bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disconnect between the effects of serelaxin on renal function and outcome in acute heart failure
Authors: Beldhuis I. E. , ter Maaten J. M. , Figarska S. M. , Damman K. , Pang P. S. , Greenberg B. , Davison B. A. , Cotter G. , Severin T. , Gimpelewicz C. , Felker G. M. , Filippatos G. , Teerlink J. R. , Metra M. , Voors A. A. 
Published: January 2023

Abstract
Background
We aimed to study whether improvement in renal function by serelaxin in patients who were hospitalized for acute heart failure (HF) might explain any potential effect on clinical outcomes.

Methods
We included 6318 patients from the RELAXin in AHF-2 (RELAX-AHF2) study. Improvement in renal function was defined as a decrease in serum creatinine of ≥ 0.3 mg/dL and ≥ 25%, or increase in estimated glomerular filtration rate of ≥ 25% between baseline and day 2. Worsening renal function (WRF) was defined as the reverse. We performed causal mediation analyses regarding 180-day all-cause mortality (ACM), cardiovascular death (CVD), and hospitalization for HF/renal failure.

Results
Improvement in renal function was more frequently observed with serelaxin when compared with placebo [OR 1.88 (95% CI 1.64–2.15, p < 0.0001)], but was not associated with subsequent clinical outcomes. WRF occurred less frequent with serelaxin [OR 0.70 (95% CI 0.60–0.83, p < 0.0001)] and was associated with increased risk of ACM, worsening HF and the composite of CVD and HF or renal failure hospitalization. Improvement in renal function did not mediate the treatment effect of serelaxin [CVD HR 1.01 (0.99–1.04), ACM HR 1.01 (0.99–1.03), HF/renal failure hospitalization HR 0.99 (0.97–1.00)].

Conclusions
Despite the significant improvement in renal function by serelaxin in patients with acute HF, the potential beneficial treatment effect was not mediated by improvement in renal function. These data suggest that improvement in renal function might not be a suitable surrogate marker for potential treatment efficacy in future studies with novel relaxin agents in acute HF.

Graphical abstract
Central illustration. Conceptual model explaining mediation analysis; treatment efficacy of heart failure therapies mediated by renal function.
Dynamical systems model of development of the action differentiation in early infancy: a requisite of physical agency
Authors: Fujihira Ryo , Taga Gentaro 
Published: January 2023

AbstractYoung infants are sensitive to whether their body movements cause subsequent events or not during the interaction with the environment. This ability has been revealed by empirical studies on the reinforcement of limb movements when a string is attached between an infant limb and a mobile toy suspended overhead. A previous study reproduced the experimental observation by modeling both the infant’s limb and a mobile toy as a system of coupled oscillators. The authors then argued that emergence of agency could be explained by a phase transition in the dynamical system: from a weakly coupled state to a state where the both movements of the limb and the toy are highly coordinated. However, what remains unexplained is the following experimental observation: When the limb is connected to the mobile toy by a string, the infant increases the average velocity of the arm’s movement. On the other hand, when the toy is controlled externally, the average arm’s velocity is greatly reduced. Since young infants produce exuberant spontaneous movements even with no external stimuli, the inhibition of motor action to suppress the formation of spurious action-perception coupling should be also a crucial sign for the emergence of agency. Thus, we present a dynamical system model for the development of action differentiation, to move or not to move, in the mobile task. In addition to the pair of limb and mobile oscillators for providing positive feedback for reinforcement in the previous model, bifurcation dynamics are incorporated to enhance or inhibit self-movements in response to detecting contingencies between the limb and mobile movements. The results from computer simulations reproduce experimental observations on the developmental emergence of action differentiation between 2 and 3 months of age in the form of a bifurcation diagram. We infer that the emergence of physical agency entails young infants’ ability not only to enhance a specific action-perception coupling, but also to decouple it and create a new mode of action-perception coupling based on the internal state dynamics with contingency detection between self-generated actions and environmental events.
Validation of the International Consultation on Incontinence Questionnaire-Pediatric Lower Urinary Tract Symptoms (ICIQ-CLUTS) for Spanish-speaking children
Authors: Blanco-Diaz Maria , Rodriguez-Rodriguez Alvaro Manuel , Casaña Jose , Hernandez-Sanchez Sergio 
Published: January 2023

AbstractThe International Consultation on Incontinence Questionnaire-Pediatric Lower Urinary Tract Symptoms (ICIQ-CLUTS) is a 12-item self-administered tool to screen lower urinary tract symptoms (LUTS) in children. The aim of this study is to translate and validate the ICIQ-CLUTS into Spanish (ICIQ-CLUTS-Sp) and to study its psychometric properties. The cross-cultural adaptation of the ICIQ-CLUTS was performed following international recommendations. The psychometric analysis of the ICIQ-CLUTS-Sp was carried out to determine the reliability, validity, and diagnostic accuracy in a sample of 155 children and parents who completed the Spanish version ICIQ-CLUTS. The reliability indicators for the ICIQ-CLUTS-Sp were excellent (Cronbach’s alpha was > 0.8 and ICC > 0.9 both for children’s and parents’ versions). There was a high Pearson r > 0.6 and a high agreement level between children’s and parents’ answers (ICC > 0.6), except in 4 items. For parents, the standard error of measurement (SEm) was 0.41, and the minimal detectable change (MDC) was 1.14 points. In children, these results were 0.42 and 1.16 points, respectively. Cut-off points greater than 15 points in the parent version or 16 points in the children version have the highest sensitivity and specificity for detecting LUTS. Conclusion: The Spanish version of the ICIQ-CLUTS questionnaire is a valid, reliable, and diagnostically accurate instrument to identify cases of children with LUTS. Therefore, it can be used to screen for lower urinary tract symptoms in Spanish speaking children and/or parents, as well as to monitor the effects of interventions.

What is Known:

• Lower urinary tract symptoms in children should be assessed multimodally using minimally invasive diagnostic procedures. One way to do this is to use the questionnaire to differentiate these cases in paediatric patients.

• A cross-cultural adaptation of the ICIQ-CLUTS questionnaire to Spanish has not yet been done.

What is New:

• Based on a comprehensive validation methodology, this study highlights that the ICIQ-CLUTSSp questionnaire has good psychometric properties.
Das gute Leben heute und morgen: Antibiotikaresistente Keime als Nachhaltigkeitsproblem in der Medizin
Authors: Bozzaro Claudia , Rupp Jan , Stolpe Michael , Schulenburg Hinrich 
Published: January 2023

ZusammenfassungIn einem ersten Kapitel wird am Beispiel der Entstehung von Antibiotikaresistenzen gezeigt, dass es in der Medizin spezifische Nachhaltigkeitsprobleme gibt, die letztlich zu einer Beeinträchtigung der Fähigkeit zukünftiger Patient:innen führen können, ihre Gesundheitsbedürfnisse zu befriedigen und ein gutes Leben zu leben. Nachdem in einem zweiten Kapitel auf den Nachhaltigkeitsbegriff genauer eingegangen wurde, wird im dritten Teil erläutert, dass und warum die Möglichkeit zur Befriedigung elementarer Gesundheitsbedürfnisse z. B. im Rahmen eines Capability-Ansatzes zu Recht als eine Bedingung für ein gutes Leben gilt. Das Konzept der Nachhaltigkeit der Vereinten Nationen fordert, die Ansprüche auf ein gutes Leben zukünftiger Patient:innen angemessen zu berücksichtigen. Im vierten Teil wird dargestellt, wie Nachhaltigkeitsforderungen im klinischen Kontext zu einem Nachhaltigkeits-Dilemma führen können, und geklärt, auf welche Weise mit diesem Dilemma umgegangen werden kann.
Non-Commutative Resolutions for the Discriminant of the Complex Reflection Group G(m, p, 2)
Authors: May Simon 
Published: January 2023

AbstractWe show that for the family of complex reflection groups G = G(m, p,2) appearing in the Shephard–Todd classification, the endomorphism ring of the reduced hyperplane arrangement A(G) is a non-commutative resolution for the coordinate ring of the discriminant Δ of G. This furthers the work of Buchweitz, Faber and Ingalls who showed that this result holds for any true reflection group. In particular, we construct a matrix factorization for Δ from A(G) and decompose it using data from the irreducible representations of G. For G(m, p,2) we give a full decomposition of this matrix factorization, including for each irreducible representation a corresponding maximal Cohen–Macaulay module. The decomposition concludes that the endomorphism ring of the reduced hyperplane arrangement A(G) will be a non-commutative resolution. For the groups G(m,1,2), the coordinate rings of their respective discriminants are all isomorphic to each other. We also calculate and compare the Lusztig algebra for these groups.
Among demons and killers: current and future potential distribution of two hyper successful invasive gammarids
Authors: Cancellario Tommaso , Laini Alex , Wood Paul J. , Guareschi Simone 
Published: January 2023

AbstractBiological invasions represent one of the main contemporary pressures facing freshwater ecosystems, and a better understanding of invasive species potential distributions is essential to prepare for future stressors. Crustacean invaders contribute significantly to global invasions with the Ponto-Caspian region being one of the primary donor areas for the Palearctic. The amphipods Dikerogammarus villosus and Dikerogammarus haemobaphes, popularly known as “killer” and “demon” shrimps, are emblematic of successful Ponto-Caspian invaders of European freshwaters. However, the geographical areas in which the abiotic environment is potentially suitable for them have not been investigated. To address this gap, current and future potential distributions were studied for the European Western Palearctic considering two scenarios and time periods (2050 and 2070) as well as the association between anthropogenic activities and individual species habitat suitability. Results show large areas of central-western Europe are currently suitable for both species and indicate some potential for range expansion within colder European areas. In particular, D. haemobaphes has the potential to expand its range further west and within southern parts of Europe. Scenarios of future climate change don’t provide evidence for further range expansion compared to the current conditions and suggest a reduction of range overlap within the most suitable areas. Results reveal lowland areas are at greatest risk of colonisation as well as a significant association with anthropogenic activities for both amphipods. The outcomes of the research could be used by resource managers for preparing and managing future changes of both species distributions and facilitate decision-making for monitoring and control.
Vaccine Targeting Alpha 1D-Adrenergic Receptor Improved Metabolic Syndrome in Mice
Authors: Li Xin , Ma Wenrui , Zhou Yanzhao , Li Chang , Shi Dingyang , Kuang Wenlong , Wu Jiacheng , Liao Yuhua , Qiu Zhihua , Zhou Zihua 
Published: January 2023

Abstract
Purpose
Metabolic syndrome (MetS) is a complex chronic disease that includes obesity and hypertension, with rising evidence demonstrating that sympathetic nervous system (SNS) activation plays a key role. Our team designed a therapeutic vaccine called ADRQβ-004 targeting the α1D-adrenergic receptor (α1D-AR). This study was performed to investigate whether the ADRQβ-004 vaccine improves MetS by modulating SNS activity.

Methods
C57BL/6N mice were fed a high-fat diet (HFD) and Nω-nitro-L-arginine methyl ester (L-NAME) combination diet for 18 weeks to elicit MetS. The MetS mice were subcutaneously immunized with the ADRQβ-004 vaccine four times to evaluate the therapeutic efficacy in obesity and hypertension and other associated ﻿abnormalities related to MetS by conducting echocardiographic, histological, and biochemical analyses.

Results
The ADRQβ-004 vaccine induced strong antibody production and maintained a high anti-ADR-004 antibody titer in MetS mice. The ADRQβ-004 vaccine improved obesity (P < 0.001) and decreased systolic blood pressure (P < 0.001). Improvements in dysregulated glucose homeostasis and dyslipidemia resulting from the ADRQβ-004 vaccine were also confirmed. Furthermore, the ADRQβ-004 vaccine attenuated cardiovascular functional (P = 0.015) and structural changes (P < 0.001), decreased fat accumulation (P = 0.012) and inflammation (P = 0.050) in the epididymal white adipose tissue, and alleviated hepatic steatosis (P = 0.043) involved in MetS. Moreover, the ADRQβ-004 vaccine improved systematic and visceral organs SNS activities in the MetS.

Conclusion
This study demonstrated for the first time that the ADRQβ-004 vaccine targeting α1D-AR improved obesity, hypertension, dyslipidemia, and dysglycemia, and further reduced end-organ damage, which may provide new motivation for MetS research.
Electrophysiological assessment of nutritional optic neuropathy: a case report
Authors: O’Neill Emily K. , Mankad Kshitij , Bowman Richard , Thompson Dorothy A. 
Published: January 2023

Abstract
Purpose
To report an unexpectedly asymmetric, progressive nutritional optic neuropathy associated with vitamin A deficient optic canal hyperostosis in a 15-year-old female with a long history of a restricted diet.

Methods
We performed comprehensive ophthalmic assessments in a fifteen-year-old female with a long history of restricted eating who presented with suspected nutritional optic neuropathy, predominantly affecting the right eye vision.

Results
A review of computerised tomography and magnetic resonance imaging revealed bilateral optic canal hyperostosis likely associated with vitamin A deficiency. Electrodiagnostic tests and optical coherence tomography provided structure–function evidence of bilateral retinal ganglion cell dysfunction and notably revealed severe loss of temporal fibres in the left eye which showed cecocentral scotoma but normal visual acuity. Although selective damage of the papillomacular bundle has been well-documented in nutritional and toxic optic neuropathies, compressive optic canal hyperostosis secondary to nutritional deficiency has been rarely reported.

Conclusions
Nutritional deficiencies are increasing in high-income countries and may be linked to the rise of gastrointestinal disorders, strict vegan and vegetarian diets and avoidant restrictive food intake disorder (ARFID) associated with conditions such as depression and autism spectrum syndrome (ASD). Our findings highlight the value of electrodiagnostic testing alongside imaging in complex nutritional optic neuropathies to help monitor, guide treatment and preserve remaining sight in a child.
Stakeholder perspectives on the use of VoiceThread as a multimodal alternative to conventional discussion board in distance education
Authors: Chen Julian , Bogachenko Tatiana 
Published: January 2023

AbstractThis pilot study explores and documents online students’ and their lecturer’s debut experiences of utilising VoiceThread (VT), a digital multimodal platform, as an alternative discussion space via Open Universities Australia (OUA). Feedback from the lecturer’s teaching log and interview was corroborated with his OUA students’ survey responses, and analysed in relation to student online learning experiences with VT and Discussion Board, as well as technological and affective aspects of both platforms. Findings indicate that VT has a stronger potential in boosting stakeholders’ online engagement and enjoyment of distance learning, thus fostering online community building. Specifically, VT creates not only a multimodal and dynamic platform in lieu of Discussion Board, but a supportive online learning environment that promotes more inclusive and ongoing interactions. Despite the positive results, VT was viewed by some students as technologically demanding, causing them to only read peer posts without responding. It is suggested that orientation training sessions and trial threads be made available to ease the students into VT. Aspects of tutorial group size and instructor support should also be considered for future online course delivery.
Comparison of voluntary and forced digital leaps in higher education – Teachers’ experiences of the added value of using digital tools in teaching and learning
Authors: Kallunki Veera , Katajavuori Nina , Kinnunen Päivi , Anttila Henrika , Tuononen Tarja , Haarala-Muhonen Anne , Pyörälä Eeva , Myyry Liisa 
Published: January 2023

AbstractThe study examines the benefits of digital tools in teaching and learning as experienced by university teachers in two different time periods: 1) during the controlled digital leap before the Covid-19 pandemic (2017–2019) and 2) during the emergency imposition of remote teaching in response to the lockdown aimed at containing the Covid-19 pandemic (2020). Teachers in different academic fields at a large multidisciplinary Finnish university (N1 = 303 and N2 = 265) responded to two open-ended questions as part of a broader questionnaire. The research identified four kinds of benefits related to digital teaching: (1) practical and administrative and (2) independence of time and place, implying practical and technical benefits; as well as (3) enhancing learning and (4) developing teaching, which are primarily pedagogical benefits, related to teaching and learning. Voluntary and forced digital leaps provided different kinds of consequences in teaching and learning. Digital tools generally provided practical and technological benefits for teaching and learning during the controlled digital leap, but they also had positive pedagogical effects. The forced digital leap, in turn, demonstrated the value of time-and-place-independent online teaching and learning. It also exposed differences among academic fields in how teachers experienced the benefits of using digital tools. Support of and training for university teachers should take into account the different needs of faculties and disciplines, and promote dialogue between pedagogical and technological interests.
Kinematic Modelling and Position Control of A 3-DOF Parallel Stabilizing Robot Manipulator
Authors: Latifinavid Masoud , Azizi Aydin 
Published: January 2023

AbstractThis paper focuses on investigating a parallel camera stabilizing manipulator with three angular degrees of freedom controlled by three linear actuators. An experimental setup is designed and manufactured to actively isolate the host vehicle's disturbing motions. The kinematic analysis of the manipulator combined with a controller is used to disturbance rejection coming from the base platform. Two inertia measurement units (IMU) are used for real-time feedback from the base and up-per platforms' orientation. A Kalman filter is implemented for handling the noises and drifts of the IMUs data. Inverse kinematics of the manipulator is used for calculating the actuating commands and velocity control of the linear motors. The experimental results of the proposed camera stabilizing system are shown. The results indicate its good capability in following the reference input of the controller. Considering the closed kinematic chain of the system and its stiff parallel architecture, this system can be a good choice for the stabilizing system of ground and aerial vehicles.
Association between School Contexts and the Development of Subjective Well-Being during Adolescence: A Context-Sensitive Longitudinal Study of Life Satisfaction and School Satisfaction
Authors: Wu Yi-Jhen , Becker Michael 
Published: January 2023

AbstractThe transition to secondary school may negatively impact adolescents’ psychosocial and subjective well-being development. However, how subjective well-being develops during secondary school and how school contextual factors, including aspects of ability grouping and achievement composition, are associated with the development of subjective well-being still require clarification. This study examined two measures of subjective well-being, life satisfaction and school satisfaction, to investigate the development of subjective well-being during secondary school. Moreover, school context variations in the form of school tracks and school-level achievement were analyzed to examine the extent to which ability grouping and achievement composition were associated with the development of subjective well-being. A large-scale longitudinal German dataset with four measurement points from grades 6 to 10 was analyzed (Time 1: N = 1,841; Mage = 12.20, SD = 0.81; 48.4% female; 45.3% immigrant students). The latent growth model revealed that life satisfaction and school satisfaction decreased statistically significantly during secondary school, yet school satisfaction showed a temporary increase between the end of primary school and right after the transition to secondary school. School tracks did not statistically significantly predict the magnitude of the decline in life satisfaction or school satisfaction. Only school-level achievement composition significantly negatively predicted the decline in life satisfaction, suggesting that students in schools with higher levels of achievement composition had a greater decrease in life satisfaction than their counterparts in schools with lower levels of achievement composition. Taken together, these findings contribute to the knowledge of how life and school satisfaction develop during secondary school and the long-term associations between subjective well-being and school context factors.
The Scott conjecture for large Coulomb systems: a review
Authors: Frank Rupert L. , Merz Konstantin , Siedentop Heinz 
Published: January 2023

AbstractWe review some older and more recent results concerning the energy and particle distribution in ground states of heavy Coulomb systems. The reviewed results are asymptotic in nature: they describe properties of many-particle systems in the limit of a large number of particles. Particular emphasis is put on models that take relativistic kinematics into account. While non-relativistic models are typically rather well understood, this is generally not the case for relativistic ones and leads to a variety of open questions.
The Spiral of Digital Falsehood in Deepfakes
Authors: Leone Massimo 
Published: January 2023

AbstractThe article defines the research field of a semiotically oriented philosophy of digital communication. It lays out its methodological perspective, pointing out how the fake has always been at the center of semiotic research. It traces the origin of deepfakes back to the conception of GANs, whose essential semiotic workings it expounds on. It enucleates the specificities of the digital fake, especially in the production of artificial faces. It reviews the deepfake phenomenon, enunciating its most recent statistics, prevalent areas of application, risks, and opportunities. It surveys the most current literature. It concludes by emphasizing the novelty of a situation in which the fake, in human societies and cultures, is produced mostly by machines. It stresses the desirability for a semiotic and interdisciplinary study of these productions.