bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the slope gradient effect and driving factors of construction land in urban agglomerations in the Upper Yellow River: A case study of the Lanzhou-Xining Urban Agglomerations
Authors: Zhang Hanxuan , Zhao Xiangjuan , Ren Jun , Li Chengying , Guo Jing , Hai Wenjing , Gao Yapei 
Published: January 2023

Abstract
Analyses of the scale and structural characteristics of construction lands serve as the basis for delineating urban development boundaries and optimizing the spatial pattern of territorial planning. Existing studies have focused mainly on the horizontal expansion of urban construction lands, while few comprehensive studies have explored the slope gradient effects of urban construction land, rural settlement land or other construction land in the horizontal-expansion dimension or vertical slope-spectrum dimension. Therefore, based on the Google Earth Engine (GEE) platform, in this paper, we use high-precision land use cover data, DEM data and socioeconomic data to construct the standard dominant comparative advantage index (NRCA) using the geological mapping analysis method and systematically analyze the horizontal scale, slope spectrum characteristics, gradient effects and driving factors of construction lands in the Lanzhou-Xining urban agglomeration (LXUA) from 1990 to 2020 at four scales: the urban agglomeration, provincial area, typical city and county (district) scales. The results of the study show that urban construction land, rural settlement land and other construction land in the LXUA show "linear", inverted "U" and "J" growth patterns, respectively. The areas of rural settlements in 9 counties (districts) are decreasing, and the number of counties (districts) with decreasing areas is increasing, while the areas of other construction land in most counties (districts) are increasing. The center of urban construction gravity continues to shift northwestward, and the standard deviation ellipse is becoming flatter; the center of gravity of rural settlement lands continues to shift southeastward. The center-of-gravity distribution and standard deviation elliptical characteristics of construction land at other scales also vary to different degrees. The scale and extent of the increase in urban construction land in the LXUA is gradually decreasing over time, and the number of rural settlement lands in 2000–2010 was as high as 34 counties (districts), while the number of counties (districts) with strong degrees of other increased construction land rose to 12 from 2010 to 2020. The relative hotspots of the three types of increasing construction land have gradually expanded spatially, with Lanzhou city and Xining city as the center, and the overall spatial characteristics are “more in the east and less in the west”. The population and GDP are the main factors influencing urban construction land increases, while rural settlements are influenced mainly by natural conditions, and accessibility is the key factor affecting other construction land.
Seismic risk of typical ageing petrochemical steel structure in harsh atmospheric conditions
Authors: Sarno Luigi Di 
Published: January 2023

Abstract
This paper addresses the evaluation of the effects of corrosion on the performance of ageing steel industrial infrastructures. A novel probabilistic risk assessment method is presented with respect to a case study of a real petrochemical structure located in an atmospheric environment with high severity of corrosion. The results of damage assessment derived from refined fragility analyses revealed that long-term corrosion mass reduction can increase the probability of damage to the structure by an average of 40%. Furthermore, the risk analysis demonstrated that the annual failure rate of the corroded structure is at most 2.80 times that of the uncorroded counterpart. The vulnerability analysis showed that the difference in annual repair costs between corroded and uncorroded cases gradually increased as the severity of ground motion raised. Moreover, the results of comprehensive and refined nonlinear analyses indicated that the corroded structure after 50 and 100 years can increase the likelihood of causing corrosion repair costs in the first year by about 40 and 60 times, respectively. The evaluation of the ratio of construction to maintenance and retrofitting was also carried out; it was based on innovative retrofitting measures with the use of Carbon Fibre Reinforced Polymers for steel structures. The findings illustrated in the present numerical study can help owners and insurance companies to predict more reliably maintenance and repair costs, thus they can provide an efficient roadmap for industrial asset management.
Chiral phonons probed by X rays
Authors: Staub Urs , Ueda Hiroki , Garcia-Fernandez Mirian , Agrestini S. , Romao Carl , Brink Jeroen van den , Spaldin Nicola , Zhou Ke-Jin 
Published: January 2023

Abstract
The concept of chirality is of great relevance in nature, from chiral molecules such as sugar to parity transformations in particle physics. In condensed matter physics, recent studies have demonstrated chiral fermions and their relevance in emergent phenomena closely related to topology [1-3]. The experimental verification of chiral phonons (bosons) remains challenging, however, despite their expected strong impact on fundamental physical properties [4-6]. Here we show experimental proof of chiral phonons using resonant inelastic X-ray scattering with circularly polarized X rays. Using the prototypical chiral material, quartz, we demonstrate that circularly polarized X rays, which are intrinsically chiral, couple to chiral phonons at specific positions in reciprocal space, allowing us to determine the chiral dispersion of the lattice modes. Our experimental proof of chiral phonons demonstrates a new degree of freedom in condensed matter that is both of fundamental importance and opens the door to exploration of novel emergent phenomena based on chiral bosons.
DHCR7 Expression Predicts Poor Outcomes and Mortality from Sepsis
Authors: Guirgis Faheem W. , Jacob Vinitha , Wu Dongyuan , Henson Morgan , Daly-Crews Kimberly , Hopson Charlotte , Black Lauren Page , DeVos Elizabeth L. , Sulaiman Dawoud , Labilloy Guillaume , Brusko Todd M. , Shavit Jordan A. , Bertrand Andrew , Feldhammer Matthew , Baskovich Brett , Graim Kiley , Datta Susmita , Reddy Srinivasa T. 
Published: January 2023

Abstract
Objective: Sepsis patients experience poor outcomes including chronic critical illness (CCI) or early death (within 14 days). We investigated lipid metabolic gene expression differences by outcome to discover therapeutic targets.
Design: Secondary analysis of samples from prospectively enrolled sepsis patients and a zebrafish sepsis model for drug discovery.
Setting: Emergency department or ICU at an urban teaching hospital.
Patients: Sepsis patients presenting within 24 hours.
Methods: Enrollment samples from sepsis patients were analyzed. Clinical data and cholesterol levels were recorded. Leukocytes were processed for RNA sequencing (RNA-seq) and reverse transcriptase polymerase chain reaction (RT-qPCR). A lipopolysaccharide (LPS) zebrafish sepsis model was used for confirmation of human transcriptomic findings and drug discovery.
Measurements and Main Results: There were 96 samples in the derivation (76 sepsis, 20 controls) and 52 in the validation cohort (sepsis only). The cholesterol metabolism gene 7-Dehydrocholesterol Reductase (DHCR7) was significantly upregulated in both derivation and validation cohorts in poor outcome sepsis compared to rapid recovery patients and in 90-day non-survivors (validation only) and validated using RT-qPCR analysis. Our zebrafish sepsis model showed upregulation of dhcr7 and several of the same lipid genes upregulated in poor outcome human sepsis (dhcr24, sqlea, cyp51, msmo1, ldlra) compared to controls. We then tested six lipid-based drugs in the zebrafish sepsis model. Of these, only the Dhcr7 inhibitor AY9944 completely rescued zebrafish from LPS death in a model with 100% lethality.
Conclusions: DHCR7, an important cholesterol metabolism gene, was upregulated in poor outcome sepsis patients warranting external validation. This pathway may serve as a potential therapeutic target to improve sepsis outcomes.
Changes in Soil organic carbon and total nitrogen following long-term grazing exclusion in Saral grasslands, Kurdistan (Iran)
Authors: Bandak Isa , Karami Parviz , Karaji Mahtab Gurgin , Dragovich Deirdre 
Published: January 2023

Abstract
Background and aims: Land use change favouring agriculture is considered a global threat as it interrupts ecosystem services of grasslands. However, exclosure from grazing has been widely known as effective in maintaining or even restoring grasslands. This study examined the impacts of long-term (45 years) exclosure, heavy grazing and rainfed wheat farming on soil organic carbon (SOC) and total nitrogen (TN) in the cold semi-arid grasslands of Saral Agricultural and Natural Resources Research Station, Kurdistan, Iran.
Methods: In this investigation, 90 soil samples were taken from 0-20 cm depth within an area of 0.5 hectare for each land use (exclosure, heavy grazing, wheat farming). Samples were collected in the four non-consecutive years of 2009, 2013, 2017 and 2021. The Walkley-Black and Kjeldahl methods were used to measure SOC and TN respectively.
Results: Results showed that value of SOC differed significantly among different land uses (P<0.01). In the studied years, SOC in the excluded site in 2021 had the highest level with 34,787 kg/ha, while the grazed site recorded the lowest SOC with 26,342 kg/ha in the same year. TN was also the highest at 0.130 percent in the excluded area in 2021, while TN was lower at 0.102 and 0.103 percent in the grazed and wheat-farming areas respectively in 2021.
Conclusion: This suggests that in grasslands with the same ecological conditions, managers can choose appropriate grazing intensity as an alternative to either heavy grazing or rainfed wheat farming, though more investigations on the efficiency of different grazing intensities are needed.
Aberrant Histone Modification of TNFAIP3, TLR4, TNIP2, miR-146a, and miR-155 in Major Depressive Disorder
Authors: Tseng Chu-Chiao , Wang Shao-Cheng , Yang Yi-Chien , Fu Hung-Chun , Chou Chen-Kai , Kang Hong-Yo , Hung Yi-Yung 
Published: January 2023

Abstract
Activated toll-like receptor (TLR) signaling has been well investigated in major depressive disorder (MDD). We previously reported that TNFAIP3, TLR4, TNIP2, miR-146a, and miR-155 play important roles in regulating the toll-like receptor 4 (TLR4) signaling pathway and may serve as novel targets in the pathogenesis of MDD. Recently, aberrant histone modification has been implicated in several psychiatric disorders, including schizophrenia and mood disorder; the most thoroughly studied modification is histone 3 lysine 4 tri-methylation (H3K4me3). In this work, we aimed to explore H3K4me3 differences in the promotors of genes encoding the abovementioned factors in patients with MDD, and whether they were altered after antidepressant treatment. A total of 28 MDD patients and 28 healthy controls were recruited. Peripheral blood mononuclear cells (PBMCs) were collected. The levels of H3K4me3 in the promoters of TNFAIP3, TLR4, TNIP2, miR-146a, and miR-155were measured through chromatin immunoprecipitation (ChIP) followed by DNA methylation assay. Analysis of covariance was used to evaluate between-group differences after adjusting for age, sex, BMI, and smoking. In comparison with healthy controls, patients with MDD showed significantly lower H3K4me3 levels in the promoters of TNFAIP3, TLR4, TNIP2, miR-146a, and miR-155 in PBMCs. These levels were not significantly altered after completion of a 4-week antidepressant treatment. To explore the association between depression severity and H3K4me3 levels, a multiple linear regression model was generated. The results revealed that levels of H3K4me3 in the TNIP2 promoters a negative correlation with the 17-item Hamilton Depression Rating Scale (HAND-17) score, whereas that of TLR4 had a positive correlation with this score. The present results suggest that decreased H3K4me3 levels in the promoters of the genes encoding TNFAIP3, TLR4, miR-146a, miR-155, andTNIP2 may be a mechanism underlying the mRNA expression dysregulation reported in MDD patients.
Flame Dynamics modelling using Artificial Thickened Models
Authors: Rathore Omer , Navarro-Martinez Salvador 
Published: January 2023

Abstract
Thickened flame models are prolific in the literature and offer an effective method of resolving flame dynamics on coarse LES meshes. The current state of the art relies heavily on the use of efficiency functions to compensate for impaired wrinkling of the thickened flame. However in practice these functions can involve parameters that are difficult to determine, perform poorly outside of certain ranges or require \emph{a posteriori} analysis to evaluate performance.
An alternative based on a generalised thickening is evaluated across a range of canonical configurations. The approach is demonstrated to perform well across a large range of thickening factors in capturing phenomena such as localised quenching and pinch off as well as generation of flame surface. Including good performance even in the case of large flame dynamics under acoustic forcing where the model has a clear advantage over DNS in achieving grid independence.
Finally the approach is unified into an Large Eddy Simulation/Adaptive Mesh Refinement framework and applied to a turbulent Bunsen flame.

The results show that even if the internal flame structure is poorly resolved on the original mesh, the global system behaviour is well predicted and compares favourably with other approaches.
Pseudo-Trilateral Adversarial Training for Domain Adaptive Traversability Prediction
Authors: Chen Zheng , Pushp Durgakant , Liu Lantao 
Published: January 2023

Abstract
Traversability prediction is a fundamental perception capability for autonomous navigation. Deep neural networks (DNNs) have been widely used to predict traversability during the last decade. The performance of DNNs is significantly boosted by exploiting a large amount of data. However, the diversity of data in different domains imposes significant gaps in the prediction performance. In this work, we make efforts to reduce the gaps by proposing a novel pseudo-trilateral adversarial model named CALI to perform unsupervised domain adaptation (UDA). Our aim is to transfer the perception model with high data efficiency, eliminate the prohibitively expensive data labeling, and improve the generalization capability during the adaptation from easy-to-access source domains to various challenging target domains. Existing UDA methods usually adopt a bilateral zero-sum game structure. We prove that our CALI model - a pseudo-trilateral game structure is advantageous over existing bilateral game structures. This proposed work bridges theoretical analyses and algorithm designs, leading to an efficient UDA model with easy and stable training. We show the superiorities of our proposed model over multiple baselines in several challenging domain adaptation setups. To further validate the effectiveness of our model, we then combine our perception model with a visual planner to build a navigation system and show the high reliability of our model in complex natural environments.
WITHDRAWN: Influence of Openings on Earthquake Performance of Confined Masonry Structures
Authors: Sheikh Uzair Ab Latif 
Published: January 2023

Abstract
The zone around the openings is the location of high stress concentration as a result of which tensile stress develops in the area around the openings in any structure whether RCC, unreinforced masonry or confined masonry. In case of confined masonry significant researches and experiments have shown that the size, location and shape of an opening have a significant effect over the behaviour of confined masonry wall although many codes do not consider this effect. This paper presents the effect of openings (windows) on earthquake resistant behaviour of confined masonry structure. Seismic analysis of considered four confined masonry structures is done to arrive at more accurate conclusions. Various output parameters compared include base shear, seismic weight of structures, time periods in both the directions i.e. x and y directions. It was concluded from the analysis results that window should be placed as far from the centre location of wall panel as possible otherwise, it affects the diagonal strut action of the masonry wall panel and hence reducing its seismic performance.
The Effect of Spinach on the dissolution of Clopidogrel tablets
Authors: Sadaqa Dana , Naseef Hani A. , Radwan Asma , Rabba Abdallah K. , Muqedi Ramzi H. M. 
Published: January 2023

Abstract
Background: Drug-food interaction is a serious issue that should be taken into consideration when administering drugs for chronic diseases and life-saving drugs such as anticoagulants. Alteration of the properties of gastric fluid such as pH and film precipitation on tablet had a significant impact on dissolution and release of the drug which may further affect its therapeutic effect.
Methods: In vitro disintegration and dissolution tests were done in HCl buffer and phosphate buffer with and without spinach extract in each media. High performance liquid chromatography (HPLC) analysis was performed to measure the drug release in all media. Disintegration was performed in simulated intestinal fluid and compared to disintegration of drug in 5% spinach without removal of leaves to study the effect of film precipitation on the penetration of fluid onto the tablet.
Results: Dissolution was reduced at increased concentrations of spinach extract. It was found that, an increased pH in HCl buffer whenever spinach extract concentration increased, as well as the reduced solubility of clopidogrel in the relatively high pH phosphate buffer, or it can be attributed to the possibility of formation of a new complex between metals in spinach extract and clopidogrel drug. Addition of spinach leaves to media resulted in reduced penetration of fluid onto the tablet and delayed disintegration was observed. In-vitro In-vivo correlation (IVIVC) was observed in HCl buffer with a value of R2 0.74.
Conclusion: Concomitant administration of spinach soup with clopidogrel tablets causes decreased plasma concentration of active pharmaceutical ingredient (API) which may lead to decreased therapeutic efficacy and increased risk of cardiovascular events.
Evaluation of the impact of Covid-19 on Internet searches for bariatric surgery in the United Kingdom
Authors: TELFAH Muwaffaq , Currie Andrew , Amr Bassem , Welbourn Richard 
Published: January 2023

Abstract
Introduction: The Covid-19 (Covid) pandemic has significantly decreased the provision of UK bariatric surgery. We hypothesised that Internet searches for bariatric surgery might have increased during Covid. This study evaluated the impact of Covid on Internet searches for bariatric surgery in the UK population.
Materials and Methods: A Google Trends data search using search topics: ‘gastric bypass surgery’, ’sleeve gastrectomy’, ’adjustable gastric band’ and ‘gastric balloon’ was performed. Relative search volume (RSV) indices were reported from March 2017 to March 2022. Mean RSV pre-Covid (March 2017-March 2020) and during Covid (March 2020-March 2022) were compared. ANOVA was performed to determine the impact of Covid on RSV.
Results: Pre-Covid, gastric bypass surgery was most searched, whilst during Covid, sleeve gastrectomy became most commonly searched. ANOVA analysis revealed a significant increase in searches during Covid for sleeve gastrectomy (20.4% pre-Covid v 47.2% during Covid; p<00.1), gastric bypass surgery (25.4% v 30.7%; p<0.001) and gastric balloon (8.4% v 12.0%; p<0.001) but not adjustable gastric band (38.7% v 37.8%; p=0.350)
Conclusion: During the pandemic there was a significant increase in Internet searches for bariatric surgery, likely reflecting increased public awareness of the health impact of obesity and surgical treatment options.
Reorganization and suppression of store-operated calcium entry in podocytes induced by diabetes type 2
Authors: Gusev Konstantin , Shalygin Alexey , Kolesnikov Dmitrii , Shuyskiy Leonid , Makeenok Sofia , Glushankova Lyubov , Sivak Konstantin , Yakovlev Kirill , Orshanskaya Yana , Wang Guanghui , Bakhtyukov Andrey , Derkach Kira , Shpakov Alexander , Kaznacheyeva Elena 
Published: January 2023

Abstract
Type 2 diabetes mellitus (DM2) is a widespread metabolic disorder that results in podocyte damage and diabetic nephropathy. Previous studies demonstrated that TRPC6 channels play a pivotal role in podocyte function and their dysregulation is associated with development of different kidney diseases including nephropathy. It was assumed that activation of TRPC6 channels leads directly to the Ca2+ influx into cells. Another Ca2+ influx pathway, a store-operated Ca2+ entry (SOCE) via ORAI channels, was also shown to be disturbed during the diabetes development. Here, using single channel patch clamp technique, we demonstrated that non-selective cationic TRPC6 channels are sensitive to the Ca2+ store depletion in human podocyte cell line Ab8/13 and in freshly isolated rat glomerular podocytes. Ca2+ imaging indicated the involvement of ORAI and sodium-calcium exchanger (NCX) in Ca2+ entry induced upon store depletion. Ca2+ inflow by NCX is a result of pronounced TRPC6-mediated Na+ influx leading moreover to the membrane depolarization and ORAI suppression. In rats fed a high-fat diet combined with a low-dose streptozotocin injection, which leads to DM2 development, we observed the reduction of SOCE in rat glomerular podocytes. This was accompanied by a reorganization of store-operated Ca2+ influx such that TRPC6 channels lost their sensitivity to Ca2+ store depletion and ORAI-mediated Ca2+ entry is suppressed in TRPC6-independent manner. Altogether our data provide new insights into the mechanism of SOCE organization in podocytes in the norm and in pathology, which should be taken into account in the pharmacological treatment of the early stages of diabetic nephropathy.
The Influence of Patient Safety Culture on Intent to Leave among Jordanian Nurses
Authors: Dmaidi Kawther , Shosha Ghada Abu , Oweidat Islam , Nashwan Abdulqadir J. 
Published: January 2023

Abstract
Background: Patient safety culture is getting more attention from healthcare organizations worldwide, and Jordan is no exception. Nurses' satisfaction and retention are paramount to providing safe and high-quality patient care.
Purpose: To investigate the relationship between patient safety culture and intent to leave among Jordanian nurses.
Methods: A descriptive cross-sectional design was used. A sample of 220 nurses was selected through convenience sampling from one governmental and one private hospital in Amman. The patient safety culture survey and anticipated turnover scale were used to collect data.
Results: The findings showed that nurses had 49.2% positive scores for patient safety. Teamwork (65.3%) and handoff and exchange of information (62% each) had the highest scores, while staffing and work pace (38.1%) and response to error (26.6%) had the lowest. Moreover, nurses had strong intentions to leave their jobs (M = 3.98). A moderately significant but not highly negative relationship between patient safety culture and intent to leave (r = -0.32, p = 0.015) existed.
Conclusions: There are opportunities to improve patient safety culture, satisfaction, and nurse retention in Jordanian hospitals by implementing several recommendations, such as ensuring better staffing patterns and increasing staff motivation by utilizing various available methods.