bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Major Students’ Perception on the Application of Gamification and Simulation in Electrical and Electronics Engineering Courses at Universities in Malaysia
Authors: Saris Nur Najahatul Huda , Md Sapari Norazliani 
Published: May 2023

In the field of electrical and electronics (E&E) technology that is evolving rapidly, the Ministry of Higher Education Malaysia emphasizes universities to ensure that the expected non-major E&E engineering graduates are fully equipped with the skills to fulfil market needs. However, it is challenging for non-major students to understand the topics taught to them through the methods as they are conventionally being delivered. Therefore, gamification and simulation such as Kahoot, Quizizz, Multisim and CircuitMod have been applied in the university to facilitate formative assessment in order to enhance interest and understanding, and also accomplish learning more effectively among non-major students. Hence, this research aims to examine the non-major students’ perception of the implementation of gamification and simulation in class for face-to-face and online settings. To achieve this, a set of questionnaires was adapted with some modifications for the purpose of data collection. It was distributed to the students from random public universities in Malaysia who are currently enrolled in E&E engineering courses at their respective universities which majority of them are from a mechanical engineering background. Research questions concentrate on the advantages and students’ perceptions of gamification and simulation in E&E engineering courses. The collected data has been analyzed using descriptive statistical analysis. Based on the perceptions of the participating non-major E&E engineering students, the majority of the respondents agreed that gamification and simulation provide a better learning experience with the highest score mean of 4.22. Moreover, gamification and simulation boost students' ability to learn, motivate them, increase their understanding, promote their well-being, and increase their achievement academically. Students hold a positive perception with 4.20 mean score, stating that it is suitable for application in the learning process as it is easy to use, fun, motivating, and more efficient. The results provided would encourage educators in Malaysian universities to better meet the needs of teaching non-major students with their lessons.
Augmenting workload drives T‐tubule assembly in developing cardiomyocytes
Authors: Manfra Ornella , Louey Samantha , Jonker Sonnet S. , Perdreau‐Dahl Harmonie , Frisk Michael , Giraud George D. , Thornburg Kent L. , Louch William E. 
Published: May 2023

AbstractContraction of cardiomyocytes is initiated at subcellular elements called dyads, where L‐type Ca2+ channels in t‐tubules are located within close proximity to ryanodine receptors in the sarcoplasmic reticulum. While evidence from small rodents indicates that dyads are assembled gradually in the developing heart, it is unclear how this process occurs in large mammals. We presently examined dyadic formation in fetal and newborn sheep (Ovis aries), and the regulation of this process by fetal cardiac workload. By employing advanced imaging methods, we demonstrated that t‐tubule growth and dyadic assembly proceed gradually during fetal sheep development, from 93 days of gestational age until birth (147 days). This process parallels progressive increases in fetal systolic blood pressure, and includes step‐wise colocalization of L‐type Ca2+ channels and the Na+/Ca2+ exchanger with ryanodine receptors. These proteins are upregulated together with the dyadic anchor junctophilin‐2 during development, alongside changes in the expression of amphiphysin‐2 (BIN1) and its partner proteins myotubularin and dynamin‐2. Increasing fetal systolic load by infusing plasma or occluding the post‐ductal aorta accelerated t‐tubule growth. Conversely, reducing fetal systolic load with infusion of enalaprilat, an angiotensin converting enzyme inhibitor, blunted t‐tubule formation. Interestingly, altered t‐tubule densities did not relate to changes in dyadic junctions, or marked changes in the expression of dyadic regulatory proteins, indicating that distinct signals are responsible for maturation of the sarcoplasmic reticulum. In conclusion, augmenting blood pressure and workload during normal fetal development critically promotes t‐tubule growth, while additional signals contribute to dyadic assembly.
imageKey points
T‐tubule growth and dyadic assembly proceed gradually in cardiomyocytes during fetal sheep development, from 93 days of gestational age until the post‐natal stage.
Increasing fetal systolic load by infusing plasma or occluding the post‐ductal aorta accelerated t‐tubule growth and hypertrophy.
In contrast, reducing fetal systolic load by enalaprilat infusion slowed t‐tubule development and decreased cardiomyocyte size.
Load‐dependent modulation of t‐tubule maturation was linked to altered expression patterns of the t‐tubule regulatory proteins junctophilin‐2 and amphiphysin‐2 (BIN1) and its protein partners.
Altered t‐tubule densities did not influence dyadic formation, indicating that distinct signals are responsible for maturation of the sarcoplasmic reticulum.
Phyllodes tumour initially diagnosed as keloid
Authors: Ibrahimpur Sanjana Shivalingappa , Phulpagar Mayura , Jatale Ashish , Pandya Jayashri Sanjay 
Published: May 2023

It is unusual to find a breast tumour in a keloid, as the management of both is distinct. In this case, a young woman was operated on 4 years ago, for a right chest wall swelling, situated near the inframammary fold. The histopathological report revealed a granuloma, for which anti-tuberculosis treatment was given. However, the swelling recurred and progressed in size over the next 3 years. Then, she consulted the dermatology department, where the swelling was managed as a keloid. There was no remission. Consequently, the possibility of a breast tumour was suspected, and the patient was referred to breast services (subdivision of the surgery department).Triple assessment of the breast lump was suggestive of a phyllodes tumour (PT). Surgical excision of the tumour was done, which showed a malignant PT. Radiotherapy was given and delayed breast reconstruction was planned.
Structural and social determinants of mental health inequities among collegiate athletes during the COVID-19 pandemic
Authors: Kroshus Emily , Bell Lydia , Gurganus-Wright Kelsey , Hainline Brian 
Published: May 2023

ObjectivesTo characterise psychological distress during the COVID-19 pandemic among collegiate athletes and assess whether racial and ethnic differences in psychological distress are attenuated when accounting for inequitable exposure to structural and social determinants of health.MethodsParticipants were collegiate athletes on teams competing in the National Collegiate Athletic Association (n=24 246). An electronic questionnaire was distributed by email, open for completion 6 October to 2 November 2020. Multivariable linear regression models were used to assess the cross-sectional associations between meeting basic needs, death or hospitalisation due to COVID-19 of a close contact, race and ethnicity, and psychological distress.ResultsAthletes racialised as Black had higher levels of psychological distress than their white peers (B=0.36, 95% CI 0.08 to 0.64). Psychological distress was higher among athletes who had more difficulties meeting basic needs, and who had a close contact die or be hospitalised with COVID-19. After adjusting for these structural and social factors, Black athletes experienced less psychological distress than white peers (B=−0.27, 95% CI −0.54 to −0.01).ConclusionsThe present findings provide further evidence of how inequitable structural and social exposures are associated with racial and ethnic differences in mental health outcomes. Sports organisations should ensure the mental health services available for their athletes are appropriate for meeting the needs of individuals experiencing complex and traumatic stressors. Sports organisations should also consider whether there are opportunities to screen for social needs (eg, related to food or housing insecurity), and to connect athletes with resources to help meet those needs.
Facies-related diagenesis of Jurassic sandstones, central Junggar Basin, NW China: implications for reservoir quality evolution
Authors: Zhang Penghui , Lee Yong Il 
Published: May 2023

Abstract

Hydrocarbon exploration in China has recently expanded to deep tight oil and gas from the Lower Jurassic sandstone reservoirs in the central Junggar Basin. These deeply buried sandstones (>4.5 km) have generally been overpressured due to hydrocarbon saturation, but have not been intensively investigated in terms of diagenesis and reservoir quality. The Lower Jurassic sandstones are feldspathic litharenites (average Q
28
F
29
R
43
) and were deposited in the lacustrine–deltaic environments of the high-palaeolatitude continental basin under warm, humid climatic conditions. Progressive burial with only slight uplift of the strata led to a relatively stable burial–thermal regime, resulting in minor diagenetic changes consisting of compaction, cementation by carbonates, quartz and clay minerals, and partial dissolution of feldspars and rock fragments. Despite generally similar diagenetic histories, the studied sandstones reveal considerable variations in the development of pore systems, porosity and permeability. The best reservoirs are represented by medium- to coarse-grained depositional facies with higher porosity (average 8.43%) and permeability (average 0.59 mD). All the evidence suggests that integrated consideration of the roles of depositional settings and diagenesis, linked with burial–thermal history and overpressure evolution conditions, provides a helpful means of predicting reservoir quality.
Training the creation, visualization and interpretation of fault maps for the subsurface – using tectonic geomorphology
Authors: Butler Robert W. H. 
Published: May 2023

Abstract
Fault mapping is essential for understanding subsurface geological structure. However, effective training of students in developing and understanding fault patterns in 3D seismic imagery is impeded by the time-investment needed to acquire competence using software and then creating depth-structure maps of stratal horizons. Here an exercise is laid out that can achieve the desired experience – using the young fault systems of Afar (Djibouti), where former land-surface-defining basalt flows are offset by arrays of normal faults. The top-basalt surface, displayed on GoogleEarth, is in effect a depth-structure map and the gaps (‘fault-loss’) in this surface approximate to exposed fault surfaces. The mapping exercise is described and illustrated here step-wise. The fault system is gradually mapped out to reveal examples of long-continuous faults, branching patterns, relaying faults and isolated fault segments. Alternative criteria for identifying faults can be examined, with analogies in seismic interpretation. This can inform discussion of the approaches and uncertainties inherent in mapping faults in the subsurface. The study may be extended to consider the pattern of early–syn-rift depositional systems. Collectively these tasks can be progressed within an hour or so, providing effective insights into the structure of normal fault systems that cannot be replicated by conventional fieldwork.
CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling
Authors: Wang Yihui , Wang Jizheng , Shi Ling , Chen Xiuyu , Li Desheng , Cui Chen , Yang Kai , Lu Minjie , Huang Jinhua , Zhang Lei , Li Fei , Wang Jinxi , Chen Biyi , Wang Bin , Hall Duane D. , Pan Zhenwei , Hong Jiang , Song Long-Sheng , Song Lei , Zhao Shihua 
Published: May 2023

Background:
Atrial fibrillation (AF) is a highly prevalent condition that can cause or exacerbate heart failure, is an important risk factor for stroke, and is associated with pronounced morbidity and death. Genes uniquely expressed in the atria are known to be essential for maintaining atrial structure and function. Atrial tissue remodeling contributes to arrhythmia recurrence and maintenance. However, the mechanism underlying atrial remodeling remains poorly understood. This study was designed to investigate whether other uncharacterized atrial specific genes play important roles in atrial physiology and arrhythmogenesis.

Methods:
RNA-sequencing analysis was used to identify atrial myocyte specific and angiotensin II–responsive genes. Genetically modified, cardiomyocyte-specific mouse models (knockout and overexpression) were generated. In vivo and in vitro electrophysiological, histology, and biochemical analyses were performed to determine the consequences of CIB2 (calcium and integrin binding family member 2 protein) gain and loss of function in the atrium.

Results:

Using RNA-sequencing analysis, we identified CIB2 as an atrial-enriched protein that is significantly downregulated in the left atria of patients with AF and mouse models of AF from angiotensin II infusion or pressure overload. Using cardiomyocyte-specific C
ib2
knockout (
Cib2

-/
-

) and atrial myocyte–specific
Cib2
-overexpressing mouse models, we found that loss of C
ib2
enhances AF occurrence, prolongs AF duration, and correlates with a significant increase in atrial fibrosis under stress. Conversely,
Cib2
overexpression mitigates AF occurrence and atrial fibrosis triggered by angiotensin II stress. Mechanistically, we revealed that CIB2 competes with and inhibits CIB1-mediated calcineurin activation, thereby negating stress-induced structural remodeling and AF.

Conclusions:
Our data suggest that CIB2 represents a novel endogenous and atrial-enriched regulator that protects against atrial remodeling and AF under stress conditions. Therefore, CIB2 may represent a new potential target for treating AF.
Investigation of the mechanical properties triple periodic minimal surfaces lattice structures with functional graded of porosity
Authors: Emir Ender , Bahçe Erkan 
Published: May 2023

In recent years, triple periodic minimal surfaces (TPMS) have attracted attention in many applications such as biomaterials, aerospace, defense industry etc. lightweight components with high strength and functionally graded material (FGM). In particular, the mechanical properties and deformation behavior of these structures under load should be examined. In this study, it was aimed to evaluate the manufacturability and mechanical performance of fixed pore size and functional graded porosity (FGP) lattice structures produced by fused deposition modelling (FDM) method. TPMS primitive and gyroid lattice structures designed in the dimensions of 20 × 20 × 20 mm with fixed 20% pore size and functional graded (FG) from 20% to 40% pore size were used in the experiments. In order to reveal the effects of pore size on mechanical performance, uniaxial compression tests were carried out. In addition, for the validation of the experimental results, compression tests with the finite element method (FEM) were simulated for each sample. In the two different pore size changes tested in the study, the gyroid lattice structure showed the highest mechanical performance compared to the primitive lattice structure. In addition, the FEM results were in good agreement with the experimental results.
Provision of Postpartum Contraception Before and After the Start of the COVID-19 Pandemic in Maine
Authors: Gelsinger Catherine , Palmsten Kristin , Lipkind Heather S. , Pfeiffer Mariah , Ackerman-Banks Christina , Hutcheon Jennifer A. , Ahrens Katherine A. 
Published: May 2023

Objective: Preliminary findings from selected health systems revealed interruptions in reproductive health care services due to the COVID-19 pandemic. We estimated changes in postpartum contraceptive provision associated with the start of the COVID-19 pandemic in Maine. Methods: We used the Maine Health Data Organization’s All Payer Claims Database for deliveries from October 2015 through March 2021 (n = 45 916). Using an interrupted time-series analysis design, we estimated changes in provision rates of long-acting reversible contraception (LARC), permanent contraception, and moderately effective contraception within 3 and 60 days of delivery after the start of the COVID-19 pandemic. We performed 6- and 12-month analyses (April 2020–September 2020, April 2020–March 2021) as compared with the reference period (October 2015–March 2020). We used Poisson regression models to calculate level-change rate ratios (RRs) and 95% CIs. Results: The 6-month analysis found that provision of LARC (RR = 1.89; 95% CI, 1.76-2.02) and moderately effective contraception (RR = 1.51; 95% CI, 1.33-1.72) within 3 days of delivery increased at the start of the COVID-19 pandemic, while provision of LARC (RR = 0.95; 95% CI, 0.93-0.97) and moderately effective contraception (RR = 1.08; 95% CI, 1.05-1.11) within 60 days of delivery was stable. Rates of provision of permanent contraception within 3 days (RR = 0.70; 95% CI, 0.63-0.78) and 60 days (RR = 0.71; 95% CI, 0.63-0.80) decreased. RRs from the 12-month analysis were generally attenuated. Conclusion: Disruptions in postpartum provision of permanent contraception occurred at the beginning of the COVID-19 pandemic in Maine. Public health policies should include guidance for contraceptive provision during public health emergencies and consider designating permanent contraception as a nonelective procedure.
Just because I can’t say words, doesn’t mean I can’t have a choice
Authors: Keenan Amy 
Published: May 2023

People with physical disabilities and age-appropriate cognitive levels of functioning can experience incredible frustration in their opportunities to express and communicate along with societal stigma and assumptions. Dramatherapy, and specifically Drama and Movement Therapy, can be an effective therapeutic method in providing a platform for these clients to find their voice through a range of techniques and stimulation. Providing ‘choice’, building a non-judgemental, trusting therapeutic relationship, along with enabling the client is an essential part of this process. This article will discuss a Dramatherapist’s experience from an autoethnological perspective with her own limitations in using her voice, in relation to working and enabling non-verbal clients. This will further be supported by case studies, demonstrating working within an effective multidisciplinary team. Joint working will be discussed along with examples of a range of creative and adaptable techniques to assist the individual and their needs. The article will then discuss and conclude with how practitioners can assist these clients to find their voice, by supporting different ways of communication and importantly providing choice.
Relationship between patellofemoral joint morphology and chondromalacia patella
Authors: Öztürk Cansu , Güngör Özlem 
Published: May 2023

Background For the normal functioning of the patellofemoral joint (PF), the relationship between the patella and the trochlear groove must be compatible. Purpose To investigate the relationship between patellofemoral joint morphology (PFM) and patellar chondromalacia. Material and Methods Overall, 136 knees of patients aged 20–55 years examined between March 2020 and March 2021 were included in this study. In all patients, trochlear sulcus angle, trochlear sulcus depth, trochlear facet asymmetry, patella alta (Insall–Salvati [IS] index), and patellar facet asymmetry were measured. Of these cases, 66 knees with an abnormality detected in any of the measurements for PFM were included in the case group. Moreover, 70 knees with demonstrating normal PFM measurements were included in the control group. Results The incidence and grade of chondromalacia was higher in the case group than in the control group ( P < 0.001). Between the patients with and without chondromalacia trochlear sulcus angle (mean = 138.25° ± 10.02° vs. 132.58° ± 7.24°; P = 0.001), IS index (mean = 1.25 ± 0.21 vs. 1.16 ± 0.15; P = 0.014), patellar facet asymmetry (mean = 0.77 ± 0.09 vs. 0.73 ± 0.12; P = 0.039), trochlear sulcus depth (mean = 5.39 ± 1.42 mm vs. 6.27 ± 1.04 mm; P < 0.001), and trochlear facet asymmetry (mean = 0.67 ± 0.11 vs. 0.71 ± 0.09; P = 0.023) measurements, there was a significant difference. Conclusion The presence of at least one of the measures indicating pathology in PFM is associated with the presence and severity of chondromalacia.
The need for prophylactic hemodialysis to protect against nephrogenic systemic fibrosis in patients with end-stage renal disease receiving gadolinium-based contrast agents
Authors: Lee Yeonhee , Kim Junghoon , Kwon Soie , Jeong Jong Cheol , Joo Kwon Wook , Oh Kook-Hwan 
Published: May 2023

Background The risk of gadolinium (Gd)-based contrast agent (GBCA)-induced nephrogenic systemic fibrosis (NSF) in patients with end-stage renal disease (ESRD) and the efficacy of prophylactic hemodialysis (HD) for protection against NSF are not well understood or summarized in the literature. Purpose To determine the risk for NSF related to frequency and time per dialysis session after Gd-magnetic resonance imaging (MRI) by emphasizing the safety of Gd-MRI in patients with ESRD. Material and Methods This retrospective observational study identified all GBCA injections for MRI examinations performed at two tertiary referral hospitals between 2005 and 2020. All clinical data, including dialysis records and medical history, were investigated for each patient through 2021. The end of follow-up coincided with the last hospital visit. Results Overall, 1129 patients with ESRD underwent 1461 Gd-MRI scans (41.5% gadoterate, 39.4% gadobutrol, and 7.7% gadoxetate); a total of 958 patients with 1229 (84.1%) examinations underwent HD on the day of the MRI study, within 2.1 ± 2.0 h (range = 0.2–15.7 h) immediately after Gd exposure. In 53.4% of scans, frequent HD had been performed urgently and then twice more on consecutive days to prophylactically avoid NSF. No cases of NSF were identified during the follow-up period (mean = 81.7 ± 50.5 months) regardless of dose of HD. Conclusion No cases of NSF were reported in 1461 Gd-MRI examinations of 1129 inpatients with ESRD on HD. Our findings support the lack of benefit of frequent prophylactic HD being performed urgently within 4 h of the receipt of GBCA.