bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of predictive model based on deep learning method for classification of dyslipidemia in Chinese medicine
Authors: Liu Jinlei , Dan Wenchao , Liu Xudong , Zhong Xiaoxue , Chen Cheng , He Qingyong , Wang Jie 
Published: April 2023

AbstractBackgroundsDyslipidemia is a prominent risk factor for cardiovascular diseases and one of the primary independent modifiable factors of diabetes and stroke. Statins can significantly improve the prognosis of dyslipidemia, but its side effects cannot be ignored. Traditional Chinese Medicine (TCM) has been used in clinical practice for more than 2000 years in China and has certain traits in treating dyslipidemia with little side effect. Previous research has shown that Mutual Obstruction of Phlegm and Stasis (MOPS) is the most common dyslipidemia type classified in TCM. However, how to compose diagnostic factors in TCM into diagnostic rules relies heavily on the doctor's experience, falling short in standardization and objectiveness. This is a limit for TCM to play its advantages of treating dyslipidemia with MOPS.MethodsIn this study, the syndrome diagnosis in TCM was transformed into the prediction and classification problem in artificial intelligence The deep learning method was employed to build the classification prediction models for dyslipidemia. The models were built and trained with a large amount of multi-centered clinical data on MOPS. The optimal model was screened out by evaluating the performance of prediction models through loss, accuracy, precision, recall, confusion matrix, PR and ROC curve (including AUC).ResultsA total of 20 models were constructed through the deep learning method. All of them performed well in the prediction of dyslipidemia with MOPS. The model-11 is the optimal model. The evaluation indicators of model-11 are as follows: The true positive (TP), false positive (FP), true negative (TN) and false negative (FN) are 51, 15, 129, and 9, respectively. The loss is 0.3241, accuracy is 0.8672, precision is 0.7138, recall is 0.8286, and the AUC is 0.9268. After screening through 89 diagnostic factors of TCM, we identified 36 significant diagnosis factors for dyslipidemia with MOPS. The most outstanding diagnostic factors from the importance were dark purple tongue, slippery pulse and slimy fur, etc.ConclusionsThis study successfully developed a well-performing classification prediction model for dyslipidemia with MOPS, transforming the syndrome diagnosis problem in TCM into a prediction and classification problem in artificial intelligence. Patients with dyslipidemia of MOPS can be accurately recognized through limited information from patients. We also screened out significant diagnostic factors for composing diagnostic rules of dyslipidemia with MOPS. The study is an avant-garde attempt at introducing the deep-learning method into the research of TCM, which provides a useful reference for the extension of deep learning method to other diseases and the construction of disease diagnosis model in TCM, contributing to the standardization and objectiveness of TCM diagnosis.
Source contribution of PCBs and OC/EC at a background site in the Yangtze River Estuary: insight from inter-comparison by Positive Matrix Factorization (PMF)
Authors: Lin Tian , Zhou Wanqing , Zhao Shizhen , Li Minqiao , Guo Zhigang 
Published: April 2023

AbstractBackground air samples, including gas-phase components and suspended particulates, were collected over one year (2013-2014) for an investigation of polychlorinated biphenyls (PCBs) and OC/EC in the Yangtze River Estuary. PCB concentrations exhibited great seasonal variability and ranged between 43 and 720 pg·m−3. They mainly were associated with the gas phase, and levels peaked in the summer time at 327 ± 177 pg·m−3. By contrast, concentrations of particulate PCBs and OC/EC were higher in the cold seasons, which was due to high-temperature combustion emission and frequent haze events. According to the results of a positive matrix factorization, the combustion and non-combustion sources of PCBs accounted for 30% and 70% of total PCBs, respectively. Meanwhile, SOC/OC value was 54.7% ± 20.1%, which suggests gas-to-particle conversion process plays a significant role in contributing to atmospheric particles. To this end, the influence of OC/EC on both combustion and non-combustion PCBs in the long-range atmospheric transport deserves further research.
Graphical Abstract
Migräne – eine multifaktorielle Erkrankung
Authors: Kubat Heike 
Published: April 2023

Was ist zu dem Thema bereits bekannt? Triggerfaktoren werden für eine Migräneattacke verantwortlich gemacht. Individuelle und situationsabhängige Reaktionen auf Trigger sind unterschiedlich. Wie wird eine neue Perspektive eingebracht? Ein adäquater Umgang mit Triggerfaktoren, Prodromal- und Begleitsymptomen ist entscheidend für ein gutes Krankheitsmanagement. Was sind die Auswirkungen auf die Praxis? Statt einer Vermeidung von Triggerfaktoren ist das Entwickeln von Copingstrategien sinnvoll. Anstatt Ängste vor einer nächsten Attacke zu erleben, ist das Einschätzen und Erkennen von Vorboten hilfreich.
The Diurnal Cycle of East Pacific Convection, Moisture, and CYGNSS Wind Speed and Fluxes
Authors: Riley Dellaripa Emily M. , Maloney Eric D. , DeMott Charlotte A. 
Published: April 2023

AbstractThe far eastern tropical Pacific is one of the rainiest locations on Earth. This region is characterized by a robust diurnal cycle with precipitation initiating over the Andes mountains in Colombia in the late afternoon and moving offshore overnight while organizing into mesoscale convective systems (MCSs). As the MCSs move westward, they can seed tropical easterly waves that develop into tropical cyclones. Novel measurements of near‐surface wind speeds and latent heat flux (LHFLX) from the Cyclone Global Navigation Satellite System (CYGNSS) mission and ERA5 reanalysis are used to evaluate changes to regional flow patterns, moisture, and LHFLX that favor a strong westward propagating diurnal cycle of precipitation in this region. Days with strongly versus weakly westward propagating diurnal precipitation are compared during the extended boreal summer of the CYGNSS era (May–October 2018–2021). Strongly propagating days have a more moist lower troposphere with stronger vertically integrated moisture flux convergence than days with weakly propagating precipitation. The enhanced low‐level moisture is supported by increased wind‐driven LHFLX from stronger regional flows including the Choco and Caribbean Low‐Level Jets and Panama and Papagayo gap winds. Increased offshore convergence and vorticity also help sustain convection during the days with strongly propagating precipitation. Background variations in the physical environment, as opposed to diurnal variations, seem more important for supporting a robust diurnal cycle of precipitation in the region.
Data and Tools Integration in the Canadian Open Neuroscience Platform
Authors: Poline Jean-Baptiste , Das Samir , Glatard Tristan , Madjar Cécile , Dickie Erin W. , Lecours Xavier , Beaudry Thomas , Beck Natacha , Behan Brendan , Brown Shawn T. , Bujold David , Beauvais Michael , Caron Bryan , Czech Candice , Dharsee Moyez , Dugré Mathieu , Evans Ken , Gee Tom , Ippoliti Giulia , Kiar Gregory , Knoppers Bartha Maria , Kuehn Tristan , Le Diana , Lo Derek , Mazaheri Mandana , MacFarlane Dave , Muja Naser , O’Brien Emmet A. , O’Callaghan Liam , Paiva Santiago , Park Patrick , Quesnel Darcy , Rabelais Henri , Rioux Pierre , Legault Mélanie , Tremblay-Mercier Jennifer , Rotenberg David , Stone Jessica , Strauss Ted , Zaytseva Ksenia , Zhou Joey , Duchesne Simon , Khan Ali R. , Hill Sean , Evans Alan C. 
Published: April 2023

AbstractWe present the Canadian Open Neuroscience Platform (CONP) portal to answer the research community’s need for flexible data sharing resources and provide advanced tools for search and processing infrastructure capacity. This portal differs from previous data sharing projects as it integrates datasets originating from a number of already existing platforms or databases through DataLad, a file level data integrity and access layer. The portal is also an entry point for searching and accessing a large number of standardized and containerized software and links to a computing infrastructure. It leverages community standards to help document and facilitate reuse of both datasets and tools, and already shows a growing community adoption giving access to more than 60 neuroscience datasets and over 70 tools. The CONP portal demonstrates the feasibility and offers a model of a distributed data and tool management system across 17 institutions throughout Canada.
Using machine learning to estimate the incidence rate of intimate partner violence
Authors: Chen Zhuo , Ma Wen , Li Ying , Guo Wei , Wang Senhu , Zhang Wansu , Chen Yunsong 
Published: April 2023

AbstractIt is difficult to accurately estimate the incidence rate of intimate partner violence (IPV) using traditional social survey methods because IPV victims are often reluctant to disclose their experiences, leading to an underestimation of the incidence rate. To address this issue, we applied machine learning algorithms to predict the incidence rate of IPV in China based on data from the Third Wave Survey on the Social Status of Women in China (TWSSSCW 2010). Specifically, we examined five unbalanced sample-processing methods and six machine learning algorithms, choosing the random under-sampling ensemble method and the random forest algorithm to impute the missing data. Analysis of the complete data showed that the incidence rates of physical violence, verbal violence, and cold violence were 7.10%, 13.74%, and 21.35%, respectively, which were higher than the incidence rates in the original dataset (4.05%, 11.21%, and 17.95%, respectively). The robustness of our findings was further confirmed by analysis using different training sets. Overall, this study demonstrates that better tools need to be developed to accurately estimate the incidence rates of IPV. It also serves as a useful guide for future research that imputes missing data using machine learning.
Changes in social behavioral developmental risks in preschool children after the first COVID-19 wave: a prospective longitudinal cohort study
Authors: Kästner Anika , Ernst Vanessa Sophie , Hoffmann Wolfgang , Franze Marco 
Published: April 2023

AbstractThe impact of the COVID-19 pandemic on social-emotional developmental risks (SE-DR) of preschool children is largely unknown. Therefore, the aim of this prospective longitudinal dynamic cohort study was to assess changes in preschoolers’ SE-DR from before the pandemic to after the first COVID-19 wave. SE-DR were assessed annually with the instrument “Dortmund Developmental Screening for Preschools” (DESK). Longitudinal DESK data from 3- to 4-year-old children who participated both in survey wave (SW) three (DESK-SW3, 2019) and SW four (DESK-SW4, 2020) from August 1 to November 30 were used, respectively. Additionally, data from previous pre-pandemic SW were analyzed to contextualize the observed changes (SW1: 2017; SW2: 2018). A total of N = 786 children were included in the analysis. In the pre-pandemic DESK-SW3, the proportion of children with SE-DR was 18.2%, whereas in DESK-SW4 after the first COVID-19 wave, the proportion decreased to 12.4% (p = 0.001). Thus, the prevalence rate ratio (PRR) was 0.68. Compared to data from previous SW (SW1-SW2: PRR = 0.88; SW2-SW3: PRR = 0.82), this result represents a notable improvement. However, only short-term effects were described, and the study region had one of the highest preschool return rates in Germany. Further studies are needed to examine long-term effects of the pandemic on preschoolers’ SE-DR.
Removal of hydrocarbons and heavy metals from petroleum water by modern green nanotechnology methods
Authors: Bouafia Abderrhmane , Meneceur Souhaila , Chami Souheyla , Laouini Salah Eddine , Daoudi Henda , Legmairi Souheila , Mohammed Mohammed Hamdi Ali , Aoun Narimene , Menaa Farid 
Published: April 2023

AbstractConsidered heavy metals, such as As(III), Bi(II), Cd(II), Cr(VI), Mn(II), Mo(II), Ni(II), Pb(II), Sb(III), Se(-II), Zn(II), and contaminating chemical compounds (monocyclic aromatic hydrocarbons such as phenolic or polycyclic derivatives) in wastewater (petrochemical industries: oil and gas production plants) are currently a major concern in environmental toxicology due to their toxic effects on aquatic and terrestrial life. In order to maintain biodiversity, hydrosphere ecosystems, and people, it is crucial to remove these heavy metals and polluting chemical compounds from the watery environment. In this study, different Nanoparticles (α-Fe2O3, CuO, and ZnO) were synthesized by green synthesis method using Portulaca oleracea leaf extract and characterized by UV–Vis spectrophotometers, FTIR spectroscopy, X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS) techniques in order to investigate morphology, composition, and crystalline structure of NPs, these were then used as adsorbent for the removal of As(III), Bi(II), Cd(II), Cr(VI), Mn(II), Mo(II), Ni(II), Pb(II), Sb(III), Se(-II), and Zn(II) from wastewater, and removal efficiencies of were obtained 100% under optimal conditions.
Treatment of long ureteric strictures with a free peritoneal graft: long-term results
Authors: Trenti Emanuela , Palermo Salvatore , D'Elia Carolina , Comploj Evi , Ladurner Christian , Gamper Christoph , Pycha Stefan , Palermo Margherita , Pycha Armin 
Published: April 2023

Zusammenfassung
Ziel der Studie Beschreibung einer neuen Technik zur Rekonstruktion von komplexen Ureterstrikturen unter Verwendung eines freien Peritoneallappens.
Material und Methoden Zwischen 2006 und 2021 behandelten wir 11 Patienten mit langen komplexen Harnleiterstrikturen, die in 9 Fällen den mittleren- und in 2 Fällen den proximalen Harnleiter betrafen. Die Länge der Strikturen variierte von 3 bis 12 cm (Mittelwert 7 cm). In drei Fällen handelte es sich um eine retroperitoneale Fibrose nach einem gefäßchirurgischen Eingriff, in zwei Fällen um einen Morbus Ormond, in vier Fällen um eine ausgedehnte Resektion großer Harnleitertumoren, in drei Fällen um wiederholte endoskopische Eingriffe bei Harnsteinen und in einem Fall um eine viermal fehlgeschlagene Pyeloplastik. Der Harnleiter wurde längs gespalten, ein freier Peritoneallappen aus dem nahe gelegenen gesunden Bauchfell entnommen und nach Positionierung eines Harnleiterkatheters als Onlay-Patch mit einer fortlaufenden Naht an der verbleibenden Harnleiterplatte fixiert. Der Ureter wurde zuletzt mit Omentum gedeckt.
Ergebnisse Die Nachbeobachtungszeit reichte von 12 bis 122 (Mittelwert 61,6) Monate. Sieben Patienten waren nach 12, 18, 60, 78, 98, 99 und 122 Monaten (Mittelwert 69,5 Monate) rezidivfrei, ohne Erweiterung des oberen Harntrakts und mit normaler Nierenfunktion. Bei vier Patienten kam es zu einem Rezidiv: Bei einem Patienten wurde das Rezidiv nach 60 Monaten ohne Symptome und mit leichter Hydronephrose festgestellt, ohne dass eine Operation erforderlich war. Bei einem Patienten mit Morbus Ormond trat das Rezidiv 6 Monate nach dem Eingriff symptomlos im distalen Teil des 10 cm langen Omlays auf. Es wurde eine Resektion des stenotischen Segments mit Psoas-Hitch durchgeführt. Bei den beiden anderen Patienten trat 3 und 6 Monate nach dem Eingriff eine Obstruktion unterhalb des rekonstruierten Segments mit Hydronephrose auf, ohne dass die Nierenfunktion beeinträchtigt war. Bei diesen Patienten wurde keine weitere Operation durchgeführt. Die Limitation dieser Studie besteht in der kleinen Studiengröße, die auf die strenge Indikationsstellung zurückzuführen ist.
Schlussfolgerungen Die beschriebene Technik ermöglicht den Erhalt der verbleibenden Gefäßversorgung des Harnleiters und stellt eine praktikable und nützliche Alternative zu Nephrektomie, Ileum-Ureter, Uretero-Uretero-Stomie und Autotransplantation in hochselektierten Fällen dar.
The Dynamic Changes in Skin Thickness of Forehead during Tissue Expansion
Authors: Song Zhen , Zhang Xulong , Xu Yihao , You Jianjun , Wang Huan , Zheng Ruobing , Tian Le , Guo Junsheng , Fan Fei 
Published: April 2023

AbstractIn addition to providing extra flap size, the tissue expansion process also brings changes in flap thickness. This study aims to identify the changes in the forehead flap thickness during the tissue expansion period. Patients undergoing forehead expander embedment from September 2021 to September 2022 were included. The thickness of the forehead skin and subcutaneous tissue were measured with ultrasound before and 1, 2, 3, and 4 months after expansion. Twelve patients were included. The average expansion period was 4.6 months, and the mean expansion volume was 657.1 mL. The thickness of skin and subcutaneous tissue in the central forehead changed from 1.09 ± 0.06 to 0.63 ± 0.05 mm and from 2.53 ± 0.25 to 0.71 ± 0.09 mm, respectively. In the left frontotemporal region, skin and subcutaneous tissue thickness changed from 1.03 ± 0.05 to 0.52 ± 0.05 mm and 2.02 ± 0.21 to 0.62 ± 0.08 mm. On the right side, skin and subcutaneous tissue thickness changed from 1.01 ± 0.05 to 0.50 ± 0.04 mm and 2.06 ± 0.21 to 0.50 ± 0.05 mm. This study measured the dynamic changes in the thickness of the forehead flap during expansion. The thickness of the forehead flap decreased the fastest in the first 2 months of expansion, and the changes in skin and subcutaneous thickness slowed down in the third and fourth months and tended to a minimum value. Additionally, the thickness of subcutaneous tissue decreased greater in magnitude than the dermal tissue.
Latex-Infused Porcine Abdominal Model: A Novel Microsurgery Simulator for Deep Inferior Epigastric Perforator Dissection
Authors: Shaffrey Ellen C. , Zeng Weifeng , Nicksic Peter J. , Eftekari Sahand C. , Frank Jennifer M. , Dingle Aaron M. , Poore Samuel O. 
Published: April 2023

Abstract
Background Perforator dissection and flap elevation are routinely performed for microsurgical reconstruction; however, there is a steep learning curve to mastering these technical skills. Though live porcine models have been utilized as a microsurgical training model, there are significant drawbacks that limit their use, including cost, limited ability for repetition, and obstacles associated with animal care. Here we describe the creation of a novel perforator dissection model using latex augmented non-living porcine abdominal walls. We provide anatomic measurements that demonstrate valuable similarities and differences to human anatomy to maximize microsurgical trainee practice.
Methods Six latex-infused porcine abdomens were dissected based on the deep cranial epigastric artery (DCEA). Dissection was centered over the abdominal wall mid-segment between the second and fourth nipple line. Dissection steps included exposure of lateral and medial row perforators, incision of anterior rectus sheath with perforator dissection, and dissection of DCEA pedicle. DCEA pedicle and perforator measurements were compared with deep inferior epigastric artery (DIEA) data in the literature.
Results An average of seven perforators were consistently identified within each flap. Assembly of the model was performed quickly and allowed for two training sessions per specimen. Porcine abdominal walls demonstrate similar DCEA pedicle (2.6 ± 0.21 mm) and perforator (1.0 ± 0.18 mm) size compared with a human's DIEA (2.7 ± 0.27 mm, 1.1 ± 0.85 mm).
Conclusion The latex-infused porcine abdominal model is a novel, realistic simulation for perforator dissection practice for microsurgical trainees. Impact on resident comfort and confidence within a microsurgical training course is forthcoming.
Megahertz repetition rate-based lock-in detection scheme for rapid data acquisition in terahertz time domain spectroscopy
Authors: Balgos M. H. , Hayazawa N. , Tani M. , Tanaka T. 
Published: April 2023

We report a fast pump modulation scheme in a terahertz time domain spectroscopy (THz-TDS) system by utilizing the intensity modulation from the megahertz repetition rate of the pump pulse for lock-in detection. In conventional THz-TDS, the modulation required for the high signal-to-noise ratio lock-in detection is achieved through the use of an optical chopper or an AC bias. Here, we propose the use of an electro-optic modulator (EOM), operated as a pulse picker, to vary the repetition rate of the pump pulse, relative to the probe pulse, allowing us to directly use the megahertz laser repetition rate as the reference modulation frequency for lock-in detection. Our proposed scheme is applicable to all types of pulsed THz emitters, including those that cannot be electronically biased. Since the maximum allowable modulation frequency is limited only by the laser repetition rate and/or by the bandwidth of the EOM, megahertz modulation rates, and, consequently, rapid data acquisition times, become possible. Using our technique, we were able to detect an oscillating signal with frequencies up to 10 kHz, using ∼1 µs integration time per point, ∼100× faster than previously reported values for THz-TDS systems.
African swine fever virus I73R is a critical virulence-related gene: A potential target for attenuation
Authors: Liu Yingnan , Shen Zhou , Xie Zhenhua , Song Yingying , Li Yao , Liang Rui , Gong Lang , Di Dongdong , Liu Jianqi , Liu Jingyi , Chen Zongyan , Yu Wanqi , Lv Lu , Zhong Qiuping , Liao Xinxin , Tian Chuanwen , Wang Rongrong , Song Qingqing , Wang Heng , Peng Guiqing , Chen Hongjun 
Published: April 2023

African swine fever virus (ASFV) is a large, double-stranded DNA virus that causes a fatal disease in pigs, posing a threat to the global pig industry. Whereas some ASFV proteins have been found to play important roles in ASFV–host interaction, the functional roles of many proteins are still largely unknown. In this study, we identified
I73R
, an early viral gene in the replication cycle of ASFV, as a key virulence factor. Our findings demonstrate that pI73R suppresses the host innate immune response by broadly inhibiting the synthesis of host proteins, including antiviral proteins. Crystallization and structural characterization results suggest that pI73R is a nucleic-acid-binding protein containing a Zα domain. It localizes in the nucleus and inhibits host protein synthesis by suppressing the nuclear export of cellular messenger RNA (mRNAs). While pI73R promotes viral replication, the deletion of the gene showed that it is a nonessential gene for virus replication. In vivo safety and immunogenicity evaluation results demonstrate that the deletion mutant ASFV-GZΔ
I73R
is completely nonpathogenic and provides effective protection to pigs against wild-type ASFV. These results reveal
I73R
as a virulence-related gene critical for ASFV pathogenesis and suggest that it is a potential target for virus attenuation. Accordingly, the deletion mutant ASFV-GZΔ
I73R
can be a potent live-attenuated vaccine candidate.