bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the Therapeutic Potential of Sophora flavescens Aiton in Myocardial Infarction: An Integrative Approach Combining Bioinformatics, Network Pharmacology, and Experimental Validation
Authors: Zhang Zhongbai , Tong Yang , Xie Hongwei , Jiang Mengting , Li Yanchun , Liang Chun 
Published: January 2025

Aims:
This study aims to elucidate the relationship between potential MI targets and SFA’s mechanism
of action, providing a theoretical basis for clinical development of new drugs.

Background:
Myocardial infarction (MI) has been identified as one of the major cardiovascular diseases with
adverse consequences. Sophora flavescens Aiton (SFA) is indicated for the therapeutic treatment of MI. However,
there is no systematic research on the new therapeutic targets for MI and the exact action mechanism of
SFA.

Objective:
This study explores the potential mechanisms of SFA in treating MI by integrating bioinformatics,
network pharmacology analyses and experimental verification.

Methods:
New MI targets were predicted using bioinformatics techniques. Network pharmacology and molecular
docking jointly served for predicting the key targets and underlying mechanisms of SFA. A machine
learning model was developed to identify the core MI targets. Subsequently, H9c2 cardiomyocytes hypoxia
model was established for experimental verification.

Results:
140 active components were ascertained in SFA and 59 differentially expressed genes (DEGs) were
screened for MI. Eighty-seven shared genes were obtained by WGCAN. Eighty proteins and 413 interactions
were identified by PPI network. After building the machine model, three core targets were identified (STAT1,
TNFRSF1A and MCL1). According to in vitro experiments, SFA exerts a protective effect relying on three
core targets and biological processes, including cell viability, the inflammatory response, and antiapoptotic
effects, etc.

Conclusion:
This study finds new core targets for MI and the therapeutic activity of SFA against MI, of
which the experimental verification provides valuable insights into the molecular mechanisms underlying
SFA’s efficacy in MI treatment and paves the way for targeted drug development strategies.
Lutein and Zeaxanthin: Source, Extraction, Stability, Bioactivity, and Functional Food Applications
Authors: Pandey Surabhi , Gupta Akansha , Mahato Dipendra Kumar , Paul Veena , Tripathi Abhishek Dutt , Rasane Prasad , Kumar Pradeep , kamle Madhu , Haque Shafiul 
Published: January 2025

Abstract:
Nature has been acknowledged as a fundamental source of diverse bioactive molecules.
Among natural carotenoids, lutein, zeaxanthin, and their oxidative metabolites are specifically
deposited in the macular region of living organisms. Lutein and zeaxanthin are carotenoids
primarily found in green leafy vegetables, eggs, and various fruits. Lutein and zeaxanthin
emerge as the primary carotenoids in the retina, playing a crucial role as photo-protectants
to prevent retinal degeneration. The extraction of lutein and zeaxanthin from natural sources
involves several techniques, including solvent extraction and supercritical fluid extraction,
with an emphasis on optimizing efficiency and yield. Incorporating these carotenoids into
functional foods—such as fortified dairy products, baked goods, and snacks—enhances their
nutritional profiles and provides significant health benefits. This review examines the sources,
stability, bioactivity, and various extraction methods for lutein and zeaxanthin, highlighting
their potential for photoprotection, antioxidant activity, and antidiabetic effects. These attributes,
combined with innovative extraction techniques, position lutein and zeaxanthin as promising
ingredients for functional food applications.
A Serious Game to Study Reduced Field of View in Keyhole Surgery: Development and Experimental Study
Authors: Whitley Phoebe , Creasey Connor , Clarkson Matthew J , Thompson Stephen 
Published: January 2025

Background
During keyhole surgery, the surgeon is required to perform highly demanding tasks while only being able to see part of the patient’s anatomy. This limited field of view is widely cited as a key limitation of the procedure, and many computational methods have been proposed to overcome it. However, the precise effects of a limited field of view on task performance remain unknown due to the lack of tools to study these effects effectively.

Objective
This paper describes our work on developing a serious game with 2 objectives: (1) to create an engaging game that communicates some of the challenges of keyhole surgery, and (2) to test the effect of a limited field of view on task performance. The development of a serious game that can be played by a wide range of participants will enable us to gather quantitative data on the effects of the reduced field of view on task performance. These data can inform the future development of technologies to help surgeons reduce the impact of a limited field of view on clinical outcomes for patients. The game is open source and may be adapted and used by other researchers to study related problems.

Methods
We implemented an open-source serious game in JavaScript, inspired by the surgical task of selectively cauterizing blood vessels during twin-to-twin transfusion surgery. During the game, the player is required to identify and cut the correct blood vessel under different fields of view and varying levels of vascular complexity. We conducted a quantitative analysis of task performance time under different conditions and a formative analysis of the game using participant questionnaires.

Results
We recruited 25 players to test the game and recorded their task performance time, accuracy, and qualitative metrics. Reducing the field of view resulted in participants taking significantly longer (P<.001) to perform otherwise identical tasks (mean 6.4 seconds, 95% CI 5.0-7.8 seconds vs mean 13.6 seconds, 95% CI 10.3-16.9 seconds). Participants found the game engaging and agreed that it enhanced their understanding of the limited field of view during keyhole surgery.

Conclusions
We recruited 25 players to test the game and recorded their task performance time, accuracy, and qualitative metrics. Reducing the field of view resulted in participants taking statistically significantly longer (16.4 vs 9.8 seconds; P=.05) to perform otherwise identical tasks. Participants found the game engaging and agreed that it enhanced their understanding of the limited field of view during keyhole surgery.
Swedish Version of the System Usability Scale: Translation, Adaption, and Psychometric Evaluation
Authors: Åvik Persson Helene , Castor Charlotte , Andersson Nilla , Hylén Mia 
Published: January 2025

Abstract

Background
The Swedish health care system is undergoing a transformation. eHealth technologies are increasingly being used. The System Usability Scale is a widely used tool, offering a standardized and reliable measure for assessing the usability of digital health solutions. However, despite the existence of several translations of the System Usability Scale into Swedish, none have undergone psychometric validation. This highlights the urgent need for a validated and standardized Swedish version of the System Usability Scale to ensure accurate and reliable usability evaluations.

Objective
The aim of the study was to translate and psychometrically evaluate a Swedish version of the System Usability Scale.

Methods
The study utilized a 2-phase design. The first phase translated the System Usability Scale into Swedish and the second phase tested the scale’s psychometric properties. A total of 62 participants generated a total of 82 measurements. Descriptive statistics were used to visualize participants’ characteristics. The psychometric evaluation consisted of data quality, scaling assumptions, and acceptability. Construct validity was evaluated by convergent validity, and reliability was evaluated by internal consistency.

Results
The Swedish version of the System Usability Scale demonstrated high conformity with the original version. The scale showed high internal consistency with a Cronbach α of .852 and corrected item-total correlations ranging from 0.454 to 0.731. The construct validity was supported by a significant positive correlation between the System Usability Scale and domain 5 of the eHealth Literacy Questionnaire (P=.001).

Conclusions
The Swedish version of the System Usability Scale demonstrated satisfactory psychometric properties. It can be recommended for use in a Swedish context. The positive correlation with domain 5 of the eHealth Literacy Questionnaire further supports the construct validity of the Swedish version of the System Usability Scale, affirming its suitability for evaluating digital health solutions. Additional tests of the Swedish version of the System Usability Scale, for example, in the evaluation of more complex eHealth technology, would further validate the scale.
PARTISIPASI MASYARAKAT DALAM LEGISLASI DI INDONESIA MENURUT KONSEP SYURA
Authors: Jamhuri Jamhuri , Farhani Abidah 
Published: January 2025

Pelaksanaan legislasi Indonesia melibatkan partisipasi masyarakat. Posisi dan kedudukan partisipasi masyarakat tersebut diakui di dalam Undang-Undang No. 12 Tahun 2011 Tentang Pembentukan Peraturan Perundang-Undangan (UUP3). Dalam perspektif Islam, peran serta masyarakat juga diakui dalam konsep syūrā. Untuk itu permasalahan yang dikaji ialah apa bentuk partisipasi masyarakat di dalam proses legislasi, serta bagaimana pelaksanaan partisipasi masyarakat dalam UUP3 menurut konsep syūrā? dan bagaimana pandangan syura terhadap legislasi di Indonesia? Kajian penelitian ini menggunakan pendekatan yuridis normatif ataupun statute approach. Hasil penelitian ini bahwa bentuk-bentuk partisipasi masyarakat dalam legislasi di Indonesia ialah partisipasi melalui organisasi, lembaga, instansi terkait melalui Rapat Dengan Pendapat Umum (RDPU), masukan secara lisan/tertulis di tiap tahapan pembentukan peraturan perundang-undangan atas nama individu dan kelompok dilakukan secara daring dan luring, melalui kegiatan konsultasi publik, RDPU, kunjungan kerja, loka karya, seminar, diskusi, melalui kegiatan konsultasi publik yang lainnya. Ditinjau menurut konsep syūrā, partisipasi masyarakat di Indonesia yang diatur dalam UUP3 sesuai dengan konsep syūrā, karena dalam syūrā serta dalam partisipasi masyarakat di Indonesia, keterlibatan masyarakat telah diakui dalam pengambilan keputusan melalui jalan syūrā/musyawarah. Dengan demikian legislasi di Indonesia sangat relevan dan sesuai dengan pembentukan hukum dalam pandangan Islam.
Cost-effectiveness of vaccination against HPV of adolescent girls in the regions of Russian Federation
Authors: Rudakova A. V. , Kharit S. M. , Lobzin Yu. V. 
Published: January 2025

Vaccination against human papillomavirus infection is not included in the National Calendar of Preventive Vaccinations of the Russian Federation, and vaccination is only available through regional programs. At the same time, the cost­effectiveness of vaccination in the regions of the Russian Federation may vary significantly.The aim of this study was to assess the cost­effectiveness of vaccination with the 4­valent HPV vaccine in 12­year­old girls in the regions of the Russian Federation.Materials and methods. A Markov model with a lifetime horizon for 12­year­old girls based on epidemiological data for the Russian Federation was used. The cost­effectiveness analysis was carried out from societal perspective. Costs and life expectancy were discounted at 3% per year.Results. In most regions of the Russian Federation, vaccination of girls is cost saving or highly cost­effective (the cost per additional quality­adjusted life year (QALY) does not exceed the value of gross regional product per capita). Only in Dagestan, Chechnya and Ingushetia the vaccination of girls can be considered as cost­effective, but not highly costeffective tool (incremental costs per QALY exceed the GRP per capita by 14,2­37,0%).Conclusions. Vaccination of girls before the onset of sexual activity with the 4­valent HPV vaccine is highly costeffective in most regions of the Russian Federation.
Two-Sided Matching in the Audit Market
Authors: Li Ken , McNichols Maureen , Raghunandan Aneesh 
Published: January 2025

ABSTRACT
We develop and estimate a two-sided matching model of auditors and clients. We find evidence that auditors and clients engage in matching based on their preferences on both observable and unobservable characteristics. This matching appears to partly explain the “Big 4 effect” on audit outcomes: after controlling for the effects of matching, we find that the positive influence of having a Big 4 auditor on serious restatements and serious comment letter conversations with the SEC either weakens or disappears. Collectively, our results highlight the importance of accounting for two-sided matching between auditors and clients in understanding the influence of auditors on clients’ financial reporting practices.
JEL Classifications: M40; M42
Derivation and Validation of D-RISK: An Electronic Health Record–Driven Risk Score to Detect Undiagnosed Dysglycemia in Clinical Practice
Authors: Bowen Michael E. , Lingvay Ildiko , Meneghini Luigi , Moran Brett , Santini Noel O. , Zhang Song , Halm Ethan A. 
Published: January 2025

OBJECTIVE
We derive and validate D-RISK, an electronic health record (EHR)-driven risk score to optimize and facilitate screening for undiagnosed dysglycemia (prediabetes + diabetes) in clinical practice.

RESEARCH DESIGN AND METHODS
We used retrospective EHR data (derivation sample) and a prospective diabetes screening study (validation sample) to develop D-RISK. Logistic regression with backward selection was used to predict dysglycemia (HbA1c ≥5.7%) using diabetes risk factors consistently captured in structured EHR data. Model coefficients were converted to a points-based risk score. We report discrimination, sensitivity, and specificity and compare D-RISK to the American Diabetes Association (ADA) risk test and the ADA and United States Preventive Services Task Force (USPSTF) screening guidelines.

RESULTS
The derivation cohort included 11,387 patients (mean age 48 years; 65% female; 42% Hispanic; 32% non-Hispanic Black; mean BMI 32; 29% with hypertension). D-RISK included age, race, BMI, hypertension, and random glucose. The area under curve (AUC) for the risk score was 0.75 (95% CI 0.74–0.76). In the validation screening study (n = 519), the AUC was 0.71 (95% CI 0.66–0.75) which was better than the ADA and USPSTF diabetes screening guidelines (AUC = 0.52 and AUC = 0.58, respectively; P &lt; 0.001 for both). Discrimination was similar to the ADA risk test (AUC = 0.67) using patient-reported data to supplement EHR data, although D-RISK was more sensitive (75% vs. 61%) at the recommended screening thresholds.

CONCLUSIONS
Designed for use in EHR, D-RISK performs better than commonly used screening guidelines and risk scores and may help detect undiagnosed cases of dysglycemia in clinical practice.
Efficacy and Safety of Inhaled Administration of Corticosteroids in the Frame of Controlling Chronic Coughing in Dogs with Endocardiosis and Congestive Heart Failure
Authors: Kartashov S. N. , Petrova M. A. 
Published: January 2025

Introduction. The main cause of chronic coughing in dogs with endocardiosis is the simultaneous occurrence of chronic bronchitis and airway collapse. Oral administration of topical corticosteroids quickly improves the clinical signs in animals, but after their administration is stopped, the undesirable signs resume. The authors deem it necessary to study the inhaled administration of corticosteroids, which, in contrast to oral administration, delivers the drug directly to the airways reducing the number of systemic side effects. The aim of the present research is to determine the efficacy and safety of inhaled administration of topical corticosteroids in the frame of controlling chronic coughing in dogs with endocardiosis and congestive heart failure.Materials and Methods. In total, 19 dogs of small breeds with endocardiosis, congestive heart failure (CHF) and a history of chronic coughing during more than three months were included in the research. The age of the animals ranged from 7 to 15 years, an average age was 12.3 years. All dogs underwent a complete blood count, serum biochemistry profile test, urinalysis, radiography of the neck and chest in three projections, and an echocardiography. Dogs with detected systemic diseases were excluded from the research. All dogs were prescribed fluticasone inhalations: one inhalation of 6–8 inhales 2 times a day using an AeroDawg-type inhaler spacer. Every 7 days during 35 days, the owners were completing a questionnaire on cough characteristics. Clinical examination of animals was carried out every 7 days including auscultation and ultrasound examination of the chest to detect the pulmonary edema and fluid in the chest. For early detection of CHF decompensation, the following indices were assessed by means of echocardiography: left atrium-to-aorta ratio; left ventricular internal diastolic diameter; ejection fraction of the left ventricle and left ventricular contraction.Results. Inhaled administration of fluticasone has improved the quality of life of dogs — a positive effect has been noticed in animals already from the second week of treatment, and by the 21st day the stabilization of the patients' condition has been recorded. Coughing in general, as well as individual frequency, duration and severity of cough have decreased to minimum. Also, treatment with fluticasone has proved its safety, because within 35 days neither left ventricular systolic function impairment nor lung congestion increase, nor signs of pulmonary edema have been detected.Discussion and Conclusion. The research results have proved the efficacy and safety of inhaled fluticasone in the frame of controlling coughing in dogs with endocardiosis and congestive heart failure. However, since treatment with fluticasone was evaluated only for 35 days, further studies with a longer observation period are necessary to exclude the possibility of cardiovascular complications.
Voiko ravitsemusepidemiologinen tutkimus antaa perusteet väestön ravintosuositusten laatimiselle?
Authors: Pietinen Pirjo 
Published: January 2025

Ravintosuosituksia on periaatteessa kahdenlaisia: perinteiset Recommended Daily Allowance -tyyppiset suositukset, joissa määritellään ravintoaineille vähimmäissaantitasot, joiden katsotaan riittävän takaamaan hyvän ravitsemustilan, sekä toisaalta yleisemmällä tasolla tehdyt suositukset, jotka tähtäävät kansanravitsemuksen parantamiseen.
Suositusten perustana oleva tutkimustieto kasvaa nopeasti, mutta silti yksittäisiin suosituslukuihin ei ole helppo päätyä. Esimerkkinä selvitetään suolan käyttöä koskevan suosituksen taustoja. Ravitsemusepidemiologinen tutkimus suuntautuu yhä enemmän suuriin kohorttitutkimuksiin ja interventioihin, joiden uskotaan antavan runsaasti uutta tietoa etenkin ravinnon ja syöpätautien välisten yhteyksien osalta jo tämän vuosikymmenen kuluessa.
Revisión sistemática de programas de entrenamiento cognitivo basados en IA: algoritmos, poblaciones y dominios cognitivos estimulados
Authors: Bedoya Leiva Oscar Fernando , Figueroa-Polanco Paula Andrea 
Published: January 2025

Este artículo presenta una revisión bibliográfica dividida en dos fases. La primera fase expone los hallazgos encontrados en la literatura gris sobre programas de entrenamiento cognitivo que implementan estrategias de inteligencia artificial (IA) con uso comercial. La segunda fase muestra los resultados de la búsqueda realizada en bases de datos científicas, centrándose en estudios que describen el diseño e implementación de software para entrenamientos cognitivos mediante el uso de algoritmos de IA. El objetivo ha sido identificar qué algoritmos inteligentes fueron implementados, qué funcionalidades o momentos dentro de los entrenamientos cognitivos intervienen estos algoritmos, qué poblaciones se han estudiado y qué dominios cognitivos fueron estimulados. La revisión se ha realizado siguiendo el protocolo PRISMA (por sus siglas en inglés Preferred Reporting Items for Systematic reviews and Meta-Analyzes), guiada por una pregunta de investigación que orientó tanto la búsqueda de software comercial en literatura gris como la realizada en siete bases de datos científicas. En la literatura gris se lograron identificar 31 plataformas de uso comercial para entrenamientos cognitivos que hacen uso de algoritmos inteligentes, mientras que de las revistas científicas se extrajeron 291 registros. Tanto los programas comerciales como los artículos fueron filtrados siguiendo los criterios de inclusión establecidos para obtener una selección final de cuatro programas y nueve artículos que han sido utilizados para los propósitos de este estudio en la fase de análisis. Los hallazgos mostraron que los algoritmos inteligentes más utilizados son los sistemas de recomendación, particularmente los de filtrado colaborativo, y se utilizan en mayor proporción para proponer desafíos durante las sesiones de entrenamiento o para variar la dificultad de los ejercicios a partir de los resultados que obtienen los participantes. El objetivo poblacional en las plataformas comerciales son participantes de cualquier edad, particularmente adultos de edad media, mientras que en las investigaciones los grupos etarios más estudiados se enfocaron en niños con enfermedades o trastornos de aprendizaje y adultos mayores entre los 60 y 90 años con deterioro cognitivo o lesiones cerebrales. En ambos casos, apuntan a estimular en un mayor porcentaje dominios cognitivos como la atención, la memoria y las funciones ejecutivas.
Understanding and utilising the interplay between two frameworks relating to teacher professional development: a case study
Authors: Haidi Hamizah , Winterbottom Mark 
Published: January 2025

Abstract
In England, there has been a teacher recruitment and retention crisis for many years. In such a crisis, it is important that initial teacher education (ITE) providers are able to identify, recruit and educate ‘high quality’ applicants to join the teaching profession. In this study, we focused on two case studies of beginning teachers who were enrolled in a University-School ITE Partnership. By listening to these two novice teachers, and analysing their experiences against two frameworks of professional development (the professional learning continuum of Wilson & Demetriou (2007) and the characteristics of effective teachers identified by Korthagen & Wubbels (2001)), we explain how a synthesis of the frameworks could help ITE providers to select, monitor and assess beginning teachers’ developmental trajectory when learning to teach.