bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic synthesis of expert opinion on effective policies to tackle bacterial resistance worldwide
Authors: Mostafaei Ali , Akbari Hamid , Lundborg Cecilia Stålsby , Kabiri Neda , Vahed Nafiseh , Hajebrahimi Sakineh , Doshmangir Leila 
Published: March 2023

AbstractActions that are taken to preserve effective antibacterial agents and eliminate transmission of resistant organisms are crucial to prevent a catastrophic postantibiotic era. In this systematic review, we searched and appraised relevant texts and expert opinions to determine effective strategies to tackle bacterial resistance worldwide. We considered expert opinions, consensus, current discourses, comments, assumptions or assertions and discussion papers published in English. We searched following databases for expert opinion‐based literature: MEDLINE, CINAHL, ISI Web of Knowledge, SCOPUS, Cochrane Central Register of Controlled Trials and World Health Organization (WHO). We extracted the textual data from texts using a standardised data extraction tool. Textual pooling was not possible, so the conclusions were presented in a narrative form. Eighteen texts were included in this review. The findings show that, the most repeated policies and strategies include implementing and strengthening bacterial resistance surveillance, developing national guidelines, improving public awareness; enhancing home and everyday life hygiene; improving prescribing patterns, improving laboratories capacity, promoting innovation and research in new drugs and technology and strengthening coordination. This review systematically gathered strategies that were recommended by textual publications. To our knowledge, this was the first systematic review of text and opinion in the field of bacterial resistance. These results can be used by policymakers, hospital managers, and governments, alongside the results of quantitative and qualitative systematic reviews.
Constraints on the doublet left-right symmetric model from Higgs data
Authors: Karmakar Siddhartha , More Jai , Pradhan Akhila Kumar , Sankar S. Uma 
Published: March 2023

Abstract
We study the constraints on the doublet left-right symmetric model (DLRSM) arising due to the Higgs data. The SU(2)L symmetry of this model is broken by three vacuum expectation values, κ1, κ2 and vL. Most studies of this model assume that the ratios r = κ2/κ1 and w = vL/κ1 are very small. In this work, we study the constraints imposed on r and w by the Higgs data from LHC. We consider the most general scalar potential and calculate the masses of the CP-even scalars and the couplings of the lightest of these scalars to itself, to W and Z gauge bosons and to the third generation quarks. We find that there is no lower bound on either r or w. Equating the mass of the lightest CP-even scalar to 125 GeV leads to an upper limit w < 6.7. The requirement that the Yukawa coupling of the quarks to the Higgs bidoublet of the model should be perturbative yields the upper bounds r < 0.8 and w < 3.5. The Yukawa coupling of the bottom quark to the lightest CP-even scalar strongly disfavours value of r, w < 0.1 and shows a marked preference for values of w ∼ $$ \mathcal{O} $$
O
(1).
Temperature alters the inotropic, chronotropic and proarrhythmic effects of histamine in atrial muscle preparations from humans and H2-receptor overexpressing mice
Authors: Hoffmann Robert J. R. , Gergs Ulrich , Hofmann Britt , Kirchhefer Uwe , Neumann Joachim 
Published: March 2023

AbstractWe investigated whether hypothermia and hyperthermia can alter the efficacy and potency of histamine at increasing the force of cardiac contractions in mice that overexpress the human H2 receptor only in their cardiac myocytes (labelled H2-TG). Contractile studies were performed in an organ bath on isolated, electrically driven (1 Hz) left atrial preparations and spontaneously beating right atrial preparations from H2-TG mice and wild-type (WT) littermate control mice. The basal beating rate in the right atrial preparations from H2-TG mice was lowered by hypothermia (23 °C) and elevated by hyperthermia (42 °C). Furthermore, the efficacy of histamine (0.01–100 µM) at exerting positive inotropic effects was more severely attenuated in the left and right H2-TG mouse atria under hypothermia and hyperthermia than under normothermia (37 °C). Similarly, the inotropic response to histamine was attenuated under hypothermia and hyperthermia in isolated electrically stimulated (1 Hz) right atrial preparations obtained from humans undergoing cardiac surgery. The phosphorylation state of phospholamban at serine 16 at 23 °C was inferior to that at 37 °C in left atrial preparations from H2-TG mice in the presence of 10 µM histamine. In contrast, in human atrial preparations, the phosphorylation state of phospholamban at serine 16 in the presence of 100 µM histamine was lower at 42 °C than at 37 °C. Finally, under hyperthermia, we recorded more and longer lasting arrhythmias in right atrial preparations from H2-TG mice than in those from WT mice. We conclude that the inotropic effects of histamine in H2-TG mice and in human atrial preparations, as well as the chronotropic effects of histamine in H2-TG mice, are temperature dependent. Furthermore, we observed that, even without stimulation of the H2 receptors by exogenous agonists, temperature elevation can increase arrhythmias in isolated right atrial preparations from H2-TG mice. We propose that H2 receptors play a role in hyperthermia-induced supraventricular arrhythmias in human patients.
Morphological and behavioral analysis of Slc35f1-deficient mice revealed no neurodevelopmental phenotype
Authors: Ehlers Julia Sophie , Bracke Katharina , von Bohlen und Halbach Viola , Siegerist Florian , Endlich Nicole , von Bohlen und Halbach Oliver 
Published: March 2023

AbstractSLC35F1 is a member of the sugar-like carrier (SLC) superfamily that is expressed in the mammalian brain. Malfunction of SLC35F1 in humans is associated with neurodevelopmental disorders. To get insight into the possible roles of Slc35f1 in the brain, we generated Slc35f1-deficient mice. The Slc35f1-deficient mice are viable and survive into adulthood, which allowed examining adult Slc35f1-deficient mice on the anatomical as well as behavioral level. In humans, mutation in the SLC35F1 gene can induce a Rett syndrome-like phenotype accompanied by intellectual disability (Fede et al. Am J Med Genet A 185:2238–2240, 2021). The Slc35f1-deficient mice, however, display only a very mild phenotype and no obvious deficits in learning and memory as, e.g., monitored with the novel object recognition test or the Morris water maze test. Moreover, neuroanatomical parameters of neuronal plasticity (as dendritic spines and adult hippocampal neurogenesis) are also unaltered. Thus, Slc35f1-deficient mice display no major alterations that resemble a neurodevelopmental phenotype.
Approaches to X-ray CT Evaluation of In-Situ Experiments on Damage Evolution in an Interpenetrating Metal-Ceramic Composite with Residual Porosity
Authors: Schukraft Joél , Lohr Christoph , Weidenmann Kay André 
Published: March 2023

AbstractAn interpenetrating metal-ceramic composite of AlSi10Mg and an open porous alumina foam, with residual porosity is investigated for the material damage under compressive load within an X-ray CT in-situ load stage. The focus of the research is on damage detection and evaluation with the commercial Avizo® software by ThermoFisher Scientific. Four different approaches are used to detect the material damage and compared afterward on their efficiency in detecting the material damage volume but not the porosity within the material. Image Stack Processing combined with different filtering techniques, as well as Digital Volume Correlation is used in this work to separate the material porosity and the material damage. For the here investigated material system with mainly spherical pores, a geometrical filter was very successful to separate porosity and damage. Nevertheless, the Digital Volume Correlation based approach showed many advantages in damage detection and turned out to be the approach of choice regarding damage onset.
Personalised Learning through Context-Based Adaptation in the Serious Games with Gating Mechanism
Authors: Shum Lok Cheung , Rosunally Yasmine , Scarle Simon , Munir Kamran 
Published: March 2023

AbstractWhen the traditional "one size fits all" approach is used in designing educational games, the game context is usually arranged in a fixed sequence. However, the designated content may not effectively support the diversity of players. The player's ability and characteristics should be considered and supported with an appropriate learning context embedded in the game to facilitate personalised experiences. Adapting game scenarios to a player's characteristics can boost motivation and ultimately improve learning outcomes. This research applies a context-aware design approach and the Learner-Centered Design approach to establish a personalised adaptation framework for designing educational serious games and enhancing personalised knowledge delivery. The proposed framework decouples the game logic implementation and adaptation mechanism. It dynamically adapts the designed game objects and activities to personal learning objectives, learning levels and learning progress to achieve a non-linear learning sequence. Through synchronous real-time xAPI message exchange mechanisms, system components and learning content adaptation are enabled. The adaptation aims to fit personal learning objectives and provide a non-linear learning sequence in a game environment. The framework provides students with personalised learning experiences. A game named GhostCoder is implemented and used to evaluate the framework. Based on the externalised adaptive mechanism, the game content is adapted to the player's performance by adjusting the difficulty of the learning content within the game. Testing of the game in the lab environment has been performed. At the next stage, an evaluation will be conducted with the target groups of students.
Intermolecular And Dynamic Investigation of The Mechanism of Action of Reldesemtiv on Fast Skeletal Muscle Troponin Complex Toward the Treatment of Impaired Muscle Function
Authors: Issahaku Abdul Rashid , Ibrahim Mahmoud A. A. , Mukelabai Namutula , Soliman Mahmoud E. S. 
Published: March 2023

AbstractMuscle weakness as a secondary feature of attenuated neuronal input often leads to disability and sometimes death in patients with neurogenic neuromuscular diseases. These impaired muscle function has been observed in several diseases including amyotrophic lateral sclerosis, Charcot–Marie–Tooth, spinal muscular atrophy and Myasthenia gravis. This has spurred the search for small molecules which could activate fast skeletal muscle troponin complex as a means to increase muscle strength. Discovered small molecules have however been punctuated by off-target and side effects leading to the development of the second-generation small molecule, Reldesemtiv. In this study, we investigated the impact of Reldesemtiv binding to the fast skeletal troponin complex and the molecular determinants that condition the therapeutic prowess of Redesemtiv through computational techniques. It was revealed that Reldesemtiv binding possibly potentiates troponin C compacting characterized by reduced exposure to solvent molecules which could favor the slow release of calcium ions and the resultant sensitization of the subunit to calcium. These conformational changes were underscored by conventional and carbon hydrogen bonds, pi-alkyl, pi-sulfur and halogen interactions between Reldesemtiv the binding site residues. Arg113 (−3.96 kcal/mol), Met116 (−2.23 kcal/mol), Val114 (−1.28 kcal/mol) and Met121 (−0.63 kcal/mol) of the switch region of the inhibitory subunit were among the residues that contributed the most to the total free binding energy of Reldesemtiv highlighting their importance. These findings present useful insights which could lay the foundation for the development of fast skeletal muscle small molecule activators with high specificity and potency.
Substitution benefits of British Columbia’s mitigation strategies in the bioeconomy
Authors: Xie Sheng H. , Kurz Werner A. , McFarlane Paul N. 
Published: March 2023

AbstractGlobally, efforts to increase land sector contributions to net-zero emissions are pursued. Harvested wood products may retain carbon, and substitute emission-intensive products. The emission reductions achieved through substitution, or substitution benefits, can inform the design of climate-effective wood-use strategies. Mitigation analyses of a wood-based bioeconomy therefore need to include substitution to evaluate the mitigation outcomes across sectors. Substitution benefits can be estimated using displacement factors, which quantify the emissions avoided per unit of wood use. Here, we calculated the displacement factors of timber constructions and wood-derived biofuels to be around 1.03 and 0.45 tCO2e/tCO2e, respectively. Assuming substitution was achieved when changes in human behavior increased the share of wood use relative to the reference market share, we added the substitution benefits to a previous analysis that focused on biogenic emissions in British Columbia, Canada. At projected declining harvest rates, the theoretical maximum reduction that forest products can contribute over the period 2016 to 2050 is 66 MtCO2e·year−1 with an uncertainty range of 45–79 MtCO2e·year−1, relative to the baseline, by focusing on long-lived, high-displacement construction applications. However, because construction uses of wood in foreign markets are not guaranteed, and constrained by market access, the practical strategy that combines construction and biofuel uses can achieve 17.4 MtCO2e·year−1, equivalent to 30% of British Columbia’s 2050 target. Although a transformation of the bioeconomy may help achieve both climate and socio-economic benefits, potential conflict exists between maximizing regional and global benefits. How and where wood will be used can influence the desired mitigation outcomes.
Designing innovative digital platforms from both human and nonhuman perspectives
Authors: Kimura Risa , Nakajima Tatsuo 
Published: March 2023

AbstractDigital platforms are becoming critical infrastructures for supporting a variety of innovative services that enhance our everyday lives. These platforms need to offer not only rational services but also ludic or slow services that focus on human pleasure. One important aspect of creating innovative digital platforms is that their concrete requirements and potential opportunities are vague before they are designed. Thus, designing, prototyping and evaluating digital platforms iteratively is essential for refining or customizing them, as knowledge is gradually gained throughout these iterations. However, it is costly to develop prototype platforms and evaluate them with traditional methods. A better tool that can be used to reveal these platforms’ potential opportunities by conceiving them in a simple and rapid way is needed. In this paper, we present our journey to develop nine digital platforms that share collective human sight and hearing with the Human-Material-Pleasure (HMP) annotation method, which is a tool that we use to describe the visually structured annotations of multiple digital platforms based on the annotated portfolio method. The most significant part of the paper presents annotated portfolios based on the HMP annotation method for the nine digital platforms that we develop and shows how these annotated portfolios play an essential role in revealing and exploring the potential opportunities of our platforms during the refinement process. We also discuss how the HMP annotation method is used in the context of exploring the potential opportunities of wearable shape-changing robotic devices; these devices have significantly different characteristics from our digital platforms, which allows for showing insights more objectively by extracting diverse insights from an alternative angle.
TGFBR3L is associated with gonadotropin production in non-functioning gonadotroph pituitary neuroendocrine tumours
Authors: Kolnes Anders Jensen , Øystese Kristin Astrid Berland , Sjöstedt Evelina , Olarescu Nicoleta Cristina , Heck Ansgar , Pahnke Jens , Dahlberg Daniel , Berg-Johnsen Jon , Ringstad Geir , Casar-Borota Olivera , Bollerslev Jens , Jørgensen Anders Palmstrøm 
Published: March 2023

Abstract
Purpose
Transforming growth factor-beta receptor 3-like (TGFBR3L) is a pituitary enriched membrane protein selectively detected in gonadotroph cells. TGFBR3L is named after transforming growth factor-beta receptor 3 (TGFBR3), an inhibin A co-receptor in mice, due to sequence identity to the C-terminal region. We aimed to characterize TGFBR3L detection in a well-characterized, prospectively collected cohort of non-functioning pituitary neuroendocrine tumours (NF-PitNETs) and correlate it to clinical data.

Methods
144 patients operated for clinically NF-PitNETs were included. Clinical, radiological and biochemical data were recorded. Immunohistochemical (IHC) staining for FSHβ and LHβ was scored using the immunoreactive score (IRS), TGFBR3L and TGFBR3 were scored by the percentage of positive stained cells.

Results
TGFBR3L staining was selectively present in 52% of gonadotroph tumours. TGFBR3L was associated to IRS of LHβ (median 2 [IQR 0–3] in TGFBR3L negative and median 6 [IQR 3–9] in TGFBR3L positive tumours, p < 0.001), but not to the IRS of FSHβ (p = 0.32). The presence of TGFBR3L was negatively associated with plasma gonadotropin concentrations in males (P-FSH median 5.5 IU/L [IQR 2.9–9.6] and median 3.0 [IQR 1.8–5.6] in TGFBR3L negative and positive tumours respectively, p = 0.008) and P-LH (median 2.8 IU/L [IQR 1.9–3.7] and median 1.8 [IQR 1.1-3.0] in TGFBR3L negative and positive tumours respectively, p = 0.03). TGFBR3 stained positive in 22% (n = 25) of gonadotroph tumours with no correlation to TGFBR3L.

Conclusion
TGFBR3L was selectively detected in half (52%) of gonadotroph NF-PitNETs. The association to LHβ staining and plasma gonadotropins suggests that TGFBR3L may be involved in hormone production in gonadotroph NF-PitNETs.
How do universities’ organizational characteristics, management strategies, and culture influence academic research collaboration? A literature review and research agenda
Authors: Kienast Sarah-Rebecca 
Published: March 2023

AbstractIn the contemporary science and higher education system, national and supranational governments fund and foster universities to collaborate through specific funding lines and competition in World University Rankings, making it indispensable for universities to demonstrate collaboration at the organizational level. Thus, universities strive to encourage their scientific members to collaborate – and to different degrees – facilitate forms of collaboration. Questions on how universities as organizations influence academic research collaboration arise. To go beyond the existing literature, this study firstly develops an analytical two-dimensional framework organizing the literature on four levels of investigation (meta, macro, meso, micro). Based on this framework, the paper presents a literature review of the current state of the art in academic research collaboration. Secondly, the paper establishes a research agenda by synthesizing organizational influences found as organizational characteristics, management strategies, and organizational culture and presents three research avenues for future research. The paper concludes that we have only just begun to study the organizational influences of universities (especially the organizational culture) on academic research collaboration and how these organizational categories are interrelated.
The use of cellular telecommunication towers as nesting sites by pied crows (Corvus albus) in an urban mosaic landscape
Authors: Senoge Ntaki D. , Downs Colleen T. 
Published: March 2023

AbstractCorvids are known for their urban exploitation, often using artificial infrastructure to roost and nest. In many areas of its distribution range, the pied crow (Corvus albus) is often common in areas of anthropogenic land use, often breeding and foraging near human settlements. In this study, we monitored pied crow use of cellular telecommunication towers as nesting sites in Pietermaritzburg, South Africa, during three breeding seasons. We found that of the 36 towers situated across the urban mosaic landscape, pied crows used 17 (47.2%) as nesting sites while 19 were not used. Many towers were used in subsequent years as nesting sites. Overall, 41 pied crow nests on towers in urban mosaic landscapes were counted by the end of the study. Towers had a mean (± SE) distance of 1595.2 ± 151.0 m between them and were located mainly in the suburbs of Edendale and Northdale. As shown by the hotspot analysis and spatial distribution of used and unused towers, it was unclear why some towers were not being used as nesting sites. We assessed the relationship between pied crow nesting sites and land cover features. We found that tower nesting was best explained by cropland (wi = 0.58), forest (wi = 0.94), grassland (wi = 0.66), schools (wi = 0.56) and relief (wi = 0.56). The continued persistence of pied crows in urban mosaic landscapes with natural and /or managed green spaces, the availability of anthropogenic infrastructure and food in these, and their behavioural plasticity will likely increase their numbers in such landscapes.
Dynamical Modelling of the Global Cement Production and Supply System, Assessing Climate Impacts of Different Future Scenarios
Authors: Sverdrup Harald Ulrik , Olafsdottir Anna Hulda 
Published: March 2023

Abstract
The global cement and concrete demand, production, supply, and the general global market price was modelled using the WORLD7 model for different future scenarios. The model was used to analyze some possible measures to reduce the climate impact of cement production. The main result from this study is that three factors may bring regulatory limitations to be imposed on cement production. The contribution of CO2 to the atmosphere, the amount of iron used in construction and the use of energy in production are the main factors that may cause limitations. Cement accounts for about 8% of the global CO2 emissions and energy use at present, and this fraction is projected by the simulations to continue to increase. To reduce CO2 emissions from cement production, ending fossil fuel use for calcination, combined with a change towards using mortar as an alternative for making concrete should be considered. Our conclusion is that the long-term limitation for cement production is the availability of carbon-free energy, and the availability of iron for reinforcement bars. Eliminating the use of hydrocarbons for cement calcination may reduce the future the contribution from cement by 38%. Eliminating the use of hydrocarbons for calcination combined with substituting cement with mortar to 50%, the contribution to the future global average temperature increase is reduced by 62%. Eliminating the use of hydrocarbons for calcination combined with substituting cement with mortar to 90% is a reduction by 90% in the contribution from cement.