bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Frailty by the French Version of the Vulnerable Elders Survey-13 on Digital Tablet: Validation Study
Authors: Zolnowski-Kolp Victoria , Um Din Nathavy , Havreng-Théry Charlotte , Pariel Sylvie , Veyron Jacques-Henri , Lafuente-Lafuente Carmelo , Belmin Joel 
Published: May 2023

Background
Frailty assessment is a major issue in geriatric medicine. The Vulnerable Elders Survey-13 (VES-13) is a simple and practical tool that identifies frailty through a 13-item questionnaire completed by older adults or their family caregivers by self-administration (pencil and paper) or by telephone interview. The VES-13 provides a 10-point score that is also a recognized mortality predictor.

Objective
This study aims to design an electronic version of the Echelle de Vulnérabilité des Ainés-13, the French version of the VES-13 (eEVA-13) for use on a digital tablet and validate it.

Methods
The scale was implemented as a web App in 3 different screens and used on an Android tablet (14.0× 25.6 cm). Participants were patients attending the outpatient clinic of a French geriatric hospital or hospitalized in a rehabilitation ward and family caregivers of geriatric patients. They completed the scale twice, once by a reference method (self-administered questionnaire or telephone interview) and once by eEVA-13 using the digital tablet. Agreement for diagnosis of frailty was assessed with the κ coefficient, and scores were compared by Bland and Altman plots and interclass correlation coefficients. User experience was assessed by a self-administered questionnaire.

Results
In total, 86 participants, including 40 patients and 46 family caregivers, participated in the study. All family caregivers had previously used digital devices, while 13 (32.5%) and 10 (25%) patients had no or infrequent use of them previously. We observed no failure to complete the eEVA-13, and 70% of patients (28/40) and no family caregivers needed support to complete the eEVA-13. The agreement between the eEVA-13 and the reference method for the diagnosis of frailty was excellent (κ=0.92) with agreement in 83 cases and disagreement in 3 cases. The mean difference between the scores provided by the 2 scales was 0.081 (95% CI–1.263 to 1.426). Bland and Altman plots showed a high level of agreement between the eEVA-13 and the reference methods and interclass correlation coefficient value was 0.997 (95% CI 0.994-0.998) for the paper and tablet group and 0.977 (95% CI 0.957-0.988) for the phone and tablet groups. The tablet assessment was found to be easy to use by 77.5% (31/40) of patients and by 96% (44/46) of caregivers. Finally, 85% (39/46) of family caregivers and 50% (20/40) of patients preferred the eEVA-13 to the original version.

Conclusions
The eEVA-13 is an appropriate digital tool for diagnosing frailty and can be used by older adults and their family caregivers. The scores obtained with eEVA-13 are highly correlated with those obtained with the original version. The use of health questionnaires on digital tablets is feasible in frail and very old patients, although some patients may need help to use them.
The Synergistic Effect of Nurse Proactive Phone Calls With an mHealth App Program on Sustaining App Usage: 3-Arm Randomized Controlled Trial
Authors: Wong Arkers Kwan Ching , Bayuo Jonathan , Wong Frances Kam Yuet , Chow Karen Kit Sum , Wong Siu Man , Lau Avis Cheuk Ki 
Published: May 2023

Background
Although mobile health application (mHealth app) programs have effectively promoted disease self-management behaviors in the last decade, usage rates have tended to fall over time.

Objective
We used a case management approach led by a nurse and supported by a health-social partnership team with the aim of sustaining app usage among community-dwelling older adults and evaluated the outcome differences (i.e, self-efficacy, levels of depression, and total health service usages) between those who continued to use the app.

Methods
This was a 3-arm randomized controlled trial. A total of 221 older adults with hypertension, diabetes, or chronic pain were randomized into 3 groups: mHealth (n=71), mHealth with interactivity (mHealth+I; n=74), and the control (n=76). The mHealth application was given to the mHealth and mHealth+I groups. The mHealth+I group also received 8 proactive calls in 3 months from a nurse to encourage use of the app. The control group received no interventions. Data were collected at preintervention (T1), postintervention (T2), and at 3 months’ postintervention (T3) to ascertain the sustained effect.

Results
A total of 37.8% of mHealth+I and 18.3% of mHealth group participants continued using the mHealth app at least twice per week until the end of the sixth month. The difference in app usage across the 2 groups between T2 and T3 was significant (χ21=6.81, P=.009). Improvements in self-efficacy (β=4.30, 95% CI 0.25-8.35, P=.04) and depression levels (β=–1.98, 95% CI –3.78 to –0.19, P=.03) from T1 to T3 were observed in the mHealth group participants who continued using the app. Although self-efficacy and depression scores improved from T1 to T2 in the mHealth+I group, the mean values decreased at T3. Health service usage decreased for all groups from T1 to T2 (β=–1.38, 95% CI –1.98 to –0.78, P<.001), with a marginal increase at T3.

Conclusions
The relatively low rates of mHealth app usage at follow-up are comparable to those reported in the literature. More work is needed to merge the technology-driven and in-person aspects of mHealth.

Trial Registration
ClinicalTrials.gov NCT03878212; https://clinicaltrials.gov/ct2/show/NCT03878212

International Registered Report Identifier (IRRID)
RR2-10.1159/000509129
DEVELOPMENT AND IN VITRO EVALUATION OF NANOLIPID CARRIERS OF CLOBETASOL PROPIONATE AND PRAMOXINE HYDROCHLORIDE FOR TOPICAL DELIVERY
Authors: Mohan Dixit C. , Suresh Akhil , Mukundan Shilpa , Gupta Swati , Viswanad Vidya 
Published: May 2023

Objective: Formulation and characterization of clobetasol propionate (CP) and pramoxine hydrochloride (PH) loaded nanostructured lipid carriers (NLC) offering improved performance in terms of drug loading and long-term stability for topical drug delivery.
Methods: Drug-loaded NLC formulation was designed by melt-emulsification ultrasonication technique, by fluctuating the concentration of stearic acid and oleic acid. Poloxamer F68 and tween 80 were used as surfactants in the formulation and soya lecithin was used as stabilizer and co-surfactant. Differential scanning calorimetry (DLS), scanning electron microscopic studies (SEM), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), x-ray diffraction (XRD), are the techniques used to characterize the preparations. Optimized drug-loaded formulations were evaluated for particle size, zeta potential, entrapment efficiency, in vitro drug release, hemocompatibility assay and cytotoxicity screening.
Results: For drug loaded formulation the particle size was found in nanometric range. In vitro drug release was carried out using dialysis membrane and drug release after 24h was found to be 90.98 %Â±1.89 for CP and 79.81 %Â±4.20 for PH.
Conclusion: The formulated NLC is a potential approach for sustained release of drug which may reduce systemic side effects, increase skin retention time and duration of action. Further in vivo studies will confirm the effect of NLC to increase skin retention time, decreases systemic absorption of the corticosteroid thereby avoiding side effects.
EVALUATION OF DIFFERENT SYNTHETIC AND NATURAL POLYMERS AS PROTECTIVE LAYER ON HIGHLY SOLUBLE AND HIGH DOSE DRUG METOPROLOL SUCCINATEFOR MANUFACTURING OF CONTROL RELEASE MULTI UNIT PELLETS TABLETS
Authors: Borra Syam Prasad , Eswaraiah M. Chenna , Reddy G. Kamalakar 
Published: May 2023

Objective: Evaluation of different natural and synthetic polymers as protective layer (PL) in the manufacturing of control release (CR) multi-unit pellets (MUPS) tablets, highly soluble and high dose drug metoprolol succinate (MS) was selected as model drug. The function of PL is to protect CR functional coating layer of pellets from damage during compression of MUPS tablets.Â Methods: MS is highly soluble biopharmaceutics classification system(BCS) Classâ€“I molecule, hence selected aqueous solution layering method for drug loading in fluid bed processor (FBP), optimized formulation was manufactured by using seal coating on microcrystalline cellulose (MCC) pellets followed by drug loading (DL) and CR coating, applied by using the solution layering method in FBP. Given coating on these functional coated pellets with different natural and synthetic polymers like hydroxypropyl cellulose (Klucel LF), polyethylene glycol 6000 (PEG 6000), hypromellose 5 cps (HPMC 5cps), guar gum (GG) and xanthan gum (XM). Evaluated these pellet's for physical characterization and chemical characterization.Results: Drug release profiles of CR MUPS tablets containing PL coating were compared to those CR pellets and f2 values observed was 81.83, 49.92, 89.35, 66.44, and 85.25 with Klucel LF, PEG 6000, HPMC 5 cps, GG and XM coated MUPS tablets respectively. The dissolution data indicated that, there was no significant change were observed with MUPS containing Klucel LF, HPMC 5 cps, GG and XG PLs whereas faster release profiles were observed with PEG 6000PL MUPS tablets.Conclusion: Based on these dissolution profiles it was concluded that by applying low viscous natural or synthetic binders like Klucel LF, HPMC 5 cps, GG and XG on functional coating pellets given good protection to functional coating pellets from damage during compression. It is a very effective and potent strategy for manufacturing of MUPS tablets. Whereas PEG 6000 polymer not able to give protection to functional coating pellets from damage during compression, it may be due to its very low viscosity of PEG 6000.
Appraising the Roles of Head Teachers in Maintenance of Classroom Physical Facilities in Osun State Primary Schools, Nigeria
Authors: Olowo Busuyi Francis 
Published: May 2023

Head teachers’ roles are indispensable in managing and maintaining classroom physical facilities. Maintenance of available classroom physical facilities is very significant in every school. This paper examined the roles of head teachers in maintaining classroom physical facilities in Osun State primary schools. The study adopted a descriptive research design. The study population consisted of all 9,870 teachers in Osun State primary schools. The sample comprised 385 teachers who were selected using simple random sampling techniques. Appraising the roles of Head Teachers’ Maintenance of Classroom Facilities Questionnaire (AHMCFQ) was the instrument used for data collection. Data were analyzed descriptively. The results showed that the present condition of the classrooms environment was conducive for pupils to learn (M = 3.23), the aesthetic of the classrooms environment encouraged the pupils to come to school (M = 3.13), each of the pupils has confortable chair and table in their various classes ( M = 3.18) and the classrooms were located in an area that saved from dangers (M = 3.30). The findings equally showed that the head teachers in Osun State primary schools ensured that the classrooms’ surroundings were neat and clean daily (M = 3.61 through assigning teachers to supervise the cleanliness of the classrooms in their section (M = 3.43)), inspected the classrooms facilities daily to ascertain their condition (M = 3.39) maintained classrooms surroundings by planting flowers and trees to provide shades (M = 2.87) and replaced worn out classrooms facilities using internally generated revenue (M = 2.70). However, the study further regarded financial constraints (M = 2.83) and misuse of the facilities by pupils (M = 2.52) as challenges encountered by head teachers in maintaining available physical facilities in Osun State primary schools. The study concluded that the head teachers significantly contributed to improving the present condition of classroom physical facilities. The findings implicate that the head teachers should accept the maintenance of classroom physical facilities as their responsibility and they should devise skills to make it in good shape to use.
Pluralism and Equality in the Perspective of Human Rights in Indonesia
Authors: Abustan  
Published: May 2023

Abstract
In the context of Indonesia's plural society, where the demand for pluralism is increasingly urgent during the democratic transition, it often raises questions about how the implementation of the principle of equality can be the foundation of democracy and the fulfillment of human rights. The purpose of writing is to analyzehow society respects pluralism/equality as part of the fulfillment of citizens' rights in a democratic country. The research method used is normative juridical by referring to legal norms contained in the constitution and legislation. The aim of the research is to identify the important dimensions that the state must consider in realizing pluralism and equality from the perspective of human rights in Indonesia. Moreover, it aims to demonstrate that in a diverse society, religious tolerance in the effort of developing religious life can still run harmoniously, dialogically, and tolerantly in the present modern Indonesia era. This is especially important for Indonesia, as it has the fourth-largest population in the world. Therefore, the presence of the state in supporting the multicultural democratic society is highly needed.
Keywords: Plurality and Equality; Human Rights; and Democracy.
Abstrak
Dalam konteks masyarakat Indonesia yang plural, di mana tuntutan akan paham kemajemukan semakin mendesak pada masa transisi demokratisasi, sehingga kerap kali mengimbulkan pertanyaan bagaimana penerapan prinsip kesetaraan dapat menjadi landasan perjuangan demokrasi dan pemenuhan hak asasi manusia. Pertanyaan tersebut itulah yang menjadi fokus riset ini, yakni meneliti tentang bagaimana tatanan masyarakat menghormati kemajemukan/kesetaraan sebagai bagian dari pemenuhan hak-hak warga negara dalam sebuah negara demokrasi. Metode penelitian ini menggunakan metode Yuridis Normatif yaitu dengan mengacu pada norma-norma hukum yang terdapat dalam konstitusi dan peraturan perundang-undangan. Tujuan penelitian mengetahui dimensi-dimensi penting yang menjadi perhatian negara dalam mewujudkan kemajemukan dan kesetaraan dalam perspektif hak asasi manusia di Indonesia. Lebih dari itu, juga hendak menunjukkan bahwa dalam ranah masyarakat majemuk, toleransi agama dalam upaya pengembangan kehidupan beragama tetap berjalan harmonis, dialogis, dan toleran dalam era Indonesia moderen sekarang ini. Apalagi Negara Indonesia dengan jumlah populasi penduduk terbesar ke 4 di dunia. Maka dari itu, kehadiran negara dalam rangka menopang pilar masyarakat demokratis multikultural sangat diperlukan.
Kata kunci: Kemajemukan dan Kesetaraan, Hak Asasi Manusia dan Demokrasi.
DiasMorph: a dataset of morphological traits and images of Central European diaspores
Authors: Dayrell Roberta L. C. , Begemann Lina , Ott Tankred , Poschlod Peter 
Published: May 2023

A knowledge of the morphology of seeds and diaspores is an invaluable
resource that has prompted the compilation of descriptions and/or images
in a variety of media, including databases with standardized protocols
for trait measurement. The pressing need for new solutions to solve
environmental crises, together with advances in the application of
machine learning and image analysis to solve ecological problems, call
for an upgrade of the diaspore morphological datasets. Here, we present
DiasMorph, a dataset of morphological traits and images of diaspores
from 1,437 taxa in 513 genera, and 96 families from Central Europe,
totalling 94,214 records. DiasMorph compiles information on quantitative
morphological traits extracted from the images following a standardized
and reproducible image analysis method, and include not only traditional
morphometric measurements, but also colour, and shape features made
available for the first time in a large dataset. The quantitative traits
records correspond to measurements of individual diaspores, an input
currently unavailable in traits databases that will allow for several
approaches to be used for a complete exploration of the morphological
traits of these species. We also included information on the presence
and absence of appendages and structures in the diaspores of the
evaluated taxa. By making these data available, we aim to encourage
initiatives to advance on new tools for diaspore identification, further
our understanding of morphological traits functions, and provide means
for the continuous development of image analyses applications.
Keywords: diaspore appendages, dispersal unit, image dataset,
plant traits dataset, seed colour, seed morphology, seed shape, seed
size, seed traits.
DISTINCT INSULIN PHYSIOLOGY TRAJECTORIES IN EUGLYCEMIC PREGNANCY AND GESTATIONAL DIABETES MELLITUS
Authors: Thaweethai Tanayott , Soetan Zainab , James Kaitlyn , Florez Jose C. , Powe Camille E. 
Published: May 2023

<p> </p>
<p>Objective: To evaluate changes in insulin physiology in euglycemic pregnancy and gestational diabetes (GDM).</p>
<p>Research Design and Methods: Participants underwent oral glucose tolerance tests at ≤15 weeks’ gestation (early), 24-32 weeks’ gestation (mid-late), and 6-24 weeks postpartum. We evaluated longitudinal changes in insulin secretory response (log Stumvoll first-phase estimate) and insulin sensitivity (log Matsuda index) using linear mixed models. We then evaluated participants who met GDM criteria in early pregnancy (early GDM) and mid-late pregnancy (classic GDM) separately from those without GDM. We derived the Pregnancy Insulin Physiology (PIP) index to quantify beta-cell compensation for insulin resistance.</p>
<p>Results: Among 166 participants, 21 had early GDM and 24 developed classic GDM. Insulin sensitivity was reduced slightly in early (β=-0.20, p<0.001) and substantially in mid-late pregnancy (β=-0.47, p<0.001) compared to postpartum. Insulin secretory response (adjusted for insulin sensitivity) was augmented in early (β=0.16, p<0.001) and mid-late (β=0.16, p=0.001) pregnancy compared to postpartum. Compared to postpartum, the PIP index was augmented in early (β=215, p=0.04) but not mid-late (β=55, p=0.64) pregnancy. Early GDM was distinguished by a substantial reduction in insulin sensitivity in early pregnancy (β=-0.59, p<0.001) compared to postpartum. Both early and classic GDM lacked evidence of early pregnancy augmentation of insulin secretory response (adjusted for insulin sensitivity) and the PIP index (p>0.1 versus postpartum). Early pregnancy PIP index predicted GDM, independent of participant characteristics (AUC without PIP: 0.70 95% CI [0.61-0.79], AUC with PIP: 0.87 [0.80-0.93]).</p>
<p>Conclusions: Beta-cell function is enhanced in early pregnancy. Deficient first trimester beta-cell function predicts GDM.<br>
</p>
Influencing Factors of K-Drama Satisfaction and their Impacts on Fanaticism and Behavioral Intention
Authors: Sukendi Jacinda , Siregar Randi Kosim , Wansaga Susi Cristhyn , Gunadi Willy 
Published: May 2023

The goal of this research was to identify factors that affect K-drama satisfaction from the perspectives of attractiveness, credibility, connectedness, involvement, and commitment variables and their impacts on fanaticism and behavioral intention. Data were obtained through an online questionnaire given to Indonesian in Jakarta who were at least 17 years old and had seen at least one K-drama title with at least twelve episodes. This research used 266 samples, and the data were analyzed by applying the Partial Least Squares-Structural Equation Model (PLS-SEM). Results show that (1) attractiveness, credibility and involvement have a significant positive influence on drama satisfaction, (2) drama satisfaction has a significant positive influence on both fanaticism and behavioral intention, and (3) fanaticism has a significant positive influence on behavioral intention. Furthermore, results also find that connectedness has a significant negative influence on drama satisfaction, whereas commitment has an insignificant negative influence.
CONCEPTUAL LEARNING MODEL WITH MARIND CULTURE BASED FOR ELEMENTARY SCHOOL IN KAIBURSE MERAUKE
Authors: Leba Seli Marlina Radja , Mayasari Dian , Natsir Irmawaty 
Published: May 2023

Each region has a cultural heritage that has been passed down for generations, even in areas within one country have various kinds of cultural heritage. One of the areas in Indonesia that has a cultural heritage is Merauke Regency which is inhabited by the Malind Tribe. This study aims to apply real experiences that can be found in the Malind (Papua) tribe as material in curriculum development that can be applied in the South Papua region. This research was conducted in a village located in Kaiburse, Merauke Regency, which is inhabited by the Malind people. This research is a descriptive research with a qualitative approach. Researchers continuously participate actively in the field by recording and analyzing and representing all findings found in the field. The approach used in order to analyze in depth all forms of cultural heritage values found in the indigenous people of the Marind tribe who inhabit Kaiburse Village. The real experience gained based on the results of observations, interviews in the field and documentation during the research that is then carried out is data triangulation. This research produces an explanation of local wisdom in mathematics material. This research can be the main source of the government to integrate local wisdom in learning in schools
THE DEVELOPMENT GEMATIKA AS A WEBSITE-BASED MATHEMATICS LEARNING MEDIA ON COMPARISON MATERIALS
Authors: Makmur Firdayana , Andayani Sri , Sufaidah Vevi Arini Azizatus 
Published: May 2023

Technology-based learning media in the learning process must be applied in today's digital era. GEMATIKA as website-based mathematics learning media was developed to support students' mathematics learning, especially Comparative material. This study aims to determine the process of developing learning media based on the GEMATIKA website that meets valid and practical criteria. This type of research is development research using the ADDIE development model. Data was collected using material and media expert validation sheets and student response questionnaires to the GEMATIKA website learning media. The subjects of this study consisted of 28 students from class VII. The results showed that the results of media validation by material experts and media experts were 4.13 and 4.29. The average percentage of student response questionnaire results is 80.82%. It means that students respond positively after using the GEMATIKA learning media. The positive responses indicate that students support, feel happy, and are interested in using the GEMATIKA website learning media in the mathematics learning process at home or in class. Based on the results of the validation sheet and student response questionnaires, it can be concluded that the GEMATIKA website learning media meets the valid and practical criteria