bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Testing of ASP Flooding Without Water Softening in the Marmul Field in Southern Oman
Authors: Al Farsi Samya , Bouwmeester Ron , Al Bulushi Abdullah , Karpan Volodimir , Al Mahruqi Dawood , Al Sulaimani Hanaa 
Published: March 2023

Abstract
Alkaline Surfactant Polymer (ASP) flooding has proven to be an effective method to recover remaining oil after a water flood through numerous laboratory and field tests. Yet, several operational complications limit the broad implementation of ASP technology. Source water requires softening to avoid injectivity issues due to scale formation when alkali is added to the solution. Even when softened water is used to prepare the injected ASP solution, scaling is often an issue in producing wells due to the mixing of injected ASP solution and harder reservoir brine in situ. Scale control through scale inhibitors has been reported to be successful in some cases.
Usually, sodium carbonate is used as an alkali in ASP, and carbonate scaling issues are most severe in such a case. However, even if another alkali is used, carbonate scale remains an issue because, at high pH, the bicarbonate present in almost any formation water will be converted to carbonate and subsequently precipitate with the divalent ions present in the formation brine or unsoftened ASP make-up water.
Monoethanolamine (MEA) has been used as an alkali in the ASP Phase 1A project in a sandstone reservoir in Southern Oman. The produced water reinjected in the field has a relatively low concentration of divalent ions. It was realized that further ASP implementation could be significantly simplified if softening of the produced water could be avoided.
Based on the results of extensive laboratory studies, it was proposed to conduct the scaling inhibitor injection and propagation field trial. The trial's objective is to evaluate the use of a suitable scale inhibitor with the MEA-based ASP formulation as an alternative to water softening under field conditions. This project was executed after completing ASP Phase 1A and lasted about two months. Injection and production results from the trial and implications for future ASP implementation are presented in the paper.
Ecological barriers mediate spatiotemporal shifts of bird communities at a continental scale
Authors: Marjakangas Emma-Liina , Bosco Laura , Versluijs Martijn , Xu Yanjie , Santangeli Andrea , Holopainen Sari , Mäkeläinen Sanna , Herrando Sergi , Keller Verena , Voříšek Petr , Brotons Lluís , Johnston Alison , Princé Karine , Willis Stephen , Aghababyan Karen , Ajder Vitalie , Balmer Dawn , Bino Taulant , Boyla Kerem Ali , Chodkiewicz Tomasz , Moral Juan Carlos del , Mazal Vlatka Dumbović , Ferrarini Alessandro , Godinho Carlos , Gustin Marco ,   Mikhail Kalyakin7, Knaus Peter , Kuzmenko Tatiana , Lindström Åke , Maxhuni Qenan , Molina Blas , Nagy Károly , Radišić Dimitrije  , Rajkov Saša , Rajković Draženko Z. , Raudonikis Liutauras , Sjeničić Jovica , Stoychev Stoycho , Szep Tibor , Teufelbauer Norbert , Ursul Silvia , Turnhout Chris van , Velevski Metodija , Vikstrøm Thomas , Wilk Tomasz , Voltzit Olga , Øien Ingar Jostein , Lehikoinen Aleksi 
Published: March 2023

Abstract

Species’ range shifts and local extinctions caused by climate change lead to community composition changes. At large spatial scales, ecological barriers, such as biome boundaries, coastlines, and elevation, can influence a community's ability to shift in response to climate change. Yet, ecological barriers are rarely considered in climate change studies, potentially hindering predictions of biodiversity shifts. We used data from two consecutive European breeding bird atlases to calculate the geographic distance and direction between communities in the 1980's and their compositional best match in the 2010’s and modeled their response to barriers. The ecological barriers affected both the distance and direction of bird community composition shifts, with coastlines and elevation having the strongest influence. Our results underscore the relevance of combining ecological barriers and community shift projections for identifying the forces hindering community adjustments under global change. Notably, due to (macro)ecological barriers, communities are not able to track their climatic niches, which may lead to drastic changes, and potential losses, in community compositions in the future.
Design a wireless network on chip (NoC) architecture for multi-core platforms with optimized topology
Authors: R POOVENDRAN 
Published: March 2023

Abstract
Forceful scaling of transistors permits the combination of many processors on a chip. Notwithstanding, on-chip interconnects conveying signals between various squares will be the bottleneck for framework execution and unwavering quality. To handle this issue, we built up an on-chip correspondence foundation dependent on a system-on-chip design and built up a crossbreed instrument to exchange information among IP centers by taking focal points of both wired and remote interchanges. By utilizing on-chip radio wires, one can give on-chip remote correspondence to exchange information crosswise over long separations and limit exchange idleness and vitality scattering appropriately. Remote system-on-chip engineering was structured and assessed, and the trial results demonstrated huge improvement in exchange idleness, organize throughput, and vitality scattering. In this paper, to continue the high-transfer speed and high-throughput prerequisites of rising applications, we propose the plan of a remote NoC (WiNoC) engineering joining vital multicast support. By coordinating multicast steering with system coding, the WiNoC can effectively deal with overwhelming multicast infusions. For applications running with a broadcast heavy Hammer store intelligence convention, the proposed multicast aware WiNoC accomplishes a normal 47% decrease in message inactivity contrasted and the XY-tree-based multicast-mindful work NoC. This system-level improvement converts into a 26% sparing in full- Framework vitality postpone item.
Multiomics integration of 22 immune-mediated monogenic diseases reveals an emergent axis of human immune health
Authors: Tsang John , Sparks Rachel , Rachmaninoff Nick 
Published: March 2023

Abstract

Monogenic diseases are often studied in isolation due to their rarity. Here we utilize multiomics to assess 22 monogenic immune-mediated conditions with age- and sex-matched healthy controls. Despite clearly detectable disease-specific and “pan-disease” signatures, individuals possess stable personal immune states over time. Temporally stable differences among subjects tend to dominate over differences attributable to disease conditions or medication use. Unsupervised principal variation analysis of personal immune states and machine learning classification distinguishing between healthy controls and patients converge to a metric of immune health (IHM). The IHM discriminates healthy from multiple polygenic autoimmune and inflammatory disease states in independent cohorts, marks healthy aging, and is a pre-vaccination predictor of antibody responses to influenza vaccination in the elderly. We identified easy-to-measure circulating protein biomarker surrogates of the IHM that capture immune health variations beyond age. Our work provides a conceptual framework and biomarkers for defining and measuring human immune health.
Creation and Validation of a Sports Vocational Guidance Protocol *#
Authors: Bispo Michael Douglas Celestino , Santos Darlan Tavares , Santos Marcos Antonio Almeida , Nodari-Júnior Rudy José , Gomes Antonio Carlos , Dantas Estélio Henrique Martin 
Published: March 2023

Abstract
Scientific studies that explore guidelines for sports vocation are scarce. The objective of this study is to develop and validate (through verification of content and face validity, reliability and objectivity) a protocol to guide sports vocation. The protocol established to accomplish vocational guidance is the result of the variables attributed to dermatoglyphic analysis and anthropometric measurements. Validity was established based on the development of a Table of Epigenetic Characteristics for Sports (QCEE), subsequently validated using the computerized Delphi method. After validation, reliability and objectivity were evaluated using an intra and interrater correlation, respectively. To that end, an experimental sample group of 105 children; 55 females and 50 males, between the ages of 8 and 17 (age x̄=12.0 ±2.30 years) was used. Protocol validation obtained significant results, as follows: Validity (100% agreement in the 3rd round; Reliability (rmean=1.00; p<0.001 and α ≥ 0.99) and Objectivity (rmean= 0.99; p<0.001 and α ≥ 0.99). This result provides the scientific community with a reliable sports vocational guidance protocol for young people and contributes to the aims of sustainable development until 2030 and worldwide post-pandemic recovery.
Big Advocacy, Little Recognition: The Hidden Work of Black Patients in Precision Medicine
Authors: Gerido Lynette Hammond , Resnicow Kenneth , Stoffel Elena , Tomlin Tiah , Cook-Deegan Robert , Cline Melissa , Coffin Amy , Holdren Jill , Majumder Mary Anderlik , He Zhe 
Published: March 2023

Abstract

Public health genomics prioritizes effective and ethical translation of genomic science into population health precision medicine. With the rapid development of cost-effective, next-generation genome sequencing, calls are growing for greater inclusion of Black people in genomic research, policy, and practice. Genetic testing is often the first step in precision medicine. This study explores racial differences in patient concerns about genetic testing for hereditary breast cancer. Employing a community-based participatory mixed methods research design, we developed a semi-structured survey that was shared broadly. There were 81 survey respondents, of which, forty-nine (60%) self-identified as Black, twenty-six (32%) indicated they had a history of a breast cancer diagnosis, or had received BRCA genetic testing. Black participants who expressed concerns about genetic testing were fairly equally distributed between concerns that could be addressed with genetic counseling (24%) and concerns about the subsequent use of their genetic data (27%). The concerns expressed by the participants in our study underscore a need for transparent disclosures and assurances regarding the use and handling of genetic data. These findings should be viewed in context with patient-led efforts to overcome systemic inequities in cancer care, as Black cancer patients have joined forces with advocates and researchers to develop protective health data initiatives and to improve their representation in genomic datasets. Future research should prioritize the information needs and concerns of Black cancer patients. Interventions should be developed to support their hidden work as a means to reduce barriers and improve representation in precision medicine.
Viscosity of graphene in lubricating oil, ethylene glycol and glycerol
Authors: Bao Jianhong , Heyd Rodolphe , Régnier Gilles , Ammar Amine , Peixinho Jorge 
Published: March 2023

Abstract
This paper reports the results of an experimental investigation of graphene particle suspensions in lubricating oil, ethylene glycol and glycerol-based fluids. Graphene of different specific surface area show variation in the viscosity depending on the shear rate and the temperature. The lubricating effect, e.g. reduction of the viscosity compared to the base fluid, is observed for the low concentration (below 0.4 wt.%) in lubricating oil and glycerol. In the range of parameters studied (e.g. concentration below 1 wt.% and temperature up to 80 °C), the activation energy slightly decreases. The enhancement of viscosity with graphene volume fraction is stronger for ethylene glycol.
Examining the nexus between medical education and complexity: a systematic review to inform practice and research.
Authors: Ogden Kathryn , Kilpatrick Sue , Elmer Shandell 
Published: March 2023

Abstract
Background: Medical education is a multifarious endeavour integrating a range of pedagogies and philosophies. Complexity as a science or theory (‘complexity’) signals a move away from a reductionist paradigm to one which appreciates that interactions in multi-component systems, such as healthcare systems, can result in adaptive and emergent outcomes. This examination of the nexus between medical education and complexity theory aims to discover ways that complexity theory can inform medical education and medical education research.
Methods: A meta-narrative systematic literature review was conducted to examine the nexus between medical education and complexity; 5 databases were searched using relevant terms. Papers were included if they engaged fully with complexity as a science or theory and were significantly focused on medical education. All types of papers were included, including conceptual papers (e.g. opinion and theoretical discussions), case studies, program evaluations and empirical research. A qualitative synthesis was undertaken to identify narratives and create a meta-narrative of the use of complexity in medical education.
Results: Eighty-three papers were included; the majority were conceptual papers. An overarching narrative established the context and theoretical underpinnings of complexity as a relevant theory for medical education. Temporal observations were noted regarding the entry of complexity into medical education. Complexity was relied upon as theoretical framework for empirical studies covering a variety of elements within medical education including learning theories, curriculum and program development, competency and capability, professionalism and leadership, medical education and program evaluation, faculty development, assessment, learning environments, learning for systems through interprofessional education and simulation training, and learning about systems.
Discussion: There is a call for greater use of theory by medical educators. Complexity was found to be a useful theory, albeit by a limited number of authors, and is increasingly being used by medical educators and medical education researchers. This review has further conceptualized how complexity is being used to support medical education and medical education research.
Conclusion: This examination of the literature can assist those involved in medical education and medical education research in understanding how complexity can be useful in their own practice.
Minimal mechanistic component of HbYX-dependent proteasome activation
Authors: Smith David , Chuah Janelle , Thibaudeau Tiffany , Rexroad Matthew 
Published: March 2023

Abstract
The implication of reduced proteasomal function in neurodegenerative diseases combined with numerous studies showing the protective effects of increasing proteasome activity in animal models justify the need to understand how the proteasome is activated for protein degradation. The C-terminal HbYX motif is present on many proteasome binding proteins and functions to tether activators to the 20S core particle. Peptides with a HbYX motif can also autonomously activate 20S gate-opening to allow protein degradation, but the underlying allosteric molecular mechanism is not clear. We designed a HbYX-like dipeptide mimetic that represents only the fundamental components of the HbYX motif to allow rigorous elucidation of the underlying molecular mechanisms of HbYX induced 20S gate-opening in the archaeal and mamalian proteasome. By generating several high-resolution cryo-EM structures (e.g. 1.9Å) we identified multiple proteasome α subunit residues involved in HbYX-dependent activation and the conformational changes involved in gate-opening. In addition, we generated mutants probing these structural findings and identified specific point mutations that strongly activate the proteasome by partially mimicking a HbYX-bound state. These structures resolve 3 novel mechanistic features that are critical for allosteric α subunit conformational changes that ultimately trigger gate-opening: 1) rearrangement of the loop adjacent to K66, 2) inter- and intra- α subunit conformational changes and 3) a pair of IT residues on the α N-terminus in the 20S channel that alternate binding sites to stabilize the open and closed states. All gate-opening mechanisms appear to converge on this “IT switch”. When stimulated by the mimetic, the human 20S can degrade unfolded proteins such as tau, and prevent proteasomal inhibition by toxic soluble oligomers. Collectively, the results presented here provide a mechanistic model of HbYX-dependent 20S gate-opening and offer proof of concept for the robust potential of HbYX-like small molecules to stimulate proteasome function, which could be useful to treat neurodegenerative diseases.
Green coffee powder: effect on growth performance, biochemical blood indices, and intestine morphology in broiler chickens
Authors: Hosseini-Vashan Seyyed Javad , Manochehri Davod , Afzali Nazar , Yonesi Hossein Naeimipour 
Published: March 2023

Abstract
This research was done to investigate the effect of different levels of green coffee powder(GCP) on growth performance, immune response, biochemical blood indices, and intestinal morphology in broiler chickens. A total of 300 one-day-old male Ross 308 broilers were used in a completely randomized design with six treatments, 5 replicates, and 10 chicks each. The dietary treatment included six levels of 0, 0.3, 0.6, 0.9, 1.2, and 1.5% of coffee powder. Compared to control, GCP increased the body weight and feed intake in broiler by 0.3% and 1.5%, respectively(P<0.05). A lower feed conversion ratio was observed in broilers fed with 1.5% GCP compared to the control (P<0.05). Adding 0.9% of GCP to the broiler diet increased the relative weight of carcass components, including breast, thigh, and bursa of fabricius, compared to control. The GCP at all levels reduced the relative weight of abdominal fat compared to control(P<0.05). The coffee powder had no effect on immunoglobulin M index against SRBC; however, total antibody index against SRBC increased in chickens fed GCP compared to control(P<0.05). Coffee powder decreased blood cholesterol, LDL, and triglyceride concentration, and increased blood HDL, albumin, glucose, and protein concentration compared to control(P <0.05). The villi height and depth of crypt increased in broiler fed 1.2% GCP compared to control(P<0.05). It is concluded that the use of green coffee powder at the level of 0.3% in the broiler diet may improve growth performance and some biochemical indices; however, the levels of 1.2 and 1.5% GCP may improve the intestinal morphology and immune response of broilers.
ESG Investing and the Financial Performance: A Panel Data Analysis of Developed REIT Markets
Authors: Erol Isil , Unal Umut , Coskun Yener 
Published: March 2023

Abstract
This study investigates the empirical link between the social and financial performance of the Real Estate Investment Trusts (REITs) by utilizing the PVAR-Granger causality model and a fixed-effects panel data model with a rich dataset comprising 234 ESG-rated REITs across five developed economies from 2003 to 2019. The results suggest that investors pay attention to individual E/S/G metrics and price each component of ESG investing differently, with E-investing and S-investing practices being the significant financial performance factors of REITs. This study is the first attempt to test the social impact and risk mitigation hypotheses of the stakeholder theory of the corporation and the neoclassic trade-off argument to explore the association between corporate social responsibility and the market valuation of REITs. The full sample results strongly support the trade-off hypothesis, indicating that REITs’ environmental policies involve high financial costs that may drain off capital and lead to decreasing market returns. On the contrary, investors have attached a higher value to S-investing performance, especially in the post-GFC period from 2011 to 2019. A positive premium for S-investing supports the stakeholder theory as the social impact could be monetarized into a higher return and a lower systematic risk and give rise to a competitive advantage.
JEL Codes: G11; G15; G32; M14
Molecular events leading to CX-5461-induced DNA damage response in vascular smooth muscle cells
Authors: Liu Tengfei , Pan Guopin , Zhang Jing , Wang Jianli , Chen Ye , Wang Xiaoyun , Cui Xiaopei , Guo Xiaosun , Jiang Fan 
Published: March 2023

Abstract
Background
Our previous studies have shown that the novel selective RNA polymerase I inhibitor CX-5461 suppresses proliferation of vascular smooth muscle cells, mainly via induction of activations of ataxia telangiectasia mutated (ATM)/ATM and Rad3-related (ATR) and p53. Currently, there is no information about what kinds of molecular events mediate such a DNA damage response (DDR) in vascular cells.
Methods
Primary aortic smooth muscle cells were isolated from normal adult Sprague Dawley rats and cultured in vitro. Immunofluorescence assays were conducted to assess the activation of various DDR pathways.
Results
We demonstrated that CX-5461-induced DDR was not associated with activations of the nucleotide excision repair, DNA mismatch repair, or the non-homologous end joining pathways, while the homologous recombination pathway was activated. However, the alkaline comet assay did not show massive DNA double strand breaks in CX-5461-treated cells. Instead, CX-5461-triggered DDR appeared to be related to induction of DNA replication stress, which was not attributable to increased formation of G-quadruplex or R-loop structures, but might be explained by increased replication-transcription conflict. CX-5461-induced DDR was not exclusively confined to rDNA within the nucleolar compartment; the extra-nucleolar DDR might represent a distinct secondary response related to the downregulated Rad51 expression in CX-5461-treated cells.
Conclusions
We suggest that DNA replication stress may be the primary molecular event leading to downstream ATM/ATR and p53 activations in CX-5461-treated vascular smooth muscle cells. Our results provide further insights into the molecular mechanisms underlying the reported beneficial effects of CX-5461 in the cardiovascular system.