bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bestimmungsfaktoren für landwirtschaftliche Bewässerungsbedarfe und regionale Governance-Ansätze zur Konfliktreduktion in Niedersachsen und Sachsen-Anhalt
Authors: Schulz Elisabeth , Scharun Christina 
Published: May 2023

ZusammenfassungZunehmende Trockenheit erhöht landwirtschaftliche Bewässerungsbedarfe. Erstmalige Grundwasserentnahmeanträge sowie Erweiterungsanträge nehmen zu. Damit verändern sich langjährige Gleichgewichte unter den Grundwassernutzern (Trinkwassergewinnung, Ökosystemschutz, Gewässerunterhaltung, Forstwirtschaft, Landwirtschaft, Verwaltung, Öffentlichkeit). Widerstände gegen Behördenentscheidungen könnten anwachsen. Um diesbezüglich potenzielle ressourcenzehrende Reibungsverluste zu verringern und stattdessen kooperatives Handeln anzustoßen, erprobten Landwirtschaftskammer Niedersachen und Landesamt für Bergbau, Energie und Geologie mit ausgewählten Landkreisen in zwei Projekten (Netzwerke Wasser) neuartige governance-basierte Handlungsansätze. Runde Tische mit Stakeholdervertretern wurden eingerichtet zwecks Kennenlernens, Kompetenzerweiterung und Vertrauensbildung. Während ganztägiger „Netzwerktreffen“ wurden regionalspezifische Fachinformationen einschließlich der Bestimmungsfaktoren für landwirtschaftliche Wassernachfrage vermittelt. Insbesondere fehlten objektive Informationen über aktuelle sowie zukünftige landwirtschaftliche Bewässerungsbedarfe. Deshalb wurden die örtlichen potenziellen Beregnungsbedürftigkeiten auf Basis hochaufgelöster Bodendaten, Ackerkulturartenanteilen und Klima(projektions)daten ermittelt. Eindeutige Trends zu steigenden potenziellen Beregnungsbedarfen von bis zu 31 % im Gebietsmittel bis Jahrhundertende wurden festgestellt. Besonders wichtig waren die Möglichkeiten für informellen Austausch der Handelnden. Abschließend überwog deutlich der Wunsch nach Verstetigung der Stakeholder-Plattformen.
Trends and issues in clinical research on satisfaction and quality of life after mastectomy and breast reconstruction: a 5-year scoping review
Authors: Saiga Miho , Nakagiri Ryoko , Mukai Yuko , Matsumoto Hiroshi , Kimata Yoshihiro 
Published: May 2023

AbstractBreast reconstruction (BR) aims to improve the satisfaction and quality of life (QOL) of breast cancer survivors. Clinical studies using patient-reported outcomes (PROs) can therefore provide relevant information to the patients and support decision-making. This scoping review was conducted to analyze recent trends in world regions, methods used, and factors investigated. The literature search was conducted in August 2022. Databases of PubMed, MEDLINE, and CINAHL were searched for relevant English-language studies published from 2017 to 2022. Studies involving women with breast cancer who underwent BR after mastectomy and investigated PROs after BR using BR-specific scales were included. Data on the country, publication year, study design, PRO measures (PROMs) used, time points of surveys, and research themes were collected. In total, 147 articles met the inclusion criteria. BREAST-Q was the most widely used, contributing to the increase in the number and diversification of studies in this area. Such research has been conducted mainly in North America and Europe and is still developing in Asia and other regions. The research themes involved a wide range of clinical and patient factors in addition to surgery, which could be influenced by research methods, time since surgery, and even cultural differences. Recent BR-specific PROMs have led to a worldwide development of research on factors that affect satisfaction and QOL after BR. PRO after BR may be influenced by local cultural and social features, and it would be necessary to accumulate data in each region to draw clinically useful conclusion.
Automated microparticle positioning using a pair of ultrasound-actuated microbubbles for microfluidic applications
Authors: Bakhtiari Amirabas , Kähler Christian J. 
Published: May 2023

AbstractWe present an advanced single-particle positioning technique that uses ultrasound-driven microstreaming induced by two microbubbles to position microparticles across the width of a microchannel or to direct them to desired exits of a Y-shaped microchannel. An open-loop control algorithm has been devised to facilitate the automatic detection, tracking, and precise positioning of microparticles in the presence of two microbubbles. Our control system is capable of performing particle positioning in multiple steps, individually for each microparticle, with arbitrary starting positions without requiring prior particle focusing or flow conditioning. We have also evaluated the accuracy enhancement of particle positioning using two microbubbles, in comparison to the system’s results using only one microbubble.
Premenopausal women with breast cancer in the early post-partum period show molecular profiles of invasion and are associated with poor prognosis
Authors: Nimbalkar Vidya P. , Snijesh V. P. , Rajarajan Savitha , Alexander Annie , Kaluve Rohini , Ramesh Rakesh , Srinath B. S. , Prabhu Jyothi S. 
Published: May 2023

Abstract
Purpose
Young premenopausal women develop breast cancer (BC) within 5–10 years of the last childbirth, known as post-partum breast cancers (PPBC), often present with aggressive disease. The exact mechanisms that lead to poor prognosis in these patients are largely unknown.

Methods
We have evaluated the association of clinical and reproductive factors with BC in a cohort of women ≤ 45 years (N = 155) with long-term follow-up. Based on duration since last childbirth (LCB), grouped patients into PPBC1 (LCB ≤ 5 years), PPBC2 (LCB between 6 and 10 years), PPBC3 (LCB > 10 years), and NPBC (age-matched nulliparous BC patients). We compared disease-free survival and hazard associated with recurrence/metastasis between the groups. RNA sequencing of tumor samples was performed from three parous groups (n = 10), and transcriptomic data were analyzed for differentially expressed genes and altered pathways.

Results
Women in the PPBC1 group had an early menarche and late age at first and last childbirth compared to other groups. Survival analysis within lymph node-positive tumors showed that PPBC1 tumors had a worse prognosis than PPBC2 and NPBC tumors (p = 0.015 and p = 0.026, respectively). Clustering of the differentially expressed genes between the groups showed distinct expression in early PPBC (E-PPBC) tumors. Pathway analysis revealed upregulation of invasive-related pathways along with T cell exhaustion, extracellular matrix remodeling, angiogenesis, and epithelial-to-mesenchymal transition in E-PPBC tumors.

Conclusion
Early PPBC is a unique subtype with aggressive clinical features and distinct biology. Further research is needed to accurately project the risk of recurrence and optimal treatment strategies in these young patients.
Integrating Motivation and Instruction: Towards a Unified Approach in Educational Psychology
Authors: Martin Andrew J. 
Published: May 2023

AbstractMotivation and instruction are two major substantive domains in educational psychology. Theory and research relevant to each of these domains tend to be diffuse and fragmented. This presents challenges for scholars and practitioners seeking to implement parsimonious and cohesive approaches to help students to learn. This review articulates a two-step integration process that is an illustrative effort towards tackling these challenges and unifying two psycho-educational domains:intra-domain integration (within each of motivation and instruction) andinter-domain integration (between motivation and instruction). With respect to motivation, the Motivation and Engagement Wheel (Martin, 2007) is presented as an example ofintra-domain integration of key facets of motivation (Step 1a). With respect to instruction, Load Reduction Instruction (LRI; Martin, 2016; Martin & Evans, 2018) is an example ofintra-domain integration of explicit instruction and guided independent learning (Step 1b). The review then proposes aninter-domain integration of motivation and instruction (Step 2), arguing that each domain is tied to the other. The joint operation ofintra- andinter-domain integration of motivation and instruction holds potential for more coherent theorizing, measurement, and practical application.
Assessment of Hg pollution in stream waters and human health risk in areas impacted by mining activities in the Ecuadorian Amazon
Authors: Mestanza-Ramón Carlos , Jiménez-Oyola Samantha , Montoya Alex Vinicio Gavilanes , Vizuete Danny Daniel Castillo , D’Orio Giovanni , Cedeño-Laje Juan , Straface Salvatore 
Published: May 2023

AbstractIllegal gold mining activities have contributed to the release and mobilization of Hg and environmental degradation in many parts of the world. This study aims to determine the concentration of Hg in five provinces of the Amazon Region of Ecuador, in addition to assessing the risk to human health of exposed populations, applying deterministic and probabilistic methods. For this purpose, 147 water samples were collected in rivers and streams crossing and/or located near mining areas. As a result, 100% of the samples analyzed exceeded the maximum permissible limit (MPL) according to the water quality criteria for the preservation of aquatic life of the Ecuadorian regulations, while 7% of the samples exceeded the MPL for drinking water. On the other hand, considering the European Environmental Quality Standard (EQS) for surface water bodies, in our study, 100% of the samples exceed the maximum permissible limit (0.07 µg/L), and with respect to the Canadian water quality guidelines, 35% of the samples exceed the permissible limit (0.001 mg/l) for drinking water, and 100% of the samples exceed the limit for life in water bodies (0.0001 mg/l). The risk assessment revealed that the probability of developing adverse health effects from exposure to Hg is below the recommended limits according to the probabilistic assessment; this is in relation to the criterion of residential and recreational use of water resources. However, it was identified that the child population doubles the acceptable systemic risk level according to the results of the deterministic assessment in the residential scenario. This information can be used by decision-makers to implement strategies to reduce Hg contamination and exposure of the population in Ecuadorian Amazonian rivers.
Performance analysis of English hospitals during the first and second waves of the coronavirus pandemic
Authors: Kuosmanen Timo , Tan Yong , Dai Sheng 
Published: May 2023

AbstractThe coronavirus infection COVID-19 killed millions of people around the world in 2019-2022. Hospitals were in the forefront in the battle against the pandemic. This paper proposes a novel approach to assess the effectiveness of hospitals in saving lives. We empirically estimate the production function of COVID-19 deaths among hospital inpatients, applying Heckman’s two-stage approach to correct for the bias caused by a large number of zero-valued observations. We subsequently assess performance of hospitals based on regression residuals, incorporating contextual variables to convex quantile regression. Data of 187 hospitals in England over a 35-week period from April to December 2020 is divided in two sub-periods to compare the structural differences between the first and second waves of the pandemic. The results indicate significant performance improvement during the first wave, however, learning by doing was offset by the new mutated virus straits during the second wave. While the elderly patients were at significantly higher risk during the first wave, their expected mortality rate did not significantly differ from that of the general population during the second wave. Our most important empirical finding concerns large and systematic performance differences between individual hospitals: larger units proved more effective in saving lives, and hospitals in London had a lower mortality rate than the national average.
A Characterization of Van Hiele’s Level 5 of Geometric Reasoning Using the Delphi Methodology
Authors: Arnal-Bailera Alberto , Manero Víctor 
Published: May 2023

AbstractThe Van Hiele model of geometric reasoning establishes five levels of development, from level 1 (visual) to level 5 (rigor). Despite the fact that this model has been deeply studied, there are few research works concerning the fifth level. However, there are some works that point out the interest of working with activities at this level to promote the acquisition of previous levels. Our goal is to describe this level through the construction and validation of a list of indicators for each of the processes involved in geometrical reasoning (definition, proof, classification, and identification). Due to the lack of previous research, we have decided to use the Delphi methodology. This approach allowed us to collect information from a panel of experts to reach a consensus through a series of phases about the indicators that describe each of the processes. The final product of the iterative application of this method is a list of validated indicators of the fifth Van Hiele level of reasoning. In particular, proof and definition processes have turned out to be the most relevant processes at this level.
Service Re-Selection for Disruptive Events in Mobile Environments: A Heuristic Technique for Decision Support at Runtime
Authors: Bortlik Michael , Heinrich Bernd , Lohninger Daniel 
Published: May 2023

AbstractModern service-based processes in mobile environments are highly complex due to the necessary spatial–temporal coordination between multiple participating users and the consideration of context information. Due to the dynamic nature of mobile environments, disruptive events occur at runtime, which require a re-selection of the planned service compositions respecting multiple users and context-awareness. Thereby, when re-selecting services the features performance, solution quality, solution robustness and alternative solutions are essential and contribute to the efficacy of service systems. This paper presents an optimization-based heuristic technique based on a stateful representation that uses a region-based approach to re-select services considering multiple users, context information and in particular disruptive events at runtime. The evaluation results, which are based on a real-world scenario from the tourism domain, show that the proposed heuristic is superior compared to competing artifacts.
Subcutaneous Immunoglobulin 16.5% (Cutaquig®) in Primary Immunodeficiency Disease: Safety, Tolerability, Efficacy, and Patient Experience with Enhanced Infusion Regimens
Authors: Gupta Sudhir , DeAngelo James , Melamed Isaac , Walter Jolan E. , Kobayashi Ai-Lan , Bridges Tracy , Sublett J. Wesley , Bernstein Jonathan A. , Koterba Alan , Manning Michael , Maltese Joanna , Hoeller Sonja , Turpel-Kantor Eva , Kreuwel Huub , Kobayashi Roger H. 
Published: May 2023

Abstract
Purpose
To achieve reductions in infusion time, infusion sites, and frequency, a prospective, open-label, multicenter, Phase 3 study evaluated the safety, efficacy, and tolerability of subcutaneous immunoglobulin (SCIG) 16.5% (Cutaquig®, Octapharma) at enhanced infusion regimens.

Methods
Three separate cohorts received SCIG 16.5% evaluating volume, rate, and frequency: Cohort 1) volume assessment/site: up to a maximum 100 mL/site; Cohort 2) infusion flow rate/site: up to a maximum of 100 mL/hr/site or the maximum flow rate achievable by the tubing; Cohort 3) infusion frequency: every other week at twice the patient’s weekly dose.

Results
For Cohort 1 (n = 15), the maximum realized volume per site was 108 mL/site, exceeding the currently labeled (US) maximum (up to 40 mL/site for adults). In Cohort 2 (n = 15), the maximum realized infusion flow rate was 67.5 mL/hr/site which is also higher than the labeled (US) maximum (up to 52 mL/hr/site). In Cohort 3 (n = 34), the mean total trough levels for every other week dosing demonstrated equivalency to weekly dosing (p value = 0.0017). All regimens were well tolerated. There were no serious bacterial infections (SBIs). Most patients had mild (23.4%) or moderate (56.3%) adverse events. The majority of patients found the new infusion regimens to be better or somewhat better than their previous regimens and reported that switching to SCIG 16.5% was easy.

Conclusions
SCIG 16.5% (Cutaquig®), infusions are efficacious, safe, and well tolerated with reduced infusion time, fewer infusion sites, and reduced frequency. Further, the majority of patients found the new infusion regimens to be better or somewhat better than their previous regimens.
Fungal Keratitis Caused by Talaromyces coalescens: A Case Report
Authors: Todokoro Daisuke , Miyakubo Tomoko , Makimura Koichi , Tamura Takashi , Komori Aya , Akiyama Hideo 
Published: May 2023

AbstractFungal keratitis is a severe corneal infection, and the causative fungi include various rare fungal species. Fungal keratitis caused by Talaromyces species has yet to be reported, and there is no information about this fungus as a cause of keratitis. A 77-year-old man developed fungal keratitis while waiting for a donor cornea due to bullous keratopathy in his left eye. Fungal culture of a corneal scraping grew filamentous fungi, which were morphologically identified as Paecilomyces species. The corneal infection did not improve after topical administration of 1% voriconazole, and ribosomal DNA sequencing definitively verified the fungus to be Talaromyces coalescens. The lesion gradually improved after switching to topical 5% natamycin. Antifungal susceptibility tests determined the high minimum inhibitory concentrations of voriconazole to be > 8 μg/mL. This is the first report of Talaromyces fungal keratitis. Clinicians, especially those in ophthalmology, need to be aware of this rare fungus.
Using Concept Mapping to Explore the Perspectives of People with Mild to Borderline Intellectual Disabilities Toward Sexual Health
Authors: de Wit Wouter , Roeg Diana , Embregts Petri J. C. M. 
Published: May 2023

AbstractPeople with mild to borderline intellectual disabilities face many barriers toward their sexual health. To promote sexual health and overcome these barriers, they need individualized forms of sexuality support and education. To align sexuality support and education insight is needed on their understanding of sexual health. The current paper aims to provide greater insight in what sexual health consists of according to people with mild to borderline intellectual disabilities. Nine people with a mild to borderline intellectual disability participated in a concept mapping procedure, consisting of brainstorming, sorting, and ranking the statements. The resulting clusters and concept map were interpreted by an expert group. Analysis resulted in five clusters which participants considered important for their sexual health. According to people with mild to borderline intellectual disability cluster pertaining to romantic relationships and sexual socialization were the most important. These were followed by clusters on sexual health and lastly sexual selfhood. These results have implications for the development of sexuality support and education, as well as further research.
Adaptive online variance estimation in particle filters: the ALVar estimator
Authors: Mastrototaro Alessandro , Olsson Jimmy 
Published: May 2023

AbstractWe present a new approach—the estimator—to estimation of asymptotic variance in sequential Monte Carlo methods, or, particle filters. The method, which adjusts adaptively the lag of the estimator proposed in Olsson and Douc (Bernoulli 25(2):1504–1535) applies to very general distribution flows and particle filters, including auxiliary particle filters with adaptive resampling. The algorithm operates entirely online, in the sense that it is able to monitor the variance of the particle filter in real time and with, on the average, constant computational complexity and memory requirements per iteration. Crucially, it does not require the calibration of any algorithmic parameter. Estimating the variance only on the basis of the genealogy of the propagated particle cloud, without additional simulations, the routine requires only minor code additions to the underlying particle algorithm. Finally, we prove that the estimator is consistent for the true asymptotic variance as the number of particles tends to infinity and illustrate numerically its superiority to existing approaches.
ADELA: a conversational virtual assistant to prevent delirium in hospitalized older persons
Authors: Alonso-Mencía Javier , Castro-Rodríguez Marta , Herrero-Pinilla Beatriz , Alonso-Weber Juan M. , Rodríguez-Mañas Leocadio , Pérez-Rodríguez Rodrigo 
Published: May 2023

AbstractDelirium is a sudden mental state that causes confusion and disorientation, affecting a person's ability to think and remember clearly. Virtual assistants are a promising alternative for non-pharmacological interventions. This research aims to present a prototype of ADELA, a conversational assistant to prevent delirium in hospitalized older persons who speak Spanish. A co-creation process with medical experts to identify requirements was carried out to later develop the assistant iteratively and evaluate it from a technical and usability perspectives; the latest using the Spanish version of the System Usability Scale (SUS) and the Chatbot Usability Questionnaire (CUQ), supplemented by qualitative data. Mean values of 75.5 and 85.94 were obtained for SUS and CUQ, respectively. The technical evaluation helped defining the minimum environmental specifications required for deployment. Obtained results imply the assistant is usable and potentially accepted by the target population; useful information was extracted for refinement. Technical evaluation showed positive results, indicating it can be used in a real clinical environment.
Droplet Formation, Growth and Detachment at the Interface of a Coupled Free-FLow–Porous Medium System: A New Model Development and Comparison
Authors: Veyskarami Maziar , Michalkowski Cynthia , Bringedal Carina , Helmig Rainer 
Published: May 2023

AbstractCoupled free-flow–porous medium systems are of great importance in various natural and industrial applications. Modeling of such systems is always challenging, especially when droplets form at the interface between the two domains. We propose a new concept to take droplet formation, growth and detachment at the interface into account. In this concept, we use pore-network modeling to describe the porous medium and the Navier–Stokes equations for the free-flow domain. New coupling conditions are developed which include droplet interactions with the free flow and the porous medium. Impacts of using different descriptions of the forces acting on the triple contact line and contact angle hysteresis on the predicted onset of the droplet detachment are examined. In addition, we compare the new approach with another model built using ANSYS Fluent based on the volume of fluid method. The results show that the new model is able to describe the droplet formation, growth and then detachment by the free flow. The proposed model provides a base for further developments to handle formation of multiple droplets at the interface between a free flow and a porous medium as well as to include the evaporation in future works.