bluuebunny/crossref_metadata_2025_split huggingface dataset:
GDF5 rs143383 and the risk of Lumbar Disc Degeneration: A Meta-analysis and Case- control study
Authors: Qi Linzeng , Chen Lu , Chang Yong , Zhu Yimin , Yang Huannning , Zhou Donglin , Wang Enjie , Wang Hongliang 
Published: May 2023

Abstract
Purpose:To verify the association between single nucleotide polymorphisms in GDF5 and lumbar disc degeneration.
Methods: A complemnetary search was peformed and related information was collected for meta analysis. And a case-control study which involving a number of 46 patients and 45 controls.
Results: There is a significant association between GDF5 rs143383 and LDD under heterozygous models in Asian. Among SNPs in GDF5, distribution of rs224329 genotype is obviously different between VAS< 4 and VAS≥ 4 groups. And the results of linkage disequilibrium analysis show a strong relationship of rs224329 and rs143383.
Conclusions: Among SNPs in GDF5, rs143383 was significantly associated with LDD in Asian, while rs224329 was considered to be related to chronic low back pain.
Impact of a Digital and Conventional Prevention Program on Work Ability, Physical Health, and Mental Health among Professionals with Initial Impairments
Authors: Schmidt Detlef , Fritsch Julian , Feil Katharina , Weyland Susanne , Jekauc Darko 
Published: May 2023

Abstract
This quasi-experimental study aimed to compare the effectiveness of a digital prevention intervention on work ability, physical health, and mental health with a conventional prevention program for professionals with initial impairments. The study recruited 245 participants, of whom 173 fully participated and completed the study, 98 (65 female, 66.3%) in the intervention group and 75 (55 female, 73.3%) in the control group. Both groups received prevention programs, with the experimental group using the Caspar digital platform and the control group using the conventional BETSI/RV Fit program. There were three measurement points in the study: T0 before the intervention, T1 in the middle of the intervention, and T2 at the end of the intervention. Participants' health was assessed using the SF-12 health status questionnaire, while their work ability was measured using the short version of the Work Ability Index. Repeated-measures analyses of variance indicated that both prevention programs were effective in improving work ability and mental health, while physical health did not show any significant improvement. Additionally, the results of the study suggest that younger individuals benefited more from the digital prevention intervention, while older individuals benefited more from the conventional prevention program. The study emphasizes the need for further research and improvements in both research and practice. Future studies should include larger sample sizes, randomized controlled trials, and follow-up assessments to enhance understanding of the effectiveness and its sustainability of prevention programs.
ERK1/2 regulates Epileptic Seizures by modulating the DRP1 mediated Mitochondrial Dynamic
Authors: Chen Ting , Yang Juan , Zheng Yongsu , Zhou Xuejiao , Huang Hao , Zhang Haiqing , Xu Zucai 
Published: May 2023

Abstract
Objective: After seizures, the hyperactivation of Extracellular signal-regulated kinases (ERK1/2) causes dysfunction of mitochondrial. Through the guideline of Dynamin-related protein 1（DRP1）, ERK1/2 plays a role in the pathogenesis of several illnesses, for instance cancer, Parkinson's, and Alzheimer's. However, it is unclear whether DRP1 function is regulated by ERK1/2 in the pathogenesis of seizures.
Method: LiCl-Pilocarpine was injected intraperitoneally to establish a status epilepticus (SE) rat for this study. Before SE induction, PD98059 and Mdivi-1 were injected intraoperatively. The number of seizures and the latency of the first seizure were then monitored. The analysis of Western blot was also used to measure the phosphorylated and total ERK1/2 and DRP1 protein expression levels in the rat hippocampus. In addition, immunohistochemistry revealed the distribution of ERK1/2 and DRP1 in hippocampal neurons CA1 and CA3.
Results: Both PD98059 and Mdivi-1 reduced rats' susceptibility to epileptic seizures, according to behavioral findings. By inhibiting ERK1/2 phosphorylation, the Western blot revealed that PD98059 indirectly reduced p-DRP1 expression level at the Ser616. Eventually, the ERK1/2 and DRP1 were distributed in the cytoplasm of neurons by immunohistochemistry.
Conclusions: p-DRP1-Ser616 expression, which may regulate the pathogenesis of epilepsy by inhibiting DRP1-mediated excessive mitochondrial fission, is downregulated when ERK1/2 signaling pathways are inhibited.
CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation
Authors: Ma Li , Zhu Xiaonan , Tang Chaoliang , Pan Peipei , Yadav Alka , Liang Rich , Press Kelly , Su Hua 
Published: May 2023

Abstract

Myeloid immune cells present abundantly in both ruptured and unruptured brain arteriovenous malformations (bAVMs). The role of central nervous system (CNS) resident and circulating monocyte-derived macrophages in bAVM pathogenesis has not been fully understood. RNA sequencing using cultured cells and bAVM samples revealed that downregulation of activin-like kinase 1 (ALK1) or endoglin (two bAVM causative genes) increased pro-angiogenic, endothelial inflammation and innate immune signaling, which provided endogenous underpinnings of the active inflammation in bAVM. To further understand the role of CNS resident macrophages in bAVM development and hemorrhage, we administrated a colony-stimulating factor 1 receptor (CSF1R) inhibitor to bAVM mice with endothelial Alk1 deletion. Transient depletion of CNS resident macrophages at early stage of bAVM development remarkably mitigated the subsequent phenotype severity of bAVM. This therapeutic effect exhibited a prolonged inhibition of angiogenesis, dysplastic vasculature formation, and infiltration of CNS resident and circulating monocyte-derived macrophages during bAVM development. Transient depletion of CNS resident macrophages also reduced the dysplasia vessels and improved the integrity of endothelial tight junctions in established bAVMs. Administration of CSF1R inhibitor also prevented severe hemorrhage of bAVMs. Thus, endothelial AVM causative gene mutation can activate CNS resident macrophages promoting bAVM progression. CNS resident macrophages could be specific targets to mitigate the development and severity of bAVMs.
Theoretical investigation of the structural evolution, electronic and magnetic properties of TMSi n − (TM= Mo, W; n = 8-17) clusters
Authors: Wang Kai , Hu Chengwei , Jia Zezhao , Yin Guangjia , Wang Runyu , Ma Lei 
Published: May 2023

Abstract
The structural evolution, electronic and magnetic properties of molybdenum and tungsten doped silicon clusters, TMSin− (TM = Mo, W; n = 8-17), have been investigated at density functional theory (DFT) level. The global minimum structure of each cluster has been searched globally based on a homemade genetic algorithm coupled with DFT calculations. The ground-state structure of each cluster has been confirmed by comparing the calculated photoelectron spectrum (PES) with the experimental one. Most sizes of MoSin− and WSin− clusters share the same geometric structures, and very similar electronic and magnetic properties. Small sized (n ≤ 13) clusters always adopt a pentagonal bipyramid TM@Si6 as the structural motif, while the larger sizes prefer a fullerene-type TM@Si14 structure. Compared to CrSin− clusters, the replacement of Cr atom by Mo and W atoms can increase the binding energy by about 0.2 eV and 0.3 eV, respectively. It also reveals that the total magnetic moments of these TMSin− (TM = Mo, W) clusters are all 1 μB, and have similar sources, but with different contributions from that of CrSin− clusters in most sizes.
Sound Absorption Polyimide Composite Aerogels for Ancient Architectures Protection
Authors: Zhao Xingyu , Hu Yujia , Xu Xiuqi , Li Mukun , Han Yixin , Huang Shan 
Published: May 2023

Abstract
Ancient architectures are an important part of immovable cultural heritage and the largest surviving amount of tangible cultural heritage in the world. However, the increasingly serious noise pollution will not only affect the sanctity of ancient architectures, but damage the internal structure caused by continuous mechanical vibration, and affect their lifetime. In this paper, diaminodiphenyl ether and pyromellitic dianhydride were used as monomers, modified by triethylamine to synthesize water-soluble polyamide acids, and calcium carbonate (CaCO3) was used as filler to prepare CaCO3/polyimide (CaCO3/PI) composite aerogels by homogeneous mixing, freeze-drying and thermal imidization. CaCO3 can effectively adjust the pore wall roughness of CaCO3/PI composite aerogels, so as to improve their sound absorption performance. When the amount of CaCO3 is 4 wt%, CaCO3/PI composite aerogels exhibit optimal sound absorption performance, excellent mechanical properties, thermal insulation and heat resistance. The corresponding noise reduction coefficient is 0.327 and the average sound absorption coefficient is 0.903 in the frequency range of 2000 ~ 6300 Hz. Young’s modulus is 4.03 kPa, stress loss and plastic deformation after 100 compression cycles with a maximum strain of 50% are 3.27% and 2.17%, respectively. The energy loss coefficient is 0.248, thermal conductivity is 0.038 W/(m·K), and heat resistance index is 334.1oC. The CaCO3/PI composite aerogels show momentous application prospects in the field of ancient architectures protection.
Impact of the degree of starch gelatinization on the texture, soaking, and cooking characteristics of high amylose rice: An experimental and numerical study
Authors: Kumari Ankanksha , Roy Anupam 
Published: May 2023

Abstract
Paddy was soaked for 8 hours at 25 ± 5 ˚C and open parboiled for varying time interval (5–60 min). Parboiled paddy was milled and studied to check the changes in hardness, color, amylose content, soaking and cooking properties. An empirical model to predict the change in hardness, color, amylose content, and cooking properties at various DG value of rice was established. Moreover, change in moisture gain, hardness, and cooking time during soaking of different DG’s rice have also been empirically correlated and modeled. The change in hardness, amylose content, cooking properties, and whiteness index followed the polynomial and power law equation with coefficient of determination (R2) greater than 0.90 and root mean square error (RMSE) less than 1. The moisture gain during soaking of milled rice with varying DG follows Weibull and Peleg model. The soaking of rice before cooking helps in reducing the cooking time which followed the 1st order kinetics with its DG. This study may be the first holistic work on the effect of rice’s DG on its soaking behavior, hardness, and cooking properties bearing significant impact in consumer preferences.
Intersectionality in cancer network: Strategies to the identification of therapeutic targets
Authors: Fadhal Emad 
Published: May 2023

Abstract
Background: Cancer is a disease that results from genetic changes disrupting normal cellular processes and as different types of cancer exhibit distinct molecular features and clinical behaviors, they also share common pathways and mechanisms. The concept of intersectionality in cancer biology refers to the overlapping sets of genes, signaling pathways, and regulatory networks that are perturbed in multiple cancer types. Understanding these intersectional networks could lead to identifying novel therapeutic targets and strategies that can be applied across different cancer types.
Results: In this study, proteins common in different types of cancers were identified to construct an intersection cancer network. The central zones within the intersection cancer network exhibit uniquely-enriched pathways, suggesting that these central zones play a crucial role in coordinating and regulating essential cellular processes across different cancer types. Additionally, pathway enrichment analysis was performed to identify common biological functions and pathways, and central zones were found to be enriched for essential proteins that regulate crucial cellular processes, including cell cycle, mRNA processing, apoptosis, and mitotic phases.
Conclusion: By understanding these intersectional networks, novel therapeutic targets and strategies can be developed that can be applied across different cancer types. Our study highlights the importance of central zones as coordinators of essential cellular processes across multiple cancers.
Epidemiology, clinical characteristics, and associated cost of acute poisoning: a retrospective study from the emergency department of the largest referral hospital in Qatar
Authors: Salem Waleed , Abdulrouf Pallivalappila , Thomas Binny , Elkassem Wessam , Abushanab Dina , Rahman Haseebur , Hanssens Yolande , Singh Rajvir , Zaki Hani , Azad Aftab Mohammed , Hail Moza Al 
Published: May 2023

AbstractIntroductionPoisoning is a major public health issue and a leading cause of admission to the emergency department (ED) worldwide. There is paucity of data describing epidemiology, outcomes, and cost of acute poisoning. Up-to-date information about poisoning pattern is imperative for accurate diagnosis and effective management. This study therefore investigates the epidemiology, poison pattern and associated cost of acute poisoning in Qatar.MethodA retrospective review of electronic health records of 397 patients admitted due to poisoning at the ED from January 2015 - December 2019. Demographic characteristics, incidence, clinical characteristics, cause of exposure, outcomes, and cost associated with acute poisoning were included. Frequency and percentages were calculated for categorical variable and mean and SD for continuous variables, relation between sociodemographic characters and poisoning profile was assessed using Chi-square. P-value less than 0.5 was considered statistically significant. A micro-costing approach using the cost of each resource was applied for the cost calculations.ResultThe incidence of acute poisoning was found to be 178 patients per 100,000 patients. Females (56%), and children below 14 years (44.3%) accounted for the largest proportion. The majority of the exposures were accidental and therapeutic agents (64.2%) were the most common toxic agents. The mean length of stay in the hospital was found to be 1.84 ± 0.81 and most patients (76.6) were discharged within the first 8 hours of the ED admission. A statistically significant difference was found between age groups and type of toxins (χ2 = 23.3, p < 0.001), cause and route of exposure (χ2 = 42.2, p < 0.001) and length of stay (χ2 = 113.16, p < 0.001). Admission to intensive care units had the highest cost expenditure (USD 326,008) while general wards accounted for the least (USD 57,709).ConclusionThe study demonstrates unintentional poisoning due to pharmacological agents was common among infants and children. The findings of this study will assist in the development of educational and preventative programs to minimise the exposure to toxic agents. Further studies exploring the impact of medical toxicology services, potential risk factors and post discharge monitoring of poisoning are highly warranted.
Carboxyhaemoglobin level in neonatal sepsis: A point of care test at paediatric emergency department
Authors: Al-Hinai Abdulhamid , Yazidi Laila Al , Jaju Sanjay , Sidairi Nasser Al , Al-Habsi Khalil , Lawati Mohammed Al , Alobeidani Saeed 
Published: May 2023

Abstract
Carboxyhaemoglobin (COHb) which represents the fraction of carbon monoxide binding to haemoglobin become available as a point-of-care test at the emergency department. Sepsis and other inflammatory process are well-known inducers of heme oxygenase enzymes that cause heme catabolism which results in endogenous carbon monoxide production. Studies have shown that measuring carboxyhaemoglobin level could be of use in early detection of neonatal sepsis.
Purpose: This study aims to assesses the rule of COHb as a biomarker for neonatal sepsis in the paediatric emergency department.
Methods: This is a retrospective case-control study that looks at the COHb values in neonates presented with febrile illness at paediatric emergency. The neonates were then categorised into culture proven bacterial infections vs culture negative bacterial infections. Different variables were then studied between the two groups.
Result: COHb levels were significantly raised at the initial presentation of neonatal sepsis regardless of gender, birth weight, or gestational age. In addition, the COHb value of ≥ 2.05 was highly specific (97.5%) for invasive bacterial infection. Moreover, the mean length of stay regardless of the final diagnosis was significantly higher in the neonate with COHb level ≥2.0 which adds a prognostic value.
Conclusion: COHb might be a useful biochemical marker for risk stratification of neonatal sepsis. Further study is needed for better delineation of its clinical utilities.
Novel Cytotoxicity Study of Strontium (Sr) Doped Iron Oxide (Fe3O4) Nanoparticles Aided with Ibuprofen for Drug Delivery Applications
Authors: Din Imad Ud , Khan Irum Shahid , Gul Iftikhar Hussain , Hussain Zakir , Miran Waheed , Javaid Farhan , Liaqat Usman 
Published: May 2023

Abstract

Purpose This work aimed to study the drug delivery applications of iron oxide (Fe3O4) nanoparticles with strontium (Sr) doping with varying molar ratios prepared by the co-precipitation route. The impact of increased strontium content on the particle size and magnetic properties was investigated. The impending of these nanoparticles for drug loading, drug release, and their respective cytotoxicity was also inspected.Methods First, iron oxide nanoparticles were doped with various amounts of strontium, from 0.25, 0.50, and 0.75, to 1 mole using co-precipitation method. These synthesized nanoparticles were characterized by XRD, SEM, EDX, VSM, and FTIR for evaluating crystal structure, phase purity, morphology, composition, magnetic properties, and functional groups, respectively. Drug loading and drug release properties were determined using UV-vis spectroscopy, whereas MTT assay evaluated cytotoxicity.Results The findings confirmed the successful doping of iron oxide with strontium via XRD and EDX. SEM results confirmed spherical morphology for all and needle-like structure for 1 mole strontium doped sample. For VSM results, a single domain structure was established. It was also observed that the drug encapsulation efficiency increases with increased strontium content. Cytotoxicity results by MTT assay revealed increased cytotoxicity with increasing nanoparticle concentration, and ibuprofen-loaded nanoparticles showed higher cytotoxicity than un-loaded nanoparticles at the same concentration.Conclusion This study provided predominantly comparison of the cytotoxicity of ibuprofen-loaded and non-loaded nanoparticles on Hep-2 cancer cells at similar concentrations for the first time for both Fe3O4 particles and Sr-doped Fe3O4 nanoparticles and enclosed the impact of increasing Sr doping content on Fe3O4 nanoparticles.
Impact of steaming and roasting heat-treatment on physico-chemical, functional and digestibility of walnut kernel
Authors: Zhao Xiaoyan , Ren Xiangrui , Liu Hongkai , Zhang Xiaowei , Wang Meng , Hu Haifang 
Published: May 2023

Abstract
In order to develop the application of walnut kernel, the effect of steaming and roasting treatment on the amino acid composition, digestibility, conformation, physicochemical rheology and functional properties of walnut kernel at 95 ºC for different time (15, 20 and 30 min) was investigated, and compared to those of untreated sample. Scanning electron microscopy suggested that heating treatment had a notable effect on the microstructure of walnut kernel, especially the steam heating. Both treatments significantly increased the enthalpy, vitro protein digestibility, viscosity, G′ and G″ (p < 0.05), the order from high to low was steaming > roasting > untreated. All samples contained the amounts of essential amino acids, the amino acid score (AAS) of samples by steaming was the highest compared to that of the untreated and roasting, and the only limiting amino acid of walnut kernel before or after heat treatment was lysine. In addition, the protein of walnut kernel after heating treatment with the extension of time contained more α-helix and random coil structures compared to the untreated sample, while β-sheet and β-turns structures decreased. Moreover, the thermal treatment could cause the changes of the water/oil holding capacity, foaming and emulsifying properties of walnut kernel flour. When there were differences between the results of steaming and roasting samples, it was concluded that the water played an important role in steaming. These results suggested that the thermal treatment as an effective approach could improve the physico-chemical, structural and functional properties of walnut kernel and be potentially applied in the food processing.
Factors associated with adverse pregnancy outcomes of maternal syphilis in Henan, China, 2016-2022
Authors: Zhang Meng , Qu Huimin , Xu Feng , Xia Junfen , Hui Xiaoqing , Zhang Hongyan , Shi Cannan , He Junjian , Cao Yuan , Hu Mengcai 
Published: May 2023

Abstract
Background: Maternal syphilis not only seriously affects the quality of life of pregnant women themselves, but also may cause various adverse pregnancy outcomes (APOs). This study aimed to analysis the association between the related factors of maternal syphilis and APOs.
Methods: Pregnant women infected with syphilis in Henan Province from January 2016 to December 2022 were selected as the study participants. Data collection was conducted through the Preventing Mother-to-child Transmission of HIV, Syphilis and Hepatitis B Management Information System. Information on their demographic characteristics, treatment status, and pregnancy outcomes were collected. Multivariate Logistic regression models were used to analyze the factors associated with adverse outcomes among the study participants.
Results: The average age of the 7030 study participants included was 28.55 years old, and the incidence of APOs was 12.20%. For pregnant women infected with syphilis, the multivariate logistic regression results showed that the syphilis infected history (OR=1.378, 95% CI, 1.185-1.601) and the occurrence of abnormality during pregnancy (OR=4.993, 95% CI, 4.154-5.859) were risk factors. For the syphilis positive pregnant women receiving treatment, we found the syphilis infected history (OR=1.378, 95% CI, 1.185-1.601), the occurrence of abnormality during pregnancy (OR=4.993, 95% CI, 4.154-5.859), and not receiving standard treatment (OR=1.343, 95% CI, 1.133-1.592) to be risk factors.
Conclusions: Standard syphilis treatment is of great significance in reducing the incidence of APOs for pregnant women infected with syphilis.