bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictive value of preoperative luteinizing hormone to follicle stimulating hormone ratio for ovulation abnormalities recovery after laparoscopic sleeve gastrectomy: A prospective cohort study
Authors: Liu Fashun , Li Yue , Ye Zhenxiong , Jiang Xiaohua , Liu Ruichen , Li Zhen , Ma Chiye 
Published: January 2023

IntroductionObesity-related ovulation abnormalities (OA) affect fertility. LSG is the most frequent bariatric operation. However, no research has identified a reliable indicator for predicting OA recovery after LSG. The purpose of this research was to examine the prognostic usefulness of preoperative the luteinizing hormone (LH) to follicle-stimulating hormone (FSH) ratio (LFR).MethodsOur department conducted a prospective study from 2016 to 2021. Venous blood was typically tested 3 days before surgery to get the preoperative LFR. Descriptive data, preoperative and postoperative variables were also collected. Binary logistic regression related preoperative LFR with OA recovery. The receiver operating characteristic (ROC) curve evulated preoperative LFR’s predictive capability.ResultsA total of 157 women with a complete follow-up of one year were included. LFR was the only factor linked with OA (P &lt; 0.001). AUC (area under the ROC curve) = 0.915, cutoff = 1.782, sensitivity = 0.93, and specificity = 0.82.DiscussionOverall, LSG has a favorable surgical result, with a %TWL of 66.082 ± 12.012 at 12 months postoperatively. Preoperative sexual hormone levels, as expressed by LFR, has the potential to predict the fate of OA following LSG at one year post-operatively.
Association of obesity with headache among US children and adolescents: Evidence from NHANES 1999-2004
Authors: Bu Xin-Xin , Zhu Liang-Hua , Wang Ze-Mu , Lu Chao , Chen Hui , Yu Di 
Published: January 2023

BackgroundChildren and adolescents increasingly commonly suffer from obesity and headache. It has been confirmed that there is an association between obesity and headache in adults; however, evidence of such an association in paediatric populations is still controversial. Therefore, this study examined the relationship between obesity and headache among children and adolescents in the US.MethodsThe cross-sectional data of 3948 participants were obtained from the National Health and Nutrition Examination Survey 1999–2004. Weighted logistic regression models were applied to investigate the association between obesity and headache. Subgroup analysis stratified by sex and age was performed to explore the potential difference in the association of paediatric obesity with headache. The performance of paediatric obesity on headache was assessed by receiver operating characteristic (ROC) curve.ResultsThe present study involved 3948 participants, of whom 713 (18.1%) had headache. Compared to those without headache, participants with headache tended to be girls and adolescents, have less calcium intake, and have higher levels of body mass index (BMI), C-reactive protein (CRP), serum ferritin and triglycerides (TGs) (all P &lt; 0.05). After fully adjusting for potential confounders, the ORs with 95% CIs for headache were 1.03 (0.58–1.54) and 1.25 (0.68–2.30) for overweight and obese participants in comparison with normal-weight controls, respectively, implying no association of paediatric obesity with headache independent of other potential confounding factors. In addition, although higher odds of headache were noted in girls and adolescents (aged 10–17 years), no statistically significant difference was found across any subgroups. The area under the ROC (AUC) of paediatric obesity on headache was 0.634.ConclusionsIn summary, our study indicated that obesity is not associated with headache among US children and adolescents. Further prospective studies with larger sample size are needed to validate our findings.
Ignition characteristics of methane-air mixture at low initial temperature
Authors: Yang Chao , Han Qing , Liu Haibo , Wang Yuanyuan , Cheng Ran 
Published: January 2023

In this paper, FLUENT software coupled with the chemical reaction mechanism is used to study the ignition characteristics of methane-air mixtures at low temperature. Variations of the main free radical concentrations, the critical conditions for a successful ignition and the chemical reaction rate of each elementary reaction for a failure ignition are obtained, respectively. Results indicate that the consumption of methane immediately affects the concentration distribution of carbon monoxide, which presents the opposite relationship with that of methane. Mass fractions of the intermediate products and H, O free radicals are low in the burnt zone and unburnt zone, whereas reach the maximum on the flame front. OH is not only the intermediate free radical, but also the combustion product remained by the intermediate reactions. At a low temperature of 150 K, the critical radius and temperature of methane ignition are 4.6 mm and 1180 K, respectively. When ignition radius is smaller than the critical value, the failed ignition of methane is caused by the termination of the elementary reactions: R8: H + O2 = OH + O, R9: OH + O = O2 + H, R12: O + H2O = 2OH and R13: 2OH = O + H2O. However, when ignition temperature is lower than the critical value, because of the failed initiation of elementary reaction R1: CH4 = CH3 + H, the combustion of methane is not occurred.
Optimization of structural and operational parameters for the multi-size sinter vertical waste heat recovery with the objective of the income exergy
Authors: Zhang Sizong , Huang Linjing , Liu Xiaohong , Wang Hui 
Published: January 2023

To be consistent with the actual production, this paper establishes the 2-D steady-state mathematical model of the porous media to numerically analyze influences of structural and operational parameters on the vertical cooling process by applying particle characteristic parameters, and heat transfer and resistance correlations of the multi-size sinter. Considering comprehensive effects of the temperature and pressure drop, the operating and structural parameters are optimized with the objective of the maximum income exergy of the gas. Results show that the numerical model established in this paper can well predict the gas-solid heat transfer process in the sinter bed with the maximum error of 7%. Besides, the income exergy of the gas increases and decreases with the sinter outlet temperature and gas outlet temperature increasing, respectively. The reduction in the equivalent particle diameter is conducive to improving the income exergy. What’s more, the income exergy of the gas first ascends and then descends with the increase of the flow rate ratio of gas to sinter and the height of the sinter layer. Therefore, optimal values of the flow rate ratio of the gas to sinter and the height of the sinter layer are 1,050–1,540 m3·h−1 and 7–11.5 m within the scope of this study, respectively.
Genetic parameters estimation and genome molecular marker identification for gestation length in pigs
Authors: Shi Lijun , Li Huihui , Wang Lixian 
Published: January 2023

Gestation length (GL) plays an important role in piglet maturation of major organs and development of body, while the genetic molecular markers of GL have not been extensively identified. In this study, according to the 5,662 effective records of 3,072 sows, the heritability and repeatability of GL were estimated through the dmuai of DMU Version 6.5.1 with a repeatability model, namely,h2= 0.1594 andre2= 0.2437. Among these sows, 906 individuals were genotyped with the GeneSeek Genomic Profiler (GGP) Porcine 50K Chip and imputed to the genome-wide level (9,212,179 SNPs) by the online software PHARP v1 for subsequent quality control and GWAS analyses. Further, the Fst was also performed to measure whether the actual frequency of genotypes in different GL phenotypes deviated from the theoretical proportion of genetic balance. We observed the highest degree of differentiation (average Fst value = 0.0376) in the group of 114 and 118 days, and identified a total of 1,002 SNPs strongly associated with GL. Through screening the genes located within a 500 kb distance on either side of the significant SNPs, we proposed 4,588 candidate genes. By the functional annotation, these candidates were found to be mainly involved in multicellular organism metabolism, early endosome, embryo implantation and development, and body and organ signaling pathway. Because of the simultaneous confirmation by GWAS and Fst analyses, there were 20 genes replied to be the most promising candidates includingHUNK,ARHGDIB,ERP27,RERG,NEDD9,TMEM170B,SCAF4,SOD1,TIAM1,ENSSSCG00000048838,ENSSSCG00000047227,EDN1,HIVEP1,ENSSSCG00000043944,LRATD1,ENSSSCG00000048577,ENSSSCG00000042932,ENSSSCG00000041405,ENSSSCG00000045589, andADTRP. This study provided effective molecular information for the genetic improvement of GL in pigs.
CD25 as a unique marker on human basophils in stable-mildly symptomatic allergic asthma
Authors: Iype Joseena , Rohner Lionel , Bachmann Sofia , Hermann Tanja Rahel , Pavlov Nikolay , von Garnier Christophe , Fux Michaela 
Published: January 2023

BackgroundBasophils in acute asthma exacerbation are activated as evidenced by their increased expression levels of activation markers such as CD203c and CD63. However, whether basophils of allergic asthmatics who are in stable phase and have no asthma exacerbations display a specific and distinctive phenotype from those of healthy individuals has yet to be well characterized.ObjectiveWe aimed to identify the phenotype of basophils from allergic asthmatics in the stable phase and investigate whether such a phenotype is affected by ex vivo allergen stimulation.MethodsWe determined by flow cytometry, the expression of surface proteins such as CD25, CD32, CD63, CD69, CD203c, and CD300a and intracellular anti-apoptotic proteins BCL-2, BCL-xL, and MCL-1. We investigated these markers in blood basophils obtained from well-characterized patients with stable-mildly symptomatic form of allergic asthma with no asthma exacerbation and from healthy individuals. Moreover, we determined ex vivo CD63, CD69, and CD25 on blood basophils from stable-mildly symptomatic allergic asthmatics upon allergen stimulation.ResultsIn contrast to all tested markers, CD25 was significantly increased on circulating basophils in the patient cohort with stable-mildly symptomatic allergic asthma than in healthy controls. The expression levels of CD25 on blood basophils showed a tendency to positively correlate with FeNO levels. Notably, CD25 expression was not affected by ex vivo allergen stimulation of blood basophils from stable-mildly symptomatic allergic asthma patients.ConclusionOur data identifies CD25 as a unique marker on blood basophils of the stable phase of allergic asthma but not of asthma exacerbation as mimicked by ex vivo allergen stimulation.
Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma
Authors: Bendavid Guillaume , Hubeau Céline , Perin Fabienne , Gillard Alison , Nokin Marie-Julie , Carnet Oriane , Gerard Catherine , Noel Agnès , Lefebvre Philippe , Rocks Natacha , Cataldo Didier 
Published: January 2023

BackgroundAsthma is characterized by morphological modifications of the airways (inflammation and remodelling) and bronchial hyperresponsiveness. Mechanisms linking these two key features of asthma are still poorly understood. ADAM28 (a disintegrin and metalloproteinase 28) might play a role in asthma pathophysiology. ADAM28 exists as membrane-bound and soluble forms and is mainly expressed by lymphocytes and epithelial cells.MethodsADAM28-/- mice and ADAM28+/+ counterparts were sensitized and exposed to ovalbumin (OVA). Airway responsiveness was measured using the flexiVent® system. After sacrifice, bronchoalveolar lavage (BAL) was performed and lungs were collected for analysis of airway inflammation and remodelling.ResultsThe expression of the soluble form of ADAM28 was lower in the lungs of OVA-exposed mice (as compared to PBS-exposed mice) and progressively increased in correlation with the duration of allergen exposure. In lungs of ADAM28-/- mice exposed to allergens, the proportion of Th2 cells among CD4+ cells and the number of B cells were decreased. Bronchial responsiveness was lower in ADAM28-/- mice exposed to allergens and similar to the responsiveness of sham-challenged mice. Similarly, features of airway remodelling (collagen deposition, smooth muscle hyperplasia, mucous hyperplasia) were significantly less developed in OVA-exposed ADAM28-/- animals in sharp contrasts to ADAM28+/+. In addition, we report the first evidence of ADAM28 RNA expression by lung fibroblasts and we unveil a decreased capacity of lung fibroblasts extracted from OVA-exposed ADAM28-/- mice to proliferate as compared to those extracted from OVA-exposed ADAM28+/+ suggesting a direct contribution of this enzyme to the modulation of airway remodelling.ConclusionThese results suggest that ADAM28 might be a key contributor to the pathophysiology of asthma.
Comprehensive bulk and single-cell transcriptome profiling give useful insights into the characteristics of osteoarthritis associated synovial macrophages
Authors: Liao Shengyou , Yang Ming , Li Dandan , Wu Ye , Sun Hong , Lu Jingxiao , Liu Xinying , Deng Tingting , Wang Yujie , Xie Ni , Tang Donge , Nie Guohui , Fan Xiaoqin 
Published: January 2023

BackgroundOsteoarthritis (OA) is a common chronic joint disease, but the association between molecular and cellular events and the pathogenic process of OA remains unclear.ObjectiveThe study aimed to identify key molecular and cellular events in the processes of immune infiltration of the synovium in OA and to provide potential diagnostic and therapeutic targets.MethodsTo identify the common differential expression genes and function analysis in OA, we compared the expression between normal and OA samples and analyzed the protein–protein interaction (PPI). Additionally, immune infiltration analysis was used to explore the differences in common immune cell types, and Gene Set Variation Analysis (GSVA) analysis was applied to analyze the status of pathways between OA and normal groups. Furthermore, the optimal diagnostic biomarkers for OA were identified by least absolute shrinkage and selection operator (LASSO) models. Finally, the key role of biomarkers in OA synovitis microenvironment was discussed through single cell and Scissor analysis.ResultsA total of 172 DEGs (differentially expressed genes) associated with osteoarticular synovitis were identified, and these genes mainly enriched eight functional categories. In addition, immune infiltration analysis found that four immune cell types, including Macrophage, B cell memory, B cell, and Mast cell were significantly correlated with OA, and LASSO analysis showed that Macrophage were the best diagnostic biomarkers of immune infiltration in OA. Furthermore, using scRNA-seq dataset, we also analyzed the cell communication patterns of Macrophage in the OA synovial inflammatory microenvironment and found that CCL, MIF, and TNF signaling pathways were the mainly cellular communication pathways. Finally, Scissor analysis identified a population of M2-like Macrophages with high expression of CD163 and LYVE1, which has strong anti-inflammatory ability and showed that the TNF gene may play an important role in the synovial microenvironment of OA.ConclusionOverall, Macrophage is the best diagnostic marker of immune infiltration in osteoarticular synovitis, and it can communicate with other cells mainly through CCL, TNF, and MIF signaling pathways in microenvironment. In addition, TNF gene may play an important role in the development of synovitis.
Environmental particle rebound/deposition modeling in engine hot sections
Authors: Jiang Lei-Yong , Trembath Patrick , Patnaik Prakash , Capurro Michele 
Published: January 2023

The aircraft engine hot section is most vulnerable and failure prone to environmental particle ingestion, which, particularly for helicopters, can cause detrimental effects ranging from reduced performance to complete engine failure. The objective of this work is to develop an analytical tool to assess environmental particle impact on engine hot sections. The current state of the art in experimental and analytical research on environmental particle ingestion related to engine hot sections was reviewed, with emphasis on sand particles. From these efforts, the available experimental data for model calibration were identified, and an innovative particle rebound/deposition model has been developed. A semi-empirical approach is selected to model particles bouncing off metal surfaces, where the coefficients of restitution measured in a temperature range of 297–1323 K are used to calculate particle bounce-back velocity components. The developed deposition model is based on non-dimensional parameter analysis over more than seventy experiments related to particle deposition in engine hot sections. The metal surface temperature, one of two critical parameters in particle deposition, is also included in the model. The model was successfully implemented into commercial software and checked step by step. It was calibrated by two cases: sand [Arizona road dust (ARD)] particle impingement on a circular plate and Mt. St. Helens volcanic ash impinging on a first-stage air-cooled nozzle guide vane (NGV). For the former case, the calibrated model predicts fairly well the variation of particle deposition rate with flow/particle temperature. The latter case indicates that the particle deposition rate at engine operating conditions can be assessed by the developed model. Due to the lack of experimental data that would permit a full calibration/validation, for the time being the model can be only used under limited conditions. As additional relevant experimental data appears, the model will be continuously improved.
Monocyte subtype expression patterns in septic patients with diabetes are distinct from patterns observed in obese patients
Authors: Ning Dan , Garg Kunal , Mayer Benjamin , Schick Benedikt , Bracht Hendrik , Barth Eberhard , Weiss Manfred , Li Chen , Schneider Julian , Schneider E. Marion 
Published: January 2023

BackgroundSepsis causes a high rate of mortality and long-term morbidity, associated with an imbalance of innate immunity against infections and inflammation. Obesity and diabetes increase the risk for disease severity. Monocyte dysfunction plays a major role and justify further investigations.ObjectiveTo investigate the distribution and inflammatory phenotypes in circulating monocyte subsets in patients manifesting with sepsis including septic shock with and without obesity and diabetes.MethodsA total of 235 blood samples were tested from critically ill adult patients registered at the intensive care unit (ICU). The cohorts were divided into non-diabetic groups with or without obesity and diabetic groups with or without obesity, suffering from sepsis or septic shock. We determined frequencies of total monocytes and of monocyte subsets in the circulation and density expression levels of functional markers, including CD14, CD16, HLA-DR, CD33, CD163, CD206, and arginase-1 by flow cytometric analysis.ResultsWhen progressing to septic shock in non-diabetic and diabetic patients, the percentages of total monocytes among the leukocyte population and of CD33+ and CD14+ monocytes among the monocyte population were consistently down-regulated compared to non-sepsis in non-diabetic and diabetic patients, respectively. Non-diabetic sepsis patients further presented with decreased CD33 and up-regulated CD163 expression density, which was absent in diabetic patients. We subsequently addressed obesity-related changes of monocytes in non-diabetic and diabetic septic patients. Obese septic patients with diabetes were unique in displaying increased monocytic CD16 and CD163 expression. However, obese septic patients without diabetes solely presented with lower amounts of non-classical monocytes. Body mass index (BMI) dependent changes were restricted to diabetic septic patients, with a significantly higher diminution of the classical monocyte subset and concomitantly increased CD16 expression densities.ConclusionDistribution and phenotypes of monocyte subsets were differentially modulated in critically ill patients with and without metabolic disease when progressing to sepsis or septic shock. Only diabetic septic patients displayed decline of classical monocytes and increase of CD16 expression densities. Therefore, diabetes but not obesity appears to promote the inflammatory phenotype of circulating monocytes in critically ill patients.
Enrichment of dementia caregiving relationships through psychosocial interventions: A scoping review
Authors: Hoel Viktoria , Koh Wei Qi , Sezgin Duygu 
Published: January 2023

ObjectivesEnrichment, defined as “the process of endowing caregiving with meaning or pleasure for both the caregiver and care recipient” can support relationships between people living with dementia (PLWD) and their caregivers. This study aims to explore (1) the types of psychosocial interventions that may enrich relationships between dementia caregiving dyads, and (2) the components within these psychosocial interventions that may contribute to enrichment.MethodsA scoping review was conducted based on the Joanna Briggs Institute framework. We operationalized and contextualized core elements from Cartwright and colleagues’ enrichment model, which was also used to guide the review. Five electronic databases were searched. Psychosocial intervention components contributing to enrichment were identified and grouped within each core element.ResultsThirty-four studies were included. Psychosocial interventions generating enrichment among dyads mainly involved supporting dyadic engagement in shared activities, carer education or training, or structural change to the environment around PLWD. Intervention components contributing to the enrichment of dyadic relationships were identified within “acquired symbolic meaning”, “performing activity”, and “fine tuning”. Dyadic communication support and skill-building were common contributors to enrichment.ConclusionOur findings may inform the planning and development of interventions to enrich dyadic relationships in the context of dementia. In formal caregiving contexts, future interventions may consider dedicating space for relationships to build and grow through positive interactions. In informal caregiving contexts, existing relationships should be considered to better support dyads engage in positive interactions.