bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative identification of hub genes in development of atrial fibrillation related stroke
Authors: Huang Kai , Fan Xi , Jiang Yuwen , Jin Sheng , Huang Jiechun , Pang Liewen , Wang Yiqing , Wu Yuming , Sun Xiaotian 
Published: March 2023

Background
As the most common arrhythmia, atrial fibrillation (AF) is associated with a significantly increased risk of stroke, which causes high disability and mortality. To date, the underlying mechanism of stroke occurring after AF remains unclear. Herein, we studied hub genes and regulatory pathways involved in AF and secondary stroke and aimed to reveal biomarkers and therapeutic targets of AF-related stroke.

Methods
The GSE79768 and GSE58294 datasets were used to analyze AF- and stroke-related differentially expressed genes (DEGs) to obtain a DEG1 dataset. Weighted correlation network analysis (WGCNA) was used to identify modules associated with AF-related stroke in GSE66724 (DEG2). DEG1 and DEG2 were merged, and hub genes were identified based on protein–protein interaction networks. Gene Ontology terms were used to analyze the enriched pathways. The GSE129409 and GSE70887 were applied to construct a circRNA-miRNA-mRNA network in AF-related stroke. Hub genes were verified in patients using quantitative real-time polymerase chain reaction (qRT-PCR).

Results
We identified 3,132 DEGs in blood samples and 253 DEGs in left atrial specimens. Co-expressed hub genes of EIF4E3, ZNF595, ZNF700, MATR3, ACKR4, ANXA3, SEPSECS-AS1, and RNF166 were significantly associated with AF-related stroke. The hsa_circ_0018657/hsa-miR-198/EIF4E3 pathway was explored as the regulating axis in AF-related stroke. The qRT-PCR results were consistent with the bioinformatic analysis.

Conclusions
Hub genes EIF4E3, ZNF595, ZNF700, MATR3, ACKR4, ANXA3, SEPSECS-AS1, and RNF166 have potential as novel biomarkers and therapeutic targets in AF-related stroke. The hsa_circ_0018657/hsa-miR-198/EIF4E3 axis could play an important role regulating the development of AF-related stroke.
The Politics of Public Broadcasting in Britain and Japan: The BBC and NHK Compared, Henry Laurence (2023)
Authors: Scarlata Alexa 
Published: March 2023

Review of: The Politics of Public Broadcasting in Britain and Japan: The BBC and NHK Compared, Henry Laurence (2023)
London and New York: Routledge, 236 pp.,
ISBN 978-1-03231-038-1, h/bk, USD 170.00
Correlation analysis of physical and mechanical parameters of inland fluvial-lacustrine soft soil based on different survey techniques
Authors: Zhang Liujun , Qiu Youqiang , Wu Tong , Zhang Wei 
Published: March 2023

Abstract
Based on the collected soil property index test data of more than 2,500 groups of inland fluvial-lacustrine soft soil, the correlation of physical and mechanical parameters of this soft soil was systematically analyzed. The results show that the physical indexes of inland fluvial-lacustrine soft soil are close to that of marine soft soil, while its mechanical indexes are higher. However, the variation coefficient of its mechanical indexes is much larger than that of the physical indexes. In addition, it is found that the cone penetration parameters of this soft soil are significantly correlated with its physical and mechanical indexes by establishing a series of empirical relationships between the static point resistance and the natural unit weight, the liquidity index, the quick shear cohesion, and vane shear strength. On the basis of the previous research results, the disturbance strength of inland fluvial-lacustrine soft soil can be converted into in situ strength by deriving the theoretical formula between the vane shear strength and the disturbance degree. The calculation process of the above conversion relation is explained in detail through an engineering case, which indicates that the theoretical formulas have good applicability for inland fluvial-lacustrine soft soil.
SARS-CoV-2 specific T-cell humoral response assessment after COVID-19 vaccination using a rapid direct real-time PCR amplification
Authors: Cosma Chiara , Galla Luisa , Padoan Andrea , Furlan Giulia , Marchioro Lucio , Zaninotto Martina , Basso Daniela , Plebani Mario 
Published: March 2023

Abstract

Objectives
The SARS-CoV-2 immune response is mediated by both humoral and cellular immunity. In this study, SARS-CoV-2 specific cellular immunity was tested by a novel direct real-time PCR (dRT-PCR) assay, targeting mRNA of CXCL10, and compared with respect to an ELISA measuring interferon gamma (IFN-γ) release.

Methods
Whole blood (Li–He) and serum samples were collected from 92 healthcare workers (HCW), with three doses of homologous (Pfizer/BioNTech, n=74) or heterologous (Pfizer/BioNTech and Vaxzevria or Moderna, n=18) vaccinations. Li–He samples were incubated with SCV2 PANEL-1-T-ACTIVATION (Hyris srl, Lodi, Italy), or CoV-2 IGRA TUBE ELISA (Euroimmune, Lubeck, Germany). CXCL10 mRNA expression was analyzed by bCube/bApp (Hyris), while IFN-γ was evaluated by quant-T-Cell SARS-CoV-2 ELISA (Euroimmune). Anti-SARS-CoV-2 S-RBD IgG levels were measured in sera using a CLIA assay (Snibe, Shenzen, China).

Results
Imprecision of dRT-PCR assay was found to be satisfactory, and the two methods for measuring T cell immunity to SARS-CoV-2 peptides agreed in 82/87 (94.2%) of results. At qualitative dRT-PCR analyses, 81 subjects (93.2%) resulted as reactive to SARS-CoV-2 peptides, 3 (3.4%) were borderline and 3 were negative (3.4%). At univariate and multivariate analyses of quantitative dRT-PCR mRNA of CXCL10 and IFN-γ release results showed no difference between HCW with previous infection, homologous/heterologous vaccination, or demographical features. Anti-SARS-CoV-2 S-RBD IgG was associated with the previous infection and the time between the last vaccination or positivity.

Conclusions
Direct RT-PCR appeared accurate for determining the presence or absence of immunoreactivity of SARS-CoV-2 specific T cells, especially when rapid analyses are required, such as for organ transplantation.
Microwave and Cs+-assisted chemo selective reaction protocol for synthesizing 2-styryl quinoline biorelevant molecules
Authors: Mittal Ravi Kumar , Purohit Priyank , Abdellattif Magda H. , Aggarwal Meenu 
Published: March 2023

Abstract
The reaction protocols and their continuous development to achieve the desired selectivity remain a primary target of organic chemistry, which is addressed here with the specific role of the cesium ion. The pharmacophore “2-styryl quinoline” was taken as a reference here because of the continuation of our work, where it was found fit as fusion inhibitors and anti-viral agents. The present protocol defines its importance for the synthesis of O-alkylated products. However, in most cases, N-alkylation proceeds because of nitrogen atoms’ more nucleophilic nature and electronic density. The cesium effect makes this possible because of the large cationic size and its affection for the oxygen atom. The plausible mechanism and its progression were demonstrated here with the help of density function theory calculation by analyzing the energy of intermediates. The protocol is also found suitable with microwave irradiation. Moreover, it gives the product a better yield in less reaction time. The present reaction protocol and its importance will address some of the crucial issues related to the synthesis of the complex molecule, and the present protocol will open up hope, where the selectivity and product yield would be a concern.
Supporting Humanitarian Crisis Decision Making with Reliable Intelligence Derived from Social Media Using AI
Authors: Garcia Christopher , Rabadi Ghaith , Abujaber Dia , Seck Mamadou 
Published: March 2023

Abstract
Recent advances in the field of artificial intelligence bring promising new capabilities that can substantially improve our ability to manage complex and evolving situations in the face of uncertainty. Humanitarian crises exemplify such situations, and the pervasiveness of social media renders it one of the most abundant sources of real-time information available. However, it is quite a difficult task to condense a body of social media posts into useful information quickly. In this paper we consider the challenge of using social media reports to provide a reliable, real-time situational awareness in the management of humanitarian crises. Effectively addressing this challenge requires extracting only the relevant information out of text and images in individual social media posts, fusing this information together into actionable information points for decision makers, and providing an assessment of the trustworthiness of this information. We propose a general solution framework and discuss a system developed in collaboration with NATO which combines state-of-the-art deep learning, natural language processing, computer vision, and information fusion models to provide a reliable, actionable, real-time situational awareness for supporting decision making in humanitarian crisis logistics. In addition to the technical approach, we also discuss important practical aspects of this project including the development and validation process, challenges encountered along the way, and key lessons learned.
Simulative study of vertical cavity with distributed feedback optical sources coupling to fiber systems evaluation
Authors: Rashed Ahmed Nabih Zaki , Reddy Mittamidi Madhusudhan , Nagendram Sanam , Anwer Twana Mohammed Kak , Ahammad Shaik Hasane , Hossain Md. Amzad , Shetea Eslam Fahmy 
Published: March 2023

Abstract
This paper has demonstrated the simulative study of vertical cavity with distributed feedback light sources coupling to the fiber systems. The simulative study of piezoresistive, capacitive and piezoelectric sensing for micro electro mechanical system has been clarified. The span against the diaphragm thickness for the square diaphragm, round diaphragm, a round bossed diaphragm and rectangular diaphragm is clarified. Acceleration against displacement for a capacitive accelerometer for step signal based on signal sided and double sided is reported. Besides, acceleration against max pulse time for a capacitive accelerometer is outlined. The frequency response plot for a piezoelectric accelerometer under longitudinal load and for thin film based piezoelectric accelerometer is demonstrated based on MEMSolver simulation software version 3.3.
Effects of the Strong Hearts program after a major cardiovascular event in patients with cardiovascular disease
Authors: Murphy Bruce E. , Card Peyton D. , Ramirez-Kelly Leybi , Xaysuda Amanda M. , Heidel R. Eric 
Published: March 2023

Abstract

Context
Cardiac rehabilitation (CR) and intensive cardiac rehabilitation (ICR) are secondary prevention interventions for cardiovascular disease (CVD) with a class 1a indication yet suboptimal utilization. To date, there are only three approved ICR programs. Alternative programing should be explored to increase enrollment and adherence in these interventions.

Objectives
This study aims to evaluate the effectiveness of the Strong Hearts program in cardiovascular patients following a major cardiovascular event.

Methods
One hundred ninety-seven (n = 197) participants were enrolled in this prospective, nonrandomized study. Patients were eligible for participation if they were referred by a physician after a major cardiovascular event, defined as any of the following: (1) acute myocardial infarction (MI) within the preceding 12 months; (2) current stable or unstable angina pectoris; (3) heart valve procedure; (4) percutaneous intervention of any kind; (5) heart transplant; (6) coronary artery bypass grafting (CABG); or (7) congestive heart failure (CHF) with reduced or preserved ejection fraction. Participants were asked to attend program visits four times per week for 9 weeks. Visits consisted of individualized exercise and intensive healthy lifestyle education. Paired t tests were utilized to compare pre- and postprogram outcome measures.

Results
One hundred twenty-eight (n = 128) participants completed the program within the 9-week time frame and their outcome measures were included in the data analysis. Among this, 35.2% participants were female and 64.8% were male. The mean age was 65 (range, 19-88). Qualifying diagnoses were percutaneous coronary intervention (PCI; 60, 46.9%), CABG (33, 25.8%), angina (24, 18.8%), valve procedures (8, 6.2%), and CHF (3, 2.3%). After implementation of the intervention, statistically significant decreases in weight (P < .001), body mass index (BMI, P < .001), waist circumference (P < .001), triglycerides (P = .01), systolic blood pressure (SBP, P <.001), diastolic blood pressure (DBP, P = .002), total fat mass (P < .001), Dartmouth Quality of Life Index P < .001), and cardiac depression scores (P = .044) were detected. In other instances, there were statistically significant increases across time for the clinical parameters of high-density lipoprotein (HDL, P = .02), Vitamin D (P = .001), metabolic equivalents (METS, P < .001), Duke activity scores (P < .001), and Rate Your Plate nutrition scores (P < .001). There were no significant changes across time for total cholesterol (P = .17), low-density lipoprotein (LDL, P = .21), A1c (P = .27), or dual-energy X-ray absorptiometry (DXA) total lean mass (P = .86).

Conclusions
The 9-week structured program resulted in significant cardiovascular benefit to patients with CVD by reducing cardiac risk factors, increasing exercise capacity, and improving quality of life.
Effect of minimal length uncertainty on neutrino oscillation
Authors: Twagirayezu Fidele J. 
Published: March 2023

Abstract
In this paper, we study the effect of the minimal length on neutrino oscillation in a static magnetic field. In the framework of the generalized uncertainty principle, we reformulate the Hamiltonian for a relativistic neutrino moving in a magnetic field oriented along the z-direction of Cartesian coordinates. Using the modified energy spectrum, we obtain the oscillation probability for different neutrino flavors. In addition, we obtain the energy differences for the neutrino-mass eigenstates. We find that the energy and energy difference depend on the minimal length parameter α, and the energy difference becomes independent of α when the magnetic field is not present. In addition, we find that the modified probability of oscillation differs from the usual probability of oscillation if a magnetic field is present. Using the current experimental result, we estimate the upper bound on the deformation parameter and the minimal length, and find that the upper bound on the minimal length scale is less than the electroweak scale. If the minimal length is at Planck scale, the minimal length formalism leads to the same result as a quantum theory of gravity with an

S
U

2

L

⊗
U

1

$SU{\left(2\right)}_{L}\otimes U\left(1\right)$

effective invariant dimension-5 Lagrangian including neutrino and Higgs fields.
Load-Specific Performance Fatigability, Coactivation, and Neuromuscular Responses to Fatiguing Forearm Flexion Muscle Actions in Women
Authors: Benitez Brian , Dinyer-McNeely Taylor K. , McCallum Lindsay , Kwak Minyoung , Succi Pasquale J. , Bergstrom Haley C. 
Published: March 2023

Abstract
Benitez, B, Dinyer-McNeeley, TK, McCallum, L, Kwak, M, Succi, PJ, and Bergstrom, HC. Load-specific performance fatigability, coactivation, and neuromuscular responses to fatiguing forearm flexion muscle actions in women. J Strength Cond Res 37(4): 769–779, 2023—This study examined the effects of fatiguing, bilateral, dynamic constant external resistance (DCER) forearm flexion on performance fatigability, coactivation, and neuromuscular responses of the biceps brachii (BB) and triceps brachii (TB) at high (80% 1 repetition maximum [1RM]) and low (30% 1RM) relative loads in women. Ten women completed 1RM testing and repetitions to failure (RTF) at 30 and 80% 1RM. Maximal voluntary isometric force was measured before and after RTF. Electromyographic (EMG) and mechanomyographic (MMG) amplitude (AMP) and mean power frequency (MPF) signals were measured from the BB and TB. Performance fatigability was greater (p < 0.05) after RTF at 30% (%∆ = 41.56 ± 18.61%) than 80% (%∆ = 19.65 ± 8.47%) 1RM. There was an increase in the coactivation ratio (less coactivation) between the initial and final repetitions at 30%, which may reflect greater increases in agonist muscle excitation (EMG AMP) relative to the antagonist for RTF at 30% than 80% 1RM. The initial repetitions EMG AMP was greater for 80% than 30% 1RM, but there was no difference between loads for the final repetitions. For both loads, there were increases in EMG MPF and MMG AMP and decreases in MMG MPF that may suggest fatigue-dependent recruitment of higher-threshold motor units. Thus, RTF at 30 and 80% 1RM during DCER forearm flexion may not necessitate additional muscle excitation to the antagonist muscle despite greater fatigability after RTF at 30% 1RM. These specific acute performance and neuromuscular responses may provide insight into the unique mechanism underlying adaptations to training performed at varying relative loads.
Using Neutron Radiography to Assess Parameters Associated with Water Permeability Testing
Authors: Ghantous Rita M. , Fronczek Brett , Jablonski Clay B. , Bui Van , Schaef Steve , Reese Steve R. , Weiss W. Jason 
Published: March 2023

Abstract
This study uses neutron radiography to evaluate specimen preparation and test parameters that impact the depth of water penetration in concrete tested under water pressure. First, the impact of the boundary conditions (i.e., the dissipation of pressure that may build up at the lower side of the specimen) on the water penetration throughout the specimen depth was studied. Second, the impact of predrying the specimens (at 65°C) was examined. Third, the depth of water penetration is often measured by splitting the specimen at the end of the permeability test. The use of visual assessment to quantify the depth of water penetration was compared with neutron radiography measurements to determine the accuracy of visual inspection. It was concluded that care should be taken while designing the permeability apparatus to allow pressure dissipation at the lower section of the specimen. The predrying of the specimens at 65°C significantly impacts the permeability and microstructure of the concrete specimens. Finally, water can be seen by the eye when it fills voids with a pore radius greater than 46 nm (i.e., a relative humidity higher than 98.2 ± 0.5 % range, in concrete specimens with a water-to-cement ratio of 0.42 and an air content of 2.5 % content).
Feasibility Study of CO2-Based Vortex Tube Cooling System in Turning of Ti-6Al-4V
Authors: Mahapatro Khirod , Vamsi Krishna P. 
Published: March 2023

Abstract
In titanium alloy machining, a large amount of heat is produced because of the intrinsic characteristics that raise the cutting temperature. In this study, a cooling method known as vortex tube cooling system (VTCS) is used along with carbon dioxide gas coolant to minimize the cutting temperature in Ti-6Al-4V machining. Initially, the optimum value of cold fraction was obtained by considering temperature drop, coefficient of performance, and isentropic efficiency (ηis) at constant coolant pressure. Further, the coolant temperature in the vortex tube varies from room temperature to a steady value that depends on coolant pressure and cold fraction. The trend of cutting temperature and cutting force with change in temperature of coolant and time was analyzed. Cutting force, cutting temperature, and surface roughness were analyzed under different cooling mediums such as dry air, compressed air, cool compressed air cooling (air with vortex tube), and VTCS at constant machining conditions (speed, feed, and depth of cut). From the experimental results, the least cutting temperature and surface roughness were reported under VTCS and the lowest cutting force under dry cutting.
Social Political Roots of Leadership Power In Ulu Malay Lampik Empat Merdike Duwe
Authors: Syawaludin Mohammad 
Published: March 2023

Traditional leadership in modern societies still influences decisions made and social behavior. Emerging influences can be specific values, norms, beliefs, leadership, and knowledge. In the face of social change, even traditional identities are characterized as moral rituals. One is Lampik Empat Merdike Duwe, his four in the leadership tradition of Jagat Besemah. This practice is an ethical standard maintained and passed down in the Basemah community. Phenomenological and qualitative methods were used to interpretively analyze behavioral properties, values, norms, and knowledge data. Using theories of formative and constructive and cultural transformation, the forces and influences of civilization can be divided into three fundamental parts: social, cultural, and behavioral systems. The three methods are interrelated to form a dynamic space based on reference and action. The study found that Lampik empat merdike duwe leadership was socioculturally unable to function in the local leadership power space and only became a moral standard for the Besemah community. The Lampik Empat Merdike Duwe concept of power is more similar to the attribution and attainment status models. Attribution status is the social status given to a person by birth or genetic affiliation. A person cannot choose or achieve this status but is "given" by circumstances.
Diagnostic value of combined use of abbreviated breast MRI and diffusion-weighted MRI in the prediction of breast cancer
Authors: TEZCAN Şehnaz , BEKAR Ülkü , ULU ÖZTÜRK Funda 
Published: March 2023

Purpose: The aim of this study was to compare the diagnostic performances of abbreviated protocol (AP) magnetic resonance imaging (MRI), AP combined with diffusion-weighted imaging (DWI), and full dynamic protocol (FDP) in the differentiation of breast cancers from benign breast diseases.
Materials and Methods: The total study population consisted of 68 patients who underwent breast MRI (1.5 Tesla) between January 2016 and December 2021 for the evaluation of suspicious findings on mammography or ultrasonography. All lesions were evaluated by 2 radiologists using AP, AP+DWI, and FDP. The reader sensitivity, specificity, and accuracy were analyzed using the “Chi-squared” test. The inter-observer agreement (IOA) between the Breast Imaging Reporting and Data System (BI-RADS) category assessments of the two readers was evaluated by using the “Kappa statistics”.
Results: Sixty-eight patients with 72 lesions (31 malignant and 41 benign) were analyzed. The sensitivity/specificity for AP and AP+DWI for reader 1 was 67.7/90.2% and 80.6/87.8%, respectively, and for reader 2 was 67.7/92.6% and 70.9/90.2%, respectively. The sensitivity/specificity for FDP for reader 1 was 83.7/85.3% and for reader 2 was 80.6/90.2%. The IOA in the BI-RADS category assessment was almost perfect in all models between two readers (the kappa value was 0.907, 0.825, and 0.858 in AP, AP+DWI, and FDP, respectively).
Conclusion: FDP showed greater diagnostic efficiency in the characterization of tumor biology as compared to AP and AP +DWI. Combining AP with DWI improved the diagnostic performance of MRI for the determination of malignancy.