bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bright LanthanideIII Triboluminescence despite Low Photoluminescence, and Dual Triboluminescence and Mechano‐Responsive Photoluminescence
Authors: Hirai Yuichi , Van Baaren Stann , Ohmura Takahito , Nakanishi Takayuki , Takeda Takashi , Kitagawa Yuichi , Hasegawa Yasuchika , Métivier Rémi , Allain Clémence 
Published: February 2023

AbstractIn pursuit of a new family of mechanically responsive luminescent materials, it is aimed to differentiate triboluminescence (TL) from photoluminescence (PL). A β‐diketonate ligand with tert‐butyl groups (2,2,6,6‐tetramethylheptane‐3,5‐dionate: tmh) is selected to quench EuIII‐centered PL via ligand‐to‐metal charge transfer, whereas tmh provides efficient photosensitization of TbIII ions. Bright TL is observed from the EuIII and TbIII homodinuclear complexes despite the fact that their PL quantum yields differed by a factor of >50. Nanomechanical tests reveal the ductility of the crystals, suggesting they are ideal for accumulating deformation energy before breakage. Furthermore, a TL/PL color difference is observed for a TbIII/EuIII heterodinuclear complex, and grinding results in mechanochromic luminescence (MCL); this is the first example of a dual TL‐ and MCL‐active lanthanideIII coordination compound. The photophysical properties before, during, and after grinding are investigated and correlated with powder and single‐crystal crystallographic data.
Research Progress of Extracellular Vesicles Targeted Therapy
Authors: Chen Yuling , Hou Shike 
Published: February 2023

AbstractExtracellular vesicles (EVs), including exosomes, have inherent homing ability in damage repair and drug delivery. However, they have poor targeting and low enrichment efficiency and are easily internalized/cleared by monocyte phagocyte system. If the targeting ability of exosomes can be improved through a series of means, better use can be made of the advantages of exosome therapy and drug delivery. It is necessary to ensure a certain retention rate to study signal pathways and potential mechanisms, especially in flowing blood. This article mainly reviews the research progress of specific targeting based on exosomes, including intrinsic targeting, enhanced targeting, and drug delivery. Inherent targeting is mainly analyzed from different cell sources, and enhanced targeting is mainly from ligand modification and the application of nano materials to improve the targeting ability. To be successfully applied in clinical practice, many problems and challenges still need to be faced in exosome therapy. Herein, the latest knowledge of using EVs as a natural delivery system for disease treatment is summarized.
Influence of cover crops on soybean yield and partial returns as an alternative to double‐crop soybean in Arkansas
Authors: Kirkpatrick Drew , Roberts Trenton L. , Brye Kris , Ross Jeremy 
Published: February 2023

AbstractThe number of hectares dedicated to winter wheat (Triticum aestivum L.) in the southern United States has been trending downward for almost a decade, presenting an opportunity for producers to utilize alternatives in their soybean [Glycine max (L.) Merr.] rotations, such as winter cover crops. A study was established to compare the cover crops to traditional cropping systems by determining the effect each had on a successive soybean crop and to examine partial economic returns. Cropping systems implemented were winter fallow, winter wheat, and seven cover crop treatments, including cereal rye (Secale cereale L.), black‐seeded oat (Avena sativa L.), barley (Hordeum vulgare L.), Austrian winter pea (Pisum sativum L.), blue lupin (Lupinus angustifolius L.), Blend 1 (cereal rye, crimson clover [Trifolium incarnatum L.], seven‐top turnip [Brassica rapa L.]). and Blend 2 (black‐seeded oats and Austrian winter pea). The winter cropping system did not affect the soybean plant population (p = 0.32). Soybean grain yield varied among the different winter cropping systems (p < 0.01) with yields ranging from 3346 to 3906 kg ha−1. The soybean double‐crop system ($1383.02 ha−1) and soybean following winter cover crops ($1239–1380 ha−1) produced similar partial returns but both were greater than soybean following winter fallow ($1217.81 ha−1) (p < 0.01). Soybean yields and partial returns were the highest when following Blend 2. Results of this study showed that winter cover crops can provide an adequate alternative to both winter fallow and traditional winter wheat soybean double‐crop systems in the mid‐southern United States.
Effect of tillage and nitrogen fertility on growth, yield, and seed chemical composition of rainfed Brassica carinata
Authors: Seepaul Ramdeo , Kumar Shivendra , Sidhu Sudeep , Small Ian M. , George Sheeja , Douglas Maynard , Wright David L. 
Published: February 2023

AbstractThe combination of subsoil compaction and injudicious usage of nitrogenous fertilizers are key factors that may lower crop yields, especially in soils with a shallow hardpan. Therefore, the objective of this study was to determine the effects of tillage and N application on carinata productivity in rainfed conditions. A 3‐year field study was conducted at the North Florida Research and Education Center, Quincy, FL, USA. Treatments were four rates of N (0, 45, 90, and 135 kg N ha−1) and three tillage methods (disking, chiseling, and no‐tillage). Maximum cone index measurements for no‐tillage occurred at 15 cm but at 20 cm soil depth for both chisel and disk tillage. A hardpan at 15 cm restricted taproot growth but promoted lateral root growth. Subsoiling and N application improved carinata growth relative to no‐tillage. Seed yield response to N application rate depended on the tillage method. The agronomic maximum seed yield occurred at 134, 128, and 125 kg N ha−1 for chisel, disk, and no‐tilled systems. Nitrogen agronomic efficiency was greatest at 45 kg N ha−1 for the chisel method and 95 kg N ha−1 for disk and no‐tillage. Tillage has a greater potential to increase yields even at relatively low N levels. When tilled, carinata produces 8%–17% greater seed yield at 45 kg N ha−1 than no‐tilled carinata grown with 135 kg N ha−1. These results indicate that tilling the subsoil and applying 90–135 kg N ha−1 are required for carinata production in soils with a hardpan.
Annual report on National Clinical Database 2020 for gastroenterological surgery in Japan
Authors: Kajiwara Yoshiki , Takahashi Arata , Ueno Hideki , Kakeji Yoshihiro , Hasegawa Hiroshi , Eguchi Susumu , Goi Takanori , Saiura Akio , Sasaki Akira , Takiguchi Shuji , Takeuchi Hiroya , Tanaka Chie , Hashimoto Masaji , Hiki Naoki , Horiguchi Akihiko , Matsuda Satoru , Mizushima Tsunekazu , Marubashi Shigeru , Gotoh Mitsukazu , Konno Hiroyuki , Yamamoto Hiroyuki , Miyata Hiroaki , Seto Yasuyuki , Kitagawa Yuko ,   The National Clinical Database
Published: February 2023

AbstractAimThe National Clinical Database (NCD) of Japan is a nationwide data entry system for surgery, and it marked its 10th anniversary in 2020. The aim was to present the 2020 annual report of gastroenterological surgery of the NCD.MethodsThe data of the surgical procedures stipulated by the training curriculum for board‐certified surgeons of the Japanese Society of Gastroenterological Surgery in the NCD from 2011 to 2020 were summarized.ResultsIn total, 5 622 845 cases, including 593 088 cases in 2020, were extracted from the NCD. The total number of gastroenterological surgeries increased gradually in these 10 years, except for the year 2020 due to the COVID‐19 pandemic. The annual number of surgeries of each organ, except the pancreas and liver, decreased by 0.4%–13.1% in 2020 compared to 2019. The surgical patients were consistently aging, with more than 20% of all gastroenterological surgeries in 2020 involving patients aged 80 years or older. The participation of board‐certified surgeons increased for each organ (75.9%–95.7% in 2020). The rates of endoscopic surgery also increased constantly. Although the incidences of postoperative complications of each organ increased by 0.7%–7.9% in these 10 years, postoperative mortality rates decreased by 0.2%–1.5%.ConclusionsWe present here the short‐term outcomes of each gastroenterological operative procedure in 2020. This review of the 10‐years of NCD data of gastroenterological surgery revealed a consistent increase of the number of surgeries (except for in 2020), especially endoscopic procedures, and aging of the Japanese population. The good safety of Japanese gastroenterological surgeries was also indicated.
Fewer chromosomes, more co‐occurring species within plant lineages: A likely effect of local survival and colonization
Authors: Bartish Igor V. , Bonnefoi Salomé , Aïnouche Abdelkader , Bruelheide Helge , Bartish Mark , Prinzing Andreas 
Published: February 2023

AbstractPremisePlant lineages differ markedly in species richness globally, regionally, and locally. Differences in whole‐genome characteristics (WGCs) such as monoploid chromosome number, genome size, and ploidy level may explain differences in global species richness through speciation or global extinction. However, it is unknown whether WGCs drive species richness within lineages also in a recent, postglacial regional flora or in local plant communities through local extinction or colonization and regional species turnover.MethodsWe tested for relationships between WGCs and richness of angiosperm families across the Netherlands/Germany/Czechia as a region, and within 193,449 local vegetation plots.ResultsFamilies that are species‐rich across the region have lower ploidy levels and small monoploid chromosomes numbers or both (interaction terms), but the relationships disappear after accounting for continental and local richness of families. Families that are species‐rich within occupied localities have small numbers of polyploidy and monoploid chromosome numbers or both, independent of their own regional richness and the local richness of all other locally co‐occurring species in the plots. Relationships between WGCs and family species‐richness persisted after accounting for niche characteristics and life histories.ConclusionsFamilies that have few chromosomes, either monoploid or holoploid, succeed in maintaining many species in local communities and across a continent and, as indirect consequence of both, across a region. We suggest evolutionary mechanisms to explain how small chromosome numbers and ploidy levels might decrease rates of local extinction and increase rates of colonization. The genome of a macroevolutionary lineage may ultimately control whether its species can ecologically coexist.
Evaluating niche changes during invasion with seasonal models in Capsella bursa‐pastoris
Authors: Wilson Brown Maya K. , Josephs Emily B. 
Published: February 2023

AbstractPremiseResearchers often use ecological niche models to predict where species might establish and persist under future or novel climate conditions. However, these predictive methods assume species have stable niches across time and space. Furthermore, ignoring the time of occurrence data can obscure important information about species reproduction and ultimately fitness. Here, we assess compare ecological niche models generated from full‐year averages to seasonal models.MethodsIn this study, we generate full‐year and monthly ecological niche models for Capsella bursa‐pastoris in Europe and North America to see if we can detect changes in the seasonal niche of the species after long‐distance dispersal.ResultsWe find full‐year ecological niche models have low transferability across continents and there are continental differences in the climate conditions that influence the distribution of C. bursa‐pastoris. Monthly models have greater predictive accuracy than full‐year models in cooler seasons, but no monthly models can predict North American summer occurrences very well.ConclusionsThe relative predictive ability of European monthly models compared to North American monthly models suggests a change in the seasonal timing between the native range to the non‐native range. These results highlight the utility of ecological niche models at finer temporal scales in predicting species distributions and unmasking subtle patterns of evolution.
Prolidase deficiency: A novel PEPD missense variant in exon 2
Authors: Ido Firas , Tessier Steven , Yoder Nicole , Ramzy Joseph , Longo Santo 
Published: February 2023

AbstractProlidase deficiency is an autosomal recessive disease that causes impaired collagen degradation. Altered collagen homeostasis results in the intracellular accumulation of imidodipeptides, which contain proline and hydroxyproline. The many clinical manifestations of prolidase deficiency include dysmorphic facial features, skeletal deformities, hepatosplenomegaly, necrotizing skin ulcers, and recurrent infections. Current clinical knowledge of this genetic disease relies upon few case reports due to its extreme rarity. Diagnosis is dependent on the detection of a pathologic gene variant. Additional diagnostic confirmation may be provided by urine amino acid quantification or reduced in vitro prolidase activity. We present a case of prolidase deficiency caused by a novel variant manifested by skeletal malformations and lifelong multisystemic infections. Genetic testing revealed a homozygous missense variant in the PEPD gene at nucleotide position 200, whereby adenine was replaced by guanine (c.200A > G). The corresponding amino acid change replaced glutamine with arginine at codon 67 (p.Gln67Arg). After boiling the urine sample for hydrolysis, quantitative urine amino acids demonstrated a markedly elevated proline level, confirming the diagnosis. We also provide a discussion of the pathophysiology, clinical manifestations, diagnostic testing, and clinical management of this disease.
4‐Chloro‐2‐azaadamantane N‐Oxyl (4‐Cl‐AZADO): A Readily Preparable Organocatalyst for NOx Co‐catalyzed Aerobic Alcohol Oxidation
Authors: Nagasawa Shota , Sasano Yusuke , Iwabuchi Yoshiharu 
Published: February 2023

AbstractConcise synthesis and structure‐activity relationships study of 4‐substituted 2‐azaadamantane N‐oxyls reveals that 4‐chloro‐2‐azaadamantane N‐oxyl (4‐Cl‐AZADO) is an efficient organocatalyst toward the aerobic oxidation of alcohols in the presence of NOx as a co‐catalyst. The organocatalyst was easily synthesized from 2‐adamantanone in five steps, and it showed high activity compared with many previously reported nitroxyl radical catalysts.
Biopsychosocial frailty and mild cognitive impairment subtypes: Findings from the Italian project on the epidemiology of Alzheimer's disease (IPREA)
Authors: Solfrizzi Vincenzo , Scafato Emanuele , Custodero Carlo , Piazzolla Giuseppina , Capogna Lavinia , Procaccio Annagrazia , Gandin Claudia , Galluzzo Lucia , Ghirini Silvia , Matone Alice , Dibello Vittorio , Sardone Rodolfo , Daniele Antonio , Lozupone Madia , Panza Francesco ,   IPREA Working Group
Published: February 2023

AbstractIntroductionFrailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial phenotypes. We operationalized a biopsychosocial frailty construct, estimating its association with mild cognitive impairment (MCI) and its subtypes.MethodsIn 1980, older individuals from the population‐based Italian PRoject on the Epidemiology of Alzheimer's disease (IPREA), we investigated cross‐sectional associations among biopsychosocial frailty, MCI, and its subtypes.ResultsParticipants with biopsychosocial frailty showed an increased odds ratio (OR) of MCI [OR: 4.36; 95% confidence interval (CI): 2.60‐7.29; Fisher's exact p < 0.01], particularly for nonamnestic MCI single domain (naMCI‐SD, OR:3.28; 95% CI: 1.35‐7.97; Fisher's exact p = 0.02) and for nonamnestic MCI multiple domain (naMCI‐MD, OR:6.92; 95% CI: 3.37‐14.21; Fisher's exact p < 0.01). No statistically significant associations between amnestic MCI single or multiple domain and biopsychosocial frailty were observed.DiscussionIn a large, older Italian cohort, a biopsychosocial frailty phenotype was associated with MCI, in particular, could be associated with some of its subtypes, that is, naMCI‐SD, and naMCI‐MD.
Directed Evolution of an Iron(II)‐ and α‐Ketoglutarate‐Dependent Dioxygenase for Site‐Selective Azidation of Unactivated Aliphatic C−H Bonds**
Authors: Gomez Christian A. , Mondal Dibyendu , Du Qian , Chan Natalie , Lewis Jared C. 
Published: February 2023

AbstractFeII‐ and α‐ketoglutarate‐dependent halogenases and oxygenases can catalyze site‐selective functionalization of C−H bonds via a variety of C−X bond forming reactions, but achieving high chemoselectivity for functionalization using non‐native functional groups remains rare. The current study shows that directed evolution can be used to engineer variants of the dioxygenase SadX that address this challenge. Site‐selective azidation of succinylated amino acids and a succinylated amine was achieved as a result of mutations throughout the SadX structure. The installed azide group was reduced to a primary amine, and the succinyl group required for azidation was enzymatically cleaved to provide the corresponding amine. These results provide a promising starting point for evolving additional SadX variants with activity on structurally distinct substrates and for enabling enzymatic C−H functionalization with other non‐native functional groups.
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference**
Authors: El Bakali Jamal , Blaszczyk Michal , Evans Joanna C. , Boland Jennifer A. , McCarthy William J. , Fathoni Imam , Dias Marcio V. B. , Johnson Eachan O. , Coyne Anthony G. , Mizrahi Valerie , Blundell Tom L. , Abell Chris , Spry Christina 
Published: February 2023

AbstractThe coenzyme A (CoA) biosynthesis pathway has attracted attention as a potential target for much‐needed novel antimicrobial drugs, including for the treatment of tuberculosis (TB), the lethal disease caused by Mycobacterium tuberculosis (Mtb). Seeking to identify inhibitors of Mtb phosphopantetheine adenylyltransferase (MtbPPAT), the enzyme that catalyses the penultimate step in CoA biosynthesis, we performed a fragment screen. In doing so, we discovered three series of fragments that occupy distinct regions of the MtbPPAT active site, presenting a unique opportunity for fragment linking. Here we show how, guided by X‐ray crystal structures, we could link weakly‐binding fragments to produce an active site binder with a KD <20 μM and on‐target anti‐Mtb activity, as demonstrated using CRISPR interference. This study represents a big step toward validating MtbPPAT as a potential drug target and designing a MtbPPAT‐targeting anti‐TB drug.
Periodic and event‐based impulse control for linear stochastic systems with multiplicative noise
Authors: Wang Bingchang , Wang Chao 
Published: February 2023

SummaryThis paper studies the performance comparison of periodic and event‐based sampling for a class of linear stochastic systems with multiplicative noise, where the impulse control is adopted. By solving boundary value problems, we obtain the analytic expressions of the mean sampling time and the average state variance under the event‐based sampling. It is shown that the event‐based impulse control has substantially smaller average state variance than the periodic control under the same sampling frequency. Particularly, for the integrator case, the performance ratio of the two sampling methods is given explicitly. By simulation, it is demonstrated that the advantage of event‐based sampling over periodic sampling is most obvious for unstable systems, followed by critical stable systems, and least obvious for stable systems.
Anti‐bias training and perceived force climate: Links with prejudiced attitudes in United Kingdom policing
Authors: Legate Nicole , Weinstein Netta , Graham Les , Plater Marisa 
Published: February 2023

AbstractAnti‐bias training has been viewed as the solution to prejudice in organizations, yet the evidence is mixed in real‐world settings. Some point to the broader organizational climate that training takes place in as critical, and herein we investigate one aspect: communicating about bias in autonomy‐supportive (i.e., non‐shaming) ways. Using the 2019 National Well‐Being and Inclusion Survey of United Kingdom police officers and staff (n = 34,529 in 43 forces), we tested links of participating in anti‐bias training, perceived autonomy‐supportive communication, and their interaction on prejudiced attitudes. Results revealed a negligible effect (R2 = 0.001) of participating in anti‐bias training but a moderate effect (R2 = 0.05) of perceiving autonomy‐supportive communication predicting lower prejudice. Their interaction was significant but negligible (R2 = 0.001): participating in anti‐bias training predicted lower prejudice when perceiving autonomy‐supportive communication; there was no link between training and attitudes without autonomy‐supportive communication. Implications for improving the effectiveness of anti‐bias training in applied settings and research are discussed.
The Opportunities and Challenges in Single‐Atom Catalysis
Authors: Zhou Yang , Jiang Yan , Ji Yuxia , Lang Rui , Fang Yanxiong , Wu Chuan‐De 
Published: February 2023

AbstractThe catalytic approaches fulfilled by the singly dispersed metal atoms anchoring on the solid materials were categorized as single‐atom catalysis. In this perspective, after briefly introducing the history in this research field, we compare the differences between single‐atom catalyst and several terms indicating some heterogeneous highly dispersed metal catalysts. Single‐atom catalysts could provide the simplified models in exploring the catalytically active structures, and a new era of designing catalysts at the atomic scale is thus opened. In this context, single‐atom catalysis may be regarded as a bridge to combine the homogeneous and heterogeneous catalysis. Moreover, the materials containing isolated metal centers also provide great opportunities in many other applications, such as medicinal treatment, selective separation of gas molecule, and quantum devices. At last, challenges to the single‐atom catalysis are discussed.
MOF‐Derived Materials Enabled Lithiophilic 3D Hosts for Lithium Metal Anode — A Review
Authors: Wei Tao , Lu Jiahao , Wang Mengting , Sun Cheng , Zhang Qi , Wang Sijia , Zhou Yanyan , Chen Daifen , Lan Ya‐Qian 
Published: February 2023

Comprehensive SummaryThis work systematically reviews recent progresses in the applications of MOF‐derived materials modified 3D porous conductive framework as hosts for uniform lithium deposition in LMBs. A series of commonly used lithiophilic materials and several kinds of representative MOF‐derivation‐modified 3D hosts as lithium metal anode (LMA) are presented. Finally, the challenges and future development of employing MOF‐derived materials to modify the 3D porous conductive framework for LMA are included.