bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous determination of multiple constituents, serum composition, and tissue distribution of Qingshen granule using ultra‐high performance liquid chromatography‐quadrupole‐orbitrap high‐resolution mass spectrometry
Authors: Dai Rong , Lu Jin‐yuan , Chen Wei‐dong , Hong Bang‐zhen , Zhang Lei , Cheng Meng , Wang Yi‐ping , Zhang Yue 
Published: August 2023

Qingshen granule, composed of 14 herbal drugs, is primarily used as the assistant therapy for chronic kidney disease. Qingshen granule chemical composition was complex, but its chemical constituents and the pharmacodynamic material basis remain unreported. Ultra‐high‐performance liquid chromatography (UHPLC)‐quadrupole‐orbitrap high‐resolution mass spectrometry was applied to recognize the chemical constituents of Qingshen granule. The analysis was performed using the ACQUITY UHPLC BEH C18 column (2.1 × 50 mm, 1.7 μm) with acetonitrile‐0.1% formic acid as the mobile phase for gradient elution. The data were collected using heated electrospray ionization in positive and negative ion modes. This study successfully applied the UPHLC‐quadrupole‐orbitrap high‐resolution mass spectrometry technique with the Compound Discoverer 3.3 platform to analyze Qingshen granule chemical composition. A total of 127 and 42 chemical components were identified in Qingshen granule in vitro and in vivo, respectively. In the tissue distribution of Qingshen granule, 9, 10, 11, 10, and 18 prototype components were detected in the heart, liver, spleen, lungs, and kidneys, respectively. Qingshen granule chemical constituents were characterized rapidly for the first time in this study, laying a foundation for further research on the substance basis and quality control of Qingshen granule in treating chronic kidney disease.
Exacerbation of inflammatory disseminated superficial porokeratosis following COVID‐19 vaccination
Authors: Ishikawa Tomomu , Asai Jun , katoh Norito 
Published: August 2023

AbstractThe mRNA‐1273 vaccine for coronavirus disease (COVID‐19) authorised as one of the first COVID‐19 vaccines was released by Moderna in December 2020. A recent study indicates that messenger RNA (mRNA) vaccines appear to be effective in preventing aggravation, hospitalisation and death against COVID‐19 infection. However several adverse effects have been reported. Of these, the dermatological adverse effects are relatively rare entities Herein, we present a case of inflammatory disseminated superficial porokeratosis exacerbated after administration of the fourth dose of the mRNA‐1273 vaccine.
Breast tissue analysis using a clinically compatible combined time‐resolved fluorescence and diffuse reflectance (TRF‐DR) system
Authors: Dao Erica , Gohla Gabriela , Williams Phillip , Lovrics Peter , Badr Fares , Fang Qiyin , Farrell Thomas , Farquharson Michael 
Published: August 2023

AbstractObjectiveThis work aims to develop a clinically compatible system that can perform breast tissue analysis in a more time efficient process than conventional histopathological assessment. The potential for such a system to be used in vivo in the operating room or surgical suite to improve patient outcome is investigated.MethodIn this work, 80 matched pairs of invasive ductal carcinoma and adjacent normal breast tissue were measured in a combined time‐resolved fluorescence and diffuse reflectance (DA) system. Following measurement, the fluorescence intensity of collagen and flavin adenine dinucleotide (FAD); the fluorescence lifetime of collagen, nicotinamide adenine dinucleotide (NADH), and FAD; the DA; absorption coefficient; and reduced scattering coefficient were extracted. Samples then underwent histological processing and H&E staining to classify composition as tumor, fibroglandular, and/or adipose tissue.ResultsStatistically significant differences in the collagen and FAD fluorescence intensity, collagen and FAD fluorescence lifetime, DA, and scattering coefficient were found between each tissue group. The NADH fluorescence lifetime and absorption coefficient were statistically different between the tumor and fibroglandular groups, and the tumor and adipose groups. While many breast tissue analysis studies label fibroglandular and adipose together as “normal” breast tissue, this work indicates that some differences between tumor and fibroglandular tissue are not the same as differences between tumor and adipose tissue. Observations of the reduced scatter coefficient may also indicate further classification to include fibro‐adipose may be necessary. Future work would benefit from the additional tissue classification.ConclusionWith observable differences in optical parameters between the three tissue types, this system shows promise as a breast analysis tool in a clinical setting. With further work involving samples of mixed composition, this combined system could potentially be used intraoperatively for rapid margin assessment.
Characterization and Selection of Tailorable Heat Triggered Epoxy Shape Memory Polymers for Epoxy Debondable Adhesives
Authors: Istiak Asif , Lee Hak Gu , Hwang Hui Yun 
Published: August 2023

AbstractThe increasing concern for environmental and economic sustainability has resulted in a growing interest in recycling the hybrid structures used in modern industries. To address the challenge of easy separation without damaging the substrates, a debondable‐adhesive incorporating shape memory polymer (SMP) filler is proposed. This study synthesizes seven types of epoxy SMPs at different stoichiometric ratios of the same chemicals. The thermomechanical, mechanical, and recovery characteristics of the SMPs are evaluated, and the most suitable candidate for debondable‐adhesive application is selected based on the selection criteria of SMP for embedding in the debondable adhesive. The results of this study offer valuable insights into the potential SMPs which can be incorporated in debondable adhesives used in modern industries.
Forcing revisited
Authors: Meadows Toby 
Published: August 2023

AbstractThe purpose of this paper is to propose and explore a general framework within which a wide variety of model construction techniques from contemporary set theory can be subsumed. Taking our inspiration from presheaf constructions in category theory and Boolean ultrapowers, we will show that generic extensions, ultrapowers, extenders and generic ultrapowers can be construed as examples of a single model construction technique. In particular, we will show that Łoś's theorem can be construed as a specific case of Cohen's truth lemma, and we isolate the weakest conditions a filter must satisfy in order for the truth lemma to work.
Inorganic nanoparticle‐integrated mesenchymal stem cells: A potential biological agent for multifaceted applications
Authors: Zheng Juan‐Juan , Jiang Xin‐Chi , Li Yao‐Sheng , Gao Jian‐Qing 
Published: August 2023

AbstractMesenchymal stem cell (MSC)‐based therapies are flourishing. MSCs could be used as potential therapeutic agents for regenerative medicine due to their own repair function. Meanwhile, the natural predisposition toward inflammation or injury sites makes them promising carriers for targeted drug delivery. Inorganic nanoparticles (INPs) are greatly favored for their unique properties and potential applications in biomedical fields. Current research has integrated INPs with MSCs to enhance their regenerative or antitumor functions. This model also allows the in vivo fate tracking of MSCs in multiple imaging modalities, as many INPs are also excellent contrast agents. Thus, INP‐integrated MSCs would be a multifunctional biologic agent with great potential. In this review, the current roles performed by the integration of INPs with MSCs, including (i) enhancing their repair and regeneration capacity via the improvement of migration, survival, paracrine, or differentiation properties, (ii) empowering tumor‐killing ability through agent loaded or hyperthermia, and (iii) conferring traceability are summarized. An introduction of INP‐integrated MSCs for simultaneous treatment and tracking is also included. The promising applications of INP‐integrated MSCs in future treatments are emphasized and the challenges to their clinical translation are discussed.
Initial feasibility and challenges of hyperpolarized 129Xe MRI in neonates with bronchopulmonary dysplasia
Authors: Stewart Neil J. , Higano Nara S. , Mukthapuram Shanmukha , Willmering Matthew M. , Loew Wolfgang , West Michael , Arnsperger Anita , Pratt Ronald , Rao Madhwesha R. , Schulte Rolf F. , Wild Jim M. , Woods Jason C. 
Published: August 2023

AbstractPurposeThe underlying functional and microstructural lung disease in neonates who are born preterm (bronchopulmonary dysplasia, BPD) remains poorly characterized. Moreover, there is a lack of suitable techniques to reliably assess lung function in this population. Here, we report our preliminary experience with hyperpolarized 129Xe MRI in neonates with BPD.MethodsNeonatal intensive care patients with established BPD were recruited (N = 9) and imaged at a corrected gestational age of median:40.7 (range:37.1, 44.4) wk using a 1.5T neonatal scanner. 2D 129Xe ventilation and diffusion‐weighted images and dissolved phase spectroscopy were acquired, alongside 1H 3D radial UTE. 129Xe images were acquired during a series of short apneic breath‐holds (˜3 s). 1H UTE images were acquired during tidal breathing. Ventilation defects were manually identified and qualitatively compared to lung structures on UTE. ADCs were calculated on a voxel‐wise basis. The signal ratio of the 129Xe red blood cell (RBC) and tissue membrane (M) resonances from spectroscopy was determined.ResultsSpiral‐based 129Xe ventilation imaging showed good image quality and sufficient sensitivity to detect mild ventilation abnormalities in patients with BPD. 129Xe ADC values were elevated above that expected given healthy data in older children and adults (median:0.046 [range:0.041, 0.064] cm2s−1); the highest value obtained from an extremely pre‐term patient. 129Xe spectroscopy revealed a low RBC/M ratio (0.14 [0.06, 0.21]).ConclusionWe have demonstrated initial feasibility of 129Xe lung MRI in neonates. With further data, the technique may help guide management of infant lung diseases in the neonatal period and beyond.
NMR metabolomics study of chronic low‐dose exposure to a cocktail of persistent organic pollutants
Authors: Lucas‐Torres Covadonga , Caradeuc Cédric , Prieur Laura , Djemai Haidar , Youssef Layale , Noirez Philippe , Coumoul Xavier , Audouze Karine , Giraud Nicolas , Bertho Gildas 
Published: August 2023

AbstractNowadays, exposure to endocrine‐disrupting chemicals (EDCs), including persistent organic pollutants (POPs), is one of the most critical threats to public health. EDCs are chemicals that mimic, block, or interfere with hormones in the body's endocrine system and have been associated with a wide range of health issues. This innovative, untargeted metabolomics study investigates chronic low‐dose internal exposure to a cocktail of POPs on multiple tissues that are known to accumulate these lipophilic compounds. Interestingly, the metabolic response differs among selected tissues/organs in mice. In the liver, we observed a dynamic effect according to the exposure time and the doses of POPs. In the brain tissue, the situation is the opposite, leading to the conclusion that the presence of POPs immediately gives a saturated effect that is independent of the dose and the duration of exposure studied. By contrast, for the adipose tissues, nearly no effect is observed. This metabolic profiling leads to a holistic and dynamic overview of the main metabolic pathways impacted in lipophilic tissues by a cocktail of POPs.
Seeing is believing: A qualitative study examining how high and ultra‐high‐net‐worth donors utilise evidence to inform their giving and the barriers to and facilitators of the use of evidence
Authors: Greenhalgh Caroline , Montgomery Paul 
Published: August 2023

AbstractWhilst there is growing recognition across the non‐profit literature, that the giving of resources ought to be informed by rigorous evidence, few studies to date have examined how high and ultra‐high‐net‐worth donors use evidence to inform their philanthropy, the type and quality of the evidence they utilise, and how they measure the performance of the charities they support. The primary objective of this study was to examine whether and how philanthropists employ evidence to inform their decision‐making. We employed in‐depth qualitative research methods to elicit the perspectives of philanthropists on how they engaged with evidence and, in so doing, filled a gap in the data. We found barriers to utilising evidence included challenges in accessing evidence, difficulties in assessing the quality and appropriateness of evidence and insufficient resources to capture evidence. Facilitators of evidence use included: making evidence more accessible and enhanced access to professional philanthropy advice and advisors. Despite growing awareness of the importance of evidence, few donors employed sound evidence‐based models of philanthropy.
Shortened fetal long bones: A notable intrauterine phenotypic feature in SHOX‐associated skeletal dysplasia
Authors: Hu Rong , Huang Weiwei , Ren Congmian , Liu Ling , Hou Yaping , Wang Yunan , Lu Jian 
Published: August 2023

AbstractObjectiveTo explore the intrauterine phenotypic spectrum of short stature homeobox‐containing (SHOX) gene‐associated skeletal dysplasia and provide genetic counseling at‐risk pregnancies.MethodWe analyzed the fetuses with SHOX‐microdeletions identified by single nucleotide polymorphism (SNP)‐array. The intrauterine phenotypes and outcomes were further elaborated.ResultsNine fetuses carrying a single SHOX‐microdeletion were reported, with deletion sizes ranging from 0.134 to 1.35 Mb. Shortened long bones were observed in all fetuses, varying from −2.0 standard deviation (SD) to −5.3 SD. Moreover, all cases had a femur length/foot ratio less than 0.87 and a femur/abdominal circumference ratio greater than 0.16, suggesting that non‐lethal skeletal dysplasia may be involved. Two fetuses showed intrauterine growth restriction, and two had nasal bone hypoplasia. Prenatal ultrasonography did not reveal other obvious anomalies, including the Madelung deformity. Five microdeletions were inherited and one was de novo. Five terminations and four newborns were recorded. Two newborns had normal stature, and two were short‐statured (height <3rd percentile), with one having inflexible wrists.ConclusionsSHOX haploinsufficiency may manifest with shortened fetal long bones. The combination of history taking, prenatal ultrasonography, and SNP‐array can prompt early prenatal diagnosis and timely postnatal treatment of SHOX‐associated skeletal dysplasia.
Monosaccharide‐Directed Selective Internalization of Gold and Silver Nanoparticles in Hepatic Cancer Cells
Authors: Bhagat Stuti , Tyagi Simona , Singh Sanjay 
Published: August 2023

AbstractThe therapeutic success of nanomedicines requires nanomaterials to either adhere to the surface or internalize within the cytoplasm. The endocytosis phenomenon is controlled by the nanomaterial's shape, size, composition, charge, and capping molecules. The membrane potential‐based non‐specific internalization of therapeutic nanomedicines offers limited benefits than receptor‐based specific delivery. Glut receptor‐based internalization of glucose molecules is a well‐known process in cancerous cells, which is one of the most exploited strategies to target cancer cells using nanoparticles. However, the internalization process of other structurally similar monosaccharides (D‐Galactose, Mannose, and D‐Fructose) conjugated nanoparticles remains to be unexplored. Herein, D‐Glucose, D‐Galactose, Mannose, and D‐Fructose‐coated AuNPs and AgNPs have been synthesized and studied the role of Glut receptors in their internalization in liver cancer cells, and compared them with non‐cancerous cells. Results revealed that almost all monosaccharide‐coated NPs exhibited high uptake in liver cancer cells than non‐cancerous cells. Glut‐1 receptor is observed to play a key role in the uptake and inhibition of Glut‐1 receptors by genistein lead to a significant decrease in nanoparticle uptake. In conclusion, monosaccharide‐conjugated nanoparticles can be used to direct the selective internalization of AuNPs and AgNPs in hepatic cancer cells to realize therapeutic and imaging applications.
Avoiding water hammer and other hydraulic transients
Authors: Britton Laurence G. , Willey Ronald J. 
Published: August 2023

AbstractWater hammer may occur upon rapidly closing a water pipe valve. Oscillating pressure waves generated in the system may cause significant equipment damage, including joint leaks and even pipe rupture. Similar phenomena can occur when starting and stopping pumps. As various situations can cause potentially damaging pressure waves, water hammer and related phenomena are grouped as “hydraulic transients.” The phenomena are not limited to water pipes and may occur in any liquid, including condensed gases such as chlorine, ammonia, and liquefied natural gas (LNG). Hydraulic transients deserve more coverage in college courses and textbooks on process safety, while at an industrial level, the topic should be considered in design and hazard reviews. This article provides a brief introduction to the topic with a focus on mitigation methods. Available options should be evaluated during the design process rather than applied retroactively after a problem becomes evident.
Back Cover Image
Authors: Song Yifei , Yang Xianming , Li Hui , Wu Kongming 
Published: August 2023

The back cover image is based on the Research Article The invasive Spodoptera frugiperda (J.E. Smith) has displaced Ostrinia furnacalis (Guenée) as the dominant maize pest in the border area of southwestern China by Yifei Song et al., https://doi.org/10.1002/ps.7524.
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Packaging innovation scorecard
Authors: Pålsson Henrik , Hellström Daniel 
Published: August 2023

AbstractInnovation literature shows that the characteristics of a company's innovation processes determine their performance in different areas. In this study, we adopt a general conceptual model from innovation theory and apply it to packaging innovation. This helps identify and describe subprocesses in packaging innovation and how to measure their performance. It also links the packaging innovation process to the cost and climate performance of packaging. Based on the modified model for packaging innovation, the purpose of this paper is to develop and apply a scorecard for assessing the packaging innovation process.The first step in the methodology was the conceptual development of a model describing the packaging innovation process and a scorecard for assessing this process. The second step was to demonstrate and validate the scorecard in a case study covering packaging innovation at a major retail company. Data were captured from six semi‐structured interviews and two workshops, as well as observations and site visits.The conceptual model defines packaging innovation using seven interrelated subprocesses and their impacts on cost and climate performance. The scorecard that was developed in the research study describes how to measure the subprocesses and their output. The quality of each of the seven processes is measured on two to four dimensions. Each dimension can reach a score of one to four, where each score is clearly defined.The case study showed that the scorecard seems to be an effective way of measuring the complex packaging innovation process and identifying concrete ways to improve packaging innovation. The case study validated the scorecard and demonstrated how it can be applied. The application also showed how the case company performs in packaging innovation compared to best practice in each subprocess. The validation showed that the scorecard is sufficiently functional and useful, although it requires input from multiple sources. The usability could only be partly assessed—it showed promising value as a basis for formulating action plans—but future studies should validate the scorecard's long‐term usefulness in creating action plans and assess their impact.The theoretically‐based scorecard is novel in terms of assessing packaging innovation and its impact on packaging performance in supply chains. It links the packaging innovation process to performance and helps companies identify improvement possibilities. The paper shows how the scorecard helps address packaging issues strategically by measuring the activities conducted in the packaging innovation process. One limitation of the study is that the long‐term usefulness of the scorecard could not be validated, as the validation would take longer than the time available for this study.
A case of primary lung cancer requiring differentiation from metastatic cervical cancer
Authors: Kataoka Yoko , Fujita Takuya , Fukunaga Kentaro , Hanaoka Jun 
Published: August 2023

Abstractp16 has been used as a surrogate marker for human papillomavirus (HPV)‐related tumours. However, it remains unclear whether p16 is also a potential marker for pulmonary tumours. Herein, we report the case of an 80‐year‐old woman with a history of papillary squamous cell carcinoma of the uterine cervix, presenting with a left pulmonary tumour. A bronchoscopic biopsy revealed squamous cell carcinoma with a papillary pattern, which did not rule out pulmonary metastasis from the cervix. Immunohistochemical staining revealed that the cervical tumour was positive for p16, whereas the pulmonary tumour was negative and was effectively diagnosed as primary pulmonary carcinoma.
Climate adaptation in informal areas in hot arid climates
Authors: Lotfata Aynaz , Cortesão João , Zinsmeister Hestia , Steeneveld Gert‐Jan , van Zeben Josephine , Taylor Zac , Tan Wendy , Elkhateeb Samah 
Published: August 2023

AbstractThis conceptual and exploratory research study investigates, systematically and holistically, climate‐adaptive spatial design interventions for high‐density informal urban areas in hot arid climates, which remain understudied despite their vulnerability to heat stress and the heat‐vulnerable groups populating them. Five streetscape design prototypes are proposed that include climate‐adaptive spatial interventions appraised qualitatively with consideration to relevant feasibility matters: land use planning, equity, affordability, mobility, and sense of place. The study shows that there is potential for climate‐adaptive interventions in informal urban areas in hot arid climates, but that these interventions also present challenges. Common climate‐adaptive design strategies can be used to address heat stress in these areas but, for example, increasing vegetation might be challenging due to water stress. As a conceptual study, the findings presented and the discussion raised on feasibility are targeted at opening avenues for future research, and at informing decision‐makers and spatial designers.