bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subtractive colour mixing with bile pigments creates the rich wing palette of Graphium weiskei butterflies
Authors: Stavenga Doekele G. 
Published: May 2023

ABSTRACT
The wings of the purple spotted swallowtail Graphium weiskei are marked by an unusual bright colour pattern. Spectrophotometry on G. weiskei wings demonstrated the presence of a pigment with an absorption spectrum (peak wavelength λmax=676 nm) similar to that of the bile pigment sarpedobilin in the wings of the congeneric Graphium sarpedon (λmax=672 nm). Sarpedobilin alone causes cyan–blue wing areas, but the green-coloured areas of G. sarpedon wings result from subtractive colour mixing with the carotenoid lutein. Reflectance spectra of the blue-coloured areas of G. weiskei wings indicate that sarpedobilin is mixed with the short-wavelength-absorbing papiliochrome II. An enigmatic pigment, tentatively called weiskeipigment (λmax=580 nm), enhances the saturation of the blue colour. Weiskeipigment causes a purple colour in areas where the sarpedobilin concentration is low. The wings of the related papilionid Papilio phorcas contain the bile pigment pharcobilin (λmax=604 nm), as well as another sarpedobilin (λmax=663 nm). The cyan to greenish wings of P. phorcas are due to phorcabilin and sarpedobilin mixed with papiliochrome II. A survey of known subspecies of G. weiskei as well as of congeneric Graphium species of the ‘weiskei’ group shows various degrees of subtractive colour mixing of bilins and short-wavelength absorbers (carotenoids and/or papiliochromes) in their wings. This study illuminates the underestimated role of bile pigments in butterfly wing colouration.
Phylogeny and evolution of erythrocytes in mammals
Authors: Udroiu Ion 
Published: May 2023

ABSTRACT
In the past century, several authors have investigated the allometry of haematological parameters in mammals. As haematocrit and haemoglobin (Hb) concentration are almost constant within the Mammalia (although with notable exceptions), differences in other haematological parameters are mainly reducible to red blood cell size (mean corpuscular volume, MCV). Past studies testing for correlation between MCV and body mass have given contradictory results. Using phylogenetically informed regressions, here I demonstrate that the correlation between MCV and body mass is indirect, and is in reality due to the correlation between MCV and basal metabolic rate. This could be explained by the fact that small erythrocytes allow a fast release of oxygen in tissues with high metabolic demand. Nonetheless, hypoxia-adapted species show MCV greater than that predicted by their metabolic rate, while Ruminantia show the inverse. Interestingly, these species show the highest and lowest, respectively, Hb affinity for oxygen. In the present paper, I suggest that Hb–oxygen affinity, acting as a biological constraint for oxygen exchange, determines the size of red blood cells. Hb intrinsic affinity for oxygen shows little variation during evolution and modifying the levels of allosteric factors can be viewed as an adaption to adjust Hb–oxygen affinity to metabolic demands (the same also happens during ontogeny). Nonetheless, in some lineages, mutations raising Hb–oxygen affinity allowed some species to colonize hypoxic environments; in Ruminantia, instead, there was a drastic decrease, which cannot be adaptively explained.
Heterogeneous Treatment Effects after Inspiratory Muscle Training during Recovery from Postacute COVID-19 Syndrome
Authors: METCALFE RICHARD S. , SWINTON PAUL A. , MACKINTOSH KELLY A. , BERG RONAN M. G. , SHELLEY JAMES , SAYNOR ZOE L. , HUDSON JOANNE , DUCKERS JAMIE , LEWIS KEIR , DAVIES GWYNETH A. , MCNARRY MELITTA A. 
Published: May 2023

ABSTRACT

Purpose
The objective of this study is to investigate whether heterogeneous treatment effects occur for changes in inspiratory muscle strength, perceived dyspnea, and health-related quality of life after 8 wk of unsupervised home-based inspiratory muscle training (IMT) in adults with postacute coronavirus disease 2019 (COVID-19) syndrome.

Methods
In total, 147 adults with self-reported prior COVID-19 either completed an 8-wk home-based IMT intervention (n = 111, 92 females, 48 ± 11 yr, 9.3 ± 3.6 months postacute COVID-19 infection) or acted as “usual care” wait list controls (n = 36, 34 females, 49 ± 12 yr, 9.4 ± 3.2 months postacute COVID-19 infection).

Results
Applying a Bayesian framework, we found clear evidence of heterogeneity of treatment response for inspiratory muscle strength: the estimated difference between standard deviations (SD) of the IMT and control groups was 22.8 cm H2O (75% credible interval (CrI), 4.7–37.7) for changes in maximal inspiratory pressure (MIP) and 86.8 pressure time units (75% CrI, 55.7–116.7) for sustained MIP (SMIP). Conversely, there were minimal differences in the SD between the IMT and the control group for changes in perceived dyspnea and health-related quality of life, providing no evidence of heterogeneous treatment effects. Higher cumulative power during the IMT intervention was related to changes in MIP (β = 10.9 cm H2O (95% CrI, 5.3–16.8) per 1 SD) and SMIP (β = 63.7 (32.2–95.3) pressure time units per 1 SD), clearly indicating an IMT dose response for changes in inspiratory muscle strength. Older age (>50 yr), a longer time postacute COVID-19 (>3 months), and greater severity of dyspnea at baseline were also associated with smaller improvements in inspiratory muscle strength.

Conclusions
Heterogeneous individual responses occurred after an 8-wk home-based IMT program in people with postacute COVID-19 syndrome. Consistent with standard exercise theory, larger improvements in inspiratory muscle strength are strongly related to a greater cumulative dose of IMT.
Early Detection of Brain Metastases in a Supervised Exercise Program for Patients with Advanced Breast Cancer: A Case Report
Authors: PELAEZ MIREIA , STUIVER MARTIJN M. , BROEKMAN MARIKE , SCHMITZ KATHRYN H. , ZOPF EVA M. , CLAUSS DOROTHEA , WENGSTRÖM YVONNE , ROSENBERGER FRIEDERIKE , STEINDORF KAREN , URRUTICOECHEA ANDER , MAY ANNE M. 
Published: May 2023

ABSTRACT

Introduction
Around 25% of metastatic breast cancer (mBC) patients develop brain metastases, which vastly affects their overall survival and quality of life. According to the current clinical guidelines, regular magnetic resonance imaging screening is not recommended unless patients have recognized central nervous system–related symptoms.

Patient Presentation
The patient participated in the EFFECT study, a randomized controlled trial aimed to assess the effects of a 9-month structured, individualized and supervised exercise intervention on quality of life, fatigue and other cancer and treatment-related side effects in patients with mBC. She attended the training sessions regularly and was supervised by the same trainer throughout the exercise program. In month 7 of participation, her exercise trainer detected subtle symptoms (e.g., changes in movement pattern, eye movement or balance), which had not been noticed or reported by the patient herself or her family, and which were unlikely to have been detected by the oncologist or other health care providers at that point since symptoms were exercise related. When suspicion of brain metastases was brought to the attention of the oncologist by the exercise trainer, the response was immediate, and led to early detection and treatment of brain metastases.

Conclusion and clinical implications
The brain metastases of this patient were detected earlier due to the recognition of subtle symptoms detected by her exercise trainer and the trust and rapid action by the clinician. The implementation of physical exercise programs for cancer patients requires well-trained professionals who know how to recognize possible alterations in patients and also, good communication between trainers and the medical team to enable the necessary actions to be taken.
Multiblock Parameter Calibration in Computer Models
Authors: Jeong Cheoljoon , Xu Ziang , Berahas Albert S. , Byon Eunshin , Cetin Kristen 
Published: May 2023

Parameter calibration aims to estimate unobservable parameters used in a computer model by using physical process responses and computer model outputs. In the literature, existing studies calibrate all parameters simultaneously using an entire data set. However, in certain applications, some parameters are associated with only a subset of data. For example, in the building energy simulation, cooling (heating) season parameters should be calibrated using data collected during the cooling (heating) season only. This study provides a new multiblock calibration approach that considers such heterogeneity. Unlike existing studies that build emulators for the computer model response, such as the widely used Bayesian calibration approach, we consider multiple loss functions to be minimized, each for a block of parameters that use the corresponding data set, and estimate the parameters using a nonlinear optimization technique. We present the convergence properties under certain conditions and quantify the parameter estimation uncertainties. The superiority of our approach is demonstrated through numerical studies and a real-world building energy simulation case study. History: Bianca Maria Colosimo served as the senior editor for this article. Funding: This work was partially supported by the National Science Foundation [Grants CMMI-1662553, CMMI-2226348, and CBET-1804321]. Data Ethics & Reproducibility Note: The code capsule is available on Code Ocean at https://codeocean.com/capsule/8623151/tree/v1 and in the e-Companion to this article (available at https://doi.org/10.1287/ijds.2023.0029 ).
COMIDAS – VẼJẼN: ALIMENTAÇÃO NA COMUNIDADE KANHGÁG POR FI GA, SÃO LEOPOLDO
Authors: Amorim Gabriel Chaves 
Published: May 2023

A categoria vẽjẽn “comida” aparece para a população Kanhgág com diferentes marcadores sociais: para criança, vẽjẽn gῖr; para velho, vẽjẽn kofá ou classificada como boa, vẽjẽn mỹ rá. Através do trabalho de campo na comunidade Por Fi Ga, localizada em São Leopoldo, sistematizaram-se os momentos junto a uma análise etnológica fazendo uma leitura dos hábitos alimentares. O estudo demonstrou uma relação milenar com gêneros alimentícios não obstante uma constante transformação da memória ambiental, social e geracional, que criaram um espaço alimentar incorporador do novo e preservador de referências. Como resultado, o estudo aponta que a ligação dos moradores das emã si, comunidades pequenas, com as Terras Indígenas, T.I, emã mág, mostra-nos uma ponte que explica a predileção pelo feijão, banha, emi, fuvá e kumi. Esses são os principais gêneros preparados pelos moradores da Por Fi Ga, mas que também ocorrem em outras localidades, evidenciados aqui como marcadores culturais da interação com o ambiente, sociedade e economia.
Valuation of fisheries management status based on ecosystem approach (EA) in East Simeulue, Aceh
Authors: Aprilla Ratna Mutia , Dirgantini Celli , Miswar Edy , Rizwan Thaib , Rianjuanda Djamani , Salmarika Salmarika , Rahmah Alvi , Agustina Imelda , Mardiah Ratu Sari 
Published: May 2023

Fishery management is an activity that must be carried out to achieve sustainable fisheries. Fisheries management using the Ecosystem Approach to Fisheries Management (EAFM) approach is the sustainable use of fishery resources and protection of fish stocks in nature. One of the objectives of fisheries management in social and economic aspects is how fisheries can ensure the socio-economic welfare of the fishing community. Using fishing gear that is not environmentally friendly is one of the triggers for social conflict between fishermen and the uncertain selling price when the peak season of fish impacted the fishermen's economy. Therefore, the purpose of this research is to examine the socio-economic domain indicators from the aspect of EAFM-based coastal and marine resource ecosystem management. This research was conducted from January to February 2021, located in Simeulue District, Sub-District East Simeulue. The data collection method used in the study was interviews and field surveys. The determination of respondents is done by using a gradual sampling technique or stratified random sampling. Data analysis uses an ordinal-based Likert score of 1,2,3 for each indicator, namely the economic domain, fishery household income (RTP), savings ratio, asset ownership, and the social domain, namely stakeholder participation fisheries conflict and the use of local knowledge in fish resource management. Management status in East Simeulue District assessed the aggregate value of the economic domain in the medium category with a score of 48.3. Fishermen still earn less than the minimum wage, while in the social domain, it is in the excellent category with a score of 100 because fishermen, institutions, and related agencies work with each other. Keywords:EAFMEcosystem approachFishery management
Evidence of Histoplasma capsulatum seropositivity and exploration of risk factors for exposure in Busia county, western Kenya: Analysis of the PAZ dataset
Authors: Cornell Tessa Rose , Thomas Lian Francesca , Cook Elizabeth Anne Jessie , Pinchbeck Gina , Bettridge Judy , Gordon Lauren , Kivali Velma , Kiyong’a Alice , Fèvre Eric Maurice , Scantlebury Claire Elizabeth 
Published: May 2023

BackgroundDespite recognition of histoplasmosis as a disease of national public health concern in Kenya, the burden ofHistoplasma capsulatumin the general population remains unknown. This study examined the human seroprevalence of anti-Histoplasmaantibody and explored associations between seropositivity and demographic and environmental variables, in Busia county, western Kenya.MethodologyBiobanked serum samples and associated data, from a previous cross-sectional survey, were examined. Latex agglutination tests to detect the presence of anti-Histoplasmaantibody were performed on serum samples from 670 survey respondents, representing 178 households within 102 sub-locations.Potential epidemiologic risk factors forH.capsulatumexposure were explored using multi-level multivariable logistic regression analysis with household and sub-location included as random effects.Principal findingsThe apparent sample seroprevalence of anti-Histoplasmaantibody was 15.5% (n= 104/670, 95% Confidence Interval (CI) 12.9–18.5%). A multivariable logistic regression model identified increased odds ofH.capsulatumseropositivity in respondents reporting rats within the household within the previous 12 months (OR = 2.99 90% CI 1.04–8.55,p= 0.04). Compared to respondents aged 25–34 years, the odds of seropositivity were higher in respondents aged 15–24 years (OR = 2.70 90% CI 1.04–6.97,p= 0.04).ConclusionsThe seroprevalence result provides a baseline for sample size approximations for future epidemiologic studies of the burden ofH.capsulatumexposure in Busia county. The final model explored theoretically plausible risk factors forH.capsulatumexposure in the region. A number of factors may contribute to the complex epidemiological picture impactingH.capsulatumexposure status at the human-animal-environment interface in western Kenya. FocussedH.capsulatumresearch is warranted to determine the contextual significance of identified associations, and in representative sample populations.
Validation of the Nelwan Score as a screening tool for the diagnosis of typhoid fever in adults in Indonesia
Authors: Nelwan Erni Juwita , Paramita Luh Putu Listya , Sinto Robert , Subekti Decy , Hosea Fransiscus Nikodemus , Nugroho Pringgodigdo , Pohan Herdiman T. 
Published: May 2023

Introduction
Typhoid fever diagnosis is challenging for clinicians in areas with limited laboratory facilities. Scoring methods based on signs and symptoms are useful for screening for probable cases of typhoid fever. The Nelwan Score variables are derived from the clinical signs and symptoms of patients with suspected typhoid. We validated the Nelwan Score compared to laboratory tests as the gold standard.

Methods
This cross-sectional study was conducted between July 2017 and January 2018 in five hospitals and two primary health care centers in Jakarta and Tangerang, Indonesia. Patients with fever for 3–14 days and gastrointestinal symptoms were evaluated using the Nelwan Score. Blood cultures, samples for polymerase chain reaction testing, and additional rectal swab cultures were collected simultaneously to confirm the diagnosis of typhoid. Data were analyzed using a contingency table to measure sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), and the optimal cut-off of the Nelwan Score for typhoid diagnosis was determined using a receiver-operating characteristic curve.

Result
Typhoid was confirmed in 11 of the 233 patients (4.7%) with suspected typhoid. Among laboratory-confirmed typhoid cases, the median Nelwan Score was 11 (range: 9–13) and the optimal cut-off value was 10, with an area under the curve of 71.3%, sensitivity of 81.8%, specificity of 60.8%, PPV of 9.3%, and NPV of 98.5%.

Conclusion
A Nelwan Score of 10 is the best cut-off value for screening for typhoid fever. It is useful as screening tool for typhoid fever, where laboratory resources are limited, and could help to decrease irrational antibiotic use.
Use of high cost care among Veterans with comorbid mental illness and Alzheimer’s Disease and related dementias
Authors: Shepherd-Banigan Megan , Miller Katherine E. M. , Hastings S. Nicole , Schleiden Loren J. , Thorpe Joshua M. 
Published: May 2023

Introduction/Objective
Alzheimer’s Disease and Other Related Dementias (AD/ADRD) leads to frequent emergency department (ED) and inpatient use. Mental health symptoms among persons with AD/ADRD increases cognitive and functional disabilities and could contribute to these high rates of intensive health care use. The objective of this paper is to assess the relationship of mental illness on 12-month patterns in hospitalization and ED use among Veterans aged 65 and over with a new AD/ADRD diagnosis.

Methods
We used an existing dataset of administrative electronic health record data of Veterans with AD/ADRD from the US Veterans Health Administration linked with Medicare claims data from 2011–2015. We use multivariable logistic regression to examine the association between no pre-existing mental illness, pre-existing mental illness (e.g., major depressive disorder, generalized anxiety disorder, or post-traumatic stress disorder), and pre-existing severe mental illness—or SMI—(e.g., bipolar disorder, major depressive disorder with psychosis, or schizophrenia) and 12- month ED and hospitalization use and readmissions among Veterans who had an initial hospitalization visit. We estimated predicted probabilities, differential effect, and associated 95% confidence intervals.

Results
In our sample, 1.4% had SMI and 11% had non-SMI mental illness. The unadjusted percentage with inpatient and ED use was higher among Veterans with SMI (34% and 26%, respectively) and Veterans with non-SMI mental illness (20%, 16%) compared with Veterans without pre-existing mental illness (12%, 9%). Compared to individuals with no pre-existing mental illness, having a pre-existing mental illness (1.27 percentage points, 95% CI: 0.76, 1.78) and a pre-existing SMI (7.17 percentage points, 95% CI: 5.66, 8.69) were both associated with an increased likelihood of ED use. The same pattern was observed for any inpatient use (mental illness 2.18, 95% CI: 1.59, 2.77; SMI 9.91, 95% CI: 8.21, 11.61). Only pre-existing SMI was associated higher hospitalization readmission.

Discussion
Pre-existing mental illness increases use of high cost, intensive health care and this association is higher of more severe mental health conditions. We also show that pre-existing mental illness exerts a unique influence, above and beyond other comorbidities, such as diabetes, on ED and inpatient visits. More needs to be done to increase recognition of the unique risks of this combination of health conditions and encourage strategies to address them. Developing, testing, and implementing comprehensive strategies that address the intersection of ADRD and mental illness is promising approach that requires more focused attention.
How are families in Germany doing in 2022? Study protocol of a nationally representative, cross-sectional study of parents with children aged 0–3 years
Authors: Neumann Anna , Ulrich Susanne M. , Sinß Frank , Chakraverty Digo , Hänelt Maria , Lux Ulrike , Ghezih Sarah , Löchner Johanna , Renner Ilona 
Published: May 2023

Background
In order for Early Childhood Intervention (ECI) to be effective, data-based information on families’ resources, burden and current use of support services for families with young children, as well as on children’s health and development is needed. The study Kinder in Deutschland [Children in Germany]–KiD 0–3 2022 aims at providing these data to help us understand families’ situation and needs in Germany now, including families’ experience of the COVID-19 pandemic.

Method
The study will recruit up to 300 pediatricians who will invite parents of children aged up to 48 months to participate in the study during a well-child visit. Parents (goal N = 8,000) will complete an online-questionnaire with their own web-enabled device. Pediatricians will complete a short questionnaire about each participating family. The questionnaires cover family psychosocial burden and resources, child health and development, use of family support services, as well as the families’ experiences of the COVID-19 pandemic. Data will be analyzed to assess patterns of families´ psychosocial burdens and resources, use of support services for families with young children, and children´s health and development. Concordance between parent and pediatrician report will be assessed and comparisons with the predecessor study of 2015 will be drawn.

Dissemination
Findings will be disseminated through scientific conferences, open access peer-reviewed journals, and dissemination channels of the National Centre for Early Prevention.

Discussion
The present study will provide parent and pediatrician reports on how families with young children are doing in Germany. These data will be used to inform Germany’s early childhood intervention (ECI) program (“Frühe Hilfen”) on current needs of families with young children.
Pemanfaatan Limbah An-Organik Sebagai Karya Busana: Studi Kasus di MAN 2 Kulon Progo
Authors: Winarni Esti 
Published: May 2023

Tujuan – Penelitian ini bertujuan untuk mendeskripsikan tentang pengajaran kepada siswa terkait pemanfaatan limbah sampah an-organik sebagai bahan karya busana untuk meningkatkan pemahaman tentang keberlanjutan dan peduli lingkungan di MAN 2 Kulon Progo.
Metode – Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Lokasi penelitian ini adalah di MAN 2 Kulon Progo. Yang menjadi subjek dalam penelitian ini siswa-siswi kelas X dan XI. Teknik pengumpulan data yang digunakan oleh peneliti dalam penelitian ini yaitu dengan observasi, wawancara dan dokumentasi. Sedangkan teknik analisis data yang digunakan dalam penelitian ini adalah analisis interaktif dari Milles & Huberman dan Saldana yaitu pengumpulan data, kondesasi data, penyajian data, dan penarikan kesimpulan/verifikasi. Keabsahan data dalam penelitian kualitatif meliputi uji credibility, transferability, dependability, dan confirmability.
Hasil – Limbah an-organik dari perca kain dan limbah plastik bisa ditingkatkan kualitasnya dengan cara (recycle) menjadi karya busana yang bernilai ekonomis. Dalam meningkatkan kualitas limbah an-organik menjadi karya busana yang bernilai ekonomis diperlukan kreatifitas siswa dan guru pembimbing,sehingga akan tercipta suatu karya yang memuaskan. Oleh karena itu, dalam mengelola limbah untuk mewujudkan madrasah yang berwawasan lingkungan perlu dukungan seluruh warga madrasah.Sehingga akan tercipta lingkungan madrasah yang bersih dan asri, sehingga akan memberikan suasana yang sehat, dan nyaman untuk beraktifitas.