bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive risk modelling of high resource users under different prescription drug coverage policies in Ontario and Manitoba, Canada
Authors: Kornas Kathy , Sarkar Joykrishna , Fransoo Randall , Rosella Laura C. 
Published: July 2023

Abstract
Introduction
Studying high resource users (HRUs) across jurisdictions is a challenge due to variation in data availability and health services coverage. In Canada, coverage for pharmaceuticals varies across provinces under a mix of public and private plans, which has implications for ascertaining HRUs. We examined sociodemographic and behavioural predictors of HRUs in the presence of different prescription drug coverages in the provinces of Manitoba and Ontario.

Methods
Linked Canadian Community Health Surveys were used to create two cohorts of respondents from Ontario (n = 58,617, cycles 2005–2008) and Manitoba (n = 10,504, cycles 2007–2010). HRUs (top 5%) were identified by calculating health care utilization 5 years following interview date and computing all costs in the linked administrative databases, with three approaches used to include drug costs: (1) costs paid for by the provincial payer under age-based coverage; (2) costs paid for by the provincial payer under income-based coverage; (3) total costs regardless of the payer (publicly insured, privately insured, and out-of-pocket). Logistic regression estimated the association between sociodemographic, health, and behavioral predictors on HRU risk.

Results
The strength of the association between age (≥ 80 vs. <30) and becoming an HRU were attenuated with the inclusion of broader drug data (age based: OR 37.29, CI: 30.08–46.24; income based: OR 27.34, CI: 18.53–40.33; all drug payees: OR 29.08, CI: 19.64–43.08). With broader drug coverage, the association between heavy smokers vs. non-smokers on odds of becoming an HRU strengthened (age based: OR 1.58, CI: 1.32–1.90; income based: OR 2.97, CI: 2.18–4.05; all drug payees: OR 3.12, CI: 2.29–4.25). Across the different drug coverage policies, there was persistence in higher odds of becoming an HRU in low income households vs. high income households and in those with a reported chronic condition vs. no chronic conditions.

Conclusions
The study illustrates that jurisdictional differences in how HRUs are ascertained based on drug coverage policies can influence the relative importance of some behavioural risk factors on HRU status, but most observed associations with health and sociodemographic risk factors were persistent, demonstrating that predictive risk modelling of HRUs can occur effectively across jurisdictions, even with some differences in public drug coverage policies.
Large-scale real-life analysis of survival and usage of therapies in multiple myeloma
Authors: Lopez-Muñoz N. , Hernández-Ibarburu G. , Alonso R. , Sanchez-Pina J. M. , Ayala R. , Calbacho M. , Cuellar C. , Cedena M. T. , Jiménez-Ubieto A. , Iñiguez R. , Pedrera M. , Cruz J. , Meloni L. , Pérez-Rey D. , Serrano P. , de la Cruz J. , Martinez-Lopez J. 
Published: July 2023

AbstractSurvival in multiple myeloma has improved significantly in recent years, especially in young patients. We reviewed the evolution of the survival of patients with MM in three groups based on age at MM diagnosis over three time periods between 1999 and 2020 at our 12 de Octubre Hospital institution (H12O). Then, to confirm our results, we used data from TriNetx, a global health research platform that includes patients from Europe to US. Finally, we analysed differences in the patterns of treatment between networks across the world. Kaplan‒Meier analysis was used to estimate survival probabilities, and between-group differences were tested using the log-rank test and hazard ratio. For patients from H12O, the median OS was 35.61, 55.59 and 68.67 months for the 1999–2009, 2010–2014 and 2015–2020 cohorts, respectively (p = 0.0001). Among all patients included in the EMEA network, the median OS was 20.32 months versus 34.75 months from 1999–2009 versus 2010–2014. The median OS from the 2010–2014 versus 2015–2020 time cohorts was 34.75 months versus 54.43 months, respectively. In relation to the US cohort, the median OS from before 2010 versus 2010–2014 was not reached in either time cohort and neither when comparing the 2010–2014 versus 2015–2019 time cohorts. Bortezomib is the most commonly used drug in the EMEA cohort, while lenalidomide is the most commonly used drug in the US cohort. This large-scale study based on real-world data confirms the previous finding that MM patients have increased their survival in the last two decades.
Learning Symbolic Expressions: Mixed-Integer Formulations, Cuts, and Heuristics
Authors: Kim Jongeun , Leyffer Sven , Balaprakash Prasanna 
Published: July 2023

In this paper, we consider the problem of learning a regression function without assuming its functional form. This problem is referred to as symbolic regression. An expression tree is typically used to represent a solution function, which is determined by assigning operators and operands to the nodes. Cozad and Sahinidis propose a nonconvex mixed-integer nonlinear program (MINLP), in which binary variables are used to assign operators and nonlinear expressions are used to propagate data values through nonlinear operators, such as square, square root, and exponential. We extend this formulation by adding new cuts that improve the solution of this challenging MINLP. We also propose a heuristic that iteratively builds an expression tree by solving a restricted MINLP. We perform computational experiments and compare our approach with a mixed-integer program–based method and a neural network–based method from the literature. History: Accepted by Pascal Van Hentenryck, Area Editor for Computational Modeling: Methods & Analysis. Funding: This work was supported by the Applied Mathematics activity within the U.S. Department of Energy, Office of Science, Advanced Scientific Computing Research [Grant DE-AC02-06CH11357]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0050 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0050 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Construction of the CRISPR/Cas9 module and genetic transformation of aromatic rice cv. Mentik Wangi for developing bacterial leaf blight resistance
Authors: RIFHANI NURUL FARIDAH , APRIANA ANIVERSARI , SISHARMINI ATMITRI , SANTOSO TRI JOKO , TRIJATMIKO KURNIAWAN RUDI , SLAMET-LOEDIN INEZ H. , YUNUS AHMAD 
Published: July 2023

Abstract. Rifhani NF, Apriana A, Sisharmini A, Santoso TJ, Trijatmiko KR, Slamet-Loedin IH, Yunus A. 2023. Construction of the CRISPR/Cas9 module and genetic transformation of aromatic rice cv. Mentik Wangi for developing bacterial leaf blight resistance. Biodiversitas 24: 3258-3268.Rice cv. Mentik Wangi is a local aromatic rice that is susceptible to pests and diseases, such as bacterial leaf blight (BLB) caused by Xanthomonas oryzae(Xoo). This bacteria can cause damage to plants thereby reducing crop yields. This study aimed to obtain the CRISPR/Cas9 module construct as well as introducing the construct into rice cv. Mentik Wangi for developing BLB resistance. The manufacture of the CRISPR/Cas9 module was carried out using the Golden Gate method, and the introduction of that construct into rice cv. Mentik Wangi was carried out using Agrobacterium tumefaciens. Constructing a CRISPR/Cas9 module with multiple gRNA of OsSWEET11 and OsSWEET14 genes has succeeded, 129 putative transformant lines of T0 generation produced with the regeneration and transformation efficiency values ??are respectively 9.4% and 9.8%. The results showed that 36 lines were positive for the hpt gene, indicating that the CRISPR/Cas9-gRNAOsSWEET module construct was successfully entered into rice cv. Mentik Wangi. Further analysis is needed to identify mutagenesis in the target gene region of TI generation transgenic plants as well as phenotypic tests for BLB resistance.
Impact of cross border reverse migration in Delhi–UP region of India during COVID-19 lockdown
Authors: Dwivedi Shubhangi , Perumal Saravana Keerthana , Kumar Sumit , Bhattacharyya Samit , Kumari Nitu 
Published: July 2023

Abstract
The declaration of a nationwide lockdown in India led to millions of migrant workers, particularly from Uttar Pradesh (UP) and Bihar, returning to their home states without proper transportation and social distancing from cities such as Delhi, Mumbai, and Hyderabad. This unforeseen migration and social mixing accelerated the transmission of diseases across the country. To analyze the impact of reverse migration on disease progression, we have developed a disease transmission model for the neighboring Indian states of Delhi and UP. The model’s essential mathematical properties, including positivity, boundedness, equilibrium points (EPs), and their linear stability, as well as computation of the basic reproduction number

(

R

0

)

\left({R}_{0})

, are studied. The mathematical analysis reveals that the model with active reverse migration cannot reach a disease-free equilibrium, indicating that the failure of restrictive mobility intervention caused by reverse migration kept the disease propagation alive. Further, PRCC analysis highlights the need for effective home isolation, better disease detection techniques, and medical interventions to curb the spread. The study estimates a significantly shorter doubling time for exponential growth of the disease in both regions. In addition, the occurrence of synchronous patterns between epidemic trajectories of the Delhi and UP regions accentuates the severe implications of migrant plight on UP’s already fragile rural health infrastructure. By using COVID-19 incidence data, we quantify key epidemiological parameters, and our scenario analyses demonstrate how different lockdown plans might have impacted disease prevalence. Based on our observations, the transmission rate has the most significant impact on COVID-19 cases. This case study exemplifies the importance of carefully considering these issues before implementing lockdowns and social isolation throughout the country to combat future outbreaks.
Indentation creep behavior of Fe–8Ni–xZr oxide dispersion strengthened alloys
Authors: Tekin Mustafa , Muhaffel Faiz , Kotan Hasan , Baydoğan Murat 
Published: July 2023

Abstract
This study was conducted to understand the creep behavior of two oxide dispersion strengthened alloys containing Zr as the alloying addition by performing indentation creep tests at room temperature. The oxide dispersion strengthened alloys were Fe–8Ni–xZr (x = 1 and 4 at.%, i.e., Zr-1 and Zr-4 alloys, respectively), which had been previously fabricated by mechanical alloying; followed by consolidation via equal channel angular extrusion at 1000 °C. The indentation tests were conducted under a maximum load of 100 mN with the loading rates at 300 and 400 mN min−1. The hardness was calculated by the Oliver–Pharr method, and the creep properties, such as the creep displacement, creep strain rate, creep stress, and stress exponent n, were determined. The results showed that the Zr-4 alloy was harder than the Zr-1 alloy. However, the creep resistance of the Zr-1 alloy was better than that of the Zr-4 alloy. It was further demonstrated that both the hardness and creep resistance depended on the loading rate. Moreover, a possible creep mechanism was proposed. Although the tests were performed at room temperature, they can provide insight into the effect of an oxide dispersion strengthened alloys microstructure on creep at higher temperatures.
Editorial: El Caribe e Hispanoamérica: la literatura en los bordes
Authors: Caballero De la Hoz Amilkar 
Published: July 2023

El número 32 de Cuadernos de Literatura del Caribe e Hispanoamérica incluye trabajos que analizan manifestaciones estéticas que se ubican en la liminalidad.Se trata de textos que se sitúan en un in-between espacial, temporal y temático, y que antes que afirmar e instituir verdades o nociones, expresan la vaguedad y la indeterminación.
La visión del inocente
Authors: Chico Quintana Rafael Arturo 
Published: July 2023

«Inmolar un animal / Y en silencio, en un terrible rezo de tu carne / devorar lentamente su ímpetu, su ansia / Saberte impuro entonces y gemir / en un terrible rezo de tu alma / Ahora, una vez más / nunca podrás perdonarte», sentencia el sujeto lírico del poema Ritual (Bustos, 2016, p. 196), y los versos bien parecieran un anuncio de Muerte de Dios y poesía moderna en Colombia, y es que esta última obra de Rómulo Bustos hace eco de estos versos al reflexionar sobre las consecuencias de una herida, ahora connatural a la cultura occidental y sobre todo moderna. La muerte de Dios, que fuera profesada como una nueva victoriosa o reclamo por la libertad de ser humano por-y-para-sí-mismo, en realidad tomó la forma de una problemática digerida con dificultad, una veces con renuencia, otras con negación, otras con aceptación acompañada de fervor disoluto, otras con ateísmo cientificista, pero secretamente místico, levantando cultos de capilla a ciertos predicadores de alguna versión del evangelio de la Razón. Es así que, con una mirada menos pasiva que la de un testigo, pero más inocente que la de un hurgador de verdades cuya voz ha sido empeñada a las obligaciones de grupos o instituciones, Bustos hace arqueología del problema en su primer capítulo, titulado muy ilustrativamente Los avatares del Dios de la modernidad. Allí, la historia de esta problemática de larga data es reescrita entre los intersticios del discurso oficializado, y no hablo de deconstrucción, sino de una racionalidad sincera que rastrea orígenes, pero también indaga en sus proyecciones: desde Jean Paul Richter a Nietzsche, desde el romanticismo hasta su legado para la modernidad, desde el libertino hasta el poeta maldito… desde el Discurso del Cristo muerto, el cual, desde lo alto del edificio del mundo, proclama que Dios no existe (J. P. Richter) hasta sus resonancias futuras, y es gracias a ello que la voz decidida de un Bustos, sin el menor asomo de temor frente los azarosos rostros de una defunción de lutos prolongados, nos lleva comprender una de las causas profundas del constante desencanto, pesimismo, melancolía y dilatada y reincidente rebeldía de mucha de la poesía moderna hasta nuestros días, habitada de sujetos líricos cuya voz sólo sabe enunciar con disonancia, incertidumbre y enigmatismo. Con esa forma de decir que el trabajo clásico de Hugo Friedrich supo describir, pero que ahora Rómulo Bustos nos explica, estudiando el limo desde el que crece y se alimenta.
Bajo el brillo de la luna: de edvard munch a la poesía de Nelson Romero Guzmán
Authors: Gaitán Bayona Jorge Ladino 
Published: July 2023

El objetivo de este artículo es analizar la intertextualidad entre poesía y pintura en el libro Bajo el brillo de la luna, a partir del concepto de ecfrasis. Se toman planteamientos teóricos y metodológicos de William Mitchell, Michael Rifaterre, Pedro Agudelo y Luz Pimentel. La hipótesis es que el poeta recrea pinturas de Edvard Munch para explorar el proceso de la creación artística. Se concluye que el libro aporta a la lírica colombiana basada en la pintura. Sus poemas reinventan a Munch y exaltan el arte como morada digna cuando el autor sufre locura, desencanto y miedo a la muerte.
Strategies for integrating a web-based learning environment based on authentic learning in distance learning for elementary school students
Authors: Hidayati Abna , Eldarni  , Solfema  , Handrianto Ciptro , Sunarti Vevi 
Published: July 2023

This research aimed to find a strategy to integrate web-based learning based on authentic learning by identifying the dominant factors regarding teachers' authentic activities. The research method was a teacher survey that used web-based learning. Questionnaires were given to 100 teachers regarding the use of authentic activities. The questionnaire was tested for validity and had a high load factor of more than 0.6. Authentic learning had an effect of 0.689. The data was processed by factorial analysis to obtain the dominant value. Furthermore, a strategy to integrate web-based learning was developed in learning. The results showed that the dominant authentic learning activities used were real-world activities, integrated assessment, various sources and final product design. It can be concluded that using web-based learning applications based on authentic learning provides real-life experiences for students and supports learning to be more meaningful.
Surgical Site Infection Is Not Associated with 1-Year Progression-Free Survival After Endoprosthetic Reconstruction for Lower-Extremity Osteosarcoma
Authors: Jackson Kristopher J. , Sullivan Camille D. , Zimel Melissa N. , Wustrack Rosanna L. ,   on behalf of the PARITY Investigators
Published: July 2023

Background:
Although there is evidence suggesting that postoperative infection confers a survival benefit in osteosarcoma treated with resection and endoprosthetic reconstruction, there have been no prospective studies to date to support these findings. This secondary analysis of Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) study data examines the relationship between surgical site infection (SSI) and disease progression within 12 months after limb salvage surgery.

Methods:
The PARITY trial was an international, multicenter, prospective randomized controlled trial of 604 patients who underwent resection of a lower-extremity bone tumor and endoprosthetic reconstruction. Our primary outcome was progression-free survival (PFS) at 1 year following surgery among the patients with osteosarcoma. Subgroup analyses by disease stage at presentation and infection severity were also performed. Cox proportional hazard models were employed to examine the association between clinical and tumor characteristics, SSI, and PFS. Kaplan-Meier analysis was used to determine the effect of SSI on PFS.

Results:
The 274 PARITY patients with osteosarcoma were included in this secondary analysis. Thirty-two (11.7%) of the patients presented with metastasis at baseline; 53 (19.3%) of the patients developed an SSI. There was no difference in 1-year PFS between patients with and without SSI. There was no decreased risk of disease progression at 1 year in patients with localized disease at baseline who developed an SSI (hazard ratio [HR] = 1.21; 95% confidence interval [CI] = 0.64 to 2.28). Infection was associated with increased disease progression at 1 year in patients with baseline metastases (HR = 4.26; 95% CI = 1.11 to 16.3).

Conclusions:
No positive association was detected between postoperative infection and PFS at 1 year following surgery in this secondary analysis of prospective data. However, this analysis suggests infection could be a risk factor for early disease progression in patients with baseline metastases, and future investigations may better elucidate the association between disease burden and the host immune response to advance immunotherapeutic strategies for osteosarcoma.

Level of Evidence:
Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
Open Versus Core Needle Biopsy in Lower-Extremity Sarcoma
Authors: Burke Zachary D.C. , Lazarides Alexander L. , Gundavda Manit K. , Griffin Anthony M. , Tsoi Kim M. , Ferguson Peter C. , Wunder Jay S. ,   on behalf of the PARITY Investigators
Published: July 2023

Background:
Historically, open biopsy (OB) was the gold standard for sarcoma diagnosis. Core needle biopsy (CNB) has become increasingly common. There are limited data evaluating how the type of biopsy impacts definitive surgical resection or postoperative outcomes. The aims of this study were to (1) characterize current international biopsy practice patterns, and (2) evaluate how the type of biopsy performed impacts the resection surgery, infection risk, oncological complications, and patient-reported functional outcome scores.

Methods:
This study was a preplanned secondary analysis of the prospective, multicenter PARITY (Prophylactic Antibiotic Regimens in Tumor Surgery) study. Patients with a benign diagnosis, metastatic disease, or no biopsy prior to surgery were excluded. Prospectively collected demographic, biopsy, surgical, and outcome variables were analyzed, and differences between patients undergoing OB and CNB were assessed. Parametric and nonparametric tests were used to compare variables between groups, and the Cox proportional hazards method was used to compare infection-related and oncological outcomes at 1 year. Median functional outcome scores at 1 year were compared.

Results:
Four hundred and sixty-four patients met the inclusion criteria. Data were collected from 48 sarcoma centers in 12 countries. CNB was the more utilized biopsy modality overall (57.5%). OB was more common in the U.S. and Canada. The median operative time was significantly longer for patients who underwent OB (324 versus 260 minutes; p < 0.001). Significantly more skin (p < 0.001) and fascial tissue (p < 0.001) were excised in the OB group, which also had a lower rate of primary closure (86.3% versus 92.9%; p = 0.03). There were no differences in surgical site infection or oncological outcomes between the groups at 1-year follow-up.

Conclusions:
CNB was the more common biopsy modality in the PARITY study in most countries. However, OB was more common in the U.S. and Canada. Patients undergoing OB had longer operative times, more excised tissue, and lower rates of primary closure, but this did not translate to differences in infection rates or oncological outcomes, including local recurrence.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Locating and ranking development plans of Iron and Steel Industries in Afghanistan by using FAHP and FTOPSIS methods
Authors: salehy Saleh Mohammad , Aimaq Mohammad Bashir , Shahabi Reza Shakoor 
Published: July 2023

Abstract
Due to the growth of steel industry in the world, the rich resources of ore, Abundance of inputs required by the iron and steel industry and higher demand for steel in Afghanistan, the idea of ​​designing and locating development plans in the field of iron and steel industry was created. To increase existing competitive advantages and gaining the most added value for Afghanistan requires suitable locations. In this paper, six cases as criteria and nineteen cases as sub-criteria that have a greater impact on the construction of iron and steel industries, selected after interviews with experts. The questionnaires have been arranged and distributed by google-forms and interviews have been conducted with experts. The weights of the criteria and sub-criteria were calculated based on the results of the questionnaires and using the FAHP. Then by using the FTOPSIS, the plans are ranked based on the similarity index. As a result, which the Bamyan has come in first position and Kandahar has come in recent position of development planning to invest. In the end, for more accuracy and correctness of the research after completing all preconditions, sensibility analysis among options according criteria and sub-criteria has been done in five scenarios.