bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravenous thrombolysis for patients with acute ischemic stroke while receiving a direct oral anticoagulant: A systematic review and meta‐analysis
Authors: Roberts Megan Z. , Durham Spencer H. , Pinner Nathan A. , Starr Jessica A. 
Published: January 2025

AbstractRecent guidelines for acute ischemic stroke (AIS) indicate administration of intravenous thrombolysis (IVT) in patients receiving direct oral anticoagulants (DOAC) is not firmly established and may be harmful unless certain potential parameters are met. This systematic review and meta‐analysis explores safety outcomes and other clinical parameters from the growing number of publications describing patients taking a DOAC who experience an AIS that is treated acutely with IVT alone. Embase, International Pharmaceutical Abstracts, and PubMed were searched up to January 9, 2024 for studies including adult patients taking a DOAC who experienced an AIS treated with IVT and did not undergo endovascular therapy (EVT), regardless of the use of an anticoagulation reversal agent. Primary safety outcomes evaluated included symptomatic intracranial hemorrhage (sICH), any intracranial hemorrhage, and in‐hospital mortality. A total of 873 patients from 78 studies, primarily case reports or case series of patients receiving dabigatran with or without idarucizumab reversal (n = 340), were included in the review. The rate of sICH during the index hospitalization was 3.3%. Seven high‐quality studies with low risk of bias included outcomes for patients on DOAC and comparator groups of either patients not taking an oral anticoagulant (no OAC) or patients taking a vitamin K antagonist (VKA) with INR primarily <1.7 at the time of AIS. No significant difference was observed in the incidence of sICH among patients receiving DOAC vs. no OAC (odds ratio [OR] 0.8, 95% confidence interval [CI]: 0.48–1.33) or among patients receiving DOAC vs. VKA (OR 1.02, 95% CI 0.59–1.75). Similar findings of no difference were observed for other safety outcomes. Findings from this study suggest that utilization of IVT as sole recanalization therapy for AIS may be safe in patients taking a DOAC; however, further studies are needed to elucidate specific parameters that differentiate timepoints and variables to ensure safe, optimal treatment.
Development of Micro‐Crosslinked Poly(L‐Lactic Acid) With Flexible, Anti‐Aging, and Barrier Properties by In Situ Polymerization of Graphene Oxide
Authors: Zhang Jiatao , Dong Tungalag , Zhang Yuan , Guo Jia , Li Yulu , Yun Xueyan 
Published: January 2025

ABSTRACTAlthough poly(L‐lactic acid) (PLLA) is biocompatible and degradable, its inherent brittleness, susceptibility to aging, low ultraviolet light (UV) resistance, and moderate gas barrier properties limit its diverse applications. In this study, graphene oxide (GO) was used as an initiator, unsaturated poly (butylene itaconate) (PBI) was used as a flexible chain segment, and GO‐grafted P(LA‐g‐BI) (GO‐g‐PLBI) copolymer was synthesized by in situ melt polycondensation of lactic acid. Nuclear magnetic resonance, Fourier transform infrared, and X‐ray photoelectron spectroscopy results confirmed the successful synthesis of GO‐g‐PLBI and the formation of a multi‐branched structure. The GO‐g‐PLBI film demonstrated excellent ductility and oxygen barrier properties, with elongation at break increased by 73.8 times compared with PLLA, while oxygen permeability (OP) decreased by 40.3%. The incorporation of PBI facilitated micro‐crosslinking within the copolymer, thereby enhancing its thermal stability. More gg and gt conformations were formed in the copolymer, while the crystallization of the copolymer induced by aging was inhibited, thus showing excellent anti‐aging properties. Interestingly, the OP value of this micro‐crosslinked GO‐g‐PLBI film decreased by 60.9% after physical aging, demonstrating extremely high oxygen barrier properties. This study offers a viable approach to developing PLLA/graphene nanocomposites that exhibit adjustable flexibility, enhanced oxygen barrier, heat and UV resistance, anti‐aging properties, and high transparency.
Effect of an Instructional Program in Foundational Reading Skills on Early Literacy Development of Students in Kindergarten and First Grade
Authors: Lane Holly B. , Contesse Valentina A. , Gage Nicholas A. , Burns Matthew K. 
Published: January 2025

AbstractResearch has demonstrated the positive effects of systematically teaching phonemic awareness and phonics in kindergarten and first grade, but many commonly used reading curricula do not adequately incorporate these foundational skills. In this study, we examined the efficacy of an instructional program (UFLI Foundations) in foundational reading skills (i.e., phonemic awareness and phonics) with students in kindergarten and first grade. We compared students who received a full year of the instructional program to propensity score matched control students, who received business‐as‐usual instruction, with a cross‐cohort quasi‐experimental design. Multilevel modeling results demonstrated that adding instruction in foundational skills increased early literacy skills scores by more than 1.0 standard deviation. Further, we found that students of teachers who taught with greater adherence to the UFLI Foundations program had larger effects. Implications and future directions are discussed.
Femtosecond Laser Ablation (fs‐LA) XPS Depth Profiling of Lead Halide Perovskite Thin Film Solar Cells
Authors: Chandler C. W. , Devadasan D. S. , Bacon S. R. , Yun J. S. , Park H. H. , Nunney T. S. , Baker M. A. 
Published: January 2025

ABSTRACTMixed organic–inorganic halide perovskites are finding strong interest as thin film solar cell materials. XPS depth profiling of a spin‐coated (FAPbI3)0.95(MAPbBr3)0.05 perovskite thin‐film solar cell, has been performed. Profiles have been recorded using traditional monatomic and cluster ion beam bombardment and compared to those obtained using a new femtosecond laser ablation (fs‐LA) approach. The femtosecond laser employed has a wavelength of 1030 nm and a pulse length of 160 fs. Monatomic and cluster ion sputter depth profiling of the halide perovskite results in preferential sputtering of C, N and I and the appearance of Pb0 in the Pb 4f spectrum as a preferential sputtering artefact. fs‐LA depth profiling is shown to retain the original composition and chemical state information of the perovskite layer with no chemical damage. An ablation rate of ≈33 nm through the perovskite layer was found at an incident laser energy of 42 μJ per pulse. A combined fs‐LA/monatomic sputtering depth profile enabled all layers in the cell to be identified whilst retaining the true composition of the perovskite layer.
Promoting CO2 Methanation Activity of NiAl Mixed Metal Oxide Catalysts Through Hydrophobicity Control
Authors: Lee Ju Hyeong , Kim Kwang Young , Oh Daewon , Byun Woo Jin , Lee Jae Sung 
Published: January 2025

AbstractDuring CO2 methanation, the generation of H2O as a by‐product can lead to its strong adsorption on the catalyst's active sites, potentially blocking them or altering the active phase, thereby degrading catalytic performance. To mitigate this inhibition effect by water, we introduce a hydrophobic surface via stearic acid treatment to rapidly remove H2O formed during CO2 methanation over NiAl mixed metal oxide (MMO)‐derived catalysts. The crystal structure of NiAl MMO and the average Ni particle size of ∼13 nm remain unaltered by the hydrophobic treatment. The NiAl catalyst treated with an optimal concentration of stearic acid shows a nearly doubled CO2 conversion of 61.4% at 275 °C, compared to the pristine catalyst, and this high activity is sustained for over 100 h without deactivation. However, excessive stearic acid coverage inhibits CO2 adsorption significantly, causing a sharp drop in CO2 conversion to 10.8%. This study demonstrates that hydrophobic surface modification can effectively ameliorate catalyst deactivation due to by‐product H2O, which could be applied to many other catalytic reactions where H2O acts as an inhibiting by‐product.
Does Meaning in Life Mediate Associations Between Suffering and Subsequent Mental Well‐Being? Longitudinal Evidence From Two Non‐Western Samples
Authors: Cowden Richard G. , Fung Eric N. , Bechara Andrea O. , Cook Kaye V. , Kurniati Ni Made Taganing , Suwartono Christiany , Widyarini Nilam , VanderWeele Tyler J. 
Published: January 2025

ABSTRACTNarrative accounts have documented the potential for suffering to degrade a person's well‐being by undermining their sense of meaning in life, but few studies have investigated this among nonclinical samples living in non‐Western contexts of the Global South. Leveraging data from a set of three‐wave longitudinal studies with younger Indonesian (Study 1: Wave 1 [December 2020], Wave 2 [January 2021], Wave 3 [February 2021]; N = 620) and Colombian adults (Study 2: Wave 1 [August/September 2021], Wave 2 [October/November 2021], Wave 3 [February 2022]; N = 2626), the present research used causal mediation methods within a counterfactual framework to examine whether the associations between suffering (Wave 1) and subsequent anxiety symptoms, depression symptoms, and general mental health (Wave 3) are mediated by meaning in life (Wave 2). Mediation analyses in both studies provided some evidence indicating that overall suffering (Wave 1) is indirectly associated with worse subsequent mental well‐being on all three outcomes (Wave 3) via lower meaning in life (Wave 2). Results were generally consistent with those found for overall suffering when the aspects of suffering were considered individually, although in Study 1 the evidence in support of mediation was stronger and more consistent for some aspects of suffering compared to others. Over both shorter (Study 1) and longer (Study 2) time lags, the findings suggest that meaning in life may be one of the mechanisms by which suffering degrades mental well‐being. Practical implications for mitigating and transcending the deleterious effects of suffering on mental well‐being are discussed.
Nanopore Detection of Small Molecules Based on Replacement and Complexation Chemical Interactions
Authors: Zheng Haiyan , Munusamy Sathishkumar , Zhou Shuo , Jahani Rana , Chen Jun , Kong Juanhua , Guan Xiyun 
Published: January 2025

AbstractSmall molecules play important roles in a variety of biological processes such as metabolism, cell signaling and enzyme regulation, and can serve as valuable biomarkers for human diseases. Moreover, they are essential to drug discovery and development, and are important targets for environmental monitoring and food safety. Due to the size incompatibility, small molecule transport is difficult to be monitored with a nanopore. A popular strategy for nanopore detection of small molecules is to introduce a molecular probe as a ligand (or recognition element) and rely on their effect on the ligand transport. One limitation for this sensing strategy is that the probe molecule needs to have a slightly smaller size than the nanopore constriction or can be easily unfolded or unzipped through the pore. Herein, by taking advantage of replacement and complexation chemical interactions, a generic approach is reported for detection of small molecules by using large biomolecules with well‐defined stable 3D structures such as aptamers as recognition elements. Given the versatile use of aptamers as capture agents for a wide variety of species, the developed nanopore sensing strategy should find applications in many fields.
Use of Quantum Dots as Nanotheranostic Agents: Emerging Applications in Rare Genetic Diseases
Authors: K M Neethu , Karmakar Shyamal , Sahoo Baishakhi , Mishrra Navniet , Moitra Parikshit 
Published: January 2025

AbstractRare genetic diseases (RGDs) affect a small percentage of the global population but collectively have a substantial impact due to their diverse manifestations. Although the precise reasons behind these diseases remain unclear, roughly 80% of cases are genetically linked. Recent efforts focus on understanding pathology and developing new diagnostic and therapeutic approaches for RGDs. However, there persists a gap between fundamental research and clinical therapeutic approaches, where advancements in nanotechnology offer promising improvements. In this context, nanosized light‐emitting quantum dots (QDs), ranging from 2–10 nm, are promising materials for diverse applications. Their size‐tunable light emission, high quantum yield, and photostability allow for precise tracking of cargo. Additionally, QDs can be functionalized with therapeutic agents, antibodies, or peptides to target specific cellular pathways, enhancing treatment efficacy while minimizing side effects. By combining diagnostic and therapeutic capabilities in a single platform, QDs thus offer a versatile and powerful approach to tackle rare genetic disorders. Despite several reviews on various therapeutic applications of QDs, their utilization in the specific domain of RGDs is not well documented. This review highlight QDs’ potential in diagnosing and treating certain RGDs and addresses the challenges limiting their application.
Janus Protein Nanoparticles Tailoring Bicontinuous Aerogels for Efficient Heavy Metal Ion Absorption
Authors: Wang Zhigao , Chen Yao , Li Xuyuan , Wang Lifeng , Binks Bernard P. , Wang Tao 
Published: January 2025

AbstractBicontinuous structures are exquisite interpenetrating constructs with an optimal balance between connectivity and surface area. Such unique geometry favors exceptional mechanical properties and efficient inward mass diffusion essential for an absorbent material. Although bicontinuous structures are found across many length scales in nature, synthesizing artificial analogs using biological building blocks remains largely unexplored. In this study, it is shown that manipulation of the surface chemistry of rapeseed cruciferin nanoparticles (≈50 nm) leads to the formation of a highly amphiphilic stabilizer, ensuring equal wetting of water and oil phases in a demixed system, thereby enabling the formation of bicontinuous emulsions. By further eliminating both volatile liquid phases (water and toluene) through freeze‐drying, bicontinuous emulsions are transformed into bicontinuous aerogels featuring highly interpenetrating networks with uniform domain size. These materials, characterized by high surface area (224 m2 g−1) and mechanical robustness, can efficiently absorb various heavy metal ions multiple times displaying excellent absorption capacity (up to 200 mg g−1) and efficiency (less than 30 min). This study is at the forefront of constructing biomacromolecular bicontinuous structures, potentially expanding their applications in diverse fields such as food, cosmetics, and medicine.
Strong Interfacial Interaction in Polarized Ferroelectric Heterostructured Nanosheets for Highly Efficient and Selective Photocatalytic CO2 Reduction
Authors: Liu Xiao , Wang Yuyin , Tian Wenchao , Zhu Fangyuan , Wang Jicong , Wang Weijia , Li Yanrui , Zeng Kaizhu , Shi Jing 
Published: January 2025

AbstractHeterojunctions are sustainable solutions for the photocatalytic CO2 reduction reaction (CO2RR) by regulating charge separation behavior at the interface. However, their efficiency and product selectivity are severely hindered by the inflexible and weak built‐in electric field and the electronic structure of the two phases. Herein, ferroelectric‐based heterojunctions between polarized bismuth ferrite (BFO(P)) and CdS are constructed to enhance the interfacial interactions and catalytic activity. The intrinsic polarization field depending on the ferroelectric state causes significant electrostatic potential difference and energy‐band bending. This helps overcome the unsatisfactory redox potential that differs from the classical catalytic mechanism, and synergy from the heterostructure facilitates effective separation and transfer of photogenerated charges with an extended lifetime (>20 ns) and significantly enhanced photovoltage (1002 times that of BFO). The optimized charge carrier dynamics allow the heterojunction to achieve a much higher CO yield compared to state‐of‐the‐art ferroelectric‐based photocatalysts, and 85.46 and 23.47 times higher than those of pristine CdS and BFO, respectively. Moreover, it maintains an impressive 100% product selectivity together with excellent repeatability and cycling. This work not only sheds light on how a strong inherent polarity promotes the performance of heterojunction photocatalysts but also provides new insights for designing efficient photocatalytic CO2RR.
Photothermal Material‐Based Solar‐Driven Cogeneration of Water and Electricity: An Efficient and Promising Technology
Authors: Bao Xiangxin , Luo Haopeng , Weng Tingyi , Chen Zihan , Yan Xing , An Fengxia , Jiang Fang , Chen Huan 
Published: January 2025

AbstractWith the increasing demand for fresh‐water and electricity in modern society, various technologies are being explored to obtain fresh‐water and electricity. Due to advances in materials science, solar‐driven interfacial evaporation (SDIE) systems have attracted widespread attention because they require only solar energy, and possess a high evaporation rate and little pollution. The researchers combined energy harvesting measures into the system to output electricity, further improving energy utilization. However, more in‐depth research and review remain on using SDIE systems for efficient water‐electricity cogeneration. Therefore, the mechanisms of different photothermal materials that utilize solar energy to produce thermal energy are first summarized in this paper. Subsequently, the mechanism and application of thermal, mechanical, chemical, and evaporation energy to produce electrical power in SDIE water‐electricity cogeneration systems are discussed. Concurrently, vital mathematical equations and widely used mathematical simulation methods for performance evaluation and practical applications are presented. The design and operation of water‐electricity cogeneration systems based on photothermal materials are analyzed and summarized. Based on a review and in‐depth understanding of these aspects, the future development direction of cogeneration is proposed to address the problems faced in basic research and practical applications.
Charge Capacitive Signatures at the Interface of E. coli/MOF Biohybrids to Create a Live Cell Biocapacitor
Authors: Andrew Ndepana , Trofe Anthony , Laws Eric , Pathiraja Gayani , Kalkar Swapna , Ignatova Tetyana , Rathnayake Hemali 
Published: January 2025

AbstractThe chemistry of the extracellular electron transfer (EET) process in microorganisms can be understood by interfacing them with abiotic materials that act as external redox mediators. These mediators capture and transfer extracellular electrons through redox reactions, bridging the microorganism and the electrode surface. Understanding this charge transfer process is essential for designing biocapacitors capable of modulating and storing charge signatures as capacitance at the electrode interface. Herein, a novel biointerfacial strategy is presented to investigate directional charge injection from a non‐exoelectrogenic living microbe to an electrode surface using the porous metal–organic framework (MOF), MIL‐88B. The biohybrid, formed by interfacing Escherichia coli (E. coli) with MIL‐88B, demonstrates symbiotic interactions between the biotic and abiotic components, facilitating EET from E. coli to the electrode via the MOF. Acting as a redox mediator, the MOF catalyzes E. coli's exoelectrogenic activity, generating distinct charge capacitive signatures at the E. coli‐MOF interface. This system integrates the capacitive signatures resulting from the EET process with the MOF's intrinsic pseudocapacitive properties and surface‐controlled capacitive effects, functioning as a highly efficient biocapacitor. Furthermore, this approach of converting the biochemical energy of a non‐exoelectrogenic microorganism into capacitive signatures opens a new pathway for translating biological signals into functional outputs, paving the way for autonomous biosensing platforms.
Tetrahedral Framework Nucleic Acid (tFNA)‐Loaded Metformin (Met) Modulates Cellular Pyroptosis and AMPK to Ameliorate Type II Diabetic Periodontitis
Authors: Han Qi , Li Jiaqi , Deng Hao , Shi Sirong , Zhou Mi , Cai Xiaoxiao , Chen Yu , Lin Yunfeng 
Published: January 2025

AbstractDiabetic periodontitis presents a unique therapeutic challenge, primarily due to its chronic inflammatory profile and the associated bone loss driven by immune dysregulation. Metformin (Met) is recognized for its potent anti‐inflammatory properties, yet its limited cellular uptake has hindered its clinical effectiveness in diabetic periodontitis. A tetrahedral framework nucleic acid (tFNA)‐based delivery system is developed to enhance Met cellular uptake and investigate its effects on diabetic periodontitis in this study. The tFNA‐loaded Met complex (TMC) demonstrates efficient Met loading efficiency and rapid cellular internalization. These results show that in vitro, TMC significantly inhibited pro‐inflammatory cytokines and matrix metalloproteinaseat both mRNA and protein levels under high glucose conditions. Mechanistically, TMC suppresses NLRP3‐mediated pyroptosis by downregulating NLRP3, Caspase‐1, Caspase‐11, and GSDMD, ultimately reducing Mature‐IL‐1β and Mature‐IL‐18 production. Furthermore, TMC activates AMPK while inhibiting NF‐κB signaling, thus mitigating the inflammatory response in diabetic periodontitis. In vivo, intraperitoneal administration of TMC in a diabetic periodontitis mouse model significantly reduces inflammatory cell infiltration, collagen degradation, and osteoclast formation, thus alleviating alveolar bone loss. These findings highlight the therapeutic potential of tFNA as an efficient Met delivery vehicle to tackle diabetic periodontitis‐associated inflammation and bone resorption, providing a promising strategy for managing diabetic complications.
Impact of Functional Fluorinated Porphyrins on the Efficiency and Stability of Perovskite Solar Cells
Authors: Mai Chi‐Lun , Hung Chieh‐Ming , Huang Zhen‐Hao , Chen Bo‐Han , Wang Meng‐Chuan , Ho Fang‐Chi , Tsai Hsiao‐Chun , Liu Zong‐Han , Yang Shang‐Da , Chou Pi‐Tai , Chen Hsieh‐Chih , Yeh Chen‐Yu 
Published: January 2025

AbstractAdditives play a pivotal role in enhancing the efficiency of perovskite solar cells (PSCs), and carefully designed additives contribute to major breakthroughs in device performance. In this study, a series of novel A–π–A‐type porphyrin derivatives—PPH‐1, PPH‐2, and PPF‐1—are synthesized, each incorporating pyridyl groups, specifically engineered to function as passivation agents for PSCs. The electron‐withdrawing properties of fluorine in PPF‐1 increase the molecular polarity, thereby strengthening its interaction with the perovskite and enhancing the passivation efficacy. Compared to PPH‐1 and PPH‐2, PPF‐1 not only improves crystallinity but also provides more efficient defect passivation at grain boundaries and interfaces. As a result, PSCs incorporating PPF‐1 achieve a remarkable power conversion efficiency (PCE) of 24.96%, along with an open‐circuit voltage (VOC) of 1.178 V, a short‐circuit current density (JSC) of 24.65 mA cm−2, and a fill factor (FF) of 85.96%, surpassing the PCEs of 23.36%, 24.11%, and 23.93% for pristine, PPH‐1‐, and PPH‐2‐modified PSCs, respectively. In addition, the incorporation of fluorinated porphyrin in PPF‐1 significantly improves the moisture resistance and thermal stability, while the device maintains high solar efficiency, opening up new alternative ways to promote solar cell innovation.