bluuebunny/crossref_metadata_2025_split huggingface dataset:
Black mulberry (Morus nigra L.) fruits: As a medicinal plant rich in human health-promoting compounds
Authors: Sakar Ebru , Ercisli Sezai , Marc Romina Alina , Gulen Hatice , Assouguem Amine , Ullah Riaz , Shahat Abdelaaty A. , Bari Ahmed , Farah Abdellah 
Published: May 2023

Abstract

Morus nigra, black mulberry, is the most attractive among mulberry species. The study aimed to determine human health-promoting content and antifungal activity in fruits of seven black mulberry genotypes grown in the Tortum district of Turkey. The genotypes exhibited significant differences in most of the human health-promoting content. Among individual sugars and organic acids, glucose (6.98–8.03 g/100 g fresh weight base) and malic acid (6.33–10.45 g/100 g fresh weight base) were predominant. The ascorbic acid content of genotypes was found between 18.13 and 26.77 mg/100 g fresh weight base, indicating that black mulberry fruits had moderate ascorbic acid content. Total phenolic content, total antioxidant capacity, and total anthocyanin contents in fruit extracts of seven black mulberry genotypes were also investigated. The results showed that the levels of the aforementioned parameters changed depending on genotypes. The total phenolic and total anthocyanin contents were in the range of 1,656–2,348 μg gallic acid equivalent (GAE)/g and 623–804 μg C3GE (cyanidin-3-glucoside equivalent)/g, respectively. The genotypes had antioxidant capacity between 17.41 and 3.86 μg/mL and between 10.08 and 14.11 μmol TE/g measured by the 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power assay, respectively. Some of the genotypes (TOR-1 and TOR-2) had high antifungal activity particularly against C. albicans. It was determined that the people living in the region traditionally use mulberries as blood enhancer, immune system booster, and mouth lesion treatments to protect themselves against different types of cancers and against inflammation. The present results confirm that attractive fruits of black mulberry are a rich natural source of phenolic antioxidants and can contribute to the dietary intake of antioxidants, depending on genotypes.
Perspective-taking and intersubjectivity in oral narratives of people with a schizophrenia diagnosis: a cognitive linguistic viewpoint analysis
Authors: van Schuppen S. Linde , van Krieken Kobie , Claassen Simon A. , Sanders José 
Published: May 2023

Abstract
Disruptions in theory of mind faculties and the ability to relate to an intersubjective reality are widely thought to be crucial to schizophrenic symptomology. This paper applies a cognitive linguistic framework to analyze spontaneous perspective-taking in two corpora of stories told by people with a schizophrenia diagnosis. We elicited natural narrative language use through life story interviews and a guided storytelling task and analyzed the linguistic construal of viewpoint in these stories. For this analysis, we developed a reliable and widely applicable viewpoint model that allows for the categorization and quantification of speakers’ linguistic presentation and navigation of spatiotemporal domains. We found that our participants skillfully presented, navigated and embedded different narrative viewpoints through a variety of linguistic viewpoint devices. They presented complex viewpoints of other people in both the here-and-now of the interaction and the there-and-then of a narrative, and made use of transition markers to demarcate spatiotemporal discourse domains. We found no differences in viewpoint variables when comparing their guided stories to a control group. If problems with intersubjectivity are indeed an essential part of schizophrenia, an explanation of how this group can take on and navigate complex linguistic viewpoints in natural narrative interaction is called for.
From “screen time” to screen times: Measuring the temporality of media use in the messy reality of family life
Authors: Mascheroni Giovanna , Zaffaroni Lorenzo Giuseppe 
Published: May 2023

Abstract
The discrepancy between children’s actual amount of viewing time and parents’ accounts of their concerns, rules, and parental mediation choices has been documented in empirical research, and typically interpreted through the lens of the Uses and Gratifications theory – showing how parents change their attitudes towards screen media in order to satisfy their own needs. Based on a qualitative longitudinal research project, including app-based media diaries, with 20 families with at least one child aged eight or younger, we aim to make two contributions to the literature. With regard to theory, we aim to highlight the heterogeneous and contingent ways of balancing the place of digital media in children’s lives that arise from parents navigating screen time discourses, social pressures, and daily schedules. With regard to methods, we argue for the combination of qualitative data and app-based media diaries to contextualise and interpret potential discrepancies between reported screen time and parental anxieties or hopes about digital media.
How Does Entrepreneurial Role Model Connect to Entrepreneurial Perceptions: The Moderating Role of Psychological Distance
Authors: Zhao Haiyuan , Jiang Hui , Fang Qinyi , Weng Qingxiong 
Published: May 2023

Abstract
The influence of entrepreneurial role models on individuals could be regarded as a social learning process. However, we still lack an in-depth understanding of under what conditions the impacts of entrepreneurial role models are stronger or weaker. This paper draws on social learning theory and construal level theory to explore how entrepreneurial role models relate to individuals’ entrepreneurial perceptions under different psychological distance dimensions. A representative sample of 322 final-year students from nine universities in China was analyzed. The results demonstrated that entrepreneurial role model was positively associated with feasibility and desirability perceptions. Further, we found that the spatial distance and social distance as boundary conditions, respectively, moderated the main effects. This study extends prior research on the functions of entrepreneurial role model by providing a psychological distance perspective.
PQ event identification in PV-wind based distribution network with variational mode decomposition and novel feature enabled random forest classifier
Authors: Mishra Sairam , Nayak Pravati , Mallick Ranjan Kumar , Gadanayak Debadatta A. , Panda Gayadhar 
Published: May 2023

Abstract
The complexity raised due to the exponential growth of renewable power generators in modern power system evokes the necessity of detecting the potential power quality threats. With this context, the article proposes a novel power quality (PQ) detection method in PV and wind generator integrated distribution networks. In the first stage, the variational mode decomposition (VMD) technique is utilized to pull out the characteristic modes out of the voltage signal for nine different PQ events. In the later stage, a set of features are extracted from the decomposed signal to train a novel Feature Enabled Random Forest Classifier (FERFC). The feature enabling capability of Random Forest classifier is reckoned with the help of a single decision tree. It has been proved that the proposed novel VMD-FERFC has the ability to accurately identify and classify the PQ disturbances in the PV-wind-based distribution network. The performance of the suggested technique is verified in presence of noise. Further the supremacy of the method is established by comparing with other competitive reported PQ detection methods.
Performance enhancement of passive optical network with improved bandwidth utilisation and allocation
Authors: Sharma Vikas , Sharma Sharad 
Published: May 2023

Abstract
In the past decade optical network is growing very rapidly due to the low noise, less bit error rate as well as bandwidth utilization of the network. In this paper explored the bandwidth utilization with the improved gain with less noise and low bit error rate. Previously worked had been done on this area up to the 2nd stage of the optical networks. Previous worked explain the utilization of the bandwidth also explore the allocation of bandwidth in between the two different networks. They also find out the different optimized parameters like bit error rate, delay, gain, and low noise using different methods. But this paper explored up to the fifth stage of the optical network with the optimum parameters has been found out after the simulation. It also explains the bandwidth reuse to the next level of the optical network without any delay provided in between the two consecutive stages. In this explored the future prospective of the next generation optical network and also explain the different module of the stages.
Acquired idiopathic isolated ACTH deficiency with associated autoimmune thyroiditis in pediatrics: case report and review of the literature
Authors: Giannakopoulos Aristeidis , Efthymiadou Alexandra , Chrysis Dionisios 
Published: May 2023

Abstract

Objectives
Isolated ACTH deficiency (IAD) is defined as an impaired secretion of ACTH from the pituitary gland without any other anterior pituitary hormonal deficits. The idiopathic form of IAD has been described mainly in adults and is thought to be caused by an autoimmune mechanism.

Case presentation
Herein, we present an 11-year-old _prepubertal previously healthy boy, who suffered a severe hypoglycemic episode short after the initiation of thyroxine for autoimmune thyroiditis and was finally diagnosed with secondary adrenal failure due to idiopathic IAD, after all other etiologies were excluded, thought an extensive diagnostic work-up.

Conclusions
Idiopathic IAD is a rare entity of adrenal insufficiency in pediatrics that should be considered as an etiology of secondary adrenal failure in children, when clinical signs of glucocorticoid deficiency are present and other causes are excluded.
Solution-processed Bi2S3/BiVO4/TiO2 ternary heterojunction photoanode with enhanced photoelectrochemical performance
Authors: Li Xinli , Wang Sha , Wang Kunjie , Yang Jiachen , Wang Kexuan , Han Chao , Li Lihua , Yu Renhong , Zhang Yong 
Published: May 2023

Abstract
TiO2 is an important component of photoelectric devices. How to broaden the light absorption of TiO2 and accelerate the separation of photo-generated electrons and holes is the focus of the current research. Building heterojunction with narrow band gap semiconductor and TiO2 is one of the important measures to improve its photoelectric performance. We prepared BiVO4/TiO2 binary heterojunction by the simple hydrothermal method and analyzed the effect of BiVO4 precursor solution concentration on the microstructure and photoelectric performance of the heterojunction. BiVO4/TiO2 binary heterojunction can effectively improve the photoelectric performance of TiO2, and the transient current density reaches 85 μA/cm2. To further boost the photocurrent of BiVO4/TiO2, Bi2S3 was in situ grown on the heterojunction to form Bi2S3/BiVO4/TiO2 ternary heterojunction. The results show that the band gap of Bi2S3/BiVO4/TiO2 composites is significantly narrowed compared with that of TiO2. The light absorption has been expanded to the visible range, and the photogenerated current density is also greatly boosted (0.514 mA/cm2). This Bi2S3/BiVO4/TiO2 ternary heterojunction accelerates the separation of photo-carriers and improves the photoelectric performance of the device. The possible transport mechanism of photo-carriers in ternary heterojunction is analyzed. The current study provides an effective strategy for in situ construction of novel multicomponent heterojunction and provides a basis for the application of Bi2S3/BiVO4/TiO2 in the optoelectronic field.
Anemarrhenasaponin I suppresses ovarian cancer progression via inhibition of SHH signaling pathway
Authors: Deng Simin , Xu Yuan , Gao Binbin , Yu Tingting , Kuang Lun , Han Bo’ang , Feng Shaolun , Chi Haodong , Cao Qing , Yue Shen , Liu Chen 
Published: May 2023

Abstract

Objectives
The Sonic hedgehog (SHH) signaling is essential in animal development and tissue homeostasis. Aberrant activation of SHH pathway has been implicated in tumorigenesis and progression of several cancers, including ovarian cancer. Therefore, targeting SHH pathway may pave the way for successful ovarian cancer treatment.

Methods
To identify the potential SHH inhibitors from traditional Chinese medicines, we herein employed two in vitro cell models. In addition, western blotting and quantitative real-time PCR were performed to evaluate the inhibitory activity of Anemarrhenasaponin I (An-I) on SHH signaling in ovarian cancer cells. Cell proliferation assay and transwell assay were used to assess the effect of An-I on tumorigenicity. We also applied RNA-seq to examine the potential mechanism of An-I against ovarian cancer.

Results
Drug screening results showed that An-I drastically inhibited SHH signaling. More importantly, An-I effectively suppressed ovarian cancer cell proliferation and aggressiveness. RNA-seq-based transcriptome data showed that An-I affected ovarian cancer cells by suppressing SHH-WNT-Matrix metalloproteinases (MMPs) pathway.

Conclusions
An-I suppressed ovarian cancer progression by inhibiting SHH-WNT-MMP signaling transduction, providing a new treatment strategy for ovarian cancer.
Effects of stress response induced by laparoscopic colectomy and laparotomy on TLR-mediated innate immune responses in colon cancer patients
Authors: Cui Qingfeng , Li Lei , Hu YongJun , Wang Fang , Zhang Chan , Li Change 
Published: May 2023

Abstract

Objectives
Colon cancer patients were analyzed to compare the effects of surgical trauma on immune function by detecting the activation degree of cell inflammatory cytokines levels after different surgical procedures.

Methods
In total, 107 patients with colon cancer were divided into open surgery group and laparoscopic surgery group. Serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14) and myeloid differentiation protein-2 (MD-2) levels were detected before, after and one day after surgery.

Results
Serum CRP, IL-6 and TNF-α levels in both groups were significantly increased at all postoperative time points after surgery compared with those preoperatively. CRP, IL-6 and TNF-α levels in the laparoscopic group were lower than that in the open surgery group at all time points after surgery. Serum IL-6 and TNF-α levels in open surgery group were significantly lower than those in the laparoscopic surgery group after LPS stimulation. Laparoscopic surgery led to the decrease of serum CD14, TLR4 and MD-2 levels. The incidence of postoperative complications in laparoscopic group was significantly less as compared to the open surgery group.

Conclusions
Cellular immunity may be better presented after laparoscopic surgery in comparison with open surgery. Laparoscopic complete mesenteric resection surgery is effective in the treatment of colon cancer.
Experience of patients with metastatic breast cancer in France: results of the 2021 RÉALITÉS survey and comparison with 2015 results
Authors: Frenel Jean-Sébastien , Guiu Séverine , Guéroult-Accolas Laure , Zernik Nicole , Lefeuvre-Plesse Claudia , Moley-Massol Isabelle 
Published: May 2023

Abstract

Objectives
Metastatic breast cancer (MBC) and its treatments can significantly impact patient quality of life (QoL). In 2015, the RÉALITÉS 1 study documented the disease experience of 230 French patients. The objective of RÉALITÉS 2 was to analyse the evolution of QoL and the management of patients with MBC five years later.

Methods
Between September 2020 and February 2021, 266 patients with MBC completed a self-administered questionnaire on their understanding of their disease, its treatments and their impact on QoL.

Results
Compared to 2015, patients had better knowledge of the metastatic status of their cancer (76 vs. 65%, p<0.01) and of treatment-related adverse events (81 vs. 71%, p<0.05). They felt that their oncologist listened to them more (78 vs. 68%, p<0.01) and were more likely to feel good when taking their treatment (73 vs. 60%, p<0.01). Although the use of certain supportive care increased, such as social assistance (36 vs. 26%, p<0.05) and aesthetic advice (26 vs. 16%, p<0.01), 44% of patients still did not make use of it. Anxiety (67% of patients in 2020–21) still has a major impact on the mental health of patients.

Conclusions
While many aspects of the QoL and management of patients with MBC have improved since 2015, there are still areas for improvement, such as access to supportive care and managing the impact of the psychological burden of the disease, for which different solutions may be considered.
If You Have Faith, Exu Responds on-line: The Day-to-Day Life of Quimbanda on Social Networks
Authors: Bahia Joana , Nogueira Farlen de Jesus 
Published: May 2023

AbstractThe present work analyzes the interface between Quimbanda and the digital environment in the daily life of a Quimbandeiro. Quimbanda is an Afro-Brazilian faith that has grown in the virtual universe through consultations and other uses of digital media. In addition to analyzing the Facebook, WhatsApp, and Instagram pages of these religious groups, we interviewed and followed the daily life of a teacher and also conducted bibliographic research on the subject. In their daily practices, Quimbandeiros use the internet as a space for interaction, quotidian practices of care, and the manufacture of spells. We analyze how digital interaction presents this religious belief in the virtual public sphere and the interconnections between religious and technological narratives. Quimbanda, a somewhat stigmatized religion, expands its boundaries in virtual mode. In the case analyzed in this article, Quimbandeiro work is directly linked to the movements of Exu, the entity who controls the crossroads. Through the mediation of the production of religious images, Exu expands his spiritual and technological presence offline, flooding online communities with meaning.
Identification of novel inhibitors of P13K/AKT pathways: an integrated in-silico study towards the development of a new therapeutic agent against ovarian cancer
Authors: Adedotun Ibrahim Olaide , Abdul-Hammed Misbaudeen , Egunjobi Basirat Temidayo , Ismail Ubeydat Temitope , Yusuf Jemilat Yetunde , Afolabi Tolulope Irapada , Gbadebo Ibrahim Olajide 
Published: May 2023

Abstract
Ovarian cancer is a crucial gynaecological unmet medical disease with a high mortality rate. According to recent research, the phosphoinositol 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways are hyper-activated in the majority of ovarian cancer patients, necessitating the use of inhibitors. Over the years, phytochemicals have been used as alternative sources of therapeutic agents due to their reported biological activities and limited side effects. Curcuma longa (Tumeric), a reported ayurvedic medicine has also been noted for its anti-cancer properties. Thus, 155 phytochemicals from this plant and 2 reference drugs were evaluated for their inhibitory prowess against P13K/AKT receptor using a computer-aided drug design approach. The binding scores and inhibiting efficiencies were obtained via virtual screening. Molinspiration Chemoinformatics and SwissADME tools were used to investigate the drug-likeness properties and oral bioavailability of the compounds selected, while the ADMET SAR-2 website was used to conduct the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) analysis. Other analyses performed on the selected compounds include bioactivity, activity spectra for substances (PASS) prediction, binding mode, and molecular interaction. The results revealed that Hopenone 1 (−8.8 kcal mol−1) and Epriprocurcumenol (−7.8 kcal mol−1) are potent inhibitors of the P13K receptor, while Epiprocurcumenol (−9.0 kcal mol−1), Procurcuminol (−8.6 kcal mol−1) and Curlone (−8.3 kcal mol−1) are potential inhibitors of AKT receptor. In comparison to Topotecan and Melphalan, they have better binding affinities, oral bioavailability, drug-likeness characteristics, ADMET properties, bioactivities, PASS properties, binding mechanism, and also interact well with the active site of the target receptor. As a result, this preliminary investigation suggests that these chemicals should be studied further for the design of novel ovarian cancer therapeutics.
Carnet Japon avril 2015
Authors: Sauvagnargues Anne 
Published: May 2023

O ensaio visual do Dossiê Deleuze: Modos de Usar apresenta pinturas da artista e filósofa francês Anne Sauvagnargues que compõem seu Carnet Japon avril 2015, uma coleção de imagens capturadas em seu cotidiano de deslocamentos no transporte público. O ensaio inicia com uma apresentação de Lilian Hack. Japan April 2015 notebookAbstract: The visual essay which is part of the Dossiê Deleuze: Modes of Use features paintings by the French artist and philosopher Anne Sauvagnargues who composed her Carnet Japon avril 2015 (Japan April 2015 notebook) from a collection of images captured in her daily commute using public transport. The essay begins with a presentation by Lilian Hack.
The relationship between mental fatigue, depression, and cognition in Graves’ disease
Authors: Johansson Birgitta , Holmberg Mats , Skau Simon , Malmgren Helge , Filipsson Nyström Helena 
Published: May 2023

Objective
Mental fatigue, depression, anxiety, and cognitive complaints are common in Graves’ disease (GD). Our aims were to assess the relationship between these variables in patients with GD during both hyperthyroidism and a long stable euthyroidism.

Methods
A prospective longitudinal case-control study where 65 premenopausal women diagnosed with GD and 65 matched controls were assessed twice with 15 months in between. The first visit for patients was in overt hyperthyroidism and the second after treatment.

Results
During the hyperthyroid phase, mental fatigue, depression, and anxiety were significantly increased for GD patients compared to controls (all P < 0.001). Among GD patients, 89% reported mental fatigue and among controls 14%. No difference in cognitive tests was found. After 15 months, significant improvements for GD patients after treatment were found for the items of mental fatigue, depression, and anxiety (all P < 0.001), but these were unchanged in controls. GD patients reported residual mental fatigue (38%), 23% without depression, and 15% mental fatigue combined with depression. Self-reported cognitive complaints were pronounced while cognitive tests did not reveal any deficiencies.

Conclusion
Mental fatigue and emotional distress are common in the hyperthyroid phase. These improve with treatment but are still more common in GD patients after 15 months of therapy than in controls. The residual mental fatigue is shown to be a phenomenon distinct from depression in this study. This indicates the importance of assessing mental fatigue in GD patients and underlines the need for rehabilitation and healthcare support as fatigue will have consequences for work ability.
Un aspetto dell'intelligence nel mondo greco: la parola d'ordine
Authors: Santagati Elena 
Published: May 2023

AbstractIn the ancient world, visual and verbal σύνθημα appears to be of enormous importance during conflicts. It is one of the elements pertaining to the management and organization of political intelligence. In particular, the signal, declined in the verbal form, for its fundamental function of ‘recognition’ to validate the belonging of a soldier to a particular side, had to be chosen with great care. Its use appears to have intensified and, at the same time, perfected, according to what can be gathered from historiographical evidence and from military treatises, at the time of the transition between the Classical and Hellenistic eras, when the way of waging war also underwent an important transformation.