bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment and application of unbiasedin vitrodrug screening assays for the identification of compounds againstEchinococcus granulosus s.s
Authors: Kaethner Marc , Preza Matías , Kaempfer Tobias , Zumstein Pascal , Tamponi Claudia , Varcasia Antonio , Hemphill Andrew , Brehm Klaus , Lundström-Stadelmann Britta 
Published: May 2023

AbstractEchinococcus multilocularisandE. granulosus s.l.are the causative agents of alveolar and cystic echinococcosis, respectively. Drug treatment options for these severe and neglected diseases are limited to benzimidazoles, which are not always efficacious, and adverse side effects are reported. Thus, novel and improved treatments are needed.In this study, the previously established platform forE. multilocularis in vitrodrug assessment was adapted toE. granulosus s.s.. In a first step,in vitroculture protocols forE. granulosus s.s.were established. This resulted in the generation of large amounts ofE. granulosus s.s.metacestode vesicles as well as germinal layer (GL) cells.In vitroculture of these cells formed metacestode vesicles displaying structural characteristics of metacestode vesicles generatedin vivo. Next, drug susceptibilities ofE. multilocularisandE. granulosus s.s.protoscoleces, metacestode vesicles and GL cells were comparatively assessed employing established assays including (i) metacestode vesicle damage marker release assay, (ii) metacestode vesicle viability assay, (iii) GL cell viability assay, and (iv) protoscolex motility assay. The standard drugs albendazole, buparvaquone, mefloquine, MMV665807, monepantel, niclosamide and nitazoxanide were included. MMV665807, niclosamide and nitazoxanide were active against the parasite in all four assays against both species. MMV665807 and monepantel were significantly more active againstE. multilocularismetacestode vesicles, while albendazole and nitazoxanide were significantly more active againstE. multilocularisGL cells. Albendazole displayed activity againstE. multilocularisGL cells, but no effects were seen in albendazole-treatedE. granulosus s.s.GL cells within five days. Treatment of protoscoleces with albendazole and monepantel had no impact on motility. Similar results were observed for both species with praziquantel and its enantiomers against protoscoleces. In conclusion,in vitroculture techniques and drug screening methods previously established forE. multiloculariswere successfully implemented forE. granulosus s.s.,allowing comparisons of drug efficacy between the two species.
Inferring control objectives in a virtual balancing task in humans and monkeys
Authors: Sadeghi Mohsen , Razavian Reza Sharif , Bazzi Salah , Chowdhury Raeed , Batista Aaron , Loughlin Patrick , Sternad Dagmar 
Published: May 2023

AbstractNatural behaviors have redundancy, which implies that humans and animals can achieve their goals with different control objectives. Given only observations of behavior, is it possible to infer the control strategy that the subject is employing? This challenge is particularly acute in animal behavior because we cannot ask or instruct the subject to use a particular control strategy. This study presents a three-pronged approach to infer an animal’s control strategy from behavior. First, both humans and monkeys performed a virtual balancing task for which different control objectives could be utilized. Under matched experimental conditions, corresponding behaviors were observed in humans and monkeys. Second, a generative model was developed that represented two main control strategies to achieve the task goal. Model simulations were used to identify aspects of behavior that could distinguish which control objective was being used. Third, these behavioral signatures allowed us to infer the control objective used by human subjects who had been instructed to use one control objective or the other. Based on this validation, we could then infer strategies from animal subjects. Being able to positively identify a subject’s control objective from behavior can provide a powerful tool to neurophysiologists as they seek the neural mechanisms of sensorimotor coordination.Impact statementA computational approach identifies control objectives in humans and monkeys to serve as basis for analysis of neural correlates of skillful manipulation.
Age-related increases in IGFBP2 increase melanoma cell invasion and lipid synthesis
Authors: Alicea Gretchen M. , Portuallo Marie E. , Patel Payal , Fane Mitchell E. , Carey Alexis E. , Speicher David , Tang Hsin-Yao , Kossenkov Andrew V. , Rebecca Vito W. , Wirtz Denis G. , Weeraratna Ashani T. 
Published: May 2023

AbstractAged melanoma patients (>65 years old) have more aggressive disease relative to young patients (<55 years old) for reasons that are not completely understood. Analysis of the young and aged secretome from human dermal fibroblasts identified >5-fold levels of insulin-like growth factor binding protein 2 (IGFBP2) in the aged fibroblast secretome. IGFBP2 functionally triggers upregulation of the PI3K-dependent fatty acid biosynthesis program in melanoma cells through increases in FASN. Melanoma cells co-cultured with aged dermal fibroblasts have higher levels of lipids relative to young dermal fibroblasts, which can be lowered by silencing IGFBP2 expression in fibroblasts, prior to treating with conditioned media. Conversely, ectopically treating melanoma cells with recombinant IGFBP2 in the presence of conditioned media from young fibroblasts, promoted lipid synthesis and accumulation in the melanoma cells. Neutralizing IGFBP2in vitroreduces migration and invasion in melanoma cells, and invivostudies demonstrate that neutralizing IGFBP2 in syngeneic aged mice, ablates tumor growth as well as metastasis. Conversely, ectopic treatment of young mice with IGFBP2 in young mice increases tumor growth and metastasis. Our data reveal that aged dermal fibroblasts increase melanoma cell aggressiveness through increased secretion of IGFBP2, stressing the importance of considering age when designing studies and treatment.SignificanceThe aged microenvironment drives metastasis in melanoma cells. This study reports that IGFBP2 secretion by aged fibroblasts induces FASN in melanoma cells and drives metastasis. Neutralizing IGFBP2 decreases melanoma tumor growth and metastasis.
Autonomous development and regeneration of isolated rice egg cells in a fertilization-independent manner
Authors: Rattanawong Kasidit , Totsuka Kaori , Koshimizu Shizuka , Yano Kentaro , Okamoto Takashi 
Published: May 2023

AbstractParthenogenesis is suppressed in rice egg cells to avoid precocious development before fertilization. We found that cold treatment released cell cycle arrest in egg cells and triggered mitosis. Egg cells isolated fromjaponica(Nipponbare; NB) andaus(Kasalath; KS) subspecies divided and regenerated into mature plants after cold treatment. The egg-derived plants showed variety of ploidy levels, including haploid (n), diploid (2n), and tetraploid (4n). Nuclear DNA quantification showed that genome duplication occurred during early parthenogenetic development. Owing to the presence of single nucleotide polymorphisms (SNPs) between NB and KS, inter-subspecific hybrid plants (NB-KS hybrids) were created via electrofusion. Egg cells from the NB-KS hybrid developed parthenogenetically into polyploid plants. 2n and 4n plants originating from the same NB-KS egg cell displayed the same homozygous SNP patterns throughout the genome, indicating that these plants were doubled and quadrupled haploids. Transcriptome analyses of cold-treated egg cells demonstrated that parthenogenesis-related candidate genes, includingOsBBML1, were upregulated.
A systematic review on homo Islamicus: classification and critique
Authors: Sholihin Muhammad , Sugiyanto Catur , Susamto Akhmad Akbar 
Published: May 2023

PurposeThis paper aims to systematically review the concept of homo Islamicus discussed in the existing literature. The second objective is to offer a set of criticisms of the descriptions of homo Islamicus.Design/methodology/approachIn this paper prespecified eligibility criteria are applied to select articles that are indexed in Scopus and ProQuest, or published by two major publishers, ScienceDirect and Emerald, or appear on ResearchGate. A set of books related to homo Islamicus was also used as secondary sources to support the selected articles. As a result, this paper systematically reviews 53 articles and four books to synthesize the homo Islamicus.FindingsThere are four notions of homo Islamicus: Firstly, homo Islamicus as the kind of economic agent that is required to achieve Islamic economic objectives. Secondly, homo Islamicus as a defining factor that makes the difference between Islamic and conventional economics. Thirdly, homo Islamicus as an economic agent whose characteristics are something Islamic economics aims to realize. Lastly, homo Islamicus as an economic agent representing the fundamental assumption in Islamic economics.Practical implicationsMapping homo Islamicus can be helpful for future researchers to conduct analyses related to homo Islamicus, especially in the context of empirical studies of the existence of homo Islamicus in economic reality. This literature review can help other researchers to understand the development of literature related to homo Islamicus.Originality/valueThis paper seems to be the first to systematically identify, select and synthesize the description of homo Islamicus in the literature.
Don’t we have a right to get angry? Integrating emotions into international mediation studies
Authors: Nathan Laurie , Devonshire Joel M. 
Published: May 2023

Purpose
This paper aims to critique the rationalist theoretical framework of international mediation, which ignores emotions in analyzing the decision by conflict parties to pursue a negotiated settlement or continue fighting, and to present an alternative framework that integrates emotions.

Design/methodology/approach
The paper draws on psychology research on emotions and conflict to develop an emotionally informed framework for analyzing conflict parties’ decision-making regarding a settlement. It demonstrates the framework’s validity and value through a case study of the 2000 Camp David mediation to resolve the Israeli–Palestinian conflict.

Findings
A rationalist approach to mediation does not have adequate explanatory and predictive power theoretically. In practice, it can reduce the prospect of success.

Research limitations/implications
The paper highlights the necessity for mediation researchers to study the effects of emotion, draw on psychology studies on conflict and explore the emotional implications of different mediation strategies and tactics.

Practical implications
The framework highlights the challenge of designing and conducting mediation in a way that cultivates emotions favorable to a settlement and lessens emotions unfavorable to a settlement.

Originality/value
This is the first study, to the best of the authors’ knowledge, to critique the rationalist framework of international mediation studies and develop an alternative framework that integrates emotions.
Revising a performance measurement and control system of an organization
Authors: Globerson Shlomo 
Published: May 2023

Purpose
This paper aims to explore the changes that an organizational performance and control system should perform to adapt to the current dynamic environment.

Design/methodology/approach
This paper first presents the features of a typical organizational control system. It identifies current technological developments that affect the control process and evaluates the changes that should be introduced in order for the organization to function effectively.

Findings
Although the components of organizational performance and control systems remain the same, most of them have changed their features, such as strategy should be visited more frequently, processes are digitized and therefore customers are more involved in the process, and actual performance can and should be monitored automatically.

Originality/value
This paper presents a comprehensive model of a control system that can be implemented by every organization, as well as points out control features that should be continuously reviewed and updated.
Doing good right: building resilience through donations during the pandemic
Authors: Han Zhaojun , Jiang Shenyang , Zheng Zhanzhi , Jin Yong 
Published: May 2023

PurposeWhile researchers recognize the significance of philanthropic donations in disaster relief and recovery, the benefits that firms derive from such donations remain unclear, particularly when firms are adversely impacted by the disaster. To address this gap, this study seeks to elucidate the impact of various donation strategies on firm resilience in the context of the COVID-19 pandemic.Design/methodology/approachBased on the hand-collected data on donations, the authors employ ordinary least squares regressions to investigate the effectiveness of various donation strategies – including type, timing and location – in enhancing firm resilience in terms of the severity of stock price losses during the pandemic. To address potential endogeneity concerns, the authors use a two-stage least squares regression with instrumental variables.FindingsThis study finds robust evidence that certain donation strategies are more effective at mitigating stock price losses during the pandemic. Specifically, the authors find that in-kind donations (compared to monetary ones), earlier donations (compared to later ones) and donations targeting severely impacted areas (Hubei province vs. other places) are more effective methods to reduce the severity of stock price losses.Originality/valueThis study points out an alternative mechanism through which donations influence firm resilience during a crisis context and provides important managerial implications for firms to better engage in disaster donations.
More than two decades of research on IoT in agriculture: a systematic literature review
Authors: Bulut Cevdet , Wu Philip Fei 
Published: May 2023

PurposeAgriculture is one sector where the Internet of things (IoT) is expected to make a major impact. Yet, its adoption in the sector falls behind expectations. The purpose of this paper is to present the state-of-the-art of IoT in agriculture and investigate its slow adoption in the sector.Design/methodology/approachThe authors have undertaken a systematic review and a synthesis of 1355 relevant publications over the last decade.FindingsThis literature review reveals that the “big three” barriers for the overall sector are cost, skills and standardization. The lack of connectivity and data governance are two key reasons why most of the proposed IoT solutions are standalone systems of limited scope, while the majority of commercial IoT efforts focus on practices in the protected indoor environment. Lastly, the analysis of past research along the five layers of the IoT system architecture reveals limited attention to barriers and solutions at the business layer, which represents a research opportunity for information systems scholars.Research limitations/implicationsIt is possible that some of relevant publications were missed in the literature search, although the search queries were kept as broad as possible to avoid the exclusion of any relevant work. Any publication written in any other language other than English was excluded from the review. Given the geographical distribution of the reviewed English publications (see section 4.1), it is highly likely that important works written by Chinese and European scholars in their native language were overlooked.Practical implicationsThis study provides practical insights into the technical and organisational challenges on the ground. It is the hope that this literature review lays the groundwork for IS researchers who are well positioned to investigate technology adoption challenges in the relatively understudied agriculture sector.Originality/valueTo the best of the authors’ knowledge, this is the first comprehensive review of adoption barriers and solutions across all five layers of the IoT system architecture.
Examining the effects of disinformation and trust on social media users' COVID-19 vaccine decision-making
Authors: Westney Zulma Valedon , Hur Inkyoung , Wang Ling , Sun Junping 
Published: May 2023

PurposeDisinformation on social media is a serious issue. This study examines the effects of disinformation on COVID-19 vaccination decision-making to understand how social media users make healthcare decisions when disinformation is presented in their social media feeds. It examines trust in post owners as a moderator on the relationship between information types (i.e. disinformation and factual information) and vaccination decision-making.Design/methodology/approachThis study conducts a scenario-based web survey experiment to collect extensive survey data from social media users.FindingsThis study reveals that information types differently affect social media users' COVID-19 vaccination decision-making and finds a moderating effect of trust in post owners on the relationship between information types and vaccination decision-making. For those who have a high degree of trust in post owners, the effect of information types on vaccination decision-making becomes large. In contrast, information types do not affect the decision-making of those who have a very low degree of trust in post owners. Besides, identification and compliance are found to affect trust in post owners.Originality/valueThis study contributes to the literature on online disinformation and individual healthcare decision-making by demonstrating the effect of disinformation on vaccination decision-making and providing empirical evidence on how trust in post owners impacts the effects of information types on vaccination decision-making. This study focuses on trust in post owners, unlike prior studies that focus on trust in information or social media platforms.
Understanding consumer adoption of mobile payment in Pakistan
Authors: Khan Salman , Khan Safeer Ullah , Khan Ikram Ullah , Khan Sher Zaman , Khan Rafi Ullah 
Published: May 2023

Purpose
This study aims to explore the consumers’ choices of mobile payments (m-payments) using a comprehensive unified model. The financial technology for digital m-payment has been increasingly introduced in the market, yet their acceptance has remained low.

Design/methodology/approach
This study uses the unified theory of acceptance and use of technology (UTAUT) with additional constructs of social influence, trust, anxiety, personal innovativeness and grievance redressal (GR). Structural equation modeling is used to evaluate the predictive model of attitudes toward m-payment. Individuals’ responses to questions regarding their attitude and intention to accept m-payment were gathered and examined through the lens of extended UTAUT model.

Findings
While the model supports TAM classical role, empirical examination of the model revealed that users’ attitudes and intentions are influenced by trust, personal innovativeness and social influence. Moreover, intention to use and GR are significant positive predictors of m-payment usage behavior.

Originality/value
M-payment provides customers with new digital payment platforms while providing businesses and marketing agents with more alternatives for online marketing. However, there is not much reported about m-payment adoption in Pakistan. This research introduces and evaluates new constructs that were not included in the original model. In Pakistan, to the best of the authors’ knowledge, this is a first of its kind of research which is purely based on the customers’ perspective of m-payment adoption.
Strategic HRM practices, learning orientation and learning competence: study from retail industry
Authors: P. Arunprasad , Dey Chitra , Santhanam Nivethitha , Bin Ahmad Kamarul Zaman 
Published: May 2023

Purpose
This study aims to examine the effect of strategic human resource management (SHRM) practices on two learning outcomes, learning orientation and learning competence, which past research has seldom examined in the UAE context. SHRM practices consisted of four factors, namely, talent acquisition, learning and development, performance appraisal and developmental pay.

Design/methodology/approach
Primary data was collected from 285 employees from retail outlets operating in Dubai. Partial least squares regression analysis using the tool, SmartPLS, was used to empirically validate the measurement model and test the structural model.

Findings
Findings reveal that SHRM practices talent acquisition, learning and development and developmental pay have a positive association with learning orientation, and learning and development and performance appraisal have a positive association with learning competence of employees. The path coefficient and total effects signify that learning orientation acts as a conduit to pass on the effect of the SHRM practices to learning competence.

Research limitations/implications
The sample considered for the study was from the retail industry. Furthermore, to generalize the findings of this research, cross-national studies should be conducted across various sectors and organizations.

Originality/value
To the best of the authors’ knowledge, this research study is the first of its kind in retail firms in Dubai (UAE) to empirically test the association of SHRM practices with learning outcomes. Retail outlets can implement SHRM practices to improve learning orientation and learning competence in a highly dynamic operating environment such as retail industry.
Maintenance of biodiversity in multitrophic metacommunities: Dispersal mode matters
Authors: Ye Xiaozhou , Wang Shaopeng 
Published: May 2023

Abstract

Although metacommunity models generally formulate dispersal as a random, passive process, mounting evidence suggests that dispersal can be an active process depending on species fitness over the landscape, particularly in multitrophic communities. How different dispersal modes (i.e. from random to increasingly fitness‐dependent dispersal) modulate the effect of dispersal on biodiversity remains unclear. Here, we used a metacommunity model of food webs to investigate the effects of dispersal and habitat heterogeneity on biodiversity and how these effects may be dependent on dispersal mode.

Our results showed that compared to isolated systems, random dispersal increased local food web diversity ( diversity) but decreased across‐community dissimilarity ( diversity) and regional food web diversity ( diversity), consistent with findings from competitive metacommunity models. However, fitness‐dependency could alter the effects of dispersal on biodiversity. Both and diversity increased with the strength of fitness‐dependency of dispersal, while diversity peaked at intermediate fitness‐dependency. Notably, strong fitness‐dependent dispersal maintained levels of and diversity similar to those observed in isolated systems. Thus, random dispersal and isolation (i.e. no dispersal) can be considered as two extremes along the continuum of fitness‐dependent dispersal, in terms of their effects on biodiversity.

Moreover, both biodiversity‐habitat heterogeneity and biodiversity‐habitat connectivity relationships depended on the dispersal mode. Strikingly, under random dispersal, diversity decreased with habitat heterogeneity and connectivity, but under strong fitness‐dependent dispersal, it increased with habitat heterogeneity and remained unchanged as habitat connectivity increased.

Our study highlights the context dependence of dispersal effects on biodiversity in heterogeneous landscapes. Our findings have useful implications for biodiversity conservation and landscape management, where management strategies should account for different modes of dispersal across taxa, thus different responses of biodiversity to habitat heterogeneity and connectivity.