bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous pneumothorax with isolated pulmonary Langerhans cell histiocytosis in an adult case: A common manifestation of rare disease
Authors: Samareh Fekri Mitra , Salajegheh Faranak , Nakhaie Mohsen , Rezaei Zadeh Rukerd Mohammad 
Published: June 2023

Key Clinical MessagePulmonary Langerhans cell histiocytosis should be evaluated even in adults with no previous medical history and no history of cigarette smoking who have spontaneous pneumothorax and evidence of multiple lung cystic lesions, and other organs should also be checked for multi organ Langerhans cell histiocytosis involvement.AbstractA 30‐year‐old man presented with sudden chest pain and evidence of multiple cystic lesions in both upper and lower lobes of lungs, as well as left‐sided pneumothorax in high resolution computed tomography. In lung samples, hematoxylin and eosin‐ stained sections and IHC for CD1a, S100, and BRAF V600 were positive. The patient was diagnosed with isolated pulmonary Langerhans cell histiocytosis and was treated accordingly.
Two‐step sequential management for hip arthroplasty after hip joint gunshot injury: A case report
Authors: Zandi Reza , Talebi Shahin , Ehsani Akbar , Nodehi Saeed 
Published: June 2023

Key Clinical MessageCombined fractures of the femoral head and acetabulum due to hip gunshot injuries (GSI) are rare, and there is no preferred treatment option. We present a 35‐year‐old male patient who sustained a right hip GSI. Delayed THA with a two‐step sequential approach is a feasible management in this situation to manage soft tissue and decrease infection rate. At a 1‐year follow‐up visit, the pain was relieved, and the function improved significantly, and he had no complaints.
Mediterranean spotted fever as a non‐endemic disease in the southeast of Iran: Diagnosis and treatment based on specific skin lesion
Authors: Farrokhnia Mehrdad , Shafieipour Sara , Nakhaie Mohsen , Rukerd Mohammad Rezaei Zadeh 
Published: June 2023

Key Clinical MessageRickettsia spp. should be investigated if Tache Noire, as a dark plaque covering a superficial ulcer surrounded by scale, edema, and erythema, are observed, even in non‐endemic areas of Rickettsia spp.AbstractA 31‐year‐old man with fever, dyspnea, abdominal pain, and jaundice has been admitted to the hospital in the southeast of Iran. Due to the presence of a pathognomonic skin lesion (Tache noire), the patient was diagnosed with Mediterranean spotted fever (MSF) and was treated with doxycycline, without waiting for PCR and IFA findings.
Medication‐related osteonecrosis of the jaw leading to sepsis in a patient with rheumatoid arthritis: A case report and clinical implications
Authors: Iwasaki Kazuhiko , Okazaki Akihito 
Published: June 2023

Key Clinical MessageChronic use of bisphosphonates, in combination with immunosuppressive therapy, increases the risk of jaw osteonecrosis. When sepsis occurs in patients receiving bisphosphonate, osteonecrosis of the jaw should be considered a potential source of infection.AbstractReports of medication‐related osteonecrosis of the jaw (MRONJ) accompanied by sepsis are limited. A 75‐year‐old female patient with rheumatoid arthritis, receiving treatment with bisphosphonate and abatacept, developed sepsis secondary to MRONJ. When sepsis occurs in patients receiving bisphosphonate, osteonecrosis of the jaw should be considered a potential source of infection.
Workplace ostracism and turnover intention: A moderated mediation model of job insecurity and coaching leadership
Authors: Zhang Rui , Niu Xiongying , Zhang Baofang 
Published: June 2023

AbstractWorkplace ostracism is prevalent and has profound consequences for both organizations and individuals. Based on the conservation of resources and job demands–resources theories, we propose a moderated mediation model to examine when and how workplace ostracism induces employee turnover intentions in China. We collected 214 valid questionnaires from a two‐wave survey conducted in 28 Chinese hotels. The results indicate that workplace ostracism is positively associated with employees' turnover intentions. Moreover, this relationship is mediated by job insecurity and is stronger when coaching leadership is low. These findings shed light on the role of job insecurity and coaching leadership in the relationship and the importance of mitigating the destructive effects of workplace ostracism. The theoretical and practical implications are discussed.
Pharmacokinetics, Bioequivalence, and Safety of Esomeprazole Magnesium Enteric‐Coated Capsules in Healthy Chinese Subjects
Authors: Jin Juan , Huang Cuiping , Zhu Changhai , Feng Wanni , He Ang , Li Tuo , Wang Lina , Wang Xiaolu , Rao Xiali , Gan Fangliang 
Published: June 2023

AbstractThis bioequivalence study is critically important for drug production. Recently, a local pharmaceutical company produced esomeprazole magnesium enteric‐coated capsules, a major drug to help to eradicate Helicobacter pylori, but the bioequivalence is not well known. The present study aimed to evaluate the bioequivalence of the 2 esomeprazole magnesium enteric‐coated capsules and their pharmacokinetics and safety in 3 biological equivalence trials: fasting, feeding, and mixing. The fasting and mixing trials used single‐centered randomized, open‐label, single‐dose, 2‐treatment, 2‐period, and 2‐sequence crossover design, while the fed trials used single‐centered, randomized, open‐label, single‐dose, 2‐treatment, 3‐period, 3‐sequence partial crossover design. For the fasting and mixing trials, each of the 32 subjects was fasted overnight prior to taking the test preparations or reference preparations. In the fed trial, 54 subjects were given a high‐fat meal 1 hour before the drugs were administered. Blood specimens from all subjects were collected against the light within 14 hours, with the plasma drug concentration being detected by the validated ultra‐performance liquid chromatography–tandem mass spectrometry analysis method. Geometric mean ratio of maximum concentration, the area under the concentration–time curve from time zero to the last measurable concentration, and area under the concentration–time curve from time zero to infinity with 90% confidence interval were calculated. The data from fasting, mixing, and fed trials met the bioequivalence criteria. No serious adverse reactions were found, suggesting that the test and reference preparations of esomeprazole magnesium enteric capsules have similar safety profile.
Model‐Based Dose Selection of Fostemsavir for Pediatric Populations With Multidrug‐Resistant HIV‐1 and Relative Bioavailability Assessment in Healthy Adults
Authors: Thakkar Nilay , Magee Mindy , Goyal Navin , Abberbock Judah , Jones Chris , Taylor James , Chabria Shiven , Moore Katy 
Published: June 2023

AbstractFostemsavir, a prodrug of the first‐in‐class HIV‐1 attachment inhibitor temsavir, is approved for the treatment of multidrug‐resistant HIV‐1 in adults; its use in pediatric populations is currently being studied. Population pharmacokinetic modeling across pediatric weight bands was used to guide pediatric fostemsavir dose selection. Dosing simulations demonstrated that twice‐daily fostemsavir 600‐mg (adult dose) and 400‐mg doses met safety and efficacy criteria for 35 kg or greater and 20 or greater to less than 35 kg pediatric weight bands, respectively. Temsavir relative bioavailability of 2 low‐dose fostemsavir extended‐release formulations (3 × 200 mg; formulations A and B) and reference formulation (600 mg extended release) was assessed in a 2‐part, open‐label, randomized, crossover study in healthy adults. Part 1 (N = 32) compared single‐dose temsavir relative bioavailability, and Part 2 (N = 16) evaluated the impact of fed versus fasted conditions using the selected low‐dose formulation. Temsavir geometric mean ratios for the area under the plasma concentration–time curve from time zero to infinity and maximum concentration for formulation B were bioequivalent to the reference formulation. Temsavir maximum concentration for formulation B was similar in fed and fasted states, but area under the plasma concentration–time curve from time zero to infinity geometric mean ratio was increased under fed conditions, consistent with previous results in adults. These analyses demonstrated efficient pediatric dose selection using a model‐based approach.
The genetics‐morphology‐behavior trifecta: Unraveling the single greatest limitation affecting our understanding of chondrichthyan evolution
Authors: Gayford Joel H. 
Published: June 2023

AbstractSharks, rays, and chimaera form the clade Chondrichthyes, an ancient group of morphologically and ecologically diverse vertebrates that has played an important role in our understanding of gnathostome evolution. Increasingly, studies seek to investigate evolutionary processes operating within the chondrichthyan crown group, with the broad aim of understanding the driving forces behind the vast phenotypic diversity observed among its constituent taxa. Genetic, morphological, and behavioral studies have all contributed to our understanding of phenotypic evolution yet are typically considered in isolation in the context of Chondrichthyes. In this viewpoint, I discuss why such isolation is prevalent in the literature, how it constrains our understanding of evolution, and how it might be overcome. I argue that integrating these core fields of organismal biology is vital if we are to understand the evolutionary processes operating in contemporary chondrichthyan taxa and how such processes have contributed to past phenotypic evolution. Despite this, the necessary tools to overcome this major limitation already exist and have been applied to other taxa.
A practical guide to collections‐based research on ecogeographic rules
Authors: Shelomi Matan , Meiri Shai 
Published: June 2023

AbstractEcogeographic research into how species' forms vary across space, time, and climate has taken on new urgency due to contemporary global climate change. Research using museum specimens and other records to study biological rules like Bergmann's, Allen's, and Gloger's Rules has a long history and continues to generate publications and robust scientific debates. Despite the prevalence and history of the field, however, no simple guide on how to carry out such work has ever been published. To lower the barriers of entry for new researchers, this review was created as a practical guide on how to perform ecogeographic research. The guide consolidates disparately published methodologies into a single, convenient document that reviews the history and present of the field of ecogeographic rule research, and describes how to generate appropriate hypotheses, design experiments, gather, and analyze biotic and geographic data, and interpret the results in an ecologically meaningful manner. The result is a semi‐standardized guide that enables scientists at all levels from any institution to carry out an investigation from start to finish on any biological rule, taxon, and location of their choice.
Application of electromagnetic tuned mass damper with flywheels for controlling building structure vibration
Authors: Lin Chih‐Shiuan , Lin Ging‐Long 
Published: June 2023

AbstractThis study investigates a novel electromagnetic tuned mass damper with flywheels (EM‐FW‐TMD) system for reducing building structure vibration. The EM‐FW‐TMD system comprises a tuned mass damper (TMD) system with an electromagnetic (EM) damper and flywheels (FW). The EM damping coefficient and inertance of the EM‐FW‐TMD are adjustable. A prototype EM‐FW‐TMD device is fabricated and tested to validate its adjustability. Sliding‐ and pendulum‐type EM‐FW‐TMD systems with various inerter configurations are investigated. The equations of motion for single‐ and multiple‐degree‐of‐freedom structures in which the two EM‐FW‐TMD systems are installed are derived. A parameter optimization method that considers inertance is proposed for the EM‐FW‐TMD systems. The control performance of the two EM‐FW‐TMD systems is extensively compared. Furthermore, for frequency detuning, a parameter redesign method is proposed for adjusting the inertance and EM damping coefficient of both types of EM‐FW‐TMD systems; the results indicate that the detuning effect can be significantly mitigated by this retuning method.
Adenine DNA methylation is involved in regulating ethanol and osmotic stress responses in Lacticaseibacillus paracasei Zhang
Authors: Yan Jiaming , Wu Meiling , Kwok Lai‐Yu , Zhang Wenyi 
Published: June 2023

AbstractAs an important feature of epigenetics, DNA methylation is a critical way to regulate gene expression and thus bacterial growth and metabolism. Lacticaseibacillus paracasei Zhang is a probiotic strain originated from koumiss. This study hypothesized that adenine methylation was involved in bacterial regulation of physiological adaptations when grown under environmental stress. Thus, this study compared the growth of an adenine methyltransferase‐inactivated mutant (ΔpglX) and the wild‐type L. paracasei Zhang when cultured under ethanol and osmotic stress. Transcriptomic and proteomic analyses were implemented to identify their differentially expressed genes/proteins (DEGs/DEPs) when grown under the stressed environments. The membrane fatty acid composition was also determined. Comparing with the wild‐type, the viable counts of the mutant under ethanol and osmotic stress increased by 2.6 times and decreased by half, respectively (ethanol stress: mutant, 4.30 ± 0.0038 × 108 CFU/mL; wild‐type, 1.64 ± 0.010 × 108 CFU/mL; osmotic stress: mutant, 2.21 ± 0.029 × 108 CFU/mL; wild‐type, 4.30 ± 0.13 × 108 CFU/mL). Common to both conditions, many identified DEGs and DEPs were involved in carbohydrate metabolism and fatty acid biosynthesis, generally, with more carbohydrate metabolism pathways but fewer fatty acid biosynthesis pathways, accompanied by increases in the membrane fatty acids. Our observations suggested that L. paracasei Zhang maximizes its energy metabolism by enhancing carbohydrate metabolism and improves its membrane strength via increasing the fatty acid content under environmental stress. This is the first report analyzing the epigenetic‐level stress responsive mechanism of L. paracasei Zhang, providing insights into methylation‐based regulation of bacterial adaptive responses.
Maturity impact on physicochemical composition and polyphenol properties of extra virgin olive oils obtained from Manzanilla, Arbequina, and Koroneiki varieties in Iran
Authors: Ghreishi Rad Seyed Amirreza , Jalili Maryam , Ansari Farzaneh , Rashidi Nodeh Hamid , Rashidi Ladan 
Published: June 2023

AbstractThis study investigated the physicochemical properties and polyphenol composition of extra virgin olive oils (EVOOs) extracted from three olive cultivars. The investigated cultivars were Arbequina, Koroneiki, and Manzanilla, grown in Olive Research Station in Rudbar county, Gilan province, Iran, at three ripening stages. Several parameters were analyzed, including peroxide and acidity values, unsaponifiable matter, oxidative stability, total aliphatic alcohols, fatty acids (FAs), sterols, and triacylglycerol composition. The results showed that as maturity increased, parameters such as oil content, acidity value, and iodine value, rise, while parameters including peroxide value, oxidative stability, aliphatic alcohols, and unsaponifiable matter decreased (p < .05). The saponification value was slightly reduced in the developing ripening process (p > .05). The MUFA/PUFA ratio and total sterol content declined during the olive ripening stages (p < .05). The triterpenes decreased in Arbequina and Koroneiki cultivars but increased in Manzanilla cultivar during the maturity stages. According to the data, oleuropein decreased while oleuropein aglycone, oxidized aldehyde, and hydroxylic form of oleuropein increased for all EVOOs during maturation. Apigenin, quercetin, ligstroside aglycone, aldehyde and hydroxylic form, ferulic acid, caffeic acid, and catechin decreased during the ripening of fruits (p < .05). The main triglycerides were triolein (OOO), palmitodiolein (POO), dioleolinolein (OOL), and palmitooleolinolein (PLO) in all EVOOs. In addition, the olive cultivar and harvesting date influence the physicochemical properties and polyphenol composition of EVOOs extracted from olive varieties grown in one region. In conclusion, the results can present helpful information to determine the optimum maturity stage for the investigated olive cultivars.
High‐pressure processing applied to sliced dry‐cured Iberian loin: Effect of category, company, and storage temperature
Authors: Carrapiso Ana Isabel , Tejerina David , García‐Torres Susana , Trejo Antonia , Martín Mateos Maria Jesus , Delgado‐Adámez Jonathan , García‐Parra Jesús Javier , Ramírez Maria Rosario 
Published: June 2023

AbstractThe main purpose of this study was to evaluate the effect of high‐pressure processing (HPP) and storage temperature on the microbial counts, the instrumental color, and the oxidation stability of sliced dry‐cured Iberian loin from two categories and two leading companies. 600 MPa for 8 min was sufficient to decrease all the microbial counts without affecting the color and the oxidation status, the effect being modulated by the loin category and company, whose effect on those variables was marked. However, the subsequent 90‐day storage softened the initial effect of HPP on microorganisms and allowed a significant effect of HPP to develop on color and oxidation. In addition, the coliform counts were higher after storage at 20°C than at 4°C, suggesting that refrigeration may be needed during long‐term storage to ensure loin safety.
Investigation of cryoprotectants‐treated surimi protein deterioration during chilled and frozen storage: Functional properties and kinetic modeling
Authors: Maghsoudi Leila , Moosavi‐Nasab Marzieh , Abedi Elahe , Maleki Shahrzad 
Published: June 2023

AbstractThe relative cryoprotective effects of flaxseed protein hydrolysate and pectin in comparison with conventional cryoprotectant (sucrose + sorbitol + sodium tripolyphosphates) on stabilization of proteins in surimi of Capoor (Cyprinus carpio) were investigated during freezing (−20°C for 4 months) and chilling storage (4°C for 10 days). Although pectin caused to improve water‐holding capacity (27.8%; 4°C and 21.5%; −20°C) on account of highly more inhibitory impact on the ice crystals growth, the protein denaturation may have occurred. It can be related to higher reduction in the amount of salt extractable protein (%) and the immeasurable value of thiol group in surimi formulation containing pectin compared with other cryoprotectants. The results of modeling surimi samples showed that salt extractable protein and sulfhydryl content were in good agreement with the first‐order reaction model at −20°C and second‐order kinetic model at 4°C. In comparison with other samples, samples treated with flaxseed protein showed the lowest reaction rate constant during chilled and frozen storage. The results confirmed that flaxseed protein with no sweetness and considerable caloric value had a cryoprotective effect similar to sucrose + sorbitol + polyphosphate and even better.
Diffractaic acid exhibits thioredoxin reductase 1 inhibition in lung cancer A549 cells
Authors: Günaydın Şükran , Sulukoğlu Emine Karaca , Kalın Şeyda Nur , Altay Ahmet , Budak Harun 
Published: June 2023

AbstractLung cancer is the leading cause of cancer‐related deaths all over the world. Therefore, it has gained importance in the development of new chemotherapeutic strategies to identify anticancer agents with low side effects, reliable, high anticancer potential, and specific to lung cancer cells. Thioredoxin reductase 1 (TrxR1) is an important therapeutic target for lung cancer treatment because of its overexpression in tumor cells. Here, we aimed to examine the anticancer effect of diffractaic acid, a lichen secondary metabolite, in A549 cells by comparing it with the commercial chemotherapeutic drug carboplatin and also to investigate whether the anticancer effect of diffractaic acid occurs via TrxR1‐targeting. The IC50 value of diffractaic acid on A549 cells was determined as 46.37 μg/mL at 48 h, and diffractaic acid had stronger cytotoxicity than carboplatin in A549 cells. qPCR results revealed that diffractaic acid promoted the intrinsic apoptotic pathway through the upregulation of the BAX/BCL2 ratio and P53 gene in A549 cells, which is consistent with the flow cytometry results. Furthermore, migration analysis results indicated that diffractaic acid impressively suppressed the migration of A549 cells. While the enzymatic activity of TrxR1 was inhibited by diffractaic acid in A549 cells, no changes were seen in the quantitative expression levels of gene and protein. These findings provide fundamental data on the anticancer effect of diffractaic acid on A549 cells targeting TrxR1 activity, suggesting that it could be considered a chemotherapeutic agent for lung cancer therapy.
Selective determination of Cr(III) ions with novel potentiometric electrodes
Authors: Isildak Ömer , Özbek Oguz , Yildiz Ilyas , Senocak Aysegül 
Published: June 2023

AbstractBackgroundIonophores in the composition of potentiometric ion‐selective electrodes interact directly with the analyte ion and enable the determination of ionic species in various samples.ObjectivesIn this study, a novel ion‐selective electrode based on 5‐bromosalicylaldehyde thiosemicarbazone was developed for the selective determination of Cr3+ ions.MethodsThe optimum electrode composition contained ionophore, poly (vinyl chloride) (PVC), bis (2‐ethylhexyl) sebacate (BEHS) and potassium tetrakis (p‐chlorophenyl) borate (KTpClPB) in ratios of 4.0: 61.0: 34.0: 1.0 (mg), respectively. Potential measurements were performed using a computer‐controlled multi‐channel potentiometric measurement system.ResultsThe developed Cr (III)‐selective electrode exhibited a low detection limit of 3.96 × 10−6 M over a wide concentration range of 1.0 × 10−5 – 1.0 × 10−1 M (R2: 0.9979). The electrode exhibited good selectivity towards Cr3+ ions among metal ions with different charges. The chromium (III)‐selective electrode, which exhibited highly reproducible results in three different concentration ranges, also had a very fast response time of 5 s.ConclusionsThe developed Cr (III)‐selective electrode were successfully performed in various beverage samples. As a result, the proposed electrode can be an alternative to other analytical methods in the analysis of Cr3+ ions.
Assessing craniofacial growth and form without landmarks: A new automatic approach based on spectral methods
Authors: Magnet Robin , Bloch Kevin , Taverne Maxime , Melzi Simone , Geoffroy Maya , Khonsari Roman H. , Ovsjanikov Maks 
Published: June 2023

AbstractWe present a novel method for the morphometric analysis of series of 3D shapes, and demonstrate its relevance for the detection and quantification of two craniofacial anomalies: trigonocephaly and metopic ridges, using CT‐scans of young children. Our approach is fully automatic, and does not rely on manual landmark placement and annotations. Our approach furthermore allows to differentiate shape classes, enabling successful differential diagnosis between trigonocephaly and metopic ridges, two related conditions characterized by triangular foreheads. These results were obtained using recent developments in automatic nonrigid 3D shape correspondence methods and specifically spectral approaches based on the functional map framework. Our method can capture local changes in geometric structure, in contrast to methods based, for instance, on global shape descriptors. As such, our approach allows to perform automatic shape classification and provides visual feedback on shape regions associated with different classes of deformations. The flexibility and generality of our approach paves the way for the application of spectral methods in quantitative medicine.