bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epileptogenicity of white matter lesions in cerebral small vessel disease: a systematic review and meta-analysis
Authors: Doerrfuss Jakob I. , Hebel Jonas M. , Holtkamp Martin 
Published: June 2023

Abstract
Background
The epileptogenic properties of white matter lesions (WML) in cerebral small vessel disease (CSVD) are not yet understood. The aim of our systematic review and meta-analysis was to estimate the association between the extent of WML in CSVD and epilepsy, analyze whether these WML are associated with an increased risk of seizure recurrence, and evaluate if treatment with anti-seizure medication (ASM) is justified in first-seizure patients with WML and no cortical lesions.

Methods
Following a pre-registered study protocol (PROSPERO-ID CRD42023390665), we systematically searched Pubmed and Embase for relevant literature comparing WML load between patients with epilepsy and controls as well as studies on seizure recurrence risk and ASM therapy in the presence vs. absence of WML. We calculated pooled estimates using a random effects model.

Results
Eleven studies comprising 2983 patients were included in our study. Presence of WML (OR 2.14, 95% CI 1.38–3.33) and presence of relevant WML as assessed by visual rating scales (OR 3.96, 95% CI 2.55–6.16) but not WML volume (OR 1.30, 95% CI 0.91–1.85) were significantly associated with seizures. These results stayed robust in sensitivity analyses restricted to studies on patients with late-onset seizures/epilepsy. Only two studies assessed the association between WML and risk of seizure recurrence with conflicting results. Currently, there are no studies on the efficacy of ASM therapy in the presence of WML in CSVD.

Conclusions
This meta-analysis suggests an association between presence of WML in CSVD and seizures. More research is needed addressing the association between WML and risk of seizure recurrence and ASM therapy focusing on a population of patients with a first unprovoked seizure.
Programmed death-ligand 1 (PD-L1) expression in cervical intraepithelial neoplasia and cervical squamous cell carcinoma of HIV-infected and non-infected patients
Authors: Brito Maria José , Sequeira Pedro , Quintas Ana , Silva Iryna , Silva Fernanda , Martins Catarina , Félix Ana 
Published: June 2023

AbstractProgrammed death-ligand 1 (PD-L1) is overexpressed in cervical carcinoma, hindering tumor destruction. The aim of this study was to assess PD-L1 expression by immunohistochemistry in cervical squamous cell carcinoma (SCC) and squamous intraepithelial lesions (SILs) from human immunodeficiency virus–positive (HIV+) and human immunodeficiency virus-negative (HIV-) patients. A total of 166 SCC and SIL samples of HIV+ and HIV- patients were included and analyzed for PD-L1 expression through tumor proportion score (TPS), and results were stratified in five TPS groups using SP263 antibody and, combined positive score (CPS) using 22C3 antibody. In cohort 1 (SP263 clone), all HIV+ patients were negative for intraepithelial lesion or malignancy (NILM), and low-grade squamous intraepithelial lesions (LSILs) scored < 1; and 87.5% of high-grade squamous intraepithelial lesions (HSILs) adjacent to SCC, 19% of HSILs non-adjacent to SCC, and 69% of SCCs scored ≥ 1 (15.4% scored 5). In HIV- patients, all NILM, LSILs, HSILs adjacent to SCC, and two HSILs non-adjacent to SCC scored < 1. SCC: 88.2% scored ≥ 1 and 5.9% scored 5. In cohort 2 (SP263 and 22C3 clones), 16.7% of HIV+ patients with SCC were positive with both clones, CPS ≥ 1 (22C3) or score 5 (≥ 50%) (SP263), showing no significant differences in positivity between both clones. These results indicate that a relatively low percentage of SCCs (16.7%; both in HIV+ and in HIV- patients) express PD-L1 (TPS ≥ 50% and CPS > 1), which may be due to some samples being archival material, sample characteristics, or use of different methodologies, highlighting the need for standardization of PD-L1 assessment in SCC of the cervix. The fact that PD-L1 is overexpressed in SILs of HIV+ patients suggests potential additional applications for immunotherapy in this disease.
Endoscopic evaluation by the Kyoto classification of gastritis combined with serum anti-Helicobacter pylori antibody testing reliably risk-stratifies subjects in a population-based gastric cancer screening program
Authors: Hirai Ryosuke , Hirai Mami , Otsuka Motoyuki , Mitsuhashi Toshiharu , Shimodate Yuichi , Mouri Hirokazu , Matsueda Kazuhiro , Yamamoto Hiroshi , Mizuno Motowo 
Published: June 2023

Abstract
Background
We previously demonstrated that the Kyoto classification of gastritis was useful for judging the status of Helicobacter pylori infection in a population-based screening program, and that adding H. pylori antibody test improved its accuracy (UMIN000028629). Here, we tested whether our endoscopic diagnosis of H. pylori infection status reliably estimated gastric cancer risk in the program.

Methods
Data were collected from1345 subjects who underwent endoscopic follow-up 4 years after the end of the registration. We analyzed the association of three diagnostic methods of H. pylori infection with gastric cancer detection: (1) endoscopic diagnosis based on the Kyoto classification of gastritis; (2) serum diagnosis according to the ABC method (H. pylori antibody and pepsinogen I and II); and (3) endoscopic diagnosis together with H. pylori antibody test.

Results
During the follow-up, 19 cases of gastric cancer were detected. By Kaplan–Meier analysis, the detection rates of cancer were significantly higher in the past or current H. pylori infection groups than in the never-infected group with all 3 methods. By the Cox proportional hazards model, the hazard ratio for cancer detection was highest in evaluation with the combined endoscopic diagnosis and the antibody test (method 3; hazard ratio 22.6, 95% confidence interval 2.99–171) among the three methods (the endoscopic diagnosis (method 1); 11.3, 2.58–49.8, and the ABC method (method 2); 7.52, 2.49–22.7).

Conclusions
Endoscopic evaluation of H. pylori status with the Kyoto classification of gastritis, especially combined with serum anti-Helicobacter pylori antibody testing, reliably risk-stratified subjects in a population-based gastric cancer screening program.
The Departure from Mixed-Layer Similarity During the Afternoon Decay of Turbulence in the Free-Convective Boundary Layer: Results from Large-Eddy Simulations
Authors: Elguernaoui Omar , Reuder Joachim , Li Dan , Maronga Björn , Paskyabi Mostafa Bakhoday , Wolf Tobias , Esau Igor 
Published: June 2023

AbstractThis study analyses the departure of the velocity-variances profiles from their quasi-steady state described by the mixed-layer similarity, using large-eddy simulations with different prescribed shapes and time scales of the surface kinematic heat flux decay. Within the descriptive frames where the time is tracked solely by the forcing time scale (either constant or time-dependent) describing the surface heat flux decay, we find that the normalized velocity-variances profiles from different runs do not collapse while they depart from mixed-layer similarity. As the mixed-layer similarity relies on the assumption that the free-convective boundary layer is in a quasi-equilibrium, we consider the ratios of the forcing time scales to the convective eddy-turnover time scale. We find that the normalized velocity-variances profiles collapse in the only case where the ratio ($$\widetilde{r}$$

r
~

) of the time-dependent forcing time scale to the convective eddy-turnover time scale is used for tracking the time, supporting the independence of the departure from the characteristics of the surface heat flux decay. As a consequence of this result, the knowledge of $$\widetilde{r}$$

r
~

is sufficient to predict the departure of the velocity variances from their quasi-steady state, irrespective of the shape of the surface heat flux decay. This study highlights the importance of considering both the time-dependent forcing time scale and the convective eddy-turnover time scale for evaluating the response of the free-convective boundary layer to the surface heat flux decay.
Using the onto-semiotic approach to analyze novice algebra learners’ meaning-making processes with different representations
Authors: Erbilgin Evrim , Gningue Serigne M. 
Published: June 2023

Abstract
Representations are key to mathematical activities and meaning-making processes as they are part of modeling, connecting, communicating, and understanding mathematical ideas and concepts. The current study sought to examine a group of novice algebra learners’ interactions with different representations from an onto-semiotic approach. A case study method was employed to understand how different algebraic practices (abstracting, generalizing, justifying, and operating on symbols) and functional thinking types (recursive, covariational, and correspondence) were facilitated through working with multiple representations. Three 6th graders participated in the study by completing 12 algebra tasks and taking part in two interviews. The onto-semiotic approach guided the data analysis process that involved the identification of mathematical objects that emerged in the participating students’ mathematical practices. Then, the configuration of objects and semiotic functions established by the students in the functional situations was examined to understand the role of representations in the students’ development of algebraic thinking and practices. Findings showed that abstraction is an essential process for generalization. Thinking about far figures facilitated abstraction and generalization through helping students construct non-ostensive concrete/pictorial representations. Verbal representations interacted with all representations and preceded symbolic representations. Working with near figures promoted recursive and covariational thinking while examining the far figures usually resulted in correspondence thinking. Implications for the school curriculum are discussed in the paper.
Bioaccessibility by perspiration uptake of minerals from two different sulfurous peloids
Authors: Bastos Carla Marina , Rocha Fernando , Patinha Carla , Marinho-Reis Paula 
Published: June 2023

AbstractThe risks associated with the use of peloids in thermal centers, spas, or at home, must be tested to develop appropriate safety guidelines for peloids formulations and the release of substances of high concern. Additionally, the beneficial effects of some elements on human health should be assessed to aid in interpreting the therapeutic action and effectiveness of pelotherapy on dermatological or osteomuscular disorders.
Therefore, a methodology was developed to better understand the biogeochemical behavior of the elements in formulated peloids. Two peloids were formulated with the same clay and two different sulfurous mineral-medicinal waters for 90 days, with light stirring every 15 days. Bentonite clay, with a high content of smectite and Ca and Mg as the main exchangeable cations, and high heat capacity, was used. The selected mineral-medicinal waters were collected from two Portuguese thermal centers with recognized therapeutic efficacy for rheumatic, respiratory and dermatological pathologies. The peloids were used without drying and withdrawn directly from the maturation tank, and a mixture of bentonite and demineralized water was prepared as a reference sample. A stabilized, ready-to-use, artificial perspiration test was used to simulate the peloids’ interaction with skin. Thirty-one elements extracted from the two prepared peloids were analyzed using ICP-MS. The data were analyzed and related to the mineralogical composition of the original clay and supernatant composition of the maturation tanks. The content of some potentially toxic elements and metals’ bioaccessibility by perspiration showed very low solubility and undetectable amounts extracted from the studied samples. This analytical method provided reliable information on dermal exposure and the identification of some elements that may enter the systemic circulation, requiring implementation of surveillance and control measures.
Graphical abstract
About the associations of vitamin D deficiency and biomarkers of systemic inflammatory response with all-cause and cause-specific mortality in a general population sample of almost 400,000 UK Biobank participants
Authors: Sha Sha , Gwenzi Tafirenyika , Chen Li-Ju , Brenner Hermann , Schöttker Ben 
Published: June 2023

AbstractIt is unknown whether the well-known association between vitamin D deficiency and mortality could be explained by the immune system modulating effects of vitamin D, which may protect from a systemic inflammatory response (SIR) to adverse health conditions. This study aims to investigate the interrelationships of vitamin D deficiency, biomarkers of SIR, and mortality. We used multivariate logistic regression with adjustment for 51 covariates to assess the associations of vitamin D deficiency with disadvantageous levels of nine biomarkers of SIR in the UK Biobank cohort. Furthermore, we tested with Cox regression and mediation analysis whether biomarkers of SIR and vitamin D deficiency were independently associated with mortality. We included 397,737 participants aged 37–73 years. Vitamin D deficiency was associated with disadvantageous levels of all blood cell count-based biomarkers, but not with C-reactive protein (CRP)-based biomarkers after adjustment for body weight. Vitamin D deficiency and all biomarkers of SIR were significantly associated with all-cause mortality and mortality from cancer, cardiovascular and respiratory disease. The strength of these associations was unaltered if vitamin D deficiency and biomarkers of SIR were put in the same model. This finding was further supported by the mediation analyses. This study showed that vitamin D deficiency is associated with disadvantageous levels of blood cell count-based but not CRP-based biomarkers of SIR. Vitamin D deficiency and systemic inflammation were independently and strongly associated with mortality. The potential of clinical interventions against both vitamin D deficiency and underlying causes of systemic inflammation should be explored.
Characterizing Attention Resource Capacity in Autism: A Multiple Object Tracking Study
Authors: Tullo Domenico , Levy Bianca , Faubert Jocelyn , Bertone Armando 
Published: June 2023

AbstractThe extant literature aimed at characterizing attentional capability in autistics has presented inconsistent findings. This inconsistency and uncertainty may be the product of different theoretical and methodological approaches used to define attention in autism. In the current study, we investigate whether the allocation of attentional resources to task demands, and attention resource capacity, differs between autistics with no comorbid attention-deficit diagnosis (n = 55) and age-matched neurotypicals (n = 55). We compared differences in capacity and the allocation of resources by manipulating attentional load in a Multiple Object-Tracking (MOT) task, a robust, versatile, and ecological measure of selective, sustained, and distributed attention. While autistics demonstrated lower MOT performance, this difference disappeared when we accounted for fluid reasoning intelligence. Additionally, the similarity in the trend of MOT performance at increasing levels of attentional load between autistics and neurotypicals suggests no differences in the allocation of attentional resources to task demands. Taken together, our study suggests that higher-order cognitive abilities, such as intelligence, should be considered when characterizing attention across the autistic population in research. Similarly, our findings highlight the importance of considering cognitive competence when assessing attentional capabilities in autistic individuals, which could have significant implications for clinical diagnosis, treatment, and support.
Large-scale diagnostic assessment in first-year university students: pre- and transpandemic comparison
Authors: Sánchez-Mendiola Melchor , Manzano-Patiño Abigail P. , García-Minjares Manuel , Casanova Enrique Buzo , Herrera Penilla Careli J. , Goytia-Rodríguez Katyna , Martínez-González Adrián 
Published: June 2023

AbstractCOVID-19 has disrupted higher education globally, and there is scarce information about the “learning loss” in university students throughout this crisis. The goal of the study was to compare scores in a large-scale knowledge diagnostic exam applied to students admitted to the university, before and during the pandemic. Research design was quasi-experimental with static group comparisons, taking advantage of the pandemic “natural experiment,” to assess knowledge in students admitted to the National Autonomous University of Mexico. Four student cohorts were analyzed: 2017 and 2018 (prepandemic, paper-and-pencil exams), 2020 and 2021 (transpandemic, online exams). The same instruments were applied in each pair of cohorts (2017–2021; 2018–2020) to decrease instrumentation threat. Propensity score matching was used to create balanced comparable groups. 35,584 matched students from each of the 2018 and 2020 cohorts were compared and 31,574 matched students from each of the 2017–2021 cohorts. Reliability and point biserial correlation coefficients were higher in the transpandemic online applications. Knowledge scores were 2.3 to 7.1% higher in the transpandemic assessments, Spanish scores in the 2018–2020 comparison were 1.3% lower, and English results in 2021 were 7.1% lower than in 2017. Before the pandemic, there was a 3.1% higher test performance in men; this gap decreased to 0.34% during the pandemic. There was no documented learning loss in this large student population, with an increase in knowledge in the pandemic cohorts. Some influence in scores due to the online testing modality cannot be ruled out. Longitudinal follow-up is required to continue evaluating the impact of the pandemic in learning.
How algorithms are reshaping the exploitation of labour-power: insights into the process of labour invisibilization in the platform economy
Authors: Cini Lorenzo 
Published: June 2023

AbstractMarx conceives of capitalism as a production mode based on the exploitation of labour-power, whose productive consumption in the labour process is considered as the main source of value creation. Capitalists seek to obscure and secure workers’ contribution to the production process, whereas workers strive to have their contribution fully recognized. The struggle between capitalists and workers over labour-time is thus central to capital’s valorization process. Hence, capital–labour antagonism is structured over the capture and exploitation of unpaid labour-time. Building on Marx’s labour value theory, as well as on some of its contemporary interpretations, I call this struggle over labour-time capture a process of ‘invisibilization’ of labour. I claim that this invisibilization process is still a relevant form of surplus-value extraction in contemporary capitalism, especially in the platform economy, characterized by remote but pervasive control by algorithms. The rediscovery of this form of surplus-value extraction and its manifestation in platform labour is the main contribution of this study. To corroborate this contribution, I compare the case of platform labour with that of textile-clothing, where value production is more clearly based on the classical forms of surplus-value extraction (i.e., absolute and relative). This comparison helps to cast a new light on the nexus between work-process transformations and surplus-value creation, which is the core of the Marxian labour theory of value, and which – I argue – is crucial to understanding contemporary capitalist developments.
Building geometry data from online maps for accurate thermal simulations of districts
Authors: Romero Rodríguez Laura , Sánchez Ramos José , Álvarez Domínguez Servando 
Published: June 2023

AbstractCurrent approaches for simulating the energy performance of buildings on a large scale are limited by numerous assumptions and simplifications, which can lead to inaccurate estimations. While new tools and procedures are emerging to improve accuracy, there remains a need for more user-friendly methods. This study proposes a new tool based on online maps to create the geometry of districts in a simple way. The tool also enables an automatic evaluation of all buildings through dynamic hourly simulations, using a building simulation software and allowing to consider different weather conditions. To illustrate the procedure, a district at risk of energy poverty in Seville (Spain) is modeled, where hourly temperature data for a whole year are available to demonstrate the need for building improvements. The tool is used to evaluate the energy demands of the district under several retrofitting alternatives, and free-floating simulations are also performed to evaluate the improvement of thermal comfort without air-conditioning systems. The aim is not to discuss the actual values for this particular case, but rather to identify the correct direction for large-scale studies, so as to make them more easily conducted. Overall, it may be concluded that the results provided by comprehensive tools, such as the one proposed in this study, enable easy yet accurate evaluations of buildings on a large scale with significant time savings, as well as the identification of locations where retrofitting interventions would have the greatest impact.
Comparison of Five Different Treatment Approaches of Mandibular Keratocystic Odontogenic Keratocyst (OKC): A Retrospective Recurrence Analysis of Clinical and Radiographic Parameters
Authors: Moellmann Henriette L. , Parviz Aida , Goldmann-Kirn Marcia , Rana Madiha , Rana Majeed 
Published: June 2023

AbstractThe odontogenic keratocyst (OKC) is a benign but locally aggressive growing lesion that infiltrates the bone and surrounding tissue. It is characterized by high rates of recurrence along with rapid growth. Different forms of partly successful treatment therapies are reported. The retrospective study at hand examined 114 patients with OKC treated over a period of 20 years. Data extracted includes gender, age, location, previous treatment for the lesion, surgery, outcome, recurrence rate and follow-up. 63.1% of the patients underwent cystectomy, 22.5% by cystectomy and carnoy solution, 7.2% by cystectomy, and curettage, 4.5% by cystostomy and 2.7% by partial resection. In this study, no significant differences could be observed regarding the surgical method. Most recurrences occurred with 91.9% in the mandible with an average size of 5.5 cm2 and increased in women. Within a mean follow-up time of 3.6 years the recurrence rate was 36.9%, on average after 36 months. Recurrences were most frequently diagnosed at the age of 31–50 (43.9%). Despite numerous studies, there is still no unanimous opinion on an effective therapy for OKC. However, precise resection of OKC can be facilitated by preoperative 3D-imaging and virtual planning.