bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolutionary history of Euteliidae (Lepidoptera, Noctuoidea)
Authors: Zahiri Reza , Holloway Jeremy D. , Rota Jadranka , Schmidt B. Christian , Pellinen Markku J. , Kitching Ian J. , Miller Scott E. , Wahlberg Niklas 
Published: April 2023

AbstractWe performed a molecular phylogenetic analysis on the family Euteliidae to clarify deep divergences and elucidate evolutionary relationships at the level of the subfamily, tribe, and genus. Our dataset consists of 6.3 kbp of one mitochondrial and seven nuclear DNA loci and was analysed using model‐based phylogenetic methods, that is, maximum likelihood and Bayesian inference. Based on the recovered topology, we recognize two subfamilies, Euteliinae and Stictopterinae, and the tribes Stictopterini and Odontini. We identify apomorphic morphological character states for Euteliidae and its component subfamilies and tribes. Several genera (e.g., Targalla, Paectes, Marathyssa, Eutelia) were found polyphyletic and require taxonomic revision. Two new genera (Niklastelia Zahiri & Holloway gen.nov. and Pellinentelia Holloway & Zahiri gen.nov.) are described and a number of taxonomic changes (new combinations and new synonymies) are established. The Neotropical genus Thyriodes, currently included in Euteliidae, is found to be associated with Erebinae (Erebidae). The divergence time estimate for the split between the Euteliidae and Noctuidae is at 53 Ma, and the Euteliidae subfamilies Euteliinae and Stictopterinae are estimated to have diverged at 42 Ma. In Stictopterinae, the tribes Stictopterini and Odontodini split at 31 Ma, while Euteliinae began diversifying at 34 Ma. Malpighiales are inferred to have been the ancestral larval hostplant order for Euteliidae. The ancestors of Stictopterinae also appear to have been Malpighiales feeders, but then diverged to Malvales specialists (Odontodini) and Malpighiales specialists (Stictopterini) hostplants. Larvae of Stictopterini appear to be restricted primarily to Clusiaceae, apart from a few records from Dipterocarpaceae. In Euteliinae, Anacardiaceae are predominant as larval hosts. Thus, all hosts in the family are lactiferous, possibly providing some degree of pre‐adaptation for exploiting Dipterocarpaceae.
Design of a Sliding Mode-Adaptive Proportional-Integral-Derivative Control for Aerial Systems With a Suspended Load Exposed to Wind Gusts
Authors: Di Paola Vincenzo , Goldsztejn Alexandre , Zoppi Matteo , Caro Stéphane 
Published: April 2023

Abstract
Wind gusts are among the well-known disturbances that afflict aerial systems. A tracking task for a load suspended by massless rigid bars and quadrotors is considered in this paper. The complexity of the tracking task lies in the presence of wind gusts. Therefore, a self-tuning gain technique for a proportional-integral-derivative (PID) control is introduced to accomplish tracking tasks when wind gusts appear. To automatically tune the PID gains, a sliding mode condition is exploited. The stability of this approach, considering bounded disturbances, is guaranteed by introducing a supervisory control designed through the Lyapunov method. The proposed solution and its performances were tested through simulation and compared with both PD and PID controls.
The origin of platinum group minerals in oceanic crust
Authors: Evans Katy , Reddy Steven M. , Merle Renaud , Fougerouse Denis , Rickard William D.A. , Saxey David W. , Park Jung-Woo , Doucet Luc , Jourdan Fred 
Published: April 2023

Abstract
Highly siderophile elements (HSEs), including Re and Os, are used extensively as geochemical tracers and geochronometers to investigate the formation and evolution of Earth’s crust and mantle. Mantle rocks are commonly serpentinized, but the effect of serpentinization on the distribution of HSEs is controversial because HSEs are commonly hosted by rare, micrometer- to sub-micrometer-scale grains of platinum group minerals (PGMs) of ambiguous origin that are challenging to identify, characterize, and interpret. In this study, atom probe tomography (APT) is used to characterize two spatially close PGM grains hosted by a partially serpentinized harzburgite from Macquarie Island, Australia. The APT data reveal an extraordinary level of detail that provides insights into the origin of a complex Cu–Pt alloy grain (average composition ~Cu4Pt). The grain hosts Fe-, Ni-, and Pt-rich sub-grains associated with Rh, variably overlapping networks of Pd- and Cd-enrichment, and OH-rich volumes identified as fluid inclusions. Osmium and Ru are hosted by an idioblastic laurite (RuS2) grain. Compositional, textural, and phase-diagram constraints are consistent with a modified pre-serpentinization origin for the PGMs, and a comparison between observed and calculated grain distributions indicate that while Os isotope ratios were probably unaffected by serpentinization, whole-rock and grain-scale HSE and isotopic ratios may have been decoupled during serpentinization.
Papillary vitreous detachment as a possible accomplice in non-arteritic anterior ischaemic optic neuropathy
Authors: Li Dong , Sun Shuo , Liang Jingli , Yue Yi , Yang Jihong , Zhi Yuntao , Zhang Xiaomin , Yu Rongguo , Li Xiaorong 
Published: April 2023

AimTo evaluate the role of papillary vitreous detachment in the pathogenesis of non-arteritic anterior ischaemic optic neuropathy (NAION) by comparing the features of vitreopapillary interface between NAION patients and normal individuals.MethodsThis study included 22 acute NAION patients (25 eyes), 21 non-acute NAION patients (23 eyes) and 23 normal individuals (34 eyes). All study participants underwent swept-source optical coherence tomography to assess the vitreopapillary interface, peripapillary wrinkles and peripapillary superficial vessel protrusion. The statistical correlations between peripapillary superficial vessel protrusion measurements and NAION were analysed. Two NAION patients underwent standard pars plana vitrectomy.ResultsIncomplete papillary vitreous detachment was noted in all acute NAION patients. The prevalence of peripapillary wrinkles was 68% (17/25), 30% (7/23) and 0% (0/34), and the prevalence of peripapillary superficial vessel protrusion was 44% (11/25), 91% (21/23) and 0% (0/34) in the acute, non-acute NAION and control groups, respectively. The prevalence of peripapillary superficial vessel protrusion was 88.9% in the eyes without retinal nerve fibre layer thinning. Furthermore, the number of peripapillary superficial vessel protrusions in the superior quadrant was significantly higher than that in the other quadrants in eyes with NAION, consistent with the more damaged visual field defect regions. Peripapillary wrinkles and visual field defects in two patients with NAION were significantly attenuated within 1 week and 1 month after the release of vitreous connections, respectively.ConclusionPeripapillary wrinkles and superficial vessel protrusion may be signs of papillary vitreous detachment-related traction in NAION. Papillary vitreous detachment may play an important role in NAION pathogenesis.
Association of theCDKAL1gene polymorphism with gestational diabetes mellitus in Chinese women
Authors: Huang Chengjing , Guo Yan , Li Wei , Xiang Bing , Zeng Jing , Zhou Feng , She Lu , Zhang Pei , Wang Shiwei , Liu Bei , Dai Qiong , Yang Mei 
Published: April 2023

IntroductionTo identify the association of the cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 (CDKAL1) gene polymorphism with gestational diabetes mellitus (GDM) in the Chinese population.Research design and methodsThis case-control study enrolled 835 pregnant women with GDM and 870 pregnant women without diabetes who underwent antenatal examination during 24 to 28 gestational weeks at the Maternal and Child Health Hospital of Hubei Province from January 15, 2018 to March 31, 2019. Trained nurses collected their clinical information and blood samples.CDKAL1gene rs10440833, rs10946398, rs4712523, rs4712524, rs7754840, rs7756992 and rs9465871 loci were genotyped by Agena MassARRAY system. SPSS V.26.0 software and online SHesis were used to analyze the relationship betweenCDKAL1gene polymorphism and GDM susceptibility.ResultsAfter being adjusted for maternal age, prepregnancy body mass index (BMI), parity and family history of type 2 diabetes mellitus (T2DM),CDKAL1gene rs10440833 (AA vs TT, OR=1.631, 95% CI 1.192 to 2.232), rs10946398 (CC vs AA, OR=1.400, 95% CI 1.028 to 1.905), rs4712523(GG vs AA, OR=1.409, 95% CI 1.038 to 1.913), rs4712524 (GG vs AA, OR=1.418, 95% CI 1.043 to 1.929) and rs7754840 (CC vs GG, OR=1.407, 95% CI 1.036 to 1.911) polymorphisms were all associated with the increased risk of GDM. In addition, there was a powerful linkage disequilibrium (LD) among rs10946398, rs4712523, rs4712524 and rs7754840 (D′>0.900, r2>0.900). And there were significant differences in haplotype CGGC (OR=1.207, 95% CI 1.050 to 1.387) and AAAG (OR=0.829, 95% CI 0.721 o 0.952, p=0.008) between the GDM group and the control group.Conclusionsrs10440833, rs10946398, rs4712523, rs4712524 and rs7754840 ofCDKAL1gene are associated with GDM susceptibility in central Chinese population.
Exercise during CHemotherapy for Ovarian cancer (ECHO) trial: design and implementation of a randomised controlled trial
Authors: Hayes Sandra , Obermair Andreas , Mileshkin Linda , Davis Alison , Gordon Louisa G , Eakin Elizabeth , Janda Monika , Beesley Vanessa L , Barnes Elizabeth H , Spence Rosalind Renee , Sandler Carolina , Jones Tamara , Vagenas Dimitrios , Webb Penny , Andrews John , Brand Alison , Lee Yeh Chen , Friedlander Michael , Pumpa Kate , O’Neille Helene , Williams Merran ,   The ECHO Collaborative, Stockler Martin 
Published: April 2023

IntroductionEpidemiological evidence supports an association between higher levels of physical activity and improved cancer survival. Trial evidence is now needed to demonstrate the effect of exercise in a clinical setting. TheExercise duringCHemotherapy forOvarian cancer (ECHO) trial is a phase III, randomised controlled trial, designed to determine the effect of exercise on progression-free survival and physical well-being for patients receiving first-line chemotherapy for ovarian cancer.Methods and analysisParticipants (target sample size: n=500) include women with newly diagnosed primary ovarian cancer, scheduled to receive first-line chemotherapy. Consenting participants are randomly allocated (1:1) to either theexercise intervention(plus usual care) orusual carealone, with stratification for recruitment site, age, stage of disease and chemotherapy delivery (neoadjuvant vs adjuvant). The exercise intervention involves individualised exercise prescription with a weekly target of 150 minutes of moderate-intensity, mixed-mode exercise (equivalent to 450 metabolic equivalent minutes per week), delivered for the duration of first-line chemotherapy through weekly telephone sessions with a trial-trained exercise professional. The primary outcomes are progression-free survival and physical well-being. Secondary outcomes include overall survival, physical function, body composition, quality of life, fatigue, sleep, lymphoedema, anxiety, depression, chemotherapy completion rate, chemotherapy-related adverse events, physical activity levels and healthcare usage.Ethics and disseminationEthics approval for the ECHO trial (2019/ETH08923) was granted by the Sydney Local Health District Ethics Review Committee (Royal Prince Alfred Zone) on 21 November 2014. Subsequent approvals were granted for an additional 11 sites across Queensland, New South Wales, Victoria and the Australian Capital Territory. Findings from the ECHO trial are planned to be disseminated via peer-reviewed publications and international exercise and oncology conferences.Trial registration numberAustralian New Zealand Clinical Trial Registry (ANZCTRN12614001311640;https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=367123&isReview=true).
Improving employment outcomes for people with disability in small and medium enterprises: protocol for a scoping review
Authors: Keating Byron W , Worsteling Asha 
Published: April 2023

IntroductionImproving the employment of people with disability (PWD) has emerged as a key priority for governments worldwide as a strategy for improving health outcomes through greater economic participation. However, a significant barrier remains the lack of understanding among businesses regarding the requirements for a disability-inclusive workplace. This challenge is particularly salient for small and medium enterprises (SMEs) that lack dedicated human resources to develop supportive organisational cultures. This scoping review will assist smaller businesses in enhancing their capacity to employ PWD by undertaking a synthesis of the factors that will enhance SME capacity to hire and retain PWDs.Methods and analysisThis protocol uses the six-staged process for scoping reviews proposed by Arksey and O’Malley. This process begins with identifying the scoping review research question (Stage 1) and discussing how studies will be selected (Stage 2). The search will include all English-language articles within Web of Science, Scopus, PsycINFO, PubMed, Cochrane Library, Embase, Medline, EBSCO Global Health and CINAHL since inception. We will also include relevant secondary sources from the grey literature. Following the search process, we will present information on selecting studies for inclusion in the scoping review (Stage 3) and chart the data relating to the included studies (Stage 4). In conclusion, the scoping review protocol will synthesise and report the results (Stage 5) and provide information on consultation with relevant stakeholders during the initial protocol specifications (Stage 6).Ethics and disseminationSince the scoping review methodology aims at synthesising information from available publications, this study does not require ethical approval. We will submit an article reporting the results of the scoping review for publication in a scientific journal, present the findings at relevant conferences and disseminate them as part of future workshops with professionals in disability employment.
A little bit pregnant:towards a pluralist account of non-sexual reproduction
Authors: Hall Georgina Antonia 
Published: April 2023

Fertility clinicians participate in non-sexual reproductive projects by providing assisted reproductive technology (ART) to those hoping to reproduce, in support of their reproductive goals. In most countries where ART is available, the state regulates ART as a form of medical treatment. The predominant position in the reproductive rights literature frames the clinician’s role as medical technician, and the state as a third party with limited rights to interfere. These roles broadly align with established functions of clinician and state in Western liberal democracies, where doctors have duties to provide safe, beneficial and legal healthcare to all who seek it. Recognised state responsibilities include safeguarding equitable access to medical services and protecting and promoting reproductive liberty.I argue against this normative moral framing of clinician and state involvement in non-sexual reproduction, suggesting that clinician and state join the non-sexual reproductive project at the point of triggering conception. Begetting a child is more than just the provision and regulation of healthcare; it generates rights and confers responsibilities on all who join this morally significant project. All who collaborate have the right to join or refuse to join the project. I suggest this is intuitively understood in the sexual realm, but not in the non-sexual realm. My key substantive claim is that non-sexual reproduction is a pluralist pursuit that morally implicates more than the genetic and gestational contributors. I find that while the moral basis of a clinician or the state’s right to refuse to join the ART project is the same as for those providing gestational or genetic input, the reasons that morally underpin their refusal differs.
Strategic validation of variants of uncertain significance inECHS1genetic testing
Authors: Kishita Yoshihito , Sugiura Ayumu , Onuki Takanori , Ebihara Tomohiro , Matsuhashi Tetsuro , Shimura Masaru , Fushimi Takuya , Ichino Noriko , Nagatakidani Yoshie , Nishihata Hitomi , Nitta Kazuhiro R , Yatsuka Yukiko , Imai-Okazaki Atsuko , Wu Yibo , Osaka Hitoshi , Ohtake Akira , Murayama Kei , Okazaki Yasushi 
Published: April 2023

BackgroundEnoyl-CoA hydratase short-chain 1 (ECHS1) is an enzyme involved in the metabolism of branched chain amino acids and fatty acids. Mutations in theECHS1gene lead to mitochondrial short-chain enoyl-CoA hydratase 1 deficiency, resulting in the accumulation of intermediates of valine. This is one of the most common causative genes in mitochondrial diseases. While genetic analysis studies have diagnosed numerous cases withECHS1variants, the increasing number of variants of uncertain significance (VUS) in genetic diagnosis is a major problem.MethodsHere, we constructed an assay system to verify VUS function forECHS1gene. A high-throughput assay usingECHS1knockout cells was performed to index these phenotypes by expressing cDNAs containing VUS. In parallel with the VUS validation system, a genetic analysis of samples from patients with mitochondrial disease was performed. The effect on gene expression in cases was verified by RNA-seq and proteome analysis.ResultsThe functional validation of VUS identified novel variants causing loss ofECHS1function. The VUS validation system also revealed the effect of the VUS in the compound heterozygous state and provided a new methodology for variant interpretation. Moreover, we performed multiomics analysis and identified a synonymous substitution p.P163= that results in splicing abnormality. The multiomics analysis complemented the diagnosis of some cases that could not be diagnosed by the VUS validation system.ConclusionsIn summary, this study uncovered newECHS1cases based on VUS validation and omics analysis; these analyses are applicable to the functional evaluation of other genes associated with mitochondrial disease.
Contact patterns of UK home delivery drivers and their use of protective measures during the COVID-19 pandemic: a cross-sectional study
Authors: Bridgen Jessica R E , Wei Hua , Whitfield Carl , Han Yang , Hall Ian , Jewell Chris P , van Tongeren Martie J A , Read Jonathan M 
Published: April 2023

ObjectivesTo quantify contact patterns of UK home delivery drivers and identify protective measures adopted during the pandemic.MethodsWe conducted a cross-sectional online survey to measure the interactions of 170 UK delivery drivers during a working shift between 7 December 2020 and 31 March 2021.ResultsDelivery drivers had a mean number of 71.6 (95% CI 61.0 to 84.1) customer contacts per shift and 15.0 (95% CI 11.2 to 19.2) depot contacts per shift. Maintaining physical distancing with customers was more common than at delivery depots. Prolonged contact (more than 5 min) with customers was reported by 5.4% of drivers on their last shift. We found 3.0% of drivers had tested positive for SARS-CoV-2 since the start of the pandemic and 16.8% of drivers had self-isolated due to a suspected or confirmed case of COVID-19. In addition, 5.3% (95% CI 2.3% to 10.2%) of participants reported having worked while ill with COVID-19 symptoms, or with a member of their household having a suspected or confirmed case of COVID-19.ConclusionDelivery drivers had a large number of face-to-face customer and depot contacts per shift compared with other working adults during this time. However, transmission risk may be curtailed as contact with customers was of short duration. Most drivers were unable to maintain physical distance with customers and at depots at all times. Usage of protective items such as face masks and hand sanitiser was widespread.
Mechanisms of vocational interventions for return to work from musculoskeletal conditions: a mediation analysis of the MI-NAV trial
Authors: Cashin Aidan G , Øiestad Britt Elin , Aanesen Fiona , Storheim Kjersti , Tingulstad Alexander , Rysstad Tarjei Langseth , Lee Hopin , McAuley James H , Sowden Gail , Wynne-Jones Gwenllian , Tveter Anne Therese , Grotle Margreth 
Published: April 2023

ObjectivesTo investigate whether and to what extent, return to work (RTW) expectancy and workability mediate the effect of two vocational interventions on reducing sickness absence in workers on sick leave from a musculoskeletal condition.MethodsThis is a preplanned mediation analysis of a three-arm parallel randomised controlled trial which included 514 employed working adults with musculoskeletal conditions on sick leave for at least 50% of their contracted work hours for ≥7 weeks. Participants were randomly allocated (1:1:1) to one of three treatment arms; usual case management (UC) (n=174), UC plus motivational interviewing (MI) (n=170) and UC plus a stratified vocational advice intervention (SVAI) (n=170). The primary outcome was the number of sickness absence days over 6 months from randomisation. Hypothesised mediators included RTW expectancy and workability assessed 12 weeks after randomisation.ResultsThe mediated effect of the MI arm compared with UC on sickness absence days through RTW expectancy was −4.98 days (−8.89 to −1.04), and workability was −3.17 days (−8.55 to 2.32). The mediated effect of the SVAI arm compared with UC on sickness absence days through RTW expectancy was −4.39 days (−7.60 to −1.47), and workability was −3.21 days (−7.90 to 1.50). The mediated effects for workability were not statistically significant.ConclusionsOur study provides new evidence for the mechanisms of vocational interventions to reduce sickness absence related to sick leave due to musculoskeletal conditions. Changing an individual’s expectation that RTW is likely may result in meaningful reductions in sickness absence days.Trial registration numberNCT03871712.
The most important theoretical developments leading to the current understanding of heavy-element stability
Authors: Möller Peter 
Published: April 2023

AbstractWe discuss the sequence of developments that over the past 90 years led to current insights on heavy-element stability. The semi-empirical mass model, and its extension to deformed shapes, developed in the period 1936–1950 allowed the interpretation of nuclear fission. Around 1950 the spherical single-particle model was developed, soon after with extension to deformed nuclei. Speculations about a shell-stabilized region of spherical heavy elements near $$Z=126$$

Z
=
126

were made. In the 1960ies Strutinsky combined the single-particle and macroscopic liquid-drop models into a unified picture, the shell-correction, or macroscopic-microscopic method. Now it was also realized that although $$Z=126$$

Z
=
126

was present, an often stronger spherical gap in calculated proton single-particle level diagrams, $$Z=114$$

Z
=
114

, was also present, but its significance had previously been overlooked. A large number of studies of the stability of nuclei in the “shell-stabilized” region surrounding $$Z=114$$

Z
=
114

and $$N=184$$

N
=
184

followed. Initially the assumption was that elements just beyond the actinides, would be too unstable to be observed. The 1970ies saw considerable work in refining the initial single-particle and macroscopic models. This set the stage for global studies, which took off in the 1980ies and have continued until today. The more accurate nuclear-structure models allowed calculations of masses, decay-chain properties and branching between different decay modes to useful accuracy and predictive quality. A completely unexpected result was that the calculations showed the existence of an area of relatively stable deformed nuclei in the presumed “sea of instability” between the actinides and the next postulated spherical magic numbers.