bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physicochemical hazard assessment of ash and dome rock from the 2021 eruption of La Soufrière, St Vincent, for the assessment of respiratory health impacts and water contamination
Authors: Horwell C. J. , Damby D. E. , Stewart C. , Joseph E. P. , Barclay J. , Davies B. V. , Mangler M. F. , Marvin L. G. , Najorka J. , Peek S. , Tunstall N. 
Published: July 2023

Abstract
La Soufrière, St Vincent, began an extrusive eruption on 27 December 2020. The lava dome was destroyed, along with much of the pre-existing 1979 dome, in explosive eruptions from 9 to 22 April 2021. Lava domes generate crystalline silica – inhalation of which can cause silicosis in occupational settings – which can become hazardous when dome material is incorporated into volcanic ash.
La Soufrière ash (17 samples) was analysed, according to IVHHN protocols, to rapidly quantify crystalline silica and test for other health-relevant properties. The basaltic andesitic ash contained <5 wt% crystalline silica, which agrees with previous analyses of ash of similar compositions and mirrors the low quantities measured in dome samples (2 area %). It contained substantial inhalable material (7–21 vol% <10 µm). Few fibre-like particles were observed, reducing concern about particle shape. Leaching assays found low concentrations of potentially toxic elements, which indicates low potential to impact health, contaminate drinking-water sources or harm grazing animals through ingestion. Collectively, these data indicate that the primary health concern from this eruption was the potential for fine-grained ash to increase ambient particulate matter, an environmental risk factor for respiratory and cardiovascular morbidity and mortality. Precautionary measures were advised to minimize exposure.
Twin Identification over Viewpoint Change: A Deep Convolutional Neural Network Surpasses Humans
Authors: Parde Connor J. , Strehle Virginia E. , Banerjee Vivekjyoti , Hu Ying , Cavazos Jacqueline G. , Castillo Carlos D. , O’Toole Alice J. 
Published: July 2023

Deep convolutional neural networks (DCNNs) have achieved human-level accuracy in face identification (Phillips et al., 2018), though it is unclear how accurately they discriminate highly-similar faces. Here, humans and a DCNN performed a challenging face-identity matching task that included identical twins. Participants (
N
= 87) viewed pairs of face images of three types: same-identity, general imposters (different identities from similar demographic groups), and twin imposters (identical twin siblings). The task was to determine whether the pairs showed the same person or different people. Identity comparisons were tested in three viewpoint-disparity conditions: frontal to frontal, frontal to 45° profile, and frontal to 90° profile. Accuracy for discriminating matched-identity pairs from twin-imposter pairs and general-imposter pairs was assessed in each viewpoint-disparity condition. Humans were more accurate for general-imposter pairs than twin-imposter pairs, and accuracy declined with increased viewpoint disparity between the images in a pair. A DCNN trained for face identification (Ranjan et al., 2018) was tested on the same image pairs presented to humans. Machine performance mirrored the pattern of human accuracy, but with performance at or above all humans in all but one condition. Human and machine similarity scores were compared across all image-pair types. This item-level analysis showed that human and machine similarity ratings correlated significantly in six of nine image-pair types [range
r
= 0.38 to
r
= 0.63], suggesting general accord between the perception of face similarity by humans and the DCNN. These findings also contribute to our understanding of DCNN performance for discriminating high-resemblance faces, demonstrate that the DCNN performs at a level at or above humans, and suggest a degree of parity between the features used by humans and the DCNN.
Meningococcal ACWY conjugate vaccine immunogenicity in adolescents with primary or secondary immune deficiencies, a prospective observational cohort study
Authors: Ohm Milou , van Straalen Joeri W , de Joode-Smink Gerrie , van Montfrans Joris , Bartels Marije , van Wildenbeest Joanne G , Lindemans Caroline A , Wennink Roos AW , de Boer Joke H , Sanders Elisabeth AM , Verduyn-Lunel Frans M , Berbers Guy AM , Wulffraat Nico M , Jansen Marc H.A. 
Published: July 2023

Abstract
Background
Immunization with meningococcal ACWY conjugate vaccine induces protective antibodies against invasive meningococcal disease (IMD) caused by serogroups A, C, W and Y. We studied MenACWY-TT vaccine immunogenicity in adolescents with a heterogenous group of primary and secondary immune deficiency including patients with systemic lupus erythematosus, mixed connective tissue disease, vasculitis, uveitis, 22Q11 syndrome, sickle cell disease, and patients who underwent stem cell transplantation for bone marrow failure.

Findings
We enrolled 69 individuals aged 14–18 years diagnosed with a primary or secondary immune deficiency in a prospective observational cohort study. All patients received a single dose of MenACWY-TT vaccine during the catch-up campaign 2018-19 because of the IMD-W outbreak in the Netherlands. Capsular polysaccharide-specific (PS) IgG concentrations against MenACWY were measured before and 3–6, 12, and 24 months after vaccination. Overall, geometric mean concentrations (GMCs) of MenACWY-PS-specific IgG were lower in patients compared to data from healthy, aged-matched controls (n = 75) reaching significance at 12 months postvaccination for serogroup A and W (adjusted GMC ratios 0.26 [95% CI: 0.15–0.47] and 0.22 [95% CI: 0.10–0.49], respectively). No serious adverse events were reported by study participants.

Conclusions
The MenACWY conjugate vaccine was less immunogenic in adolescent patients with primary or secondary immunodeficiency compared to healthy controls, urging the need for further surveillance of these patients and supporting considerations for booster MenACWY conjugate vaccinations in these patient groups.
Evaluation of clinical outcomes, complication rate, feasibility, and applicability of transfacet pedicle-sparing approach in thoracic disc herniation: a systematic review and meta-analysis
Authors: Hamid Shafi , Moradi Farid , Bagheri Seyed Reza , Zarpoosh Mahsa , Amirian Parsa , Ghasemi Hooman , Alimohammadi Ehsan 
Published: July 2023

Abstract
Objective
This study aimed to evaluate the clinical outcomes, complication rate, feasibility, and applicability of transfacet pedicle-sparing approach for treating thoracic disc herniation.

Methods
We searched three databases including the Cochrane Library, PubMed, and Embase for eligible studies until Dec 2022. The quality of studies and their risk of bias were assessed using the methodological index for non‐randomized studies. We evaluated the heterogeneity between studies using the I2 statistic and the P-value for the heterogeneity.

Results
A total of 328 patients described in 11 included articles were published from 2009 to 2022. Pain outcomes using the visual analog scale (VAS score) were reported in four studies. The standardized mean difference was reported as 0.749 (CI 95% 0.555–0.943). The obtained result showed the positive effect of the procedure and the improvement of patients' pain after the surgery. Myelopathy outcomes using the Nurick score were reported in five studies. The standardized mean difference was reported as 0.775 (CI 95% 0.479–1.071). The result showed the positive effect of the procedure. Eight studies assessed postoperative complications and neurological deterioration. The pooled overall complication was 12.4% (32/258) and 3.5% (9/258) neurological worsening.

Conclusion
The results of this study demonstrated a positive effect of the transfacet pedicle-sparing approach on the clinical outcomes of patients with thoracic disc herniation surgery. The technique has been shown to be safe and effective for the right patient. The technique is associated with lower rates of complications and a shorter hospital stay compared to other surgical approaches. This information can assist clinicians in making informed decisions when selecting the most appropriate surgical technique for their patients with thoracic disc herniation.
Longitudinal multi-omics study of palbociclib resistance in HR-positive/HER2-negative metastatic breast cancer
Authors: Park Yeon Hee , Im Seock-Ah , Park Kyunghee , Wen Ji , Lee Kyung-Hun , Choi Yoon-La , Lee Won-Chul , Min Ahrum , Bonato Vinicius , Park Seri , Ram Sripad , Lee Dae-Won , Kim Ji-Yeon , Lee Su Kyeong , Lee Won-Woo , Lee Jisook , Kim Miso , Kim Hyun Seon , Weinrich Scott L. , Ryu Han Suk , Kim Tae Yong , Dann Stephen , Kim Yu-Jin , Fernandez Diane R. , Koh Jiwon , Wang Shuoguo , Park Song Yi , Deng Shibing , Powell Eric , Ravi Rupesh Kanchi , Bienkowska Jadwiga , Rejto Paul A. , Park Woong-Yang , Kan Zhengyan 
Published: July 2023

AbstractBackgroundCyclin-dependent kinase 4/6 inhibitor (CDK4/6) therapy plus endocrine therapy (ET) is an effective treatment for patients with hormone receptor-positive/human epidermal receptor 2-negative metastatic breast cancer (HR+/HER2− MBC); however, resistance is common and poorly understood. A comprehensive genomic and transcriptomic analysis of pretreatment and post-treatment tumors from patients receiving palbociclib plus ET was performed to delineate molecular mechanisms of drug resistance.MethodsTissue was collected from 89 patients with HR+/HER2− MBC, including those with recurrent and/or metastatic disease, receiving palbociclib plus an aromatase inhibitor or fulvestrant at Samsung Medical Center and Seoul National University Hospital from 2017 to 2020. Tumor biopsy and blood samples obtained at pretreatment, on-treatment (6 weeks and/or 12 weeks), and post-progression underwent RNA sequencing and whole-exome sequencing. Cox regression analysis was performed to identify the clinical and genomic variables associated with progression-free survival.ResultsNovel markers associated with poor prognosis, including genomic scar features caused by homologous repair deficiency (HRD), estrogen response signatures, and four prognostic clusters with distinct molecular features were identified. Tumors withTP53mutations co-occurring with a unique HRD-high cluster responded poorly to palbociclib plus ET. Comparisons of paired pre- and post-treatment samples revealed that tumors became enriched in APOBEC mutation signatures, and many switched to aggressive molecular subtypes with estrogen-independent characteristics. We identified frequent genomic alterations upon disease progression inRB1,ESR1, PTEN, andKMT2C.ConclusionsWe identified novel molecular features associated with poor prognosis and molecular mechanisms that could be targeted to overcome resistance to CKD4/6 plus ET.Trial registrationClinicalTrials.gov, NCT03401359. The trial was posted on 18 January 2018 and registered prospectively.
Long Covid active case finding study protocol: A co-produced community-based pilot within the STIMULATE-ICP study (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways)
Authors: Alwan Nisreen A. , Clutterbuck Donna , Pantelic Marija , Hayer Jasmine , Fisher Lere , Hishmeh Lyth , Heightman Melissa , Allsopp Gail , Wootton Dan , Khan Asad , Hastie Claire , Jackson Monique , Rayner Clare , Brown Darren , Parrett Emily , Jones Geraint , Smith Kerry , Clarke Rowan , Mcfarland Sammie , Gabbay Mark , Banerjee Amitava ,   for the STIMULATE-ICP Consortium
Published: July 2023

Background and aim
Long Covid is a significant public health concern with potentially negative implications for health inequalities. We know that those who are already socially disadvantaged in society are more exposed to COVID-19, experience the worst health outcomes and are more likely to suffer economically. We also know that these groups are more likely to experience stigma and have negative healthcare experiences even before the pandemic. However, little is known about disadvantaged groups’ experiences of Long Covid, and preliminary evidence suggests they may be under-represented in those who access formal care. We will conduct a pilot study in a defined geographical area in London, United Kingdom to test the feasibility of a community-based approach of identifying Long Covid cases that have not been clinically diagnosed and have not been referred to Long Covid specialist services. We will explore the barriers to accessing recognition, care, and support, as well as experiences of stigma and perceived discrimination.

Methods
This protocol and study materials were co-produced with a Community Advisory Board (CAB) made up primarily of people living with Long Covid. Working with voluntary organisations, a study leaflet will be distributed in the local community to highlight Long Covid symptoms and invite those experiencing them to participate in the study if they are not formally diagnosed. Potential participants will be assessed according to the study’s inclusion criteria and offered the opportunity to participate if they fit them. Awareness of Long Covid and associated symptoms, experiences of trying to access care, as well as stigma and discrimination will be explored through qualitative interviews with participants. Upon completion of the interviews, participants will be offered a referral to the local social prescribing team to receive support that is personalised to them potentially including, but not restricted to, liaising with their primary care provider and the regional Long Covid clinic.
Stroke services in MENA: What is there and what is needed
Authors: Aref Hany , El Nahas Nevine , Alrukn Suhail Abdulla , Khan Maria , Kesraoui Selma , Alnidawi Firas , Hokmabadi Elyar Sadeghi , Farhoudi Mehdi , Fairooz Muataz , Batayha Waleed , Salmeen Athari , Abdulrahman Husen , Belahsen Mohammed Faouzi , Al Hashmi Amal M. , Akhtar Naveed , Al-Johani Mohammed , Seidi Osheik Abu’Asha , Jouhar Anas , Mhiri Chokri , Elbassiouny Ahmed , Shokri Hossam , Roushdy Tamer 
Published: July 2023

Objectives
Stroke represents a health care challenge to most parts of the world including the Middle East and North Africa (MENA) region. The MENA represents 6% of the world population with an age-standardized stroke rate of 87.7 (78.2–97.6) per 100,000 population. This number is subject to increase given that the cause of morbidity has recently shifted from infectious diseases to non-communicable diseases. Thus, in the coming years, treatment of stroke will pose a major burden on MENA countries which mostly lie in the low to middle income economies. Accordingly, we need to study the state of MENA stroke services in order to recognize and further inform policy makers about any gaps that need to be bridged in this domain.

Methods and results
Stroke specialists representing 16 countries filled an online survey that included: screening for risk factors, acute management, diagnostics, medications, post-discharge services, and stroke registries. Results showed that 11 countries screen for risk factors, 16 have neuroimaging studies, 15 provide intravenous thrombolysis (IVT), 13 mechanical thrombectomy (MT) while medications for secondary prevention are available in all countries. However, stroke units are not equally available and even absent in 4 countries, and despite the availability of IVT yet, the rate of administration is still low in 6 countries (<5%), and ranges from 5–20% in 7 countries. Stroke registries and training still need to be implemented in most countries.

Conclusion
Although imaging, revascularization therapies and medications for secondary prevention are available in most MENA countries, yet the rate of revascularization is low, so is the number of stroke units insufficient in some countries. Additionally, registries and structured training are still defective. Further field studies are required for more accurate determination of the status of stroke services in the MENA region.
Exome sequencing reveals IFT172 variants in patients with non-syndromic cholestatic liver disease
Authors: Neřoldová Magdaléna , Ciara Elżbieta , Slatinská Janka , Fraňková Soňa , Lišková Petra , Kotalová Radana , Globinovská Janka , Šafaříková Markéta , Pfeiferová Lucie , Zůnová Hana , Mrázová Lenka , Stránecký Viktor , Vrbacká Alena , Fabián Ondřej , Sticová Eva , Skanderová Daniela , Šperl Jan , Kalousová Marta , Zima Tomáš , Macek Milan , Pawlowska Joanna , Knisely A. S. , Kmoch Stanislav , Jirsa Milan 
Published: July 2023

Background and aim
Gene defects contribute to the aetiology of intrahepatic cholestasis. We aimed to explore the outcome of whole-exome sequencing (WES) in a cohort of 51 patients with this diagnosis.

Patients and methods
Both paediatric (n = 33) and adult (n = 18) patients with cholestatic liver disease of unknown aetiology were eligible. WES was used for reassessment of 34 patients (23 children) without diagnostic genotypes in ABCB11, ATP8B1, ABCB4 or JAG1 demonstrable by previous Sanger sequencing, and for primary assessment of additional 17 patients (10 children). Nasopharyngeal swab mRNA was analysed to address variant pathogenicity in two families.

Results
WES revealed biallelic variation in 3 ciliopathy genes (PKHD1, TMEM67 and IFT172) in 4 clinically unrelated index subjects (3 children and 1 adult), heterozygosity for a known variant in PPOX in one adult index subject, and homozygosity for an unreported splice-site variation in F11R in one child. Whereas phenotypes of the index patients with mutated PKHD1, TMEM67, and PPOX corresponded with those elsewhere reported, how F11R variation underlies liver disease remains unclear. Two unrelated patients harboured different novel biallelic variants in IFT172, a gene implicated in short-rib thoracic dysplasia 10 and Bardet-Biedl syndrome 20. One patient, a homozygote for IFT172 rs780205001 c.167A>C p.(Lys56Thr) born to first cousins, had liver disease, interpreted on biopsy aged 4y as glycogen storage disease, followed by adult-onset nephronophthisis at 25y. The other, a compound heterozygote for novel frameshift variant IFT172 NM_015662.3 c.2070del p.(Met690Ilefs*11) and 2 syntenic missense variants IFT172 rs776310391 c.157T>A p.(Phe53Ile) and rs746462745 c.164C>G p.(Thr55Ser), had a severe 8mo cholestatic episode in early infancy, with persisting hyperbilirubinemia and fibrosis on imaging studies at 17y. No patient had skeletal malformations.

Conclusion
Our findings suggest association of IFT172 variants with non-syndromic cholestatic liver disease.
Sentiment Analysis on Social Media Against Public Policy Using Multinomial Naive Bayes
Authors: Zulfikar Wildan Budiawan , Atmadja Aldy Rialdy , Pratama Satrya Fajri 
Published: July 2023

Purpose: The purpose of this study is to analyze text documents from Twitter about public policies in handling COVID-19 that are currently or have been determined. The text documents are classified into positive and negative sentiments by using Multinomial Naive Bayes.Methods: In this research, CRISP-DM is used as a method for conducting sentiment analysis, starting from the business understanding process, data understanding, data preparation, modeling, and evaluation. Multinomial Naive Bayes has been applied in building classification based on text documents. The results of this study made a model that can be used in classifying texts with maximum accuracy.Result: The results of this research are focused on the model or pattern generated by the Multinomial Naive Bayes Algorithm. The classification results of social media users' tweets against the new normal policy obtained good results with an accuracy value of 90.25%. After classifying the tweets of social media users regarding the new normal policy, the results show that more than 70% agreed and supported the new normal policy.Novelty: This study resulted in how classification can be done with Multinomial Naive Bayes and this algorithm can work well in recognizing text sentiments that generate positive or negative opinions regarding public policies handling COVID-19. So, the research provided conclusions about the views of people around the world on new normal public policy.
STUDY ON THE TENDENCY OF ACCRETION AND EROSION IN THE CAN GIO COASTAL ZONE
Authors: Bay Nguyen Thi , Phung Nguyen Ky 
Published: July 2023

This paper presents the studies on the numerical models to simulate the currents, sediment transport by tide and wind. The results from the models are used to estimate the tendency of accretion and erosion in the Can Gio coastal zone. The basic theory in the numerical models is Reynolds equation system combined with the sediment transport equation and the conservation equation for sediment mass. The computational results of the mass concentration of sediment and the tendency of accretion and erosion in the studied area are in agreement with the satellite photos.
What Was the Level of Ground Motion across Europe during the Great A.D. 365 Crete Earthquake?
Authors: Causse Mathieu , Maufroy Emeline , André Lucile , Bard Pierre-Yves 
Published: July 2023

Abstract
Historical and archeological data report that an earthquake was felt over the whole eastern Mediterranean on 21 July A.D. 365. The impact of the tsunami it generated, which may have caused several thousands of fatalities, has been widely studied, whereas the impact of the seismic waves has hardly been explored. Here, we present simulations of the ground motion caused by the A.D. 365 event at 316 sites now instrumented by seismological stations throughout Europe. The simulation approach is based on the modeling of a series of rupture scenarios coupled with empirical Green’s functions (EGFs) obtained at the stations from a recent Mw 6.4 earthquake. The broadband and remarkably also the accelerometric records in urbanized areas can be exploited at distances as far as ∼2000 km. Then, we use three empirical models to estimate the macroseismic intensity across Europe from the simulated peak ground accelerations and peak ground velocities. The presence of stations in thick sedimentary basins (lower Danube valley, Po plain, urban accelerometric network in the alpine valley of Grenoble) shows that local basin amplification effects can dominate acceleration values at frequencies favorable to human earthquake perception (~0.5–1 Hz), even for basins located at more than 1500 km from the earthquake. Thus, our simulations indicate that the A.D. 365 earthquake was likely felt by the populations as far as the Po plain and as the city of Grenoble, about 1800 km away, and presumably in other large European basins such as the Pannonian basin. It is possible that the perception of the earthquake up to such distances contributed to its “universal” character perpetuated in archival sources. At closer distances (300–500 km), the simulated intensity levels indicate that the earthquake probably caused no damage.
Perceived Impact of a Relationship-Based Care Curriculum
Authors: Haertl Kristine Lynn , Theismann Alexandra 
Published: July 2023

Purpose: Authentic client-centered practice is integral to positive health-care outcomes. This study examined facilitator perspectives of the See Me as a Person (SMAAP) relationship-based health-care curriculum. Methods Qualitative phenomenological interviews were conducted with five facilitators of the SMAAP curriculum. The principal question and sub questions explored the facilitation and teaching methods, perceived impact of the curriculum, and the impact on healthcare practice. Findings The concepts in the SMAAP curriculum are translatable into practice and may improve health care; organizational culture, leadership, and time constraints influence impact. Conclusion Relationship-based practice training can positively affect health-care delivery. Practitioners must be dedicated to the learning process; implementation should go beyond short-term training.