bluuebunny/crossref_metadata_2025_split huggingface dataset:
An mTOR feedback loop mediates the ‘flare’ (‘rebound’) response to MET tyrosine kinase inhibition
Authors: Altintas D. M. , Cerqua M. , De Laurentiis A. , Trusolino L. , Boccaccio C. , Comoglio P. M. 
Published: January 2023

AbstractTargeted therapy significantly impairs tumour growth but suffers from limitations, among which the ‘flare’ (‘rebound’) effect. Among cancers driven by tyrosine kinase receptors, those relying on alterations of the MET oncogene benefit from treatment by specific inhibitors. Previously, we reported that discontinuation of MET tyrosine kinase receptor inhibition causes ‘rebound’ activation of the oncogene, with a post-treatment transient hyperphosphorylation phase that culminates into a dramatic increase in cancer cell proliferation. The molecular mechanisms behind the ‘MET burst’ after treatment cessation are unknown but critically important for patients. Here we identify a positive feedback loop mediated by the AKT/mTOR pathway leading to (a) enhanced MET translation by activating p70S6K and 4EBP1 and (b) MET hyper-phosphorylation by inactivation of the tyrosine-phosphatase PTP1B. The latter effect is due to m-TOR-driven PTP1B phosphorylation of the inhibitory residues Ser50 and Ser378. These data provide in vitro evidence for the use of mTOR inhibitors to prevent the ’flare effect’ in MET targeted therapy, with potential applicative ramifications for patient clinical management.
Association between resilience and advance care planning during the COVID-19 pandemic in Japan: a nationwide cross-sectional study
Authors: Miyashita Jun , Takeshima Taro , Maehara Kazuhira , Hamaguchi Sugihiro , Fukuhara Shunichi 
Published: January 2023

AbstractAdvance care planning (ACP) is essential for end-of-life care, especially during the novel coronavirus disease 2019 (COVID-19) pandemic, and resilience is critical to deal with pandemic-related stressors. Therefore, we investigated the association between resilience ability and ACP discussions during the COVID-19 pandemic. A nationwide web-based survey was conducted in July 2021 in Japan. We analyzed the respondents’ ability to bounce back from stress (bouncing-back ability), positive stress coping (e.g., “seeking social support”, “planning”), and negative stress coping (e.g., “avoidance”, “alcohol and drug use”) in relation to ACP discussions using multivariable logistic regression models. In total, 2000 responses (86% participation rate) were received (mean age: 51.8 ± 16.7). Normal and high bouncing-back ability (adjusted odds ratio [AOR]: 1.69, 95% CI: 1.03–2.79; AOR: 2.07, 95% CI: 1.18–3.65, respectively) were significantly associated with the occurrence of ACP discussions. Seeking social support and planning were significantly associated with ACP discussions, whereas avoidance and alcohol and drug use were not. Both bouncing-back ability and positive stress coping were significantly associated with the occurrence of ACP discussions during the COVID-19 pandemic in Japan. These findings could be useful for aiding health-care providers involved in ACP discussions during the COVID-19 pandemic.
Modification of termination of resuscitation rule with compression time interval in South Korea
Authors: Park Song Yi , Lim Daesung , Ryu Ji Ho , Kim Yong Hwan , Choi Byungho , Kim Sun Hyu 
Published: January 2023

AbstractThis study aimed to validate the predictive performance of the termination of resuscitation (TOR) rule and examine the compression time interval (CTI) as a criterion for modifying the rule. This retrospective observational study analyzed adult out-of-hospital cardiac arrest (OHCA) patients attended by emergency medical service (EMS) providers in mixed urban–rural areas in Korea in 2020 and 2021. We evaluated the predictive performance of basic life support (BLS) and the Korean Cardiac Arrest Research Consortium (KoCARC) TOR rule using the false-positive rate (FPR) and positive predictive value (PPV). We modified the age cutoff criterion and examined the CTI as a new criterion. According to the TOR rule, 1827 OHCA patients were classified into two groups. The predictive performance of the BLS TOR rule had an FPR of 11.7% (95% confidence interval (CI): 5.9–17.5) and PPV of 98.4% (97.6–99.2) for mortality, and an FPR of 3.6% (0.0–7.8) and PPV of 78.6% (75.9–81.3) for poor neurological outcomes at hospital discharge. The predictive performance of the KoCARC TOR rule had an FPR of 5.0% (1.1–8.9) and PPV of 98.9% (98.0–99.8) for mortality, and an FPR of 3.7% (0.0–7.8) and PPV of 50.0% (45.7–54.3) for poor neurological outcomes at hospital discharge. The modified cutoff value for age was 68 years, with an area under the receiver operating characteristic curve over 0.7. In the group that met the BLS TOR rule, the cutoff of the CTI for death was not determined and was 21 min for poor neurological outcomes. In the group that met the KoCARC TOR rule, the cutoff of the CTI for death and poor neurological outcomes at the time of hospital discharge was 25 min and 21 min, respectively. The BLS TOR and KoCARC TOR rules showed inappropriate predictive performance for mortality and poor neurological outcomes. However, the predictive performance of the TOR rule could be supplemented by modifying the age criterion and adding the CTI criterion of the KoCARC.
Joint UAV deployment, SF placement, and collaborative task scheduling in heterogeneous multi‐UAV‐empowered edge intelligence
Authors: Wang Yangang , Wei Xianglin , Wang Hai , Fan Jianhua , Chen Juan , Zhao Kuang , Hu Yongyang 
Published: January 2023

AbstractTo support artificial intelligence (AI)‐involved tasks offloaded from the mobile devices (MDs), it is necessary to equip the Unmanned Aerial Vehicle (UAV) with custom‐made co‐processor (CP) for handling AI workloads in multi‐UAV‐empowered Edge Intelligence. Existing CPU‐oriented task scheduling algorithm cannot apply to the CPU+CP heterogeneous architecture. In this backdrop, this paper first formulates the joint service function placement, collaborative task scheduling, UAV deployment, and MD position determination problem as a Mixed Integer Non‐Linear Programming problem. Then, an alternating optimization‐based algorithm is put forward to derive a sub‐optimal solution of the problem utilizing Differential Evolution and Greedy‐based Hungarian algorithms. A series of experiments are conducted to evaluate the performance of the proposal. Results show that authors' proposal can achieve an overall revenue that is roughly 50% higher than those of existing methods.
A survey on reconfigurable intelligent surfaces: Wireless communication perspective
Authors: Hassouna Saber , Jamshed Muhammad Ali , Rains James , Kazim Jalil ur Rehman , Rehman Masood Ur , Abualhayja Mohammad , Mohjazi Lina , Cui Tei Jun , Imran Muhammad Ali , Abbasi Qammer H. 
Published: January 2023

AbstractUsing reconfigurable intelligent surfaces (RISs) to improve the coverage and the data rate of future wireless networks is a viable option. These surfaces are constituted of a significant number of passive and nearly passive components that interact with incident signals in a smart way, such as by reflecting them, to increase the wireless system's performance as a result of which the notion of a smart radio environment comes to fruition. In this survey, a study review of RIS‐assisted wireless communication is supplied starting with the principles of RIS which include the hardware architecture, the control mechanisms, and the discussions of previously held views about the channel model and pathloss; then the performance analysis considering different performance parameters, analytical approaches and metrics are presented to describe the RIS‐assisted wireless network performance improvements. Despite its enormous promise, RIS confronts new hurdles in integrating into wireless networks efficiently due to its passive nature. Consequently, the channel estimation for, both full and nearly passive RIS and the RIS deployments are compared under various wireless communication models and for single and multi‐users. Lastly, the challenges and potential future study areas for the RIS aided wireless communication systems are proposed.
H2 model order reduction of bilinear systems via linear matrix inequality approach
Authors: Nasiri Soloklo Hasan , Bigdeli Nooshin 
Published: January 2023

AbstractThis paper proposes an H2‐optimal model order reduction (MOR) method for bilinear systems based on the linear matrix inequality (LMI) approach. In this method, to reduce the computational complexity, at first, a reduced middle‐order approximation of the system is derived based on common bilinear MOR methods. Next, the H2 norm of the error system is minimized to obtain the reduced‐order bilinear model. Generalized Lyapunov equations are added to the optimization problem as LMI constraints to guarantee the specification of type II Gramians of the bilinear system to improve accuracy. Besides, two stability conditions are included to the optimization problem as its constraints to preserve stability of reduced‐order bilinear model. One of advantages of the proposed method is the need for only one of the Gramians of controllability or observability. Since the proposed H2‐optimal MOR problem is a polynomial matrix inequality (PMI) problem, an iterative method is used to convert the PMI to the LMI problems and solve the optimization problem. Three bilinear test systems are considered to show the proposed method's efficiency, while its performance is compared with some classical methods. Results show that the proposed methods lead to a more accurate reduced‐order model than other MOR methods.
Live line strain clamp's DR image anomaly detection based on unsupervised learning
Authors: Haoliang Zheng , Zhiwei Jia , Yuting Li , Rongjie Wang , Wenguang Zhou 
Published: January 2023

AbstractDue to the high‐risk working environment of high‐voltage transmission lines, defect samples of strain clamps cannot be fully and completely collected. As a result, the deep learning method based on defect sample tags cannot effectively identify all abnormalities. To solve this problem, an unsupervised anomaly detection method based on knowledge distillation is proposed, which only requires a small number of normal samples to drive the model for anomaly detection. ResNet is the framework of the teacherstudent model, and the feature activation layer after ResBlock is used for knowledge transfer. Residual‐assisted attention and pyramid‐splitting attention were used to enhance the spatial perception and multi‐scale information utilization ability of the model. This model only transmits the information of normal samples and is sensitive to abnormal samples. The proposed model outperformed the baseline by 23% and individual categories by 78% on the MVTec AD (Anomaly Detection Dataset) and outperformed the baseline by 45% and individual categories by 10% on the CIFAR10 and is also reliable for Mnist and Fashion Mnist. This method performs best (82.71%) over the existing method on the self‐built data set.
Segmenting lung parenchyma from CT images with gray correlation‐based clustering
Authors: Liu Caixia , Xie Wanli , Zhao Ruibin , Pang Mingyong 
Published: January 2023

AbstractLung segmentation, a prerequisite step of lung disease detection in computer‐aided diagnosis system, is a challenging task because of noises, complex structures, as well as large individual differences of lung CT scans. Here, an automatic algorithm for segmenting lungs from thoracic CT images accurately is presented. This scheme consists of three principal steps: image preprocessing, lung extracting and contour correcting. To cope with inhomogeneous intensities of CT images, a novel preprocessing approach based on empirical mode decomposition and bilateral filter is proposed, which has abilities of denoising, smoothing and edge keeping. Lung region is then extracted with a novel gray correlation‐based clustering approach. A new lung contour correction technology is finally employed to repair the concave regions caused by pulmonary nodules, vessels and so on. Experimental results show that the preprocessing approach outperforms other methods on image denoising and smoothing. Meanwhile, the lung segmentation algorithm is tested on a group of lung CT images affected with interstitial lung diseases and achieves a high segmentation accuracy. Compared with several existing lung segmentation methods, this algorithm exhibits a better performance on lung segmentation.
Miniaturised frequency selective surface‐based rasorber with wideband two‐sided absorption and switchable transmission/reflection band
Authors: Tang Min , Liu Qikun , Zhou Dongfang , Liu Qing , Yao Zhenning , Pan Chenqing 
Published: January 2023

AbstractA new rasorber with a switchable transmission/reflection band between two wide absorption bands is proposed based on an ultrathin low‐profile frequency selective surface. To miniaturise the periodicity in the lossy layer, convoluted elements and lumped capacitors are applied, while in the bandpass layer, non‐resonate elements are implemented with PIN diodes embedded. Moreover, a square loop loaded with resistors is introduced to the bottom of the lossy layer, which consequently extends the bandwidth of the high‐frequency absorption band without an increase in thickness. The simulation indicates that the proposed design presents a switchable transmission/reflection band in two‐sided absorption bands with a periodicity of 0.089λL (wavelength at the lowest operating frequency) and thickness of 0.066λL. Angular stability and polarisation insensitivity are also obtained due to the low profile and symmetry. A prototype was fabricated and measured, according to which the switchable transmission band covers 3.67–3.93 GHz; the absorption bands cover 2.37–3.23 GHz and 4.09–6.63 GHz in the OFF state of the diodes, and 2.23–3.02 GHz and 4.01–6.53 GHz in the ON state. As reasonable agreements between the measurement and simulation results are observed, the performance of the design is verified.
Design of wideband metamaterial absorber using circuit theory for X‐band applications
Authors: Zolfaghary pour Saeed , Chegini Ebrahim , Mighani Mojtaba 
Published: January 2023

AbstractA broadband metamaterial absorber working in the X‐band is designed and fabricated by 3D printing in this study. This structure is capable of nearly absorbing the power of incoming waves (more than 90%) in the frequency band starting from 7.1 to 13.8 GHz. This metamaterial absorber is designed based on an infinite array of conductive ribbons, and the thickness of the absorber is just 0.1λ for the minimum frequency (without considering the thickness of the ground layer). A circuit model and transmission line theory are used to design and explain the absorption principle of the proposed structure. Our novel design method is flexible and can be applied to other frequency bands. The satisfaction of the proposed absorber can be applied to many applications namely communication, electromagnetic shielding, radar and satellite. Furthermore, due to the flexibility of the substrate, the proposed absorber is also suitable for flexible applications in the X‐band.
Mini-moons from horseshoes: A physical characterization of 2022 NX1 with OSIRIS at the 10.4 m Gran Telescopio Canarias
Authors: de la Fuente Marcos R. , de León J. , de la Fuente Marcos C. , Licandro J. , Serra-Ricart M. , Cabrera-Lavers A. 
Published: January 2023

Context. The near-Earth orbital space is shared by natural objects and space debris that can be temporarily captured in geocentric orbits. Short-term natural satellites are often called mini-moons. Reflectance spectroscopy can determine the true nature of transient satellites because the spectral signatures of spacecraft materials and near-Earth asteroids (NEAs) are different. The recently discovered object 2022 NX1 follows an Earth-like orbit that turns it into a recurrent but ephemeral Earth companion. It has been suggested that 2022 NX1 could have an artificial origin or be lunar ejecta.
Aims. Here, we use reflectance spectroscopy and N-body simulations to determine the nature and actual origin of 2022 NX1.
Methods. We carried out an observational study of 2022 NX1, using the OSIRIS camera spectrograph at the 10.4 m Gran Telescopio Canarias, to derive its spectral class. N-body simulations were also performed to investigate how it reached NEA space.
Results. The reflectance spectrum of 2022 NX1 is neither compatible with an artificial origin nor lunar ejecta; it is also different from the V type of the only other mini-moon with available spectroscopy, 2020 CD3. The visible spectrum of 2022 NX1 is consistent with that of a K-type asteroid, although it could also be classified as an Xk type. Considering typical values of the similar albedo of both K-type and Xk-type asteroids and its absolute magnitude, 2022 NX1 may have a size range of 5 to 15 m. We confirm that 2022 NX1 inhabits the rim of Earth’s co-orbital space, the 1:1 mean-motion resonance, and experiences recurrent co-orbital engagements of the horseshoe-type and mini-moon events.
Conclusions. The discovery of 2022 NX1 confirms that mini-moons can be larger than a few meters and also that they belong to a heterogeneous population in terms of surface composition.
Lipohyperplasia dolorosa (LiDo): Renaming, prima vista Diagnose, Koinzidenz, Palpation und Resektion
Authors: Cornely Manuel 
Published: January 2023

ZusammenfassungDie seit 1940 bekannte Erkrankung „Lipedema“ wird zunehmend besser verstanden. Besonders ein dellbares Ödem ist bei der Fettverteilungsstörung der Frauen an Armen und Beinen nicht bedeutsam. Diese und weitere wissenschaftliche Erkenntnisse sind „work in progress“ mit dem Ziel des Renaming der Erkrankung. Ein „proper name“ ist „Lipohyperplasia dolorosa“ (LiDo). Bei LiDo ist die Volumenzunahme genetisch fixiert, der Schmerz jedoch dynamisch progredient.Eine LiDo muss von anderen symmetrischen, schmerzlosen Fettverteilungsstörungen an Armen und Beinen prima vista und nach palpatorischer Untersuchung, insbesondere von der gelegentlich koinzidenten Adipositas, unterschieden werden.Adipositas ist nie komorbid, aber häufig koinzident bei LiDo. Körperliche Aktivität und Ernährungsumstellung können zwar das Übergewicht reduzieren, nicht aber die ausschließlich LiDo-bedingte disproportionale Fettgewebsvermehrung an den Extremitäten beseitigen. Bei mit Adipositas koinzidenten LiDo-Patientinnen gibt es durch Magenchirurgie keine Effekte auf die obligate Schmerzhaftigkeit.Für LiDo gibt es sowohl konservative als auch operative Behandlungsmöglichkeiten. Ein seit 1997 etabliertes Verfahren ist die chirurgische Behandlung durch die Lymphologische Liposculptur. Im Rahmen dieser Operation entstehen unter der Haut große Wunden, die nach den „Rules of Nine“ bei Behandlung der beiden Arme in einer Sitzung und der Suktion der Beine in 2 Sitzungen pro Eingriff einer Fläche von 18% der body surface entsprechen. Durch ein adäquates postoperatives Management sowie die Gabe von Antibiotika und Antithrombotika kommt es dennoch nur selten zu operationsbedingten lokalen Komplikationen.Das wichtigste Ergebnis konsequenter operativer Behandlung der Lipohyperplasia dolorosa ist der Einfluss auf die Lebensqualität: „It ruined her life“ wird zu „It improves her life“.
A Modification of the Anoplasty Technique during a Posterior Sagittal Anorectoplasty and Anorectal Vaginal Urethroplasty Closure: The Para-U-Stitch to Prevent Wound Dehiscence
Authors: Knaus Maria E. , Westgarth-Taylor Christopher , Gasior Alessandra C. , Halaweish Ihab , Thomas Jessica L. , Srinivas Shruthi , Levitt Marc A. , Wood Richard J. 
Published: January 2023

Abstract
Objective Wound dehiscence after posterior sagittal anorectoplasty (PSARP) or anorectal vaginal urethroplasty (PSARVUP) for anorectal malformation (ARM) is a morbid complication. We present a novel anoplasty technique employing para-U-stitches along the anterior and posterior portions of the anoplasty, which helps buttress the midline U-stitch and evert the rectal mucosa. We hypothesized that, in addition to standardized pre- and postoperative protocols, this technique would lower rates of wound dehiscence.
Materials and Methods A retrospective review of patievnts who underwent primary PSARP or PSARVUP with the para-U-stitch technique from 2015 to 2021 was performed. Wound dehiscence was defined as wound disruption requiring operative intervention within 30 days of the index operation. Superficial wound separations were excluded. Descriptive statistics were calculated. The final cohort included 232 patients.
Results Rectoperineal fistula (28.9%) was the most common ARM subtype. PSARP was performed in 75% and PSARVUP in 25%. The majority were reconstructed with a stoma in place (63.4%). Wound dehiscence requiring operative intervention occurred in four patients, for an overall dehiscence rate of 1.7%. The dehiscence rate was lower in PSARPs compared with PSARVUPs (0.6 vs. 5.2%) and lower for reconstruction without a stoma compared with a stoma (1.2 vs. 2.0%). There were additional six patients (2.6%) with superficial wound infections managed conservatively.
Conclusion We present the para-U-stitch anoplasty technique, which is an adjunct to the standard anoplasty during PSARP and PSARVUP. In conjunction with standardized pre- and postoperative protocols, this technique can help decrease rates of wound dehiscence in this patient population.
Ethical Aspects of Prodromal Synucleinopathy Prognostic Counseling
Authors: Stefani Ambra , Mozersky Jessica , Kotagal Vikas , Högl Birgit , Ingravallo Francesca , Ju Yo-El S. , Avidan Alon , Sharp Richard , Videnovic Aleksandar , Schenck Carlos H. , St Louis Erik K. 
Published: January 2023

AbstractAlpha-synucleinopathies can be identified in their prodromal phase, raising several ethical issues. In this review, we first provide definitions of prodromal α-synucleinopathies and discuss the importance of distinguishing between prodromes and risk factors. Next, we discuss the implications of a diagnosis of prodromal α-synucleinopathy and considerations regarding prognostic counseling in both clinical and research settings. We review available data on patient preferences regarding disclosure as well as providers' perspectives. We examine the pros and cons of disclosing a diagnosis of prodromal α-synucleinopathy, taking into consideration the differences between clinical and research settings. Asking about willingness to know in clinical and research settings and the shared decision-making process applied to prognostic counseling is discussed. Concerning research settings, ethical aspects regarding clinical trials are addressed. Availability of direct-to-consumer technologies will likely lead to novel contexts requiring prognostic counseling, and future neuroprotective or neuromodulating treatments may require further considerations on the timing, role, and importance of prognostic counseling. Recommendations on how to address ethical gaps should be a priority for patients, medical professional societies, and research workgroups. Ethical issues must be considered as an integral part of the overall clinical and research approach to prodromal synucleinopathies.