bluuebunny/crossref_metadata_2025_split huggingface dataset:
The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration
Authors: Yang Mei , Peng Guang-hua 
Published: April 2023

AbstractExtracellular vesicles (EVs), including microvesicles (MVs) and exosomes, play a critical role in metabolic regulation and intracellular communication. Stem cell-derived EVs are considered to have the potential for regeneration, like stem cells, while simultaneously avoiding the risk of immune rejection or tumour formation. The therapeutic effect of stem cell-derived EVs has been proven in many diseases. However, the molecular mechanism of stem cell-derived EVs in retinal repair and regeneration has not been fully clarified. In this review, we described the biological characteristics of stem cell-derived EVs, summarized the current research on stem cell-derived EV treatment in retinal repair and regeneration, and discussed the potential and challenges of stem cell-derived EVs in translational medicine.
Therapeutic potential of MSCs and MSC-derived extracellular vesicles in immune thrombocytopenia
Authors: Wu Feifeng , She Zhou , Li Cuifang , Mao Jueyi , Luo Senlin , Chen Xiaoyu , Tian Jidong , Wen Chuan 
Published: April 2023

AbstractImmune thrombocytopenia (ITP) is an acquired autoimmune disease involving a variety of immune cells and factors. Despite being a benign disease, it is still considered incurable due to its complex pathogenesis. Mesenchymal stem cells (MSCs), with low immunogenicity, pluripotent differentiation, and immunomodulatory ability, are widely used in a variety of autoimmune diseases. In recent years, impaired bone marrow mesenchymal stem cells (BMMSCs) were found to play an important role in the pathogenesis of ITP; and the therapeutic role of MSCs in ITP has also been supported by increasing evidence with encouraging efficacy. MSCs hold promise as a new approach to treat or even cure refractory ITP. Extracellular vesicles (EVs), as novel carriers in the “paracrine” mechanism of MSCs, are the focus of MSCs. Encouragingly, several studies suggested that EVs may perform similar functions as MSCs to treat ITP. This review summarized the role of MSCs in the pathophysiology and treatment of ITP.
Well posedness for one class of elliptic equations with drift
Authors: Ospanov Kordan N. 
Published: April 2023

AbstractWe studied one class of second-order elliptic equations with intermediate coefficient and proved that the semi-periodic problem on a strip is unique solvable in Hilbert space. We assume that the intermediate coefficient of the equation is continuously differentiable and grows rapidly near infinity, for example, it grows faster than $(|x|+1 ) \ln (|x|+3)$
(
|
x
|
+
1
)
ln
(
|
x
|
+
3
)
. However, we do not impose bounds on its derivatives. We believe that the lower-order coefficient is continuous, can be unlimited and change sign.
The effect of problem-solving and assertiveness training on self-esteem and mental health of female adolescents: a randomized clinical trial
Authors: Golshiri Parastoo , Mostofi Alireza , Rouzbahani Shiva 
Published: April 2023

Abstract
Background
Children and adolescents are the assets of the society and their mental and physical health ensures the future health of next generations. The aim of the current study was to evaluate the effect of problem-solving and assertiveness skill training on improving self-esteem and mental health in high school female students of Isfahan city in 2019.

Methods
This study was a randomized clinical trial. The target population was 10th grade female high school students in Isfahan city of Iran. 96 students of a female public high school were included in the study, allocated to two groups, 32 for intervention group and 64 for control group. Six 90-min sessions were considered for problem-solving and assertiveness skill training which included lectures, question and answer, movie displaying, brainstorming and role-play. The Coopersmith Self-esteem Inventory Questionnaire (CSEI) and General Health Questionnaire (GHQ) were used in order to evaluate the variables of the study before and one month after the intervention.

Results
Mean scores of the self-esteem variable changed significantly in the intervention group compared to control group before (25.2 ± 2.905) and after (29.9 ± 4.155) the intervention (p < 0.05). Mean scores of mental health also changed significantly before (27.67 ± 5.42) and after (19.033 ± 4.9) the intervention in comparison with the control group (p < 0.05).

Conclusion
The findings of the present study showed that educational intervention based on problem-solving and assertiveness can enhance self-esteem and mental health in students. Future studies are needed to confirm and determine the structure of these associations.

Trial Registration IRCT Code: IRCT20171230038142N9. Registration Date: 07/07/2019. Ethics Code: IR.MUI.MED.REC.1398.130.
The deconstruction of emotional identity of recreation for ethnic cultural heritage in the geo-cultural perspective: a fuzzy set qualitative comparative analysis on Wuqiang new year paintings
Authors: Feng Xin , Yu Lei , Chen Guoqiang 
Published: April 2023

Abstract
As a model of the combination of nostalgia and creative products, ethnic cultural heritage carry the function of shaping and spreading geo-culture. Its unique geo-cultural context, as a link, shows the historical inheritance of local culture. The deep deconstruction of its emotional identity helps to strengthen this identity and stimulate more cultural and creative designs with national and local characteristics. While culture prospers, the local cultural and creative economy is strengthened and cultural confidence and national self-confidence are further enhanced. Based on the New Year paintings of Wuqiang in Hebei, which have a strong folk vernacular and geo-cultural character in northern China, in the process of using the reconstructed pattern elements for clothing design, 156 questionnaires were collected through questionnaire interviews and fsQCA was used to analyze the emotional identity of products with high geo-cultural recognition. The study finds that while the injection of regional culture plays a role in the development of products, people's emotional identification with vernacular cultural and creative products actually depends on a combination of causal paths, with beauty and elegance more important than place and humanity as commonly believed to reflect geographic cultural identity. fsQCA was used to analyze the emotional identity of products with high geo-cultural recognition. And understand the emotional components of vernacular cultural products and how emotional factors influence people's identities.
A randomized porcine study of hemorrhagic shock comparing end-tidal carbon dioxide targeted and proximal systolic blood pressure targeted partial resuscitative endovascular balloon occlusion of the aorta in the mitigation of metabolic injury
Authors: Stene Hurtsén Anna , McGreevy David T. , Karlsson Christina , Frostell Claes G. , Hörer Tal M. , Nilsson Kristofer F. 
Published: April 2023

Abstract
Background
The definition of partial resuscitative endovascular balloon occlusion of the aorta (pREBOA) is not yet determined and clinical markers of the degree of occlusion, metabolic effects and end-organ injury that are clinically monitored in real time are lacking. The aim of the study was to test the hypothesis that end-tidal carbon dioxide (ETCO2) targeted pREBOA causes less metabolic disturbance compared to proximal systolic blood pressure (SBP) targeted pREBOA in a porcine model of hemorrhagic shock.

Materials and methods
Twenty anesthetized pigs (26–35 kg) were randomized to 45 min of either ETCO2 targeted pREBOA (pREBOAETCO2, ETCO2 90–110% of values before start of occlusion, n = 10) or proximal SBP targeted pREBOA (pREBOASBP, SBP 80–100 mmHg, n = 10), during controlled grade IV hemorrhagic shock. Autotransfusion and reperfusion over 3 h followed. Hemodynamic and respiratory parameters, blood samples and jejunal specimens were analyzed.

Results
ETCO2 was significantly higher in the pREBOAETCO2 group during the occlusion compared to the pREBOASBP group, whereas SBP, femoral arterial mean pressure and abdominal aortic blood flow were similar. During reperfusion, arterial and mesenteric lactate, plasma creatinine and plasma troponin concentrations were higher in the pREBOASBP group.

Conclusions
In a porcine model of hemorrhagic shock, ETCO2 targeted pREBOA caused less metabolic disturbance and end-organ damage compared to proximal SBP targeted pREBOA, with no disadvantageous hemodynamic impact. End-tidal CO2 should be investigated in clinical studies as a complementary clinical tool for mitigating ischemic–reperfusion injury when using pREBOA.
Single-incision laparoscopic surgery for intestinal intussusception due to neuroendocrine tumor
Authors: Sueda Toshinori , Tei Mitsuyoshi , Mori Soichiro , Nishida Kentaro , Yasuyama Akinobu , Yoshikawa Yukihiro , Nomura Masatoshi , Koga Chikato , Miyagaki Hiromichi , Tsujie Masanori , Akamaru Yusuke 
Published: April 2023

Abstract
Background
Small intestinal neuroendocrine tumor (NET) is uncommon, but intestinal intussusception caused by NET is even rare. We report a rare case of single-incision laparoscopic surgery (SILS) for intestinal intussusception due to NET G1.

Case presentation
A 72-year-old woman presented with vomiting, diarrhea, and abdominal pain. Contrast-enhanced computed tomography (CT) revealed the target sign in the ascending colon. An enhanced nodule was detected at the lead point, leading us to suspect a tumor. Colonoscopy showed a tumor at the lead point of the intestinal intussusception. Histological findings led to a diagnosis of NET G1. Single-incision laparoscopic ileocecal resection with regional lymphadenectomy was then performed. The patient was discharged 10 days postoperatively with no complications.

Conclusion
We achieved SILS with regional lymphadenectomy for preoperatively diagnosed intestinal intussusception due to NET G1. Although this condition is rare, surgeons should take this possibility into consideration in cases showing similar findings.
Extracting topological features to identify at-risk students using machine learning and graph convolutional network models
Authors: Albreiki Balqis , Habuza Tetiana , Zaki Nazar 
Published: April 2023

AbstractTechnological advances have significantly affected education, leading to the creation of online learning platforms such as virtual learning environments and massive open online courses. While these platforms offer a variety of features, none of them incorporates a module that accurately predicts students’ academic performance and commitment. Consequently, it is crucial to design machine learning (ML) methods that predict student performance and identify at-risk students as early as possible. Graph representations of student data provide new insights into this area. This paper describes a simple but highly accurate technique for converting tabulated data into graphs. We employ distance measures (Euclidean and cosine) to calculate the similarities between students’ data and construct a graph. We extract graph topological features (GF) to enhance our data. This allows us to capture structural correlations among the data and gain deeper insights than isolated data analysis. The initial dataset (DS) and GF can be used alone or jointly to improve the predictive power of the ML method. The proposed method is tested on an educational dataset and returns superior results. The use of DS alone is compared with the use of $$DS + GF$$

D
S
+
G
F

in the classification of students into three classes: “failed”,“at risk”, and “good”. The area under the receiver operating characteristic curve (AUC) reaches 0.948 using DS, compared with 0.964 for $$DS + GF$$

D
S
+
G
F

. The accuracy in the case of $$DS + GF$$

D
S
+
G
F

varies from 84.5 to 87.3%. Adding GF improves the performance by 2.019% in terms of AUC and 3.261% in terms of accuracy. Moreover, by incorporating graph topological features through a graph convolutional network (GCN), the prediction performance can be enhanced by 0.5% in terms of accuracy and 0.9% in terms of AUC under the cosine distance matrix. With the Euclidean distance matrix, adding the GCN improves the prediction accuracy by 3.7% and the AUC by 2.4%. By adding graph embedding features to ML models, at-risk students can be identified with 87.4% accuracy and 0.97 AUC. The proposed solution provides a tool for the early detection of at-risk students. This will benefit universities and enhance their prediction performance, improving both effectiveness and reputation.
Utility of anti-immunoglobulin IgA, IgG, IgM, Kappa, Lambda - FITC (conjugate) cocktail in routine renal pathology practice
Authors: Thakur Shilpi , Gaspar Balan Louis 
Published: April 2023

Abstract
Background
Immunofluorescence studies on frozen sections are an essential component in the evaluation of renal biopsies. The basic panel in most centres constitutes IgG, IgA, IgM, C3c, C1q, Kappa and Lambda light chain antibody testing. The purpose of this panel is to detect immunoglobulin or complement deposits and further subclassify the disease based on the location, intensity and pattern of immunoglobulin and complement staining. However, there are a substantial proportion of nephropathies that do not show any obvious immune-deposits on immunofluorescence. We currently, do not have any evidence-based alternative immunofluorescence panel to rule out these conditions. This study aims to evaluate the utility of anti-immunoglobulin IgA, IgG, IgM, Kappa, Lambda - FITC cocktail immunofluorescence on renal biopsy frozen sections with emphasis on its role as a primary screening panel in conjunction with C3c and C1q.

Methods
Anti-immunoglobulin IgA, IgG, IgM, Kappa, Lambda light chain - FITC cocktail immunofluorescence was performed on 593 consecutive native renal biopsies along with the routine panel comprising of the individual FITC labelled IgG, IgA, IgM, C3c, C1q, Kappa and Lambda light chain immunofluorescence stains.

Results
In 235 (39.6%) cases immune deposits (immune-complex mediated and monoclonal gammopathy-related) were present and the rest 354 (59.7%) cases were negative for immunoglobulin or complement deposits. Overall, the sensitivity, specificity, positive predictive value and negative predictive values of anti-immunoglobulin IgA, IgG, IgM, Kappa and Lambda - FITC cocktail in distinguishing immune-complex/immunoglobulin-mediated glomerulopathies from non-immune complex/immunoglobulin-mediated glomerulopathies were 100% each.

Conclusion
Anti-immunoglobulin IgA, IgG, IgM, Kappa and Lambda - FITC cocktail when used in conjunction with C3c and C1q, can be an effective first line investigation in all native renal biopsies. Further, testing with the individual FITC labelled IgG, IgA, IgM, Kappa and Lambda light chain immunofluorescence can be performed, depending on the initial screening as described above. Overall, this algorithmic approach can save valuable resources.
Dietary patterns associated with the risk of osteoporosis in postmenopausal women
Authors: Tayyem Reema F. , Ajeen Rawan , Al-Khammash Amal 
Published: April 2023

AbstractThe purpose of this study is to investigate the association between dietary patterns and the risk associated with osteoporosis in Jordanian postmenopausal women recently diagnosed with osteoporosis. A case–control study design was used to determine nutrient intake, and dietary and lifestyle patterns. Two hundred Jordanian postmenopausal women were enrolled; 100 patients newly diagnosed with osteoporosis, and 100 osteoporosis-free controls, according to the inclusion criteria. Case and control groups were selected from visitors to the University of Jordan Hospital and the Jordanian Osteoporosis Prevention Society. The case-to-control ratio was (1:1). Four dietary patterns were identified in this study and they include: ‘High-Fruits and Vegetables', 'Traditional', 'Unhealthy/Western', and 'High-Proteins', which accounted for 44.7% of the total variance in food intake. The ‘High-Fruits and Vegetables’ dietary pattern showed a decreased likelihood of osteoporosis risk in the fourth quartile [Q4: AOR 0.375, 95% CI (0.154–0.9150), P = 0.031]. On the other hand, the ‘Unhealthy/Western’ and ‘High-Protein’ dietary patterns were positively associated ([Q3: AOR 2.834, 95%CI (1.081–7.430), P = 0.034] and [AQ3: OR 2.601, 95% CI (1.983–6.882), P = 0.045], respectively) with osteoporosis risk in the third quartile. The present results suggest that the 'High-Fruits and Vegetables' dietary pattern may exert a protective effect on the risk of osteoporosis while 'Unhealthy/Western' and 'High-Protein' dietary patterns showed positive effects on the risk of osteoporosis.
Graphical Abstract
Infantile hepatic hemangioendothelioma associated with pulmonary arterial hypertension and cardiac insufficiency successfully treated with oral propranolol—a rare case report
Authors: Priyadarshini Debashree , Akhila Goolla , Sarangi Rachita , Mahapatra Anuspandana 
Published: April 2023

Abstract
Background
Infantile hepatic hemangioendothelioma (IHHE) is a benign liver tumor associated with a varied spectrum of presentations ranging from asymptomatic hepatomegaly and cutaneous hemangiomas to some life-threatening complications like cardiac failure, consumptive hypothyroidism, pulmonary arterial hypertension, gastrointestinal bleeding, and coagulopathy. Hypothyroidism results from increased activity of type 3 iodothyronine deiodinase in the liver. Clinico-radiological correlation is essential for a definite diagnosis. Although children with asymptomatic lesions may experience spontaneous regression within a year, those with symptomatic lesions require aggressive management due to the risk of mortality once the symptoms commence. Treatment modalities can be either pharmacologic or interventional depending on the clinical presentation, with propranolol being considered the first-line agent.

Case presentation
Here, we describe a 2-month-old female infant with progressive abdominal distension, signs of congestive cardiac failure, and pulmonary arterial hypertension, confirmed as IHHE by abdominal ultrasonography and contrast-enhanced MRI. It was complicated by consumptive hypothyroidism and coagulopathy. The child was successfully treated with oral propranolol, levothyroxine, and supportive measures.

Conclusion
Early aggressive treatment in a symptomatic patient is linked to successful outcomes. Hypothyroidism should be focused on and managed earlier to prevent intellectual and growth retardation.
Mosquito larvicidal, pupicidal and ovidical effects of the different extracts of the leaves of Peltophorum pterocarpum against Aedes aegypti and Culex quinquefasciatus
Authors: Yagoo Alex , Milton M. C. John , Vilvest Jelin , Johnson Irine , Balakrishna Keduki 
Published: April 2023

Abstract
Background
Mosquitoes are vectors for several diseases like dengue, chikingunea, malaria etc. The three important mosquito species in India are Aedes aegypti, Culex quinquefasciatus and Anopheles stephensi. Several plant extracts and phytoconstituents have been tested for antimosquito activity. In our present investigation, we have studied, the mosquito larvicidal, pupicidal and ovicidal activities of the successive n-hexane, chloroform and methanol extracts of leaves of Peltophorum pterocarpum (Fabaceae).

Results
The two mosquito species studied were Ae. agypti and Cx. quinquefasiatus. The larvicdial activity on both mosquitoes was in the order methanol > chloroform > n-hexne. The LC 50 values for these extracts were 111.77 and 158.93 ppm (methanol extract), 170.74 and 169.18 ppm (chloroform extract), 219.14 and 203.48 ppm (n-hexane) respectively for both mosquitoes. The pupicidal activity was in the order chloroform > methanol > n-hexne. The LC50 values for these extracts were 226.01 and 204.041 ppm (chloroform extract), 235.40 and 239.50 ppm (methanol extract), 303.07 and 284.04 ppm (n-hexane,) respectively. The ovicidal activity of the extracts against both the mosquitoes studied was not appreciable.

Conclusion
The methanol extract revealed higher larvicidal activity, while the chloroform extract showed higher pupicidal activity for both the mosquitoes. Hence, the methanol and chloroform extracts of the leaves of the plant may be taken up for further studies. This is the first detailed report on the antimosquito activity of the successive extracts of the leaves of Peltophorum perocarpum against the two mosquito species Ae. aegypti and Cx. quinquefasciatus.
CLUSTER APPROACH IN THE DEVELOPMENT OF SMALL AGRIBUSINESS SUBJECTS
Authors: Mikhaylova Valerikovna 
Published: April 2023

The number of small agricultural business entities includes agricultural enterprises of various organizational and legal forms (with the exception of state and municipal enterprises, dependent and subsidiaries and partnerships), as well as agricultural consumer cooperatives, peasant (farmer) households, and household households. At present, the small agricultural business of the Republic of Tatarstan is represented by over 470 thousand personal, about 3 thousand farms and more than 300 agricultural consumer cooperatives. Personal subsidiary farms use
1 499.3 thousand hectares of agricultural land, and private farms own more than 312 thousand hectares of arable land, or 9% of the area of the entire arable land of the republic. If we consider the share of small agribusiness entities in the structure of the region's economy, then almost half of the gross agricultural output falls on them. To improve the efficiency of small agribusiness, the further development of small enterprises is associated with their clustering. This article examines the advantages of the cluster approach in the activities of small agricultural businesses. The clustering of small agribusiness entities opens up more opportunities for expanded production. Small enterprises that are members of the agro-industrial cluster increase their competitiveness and position in the commodity market. Functioning within clusters can contribute to the production of goods, endowing them with other properties and, accordingly, conquering new market niches. The stable development of regions, economic growth in production in many areas of the agro-industrial complex in recent years create real prerequisites for the creation of local clusters. Compared to Russia, in developed countries, clusters have been created for decades and, importantly, they show real profitability, as well as the inclusion of organizations in such clusters contribute to the exchange of experience in doing business. For the further development of small businesses, it is necessary to use a cluster approach, the advantages of which are the expansion of sales markets for products, the full cycle of production of finished products, savings with large volumes of purchases.