bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient disclosure of medical errors in paediatrics: A systematic literature review
Authors: Koller Donna , Rummens J Anneke , Le Pouesard Morgane , Espin Sherry , Friedman Jeremy , Coffey Maitreya , Kenneally Noah 
Published: May 2023

<p>Medical errors are common within paediatrics; however, little research has examined the process of disclosing medical errors in paediatric settings. The present systematic review of current research and policy initiatives examined evidence regarding the disclosure of medical errors involving paediatric patients. Peer-reviewed research from a range of scientific journals from the past 10 years is presented, and an overview of Canadian and international policies regarding disclosure in paediatric settings are provided. The purpose of the present review was to scope the existing literature and policy, and to synthesize findings into an integrated and accessible report. Future research priorities and policy implications are then identified. </p>
Analisis Kemampuan Representasi Matematis Siswa Ditinjau dari Motivasi Belajar
Authors: Tamonob Papi Y , Bien Yusak I , Abi Alfonsa M 
Published: May 2023

Penelitian dilakukan di SMP Negeri 2 Amanuban Tengah dengan subjek adalah siswa kelas VII sebanyak 13 siswa. Penelitian ini menggunakan pendekatan kualitatif dengan teknik pengumpulan data berupa tes, angket dan wawancara. Teknik analisis data menggunakan model Miles dan Huberman. Hasil penelitian menunjukkan bahwa siswa bermotivasi tinggi, dari keempat indikator representasi matematika sudah mampu pada indikator menyajikan kembali data atau informasi dari suatu representasi ke representasi tabel tapi tidak pada tiga indikator representasi matematika lainnya. Siswa bermotivasi tinggi lainnya juga sudah mampu pada indikator menyajikan kembali data atau informasi dari suatu representasi ke representasi tabel namun kurang mampu pada tiga indikator lainnya sedangkan siswa dengan motivasi belajar sedang mampu menyelesaikan keempat indikator dengan baik. Siswa dengan motivasi belajar sedang lainnya juga sudah mampu menyelesaikan indikator menyajikan kembali data atau informasi dari suatu representasi ke representasi tabel, kurang mampu pada dua indikator dan tidak mampu menyelesaikan masalah dengan melibatkan ekspresi matematika. Hasil penelitian ini menunjukkan bahwa siswa bermotivasi belajar tinggi belum tentu memiliki representasi matematika yang tinggi dan siswa yang memiliki motivasi belajar sedang belum tentu memiliki representasi matematika yang rendah.
Analisis Faktor-Faktor Yang Mempengaruhi Keaktifan Siswa Kelas VIII-1 SMPN 11 Tanjungpinang Dalam Pembelajaran Matematika
Authors: Br Peranginangin Amoria Mahdalena , Izzati Nur 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi keaktifan siswa kelas VIII-1 SMPN 11 Tanjungpinang dalam pembelajaran matematika. Penelitian ini merupakan penelitian kualitatif dengan jenis penelitian deskriptif. Subjek yang digunakan dalam penelitian ini adalah siswa/i kelas VIII-1. Metode yang digunakan untuk pengumpulan data penelitian adalah angket dan wawancara guru serta siswa. Teknik analisis yang digunakan adalah reduksi data, penyajian data dan penarikan kesimpulan. Untuk keabsahan data menggunakan triangulasi teknik. Hasil penelitian ini menunjukkan bahwa faktor-faktor yang mempengaruhi keaktifan siswa kelas VIII-1 SMPN 11 Tanjungpinang dalam pembelajaran matematika adalah faktor internal dan eksternal. Faktor internal seperti faktor fisiologis yaitu fungsi jasmani dan faktor psikologis yaitu perhatian, tanggapan, motivasi dan minat serta faktor eksternal seperti faktor lingkungan non-sosial yaitu tempat dan fasilitas belajar dan faktor lingkungan sosial yaitu guru dan keluarga merupakan faktor yang mendukung keaktifan keaktifan siswa kelas VIII-1 dalam pembelajara matematika. Sedangkan, faktor internal seperti faktor fisiologis yaitu keadaan jasmani dan faktor psikologis yaitu ingatan serta faktor eksternal seperti lingkungan non-sosial yaitu suasana belajar dan faktor lingkungan sosial yaitu teman merupakan faktor yang menghambat keaktifan siswa kelas VIII-1 dalam pembelajaran matematika. Faktor yang dominan mempengaruhi keaktifan siswa kelas VIII-1 dalam pembelajaran matematika adalah faktor psikologi siswa.
Analisis Kemampuan Berpikir Komputasional Matematis Siswa Pada Materi Program Linear
Authors: Lestari Siska , Roesdiana Lessa 
Published: May 2023

Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis kemampuan berpikir komputasi matematis siswa pada materi program liniear. Jenis penelitian yang digunakan pada penelitian ini yaitu penelitian deskriptif kualitatif. Populasi penelitian ini merupakan seluruh siswa kelas XI SMA Negeri 1 Cikampek yang terdaftar pada semester gasal tahun ajaran 2022/2023. Subjek penelitian yang digunakan oleh peneliti diambil menggunakan teknik Sampling Kuota dengan jumlah kuota yang diinginkan sebanyak 35 siswa pada kelas XI. Pengumpulan data yang dslakukan dengan tes dalam bentuk soal uraian sebanyak 1 butir soal yang keseluruhan mencangkup indikator kemampuan berpikir kompuatasi matematis yaitu dekomposisi, pengenalan pola, abstraksi, dan berpikir alogaritma. Dari hasil analisis yang diperoleh nilai rata-rata dari 35 siswa sebesar 67,39 dengan nilai minimum sebesar 37,50 dan nilai maksimum sebesar 100. Kemampuan berpikir komputasional siswa dapat dikategorikan menjadi 5 kategori yaitu : pada kategori sangat baik terdapat 3 siswa dengan presentase 8%, kategori baik terdapat 6 siswa dengan presentase 17%, kategori cukup terdapat 15 siswa dengan presentase 43%, kategori rendah terdapat 9 siswa dengan presentase 26%, dan pada kategori sangat rendah terdapat 2 siswa dengan presentase 6%. Dapat disimpulkan bahwa siswa pada kategori baik sudah mampu memenuhi semua indikator namun kurang sempurna pada indikator berpikir abstraksi.
Determinants of Intrapartum Still Birth and Early Neonatal Death in a Periurban Hospital
Authors: Tasnim Saria , Parvin Rubaiyat , Afrin Tahmina , Nazmeen Summyia 
Published: May 2023

Stillbirth and early neonatal death is quite high in Bangladesh. The current study was undertaken to find out sociodemographic and pregnancy related risk factors that may exist with cases of stillbirth and death during first 7 days of life. This was a cross sectional study conducted at Institute of Child and mother health (ICMH) between February to June 2015. Mothers delivered still birth baby at ICMH and whose babies were admitted in neonatal ward immediately after birth for delay to cry were enrolled consecutively. Data was collected by interviewing mothers and reviewing hospital records using structured questionnaire. Follow up was done till 7 days. Data analysis was done with SPSS version 14 Among a total 116 mothers 83.6% came from rural areas, 48.2% belong to 20-25 years age group with mean age 23±5 year, 46.6% had primary education, 89.7% were primipara, and 62.9% had more than 4 antenatal visits in index pregnancy. Common pregnancy related problems were anaemia (85.3%), preeclampsia (41.4%), less fetal movement (31.9%), polyhydramnios (13.8%), oligohydramnios (12.9%), premature rupture membrane (58.6%), prolong labour 48.3%), malpresentation (8.6%) and urinary tract infection in 12.1%. About 69.8% delivered at hospital, 59% had normal vaginal delivery, instrumental delivery 17.2% and caesarean section in 24.1%. About 57.8% babies were born preterm. and 55.1% were low birth weight. During first 7 days of life 32% developed neonatal sepsis and 32.8% died. Cause of death as recorded was perinatal asphyxia (55.17%), hypoxic ischemic encephalopathy 17.2%, low birth weight with perinatal asphyxia in 35.6% and meconium aspiration syndrome 4.5%. Stillbirth and early neonatal deaths are obstetric catastrophe and has common overlapping risk factors. Risk specific interventions with special emphasis on improvement of quality of care throughout the phases of pregnancy, delivery and postpartum period is recommended
Bangladesh J Obstet Gynaecol, 2021; Vol. 36(1): 10-17
Obstetric Concern, Management and Considerations in the Context of COVID-19 Pandemic
Authors: Haque Nadira , Hosain Nazmul , Ara Gulshan , Nasrin Begum , Fatema Nargis , Dorjey Yeshey 
Published: May 2023

Coronavirus disease (COVID-19) has emerged as a global threat. The disease largely attacks adults with higher mortality among the aged and compromised people. Although previous coronavirus havocs caused significant number of maternal and neonatal demise, most pregnant cases with COVID-19 infection are either asymptomatic or with mild symptoms only. This pandemic brought significant disruption of essential antenatal and intranatal care worldwide. The health resources became diverted to focus on general population needs rather than the specified needs of pregnant women. Limited information is known about the effect of COVID-19 disease on pregnancy. Recent evidence indicates that pregnant women are not vulnerable group for severe COVID-19 illness. However, immunological and physiological alterations during pregnancy expose women more vulnerable to SARS-CoV- 2 infection in comparison to general population.Covid-19 pandemic has created a global crisis causing great challenges for pregnant women and their obstetricians. Although the due course of pregnancy is not strained by the disease itself but complications can happen in absence of proper care and caution. Both the pregnant mother and care-giver should be vigilant and the obstetric management should be implemented following evidence based standard protocol.
Bangladesh J Obstet Gynaecol, 2021; Vol. 36(1): 49-56
Nonsurgical Management of Mullerian Agenesis with Saline Injection and Sustained Digital Pressure: A Case Series
Authors: Ishrat Shakeela , Deeba Farzana , Anwary Shaheen Ara , Banu Jesmine , Fatima Parveen 
Published: May 2023

When a woman with mullerian agenesis presents with blind or absent vagina, management options include surgical vaginoplasty or non surgical self dilatation. Vaginal dilation should be the first line management of mullerian agenesis. Because of the need for motivated, mature patients and long term dilatation and follow up, gynecologists usually go for surgical vaginoplasty. We tried a novel approach to nonsurgical dilation of vagina in the cases of mullerian agenesis. We injected normal saline into the potential space of vagina between urethra and rectum and applied digital pressure daily for 14-15 days. This procedure created a vaginal space which was to be further dilated by regular coitus and/ or vaginal dilators. We are presenting here a series of three cases of mullerian agenesis managed by non surgical vaginal dilatation, facilitated by prior saline injection and sustained digital pressure.
Bangladesh J Obstet Gynaecol, 2021; Vol. 36(1): 65-68
DETERMINATION OF OCCUPATIONAL COMPUTER USAGE LEVELS OF NURSES IN MEDICAL INSTITUTIONS: A REAL HOSPITAL CASE STUDY
Authors: PARLAKKILIÇ Alaattin 
Published: May 2023

With the development of technology, the role and responsibility of
nurses in various health institutions have diversified. The main purpose of
this change is to provide better quality health services to individuals. This
research aims to investigate Information Technology Readiness of Public Health
Nurses in Turkey. A survey was done with a
total of 104 nurses. To measure IT readiness, technological skills readiness,
attitude readiness, task-ready information technology readiness and
institutional support readiness were evaluated using a five-point Likert scale.
The scores of the participants were evaluated as technological skills readiness
was 3.83 (76,6 %); attitude readiness was 3.67 (73,4 %), task-ready information
technology readiness was 3.85 (77%) and institutional support readiness was
3.65 (73 %). The results of the dimensions show that nurses are extremely prone
to use technology in their work. The overall results show that the information
technology readiness for nurses has been found at 3.75 (75 %) and needs a few improvements.
Pandemi Döneminde Üniversite Öğrencilerinin Anksiyete Düzeyi ile Sigara ve Sosyal Medya Kullanım Alışkanlıkları Arasındaki İlişki
Authors: TUĞTAĞ DEMİR Berin , KOCAAY Funda , ALTINTAŞ Hilal Melis 
Published: May 2023

Amaç: Bu araştırma, COVID-19 Pandemisinin sağlık alanındaki üniversite öğrencileri üzerindeki etkisini belirleyerek, öğrencilerin COVID-19 pademisi karşısında yaşadıkları anksiyete ile sigara ve sosyal medya kullanım alışkanlıklar arasındaki değişimi incelemek amacı ile yapılmıştır.
Gereç ve Yöntemler: Kesitsel araştırma yöntemi ile yapılan bu çalışma, 2022-2023 eğitim-öğretim yılı bahar döneminde Ankara Medipol Üniversitesi Tıp, Diş ve Sağlık Bilimleri fakültesinde öğrenim gören 300 kadın 251erkek öğrenci üzerinde yapıldı. Araştırmada Beck anksiyete ölçeği, Koronavirüs Anksiyete Ölçeği, Fagerström Nikotin Bağımlılık Testi (FNBT) ile Sosyal Medya Bağımlılık Ölçeği kullanıldı.
Bulgular: Araştırmada öğrencilerin %18,1’i pandemi öncesinde sigara kullanırken pandemi sonrasında (şu an) %28,1’e çıktığı, %72,4’nün sigaranın COVID-19 riskini arttırdığını düşündükleri ve %76’ sının günde 4-6 saat sosyal medya kullandıkları belirlenmiştir. Tıp fakültesi öğrencilerinin anksiyetelerinin daha fazla olduğu ancak sağlık bilimleri fakültesindeki öğrencilerin hem nikotin bağımlılık puanlarının hem de sosyal medya bağımlılıklarının daha yüksek olduğu tespit edilmiştir (p
Zinc finger and SCAN domain-containing protein 18 is a potential DNA methylation-modified tumor suppressor and biomarker in breast cancer
Authors: Wang Yu , Luo Yuhao , Fu Shaozhi , He Lijia , Pan Guangrui , Fan Dongmei , Wen Qinglian , Fan Yu 
Published: May 2023

IntroductionZinc finger and SCAN domain-containing protein 18 (ZSCAN18) has been investigated as a putative biomarker of multiple human cancers. However, the expression profile, epigenetic modification, prognostic value, transcription regulation, and molecular mechanism of ZSCAN18 in breast cancer (BC) remain unknown.MethodsIn the study, we present an integrated analysis of ZSCAN18 in BC based on public omics datasets with the use of multiple bioinformatics tools. Genes potentially regulated through restoration of ZSCAN18 expression in MDA-MB-231 cells were investigated to identify pathways associated with BC.ResultsWe observed that ZSCAN18 was downregulated in BC and mRNA expression was significantly correlated with clinicopathological parameters. Low expression of ZSCAN18 was found in the HER2-positive and TNBC subtypes. High expression of ZSCAN18 was associated with good prognosis. As compared to normal tissues, the extent of ZSCAN18 DNA methylation was greater with fewer genetic alterations in BC tissues. ZSCAN18 was identified as a transcription factor that might be involved in intracellular molecular and metabolic processes. Low ZSCAN18 expression was associated with the cell cycle and glycolysis signaling pathway. Overexpression of ZSCAN18 inhibited mRNA expression of genes associated with the Wnt/β-catenin and glycolysis signaling pathways, including CTNNB1, BCL9, TSC1, and PFKP. ZSCAN18 expression was negatively correlated with infiltrating B cells and dendritic cells (DCs), as determined by the TIMER web server and reference to the TISIDB. ZSCAN18 DNA methylation was positively correlated with activated B cells, activated CD8+ and CD4+ T cells, macrophages, neutrophils, and activated DCs. Moreover, five ZSCAN18-related hub genes (KDM6B, KAT6A, KMT2D, KDM1A, and HSPBP1) were identified. ZSCAN18, ZNF396, and PGBD1 were identified as components of a physical complex.ConclusionZSCAN18 is a potential tumor suppressor in BC, as expression is modified by DNA methylation and associated with patient survival. In addition, ZSCAN18 plays important roles in transcription regulation, the glycolysis signaling pathway, and the tumor immune microenvironment.
The feasibility of discriminating BRONJ lesion bone with Raman spectroscopy
Authors: Xia Chengwan , Pu Yumei , Zhang Qian , Hu Qingang , Wang Yuxin 
Published: May 2023

BackgroundWith the frequent use of Bisphosphonates (BPs), the morbidity of BP-related osteonecrosis of the jaw (BRONJ) is also increasing. However, the prevention and treatment of BRONJ is faced with enormous challenges. This study aimed to illuminate the influence of BP administration in the rat mandible and explore the feasibility of discriminating BRONJ lesion bone with Raman spectroscopy.Materials and methodsFirst, we explored the time- and mode-dependent effects of BP administration on the rat mandible with Raman spectroscopy. Second, the BRONJ rat model was constructed, and the lesion and healthy bone components were analyzed using Raman spectroscopy.ResultsWhen only BPs were administered, no rats showed BRONJ symptoms, and no difference could be found in the Raman spectra. However, when combined with local surgery, six (6/8) rats showed BRONJ symptoms. The Raman spectra also showed a significant difference between the lesion and healthy bone.ConclusionIn the progression of BRONJ, BPs and local stimulation play an essential role. Both BPs administration and local stimulation need to be controlled to prevent BRONJ. Moreover, BRONJ lesion bone in rats could be discriminated with Raman spectroscopy. This novel method would become a complement in the treatment of BRONJ in the future.
The genetics of autism and steroid-related traits in prenatal and postnatal life
Authors: Tsompanidis Alex , Warrier Varun , Baron-Cohen Simon 
Published: May 2023

BackgroundAutism likelihood is a largely heritable trait. Autism prevalence has a skewed sex ratio, with males being diagnosed more often than females. Steroid hormones play a mediating role in this, as indicated by studies of both prenatal biology and postnatal medical conditions in autistic men and women. It is currently unclear if the genetics of steroid regulation or production interact with the genetic liability for autism.MethodsTo address this, two studies were conducted using publicly available datasets, which focused respectively on rare genetic variants linked to autism and neurodevelopmental conditions (study 1) and common genetic variants (study 2) for autism. In Study 1 an enrichment analysis was conducted, between autism-related genes (SFARI database) and genes that are differentially expressed (FDR&lt;0.1) between male and female placentas, in 1st trimester chorionic villi samples of viable pregnancies (n=39). In Study 2 summary statistics of genome wide association studies (GWAS) were used to investigate the genetic correlation between autism and bioactive testosterone, estradiol and postnatal PlGF levels, as well as steroid-related conditions such as polycystic ovaries syndrome (PCOS), age of menarche, and androgenic alopecia. Genetic correlation was calculated based on LD Score regression and results were corrected for multiple testing with FDR.ResultsIn Study 1, there was significant enrichment of X-linked autism genes in male-biased placental genes, independently of gene length (n=5 genes, p&lt;0.001). In Study 2, common genetic variance associated with autism did not correlate to the genetics for the postnatal levels of testosterone, estradiol or PlGF, but was associated with the genotypes associated with early age of menarche in females (b=-0.109, FDR-q=0.004) and protection from androgenic alopecia for males (b=-0.135, FDR-q=0.007).ConclusionThe rare genetic variants associated with autism appear to interact with placental sex differences, while the common genetic variants associated with autism appear to be involved in the regulation of steroid-related traits. These lines of evidence indicate that the likelihood for autism is partly linked to factors mediating physiological sex differences throughout development.
Increased meso-striatal connectivity mediates trait impulsivity in FTO variant carriers
Authors: Edwin Thanarajah Sharmili , Hanssen Ruth , Melzer Corina , Tittgemeyer Marc 
Published: May 2023

ObjectiveWhile variations in the first intron of the fat mass and obesity-associated gene (FTO, rs9939609 T/A variant) have long been identified as a major contributor to polygenic obesity, the mechanisms underlying weight gain in risk allele carriers still remain elusive. On a behavioral level, FTO variants have been robustly linked to trait impulsivity. The regulation of dopaminergic signaling in the meso-striatal neurocircuitry by these FTO variants might represent one mechanism for this behavioral alteration. Notably, recent evidence indicates that variants of FTO also modulate several genes involved in cell proliferation and neuronal development. Hence, FTO polymorphisms might establish a predisposition to heightened trait impulsivity during neurodevelopment by altering structural meso-striatal connectivity. We here explored whether the greater impulsivity of FTO variant carriers was mediated by structural differences in the connectivity between the dopaminergic midbrain and the ventral striatum.MethodsEighty-seven healthy normal-weight volunteers participated in the study; 42 FTO risk allele carriers (rs9939609 T/A variant, FTO+ group: AT, AA) and 39 non-carriers (FTO− group: TT) were matched for age, sex and body mass index (BMI). Trait impulsivity was assessed via the Barratt Impulsiveness Scale (BIS-11) and structural connectivity between the ventral tegmental area/substantia nigra (VTA/SN) and the nucleus accumbens (NAc) was measured via diffusion weighted MRI and probabilistic tractography.ResultsWe found that FTO risk allele carriers compared to non-carriers, demonstrated greater motor impulsivity (p = 0.04) and increased structural connectivity between VTA/SN and the NAc (p&lt; 0.05). Increased connectivity partially mediated the effect of FTO genetic status on motor impulsivity.ConclusionWe report altered structural connectivity as one mechanism by which FTO variants contribute to increased impulsivity, indicating that FTO variants may exert their effect on obesity-promoting behavioral traits at least partially through neuroplastic alterations in humans.