bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Kit: Undergraduate Students Identifying and Mitigating Barriers to their Sexual and Reproductive Health Needs
Authors: Olson Rachel , Lehman Jonathan , Mejia Angie , Ojeikhodion Rachael , Osiecki Kristin , Kathambi Emily , Kati Silas Swarnakanth , Randolph Anita 
Published: August 2023

Abstract
Background
Many U.S. colleges and universities offer access to a healthcare center that provides sexual and reproductive health (SRH) resources, services, and products. The importance of health centers in college and university settings in reducing sexual health disparities in student populations cannot be stressed enough. This article evaluates a student-led, mutual-aid, grassroots health promotion strategy for students with limited access to healthcare services, supplies, and tools, via an anonymous and discrete distribution of SRH resources without charge.
Methods
In partnership with faculty, undergraduate students worked to address their SRH needs by providing and increasing access to comprehensive, evidence-based, and sex-positive resources. Referred to as The Kit, this student-led, grassroots health promotion program aimed to provide contraceptives, sexual health wellness products, and basic hygiene supplies to students in 2022–2023. This pilot study aimed to assess student-perceived availability and barriers to contraception and desired SRH services on campus, implement a low-cost and sex-positive intervention, and elucidate perceptions of the program's availability, use, and impact. Association rules mining identified associations between the types of SRH products that were requested in tandem by students.
Results
Our findings highlight students’ perception of access to services and resources and the implementation of an anonymous and discreet SRH supplies distribution strategy to meet the articulated needs of undergraduate students. Students reported cost, privacy, and confidentiality as significant barriers to acquiring sexual health products and supplies. The Kit was made available for one academic year and has gained student popularity and growth in awareness of what it provides. Survey data reveals that before the implementation of The Kit, 42% of students reported contraceptives being available on campus, and one-year post-intervention, that number grew to 71%. Similar observations were made for student access to sexual health education (29% and 72% report access, respectively) and services (35% and 72% report access, respectively) pre-and post-intervention.
Conclusion
A student-led SRH supply and resource delivery strategy may immediately reduce SRH inequities and decrease barriers to contraceptive use for students with limited access to on-site SRH product availability.
Effectiveness of Aerobic Exercise Intervention on Cardiovascular Disease Risk in Female Breast Cancer: A Systematic Review with Meta-analyses
Authors: Jiao Qian , Xu Bowen , Meng Chao , Xu Fan , Li Shanshan , Zhong Jiayi , Yang Min , Li Jiang , Li Haixia 
Published: August 2023

Abstract
Background
Cardiovascular disease (CVD) has become the leading cause of competitive mortality in female breast cancer (BC). Regular aerobic exercise (AE) has been widely accepted as an effective intervention to reduce cardiovascular risk in a variety of different clinical conditions. This study is aimed at evaluating the efficacy and safety of AE on cardiovascular risk factors in female BC and assessing the quality of the synthesized evidence.
Methods
We searched five English databases (Cochrane Library, PubMed, Embase, Scopus, and Web of Science) from inception to January 2023. Randomized controlled trials (RCTs) and cohort trials studying the effects of AE were included. We used Stata 16 for data synthesis, Risk of Bias 2, and the Newcastle-Ottawa Scale for methodological quality evaluation and assessed the certainty of the synthesized evidence in the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.
Results
Forty RCTs and 6 cohort trials involving 59,050 BC patients showed AE reduced the incidence of CVD events by 29.4% [RR = 0.706, 95% CI (0.659, 0.757), low certainty] and coronary artery disease events by 36% (risk ratio [RR]: 0.64, 95% confidence interval [CI] [0.561, 0.729]; risk difference [RD] = 23.2%, 95% CI [17.6%, 29.6%], low certainty]. AE improved LVEF, and reduced weight and hip circumference. The subgroup analysis results showed that nonlinear AE increased VO2max by 5.354 ml·kg·min− 1 [MD 5.354, 95% CI (2.645, 8.062), very low certainty] and reduced fat mass by 4.256 kg [MD 4.256, 95% CI (-3.839, -0.094), very low certainty]. While linear AE reduced low-density lipoprotein cholesterol (LDL-C) by 8.534 mg/dL [MD -8.534, 95% CI (-15.511, -1.557), low certainty]. The sensitivity analysis results showed that each trial did not affect the impact index of the highly heterogeneous outcomes.
Conclusions
Our study indicates that AE has a positive effect in reducing cardiovascular risk factors. The principles of AE especially nonlinear design deserve more attention in the future. This will provide new ideas to reduce CVD events and improve the quality of life in female BC patients. However, further research on AE in female BC should take into account long-term and well-designed administration to draw definitive conclusions.
Analyzing the Salivary Levels of Cathepsin B in Oral Submucous Fibosis and Oral Squamous Cell Carcinoma for Early Detection
Authors: Ahmed Shaheen , Shabbir Alveena , Shaikh Abdul , Jamil Soofia , Shaikh Sabhita , Farooqui Waqas 
Published: August 2023

Abstract
Background:
Oral squamous cell carcinoma is one of the most prevalent and common cancers of oral cavity with significant higher rates of mortality and morbidity. Many of the OSCC are known to be preceded by oral potentially malignant disorders such as Oral Submucous Fibrosis. OSF is a chronic and insidious condition with a high malignant transformation potential into OSCC. Salivary biomarker analysis has been considered as a promising approach for early detection of malignant potential of OSF. Cathepsin B is a lysosomal cysteine protease. In many malignancies increased levels of Cathepsin B were observed including OSCC. The present study was designed to analyze and determine the salivary Cathepsin B levels in OSF and OSCC.
Method:
150 research participants in total were included in this study which were further divided into 3 groups, 50 in each group. Group 1 comprised 50 OSF patients, Group 2 comprised 50 OSCC patients and group 3 comprised 50 control group. Salivary Cathepsin B levels were analyzed in all 3 groups by using ELISA technique after saliva sample collection.
Results:
Cathepsin B salivary levels were found to be increased significantly in both OSF and OSCC patients in comparison to control group with significant higher < 0.001 p-value. Highest mean salivary Cathepsin B levels were found in OSF 9.50s ± 7.3, followed by OSCC 4.54 ± 5.9 and control group 0.45s ± 0.9 respectively.
Conclusion:
Cathepsin B salivary levels were observed to be increased significantly both in patients of OSF and OSCC. Therefore, Cathepsin B can be considered a useful and beneficial salivary biomarker for early detection of OSCC.
In Silico Analysis of Cloned Brown Planthopper Genes Unveiled OsJ_28113 as a Key Regulator in Triggering Resistance Response in Rice
Authors: Kaur Pavneet , Pankaj Rana , Kumar Kishor , Kaur Ramanjot , Neelam Kumari 
Published: August 2023

Abstract
Brown planthopper (BPH) is a highly destructive insect pests of rice, causing significant yield loss. Due to its constantly evolving nature, continuous analysis of BPH's protein domain-interacting partners is essential. In the present study, in silico approach was followed to predict 3-D structure of cloned BPH-resistant proteins (Bph6, Bph9, Bph14, Bph17, Bph18, Bph26, Bph29 and Bph32) using a comparative modeling approach and their interaction studies. The Interactome analysis revealed a key regulator, OsJ_28113, responsible for transducing extracellular signals into intracellular responses, potentially aiding in activating proteins that provide resistance against BPH. The proposed model provides insights into the structure and active sites of these proteins, offering opportunities to develop novel strategies for BPH control in rice plants. The molecular profile analysis revealed that BPH resistance genes containing the CC-NBS-LRR domain have varying length of amino acid chains ranging from 1082 for Bph30 to the longest (2024) for Bph6. Bph26 and Bph18 demonstrated high sequence similarity containing NB-ARC and LRR domains. The secondary structure prediction results anticipated that all the proteins, except Bph30, are cytoplasmic and soluble. The in silico findings support the notion that variability in resistance genes is a result of ongoing evolutionary interactions between plants and insect pests. Additionally, the study uncovered higher ligand binding affinities towards jasmonic acid compared to salicylic acid, paving the way for further research on receptor-ligand recognition and signaling mechanisms against rice planthoppers.
Development and quality assessment of the psychometric properties of the Self-Efficacy in Lifestyle Counselling scale (SELC 20+20) using Rasch analysis
Authors: Alenius Sara , Westergren Albert , Lindström Petra Nilsson , Nilsson Marie , Rask Marie , Behm Lina 
Published: August 2023

Abstract
Background
Globally as well as in Sweden, diseases that are caused by unhealthy lifestyle habits are the most common causes of death and disability. Despite guidelines that obligate all health care professionals to counsel patients about lifestyle, studies have shown that this is not prioritized within health care. One reason for this omission, among nurses, is a lack of confidence in knowledge and counselling skills. This study aimed to develop and provide a quality assessment of the psychometric properties of an instrument to measure self-efficacy in lifestyle counselling.
Methods
A measurement instrument, inspired by an existing American instrument following Bandura’s recommendations for the development of self-efficacy measures, was developed according to Swedish national guidelines for disease prevention. The instrument was revised after 18 kognitive interviews with nurses, student nurses and clinical experts and was administered to 310 nursing students at different education levels. The instrument was tested with Rasch model analysis with a focus on dimensionality, local dependency, targeting, reliability, response category functioning, Rasch model fit, and differential item functioning by age, gender, educational level and previous health care education.
Results
The development of the instrument resulted in 20 + 20 items, 20 about self-efficacy in knowledge and 20 about self-efficacy in the ability to counsel persons about their lifestyle. The analyses showed that knowledge and ability are two different, but related constructs and that ability is more demanding than knowledge. The findings indicate (considering dimensionality and local dependency) that all 20 items within the knowledge construct as well as the 20 items within the ability construct can be summed to obtain two separate but related total scores, where knowledge (reliability 0.91) is a prerequisite for ability (reliability 0.93). The items represented lower self-efficacy than reported by the respondents. The response categories functioned as expected, the Rasch model fit was acceptable, and there was no differential item functioning.
Conclusions
The SELC 20 + 20 was found to be easy to understand with an acceptable respondent burden, and the instrument showed good measurement properties. The instrument can be a useful tool in the professional education of health care personnel and clinically in health care.
Rising Tides: Analytic Modeling of Tidal Effects in Binary Neutron Star Mergers
Authors: O'Dell Alexander , Hamilton Maria C. Babiuc 
Published: August 2023

Abstract

The gravitational waves produced by binary neutron star mergers offer a unique window into matter behavior under extreme conditions.In this context, we model analytically the effect of matter on the gravitational waves from binary neutron star mergers. We start with a binary black hole system, leveraging the post-Newtonian formalism for the inspiral and the Backwards-one-Body model for the merger.We combine the two methods to generate a baseline waveform and we validate our results against numerical relativity simulations. Next, we integrate tidal effects in phase and amplitude to account for matter and spacetime interaction, by using the NRTidal model, and test its accuracy against numerical relativity predictions, for two equations of state, finding a mismatch around the merger. Subsequently, we lift the restriction on the coefficients to be independent of the tidal deformability, and recalibrate them using the numerical relativity predictions. We obtain better fits for phase and amplitude around the merger, and are able to extend the phase modeling beyond the merger.We implement our method in a new open-source Python code, steered by a Jupyter Notebook.Our research offers new perspectives on analytically modeling the effect of tides on the gravitational waves from binary neutron star mergers.
There exists a correlation between hemoglobin concentration and metabolic dysfunction
Authors: Zhao Linlin , Cui Man , Zhou Hui , Li Meng 
Published: August 2023

Abstract
Background
The prevalence of metabolic unhealthy has emerged as a significant concern within the public health domain on a global scale. The potential correlation between hemoglobin concentration and metabolic unhealthy remains uncertain. Consequently, we endeavoured to examine this relationship both at the initial assessment and during the subsequent 3-year follow-up period.
Methods
A total of 4178 participants were enrolled in a 3-year follow-up study. Each participant completed a questionnaire and underwent anthropometric measurements and laboratory tests. The association between hemoglobin levels and metabolic abnormalities was evaluated using one-way ANOVA and logistic regression models.
Results
In comparison to the metabolically healthy group, the metabolically unhealthy group exhibited elevated baseline age, SBP, DBP, BMI, ALT, ALB, SCR, UA, FBG, TC, TG, HB, and PWV, while HDL-C was decreased. These findings were statistically significant. The prevalence of abnormal metabolism progressively increased with higher baseline hemoglobin levels. At the end of the follow-up period, hemoglobin levels were significantly higher in the metabolically abnormal group than at baseline. Furthermore, there was a positive correlation between baseline hemoglobin concentration and the incidence of metabolic abnormalities.
Conclusions
Monitoring the concentration of hemoglobin serves as a cost-effective and easily accessible means of detecting the onset of metabolic illness at an early stage.
Synthesis, Anti-mycobacterial activity, Molecular Docking and ADME analysis of spiroquinoxaline-1,2,4-oxadiazoles via [3+2] cycloaddition reaction under ultrasound irradiation
Authors: Kanchrana Madhu , Krishna Gamidi Rama , Kumari Jyothi , Sri Dharmarajan , Basavoju Srinivas 
Published: August 2023

Abstract
A convenient ultrasound methodology was employed to attain spiroquinoxaline-1,2,4-oxadiazoles via[3+2] cycloaddition of quinoxalineSchiff bases and aryl nitrile oxides at room temperature. This approach evades standard heating and column chromatography while producing high yields and lesser reaction times. The target compounds 3a-p were well characterized and their in vitro anti-mycobacterial activity (anti-TB) was evaluated. Among the screened compounds 3i has displayed promising activity against Mycobacterium tuberculosis cell line H37Rv with MIC value 0.78 µg/mL. However, three compounds (3f, 3h and 3o) exhibited potent activity with MIC value 6.25 µg/mL. To further understand the binding interactions, the synthesized compounds were docked against the tuberculosisprotein 5OEQ using in silicomolecular docking. Moreover, the utmost active compounds were additionally partitioned for their cytotoxicity against RAW 264.7 cell line, which revealed that the compounds 3f, 3h, 3i and 3o were less harmful to humans. Furthermore, the synthesized compounds were tested for ADME qualities, and the results suggest that this series is useful to produce innovative and potent anti-tubercular medicines in the future.
Adaptability and stability of black bean genotypes with normal and early cycle
Authors: Ambrósio Moisés , Santos Raiane Mariani , Daher Rogério Figueiredo , Santana Josefa Grasiela Silva , Vidal Ana Kesia Faria , Nascimento Maxwel Rodrigues , Leite Cleudiane Lopes , Souza Alexandre Gomes , Freitasa Rafael Souza , Stida Wanessa Francesconi , Farias João Esdras Calaça 
Published: August 2023

Abstract
In the selection process of common bean genotypes with high yield performance associated with high adaptability and stability, accurate statistical procedures should be used, which promote greater precision in the comparison of means. In this context, the study aimed to select black bean genotypes of a normal and early cycle that simultaneously combine high yield, adaptability, and stability via non-parametric methods and mixed models. For this, two simultaneous trials were conducted in 2020 and 2021 in Campos dos Goytacazes - RJ. The first trial consisted of 14 black bean genotypes of the normal cycle; the second trial consisted of 14 black bean genotypes of the early cycle. The experimental design was a randomized block design with 14 normal-cycle and 14 early-cycle genotypes and three replications. After detecting the significant genotype-environment interaction (GxE), the adaptability and phenotypic stability of the genotypes were analyzed by the methods of the harmonic mean of the relative performance of genotypic values (HMRPGV), Annicchiarico (1992), Lin & Binns (1988), and stability index called WAASB (Weighted Average of Absolute Scores). The genotypes that gather adaptability and stability associated with high yield potential, sufficient for a recommendation for the state of Rio de Janeiro, are BRS Esteio, CNFP 19325 belonging to the normal group and BRS Campeiro, CNFP 17445, and CNFP 17466 belonging to the early group. The combined use of mixed model methodologies and non-parameter models enables a more accurate selection of the most promising genotypes.
Effect of PGPR and mixed cropping on mycorrhizal status, soil fertility, and date palm productivity under organic farming system
Authors: OU-ZINE Mohamed , SYMANCZIK Sarah , KINANY Said El , AZIZ Larbi , FAGROUD Mustapha , ABIDAR Ali , MÄDER Paul , ACHBANI El Hassan , HAGGOUD Abdellatif , HILALI Rania EL , ABDELLAOUI Mustapha , BOUAMRI Rachid 
Published: August 2023

Abstract

A field study was carried out for two years at an organic farm under arid climate in Morocco to investigate the effect of an integrated biofertilization approach on Arbuscular Mycorrhizal Fungal (AMF) abundance and infectivity, soil fertility, yield, and fruit quality of date palm. The biofertilization approach included three management practices namely application of compost, inoculation with a consortium of native PGPR strains originally isolated from date palms of Drâa-Tafilalet region (Pseudomonas koreensis, Serratia nematodiphila, S. marcescens, and Klebsiella sp.) and using mixed-cropping with sorghum. Accordingly, four treatments were established in this study: 1) mixed-cropping with sorghum, 2) PGPR inoculation, 3) sorghum + PGPR, and 4) control (without sorghum or PGPR). All treatments received compost as organic amendment. Results revealed that mixed-cropping with sorghum significantly increased AMF colonization intensity and spore density by more than 50% and 29%, respectively. Sorghum association also resulted in a significant increase in organic matter concentrations of up to 2.95% against 2.45% in monocropping soils. The integrated biofertilization approach resulted in the highest yield with an increase rate of 10.6% and 12.1% in the first and the second year, respectively compared to date palms receiving compost alone. Similarly, the mineral composition and quality characteristics of date fruits were significantly improved. The enhancement of soil fertility and date palm productivity under harsh environmental conditions represents a first step towards the adoption of sustainable practices in the region and in similar areas.
Bacteriophage and non-pathogenic vibrio to control diseases in black tiger shrimp (Penaeus monodon) aquaculture
Authors: Hossain Md. Mer Mosharraf , Tanni Lutfun Nahar , Rahman Md. Anisur , Farjana Nawshin , Moon Rubab Sharmeen , Tonni Nishat Zahan , Mekat Mahbuba Rahman , Mojumdar Shoumik , Prince Nimur Rahman , Rojoni Suraiya Alam , Smrity Ummay Rubayea , Sen Bipul Kumar , Saha Pobitra Kumar 
Published: August 2023

Abstract
The study aimed to address the recurring outbreaks of microbial diseases in black tiger shrimp (Penaeus monodon) aquaculture in Bangladesh by utilizing bacteriophages and non-pathogenic Vibrio. Bacteriophages were isolated from sewage water collected from a shrimp farm, hatchery, and the JUST campus. The infectivity of the bacteriophages against various Vibrio strains was evaluated to determine their bacteriolytic activity. Non-pathogenic Vibrio strains were obtained from suspected diseased isolates collected from the south-western region of Bangladesh through PCR testing. In laboratory tests, the bacteriophages successfully infected 91% of the tested Vibrio strains (19 out of 21 strains). In the experimental unit, shrimp treated with phage prophylaxis and phage treatment exhibited significant protection against Acute Hepatopancreatic Necrosis Disease (AHPND) and survived a deadly bacterial challenge. PCR amplification identified five non-pathogenic Vibrio strains from a total of 35 suspected diseased isolates. Field trials were conducted, applying cultured bacteriophages at a concentration of 1.5x106 PFU/ml and non-pathogenic Vibrio at 5x105 CFU/ml. These trials demonstrated improved protection against infections and did not result in severe mortality during the adaptive research phase. Morphological tests conducted on the cultured shrimp revealed a muscle gut ratio greater than 4:1 and no abnormal deformities in the appendages or overall body of the shrimp, indicating their overall health and well-being. Bacteriological tests conducted on the shrimp samples showed an 18% bacterial infection rate, primarily involving Vibrio cholerae, Vibrio parahaemolyticus, and some other bacteria. However, these infections did not result in a disease outbreak. PCR amplification conducted in the fish molecular biology lab at JUST yielded negative results for AHPND, White Spot Syndrome Virus (WSSV), and Enterocytozoon hepatopenaei (EHP). These results highlight the potential of using bacteriophages and non-pathogenic Vibrio as a sustainable approach to prevent and control microbial diseases in shrimp aquaculture. The study provides valuable insights into the development of alternative strategies to combat antibiotic resistance and support the growth of the shrimp industry in Bangladesh.