bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual angiotensin receptor and neprilysin inhibitor reduced portal pressure through peripheral vasodilatation and decreasing systemic arterial pressure in cirrhotic rats
Authors: Pun Chon Kit , Chang Ching-Chih , Chuang Chiao-Lin , Huang Hui-Chun , Hsu Shao-Jung , Huang Yi-Hsiang , Hou Ming-Chih , Lee Fa-Yauh 
Published: July 2023

Background:
Portal hypertension develops along with the progression of liver cirrhosis. Natriuretic peptides have been shown to reduce portal pressure but concomitantly activate the renin-angiotensin-aldosterone system (RAAS). Angiotensin receptor-neprilysin inhibitors (ARNIs) upregulate natriuretic peptides and avoid the adverse effects of RAAS activation. ARNIs have been shown to reduce portal pressure in rats with pre-hepatic portal hypertension, which involves relatively little liver injury. This study aimed to evaluate the relevant effects of an ARNI in rats with both liver cirrhosis and portal hypertension.

Methods:
Male Sprague-Dawley rats received common bile duct ligation to induce liver cirrhosis and portal hypertension. Sham-operated rats served as surgical controls. All rats were randomly allocated into three groups to receive distilled water (vehicle), LCZ696 (an ARNI), or valsartan for 4 weeks. Portal hypertension and relevant derangements were assessed after treatment.

Results:
Portal hypertension and hyperdynamic circulation developed in the cirrhotic rats. In the rats with cirrhosis and portal hypertension, both LCZ696 and valsartan reduced portal hypertension, mean arterial pressure, and systemic vascular resistance. The decrease in portal pressure was highly associated with the reduction in arterial pressure and systemic vascular resistance. Blood flow in hepatic, splanchnic, and portosystemic collateral systems was not altered. LCZ696 did not significantly influence liver injury or plasma cytokine levels. Liver fibrosis and splanchnic angiogenesis were not affected.

Conclusion:
ARNI treatment exerted portal pressure lowering effects via peripheral vasodilatation and decreasing systemic arterial pressure in the rats with liver cirrhosis and portal hypertension. Caution should be taken when using ARNIs in liver cirrhosis.
Minimally invasive surgery versus laparotomy of non-metastatic pT4a colorectal cancer: a propensity score analysis
Authors: Guo Hui-Long , Chen Jing-Yao , Tang You-Zhen , Zeng Qian-Lin , Jian Qing-Long , Li Ming-Zhe , He Yu-Long , Wu Wen-Hui 
Published: July 2023

Aim:
To compare short- and long-term oncological outcomes between minimally invasive surgery (MIS group) and laparotomy (lap group) in non-metastatic pT4a colorectal cancer (CRC).

Materials and Methods:
The study retrospectively analyzed outcomes of 634 patients treated with radical operation from January 2015 to December 2021 for non-metastatic pT4a CRC, with propensity score matching.

Results:
Conversion rate from minimally invasive surgery group to laparotomy is 3.5%. Intraoperative blood loss, time to first anal exhaust, defecation and drainage tube removal, and complication rate were significantly less in the minimally invasive surgery group. After 5 years, the outcomes of MIS group were no inferior to laparotomy outcomes (overall survival: 72.7% vs. 77.8%, P=0.285; disease-free survival: 72.2% vs. 75.0%, P=0.599). And multivariate analysis showed that age ≥60 years old, lymph node metastasis and the CEA levels were independent variables for OS, while lymph node metastasis and CA125 levels were independent variables for DFS. The results of the graph show the relationship between the sum of scores of gender, age, complications, BMI, CEA, age, CA125, tumor site, N stage and tumor length diameter and 1-year, 3-year and 5-year mortality and disease-free survival of patients. Among them, tumor length diameter and N stage are significantly correlated with long-term survival and disease-free of patients.

Conclusion:
Minimally invasive surgery is safe and feasible for non-metastatic pT4a CRC, with the added benefit of accelerated post-operative recovery. In oncology, minimally invasive surgery did not affect overall survival and disease-free survival.
mRNA vaccines against respiratory viruses
Authors: Whitaker Jennifer A. , Sahly Hana M. El , Healy C. Mary 
Published: July 2023

Purpose of review
The successes of the coronavirus disease 2019 (COVID-19) mRNA vaccines have accelerated the development of mRNA vaccines against other respiratory pathogens. The aim of this review is to highlight COVID-19 mRNA vaccine advances and provide an update on the progress of mRNA vaccine development against other respiratory pathogens.

Recent findings
The COVID-19 mRNA vaccines demonstrated effectiveness in preventing severe COVID-19 and death. H7N9 and H10N8 avian influenza mRNA vaccines have demonstrated safety and immunogenicity in phase 1 clinical trials. Numerous seasonal influenza mRNA vaccines are in phase 1–3 clinical trials. Respiratory syncytial virus (RSV) mRNA vaccines have progressed to phase 2–3 clinical trials in adults and a phase 1 clinical trial in children. A combined human metapneumovirus and parainfluenza-3 mRNA vaccines was found to be well tolerated and immunogenic in a phase 1 trial among adults and trials are being conducted among children. Clinical trials of mRNA vaccines combining antigens from multiple respiratory viruses are underway.

Summary
The development of mRNA vaccines against respiratory viruses has progressed rapidly in recent years. Promising vaccine candidates are moving through the clinical development pathway to test their efficacy in preventing disease against respiratory viral pathogens.
Monitoring hPSC genomic stability in the chromosome 20q region by ddPCR
Authors: Becker Caroline , Aygar Sema , Daheron Laurence 
Published: July 2023

AbstractCopy number increases involving chromosome 20q with gain of the geneBCL2L1are a prevalent form of genomic instability in hPSC. In addition to large aneuploidies, findings in this region often include microamplifications that are too small to detect by G-banded karyotyping. Gene editing procedures warrant especially close monitoring of 20q genomic stability because they involve p53-activating stressors that select for the survival ofBCL2L1-aneuploid cells. Here we describe an optimized strategy for detectingBCL2L1copy number increases in hPSC cultures using duplexed droplet digital PCR (ddPCR) with genomic DNA or cell lysate as the starting material. The procedure consists of droplet generation, thermocycling, droplet reading and data analysis. The expected result is a copy number estimate derived by comparing the number of droplets positive forBCL2L1to the number positive for a reference template,PVRL2. This procedure generates same-day screening results for 1 to 96 samples, providing a convenient option for screening hPSC cultures that is easily integrated into a gene editing workflow.
Color effects on AI influencers’ product recommendations
Authors: Chan Ka Wing , Septianto Felix , Kwon Junbum , Kamal Revathi Sridhar 
Published: July 2023

Purpose
This paper aims to theorize and investigate the use of effective color features in artificial intelligence (AI) influencers, an emerging marketing trend in the social media context.

Design/methodology/approach
By analyzing 6,132 pictures posted by ten AI influencers on Instagram, this paper examines the effect of warm colors in AI influencers’ social media posts on consumer responses, and how other color features may moderate the effect of warm color. In addition, two experimental studies reveal the underlying process driving the effect of warm color.

Findings
Warmer color generated more favorable consumer responses, with brightness significantly moderating the relationship between warm color and favorable consumer responses. Moreover, the results of the experiments establish that perceived warmth and emotional trust mediate the causal effect of warm colors on consumer responses.

Research limitations/implications
There is still little understanding about consumer perceptions of AI influencers and their acceptance of AI influencers’ product recommendations. As such, this research offers theoretical understanding of the color features influencing the effectiveness of recommendations by AI influencers.

Practical implications
Brands have started deploying AI influencers as their brand ambassadors to make product recommendations, representing a new wave of advertising on social media. The findings will thus benefit marketers in developing effective product recommendations using AI influencers.

Originality/value
The present research provides a novel understanding of how visual features, such as color can influence the effectiveness of AI influencers.
The factors affecting learning abilities of university students during COVID pandemic situation
Authors: Saeed Nadia , Abu-Shawiesh Moustafa Omar Ahmed 
Published: July 2023

PurposeThe purpose of the study would typically involve investigating how the ongoing COVID-19 pandemic has impacted the learning abilities of university students. The study could encompass various factors that may influence students' ability to learn, such as their academic performance, motivation, engagement, mental health, access to resources and learning environment.Design/methodology/approach1. A cross-sectional design, collecting data at a specific point in time to capture the impact of the COVID-19 pandemic on students' learning abilities. 2. A structured questionnaire will be developed based on relevant literature and research objectives. 3. The questionnaire could be administered to the targeted sample of university students through online surveys, email or other appropriate methods. 4. Descriptive statistics could be used to summarize the demographic characteristics and other relevant variables of the sample. Factor analysis could be performed to identify underlying factors. The Mann–Whitney test, a non-parametric test, could be used to compare the differences between groups.FindingsThe results of the data analysis would be interpreted and discussed in the context of the research objectives and relevant literature. The findings could provide insights into the factors that significantly affect learning abilities during the COVID-19 pandemic and highlight any differences among groups. Limitations of the study, such as sample size or potential biases, would also be discussed.Originality/valueThe study would provide a comprehensive overview of the impact of the COVID-19 pandemic on university students' learning abilities, highlight the existing literature in the field and establish the need for further research to investigate the factors influencing students' learning abilities during the pandemic. The study can provide a solid framework for similar studies.
Multi-dimensional adjustment of Eurasian self-initiated expatriates in Korea
Authors: Atay Erhan , Bayraktaroglu Serkan , Chew Yin Teng Elaine 
Published: July 2023

PurposeThis qualitative study has two aims. The first is to explore the cognitive, affective, and behavioural dimensions of Eurasian self-initiated expatriates’ (SIEs) work and non-work adjustments in Korea. The second is to understand how the Confucian-oriented Korean culture influences Eurasian SIEs' work and non-work domains, in particular their organisational practices and relations with locals.Design/methodology/approachThis study was conducted through a qualitative analysis of interviews conducted with 27 Eurasian SIEs working in Korea. The interviews were conducted face-to-face with open-ended questions.FindingsEurasian SIEs in Korea express different cognitive, affective, and behavioural life and work adjustment processes that affect their future careers. A high level of language proficiency and knowledge of cultural and social expectations does not guarantee work and life adjustment success. Due to the heavy presence of Korean culture in work and living environments, SIEs face challenges in joining social and work networks and balancing work and life domains, which slows down adjustment. Results indicate that SIEs adjusted well regarding cognitive and behavioural dimensions in work and non-work domains. However, affective adjustment is difficult to achieve, even for SIEs who have lived in the country for many years, and many have the intention to leave if there were other options.Originality/valueThis study contributes to the literature by focussing on the multidimensionality of SIEs' work and life adjustments, with cognitive, affective, and behavioural components. SIEs have been in a complicated process of adaptation and integration for a long time. This study attempts to contribute to SIE literature by analysing the elements of Confucianism-oriented Korean culture and organisational practices prevalent in SIEs' multidimensional adjustment and career challenges.
Framing the Covid‐19 pandemic: A comparative analysis of Swedish and Danish crisis communication
Authors: Sørensen Maja , Evensen Darrick 
Published: July 2023

AbstractWe explore how Swedish and Danish leaders used framing in crisis communication to mobilize support for their Covid‐19 mitigation policies. This research note is grounded in social constructionism and framing theory, analysing how framing in crisis communication is used as a political tool to justify a chosen pandemic strategy. We employ content analysis to compare Swedish and Danish press conferences during the early stages of the Covid‐19 pandemic. Denmark and Sweden are politically and culturally similar countries; however, in March 2020, they chose radically different strategies to respond to the escalating Covid‐19 pandemic. Denmark was one of the first countries in Europe to initiate a lockdown, whereas Sweden kept much of society open. Our findings indicate that Swedish and Danish leaders strategically used framing in their communication to convey understanding of the pandemic that supported their respective agendas. Furthermore, the study contributes insight on how framing is used to justify or question the basis of decision‐making in crises. We argue that through constructing a sense of urgency and emphasizing the uncertain nature of the crisis, scientific evidence as the appropriate basis of decision‐making is challenged, prompting a discussion about the political nature and responsibilities in crisis management.
The role of bacterial colonisation in severity, symptoms and aetiology of hand eczema: The importance of Staphylococcus aureus and presence of commensal skin flora
Authors: Chapsa Maria , Rönsch Henriette , Löwe Tobias , Gunzer Florian , Beissert Stefan , Bauer Andrea 
Published: July 2023

AbstractBackgroundThe role and causality of the microbial ecosystem on the skin in relation to the development of hand eczema (HE) is still unknown.ObjectivesTo investigate the prevalence of different bacterial colonisations in HE patients and their association with the severity, symptoms and aetiology of the disease.MethodsIn a retrospective cohort study of 167 HE patients, bacterial swabs from lesional skin were collected for culturing. Patients were categorised according to bacterial colonisation, HE severity, HE symptoms and HE aetiology.ResultsThe majority of the patients were tested positive for Staphylococcus aureus (S. aureus) (n = 131, 78.4%) and/or commensal skin flora (CSF; n = 130, 77.8%), while other bacteria species were found only sporadically. Severe HE was significantly more prevalent in skin with S. aureus (odds ratio [OR]: 5.13, 95% confidence interval [CI]: 2.21–11.94) and less common in skin with CSF (OR: 0.20, 95% CI: 0.05–0.88). S. aureus colonisation was also associated with atopic HE aetiology (p < 0.001) and acute HE symptoms such as blisters, erosions and crusts (p = 0.003).ConclusionsThe main colonisation of HE patients is with S. aureus and is associated with disease severity, acute HE symptoms and atopic HE aetiology. CSF is associated with mild HE, which could result in new therapeutic approaches.
Ethical consumerism, human rights, and Global Health Impact
Authors: Berkey Brian 
Published: July 2023

AbstractIn this paper, I raise some doubts about Nicole Hassoun's account of the obligations of states, pharmaceutical firms, and consumers with regard to global health, presented in Global Health Impact. I argue that it is not necessarily the case, as Hassoun claims, that if states are just, and therefore satisfy all of their obligations, then consumers will not have strong moral reasons, and perhaps obligations, to make consumption choices that are informed by principles and requirements of justice. This is because there may be justice‐based limits on what states can permissibly and feasibly do both to promote access to existing drugs for all of those who need them, and to promote research and development for new drugs that could treat diseases that primarily affect the global poor. One important upshot of my argument is that there can be reasons for organizations like the Global Health Impact Organization to exist, and to do the kind of work that Hassoun argues is potentially valuable in our deeply unjust world, even in much less unjust worlds in which states and firms largely, or even entirely, comply with their obligations.
Environmental footprinting of hospitals: Organizational life cycle assessment of a Canadian hospital
Authors: Cimprich Alexander , Young Steven B. 
Published: July 2023

AbstractHealthcare is a critical and complex service sector with direct and indirect greenhouse gas (GHG) emissions amounting to 5%–10% of the national total in developed economies like Canada and the United States. Along with a growing, albeit sporadic, set of life cycle assessment (LCA) (and “carbon footprinting”) studies of specific medical products and procedures, there is growing interest in “environmental footprinting” of hospitals. In this article, we advance this rapidly evolving area through a comprehensive organizational LCA of a 40‐bed hospital in British Columbia, Canada, in its 2019 fiscal year. Our results indicate that the total environmental footprint of the hospital includes, among other things, global warming potential of 3500–5000 t CO2 eq. (with 95% confidence). “Hotspots” in this footprint are attributable to energy and water use (and wastewater released), releases of anesthetic gases (which are potent GHGs), and the upstream production of the thousands of materials, chemicals, pharmaceuticals, and other products used in the hospital. The generalizability and comparability of these results are limited by inconsistencies across the few environmental footprinting studies of hospitals conducted to date. Nonetheless, our novel methodological approach, in which we compiled new LCA data for 200 goods and services used in healthcare—strategically selected to statistically represent the 2927 unique products in the hospital's “supply‐chains”—has broad applicability in healthcare and beyond.
The effect of informing the patient about the procedure with video imaging before office hysteroscopy on pain
Authors: Çallıoğlu Nihal , Kanza Gül Derya , Özer Aslan İlke , Fendal Tunca Aysun , Başlı Kasım Kardelen , Akay Burcu , Uysal Elif , Ekin Murat 
Published: July 2023

AbstractObjectiveTo evaluate the effect of informing patients undergoing diagnostic office hysteroscopy via a video 24 h before the procedure and determine the changes in pain scores, channel transit time, the degree of difficulty of the procedure, and physiological parameters.DesignSingle‐blind randomized controlled trial.SettingThe study was conducted between September 1, 2021 and April 1, 2022 at the University of Health Sciences Bakirkoy Dr. Sadi Konuk Training and Research Hospital.ParticipantsA total of 134 patients aged 18–65 years who needed diagnostic office hysteroscopy.InterventionsParticipants were randomized into two groups, the standard information group (Group 1: controls), and the video information + standard information group (Group 2). After office hysteroscopy, a visual analog scale (VAS) and Likert scale were used to assess pain and the degree of difficulty of the procedure, respectively. Physiological parameters were evaluated before and after the procedure.Main Outcome MeasureTo determine the effect of video‐based multimedia information administered 24 h before office hysteroscopy on post‐procedure pain.ResultsThe mean VAS score of the group that watched the training video (3.02 ± 1.88) was significantly lower than the control group (4.72 ± 2.54) who did not watch the training video (p < 0.001). The mean cervical channel transit time in seconds (sec) during the procedure was found to be significantly higher in the control group (21.57 ± 15.10 s) than in the video‐watching group (p = 0.011). There was no significant difference between the groups in terms of physiological parameters and the degree of ease of the procedure.ConclusionOur study has shown that informing patients in a pre‐procedure video is an effective approach that shortens the duration of the channel transit time and reduces pain.
Analyst coverage, executive compensation and corporate risk‐taking: Evidence from property–casualty insurance firms
Authors: Chen Tao , Kamiya Shinichi , Lou Pingyi , Milidonis Andreas 
Published: July 2023

AbstractUsing an exogenous drop in analyst coverage introduced by broker closures and mergers, we test for the causal impact of analyst coverage on corporate risk‐taking, in an opaque industry. We document an increase in risk using several book‐based and market‐based risk measures, including tail and default risk measures. Results are driven by firms with stronger managerial risk‐taking compensation incentives. The increase in risk is stronger in more opaque firms, and firms with weaker policyholder monitoring. Firm risk increases through at least one risk‐taking action, such as investing firm assets in higher‐risk bonds. Our study highlights the importance of stock analysts in affecting corporate risk‐taking, especially in the presence of stronger managerial, compensation risk‐taking incentives.
Interest rate, price level, and the inflation rate: Evidence from the UK during the gold standard regimes
Authors: Choudhry Taufiq 
Published: July 2023

AbstractThis paper empirically investigates the Gibson Paradox and the Fisher Effect for the UK during different metallic and non‐metallic regimes. The paper applies long‐span monthly data on the long‐term interest rate and the price index from 1790 to 1931. The ARDL cointegration is employed to study the long‐term relationship. Significant evidence is provided for the paradox during the uninterrupted gold standard era of the UK (1821–1914). We also find evidence of the paradox during the short‐term gold exchange standard era (1925–1931). Further results also confirm the Fisher Effect during the 1821–1914 period, providing some backing to its ability to explain the paradox. This is further asserted by the short‐run mutual influence between the rate of interest and the inflation rate.