bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influential role of hotel-generated content on social media
Authors: Veloso Mónica , Gomez-Suarez Monica 
Published: January 2023

Purpose
This study aims to determine how hotel-generated content (HGC) on official social media accounts influences booking intention by considering the mediating role of three key constructs: user evaluations of the perceived quality of information, engagement and brand attitude.

Design/methodology/approach
A total of 834 valid online questionnaires were collected to empirically test the measurement and structural model using a partial least square path modeling approach.

Findings
Although HGC does not have a direct effect on booking intention, this construct has a positive influence on both the perceived quality of information and engagement, which in turn positively influence booking intention. In addition, greater engagement generates a positive attitude, which increases booking intention.

Originality/value
This study represents a new step in understanding the influence of HGC on tourist behavior by extending research on guests’ decision-making processes and empirically demonstrating the chain of related influences that begins with HGC to promote booking intention.
Postpartum home blood pressure monitoring and lifestyle intervention in overweight and obese individuals the first year after gestational hypertension or pre‐eclampsia: A pilot feasibility trial
Authors: Hauspurg Alisse , Seely Ellen W. , Rich‐Edwards Janet , Hayduchok Christina , Bryan Samantha , Roche Andrea T. , Jeyabalan Arun , Davis Esa M. , Hart Renee , Shirriel Jada , Catov Janet 
Published: January 2023

AbstractObjectiveTo test the feasibility of a randomised trial of home blood pressure monitoring paired with a remote lifestyle intervention (Heart Health 4 New Moms) versus home blood pressure monitoring alone versus control in individuals with a hypertensive disorder of pregnancy in the first year postpartum.DesignSingle‐blinded three‐arm randomised clinical trial.SettingTwo tertiary care hospitals and a community organisation.PopulationPostpartum overweight and obese individuals with a hypertensive disorder of pregnancy and without pre‐pregnancy hypertension or diabetes.MethodsWe assessed the feasibility of recruitment and retention of 150 participants to study completion at 1‐year postpartum with randomisation 1:1:1 into each arm. Secondary aims were to test effects of the interventions on weight, blood pressure and self‐efficacy.ResultsOver 23 months, we enrolled 148 of 400 eligible, screened individuals (37%); 28% black or other race and mean pre‐pregnancy body mass index (BMI) of 33.4 ± 6.7 kg/m2. In total, 129 (87%) participants completed the 1‐year postpartum study visit. Overall, 22% of participants developed stage 2 hypertension (≥140/90 mmHg or on anti‐hypertensive medications) by 1 year postpartum. There were no differences in weight or self‐efficacy across the study arms.ConclusionIn this pilot, randomised trial, we demonstrate feasibility of HBPM paired with a lifestyle intervention in the first year postpartum. We detected high rates of ongoing hypertension, emphasising the need for the development of effective interventions in this population.
Serial plotting of symphysis–fundal height and estimated fetal weight to improve the antenatal detection of infants small for gestational age: A cluster randomised trial
Authors: Ego Anne , Monier Isabelle , Vilotitch Antoine , Kayem Gilles , Vayssiere Christophe , Verspyck Eric , Zeitlin Jennifer ,   for the HPAG (Hauteur utérine et Petit poids pour l'Age Gestationnel) Study Group and the Groupe de Recherche en Obstétrique et Gynécologie (GROG)
Published: January 2023

AbstractObjectiveTo assess whether standardised longitudinal reporting of growth monitoring information improves antenatal detection of infants who are small for gestational age (SGA), compared with usual care.DesignCluster‐randomised controlled trial.SettingSixteen French level‐3 units in 2018–2019.PopulationSingleton pregnancies.MethodsThe intervention consisted of the serial plotting of symphysis–fundal height (SFH) and estimated fetal weight (EFW) measurements on customised growth charts using a software program, compared with standard antenatal care. We estimated relative risks (RR) adjusted for known risk factors for fetal growth restriction (FGR).Main Outcome MeasuresThe primary outcome was antenatal detection of FGR among SGA births (with birthweights below the tenth centile of French customised curves), defined as the mention of suspected FGR in medical records and either referral ultrasounds for growth monitoring or indicated delivery for FGR. Secondary outcomes were false‐positive rates, mode of delivery, perinatal morbidity and mortality, and number of antenatal visits and ultrasounds.ResultsIn total, seven intervention clusters (n = 4349) and eight control clusters (n = 4943) were analysed, after the exclusion of one intervention centre for a major deviation in protocol. SGA births represented 613 (14.1%) and 626 (12.7%) of all births, respectively. The rates of antenatal detection of FGR among SGA births were 40.0% in the intervention arm versus 37.1% in the control arm (crude RR 1.08, 95% CI 0.87–1.34; adj RR 1.09, 95% CI 0.88–1.35). No benefits of the intervention were detected in the analyses of secondary outcomes.ConclusionsSerial plotting of SFH and EFW measurements on customised growth charts did not improve the antenatal detection of FGR among SGA births.
The economic effects of real estate investors
Authors: Garriga Carlos , Gete Pedro , Tsouderou Athena 
Published: January 2023

AbstractWe show five new results about small‐ and medium‐sized real estate investors (SMREI) who participate through legal entities in US housing markets. First, SMREI have the largest growth across all cities post Great Recession, in contrast to Wall Street Landlords who concentrate in superstar cities. Second, SMREI increase house price growth and price‐to‐income ratio, especially in the bottom price tier. Third, this effect is reversed as investors trigger a medium‐run supply response. Fourth, in areas with a high supply elasticity, SMREI affect rents more than prices. Finally, SMREI change the composition of the housing stock in favor of multifamily units.
Old age and EGFR mutation status in inoperable early‐stage non‐small cell lung cancer patients receiving stereotactic ablative radiotherapy: A single institute experience of 71 patients in Taiwan
Authors: Wu Yuan‐Hung , Kang Yu‐Mei , Hu Yu‐Wen , Lan Keng‐Li , Yen Sang‐Hue , Lai Tzu‐Yu , Lan Tien‐Li , Chen Yuh‐Min , Chiu Chao‐Hua , Luo Yung‐Hung , Chao Heng‐sheng , Chiang Chi‐Lu , Shiao Tsu‐Hui , Yang Chao‐Neng , Hsu Wen‐Hu , Wu Yu‐Chung , Hsu Han‐Shui , Hung Jung‐Jyh , Huang Chien‐Sheng , Hsu Po‐Kuei , Chen Yi‐Wei 
Published: January 2023

AbstractBackgroundStereotactic ablative radiotherapy (SABR) is now the standard of care for patients with inoperable early‐stage lung cancer. Many of these patients are elderly. EGFR (epidermal growth factor receptor) mutation is also common in the Asian population.MethodsTo evaluate the effects of old age and EGFR mutation on treatment outcomes and toxicity, we reviewed the medical records of 71 consecutive patients with inoperable early‐stage non‐small cell lung cancer (NSCLC) who received SABR at Taipei Veterans General Hospital between 2015 and 2021.ResultsThe study revealed that median age, follow‐up, Charlson comorbidity index, and ECOG score were 80 years, 2.48 years, 3, and 1, respectively. Of these patients, 37 (52.1%) were 80 years or older, and 50 (70.4%) and 21 (29.6%) had T1 and T2 diseases, respectively. EGFR mutation status was available for 33 (46.5%) patients, of whom 16 (51.5%) had a mutation. The overall survival rates at 1, 3, and 5 years were 97.2, 74.9, and 58.3%, respectively. The local control rate at 1, 3, and 5 years was 97.1, 92.5, and 92.5%, respectively. Using Cox proportional hazards regression we found that male sex was a risk factor for overall survival (p = 0.036, 95% CI: 1.118–26.188). Two patients had grade 2 pneumonitis, but no other grade 2 or higher toxicity was observed. We did not find any significant differences in treatment outcomes or toxicity between patients aged 80 or older and those with EGFR mutations in this cohort.ConclusionThese findings indicate that age and EGFR mutation status do not significantly affect the effectiveness or toxicity of SABR for patients with inoperable early‐stage NSCLC.
Photosynthetic characteristics of the invasive weed Chromolaena odorata and other co‐occurring species in KwaZulu‐Natal
Authors: Naidoo Kubendran Kista , Naidoo Gonasageran 
Published: January 2023

AbstractIn this study, we tested the hypothesis that photosynthetic characteristics contributed to the success and spread of the invasive, C3 perennial weed, Chromolaena odorata (L.) R. M. King & H. Rob. Measurements of gas exchange, chlorophyll fluorescence and water relations parameters were taken in summer and winter, as well as in sun and shade plants. Typically, diurnal CO2 exchange increased from dawn to a mid‐morning maximum between 10:00 h and 11:00 h, and thereafter decreased gradually for the rest of the day. Light response curves indicated saturation of CO2 uptake and electron transport rate (ETR) through Photosystem II (PSII) at a photosynthetic photon flux density (PPFD) ≥1800 μmol m−2 s−1. Maximal CO2 exchange was 15.64 ± 0.87 (±SE) in summer and 13.15 ± 0.26 μmol m−2 s−1 in winter. Leaf conductance (g), CO2 uptake (A) and transpiration (E) followed trends similar to those for PPFD. Leaf water potential (Ψ) and water use efficiency (WUE) declined from the predawn maximum values to a minimum at midday and thereafter recovered at dusk. Diurnal trends in actual quantum yield (ΦPSII) and maximum quantum yield (Fv/Fm) decreased from dawn to a minimum at midday, followed by complete recovery at dusk. The relationship between A and g, and A and ETR was linear. Trends in A, ΦPSII and ETR through PSII were tightly coupled to those of incident PPFD. Efficient light utilisation is achieved through modifying plastic traits such as leaf size, specific leaf area and chlorophyll content. Chromolaena is a facultative shade‐tolerant weed that exhibits superior light utilisation to maximise carbon gain, while efficient photoprotective mechanisms minimise photoinhibition and photodamage to the photosystems. These adaptive architectural and physiological strategies may probably confer competitive advantage over other species.
Human impacts on mammal communities in Rio Campo Nature Reserve, Equatorial Guinea
Authors: DeGroot Tiff L. , Wolfe Jared D. , Powell Luke L. , Esono Fidel , Ebana Agustín , Barrientos Christian , Torrent Laura , Brzeski Kristin E. 
Published: January 2023

AbstractEquatorial Guinea in central Africa hosts rich biodiversity and a network of protected areas (PAs). However, infrastructure development has facilitated access to previously remote forests. This has likely increased poaching in PAs, thereby complicating efforts of agencies tasked with protecting threatened mammals. Reserva Natural de Río Campo (RNRC) in Equatorial Guinea was previously identified as a priority area for large mammals due to the presence of elephants and great apes and includes habitat for a diverse mammal community of commonly hunted species. To assess mammalian diversity in RNRC, we conducted a camera trap survey in 2017 and 2019. We used a two‐step modelling approach to quantify environmental and anthropogenic factors influencing mammal groups. We detected 32 terrestrial mammal species, including endangered forest elephant, western gorilla, chimpanzee, giant pangolin and white‐bellied pangolin. We found bushbuck and sitatunga closer to human‐dominated areas, while other common species were, in general, further from development. Monkey and pangolin abundance increased inward from the RNRC boundary. Endangered species appear restricted to northeast RNRC which connects to Campo Ma'an National Park in Cameroon. We recommend using our inventory and distributions of threatened mammals as starting points to determine effectiveness of future anti‐poaching and management strategies on mammal populations.
A 20‐million‐year Early Jurassic cyclostratigraphic record and its implications for the chaotic inner Solar System and sea‐level changes
Authors: Charbonnier Guillaume , Boulila Slah , Galbrun Bruno , Laskar Jacques , Gardin Silvia , Rouget Isabelle 
Published: January 2023

AbstractWe present high‐resolution (every 2 cm) magnetic susceptibility (MS) data from the Sancerre‐Couy drill core (Paris Basin), spanning the latest Sinemurian to the earliest Aalenian (Early Jurassic). This record allows to build a 20‐million‐year cyclostratigraphic interval using the stable 405 kyr (g2–g5) orbital eccentricity cycle and to focus on long‐period cyclicities and their potential implications for the chaotic diffusion in the inner Solar System and sea‐level changes. Time series analysis indicates evidence of two long‐period cyclicities of 1.6 and 3.4 Myr. These Early Jurassic cyclicities likely correspond to the Cenozoic orbital cyclicities of 2.4 Myr (g4–g3) and 4.7 Myr eccentricity terms. Shortening of eccentricity terms during the Early Jurassic is potentially related to the chaotic orbital motion of the inner planets expressed in the resonant argument θ = 2(g4–g3) − (s4–s3). The 1.6 Myr (g4–g3) cycle matches the third‐order eustatic sequences, whereas the 3.4 Myr cycle has no equivalent in the reference eustatic chart. These cycles of several million years are superimposed a cyclicity of ca. 7.5 Myr, which may correspond to the eccentricity term of 9.5 Myr, previously detected in the Cenozoic. Such cyclicity matches the global, ‘shorter’ second‐order sea‐level sequences and is strongly documented in the sedimentological and mineralogical proxy data, hence supporting the potential key role of orbitally paced climate and sea‐level changes at this timescale.
The intersections of race, immigrant status, and university confirmations in Toronto
Authors: Malette Nicole , Robson Karen 
Published: January 2023

AbstractAlthough the number of students attending university has been steadily increasing over the past 20 years, discrepancies remain across racialized student groups. Students who immigrate to Canada also face a number of barriers to university participation. However, few studies investigate variations in university participation across racialized immigrant student groups. We draw on an intersectional approach to analyze student data from the Toronto District School Board. We employ multilevel logistic regression to examine if there are interactive effects of being both racialized and having an immigrant status on confirming a university enrollment. Looking at self‐identified race and immigrant status of students in combination reveals that there are important differences in the likelihood of confirming and offer of university admission between several self‐identified racial categories, depending on if they were foreign‐born.
Exploring ethnic differences in post‐discharge patterns of surgical care for older adults admitted with diverticulitis
Authors: Tong Jason K. C. , Mascuilli Tory , Wirtalla Christopher , Aarons Cary B. , Saur Nicole M. , Mahmoud Najjia N. , Kelz Rachel R. 
Published: January 2023

AbstractAimWe aimed to evaluate ethnic differences in patterns of care following an index nonoperative admission for acute diverticulitis amongst a universally insured patient cohort.MethodsWe identified nationwide Medicare beneficiaries aged 65.5 years or older hospitalized between 1 July 2015 and 1 November 2017 for nonoperative management of an index admission for diverticulitis. Patients were followed for 1 year to examine patterns of care. Primary categorical outcomes included receipt of an elective operation, emergency operation, nonoperative readmission or no further hospitalizations for diverticulitis. Multinomial regression was performed to determine the association between ethnicity and receipt of each primary outcome category whilst adjusting for potential confounders. We examined the use of percutaneous drainage during the index admission to better understand its association with subsequent care patterns.ResultsAmongst 22 630 study patients, subsequent operative treatment was less common for Black, Hispanic, Asian and American Indian patients relative to White patients. Multinomial logistic regression noted that Black (relative risk 0.40; 95% CI 0.32–0.50) and Asian (relative risk 0.37; 95% CI 0.15–0.91) patients were associated with the lowest relative risk of undergoing an elective interval operation compared to White patients. Black patients were also associated with a 1.43 (95% CI 1.19–1.73) increased risk of requiring subsequent nonoperative readmissions for disease recurrence compared to White patients. The use of percutaneous drainage was higher amongst White patients relative to Black patients (6.9% vs. 4.0%, P value < 0.001).ConclusionWe have identified ongoing inequities in the consumption of medical resources, with White patients being more likely to undergo elective colectomy and percutaneous drainage. Differences in care are not fully alleviated by equal access to insurance.
The risk of lymph node metastasis in patients with T2 colon cancer
Authors: Hartwig Morten F. , Slumstrup Lasse , Fiehn Anne‐Marie Kanstrup , Gögenur Ismail 
Published: January 2023

AbstractAimIt is often safe to treat pT1 tumours with local resection due to the low risk of lymph node metastasis. The risk of lymph node metastasis in pT2 colon cancer is less well investigated. The recommendation for patients diagnosed with T2 colon cancer is a segmental resection including regional lymph nodes. The aim of this work was to determine the risk of lymph node metastasis in pT2 colon cancer and identify the possible associated clinical and pathological risk factors for lymph node metastasis.MethodPubMed and Embase were systematically searched for studies describing patients with T2 colon cancer and lymph node status after histopathological assessment. Lymph node metastasis and the effect of histological and clinical factors were included.ResultsOverall, 5489 studies were screened, and 10 studies consisting of a total of 91 460 patients were included in the review. The overall risk of lymph node metastasis was 19.3% (95% confidence interval 19.0%–19.5%). A meta‐analysis was not possible as very few studies described the clinical and pathological risk factors for lymph node metastasis.ConclusionThe risk of lymph node metastasis in patients with pT2 colon cancers is higher than for pT1. The studies included patients operated on from 1985 to 2015 with variations in surgical procedure, pathological handling, and definition of lymph node metastasis. Further studies reporting risk factors for lymph node metastasis in pT2 colon cancer are warranted as more data are needed to determine if local resection for a subgroup of patients could be an alternative treatment modality.
Long‐term cost‐effectiveness analysis of tirzepatide versus semaglutide 1.0 mg for the management of type 2 diabetes in the United States
Authors: Valentine William J. , Hoog Meredith , Mody Reema , Belger Mark , Pollock Richard 
Published: January 2023

AbstractAimTo evaluate the long‐term cost‐effectiveness of tirzepatide (5, 10 and 15 mg doses), a novel glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) receptor agonist, versus semaglutide 1.0 mg, an injectable glucagon‐like peptide‐1 receptor agonist, based on the results of the head‐to‐head SURPASS‐2 trial, from a US healthcare payer perspective.Materials and MethodsThe PRIME Type 2 Diabetes Model was used to make projections of clinical and cost outcomes over a 50‐year time horizon. Baseline cohort characteristics, treatment effects and adverse event rates were derived from the 40‐week SURPASS‐2 trial. Intensification to insulin therapy occurred when HbA1c reached 7.5%, in line with American Diabetes Association recommendations. Direct costs in 2021 US dollars (US$) and health state utilities were derived from published sources. Future costs and clinical benefits were discounted at 3% annually.ResultsAll three doses of tirzepatide were associated with lower diabetes‐related complication rates, improved life expectancy, improved quality‐adjusted life expectancy and higher direct costs versus semaglutide. This resulted in incremental cost‐effectiveness ratios of US$ 75 803, 58 908 and 48 785 per quality‐adjusted life year gained for tirzepatide 5, 10 and 15 mg, respectively, versus semaglutide. Tirzepatide remained cost‐effective versus semaglutide over a range of sensitivity analyses.ConclusionsLong‐term projections based on the SURPASS‐2 trial results indicate that 5, 10 and 15 mg doses of tirzepatide are likely to be cost‐effective versus semaglutide 1.0 mg for the treatment of type 2 diabetes in the United States.
When type II diabetes mellitus meets COVID‐19—Identification of the shared gene signatures and biological mechanism between the two diseases
Authors: Zhao Tianyu , Ding JiPeng , Liang Zuowen , Cui Xiaoli , He Kan , Chen Li , Li Jing 
Published: January 2023

AbstractBackgroundAccording to current studies, more than 20% of all patients diagnosed with COVID‐19 globally have diabetes. Further, the mortality rate of these patients is 7.3%. Compared with non‐diabetic COVID‐19 patients, diabetic COVID‐19 patients have higher rates of mortality and severe infection, suggesting that diabetes is associated with the severity of COVID‐19 infection. This study aimed to analyse the relationship and susceptibility factors between COVID‐19 and T2DM.MethodsUsing bioinformatics methods, potential targets for COVID‐19 and T2DM were screened from GeneCards database. Potential targets of COVID‐19 and T2DM were mapped to each other to identify overlapping targets, and a PPI network was constructed to extract the core target. The clusterProfiler package in R was used to analyse the function and pathway that core target involved. GO enrichment and KEGG pathway analysis were used to elucidate the correlation between COVID‐19 and T2DM.ResultsA total of 277 potential pathogenic targets of COVID‐19 were found, 282 potential targets were found for T2DM. Mapping of the potential COVID‐19 and T2DM targets revealed 53 overlapping targets, with TNF as the core target. IL‐17 signalling pathway was the most significant KEGG pathway involving TNF.ConclusionsThe inflammatory cytokine, TNF, was identified as a core target between COVID‐19 and T2DM, which induces inflammatory response mainly through the IL‐17 signalling pathway, leading to aggravation of infection and increased difficulty in blood glucose control. This study provides a reference for further exploring the potential correlation and endogenous mechanisms between two seemingly independent and unrelated diseases—T2DM and COVID‐19.