bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort
Authors: Fernández-Iglesias Rocío , Martinez-Camblor Pablo , Fernández-Somoano Ana , Rodríguez-Dehli Cristina , Venta-Obaya Rafael , Karagas Margaret R. , Tardón Adonina , Riaño-Galán Isolina 
Published: June 2023

AbstractIdentifying cardiovascular-related measures that track from early childhood into later ages may help inform early prevention targets for cardiovascular disease. In this study, the tracking of triglycerides (TG), high-density cholesterol (HDL-c), atherogenic coefficient (AC), waist circumference to height ratio (WC/Height), mean arterial pressure (MAP), and homeostatic model assessment of insulin resistance (HOMA-IR) was examined in the INMA-Asturias cohort between 4 and 8 years of age. The analysis was conducted in 307 children who participated in the INMA-Asturias cohort (Spain) at 4 and at 8 years of age. Quantile regression models were used to evaluate tracking between measures at both ages, with each measure at 8 years as the dependent variable and the rank transformation of the same measure at 4 years as the independent variable. We found a positive association between HDL-c rank at 4 years and higher quantiles of the HDL-c distribution at 8 years, with an increase of 2.93 mg/dL (95% CI: 1.98, 3.87) per decile in the 0.9 quantile. A positive association was also found for WC/Height, with an increase of 0.008 (95% CI: 0.004, 0.012) per decile in the 0.9 quantile. We observed that tracking for AC increased in the higher quantiles of the distribution at 8 years, with an increase of 0.11 (95% CI: 0.09, 0.14) in the 0.6 quantile compared to an effect of 0.15 (95% CI: 0.09, 0.21) in the 0.9 quantile. Conclusions: Adult markers of dyslipidemia and central obesity tracked between ages 4 and 8 years. For AC, tracking increased in the higher quantiles of the distribution.

What is Known:• Atherosclerosis begins in early life, so preventive efforts that start in childhood may delay progression to clinical disease. Determine what cardiovascular risk factors track into time since childhood bring the opportunity to identified those subjects at risk for later cardiovascular disease.• The study of risk factors in health populations and, particularly in children, copes with not clear and/or controversial thresholds definition. This makes it challenging to study tracking in pediatric ages.

What is New:• Quantile regression is a useful tool for assessing the tracking of risk factors for which there are no clinically meaningful thresholds. The increasing trend observed in the tracking of dyslipidemia suggests the possible difficulty that children with abnormal values at 4 years of age might have in normalizing them in future years.• The findings of this article may help to determine which cardiovascular-related measures could be screened and followed-up in children.
Psychosocial effects of the corona pandemic on people with cancer: a qualitative study
Authors: Hoppe Catalina , Büntzel Jens , Paradies Kerstin , Rösler Marie , Hübner Jutta ,   Working Group Prevention and Integrative Oncology of the German Cancer Society
Published: June 2023

Abstract
Introduction
The Corona pandemic caused far-reaching changes since 2020. We wanted to find out which factors determined the psycho-social well-being of cancer patients during the pandemic.

Methods
From May to July 2021, structured interviews were conducted concerning lockdown, social limitations, the virus itself, the treatment situation, and opportunities.

Results
Twenty people took part in the study (doctors, psychologists, nurses, social workers, patients). One of the most important aspects was the ban on visits. Others were the fear of infection and the possibility of vaccination. Wearing a mask seem to have been worse for the experts. Conflicts in families about the “right” behavior to protect yourself from infection have been a stressful issue for patients, just as the lack of balance and recreation in free time.

Conclusion
Patients in the third wave of corona have become accustomed to the rules. Especially loneliness and the organization of time at home are psycho-social stress factors.
Integrated analysis of the roles of oxidative stress related genes and prognostic value in clear cell renal cell carcinoma
Authors: Wang Danwen , Deng Zhao , Lu Mengxin , Deng Kai , Li Zhiqiang , Zhou Fenfang 
Published: June 2023

Abstract
Background
Patients with clear cell renal cell carcinoma (ccRCC), which is the most commonly diagnosed subtype of renal cell carcinoma, are at risk of tumor metastasis and recrudescence. Previous research has shown that oxidative stress can induce tumorigenesis in many cancers and can be a target of cancer treatment. Despite these findings, little progress has been made understanding in the association of oxidative stress-related genes (OSRGs) with ccRCC.

Methods
In vitro experiments were conducted with MTT survival assays, qRT‒PCR, apoptosis assays, cell cycle assays, ROS assays, and IHC staining.

Results
In our study, 12 differentially expressed oxidative stress-related genes (DEOSGs) and related transcription factors (TFs) that are relevant to overall survival (OS) were screened, and their mutual regulatory networks were constructed with data from the TCGA database. Moreover, we constructed a risk model of these OSRGs and performed clinical prognostic analysis and validation. Next, we performed protein–protein interaction (PPI) network analysis and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of MELK, PYCR1, and PML. A tissue microarray also verified the high expression of MELK and PYCR1 in ccRCC. Finally, in vitro cellular experiments demonstrated that knockdown of MELK or PYCR1 significantly inhibited ccRCC cell proliferation by causing cell apoptosis and inducing cell cycle arrest in the G1 phase. Intracellular ROS levels were elevated after these two genes were knocked down.

Conclusion
Our results revealed the potential DEORGs to be used in ccRCC prognostic prediction and identified two biomarkers, named PYCR1 and MELK, which regulated the proliferation of ccRCC cells by affecting ROS levels. Furthermore, PYCR1 and MELK could be promising targets for predicting the progression and prognosis of ccRCC, thereby serving as new targets for medical treatments.
How ecological and evolutionary theory expanded the ‘ideal weed’ concept
Authors: Lau Jennifer A. , Funk Jennifer L. 
Published: June 2023

AbstractSince Baker’s attempt to characterize the ‘ideal weed’ over 50 years ago, ecologists have sought to identify features of species that predict invasiveness. Several of Baker’s ‘ideal weed’ traits are well studied, and we now understand that many traits can facilitate different components of the invasion process, such as dispersal traits promoting transport or selfing enabling establishment. However, the effects of traits on invasion are context dependent. The traits promoting invasion in one community or at one invasion stage may inhibit invasion of other communities or success at other invasion stages, and the benefits of any given trait may depend on the other traits possessed by the species. Furthermore, variation in traits among populations or species is the result of evolution. Accordingly, evolution both prior to and after invasion may determine invasion outcomes. Here, we review how our understanding of the ecology and evolution of traits in invasive plants has developed since Baker’s original efforts, resulting from empirical studies and the emergence of new frameworks and ideas such as community assembly theory, functional ecology, and rapid adaptation. Looking forward, we consider how trait-based approaches might inform our understanding of less-explored aspects of invasion biology ranging from invasive species responses to climate change to coevolution of invaded communities.
Bedeutung großskaliger Rückbaumaßnahmen für die Minimierung der Sohleintiefung und des erforderlichen Geschiebeeintrags sowie zur Verbesserung der Morphodynamik und Ökologie an der Grenzmur
Authors: Klösch Mario , Tritthart Michael , Beikircher Ulrich , Dunst Roman , Eder Markus , Senfter Stephan , Habersack Helmut 
Published: June 2023

ZusammenfassungDie Einengung und Begradigung des Flusslaufs der Mur entlang der Staatsgrenze zwischen Österreich und Slowenien (Grenzmur) erhöhten den Geschiebetransport, während Unterbrechungen des Sedimentkontinuums im Einzugsgebiet die Geschiebenachfuhr verringerten. Diese Rahmenbedingungen führten zu gravierenden morphologischen Veränderungen und damit einhergehenden ökologischen Beeinträchtigungen und technischen Problemen. Durch die Sohleintiefung droht zudem ein gänzlicher Verlust des geringmächtigen Kiesbetts und ein Sohldurchschlag in Sedimente des Tertiärs. Gleichzeitig ist die Grenzmur in einen großen zusammenhängenden Auwald eingebettet und flussabwärts ohne Kontinuumsunterbrechung mit der Drau und der Donau verbunden, sodass dieser Abschnitt über ein großes ökologisches Potenzial verfügt. Jedoch zeigten bisherige Maßnahmen nicht die erhoffte, längerfristige sohlstabilisierende Wirkung.Im Rahmen des EU-Interreg-SI-AT-Projekts goMURra wurde ein neuer Managementplan erstellt. Als Ziele wurden ein dynamisches Gleichgewicht des Sedimenthaushalts, eine verbesserte Grundwassersituation, ein reduziertes Hochwasserrisiko und eine ökologische Verbesserung der Fluss- und Auenlandschaft definiert. Ziel der vorliegenden Studie war die Entwicklung entsprechender Maßnahmen.Zunächst wurde anhand vereinfachender Werkzeuge und anhand historischer Karten der Raumbedarf für eine natürlichere Morphologie der Grenzmur abgeschätzt. Danach wurden unter Berücksichtigung der Raumwiderstände drei Maßnahmentypen entwickelt. Zugrunde lag eine Hypothese, wonach der Geschiebebedarf zur Stabilisierung der Sohllage mit Zunahme der Breite und Sinuosität abnimmt. Numerische Simulationen der Hydrodynamik und des Sedimenttransports sowie Modellversuche dienten der eingehenden Prüfung der Maßnahmentypen.Die Modellläufe bestätigten die Verringerung der Geschiebetransportkapazität in den entwickelten Maßnahmentypen mit einer Reduktion von bis zu 56 %. Durch die Bereitstellung von mehr Platz für die Grenzmur würden die Kosten für eine dringend benötigte Geschiebezugabe gesenkt, während der ökologische Wert – am deutlichsten beim größten Maßnahmentyp – steigen würde.
On the Bahri–Lions conjecture for elliptic equations with non-symmetric nonlinearities
Authors: Molle Riccardo , Passaseo Donato 
Published: June 2023

AbstractWe prove the existence of infinitely many solutions for a class of elliptic Dirichlet problems with non-symmetric nonlinearities. In particular, in suitable domains of $${\mathbb {R}}^n$$

R

n

with $$n\ge 3$$

n
≥
3

, this result gives a positive answer to a well known conjecture formulated by A. Bahri and P.L. Lions. The proof is based on a minimization method which does not require the use of techniques of deformation from the symmetry. This method allows us to piece together solutions of Dirichlet problems in suitable subdomains, so we obtain infinitely many nodal solutions with a prescribed nodal structure.
Coexisiting type 1 diabetes and celiac disease is associated with lower Hba1c when compared to type 1 diabetes alone: data from the Australasian Diabetes Data Network (ADDN) registry
Authors: James Steven , Perry Lin , Lowe Julia , Donaghue Kim C. , Pham-Short Anna , Craig Maria E. ,   the ADDN Study Group, Ambler Geoff , Anderson Kym , Andrikopoulos Sof , Batch Jenny , Brown Justin , Cameron Fergus , Colman Peter G. , Conwell Louise , Cotterill Andrew , Couper Jennifer , Davis Elizabeth , de Bock Martin , Fairchild Jan , Fegan Gerry , Fourlanos Spiros , Glastras Sarah , Goss Peter , Gray Leonie , Hamblin Peter Shane , Hofman Paul , Holmes-Walker Dianne Jane , Huynh Tony , Isaacs Sonia , Jefferies Craig , Johnson Stephanie , Jones Tim , Kao Jeff , King Bruce R. , Lafferty Antony , Martin Michelle , McCrossin Robert , Neville Kris , Pascoe Mark , Paul Ryan , Peña Alexia , Phillips Liza , Price Darrell , Rodda Christine , Simmons David , Sinnott Richard , Smart Carmel , Stone Monique , Stranks Steve , Tham Elaine , Waddell Barbara , Ward Glenn , Wheeler Ben , Woodhead Helen , Zimmermann Anthony 
Published: June 2023

Abstract
Aim
To compare HbA1c and clinical outcomes in adolescents and young adults with type 1 diabetes (T1D), with or without celiac disease (CD).

Methods
Longitudinal data were extracted from ADDN, a prospective clinical diabetes registry. Inclusion criteria were T1D (with or without CD), ≥ 1 HbA1c measurement, age 16–25 years and diabetes duration ≥ 1 year at last measurement. Multivariable Generalised Estimated Equation models were used for longitudinal analysis of variables associated with HbA1c.

Results
Across all measurements, those with coexisting T1D and CD had lower HbA1c when compared to those with T1D alone (8.5 ± 1.5% (69.4 ± 16.8 mmol/mol) vs. 8.7 ± 1.8% (71.4 ± 19.8 mmol/mol); p < 0.001); lower HbA1c was associated with shorter diabetes duration (B = − 0.06; 95% CI − 0.07 to − 0.05; p < 0.001), male sex (B = − 0.24; − 0.36 to − 0.11; p < 0.001), insulin pump therapy use (B = − 0.46; − 0.58 to − 0.34; p < 0.001), coexistence of T1D and CD (B = − 0.28; − 0.48 to − 0.07; p = 0.01), blood pressure (B = − 0.16; − 0.23 to − 0.09; p < 0.001) and body mass index (B = -− 0.03; − 0.02 to − 0.04; p = 0.01) in the normal range. At last measurement, 11.7% of the total population had a HbA1c < 7.0% (53.0 mmol/mol).

Conclusions
Across all measurements, coexisting T1D and CD is associated with lower HbA1c when compared to T1D alone. However, HbA1c is above target in both groups.
Efficacy and effectiveness of Herpes zoster vaccination in adults with diabetes mellitus: a systematic review and meta-analysis of clinical trials and observational studies
Authors: Silverii Giovanni Antonio , Clerico Alessandra , Fornengo Riccardo , Gabutti Giovanni , Sordi Valeria , Peruzzi Ottavia , Tafuri Silvio , Mannucci Edoardo , Dicembrini Ilaria 
Published: June 2023

Abstract
Aim
The risk for Herpes zoster (HZ) and its complications is higher in people with diabetes mellitus (DM). Our aim is to assess efficacy and effectiveness of the currently available live-attenuated zoster vaccine (LZV) and recombinant zoster vaccine (RZV) in adults with DM.

Methods
A Systematic Review and Meta-analysis of clinical trials and observational studies comparing incidence of HZ and its complications in vaccinated and unvaccinated people with DM was performed, on PubMed, Cochrane, Clinical Trials.gov and Embase databases, up to January 15th, 2023. Risk of bias was assessed through the Cochrane Collaboration tool and the Newcastle–Ottawa Scale. The protocol was registered on the PROSPERO website (CRD42022370705).

Results
Only three observational studies reported LZV efficacy and effectiveness in people with DM. A lower risk for HZ infection (MH-OH Ratio 95% CI = 0.52 [0.49, 0.56] was observed, for unadjusted analysis, and 0.51 [0.46, 0.56] for adjusted analysis, both with P < 0.00001 and no heterogeneity). No data on LZV safety were reported. A pooled analysis of two trials comparing RZV and placebo, showed a reduced risk for HZ incidence: (95% CI Odds Ratio: 0.09 [0.04–0.19]), with no difference in severe adverse events and mortality.

Conclusions
In our meta-analysis of three observational studies LZV showed a 48% effectiveness in reducing HZ incidence in adults with diabetes whereas in a pooled analysis of two RCTs, RZV showed a 91% efficacy. No data are available on the effects of vaccination on the incidence and severity of HZ-related complications among subjects with diabetes.
Potential role of human umbilical cord stem cells-derived exosomes as novel molecular inhibitors of hepatocellular carcinoma growth
Authors: ElBadre Hala M , El-Deek Sahar E M , Ramadan Haidi Karam-Allah , Elbadr Mohamed M , Sabry Dina , Ahmed Noran M , Ahmed Amr M , El-Mahdy Reham I 
Published: June 2023

AbstractHepatocellular carcinoma (HCC) is one of the most critical cancers; thus, novel therapeutical regimens are of great need. In this study, we investigated the effects of umbilical cord mesenchymal stem cells (UC-MSCs) derived exosomes on HepG2 cell line, and the underlying mechanism to control HCC proliferation, to identify the potential clinical role of exosomes as a novel molecular therapeutic target. Proliferation, apoptosis, and angiogenesis effects were assessed together with the cell viability evaluation by MTT assay in HepG2 cells at 24/48 h. with or without UC-MSCs-derived exosomes. Gene expressions of TNF-α, caspase-3, VEGF, stromal cell-derived factor-1 (SDF-1), and CX chemokine receptor-4 (CXCR-4) were measured by quantitative real-time PCR technique. Expression of sirtuin-1 (SIRT-1) protein was detected by western blot. Treatment of HepG2 cells with UC-MSCs-derived exosomes for 24 and 48 h. demonstrated a significant reduction of cells survival compared to the control group (p < 0.05). The SIRT-1 protein, and VEGF, SDF-1, CXCR-4 expression levels were significantly lower, TNF-α and caspase-3 expression levels were significantly higher in exosomal-treated HepG2 cells for 24 and 48 h. than those in the control group. Moreover, our findings documented that the anti-proliferative, apoptotic, and anti-angiogenic effects were achieved in a time-dependent manner in which more effects were determined after 48 h supplementation compared to 24 h (p < 0.05). UC-MSCs-derived exosomes exert anticarcinogenic molecular effects on HepG2 cells through the involvement of SIRT-1, SDF-1, and CXCR-4. Hence, exosomes would be a potential novel therapy regimen against HCC. Large-scale studies are recommended to verify this conclusion.
Establishing effective conservation management strategies for a poorly known endangered species: a case study using Australia’s Night Parrot (Pezoporus occidentalis)
Authors: Leseberg Nicholas P. , Kutt Alex , Evans Megan C. , Nou Tida , Spillias Scott , Stone Zoe , Walsh Jessica C. , Murphy Stephen A. , Bamford Mike , Burbidge Allan H. , Crossing Kate , Davis Robert A. , Garnett Stephen T. , Kavanagh Rodney P. , Murphy Robert , Read John , Reid Julian , van Leeuwen Stephen , Watson Alexander W. T. , Watson James E. M. , Maron Martine 
Published: June 2023

AbstractAn evidence-based approach to the conservation management of a species requires knowledge of that species’ status, distribution, ecology, and threats. Coupled with budgets for specific conservation strategies, this knowledge allows prioritisation of funding toward activities that maximise benefit for the species. However, many threatened species are poorly known, and determining which conservation strategies will achieve this is difficult. Such cases require approaches that allow decision-making under uncertainty. Here we used structured expert elicitation to estimate the likely benefit of potential management strategies for the Critically Endangered and, until recently, poorly known Night Parrot (Pezoporus occidentalis). Experts considered cat management the single most effective management strategy for the Night Parrot. However, a combination of protecting and actively managing existing intact Night Parrot habitat through management of grazing, controlling feral cats, and managing fire specifically to maintain Night Parrot habitat was thought to result in the greatest conservation gains. The most cost-effective strategies were thought to be fire management to maintain Night Parrot habitat, and intensive cat management using control methods that exploit local knowledge of cat movements and ecology. Protecting and restoring potentially suitable, but degraded, Night Parrot habitat was considered the least effective and least cost-effective strategy. These expert judgements provide an informed starting point for land managers implementing on-ground programs targeting the Night Parrot, and those developing policy aimed at the species’ longer-term conservation. As a set of hypotheses, they should be implemented, assessed, and improved within an adaptive management framework that also considers the likely co-benefits of these strategies for other species and ecosystems. The broader methodology is applicable to conservation planning for the management and conservation of other poorly known threatened species.
Long-term outcomes of high-risk HR-positive and HER2-negative early breast cancer patients from GEICAM adjuvant studies and El Álamo IV registry
Authors: Martín Miguel , Carrasco Eva , Rodríguez-Lescure Álvaro , Andrés Raquel , Servitja Sonia , Antón Antonio , Ruiz-Borrego Manuel , Bermejo Begoña , Guerrero Ángel , Ramos Manuel , Santaballa Ana , Muñoz Montserrat , Cruz Josefina , Lopez-Tarruella Sara , Chacón Jose I. , Álvarez Isabel , Martínez Purificación , Miralles Juan J. , Polonio Óscar , Jara Carlos , Aguiar-Bujanda David 
Published: June 2023

Abstract
Purpose
The monarchE trial showed that the addition of abemaciclib improves efficacy in patients with high-risk early breast cancer (EBC). We analyzed the long-term outcomes of a population similar to the monarchE trial to put into context the potential benefit of abemaciclib.

Methods
HR-positive/HER2-negative EBC patients eligible for the monarchE study were selected from 3 adjuvant clinical trials and a breast cancer registry. Patients with ≥ 4 positive axillary lymph nodes (N +) or 1–3 N + with tumor size ≥ 5 cm and/or histologic grade 3 and/or Ki67 ≥ 20%, who had undergone surgery with curative intent and had received anthracyclines ± taxanes and endocrine therapy in the neoadjuvant and /or adjuvant setting were included. We performed analysis of Invasive Disease-Free Survival (iDFS), Distant Disease-Free Survival (dDFS) and Overall Survival (OS) at 5 and 10 years, as well as yearly (up to 10) of Invasive Relapse Rate (IRR), Distant Relapse Rate (DRR) and Death Rate (DR).

Results
A total of 1,617 patients were analyzed from the GEICAM-9906 (312), GEICAM-2003–10 (210), and GEICAM-2006–10 (160) trials plus 935 from El Álamo IV. With a median follow-up of 10.1 years, the 5 and 10 years iDFS rates were 75.2% and 57.0%, respectively. The dDFS and OS rates at 5 years were 77.4% and 88.8% and the respective figures at 10 years were 59.7% and 70.9%.

Conclusions
This data points out the need for new therapies for those patients. A longer follow-up of the monarchE study to see the real final benefit with abemaciclib is warranted.

Trial registration
ClinTrials.gov: GEICAM/9906: NCT00129922; GEICAM/ 2003-10: NCT00129935 and GEICAM/ 2006-10: NCT00543127.
Physicalism, Foundationalism, and Infinite Descent
Authors: Werner Jonas 
Published: June 2023

Abstract
This paper contributes to answering the question how physicalism can be defined for a world without fundamental physical phenomena. In a recent paper in this journal, Torin Alter, Sam Coleman, and Robert J. Howell propose a necessary condition on physicalism. They argue that physicalism is true only if there is no infinitely descending chain of mentally constituted phenomena. I argue that this alleged necessary condition faces counterexamples. An infinitely descending chain of mentally constituted phenomena is compatible with physicalism. Afterwards I propose a simpler definition of physicalism that does not fall prey to my counterexample.