bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors and consequences of post-esophagectomy delirium: a systematic review and meta-analysis
Authors: Papaconstantinou Dimitrios , Frountzas Maximos , Ruurda Jelle P , Mantziari Stella , Tsilimigras Diamantis I , Koliakos Nikolaos , Tsivgoulis Georgios , Schizas Dimitrios 
Published: January 2023

Abstract
Post-operative delirium (POD) is a state of mental and neurocognitive impairment characterized by disorientation and fluctuating levels of consciousness. POD in the context of esophageal surgery may herald serious and potentially life-threatening post-operative complications, or conversely be a symptom of severe underlying pathophysiologic disturbances. The aim of the present systematic review and meta-analysis is to explore risk factors associated with the development of POD and assess its impact on post-operative outcomes. A systematic literature search of the MedLine, Web of Science, Embase and Cochrane CENTRAL databases and the clinicaltrials.gov registry was undertaken. A random-effects model was used for data synthesis with pooled outcomes expressed as Odds Ratios (OR), or standardized mean differences (WMD) with corresponding 95% Confidence Intervals. Seven studies incorporating 2449 patients (556 with POD and 1893 without POD) were identified. Patients experiencing POD were older (WMD 0.29 ± 0.13 years, P &lt; 0.001), with higher Charlson’s Comorbidity Index (CCI; WMD 0.31 ± 0.23, P = 0.007) and were significantly more likely to be smokers (OR 1.38, 95% CI 1.07–1.77, P = 0.01). Additionally, POD was associated with blood transfusions (OR 2.08, 95% CI 1.56–2.77, P &lt; 0.001), and a significantly increased likelihood to develop anastomotic leak (OR 2.03, 95% CI 1.25–3.29, P = 0.004). Finally, POD was associated with increased mortality (OR 2.71, 95% CI 1.24–5.93, P = 0.01) and longer hospital stay (WMD 0.4 ± 0.24, P = 0.001). These findings highlight the clinical relevance and possible economic impact of POD after esophagectomy for malignant disease and emphasize the need of developing effective preventive strategies.
GATA6-AS1 Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis
Authors: Sosnovski Katya E , Braun Tzipi , Amir Amnon , Moshel Danielle , BenShoshan Marina , VanDussen Kelli L , Levhar Nina , Abbas-Egbariya Haya , Beider Katia , Ben-Yishay Rakefet , Asad Ali Syed , Moore Sean R , Kugathasan Subra , Abramovich Ifat , Glick Saar Efrat , Weiss Batya , Barshack Iris , Gottlieb Eyal , Geiger Tamar , Ben-Horin Shomron , Ulitsky Igor , Hyams Jeffrey S , Denson Lee A , Haberman Yael 
Published: January 2023

Abstract

Background and Aims
Widespread dysregulation of long non-coding RNAs [lncRNAs] including a reduction in GATA6-AS1 was noted in inflammatory bowel disease [IBD]. We previously reported a prominent inhibition of epithelial mitochondrial functions in ulcerative colitis [UC]. However, the connection between reduction of GATA6-AS1 expression and attenuated epithelial mitochondrial functions was not defined.

Methods
Mucosal transcriptomics was used to conform GATA6-AS1 reduction in several treatment-naïve independent human cohorts [n=673]. RNA pull-down followed by mass spectrometry was used to determine the GATA6-AS1 interactome. Metabolomics and mitochondrial respiration following GATA6-AS1 silencing in Caco-2 cells were used to elaborate on GATA6-AS1 functions.

Results
GATA6-AS1 showed predominant expression in gut epithelia using single cell datasets. GATA6-AS1 levels were reduced in Crohn’s disease [CD] ileum and UC rectum in independent cohorts. Reduced GATA6-AS1 lncRNA was further linked to a more severe UC form, and to a less favourable UC course. The GATA6-AS1 interactome showed robust enrichment for mitochondrial proteins, and included TGM2, an autoantigen in coeliac disease that is induced in UC, CD and coeliac disease, in contrast to GATA6-AS1 reduction in these cohorts. GATA6-AS1 silencing resulted in induction of TGM2, and this was coupled with a reduction in mitochondrial membrane potential and mitochondrial respiration, as well as in a reduction of metabolites linked to aerobic respiration relevant to mucosal inflammation. TGM2 knockdown in GATA6-AS1-deficient cells rescued mitochondrial respiration.

Conclusions
GATA6-AS1 levels are reduced in UC, CD and coeliac disease, and in more severe UC forms. We highlight GATA6-AS1 as a target regulating epithelial mitochondrial functions, potentially through controlling TGM2 levels.
Dialysis catheter-related sepsis resulted in infective endocarditis, septic pulmonary embolism and acute inferolateral STEMI: a case report
Authors: Ahmed Islam Abdelmoneim , Asiri Abdullah Ali , Attia Mohamed , Alshehri Saleh 
Published: January 2023

Abstract

Background
Embolic myocardial infarction is an uncommon but increasingly recognized complication of infective endocarditis (IE). Although the incidence is low and ranges from 1% to 10%, the mortality rate is high (64%). The characteristics of septic embolism on presentation are nonspecific and usually are unrecognized by clinicians. This case report aims to build a high index of suspicion among clinicians for IE presenting with the complication of embolic myocardial infarction especially in patients with indwelling venous catheters.

Case Summary
A 62-year-old woman with end-stage renal disease on haemodialysis presented with shortness of breath and desaturation. Her history was significant for end-stage renal disease managed with regular haemodialysis by a right-sided double-lumen tunnelled catheter. An initial diagnosis was made of pulmonary embolism, and management with intravenous heparin was initiated. She subsequently developed inferolateral ST-elevation myocardial infarction, and treatment with percutaneous coronary intervention to the posterior descending artery failed. Then, the patient developed complete heart block, aortic valve vegetation, acute severe aortic regurgitation, and shock.

Discussion
Acute coronary syndrome is usually an early and uncommon complication of IE and the risk of embolism decreases after antibiotic therapy is initiated. Due to the low incidence of coronary events in IE, only case reports have been published. Most patients with septic pulmonary embolism have a presentation similar to that for pneumonia. The diagnosis is therefore often delayed, which consequently influences prognosis. Our case report presents an example of IE-related multiple systemic embolization with poor patient outcome due to delayed diagnosis.
Cardiac rehabilitation, physical activity, and the effectiveness of activity monitoring devices on cardiovascular patients: an umbrella review of systematic reviews
Authors: Dafny Hila Ariela , Champion Stephanie , Gebremichael Lemlem G , Pearson Vincent , Hendriks Jeroen M , Clark Robyn A , Pinero de Plaza Maria Alejandra , Gulyani Aarti , Hines Sonia , Beleigoli Alline 
Published: January 2023

Abstract

Aims
To consolidate the evidence on the effectiveness of activity-monitoring devices and mobile applications on physical activity and health outcomes of patients with cardiovascular disease who attended cardiac rehabilitation (CR) programmes.

Methods and results
An umbrella review of published randomized controlled trials, systematic reviews, and meta-analyses was conducted. Nine databases were searched from inception to 9 February 2022. Search and data extraction followed the JBI methodology for umbrella reviews and PRISMA guidelines. Nine systematic reviews met the inclusion criteria, comparing outcomes of participants in CR programmes utilizing devices/applications, to patients without access to CR with devices/applications. A wide range of physical, clinical, and behavioural outcomes were reported, with results from 18 712 participants. Meta-analyses reported improvements in physical activity, minutes/week [standardized mean difference (SMD) 0.23, 95% confidence interval (CI) 0.10–0.35] and activity levels (SMD 0.29, 95% CI 0.07–0.51), and a reduction in sedentariness [risk ratio (RR) 0.54, 95% CI 0.39–0.75] in CR participants, compared with usual care. Of clinical outcomes, the risk of re-hospitalization reduced significantly (RR 0.49, 95% CI 0.27–0.89), and there was reduction (non-significant) in mortality (RR 0.27, 95% CI 0.05–1.54). From the behavioural outcomes, reviews reported improvements in smoking behaviour (RR 0.87, 95% CI 0.67–1.13) and total diet quality intake (RR 0.79, 95% CI 0.66–0.94) among CR patients.

Conclusions
The use of devices/applications was associated with increase in activity, healthy behaviours, and reductions in clinical indicators. Although most effect sizes indicate limited clinical benefits, the broad consistency of the narrative suggests devices/applications are effective at improving CR patients’ outcomes.
Recombinant or endogenous thyroid-stimulating hormone for radioactive iodine therapy in thyroid cancer: state of knowledge and current controversies
Authors: Coerts Hannelore I , de Keizer Bart , Marlowe Robert J , Verburg Frederik A 
Published: January 2023

Abstract
For patients undergoing radioiodine therapy (RIT) of differentiated thyroid carcinoma (DTC), thyroid-stimulating hormone (TSH) stimulation prior to RIT can be achieved using thyroid hormone withdrawal (THW) or administration of recombinant human TSH (rhTSH). As THW can lead to nausea, headaches, vomiting, fatigue, and dizziness secondary to transient acute hypothyroidism, rhTSH could be a good alternative. Recombinant human TSH has been administered in patients in order to stimulate TSH for RIT since 2005. According to the Martinique criteria formulated by the leading professional societies involved in care of patients with DTC, rhTSH can be applied in 3 settings: for remnant ablation, adjuvant treatment, and treatment of known disease. Numerous studies have investigated the effects of rhTSH as a method of TSH stimulation on the thyroid cell, the systemic effects, biokinetics, and clinical outcomes; however, no consensus has been reached about many aspects of its potential use. Recombinant human TSH is able to stimulate sufficient TSH levels (&gt;30 mIU L–1) and is hypothesized to decrease risks of tumor cell proliferation. As rhTSH-use avoids the transiently impaired renal function associated with THW, radioiodine excretion is faster with the former, leading to a lower iodine-131 uptake and a difference in fractional remnant uptake, effective half-life, mean residence time, and dose to the blood. Differences between rhTSH and THW were observed in radioiodine genotoxic effects and endothelial-dependent vasodilation and inflammation. For thyroid remnant ablation, THW and rhTSH lead to similar remnant ablation rates. For adjuvant therapy and treatment of known disease, insufficient trials have been conducted and future prospective studies are recommended. The current review provides a state-of-the-science overview on the issues and debates surrounding TSH stimulation through either rhTSH adminsitration orendogenous TSH production after levothyroxin withdrawal.
What do spontaneous coronary artery dissection survivors want to support their recovery? a qualitative study
Authors: Binnie Kirsten , Neubeck Lis , McHale Sheona , Hanson Coral L 
Published: January 2023

Abstract

Aims
Spontaneous coronary artery dissection (SCAD) is increasingly recognized as an important cause of myocardial infarction predominantly affecting women aged younger than 50 years. There is limited research addressing female and male SCAD survivors’ experience of, or requirements for, support post-SCAD. This study explored what SCAD survivors wanted to support recovery.

Methods and results
A qualitative study using semi-structured video and telephone interviews. Data were analysed through thematic analysis using the framework approach. We interviewed 20 participants (19 females) with a mean age of 54.6 (+/-SD 8.5 years). Three overarching themes encapsulated participants’ views about support requirements. (i) Education and information. Participants thought healthcare professionals involved in diagnosis and supporting recovery required greater awareness of SCAD and the psychological effect of SCAD. They wanted accessible SCAD information immediately post-event and during the educational component of cardiac rehabilitation. (ii) Physical activity. Requirements were for advice tailored to individuals’ specific needs, physical capabilities, and physical activity preferences. Participants suggested that utilizing wearable technology was helpful to encourage a safe return to activity. (iii) Psychosocial support. Participants wanted formal psychosocial support immediately post-event, during cardiac rehabilitation and in the longer term.

Conclusion
Better healthcare professional training may improve diagnosis, and increase support and awareness of SCAD. SCAD support programmes should provide early SCAD specific education utilizing online sources, individually tailor physical activity prescription, offer wearable technology to support a return to being active, and provide short- and long-term psychosocial support. As SCAD is predominately a female condition, programmes should consider female physical activity preferences.
Effects of the dual inoculation of dark septate endophytes and Trichoderma koningiopsis on blueberry growth and rhizosphere soil microorganisms
Authors: Li Si , Shang Xiao-Jing , Luo Qi-Xing , Yan Qian , Hou Rui 
Published: January 2023

Abstract
Blueberry is a shallow root plant in which the absorption of nutrients is inefficient, resulting in slow growth under artificial cultivation conditions. Endophytes play an important role in promoting plant growth; however, the effects of Trichoderma spp. and dark septate endophytes (DSEs) on host plant growth and soil microorganisms are still debatable. We isolated two endophytic fungal species, Trichoderma koningiopsis (TK) and a DSE (Amesia nigricolor; AN), from blueberry roots, which can solubilize insoluble phosphorus and produce amylase and cellulase to promote plant growth. We found that under dual inoculation, the colonization rate and colonization intensity of TK were higher than they were under single inoculation with TK, while the colonization rate and colonization intensity of AN were lower under dual inoculation than under single inoculation with AN. The plant nutrients, root activity, available potassium, and parts of soil phosphatase activities were highest under dual inoculation. TK inoculation resulted in the highest diversity and richness in the soil fungi and bacteria, followed by dual inoculation. The abundance of Ascomycota, Acidobacteriae, Firmicutes, and Actinobacteriota increased significantly, resulting in Trichoderma and Vicinamibacteria inoculated with TK, Chaetomium and Alicyclobacillales inoculated with AN, and Hypocreales and Burkholderiaceae with dual inoculation enriched in the soil.
Revealing the Permanent and Transient Plant Understory in Gallery Forests in the Cerrado of Central Brazil
Authors: Tavora Ana Carolina , Carvalho-Silva Micheline , Amaral Eliel de Jesus , Cupertino-Eisenlohr Mônica A , Nogueira Eloisa V , Munhoz Cássia Beatriz R 
Published: January 2023

Abstract
The understories of tropical forests comprise complex communities and can be divided into permanent understory, where the generally shade-tolerant plant growth forms are less developed in height, and transient understory, where young tree individuals are only temporarily present. Despite a high contribution to species richness in tropical forests, the understory is poorly studied. Here, we examined the species composition, richness, structure, diversity, and the relative contribution of growth forms in permanent and transient understories of gallery forests in the Brazilian Cerrado. A total of 211 species distributed into sixty-seven families and 153 genera were sampled. The most species-rich family was Rubiaceae, and Miconia was the genus with the highest species richness. The species Hildaea pallens had the highest importance in the forests. The best-represented growth forms were tree seedlings, followed by shrubs and lianas. The transient component of the understory in gallery forests was the most diverse. However, in terms of species relative cover, both transient and permanent understory species contributed equally to the understory structure, mainly due to the high cover of Poaceae species. Our study is the first to examine composition, structure, diversity, and growth forms in the permanent and transient understories of gallery forests.
Study Implications: Our study is innovative in describing the plant community attributes of gallery forest understories in the Brazilian Cerrado. The understories of tropical forests comprise complex communities and can be divided into permanent and transient understory. The transient component of the understory in gallery forests was the most diverse, represented by seedlings and young tree specimens. However, in terms of species relative cover, both transient and permanent understory species contributed equally to the understory structure. Here, we provide evidence that may be useful to initiatives seeking to conduct ecological restoration and conservation of gallery forests in the Cerrado.
SPR-1/CoREST facilitates the maternal epigenetic reprogramming of the histone demethylase SPR-5/LSD1
Authors: Carpenter Brandon S , Scott Alyssa , Goldin Robert , Chavez Sindy R , Rodriguez Juan D , Myrick Dexter A , Curlee Marcus , Schmeichel Karen L , Katz David J 
Published: January 2023

Abstract
Maternal reprogramming of histone methylation is critical for reestablishing totipotency in the zygote, but how histone-modifying enzymes are regulated during maternal reprogramming is not well characterized. To address this gap, we asked whether maternal reprogramming by the H3K4me1/2 demethylase SPR-5/LSD1/KDM1A, is regulated by the chromatin co-repressor protein, SPR-1/CoREST, in Caenorhabditis elegans and mice. In C. elegans, SPR-5 functions as part of a reprogramming switch together with the H3K9 methyltransferase MET-2. By examining germline development, fertility, and gene expression in double mutants between spr-1 and met-2, as well as fertility in double mutants between spr-1 and spr-5, we find that loss of SPR-1 results in a partial loss of SPR-5 maternal reprogramming function. In mice, we generated a separation of function Lsd1 M448V point mutation that compromises CoREST binding, but only slightly affects LSD1 demethylase activity. When maternal LSD1 in the oocyte is derived exclusively from this allele, the progeny phenocopy the increased perinatal lethality that we previously observed when LSD1 was reduced maternally. Together, these data are consistent with CoREST having a conserved function in facilitating maternal LSD1 epigenetic reprogramming.
Theorizing “Place” in Aging in Place: The Need for Territorial and Relational Perspectives
Authors: Yarker Sophie , Doran Patty , Buffel Tine 
Published: January 2023

Abstract
This paper argues for a greater theorization of “place” within aging-in-place research. It extends calls for a relational conceptualization of place by demonstrating the need for aging-in-place researchers to also pay greater attention to territorial aspects of place. This complementary understanding will help establish a new spatial grammar within aging-in-place research, that not only would improve conceptual clarity to aging in place, but would also support a more critical engagement of aging in place in questions of inequality. The paper demonstrates this through a discussion of 2 forms of inequality pertinent to older people: the uneven capacity of places to support older people and experiences of social exclusion in relation to place attachment for older people from marginalized groups.
A Cautionary Tale: examples of the mis-location of small earthquakes beneath the Tibetan plateau by routine approaches
Authors: Craig Timothy J , Jackson James , Priestley Keith , Ekström Göran 
Published: January 2023

SUMMARYEarthquake moment tensors and centroid locations in the catalogue of the Global CMT (gCMT) project, formerly the Harvard CMT project, have become an essential resource for studying active global tectonics, used by many solid-Earth researchers. The catalogue’s quality, long duration (1976–present), ease of access and global coverage of earthquakes larger than about Mw 5.5 have transformed our ability to study regional patterns of earthquake locations and focal mechanisms. It also allows researchers to easily identify earthquakes with anomalous mechanisms and depths that stand out from the global or regional patterns, some of which require us to look more closely at accepted interpretations of geodynamics, tectonics or rheology. But, as in all catalogues that are, to some extent and necessarily, produced in a semi-routine fashion, the catalogue may contain anomalies that are in fact errors. Thus, before re-assessing geodynamic, tectonic or rheological understanding on the basis of anomalous earthquake locations or mechanisms in the gCMT catalogue, it is first prudent to check those anomalies are real. The purpose of this paper is to illustrate that necessity in the eastern Himalayas and SE Tibet, where two earthquakes that would otherwise require a radical revision of current geodynamic understanding are shown, in fact, to have gCMT depths (and, in one case, also focal mechanism) that are incorrect.
Review of surgical experience in 188 infants and young children with Ebstein anomaly
Authors: Liu Wei , Wen Chen , Shentu Jin , Ma Ruixiang , Zhang Hao , Zhu Zhongqun , Shi Guocheng , Chen Huiwen 
Published: January 2023

AbstractOBJECTIVESThis study sought to review our single-institutional surgical experience in paediatric Ebstein anomaly (EA).METHODSWe retrospectively reviewed the paediatric patients with EA undergoing operation between 2004 and 2020. The time-to-event analysis was studied using Kaplan–Meier estimates. Cox regression model was used to identify risk factors for recurrent moderate–severe or greater tricuspid regurgitation (TR).RESULTSA total of 188 patients at a median age of 3.0 [interquartile range (IQR), 1.6–5.6] years were included, among whom 108 (57.4%) underwent cone reconstruction (CR). Bidirectional cavopulmonary shunt was required in 53 patients (28.2%). There were no in-hospital deaths. The median follow-up time was 5.6 (IQR, 2.9–8.9) years. Twenty-three (12.2%) developed recurrent moderate–severe or greater TR, among whom 9 required reoperation and 1 had late death. There was a lower incidence of recurrent TR (P = 0.006) and reoperation for TR (P = 0.037) in the CR group compared with the non-CR group. There was no difference in the incidence of recurrent TR (P = 0.61), reoperation (P = 0.9) and death (P = 0.48) among patients aged &lt;1, 1–4 and 4–18 years.CONCLUSIONSAcceptable outcomes can be anticipated in paediatric EA undergoing CR in terms of freedom from TR of &gt; moderate degree at a mid-term follow-up.