bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impulsive choice in individuals with comorbid amphetamine use disorder and attention deficit-hyperactivity disorder
Authors: Brynte Christoffer , Khemiri Lotfi , Stenström Hannes , Konstenius Maija , Lindström Nitya-Jayaram , Franck Johan 
Published: July 2023

Abstract
Background
Amphetamine use disorder (AMPH) and attention deficit-hyperactivity disorder (ADHD) often co-occur and are associated with poor treatment outcomes. Elevated impulsivity is a core feature in both disorders. Little is known however about the specific neurocognitive profile regarding different facets of impulsivity, and specifically impulsive choice, in comorbid populations.

Methods
Three groups (ADHD + AMPH, ADHD only and healthy controls (HC)) were assessed with self-reported impulsivity and cognitive tasks of impulsive choice, operationalized as delay aversion (DA) and reflection impulsivity.

Results
Twenty-nine participants with comorbid ADHD + AMPH, 25 participants with ADHD only and 116 HC completed screening, including self-rating scales, and cognitive testing. 20, 16 and 114 participants completed computerized cognitive tasks in the ADHD + AMPH group, ADHD group and HC group, respectively. The ADHD + AMPH group reported significantly higher motor, attentional and non-planning impulsiveness, and showed a significantly higher degree of impulsive choice, compared to both groups. There were no differences in task-related impulsiveness between ADHD only and HC.

Conclusions
The current findings suggest that individuals with ADHD + AMPH have overall elevated levels of impulsivity compared to individuals with ADHD only. In addition, that ADHD + AMPH is specifically associated with impairments in task-related impulsive choice, which was not found in ADHD only compared to HC. The neurocognitive profile in this specific patient group may represent a need for more systematic screening within healthcare settings in order to develop effective and targeted treatment for comorbid patients.

Trial registration
EudraCT, 2012–004298-20.
Effects of a multi-component alcohol prevention program in the workplace on hazardous alcohol use among employees
Authors: Elling Devy L. , Almquist Ylva B. , Wennberg Peter , Sundqvist Kristina 
Published: July 2023

Abstract
Background
The workplace can be affected negatively by hazardous alcohol use, and intervening at an early stage remains a challenge. Recently, a multi-component alcohol prevention program, Alcohol Policy and Managers’ skills Training (hereafter, ‘APMaT’), was delivered at the organizational level. In a previous outcome evaluation, APMaT appeared to be effective at the managerial level. The current study takes a step further by aiming to evaluate the effectiveness of APMaT in decreasing the alcohol risk level among employees.

Methods
Data from 853 employees (control: n = 586; intervention: n = 267) were gathered through a cluster-randomized study. To analyze changes in the odds of hazardous alcohol use among employees, multilevel logistic regression was applied using group (control vs. intervention), time (baseline vs. 12-month follow-up), and the multiplicative interaction term (group × time) as the main predictors. The intervention effect was further adjusted for sociodemographic characteristics and policy awareness.

Results
No statistically significant difference was observed in the odds of hazardous alcohol use, although employees in the intervention group showed a larger decrease compared to the control group. This remained even after adjusting for several factors, including the sociodemographic factors and policy awareness.

Conclusions
The findings are insufficient to determine the effectiveness of APMaT at the employee level at the current stage of the evaluation. Future studies should strive to identify issues with implementation processes in workplace-based alcohol interventions.

Trial registration
The trial was retrospectively registered on 11/10/2019; ISCRTN ID: ISRCTN17250048.
The perceptions and experience of developing patient (version of) guidelines: a descriptive qualitative study with Chinese guideline developers
Authors: Yan Lijiao , Hu Jiale , Yu Zeyu , Li Shelly-Anne , Graham Karen , Scott Sarah E. , Shen Chen , Jin Xuejing , Liu Jianping 
Published: July 2023

Abstract
Objective
To understand developers’ perception of patient (versions of) guidelines (PVGs), and identify challenges during the PVG development, with the aim to inform methodological guidance for future PVG development.

Methods
We used a descriptive qualitative design. Semi-structured interviews were conducted virtually from December 2021 to April 2022, with a purposive sampling of 12 PVG developers from nine teams in China. Conventional and directed content analysis was used for data analysis.

Results
The interviews identified PVG developers’ understanding of PVGs, their current practice experience, and the challenges of developing PVGs. Participants believed PVGs were a type of health education material for patients; therefore, it should be based on patient needs and be understandable and accessible. Participants suggested that PVGs could be translated/adapted from one or several clinical practice guidelines (CPG), or developed de novo (i.e., the creation of an entirely new PVG with its own set of research questions that are independent of existing CPGs). Participants perceived those existing methodological guidelines for PVG development might not provide clear instructions for PVGs developed from multiple CPGs and from de novo development. Challenges to PVG development include (1) a lack of standardized and native guidance on developing PVGs; (2) a lack of standardized guidance on patient engagement; (3) other challenges: no publicly known and trusted platform that could disseminate PVGs; concerns about the conflicting interests with health professionals.

Conclusions and practice implications
Our study suggests clarifying the concept of PVG is the primary task to develop PVGs and carry out related research. There is a need to make PVG developers realize the roles of PVGs, especially in helping decision-making, to maximize the effect of PVG. It is necessary to develop native consensus-based guidance considering developers’ perspectives regarding PVGs.
The current status of surgical care in the Asia–Pacific region and opportunities for improvement: proceedings
Authors: Qin Rennie X. , Fowler Zachary G. , Jayaram Anusha , Stankey Makela , Yoon Sangchul , McLeod Elizabeth , Park Kee B. 
Published: July 2023

AbstractThe World Health Assembly resolution 68.15 recognised emergency and essential surgery as a critical component of universal health coverage. The first session of the three-part virtual meeting series on Strategic Planning to Improve Surgical, Obstetric, Anaesthesia, and Trauma Care in the Asia–Pacific Region focused on the current status of surgical care and opportunities for improvement. During this session, Ministries of Health and World Health Organization (WHO) Regional Directors shared country- and regional-level progress in surgical system strengthening. The WHO Western Pacific Regional Office (WPRO) has developed an Action Framework for Safe and Affordable Surgery, whilst the WHO South-East Asia Regional Office (SEARO) highlighted their efforts in emergency obstetric care, workforce strengthening, and blood safety. Numerous countries have begun developing and implementing National Surgical, Obstetric, and Anaesthesia Plans (NSOAPs). Participants agreed surgical system strengthening is an integral component of universal health coverage, pandemic preparedness, and overall health system resilience. Participants discussed common challenges, such as the COVID-19 pandemic, climate change, workforce capacity building, and improving access for hard-to-reach populations. They generated and shared common solutions, including strengthening surgical care capacity in first-level hospitals, anaesthesia task-shifting, remote training, and integrating surgical care with public health, preventive care, and emergency preparedness. Moving forward, participants committed to developing and implementing NSOAPs and agreed on the need to raise political awareness, build a broad-based movement, and form intersectoral collaborations.
Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma
Authors: Gautam Shailendra K. , Batra Surinder K. , Jain Maneesh 
Published: July 2023

AbstractImmunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC), contributing to early metastasis and poor patient survival. Compared to the localized tumors, current standard-of-care therapies have failed to improve the survival of patients with metastatic PDAC, that necessecitates exploration of novel therapeutic approaches. While immunotherapies such as immune checkpoint blockade (ICB) and therapeutic vaccines have emerged as promising treatment modalities in certain cancers, limited responses have been achieved in PDAC. Therefore, specific mechanisms regulating the poor response to immunotherapy must be explored. The immunosuppressive microenvironment driven by oncogenic mutations, tumor secretome, non-coding RNAs, and tumor microbiome persists throughout PDAC progression, allowing neoplastic cells to grow locally and metastasize distantly. The metastatic cells escaping the host immune surveillance are unique in molecular, immunological, and metabolic characteristics. Following chemokine and exosomal guidance, these cells metastasize to the organ-specific pre-metastatic niches (PMNs) constituted by local resident cells, stromal fibroblasts, and suppressive immune cells, such as the metastasis-associated macrophages, neutrophils, and myeloid-derived suppressor cells. The metastatic immune microenvironment differs from primary tumors in stromal and immune cell composition, functionality, and metabolism. Thus far, multiple molecular and metabolic pathways, distinct from primary tumors, have been identified that dampen immune effector functions, confounding the immunotherapy response in metastatic PDAC. This review describes major immunoregulatory pathways that contribute to the metastatic progression and limit immunotherapy outcomes in PDAC. Overall, we highlight the therapeutic vulnerabilities attributable to immunosuppressive factors and discuss whether targeting these molecular and immunological “hot spots” could improve the outcomes of PDAC immunotherapies.
Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering
Authors: Chen Kai , Li Yonghui , Li Youbin , Tan Yinfeng , Liu Yingshuo , Pan Weisan , Tan Guoxin 
Published: July 2023

AbstractThe stimuli-responsive nanofibers prepared by electrospinning have become an ideal stimuli-responsive material due to their large specific surface area and porosity, which can respond extremely quickly to external environmental incitement. As an intelligent drug delivery platform, stimuli-responsive nanofibers can efficiently load drugs and then be stimulated by specific conditions (light, temperature, magnetic field, ultrasound, pH or ROS, etc.) to achieve slow, on-demand or targeted release, showing great potential in areas such as drug delivery, tumor therapy, wound dressing, and tissue engineering. Therefore, this paper reviews the recent trends of stimuli-responsive electrospun nanofibers as intelligent drug delivery platforms in the field of biomedicine.
Initial validation of the Multidimensional Adolescent Functioning Scale (MAFS) in Spanish-speaking students from Chilean secondary schools
Authors: Núñez Daniel , Villacura-Herrera César , Gaete Jorge , Meza Daniela , Andaur Javiera , Wigman Johanna T.W. , Robinson Jo 
Published: July 2023

Abstract
Introduction
Psychosocial functioning is closely associated with psychopathology and wellbeing in different populations, particularly adolescents. Despite its relevance, measures assessing psychosocial functioning in healthy adolescents are scant as most focus on adults or clinical populations. We evaluated the psychometric properties of the Multidimensional Adolescent Functioning Scale (MAFS), a self-report questionnaire created to assess three dimensions of psychosocial functioning (‘general functioning’, ‘family-related functioning’, and ‘peer-related functioning’) in adolescents from the general population.

Methods
After translation and cultural adaptation, we administered the Spanish MAFS to 619 adolescents aged 14 to 19. We assessed the factor structure, internal consistency, and associations with depressive symptoms, suicidal ideation, cognitive-behavioral skills, cognitive reappraisal (CR), and expressive suppression (ES). We additionally tested for measurement invariance based on biological sex.

Results
The original three-factor structure showed the best fit. Internal consistency was good for the total scale (ω = 0.874; α = 0.869; GLB = 0.939, rM=0.216) and for all subscales (ω = 0.806-0.839; α = 0.769 to 0.812; GLB = 0.861-0.873). Correlations between all three MAFS subscales were significant, ranging between 0.291 and 0.554. All MAFS subscales correlated positively and significantly with cognitive-behavioral skills and adaptive regulatory strategies and negatively with depressive symptoms and suicidal ideation.

Conclusion
The Spanish MAFS translation is a valid and reliable self-report measure to assess three domains of psychosocial functioning in adolescents aged 14–19 from the general population.
Rural research capacity: a co-created model for research success
Authors: Farris Paige , Crist Rachel , Miller Sylvia , Shannon Jackilen 
Published: July 2023

Abstract
Purpose
The United States’ National Institutes of Health (NIH) have long challenged academia to improve clinical trial enrollment, especially in underrepresented populations; inclusive of geography, age, disability status, racial and ethnic minorities. It has been shown that rural and urban residents enrolled in clinical trials have similar outcomes, yet, rural healthcare systems struggle to provide opportunities to rural residents to participate in clinical trials when infrastructure is limited or unsupportive of research programs and/or research staffing levels are insufficient. To fully address the barriers to clinical trial access in rural areas, it is not adequate to simply open more trials. Community receptivity of research as well as organizational and community capacity must be considered. This project was determined by the Oregon Health and Science University’s Institutional Review Board to be generalizable research across the chosen counties and was approved to operate under a waiver of written consent. Participants received a cash incentive in appreciation for their time and verbally agreed to participate after reviewing a project information sheet.

Methods
The research team co-created a community-responsive approach to the receipt, review, and acceptance of clinical trials in a rural community setting. An adapted 5 step Implementation Mapping approach was used to develop a systematic strategy intended to increase the success, and therefore, the number of clinical trials offered in a rural community.

Results
The research team and participating rural community members pilot-tested the implementation of a co-designed research review strategy, inclusive of a Regional Cultural Landscape and three co-created project submission and feasibility review forms, with a cancer early detection clinical trial. The proposed clinical trial required engagement from primary care and oncology. Utilizing the research review strategy demonstrated strong researcher-community stakeholder communication and negotiation, which resulted in early identification and resolution of potential barriers, hiring a local clinical research coordinator, and timely trial opening.

Conclusion
To the knowledge of the research team, the work described is the first to use a community-engaged approach for creating a clinical trial implementation strategy directly supportive of rural-sitting community stakeholders in receiving, reviewing, and approving cancer-related clinical trials in their community. Participating community members and leaders had the chance to negotiate research protocol changes or considerations directly with researchers interested in conducting a cancer clinical trial in their rural setting.
Genetic history of East-Central Europe in the first millennium CE
Authors: Stolarek Ireneusz , Zenczak Michal , Handschuh Luiza , Juras Anna , Marcinkowska-Swojak Malgorzata , Spinek Anna , Dębski Artur , Matla Marzena , Kóčka-Krenz Hanna , Piontek Janusz ,   Polish Archaeogenomics Consortium Team, Figlerowicz Marek 
Published: July 2023

Abstract
Background
The appearance of Slavs in East-Central Europe has been the subject of an over 200-year debate driven by two conflicting hypotheses. The first assumes that Slavs came to the territory of contemporary Poland no earlier than the sixth century CE; the second postulates that they already inhabited this region in the Iron Age (IA). Testing either hypothesis is not trivial given that cremation of the dead was the prevailing custom in Central Europe from the late Bronze Age until the Middle Ages (MA).

Results
To address this problem, we determined the genetic makeup of representatives of the IA Wielbark- and MA Slav-associated cultures from the territory of present-day Poland. The study involved 474 individuals buried in 27 cemeteries. For 197 of them, genome-wide data were obtained. We found close genetic affinities between the IA Wielbark culture-associated individuals and contemporary to them and older northern European populations. Further, we observed that the IA individuals had genetic components which were indispensable to model the MA population.

Conclusions
The collected data suggest that the Wielbark culture-associated IA population was formed by immigrants from the north who entered the region of contemporary Poland most likely at the beginning of the first millennium CE and mixed with autochthons. The presented results are in line with the hypothesis that assumes the genetic continuation between IA and MA periods in East-Central Europe.
Mad2 is dispensable for accurate chromosome segregation but becomes essential when oocytes are subjected to environmental stress
Authors: Qiao Jing-Yi , Zhou Qian , Xu Ke , Yue Wei , Lei Wen-Long , Li Yuan-Yuan , Gu Lin-Jian , Ouyang Ying-Chun , Hou Yi , Schatten Heide , Meng Tie-Gang , Wang Zhen-Bo , Sun Qing-Yuan 
Published: July 2023

ABSTRACT
Accurate chromosome segregation, monitored by the spindle assembly checkpoint (SAC), is crucial for the production of euploid cells. Previous in vitro studies by us and others showed that Mad2, a core member of the SAC, performs a checkpoint function in oocyte meiosis. Here, through an oocyte-specific knockout approach in mouse, we reconfirmed that Mad2-deficient oocytes exhibit an accelerated metaphase-to-anaphase transition caused by premature degradation of securin and cyclin B1 and subsequent activation of separase in meiosis I. However, it was surprising that the knockout mice were completely fertile and the resulting oocytes were euploid. In the absence of Mad2, other SAC proteins, including BubR1, Bub3 and Mad1, were normally recruited to the kinetochores, which likely explains the balanced chromosome separation. Further studies showed that the chromosome separation in Mad2-null oocytes was particularly sensitive to environmental changes and, when matured in vitro, showed chromosome misalignment, lagging chromosomes, and aneuploidy with premature separation of sister chromatids, which was exacerbated at a lower temperature. We reveal for the first time that Mad2 is dispensable for proper chromosome segregation but acts to mitigate environmental stress in meiotic oocytes.
Oczami kobiet – „Mój sierpień ’80. Pamiętne lato” i „Mój sierpień „80” – źródła do badań nad historią wydarzeń Grudnia’ 70 oraz strajku Stoczni Gdańskiej w 1980 r.
Authors: Kosk Barbara 
Published: July 2023

Prezentowany tekst stanowi edycję źródeł zatytułowanych „Mój sierpień ’80. Pamiętne lato” oraz „Mój Sierpień „80”. Powyższe materiały nadesłano na konkurs zorganizowany w 1981 roku przez Oddział Gdański Polskiego Towarzystwa Socjologicznego poświęcony relacjom z protestu, który wybuchł na Wybrzeżu latem 1980 roku. Edycji dokonano na podstawie instrukcji wydawniczej Janusza Tandeckiego oraz Krzysztofa Kopińskiego pod tytułem „Edytorstwo źródeł historycznych”. Tekst opatrzono wstępem, w którym przedstawiono najważniejsze informacje dotyczące sierpniowej fali sprzeciwu. Cel prezentowanych edycji stanowi ukazanie wspomnień Haliny Pawłowskiej oraz Marty Wiśniewskiej, które stanowią źródło do badań nad historią wydarzeń Grudnia ’70 i strajku sierpniowego. Przedstawione relacje, widziane w perspektywie kobiet przybyłych na Wybrzeże ze stolicy kraju, ukazują odmienne niż powszechnie prezentowane w literaturze przedmiotu spojrzenie na wydarzenia mające miejsce w Trójmieście.
Semiotics analysis on “Samsung x BTS: Galaxy for the Planet” Advertisement
Authors: Vidiyawati Anisa Viyata Suci , Wibowo | SINTA ID: 6679378 Arif Ardy 
Published: July 2023

This paper aim to analyze the message from the Samsung x BTS Ads: Galaxy for the planet. Global warming is a form of ecosystem imbalance on earth due to increasing the average temperature of the atmosphere, sea, and land on earth. Samsung and BTS works together in this Ads to show some concern about environment. This research uses descriptive qualitative type. The qualitative descriptive method is a research method based on the post-positivism philosophy. Therefore, researchers have analyzed objects and examined each icon, indexical, and symbol to be observed with three aspects of Pierce's Object theory. According to Pierce, semiotics is a science that discusses signs and the production of their meanings. At this stage, the researcher will discuss the results and research data regarding the problems described, namely the Semiotic Analysis of Samsung x BTS: Galaxy for the Planet advertisements. This advertisement has meaning and message to change people's mindset towards the earth to be more concerned about the environment. This ad also displays symbols and signs. As an electronic brand, Samsung pays more attention to the surrounding environment by using recycled material to minimize environmental impact and carefully chooses its brand ambassador to add value to its ads.
What's the deal? the importance of asking about recreational drug use in dental settings
Authors: Mudhar Onkar , Bradley Natalie , Samuel Megan 
Published: July 2023

This article looks at the dental implications of the most commonly abused recreational drugs in the UK. It emphasizes the need for clinicians to have honest discussions with their patients and obtain this often overlooked piece of information. We discuss not only the oral manifestations and health implications of various recreational drugs, but also the impacts their use may have on a range of dental treatment. Furthermore, tips are given on how to obtain this often sensitive information. CPD/Clinical Relevance: The use of recreational drugs has oral health implications and may impact on a range of dental treatment.
O legado sertanejo presente na obra do artista Juraci Dórea
Authors: Rizolane Soares de Oliveira Brito  
Published: July 2023

Pretende-se relacionar a obra do artista Juraci Dórea com a cultura sertaneja, o patrimônio cultural e o legado educacional, fazendo uma relação entre obra, artista e contexto histórico da guerra de Canudos. Nesta pesquisa elegeu-se uma série de pinturas de Dórea que integra o Projeto Canudos, desenvolvido em 1990, em parceria com o artista Washington Falcão.
Seu trabalho parte de suas vivências e lembranças dos sertões, às quais se somam fontes diversas, como a história oral, conversas com sobreviventes da guerra e referências bibliográficas, com destaque para Os Sertões, de Euclides da Cunha, além do vasto acervo fotográfico do período da guerra.