bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization design of interdigitated microelectrodes with an insulation layer on the connection tracks to enhance efficiency of assessment of the cell viability
Authors: Sherif Sameh. , Ghallab Yehya H. , AbdelRaheem Omnia , Ziko Laila , Siam Rania , Ismail Yehea 
Published: May 2023

Abstract
Background
Microelectrical Impedance Spectroscopy (µEIS) is a tiny device that utilizes fluid as a working medium in combination with biological cells to extract various electrical parameters. Dielectric parameters of biological cells are essential parameters that can be extracted using µEIS. µEIS has many advantages, such as portability, disposable sensors, and high-precision results.

Results
The paper compares different configurations of interdigitated microelectrodes with and without a passivation layer on the cell contact tracks. The influence of the number of electrodes on the enhancement of the extracted impedance for different types of cells was provided and discussed. Different types of cells are experimentally tested, such as viable and non-viable MCF7, along with different buffer solutions. This study confirms the importance of µEIS for in vivo and in vitro applications. An essential application of µEIS is to differentiate between the cells’ sizes based on the measured capacitance, which is indirectly related to the cells’ size. The extracted statistical values reveal the capability and sensitivity of the system to distinguish between two clusters of cells based on viability and size.

Conclusion
A completely portable and easy-to-use system, including different sensor configurations, was designed, fabricated, and experimentally tested. The system was used to extract the dielectric parameters of the Microbeads and MCF7 cells immersed in different buffer solutions. The high sensitivity of the readout circuit, which enables it to extract the difference between the viable and non-viable cells, was provided and discussed. The proposed system can extract and differentiate between different types of cells based on cells’ sizes; two other polystyrene microbeads with different sizes are tested. Contamination that may happen was avoided using a Microfluidic chamber. The study shows a good match between the experiment and simulation results. The study also shows the optimum number of interdigitated electrodes that can be used to extract the variation in the dielectric parameters of the cells without leakage current or parasitic capacitance.
Prenatal detection of Kaposiform Hemangioendothelioma with Kasabach–Merritt phenomenon: a case report
Authors: Maurya Vinay , Sharma Shweta , Singh Samarjeet , Sharma Pankaj , Gupta Amul 
Published: May 2023

Abstract
Background
Kaposiform Hemangioendothelioma is a rare vascular neoplasm that typically presents in neonates and infancy. Most of the cases of Kaposiform Hemangioendothelioma are reported in neonates (60%) and infancy (93%), and very few cases have been reported prenatally. We describe here a case which was diagnosed prenatally in the 3rd trimester with rapid growth of upper limb and appearance of non-immune hydrops.

Case presentation
A 25-year-old primigravida, an antenatally booked case, presented for routine third trimester level III scan at 34-week gestation. Level I scan for nasal bone and nuchal translucency at 12 weeks and level II anomaly scan at 20 weeks were normal. Level III ultrasound scan revealed increased echogenicity and hypertrophy of soft tissues of right upper limb and trunk involving both the subcutaneous and muscular compartments. Fetal middle cerebral artery Doppler, echocardiography and magnetic resonance imaging revealed fetal anemia, cardiac failure, and non-immune hydrops. These findings with hemodynamic changes and rapid evolution were suggestive of Kaposiform Hemangioendothelioma with Kasabach–Merritt phenomenon.

Conclusion
The diagnosis of Kaposiform Hemangioendothelioma should be suspected in prenatal period if there is unilateral hypertrophy of limb which has evolved rapidly over a short interval of time and shows findings suggestive of Kasabach–Merritt Phenomenon. Prenatal presentation is life threatening if it is associated with poor fetal hemodynamics. Prenatal counseling in such cases should include advice on termination of pregnancy with emphasis on neonatal management.
Correlation between the perineural invasion and neck metastasis in patients with laryngeal carcinoma: a cross sectional study
Authors: Hamela Mo’men Ali , Bestawy Ahmed , Gharib Fadi 
Published: May 2023

Abstract
Background
One of the most problematic issues of laryngeal carcinoma is recurrence after surgery one of the causes of recurrence this study tries to find its relevance is the peri neural invasion.

Aim of the work
To determine whether there is a relationship between perineural invasion and cervical nodal metastases of laryngeal squamous cell carcinoma.

Methods
Between December 2019 and September 2020, this study was conducted on 30 individuals who had laryngeal SCC. After the surgical removal of the tumor, a histological examination was done to check for the existence of perineural invasion, which was later linked to the cervical nodal metastases.

Results
Of our patients 26.7% (8/30) had perineural invasion. Perineural invasion and cervical nodal metastasis were statistically significantly associated (P value = 0.018).

Conclusion
A strong histologic predictor of cervical nodal metastases is perineural invasion.
Rationale and clinical application of antimicrobial stewardship principles in the intensive care unit: a multidisciplinary statement
Authors: Cortegiani Andrea , Antonelli Massimo , Falcone Marco , Giarratano Antonino , Girardis Massimo , Leone Marc , Pea Federico , Stefani Stefania , Viaggi Bruno , Viale Pierluigi 
Published: May 2023

Abstract

Background
Antimicrobial resistance represents a major critical issue for the management of the critically ill patients hospitalized in the intensive care unit (ICU), since infections by multidrug-resistant bacteria are characterized by high morbidity and mortality, high rates of treatment failure, and increased healthcare costs worldwide. It is also well known that antimicrobial resistance can emerge as a result of inadequate antimicrobial therapy, in terms of drug selection and/or treatment duration. The application of antimicrobial stewardship principles in ICUs improves the quality of antimicrobial therapy management. However, it needs specific considerations related to the critical setting.

Methods
The aim of this consensus document gathering a multidisciplinary panel of experts was to discuss principles of antimicrobial stewardship in ICU and to produce statements that facilitate their clinical application and optimize their effectiveness. The methodology used was a modified nominal group discussion.

Conclusion
The final set of statements underlined the importance of the specific interpretation of antimicrobial stewardship’s principles in critically ill patient management, quasi-targeted therapy, the use of rapid diagnostic methods, the personalization of antimicrobial therapies’ duration, obtaining microbiological surveillance data, the use of PK/PD targets, and the use of specific indicators in antimicrobial stewardship programs.
Endocrine Therapy for Primary and Secondary Prevention After Diagnosis of High-Risk Breast Lesions or Preinvasive Breast Cancer
Authors: Laws Alison , Punglia Rinaa S. 
Published: May 2023

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology , to patients seen in their own clinical practice. Patients with high-risk breast lesions (HRLs) or preinvasive breast cancers face an elevated risk of future breast cancer diagnoses. Endocrine therapy in this setting reduces the risk of a future diagnosis but does not confer improved survival, thus the side effects of primary/secondary prevention must be considered relative to the benefits. Here, we discuss the available chemoprevention regimens for patients with HRLs and considerations for selecting a regimen, as well as the decision making surrounding use of adjuvant endocrine therapy for patients with ductal carcinoma in situ (DCIS). For patients with HRLs, available chemoprevention regimens differ by menopausal status, including tamoxifen 20 mg once daily for 5 years and more recently tamoxifen 5 mg once daily for 3 years in both premenopausal and postmenopausal women as well as raloxifene or aromatase inhibitors for postmenopausal women. We recommend a shared decision-making approach with attention to patient preferences related to risk tolerance and side-effect profiles. Low-dose tamoxifen appears to be a particularly favorable choice that is well tolerated, without risk of serious adverse events and offers comparable risk reduction to other regimens. For DCIS, the benefit of endocrine therapy in addition to radiation is small, and appears to be driven mainly by a reduction in contralateral breast diagnoses or new breast cancers. A strategy that reduces the side-effect profile of chemoprevention such as low-dose tamoxifen may be especially appealing in the setting of secondary prevention.
Closing the Testing Gap: Standardization of Comprehensive Biomarker Testing for Metastatic Non–Small-Cell Lung Cancer in a Large Community Oncology Practice
Authors: Waterhouse David M. , Ward Patrick , Arnal Suzzette , Neubauer Marcus , Drosick David R. , Davies Dan , Mendenhall Molly A. 
Published: May 2023

PURPOSE: Non–small-cell lung cancer (NSCLC), the leading cause of cancer death in the United States, accounts for 85% of all lung cancer cases. Biomarker testing is an integral part of the care of patients with NSCLC. Despite broad consensus recommendations that all patients with metastatic NSCLC (mNSCLC) undergo comprehensive biomarker testing (comprehensive genomic profiling and PD-L1), testing rates remain suboptimal. METHODS: The primary goal of this project was to apply National Comprehensive Cancer Network (NCCN) guidelines for comprehensive biomarker testing to all new patients with mNSCLC within a large community practice. Plan-Do-Study-Act methodology was used, with cycle 1 focused on provider education and the creation of a mNSCLC initial consult Note (electronic health record template/McKesson iKnowMed G2) and accompanying order set. Staging, template/order set utilization, and comprehensive biomarker testing rates were recorded while workflow processes were monitored. Cycle 2 centered on improved cancer staging, data analytic reporting, auditing, and reeducation. RESULTS: The comprehensive biomarker testing rates increased from a historic rate of 68% to 92.7% during the 1-year intervention period. The template utilization rate was 71% with complete staging (TNM stage and relevant biomarkers) documented in 40%. CONCLUSION: Implementation and standardization of comprehensive biomarker testing of patients with mNSCLC in a large multisite community-based oncology practice is feasible and results in significant improvement in comprehensive biomarker testing and reporting. Establishing reliable and measurable tracking metrics to ensure that these new processes are used and maintained can assist in scaling these processes. Efforts to scale this best practice are planned across the US Oncology Network.
Five-year migration and insert wear of uncemented tibial components with either conventional polyethylene or sequentially annealed highly crosslinked polyethylene inserts: a blinded randomized controlled trial using radiostereometric analysis
Authors: de Ridder Ruud , Kaptein Bart L. , Pijls Bart G. , Nelissen Rob G. H. H. , Kaptijn Herman H. 
Published: May 2023

AimsThe primary objective of this study was to compare the five-year tibial component migration and wear between highly crosslinked polyethylene (HXLPE) inserts and conventional polyethylene (PE) inserts of the uncemented Triathlon fixed insert cruciate-retaining total knee arthroplasty (TKA). Secondary objectives included clinical outcomes and patient-reported outcome measures (PROMs).MethodsA double-blinded, randomized study was conducted including 96 TKAs. Tibial component migration and insert wear were measured with radiostereometric analysis (RSA) at three, six, 12, 24, and 60 months postoperatively. PROMS were collected preoperatively and at all follow-up timepoints.ResultsThere was no clinically relevant difference in terms of tibial component migration, insert wear, and PROMs between the HXLPE and PE groups. The mean difference in tibial component migration (maximal total point migration (MTPM)) was 0.02 mm (95% confidence interval (CI) -0.07 to 0.11), which is below the value of 0.2 mm considered to be clinically relevant. Wear after five years for HXLPE was 0.16 mm (95% CI 0.05 to 0.27), and for PE was 0.23 mm (95% CI 0.12 to 0.35). The mean difference in wear rate was 0.01 mm/year (95% CI -0.02 to 0.05) in favour of the HXLPE group. Wear is mainly present on the medial side of the insert.ConclusionThere is no clinically relevant difference in tibial component migration and insert wear for up to five years between the HXLPE conventional PE inserts. For the implant studied, the potential advantages of a HXLPE insert remain to be proven under clinical conditions at longer-term follow-up.Cite this article: Bone Joint J 2023;105-B(5):518–525.
Willingness to use electronic medical record (EMR) system and its associated factors among health professionals working in Amhara region Private Hospitals 2021, Ethiopia
Authors: Senishaw Andualem Fentahun , Tilahun Biniyam Chakilu , Nigatu Araya Mesfin , Mengiste Shegaw Anagaw , Standal Karen 
Published: May 2023

Introduction
Despite the high expectations of electronic medical records as a great prospect for improving performance in healthcare, the level of adoption and utilization, particularly in a developing country, is low. Knowing the willingness to use the electronic medical record system in the private hospital has an impact on the future implementation status and utilization of the electronic medical record in Ethiopia. However, there was no evidence of the status of the willingness to use electronic medical record systems in private hospitals in the Amhara region. This study aimed to assess the willingness to use electronic medical record Systems and its associated factors among health professionals working in Amhara Region Private Hospitals.

Methods
A cross-sectional institutional study was performed among 406 health professionals selected using proportional allocation with a simple random sampling technique in Amhara region private hospitals by using self-administered structured questionnaires. The data were analyzed using SPSS version 20 software. Descriptive statistics and binary logistic regression were performed to estimate the crude and adjusted odds ratios with a 95% Confidence interval.

Results
Out of the 406 participants included in the analysis, 307 (75.6%) showed a willingness to use the electronic medical record system. About three hundred twelve (76.8%) health professionals had good knowledge of electronic medical record systems, and 257 (63.3%) had good computer skills in electronic medical record systems. Health professionals who had electronic medical record knowledge (AOR = 1.85, 95% CI (1.004–3.409)), EMR training (3.29, 95% CI (1.353–8.003)), technical support personnel (1.92, 95% CI (1.122–3.305)), supportive supervision (AOR = 1.97, 95% CI (1.072–3.628)), and computer skill on electronic medical record (1.77, 95% CI (1.002–3.148)) were significantly associated with the outcome variable.

Conclusions
This finding shows a good proportion of willingness to use the electronic medical record system. The most significant factors associated with willingness to use the electronic medical record system were a lack of computer skills, computer training, and knowledge of the electronic medical record system.
Mapeamento de pesquisas brasileiras sobre o livro didático de ciências e a base nacional comum curricular
Authors: Hensing Nilles Jéssica , De Andrade Leite Fabiane 
Published: May 2023

O presente texto tem como objetivo identificar aspectos que caracterizam as pesquisas brasileiras que abordam o Livro Didático de Ciências no contexto atual de implementação da Base Nacional Comum Curricular na Educação Básica. Por meio de uma pesquisa de natureza qualitativa utilizou-se como objeto teses e dissertações disponíveis na Biblioteca Digital Brasileira de Teses e Dissertações. A busca teve como descritores: “Base Nacional Comum; Livro Didático; e Ensino Ciências”. O levantamento ocorreu no mês de abril de 2021 e foram identificados seis trabalhos, sendo todos do tipo dissertação, que apresentam aproximação com o objetivo proposto no estudo. O processo de análise de conteúdo possibilitou organizar três categorias: Contexto da pesquisa, Natureza da pesquisa e Enfoque da pesquisa; e, com isso, subcategorias que contribuem para caracterizar. Os resultados apontam que os estudos foram realizados a partir de 2018, ano em que a versão final da Base Nacional Comum Curricular foi publicada. Além disso, destaca-se um maior número de estudos realizados em universidades no nordeste brasileiro, também, para pesquisas com foco em estudos documentais e, ainda, observou-se uma prevalência em investigações que tratam de conhecimentos-conteúdos de Ciências apresentados nos Livros Didáticos e na Base Nacional Comum Curricular. Nos estudos realizados em Livros Didáticos que correspondem ao Programa Nacional do Livro e do Material Didático anterior a 2019 evidencia-se a necessidade de adaptação dos Livros Didáticos aos documentos curriculares e há indicação de certo distanciamento entre o que está nos Livros Didáticos de Ciências e o que está na proposta dos documentos oficiais. Já os Livros Didáticos analisados nos estudos após o Programa Nacional do Livro e do Material Didático de 2019 percebe-se uma preocupação sobre o processo de adequação das propostas da Base Nacional Comum Curricular nestes materiais.
La Formación de Profesores de Fisica en Colombia: Retos entre la regulación normatica y las posibilidades académicas
Authors: Hoyos Nelson Enrique , Castiblanco Abril Olga Lucía , Garcia Edwin German , Forero Sandra Milena , Arias Gil Vanessa 
Published: May 2023

La presente reflexión surge como síntesis de la mesa sobre “La formación de los profesores de física”, en el 11 Congreso Nacional de Enseñanza de la Física, que tuvo lugar en la Universidad de Antioquia del 11 al 14 de noviembre de 2022. El objetivo de la mesa era caracterizar los retos actuales en la formación de profesores de física, dadas las exigencias normativas, establecidas por el Ministerio de Educación Nacional y las Instituciones de Educación Superior, y la consecuente tensión con las perspectivas y construcciones teóricas que emergen desde las comunidades académicas en el campo de la didáctica de la física, así como el ideal en los programas de formación de futuros profesores de física.
Rapid Input-Output Transformation between Local Field Potential and Spiking Activity during Sensation but not Action in the Superior Colliculus
Authors: Bourrelly Clara , Massot Corentin , Gandhi Neeraj J. 
Published: May 2023

Sensorimotor transformation is the sequential process of registering a sensory signal in the environment and then responding with the relevant movement at an appropriate time. For visually guided eye movements, neural signatures in the form of spiking activity of neurons have been extensively studied along the dorsoventral axis of the superior colliculus (SC). In contrast, the local field potential (LFP), which represents the putative input to a region, remains largely unexplored in the SC. We therefore compared amplitude levels and onset times of both spike bursts and LFP modulations recorded simultaneously with a laminar probe along the dorsoventral axis of SC in 3 male monkeys performing the visually guided delayed saccade task. Both signals displayed a gradual transition from sensory activity in the superficial layers to a predominantly motor response in the deeper layers, although the transition from principally sensory to mostly motor response occurred ∼500 μm deeper for the LFP. For the sensory response, LFP modulation preceded spike burst onset by <5 ms in the superficial and intermediate layers and only when data were analyzed on a trial-by-trial basis. The motor burst in the spiking activity led LFP modulation by >25 ms in the deeper layers. The results reveal a fast and efficient input-output transformation between LFP modulation and spike burst in the visually responsive layers activity during sensation but not during action. The spiking pattern observed during the movement phase is likely dominated by intracollicular processing that is not captured in the LFP.SIGNIFICANCE STATEMENTWhat is the sequence of events between local field potential (LFP) modulation and spiking activity during sensorimotor transformation? A trial-by-trial analysis reveals that the LFP activity leads the spike burst in the superficial and intermediate layers of the superior colliculus during visual processing, while both trial-by-trial and the average analyses show that the spike burst leads the LFP modulation during movement generation. These results suggest an almost instantaneous LFP input, spike burst output transformation in the visually responsive layers of the superior colliculus when registering the stimulus. In contrast, substantial intracollicular processing likely results in a saccade-related spike burst that leads LFP modulation.
Prenatal Diagnosis, Management, and Treatment of Fetal Cardiac Disease
Authors: Sethi Neeta , Miller Stephen , Hill Kevin D. 
Published: May 2023

Abstract
Prenatal diagnosis of congenital heart disease makes it possible to optimize and coordinate care of the fetus and pregnant person. Benefits encompass the full spectrum of pre- and perinatal care, from counseling to optimization of pregnancy care and fetal intervention. Prenatal diagnosis reduces the likelihood of postnatal hemodynamic compromise and improves long-term neurodevelopmental outcomes. Despite the benefits, prenatal diagnosis rates remain suboptimal, particularly for lesions that are not seen on standard 4-chamber imaging views. Improving prenatal diagnosis rates requires education and outreach efforts targeting community practices where most initial screening occurs.