bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extended mesenteric resection reduces the rate of surgical recurrence in Crohn’s disease: a systematic review and meta-analysis
Authors: Vaghiri Sascha , Alipouriani Ali , Knoefel Wolfram Trudo , Kessler Hermann , Prassas Dimitrios 
Published: February 2025

Abstract

Purpose
Mesenteric resection in Crohn’s disease (CD) is still controversial and under discussion. We performed a meta-analysis to assess recurrence rates and operative-related morbidity based on the extent of mesenteric resection.

Methods
A comprehensive literature research was conducted until November 2024 using PubMed (Medline), the Cochrane Central trials register, and Google Scholar databases. Studies before the biological era or with Kono-S anastomosis were excluded. Data from comparative studies with reported patient characteristics and outcome results of extended and limited mesenteric resections were extracted and subsequently entered into a pairwise meta-analysis model. Odds ratios (ORs) for dichotomous variables and standardized mean differences (SMDs) for continuous outcomes with 95% confidence intervals (CIs) were calculated. The risk of bias was rated according to ROBINS-I and Rob2 criteria, respectively.

Results
Four non-randomized studies and one randomized trial with a total of 4358 patients (extended mesenteric resection: n = 993 versus mesenteric preservation: n = 3365) met eligibility criteria and were included. Extended mesenteric resection was significantly associated with reduced surgical recurrence rates compared to mesenteric preservation (OR = 4.94; 95% CI [2.22–10.97]; p < 0.001, I
2 = 0%). In terms of endoscopic recurrence, postoperative morbidity, and hospital stay, no significant differences between both groups were noted within the short follow-up period.

Conclusion
Extended mesenteric resection demonstrated a lower surgical recurrence rate in Crohn’s disease, while morbidity rates were comparable to the mesenteric sparing approach, whether extended mesenteric excision should be recommended requires further high-quality randomized trials with long-term follow-up data.
Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial
Authors: Hayes Eleanor , Alhulaefi Shatha , Siervo Mario , Whyte Eleanor , Kimble Rachel , Matu Jamie , Griffiths Alex , Sim Marc , Burleigh Mia , Easton Chris , Lolli Lorenzo , Atkinson Greg , Mathers John C. , Shannon Oliver M. 
Published: February 2025

Abstract

Purpose
Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Inter-individual differences in these responses are suspected but have not been investigated using robust designs, e.g., replicate crossover, and appropriate statistical models. We examined the within-individual consistency of the effects of dietary nitrate supplementation on NO biomarkers and BP, and quantified inter-individual response differences.

Methods
Fifteen healthy males visited the laboratory four times. On two visits, participants consumed 140 ml nitrate-rich beetroot juice (~ 14.0mmol nitrate) and, on the other two visits, they consumed 140 ml nitrate-depleted beetroot juice (~ 0.03mmol nitrate). Plasma nitrate and nitrite concentrations were measured 2.5 h post-supplementation. BP was measured pre- and 2.5 h post-supplementation. Between-replicate correlations were quantified for the placebo-adjusted post-supplementation plasma nitrate and nitrite concentrations and pre-to-post changes in BP. Within-participant linear mixed models and a meta-analytic approach estimated participant-by-condition treatment response variability.

Results
Nitrate-rich beetroot juice supplementation elevated plasma nitrate and nitrite concentrations and reduced systolic (mean:-7mmHg, 95%CI: -3 to -11mmHg) and diastolic (mean:-6mmHg, 95%CI: -2 to -9mmHg) BP versus placebo. The participant-by-condition interaction response variability from the mixed model was ± 7mmHg (95%CI: 3 to 9mmHg) for systolic BP and consistent with the treatment effect heterogeneity t = ± 7mmHg (95%CI: 5 to 12mmHg) derived from the meta-analytic approach. The between-replicate correlations were moderate-to-large for plasma nitrate, nitrite and systolic BP (r = 0.55 to 0.91).

Conclusions
The effects of dietary nitrate supplementation on NO biomarkers and systolic BP varied significantly from participant to participant. The causes of this inter-individual variation deserve further investigation. Trial registration: https://clinicaltrials.gov/study/NCT05514821.
3D Master-based Method for Optimizing the Cost Calculation of PBF-LB/M Manufactured Parts
Authors: Lanfant Briac , Lack Silvan , Meyer Benjamin , Abdulkadir Ahmed , Stadelmann Thilo , Schmid Daniel 
Published: February 2025

Abstract
The 3D Master method streamlines the transfer of product information from design to production, utilizing 3D model files containing Product Manufacturing Information. This approach facilitates direct access to crucial data like materials, geometric dimensions, and tolerances for each step of the metal additive manufacturing (MAM) of parts. By leveraging this data, the 3D Master method enables the automation of accurate cost evaluation.
This contribution introduces a method leveraging the 3D Master to automate a precise manufacturing cost calculation for MAM parts using powder-based fusion processes. It proposes a frame based on the quality level of the data provided by the customer to quantify the accuracy of the estimated cost, thanks to a performance index (KPI). A build cost model based on an optimal volumetric energy density calculation achieved through a theoretical and statistical approach is also provided. The study, conducted on 20 reference MAM parts of varying geometrical complexities, demonstrates a relative deviation of normalized actual and calculated cost difference below 10%.
This cost model and the KPI give solid foundations for a service provider to assess the production cost at the early stages of the production process and lay the groundwork for a commercial online service platform offering reliable and adapted quotes for MAM part production within minutes.
Accelerating NVH optimization of eMBS system models through efficient parallelization of transient runup simulations
Authors: Müller Julius , Jacobs Georg , Wischmann Stefan , Höpfner Gregor 
Published: February 2025

Abstract
The modern, ever shorter development process of electrified drivetrains requires methods that enable a sufficiently fast acoustic evaluation of design decisions. The dynamic and acoustic behavior (NVH) forms a crucial aspect for the consumer’s purchase decision. Since experimental and empiric optimization approaches are highly inefficient, simulation methods such as the elastic multi-body simulation (eMBS) are used to sufficiently simulated the NVH-behavior of the drivetrain by performing transient run-up simulations. However, these simulations are highly computationally intensive, leading to computational times of multiple days or weeks, thus making those optimization approaches inefficient during iterative phases of the development process. Therefore, there is a need to reduce the overall simulation time for eMBS-based evaluation of design decisions.
This publication proposes a method on how to parallelize transient runup simulations to significantly decrease the needed simulation time for eMBS simulations. In this process, a partition of the time domain is achieved by analytically calculating the kinematic states of individual components at discrete time steps. As a result, a multitude of runup partitions can be computed in parallel, leading to a drastic reduction in simulation time. This method is demonstrated by examining an electrified powertrain. The application of the method shows a reduction in simulation time for a transient drivetrain runup of over 90%. The validation is carried out by comparing the parallelized computational results to a conventional transient simulation of the electrified drivetrain. Based on the proposed method the engineer is capable to efficiently use detailed eMBS system models within highly iterative phases of a development process for the evaluation of design decisions and therefore address NVH-optimizations more sufficiently.
The Boosted Double-proximal Subgradient Algorithm for nonconvex optimization
Authors: Aragón-Artacho Francisco J. , Pérez-Aros Pedro , Torregrosa-Belén David 
Published: February 2025

Abstract
In this paper we introduce the Boosted Double-proximal Subgradient Algorithm (BDSA), a novel splitting algorithm designed to address general structured nonsmooth and nonconvex mathematical programs expressed as sums and differences of composite functions. BDSA exploits the combined nature of subgradients from the data and proximal steps, and integrates a linesearch procedure to enhance its performance. While BDSA encompasses existing schemes proposed in the literature, it extends its applicability to more diverse problem domains. We establish the convergence of BDSA under the Kurdyka–Łojasiewicz property and provide an analysis of its convergence rate. To evaluate the effectiveness of BDSA, we introduce two novel test functions with an abundance of critical points. We conduct comparative evaluations, including algorithms with inertial terms, that illustrate its ability to effectively escape non-optimal critical points. Additionally, we present two practical applications of BDSA for testing its efficacy, namely, a constrained minimum-sum-of-squares clustering problem and a nonconvex generalization of Heron’s problem.
Developing configurations and solutions for logical puzzles with UML and OCL
Authors: Gogolla Martin , Sánchez Cuadrado Jesús 
Published: February 2025

Abstract
Logical puzzles can be important factors for the development of rational analysis and application capabilities for pupils and students. Therefore, logical puzzles can also take a prominent supporting role in computer science education. This contribution proposes a UML class model with accompanying OCL constraints for developing logical puzzles. The class model acts as a metamodel for the description of the basic puzzle organization and the logical clues presented to the learners. The constraints express, for example, statements about uniqueness of solutions, and the degree of puzzle complexity may be tuned by appropriate model elements. Given a puzzle specification which simply comprises the domain elements of the puzzle plus constraints, our implementation uses a UML and OCL solver to construct a puzzle instance (i.e., a set of clues and solutions) automatically. The puzzle is made playable by a graphical user interface. We have validated this approach for developing puzzles by building several puzzles from the literature of increasing complexity and performed a student survey.
Prevalence of Social Determinants of Health Risk Factors Among and Their Impact on Viral Suppression, Consistent Visits, and No-Show Rates Among Persons with HIV Who Identify as Hispanic
Authors: Cowden Mary , Clavijo Ana , Bitar Yanis , Diaz Monica , Merced Xiomara , Meza Karla , Iyengar Pragnya , Avery Ann 
Published: February 2025

Abstract
The current study examines the association between language preference, social determinants of health (SDOH) risk factors, viral load, and HIV care outcomes among individuals of Hispanic ethnicity in the United States. More than half (54%) of all participants reported having two or more unmet needs. Hispanic individuals were more likely to be at risk in 2 or more domains than their non-Hispanic counterparts. Food insecurity was the most common risk factor reported and when present, 51% of patients also reported financial resource strain. Surprisingly, when language preference was analyzed, English-preferring Hispanic patients were at higher risk of financial resource strain, daily stress, and food insecurity compared to those who preferred Spanish. When accounting for birthplace, Hispanic patients born in the US reported higher rates of daily stress, food insecurity, and unavailable transportation compared to Hispanic patients born in Puerto Rico or elsewhere outside the US. Increased SDOH risk factors including financial resource strain, housing and utilities strain, and limited transportation access were significantly associated with higher rates of no-shows to HIV clinic appointments but not with increased viral load or consistent completed clinic visits. In a mixed-effects model, each additional at-risk domain correlated to a 0.198 increase in the no show rate. This model also demonstrates higher rates of no-show visits in English-preferring Hispanic patients compared to Spanish-preferring patients. Overall, SDOH risk factors were commonly reported in our population and their presence were associated with higher no-show rates but not with viral suppression.
On the existence of an extremal function for the Delsarte extremal problem
Authors: Ramabulana M. D. 
Published: February 2025

Abstract
In the general setting of a locally compact Abelian group G, the Delsarte extremal problem asks for the supremum of integrals over the collection of continuous positive definite functions

$$f \colon G \to \mathbb{R}$$

f
:
G
→
R

satisfying

$$f(0) = 1$$

f
(
0
)
=
1

and having

$$supp f_{+} \subset \Omega$$

s
u
p
p

f
+

⊂
Ω

for some measurable subset

$$\Omega$$

Ω

of finite measure. In this paper, we consider the question of the existence of an extremal function for the Delsarte extremal problem. In particular, we show that there exists an extremal function for the Delsarte problem when

$$\Omega$$

Ω

is closed, extending previously known existence results to a larger class of functions.
Possible Differences in Visual Attention to Faces in the Context of Mate Choice and Competition
Authors: Pátková Žaneta , Grygarová Dominika , Adámek Petr , Třebická Fialová Jitka , Havlíček Jan , Třebický Vít 
Published: February 2025

Abstract
Existing research indicates that the shape of various facial regions is linked to perceived attractiveness and perceived formidability. Interestingly, little evidence shows that people directly focus on these specific facial regions during judgments of attractiveness and formidability, and there is little support for the notion that the levels of attractiveness and formidability affect raters’ visual attention. We employed eye-tracking to examine visual attention (the number of fixations and dwell time) in 40 women and 37 men, while they assessed 45 male faces in life-sized photographs for attractiveness and formidability. The facial photographs were grouped by varying levels of attractiveness and formidability (low, medium, and high). Our results showed that regardless of the characteristics rated, both men and women paid the most visual attention to the eyes, nose, mouth, and forehead regions. We found statistically discernible variation in visual attention in relation to the rater’s sex or target’s attractiveness levels for other facial features (the chin, cheeks, or ears), but these differences may not be substantial enough to have practical implications. We suggest that the eyes, the nose, and the mouth regions play a central role in the evolution of face perception as regions most salient to the acquisition of informative cues about others. Further, during both attractiveness and formidability judgments, men looked longer at the stimuli than women did, which may hint at increased difficulty of this task for men, possibly because they compare themselves with the stimuli. Additionally, irrespective of sex, raters looked marginally longer at faces with a medium level of formidability than at those with a high formidability level, which may reflect ambiguity of these stimuli and uncertainty regarding assessment. We found no other significantly relationships between the target’s attractiveness and formidability levels and the rater's visual attention to whole faces.
Disorder Type and Severity as Predictors of Mental Health in Siblings of Children with Chronic Disorders
Authors: Fredriksen Trude , Orm Stian , Prentice Caitlin M. , Kirchhofer Solveig , Zahl Erica , Botta Matteo , Vatne Torun M. , Fjermestad Krister W. 
Published: February 2025

Abstract
Siblings of children with chronic disorders are at risk of developing mental health problems. Studies are inconclusive about whether sibling mental health is best predicted by the specific diagnoses of the child with disorder or by transdiagnostic factors. The aims of the present study were (1) to examine if specific diagnoses predicted sibling mental health, and (2) to examine if disorder severity in the child with the chronic disorder predicted sibling mental health. Baseline data from a randomized controlled trial were used. Siblings (aged 8 – 16 years) of children with chronic disorders and their parents were recruited from eight municipality and hospital clinics (N = 288). The children with chronic disorders were placed in ICD-10 diagnostic categories based on combined parent report and clinical records. Regression analyses with the most frequent primary diagnoses (ADHD, Asperger syndrome, autism, down syndrome, rare disorders) and a measure of disorder severity as predictors of sibling mental health were run. Father-reported disorder severity predicted sibling-reported internalizing problems and father-reported internalizing and externalizing problems in siblings. Mother-reported disorder severity predicted mother-reported sibling internalizing problems. No single primary diagnosis predicted sibling internalizing or externalizing problems. Disorder severity does to an extent predict sibling mental health, whereas single diagnostic categories do not. Disorder severity may be used to identify siblings at risk and/or in need of interventions. Fathers should be included in assessment and health care for siblings as their reports seem to predict sibling mental health better than the mothers.
Improving the evaluation of static bifurcations in locally damaged parabolic arches
Authors: Eroğlu U. , Ruta G. , Tüfekci E. , Paolone A. 
Published: February 2025

Abstract
Even local small cracks may induce instability and failure or operativity loss before the crisis for the intact material is actually attained. Thus, damage models and the possibility of their identification have become trendy subjects in structural mechanics. We previously studied buckling and post-buckling of parabolic arches with a local transverse small crack by two perturbations of the finite field equations and boundary conditions. One perturbation describes non-trivial fundamental paths adjacent to the undamaged initial shape, the second describes the germ of a bifurcated path in the vicinity of a critical point. We think the arch consisiting of two undamaged parts, connected by lumped elasticities quantified by notions of linear fracture mechanics, at the cracked cross-section. In this paper we highlight that in a previous investigation of ours on the same subject some physically meaningful terms were wrong in the perturbed equations. This implies that the values of the incremental external load considered in the applications of that investigation need to be amended. Thus, here we present perturbed equations that are complete and, by the same procedure, we find more reliable numerical results for the critical loads and a more refined description of the germ of the post-buckling path, besides providing clear physical interpretation for seemingly paradoxical results.
Cognizing the vital principle of the organism by interpreting the four Aristotelian causes in a Kantian perspective: an outline
Authors: Hueck Christoph J. 
Published: February 2025

Abstract
This article outlines an epistemological perspective to understand the organism as a temporally changing whole. To analyze the mental faculties involved, the organism’s development and persisting existence is differentiated into four interdependent aspects: descent, future existence, persistent species, and environmentally adapted physical appearance. It is outlined that these aspects are recognized by comparative memory, concept-guided anticipation, conceptual thinking, and sensory perception, respectively. Furthermore, it is pointed out that these aspects correspond to the famous four Aristotelian “causes” or principles of explanation. The descent of an organism corresponds to Aristotle’s efficient principle (“where does it come from?”), its future existence to the final principle (“what is if for?”), its physical structure to the material principle (“out of what is it?”) and its persistent species to the formal principle (“what is it?”). Aristotle regarded the unity of the efficient, formal and final principle as the ontological cause of the organism and called it the “soul” (psyche), while the material principle can be understood to represent its “body” (soma). I suggest that Aristotle’s “soul” corresponds to three of the four mental faculties required for cognition of a self-maintaining organism. I argue that in a Kantian perspective, the Aristotelian “soul” represents the condition of the possibility of recognizing an organism at all. Therefore, the Aristotelian principle of life becomes intelligible and even empirically observable through the inner sense. In summary, I suggest that the four aspects of the organism described here can be viewed as the general, epistemological and ontological principle of the organism, the Bio-Logos.
Synthesis of Enantiopure Beta-Blocker (+)-Nebivolol by Enzyme Catalyzed Asymmetrization Reaction
Authors: Bjørnes Fredrik , Aasen Sara , Makosa-Szczygiel Marcin Krzysztof , Thieffry Zoe Palmyre , Lefebvre Juliette , Hoem Eline Flo , Jacobsen Elisabeth Egholm 
Published: February 2025

Abstract
A six-step synthesis to (+)-nebivolol ((S,R,R,R)-nebivolol or d-nebivolol) in a cumulative yield of 32% has been developed. Conventional use of diazo compounds has been replaced with a novel approach of sulphur ylide for a safer one-carbon chain extension of methyl 6-fluorochromane-2-carboxylate, which entailed the formation of racemic 2-[dimethyl(oxido)-λ6-sulfanylidene]-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethenone from methyl 6-fluorochromane-2-carboxylate in high yield. Subsequently the β-keto sulfoxonium ylide was converted into 2-chloro-1-(6-fluorochroman-2-yl)ethanone. Reduction of 2-chloro-1-(6-fluorochroman-2-yl)ethanone to 2-chloro-1-(6-fluorochroman-2-yl)ethanol was catalyzed by Ketoreductase 228 from Syncozymes and resulted in halohydrins (R)-2-chloro-1-((S)-6-fluorochroman-2-yl)ethanol and (S)-2-chloro-1-((S)-6-fluorochroman-2-yl)ethanol in 92% yield. The halohydrins were separated by preparative HPLC. (S)-2-Chloro-1-((S)-6-fluorochroman-2-yl)ethanol underwent amination to produce (R)-2-amino-1-((S)-6-fluorochroman-2-yl)ethanol. The final synthesis step involved reaction of (R)-2-amino-1-((S)-6-fluorochroman-2-yl)ethanol and (R)-2-chloro-1-((S)-6-fluorochroman-2-yl)ethanol forming (+)-nebivolol with > 99% enantiomeric excess (ee).