bluuebunny/crossref_metadata_2025_split huggingface dataset:
La géographie de l’emploi industriel en Tunisie : vers un retournement des disparités régionales ?
Authors: Chagour Nejib , Haddad Samia , Bourdin Sébastien 
Published: May 2023

Cet article analyse la distribution de l’emploi du secteur industriel en Tunisie à l’échelle de délégations sur la période 2003-2018 et montre dans quelle mesure les politiques d’aménagement appliquées au lendemain de la révolution du 14 janvier 2011 ont réduit les inégalités régionales dans ce secteur. Notre étude montre l’entrée de la Tunisie dans une nouvelle étape de développement caractérisée par une spécialisation régionale vers les industries de haute technologie. Il est analysé également l’évolution de la concentration spatiale de l’emploi à partir d’une étude exploratoire des données spatiales (ESDA). Nos résultats montrent que malgré la concentration de l’emploi global, qui a baissé après la révolution, on identifie toujours un regroupement local de l’emploi dans la région du littoral. L’étude révèle aussi que la concentration de l’emploi des industries de basse technologie a reculé après la révolution et s’est propagée sur plus de délégations alors que la concentration spatiale des industries de moyenne et de haute technologie a augmenté. Classification JEL : L11, O18, R11
Importance des produits « Made in China » dans le développement économique de la Chine
Authors: Da Silva Imelda Aurore , Abodohoui Alexis , Su Zhan 
Published: May 2023

Le commerce international joue un rôle incontournable dans la croissance économique de chaque pays. En se basant sur la revue de la littérature et des statistiques descriptives, cet article traite des défis et enjeux des produits « Made in China » dans le développement économique de la Chine. Cette étude permet d’aborder l’importance des facteurs déterminants l’avenir des produits « Made in China » dans une période de turbulence économique où le commerce international pourrait être une échappatoire pour plusieurs pays qui envisageront de s’inspirer du modèle chinois. Classification JEL : F13, 025, 032, P41
L’apprentissage adulte : une agentivité limitée
Authors: Evans Karen , Carré Philippe 
Published: May 2023

L’examen des formes variées d’apprentissage et d’autoformation des jeunes et des adultes est au cœur de la problématique éducative de demain. Notre compréhension de l’adulte apprenant évolue avec la recherche sur la réflexivité, l’attitude d’apprenance, la motivation et l’agentivité. Ces thématiques sont elles-mêmes enrichies par des conceptions élargies des espaces d’apprentissage, en particulier dans les lieux de travail, les communautés et par l’expansion des technologies numériques. L’article examine ces différents aspects du débat multidisciplinaire sur l’apprentissage « tout au long de la vie » à travers une conception de l’agentivité humaine limitée, mais réelle.
Le regard d’une intruse dans l’univers colonial : Les Pieds-Noirs de Marie Cardinal
Authors: Ferraro Alessandra , Sperti Valeria 
Published: May 2023

En 1988 Marie Cardinal participe avec un long texte autobiographique agrémenté de photographies à l’album collectif Les Pieds-Noirs. Algérie 1920-1954. Ce témoignage liminaire imprime une perspective personnelle, poétique et problématique au volume. En se focalisant sur son expérience autobiographique, l’auteure, issue d’une famille matriarcale, condense l’histoire de quatre générations de femmes pieds-noires en mettant en perspective tous les stéréotypes et les rapports de force à l’œuvre dans cet échantillon colonial privé et intime. Deux perspectives s’entrecroisent dans le texte : celle des images qui ont un rôle de témoignage et celle de la narratrice qui met en question par son regard oblique, la légitimité de sa présence dans un Pays qui est pourtant le sien. La photobiographie de Marie Cardinal, loin d’être un album de famille, devient ainsi l’instrument de représentation des déchirements schizoïdes liés à la fin de l’entreprise coloniale.
Les pêcheries de Bahiret El Bibane
Authors: Faget Daniel , Khamassi Faten , Vermeren Hugo , Ben Souissi Jamila 
Published: May 2023

Exploitée pour ses ressources halieutiques depuis l’Antiquité, la lagune de Bahiret El Bibane (Tunisie) passe au début du Protectorat français sous le contrôle de concessionnaires privés, liés à l’administration coloniale. Ce changement de statut s’accompagne d’une perte de contrôle des populations locales sur la lagune. Leurs pêcheries artisanales sont démantelées, leur habitat traditionnel détruit. Une grande bordigue, qui existe encore aujourd’hui, est installée à proximité de l’îlot Sidi Ahmed Chaouch. Cette prise de possession coloniale se heurte, dès les dernières années du xixe siècle, à une résistance plus ou moins ouverte des pêcheurs locaux. Cette résistance sera régulièrement affirmée jusqu’en 1954. L’accession à l’indépendance, en maintenant l’existence de l’ancien monopole colonial, a contribué à effacer la mémoire des anciennes communautés halieutiques de la lagune. L’hostilité de certains pêcheurs au régime des concessions demeure pourtant une réalité, comme en témoigne l’ampleur des pêches illégales qui affectent aujourd’hui Bahiret El Bibane.
Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells
Authors: Jia Anna , Wang Yufei , Yang Qiuli , Wang Yuexin , Huang Yijin , Bi Yujing , Liu Guangwei 
Published: May 2023

Abstract
The mechanism of the development of granulocyte progenitor cells into neutrophils under steady-state and pathological conditions remains unclear. In this study, our results showed that with the development of neutrophils from hematopoietic stem cells to mature neutrophils, the expression level of the Hippo kinase MST1 gradually increased. Mst1-specific deficiency in myeloid cells caused neutrophilia, with an expanded granulocytic compartment resulting from a cell-autonomous increase in the number of granulocyte-macrophage progenitors under steady-state conditions and during Listeria monocytogenes infection. Mechanistically, mTOR and HIF1α signaling are required for regulating the balance between glycolysis and succinate dehydrogenase–mediated oxidative phosphorylation, which is crucial for Mst1−/−-induced proliferation of granulocyte-monocyte progenitors, lineage-decision factor C/EBPα expression, and granulopoiesis. HIF1α directly regulated C/EBPα promoter activities. Blocking mTOR and HIF1α or adjusting the balance between glycolysis and succinate dehydrogenase–mediated oxidative phosphorylation reversed the granulopoiesis induced by Mst1−/− under steady-state conditions or infection in mice. Thus, our findings identify a previously unrecognized interplay between Hippo kinase MST1 signaling and mTOR-HIF1α metabolic reprogramming in granulocyte progenitor cells that underlies granulopoiesis.
Immunomodulatory Effects of Microbiota-Derived Short-Chain Fatty Acids in Autoimmune Liver Diseases
Authors: Zhang Weici , Mackay Charles R , Gershwin M Eric 
Published: May 2023

Abstract
Nonpathogenic commensal microbiota and their metabolites and components are essential to maintain a tolerogenic environment and promote beneficial health effects. The metabolic environment critically impacts the outcome of immune responses and likely impacts autoimmune and allergic responses. Short-chain fatty acids (SCFAs) are the main metabolites produced by microbial fermentation in the gut. Given the high concentration of SCFAs in the gut and portal vein and their broad immune regulatory functions, SCFAs significantly influence immune tolerance and gut–liver immunity. Alterations of SCFA-producing bacteria and SCFAs have been identified in a multitude of inflammatory diseases. These data have particular significance in primary biliary cholangitis, primary sclerosing cholangitis, and autoimmune hepatitis because of the close proximity of the liver to the gut. In this focused review, we provide an update on the immunologic consequences of SCFA-producing microbiota and in particular on three dominant SCFAs in autoimmune liver diseases.
Clinical characterization of consecutive patients treated with endovenous radiofrequency ablation of the great saphenous vein in Northwest China
Authors: Zhao Yongfeng , Yang Qian , Zhao Xiaoyu , Dong Zilong , Chen Xi , Liu Zhen , Tang Peng , Xu Hui , Chi Yung-Wei , Liu Liwen 
Published: May 2023

INTRODUCTION:
The goal of this study was to characterize consecutive patients in Northwest China treated with endovenous radiofrequency ablation (RFA) and foam sclerotherapy over a 10-month period in 2020.

METHODS:
A total of 55 (31 men) patients were analyzed. An ultrasound examination was performed preprocedure and at set intervals up to 6 months postprocedure. The clinical-etiological-anatomical-pathophysiological classification, Venous Clinical Severity Score (VCSS), and heaviness, achiness, swelling, throbbing, and itching (HASTI) score were used.

RESULTS:
Ultrasound confirmed 23 (41.8%) patients had unilateral disease and 32 (58.2%) had bilateral disease. Of the total 87 limbs, C2 predominated (42;48.3%). At 6 months postprocedure, VCSS improved in the C2, C4, C5, and C6 classes (P < 0.001); HASTI improved in the C2, C3, C4, and C5 classes (P < 0.001).

CONCLUSION:
This is one of the few clinical characterizations of patients who had RFA and foam sclerotherapy in Northwest China. Overall, both the VCSS and the HASTI score demonstrated improvement postintervention.
Internet addiction among undergraduate medical students in Myanmar: A cross-sectional study
Authors: Soe Pa Pa , Oo Khin May , Chi Phoo Nay , Win Phyo Thet Naing , Oo Win Myint 
Published: May 2023

Objective:
To determine the prevalence of internet addiction and its associated factors among undergraduate students attending medical universities in Myanmar.

Methods:
Internet addiction was assessed using Young's internet addiction test. Multiple logistic regression analysis was applied to determine the factors associated with internet addiction. Altogether 950 students from all medical universities were included in the study voluntarily.

Result:
The prevalence of internet addiction in the study population was 72.2% (95%CI: 69.3%, 75.0%). According to the results of multiple logistic regression analysis, age, percentage of pocket money spent for internet, time spent per day using the internet, peer pressure, health-related behaviours (irregular meals, sleep disturbances, and missing social gatherings), and academic performance (postponement of the study and inability to concentrate on studying) were significant predictors of internet addiction.

Conclusions:
There is a high prevalence of internet addiction among Myanmar undergraduate medical students. Appropriate interventions, including promotion and strengthening of active and healthy lifestyles among students, should be implemented to prevent internet addiction and its adverse outcomes.
Treatment of Cutaneous Leishmaniasis With Intense Pulsed Light: Is It Effective?
Authors: Siadat Amirhossein , Galehdari Hamid , Shahmoradi Zabiholah , Iraji Fariba , Zolfaghari Azadeh , Ansari Nazli 
Published: May 2023

Background:
Cutaneous leishmaniasis (CL) is a common parasitic disorder that is endemic in many countries. There is no completely effective treatment for this condition, but pentavalent antimony compounds are regarded as the main treatment. Different laser types have been used for treatment of CL with variable success but to our best knowledge, there is no published paper regarding use of intense pulsed light (IPL) for treatment of CL.

Materials and Methods:
In this randomized, single-blind clinical trial study, we compared the efficacy of intralesional glucantime alone versus intralesional glucantime plus weekly IPL for treatment of 54 patients with confirmed cutaneous leishmaniasis for a maximum of eight weeks as a randomized, clinical trial.

Results:
Although it was not statistically significant, combination treatment was more effective than intralesional glucantime alone (P > 0.05). However, the velocity of healing was significantly higher in the IPL plus intralesional glucantime alone versus glucantime alone. No side effect was observed in both groups.

Discussion:
To better evaluate the efficacy of IPL, more studies with a higher number of patients and using various IPL filters are recommended.
Steroid in the Treatment of Outpatient COVID-19: A Multicenter Randomized Controlled Trial
Authors: Amra Babak , Vaezi Atefeh , Soltaninejad Forogh , Salahi Mehrdad , Salmasi Mehrzad , Haghjooy Javanmard Shaghayegh 
Published: May 2023

Background:
Early treatment of COVID-19 patients could reduce hospitalization and death. The effect of corticosteroids in the outpatient setting is still unknown. This study aimed to determine the effect of corticosteroids in the prevention of hospitalization of nonsevere cases.

Materials and Methods:
This study is a multicenter randomized controlled trial. Seventy five nonsevere COVID-19 patients presented between days 7 and 14 of their symptoms received either prednisolone or placebo. The primary outcome was hospitalization. The study protocol was registered in the Iranian Registry of Clinical Trials on December 2, 2020 (IRCT20171219037964N2).

Results:
Although the rate of hospitalization in the prednisolone group was higher than the placebo group (10.8% vs. 7.9%, respectively), it was not statistically significant (P value.,6). One patient in each group reported an adverse event and withdrew the medication.

Conclusion:
Considering the null effect of corticosteroids in the prevention of hospitalization in outpatient settings, it is suggested not to consider corticosteroids for outpatient treatment.
Evaluation of the Preventive Effects of Neostigmine Plus Atropine on Post-Dural Puncture Headache
Authors: Ahmadzade Zahra , Golparvar Mohammad , Sepiani Shahram 
Published: May 2023

Background:
Post-dural puncture headache (PDPH) is one of the most common side effects of spinal anesthesia. Several strategies and drugs have been suggested for the treatment and/or prevention of this headache. The aim of this study is evaluating the effects of intravenous prescription of neostigmine plus atropine 15 minutes after dural puncture on incidence and severity of PDPH during 5 days of follow-up in the setting of lower limb orthopedic surgeries.

Materials and Methods:
In a randomized, controlled, double-blind clinical trial, 99 patients of lower limb orthopedic surgeries were randomized into study (49 patients) and control groups (50 patients). Fifteen minutes after dural puncture, participants in the two groups intravenously took neostigmine (40 μg/kg) plus atropine (20 μg/kg) and placebo (normal saline), respectively. Side effects of the studied drugs and incidence, severity, and duration of PDPH were evaluated 5 days after surgery.

Results:
A total of 20 patients in the study group and 31 in the control group showed a headache-with-PDPH profile during 5 days of follow-up (P-value = 0.035). The mean duration of PDPH was 1.15 ± 0.48 and 1.32 ± 0.54 days in the study and control groups, respectively (P-value = 0.254).

Conclusion:
Preventive administration of 40 μg/kg neostigmine plus 20 μg/kg of atropine may be effective in reducing the incidence and severity of PDPH after spinal anesthesia in lower limb orthopedic surgeries.
Acoustic Trauma in Soldiers: Pure-Tone Audiometry versus Distortion Product Otoacoustic Emissions as a Tool for Early Detection
Authors: Gupta Atul , Raj Poonam , Sood Amit , Raghavan Anil 
Published: May 2023

Background:
Acoustic trauma is the sudden hearing loss that results following exposure to a single intense sound. Military environments inherently expose its personnel to very high levels of noise. Early detection of temporary or permanent hearing damage in soldiers following acoustic trauma and identification of their susceptibility to noise exposure is of utmost importance to better protect and prevent hearing deterioration. Conventionally, pure-tone audiometry (PTA) has been used as a screening method to detect hearing threshold shift following noise exposure. However, research now suggests distortion product otoacoustic emission (DPOAE) as a more sensitive tool to detect early changes in hearing thresholds following acoustic trauma. The aim of this study is to compare PTA and DPOAE for the early detection of acoustic trauma in soldiers.

Methods:
A prospective cohort multicentric study was conducted over a 2-year duration at 5 military hospitals on 1500 newly inducted recruits with no previous exposure to firing. After a thorough history taking and a comprehensive ENT examination, PTA and DPOAE tests were conducted at three intervals: before firing (initial evaluation), 2 h after firing (mid-evaluation), and 7 days after firing (final evaluation). The symptoms presented by the recruits were also analyzed. Statistical analysis between the two modalities of investigation to detect early acoustic trauma was done using Chi-square test.

Results:
Four hundred and eighty-seven recruits (36.07%) developed temporary threshold shifts and 103 (7.6%) had permanent threshold shifts. The most common symptom at mid-evaluation was tinnitus (501; 37.11%) while the least common symptom reported was isolated dizziness (10; 0.74%). At final evaluation, the most common symptom was found to be tinnitus (132; 9.77%).

Conclusion:
PTA and DPOAE can both be effectively used as a tool of measurement for the detection of early acoustic trauma, though being an objective test DPOAE has the advantage of eliminating subjective variation.
The Outcome of a Single-Stage Endoscopic Tympanoplasty with Septoplasty Using Autologous Septal Cartilage Graft in Patients with Mucosal Chronic Otitis Media and Deviated Nasal Septum
Authors: Singh Chandra Veer , Jain Shraddha 
Published: May 2023

Background:
Single-stage endoscopic tympanoplasty with septoplasty using autologous septal cartilage graft in patients with mucosal chronic otitis media and deviated nasal septum had resulted in successful repair of the tympanic membrane perforation and correction of the deviated nasal septum with improved eustachian tube dysfunction at the same time.

Aims and Objectives:
To study the structural and functional outcome of single-stage endoscopic Type 1 tympanoplasty using autologous septal cartilage graft after septoplasty in patients having mucosal chronic otitis media and deviated nasal septum.

Material and Methods:
We prospectively analysed 102 patients with chronic mucosal otitis media and central perforation of the tympanic membrane and deviated nasal septum with Eustachian tube dysfunction. The patients underwent endoscopic Type I tympanoplasty using an autologous septal cartilage graft with a thickness of approximately 0.5 mm that was harvested during endoscopic septoplasty. Morphological and functional results were recorded at 1, 6 and 12 month follow ups.

Result:
All patients were between years of age 31 to 40 years (31%). The average age of the study subject was 33.38 ± 12.63 years, with the male to female ratio of 1.31. Postoperatively the patients were looked for the acceptance of the cartilage graft and hearing gain. Of the total 102 patients, in 90 patients, eardrums perforations were closed satisfactorily, and 12 patients suffered from residual perforation (12%). On the functional front the mean pre-operative hearing loss of 40.98 ± 8.71 dB, improved significantly to 32 ± 9.06 dB postoperatively (P-value < 0.001). with a mean gain of 8.98 dB. Also, the mean pre-operative Air-Bone gap (27 ± 9.13 dB) was reduced postoperatively (13.82 ± 8.45 dB) (P-value < 0.001). Thus, improvement was noted to be 13.18 dB.

Conclusion:
Endoscopic cartilage tympanoplasty with autologous septal cartilage graft of the nose is a safe and effective way for Type I tympanoplasty with good structural and functional results and added benefits of reduced operating time, optimal graft uptake rate, minimal morbidity and pain and more importantly, ear surgery without a postauricular scar.
Double-Layer Fascial Grafts in Type I Tympanoplasty for Subtotal Perforation: A Case–Control Study
Authors: Elsheikh Ezzeddin , El-Anwar Mohammad Waheed , Nofal Ahmed Abdelfattah 
Published: May 2023

Objective:
The objective of this study was to assess the double-layer temporalis fascia grafting for myringoplasty for subtotal tympanic membrane (TM) perforation regarding graft uptake and hearing gain.

Patients and Methods:
The study included 60 patients with subtotal TM perforation attributed to tubotympanic suppurative otitis media. Myringoplasty was done through a postauricular approach using the underlay technique by two layers of the temporalis fascia grafts in the study group and one layer of the temporalis fascia graft in the control group. The procedure was considered successful if there was no residual TM perforation within the follow-up period.

Results:
Within included 60 patients, 30 patients in the study included 60 patients, 30 patients in the study group (11 males and 19 females) and 30 patients in the control group (9 males and 21 females). The success rate of TM healing was 100% in the case group and 87.7% in the control group with significant difference (P = 0.038). The hearing gains (>10 dB) were reported in 96.7% in the case group while it was 70% in the control group which is significantly better (P = 0.00558).

Conclusion:
The double-layer temporalis fascia graft is effective for both postoperative graft taking and hearing improvement for subtotal (Grade 4) TM perforation.
A Comparative Study of Endoscopic versus Microscopic Tympanoplasty in Chronic Otitis Media
Authors: Bishnoi Sandeep , Singhal Pawan , Nirwan Siddharth , Bansal Kshitiz , Gupta Nishant , Raj Mansi , Verma Samta , Jangir Jitendra Kumar , Jat Kailash Singh , Sharma Anjani Kumar 
Published: May 2023

Background:
To compare the results between tympanoplasty performed with transcanal endoscopic ear surgery and microscopic ear surgery for the treatment of chronic otitis media.

Materials and Methods:
A double-blind randomized prospective study was performed on inactive chronic otitis media patients that underwent tympanoplasty and later follow-up for at least 6 months in terms of graft uptake and hearing gain. Seventy patients were selected and randomized in Group A-endoscopic tympanoplasty and Group B-microscopic tympanoplasty.

Results:
In our study, we found that the graft take up rate was 94.3% (33/35) in Group A and 91.4% (32/35) in Group B. The improvements in the air-conduction levels and the air-bone gaps were not significantly different between the two groups (P > 0.05). The average hearing gains in the endoscopic group postsurgery were 10.51 ± 4.71 dB and in the microscopic group were 12.23 ± 4.72 dB (P = 0.132). The average operating time was 37.77 ± 5.33 min in the endoscopic group which was better than the microscopic group which was 45.77 ± 5.29 min, (P < 0.001).

Conclusion:
Endoscopic tympanoplasty technique is a feasible alternative to the conventional microscopic technique owing to the findings in terms of duration of surgery and graft uptake. In addition, the endoscopic approach provides better postoperative cosmesis, patient satisfaction, and early mobilization.
A colic mesothelial cyst, mimicking an appendicular mucocoele in an elderly patient: A case report and a literature review
Authors: Sekkat Hamza , El Hamzaoui Jihane , Armel Kouassi Serge Kouamé , Naddouri Jaouad , Jahid Ahmed , Elouarith Ihssan , El Bakali Youness , Raiss Mohammed , Sabbah Farid , Hrora Abdelmalek , El Alaoui Mouna Mhamdi 
Published: May 2023

Abstract
Benign cystic mesothelioma is a very rare and uncommon lesion, first reported by Plaut in 1928. It affects young women of reproductive age. It is usually asymptomatic or has non-specific symptoms. Diagnosis remains difficult despite the evolution of imaging, and the histopathological study is the key examination to make the diagnosis. Surgery remains the only curative treatment, regardless of significant rate of recurrence, and until today, no consensus on the therapeutic strategy is established.