bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural brain correlates of non‐verbal cognitive ability in 5‐year‐old children: Findings from the FinnBrain birth cohort study
Authors: Pulli Elmo P. , Nolvi Saara , Eskola Eeva , Nordenswan Elisabeth , Holmberg Eeva , Copeland Anni , Kumpulainen Venla , Silver Eero , Merisaari Harri , Saunavaara Jani , Parkkola Riitta , Lähdesmäki Tuire , Saukko Ekaterina , Kataja Eeva‐Leena , Korja Riikka , Karlsson Linnea , Karlsson Hasse , Tuulari Jetro J. 
Published: August 2023

AbstractNon‐verbal cognitive ability predicts multiple important life outcomes, for example, school and job performance. It has been associated with parieto–frontal cortical anatomy in prior studies in adult and adolescent populations, while young children have received relatively little attention. We explored the associations between cortical anatomy and non‐verbal cognitive ability in 165 5‐year‐old participants (mean scan age 5.40 years, SD 0.13; 90 males) from the FinnBrain Birth Cohort study. T1‐weighted brain magnetic resonance images were processed using FreeSurfer. Non‐verbal cognitive ability was measured using the Performance Intelligence Quotient (PIQ) estimated from the Block Design and Matrix Reasoning subtests from the Wechsler Preschool and Primary Scale of Intelligence (WPPSI‐III). In vertex‐wise general linear models, PIQ scores associated positively with volumes in the left caudal middle frontal and right pericalcarine regions, as well as surface area in left the caudal middle frontal, left inferior temporal, and right lingual regions. There were no associations between PIQ and cortical thickness. To the best of our knowledge, this is the first study to examine structural correlates of non‐verbal cognitive ability in a large sample of typically developing 5‐year‐olds. The findings are generally in line with prior findings from older age groups, with the important addition of the positive association between volume / surface area in the right medial occipital region and non‐verbal cognitive ability. This finding adds to the literature by discovering a new brain region that should be considered in future studies exploring the role of cortical structure for cognitive development in young children.
From undeserving to deserving: Undocumented students’ resistance to being shut out in the transition to college
Authors: Perez Nicole A. , Ballinas Jorge 
Published: August 2023

AbstractThis study examines college access among undocumented students in Elkhart County, Indiana to understand how institutional actors are responding to revelations of their legal status. Using data from 39 life history interviews, we demonstrate how undocumented students’ transition to college can hinge on the extent to which students are deemed deserving or undeserving by institutional actors. Also, participants seek out resources for reaching college through resisting abrupt abandonment by seeking alternative sources of support to ensure their transition to college. We argue that undocumented students are much more active in this process than tends to come across in previous research.Practical TakeawaysInstitutional actors—teachers, counselors, or college administrators—can constrain or facilitate undocumented student's transitions to college at various points.Institutional actors in new immigrant communities tend to lack resources and information needed to meet the college going needs of undocumented students.When denied access or overlooked during the pursuit of higher education, undocumented students are agentic and seek out resources elsewhere.
‘I went for rehab many times and it never worked, but the harm reduction process has given me renewed hope’. Perceptions on the effectiveness of harm reduction and community‐based opioid substitution therapy
Authors: Nyashanu Tichaenzana , Scheibe Andrew , Visser Maretha 
Published: August 2023

AbstractIssue AddressedThe accessibility of opioid substitution therapy (OST), one of the recommended treatments for opioid dependence, remains low.This study sought to explore the perceived effectiveness of OST from the perspectives of peer outreach workers and OST clients in a community‐based harm reduction programme.MethodsThe research was done within the Community‐Oriented Substance Use Programme (COSUP) in Tshwane, South Africa. Fifteen peer educators (13 males and 2 females) took part in two focus group discussions. Thereafter, there were semi‐structured interviews in which 15 OST clients (11 males and 4 females) participated. A convenience cross‐sectional study was used. Interviews were audio‐recorded. Using thematic analysis, themes were examined to evaluate how OST and the harm reduction approach were perceived to contribute to the improved health status of people with opioid dependence.ResultsPeer outreach workers and COSUP clients significantly endorsed OST as an effective treatment for opioid dependence. Participants perceived greater effectiveness of OST compared to abstinence‐centred inpatient rehabilitation programmes. However, there were sentiments that more community education on OST was needed to motivate people with opioid dependence to access services and to address misconceptions about OST.ConclusionsThere is a lack of multi‐level and multi‐sectoral engagement of various stakeholders in opioid dependence services, needed to accelerate utilisation of OST services.So What?The research unpacks the need for an integrated approach to service use optimisation, and the need to evaluate the role that increased awareness and community education on harm reduction strategies can play in enhancing the utilisation of OST services.
Validation of novel DNA methylation markers in cervical precancer and cancer
Authors: El‐Zein Mariam , Cheishvili David , Szyf Moshe , Franco Eduardo L. 
Published: August 2023

AbstractWe have recently identified, using a genome‐wide approach, new methylation markers which were evaluated among various cervical intraepithelial neoplasia (CIN) grades and cervical cancer. We herein validate the methylated state of these genes in independent study populations, based on histology ascertained outcomes regardless of human papillomavirus status. CA10, DPP10, FMN2 and HAS1 (discovery set: 54 normal, 50 CIN1, 40 CIN2, 42 CIN3) were evaluated by targeted bisulfite next generation sequencing (NGS) (Illumina MiSeq platform) in 258 (training set: 100 normal, 50 CIN1, 50 CIN2, 50 CIN3, 8 cancers) and 373 (validation set: 100 normal, 57 CIN1, 61 CIN2, 53 CIN3, 102 cancers) physician‐collected samples (PreservCyt). Using targeted amplification NGS data from the training set for 94 normal and eight cancer samples, we calculated for each gene the median methylation value. These were summed and normalized to compute a four‐gene Marker Polygenic Score (MPS). We compared the relationship between MPS and progression from normal through CIN grades and cancer, separately in the training and validation sets, and tested its clinical performance via receiver‐operating characteristic curves. MPS increased with increasing CIN grade, and accurately predicted cervical cancer in the training (area under the curve, AUC = 0.9950) and validation (AUC = 0.9337) sets, comparing normal to cancer. Using the highest threshold of 100% specificity, sensitivity for detection of cervical cancer was 67.7%; whereas reducing specificity to 95% increased sensitivity to 84.3%. Further evaluation of these biomarkers is warranted in prospective studies.
Twenty‐year outcome of prevalence, incidence, mortality and survival rate in patients with malignant bone tumors
Authors: Xu Yao , Shi Fanqi , Zhang Yanting , Yin Mengfan , Han Xiuxin , Feng Jinyan , Wang Guowen 
Published: August 2023

AbstractMalignant bone tumors are a group of rare malignant tumors and our study aimed to update the recent epidemiologic estimates based on the Surveillance, Epidemiology and End Results database. Patients diagnosed with malignant bone tumors from 2000 to 2019 were included and their characteristics were retrospectively described. The limited‐duration prevalence, annual age‐adjusted incidence and mortality were calculated, and the annual percentage changes were analyzed to quantify the rate change. Finally, observed survival and relative survival rate were illustrated. Subgroup analysis across tumor type, age, gender, tumor Grade, primary tumor site and stage was also performed. As for results, a total of 11 655 eligible patients with malignant bone tumor were selected. Osteosarcoma was the most common tumor type, followed by chondrosarcoma, Ewing sarcoma and chordoma. The estimated limited‐duration prevalence of malignant bone tumors increased from 2000 (0.00069%) to 2018 (0.00749%). Steady age‐adjusted incidence was observed in all patients during the study period while the highest rate occurred in osteosarcoma. Mortality rates differed in subgroups while elder patients (older than 64 years) presented the highest mortality rate compared to other age groups. In all bone tumors, the 10‐year observed survival and relative survival rates were 58.0% and 61.9%, respectively. Chondrosarcoma patients had the best survival outcome, followed by osteosarcoma, Ewing sarcoma, chordoma and other bone tumors. In conclusion, different epidemiologic performance in incidence and mortality was observed across tumor type as well as other demographic and clinicopathological variables, which provide potential suggestion for further adjustment of medical resource.
Loss of cancer cell‐derived ADAM15 alters the tumor microenvironment in colorectal tumors
Authors: Puig‐Blasco Laia , Piotrowski Krzysztof B. , Michaelsen Signe R. , Bager Nicolai S. , Areškevičiūtė Aušrinė , Thorseth Marie‐Louise , Sun Xiao‐Feng , Keller Ulrich auf dem , Kristensen Bjarne W. , Madsen Daniel H. , Gnosa Sebastian P. , Kveiborg Marie 
Published: August 2023

AbstractTumor progression and response to treatment are highly affected by interactions between cancer cells and the tumor microenvironment (TME). Many of the soluble factors and signaling receptors involved in this crosstalk are shed by a disintegrin and metalloproteinases (ADAMs). Upregulation of ADAM15 has been linked to worse survival in cancer patients and a tumor‐promoting function both in vitro and in murine cancer models. Although ADAM15 has been involved in cell‐cell and cell‐extracellular matrix interactions, its role in the crosstalk between cancer cells and the TME in vivo remains unexplored. Therefore, we aimed to understand how ADAM15 regulates the cell composition of the TME and how it affects tumor progression. Here, we showed an upregulation of ADAM15 in tumor tissues from rectal cancer patients. Subcutaneous injection of wildtype and ADAM15‐knockout CT26 colon cancer cells in syngeneic mice confirmed the protumorigenic role of ADAM15. Profiling of tumors revealed higher immune cell infiltration and cancer cell apoptosis in the ADAM15‐deficient tumors. Specifically, loss of ADAM15 led to a reduced number of granulocytes and higher infiltration of antigen‐presenting cells, including dendritic cells and macrophages, as well as more T cells. Using in vitro assays, we confirmed the regulatory effect of ADAM15 on macrophage migration and identified ADAM15‐derived CYR61 as a potential molecular mediator of this effect. Based on these findings, we speculate that targeting ADAM15 could increase the infiltration of immune cells in colorectal tumors, which is a prerequisite for effective immunotherapy.
Australian country paper: Integrated approaches to irrigation management in the future
Authors: Parr Eddie , Hayes Peter , Vranes Momir , Walters Carl 
Published: August 2023

AbstractIrrigation in Australia expanded dramatically during the early to mid‐twentieth century under an economic and social development regime of government. This led to overallocation and overuse of many of the country's water resources to the detriment of the rivers and riverine environments. To address this degradation federal and state governments have come together to implement a range of reforms at national, basin and catchment level to return water to the rivers but not at the expense of rural communities and a range of policy reforms to implement water resource best management practice including cost recovery pricing, accuracy in measurement (resource availability and extraction). The three most significant components of these reforms are the Murray–Darling Basin Plan, the National Water Initiative and the Sustainable Rural Water Use and Infrastructure Programme (SRWUIP). These actions are complemented by infrastructure and management improvements at on‐ and off‐farm levels and examples are documented.
The cardiovascular toxicity of clozapine in embryonic zebrafish and RNA sequencing‐based transcriptome analysis
Authors: Ding Zijiao , Jia Huiting , Yang Ziqian , Yao Nan , Wang Yunyun 
Published: August 2023

AbstractClozapine (CLZ) is the most prescribed medication for treating refractory schizophrenia but is associated with significant cardiovascular toxicity. This study aimed to investigate the cardiovascular toxicity induced by CLZ using zebrafish as a model animal. For this purpose, zebrafish developed to 80‐h post‐fertilization were exposed to different CLZ concentration solutions for 24 h followed by cardiac morphological observations in yolk sac edema, pericardial edema, and blood coagulation, in addition to increased SV‐BA distance, functionally manifested as bradycardia, and decreased cardiac ejection fraction using the untreated embryos as control. At the same time, RNA sequencing was used to study the possible molecular mechanism of CLZ‐induced cardiovascular toxicity. The results indicated that compared to the control group, the experimental groups possessed a total of 5888 differentially expressed genes (DEGs), where gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment of analysis indicated that DEGs were mainly enriched in the pathways related to ion channels. These findings may provide new insights and directions for the subsequent in‐depth study of the molecular mechanism of CLZ‐induced cardiovascular toxicity.
Physicochemical and biological analysis of composite biomaterials containing hydroxyapatite for biological applications
Authors: Bańkosz Magdalena , Urbaniak Mateusz M. , Szwed Aleksandra , Rudnicka Karolina , Włodarczyk Marcin , Drabczyk Anna , Kudłacik‐Kramarczyk Sonia , Tyliszczak Bożena , Sobczak‐Kupiec Agnieszka 
Published: August 2023

AbstractBone tissue regeneration is one of the main areas of tissue engineering. A particularly important aspect is the development of new innovative composite materials intended for bone tissue engineering and/or bone substitution. In this article, the synthesis and characterization of ceramic‐polymer composites based on polyvinylpyrrolidone, poly(vinyl alcohol) and hydroxyapatite (HAp) have been presented. The first part of the work deals with the synthesis and characterization of the ceramic phase. It was demonstrated that the obtained calcium phosphate is characterized by a heterogeneity and porosity indicating simultaneously its large specific surface area. Additionally, in the wound healing test, it was shown that the obtained powder supports the regeneration of L929 cells. Next, HAp‐containing composite materials were obtained in the waste‐free photopolymerization process and characterized in detail. It was proved that the obtained composites were characterized by sorption properties and stability during 12‐day incubation in simulated physiological liquids. Importantly, the obtained composites showed no cytotoxic effect against the L929 murine fibroblasts – the cell viability was 94.5%. Then, confocal microscopy allowed to observe that murine fibroblasts effectively colonized the surface of the obtained polymer‐ceramic composites, covering the entire surface of the biomaterial. Thus, the obtained results confirm the high potential of the obtained composites in the application of bone tissue regenerative medicine.
Cardiovascular Safety in Postmenopausal Women and Men With Osteoporosis Treated With Denosumab and Zoledronic Acid: A Post‐Authorization Safety Study
Authors: Spangler Leslie , Nielson Carrie M. , Brookhart M. Alan , Hernandez Rohini K. , Stad Robert Kees , Lin Tzu‐Chieh 
Published: August 2023

AbstractOsteoporosis and cardiovascular disease are common in older adults. Treatment of osteoporosis reduces the burden of debilitating fractures; however, it is important to understand the benefit versus risk of treatment. This study evaluates the risk of stroke (ischemic or hemorrhagic) and myocardial infarction (MI) among postmenopausal women and men initiating osteoporosis treatment with denosumab (receptor activator of nuclear factor κB ligand [RANKL] inhibitor) or zoledronic acid (bisphosphonate) between October 2010 and June 2019. A retrospective cohort study employing the new user/active comparator design was conducted. Analyses were conducted separately in two national US commercial databases, MarketScan® and Optum® for reproducibility. Inverse probability of treatment and censoring weighting was employed to control for confounding and informative censoring. Cumulative risks at 6‐month, 12‐month, and 36‐month time points were calculated and adjusted risk ratios and differences (with 95% confidence intervals [CIs]) were estimated. In MarketScan® and Optum® databases, 96,611 and 73,127 patients met all study eligibility criteria, respectively. At 36 months, the risk ratio estimates (zoledronic acid referent group) were 1.22 (95% CI, 0.77–1.66) and 0.97 (95% CI, 0.63–1.32) for MI and 1.00 (95% CI, 0.61–1.40) and 0.87 (95% CI, 0.56–1.17) for stroke in MarketScan and Optum, respectively. Most of the treatment associations across the other time periods and outcomes also had 95% CIs including the null value. In these large samples of real‐world US patients, no increased risk in MI and stroke were identified for up to 36 months of treatment in denosumab users compared with zoledronic acid users. © 2023 Amgen. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
The impact of the COVID‐19 pandemic on source plasma donations
Authors: Covington Mischa L. , Voma Chesinta , Stowell Sean R. 
Published: August 2023

AbstractWhile the COVID‐19 pandemic has impacted many aspects of healthcare, including routine blood donations, the impact of COVID‐19 on the donation of source plasma critical to many aspects of patient care, including apheresis procedures, has been more difficult to define. As production of plasma‐derived medicinal products (PDMPs) can take up to a year, shortages in source plasma donations may not be immediately appreciated. Given current shortages in PDMPs, in particular albumin, we examined the impact of COVID‐19 on source plasma donations. Our data demonstrate that source plasma donations were disproportionately impacted by COVID‐19 and that these shortages remained until the latter half of 2022. Given the time delay in PDMP manufacturing, these results suggest that while source plasma donation levels are returning to pre‐pandemic levels, shortages in PDMPs may not be quickly overcome. These results also highlight the unique vulnerabilities in plasma sourcing that may continue to manifest as PDMP shortages for years to come.
Study of mechanical, optical, and thermoelectric characteristics ofBa2XMoO6(X = Zn, Cd) double perovskite for energy harvesting
Authors: Al‐Qaisi Samah , Rached Habib , Alrebdi Tahani A. , Bouzgarrou S. , Behera Debidatta , Mukherjee Sanat Kumar , Khuili Mohamed , Adam Mohamed , Verma Ajay Singh , Ezzeldien Mohammed 
Published: August 2023

AbstractThe double perovskites are become the emerging aspirant to fulfill the demand of energy. Therefore, the optoelectronic, elastic and transport characteristics of Ba2XMoO6(X = Zn, Cd) are addressed systemically. The elastic constants show the mechanical stability. The nature of Ba2ZnMoO6is brittle and Ba2CdMoO6is ductile with large values of Debye temperature covalent bonding. The electronic band structures exhibit band gaps of 2.81 and 2.98 eV, which increase their importance for optoelectronic applications. The absorption of light energy, optical loss, refractive index, polarization of light energy are addressed in the energy range zero to 14 eV. Furthermore, thermoelectric characteristics are computed against chemical potentials at 300, 600, and 900 K. The chemical potential decides the p‐type nature, with holes as majority carriers. The increasing temperature increases the power factor and figure of merit. Therefore, the optoelectronic and thermoelectric characteristics reveals the importance of studied DPs for energy applications.
Development and validation of a scale assessing parental varied responses to Chinese adolescents' negative emotions
Authors: Ding Ruyi , Liu Jin , Luo Yuhan , He Wei 
Published: August 2023

AbstractObjectivesParental responses to children's negative emotions (PRCNE) constitute a critical construct in the study of emotion socialization in children and adolescents. The objective of this research was to develop and validate a concise scale for assessing how adolescents perceive PRCNE in a Chinese context, resulting in the creation of the parental varied responses to Chinese adolescents' negative emotions (PVRCANE) scale. The PVRCANE aims to evaluate seven forms of PRCNE, including the six types encompassed by the commonly used Coping with Children's Negative Emotions Scale‐Adolescent Version (CCNES‐AV), as well as an additional, culturally specific category frequently seen in Chinese families: didactic talk and teaching.MethodsIn Study 1, a group of participants (N = 901, Mage = 13.39 years, SD = 0.92) completed the initial PVRCANE and the CCNES‐Adolescent Version. In Study 2: A separate group of participants (N = 320, Mage = 13.54 years, SD = 0.57) filled in PVRCANE and scales evaluating parental socialization goals and adolescents' depressive symptoms.ResultsIn Study 1, factor analyses showed that a four‐factor structure best fit the data, leading to the final version of the PVRCANE, which includes 35 items. PVRCANE scores exhibited good internal consistency (Omega > 0.79) and convergent validity, demonstrated by their close correlation with traditional CCNES scores. Study 2 confirmed the PVRCANE's measurement invariance for both male and female parents and demonstrated criterion validity by showing significant relationships between PVRCANE scores, parental socialization goals, and adolescents' symptoms of depression.ConclusionThe PVRCANE is a brief, valid, and reliable scale for assessing PRCNE in Chinese adolescents. The study concludes with a discussion on future directions and how this research enhances the existing literature on emotion socialization, with a particular emphasis on the scale's potential application in other cultural settings.