bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basis for the formulation of Bacillus subtilis SPB1 biosurfactant to achieve low interfacial tension and high emulsification activities: development of a bio-based formula with potential use for personal care products
Authors: Bouassida Mouna , Fourati Nada , Ines Mnif , Ghribi Dhouha 
Published: April 2023

Abstract
Thanks to their multifunctional properties, such as foaming, emulsifying and skin hydrating activities biosurfactants are potentially used in the cosmetic industry. In the present work, firstly, skin cream formulations using chemical surfactant agents and lipopeptide biosurfactants isolated from Bacillus subtilis SPB1 were investigated. The efficiency of the selected formula, containing 15% biosurfactant, was tested and its physicochemical properties were satisfying. In fact, it shows a spreading ability of 23 mm, a water activity of 0.72 and a pH value of 5. In addition, its biological activities were interesting showing a zone of inhibition against Gram-positive bacteria ranging from 8 to 15 mm. Moreover, it presents an antiradical effect against diphenyl-1-picrylhydrazyl (DPPH) with an IC50 of the order of 68 mg/mL. Second, seeking a highly stable SPB1 biosurfactant formulation for an easy commercial trend, a combination of biosurfactant, Gum Arabic (GA) and glycerol was optimized using the Box–Behnken (BB) design. As analysed, the model predicts an optimal value of the surface tension (ST) equal to 40.18 ± 0.39 mN/m when the respective values of the percentages of SPB1 BioS, glycerol and GA are equal to 72.62, 7.5 and 1.5%. Under these conditions, the emulsification index (EI)-24% is around 81.76 ± 0.14%.
A Comprehensive Review on the Importance of MiRNA-206 in the Animal
Model and Human Diseases
Authors: Qi Wang , Guan Wei 
Published: April 2023

Abstract:
MicroRNA-206 (miR-206) is a microRNA that is involved in many human diseases, such
as myasthenia gravis, osteoarthritis, depression, cancers, etc. Both inhibition effects and progression
roles of miR-206 have been reported for the past few years. High expression of miR-206 was observed
in patients with osteoarthritis, gastric cancer and epithelial ovarian cancer compared to normal people.
The study also showed that miR-206 promotes cancer progression in breast cancer patients and avascular
necrosis of the femoral head. Meanwhile, several studies have shown that expression levels of
miR-206 were down-regulated in laryngeal carcinoma cell multiplication, as well as in hepatocellular
carcinoma, non-small lung cancer and infantile hemangioma. Moreover, miR-206 was up-regulated in
the mild stage of amyotrophic lateral sclerosis patients and then down-regulated in the moderate and
severe stages, indicating that miR-206 has the double effects of starting and aggravating the disease. In
neuropsychiatric disorders, such as depression, miR-206 also plays an important role in the progression
of the disease; the level of miR-206 is most highly expressed in the brains of patients with depression.
In the current review, we summarize the role of miR-206 in various diseases, and miR-206 may
be developed as a new biomarker for diagnosing diseases in the near future.
Subthreshold Doses of Inflammatory Mediators potentiate One Another to
Elicit Reflex Cardiorespiratory Responses in Anesthetized Rats
Authors: Revand Ravindran , Singh Sanjeev K. , Muthu Madaswamy S. 
Published: April 2023

Background:
Reflex cardio-vascular and respiratory (CVR) alterations evoked by intraarterial
instillation of nociceptive agents are termed vasosensory reflexes. Such responses elicited
by optimal doses of inflammatory mediators have been described in our earlier work.

Objective:
The present study was designed to evaluate the interactions between subthreshold doses
of inflammatory mediators on perivascular nociceptive afferents in urethane anesthetized rats.

Methods:
Healthy male adult rats (Charles-Foster strain) were anesthetized with an intraperitoneal
injection of urethane. After anesthesia, the right femoral artery was cannulated. Respiratory
movements, blood pressure, and electrocardiogram were recorded. The interactions between subthreshold
doses of algogens in the elicitation of vasosensory reflex responses were studied by instillation
of bradykinin (1 nM) and histamine (100 μM) into the femoral artery one after the other,
in either temporal combination in separate groups of rats. The CVR responses obtained in these
groups were then compared with the responses produced by 100 μM histamine and 1 nM bradykinin
in saline-pretreated groups, which served as control.

Results:
Subthreshold doses of histamine elicited transient tachypnoeic, hyperventilatory, hypotensive,
and bradycardiac responses, in rats pretreated with subthreshold doses of bradykinin [p <
0.01, two-sided Dunnett’s test] but not in saline pretreated groups [p > 0.05, two-sided Dunnett’s
test]. Similar responses were elicited by bradykinin after histamine pretreatment compared to the
saline-pretreated group. Furthermore, CVR responses produced by histamine in the bradykininpretreated
group were greater in magnitude as compared to bradykinin-induced responses in the
histamine-pretreated group [p < 0.05, two-sided Dunnett’s test].

Conclusion:
The present study demonstrates that both bradykinin and histamine potentiate one
another in the elicitation of vasosensory reflex responses, and bradykinin is a better potentiator
than histamine at the level of perivascular nociceptive afferents in producing reflex CVR changes.
Two Cases with 17-alpha Hydroxylase Deficiency Misdiagnosed as Primary
Aldosteronism
Authors: Akkus Gamze 
Published: April 2023

Aim:
Lack of CYP17A1 prevents sex steroid biosynthesis, yielding a female phenotype in 46, XY males and sexual infantilism in both sexes; overproduction of 11-deoxycorticosterone (DOC) in the zona fasciculata typically causes mineralocorticoid hypertension. In this study, we report two cases of severe hypokalemia, hyperaldosteronism, and sexual infantilism.

Case Presentation:
Case 1 admitted severe hypertension and hypokalemia with female external genitalia with 46, XY. The patient also had right adrenal masses of 35*30 mm diameters. Case 2 was presented with delayed pubertal development with 46, XX genotype. In addition, she had severe hypertension and hypokalemia with nodular surrenal hyperplasia in her abdomen imaging.

Methods:
Further hormonal and biochemical results were followed as elevated adrenocorticotropic hormone (ACTH) levels, low serum cortisol, 17 hydroxy progesterone (17 OHP) and dehydroepiandrosterone sulphate (DHESO4) and estradiol (E2 ) levels in both cases.

Results:
Genetical analyses confirmed 17 OHP deficiency in both cases.

Conclusion:
The condition of patients with 17 alpha-hydroxylase deficiency may substantially resemble primary hyperaldosteronism and must be considered in patients as primary hypogonadism (and) associated with mineralocorticoid hypertension.
Toward Optimum Light Curing of Resin Composite Restorations: A survey on Current Awareness and Practice among General Dentists in Saudi Arabia
Authors: Haridy Rasha , Abdalla Moamen A. , Alkhalaf Rana , Albishri Rana , Alenizy Anwar Mogbel , Zeeshan Mohammad , Aldegheishem Alhanoof , AlSheikh Rasha , Elgezawi Moataz 
Published: April 2023

Introduction:
This study aimed to assess the current awareness and practices of resin composite light curing of general dental practitioners (GDPs) in Saudi Arabia and to set several evidence-based recommendations to improve the quality of the outcome of concern.

Methods:
An online questionnaire was created. Two hundred and fifty email invitations were sent to GDPs appointed in general governmental hospitals in five main cities in Saudi Arabia to join the survey voluntarily and anonymously. The survey consisted of 24 questions classified into the following domains: 1-Demographic criteria 2- frequency and technical aspects of resin composites application 3- criteria of the currently used light curing units and curing light. Descriptive statistics and chi-square test were used to analyse the obtained responses.

Results:
One hundred and fifty-six responses were received. A significant number of GDPs are significantly satisfied with the quality of their light curing, not aware of the thermal hazards of light curing, and do not check power output of their LCUs (light curing units) (P<0.05). An insignificant number of respondents use eye shields for eye protection during light curing.

Conclusion:
There was no uniform light curing protocol followed by respondent GDPs. GDPs in Saudi Arabia should improve their knowledge and clinical skills of light-curing resin composite.
TRAIL and EGFR Pathways Targeting microRNAs are Predominantly Regulated in Human Diabetic Nephropathy
Authors: Rai Bhuvnesh , Pande Akshara , Tiwari Swasti 
Published: April 2023

Background:Unbiased microRNA profiling of renal tissue and urinary extracellular vesi-cles (uEVs) from diabetic nephropathy (DN) subjects may unravel novel targets with diagnostic and therapeutic potential. Here we used the miRNA profile of uEVs and renal biopsies from DN subjects available on the GEO database.Methods:The miR expression profiles of kidney tissue (GSE51674) and urinary exosomes (GSE48318) from DN and control subjects were obtained by GEO2R tools from Gene Expression Om-nibus (GEO) databases. Differentially expressed miRNAs in DN samples, relative to controls, were identified using a bioinformatic pipeline. Targets of miRs commonly regulated in both sample types were predicted by miRWalk, followed by functional gene enrichment analysis. Gene targets were iden-tified by MiRTarBase, TargetScan and MiRDB.Results:Eight miRs, including let-7c, miR-10a, miR-10b and miR-181c, were significantly regulated in kidney tissue and uEVs in DN subjects versus controls. The top 10 significant pathways targeted by these miRs included TRAIL, EGFR, Proteoglycan syndecan, VEGF and Integrin Pathway. Gene target analysis by miRwalk upon validation using ShinyGO 70 targets with significant miRNA-mRNA inter-action.Conclusion:In silico analysis showed that miRs targeting TRAIL and EGFR signaling are predomi-nately regulated in uEVs and renal tissue of DN subjects. After wet-lab validation, the identified miRs- target pairs may be explored for their diagnostic and/or therapeutic potential in diabetic nephropathy.
The Effect of COVID Convalescent Plasma on Hospital Stay: A
Retrospective Observational Study from a Tertiary Care Hospital
in North India
Authors: Pandey Prashant , Ranjan Shweta , Setya Divya , Kumari Supriya , Mandal Saikat 
Published: April 2023

Introduction:
COVID convalescent plasma (CCP) has been used as standard of
care in patients all over the world. CCP is plasma collected from recently infected and currently
recovered COVID-19 patients, which contains antiviral antibodies that can be used to treat patients
with COVID-19. Several studies have shown a shorter hospital stay and lower mortality in
patients treated with convalescent plasma in comparison with those not treated with it.

Objectives:
This study aims to determine the effect of COVID convalescent plasma (CCP)
on the length of hospital stay in symptomatic patients and to determine outcome of the disease
in patients who were administered CCP

Methods:
This was a retrospective observational study done at a tertiary health care centre
from July 2020 to May 2021, including patients who received CCP during the course of their
stay in the hospital.

Results:
Among 257 participants, the patients with multiple comorbidities who were administered
CCP had the longest average length of stay in the hospital which was 15 days, out of
which, 92 (35.8%) patients were discharged while 9 (3.5%) patients died. Also, the maximum
number of deaths was observed in those patients who had no associated comorbidity, being 11
(4.3%). It was observed that earlier administration of CCP in patients (< 5 days from symptom
onset) was associated with a higher number of discharges as compared to deaths.

Conclusion:
Our study indicates that CCP may be efficient in treating COVID-19 patients if
given in early course of the disease.
TikTok and #OccupationalTherapy: Cross-sectional Study
Authors: Chasca Whitney , Nerada Samantha , Zenone Marco , Barbic Skye 
Published: April 2023

Background
Medical providers use the short-form video social media platform TikTok to share information related to their scope of practice and insights about their professions. Videos under the hashtag #occupationaltherapy on TikTok have over 100 million views, but there is no evidence investigating how occupational therapy information and knowledge are shared on the platform.

Objective
The purpose of this cross-sectional study is to describe TikTok content with the hashtag #occupationaltherapy and investigate how occupational therapy is portrayed.

Methods
We performed a content analysis on the top 500 TikTok videos under the hashtag #occupationaltherapy. We analyzed occupational therapy content themes (occupational therapy intervention, education, student training, universal design, and humor), practice settings (pediatrics, generalists, dementia, hand therapy, neurology, occupational therapy students, older adults, mental health, and unknown), and sentiments (positive, negative, and neutral).

Results
The videos in our sample (n=500) received 175,862,994 views. The 2 most prevalent content areas were education (n=210) and occupational therapy interventions (n=146). The overall sentiment of the videos was positive (n=302). The most frequently observed practice settings in the videos were pediatrics (n=131) and generalists (n=129). Most videos did not state that it was occupational therapy (n=222) or misused the hashtag (n=131).

Conclusions
TikTok has the potential for occupational therapists to share innovations, build communities of practice, and engage in collaborative efforts to share information about occupational therapists’ unique roles with diverse populations. Future research is needed to monitor the quality of information and debunk inaccuracies.
Pengalaman Perawat dalam Melakukan Resusitasi Jantung Paru pada Pasien Covid-19
Authors: Aty Yoany Maria Vianney B. , Blasius Gadur , Herwanti Elisabeth , Selasa Pius , Gonsalves Dominggos , Nuzula Firdawsyi , Muhtar Muhtar 
Published: April 2023

Latar Belakang: Tantangan perawat pada masa pandemi Covid-19 saat memberikan bantuan pasien yang mengalami henti jantung adalah penularan virus Covid-19. Perawat yang melakukan Resusitasi Jantung Paru (RJP) dengan menggunakan APD lengkap masih mungkin mengalami penularan virus yang bisa melalui droplet atau aerosol dari pasien yang terdapat di udara yang masuk melalui celah yang terbentuk tanpa sengaja oleh perawat saat bekerja.Tujuan: Mengeksplorasi pengalaman perawat dalam melakukan RJP pada pasien Covid-19 di ruang IGD, ICU, dan ICCU RSUD Prof. W. Z Johannes Kupang.Metode: Penelitian ini adalah kualitatif dengan jenis fenomenologi. Indeepth interview dilakukan untuk menggali pengalaman perawat dalam melakukan RJP pada pasien Covid-19 yang mengalami henti jantung dan napas. Jumlah partisipan sebanyak 4 orang.Hasil: Penelitian menemukan 6 tema yakni keputusan melakukan RJP pasien, keterbatasan gerak dan mudah lelah, kesulitan memonitor kondisi pasien, cemas tertular Covid-19, rasa empati, dan kerja sama tim.Kesimpulan: Tindakan RJP pasien terkonfirmasi Covid-19 memerlukan keputusan yang tepat. Selama tindakan ini perawat mengalami kelelahan, sulit mengecek kondisi pasien karena APD yang digunakan. Perawat juga merasa takut tertular. Namun, rasa empati kepada pasien membuat perawat melakukan tindakan RJP ini dengan baik yang didukung oleh kerja sama tim yang baik.
Dynamics of decline in industrial injuries
Authors: Korol’ Elena A. , Degaev Evgeniy N. 
Published: April 2023

Introduction. The authors analyze the dynamics of decline in industrial injuries in 2000 to 2021. According to the Federal Service for Labor and Employment, accidents at work became more frequent in 2021 relative to 2020. In the processing industry, construction, transportation and storage sectors, the largest number of fatalities was registered in the workplace, reaching 52.2 % of the total number of all fatal accidents. The purpose of the work is to study the set of parameters, affecting
the level of industrial injuries, and to identify the factors that contribute to reducing the number of violations of labor law requirements in occupational safety.

Materials and methods. Provisions of the Labor Code of the Russian Federation and Federal Law “On Special Evaluation of Working Conditions” No. 426 dated December 28, 2013, which set the occupational safety requirements and the procedure for the special evaluation of working conditions, are the basis for verifying statistical data on industrial injuries.

Results. Unsatisfactory production and workplace arrangements were the main causes of accidents in 2021 (31 % of the total number). 16 % of accidents, that involved grave consequences, occurred through the fault of employees (violation of work performance procedures and discipline of labor — 10 %, violations of the technology process — 6 %). More than 6,000 violations of the law were revealed as a result of a special evaluation of working conditions, and the total amount of charged penalties reached 2,641,900 rubles.

Conclusions. The dynamics of decline in industrial injuries in Russia in the context of 2000–2021 has a positive trend, but it is irregular. There was a slight increase in the number of fatalities at industrial facilities in 2007, 2010 and 2021. The main reason for an increase in industrial injuries in 2021 was a ban imposed on scheduled inspections due to the coronavirus infection. To reduce industrial injuries, it is necessary to toughen penalties for violations by employers of the requirements of the labor legislation, including those regulating the special evaluation of working conditions.
Some Implications of the Multifractal Informational Entropy
Authors: Gavriluț Gabriel , Agop Ștefana , Rusu Cristina-Marcela , Petrescu Tudor-Cristian , Ștefan Gavril , Oprea Iuliana 
Published: April 2023

Abstract
A new formulation of the informational entropy on multifractal manifolds is proposed. In such a context, some connections with known results from the dynamics of complex systems are presented: correlations of SL(2ℝ) groups with Hamiltonian formalism, simultaneous invariances between two groups (coordinate group and parametric group), linear harmonic oscillator/oscillator ensemble dynamics from the perspective of SL(2ℝ) groups, uncertainty relations on multifractal manifolds etc. Moreover, the existence of a multifractal perspective in the complex dynamics analysis allows direct correspondences with deep learning algorithms.
Gravitational Interaction Mediated by Classical Zero Point Field
Authors: Simaciu Ion , Borsos Zoltan , Dumitrescu Gheorghe , Drafta Viorel 
Published: April 2023

Abstract
By modeling the particle as a two-dimensional oscillator with the natural angular frequency equal to the Zitterbewegung frequency, the expression of the gravitational force between two particles is obtained. Gravitational force is the effect of the absorption-scattering of the CZPF background by the oscillators. The connection between the gravitational and the electrostatic interaction is obtained.
Political and Economic Aspects of Brexit Impact on Accounting Legislation in the UK – New Directions in Standards (GAAP UK and IFRS)
Authors: Shkulipa Liudmyla 
Published: April 2023

Abstract
Post-Brexit is currently being researched as not only an important geopolitical change but also as an economically conflicted period that constantly generates many issues in finance, accounting, and taxation. This paper aims to consider, identify and forecast – whether and what – the new directions for the development of IFRS and GAAP UK after Brexit. The research methods are based on a deductive research approach with elements of descriptive content analysis. The results of the study helped to determine the development direction of accounting in the UK after Brexit in the short term – the continued application of IFRS, adopted by the EU. However, it is obtained that the task of the British government – to harmonize its sovereignty with IFRS, taking into account the requirements of the EU – is being successfully implemented. So, the direction of the development of British accounting in the future – is the creation of its mechanism for the approval of national standards, controlled by the government. However, the British accounting system and IFRSs have many unresolved issues after Brexit that might be the subject of future studies.
Czech Corporate Effective Tax Rate as Investors Costs Changes with Times
Authors: Rohan Jan , Moravec Lukáš , Kukalová Gabriela , Ječmínek Jakub , Hinke Jana 
Published: April 2023

Abstract
When choosing the appropriate jurisdiction, trading companies need to consider many variables. This can include administrative burdens, the speed of establishment of a company, the granting of some degree of anonymity of ownership, and a friendly tax environment. This article is focused on finding the corporate effective tax rate in the Czech Republic in the period 2005–2017 with the database of the Czech tax administrator. In the light of the international tax law, the information concerning effective tax rates becoming necessary. The results of this study show that the nominal tax rate may not be decisive for the determination of the tax burden, as most countries allow the application of tax allowances and deductions and thus achieve virtually lower taxes.
The Right to Remedy Corporate Relations: A Question of Theoretical Certainty
Authors: Kostruba Anatoliy V. 
Published: April 2023

Abstract
Sometimes the interests of participants in corporate relations begin to contradict each other, corporate conflicts and corporate legal disputes arise, and often participants in the conflict abuse their rights, paralysing the company’s activities. In this case, it is necessary to find an appropriate solution for modifying the Ukrainian corporate law system and legislatively ensure effective remedies for the rights of participants in business companies. The following methods were used during the study: general scientific methods (concrete historical, Aristotelian, structural-functional, system-structural, etc.), special methods (comparative legal, modelling, system interpretation, legal technical), dialectical method of cognition, involvement of scientific tools of related humanities disciplines, a conceptual approach. The main steps to solve the problems of protecting the rights of participants and ensuring equal treatment were as follows: improving the legislation governing the activities of business companies; combining rules that ensure the rights of participants and guarantee their remedying under charters and internal documents. The judicial remedying of the company members’ rights on the territory of Ukraine remains ineffective, which, in turn, is attributed by researchers to the discretion of the judiciary and the inability of courts to interfere in certain issues within the framework of corporate conflicts. At the same time, in this context, it is advisable to adapt the positive practices legalised in Germany, which would allow modifying existing approaches to organising corporate relations and remedying the rights of participants. Moreover, the convergence of legal systems and legal regulation of corporate relations is one of the most noticeable trends in the development of corporate legislation around the world.