bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practices and perspectives of genetic counselors about high‐risk pancreatic cancer screening: A cross‐sectional survey study
Authors: Wiegand Amy , Chhoda Ankit , Namboodiri Aparna , Grimshaw Alyssa A. , Dalela Disha , Farrell James 
Published: January 2025

AbstractSurveillance of individuals at high‐risk of pancreatic cancer using CAPS criteria and other expert consensus guidelines may result in earlier pancreatic cancer detection in some cases; therefore, clinicians are responsible for appropriately identifying and referring these individuals to appropriate high‐risk pancreas cancer screening programs. This study aimed at assessing the perspective, knowledge, and clinical practices of cancer genetic counselors surveyed nationwide towards identification of individuals at high‐risk of pancreatic cancer and utilization of high‐risk pancreatic cancer screening programs. One hundred and eighty‐nine genetic counselors who listed “Cancer” as their specialty on the NSGC website responded to the survey, which consisted of multiple practice‐based, knowledge‐based, and clinical vignette‐based questions. Almost 70% of the genetic counselors surveyed accurately identified when an individual would be considered for high‐risk pancreatic cancer screening, when using 2019 CAPS consensus guidelines as a benchmark. Access to high‐risk pancreatic cancer screening programs and increased provider comfort in counseling individuals at high‐risk of pancreatic cancer were found to be statistically associated in accurate identification of high‐risk individuals in three of the clinical vignettes. Additionally, 60% of genetic counselors reported the majority of high‐risk individuals accept a referral for pancreatic cancer screening, which shows a high uptake of patients accepting referrals from genetic counselors. Genetic counselors have high accuracy in determining who is eligible for high‐risk pancreas screening; thus, they are the ideal providers for initiating referrals to high‐risk pancreatic cancer screening programs. Genetic counseling programs and high‐risk pancreatic cancer screening programs should establish a close working relationship to optimize the identification and subsequent referrals of high‐risk individuals eligible for pancreas cancer screening.
Longitudinal Follow‐Up of the Specific Antibody Response to SARS‐CoV‐2 Vaccination in Colombia
Authors: Arévalo‐Herrera Myriam , Rincón‐Orozco Bladimiro , González‐Escobar John Mario , Herrera‐Arévalo Sonia Marcela , Carrasquilla‐Agudelo Elena , Serna‐Ortega Paula Andrea , Quiceno‐García Sebastián , Palacio‐Muñoz Nicolas , Rosero‐López Brandon , Mondol‐Miranda Ernesto , Freyle‐Roman Ivette , Mendoza‐Landinez Brayan , Mora‐Guevara Eliana , Santos‐Barbosa Juan Carlos , Bohórquez‐Martínez Francisco , Bolaños‐Cristancho Natalia , Jiménez‐Serna Mónica , Nieto‐Rojas María A. , Suarez‐Zamora David , Quintero‐Espinosa Juliana , Londoño‐Trujillo Darío , Herrera‐ Valencia Sócrates 
Published: January 2025

ABSTRACTA total of 5011 adult volunteers attending vaccination centers in different regions of Colombia were enrolled in a 1‐year prospective observational cohort study to evaluate the immunogenicity and effectiveness of SARS‐CoV‐2‐based vaccines as part of a National Vaccine Program established to contain the COVID‐19 pandemic. Following informed consent, 5,011 participants underwent a sociodemographic survey and PCR testing to assess SARS‐CoV‐2 infection. Blood samples were collected, and serum fractions were obtained from a participant subsample (n = 3441) at six‐time points to assess virus‐specific IgG responses to the Spike protein, its Receptor Binding Domain, and the Nucleoprotein by ELISA. Additionally, antibody‐neutralizing activity was evaluated using a cPass SARS‐CoV‐2 neutralization kit. Most participants (95.8%; n = 4802) received between one Ad26. COV2.S (Janssen vaccine) and four vaccine doses of BNT162b2 (Pfizer/BioNTech), AZD1222 (AstraZeneca), mRNA‐1273 (Moderna), CoronaVac (Sinovac), with some receiving vaccine combinations; a small group, 4.2% (n = 209), remained unvaccinated. Throughout the study, only 8.76% (n = 439) of the participants tested positive for SARS‐CoV‐2 by PCR. Notably, all participants seroconverted for IgG antibodies, with high seropositivity rates for S (99.8%; n = 4795), RBD (99.7%; n = 1691), and N (92.7%; n = 3072) proteins. Moreover, significant (92%–97%) neutralizing activity was observed for all four SARS‐CoV‐2 circulating variants. This study highlights the importance of assessing the duration of the IgG response to SARS‐CoV‐2 elicited by vaccination and infection, and the antibody neutralizing activity as a potential surrogate marker of protection. These findings provide important insight for further strengthening the vaccination strategies to control COVID‐19.
Associations Between the Neural Stress Response and Symptoms of Anxiety and Depression
Authors: Giglberger Marina , Peter Hannah L. , Henze Gina‐Isabelle , Bärtl Christoph , Konzok Julian , Kirsch Peter , Kudielka Brigitte M. , Kreuzpointner Ludwig , Wüst Stefan 
Published: January 2025

ABSTRACTAnxiety and depression disorders show high prevalence rates, and stress is a significant risk factor for both. However, studies investigating the interplay between anxiety, depression, and stress regulation in the brain are scarce. The present manuscript included 124 law students from the LawSTRESS project. Anxiety and depression symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS), and psychosocial stress was induced with the imaging stress paradigm ScanSTRESS. Anxiety, but not depression scores, were significantly related to neural stress responses in a striato‐limbic cluster. Moreover, relative to women, men showed stronger associations between anxiety scores and activation in striatal and temporal clusters. A bifactor model of the HADS suggested a general factor characterized by tension, nervousness, and cheerlessness, which was associated with activation changes in a similar but more circumscribed cluster than anxiety. In the LawSTRESS project, the HADS was assessed at five sampling points (1 year, 3 months, 1 week prior exam, 1 week, and 1 month thereafter), and thus an exploratory trajectory analysis could be performed. It confirmed the relationship between anxiety scores and striatal stress responses at baseline but revealed no predictive value of the neural measure across the sampling points. Our results suggest that—in healthy young participants—neural acute psychosocial stress responses in striato‐limbic structures are associated with anxiety, supporting the assumption that these regions are related to individual differences in vulnerability to stress‐related disorders. A correlation with depression scores could not be found, and possible explanations are discussed.
What Could Go Wrong? Anxiety Fuels, but Optimism Buffers Negative Counterfactual Divergent Thinking
Authors: Kapoor Hansika , Rezaei Sarah , Mahadeshwar Hreem , Kaufman James C. 
Published: January 2025

ABSTRACTAnxiety‐driven counterfactual thinking can be a slippery slope. Building on the premise that both positive and negative emotions can impact creativity, the present study examines how trait anxiety, optimism, and other mental health factors like therapy experience shape outputs in divergent thinking (DT) tasks. Using an online sample (N = 647), the study introduces counterfactual DT tasks, where participants are prompted to respond to how a situation can either go in their favor (positive) or against it (negative). Participants generated more original responses in the positive counterfactual DT task versus the negative one; however, they generated a higher number of ideas in the negative task compared to the positive one. Both counterfactual tasks led to higher originality and fluency as compared to a real‐world DT task. Trait anxiety, especially when combined with past therapy experience or a previous mental health diagnosis, increased the number of negative counterfactual ideas. In contrast, optimism acted as a protective factor, enabling fewer ideas in the negative counterfactual task when combined with past therapy experience or a past mental health diagnosis. Our study challenges the binary view of emotional influences on creativity, highlighting the role of individual differences and experiences in shaping creative outputs. Diversifying the counterfactual DT tasks and using more refined measures of rumination and mental health history can provide further nuance to this line of research between creativity and anxiety.
Bone and Nerve Response to Sciatic Compression Neuropathy in a Rabbit Model
Authors: Fringuello Anthony R. , Kurtzman Joey S. , Hayes Westley , Carter John , Koehler Steven M. 
Published: January 2025

ABSTRACTCompression neuropathy is a prevalent medical condition, including common types such as carpal tunnel syndrome, cubital tunnel syndrome, sciatica, and many others. While the neurological consequences are well understood, the effects on bone properties and the potential downstream impact on fracture risk remain less clear. This study aimed to assess the influence of compressive neuropathy on bone properties using a rabbit model of sciatic nerve compression. We hypothesized that compressive neuropathy could adversely alter bone properties. Five New Zealand white rabbits underwent surgery to induce perineural scarring in the sciatic nerve, with the contralateral limb serving as a sham control. Bone mineral density (BMD), mechanical strength, and bone signaling proteins were evaluated through microcomputed tomography (μCT), four‐point bending tests, and ELISA assays, respectively. Sciatic nerve histology was analyzed using VEGF and Nissl staining to assess axon and Schwann cell densities and quantified using image analysis software. The results showed no significant differences in BMD, biomechanical properties, or key bone signaling proteins (OPG and RANKL) between the affected and control tibias. These findings suggest that compression neuropathy does not significantly impact bone properties in the rabbit model.
ICD‐11 posttraumatic stress disorder (PTSD) and complex PTSD in a sample of prison staff: A latent profile approach
Authors: Dhingra Katie , Boyda David , Mitchell Sean M. , Taylor Peter J. 
Published: January 2025

AbstractAlthough empirical support for the International Statistical Classification of Diseases and Related Health Problems (11th ed.; ICD‐11) distinction between posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) is growing, research into the ICD‐11 CPTSD model in prison staff is lacking. This study used latent profile analysis (LPA) to (a) determine if there are distinct groups of trauma‐exposed prison governors (i.e., “wardens” in the United States and Canada) who have symptom profiles consistent with the distinction between PTSD and CPTSD and (b) identify predictors and posttraumatic maladaptive beliefs associated with the latent profiles. Trauma‐exposed prison governors (N = 385) completed the International Trauma Questionnaire (ITQ) and a measure of traumatic life events. LPA was used to extract profiles using the six ITQ symptom clusters and revealed four profiles: CPTSD (8.4%), PTSD (14.4%), disturbances in self‐organization (DSO; 11.0%), and low symptoms (66.3%). Membership in the CPTSD and DSO profiles was associated with cumulative traumatization, odds ratios (OR) = 1.42 and OR = 1.26, respectively, and poorer health, OR = 2.84 and OR = 1.64, respectively, relative to the low symptom profile, and membership in the PTSD profile was associated with younger age, OR = 0.91, relative to the low symptom profile. The CPTSD profile showed the highest level of posttraumatic maladaptive beliefs. This study yields empirical support for the ICD‐11 CPTSD model in prison staff. The results provide additional support for the validity of ITQ measurement of PTSD and CPTSD.
Superbly Bright Tin‐Based Perovskite LEDs
Authors: Miao Zeyu , Guo Jie , Jiang Dan , Zheng Weijia , Yin Wenxu , Luo Zhao , Zhou Xinyan , Jiang Zhou , Zhang Wei , Zhang Xiuyun , Chen Cong , Dai Xingliang , Dong Qingfeng , Yang Xuyong , Wang Ning , Wu Tom , Zhang Xiaoyu , Zhang Jiaqi 
Published: January 2025

AbstractTin (Sn)‐based perovskites have made notable advances with external quantum efficiency of over 20%, but still exhibit low electroluminescence brightness insufficient for outdoor displays. Here, it is demonstrated that compact phenethylammonium tin iodide (PEA2SnI4) films with an intact crystal structure can offer high luminance by optimizing the perovskite crystallization rate simultaneously with engineering the grain surface. Ammonium thiocyanate is added to the precursor solution to generate the film with PEA2SnIxSCN4‐x and NH4I after spin‐coating. Sn2+ and SCN− have a strong interaction that slows crystallization to improve PEA2SnI4 crystal quality. During the subsequent annealing, I− from NH4I replaces SCN− in PEA2SnIxSCN4‐x by forming thiourea, which can escape from the film to leave intact PEA2SnI4 crystals. It is found that the optimized PEA2SnI4 emitting layers can provide outstanding film coverage, high crystallinity, low trap state density, and superior photophysical performance. Consequently, an impressive brightness of 8285 cd m−2 for pure red electroluminescence is achieved, the first report of Sn‐based perovskite light‐emitting diodes that meet outdoor display requirements.
Material Point Method Modeling of Granular Flow Considering Phase Transition From Solid‐Like to Fluid‐Like States
Authors: Feng Hang , Liang Weijian , Yin Zhen‐Yu , Hu Liming 
Published: January 2025

ABSTRACTGranular flow is ubiquitous in various engineering scenarios, such as landslides, avalanches, and industrial processes. Reliable modeling of granular flow is crucial for mitigating potential hazards and optimizing process efficiency. However, the complex behavior of granular media, which transitions between solid‐like and fluid‐like states, poses a significant challenge in their modeling, particularly when involving rapid mobilization. To address this challenge, we propose an innovative constitutive model capable of capturing the highly nonlinear behavior of granular flow by integrating frictional and collisional mechanisms under varying states. The proposed model incorporates two distinct stress components: frictional stress and collisional stress. The frictional stress is governed by a critical‐state‐based elastoplasticity model, which accurately describes the solid‐like behavior of granular media. On the other hand, the collisional stress is formulated using a well‐established kinetic theory, which effectively captures the fluid‐like behavior of granular media. To seamlessly transition between these two states, we introduce a novel state variable, the granular temperature, which serves as a measure of the kinetic energy of the granular system. This innovative transition model is further incorporated into a GPU‐based material point method (MPM) and used to model two types of granular flows, including column collapse and flume test on an inclined surface. The numerical results show good agreement with available experimental data, highlighting the efficacy of our proposed phase transition model with the MPM modeling approach in effectively capturing the transition of granular materials from solid‐like to fluid‐like states throughout the mobilization process, from initiation to final deposition.
Effects of a Behavior Intervention Based on the Recurrence Risk Perception and Behavioral Decision Model for Ischemic Stroke Patients: A Randomized Controlled Trial
Authors: Zhang Jie , Zhang Zhenxiang , Lin Beilei , Jiang Hu , Mei Yongxia , Li Xin , Ma Ling 
Published: January 2025

ABSTRACTBehavioral management is essential to preventing recurrence after stroke, but its adherence is limited worldwide. We aimed to assess the impact of the behavior intervention based on the Recurrence risk perception and Behavioral decision Model for ischemic stroke patients' health behavior. This study was a single‐blind, randomized, controlled trial with a 3‐month follow‐up. The outcome measures were the perception of the risk of stroke recurrence, behavioral decision, and health behavior. A total of seventy participants were randomized to the intervention group (n = 35) or control group (n = 35). The former received a twelve‐week theory‐based intervention in addition to the routine education, while the control group received only the routine education. The generalized estimating equations results indicated that the intervention group had significantly greater improvements in perception of the risk of stroke recurrence compared to the control group at all T1 (B = 0.13, 95% CI: 0.03 to 0.23), T2 (B = 0.18, 95% CI: 0.07 to 0.28), and T3 (B = 0.16, 95% CI: 0.07 to 0.25) after adjusting for stroke frequency. Statistically significant improvements were found in behavioral decision for the intervention group compared with the control group at T2 (B = 0.25, 95% CI: 0.09 to 0.41) and T3 (B = 0.26, 95% CI: 0.10 to 0.43). Results also showed a significantly higher increase in health behavior at T1 (B = 0.29, 95% CI: 0.09 to 0.48) and T2 (B = 0.22, 95% CI: 0.04 to 0.40). The intervention can improve the perception of the risk of stroke recurrence, behavioral decision, and health behavior in ischemic stroke patients.ImplicationsThis study provides a reference point for promoting healthy behaviors in patients with ischemic stroke. A recurrence risk perception and behavioral decision model‐based intervention was deemed to be feasible and useful in practice.Patient or Public ContributionPatients and their caregivers agreed to participate in the study and shared their experiences of participating in research with us.
Exploring the Dark Side of the NGO Halo: Relating NGO Mission, Morals, and People to NGO Unethical Behavior
Authors: De Bruin Cardoso Isabel , Meyer Marco , Kaptein Muel 
Published: January 2025

ABSTRACTThis study explores why nongovernmental organizations (NGOs) engage in unethical behavior because of, and not despite, their perceived moral integrity. Contrary to expectations, we show how a glorified perception of moral integrity within NGOs can create blind spots for unethical behavior, a phenomenon termed the NGO halo effect. The NGO halo consists of people in NGOs glorifying the moral goodness of their organization's mission, morals, and people and prioritizing them over other considerations, the effect of which is unethical behavior. The relationship between the NGO halo and NGO unethical behavior has not been measured. We conduct two studies to measure the relationship between the NGO halo and NGO unethical behavior. In Study 1 (N = 256), we define and establish the content validity of the two NGO halo effect constructs. In Study 2 (N = 544), we validate the constructs and use a regression design to show that the NGO halo is positively and significantly related to unethical behavior. Our research reveals the dark side of moral idealization and confirms that the NGO halo effect is a risk factor for NGO unethical behavior.
Mitigating Effort Through Power: The Impact of Participant Power in Nonprofit Participatory Campaign Engagement
Authors: Kim E. , Kim Y. , Kang E. 
Published: January 2025

ABSTRACTThis study empirically demonstrates the effect of participant power within the framework of nonprofit campaigns, specifically examining its moderating role in mitigating the perceived effort required for participation. Two studies used a 2 (participation effort: high/low) × 2 (participant power: high/low) between‐subjects experimental design. Results indicate that when participant power was low, intentions to engage in nonprofit campaigns were lower among participants facing high participation effort compared with those facing low effort. Conversely, when participant power was high, no significant differences were observed based on the level of participation effort. This research sheds light on the nuanced dynamics of participant involvement in nonprofit campaigns, emphasizing the pivotal role of perceived power in influencing participation behaviors.
A Multilayer, Multimethod Web and Language Accessibility Analysis of US Nonprofit Organization Websites: Considerations for the Marketing and Promotion of Online Giving
Authors: Mason A. M. , Baldwin Lauren , Ahring Tatum 
Published: January 2025

ABSTRACTIn lieu of recent declines in individual giving to US nonprofits focused on social causes, education, environment, and animal welfare, this study examines the web and language accessibility of US nonprofit websites. By examining potential accessibility design barriers, we seek to understand whether US nonprofit organizations are limiting their outreach to online donors, specifically persons with disabilities (PwDs). Nonprofit websites were systematically and randomly sampled from Charity Navigator's Alphabetical Listing of the Top 1000 Most Visited Charities database. Using a multimethodological approach consisting of manual verification and computer‐automated analysis techniques, we assess the web and language accessibility of leading US nonprofit organization websites (n = 81). Quantitative analysis of web accessibility data reveals that a little more than 5% of US. nonprofit websites offer accessibility policy (AP) statements or tailored information to PwDs on the website home pages. Results show US nonprofit websites are laden with specific accessibility error types that are most likely to impact user experiences related to perceivability, operability, and understandability. These error types were also positively and moderately correlated across the home, donation, and contact pages within the websites. This study draws attention to the critical role of web and language accessibility in fulfilling stakeholder needs and advancing nonprofit missions. Discussion and limitations are provided.
Ethics and Efficacy: The Influence of Social Capital and Governance on Key Financial Metrics in Nonprofit Organizations
Authors: Mwaungulu Emmanuel , Stan Ciprian 
Published: January 2025

ABSTRACTThis study explores the influence of community‐level social capital on human behavior and its reflection on the practices and performance of nonprofit organizations. Drawing from social norms theory and utilizing a dataset of 327,020 nonprofit filings from 2011 to 2017, our findings reveal a positive and significant relationship between social capital and nonprofit performance metrics, specifically return on assets and program ratio. Further analysis examines the moderating role of nonprofit governance on these dynamics. This study adds to the extant body of literature by delineating the impact of community‐level social capital on nonprofits across critical financial indicators, offering nuanced insights into the interplay between social capital, governance, and organizational financial health.