bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Fertility Intention and Influencing Factors of Urban Women of Childbearing Age in Liaoning Province under the “Three-child” Policy
Authors: Yuan Cheng , López-Carr David 
Published: August 2023

Abstract
Background:
In the context of implementing the "Three-Child" policy and promoting urban-rural integration, has the fertility intentions of women of childbearing age in Liaoning Province changed? What are the main influencing factors impacting their fertility choices? Are there more people who "don't want to have children" or "are afraid to have children"? Under the multiple push and pull forces of policy intervention, cultural change, and rational choice, which side are their fertility intentions more inclined towards?
Methods:
Through a sample survey of 1,104 urban women of childbearing age in four cities in Liaoning province (Shenyang, Dalian, Fuxin, and Fushun), the fertility intentions and influencing factors of this group were statistically described using cross-tabulation and multiple regression models, and in-depth interviews were conducted with 24 typical cases.
Results:
About 10% of urban women of childbearing age shifted from "never considering having a third child" to "considering having a third child"; less than 10% of urban women of childbearing age explicitly stated "they would definitely have a third child"; more than 70% of urban women of childbearing age explicitly stated, "they would not consider having a third child". The factors that significantly influence fertility intentions are subjective, such as the level of concern regarding children’s impact on freedom and quality of life, opinion of three child policy, and level of traditional values regarding childbirth; the less obvious factors are objective, such as average monthly income, years of education, migration experience.
Conclusions:
First, the number intentions from strong to weak, are 2 children, 1 child, and 3 children. Second, the gender intention from strong to weak is: having both a boy and a girl, only a boy, and only a girl. Third, in terms of the combination of quantity and gender, the intention from strong to weak is 1 boy and 1 girl, 1 boy, and 2 girls, …and 0 girl and 3 boys. Fourth, in terms of the length of the birth interval, the intention from strong to weak is 3 to 4 years, 5 to 6 years, 1 to 2 years, and over 6 years.
Research on the Synergistic Effect of Urbanization and the Ecological Environment in City Clusters: A Case Study of the Chengdu-Chongqing City Cluster Based on the Haken Model
Authors: Wu Weilong , Huang Ying , Zhang Yuzhou , Zhou Bo 
Published: August 2023

Abstract
The development of urbanization and the protection of the ecological environment are important aspects of sustainable development in city clusters, and their coordination and synergy are crucial to achieve this. Regarding the relationship between urbanization and the ecological environment, scholars both in China and internationally have conducted extensive research from the perspective of coordinated development. However, there is a lack of research on the synergistic effects of urbanization and the ecological environment. Taking the Chengdu-Chongqing city cluster as an example, this study uses the Haken model to analyze the synergistic evolution mechanism, development patterns, and future trends of urbanization and the ecological environment. This study draws the following conclusions: (1) while a synergistic development mechanism has been established between urbanization and the ecological environment, the current system is still in a stage of low-level synergy, and the control system’s parameter for the direction and path of evolution is urbanization. (2) From 2001 to 2020, the level of synergistic development between urbanization and the ecological environment was relatively low, mainly moving from low-level synergy to medium-low-level synergy to medium-level synergy. (3) There is a significant spatial disparity in the levels of synergistic development, for which the leading region centers on Chengdu and Chongqing in the northwest and southeast, respectively, and the lagging region comprises the eastern part of the city cluster, mainly represented by Dazhou, Kaizhou, and Yunyang. (4) The future trend of synergistic development between urbanization and the ecological environment in the Chengdu-Chongqing city cluster is promising but requires increased infrastructure construction in mountainous urban areas, enhanced cooperation and circulation in transportation, logistics, information and other aspects, and balanced improvements in the level of synergistic development between urbanization and the ecological environment. The study of the synergistic development effect of urbanization and the ecological environment in city clusters is of great significance for reducing the negative impact of urbanization on the ecological environment, increasing the positive interaction between the two, and promoting sustainable development in city clusters.
An Ensemble Clustering Approach for Modeling Hidden Categorization Perspectives for Cloud Workloads
Authors: Daraghmeh Mustafa , Agarwal Anjali , Jararweh Yaser 
Published: August 2023

Abstract
Effectively managing cloud resources is a complex task due to the interdependencies of various cloud-hosted services and applications. This task is integral to workload categorization, which groups similar cloud workloads to inform workload scheduling and resource management procedures. Although traditional clustering algorithms can categorize workloads into single data grouping patterns, the multifaceted nature of cloud workloads may conceal multiple valid categorization perspectives, indicating a need for a more adaptable clustering approach. This paper presents a novel ensemble clustering approach to enhance the scheduling workload categorization process in cloud computing. Our approach combines various normalization and transformation techniques, including principal component analysis, to form multiple data preprocessing pipelines. The data derived from these pipelines then serve as input for multiple base clustering learners. A novel combined score based on the Silhouette score, Calinski-Harabasz index, and Davies-Bouldin index is then employed to select the optimal models and preprocessing setups. The clustering outcomes of these models are encoded and inputted into a meta-clustering algorithm, effectively capturing complex categorization perspectives. Evaluation of this approach using real-world workload trace data from Microsoft Azure significantly enhances workload segmentation efficacy, thereby improving resource management and quality of service in cloud data centers. This method offers a promising pathway toward improved workload clustering in cloud computing, demonstrating the practical utility of advanced ensemble clustering techniques.
The Effects of Organic Selenium supplementation on Immunity, Physico- biochemical properties of Spermatozoa, and Carcass traits in Male Turkeys
Authors: Biswas Avishek , Deo Chandra , Sharma Divya , Nampalle Mukesh T , Tiwari A. K. 
Published: August 2023

Abstract
The effects of dietary organic selenium (Se) on immunological function, the physical and biochemical properties of sperm, and fertility in male turkey birds were investigated in this study.
The source of organic selenium used was seleno-methionine (Se-M). 160 male turkeys (16 weeks old; 3.2 kg on average weight) were chosen at random, and 20 groups of 8 chicks each were created (4 dietary treatments x 5 replicates). The four experimental diets (T1, T2, T3, and T4) were formulated with addition of 0, 0.3, 0.4, and 0.6 mg Se/kg diet, respectively. The birds were kept in individual cages under standard husbandry conditions for duration of 24 weeks, were fed a breeder's ration, and received ad libitum water. At 28 weeks, antibody tires (humoral immunity) were significantly (P≤0.05) increased, whereas the response to intradermally injected phyto-haemagglutinin (during week 29), an index of the in vivo cell-mediated immune response, was shown to be increased in the groups fed Se-M at 0.4 and 0.6 mg Se-M/kg diet (T3 and T4 group). In birds fed 0.6 mg Se-M/kg (T4), the bursa of Fabricius and the thymus had higher relative weights. Physical characteristics such as sperm volume, sperm concentration, sperm motility, and percentage live sperm were significantly higher (P≤0.05) in the T3 group, whereas the proportion of abnormal and dead spermatozoa was significantly lower (P≤0.05) and fertility was higher in the T3 (0.4 mg Se-M /kg). The amount of total protein and testosterone concentrations were significantly (P≤0.05) higher in the T3 group, but sperm creatinine, acid phosphatase (ACP), and alkaline phosphatase (ALP) concentrations did not differ significantly (P≤0.05). However, thio-barbituric acid reactive substance (TBARS), total antioxidant capacity (TAC) and glutathione peroxidase (GSH-Px) concentration were significantly (P≤0.05) higher in T3 group. Thus, it could be concluded that the basal diet with 0.4 mg/kg organic selenium (seleno-methionine) may be beneficial for physical and biochemical characteristics of semen, improved the immunity and fertility in adult male turkeys.
Factors associated with acute postoperative pain in preschool children in a referral clinic in eastern Colombia
Authors: Lizcano Dairon Jose Gelvez , Melendez Hector Julio , Wilches Hector Hugo Torres , Gallardo Paula Andrea Durán , Medina Jhoan S. Hurtado , Santamaría Andrés Felipe Mantilla , Moreno Marlon Jesús Lozano 
Published: August 2023

Abstract
Purpose
Pain is one of the most difficult variables to quantify in the pediatric population, besides being the most determinant parameter of the length of stay in a post-anesthetic recovery room. The aim of this study is to characterize the most determinant variables in postoperative pain in our pediatric population.
Methods
An observational cross-sectional study was conducted in preschoolers and school children operated at Clínica Materno Infantil San Luis in Bucaramanga, between January and June 2018. Postoperative pain was evaluated and characterized using the LLANTO pain scale in addition to other related variables.
Results
Postoperative pain prevalence was 65.6%. Propofol and fentanyl were identified as protective factors to prevent postoperative pain with a RR of 0.55 and 0.44, respectively. The urology and laparotomy surgical groups were associated with less postoperative pain with a RR of 0.63 and 0.6, respectively.
Conclusion
Propofol and fentanyl use was identified as the most important protective factor for postoperative pain. In addition, there is a close relationship between anxiety and postoperative pain. According to the surgery type, it is suggested to use different adjusted anesthetic methods for each case.
Clinical Response to a PARP Inhibitor and Chemotherapy in a Child with BARD1-Mutated Refractory Neuroblastoma: A Case Report
Authors: Federico Sara , Cupit-Link Margaret , Hagiwara Kohei , Zhang Jinghui 
Published: August 2023

Abstract
Despite advances in the treatment of high-risk neuroblastoma, approximately half of these patients die from the disease. Targeted therapy based on synthetic lethality associated with homologous recombination deficiency (HRD) caused by germline mutations in homologous recombination repair genes has shown great efficacy in several adult solid tumors. Here we report the first successful treatment of a pediatric patient with refractory neuroblastoma and a germline pathogenic mutation in BARD1 using a PARP inhibitor, talazoparib, in combination with cytotoxic chemotherapy and radiation therapy. Allele-specific expression in RNA-seq indicates bi-allelic loss of BARD1 in tumor; however, the HRD score was below the threshold currently used for HRD classification in adult cancers. Our study demonstrates that the use of PARP inhibition in combination with DNA-damaging agents should be considered in children with BARD1-mutated neuroblastoma and cautions against the use of HRD score alone as a biomarker for this pediatric population.
The association between Angina and Triglyceride-Glucose Index among non-Diabetic Patients: A NHANES Cross-Sectional study: 2001-2020
Authors: Sawaf Bisher , Swed Sarya , Bohsas Haidara , Alibrahim Hidar , Nasif Mohamad Nour , Ali Eman , Hafez Wael , Hennawi Hussam Al , Tashrifwala Fatema Ali Asgar , Khan Ubaid , Al-Rassas Safwan , Hussain Noor , Zaidi Abdul Rehman Zia , Alghalyini Baraa , Mohamed Waleed Farouk , Othman Mohammed Abdelmoneim M. , Farwati Amr , Seijari Mohammed Najdat , Battikh Naim , Robles-Velasco Karla , Cherrez-Ojeda Ivan 
Published: August 2023

Abstract
Background
A current alternative test of insulin resistance that has been considered a predictor of metabolic syndrome and cardiovascular disease (CVD) is the triglyceride-glucose (TyG) index. However, it is unknown if the TyG index may estimate the risk and incidence of angina in the non-diabetic population. This research examines the correlation between the TyG index and angina in non-diabetic individuals.
Methods
Data from the National Health and Nutrition Examination Survey (NHANES) were used in this study from 2001 to 2020; non-diabetic individuals aged 18 years or older were our targeted sample. We divided the sample regarding the angina as follows: no angina, no exertional chest pain, possible angina, and definitive angina. As well, the categories of TyG index were < = 8.22, 8.23–8.60, 8.61–9.01, and 9.02+. The analysis was conducted using a 4-year weight at fasting (WTSAF4YR) according to NHANES analysis criteria. The receiver operating characteristic (ROC) analysis was utilized to determine the sensitivity and specificity of the TyG index for estimating the endpoints of interest (angina). Univariate and multivariate logistic regression were performed to determine the factors correlated with the study outcomes, and the analysis was performed using IBM, SPSS Version 28.0.
Results
We involved 6,762 non-diabetic individuals, including 49 individuals who had possible angina, and 487 individuals had definitive angina, in addition 1,690 individuals with TyG above 9.02. We addressed a statistically difference between TyG and gender, as 55.9% of participants with high TyG (> 9.02) were males. The Pearson chi-square test showed no statistically significant difference between angina subgroups and TyG index categories, p-value: 0.065. In addition, six regression models confirmed that higher values of TyG index were not associated with the presence of no exertional chest pain, definitive angina, or possible angina. In addition, the TYG test had low diagnostic accuracy for identifying patients with angina (Sensitivity: 52.8%, Specificity: 52.83% AUC; 52.82%, P-value < 0.05).
Conclusion
The TyG index cannot be utilized as an alternate predictive marker for angina in the non-diabetic population since it has no correlation to angina risk factors.
Psychological Distress and Stressor: A Community Based Study of Nepali Migrant Returnees
Authors: Acharya Khagendra , Kharel Arjun 
Published: August 2023

Abstract
The massive outflow of Nepali people as a part of their living strategy is a quite recent phenomenon; scholars have often associated such migration either with the internal conflict that started in 1996 or global economic liberalization towards the end of the century. It was in this decade the six countries of the Gulf Cooperation Council (GCC) and Malaysia became major destinations for migrant workers. Given the nature of acute adversities that Nepali migrant workers like those moving out from developing countries to the developed ones face in these countries, they are often reported to experience distress. This study, through sequential explanatory mixed method, examined the psychological distress of Nepali migrant returnees from nine destinations, namely Malaysia, Qatar, Kuwait, Saudi Arabia, the United Arab Emirates, Oman, Bahrain, Israel and Jordan. Mental health issue was found to prevail among 28.3% returnees. Work related factors – type of visa used to go abroad, income from work, and the nature of return – was observed to have significant association (p < 0.05) with bad mental health status. From the analysis of qualitative data, the themes related to pre-departure, during work, and after the return stressors were identified.
Controlled Large-Area Lithium Deposition to Reduce Swelling of High-Energy Lithium Metal Pouch Cells in Liquid Electrolytes
Authors: Xiao Jie , Liu Dianying , Wu Bingbin , Xu Yaobin , Ellis Jacob , Baranovski Arthur , Lu Dongping , Lochala Joshua , Anderson Cassidy , Baar Kevin , Qu Deyang , Yang Jihui , Aranda Diego , Lopez Katherine , Balbuena Perla , Seminario Jorge , Liu Jun 
Published: August 2023

Abstract
Lithium (Li) metal battery technology has attracted world-wide attention because of its high energy density, but its practical application is hindered by several challenges, with one significant issue being the large volume change and cell swelling. While external pressure is known to have a profound effect on cell performance, there are currently no reports exploring the relationship between external pressure and the electroplating of Li+ in large-format pouch cells to enhance overall performance. Here we investigate the influence of externally applied pressure on the electroplating and stripping of lithium metal in 350 Wh/kg pouch cells. A hybrid constant gap and constant pressure design is designed to apply a minimal external pressure for practical application. The self-generated pressures are monitored and quantified which are further correlated to the observed charge-discharge processes. A two-stage cycling process is observed. In the first stage, Li+ ions utilized are mainly supplied by the cathode which shuttle between the cathode and anode with minimal Li loss which minimizes cell swelling but only happens when pressure is applied appropriately. In the second stage, Li from the Li foil anode participates in the reaction and the thickness of the anode gradually increases. However, even after extensive cycling, cell swelling remains less than 10%, comparable to that of state-of-the-art Li-ion batteries. In addition, the pressure distribution along the horizontal direction across the surface of Li metal pouch cell reveals a complex behavior of Li+ migration during the electroplating (charge) process. The external pressure encourages a preferred plating process of Li in the central region, necessitating the development of new strategies to address uneven Li plating and utilization to advance Li metal battery technology.
The Trail Making Test Part B as a Preclinical Indicator of Alzheimer's Disease and Proxy for Spatial Navigation
Authors: Nevers Jennifer I 
Published: August 2023

Abstract
Background: Preclinical Alzheimer's disease (AD) may create unrecognized risks for physical injury and death due reduction of acetylcholine and disease presence in brain areas involved with spatial navigation (SN). Possible preclinical changes in SN, such as driving, might be indicated by performance on the Trails Making Test Part B (TMT-B). This neuropsychiatric test has time to completion scores associated with at-risk driving ability.
Methods: Linear mixed-effects were performed on TMT-B spanning 1 to 15 years of data on cognitively normal (pre-AD) individuals who later developed AD dementia and compared to those who did not develop the disease (non-AD. Effect size analysis was performed on individual annual time points.
Results: 1104 pre-AD and 14,663 non-AD participants were included ed from the National Alzheimer's Coordinating Center. The pre-AD individuals demonstrated scores associated with at-risk driving. The pre-AD group increased by 3.498 seconds per year, p <.001, whereas the non-AD group increased by 1.845 seconds, p <.001. Effect size range: Cohens d = .217 to .631. Pre-Ad females increased by 3.695 seconds per year, p <.001, .843 p <.001. Effect size range: Cohens d =.383 to .692. Pre-AD males increased by 3.189 seconds per year, p <.001, compared to non-AD males increase of 1.890 seconds, p <.001, with effect size range of Cohens d = 0.259 to 0.520.
Conclusion: The TMT-B may serve as a preclinical screening instrument in longitudinal studies, inform further inquiry for SN risks in this population and correlation with changes in brain acetylcholine levels
A Hybrid GNN Model for Fake News Detection in Digital Media
Authors: B Sathyanarayana K , Ahmed Shoieb , Pradeep H K 
Published: August 2023

Abstract
Newsflash intake from shared mass media is becoming progressively admired now. Public media brings benefits to subscribers precisely to the underlying nature of speedy spreading, inexpensive, and affluent access. In our work, we describe a strong system for recognizing false news summary in the Digital Media that utilizes valuable Graphical based model with Neural Networks. Simulated news is created moreover among rumourmongers or else in the administrative subjects, hence for the undertaking of trailing we have handled dual types of datasets within our methodology. They really are Politifact which contains data related to politics and Gossipicop that contains data related to gossipmongers. We have compiled 5464 samples of Gossipicop compared to 314 samples of Politifact as a greater number of rumourmongers are forged. Three-level Approach is proposed where GCNFN is implemented using two GCN layers and one mean-pooling layer as the graph encoder. The 320-dimensional node feature is composed of 300-dimensional comment word2vec embedding along with 20-dimensional profile features. As the graph coding the GNN-CL is implemented using DiffPool along with profile feature as the node feature. Anticipated Method is judge against the latest work and have established a higher level effectiveness of 94.9% with Ten-Fold verification.
Immunological assessment of recent immunotherapy for colorectal cancer.
Authors: Das Subhadeep , Acharya Diptikanta 
Published: August 2023

Abstract
Colorectal cancer (CRC) is the third most prevalent malignancy with increased incidence and mortality rates worldwide. Traditional treatment approaches have attempted to efficiently target CRC; however, they have failed in most cases owing to the cytotoxicity and non-specificity of these therapies. Therefore, it is essential to develop an effective alternative therapy to improve the clinical outcomes in heterogeneous CRC. Immunotherapy has transformed cancer treatment with remarkable efficacy and overcomes the limitations of traditional treatments. With an understanding of the cancer-immunity cycle and tumor microenvironment evolution, current immunotherapy approaches have elicited enhanced antitumor immune responses. In this comprehensive review, we outline the latest advances in immunotherapy targeting CRC and provide insights into the antitumor immune responses reported in landmark clinical studies. We focused on highlighting the combination approaches to achieve synergistic immune responses and eliminate immunosuppression. This review aimed to understand the limitations and potential of recent immunotherapy clinical studies conducted in the last five years (2019–2023) and to transform this knowledge into a rational design of clinical trials intended for effective antitumor immune responses in CRC.