bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitators and Barriers to Older Adult Participation in Cancer Trials: A Qualitative Study Exploring Patient-Caregiver Dyad Congruence
Authors: Mokhnatkin Janet V. , Bae Marie , Dale William , Tiwari Abhay , Patanapirom Jasmine , Sedrak Mina S. 
Published: April 2023

PURPOSE Family caregivers play an integral role in caring for older adults with cancer. Few studies have examined older adults with cancer and their family caregivers as a unit in a relationship or a dyad. Dyad congruence, or consistency in perspective, is relevant to numerous aspects of living with cancer, including the decision to enroll in a cancer clinical trial. METHODS Semistructured interviews of 32 older women (age ≥ 70 years) with breast cancer and their family caregivers (16 dyads) were conducted at both academic and community settings from December 2019 to March 2021 to explore perceived facilitators and barriers to cancer trials. Dyad congruence was defined as aligned (matching) perspectives, and incongruence was defined as misaligned (nonmatching) perspectives. RESULTS Five (31%) of 16 patients were age ≥80 years, 11 (69%) had nonmetastatic breast cancer, and 14 (88%) were treated in an academic setting. Six (38%) of 16 caregivers were in the 50-59 age group, 10 (63%) were female, and seven (44%) were daughters. Dyad congruence centered on the clinical benefit of trials and physician recommendation. However, compared with caregivers, patients were more motivated to contribute to science. Patients and caregivers also differed on the perceived extent to which the caregiver influenced enrollment. CONCLUSION Older patients with cancer and their caregivers generally agree about the facilitators and barriers to cancer trial enrollment, but some perceptions are misaligned. Further research is needed to understand whether misaligned perspectives between patients and caregivers influence clinical trial participation of older adults with cancer.
An arginase 2 promoter transgenic line illuminates immune cell polarisation in zebrafish
Authors: Hammond Ffion R. , Lewis Amy , Speirs Zoë C. , Anderson Holly E. , Sipka Tamara , Williams Lewis G. , Nguyen-Chi Mai , Meijer Annemarie H. , Wiegertjes Geert F. , Elks Philip M. 
Published: April 2023

ABSTRACT
Innate immune responses to inflammation and infection are complex and represent major challenges for developing much needed new treatments for chronic inflammatory diseases and drug-resistant infections. To be ultimately successful, the immune response must be balanced to allow pathogen clearance without excess tissue damage, processes controlled by pro- and anti-inflammatory signals. The roles of anti-inflammatory signalling in raising an appropriate immune response are underappreciated, representing overlooked potential drug targets. This is especially true in neutrophils, a difficult cell type to study ex vivo owing to a short lifespan, dogmatically seen as being highly pro-inflammatory. Here, we have generated and describe the first zebrafish transgenic line [TgBAC(arg2:eGFP)sh571] that labels expression of the anti-inflammatory gene arginase 2 (arg2) and show that a subpopulation of neutrophils upregulate arginase soon after immune challenge with injury and infection. At wound-healing stages, arg2:GFP is expressed in subsets of neutrophils and macrophages, potentially representing anti-inflammatory, polarised immune cell populations. Our findings identify nuanced responses to immune challenge in vivo, responses that represent new opportunities for therapeutic interventions during inflammation and infection.
Physiological and behavioral evidence for multiple spectral channels in the larval stomatopod visual system
Authors: McDonald Marisa S. , Cohen Jonathan H. , Porter Megan L. 
Published: April 2023

ABSTRACT
Larval stomatopods have generally been described as having a typical larval crustacean compound eye, which lacks the visual pigment diversity and morphological specializations of the well-studied stomatopod adult eye. However, recent work has suggested that larval stomatopod eyes are more complex than previously described. In this study, we provide physiological and behavioral evidence of at least three distinct photoreceptor classes in three species of larval stomatopods: Gonodactylellus n. sp., Gonodactylaceus falcatus and Pullosquilla n. sp. First, electroretinogram recordings were used to measure the spectral sensitivity of each species. Evidence for at least three spectral classes were identified in each: an ultraviolet, peaking at 340–376 nm; a short-wavelength blue, peaking at 455–464 nm; and a long-wavelength orange, peaking at 576–602 nm. Next, the behavioral response to light was investigated. We found that each species demonstrated positive phototactic responses to monochromatic stimuli across the UV–visible spectrum. In wavelength preference trials, distinct preferences among species were identified when different colored light stimuli were presented simultaneously. All species displayed a strong response to the UV stimulus, as well as responses to blue and orange stimuli, although at different response strengths, but no response to green. The results of this study demonstrate that larval stomatopods not only have multiple physiologically active spectral classes but they also display clear and distinct responses to wavelengths across the spectrum. We propose that the spectral classes demonstrated in each are related to visually guided ecological tasks of the larvae, which may differ between species.
Physical Activity Solutions to Decrease Occupational Stress
Authors: Aslakson Aaron , Melton Bridget , Bland Helen , Biber Duke 
Published: April 2023

Apply It!
After reading this article, fitness professionals will be able to:
• Understand the impact of occupational stress on employees.
• Understand how physical activity impacts occupational stress.
• Implement suggestions for on-site physical activity solutions and off-site physical activity promotion to impact occupational stress.
Historical Literacy and the Structuring Process of Historical Knowledge in Students
Authors: NIPPI AMALIA 
Published: April 2023

In the 19th century, history emerged as a professional cognitive faculty and historians tried to exempt historical writing from its rhetorical elements and literary features. According to Ricoeur, historical narration is defined as the logical organisation of heterogeneous elements, so that actors, actions, means and unpredictable events are transformed into a constitutionally organized whole with a plot, namely into a history (Kavvoura-Sissoura, 2011). History is not just the narration of war or definite events, but the attempt to restructure the past with the aim to interpret the past and maybe to predict the future. In the educational framework, historical knowledge does not include only the learning of events, as well as the development of skills that will make a person historically literate.
School history, with the contribution of the interpretive method, is a study of the historical past, the space and time, the intentionality and causality. It also records the historical context, so that students become historically literate. The main purpose of historical literacy is the distinction and understanding of historical knowledge, which is developed through historical description, narration and interpreting of text with the aim to obtain historical thinking, historical reasoning and historical consciousness.

Key words: history, historical literacy, historical knowledge
Suicide prevention program (SPP) in South Asian Countries: A protocol for systematic review
Authors: Borah Kallabi , Jose Tessy Treesa , Mysore Nagaraj Anil Kumar , Moxham Lorna 
Published: April 2023

Introduction: Every year, over 703,000 individuals lose their life by suicide and many individuals attempt suicide. Suicide occurs in all age groups and is the fourth major cause of death among 15–29-year-olds globally in 2019. A suicide prevention program (SPP) is a capacity-building program that helps gatekeepers to identify the risk of suicide. The objective of the review is to determine the effectiveness of SPP on the improvement of knowledge, attitude, and gatekeeper behaviour among gatekeepers in South Asian countries. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and PICO (Population, Intervention, Comparison, Outcome) format will be followed in this review. This review will include all interventional studies that provided a suicide prevention program to the gatekeepers as an intervention. The full-text articles will be included from the following databases, Scopus, PubMed (MEDLINE), Cochrane, PsycINFO, Web of Science, and CINAHL, published in peer-reviewed, indexed, and English language journals from the date of inception to 2022. A grey literature search and hand-search of reference lists of the included studies will also be done. A search strategy will be developed using keywords and MeSH terms for each database. Cochrane ROB-2 tool, JBI Critical Appraisal Checklist, Critical Appraisal Skills Program (CASP), and Mixed Methods Appraisal Tool (MMAT) will be used to evaluate the quality of individual studies. Analysis of the data will be done using narrative synthesis. Conclusions: This review will provide information on knowledge, attitude, and gatekeeper behaviour toward suicide prevention in college students and will be helpful for the prevention of suicide. Therefore, the authors plan to publish the review outcome through a peer-reviewed journal. Registration: The review is registered in PROSPERO (CRD42023387020).
Reliability of ankle dorsiflexor muscle strength, rate of force development, and tibialis anterior electromyography after stroke
Authors: Olsen Sharon , Taylor Denise , Niazi Imran Khan , Mawston Grant , Rashid Usman , Alder Gemma , Stavric Verna , Nedergaard Rasmus Bach , Signal Nada 
Published: April 2023

Background: Measures of hemiparetic ankle dorsiflexor muscle strength and rate of force development (RFD) are often used to determine the efficacy of rehabilitation interventions after stroke. However, evidence supporting the reliability of these measures is limited. This brief report provides a secondary analysis investigating the between-session reliability of isometric ankle dorsiflexor muscle strength, rate of force development (RFD), and tibialis anterior electromyography (TA EMG), in people with chronic stroke. Method: Participants (n=15) completed three maximal isometric contractions of the ankle dorsiflexor muscles as fast as possible using a rigid dynamometer. Tests were repeated seven days later. Outcomes included ankle dorsiflexor isometric maximal voluntary contraction (MVC), RFD in the first 200ms (RFD200ms), time to reach 90% MVC, and peak TA EMG. Data were analysed for 13 participants using intra-class correlation coefficients (ICC) and standard error of the measure (SEM). Results: When the mean of three trials was analysed, there was excellent reliability for isometric dorsiflexor MVC (ICC 0.97 [95% CI 0.92-0.99]), moderate reliability for TA EMG (ICC 0.86 [0.60-0.96]) and time to reach 90% MVC (ICC 0.8 [0.53-0.93]) and poor reliability for dorsiflexor RFD200ms (ICC 0.79 [0.48-0.92]). Conclusion: Given the functional significance of the ankle dorsiflexors, future research should investigate more reliable methods for measuring rapid force production in the dorsiflexor muscles after stroke.
Lygia Clark (1920-1988) 100 anos - resenha de uma exposição
Authors: Sousa Cristina de Jesus , De Oliveira Maria Liz Cunha 
Published: April 2023

Resumo: A resenha analisa a exposição Lygia Clark 100 anos que aconteceu no Rio de Janeiro, tendo sido curador Max Perlingeiro, que apresentou as várias fases do processo criativo da artista em uma seleção de 100 obras. Palavras-chave: Lygia Clark; exposição; artista; curadoria Lygia Clark (1920-1988) 100 years - review of an exhibition Abstract: The review analyzes the exhibition Lygia Clark 100 years that took place in Rio de Janeiro, having been curator Max Perlingeiro, who presented the various phases of the creative process of the artist in a selection of 100 works. Keywords: Lygia Clark; exhibition; artist; curadorship.
A palliative nursing strategy to enhance communication and support for patients and families in intensive care units
Authors: O'Kane Marie , Gormley Kevin , Isaac Jolly 
Published: April 2023

Aim: There have been significant advancements in palliative nursing in health services, but less so in intensive care units (ICUs). The purpose of this literature review was to examine palliative nursing care in ICUs and consider how a nursing strategy could improve communication and support for patients and their families. Method: An exploratory literature review was conducted to evaluate and compare ICU care strategies with palliative support. The search was conducted using CINAHL Plus and Medline All databases and was limited to a 6-year period. Eight publications were selected for review and a full text review was undertaken using the Critical Appraisal Skills Programme systematic review checklist. Results: Two themes emerged around the use of palliative nursing strategies. These were: improving communication between health professionals and patients; and providing support for patients and families. Conclusions: Palliative nursing has the potential to improve the quality of communication in ICU settings and support for patients and families. Further training and preparation of nurses in palliative care would improve the patient and family experience during a critical and emotional period of health service provision.
Reescrituras del Cancionero popular infantil desde la perspectiva de género: contribución de Once damas atrevidas y Teresa la princesa a la educación literaria
Authors: Ortiz Ballesteros Antonia María , Gómez Rubio Gema 
Published: April 2023

Este trabajo analiza el proceso de reescritura y recodificación por el que dos canciones populares de tradición infantil han sido recientemente transformadas en sendos álbumes ilustrados líricos que se presentan como un recurso privilegiado a la hora de desarrollar tanto la educación literaria de los jóvenes lectores como su sentido crítico ante representaciones estereotipadas del género. El objetivo es que ambas obras sirvan como ejemplo de la vigencia que el Cancionero popular infantil sigue teniendo en nuestros días, así como de las posibilidades didácticas que ofrecen las reescrituras de la tradición oral para desarrollar una educación literaria basada en el dialogismo, la creatividad y el pensamiento crítico.
Hybrid SWM-IR narrow bandpass filters with high optical density
Authors: He Xin , Shen Xiaoming , Beckett Paul , Xiao Duo , Liu Xu , Yin Rui 
Published: April 2023

Narrow bandpass filters (NBFs), which are designed to accept a narrow wavelength range and simultaneously reject a much wider range, show great potential in applications such as spectral imaging, lidar detection, fluorescence microscopy, and others. In this paper, we propose and numerically simulate NBF technology for infrared (IR) optical applications. The filter is a combination of plasmonic nanostructures and improved induced transmission layers. The operating wavelength range is from 1360 to 5000 nm [short wave mid-infrared radiation(SWM-IR)], with a FWHM of less than 10 nm and maximum optical density of around 10. Therefore, our SWM-IR hybrid filter can distinguish much smaller differences in terms of spectrum information and reduce the background noise level even if using an optical amplifier.
Human monkeypox infection threat: A comprehensive overview
Authors: Kang Yue , Yu Yue , Xu Silu 
Published: April 2023

Background
In addition to the COVID-19 waves, the globe is recently facing global monkeypox (MPX) outbreak. As the daily confirmed cases of MPX infection across epidemic and nonepidemic countries are increasing, taking measures to control global pandemic remains crucial. Therefore, this review aimed to provide fundamental knowledge for the prevention and control of future outbreaks of this emerging epidemic.

Methods
The review was conducted using PubMed and Google Scholar databases; the search terms used were “monkeypox,” “MPX tropism,” “replication signaling of MPX,” “biology and pathogenicity of MPX,” “diagnosis of MPX,” “treatment of MPX,” “prevention of MPX,” etc. The update epidemic data were collected from the websites of the World Health Organization (WHO), United States Centers for Disease Control and Prevention (CDC), and Africa Center for Disease Control and Prevention (ADCC). High-quality research results published in authoritative journals were summarized and preferred cited. Excluding all duplicates, non-English published references, and irrelevant literature, totally 1,436 articles were assessed for eligibility.

Results
It is still difficult to diagnose the patient as MPX simply based on clinical manifestations; therefore, under this situation, employing polymerase chain reaction (PCR) technology to provide confirmed evidence for the diagnosis of MPX seems to be the preferred and indispensable strategy. The treatment approach for MPX infection is mainly symptomatic and supportive; anti-smallpox virus drugs including tecovirimat, cidofovir, and brincidofovir can be employed in severe cases. Timely identification and isolation of confirmed cases, cutting off dissemination routes, and vaccination of close contacts are effective measures to control MPX. Also, smallpox vaccines (JYNNEOS, LC16m8, and ACAM2000) can be under consideration due to their immunological cross-protection among Orthopoxvirus. Nevertheless, given the low quality and scarcity of relevant evidence of current antiviral drugs and vaccines, deeply seeking for the MAPK/ERK, PAK-1, PI3K/Akt signaling, and other pathways involved in MPX invasion may provide potential targets for the treatment, prevention, and control of the epidemic.

Conclusions
In response to the current MPX epidemic, the development of vaccines and antiviral drugs against MPX, as well as the rapid and precise diagnostic methods are still urgently needed. Sound monitoring and detection systems should be established to limit the rapid spread of MPX worldwide.
The use of artificial intelligence and machine learning methods in early pregnancy pre-eclampsia screening: A systematic review protocol
Authors: Hedley Paula L. , Hagen Christian M. , Wilstrup Casper , Christiansen Michael 
Published: April 2023

Introduction
Pre-eclampsia (PE) is a leading cause of perinatal morbidity and mortality worldwide. Low-dose aspirin can prevent PE in high risk pregnancies if started early. However, despite intense research into the area, early pregnancy screening for PE risk is still not a routine part of pregnancy care. Several studies have described the application of artificial intelligence (AI) and machine learning (ML) in risk prediction of PE and its subtypes. A systematic review of available literature is necessary to catalogue the current applications of AI/ML methods in early pregnancy screening for PE, in order to better inform the development of clinically relevant risk prediction algorithms which will enable timely intervention and the development of new treatment strategies. The aim of this systematic review is to identify and assess studies regarding the application of AI/ML methods in early pregnancy screening for PE.

Methods
A systematic review of peer-reviewed as well as the pre-published cohort, case-control, or cross-sectional studies will be conducted. Relevant information will be accessed from the following databases; PubMed, Google Scholar, Scopus, Embase, Web of Science, Cochrane Library, Arxiv, BioRxiv, and MedRxiv. The studies will be evaluated by two reviewers in a parallel, blind assessment of the literature, a third reviewer will assess any studies in which the first two reviewers did not agree. The free online tool Rayyan, will be used in this literature assessment stage. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 checklist will be used to guide the review process and the methods of the studies will be assessed using the Newcastle-Ottawa scale. Narrative synthesis will be conducted for all included studies. Meta-analysis will also be conducted where data quality and availability allow.

Ethics and dissemination
The review will not require ethical approval and the findings will be published in a peer-reviewed journal using the PRISMA guidelines.

Trial registration
Trial registration: The protocol for this systematic review has been registered in PROSPERO [CRD42022345786]. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022345786.
Comparison of active tuberculosis case finding strategies for immigrants in South Korea: Epidemiology and cost-effectiveness analysis
Authors: Park Sangwook , Sung Chaegyu , Choi Hangseok , Lee Yeo Wool , Kang Yedham , Kim Hee-Jin , Kim Hae-Young , Oh In-Hwan , Lee Seung Heon 
Published: April 2023

Background
Tuberculosis (TB) is one of the serious infectious diseases in South Korea, with 49 new cases per 100,000 people and 629 multi-drug resistant (MDR) cases reported in 2020. TB is increasing among immigrants in S. Korea, and various TB case finding strategies are being performed for screening. We compared active case finding (ACF) with passive case finding (semi-PCF) across epidemiological characteristics and investigated a cost-effective strategy for screening immigrants for TB.

Methods
ACF driven by non-governmental organizations and semi-PCF as part of the government’s visa renewal process using CXR with additional acid-fast bacilli (AFB) smear and cultures were performed. Epidemiological parameters were compared between the two TB screening projects, and costs were collected. Cost-effectiveness was evaluated using a decision analysis model from the health system perspective. The primary outcome was incremental cost-effectiveness ratio (ICER) per averted TB case. Additional probabilistic sensitivity analysis was conducted.

Results
ACF (2.02%) showed a higher TB prevalence rate than semi-PCF (0.67%) on CXR. For subjects older than 60 years, the suspected TB rate on CXR was significantly higher in ACF (36.6%) than in semi-PCF (12.2%) (P<0.01). TB incidence among the family visa type was significantly higher in ACF (1.96%) than in semi-PCF (0.88%) (P < 0.0012). Costs for ACF ($666.92) were $20.784 higher than for semi-PCF ($646.13), but TB progression decreased by 0.02, resulting in an ICER of $948.18 per averted TB case. In sensitivity analysis, the indirect costs of ACF and semi-PCF had the highest impact on ICER.

Conclusion
ACF found more TB cases than semi-PCF through CXR screening, and suspect cases with old age and family visa type were more common in ACF than in semi-PCF. ACF is cost-effective as a TB screening strategy for immigrants.