bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responses to Exercise at the Critical Heart Rate vs. the Power Output Associated With the Critical Heart Rate
Authors: Succi Pasquale J. , Dinyer-McNeely Taylor K. , Voskuil Caleb C. , Abel Mark G. , Clasey Jody L. , Bergstrom Haley C. 
Published: June 2023

Abstract
Succi, PJ, Dinyer-McNeely, TK, Voskuil, CC, Abel, MG, Clasey, JL, and Bergstrom, HC. Responses to exercise at the critical heart rate vs. the power output associated with the critical heart rate. J Strength Cond Res XX(X): 000–000, 2023—This study examined the physiological (volume of oxygen consumption [V̇o
2], heart rate [HR], power output [PO], respiration rate [RR], muscle oxygen saturation [%SmO2]), neuromuscular (electromyographic and mechanomyographic amplitude [EMG AMP and MMG AMP] and mean power frequency [EMG MPF and MMG MPF]), and perceptual (rating of perceived exertion [RPE]) responses during exercise anchored at the critical heart rate (CHR) vs. the PO associated with CHR (PCHR). Nine subjects (mean ± SD; age = 26 ± 3 years) performed a graded exercise test and 4 constant PO trials to exhaustion at 85–100% of peak PO (PP) to derive CHR and PCHR on a cycle ergometer. Responses were recorded during trials at CHR (173 ± 9 b·min−1, time to exhaustion [TLim] = 45.5 ± 20.2 minutes) and PCHR (198 ± 58 W, TLim = 21.0 ± 17.8 minutes) and normalized to their respective values at PP in 10% intervals. There were significant (p ≤ 0.05) mode (CHR vs. PCHR) × time (10%–100% TLim) interactions for all variables (p < 0.001–0.036) except MMG AMP (p > 0.05). Post hoc analyses indicated differences across time for CHR V̇o
2 (%change = −22 ± 16%), PCHR V̇o
2 (19 ± 5%), CHR RR (24 ± 23%), PCHR RR (45 ± 14%), CHR PO (−33 ± 11%), PCHR HR (22 ± 5%), CHR RPE (22 ± 14%), PCHR RPE (39 ± 6%), CHR %SmO2 (41 ± 33%), PCHR %SmO2 (−18 ± 40%), CHR EMG AMP (−13 ± 15%), PCHR EMG AMP (13 ± 13%), CHR EMG MPF (9 ± 8%), CHR MMG MPF (7 ± 11%), and PCHR MMG MPF (−3 ± 14%). The critical heart rate was more sustainable than PCHR but required adjustments in PO which traversed intensity domains and caused dissociations of the responses previously observed in exercise anchored to PO. These dissociations indicated the demands to exercise varied with anchoring scheme and provides an important consideration for practitioners prescribing endurance exercise.
βII-Spectrin Is Required for Synaptic Positioning during Retinal Development
Authors: Goswami-Sewell Debalina , Bagnetto Caitlin , Gomez Cesiah C. , Anderson Joseph T. , Maheshwari Akash , Zuniga-Sanchez Elizabeth 
Published: June 2023

Neural circuit assembly is a multistep process where synaptic partners are often born at distinct developmental stages, and yet they must find each other and form precise synaptic connections with one another. This developmental process often relies on late-born neurons extending their processes to the appropriate layer to find and make synaptic connections to their early-born targets. The molecular mechanism responsible for the integration of late-born neurons into an emerging neural circuit remains unclear. Here, we uncovered a new role for the cytoskeletal protein βII-spectrin in properly positioning presynaptic and postsynaptic neurons to the developing synaptic layer. Loss of βII-spectrin disrupts retinal lamination, leads to synaptic connectivity defects, and results in impaired visual function in both male and female mice. Together, these findings highlight a new function of βII-spectrin in assembling neural circuits in the mouse outer retina.SIGNIFICANCE STATEMENTNeurons that assemble into a functional circuit are often integrated at different developmental time points. However, the molecular mechanism that guides the precise positioning of neuronal processes to the correct layer for synapse formation is relatively unknown. Here, we show a new role for the cytoskeletal scaffolding protein, βII-spectrin in the developing retina. βII-spectrin is required to position presynaptic and postsynaptic neurons to the nascent synaptic layer in the mouse outer retina. Loss of βII-spectrin disrupts positioning of neuronal processes, alters synaptic connectivity, and impairs visual function.
Lrrn1Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti
Authors: Maunsell Helen R. , Ellis Kathryn , Kelley Matthew W. , Driver Elizabeth Carroll 
Published: June 2023

One of the most striking aspects of the sensory epithelium of the mammalian cochlea, the organ of Corti (OC), is the presence of precise boundaries between sensory and nonsensory cells at its medial and lateral edges. A particular example of this precision is the single row of inner hair cells (IHCs) and associated supporting cells along the medial (neural) boundary. Despite the regularity of this boundary, the developmental processes and genetic factors that contribute to its specification are poorly understood. In this study we demonstrate thatLeucine Rich Repeat Neuronal 1(Lrrn1), which codes for a single-pass, transmembrane protein, is expressed before the development of the mouse organ of Corti in the row of cells that will form its medial border. Deletion ofLrrn1in mice of mixed sex leads to disruptions in boundary formation that manifest as ectopic inner hair cells and supporting cells. Genetic and pharmacological manipulations demonstrate thatLrrn1interacts with the Notch signaling pathway and strongly suggest that Lrrn1 normally acts to enhance Notch signaling across the medial boundary. This interaction is required to promote formation of the row of inner hair cells and suppress the conversion of adjacent nonsensory cells into hair cells and supporting cells. These results identify Lrrn1 as an important regulator of boundary formation and cellular patterning during development of the organ of Corti.SIGNIFICANCE STATEMENTPatterning of the developing mammalian cochlea into distinct sensory and nonsensory regions and the specification of multiple different cell fates within those regions are critical for proper auditory function. Here, we report that the transmembrane protein Leucine Rich Repeat Neuronal 1 (LRRN1) is expressed along the sharp medial boundary between the single row of mechanosensory inner hair cells (IHCs) and adjacent nonsensory cells. Formation of this boundary is mediated in part by Notch signaling, and loss ofLrrn1leads to disruptions in boundary formation similar to those caused by a reduction in Notch activity, suggesting that LRRN1 likely acts to enhance Notch signaling. Greater understanding of sensory/nonsensory cell fate decisions in the cochlea will help inform the development of regenerative strategies aimed at restoring auditory function.
The Emergence of Tuning to Global Shape Properties of Radial Frequency Patterns in the Ventral Visual Pathway
Authors: Lawrence Samuel J. D. , Zamboni Elisa , Vernon Richard J. W. , Gouws André D. , Wade Alex R. , Morland Antony B. 
Published: June 2023

Radial frequency (RF) patterns, created by sinusoidal modulations of a circle's radius, are processed globally when RF is low. These closed shapes therefore offer a useful way to interrogate the human visual system for global processing of curvature. RF patterns elicit greater responses than those to radial gratings in V4 and more anterior face-selective regions of the ventral visual pathway. This is largely consistent with work on nonhuman primates showing curvature processing emerges in V4, but is evident also higher up the ventral visual stream. Rather than contrasting RF patterns with other stimuli, we presented them at varied frequencies in a regimen that allowed tunings to RF to be derived from 8 human participants (3 female). We found tuning to low RF in lateral occipital areas and to some extent in V4. In a control experiment, we added a high-frequency ripple to the stimuli disrupting the local contour. Low-frequency tuning to these stimuli remained in the ventral visual stream, underscoring its role in global processing of shape curvature. We then used representational similarity analysis to show that, in lateral occipital areas, the neural representation was related to stimulus similarity, when it was computed with a model that captured how stimuli are perceived. We therefore show that global processing of shape curvature emerges in the ventral visual stream as early as V4, but is found more strongly in lateral occipital regions, which exhibit responses and representations that relate well to perception.SIGNIFICANCE STATEMENTWe show that tuning to low radial frequencies, known to engage global shape processing mechanisms, was localized to lateral occipital regions. When low-level stimulus properties were accounted for such tuning emerged in V4 and LO2 in addition to the object-selective region LO. We also documented representations of global shape properties in lateral occipital regions, and these representations were predicted well by a proxy of the perceptual difference between the stimuli.
Targeting shared molecular etiologies to accelerate drug development for rare diseases
Authors: Zanello Galliano , Garrido‐Estepa Macarena , Crespo Ana , O'Connor Daniel , Nabbout Rima , Waters Christina , Hall Anthony , Taglialatela Maurizio , Chan Chun‐Hung , Pearce David A , Dooms Marc , Brooks Philip John 
Published: June 2023

AbstractRare diseases affect over 400 million people worldwide and less than 5% of rare diseases have an approved treatment. Fortunately, the number of underlying disease etiologies is far less than the number of diseases, because many rare diseases share a common molecular etiology. Moreover, many of these shared molecular etiologies are therapeutically actionable. Grouping rare disease patients for clinical trials based on the underlying molecular etiology, rather than the traditional, symptom‐based definition of disease, has the potential to greatly increase the number of patients gaining access to clinical trials. Basket clinical trials based on a shared molecular drug target have become common in the field of oncology and have been accepted by regulatory agencies as a basis for drug approvals. Implementation of basket clinical trials in the field of rare diseases is seen by multiple stakeholders—patients, researchers, clinicians, industry, regulators, and funders—as a solution to accelerate the identification of new therapies and address patient's unmet needs.
Importancia de la Digitalización Docente para una Educación Inclusiva, Crítica y Equitativa
Authors: López Bueno Helena , Val Sonia , Gaeta González Martha Leticia 
Published: June 2023

En la sociedad actual, las competencias digitales del profesorado desempeñan un papel fundamental para guiar a los alumnos en la adquisición de habilidades y destrezas, no sólo en el terreno de las nuevas tecnologías, sino como medio para compensar desigualdades y tender hacia una educación más equitativa. La formación del profesorado y el desarrollo profesional específico y continuo son esenciales para mejorar la enseñanza y el aprendizaje de las nuevas generaciones, preparándolas para los nuevos escenarios sociales y laborales. Cada vez es mayor la necesidad y el interés por dotar al profesorado de estas competencias, creando marcos y herramientas de diagnóstico que ayuden al docente a autoevaluarse para recibir programas de formación y orientación acordes a sus necesidades.
El objetivo de este trabajo de investigación es conocer, a través de un cuestionario específico basado en la herramienta SELFIE, las competencias digitales de los futuros profesores, y cómo las ponen al servicio de una educación más inclusiva en sus aulas.
Los resultados muestran que las competencias digitales de los futuros profesores no se abordan de forma específica, como tampoco se reflexiona sobre las necesidades y los usos sociales que se hace de la digitalización de la educación. Los estudiantes del máster son conscientes de la importancia de tener los conocimientos necesarios para utilizar estas tecnologías de forma consciente, crítica y democrática en su futura docencia, pero no encuentran la formación adecuada que exige el nuevo paradigma educativo.
Spontaneous magnetization of a vacuum in high temperature gluodynamics (two-­loop approximation)
Authors: Skalozub V. 
Published: June 2023

In SU(N) gluodynamics, at high temperature the spontaneous magnetization, b(T) ≠ 0, of a vac­uum happens in the approximation to the effective potential ­- the tree plus the one-­loop, plus daisy diagrams, W(b) = b2/2g2 + W(1)(b) + Wdaisy(b). At the same time, in two­-loop approximation, W(A0) = W(1) (A0) + W(2)(A0), other classical field ­ A0 condensate directly related to the Polyakov loop - ­is also spontaneously generated. To investigate the creation of the condensates together, the two-loop effective po­tential of both fields should be calculated. This program was realized recently for SU(2) in [1]. However, the generation of magnetic field in two­-loop order was not studied in detail. In the present paper, we compute the value of chromomagnetic field b(T) for latter case. Then, considering the spectrum of color charged gluons at the background of both condensates, we conclude that the A0 stabilizes the magnetized vacuum at high temperature. This is in agreement with the lattice simulations carried out already and clarifies the mechanism of the magnetic field stabilization.
DIFFICULTY OF DIAGNOSING METASTATIC BREAST CANCER IN A PATIENT AFTER MINIMALLY INVASIVE AORTIC VALVE REPLACEMENT: A CLINICAL CASE
Authors: Evtushenko Vladimir V. , Zhilina Alexandra N. , Saushkin Viktor V. , Evtushenko Alexey V. 
Published: June 2023

HighlightsThe article describes a clinical case of a patient with metastatic breast cancer detected after aortic valve replacement. The case was initially treated as sternal osteomyelitis due to ministernotomy performed during aortic valve surgery. However, the diagnosis of metastatic breast cancer with sternal and spinal (third thoracic vertebra) metastatses, and ribs lesion was established upon further study. Adjuvant endocrine therapy was prescribed to the patient due to her age and previous surgery. AbstractBreast cancer is an urgent problem in oncology as it remains the most frequent type of cancer in the Russian Federation and world wide. Long-term treatment success and survival of patients depend on selected treatment modality, and long-term postopertive monitoring of patients as the means of the early detection of metastatic recurrence. Furthermore, concominant somatic ilness could change or mask the symptoms of local recurrence or metastasis, resulting in difficulties with establishing the proper diagnosis. We report a clinical case of metastatic breast cancer in a patient with severe aortic stenosis who underwent aortic valve replacement. We have not found analogious cases in domestic and foreign literature.
LINGUISTIC AND COGNITIVE DISORDERS IN 4-6 YEARS OLD PATIENTS WITH CONGENITAL HEART DEFECTS BEFORE AND AFTER SURGICAL CORRECTION
Authors: Rumiantseva Aleksandra A. , Igisheva Lyudmila N. , Kameneva Veronika A. 
Published: June 2023

Highlights There are data about speech disorders in children with congenital heart defects. The results of the speech research in 4–6 years old children before and after surgery are described according to the surgical tactics. Aim. To compare linguistic and cognitive disorders in in 4–6 years old children with congenital heart defects before and after surgery.Methods. A prospective investigation of group of children (n = 92) with septal heart defects was done before and after surgery and within decreed terms: in 1 and 2 years after the surgical correction of congenital heart defects in cardiopulmonary bypass or in cath-lab in Research Institute for Complex Issues of Cardiovascular Diseases. The anamnesis, clinical and hemodynamic aspects were studied before and after surgery, as well as early postoperative period, residual hemodynamic disorders and speech diagnostic was also done.Results. 57% children had different speech disorders (general or delayed speech development) in preoperative period. It was made worse by cardiosurgery: the number of children with speech disorders increased to 63% in a year after surgery and was 59.8% in 2 years, while there was a positive dynamic in clinical and hemodynamic aspects. Conclusion. There are speech disorders in children with septal heart defects after surgery in long-term postoperative period despite of clinical and hemodynamic normalization. That can lead to the real risks and quality of life worsening in general in the absence of timely correction.
Clinical case of a 29 weeks pregnant patient with ST-segment elevation myocardial infarction
Authors: Serdechnaya Anastasia Y. , Sukmanova Irina A. 
Published: June 2023

HighlightsThis clinical case describes the management of a 29 weeks pregnant patient with myocardial infarction. The material will be useful for cardiologists, physicians, obstetricians and gynecologists, and endovascular surgeons. AbstractUnavoidable drastic changes in lifestyle due childbirth are pushing women to postpone it to an older age, thus increasing the risk of coronary artery disease (CAD) in pregnant women. This can be a problem not only for patients, but also for specialists. Currently there are 3-6 cases of acute coronary syndrome (ACS) per 100 thousand pregnancies, meaning such cases occur rarely in real clinical practice. Discomfort in the chest area does not directly indicate cardiac problem, so women do not visit cardiologist right away, and thus ACS remains undiagnosed. Besides traditional risk factors for CAD (age, dyslipidemia, smoking, physical inactivity), there are some additional obstetric factors: preeclampsia, thrombophilia and postpartum bleeding. About 40% of patients have myocardial infarction in the third trimester. Atherosclerosis is the most common cause of ACS, with coronary artery spasms, coronary artery dissection and thrombosis following behind. Currently the maternal mortality due to MI has decreased from 20% to 5% due to introduction of the percutaneous coronary intervention (PCI) into the treatment of ACS. There are not enough data on the use of thrombolytics and other medicine in the treatment of CAD, because pharmacological therapy can be dangerous in the early pregnancy at the peak of organogenesis. Moreover, PCI should be used with caution due to harmful effects of radiation on the pregnant woman and the fetus. The main task in later stages of pregnancy is to balance out the risk of stent thrombosis upon discontinuing double antiplatelet therapy and bleeding during childbirth and in the postpartum period. This article describes a clinical case of a 29 weeks pregnant patient with myocardial infarction.
ANATOMICAL FEATURES OF THE CARDIAC VENOUS SYSTEM, SIGNIFICANT FOR THE LEFT VENTRICULAR LEAD PLACEMENT: LITERATURE REVIEW AND EXPERIENCE
Authors: Dubrovin Oleg L. , Mamchur Sergey E. , Shugaev Pavel L. 
Published: June 2023

HighlightsThe article is a comprehensive literature review on anatomical variations and anomalies of cardiac veins. A classification of coronary venous anatomy and anomalies detailing clinical, anatomical and radiological features is proposed. Developing such classification is important for the field of left ventricular lead placement, as it would cover a variety of clinically significant anomalies of cardiac veins. AbstractWith the advancements in the cardiac resynchronization therapy, the role of cardiac vein anatomy has become vital due to the complications associated with poor left ventricle lead placement. The cardiac vein anatomy varies much more than the anatomy of the coronary arteries, thus making cardiac veins much harder to study. In this article we have analyzed different approaches to description and naming of cardiac veins, and have summarized venous anomalies and features described in literature or encountered in real clinical practice. All anatomical features described in the article have a clinical significance in the left ventricle lead placement. Moreover, we have analyzed the wide variety of suggestions to overcoming anatomical obstacles. As a result of the analysis, we have proposed a clinical classification of the coronary venous anomalies and features that can be used during the implantation of cardiac resynchronization therapy devices.
Potency Of Andrographolide, L-Mimosine And Asiaticoside Compound As Antiviral For Covid-19 Based On In Silico Method
Authors: Ningrum Dhecella , Aini Dita , Juniananda Melisa , Febriansah Rifki 
Published: June 2023

Introduction - COVID-19 is an infectious disease that is a global challenge, making it necessary for innovation and the development of antiviral agents in prevention and treatment efforts. Indonesia is known as a country rich in potential plants as medicine, a potential antiviral plant among them Andrographis paniculata , Mimosa pudica and Centella asiatica. The compound that have antiviral activity in each of these plants are andrographolide (Andrographis paniculata), L-mimosine (Mimosa pudica) and asiaticoside (Centella asiatica). The purpose of this study is to identify the potential of the andrographolide, l-mimosine and asiaticoside to inhibit SARS COV-2 protein and to predict the molecular drug profile which refers to lipinski's rule of 5.
Purpose - The purpose of this study was to determine the potential of Andrographis paniculata , Mimosa pudica and Centella asiatica compounds in inhibiting the SARS CoV-2 protein and to determine the prediction of drug profiles such as molecules referring to Lipinski's rule of 5.
Methodology - The methods used in this research by molecular docking and lipinski's Ro5 using PKCSM. The control compounds used are favipiravir and remdesivir.
Results - The results of the affinity of target protein bonds using molecular docking obtained the best results in NSP3 proteins with An Asiaticoside docking score of -10.1 kcal / mol stronger than favipiravir -5.3 kcal/mol and remdesivir -8.6 kcal/mol. As for the compounds L-mimosine -6.1 kcal / mol and Andrographolide -7.7 kcal / mol. The compounds of andrographolide and L-mimosine showed good results and met the 5 aspects of Lipinski's Ro5, but asiaticoside compounds did not good enough. .
Conclusion - The Research has concluded that the compound of the Andrographis paniculata , Mimosa pudica and Centella asiatica have a good potential in inhibiting SARS cov2 protein that is stronger than favipiravir and almost the same with remdesivir activity.