bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of a blend of Pistacia atlantica seed and canola oil compared with a blend of corn-canola oil with synthetic antioxidant and corn-canola oil without synthetic antioxidant on oxidative stress markers in patients with metabolic syndrome: protocol for a triple-blind, randomized, three-way cross-over clinical trial
Authors: Sasanfar Bahareh , Emrani Arezoo sadat , Zademohammadi Faezeh , Forootani Bita , Emamgholipour Solaleh , Jambarsang Sara , Khayyatzadeh Sayyed Saeid , Pourrajab Fatemeh , Yasini Ardakani Seyed Ali , Esmaillzadeh Ahmad , Salehi-Abarghouei Amin 
Published: July 2023

Abstract
Background
Metabolic syndrome (MetS) is regarded as a complex metabolic disorder. Recently, the role of dietary antioxidants in the underlying pathogenesis and complications of MetS has come into focus. Pistacia atlantica oil is known as a high antioxidant oil which might improve the antioxidant status of dietary oils and also oxidative stress markers. On the other hand, tert-Butylhydroquinone (TBHQ) is an approved food-grade synthetic antioxidant that acts both as an inducer and inhibitor of carcinogenesis. The current trial will explore the possible effect of a blend of Pistacia atlantica seed-canola oils, corn-canola oils with TBHQ, and corn-canola oil without TBHQ on oxidative stress markers in patients with MetS.

Methods
We will conduct a single-center, triple-blind, three-way randomized cross-over clinical trial (RCT) among 72 patients with MetS. After a 1-month run-in period, eligible participants will consume the intervention oils as their regularly consumed oils in a random order. Each intervention period will last 8 weeks separated by 4-week washout periods. Anthropometric indices, body composition, physical activity, blood pressure, and 24-h dietary food recall measurements will be assessed at the beginning and the end of each intervention period. The primary outcome will be oxidative stress markers including serum total antioxidant capacity, total oxidant status, malondialdehyde, nitric oxide, and the enzyme activity of myeloperoxidase, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase. The secondary outcomes will be changes in MetS components including blood pressure, fasting blood glucose, triglyceride, high-density lipoprotein cholesterol, and anthropometric measurements.

Discussion
Pistacia atlantica seed oil is high in antioxidants. An intervention with this oil could offer an option for oxidative stress prevention among patients with metabolic syndrome. The present clinical trial will be the first one assessing the impact of Pistacia atlantica oil on human oxidative stress markers.

Trial registration
Iranian Registry of Clinical trials IRCT20130223012571N8. Registered on 4 March 2022.
The statistical analysis plan for the unification of treatments and interventions for tinnitus patients randomized clinical trial (UNITI-RCT)
Authors: Simoes Jorge Piano , Schoisswohl Stefan , Schlee Winfried , Basso Laura , Bernal-Robledano Alberto , Boecking Benjamin , Cima Rilana , Denys Sam , Engelke Milena , Escalera-Balsera Alba , Gallego-Martinez Alvaro , Gallus Silvano , Kikidis Dimitris , López-Escámez Jose A. , Marcrum Steven C. , Markatos Nikolaos , Martin-Lagos Juan , Martinez-Martinez Marta , Mazurek Birgit , Vassou Evgenia , Jarach Carlotta Micaela , Mueller-Locatelli Nicolas , Neff Patrick , Niemann Uli , Omar Hafez Kader , Puga Clara , Schleicher Miro , Unnikrishnan Vishnu , Perez-Carpena Patricia , Pryss Rüdiger , Robles-Bolivar Paula , Rose Matthias , Schecklmann Martin , Schiele Tabea , Schobel Johannes , Spiliopoulou Myra , Stark Sabine , Vogel Carsten , Wunder Nina , Zachou Zoi , Langguth Berthold 
Published: July 2023

Abstract
Background
Tinnitus is a leading cause of disease burden globally. Several therapeutic strategies are recommended in guidelines for the reduction of tinnitus distress; however, little is known about the potentially increased effectiveness of a combination of treatments and personalized treatments for each tinnitus patient.

Methods
Within the Unification of Treatments and Interventions for Tinnitus Patients project, a multicenter, randomized clinical trial is conducted with the aim to compare the effectiveness of single treatments and combined treatments on tinnitus distress (UNITI-RCT). Five different tinnitus centers across Europe aim to treat chronic tinnitus patients with either cognitive behavioral therapy, sound therapy, structured counseling, or hearing aids alone, or with a combination of two of these treatments, resulting in four treatment arms with single treatment and six treatment arms with combinational treatment. This statistical analysis plan describes the statistical methods to be deployed in the UNITI-RCT.

Discussion
The UNITI-RCT trial will provide important evidence about whether a combination of treatments is superior to a single treatment alone in the management of chronic tinnitus patients. This pre-specified statistical analysis plan details the methodology for the analysis of the UNITI trial results.

Trial registration
ClinicalTrials.gov NCT04663828. The trial is ongoing. Date of registration: December 11, 2020. All patients that finished their treatment before 19 December 2022 are included in the main RCT analysis.
Assisted ambulation to improve health outcomes for older medical inpatients (AMBULATE): study protocol for a randomized controlled trial
Authors: Johnson Joshua K. , Hamilton Aaron C. , Hu Bo , Pack Quinn R. , Lindenauer Peter K. , Fox Robert J. , Hashmi Ardeshir , Siegmund Lee Anne , Burchill Christian N. , Taksler Glen B. , Goto Toyomi , Stilphen Mary , Rothberg Michael B. 
Published: July 2023

AbstractBackgroundHospitalized older adults spend as much as 95% of their time in bed, which can result in adverse events and delay recovery while increasing costs. Observational studies have shown that general mobility interventions (e.g., ambulation) can mitigate adverse events and improve patients’ functional status. Mobility technicians (MTs) may address the need for patients to engage in mobility interventions without overburdening nurses. There is no data, however, on the effect of MT-assisted ambulation on adverse events or functional status, or on the cost tradeoffs if a MT were employed. The AMBULATE study aims to determine whether MT-assisted ambulation improves mobility status and decreases adverse events for older medical inpatients. It will also include analyses to identify the patients that benefit most from MT-assisted mobility and assess the cost-effectiveness of employing a MT.MethodsThe AMBULATE study is a multicenter, single-blind, parallel control design, individual-level randomized trial. It will include patients admitted to a medical service in five hospitals in two regions of the USA. Patients over age 65 with mild functional deficits will be randomized using a block randomization scheme. Those in the intervention group will ambulate with the MT up to three times daily, guided by the Johns Hopkins Mobility Goal Calculator. The intervention will conclude at hospital discharge, or after 10 days if the hospitalization is prolonged. The primary outcome is the Short Physical Performance Battery score at discharge. Secondary outcomes are discharge disposition, length of stay, hospital-acquired complications (falls, venous thromboembolism, pressure ulcers, and hospital-acquired pneumonia), and post-hospital functional status.DiscussionWhile functional decline in the hospital is multifactorial, ambulation is a modifiable factor for many patients. The AMBULATE study will be the largest randomized controlled trial to test the clinical effects of dedicating a single care team member to facilitating mobility for older hospitalized patients. It will also provide a useful estimation of cost implications to help hospital administrators assess the feasibility and utility of employing MTs.Trial registrationRegistered in the United States National Library of Medicine clinicaltrials.gov (# NCT05725928). February 13, 2023.
The probability distributions of the movement of dairy and beef cattle in Japan: a data note
Authors: Murato Yoshinori , Hayama Yoko , Kondo Sonoko , Sawai Kotaro , Yamaguchi Emi , Yamamoto Takehisa 
Published: July 2023

Abstract
Objectives
Animal movement is an important factor in the transmission of infectious diseases among livestock. A better understanding of animal movement characteristics provides a more reliable estimation of disease spread and promotes modeling studies. In Japan, all the cattle movement information is recorded in a national database called the Individual Cattle Identification Register (ICIR).” Our previous studies using this information demonstrated heterogeneity in the movement of dairy and beef cows according to location, season, and age. The present study describes the probability distributions of the movement of Japanese dairy and beef cows in the following month on a regional basis.

Data description
This publication contains four probability distribution datasets for the predicted locations of dairy and beef cows in Japan in the following month, which were developed using individual cattle movement information obtained from the ICIR. These datasets provide information on cattle movement in the following month on a regional basis, given properties such as birth region, location, time, and age.
Obstructive lithiasis of the lower bile duct discovered four decades after cholecystectomy and its management by ideal choledochotomy: a case report
Authors: Kamla Joël Igor , Bang Guy Aristide , Tochie Joel Noutakdie , Tchuenkam Landry Wakheu , Essomba Arthur Georges 
Published: July 2023

AbstractBackgroundResidual lithiasis is the presence of stones in the common bile duct, ignored after one or more biliary interventions. We report an atypical case of chronic symptomatic lithiasis of the lower bile duct occurring 41 years after biliary surgery, managed successfully by ideal choledochotomy.Case presentationA 68-year-old Black African female with several past laparotomies including a cholecystectomy forty-one years ago presented with hepatic colic-type pain that had been intermittent for several years but worsened recently. Her clinical, biological, and imaging test assessments were suggestive of a residual obstructive lithiasis of the lower common bile duct. Through an open right subcostal laparotomy approach, a dilated bile duct of approximately 3 cm was found and managed by transverse choledochotomy in which the stone was extracted in retrograde manner. After confirmation of disobstruction, a primitive bile duct suture without biliary drainage was performed and a tubular drain was positioned under the liver. The postoperative course was uneventful at follow-up of 30 days.ConclusionResidual choledocholithiasis can be avoided. We performed an ideal choledochotomy, of which the follow-up was simple.
Dendritic cells mediated by small extracellular vesicles derived from MSCs attenuated the ILC2 activity via PGE2 in patients with allergic rhinitis
Authors: Liu Xiao-Qing , Peng Ya-Qi , Huang Long-Xin , Li Chan-Gu , Kuang Peng-Peng , Chen De-Hua , Wu Zi-Cong , He Bi-Xin , Zhou Zhi-Rou , Fu Qing-Ling 
Published: July 2023

Abstract
Background
Mesenchymal stromal cells-derived small extracellular vesicles (MSC-sEVs) have recently attracted considerable attention because of their therapeutic potential in various immune diseases. We previously reported that MSC-sEVs could exert immunomodulatory roles in allergic airway inflammation by regulating group 2 innate lymphoid cell (ILC2) and dendritic cell (DC) functions. Therefore, this study aimed to investigate the indirect effects of MSC-sEVs on ILC2s from patients with allergic rhinitis (AR) via DCs.

Methods
Here, we isolated sEVs from induced pluripotent stem cells-MSCs using anion-exchange chromatography and mature DCs (mDCs) were treated with MSC-sEVs. sEV-mDCs were co-cultured with peripheral blood mononuclear cells from patients with AR or purified ILC2s. The levels of IL-13 and GATA3 in ILC2s were examined by flow cytometry. Bulk RNA sequence for mDCs and sEV-mDCs was employed to further probe the potential mechanisms, which were then validated in the co-culture systems.

Results
sEV-mDCs showed impaired capacity in priming the levels of IL-13 and GATA3 in ILC2s when compared with mDCs. Furthermore, there was higher PGE2 and IL-10 production from sEV-mDCs, and the blockade of them especially the former one reversed the inhibitory effects of sEV-mDCs.

Conclusions
We demonstrated that MSC-sEVs were able to dampen the activating effects of mDCs on ILC2s in patients with AR. Mechanismly, the PGE2-EP2/4 axis played an essential role in the immunomodulatory effects of sEV-mDCs on ILC2s. Herein, we provided new insights into the mechanism underlying the therapeutic effects of MSC-sEVs in allergic airway inflammation.
Animal behaviour on the move: the use of auxiliary information and semi-supervision to improve behavioural inferences from Hidden Markov Models applied to GPS tracking datasets
Authors: Saldanha Sarah , Cox Sam L. , Militão Teresa , González-Solís Jacob 
Published: July 2023

Abstract
Background
State-space models, such as Hidden Markov Models (HMMs), are increasingly used to classify animal tracks into behavioural states. Typically, step length and turning angles of successive locations are used to infer where and when an animal is resting, foraging, or travelling. However, the accuracy of behavioural classifications is seldom validated, which may badly contaminate posterior analyses. In general, models appear to efficiently infer behaviour in species with discrete foraging and travelling areas, but classification is challenging for species foraging opportunistically across homogenous environments, such as tropical seas. Here, we use a subset of GPS loggers deployed simultaneously with wet-dry data from geolocators, activity measurements from accelerometers, and dive events from Time Depth Recorders (TDR), to improve the classification of HMMs of a large GPS tracking dataset (478 deployments) of red-billed tropicbirds (Phaethon aethereus), a poorly studied pantropical seabird.

Methods
We classified a subset of fixes as either resting, foraging or travelling based on the three auxiliary sensors and evaluated the increase in overall accuracy, sensitivity (true positive rate), specificity (true negative rate) and precision (positive predictive value) of the models in relation to the increasing inclusion of fixes with known behaviours.

Results
We demonstrate that even with a small informed sub-dataset (representing only 9% of the full dataset), we can significantly improve the overall behavioural classification of these models, increasing model accuracy from 0.77 ± 0.01 to 0.85 ± 0.01 (mean ± sd). Despite overall improvements, the sensitivity and precision of foraging behaviour remained low (reaching 0.37 ± 0.06, and 0.06 ± 0.01, respectively).

Conclusions
This study demonstrates that the use of a small subset of auxiliary data with known behaviours can both validate and notably improve behavioural classifications of state space models of opportunistic foragers. However, the improvement is state-dependant and caution should be taken when interpreting inferences of foraging behaviour from GPS data in species foraging on the go across homogenous environments.
Combining cognitive theory and data driven approaches to examine students’ search behaviors in simulated digital environments
Authors: Tenison Caitlin , Sparks Jesse R. 
Published: July 2023

AbstractBackgroundDigital Information Literacy (DIL) refers to the ability to obtain, understand, evaluate, and use information in digital contexts. To accurately capture various dimensions of DIL, assessment designers have increasingly looked toward complex, interactive simulation-based environments that afford more authentic learner performances. These rich assessment environments can capture process data produced by students’ goal driven interactions with digital sources but linking this data to inferences about the target constructs introduces significant measurement challenges which cognitive theory can help us address.MethodsIn this paper, we analyzed data generated from a simulated web search tool embedded within a theoretically-grounded virtual world assessment of multiple-source inquiry skills. We describe a multi-step clustering approach to identify patterns in student’s search processes by bringing together theory-informed process data indicators and sequence clustering methods.ResultsWe identified four distinct search behaviors captured in students’ process data. We found that these search behaviors differed both in their contribution to the web search tool subscores as well as correlations with task level multiple-source inquiry subconstructs such as locating, evaluating, and synthesizing information. We argue that the search behaviors reflect differences in how students generate and update their task goals.ConclusionThe data-driven approach we describe affords a qualitative understanding of student strategy use in a complex, dynamic simulation- and scenario-based environment. We discuss some of the strengths and challenges of using a theoretical understanding of multiple-source inquiry to inform how we processed, analyzed, and interpreted the data produced from this assessment tool and the implications of this approach for future research and development.
Awareness routing algorithm in vehicular ad-hoc networks (VANETs)
Authors: choudhary Deepak , Pahuja Roop 
Published: July 2023

AbstractThe behavior of a Vehicle Ad hoc Network (VANETs) is extremely unpredictable due to the high mobility and random network topology inherent to the nature of VANETs. Several problems, including frequent connection failures, scalability, multi-hop data transfer, and data loss, impact the performance of Transmission Control Protocols (TCP) in such wireless ad hoc networks. This study proposes using zone-based routing with consideration for mobility in VANETs as a means of avoiding this issue. A hybrid optimization approach is introduced and used to the routing process. Both Ant Colony Optimization (ACO) and Artificial Bee Colony Optimization (ABCO) are components of the hybrid algorithm (ABC). Link stability and Residual energy provide the basis of the fitness function. Several measures, including delivery ratio, time, and overhead, are used to evaluate the effectiveness of the suggested method. A comparison of the suggested method's efficiency with that of other algorithms.
The Restrictive Red Blood Cell Transfusion Strategy for Critically Injured Patients (RESTRIC) trial: a cluster-randomized, crossover, non-inferiority multicenter trial of restrictive transfusion in trauma
Authors: Hayakawa Mineji , Tagami Takashi , Kudo Daisuke , Ono Kota , Aoki Makoto , Endo Akira , Yumoto Tetsuya , Matsumura Yosuke , Irino Shiho , Sekine Kazuhiko , Ushio Noritaka , Ogura Takayuki , Nachi Sho , Irie Yuhei , Hayakawa Katsura , Ito Yusuke , Okishio Yuko , Muronoi Tomohiro , Kosaki Yoshinori , Ito Kaori , Nakatsutsumi Keita , Kondo Yutaka , Ueda Taichiro , Fukuma Hiroshi , Saisaka Yuichi , Tominaga Naoki , Kurita Takeo , Nakayama Fumihiko , Shibata Tomotaka , Kushimoto Shigeki 
Published: July 2023

Abstract
Background
The efficacies of fresh frozen plasma and coagulation factor transfusion have been widely evaluated in trauma-induced coagulopathy management during the acute post-injury phase. However, the efficacy of red blood cell transfusion has not been adequately investigated in patients with severe trauma, and the optimal hemoglobin target level during the acute post-injury and resuscitation phases remains unclear. Therefore, this study aimed to examine whether a restrictive transfusion strategy was clinically non-inferior to a liberal transfusion strategy during the acute post-injury phase.

Methods
This cluster-randomized, crossover, non-inferiority multicenter trial was conducted at 22 tertiary emergency medical institutions in Japan and included adult patients with severe trauma at risk of major bleeding. The institutions were allocated a restrictive or liberal transfusion strategy (target hemoglobin levels: 7–9 or 10–12 g/dL, respectively). The strategies were applied to patients immediately after arrival at the emergency department. The primary outcome was 28-day survival after arrival at the emergency department. Secondary outcomes included transfusion volume, complication rates, and event-free days. The non-inferiority margin was set at 3%.

Results
The 28-day survival rates of patients in the restrictive (n = 216) and liberal (n = 195) strategy groups were 92.1% and 91.3%, respectively. The adjusted odds ratio for 28-day survival in the restrictive versus liberal strategy group was 1.02 (95% confidence interval: 0.49–2.13). Significant non-inferiority was not observed. Transfusion volumes and hemoglobin levels were lower in the restrictive strategy group than in the liberal strategy group. No between-group differences were noted in complication rates or event-free days.

Conclusions
Although non-inferiority of the restrictive versus liberal transfusion strategy for 28-day survival was not statistically significant, the mortality and complication rates were similar between the groups. The restrictive transfusion strategy results in a lower transfusion volume.
Trial registration number:umin.ac.jp/ctr: UMIN000034405, registration date: 8 October 2018.
Adverse childhood experiences, child behavioral health needs, and family characteristics associated with the presence of a firearm in the home: a survey of parents in Chicago
Authors: Attridge Megan M. , Heffernan Marie E. , Bendelow Anne , Menker Carly G. , Davis Matthew M. , Sheehan Karen 
Published: July 2023

Abstract
Background
Firearm violence is the leading cause of pediatric mortality in the USA. The presence of a firearm in the home poses an immense risk to children with increased rates of suicide and unintentional injury by firearm. Recent literature has not explored child ACEs and child behavioral health needs with the presence of a firearm in the home. The objective of this study was to explore an association between these factors, parent health, family experience with firearm violence, and demographics, and the presence of a firearm in the home.

Results
Overall, 382 of 1,436 (weighted to 22.0%) responding parents reported the presence of a firearm in the home. In an adjusted model, the odds ratio of firearm presence increased incrementally with a child’s increasing exposure to ACEs. Compared to a child in the household exposed to no ACEs, a child in the household exposed to two or more ACEs was associated with a 5.16 times higher odds of firearm presence in the home (95% confidence interval (CI) 2.92–9.10). Similarly, a child in the household who had used behavioral health services was associated with a 2.10 times higher odds of firearm presence in the home (95% CI 1.35–3.26), compared to a child in the household who had not. Presence of firearm in the home was also associated with higher household income, younger parent age (under 35 years), and male parent gender.

Conclusions
Chicago parents have higher odds of reporting the presence of a firearm in the home when living in a household with a child exposed to ACEs and with behavioral health needs. These findings could inform future public health interventions and targeted safe storage messaging to prevent pediatric firearm injury in the home.