bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances in MXenes Based Composites as Photocatalysts: Synthesis, Properties and Photocatalytic Removal of Organic Contaminants from Wastewater
Authors: Kitchamsetti Narasimharao , de Barros Ana L. F. 
Published: July 2023

AbstractMXene has indeed gained significant attention in recent years as a promising photocatalyst for various applications, including photocatalytic degradation of pollutants. MXene possesses several unique physical and chemical properties that make it suitable for such applications, including its uniform planar structure, strong metal conductivity, effective functional groups, and numerous derivatives. These properties contribute to the excellent photodegradation performance and long‐term stability exhibited by MXene‐based photocatalysts compared to other photocatalysts. MXene‐based composites, which are formed by incorporating MXene with other materials, demonstrate even better photodegradation activity due to their abundant active sites and porous structure. One crucial factor influencing the photodegradation performance of MXene‐based photocatalysts is the presence of active functional groups on the surface of MXene. These functional groups play a significant role in the photocatalytic process and contribute to the overall efficiency of the catalyst. To provide a broader understanding of MXene‐based photocatalysts, the physicochemical properties of MXene are briefly described in this review. This includes its structural characteristics, electrical conductivity, and the presence of functional groups. This review also investigates the physical and chemical synthesis routes for preparing MXene, both in its natural state and as composites with other materials. These synthesis methods are essential for tailoring the properties of MXene‐based photocatalysts to meet specific requirements. Finally, the review discusses future work and challenges in MXene‐based photocatalysis. This field holds great promise for addressing environmental concerns and improving the degradation of organic compounds. However, further research is needed to optimize the synthesis methods, enhance the photocatalytic efficiency, and explore the practical applications of MXene‐based photocatalysts.
Light‐Driven NADPH Cofactor Recycling by Photosystem I for Biocatalytic Reactions
Authors: Medipally Hitesh , Guarneri Alice , Pospisil Lars , Franssen Maurice C. R. , van Berkel Willem J. H. , Paul Caroline E. , Nowaczyk Marc M. 
Published: July 2023

AbstractBiocatalytic asymmetric reduction of C=C and C=O bonds is highly attractive to produce valuable (chiral) chemicals for the fine and pharmaceutical industry, yet occurs at the expense of reduced nicotinamide adenine dinucleotide coenzyme NADPH that requires recycling. Established methods each have their challenges. Here we developed a light‐driven approach based on photosystem I (PSI) by mimicking the natural electron transfer from PSI via ferredoxin (Fd) towards ferredoxin NADP+ reductase (FNR) in vitro. Illumination with red light led to reduction of NADP+ to NADPH with a turnover frequency of 2.55 s−1 (>9000 h−1) at pH 7.5. Light‐driven NADPH regeneration by PSI‐Fd‐FNR was coupled with three oxidoreductases for asymmetric reduction of C=C and C=O bonds, reaching up to 99 % conversion with a turnover number of 3035, and retaining enantioselectivity. This study demonstrates the capacity of a PSI system to drive continuous NADPH‐dependent biocatalytic conversions with light.
Computational Fluid Dynamics Simulation of a Membrane Contactor for CO2 Separation: Two Types of Membrane Evaluation
Authors: Sayyah Alborzi Zahra , Amini Younes , Amirabedi Parya , Raveshiyan Saba , Hassanvand Amin 
Published: July 2023

AbstractTwo different types of hollow‐fiber membrane contactors were used for CO2 separation from the gas stream with monoethanolamine (MEA) absorbent and numerically investigated. After the model validation with experimental data, CO2 removal efficiency, MEA concentration, and pressure drop variation were examined under different conditions by variation of some effective parameters such as gas stream velocity, absorption solution velocity, membrane porosity, and membrane tortuosity. Membrane tortuosity and porosity enhancement led to light decrease and light increase in CO2 removal efficiency, respectively, but gas stream velocity enhancement significantly reduced the CO2 removal efficiency.
Total Synthesis of UCS1025A via Tandem Carbonylative Stille Cross Coupling and Diels‐Alder Reaction†
Authors: Cui Chengsen , Dai Mingji 
Published: July 2023

Comprehensive SummaryWe report an efficient and convergent strategy for the total synthesis of UCS1025A and its diastereomer tetra‐epi‐UCS1025A. UCS1025A is a representative member of the naturally occurring pyrrolizidinone polyketides, from which members with potent antibacterial, antifungal, and anticancer activities have been identified. Our approach features a tandem carbonylative Stille cross coupling and Diels‐Alder reaction to forge a key C—C bond and build the trans‐decalin system. This tandem process utilizes carbon monoxide as a one‐carbon linchpin to stitch a vinyl triflate and a vinylstannane together and form the desired enone moiety for the subsequent intramolecular Diels‐Alder cyclization. Our synthesis also provides a versatile approach for the synthesis of other related pyrrolizidinone‐containing polyketides.
Mechanisms of change in treatments for transdiagnostic emotion dysregulation: The roles of skills use, perceived control and mindfulness
Authors: Wyatt Kristin P. , Eberle Jeremy W. , Ruork Allison K. , Neacsiu Andrada D. 
Published: July 2023

AbstractEmotion dysregulation (ED) is a key target for change among empirically supported treatments for emotional disorders, including dialectical behaviour therapy skills training (DBT‐ST), yet how treatments improve ED is poorly understood. Using data from a randomised trial of DBT‐ST versus supportive group therapy for transdiagnostic ED, we tested whether three mechanistic variables—behavioural skills use, mindfulness, and perceived control—explain variability in ED within people over time. We additionally explored the mediating roles of these variables between conditions. Adults with transdiagnostic ED (N = 44) participated in weekly groups for 4 months, with assessments at pre‐, mid‐ and post‐treatment and at 2‐month follow‐up. As hypothesised, multilevel models disaggregating within‐ and between‐person effects indicated that skills use, mindfulness, and perceived control each had significant total and unique within‐person associations with ED at concurrent time points, net the effect of time. Unexpectedly, these within‐person relations were not significant for mechanistic variables predicting ED 2 months later. Further, unique between‐person variability in skills use, mindfulness, and perceived control did not significantly mediate the relationship between condition and ED improvements. The present study is an important step in clarifying ED mechanisms of change, both within and between persons.
An integrative view on the systematic position of the cupressophyteCephalotaxus
Authors: Yang Yong , Yang Zhi , Ferguson David Kay , Shong Jia‐Yi 
Published: July 2023

AbstractWe made an in‐depth review of historical studies of the cupressophyte conifer genusCephalotaxusSiebold & Zucc. with an emphasis on its systematic position. We suggest that the systematic position of the genus is better understood using an integrative approach, so the evolution of phenetic characters is discussed within the context of recent phylogenomics. We propose that the genus should be classified as a separate family Cephalotaxaceae belonging to the clade consisting of Cupressaceae, Cephalotaxaceae, and Taxaceae; the family Cephalotaxaceae is sister to the Taxaceae but not nested within the Taxaceae and is characterized by a unique set of characters including morphology, anatomy, embryology, and chemistry. The family Cephalotaxaceae shows transitional characters between the Cupressaceae and the Taxaceae; the family possesses female cones with a primary cone axis bearing 5–8 pairs of decussate bracts, which is similar to the typical female cones of the Cupressaceae, on the one hand, and may have given rise to the reduced female cone of the Taxaceae with one terminal ovule partially or completely enclosed in a fleshy aril. In parallel, the compound male cone of the Cephalotaxaceae evolved into the seemingly “simple” male cones of the Taxaceae by means of reduction, elimination, and fusion.
Diuretic dose is a strong prognostic factor in ambulatory patients awaiting heart transplantation
Authors: Baudry Guillaume , Coutance Guillaume , Dorent Richard , Bauer Fabrice , Blanchart Katrien , Boignard Aude , Chabanne Céline , Delmas Clément , D'Ostrevy Nicolas , Epailly Eric , Gariboldi Vlad , Gaudard Philippe , Goéminne Céline , Grosjean Sandrine , Guihaire Julien , Guillemain Romain , Mattei Mathieu , Nubret Karine , Pattier Sabine , Vermes Emmanuelle , Sebbag Laurent , Duarte Kevin , Girerd Nicolas 
Published: July 2023

AbstractAimsThe prognostic value of ‘high dose’ loop diuretics in advanced heart failure outpatients is unclear. We aimed to assess the prognosis associated with loop diuretic dose in ambulatory patients awaiting heart transplantation (HT).Methods and resultsAll ambulatory patients (n = 700, median age 55 years and 70% men) registered on the French national HT waiting list between 1 January 2013 and 31 December 2019 were included. Patients were divided into ‘low dose’, ‘intermediate dose’, and ‘high dose’ loop diuretics corresponding to furosemide equivalent doses of ≤40, 40–250, and >250 mg, respectively. The primary outcome was a combined criterion of waitlist death and urgent HT. N‐terminal pro‐B‐type natriuretic peptide, creatinine levels, pulmonary capillary wedge pressure, and pulmonary pressures gradually increased with higher diuretic dose. At 12 months, the risk of waitlist death/urgent HT was 7.4%, 19.2%, and 25.6% (P = 0.001) for ‘low dose’, ‘intermediate dose’, and ‘high dose’ patients, respectively. When adjusting for confounders, including natriuretic peptides, hepatic, and renal function, the ‘high dose’ group was associated with increased waitlist mortality or urgent HT [adjusted hazard ratio (HR) 2.23, 1.33 to 3.73; P = 0.002] and a six‐fold higher risk of waitlist death (adjusted HR 6.18, 2.16 to 17.72; P < 0.001) when compared with the ‘low dose’ group. ‘Intermediate doses’ were not significantly associated with these two outcomes in adjusted models (P > 0.05).ConclusionsA ‘high dose’ of loop diuretics is strongly associated with residual congestion and is a predictor of outcome in patients awaiting HT despite adjustment for classical cardiorenal risk factors. This routine variable may be helpful for risk stratification of pre‐HT patients.
Electrochemical Reduction of 1H‐Thioxanthene‐1,4,9‐trione and 3‐Methyl‐1H‐thioxanthene‐1,4,9‐trione – Representatives of a New Class of Heterocycles Related to Thioxanthenone
Authors: Odintsov Danila S. , Os'kina Irina A. , Irtegova Irina G. , Shundrin Leonid A. 
Published: July 2023

AbstractA convenient synthetic route was proposed for the synthesis of 3‐methyl‐1H‐thioxanthene‐1,4,9‐trione. This compound and its 3‐H congener are representatives of a new class of thioxanthone‐like heterocycles, which can be used as building blocks for materials used in organic electronics. Electrochemical reduction (ECR) of 1H‐thioxanthene‐1,4,9‐trione and its 3‐methyl derivative in DMF and acetonitrile is a three‐stage process leading to the formation of the corresponding long‐lived radical anions and unstable dianions at the first and second stages, respectively. In a protolytic equilibrium, dianions are converted into 1‐oxy‐4‐hydroxy‐1H‐thioxanthene‐9‐one anions. Their one‐electron reversible ECR leads to the corresponding radical dianions, followed by the formation of (3‐methyl/H)‐1,4‐dihydroxy‐1H‐thioxantene‐9‐ones as the final products. The latter compounds can be converted into the initial (3‐methyl/H)‐1H‐thioxanthene‐1,4,9‐triones. The main intermediates were characterized using a combination of cyclic voltammetry, EPR spectroscopy, 3D spectroelectrochemistry, and DFT calculations at the (U)B3LYP/6‐31+G*/PCM level of theory. A general ECR scheme was proposed for both types of compounds.
LPB‐SPP: Solving the internet of things service placement problem using the learner performance‐based behavior algorithm
Authors: Hu Chunfen , Zhou Haifei , Lv Shiyun , Krishna Saraswat Shelesh 
Published: July 2023

AbstractNowadays, fog computing has joined cloud computing as an emerging computing paradigm to provide resources at the network edge. Fog servers process data associated with Internet of Things (IoT) devices independently of cloud computing, thus saving bandwidth, resource reservations, and storage for real‐time applications with lower latency. Besides, cloud computing supports the integration of edge and cloud resources and facilitates the placement of IoT applications at the network edge. Recent researchers focus on how to deploy IoT services as components of IoT applications on fog computing units, where the loss of resources, energy, and bandwidth are minimized. This problem, known as the IoT service placement problem (SPP), is NP‐hard, and meta‐heuristic models are popular to address it. Each IoT service has its own requirements in terms of latency sensitivity, processor, memory, and storage. Meanwhile, fog computing units are heterogeneous and have limited resource capacities. Therefore, SPP should be addressed by considering the features of fog environment, tolerable delay, and network bandwidth. We formulate SPP as a multi‐objective optimization problem with the perspective of throughput, service cost, resource utilization, energy consumption, and service latency. To solve this problem, the learner performance‐based behavior (LPB) algorithm is presented as a meta‐heuristic model that originates from the MAPE‐K autonomous planning model. The proposed approach, LPB‐SPP, considers resource consumption distribution and service deployment prioritization, and also uses the concepts of elitism and balanced resource consumption to improve the placement process. The validation of LPB‐SPP has been done using different performance metrics and the results have been compared against state‐of‐the‐art algorithms. Simulations show that LPB‐SPP performs better in most comparisons.
High Thermoelectric Performance in Ti3C2Tx MXene/Sb2Te3 Composite Film for Highly Flexible Thermoelectric Devices
Authors: Xu Yunhe , Wu Bo , Hou Chengyi , Li Yaogang , Wang Hongzhi , Zhang Qinghong 
Published: July 2023

AbstractFlexible thin‐film thermoelectric devices (TEDs) can generate electricity from the heat emitted by the human body, which holds great promise for use in energy supply and biomonitoring technologies. The p‐type Sb2Te3 hexagon nanosheets are prepared by the hydrothermal synthesis method and compounded with Ti3C2Tx to make composite films, and the results show that the Ti3C2Tx content has a significant impact on the thermoelectric properties of the composite films. When the Ti3C2Tx content is 2 wt%, the power factor of the composite film reaches ≈59 µW m−1 K−2. Due to the outstanding electrical conductivity, high specific surface area, and excellent flexibility of Ti3C2Tx, the composite films also exhibit excellent thermoelectric and mechanical properties. Moreover, the small addition of Ti3C2Tx has a negligible effect on the phase composition of Sb2Te3 films. The TED consists of seven legs with an output voltage of 45 mV at ΔT = 30 K. The potential of highly flexible thin film TEDs for wearable energy collecting and sensing is great.
An efficient graph‐based peer selection method for financial statements
Authors: Noels Sander , De Ridder Simon , Viaene Sébastien , De Bie Tijl 
Published: July 2023

SummaryComparing companies can be useful for various purposes. Despite the widespread use of industry classification systems as a peer selection standard, these have been criticized for various reasons. Financial statements, however, offer a promising alternative to such classification systems. They are standardized, widely available, and offer deep insights into the nature of the company. In this paper, we present a graph distance metric for financial statements using the earth mover's distance. When using the distance metric on real‐world tasks such as peer identification and industry classification, it shows promising results in terms of accuracy and computational efficiency.
Metformin prevents osteoblast‐like potential and calcification in lung cancer A549 cells
Authors: Yadav Pooja , Makwana Sweta , Bansal Shivani , Soni Sneha , Mahapatra Manas K. , Bandyopadhayaya Shreetama , Tailor Rashmi , Shrivastava Sandeep K. , Sharma Lokendra K. , Mandal Chandi C. 
Published: July 2023

AbstractIn spite of recent advances made in understanding its progression, cancer is still a leading cause of death across the nations. Molecular pathophysiology of these cancer cells largely differs depending on cancer types and even within the same tumor. Pathological mineralization/calcification is seen in various tissues including breast, prostate, and lung cancer. Osteoblast‐like cells derived after trans‐differentiation of mesenchymal cells usually drive calcium deposition in various tissues. This study aims to explore the presence of osteoblast‐like potential in lung cancer cells and its prevention. ALP assay, ALP staining, nodule formation, RT‐PCR, RT‐qPCR, and western blot analysis experiments were carried out in lung cancer A549 cells to achieve said objective. Expressions of various osteoblast markers (e.g., ALP, OPN, RUNX2, and Osterix) along with osteoinducer genes (BMP‐2 and BMP‐4) were observed in A549 cells. Moreover, ALP activity and ability leading to nodule formation revealed the presence of osteoblast‐like potential in lung cancer cells. Here, BMP‐2 treatment increased expressions of osteoblast transcription factors such as RUNX2 and Osterix, enhanced ALP activity, and augmented calcification in this cell line. It was also observed that antidiabetic metformin inhibited BMP‐2 mediated increase in osteoblast‐like potential and calcification in these cancer cells. The current study noted that metformin blocked BMP‐2 mediated increase in epithelial to mesenchymal transition (EMT) in A549 cells. The above findings for the first time unravel that A549 cells possess osteoblast‐like potential which drives lung cancer calcification. Metformin might prevent BMP‐2 induced osteoblast‐like phenotype of the lung cancer cells with concomitant inhibition of EMT to inhibit lung cancer tissue calcification.
An insight into PI3k/Akt pathway and associated protein–protein interactions in metabolic syndrome: A recent update
Authors: Verma Kanika , Jaiswal Ritika , Paliwal Sarvesh , Dwivedi Jaya , Sharma Swapnil 
Published: July 2023

AbstractAkt, a known serine/threonine‐protein kinase B has been revealed to be an imperative protein of the PI3K/Akt pathway. Akt is available in three isoforms, Akt1, Akt2, and Akt3. Ubiquitously expressed Akt1 & Akt2 are essential for cell survival and are believed to be involved in regulating glucose homeostasis. PI3K/Akt pathway has been evidenced to be associated with metabolic diseases viz. hypertension, dyslipidemia, and diabetes. Akt interacting proteins have been revealed to be scaffold proteins of the PI3K/Akt pathway. Notably, some protein–protein interactions are imperative for the inhibition or uncontrolled activation of these signaling pathways. For instance, Akt interacting protein binds with other protein namely, FOXO1 and mTOR, and play a key role in the onset and progression of metabolic syndrome (MS). The purpose of this review is to highlight the role of the PI3K/Akt pathway and associated protein–protein interactions which might serve as a valuable tool for investigators to develop some new promising therapeutic agents in the management of MS.
Provider perspectives on patient‐centredness: participatory formative research and rapid analysis methods to inform the design and implementation of a facility‐based HIV care improvement intervention in Zambia
Authors: Mwamba Chanda , Beres Laura K. , Mukamba Njekwa , Jere Lazarus , Foloko Marksman , Lumbo Kasapo , Sikombe Kombatende , Simbeza Sandra , Mody Aaloke , Pry Jake M. , Holmes Charles B. , Sikazwe Izukanji , Moore Carolyn Bolton , Christopoulos Katerina , Sharma Anjali , Geng Elvin H. 
Published: July 2023

AbstractIntroductionImplementation of patient‐centred care (PCC) practices in HIV treatment depends on healthcare workers’ (HCWs) perceptions of the acceptability, appropriateness and feasibility of such practices (e.g. use of intentional, metric‐driven activities to improve patient experiences).MethodsWe applied rapid, rigorous formative research methods to refine a PCC intervention for future trial. In 2018, we conducted focus group discussions (FGDs) with 46 HCWs purposefully selected from two pilot sites. We elicited HCW perceptions of HIV service delivery, HCW motivation and perceived value of patient experience measures intended to improve PCC. FGDs utilized participatory methods to understand HCW responses to patient‐reported care engagement challenges and Scholl's PCC Framework principles (e.g. seeing a patient as a unique person), enablers (e.g. care coordination) and activities (e.g. patient involvement). Our rapid analysis used analytic memos, thematic analysis, research team debriefs and HCW feedback to inform time‐sensitive trial implementation.ResultsWhile HCWs nearly universally identified with and supported principles of PCC in both facilities, they raised practical barriers given the practice environment. HCWs described motivation to help patients, attached value to seeing positive health outcomes and the importance of teamwork. However, HCWs reported challenges with enablers needed to deliver PCC. HCWs cited a work culture characterized by differential power dynamics between cadres and departments restricting HCW autonomy and resource access. Barriers included inflexibility in accommodating individual patient needs due to high patient volumes, limited human resources, laboratory capacity, infrastructure and skills translating patient perspectives into practice. HCW motivation was negatively influenced by encounters with “difficult patients,” and feeling “unappreciated” by management, resulting in cognitive dissonance between HCW beliefs and behaviours. However, the enactment of PCC values also occurred. Results suggested that PCC interventions should reduce practice barriers, highlighting the value of mentors who could help HCWs dynamically engage with health system constraints, to facilitate PCC.ConclusionsWhile HCWs perceived PCC principles as acceptable, they did not think it universally appropriate or feasible given the practice environment. Participatory and rapid methods provided timely insight that PCC interventions must provide clear and effective systems enabling PCC activities by measuring and mitigating relational and organizational constraints amenable to change such as inter‐cadre coordination.