bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Diabetic Retinopathy Severity With High Ambulatory Blood Pressure and Suppressed Serum Renin Levels
Authors: Sada Kentaro , Yoshida Yuichi , Shibuta Kanako , Kimoto Kenichi , Miyamoto Shotaro , Ozeki Yoshinori , Okamoto Mitsuhiro , Gotoh Koro , Masaki Takayuki , Yokoyama Katsuhiko , Kubota Toshiaki , Shibata Hirotaka 
Published: June 2023

Abstract

Context
The relationships between serum renin levels, severity of diabetic retinopathy (DR), and 24-hour blood pressure (BP) have not been previously reported.

Objective
To explore causes for DR and the relationships of 24-hour ambulatory BP, and hormone levels with the severity of DR.

Methods
The diabetic patients were classified as having no DR, simple DR, or severe DR (preproliferative DR plus proliferative DR) based on funduscopic examination, and we measured 24-hour BP, serum active renin (ARC), aldosterone (SAC), adrenocorticotropic hormone, and cortisol levels in each group.

Results
Compared to those with no DR or simple DR, patients with severe DR showed significantly higher 24-hour BPs, including daytime and nighttime systolic and diastolic BP levels, independent of diabetic duration and HbA1c levels. The variability of nighttime systolic BP was greater in patients with severe DR than in those with nonsevere DR, although nocturnal BP reduction was similar between the groups. The ambulatory BPs were significantly inversely associated with ARC. The ARC was significantly lower in severe DR patients than in those with no DR or simple DR (3.2 [1.5-13.6] vs 9.8 [4.6-18.0] pg/mL, P &lt; .05), but there were no differences in SAC in patients taking calcium channel blockers and/or α-blockers. No associations were found between DR severity and other hormone levels.

Conclusion
Severe DR was associated with higher 24-hour BPs and suppressed ARC. These findings suggest that mineralocorticoid receptor overactivation may play a role in higher BP levels and severe DR in diabetic patients.
The Glucose Challenge Test in Pregnancy Identifies Future Risk of Diabetes
Authors: Retnakaran Ravi , Shah Baiju R 
Published: June 2023

Abstract

Context
Women with gestational diabetes (GDM) have an increased future risk of type 2 diabetes but, in practice, their recommended postpartum glucose tolerance testing is often missed or substituted with measurement of A1c instead.

Objective
We hypothesized that the antenatal screening glucose challenge test (GCT) should predict future diabetes risk and, if so, would have thresholds that identify the same degree of risk as the diagnosis of prediabetes on postpartum measurement of A1c.

Methods
With population-based administrative databases, we identified all women in Ontario, Canada, who had a GCT in pregnancy with delivery between January 2007 and December 2017, followed by measurement of A1c and fasting glucose within 2 years postpartum (n = 141 858, including 19 034 with GDM). Women were followed over a median of 3.5 years for the development of diabetes.

Results
Under the assumption of a linear exposure effect, the 1-hour post-challenge glucose concentration on the GCT was associated with an increased likelihood of developing diabetes (hazard ratio 1.39; 95% CI, 1.38-1.40). A GCT threshold of 8.0 mmol/L predicted the same 5-year risk of diabetes (6.0%; 95% CI, 5.8-6.2) as postpartum A1c 5.7% (identifying prediabetes). Moreover, in women with GDM, a GCT threshold of 9.8 mmol/L equaled prediabetes on postpartum A1c in predicting a 5-year risk of diabetes of 16.5% (14.8-18.2).

Conclusion
The GCT offers predictive capacity for future diabetes in pregnant women. In women with GDM, this insight could identify those at highest risk of diabetes, toward whom postpartum screening efforts should be most strongly directed.
Simplified Easy-Accessible Smartphone-Based Photogrammetry for 3-Dimensional Anatomy Presentation Exemplified With a Photorealistic Cadaver-Based Model of the Intracranial and Extracranial Course of the Facial Nerve
Authors: Krogager Markus E. , Fugleholm Kåre , Mathiesen Tiit I. , Spiriev Toma 
Published: June 2023

BACKGROUND AND OBJECTIVES:
Smartphone-based photogrammetry (SMPhP) was recently presented as a practical and simple algorithm to create photorealistic 3-dimensional (3D) models that benefit from volumetric presentation of real anatomic dissections. Subsequently, there is a need to adapt the techniques for realistic depiction of layered anatomic structures, such as the course of cranial nerves and deep intracranial structures; the feasibility must be tested empirically. This study sought to adapt and test the technique for visualization of the combined intracranial and extracranial course of the facial nerve's complex anatomy and analyze feasibility and limitations.

METHODS:
We dissected 1 latex-injected cadaver head to depict the facial nerve from the meatal to the extracranial portion. A smartphone camera alone was used to photograph the specimen, and dynamic lighting was applied to improve presentation of deep anatomic structures. Three-dimensional models were created with a cloud-based photogrammetry application.

RESULTS:
Four 3D models were generated. Two models showed the extracranial portions of the facial nerve before and after removal of the parotid gland; 1 model showed the facial nerve in the fallopian canal after mastoidectomy, and 1 model showed the intratemporal segments. Relevant anatomic structures were annotated through a web-viewer platform. The photographic quality of the 3D models provided sufficient resolution for imaging of the extracranial and mastoid portions of the facial nerve, whereas imaging of the meatal segment only lacked sufficient precision and resolution.

CONCLUSION:
A simple and accessible SMPhP algorithm allows 3D visualization of complex intracranial and extracranial neuroanatomy with sufficient detail to realistically depict superficial and deeper anatomic structures.
The insulator BEAF32 controls the spatial-temporal expression profile of the telomeric retrotransposon TART in the Drosophila germline
Authors: Sokolova Olesya , Morgunova Valeriya , Sizova Tatyana V. , Komarov Pavel A. , Olenkina Oxana M. , Babaev Dmitry S. , Mikhaleva Elena A. , Kwon Dmitry A. , Erokhin Maksim , Kalmykova Alla 
Published: June 2023

ABSTRACT
Insulators are architectural elements implicated in the organization of higher-order chromatin structures and transcriptional regulation. However, it is still unknown how insulators contribute to Drosophila telomere maintenance. Although the Drosophila telomeric retrotransposons HeT-A and TART occupy a common genomic niche, they are regulated independently. TART elements are believed to provide reverse transcriptase activity, whereas HeT-A transcripts serve as a template for telomere elongation. Here, we report that insulator complexes associate with TART and contribute to its transcriptional regulation in the Drosophila germline. Chromatin immunoprecipitation revealed that the insulator complex containing BEAF32, Chriz, and DREF proteins occupy the TART promoter. BEAF32 depletion causes derepression and chromatin changes at TART in ovaries. Moreover, an expansion of TART copy number was observed in the genome of the BEAF32 mutant strain. BEAF32 localizes between the TART enhancer and promoter, suggesting that it blocks enhancer–promoter interactions. Our study found that TART repression is released in the germ cysts as a result of the normal reduction of BEAF32 expression at this developmental stage. We suggest that coordinated expression of telomeric repeats during development underlies telomere elongation control.
Tailor-to-Target: Configuring Collaborative Shareholder Engagements on Climate Change
Authors: Slager Rieneke , Chuah Kevin , Gond Jean-Pascal , Furnari Santi , Homanen Mikael 
Published: June 2023

We study collaborative shareholder engagements on climate change issues. These engagements involve coalitions of investors pursuing behind-the-scenes dialogue to encourage target firms to adopt environmental sustainability practices. Drawing on a unique data set of 553 engagements coordinated by the United Nations–supported Principles for Responsible Investment—and an innovative mixed-methods approach integrating fuzzy-set qualitative comparative analysis with regression analysis and qualitative interviews—we investigate how four coalition composition levers (coalition size, shareholding stake, experience, local access) combine to enable or hinder engagement success. We find that successful coalitions use four configurations of coalition composition levers that are tailored to target firms’ financial capacity and environmental predispositions, that is, target firms’ receptivity. Unsuccessful configurations instead emphasize single levers at the expense of others. Drawing on qualitative interviews, we identify three mechanisms (synchronizing, contextualizing, overfocusing) that plausibly underly the identified configurations and provide investor coalitions with knowledge about target firms and their local contexts, thus enhancing communication and understanding between investor coalitions and target firms. Our study contributes an emerging “tailor-to-target” theory of collaborative shareholder engagement that extends the literature by showing the importance of designing investor coalitions for effective climate-related engagement and the value of conceiving coalitions as different configurations of the same levers that can fit a target firm’s receptivity. From a practical perspective, our study prompts investors to move beyond one-size-fits-all approaches to instead tailor their engagement strategies to target firms’ receptivity. This paper was accepted by Glen Dowell, Special Section of Management Science on Business and Climate Change. Funding: This work was supported by Principles for Responsible Investment (PRI Research Grant). Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4806 .
Characteristics of neurogenic lower urinary tract dysfunction patients at Cipto Mangunkusumo Hospital
Authors: Widia Fina , Indraswari Madhyra Tri , Rahardjo Harrina Erlianti 
Published: June 2023

BACKGROUND Neurogenic lower urinary tract dysfunction (NLUTD) is an abnormal function of the bladder, urethra (and/or prostate in males) in patients with a clinically confirmed relevant neurologic disorder. Hence, accurate diagnosis and management of NLUTD is crucial. This study aimed to recognize the characteristics of NLUTD to identify, manage, and prevent the associated complications.
METHODS This retrospective study was conducted at the Outpatient Clinic of the Department of Urology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from January 2011 to December 2021. The study analyzed data collected from voiding dysfunction patients with upper motor neurological disorders who underwent urodynamic studies during the study period. Incomplete data in the medical records were excluded.
RESULTS Mean age of the participants was 50.7 (18–95) years old. The most common cause of NLUTD was stroke (26.6%), followed by unspecified groups and spinal cord injury. Patients under 20 years old were affected by trauma and congenital defects. Of the patients, 34.0% had urinary retention, and 18.1% had incontinence. Small bladder capacity occurred in patients with stroke, Parkinson’s disease, and spinal/cerebral tumors, leading to decreased bladder compliance.
CONCLUSIONS NLUTD was associated with aging, with upper motor neurological lesions such as trauma, stroke, and spinal/cerebral injury being the most common etiologies. Most patients with NLUTD had small bladder capacity and decreased compliance based on urodynamic result.
Explaining disparities in cognitive functioning: a test of competing hypotheses
Authors: Liew Hui-Peng 
Published: June 2023

This study seeks to examine how the trajectories of total cognition scores exhibited by two birth cohorts vary by race/ethnicity, gender and the level of education. The empirical work of this study is be based on the 1998–2014 Health and Retirement Study (HRS) and the HRS Cross-Wave Tracker file. The analysis is limited to individuals with available information on cognitive functioning, sex, race/ethnicity, wave, highest level of education, and the physical comorbidities associated with cognitive functioning (20,985 from the Traditionalist cohort and 11,077 from the Baby Boomer cohort). Growth curve modelling is used to assess the aims of this study.
Findings reveal that the cumulative advantage (disadvantage), persistent inequality and age-as-leveller hypotheses explain heterogeneity in total cognition scores for different race/ethnicity–sex groups, race/ethnicity–education and education–sex groups. These findings suggest that the development of an integrated treatment and screening mechanisms for physical comorbidities and cognitive functioning, and for the design of preventive strategies with the purpose of slowing or avoiding cognitive decline and maintaining healthy cognitive function should have a particular focus on females, racial ethnic minorities and those with low education.
High-power two-color Kerr frequency comb generation on the gallium phosphide-on-insulator platform at SWIR and MIR spectra
Authors: Ji Houling , Geng Zhaoting , Cheng Weiren , Wu Pengzhuo , Yu Zhuoyu , Liu Yihan , Yu Xiaolun , Li Yi , Zhao Qiancheng 
Published: June 2023

Optical frequency combs (OFCs) covering multiple spectral windows are of great interest as broadband coherent light sources. Pushing into high powers for traditional single OFCs as well as nonlinear frequency translated OFCs led to the narrowing of their bandwidths. Here, we present a hybrid integrated solution on the gallium phosphide-on-insulator (GaP-OI) platform to generate high-power two-color Kerr frequency combs at both the short-wave infrared (SWIR) and the mid-infrared (MIR) spectra. The design consists of a GaP-OI resonator with a partially etched gap for frequency comb generation at the two colors and a modal phase-matched strip waveguide for a second-harmonic generation (SHG). The resonator has a 3.25 µm wide anomalous dispersion window, which is enabled by mode hybridization and higher-order modes waveguide dispersion. The pump light at 1550 nm wavelength is frequency doubled from the 3100 nm wavelength light source, with a normalized SHG conversion efficiency of 793%W−1cm−2. We also propose the ring-bus coupler design to efficiently deliver optical power into the resonator while suppressing the leakage out of the resonator. The simulated two-color combs show a bandwidth of 87 nm above the −30dBm power level at the SWIR spectrum and a bandwidth of 749 nm above the same power level at the MIR spectrum. Our proposed two-color OFC generation scheme levitates the ceiling in terms of high power and broad bandwidth simultaneously on a single platform, paving the way toward monolithic solutions to integrated broadband coherent sources.
Demographic, social, and behavioral correlates of SARS-CoV-2 seropositivity in a representative, population-based study of Minnesota residents
Authors: Abhold Jordan , Wozniak Abigail , Mulcahy John , Walsh Sara , Zepeda Evelyn , Demmer Ryan , Yendell Stephanie , Hedberg Craig , Ulrich Angela , Wurtz Rebecca , Beebe Timothy 
Published: June 2023

Background
Monitoring COVID-19 infection risk in the general population is a public health priority. Few studies have measured seropositivity using representative, probability samples. The present study measured seropositivity in a representative population of Minnesota residents prior to vaccines and assess the characteristics, behaviors, and beliefs of the population at the outset of the pandemic and their association with subsequent infection.

Methods
Participants in the Minnesota COVID-19 Antibody Study (MCAS) were recruited from residents of Minnesota who participated in the COVID-19 Household Impact Survey (CIS), a population-based survey that collected data on physical health, mental health, and economic security information between April 20 and June 8 of 2020. This was followed by collection of antibody test results between December 29, 2020 and February 26, 2021. Demographic, behavioral, and attitudinal exposures were assessed for association with the outcome of interest, SARS-CoV-2 seroprevalence, using univariate and multivariate logistic regression.

Results
Of the 907 potential participants from the CIS, 585 respondents then consented to participate in the antibody testing (64.4% consent rate). Of these, results from 537 test kits were included in the final analytic sample, and 51 participants (9.5%) were seropositive. The overall weighted seroprevalence was calculated to be 11.81% (95% CI, 7.30%-16.32%) at of the time of test collection. In adjusted multivariate logistic regression models, significant associations between seroprevalence and the following were observed; being from 23–64 and 65+ age groups were both associated with higher odds of COVID-19 seropositivity compared to the 18–22 age group (17.8 [1.2–260.1] and 24.7 [1.5–404.4] respectively). When compared to a less than $30k annual income reference group, all higher income groups had significantly lower odds of seropositivity. Reporting practicing a number of 10 (median reported value in sample) or more of 19 potential COVID-19 mitigation factors (e.g. handwashing and mask wearing) was associated with lower odds of seropositivity (0.4 [0.1–0.99]) Finally, the presence of at least one household member in the age range of 6 to 17 years old was associated with higher odds of seropositivity (8.3 [1.2–57.0]).

Conclusions
The adjusted odds ratio of SARS-CoV-2 seroprevalence was significantly positively associated with increasing age and having household member(s) in the 6–17 year age group, while increasing income levels and a mitigation score at or above the median were shown to be significantly protective factors.
Incidence and risk factors of postoperative acute myocardial injury in noncardiac patients: A systematic review and meta-analysis
Authors: Chang Yuan , Zhou Mengjiao , Huang Jing , Wang Yanqiong , Shao Jianlin 
Published: June 2023

Introduction
Postoperative myocardial injury after noncardiac surgery is common and is associated with short- and long-term morbidity and mortality. However, the incidence and risk factors for postoperative acute myocardial injury (POAMI) are currently unknown due to inconsistent definitions.

Methods
We systematically searched PubMed and Web of Science to identify studies that applied the change value of preoperative and postoperative cardiac troponins to define cardiac injury. We estimated the pooled incidence, risk factors, and 30-day and long-term mortality of POAMI in noncardiac patients. The study protocol was registered with PROSPERO, CRD42023401607.

Results
Ten cohorts containing 11,494 patients were included for analysis. The pooled incidence of POAMI was 20% (95% CI: 16% to 23%). Preoperative hypertension (OR: 1.47; 95% CI: 1.30 to 1.66), cardiac failure (OR: 2.63; 95% CI: 2.01 to 3.44), renal impairment (OR: 1.66; 95% CI: 1.48 to 1.86), diabetes (OR: 1.43; 95% CI: 1.27 to 1.61), and preoperative beta-blocker intake (OR: 1.65; 95% CI: 1.10 to 2.49) were the risk factors for POAMI. Age (mean difference: 2.08 years; 95% CI: -0.47 to 4.62), sex (male, OR: 1.16; 95% CI: 0.77 to 1.76), body mass index (mean difference: 0.35; 95% CI: -0.86 to 1.57), preoperative coronary artery disease (OR: 2.10; 95% CI: 0.85 to 5.21), stroke (OR: 0.90; 95% CI: 0.50 to 1.59) and preoperative statins intake (OR: 0.65; 95% CI: 0.21 to 2.02) were not associated with POAMI. Patients with POAMI had higher preoperative hsTnT levels (mean difference: 5.92 ng/L; 95% CI: 4.17 to 7.67) and lower preoperative hemoglobin levels (mean difference: -1.29 g/dL; 95% CI: -1.43 to -1.15) than patients without.

Conclusion
Based on this meta-analysis, approximately 1 in 5 of noncardiac patients develop POAMI. However, the lack of a universally recognized definition for POAMI, which incorporates diverse cardiac biomarkers and patient groups, poses a challenge in accurately characterizing its incidence, risk factors, and clinical outcomes.
Monitoring medicine prescriptions before, during and after pregnancy in Italy
Authors: Fortinguerra Filomena , Belleudi Valeria , Poggi Francesca Romana , Perna Serena , Bortolus Renata , Donati Serena , D’Aloja Paola , Da Cas Roberto , Clavenna Antonio , Locatelli Anna , Addis Antonio , Davoli Marina , Trotta Francesco ,   MoM-Net group
Published: June 2023

BackgroundThe use of medications during pregnancy is a common event worldwide. Monitoring medicine prescriptions in clinical practice is a necessary step in assessing the impact of therapeutic choices in pregnant women as well as the adherence to clinical guidelines. The aim of this study was to provide prevalence data on medication use before, during and after pregnancy in the Italian population.MethodsA retrospective prevalence study using administrative healthcare databases was conducted. A cohort of 449,012 pregnant women (15–49 years) residing in eight Italian regions (59% of national population), who delivered in 2016–2018, were enrolled. The prevalence of medication use was estimated as the proportion (%) of pregnant women with any prescription.ResultsAbout 73.1% of enrolled women received at least one drug prescription during pregnancy, 57.1% in pre-pregnancy and 59.3% in postpartum period. The prevalence of drug prescriptions increased with maternal age, especially during the 1sttrimester of pregnancy. The most prescribed medicine was folic acid (34.6%), followed by progesterone (19%), both concentrated in 1sttrimester of pregnancy (29.2% and 14.8%, respectively). Eight of the top 30 most prescribed medications were antibiotics, whose prevalence was higher during 2ndtrimester of pregnancy in women ≥ 40 years (21.6%). An increase in prescriptions of anti-hypertensives, antidiabetics, thyroid hormone and heparin preparations was observed during pregnancy; on the contrary, a decrease was found for chronic therapies, such as anti-epileptics or lipid-modifying agents.ConclusionsThis study represents the largest and most representative population-based study illustrating the medication prescription patterns before, during and after pregnancy in Italy. The observed prescriptive trends were comparable to those reported in other European countries. Given the limited information on medication use in Italian pregnant women, the performed analyses provide an updated overview of drug prescribing in this population, which can help to identify critical aspects in clinical practice and to improve the medical care of pregnant and childbearing women in Italy.