bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gabapentin, Concomitant Prescription of Opioids, and Benzodiazepines among Kidney Transplant Recipients
Authors: Chen Yusi , Ahn JiYoon B. , Bae Sunjae , Joseph Corey , Schnitzler Mark , Hess Gregory P. , Lentine Krista L. , Lonze Bonnie E. , Segev Dorry L. , McAdams-DeMarco Mara 
Published: January 2023

Background
Gabapentinoids, commonly used for treating neuropathic pain, may be misused and coprescribed with opioid and benzodiazepine, increasing the risk of mortality and dependency among kidney transplant recipients.

Methods
We identified adult kidney transplant recipients who enrolled in Medicare Part D in 2006–2017 using the United States Renal Data System/Medicare claims database. We characterized recipients' post-transplant concomitant prescription of gabapentinoids, opioids, and benzodiazepine stratified by transplant year and recipient factors (age, sex, race, and diabetes). We investigated whether concomitant prescriptions were associated with postkidney transplant mortality using Cox regression. Models incorporated inverse probability weighting to adjust for confounders.

Results
Among 63,359 eligible recipients, 13% of recipients filled at least one gabapentinoid prescription within 1 year after kidney transplant. The prevalence of gabapentinoid prescriptions increased by 70% over the study period (16% in 2017 versus 10% in 2006). Compared with nonusers, gabapentinoids users were more likely to have diabetes (55% versus 37%) and obesity (46% versus 34%). Of the 8509 recipients with gabapentinoid prescriptions, 45% were coprescribed opioids, 7% were coprescribed benzodiazepines, and 3% were coprescribed both opioids and benzodiazepines. Compared with no study prescriptions, gabapentinoid monotherapy (adjusted hazard ratio [aHR]=1.25; 95% confidence interval [CI], 1.16 to 1.32) and combination therapy (gabapentinoids and opioids [aHR=1.49; 95% CI, 1.39 to 1.60], gabapentinoids and benzodiazepines [aHR=1.46; 95% CI, 1.03 to 2.08], and coprescribing all three [aHR=1.88; 95% CI, 1.18 to 2.98]) were all associated with a higher risk of postkidney transplant mortality.

Conclusions
Gabapentinoid coprescription with both benzodiazepines and opioids among kidney transplant recipients increased over time. Kidney transplant recipients prescribed gabapentinoids had a higher risk of post-transplant mortality, and the risk was higher with opioids or benzodiazepine coprescription.
Development of a Patient-Reported Outcomes Tool to Assess Pain and Discomfort in Autosomal Dominant Polycystic Kidney Disease
Authors: Oberdhan Dorothee , Cole Jason C. , Atkinson Mark J. , Krasa Holly B. , Davison Sara N. , Perrone Ronald D. 
Published: January 2023

Background
Pain has been identified as a core outcome for individuals with autosomal dominant polycystic kidney disease (ADPKD), but no disease-specific pain assessment has been developed using current development methodology for patient-reported outcomes (PRO) instruments. We developed and validated an ADPKD-specific pain questionnaire: the ADPKD Pain and Discomfort Scale (ADPKD-PDS).

Methods
Conceptual underpinnings were drawn from literature review, concept elicitation, expert consultation, and measurement performance. In the qualitative analysis phase, concepts were elicited from focus groups of adults with ADPKD, and the resulting draft instrument was refined using cognitive debriefing interviews with individuals with ADPKD. For quantitative analysis, adults with ADPKD completed the draft instrument and other PRO tools in an online survey, and a follow-up survey was conducted 3–4 weeks later. Survey responses were analyzed for item-level descriptive statistics, latent model fit statistics, item discrimination, item- and domain-level psychometric statistics, test-retest reliability, responsiveness to change, and convergent validity.

Results
In the qualitative phase, 46 focus groups were conducted in 18 countries with 293 participants. Focus groups described three conceptually distinct types of ADPKD-related pain and discomfort (dull kidney pain, sharp kidney pain, and fullness/discomfort). In the quantitative phase, 298 adults with ADPKD completed the online survey, and 108 participants completed the follow-up survey. After iterative refinement of the instrument, latent variable measurement models showed very good fit (comparative fit and nonnormed fit indices both 0.99), as did item- and domain-level psychometric characteristics. The final ADPKD-PDS contains 20 items assessing pain severity and interference with activities over a 7-day recall period.

Conclusions
The ADPKD-PDS is the first validated tool for systematically assessing pain and discomfort in ADPKD.
A Health Survey–Based Prediction Equation for Incident CKD
Authors: Noel Ariana J. , Eddeen Anan Badder , Manuel Douglas G. , Rhodes Emily , Tangri Navdeep , Hundemer Gregory L. , Tanuseputro Peter , Knoll Gregory A. , Mallick Ranjeeta , Sood Manish M. 
Published: January 2023

Background
Prediction tools that incorporate self-reported health information could increase CKD awareness, identify modifiable lifestyle risk factors, and prevent disease. We developed and validated a survey-based prediction equation to identify individuals at risk for incident CKD (eGFR <60 ml/min per 1.73 m2), with and without a baseline eGFR.

Methods
A cohort of adults with an eGFR ≥70 ml/min per 1.73 m2 from Ontario, Canada, who completed a comprehensive general population health survey between 2000 and 2015 were included (n=22,200). Prediction equations included demographics (age, sex), comorbidities, lifestyle factors, diet, and mood. Models with and without baseline eGFR were derived and externally validated in the UK Biobank (n=15,522). New-onset CKD (eGFR <60 ml/min per 1.73 m2) with ≤8 years of follow-up was the primary outcome.

Results
Among Ontario individuals (mean age, 55 years; 58% women; baseline eGFR, 95 (SD 15) ml/min per 1.73 m2), new-onset CKD occurred in 1981 (9%) during a median follow-up time of 4.2 years. The final models included lifestyle factors (smoking, alcohol, physical activity) and comorbid illnesses (diabetes, hypertension, cancer). The model was discriminating in individuals with and without a baseline eGFR measure (5-year c-statistic with baseline eGFR: 83.5, 95% confidence interval [CI], 82.2 to 84.9; without: 81.0, 95% CI, 79.8 to 82.4) and well calibrated. In external validation, the 5-year c-statistic was 78.1 (95% CI, 74.2 to 82.0) and 66.0 (95% CI, 61.6 to 70.4), with and without baseline eGFR, respectively, and maintained calibration.

Conclusions
Self-reported lifestyle and health behavior information from health surveys may aid in predicting incident CKD.

Podcast
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_01_10_CJN0000000000000035.mp3
Dialysis in Israeli Children between 1990 and 2020: Trends and International Comparisons
Authors: Regev-Epstein Lilach C. , Frishberg Yaacov , Davidovits Miriam , Landau Daniel , Magen Daniella , Weismann Irit , Stern-Zimmer Michal , Beckerman Pazit , Keinan-Boker Lital , Calderon-Margalit Ronit , Vivante Asaf 
Published: January 2023

Background
Childhood kidney failure is a rare condition with worldwide clinical variability. We used a nationwide multicenter analysis to study the pretransplant course of the entire Israeli pediatric kidney failure population over 30 years.

Methods
In this nationwide, population-based, historical cohort study, we analyzed medical and demographic data of all children treated with KRT and reported to the Israeli kidney failure registry in 1990–2020. Statistical analysis was performed with incidence rate corrected for age, ethnicity, and calendar year, using the appropriate age-related general population as denominator.

Results
During the last 30 years, childhood incidence of kidney failure decreased. Average incidence in 2015–2019 was 9.1 cases per million age-related population (pmarp). Arab and Druze children exhibited higher kidney failure incidence rates than Jewish children (18.4 versus 7.0 cases pmarp for minorities versus Jews). The most common kidney failure etiologies among Arab and Jewish children were congenital anomalies of the kidney and urinary tract (approximately 27%), followed by cystic kidney diseases among Arab children (13%) and glomerulonephritis among Jewish children (16%). The most common etiology among Druze children was primary hyperoxaluria type 1 (33%). Israel's national health insurance provides access to primary health care to all citizens. Accordingly, waiting time for deceased-donor transplantation was equal between all ethnicities. Living-donor kidney transplantation rates among minority populations remained low in comparison with Jews over the entire study period. Although all patient groups demonstrated improvement in survival, overall survival rates were mainly etiology dependent.

Conclusions
In Israel, Arab and Druze children had a higher incidence of kidney failure, a unique etiological distribution, and a lower rate of living-donor kidney transplantations compared with Jewish children.
Contribuições da Teoria dos Campos Conceituais no processo formativo dos estudantes dos anos iniciais do ensino fundamental
Authors: MINÉ VALDETE APARECIDA DO AMARAL , IGLIORI SONIA BARBOSA CAMARGO 
Published: January 2023

Este artigo tem como objetivo apresentar representações de situações-problema de estruturas aditivas realizadas por crianças dos anos iniciais do ensino fundamental de uma escola pública do interior de São Paulo, no contexto da Teoria dos Campos Conceituais de Vergnaud, no âmbito da Abordagem Documental do Didático (ADD), constructo teórico desenvolvido por Luc Trouche. A Teoria dos Campos Conceituais foi elaborada para explicar o processo das estruturas aditivas, multiplicativas, álgebra e relação entre número-espaço. Tendo, para esse artigo o principal aporte teórico Vergnaud (1985), que traz as representações, conceito e esquemas para a compreensão da evolução do conhecimento das crianças dos anos iniciais do ensino fundamental. Assim, iniciamos fazendo uma contextualização das ideias da estrutura aditiva para compreensão das situações-problema apresentadas em seu desenvolvimento no campo do conhecimento.
NIGERIA: DECOLONIAL CLIMATE ADAPTATION AND CONFLICT. EVIDENCE FROM COASTAL COMMUNITIES OF THE NIGER DELTA
Authors:   Department of Political and Administrative Studies University of Port Harcourt, Rivers State, Nigeria, ALLEN Fidelis 
Published: January 2023

The paper proceeds on the assumption that decoloniality matters in tackling the global climate crisis, conflict, and development at the community level across countries with high vulnerabilities. Africa remains one of the most vulnerable regions in the world. By examining what decolonisation means in climate adaptation and the experience of six communities in three states in the Niger Delta of Nigeria, this article contributes to the conceptualization of the decolonial discourse of climate adaptation, development and conflict understood as conditions favourable to the crisis. I analysed qualitative data obtained from the coastal communities through observation, focus group discussions, and interviews. The results showed a reinforcement of positions in a segment of the literature on decolonial climate adaptation in communities in some parts of the world. Migration, alternative sources of livelihood, embarkment of shorelines, skills development, vocations, and infrastructure development are among legitimate adaptive measures local communities are adopting. At the same time, maladaptive measures such as piracy, kidnapping, illegal oil refining, and gangsterism are common. These antisocial behaviours lead to conflict and contribute to making climate change a very complex problem. Decolonial climate adaptation requires collaborative interventions at the level of the community, sub-national, national, and multilateral fronts. The fact that climate change is a global problem with unequal impact means that the capacity to respond well to it at the community, sub-national, national, regional, continental, and international levels is crucial in addressing the crisis. The role of decoloniality in the handling of the effects of climate change in the community may take the form of integration of local and western knowledge. The decolonial framework would appear to be elastic with a potential conceptual role of critical assessment of existing frameworks, outcomes, impact, and power relations. One of the striking messages in this analysis is the likely role of local knowledge in reducing the risk of social tension and criminal conflict, and the need to strengthen it to increase the resilience and well-being of people. Keywords: Decolonisation, climate, adaptation, development, Africa, Nigeria, coastal communities
Technical Condition Monitoring for Telecommunication and Radioelectronic Systems with Redundancy
Authors: Zaliskyi Maksym , Solomentsev Oleksandr , Zuiev Oleksiy , Pavlenko Maksim , Zakharchenko Iryna , Petrova Yuliia 
Published: January 2023

Abstract
The telecommunication and radioelectronic systems with redundancy are widely used in different branches of human activity. To provide the necessary reliability level of equipment, the operation system is utilized. That system contains intended use, maintenance, repair, technical condition monitoring, and others. The damages, faults and failures are usually observed during the lifecycle of telecommunication and radioelectronic systems. They can lead to deterioration of equipment technical condition. The deterioration of technical condition can be detected during observation of diagnostic variable and reliability parameter. This article concentrates on the synthesis and analysis of statistical data processing procedure for deterioration detection while operating telecommunication and radioelectronic systems with redundancy. For the purpose of reliability estimation based on different redundancy methods, statistical data processing procedure synthesis was carried out using multiple hypothesis testing and detection criterion. The analysis problem was solved using Monte- Carlo simulation method, which allowed constructing operating characteristics. The obtained results can be used in the process of design and improvement of operation systems for telecommunication and radioelectronic equipment.
Automatic Vessel Steering in a Storm
Authors: Zinchenko Serhii , Tovstokoryi Oleh , Mateichuk Vadym , Nosov Pavlo , Popovych Ihor , Gritsuk Igor 
Published: January 2023

Abstract
The issues of automatic vessel control in a storm are considered in the paper. Vessel control in a storm is the most difficult stage in the vessel’s wiring, as it requires quick decisions to be made in difficult conditions. Practical experience shows that the deterioration of the working conditions of the crew is usually associated with an increase in the number of control errors, which is completely unacceptable in stormy conditions. To assess the safe speed and course in a storm, Yu. V. Remez has proposed a universal storm diagram, which allows identifying unfavourable combinations of vessel speed and course angles of the waves – the resonant zones, and avoid them. The universal Remez diagram provides for graphical calculations, which, in combination with the visual determination of the wave parameters, gives a very low accuracy. The article examines the possibility of automatic control of a vessel in a storm by automatic measurement of motion parameters and wave parameters, automatic calculation in the onboard controller of the vessel optimal safe speed and course during a storm, automatic maintenance of the optimal safe speed and course of the vessel. The automatic control significantly increases the accuracy of calculations, excludes the human factor, reduces the depletion of the crew, and increases the reliability of the vessel control in a storm. The efficiency and effectiveness of the method, algorithmic and software were tested on Imitation Modelling Stand in a closed loop with mathematical vessel models of the navigation simulator Navi Trainer 5000.
Bank Regulation in the Selected Sub-Saharan African Countries: Dynamics and Trends
Authors: Thamae Retselisitsoe I. , Odhiambo Nicholas M. , Khumalo John M. 
Published: January 2023

Abstract
This paper discusses the dynamics of bank regulation in the Sub-Saharan African (SSA) region during the period before the 1990s and post 1990s and describes the trends in bank regulatory measures between 1995 and 2017 using the updated databases of the World Bank’s Bank Regulation and Supervision Surveys. Before the 1990s, bank regulation in the majority of SSA countries was inadequate and that led to multiple occurrences of banking crises. As a result, many countries introduced the financial sector reforms from the late 1980s that included major adjustments in the banking regulatory and supervisory frameworks. In both low-income and middle-income SSA economies, bank regulatory environment became more stringent over time, driven by increased restrictions on bank entry barriers and ownership structure, as well as the introduction of macroprudential policies in the case of the former, while in the case of the latter, it was influenced by more restrictions on bank ownership structure and capital regulation requirements, as well as the adoption of macroprudential policies. Overall, the bank regulatory environment was slightly more stringent in middle-income than in low-income SSA countries over the period under review.
Money Supply Determination Process for Japan
Authors: Ongan Serdar , Gocer Ismet 
Published: January 2023

Abstract
This study re-investigates the money supply determination process for Japan. The methodology of this study, which differs from previous studies, is constructed on the assumption of potential nonlinear (asymmetric) relations between money supply and monetary base via money multiplier. To this aim, the nonlinear autoregressive distributed lag (ARDL) model by Shin, Yu and Greenwood-Nimmo, (2014) is applied. This model allows us to examine the endogeneity and exogeneity of the money supply determination process via the linkage of the money multiplier under expansionary and contractionary monetary policies of the Bank of Japan (BOJ) separately in a nonlinear manner. The main findings of the study indicate that the money supply determination process is endogenous with an unstable money multiplier for Japan for M1. However, this endogeneity in the BOJ’s contractionary monetary policy is more than its expansionary policy. This can be interpreted that the BOJ’s expansionary monetary policy has more of a determining role on money supply determination than its contractionary monetary policy. Additionally, the same findings indicate that the BOJ has more power to determine M1 than M2. This result can be interpreted that when the measure of money broadens the BOJ’s controllability on money supply decreases. In contrast, in our Canadian study (Ongan and Gocer, 2019) with the same nonlinear ARDL model, we concluded that the Canadian central bank (BOC) was able to determine money supply exogenously for M1, unlike the Japanese central bank (BOJ), and the money multiplier was stable for Canada.
Family Business and Religion – Research Agenda
Authors: Bąkiewicz Anna , Kasuma Jati , Hermawan Asep 
Published: January 2023

Abstract

Objective: The aim of the study is to find out what is our state of knowledge about the importance of religion for the activity of family businesses. The literature review on the impact of four major religions: Buddhism, Christianity, Hinduism and Islam on the family business development has been made. The issues as business development, resource allocations, risk taking, succession and business ethics in family business under the influence of religion have been discussed. The synthesis effect of the study is the picture of a specific research field. And, as a result of the study the important niches in our knowledge, main barriers of research development and most inspiring directions for future studies have been identified.
Consumer Attitudes towards Pro-ecological Activities in Accommodation Facilities
Authors: Dębski Maciej , Andrzejczyk Robert , Borkowska-Niszczota Małgorzata , Krawczyk Adriana 
Published: January 2023

Abstract

Objective: The main aim of the article is to analyse the respondents’ attitudes towards selected pro-environmental practices of enterprises providing accommodation services and the factors conditioning their involvement in the activities implemented in the facilities.

Methodology: The study is empirical in nature and is based on the results of an empirical survey that was carried out in the period December 2021–April 2022 in Poland. The survey used the diagnostic survey method, and 575 respondents took part in it. The main hypothesis assumes that customers of accommodation facilities appreciate the pro-environmental activities used in them.

Findings: The survey results show that the respondents are sensitive to environmental issues and try to apply in practice the principles leading to environmental protection. They also emphasise that they would be more willing to stay in “green” facilities, although the application of sustainable development principles is not a key factor for them in choosing a facility.

Value Added: The survey of 575 respondents indicated, similar to other studies, a positive attitude towards activities aimed at protecting the environment. At the same time, however, it showed that tourists are not always willing to make sacrifices during their stay related to either their comfort or the price of the service. This fact has practical implications for hotel managers and must be taken into account.

Recommendations: The survey confirmed that consumers have a positive perception of environmental activities in hotels, so activity in this area can be an element of building their competitiveness.
Awake craniotomy for operative treatment of brain gliomas – experience from University Medical Centre Ljubljana
Authors: Zele Tilen , Velnar Tomaz , Koritnik Blaz , Bosnjak Roman , Markovic-Bozic Jasmina 
Published: January 2023

Abstract

Background
Awake craniotomy is a neurosurgical technique that allows neurophysiological testing with patient cooperation during the resection of brain tumour in regional anaesthesia. This allows identification of vital functional (i.e. eloquent) brain areas during surgery and avoidance of their injury. The aim of the study was to present clinical experience with awake craniotomy for the treatment of gliomas at the University Medical Centre Ljubljana from 2015 to 2019.

Patients and methods
Awake craniotomy was considered in patients with a gliomas near or within the language brain areas, in all cases of insular lesions and selected patients with lesions near or within primary motor brain cortex. Each patient was assessed before and after surgery.

Results
During the 5-year period, 24 awake craniotomies were performed (18 male and 6 female patients; average age 41). The patient's cooperation, discomfort and perceived pain assessed during the awake craniotomy were in majority of the cases excellent, slight, and moderate, respectively. After surgery, mild neurological worsening was observed in 13% (3/24) of patients. Gross total resection, in cases of malignant gliomas, was feasible in 60% (6/10) and in cases of low-grade gliomas in 29% (4/14). The surgery did not have important negative impact on functional status or quality of life as assessed by Karnofsky score and Short-Form 36 health survey, respectively (p > 0.05).

Conclusions
The results suggest that awake craniotomy for treatment of gliomas is feasible and safe neurosurgical technique. The proper selection of patients, preoperative preparation with planning, and cooperation of medical team members are necessary for best treatment outcome.