bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacoeconomic analysis of tixagevimab and cilgavimab combination for COVID-19 therapy
Authors: Zhuravleva M. V. , Chulanov V. P. , Gagarina Yu. V. , Shabalina E. A. 
Published: July 2023

Objective: to evaluate the pharmacoeconomic feasibility of using monoclonal antibodies or their combinations vs standard therapy in patients with mild and moderate-severe COVID-19 in order to prevent the severe course of the disease.Material and methods. The decision tree and Markov models for calculation of costs and outcomes were used for patients with COVID-19 and post-COVID-19 syndrome, respectively. The cost-effectiveness of tixagevimab and cilgavimab was evaluated in persons ≥18 years old not vaccinated against COVID-19 with a high risk of progression to severe COVID-19. Effectiveness and safety of tixagevimab and cilgavimab combination was assessed based on TACKLE phase III study results. The quantities of life years gained (LYG) and quality-adjusted life years (QALY) were calculated. Results were compared with the wiliness-to-pay threshold measured as tripled gross domestic product per capita according the World Health Organization recommendations.Results. Treatment of COVID-19 with tixagevimab and cilgavimab results in additional 0.2657 LIGs or 0.2255 QALYs. The cost of 1 LIG was 213,4 thousand rubles, the cost of 1 QALY was 251,5 thousand rubles. Both costs of LIG and QALY appeared to be significantly less compared to the wiliness-to-pay threshold equal to 3.09 million rubles in 2022.Conclusion. Treatment of mild and moderate-severe COVID-19 is economically feasible and may be recommended for wide use in the Russian healthcare system.
ETAPA INTERMEDIÁRIA COM OS YUDJÁ DO BAIXO XINGU NO CORAÇÃO DA AMAZÔNIA
Authors: Ferreira Waldinéia Antunes de Alcântara , Cruz Mônica Cidele da 
Published: July 2023

Este artigo aborda uma experiência de prática pedagógica em pesquisa, junto ao povo Yudjá, na Terra Indígena do baixo Xingu. Tem como objetivo trazer diálogos, de pesquisa, atividades e práticas pedagógicas desenvolvidas neste contexto vivenciado em etapa intermediária do curso de Pedagogia Intercultural, da Faculdade Indígena Intercultural da Universidade do Estado de Mato Grosso. A metodologia do trabalho se insere dentro da premissa da abordagem etnográfica e participante, com observação do contexto vivenciado e com inferências na prática pedagógica em desenvolvimento. A vivência em etapa intermediária na TI Xingu, na aldeia Paksamba do povo Yudjá, apontou a complexidade das mediações do mundo vivido com o mundo acadêmico. Professores, comunidade e acadêmicos foram envolvidos pelo complexo amazônico de relações em histórias e experiências vividas no período mais crítico da Covid 19, conhecimento das águas e partilha de saberes, muito mais dos Yudjá do que da academia. Nesse contexto, os professores da universidade assumiram o lugar da escuta sensível para aprender e apreender novas significações do mundo Yudjá.
On the Development of Metrological Support for the Identification and Quantitative Determination of the Content of Non-infectious Food Allergens of Animal or Plant Protein Origin in Food Products
Authors: Pervukhina O. E. , Sergeeva A. S. , Krasheninina M. P. , Studenok V. V. , Mashkov E. S. , Petukhov P. A. , Maigurova V. N. 
Published: July 2023

In accordance with TR CU022/2011 «Food products in terms of their labeling», the content of allergens in food products is subject to mandatory control. Work on the creation of a metrological support complex for the identification and quantitative determination of the content of non-infectious food allergens of animal or plant protein origin in food products includes the development and certification of methods for identification and quantitative determination; conducting interlaboratory comparisons; creation and testing for type approval of reference materials.Within the framework of this research, work was carried out on the development and certification of methods for identifying and quantifying the content of non-infectious food allergens of plant (gluten, peanuts, nuts, soybeans) and animal (cow’s milk, chicken eggs, fish and seafood) protein origin in samples of all kinds of food products and objects related to the requirements for food products, swabs taken from work surfaces during production control using reagent kits for enzyme-linked immunosorbent assay produced by XEMA LLC.Certification of quantitative analysis methods in accordance with legal requirements in the field of ensuring the uniformity of measurements was conducted using imported reference materials of food allergens. The lowest sensitivity limits (detection limits) of the presence or absence of antigens by allergen protein weight ranged from 0.001 ppb to 5 ppm. The developed methods make it possible to ensure the safety of food products when establishing the conformity of products with the requirements of the legislation on technical regulation.
Metrological Support in the Field for the Development of Reference Materials of Isothermal Titration Calorimetry: Prospects
Authors: Mishina K. A. 
Published: July 2023

Isothermal titration calorimetry (ITC) allows studying the thermal effects of various chemical and physicochemical processes, including dissolution processes. This method is relatively new. Therefore, the active expansion of the scope of its application has revealed a number of problems. For instance, the article raises the problem of insufficient metrological support for isothermal titration calorimeters, which leads to inconsistency of the results obtained on different models of calorimeters, as well as their inconsistency with literature data. The current electrical and chemical calibration procedures for calorimeters are not universal and have a number of limitations in their application.The purpose of the research is to develop basic approaches to the creation of certified reference materials with a certified value of heat of physicochemical interactions with established metrological traceability to the base SI units.In the course of the study, the analysis of the state of metrological support in the field of ITC measurements was carried out, the main requirements for candidate substances to RMs were formulated; the target uncertainty of the value of the integral heat of dilution of propanol-1 solutions was estimated by analyzing the characteristics of working measuring instruments, which made it possible to establish requirements for the measurement method applied to characterize RMs. A method for determining the certified value of the integral heat of dilution that provides traceability to the State primary special standard of the unit of heat in the field of dissolution calorimetry and reactions GET 133 has been proposed and tested.In order to implement the project, it is necessary to continue research in order to obtain experimental data on the characterization, assessment of the homogeneity and stability of the material, processing the obtained results, and estimating the uncertainty of the certified value, which will make it possible to complete the development of reference materials.
Features of the Use of Reference Materialsimitators for Metrological Support of Gas Analytical Measuring Instruments
Authors: Kolobova A. V. , Konopelko L. A. , Sokolov T. B. , Fatina O. V. 
Published: July 2023

Gas analytical measurements are one of the types of measurements of the physical and chemical composition and properties of substances, and cover a large amount of measurement tasks in various areas of human activity. The main means of calibration of gas analytical measuring instruments are working standards of the 1stand 2ndcategory: reference materials for the composition of gas mixtures in pressure cylinders, measures – sources of microflows of gases and vapors, gas mixture generators.The purpose of the research was to summarize the many years of experience of the specialists of the Research Department of State Standards in the field of Physical and Chemical Measurements, D. I. Mendeleyev Institute for Metrology, in terms of the use of reference materials-imitators for metrological support of gas analytical measuring instruments, identification and analysis of the main factors that allow the use of imitators in testing and calibration of measuring instruments.The research considered the main features of the use of reference materials for the composition of gas mixtures in pressure cylinders as imitators of real environments in the metrological support of gas analytical measuring instruments. The main differences between imitators in terms of their equivalence with a real environment were described. Approaches have been developed to assess the possibility of using imitators, the features of testing for the purpose of type approval and verification of measuring instruments using imitators.The practical significance of the research is the possibility of using the research results by metrologists in solving practical problems that arise during tests for the purpose of type approval, and calibration of gas analytical measuring instruments.
Estimating concentration of toxic ions Arsenic in water by using Photonic Crystal Fiber based on Surface Plasmon Resonance (SPR)
Authors: Jassam Ghufran Mohammed , Ahmed Soudad S. 
Published: July 2023

في هذا العمل ، تم تصميم وتنفيذ ألياف بلورية ضوئية محسنة (PCF) تعتمد على مستشعر رنين البلازمون السطحي (SPR) باستخدام بنية مصقولة من جانب للكشف عن أيونات الزرنيخ السامة في الماء. يمكن الحصول على منحنى SPR عن طريق تلميع جانب PCF بعد طلاء غشاءAu على جانب المنطقة المصقولة، ويمكن الحصول على منحنى SPR.. المستشعر المقترح له تأثير SPR واضح، وفقًا لنتائج التجارب. تقترب نسبة الإشارة إلى الضوضاء (SNR) والتحسسية (S) و القدرة التحليلية (R) و عامل الجدارة (FOM) ؛ SNR هو 0.0125 ، S هو 11.11 μm / RIU ، القدرة التحليلية 1.8x ، و FOM هو 13.88 للألياف أحادية الوضع- الألياف البلورية الضوئية- الألياف أحادية الوضع (SMF-PCF-SMF ). في حين أن معلمات الأداء الفعالة للألياف متعددة الأوضاع - الألياف البلورية الضوئية - الألياف متعددة الأوضاع (MMF-PCF-MMF) مثل التحسسية تقترب من 9.5 ميكرومتر μm / RIU ، ، فإن SNR هي 0.0173 ، FOM هي 10.86 و القدرة التحليلية 4x تم تحقبقه. تم حساب التراكيز عمليا ونظريا لكل من المتحسسين ووجد ان التراكيز العمليةالتي تم الحصول عليها قريبة او متساوية للتراكيز التي تم الحصول عليها نظريا عن طريق قانون التخفيف حيث تم الحصول على التراكيز 0.096 و0.15 و0.26و0.38و0.49 عمليا و0.1و0.2و0.3و0.4و0.5 نظريا للSMF-PCF-SMS وتم الحصول على التراكيز 0.089و0.16و0.23و 0.34و0.45 عمليا و0.1و0.2و0.3و0.4و0.5 نظريا للMMF-PCF-MMFيحتوي المستشعر المقترح على هيكل ميكانيكي قوي ، وتكلفة منخفضة ، وسهولة تصنيع ، مما يسمح له بتوفير نطاق قياس أكبر ومنطقة عمل للعينات المقاسة دون إطالة المتحسس.
RETRACTED: Additive manufacturing of an ultrastrong, deformable Al alloy with nanoscale intermetallics
Authors: Zhang Xinghang , Shang Anyu , Stegman Benjamin , Choy Kenyi , Niu Tongjun , Shen Chao , Shang Zhongxia , Sheng Xuanyu , Lopez Jack , Hoppenrath Luke , Zhang Bohua , Wang Haiyan , Bellon Pascal 
Published: July 2023

Abstract

The authors have requested that this preprint be removed from Research Square.
More than three-fold increase of extreme dryness across Europe by end of 21st century
Authors: Shekhar Ankit , Humphrey Vincent , Buchmann Nina , Gharun Mana 
Published: July 2023

Abstract
Increases in air temperature leads to increased dryness of the air and potentially develops increased dryness in the soil. Extreme dryness (in the soil and/or in the atmosphere) affects the capacity of ecosystems for functioning and for modulating the climate for example through CO2 uptake or evaporative cooling. Here, we used daily soil moisture and vapor pressure deficit data of high spatial resolution (~ 0.1° × 0.1°) from 1950–2100 to show that compared to the reference period (1950–1990), the frequency and intensity of extreme soil dryness, extreme air dryness, and compound extreme dryness (i.e., co-occurrence of extreme soil and air dryness) has increased over last 31 years (1991–2021) and will further continue to increase in the future until 2100 across Europe. This increased intensity and frequency was most pronounced over broadleaved forests, croplands, and grasslands. Such future climate-change induced increase in extreme dry conditions could alter ecosystem functioning across Europe.
Archived cytogenetic cell pellets used to detect a BCR::ABL1 driver mutation eight years before disease presentation: a case report
Authors: Sasi Ramakrishnan , Spruill Michelle , Perrotta Peter L. 
Published: July 2023

Abstract
Background:
Evidence suggests that the earliest genetic events in the evolution of a cancer can predate diagnosis by several years or decades. In chronic myeloid leukemia (CML), the BCR::ABL1 fusion driver mutation can be present for an extended period before clinical disease manifests. The time between the BCR::ABL1 occurrence and symptom onset is referred to as the latency period. Though modeling studies predict this latency period is no more than ten years, it is still unclear how long it can be.
Case presentation:
A 57-year-old female patient with anemia, fatigue, weight loss and night sweating was referred for suspected CML. Both karyotype and FISH analysis identified the t(9;22)(q34;q11.2) translocation resulting in the Philadelphia chromosome formation. The patient responded to imatinib and achieved a sustained complete hematologic and cytogenetic remission.
Clinical history revealed that this patient was evaluated eight years previous for mild anemia and cytopenia with suspicion of myelodysplastic syndrome (MDS). There was macrocytic anemia and mild polychromasia on the peripheral blood smear which was remarkable for mild leukocytosis without a left-shift or circulating blasts. The bone marrow was normocellular without significant dysplasia and no evidence of a myeloid neoplasm. Cytogenetic analysis at that time revealed del(20q) as the sole abnormality. The patient’s condition resolved, and no treatment was provided because isolated del(20q) is not considered evidence of MDS in the absence diagnostic morphologic findings. Cytogenetic fluorescent in situ hybridization analysis of the eight-year-old archived bone marrow pellets revealed the presence of BCR::ABL1 fusion in 1.8% of cells.
Conclusion:
A clonal population of cells harboring the BCR::ABL1 fusion was unambiguously detected in this patient’s archived bone marrow pellet obtained eight years before the current CML diagnosis. This case demonstrates that Carnoy’s fixed nuclear pellets stored in cytogenetic laboratories are suitable for detecting driver mutations years before disease presentation. Such archived material may be useful for the retrospective studies needed to better understand the initiation and subsequent development of hematological malignancies. By identifying individuals who are at increased risk, it may be possible to initiate preventive measures or begin treatment at an earlier stage before disease progression
Prevalence and factors associated with thyroid dysfunction in major depressive disorder patients with dyslipidemia
Authors: Zhan Luyu , Gao Yujun , Zeng Kuan , Li Yi , Ma Jun 
Published: July 2023

AbstractBackground Major depressive disorder (MDD) is a common psychiatric disorder with a high prevalence of comorbidity with thyroid dysfunction. The aim of this study was to investigate the prevalence and factors influencing the comorbidity of thyroid dysfunction in patients with dyslipidemic MDD who were hospitalized for the first time in a Chinese population. Methods The study incorporated 708 first-time hospitalized MDD patients, all with dyslipidemia. Data collection encompassed socio-demographic information, blood pressure, fasting blood glucose (FBG), lipid, and thyroid hormone levels. Participants were evaluated using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive Symptom Subscale (PSS). Results The prevalence of thyroid dysfunction in dyslipidemic MDD patients with the first hospitalization was 39.97%. The course of the disease, age at onset, HAMA score, and low-density lipoprotein cholesterol (LDL-C) were risk factors for thyroid dysfunction in dyslipidemic MDD patients. The course of disease, age at onset, HAMA score, HAMD score, FBG, and systolic blood pressure (SBP) levels were observed to significantly influence serum Thyroid Stimulating Hormone (TSH) levels. Conclusions MDD patients with dyslipidemia have a high prevalence of thyroid dysfunction, and the outcome is associated with anxiety, fasting glucose, and lipids. This study provides direction for the prevention and treatment of thyroid dysfunction in patients with dyslipidemic MDD.
Water sources, consumption, and water-related sanitation on Pari Island, Indonesia: a mixed-focus group discussion and survey study
Authors: Wulan Diana Rahayuning , Sintawardani Neni , Marganingrum Dyah , Triyono Triyono , Bararah Barid Vera , Santoso Heru , Yulianto Eko 
Published: July 2023

Abstract
Pari Island has 1,441 inhabitants who are facing major environmental challenges related to water consumption and availability. These challenges may impact water quality and availability in the future. Previous research examining water usage and sanitation behavior on Pari Island remains limited. Since domestic activities dominate in Pari Island, this study evaluated water sources for domestic usage, estimated water consumption, and evaluated sanitation behavior, as well as community behavior and awareness. This study was based on a field survey using a questionnaire involving 317 heads of household, and had focus group discussions. The results revealed that reverse osmosis (RO) water and branded bottled water were the dominant water sources for drinking and food preparation, and RO water had become an important alternative water source for its affordable price. An individual's well water was mostly used for bathing and toilets. Annual water consumption on Pari Island for drinking, food preparation, and water-related sanitation is 24,930.74–29,401.44 m3/year, which still fell within the estimated water capacity of 290,000.48 m3/year, yet problems related to sanitation need special attention with respect to the increasing population. The awareness of the Pari Island community on technological interventions should be an advantage to maintain water sustainability.
Novel Synthetic Indazoles Abrogate Angiogenesis in Erlich Ascites Tumor Bearing
Mice
Authors: Ashwini Nanjundaswamy , Balaji Kyathegowdanadoddi S. , Sadashivaiah Bettadahalli L. , Swaroop Toreshettahally R. , Jayarama Shankar , Mantelingu Kempegowda , Rangappa Kanchugarakoppal S. 
Published: July 2023

Background:
Indazoles are known for their anti-cancer properties.

Objective:
The current investigation was on the synthesis and evaluation of novel indazole derivatives for their anticancer
properties.

Methods:
A series of novel indazoles were synthesized and characterized by IR, NMR and LCMS. We performed cytotoxic
studies for all synthesized compounds on different cell lines such as HeLa, MCF-7 and EAC using MTT assay.
The lead compound was tested further for its anti-tumor and anti-angiogenic effect on EAT tumor model.

Results:
Amongst the series of compounds synthesized, compound KA8 showed potent antiproliferative effect against
Hela, MCF-7 and EAC cell lines with IC50 values 10.4 to 11.5 and 13.5μM respectively. In addition, our compound
KA8 significantly decreased the cell viability, body weight, ascites volume and it also showed superior survival ability
of mice compared to control groups. Furthermore, it suppressed the formation of neovasculature in the peritoneum of
EAT-bearing mice.

Conclusion:
The findings reveal that the lead compound KA8 possesses potent anti-tumor and anti-angiogenic properties
thereby promising it to be developed as a novel anticancer agent with further mechanistic studies.
Social Media Interventions for Nutrition Education Among Adolescents: Scoping Review
Authors: Kulandaivelu Yalinie , Hamilton Jill , Banerjee Ananya , Gruzd Anatoliy , Patel Barkha , Stinson Jennifer 
Published: July 2023

Background
Adolescence is a critical period for reinforcing healthy dietary behaviors and supporting the development of cooking skills. Social media may be an avenue for supporting these behaviors, as it is popular among adolescents and can improve access to nutrition education interventions. This study sought to understand the optimal implementation of effective social media–based nutrition education interventions to inform the implementation of future social media–based nutrition education interventions.

Objective
A scoping review of the characteristics, feasibility, effectiveness, and factors influencing social media–based nutrition education interventions for adolescents was conducted.

Methods
We searched MEDLINE, Embase, CINAHL, Web of Science, and PsycINFO databases using a predefined search strategy. Primary research articles were independently screened and included if they involved adolescent populations (10-18 years old) and delivered nutrition education through social media. The information on intervention characteristics, feasibility, effectiveness, and factors influencing social media–based nutrition education interventions was extracted.

Results
A total of 28 publications out of 20,557 met the eligibility criteria. Twenty-five nutrition interventions were examined by 28 studies. Fourteen interventions used homegrown social media platforms, 8 used Facebook, and 2 used Instagram. Feasibility outcomes were infrequently reported, and the cost of intervention delivery was not reported. Engagement with interventions was variable; high engagement was not required to elicit significant improvements in dietary behaviors. Tailoring interventions, offering practical content, meaningful peer support, and involving families and communities facilitated successful interventions. Strategies to address engagement and technical issues were varied.

Conclusions
Emerging evidence demonstrates that social media interventions for adolescent nutrition are acceptable and improve nutrition outcomes. Future interventions should strengthen peer support components and tailor delivery to specific populations. Further research should examine engagement, adherence, and the impact of interventions on behavioral and physical outcomes. This review is the first to examine the use of social media as the primary medium for nutrition education for adolescent populations. The analysis used in this review argues the importance of peer support in social media–based nutrition interventions and the need for user-centered design of the interventions.