bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scientific impact of the National Birth Defects Prevention Network multistate collaborative publications
Authors: Bascom Jacqueline T. , Stephens Sara B. , Lupo Philip J. , Canfield Mark A. , Kirby Russell S. , Nestoridi Eirini , Salemi Jason L. , Mai Cara T. , Nembhard Wendy N. , Forestieri Nina E. , Romitti Paul A. , St. Louis Amanda M. , Agopian A. J. 
Published: July 2023

AbstractBackgroundGiven the lack of a national, population‐based birth defects surveillance program in the United States, the National Birth Defects Prevention Network (NBDPN) has facilitated important studies on surveillance, research, and prevention of major birth defects. We sought to summarize NBDPN peer‐reviewed publications and their impact.MethodsWe obtained and reviewed a curated list of 49 NBDPN multistate collaborative publications during 2000–2022, as of December 31, 2022. Each publication was reviewed and classified by type (e.g., risk factor association analysis). Key characteristics of study populations and analytic approaches used, along with publication impact (e.g., number of citations), were tabulated.ResultsNBDPN publications focused on prevalence estimates (N = 17), surveillance methods (N = 11), risk factor associations (N = 10), mortality and other outcomes among affected individuals (N = 6), and descriptive epidemiology of various birth defects (N = 5). The most cited publications were those that reported on prevalence estimates for a spectrum of defects and those that assessed changes in neural tube defects (NTD) prevalence following mandatory folic acid fortification in the United States.ConclusionsResults from multistate NBDPN publications have provided critical information not available through other sources, including US prevalence estimates of major birth defects, folic acid fortification and NTD prevention, and improved understanding of defect trends and surveillance efforts. Until a national birth defects surveillance program is established in the United States, NBDPN collaborative publications remain an important resource for investigating birth defects and informing decisions related to health services planning of secondary disabilities prevention and care.
Thermoluminescence dosimeter (TLD) studies of Ca10K(PO4)7:Dy phosphor for applications in radiation dosimetry
Authors: Chand Sansar , Mehra Rohit , Chopra Vibha 
Published: July 2023

AbstractThis study reports the thermoluminescence (TL) aspects of Ca10K(PO4)7:Dy phosphor synthesized using a wet chemical method for the first time. The X‐ray diffraction (XRD) results confirm the formation of the desired crystalline phase. Surface morphological studies reveal the formation of polyhedrons and agglomerations having an average diameter of 200 nm, while energy dispersive X‐ray spectroscopy (EDS) data show the presence and composition of the elements in appropriate amounts. The effect of Dy doping concentration has been studied on the TL properties with exposure to gamma radiations from the Co‐60 source. The best TL response has been observed for 5 mol% Dy doping concentration. The glow curve is simple and consists of a single peak at 130°C. The effect of the heating rate has been studied on the TL glow curve, and the heating rate of 5°C/s shows the best TL response. The various TL properties such as annealing conditions, dose–response, TL linearity, fading, and reusability of the prepared phosphor have been studied to check its suitability as a good TL dosimeter (TLD). TL characterization of the phosphor reports that the TL response is linear from 5‐ to 2000 Gy. The results show that this phosphor can be a good TLD for the dosimetry of gamma radiations from Co‐60.
Current challenges and recent advances on the path towards continuous biomanufacturing
Authors: Drobnjakovic Milos , Hart Roger , Kulvatunyou Boonserm (Serm) , Ivezic Nenad , Srinivasan Vijay 
Published: July 2023

AbstractContinuous biopharmaceutical manufacturing is currently a field of intense research due to its potential to make the entire production process more optimal for the modern, ever‐evolving biopharmaceutical market. Compared to traditional batch manufacturing, continuous bioprocessing is more efficient, adjustable, and sustainable and has reduced capital costs. However, despite its clear advantages, continuous bioprocessing is yet to be widely adopted in commercial manufacturing. This article provides an overview of the technological roadblocks for extensive adoptions and points out the recent advances that could help overcome them. In total, three key areas for improvement are identified: Quality by Design (QbD) implementation, integration of upstream and downstream technologies, and data and knowledge management. First, the challenges to QbD implementation are explored. Specifically, process control, process analytical technology (PAT), critical process parameter (CPP) identification, and mathematical models for bioprocess control and design are recognized as crucial for successful QbD realizations. Next, the difficulties of end‐to‐end process integration are examined, with a particular emphasis on downstream processing. Finally, the problem of data and knowledge management and its potential solutions are outlined where ontologies and data standards are pointed out as key drivers of progress.
Embryological basis of polyorchidism including classification, reproductive potential, and risk of malignancy: A review
Authors: Pliszka Anna , Wawrzyniak Agata , Walocha Jerzy , Musiał Agata , Bonczar Michał , Ostrowski Tomasz , Polguj Michał , Wysiadecki Grzegorz , Clarke Edward , Tubbs R. Shane , Balawender Krzysztof 
Published: July 2023

AbstractPolyorchidism, a congenital malformation characterized by supernumerary testes (SNTs), is usually revealed incidentally during ultrasound or open scrotal surgery. In the approximately 200 cases so far published in the literature, the left side is affected more often than the right. Despite the rarity of this anomaly, a surgeon must have basic knowledge of its embryological basis and classifications to implement proper treatment and avoid overlooking it, since the consequences could harm the patient. This review summarizes previous classifications. It can be assumed that determining the risk of malignancy, and the level of reproductive potential based on location, vascularization, ductus deferens drainage, and environmental factors (e.g., temperature) affecting the SNTs, indicates the best approach to management. Therefore, we have created a new classification based on previous ones, addressing the aforementioned issues, which will guide the clinician to select the most appropriate treatment.
Global trends of cancer: The role of diet, lifestyle, and environmental factors
Authors: Bahrami Hassan , Tafrihi Majid 
Published: July 2023

AbstractEffective treatment of cancer requires understanding the nature of the disease and accurately addressing the main root causes. General risk factors for cancer include poor nutrition, an acidogenic diet, an unhealthy lifestyle, and exposure to carcinogens such as toxins, chemicals, and radiation. The risk of developing cancers may be reduced by sufficient oxygenation and maintaining optimal alkalinity and nutritional balance at the cell level. The review paper summarizes some diet and lifestyle modifications that may potentially be considered for preventing and controlling some cancers. Moreover, worldwide statistical data for cancer incidence rates published by International Agency for Research on Cancer are analyzed for certain cancers regionally, concerning the effect of dietary habits and environmental factors that meaningfully correlate with the global trends of cancer. The study of cancer root causes integrated with analyzing the statistics related to cancer incidence rates suggests that the risk of developing cancer may be reduced by modifying dietary habits and lifestyle factors, as well as reducing exposure to carcinogens. Those with healthy balanced dietary habits may have a lower cancer risk than those who frequently have unhealthy diets; hence, considering a balanced natural diet and healthy lifestyle may be suggested as a complementary or alternative solution in cancer treatments.
Design, Synthesis, and Antifungal Activities of Novel Carboxamides Derivatives Bearing a Chalcone Scaffold as Potential SDHIs
Authors: Luo Bo , Zhang Chongchong , Liang Suya , Zhou Wei , Hu Yihan , Li Yulin , Hu Jiayi , Qu Lailiang 
Published: July 2023

AbstractIn search for SDHIs fungicides, twenty‐five novel carboxamides containing a chalcone scaffold were designed, synthesized, and evaluated for antifungal activities against five pathogenic fungi. The results showed that compound 5 k exhibited outstanding antifungal activity against R. solani with an EC50 value of 0.20 μg/mL, which was much better than that of commercial SDHIs Boscalid (EC50=0.74 μg/mL). Moreover, compound 5 k also displayed promising antifungal activities against S. sclerotiorum, B. cinerea, and A. alternate (IC50=2.53–4.06 μg/mL), indicating that 5 k had broad‐spectrum antifungal activity. Additionally, in vivo antifungal activities results showed that 5 k could significantly inhibit the growth of R. solani in rice leaves with good protective efficacy (57.78 %) and curative efficacy (58.45 %) at 100 μg/mL, both of which were much better than those of Boscalid, indicating a promising application prospect. Moreover, SEM analysis showed that compound 5 k could remarkably disrupt the typical structure and morphology of R. solani hyphae. Further SDH enzyme inhibition assay and molecular docking study revealed that lead compound 5 k had a similar mechanism of action as commercial SDHI Boscalid. These results indicated that compound 5 k showed potential as a SDHIs fungicide and deserved further investigation.
Carbon‐based interface engineering and architecture design for high‐performance lithium metal anodes
Authors: Zhu Na , Yang Yuxiang , Li Yu , Bai Ying , Rong Junfeng , Wu Chuan 
Published: July 2023

AbstractMetallic lithium (Li) is considered the “Holy Grail” anode material for the next‐generation of Li batteries with high energy density owing to the extraordinary theoretical specific capacity and the lowest negative electrochemical potential. However, owing to inhomogeneous Li‐ion flux, Li anodes undergo uncontrollable Li deposition, leading to limited power output and practical applications. Carbon materials and their composites with controllable structures and properties have received extensive attention to guide the homogeneous growth of Li to achieve high‐performance Li anodes. In this review, the correlation between the behavior of Li anode and the properties of carbon materials is proposed. Subsequently, we review emerging strategies for rationally designing high‐performance Li anodes with carbon materials, including interface engineering (stabilizing solid electrolyte interphase layer and other functionalized interfacial layer) and architecture design of host carbon (constructing three‐dimension structure, preparing hollow structure, introducing lithiophilic sites, optimizing geometric effects, and compositing with Li). Based on the insights, some prospects on critical challenges and possible future research directions in this field are concluded. It is anticipated that further innovative works on the fundamental chemistry and theoretical research of Li anodes are needed.
Diverse Synthesis of 2H‐Isoindole‐Based Polycyclic Aromatic Compounds
Authors: Kawazoe Teru , Yanai Hikaru , Hagiyama Yuto , Funabiki Kazumasa , Matsumoto Takashi 
Published: July 2023

Abstract1,3‐Disubstituted N‐aryl‐2H‐isoindoles have been synthesized by a cascade reaction of divinyl ethers, which are derived from easily available 4‐bromoisocoumarins, with substituted anilines in HFIP. This cascade reaction consists of a ring‐opening step through addition‐elimination mechanism and the following 5‐exo‐tet type ring‐closing step via the intramolecular nucleophilic substitution reaction. Thus obtained 2H‐isoindoles have been derivatized to high‐order nitrogen‐containing polycycles including less accessible benzo[a]ullazines.
PROTOCOL: Impact of summer programmes on the outcomes of disadvantaged or at risk young people: A systematic review
Authors: Muir Daniel , Newton Becci , Orlando Cristiana 
Published: July 2023

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows: based on the findings of the initial literature review regarding the types of summer programmes used to support disadvantaged or at risk young people, the outcomes they aim to affect and the goals of the funding organisations and research team, this review will seek to answer the following research questions: (1) to what extent does participation in summer employment programmes improve outcomes for disadvantaged or at risk young people, (2) to what extent does participation in summer educational programmes improve outcomes for disadvantaged or at risk young people, and (3) to what extent do the impacts of summer programmes vary based on the study, participant and intervention characteristics including the racial and ethnic make‐up of participants?
Integrability of Einstein deformations and desingularizations
Authors: Ozuch Tristan 
Published: July 2023

AbstractWe study the question of the integrability of Einstein deformations and relate it to the question of the desingularization of Einstein metrics. Our main application is a negative answer to the long‐standing question of whether or not every Einstein 4‐orbifold (which is an Einstein metric space in a synthetic sense) is limit of smooth Einstein 4‐manifolds. We more precisely show that spherical and hyperbolic 4‐orbifolds with the simplest singularities cannot be Gromov‐Hausdorff limits of smooth Einstein 4‐metrics without relying on previous integrability assumptions. For this, we analyze the integrability of deformations of Ricci‐flat ALE metrics through variations of Schoen's Pohozaev identity. Inspired by Taub's conserved quantity in General Relativity, we also introduce conserved integral quantities based on the symmetries of Einstein metrics. These quantities are obstructions to the integrability of infinitesimal Einstein deformations “closing up” inside a hypersurface – even with change of topology. We show that many previously identified obstructions to the desingularization of Einstein 4‐metrics are equivalent to these quantities on Ricci‐flat cones. In particular, all of the obstructions to desingularizations bubbling off Eguchi‐Hanson metrics are recovered. This lets us further interpret the obstructions to the desingularization of Einstein metrics as a defect of integrability.
Kraft Lignin: A Valuable, Sustainable Resource, Opportunities and Challenges
Authors: Argyropoulos Dimitris D. S. , Crestini Claudia , Dahlstrand Christian , Furusjö Erik , Gioia Claudio , Jedvert Kerstin , Henriksson Gunnar , Hulteberg Christian , Lawoko Martin , Pierrou Clara , Samec Joseph S. M. , Subbotina Elena , Wallmo Henrik , Wimby Martin 
Published: July 2023

AbstractKraft lignin, a by‐product from the production of pulp, is currently incinerated in the recovery boiler during the chemical recovery cycle, generating valuable bioenergy and recycling inorganic chemicals to the pulping process operation. Removing lignin from the black liquor or its gasification lowers the recovery boiler load enabling increased pulp production. During the past ten years, lignin separation technologies have emerged and the interest of the research community to valorize this underutilized resource has been invigorated. The aim of this Review is to give (1) a dedicated overview of the kraft process with a focus on the lignin, (2) an overview of applications that are being developed, and (3) a techno‐economic and life cycle asseeements of value chains from black liquor to different products. Overall, it is anticipated that this effort will inspire further work for developing and using kraft lignin as a commodity raw material for new applications undeniably promoting pivotal global sustainability concerns.
Recent Advances in Transfer‐Free Synthesis of High‐Quality Graphene
Authors: Li Yinghan , Zhou Kaixuan , Ci Haina , Sun Jingyu 
Published: July 2023

AbstractHigh‐quality graphene obtained by chemical vapor deposition (CVD) technique holds significant importance in constructing innovative electronic and optoelectronic devices. Direct growth of graphene over target substrates readily eliminates cumbersome transfer processes, offering compatibility with practical application scenarios. Recent years have witnessed growing strategic endeavors in the preparation of transfer‐free graphene with favorable quality. Nevertheless, timely review articles on this topic are still scarce. In this contribution, a systematic summary of recent advances in transfer‐free synthesis of high‐quality graphene on insulating substrates, with a focus on discussing synthetic strategies designed by elevating reaction temperature, confining gas flow, introducing growth promotor and regulating substrate surface is presented.
A biometric‐based implicit authentication protocol with privacy protection for ubiquitous communication environments
Authors: Liu Feng , Liu Hongyue , Kannadasan R. , Jiang Qi 
Published: July 2023

SummaryDue to the proliferation of the wireless communication technologies, we are now in the era of ubiquitous computing. People can enjoy services almost in any time and any location based on the mobile intelligent devices. Meanwhile, more and more personal information are transmitted through the network. To protect these sensitive information, authentication and privacy protection are primary concerns in ubiquitous communication environments. However, traditional physical‐based biometric authentication scheme usually requires explicit cooperation of the user, which is inconvenient to the users. In order to solve this problem, a behavior biometric authentication protocol with privacy protection is designed using matrix multiplication and homomorphic encryption for ubiquitous communication environments. The correctness, security, and privacy protection properties are proved with security analysis. Performance evaluation shows that our protocol achieves stronger security and higher communication efficiency compared with other related protocols, which makes it very suitable for ubiquitous communication environments because communication consumes much more energy than computation does in mobile communication.
A robust harmonization approach for cognitive data from multiple aging and dementia cohorts
Authors: Giorgio Joseph , Tanna Ankeet , Malpetti Maura , White Simon R. , Wang Jingshen , Baker Suzanne , Landau Susan , Tanaka Tomotaka , Chen Christopher , Rowe James B. , O'Brien John , Fripp Jurgen , Breakspear Michael , Jagust William , Kourtzi Zoe ,   for the Alzheimer's Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle flagship study
Published: July 2023

AbstractINTRODUCTIONAlthough many cognitive measures have been developed to assess cognitive decline due to Alzheimer's disease (AD), there is little consensus on optimal measures, leading to varied assessments across research cohorts and clinical trials making it difficult to pool cognitive measures across studies.METHODSWe used a two‐stage approach to harmonize cognitive data across cohorts and derive a cross‐cohort score of cognitive impairment due to AD. First, we pool and harmonize cognitive data from international cohorts of varying size and ethnic diversity. Next, we derived cognitive composites that leverage maximal data from the harmonized dataset.RESULTSWe show that our cognitive composites are robust across cohorts and achieve greater or comparable sensitivity to AD‐related cognitive decline compared to the Mini‐Mental State Examination and Preclinical Alzheimer Cognitive Composite. Finally, we used an independent cohort validating both our harmonization approach and composite measures.DISCUSSIONOur easy to implement and readily available pipeline offers an approach for researchers to harmonize their cognitive data with large publicly available cohorts, providing a simple way to pool data for the development or validation of findings related to cognitive decline due to AD.
Thimet oligopeptidase as a potential CSF biomarker for Alzheimer's disease: A cross‐platform validation study
Authors: Hok‐A‐Hin Yanaika S. , Bolsewig Katharina , Ruiters Daimy N. , Lleó Alberto , Alcolea Daniel , Lemstra Afina W. , van der Flier Wiesje M. , Teunissen Charlotte E. , del Campo Marta 
Published: July 2023

AbstractINTRODUCTIONOur previous antibody‐based cerebrospinal fluid (CSF) proteomics study showed that Thimet oligopeptidase (THOP1), an amyloid beta (Aβ) neuropeptidase, was increased in mild cognitive impairment with amyloid pathology (MCI‐Aβ+) and Alzheimer's disease (AD) dementia compared with controls and dementia with Lewy bodies (DLB), highlighting the potential of CSF THOP1 as an early specific biomarker for AD. We aimed to develop THOP1 immunoassays for large‐scale analysis and validate our proteomics findings in two independent cohorts.METHODSWe developed in‐house CSF THOP1 immunoassays on automated Ella and Simoa platforms. The performance of the different assays were compared using Passing–Bablok regression analysis in a subset of CSF samples from the discovery cohort (n = 72). Clinical validation was performed in two independent cohorts (cohort 1: n = 200; cohort 2: n = 165) using the Ella platform.RESULTSTHOP1 concentrations moderately correlated between proteomics analysis and our novel assays (Rho > 0.580). In both validation cohorts, CSF THOP1 was increased in MCI‐Aβ+ (>1.3‐fold) and AD (>1.2‐fold) compared with controls; and between MCI‐Aβ+ and DLB (>1.2‐fold). Higher THOP1 concentrations were detected in AD compared with DLB only when both cohorts were analyzed together. In both cohorts, THOP1 correlated with CSF total tau (t‐tau), phosphorylated tau (p‐tau), and Aβ40 (Rho > 0.540) but not Aβ42.DISCUSSIONValidation of our proteomics findings underpins the potential of CSF THOP1 as an early specific biomarker associated with AD pathology. The use of antibody‐based platforms in both the discovery and validation phases facilitated the translation of proteomics findings, providing an additional workflow that may accelerate the development of biofluid‐based biomarkers.