bluuebunny/crossref_metadata_2025_split huggingface dataset:
New entrants, incumbents, and the search for knowledge: the role of job title ambiguity in the US information and communication technology industry, 2004–2014
Authors: Zunino Diego , Cirillo Bruno , Wezel Filippo Carlo , Breschi Stefano 
Published: July 2023

AbstractNew entrants and incumbent firms rely on new knowledge to innovate and compete in the market. One way to acquire new knowledge is through the recruitment of new employees from competitors, a phenomenon popularly known as “poaching.” Digital labor platforms are widely used by firms for this aim. We argue that job titles represent the first and most visible public source of information about knowledge workers and thus play a key role in navigating the vast spectrum of competencies available in digital platforms. Our analyses of the career trajectories of 11,644 knowledge workers in the United States between 2004 and 2014 suggest that increases in the ambiguity of a job title claimed by an employee are negatively associated with the likelihood of the employee being hired by a new employer. This finding appears stronger in the case of transitions to incumbent firms rather than new entrants. In the concluding section of the paper, we take stock of the various analyses presented and reflect on the potential role of job titles in the strategic management of human capital.
A unified approach to maximum-norm a posteriori error estimation for second-order time discretizations of parabolic equations
Authors: Linβ Torsten , Ossadnik Martin , Radojev Goran 
Published: July 2023

Abstract
A class of linear parabolic equations is considered. We derive a common framework for the a posteriori error analysis of certain second-order time discretizations combined with finite element discretizations in space. In particular, we study the Crank–Nicolson method, the extrapolated Euler method, the backward differentiation formula of order 2, the Lobatto IIIC method and a two-stage SDIRK method. We use the idea of elliptic reconstructions and certain bounds for the Green’s function of the parabolic operator.
Accumulation of Immunity in Heavy-Tailed Sexual Contact Networks Shapes Mpox Outbreak Sizes
Authors: Murayama Hiroaki , Pearson Carl A B , Abbott Sam , Miura Fuminari , Jung Sung-mok , Fearon Elizabeth , Funk Sebastian , Endo Akira 
Published: July 2023

Abstract
Many countries affected by the global outbreak of mpox in 2022 have observed a decline in cases. Our mathematical model accounting for heavy-tailed sexual partnership distributions suggests that mpox epidemics can hit the infection-derived herd immunity threshold and begin to decline, with &lt;1% of sexually active men who have sex with men infected regardless of interventions or behavioral changes. We consistently found that many countries and US states experienced an epidemic peak, with cumulative cases of around 0.1% to 0.5% among men who have sex with men. The observed decline in cases may not necessarily be attributable to interventions or behavioral changes primarily.
Serial Quantitation of Plasma Microbial Cell-Free DNA Before and After Diagnosis of Pulmonary Invasive Mold Infections After Hematopoietic Cell Transplant
Authors: Heldman Madeleine R , Ahmed Asim A , Liu Winnie , Vo Alythia , Keane-Candib Jacob , Stevens-Ayers Terry , Boeckh Michael , Blauwkamp Timothy A , Fisher Cynthia E , Hill Joshua A 
Published: July 2023

Abstract

Background
Plasma microbial cell-free DNA sequencing (mcfDNA-Seq) is a noninvasive test for microbial diagnosis of invasive mold infection (IMI). The utility of mcfDNA-Seq for predicting IMI onset and the clinical implications of mcfDNA concentrations are unknown.

Methods
We retrospectively tested plasma from hematopoietic cell transplant (HCT) recipients with pulmonary IMI and ≥1 mold identified by mcfDNA-Seq in plasma collected within 14 days of clinical diagnosis. Samples collected from up to 4 weeks before and 4 weeks after IMI diagnosis were evaluated using mcfDNA-Seq.

Results
Thirty-five HCT recipients with 39 IMIs (16 Aspergillus and 23 non-Aspergillus infections) were included. Pathogenic molds were detected in 38%, 26%, 11%, and 0% of samples collected during the first, second, third, and fourth week before clinical diagnosis, respectively. In non-Aspergillus infections, median mcfDNA concentrations in samples collected within 3 days of clinical diagnosis were higher in infections with versus without extrapulmonary spread (4.3 vs 3.3 log10 molecules per microliter [mpm], P = .02), and all patients (8/8) with mcfDNA concentrations &gt;4.0 log10 mpm died within 42 days after clinical diagnosis.

Conclusions
Plasma mcfDNA-Seq can identify pathogenic molds up to 3 weeks before clinical diagnosis of pulmonary IMI. Plasma mcfDNA concentrations may correlate with extrapulmonary spread and mortality in non-Aspergillus IMI.
Contributions of the N-terminal flanking residues of an antigenic peptide from the Japanese cedar pollen allergen Cry j 1 to the T-cell activation by HLA-DP5
Authors: Kusano Seisuke , Ueda Sho , Oryoji Daisuke , Toyoumi Aya , Hashimoto-Tane Akiko , Kishi Hiroyuki , Hamana Hiroshi , Muraguchi Atsushi , Jin Hui , Arase Hisashi , Miyadera Hiroko , Kishikawa Reiko , Yoshikai Yasunobu , Yamada Hisakata , Yamamoto Ken , Nishimura Yasuharu , Saito Takashi , Sasazuki Takehiko , Yokoyama Shigeyuki 
Published: July 2023

Abstract
Cry j 1 is a major allergen present in Japanese cedar (Cryptomeria japonica) pollens. Peptides with the core sequence of KVTVAFNQF from Cry j 1 (‘pCj1’) bind to HLA-DP5 and activate Th2 cells. In this study, we noticed that Ser and Lys at positions −2 and −3, respectively, in the N-terminal flanking (NF) region to pCj1 are conserved well in HLA-DP5-binding allergen peptides. A competitive binding assay showed that the double mutation of Ser(–2) and Lys(–3) to Glu [S(P–2)E/K(P–3)E] in a 13-residue Cry j 1 peptide (NF-pCj1) decreased its affinity for HLA-DP5 by about 2-fold. Similarly, this double mutation reduced, by about 2-fold, the amount of NF-pCj1 presented on the surface of mouse antigen-presenting dendritic cell line 1 (mDC1) cells stably expressing HLA-DP5. We established NF-pCj1-specific and HLA-DP5-restricted CD4+ T-cell clones from HLA-DP5 positive cedar pollinosis (CP) patients, and analyzed their IL-2 production due to the activation of mouse TG40 cells expressing the cloned T-cell receptor by the NF-pCj1-presenting mDC1 cells. The T-cell activation was actually decreased by the S(P–2)E/K(P–3)E mutation, corresponding to the reduction in the peptide presentation by this mutation. In contrast, the affinity of NF-pCj1·HLA-DP5 for the T-cell receptor was not affected by the S(P–2)E/K(P–3)E mutation, as analyzed by surface plasmon resonance. Considering the positional and side-chain differences of these NF residues from previously reported T-cell activating sequences, the mechanisms of enhanced T-cell activation by Ser(–2) and Lys(–3) of NF-pCj1 may be novel.
Neoclassical Realism as a Theory for Correcting Mistakes: What State X Should Do Next Tuesday
Authors: Juneau Thomas 
Published: July 2023

Abstract
Neoclassical realism has carved a unique niche by offering a theoretically derived and empirically rich foreign policy analysis framework. Over the years, it has branched out as a theory of mistakes (Type I), a theory of foreign policy (Type II), and a theory of international politics (Type III). This article proposes another challenge to consolidate its offer of a progressive research agenda to position it as a theory for correcting mistakes. The theory of mistakes version differentiates ideal from actual foreign policy. The ideal corresponds to foreign policy that follows the pressures and incentives of the international system; structural realism, the basis for this optimal baseline, is here viewed as a normative theory. If there is a gap between the ideal baseline and the actual outcome, then foreign policy is sub-optimal and therefore costly. According to neoclassical realists, this is the result of the intervention of domestic political processes hijacking foreign policy. It follows that pointing out how to reduce the distorting impact of these domestic variables should help steer foreign policy toward optimality. By identifying the negative consequences that follow from a sub-optimal foreign policy, a theory for correcting mistakes also opens the door to developing prescriptions to manage the inevitable fallout.
Escaping or Reinforcing Hierarchies? Norm Relations in Transitional Justice
Authors: Carvajalino Jinú , Davidović Maja 
Published: July 2023

AbstractThe global project of transitional justice (TJ) traditionally has been packaged in a multi-pillar model with criminal justice, truth recovery, reparations, institutional reform, and memorialization, and the norms they enshrine, seemingly presented as interventions of equivalent status at the level of policy. This article aims to enhance the theorizing on TJ as a “norm cluster” by comparatively examining the relations between the norms found in the cluster in transitional practices in Colombia and Bosnia and Herzegovina. We claim that the relations between the norms of TJ are hierarchically organized, with the anti-impunity norm being positioned as normatively superior. Through an analysis of TJ processes in the two countries in the past three decades, we discuss how such a hierarchy was established, secured, and challenged. Our findings show that hierarchical relations arise primarily due to legitimacy concerns and are manifested as changes in the internal structure of the anti-impunity norm whereby its prescribed behaviors or measures, i.e., criminal trials, seek to fulfill a range of new values. We argue that, in search for ownership and legitimacy, political actors have overemphasized the role of criminal trials by increasing their “social weight” and positioned them as indispensable for achieving the values of truth, reconciliation, and non-recurrence, disturbing the internal structures and co-opting the spaces of other measures in the TJ norm cluster. Such normative superiority of anti-impunity is significant and detrimental for the TJ global project. It has resulted in other TJ mechanisms being weakened by or dependent on judicial procedures, and it has enhanced competing and revisionist truth-making while promoting a narrow understanding of accountability. Ultimately, we establish that the normative superiority of criminal justice continues to challenge the prospects of complex and comprehensive TJ and that the place of anti-impunity in the norm cluster should be rethought.
Using biological traits to assess diet selection: the case of the Pyrenean Desman
Authors: Esnaola Amaiur , Larrañaga Aitor , González-Esteban Jorge , Elosegi Arturo , Aihartza Joxerra 
Published: July 2023

Abstract
Traditionally, researchers have assessed diet selection by comparing consumed versus available taxa. However, taxonomic assignment is probably irrelevant for predators, who likely base their selection on characteristics including prey size, habitat, or behavior. Here, we use an aquatic insectivore, the threatened Pyrenean Desman (Galemys pyrenaicus), as a model species to assess whether biological traits help unravel the criteria driving food and habitat preferences. We reanalyzed data from a previous taxonomy-based study of prey selection in two contrasting streams, one with excellent conservation status and the other affected by diversion for hydropower and forestry. Available and consumed prey were characterized according to nine biological traits, and diet selection was estimated by comparing availability—measured from Surber net samples, and consumption—analyzed by metabarcoding desman feces. Traits offered a biologically coherent image of diet and almost identical selection patterns in both streams, depicting a highly specialized rheophilic predator. Desmans positively selected prey with a preference for fast flow and boulder substrate, indicating their preferred riffle habitat. On the other hand, they positively selected prey with larger but not the largest potential size, living in the water column or the litter, and not inside sediments. They also chose agile prey, swimmers or prey attached to the substrate, prey with high body flexibility, and prey living exposed and clustered in groups. Overall, our results offer a picture of desman diet preference and point to biological traits as being better than taxonomic identity to describe the diet preference of consumers.
Leveraging national and global political determinants of health to promote equity in cancer care
Authors: Dee Edward Christopher , Eala Michelle Ann B , Robredo Janine Patricia G , Ramiah Duvern , Hubbard Anne , Ho Frances Dominique V , Sullivan Richard , Aggarwal Ajay , Booth Christopher M , Legaspi Gerardo D , Nguyen Paul L , Pramesh C S , Grover Surbhi 
Published: July 2023

Abstract
Health and politics are deeply intertwined. In the context of national and global cancer care delivery, political forces—the political determinants of health—influence every level of the cancer care continuum. We explore the “3-I” framework, which structures the upstream political forces that affect policy choices in the context of actors' interests, ideas, and institutions, to examine how political determinants of health underlie cancer disparities. Borrowing from the work of PA Hall, M-P Pomey, CJ Ho, and other thinkers, interests are the agendas of individuals and groups in power. Ideas represent beliefs or knowledge about what is or what should be. Institutions define the rules of play. We provide examples from around the world: Political interests have helped fuel the establishment of cancer centers in India and have galvanized the 2022 Cancer Moonshot in the United States. The politics of ideas underlie global disparities in cancer clinical trials—that is, in the distribution of epistemic power. Finally, historical institutions have helped perpetuate disparities related to racist and colonialist legacies. Present institutions have also been used to improve access for those in greatest need, as exemplified by the Butaro Cancer Center of Excellence in Rwanda. In providing these global examples, we demonstrate how interests, ideas, and institutions influence access to cancer care across the breadth of the cancer continuum. We argue that these forces can be leveraged to promote cancer care equity nationally and globally.
Effect of madecassoside in reducing oxidative stress and blood glucose in streptozotocin–nicotinamide-induced diabetes in rats
Authors: Tan Swee Ching , Rajendran Ramkumar , Bhattamisra Subrat Kumar , Krishnappa Purushotham , Davamani Fabian , Chitra Ebenezer , Ambu Stephen , Furman Brian , Candasamy Mayuren 
Published: July 2023

Abstract

Objectives
Madecassoside (MAD) is a triterpenoid constituent of Centella asiatica (L.) Urb., an ethnomedical tropical plant, extracts of which were shown to reduce blood glucose in experimental diabetes. This study examines MAD for its anti-hyperglycaemic effects and tests the hypothesis that it reduces the blood glucose in experimentally induced diabetic rats by protecting the β-cells.

Methods
Diabetes was induced using streptozotocin (60 mg/kg, i.v.) followed by nicotinamide (210 mg/kg, intraperitoneal (i.p.)). MAD (50 mg/kg) was administered orally for 4 weeks, commencing 15 days after induction of diabetes; resveratrol (10 mg/kg) was used as a positive control. Fasting blood glucose, plasma insulin, HbA1c, liver and lipid parameters were measured, along with antioxidant enzymes and malondialdehyde as an index of lipid peroxidation; histological and immunohistochemical studies were also undertaken.

Key findings
MAD normalized the elevated fasting blood glucose levels. This was associated with increased plasma insulin concentrations. MAD alleviated oxidative stress by improving enzymatic antioxidants and reducing lipid peroxidation. Histopathological examination showed significant recovery of islet structural degeneration and an increased area of islets. Immunohistochemical staining showed increased insulin content in islets of MAD-treated rats.

Conclusions
The results demonstrate an antidiabetic effect of MAD associated with preservation of β-cell structure and function.
Albiflorin alleviation efficacy in osteoarthritis injury using in-vivo and in-vitro models
Authors: Zhou Feng , Liu Jianfan , Xu Xuezheng , Luo Yi , Yang Shuo 
Published: July 2023

Abstract

Objectives
Osteoarthritis seriously affects the daily life of people. Albiflorin (AF) has anti-inflammatory and antioxidant functions in various human diseases. This study aimed to clarify the function and mechanism of AF in osteoarthritis.

Methods
The functions of AF on rat chondrocyte proliferation and apoptosis, inflammatory response, oxidative stress and extracellular matrix (ECM) degradation in rat chondrocytes induced by interleukin-1beta (IL-1β) were evaluated by Western blot, immunofluorescence, flow cytometry and enzyme-linked immunosorbent assay. The mechanism of AF on the IL-1β induced rat chondrocyte injury was investigated by multiple experiments in vitro. Meanwhile, the AF function in vivo was assessed using haematoxylin-eosin staining, Alcian blue, Safranin O/Fast green staining, immunohistochemical analysis and TUNEL assay.

Key findings
Functionally, AF accelerated the rat chondrocyte proliferation and repressed cell apoptosis. Meanwhile, AF reduced the inflammatory response, oxidative stress and ECM degradation in rat chondrocytes caused by IL-1β. Mechanistically, the receptor activator of the NF-kappaB ligand (RANKL), an activator for the NF-κB signalling pathway, partially reversed the alleviating effect of AF on IL-1β-induced chondrocyte injury. Furthermore, the in-vitro results confirmed that AF exerted protective properties against osteoarthritis injury in vivo.

Conclusion
Albiflorin relieved osteoarthritis injury in rats by inactivating the NF-κB pathway.
Durable biventricular assist device support for 1212 days as a bridge to heart transplantation
Authors: Sharaf Omar M , Bilgili Ahmet , Ahmed Mustafa M , Bleiweis Mark S , Jeng Eric I 
Published: July 2023

Abstract
Experience with durable biventricular assist devices (BiVADs) as a bridge to heart transplantation (HTx) is limited, particularly in women. A 41-year-old woman with biventricular failure complicated by cardiogenic shock underwent durable concurrent BiVAD implantation and was supported for 1212 days as a bridge to HTx. During BiVAD support, she experienced bacteremia (day 1030 of support), appropriately managed with intravenous antibiotics. She is alive and well, 1479 days from BiVAD implantation and 267 days from orthotopic HTx. Strategies contributing to successful prolonged support include concurrent BiVAD implantation, aggressive cardiac rehabilitation, diet management for weight loss and frequent interval surveillance.
Kaposi sarcoma presenting as small bowel obstruction
Authors: Tian Jane , Janbey Selma , Hassanesfahani Maryam , Bhatia Shubham , Louis Martine A , Khan Noman 
Published: July 2023

Abstract
Kaposi sarcoma (KS) is a low-grade tumor of the vascular endothelium. The majority of individuals affected have advanced human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). The disease typically manifests as cutaneous lesions but reports have shown that systemic disease is not uncommon. Because gastrointestinal KS is often asymptomatic, it is likely underdiagnosed. Those with symptoms can present with vague abdominal pain, nausea/vomiting or anemia. Rarely the tumors can cause bowel obstruction or perforation. We present a case of small bowel obstruction cause by KS tumors in a young transgender male to female patient with poorly controlled AIDS, supported by literature review of the clinical presentation, diagnosis and treatment recommendations.
A single amino acid change led to structural and functional differentiation of PvHd1 to control flowering in switchgrass
Authors: Choi Soyeon , Prabhakar Pradeep K , Chowdhury Ratul , Pendergast Thomas H , Urbanowicz Breeanna R , Maranas Costas , Devos Katrien M 
Published: July 2023

Abstract
Switchgrass, a forage and bioenergy crop, occurs as two main ecotypes with different but overlapping ranges of adaptation. The two ecotypes differ in a range of characteristics, including flowering time. Flowering time determines the duration of vegetative development and therefore biomass accumulation, a key trait in bioenergy crops. No causal variants for flowering time differences between switchgrass ecotypes have, as yet, been identified. In this study, we mapped a robust flowering time quantitative trait locus (QTL) on chromosome 4K in a biparental F2 population and characterized the flowering-associated transcription factor gene PvHd1, an ortholog of CONSTANS in Arabidopsis and Heading date 1 in rice, as the underlying causal gene. Protein modeling predicted that a serine to glycine substitution at position 35 (p.S35G) in B-Box domain 1 greatly altered the global structure of the PvHd1 protein. The predicted variation in protein compactness was supported in vitro by a 4 °C shift in denaturation temperature. Overexpressing the PvHd1-p.35S allele in a late-flowering CONSTANS-null Arabidopsis mutant rescued earlier flowering, whereas PvHd1-p.35G had a reduced ability to promote flowering, demonstrating that the structural variation led to functional divergence. Our findings provide us with a tool to manipulate the timing of floral transition in switchgrass cultivars and, potentially, expand their cultivation range.
Conventional and new genetic resources for an eggplant breeding revolution
Authors: Gramazio Pietro , Alonso David , Arrones Andrea , Villanueva Gloria , Plazas Mariola , Toppino Laura , Barchi Lorenzo , Portis Ezio , Ferrante Paola , Lanteri Sergio , Rotino Giuseppe Leonardo , Giuliano Giovanni , Vilanova Santiago , Prohens Jaime 
Published: July 2023

Abstract
Eggplant (Solanum melongena) is a major vegetable crop with great potential for genetic improvement owing to its large and mostly untapped genetic diversity. It is closely related to over 500 species of Solanum subgenus Leptostemonum that belong to its primary, secondary, and tertiary genepools and exhibit a wide range of characteristics useful for eggplant breeding, including traits adaptive to climate change. Germplasm banks worldwide hold more than 19 000 accessions of eggplant and related species, most of which have yet to be evaluated. Nonetheless, eggplant breeding using the cultivated S. melongena genepool has yielded significantly improved varieties. To overcome current breeding challenges and for adaptation to climate change, a qualitative leap forward in eggplant breeding is necessary. The initial findings from introgression breeding in eggplant indicate that unleashing the diversity present in its relatives can greatly contribute to eggplant breeding. The recent creation of new genetic resources such as mutant libraries, core collections, recombinant inbred lines, and sets of introgression lines will be another crucial element and will require the support of new genomics tools and biotechnological developments. The systematic utilization of eggplant genetic resources supported by international initiatives will be critical for a much-needed eggplant breeding revolution to address the challenges posed by climate change.
An Atypical Cause of Hoarseness in a Patient With Thyroid Nodules
Authors: Gandhi Shruti M , Paal Edina , Nylen Eric S 
Published: July 2023

ABSTRACT
Hoarseness due to vocal fold paresis (VFP) has a multitude of etiologies including systemic lupus erythematosus (SLE). During a clinical evaluation of a 58-year-old woman with long-standing hoarseness, an incidental finding of thyroid nodules was found to have VFP. Direct laryngoscopy and vocal fold biopsy confirmed the source was an inflammatory process involving the cricoarytenoid joint of the right hemilarynx. A presumptive diagnosis of SLE was made 3 years before meeting the clinical criteria of overt SLE. The VFP debut of SLE is extremely rare, and a literature review includes a handful of case reports (4 of a total of 37) since 1959. Only partial recovery of laryngeal function using glucocorticoids and Plaquenil was accomplished in the current case.