bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human bocavirus respiratory infection: Tracing the path from viral replication and virus‐cell interactions to diagnostic methods
Authors: Colazo Salbetti María Belén , Boggio Gabriel Amilcar , Moreno Laura , Adamo María Pilar 
Published: September 2023

AbstractHuman bocaviruses were first described between 2005 and 2010, identified in respiratory and enteric tract samples of children. Screening studies have shown worldwide distribution. Based on phylogenetic analysis, they were classified into four genotypes (HBoV1‐4). From a clinical perspective, human bocavirus 1 (HBoV1) is considered the most relevant, since it can cause upper and lower acute respiratory tract infection, mainly in infants, including common cold, bronchiolitis, and pneumonia, as well as wheezing in susceptible patients. However, the specific processes leading to structural, biochemical, and functional changes resulting in the different clinical presentations have not been elucidated yet. This review surveys the interactions between the virus and target cells that can potentially explain disease‐causing mechanisms. It also summarises the clinical phenotype of cases, stressing the role of HBoV1 as an aetiological agent of lower acute respiratory infection in infants, together with laboratory tests for detection and diagnosis. By exploring the current knowledge on the epidemiology of HBoV1, insights into the complex scenario of paediatric respiratory infections are presented, as well as the potential effects that changes in the circulation can have on the dynamics of respiratory agents, spotlighting the benefits of comprehensively increase insights into incidence, interrelationships with co‐circulating agents and potential control of HBoV1.
Simultaneous Performance and Stability Enhancement in Intermediate Temperature Solid Oxide Fuel Cells by Powder‐Atomic Layer Deposited LSCF@ZrO2 Cathodes
Authors: Jo Sung Eun , Jeon SungHyun , Kim Hyong June , Yang Byung Chan , Ju Kyoungjae , Gür Turgut M. , Jung WooChul , An Jihwan 
Published: September 2023

AbstractEmploying porous structures is essential in high‐performance electrochemical energy devices. However, obtaining uniform functional coatings on high‐tortuosity structures can be challenging, even with specialized processes such as atomic layer deposition (ALD). Herein, a novel method for achieving a porous composite electrode for solid oxide fuel cells by coating La0.6Sr0.4Co0.2Fe0.8O3−δ (LSCF) powders with ZrO2 using a powder ALD process is presented. Unlike conventional ALD, powder ALD can be used to fabricate extremely uniform coatings on porous electrodes with a thickness of tens of micrometers. The powder ALD ZrO2 coating is found to effectively suppress chemical degradation of the LSCF electrodes. The cell with the powder ALD coated cathode shows a 2.2 times higher maximum power density and 60% lower thermal degradation in activation resistance than the bare LSCF cathode cell at 700–750 °C. The result demonstrated in this study is expected to have significant implications for high‐performance and durable electrodes in energy conversion/storage devices.
Summer upper-level jets modulate the response of South American climate to ENSO
Authors: Collazo Soledad , García-Herrera Ricardo , Barriopedro David 
Published: September 2023

AbstractThe upper-level jet stream is a critical element of atmospheric circulation, driving synoptic systems and extreme weather events. This study analyzes the impact of upper-level jets on South American (SA) summer temperature and precipitation under different El Niño-Southern Oscillation (ENSO) phases. Using the ERA5 reanalysis dataset from 1979 to 2022, we perform a daily multiparametric characterization of the jet stream, considering its spatial and temporal discontinuities. Besides latitude and intensity, we find that the departure and number of branches of the subtropical jet (STJ) and the longitudinal extent of the Pacific branch of the polar front jet (PFJ) are needed for their description. An additional parameter is required to characterize the STJ due to its absence on around 40% of summer days over SA. Moreover, we observe distinct long-term changes in PFJ parameters across different ocean basins. Three synoptic weather types (WTs) of the upper-level zonal wind are identified: normal conditions, a prominent STJ pattern, and a PFJ-only pattern. The latter pattern is associated with anticyclonic anomalies at 500 hPa in the South Atlantic Ocean and an active SA Convergence Zone, which favors clear skies and warm (wet and cold) conditions in southern SA (Brazil). Consistently, the probability of experiencing warm spells in central Argentina is increased more than twofold. Finally, we detect that the temperature anomalies associated with the WTs are independent of the ENSO phase. However, ENSO modulates the frequency of the WTs: during La Niña (El Niño), the PFJ-only (prominent STJ) pattern is more common.
Unveiling the role of cerebellar alterations in the autonomic nervous system: a systematic review of autonomic dysfunction in spinocerebellar ataxias
Authors: Urbini Nicole , Siciliano Libera , Olivito Giusy , Leggio Maria 
Published: September 2023

Abstract
Background
Autonomic dysfunctions are prevalent in several cerebellar disorders, but they have not been systematically investigated in spinocerebellar ataxias (SCAs). Studies investigating autonomic deficits in SCAs are fragmented, with each one focusing on different autonomic dysfunctions and different SCA subtypes.

Methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we conducted a systematic review of the literature to assess the presence of autonomic dysfunctions in various SCAs. PubMed served as the primary database, and the Rayyan web application was employed for study screening.

Results
We identified 46 articles investigating at least one autonomic function in patients with SCA. The results were analyzed and categorized based on the genetic subtype of SCA, thereby characterizing the specific autonomic deficits associated with each subtype.

Conclusion
This review confirms the presence of autonomic dysfunctions in various genetic subtypes of SCA, underscoring the cerebellum's role in the autonomic nervous system (ANS). It also emphasizes the importance of investigating these functions in clinical practice.
HK-2 cell response to TGF-β highly depends on cell culture medium formulations
Authors: Garmaa Gantsetseg , Manzéger Anna , Haghighi Samaneh , Kökény Gábor 
Published: September 2023

AbstractThe immortalized human renal proximal tubular epithelial cell line HK-2 is most commonly used to study renal cell physiology and human kidney diseases with tubulointerstitial fibrosis such as diabetic nephropathy, obstructive uropathy or allograft fibrosis. Epithelial-to-mesenchymal transition (EMT) is the main pathological process of tubulointerstitial fibrosis in vitro. Transforming growth factor-beta (TGF-β) is a key inducer of EMT. Several pro-fibrotic gene expression differences have been observed in a TGF-β-induced EMT model of HK-2 cells. However, growth conditions and medium formulations might greatly impact these differences. We investigated gene and protein expression of HK-2 cells cultured in six medium formulations. TGF-β1 increased the expression of ACTA2, TGFB1, COL4A1, EGR2, VIM and CTGF genes while reducing PPARG in all medium formulations. Interestingly, TGF-β1 treatment either increased or decreased EGR1, FN, IL6 and C3 gene expression, depending on medium formulations. The cell morphology was slightly affected, but immunoblots revealed TGFB1 and vimentin protein overexpression in all media. However, fibronectin expression as well as the nuclear translocation of EGR1 was medium dependent. In conclusion, our study demonstrates that, using the HK-2 in vitro model of EMT, the meticulous selection of appropriate cell culture medium formulation is essential to achieve reliable scientific results.
Larval morphology of Frostius pernambucensis (Anura): contribution of larval characters for the systematics of the family Bufonidae and evolution of endotrophic tadpoles
Authors: Dubeux Marcos Jorge Matias , do Nascimento Filipe Augusto Cavalcanti , Dias Pedro Henrique dos Santos 
Published: September 2023

AbstractFrostius pernambucensis is a phytotelm-breeding frog with endotrophic larvae. Although the larvae were formally described, no aspect of its internal morphology is known. In this paper, we re-describe the tadpole based on a large sample, describe its internal anatomy (buccopharyngeal cavity and musculo-skeletal system), provide data on natural history, and discuss the evolution of endotrophy and phytotelma colonization. The tadpoles of F. pernambucensis are highly modified, with depressed bodies, reduced mouthparts, and long tails. Many character-states described for these tadpoles can be related to its endotrophic development. Consequence of this highly modified phenotype, we propose several novel putative synapomorphies for the genus: (1) labial tooth row formula 1/1; (2) absence of pustulation in the buccal roof and (3) floor; (4) absence of median ridge; (5) absence of lateral ridge papillae; (6) absence of secretory ridges and pores; (7) absence of filter plates; (7) m. subarcualis rectus II–IV originating on ceratobranchial III; (8) m. subarcualis rectus II–IV inserting on ceratobranchial I; (8) ventral slip of the m. subarcualis rectus I inserting on the ceratobranchial III; (9) suprarostral corpora fused to the cornua trabeculae; (10) commissura quadratoorbitalis absent; (11) cerabranchial II attached to the planum hypobranchiale; and (12) ceratobranchial III attached to the planum hypobranchiale. Finally, we also propose that the presence of a single pair of infralabial papilla could represent a synapomorphy of bufonids. The colonization of phytotelma seem to have created a selective pression on the development of F. pernambucenis, favoring the evolution of endotrophy.
Enhancing resilient coping strategies for quality of life in Chinese adult children caregiving for parents with advanced cancer: a cross-sectional study
Authors: Chen Xian , Qiao Chengping , Arber Anne , Shen Yan , Rui Yehao , Zhang Rui , Pei Zhongling , Tang Yuanyuan , Sha Ziyu , Bao Jianying , Zhang Jia , Li Jinhua , Wang Dan , Wang Xuemei 
Published: September 2023

Abstract
Purpose
This study investigated the mediating role of individual resilience in the relationship between caregiver burden and quality of life (QoL) among Chinese adult children providing care to their parents with advanced cancer, with the aim to inform effective coping strategies and positive caregiving outcomes.

Methods
In a cross-sectional design, 614 caregivers from multiple centers, whose parents were undergoing chemotherapy and/or radiotherapy, completed questionnaires encompassing demographics, caregiver burden, symptoms of anxiety and depression, resilience, and QoL.

Results
Findings revealed a moderate level of caregiver burden among participants, significantly influenced by factors including education level, family income, single-child status, and participation in social media patient support groups. Caregivers who were only children or involved in patient support groups reported higher burden. Importantly, path analysis showed a significant impact of caregiver burden, anxiety, and depression on QoL, with these relationships being mediated by individual resilience.

Conclusions
Chinese adult child caregivers face a considerable burden, negatively influencing their QoL. Individual resilience, a modifiable factor, was identified as a critical mediator in this relationship, mitigating the negative implications of caregiver burden, anxiety, and depression. These findings underscore the need for caregiver interventions that consider not only demographics but also the socio-psychological dynamics of caregiving to enhance caregiver QoL.
Immunoliposomes for detection of rupture-prone intracranial aneurysms
Authors: Jahromi Behnam Rezai , Zamotin Vladimir , Code Christian , Netti Eliisa , Lorey Martina B. , Alitalo Kari , Öörni Katariina , Laakso Aki , Tulamo Riikka , Niemelä Mika 
Published: September 2023

Abstract
Background
It is estimated that significant (3.2%) of population carries intracranial aneurysm (IA). An increasing number of imaging studies have caused that the chance of finding an incidental aneurysm is becoming more common. Since IA rupture causes subarachnoidal hemorrhage (SAH) and have significant mortality and morbidity prophylactic treatment should be considered when IA is detected. The benefit and risk of treatment of IA is based on epidemiological estimate which takes account patient and aneurysm characteristics. However we know that aneurysm rupture is biological process where inflammation of aneurysm wall is actively leading to degeneration of aneurysm wall and finally weakens it until it bursts. Until now, there have not been imaging method to detect inflammatory process of aneurysm wall

Methods
We created targeting immunoliposome for use in the imaging of aneurysm. Immunoliposome comprises antibodies against at least one vascular inflammatory marker associated with aneurysm inflammation and a label and/or a contrast agent.

Results
Histological analysis of IAs where immunoliposome comprises antibodies against vascular inflammation with a label shows promising results for selectively detecting aneurysms inflammation. In magnetic resonance imaging (MRI) we were able to detect immunoliposomes carrying gadolinium.

Conclusion
Our work opens a new avenue for using contrast labeled immunoliposomes for detecting rupture-prone aneurysms. Immunoliposomes can cary gadolinium and selectively bind to inflammatory section of aneurysm that can be detected with MRI. Further research is needed to develop immunoliposomes to be used with MRI in humans to target treatment to those patients who benefit from it the most.
Identity, sociality and mobility: understanding internal fisher migration along India’s east coast
Authors: Rao Nitya , Sophia J. D 
Published: September 2023

AbstractFisher movement in the pursuit of fish is a well-established truism. In this paper, we explore the motivations and mechanisms deployed for internal migration within the fishing sector in coastal Tamil Nadu, rather than only on the seas, as a strategy for both economic and social mobility. Marine fisheries in India is a caste-based occupation, with its own social and political hierarchy, responsible for the governance and management of common resources. For those belonging to the subordinate fishing castes, excluded from decision-making processes, migration is an important strategy for gaining economic resources, social power and recognition as skilled and successful marine fishermen. Using qualitative research methods, the paper explores the migration of fishermen from Rajakuppam, a small fishing village in Cuddalore district, belonging to such a subordinate fishing caste, to Kasimedu, in the capital city of Chennai, the largest fishing harbour in the state of Tamil Nadu. We find that family and its social organization, in particular kinship and marriage ties, brokered by senior women, are significant factors in facilitating successful migration. Recognizing women’s contributions to the sector, both direct and through their social reproductive and networking activities, invisible in both the larger maritime literature and production-centric fisheries’ policy-making, is crucial for achieving wellbeing and sustainability outcomes.
Harmonising and standardising military airworthiness in Europe: a review of key aspects and achievements
Authors: Pittini M. , Kourousis K.I. 
Published: September 2023

AbstractThe distinct operational characteristics of military aircraft, relative to civil aircraft, have impeded the standardisation of airworthiness management practice across Europe. Standardisation has been further deterred by the intertwined certification and qualification activities specific to military aircraft. The management of airworthiness in European military aviation has undergone significant changes over the past 15 years, with the progress made attributed to the harmonisation efforts driven by the European Defence Agency (EDA). The creation of a Military Airworthiness Authorities Forum and the development of the European Military Airworthiness Requirements (EMAR) have been instrumental in creating a more homogenous regulatory landscape. The examples of five main players of the European aerospace sector, namely France, Italy, Germany, Spain and the United Kingdom, are examined from the point of view of adoption and implementation of an EMARs-based system. Their regulatory structures have revealed similarities and primary differences. The EMAR’s framework has enabled a gradual build-up of technical knowhow within the European countries who embraced this, civil-based, framework. All five countries have adopted EMARs, though through a variety of regulatory constructs. Their regulatory structures exhibit diverse practices, especially in how initial and continuing airworthiness is managed. Some countries have also elected to have more than one authority overseeing/been responsible for airworthiness. Closer collaboration between national Military Aviation Authorities (MAAs) can be achieved through standardisation at regulatory structure level. The establishment of a joint MAAs may be the next logical step in the harmonisation process, in line with EDA objective’ for a EU-wide authority with greater powers.
Coupled Cycling of Carbon and Water in the Form of Hydrous Carbonatitic Liquids in the Subarc Region
Authors: Chen Wei , Keshav Shantanu , Peng Weigang , Zhang Guoliang 
Published: September 2023

AbstractThe melting behavior of subducted ophicarbonate is experimentally investigated under conditions relevant for slabs at subarc depths (2.5–6 GPa and 650–1000°C). Hydrous carbonatitic liquids appear between 900 and 950°C at 2.5 GPa, between 800 and 850°C at 4–5 GPa, and at ∼800°C over 6 GPa. Water significantly depresses the thermal stability of carbonate, which drives the formation of hydrous carbonatitic liquid at low temperatures realistic for most subduction zones. Ophicarbonate fully dehydrates prior to wet melting. From an experimental point of view, the melting of ophicarbonate is essentially equal to the fluid–present melting of magnesite–bearing wehrlite lithology (i.e., meta–ophicarbonate). In the natural subduction process, the melting of meta–ophicarbonate occurs only when external water is available assuming dehydration fluid by ophicarbonate has been efficiently expelled at shallower depths. In the framework of the previously constructed dehydration history of subducting slab, the flux melting of meta–ophicarbonate at the slab–mantle interface is examined to be feasible under majority of geothermal conditions, even in cold subduction zones. Thus, hydrous carbonatitic liquid acts as a pervasive agent to transfer carbon from the slab surface to the mantle wedge at shallow depths beneath arcs. In contrast, ophicarbonate within the slab–serpentinized mantle just undergoes dehydration, and the vast majority of carbon retained in these lithologies is likely transported deeper into the mantle.
Trend and Drivers of Satellite‐Detected Burned Area Changes Across Arctic Region Since the 21st Century
Authors: Xing JiaWen , Wang MengMeng 
Published: September 2023

AbstractThe Arctic has experienced the frequent and severe fires in recent years. Due to the unique geography and vegetation type in Arctic region, the fire trend and its driving mechanism are different from other regions and still unclear. This study investigated the fire trends across Arctic region based on Moderate‐resolution Imaging Spectroradiometer (MODIS) burned area product MCD64A1 during 2001–2020. In addition, the burned area change was attributed at spatial and temporal scales based on 15 natural and anthropogenic factors. Results show that the average burned area in Arctic region during 2001–2020 is 31.2 × 103 km2, with a maximum of 51.9 × 103 km2 in 2019. The change of burned area in Arctic region is spatially heterogeneous, with a significant increasing trend (Z > 1.96) in central Russia and a significant decreasing trend (Z < −1.96) in western Russia. There is a clear seasonality in the occurrence of fires in the Arctic, with a peak in the summer months and almost no fires in the winter. Relative humidity has the largest explanatory power for the spatial variation of burned area (q = 0.487), followed by vapor pressure deficit (q = 0.475) and land surface temperature (q = 0.367). The combined effect of precipitation and land surface temperature is the most powerful interaction (q = 0.587) to explain the spatial variation of burned area. The significant increase in time‐series burned area is primarily driven by the decrease of relative humidity. The results of this study are helpful to understand the fire trends and the contribution of climate change to Arctic fires.
Thrace Basin—An Oligocene Clastic Basin Formed During the Exhumation of the Rhodope Complex
Authors: Okay Aral I. , Özcan Ercan , Siyako Muzaffer , Bürkan Kerem A. , Kylander‐Clark Andrew R. C. , Bidgood Michael D. , Shaw David , Simmons Michael D. 
Published: September 2023

AbstractSome orogenic sedimentary basins are difficult to assign to a particular category. An example is the hydrocarbon‐bearing Thrace Basin in the northern Aegean. It has more than 9‐km‐thick Cenozoic clastic sediment, and is spatially associated with the Rhodope metamorphic core complex in the west, and with the Tethyan subduction‐accretion complexes in the south, and is cut by the North Anatolian Fault and its precursors. It has been interpreted variously as an intramontane, a forearc, or an orogenic collapse basin. Here, we provide new geochronological and biostratigraphic data to constrain the tectonic evolution of the Thrace Basin. The new data indicate that as an individual depocenter the Thrace Basin has a short age span (late Eocene—Oligocene, 36–28 Ma) and more than 90% of the basin fill consists of early Oligocene (34–28 Ma) siliciclastic turbidites, deposited at rates of 1.0 km/my. Paleocurrents and new detrital zircon U‐Pb ages show that the Rhodope Complex was the main sediment source. The exhumation of the northern Rhodope Complex (36–28 Ma) was coeval with the main subsidence in the Thrace Basin (34–28 Ma), and involved clockwise crustal rotation in the northern Aegean and possibly crustal flow from underneath the Thrace Basin. Crustal rotation is indicated by the paleomagnetic data, regional stretching lineations in the Rhodope Complex, and the triangular shape of the Thrace Basin. The rotating crustal block must have been bounded in the south by a sinistral fault zone; the location of which corresponds largely with the present day North Anatolian Fault.