bluuebunny/crossref_metadata_2025_split huggingface dataset:
A frequency‐dependent high‐cycle fatigue damage model and its application in crack nucleation of marine riser from corrosion pits
Authors: Yin Zhiming , Li Zhong , Longchi Zhou , Wang Yichao , Huang Xiaoguang 
Published: January 2023

AbstractBased on the continuum damage mechanics theory, a frequency‐dependent high‐cycle fatigue damage evolution model was established. According to the fatigue results of API X80 steel, the frequency‐dependent damage evolution parameters were regressed. Using the available riser mechanical model, the user subroutine of high‐cycle fatigue damage evolution was compiled, and the accelerating effect of corrosion pits on fatigue crack initiation of the marine riser was analyzed. The results show that a single corrosion pit at the surface can reduce crack nucleation life by more than 80%. In a double corrosion pits' case, the stress interference between pits significantly affects the crack nucleation. Circumferential double pits can produce a fatigue crack earlier than the single pit, but the effect of axial double pits is just the opposite. When the spacing reaches a certain distance, the stress interference disappears, and the crack nucleation life approaches that of a single pit case.
Rise of toxic cyanobacterial blooms is promoted by agricultural intensification in the basin of a large subtropical river of South America
Authors: Kruk Carla , Segura Angel , Piñeiro Gervasio , Baldassini Pablo , Pérez‐Becoña Laura , García‐Rodríguez Felipe , Perera Gonzalo , Piccini Claudia 
Published: January 2023

AbstractToxic cyanobacterial blooms are globally increasing with negative effects on aquatic ecosystems, water use and human health. Blooms' main driving forces are eutrophication, dam construction, urban waste, replacement of natural vegetation with croplands and climate change and variability. The relative effects of each driver have not still been properly addressed, particularly in large river basins. Here, we performed a historical analysis of cyanobacterial abundance in a large and important ecosystem of South America (Uruguay river, ca 1900 km long, 365,000 km2 basin). We evaluated the interannual relationships between cyanobacterial abundance and land use change, river flow, urban sewage, temperature and precipitation from 1963 to the present. Our results indicated an exponential increase in cyanobacterial abundance during the last two decades, congruent with an increase in phosphorus concentration. A sharp shift in the cyanobacterial abundance rate of increase after the year 2000 was identified, resulting in abundance levels above public health alert since 2010. Path analyses showed a strong positive correlation between cyanobacteria and cropland area at the entire catchment level, while precipitation, temperature and water flow effects were negligible. Present results help to identify high nutrient input agricultural practices and nutrient enrichment as the main factors driving toxic bloom formation. These practices are already exerting severe effects on both aquatic ecosystems and human health and projections suggest these trends will be intensified in the future. To avoid further water degradation and health risk for future generations, a large‐scale (transboundary) change in agricultural management towards agroecological practices will be required.
Survival and cognitive deterioration in elderly patients undergoing hemodialysis
Authors: Miyazaki Sayaka , Kitamura Mineaki , Hayashida Masatoshi , Tamaki Akira , Tomura Hideyuki , Yamaguchi Kosei , Nishino Tomoya , Funakoshi Satoshi 
Published: January 2023

AimThis study aimed to elucidate the 5‐year changes in the cognitive function of elderly patients undergoing hemodialysis and its association with survival and related factors.MethodsCognitive function in patients aged ≥65 years undergoing hemodialysis at the Nagasaki Renal Center was assessed using the Mini‐Mental State Examination (MMSE) in 2016. Patients were subsequently classified into normal, mild cognitive impairment (MCI) and suspected dementia groups according to their scores; MMSE was conducted at 30 and 60 months thereafter. The patients were followed until 2021. The association between survival and patient backgrounds was analyzed.ResultsOf the 181 patients, 168 completed follow‐up and were classified into normal (n = 71, 42.3%), MCI (n = 44, 26.1%), and suspected dementia (n = 53, 31.5%) groups. Multivariable logistic regression analysis showed that age, female sex, and geriatric nutritional risk index were associated with MMSE scores <24. The 5‐year survival rates were 60.6%, 40.9%, and 22.6% in the normal, MCI and suspected dementia groups, respectively. With some exceptions, MMSE results tended to decline during the observation period. A multivariate Cox proportional hazards model showed that age (hazard ratio [HR], 1.04; P = 0.007), dialysis vintage (HR, 0.96; P = 0.04), male sex (HR, 1.77; P = 0.02), geriatric nutritional risk index (HR, 0.94; P < 0.001) and MMSE score (HR, 0.96; P = 0.01) were independent risk factors for patient survival.ConclusionsCognitive impairment in patients undergoing hemodialysis was associated with age and nutritional status. Patients with cognitive impairment had a poor prognosis. Geriatr Gerontol Int 2023; 23: 111–116.
Association between COVID‐19 and consistent mask wearing during contact with others outside the household—A nested case–control analysis, November 2020–October 2021
Authors: Tjaden Ashley H. , Edelstein Sharon L. , Ahmed Naheed , Calamari Lydia , Dantuluri Keerti L. , Gibbs Michael , Hinkelman Amy , Mongraw‐Chaffin Morgana , Sanders John W. , Saydah Sharon , Plumb Ian D. ,   the COVID‐19 Community Research Partnership Study Group
Published: January 2023

AbstractBackgroundFace masks have been recommended to reduce SARS‐CoV‐2 transmission. However, evidence of the individual benefit of face masks remains limited, including by vaccination status.MethodsAs part of the COVID‐19 Community Research Partnership cohort study, we performed a nested case–control analysis to assess the association between self‐reported consistent mask use during contact with others outside the household and subsequent odds of symptomatic SARS‐CoV‐2 infection (COVID‐19) during November 2020–October 2021. Using conditional logistic regression, we compared 359 case‐participants to 3544 control‐participants who were matched by date, adjusting for enrollment site, age group, sex, race/ethnicity, urban/rural county classification, and healthcare worker occupation.ResultsCOVID‐19 was associated with not consistently wearing a mask (adjusted odds ratio [aOR] 1.49; 95% confidence interval [CI] [1.14, 1.95]). Compared with persons ≥14 days after mRNA vaccination who also reported always wearing a mask, COVID‐19 was associated with being unvaccinated (aOR 5.94; 95% CI [3.04, 11.62]), not wearing a mask (aOR 1.62; 95% CI [1.07, 2.47]), or both unvaccinated and not wearing a mask (aOR 9.07; 95% CI [4.81, 17.09]).ConclusionsOur findings indicate that consistent mask wearing can complement vaccination to reduce the risk of COVID‐19.
Social positioning matters: A socialized affordance perspective ofmHealthin India
Authors: Pandey Priyanka , Zheng Yingqin 
Published: January 2023

AbstractExisting research on technology affordance rarely considers the role of social structures in shaping the interaction between human actors and technology. In this paper, we draw upon the concept of social positioning to explore how socialized affordances of technology adoption, as well as their impact in work and social life, are shaped by the social positions that human actors occupy within multiple social structures. We do so by examining the adoption of mHealth devices by community health workers in India. The study generates theoretical implications for research on affordances of technology and social structures by integrating social positioning of actors in the analysis of a digital practice, and enriching IS research by incorporating the broader social arrangements and power relations.
Exploration of barriers to screening for domestic violence in the perinatal period using an ecological framework
Authors: Usanov Christina , Keedle Hazel , Peters Kath , O'Reilly Rebecca 
Published: January 2023

AbstractAimsTo explore Australian healthcare providers' perspectives on factors that influence disclosure and domestic violence screening through the lens of Heise's (1998) integrated ecological framework.DesignThis paper reports the findings that were part of a sequential mixed methods study with survey data informing interview questions. Participants for interviews were recruited after expressing an interest after completing surveys, as well as via snowball sampling.MethodsSemi‐structured interviews were undertaken in 2017 with 12 practicing healthcare providers delivering care to women in the perinatal period in Greater Western Sydney, NSW, Australia. Data were analysed using Braun and Clarke's (2006) six‐step thematic approach.FindingsThe findings were framed within Heise's integrated ecological framework under four main themes. The main themes were ‘Ontogenic: Factors preventing women from disclosing’; ‘Microsystem: Factors preventing healthcare providers from asking’; ‘Exosystem: Organizational structures not conducive to screening’; and ‘Macrosystem: Cultural attitudes and socioeconomic influences affecting screening’.ConclusionOrganizational policies are needed for better systems of reminding healthcare providers to enquire for domestic and family violence and mandating this within their practices. Mandatory domestic and family violence education and training that is suitable for the time constraints and learning needs of the healthcare provider is recommended for all healthcare providers caring for perinatal women. Further research is needed in addressing culturally specific barriers for healthcare providers to enquire about domestic and family violence in a culturally appropriate way.Public and Patient Engagement and Involvement in Research (PPEI)No Patient or Public Contribution was embedded into the research reported in this paper as this research was specifically exploring healthcare providers’ perspectives on domestic violence screening within their own practice experience.
How to Argue about Solar Geoengineering
Authors: Clark Britta 
Published: January 2023

ABSTRACTShould high‐income countries engage in solar geoengineering research and possible deployment? On the assumption that the speed of the energy transition will be insufficient to abate catastrophic climate impacts, research into solar geoengineering begins to look like a technically and socially feasible route to mitigate such impacts. But on the assumption that a rapid and relatively just energy transition is still within the realm of political possibility, research into solar geoengineering looks more like an ideological tool designed to divert time and resources from less risky climate solutions. At the heart of debates over solar geoengineering, then, is disagreement over what political actors can be expected to do in the future. In this article, I argue that both objectors to and proponents of solar geoengineering research often make background assumptions regarding expected future actions that are either (a) inaccurate or (b) inconsistent. I propose an account of expected future actions that avoids these problems and sketch what the debate over solar geoengineering looks like with these assumptions in place.
The transition zone in Hirschsprung's bowel contains abnormal hybrid ganglia with characteristics of extrinsic nerves
Authors: Smith Megan , Chhabra Sumita , Shukla Rajeev , Kenny Simon , Almond Sarah , Edgar David , Wilm Bettina 
Published: January 2023

AbstractThe aganglionic bowel in short‐segment Hirschsprung's disease is characterized both by the absence of enteric ganglia and the presence of extrinsic thickened nerve bundles (TNBs). The relationship between the TNBs and the loss of enteric ganglia is unknown. Previous studies have described decreasing numbers of ganglia with increasing density of TNBs within the transition zone (TZ) between ganglionic and aganglionic gut, and there is some evidence of spatial contact between them in this region. To determine the cellular interactions involved, we have analysed the expression of perineurial markers of TNBs and enteric ganglionic markers for both neural cells and their ensheathing telocytes across four cranio‐caudal segments consisting of most proximal ganglionic to most distal aganglionic from pull‐through resected colon. We show that in the TZ, enteric ganglia are abnormal, being surrounded by perineurium cells characteristic of TNBs. Furthermore, short processes of ganglionic neurons extend caudally towards the aganglionic region, where telocytes in the TNB are located between the perineurium and nerve fibres into which they project telopodes. Thus, enteric ganglia within the TZ have abnormal structural characteristics, the cellular relationships of which are shared by the TNBs. These findings will help towards elucidation of the cellular mechanisms involved in the aetiology of Hirschsprung's disease.
The association between respiratory diseases and periodontitis: A systematic review and meta‐analysis
Authors: Molina Ana , Huck Olivier , Herrera David , Montero Eduardo 
Published: January 2023

AbstractAimTo evaluate (1) whether periodontitis has an influence on the prevalence/incidence of respiratory diseases (chronic obstructive pulmonary disease [COPD], asthma, community‐acquired pneumonia [CAP], obstructive sleep apnoea [OSA] and COVID‐19), and (2) what is the impact of periodontal therapy on the onset or progression of respiratory diseases.Materials and MethodsAn electronic search was performed on Pubmed, Cochrane Library and Scopus databases up to October 2021, to identify studies answering the PECOS and PICOS questions.ResultsSeventy‐five articles were selected. Meta‐analyses identified statistically significant associations of periodontitis with COPD (nstudies = 12, odds ratio [OR] = 1.28, 95% confidence interval [CI] [1.16; 1.42], p < .001), and OSA (ns = 6, OR = 1.65, 95% CI [1.21; 2.25], p = .001), but not for asthma (ns = 9, OR = 1.53, 95% CI [0.82; 2.86], p = .181). For acute conditions, two studies were found for CAP, while for COVID‐19, significant associations were found for the need of assisted ventilation (ns = 2, OR = 6.24, 95% CI [2.78; 13.99], p < .001) and COVID‐related mortality (ns = 3, OR = 2.26, 95% CI [1.36, 3.77], p = .002). Only four intervention studies were found, showing positive effects of periodontal treatment on COPD, asthma and CAP.ConclusionsA positive association between periodontitis and COPD, OSA and COVID‐19 complications has been found, while there is a lack of intervention studies.
Atrophic papulosis (Köhlmeier–Degos disease) in children and adolescents—A cross–sectional study and literature review
Authors: Zouboulis Christos C. , Kaleta Katarzyna P. , Broniatowska Elżbieta , Jarienė Vaiva , Nikolakis Georgios 
Published: January 2023

AbstractBackgroundAtrophic papulosis (Köhlmeier–Degos disease, Degos disease) is a rare thrombo‐obliterative microangiopathy of unknown pathogenesis. It usually affects people between the ages of 20 and 50. However, it can occur at any age. The condition is considered uncommon in children.ObjectiveClinical characterization of paediatric patients with atrophic papulosis.MethodsSingle‐centre prospective cohort study with data derived from the international Degos Disease Registry collected between 2000 and 2021.ResultsAmong 96 registered patients with atrophic papulosis fulfilling the criteria, 19 were aged 0 to completed 17 years at the time of onset. The median age at the time of onset was 5 years, ranging from 0 to 1 years for girls to 8 years for boys. In contrast to adult patients (male‐to‐female ratio 1:2.2), there was a male predominance in paediatric patients with a male‐to‐female ratio of 1.7:1. Systemic involvement, in particular gastrointestinal, central nervous system and cardiac, was more frequent in children than in adult patients. There were no statistically significant differences between family history, multisystem involvement, mortality and median survival time in the two groups.ConclusionsAtrophic papulosis has some distinct features in the paediatric population. It presents an important and still under‐recognized problem. Therefore, it is mandatory to pay attention to the typical skin lesions in combination with neurological or gastrointestinal symptoms in order to make a prompt and accurate diagnosis.
Multispectral optoacoustic tomography to differentiate between lymph node metastases and coronavirus‐19 vaccine‐associated lymphadenopathy
Authors: Placke Jan‐Malte , Mertens Delphine , Tasdogan Alpaslan , Chorti Eleftheria , Schadendorf Dirk , Ugurel Selma , Roesch Alexander , Stoffels Ingo , Klode Joachim 
Published: January 2023

AbstractIntroductionWorldwide mass vaccination for COVID‐19 started in late 2020. COVID‐19 vaccines cause benign hypermetabolic lymphadenopathies. Clinical stratification between vaccine‐associated benign lymphadenopathies and malignant lymphadenopathies through ultrasound, MRI or FDG PET‐CT is not feasible. This leads to unnecessary lymph node biopsies, excisions and even radical lymph node dissections. Therefore, to avoid unnecessary surgeries, we assessed whether noninvasive multispectral optoacoustic tomography (MSOT) enables a better differentiation between benign and malignant lymphadenopathies.Patients and MethodsAll patients were vaccinated for COVID‐19. We used MSOT to image deoxy‐ and oxyhaemoglobin levels in lymph nodes of tumour patients to assess metastatic status. MSOT imaging results were compared with standard ultrasound and pathological lymph node analysis. We also evaluated the influences of gender, age and time between vaccination and MSOT measurement of lymph nodes on the measured deoxy‐ and oxyhaemoglobin levels in patients with reactive lymph node changes.ResultsMultispectral optoacoustic tomography was able to identify cancer‐free lymph nodes in vivo without a single false negative (33 total lymph nodes), with 100% sensitivity and 50% specificity. A statistically significant higher deoxyhaemoglobin content was detected in patients with tumour manifestations in the lymph node (p = 0.02). There was no statistically significant difference concerning oxyhaemoglobin (p = 0.65). Age, sex and time between vaccination and MSOT measurement had statistically non‐significant impact on deoxy‐ and oxyhaemoglobin levels in patients with reactive lymph nodes.ConclusionHere, we show that MSOT measurement is an advantageous clinical approach to differentiate between vaccine‐associated benign lymphadenopathy and malignant lymph node metastases based on the deoxygenation level in lymph nodes.
A nationwide 104 weeks real‐world study of dupilumab in adults with atopic dermatitis: Ineffectiveness in head‐and‐neck dermatitis
Authors: Vittrup Ida , Krogh Niels Steen , Larsen Henrik Hedegaard Pliess , Elberling Jesper , Skov Lone , Ibler Kristina Sophie , Jemec Gregor B. E. , Mortz Charlotte G. , Bach Rasmus Overgaard , Bindslev‐Jensen Carsten , Dalager Maiken Glud , Egeberg Alexander , Agner Tove , Deleuran Mette , Vestergaard Christian , Thyssen Jacob Pontoppidan 
Published: January 2023

AbstractBackgroundEvaluation of effectiveness and safety of new systemic treatments for atopic dermatitis (AD) after approval is important. There are few published data exceeding 52‐week therapy with dupilumab.ObjectivesTo examine the safety, effectiveness and drug survival of dupilumab in a Danish nationwide cohort with moderate‐to‐severe AD up to 104 weeks exposure.MethodsWe included 347 adult patients with AD who were treated with dupilumab and registered in the SCRATCH registry during 2017–2022.ResultsAt all visits, we observed improvement in AD severity measured by Eczema Area and Severity Index (EASI) [median (IQR)]. EASI score at baseline was 18.0 (10.6–25.2), at week 4: 6.5 (3.5–11.6), at week 16: 3.7 (1.2–6.2), at week 52: 2.0 (0.8–3.6), at week 104: 1.7 (0.8–3.8). While drug survival was high (week 52: 90%; week 104: 86%), AD in the head‐and‐neck area remained present in most patients at high levels; proportion with head‐and‐neck AD at baseline was 76% and 68% at week 104. 35% of patients reported any AE. Conjunctivitis was the most frequent (25% of all patients) and median time to first registration of conjunctivitis was 201 days.ConclusionsWhile 2‐year drug survival was 86%, dupilumab was unable to effectively treat AD in the head‐and‐neck area, and conjunctivitis was found in 25% of patients.
Characteristics of pruritus in various clinical variants of psoriasis: Final report of the binational, multicentre, cross‐sectional study
Authors: Jaworecka Kamila , Kwiatkowska Dominika , Marek‐Józefowicz Luiza , Tamer Funda , Stefaniak Aleksandra , Szczegielniak Magdalena , Chojnacka‐Purpurowicz Joanna , Gulekon Ayla , Szepietowski Jacek C. , Narbutt Joanna , Owczarczyk‐Saczonek Agnieszka , Reich Adam 
Published: January 2023

AbstractBackgroundPruritus, which is the most frequent subjective symptom of psoriasis, may cause significant discomfort, embarrassment and even interfere with patients normal daily activities. However, the perception of itch in various psoriasis subtypes remains unknown.ObjectivesThe aim of this study was to investigate and to characterize pruritus in different clinical variants of psoriasis.MethodsThis cross‐sectional, binational, multicentre study included 295 subjects suffering from nine different clinical subtypes of psoriasis: large‐plaque psoriasis (n = 45), nummular psoriasis (n = 32), guttate psoriasis (n = 31), scalp psoriasis (n = 32), inverse psoriasis (n = 23), erythrodermic psoriasis (n = 33), palmoplantar psoriasis vulgaris (n = 33), palmoplantar pustular psoriasis (n = 42) and generalized pustular psoriasis (n = 23). Measures included sociodemographic and anthropometric data, detailed pruritus characteristics including but not limited to pruritus intensity, frequency and extend, as well as psoriasis severity.ResultsThe lifetime prevalence of pruritus in each clinical variant of psoriasis was similar and quite high, reaching up to 100% in some disease subtypes (i.e., nummular psoriasis, scalp psoriasis and generalized pustular psoriasis). Psoriasis severity correlated with pruritus intensity in scalp psoriasis, palmoplantar pustular psoriasis and generalized pustular psoriasis. The age, duration of psoriasis and BMI did not interfere with the intensity of itch.ConclusionsPruritus is highly prevalent in each clinical variant of psoriasis. However, the sensation of itch is very individual, difficult to universally describe even in the same subtype.