bluuebunny/crossref_metadata_2025_split huggingface dataset:
Confucianism and Transgenerational Grounds for Justice
Authors: Sim May 
Published: June 2023

Abstract
This article explores Mencius’s virtue-oriented ethics and its metaphysical foundation for resources they can provide to transgenerational communities. Mencius’s ethics offers moral norms for human actions that transcend those generations with whom they can interact and impact generations of people in the future. These actions range from the preservation of traditional values to the challenges of climate change, offering grounds for transgenerational justice. Mencius’s account of virtues offers a moral justification for the standards of living that are common to all human beings, justifying their entitlements to certain economic, social, cultural, and environmental conditions for the cultivation of moral virtues that perfect human nature. Due to his view that the metaphysics of human nature also governs the cosmic world, the virtues that govern good human relationships will also protect the world’s natural resources, regardless of whether someone subscribes to a Confucian community.
When the Generational Overlap Is the Challenge Rather Than the Solution. On Some Problematic Versions of Transgenerational Justice
Authors: Menga Ferdinando G 
Published: June 2023

Abstract
While in the realm of scholarly debate on intergenerational justice the mechanism of a transgenerational intertwinement has been often adopted as a chief conceptual device in view of overcoming ethical short-termism and legitimizing duties towards future generations, this paper aims at showing that there are good reasons for considering the opposite outcome. Drawing on three paradigmatic examples taken from three mainstream approaches in the debate—Rawls’s contractualism, Gauthier’s contractarianism, and indirect reciprocity—I will show how the grammar of presentism is still largely operative under the surface of theories explicitly recurring to such a device and thereby advocating a chain of duties capable to reach the remote future. A short closing section will be devoted to endorsing a radical reorientation in ethics, such that a direct link to future invocations will be considered as a promising strategy for genuinely justifying intergenerational obligations.
Group Immortality and Transgenerational Meaning
Authors: Dean Matt 
Published: June 2023

Abstract
Excessive boredom and the inevitability of experiencing a very bad event are two commonly cited objections to the desirability of individual immortality. It isn’t clear, however, that these objections hold weight in the context of group lives—like the lives of reading groups or labor unions. I argue that this intuition is correct: neither of the objections to an immortal individual life apply to the life of an immortal group. In the end, we may not be able to wish immortality for ourselves, but we can and often should desire that good group lives go on forever, both for the sake of the group and the individuals that constitute them. Indeed, participation in immortal (or very long-lasting) groups is one way to add meaning to life.
Synovial fluid crystal analysis with compensated polarization using a gout analyser in clinical practice
Authors: Kise Takayasu , Yokogawa Naoto , Miyoshi Yuji , Utsunomiya Masako , Nagai Yoshiki , Shimada Kota 
Published: June 2023

ABSTRACT

Objective
To validate the gout analyzer as a clinical method of synovial fluid crystal analysis.

Methods
Thirty knee synovial fluid samples with suspected calcium pyrophosphate (CPP) crystals were analyzed. Within 48 hours after collection, each non-centrifuged sample was examined blindly and independently by one or more rheumatologists in the following order: 1) with an optical microscope under ordinary light, 2) with the same microscope under compensated polarization provided by a gout analyzer, and 3) with a fully equipped compensated polarized microscope with a rotating stage as the gold standard. As a reference, laboratory technicians analyzed fresh, centrifuged synovial fluid using a gout analyzer.

Results
Of the 30 samples analyzed, CPP and monosodium urate (MSU) crystals were detected in 11 and four, non-centrifuged samples, respectively, using a fully equipped compensated polarized microscope. The rheumatologists’ detection rate of crystals in the non-centrifuged synovial fluid under ordinary light and with a gout analyzer was 73.3% and 80%, respectively. The laboratory technicians’ detection rate in fresh centrifuged synovial fluid using a gout analyzer was 100%.

Conclusion
A gout analyzer may be used to diagnose gout and calcium pyrophosphate deposition disease definitively if a fully equipped compensated polarized microscope is unavailable.
Smoking Cessation Interventions and Abstinence Outcomes for People Living in Rural, Regional, and Remote Areas of Three High-Income Countries: A Systematic Review
Authors: Trigg Joshua , Skelton Eliza , Lum Alistair , Guillaumier Ashleigh , McCarter Kristen , Handley Tonelle , Judd Lucy , Lye Alexie , Bonevski Billie 
Published: June 2023

Abstract

Introduction
Tobacco smoking rates in high-income countries are greater in rural, regional, and remote (RRR) areas compared to cities. Yet, there is limited knowledge about interventions targeted to RRR smokers. This review describes the effectiveness of smoking cessation interventions for RRR smokers in supporting smoking abstinence.

Aims and Methods
Seven academic databases were searched (inception-June 2022) for smoking cessation intervention studies to include if they reported on RRR residents of Australia, Canada, or the United States, and short- (&lt;6 months) or long-term (≥6 months) smoking abstinence outcomes. Two researchers assessed study quality, and narratively summarized findings.

Results
Included studies (n = 26) were primarily randomized control (12) or pre-post (7) designs, from the United States (16) or Australia (8). Five systems change interventions were included. Interventions included cessation education or brief advice, and few included nicotine monotherapies, cessation counseling, motivational interviewing, or cognitive behavioral therapy. Interventions had limited short-term effects on RRR smoking abstinence, decreasing markedly beyond 6 months. Short-term abstinence was best supported by contingency, incentive, and online cessation interventions, and long-term abstinence by pharmacotherapy.

Conclusions
Cessation interventions for RRR smokers should include pharmacotherapy and psychological cessation counseling to establish short-term abstinence, and identify effective means of maintaining abstinence beyond 6 months. Contingency designs are a suitable vehicle for psychological and pharmacotherapy support for RRR people who smoke, and intervention tailoring should be explicitly considered.

Implications
Smoking disproportionately harms RRR residents, who can encounter access barriers to smoking cessation support. High-quality intervention evidence and outcome standardization are still required to support long-term RRR smoking abstinence.
Anlotinib Combined With Toripalimab as First-Line Therapy for Unresectable Hepatocellular Carcinoma: A Prospective, Multicenter, Phase II Study
Authors: Zhang Cheng-Sheng , Zeng Zhi-Ming , Zhuo Man-Yun , Luo Jing-Ru , Zhuang Xiao-Hong , Xu Jun-Nv , Zeng Jie , Ma Jie , Lin Hai-Feng 
Published: June 2023

Abstract

Background
For patients with unresectable hepatocellular carcinoma (HCC), the first-line therapeutic options are still relatively limited, and treatment outcomes remain poor. We aimed to assess the efficacy and safety of anlotinib combined with toripalimab as first-line therapy for unresectable HCC.

Methods
In this single-arm, multicenter, phase II study (ALTER-H-003), patients with advanced HCC without previous systemic anticancer therapy were recruited. Eligible patients were given anlotinib (12 mg on days 1-14) combined with toripalimab (240 mg on day 1) in a 3-week cycle. The primary endpoint was the objective response rate (ORR) by immune-related Response Evaluation Criteria in Solid Tumours (irRECIST)/RECIST v1.1 and modified RECIST (mRECIST). Secondary endpoints included disease control rate (DCR), duration of response (DoR), progression-free survival (PFS), overall survival (OS), and safety.

Results
Between January 2020 and Jul 2021, 31 eligible patients were treated and included in the full analysis set. At data cutoff (January 10, 2023), the ORR was 29.0% (95% CI: 12.1%-46.0%) by irRECIST/RECIST v1.1, and 32.3% (95% CI: 14.8%-49.7%) by mRECIST criteria, respectively. Confirmed DCR and median DoR by irRECIST/RECIST v1.1 and mRECIST criteria were 77.4 % (95% CI: 61.8%-93.0%) and not reached (range: 3.0-22.5+ months), respectively. Median PFS was 11.0 months (95% CI: 3.4-18.5 months) and median OS was 18.2 months (95% CI: 15.8-20.5 months). Of the 31 patients assessed for adverse events (AEs), the most common grade ≥ 3 treatment-related AEs were hand-foot syndrome (9.7%, 3/31), hypertension (9.7%, 3/31), arthralgia (9.7%, 3/31), abnormal liver function (6.5%, 2/31), and decreased neutrophil counts (6.5%, 2/31).

Conclusions
Anlotinib combined with toripalimab showed promising efficacy and manageable safety in Chinese patients with unresectable HCC in the first-line setting. This combination therapy may offer a potential new therapeutic approach for patients with unresectable HCC.
Turkey Vulture survival is reduced in areas of greater road density
Authors: Naveda-Rodríguez Adrián , Bildstein Keith L , Barber David R , Therrien Jean-François , Avery Michael L , Kluever Bryan M , Rush Scott A , Vilella Francisco J 
Published: June 2023

Abstract
The demography of, and factors that influence these metrics, are largely unknown for most vultures in the Americas. Survivorship of Turkey Vultures (Cathartes aura) may be influenced by landscape heterogeneity and human disturbance. We quantified the effects of landscape composition (Shannon’s diversity index) and configuration (contagion, edge density, and largest patch index), and human disturbance (road density) on the annual and seasonal survival probabilities of the three North American breeding populations (western, central, and eastern) of Turkey Vultures that spend the nonbreeding season in the southeastern portion of the Nearctic and the northern Neotropics during a 17-year period. We used Cox’s proportional hazards models with time-varying covariates to estimate spatial and temporal changes in survival rates of adult Turkey Vultures. Road density, but not landscape composition or configuration, influenced survival rates in space and time. Overall annual survival averaged 0.87 (95% confidence interval [CI]: 0.74–0.98). Mortality risk was low in western and central populations (hazard ratio &lt; 1) but was 3.7 times greater for vultures in the eastern population. Survival during the breeding (0.97, 95% CI: 0.96–0.98) and outbound migration (1.0, 95% CI: 1–1) seasons was significantly higher than the other seasons. Average survival tended to be higher for nonbreeding (0.81, 95% CI: 0.71–0.88) compared to return migration (0.69, 95% CI: 0.56–0.81) seasons. The risk of mortality for all vulture populations increased with road density, and this was greater during the nonbreeding and return migration seasons. The spatial variation in road density across the Americas may generate a network of ecological traps for Turkey Vultures induced to stop in areas of greater road-kill abundance. Road-killed animals acting as an attractant for vultures can increase the occurrence of vulture–vehicle collisions and potentially aggravate human–wildlife conflicts. Further analyses are needed to address survivorship and mortality factors for young birds. Our results may help the implementation of specific mitigation efforts to reduce human–vulture conflicts and vulture mortality. For instance, concentrating efforts to remove road-killed animals in areas where road density is highest can likely reduce vulture–vehicle collisions and associated mortalities of these birds.
Aetiologies of low alkaline phosphatase in a Canadian Paediatric Tertiary Care Centre
Authors: Sbrocchi Anne Marie , Cavin Rosalie , Marleau Annie , Fournier Tanya , Beecroft Michael , Ferraz dos Santos Beatriz 
Published: June 2023

Abstract

Objectives
Increasingly, laboratories flag low serum alkaline phosphatase (sALP) that are age-and sex-specific in paediatrics. The aim of this study was to report clinical manifestations of paediatric patients with age-and sex-specific low sALP, thereby increasing awareness of its potential aetiologies.

Methods
This retrospective Canadian tertiary care paediatric hospital study assessed all sALP of ambulatory patients aged less than 18 years from 2015 to 2017. The hospital used a Beckman Coulter AU assay to measure sALP and compared values to the Canadian age-and sex-specific reference intervals from CALIPER. All children who had at least one subnormal age-and sex-specific sALP were evaluated. A review of medical charts of included patients was performed and demographic characteristics, medical history and diagnosis were collected, and categorized under groups of medical disorders.

Results
Of 11,874 included patients, 1,001 patients (9.2%) had low sALP. Of those, 48% (485/1,001) had transient low sALP activity and 9.6% (96/1,001) had persistently low sALP. Prolonged immobilization and inflammatory bowel disease represented the main aetiologies for persistently low sALP. Interestingly, 13.5% (13/96) of patients with persistently low sALP had no apparent aetiology.

Conclusions
Our results report aetiologies of low sALP in a Canadian paediatric population using age-and sex-specific Canadian reference ranges. This study highlights that healthcare providers should be aware that a low sALP may have clinical significance and should be repeated if warranted based on further clinical assessment.
Nucleotide Limitation Results in Impaired Photosynthesis, Reduced Growth and Seed Yield Together with Massively Altered Gene Expression
Authors: Bellin Leo , Melzer Michael , Hilo Alexander , Garza Amaya Diana Laura , Keller Isabel , Meurer Jörg , Möhlmann Torsten 
Published: June 2023

Abstract
Nucleotide limitation and imbalance is a well-described phenomenon in animal research but understudied in the plant field. A peculiarity of pyrimidine de novo synthesis in plants is the complex subcellular organization. Here, we studied two organellar localized enzymes in the pathway, with chloroplast aspartate transcarbamoylase (ATC) and mitochondrial dihydroorotate dehydrogenase (DHODH). ATC knock-downs were most severely affected, exhibiting low levels of pyrimidine nucleotides, a low energy state, reduced photosynthetic capacity and accumulation of reactive oxygen species. Furthermore, altered leaf morphology and chloroplast ultrastructure were observed in ATC mutants. Although less affected, DHODH knock-down mutants showed impaired seed germination and altered mitochondrial ultrastructure. Thus, DHODH might not only be regulated by respiration but also exert a regulatory function on this process. Transcriptome analysis of an ATC-amiRNA line revealed massive alterations in gene expression with central metabolic pathways being downregulated and stress response and RNA-related pathways being upregulated. In addition, genes involved in central carbon metabolism, intracellular transport and respiration were markedly downregulated in ATC mutants, being most likely responsible for the observed impaired growth. We conclude that impairment of the first committed step in pyrimidine metabolism, catalyzed by ATC, leads to nucleotide limitation and by this has far-reaching consequences on metabolism and gene expression. DHODH might closely interact with mitochondrial respiration, as seen in delayed germination, which is the reason for its localization in this organelle.
Invisible scars: exploring the impact of childhood left-behind experience on children’s emotional development and well-being
Authors: Padillah Raup , Suhardita Kadek , Hidayah Nur , Ramli M 
Published: June 2023

Abstract
Childhood trauma experience and mental health issues can significantly impact children’s emotional development and overall well-being. It is crucial to recognize and address the invisible scars left by childhood left-behind experience. By acknowledging the impact of childhood left-behind experience and providing appropriate support and interventions, we can help these children to heal, thrive and develop into emotionally resilient individuals.
Diffraction by a Right-Angled No-Contrast Penetrable Wedge: Analytical Continuation of Spectral Functions
Authors: Kunz V D , Assier R C 
Published: June 2023

Summary
We study the problem of diffraction by a right-angled no-contrast penetrable wedge by means of a two-complex-variable Wiener–Hopf approach. Specifically, the analyticity properties of the unknown (spectral) functions of the two-complex-variable Wiener–Hopf equation are studied. We show that these spectral functions can be analytically continued onto a two-complex dimensional manifold, and unveil their singularities in C2. To do so, integral representation formulae for the spectral functions are given and thoroughly used. It is shown that the novel concept of additive crossing holds for the penetrable wedge diffraction problem, and that we can reformulate the physical diffraction problem as a functional problem using this concept.
‘Cant About Decorum’: George Thomson’s Singular Edition of Robert Burns’s ‘The Jolly Beggars’
Authors: McCue Kirsteen , McKeever Gerard Lee 
Published: June 2023

Abstract
Robert Burns’s song editor George Thomson (1757–1851) issued the poet’s cantata ‘Love and Liberty’, also known as ‘The Jolly Beggars’, for the first time with music in 1818 (a setting of Burns’s text for narrator, solo singers, choir, and piano trio). The musical score was by London theatre composer Sir Henry Bishop and the text was edited by Thomson in line with his strict policy of decency and politeness. This essay tracks Thomson’s editorial curation of Burns’s text in the context of polite ‘improvement’ and argues that while pursuing apparent ‘decorum’, Thomson’s treatment struggles to negotiate the unruliness at the centre of what is now considered one of Burns’s most important works. The article pays particular attention to the complicated publication history of this work, revealing a chronology of popular print editions in advance of Thomson’s own, as well as the notable influence of Walter Scott’s remarks on the piece in the Quarterly Review. Examining the musical context of Thomson’s ‘Jolly Beggars’ alongside the text reveals a similar aspiration for elevation and the article presents the conversation between Thomson and Bishop, from manuscript correspondence.
Institutional logics in the open science practices of university–industry research collaboration
Authors: Lattu Annina , Cai Yuzhuo 
Published: June 2023

Abstract
As an emerging agenda in science and public policy discourse, the open science (OS) movement has affected university–industry research collaboration (UIRC) including normative changes concerning actors’ value and belief systems. Thus, the following questions have become pertinent: what are the norms and beliefs of key actors engaged in UIRC regarding OS practices? How have the norms and beliefs led to tensions in UIRC and dynamics facilitating or impeding OS? This study explores these questions through two case studies by applying institutional logics theory as an analytical lens. Through analysing case studies concerning UIRC in Finland, a pioneer in the global OS movement, six institutional logics that are either pro- or contra-OS practices were identified: the state, market, corporation, profession, traditional trust–based community and sustainability-based community logics. The strongest tensions are between the state and market logics and between the profession and market logics. In the end of the study, recommendations are solicited for OS policymakers and practitioners based on the research findings.
Structural Stigma and 7-Year Improvement in Life Satisfaction among Diverse Groups of Sexual Minority Individuals: A Repeated Cross-Sectional Study across 28 Countries
Authors: Bränström Richard , Pachankis John E 
Published: June 2023

Abstract
Structural stigma toward sexual minority individuals, in the form of discriminatory laws and prejudicial population attitudes, varies widely across countries and is associated with psychosocial health outcomes. Yet, the association of changes in country-level structural stigma over time, as has recently characterized many European countries, with such outcomes is largely unknown. Using data from sexual minority respondents (2012: n=82,668; 2019: n=96,576) living in 28 European countries, this study analyzes the association between change in structural stigma from 2012 to 2019 and change in life satisfaction among sexual minority individuals during the same period. Results showed that life satisfaction had improved among sexual minority individuals in all countries between 2012 and 2019 (β = 0.33, 95% confidence interval: 0.30, 0.36), but the improvement was stronger among those living in higher-stigma, compared to lower-stigma, countries and more as a function of changing laws than attitudes. Changes also varied by relationship status; the strongest improvement in life satisfaction as a function of decreased structural stigma was found among partnered sexual minority individuals. The findings support the relevance of structural stigma for sexual minority individuals’ life satisfaction and call for further research to understand the differential impact of structural stigma across sexual minority subgroups.
Intergenerational transfer of (family) companies via the French preferential “Pacte Dutreil” tax regime
Authors: Jolk Christophe , Schweitzer Claire 
Published: June 2023

Abstract
Transferring shares in a commercially operating company via donation or inheritance can lead to a significant tax burden, which in turn sometimes forces the beneficiaries to sell some of the shares received to pay their taxes. France thus has a preferential tax regime, allowing such donations or inheritances to be tax exempt at 75% of the transferred value. This preferential tax regime is often sought in family-owned companies, where the control of the business is thus better retained for the following generations, which generally leads to a greater stability of the company and hence to greater job security for its employees over time.