bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of suspected and known eosinophilic esophagitis—a nationwide survey in Austria
Authors: Schreiner Philipp , Balcar Lorenz , Schlager Hansjörg , Madl Christian , Ziachehabi Alexander , Mader Markus , Steidl Karin , Dinkhauser Patrick , Reider Simon , Dolak Werner , Dejaco Clemens , Gröchenig Hans Peter , Novacek Gottfried 
Published: April 2023

Summary
Introduction
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus with increasing incidence and dysphagia as the main symptom. The management of suspected or known EoE by Austrian endoscopists has not been investigated yet.

Methods
A web-based survey with 13 questions about the management of EoE was sent to endoscopists via the Austrian Society of Gastroenterology and Hepatology (ÖGGH).

Results
A total of 222 endoscopists (74% gastroenterologists, 23% surgeons, and 2% pediatricians; 68% working in a hospital) from all 9 states participated. In patients with dysphagia but a normal appearing esophagus, 85% of respondents reported always taking biopsies; however, surgeons were less likely to obtain biopsies compared to gastroenterologists (“always” 69% vs. 90%, “sometimes” 29% vs. 10%, “never” 2% vs. 0%, p < 0.001). The approved budesonide orodispersible tablet is the preferred first-line drug used in EoE, ahead of proton pump inhibitors (PPI). Only 65% of participants monitor the patients by endoscopy and histology after 12 weeks of induction therapy, 26% do not continue maintenance therapy, and 22% monitor patients only when symptomatic.

Conclusion
The vast majority of Austrian endoscopists adhere to the European and US guidelines in cases of suspected EoE. In contrast, despite the chronic disease course, a significant percentage of providers indicate not to use maintenance therapy and monitor the patients routinely.
Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells
Authors: Ma Junxuan , Häne Surya , Eglauf Janick , Pfannkuche Judith , Soubrier Astrid , Li Zhen , Peroglio Marianna , Hoppe Sven , Benneker Lorin , Lang Gernot , Wangler Sebastian , Alini Mauro , Creemers Laura B. , Grad Sibylle , Häckel Sonja 
Published: April 2023

Abstract
Purpose
This study aims to analyze the effect of pro-inflammatory cytokine-stimulated human annulus fibrosus cells (hAFCs) on the sensitization of dorsal root ganglion (DRG) cells. We further hypothesized that celecoxib (cxb) could inhibit hAFCs-induced DRG sensitization.

Methods
hAFCs from spinal trauma patients were stimulated with TNF-α or IL-1β. Cxb was added on day 2. On day 4, the expression of pro-inflammatory and neurotrophic genes was evaluated using RT-qPCR. Levels of prostaglandin E2 (PGE-2), IL-8, and IL-6 were measured in the conditioned medium (CM) using ELISA. hAFCs CM was then applied to stimulate the DRG cell line (ND7/23) for 6 days. Then, calcium imaging (Fluo4) was performed to evaluate DRG cell sensitization. Both spontaneous and bradykinin-stimulated (0.5 μM) calcium responses were analyzed. The effects on primary bovine DRG cell culture were performed in parallel to the DRG cell line model.

Results
IL-1ß stimulation significantly enhanced the release of PGE-2 in hAFCs CM, while this increase was completely suppressed by 10 µM cxb. hAFCs revealed elevated IL-6 and IL-8 release following TNF-α and IL-1β treatment, though cxb did not alter this. The effect of hAFCs CM on DRG cell sensitization was influenced by adding cxb to hAFCs; both the DRG cell line and primary bovine DRG nociceptors showed a lower sensitivity to bradykinin stimulation.

Conclusion
Cxb can inhibit PGE-2 production in hAFCs in an IL-1β-induced pro-inflammatory in vitro environment. The cxb applied to the hAFCs also reduces the sensitization of DRG nociceptors that are stimulated by the hAFCs CM.
Lipid-based liquid crystalline materials in electrochemical sensing and nanocarrier technology
Authors: Zatloukalova Martina , Poltorak Lukasz , Bilewicz Renata , Vacek Jan 
Published: April 2023

AbstractSome biologically active substances are unstable and poorly soluble in aqueous media, at the same time exhibiting low bioavailability. The incorporation of these biologically active compounds into the structure of a lipid-based lyotropic liquid crystalline phase or nanoparticles can increase or improve their stability and transport properties, subsequent bioavailability, and applicability in general. The aim of this short overview is (1) to clarify the principle of self-assembly of lipidic amphiphilic molecules in an aqueous environment and (2) to present lipidic bicontinuous cubic and hexagonal phases and their current biosensing (with a focus on electrochemical protocols) and biomedical applications.
Graphical Abstract
Identification and sequence determination of a new chrysovirus infecting the phytopathogenic fungus Dothistroma septosporum
Authors: Shah Unnati A. , Daudu John O. , Filippou Charalampos , Tubby Katherine V. , Coutts Robert H. A. , Kotta-Loizou Ioly 
Published: April 2023

AbstractA new double-stranded (ds) RNA mycovirus has been identified in isolate Ds752-1 of the phytopathogenic fungus Dothistroma septosporum, the causal agent of Dothistroma needle blight, also known as red band needle blight or pine needle blight. Dothistroma septosporum chrysovirus 1 (DsCV-1) is a new member of the genus Alphachrysovirus in the family Chrysoviridae. The DsCV-1 genome comprises four dsRNA elements designated 1, 2, 3, and 4 from largest to smallest. dsRNA1 encodes an RNA-dependent RNA polymerase (RdRP) that is most similar to the RdRP of Erysiphe necator associated chrysovirus 3. dsRNA2 potentially encodes two hypothetical proteins, one of which is small and has no homology to known proteins, and one of which is large with significant sequence similarity to the alphachryso-P3 of other alphachrysoviruses. dsRNA3 and dsRNA4 encode a coat protein (CP) and a putative cysteine protease, respectively. This is the first report of a mycovirus infecting the fungus D. septosporum, and DsCV-1 is one of three Chrysoviridae family members found to possess genomic dsRNAs potentially encoding more than one protein.
Development of the gut microbiota in the first 14 years of life and its relations to internalizing and externalizing difficulties and social anxiety during puberty
Authors: Ou Yangwenshan , Belzer Clara , Smidt Hauke , de Weerth Carolina 
Published: April 2023

AbstractRelations between the gut microbiota and host mental health have been suggested by a growing number of case–control and cross-sectional studies, while supporting evidence is limited in large community samples followed during an extended period. Therefore, the current preregistered study (https://osf.io/8ymav, September 7, 2022) described child gut microbiota development in the first 14 years of life and explored its relations to internalizing and externalizing difficulties and social anxiety in puberty, a period of high relevance for the development of mental health problems. Fecal microbiota composition was analysed by 16S ribosomal RNA gene amplicon sequencing in a total of 1003 samples from 193 children. Through a clustering method, four distinct microbial clusters were newly identified in puberty. Most children within three of these clusters remained in the same clusters from the age of 12 to 14 years, suggesting stability in microbial development and transition during this period. These three clusters were compositionally similar to enterotypes (i.e., a robust classification of the gut microbiota based on its composition across different populations) enriched in Bacteroides, Prevotella, and Ruminococcus, respectively. Two Prevotella 9-predominated clusters, including one reported by us earlier in middle childhood and the other one in puberty, were associated with more externalizing behavior at age 14. One Faecalibacterium-depleted pubertal cluster was related to more social anxiety at age 14. This finding was confirmed by a negative cross-sectional relation between Faecalibacterium and social anxiety in the 14-year-olds. The findings of this study continue to map gut microbiota development in a relatively large community sample followed from birth onwards, importantly extending our knowledge to puberty. Results indicate that Prevotella 9 and Faecalibacterium may be relevant microbial taxa in relation to externalizing behavior and social anxiety, respectively. These correlational findings need validations from other similar cohort studies, as well as well-designed mechanistic pre-clinical investigations before inferring cause and effect.
Economic development through women’s economic rights: a panel data analysis
Authors: Naveed Amjad , Ahmad Nisar , Naz Amber , Zhuparova Aziza 
Published: April 2023

AbstractIncreasing gender equality and enhancing women empowerment through work opportunities are the important steps in achieving sustainable development. The aim of this paper is threefold: (1) to empirically examine the relationship between women economic rights and economic growth for the global sample. (2) To explore whether the effect of women’s economic rights is different across different economies. (3) This paper uses spatial econometric techniques to examine the impact of women’s economic rights on neighbouring countries. For empirical purpose, we use the data for 171 countries over the period 1960–2016. The results show that women’s economic rights positively affect growth; however, the effect is heterogeneous across different economies. From spatial analysis, we confirm that 75% spillover effect of women economic rights is passing through neighbouring country. The results of this study are consistent and coherent with the EU policy about women’s economic empowerment where it claims that joint effort in promoting women empowerment by all actors could lead to sustainable development and growth.
Factors affecting policy implementation for childhood obesity prevention in New South Wales, Australia: policy mapping and interviews with senior officials
Authors: Esdaile Emma K. , Henderson Suzanna B. , Wen Li Ming , Baur Louise A. , Rissel Chris 
Published: April 2023

Abstract
Aim
To explore the implementation of a whole-of-government strategy as a policy tool for the early prevention of childhood obesity in New South Wales (NSW), Australia.

Subject and methods
This paper presents a case study of childhood obesity prevention in the context of implementing the NSW Healthy Eating and Active Living (HEAL) Strategy. We undertook reflexive thematic analysis of interviews with senior officials (n = 25) and content analysis of policy mapping across the NSW Government.

Results
HEAL was dominated by approaches focused on health services and settings and few environmental actions were undertaken. Four themes were identified: (1) making good citizens, (2) narrowing the scope of prevention, (3) competing government interests and (4) limited collaborative mechanisms. We additionally identified a cross-cutting theme around the expressed need for more evidence.

Conclusion
Ultimately the HEAL Strategy provided a comprehensive framework with the potential to prevent obesity in early childhood, but it lacked commitment from leadership and willingness across agencies to ensure collaboration on its most contentious areas, notably food environments.
‘The internet is in the satellites!’: A systematic review of 3–15-year-olds’ conceptions about the internet
Authors: Brom Cyril , Yaghobová Anna , Drobná Anna , Urban Marek 
Published: April 2023

AbstractChildren aged 3–15 frequently use internet-enabled technologies for leisure and educational purposes, yet they have limited knowledge about how the internet works. Literature also indicates that children possess varied and often contradictory internet-related ideas, which have not yet been systematized. This systematic review, drawing from 27 mixed-methods and qualitative studies (N = 2,214) from the last two decades (2002 – 2022), organizes these ideas through a thematic analysis with a specific focus on the age when individual child conceptions start to appear at the earliest. The findings are interpreted through the lenses of a Vygotskian framework. The results highlight 60 conceptions concerning general perceptions of the internet, internet infrastructure, and dataflow. Children appear to understand the internet primarily through their personal experiences. Perception of the internet as online activities is dominant in younger children, but also present among older ones. Children in all age groups are confused about what Wi-Fi really is; some equate it to the internet, others to the ‘Wi-Fi box’ (Wi-Fi router). The most knowledgeable older children view the internet as a global network with a complex internal, but only vaguely understood, structure. Typical reasoning among older children about the internet’s structure includes satellites, central computers or central towers. Only expert children know about distributed, server-like storage. These results imply that children at the K-8 level need to be familiarized gradually with how the internet works, but teaching them this topic may prove to be challenging. This review also highlights the limitations of existing literature and presents suggestions for future research and designing technology-based curricula.
Peer Victimization: an Integrative Review and Cross-National Test of a Tripartite Model
Authors: Marsh Herbert W. , Guo Jiesi , Parker Philip D. , Pekrun Reinhard , Basarkod Geetanjali , Dicke Theresa , Parada Roberto H. , Reeve Johnmarshall , Craven Rhonda , Ciarrochi Joseph , Sahdra Baljinder , Devine Emma K. 
Published: April 2023

AbstractSchool victimization issues remain largely unresolved due to over-reliance on unidimensional conceptions of victimization and data from a few developed OECD countries. Thus, support for cross-national generalizability over multiple victimization components (relational, verbal, and physical) is weak. Our substantive–methodological synergy tests the cross-national generalizability of a three-component model (594,196 fifteen-year-olds; nationally -representative samples from 77 countries) compared to competing (unidimensional and two-component) victimization models. We demonstrate the superior explanatory power of the three-component model—goodness-of-fit, component differentiation, and discriminant validity of the three components concerning gender differences, paradoxical anti-bullying attitudes (the Pro-Bully Paradox) whereby victims ﻿are more supportive of bullies than of other victims, and multiple indicators of well-being. For example, gender differences varied significantly across the three components, and all 13 well-being indicators were more strongly related to verbal and particularly relational victimization than physical victimization. Collapsing the three components into one or two components undermined discriminant validity. Cross-nationally, systematic differences emerged across the three victimization components regarding country-level means, gender differences, national development, and cultural values. These findings across countries support a tripartite model in which the three components of victimization—relational, verbal, and physical—relate differently to key outcomes. Thus, these findings advance victimization theory and have implications for policy, practice, and intervention. We also discuss directions for further research: the need for simultaneous evaluation of multiple, parallel components of victimization and bullying, theoretical definitions of bullying and victimization and their implications for measurement, conceptual bases of global victimization indices, cyberbullying, anti-bullying policies, and capitalizing on anti-bullying attitudes.
Fast and reliable voltammetric determination of menaquinone (vitamin K2) produced in vitro by Bacillus subtilis cultures
Authors: Smajdor Joanna , Porada Radosław , Lipińska Justyna , Więcek Grażyna , Jedlińska Katarzyna , Baś Bogusław , Strus Magdalena 
Published: April 2023

AbstractVitamin K2 (VK2) is one of two natural forms of vitamin K, necessary for the proper functioning of organisms. Currently, it is sourced from chemical synthesis, nonetheless, it is worth reaching out to its natural sources. The aim of the study was to devise a voltammetric procedure for the determination of vitamin K2 (VK2) produced by bacteria in order to find the strain that exhibits the highest efficiency of VK2 production. Bacillus subtilis, isolated from traditional Japanese food (Nattō), was chosen as a model strain. Employment of the Controlled Growth Mercury Drop Electrode (CGMDE) was crucial, as it is the only electrode that allows performing the measurement on the surface specifically renewed directly before, thus minimizing the influence of interferents. This new method was successfully applied for VK2 determination in supernatant samples. Developed procedure is robust and easily adjustable for the variety of biological matrixes. Strong differences in VK2 production depending on cultivation time were observed, but no direct correlation between the VK2 concentration in the breeding medium and the cultivation time was found. The devised protocol will be used in further measurements with different bacteria species that have the ability to produce VK2 and settle in the human intestine.
Graphical abstract
The Change of Practitioner’s Self-Efficacy in Triple P Professional Training: Moderating Role of Practitioner Characteristics, Country, and Delivery Mode
Authors: Sanders Matthew R. , Hoang Nam-Phuong T. , Gerrish Ruby J. , Ralph Alan , McWilliam Jenna 
Published: April 2023

AbstractTwo studies examined the change in self-efficacy of practitioners after attending Triple P training and the moderators that affect training outcomes. Study 1 used a large multidisciplinary sample of health, education, and welfare practitioners (N = 37,235) came from 30 countries around the world, which all participate in a Triple P professional training course during 2012–2019. This study assessed practitioners’ overall self-efficacy and their consultation skills efficacy prior to training, immediately following training, and at six- to eight-weeks follow-up. Participants reported significant improvements of their overall self-efficacy and their consultation skills self-efficacy. There were significantly small differences based on practitioners’ gender, disciplines, education levels, and country location. Study 2 examined the training outcomes of videoconference-based training (following the COVID-19 pandemic) compared to in-person training (N = 6867). No significant differences were found between videoconference and in-person training on any outcome measure. Implications for the global dissemination of evidence-based parenting programs as part of a comprehensive public health response to COVID-19 was discussed.
Radiation Synthesis of Edible Coating Films of Nanocurcumin Based on Carboxymethyl Chitosan/Polyvinyl Alcohol to Extend the Shelf Life of Sweet Orange "Valencia"
Authors: Elbarbary Ahmed M. , Khozemy Ehab E. , El-Dein Asmaa Ezz , El-Sawy Naeem M. 
Published: April 2023

AbstractEdible coating CMCS/PVA/Cur and films were prepared using γ-irradiation to extend the shelf-life of sweet orange "Valencia" fruits. Water-soluble CMCS was synthesized by carboxymethylation of chitosan. Extraction of curcumin from turmeric powder and conversion to Cur-NPs of 76–108 nm average size was achieved. CMCS/PVA/Cur membranes were prepared via the casting method and gamma-irradiation technique. The chemical properties were studied by FTIR and XRD as well as studying the effect of irradiation dose on gel content, water swelling, and mechanical properties. FTIR and XRD results confirm the interaction between functional groups of Cur-NPs with CMCS/PVA polymer chains. Results indicated that the membrane possessed good tensile strength and gel content of 97.4% and the swelling was significantly decreased with increasing the irradiation dose. Fruits were dipped in CMCS/PVA/Cur coatings at different concentrations of Cur-NPs (0, 2.5, 5, and 10%) and stored at room temperature of 65–70% RH for about 70 days. The efficiency of coatings was assessed by decay (%), weight loss (%), pH, vitamin C content, total soluble solids (TSS), titratable acidity (TA), and TSS/TA ratio. Quality characteristics of coated fruits were better than uncoated fruits especially the coating solution of 2.5% Cur-NPs provides accepted freshness and quality. No decay was noticed for the coated fruits till 56 days, whereas the control exhibited decay of 36%. The prepared coating solutions possessed good antimicrobial activity and cytocompatibility characteristics and showed normal viability even at all concentrations. Results demonstrated a promising packaging material to extend the shelf life and freshness of orange fruits.
Constraint-based adaptive robust tracking control of uncertain articulating crane guaranteeing desired dynamic control performance
Authors: Zhang Zheshuo , Zhang Bangji , Yin Hui 
Published: April 2023

AbstractArticulating crane (AC), a widely used crane, plays an essential role in various industrial activities. Owing to its strong nonlinearity and uncertainty, its tracking control remains challenging, particularly for precise dynamic tracking control. This paper proposes an adaptive diffeomorphism-constraint-based control (ADCBC) for a nonlinear AC to robustly achieve trajectory tracking while guaranteeing desired dynamic control performance (DDCP), considering (possibly rapid and irregular) time-variant uncertainty with unknown bounds. A user-definable hard-limiting function was used to guarantee the DDCP, including the requirement for steady-state tracking error and dynamic convergence speed. The desired trajectories and DDCP were formulated as equality and inequality servo constraints, respectively. A diffeomorphism approach was adopted to incorporate inequality servo constraints into equality servo constraints, yielding new equality servo constraints. Thus, the control task was converted to enable the transformed AC to follow the new equality servo constraints and was completed by a constraint-based control (CBC) scheme, where an adaptive law was established for the estimation of online uncertainty bounds to compensate for uncertainty. No approximations or linearizations were invoked. The effectiveness and robustness of the proposed ADCBC were confirmed through rigorous proofs and simulation results. To the best of our knowledge, this is the first endeavor in tracking control while guaranteeing the DDCP for uncertain AC-like systems.