bluuebunny/crossref_metadata_2025_split huggingface dataset:
Donating a Kidney to a Stranger: Are Healthcare Professionals Facilitating the Journey? Results From the BOUnD Study
Authors: Maple Hannah , Gogalniceanu Petrut , Gare Rebecca , Burnapp Lisa , Draper Heather , Chilcot Joseph , Norton Sam , Mamode Nizam 
Published: May 2023

Unspecified kidney donors (UKDs) are approached cautiously by some transplant professionals. The aim of this study was to interrogate the views of UK transplant professionals towards UKDs and identify potential barriers. A purposely designed questionnaire was validated, piloted and distributed amongst transplant professionals at each of the 23 UK transplant centres. Data captured included personal experiences, attitudes towards organ donation, and specific concerns about UKD. 153 responses were obtained, with representation from all UK centres and professional groups. The majority reported a positive experience with UKDs (81.7%; p &lt; 0.001) and were comfortable with UKDs undergoing major surgery (85.7%; p &lt; 0.001). 43.8% reported UKDs to be more time consuming and 52% felt that a mental health assessment should take place before any medical tests. 77% indicated the need for a lower age limit. The suggested age range was broad (16–50 years). Adjusted mean acceptance scores did not differ by profession (p = 0.68) but higher volume centres were more accepting (46.2 vs. 52.9; p &lt; 0.001). This is the first quantitative study of acceptance by transplant professionals to a large national UKD programme. Support is broad, however potential barriers to donation have been identified, including lack of training. Unified national guidance is needed to address these.
3D convolutional neural networks for detecting intracranial aneurysms on brachiocephalic arteries CTA scans
Authors: Zyablova E. I. , Sinitsa S. G. , Zayats I. A. , Khalafyan A. A. , Kardailskaya D. O. , Porhanov V. A. 
Published: May 2023

Background: Computed tomography angiography (CTA) is the primary and minimally invasive imaging modality currently used for diagnosis and monitoring of intracranial aneurysms as well as preoperative planning of their treatment. However, its interpretation is time-consuming even for specially trained neuroradiologists. Nowadays little is known whether trained neural networks contribute to analyzing medical images and reduce the time to diagnosis, and how effective they are in detecting intracranial aneurysms according to the CTA findings.Objective: To assess the diagnostic value of a convolutional neural network prototype in the intracranial aneurysm detection according to the brachiocephalic arteries CTA findings.Materials and methods: We analyzed the 3D convolutional neural network prototype based at Kuban State University (Krasnodar, Russian Federation).This prototype was to determine the probability of intracranial aneurysms according to the brachiocephalic arteries CTA findings, obtained in the Radiology Department of Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1. The study included 451 CTA scans of 205 patients with confirmed intracranial aneurysms and 246 patients without aneurysms.Results: The sensitivity of the 3D convolutional neural network prototype in the aneurysms detection according to the brachiocephalic arteries CTA findings was 85.1%, the specificity was 95.1%, and the overall accuracy was 91%.Conclusions: The 3D convolutional systems may predict aneurysms with a high accuracy as well as localize them with an accuracy of more than 90%. Such results require a larger dataset.
Studying the Efficacy of Local Hemostatic Agents In Vivo
Authors: Lipatov V. A. , Tsilenko K. S. , Denisov A. A. , Kondakova P. D. 
Published: May 2023

Introduction: In modern clinical practice, there is no common and effective hemostatic agent for solid organs of the abdomen. Local agents such as hemostatic sponges, membranes, powders seem promising. The main advantages of hemostatic powders include relatively high efficacy, portability, versatility, as well as simplicity and low cost of manufacturing.Objective: To study the hemostatic efficacy of hemostatic powders’ samples based on the sodium salt of carboxymethylcellulose (Na-CMC) in an acute in vivo experiment.Materials and methods: The study was based at Kursk State Medical University. Fifty male Wistar rats (weighing 220-239 g) were selected as test animals. They were evenly divided into 5 groups: ARISTA AH, Cutanplast Powder, and Na-CMC hemostatic powders with 3 different dynamic viscosities: low (50-200 cP), medium (400-800 cP) and high (1500-3000 cP). Under general inhalation anesthesia, median laparotomy was performed in Wistar rats, the middle lobe of the liver was removed into the wound, and then marginal tangential resection was performed. We applied hemostatic powders of each group to the resulting wound, and then estimated the bleeding time and the volume of blood loss. We used the Mann-Whitney test (P ≤ .05) to assess the statistical significance of differences between the study groups.Results: We recorded the minimum bleeding time and the smallest volume of blood loss for the samples based on the Na-CMC and found no statistically significant differences between the viscosities groups.Conclusions: With Na-CMC hemostatic powder the bleeding time and the volume of blood loss were reduced by 3.6 and 2.2 times, respectively, comparing to the control group. These results were considered statistically significant (P ≤ .05).
Predictive accuracy of cardiac risk indices for cardiovascular complications in patients undergoing noncardiac surgery
Authors: Sokolov D. A. , Tymoshenko A. L. , Chervyakov Yu. V. , Lonchakova O. M. , Ljuboshevskij P. A. 
Published: May 2023

Objective: To compare predictive accuracy of the American Society of Anesthesiologists (ASA) score and various cardiac risk indices for perioperative cardiovascular (CV) complications in patients undergoing noncardiac surgery.Materials and methods: We examined 243 patients (148 men and 95 women) aged 45 to 84 (66 [60-71] years) prior to their elective oncological and vascular surgery. We assessed patients using the ASA physical status classification system, Revised Cardiac Risk Index (RCRI), Gupta Myocardial Infarct or Cardiac Arrest (MICA) calculator, and Khoronenko cardiac risk index and analyzed perioperative CV complications.Results: We detected complications in 30 (12.3%) patients, with 3 (1.24%) of them having 2 concomitant CV complications. One death (0.41%) was registered. The MICA risk calculator had the highest predictive value (AUC ROC = 0.753). Risk scores over 0.95% discriminated patients with perioperative CV complications with sensitivity and specificity of 73.3% and 67.45%, respectively.Conclusions: We recommend using the MICA risk calculator to predict perioperative CV complications following elective oncological and vascular surgery.
Quantitative assessment of the ischemic damage to the brain parenchyma in patients with acute cerebrovascular accident using the Olea Sphere automated software
Authors: Yasakova E. P. , Shevchenko E. G. , Efimov V. V. , Zyablova E. I. 
Published: May 2023

Objective: To evaluate the capabilities of the Olea Sphere automated software for the quantitative assessment of ischemic damage to the brain parenchyma during computed tomography (CT) in patients with acute cerebrovascular accident and its role in choosing the optimal treatment strategy in everyday clinical practice.Materials and methods: We retrospectively analyzed the data from 129 patients with suspected stroke who underwent perfusion CT within 24 hours of admission to the hospital. The Olea Sphere data were used to assess the volume of the infarct core, which was defined as an area with a relative cerebral blood flow less than 40%, the volume of the penumbra area, where Tmax exceeded 6 s, and ultimately the core-penumbra ratio.Results: With the Olea Sphere automated software, we were able to assess the volume of the ischemic changes in the brain parenchyma, particularly, the average volume of the infarct core in 129 patients was 21.95 (1-206) ml, the average volume of the penumbra area was 57.01 (2-357) ml, the core-penumbra ratio was 2.65, and mean time from CT to the start of treatment was 1.2 (0.9-1.9) hours. This quantitative data processing powered by the Olea Sphere provided the indications for the following endovascular treatment in patients with stroke: thrombus extraction in the acute period was performed in 51 patients (72.8%), transluminal balloon angioplasty with stent placement – in 12 patients (17.1%), and carotid endarterectomy in the long-term period – in 5 (9.6%) patients.Conclusions: We discovered that the Olea Sphere automated software can be used to assess ischemic changes in the brain and to make decisions related to patients with acute cerebrovascular accident in emergency conditions.
Analysis of cranioplasty procedures performed in Novosibirsk from 2016 to 2022
Authors: Mishinov S. V. , Kalinovskiy A. V. , Rzaev J. A. , Zarubin M. N. , Nazarov Zh. A. , Bobylev A. G. , Baranov M. A. , Kiselev R. S. , Chernov S. V. , Stupak V. V. 
Published: May 2023

Background: Studies on reconstructive neurosurgical interventions are always relevant due to the persistence of cranial defects, mainly caused by traumatic brain injuries (TBI). To provide medical care to the patients with cranial defects more efficiently, it is necessary to assess a large number of surgical interventions in studies.Objective: To analyze data on reconstructive neurosurgical interventions performed at Novosibirsk hospitals.Methods: We performed a multicenter observational retrospective non-randomized study of the total cranioplasty surgical interventions from 2016 to 2022. The study involved five neurosurgical departments in Novosibirsk hospitals. In 450 of 673 cases the inclusion criteria were met.Results: The majority of patients (n = 361; 80.2%) underwent surgical interventions in federal health facilities. Urban residents prevailed (n = 260) among the patients who met the inclusion criteria. Craniectomies were mainly indicated for the consequences of TBI (n = 319; 70.9%). Time to cranioplasty ranged from 0.1 to 320 months (mean: 23.9 ± 39.2; median: 11.6 months). There were non-clinically significant differences in terms of primary and reconstructive operations between the defects caused by TBI and other conditions. In 51.1% of cases, we found two features describing the size and complexity of the skull defect. In 19.3% of cases, patients were diagnosed with a skull defect (affected anatomical areas were specified).Conclusions: Over seven years, 450 Novosibirsk residents underwent cranioplasty in five neurosurgical Novosibirsk hospitals (mean: 64.3 surgical interventions a year). Comparing the recent results with previous studies data in terms of performed craniectomies, we found that reconstructive interventions are lacking 99.7 cases per year. To reduce the time to cranioplasty, it is necessary to make a registry of patients with skull defects.
Pelatihan Kader Kelompok Kerja Kesehatan (Pokjakes) dalam Pemantauan Status Gizi Wanita Usia Subur (WUS)
Authors: Puji Afiatna  , Tina Mawardika  , Sugeng Maryanto  , Mulyasari Indri 
Published: May 2023

Nutrition investment on reproductive age women is important for poverty alleviation. Nutritional problems on reproductive age women such as chronic energy deficiency and anemia can continue while they are pregnant until in the 1000 days of life of their babies. It can lead to decrease productivity as adults. Pokjakes in community established to help solve nutritional problems including on reproductive age women. Pokjakes played a role in nutrition screening and report the result to health community center. Based on observation, Pokjakes cadre in RW V Pudakpayung Banyumanik Semarang lack of nutrition screening skills on reproductive age women. This course was conducted using lecture and demonstration method to solve the problem. The course aimed to improve cadre skills and data reported to health community centre more valid. Activity followed by 22 cadres. Skills of cadres increased after training with p<0,05. Course method with lecture and demonstration can improve pokjakes cadres skills on nutrition screening
ABSTRAK
Investasi gizi pada kelompok WUS harus menjadi bagian dalam upaya penanggulangan kemiskinan. Masalah gizi pada kelompok WUS seperti kekurangan energi kronis dan anemia dapat berlanjut pada masa kehamilan dan berlanjut hingga 1000 hari pertama kehidupan bahkan dapat berdampak pada penurunan produktivitas pada usia dewasa. Pokjakes di masyarakat dibentuk untuk membantu memecahkan masalah gizi termasuk WUS salah satunya adalah membantu penapisan gizi untuk dilaporkan ke Puskesmas. Berdasarkan hasil pengamatan, Kader Pokjakes di RW V Kelurahan Pudakpayung, Banyumanik Semarang masih kurang keterampilannya dalam melakukan penapisan gizi pada WUS. Kegiatan pelatihan dengan metode ceramah dan demonstrasi dilaksanakan untuk mengatasi masalah tersebut. Kegiatan dimaksudkan agar keterampilan Kader meningkat dan data yang dilaporkan ke Puskesmas lebih valid. Kegiatan diikuti 22 orang. Keterampilan kader meningkat setelah pelatihan dengan nilai p<0.05. Metode pelatihan dengan ceramah dan demonstrasi dapat meningkatkan keterampilan Kader Pokjakes dalam melakukan penapisan gizi pada WUS.
Kandidat Obat Baru Dan Target Kerja Obat Penyakit Systemic Lupus Erythematosus : Tinjauan Pustaka
Authors: Aribowo Audi Ichsani , Urbaningrum Lestari Mahardika , Sa'adah Cantika Nurul , Annisa Bunga Nur , Sary Nena Vauziah , Lubis Christina Febiola , Nurfadhila Lina , Utami Marsah Rahmawati 
Published: May 2023

Systemic lupus erythematosus (SLE) ialah penyakit dengan kerusakan pada sistem kekebalan tubuh, terutama dalam imunitas seluler dan humoral. SLE terjadi pada individu dengan predisposisi genetik, terutama pada gen HLA yang dipicu oleh faktor lingkungan. Pada kebanyakan kasus, SLE muncul akibat efek dari banyak varian gen. Ada banyak golongan obat yang biasa digunakan untuk pengobatan SLE seperti kortikosteroid, imunosupresan, NSAID, atau antibodi monoklonal spesifik yang diarahkan terhadap reseptor permukaan sel atau sitokin Tujuan dari tinjauan pustaka ini adalah untuk memberikan gambaran dan informasi terkini tentang kandidat obat baru dan target kerja obat penyakit lupus. Metode yang digunakan berupa tinjauan pustaka dari Google Scholar, Science Direct, dan PubMed dengan kriteria inklusi dan eksklusi. Hasil target kerja obat tersebut melalui tiga jenis penelitian berupa in vivo, in vitro, dan in silico. Berdasarkan tinjauan pustaka yang sudah dilakukan, terdapat beberapa target kerja obat pada penyakit lupus/SLE yaitu reseptor PI3Kδ, Enzim NF-κB inducing kinase, IFN-γ, IL-3, TNF-α, TP53, VEGFA, IL6, CD4, CCR1, JAK2, XRCC5, XRCC6, RB1, MYC, TP53, IL-1 alpha, IL-5, IL-6, IL-17, Limfotoxin-alpha, IL-21, TLR7, TLR9, CAPS3, STAT3, STAT1, IFNα, FcγR2A, CD22, CD20. Lalu untuk hasil beberapa kandidat obat baru terdapat pada ekstrak daun Bryophyllum pinnatum, curcumin, Langchuangding, Hedyotis diffusa Willd, dan BIIB059. Semua target atau kandidat senyawa pengobatan lupus yang diteliti memiliki hasil yang baik untuk pengobatan lupus.
Penanganan Rehabilitasi Medik pada Pasca Artrodesis Kaki Charcot Tanpa Komplikasi
Authors: Damopolii Christina A. , Gessal Joudy , Perwira Devan 
Published: May 2023

Impact of diabetes on the occurrence of Charcot's foot provides conservative treatment to the benefits of arthrodesis. Charcot foot is a debilitating joint disease characterized by progressive multiple bone destruction, dislocations, and severe deformities of the foot and ankle. Its prevalence may increase in the general high-risk population. Initial treatment of Charcot foot is often conservative and involves the use of bracing, casting, and special orthopedic shoes. This intervention allows the patient to functionally ambulate without resorting to more invasive interventions. Arthrodesis is an effective limb-saving method for patients with Charcot neuroarthropathy who have severe deformity and instability. This technique is usually used for chronic cases with irreversible deformity and/or joint instability to increase plantar pressure and balance of the foot and to minimize the risk of foot ulceration and amputation. In conclusion, non-weight bearing treatment dan immobilisation are the most effective rehabilitation management for active-phase Charcot foot accompanied by surgery consideration to maximize the functional of the foot.
Keywords: Charcot foot; diabetes; arthrodesis; rehabilitation management

Abstrak: Diabetes berdampak terhadap terjadinya kaki Charcot dengan penanganan secara konservatif hingga tindakan artrodesis. Kaki Charcot merupakan salah satu penyakit sendi yang merusak dan ditandai dengan progresifitas kerusakan tulang multipel, dislokasi dan deformitas parah pada kaki dan pergelangan kaki dengan prevalensi yang meningkat pada populasi dengan risiko tinggi. Perawatan awal kaki Charcot seringkali konservatif dan melibatkan penggunaan bracing, casting, dan sepatu ortopedi khusus. Intervensi ini memungkinkan pasien untuk ambulasi secara fungsional tanpa menggunakan intervensi yang lebih invasif. Artrodesis merupakan metode penyelamatan anggota tubuh yang efektif untuk pasien dengan neuropati Charcot yang memiliki deformitas parah dan ketidakstabilan. Teknik ini biasanya digunakan untuk kasus kronis dengan deformitas ireversibel dan/atau ketidakstabilan sendi untuk meningkatkan tekanan dan keseimbangan plantar kaki dan untuk meminimalkan risiko ulserasi dan amputasi kaki. Simpulan studi ini ialah penanganan non-weight bearing dan imobilisasi merupakan penanganan rehabilitasi untuk kaki Charcot fase aktif dengan pertimbangan tindakan pembedahan untuk memaksimalkan fungsi kaki.
Kata kunci: kaki Charcot; diabetes; arthrodesis; penanganan rehabilitasi
Solid phase epitaxy of perpendicular magnetic BaFe12O19 flexible sheets on a mica substrate
Authors: Katayama Tsukasa , Mo Shishin , Chikamatsu Akira , Hasegawa Tetsuya 
Published: May 2023

Abstract
Epitaxial M-type BaFe12O19 flexible sheets, exhibiting RT perpendicular magnetization, were synthesized on mica substrates through the solid phase epitaxy method. The [110] and [001] directions of the BaFe12O19 layer were parallel to the [010] and [001] directions of the mica, respectively. In the synthesis process, amorphous BaFe12O19 films were firstly prepared on Al2O3-buffered mica (001) substrates and then annealed at 800 °C–900 °C in air for single crystallization. During optimization of the synthesis, we found that preparation of the buffer layer and controlling annealing temperature are important for obtaining the epitaxial sheet. The sheets exhibited perpendicular ferrimagnetism with large saturated magnetization (60 Am2 kg−1) and magnetic anisotropy coefficient (2.1 × 105 J m−3) at 300 K, together with flexibility.
Pseudomorphic growth of Si-doped α-(AlGa)2O3 on m-plane α-Al2O3 substrates by molecular beam epitaxy
Authors: Okumura Hironori 
Published: May 2023

Abstract

α-(AlGa)2O3 is an attractive material for high-power devices and vacuum UV optoelectronics. However, α-(AlGa)2O3 on sapphire substrates suffers from lattice relaxation and phase transformation. Here, we investigated the effect of controlling the Al composition and thickness of Si-doped α-(AlGa)2O3 layers pseudomorphically grown on α-Al2O3 (10

1
¯

0) substrates by MBE. We found that the critical layer thicknesses of α-(AlGa)2O3 layers with Al compositions of 58%, 66%, and 79% were around 13, 18, and 44 nm, respectively. We also found that a 9.0 nm thick α-(Al0.65Ga0.35)2O3/3.5 nm thick Al2O3 multilayer with 20 periods grew almost pseudomorphically and formed α-(Al0.90Ga0.10)2O3 alloy after post-thermal annealing at 1400 °C.
Suppression of high-temperature thermal conductivity due to electron-lattice coupling in PrAlO3, Tb2Ti2O7, and Dy3Al5O12
Authors: Tachibana Makoto , Bourgès Cédric , Mori Takao 
Published: May 2023

Abstract
Thermal conductivities (κ) above 300 K are presented for a series of RAlO3 perovskites, R
2Ti2O7 pyrochlores, and R
3Al5O12 garnets, where R is a rare earth. We find unusual temperature dependence and suppression of κ in PrAlO3, Tb2Ti2O7, and Dy3Al5O12, which arise from interactions between the lattice phonons and electronic energy levels of R ions. These results indicate that proper consideration of electron-lattice coupling is necessary in assessing the high-temperature κ of R-based oxides, which are widely being examined for applications to thermal barrier coatings.
MEMBANGUN PEMASARAN ONLINE DAN DIGITAL BRANDING DITENGAH PANDEMI COVID-19
Authors: Fadly Hawangga Dhiyaul , Sutama Sutama 
Published: May 2023

Salah satu dari dampak dari pendemi COVID-19 adalah kemrosotan dalam dunia bisnis dan ekonomi. Dengan demikian pemasar maupun pengusaha harus menemukan alternatif solusi untuk bisa memasarkan produk atau jasa mereka ke konsumen. Para pelaku bisnis mengoptimalkan pemasaran online dan digital branding sebagai sarana komunikasi dengan target konsumennya. Hal ini tentunya menjadi pilihan yang sangat efektif dimasa pandemi ini. Tujuan penelitian pada artikel ini ada dua. 1) Â menganalisis pemasaran online dan digital branding. 2) Mendeskripsikan pemasaran online dan digital branding ditengah pandemi COVID 19. Jenis penelitian ini adalah penelitian referensi yang pengambilan datanya berorientasi pada beberapa referensi yang sesuai. Fokus penelitian ini adalah membangun pemasaran online dan digital branding ditengah pandemi COVID-19. Keabsahan data dalam artikel ini adalah dengan berbagai sumber dan perpanjangan waktu. Teknik analisis data pada artikel ini adalah dengan menggunakan metode komparasi konstanta. Adapun hasil dari penelitian pada artikel ini ada dua. 1) Analisis pemasaran online dan digital branding. 2) Mendeskripsikan pemasaran online dan digital branding ditengah pandemi COVID 19.
KEPEMIMPINAN TRANSFORMASIONAL DALAM MANAJEMEN SUMBER DAYA MANUSIA (STUDI KASUS APARATUR SIPIL NEGARA PEMERINTAH KOTA KUPANG NUSA TENGGARA TIMUR)
Authors: Riwukore Jefirstson Richset , Alie Marzuki , Habaora Fellyanus 
Published: May 2023

The purpose of this research was to measure the principles of transformational leadership in human resource management. This research was conducted for 7 (seven) months from September 2019 to February 2020 at the Regional Government Secretariat of Kupang City (Pemkot Kupang) East Nusa Tenggara (NTT) Indonesia. The population of respondents in this study were the State Civil apparatus (ASN) within the scope of the Kupang City Government, East Nusa Tenggara, group I to group IV, totaling 370 ASN Kupang City government consisting of ASN group I as many as 8 of respondents, ASN group II as many as 80 of respondents, group III as many as 215 of respondents, and group IV as many as 67 of respondents. The type of data in this study consists of primary data and secondary data. The analysis used in this research is descriptive analysis with data processing and analysis using a Likert scale. The results showed that the transformational leadership within the City Government by policy makers has generally been implemented well. This can be seen from the ability to build a vision, inspirational communication, leaders who provide support, increase in intellectual abilities, and respect for individuals.Â Keywords: transformational leadership, state civil apparatus, Kupang City Government