bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dose and Time Dependent Protective Effects of Apocyanin and Curcumin Against Diclofenac-Induced Cardiotoxicity in Male Rats
Authors: Okwakpam Felicia N. , Igwe Felix U. , Omeodu Stephen I. , Monanu Michael O. 
Published: May 2023

This study explored the protective potential of apocyanin and curcumin in diclofenac-induced cardiotoxicity utilizing cardiac enzymes, pro-inflammatory markers, and along with histopathological endpoints. A total of 123 male Wistar rats were used for the study. 43 rats were used for the determination of the median lethal dose (LD50) of apocyanin and curcumin while 80 rats were randomly divided into 8 groups of 10 rats each. Group 1(control) received distilled water while others received orally, per mg/kg body weight of treatments as follows: group 2(1000, apocyanin, group 3(1000, curcumin), group 4(10, diclofenac), group 5(500, apocyanin and 10, diclofenac), group 6(1000, apocyanin and 10, diclofenac), group 7(500, curcumin and 10, diclofenac) and group 8(1000, curcumin and 10, diclofenac). The treatments were administered daily for 14 and 28 days. LD50 up to 5000mg/kg body weight of apocyanin and curcumin did not show any fatality in animals. Administration of diclofenac significantly (p < 0.05) elevated the activities of creatinine kinase-MB, lactate dehydrogenase, levels of troponin-T, and tumor necrosis factor. There was no alteration in the activities of Interleukin- 1β. The histological results also showed cardiac insults such as cardiac muscle having severe fibro collagenous stroma, reduced myocytes density, and thick wall blood vessels. However, pretreatment with 500 and 1000 mg/kg body weight of apocyanin or curcumin attenuated all biochemical alterations and histological lesions induced by diclofenac in a dose-dependent manner. Pretreatments with apocyanin and curcumin inhibitors of NADPH oxidases 2weres effective in ameliorating diclofenac-induced cardiotoxicity suppressing inflammation and restoring normal histological architecture, thus, highlighting the therapeutic potentials of apocyanin and curcumin in the management of diclofenac-mediated cardiotoxicity.
Effect of Soil and Climatic Conditions on Brown Spot Occurrence in Rice Lowland across Four Agro-climatic Zones of Côte d’Ivoire
Authors: Adanvé Jean-Fabrice , Koné Brahima , Sikirou Rachidatou , Dossou-Yovo Elliott , Onaga Geoffrey , Sorho Fatogoma 
Published: May 2023

Aims: To evaluate interaction of soil pH and acidity with weather on Rice Brown spot (BS) occurrence in rice lowlands.
Study Design: Cross sectional study.
Place and Duration of Study: Four distinct rice lowlands belonging to different climatic zones (forest, transitional and savanna) of Côte d’Ivoire during cropping seasons of 2021.
Methodology: BS characterization were done in different farmer fields where soil samples were also collected during dry and rainy seasons. Soil silicon and acidity were determined in those samples and rice grain yield at harvest time were recorded in different sites. Weather data related to sites and seasons were used to find out correlations.
Results: Occurrence of BS was found in forest zones with scores of 4 and 3 compared to 1 and 2 in savanna and transitional zones, respectively, with seasonal variation. Both rice production and the occurrence of BS were explained by soil parameters in conjunction with climatic parameters. Rainfall (R=0.38) and relative humidity (R=0.64) leaded BS occurrence and decrease of yield. Wind speed (R=0.62) and air maximum temperature (R= 0.63) were the determinant factors affecting rice yields. Si was found to be a component of sustainable soil management that interferes with soil pH in all climatic zones. Combined with Temperature, both soil parameters predicted BS occurrence over 50%.
Conclusion: Temperature decrease BS pathogens occurrence whereas high humidity increases its spread. Those parameters combined with silicon which interferes with pH could leads sustainable solutions in BS control. Furthermore, having a deep understanding with rice varietal considerations can significantly improve strategies related to rice cultivation and protection.
Long-term Safety and Efficacy of Closure of Mesenteric Defects in Laparoscopic Gastric Bypass Surgery
Authors: Stenberg Erik , Ottosson Johan , Magnuson Anders , Szabo Eva , Wallén Stefan , Näslund Erik , Thorell Anders , Näslund Ingmar 
Published: May 2023

ImportanceShort-term and midterm data suggest that mesenteric defects closure during laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery reduces the risk of internal herniation with small bowel obstruction (SBO) but may increase risk of kinking of the jejunojejunostomy in the early postoperative period. However, to our knowledge, there are no clinical trials reporting long-term results from this intervention in terms of risk for SBO or opioid use.ObjectiveTo evaluate long-term safety and efficacy outcomes of closure of mesenteric defects during LRYGB.Design, Setting, and ParticipantsThis randomized clinical trial with a 2-arm, parallel, open-label design included patients with severe obesity scheduled for LRYGB bariatric surgery at 12 centers in Sweden from May 1, 2010, through November 14, 2011, with 10 years of follow-up after the intervention.InterventionsDuring the operation, patients were randomly assigned 1:1 to closure of mesenteric defects beneath the jejunojejunostomy and at the Petersen space using nonabsorbable running sutures during LRYGB or to nonclosure.Main Outcome and MeasuresThe primary outcome was reoperation for SBO. New incident, chronic opioid use was a secondary end point as a measure of harm.ResultsA total of 2507 patients (mean [SD] age, 41.7 [10.7] years; 1863 female [74.3%]) were randomly assigned to closure of mesenteric defects (n = 1259) or nonclosure (n = 1248). After censoring for death and emigration, 1193 patients in the closure group (94.8%) and 1198 in the nonclosure group (96.0%) were followed up until the study closed. Over a median follow-up of 10 years (IQR, 10.0-10.0 years), a reoperation for SBO from day 31 to 10 years after surgery was performed in 185 patients with nonclosure (10-year cumulative incidence, 14.9%; 95% CI, 13.0%-16.9%) and in 98 patients with closure (10-year cumulative incidence, 7.8%; 95% CI, 6.4%-9.4%) (subhazard ratio [SHR], 0.42; 95% CI, 0.32-0.55). New incident chronic opioid use was seen among 175 of 863 opioid-naive patients with nonclosure (10-year cumulative incidence, 20.4%; 95% CI, 17.7%-23.0%) and 166 of 895 opioid-naive patients with closure (10-year cumulative incidence, 18.7%; 95% CI, 16.2%-21.3%) (SHR, 0.90; 95% CI, 0.73-1.11).Conclusions and RelevanceThis randomized clinical trial found long-term reduced risk of SBO after mesenteric defects closure in LRYGB. The findings suggest that routine use of this procedure during LRYGB should be considered.Trial RegistrationClinicalTrials.gov Identifier: NCT01137201
Effects of Specialist Palliative Care for Patients Undergoing Major Abdominal Surgery for Cancer
Authors: Shinall Myrick C. , Martin Sara F. , Karlekar Mohana , Hoskins Aimee , Morgan Ellis , Kiehl Amy , Bryant Patsy , Orun Onur M. , Raman Rameela , Tillman Benjamin F. , Hawkins Alexander T. , Brown Alaina J. , Bailey Christina E. , Idrees Kamran , Chang Sam S. , Smith Joseph A. , Tan Marcus C. B. , Magge Deepa , Penson David , Ely E. Wesley 
Published: May 2023

ImportanceSpecialist palliative care benefits patients undergoing medical treatment of cancer; however, data are lacking on whether patients undergoing surgery for cancer similarly benefit from specialist palliative care.ObjectiveTo determine the effect of a specialist palliative care intervention on patients undergoing surgery for cure or durable control of cancer.Design, Setting, and ParticipantsThis was a single-center randomized clinical trial conducted from March 1, 2018, to October 28, 2021. Patients scheduled for specified intra-abdominal cancer operations were recruited from an academic urban referral center in the Southeastern US.InterventionPreoperative consultation with palliative care specialists and postoperative inpatient and outpatient palliative care follow-up for 90 days.Main Outcomes and MeasuresThe prespecified primary end point was physical and functional quality of life (QoL) at postoperative day (POD) 90, measured by the Functional Assessment of Cancer Therapy–General (FACT-G) Trial Outcome Index (TOI), which is scored on a range of 0 to 56 with higher scores representing higher physical and functional QoL. Prespecified secondary end points included overall QoL at POD 90 measured by FACT-G, days alive at home until POD 90, and 1-year overall survival. Multivariable proportional odds logistic regression and Cox proportional hazards regression models were used to test the hypothesis that the intervention improved each of these end points relative to usual care in an intention-to-treat analysis.ResultsA total of 235 eligible patients (median [IQR] age, 65.0 [56.8-71.1] years; 141 male [60.0%]) were randomly assigned to the intervention or usual care group in a 1:1 ratio. Specialist palliative care was received by 114 patients (97%) in the intervention group and 1 patient (1%) in the usual care group. Adjusted median scores on the FACT-G TOI measure of physical and functional QoL did not differ between groups (intervention score, 46.77; 95% CI, 44.18-49.04; usual care score, 46.23; 95% CI, 43.08-48.14; P = .46). Intervention vs usual care group odds ratio (OR) was 1.17 (95% CI, 0.77-1.80). Palliative care did not improve overall QoL measured by the FACT-G score (intervention vs usual care OR, 1.09; 95% CI, 0.75-1.58), days alive at home (OR, 0.87; 95% CI, 0.69-1.11), or 1-year overall survival (hazard ratio, 0.97; 95% CI, 0.50-1.88).Conclusions and RelevanceThis randomized clinical trial showed no evidence that early specialist palliative care improves the QoL of patients undergoing nonpalliative cancer operations.Trial RegistrationClinicalTrials.gov Identifier: NCT03436290
Broadband Response and a Transformation between Dual‐ and Single‐Wavelength Detection in Coupled Doped‐Well Quantum Cascade Detector
Authors: Chen Jie , Chen Fengwei , Wu Yuyang , Wang Xuemin , Jiang Tao , Li Yang , Li Bicheng , Zhang Jincang , Wu Weidong , Che Renchao 
Published: May 2023

AbstractAs a third‐generation infrared detector, the quantum cascade detector (QCD) exhibits an accurately adjustable wavelength, low noise, and ultrafast response characteristics. By introducing an additional doping layer, QCD also shows excellent application prospects in the broadband response. Herein, a coupled doped‐well QCD with an array structure located at very long‐wave infrared (VLWIR, ≈15 µm) is prepared. Based on the energy levels interaction and carrier distribution, the regulatory mechanism of the applied bias on the response characteristics is explored. At zero bias, the detector exhibits dual‐wavelength detection owing to the splitting of the energy levels, then transforms into single‐wavelength detection with the bias increasing. Simultaneously, the QCD device exhibits a broadband response (≈13–16 µm) from 15 to 300 K and an excellent detectivity of 1.52 × 1012 cm Hz1/2 W−1 at 15 K. A high R0A (>106 Ω cm2) and robust detectivity (>109 cm Hz1/2 W−1) are obtained at room temperature. The results of the response characteristics presented in this work provide a strategy for the flexible application of QCD in infrared detection.
Persistent chylothorax associated with lymphatic malformation type 6 due to biallelic pathogenic variants in PIEZO1
Authors: Kovesi Thomas , Rojas Samantha K. , Boycott Kym M. 
Published: May 2023

AbstractPIEZO1 is required for lymphatic valve formation, and several lymphatic abnormalities have been reported to be associated with autosomal recessive PIEZO1 pathogenic variants including neonatal hydrops, lymphedema involving various body regions, and chylothorax. Persistent or recurrent chylothorax has been infrequently described in association with pathogenic variants in the PIEZO1 gene. We present a 4‐year‐old female with bilateral pleural effusions detected prenatally, who was diagnosed with bilateral chylothoraces post‐partum. She subsequently had recurrent pleural effusions involving both pleural cavities, which tended to improve with restriction of her fat intake, and, one occasion, subcutaneous octreotide. She also had bilateral calf, and intermittent cheek swelling. Genetic testing revealed two deleterious variants in PIEZO1: c.2330‐2_2330‐1del and c.3860G > A (p.Trp1287*), both of which were classified as likely pathogenic. This supported a diagnosis of Lymphatic Malformation Type 6 (OMIM 616843), also known as Hereditary Lymphedema Type III. Hereditary Lymphedema type III can be associated with persistent chylothorax that can vary in size over time.
Chemical Solutions to the Current Polycrisis
Authors: Gomollón‐Bel Fernando , García‐Martínez Javier 
Published: May 2023

AbstractIn the past 15 years, we've experienced an unprecedented series of crises, including financial (2008), health (2020), and most recently the supply chain disruptions and the energy emergency in Europe, caused by the war in Ukraine (2022). On top of that, climate change still poses a serious threat to our lives and our planet. These interconnected challenges create tremendous societal problems and compromise the viability of the chemical industry in an environment of price volatility and high inflation. Thus, the International Union of Pure and Applied Chemistry (IUPAC) has launched a series of actions to tackle this and raise awareness of the role of chemistry in solving our major threats. Since 2019, IUPAC has identified the “Top Ten Emerging Technologies in Chemistry” to connect chemical researchers with industry, bridging the gap between science and innovation, maintaining the current competitiveness of the chemical industry, as well as tackling our most pressing global challenges.
Optimization of CeO2 and MgO nano‐particle‐added mango seed biodiesel blends using hybrid deep belief network‐coupled sandpiper optimizer
Authors: Reddy S. Rami , Sarangi Saroj Kumar 
Published: May 2023

AbstractThe ultimate goal of this study is to find a better method for minimizing hazardous emissions from a diesel engine. For this reason, emission parameters such as smoke, nitrogen oxides (NOX), unburned hydrocarbons, and carbon monoxide from a single‐cylinder diesel engine were analyzed using various biodiesel blends. The biodiesel was extracted from mango seed oil through trans‐esterification and combined with pure diesel at a 2:8 ratio. The prepared biodiesel (MSME20) was further mixed with 50, 100, and 150 ppm of either cerium oxide (CeO2) or magnesium oxide (MgO) nano‐particles through ultra‐sonication to prepare various fuel blends. The results reported that the addition of nano‐particles significantly lowered CO, HC, and smoke opacity by 25%, 25%, and 28% when compared with diesel. Also, there was a nearly 16% brake thermal efficiency gain from 50 ppm nano‐particle‐added MSME20 than pure MSME20. But for NOX emission, MSME20 fuel produced 106 ppm more NOX than diesel. Later, it was reduced up to 24 ppm while adding 50 ppm nano‐particles into MSME20 fuel. Further, a hybrid deep belief network‐coupled sandpiper optimizer was developed to optimize fuel blends. The proposed algorithm showed 37.5 ppm nano‐particle added 17.5% MSME as an optimal mix for the tested engine while running with 50% load.
Assessment of the nesting population demography of loggerhead turtles (Caretta caretta) in La Roche Percée: First long‐term monitoring in New Caledonia
Authors: Barbier Maxime , Lafage Dominique , Bourgogne Hugo , Read Tyffen , Attard Marine , Fournière Kevin , Chapuis Kennie , Peyrot Yolanda , Deffois Michèle , Guillaumet Bernard , Sibeaux Adelaide 
Published: May 2023

Abstract

Population monitoring is essential to assess, manage, and protect threatened species. Although the South Pacific loggerhead turtle (Caretta caretta) subpopulation is classified as Critically Endangered by the International Union for Conservation of Nature (IUCN), monitoring data are scarce.
This study reports the results of the first long‐term monitoring of the nesting population of loggerhead turtle held by Bwärä Tortues Marines on La Roche Percée beach, New Caledonia.
From 2006 to 2020, capture–mark–recapture was used to identify nesting individuals. Time and nesting success were recorded on site.
A total of 452 different females were observed and tagged over 14 years. The number of different nesting individuals observed each year showed a significant increase over the time frame of the study. A remigration interval of 3.34 years was observed, and the overall nesting success was 59.02%. This study also reports the internesting intervals and monthly and hourly variabilities in visits to the nesting site.
The conservation actions led by Bwärä Tortues Marines appear to be correlated with a higher nesting success. This study provides encouraging results and highlights the need to pursue the monitoring and conservation actions implemented by Bwärä Tortues Marines. Further management recommendations are also provided.
The application of hybrid feature based on local mean decomposition for motor imagery electroencephalogram signal classification
Authors: Li LinLin , Chen WanZhong , Li MingYang 
Published: May 2023

AbstractThis paper proposed a hybrid feature extraction algorithm based on local mean decomposition (LMD), which has better solved the existing problems of low classification performance and adaptability limitation. LMD is employed to decompose the electroencephalogram (EEG) signal into multiple components, and then, the hybrid features based on instantaneous energy, fuzzy entropy, and mathematical morphological features are extracted on specific components, and the optimal feature combination is selected by analysis of variance (ANOVA). Finally, the classification result is output by the linear discriminant analysis (LDA) classifier. The results show that the maximum accuracy of the subjects in Data Set III of BCI‐II by the method in this paper is 92.14%, and the maximum mutual information value is 0.8. The number of novel features used in this paper is small, and the complexity of the algorithm is reduced. It can adaptively select effective features according to individual differences and has good robustness.
Cladosporin, A Highly Potent Antimalaria Drug?
Authors: Hou Anwei , Li Bei , Deng Zixin , Xu Min , Dickschat Jeroen S. 
Published: May 2023

AbstractCladosporin, a unique natural product from the fungus Cladosporium cladosporioides, exhibits nanomolar inhibitory activity against Plasmodium falciparum by targeting its cytosolic lysyl‐tRNA synthetase (PfKRS) to inhibit protein biosynthesis. Due to its exquisite selectivity towards pathogenic parasites, cladosporin has become a very promising lead compound for developing antiparasitic drugs to treat drug‐resistant malaria and cryptosporidiosis infections. Here we review the recent research progress of cladosporin covering aspects of the chemical synthesis, biosynthesis, bioactivity, cellular target and structure–activity relationship.
A case of unsuccessful obliteration of percutaneous transhepatic gastric varices using the IMPEDE embolization plug
Authors: Masuda Sakue , Tsukiyama Toshitaka , Makazu Makomo , Jinushi Ryuhei , Koizumi Kazuya , Nishino Takashi , Shionoya Kento , Kimura Karen , Sumida Chihiro , Kubota Jun , Ichita Chikamasa , Sasaki Akiko , Kobayashi Masahiro , Kako Makoto , Uojima Haruki 
Published: May 2023

Key Clinical MessageEmbolization with IMPEDE embolization plug cannot be confirmed on site. Therefore, we propose that the diameter of the device selected be up to 50% larger than the vein diameter to prevent embolization failure and recanalization.AbstractBalloon‐occluded retrograde transvenous obliteration and percutaneous transhepatic obliteration (PTO) are performed for treating sporadic gastric varices. IMPEDE embolization plug has been recently developed for these procedures; however, no studies have reported its use. This is the first report on its use in PTO of gastric varices.
PROTOCOL: Health and social care interventions in the 80 years old and over population: An evidence and gap map
Authors: Abbott Rebecca , Thompson Coon Jo , Bethel Alison , Rogers Morwenna , Whear Rebecca , Orr Noreen , Garside Ruth , Goodwin Victoria , Mahmoud Aseel , Lourida Ilianna , Cheeseman Debbie 
Published: May 2023

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows: identify available systematic reviews and randomised controlled trials on interventions targeting health or social needs of the people aged over 80; identify qualitative studies relating to the experiences of people aged over 80 of interventions that target their health or social needs; identify areas where systematic reviews are needed; identify gaps in evidence where further primary research is needed; assess equity considerations (using the PROGRESS plus criteria) in available systematic reviews, randomised trials and qualitative studies of identified interventions; assess gaps and evidence related to health equity.
A Combined Theoretical and Experimental Approach to Deduce the Role of Dielectric Layer on Interface Trap Density in Single Crystal Organic Field‐Effect Transistors
Authors: Bhattacharya Arka , Praveen Periyasamy Angamuthu , R. Yashwanth Yeti Rajan , Thangavel Kanagasekaran 
Published: May 2023

AbstractA detailed understanding of charge transport at the interface is necessary to explore the potential of organic field‐effect transistors. This can be realized by adequately analyzing the trap states at the interface. In the present work, rubrene‐based organic field‐effect transistors have been fabricated with three different interfaces. The device properties are used along with a technology computer‐aided design to deduce the interface trap density quantitatively. The transfer characteristics are simulated using a double Gaussian density of states and fitted with experimental data by adding traps to the semiconductor dielectric interface. A typical transistor with SiO2 interface has shown an interface trap density of about ≈1016 cm−2, and it is reduced to 1014 cm−2 when poly(methyl)methacrylate or polystyrene is coated on SiO2 interface, attributed to the surface passivation. This approach provides a simple and accurate way to estimate the interfacial traps and offers the possibility to tune the device architecture and performance.
Design and implementation of a multi‐port bidirectional converter for electric vehicle applications
Authors: Malik Muhammad Zeeshan , Zhang Shiqing , Ali Amjad , Farooq Ajmal 
Published: May 2023

SummaryThis article proposes a new multi‐port bidirectional DC‐DC converter for electric vehicle (EV) usages. The recommended converter has the ability for step‐up and step‐down operating. The bidirectional power flow makes the proposed converter suitable for EV applications, where a storage unit is charged and discharged. The proposed converter has three ports (VHigh, VLow, and V2), and all of these ports have bidirectional features. In each operation mode (step‐up or step‐down), the output port is loaded by two independent input sources. Also, a high voltage conversion ratio is achieved with low power switches duty cycle and reduced peak voltage over semiconductors. Input current with reduced ripple, low components count, a simple circuit with low cost and volume, and high efficiency are the main advantages of the presented bidirectional topology. In order to demonstrate the performance and effectiveness of the recommended converter, operational and steady‐state analysis in step‐up and step‐down modes, design consideration, efficiency calculation, and comparison with other DC‐DC converters are provided Finally, a prototype with a step‐up power of 120 W and a step‐down power of 30 W is created, and experimental data are shown to validate the numerical investigations.