis, inhibition experiments were performed with NF449 (purinergic receptor antagonist with high specificity to P2X1 receptor).Results and discussionUsing immunofluorescence- and SEM-based analyses, we demonstrate here for the first time that neonate bovine PMN are capable of forming NETs against C. parvum-sporozoites and oocysts, thus as a stage-independent cell death process. Our data further showed that C. parvum strongly induces suicidal neonatal NETosis in a P2X1-dependent manner, suggesting anti-cryptosporidial effects not only through firm sporozoite ensnarement and hampered sporozoite excystation, but also via direct exposure to NETs-associated toxic components.
Challenges for Developing Palliative Care Services in Resource- Limited Settings of Kazakhstan
Authors: Salikhanov Islam , Connor Stephen R. , Kunirova Gulnara , Khashagulgova Fatima , Nazarova Gulzhaina , Crape Byron Lawrence , Katapodi Maria C. 
Published: August 2023

Background: Approximately 40 million people in need of palliative care worldwide, while 80% of them live in low- and middle-income countries. Kazakhstan, a low-to middle-income country with a reforming healthcare system, is committed to improving quality and accessibility of care for its 100,000 terminal patients in need of palliative care.Policy Options and Recommendations: To join the group of countries where palliative care is available, accessible, and affordable, Kazakhstan must integrate palliative services into the mainstream healthcare system at all levels, from primary healthcare to hospices, and from major cities to remote villages. Based on the evidence thoroughly collected directly from the Ministry of Health, authors propose a feasible set of recommendations regarding palliative policy, pain relief, infrastructure, workforce, and education, which could be implemented in LMICs beyond Kazakhstan.Conclusion: This study presents an analysis of challenges, recent developments, and needs of palliative care in Kazakhstan, including funding, policy, workforce, education, and infrastructure, providing an evidence base and recommendations for future development of palliative care in Kazakhstan and in other LMICs.
Thermodynamic and Economic Simulation of an Organic Rankine Cycle for the Utilization of Combustion Gas Produced in Small Landfills in Antioquia, Colombia
Authors: Rocha-Meneses Lisandra , Zea Jhojan , Martínez Brandon , Arrieta Carlos , Risco Mario Luna-del , Villegas Sebastián , Arredondo Carlos 
Published: August 2023

This study presents a simulation of an organic Rankine cycle (ORC) for the utilization of combustion gas produced in small landfills in Antioquia, Colombia, with a focus on the municipality of Angostura. This municipality has been chosen as the focus of this study due to its growing population and industrial and tourism development, bringing with them the need for sustainable waste and energy management solutions. The proposed ORC system includes two evaporators, two turbines, a condenser, a pump, and a generator, similar to successful systems reported in the literature. A sensitivity analysis was performed to investigate the impact of pressure, temperature, and mass flow on the system’s net power output and thermodynamic efficiency. The results showed that the system reached a net power output of 64.33 kW with an overall power plant efficiency of 13.03% and an investment cost of 192,340 USD based on a reference cost of 2990 USD/kW. The study also found that the system’s use in Angostura is economically feasible, with a net present value of 31,208 USD over a 10-year investment study. The sensitivity analysis revealed that temperature and pressure have direct effects on the system’s performance and economic viability. The municipality’s geomorphological characteristics were found to reduce the risk of groundwater contamination, while surface waters may still be vulnerable to contamination from leachates. Overall, this study highlights the feasibility and potential benefits of utilizing an ORC system, in which the combustion heat from methane gas produced in small landfills in Antioquia, Colombia, is harnessed for energy production.
Porphyromonas gingivalis Peptidyl Arginine Deiminase (PPAD) in the Context of the Feed-Forward Loop of Inflammation in Periodontitis
Authors: Prucsi Zsombor , Zimny Agnieszka , Płonczyńska Alicja , Zubrzycka Natalia , Potempa Jan , Sochalska Maja 
Published: August 2023

Periodontitis is a widespread chronic inflammatory disease caused by a changed dysbiotic oral microbiome. Although multiple species and risk factors are associated with periodontitis, Porphyromonas gingivalis has been identified as a keystone pathogen. The immune-modulatory function of P. gingivalis is well characterized, but the mechanism by which this bacterium secretes peptidyl arginine deiminase (PPAD), a protein/peptide citrullinating enzyme, thus contributing to the infinite feed-forward loop of inflammation, is not fully understood. To determine the functional role of citrullination in periodontitis, neutrophils were stimulated by P. gingivalis bearing wild-type PPAD and by a PPAD mutant strain lacking an active enzyme. Flow cytometry showed that PPAD contributed to prolonged neutrophil survival upon bacterial stimulation, accompanied by the secretion of aberrant IL-6 and TNF-α. To further assess the complex mechanism by which citrullination sustains a chronic inflammatory state, the ROS production and phagocytic activity of neutrophils were evaluated. Flow cytometry and colony formation assays showed that PPAD obstructs the resolution of inflammation by promoting neutrophil survival and the release of pro-inflammatory cytokines, while enhancing the resilience of the bacteria to phagocytosis.
Gut Microbiota and Respiratory Infections: Insights from Mendelian Randomization
Authors: Huang Shengyu , Li Jiaqi , Zhu Zhihao , Liu Xiaobin , Shen Tuo , Wang Yusong , Ma Qimin , Wang Xin , Yang Guangping , Guo Guanghua , Zhu Feng 
Published: August 2023

The role of the gut microbiota in modulating the risk of respiratory infections has garnered increasing attention. However, conventional clinical trials have faced challenges in establishing the precise relationship between the two. In this study, we conducted a Mendelian randomization analysis with single nucleotide polymorphisms employed as instrumental variables to assess the causal links between the gut microbiota and respiratory infections. Two categories of bacteria, family Lactobacillaceae and genus Family XIII AD3011, were causally associated with the occurrence of upper respiratory tract infections (URTIs). Four categories of gut microbiota existed that were causally associated with lower respiratory tract infections (LRTIs), with order Bacillales and genus Paraprevotella showing a positive association and genus Alistipes and genus Ruminococcaceae UCG009 showing a negative association. The metabolites and metabolic pathways only played a role in the development of LRTIs, with the metabolite deoxycholine acting negatively and menaquinol 8 biosynthesis acting positively. The identification of specific bacterial populations, metabolites, and pathways may provide new clues for mechanism research concerning therapeutic interventions for respiratory infections. Future research should focus on elucidating the potential mechanisms regulating the gut microbiota and developing effective strategies to reduce the incidence of respiratory infections. These findings have the potential to significantly improve global respiratory health.
Les Équidés
Authors: Guadelli Jean-Luc 
Published: August 2023

Most Equid remains in layers XXa to VII may be attributed to Equus caballus but it was not possible for us to improve our identification because the molars we studied present anatomical characteristics of würmian Horses when their dimensions are near those of the same teeth of ante-würmian Horses. Furthermore, the small size of our sample has limited the range of our conclusions.
Finally a deciduous lower tooth is attributed to Equus hydruntinus.
Digital Pathology for Analyzing Endomyocardial Biopsy Specimens
Authors: Slavinskiy A. A. , Verevkin A. A. , Chuprinenko L. M. , Drushevskaya V. L. , Kristesiashvili M. V. 
Published: August 2023

Introduction: Visual assessment of endomyocardial biopsy (EMB) specimens may result in errors due to the human factor and inability to obtain quantitative data on the intensity of immunohistochemical (IHC) reactions and severity of pathological changes in the heart transplant. Detailed digital characterization of EMB specimens based on automated or semi-automated computer-assisted morphometry improves the diagnostic accuracy of EMB. Objective: To develop a method of and algorithms for digital computer-assisted analysis of EMB specimens to quantify pathomorphological and immunophenotypic changes in the myocardium of patients with various types and grades of heart transplant rejection. Materials and methods: We studied 257 EMB specimens from 56 heart transplant recipients at Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1 (Krasnodar, Russian Federation). Sections were stained with hematoxylin and eosin. We used the streptavidin-biotin method to determine the CD68 expression and computer-assisted morphometry of digital images to measure the area of pathological changes and CD68 expression. Results: When developing a method for computer-assisted analysis of EMB specimens, we proposed a new evaluation criterion: staining area coefficient (%) that is a ratio of the total stained area to the total section area. We created and field-tested algorithms for digital morphometric analysis to assess the intensity of IHC reactions and to identify the relative area of pathological changes in the EBM specimens. Conclusions: New digital criteria for diagnosing heart transplant rejections are to improve the accuracy of EMB results interpretation, but can also be used for analyzing other biopsy specimens.