bluuebunny/crossref_metadata_2025_split huggingface dataset:
HBAC Algorithm for Enhancement of Makespan and improved Task allocation for VM in cloud datacenter
Authors: Ullah Arif , Alam Tanweer , Abbasi Irshad Ahmed , ŞAHİN Canan BATUR , Abualigah Laith 
Published: March 2023

Abstract
Regardless of the past research work in cloud computing some of the challenges still exist related to workload distribution in cloud data centers. Especially in the infrastructure as a service IaaS cloud model. Efficient task allocation is a crucial process in cloud data center due to the restricted number of resource and virtual machines (VM). IaaS is one of the main models of cloud computing because this model handles the backend where servicer like VM and data centers are managed. Cloud service providers should ensure high service delivery performance in such models avoiding situations such as hosts being overloaded or under loaded as this result causes VM failure and make higher network execution time. Therefore, to overcome these problems, this paper proposed an improved load balancing technique known as the HBAC algorithm which dynamically allocates resources by hybridizing the Artificial Bee Colony (ABC) algorithm with the Bat algorithm. The proposed HBAC algorithm was tested and compared with other state-of-the-art algorithms on 200-20000 even tasks by using CloudSim on standard workload format (SWF) data sets file size (200kb and 400kb). The proposed HBAC showed an improved accuracy rate in task distribution of VM in a cloud datacenter and reduced the makespan (energy level) in the datacenter. Based on the ANOVA comparison test results, a 1.98 percent improvement on accuracy or task distribution of VM occurs and 0.98 percent reduced makespan or energy level of cloud data center. The results are consistent with different services broker policies which are used during simulation process for the proposed algorithm in cloud datacenter. In future research the proposed algorithm used for predication approach for resource managements system in cloud data center.
Decoherence as a high-dimensional geometrical phenomenon
Authors: Soulas Antoine 
Published: March 2023

Abstract
We develop a mathematical formalism that allows to study decoherence with a great level generality, so as to make it appear as a geometrical phenomenon between reservoirs of dimensions. It enables us to give quantitative estimates of the level of decoherence induced by a purely random environment on a system according to their respectives sizes, and to exhibit some links with entanglement entropy.
Detecting Security Bad Smells of Software by using Data Mining
Authors: Alraddadi Sara 
Published: March 2023

Abstract

Bad smells of code can lead to significant software vulnerabilities that negatively affect the security attribute of software and make the software easily attacked. Method implementation is the lowest code level that produces bad smells in software. Several programming guidelines have been introduced to reduce the number of bad code smells. Some are related to security, while others are related to other software quality attributes. We can detect some of these guidelines by using quality metrics (e.g., the number of lines of code and the number of parameters). This project proposes applying data mining classifiers to automatically detect security code smells and non-security code smells based on software quality metrics. We developed eight models using eight classifiers: Logistic Regression, Random Forest, XG Boost, J48, SVM, Naive Bayes, LightGBM, and Neural Network. We evaluated the eight models using several performance measurements (e.g., accuracy and confusion metrics). The results showed that it could detect the security code smell from the non-security code smell with the highest accuracy of 95\%.
Improved Nodal Harvest with Intra-Corporeal Mesentery Dissection in Laparoscopic Right Hemicolectomy: A Retrospective Study
Authors: Naseem Zainab , Ho Kah , Tran Mathew , Hapangama Nipuni , Fitzgerald Kate , Maqbool Abrar , D'Souza Basil , Hargreaves Warren , Jayachandran Narayanan 
Published: March 2023

Abstract
Background
Right-sided colon cancer is now commonly treated by laparoscopic right hemicolectomy (LRH). The best procedure for mesentery dissection and nodal harvesting is still being debated. The purpose of this research is to compare intra-corporeal mesentery dissection (ICMD) with extra-corporeal mesentery dissection (ECMD) approaches and assess their impact on nodal harvest during LRH.
Methods
A retrospective analysis of 78 operative cases of LRH was performed. The patients were divided into two groups: those with ICMD (n = 30) and those with ECMD (n = 48). The total number of lymph nodes extracted was the primary outcome. The number of positive lymph nodes, length of hospital stay, and surgical complications were some of the secondary objectives.
Results
The total number of lymph nodes extracted in the ICMD was considerably higher (p = 0.02). Cancers located in the ascending colon were associated with more lymph nodes than tumours located in the cecum or hepatic flexure (p0.001). The two groups did not differ significantly regarding the median number of positive lymph nodes or length of hospital stay.
Conclusion
This study demonstrates that ICMD provides improved nodal yield compared to ECMD in LRH for right-sided colon cancer. Tumor location also impacts the nodal yield, with tumors in the ascending colon having the highest yield. Understanding the optimal mesentery dissection technique and nodal harvest can help improve the oncological outcomes. The use of robotic surgical equipment may further enhance the ICMD approach, especially for accessing retroperitoneal structures.
A multi-omics integrative analysis based on CRISPR screens re-defines the pluripotency regulatory network in ESCs
Authors: Jian Rui , Ruan Yan , Wang Jiaqi , Yu Meng , Wang Fengsheng , Wang Jiangjun , Xu Yixiao , Liu Lianlian , Cheng Yuda , Yang Ran , Zhang Chen , Yang Yi , Wang JiaLi , Wu Wei , Chen Guangxing , Huang Yi , Tian Yanping , Zhang Junlei 
Published: March 2023

Abstract
A comprehensive and precise definition of the pluripotency gene regulatory network (PGRN) is crucial for clarifying the regulatory mechanisms in embryonic stem cells (ESCs). Here, after a CRISPR/Cas9-based functional genomics screen and integrative analysis with other functional genomes, transcriptomes, proteomes and epigenome data, an expanded pluripotency-associated gene set is obtained, and a new PGRN with nine sub-classes is constructed. By integrating the DNA binding, epigenetic modification, chromatin conformation, and RNA expression profiles, the PGRN is resolved to six functionally independent transcriptional modules (CORE, MYC, PAF, PRC, PCGF and TBX). Spatiotemporal transcriptomics reveal activated CORE/MYC/PAF module activity and repressed PRC/PCGF/TBX module activity in both mouse ESCs (mESCs) and pluripotent cells of early embryos. Moreover, this module activity pattern is found to be shared by human ESCs (hESCs) and cancers. Thus, our results provide novel insights into elucidating the molecular basis of ESC pluripotency.
The changing precipitation storm properties under future climate change
Authors: Wang Haijie , Jiang Peng , Zhang Rongrong , Zhao Jiahui , Si Wei , Fang Yong , Zhang Nana 
Published: March 2023

AbstractChanges in precipitation storm characteristics especially extreme precipitation events have been frequently reported during recent years, which poses great challenges for flood controls of reservoir basins. In this study, we present a comprehensive examination on the evolution of storm properties during two distinct rainy seasons in Changtan Reservoir Basin located on the southeastern coast of China. We compare the differences in storm duration, inter-storm period, the average storm intensity, and with-in storm pattern between the Meiyu flood season (MFS) and typhoon flood season (TFS). We also explore the future projections of these storm properties based on Coupled Model Inter-comparison Project 6 (CMIP6) precipitation outputs. Our results indicate that precipitation storms in TFS exhibit shorter duration and higher average storm intensity than those of MFS, the flood risk in June is mainly due to accumulative precipitation (longer duration), while in July to September, is mainly due to the storms with high intensity. The projected precipitation shows uncertainties for different emission scenarios, especially during TFS. However, the increasing trend of the average storm intensity is relatively consistent, which is supposed to bring more pressure on flood control in the study area. The results can provide a beneficial reference to water resources management.
Does agricultural water-saving policy improve food security? Evidence from the Yellow River Basin in China
Authors: Yang Rui , Xu Hang 
Published: March 2023

Abstract
For our empirical research, the 2012 implementation of China's National Agricultural Water-Saving Outline serves as a quasi-experiment. In addition, one of the main regions in China for grain production is the Yellow River Basin. Based on this, we utilize a Difference-in-Difference (DID) empirical technique to assess the impact of the agricultural water-saving policy on food security using data from prefectures in China's Yellow River Basin from 2000 to 2020. According to the estimated results, grain production has greatly increased as a result of the agricultural water-saving policy. This conclusion still holds when other water-related policies are considered. The agricultural water-saving policy may enhance other input factors in grain production by assuring water demand, which is one possible mechanism of the influence. The empirical results show that the policy indeed increases the water productivity in agricultural production, which will ensure the effective water utilization in agricultural production, and the grain sown area, which is the most important production factor in agriculture. In heterogeneity analysis, the impact of the policy on food security is the largest in the lower reach, followed by the middle reach and the smallest in the upper reach in the Yellow River Basin.
Possible Pathophysiological Roles of Neurotransmitter Systems in Men With Lifelong Premature Ejaculation: Protocol for a Scoping Review
Authors: Van Raaij Joost Johan , Janssen Paddy Koen Camiel 
Published: March 2023

Background
Lifelong premature ejaculation (LPE) is a rare sexual condition believed to be caused by genetic neurobiological disorders. In the field of LPE, 2 main types of research have been conducted: direct genetic research and pharmacotherapeutic interference of neurotransmitter systems that can relieve the symptoms of LPE in male patients.

Objective
We aim to provide an overview of studies on neurotransmitter systems as the pathophysiological cause of LPE by investigating direct genetic research or pharmacotherapeutic interference that relieves the main symptom of LPE in male patients.

Methods
This scoping review will use the PRISMA-ScR tool (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). In addition, this study will use a peer-reviewed search strategy. Systematic searches will be conducted using 5 scientific databases (Cochrane Database of Systematic Reviews, PubMed or MEDLINE, Cumulative Index to Nursing and Allied Health Literature [CINAHL], EMBASE, and Epistemonikos). Additionally, pragmatic searches for relevant information in gray literature databases will be performed. Two reviewers will independently include relevant studies in a 2-stage selection strategy. Finally, data will be extracted from the studies and charted to summarize relevant study characteristics and key findings.

Results
As of July 2022, we completed the preliminary searches according to the PRESS 2015 guidelines and started to determine the final search terms that we will use in all selected 5 scientific databases.

Conclusions
This scoping review protocol is the first to focus on neurotransmitter pathways in LPE by combining the results from the genetic and pharmacotherapy studies. The results could help identify potential research gaps or target candidate proteins and neurotransmitter pathways in LPE for further genetic research.

Trial Registration
Open Science Framework 10.17605/OSF.IO/JUQSD; https://osf.io/juqsd

International Registered Report Identifier (IRRID)
PRR1-10.2196/41301
The Change in Exergaming From Before to During the COVID-19 Pandemic Among Young Adults: Longitudinal Study
Authors: O'Loughlin Erin K , Sabiston Catherine M , O'Rourke Roxy H , Bélanger Mathieu , Sylvestre Marie-Pierre , O'Loughlin Jennifer L 
Published: March 2023

Background
Exergaming may be an important option to support an active lifestyle, especially during pandemics.

Objective
Our objectives were (1) to explore whether change in exergaming status (stopped, started or sustained exergaming, or never exergamed) from before to during the COVID-19 pandemic was related to changes in walking, moderate-to-vigorous physical activity (MVPA) or meeting MVPA guidelines and (2) to describe changes among past-year exergamers in minutes per week exergaming from before to during the pandemic.

Methods
A total of 681 participants (mean age 33.6; SD 0.5 years; n=280, 41% male) from the 22-year Nicotine Dependence in Teens (NDIT) study provided data on walking, MVPA, and exergaming before (2017 to 2020) and during (2021) the COVID-19 pandemic. Physical activity (PA) change scores were described by change in exergaming status.

Results
We found that 62.4% (n=425) of the 681 participants never exergamed, 8.2% (n=56) started exergaming during the pandemic, 19.7% (n=134) stopped exergaming, and 9.7% (n=66) sustained exergaming. Declines were observed in all 3 PA indicators in all 4 exergaming groups. The more salient findings were that (1) participants who started exergaming during COVID-19 reported the highest MVPA levels before and during the pandemic and declined the least (mean –35 minutes/week), (2) sustained exergamers reported the lowest MVPA levels during the pandemic (median 66 minutes/week) and declined the most in MVPA (mean change of –92 minutes/week) and in meeting MVPA guidelines (–23.6%). During the pandemic, starting exergamers reported 85 minutes of exergaming per week and sustained exergamers increased exergaming by a median 60 minutes per week.

Conclusions
Although starting and sustaining exergaming did not appear to help exergamers maintain prepandemic PA levels, exergaming can contribute a substantial proportion of total PA in young adults and may still represent a useful option to promote PA during pandemics.
Out of Adversity Comes Opportunity: Smart-Colpo National Program for the Elimination of Carcinoma Cervix in a Post–COVID-19 World
Authors: R Anjali , Gowda Naveen R , H Vikas , Prabhu Meghana , Sharma Jai Bhagwan , Vakharia Khyati , Kumar Atul , M V Akhila , Gatta Shilpa , Sareddy Madhuri , K P Sowmya , T K Divya , Desai Devashish , Gopinath Bharath , Viswanath Somanath , Kini Ananth 
Published: March 2023

Background
Carcinoma cervix is one of the leading causes of death among women worldwide. The World Health Organization has put forth the 90-70-90 global strategy for the elimination of cervical cancer as a public health problem. It calls for 70% women to be screened at least once in their lifetime. However, this rate is as low as 1.9% for India and even lower for many other countries, making the target insurmountable, especially in resource-constrained settings. The COVID-19 pandemic made this even more challenging.

Objective
This study aimed to identify bottlenecks and high leverage points and propose a technology-driven, national-level program for improving the screening of carcinoma cervix.

Methods
Detailed process mapping was done to identify potential bottlenecks. A counterfactual approach was used to identify high leverage points for impact using “What if” scenarios. These findings were used to build program theory–based logic models to propose a national-level program for carcinoma cervix prevention.

Results
Availability, accessibility, affordability, skewed distribution of infrastructure, cost implications, and limited specialist workforce were identified as bottlenecks. The COVID-19 pandemic put a strain on existing resources and worsened the situation. The existing network of primary health care workers, changes in health-seeking behavior due to COVID-19 with the increasing role of tele-health, conducive political milieu with initiatives such as Digital India Mission, and a booming start-up ecosystem were identified as high leverage points through the counterfactual approach. Using these findings, a national program was designed with program theory–based logic modeling.

Conclusions
The journey from <2% of women screened at least once in their lifetime all the way to 70% would need a drastic increase in funding and resource allocation, which is unlikely considering the current conditions. COVID-19 has not only been an adversity but also opened new thinking and opportunities. Artificial intelligence–driven, cost-effective, easy-to-use, and widely acceptable solutions such as “Smart-Colpo” can be a game changer to achieve the World Health Organization targets.

Conflicts of Interest
None declared.
Comportamiento del Strain ventrículo derecho en pacientes tratados con quimioterapia y/o radioterapia en una cohorte de pacientes
Authors: Canahuate Rodríguez Grisel , Taveras Hiraldo Amparo , Rivera Núñez Eleana , Pérez Alegría Saray , Arias Ceballos Miguel 
Published: March 2023

Introducción: es bien conocida la utilidad del strain global longitudinal (SGL) del ventrículo izquierdo (VI) en pacientes que reciben antineoplásicos. Estudios recientes sugieren una conducta similar del strain longitudinal de la pared libre (SLPL) del ventrículo derecho (VD), pero en la literatura aún existen muchas controversias que limitan su valoración, por lo que este estudio es un aporte a esta necesidad de practicidad.
Objetivo: evaluar el comportamiento del SLPL del VD en los pacientes tratados con quimioterapia y/o radioterapia, y su correlación con el SGL del VI.
Metodología: se aplicó un protocolo de recolección de datos que incluía variables demográficas y antecedentes de pacientes con diagnóstico de cáncer, tratados con quimioterapia y/o radioterapia, que acudieron a realizarse un ecocardiograma con strain, desde noviembre 2020 a marzo 2021. El ecocardiograma se hizo acorde con los estándares de las guías de la Sociedad Americana de Ecocardiografía, que incluyera SGL del VI y el SLPL del VD. Los datos fueron analizados en programa SPSS.
Resultados: de 90 pacientes, 6 excluidos para un total de 84 recopilados. 89 % mujeres, edad promedio 59 ±11 años, 73 % cáncer de mama. 54 % hipertensos, 27 % obesos, 23 % con dislipidemia, 19 % diabéticos y 11 % eran o fueron fumadores. 46 % había recibido quimioterapia y radioterapia concomitantes y el 48 % había recibido tratamiento hace más de un año. En hallazgos ecocardiográficos: fracción de eyección del VI (FE) promedio 64±7; sin embargo, 82 % tenía SGL del VI reducido (44 % menor a -15 %). De manera similar, el 74 % tenía reducción del SLPL del VD, pero solo el 15 % de la onda S del Doppler tisular del VD estaba anormal, 7 % del TAPSE estaba reducido y 6 % el cambio del área fraccional (CAF). El coeficiente de correlación de Pearson entre el SGL del VI y el SLPL del VD fue de 0.463, con un valor de p <.001, indicando una significativa relación lineal positiva moderada.
Conclusión: nuestro estudio sugiere que el SLPL del VD tiene un comportamiento similar al SGL del VI y es un mejor predictor de disfunción ventricular derecha, por encima de los parámetros convencionales. Por esta razón, debería incorporarse como una medida rutinaria en la evaluación ecocardiográfica de los pacientes que reciben terapias antineoplásicas.
Síndrome de Guillain Barré asociado a infección por SARS-CoV-2: a propósito de un caso
Authors: Ortiz Isi , Acevedo Noemí , Fernández Alina , Santana Genara , Martínez Anyelina 
Published: March 2023

Introducción: la pandemia de SARS-CoV-2 exige una medicina fiable, basada en evidencia para poder comprender y tratar oportunamente las nuevas manifestaciones de esta enfermedad, previniendo así las complicaciones y la mortalidad infantil.
Materiales y método: femenina de seis años ingresada en urgencias con síntomas neurológicos de entumecimiento en extremidades inferiores y superiores, ataxia, somnolencia y disartria. Después de un análisis de sangre, un examen del líquido cefalorraquídeo y una prueba de electromiografía, la paciente fue diagnosticada con síndrome de Guillain-Barré e infección concomitante por COVID-19.
Resultados y discusión: se obtuvieron resultados positivos, tanto para el anticuerpo IgM como para la RT-PCR, para infección por SARS-CoV-2. No se encontró evidencia de celularidad en el examen del líquido cefalorraquídeo, pero se observó un alto nivel de proteína de 100 mg/dL y un nivel anormal de glucosa (58 mg/dL) en este paciente. Por último, se administró una terapia consistente en dexametasona 3,5 mg/kg, paracetamol 315 mg/kg, azitromicina 105 mg/kg y 50 mg/kg de inmunoglobulina intravenosa.
Conclusión: considerando este caso clínico, reforzamos la hipótesis de la asociación entre el síndrome de Guillain-Barré y la infección por el virus SARS-CoV-2, como ya han documentado otros autores, tanto en adultos como en pacientes pediátricos.
Dietary nitrate and corresponding gut microbiota prevent cardiac dysfunction in obese mice
Authors: Petrick Heather L. , Ogilvie Leslie M. , Brunetta Henver S. , Robinson Avery , Kirsh Aleah J. , Barbeau Pierre-Andre , Handy Rachel M. , Coyle-Asbil Bridget , Gianetto-Hill Connor , Dennis Kaitlyn M.J.H. , Loon Luc J.C. van , Chabowski Adrian , Schertzer Jonathan D. , Allen-Vercoe Emma , Simpson Jeremy A. , Holloway Graham P. 
Published: March 2023

<p>Impaired heart function can develop in diabetic individuals in the absence of coronary artery disease or hypertension, suggesting mechanisms beyond hypertension/increased afterload contribute to diabetic cardiomyopathy. Identifying therapeutic approaches that improve glycemia and prevent cardiovascular disease are clearly required for clinical management of diabetes-related comorbidities. Since intestinal bacteria are important for metabolism of nitrate, we examined if dietary nitrate and fecal microbial transplantation (FMT) from nitrate-fed mice could prevent high-fat diet (HFD)-induced cardiac abnormalities. Male C57Bl/6N mice were fed an 8-week low-fat diet (LFD), HFD, or HFD+Nitrate (4mM sodium nitrate). HFD-fed mice presented with pathological left ventricular (LV) hypertrophy, reduced stroke volume and increased end diastolic pressure, in association with increased myocardial fibrosis, glucose intolerance, adipose inflammation, serum lipids, LV mitochondrial reactive oxygen species (ROS), and gut dysbiosis. In contrast, dietary nitrate attenuated these detriments. In HFD-fed mice, FMT from HFD+Nitrate donors did not influence serum nitrate, blood pressure, adipose inflammation, or myocardial fibrosis. However, microbiota from HFD+Nitrate mice decreased serum lipids, LV ROS, and similar to FMT from LFD donors, prevented glucose intolerance and cardiac morphology changes. Therefore, the cardioprotective effects of nitrate are not dependent on reducing blood pressure, but rather mitigating gut dysbiosis, highlighting a nitrate-gut-heart axis. </p>
The Nordic Dimension as a Metaspace for Educational Research
Authors: Krejsler John Benedicto 
Published: March 2023

The article argues that observing ‘the Nordic dimension’ as a metaspace in methodological terms harbors rich potential for qualifying educational research, policy, and debate. The metaspace gathers critical mass through aggregating the potential of smaller spaces. The five Nordic countries thus represent historical, linguistic, and societal similarities that produced similar societal and educational values, albeit along different trajectories. Understood as a floating signifier in scalar and topological terms, the Nordic dimension allows researchers and others to draw on the diversity that this metaspace represents as a tool for rethinking national solutions. The article draws on educational research and literature with a Nordic focus.