bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunohistochemical characterization of a steroid-secreting oncocytic adrenal carcinoma responsible for paraneoplastic hyperparathyroidism
Authors: Haissaguerre Magalie , Louiset Estelle , Juhlin Christofer C , Stenman Adam , Laurent Christophe , Trouette Hélène , Lefebvre Hervé , Tabarin Antoine 
Published: March 2023

AbstractWe report a unique case of a 44-year-old man with paraneoplastic hyperparathyroidism due to an oncocytic adrenocortical carcinoma (stage pT3N0R0M0, ENSAT 2 with a 4% Ki-67). Paraneoplastic hyperparathyroidism was associated with mild adrenocorticotropic hormone (ACTH)–independent hypercortisolism and increased estradiol secretion responsible for gynecomastia and hypogonadism. Biological investigations performed in blood samples from peripheral and adrenal veins revealed that the tumor secreted parathyroid hormone (PTH) and estradiol. Ectopic PTH secretion was confirmed by abnormally high expression of PTH mRNA and clusters of PTH immunoreactive cells in the tumor tissue. Double-immunochemistry studies and analysis of contiguous slides for the expression of PTH and steroidogenic markers (scavenger receptor class B type 1 [SRB1], 3β-hydroxysteroid dehydrogenase [3β-HSD], and aromatase) were performed. The results suggested the presence of two tumor cells subtypes with large cells with voluminous nuclei producing only PTH and that were distinct from steroid-producing cells.
Root exudate concentrations of indole-3-acetic acid (IAA) and abscisic acid (ABA) affect maize rhizobacterial communities at specific developmental stages
Authors: Lopes Lucas Dantas , Futrell Stephanie L , Bergmeyer Emma , Hao Jingjie , Schachtman Daniel P 
Published: March 2023

Abstract
Root exudates shape the rhizosphere microbiome, but little is known about the specific compounds in root exudates that are important. Here, we investigated the impacts of the plant-synthesized phytohormones indole-3-acetic acid (IAA) and abscisic acid (ABA) exuded by roots on the maize rhizobacterial communities. To identify maize genotypes that differed in the root exudate concentrations of IAA and ABA, we screened hundreds of inbred lines using a semi-hydroponic system. Twelve genotypes with variable exudate concentrations of IAA and ABA were selected for a replicated field experiment. Bulk soil, rhizosphere, and root endosphere samples were collected at two vegetative and one reproductive maize developmental stage. IAA and ABA concentrations in rhizosphere samples were quantified by liquid chromatography–mass spectrometry. The bacterial communities were analyzed by V4 16S rRNA amplicon sequencing. Results indicated that IAA and ABA concentrations in root exudates significantly affected the rhizobacterial communities at specific developmental stages. ABA impacted the rhizosphere bacterial communities at later developmental stages, whereas IAA affected the rhizobacterial communities at the vegetative stages. This study contributed to our knowledge about the influence that specific root exudate compounds have on the rhizobiome composition, showing that the phytohormones IAA and ABA exuded by roots have a role in the plant–microbiome interactions.
Reframing Rousseau: Art, Literature and Attachment in Émile
Authors: Tidman Gemma 
Published: March 2023

Abstract
This article sheds light on both Jean-Jacques Rousseau’s aesthetic thought and his role in the emergence of modern ideas of littérature, by revisiting his novel-cum-treatise, Émile, ou de l’éducation (1762). Contrary to much scholarship that has minimized Rousseau’s interest in aesthetics, and in the visual arts in particular, the article reframes Rousseau as a fundamentally aesthetic thinker. With reference to Jacques Derrida’s concept (via Kant) of the parergon, it argues that Rousseau uses the image of the frame – literal or figurative – to delineate his ideas about the ideal visual and literary arts, and how they should affect spectators or readers. By reading Rousseau alongside Rita Felski, the article historicizes the affective turn in postcritique today. Focusing on Émile’s encounters with the literary arts, it shows that the modern idea of literature as aesthetically pleasing texts that (by dint of their aesthetic quality) induce an affective and ethical response, was attached to the French word littérature earlier than has been claimed, by an author often considered ‘anti-literature’.
Longitudinal Associations Between Disaster Damage and Falls/Fear of Falling in Older Adults: 9-Year Follow-Up of Survivors of the 2011 Great East Japan Earthquake and Tsunami
Authors: Wang Yuhang , Zhang Chenggang , Hikichi Hiroyuki , Kawachi Ichiro , Li Xiaoyu 
Published: March 2023

AbstractBackground and ObjectivesFear of falling and falls are common in older adults. However, their associations with natural disaster exposures remain poorly understood. This study aims to examine longitudinal associations between disaster damage with fear of falling/falls among older disaster survivors.Research Design and MethodsIn this natural experiment study, the baseline survey (4,957 valid responses) took place 7 months before the 2011 Great East Japan Earthquake and Tsunami, and 3 follow-ups were conducted in 2013, 2016, and 2020. Exposures were different types of disaster damage and community social capital. Outcomes were fear of falling and falls (including incident and recurrent falls). We used lagged outcomes in logistic models adjusting for covariates and further examined instrumental activities of daily living (IADLs) as a mediator.ResultsThe baseline sample had a mean (standard deviation) age of 74.8 (7.1) years; 56.4% were female. Financial hardship was associated with fear of falling (odds ratio (OR), 1.75; 95% confidence interval (CI) [1.33, 2.28]) and falls (OR, 1.29; 95% CI [1.05, 1.58]), especially recurrent falls (OR, 3.53; 95% CI [1.90, 6.57]). Relocation was inversely linked with fear of falling (OR, 0.57; 95% CI [0.34, 0.94]). Social cohesion was protectively associated with fear of falling (OR, 0.82; 95% CI [0.71, 0.95]) and falls (OR, 0.88; 95% CI [0.78, 0.98]) whereas social participation increased the risk of these issues. IADL partially mediated observed associations between disaster damage and fear of falling/falls.Discussion and ImplicationsExperiences of material damage rather than psychological trauma were associated with falls and fear of falling, and the increased risk of recurrent falls revealed a process of cumulative disadvantage. Findings could inform targeted strategies for protecting older disaster survivors.
Fault identification and reliability evaluation using an SVM model based on 3-D seismic data volume
Authors: Ren Ke , Zou Guangui , Zhang Shaomin , Peng Suping , Gong Fei , Liu Yanhai 
Published: March 2023

SUMMARY
As an important method of 3-D seismic exploration, intelligent structural interpretation has been improved in recent years. Traditional human–computer interaction explanations typically assess fault risk on a hierarchical basis. However, the majority of intelligent fault interpretations utilize binary classification methods, which limits the utility and development of this technology to a certain extent. In order to break this limitation, a fault risk assessment scheme based on particle swarm optimization (PSO) and support vector machine (SVM) posterior probability model has been proposed. In this study, the fault exposure situations for 11 wells and 4 roadways of a coal mine in Yunnan Province, China, were identified. A total of 15 559 data points with known fault and non-fault information were obtained in the target coal seam. Based on these data, SVM fault recognition models were constructed. The key parameters of the SVM models were optimized by PSO, and the test accuracy of each model was above 87 per cent. Meanwhile, the SVM posterior probability model was introduced to evaluate the fault identification results in the study area. The SVM posterior probability model was used to convert the decision value of a standard SVM into a posterior probability value. Probability values in the range of [0, 0.5) are evaluated as non-fault points, [0.5, 0.7) as ‘unreliable’ fault points, [0.7, 0.9) as ‘less reliable’ fault points, and [0.9, 1] as ‘reliable’ fault points. By constructing data sets with different sample numbers and fault types, the influence of each factor on the evaluation of the SVM posterior probability model was analysed. The results show that the SVM posterior probability model can be used to hierarchically evaluate fault risk in the study area and provide decision makers with more accurate information for decision making.
La inclusión relacional: examining neoliberal tensions, relational opportunities, and fixed understandings in diversity, equity, and inclusion work in the Global South
Authors: Villamil Astrid M , Mendoza Pilar , Hoyos Ensuncho Maryluz , Reina Zambrano Juanita 
Published: March 2023

AbstractThis study explored efforts of staff, faculty, and students at a Colombian university to materialize diversity, inclusion, and equity (DEI) programs in its institutional practices. Using Communicative Constitution of Organization (CCO) as an informing paradigm, this study proposed to understand institutional DEI as interconnected communicative practices of relational ontology. In addition, this study constituted an effort to recognize novel contours that delink knowledge from hegemonic North Atlantic and Eurocentric paradigms and interrogate epistemologies “embedded in capitalist networks of power” (Dutta & Pal, 2020).Through ethnographic work and in-depth interviews with 23 organizational members, this qualitative study unearthed two tension-laden themes that described (a) the (dis)ordering nature of DEI meanings and (b) the sociality/materiality entanglement of DEI efforts at a Colombia institution of higher education. Combined, our results highlight an inseparable interplay of sociomaterial discourses in DEI and the imperative need to question and contest transnational discourses from North Atlantic and Eurocentric contexts.
Antibody Responses to the SARS-CoV-2 Ancestral Strain and Omicron Variants in Moderna mRNA-1273 Vaccinated Active-Duty US Navy Sailors and Marines
Authors: Sun Peifang , Balinsky Corey A , Jiang Le , Jani Vihasi , Long Tran Khanh , Cheng Ying , Serote Mary Ann , Smith Andrew B , Fears Burnetta F , Gatrell Stephanie K , Sugiharto Victor A , Chen Huawei , Zhang Zhiwen , Belinskaya Tatyana , Qiu Qi , Graham William D , Schilling Megan A , Jones Anthony R , Corson Karen S , Martin Nicholas J , Letizia Andrew G , Hontz Robert D 
Published: March 2023

Abstract
Omicron and its subvariants have steadily gained greater capability of immune escape compared to other variants of concern, resulting in an increased incidence of reinfections even among vaccinated individuals. We evaluated the antibody response to Omicron BA.1, BA.2, and BA.4/5 in US military members vaccinated with the primary 2-dose series of Moderna mRNA-1273 in a cross-sectional study. While nearly all vaccinated participants had sustained spike (S) IgG and neutralizing antibodies (ND50) to the ancestral strain, only 7.7% participants had detectable ND50 to Omicron BA.1 at 8 months postvaccination. The neutralizing antibody response to BA.2 and BA.5 was similarly reduced. The reduced antibody neutralization of Omicron correlated with the decreased antibody binding to the receptor-binding domain. The participants’ seropositivity to the nuclear protein positively correlated with ND50. Our data emphasizes the need for continuous vigilance in monitoring for emerging variants and the need to identify potential alternative targets for vaccine design.
Conventional versus extended-pulsed fidaxomicin dosing in patients at high risk of recurrence ofClostridioides difficileinfection: a propensity score analysis
Authors: Escudero-Sánchez Rosa , Rubio Martín Elena , Vizcarra Pilar , Braojos Sánchez Francisco , Diaz Gago Álvaro , Del Campo Albendea Laura , Muriel Alfonso , Halperin Ana , Ponce Alonso Manuel , Moreno Guillén Santiago , Cobo Javier 
Published: March 2023

AbstractIntroductionThe main challenge in the treatment of Clostridioides difficile infection (CDI) is to reduce recurrence rates. Fidaxomicin improves the recurrence rate of CDI compared with vancomycin. Extended-pulsed dosing of fidaxomicin was associated with lower recurrence rates in one clinical trial but has never been directly compared with conventional fidaxomicin dosing.MethodsTo compare the recurrence rate of fidaxomicin conventional dosing (FCD) and fidaxomicin in extended-pulsed dosing (FEPD) in conditions of clinical practice at a single institution. We performed propensity score matching taking the variables age, severity and previous episode as confounders to evaluate patients with a similar recurrence risk.ResultsIn total, 254 episodes of CDI treated with fidaxomicin were evaluated: 170 (66.9%) received FCD, and 84 (33.1%) received FEPD. More patients who received FCD were hospitalized for CDI, had severe CDI and had a diagnosis based on toxin detection. In contrast, the proportion of patients receiving proton pump inhibitors was higher in those receiving FEPD. The crude recurrence rates in FCD- and FEPD-treated patients were 20.0% and 10.7%, respectively (OR:0.48; 95% CI 0.22–1.05; P = 0.068). We did not find any differences in CDI recurrence rate in patients receiving FEPD versus FCD (OR = 0.74; 95% CI 0.27–2.04) by propensity score analysis.ConclusionsAlthough the recurrence rate with FEPD was numerically lower than that observed with FCD, we have not been able to show that the recurrence rate of CDI is different depending on the dosage regimen of fidaxomicin. Clinical trials or large observational studies comparing the two dosing regimens of fidaxomicin are needed.
Three-dimensional seismic data reconstruction via partial sum of tensor nuclear norm minimization
Authors: Zhang Xingli , Zhang Yaping , Liu Zuogang , Wang Hongjuan 
Published: March 2023

AbstractRank-reduction has become a hotspot in seismic data reconstruction research in recent years. Traditional rank-reduction methods generally use the nuclear norm as a convex proxy for rank, but these methods overly penalize large singular values, leading to reconstruction results that deviate from the optimal solution. In this paper, we propose a tensor robust principal component analysis model with minimization of the partial sum of tensor nuclear norm for three-dimensional (3D) reconstruction of seismic data. The partial sum of tensor nuclear norm minimizes only the partial singular values and can approximate the rank function more accurately. TRPCA can accurately recover the 3D tensor corrupted by sparse errors, improving the accuracy of seismic data reconstruction. The experimental results of the simulated data and real data show that the reconstruction effect of the proposed method on the 3D seismic data is better than the compared methods.
Population distribution and causes of mortality of smooth-coated otters, Lutrogale perspicillata, in Singapore
Authors: Shivram Anusha , Sivasothi N , Hsu Chia-Da , Hodges Karen E 
Published: March 2023

Abstract
Smooth-coated otters (Lutrogale perspicillata) were transient in Singapore before one resident family group was observed in 1998, presumably having recolonized from Peninsular Malaysia. A population survey in 2017 revealed a minimum of 11 groups and 79 individuals. Since then, movements of otter groups within urban areas have led to increasing numbers of human–otter encounters, including conflicts. We determined the current abundance, population structure, and distribution of smooth-coated otters in Singapore. We assessed seven sampling zones nationwide through verified sighting records and social media. Mortality records from 2019 to 2021 were sourced from the Otter Working Group and Wildlife Reserves Singapore. In early 2021, there were a minimum of 17 groups and 170 individuals. Groups ranged from 2 to 24 individuals. Smooth-coated otters occupy coastal areas, waterways, reservoirs, and sites within the city center in urban gardens and ponds. Following territorial conflicts at waterways, smooth-coated otter groups moved into the urban matrix. Vehicle collisions are the main cause of mortality and are frequent at dams separating freshwater and coastal habitats. While there is a clear increase in smooth-coated otter numbers since 2017, there remain multiple natural and human-caused threats to otter persistence.
Focused NPIs in Statements and Questions
Authors: Jeong Sunwoo , Roelofsen Floris 
Published: March 2023

AbstractNegative Polarity Items (NPIs) with emphatic prosody such as ANY or EVER, and minimizers such as lift a finger or sleep a wink are known to generate particular contextual inferences that are absent in the case of non-emphatic NPIs such as unstressed any or ever. It remains an open question, however, what the exact status of these inferences is and how they come about. In this paper, we analyze these cases as NPIs bearing focus, and examine the interaction between focus semantics and the lexical semantics of NPIs across statements and questions. In the process, we refine and expand the empirical landscape by demonstrating that focused NPIs give rise to a variety of apparently heterogeneous contextual inferences, including domain widening in statements and inferences of negative bias in questions. These inferences are further shown to be modulated in subtle ways depending on the specific clause-type in which the NPI occurs (e.g., polar questions vs. wh-questions) and the type of emphatic NPI involved (e.g., ANY vs. lift a finger). Building on these empirical observations, we propose a unified account of NPIs which posits a single core semantic operator, even, across both focused and unfocused NPIs. What plays a central role in our account is the additive component of even, which we formulate in such a way that it applies uniformly across statements and questions. This additive component of even, intuitively paraphrased as the implication that all salient focus alternatives of the prejacent of the operator must be settled in the doxastic state of the speaker, is selectively activated depending on the presence of focus alternatives, and is shown to be able to derive all the observed contextual inferences stemming from focused NPIs, both in statements and in questions.
A tell tail sign: a conserved C-terminal tail-anchor domain targets a subset of pathogen effectors to the plant endoplasmic reticulum
Authors: Breeze Emily , Vale Victoria , McLellan Hazel , Pecrix Yann , Godiard Laurence , Grant Murray , Frigerio Lorenzo 
Published: March 2023

Abstract
The endoplasmic reticulum (ER) is the entry point to the secretory pathway and, as such, is critical for adaptive responses to biotic stress, when the demand for de novo synthesis of immunity-related proteins and signalling components increases significantly. Successful phytopathogens have evolved an arsenal of small effector proteins which collectively reconfigure multiple host components and signalling pathways to promote virulence; a small, but important, subset of which are targeted to the endomembrane system including the ER. We identified and validated a conserved C-terminal tail-anchor motif in a set of pathogen effectors known to localize to the ER from the oomycetes Hyaloperonospora arabidopsidis and Plasmopara halstedii (downy mildew of Arabidopsis and sunflower, respectively) and used this protein topology to develop a bioinformatic pipeline to identify putative ER-localized effectors within the effectorome of the related oomycete, Phytophthora infestans, the causal agent of potato late blight. Many of the identified P. infestans tail-anchor effectors converged on ER-localized NAC transcription factors, indicating that this family is a critical host target for multiple pathogens.
Evidence for a bottom-light initial mass function in massive star clusters
Authors: Baumgardt H , Hénault-Brunet V , Dickson N , Sollima A 
Published: March 2023

ABSTRACT
We have determined stellar mass functions of 120 Milky Way globular clusters and massive Large Magellanic Cloud/Small Magellanic Cloud star clusters based on a comparison of archival Hubble Space Telescope photometry with a large grid of direct N-body simulations. We find a strong correlation of the global mass function slopes of star clusters with both their internal relaxation times and their lifetimes. Once dynamical effects are being accounted for, the mass functions of most star clusters are compatible with an initial mass function described by a broken power-law distribution N(m) ∼ mα with break masses at 0.4 and 1.0 M⊙ and mass function slopes of αLow = −0.3 for stars with masses m &lt; 0.4 M⊙, αHigh = −2.30 for stars with m &gt; 1.0 M⊙, and αMed = −1.65 for intermediate-mass stars. Alternatively, a lognormal mass function with a characteristic mass log MC = −0.36 and width σC = 0.28 for low-mass stars and a power-law mass function for stars with m &gt; 1 M⊙ also fit our data. We do not find a significant environmental dependence of the initial mass function on cluster mass, density, global velocity dispersion, or metallicity. Our results lead to a larger fraction of high-mass stars in globular clusters compared to canonical Kroupa/Chabrier mass functions, increasing the efficiency of self-enrichment in clusters and helping to alleviate the mass budget problem of multiple stellar populations in globular clusters. By comparing our results with direct N-body simulations, we finally find that only simulations in which most black holes are ejected by natal birth kicks correctly reproduce the observed correlations.
Probing the global dust properties and cluster formation potential of the giant molecular cloud G148.24+00.41
Authors: Rawat Vineet , Samal M R , Walker D L , Zavagno A , Tej A , Marton G , Ojha D K , Elia Davide , Chen W P , Jose J , Eswaraiah C 
Published: March 2023

ABSTRACT
Clouds more massive than about 105 M⊙ are potential sites of massive cluster formation. Studying the properties of such clouds in the early stages of their evolution offers an opportunity to test various cluster formation processes. We make use of CO, Herschel, and UKIDSS observations to study one such cloud, G148.24+00.41. Our results show the cloud to be of high mass ($\sim \, 1.1\times 10^5$ M⊙), low dust temperature (∼ 14.5 K), nearly circular (projected radius ∼ 26 pc), and gravitationally bound with a dense gas fraction of ∼18 per cent and a density profile with a power-law index of ∼−1.5. Comparing its properties with those of nearby molecular clouds, we find that G148.24+00.41 is comparable to the Orion-A molecular cloud in terms of mass, size, and dense gas fraction. From our analyses, we find that the central area of the cloud is actively forming protostars and is moderately fractal with a Q-value of ∼ 0.66. We also find evidence of global mass-segregation with a degree of mass-segregation (ΛMSR) ≈ 3.2. We discuss these results along with the structure and compactness of the cloud, the spatial and temporal distribution of embedded stellar population and their correlation with the cold dust distribution, in the context of high-mass cluster formation. We compare our results with models of star cluster formation, and conclude that the cloud has the potential to form a cluster in the mass range ∼ 2000–3000 M⊙ through dynamical hierarchical collapse and assembly of both gas and stars.