bluuebunny/crossref_metadata_2025_split huggingface dataset:
No Increased Risk of Nonunion with Bisphosphonate Use in a Medicare Claims Cohort Following Operatively Treated Long-Bone Fractures
Authors: Thorne Tyler J. , Steffenson Lillia , O’Neill Dillon C. , Marchand Lucas S. , Martin Brook I. , Haller Justin M. 
Published: February 2023

Background:
The diagnosis of a fragility fracture represents an important intervention event for the initiation of medical osteoporosis treatments. However, it is unclear if osteoporosis medications increase the risk of nonunion if administered in the setting of acute fracture. The purpose of the present study was to investigate whether bisphosphonates or selective estrogen receptor modulators/hormone replacement therapy (SERM/HRT) are associated with nonunion following fracture in a Medicare population.

Methods:
A retrospective analysis of Medicare claims from 2016 to 2019 was performed to identify patients ≥65 years of age who had a surgically treated long-bone fracture as identified with Current Procedural Terminology (CPT) codes and International Classification of Diseases, 10th Revision (ICD-10) codes. Successive claims were linked for each beneficiary through 1 year following the fracture to determine fracture union status. Multivariable logistic regression models were specified to identify the association between medications and fracture union status while controlling for age, sex, race, Charlson Comorbidity Index (CCI), and fracture type.

Results:
Of the 111,343 included fractures, 10,452 (9.4%) were associated with a diagnosis of nonunion within 1 year. The nonunion group was younger (79.8 ± 8.3 versus 80.6 ± 8.4 years; p < 0.001), more likely to be White (92.4% versus 90.9%; p < 0.001), and more likely to have a CCI of ≥2 (50.9% versus 49.4%; p < 0.001). Bisphosphonate use was more common in the nonunion group (12.2% versus 11.4%; p = 0.017). When controlling for race, age, sex, and CCI, neither bisphosphonates (OR, 1.06 [95% CI, 0.99 to 1.12]; p = 0.101) nor SERM/HRT (OR, 1.13 [0.93 to 1.36]; p = 0.218) were associated with nonunion. Bisphosphonate use within 90 days post-fracture was not significantly associated with nonunion (OR, 0.94 [95% CI, 0.86 to 1.03]; p = 0.175), and the timing of medication administration did not influence fracture union status.

Conclusions:
The rate of nonunion after operatively treated long-bone fractures was 9.4%. In this cohort, use of a bisphosphonate or SERM/HRT was not associated with fracture union status at 1 year. Orthopaedic surgeons should not withhold or delay initiating medical therapies for osteoporosis in the setting of acute fracture out of concern for nonunion.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Actitudes hacia el uso del condón y uso del condón en adultos mayores residentes de Monterrey Nuevo León, México
Authors: Gómez-Melasio Dafne Astrid , Onofre-Rodríguez Dora Julia , Trujillo-Hernández Pedro Enrique , Rodríguez-Vázquez Nancy , Hernández-Torres José Luis , Lara-Reyes Braulio Josué 
Published: February 2023

Introducción: El uso del condón es efectivo para prevenir Infecciones de Transmisión Sexual. Se han identificado cifras bajas de uso en adultos mayores. Lo cual puede ser atribuible a diversas actitudes negativas.
Objetivo: Conocer las actitudes hacia el uso del condón, la relación que existe entre estas y las características sociodemográficas, y entre el uso del condón en el último encuentro sexual en adultos mayores.
Métodos: Estudio correlacional conformado por 110 adultos mayores residentes de Monterrey, Nuevo León. Se empleo un muestreo virtual.
Resultados: Se encontraron actitudes negativas de los efectos sobre la experiencia sexual, promiscuidad e inhibición en una cuarta parte de los participantes. Y actitudes positivas en las actitudes globales, el impacto interpersonal y la relación segura en la mayoría de los participantes. Se encontró asociación entre estado civil y efectos sobre la experiencia sexual (p = 0,012). No se encontró asociación entre el uso del condón en el último encuentro sexual y las actitudes.
Conclusión: Se encontraron más actitudes positivas que negativas, situación que no es congruente con la baja frecuencia de uso del condón en el último encuentro sexual, reflejando la importancia de futuras investigaciones que permitan explorar otros factores involucrados para el desarrollo de la conducta.
Macroeconomic Factors and the Prospects of Economic Prosperity in a Developing Economy: Evidence from Dynamic ARDL Simulations and KRLS Techniques
Authors: Aladejare Samson Adeniyi 
Published: February 2023

Abstract
This study simulated the counterfactual shock effects of inflation and exchange rates on economic prosperity (measured by GDP per capita) when considering deficit financing, foreign investment, and financial development for Nigeria from 1970 to 2020. Empirical inferences were derived by applying the novel dynamic ARDL and the Kernel regularised least squares models. Applying both techniques enabled the response of economic prosperity to future counterfactual shocks to the inflation and exchange rate variables. It was observed that inflationary shocks might have long-term beneficial effects on economic prosperity; however, shocks to the exchange rate will erode these benefits. Findings also showed that inflation rate and deficit financing adversely impacted short and long-term economic wealth. Contemporaneously, the exchange rate and financial development only benefited economic prosperity in the long term, while foreign investment was ineffectual. The study also proposed several policy measures.
Anisotropic resistance with a 90o twist in a ferromagnetic Weyl semimetal, Co2MnGa
Authors: Quirk Nicholas , Cheng Guangming , Manna Kaustuv , Felser Claudia , Yao Nan , Ong N. Phuan 
Published: February 2023

Abstract
Co2MnGa is a ferromagnetic semimetal with Weyl nodal lines identified by ARPES. We studied electrical transport in thin Co2MnGa lamellae (10 x 10 x 0.4-5 μm) cut from single-crystals using a focused ion beam. These crystals exhibit an unexpected and highly unusual planar resistance anisotropy (10X) with principal axes that rotate by 90o between the upper and lower faces. Using symmetry arguments and simulations, we find that the observed resistance anisotropy resembles that of an isotropic conductor with anisotropic surface states that are impeded from hybridization with bulk states. The origin of these states awaits further experiments that can correlate the surface bands with the observed 90o-twist geometry.
Photodegradation of 17α-ethinylestradiol on Ag3PO4 crystals treated at different temperatures
Authors: Noleto Luis F. G. , Vieira Vitória E. M. , Lopes Francisco H. P. , Ribeiro Lara K. , Dantas Taisa C. M. , Gusmão Gustavo O. M. , Luz Geraldo E 
Published: February 2023

Abstract
The incorrect disposal of medicines can trigger an imbalance in the ecosystem of rivers and lakes, as well as human and animal health. Therefore, the heterogeneous photocatalysis technique is a promising technology to minimize or even eliminate these pollutants from aquatic systems. Silver phosphate crystals (Ag3PO4) have excellent photocatalytic and bactericidal properties. For the synthesis of crystals of silver phosphate, the method of preparation used was precipitation at room temperature, followed by heat treatment at 100, 200, 300, 400, and 500 ºC for six h. The X-ray Diffraction data show structures with excellent crystallinity, remaining even after temperature variation. Scanning electron microscopy images exhibited a variation in the morphology of the materials with increasing temperature. Diffuse reflectance spectroscopy revealed the materials optical band energy values ranging from 2.33 to 2.41 eV. On the other hand, the Raman and Infrared spectra showed a reduction in the bands referring to the phosphate groups. The Ag3PO4 crystals heat treated at 200 and 500 ºC showed the better performance for the photodegradation of 17α-ethinylestradiol (EE2) with highest kinetic constant (7.42x10− 3 min− 1) and TOF (3.11x10− 4 min − 1) values for photocatalyst test carried out on crystals heat treated at 200 ºC.
Hypnosis to reduce fear of falling in hospitalized older adults: a pilot randomized controlled trial.
Authors: Cuvelier Clémence , Hars Mélany , Zamorani-Bianchi Maria Pia , Herrmann Francois R. , Wieczorkiewicz Catherine Ducharne , Zekry Dina , Gold Gabriel , Trombetti Andrea 
Published: February 2023

Abstract
Background: Fear of falling is associated with numerous negative health outcomes in older adults and can limit the rehabilitation process. Hypnosis is now recognized as an effective treatment for a variety of conditions, especially anxiety and pain, which can be integrated safely with conventional medicine. The objective of this study was to assess the feasibility and acceptability of a hypnosis intervention in hospitalized older adults to reduce fear of falling.
Methods: In this pilot feasibility randomized controlled trial, thirty-two older patients, hospitalized in geriatric rehabilitation wards, were randomly allocated (1:1 ratio) to either an intervention group (hypnosis, 2 sessions, one per week, plus usual rehabilitation program) or a control group (usual rehabilitation program only). Clinical assessors and statistician were blinded to group allocation. Primary outcomes were recruitment rate, retention rate and adherence to the intervention. Exploratory outcomes, analyzed according to the intention-to-treat principle, included impact of hypnosis on fear of falling (assessed by a new scale perform-FES), functional status, in-hospital falls, and length of hospital stay.
Results: Of the 57 patients screened, 32 were randomized: 15 in the intervention group and 17 in the control group. Recruitment rate was 1.3 patients per week. The recruitment of the population sample was achieved in 5.5 months. The retention rate did not differ significantly between groups and a good adherence to the hypnosis intervention was achieved (77% of patients received the full intervention). No adverse event related to the hypnosis intervention was observed. Regarding exploratory clinical outcomes, no differences were found between groups on any outcome.
Conclusion: Hypnosis is feasible and well accepted in a geriatric hospitalized population undergoing rehabilitation. Further pilot work should be conducted, with an increased number of hypnosis sessions, before conducting a full-scale trial to conclude whether or not hypnosis is effective to reduce fear of falling.
Trial registration: ClinicalTrials.gov, NCT04726774. Registered 27 january 2021, retrospectively registered, https://clinicaltrials.gov/ct2/show/record/NCT04726774
Funding: Geneva University Hospitals, Research and Development Project (9-2018-I)
Technical and Economical Assessment of the Treatment of Vinasse from Pisco Production Using the Advanced Oxidation Process
Authors: Poblete Rodrigo , Bakit José 
Published: February 2023

Abstract
The removal of organic matter from Pisco production wastewater was evaluated using coagulation/flocculation, filtration as a pre-treatment and solar photo-Fenton, with the use of two types of photoreactors: compound parabolic collectors (CPC) and flat plate (FP), with and without utilising the ozonation process. The overall removal efficiency for COD was 63% and 15% using FP and CPC, respectively. Also, for the overall removal efficiency of polyphenols, a percentage of 73% and 43% were obtained using FP and CPC, respectively. When ozone was used in the solar photoreactors, the resulting trends were similar. COD and polyphenol removal, using an FP photoreactor in the solar photo-Fenton/O3 process, resulted in values of 98.8% and 86.2% after the process. COD and polyphenol removal, using solar photo-Fenton/O3 process in a CPC, resulted in values of 49.5% and 72.4%, respectively. The economic indicators of annual worth and economic treatment capacity established that FP reactors represent lower costs than CPCs. These results were corroborated by the economic analyses of the evolution of costs versus COD removed as well as by the cash flow diagrams projected for 5, 10 and 15 years.
Circulating tumor cells in ovarian cancer patients as a cellular marker for early detection of ovarian cancer in asymptomatic patients
Authors: Sheleby Mohammed Hussein , Sanoh Noura E. , Gad Mohammed Salama , Alhalaby Alaaeldein Fathallah , Salem Mohamed Labib 
Published: February 2023

Abstract
Purpose
Ovarian cancer (OC) is the leading cause of death among gynecologic cancers worldwide. The aim of this study was to identify and enumerate circulating tumor cells (CTCs) in OC patients and correlate their numbers with the clinical outcomes.
Methods
we enrolled patients diagnosed with suspected OC based on history, ultrasound criteria, and tumor markers. Complete clinical examination, abdominal and pelvic ultrasonography, serum CA125, and risk of malignancy index (RMI) were recorded. The percentage of CTCs was analyzed using flow cytometry based on the following phenotypes CD105+, CD24+, CD117+, and Epcam+.
Results
CTCs were found in 100% of patients with primary OC and no CTCs were found in secondary or borderline OC. The mean of CTC numbers in all patients was 0.12 ± 0.11 cells/µl. The highest number of CTCs was observed among the malignant patients; A highly statistically significant (p-value < 0.001) positive correlation (r = 0.55) was found between CTCs and FIGO, between CTCs and RMI (r = 0.53; p-value < 0.001), and CTCs and CA-125 (r = 0.42; p-value < 0.001). The CTCs count allowed to distinguish between early and late FIGO stage at a cutoff level of > 0.82 cells/µl, with 66.7% sensitivity, 90.9% specificity, 88% PPV and 73.2% NPV (AUC = 0.65 & p-value = 0.076).
Conclusion
CTCs can be used as a cellular marker for the early detection of OC.
Increased expression and immune cell infiltration of E2F1/2 collerate with better prognosis in thyroid cancer
Authors: chen han 
Published: February 2023

Abstract
Purpose: This study aimed to explore the expression of E2Fs gene family in thyroid cancer(THCA) patients, and systematically analyze the relationship between E2Fs gene and immune cell infiltration and prognosis of THCA patients. Methods: We utilized the UALCAN, cBioPortal, Kaplan-Meier Plotter, Human Protein Atlas, GEPIA, Metascape, Linkedomics and TIMER online databases to explore the transcription level, protein level, genetic alteration and the biological functions of E2Fs, and its relationship with the prognosis and infiltration of immune cell in thyroid cancer patients.
Results: ① The expressions of E2F1/7 were significantly increased in the tumor group, while the expressions of E2F4/5 were greatly decreased. ②The mutation rate of E2Fs was 32.93% in patients with THCA, and the mutation of E2Fs was significantly associated with shorter disease-specific survival (P=0.0187) and progression-free survival (P=0.0147). ③Higher expression in transcription and protein levels of E2F1 (HR=0.15, 95%CI: 0.05-0.47, P=0.00015) and E2F2 (HR=37, 95%CI: 0.14-1.00, P= 0.041) were significantly associated with longer overall survival of THCA patients. ④The expression level of E2F1 was positively correlated with infiltration of B cells (Cor = 0.156, p =5.69e-4) and CD8+ T cells (Cor = 0.096, p = 3.35e-2). The expression level of E2F2 was positively correlated with infiltration of B cells (Cor = 0.433, p =2.01e-2), CD8+ T cells (Cor = 0.296, p =2.55e-11), CD4+ T cells (Cor = 0.213, p =1.97e-6), Macrophages (Cor = 0.277, p =4.94e-10), neutrophils (Cor = 0.362, p =1.35e-16) and dendritic cells (Cor = 0.479, p =3.98e-29).
Conclusions: E2F1/2 were potential the prognostic markers of THCA patients. Their functions may be related to cell cycle and DNA replication signaling pathways, and promoting multiple immune cell infiltration.
Multidimensional Intelligences Model as a predictor for coming out acceptance and growth among LGB non-migrant Hispanics: A pilot study
Authors: Esteban Caleb , Ramos-Pibernus Alixida , González-Rivera Juan A. , Mattei-Torres Edna , Hernández-López Eddiel 
Published: February 2023

Abstract

The coming out process has biopsychosocial components that occur whenever a lesbian, gay or bisexual (LGB) person shares their sexual orientation with another person. It is a complex and difficult process, but it has been described as an essential component for identity formation and integration. The purpose of this pilot study was to assess a Multidimensional Intelligences Model (MIM) (Body, Emotional, Social, and Ecological Intelligences) as predictor of the coming out acceptance (COA) and growth (COG).The objectives of this study were to 1) examine if MIM can predict COA and COG among LGB individuals; and 2) determine differences in the MIM between the four stratified groups (lesbian women, bisexual women, gay men, bisexual men). This pilot study had a quantitative method with an exploratory cross-sectional design. A total of 67 LGB participants completed an online survey. The results shows that the MIM could not predict the COA. However, the MIM could predict the COG and explained 20.6% of the variance. We believe this can be explained because in the COA people do not have control of how other people can feel and react. However, in the COG the person could have full self-control of their own growth.
PCR-Based Detection of the Honeybee Tracheal Mite (Acarapis woodi) in Türkiye
Authors: AKPINAR Rahşan KOÇ , SEVİM Ali , Sevim Elif , KAYA Selma , TÜRLEK Şakir Önder , AYDIN Coşkun , KARAOĞLU Şengül Alpay , ÇELİK Sema Nur , BOZDEVECİ Arif , GÜVEN Gökhan , KÜÇÜKOĞLU Bilal , Yaldız Murat , AYDIN İsmail 
Published: February 2023

Abstract
Acarapis woodi (Rennie, 1921) (Acari: Tarsonemidae) is one of the mites that settles in the respiratory system of honeybees (Apis mellifera L. (Hymenoptera, Apidae)) and distributed throughout the world. It causes significant economic losses on honey production. In Türkiye, studies on the existence of A. woodi are very limited and so far, no studies on the molecular diagnosis and phylogenetic of it have been reported in Türkiye. This study was conducted to investigate the prevalence of A. woodi in Türkiye, especially in areas where beekeeping is intense. Diagnosis of A. woodi was performed using both microscopic and molecular methods using specific PCR primers. Adult honeybee samples were collected from 1.193 hives in 40 provinces of Türkiye between 2018 and 2019. Based on identification studies, the presence of A. woodi was detected in a total of 3 hives (0.5%) in 2018 and 4 hives (0.7%) in 2019. This is the first report for determination of A. woodi in Türkiye.
Biowaste derived sustainable carbon aerogels/polyvinylidene fluoride composites for effective removal of organic pollutants/oils
Authors: Zhu Lin , Zheng Wenjing , Xie Hongbo , Zhang Kan 
Published: February 2023

Abstract
The sustainable low cost carbon aerogels (CA) derived from biowaste have wide application prospects in the environment and energy field. Due to the inherent fragility, the practical application of CA in removal of pollutants is limited. To address this issue, polyvinylidene fluoride (PVDF) was introduced into CA which was derived from pomelo peels. The CA/PVDF composites were prepared with solvent exchange by soaking CA in PVDF solutions with different concentrations. The influence of PVDF solution concentration on the internal morphology and hydrophobicity of the CA/PVDF composites were investigated. Static adsorption experiments showed that CA/PVDF composites had good adsorption ability for many common organic solvents and oils, and the adsorption ability decreased with the increase of the concentration of PVDF. The adsorption-desorption-regeneration cycle experiments showed that CA/PVDF composites had good reuse and regeneration. In addition, the adsorption properties of CA/PVDF composites as an adsorbent on phenol in aqueous solution were appraised. The results indicated that the kinetic data of the adsorption process was well described by the pseudo-second-order kinetic model, and the experimental equilibrium data fitted well with the Langmuir isotherm model with the maximum adsorption capacity of 13.09 mg/g.
Long-term treatment by mepolizumab reduces the relapse rate in patients with eosinophilic granulomatosis with polyangiitis
Authors: Masumoto Nami , Oshikata Chiyako , Nakadegawa Ryo , Motobayashi Yuto , Osada Reeko , Manabe Saki , Kaneko Takeshi , Tsurikisawa Naomi 
Published: February 2023

Abstract
Background: The mainstay of treatment for eosinophilic granulomatosis with polyangiitis (EGPA) is systemic corticosteroid therapy; some patients also receive intravenous immunoglobulins, other immunosuppressive agents, and biologics. Mepolizumab, an anti-interleukin-5 monoclonal antibody, in EGPA patients induces remission and decreases the daily dose of corticosteroids; however, the prognosis of long-term mepolizumab treatment for EGPA and its clinical efficacy are unknown.
Methods: Seventy-one EGPA patients were treated at Hiratsuka City Hospital, Japan, between April 2018 and March 2022. We administered mepolizumab for mean 2.8±1.7 years to 43 patients in whom remission could not be induced by conventional treatment. After excluding 18 patients who received mepolizumab for less than 3 years, we classified 15 patients in the “super-responder group” (the daily dose of corticosteroids or another immunosuppressant could be decreased, or the interval between IVIG treatments could be prolonged) and 10 patients in the “responder group” (neither of these changes could be achieved). Eosinophil numbers, serum IgG levels, daily doses of corticosteroids and other immunosuppressants, the Birmingham Vasculitis Activity Score (BVAS), and relapse frequency before and after mepolizumab initiation were determined.
Results: Eosinophil numbers at diagnosis or the lowest serum IgG level before mepolizumab treatment were higher in the super-responder group than in the responder group (p < 0.05). In the super-responder group, the prednisolone dose at last visit after mepolizumab initiation was lower than before treatment (p < 0.01) and in the responder group (p < 0.01). In both groups, the number of peripheral blood eosinophils and BVAS decreased after starting mepolizumab compared to before treatment (P < 0.01). BVAS before mepolizumab (p < 0.05) and at the last visit (p < 0.01) in the super-responder group were lower than in the responder group. Relapse rates every year after the start of mepolizumab were lower in the super-responder group than in the responder group (p <0.01). Relapse rates decreased during the 3 years following initiation of mepolizumab treatment (p <0.05) and at the last visit (p <0.01) compared with those at the start of mepolizumab treatment.
Conclusions: Treatment with mepolizumab in the super-responder group durably reduced the relapse rate.
Dynamical control enables the formation of demixed biomolecular condensates
Authors: Pappu Rohit , Lin Andrew , Ruff Kiersten , Jalihal Ameya , Dar Furqan , King Matthew , Lalmansingh Jared , Posey Ammon , Seim Ian , Gladfelter Amy 
Published: February 2023

Abstract
Macromolecular phase separation underlies the regulated formation and dissolution of biomolecular condensates. What is unclear is how condensates of distinct and shared macromolecular compositions form and coexist within cellular milieus. Here, we use theory and computation to establish thermodynamic criteria that must be satisfied to achieve compositionally distinct condensates. We applied these criteria to an archetypal ribonucleoprotein condensate and discovered that demixing into distinct protein-RNA condensates cannot be the result of purely thermodynamic considerations. Instead, demixed, compositionally distinct condensates arise due to asynchronies in timescales that emerge from differences in long-lived protein-RNA and RNA-RNA crosslinks. This type of dynamical control is also found to be active in live cells whereby asynchronous production of molecules is required for realizing demixed protein-RNA condensates. We find that interactions that exert dynamical control provide a versatile and generalizable way to influence the compositions of coexisting condensates in live cells.