bluuebunny/crossref_metadata_2025_split huggingface dataset:
« Îles dans l’île », groupe à médiation en situation transculturelle : les défis de la prise en charge des jeunes migrants
Authors: Alfano Pietro 
Published: December 2022

À travers le recours à la médiation photographique, nous souhaitons montrer les bénéfices du recours à un dispositif groupal à médiation dans le contexte migratoire. Sur ce fond instable, nous rencontrons des configurations identitaires et psychiques vulnérables, exposées aux risques d’un traumatisme psychique. Ce qui apparaît à contre-jour, c’est un tissu de relations imprégné de violence structurelle qui prend souvent le langage de la violence symbolique, pour utiliser un concept cher à Bourdieu : dans le pays d’arrivée, même dans le « lieu » dont nous nous sommes garants, celui de la relation d’aide, peuvent se reproduire des formes de violence subies avec une intensité très différente dans les contextes d’origine et pendant le processus migratoire. Nous souhaitons mettre en évidence la pertinence du travail de l’anthropologue E. De Martino concernant les apocalypses culturelles et la « crise de la présence » liée à la migration afin de penser à un processus d’insertion dans une communauté capable d’accueillir la crise, en l’élaborant dans une dynamique sociale vivante.
Les associations et les institutions du médicosocial
Authors: Voiturier Jérôme 
Published: December 2022

L’histoire de la Sécurité sociale, et plus largement celle des politiques sociales, est, pour reprendre l’expression de Colette Bec 1 « intimement liée à la démocratie » . Les associations sont des espaces de vitalité et d’expérimentation démocratique sans égal. Il est donc évident que les politiques sociales ne peuvent se faire sans le dynamisme associatif ; d’autant plus qu’avant la création de la Sécurité sociale le rôle du tiers secteur dans la prise en charge de l’exclusion aux différents risques sociaux était prépondérant. Témoins et acteurs des grandes questions qui ont traversé le xx e siècle et le début du xxi e siècle, les associations médicosociales et sociales accueillent, hébergent, accompagnent, défendent, représentent les personnes vulnérables. Ainsi, les grandes associations « historiques » se sont constituées dans la première moitié du xx e siècle afin de répondre à l’absence de prise en charge et d’accompagnement des pouvoirs publics en créant des structures, des établissements, des services, et ainsi combattre la mise au ban, l’isolement des personnes et le dénuement des familles sans solution. Puis, en écho à l’évolution de la société et à la volonté d’une plus forte égalité de la seconde moitié du siècle précédent, les associations médicosociales et sociales se font fait les porte-parole de l’exigence des droits des exclus, en plaidant pour une ouverture de la société dite « ordinaire » dans une perspective de société plus « inclusive ».
La guerre cyber en Ukraine
Authors: Vallée Pierre 
Published: December 2022

Après plus de huit mois d’affrontements, les analystes continuent de s’interroger sur la relative absence du cyberespace dans la guerre en Ukraine. Alors que la Russie semblait avoir démontré – à plusieurs reprises – son savoir-faire en termes d’actions cyber-offensives, sa retenue dans ce conflit surprend et conduit à questionner la réalité de ses capacités. Si l’Ukraine faisait figure de terrain d’entraînement privilégié pour les cyber-hacktivistes russes, aucun « Pearl Harbor cyber » n’est survenu après l’invasion du 24 février. Cependant, cette absence peut également s’expliquer par la résilience des défenses numériques ukrainiennes. Si Kiev les a considérablement améliorées depuis 2014 – avec le concours de ses alliées –, elle profite aussi des caractéristiques particulières du cyberespace pour lever une armée numérique transnationale afin de rééquilibrer les rapports de force dans ce milieu.
Les interactions entre la guerre en Ukraine et le Caucase du Sud
Authors: Minassian Gaïdz 
Published: December 2022

Tandis que la Russie attaque l’Ukraine, la Turquie délègue à l’Azerbaïdjan une guerre d’invasion de l’Arménie. Dans les deux cas, l’Europe assiste à une poussée du monde post-occidental en son sein. Mais à y regarder de plus près, le conflit entre l’Arménie et l’Azerbaïdjan constitue-t-il une extension de la guerre en Ukraine ou un laboratoire des convergences entre les positions russes et occidentales dans cette région sensible du monde ? Le Caucase du Sud traverse depuis 2020 son troisième âge du désenclavement depuis la chute de l’URSS en 1991 et s’interroge sur son avenir : qui dominera cet espace dans les années à venir ?
Père, mère, semblables et différents
Authors: Garnier Anne-Marie , Mosca Francesca 
Published: December 2022

Dans cet article, nous interrogeons les représentations des différences entre les rôles paternels et maternels. Sur quoi se fondent-elles ? La biologie suffit-elle à les expliquer ? Dans notre introduction, nous évoquons quelques éléments de l’évolution de nos sociétés, de la puissance paternelle à la coparentalité, et abordons ensuite les notions d’équité, d’égalité et de justice, notions traitées dans le champ de la philosophie, et dans le champ systémique, tout particulièrement par Iván Boszormenyi-Nagy. Ensuite, à l’aide de nombreux exemples cliniques ainsi que de quelques exemples tirés de la littérature, nous étudions la façon dont la répartition des tâches parentales peut affecter, souvent lourdement, les différents membres du système familial. Comment aider les familles à développer leurs propres modèles sans leur imposer les nôtres, comment soutenir le dialogue entre les parents ? Penser avec eux la symétrie ET la complémentarité des tâches parentales pourrait bien être un levier thérapeutique.
Demographic and Clinical Characteristics of 600 Children With Nystagmus
Authors: Hertle Richard W. , Evliyaoglu Ferhat , McRitchie Bayley 
Published: December 2022

Purpose:
To characterize a large, international cohort of children with nystagmus.

Methods:
Data were collected from a single-center, prospectively developed database on patients with nystagmus. Outcome variables for this study included: (1) demographic characteristics, (2) nystagmus type, (3) clinical characteristics, (4) associated ophthalmic conditions, (5) associated non-ophthalmic conditions, (6) special testing findings, and (7) treatments.

Results:
Six hundred patients from 38 states and 30 countries were included. Age ranged from birth to younger than 18 years (mean: 15.2 years), 58% were female, 55% were race other than White, 75% had infantile nystagmus syndrome, 17% had neurologically significant nystagmus, 7% had fusion maldevelopment nystagmus syndrome, 64% had strabismus, 56% had an anomalous head posture, 94% had a significant refractive error, 64% had an associated ophthalmic abnormality (excluding ametropia), and 45% had an associated systemic condition. Special testing showed abnormalities in 67% and 95% had treatment directed at their nystagmus.

Conclusions:
The most common diagnosis in this cohort is neurologically non-significant infantile nystagmus syndrome. Eye movement recordings provide a path toward accurate diagnosis and classification. There was a high prevalence of underlying ocular and/or systemic conditions requiring ophthalmic special testing as part of a diagnostic routine. Clinical treatments are available to most patients.

[
J Pediatr Ophthalmol Strabismus
. 2023;60(6):406–410.]
Seroprevalence of Crimean-Congo haemorrhagic fever in Indian cattle and buffaloes
Authors: Sarangi Laxmi N , Mulpuri Hemanjali , Rana Samir K , Prasad Amitesh , Muthappa Ponnanna N 
Published: December 2022

Background & objectives:
Crimean-Congo hemorrhagic fever (CCHF) is an emerging tick-borne viral zoonotic disease of public health importance. Cattle and buffaloes although not showing any clinical symptoms, can be infected by the CCHF virus and act as sources of infection to human beings. The prevalence of CCHF in cattle and buffaloes is important from One health perspective for control of CCHF in humans.

Methods:
A cross-sectional study was undertaken to ascertain the prevalence of CCHFV in cattle and buffaloes of India. Materials and methods: A total of 804 serum samples from four states of India (Gujarat and Rajasthan: human outbreaks reported; Punjab and Haryana: no outbreak reported) were screened by ELISA test detecting nucleoprotein antibodies of CCHFV.

Results:
The overall true prevalence was 8.63% (95% CI: 6.76% – 10.9%). The highest prevalence was recorded in Rajasthan (13.24%) followed by Gujarat (8.68%), Haryana (6.84%), and Punjab (6.51%). Prevalence of CCHF was higher in cattle (9.92%) than buffaloes (5.84%); in females (10.87%) than males (4.99%); in adults (10.18%) than young ones (5.66%). Interestingly, higher seropositivity was recorded in indigenous cattle (12.04%) than in exotic and cross-breed cattle (1.69%) which was statistically significant (p=0.001).

Interpretation & conclusion:
These findings revealed CCHF virus is circulating unnoticed and the prevalence has increased over time which is of public health concern.
Global status of Anaplasma phagocytophilum infections in human population: A 50-year (1970–2020) meta-analysis
Authors: Karshima Solomon Ngutor , Ahmed Musa Isiyaku , Mohammed Kaltume Mamman , Pam Victoria Adamu 
Published: December 2022

Background & objectives:

Anaplasma phagocytophilum causes human granulocytic anaplasmosis; a febrile tick-borne bacterial zoonosis of increasing public health importance in many parts of the world which is life threatening in undiagnosed, misdiagnosed and untreated cases. In this study we determined and reported the global status of the pathogen in man.

Methods:
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was used to perform a systematic review and meta-analysis of data published in six electronic databases between 1970 and 2020. We pooled data using the random-effects model, performed sensitivity analysis by the single study deletion method and assess across study bias by the funnel plot and its statistical significance by the Egger's regression test.

Results:
A total of 7018 cases of A. phagocytophilum were reported from 48,619 individuals examined across 22 countries in three continents. Overall pooled estimate was 8.13% (95% CI: 5.70 – 11.47) with a range of 4.64 (95% CI: 1.78 – 11.54) to 12.18% (95% CI: 7.66 – 18.83) across sub-groups. Regional prevalence was highest in North America 11.07% (95% CI: 3.13 – 32.38), while that in relation to study population was highest among occupationally exposed population 11.41% (95% CI: 5.69 – 21.56).

Interpretation & conclusion:
The study revealed a significant variation in the prevalence of A. phagocytophilum across Asia, Europe and North America, with the highest prevalence in North America and among occupationally exposed population. To curtail the menace of this growing public health crisis, we recommend integrated control programmes involving tick control, the use of appropriate clothing by occupationally exposed population and health education.
Non-Motor Symptoms Burden in Early Stages of Parkinson's Disease
Authors: Sardar Zomer , Liaquat Sumayyah , Yousaf Qudsum , Bano Safia , Numan Ahsan 
Published: December 2022

Background:
Non-motor symptoms (NMSs) in Parkinson's disease (PD) are often overlooked and thus can impede clinical management and significantly reduce the patient's quality of life.

Aims:
The study aimed to determine the burden of NMS in the early stages of PD.

Material and Methods:
A 1-year observational cross-sectional study was conducted at Mayo Hospital, Lahore, in 2019. The MDS-PD criteria were used to diagnose PD patients. The study included patients with Hoehn and Yahr (HY) stages 1–3. The frequency of NMSs was assessed using a non-motor symptom questionnaire (NMSQ), and the non-motor symptom scale (NMSS) score was derived using the NMSS.

Results:
A total of 100 PD patients were enrolled in the study. Sixty-three (63%) were males and 37 (37%) were females. Their age ranged between 45 and 75 years with a mean ± SD of 57.46 ± 8.46. At least one NMS was reported by 84% of patients, with neuropsychiatric symptoms (68%) preponderant, followed by a change in taste and smell (64%). The mean NMSS score is 46.22 ± 22.098 (median 44) with a range from 0 to 88, with the trend being increasing score with the advancing stage.

Conclusion:
The use of the NMSQ and NMSS tools should be standard in clinical practice to identify the severity of the disease and commence appropriate care.
Unequal Representation of Persons with Disabling Mental Health Conditions in the Quota-Based Employment Reservations Notified by a Public Service Commission
Authors: Angothu Hareesh , Philip Sharad , Jadhav Prabhu , Jayarajan Deepak , Jagannathan Aarti , Prasad Krishna M , Thirthalli Jagadish 
Published: December 2022

Introduction:
The Rights of Persons with Disabilities (RPwD) Act 2016 of India intends to achieve greater representation of persons with benchmark disabilities (PwBD) at government establishments and reserve at least 4% of employment vacancies for PwBD. Of this 4%, 1% is reserved for PwBD with disabling mental health conditions (PwBD-MHC) and multiple disabilities, and 1% each for PwBD due to other disabling conditions like blindness, hearing, and locomotor impairment.

Methods:
We analyzed all the employment vacancy announcements (EVAs) made by the Indian union public service commission (UPSC) during the calendar year 2020 for their adherence to quota-based employment reservations (QBER).

Results:
Eighteen vacancy advertisements made during the year 2020, for a total of 1370 posts under various departments, announced a total of 57 posts as reserved for PwBD under the QBER system, satisfying the minimum 4% quota. However, none of these posts is reserved for PwBD-MHC. Further, only 7 out of 1370 were described as suitable for PwBD-MHC, implying that 1363 are not suitable for them.

Conclusions:
The QBER system and the subdivision of quotas are well-intended to achieve the minimum representation of PwBD across all categories of jobs. However, the EVAs by UPSC in the year 2020 did not reserve any posts for PwBD-MHC and perhaps inadvertently excluded them from consideration for the majority of posts announced even under the unreserved category.
Intention to get Vaccinated Against COVID-19 in Iranian Hospital Staff
Authors: Shirahmadi Samane , Khazaei Salman , Jalili Ebrahim , Kazemian Hasan , Sadri Mohadese , Farhadinasab Abdollah , Jenabi Ensiyeh , Bashirian Saeid 
Published: December 2022

Background:
This study aimed to identify the predictors of the intention to receive the COVID-19 vaccine among Iranian health care workers (HCWs) based on the Theory of Planned Behavior (TPB).

Methods:
The study was a descriptive cross-sectional study that was conducted on 473 personnel working in hospitals of Hamadan, in May 2021 and before COVID-19 vaccination on hospital staff. The multi-stage sampling method was used for choosing participants. The survey included socio-demographic, questions related to TPB dimensions, and intention to receive a COVID-19 vaccine. Qualitative and quantitative data analyses were performed using the Chi-square test and T-test, respectively. Predictors of COVID-19 vaccination intention were determined using the logistic regression model.

Results:
Seventy percent of 361 eligible respondents stated their willingness to receive COVID-19 vaccine. The participants with the intention to receive COVID-19 vaccine had higher scores of attitude (7.25 ± 3.92 vs. 4.40 ± 5.14) and norm (3.04 ± 2.92 vs. -0.5 ± 3.18) (P < 0.001). Having an underlying disease and being married were significantly associated with the intention to receive COVID-19 vaccine (P < 0.05). Higher attitude and norm scores as a construct of the TPB were associated with an increase in intention to receive COVID-19 vaccine.

Conclusions:
The results of this study showed that the vaccination intention was affected by social, demographic, health, and behavioral features, such as age, marital status, underlying diseases, subjective norms, and attitude. Therefore, age groups below 50, single people, and those with no underlying diseases were eligible to be the target of interventional programs.
A prospective cohort study to evaluate the outcome of COVID-19 infection in pregnant women in a tertiary care hospital
Authors: Choudhury Mili D. , Ghose Sivaji S. , Maiti G. D. 
Published: December 2022

Background:
Worldwide COVID-19 infection has played havoc. The number of COVID-positive pregnant cases in this study was not far behind the National average. The present study was conducted to evaluate the outcome of COVID-19 infection in pregnant women during their antenatal, intrapartum, and postnatal periods.

Methodology:
The study design was a prospective cohort study. The total number of COVID-19 pregnant patients admitted to this tertiary care hospital from March 2020 to June 2021 was 106 cases at various trimesters. This hospital caters to serving personnel, ex-servicemen, and dependents of the Indian Armed Forces. The community being studied were only the dependents and the serving female personnel. Proper history, presenting complaints, period of gestation, obstetric and systemic examination findings, the severity of symptoms, home isolation or hospital stay, and treatment were all recorded in the form of the questionnaire. Finally, the antenatal, intrapartum, postnatal, and neonatal outcomes of these COVID-positive pregnant patients were compiled and studied.

Results:
The prevalence of COVID-positive pregnant women in the community being studied was 9.9%. About 43.39% of the cases were diagnosed in the third trimester. Ninety-three percent of the patients in the present study were asymptomatic or with very mild symptoms. The mode of delivery in the present study was mostly by cesarean section (69.56%).

Conclusion:
In the present study, pregnancy-associated complications were within the range of 2.8%–3% and only two newborns were COVID positive.
The Alkaloids of Isatis indigotica as Promising Candidates against COVID-19
Authors: Kazemi Farnoosh , Mojarrab Mahdi , Bahrami Gholamreza , Miraghaei Seyed Shahram , Hadidi Saba , Majnooni Mohammad Bagher 
Published: December 2022

Background:
Due to the complexities of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an effective medicinal treatment protocol for this lethal disease with a high prevalence has not been approved yet. This study aimed to explore the efficacy of the main alkaloids of Isatis indigotica, one of the richest plant sources of alkaloids against SARS-CoV-2 targets computationally.

Materials and Methods:
3D structures of the target proteins including 3CLpro; PLpro, and RdRp were downloaded from Protein Data Bank. The structures of ligands were retrieved from PubChem database or optimized by ORCA program. Ritonavir, Lopinavir, Sofosbuvir, and Remdesivir were selected as control inhibitors. Docking calculations were performed by AutoDock Vina option and top-ranked compounds were subjected to molecular dynamics simulation by Gromacs 5.1.4 simulation package.

Result:
The results showed that all 15 compounds had stronger interactions with PLpro in comparison to the other enzymes. Dihydroxylisopropylidenylisatisine A binds to the active site of PLpro with highest affinity (–9.3 kcal/mol) which is even more than the binding constants of Ritonavir and Lopinavir. Of the 15 compounds, Dihydroxylisopropylidenylisatisine A and Isatibisindosulfonic acid B had the highest tendency to bind to 3CLpro. Dihydroxylisopropylidenylisatisine A, Indirubin, Insatindibisindolamide A, Indigo, Insatindibisindolamide B, Isatibisindosulfonic acid B and Isatindosulfonic acid B had the highest RdRp binding affinity even more Remdesivir.

Conclusion:
Based on the results, the highest and weakest interaction with all three enzymes was observed for Dihydroxylisopropylidenylisatisine A and Epigoitrin, respectively. Based on these findings, Dihydroxylisopropylidenylsatistine A might be potential therapeutic candidate against SARS-CoV-2.
Healing Effect of Hydroalcoholic Extract of Humulus lupulus L. (Hops) Aerial Parts on Indomethacin-induced Gastric Ulcer in Rats
Authors: Minaiyan Mohsen , Razzaghi Hamidreza , Yegdaneh Afsaneh , Talebi Ardeshir 
Published: December 2022

Background:

Humulus lupulus L. (Hops) is one of the medicinal plants for which several effects have been reported such as sedative and hypnotic, anti-inflammatory, antioxidant, antibacterial, and anticancer. The fruits of this plant are also used for flavoring and as an aromatizer in the food and beverage industry. This study was done to evaluate the gastric anti-ulcer capacity of this plant in an animal model.

Materials and Methods:
Male Wistar rats were used and the gastric ulcer was induced by oral administration of indomethacin (30 mg/kg, p.o.). The ulcer-bearing rats were orally treated with hydroalcoholic extracts of the leaf (HLE) and fruit (HFE) of hops at similar doses of 50, 100, and 150 mg/kg. Ranitidine (35 mg/kg, p.o.) was used as a reference drug. Gastric acid, pepsin activity, malondialdehyde (MDA), and myeloperoxidase (MPO) were evaluated in gastric tissue, whereas this tissue was examined macroscopically and microscopically.

Results:
The results showed that both extracts (HLE and HFE) at a dose of 150 mg/kg reduced gastric ulcer characteristics such as number and severity, content acidity, pepsin activity, MPO, and MDA values. Also, macroscopic and microscopic images confirmed the effectiveness of the tested extracts in the healing of gastric ulcers.

Conclusion:
It was concluded that leaves and fruits of hops were effective in healing gastric ulcers caused by indomethacin probably by reducing gastric acid and oxidative stress, and this effect was dose-dependent. This effect along with the sedative and anti-Helicobacter pylori properties of hops can be useful in introducing this plant as an antigastric ulcer agent under clinical conditions.
Prediction of Cocrystal Formation Between Drug and Coformer by Simple Structural Parameters
Authors: Shayanfar Shadi , Jouyban Abolghasem , Velaga Sitaram , Shayanfar Ali 
Published: December 2022

Background:
Cocrystal formation between an active pharmaceutical ingredient (API) and coformer is an applicable technique to change the physicochemical and pharmacokinetic properties. Computational methods can overcome the need for extensive experiments and improve the chances of success in the coformer selection. In this method, two compounds connect by non-covalent interactions that form a unique crystalline structure. Prediction of a cocrystal formation between API and coformer can help in the screening and design of new cocrystals.

Methods:
In this study, available data in the literature were applied to develop a prediction method based on binary logistic regression to screen cocrystal formation by sum and absolute difference of structural parameters (the number of rotatable bonds, Abraham solvation parameters, and topological polar surface area) of the two involved compounds.

Results:
The results showed various factors (eight structural parameters of the two compounds) could affect cocrystal formation, and the developed model can predict cocrystallization with a probability of about 90%.

Conclusion:
The related parameter to hydrogen bonding basicity and volume of compounds has the most significant effect on cocrystal formation.