bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Full Multi-wake Vortex Lattice Method: a detached flow model based on Potential Flow Theory
Authors: Pimentel-Garcia Jesus Carlos 
Published: August 2023

AbstractOne of the main issues concerning the standard Vortex Lattice Method is its application to partially or fully detached flow conditions, where non-linear aerodynamic characteristics appear as the angle of attack increases and/or the aspect ratio decreases. In order to solve such limitations, a pure numerical approach based entirely on the Vortex Lattice Method concepts has been developed. The so-called steady “Full Multi-wake Vortex Lattice Method” comes from the main hypothesis that each discretized element on the body’s surface detaches their own wakes downstream. The obtained results match for lift, drag and moment coefficients for the entire aspect ratio range configurations (under straight wakes and inviscid assumptions). Future unsteady versions of such a multi-wake approach could improve the current results obtained through Vortex Element Methods (as vortons or isolated vortex filaments).
Sclerosing pneumocytoma originated in the middle mediastinum: a case report
Authors: Yoshida Chihiro , Kakizaki Mototsune , Soo Chang Sung , Okamoto Taku 
Published: August 2023

Abstract
Background
Sclerosing pneumocytoma is a benign tumor that occurs mostly in the lungs and very rarely in the middle mediastinum. It may be difficult to diagnose, as its radiological features and histologic heterogeneity mimic malignancy; therefore a histopathologic examination is required to establish a definitive diagnosis.

Case presentation
The patient was a 52-year-old woman who was found to have a tumor in the middle mediastinum on a chest CT scan and was referred to our hospital for resection. We performed a resection of the mediastinal tumor, assuming it was thymoma or teratoma, via video-assisted thoracic surgery. Histopathological analysis of the mediastinal tumor revealed it to be a sclerosing pneumocytoma.

Conclusions
Herein, we presented a case of a very rare sclerosing pneumocytoma originating from the middle mediastinum where video-assisted thoracic surgery allowed for minimally invasive resection and histopathological diagnosis of the tumor. Such procedures should be considered as the histopathological diagnosis of the tumor may help determine the optimal treatment options.
Bowlby's five therapeutic tasks: bringing them up to date for children
Authors: Wilkinson Simon R. 
Published: August 2023

SummaryBowlby remained attached to his psychoanalytic roots and conceptualised treatment in terms of one-to-one relationships, albeit acknowledging the need for a family formulation. Bowlby's five therapeutic tasks were never adapted to the current understanding of working with the relationships fostering the development and maintenance of children's attachment strategies. This paper goes through each of Bowlby's five tasks and adapts them to our current understanding of development, with consequences for prioritising family approaches, rather than a secure base alone with a therapist. In doing so I will review the process of achieving security, seeing it as more similar to an allostatic process than a state of homeostasis.
Open quantum behaviour manifested in the double-slit experiment
Authors: Marinho L. S. , de Sá Neto O. P. , Sampaio Marcos , Costa Helder A. S. , da Paz I. G. 
Published: August 2023

Abstract
In certain analyses of quantum systems, it is common to disregard the dissipation effect and focus solely on decoherence. This is because decoherence typically occurs on a much shorter timescale compared to dissipation. However, in order to gain insight into the role of dissipation, we examine the interference pattern in a double-slit experiment while considering both effects. To do so, we establish time scales for decoherence and dissipation and acknowledge the possibility of these effects occurring in close proximity. By comparing the relative intensity and fringe visibility between a purely decoherent model and a model that incorporates both decoherence and dissipation, we observe that when the time scales of decoherence and dissipation are similar, there exists a propagation time interval where dissipation contributes to a faster degradation of quantum features compared to the sole influence of decoherence. Hence, it is crucial to consider both decoherence and dissipation effects, especially when their time scales are closely aligned, to gain a comprehensive understanding of quantum behavior.
Cultural heterogeneity constrains diffusion of innovations
Authors: Pineda Aruane M. , Reia Sandro M. , Connaughton Colm , Fontanari José F. , Rodrigues Francisco A. 
Published: August 2023

Abstract
Rogers' diffusion of innovations theory asserts that the cultural similarity among individuals plays a crucial role on the acceptance of an innovation in a community. However, most studies on the diffusion of innovations have relied on epidemic-like models where the individuals have no preference on whom they interact with. Here, we use an agent-based model to study the diffusion of innovations in a community of synthetic heterogeneous agents whose interaction preferences depend on their cultural similarity. The community heterogeneity and the agents' interaction preferences are described by Axelrod's model, whereas the diffusion of innovations is described by a variant of the Daley and Kendall model of rumour propagation. The interplay between the social dynamics and the spreading of the innovation is controlled by the parameter

, which yields the probability that the agent engages in social interaction or attempts to spread the innovation. Our findings support Roger's empirical observations that cultural heterogeneity curbs the diffusion of innovations.
Enfortumab Vedotin-induced Hyperglycemia and Ileal Conduit Reconstruction-induced Metabolic Acidosis
Authors: Sato Takaaki , Suzuki Hiroshi , Asashima Yuya , Sone Hirohito 
Published: August 2023

Abstract
We report a 76-year-old man who was treated for hyperglycemia and metabolic acidosis after chemotherapy with enfortumab vedotin and pembrolizumab administered after his surgery for bladder cancer. He had an approximately 20-year history of diabetes. His body mass index was 18.6, and he received metformin 1000 mg/day, sitagliptin 50 mg/day, mitiglinide 30 mg/day, and voglibose 0.6 mg/day with hemoglobin A1c was approximately 7%. He underwent total cystectomy and ileal conduit reconstruction. After relapse, he received chemotherapy but later developed hyperglycemia and metabolic acidosis. His hyperglycemia was caused by enfortumab vedotin, and metabolic acidosis was attributable to the ileocecal canal. These symptoms should be remembered as important complications of this standard treatment, which prompted this case report.
On the Development of Peripatus Novæ-Zealandiæ
Authors: Sheldon Lilian 
Published: August 2023

ABSTRACT
The account to be given in this paper is unfortunately by no means a complete one, owing to the difficulties attendant on working at the subject in this country. The great drawback is the difficulty of obtaining the creatures, and as, so far as I know, there is no way of keeping them alive in England, it is necessary to kill them and remove the embryos as soon as they arrive, so that one is by no means certain of obtaining the stages which are required, when one does have the good fortune to obtain a supply of the creatures.
Cost-Effectiveness of [99mTc]Tilmanocept Relative to [99mTc]Sulfur Colloid for Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer
Authors: Choi Karen Y. , Hao Qiang , Carlisle Kathryn , Hollenbeak Christopher S. , Lai Stephen Y. 
Published: August 2023

Abstract
Background
Several studies have demonstrated varying rates of efficacy, reliability, and sensitivity of sentinel lymph node biopsy (SLNB) in identifying occult nodal disease for early stage oral cavity squamous cell carcinoma (OCSCC) depending on the radionuclide agent utilized. No head-to-head comparison of cost or clinical outcomes of SLNB when utilizing [99mTc]tilmanocept versus [99mTc]sulfur colloid has been performed. The goal of this study was to develop a decision model to compare the cost-effectiveness of [99mTc]tilmanocept versus [99mTc]sulfur colloid in early stage OCSCC.

Patients and Methods
A decision model of disease and treatment as a function of SLNB was created. Patients with a negative SLNB entered a Markov model of the natural history of OCSCC parameterized with published data to simulate five states of health and iterated over a 30-year time horizon. Treatment costs and quality-adjusted life-years (QALYs) for each health state were included. The incremental cost-effectiveness ratio (ICER) was then estimated using $100,000 per additional QALY as the threshold for determining cost-effectiveness.

Results
The base case cost-effectiveness analysis suggested [99mTc]tilmanocept was more effective than [99mTc]sulfur colloid by 0.12 QALYs (7.06 versus 6.94 QALYs). [99mTc]Tilmanocept was more costly, with a lifetime cost of $84,961 in comparison with $84,264 for sulfur colloid, however, the overall base case ICER was $5859 per additional QALY, well under the threshold for cost-effectiveness. Multiple one-way sensitivity analyses were performed, and demonstrated the model was robust to alternative parameter values.

Conclusion
Our analysis showed that while [99mTc]tilmanocept is more costly upfront, these costs are worth the additional QALYs gained by the use of [99mTc]tilmanocept.
Catalytic Ammonia Oxidation Using Ammonia Solution under Electrochemical Conditions: Investigation on Axial Ligand of Ruthenium Catalysts
Authors: Toda Hiroki , Kuroki Kaito , Kanega Ryoichi , Yano Tasuku , Yoshikawa Takeshi , Kuriyama Shogo , Himeda Yuichiro , Sakata Ken , Nishibayashi Yoshiaki 
Published: August 2023

Abstract
We have investigated catalytic ammonia oxidation using ruthenium complexes as catalysts under electrochemical conditions. Cyclic voltammetry and bulk electrolysis with an ammonia solution in MeCN are conducted in the presence of a catalytic amount of ruthenium complexes bearing a 2,2′-bipyridine-6,6′-dicarboxylate ligand with various 6-substituted isoquinolines and phthalazine as axial ligands. As a result, the ruthenium complex bearing phthalazines shows the highest catalytic activity at low applied potentials, where up to 319 equivalents of dinitrogen per catalyst are generated.
Identification of high-performing antibodies for amyloid-beta precursor protein for use in Western Blot, immunoprecipitation and immunofluorescence
Authors: Ayoubi Riham , Fotouhi Maryam , Worrall Donovan , Southern Kathleen , Laflamme Carl ,   NeuroSGC/YCharOS/EDDU collaborative group,   ABIF consortium
Published: August 2023

The amyloid-beta precursor protein is a transmembrane protein expressed in many tissues and highly concentrated in the brain. The protein is of significant interest due to its involvement in the generation of amyloidogenic β-amyloid peptides, prone to plaque formation that is characteristic of Alzheimer’s Disease. The scientific community would benefit from the availability of high-quality anti-amyloid-beta precursor protein antibodies to enhance reproducible research on this target. In this study, we characterized eleven amyloid-beta precursor protein commercial antibodies for Western blot, immunoprecipitation, and immunofluorescence using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. We identified many high-performing antibodies and encourage readers to use this report as a guide to select the most appropriate antibody for their specific needs.
PESQUISA NA EDUCAÇÃO BÁSICA: CONTRIBUIÇÕES PARA O ENFRENTAMENTO DAS FAKE NEWS
Authors: Reis Haydéa Maria Marino de SantAnna , Benchimol Geisa Moreira Regazzi Gerk 
Published: August 2023

O avanço exponencial das Tecnologias de Informação e Comunicação (TIC) possibilitou a ampliação da coletividade de indivíduos na discussão sobre notícias jornalísticas, como também forneceu as condições para o incremento da disseminação de fake news. Nesse contexto, identificamos a ambiguidade das TIC que, tanto servem para estimular a produção de conhecimento, como apresentam desafios para ações pedagógicas na escola (BAUMAN, 1999, 2009). A partir desse cenário, a escrita deste artigo teve por objetivo analisar os conceitos de informação, conhecimento e fake News, com vistas a descrever como as práticas de leitura interdisciplinares, mediadas por docentes da Educação Básica, descritas na literatura especializada, podem favorecer o desenvolvimento do pensamento crítico, de forma a contribuir para o enfrentamento de fake news. Para isso, o estudo ancorou-se na pesquisa bibliográfica de natureza exploratória, por buscar “desenvolver, esclarecer e modificar conceitos e idéias, tendo em vista a formulação de problemas mais precisos ou hipóteses pesquisáveis para estudos posteriores”, conforme definição dada em Gil (2008, p. 46). Os procedimentos metodológicos adotados pautaram-se na seleção, organização e interpretação dos conceitos-chave, do conceito de interdisciplinaridade em Kleiman (1999) e Moita Lopes (2004; 2006) e a reflexão sobre o contexto de produção dos textos jornalísticos (Castilho e Coelho, 2014). Concluímos, que é possível estimular o desenvolvimento do pensamento crítico dos alunos, através de práticas interdisciplinares de leitura do gênero textual jornalístico (KLEIMAN, 1999), dessa forma a escola pode contribuir para o combate de fake news.
MECANISMOS DE CONSOLIDAÇÃO DA CULTURA DA IGNORÂNCIA: O COTIDIANO DE UM GRUPO ANTI-VACINA
Authors: Borges dos Santos Matheus Lincoln , Leite Alvaro Emilio , Lambach Marcelo 
Published: August 2023

Pesquisa que apresenta e discute o conceito de agnotologia, a consolidação da cultura da ignorância e sua proliferação por meio das tecnologias digitais, especialmente àquelas que, por meio da internet, possibilitam a divulgação de mensagens em massa nas redes sociais. Discute-se os mecanismos utilizados por alguns segmentos da sociedade, tais como, o político, o econômico e o religioso, para atacar e descontruir o conhecimento científico legitimado ao longo dos tempos. Como trabalho empírico, apresenta-se a análise de mensagens de um grupo de Telegram com aproximadamente 2600 integrantes em que se evidência a construção e disseminação de notícias falsas sobre vacinas e tratamento precoce contra a Covid-19. Os resultados mostram que pelas postagens do grupo circulam materiais e conteúdo nos quais utiliza-se o recurso da criação da dúvida, do conflito, de propagandas institucionalizadas, do apelo emocional e da divulgação de notícias verdadeiras imiscuídas entre as falsas para dar credibilidade à desinformação que se pretende espraiar. Por fim, reafirma-se o papel do Ensino de Ciências, bem como a importância do letramento científico e midiático para o combate da agnotologia.
Syndorm vyhoření softwarových vývojářů v agilním vývoji
Authors: Vafek Zdeněk 
Published: August 2023

Riziko syndromu vyhoření se v populaci neustále zvyšuje a postihuje mnoho softwarových vývojářů v agilním vývoji. Tento syndrom se projevuje únavou, sníženým výkonem, nedostatkem motivace, ztrátou zájmu o práci a neschopností efektivně se soustředit na úkoly. Softwaroví vývojáři pracují především v agilním vývoji, což je velmi náročný proces, který vyžaduje neustálou adaptabilitu, komunikaci a spolupráci s ostatními členy týmu. Kombinace náročnosti práce a nedostatečného odpočinku přispívá ke zvýšenému stresu, úzkosti a depresi, což může mít za následek syndrom vyhoření.
Aby se zabránilo syndromu vyhoření, je důležité, aby vývojáři měli dostatek podpory od svého týmu a nadřízených. Nezbytná je také možnost řídit si svůj čas a mít dostatek prostoru na odpočinek a regeneraci. Komunikace a spolupráce s ostatními členy týmu je také klíčová, aby se minimalizoval stres a úzkost a vývojáři měli pocit, že mají kontrolu nad svojí prací. Vývojáři by měli také svou práci pravidelně reflektovat a přemýšlet o tom, jak si mohou zlepšit své pracovní podmínky a předejít syndromu vyhoření. Pomocí využití agilního přístupu a metody Scrum lze detekovat možnost vzniku příčinných souvislostí vedoucích k syndromu vyhoření na základě dlouhodobého měření Story points. Z důvodu využití krátkých iterací v metodě Scrum je možné na faktory vedoucí k syndromu vyhoření včas upozornit a tím snížit riziko ohrožení prací na projektu.
Článek byl publikován v rámci sborníku příspěvků XV. odborné konference doktorského studia Soudního inženýrství, Junior Forensic Science (JuFoS), 18.–19. května 2023 v Brně.
Sp1 mediated the inhibitory effect of glutamate on pulmonary surfactant synthesis
Authors: Li Xiao-Hong , Fu Jie-Jun , Shi Xiao-Juan , Zhang Yun-Na , Shao Min , Yue Shao-Jie , Li Chen , Luo Zi-Qiang 
Published: August 2023

Background
Studies have shown that the release of endogenous glutamate (Glu) participates in lung injury by activating N-methyl-D-aspartate receptor (NMDAR), but the mechanism is still unclear. This study was to investigate the effects and related mechanisms of Glu on the lipid synthesis of pulmonary surfactant (PS) in isolated rat lung tissues.

Methods
The cultured lung tissues of adult SD rats were treated with Glu. The amount of [3H]-choline incorporation into phosphatidylcholine (PC) was detected. RT-PCR and Western blot were used to detect the changes of mRNA and protein expression of cytidine triphosphate: phosphocholine cytidylyltransferase alpha (CCTα), a key regulatory enzyme in PC biosynthesis. Western blot was used to detect the expression of NMDAR1, which is a functional subunit of NMDAR. Specific protein 1 (Sp1) expression plasmids were used. After transfected with Sp1 expression plasmids, the mRNA and protein levels of CCTα were detected by RT-PCR and Western blot in A549 cells. After treated with NMDA and MK-801, the mRNA and protein levels of Sp1 were detected by RT-PCR and Western blot in A549 cells.

Results
Glu decreased the incorporation of [3H]-choline into PC in a concentration- and time- dependent manner. Glu treatment significantly reduced the mRNA and protein levels of CCTα in lungs. Glu treatment up-regulated NMDAR1 protein expression, and the NMDAR blocker MK-801 could partially reverse the reduction of [3H]-choline incorporation induced by Glu (10−4 mol/L) in lungs. After transfected with Sp1 plasmid for 30 h, the mRNA and protein expression levels of CCTα were increased and the protein expression of Sp1 was also up-regulated. After A549 cells were treated with NMDA, the level of Sp1 mRNA did not change significantly, but the expression of nucleus protein in Sp1 was significantly decreased, while the expression of cytoplasmic protein was significantly increased. However, MK-801could reverse these changes.

Conclusions
Glu reduced the biosynthesis of the main lipid PC in PS and inhibited CCTα expression by activating NMDAR, which were mediated by the inhibition of the nuclear translocation of Sp1 and the promoter activity of CCTα. In conclusion, NMDAR-mediated Glu toxicity leading to impaired PS synthesis may be a potential pathogenesis of lung injury.
Implementing a physical activity project for people with dementia in Germany–Identification of barriers and facilitator using consolidated framework for implementation research (CFIR): A qualitative study
Authors: Cardona Maria Isabel , Monsees Jessica , Schmachtenberg Tim , Grünewald Anna , Thyrian Jochen René 
Published: August 2023

Background
Despite physical activity (PA) health benefits, people with dementia (PwD) continue to report low levels of PA engagement compared with healthy older adults. Evidencing that PA initiatives still not reflect effective practice and outcomes. Previous studies have shown that several factors can mediate PA initiatives implementation in this population. However, most prior research have not use implementation science frameworks to outline in-depth barriers and facilitators that enables improved PA strategies in PwD. Therefore, a more holistic understanding of mediating factors is still needed.

Objective
To identify multilevel barriers and facilitator factors, applying the Consolidated Framework for Implementation Research (CFIR) to orient a systematic evaluation of one PA project in PwD and provide evidence-based evaluation results to enhance PA implementation efforts for PwD.

Method
A qualitative study implemented in 4 German sports associations that applied a PA project for PwD. A total of 13 semi-structured interviews were conducted with 21 participants, project leaders (PLs) and sports trainers (STs). The Consolidated Framework for Implementation Research (CFIR) was used as an evaluation framework to orient both the data collection and analysis.

Results
A total of 13 interviews were conducted with 21 participants. The CFIR guided the identification of barriers and facilitating factors that need to be targeted at different levels for successful implementation. Barriers were identified, especially in the external level, as more solid networks and funding for sustainable proposals are still needed. Other barriers were low participation rates, stigma around the disease and the COVID 19 pandemic. On an individual and structural level facilitators were found like motivated appointed leaders, established planning process, and external organizations supporting sports associations in the implementation.

Conclusion
Sports projects for PwD can benefit from structuring their interventions based on the CFIR framework as it helps identify multilevel factors that may influence their success and promote PA among PwD. Future efforts should continue working on implementing frameworks that facilitate and reduce the complexity of implementing sustainable PA projects for PwD.