bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wirkleistungsbasierte Bohrprozessüberwachung
Authors: Esch Philipp , Begemann Eva 
Published: August 2023

Abstract
In der Luftfahrt kommen hochfeste Schichtverbundwerkstoffe zum Einsatz, welche zumeist im Nietverfahren gefügt werden. Dies erfordert eine vorausgehende Bohrbearbeitung des Werkstoffverbunds. Da die beiden Einzelwerkstoffe meist gegensätzliche Bohrparameter erfordern (z. B. Titan und CFK) kommen derzeit Kompromissparameter zum Einsatz. Die Fertigungsqualität ist dadurch beschränkt und der Werkzeugverschleiß hoch. Dieser Beitrag stellt eine wirkleistungsbasierte Bohrprozesssteuerung vor, welche die materialspezifische Umschaltung der Prozessparameter ermöglicht. Die Detektionslogik basiert auf dem dynamischen Anteil der Spindelwirkleistung und erweist sich in mehreren Bohrserien als präzise und robust. Zudem ist eine erhöhte Fertigungsqualität zu verzeichnen.
Untersuchung thermo-elastischer Maschineneinflüsse
Authors: Plum Franziska , Brecher Christian , Neus Stephan 
Published: August 2023

Abstract
Die Anforderungen an die Fertigungsqualität steigen in der Produktion stetig. Um diesen Ansprüchen gerecht zu werden, müssen Fertigungsfehler, die zumeist thermo-elastische Fehler sind, vermieden werden. Interne und externe Wärmequellen und -senken, wie z. B. das maschineninterne Kühlsystem und das Hallenklima, beeinflussen das thermoelastische Maschinenverhalten. Der Einfluss dieser beiden Faktoren wird in dieser Arbeit an einer Werkzeugmaschine zur Erweiterung eines Korrekturmodells untersucht.
Kostenreduktion in der Prototypenfertigung
Authors: Holzer Katja , Schaal-Mulacek Henrik , Marker Edgar , Volk Wolfram 
Published: August 2023

Abstract
Am Beispiel von Tiefziehwerkzeugen aus Hochleistungsbeton (engl. Ultra-High Performance Concrete, UHPC) und additiv aufgebautem Polylactide (PLA) wird die Wirtschaftlichkeit von alternativen Fertigungsmethoden für die Prototypenfertigung aus Anwendersicht untersucht. Die Ergebnisse zeigen, dass gerade bei geringen Losgrößen die Analyse der Kosten und Identifizierung von Kostentreibern essentiell ist. Dieser Beitrag soll dabei helfen zu entscheiden, unter welchen Rahmenbedingungen der Einsatz von alternativen Werkzeugwerkstoffen ökonomisch sinnvoll ist.
Automatisierte Erfassung des Freiflächenverschleißes
Authors: Nebeling Paul Helmut , Burghardt Max 
Published: August 2023

Abstract
Verschleiß an Zerspanwerkzeugen mit geometrisch definierter Schneide führt zu schlechter Oberflächenqualität, erhöhten Kräften, Maßabweichungen und Bruch. Bisher wird dieser Verschleiß außerhalb der Maschine oder indirekt (z. B. Durchmesser) erfasst. Der Tausch der Werkzeuge findet nach einer bestimmten Werkstückzahl, Zeit, oder einem Standweg statt. In diesem Beitrag wird ein neuartiges System zur direkten Ermittlung des Freiflächenverschleißes im Arbeitsraum eines Bearbeitungszentrums dargestellt. Dabei wird eine geschützt integrierte Industriekamera mit Objektiv im Arbeitsraum installiert. Die Maschinenachsen bzw. die Bearbeitungsspindel positionieren das Werkzeug davor. Nach einer nur wenige Sekunden dauernden Messung findet die Auswertung des Verschleißes hauptzeitparallel statt.
Fertigungsverfahren PBF-LB/M
Authors: Deckers Tobias , Ammann Thomas , Forêt Pierre , Dubiez-Le-Goff Sophie , Witt Gerd 
Published: August 2023

Abstract
Neuste Studien belegen, dass innerhalb der additiven Fertigungsverfahren, speziell dem pulverbettbasierten Laserstrahlschmelzen (PBF-LB/M) Argon-Helium-Gemische, wie z. B. ADDvance® Laser 230, Vorteile gegenüber Argon oder Stickstoff aufweisen. Diese liegen u. a. in einer Reduktion der Anzahl und der Temperatur von Spritzerpartikeln begründet. Eine Verringerung beider Größen resultiert in einer gesteigerten Prozessstabilität und Bauteilqualität. Die positiven Einflüsse dieses Gemisches werden vorliegend anhand eines komplexen, großflächigen Bauteils aufgezeigt. Anschließend werden die Bauteile, der Prozess und das Pulver aus unterschiedlichen Prozessatmosphären miteinander verglichen. So sind neben einer verbesserten Bauteilqualität eine erhebliche Verringerung der Filterbelegung und Pulververluste feststellbar.
Investigation of Microstructure and Mechanical Properties of Friction Stir Extruded Joints of Dissimilar Materials
Authors: Varshith Shankar Emani , Veeresh Kumar G. B. 
Published: August 2023

Abstract
The welding of steel and aluminum is difficult to join because of their differences in solid solubility, melting points, and formation of intermetallic compounds (IMCs), which may weaken the welded joints. Friction stir welding (FSW) has more feasibility for joining aluminum and mild steel (MS), but IMCs may form, affecting the joint properties. Friction stir extrusion (FSE) is a new derivative technique of FSW that reduces the tool wear and eliminates the formation of IMCs by forming mechanical interlocking joints at the interface. This present study applies the FSE process to join two dissimilar metals: Al6082 alloy and AISI 1020 MS. The FSE process is optimized by adjusting axial force, tool rotation rate, and traverse rate parameters. The mechanism of groove filling was observed and compared (at optimum parameters) with two different profile tools: one is a plain tapered tool and another is a tapered threaded tool; both were made of high-speed steel. The aluminum-MS joints were subjected to shear strength by conducting tension-shear tests using a dynamic servo-controlled fatigue testing machine, as per ASTM E466, Standard Practice for Conducting Force Controlled Constant Amplitude Axial Fatigue Tests of Metallic Materials. The hardness at the joint is evaluated by conducting Rockwell hardness tests, as per ASTM E18, Standard Test Methods for Rockwell Hardness of Metallic Materials. The microstructural characterization is done using optical electron microscope (OEM) and scanning electron microscope (SEM). The obtained results concluded that 30 mm/min is the optimum traverse rate for complete filling of the groove at 14.7-kN axial force and a tool rotation rate of 1,000 rpm. Furthermore, the discussions were made using hardness tests, OEM, SEM, and energy-dispersive spectroscopy analysis.
Dissociable Cognitive Systems for Recognizing Places and Navigating through Them: Developmental and Neuropsychological Evidence
Authors: Kamps Frederik S. , Rennert Rebecca J. , Radwan Samaher F. , Wahab Stephanie , Pincus Jordan E. , Dilks Daniel D. 
Published: August 2023

Recent neural evidence suggests that the human brain contains dissociable systems for “scene categorization” (i.e., recognizing a place as a particular kind of place, for example, a kitchen), including the parahippocampal place area, and “visually guided navigation” (e.g., finding our way through a kitchen, not running into the kitchen walls or banging into the kitchen table), including the occipital place area. However, converging behavioral data — for instance, whether scene categorization and visually guided navigation abilities develop along different timelines and whether there is differential breakdown under neurologic deficit — would provide even stronger support for this two-scene-systems hypothesis. Thus, here we tested scene categorization and visually guided navigation abilities in 131 typically developing children between 4 and 9 years of age, as well as 46 adults with Williams syndrome, a developmental disorder with known impairment on “action” tasks, yet relative sparing on “perception” tasks, in object processing. We found that (1) visually guided navigation is later to develop than scene categorization, and (2) Williams syndrome adults are impaired in visually guided navigation, but not scene categorization, relative to mental age-matched children. Together, these findings provide the first developmental and neuropsychological evidence for dissociable cognitive systems for recognizing places and navigating through them.SIGNIFICANCE STATEMENTTwo decades ago, Milner and Goodale showed us that identifying objects and manipulating them involve distinct cognitive and neural systems. Recent neural evidence suggests that the same may be true of our interactions with our environment: identifying places and navigating through them are dissociable systems. Here we provide converging behavioral evidence supporting this two-scene-systems hypothesis — finding both differential development and breakdown of “scene categorization” and “visually guided navigation.” This finding suggests that the division of labor between perception and action systems is a general organizing principle for the visual system, not just a principle of the object processing system in particular.
MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation
Authors: Park Yeon‐Ji , Dodantenna Niranjan , Kim Yonghyeon , Kim Tae‐Hwan , Lee Ho‐Soo , Yoo Young‐Suk , Heo June , Lee Jae‐Ho , Kwon Myung‐Hee , Kang Ho Chul , Lee Jong‐Soo , Cho Hyeseong 
Published: August 2023

AbstractThe NLRP3 inflammasome plays a key role in responding to pathogens, and endogenous damage and mitochondria are intensively involved in inflammasome activation. The NLRP3 inflammasome forms multiprotein complexes and its sequential assembly is important for its activation. Here, we show that NLRP3 is ubiquitinated by the mitochondria‐associated E3 ligase, MARCH5. Myeloid cell‐specific March5 conditional knockout (March5 cKO) mice failed to secrete IL‐1β and IL‐18 and exhibited an attenuated mortality rate upon LPS or Pseudomonas aeruginosa challenge. Macrophages derived from March5 cKO mice also did not produce IL‐1β and IL‐18 after microbial infection. Mechanistically, MARCH5 interacts with the NACHT domain of NLRP3 and promotes K27‐linked polyubiquitination on K324 and K430 residues of NLRP3. Ubiquitination‐defective NLRP3 mutants on K324 and K430 residues are not able to bind to NEK7, nor form NLRP3 oligomers leading to abortive ASC speck formation and diminished IL‐1β production. Thus, MARCH5‐dependent NLRP3 ubiquitination on the mitochondria is required for NLRP3‐NEK7 complex formation and NLRP3 oligomerization. We propose that the E3 ligase MARCH5 is a regulator of NLRP3 inflammasome activation on the mitochondria.
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer
Authors: Nikolatou Konstantina , Sandilands Emma , Román‐Fernández Alvaro , Cumming Erin M , Freckmann Eva , Lilla Sergio , Buetow Lori , McGarry Lynn , Neilson Matthew , Shaw Robin , Strachan David , Miller Crispin , Huang Danny T , McNeish Iain A , Norman James C , Zanivan Sara , Bryant David M 
Published: August 2023

AbstractDysregulation of the PI3K/AKT pathway is a common occurrence in high‐grade serous ovarian carcinoma (HGSOC), with the loss of the tumour suppressor PTEN in HGSOC being associated with poor prognosis. The cellular mechanisms of how PTEN loss contributes to HGSOC are largely unknown. We here utilise time‐lapse imaging of HGSOC spheroids coupled to a machine learning approach to classify the phenotype of PTEN loss. PTEN deficiency induces PI(3,4,5)P3‐rich and ‐dependent membrane protrusions into the extracellular matrix (ECM), resulting in a collective invasion phenotype. We identify the small GTPase ARF6 as a crucial vulnerability of HGSOC cells upon PTEN loss. Through a functional proteomic CRISPR screen of ARF6 interactors, we identify the ARF GTPase‐activating protein (GAP) AGAP1 and the ECM receptor β1‐integrin (ITGB1) as key ARF6 interactors in HGSOC regulating PTEN loss‐associated invasion. ARF6 functions to promote invasion by controlling the recycling of internalised, active β1‐integrin to maintain invasive activity into the ECM. The expression of the CYTH2‐ARF6‐AGAP1 complex in HGSOC patients is inversely associated with outcome, allowing the identification of patient groups with improved versus poor outcome. ARF6 may represent a therapeutic vulnerability in PTEN‐depleted HGSOC.
Trend in global burden attributable to low bone mineral density in different WHO regions: 2000 and beyond, results from the Global Burden of Disease (GBD) study 2019
Authors: Panahi Nekoo , Saeedi Moghaddam Sahar , Fahimfar Noushin , Rezaei Negar , Sanjari Mahnaz , Rashidi Mohammad-Mahdi , Shobeiri Parnian , Larijani Bagher , Ostovar Afshin 
Published: August 2023

Background
We aimed to document the current state of exposure to low bone mineral density (BMD) and trends in attributable burdens between 2000 and 2019 globally and in different World Health Organization (WHO) regions using the Global Burden of Disease (GBD) study 2019.

Methods
We reviewed the sex-region-specific summary exposure value (SEV) of low BMD and the all-ages numbers and age-standardized rates of disability-adjusted life years (DALYs), years lived with disability (YLDs), years of life lost (YLLs), and deaths attributed to low BMD. We compared different WHO regions (Africa, the Eastern Mediterranean Region, Europe, Region of the Americas, Southeast Asia, and Western Pacific), age categories, and sexes according to the estimates of the GBD 2019 report.

Results
The global age-standardized SEV of low BMD is estimated to be 20.7% in women and 11.3% in men in 2019. Among the WHO regions, Africa had the highest age-standardized SEV of low BMD in women (28.8% (95% uncertainty interval 22.0–36.3)) and men (16.8% (11.5–23.8)). The lowest SEV was observed in Europe in both women (14.7% (9.9–21.0)) and men (8.0% (4.3–13.4)). An improving trend in the global rate of DALY, death, and YLL was observed during 2000–2019 (−5.7%, −4.7%, and −11.9% change, respectively); however, the absolute numbers increased with the highest increase observed in global YLD (70.9%) and death numbers (67.6%). Southeast Asia Region had the highest age-standardized rates of DALY (303.4 (249.2–357.2)), death (10.6 (8.5–12.3)), YLD (133.5 (96.9–177.3)), and YLL (170.0 (139–197.7)).

Conclusions
Overall, the highest-burden attributed to low BMD was observed in the Southeast Asia Region. Knowledge of the SEV of low BMD and the attributed burden can increase the awareness of healthcare decision-makers to adopt appropriate strategies for early screening, and also strategies to prevent falls and fragility fractures and their consequent morbidity and mortality.
Impactos en un bosque tropical ralo con paca en la selva amazónica sur del Perú
Authors: Vásquez Flores Marco Antonio , Jave Nakayo Jorge Leonardo 
Published: August 2023

Debido a diversas actividades de extracción de recursos naturales, se generan impactos ambientales, en este caso el objetivo es analizar cuáles son estos impactos en un bosque tropical ralo con paca en la selva amazónica sur del Perú, los cuales pueden ser restaurados con medidas y procedimientos adecuados, lo cual parte de una metodología que comprende el conocimiento profundo antes de iniciar la deforestación del bosque, realizando un detallado inventario de la flora, fauna y suelo existente en el área a intervenirse, continuar este trabajo durante las actividades de perforación de los pozos de exploración y posteriormente con la revegetación y monitoreo, realizando observaciones y captando información de los bosques aledaños. A fin de minimizar los impactos ambientales y compensar la deforestación es necesario diseñar la estrategia de restauración del bosque tropical en el área intervenida para lograr la recuperación del ecosistema afectado y procurar darles el beneficio directo a las comunidades apoyando su desarrollo autosostenible.
El análisis del impacto en el suelo, vegetación, fauna y en las comunidades cercanas trae como consecuencia un conocimiento importante para que posteriormente se restaure el ecosistema, el sistema de captura de información de la composición del suelo mediante análisis de muestras, el inventario de la flora en el área y con la metodología de las cámaras trampa permitió conocer la fauna existente, a la vez complementado con las necesidades de las comunidades cercanas, se obtiene una amplia información que da buenos resultados, los impactos alcanzados en estos cuatro análisis pueden ser revertidos, y ayudan a realizar una buena estrategia de restauración del área afectada.
Los indicadores resultantes deberán ser monitoreados por 3 años, con visitas físicas y por 10 años adicionales mediante tecnología remota.
Evaluación de Metales Traza en Agua y Sedimento Marino en la Ensenada Mackellar, Antártica (2018-2019)
Authors: Alfaro Jaucha Jonathan Delio , Martínez Gamboa Carlos Alberto , Tam Málaga Jorge , Orozco Moreyra Rita 
Published: August 2023

Existe preocupación por el impacto antropogénico sobre el ecosistema Antártico, por tal motivo el Instituto del Mar del Perú realizó las expediciones científicas Vigésimo Quinta y Sexta del Perú hacia la Antártica. Las investigaciones se llevaron a cabo en el verano austral 2018-2019 a bordo del buque BAP Carrasco en la ensenada Mackellar ubicada en la Isla Rey Jorge, en la cual se tomaron muestras de agua y sedimento marino en 11 estaciones de muestreo para la evaluación de metales traza (Cu, Zn, As y Pb) mediante espectrometría de masas por plasma acoplado inductivamente (ICP-MS). Se observó que los mayores niveles de concentración de Cu, As y Pb en matriz agua correspondieron al año 2019, en comparación con el año 2018. Asimismo, estos metales, no superaron los Estándares de Calidad Ambiental (ECA), por lo que se considera que aún no hay riesgos de contaminación acuática. Sin embargo, hay una tendencia de incremento de concentración de estos metales cada año. Por otro lado, las concentraciones de Cu y As en sedimento superaron los ECA, por lo que estos metales podrían causar efectos adversos en el ecosistema marino.
Демографическая структура семей и домохозяйств в России, её динамика по данным переписей населения
Authors: Прокофьева Лидия Михайловна , Корчагина Ирина Ивановна 
Published: August 2023

Анализ демографической структуры семей и домохозяйств – необходимая составляющая для понимания действующего устройства общества в различных ракурсах, от социологических до экономических. Оценка существующей структуры населения, ее динамики необходима для решения важных вопросов развития экономики, особенно системы образования, здравоохранения, социальной политики, сферы услуг. Важными являются региональные и поселенческие особенности демографической структуры семей, определение которых должно помочь в вопросах дифференцированного подхода к принятию решений по экономической и социальной политике.
В работе представлен анализ результатов переписи населения 2020 г. (проведена в 2021 г.) по демографической структуре домохозяйств и семейных ячеек, и ее динамика с использованием материалов предыдущих переписей и микропереписей населения России. Анализируемая типология домохозяйств выделяет основные группы по наличию или отсутствию семейного ядра (супружеская пара с детьми или без детей, один из родителей с детьми), числу детей, составу домохозяйства (простые - сложные), что согласуется с принципами демографической типологии семей в статистике, заложенными А.Г. Волковым еще при подготовке переписи 1970 г. Домохозяйства в России становятся все мельче, значительно вырос удельный вес одиночек, причем по сравнению с прошлыми переписями среди них впервые стали преобладать лица трудоспособного возраста, однако это характерно только для городского населения. Важно отметить снижение доли семей с детьми, но в то же время рост числа детей в этих семьях, что, в какой-то мере объясняется изменениями в системе мер социальной поддержки семей с детьми в рамках проводимой демографической политики. Динамика структуры семейных ячеек показывает тенденцию к все более частому проживанию детей старше 18 лет с родителями без создания собственной семьи, также как и усиление нуклеаризации семейных ячеек, т.е. большей распространенности проживания детей, создавших семью, отдельно от старших родственников.
Physics-Based Modeling to Understand and to Propose Forecasting Methods of Induced Seismicity
Authors: Boyet Auregan , De Simone Silvia , Vilarrasa Víctor 
Published: August 2023

Abstract
Induced seismicity compromises the widespread deployment of geoenergy applications that contribute to mitigate climate change. In particular, the development of Enhanced Geothermal Systems (EGS) has been hindered by the risk of induced seismicity, mostly caused by hydraulic stimulation aimed at enhancing the permeability of deep hot crystalline rocks. Injection-induced seismicity has been traditionally attributed to fluid pressure buildup, which destabilizes fractures and faults. However, the largest seismic events commonly occur after the stop of injection, when pore pressure drops and both the magnitude and frequency of induced seismicity is expected to decrease. This counterintuitive phenomenon is not well understood. Yet, understanding the triggering mechanisms is the key to reliably forecast and manage induced seismicity. Here, we investigate the triggering mechanisms of co- and post-injection seismicity using coupled hydromechanical models, considering both a homogeneous and a fault-crossed domain, based on the case of Basel EGS (Switzerland). We find that the combination of pressure diffusion, poroelastic stressing, and static stress transfer explains the occurrence of induced seismicity, especially after the stop of injection, significantly better than the pore pressure alone. Considering a fault zone, which is more permeable and deformable than the surrounding rock, amplifies pressure diffusion along the fault and causes anisotropic variations of the stress field that lead to an increase in the seismicity rate that is orders of magnitude larger than for the homogeneous domain. These results point out that identifying the main geological structures through subsurface characterization is key to improve physics-based induced seismicity forecasting.
Formação docente e aprendizagem criativa: O papel do professor no processo de aplicação da aprendizagem criativa na Educação
Authors: Câmara Igor , Mascarenhas Suely Aparecida Do Nascimento 
Published: August 2023

: Este artigo tem como finalidade discorrer e apontar as possibilidades e pontecialidades da aprendizagem criativa no contexto educacional. A formação docente neste sentido, se torna um dos fatores essenciais para que o processo de abordagem criativa seja aplicado na seara de ensino. O objetivo deste estudo é relatar a percepção e o conhecimento de professores e pesquisadores de diversas áreas do conhecimento acerca da importância do papel do professor no processo de aplicação da abordagem da aprendizagem criativa na educação considerando as possibilidade e potencialidade, além dos diversos desafios que a educação nacional enfrenta. Este artigo conta com o apoio financeiro da Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM), da Universidade Federal do Amazonas (UFAM) e da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). A pesquisa é de natureza teórico-bibliográfica tendo como pressuposto a visão da metaepistemologia de contextos como metodologia utilizada. (MASCARENHAS, et al, 2019). Compreendemos que este manuscrito poderá colaborar para futuras pesquisas sobre a temática além de produzir, promover, sistematizar e consolidar o conhecimento sobre esse importante tema e sua necessária aplicação na educação.Palavras- chave: Aprendizagem criativa; formação docente; professor