bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational Identification of New Inhibitors for 3C-Like Protease: A Potential Drug Target in Coronavirus
Authors: Numan Muhammad Numan , Ajmal Amar , Iqra Iqra Akbar , Mubassir Shah Syed Mubassir Shah , Ali Arif 
Published: February 2025

SARS CoV-2 is a single-strand RNA, positive sense and enveloped beta coronavirus that causes respiratory, nervous, hepatic, and human gastrointestinal diseases. Due to the presence of spike glycoprotein, it appears crown or corona-like. SARS-CoV-2 is more contagious and has caused more deaths and infections. Old-age people and immune-compromised patients face the greatest risk of death. The main protease (Mpro), also known as the 3CL pro, is responsible for virus replication. Because it differs from human proteases, the main protease of SARS-CoV-2 is considered to be an attractive target for drugs. The process of developing a new drug is difficult, time-consuming, expensive, and usually takes more than ten years and billions of dollars. On the other hand, computer-aided techniques have accelerated the process of drugs. The present study aims to identify new inhibitors for the Main protease. The South African natural compound database containing 1012 compounds was docked against the Main protease. The compound with a good docking binding energy score was simulated for a total of 100 ns, and the result was compared with the control compound. The compound SANC00361 had a binding energy score of -7.30 Kcal/mol. The compound SANC00361 was found to be more stable as compared to the control compound. The identified compound SANC00361 may possess the potential to inhibit the Mpro of SARS CoV-2 and can be helpful in treating SARS CoV-2-associated infections.
MOTORCYCLE OVERSPEEDING DETECTION SYSTEM WITH GPS TRACKING AND SMS NOTIFICATION
Authors: Obiso Jun-Jun , Aparre Lhiera , Balboa Levi Hector , Ybanez Eugene 
Published: February 2025

Overspeeding of motorcycles is the primary cause of motorcycle-related accidents in the Philippines. Motorcycle drivers are usually unaware that the normal speed limit has been exceeded during driving. To address this problem, a system has been developed to detect overspeeding by using a Hall Effect sensor. This system alerts the driver in times of overspeeding using a buzzer. Also, the system can provide location details of the motorcycle by using the Global Positioning System (GPS) module. These details can be sent to the dedicated user via Short Message Service (SMS) and can be stored using a Secure Digital (SD) card. In testing the performance of the developed system, the following experiments were performed in three different locations within Cebu, Philippines: GPS response test, Hall Effect sensor response test, and data logging test. Experiment results had proven that the developed system could effectively perform its desired operations. Specifically, it detects overspeeding, sends the location details via Short Message Service (SMS) messages to the dedicated user, alarms the buzzer when the speed limit is reached, and stores the information details using the SD card. Hence, the system advances the literature since it serves a dual purpose: to detect overspeeding and to track the location of motorcycles. For further enhancement of the system performance, it is highly recommended that future researchers should include an intelligent feature such as the automatic deceleration when the driving speed exceeds the speed limit. It would also be preferable if the collision detection and avoidance mechanisms can be incorporated.
SENSORY QUALITY OF COFFEE-LIKE BEVERAGE MADE FROM MUNG BEANS [Vigna radiata (L.) R. Wilczek]
Authors: Gayas Neslie P. , Cimafranca Lynette C. 
Published: February 2025

Mungbean is a common commodity in the Philippines with limited use as a consumer good. Hence, this study aimed to develop a coffee-like beverage from mungbeans. Specifically, it aimed to evaluate the sensory quality of the product as affected by different roasting time, as well as assess its acceptance to consumers. A single factor experiment arranged in Completely Randomized Design (CRD) in two replications with six treatments (10, 15, 20, 25, 20, and 35 minutes) of the varying roasting time were used. Sensory evaluation was done to determine the acceptability of the product in terms of color, aroma, sweetness, and bitterness using a sensory panel. Acceptability ratings of the sensory attributes were subjected to Analysis of Variance (ANOVA). The consumer acceptance test was subjected to the chi-square test. ANOVA showed that the different levels of roasting time had no significant effect on the acceptability of the product. The consumer preference test showed that 52% of the consumers preferred the product, while 48% preferred its commercial product. The study revealed that the formulated product could compete in the market.
Response of Mungbean (Vigna radiata (L.) Wilczek) to the Combined Application of Carabao Manure and Inorganic Phosphorus in Calcareous Soil
Authors: Capote Mary Joyce J. , BaÅˆoc Dionesio M. 
Published: February 2025

Proper fertilization in calcareous soil is necessary to enhance higher crop productivity. This was evaluated through a study that aimed to determine the outcome of the blended application of carabao dung and synthetic phosphorus on the response of mungbean in calcareous soil. To evaluate the correct amount of the blended application of aforesaid materials for effective growth and high seed yield of mungbean grown in calcareous soil. The experiment adopted six treatments such as T0 = No fertilizer application (control), T1 = 30-30-30 kg ha-1 N, P2O5, K2O, T2 = 2.5 t ha-1 carabao manure, T3 = 2.5 t ha-1 carabao manure + 10 kg ha-1 P2O5, T4 = 2.5 t ha-1 carabao manure + 20 kg ha-1 P2O5, and T5 = 2.5 t ha-1 carabao manure + 30 kg ha-1 P2O5. This was laid out in a Complete Randomized Design (CRD) with three replications. Soil analysis revealed that phosphorus application with carabao dung promoted the accumulation of soil organic phosphorus. Statistical analysis showed significant effects (p â‰¥ 0.01 & p â‰¥ 0.05) was achieved in all parameters gathered except on the period from sowing to heading and maturity, the production of seeds pod-1, root: shoot ratio, and harvest index. The blended application of carabao dung (2.5 t ha-1) and inert phosphorus regardless of dosage produced a remarkably higher number of pods plant-1 (6.13 â€“ 11.53 podsÂ±0.0000) and higher seed yield (0.70 to 1.40 g plant-1Â±0.0001) than unfertilized control. The combined application of carabao dung (2.5 t ha-1) and synthetic phosphorus (30 kg ha-1) is an appropriate fertilization strategy for mungbean production in calcareous soil to affect higher productivity.
The Business of Bitcoinsâ€™ Appreciated Allure, with the Glint of Regulation: A Review
Authors: Barry Dr. Todd J. 
Published: February 2025

This systematic review article analyzes that a feature missing in the common economic conditions for money is the â€œallureâ€ or â€œappreciationâ€ of it, with specific application to the history of money, the rise of bitcoins, their technological advancement, the potential of future regulation, and the overall future possibilities of money. Are bitcoins a commodity, an investment, a speculative asset, a fiat currency, or all of the above? A substantial literature review is first conducted, to scrutinize what is the general scholarly consensus, and whether bitcoins are better suited for such speculation or investment by managers and citizens. These conceptual questions are then thoroughly surveyed through additional research, using: descriptive statistics; bitcoinsâ€™ celebrity endorsements; and an analysis of bitcoinsâ€™ technological requirements, such as its energy usage, as well as its ability for record keeping, all while considering regulations and future currency development. The article generally finds, from consensus, and from its own analysis, that due to allure, but also due to traditional standards, that the future economy will use more technological forms and features of money, and that the definition of money itself will become even more complex.
POTENTIAL OF KOROT (Dioscorea hispida Dennst.) TUBERS AS A FEEDSTOCK FOR BIOETHANOL PRODUCTION
Authors: Olaco Ansherina , Amistoso Kristel Grace , Cardoso Evelyn 
Published: February 2025

Dioscorea hispida Dennst., locally referred to as "Korot" in some parts of Eastern Visayas, Philippines, is a species of yam known for its intoxicating property due to its reportedly high dioscorine content. Since the present use for food of D. hispida is continuously hampered by the poisonous nature of the tubers, this work investigates the potential of Korot as an alternative bioethanol feedstock. The study followed a specified experimental design in converting Korot starch into bioethanol using three (3) different Korot concentrations (5, 10, 15 % w/w), in dry basis, performed in triplicate. The process consisted of three main phases: gelatinization, liquefaction, and simultaneous saccharification and fermentation (SSF). Samples were gelatinized for sixty (60) minutes, followed by forty (40) minutes of liquefaction with the enzyme Î±-amylase (1000U/g), and 144 h of SSF with enzyme glucoamylase (50,000U/g) and Saccharomyces cerevisiae, with no enzyme recovery. The bioethanol yield calculation was based on the estimated substrate consumption during SSF. After 144 hours of SSF, the highest ethanol productivity and bioethanol yield obtained are 0.293 g/Lh-1 and 19.35%, respectively, both observed in the processing of the sample with the highest initial Korot concentration (15% w/w). The ANOVA results showed that there exists a statistical significance (p â‰¤ 0.05) between the initial Korot concentration present in the sample and both the ethanol productivity and bioethanol yield. The results of this study confirmed that Korot is a suitable raw material in producing bioethanol through SSF, and thus has the potential to be an alternative bioethanol feedstock.
LAMBANOG ALTERNATIVE PRODUCTION FROM CATALYZED FERMENTATION AND DISTILLATION OF SWEET POTATO (Ipomoea batatas L.) WITH COCONUT (Cocos nucifera L.) SAP
Authors: Son Mharc Jonaelle , Aboy Ben Arthur , Pastor Nathaniel Jey , Quiza Carl Marvin , Cardoso Evelyn 
Published: February 2025

Spirits are alcoholic beverages obtained from distilling fermented wines, usually made from grains, fruits, and other ingredients rich in carbohydrates. In the Philippines, obtaining these materials for local production, especially for the sought-after grape-based wines, are either difficult to grow or expensive to acquire. The country produces liquors known as lambanog and tuba, made from the sap of coconut (Cocos nucifera L.) trees. However, coconut is one of the major export products of the Philippines, and tapping the sap will prevent the tree from producing the fruits. Moreover, coconut trees provide various products; thus, lambanog production from the sap poses major competition in the agricultural sector. This study then aims to determine the suitability of sweet potato (Ipomea batatas L.) as alternative raw material for lambanog production through catalyzed fermentation and distillation. The experiment designed formulations A, B, and C using yeast (Saccharomyces cerevisiae)-coconut sap suspension ratio of 1:10 (grams, yeast: mL, coconut sap) to 350, 400, and 500 grams of sweet potato, respectively. Results showed a direct relationship between percent alcohol by volume (% ABV) and the mass of sweet potato. Formulation C (20.95%) has the highest average % ABV compared to A (19.28%) and B (20.49), but all three passed the typical minimum range (15-25% ABV) expected of the first distillation of fermented wines, making the sweet potato liquor suitable to proceed for 2nd distillation for alcohol optimization. For future commercialization, Formulation A is practical in producing a cost-effective but quality lambanog, but formulation C is the best alternative regarding % ABV.
Non-Destructive Testing in Sustainable Bio Energy: A Critical Review
Authors: Perera Hasith , Hosan K.S  , Priyadarshana H.V.V  , Wijesekara R.J.M.D.D.P  , Koswattage K.R  
Published: February 2025

The non destructive approach has increasingly played its roles in ensuring the set character of sustainability, reliability and safety in recent bio energy system. This review established the contribution that the non destructive methodologies could make in developing environmental sustainability and improving their effectiveness in operations through the evaluation of key developments and their various applications within the sectors. NDT methods such as Thermographic testing ,visual testing, Ultrasonic testing and EDDY current testing have their respective applications that enable the detection of surface and subsurface flows without sacrificing material integrity and hence guarantee continuous production processes .NDT has played a very important role in the evaluation of structural integrity in reactors ,pipelines, and storage systems in the production of biomass and biofuel to minimize the risk of catastrophic failures and environmental non destructive ,Digital twin systems and artificial intelligent constitute some emergence technologies which will definitely change the real time monitoring and predictive maintenance landscape of NDT .Such developments as wireless solutions and drone based inspections help NDT reach potentially dangerous or inaccessible areas. Despite the gains ,NDT adoption within bioenergy faces a wide array of challenges :Implementation costs, specialized training of personnel and integration within current work flows .These disadvantages ,On the other hand ,present a very fine avenue of study and collaboration for the advancement of the NDT techniques. This analysis underline the strategic importance of NDT for technological innovation ,the increase in sustainability and reduction of environmental impacts inside the bio energy sector ,thus it is one of the mainstays of the energy infrastructure for the future .
Effect of Artificial Intelligence (AI-ChatGPT) on Educational Psychology Students’ Engagement, Interest and Achievement in the Institute of Education, University of Abuja, Abuja, Nigeria
Authors: Kumo GIDADO, Bello , Hassan ZUBAIR, Taiye 
Published: February 2025

The study examined the effect of artificial intelligence (AI-ChatGPT) on educational psychology students’ engagement, interest and achievement in the Institute of Education, University of Abuja. Six research questions and six hypotheses guided the study. The research employed a quasi-experimental design. The sample of the study was 519. The reliability of the instruments was established using Kuder-Richardson formula (KR-21) which yielded a reliability index of 0.80. The data collected was analyzed using mean scores, standard deviation and the Two-tailed t-test analysis. Findings from the study showed that there was significant difference in the engagement mean scores of 200L students taught Educational Psychology I with AI-ChatGPT and those taught with conventional lecture method. It was also found that there is no significant difference in the interest mean scores of 200L students taught Educational Psychology I with AI-ChatGPT and those taught with conventional lecture method was found. The results further revealed that there was significant difference in the achievement mean scores of 200L students taught Educational Psychology I with AI-ChatGPT and those taught with conventional lecture method; just as a significant difference in the engagement mean scores of 200L male and female students taught Educational Psychology I with AI-ChatGPT and those taught with conventional lecture Based on the findings, the study recommended that AI-ChatGPT should be incorporated into the education curriculum in higher institution. The essence is to advance effective teaching and learning approaches for teachers and students.
The Evolution of Consumer Trust in E-Commerce: Exploring Digital Strategies for Enhanced Loyalty
Authors: Younis Karam Kamal , Zeebaree Subhi R. M. 
Published: February 2025

This review titled (The Evolution of Consumer Trust in E-Commerce: As evidenced in the article entitled Consumer Trust Dynamics in the Era of Digital Technologies: Uncovering Digital Approaches for Improving Loyalty, the development of consumer trust in e-commerce has emerged as a key influence in the new generation of fragmented business web environments. The research question of this paper is to establish how the use of digital tactics impacts consumer trust and improves loyalty in the growing market of e-commerce industry. The main issue stems from the high level of doubt from the consumers about the safety of their important information and personal data, fraud that affects loyalty towards the online purchase. This study aims at examining various digital communication strategies with the aim of determining which of them facilitates the building of trust; This is achieved through examining transparency in communication, proper addressing of user needs, adequate security measures and efficient management of customers’ feedback. Methodology My review is researching 30 articles in the period of: (2019 - 2025). Reflecting on the current literature and shopping trends over the last five years, this paper reveals that digital innovation like automation through Artificial Intelligence, blockchain technology, and personalized marketing for a customer have minimized the breach of trust and have encouraged long-term customer relationships. The results imply that, apart from trust, ethical and consumer-oriented strategies enhance the level of customer loyalty. Last but not the least, this research outlines a roadmap for e-commerce organizations to construct a long-lasting ecosystem that is based on trust and reliability.
Incidence and Seasonal Pattern of Mumps Parotitis in a Paediatric Clinic, Nigeria
Authors: T.G Okari , U.C Onubogu , S.A Tella-Editang 
Published: February 2025

Background: Mumps parotitis, a contagious infection is of public health concern as it can be easily transmitted among cohorts of children in schools, day care centres and religious centres. Although it can be prevented with vaccination, the mumps vaccine is not yet available in the National Immunisation programme in Nigeria.
Aims and Objective: The aim of the study is to determine the incidence of clinically diagnosed mumps parotitis in the Paediatric Outpatient Clinic (POPC) in our health facility and see if there is a seasonal pattern to this infection in our locality.
Methods: A five-year retrospective study evaluated all clinical diagnosis of mumps parotitis obtained from the medical records of the POPC of the Rivers State University Teaching Hospital. Information obtained were the demographic characteristics of the children including date of making the diagnosis and data analyzed with SPSS version 23.
Results: A total of 33,872 patients attended the POPC during the study period. The incidence of clinical mumps parotitis was 3/1000 study population. The infection was more prevalent among males (60.2%) than females and also among under five children (57.1%). The three highest incidence rates occurred in February, March and April and a four-fold increase in annual incidence in 2022.
Conclusion: The incidence of mumps parotitis in this study although low, is more prevalent among under five children and the early parts of the year. This incidence can be further reduced by vaccinating under five children with the mumps vaccine in Nigeria.
How do visual status and age impact on driving performance as measured on a closed circuit driving track?
Authors: Wood Joanne M. 
Published: July 2002

SummaryThe aim of this study was to determine the effects of age and visual impairment on driving performance as measured on a closed circuit course. Sixty two subjects were tested, including young (<30 years) visual normals, old (>60 years) visual normals and old (>60 years) subjects with early visual impairment. All subjects had a binocular visual acuity of 6/12 or better and were legally eligible to drive in Australia. Driving performance was assessed for sign detection and recognition, driving reaction times, speed estimation, and driving time.Age and early visual impairment had significant (P<0.05) effects on sign detection and recognition, peripheral reaction times and driving time. This is of significance because all of the drivers drove regularly and were legally eligible to do so. The results also demonstrate that high contrast visual acuity is a poor predictor of the driving performance skills measured for this range of licensed drivers.
SUB‐CLINICAL PERIPHERAL NERVE INVOLVEMENT IN PSORIATIC ARTHRITIS
Authors: Di Girolamo C. , Massini R. , Lullo F. , Crisci C. 
Published: July 2002

Immunological studies document the role of HLA in psoriasis and the correlation between neuropeptides, psoriasis, and related arthritis. Some anecdotal case reports, moreover, describe a noncasual association between peripheral neuropathy and psoriatic manifestations. To verify a possible subclinical peripheral nerve involvement in this disimmune pathology, we started a pilot study in twenty patients with psoriatic arthritis and in whom other common causes of peripheral neuropathies had been ruled out.We performed a complete clinical neurological examination and a neurophysiological examination (orthodromic sensory and motor nerve conduction velocity in median and tibial nerves; antidromic sensory nerve conduction velocity in sural nerve).In 40% of the patients there was a mild but definite “glove‐stocking” hypoesthesia, while hypopallesthesia was detected in only 20%. Electrophysiologic examinations were less informative borderline distal conduction velocities in 30% of patients.These preliminary data suggest a peripheral nerve involvement in this pathology, mainly affecting the small nerve fibres.
A NOVEL MYELIN PROTEIN ZERO MUTATION ASSOCIATED WITH CHARCOT‐MARIE‐TOOTH TYPE II DISEASE
Authors: D.  , P.  , F.  , L.  , F.  , P.  , E.  
Published: July 2002

Charcot‐Marie‐Tooth type II disease (CMT2) is a typical peroneal muscular atrophy syndrome and is characterised by normal or slightly reduced nerve conduction velocities with signs of axonal degeneration. CMT2 is genetically heterogeneous: linkage to 1p35–p36 (CMT2A; KIF1B gene), 3q13–q22 (CMT2B), 7p14 (CMT2D) and 8p21 (CMT2E; NF‐L gene) loci has been reported for the autosomal dominant disease; however, the majority of CMT2 families do not link to any of the reported loci. Mutations of the myelin protein zero (MPZ) gene were found associated with demyelinating forms of hereditary neuropathies such as CMT1B, Dejerine‐Sottas syndrome and congenital hypomyelination. So far, few CMT2 cases (CMT2F) were found to be caused by point mutations in the MPZ (see CMT Mutation Database, http://molgen‐www.uia.ac.be/CMTMutations/) in 1q22 region.We report a family in which three members are affected with a late‐onset peripheral neuropathy. The index patient is a 68‐year‐old male who presents with pronounced distal muscle weakness of inferior limbs, bilateral pes cavus and absence of deep tendon reflexes. Electrophysiological findings were suggestive of an axonal form of peripheral neuropathy, thus allowing the diagnosis of CMT type 2. At the clinical and electrophysiological examination, two other family members (first cousins of the proband) resulted to be affected. MPZ gene direct sequencing revealed a heterozygous T/A transversion in the exon 3 of the gene, predicting an Asp103Glu aminoacid substitution in the extracellular domain of the protein. This variant was not found in unaffected relatives and in 100 normal chromosomes. This finding confirms the role of protein zero in axonal neuropathies and the phenotypic heterogeneity associated with MPZ mutations.(The laboratory is a member of the European CMT Consortium; partially granted by Ministero della Sanitá to PM, MURST to FA)