bluuebunny/crossref_metadata_2025_split huggingface dataset:
Packaged drinking water in Indonesia: The determinants of household in the selection and management process
Authors: Puspita Tities , Dharmayanti Ika , Tjandrarini Dwi Hapsari , Zahra Zahra , Anwar Athena , Irianto Joko , Rachmat Basuki , Yunianto Andre 
Published: June 2023

Abstract

The availability of safe drinking water remains a challenge in Indonesia. Packaged water in bottles or refillable containers has been increasingly popular as an alternative to good-quality drinking water. This study aimed to identify the reasons for the selection, management, and factors that influenced bottled and refilled water use in Indonesia. A cross-sectional Household Drinking Water Quality (HDWQ) study was conducted in 34 Indonesian provinces in 2020 involving 7,236 households as analyzed samples. The data analysis also included the 2020 National Socioeconomic Survey data to obtain households' socioeconomic status. As many as 68 and 63% of households consumed good-quality bottled and refilled water, respectively. Health was the reason for 29% of households choosing good-quality bottled water, while 49% of households selected good-quality refilled water out of habit. Several factors related to the consumption of fine-quality packaged water were high social status, water physical quality, ease of access, health reason, monthly expenses to buy drinking water, and storing water in manufactured containers. Packaged water, whether bottled or refilled, does not guarantee good physical and chemical quality. Therefore, to ensure good quality, the water storage should be kept from contamination.
Identification and evolution characteristics of drought field in the Pearl River Basin based on REOF-ESMD
Authors: Ling Minhua , Hu Xiaoyue , Guo Xiaomin , Yu Lili 
Published: June 2023

Abstract

The traditional drought field studies are inadequate to study drought field characteristics from the perspective of trend and periodicity at the same time, especially to compare the interannual and interdecadal variations of different drought types in the drought field to reveal their similarity and difference patterns. The drought field in Pearl River Basin (PRB) was determined in this paper using the standardized precipitation evapotranspiration index (SPEI) and the empirical orthogonal function (EOF)/rotated empirical orthogonal function (REOF). Periodic characteristics and trend features of the drought field were recognized by extreme-point symmetric mode decomposition (ESMD) and other methods. The results showed that from the perspective of regional characteristics five different spatial modes may be used to categorize the interannual drought field of the PRB; there were interannual cycles associated with the southwest-type drought and the northwest-type drought. The central-south-, north-central- and eastern-type droughts had both interannual and interdecadal cycles; during the study period, the PRB's five types of drought revealed a changing tendency as opposed to a straightforward linear trend; from the interannual variation, the southwest-type drought was consistent with the northwest-type drought prior to 2000, and the north-central-type drought was consistent with the eastern-type drought before 2010.
Study on the method and model of water balance allocation of the Yellow River with overall fairness and efficiency
Authors: Wang Yu , Peng Shaoming , Wu Jian , Wan Fang , Zheng Xiaokang , Zhou Xiangnan , Shang Wenxiu , Zhang Fei 
Published: June 2023

Abstract
Under the changing environment, the problems of the water cycle and water resources in the basin become extremely complex, and the coordination of water use efficiency and fairness is extremely difficult. This paper takes the Yellow River Basin as the key research area and creates a balanced allocation method and model of water resources that take into account the fairness and efficiency of water use. The dynamic equilibrium allocation of water resources increment brought by new water source projects and regulation projects is realized, and the fine-tuning optimization of the water distribution scheme is realized. The results show that the optimal adjustment strategy of the water diversion scheme is to increase the upstream water allocation, and the adjustment range is 2.13%. The water allocation in the middle reaches was slightly increased by 0.25% to reduce the downstream and Hebei Province, Tianjin water allocation, and the adjustment range is −3.81%. The optimization scheme reflects the principle of ecological priority, guarantees the basic ecological environment water use in the Yellow River, balances the fairness and efficiency of economic and social water use outside the river, and provides technical support for water resources security in water-shortage basins.
Research on the allocation of water resources engineering projects based on multi-objective optimization
Authors: Lu Yongqin , Gan Lu , Chen Yonghua , Zheng Ningyao 
Published: June 2023

Abstract
The shortage of water resources (WR) directly affects the economic development and ecological environment in the region, and optimizing the allocation of water resources engineering (WRE) projects is the most valid method to solve this problem. Traditional WR allocation methods can no longer solve the complex configuration problems of complex WRE projects, and the emergence of artificial intelligence (AI) technology has not provided new technologies and methods for optimizing WR allocation. This article conducted research on multi-objective optimization configuration of WRE based on AI technology. First, it introduced the current situation and future development direction of WR allocation, indicating the transformation of WR allocation from single-objective optimization to multi-objective optimization, and the importance of WR allocation, which should be coordinated from multiple aspects such as economy, society, and ecology. Experiments were conducted on its multi-objective genetic algorithm from three aspects: water use assurance rate, economic and ecological benefits, and execution efficiency.
Detection of Circulating Cell-free DNA to Diagnose Hepatocellular
Carcinoma in Chinese Population: A Systematic Review and
Meta-analysis
Authors: Aalami Amir Hossein , Aalami Farnoosh , Aliabadi Ehsan Kargar , Amirabadi Amir , Sahebkar Amirhossein 
Published: June 2023

Background:
Cell-free circulating DNA has been known for many years, but this
knowledge has not been beneficial for diagnosis. In this meta-analysis, we examine the diagnostic
role of circulating cell-free DNA in HCC patients to find a reliable biomarker for the
early detection of HCC.

Materials and Methods:
We performed a systematic literature search using Science Direct,
Web of Science, PubMed/Medline, Scopus, Google Scholar, and Embase, up to April 1st,
2022. Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.3.3 software calculated the
pooled specificity, sensitivity, area under the curve (AUC), diagnostic odds ratio (DOR), positive
likelihood ratio (PLR), negative likelihood ratio (NLR) Q*index, and summary receiver--
operating characteristic (SROC) for the role of cfDNA as a biomarker for HCC patients.
Moreover, the subgroup analyses have been performed based on sample types (serum/plasma)
and detection methods (MS-PCR/methylation).

Results:
A total of 7 articles (9 studies) included 697 participants (485 cases and 212 controls).
The overall pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood
ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were 0.706
(95% CI: 0.671 - 0.739), 0.905 (95% CI: 0.865 - 0.937), 6.66 (95% CI: 4.36 - 10.18), 0.287
(95% CI: 0.185 - 0.445), 28.40 (95% CI: 13.01 - 62.0), and 0.93, respectively. We conducted
a subgroup analysis of diagnostic value, which showed that the plasma sample had a better diagnostic
value compared to the serum.

Conclusion:
This meta-analysis showed that cfDNA could be a fair biomarker for diagnosing
HCC patients.
Clinical Efficacy of the Huo Xue Hua Yu Method Combined with Aspirin in the
Treatment of Acute Cerebral Infarction: A Systematic Evaluation and Meta-analysis
Authors: Chen Chu , Ma Fang , Wen Xinli , Liu Xing , Tang Qing , Wu Yilun 
Published: June 2023

Objective:
The study aimed to evaluate the clinical efficacy of the Huo Xue Hua Yu method combined
with aspirin in the treatment of patients with acute cerebral infarction (ACI).

Methods:
By searching electronic databases, such as the Chinese Biomedical Literature Database (CBM), the
China National Knowledge Infrastructure Database (CNKI), the China Science and Technology Journal Database,
Wanfang, PubMed, Embase, and the Cochrane Library, all randomized controlled trials (RCTs) published
before 14 July, 2022, and published in Chinese or English languages were selected. Statistical analysis was performed
using Review Manager 5.4 calculation software to calculate the odds ratio (OR), mean difference (MD),
95% confidence interval (CI), and p values.

Results:
13 articles that included 1,243 patients were identified; in 646 of them, the Huo Xue Hua Yu method
combined with aspirin has been administered, while 597 have only been administered aspirin therapy. The
combined treatment significantly improved clinical efficacy (OR: 4.41, 95% CI: 2.90 to 5.84, p < 0.001, I2 = 0),
as assessed by the National Institutes of Health Stroke Scale score (MD = -4.18, 95% CI: -5.69 to -2.67, p <
0.001, I2 = 94%), Barthel score (MD = -2.23, 95% CI: -2.66 to -1.81, p < 0.001, I2 = 82%), the China Stroke
Scale score (MD = 6.74, 95% CI: -3.49 to 16.96, P = 0.20, I2 = 99%), packed cell volume (MD = -8.45, 95%
CI: -8.81 to -8.09, p < 0.001, I2 = 98%), fibrinogen levels (MD = -0.93, 95% CI: -1.23 to -0.63, p < 0.001, I2 =
78%) and plasma viscosity (MD = -0.51, 95% CI: -0.72 to -0.30, p < 0.001, I2 = 62%).

Conclusion:
The combination of the Huo Xue Hua Yu method and aspirin represents a beneficial adjunctive
therapy for ACI.
Peganum harmala L.: A Review of Botany, Traditional Use, Phytochemistry, Pharmacology, Quality Marker, and Toxicity
Authors: Li Ling-Na 
Published: June 2023

Background:Peganum harmala L. is a perennial herb of Peganum in Zygophyllaceae family. It has been used as a national medicinal herb with the efficacy of strengthening muscle, warming stomach, dispelling cold, and removing dampness in Chinese folk. Clinically, it is mainly used to treat diseases such as weak muscles and veins, joint pain, cough and phlegm, dizziness, headache, and irregular menstruation.Methods:The relevant information about P. harmala L. in this review is based on online databases, including Elsevier, Willy, Web of Science, PubMed, ScienceDirect, SciFinder, SpringLink, Google Scholar, Baidu Scholar, ACS publications, SciHub, Scopus, and CNKI. The other information was acquired from ancient books and classical works about P. harmala L.Results:P. harmala L. is an important medicinal plant with a variety of traditional uses according to the theory of Chinese medicine. Phytochemical research revealed that P. harmala L. contained alkaloids, volatile oils, flavonoids, triterpenoids, coumarins, lignins, anthraquinones. Modern studies showed P. harmala L. possessed multiple bioactivities, including anti-cancer, neuroprotective, anti-bacterial, anti-inflammatory, hypoglycemic, anti-hypertensive, anti-asthmatic, and insecticidal activities. Furthermore, the contents of the quality marker and toxicity of P. harmala L. were summarized and analyzed in this review.Conclusion:The botany, traditional use, phytochemistry, pharmacology, quality marker, and toxicity of P. harmala L. were reviewed in this paper. It will not only provide an important clue for further studying P. harmala L., but also supply an important theoretical basis and valuable reference for in-depth research and exploitations of this plant in the future.
Oncogenic Alterations of Metabolism Associated with Resistance
to Chemotherapy
Authors: Ghasemi Fahimeh , Farkhondeh Tahereh , Samarghandian Saeed , Ghasempour Alireza , Shakibaie Mehdi 
Published: June 2023

Abstract:
Metabolic reprogramming in cancer cells is a strategy to meet high
proliferation rates, invasion, and metastasis. Also, several researchers indicated that the
cellular metabolism changed during the resistance to chemotherapy. Since glycolytic
enzymes play a prominent role in these alterations, the ability to reduce resistance to
chemotherapy drugs is promising for cancer patients. Oscillating gene expression of
these enzymes was involved in the proliferation, invasion, and metastasis of cancer
cells. This review discussed the roles of some glycolytic enzymes associated with
cancer progression and resistance to chemotherapy in the various cancer types.
Role of Brain Endothelin Receptor Type B (ETB) in the Regulation of
Tyrosine Hydroxylase in the Olfactory Bulb of DOCA-Salt Hypertensive
Rats
Authors: Cassinotti Luis , Guil María , Bianciotti Liliana , Vatta Marcelo 
Published: June 2023

Background:
We previously reported that endothelins (ETs) regulate tyrosine hydroxylase
(TH) activity and expression in the olfactory bulb (OB) of normotensive and hypertensive animals.
Applying an ET receptor type A (ETA) antagonist to the brain suggested that endogenous ETs bind to
ET receptor type B (ETB) to elicit effects.

Objective:
The aim of the present work was to evaluate the role of central ETB stimulation on the regulation
of blood pressure (BP) and the catecholaminergic system in the OB of deoxycorticosterone acetate
(DOCA)-salt hypertensive rats.

Methods:
DOCA-salt hypertensive rats were infused for 7 days with cerebrospinal fluid or IRL-1620
(ETB receptor agonist) through a cannula placed in the lateral brain ventricle. Systolic BP (SBP) and
heart rate were recorded by plethysmography. The expression of TH and its phosphorylated forms in the
OB were determined by immunoblotting, TH activity by a radioenzymatic assay, and TH mRNA by
quantitative real-time polymerase chain reaction.

Results:
Chronic administration of IRL-1620 decreased SBP in hypertensive rats but not in
normotensive animals. Furthermore, the blockade of ETB receptors also decreased TH-mRNA in
DOCA-salt rats, but it did not modify TH activity or protein expression.

Conclusion:
These findings suggest that brain ETs through the activation of ETB receptors contribute to
SBP regulation in DOCA-salt hypertension. However, the catecholaminergic system in the OB does not
appear to be conclusively involved although mRNA TH was reduced. Present and previous findings
suggest that in this salt-sensitive animal model of hypertension, the OB contributes to chronic BP
elevation.
Predicting the Adsorption Behavior of 6-mercaptopurine Anticancer Drug
upon Polyoxazoline Nanocarrier: A Theoretical Study
Authors: Rahmanifar Leila , Azarakhshi Fatemeh , Moniri Elham 
Published: June 2023

Abstract:
Predicting the adsorption behavior of the 6-Mercaptopurine (MCP) anticancer drug upon
the polyoxazolinenano-carrier was investigated using DFT and TD-DFT methods by B3LYP/6-31G*
level in the gas phase and water solution. Based on the thermochemical parameters, the MCP/polymer
complex in the solvent water is more stable rather than the gas phase. The adsorption energies of the
MCP/polymer complex displayed that the adsorption process is exothermic. The UV/Vis absorption
and IR spectra analysis were calculated to investigate the changes happening in the interaction of the
MCP with the polymer. FMO analysis indicated that the energy gap (Eg) of the polymer decreased after
the adsorption process. Electronic properties and MEP analysis were also studied. Based on NBO
analysis and charge difference (ΔN), the charge transfer in MCP/polymer occurs essentially from the
polymer to the MCP drug, which is consistent with the results of NBO analysis. It is predicted that the
POZ polymer can be used as a drug delivery system for MCP drug.
Nanotechnology-Based Approaches for Nose-to-Brain Drug Delivery in Neurodegenerative Diseases
Authors: Shukla Sugat , Tiwari Srishti , Bhattacharya Ragghee , Ojha Smriti , Mishra Sudhanshu , Gupta Saurabh Kumar 
Published: June 2023

:
Drug delivery to the brain is a challenging task as many drugs do not cross the blood-brain
barrier (BBB). As a result, designing strategies to target drugs to the brain requires significant effort.
However, recent research has focused on the administration of drugs through the nose to the brain, a noninvasive
way to bypass the BBB and deliver therapeutic molecules directly to the brain. Nose-to-brain
drug delivery is a promising approach that allows for the direct transportation of therapeutic molecules to
the brain while increasing drug concentration in the brain. This approach has gained considerable attention
due to its non-invasive nature, which makes it feasible, reliable, and efficient. One promising approach
for nose-to-brain drug delivery is the use of nanoparticles as a platform for drug and gene delivery.
Nanoparticles offer several advantages, including the ability to protect therapeutic drugs from degradation
and increase the efficacy of drug delivery due to their unique size, shape, and surface features. Nanoparticles
can also be engineered to target specific cells or tissues, enabling more precise drug delivery to the
brain. The use of nanoparticles for nose-to-brain drug delivery has been extensively studied, and recent
developments have shown promising results. In addition, patents relating to medication targeting via the
nasal route have been developed. These patents cover various aspects of drug delivery, including the use
of different types of nanoparticles, methods for producing nanoparticles, and methods for delivering nanoparticles
to the brain.
Synthesis and Evaluation of Novel Substituted N-Aryl 1,4-Dihydropyridines as Antituberculostatic Agents
Authors: Seitz Lisa , Reiling Norbert , Vorreiter Christopher , Sippl Wolfgang , Kessler Sonja , Hilgeroth Andreas 
Published: June 2023

Background:
Tuberculosis has been the main cause of mortality of infectious diseases
worldwide, with strongly limited therapeutic options. With increasing resistance and missing suitable
drugs in those cases, there is a strong need for novel antituberculostatic drugs. We developed novel
N-aryl 1,4-dihydropyridines with various substitution patterns to evaluate them as antituberculostatic
agents.

Methods:
1,4-Dihydropyridine derivatives were synthesized and purified by column chromatography
or recrystallization. The mycobacterial growth inhibition was determined in a fluorescent mycobacterial
growth assay.

Results:
The compounds were prepared in a simple one-pot reaction under acidic conditions with
structurally varied components. The substituent effects on the determined mycobacterial growth inhibitory
properties are discussed.

Conclusion:
Lipophilic diester substituted derivatives show promising activities that were additionally
affected by the aromatic substituent functions. Thus, we identified compounds with activities almost
reaching that of the used antimycobacterial drug as control.
Entropy Measures with Three-axis Motion Time-series Data: Comparison of Dominant and Non-dominant Hand in Multi-directional Reach
Authors: Praditpod Nuttaporn , Tantipoon Phongpan , Zhang Xinyu , Rauchhaus Petra , Li Chunhui , Huang Zhihong 
Published: June 2023

Background:Motion variance differs among individuals, knowing as the differences in dominant and non-dominant hand functions provide beneficial information to clinicians or therapists regarding accurate diagnosis and rehabilitation purposes. However, due to subjective considerations, there are some limitations of the handedness questionnaires, which are one of the standard methods for evaluating interlimb function differences.Objective:This study aims to quantify the differences in upper limb motions between the dominant and non-dominant hands in the reaching task using approximate entropy (ApEn) and sample entropy (SampEn) measures. This study also provides proper combinations of parameter valuesmandrfor the ApEn and SampEn measures in the hand movement data of the reaching task.Methods:Twenty volunteers performed a multi-directional reaching task. The acceleration data of hand motions were recorded by GENEActiv 3D acceleration sensor (Activinsights Ltd., UK) with a sampling frequency of 1000 Hz. In addition, the ApEn and SampEn values were analysed.Results:The ApEn values of the dominant hand were statistically significantly lower than those of the non-dominant hand for parameter combinations ofm=2,3,4,5 withr=0.15,0.20,0.25 for the Y- and Z-axis (p<0.05). The SampEn values of the dominant hand significantly demonstrated lower than those of the non-dominant hand for all axes when computing on combinations of parameterm=2,3,4,5 withr=0.15,0.20 (p<0.05).Conclusion:The ApEn and SampEn measures could be used to predict the degree of regularity or complexity of the reaching hand motion time-series data. These entropy measures also reveal the differences between the dominant and non-dominant hand movements, quantifying movement differences in the dynamic motor tasks associated with hemispheric brain asymmetry.
Strengthening Communication: A Strategy to Increase Community Satisfaction in Stunting Services in Indonesia
Authors: Sazali Hasan , Utami Tri Niswati , Batubara Chuzaimah , Azizah Noor , Susilawati Susilawati , Padli Nasution Muhammad Irwan , Albani Nasution Muhammad Syukri , Sari Seva Maya , Harahap Rafnitul Hasanah 
Published: June 2023

Introduction:The Indonesian government has prioritized stunting management programs, but until 2022 the prevalence of stunting is still high.Objectives:The purpose of this research is to develop a strategy to increase community satisfaction with stunting services oriented toward strengthening communication.Methods:This is a cross-sectional design research with data collected from a sample population of 298 mothers who have stunted children through a survey and analyzed using path analysis with SEM-PLS.Results:The result showed that communication affects stunting service facilities and sanitation management with a P-value of 0.000, respectively. Communication does not directly affect stunting service satisfaction, it is moderated by the variables of facilities and sanitation, which play a role in strengthening or weakening the effect of stunting service satisfaction. An essential factor that can be used to produce optimal stunting service satisfaction is strengthening communication.Conclusion:Strengthening communication between regional institutions at the Regency level synergistically supports the provision of the required facilities, thereby increasing community satisfaction. Furthermore, strengthening cross-sectoral communication synergistically in managing environmental sanitation supports stunting service programs. This research contributes to the government's emphasis on stunting service policies to strengthen communication between service providers and cross-sectoral communication.