bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol attenuates chronic social isolation stress‐induced affective disorders: Involvement of NF‐κB/NLRP3 axis
Authors: Zarebavani Mitra , Baghaei Naeini Farinaz , Farahvash Amirali , Moradi Fatemeh , Dashti Nasrin 
Published: January 2023

AbstractSocial isolation stress (SIS) is associated with affective disorders (i.e., anxiety and depression) in adults. In a preclinical study, we aimed to investigate the effects of resveratrol (RV) on the mood swings of rats exposed to SIS. Animals were randomized into six different groups, including control: healthy animals received normal saline (NS) as a vehicle; SIS + NS: SIS animals received NS; SIS + FL: SIS animals received fluoxetine (10 mg/kg/i.p.); SIS + RV20, SIS + RV40, and SIS + RV80: SIS animals received RV (20, 40, and 80 mg/kg/i.p). SIS was induced for 4 weeks, then animals were treated with NS, FL, and RV for 4 weeks. Rats were evaluated by the behavioral tests, including the elevated plus‐maze, tail suspension test, the open field test, and forced‐swimming test, for mood alterations and nuclear factor kappa B (NF‐κB) levels, along with NLRP3, apoptosis‐associated speck‐like (ASC), and proCaspase‐1 were determined in the hippocampus. Behavioral tests confirmed that exposing the animals to SIS caused anxiety and depression. The highest concentrations of NLRP3, proCaspase‐1, ASC, and NF‐κB, were confirmed in the SIS + NS group. Compared to FL, RV showed antidepressant potential according to the behavioral tests. In particular, the administration of RV (20, 40, and 80 mg/kg) revered the NF‐κB/NLRP3 axis cascade in rats exposed to chronic SIS. Our findings revealed that RV attenuated anxiety and depression of SIS‐exposed rats via regulation of NF‐κB/NLRP3 signaling pathways. RV can be used as a potential anxiolytic agent and antidepressant.
Concomitant pharmacologic medications influence the clinical outcomes of granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis: A multicenter retrospective cohort study
Authors: Ueno Nobuhiro , Sugiyama Yuya , Kobayashi Yu , Murakami Yuki , Iwama Takuya , Sasaki Takahiro , Kunogi Takehito , Sakatani Aki , Takahashi Keitaro , Tanaka Kazuyuki , Serikawa Shinya , Ando Katsuyoshi , Kashima Shin , Muto Momotaro , Inaba Yuhei , Moriichi Kentaro , Tanabe Hiroki , Okumura Toshikatsu , Fujiya Mikihiro 
Published: January 2023

AbstractBackgroundGranulocyte and monocyte adsorptive apheresis (GMA) with Adacolumn has been used as a remission induction therapy for patients with active ulcerative colitis (UC). Herein, we investigated the influence of concomitant medications in the remission induction of GMA in patients with active UC.MethodsThis multicenter retrospective cohort study included patients with UC underwent GMA in five independent institutions in Japan from January 2011 to July 2021. Factors including concomitant medications associated with clinical remission (CR) were analyzed statistically.ResultA total of 133 patients were included. Seventy‐four patients achieved a CR after GMA. The multivariable analysis revealed that concomitant medication with 5‐aminosalicylic acid, Mayo endoscopic subscore (MES), and concomitant medication with immunosuppressors (IMs) remained as predictors of CR after GMA. In the subgroup analysis in patients with MES of 2, concomitant medication with IMs was demonstrated as a significant negative factor of CR after GMA (P = .042, OR 0.354). Seventy‐four patients who achieved CR after GMA were followed up for 52 weeks. In the multivariable analysis, the maintenance therapy with IMs was demonstrated as a significant positive factor of sustained CR up to 52 weeks (P = .038, OR 2.214). Furthermore, the rate of sustained CR in patients with biologics and IMs was significantly higher than that in patients with biologics only (P = .002).ConclusionGMA was more effective for patients with active UC that relapsed under treatment without IMs. Furthermore, the addition of IMs should be considered in patients on maintenance therapy with biologics after GMA.
Soaring rates of alcohol‐related hepatitis in the latter phase of the COVID‐19 pandemic: A new normal?
Authors: Sohal Aalam , Khalid Sameeha , Green Victoria , Hagino Jeffrey , Chaudhry Hunza , Gulati Alakh , Roytman Marina 
Published: January 2023

AbstractBackgroundStudies have reported that the COVID‐19 pandemic has led to an increase in alcohol consumption and alcohol‐associated health problems in the general population. Our previous study documented a rise in severe alcohol‐related hepatitis cases requiring inpatient admission in our hospital system in the early pandemic (2019 vs. 2020). This study assesses the rates of severe alcohol‐related hepatitis in the latter part of the pandemic (2021).MethodsWe performed a retrospective chart review via an electronic medical record to evaluate the number of cases of alcohol‐related hepatitis in patients presenting to three community hospitals in Fresno, California, between 2019 (pre‐pandemic) and 2021. A total of 547 patients were included in the study. We compared the demographics, clinical course, and outcomes of patients with alcohol‐related hepatitis pre‐pandemic (2019), early pandemic (2020), and during the later phase of the pandemic (2021).ResultsThe number of cases increased from 131 in 2019 to 201 in 2020 and 215 in 2021 (53% and 64% increase, respectively). The number of young patients (age <40 years) increased from 30 in 2019 to 61 in 2020 and 71 in 2021 (103% and 136% increase, respectively) (p = 0.13). The number of admissions of women increased from 24 in 2019 to 55 in 2020 and 67 in 2021 (129% and 179% increase, respectively) (p = 0.026). Deaths during hospitalization increased from 20 in 2019 to 26 in 2021 (p = 0.674). The number of rehospitalizations within 3 months increased 4.5 times from 18 in 2019 to 80 in 2021 (p < 0.001).ConclusionOur study revealed that the admissions for alcohol‐related hepatitis remained significantly above the pre‐pandemic levels through the end of 2021. We believe this sustained increase in cases of alcohol‐related hepatitis in our hospital system reflects a much larger national problem. Alcohol‐related hepatitis is associated with significant morbidity, mortality, and societal cost. Urgent public health interventions are needed at a national level to prevent this rise in cases from becoming a new normal.
Lower bounds on the Erdős–Gyárfás problem via color energy graphs
Authors: Balogh József , English Sean , Heath Emily , Krueger Robert A. 
Published: January 2023

AbstractGiven positive integers and , a ‐coloring of the complete graph is an edge‐coloring in which every ‐clique receives at least colors. Erdős and Shelah posed the question of determining , the minimum number of colors needed for a ‐coloring of . In this paper, we expand on the color energy technique introduced by Pohoata and Sheffer to prove new lower bounds on this function, making explicit the connection between bounds on extremal numbers and . Using results on the extremal numbers of subdivided complete graphs, theta graphs, and subdivided complete bipartite graphs, we generalize results of Fish, Pohoata, and Sheffer, giving the first nontrivial lower bounds on for some pairs and improving previous lower bounds for other pairs.
Shifted excitation Raman difference spectroscopy for soil component identification and soil carbonate determination in the presence of strong fluorescence interference
Authors: Sowoidnich Kay , Maiwald Martin , Ostermann Markus , Sumpf Bernd 
Published: January 2023

AbstractDetailed knowledge about soil composition is an important prerequisite for many applications, for example precision agriculture. Current standard laboratory methods are complex and time‐consuming but could be complemented by non‐invasive optical techniques. Its capability to provide a molecular fingerprint of individual soil components makes Raman spectroscopy a very promising candidate. A major challenge is strong fluorescence interference inherent to soil, but this issue can be overcome effectively using shifted excitation Raman difference spectroscopy (SERDS). A customized dual‐wavelength diode laser emitting at 785.2 and 784.6 nm was used to investigate 117 soil samples collected from an agricultural field along a distance of 624 m and down to depths of 1 m. To address soil spatial heterogeneity, a raster scan approach comprising 100 measurement spots per sample was applied. Based on the Raman spectroscopic fingerprint extracted from intense fluorescence interference by SERDS, 13 mineral soil constituents were identified, and even closely related molecular species could be discriminated, for example polymorphs of titanium dioxide and calcium carbonate. For the first time, the capability of SERDS is demonstrated to predict the calcium carbonate content as an important soil parameter using partial least squares regression (R2 = 0.94, root mean square error of cross‐validation RMSECV = 2.1%). Our findings demonstrate that SERDS can extract a wealth of spectroscopic information from disturbing backgrounds enabling qualitative and quantitative soil analysis. This highlights the large potential of SERDS for precision agriculture but also in further application areas, for example geology, cultural heritage and planetary exploration.
Use of Sound Touch Elastography and Sound Touch Quantification for the Noninvasive Evaluation of Portal Hypertension in a Rat Model
Authors: Dong Bingtian , Lyu Guorong , Wang Huaming , Chen Yongjian , Wei Kaipeng 
Published: January 2023

ObjectivesIn this study, we used the recently developed ultrasound elastography techniques sound touch elastography (STE) and sound touch quantification (STQ) to quantify portal hypertension (PHT) severity in a rat model of carbon tetrachloride (CCl4)‐induced cirrhotic PHT.MethodsIn total, 60 rats were used. Various degrees of PHT were established. Liver and spleen stiffness were measured by STE (L‐STE and S‐STE, respectively) and STQ (L‐STQ and S‐STQ, respectively). We measured portal pressure (PP) after ultrasonographic examination. The performance of the STE and STQ parameters in the identification of PHT was evaluated using receiver operating characteristic (ROC) analyses.ResultsLiver and spleen stiffness measurements obtained with STE and STQ correlated positively with the PP (r = 0.566–0.882, all P < .001). The areas under ROC curves for L‐STE, S‐STE, L‐STQ, and S‐STQ values were 0.931 (95% confidence interval [CI], 0.847–1.000), 0.982 (95% CI, 0.956–1.000), 0.796 (95% CI, 0.680–0.912), and 0.925 (95% CI, 0.858–0.993), respectively, for PP ≥5 mmHg; 0.937 (95% CI, 0.865–1.000), 0.938 (95% CI, 0.864–1.000), 0.967 (95% CI, 0.923–1.000), and 0.960 (95% CI, 0.897–1.000), respectively, for PP ≥10 mmHg; and 0.954 (95% CI, 0.897–1.000), 0.790 (95% CI, 0.652–0.928), 0.808 (95% CI, 0.680–0.935), and 0.740 (95% CI, 0.595–0.885), respectively, for PP ≥12 mmHg.ConclusionsSTE and STQ are reliable noninvasive tools for the assessment of PHT severity, especially for PP ≥10 mmHg, in a rat model of CCl4‐induced cirrhotic PHT.
Capturing of organic carbon and nitrogen in eelgrass sediments of southern Scandinavia
Authors: Leiva‐Dueñas Carmen , Graversen Anna Elizabeth Løvgren , Banta Gary T. , Holmer Marianne , Masque Pere , Stæhr Peter Anton Upadhyay , Krause‐Jensen Dorte 
Published: January 2023

AbstractThe ability of seagrass meadows to filter nutrients and capture and store CO2 and nutrients in the form of organic carbon (OC) and nitrogen (N) in their sediments may help to mitigate local eutrophication as well as climate change via meadow restoration and protection. This study assesses OC and N sediment stocks (top 50 cm) and sequestration rates within Danish eelgrass meadows. At four locations, eelgrass‐vegetated and nearby unvegetated plots were studied in protected and exposed areas. The average OC and N sediment 50 cm stocks were 2.6 ± 0.3 kg OC m−2 and 0.23 ± 0.01 kg N m−2, including vegetated and unvegetated plots. In general, OC and N stocks did not differ significantly between eelgrass meadows and unvegetated sediments. Lack of accumulation of excess 210Pb suggested sediment erosion or low rates of sediment accumulation at most sites. OC accumulation rates ranged from 6 to 134 g m−2 yr−1 and N from 0.7 to 14 g m−2 yr−1. Generalized additive models showed that ≥ 80% of the variation in sediment OC and N stocks was explained by sediment grain size, organic matter source, and hydrodynamic exposure. Long cores, dated with 210Pb, showed declining OC and N densities toward present time, suggesting long‐term declines in eelgrass OC and N pools. Estimates of potential nation‐wide OC and N accumulation in eelgrass sediments show that they could annually capture up to 0.7% ± 0.5% of CO2 emissions and 6.9% ± 5.2% of the total terrestrial N load.
Price competition and joint energy‐consumption reduction technology investment of new energy and fuel vehicles under the double‐points policy
Authors: Wang Yangyang , Yi Yongxi , Fu Chunyan , Li Yuqiong 
Published: January 2023

AbstractThis paper explores for the first time the manufacturers' joint energy reduction strategies for both new energy and fuel vehicles. Assume there is a Cournot car market with differentiated products consisting of one manufacturer producing fuel cars and one manufacturer producing fuel and new energy cars, and a double‐points policy governs them. It shows that the double‐points policy does not necessarily result in a contraction in the fuel vehicle market while leading to a boom in the new energy vehicle market; market competition and consumers' preference for low energy consumption can help incentive manufacturers to reduce vehicle energy consumption.
Global sensitivity study for irreversible electroporation: Towards treatment planning under uncertainty
Authors: Lakshmi Narasimhan Prashanth , Tokoutsi Zoi , Baroli Davide , Baragona Marco , Veroy Karen , Maessen Ralph , Ritter Andreas 
Published: January 2023

AbstractBackgroundElectroporation‐based cancer treatments are minimally invasive, nonthermal interventional techniques that leverage cell permeabilization to ablate the target tumor. However, the amount of permeabilization is susceptible to the numerous uncertainties during treatment, such as patient‐specific variations in the tissue, type of the tumor, and the resolution of imaging equipment. These uncertainties can reduce the extent of ablation in the tissue, thereby affecting the effectiveness of the treatment.PurposeThe aim of this work is to understand the effect of these treatment uncertainties on the treatment outcome for irreversible electroporation (IRE) in the case of colorectal liver metastasis (CRLM). Understanding the nature and extent of these effects can help us identify the influential treatment parameters and build better models for predicting the treatment outcome.MethodsThis is an in silico study using a static computational model with a custom applicator design, spherical tissue, and tumor geometry. A nonlinear electrical conductivity, dependent on the local electric field, is considered. Morris analysis is used to identify the influential treatment parameters on the treatment outcome. Seven treatment parameters pertaining to the relative tumor location with respect to the applicator, the tumor growth pattern, and the electrical conductivity of tissue are analyzed. The treatment outcome is measured in terms of the relative tumor ablation with respect to the target ablation volume and total ablation volume.ResultsThe Morris analysis was performed with 800 model evaluations, sampled from the seven dimensional input parameter space. Electrical properties of the tissue, especially the electrical conductivity of the tumor before ablation, were found to be the most influential parameter for relative tumor ablation and total ablation volume. This parameter was found to be about 4–15 times more influential than the least influential parameter, depending on the tumor size. The tumor border configuration was identified as the least important parameter for treatment effectiveness. The most desired treatment outcome is obtained by a combination of high healthy liver conductivity and low tumor conductivity. This information can be used to tackle worst‐case scenarios in treatment planning. Finally, when the safety margins used in the clinical applications are accounted for, the effects of uncertainties in the treatment parameters reduce drastically.ConclusionsThe results of this work can be used to create an efficient surrogate estimator for uncertainty quantification in the treatment outcome, that can be utilized in optimal real‐time treatment planning solutions.
Recent developments on Junin virus, a causative agent for Argentine haemorrhagic fever
Authors: Kumar Sumit , Yadav Dharna , Singh Divya , Shakya Kriti , Rathi Brijesh , Poonam  
Published: January 2023

AbstractJunin virus consists of ribonucleic acid as the genome and is responsible for a rapidly changing tendency of the virus. The virus is accountable for ailments in the human body and causes Argentine Haemorrhagic Fever (AHF). The infection is may be transmitted through contact between an infected animal/host and a person, and later between person to person. Prevention of outbreaks of AHF in humans can be a tough practice, as their occurrence is infrequent and unpredictable. In this review, recent information from the past 5 years available on the Junin virus including the risk of its emergence, infectious agents, its pathogenesis in humans, available diagnostic and therapeutic approaches, and disease management has been summarised. Altogether, this article would be highly significant in understanding the mechanistic basis behind virus interaction and other processes during the life cycle. Currently, no specific therapeutic options are available to treat the Junin virus infection. The information covered in this review could be important for finding possible treatment options for Junin virus infections.
A Label‐Free and Continuous Fluorescence Detection for L–DOPA Decarboxylase Activity Based on Supramolecular Tandem Assay
Authors: Ren Siying , Geng Wen‐Chao , Cui Xuexian , Wu Bian , Zheng Zhe 
Published: January 2023

AbstractL–DOPA decarboxylase (DDC) deficiency causes serious progressive neurodegenerative disorders. Developing a sensitive enzyme activity monitoring and inhibitors or activators screening approach is highly on demand for DDC deficiency diagnosis. Here, we report a simple and sensitive fluorescence supramolecular tandem assay based on reporter pair of cucurbit[7]uril and acridine orange for DDC activity monitoring continuously. Furthermore, this strategy demonstrates the potential of STA to screen inhibitors of DDC.
Disrespectful colleagues, dysfunctional parenting: The effect of workplace incivility on parental attitudes, well‐being and behaviours
Authors: Dionisi Angela M. , Dupré Kathryne E. 
Published: January 2023

AbstractTwo dyadic studies address the link between workplace incivility and dysfunctional (i.e., authoritarian and permissive) parenting, and the role played by parent cognitions and well‐being in these relationships. One hundred and forty‐eight working mother‐spouse dyads participated in Study 1. Mothers reported on their own workplace incivility experiences and parenting self‐efficacy, while husbands rated mothers' authoritarian parenting behaviour. Results showed that parenting self‐efficacy mediates the effects of workplace incivility on authoritarian parenting. Study 2 sought to replicate and extend these findings with a sample of one hundred and seventy‐five working parent‐spouse dyads. Working mothers and fathers reported on their own workplace incivility experiences, parenting self‐efficacy and burnout, while their spouses rated their authoritarian and permissive parenting. The moderating effects of romantic relationship conflict were also assessed. Results supported the role of self‐efficacy in mediating the relationship between workplace incivility and authoritarian parenting, with effects exacerbated among those experiencing higher levels of romantic relationship conflict. Moreover, incivility related to working parents' burnout, and in turn, permissive parenting. Our findings shed light on an understudied social context wherein workplace incivility may shape one's personal life, and broadens our understanding of the nature, scope, and impact of this workplace problem.
Bioactive Nanogels Mimicking the Antithrombogenic Nitric Oxide‐Release Function of the Endothelium
Authors: Hosseinnejad Aisa , Ludwig Nadine , Mersmann Sina , Winnerbach Patrick , Bleilevens Christian , Rossaint Rolf , Rossaint Jan , Singh Smriti 
Published: January 2023

AbstractNitric oxide (NO) plays a significant role in controlling the physiology and pathophysiology of the body, including the endothelial antiplatelet function and therefore, antithrombogenic property of the blood vessels. This property of NO can be exploited to prevent thrombus formation on artificial surfaces like extracorporeal membrane oxygenators, which when come into contact with blood lead to protein adsorption and thereby platelet activation causing thrombus formation. However, NO is extremely reactive and has a very short biological half‐life in blood, so only endogenous generation of NO from the blood contacting material can result into a stable and kinetically controllable local delivery of NO. In this regards, highly hydrophilic bioactive nanogels are presented which can endogenously generate NO in blood plasma from endogenous NO‐donors thereby maintaining a physiological NO flux. It is shown that NO releasing nanogels could initiate cGMP‐dependent protein kinase signaling followed by phosphorylation of vasodilator‐stimulated phosphoprotein in platelets. This prevents platelet activation and aggregation even in presence of highly potent platelet activators like thrombin, adenosine 5′‐diphosphate, and U46619 (thromboxane A2 mimetic).
Carbon‐Nitride Popcorn—A Novel Catalyst Prepared by Self‐Propagating Combustion of Nitrogen‐Rich Triazenes
Authors: Ma Jinchao , Das Jagadish , Zhang Jiaheng , Cheng Jian , Sorcar Saurav , Rosen Brian A. , Shekhter Pini , Dobrovetsky Roman , Flaxer Eli , Yavor Yinon , Shen Ruiqi , Kaminker Ilia , Goldbourt Amir , Gozin Michael 
Published: January 2023

AbstractThe interest in development of non‐graphitic polymeric carbon nitrides (PCNs), with various C‐to‐N ratios, having tunable electronic, optical, and chemical properties is rapidly increasing. Here the first self‐propagating combustion synthesis methodology for the facile preparation of novel porous PCN materials (PCN3‐PCN7) using new nitrogen‐rich triazene‐based precursors is reported. This methodology is found to be highly precursor dependent, where variations in the terminal functional groups in the newly designed precursors (compounds 3–7) lead to different combustion behaviors, and morphologies of the resulted PCNs. The foam‐type highly porous PCN5, generated from self‐propagating combustion of 5 is comprehensively characterized and shows a C‐to‐N ratio of 0.67 (C3N4.45). Thermal analyses of PCN5 formulations with ammonium perchlorate (AP) reveal that PCN5 has an excellent catalytic activity in the thermal decomposition of AP. This catalytic activity of PCN5 is further evaluated in a closer‐to‐application scenario, showing an increase of 18% in the burn rate of AP‐Al‐HTPB (with 2 wt% of PCN5) solid composite propellant. The newly developed template‐ and additive‐free self‐propagating combustion synthetic methodology using specially designed nitrogen‐rich precursors should provide a novel platform for the preparation of non‐graphitic PCNs with a variety of building block chemistries, morphologies, and properties suitable for a broad range of technologies.