bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive modeling of ischemic stroke, identification of relevant subgroups, and drug prediction based on multiple programmed cell death patterns
Authors: Yang Huifeng , Shen Jing , Lu Minyan , Feng Yu 
Published: April 2023

Abstract
Background: Ischemic stroke is the second leading cause of mortality and disability globally. Along with many immune and disease conditions, Programmed cell death (PCD) also has a critical role in ischemic stroke and may serve as a diagnostic indicator of ischemic stroke.
Methods: From the Gene Expression Omnibus database (GEO), two ischemic stroke datasets were chosen, one for training and the other for the validation group. From the KEGG and other databases, 12 patterns of PCD-related genes were selected. Differentially expressed genes (DEG) were found using Limma analysis; functional enrichment analysis;machine learning least absolute shrinkage and selection operator (LASSO) regression; candidate immune-related central genes were identified using Random Forest along with the construction of a protein-protein interaction network (PPI) and an artificial neural network (ANN) for validation. In order to diagnose an ischemic stroke, the Receiver operating characteristic (ROC) curve was plotted, the diagnostic model was validated by qRT-PCR, immune cell infiltration was investigated to observe immune cell dysregulation in ischemic stroke, and the expression of candidate models under different isoforms was analyzed by consensus clustering (CC). Finally, drugs associated with candidate genes were collected through the Networkanalyst online platform.
Results: A total of 71 genes were shown to be the crossover of DEG and PCD-related genes in ischemic stroke, and six candidate genes were finally identified by machine learning to establish a diagnostic prediction model. After using an artificial neural network (ANN) for validation, ROC curve plotting, and qRT-PCR validation for diagnostic value assessment. The outcomes demonstrated that the prediction model had a high diagnostic value. In the immune infiltration analysis, significant variability of NKT was found in ischemic stroke patients. Seven drugs associated with candidate genes were collected from the Networkanalyst online platform.
Conclusion: A diagnostic prediction model with a good effect in the training group and validation group (AUC 0.94, CI 1.00-0.88 and AUC 0.91, CI 0.97-0.86, respectively), along with a good phenotype in qRT-PCR validation by comprehensive analysis was obtained. Additionally, the drugs (C646 substance, Cyclosporine, Decitabine, Dexamethasone, Resveratrol, Silicon Dioxide, and Tretinoin) that might be useful in the treatment of ischemic stroke were obtained.
Effects of triticale flour on the quality of honey cookies
Authors: Kandrokov Roman 
Published: April 2023

Flour confectionery products are highly popular in Russia, especially honey cookies (pryanik). In order to increase their nutritional value, wheat flour can be replaced by triticale flour rich in essential amino acids and minerals. This study aimed to determine the effects of triticale flour on the quality of honey cookies.
The control cookie sample was made from premium wheat flour, while the test samples were made from mixtures of wheat and triticale flours in various ratios (10–90%), as well as from 100% triticale flour of grade T-80. Standard methods were applied to determine the cookies’ sensory and physicochemical characteristics, as well as their nutritional value and contents of minerals, vitamins, and amino acids.
All the samples with triticale flour showed good sensory characteristics. Adding up to 30% of triticale flour did not change the taste and aroma of honey cookies, whereas larger amounts of triticale flour made them sweeter and more aromatic. The test samples from 100% of triticale flour had higher contents of essential amino acids (arginine, valine, histidine, isoleucine, leucine, lysine, methionine, and threonine) than the control sample from premium wheat flour. The contents of micro- and macroelements also increased with larger amounts of triticale flour in the formulation. While adding triticale flour increased the protein content in the test honey cookies, it had no significant effect on their fat and carbohydrate contents, or the calorie content. The tests showed that 60:40% was the optimal ratio of wheat and triticale flours.
Replacing wheat flour with 40% of triticale flour provided the finished product with good sensory properties and high contents of proteins, vitamins, essential amino acids, as well as micro- and macroelements. Thus, triticale flour proved to be a good replacement for wheat flour in the production of honey cookies.
CAR Selectively Enhances the Pulmonary Vasodilatory Effect of Fasudil in a Microsphere Model of Pulmonary Hypertension
Authors: Rothman Abraham , Restrepo Humberto , Evans William N. , Sarukhanov Valeri , Mann David 
Published: April 2023

Background:
Despite the approval of several medications for pulmonary hypertension, morbidity and mortality are unacceptably high. Systemic hypotension may limit the use of pulmonary hypertension medications.

Objectives:
This study aimed to assess whether the homing peptide CAR (CARSKNKDC) improves the vasodilatory selectivity of fasudil in the pulmonary circulation or systemic circulation in a porcine pulmonary hypertension model.

Materials and Methods:
Pulmonary hypertension (to approximately 2/3-3/4 systemic pressure levels) was induced by chronic and acute administration of microspheres in 3 micro Yucatan pigs (mean weight 19.9 kg, mean age 4.3 months). Fasudil (0.3 mg/kg) was administered without and with CAR (1.5 mg/kg), and the effect on aortic (Ao) and right ventricular (RV) pressure was recorded with indwelling catheters.

Results:
Immediately after fasudil administration, there was a decrease in Ao pressure followed by prompt recovery to baseline. The RV pressure decrease was progressive and sustained. Fasudil alone resulted in a 12% decrease in RV pressure, whereas co-administration of CAR with fasudil resulted in a 22% decrease in RV pressure (p < 0.0001). Fasudil alone caused an average decrease of 34% in the RV/Ao pressure ratio, and fasudil + CAR caused an average decrease of 40% in the RV/Ao pressure ratio (p < 0.0001).

Conclusion:
The homing peptide CAR selectively enhanced the acute vasodilatory effects of fasudil on the pulmonary vascular bed in a porcine experimental model of pulmonary hypertension.
Educação e o sistema prisional: Percepção das mulheres privadas de liberdade
Authors: Tiellet Maria do Horto Salles , Araújo da Silva Ana Luiza de 
Published: April 2023

O objetivo deste artigo é dar destaque à percepção das mulheres da Unidade Prisional Feminina de Cáceres-MT/BR sobre a educação, e a questão a ser respondida é: qual a percepção que as mulheres privadas de liberdade na cadeia feminina de Cáceres têm sobre a educação, especialmente a prisional? O estudo é descritivo, do tipo Estudo de Caso e de abordagem qualitativa. O local da investigação foi a Unidade Prisional de Cáceres-MT/BR. As informações foram coletadas em entrevista com cinco mulheres selecionadas através dos seguintes critérios: condenadas; residentes em Cáceres; mães com filhos em idade escolar e envolvidas nas atividades escolares na Unidade Prisional. Utilizou-se a técnica de Análise de Conteúdo de Laurence Bardin (1977), aplicada à sistematização dos dados da entrevista, organizados segundo os eixos temáticos: Delito, Sistema Prisional, Família dos quais foram extraídos fragmentos relacionados à unidade de registro: educação. Um dos resultados do estudo mostra que as mulheres privadas de liberdade manifestam esperança e interesse pela educação (escolarização e/ou cursos profissionalizantes), não somente voltada à remição, mas como instrumento para a melhoria das suas condições de vida ao retornarem à sociedade.
Analisis terhadap Kinerja Instalasi Pengolahan Air Limbah (IPAL) pada Industri Gudeg Kaleng di PT XYZ, Yogyakarta
Authors: Apriliyani Ima , Ainuri Makhmudun , Suyantohadi Atris 
Published: April 2023

Industri Pengalengan Guded di PT. RD, Yogyakarta memproduksi Produk Gudeg Kaleng untuk dipasarkan baik didalam negeri dan keluar negeri. Pada unit Pengolahan air limbah (IPAL) PT RD setelah dilakukan pengujian nilai pH, BOD5, COD, TSS, dan suhu efluen IPAL menunjukkan ketidak sesuaian nilai berdasarkan Peraturan Daerah Istimewa Yogyakarta Nomor 7 Tahun 2016. Penelitian ini bertujuan untuk melakukan analisis kinerja pada unit IPAL PT RD terhadap parameter pH, BOD, dan COD dan usulan perbaikan terhadap Kinerja IPALnya agar dapat beroperasi menghasilkan efluen yang sesuai dengan baku mutu yang dipersyaratkan pemerintah. Metoda penelitian dalam analisa kinerja IPAL dilakukan menggunakan Analisis Dimensi berdasarkan data-data perhitungan secara kuantitatif dan deskriptif. Dari analisa kinerja IPAL didapatkan factor penyebab ketidaksesuainya kinerja IPAL disebabkan 1) ukuran saringan yang kurang sesuai yaitu 39 cm×100 cm, 2) kondisi scum yang kotor tidak dibersihkan. 3) bak pengolahan anaerob yang digunakan hanya dapat mengolah beban COD 6,32 kg COD/m3.hari dan beban BOD5 1,51 kg BOD5/m3.hari sedangkan beban COD yang harus diolah melebihi kapasitas yang besarnya 6,74 kg COD/m3.hari dan beban BOD 1,71 kg BOD5/m3.hari, 4) penggunaan bakteri yang tidak sesuai dengan jenis pengolahan dan 5) tidak adanya proses netralisasi. Usulan perbaikan berdasarkan analisa kinerja IPAL yang diteliti; 1) penggantian saringan dengan ukuran yang sesuai yaitu 39 cm×110 cm; 2) pembersihan scum dan penambahan koagulan; 3) penggunaan teknologi biofilter anaerob dengan waktu tinggal 32,71 jam, organic loading rate 7,85 kg COD/m3.hari, hydraulic loading rate 0,0036 m3/m2.jam, pemasangan bioball dari material PVC, berbentuk bola, diameter 3 cm, luas kontak spesifik 200-240 m2/m3, porositas rongga 0,92, berwarna hitam dan volume 0,94 m3, pemasangan pipa dengan panjang 50-60 cm; 4) penggunaan Bakteri Nutrabact Anaerob dengan dosis pemakaian pertama 90-230 ml dan pemakaian harian 47 ml yang dibagi rata ke tujuh kolom biofilter; 5) netralisasi dengan membuka kedua bak kontrol dan penambahan kapur, serta pengontrolan efluen.
EVALUATION OF VATERIA INDICA MODIFIED GUM AS A RELEASE RETARDANT MATRIX IN THE TABLET DOSAGE FORM
Authors: FEGADE TUSHAR D. , PATIL VIJAY R. , DESHMUKH TUSHAR A. 
Published: April 2023

Objective: A natural gum from Vateria indica was investigated as a novel matrix-forming material for sustained drug delivery using diclofenac potassium as a model drug. Methods: In the current investigation, we formulated a matrix tablet using chloroform soluble gum portion of Vateria indica modified gum (VIMG) as a natural matrix-forming agent. It was used with a drug-polymer ratio ranging from 1:0.5 to 1:4.5. The pre-compression study of the powder blends was done by calculating bulk density, tapped density, angle of repose, and carr’s index, compressibility, and hausner’s ratio. The tablets were prepared by direct compression method and prepared tablets were evaluated and were found according to the official guidelines by pharmacopeia. The in vitro drug release was carried out using USP paddle type II apparatus and the release was found to be sustained. Results: The formulation VIMG-5 containing drug: polymer ratio 1:2.5 showed the 96.26%±1.73 drug release in 12 h. The results showed that chloroform soluble fraction of Vateria indica can be used as a drug release modifier to delay the rate of drug release, which depended on the amount of gum composition, as the concentration of gum was increased, there was sustained the drug release with promising accelerated stability. Conclusion: The evaluation studies on sustained release matrix tablets using Vateria indica chloroform soluble portion of gum as natural material demonstrate the multivariate applications such as matrix forming, binder, and release retardant of the gum in tablet formulation.
HUBUNGAN KESEHATAN TANAMAN TERHADAP PENYERBUKAN KELAPA SAWIT
Authors: Susanto Agus , Prasetyo Agus Eko , Priwiratama Hari 
Published: April 2023

Tandan buah kelapa sawit yang dipanen dapat menggambarkan proses penyerbukan yang terjadi pada 6 bulan sebelumnya dan keadaan nutrisi selama proses perkembangan buah. Penyerbukan sangat dipengaruhi oleh ketersediaan polen dengan viabilitas yang tinggi dan kecukupan populasi serangga penyerbuk Elaeidobius kamerunicus. Penelitian ini mengkaji dua kelompok tanaman dengan kondisi fisik yang berbeda, tanaman jagur dan tanaman kurus. Kajian dilakukan masing-masing pada tanaman tahun tanam 2000, 2006, 2010. Pengamatan meliputi penghitungan nilai fruit set dan fruit to bunch tandan kelapa sawit, produksi dan viabilitas polen dari bunga jantan yang dihasilkan, jumlah populasi kumbang E. kamerunicus per ha, dan analisis hara daun dan tanah. Hasil kajian menunjukkan bahwa nilai fruit set dan fruit to bunch pada tanaman kurus jauh lebih rendah dibandingkan dengan tanaman jagur. Secara umum, semakin tua umur tanaman maka fruit set dan fruit to bunch semakin tinggi. Nilai fruit set sangat dipengaruhi oleh produksi dan viabilitas polen dari bunga jantan mekar dan kecukupan populasi E. kamerunicus yang selalu di atas 20.000 kumbang/ha. Sementara itu, nilai fruit to bunch sangat dipengaruhi oleh ketersediaan nutrisi dalam tanah dan konsentrasi hara dalam daun kelapa sawit.
Тогтвортой хөгжлийн боловсролын зорилгыг хэрэгжүүлэхэд их, дээд сургуулиудын гүйцэтгэх үүрэг
Authors: Б Бурмаа 
Published: April 2023

Тогтвортой хөжлийн зорилгыг хэрэгжүүлэхэд их, дээд сургуулиудын гүйцэтгэх, үүрэг хариуцлагын талаар НҮБ. ЮНЕСКО-ийн албан ёсны бичиг баримтуудад тусгагдаж буй үзэл санаанууд, түүнийг хэрэгжүүлэх үйл явцын талаар хийж буй харьцуулсан судалгааны үр дүнгээс тодорхой асуудлаар товч тойм бэлтгэн агуулгыг дараах бүтэцтэйгээр боловсрууллаа. Үүнд:
• Тогтвортой хөгжлийн түүхэн замналаас.
• Дээд боловсролын салбар дахь тогтвортой хөгжлийн боловсролын үйл явцаас (2000-2015).
• Тогтвортой хогжил ба тогтвортой хогжлийн боловсролын зорилго (2015-2030).
Удаан M^{-}+He мөргөлдөөний үед электроны корреляц тооцох асуудал
Authors: Х Цоохүү , Н Цогбадрах 
Published: April 2023

An adiabatic electronic wave function for helium atoms depending on distance between the heavy particles (the negative meson and the target nuclear) is constructed. Both the radial and angle correlations are included in the wave function and the adiabatic electronic term for the He(1s2)+M- system is calculated. It is shown that the adiabatic electronic term for the elastic (M-+He(1s2) ) and ionization (M-+He(1s)) channels cross twice at the distance R1=0.88a0 and R2=0.215a0 between heavy particles. A possible corrections to the theory for ionization of atoms by slow meson impact, due to the second crossing point (R2), are discussed.
Их энергитэй цөм-цөмийн мөргөлдөөний үед үүсэх фрагментүүдийн гаж харилцан үйлчлэлийн судалгаа
Authors: Б Отгоолой , Ш Гэрбиш 
Published: April 2023

Представлены результаты экспериментов по исслледованию фрагментов во взаймодействиях дейтрона с блоками мишеней из меди. Разработан активационный метод воставления кривой поглощения вторичных частиц и фрагментов в мишень, генерируюмых в этих взаймодействиях. Определено сечение неупругого взаймодействия дейтрона с ядром меди при энергий 7.3ГэВ.
Обнаружены аномальные измения в выходах изотопов Со-58, Со-60 и Mn-54, образающихся при облучений сборки мишеней из меди (диаметр 80 мм, толщина 1 мм) в пучке дейтрона с энергией 7.3 ГэВ. Оценна средняя длина пробега аномальных фрагментов (1,77±0.79 мм)
Knowledge on the Validity of the Hadith on Veil, the Obligation to Wear and Its Application in Social Life: A Case Study at UIN Alauddin Makassar
Authors: Hafid Erwin , Mahmuddin Mahmuddin , Mustafa Kamal St Ibrah , M. Jakfar Tarmizi , Syahabuddin Syahabuddin 
Published: April 2023

This study seeks to assess the impact of students' degree of comprehension on the veracity of the hadith on veil, the law governing its wearing, and its application in their social lives. This study is a mixed-methods approach, using a case study as the methodology to get a full grasp of a specific legal matter in order to generate more understanding on the issue of veil. The data were collected through interviews, literature studies and surveys. The results revealed that the respondents' knowledge on the authenticity of the hadith was modest, while their comprehension of the legislation governing the wearing of the veil ranged between a lack of understanding and a sufficient understanding, and their application in daily life was quite high. In addition, it was discovered that there were reasons that influenced their persistent usage of the veil, given their strong commitment to doing so. These considerations include the external supports, for example the support of friends, families, and communities. Supposedly, if the acceptance of new behavior is founded on information, awareness, and a good attitude, this kind of behavior will be persistent. If, on the other hand, a behavior is not founded on knowledge and awareness, it will be easily left out. This case study also found that there were factors other than knowledge that influenced female students in social applications to wear the veil, namely support from family, friends and organizations.In the future efforts are needed so that knowledge about the authenticity and content of hadith law regarding the veil can be increased. So that a person can strike a balance between the spirit of religion and his knowledge of the law governing the text's authenticity (hadith) and Islamic law.
The Legal Vacuum on Access to Higher Education for Refugees in Indonesia: Islamic Claim for Aceh Responsibility
Authors: Aiyub Kadir M. Yakub , Rivaldi Aditya , Farsia Lena , Bantasyam Saifuddin 
Published: April 2023

This article investigates the prospect of granting refugee students the opportunity to enroll in higher education in Indonesia, particularly Aceh. Due to the vacuum of law on the rights for higher education for refugees. This article explores the possibility of religious claim on the rights for higher education for refugees. This study aims to prove that amidst the vacuum of law on the higher education rights for the refugee, Indonesia is still legally, socially, and religiously responsible in providing higher education access for refugees. Using doctrinal and quantitative legal research. This research demonstrated that Indonesia should be able to provide higher education for refugees by minimally but significantly changing the meaning of several of its higher education regulations. The responsibility bear by Indonesia is stipulated clearly in its constitutional preamble, as well as article 28(C)1 of Indonesia constitution. This report also confirmed that Aceh, with its past and present position, meets the requirement of an “Islamic Land,” and hence has a fundamental religious commitment to give refugees with the same rights as its inhabitants. This report also suggests technical collaboration or assimilation with the Global Education Convention system, as well as combining the Paket C and the UNESCO Qualifications Passport for Refugee systems to address any refugee's paperwork and qualification issues. This study contributes to the advocacy and support for significant humanitarian aid that Indonesia, particularly Aceh, may provide to refugees in order to help them prepare for a better future.
Songkabala Tradition in the Makassarese Society: Local Values and Messages of the Al-Qur’an an Anthropological Perspective on Islamic Law
Authors: Sohrah Sohrah , Husna Asmaul , Akbar Rahmatul , Sugirman Andi , Arfah M. Thahir 
Published: April 2023

Local traditions as religious practices in Indonesian society experience dialectic and integration of Islamic teachings. Every ethnicity in Indonesia has socio-cultural mechanisms in dealing with calamities and disasters which are influenced by religion and customs. This then dialectic with the practice of Islamic law. The study seeks to examine songkabala, a tradition of mutual acceptance in the Makassarese society. These traditions are local values that contain Al-Qur’anic teachings. This is an empirical legal study employing an anthropological perspective on Islamic law. In-depth interviews and literature reviews focused on three districts inhabited by Makassarese, namely Maros, Gowa, and Takalar, were employed to collect data. The study indicates that songkabala is the spirit of Al-Qur’anic verses associated to human responses to calamity, including remembrance of Allah, gratitude, and ritualized prayer. Songkabala is a Makassarese folk tradition that contains Al-Qur’anic themes. The verses of the Al-Qur’an indicate that the command to pray and the remembrance of Allah are incorporated into the songkabala ritual. Consequently, there is no incompatibility between the songkabala tradition and the teachings of the Al-Qur’an.
Transformation of Maqāṣid Shari‘āh in Divorce Mediation in Religious Courts: Revitalization of the Bugis-Mandar Customs, Indonesia
Authors: Fikri Fikri , Bedong Muhammad Ali Rusdi , Salim Muhyiddin , Muthalib Salman Abdul , Abubakar Ali 
Published: April 2023

The focus of this research discusses the transformation of maqāṣid shari'āh in mediation practices in divorce cases, and the revitalization of adat in mediation practices in Bugis and Mandar communities. This study is a field legal research using historical and socio-anthropological approaches, while the data is analyzed using maqāṣid shari'ah theory and social change theory. Data collection techniques are based on literature studies on legal sources related to the discussion.This study concludes that divorce is an extraordinary case in the religious courts, dynamics of mediation practice in Religious Courts have successful mediation for a written peace agreement in peace deed, other mediation products are partially successful mediation and partially unsuccessful mediation, mediation products are not successful is that husband and wife are committed to divorce; maqāṣid shari‘āh transformation can be a major consideration by judges in mediation practice to save households on the verge of collapse, so that maqāṣid shari‘āh is very urgent to place in Perma No.1 of 2016, and revitalization of Bugis-Mandar customary is an effort to revive the value of life sirondo-rondoi, siamasei, sianuang pa'mai, and sibaliparri, also animate shara’ which is performed petta kalie (Bugis) or puang kali’ (Mandar).