bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cuproptosis‐Inducible Chemotherapeutic/Cascade Catalytic Reactor System for Combating with Breast Cancer
Authors: Lee Song Yi , Seo Ji‐Hye , Kim Sungyun , Hwang ChaeRim , Jeong Da In , Park JiHye , Yang Mingyu , Huh Ji Won , Cho Hyun‐Jong 
Published: May 2023

AbstractCascade hydroxyl radical generating hydrogel reactor structures including a chemotherapeutic agent are invented for multiple treatment of breast cancer. Glucose oxidase (GOx) and cupric sulfate (Cu) are introduced for transforming accumulated glucose (in cancer cells) to hydroxyl radicals for starvation/chemodynamic therapy. Cu may also suppress cancer cell growth via cuproptosis‐mediated cell death. Berberine hydrochloride (BER) is engaged as a chemotherapeutic agent in the hydrogel reactor for combining with starvation/chemodynamic/cuproptosis therapeutic modalities. Moreover, Cu is participated as a gel crosslinker by coordinating with catechol groups in hyaluronic acid‐dopamine (HD) polymer. Controlling viscoelasticity of hydrogel reactor can extend the retention time following local injection and provide sustained drug release patterns. Low biodegradation rate of designed HD/BER/GOx/Cu hydrogel can reduce dosing frequency in local cancer therapy and avoid invasiveness‐related inconveniences. Especially, it is anticipated that HD/BER/GOx/Cu hydrogel system can be applied for reducing size of breast cancer prior to surgery as well as tumor growth suppression in clinical application.
Construction of 1D Heterogeneous Co/C@Ag Nws With Tunable Electromagnetic Wave Absorption And Shielding Performance
Authors: Jiang Chao , Wen Bianying 
Published: May 2023

AbstractIn this study, silver nanowires (Ag NWs) are synthesized at first, and then the 1D heterogeneous Co/C@Ag NWs with a kebab‐ and popsicle‐like microstructures are constructed by in situ growth ZIF‐67 on Ag NWs combined with calcination. Results show that the EM wave prevention performance of composites depends on the loading of Co/C particles threaded on the Ag NWs. The popsicle‐like structure with high Co/C loading gives Co/C@Ag NWs excellent EM wave absorption performance, which achieved a minimum reflection loss (RLmin) of −44.5 dB with a low filling of 30 wt.% in paraffin; while the kebab‐like structure with low Co/C loading shows good electromagnetic interference (EMI) shielding effectiveness (SET) of 30.2 dB at the same filler ratio. The enhanced EM wave absorption performance is attributed to the synergy of multiple energy dissipation mechanisms including dielectric loss, magnetic loss, polarization loss, eddy‐current loss, multiple reflection loss, as well as proper impedance matching; the good EMI shielding performance is mainly due to the conduction loss brought by the Ag NWs with ultrahigh conductivity. This work provides a reference for the design of electromagnetic wave prevention material with tuned absorption and shielding performance.
ISCOMs/MPLA‐Adjuvanted SDAD Protein Nanoparticles Induce Improved Mucosal Immune Responses and Cross‐Protection in Mice
Authors: Zhu Wandi , Park Jaeyoung , Pho Thomas , Wei Lai , Dong Chunhong , Kim Joo , Ma Yao , Champion Julie A. , Wang Bao‐Zhong 
Published: May 2023

AbstractThe epidemics caused by the influenza virus are a serious threat to public health and the economy. Adding appropriate adjuvants to improve immunogenicity and finding effective mucosal vaccines to combat respiratory infection at the portal of virus entry are important strategies to boost protection. In this study, a novel type of core/shell protein nanoparticle consisting of influenza nucleoprotein (NP) as the core and NA1‐M2e or NA2‐M2e fusion proteins as the coating antigens by SDAD hetero‐bifunctional crosslinking is exploited. Immune‐stimulating complexes (ISCOMs)/monophosphoryl lipid A (MPLA) adjuvants further boost the NP/NA‐M2e SDAD protein nanoparticle‐induced immune responses when administered intramuscularly. The ISCOMs/MPLA‐adjuvanted protein nanoparticles are delivered through the intranasal route to validate the application as mucosal vaccines. ISCOMs/MPLA‐adjuvanted nanoparticles induce significantly strengthened antigen‐specific antibody responses, cytokine‐secreting splenocytes in the systemic compartment, and higher levels of antigen‐specific IgA and IgG in the local mucosa. Meanwhile, significantly expanded lung resident memory (RM) T and B cells (TRM/BRM) and alveolar macrophages population are observed in ISCOMs/MPLA‐adjuvanted nanoparticle‐immunized mice with a 100% survival rate after homogeneous and heterogeneous H3N2 viral challenges. Taken together, ISCOMs/MPLA‐adjuvanted protein nanoparticles could improve strong systemic and mucosal immune responses conferring protection in different immunization routes.
Edge Graphitized Oxygen‐Rich Carbon Based on Stainless Steel‐Assisted High‐energy Ball Milling for High‐Capacity and Ultrafast Sodium Storage
Authors: Ning Meng , Wen Jiajun , Duan Zhihua , Cao Xiaoguo , Qiu Guojian , Zhang Minglu , Ye Xiaoji , Li Zhenghui , Zhang Haiyan 
Published: May 2023

AbstractOxygen doping is an effective strategy for constructing high‐performance carbon anodes in Na ion batteries; however, current oxygen‐doped carbons always exhibit low doping levels and high‐defect surfaces, resulting in limited capacity improvement and low initial Coulombic efficiency (ICE). Herein, a stainless steel‐assisted high‐energy ball milling is exploited to achieve high‐level oxygen doping (19.33%) in the carbon framework. The doped oxygen atoms exist dominantly in the form of carbon‐oxygen double bonds, supplying sufficient Na storage sites through an addition reaction. More importantly, it is unexpected that the random carbon layers on the surface are reconstructed into a quasi‐ordered arrangement by robust mechanical force, which is low‐defect and favorable for suppressing the formation of thick solid electrolyte interfaces. As such, the obtained carbon presents a large reversible capacity of 363 mAh g−1 with a high ICE up to 83.1%. In addition, owing to the surface‐dominated capacity contribution, an ultrafast Na storage is achieved that the capacity remains 139 mAh g−1 under a large current density of 100 A g−1. Such good Na storage performance, especially outstanding rate capability, has rarely been achieved before.
From Supramolecular Organic Cages to Porous Covalent Organic Frameworks for Enhancing Iodine Adsorption Capability by Fully Exposed Nitrogen‐Rich Sites
Authors: Cheng Ke , Li Hailian , Wang Jia‐Rui , Li Pei‐Zhou , Zhao Yanli 
Published: May 2023

AbstractIn order to overcome the limitations of supramolecular organic cages for their incomplete accessibility of active sites in the solid state and uneasy recyclability in liquid solution, herein a nitrogen‐rich organic cage is rationally linked into framework systems and four isoreticular covalent organic frameworks (COFs), that is, Cage‐TFB‐COF, Cage‐NTBA‐COF, Cage‐TFPB‐COF, and Cage‐TFPT‐COF, are successfully synthesized. Structure determination reveals that they are all high‐quality crystalline materials derived from the eclipsed packing of related isoreticular two‐dimensional frameworks. Since the nitrogen‐rich sites usually have a high affinity toward iodine species, iodine adsorption investigations are carried out and the results show that all of them display an enhancement in iodine adsorption capacities. Especially, Cage‐NTBA‐COF exhibits an iodine adsorption capacity of 304 wt%, 14‐fold higher than the solid sample packed from the cage itself. The strong interactions between the nitrogen‐rich sites and the adsorbed iodine species are revealed by spectral analyses. This work demonstrates that, utilizing the reticular chemistry strategy to extend the close‐packed supramolecular organic cages into crystalline porous framework solids, their inherent properties can be greatly exploited for targeted applications.
Zinc‐Doping Strategy on P2‐Type Mn‐Based Layered Oxide Cathode for High‐Performance Potassium‐ion Batteries
Authors: Zheng Yunshan , Li Junfeng , Ji Shunping , Hui Kwan San , Wang Shuo , Xu Huifang , Wang Kaixi , Dinh Duc Anh , Zha Chenyang , Shao Zongping , Hui Kwun Nam 
Published: May 2023

AbstractMn‐based layered oxide is extensively investigated as a promising cathode material for potassium‐ion batteries due to its high theoretical capacity and natural abundance of manganese. However, the Jahn–Teller distortion caused by high‐spin Mn3+(t2g3eg1) destabilizes the host structure and reduces the cycling stability. Here, K0.02Na0.55Mn0.70Ni0.25Zn0.05O2 (denoted as KNMNO‐Z) is reported to inhibit the Jahn–Teller effect and reduce the irreversible phase transition. Through the implementation of a Zn‐doping strategy, higher Mn valence is achieved in the KNMNO‐Z electrode, resulting in a reduction of Mn3+ amount and subsequently leading to an improvement in cyclic stability. Specifically, after 1000 cycles, a high retention rate of 97% is observed. Density functional theory calculations reveals that low‐valence Zn2+ ions substituting the transition metal position of Mn regulated the electronic structure around the MnO bonding, thereby alleviating the anisotropic coupling between oxidized O2− and Mn4+ and improving the structural stability. K0.02Na0.55Mn0.70Ni0.25Zn0.05O2 provided an initial discharge capacity of 57 mAh g−1 at 100 mA g−1 and a decay rate of only 0.003% per cycle, indicating that the Zn‐doped strategy is effective for developing high‐performance Mn‐based layered oxide cathode materials in PIBs.
Integrating near‐surface mounted SMA and externally bonded CFRP for concrete beams strengthened in flexure
Authors: Zhu Miaochang , Deng Jun , Jiang Jieliang 
Published: May 2023

AbstractThis study aims to develop a new hybrid strengthening approach for reinforced concrete beams by integrating near‐surface mounted shape memory alloys (SMAs) and externally bonded carbon fiber reinforced polymers (CFRPs). Due to the superelasticity and shape memory effect of SMAs, the proposed strengthening can enhance the flexural strength of concrete beams without compromising ductility. The recovery behavior of deformed SMA wires was studied to determine the optimal prestrain level that can achieve the highest recovery stress. Afterward, the flexural performance of concrete beams strengthened with SMA, CFRP and both was investigated by performing three‐point tests. The results show that integrating SMA and CFRP has more influence on increasing the ultimate moment than the cracking moment and leads to a more significant improvement in the ultimate moment than individually utilizing SMA and CFRP. Besides, the effect of the integrated approach on enhancing the ductility is more notable than increasing the ultimate moment. The ultimate moment was analytically calculated, and the calculations show reasonable agreement with experimental results. The effects of the SMA and CFRP amount on the ultimate moment were also clarified through a parametric study.
Quantification of data‐related uncertainty of spatially dense soil moisture patterns on the small catchment scale estimated using unsupervised multiple regression
Authors: Paasche Hendrik , Schröter Ingmar 
Published: May 2023

AbstractMultiple regression analysis is a valuable method to reduce information gaps in a sparse soil moisture data set by fusing its information content with those of densely mapped data sets. Regression analysis utilizing uncertain data results in an indeterminate regression model and indeterminate soil moisture predictions when applying the regression model. We employ an unsupervised multiple regression approaches, taking optimally located sparse soil moisture measurements directly as coefficients in a linear regression model. We propagate data uncertainties into our probabilistic soil moisture estimation results by embedding the regression in a Monte Carlo approach. The computed uncertainty defines the quantitative limit for information retrieval from the resultant ensemble of soil moisture maps. This raises doubts on the true presence of some prominent channel‐like features of increased soil moisture that are clearly visible in a previously and deterministically derived soil moisture map ignoring the presence of data uncertainty. The approach followed in this work is computationally simple and could be applied routinely to databases of similar size. Insufficient uncertainty communication by the data provider became the biggest obstacle in our efforts and led us to the insight that the geoscientific community may need to revise their standards with regard to uncertainty communication related to measured and processed data.
Histories of habitability from the oikoumene to the Anthropocene
Authors: Fleetwood Lachlan 
Published: May 2023

AbstractThe IPCC's Sixth Assessment Report warns in stark terms that many long inhabited parts of the world are now on course to become uninhabitable. As astronomers continue to search the universe for new habitable planets, it is equally essential to historicize the consequences of changing habitability on this one. This article reviews how scholars have engaged with the widely noted but rarely theorized categories of “habitability” and “uninhabitability.” While tracing longer imperial genealogies, the primary focus is on notions of habitability in relation to European global empires in the nineteenth and twentieth centuries, and their postcolonial legacies. The article traces three key themes in the literature: that habitability was inherently limited, and beyond those limits allegedly lay uninhabitability; that habitability was differential and that certain places were habitable for some groups but not others (but that this might be changed by technological interventions); and finally, that the limits of habitability were not static, but could change for both better and worse. Here the links between colonialism and ideas of acclimatization, terraforming, “improvement,” deliberate uninhabitability, and an “Anthropocene” have all been central to the literature. These have often been closely associated with insidious forms of environmental determinism, which are taking on new forms in an age of crisis (especially in narratives around climate and migration). By drawing together previously disparate literatures, this article ultimately calls on scholars to embrace habitability studies more widely, and to expand on their interdisciplinary potential for communicating the societal consequences of a changing climate.This article is categorized under:
Climate, History, Society, Culture > Ideas and Knowledge
Stringency and timeliness of COVID‐19 policies in managing the pandemic in Queensland: Lessons from 2020
Authors: Vogler Jessica , Tudehope Lucy , Phung Hai , Bernard Natalie Reyes , Sofija Ernesta 
Published: May 2023

AbstractQueensland experienced relatively low case numbers during the first year of the coronavirus disease 2019 (COVID‐19) pandemic. This may be due to timely, stringent policies, yet there is currently no research evaluating this link, despite the state government playing such a primary role in the pandemic response. This ecological study used a cross‐sectional design to examine the stringency and timeliness of Queensland's containment policies and their impact on COVID‐19 cases in 2020. To achieve this, the authors generated a stringency index for Queensland in 2020 in line with the Oxford COVID‐19 Government Response Tracker (OxCGRT) method, since these data were not available at the time. The national context was also provided by examining the relationship between case numbers and policies in Australia. The findings demonstrated a statistically significant relationship between policy stringency and case numbers in both Australia and Queensland. While Australia experienced two waves of COVID‐19 in 2020, Queensland only experienced one. In terms of timeliness, there was a reactive approach to the first wave, with rapid escalation of policy stringency in both Queensland and Australia as a whole. Queensland's ability to prevent a second wave in 2020 may be due to a more systematic, gradual de‐escalation of policies and the maintenance of strategies such as interstate border controls. This study suggests that preventing the reintroduction of new cases after a period of elimination is important. Recommendations are made for the application and interpretation of the stringency index. Further research is needed to understand the relationship between de‐escalation strategies and outcomes.
Atmospheric Carbon Dioxide and Changing Ocean Chemistry
Authors: Schulz Kai G. , Maher Damien T. 
Published: May 2023

Abstract“They call it life, we call it pollution” is an infamous quote which ignores many facts about why carbon dioxide (CO2) poses a significant problem for the ocean. But before we get to this, let’s start at the beginning. All organisms on Earth require a particular set of elements for growth. In the case of plants, these elements are needed to synthesise organic matter in a process called primary production via photosynthesis, and in the case of animals, these elements are directly assimilated by either consuming plant material or by preying on other animals. In this respect, one of the key elements is carbon. Being the molecular backbone for a number of vital organic compounds such as sugars, proteins and nucleic acids (containing genetic information), carbon can be considered as the building block of life.
Marine Contaminants of Emerging Concern
Authors: Mortimer Munro , Batley Graeme 
Published: May 2023

AbstractIdentifying and listing substances or materials as contaminants of emerging concern(CECs) is not a simple task, and for the marine environment specifically is a challenge for environmental regulators, managers and researchers worldwide (Box 13.1) (Tornero V, and Hanke G (2017) Potential chemical contaminants in the marine environment: An overview of main contaminant lists. Office of the European Union Publications, Luxembourg. Available at: http://publications.jrc.ec.europa.eu/repository/bitstream/JRC108964/potential_chemical_contaminants_in_the_marine.pdf [Accessed 19 August2019].). Some of these agencies have widely different definitions of what a CEC actually is (Halden J Hazard Mater 282:2–9, 2015).
Assessing Organism and Community Responses
Authors: Reichelt-Brushett Amanda , Howe Pelli L. , Chariton Anthony A. , Warne Michael St. J. 
Published: May 2023

AbstractMany of the chemicals in the environment are naturally derived from compounds in plants, petroleum oils, or minerals in rocks. However, their chemical composition, concentration, and distribution through the environment have been altered by humans, usually as a result of an economic incentive (e.g., mining).
The Education System in Post-conflict Syria – Examining PIRLS as an International Assessment Measure to Ensure the Quality of Students Achievements
Authors: Ibrahim Yaser Abdulrahman 
Published: May 2023

AbstractThis paper provides a general contextualisation of assessment and learning criteria and processes within the framework of leadership and management perspective in post-conflict and war affected countries, with Syria as an example. Through this paper the researcher provided an overview of the related academic literature done on the subject as well as evaluating the importance of applying one of the International Assessment Measures (IAMs) as a solution for educational reformation. The paper evaluates the adoption of one assessment measure to support the special and emergency requirements of post-conflict countries such as Syria.
The Impact of Macroeconomic Factors on the Nifty Auto Index
Authors: Alexander Rhoda , Al-Malkawi Husam Aldin 
Published: May 2023

AbstractThe aim of the paper is to investigate the association between selected macroeconomic variables like crude price, exchange rate, index of industrial production, inflation, interest rate, repo rate, gold price and the auto index of the National Stock Exchange (NSE) of India during a time when the automotive sector in India witnessed the sharpest dip in sales. The study adopts Autoregressive Distributed Lag (ARDL) co-integration approach and performs suitable diagnostic tests. Results indicate that, exchange rate has a significant negative relationship with Nifty auto index in the long run. Additionally, crude price, index of industrial production and repo rates are statistically significant determinants of Nifty auto index. On the contrary, first lag of crude price is found to be a possible predictor of the index in the short run. The study provides important implications for researchers, corporations, portfolio managers, investors, and government. Despite the availability of a large body of literature exploring the association between macro-economic factors and stock market in India, research exploring the association between the former and Indian auto indices has been sparse. Hence, this study is intended to fill this gap in the literature.
Critical Thinking Skills Profile of High School Students in AP Chemistry Learning
Authors: Raslan Gilan 
Published: May 2023

AbstractFrom classrooms to workplaces, educators and policy makers have emphasized the necessity of graduating students who are strong critical thinkers for nearly 50 years and more (Forawi 2016). Critical thinking skills are a vital pillar skill to tackle the challenges of the twenty-first century.Critical thinking is defined as a set of fundamental skills that must be mastered before one may progress to more complicated thinking. Aiming to obtain more insight into the aspects of critical thinking, the present study particularly examines quantitively the critical thinking skills level of grade 12 students in a scientific learning context. Over a 35-min test, based on Danczak DOT criteria, data was collected and analyzed. The study’s findings revealed that the students’ critical thinking abilities are in medium range. However, other implications regarding curriculum modifications, educational teaching strategies and teachers’ readiness are needed to foster students’ critical thinking skills.
Moving from the Subject-Based Curriculum to the Skills-Based Curriculum in Abu Dhabi Schools: Does It Lead to Reform? A Theoretical Analysis & Case Study Paper in One of Abu Dhabi Private Schools
Authors: Ibrahim Yaser Abdulrahman 
Published: May 2023

AbstractThis paper is a theoretical research study examining the feasibility of implementation of skills-based curriculum model as it relates to the UAE in comparison to other countries. Through this Paper, the researcher made a conceptual analysis, revisited the relevant literature, and identified the theoretical framework of curriculum reform in the UAE educational system with a view on the intended development of curriculum from the conventional subject-based model into the more futuristic and aspiring skills-based in Abu Dhabi schooling environment. The results showed that educational authorities in the UAE should place their focus on an enhanced model of skills-based curriculum, generally known in the literature as the “attained curriculum” category, as an enhanced model of skills-based curriculum to achieve meaningful learning.
Examples Concerning the Main Result
Authors: Cornelissen Gunther , Peyerimhoff Norbert 
Published: May 2023

AbstractWe study whether it is possible to apply twisted Laplace spectra (and, if so, how many are necessary) to deduce isometry of some well-known examples of isospectral manifolds in the literature, due to Schüth (simply connected manifolds), Ikeda (lens spaces), Vignéras/Linowitz and Voight (arithmetic surfaces), Milnor (lattice examples), Doyle and Rossetti (Tetra and Didi), Sunada (based on group-theoretical examples from Gerst, Gaßmann and Komatsu), Brooks and Tse (surfaces of small genus, Riemann surfaces of small genus), Barden and Kang (surfaces of genus two), and Miatello and Rossetti (flat manifolds isospectral for all twists by linear characters).