bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of Poly(Adenosine Diphosphate-Ribose) Polymerase Protein in Breast Cancer
Authors: Akanksha  , Mishra Shashi Prakash , Kar Amrita Ghosh , Karthik J. S. , Srivastava Aviral , Khanna Rahul , Meena Ram Niwas 
Published: January 2023

Background:
The use of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors for breast cancer (BC) therapy is the subject of debate, and there is an urgent need to understand much the expression and prognostic role of the PARP1 protein. In this study, we have compared the expression of PARP between BC and benign breast disease (BBD) patients and also analyzed the association of PARP expression with clinicopathological parameters in BC.

Methods:
The study consists of 30 patients with newly diagnosed operable BC who were planned for surgery without neoadjuvant chemotherapy and 15 patients of BBD as a control between 2019 and 2021. Immunohistochemical analyses were performed prospectively on tissue samples. Anti-human PARP1 rabbit polyclonal antibody gives strong nuclear positivity. Internal control was the adipose tissue and the BBD acted as the external control. PARP1 expression was evaluated using the multiplicative quickscore method.

Results:
The mean age for BC patients was 51.30 ± 10.694 years (range: 25–75 years) while BBD was below 30 years. Overexpression of PARP was present in 25 (83.3%) and weak expression in 5 (16.7%) of BC patients compared to BBD, only 2 (13.3%) patients demonstrated an overexpression of PARP, and 13 (86.6%) patients showed weak expression which showed significant association (P < 0.001). In BC, nuclear PARP (nPARP) overexpression was seen in 22 (73.3%) patients and weak expression of nPARP in 8 (26.7%), whereas 5 (16.7%) patients showed cytoplasmic overexpression. On comparing expression of PARP with clinicopathological parameters, PARP overexpression was significantly associated with older population (age >50 years) (P = 0.002), postmenopausal women (P = 0.029), higher TNM stage (Stage II and III) (P = 0.014), higher histological grade (grade 2) (P = 0.043), and presence of lymphovascular invasion (P = 0.015). Enhanced PARP1 expression is closely correlated with positive estrogen receptor status (P = 0.001) and PR status (P = 0.001). Overall PARP and nPARP overexpression was significantly associated with ER- (P = 0.006 and P = 0.008) and PR-positive (P = 0.006 and P = 0.008) patients. The PARP and nPARP overexpression was significantly associated with nontriple-negative BC patients (P = 0.001 and P = 0.001).

Conclusion:
We have not come across any study in the literature to compare PARP expression in BC and BBD patients. On the basis of our observations, we concluded that PARP overexpression is a poor prognostic marker in BC.
Quality of Life in Patients Undergoing Endovenous Laser Ablation and Saphenofemoral Ligation and Stripping
Authors: Madhu Deepesh D. , Saji M. T. , Manilal P. K. 
Published: January 2023

Introduction:
Surgery for varicose veins was the treatment of choice before the advent of minimally invasive procedures.

Aim:
This study was done to compare the utility of endovenous laser ablation (EVLA) as an effective alternative to surgery to treat varicose veins.

Materials and Methods:
The study was conducted in a tertiary care hospital between October 2019 and March 2021. One hundred and six patients with varicose veins of the long saphenous system were included in the study, 53 in the laser surgery group and 53 in the open surgery group. European Quality of life 5 dimensions questionnaire, the WHO VAS score and clinical aetiological, anatomical and pathological classification for varicose veins scores of the affected limb of the patients were recorded preoperatively and postoperatively at day 90. Data were statistically analysed using SPSS.

Results:
Patients treated by EVLA enjoyed a better quality of life than the ligation and stripping group. They experience significant reduction in the post-operative pain, the absence of wound infection and a significant reduction in the clinical severity scores.

Conclusion:
EVLA is a safer and effective means for treating varicose veins.
Intraoperative Parathyroid Hormone Assay to Guide Completion of Parathyroid Surgery
Authors: Shaju S. , Varghese Melvin , Saran N. , Safwam A Mohamad 
Published: January 2023

Introduction:
Primary hyperparathyroidism (pHPT) is characterised by an autonomous production of parathyroid hormone (PTH), which causes hypercalcemia. It is classified into adenoma, glandular hyperplasia and carcinoma. The standard treatment for the pHPT has been bilateral neck exploration (BNE) and the visualisation of all parathyroid glands. However, the increasing sensitivity of pre-operative localisation methods such as 99Tc-sestamibi scanning and ultrasound in combination with intra-operative PTH monitoring (ioPTH) assay can be utilised to decrease the need of BNE and subsequent complications. The aim of the study was to determine the effectiveness of ioPTH during parathyroidectomy and to assess the effectiveness of ioPTH in surgery for pHPT.

Materials and Methods:
Thirty-one patients admitted to the general surgery department in our tertiary care centre with hyper-parathyroidism and underwent parathyroidectomy, whose ioPTH evaluation was done were considered for the study. Their pre-operative and post-excision (10 min after excision of suspicious gland) values of PTH were as noted. Reduction in ioPTH value, based on MIAMI criteria was considered as the eradication of hyper-functioning tissues and its effectiveness in confirming the success of pHPT-surgery in terms of post-operative serum calcium level, thereby evaluating MIAMI criteria.

Results:
Twenty-nine (90.6%) patients showed a reduction of more than 50% in PTH following excision of suspicious glands from pre-operative PTH which is statistically significant, whereas only 21 (65.6%) patient shows normal PTH value following excision of suspicious gland. However, all 31 patients showed decline in PTH value as compared to pre-excision value.

Conclusion:
When the abnormal parathyroid gland is excised, there will be the reduction of PTH more than 50% from their pre-excisional value. Hence, by utilising ioPTH assay to confirm the excision of pathological gland, we can reduce BNE.
Incidence and Role of Large Vessel Disease in Diabetic Foot
Authors: Sasidharan Akash , Khan Shafy S. L. Ali , Khan Firoz M. H. , Namita U. 
Published: January 2023

Introduction:
Diabetic patients are at risk for considerable morbidity as a result of chronic foot ulceration and infection, including limb loss. Diabetic foot infections are usually a consequence of skin ulceration from ischaemia or trauma to a neuropathic foot. The accurate diagnosis of the underlying cause is very important in planning the treatment. The aim of the study was to study the incidence and role of large vessel disease in patients with diabetic foot.

Materials and Methods:
Seventy-five patients admitted with features of diabetic foot and its complications were included in the study after excluding patients of comorbid medical illness. The presence of macrovasculopathy was assessed by examination for peripheral pulses, followed by assessment using arterial Doppler amongst patients with macrovasculopathy, those with gangrene or non-healing ulcers and those who underwent amputations or disarticulations were analysed.

Results:
Clinically, dorsalis pedis artery pulses were absent in 81.3% and posterior tibial artery pulses were absent in 54.7%. In arterial Doppler, involvement is 66.7% for dorsalis pedis and 68% for posterior tibial. Fifty-six percentage of patients ended up having poor outcomes in the form of amputations or disarticulations. There is a significant incidence of large vessel disease, especially in elderly patients who were diabetic for more than 10 years. Large vessel disease seems to have a significant role in the final outcome of diabetic foot complications.

Conclusions:
Vasculopathy is a strong risk factor in the development of diabetic foot lesions. An arterial Doppler will help detect involvement early in cases presenting with diabetic foot complications. The presence of diabetic microvascular disease imparts an even greater importance on the early detection and treatment of significant macrovascular disease.
Effectiveness of Acute Physiology and Chronic Health Evaluation-Ii Scoring in Predicting Outcomes of Perforation Peritonitis
Authors: Sathyapal Goutham P. , Oommen Alex 
Published: January 2023

Introduction:
Several scoring systems have been developed for predicting the severity and outcomes of peritonitis, such as the Acute Physiology and Chronic Health Evaluation (APACHE-II) score, Ranson's score and Mannheim's peritonitis index. The aim of the study was to evaluate the performance of the APACHE-II scoring system in predicting mortality and morbidity in patients with perforation peritonitis.

Methods:
Diagnostic test evaluation was done from June 2020 to December 2021, including 168 patients with hollow viscous perforation, excluding appendicular abscess perforation, who attended the casualty and underwent surgery. Data were collected by meticulous history, clinical examination, radiological, histopathological and serological investigation, operative findings and follow-up till discharge or death. The outcome of the study is based on an analysis of mortality and morbidity due to perforation peritonitis and its correlation with the scores obtained based on APACHE-2 scoring system.

Results:
The commonest age group of perforation peritonitis was 41–50 years of age (21.4%), with male preponderance. The most common site of perforation was gastric in all age groups, and the most common aetiology was peptic ulcer, followed by malignancy. The mortality rate was 10.7%, and the rates are higher for females, older age groups, and malignancies. There was a statistically significant association for APACHE-II score in predicting the mortality, complications and morbidity associated with perforation peritonitis. The average APACHE-II score in this study was 6.17 and the average score among survivors was 4.33 and non-survivors 21.44. Morbidity and mortality increased as the score increased; a score above 15 had a sensitivity of 99% and specificity of 94.4% in predicting mortality, the complication rates were more in scores above 10. The low-risk categories (0–5 and 6–10) had a favourable outcome in terms of morbidity and mortality.

Conclusions:
The mean age was 46.6 years with male preponderance. The most common aetiology was peptic ulcer perforation, followed by perforation due to malignancies and site of perforation being the stomach, followed by colon. There was a statistically significant association for APACHE-II score in predicting the mortality, complications and morbidity associated with perforation peritonitis and score above 15 has a sensitivity of 99% and a specificity of 94.4% in predicting mortality associated with secondary peritonitis.
The Perioperative Outcome in Geriatric Patients Undergoing Major Gastrointestinal Surgery
Authors: Anantha Krishna V. R. , Shabeer Ali T. U. , Safwan A Mohamad 
Published: January 2023

Background:
The surgical impact on the 30-day mortality and morbidity in geriatric patients is a scarcely studied topic. The aims of this study were to identify the 30-day morbidity and mortality in geriatric patients undergoing major gastrointestinal surgery and to identify the risk factors associated with the same.

Materials and Methods:
A cross-sectional study was conducted on 93 patients at a tertiary care centre. Thirty-day morbidity was broadly grouped into wound, renal, cardiac, respiratory, psychiatric, neurologic complications and others. The complications were also graded into five based on the Clavien–Dindo classification. Data were analysed using appropriate statistical methods.

Results:
The 30-day mortality in our study was 3.2%. The 30-day overall morbidity was 58.06%. Grade 2 and above Clavien–Dindo complications were encountered in 25/93 patients – 26.9%. There was an increased risk of Grade 2 and above Clavien–Dindo surgical complications in patients who had prior history of falls, who had timed up and go test more than 14 s, who had significant weight loss, who were operated for malignant causes and those who underwent open surgeries. Majority of complications occurred in the 65–69-year age group. Patients operated for non-malignant causes had no post-operative complications in our study.

Conclusion:
Elective surgery is generally well tolerated by the elderly. Age should not be used as the only criterion when deciding suitability for surgery in this age group. The results of elective surgery in the elderly are in fact reproducibly good, especially in non-malignant causes.
Boshlang‘ich sinf o‘quvchilarida ilmiy dunyoqarashni fanlararo shakllantirish metodikasini takomillashtirishning pedagogik shart-sharoitlari
Authors: Toshpulatova Niyoxon 
Published: January 2023

Ushbu maqolada bugungi davr ta’limini tubdan o‘zgatish qisman yoritilgan. Bunda qo‘yilgan asosiy talab yosh avlodning ilmiy dunyoqarashini va intellektual rivojlantirishni sifat jihatidan yangi darajaga ko‘tarish, tez o‘zgarayotgan dunyoga moslashishni o‘rgatishdan iboratdir. Shu bilan birga o‘quv-tarbiya jarayoniga ta’limning innovatsion shakllari va usullarini joriy etishga qaratilgan.
High-rate real-time single-frequency PPP for structural motion detection in horizontal directions
Authors: Bezcioglu Mert , Karadeniz Baris , Yigit Cemal Ozer , Dindar Ahmet Anil , Akpinar Burak 
Published: January 2023

Thanks to advances in receiver and software technology, the high-rate GPS (Global Positioning System) technique has become very important in monitoring the dynamic behavior of man-made structures in both real-time and post-missions. Real-time monitoring of the changes in the behavior of structures due to effects such as natural disasters, wind effect, traffic loading is critical in order to take precautions in time. In this study, the performance of the Real-Time Single Frequency Precision Point Positioning (RT SF-PPP) method based on IGS (International GNSS Service) RTS (real-time stream) products to capture the behavior of dynamic motions was evaluated. The performance of the SF RT-PPP method to detect dynamic behaviors was evaluated based on 20 Hz single frequency GPS observations obtained from shake table experiments, including 10 mm amplitude and different oscillation frequencies including 0.1, 0.6, 1.0, 2.0 and 3.0 Hz. RT SF-PPP results were compared with reference LVDT (Linear Variable Differential Transformer) and relative (or double difference) GPS positioning both frequency and time domain. Results show that the high-rate RT SF-PPP method can capture the frequencies and amplitudes of harmonic motions and it is comparable to LVDT and Relative GPS positioning solutions. These results show that the high-rate RT SF-PPP method can monitor earthquake-induced real-time vibration frequencies and amplitudes, which is especially important for early warning systems.
Using Practice-Based Inquiry to Enact Occupation-Centered, Justice-Oriented Practice in an Acute Mental Health Setting
Authors: Gallagher MaryBeth , Bagatell Nancy , Godwin Kimberly , Peters Darren 
Published: January 2023

AbstractImportance: Occupational therapy practitioners working in mental health settings in the United States are faced with challenges and barriers to implementing justice-oriented, occupation-centered practice. Research situated in the practice context with practitioners as coresearchers may provide an avenue for changing practice.Objective: To describe the reconceptualization and redesign of occupational therapy services by a community of occupational therapy practitioners in an acute mental health setting in the United States.Design: Practice-based inquiry, a form of practitioner-generated action research with a community of practice scholars (CoPS), guided the redesign of practice.Setting: Acute mental health service in a large teaching hospital system.Participants: Nine occupational therapists comprised a CoPS and served as coresearchers and participants in the study.Data Collection and Analysis: Practitioner scholars’ experiences of daily practice captured in individual reflections and collective research discussions were the source of data. Data collection, analysis, and action was an iterative process. Coresearchers coded and categorized findings and then developed themes reflecting changes enacted in practice.Findings: The data analysis resulted in two themes characterizing how the CoPS reconceptualized and redesigned practice to reflect their commitment to occupation-centered and justice-focused occupational therapy: (1) occupational opportunities through direct services and (2) occupational opportunities through system-level change.Conclusions and Relevance: For this CoPS, engaging in a practice-based inquiry facilitated a reconceptualization of their practice and widened their occupational lens, thus strengthening their identity as occupational therapists. Given the barriers to demonstrating occupational therapy’s unique contribution to mental health practice, this research provides a valuable tool for practitioners.What This Article Adds: Occupational therapy practitioners who engage in context-specific, action-oriented research experience a transformative process that empowers them to address barriers often encountered in mental health practice and enact occupation-centered and justice-focused practice.
Engineering and Financial Feasibility of Residential Housing Using Greenship Rating Tool Parameters
Authors: Setiono Joko , Rochman Taufiq 
Published: January 2023

Green building aims to reduce environmental effect by improving indoor air quality for households and the community. Green buildings use the Greenship Rating Tools evaluation standards to accomplish environmentally sustainable residential development. Purpose of the study: The most important part of this thesis is to do a engineering and financial preliminary study before the construction of houses. Methods: Three home types (48/66, 70/84, and 80/112) will be used to generate Malang Residential Home data for this project. On the basis of BBC, BFC, and GBC, the technical viability will be assessed. The NPV, BCR, IRR, and PBP will be utilized to establish the project's financial viability. Variations in capital proportion, as well as increases or decreases in project revenue and outcome, would all be included when calculating sensitivity. Results: Between 60% and 75% of the BBC's technical feasibility has been determined, whereas BFC is between 0.60 and 1%, and GBC is larger than 10%. To put Malang Residential Housing in the silver level, IDR 1,382,745,228 was the NPV, with a BCR of 1.02, an IRR of 59.75 percent, and a PBP of one year and six months. It was concluded that the project was viable based on the sensitivity of the project's income and results to its viability.
Keywords: Greenship Rating Tool, Engineering Feasibility, Financial Preliminary Study
Solar Charger Controller Efficiency Analysis of Type Pulse Width Modulation (PWM) and Maximum Power Point Tracking (MPPT)
Authors: Faizal Elka , Winoko Yuniarto Agus , Mustapa Mohammad Sukri , Kozin Muhammad 
Published: January 2023

Solar radiation at any time can be different due to various things such as blocking of sunlight due to clouds, the intensity of the sun from sunrise to sunset, cloudiness in the rainy season, and the presence of fog in certain areas which causes different levels of solar energy. radiation that causes the output power of solar cells to vary. and not optimal. For that we need a control device that can stabilize the energy output from solar cells called Solar Charge Controller (SCC). This research was conducted to determine the value of the output power, voltage, and current of SCC type Type Pulse Width (PWM) and Maximum Power Point Tracking (MPPT), then determine the value of efficiency, and compare which type of SCC is better to use. Sampling of solar voltage and current data in the field at 10.00 â€“ 15.00, this is because at that time the sunlight reaches its maximum intensity. The results showed that the MPPT type SCC efficiency was higher than the PWM type SCC efficiency value, namely 84.623% the MPPT type SCC efficiency compared to 80.935% PWM type SCC efficiency.
Keywords: Solar Charge Controller, Pulse Width Modulation, Maximum Power Point Tracking
Comparison Analysis of Equivalent Static Earthquake and Spectrum Response Dynamics on Steel Structure
Authors: Ningrum Diana , Nahak Albertus , Rasidi Nawir 
Published: January 2023

The purpose of this study is to compare two methods of seismic load analysis, namely the static equivalent method and the dynamic response spectrum method. The case study is the integrated service building of Tribhuwana Tunggadewi University, Malang City which has 5 levels and is located in the 4 (medium) earthquake zone with moderate soil conditions. The research method used is descriptive quantitative. Collecting data of project drawings, as well as observations and interviews. Analysis method Equivalent static and dynamic response spectrum using software Staad Pro. The results compared are the base shear force (V), the floor lateral force (F), and the displacement or displacement. The result in the form of maximum internal force is analyzed to determine the capacity or ability of the profile to withstand combined loads. The comparison of base shear and displacement does not differ much from the two seismic analysis methods used. This insignificant difference is in accordance with the SNI that for structures with a height below 40m can be analyzed using equivalent statics, while in the case study it only has a height of 30m. So that the equivalent static analysis becomes more accurate to use because the analysis process is simpler than dynamic analysis, but for structures with a height above 5 floors it is recommended to use dynamic analysis. The results of the analysis of the ability of the steel profile on the cross section of the column and beam indicate a safe condition in carrying combined loads.
Keywords: Volume Fraction, Cannabis Sativa Fibers, Fiber Composites
Lemborexant (Dayvigo)
Authors: CADTH  
Published: January 2023

CADTH recommends that Dayvigo not be reimbursed by public drug plans for the treatment of insomnia, characterized by difficulties with sleep onset and/or sleep maintenance.
Two clinical trials showed that, compared to placebo, Dayvigo resulted in improvements in the time it takes to fall asleep, the time spent awake after initially falling asleep, and the time spent sleeping divided by the total time spent in bed measured during sleep studies.
It was uncertain whether the effect of Dayvigo was enough to make a clinically meaningful improvement for the sleep outcomes measured using patients’ sleep diaries.
Based on the evidence reviewed, it is uncertain whether Dayvigo offers a meaningful clinical benefit over other treatments used for insomnia. There was not enough evidence to conclude that Dayvigo meets patients’ needs for a treatment with long-term effectiveness that results in uninterrupted and restorative sleep, less stress and anxiety, improved productivity, improved relationships, and fewer side effects compared to other treatments for insomnia. It was also unclear if patients receiving Dayvigo would be able to manage their sleep problems without becoming dependent on the medication.