bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between metabolic obesity phenotypes and multiple myeloma hospitalization burden: A national retrospective study
Authors: Zhang Yue , Fan Xiude , Zhao Chunhui , Yuan Zinuo , Cheng Yiping , Wu Yafei , Han Junming , Yuan Zhongshang , Zhao Yuanfei , Lu Keke 
Published: February 2023

Background &amp; purposeObesity and metabolic disorders were associated with increased risk of MM, a disease characterized by high risk of relapsing and require frequent hospitalizations. In this study, we conducted a retrospective cohort study to explore the association of metabolic obesity phenotypes with the readmission risk of MM.Patients &amp; methodsWe analyzed 34,852 patients diagnosed with MM from the Nationwide Readmissions Database (NRD), a nationally representative database from US. Hospitalization diagnosis of patients were obtained using ICD-10 diagnosis codes. According to obesity and metabolic status, the population was divided into four phenotypes: metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). The patients with different phenotypes were observed for hospital readmission at days 30-day, 60-day, 90-day and 180-day. Multivariate cox regression model was used to estimate the relationship between obesity metabolic phenotypes and readmissions risk.ResultsThere were 5,400 (15.5%), 7,255 (22.4%), 8,025 (27.0%) and 7,839 (35.6%) unplanned readmissions within 30-day, 60-day, 90-day and 180-day follow-up, respectively. For 90-day and 180-day follow-up, compared with patients with the MHNO phenotype, those with metabolic unhealthy phenotypes MUNO (90-day: P = 0.004; 180-day: P = &lt; 0.001) and MUO (90-day: P = 0.049; 180-day: P = 0.004) showed higher risk of readmission, while patients with only obesity phenotypes MHO (90-day: P = 0.170; 180-day: P = 0.090) experienced no higher risk. However, similar associations were not observed for 30-day and 60-day. Further analysis in 90-day follow-up revealed that, readmission risk elevated with the increase of the combined factor numbers, with aHR of 1.068 (CI: 1.002-1.137, P = 0.043, with one metabolic risk factor), 1.109 (CI: 1.038-1.184, P = 0.002, with two metabolic risk factors) and 1.125 (95% CI: 1.04-1.216, P = 0.003, with three metabolic risk factors), respectively.ConclusionMetabolic disorders, rather than obesity, were independently associated with higher readmission risk in patients with MM, whereas the risk elevated with the increase of the number of combined metabolic factors. However, the effect of metabolic disorders on MM readmission seems to be time-dependent. For MM patient combined with metabolic disorders, more attention should be paid to advance directives to reduce readmission rate and hospitalization burden.
Metabolic syndrome and survival of patients with hepatocellular carcinoma: A meta-analysis
Authors: Fu Jia , Jiang Jinqiong , Liu Kanghan 
Published: February 2023

BackgroundMetabolic syndrome (MetS) has been related to a high incidence of hepatocellular carcinoma (HCC). However, the influence of MetS on survival of patients with HCC is still unclear. We performed a systematic review and meta-analysis to evaluate the association between MetS and survival of HCC patients.MethodsA search of PubMed, Embase, and Web of Science retrieved relevant cohort studies from the inception of the databases to October 16, 2022. Data collection, literature search, and statistical analysis were carried out independently by two authors. We pooled the results using a random-effects model that incorporates heterogeneity.ResultsIn the meta-analysis, 8080 patients with HCC were included from ten cohort studies, and 1166 patients (14.4%) had MetS. Eight studies included patients treated primarily with radical hepatectomy, one study with patients receiving sorafenib, and another study included patients who were treated with radical hepatectomy or non-surgical treatments. Pooled results showed that MetS was associated with poor overall survival (OS, risk ratio [RR]: 1.21, 95% confidence interval [CI]:1.08 to 1.37, p = 0.001; I2 = 32%) and progression-free survival (PFS, RR: 1.33, 95% CI: 1.18 to 1.49, p &lt; 0.001, I2 = 14%). Influencing analysis by excluding one study at a time showed consistent results (p all &lt; 0.05). Subgroup analyses showed similar results in studies with MetS diagnosed with the National Cholesterol Education Program Adult Treatment Panel III or International Diabetes Federal criteria, and in studies with mean follow-up durations &lt; or ≥ 3.5 years (p for subgroup difference all &gt; 0.05).ConclusionIn patients with HCC, MetS may be a risk factor of poor OS and PFS, particularly for those after radical hepatectomy.
Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study
Authors: Athikarisamy Sam Ebenezer , Lam Geoffrey C. , Cooper Matthew N. , Strunk Tobias 
Published: February 2023

AimRetinopathy of prematurity (ROP) is a biphasic vaso-proliferative disease that has the potential to cause blindness. In addition to prematurity and hyperoxia, perinatal infection and inflammation have been reported to play a critical role in the pathogenesis of ROP. The aim of this study was to assess the association between placental inflammation and the severity of ROP.MethodsA retrospective study of infants (&lt;30 weeks of gestational age) born at the King Edward Memorial Hospital, a tertiary perinatal center in Western Australia.ResultsA total of 878 infants were included in this study (ROP stage 0–2 = 829; 3 or more = 49). The presence of maternal chorioamnionitis appeared to show signs of an association with reduced odds of severe ROP: mild chorioamnionitis OR=0.43 (95% CI: 0.17, 1.05) and severe chorioamnionitis OR=0.68 (95% CI: 0.29, 1.60). A strong association was observed for oxygen supplementation at 36 weeks (OR: 5.16; p &lt; 0.001), exposure to postnatal steroids (OR: 6.65; p &lt; 0.001), and receipt of platelet transfusion (OR: 8.21; p &lt; 0.001).ConclusionMaternal chorioamnionitis or fetal chorioamnionitis was associated with reduced odds of severe ROP. A strong association was found in infants who needed oxygen supplementation at 36 weeks and those who required steroids or platelets in the postnatal period.
Why do pregnant women with fear of birth prefer vaginal birth? A qualitative study in China
Authors: Zeng Tieying , Yuan Mengmei , Wu Meiliyang , Chen Ye , Zhang Ke 
Published: February 2023

BackgroundFear of birth (FOB) is becoming increasingly recognized as a mental health issue that may endanger maternal and infant health and affects women’s subsequent fertility desires. It has also been shown to be related to the choice of delivery mode. Given the differences in healthcare systems and policies between countries, and the gaps in the exploration of women’s experience of fear of birth and its association with the delivery mode in the Chinese cultural context, this study thus attempt to understand Chinese women’s experience with fear of birth and their preferences for delivery mode through a qualitative study.MethodsA descriptive qualitative research was performed among twenty pregnant women from the obstetric outpatient of a tertiary hospital in China. Colaizzi’s method was used to analyze the participants’ data.ResultsWe proposed three themes and nine subthemes on the participants’ experience with fear of birth: (1) an invisible dilemma: trapped in lingering fear (fear of all sides, the untold loneliness, and ambivalence with mixed feelings); (2) an unexpected decision: choose to give birth naturally (initiative selection and passive acceptance); and (3) A strength to confront challenges head-on: move forward with fear (awaken of maternal spirit, hope in bloom, Chinese tolerance culture, and obstetric analgesia).ConclusionFear of birth is a complex emotion, accompanied by feelings of loneliness and ambivalence in addition to fear. We found that women with fear of birth in this study prefer vaginal birth, and it was revealed to be the result of a combined action of intrinsic and extrinsic factors.
What are the key drivers to promote continuance intention of undergraduates in online learning? A multi-perspective framework
Authors: Zhang Jintao , Zhang Mingbo , Liu Yanming , Zhang Liqin 
Published: February 2023

Introduction/AimThe purpose of this study is to investigate the key predictors of online learning system continuance intention using expectation-confirmation theory and information system success model as the theoretical framework.MethodsA total of 537 respondents participated in the questionnaire to measure their self-reported responses to eight constructs (perceived usefulness, interaction, confirmation, satisfaction, continuance intention, information quality, system quality, service quality). Convenience sampling was used to obtain participants in this study. Partial least square structural equation model is used for data analysis.ResultsThe results showed that all the hypotheses were validated except that there was no significant positive relationship between online learning interaction and student satisfaction. Meanwhile, the variance of the continuance intention of the online learning system reached 74.0%, falling within the moderate to substantial. In addition, the multi-group analysis of perceived usefulness, satisfaction and continuance intention showed that there was no significant gender difference in the above two relationships.DiscussionFinally, this study also puts forward the theoretical and practical implications of college students’ continuance intention of online learning system.
COVID-19 pandemic experiences of students from BAME and White ethnic groups pursuing higher education in the UK: A qualitative comparative exploration
Authors: Hitch Geeta , Zaman Shahaduz 
Published: February 2023

BackgroundThe new severe acute respiratory syndrome coronavirus 2, SARS-Cov2, more commonly known as COVID-19 continues to be an ongoing cause of one of the most disruptive pandemics worldwide. UK universities comprise students who come from different backgrounds and cultures and the majority returned home or lived alone during the lockdown. This qualitative study aimed to compare the experiences of students from Black, Asian, and Minority Ethnic (BAME) backgrounds and White British students.Materials and methodsAn in-depth interview was conducted with each of 35 students—18 from BAME and 17 from White backgrounds—in their homes on Zoom or Microsoft between November 2020 and May 2021. Interview transcripts were checked for accuracy and were analysed using N-Vivo coding software for themes. The pre-pandemic and pandemic experiences of students were collected in the form of a data, including perceptions of the COVID-19 virus, the physical environment in which students lived, and the effect on their general wellbeing, social interactions, online learning, teaching, and assessment.ResultsMental health issues were more prevalent among female students compared to males and this was more evident amongst BAME females who had returned to living at home, possibly due to lack of personal space. There was a reduction in personal hygiene in White females. There was an increase in the use of social media, particularly by BAME females. Students mostly disliked online learning and exams. Concerns were also raised about how universities communicated important information to the students.ConclusionBased on the recommendations of the WHO in relation to COVID-19, universities need to effectively manage the information they provide to students and build trust through risk communication and community engagement. One important area in this regard is addressing access to mental health services. The reasons why BAME females experience more mental health issues should be explored further.
Combining actigraphy and experience sampling to assess physical activity and sleep in patients with psychosis: A feasibility study
Authors: Pieters Lydia E. , Deenik Jeroen , de Vet Sabine , Delespaul Philippe , van Harten Peter N. 
Published: February 2023

BackgroundSleep disorders and reduced physical activity are common in patients with psychosis and can be related to health-related outcomes such as symptomatology and functioning. Mobile health technologies and wearable sensor methods enable continuous and simultaneous monitoring of physical activity, sleep, and symptoms in one’s day-to-day environment. Only a few studies have applied simultaneous assessment of these parameters. Therefore, we aimed to examine the feasibility of the simultaneous monitoring of physical activity, sleep, and symptoms and functioning in psychosis.MethodsThirty three outpatients diagnosed with a schizophrenia or other psychotic disorder used an actigraphy watch and experience sampling method (ESM) smartphone app for 7 consecutive days to monitor physical activity, sleep, symptoms, and functioning. Participants wore the actigraphy watch during day and night and completed multiple short questionnaires (eight daily, one morning, and one evening) on their phone. Hereafter they completed evaluation questionnaires.ResultsOf the 33 patients (25 male), 32 (97.0%) used the ESM and actigraphy during the instructed timeframe. ESM response was good: 64.0% for the daily, 90.6% for morning, and 82.6% for evening questionnaire(s). Participants were positive about the use of actigraphy and ESM.ConclusionThe combination of wrist-worn actigraphy and smartphone-based ESM is feasible and acceptable in outpatients with psychosis. These novel methods can help both clinical practice and future research to gain more valid insight into physical activity and sleep as biobehavioral markers linked to psychopathological symptoms and functioning in psychosis. This can be used to investigate relationships between these outcomes and thereby improve individualized treatment and prediction.
A literature review of sleep problems and neurodevelopment disorders
Authors: Al Lihabi Abeer 
Published: February 2023

IntroductionSleep is an incredibly complex process that goes beyond relaxing and body resting. Disturbance in sleep leads to several short-term and long-term consequences. Neurodevelopmental diseases such as “autism spectrum disorder” (ASDs), Attention-deficit hyperactivity disorder (ADHD), and intellectual disability commonly experience sleep disorders that affect their clinical presentation, daily function, and quality of life.DiscussionThe incidence of sleep problems in ASD patients ranges from 32 to 71.5%, especially insomnia, while an estimated 25–50% of people with ADHD report having sleep issues in clinical settings. The incidence of sleep issues is widespread in persons with intellectual disabilities, reaching up to 86%. This article is a literature review covering the neurodevelopmental disorder interaction with sleep disorder and different management.ConclusionDisorders of sleep are key concerns in children with neurodevelopmental disorders. In this group of patients, sleep disorders are common and tend to be chronic. Recognizing and diagnosis of sleep disorders will enhance their function, response to treatment, and quality of life.
Mapping study of papillary thyroid carcinoma in China: Predicting EQ-5D-5L utility values from FACT-H&N
Authors: Huang Deyu , Peng Jialing , Chen Na , Yang Qing , Jiang Longlin 
Published: February 2023

ObjectiveTo develop a mapping algorithm that can be used to predict EQ-5D-5L health utility scores from FACT-H&amp;N and obtain health utility parameters for Chinese patients with papillary thyroid carcinoma (PTC), which can be used for cost-utility analysis in health economic.MethodsA total of 1,050 patients with PTC from a tertiary hospital in China were included, and they completed FACT-H&amp;N and EQ-5D-5L. Four mapping algorithms of direct mapping functions were used to derive the models: Ordinary least squares (OLS), Tobit model (Tobit), Two-part model (TPM), and Beta mixture regression model (Beta). The goodness-of-fit of models was assessed by the mean absolute error (MAE), root mean square error (RMSE), Akaike information criteria (AIC), Bayesian information criteria (BIC), and absolute error (AE). A fivefold cross-validation method was used to test the stability of the models.ResultsThe mean utility value of the EQ-5D-5L was 0.870 ± 0.094. The mean EQ-VAS score was 76.5 ± 13.0. The Beta mixture regression model mapping FACT-H&amp;N to EQ-5D-5L achieved the best performance [fivefold cross-validation MAE = 0.04612, RMSE = 0.06829, AIC = −2480.538, BIC = −2381.137, AE &gt; 0.05 (%) = 32.48, AE &gt; 0.1 (%) = 8.95]. The independent variables in this model were Physical Well-Being (PWB), Emotional Well-Being (EWB), Head &amp; Neck Cancer Subscale (HNCS) scores and its square term and interaction term scores.ConclusionsThis study calculated the health utility score of Chinese patients with PTC. The reported algorithms can be used to map the FACT-H&amp;N into the EQ-5D-5L, which can be applied in the cost-utility related study of patients with PTC.
Nonlinear effects of pandemic uncertainty on depression, pandemic preventive behavior intentions, and positive life attitudes: Moderating effects of high and low uncertainty grouping
Authors: Liu Zeyu , Liu Yun , Li Ang , Zhu Tingshao 
Published: February 2023

BackgroundsCOVID-19 is difficult to end in a short time and people are still facing huge uncertainties. Since people's lives are gradually returning to normal, the sense of control and intolerance of uncertainty, which were mainly focused by past studies, are not specific to COVID-19 and will be more influenced by some factors unrelated to the pandemic. Therefore, they may be difficult to accurately reflect the individuals' perceptions of uncertainty. Besides, past research just after the outbreak mainly investigated people in high levels of uncertainty, we don't know the impact of uncertainties on individuals' psychological states when people gradually recovered their sense of control. To solve these problems, we proposed the concept of “pandemic uncertainty” and investigated its impact on people's daily lives.MethodsDuring October 20, 2021 to October 22, 2021, this study obtained data about uncertainty, depression, positive attitude, pandemic preventive behavior intentions, personality, and social support from 530 subjects using convenient sampling. The subjects were all college students from the Dalian University of Technology and Dalian Vocational and Technical College. According to the distribution of uncertainty, we divided the dataset into high and low groups. Subsequently, by using uncertainty as the independent variable, the grouping variable as the moderating variable, and other variables as the control variables, the moderating effects were analyzed for depression, positive attitude, and pandemic preventive behavior intentions, respectively.ResultsThe results showed that the grouping variable significantly moderate the influence of uncertainty on positive attitude and pandemic preventive behavior intentions but had no significant effect on depression. Simple slope analysis revealed that high grouping uncertainty significantly and positively predicted positive attitude and pandemic preventive behavior intentions, while low grouping effects were not significant.ConclusionThese results reveal a nonlinear effect of pandemic uncertainty on the pandemic preventive behavior intentions and positive life attitudes and enlighten us about the nonlinear relationship of psychological characteristics during a pandemic.
Tracing 33P-labelled organic phosphorus compounds in two soils: New insights into decomposition dynamics and direct use by microbes
Authors: Wasner Daniel , Prommer Judith , Zezula David , Mooshammer Maria , Hu Yuntao , Wanek Wolfgang 
Published: February 2023

IntroductionOrganic phosphorus (Po) compounds constitute an important pool in soil P cycling, but their decomposition dynamics are poorly understood. Further, it has never been directly tested whether low molecular weight Po compounds are taken up by soil microbes in an intact form, which reduces the dependence of their P acquisition on extracellular phosphatases.MethodsWe investigated the short-term fate (24 h) of five 33P-labelled Po compounds (teichoic acids, phospholipids, DNA, RNA and soluble organophosphates) and 33P-labelled inorganic P (Pi) in two soils.ResultsWe found indications that soil microbial breakdown of phosphodiesters was limited by the depolymerization step, and that direct microbial uptake of Po occurred to a substantial extent.DiscussionWe postulate a trade-off between direct Po uptake and complete extracellular Po mineralization. These findings have profound consequences for our understanding of microbial P cycling in soils.
Exploring innovation adoption behavior for sustainable development of Mediterranean tree crops
Authors: Timpanaro Giuseppe , Pecorino Biagio , Chinnici Gaetano , Bellia Claudio , Cammarata Mariarita , Cascone Giulio , Scuderi Alessandro 
Published: February 2023

IntroductionThe combination of knowledge, personal skills and company resources influences, all things being equal, such as the availability of new technologies, market conditions and other factors external to the company, farmers in their innovation choices. This study is an attempt to understand which psychological constructs influence the decision-making process of farmers specialized in typical Mediterranean crops with regard to innovation. Previous studies on the adoption of agricultural innovations have often considered socio economic characteristics and ignored the underlying motivational factors that influence the behavioral intention of farmers.MethodsThis study adopted three socio-psychological constructs, Attitude (ATT), Subjective Norm (SN), and Perceived Behavioral Control (PBC), derived from the Theory of Planned Behavior (TPB), and proposed three new constructs, Perceived Innovations Characteristics (PIC), Benefits (B), and Transferability (T), thus using an Extended Model of the Theory of Planned Behavior.ResultsThe outcome of the multiple regression revealed that farmers' intention (I) to adopt sustainable irrigation innovations is positively influenced by attitude (ATT), subjective norm (SN), and perceived innovation characteristics (PIC). This last construct had mediating effects on the indirect relationships between PBC, benefits (B), transferability (T), and intention (I).DiscussionThe results provide numerous insights, useful both for outlining the demand for innovation and for calibrating future policies aimed at the primary sector, especially on the sustainable management of irrigation resources. In particular, the analyses carried out highlight the importance of factors external to the company as key levers in shaping the demand for innovations.