bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesenchymal stromal/stem cells and their extracellular vesicles in liver diseases: insights on their immunomodulatory roles and clinical applications
Authors: Huai Qian , Zhu Cheng , Zhang Xu , Dai Hanren , Li Xiaolei , Wang Hua 
Published: September 2023

AbstractLiver disease is a leading cause of mortality and morbidity that is rising globally. Liver dysfunctions are classified into acute and chronic diseases. Various insults, including viral infections, alcohol or drug abuse, and metabolic overload, may cause chronic inflammation and fibrosis, leading to irreversible liver dysfunction. Up to now, liver transplantation could be the last resort for patients with end-stage liver disease. However, liver transplantation still faces unavoidable difficulties. Mesenchymal stromal/stem cells (MSCs) with their broad ranging anti-inflammatory and immunomodulatory properties can be effectively used for treating liver diseases but without the limitation that are associated with liver transplantation. In this review, we summarize and discuss recent advances in the characteristics of MSCs and the potential action mechanisms of MSCs-based cell therapies for liver diseases. We also draw attention to strategies to potentiate the therapeutic properties of MSCs through pre-treatments or gene modifications. Finally, we discuss progress toward clinical application of MSCs or their extracellular vesicles in liver diseases.
The Effect of Superplasticizers on Eco-friendly Low-Energy One-Part Alkali-Activated Slag
Authors: Refaie M. , Mohsen Alaa , Nasr El-Sayed A. R. , Kohail Mohamed 
Published: September 2023

AbstractOne-part alkali-activated materials (OP-AAM) have become a promising binder with low carbon and energy requirements associated with superior mechanical and durability characteristics. This study aims to employ commercial superplasticizers (naphthalene-based “Nb-SP” and polycarboxylate-based “PCb-SP”), as well as laboratory-prepared one (phenol–formaldehyde sulfanilate “PFS-SP”) in enhancing the properties of OP-AAM. The main problem of superplasticizers (SPs) in the AAM is their hydrolysis in the alkaline activator (NaOH) used in the activation reactions. Therefore, the thermo-chemical treatment process was utilized to mitigate the high activator alkalinity by impeding the NaOH in the aluminosilicate precursor matrix. The OP-AAM was fabricated from thermo-chemical treatment powder (TCT-P) resulting from sintering blast furnace slag (GGBFS) with 10 wt% NaOH at 300 and 500 °C. The XRD-pattern showed that NaOH was impeded in the GGBFS via sodium aluminum silicate phase formation after sintering at 500 °C. The results showed that the admixed OP-AAM prepared from TCT-P at 500 °C greatly enhanced the workability and mechanical properties. The PFS-SP proved its efficiency in improving the properties of OP-AAM prepared TCT-P at 300 and 500 °C, referring to its high stability in an alkaline medium. While PCb-SP reinforced the properties of OP-AAM prepared from TCT-P at 500 °C only, proving that PCb-SP promotes high capability in TCT-P-500 as well as in Portland cement.
Integrated impact assessment of climate change and hydropower operation on streamflow and inundation in the lower Mekong Basin
Authors: Ly Steven , Sayama Takahiro , Try Sophal 
Published: September 2023

AbstractWater resources are key to economic development of the Mekong River Basin, but are threatened by climate change and affected by hydropower development. Knowledge of these drivers’ integrated impact on future hydrological alterations is limited, especially with respect to flood inundation in the lower basin. This study assesses streamflow and flood extent alterations by reservoir operations and climate change using the latest climate projections. A distributed hydrologic model is used to generate discharge and flood extent. Our findings indicate substantial changes in seasonal and annual peak discharge due to reservoir operations. Under the future hydropower scenario, the discharge at Kratie will change by + 28% ( − 10%) during the dry (wet) season. While the effects of hydropower operations vary by season, climate change tends to increase river discharge overall. Under the high-emission scenario, the wet seasonal flow at Kratie will increase by + 7% in the near-future (2026–2050), but change by -5% under integrated impact of climate change and reservoir operations. In the far-future, the wet seasonal flow at Kratie under climate change only (integrated impact) will increase by + 33% (+ 19%). Although climate change is the dominant driver of flow alterations, hydropower development is critical for reducing discharge and flood magnitude. Nonparametric statistical testing shows significant changes in the inundated area by up to + 37% during the projected periods.
World-first report of low anterior resection for rectal cancer with the hinotori™ Surgical Robot System: a case report
Authors: Miura Ryo , Okuya Koichi , Akizuki Emi , Miyo Masaaki , Noda Ai , Ishii Masayuki , Ichihara Momoko , Korai Takahiro , Toyota Maho , Ito Tatsuya , Ogawa Tadashi , Kimura Akina , Takemasa Ichiro 
Published: September 2023

Abstract
Background
The hinotori™ Surgical Robot System was approved for use in colorectal cancer surgery in Japan in 2022. This robot has advantages, such as an operation arm with eight axes, an adjustable arm base, and a flexible three-dimensional viewer, and is expected to be utilized in rectal cancer surgery. Herein, we report the world's first surgery for rectal cancer using the hinotori™ Surgical Robot System.

Case presentation
A 71-year-old woman presented to our hospital with bloody stools. A colonoscopy revealed type 2 advanced cancer in the rectum, and a histological examination exposed a well-differentiated adenocarcinoma. Abdominal enhanced computed tomography divulged rectal wall thickening without significant swelling of the lymph nodes or distant metastasis. Pelvic magnetic resonance imaging showed tumor invasion beyond the intrinsic rectal muscle layer. The patient was diagnosed with cStage IIa (cT3N0M0) rectal cancer and underwent low anterior resection using the hinotori™ Surgical Robot System. Based on an adequate simulation, surgery was safely performed with appropriate port placement and arm base-angle adjustment. The operating time was 262 min, with a cockpit time of 134 min. Subsequently, the patient was discharged 10 days postoperatively without complications. The pathological diagnosis was pStage IIA (cT3N0M0) and the circumferential resection margin was 6 mm.

Conclusions
We report the first case of low anterior resection for rectal cancer using the hinotori™ Surgical Robot System, in which a safe and appropriate oncological surgery was performed.
Numerical study on the combustion process in a gas turbine combustor with different reference velocities
Authors: Gong Cheng , Zhao Shufan , Chen Weiqiang , Li Wenyu , Zhou Yu , Qiu Ming 
Published: September 2023

AbstractThe mixing and combustion processes under different reference velocities in a gas turbine combustor were numerically investigated using the Flamelet Generated Manifold (FGM) model based on the Reynolds Averaged Navier–Stokes (RANS) method. The flow and combustion fields show strong self-similarity except on the slow auto-ignition in the mixing layer between fuel-rich product and fresh air upstream of the flame stabilization position. The time-scale analysis was carried out to understand the combustion modes inside the combustor. In general, the residence time of the fuel-mixture is much longer than both the chemical time scale and the mixing time scale. Thus, the combustion properties in each sub-zone were dominated by the mean flow structures. Furthermore, the combustion process exhibits a mixing-controlled feature in total. However, partially premixed combustion still appears on the flame base. Most of the fuel was found to be oxidized in the primary zone and the intermediate zone; however, the slow oxidization reactions also play a non-negligible role on the whole combustion process. Finally, a sketch map on the space of mixture fraction and combustion efficiency was proposed to understand the mixing and oxidization experiences of the fuel mixture.
Managing diabetes in the psychiatric in-patient setting: knowledge, attitudes and skills of healthcare professionals
Authors: Goff Zoe , Sharma Vishal , Varvari Ioana 
Published: September 2023

Aims and methodThere is currently a lack of monitoring and standardisation of diabetes care in the National Health Service (NHS) psychiatric in-patient setting. We surveyed healthcare professionals in psychiatric in-patient units across England to understand current diabetes care. A 13-item questionnaire was piloted via think-aloud interviews. The survey was completed by healthcare professionals across 19 wards in 11 NHS mental health trusts. Results were analysed via descriptive statistics and thematic analysis.ResultsOf 150 respondents, 98% agreed that addressing physical health needs was an important part of the mental health team's role; 68% agreed that they had adequate skills and knowledge to manage diabetes safely. Thematic analysis identified themes relating to individual, organisational and patient-level factors.Clinical implicationsPsychiatric admission could be used opportunistically to improve the healthcare disparities for people with comorbid diabetes and severe mental illness. This national survey highlights areas that need to be addressed to optimise diabetes care in this setting.
A complementary approach to measure construct validity of WHO QOL BREF in Indian multidrug-resistant tuberculosis (MDR-TB) patients through psychometric property and factor analysis
Authors: Sharma Shweta , Kokane Arun M. , Krishna Subba N. , Joshi Ankur 
Published: September 2023

Background: Multidrug-resistant tuberculosis (MDR TB) affects the physical, psychosocial and inter-relationship structure and thus quality of life (QoL) of an individual. WHO QOL BREF is presumed to capture the QoL construct. This study investigates the diagnostic accuracy and construct of WHO QOL BREF from a psychometric perspective and complements and converges findings through classical test theory. Methods: The instrument validity study was conducted in a district of Central India amongst the microbiologically confirmed MDR TB cohort of year 2017 (n=98). We calculated global and domain-specific Cronbach alpha and Inter-domain Pearson correlations. The dichotomized items were fitted through Rasch model for item endorsement, response pattern and for variation inconsistencies. Item Characteristic Curves and person item maps were also plotted. We performed DIF (Differential Item Functioning) to check the effect of subgroups on underlying traits. This was complimented with an Exploratory Factor Analysis (EFA) using oblique ProMax rotation. The optimum number of factors were identified by Scree plot and parallel analysis approach and the emerging factor structure was compared with the result obtained through the Rasch model. Results: The global Cronbach’s alpha was 0.94 (95% CI 0.92-0.96). Social relationship domain had poor correlations with all three domains (r=0.42, r=0.41 r=0.58), higher beta values and less discrimination. DIF showed a differential response by gender. There was a visual clustering and a non-uniform distribution of items across the perceived QoL. A 3-factor model emerged through EFA and was reframed on the notion of self-concept. Items related to pain, medical aid had significant misfit and weak factor loading while items of sexual activity and social support had relatively poor performance in Infit, Wald, DIF on factor loading parameters. Conclusions: The study indicates the possible deviation of scale from theorized dimensional construct in Indian MDR TB context more with the items of the social relationship domain.
Supplementation of creatine and its role in brain function
Authors: Abod Leila , Ilnicka Natalia , Matyja Daria , Sadlik Maria , Zuziak Patrycja 
Published: September 2023

Introduction and aim. In recent years growing awareness of the society regarding healthy lifestyle leads to increased interest in regular physical activity and usage of dietary supplements. Creatine supplementation is often used among athletes to improve muscle mass, performance and recovery. The aim of this paper is to present the effects of creatine supplementation as well as its function in the body, forms and ways of intake, and potential benefits of its use.
Material and methods. A review of the available literature was performed by searching the PubMed and GoogleScholar databases using the following keywords: creatine, creatine supplementation, sports nutrition, brain function
Analysis of literature. Creatine is one of the most popular supplements recommended for athletes. It catalyzes transfer of phosphate groups into high energy compounds contributing in energy transportation and cellular energy buffering for cells and tissues with high energy demands. Its supplementation improves exercise performance, increases muscle mass and enhances recovery after training. In addition, there are indications that creatine shows promise in reducing symptoms associated with concussion, mild traumatic brain injury, and depression.
Conclusion. Creatine supplementation is used in sport mainly to improve exercise performance and muscle gain, however, it also plays an important role in brain function. In future it may be used in reducing symptoms associated with concussion, mild traumatic brain injury and depression.
Lefamulin - a recently developed antibiotic for treatment of community-acquired bacterial pneumonia (CABP)
Authors: Abod Leila , Ilnicka Natalia , Matyja Daria , Sadlik Maria , Zuziak Patrycja 
Published: September 2023

Introduction and aim. Nowadays, the increasing resistance of bacteria is a concerning and challenging issue in terms of effective treatment of bacterial infections. The amount of available antibiotics has been quite constant for many years. The search for substances alternative to older classes of drugs, among which resistance is growing, has been ongoing for years. One of the newly introduced available alternatives is lefamulin. The aim of this paper is to present the potential benefits of its use in comunity-acquired bacterial pneumonia (CABP).
Material and methods. A review of the available literature was performed by searching the PubMed and GoogleScholar databases using the following key words: lefamulin; BC3781; pleuromutilin; CABP; community acquired pneumonia.
Analysis of literature. Lefamulin is a bacteriostatic antibiotic from the group of pleuromutilins, which has a unique mechanism of action consisting in binding to the bacterial 50S ribosomal subunit in the peptidyl transferase center. Thanks to this, it rarely causes resistance among other groups of antibiotics and is characterized by a safe action profile. Its spectrum of action includes bacteria causing CABP. In phase III studies, the efficacy of lefamulin monotherapy was comparable to that of moxifloxacin with or without linezolid in CABP. Thanks to broad spectrum of action its usefulness may also extend to treatment of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and multidrug-resistant organisms associated with sexually transmitted infections, e.g., Neisseria gonorrhoeae, Mycoplasma genitalium, although more additional clinical and pharmacodynamic data is needed.
Conclusion. Lefamulin is a promising addition to the antibiotic armamentarium for treating CABP. Its unique mechanism of action, activity against typical and atypical bacteria, flexible dosing options, and favorable safety profile make it a beneficial choice for clinicians.
Interactive Evolutionary Design of Handbag Integrating Bamboo Weaving Material
Authors: Wu Yixiang , Han Xinghui 
Published: September 2023

Abstract
The integration and development of fashion products and intangible cultural heritage have gradually become the highlight of product design. Following thousands of years of evolution, bamboo weaving patterns offer a rich resource library for use by designers. However, the designers cannot predict which bamboo weaving pattern can be adopted into women’s handbags to satisfy consumers’ aesthetics. Therefore, taking the form design of women’s handbags as an example, this study develops an artificial intelligence-based program through which consumers can codesign with designers to effectively match the bamboo weaving pattern with the design style of women’s handbags. First, based on the coding, selection, and mutation processes of interactive genetic algorithms, consumer preferences, and perception evaluations are effectively incorporated into product design. This ensures that the evolved product solutions meet consumer preferences. Second, considering evaluator fatigue in human–computer interaction evaluation, the decision tree algorithm is used as a proxy for evaluation. Finally, the developed interactive system supports mass-generated bamboo-woven bags of different styles, allowing prediction of consumers’ preferences for the design of women’s handbags. Furthermore, the system can assist designers and bamboo craftsmen in designing other bamboo or wooden products.
Systematic errors in a swept-wavelength null polarimeter for weak linear retardance measurements
Authors: Theillier Xavier , Rivet Sylvain , Dubreuil Matthieu , Le Grand Yann 
Published: September 2023

We recently developed a high speed null polarimeter [Opt. Express 30, 18889 (2022)OPEXFF1094-408710.1364/OE.454193] based on passive polarization optics and a high speed wavelength swept laser source, enabling the measurement of linear retardance with 3.1µdeg/Hz resolution within a minimum acquisition time of 10 µs, corresponding to a linear retardation of 8.6×10−9λ/Hz. The counterpart of high sensitivity lies in the systematic errors unlike Mueller polarimeters, which can be calibrated but which are much less sensitive. This paper focuses on the accuracy of this null polarimeter and provides hardware and numerical solutions to improve both linear retardance and azimuth measurements. Experiments and theoretical simulations are carried out to demonstrate the relevancy of these solutions.
Efficient Parametric Downconversion by Gain-trapped OPA in Thin-film Lithium Niobate
Authors: Hamrouni Marin , Jankowski Marc , Hwang Alex , Jornod Nayara , Mishra Jatadhari , Stokowski Hubert , McKenna Timothy P. , Langrock Carsten , Südmeyer Thomas , Safavi-Naeini Amir H. , Fejer M. M. 
Published: September 2023

We demonstrate efficient optical parametric amplification in thin-film-lithium-niobate nanowaveguides dispersion-engineered to temporally trap the generated signal and idler. We observe parametric gains
>30 dB/pJ, enabling down-conversion of sub-10-pJ pump pulses to coherent 1.35-pJ idler pulses with a 140-nm-wide spectrum centered around 3200 nm.
Detection of per- and polyfluoroalkyl water contaminants with a multiplexed 4D microcavities sensor
Authors: Saetchnikov Anton V. , Tcherniavskaia Elina A. , Saetchnikov Vladimir A. , Ostendorf Andreas 
Published: September 2023

The per- and polyfluoroalkyl substances (PFAS) are a group of organofluorine chemicals treated as the emerging pollutants that are currently of particularly acute concern. These compounds have been employed intensively as surfactants over multiple decades and are already to be found in surface and ground waters at amounts sufficient to have an effect on human health and ecosystems. Because of the carbon–fluorine bonds, the PFAS have an extreme environmental persistence and their negative impact accumulates with further production and penetration into the environment. In Germany alone, more than thousands of sites have been identified as contaminated with PFAS; thus, timely detection of PFAS residue is becoming a high priority. In this paper, we report on the high performance optical detection method based on whispering gallery mode (WGM) microcavities applied for the first time to detect PFAS contaminants in aqueous solutions. A self-sensing boosted 4D microcavity fabricated with two-photon polymerization is employed as an individual sensing unit. In an example of the multiplexed imaging sensor with multiple hundreds of simultaneously interrogated microcavities we demonstrate the possibility to detect the PFAS chemicals representatives at a level down to 1 ppb (parts per billion).
Squeezed Matter-Wave Interferometer and Momentum Exchange Interaction in a High-Finesse Cavity
Authors: Luo Chengyi , Greve Graham P. , Koh Vanessa P. , Wu Baochen , Zhang Haoqing , Wilson John D. , Chu Anjun , Holland Murray J. , Rey Ana Maria , Thompson James K. 
Published: September 2023

An entanglement-enhanced matter-wave interferometer is demonstrated in a high-finessecavity with
1.7−0.5+0.5 dB directly observed phase resolution below the standard quantum limit. By exploiting the interaction between matter-wave and cavity, we also demonstrate a cavity-medicated momentum exchange interaction.
Evaluating the effectiveness and cost-effectiveness of a digital, app-based intervention for depression (VMood) in community-based settings in Vietnam: Protocol for a stepped-wedge randomized controlled trial
Authors: Chau Leena W. , Murphy Jill K. , Nguyen Vu Cong , Xie Hui , Lam Raymond W. , Minas Harry , Zheng Yufei , Krebs Emanuel , Hayashi Kanna , Dao Son , Nguyen Xuan , Duong Viet Anh , Fiume Eugene , O’Neil John 
Published: September 2023

The COVID-19 pandemic has amplified mental health problems and highlighted inequitable gaps in care worldwide. In response there has been an explosion of digital interventions such as smartphone applications (“apps”) to extend care. The objective of this trial is to evaluate the effectiveness and cost-effectiveness of a digital depression intervention (VMood), delivered via a smartphone app. VMood is adapted from an in-person intervention that was delivered by non-specialist providers and shown to be effective in the Vietnamese context in our previous trial (2016–2019). A stepped-wedge, randomized controlled trial will be conducted across eight provinces in Vietnam. Adults aged 18 years and over will be recruited through community-based primary care centres and screened for depression using the embedded Patient Health Questionnaire-9 (primary outcome measure). Participants scoring 10–19, indicating depression caseness, will be randomly allocated to the intervention or control group until the target of 336 is reached. Secondary outcome measures will examine the effect of the intervention on commonly co-occuring anxiety, quality of life and work productivity, along with use of alcohol and tobacco products. Assessments will be administered through an online survey platform (REDCap) at baseline, and at every 3 months until 3 months post-intervention. Intervention-group participants will receive VMood for a 3-month period, with online support provided by social workers. Control-group participants will receive a limited version of the app until they cross into the intervention group. Generalized Linear Mixed-effect Models for clustered measures will be used for all outcomes data. We will conduct a cost-effectiveness analysis alongside the trial to capture VMood’s costs and benefits. This trial will provide evidence on the effectiveness and cost-effectiveness of a digital mental health intervention adapted from an in-person intervention. This trial will also contribute important information to the growing and promising field of digital mental health.
Trail regulation. Registered at ClinicalTrials.gov, identifier [NCT05783531].
Historical Perspectives on Sustainable Fashion: Inspiration for Change, 2nd ed., Amy Twigger Holyroyd, Jennifer Farley Gordon and Colleen Hill (2023)
Authors: Sperling Joy 
Published: September 2023

Review of: Historical Perspectives on Sustainable Fashion: Inspiration for Change, 2nd ed., Amy Twigger Holyroyd, Jennifer Farley Gordon and Colleen Hill (2023)
London, New York, New Delhi and Sydney: Bloomsbury Visual Arts, 198 pp.,
ISBN 978-1-35016-044-6, h/bk, $100
ISBN 978-1-35016-043-9, p/bk, $34.95
ISBN 978-1-35016-043-9, e-PDF, $31.45
ISBN 978-1-35016-047-7, e-Pub, $31.45