bluuebunny/crossref_metadata_2025_split huggingface dataset:
On n-Jordan homoderivations in rings
Authors: Belkadi Said , Ali Shakir , Taoufiq Lahcen 
Published: August 2023

Abstract
Let R be a ring and let

n
≥
1

{n\geq 1}

be a fixed integer. An additive mapping h of a ring R into itself is called an n-Jordan homoderivation if

h
⁢

(

x
n

)

=

(

h
⁢

(
x
)

+
x

)

n

-

x
n

{h(x^{n})=(h(x)+x)^{n}-x^{n}}

holds for all

x
∈
R

{x\in R}

. In this paper, we initiate the study of n-Jordan homoderivations on rings. Precisely, we characterize n-Jordan homoderivations in terms of homoderivations and anti-homomorphisms under certain conditions. Finally, we conclude our paper with a direction for further research.
Risk model and validation of carbapenem-resistant Klebsiella pneumoniae infection in patients with cerebrovascular disease in the ICU
Authors: Liao Qiuxia , Feng Zhi , Chen Xiaoli 
Published: August 2023

Abstract
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an emerging global epidemic. The intention of this study was to explore the risk model and validation of CRKP infection in patients with cerebrovascular disease in the intensive care unit (ICU). The data of patients with cerebrovascular disease and Klebsiella pneumoniae infection were retrospectively collected. The patients were divided into the CRKP group and the carbapenem-susceptible Klebsiella pneumoniae (CSKP) group. There were significant differences (P < 0.05) between the CRKP group and the CSKP group for many variables. Multivariate binary logistic regression analysis showed that the number of types of antibiotics used, history of glucocorticoid use, and duration of mechanical ventilation before the occurrence of infectious bacteria are the independent risk factors for CRKP infection in patients with cerebrovascular disease in the ICU, and a nomogram risk model was constructed accordingly. The area under the ROC curve of the risk model was 0.868 (95% CI: 0.803–0.934).
Leadership in the Emergent Baekje State: State Formation in Central-Western Korea (ca. 200–400 CE)
Authors: Kim Minkoo 
Published: August 2023

Abstract
The process of state formation is a social phenomenon closely connected with a polity’s external relationships. During peer–polity interactions, polities undergo social reorganization as they mutually influence each other. This study examines this process and argues that in central-western Korea, around 200–400 CE, hostile interactions among multiple polities weakened the power of ingroup members to level social differences and increased social complexity. When confronted with unfriendly outgroups, potential rulers could assume different social roles (e.g., diplomat, war leader, or trader) and utilize new social threats to demand and legitimize higher social status. Archaeological data from central-western Korea illustrate the community’s efforts to build a defense system and prepare for war. Autonomous agricultural communities rapidly realigned into a state system in response to external threats, presumably from historically documented hostile groups such as the Lelang commandery and Goguryeo. The decision to oppose neighboring polities likely enhanced the leaders’ ability to consolidate power, while the rulers of the Baekje (also spelled “Paekche”) state could employ various other means for self-aggrandizement throughout its history.
pH-Dependent Leaching Characteristics of Steel Slag Mitigated with Water Treatment Residual
Authors: Dayioglu Asli Y. 
Published: August 2023

Abstract
Steel slag (S) is a by-product of the steel industry with an annual global production of 280 MMT. A significant amount of the S is landfilled, causing economic loss and waste of valuable land space. S is deemed to have great potential as an aggregate because of its mechanical properties; however, the high swelling potential and alkalinity caused by large amounts of free calcium, hence the risk for metal leaching, limit its utilization; thus, a pretreatment process is needed. Amending the S with alum-based water treatment residual (WTR), which may form insoluble complexes with the free calcium, is expected to yield successful results, yet the leaching behavior and controlling mechanisms need to be determined. This study aims to evaluate the pH-dependent leaching characteristics of the pure and WTR-treated S as well as determine the dominant oxidation states of the trace metals and the controlling mechanisms. Acid neutralization capacity and pHstat leaching tests were performed on S–WTR mixtures with WTR contents varying from 0 to 100 % at a pH range of 2 to 14. The tests showed that leaching of all metals is significantly affected by pH and WTR content. Aluminum and copper exhibit an amphoteric behavior in which minimum leaching is observed at the neutral pH values and the metal concentrations are elevated at extreme acidic and alkaline pHs. On the other hand, cadmium, magnesium, calcium, and barium show a cationic leaching pattern. Furthermore, geochemical analyses were undertaken via Visual MINTEQ to determine predominant oxidation states of the metals with a redox potential and the speciation within the aqueous solutions, which showed that most of the releases from the elements were solubility controlled.
Multimodal Imaging for Validation and Optimization of Ion Channel-Based Chemogenetics in Nonhuman Primates
Authors: Hori Yuki , Nagai Yuji , Hori Yukiko , Oyama Kei , Mimura Koki , Hirabayashi Toshiyuki , Inoue Ken-ichi , Fujinaga Masayuki , Zhang Ming-Rong , Takada Masahiko , Higuchi Makoto , Minamimoto Takafumi 
Published: August 2023

Chemogenetic tools provide an opportunity to manipulate neuronal activity and behavior selectively and repeatedly in nonhuman primates (NHPs) with minimal invasiveness. Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are one example that is based on mutated muscarinic acetylcholine receptors. Another channel-based chemogenetic system available for neuronal modulation in NHPs uses pharmacologically selective actuator modules (PSAMs), which are selectively activated by pharmacologically selective effector molecules (PSEMs). To facilitate the use of the PSAM/PSEM system, the selection and dosage of PSEMs should be validated and optimized for NHPs. To this end, we used a multimodal imaging approach. We virally expressed excitatory PSAM (PSAM4-5HT3) in the striatum and the primary motor cortex (M1) of two male macaque monkeys, and visualized its location through positron emission tomography (PET) with the reporter ligand [18F]ASEM. Chemogenetic excitability of neurons triggered by two PSEMs (uPSEM817 and uPSEM792) was evaluated using [18F]fluorodeoxyglucose-PET imaging, with uPSEM817 being more efficient than uPSEM792. Pharmacological magnetic resonance imaging (phMRI) showed that increased brain activity in the PSAM4-expressing region began ∼13 min after uPSEM817 administration and continued for at least 60 min. Our multimodal imaging data provide valuable information regarding the manipulation of neuronal activity using the PSAM/PSEM system in NHPs, facilitating future applications.SIGNIFICANCE STATEMENTLike other chemogenetic tools, the ion channel-based system called pharmacologically selective actuator module/pharmacologically selective effector molecule (PSAM/PSEM) allows remote manipulation of neuronal activity and behavior in living animals. Nevertheless, its application in nonhuman primates (NHPs) is still limited. Here, we used multitracer positron emission tomography (PET) imaging and pharmacological magnetic resonance imaging (phMRI) to visualize an excitatory chemogenetic ion channel (PSAM4-5HT3) and validate its chemometric function in macaque monkeys. Our results provide the optimal agonist, dose, and timing for chemogenetic neuronal manipulation, facilitating the use of the PSAM/PSEM system and expanding the flexibility and reliability of circuit manipulation in NHPs in a variety of situations.
Signatures of Electrical Stimulation Driven Network Interactions in the Human Limbic System
Authors: Ojeda Valencia Gabriela , Gregg Nicholas M. , Huang Harvey , Lundstrom Brian N. , Brinkmann Benjamin H. , Pal Attia Tal , Van Gompel Jamie J. , Bernstein Matt A. , In Myung-Ho , Huston John , Worrell Gregory A. , Miller Kai J. , Hermes Dora 
Published: August 2023

Stimulation-evoked signals are starting to be used as biomarkers to indicate the state and health of brain networks. The human limbic network, often targeted for brain stimulation therapy, is involved in emotion and memory processing. Previous anatomic, neurophysiological, and functional studies suggest distinct subsystems within the limbic network (Rolls, 2015). Studies using intracranial electrical stimulation, however, have emphasized the similarities of the evoked waveforms across the limbic network. We test whether these subsystems have distinct stimulation-driven signatures. In eight patients (four male, four female) with drug-resistant epilepsy, we stimulated the limbic system with single-pulse electrical stimulation. Reliable corticocortical evoked potentials (CCEPs) were measured between hippocampus and the posterior cingulate cortex (PCC) and between the amygdala and the anterior cingulate cortex (ACC). However, the CCEP waveform in the PCC after hippocampal stimulation showed a unique and reliable morphology, which we term the “limbic Hippocampus-Anterior nucleus of the thalamus-Posterior cingulate, HAP-wave.” This limbic HAP-wave was visually distinct and separately decoded from the CCEP waveform in ACC after amygdala stimulation. Diffusion MRI data show that the measured end points in the PCC overlap with the end points of the parolfactory cingulum bundle rather than the parahippocampal cingulum, suggesting that the limbic HAP-wave may travel through fornix, mammillary bodies, and the anterior nucleus of the thalamus (ANT). This was further confirmed by stimulating the ANT, which evoked the same limbic HAP-wave but with an earlier latency. Limbic subsystems have unique stimulation-evoked signatures that may be used in the future to help network pathology diagnosis.SIGNIFICANCE STATEMENTThe limbic system is often compromised in diverse clinical conditions, such as epilepsy or Alzheimer’s disease, and characterizing its typical circuit responses may provide diagnostic insight. Stimulation-evoked waveforms have been used in the motor system to diagnose circuit pathology. We translate this framework to limbic subsystems using human intracranial stereo EEG (sEEG) recordings that measure deeper brain areas. Our sEEG recordings describe a stimulation-evoked waveform characteristic to the memory and spatial subsystem of the limbic network that we term the “limbic HAP-wave.” The limbic HAP-wave follows anatomic white matter pathways from hippocampus to thalamus to the posterior cingulum and shows promise as a distinct biomarker of signaling in the human brain memory and spatial limbic network.
Digital Civility Transition Practices by Academic Community During COVID-19 Pandemic
Authors: Putra Romeyn Perdana , Egabetha Amirah Yudhaputri  , Eviana Rosida  , Diah Arli  
Published: August 2023

The digital revolution, huge changes, and digital disruption, amplified by the Covid-19 pandemic, prompted digital natives and digital immigrants to implement distance learning. Some institutions develop new learning management systems to support online learning, and also monitor academic activities such as student college attendance, posting examination case studies, and integrating exam results into student information systems. In contrast, all university members (lecturers, student college, and course management corporate) still have obstacles to using this student information system. The system implementation is unfamiliar for most members at first. Furthermore, this research is used as a qualitative method through a forum group discussion involving lecturers and student colleges of six (6) cities in Indonesia. While it is taking place in an online class, the potential risks of being exposed to electronic influences are getting more delicate.
Keywords: digital civility, distance learning ethics, risks of being exposed to online impacts, online campus
Manajemen Produksi Konten YouTube Danang Giri Sadewa
Authors: Ihsan Rifki , Wijayanto Ari , Nur Hidayat Irfan 
Published: August 2023

Channel Youtube Danang Giri Sadewa merupakan salah satu konten kreator yang membahas tentang dunia mahasiswa hingga tour kampus. Penelitian ini befokus tentang tentang bagaimana proses produksi dan perkembangan konten Youtube Danang Giri Sadewa. Pertanyaan penelitian ini berkisar pada proses produksi atau pengembangan konten yang dilakukan Channel Youtube Danang Giri Sadewa. rumusan penelitian ini adalah bagaimana manajemen produksi dan perkembangan konten Youtube Danang Giri Sadewa ? beranjak dari rumusan masalah diatas, maka tujuan dari penelitian ini adalah mengetahui tentang bagaimana proses produksi dan perkembangan konten Youtube Danang Giri Sadewa. Pertanyaan penelitian ini berkisar pada proses produksi atau pengembangan konten yang dilakukan Channel Youtube Danang Giri Sadewa. Penelitian ini mengacu pada metode penelitian deskriptif kualitatif bertujuan untuk menjelaskan secara umum manajerial dalam proses produksi konten dengan sumber data wawancara. Temuan penelitian ini yaitu adanya proses yang cukup panjang untuk memproduksi konten Youtube dari mulai pra produksi, produksi, hingga post produksi. Ketiga alur tersebut juga memiliki tahapan tahapan sehingga proses pembuatanya lebih terstruktur dan termanajemen dengan baik.
Primary ovarian insufficiency- an overview: Part 1 definition, arteriology, clinical relevance
Authors: Mondal Rana , Nandi Mouli , Mandal Priyadarshi 
Published: August 2023

Loss of normal ovarian function before the age of 40 characterizes primary ovarian insufficiency (POI), sometimes called premature ovarian failure or early menopause. Many women all around the globe deal with this serious reproductive health issue. The purpose of this study is to provide a broad perspective on how to identify and treat primary ovarian insufficiency. Symptoms, hormone profiles, and ovarian imaging help diagnose POI. Genetics, autoimmune illness, and medical intervention may cause it. After a proper diagnosis, affected women might get counselling and therapy.This review article covers primary ovarian insufficiency diagnosis and treatment. Affected women should be diagnosed early, counselled, and treated individually. Understanding POI and developing better drugs may improve these people's reproductive and general health.
Role of PPH clamp as a first aid in management of PPH in central India population
Authors: Singh Kirti , Soni Khushboo , Golhani Pallavi 
Published: August 2023

PPH is most significant and common cause of maternal morbidity and mortality in developing and developed countries both due to uncontrolled bleeding. It is responsible for 30% of maternal death. Around, two-thirds of the obstetric morbidity is related to haemorrhage. From many studies, found that PPH 50 times increases the risk of the morbidity and 5 times higher morbidity than mortality.: This is a prospective cohort study, which is done in the Department of Obstetrics & Gynaecology of MGM Medical College and M.Y. Hospital, Indore over a period of one year in 60 patients.All the patients who developed PPH with failed medical management and give proper consent for application of clamp included. Patients with cervical cancer and patients who do not give consent are excluded.: All the data analysis was performed using IBM SPSS ver. 20 software. Frequency tables and cross tabulation is used to prepare the tables. Categorical data was expressed as number and percentages whereas quantitative data was expressed as mean and standard deviation. Categorical data was compared using chi square test whereas means were compared using one-way Anova. Microsoft word and excel used to generate graph, table etc. P value of less than 0.05 was considered as significant. In our study, more than half (56.7%) clamping were successful. In this study, more than half (56.7%) clamping were successful. Patients with lower parity had more chances of successful clamp as compared with those with higher parity. Blood loss was significantly less in those with successful clamp (1127.94) as compared to without successful clamp (1384.62) as revealed by the highly significant p value of &#60;0.001.In the present study, we evaluated requirement of further surgical procedure and clamp success rate and results showed that majority of the patients who had successful clamp does not require further surgical procedure to undergo as compared to those without successful clamp. Blood loss was significantly less in those with successful clamp as compared to without successful clamp.
Maternal near miss in a tertiary care hospital: A retrospective and prospective observational study
Authors: Chonla Ankita , Gupta Sangeeta 
Published: August 2023

: Maternal mortality is an indicator of the quality of maternal health services provided in the country. Despite the therapeutic advances in obstetric care and growing perception of the safety of childbirth over the past few decades, maternal morbidity and mortality remain to be a challenge in developing countries like ours where little attention has been given to the near miss obstetric events. : To study the prevalence and clinical profile of Maternal near miss in a tertiary care center.: To evaluate the underlying disorders, contributory factors and socio-demographic variables among maternal near miss cases.: This observational study was undertaken at the Department of Obstetrics and Gynecology, Maulana Azad Medical College (MAMC) & associated Lok Nayak Hospital (LNH), New Delhi for a period of one year. The study population was the patients attending OPD or casualty or admitted in the Department of Obstetrics and Gynecology at LNH, MAMC, who fulfilled the MoHFW maternal near miss identifying criteria and whose case records were available. The data for the study was collected both retrospectively and prospectively from January 2019 to December 2021. Detailed history of patients like name, age, date of admission and presenting complaints were recorded. Obstetric history including history of previous pregnancy and labor, complications during present pregnancy, past and present medical problems were also recorded. For each case of MNM, the primary obstetric complication leading to near miss was evaluated.: There were 7064 live births during the study period. The study reveals a near miss ratio of 3.25 per 1000 live births. The near miss to mortality ratio was found to be 0.38:1 and the mortality index was 71.95%. Hemorrhage followed by hypertensive disorders of pregnancy were the most common disorders seen in near miss cases. All near miss cases required either HDU and/or ICU stay. The total requirement of blood and blood products by all near miss cases in the study was six whole blood, 61 packed red blood cells, 62 platelets and 42 fresh frozen plasma. The neonatal and perinatal mortality rate of our study was 38.8%.: A near-miss tool that is more generalizable, especially in a low-resource setting where many deliveries occur at home, needs to be developed. It should also be simple enough to be used by accredited social health workers, auxiliary nurse and midwife and other health care workers.
Role of anti mullerian hormone (AMH) in diagnosis of polycystic ovarian syndrome (PCOS) in Indian women
Authors: Gupta Neha , Pandey Uma , Jain Shivi , Singh Surya Kumar 
Published: August 2023

: Transvaginal ultrasound is an important part of the Rotterdam criteria, which are commonly used to diagnose polycystic ovary syndrome (PCOS). Specifically, the presence of polycystic ovarian morphology (PCOM) is a key factor in the criteria. Another useful indicator of PCOM is the Anti-Mullerian hormone (AMH) level.The objective is to evaluate the diagnostic accuracy of serum Anti-Mullerian hormone (AMH) in identifying polycystic ovary syndrome (PCOS) and determine whether it can be used as a substitute for polycystic ovarian morphology (PCOM) in the Rotterdam criteria. Additionally, we aim to investigate the relationship between AMH levels and hyperandrogenism in PCOS patients.A study was out in SSH BHU various parameters will be used in diagnosis. Serum AMH Radiology: By Transvaginal Sonography single observer obtained dimensions for ovarian volume and the maximum number of follicles in one section. AMH levels will be estimated using commercially available Gen-II ELISA assay. Biochemical evaluation will be done in the Department of Bio-Chemistry IMS BHU. The Anti-Mullerian hormone (AMH) serum levels will be measured using a commercially available ultra-sensitive Gen-II enzyme-linked immunosorbent assay (ELISA) kit from Beckman Coulter, CA. The ELISA has a lower limit of detectability (LoD) of 0.08 ng/ml, a lower limit of quantification (LoQ) of 0.17 mg/ml, and an intra-assay coefficient of variation of 5.8%. The unit of measurement is ng/mL (1ng/mL=7.14 pmol/L). The study showed that Anti-Mullerian hormone (AMH) levels were markedly higher in individuals with polycystic ovary syndrome (PCOS) than in controls. While AMH alone was not a reliable diagnostic marker for PCOS, the findings suggested that incorporating AMH levels as an additional factor in the existing Rotterdam criteria could improve the accuracy of PCOS diagnosis. Therefore, AMH levels have the potential as a useful adjunct marker for the diagnosis of PCOS.
Clinical profile of patients of turner syndrome (TS) with karyotype-phenotype corelation from a tertiary care hospital in Eastern Uttar Pradesh (UP), India
Authors: Ranjan Asha , Agrawal Neeraj Kumar , Singh Surya Kumar , Arora Saurabh , Shanthaiah Dhananjya Melkunte , Jain Rujul , Bharmal Vahid 
Published: August 2023

The present study was done to study the clinical profile and karyotype-phenotype corelation of turner syndrome patients in eastern UP, India. The present study was a retrospective observational study conducted from January 2018 to December 2020 on newly diagnosed TS patients. All patients were screened for thyroid dysfunction, celiac disease, diabetes mellitus (DM), dyslipidaemia, liver dysfunction, hearing loss, cardiovascular anomalies and renal anomalies. Data was tabulated in Microsoft excel sheet and averages and means were calculated. Fischer exact test was used to assess the corelation of karyotype with clinical phenotypic features. Total 16 patients were diagnosed with TS and 37.5% were classic 45 XO, 18.5% were mosaic 45X/46XX and rest 43.75% were of rarer TS variants. One patient had mosaicism for X chromosome with reciprocal autosomal translocation- 45X, t(12,20)(q24.1p13), 46X, t(12,20)(q24.1p13) *marker karyotype which is the first case reported so far. The average age of presentations was 16.8years ± 3.4years (range 8 to 23 years). One patient with karyotype 46,X, del(Xq22-28) had DM with negative anti-GAD antibodies and one patient with karyotype 46XX/46,X+marker had systemic lupus erythematosus (SLE). No significant karyotype and phenotype corelation was found in our study. We report rare association of SLE with TS and a novel karyotype in TS involving mosaicism for X with autosomal translocation t(12,20). No significant karyotype-phenotype corelation was found in our study. More focused studies are needed to study the genes responsible for various manifestations in TS, pathogenic mechanisms of DM and SLE in TS and the effect of autosomal translocations in TS phenotype.