bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Comparison of Accuracy between Traditional Logistic Regression and Gradient Boosting Classifier Model of Artificial Intelligence in Predicting Diabetes Kidney Disease in Chinese – A 4-year Longitudinal Study
Authors: Wu Chung-Ze , Lin Chung-Yu , Chen Fang-Yu , Kuo Chun-Heng , Chen Jin-Shuen , Pitrone Pietro , Huang Li-Ying 
Published: April 2023

Abstract
Background: Type 2 diabetes (T2D) has been increasing recently in Taiwan which causes 43% of the total population of dialysis. In the present study, our goal was to compare the accuracy of logistic regression (LR) and gradient boosting classification (GBC) of artificial intelligence in predicting diabetes kidney disease (DKD) in a Chinese cohort.
Methods: Totally, there were 365 men and 320 women with T2D enrolled and followed for four years. They were further divided into quintiles according to the estimated glomerular filtration rate (eGFR). Both LR and GBC were used to estimate the future DKD. Simple correlation was applied to evaluate the correlation between factors and eGFR at the end of follow-up (eGFR-FU). Sixty percent participants, as training group, were randomly sampled. The others were the validation group. The equations obtained from the training group of both methods are applied to calculate the receiver operation curve (ROC) of the validation group.
Results: At the end of the follow-up, the eGFR-FU significantly different in both genders. The baseline eGFR is negatively related to age, duration of T2D, low density lipoprotein, ALT, systolic blood pressure, but positively related to fasting plasma glucose (FPG) and creatinine in men. In women, the relationship of FPG disappears. The ROC for LR is 0.88 and for GBC is 0.97 for men, and 0.82 and 0.94 for women, respectively. Both findings reach statistically significance.
Conclusion: In conclusion, GBC could provide a better prediction compared to traditional LR in patients with T2D followed up for 4 years.
Using orthogonal Bernoulli polynomials to solve the linear Stratonovich Volterra integral problem system
Authors: Beyranvand Zahra 
Published: April 2023

Abstract
Using orthogonal Bernoulli polynomials, this article describes a method for solving systems of linear Stratonovich Volterra integral equations (OBPs). With the use of operational basis functions (OBFs), their operational integration matrix (OIM), and their stochastic operational integral matrix (SOM), we are able to reduce the original system to a set of linear mathematical models with unknown coefficients. The estimated error associated with the suggested approach is presented. The paper concludes with two related numerical examples to illustrate the methodology’s applicability and its efficiency relative to standard numerical solutions.
Hot spots and trends in inadvertent perioperative hypothermia: a bibliometric and visualized study
Authors: yanyan yang , Luo Lu , Shang Xue , Wu Lei , Sun Zhirong 
Published: April 2023

Abstract
Purpose: Inadvertent perioperative hypothermia (IPH) is a common complication of anesthesia and surgical exposure. Although considerably increased attention has been paid to the role of IPH over the past decades, a systematical bibliometric analysis on this topic has not yet been performed. This study aimed to investigate current research hotspot and predict future trends in IPH research using bibliometric analysis.
Methods: The relevant literatures published from 2000 to 2022 were identified and selected from the Science Citation Index Expanded of Web of Science Core Collection (WoSCC). The VOSviewer and CiteSpace software were used to perform collaboration network analysis, co-citation analysis, co-occurrence analysis, and citation burst detection.
Results: 1685 publications (1450 articles and 235 reviews) from WoSCC were used for analysis and visualization. The United States has made the largest contribution in this field, with most publications (535, 31.8%), and closely collaborations with China and Canada. The most productive institution and scholar in this field were University of Sao Paulo (30, 1.8%) and Professor Braeuer (19, 1.13%), respectively. Anesthesia and Analgesia was the most productive journal. The top ten keywords based on the co-occurrence analysis are “hypothermia”, “cardiopulmonary bypass”, “body temperature, “anesthesia”, “surgery”, “cardiac surgery”, “damage control surgery”, “perioperative hypothermia”, “trauma”, “bleeding”. The emerging research hotspot might be “active warming “, “prewarming”, and “forced-air warming”.
Conclusion: This study analyzed the IPH using bibliometric and visual analysis. These results provide an instructive perspective on the current research and future directions and give a potential foundation for further research and clinical applications.
Endoscopic endonasal dacryocystorhinostomy: is assuming topical anti-glaucoma medications a contraindication?
Authors: Pace Gian Marco , Giombi Francesco , Muci Giovanna , Giunta Gianmarco , Pirola Francesca , Russo Elena , Ferreli Fabio , Vinciguerra Paolo , Mercante Giuseppe , Maria Alessandra Di , Spriano Giuseppe , Malvezzi Luca 
Published: April 2023

Abstract
Purpose Topical anti-glaucoma medications have been investigated on producing fibrotic changes on the conjunctival surface, undermining the functioning of the upper lacrimal drainage system. The aim of the study was to assess whether these effects may impair the effectiveness of dacryocystorhinostomy (DCR) in patients affected by both glaucoma and nasolacrimal duct obstructions (NLDO).Methods Single-center observational retrospective study on endoscopic endonasal-DCR (EE-DCR) via posterior approach. Consecutive patients were enrolled in 2020–2023 and evaluated with proper questionnaires; resolution of epiphora and dacryocystitis were analyzed after 1 (T1) and 6-months (T2) from surgery. Surgical success was defined as anatomical (patency at irrigation, no recurring dacryocystitis) or complete (zeroing of Munk score)Results 17 patients (29 operated sides) were enrolled. Preoperatively, 92.1% (n = 27/29) presented severe (Munk 3–4) epiphora and 69.0% (n = 20/29) recurrent dacryocystitis. At T1, 51.72% (n = 15/29) referred residual epiphora (Munk ≥ 1) and 17.20% (n = 5/29) dacryocystitis. At T2, 34.5% (n = 10/29) still complained epiphora (Munk ≥ 1) and 6.9% (n = 2/29) symptoms of dacryocystitis. Difference of outcomes at aggregate and paired timepoints (except for T1 versus T2) resulted statistically significant (p < 0.05). At T2, 20 (69.0%) complete, 7 (24.2%) anatomical successes and 2 surgical failures (6.8%) were observed.Conclusions EE-DCR in patients suffering from NLDO despite the chronic uptake of anti-glaucoma topical medications guaranteed high rates of clinical relief from epiphora and remarkable decreases in the rates of recurrent dacryocystitis, appearing as a reasonable therapeutical strategy to improve disease-related quality of life.
Network Analysis of Neuropsychiatric Symptoms in Alzheimer’s Disease
Authors: Goodwin Grace J. , Moeller Stacey , Nguyen Amy , Cummings Jeffrey L. , John Samantha E. 
Published: April 2023

Abstract
Background:
Neuropsychiatric symptoms due to Alzheimer’s disease (AD) and mild cognitive impairment (MCI) can decrease quality of life for patients and increase caregiver burden. Better characterization of neuropsychiatric symptoms and methods of analysis are needed to identify effective treatment targets. The current investigation leveraged the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set (UDS) to examine the network structure of neuropsychiatric symptoms among symptomatic older adults with cognitive impairment.
Methods:
The network relationships of behavioral symptoms was estimated from Neuropsychiatric Inventory Questionnaire (NPI-Q) data acquired from 12,494 older adults with MCI and AD during their initial visit. Network analysis provides insight into the relationships among sets of symptoms and allows calculation of the strengths of the relationships. Nodes represented individual NPI-Q symptoms and edges represented the pairwise dependency between symptoms. Node centrality was calculated to determine the relative importance of each symptom in the network.
Results:
The analysis showed patterns of connectivity among the symptoms of the NPI-Q. The network (M=.28) consisted of mostly positive edges. The strongest edges connected nodes within symptom domain. Disinhibition and agitation/aggression were the most central symptoms in the network. Depression/dysphoria was the most frequently endorsed symptom, but it was not central in the network.
Conclusions:
Neuropsychiatric symptoms in MCI and AD are highly comorbid and mutually reinforcing. The presence of disinhibition and agitation/aggression yielded a higher probability of additional neuropsychiatric symptoms. Interventions targeting these symptoms may lead to greater neuropsychiatric symptom improvement overall. Future work will compare neuropsychiatric symptom networks across dementia etiologies, informant relationships, and ethnic/racial groups, and will explore the utility of network analysis as a means of interrogating treatment effects.
The Prognosis and Immunotherapy Prediction of Cuproptosis-Related Genes in Head and Neck Squamous Cell Carcinoma
Authors: Su Xin , Yu Na , Zhou： JiaWei , Guo Jiayan 
Published: April 2023

Abstract
Background To determine the role of cuproptosis-related genes in head and neck squamous cell carcinoma, and establish a new prognosis model and provide a novel therapeutic target.Methods We extracted gene expression, mutation information, and clinical data of HNSC patients through TCGA and GTEx. Then use R, GEEA, SPSS to analyze Cuproptosis-related genes, include differential gene expression, prognostic analysis, survival prediction analysis, correlation pathway analysis, and immune correlation analysis. The clinical samples were used for immunohistochemistry and PCR to verify the analytical results.Results We analyzed 39 normal samples and 469 HNSC to show the co-expression relationship between LncRNA and cuproptosis-related genes. A prediction model was established in predicting the survival rate and the survival period of patients. The expression of LIPT1 gradually increased with clinical grading, which was further verified by immunohistochemistry and qRT-PCR. LIPT1 is an independent prognostic factor of HNSC, and may be related to the occurrence of HNSC. Immunocyte reduction and immune escape existed in LIPT1 over-expression group.Conclusions Our findings demonstrate that cuproptosis-related genes can predict the risk, progression and prognosis of HNSC. LIPT1 is related to the tumor grading of HNSC, and it can be used as an independent prognostic factor and a novel target for HNSC immunotherapy.
Genotypic variations appear in fine root morphological traits of Cryptomeria japonica trees grown in a common garden
Authors: Nakahata Ryo , Azuma Wakana A. , Tanabe Tomoko , Kawai Kiyosada , Hiura Tsutom 
Published: April 2023

Abstract

Aims Fine root morphological traits regulate the belowground resource acquisition strategies of trees. However, genotypic variations isolated from environmental variations within tree species remain unclear. Thus, this study aimed to clarify the effects of genotypic variations on the fine root morphology of three types of Japanese cedar (Cryptomeria japonica), which were derived from different provenances but were grown in a common garden.Methods In the three geographically different provenances of C. japonica stands (Yanase, Yoshino, and Yaku), fine root morphological traits, such as root length and diameter and specific root length (SRL), were measured for each root up to the 4th branching order.Results Yaku cedar exhibited root traits distinct from the other provenances, such as growing longer and thinner roots in 1st root order to enhance root surface area. In addition, the SRL patterns with root orders and higher root tissue density suggested a resource conservation strategy corresponding to the low aboveground production of Yaku cedar. Yanase cedar demonstrated a significantly higher root branching ratio and specific root tips than the other provenances, indicating a strategy for investing resources in absorptive roots. Although Yoshino cedar had traits similar to that of Yanase cedar or intermediate between Yanase and Yaku cedars, high aboveground production may be achieved by nutrient acquisition with root exudates instead of absorptive root growth.Conclusion Genotypic variations appeared in fine root morphological traits of C. japonica trees, even when grown in the same environments, implying distinct resource acquisition strategies characterized by each provenance.
Evaluation of self-regulation by the hunting community: A case study on the voluntary restraint of woodcock hunting in the UK
Authors: McNicol Catherine M. , Ellis Matthew B. , Warrender Heather E. 
Published: April 2023

Abstract

The self-regulation of hunting activity in the United Kingdom is a vital part of improving the sustainability of wild bird harvest. In recent years, there have been calls to voluntarily delay the open season for shooting woodcock to reduce any potential impact on resident breeding birds. This call for voluntary behaviour change offers an opportunity to assess bag data, in the form of wings of shot birds submitted, and understand if hunters are adhering to these self-imposed regulations. Of the woodcock wings submitted 87% adhered to the voluntary delay to the season, suggesting that this initiative has secured broad voluntary compliance. This demonstrates that that with suitable messaging, and a collective effort to conserve wild quarry, that legislative changes may not be necessary to achieve sustainable harvest rates.
Phage tailspike modularity and horizontal gene transfer reveals specificity towards E. coli O-antigen serogroups
Authors: Pas Célia , Latka Agnieszka , Fieseler Lars , Briers Yves 
Published: April 2023

Abstract
Background

The interaction between bacteriophages and their hosts is intricate and highly specific. Receptor-binding proteins (RBPs) of phages such as tail fibers and tailspikes initiate the infection process. These RBPs bind to diverse outer membrane structures, including the O-antigen, which is a serogroup-specific sugar-based component of the outer lipopolysaccharide layer of Gram-negative bacteria. Among the most virulent E. coli strains is the Shiga toxin-producing Escherichia coli (STEC) pathotype dominated by a subset of O-antigen serogroups.

Methods

Extensive phylogenetic and structural analyses were used to identify and validate specificity correlations between phage RBP subtypes and STEC O-antigen serogroups, relying on the principle of horizontal gene transfer as main driver for RBP evolution.

Results

We identified O-antigen specific RBP subtypes for seven out of nine most prevalent STEC serogroups (O26, O45, O103, O104, O111, O145 and O157) and seven additional E. coli serogroups (O2, O8, O16, O18, 4s/O22, O77 and O78). Eight phage genera (Gamaleya-, Justusliebig-, Kaguna-, Kayfuna-, Kutter-, Lederberg-, Nouzilly- and Uetakeviruses) emerged for their high proportion of serogroup-specific RBPs. Additionally, we reveal sequence motifs in the RBP region, potentially serving as recombination hotspots between lytic phages.

Conclusion

The results contribute to a better understanding of mosaicism of phage RBPs, but also demonstrate a method to identify and validate new RBP subtypes for current and future emerging serogroups.
Teaching pre-clinical medical students remotely in Nigeria post Covid-19 pandemic: Can past experiences shape future directions?
Authors: Emma-Okon Beatrice , Akomolafe Rufus , Ayannuga Olugbenga , Tombs Michal 
Published: April 2023

Abstract

Purpose - Online teaching has gained popularity in recent years, but changes have been slower to implement in Lower to Medium Income Countries (LMIC). The aim of this research was to build upon educators’ experiences of remote teaching during Covid-19 to inform the development of a blended learning approach for teaching pre-clinical subjects at Obafemi Awolowo University, Nigeria (OAU).
Methods - The Critical Incident Technique (CIT) was used in this exploratory study. Participants were invited to either complete an online qualitative questionnaire or take part in an online interview, which were hosted on Microsoft platforms. Data were obtained from eighteen educators and were analyzed using thematic analysis.
Results - Five main themes captured educators’ experiences of online teaching including: skill and training, teachers’ motivation and attitudes, internet and connectivity, learners’ behaviors, and socio-economic constraints. They considered remote teaching beneficial and suggested that some form of asynchronized online teaching should continue to support face to face teaching.
Conclusion - Findings provided additional evidence on the way in which educators in LMIC would like to build upon the positive aspects of online teaching and move towards a blended learning model, considering the socio-economic constraints.
O(1 kHz) In-Lab X-ray Particle Velocimetry for Multiphase Flows
Authors: Parker Jason T. , Dreier Till , Nilsson Daniel , Mäkiharju Simo A. 
Published: April 2023

Abstract
We combine X-ray-specific tracer particles, a photon counting detector, and a liquid metal anode X-ray source to achieve O(1 kHz) X-ray imaging speeds in the laboratory, 15x faster than previous comparable studies. To demonstrate the capabilities of these imaging speeds, we conduct three experiments: 2D and 3D X-ray particle tracking velocimetry (XPTV) of Poiseuille pipe flow, 3D XPTV of flow around a Taylor bubble, and 3D scalar mixing with a laminar jet. These experiments demonstrate the performance improvement of combining the aforementioned elements, the applicability to multiphase flows and deforming systems, and the potential to capture scalar and vector quantities simultaneously. Most importantly, these experiments are conducted in the laboratory, showing that in-lab X-ray particle velocimetry techniques are now usable for a wider range of flows of interest.
Complete genome sequence analysis of plant growth-promoting bacterium, Isoptericola sp. AK164 isolated from the rhizosphere of Avicennia marina growing at the Red Sea coast
Authors: Alghamdi Amal Khalaf , Parween Sabiha , Hirt Heribert , Saad Maged M. 
Published: April 2023

Abstract
Isoptericola sp. AK164 is a Gram-positive, aerobic bacterial genus from the family Promicromonosporaceae, isolated from the root rhizosphere of Avicennia marina. AK164 significantly enhanced the growth of the Arabidopsis thaliana plant under normal and saline conditions. These bacteria can produce ACC deaminase and several enzymes playing a role in carbohydrate hydrolyses, such as cellulose, hemicellulose, and chitin degradation, which may contribute to plant growth, salt tolerance, and stress elevation. The genome sequence AK164 has a single circular chromosome of approximately 3.57 Mbp with a GC content of 73.53 %. A whole genome sequence comparison of AK164 with type strains from the same genus, using digital DNA–DNA hybridization and average nucleotide identity calculations, revealed that AK164 might potentially belong to a new species of Isoptericola. Genome data and biochemical analyses indicate that AK164 could be a potential biostimulant for improving agriculture in submerged saline land.
Potential of overpowering Drugs Resistance in MC F-7/Adr cells by regulation of apoptotic pathways using sorafenib incorporating chitosan conjugated folic acid nanoparticles: An Experimental Study
Authors: Hassan Asmaa , Nabil Ahmed , Ali Islam S. , Reyd Zeinab , Ahmed Osama M. , El-Shahawy Ahmed A. G. 
Published: April 2023

Abstract
Introduction:
To overcome drug resistance and induce apoptosis in MCF-7/Adr human breast cancer cells which has a multidrug resistance, this study aims to develop a novel formulation of chitosan-sorafenib-conjugated FA nanoparticles (CsNPs-Sor-FA) for the efficient treatment of breast cancer.
Methods
The prepared formula was analyzed by using the FTIR, XRD, HRTEM, and UV-VIS spectrometers. A drug release experiment was performed in vitro, and the loading capacity and entrapment efficiency were estimated. The MTT assay was used to test for cytotoxicity. The nanoformula (CsNPs-Sor-FA) was tested as an anticancer treatment against MCF-7/adr cells by flow cytometry assay, cell cycle analysis, DNA fragmentation assay, real-time quantitative PCR (qRT-PCR), and western blot.
Results
We found that the CsNPs-Sor-FA formation had an average particle size of about 60 nm, an entrapment efficiency of 79 ± 2.9%, and a loading capacity 13.6 ± 1.2%. Around 90% of sorafenib was released from CsNPs-Sor after 120 hours, whereas CsNPs-Sor-FA nanoparticles exhibited an 88% sustained release pattern. The tested formulation of CsNPs-Sor-FA was not lethal to healthy lung cells. In addition, the morphological changes and DNA fragmentation results indicate that treatment with CsNPs-Sor-FA resulted in higher apoptosis data. Inhibition of cell cycle progression and inhibition of Nrf2 were also higher with CsNPs-Sor-FA treatment. Upregulation of apoptosis markers p53, caspase 9, caspase 8 and caspase 3, cytochrome c and TNFR was also observed; in contrast, expression of the anti-apoptotic marker Bcl-2 was reduced in the CsNPs-Sor-FA treated group compared to their individual treatments. Therefore, the nanoformula (CsNPs-Sor-FA) can be very useful for treating breast cancer.
Conclusion
Therefore, the present study has developed a nanoformula that shows promising antitumor activity against breast cancer cells and can improve survival rate of breast cancer patients.
Teamwork in community health committees: a case study in two urban informal settlements
Authors: Karuga Robinson , Khan Sitara , Kok Maryse , Moraa Malkia , Mbindyo Patrick , Broerse Jacqueline , Dieleman Marjolein 
Published: April 2023

Abstract
Background Community health committees (CHCs) are mechanisms for community participation in decision-making and overseeing health services in several low-and middle-income countries (LMICs). There is little research that examines teamwork and internal team relationships between members of these committees in LMICs. We aimed to assess teamwork and factors that affected teamwork of CHCs in an urban slum setting in Nairobi, Kenya.Methods Using a qualitative case-study design, we explored teamwork of two CHCs based in two urban informal settlements in Nairobi. We used semi-structured interviews (n = 16) to explore the factors that influenced teamwork and triangulated responses using three group discussions (n = 14). We assessed the interpersonal and contextual factors that influenced teamwork using a framework for assessing teamwork of teams involved in delivering community health services.Results Committee members perceived the relationships with each other as trusting and respectful. They had regular interaction with each other as friends, neighbors and lay health workers. CHC members looked to the Community Health Assistants (CHAs) as their supervisor and “boss”, despite CHAs being CHC members themselves. The lay-community members in both CHCs expressed different goals for the committee. Some viewed the committee as informal savings group and community-based organization, while others viewed the committee as a structure for supervising Community Health Volunteers (CHVs). Some members doubled up as both CHVs and CHC members. Complaints of favoritism arose from CHC members who were not CHVs whenever CHC members who were CHVs received stipends after being assigned health promotion tasks in the community. Underlying factors such as influence by elites, power imbalances and capacity strengthening had an influence on teamwork in CHCs.Conclusion In the absence of direction and support from the health system, CHCs morph into groups that prioritize the interests of the members. This redirects the teamwork that would have benefited community health services to other common interests of the team. Teamwork can be harnessed by strengthening the capacity of CHC members, CHAs, and health managers in team building and incorporating content on teamwork in the curriculum for training CHCs.