bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive factors for treatment response and mortality in chronic pulmonary aspergillosis
Authors: Kosmidis Chris , Smith Holly , Mollett Guy , Harris Chris , Akili Suha , Bazaz Rohit 
Published: August 2023

AbstractObjectivesChronic pulmonary aspergillosis (CPA) is associated with significant mortality, and suboptimal antifungal treatment response. We describe predictive factors for treatment response and survival.MethodsWe retrospectively analysed clinical, serological and radiological parameters at baseline and following antifungal treatment in patients with CPA and correlated with clinical and radiological response and survival.ResultsFifty‐nine patients were included with a mean age of 61 years. Thirty (51%) had a diagnosis of COPD. On clinical assessment at 6 months, 21 (36%) had clinically improved, 20 (34%) were clinically stable and 15 (25%) had deteriorated. Radiological improvement was observed in 30 (53%), stability in 11 (19%) and deterioration in 16 (28%). Only a lower C‐reactive protein (CRP) at baseline was associated with a favourable clinical‐radiological response. On univariate analysis, lower CRP, higher albumin, lower Aspergillus IgG and use of inhaled steroids were associated with lower mortality. An overall favourable response at 6 months was associated with lower mortality.ConclusionInflammatory markers and Aspergillus IgG were predictors of mortality in CPA. This suggests that mortality in CPA is driven mainly by the chronic fungal infection itself rather than the underlying disease, therefore early optimised treatment of CPA may lead to improved outcomes.
Three‐dimensional volumetric evaluation of root resorption in maxillary anteriors following en‐masse retraction with varying force vectors – a randomized control trial
Authors: Prasanna Arvind T. R. , Ramasamy N. , Subramanian A. K. , Selvaraj A. , Siva S. 
Published: August 2023

AbstractBackgroundRoot resorption in orthodontics is associated with direction and magnitude of force application as primary etiological factors. Well‐controlled trials that utilize three‐dimensional segmentation to detect volumetric changes in tooth structure are required to assess the quantitative nature of root resorption.ObjectiveTo assess the severity of root resorption (RR) during retraction of maxillary anteriors with three different force vectors (with and without skeletal anchorage) via cone‐beam computed tomography (CBCT) superimpositions.Trial DesignThree‐arm parallel randomized clinical trial (RCT).Materials and MethodsForty‐two (16 males, 26 females) patients, (17–28 years), in permanent dentition with bimaxillary protrusion were randomly allocated to three groups of 14 patients each using block randomization (1:1:1 ratio) and allocation concealment. En‐masse anterior retraction post first premolar extractions was carried out with modified force vectors in the three groups based on anchorage type [Molar, Mini‐implant and Infrazygomatic crest (IZC) bone screws]. Volumetric root loss and linear dimensional changes were blindly assessed on initial (T0) and final (T1, end of space closure) CBCT scans. Normality distribution of values was done using Shapiro–Wilk's test. ANOVA and Post‐hoc Tukey HSD test were done to compare measurements between groups at significance levels (P < .05).ResultsForty patients were analysed (14, 14, and 12 in three groups). Significant volumetric loss was noted in all groups. Central incisors demonstrated a significant reduction in IZC group (81.5 ± 21.1 mm3) compared to conventional (50.1 ± 26.5 mm3) and mini‐implant groups (76.1 ± 27.6 mm3). Canines demonstrated a significant reduction in mini‐implant group (108.9 ± 33.9 mm3) compared to conventional (68.8 ± 42.5 mm3) and IZC groups (103.1 ± 29.1 mm3). Regarding linear parameters, central incisors and canines revealed significant root length reduction in both skeletal anchorage groups. Lateral incisors showed no significant changes between groups.ConclusionsIntrusive force vectors generated during skeletally anchored retraction can predispose anteriors to an increased risk of resorption. Greater loss of root volume was noted in the centrals and canines when retracted with skeletal anchorage.LimitationsSmall sample size and variations during CBCT acquisition.HarmsLow‐dose CBCT scans were taken at T0 and T1 treatment intervals.
The role of environmental stress in fruit pigmentation
Authors: Espley Richard V. , Jaakola Laura 
Published: August 2023

AbstractFor many fruit crops, the colour of the fruit outwardly defines its eating quality. Fruit pigments provide reproductive advantage for the plant as well as providing protection against unfavourable environmental conditions and pathogens. For consumers these colours are considered attractive and provide many of the dietary benefits derived from fruits. In the majority of species, the main pigments are either carotenoids and/or anthocyanins. They are produced in the fruit as part of the ripening process, orchestrated by phytohormones and an ensuing transcriptional cascade, culminating in pigment biosynthesis. Whilst this is a controlled developmental process, the production of pigments is also attuned to environmental conditions such as light quantity and quality, availability of water and ambient temperature. If these factors intensify to stress levels, fruit tissues respond by increasing (or ceasing) pigment production. In many cases, if the stress is not severe, this can have a positive outcome for fruit quality. Here, we focus on the principal environmental factors (light, temperature and water) that can influence fruit colour.
Properties of given and detected unbounded solutions to a class of chemotaxis models
Authors: Columbu Alessandro , Frassu Silvia , Viglialoro Giuseppe 
Published: August 2023

AbstractThis paper deals with unbounded solutions to a class of chemotaxis systems. In particular, for a rather general attraction–repulsion model, with nonlinear productions, diffusion, sensitivities, and logistic term, we detect Lebesgue spaces where given unbounded solutions also blow up in the corresponding norms of those spaces; subsequently, estimates for the blow‐up time are established. Finally, for a simplified version of the model, some blow‐up criteria are proved.More precisely, we analyze a zero‐flux chemotaxis system essentially described as

The problem is formulated in a bounded and smooth domain Ω of , with , for some , , , and with . A sufficiently regular initial data is also fixed.Under specific relations involving the above parameters, one of these always requiring some largeness conditions on ,

we prove that any given solution to (), blowing up at some finite time becomes also unbounded in ‐norm, for all ;
we give lower bounds T (depending on ) of for the aforementioned solutions in some ‐norm, being ;
whenever , we establish sufficient conditions on the parameters ensuring that for some u0 solutions to () effectively are unbounded at some finite time.

Within the context of blow‐up phenomena connected to problem (), this research partially improves the analysis in Wang et al. (J Math Anal Appl. 2023;518(1):126679) and, moreover, contributes to enrich the level of knowledge on the topic.
Determinants of intangible capital investment in Vietnam: A firm‐level analysis
Authors: Li Qing , Vo Long Hai 
Published: August 2023

AbstractIntangible capital is an important growth driver in the modern knowledge‐based and innovation‐driven economy. While there seems to be sufficient support for the role of intangible capital from developed economies, evidence from fast‐growing developing countries is much more limited. This paper explores the heterogeneous pattern and potential determinants of firm‐level intangible capital investment in Vietnam. We found that firm size, human capital, and information and communication technology increase the likelihood to invest in intangible capital. Additionally, an inverted‐U shaped relation is identified between market competition and intangible capital investment: Moderate levels of market competition induce firms in Vietnam to invest more in innovative activities, but the effect of stronger competition diminishes.
Building the Business Case for Industry 4.0
Authors: O’Heir Jeff 
Published: August 2023

Abstract
Manufacturers are speeding Industry 4.0 adoption as they seek to leverage the improved resiliency, productivity, and agility delivered by digital technologies over the last three years. Lower acquisition costs, ease-of-use, clearer return on investment, a young digital-native workforce eager to explore new solutions, agnostic operating software, and managers less adverse to the risk of bringing on new solutions will continue to drive adoption.
Tribo-Dynamic Performance of Newly Developed Environmentally Friendly Lubricating Greases Containing Nano-CaCO3
Authors: Saxena Ankit , Kumar Deepak , Tandon Naresh 
Published: August 2023

Abstract
The present study explores the performance of novel vegetable oil–based greases containing nano-CaCO3 as an additive. A series of greases with varying nanoparticle concentrations (0–4% w/w) are evaluated on a four-ball tester machine under a standard tribological test (ASTM D2266) and simultaneously in a rolling bearing at various speeds and loads against two commercial greases as the benchmark. The vibrations and shock pulse measurements are recorded to assess the bearing performance. The tribo-dynamic investigation suggests that the eco-friendly nano-greases are at par with the commercial ones; performance varies with the nanoparticle concentration. Under the tribological test, the third-body action of nanoparticles seems to increase friction, while the interfacial deposition (physisorption) of nano-CaCO3 and nano-CaO decreases wear. Under the bearing test, the rolling effect of nanoparticles seems to influence vibrations, while their entrainment in the contact zone governs the carpet values. The nano-grease containing 4% nano-CaCO3 performs best under both assessments, displaying great prospects of a sustainable and potential alternative to existing environmentally unfriendly greases.
Cleavage of 14-3-3ε by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling
Authors: Andrews Daniel D. T. , Vlok Marli , Akbari Bani Dorssa , Hay Brenna N. , Mohamud Yasir , Foster Leonard J. , Luo Honglin , Overall Christopher M. , Jan Eric 
Published: August 2023

ABSTRACT

Viruses have evolved diverse strategies to evade the host innate immune response and promote infection. The retinoic acid-inducible gene I (RIG-I)-like receptors RIG-I and MDA5 are antiviral factors that sense viral RNA and trigger downstream signal via mitochondrial antiviral-signaling protein (MAVS) to activate type I interferon expression. 14-3-3ε is a key component of the RIG-I translocon complex that interacts with MAVS at the mitochondrial membrane; however, the exact role of 14-3-3ε in this pathway is not well understood. In this study, we demonstrate that 14-3-3ε is a direct substrate of both the poliovirus and coxsackievirus B3 (CVB3) 3C proteases (3C
pro
) and that it is cleaved at Q236↓G237, resulting in the generation of N- and C-terminal fragments of 27.0 and 2.1 kDa, respectively. While the exogenous expression of wild-type 14-3-3ε enhances
IFNB
mRNA production during poly(I:C) stimulation, expression of the truncated N-terminal fragment does not. The N-terminal 14-3-3ε fragment does not interact with RIG-I in co-immunoprecipitation assays, nor can it facilitate RIG-I translocation to the mitochondria. Probing the intrinsically disordered C-terminal region identifies key residues responsible for the interaction between 14-3-3ε and RIG-I. Finally, overexpression of the N-terminal fragment promotes CVB3 infection in mammalian cells. The strategic enterovirus 3C
pro
-mediated cleavage of 14-3-3ε antagonizes RIG-I signaling by disrupting critical interactions within the RIG-I translocon complex, thus contributing to evasion of the host antiviral response.

IMPORTANCE
Host antiviral factors work to sense virus infection through various mechanisms, including a complex signaling pathway known as the retinoic acid-inducible gene I (RIG-I)-like receptor pathway. This pathway drives the production of antiviral molecules known as interferons, which are necessary to establish an antiviral state in the cellular environment. Key to this antiviral signaling pathway is the small chaperone protein 14-3-3ε, which facilitates the delivery of a viral sensor protein, RIG-I, to the mitochondria. In this study, we show that the enteroviral 3C protease cleaves 14-3-3ε during infection, rendering it incapable of facilitating this antiviral response. We also find that the resulting N-terminal cleavage fragment dampens RIG-I signaling and promotes virus infection. Our findings reveal a novel viral strategy that restricts the antiviral host response and provides insights into the mechanisms underlying 14-3-3ε function in RIG-I antiviral signaling.
Complete genome sequence of the archetype bile acid 7α-dehydroxylating bacterium,
Clostridium scindens
VPI12708, isolated from human feces, circa 1980
Authors: Olivos Caicedo Kelly Yovani , Fernandez-Materan Francelys V. , Hernandez Alvaro G. , Daniel Steven L. , Alves Joao M. P. , Ridlon Jason M. 
Published: August 2023

ABSTRACT

Clostridium scindens
strain VPI12708 serves as model organism to study bile acid 7α-dehydroxylating pathways. The closed circular genome of
C. scindens
VPI12708 was obtained by PacBio sequencing. The genome is composed of 3,983,052 bp, with 47.59% G + C, and 3,707 coding DNA sequences are predicted.
Draft genome sequence of
Limosilactobacillus reuteri,
isolated from human breast milk
Authors: Tyagi Akanksha , Yeon Su-Jung , Chelliah Ramachandran , Oh Deog-Hwan 
Published: August 2023

ABSTRACT

Limosilactobacillus reuteri
is a lactic acid bacterium with several probiotic properties. Here, we present the draft genome sequence of
L. reuteri
isolated from human breast milk. The average genome size was estimated as 2,087,202 bp, with a guanine-cytosine (GC) content of 51.6%. GC content is the percentage of nitrogenous bases in a DNA or RNA molecule that are either guanine (G) or cytosine (C). De Man, Rogosa and Sharpe, often abbreviated to MRS, is a selective culture medium designed to favor the luxuriant growth of lactobacilli for lab study.
Supplemental Material: Role of volatiles in intrusion emplacement and sulfide deposition in the supergiant Norilsk-Talnakh Ni-Cu-PGE ore deposits
Authors: Barnes Stephen J. , al. et 
Published: August 2023

<p>Geological map (regional and local geology) and stratigraphic column of Paleozoic sedimentary sequence and of the individual ore-hosting intrusions. </p>
Administrative professionals’ quality of life in educational institutions: a systematic review protocol
Authors: Pereira Nicolli Godoi , Silva Regina Márcia Ferreira , Oliveira Isabela Fernanda Rodrigues de , Fernandes Michele da Silva Valadão , Costa Woska Pires da , Vitta Alberto de , Noll Priscilla Rayanne E Silva , Noll Matias 
Published: August 2023

IntroductionIndicators of administrative professionals’ quality of life (QoL) in educational institutions are essential for planning improvements in their daily lives. QoL is a recurring topic in academic research, particularly in the healthcare sector. Therefore, this study aims to evaluate the perceptions of administrative professionals in educational institutions regarding their QoL and the implications of remote and in-person work. Additionally, we aim to compare the QoL before, during and after the COVID-19 pandemic.Methods and analysisFive electronic databases will be searched for this systematic review: CINAHL, LILACS, PubMed, Scopus and Web of Science. Original, peer-reviewed articles published in any language, without time limitations, will be included in this study. Two researchers will screen the articles and extract the data. The included articles will be evaluated for the quality of their evidence using Grading of Recommendations, Assessment, Development and Evaluations. The risk of bias will be assessed using the Critical Appraisal Skills Programme checklist and the Downs and Black scale. A third reviewer will resolve any discrepancies.Ethics and disseminationThe systematic review results will be published in a peer-reviewed journal and presented at a relevant conference. The data will not include individual patient data; therefore, ethical approval is not required.PROSPERO registration numberCRD42022365862.
Effectiveness of a comprehensive tele-empowerment programme on self-care behaviours, uncertainty and readmission of patients with heart failure: protocol for a randomised controlled trial
Authors: Khanipour-Kencha Ali , Ghiyasvandian Shahrzad , Mohammadi Somaye , Khabazkhoob Mehdi , Mirshahi Arvin , Wells Rachel , Zakerimoghadam Masoumeh 
Published: August 2023

IntroductionHeart failure (HF) as a long-term clinical syndrome is associated with inadequate self-care behaviours, a feeling of uncertainty and frequent hospitalisation. In recent years, empowerment has evolved for improving chronic disease management. Nevertheless, there is a lack of studies investigating remote care interventions such as a tele-empowerment programme in patients with HF. Therefore, this protocol proposes a randomised controlled trial which aims to evaluate the effectiveness of a comprehensive tele-empowerment programme on self-care behaviours, uncertainty and readmission in patients with HF.Methods and analysisThe study is a double-arm and parallel-group randomised controlled trial in which a 10-week intervention, including 6 weeks of a comprehensive tele-empowerment programme and 4 weeks of follow-up, will be compared with usual care. A total of 96 eligible patients with HF will be recruited and randomly assigned to the intervention or control group. The patients in the intervention group will join virtual groups and receive the five-step tele-empowerment programme through the internet. The primary outcomes include self-care behaviours and uncertainty which will be measured with valid instruments at baseline and 10th week. The secondary outcome is the number of patients’ hospital readmissions and will be assessed at the end of the study. Descriptive statistics will be used to describe variables. According to the types of variables, appropriate statistical tests including two-sample t-tests, Χ2, analysis of covariance or linear regression will be performed. In addition, standardised intervention effect sizes will be calculated for each outcome.Ethics and disseminationThe trial has been approved by the Research Ethics Committee of School of Nursing and Midwifery & Rehabilitation at Tehran University of Medical Sciences. In this study, written consent will be obtained from all participants. The results will be presented to representative groups and published in peer-reviewed journals.Trial registration numberIranian Registry of Clinical Trials (IRCT20100725004443N30).
Balanced resuscitation and earlier mortality end points: bayesian post hoc analysis of the PROPPR trial
Authors: Lammers Daniel , Rokayak Omar , Uhlich Rindi , Sensing Thomas , Baird Emily , Richman Joshua , Holcomb John B , Jansen Jan 
Published: August 2023

IntroductionThe Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial failed to demonstrate a mortality difference for hemorrhaging patients receiving a balanced (1:1:1) vs a 1:1:2 resuscitation at 24 hours and 30 days. Recent guidelines recommend earlier mortality end points for hemorrhage-control trials, and the use of contemporary statistical methods. The aim of this post hoc analysis of the PROPPR trial was to evaluate the impact of a balanced resuscitation strategy at early resuscitation time points using a Bayesian analytical framework.MethodsBayesian hierarchical models were created to assess mortality differences at the 1, 3, 6, 12, 18, and 24 hours time points between study cohorts. Posterior probabilities and Bayes factors were calculated for each time point.ResultsA 1:1:1 resuscitation displayed a 96%, 99%, 94%, 92%, 96%, and 94% probability for mortality benefit at 1, 3, 6, 12, 18, and 24 hours, respectively, when compared with a 1:1:2 approach. Associated Bayes factors for each respective time period were 21.2, 142, 14.9, 11.4, 26.4, and 15.5, indicating ‘strong’ to ‘decisive’ supporting evidence in favor of balanced transfusions.ConclusionThis analysis provides evidence in support that a 1:1:1 resuscitation has a high probability of mortality benefit when compared with a 1:1:2 strategy, especially at the newly defined more proximate time points during the resuscitative period. Researchers should consider using Bayesian approaches, along with more proximate end points when assessing hemorrhage-related mortality, for the analysis of future clinical trials.Level of evidenceLevel III/Therapeutic.
Cardiac autonomic modulation in individuals with controlled and uncomplicated hypertension during exercise-heat stress
Authors: Carrillo Andres E. , Akerman Ashley P. , Notley Sean R. , Herry Christophe L. , Seely Andrew J.E. , Ruzicka Marcel , Boulay Pierre , Kenny Glen P. 
Published: August 2023

Impaired cardiac autonomic modulation is implicated in the development of hypertension. Exercise improves sympathovagal balance and is often prescribed for hypertension management. Environmental conditions, however, are not considered during the development of these exercise recommendations. We examined cardiac autonomic modulation, assessed using heart rate variability (HRV), in individuals (49–77 years) with ( n = 20) and without ( n = 28) controlled, uncomplicated hypertension performing three 30 min bouts of exercise (light, moderate, and vigorous) in dry heat (40.2 ± 0.3 °C, 17% ± 7% relative humidity), each separated by 15 min breaks. Regardless of intensity, short bouts of exercise-heat stress did not significantly disrupt HRV in physically active individuals with hypertension relative to normotensives. Take-home message During short bouts of light-to-vigorous exercise in the heat, controlled and uncomplicated hypertension did not significantly modulate HRV in physically active individuals. These findings can be used to refine guidance on use of exercise for hypertension management in the heat.
External Genitalia Myiasis in a 40-Year-Old Woman
Authors: Mansouri Ghazal , Allahqoli Leila , Salehiniya Hamid , Alkatout Ibrahim 
Published: August 2023

Human myiasis is an infestation produced by fly larvae invading the tissues. We present a case of a 40-year-old virgin woman with vulvar myiasis. She reported at the gynecology clinic with a bloody discharge, severe pain, and swelling of the genital area for six days. Her menstrual history revealed the use of folded clothes. She had no specific gynecological disease. At the examination of the external genitalia, a tender mass measuring

6

cm
×
4

cm

and an ulcer measuring

1

cm
×
1

cm

on the surface of the labia majora were found. The patient was hospitalized. Serology, blood, and urine tests were requested; all laboratory tests were normal. The patient was transferred to the operating room (OR) with the diagnosis of necrotizing fasciitis. In the OR, we performed a longitudinal incision on the mass and removed nearly 30 visible maggots. After washing with normal saline, the patient was transferred to the ward without wound suturing. Debridement of the necrotic vulvar mass along with daily washing was performed for 7 days. The wound was sutured on the seventh day at the OR. Antibiotic therapy was continued for 4 days, and the patient was discharged with normal laboratory tests on the eleventh day after admission. We believe that poor sanitary hygiene was the cause of vulvar myiasis in our patient. We conclude that appropriate measures must be taken to reduce the risk of human myiasis, especially in tropical rural regions.