bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fractura intergeneracional en la cadena de cuidados familiares de las personas con Alzheimer. Necesidad de un modelo profesionalizado de cuidados
Authors: García Martinez Jesús , Kolly Pilar 
Published: July 2023

Introducción. Las atenciones en el ámbito familiar para con las personas que presentan alzhéimer son protagonizadas mayoritariamente por mujeres; como consecuencia de las asimetrías de género en los cuidados. El objetivo es analizar la actual insostenibilidad en el tiempo de dicho modelo debido al cambio de expectativas y valores por parte de las nuevas generaciones de mujeres. Metodología. Es de carácter cualitativo, se ha procedido a entrevistar a 16 mujeres –cónyuges- que proporcionan con exclusividad estas atenciones; así como el análisis discursivo de un grupo de discusión, conformado por 10 mujeres jóvenes, a modo de contraste. Resultados.Nuestra investigación muestran que la mujer cuidadora constituye, en estos momentos, la base principal para la atención y respuesta de las necesidades de las personas dependientes con alzhéimer. Dichas atenciones exigentes y prolongadas en el tiempo aumentan de forma progresiva e inexorable el estrés físico y psíquico de estas mujeres en el ejercicio de sus responsabilidades familiares. Discusión. Se apunta al hecho que la crisis en el modelo de cuidados de alta exigencia, dependientes con la enfermedad de alzhéimer, evidencia tanto la insostenibilidad de dicho modelo -falta de relevo generacional debido al cambio de expectativas vitales por las mujeres jóvenes-, como las limitaciones inherentes de las cuidadoras mayores en una praxis de cuidados altamente exigente. Se constata, simultáneamente, la crisis actual de estos modos de cuidados de alta exigencia en lo relativo a su sostenibilidad en el tiempo. Es decir, la debilidad interna, tal como está organizado socialmente, resulta insostenible en el tiempo, debido a la ruptura intergeneracional entre madres e hijas en la provisión de cuidados familiares de alta exigencia. Conclusiones. Nuestra conclusión referencia la necesidad de un cambio de paradigma en la actual provisión de atenciones en el ámbito familiar que permita un nuevo modelo profesionalizado en la provisión de servicios lo que permitirá desactivar el efecto género en dichos cuidados de alta exigencia. Es necesario e inaplazable la re-construcción de los discursos y prácticas en el contexto de los cuidados de alta exigencia. Si se consigue desactivar el actual asimetría en los cuidados familiares, desde un enfoque de género, se estará contribuyendo a la construcción de una sociedad más equitativa e igualitaria.
Geometrically non-linear analysis with stiffness reduction for the in-plane stability design of stainless steel frames
Authors:   , Shen Yanfei 
Published: July 2023

In AISC 360-16, the Direct Analysis Method (DM) has been set as the primary method for the stability design of frames. DM, considering initial global sway imperfection, is essentially Geometrically Non-linear Analysis (GNA) in which tangent modulus is used. The aim of this thesis is to provide stiffness reduction factor formulations for using GNA coupled with tangent modulus approach for the stability design of stainless steel frames. GNA with the proposed stiffness reduction factor is aligned to AISC 360-16 and it is aimed at facilitating greater and more efficient use of stainless steel. In accordance with current design standards, the ultimate limit state for this method is the formation of first plastic hinge, and the adequacy of the method is confirmed through member-based resistance checks.The focus of the thesis is the development of flexural stiffness reduction factor formulation for the in-plane stability design of stainless steel elements and frames with cold-formed square hollow section (SHS) and rectangular hollow section (RHS). The proposed beam-column stiffness reduction factor (tMN) accounts for the deleterious influence of material non-linearity, residual stresses and member out-of-straightness. The use of a GNA coupled with the proposed tMN eliminates the need for member buckling strength checks and thus, only cross-sectional strength checks are required.
En la normativa Americana AISC 360-16, el método de análisis directo (DM) se ha establecido como el método principal en la verificación a inestabilidad de pórticos. El DM es esencialmente un análisis no lineal por la geometría (GNA) en el que se consideran las imperfecciones globales únicamente y se utiliza el módulo tangente. El objetivo de la tesis es proporcionar una formulación de rigidez reducida utilizando un análisis no lineal por la geometría para las verificaciones a inestabilidad de pórticos de acero inoxidable. El método propuesto se alinea con el AISC 360-16 y su objetivo es facilitar el uso del acero inoxidable en pórticos. De acuerdo con las normativas actuales, la capacidad última de un pórtico se define al formarse la primera rótula plástica y la verificación se plantea en base a la resistencia de los elementos aislados. El foco de la tesis se centra en el plantramiento de factores de reducción de rigidez a flexión de elementos tubulares de acero inoxidable conformados en frío (SHS y RHS) para el caso de diseño de pórticos cargados en su plano. Se propone un factor de reducción para elementos del tipo viga-columna mn el cual tiene en cuenta los efectos de la nolinealidad del material, las tensiones residuales y la imperfección del elemento. El uso de GNA conjuntamente con tMN permite verificar los diferentes elementos del pórtico solo a resistencia sin tener hacer las comprobaciones correspondientes a pandeo.
Sistema socio-productivo y modelo de gobernanza en la comunidad kichwa “Shiwakucha”, Pastaza, Ecuador
Authors: Ospina Vanessa , Torres Navarrete Segundo Bolier , Köthke Margret , Kapp Gerald , Fischer Richard , Günter Sven 
Published: July 2023

Los kichwa son una de las 14 nacionalidades del Ecuador con mayor población indígena en el país, específicamente localizados en las regiones Andina y Amazónica. En esta última, se encuentran asentados con mayor proporción en las provincias de Napo, Orellana y Pastaza. La presente investigación analiza las interacciones entre los sistemas socio-ecológicos y productivos en la comunidad kichwa de Shiwakucha, caracterizada por ser una comunidad de fácil y constante acceso por su localización a solo 12,8 km con respecto al centro urbano del cantón Arajuno, provincia de Pastaza. La mayoría de los miembros de Shiwakucha pertenecen al mismo grupo étnico y manejan su territorio de manera colectiva y bajo la protección de la Asociación de líderes indígenas ACIA. La fase de campo se desarrolló en dos meses de trabajo con métodos cualitativos (entrevistas semi estructuradas), cartografía social con caminatas geo-referenciadas, diálogo y observación participante, también se usó métodos cuantitativos a través de encuestas aplicados al 89% de los hogares permanente de la comunidad. Los resultados muestran que en Shiwakucha el 47 % de la población que vive permanentemente en la comunidad es bilingüe (castellano/ kichwa), el 33% exclusivamente usan el idioma kichwa y el 20% principalmente castellano. La población masculina tiene mayor contacto y posibilidades de educación superior. Shiwakucha muestra una diversificación de actividades económicas, donde la agricultura es el principal medio de vida, expresado en la mezcla de prácticas agrícolas exógenas, con modelos tradicionales como la chakra kichwa, donde se utilizan en promedio 2,9 ha de cultivos y 20,3 ha de bosque intervenido a nivel de hogar. Con respecto al sistema de gobernanza, la comunidad se encuentra dentro del territorio de la Asociación de Comunidades Indígenas de Arajuno (ACIA), que surge como ente regulador y protector de las tierras indígenas en los 70s como respuesta a la reforma agraria; se encontró que por esta y otras razones la comunidad presenta una combinación de normas indígenas con reglas adoptadas por la nueva integración dentro de la ACIA y otras normas exógenas. Aspectos sobre la nueva reconfiguración en el territorio sobre la vía de acceso y el remplazo de actividades de agricultura de subsistencia por monocultivos con implicaciones sobre la seguridad alimentaria son discutidos.
CAM-YOLO: tomato detection and classification based on improved YOLOv5 using combining attention mechanism
Authors: Appe Seetharam Nagesh , G Arulselvi , GN Balaji 
Published: July 2023

Background
One of the key elements in maintaining the consistent marketing of tomato fruit is tomato quality. Since ripeness is the most important factor for tomato quality in the viewpoint of consumers, determining the stages of tomato ripeness is a fundamental industrial concern with regard to tomato production to obtain a high quality product. Since tomatoes are one of the most important crops in the world, automatic ripeness evaluation of tomatoes is a significant study topic as it may prove beneficial in ensuring an optimal production of high-quality product, increasing profitability. This article explores and categorises the various maturity/ripeness phases to propose an automated multi-class classification approach for tomato ripeness testing and evaluation.

Methods
Object detection is the critical component in a wide variety of computer vision problems and applications such as manufacturing, agriculture, medicine, and autonomous driving. Due to the tomato fruits’ complex identification background, texture disruption, and partial occlusion, the classic deep learning object detection approach (YOLO) has a poor rate of success in detecting tomato fruits. To figure out these issues, this article proposes an improved YOLOv5 tomato detection algorithm. The proposed algorithm CAM-YOLO uses YOLOv5 for feature extraction, target identification and Convolutional Block Attention Module (CBAM). The CBAM is added to the CAM-YOLO to focus the model on improving accuracy. Finally, non-maximum suppression and distance intersection over union (DIoU) are applied to enhance the identification of overlapping objects in the image.

Results
Several images from the dataset were chosen for testing to assess the model’s performance, and the detection performance of the CAM-YOLO and standard YOLOv5 models under various conditions was compared. The experimental results affirms that CAM-YOLO algorithm is efficient in detecting the overlapped and small tomatoes with an average precision of 88.1%.
Evaluating Access to Laser Eye Surgery by Driving Times Using Medicare Data and Geographical Mapping
Authors: Shaffer Jamie , Rajesh Anand , Stewart Michael W. , Lee Aaron Y. , Miller Darby D. , Lee Cecilia S. , Francis Courtney E. 
Published: July 2023

ImportanceRecently, several states have granted optometrists privileges to perform select laser procedures (laser peripheral iridotomy, selective laser trabeculoplasty, and YAG laser capsulotomy) with the aim of increasing access. However, whether these changes are associated with increased access to these procedures among each state’s Medicare population has not been evaluated.ObjectiveTo compare patient access to laser surgery eye care by estimated travel time and 30-minute proximity to an optometrist or ophthalmologist.Design, Setting, and ParticipantsThis retrospective cohort database study used Medicare Part B claims data from 2016 through 2020 for patients accessing new patient or laser eye care (laser peripheral iridotomy, selective laser trabeculoplasty, YAG) from optometrists or ophthalmologists in Oklahoma, Kentucky, Louisiana, Arkansas, and Missouri. Analysis took place between December 2021 and March 2023.Main Outcome and MeasuresPercentage of each state’s Medicare population within a 30-minute travel time (isochrone) of an optometrist or ophthalmologist based on US census block group population and estimated travel time from patient to health care professional.ResultsThe analytic cohort consisted of 1 564 307 individual claims. Isochrones show that optometrists performing laser eye surgery cover a geographic area similar to that covered by ophthalmologists. Less than 5% of the population had only optometrists (no ophthalmologists) within a 30-minute drive in every state except for Oklahoma for YAG (301 470 [7.6%]) and selective laser trabeculoplasty (371 097 [9.4%]). Patients had a longer travel time to receive all laser procedures from optometrists than ophthalmologists in Kentucky: the shortest median (IQR) drive time for an optometrist-performed procedure was 49.0 (18.4-71.7) minutes for YAG, and the the longest median (IQR) drive time for an ophthalmologist-performed procedure was 22.8 (12.1-41.4) minutes, also for YAG. The median (IQR) driving time for YAG in Oklahoma was 26.6 (12.2-56.9) for optometrists vs 22.0 (11.2-40.8) minutes for ophthalmologists, and in Arkansas it was 90.0 (16.2-93.2) for optometrists vs 26.5 (11.8-51.6) minutes for ophthalmologists. In Louisiana, the longest median (IQR) travel time to receive laser procedures from optometrists was for YAG at 18.5 (7.6-32.6) minutes and the shortest drive to receive procedures from ophthalmologists was for YAG at 20.5 (11.7-39.7) minutes.Conclusions and RelevanceAlthough this study did not assess impact on quality of care, expansion of laser eye surgery privileges to optometrists was not found to lead to shorter travel times to receive care or to a meaningful increase in the percentage of the population with nearby health care professionals.
An intramolecular energetic network regulates ligand recognition in a SH2 domain
Authors: Nardella Caterina , Pagano Livia , Pennacchietti Valeria , Felice Mariana Di , Matteo Sara Di , Diop Awa , Malagrinò Francesca , Marcocci Lucia , Pietrangeli Paola , Gianni Stefano , Toto Angelo 
Published: July 2023

AbstractIn an effort to investigate the molecular determinants of ligand recognition of the C‐terminal SH2 domain of the SHP2 protein, we conducted extensive site‐directed mutagenesis and kinetic binding experiments with a peptide mimicking a specific portion of a physiological ligand (the scaffold protein Gab2). Obtained data provided an in‐depth characterization of the binding reaction, allowing us to pinpoint residues topologically far from the binding pocket of the SH2 domain to have a role in the recognition and binding of the peptide. The presence of a sparse energetic network regulating the interaction with Gab2 was identified and characterized through double mutant cycle analysis, performed by challenging all the designed site‐directed variants of C‐SH2 with a Gab2 peptide mutated at +3 position relative to its phosphorylated tyrosine, a key residue for C‐SH2 binding specificity. Results highlighted non‐optimized residues involved in the energetic network regulating the binding with Gab2, which may be at the basis of the ability of this SH2 domain to interact with different partners in the intracellular environment. Moreover, a detailed analysis of kinetic and thermodynamic parameters revealed the role of the residue at +3 position on Gab2 in the early and late events of the binding reaction with the C‐SH2 domain.
The dental system of †Kazanichthys viatkensis (Actinopterygii, Acrolepididae) from the middle Permian of European Russia: palaeobiological and palaeoecological inferences
Authors: Bakaev Aleksandr S. , Johanson Zerina , LeBlanc Aaron 
Published: July 2023

AbstractAmong ray‐finned fishes (Actinopterygii), the crushing, durophagous feeding strategy first evolved in the early Carboniferous period, with the †Eurynotiformes possessing dentitions with single layers of partially to fully fused blunt teeth. In the †‘Platysomidae’ (Permian), a new form of crushing dentition evolved (phyllodonty), in which multiple layers of superimposed crushing teeth developed intraosseously, within the jaw. The phyllodont durophagous dentition is also recovered from later‐occurring taxa originating mainly in the Mesozoic, such as the †Bobastraniiformes, the neopterygians †Pycnodontiformes and Ginglymodi, and in the teleost group †Phyllodonta. By comparison, †Kazanichthys viatkensis, an actinopterygian from the middle Permian of European Russia, is characterized by a third, putatively durophagous dentition, with anterior conical teeth and closely packed molariform teeth on the buccal dental plates (a potential similarity with eurynotiforms). Whereas the conical teeth are similar to those of basal actinopterygians, the molariform teeth superficially resemble teeth of some teleosts (Characiformes, Tetraodontiformes), but are unique among known fossil and living Actinopterygii in being crowned by anastomosing, sharp apical ridges. Teeth are ankylosed to the jaw and acrodont in implantation. There is neither evidence of plicidentine, nor cavities corresponding to intraosseous crypts. Most replacement teeth formed extraosseously, differing from the phyllodont dentition, but similar to several more phylogenetically basal actinopterygians. The dental system morphologically resembles recent Sparidae (Teleostei; Perciformes), possibly indicating a similar trophic adaptation. Based on these comparisons and patterns of wear, we propose that †K. viatkensis was a generalist durophagous feeder, with the ability to switch prey types with its unique and complex dentition.
Evaluating the Application of a Gap‐Fill Exercise on the Learning of Phrasal Verbs: Do Errors Help or Hinder Learning?
Authors: Strong Brian , Leeming Paul 
Published: July 2023

AbstractIn recent years, there has been considerable interest in how to maximize learners' retention of multiword expressions. One technique that has been shown to be highly effective is the use of exercises such as those found in mainstream English as a second language textbooks. In the present study, we investigated how the execution of a gap‐fill exercise impacts the learning of phrasal verbs with 118 learners studying English as a foreign language. Participants completed a gap‐fill exercise by referring to the answer key, or they received the answer key only after completing the exercise. The effects of the learning conditions were assessed with tests for measuring productive and receptive knowledge at two retention intervals. The results from mixed‐effects logistic regression modeling showed that both executions of the gap‐fill exercise led to similar rates of retention. The findings largely challenge previous research. We also explored how to minimize proactive interference when participants make errors in gap‐fill exercises by asking them to recollect their initial guesses during the posttests. The results showed that when the initial guess was produced, correct recall of the target phrasal verbs was much greater than when the guess was not recollected. The finding indicates that memory for the initial guess may play a vital role in how participants learn from their errors. The pedagogical implications of the findings are discussed, and future areas of research are proposed.
Health anxiety and the negative interpretation of children’s bodily symptoms in mothers of cancer patients
Authors: Hosseinchi Parham , Ghalibaf Erfan , Kamyab Golnoosh , Eghbali Aziz , Khatibi Ali 
Published: July 2023

Abstract
Purpose
Fear of progression (FoP) is a substantial concern for family caregivers of cancer survivors and is related to a number of adverse outcomes, including increased mental distress and worse quality of life. Previous research has revealed that health anxiety (HA) contributes to fear of relapse, but cognitive factors underlying establishing and maintaining FoP in mothers of cancer patients have not been examined. In this study, we were looking to investigate this association.

Methods
We used the computerized interpretation bias (IB) assessment to investigate the biased interpretation of ambiguous bodily information and its association with FoP through HA among 69 mothers of cancer patients and 42 mothers of healthy kids.

Results
Mothers of cancer patients interpreted more negatively ambiguous bodily symptoms than mothers of healthy kids. Moreover, they had higher levels of HA and FoP and lower quality of life than the healthy group. Also, among mothers of cancer patients, the relationship between negative IB and FoP is mediated by their HA.

Conclusions
The findings of this study imply that negative IB may contribute to increased HA, which in turn contributes to higher levels of FoP among the mothers of cancer patients, which may reduce the quality of life of their children.

Implications for Cancer Survivors
From these findings, we propose that changing HA through modification of IB might lower the FoP in mothers of kids with cancer and improve the mother and child’s quality of life.
Effektive antidiabetische Therapie zur Vorbeugung einer diabetischen Nephropathie
Authors: Müller Nicolle , Busch Martin , Gerdes Christian , Wolf Gunter 
Published: July 2023

ZUSAMMENFASSUNGDie chronische Nierenkrankheit (CKD: „chronic kidney disease“) stellt eine der häufigsten Folgekomplikationen bei Menschen mit Diabetes mellitus dar und erhöht exzessiv die Morbidität und Mortalität. Daher ist die Vorbeugung einer Nephropathie von klinischer Bedeutung. Im Mittelpunkt der Therapie stand in den letzten Jahren die antihypertensive und nephroprotektive Therapie mit ACE-Hemmern (ACE: „angiotensin converting enzyme“) oder ATII1-Rezeptor-Antagonisten (ATII1: Angiotensin-II-Rezeptor Subtyp-1; Blockade des Renin-Angiotensin-Systems (RAS)) in der Kombination mit einer antiglykämischen und lipidsenkenden Therapie im Rahmen eines multimodalen Therapiekonzepts. Inzwischen zeigen Antidiabetika signifikante und intrinsische nephroprotektive Effekte, die über die reine Glukosesenkung hinausgehen. Als besonders potent haben sich dabei Hemmer des Natrium-Glukose-Kotransporters 2 (SGLT-2: „sodium glucose linked transporter 2“) und GLP1-Rezeptor-Agonisten (GLP1: „glucagon-like peptide 1“) herausgestellt. GLP1-Rezeptor-Agonisten reduzieren vor allem die Albuminurie bei Menschen mit Typ-2-Diabetes. SGLT-2-Hemmer verlangsamen auch den Abfall der glomerulären Filtrationsrate (GFR) über die Zeit und konnten diesen nephroprotektiven Effekt sowohl bei Menschen mit Diabetes als auch bei jenen ohne Diabetes zeigen. Entsprechend wird in Leitlinien für Menschen mit Diabetes mellitus Typ 2 und CKD oder erhöhtem kardialen Risiko empfohlen, neben Metformin und der RAS-Blockade, die Therapie mit SGLT-2-Hemmern und – sofern zur Glykämiesenkung notwendig – additiv GLP1-Rezeptor-Agonisten anzuwenden.