bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left atrial appendage thrombus and PFO in a patient diagnosed TIA with sinus rhythm: a case report
Authors: Yin Li-li , Li Yan-hua , Xie Wen-li , Geng Zhao-hong , Zhang Li-jiao , Liu Zhen-zhu , Mei Jia-jie 
Published: April 2023

Abstract
Background The detachment of the left atrial appendage(LAA) thrombus is the major cause of cardioembolic stroke(CES)/cardioembolic transient ischemic attack(CETIA). A LAA thrombus is very infrequently detected in the presence of sinus rhythm. Patent foramen ovale(PFO) is another common reason for CES/CETIA, especially among young and middle-aged people.Case Presentation We reported a case of a 46-year-old man who presented with TIAs and was subsequently found with PFO and LAA thrombus despite being in sinus rhythm and basically normal structure and function. Anticoagulant treatment was effective, and there was no recurrence of TIA or stroke.Conclusion LAA thrombus could occur in sinus rhythm and normal structure and function. The PFO may be an innocent bystander in the patient suspected of CES/CETIA. Percutaneous PFO closure should be cautiously chosen.
Application of Accounting Software and Enterprise Productivity——Evidence from Unlisted Companies
Authors: Jiang Allen 
Published: April 2023

Abstract
The existing research on the economic consequences of accounting informatization mainly focuses on enterprise resource planning (ERP) systems, but in reality, most companies are still using relatively simple accounting software. This paper empirically analyzes the application of accounting software in unlisted companies and its impact on enterprise productivity for the first time with a large sample of tax return information. We found that 75% of unlisted companies use accounting software of varied functions, but only 6% of them use ERP systems. With other factors unchanged, it is found that the productivity of enterprises using accounting software is significantly higher than that of enterprises not using accounting software, and the performance of accounting software is significantly positively correlated with productivity. This correlation is reinforced by the ability of enterprises to utilize accounting information and their growth opportunities. This paper adopts methods such as the Granger causality test and instrumental variable regression to alleviate endogeneity problems. This paper will contribute to a more comprehensive understanding of the economic consequences of accounting information systems and provide an important decision-making reference for promoting high-quality economic development.
Develop a Clinical Scoring Model Based on Noninvasive Bioindicators to Predict Fibrosis Risk in Nonobese Nonalcoholic Fatty Liver Patients
Authors: Jin Wenyi , Wang Zhiyi , Weng Jie , Pan Xianjuan , Zhou Peisen 
Published: April 2023

AbstractBACKGROUND:The presence of fibrosis is the main cause of the progression of nonalcoholic fatty liver disease (NAFLD). Our study aims to develop a simple clinical scoring system and nomogram for evaluating fibrosis in non-obese NAFLD patients.METHODS:This retrospective study included 99 non-obese NAFLD patients who underwent liver biopsy in China. The clinical scoring system and nomogram were used to predict the disease progression of NAFLD.RESULTS:Of the 99 non-obese patients with NAFLD, 41 (41.1%) were fibrosis. On multivariate logistic regression analysis, age, alanine aminotransferase(AST), platelet(PLT) and red blood cell (RBC) showed significant association with fibrosis (all P＜0.05). The area under curves (AUC) of the prediction model of fibrosis for non-obese patients established by the above four variables was 0.94 (95% confidence interval (CI):0.89-0.98). Moreover, the AUC of the further simplified clinical scoring model was 0.92 (95%CI 0.86-0.97). High risk group with score greater than or equal to 5, and low risk group with score less than or equal to 2. The nomogram had a good effect in evaluating the risk of fibrosis in non-obese NAFLD patients.CONCLUSION:A simple, easily calculated and non-invasive clinical score can reliably assess the presence of fibrosis in non-obese NAFLD patients. This scoring model complements the deficiency of the prediction system for disease progression in non-obese NAFLD patients, and brings good news for early identification and intervention of these patients.
High levels of Tfh/B-cell gene expression suggests poor prognosis in systemic chronic active Epstein-Barr virus disease
Authors: Miyoshi Hiroaki , Kawamoto Keisuke , Sato Kensaku , Takeuchi Mai , Nakashima kazutaka , Mori Kyohei , Miyawaki Kohta , Kato Koji , Kohno Kei , Furuta Takuya , Yamada Kyohei , Moritsubo Mayuko , Kimura Hiroshi , Ohshima Koichi 
Published: April 2023

Abstract
Systemic chronic active Epstein-Barr virus (CAEBV) disease is presumed to be caused by abnormal immunity toward EBV; however, its biological mechanism remains unknown. We investigated invasive immune-cell gene and EBV gene expressions in systemic CAEBV disease by comparing EBV-positive T-/NK-cell lymphomas (extranodal NK-/T-cell lymphoma [ENKTL] and EBV-positive nodal T- and NK-cell lymphoma [EBV-N-TNKL]). Gene expression profiling revealed a correlation between the expression levels of follicular helper T (Tfh)-cell and B-cell genes in systemic CAEBV disease. When we divided the patients into two groups according to the number of B-cells by immunohistochemistry, the B-cell high-count group showed a poorer prognosis than the low-count group. Additionally, the high-count group had higher EBV gene levels and EBV-positive B-cell counts than the low-count group. These results suggest that the clinical symptoms may be explained by the expansion of EBV-positive B-cells, resulting in a poor prognosis. Differential gene expression analysis revealed that systemic CAEBV disease exhibited more diverse gene expression levels than ENKTL and EBV-N-TNKL. The most significant variable genes were identified as novel distinguishing markers for systemic CAEBV disease. In conclusion, Tfh-cell and B-cell gene expression and diverse gene expression levels may correlate with unique clinical symptoms and prognosis in systemic CAEBV disease.
Speech-based Detection of Multi-class Alzheimer Disease Classification Using Machine Learning
Authors: Tripathi Tripti , Kumar Rakesh 
Published: April 2023

Abstract
Alzheimer's disease is a severe neurological condition that affects numerous people globally with detrimental consequences. Detecting AD early is crucial for prompt treatment and effective management. This study presents a novel approach for classifying six different types of cognitive impairment using speech-based analysis, including probable AD, possible AD, MCI, memory impairments, vascular dementia, and control. The method employs speech data from DementiaBank’s Pitt Corpus, which is pre-processed to extract pertinent acoustic features. The characteristics are subsequently employed to educate five machine learning algorithms, namely KNN, DT, SVM, XGBoost, and RF. The effectiveness of every algorithm is assessed through a 10-fold cross-validation. According to the research findings, the suggested method that is based on speech obtains a total accuracy of 75.59% concerning the six-class categorization issue The proposed approach can be developed into a non-invasive, cost-effective, and accessible diagnostic tool for the early detection and management of cognitive impairment.
Effect of initial crack length, cross-head speed, and quenching on the fracture toughness of HDPE with and without UV stabilizers
Authors: Koriem A. , Singer R. , Ollick A. M. , Elhadary M. 
Published: April 2023

Abstract
Fracture toughness is the ability of the material to resist crack growth. The effect of cross-head speed, initial crack length, and quenching on the fracture toughness of high-density polyethylene (HDPE) is investigated in this research, the results show that the fracture toughness of both stabilized and non-stabilized samples is influenced by the cross-head speed and crack length. The effect of overheating followed by rapid cooling (quenching) is investigated for three different cooling temperatures. It is apparent that the quenching process highly affects the ductility of the polymer, where the material became very brittle.
In-depth analysis benefital effect of probiotics and fatty acids in anesis of depression
Authors: Gao Han , He Chengwei , Xin Shuzi , Hua Rongxuan , Du Yixuan , Wang Boya , Gong Fengrong , Yu Xinyi , Pan Luming , Gao Lei , Xu Jingdong 
Published: April 2023

Abstract
Depression is the most prevalent presenting psychiatric symptom among individuals of all ages and backgrounds, affecting approximately 300 million people worldwide. Therefore, it deserves a great deal of attention when it comes to management. An increasing body of evidence reveals that probiotics and fatty acids can improve with depression. However, the viewpoint claims that there is no effect on depression. Network meta-analyses of existing datasets provide for the estimation of comparative efficacy, the summation and interpretation of the wider context of the evidence base, and the understanding of the relative merits of different interventions. As a reason, the objective of this study was to undertake a meta-analysis to explore current evidence for probiotic or fatty acid depression therapy in order to establish a feasible option for depression patients. Data for probiotics were retrieved from 7 RCT studies (n = 394) and fatty acids from 24 RCT studies (n = 1876). The findings indicated that intervention outperforms control.
Design and validation of a questionnaire to measure the experiences of health workers (QEx-W) with a person-centered health care model
Authors: Rodríguez Martha Lucia Cárdenas , Cantor-Cruz Francy , Gutiérrez Ana María Castillo , Martínez Adriana Acosta , Martin José Raúl Gordillo , Gerometta Sandra Figueroa , Correa Amely Marieth Vargas , Gonzalez Nancy Yomayusa 
Published: April 2023

Abstract
Background Person-centered care seeks to empower patients and their families to participate in health care decisions. This model of care, aimed at better health outcomes and patient experience, is based on a set of determinants that affect the roles of health care providers.1–5 In addition to having an impact on performance and motivation, these determinants affect providers’ result in physical, emotional and psychological experiences with the patient and the health system. The objective of this study was to design and psychometrically validate a questionnaire to evaluate these experiences and describe the impact on health care providers.Method A survey with 23 questions and five domains was designed. It was emailed to health professionals at four institutions. The psychometric properties of construct validity were determined with factor analysis, discriminant validity with the Fornell and Lacker criteria and convergent validity with Spearman's correlation. Reliability was evaluated with the Cronbach coefficient.Results A total of 536 responses were analyzed. Three models were estimated, and the best goodness of fit was found in the 5-factor model. In the convergent validity, a rho of 0.54 (p = 0.000) was obtained, indicating a moderate correlation between the scales, and in the discriminant, AVE values greater than 0.05 were found, but none greater than the correlations between them. The alpha coefficient was 0.95 (p = 0.00), indicating high internal consistency.Conclusion The QEx-W, composed of five factors, shows high reliability and psychometric validity, so it can be used to measure the experience of Spanish-speaking workers in the health care environment.
WITHDRAWN: Beyond Westernised Curriculum: A Call to Embrace Traditional and Indigenous Design Practices in TVET Graphic Design Education in Ghana
Authors: Ofosu-Asare Yaw 
Published: April 2023

Abstract

This study examined the role of traditional and Indigenous design practices in technical and vocational education and training (TVET) Graphic Design education in Ghana. A survey was conducted to determine the extent to which these practices were being used in teaching and learning and the implications of their use for curriculum and teaching practices. The results demonstrate that while there is a willingness among teachers to engage traditional and Indigenous design practices in their teaching, there are also significant barriers to their implementation. The study highlights the need for more research on the engagement of these practices in TVET Graphic Design education in Ghana and the broader implications for design education in Africa. The significance of this study lies in its contribution to the growing body of research on the use of traditional and Indigenous design practices in design education, providing important insights into the barriers and opportunities for their use. This paper also provides recommendations for practice and policy that can inform the development of more effective and relevant design education in Ghana and Africa at large.
Secure and efficient online data sharing scheme using broadcast encryption with personalised message system
Authors: Yadav Snehlata , Tiwari Namita 
Published: April 2023

Abstract
In the healthcare industry, online data sharing has become increasingly important, but it also raises significant security concerns. To address these concerns, we propose a secure and efficient online data sharing scheme that uses a cryptographic primitive called broadcast encryption with personalised message system. This notion is applicable to many realistic broadcast services that supports IoT and cloud technology. Specifically, in our system, the data owner creates personalized data for each legitimate user in a group and then transmits a common encrypted data for the entire group in a way that completely hides the subscribed user set from outsiders. Only authorized users can recover personalised data, while all authorized consumers can decrypt the common data. Proposed scheme employs shamir secret sharing scheme to fairly distribute and reconstruct secret among various set up authority to prevent the insider attack from malicious setup authority.We highlight the security consideration in such a scenario and capture the security requirements in the security model. Subsequently, we present a concrete scheme, which is proven CPA secure under the decisional bilinear Diffie-Hellman exponent assumption. In addition, it uses asymmetric pairings whereas rest of the schemes used symmetric pairings, which in turn leads to the smaller and constant compact size ciphertext, constant decryption keys, reduced channel requirement, prevent fault attacks on symmetric bilinear map, and, enhanced performance.
Flow Of An Incompressible MHD Third Grade Fluid In An Inclined Cylindrical Pipe And Entropy Generation
Authors: Obi Boniface Inalu , Okorie Stella Ijeoma 
Published: April 2023

Abstract
In this study, flow of an incompressible MHD third grade fluid in an inclined cylindrical pipe and entropy generation are considered. The nonlinear momentum and energy equations for the flow presented. Regular perturbation technique employed for the solutions. The effects of some thermo-physical parameters examined. Results show that increase in the third grade parameter and the Grashof number increases both the velocity of the fluid flow and the temperature of cylindrical wall, while increase in the magnetic field parameter reduces the flow velocity. Results further show that in the third grade parameter and the Brinkman number indicates increase in temperature which enhances entropy generation number. The magnetic field parameter suppresses the temperature of the system thereby reduces entropy generation number.
Evolutionary paths that link orthogonal pairs of binding proteins
Authors: Avizemer Ziv , Martí‐Gómez Carlos , Hoch Shlomo Yakir , McCandlish David M. , Fleishman Sarel J. 
Published: April 2023

Abstract

Some protein binding pairs exhibit extreme specificities that functionally insulate them from homologs. Such pairs evolve mostly by accumulating single-point mutations, and mutants are selected if their affinity exceeds the threshold required for function1–4. Thus, homologous and high-specificity binding pairs bring to light an evolutionary conundrum: how does a new specificity evolve while maintaining the required affinity in each intermediate5,6? Until now, a fully functional single-mutation path that connects two orthogonal pairs has only been described where the pairs were mutationally close enabling experimental enumeration of all intermediates2. We present an atomistic and graph-theoretical framework for discovering low molecular strain single-mutation paths that connect two extant pairs and apply it to two orthogonal bacterial colicin endonuclease-immunity pairs separated by 17 interface mutations7. We were not able to find a strain-free and functional path in the sequence space defined by the two extant pairs. By including mutations that bridge amino acids that cannot be exchanged through single-nucleotide mutations, we found a strain-free 19-mutation trajectory that is completely functionalin vivo. Despite the long mutational trajectory, the specificity switch is remarkably abrupt, resulting from only one radical mutation on each partner. Each of the critical specificity-switch mutations increases fitness, demonstrating that functional divergence could be driven by positive Darwinian selection. These results reveal how even radical functional changes in an epistatic fitness landscape may evolve.
A Quasi-Spherical Net Power Fusion Reactor Based on High Temperature Superconducting Magnets
Authors: Rogers Joel G. , Egly Andrew A. , Wessel Frank J. 
Published: April 2023

Abstract
Particle in Cell (PIC) simulation has been used to design a quasi-spherical, net power, deuterium fueled, fusion reactor incorporating high temperature superconducting (HTS) magnets. Using the principles of Magneto-Electrostatic Trap design of Yushmanov(1980) the reactor is predicted to have power-balance Q = 7, improving on the classic Polywell design by incorporating HTS magnets and a high-current deuteron ion beam. With these improvements, a hexahedral reactor of only 4m diameter is predicted to produce 100 megawatts of net power, in a design that is suitable for practical commercial fusion power production.
Exploring Compersion: A Study on Polish Consensually Non-Monogamous Individuals and Adaptation of the COMPERSe Questionnaire
Authors: Buczel Klara A. , Szyszka Paulina D. , Mara Izu 
Published: April 2023

Abstract

Compersion is a positive emotion experienced in relation to one’s partner’s relationship(s) with other partner(s). Experiencing it is highly desired in communities practicing consensual non-monogamy (CNM), especially polyamory. This article presents the results of a study on compersion on Polish CNM individuals. The main goal of the study was to adapt to the Polish speaking population the COMPERSe (Classifying Our Metamour/Partner Emotional Response Scale; Flicker et al., 2021), the first standardized quantitative scale designed to measure compersion. The analyzes were performed on data obtained from 211 individuals in CNM relationships and on comparative group of 169 people in monogamous relationships. The results of the factor analyzes suggested that the 3-factor model of the original COMPERSe version did not fit well, leading to further revisions that resulted in a 7-item, 2-factor solution with excellent fit, excellent internal consistency, strong divergent and convergent validity, and excellent test-retest stability. The CNM individuals were found to have higher scores on compersion and cognitive empathy and were also less jealous than the monogamous participants. Furthermore, polyamorous individuals experienced more compersion and less aversion to partner’s autonomy than people in open relationships. It was also revealed that compersion indirectly predicted relationship satisfaction by decreasing jealousy and that compersion was, in turn, predicted by cognitive empathy. However, when polyamorous and open relationships were analyzed separately, compersion predicted relationship satisfaction directly, but only in polyamorous relationships; meanwhile, in open relationships, satisfaction was directly predicted by cognitive empathy.
Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis
Authors: Derby Sarah , Dutton Louise , Strathdee karen , Stevenson Katrina , Clough Emily , Koessinger Anna , Yu Wenxi , Tian Yuling , Gilmour Lesley , McGhee Ewan , McGarrity-Cottrell Connor , Dibekeme Aurelie anderlinden , Collis Spencer , Rominiyi Ola , Soares Leandro Lembruber , Peter  , Solecki Gergely , Winkler Frank , Carlin Leo , Inman Gareth , Chalmers Anthony , Norman Jim , Carruthers Ross , Birch Joanna 
Published: April 2023

Abstract
Background
Glioblastomas (GBM) have highly infiltrative growth patterns that contribute to recurrence and poor survival. Despite infiltration being a critical therapeutic target, no clinically useful therapies exist which counter GBM invasion. Here, we report that inhibition of Ataxia telangiectasia and Rad 3 related kinase (ATR) reduces invasion of GBM cells through dysregulation of cytoskeletal networks and subsequent integrin trafficking.
Methods
GBM motility and invasion was assessed both in vitro and in vivo in response to ATR inhibition (ATRi) and ATR over-expression using timelapse microscopy, two orthotopic GBM models and intravital imaging. Disruption to cytoskeleton networks and endocytic processing were investigated via high throughput, super resolution imaging and intravital imaging.
Results
High ATR expression was associated with significantly poorer survival in clinical datasets whilst GBM tumour specimens revealed higher ATR expression at infiltrative margins. ATRi opposed invasion of GBM cells due cytoskeletal dysregulation impacting integrin internalisation.
Conclusion
We demonstrate a novel role for ATR in determining invasion in GBM cells, and propose that pharmacological targeting of ATR could have far reaching clinical benefits.
Targeting of SOS1: from SOS1 Activators to Proteolysis Targeting Chimeras
Authors: Hamilton Gerhard , Stickler Sandra , Rath Barbara 
Published: April 2023

Abstract:
The most frequent mutated oncogene KRAS in lung cancer is targeted by KRAS G12C-directed
drugs, such as Sotorasib and Adagrasib. Still, other alleles frequently expressed in pancreatic and colon cancer
may be attacked indirectly by hitting the guanine nucleotide exchange factor (GEF) SOS1 that loads and activates
KRAS. The first modulators of SOS1 were found to act as agonists and defined a hydrophobic pocket at
the catalytic site. High throughput screenings resulted in the detection of SOS1 inhibitors Bay-293 and BI-3406
comprising amino quinazoline scaffolds optimized for binding to the pocket by various substituents. The first
inhibitor, BI-1701963, is in clinical studies alone or in combination with a KRAS inhibitor, a MAPK inhibitor
or chemotherapeutics. An optimized agonist, VUBI-1, shows activity against tumor cells by destructive overactivation
of cellular signaling. This agonist was used to formulate a proteolysis targeting chimera (PROTAC),
that labels SOS1 for degradation by proteasomal degradation through a linked VHL E3 ligase ligand. This
PROTAC exhibited the highest SOS1-directed activity due to target destruction, recycling and removal of
SOS1 as a scaffolding protein. Although other first PROTACs have entered clinical trials, each conjugate must
be meticulously adapted as an efficient clinical drug.