bluuebunny/crossref_metadata_2025_split huggingface dataset:
FEATURES OF MYOCARDIA DEFORMATION PROPERTIES IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Bekmetova Sevara , Abdullaeva Guzal , Khamidullaeva Gulnoz , Yusupova Khafiza 
Published: June 2023

Objective:
Determination of myocardium deformation properties depending on degree of arterial hypertension and the presence/absence of left ventricular hypertrophy (LVH) in patients with arterial hypertension.

Design and method:
74 patients of both sexes, with I–III degrees of AH (ESC/ESH, 2018) were studied. Average age of patients was 58.72 ± 11.9 years; AH duration was 10.8 ± 7.2 years. Speckle-tracking EchoCG was performed to obtain an objective and quantitative assessment of global and regional myocardial function using the ACUSON x 700 PV 2.0 manufactured by SIEMENS. Among the parameters for assessing the longitudinal deformation of the left ventricle, we have chosen: global longitudinal strain -GLS (%); Strain Rate-SR. To study the segmental LV contractility, analyzed the apical 4-chamber, 3-chamber and 2-chamber section. Results are presented as M±SD.

Results:
The patients were divided into 3 groups: I- patients with AH I degree, n = 21 (28.4%); II n = 28 patients with II degree of AH (37.8%); III n = 25 (33.8%) patients with III degree of AH. A comparative analysis of groups showed that in patients with grade III AH, the indicators of GLS and the rate of myocardial deformation are significantly lower than in groups of patients with grades I and II of AH. The index of GLS in group III was: 10.3±3.6%, while in group I - 18.1±4.4% and in group II - 11.8% (p = 0.000). The same was noted in terms of SR: 1.0±0.3 s-1 versus 1.5±0.6 s-1 and 1.1±0.5 s-1, respectively (p = 0.001). To study the deformation properties of the myocardium, patients were divided into 2 groups: patients with LVH and without LVH. In 1st group, the GLS index was lower, 14.9±5.8%, than in 2nd group – 17.9±6.1% (p<0.05); the SR index in the group of patients with LVH was also lower- 1.64±0.75 s-1, than in the group of patients without LVH - 1.87±0.81 s-1 (p<0.05).

Conclusions:
Thus, significant violations of the deformation properties of LV are formed in patients with AH with an increase of degree of AH and the presence of LVH.
METABOLIC PREDICTORS OF TARGET ORGAN DAMAGE IN ESSENTIAL HYPERTENSION
Authors: Allievi Luca , Gherbesi Elisa , Meazza Roberto , Villarini Anna , Lombardi Federico , Carugo Stefano 
Published: June 2023

Objective:
First, to verify the relationship between hypertension-mediated organ damage (HMOD) and measures of abdominal obesity in essential hypertension. Secondly, to evaluate which condition between overweight (BMI>25 kg/m2), high waist circumference (WC>80/94 cm in females/males) and waist-to-height ratio (WHtR>0.54) is more predictive of HMOD.

Design and method:
We selected a cohort of adult treated essential hypertensive subjects followed at our Hypertension Center. Blood pressure (BP), height, weight and WC were measured in all subjects. Various investigations were also performed to identify HMOD, such as echocardiography, carotid ultrasound, carotid-femoral pulse wave velocity (PWV) and fundoscopy.

Results:
114 subjects were enrolled (46/68 females/males, mean age 69±2 years, mean BP 135/77±3/2 mmHg). WC and WHtR were higher in patients with all expressions of HMOD except for hypertensive retinopathy. In particular, left ventricular mass index (LVMi/BSA) correlates with WHtR (p<0.05), while in obese subjects, in which ventricular mass was indexed as LVMi/h2.7, both WC and WHtR significantly correlate (p<0.05). In subjects with WHtR>0.54, there was a significant risk of increased arterial stiffness by PWVs (OR = 2.479, p = 0.04). This data is confirmed in subjects with BMI>25 kg/m2 (OR = 2.888, p = 0.04) but not in subjects with BMI<25 kg/m2, while no significance was observed for high WC. In the presence of HMOD, a significantly higher number of metabolic syndrome factors (MetS) was observed (3.1 vs. 2.06, p = 0.0008). An OR of 7.55 (p = 0.01) for the presence of HMOD was observed in subjects diagnosed with MetS.

Conclusions:
In our population, the presence of abdominal obesity may indicate a greater risk of developing HMOD (especially left ventricular hypertrophy and increased arterial stiffness) in essential hypertensive patients. WHtR may be a more sensitive indicator than WC. Furthermore, the significant increase in the risk of HMOD in the presence of MetS may indicate that the synergy between multiple risk factors correlates more strongly with the development of HMOD. Therefore, in the management of essential hypertension, it is of great importance to combine drug therapy with a strategy of reduction of abdominal adipose tissue and the other MetS factors.
ASTRAGALOSIDE IV IMPROVED OXIDATIVE STRESS INDUCED INJURY THROUGH PINK1/PARKIN-MEDIATED MITOPHAGY IN H9C2 CELLS
Authors: Miaomiao Qi , Sun Runmin , Wang Qiongying , Yu Jing 
Published: June 2023

Objective:
To explore the mechanisms of Astragaloside IV on improving the oxidative stress induced injury in H9c2 cells.

Design and method:
H9c2 cells were divided into normal control group (cultured without intervention), H2O2 model group (cultured with 200umol/L H2O2 for 2 hours), As-IV with H2O2 group (pretreated with 100umol/L As-IV for 1 hour, then incubated with H2O2 for 2 hours) and Mdivi-1 with H2O2 group (pretreated with 5umol/L Mdivi-1 for 1 hour, then incubated with H2O2 for 2 hours). The activity of lactate dehydrogenase (LDH) in cell culture medium was measured to evaluate the degree of oxidative damage of cells, and the protein levels of Bax, Bcl-2, Drp1, LC3, PINK1 and Parkin in each group were detected by Western blot. The statistical analysis of the experimental results was carried out by SPSS13.0 software.

Results:
1. Apoptosis of cells in each group: Compared with the normal control group, the expression of Bax in the H2O2 group increased (P<0.05), and the expression of Bcl-2 decreased [P<0.05]; compared with H2O2 group, the expression of Bax in As-IV group decreased (P<0.05), Bcl-2 The expression increased (P<0.05). 2. Oxidative stress damage of cells in each group: Compared with the normal control group, the LDH activity of cells in the H2O2 group increased, and compared with the H2O2 group Compared with that, the LDH activity of As-IV group decreased. 3. Mitochondrial dynamic expression: Compared with the normal control group, the expression of Drp1 in the H2O2 group increased; compared with the H2O2 group, the expression of Drp1 in the As-IV group and the Mdivi-1 group decreased. 4. The expression of mitophagy-related proteins in each group: Compared with the normal control group, the ratio of autophagy-related proteins LC3-II/LC3-I in the H2O2 group increased, and the expression of PINK1 increased (P<0.05), the expression of Parkin was significantly increased (P<0.05); compared with the H2O2 group, LC3-II/LC3-I in As-IV group and Mdivi-1 group decreased, the expression of PINK1 and Parkin proteins in As-IV group and Mdivi-1 group decreased .

Conclusions:
As-IV inhibited mitophagy through the PINK1/Parkin pathway, and alleviated oxidative stress induced injury in H9c2 cells.
BLOOD LEVELS OF INTERLEUKIN-17A IN PATIENTS WITH ARTERIAL HYPERTENSION AND ITS RELATIONSHIP WITH THE CHARACTERISTICS OF THE COURSE OF DISEASE
Authors: Koval Sergiy , Snihurska Irina , Starchenko Tetyana , Lytvynov Vadim , Penkova Marina , Mysnychenko Olga , Lytvynova Olga 
Published: June 2023

Objective:
One of the most important links in the pathogenesis of arterial hypertension (AH) is currently considered to be the activation of subclinical inflammation. Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by cells of the immune system, predominantly Th17 lymphocytes. The objective of the study was to evaluate the changes in blood levels of IL-17A in patients with AH and its relationship with the characteristics of the course of the disease.

Design and method:
The study involved 65 patients with grade 2-3 AH (34 men and 31 women aged 37 to 59 years) and 22 practically healthy individuals in the control group (12 men and 10 women aged 19 to 47 years). Patients were examined using standard clinical, laboratory and instrumental methods. The scope of the study also included the determination of blood levels of IL-17A and highly sensitive C-reactive protein (hsCRP) by the enzyme immunoassay. Examination of all patients and persons of the control group was carried out before the start of the war in Ukraine.

Results:
A significant increase in blood levels of IL-17A was established in general in the group of patients with 2-3 degree AH ((7.12 [4.74;10.67]) pg/mL, P <0.05) in comparison with practically healthy individuals ((3.24 [0,96;4,59]) pg/mL). The highest blood levels of IL-17A were found in patients with AH with a more pronounced increase in blood pressure (BP) up to the 3rd degree of AH ((9.87 [5.98;13.56]) pg/mL, P<0.05) compared with the levels of this factor in patients with 2nd degree of AH ((5.85 [3,66;8,12]) pg/mL). Significant positive correlations were found between blood levels of IL-17A and hsCRP (P = 0,023), left ventricular mass index (P = 0,027) and systolic BP (P = 0,036).

Conclusions:
In patients with grade 2-3 AH, a significant increase in blood levels of proinflammatory cytokine IL-17A and its relationship with indicators of activation of subclinical inflammation, the severity of hypertrophic remodeling of the heart, and the severity of hypertension were found.
THE EFFECT OF A DIGITAL HEALTH INTERVENTION ON PEOPLE WITH DIAGNOSED AND UNDIAGNOSED HYPERTENSION: A RETROSPECTIVE COHORT ANALYSIS
Authors: Ogboye Ayoposi , Munnee Maria Moosa , Ifeolu Ayanfe , Malumi Oluwaseyi , Mobisson Nneka 
Published: June 2023

Objective:
This study aims to show that a digital health intervention can help people with diagnosed or undiagnosed hypertension reduce their blood pressure and control their disease.

Design and method:
This retrospective study was conducted in January 2023 on people who reported a diagnosis of hypertension (self-reported group) or who logged in a systolic blood pressure of > = 140 mmHg or a diastolic blood pressure of > = 90 mmHg (undiagnosed group) who were enrolled on CompleteHealth™ between January and June 2022. CompleteHealth™ is a digital platform that allows members to access both a coach-led multidisciplinary care team and a platform for monitoring and tracking their health. The care team (comprising nutritionists, behavioural wellness coaches, and a fitness coach) engages with the members through an omnichannel approach. It provides regular digital nudges on monitoring their blood pressure, health education, and nutritional advice. The members work with their health coaches to create personalised action plans to achieve their health goals, e.g increased exercise, weight loss, and better diets.

Results:
1,203 people in both groups enrolled on CompleteHealth™ over the study period and entered a baseline and follow-up value for their blood pressure. 242 (20.12%) of these people self-reported a diagnosis of hypertension, while 961 (79.88%) presented with a baseline blood pressure of >140/90 mmHg. In the self-reported group, 93 people (38.43%) had controlled blood pressure at baseline, which rose to 150 (61.98%) at the end of the study. The group saw their average blood pressure fall from 149/95 mmHg to 131/85 mmHg at the end of the study. The undiagnosed group saw the number of people with controlled blood pressure rise from 68 (7.08%) to 695 (72.32%), while the average blood pressure of the group fell from 140/94 mmHg to 129/82 mmHg at the end of the study.

Conclusions:
While there is a need for further awareness about hypertension, especially to encourage testing and diagnosis, we have been able to show that the combination of a digital health intervention and virtual health coaching can help people who have hypertension or elevated blood pressure control their blood pressure.
COMPARISON OF FIRST RESULTS OF RADIOFREQUENCY RENAL DENERVATIONS WITH FIRST AND SECOND GENERATION TECHNIQUES
Authors: Légrády Péter , Fejes Imola , Schulcz Domonkos , Nagy Ferenc Tamás , Ungi Imre , Ruzsa Zoltán , Ábrahám György 
Published: June 2023

Objective:
A form of renal denervation, when using radiofrequency technique, thermal energy destroys the nerve-fibres around the renal artery. The Symplicity FlexTM was the first such catheter, an improved new generation version of it is the Symplicity SpyralTM catheter. In the Albert Szent-Györgyi Health Center of the University of Szeged, renal denervations were performed with both devices in hypertensive patients whose blood pressure could not be reduced to the goal range with multiple antihypertensive combinations.

Design and method:
With the first generation catheter, only the main branch was ablated at 4-5 points per side, and with the Symplicity SpyralTM catheter, even the segmental small branches together with the main branches were ablated at a total of at least 16-18 points per side.

Results:
With the old method after RDN, SBP decreased by 40 mmHg and DBP by 20 mmHg. The reduction was greatest 1 month after the intervention, 45 and 35 mm Hg. But did not reach the goal values. With new method after RDN, SBP decreased by 38 mmHg and DBP by 27 mmHg. The reduction was greatest 1 month after the intervention, 49 and 37 mm Hg. With the new the SBP was already in the target range after the intervention and remained there for 6 months. In addition, the number of antihypertensives could be significantly reduced. With the old method the goal BP value could not be achieved. Vascular complications did not occur in either case of interventions.

Conclusions:
Our first result with the Symplicity SpyralTM catheter according to the new concepts supports the view that more accurate ablation and preferably distal ablation can lead to more effective blood pressure reduction.
CHARACTERISTIC OF RESPONDERS TO RENAL DENERVATION - CROATIAN REAL-LIFE STUDY
Authors: Jelakovic Ana , Begic Zvonimir , Basic Matija , Barisic Klara , Perkov Drazen , Lovric Mila , Sarac Antonela , Dika Zivka , Stambuk Sandra Karanovic , Zivko Marijana , Josipovic Josipa , Ambramovic Ivana , Kacinari Patricia , Jelakovic Bojan 
Published: June 2023

Objective:
Heterogeneity in response to renal denervation (RDN) is acknowledged phenomena and one of most important tasks in this field is to find reliable predictive biomarker for positive response. Our aim was to analyse characteristics of resistant hypertensive patients who were responders 6 months after RDN.

Design and method:
Out of 31 truly resistant patients whom secondary forms of hypertension were ruled out and were enrolled into the Croatian Spyral RDN registry, 18 (10 m, 8 w, average age 49.3) were eligible for analyses. Office BP, ABPM, central BP and PWV were measured with Omron M6, Molbilograph and Sphygmocor devices, respectively. Sympathetic/parasympathetic activity was measured with ANX-3.0 ANSAR device.

Results:
Responders were 6.7 years older, less obese with at basal slightly higher eGFR (88.6 vs. 79.8), uric acid (406.5 vs. 376.4), salt intake (12.6 g/day vs.9.8 g/day) and had significantly higher basal office BP (169.5/99.7 vs. 153.3/96.5) as well as ABPM values. Central aortic systolic BP and Aix were higher in responders (154.5 vs, 147.1; 31.5 vs 27.3) without difference in PWV (10.1 vs. 9.6). Responders had lower values of PP amplification (1.22 vs. 1.33). Significantly higher basal sympathetic activity (LFa/RFa) was determined in responders than in non-responders (6.68 vs. 1.25).

Conclusions:
Responders were older with higher basal office BP, ABPM but also higher central BP and Aix with lower pulse pressure amplification. They ingested more salt, had higher values of uric acid and importantly had more exaggerated sympathetic activity. Whether some of identified parameters could be considered as a biomarker for positive response in resistant hypertensive patients should be determined in larger cohort of patients.
EFFECT OF RENAL DENERVATION ON THE PLASMA ADIPONECTIN CONCENTRATION IN PATIENTS WITH RESISTANT HYPERTENSION
Authors: Adamczak Marcin , Czerwienska Beata , Lelek Michal , Gojowy Damian , Surma Stanislaw , Mizia-Stec Katarzyna , Wiecek Andrzej 
Published: June 2023

Objective:
Adiponectin is produced by white adipose tissue and has anti-diabetic, anti-atherosclerotic, anti-thrombotic, anti-inflammatory, and cardioprotective properties. In patients with arterial hypertension plasma concentration of adiponectin is lower than in healthy subjects. Renal denervation (RDN) i.e. percutaneous ablation of fibers from the sympathetic nervous system located in the wall of the renal arteries by radio frequency waves, is a method of resistant arterial hypertension treatment. The aim of this single center, interventional, clinical study was to assess the effect of RDN on the plasma adiponectin concentration in patients with resistant arterial hypertension.

Design and method:
Twenty-six patients (12 women, 14 men) aged 54.0±7.8 years with resistant hypertension who underwent RDN using Simplicity catheters (Medtronic, Inc., Northridge, CA) were enrolled in the study. Plasma adiponectin concentration was determined using the Human Adiponectin ELISA Kit (Otsuka Pharmaceutical Co, Tokyo, Japan) before the RDN and 6 and 12 months after this procedure.

Results:
Blood pressure (BP) values before RDN and 6 and 12 months after RDN were as follow: systolic BP - 190.4±24.5, 160.8±14.5, 155.7±17.9 mmHg (p<0.001) and diastolic BP - 111.7±18.9, 88.9±8.3, 91.2±10.2 mmHg (p<0.001), respectively. Body mass index (BMI) before RDN, 6 and 12 months after RDN were 31.5±4.2, 30.5 ±4.4, 30.2±4.0 kg/m2, (p = 0.057), respectively. Plasma adiponectin concentration before the RDN and 6 and 12 months after RDN were 6.93±4.85, 7.94±3.97, 8.83±6.12 [μg/ml] (p = 0.007), respectively. In the follow up i.e. 6 and 12 months after RDN plasma adiponectin concentration increases significantly in responders (systolic BP decrease higher or equal 25 mmHg) (7.93±6.14, 8.87±4.68, 10.57±7.51 [μg/mL]; respectively]; p = 0.03, and did not change significantly in low-responders to RDN (systolic BP decrease < 25 mmHg) (5.76±2.45, 6.86±2.76, 6.81±3.19 [μg/mL]; respectively; p = 0.2).

Conclusions:
1. Plasma adiponectin concentration increases significantly after successful RDN in patients with resistant arterial hypertension. 2. Higher plasma adiponectin concentration may participate - beyond blood pressure reduction - in the cardiovascular benefits related to successful RDN, however clinical consequences of our results need further investigations.
FACTORS ASSOCIATED WITH DECREASED LONGITUDINAL FUNCTION IN RENAL FAILURE HYPERTENSIVE PATIENT
Authors: Bendiab Nabila Taleb , Nigassa Nawel Brikci , Bencheboub Izzeddine , Benkhedda Salim 
Published: June 2023

Objective:
Although the combination of arterial hypertension and renal insufficiency (RI) increases the risk of left ventricular (LV) dysfunction, the impact of renal insufficiency on LV geometry and subclinical dysfunction in hypertensive patients with normal ejection fraction (EF) has rarely been evaluated. The objective of this work is to study the correlation between renal failure and the early onset of hypertensive heart disease, as well as the determination of the associated factors influencing this subclinical heart attack.

Design and method:
A cross-sectional analytical study was carried out in 200 hypertensive patients recruited from the outpatient cardiology consultation, divided into: 100 patients with and 100 without concomitant renal failure.
Hypertensive patients with or without renal failure underwent cardiac echocardiography coupled with an evaluation of the global longitudinal deformity (GLS) of the LV

Results:
Among the 200 patients with hypertension (mean age 61.7 ± 8.5 years) and EF >55%, 100 had associated renal impairment. Patients with IR had more diabetes(60.5%vs. 36%, p = 0.002), higher BP levels (160±19/81±13 vs. 139±14/74±11, p = 0.000), higher VG mass index (116.05±31.1vs. 110.6±24.8g/m2, p = 0.007) andhigher relative wall thickness (0.46±0.08 vs. 0.44±0.07 p = 0.0001). They more frequently had concentric remodeling (28(28%) vs. 19(19%), p = 0.008), concentric hypertrophy (46(46%) vs. 38(38%), p<0.0001), pressures filling volumes (7.4±3.0vs. 6.0±2.1, p = 0.001), indexed left atrial volumes greater than 28 mL/m2 (18.8±8.1 vs.15.5±6.0, p = 0.004), and reduced GLS less than 18% (70% vs. 48%, p < 0.0001). After adjusting for BP and diabetes, IR remains an independent determinant of GLS decline (OR = 2.26, 95% CI 1.11–4.61, p = 0.023).

Conclusions:
Left ventricular geometry and subclinical LV function assessed with GLS are more impaired in hypertensive patients with renal failure. Preventive approaches to control the risk of onset of renal failure in hypertensive patients should be emphasized.
INVASIVE VALIDATION OF THE ANTARES ALGORITHM FOR ESTIMATING CENTRAL BLOOD PRESSURE IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Authors: Stäuber Alexander , Piper Cornelia , Eckert Siegfried , Richter Stefan , Dörr Marcus , Ohlow Marc-Alexander , Hoppe Matthias Wilhelm , Johannes Baulmann 
Published: June 2023

Objective:
Chronic kidney disease (CKD) is characterized by decreased renal autoregulatory capacity, increased proteinuria, and direct transmission of systemic blood pressure to the glomeruli. Thereby, an increase in central (aortic) blood pressure (cBP) accelerates the progression of CKD. Antares is a pulse wave analysis algorithm designed to allow a non-invasive estimation of cBP using automated oscillometric blood pressure devices. We aimed to compare the invasively measured cBP with the estimated cBP using the Antares algorithm in patients with CKD.

Design and method:
26 patients with stages 3-5 CKD (eGFR <60 ml/min/1.73m2, 88% stage 3 CKD, age 78±9 years, BMI 29±5 kg/m2, 65% male) were included and cBP was measured invasively during elective coronary angiography and simultaneously non-invasively using the custo screen 400 device (custo med GmbH, Ottobrunn, Germany) with the integrated Antares algorithm (Redwave Medical GmbH, Jena, Germany).

Results:
The mean difference for cBP was -0.7 ± 6.3 mmHg for central systolic BP (cSBP), -2.0 ± 5.1 mmHg for central mean arterial pressure (cMAP) and -4.2 ± 7.2 mmHg for central diastolic BP (cDBP). High correlations were found between estimated and invasively measured cBP (cSBP, r = 0.96; cMAP, r = 0.92; cDBP, r = 0.77; all p<0.001).

Conclusions:
The present study demonstrates that the Antares algorithm can estimate cBP with high accuracy in patients with CKD. Measurement of cBP and subsequent therapeutic interventions could improve renal and cardiovascular prognosis in these patients.