bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conflicting findings on the effectiveness of hydrogen therapy for ameliorating vascular leakage in a 5-day post hypoxic-ischemic survival piglet model
Authors: Htun Yinmon , Nakamura Shinji , Nakao Yasuhiro , Mitsuie Tsutomu , Ohta Kenichi , Arioka Makoto , Yokota Takayuki , Inoue Eri , Inoue Kota , Tsuchiya Toi , Koyano Kosuke , Konishi Yukihiko , Miki Takanori , Ueno Masaki , Kusaka Takashi 
Published: June 2023

AbstractNeonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in newborns in both high- and low-income countries. The important determinants of its pathophysiology are neural cells and vascular components. In neonatal HIE, increased vascular permeability due to damage to the blood–brain barrier is associated with seizures and poor outcomes in both translational and clinical studies. In our previous studies, hydrogen gas (H2) improved the neurological outcome of HIE and ameliorated the cell death. In this study, we used albumin immunohistochemistry to assess if H2 inhalation effectively reduced the cerebral vascular leakage. Of 33 piglets subjected to a hypoxic-ischemic insult, 26 piglets were ultimately analyzed. After the insult, the piglets were grouped into normothermia (NT), H2 ventilation (H2), therapeutic hypothermia (TH), and H2 combined with TH (H2-TH) groups. The ratio of albumin stained to unstained areas was analyzed and found to be lower in the H2 group than in the other groups, although the difference was not statistically significant. In this study, H2 therapy did not significantly improve albumin leakage despite the histological images suggesting signs of improvement. Further investigations are warranted to study the efficacy of H2 gas for vascular leakage in neonatal HIE.
Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy
Authors: Metge Brandon J. , Alsheikh Heba A. , Chen Dongquan , Elhamamsy Amr R. , Hinshaw Dominique C. , Chen Bo-Ruei , Sleckman Barry P. , Samant Rajeev S. , Shevde Lalita A. 
Published: June 2023

AbstractHyperactivated ribosome biosynthesis is attributed to a need for elevated protein synthesis that accommodates cell growth and division, and is characterized by nucleomorphometric alterations and increased nucleolar counts. Ribosome biogenesis is challenged when DNA-damaging treatments such as radiotherapy are utilized. Tumor cells that survive radiotherapy form the basis of recurrence, tumor progression, and metastasis. In order to survive and become metabolically revitalized, tumor cells need to reactivate RNA Polymerase I (RNA Pol I) to synthesize ribosomal RNA, an integral component of ribosomes. In this study, we showed that following radiation therapy, tumor cells from breast cancer patients demonstrate activation of a ribosome biosynthesis signature concurrent with enrichment of a signature of Hedgehog (Hh) activity. We hypothesized that GLI1 activates RNA Pol I in response to irradiation and licenses the emergence of a radioresistant tumor population. Our work establishes a novel role for GLI1 in orchestrating RNA Pol I activity in irradiated breast cancer cells. Furthermore, we present evidence that in these irradiated tumor cells, Treacle ribosome biogenesis factor 1 (TCOF1), a nucleolar protein that is important in ribosome biogenesis, facilitates nucleolar translocation of GLI1. Inhibiting Hh activity and RNA Pol I activity disabled the outgrowth of breast cancer cells in the lungs. As such, ribosome biosynthesis and Hh activity present as actionable signaling mechanisms to enhance the effectiveness of radiotherapy.
Central Auditory Processing Dysfunction in Service Members and Veterans: Treatment Considerations and Strategies
Authors: Tepe Victoria , Guillory Lisa , Boudin-George Amy , Cantelmo Tasha , Murphy Sara 
Published: June 2023

Purpose:
Military risk factors such as blast exposure, noise exposure, head trauma, and neurotoxin exposure place Service members and Veterans at risk for deficits associated with auditory processing dysfunction. However, there is no clinical guidance specific to the treatment of auditory processing deficits in this unique population. We provide an overview of available treatments and their limited supporting evidence for use in adults, emphasizing the need for multidisciplinary case management and interdisciplinary research to support evidence-based solutions.

Method:
We explored relevant literature to inform the treatment of auditory processing dysfunction in adults, with emphasis on findings involving active or former military personnel. We were able to identify a limited number of studies, pertaining primarily to the treatment of auditory processing deficits through the use of assistive technologies and training strategies. We assessed the current state of the science for knowledge gaps that warrant additional study.

Conclusions:
Auditory processing deficits often co-occur with other military injuries and may pose significant risk in military operational and occupational settings. Research is needed to advance clinical diagnostic and rehabilitative capabilities, guide treatment planning, support effective multidisciplinary management, and inform fitness-for-duty standards. We emphasize the need for an inclusive approach to the assessment and treatment of auditory processing concerns in Service members and Veterans and for evidence-based solutions to address complex military risk factors and injuries.
Activity time series of old stars from late F to early K
Authors: Meunier N. , Pous R. , Sulis S. , Mary D. , Lagrange A.-M. 
Published: June 2023

Context. Stellar variability impacts radial velocities (hereafter RVs) at various timescales and therefore the detectability of exoplanets and the mass determination based on this technique. Detecting and characterising Earth-like planets in the habitable zone of solar-type stars represents an important challenge in the coming years, however. It is therefore necessary to implement systematic studies of this issue, for example to delineate the current limitations of RV techniques.
Aims. A first aim of this paper is to investigate whether the targeted 10% mass uncertainty from RV follow-up of transits detected by PLATO can be reached. A second aim of this paper is to analyse and quantify Earth-like planet detectability for various spectral types.
Methods. For this purpose, we implemented blind tests based on a large data set (more than 20 000) of realistic synthetic time series reproducing different phenomena leading to stellar variability such as magnetic activity patterns similar to the solar configuration as well as flows (oscillations, granulation, and supergranulation), covering F6-K4 stars and a wide range of activity levels.
Results. We find that the 10% mass uncertainty for a 1 MEarth in the habitable zone of a G2 star cannot be reached, even with an improved version of the usual correction of stellar activity (here based on a non-linear relation with log R′HK and cycle phase instead of a linear correlation) and even for long-duration (10 yr) well-sampled observations. This level can be reached, however, for masses above 3 MEarth or for K4 stars alone. We quantify the maximum dispersion of the RV residuals needed to reach this 10% level, assuming the activity correction method and models do not affect the planetary signal. Several other methods, also based on a correction using log R′HK in various ways (including several denoising techniques and Gaussian processes) or photometry, were tested and do not allow a significantly improvement of this limited performance. Similarly, such low-mass planets in the habitable zone cannot be detected with a similar correction: blind tests lead to very low detection rates for 1 MEarth and to a very high level of false positives. We also studied the residuals after correction of the stellar signal, and found significant power in the periodogram at short and long timescales, corresponding to masses higher than 1 MEarth in this period range.
Conclusions. We conclude that very significant and new improvements with respect to methods based on activity indicators to correct for stellar activity must be devised at all timescales to reach the objective of 10% uncertainty on the mass or to detect such planets in RV. Methods based on the correlation with activity indicators are unlikely to be sufficient.
Prevalence of Thyroid Peroxidase and Thyroglobulin Autoantibodies in
the Swedish Population
Authors: Bergemann Neele , Jonsdottir Berglind , Nilsson Anna-Lena , Lantz Mikael , Lind Alexander 
Published: June 2023

AbstractAutoimmune thyroid disease (AITD) may be detected prior to clinical symptoms
through the presence of autoantibodies against thyroid peroxidase (TPOab),
thyroglobulin (TGab), or both.The present study aimed to develop a novel radiobinding assay (RBA) for TPOab and
to determine the prevalence of TPOab and TGab in the Swedish population.Patient samples from 27 newly diagnosed Graves’ disease patients in
longitudinal follow-up and 124 AITD autoantibody-positive children in
prospective follow-up for increased risk of type 1 diabetes were included to
validate the novel RBA for TPO. The results of RBA were compared with those
obtained by commercial radioimmunoassay (RIA) and electrochemiluminescence
(ECL). Furthermore, 476 serum samples from adult blood donors and 297 from
13-year-old school children were analyzed for the presence of TPOab and
TGab.Receiver operating characteristics analysis for the novel TPOab resulted in an
area under curve (AUC) value of 0.82 (p<0.0001), a sensitivity of
77.8%, and a specificity of 91.9% in adult blood donors, and an
AUC value of 0.70 (p<0.0001), a sensitivity of 53.2% and a
specificity of 95.3% in the 13-year-old school children, respectively.
TPOab levels in RBA correlated with both ECL (r=0.8950,
p<0.0001) and RIA (r=0.9295, p<0.0001). The prevalence
of TPOab and TGab was 6.3% and 7.6% in adult blood donors and
2.9 and 3.7% in 13-year-old school children.In conclusion, a novel RBA for the determination of TPOab was developed and
validated with current methodologies. This study also reports an increasing
prevalence of thyroid autoantibodies from adolescence to adulthood.
Spinal Surgery in Patients with Type-1 Neurofibromatosis: A Comprehensive Review
Authors: Joaquim Andrei Fernandes 
Published: June 2023

AbstractType-1 neurofibromatosis (NF1) is a neurocutaneous syndrome classically known as peripheral NF to distinguish it from type-2 NF (central NF). Its main characteristic is the high predisposition to the growth of multiple tumors, which specially arouses the interest of spinal surgeons due to the presence of spinal cord compression and spinal deformities.Considering this, we have performed a comprehensive review, with illustrative cases of the main manifestations of NF1, focusing on the perspective of the spine surgeon. Articles were grouped according to the following subjects: diagnosis, skeletal complications, spinal deformity, and spinal tumors. For all of them, a detailed discussion on pearls for practice was presented.The diagnosis of NF1 is based on the presence of at least two out of seven criteria. Cutaneous findings are very common in NF1, and the most usual tumor is cutaneous neurofibroma (NFB). Plexiform neurofibromas are also found and present a high risk of becoming malignant peripheral nerve sheath tumors (MPNSTs), reducing life expectancy. Astrocytomas, especially pilocytic astrocytomas, are the most common central nervous system tumor, including in the spinal cord. Surgery is necessary to resect as much as possible without adding new neurological deficits. Spinal deformities are also commonly found (in 30–70% of the cases), potentially associated with dystrophic changes, which may result in acute and rapid progression.In the present review, we discuss specific characteristics found in this group of patients which are of paramount importance to properly manage this challenging disease.
What a Neurosurgeon Should Know About the Endolymphatic Sac: Part 3 – Ménière Disease
Authors: Vaz Marco Antônio Schlindwein , Monteiro Jander Moreira , Lavinsky Joel , Santis Giuseppe Casella , Filho Marcelo Assis Moro da Rocha , Ribas Carmen Austrália Paredes Marcondes , Araújo Ricardo Marques Lopes de , Figueiredo Eberval Gadelha , Isolan Gustavo Rassier 
Published: June 2023

Abstract
Objective To elucidate all the aspects that neurosurgeons should know about the Ménière disease (MD).
Methods Review of guidelines, books, and studies from 1933 to 2021, from basic to translational research, using human and animal endolymphatic sac (ES) tissue or cells, as well as reviews, case reports, and papers about surgical experience. This article is divided into three parts. In this last part, we review the MD.
Results The MD is one of the most common pathologies in the ES. It was first described by Prosper Ménière in 1861 with its clinical triad: dizziness, tinnitus, and hearing loss. A lot of theories relating ES to the MD have been proposed. Some of them postulate that it is caused by a narrowing and shortening in the endolymphatic duct, and others relate it to severe inflammation on the ES. Mostly due to the lack of understanding of this pathology, the diagnosis is mainly clinical, despite histopathology being helpful to confirm the diagnosis. The treatment of the MD can be done in 3 different ways: pharmacological, nonpharmacological, and surgical.
Conclusion The MD is one of the most common pathologies in the inner ear and has been largely studied over the years. The latest diagnosis guidelines must help in the classification and give better basis for diagnosis and treatment, which, despite not being curative yet, has improved over the years. Pharmacological treatment based on the possible etiologies, allied with proper diet and routine exercise, is showing promising results.
Neuroimaging of COVID-19
Authors: Kim Jisoo , Young Geoffrey S. 
Published: June 2023

AbstractWe review the wide variety of common neuroimaging manifestations related to coronavirus disease 2019 (COVID-19) and COVID therapies, grouping the entities by likely pathophysiology, recognizing that the etiology of many entities remains uncertain. Direct viral invasion likely contributes to olfactory bulb abnormalities. COVID meningoencephalitis may represent direct viral infection and/or autoimmune inflammation. Para-infectious inflammation and inflammatory demyelination at the time of infection are likely primary contributors to acute necrotizing encephalopathy, cytotoxic lesion of the corpus callosum, and diffuse white matter abnormality. Later postinfectious inflammation and demyelination may manifest as acute demyelinating encephalomyelitis, Guillain–Barré syndrome, or transverse myelitis. The hallmark vascular inflammation and coagulopathy of COVID-19 may produce acute ischemic infarction, microinfarction contributing to white matter abnormality, space-occupying hemorrhage or microhemorrhage, venous thrombosis, and posterior reversible encephalopathy syndrome. Adverse effects of therapies including zinc, chloroquine/hydroxychloroquine, antivirals, and vaccines, and current evidence regarding “long COVID” is briefly reviewed. Finally, we present a case of bacterial and fungal superinfection related to immune dysregulation from COVID.
Endoscopic Transsphenoidal Surgery of Pituitary Adenomas: Preliminary Results of the Neurosurgery Service of Hospital Cristo Redentor
Authors: Perondi Gerson , Mariante Afonso , Azambuja Fernando , Greggianin Gabriel Frizon , Dias Wanderson William dos Santos , Pinzetta Giulia 
Published: June 2023

Abstract
Objective The transsphenoidal surgery is a safe and effective technique to manage different skull base pathologies, such as pituitary adenomas. The purpose of the present study is to describe the initial experience with endoscopic transsphenoidal surgery in the treatment of pituitary adenoma patients at a tertiary hospital that is a reference in neurosurgery in Southern Brazil.
Materials and Methods We retrospectively analyzed data from 60 patients with pituitary adenoma who underwent endoscopic transsphenoidal surgery between 2012 and 2019. Demographic characteristics, type of tumor, baseline hormonal changes, and clinical presentation were reported, as well as postoperative outcomes, tumor resection rate, and complications.
Results The male/female ratio was of 0.53:1, and the mean age of the sample was of 54 (range: 26 to 79) years. In total, 34 patients (57%) presented the non-functioning adenoma subtype, and 26 (43%), the functioning adenoma subtype. In the non-functioning and functioning subtype groups, the average tumor diameter was of 32 mm and 18 mm, and the mean follow-up was of 27 months and 32 months respectively. Regarding visual symptoms, 79% of the patients showed improvement after surgery. Hormonal remission was achieved in 71% of the patients with prolactinoma, 85% of those with cushing, and 57% of patients with acromegaly. Overall, gross total resection (GTR) was achieved in 50% of patients but with a significantly lower rate among patients with tumors with parasellar growth (high grade on the Knosp classification). The most prevalent surgical complications observed were postoperative cerebrospinal fluid (CSF) leak and meningitis in 11% and 6% of the cases respectively.
Conclusion We have shown that transsphenoidal endoscopic surgery can produce good results in the management of pituitary adenomas, with acceptable peri- and postoperative morbidity and mortality. Regardless of the technique used, the presence of large and giant pituitary adenomas with a high Knosp grade represents an enormous challenge for contemporary neurosurgery.
Sectioning of the Filum Terminale in Patients with Chiari Malformation Type 1 Associated with Occult Tethered Cord Syndrome: Literature Review
Authors: Brito José Nazareno Pearce de Oliveira , Dantas Patryck Araújo , Bomfim Pedro Borges , Tavares Cléciton Braga , Martins Leonardo Augusto , Sousa Emerson Brandão , Cunha Michele Medeiros da 
Published: June 2023

AbstractApproximately 125 years ago, a group of pathologies now known as Chiari malformations was described for the first time. However, some mechanisms of its formation still remain unknown. A bibliographic survey was performed through a search in PubMed. In 1938, it was already theorized that an increase in spinal cord tension could be the cause of Chiari malformation type 1 (CM1) tonsillar herniation. In 1953, a condition known for the anchoring of the filum terminale to the vertebral canal was described for the first time and would later be known as tethered cord syndrome (TCS). Some studies have shown that it is associated with increased tension in the spinal cord, and this formed the basis for a possible pathophysiological explanation of tonsillar herniation. Case series emerged reporting that treatment for TCS with the sectioning of the filum terminale (SFT) could provide clinical improvement of patients with CM1. A new pathological entity emerged when it was realized that patients with the clinical picture of TCS could have the medullary cone in its normal position, differing from the caudal migration expected for the TCS. This condition became known as occult tethered cord syndrome (OTCS). Case series attempted to demonstrate its association with the origin of CM1, a non-intuitive association, since the cone in the normal position contradicts traction as a source of tonsillar herniation. To this day, the absence of randomized control trials limits any conclusions regarding the effectiveness of SFT for the treatment of patients with CM1.
Bridge Plate Distraction for Complex Distal Radius Fractures: A Cohort Study and Systematic Review of the Literature
Authors: Esworthy George P. , Shaji Vibha , Duraku Liron , Wu Feiran , Power Dominic M. 
Published: June 2023

Abstract
Background Dorsal bridge plating (DP) of the distal radius is used as a definitive method of stabilization in complex fracture configurations and polytrauma patients.
Questions/Purposes This review aims to summarize the current understanding of DP and evaluate surgical outcomes.
Methods Four databases were searched following the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines and registered with PROSPERO. Papers presenting outcome or complication data for DP were included. These were reviewed using the National Institutes of Health Quality Assessment and Methodological Index for Non-Randomised Studies tools. Results were collated and compared to a local cohort of DP patients.
Results Literature review identified 416 patients with a pooled complication rate of 17% requiring additional intervention. The most prevalent complications were infection/wound healing issues, arthrosis, and hardware failure. Average range of motion was flexion 46.5 degrees, extension 50.7 degrees, ulnar deviation 21.4 degrees, radial deviation 17.3 degrees, pronation 75.8 degrees, and supination 72.9 degrees. On average, DP removal occurred at 3.8 months. Quality assessment showed varied results.There were 19 cases in our local cohort. Ten displayed similar results to the systematic review in terms of range of motion and radiographic parameters. Higher QuickDASH scores and complication rates were noted. Local DP showed earlier plate removal at 2.9 months compared to previous studies.
Conclusion DP is a valid and useful technique for treating complex distal radius fractures. It displays a lower risk of infection and pain compared to external fixation which is commonly used to treat similar injuries. Patients can recover well following treatment both in function and range of motion. Further high-quality studies are required to fully evaluate the technique.
Spatiotemporal patterns and determinants of renewable energy innovation: Evidence from a province-level analysis in China
Authors: Ma Limei , Wang Qianying , Shi Dan , Shao Qinglong 
Published: June 2023

AbstractChina’s renewable energy innovation is essential for realizing its carbon neutrality targets and the low-carbon transition, but few studies have spatially examined its characteristics and spillover effects. To fill the research gap, this study investigates its distribution and trends from a spatiotemporal dimension and focuses on the spatial effects of the influencing factors to identify those that have a significant impact on renewable energy innovation by using China’s provincial panel data from 2006 to 2019. The results show the following findings. (1) Renewable energy innovation shows distinct spatial differences across China’s provinces such that it is high in the east and south and low in the west and north, which exhibits spatial locking and path-dependence. (2) There is a positive spatial correlation with renewable energy innovation. (3) R&D investment and GDP per capita significantly promote renewable energy innovation, but the former effect is mainly observed in the local area, whereas the latter shows spatial effects. More market-oriented policies should be taken for the improvement of renewable energy innovation and the establishment of regional coordination mechanisms are proposed.