bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Intelligence in Estimating Fractional Flow Reserve: A Systematic Literature Review
Authors: Arefinia Farhad , Rabiei Reza , Hosseini Azamossadat , Ghaemian Ali , Roshanpoor Arash , Aria Mehrad , Khorrami Zahra 
Published: June 2023

Abstract
Background
Fractional Flow Reserve (FFR) is the gold standard for the functional evaluation of coronary arteries, which is effective in selecting patients for revascularization, avoiding unnecessary procedures, and reducing treatment costs. However, its use is limited due to invasiveness, high cost, and complexity. Therefore, the non-invasive estimation of FFR using artificial intelligence (AI) methods is crucial.
Objective
This study aimed to identify the AI techniques used for FFR estimation and to explore the features of the studies that applied AI techniques in FFR estimation.
Methods
The present systematic review was conducted by searching five databases, PubMed, Scopus, Web of Science, IEEE, and Science Direct, based on the search strategy of each database.
Results
Five hundred seventy-three articles were extracted, and by applying the inclusion and exclusion criteria, twenty-five were finally selected for review. The findings revealed that AI methods, including Machine Learning (ML) and Deep Learning (DL), have been used to estimate the FFR.
Conclusion
This study shows that AI methods can be used non-invasively to estimate FFR, which can help physicians diagnose and treat coronary artery occlusion and provide significant clinical performance for patients.
Noninvasive deep brain stimulation via temporal interference electric fields enhanced motor performance of mice and its neuroplasticity mechanisms
Authors: Liu Xiaodong , Qi Shuo , Hou Lijuan , Liu Yu , Wang Xiaohui 
Published: June 2023

Abstract
A noninvasive deep brain stimulation via temporal interference (TI) electric fields is a novel neuromodulation technology, but few advances about TI stimulation effectiveness and mechanisms have been reported. In the present study, TI stimulation was proved to stimulating noninvasively primary motor cortex (M1) of mice, and 7 days TI stimulation with an envelope frequency of 20 Hz (∆f = 20 Hz), instead of an envelope frequency of 10 Hz (∆f = 10 Hz), could obviously improve mice motor performance. The mechanism of action may be related to enhancing the strength of synaptic connections, improving synaptic transmission efficiency, increasing dendritic spine density, promoting neurotransmitter release, and increasing the expression and activity of synapse-related proteins, such as brain-derived neurotrophic factor (BDNF), postsynaptic density protein-95 (PSD-95), and glutamate receptor protein. Furthermore, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway and its upstream BDNF play an important role in the enhancement of locomotor performance in mice by TI stimulation. To our knowledge, it is the first report about TI stimulation promoting multiple motor performances and describing its mechanisms. TI stimulation might serve as a novel promising approach to enhance motor performance and treat dysfunction in deep brain regions.
Deep learning models predicting hormone receptor status in breast cancer trained on females do not generalize to males: further evidence of sex-based disparity in breast cancer
Authors: Chatterji Subarnarekha , Niehues Jan , Treeck Marko van , Loeffler Chiara , Saldanha Oliver , Veldhuizen Gregory , Cifci Didem , Carrero Zunamys , Abu-Eid Rasha , Kather Jakob , Speirs Valerie 
Published: June 2023

Abstract
Breast cancer prognosis and management for both men and women are reliant upon estrogen receptor alpha (ERα) and progesterone receptor (PR) expression to inform therapy. Previous studies have shown that there are sex-specific binding characteristics of ERα and PR in breast cancer and, counterintuitively, ERα expression is more common in male than female breast cancer. We hypothesized that these differences could have morphological manifestations that are undetectable to human observers but could be elucidated computationally. To investigate this, we trained attention-based multiple instance learning prediction models for ERα and PR using H&E-stained images of female breast cancer from the Cancer Genome Atlas (TCGA) (n = 1085), and deployed them on external female (n = 192) and male breast cancer images (n = 245). Both targets were predicted in the internal (AUROC for ERα prediction: 0.86 ± 0.02, p < 0.001; AUROC for PR prediction = 0.76 ± 0.03, p < 0.001) and external female cohorts (AUROC for ERα prediction: 0.78 ± 0.03, p < 0.001; AUROC for PR prediction = 0.80 ± 0.04, p < 0.001) but not the male cohort (AUROC for ERα prediction: 0.66 ± 0.14, p = 0.43; AUROC for PR prediction = 0.63 ± 0.04, p = 0.05). This suggests that subtle morphological differences invisible upon visual inspection may exist between the sexes, supporting previous immunohistochemical, genomic, and transcriptomic analyses.
Translation, adaptation and psychometric evaluation of the Quality of Life in a Child’s Chronic Disease Questionnaire for the Swedish context
Authors: Blomberg Karin , Farnik Małgorzata , Eriksson Mats 
Published: June 2023

Abstract
Background
It is well known that a child’s illness influences the health and wellbeing of the child’s parents, who play a central role in coping with the disease in the family’s everyday life. It is crucial to develop and test interventions supporting the family during these circumstances. However, there is a lack of instruments to evaluate the effects of such interventions on family and psychosocial aspects of parental functioning. The aim of this study was therefore to translate, adapt and psychometrically evaluate the Quality of Life in a Child’s Chronic Disease Questionnaire (QLCCDQ) for the Swedish context.
Methods
The QLCCDQ was translated into Swedish and adapted to the Swedish context. Data for psychometric testing were obtained through a survey of parents of children and adolescents (n = 627) with chronic diseases: asthma and type 1 diabetes mellitus, with a total of 173 responses (27.6%). Face and content validity of the instrument was assessed, and floor and ceiling effects were measured. Internal consistency was measured with Cronbach’s alpha and an explanatory factor analysis (EFA) was conducted.
Results
The EFA gave a two-factor solution with an eigenvalue > 1 explaining 73.9% of total variance for the Swedish version.
Conclusion
The study concludes that the Swedish version of the QLCCDQ is a reliable and valid questionnaire.
Run-up velocity and pedaling power of male elite gymnasts on vault in China
Authors: yingjun nie , Zhenke Tan , Yao Xiaozhi , Ma Yuanyan , Bi Ye , Gao Yijia 
Published: June 2023

Abstract
A high run-up speed and a big pedaling power are crucial to perform difficult movements and improving the quality of movement performance in the competition vault. We aimed to investigate the interrelations between different run-up speeds and pedaling power to explore the different requirements of performing different vault styles as well as difficult movements on run-up speed and pedaling power. The data of 30 male elite gymnasts were included in the analysis. Binary logistic regression analysis were used for statistical analysis. We found that the special requirement for run-up speed and pedaling power may vary as the difficult vault. There was no significant difference in the pedaling run-up speed between the Front handspring types and Cartwheel types (p > 0.05), but the run-up speeds were significantly associated with D-score in some vault types (p < 0.05). The comparison between interval run-up speeds revealed that the last 5m run-up speeds were faster during the 25m run-up distance, and 30m sprint speed was strongly associated with the 25m vaulting run-up speed of Handspring and Cartwheel (r = 0.81, p < 0.01). Pedaling power was significantly associated with vault types (p < 0.05) as well as D-score (p < 0.01) and obviously increased when the D-score was above 4.6. Pedaling power was strongly correlated with 25m run-up speed (r = 0.715, p < 0.01), last 5m run-up speed ( r = 0.718, p < 0.01), and 30m sprint speed (r = 0.704, p < 0.01) respectively, but not significantly associated with last 10-5m run-up speed as well as before the last 10m run-up speed (p > 0.05).
The effect of caponization on bone homeostasis of crossbred roosters. I. Analysis of tibia bone mineralization, densitometric, osteometric, geometric and biomechanical properties
Authors: Wojciechowska-Puchałka J. , Calik J. , Krawczyk J. , Obrzut J. , Tomaszewska E. , Muszyński S. , Wojtysiak D. 
Published: June 2023

Abstract
The presented study focuses on assessing the effect of caponization on the densitometric, osteometric, geometric and biomechanical parameters of tibial bones in crossbred chickens. The study was carried out on 96 hybrids between Yellowleg Partridge hens (Ż-33) and Rhode Island Red cockerels (R-11) aged 16 weeks, 20 weeks and 24 weeks. Birds were randomly assigned to 2 groups – the control group (n = 48; which consisted of intact roosters) and the experimental group (n = 48, which consisted of individuals subjected to caponization at the age of 8 weeks). The caponization had no effect on the densitometric, osteometric and geometric parameters (except the horizontal internal diameter of 16-week-old individuals) of tibia bone, as well as the content of calcium (Ca), phosphorus (P) and the Ca/P ratio in the bone mineral fraction in all analyzed age groups of animals. However, it contributes to a lower percentage of ash in the bones of capons at 20 and 24 weeks of age compared to cockerels. On the contrary, some mechanical and material parameters show the negative effect of caponization. Ultimate load and bending moment decreased in capons in all of the analyzed age groups of animals and yield load, stiffness and ultimate stress also decreased but only in the group of 20-week-old and 24-week-old individuals. This can contribute to the weakening of the capon bones, and in the perspective of prolonged maintenance to their deformation and even fracture.
Body surface area is a predictor of maturity status in school children and adolescents
Authors: Vasquez Fernando Alvear , Vidal-Espinoza Rubén , Gómez-Campos Rossana , de Campos Luis Felipe Castelli Correia , Lazari Evandro , Luján Jose Francisco Guzmán , Pablos Ana , Cossio-Bolaños Marco 
Published: June 2023

Abstract
Background
Generally, Body surface area (BSA) changes significantly during growth and maturation. These increases portend a possible relationship between body size as determined by BSA with maturational status in children and adolescents.
Objective
To determine the relationship between maturity status (MS) obtained by non-invasive anthropometric methods and body surface area (BSA) in children and adolescents of both sexes in a regional population of Chile. Additionally, we sought to verify the type of linear or nonlinear relationship between MS and BSA in both sexes.
Methods
A descriptive (cross-sectional) study was designed in 950 children and adolescents of both sexes (539 males and 411 females). The age range ranged from 6.0 to 17.9 years. Anthropometric measurements were evaluated: body weight, standing height, sitting height. MS was assessed by means of two non-invasive anthropometric techniques. Both techniques predict peak years of growth velocity (APHV) through a regression equation for each sex. BSA (m2) was estimated by means of the Haycock equation.
Results
The R2 in the linear model is relatively lower (R2 = 0.80 to 0.89 in males and 0.74 to 0.66 in females) in relation to the nonlinear quadratic model (R2 = 0.81 in males and 0.76 to 0.69). The quadratic nonlinear quadratic model reflected an adequate fit (RMSE) for the data set, being in men (RMSE = 1.080 and 1.125), while in women (RMSE = 1.779 and 1.479).
Conclusion
BSA is positively associated with MS determined by two non-invasive methods in Chilean children and adolescents: The nonlinear quadratic model was a better fit to the data distribution. The results suggest the use of BSA as a possible predictor of maturity status in Chilean youth.
Evaluation of diets with fresh fruit for reproduction of Drosophila suzukii (Diptera: Drosophilidae) under laboratory conditions
Authors: Tadeo Eduardo , Lima Itzel , Martinez María de Jesús , Ruiz-Montiel Cesar 
Published: June 2023

Abstract
The main challenge for the establishment of colonies of Drosophila suzukii is the provision of a suitable diet that facilitates their reproduction and maintenance in the laboratory. The use of a standard diet, developed for the reproduction of D. melanogaster and commonly used for the establishment and maintenance of D. suzukii colonies, has brought considerable problems. This study evaluated a series of diets based on fresh fruit and others based on maize flour with the addition of regional fruit and berry juice aimed at counteracting the low effectiveness of the standard diet based on maize flour. Our results show the clear superiority of the diet based on fresh fruit (strawberry and banana) over those based on maize flour, in terms of the reproduction y establishment of D. suzukii colonies under laboratory conditions.
Pharmacoeconomic evaluation of isavuconazole, posaconazole and voriconazole in the treatment of invasive fungal infection: initial therapy prior to pathogen differential diagnosis in China
Authors: Han Guangxin , Xu Qing , Lv Qianzhou , Li Xiaoyu , Shi Xiaoping 
Published: June 2023

Abstract

BackgroundInvasive fungal infections (IFIs) is associated with high mortality and a substantial economic burden. For high-risk patients, fever drive or diagnostic drive therapy is usually initiated prior to the differential diagnosis of the pathogen. This study evaluated the cost-effectiveness of isavuconazole, posaconazole, versus voriconazole in the treatment of invasive fungal infections from the perspective of the Chinese healthcare system, informing healthcare decision-making and resource allocation.MethodsA decision analytic model was constructed using TreeAge Pro 2011 software to evaluate the cost-effectiveness of the entire disease course. We assumed that the prevalence of mucormycosis in the patients entering the model was 7.8%. Efficacy, cost, adverse events, and other data included in the model were mainly derived from clinical studies, published literature, and publicly available databases. The primary outcomes of the model output were total cost, quality-adjusted life years (QALYs), life years (Lys), and incremental cost-effectiveness ratio (ICER). The willing-to-pay (WTP) threshold was defined as one to three times China’s GDP per capita in 2022. One-way sensitivity analysis and probability sensitivity analysis were used to determine the robustness of the model. At the same time, the cost-effectiveness of three triazole antifungal agents under a broader range of mucormycosis prevalence, when voriconazole was covered by medical insurance reimbursement, and after the price reduction of posaconazole was discussed.ResultsBase-case analysis showed that isavuconazole had greater efficacy (+ 0.38 LYs and + 0.31 QALYs) than voriconazole; ICER was $15,702.46 /QALY, well below the WTP threshold ($38,223 /QALY). However, posaconazole did not provide a significant economic advantage over voriconazole (ICER $64,466.57 /QALY). One-way sensitivity analysis found that ICER was highly sensitive to the mortality of patients with invasive aspergillus infection. In the probabilistic sensitivity analysis, when the WTP threshold was $38223 /QALY, the probability of isavuconazole being cost-effective was 72.9%. The scenario analysis results indicated that posaconazole would become cost-effective when the price was reduced by 15% or the prevalence of mucormycosis was 14%.ConclusionsIsavuconazole represents a cost-effective initial option for treating IFIs in high-risk patients prior to the differential diagnosis of pathogens. It will also be economical when a 15% reduction in posaconazole cost is achieved.
Asymmetric quantum decision-making
Authors: Shiratori Honoka , Shinkawa Hiroaki , Röhm André , Chauvet Nicolas , Segawa Etsuo , Laurent Jonathan , Bachelier Guillaume , Yamagami Tomoki , Horisaki Ryoichi , Naruse Makoto 
Published: June 2023

Abstract
Collective decision-making is crucial to information and communication systems. Decision conflicts among agents hinder the maximization of potential utilities of the entire system.Quantum processes can realize conflict-free joint decisions among two agents using the entanglement of photons or quantum interference of orbital angular momentum (OAM). However, previous studies have always presented symmetric resultant joint decisions. Although this property helps maintain and preserve equality, it cannot resolve disparities. Global challenges, such as ethics and equity, are recognized in the field of responsible artificial intelligence as responsible research and innovation paradigm. Thus, decision-making systems must not only preserve existing equality but also tackle disparities. This study theoretically and numerically investigates asymmetric collective decision-making using quantum interference of photons carrying OAM or entangled photons. Although asymmetry is successfully realized, a photon loss is inevitable in the proposed models. The available range of asymmetry and method for obtaining the desired degree of asymmetry are analytically formulated.
Exploring the tradeoff between data privacy and utility with a clinical data analysis use case: a case report
Authors: Im Eunyoung , Kim Hyeoneui , Lee Hyungbok , Jiang Xiaoqian , Kim Ju Han 
Published: June 2023

Abstract
Securing adequate data privacy is critical for the productive utilization of data. De-identification, involving masking or replacing specific values in a dataset, could damage the dataset’s utility. However, finding a reasonable balance between data privacy and utility is not straightforward. Nonetheless, few studies investigated how data de-identification efforts affect data analysis results. This study aimed to demonstrate the effect of different de-identification methods on a dataset’s utility with a clinical analytic use case and assess the feasibility of finding a workable tradeoff between data privacy and utility. Predictive modeling of emergency department length of stay was used as a data analysis use case. A logistic regression model was developed with 1155 patient cases extracted from a clinical data warehouse of an academic medical center located in Seoul, South Korea. Nineteen de-identified datasets were generated based on various de-identification configurations using ARX. The variable distributions and prediction results were compared between the de-identified datasets and the original dataset to observe the association between data privacy and utility, and to determine whether it is feasible to identify a viable tradeoff between the two. The findings of this study demonstrated that securing data privacy resulted in some loss of data utility. Due to the complexity of the process of ensuring data privacy while maintaining utility understanding the purpose of data use may be required. Including the data user in the data de-identification process may be helpful in the effort to find an acceptable tradeoff between data privacy and utility.
Clinical and Immunological Characteristics of Prolonged SARS-CoV-2 Omicron Infection in Hematologic Disease
Authors: Ikeda Daisuke , Fukumoto Ami , Uesugi Yuka , Tabata Rikako , Miura Daisuke , Narita Kentaro , Takeuchi Masami , Watari Tomohisa , Otsuka Yoshihito , Matsue Kosei 
Published: June 2023

Abstract
Prolonged viral shedding (PVS) occurs when severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is not adequately cleared and has been associated with poor outcomes. However, it remains unclear whether the immunological and clinical characteristics of Omicron PVS in hematologic disease (HD) are identical to those of earlier variants. We retrospectively analyzed 160 patients with HD with Omicron breakthrough infections. Although the hospitalization rate was high (21.3 %), deaths attributable to COVID-19 occurred in only 2.5% of the cases. PVS developed in 36.9% of the evaluable patients. Factors such as B- and CD4+ T-cell depletion, recent use of anti-CD20 antibodies and bendamustine were found to be significant predictors of PVS. Analysis of T cell phenotypes showed an increase in exhausted CD4+ T cells in PVS, but not in CD8+ cells. Neutralizing activities against recombinant spike proteins for three Omicron subvariants were significantly reduced. Notably, despite the high frequency of PVS, many patients previously treated with anti-CD20 antibodies and bendamustine ultimately recovered. Late-onset interstitial pneumonia is a fatal complication that can occur regardless of viral clearance. Despite the use of high-dose corticosteroids and potent antivirals, the optimal treatment for PVS remains unclear and should be individualized until a more effective strategy is established.
Detection of APP gene recombinant in human blood plasma
Authors: Mitsunaga Shigeki , Fujito Naoko , Nakaoka Hirofumi , Imazeki Ryoko , Nagata Eiichiro , Inoue Ituro 
Published: June 2023

Abstract
The pathogenesis of Alzheimer's disease (AD) is believed to involve the accumulation of amyloid-β in the brain, which is produced by the sequential cleavage of amyloid precursor protein (APP) by β-secretase and γ-secretase. Recently, analysis of genomic DNA and mRNA from postmortem brain neurons has revealed intra-exonic recombinants of APP (gencDNA), which have been implicated in the accumulation of amyloid-β. In this study, we computationally analyzed publicly available sequence data (SRA) using probe sequences we constructed to screen APP gencDNAs. APP gencDNAs were detected in SRAs constructed from both genomic DNA and RNA obtained from the postmortem brain and in the SRA constructed from plasma cell-free mRNA (cf-mRNA). The SRA constructed from plasma cf-mRNA showed a significant difference in the number of APP gencDNA reads between SAD and NCI: the p-value from the Mann-Whitney U test was 5.14x10− 6. The transcripts were also found in circulating nucleic acids (CNA) from our plasma samples with NGS analysis. These data indicate that transcripts of APP gencDNA can be detected in blood plasma and suggest the possibility of using them as blood biomarkers for Alzheimer's disease.