bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Aplikasi Pemasaran Online Koneksi dengan Marketplace sebagai Strategi Pemasaran untuk Meningkatkan Penjualan bagi UMKM
Authors: Sakti Essy Malays Sari , Aziz Nur , Diantoro Karno 
Published: July 2023

Stategi pemasaran merupakan suatu cara memperkenalkan barang atau jasa guna meningkatkan daya jual produk. Di era teknologi informasi saat ini pemasaran online merupakan salah satu tindakan dari strategi pemasaran yang dapat diandalkan. Oleh karena itu, perlu kiranya untuk rancang sebuah platform aplikasi yang dapat memasarkan produk sehingga dapat dikenal. Aplikasi pemasaran online yang terhubung dengan media sosial dan marketplace menjadi pilihan dan dirancang khusus untuk UMKM guna memperkenalkan produk kepada konsumen dan memanfaatkan marketplace yang berfungsi sebagai tempat jual beli produk. Dalam pengembangan aplikasi pemasaran online ini menggunakan metode Web Development Life Cycle atau WDLC dan untuk rancangan pemodelan sistem dari aplikasi ini menggunakan Unified Modelling Language atau UML. Pengujian terhadap aplikasi pemasaran ini dilakukan untuk mengetahui keberhasilan fungsionalitas dari fitur-fitur yang telah di buat dan pengujian terhadap tampilan dan penggunaanya dilakukan dengan menyebarkan kuesioner pada anggota UMKM. Untuk hasil pengujian menunjukkan bahwa aplikasi sudah sesuai dengan harapan. Untuk penelitian selanjutnya, aplikasi pemasaran ini dapat menjadi sistem informasi pemasaran.
Over 100 mVVOCImprovement for Rear Passivated ACIGS Ultra‐Thin Solar Cells
Authors: Oliveira António , Curado Marco , Teixeira Jennifer , Tomé Daniela , Çaha Ihsan , Oliveira Kevin , Lopes Tomás , Monteiro Margarida , Violas André , Correira Maria , Fernandes Paulo , Deepak Francis , Edoff Marika , Salomé Pedro 
Published: July 2023

AbstractA decentralized energy system requires photovoltaic solutions to meet new aesthetic paradigms, such as lightness, flexibility, and new form factors. Notwithstanding, the materials shortage in the Green Transition is a concern gaining momentum due to their foreseen continuous demand. A fruitful strategy to shrink the absorber thickness, meeting aesthetic and shortage materials consumption targets, arises from interface passivation. However, a deep understanding of passivated systems is required to close the efficiency gap between ultra‐thin and thin film devices, and to mono‐Si. Herein, a (Ag,Cu)(In,Ga)Se2ultra‐thin solar cell, with 92% passivated rear interface area, is compared with a conventional nonpassivated counterpart. A thin MoSe2layer, for a quasi‐ohmic contact, is present in the two architectures at the contacts, despite the passivated device narrow line scheme. The devices present striking differences in charge carrier dynamics. Electrical and optoelectronic analysis combined with SCAPS modelling suggest a lower recombination rate for the passivated device, through a reduction on the rear surface recombination velocity and overall defects, comparing with the reference solar cell. The new architecture allows for a 2% efficiency improvement on a 640 nm ultra‐thin device, from 11% to 13%, stemming from an open circuit voltage increase of 108 mV.
High Thermopower of Agarose‐Based Ionic Thermoelectric Gel Through Micellization Effect Decoupling the Cation/Anion Thermodiffusion
Authors: Li Qikai , Yu Dangkai , Wang Shuaihua , Zhang Xinbo , Li Yuchen , Feng Shien‐Ping , Liu Weishu 
Published: July 2023

AbstractIonic thermoelectric (i‐TE) gels can have a high thermopower, if the thermodiffusion of mobile cation/anion is decoupled, attracting increasing attentions. Herein, it is shown a high p‐type i‐TE thermopower of 41.8 mV K−1in agarose‐based ionic thermoelectric gels of AG‐xNa:DBS (AG: agarose, Na:DBS: sodium dodecyl benzene sulfonate). The exclusively high thermopower is relative to the successfully decoupling the thermodiffusion of cation Na+and anion DBS−. A unique porous structure is formed due to the micellization of the amphiphilic DBS−with the hydrophilic benzenesulfonic group attached to the hydrous agarose gel chains, while the hydrophobic alkyl chain point to the pore centers. As a result, the DBS−micelles are almost immobile as compared with Na+, which can be reconsidered as a part of the gel matrix. The work shines a light on decoupling of cation/anion thermodiffusion through tailoring the microstructure of the quasi‐solid i‐TE materials.
Electroluminescence from GaN‐Based Quantum Dots
Authors: Li Sheng‐Nan , Kong Fan‐Cheng , Yu Yan‐Jun , Meng Shu‐Guang , Qu Zhi‐Hao , Wang Ya‐Kun , Liao Liang‐Sheng 
Published: July 2023

AbstractBulk gallium nitride (GaN) has shown great success in light‐emitting diodes (LEDs), but the use of its counterpart GaN quantum dots (QDs) to obtain electroluminescence has not yet been reported. In this work, the first GaN‐based QLED is demonstrated using Zn‐doped GaN (GaN: Zn) QDs, which is achieved through the combination of trap passivation, energy level adjustment, and morphology engineering. Pure GaN QDs and GaN: Zn QDs are synthesized, and it is found that Zn doping shifts the GaN QD emission from 321 to 377 nm and tunes the highest occupied molecular orbital energy level from 8.6 eV (of original GaN QDs) to 6.9 eV. Multiple washing posttreatment is further developed to improve QD film morphology and size distribution. The optimized GaN: Zn QDs are employed to fabricate solution‐processed LEDs, and the first GaN‐based QLEDs are reported with a maximum quantum efficiency of 0.004%.
Cascade Defluorination of Perfluoroalkylated Catholytes Unlocks High Lithium Primary Battery Capacities
Authors: Gao Haining , Yoshinaga Kosuke , Steinberg Katherine , Swager Timothy M. , Gallant Betar M. 
Published: July 2023

AbstractExceeding the energy density of lithium−carbon monofluoride (Li−CFx), today's leading Li primary battery, requires an increase in fluorine content (x) that determines the theoretical capacity available from C−F bond reduction. However, high F‐content carbon materials face challenges such as poor electronic conductivity, low reduction potentials (<1.3 V versus Li/Li+), and/or low C−F bond utilization. This study investigates molecular structural design principles for a new class of high F‐content fluoroalkyl‐aromatic catholytes that address these challenges. A polarizable conjugated system—an aromatic ring with an alkene linker—functions as electron acceptor and redox initiator, enabling a cascade defluorination of an adjacent perfluoroalkyl chain (RF = −CnF2n+1). The synthesized molecules successfully overcome premature deactivation observed in previously studied catholytes and achieve close‐to‐full defluorination (up to 15/17 available F), yielding high gravimetric capacities of 748 mAh g−1fluoroalkyl‐aromatic and energies of 1785 Wh kg−1fluoroalkyl‐aromatic. The voltage compatibility between fluoroalkyl‐aromatics and CFx enables design of hybrid cells containing C−F redox activity in both solid and liquid phases, with a projected enhancement of Li–CFx gravimetric energy by 35% based on weight of electrodes+electrolyte. With further improvement of cathode architecture, these “liquid CFx” analogues are strong candidates for exceeding the energy limitations of today's primary chemistries.
Coordination and Activation of N2 at Low‐Valent Magnesium using a Heterobimetallic Approach: Synthesis and Reactivity of a Masked Dimagnesium Diradical**
Authors: Mondal Rahul , Evans Matthew J. , Rajeshkumar Thayalan , Maron Laurent , Jones Cameron 
Published: July 2023

AbstractThe activation of dinitrogen (N2) by transition metals is central to the highly energy intensive, heterogeneous Haber–Bosch process. Considerable progress has been made towards more sustainable homogeneous activations of N2 with d‐ and f‐block metals, though little success has been had with main group metals. Here we report that the reduction of a bulky magnesium(II) amide [(TCHPNON)Mg] (TCHPNON=4,5‐bis(2,4,6‐tricyclohexylanilido)‐2,7‐diethyl‐9,9‐dimethyl‐xanthene) with 5 % w/w K/KI yields the magnesium‐N2 complex [{K(TCHPNON)Mg}2(μ‐N2)]. DFT calculations and experimental data show that the dinitrogen unit in the complex has been reduced to the N22− dianion, via a transient anionic magnesium(I) radical. The compound readily reductively activates CO, H2 and C2H4, in reactions in which it acts as a masked dimagnesium(I) diradical.
Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing
Authors: Fu Qiang , Lee Yong Suk , Green Erica A. , Wang Yongdan , Park So Young , Polanco Ashli , Lee Kelvin H. , Betenbaugh Michael , McNally David , Yoon Seongkyu 
Published: July 2023

AbstractRecombinant adeno‐associated virus (rAAV) vectors are a promising platform for in vivo gene therapies. However, cost‐effective, well‐characterized processes necessary to manufacture rAAV therapeutics are challenging to develop without an understanding of how process parameters (PPs) affect rAAV product quality attributes (PQAs). In this work, a central composite orthogonal experimental design was employed to examine the influence of four PPs for transient transfection complex formation (polyethylenimine:DNA [PEI:DNA] ratio, total DNA/cell, cocktail volume, and incubation time) on three rAAV PQAs related to capsid content (vector genome titer, vector genome:capsid particle ratio, and two‐dimensional vector genome titer ratio). A regression model was established for each PQA using partial least squares, and a design space (DS) was defined in which Monte Carlo simulations predicted < 1% probability of failure (POF) to meet predetermined PQA specifications. Of the three PQAs, viral genome titer was most strongly correlated with changes in complexation PPs. The DS and acceptable PP ranges were largest when incubation time and cocktail volume were kept at mid‐high setpoints, and PEI:DNA ratio and total DNA/cell were at low‐mid setpoints. Verification experiments confirmed model predictive capability, and this work establishes a framework for studying other rAAV PPs and their relationship to PQAs.
A Fluorescence‐Based Assay for N5‐Carboxyaminoimidazole Ribonucleotide Mutase
Authors: Sharma Marcella F. , Sharma Shiv K. , Streeter Cale C. , Firestine Steven M. 
Published: July 2023

AbstractThe enzyme N5‐carboxylaminoinidazole ribonucleotide (N5‐CAIR) mutase is found in microbial de novo purine biosynthesis but is absent in humans making it an attractive antimicrobial target. N5‐CAIR mutase catalyzes the synthesis of carboxyaminoimidazole ribonucleotide (CAIR) from N5‐CAIR which is itself prepared from aminoimidazole ribonucleotide (AIR) by the enzyme N5‐CAIR synthetase. During our research on identifying inhibitors of N5‐CAIR mutase, we developed an innovative, fluorescence‐based assay to measure the activity of this enzyme. This assay relies upon our recent serendipitous observation that AIR reversibly reacts with the compound isatin. Reaction of a fluorescently‐tagged isatin with AIR resulted in a large increase in fluorescence intensity allowing a measurement of the concentration of AIR in solution. From this observation, we developed a reproducible, non‐continuous assay that can replicate the known kinetic parameters of the enzyme and can readily detect a recognized inhibitor of the enzyme. This assay should find utility in screening for inhibitors targeting N5‐CAIR mutase.
Investigation of solid particle erosion‐related failures in once‐through steam generators (OTSGs) in oil sands in‐situ production: The limitations of the API RP 14E guideline in OTSG design or operational decision‐making
Authors: Adedeji Oluwaseun Ezekiel , Kumar Anupam , Perdicakis Basil , Sanders R. Sean 
Published: July 2023

AbstractThe required steam for steam‐assisted gravity drainage (SAGD) oil sands operations is generated using a once‐through steam generator (OTSG) that is fed with relatively poor quality process water. Industries have reported possible solid particle erosion‐related failure in the OTSG boiler tubes because of the transport of precipitated dense inorganic particles. However, the presence of other damage mechanisms, e.g. corrosion, flow accelerated corrosion (FAC), often masks the evidence of erosive wear. Also, industries set an upper limit operating velocity for the OTSG using the API RP 14E guideline, which provides no quantitative erosion rates to determine an operating envelope. This study presents a computational fluid dynamics (CFD) analysis of erosion damage in a SAGD OTSG boiler tube. The results revealed that API RP 14E may not be an effective decision‐making tool for operating the OTSG system. For example, a 10% increase in velocity, even at conditions below the API RP 14E threshold, showed a decrease in the failure time of the boiler tubes by 40%–50%.
Color coordination project for the historic shipyard site of La Ciotat: A geopoetic approach to urban color design
Authors: Ollier Xavière 
Published: July 2023

AbstractThe color coordination project focuses on an important industrial heritage site in the Mediterranean—the shipyards of the town of La Ciotat, which is situated in southeastern France. As part of a waterfront requalification project, the company, La Ciotat Shipyards, commissioned a color consulting design agency to collaborate in redeveloping the site and maintaining its unique identity. This article aims to present the color research conducted by the agency Nacarat Color Design in 2018, by putting it into perspective alongside the 1974 work carried out by renowned color designer, Jean‐Philippe Lenclos, on the same industrial site but in a different political, economic, and social context. Applying a geopoetic approach, the color coordination project focuses first on understanding the current identity of the site and its history; second on applying a chromatic field research method; and, third on exploring the narratives brought by the use of color and materials. The complex social history of the shipyards of La Ciotat and its industrial conversion has created new challenges for the town, its inhabitants, and its workers. The conclusions of this study show how color and materials are understood as markers of the site's history, playing not only an important role in the affirmation of historical identity and the creation of a continuity, but also in the construction of a new narrative for a site that reinvents itself.
Goniothalamin prevents lipopolysaccharide‐induced acute lung injury and inflammation via TLR‐4/NF‐κB signaling pathway
Authors: Zou Gongmin , Li Long , Gao LanPing , Zhou YingHong , Ma ZeNan , Hu Zekun 
Published: July 2023

AbstractGoniothalamin (GTN) is a natural compound isolated from Goniothalamus species. It is a potent anti‐inflammatory agent. However, there is a paucity of scientific data about its toxicity. This study investigated GTN's anti‐inflammatory mechanism and lipopolysaccharide (LPS)‐induced lung injury in mice. Mice were distributed into four groups and injected with GTN intraperitoneally (Dosage—50 and 100 mg/kg). We analyzed the wet/dry weight ratio, infiltrated inflammatory cell count, myeloperoxidase (MPO) activity, and histopathological changes in the lung tissues of the mice. Results revealed GTN alleviated LPS‐induced inflammation in mice. Western Blot and enzyme‐linked immunosorbent assay techniques were used to investigate the effect of GTN on pro‐inflammatory cytokines and proteins involved in the MAPK and nuclear factor‐B (NF‐κB) signaling pathways. Cytokines (macrophage migration inhibitory factor, interleukin [IL]‐13, IL‐6, TNF‐α, and IL‐1β) were inhibited by GTN. However, IL‐10 was upregulated. Western blot analysis indicated that GTN suppressed the phosphorylation of jun N‐terminal kinase, nuclear factor NF‐kappa‐B p65, I‐kappa‐B, extracellular signal‐regulated kinases, NF‐κB, and p38. GTN also suppressed the expression of TLR‐4 protein, thereby, inhibiting MAPK and NF‐κB signaling pathways. Thus, GTN can effectively prevent and cure acute lung injury.
MicroRNA‐145‐5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5‐aminoimidazole‐4‐carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Authors: Luo Hao‐Lun , Lee Yi‐Chen , Chang Yin‐Lun , Hsu Wei‐Chi , Wu Yen‐Ting , Jhan Jhen‐Hao , Lin Hui‐Hui , Wu Yi‐Ru , Ke Hung‐Lung , Liu Hui‐Ying 
Published: July 2023

AbstractUpper tract urothelial carcinoma (UTUC), including renal, pelvic, and ureteral carcinoma, has a high incidence rate in Taiwan, which is different from that in Western countries. Therefore, it is imperative to elucidate the mechanisms underlying UTUC growth and metastasis. To explore the function of miR‐145‐5p in UTUC, we transfected the BFTC909 cell line with miR‐145‐5p mimics and analyzed the differences in protein levels by performing two‐dimensional polyacrylamide gel electrophoresis. Real‐time polymerase chain reaction and Western blot analysis were used to analyze 5‐aminoimidazole‐4‐carboxamide ribonucleotide formyltransferase/inositol monophosphate cyclohydrolase (ATIC) messenger RNA and protein levels. A dual‐luciferase assay was performed to identify the target of miR‐145‐5p in ATIC. The effects of miR‐145‐5p and ATIC expression by cell transfection on cell proliferation, migration, and invasion were also assessed. miR‐145‐5p downregulated ATIC protein expression. High ATIC expression is associated with tumor stage, metastasis, recurrence, and a poor prognosis in patients with UTUC. Cell function assays revealed that ATIC knockdown inhibited the proliferation, migration, and invasive abilities of UTUC cells. In contrast, miR‐145‐5p affected the proliferation, migration, and invasive abilities of UTUC cells by directly targeting the 3′‐untranslated regions of ATIC. Furthermore, we used RNA sequencing and Ingenuity Pathway Analysis to identify possible downstream genes regulated by ATIC and found that miR‐145‐5p regulated the protein levels of fibronectin 1, Slug, cyclin A2, cyclin B1, P57, and interferon‐induced transmembrane 1 via ATIC. ATIC may be a valuable predictor of prognosis and a potential therapeutic target for UTUC.
TRIM16 E121D variant affects the risk and prognosis of hepatocellular carcinoma by modulating the Wnt/β‐catenin pathway
Authors: Li Shanfeng , Wang Jialin , Chen Haitao , Hou Jia , Shen Ting , Li Jing , Zhou Bin , Zhang Bo , Liu Hui , Jiang De‐Ke 
Published: July 2023

AbstractTRIM16 has been identified as a tumor suppressor in hepatocellular carcinoma (HCC). This study aimed to investigate whether there are genetic variants in TRIM16 influencing HCC risk and/or prognosis and explore the mechanisms. We performed a gene‐wide single‐nucleotide polymorphism (SNP) mining in TRIM16. The associations of SNPs with both HCC risk and prognosis were assessed through two independent cohorts respectively. Functional experiments were performed to investigate the underlying mechanisms. A missense variant rs2074890 (G > T, resulting in an amino acid substitution from glutamate to aspartate at code 121, E121D) of TRIM16 was found to be associated with both HCC risk (odds ratio = 0.806, p = 0.023) and prognosis (hazard ratio = 0.44, p = 0.034). Compared to the rs2074890 G allele (corresponding to TRIM16121E) homozygote carriers, the rs2074890 T allele (corresponding to TRIM16121D) carriers showed lower HCC risk and better overall survival. Mechanistically, TRIM16121D has stronger ability to inhibit proliferation, migration, and invasion of HCC cells. Furthermore, TRIM16121D could bind to β‐catenin better and mediate K48‐linked ubiquitination to degrade β‐catenin, which leads to inhibition of Wnt/β‐catenin pathway. In conclusion, TRIM16 E121D variant impacts both risk and prognosis of HCC via regulation of Wnt/β‐catenin pathway, which may lead to better understanding the pathogenesis of HCC.
Compact wideband microstrip antennas using C, H, and W‐shape ground plane for GSM band applications
Authors: Deshmukh Amit A. , Chavali Venkata A. P. 
Published: July 2023

AbstractProximity‐fed compact wideband rectangular and circular microstrip antennas by employing H‐shape, C‐shape, and W‐shape ground plane profiles are proposed. Optimum results are obtained in rectangular microstrip antenna using H‐shape ground plane. Against the conventional ground plane, it gives 16% bandwidth improvement, supported by 17.29% and 31% reduction in resonant mode frequency and patch area, respectively. The proposed design exhibits a broadside pattern with a gain of 6.1 dBi and can find applications in GSM 900 band.
Embedding expertise knowledge into inverse treatment planning for low‐dose‐rate brachytherapy of hepatic malignancies
Authors: Zhu Jianjun , Wang Cheng , Teng Sitong , Lu Jian , Lyu Pengju , Zhang Pujun , Xu Jun , Lu Ligong , Teng Gao‐Jun 
Published: July 2023

AbstractBackgroundLeveraging the precision of its radiation dose distribution and the minimization of postoperative complications, low‐dose‐rate (LDR) permanent seed brachytherapy is progressively adopted in addressing hepatic malignancies.PurposeThe present study endeavors to devise a sophisticated treatment planning system (TPS) to optimize LDR brachytherapy for hepatic lesions.MethodsOur TPS encompasses four integral modules: multi‐organ segmentation, seed distribution initialization, puncture pathway selection, and inverse dose planning. By amalgamating an array of deep learning models, the segmentation module proficiently labels 17 discrete abdominal targets within the images. We introduce a knowledge‐based seed distribution initialization methodology that discerns the most analogous tumor shape in the reference treatment plan from the knowledge base. Subsequently, the seed distribution from the reference plan is transmuted to the current case, thus establishing seed distribution initialization. Furthermore, we parameterize the puncture needles and seeds, while concurrently constraining the puncture needle angle through the employment of a virtual puncture panel to augment planning algorithm efficiency. We also presented a user interface that includes a range of interactive features, seamlessly integrated with the treatment planning generation function.ResultsThe multi‐organ segmentation module, which is trained by 50 cases of in‐house CT scans and 694 cases of publicly available CT scans, achieved average Dice of 0.80 and Hausdorff distance of 5.2 mm in testing datasets. The results demonstrate that knowledge‐based initialization exhibits a marked enhancement in expediting the convergence rate. Our TPS also demonstrates a dominant advantage in dose‐volume‐histogram criteria and execution time in comparison to commercial TPS.ConclusionThe study proposes an innovative treatment planning system for low‐dose‐rate permanent seed brachytherapy for hepatic malignancies. We show that the generated treatment plans meet clinical requirement.