bluuebunny/crossref_metadata_2025_split huggingface dataset:
High endothelial venule is a prognostic immune‐related biomarker in patients with resected intrahepatic cholangiocarcinoma
Authors: Zhou Yan , Gu Qian , Zhu Linxi , Zhang Shuo , Wu Hongyan , Pu Xiaohong , Jiang Chunping , Chen Jun 
Published: July 2023

AbstractHaving been reported to be a crucial prognostic factor in solid tumours, the role of high endothelial venule (HEV) in intrahepatic cholangiocarcinoma (ICC) remains unclear, however. The data of ICC and healthy individuals were downloaded from the Gene Expression Omnibus (GEO), and The Cancer Genome Atlas (TCGA) databases. Meanwhile, a cutting‐edge ICC high‐resolution spatial transcriptome was also acquired before these data were comprehensively analysed using bioinformatics approaches. Moreover, 95 individuals with ICC who had undergone resection surgery were enrolled in this study to investigate the relationship between HEV and tumour microenvironment (TME) applying immunohistochemistry and multiple immunofluorescence techniques. The high‐HEV subtype contains rich immune infiltrates including tertiary lymphoid structure (TLS), CD8+ T cells, and CD20+ B cells. Furthermore, HEV and TLS exhibited a strong relationship of spatial colocalization. Correlated with improved prognostic outcomes in ICC, the high‐HEV subtype could be an independent prognostic indicator for individuals with ICC. This study revealed the association of HEV with immune function and observed a strong spatial colocalization correlation between HEV and TLS. Moreover, correlated with immunotherapeutic response, HEV could improve prognostic outcomes, which may be a potential indicator of immunotherapy pathology in ICC.
Stigma: The Shaming Model
Authors: Allison Euan 
Published: July 2023

AbstractAccording to a dominant view of stigma, a person is stigmatized within a community if sufficiently many people within that community hold a bad view of her. I call this the ‘Bad View Model’. In this paper, I argue against the Bad View Model on the grounds that such beliefs are neither necessary nor sufficient for stigma, and that the account cannot explain the distinctive phenomenology of stigma, including certain vulnerabilities to shame. I then develop an alternative that explains these features of stigma, which I call the ‘Shaming Model’. On this view, a person is stigmatized within a community if she is shamed by members of that community, and this is explained by their belief that she has deviated from some social norm and/or standard.
Histopathological characterization of cerebral small vessel disease in epilepsy patients with temporal lobe epilepsy submitted to surgery: A case–control study
Authors: Coelho Pedro , Madureira João , Franco Ana , Peralta Ana Rita , Bentes Carla , Campos Alexandre Rainha , Anink Jasper , Aronica Eleonora , Roque Rafael , Pimentel José 
Published: July 2023

AbstractBackgroundCerebrovascular disease (CVD) is a major contributor to epilepsy; however, patients with epilepsy also have a significantly increased risk of stroke. The way in which epilepsy contributes to the increased risk of stroke is still uncertain and is ill‐characterized in neuropathological studies. A neuropathological characterization of cerebral small vessel disease (cSVD) in patients with chronic epilepsy was performed.MethodsThirty‐three patients with refractory epilepsy and hippocampal sclerosis (HS) submitted to epilepsy surgery from a reference center were selected between 2010 and 2020 and compared with 19 autopsy controls. Five randomly selected arterioles from each patient were analyzed using a previously validated scale for cSVD. The presence of CVD disease imaging markers in pre‐surgical brain magnetic resonance imaging (MRI) was studied.ResultsThere were no differences in age (43.8 vs. 41.6 years; p = 0.547) or gender distribution (female gender 60.6% vs. male gender 52.6%; p = 0.575) between groups. Most CVD findings in brain MRI were mild. Patients had a mean time between the epilepsy onset and surgery of 26 ± 14.7 years and were medicated with a median number of three antiseizure medication (ASMs) [IQR 2–3]. Patients had higher median scores in arteriolosclerosis (3 vs. 1; p < 0.0001), microhemorrhages (4 vs. 1; p < 0.0001) and total score value (12 vs. 8.9; p = 0.031) in comparison with controls. No correlation was found between age, number of years until surgery, number of ASMs or cumulative defined daily dosage of ASM.ConclusionThe present study provides evidence supporting the increased burden of cSVD in the neuropathological samples of patients with chronic epilepsy.
The coconut rhinoceros beetle (Oryctes rhinoceros) outbreak is well established on Efate, Vanuatu
Authors: Paudel Sulav , Jackson Trevor A. , Boulekouran Sylvie , Tasale Jeffline , Garae Bill , Allanson Patricia , Ero Mark , Marshall Sean D. G. 
Published: July 2023

AbstractThe presence of coconut rhinoceros beetle (CRB: Oryctes rhinoceros) was reported on Efate, Vanuatu in 2019. The beetle population was determined to belong to the CRB‐S group (Clade II), similar to populations found in the Bismark Archipelago, Papua New Guinea. An introduction of the CRB‐G group (Clade IA) was discovered in 2021. Damage mapping, beetle trapping and genomic identification show that CRB‐S has now spread around about half of the island from the site of the original introduction. CRB‐G is mainly restricted to the seaport and surrounding areas of Port Vila with some outlying specimens. Through the efforts of Biosecurity Vanuatu, O. rhinoceros is still contained on the Efate group of islands and has not spread to the major copra‐producing islands in other parts of the country. Sanitation efforts appear to have reduced damage from coconut rhinoceros beetle within the zone of first arrival of the pest (Mangaliliu, Efate). Oryctes rhinoceros damage, however, is severe in areas with old plantations and limited sanitation activities (e.g. Mele/Devil's point, Efate). A concerted effort is necessary to contain the beetle on Efate and to reduce further spread and impact on the island.
Near‐infrared radiation causes sebaceous gland enlargement along with an ROS‐dependent augmentation of epidermal growth factor receptor expression in hamsters
Authors: Tanaka Shiho , Sakaue Hiroaki , Koiwai Toshikazu , Okuda Natsuki , Okuyama Katsuki , Horioka Yoshihiko , Hiramatsu Yasunari , Kawashima Makoto , Ishiguro Naoko , Sato Takashi 
Published: July 2023

AbstractAs near‐infrared radiation (NIR), which is a composition of sunlight with an 780–1400 nm wavelength, is associated with skin aging such as wrinkles and slacks, the biological actions of NIR with high dermal penetration remains unclear. In the present study, we found that NIR irradiation (40 J/cm2) at different levels of irradiance (95–190 mW/cm2) using a laboratory device with a xenon flash lamp (780–1700 nm) caused sebaceous gland enlargement concomitantly with skin thickening in the auricle skin of hamsters. The sebaceous gland enlargement resulted from the proliferation of sebocytes due to an increase in the number of proliferating cell nuclear antigen (PCNA)‐ and lamin B1‐positive cells in vivo. In addition, NIR irradiation transcriptionally augmented the production of epidermal growth factor receptor (EGFR) accompanied with an increase in the reactive oxygen species (ROS) level in hamster sebocytes in vitro. Furthermore, the administration of hydrogen peroxide increased the level of EGFR mRNA in the sebocytes. Therefore, these results provide novel evidence that NIR irradiation causes the hyperplasia of sebaceous glands in hamsters by mechanisms in which EGFR production is transcriptionally augmented through ROS‐dependent pathways in sebocytes.
The therapeutic alliance in couple therapy: Patterns by treatment and sex in a randomized controlled trial of emotionally focused therapy and treatment as usual
Authors: Fang Meng , Morgan Preston , Yzaguirre Melissa M. , Tseng Chi‐Fang , Wittenborn Andrea K. 
Published: July 2023

AbstractThe formation and development of the therapeutic alliance in couple therapy is a complex process and a key contributor to positive treatment outcomes. This study explored differences in trajectories of therapeutic alliance by sex and treatment condition among 24 couples randomized to receive Emotionally Focused Therapy or treatment as usual. The results identified a curvilinear growth pattern for alliance across both treatment groups. Female partners reported higher alliance than male partners after the first session across treatment groups, and female partners receiving Emotionally Focused Therapy reported higher initial alliance than female partners receiving treatment as usual. The rates of change for alliance did not differ by sex or treatment condition. The implications of the change pattern and differences in alliance formation by sex and treatment are discussed.
Coparenting support in the context of difficult children: Mother and father differences
Authors: Johnson Victoria J. , Choi Dongho , Wheeler Lorey A. , Kuo Patty X. 
Published: July 2023

AbstractWhile parenting children with difficult behaviors can intensify stress within the entire family system, families may lean on other familial relationships to mitigate that stress. The coparenting relationship is known to play a key role within the family system for child outcomes and familial interactions, but it is not clear whether it eases the stress and challenge of raising a difficult child, nor how that plays out differently for mothers versus fathers. Ninety‐six couples (89.7% married) parenting young children (Mean age = 3.22 years) were included in this study. Using cross‐sectional and aggregated daily response data, actor–partner interdependence models were used to examine how mothers' and fathers' perceived coparenting support lessened or intensified parenting stress and/or daily problems with their child/children—for themselves or their parenting partner. We found that greater coparenting support reported by mothers coincided with stronger links between the mother's report of child difficulty and daily problems encountered by both mothers and fathers. In contrast, when fathers reported greater coparenting support, the intensity between reported child difficulty and daily problems decreased for mothers, and fathers reported lower parenting stress. Coparenting support also moderated associations between parents' perception of child difficulty and daily problems with their children. These results suggest that mothers incur heightened coparenting support from fathers when experiencing more difficult child behavior and that coparenting support experienced by fathers may alleviate parenting challenges for mothers. These findings further contribute to the literature by emphasizing distinct differences between mothers and fathers in coparenting associations within the family system.
Fracture toughness of a rigid polyurethane foam: experimental and numerical investigation by varying the specimen sizes
Authors: Vantadori Sabrina , Carpinteri Andrea , Cerioni Roberto , Ronchei Camilla , Scorza Daniela , Zanichelli Andrea , Marsavina Liviu 
Published: July 2023

AbstractIn the present paper, the fracture toughness of a polyurethane (PUR) foam (manufactured by Necumer GmbH, Germany, under the commercial designation Necuron 651) is experimentally and numerically investigated in order to examine its dependence on the specimen sizes. As a matter fact, to the best knowledge of the present authors, such an analysis is still missing in the technical literature. To perform the experimental campaign, notched PUR foam beams, with different geometrical sizes, are tested under three‐point bending loading, and the Modified Two‐Parameter Model (recently proposed by some of the present authors) is employed to measure the fracture toughness. Subsequently, such an experimental campaign is numerically simulated by applying a micromechanical model, implemented in a non‐linear finite element homemade code. Finally, the results obtained are compared with some experimental data available in the literature, related to the same PUR foam.
Influence of pre‐strain and bake hardening on the static and fatigue strength of a DP600 steel sheet
Authors: Kusch Andrea , Crivelli Daniele , Diviani Luca , Dotta Matteo , Salamina Simone , Berto Filippo 
Published: July 2023

AbstractThe influence of pre‐strain on the tensile and fatigue properties of a dual phase DP600 steel was studied. The material was pre‐strained by uni‐axial tension in rolling and transverse direction. Thereafter, specimens were cut from the deformed plates in parallel or orthogonal to pre‐strain direction. It was found that pre‐strain increases yield and tensile strength. Results suggested that strain path change primarily affects the elastic‐plastic transition during early stage of reloading. Pre‐strained specimens showed an increase in high cycle regimes as a consequence of yield strength increment, irrespective of imposed pre‐straining direction. A modified stress life equation that accounts for pre‐strain was proposed and showed good agreement with experimental data. Bake hardening enhanced both tensile and high cycle fatigue resistance. Walker equation was successfully fitted to account for tensile mean stress. In low cycle fatigue, negligible influence of pre‐strain was observed due to cyclic softening and residual stress relaxation.
Estimating contagion mechanism in global equity market with time‐zone effect
Authors: Wu Boyao , Huang Difang , Chen Muzi 
Published: July 2023

AbstractThis paper proposes a time‐zone vector autoregressive (VAR) model to investigate comovements in the global financial market. Analyzing daily data from 36 national equity markets, we explore the subprime and European debt crises using static analysis and the COVID‐19 crisis through a rolling window method. Our study of comovements using VAR coefficients reveals a resonance effect in the global system. Findings on densities and assortativities suggest the existence of the transmission mechanism in all periods and abnormal structural changes during the crises. Strength analysis uncovers the information transmission mechanism across continents over normal and turmoil periods and emphasizes specific stock markets' unique roles. We examine dynamic continent strengths to demonstrate the contagion mechanism in the global equity market over an extended period. Incorporating the time‐zone effect significantly enhances the VAR model's interpretability. Signed networks provide more information on global equity markets and better identify critical contagion patterns than unsigned networks.
Development of a haemophilia A gene therapy shared decision‐making tool for clinicians
Authors: Limjoco Jacqueline , Thornburg Courtney D. 
Published: July 2023

AbstractIntroductionAs gene therapies are incorporated into clinical practice, shared decision‐making (SDM) is recommended for implementation.AimTo inform development of a clinician SDM tool for haemophilia A gene therapy.MethodsClinicians at US Hemophilia Treatment Centers completed semi‐structured interviews about their experience with SDM and provided feedback on a clinician SDM tool prototype. Interviews were transcribed verbatim for coding and thematic content analysis.ResultsTen participants enrolled, eight physicians and two haemophilia nurses. All participants care for adults with haemophilia (1‐27 years of experience) and 7 have gene therapy trials open at their institution. Confidence in having a clinical discussion about gene therapy included none (N = 1), slight (N = 3), moderate (N = 5) and high (N = 1). All participants reported familiarity with SDM and agreed that the tool would be useful for their clinical practice. Key themes in participant feedback for the tool were (1) language and presentation; (2) content; and (3) implementation. Participants highlighted the importance of providing unbiased information and having companion tools with patient‐centric language.ConclusionThese data highlight the need for SDM tools for haemophilia A gene therapy. Key information to include in the tool are safety, efficacy, cost and detailed information on the gene therapy process. Data should be provided in an unbiased format and allow comparison to other treatments. The tool will be evaluated in clinical practice and refined as clinical trial data and real‐world experience mature.
BUSINESS CYCLES WITH CYCLICAL RETURNS TO SCALE
Authors: Hyun Jay , Kim Ryan , Lee Byoungchan 
Published: July 2023

AbstractWe study business cycles with cyclical returns to scale. Contrary to tightly parameterized conventional production functions, we empirically identify strong input complementarity that leads to procyclical returns to scale. We, therefore, propose a flexible translog production function that allows complementarity‐induced procyclical returns to scale. We integrate this function into a standard medium‐scale dynamic stochastic general equilibrium model. Our estimated model with input complementarity (i) features procyclical returns to scale and acyclical price markups, (ii) better matches the cyclicality of factor shares, and (iii) significantly decreases the contribution of markup shocks to output fluctuations relative to those of the standard model.
Optimal growth with labor market frictions
Authors: Guerrazzi Marco 
Published: July 2023

AbstractIn this paper, I build a capital accumulation model in which labor has to be alternatively employed in the production of goods or in the recruitment of workers. Within this setting, I show that (i) the intensive measure of capital may converge towards its stationary value in a non‐monotonic manner, (ii) Pareto‐optimal allocations can also be achieved in a decentralized environment in which the wage is indexed to labor market tightness, and (iii) the consistency of the wage that implements efficient allocations with the competitiveness of the market for goods relies on vanishing values of the discount rate.
The value of blockchain technology in supply chains with capital constraints: from the perspective of demand volatility
Authors: Zhu Shichao , Li Jian , Wang Yajing , Li Yongwu , Dong Xuefan 
Published: July 2023

AbstractBlockchain technology (BCT) has the potential to revolutionize the supply chain financing (SCF) system and mitigate the detrimental effects of demand volatility on SCF. As one of the first to examine the effects of BCT implementation in SCF from the perspective of demand volatility, we focus on the impacts of BCT on equilibrium and whether the retailer has the incentive to adopt BCT. We perform a comparative analysis of the Stackelberg game involving three parties under scenarios with and without BCT adoption. We find that when the demand volatility reduction coefficient is sufficiently large, BCT can facilitate a reduction of the ordering quantity while still sustaining the same service level, thus avoiding excessive inventory, and reducing the associated risk of bankruptcy. Additionally, the decreased bankruptcy risk enabled the bank to reduce interest rates. The adoption of BCT can improve the profit of the retailer when the adoption cost of BCT is sufficiently low. Our findings provide management insights into when the small and medium‐sized enterprises should adopt BCT and the interactive decision‐making of all parties in the SCF business after BCT adoption.
Operational research models for green technology cross‐licensing with known carbon quota trading prices
Authors: Zhang Qi , Li Yuwei , Lin Gui‐Hua , Zhu Xide 
Published: July 2023

AbstractGreen finance contributes significantly to the openness and transparency of carbon quota trading prices, which is conducive to the development of green technology innovation. With known carbon quota trading prices, we construct game‐based operational research models to analyze fixed‐fee and mixed‐fee cross‐licensing strategies for green technologies between two competing firms under the cap‐and‐trade policy. We compare the equilibrium outcomes of no‐licensing, fixed‐fee, and mixed‐fee cross‐licensing strategies. The findings reveal that product pricing under the fixed‐fee cross‐licensing strategy is beneficial to consumers. The mixed‐fee cross‐licensing strategy is optimal in terms of firms' total profits. When the degree of product substitutions is large and the improvement in carbon emissions is small, firms are more inclined to the no‐licensing strategy. We further introduce the revenue‐sharing contract, which can extend the Pareto improvement domain and improve the performance of green technology cross‐licensing strategies.
Playing the long game: Carrying out principled tests of psychological phenomena before developing formal theories
Authors: Burke Sara Emily , Moss‐Racusin Corinne A. 
Published: July 2023

AbstractSome participants in the conversation about changing scientific norms have recommended that researchers articulate detailed, formalized theories from the outset. Also, leading psychology journals have historically prioritized research that conveys at least the appearance of a satisfying theoretical conclusion. We argue that simply demonstrating social phenomena is a vital component of the theory‐generation process itself, and that it is counterproductive to require authors to derive all predictions from established theoretical frameworks. Our point goes beyond calling for descriptive and exploratory research: much can be learned by carrying out carefully formulated confirmatory tests of a phenomenon before claiming to know its relationship with past or future theories. The heart of science is the practice of subjecting ideas to systematic, transparent tests, regardless of whether those ideas stem from broad, thoroughly articulated theories or provisional reasoning about phenomena. Publication standards that require definitive theoretical or practical conclusions incentivize hasty ones. We need researchers playing the long game, so we need outlets for research that has not fully established what is going on and why. This special issue aimed to provide such an outlet.
Insecticide application using an unmanned aerial vehicle for Diaphorina citri control in citrus orchards
Authors: Miranda Marcelo Pedreira , Eduardo Wellington Ivo , Scapin Marcelo da Silva , Volpe Haroldo Xavier Linhares , Rodriguez Guilherme Maniezo , Vizoni Moacir Celio , Hakvoort Regina Bernardina Johanna 
Published: July 2023

AbstractThe use of unmanned aerial vehicles (UAVs) combined with other methods to spray insecticides may be a useful technique for controlling Diaphorina citri Kuwayama (Hemiptera: Psyllidae) and consequently managing Huanglongbing. Therefore, this study was conducted to assess the efficacy of insecticide application using a UAV for D. citri control in citrus orchards of 1, 4 and 12 years old. In addition, spray deposition was assessed using copper as a marker. Seedlings of sweet orange were attached on the inner canopy and on the outer canopy of citrus trees before spraying insecticide or copper. An additional experiment was performed to assess the effect of 6 and 10 m spray swaths in the 4‐year‐old orchard. Ten adult psyllids were confined to each sprayed seedling. Untreated seedlings were used as a control. The first psyllid confinement was performed 4 h after spraying insecticide. The second, third and fourth confinements were performed 7, 14 and 21 days, respectively, after spraying. In general, insecticide application using a UAV resulted in psyllid mortality higher than 80% after the first and second confinements, regardless of the orchard age and seedling position on the citrus tree (inner or outer). There were no significant differences in D. citri mortality between the spray swaths assessed. Spray deposition on leaves was higher in the outer canopy than in the inner canopy of citrus trees. This study demonstrated, for the first time, the efficacy of insecticide application using a UAV for D. citri control in citrus orchards of different ages. These results broaden the prevailing perspectives on the use of UAVs as complements to ground spraying for psyllid management.