bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doctors and Pain Patients Avoid “Ruan” in the Supreme Court
Authors: Rothstein Mark A. , Dyche Mary E. , Irzyk Julia 
Published: March 2023

AbstractPhysicians’ fear of criminal prosecution for prescribing opioid analgesics is a major reason why many chronic pain patients are having an increasingly difficult time obtaining medically appropriate pain relief. In Ruan v. United States, 142 S. Ct. 2370 (2022), the Supreme Court unanimously vacated two federal convictions under the Controlled Substances Act. The Court held that the government must prove that the defendant knowingly or intentionally acted in an unauthorized manner.
The $5 Billion Hop: Glatiramer Acetate and the US Patent System
Authors: Patel Neeraj G. , Kesselheim Aaron S. 
Published: March 2023

AbstractNew research and a government investigation have shed light on an anticompetitive practice called “Product Hopping” and specifically how it was employed in the case of the multiple sclerosis treatment glatiramer acetate beginning in 2014, which cost payers billions of dollars. We examine this case as well as a separate, impending instance of product hopping.
The Right to Repair Software-Dependent Medical Devices
Authors: Lindgren Lars , Kesselheim Aaron S. , Kramer Daniel B. 
Published: March 2023

AbstractThe “right to repair” movement highlights opportunities to reduce health care costs and promote public health resilience through increased competition in the way in which medical devices are serviced and updated over their lifespan. We review legislative and legal facets of third-party repair of medical devices, and conclude with specific recommendations to help this market function more efficiently to the benefit of patients and health care systems.
Challenges and Prospects for the Intergovernmental Negotiations to Develop a New Instrument on Pandemic Prevention, Preparedness, and Response
Authors: Solomon Steven 
Published: March 2023

AbstractAs Member States of the World Health Organization (WHO) meet in an International Negotiating Body (INB) to negotiate a legally binding agreement on pandemic prevention, preparedness, and response for submission to the 77th World Health Assembly in May 2024, this column reflects on creative but pragmatic and complementary means that could be employed in the short timeframe allotted for this important global health law negotiation.
Respect for Communities in Health Justice
Authors: Galarneau Charlene , Smith Patrick T. 
Published: March 2023

AbstractHealth justice seeks, both conceptually and in practice, to strengthen community engagement and empowerment as an integral means of addressing health disparities. In this essay, we explore the nature of communities and their roles in health care/public health. We propose that an ethical principle of respect for communities is a requisite part of health justice. It is this respect for communities that ethically grounds health justice’s calls for greater community engagement and empowerment. Conceptions of health justice, we claim, will gain ethical power and coherence as this principle is more clearly recognized and further developed.
Health Justice and Just Transition
Authors: Pamukcu Aysha , Harris Angela P. 
Published: March 2023

AbstractJust Transition, an organizing and policy framework that has emerged from the climate justice movement, is a powerful upstream response to health disparities created by structural subordination. As the public health field pushes itself to address the “cause of causes” of unjust health disparities, Just Transition offers new possibilities for partnership and collective action. We introduce the Just Transition framework, explain its relevance to the concerns of health justice advocates, and provide some examples of how the two movements might work together.
The Anti-Transgender Medical Expert Industry
Authors: Caraballo Alejandra 
Published: March 2023

AbstractCivil rights attorneys challenging laws restricting transgender rights and access to healthcare often encounter anti-transgender medical experts in litigation at various stages. The experts often maintain dubious credentials in the relevant area of medical or scientific expertise which presents a challenge that undermines equitable access to justice by introducing pseudo-science into court proceedings. This commentary will discuss the phenomenon and propose a normative path forward.
Effects of developmental state on low-temperature physiology of the alfalfa leafcutting bee, Megachile rotundata
Authors: Bennett Meghan M. , DeBardlabon Korie M. , Rinehart Joseph P. , Yocum George D. , Greenlee Kendra J. 
Published: March 2023

AbstractThe success of agriculture relies on healthy bees to pollinate crops. Commercially managed pollinators are often kept under temperature-controlled conditions to better control development and optimize field performance. One such pollinator, the alfalfa leafcutting bee, Megachile rotundata, is the most widely used solitary bee in agriculture. Problematically, very little is known about the thermal physiology of M. rotundata or the consequences of artificial thermal regimes used in commercial management practices. Therefore, we took a broad look at the thermal performance of M. rotundata across development and the effects of commonly used commercial thermal regimes on adult bee physiology. After the termination of diapause, we hypothesized thermal sensitivity would vary across pupal metamorphosis. Our data show that bees in the post-diapause quiescent stage were more tolerant of low temperatures compared to bees in active development. We found that commercial practices applied during development decrease the likelihood of a bee recovering from another bout of thermal stress in adulthood, thereby decreasing their resilience. Lastly, commercial regimes applied during development affected the number of days to adult emergence, but the time of day that adults emerged was unaffected. Our data demonstrate the complex interactions between bee development and thermal regimes used in management. This knowledge can help improve the commercial management of these bees by optimizing the thermal regimes used and the timing of their application to alleviate negative downstream effects on adult performance.
Natural history of the parasite Waddycephalus in the Townsville region of north-east Australia
Authors: Midtun Halvard Aas , Higgie Megan , Hoskin Conrad 
Published: March 2023

AbstractWaddycephalus is an understudied genus of pentastomids native to Australia and south-east Asia. The genus was recognized in 1922 but there has been little research on these pentastomid tongue worms over the last century. A few observations suggest a complex life cycle through 3 trophic levels. We aimed to add knowledge to the Waddycephalus life cycle in woodland habitats in the Townsville region of north-east Australia. We used camera trapping to identify the most likely first-intermediate hosts (coprophagous insects), we conducted gecko surveys to identify multiple new gecko intermediate host species and we dissected road-killed snakes to identify additional definitive hosts. Our study paves the way for further research into the intriguing life cycle of Waddycephalus, investigation of spatial variation in prevalence and impacts of the parasite on host species.
The Effect of Social Pension on Material Hardship among Older Adults in Korea: Regression Discontinuity Estimation
Authors: Ahn Seoyeon , Kang Ji Young , Chun Yung , Park Sojung 
Published: March 2023

Abstract
The goal of this study was to examine the effect of a social pension programme for older adults in South Korea, Basic Pension Scheme (BPS) on material hardship and subjective well-being. We apply a regression discontinuity design (RDD) to estimate the effect of the BPS on the material hardship and life satisfaction of older people between the ages of sixty-one and sixty-eight. Data come from Korea Welfare Panel Study (KOWEPS) wave 12 survey (2017, N = 3,932). The BPS benefit reduces the risks of housing hardship, bill payment delay and food insecurity. Interestingly, while the effect sizes of the BPS on mitigating the material hardship increase as income decreases, the lower-income groups were less satisfied with the pension provision than middle- and upper-income groups. This study contributes to the growing body of literature on material hardship for older adults in an Asian country facing persistent old-age poverty and immature public pensions.
Political Centralization, Federalism, and Urbanization: Evidence from Australia
Authors: Wilkinson George , Haslam McKenzie Fiona , Bolleter Julian , Hooper Paula 
Published: March 2023

AbstractThe dominance of capital cities (urban primacy) is an enduring characteristic of Australian states. There has been limited empirical research examining the drivers of primacy in states despite some being extreme examples of the phenomenon, both in magnitude and scale. In light of institutional theories of settlement patterns, we developed a profile of Australian urbanization using a century of time-series data, descriptive statistics, and an empirical model of city populations. In Australian states high measures of primacy have endured with little evidence of disruption despite the enormous size of these states, their wealth, and population growth – factors associated with declining and low primacy. Statistically, state capital city status has a significant effect on city population size variation, with results suggesting primacy in states is in part a product of Australian federalism. This contrasts with views that suggest Australia’s scarcity of large non-capital cities is due to isolation, low population, and environmental determinism. The findings in this paper have major implications relative to national and/or state strategies that aim to decentralize population away from the primate cities.
COVID‐19 Pandemic Reveals Distinct Impact of Aerosols on Surface Solar Radiation in China
Authors: Yang Xin , Li Zhigang , Yao Zhanyu , Tang Hong , Yang Shili , Chen Lu 
Published: March 2023

AbstractWith the abrupt and significant drop of PM2.5 concentrations during the lockdown in 2020, hourly direct radiation (Rdir) at surface substantially increased in East China, such as Zhengzhou, Wuhan and Baoshan, with the maximum enhancement of 86% at Wuhan. Most of these stations had decreased diffuse radiation (Rdif) except Zhengzhou. Zhengzhou had both enhanced Rdir and Rdif, as well as reduced but still high PM2.5 concentrations, indicating atmospheric particles were more scattering in this region. At Beijing and Harbin in North and Northeast China, intensification of aerosol pollution led to hourly Rdir (Rdif) falling (rising) up to −28% (59%) and −23% (40%), respectively. By contrast, surface solar radiation (SSR) in West China was also greatly influenced by the elevated dust/smoke layers, revealed by aerosol layer vertical distribution and the reduction of SSR and PM2.5 concentrations. This study highlighted the importance of aerosol optical properties and vertical structures in aerosol–radiation interactions.
Global Asymmetries in the Influence of ENSO on Flood Risk Based on 1,600 Years of Hybrid Simulations
Authors: Del Rio Amador L. , Boudreault M. , Carozza D. A. 
Published: March 2023

AbstractEl Niño‐Southern Oscillation (ENSO) is often considered as a source of long‐term predictability for extreme events via its teleconnection patterns. However, given that its characteristic cycle varies from two to 7 years, it is difficult to obtain statistically significant conclusions based on observational periods spanning only a few decades. To overcome this, we apply the global flood risk modeling framework developed by Carozza and Boudreault to an equivalent of 1,600 years of bias‐corrected General Circulation Model outputs. The results show substantial anomalies in flood occurrences and impacts for El Niño and La Niña when compared to the all‐year baseline. We were able to obtain a larger global coverage of statistically significant results than previous studies limited to observational data. Asymmetries in anomalies for both ENSO phases show a larger global influence of El Niño than La Niña on flood hazard and risk.
Heterogeneity Versus Anisotropy and the State of Stress in Stable Cratons: Observations From a Deep Borehole in Northeastern Alberta, Canada
Authors: Wang Wenjing , Schmitt Douglas R. , Chan Judith 
Published: March 2023

AbstractGeophysical logs collected from a deep borehole drilled into the North American Craton in Northeastern Alberta shed valuable light on the state of stress in stable cratons. Observed breakout (BO) azimuths rotate between three depth intervals, ranging from 100° at 1,650–2,000 m to 173° at 2,000–2,210 m, and finally to 145° at the bottom. No apparent fractures that might have disturbed the stress field were found. Two potential causes of these rotating BOs can be either a heterogeneous stress field or elastic and strength anisotropy of the formation. The latter interpretation is favored since observed BO azimuths are strongly controlled by rock metamorphic textures, as validated by their close correlations with dip directions of foliation planes and polarization directions from dipole sonic logs. Monte Carlo realizations further demonstrate that anisotropic metamorphic rocks subjected to a uniform horizontal stress direction could result in the observed azimuth‐rotating BOs. Stress magnitudes inferred from this analysis, which incorporates rock anisotropy and weak foliation failure planes, suggest a normal faulting regime and a maximum horizontal compressive direction consistent with that in the overlying Western Canadian Sedimentary Basin (NE‐SW) and the motion of the North American plate. The inferred stress magnitudes are low and Mohr‐Coulomb analyses demonstrate that the formation is not near the critical condition for slip on weak planes. However, more detailed investigations should be conducted since Monte Carlo calculations indicate that analyses from BO widths, particularly when a conventional Kirsch‐based formula is employed, are highly nonunique, allowing for large variations in potential stress states.
Impact of Cyclonic Wind Anomalies Caused by Massive Winter Sea Ice Retreat in the Barents Sea on Atlantic Water Transport Toward the Arctic: A Model Study
Authors: Heukamp Finn Ole , Kanzow Torsten , Wang Qiang , Wekerle Claudia , Gerdes Rüdiger 
Published: March 2023

AbstractThe Arctic is warming much faster than the global average. This is known as Arctic Amplification and is caused by feedbacks in the local climate system. In this study, we explore a previously proposed hypothesis that an associated wind feedback in the Barents Sea could play an important role by increasing the warm water inflow into the Barents Sea. We find that the strong recent decrease in Barents Sea winter sea ice cover causes enhanced ocean‐atmosphere heat flux and a local air temperature increase, thus a reduction in sea level pressure and a local cyclonic wind anomaly with eastward winds in the Barents Sea Opening. By investigating various reanalysis products and performing high‐resolution perturbation experiments with the ocean and sea ice model FESOM2.1, we studied the impact of cyclonic atmospheric circulation changes on the warm Atlantic Water import into the Arctic via the Barents Sea and Fram Strait. We found that the observed wind changes do not significantly affect the warm water transport into the Barents Sea, which rejects the wind‐feedback hypothesis. At the same time, the cyclonic wind anomalies in the Barents Sea increase the amount of Atlantic Water recirculating westwards in Fram Strait by a downslope shift of the West Spitsbergen Current, and thus reduce Atlantic Water reaching the Arctic basin via Fram Strait. The resulting warm‐water anomaly in the Greenland Sea Gyre drives a local anticyclonic circulation anomaly.
Interaction between maternal immune activation and peripubertal stress in rats: impact on cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome
Authors: Capellán Roberto , Orihuel Javier , Marcos Alberto , Ucha Marcos , Moreno-Fernández Mario , Casquero-Veiga Marta , Soto-Montenegro María Luisa , Desco Manuel , Oteo-Vives Marta , Ibáñez-Moragues Marta , Magro-Calvo Natalia , Morcillo Miguel Ángel , Ambrosio Emilio , Higuera-Matas Alejandro 
Published: March 2023

AbstractSubstance use disorders are more prevalent in schizophrenia, but the causal links between both conditions remain unclear. Maternal immune activation (MIA) is associated with schizophrenia which may be triggered by stressful experiences during adolescence. Therefore, we used a double-hit rat model, combining MIA and peripubertal stress (PUS), to study cocaine addiction and the underlying neurobehavioural alterations. We injected lipopolysaccharide or saline on gestational days 15 and 16 to Sprague-Dawley dams. Their male offspring underwent five episodes of unpredictable stress every other day from postnatal day 28 to 38. When animals reached adulthood, we studied cocaine addiction-like behaviour, impulsivity, Pavlovian and instrumental conditioning, and several aspects of brain structure and function by MRI, PET and RNAseq. MIA facilitated the acquisition of cocaine self-administration and increased the motivation for the drug; however, PUS reduced cocaine intake, an effect that was reversed in MIA + PUS rats. We found concomitant brain alterations: MIA + PUS altered the structure and function of the dorsal striatum, increasing its volume and interfering with glutamatergic dynamics (PUS decreased the levels of NAA + NAAG but only in LPS animals) and modulated specific genes that could account for the restoration of cocaine intake such as the pentraxin family. On its own, PUS reduced hippocampal volume and hyperactivated the dorsal subiculum, also having a profound effect on the dorsal striatal transcriptome. However, these effects were obliterated when PUS occurred in animals with MIA experience. Our results describe an unprecedented interplay between MIA and stress on neurodevelopment and the susceptibility to cocaine addiction.
Qingre Xingyu recipe exerts inhibiting effects on ulcerative colitis development by inhibiting TNFα/NLRP3/Caspase-1/IL-1β pathway and macrophage M1 polarization
Authors: Ning Liqin , Ye Ningyuan , Ye Bai , Miao Zhiwei , Cao Tingting , Lu Weimin , Xu Danhua , Tan Chang , Xu Yi , Yan Jing 
Published: March 2023

AbstractAs a chronic inflammatory bowel disease, ulcerative colitis (UC) imposes a significant burden on public healthcare worldwide due to its increasing morbidity. Chinese medicines are regarded as potent therapeutic agents for UC treatment with minimal side effects. In the present study, we sought to determine the novel role of a traditional medicine Qingre Xingyu (QRXY) recipe in the development of UC and aimed to contribute to the currently available knowledge about UC by exploring the downstream mechanism of QRXY recipe in UC. Mouse models of UC were established by injections with dextran sulphate sodium (DSS), where the expression of tumor necrosis factor-alpha (TNFα), NLR family pyrin domain containing 3 (NLRP3), and interleukin-1β (IL-1β) was determined followed by an analysis of their interactions. The DSS-treated NLRP3 knockout (−/−) Caco-2 cell model was successfully constructed. The in vitro and in vivo effects of the QRXY recipe on UC were investigated with the determination of disease activity index (DAI), histopathological scores, transepithelial electrical resistance, FITC-dextran, as well as cell proliferation and apoptosis. In vivo and in vitro experiments indicated that the QRXY recipe reduced the degree of intestinal mucosal injury of UC mice and functional damage of DSS-induced Caco-2 cells by inhibition of the TNFα/NLRP3/caspase-1/IL-1β pathway and M1 polarization of macrophages, and TNFα overexpression or NLRP3 knockdown could counterweigh the therapeutic effects of QRXY recipe. To conclude, our study elicited that QRXY inhibited the expression of TNFα and inactivated the NLRP3/Caspase-1/IL-1β pathway, thereby alleviating intestinal mucosal injury and relieving UC in mice.
Diode effect in Josephson junctions with a single magnetic atom
Authors: Trahms Martina , Melischek Larissa , Steiner Jacob F. , Mahendru Bharti , Tamir Idan , Bogdanoff Nils , Peters Olof , Reecht Gaël , Winkelmann Clemens B. , von Oppen Felix , Franke Katharina J. 
Published: March 2023

AbstractCurrent flow in electronic devices can be asymmetric with bias direction, a phenomenon underlying the utility of diodes1 and known as non-reciprocal charge transport2. The promise of dissipationless electronics has recently stimulated the quest for superconducting diodes, and non-reciprocal superconducting devices have been realized in various non-centrosymmetric systems3–10. Here we investigate the ultimate limits of miniaturization by creating atomic-scale Pb–Pb Josephson junctions in a scanning tunnelling microscope. Pristine junctions stabilized by a single Pb atom exhibit hysteretic behaviour, confirming the high quality of the junctions, but no asymmetry between the bias directions. Non-reciprocal supercurrents emerge when inserting a single magnetic atom into the junction, with the preferred direction depending on the atomic species. Aided by theoretical modelling, we trace the non-reciprocity to quasiparticle currents flowing by means of electron–hole asymmetric Yu–Shiba–Rusinov states inside the superconducting energy gap and identify a new mechanism for diode behaviour in Josephson junctions. Our results open new avenues for creating atomic-scale Josephson diodes and tuning their properties through single-atom manipulation.
Fumarate induces vesicular release of mtDNA to drive innate immunity
Authors: Zecchini Vincent , Paupe Vincent , Herranz-Montoya Irene , Janssen Joëlle , Wortel Inge M. N. , Morris Jordan L. , Ferguson Ashley , Chowdury Suvagata Roy , Segarra-Mondejar Marc , Costa Ana S. H. , Pereira Gonçalo C. , Tronci Laura , Young Timothy , Nikitopoulou Efterpi , Yang Ming , Bihary Dóra , Caicci Federico , Nagashima Shun , Speed Alyson , Bokea Kalliopi , Baig Zara , Samarajiwa Shamith , Tran Maxine , Mitchell Thomas , Johnson Mark , Prudent Julien , Frezza Christian 
Published: March 2023

AbstractMutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma1. Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate2. However, although the long-term consequences of FH loss have been described, the acute response has not so far been investigated. Here we generated an inducible mouse model to study the chronology of FH loss in the kidney. We show that loss of FH leads to early alterations of mitochondrial morphology and the release of mitochondrial DNA (mtDNA) into the cytosol, where it triggers the activation of the cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING)–TANK-binding kinase 1 (TBK1) pathway and stimulates an inflammatory response that is also partially dependent on retinoic-acid-inducible gene I (RIG-I). Mechanistically, we show that this phenotype is mediated by fumarate and occurs selectively through mitochondrial-derived vesicles in a manner that depends on sorting nexin 9 (SNX9). These results reveal that increased levels of intracellular fumarate induce a remodelling of the mitochondrial network and the generation of mitochondrial-derived vesicles, which allows the release of mtDNAin the cytosol and subsequent activation of the innate immune response.