bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simulation-based option to assess data-limited fisheries off West African waters
Authors: Kindong Richard , Wu Feng , Sarr Ousmane , Zhu Jiangfeng 
Published: September 2023

AbstractMost sophisticated stock assessment models often need a large amount of data to assess fish stocks, yet this data is often lacking for most fisheries worldwide, resulting in the increasing demand for data-limited stock assessment methods. To estimate fish stock status, one class of these data-limited methods uses simply catch time series data and, in other instances, life history information or fishery characteristics. These catch-only methods (COMs) built differently are known to make assumptions about changes in fishing effort and may perform differently under various fishing scenarios. As a case study, this paper used European anchovy (Engraulis encrasicolus) caught in the northwest African waters, though very economically and ecologically important, but still unassessed. Our study investigated the performance of five COMs under different fishing scenarios using as a reference the life-history information of the European anchovy captured in this region of the Atlantic. Hence, the present study developed a simulation approach to evaluate the performance of the five COMs in inferring the stock biomass status (B/BMSY) with consideration of different fishing scenarios under prior information true to anchovy. All five COMs mostly underestimated B/BMSY throughout the simulation period, especially under constant fishing mortality, and in the last five years of the simulation during all fishing scenarios. Overall, these COMs were generally poor classifiers of stock status, however, the state-space COM (SSCOM) generally performed better than the other COMs as it showed possibilities of recovering an overfished stock. When these methods were explored using actual anchovy catch data collected in the northwest African waters, SSCOM yielded results that were deferred from the other COMs. This study being the first to assess this species’ stock in this area using a suite of COMs, presents more insights into the species stock status, and what needs to be considered before scientifically putting in place management measures of the stock in the area.
IL-1β stimulated human umbilical cord mesenchymal stem cells ameliorate rheumatoid arthritis via inducing apoptosis of fibroblast-like synoviocytes
Authors: Chiu Yun-Hsuan , Liang Ya-Han , Hwang Jeng-Jong , Wang Hwai-Shi 
Published: September 2023

AbstractRheumatoid arthritis (RA) is characterized by synovial proliferation and lymphocyte accumulation leading to progressive damage of the periarticular bone and the articular cartilage. The hyperplasia of the synovial intima lining mainly consists of fibroblast-like synoviocytes-rheumatoid arthritis (HFLS-RA) which exhibit apoptosis-resistance, hyper-proliferation, and high invasiveness. The therapeutic efficacy of mesenchymal stem cells (MSCs) treatment in RA has been shown to be due to its immuno-regulatory ability. However, the exact factors and mechanisms involved in MSCs treatment in RA remain unclear. In this study, TRAIL receptor-Death receptor 4 (DR4), DR5, and LFA-1 ligand-intercellular adhesion molecule-1 (ICAM-1) were upregulated in IL-1β-stimulated HFLS-RA. We demonstrated that the total cell number of IL-1β-stimulated hUCMSCs adhering to IL-1β-stimulated HFLA-RA increased via LFA-1/ICAM-1 interaction. Direct co-culture of IL-1β-stimulated hUCMSCs with IL-1β-stimulated HFLS-RA increased the apoptosis of HFLS-RA. RA symptoms in the CIA mouse model improved after administration of IL-1β-stimulated hUCMSCs. In conclusion, IL-1β-stimulated hUCMSCs adhering to HFLS-RA occurred via LFA-1/ICAM-1 interaction, apoptosis of HFLS-RA was induced via TRAIL/DR4, DR5 contact, and RA symptoms and inflammation were significantly improved in a CIA mouse model. The results of this study suggest that IL-1β-stimulated hUCMSCs have therapeutic potential in RA treatment.
C-reactive protein-to-albumin ratio as a biomarker in patients with sepsis: a novel LASSO-COX based prognostic nomogram
Authors: Zhou Xin , Fu Shouzhi , Wu Yisi , Guo Zhenhui , Dian Wankang , Sun Huibin , Liao Youxia 
Published: September 2023

AbstractTo develop a C-reactive protein-to-albumin ratio (CAR)-based nomogram for predicting the risk of in-hospital death in sepsis patients. Sepsis patients were selected from the MIMIC-IV database. Independent predictors were determined by multiple Cox analysis and then integrated to predict survival. The performance of the model was evaluated using the concordance index (C-index), receiver operating characteristic curve (ROC) analysis, and calibration curve. The risk stratifications analysis and subgroup analysis of the model in overall survival (OS) were assessed by Kaplan–Meier (K–M) curves. A total of 6414 sepsis patients were included. C-index of the CAR-based model was 0.917 [standard error (SE): 0.112] for the training set and 0.935 (SE: 0.010) for the validation set. The ROC curve analysis showed that the area under the curve (AUC) of the nomogram was 0.881 in the training set and 0.801 in the validation set. And the calibration curve showed that the nomogram performs well in both the training and validation sets. K–M curves indicated that patients with high CAR had significantly higher in-hospital mortality than those with low CAR. The CAR-based model has considerably high accuracy for predicting the OS of sepsis patients.
Effects of multiple cations and sintering temperature on microstructure and dielectric properties in Na1/2Ln1/2Cu3Ti4O12 (Ln = Sm and Eu) ceramic materials
Authors: Yuan Long-Fei , Zhang Ting , Han Dan-Dan 
Published: September 2023

AbstractNa1/2Eu1/2Cu3Ti4O12 and Na1/2Sm1/2Cu3Ti4O12 dielectric ceramics were synthesized at different sintering temperatures (950, 975 and 1000 °C) by a solid-state reaction method. Phase structure, cation valence state, and dielectric properties of all sintered ceramics were systematically investigated. When the preparation temperature was changed, the Cu+ ion concentration of (Na+, Eu3+) co-doped ceramics changed faster than that of (Na+, Sm3+) co-doped ceramics. Abnormally high dielectric constants of ~ 3.17 × 104 and ~ 1.06 × 104 (at 10 Hz and 303 K) were achieved in Na1/2Sm1/2Cu3Ti4O12 and Na1/2Eu1/2Cu3Ti4O12 ceramics prepared at 950 °C, respectively. However, Na1/2Sm1/2Cu3Ti4O12 and Na1/2Eu1/2Cu3Ti4O12 prepared in high sintering temperature (1000 °C) exhibited a good frequency stability of dielectric permittivity. It was demonstrated that an increasing number of charge carriers induced by the increase of sintering temperature could lead to a competitive coexistence of two polarization mechanisms (surface barrier layer capacitor and internal barrier layer capacitor), further changing the dielectric properties of CaCu3Ti4O12-based ceramics.
Meticulous research for design of plasmonics sensors for cancer detection and food contaminants analysis via machine learning and artificial intelligence
Authors: Jafrasteh Fatemeh , Farmani Ali , Mohamadi Javad 
Published: September 2023

AbstractCancer is one of the leading causes of death worldwide, making early detection and accurate diagnosis critical for effective treatment and improved patient outcomes. In recent years, machine learning (ML) has emerged as a powerful tool for cancer detection, enabling the development of innovative algorithms that can analyze vast amounts of data and provide accurate predictions. This review paper aims to provide a comprehensive overview of the various ML algorithms and techniques employed for cancer detection, highlighting recent advancements, challenges, and future directions in this field. The main challenge is finding a safe, auditable and reliable analysis method for fundamental scientific publication. Food contaminant analysis is a process of testing food products to identify and quantify the presence of harmful substances or contaminants. These substances can include bacteria, viruses, toxins, pesticides, heavy metals, allergens, and other chemical residues. Machine learning (ML) and artificial intelligence (A.I) proposed as a promising method that possesses excellent potential to extract information with high validity that may be overlooked with conventional analysis techniques and for its capability in a wide range of investigations. A.I technology used in meta-optics can develop optical devices and systems to a higher level in future. Furthermore (M.L.) and (A.I.) play key roles as a health Approach for nano materials NMs safety assessment in environment and human health research. Beside, benefits of ML in design of plasmonic sensors for different applications with improved resolution and detection are convinced.
Blast Overpressures as a Military and Occupational Health Concern
Authors: Cacace Anthony T. , Berri Batoul 
Published: September 2023

Purpose:
This tutorial reviews effects of environmental stressors like blast overpressures and other well-known acoustic contaminants (continuous, intermittent, and impulsive noise) on hearing, tinnitus, vestibular, and balance-related functions. Based on the overall outcome of these effects, detailed consideration is given to the health and well-being of individuals.

Method:

Because hearing loss and tinnitus are consequential in affecting quality of life, novel neuromodulation paradigms are reviewed for their positive abatement and treatment-related effects. Examples of clinical data, research strategies, and methodological approaches focus on repetitive transcranial magnetic stimulation (
r
TMS) and electrical stimulation of the vagus nerve paired with tones (VNS
t
) for their unique contributions to this area.

Results:

Acoustic toxicants transmitted through the atmosphere are noteworthy for their propensity to induce hearing loss and tinnitus. Mounting evidence also indicates that high-level rapid onset changes in atmospheric sound pressure can significantly impact vestibular and balance function. Indeed, the risk of falling secondary to loss of, or damage to, sensory receptor cells in otolith organs (utricle and saccule) is a primary reason for this concern. As part of the complexities involved in VNS
t
treatment strategies, vocal dysfunction may also manifest. In addition, evaluation of temporospatial gait parameters is worthy of consideration based on their ability to detect and monitor incipient neurological disease, cognitive decline, and mortality.

Conclusion:
Highlighting these respective areas underscores the need to enhance information exchange among scientists, clinicians, and caregivers on the benefits and complications of these outcomes.
Millimeter emission in photoevaporating disks is determined by early substructures
Authors: Gárate Matías , Birnstiel Til , Pinilla Paola , Andrews Sean M. , Franz Raphael , Stammler Sebastian Markus , Picogna Giovanni , Ercolano Barbara , Miotello Anna , Kurtovic Nicolás T. 
Published: September 2023

Context. Photoevaporation and dust-trapping are individually considered to be important mechanisms in the evolution and morphology of protoplanetary disks. However, it is not yet clear what kind of observational features are expected when both processes operate simultaneously.
Aims. We studied how the presence (or absence) of early substructures, such as the gaps caused by planets, affects the evolution of the dust distribution and flux in the millimeter continuum of disks that are undergoing photoevaporative dispersal. We also tested if the predicted properties resemble those observed in the population of transition disks.
Methods. We used the numerical code Dustpy to simulate disk evolution considering gas accretion, dust growth, dust-trapping at substructures, and mass loss due to X-ray and EUV (XEUV) photoevaporation and dust entrainment. Then, we compared how the dust mass and millimeter flux evolve for different disk models.
Results. We find that, during photoevaporative dispersal, disks with primordial substructures retain more dust and are brighter in the millimeter continuum than disks without early substructures, regardless of the photoevaporative cavity size. Once the photoevaporative cavity opens, the estimated fluxes for the disk models that are initially structured are comparable to those found in the bright transition disk population (Fmm > 30 mJy), while the disk models that are initially smooth have fluxes comparable to the transition disks from the faint population (Fmm < 30 mJy), suggesting a link between each model and population.
Conclusions. Our models indicate that the efficiency of the dust trapping determines the millimeter flux of the disk, while the gas loss due to photoevaporation controls the formation and expansion of a cavity, decoupling the mechanisms responsible for each feature. In consequence, even a planet with a mass comparable to Saturn could trap enough dust to reproduce the millimeter emission of a bright transition disk, while its cavity size is independently driven by photoevaporative dispersal.
Wavelet determination of magnetohydrodynamic-range power spectral exponents in solar wind turbulence seen by Parker Solar Probe
Authors: Wang X. , Chapman S. C. , Dendy R. O. , Hnat B. 
Published: September 2023

Context. The high Reynolds number solar wind flow provides a natural laboratory for the study of turbulence in situ. Parker Solar Probe samples the solar wind between 0.17 AU and 1 AU, providing an opportunity to study how turbulence evolves in the expanding solar wind.
Aims. We aim to obtain estimates of the scaling exponents and scale breaks of the power spectra of magnetohydrodynamic (MHD) turbulence at sufficient precision to discriminate between Kolmogorov and Iroshnikov-Kraichnan (IK) turbulence, both within each spectrum and across multiple samples at different distances from the Sun and at different plasma β.
Methods. We identified multiple long-duration intervals of uniform solar wind turbulence, sampled by PSP/FIELDS and selected to exclude coherent structures, such as pressure pulses and current sheets, and in which the primary proton population velocity varies by less than 20% of its mean value. The local value of the plasma β for these datasets spans the range 0.14 < β < 4. All selected events span spectral scales from the approximately ‘1/f’ range at low frequencies, through the MHD inertial range (IR) of turbulence, and into the kinetic range, below the ion gyrofrequency. We estimated the power spectral density (PSD) using a discrete Haar wavelet decomposition, which provides accurate estimates of the IR exponents.
Results. Within 0.3 AU of the Sun, the IR exhibits two distinct ranges of scaling. The inner, high-frequency range has an exponent consistent with that of IK turbulence within uncertainties. The outer, low-frequency range is shallower, with exponents in the range from –1.44 to –1.23. Between 0.3 and 0.5 AU, the IR exponents are closer to, but steeper than, that of IK turbulence and do not coincide with the value –3/2 within uncertainties. At distances beyond 0.5 AU from the Sun, the exponents are close to, but mostly steeper than, that of Kolmogorov turbulence, –5/3: uncertainties inherent in the observed exponents exclude the value –5/3. Between these groups of spectra we find examples, at 0.26 AU and 0.61 AU, of two distinct ranges of scaling within the IR with an inner, high-frequency range with exponents ∼ − 1.4, and a low-frequency range with exponents close to the Kolmogorov value of –5/3.
Conclusions. Since the PSD-estimated scaling exponents are a central predictor in turbulence theories, these results provide new insights into our understanding of the evolution of turbulence in the solar wind.
A persistent excess of galaxy-galaxy strong lensing observed in galaxy clusters
Authors: Meneghetti Massimo , Cui Weiguang , Rasia Elena , Yepes Gustavo , Acebron Ana , Angora Giuseppe , Bergamini Pietro , Borgani Stefano , Calura Francesco , Despali Giulia , Giocoli Carlo , Granata Giovanni , Grillo Claudio , Knebe Alexander , Macciò Andrea V. , Mercurio Amata , Moscardini Lauro , Natarajan Priyamvada , Ragagnin Antonio , Rosati Piero , Vanzella Eros 
Published: September 2023

Context. Previous studies have revealed that the estimated probability of galaxy-galaxy strong lensing in observed galaxy clusters exceeds the expectations from the Λ cold dark matter cosmological model by one order of magnitude.
Aims. We aim to understand the origin of this excess by analyzing a larger set of simulated galaxy clusters, and investigating how the theoretical expectations vary under different adopted prescriptions and numerical implementations of star formation and feedback in simulations.
Methods. We performed a ray-tracing analysis of 324 galaxy clusters from the THREE HUNDRED project, comparing the GADGET-X and GIZMO-SIMBA runs. These simulations, which start from the same initial conditions, were performed with different implementations of hydrodynamics and galaxy formation models tailored to match different observational properties of the intracluster medium and cluster galaxies.
Results. We find that galaxies in the GIZMO-SIMBA simulations develop denser stellar cores than their GADGET-X counterparts. Consequently, their probability for galaxy-galaxy strong lensing is higher by a factor of ∼3. This increment is still insufficient to fill the gap with observations as a discrepancy by a factor ∼4 still persists. In addition, we find that several simulated galaxies have Einstein radii that are too large compared to observations.
Conclusions. We conclude that a persistent excess of galaxy-galaxy strong lensing exists in observed galaxy clusters. The origin of this discrepancy with theoretical predictions is still unexplained in the framework of the cosmological hydrodynamical simulations. This might signal a hitherto unknown issue with either the simulation methods or our assumptions regarding the standard cosmological model.
Dossier « Recherches sur la question animale : entre mobilisations sociétales et innovations technologiques » – La mise en marché du « progrès génétique » : le cas de la sélection et de la reproduction des vaches laitières
Authors: Doré Antoine 
Published: September 2023

À partir d’une analyse sociohistorique des modalités de production, d’amplification et de distribution du « progrès génétique » dans les productions animales, cet article étudie les manières dont des scientifiques et ingénieurs évaluent, retraduisent et redistribuent les propriétés naturelles et sociales des vivants afin d’en faire des biens échangeables. Sur la base d’une courte généalogie des marchés de la sélection et de la reproduction des vaches laitières, il montre que la mise en marché de la génétique animale passe par l’instauration d’un « progrès génétique » qui ne soit affecté ni par les contingences sociales, ni par les contingences naturelles et qui puisse ainsi circuler dans une diversité de situations qu’il contribue à unifier. Il montre ensuite que le gain d’autonomie vis-à-vis d’un large panel de contingences (sociales et naturelles) suppose et engendre l’instauration d’une forte hétéronomie à l’égard d’une infrastructure sociotechnique qui supporte l’existence d’un nouvel ordre.
Le longe-côte, une activité physique de santé en pleine nature
Authors: Schwob Valerie , Jarthon Jeanne-Maud 
Published: September 2023

Le longe-côte est une pratique physique de santé mais aussi un sport de compétition. Il s’agit d’un « espace social » (Dubuisson-Quellier, S., & Plessz, M. (2013). La théorie des pratiques, Sociologie, 4(4)) encore peu questionné aujourd’hui. Dans cet article, nous nous proposons d’interroger le rapport à la nature et à la santé à travers la pratique physique du longe-côte (Corneloup, J. (2011). La forme transmoderne des pratiques récréatives de nature. Développement durable et territoires. Développement durable et territoires, 2(3), 1–15). L’approche sociologique s’appuie sur une démarche d’enquête par entretiens auprès des membres et dirigeants de l’association « Les Foulées nordiques de la Prée » située dans le département de la Charente Maritime. L’analyse thématique des entretiens (Bardin, L. (2013). L’analyse de contenu. Paris : PUF : Tessier, G. (1993). Pratiques de recherche en sciences de l’éducation. Rennes : Presses universitaires de Rennes) conduit à produire une grille d’analyse catégorielle complétée par des observations participantes (Laplantine, F. (2010) [1996]. La description ethnographique. L’enquête et ses méthodes. Paris : Armand Colin). Cette étude permet de saisir les enjeux sanitaires, sociaux et environnementaux de cette pratique émergente de pleine nature pour la population locale.
Die Interdisziplinäre Familienmedizinische Sprechstunde in
der Kinderheilkunde – Ein integrativer Ansatz für komplex
belastete Familien mit einem chronisch kranken Kind
Authors: Zumbaum-Fischer Franziska , Hartmann Mechthild , Kotzaeridou Urania , Mondry Anne , Resch Franz , Hoffmann Georg Friedrich , Friederich Hans-Christoph 
Published: September 2023

ZusammenfassungBei hochbelasteten Familien chronisch kranker Kinder ist es notwendig
psychosoziale Expertise direkt in den pädiatrischen Behandlungsprozess
einzubeziehen. Hierzu wurde in der Heidelberger
Universitätspädiatrie in einem Modellprojekt eine
interdisziplinäre Familienmedizinische Sprechstunde, besetzt mit
pädiatrischem sowie kinder- und jugendpsychiatrischem bzw.
psychosomatischem Fachpersonal, eingerichtet. Es zeigt sich, dass die
Implementierung der Sprechstunde, trotz eines hohen organisatorischen Aufwands,
funktioniert und regelmäßig in Anspruch genommen wird. Erste
Evaluationsergebnisse bestätigen die vorbeschriebenen hohen
psychosozialen Belastungswerte der Familien. Sie deuten auf eine positive
Bewertung der Sprechstunde und einen Wunsch nach dauerhaftem Angebot bei den
betroffenen Familien hin. Erste Verlaufsergebnisse weisen auf eine signifikante
Abnahme behandlungsbezogener Sorge sowie Verunsicherung und eine Reduktion
behandlungsbezogener Probleme hin. Das Fehlen eines tragfähigen
Finanzierungsmodells stellt für die dauerhaften Implementierung eine
Herausforderung dar.
Clinical Characterization and Molecular Analysis of Fourteen Chinese Patients with Factor V Deficiency
Authors: Zhang Ke , Ye Longying , Jin Yanhui , Chen Yuan , Zeng Manlin , Jia Kaiqi , Yang Lihong , Wang Mingshan 
Published: September 2023

Abstract
Introduction Coagulation factor V (FV) functions as a vital cofactor that performs procoagulant roles in the coagulation system. We investigated 14 unrelated patients whose plasma FV levels were all below the reference range.
Methods FV activity (FV:C) and FV antigen were detected by one-stage clotting and ELISA, respectively. All 25 exons of the F5 gene in patients were amplified by the PCR, and they were sequenced directly. Haplotype analysis was performed with different polymorphisms on F5. Protein modeling was applied to analyze the potential molecular mechanisms.
Results Of five patients with higher FV levels (FV:C > 10%), only one had minor bleeding symptoms. In contrast, of the remaining eight patients with lower FV levels (FV:C < 10%), six showed various bleeding manifestations. A total of 10 mutations were detected from 14 patients (6 were novel mutations). Interestingly, the homozygous p.Phe190Ser was found in five pedigrees, and haplotype analysis showed that they shared almost the same haplotype, indicating the common origin rather than a hotspot mutation. In silico analysis preliminarily investigated the potential pathogenic mechanism of the mutation. Modeling analysis showed that all six missense mutations would lead to conformational alterations in the FV protein. Among them, three (p.Gly1715Ser, p.Ser1753Arg, and p.Asp68His) would decrease hydrogen bonds.
Conclusion This is the largest genetic analysis of a single cohort of FV deficiency in Chinese. The study demonstrated that FV levels tended to be correlated with the probability of hemorrhage. The identification of a large number of unique FV-deficient pedigrees highlighted the screening for mutations in F5.