bluuebunny/crossref_metadata_2025_split huggingface dataset:
The longer-term impact of the COVID-19 pandemic on wellbeing and cognitive functioning of older adults
Authors: De Pue Sarah , Gillebert Céline , Dierckx Eva , Bussche Eva Van den 
Published: January 2023

Abstract
In earlier survey research, we observed a severe impact of the first peak of the COVID-19 pandemic on the subjective wellbeing, sleep and activity of adults aged 65 years or older in Flanders, Belgium. The impact on subjective cognitive functioning, however, was limited. Since then, periods of lockdown and periods with less strict regulations alternated, but social distancing remained, especially for older adults. To study the longer-term impact of the pandemic on wellbeing and cognitive functioning, we re-assessed the older adults from the first measurement moment (n = 371) in a second (June-July 2020) and third (December 2020) wave of the survey. Results indicated that wellbeing fluctuated with the severity of the pandemic. Results for self-reported cognitive functioning were mixed. While participants indicated a slightly better general cognitive functioning at the end of the study, experienced problems with most cognitive subdomains significantly increased over time. The presence of depressive and anxiety symptoms influenced the longer-term impact of the pandemic on wellbeing and cognitive functioning. Our study shows the long-lasting impact of the pandemic on the wellbeing and cognitive functioning of older adults, without full recovery from the first wave.
ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer
Authors: Kanai Ryo , Uehara Takeshi , Yoshizawa Takahiro , Kamakura Masato , Nakajima Tomoyuki , Kinugawa Yasuhiro , Iwaya Mai , Asaka Shiho , Kitazawa Masato , Nagaya Tadanobu , Ota Hiroyoshi 
Published: January 2023

Abstract
Background: ADP-ribosylation factor-like protein 4C (ARL4C) is a member of the ARF small GTP-binding protein subfamily. The ARL4C gene is highly expressed in colorectal cancer (CRC). ARL4Cprotein promotes cell motility, invasion, and proliferation.
Methods: We investigated the characteristics of ARL4Cby comparing its expression at the invasion front and relationshipswith clinicopathological data using RNAscope, a highly sensitive RNA in situmethod.
Results: In all cases, ARL4Cexpression was observed in both cancer stromal cells and cancer cells. ARL4Cexpression in cancer cells was localized at the invasion front. In cancer stromal cells, ARL4C expression was significantly stronger in cases with high-grade tumor budding than in cases with low-grade tumor budding (P=0.0002). Additionally, ARL4C expression was significantly increased in patients with highhistological grade compared with those with lowhistological grade (P=0.0227). Furthermore, ARL4C expression was significantly stronger in lesions with the epithelial-to-mesenchymal transition (EMT) phenotype compared with the non-EMT phenotype (P=0.0289). In CRC cells, ARL4C expression was significantly stronger in cells that had the EMT phenotype compared with those with a non-EMT phenotype (P=0.0366). ARL4C expression was significantly higher in cancer stromal cells than in CRC cells (P<0.0001).
Conclusion: Our analysis reinforces the possibility that ARL4Cexpression worsens prognosis. Further elucidation of the function of ARL4Cis desired.
Prognostic value of pretreatment FDG PET-CT for short-term efficacy of radioactive iodine-125 seed implantation in patients with NSCLC
Authors: Hu Tianpeng , Shen Jie , Shao Menglin , Feng Xuemin , Lu Dongyan , Ding Enci 
Published: January 2023

Abstract
Objective: To analyze the short-term clinical effect of radioactive iodine-125 seed implantation (125I-SI) for non-small cell lung cancer (NSCLC) patients and explore the correlation between the related metabolic parameters of pretreatment FDG PET-CT and the short-term efficacy of 125I-SI in patients with NSCLC, so as to provide useful reference for 125I-SI treatment.
Methods: Retrospective analysis was performed on 46 patients with NSCLC, who received 125I-SI treatment for lung tumors in Tianjin First Central Hospital from January 2016 to December 2018. The correlation among D90, gender, pathological pattern, age, maximum tumor diameter, MTV, SUVmax, SUVpeak, SUVmean, TLG, High metabolic tumor cell ratio (HMR) and CEA with short-term efficacy of 125I-SI was analyzed by two independent-sample t-test, Mann-Whitney U-test or Chi-squared test and binary logistic regression.
Results: One month after 125I-SI, 0 cases were CR, and 4 cases were PR, and the total effective rate was 8.7%. After 3 months, there were 2 cases of CR, and 25 cases of PR, with a total effective rate of 58.7%; after 6 months, there were 5 cases of CR, and 27 cases of PR, with a total effective rate of 69.6%. D90 (P = 0.028, OR:1.075,95%CI:1.008-1.147), MTV (P = 0.026, OR: 0.918,95%CI: 0.851-0.990), HMR (P = 0.020, OR: 0.003,95%CI: 0-0.407) were independent predictors for the short-term efficacy. The predictable accuracy of MTV was medium (AUC=0.781; cutoff value=44.58). However, the predictable accuracy of D90 and HMR was low, with both AUC of 0.650 (the cutoff =127.8Gy and the cutoff=0.27, respectively).
Conclusion: 125-SI is an effective therapy with few complications in NSCLC patients. Small MTV, high D90 and low HRM were linked with better local control of 6 months after 125-SI.
Portal venous blood flows determine liver function in patients with decompensated cirrhosis due to HCV infection receiving successful sofosbuvir/velpatasvir therapy
Authors: Uchida Yoshihito , Imai Yukinori , Tsuji Shohei , Uemura Hayato , Kouyama Jun-ichi , Naiki Kayoko , Ando Satsuki , Sugawara Kayoko , Nakao Masamitsu , Nakayama Nobuaki , Mizuno Suguru , Tomiya Tomoaki , Mochida Satoshi 
Published: January 2023

AbstractAim: To determine the significance of the portal venous blood flow and portosystemic shunts in patients with decompensated cirrhosis due to HCV infection following SVR achievement.Methods: Portal hypertension-related events and liver function were evaluated in 27 patients during and after sofosbuvir/velpatasvir therapy.Results: SVR was achieved in 25 patients, and the outcome was evaluated in 24 patients. Serum albumin level (median; g/dL) increased from 2.9 at baseline to 3.5 at 12 weeks after EOT, while liver volumes (cm3) decreased from 1,260 to 1,150. The cumulative occurrence rates of portal hypertension-related events after EOT were 29.2%, 33.3%, and 46.1% at 24, 48, and 96 weeks, respectively. Multivariate logistic regression analysis revealed that the maximal diameter of the shunts was associated with the event development, with a cutoff value of 8.3 mm. Multiple linear regression analysis revealed that portal venous blood flow, liver volume, serum albumin and bilirubin levels at baseline were associated with serum albumin levels at 12 weeks after EOT.Conclusion: In patients with decompensated cirrhosis caused by HCV, the baseline portal venous blood flow and liver volume and function were predictive of liver function following SVR, while the size of portosystemic shunts predicted the portal hypertension-related event occurrence.
A Study on the Mechanisms of Digital Transformation Affecting Total Factor Productivity of Firms: Evidence from Chinese Heavy Polluting Listed Companies
Authors: Su Jinqi , Wei Yinying , Wang Shubin , Liu Qilei 
Published: January 2023

Abstract
In the era of digital economy, the relationship between digital transformation and total factor productivity of enterprises has a profound impact on the high-quality development of enterprises. Heavy polluting enterprises are given more environmental responsibilities due to their high pollution and high emission characteristics. This paper analyzes the theoretical framework of the impact of digital transformation on total factor productivity of heavy polluting enterprises, and explores the impact mechanism of digitalization of heavy polluting enterprises on total factor productivity of enterprises with a sample of heavy polluting enterprises in Shanghai and Shenzhen A-shares from 2010 to 2020. It is found that the digital transformation of heavy polluting enterprises can effectively improve the total factor productivity of enterprises, internally by improving the level of green technological innovation and externally by enhancing the willingness and ability of corporate social responsibility. It is further found that the digital transformation of state-owned, non-manufacturing, high level of environmental protection investment and large heavy polluting enterprises has a more significant increase in total factor productivity. The findings of the study provide empirical evidence for the digital transformation of heavy polluting enterprises to improve productivity and the green transformation of the economy by enterprises under the dual carbon target.
“We don’t need no education” – A qualitative study of barriers to continuous medical education among Danish general practitioners
Authors: Ibsen Helle , Lillevang Gunver , Søndergaard Jens , Kjaer Niels Kristian 
Published: January 2023

Abstract
Background: Continuous medical education is essential for the individual patient care, the society, and the wellbeing of the general practitioner. There has been research into the reasons for participation in continuous medical education, but little is known about the barriers to participation. To be able to tailor continuous medical education to general practitioners who are currently deselecting education, we require systematic knowledge of the barriers.
Continuous medical education can stimulate job satisfaction, diminish burnout, and reinforce feelings of competence. Delayed retirement is seen among general practitioners who thrive in their job. General practitioners’ mental well-being may have positive implications for their patients and for healthcare expenditures. Educational activities show promise as a strategy to recruit and retain physicians in less attractive specialties.
Despite renumeration and a comprehensive continuous education model not all Danish general practitioners participate in continuous medical education.
Methods: 243 out of a total of 3440 Danish general practitioners did not apply for reimbursement for accredited continuous medical education in a two-year period. 10 general practitioners were selected for an interview regarding maximum variation in practice form, number of listed patients, seniority as a general practitioner, geography, gender, and age. All 10 selected general practitioners accepted to be interviewed. The interviews were analysed using Systematic Text Condensation.
Results: Each of the 10 interviewed general practitioners mentions several barriers for participating in continuous education. The barriers fall into three main categories:
· barriers related to the individual general practitioner
· barriers related to the clinic
· barriers related to the accredited continuous medical education offered
Conclusions: Less than 7% of the Danish general practitioners did not participate in accredited remunerated continuous medical education. It corresponds to 400.000 listed patients having a general practitioner who does not participate in accredited continuous education. The barriers for participating fall into three main categories. A knowledge of the barriers for participating in accredited continuous medical education can be used to better target continuous medical education to some of the general practitioners who are currently deselecting continuous education.
Gliomatosis cerebri with blindness mimicking herpes simplex encephalitis: a case report with literature review
Authors: Jahanshahi Amirreza , Salarinejad Sareh , Oraee-Yazdani Saeed , Chehresonboll Yasaman , Morsali Soroush , Jafarizadeh Ali , Jaberinezhad Mehran , Falahatian Masih 
Published: January 2023

Abstract

Background Gliomatosis cerebri (GC) is a rare diffuse infiltrative growth pattern of gliomas presenting with unspecified clinical manifestations. Herpes simplex encephalitis (HSE) is a central nervous system (CNS) viral infection, usually involving temporal lobes, that can lead to acute or sub-acute cerebral dysfunction. Differentiating these entities is necessary for patients with misleading presentations and imaging findings. To the best of our knowledge, this is the first case of glioma mimicking herpes encephalitis, which has complicated by blindness. Case Presentation The patient was a 35 years-old male in a drug rehabilitation center for heroin addiction. He presented with a headache, a single episode of seizure, and a two-month history of bilateral decrease in visual acuity, which had acutely worsened. Magnetic resonance imaging (MRI) and computed tomography (CT) showed bilateral temporal lobe involvement, which when combined with the patient's demographic and history, led to empirical treatment for herpes simplex encephalitis being commenced. Unfortunately, no improvement in visual acuity was detected following this treatment. Ophthalmological studies showed bilateral papilledema, absence of visual evoked potential, and thickening of the retinal nerve fiber layer. Due to the atypical clinical presentation, normal laboratory data, and suspicious MRI findings, further investigation with magnetic resonance spectroscopy (MRS) was performed. Results showed a greatly increased ratio of choline to creatinine or N-acetyl aspartate (NAA), suggesting a possible neoplastic nature of the disease. Subsequently, the patient was referred for a brain tissue biopsy with a suspicion of malignancy. The pathology results revealed adult-type diffuse glioma with isocitrate dehydrogenase (IDH) mutation. Conclusion When presented with a young patient displaying acute or sub-acute neurological symptoms and bilateral temporal lobe involvement on MRI, it is common for clinicians to presume HSE or another viral encephalitis as the primary differential diagnosis. However, as demonstrated in this study, neoplastic lesions such as adult-type diffuse glioma must be considered, especially when the clinical and imaging findings are not completely typical for HSE.
Simulation based Single cell and Multi Cell Monitoring Management with SOC &amp; SOH Control for Continuous working of Electric Vehicle/ Grid Connected System
Authors: V Kandaswamy K , B Raj Narain 
Published: January 2023

Abstract
Electric vehicles (EVs) and smart grids are two examples of high-power applications that frequently use lithium-ion pack and a battery management system (BMS). Battery status estimation, defect detection, monitoring, and control functions are required for BMS implementations, which require both software and hardware. Predicting battery life aids in the consistent and efficient operation of battery-powered equipment. The proposed method uses Portable and continuous monitoring of the battery life to prevent from sudden discharge, High temperature with frequent charging and discharging system. Voltage, current, and temperature sensors are used to detect the voltage, current, and temperature of the cells. The controller receives the data from each sensor connected at different node gives the update continuously to the monitor. Similarly, the controller prevents the battery from over discharge and under discharge of each cell. Apart from regular monitoring and controlling of each cell, a novel method is proposed in the existing circuit for partial or full charging during idling condition. Monitoring the battery state continuously allows for balanced charging of the battery cells and overcharge prevention. The suggested concept includes a Graphical User Interface (GUI), a method for training a model, and test results for the BMS.
Validation of a Harmonic Acoustic Model for Duct-borne Noise &amp; Vibration onboard Maritime Vessels
Authors: Nagarkar Atharva , Chaudhari Rajesh , Das Arnab 
Published: January 2023

Abstract
Noise & Vibration studies are one of the most important aspects of designing any dynamic system. Any machinery which has components having high inertia, rotating components, friction, losses and other random forces create excitations at various locations. Ducts are an excellent carrier of various types of vibrations which are created by these excitation forces and carry them to various locations. Thus, if excessive noise levels are generated and transmitted to different ship locations, there are possibilities of detrimental effects such as hearing disabilities for crew and passengers onboard, failure of equipments due to resonance, noise emission to surroundings, violation of stealth requirements etc. This paper primarily focuses on understanding the sources of noise & vibrations onboard marine vessels, transmission of these vibrations to various locations on ships via ducts and attenuation of the noise. Using the guidelines established by various classification societies such as American Bureau of Shipping, Bureau Veritas, Lloyd’s Register etc., a package written in Python is developed to calculate the theoretical attenuation across the duct system for a case under consideration. A harmonic acoustic model is created in ANSYS (R2022) software to replicate this noise & vibration scenario onboard ships for various duct subsystems. After the simulation is carried out, a comparison of the output of the Python package and ANSYS model is carried for attenuation of noise levels. This provides a basis for establishing the accuracy of the simulated model. It is found that the error is minimal and the 2 output results are in sync. Thus, this enables us to further improve these models for various ships and ensure the noise levels are restricted within the required limits.
Cropping system has stronger effect on Tobacco soil bacterial community than fertilization
Authors: Jin Xiufeng , Yang Xiaoqian , Peng Shuang , Ma Erdeng , Zhang Hong , Lin Xiangui , Wang Yiming , Li Junying 
Published: January 2023

Abstract
Purpose Soil microorganisms are involved in many key processes in the soil ecosystem, including nutrition cycling, organic matter turnover, and soil structure maintenance. However, their responses to fertilization and different tillage systems in tobacco soils remain poorly understood.
Methods In this study, we conducted a 19-year-long field experiment on rice-tobacco rotation cropping (R) and continuous tobacco cropping (C) with three treatments, i.e., no fertilizer (NF), chemical NPK fertilizer (NPK), and compost pig manure (OM). The composition, co-occurrence patterns, nitrogen cycle process of the bacterial communities and the soil properties were analyzed in the soils after tobacco was harvested.
Results The pH and AK in the group R soil were markedly lower than those in group C, the α-diversity index, and number of N-cycling genes were opposite. The phyla Chloroflexi, Desulfobacterota, MBNT15, and Nitrospinota, as well as number of low-abundancegenera, were significantly enriched in the rotation system. PICRUSt2 showed that the functional amino acid biosynthesis pathway, tricarboxylic acid cycle, and nucleic acid metabolism were significantly higher in group R than in group C. The application of OM in group C significantly increased the contents of soil nutrients and N-cycling genes, further changing the structure of the soil bacterial community. PERMANOVA suggested that variations in the bacterial communities and functions were more attributed to tillage systems than to fertilization practices.
Conclusion After 19 years of cultivation, the effect of tillage on bacterial communities in tobacco soil was greater than that of fertilization. Together, these findings increase our understanding of the importance of land management and fertilization in shaping the soil bacterial of tobacco.
Students' Psychic Health Differs Significantly from Their Mental Health
Authors: Kwatra Ishita 
Published: January 2023

Abstract
The disparity in students' psychological and mental health was the focus of this research. Both male and female students were included in the sample size of 240 students (120 men and 120 women). The Psychological Well Being Scale was used as the technique for measuring happiness in the study (PWBS). Which was developed by Professor S.N. Rai; the "Mental Health Battery" used to assess it was created by researchers A.K. Singh and Alpana Sen Gupta. As a result of a recent study that measured students' psychological and mental health, researchers discovered that male and female students' psychological and mental health fare differently.
Single-cell analysis reveals novel clonally expanded monocytes associated with IL1β-IL1R2 pair in acute inflammatory demyelinating polyneuropathy
Authors: Li Meng , Song Jihe , Yin Pengqi , Chen Hongping , Wang Yingju , Xu Chen , Jiang Fangchao , Wang Haining , Han Baichao , Du Xinshu , Wang Wei , Li Guozhong , Zhong Di 
Published: January 2023

Abstract
Guillain-Barré syndrome (GBS) is an autoimmune disorder wherein the composition and gene expression patterns of peripheral blood immune cells change significantly. It is triggered by antigens with similar epitopes to Schwann cells that stimulate a maladaptive immune response against peripheral nerves. However, an atlas for peripheral blood immune cells in patients with GBS has not yet been constructed. Herein, we performed single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from healthy donors and patients with acute inflammatory demyelinating polyneuropathy (AIDP) at the peak and convalescent stages. Our study identified a novel clonally expanded CD14+ CD163+ monocyte subtype in the peripheral blood of patients with AIDP, and it was enriched in cellular response to IL1 and chemokine signaling pathways. Furthermore, we observed increased IL1β-IL1R2 cell-cell communication between CD14+ and CD16+ monocytes. In short, by analyzing the single-cell landscape of the PBMCs in patients with AIDP we hope to widen our understanding of the composition of peripheral immune cells in patients with GBS and provide a theoretical basis for future studies.