bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid, field-deployable method for determination of seafood decomposition by compact mass spectrometry
Authors: Self Randy , McLendon Michael , Lock Christopher , Hu Jinxin 
Published: April 2023

Seeking alternatives to sensory which can be performed in non-laboratory field environments has been a recent emphasis in regulatory assessment of seafood decomposition. To this end, an international sampling effort produced samples of 23 different seafood products, which were subjected to controlled decomposition of varying levels on ice. This produced samples of each product for a wide range of decomposition states, and these were scored by a sensory expert on a standard 1-100 scale. Samples were then analyzed by a novel technique involving headspace analysis and compact mass spectrometry. The mass spectrometry data was used to create computer models, guided by the sensory data, to generate a calculated score analogous to a sensory score. Models based on a training set of samples were then used to calculate scores for a test set, and accuracy was assessed by comparing these calculated scores to original sensory data. Calculated scores agreed with sensory findings with respect to overall decomposition state for 96.3% of samples (n=547), with seven false positive (1.3%) and 13 false negative (2.4%) findings. Reproducibility was also assessed via triplicate analysis on separate days for low, middle, and high decomposition states. All sample ranges for these replicates were within 20 points, with 89% (n=66) within 15 points, 73% within 10, and 35% within five. Given the performance of the method, along with the small form factor and manageable operation requirements of the instrument as well as simplicity of sample preparation, this appears to offer a potentially useful technique for field testing of seafood decomposition.
Aflatoxin Sampling and Testing Proficiency in the Texas Grain Industry
Authors: Herrman Timothy J. , Lee Kyung-Min , Jones Benjamin , McCormick Cynthia 
Published: April 2023

Aflatoxin is a group I carcinogen and represents a significant public health and food safety risk throughout the world. Aflatoxin contaminated cereals and oilseeds that contain greater than 20 μg/kg of the toxin (B1, B2, G1, G2) are defined as adulterated by the Texas Commercial Feed Rules and are regulated by the Texas Feed and Fertilizer Control Service. This study was performed to assess sampling and testing of maize for aflatoxin contamination. During 2010, 87 Texas grain elevators’ sampling procedures were assessed and a second investigation documented aflatoxin analysis procedures at 41 grain elevator establishments. The average sample size was 1.8 kg (4 pounds) and fewer than 20% of the grain elevators collected samples using an official (prescribed) sampling pattern by the grain inspection, crop insurance or regulatory authorities within the United States. Proficiency samples were analyzed by 39 cooperating grain elevators and 7 firms accurately analyzed samples containing greater than 300 μg/kg aflatoxin. While sampling contributes to variability in measuring aflatoxin in grain, this study highlights that aflatoxin analysis using commercially available test kits is a major contributor to variation in aflatoxin test results among commercial grain handlers.
Impact assessment of climate change on water resources of the Kokcha watershed: a sub-basin of the Amu Darya river basin in Afghanistan
Authors: Alawi Sayed Amir , Özkul Sevinç 
Published: April 2023

Abstract

Climate change is one of the most concerning issues which mostly impacts water resources. This study aimed to investigate the Kokcha watershed under the effects of climate change. The study was performed utilizing the Soil and Water Assessment Tool (SWAT) considering the Representative Concentration Pathway (RCP4.5 and RCP8.5) scenarios in the periods of 2050–2059 and 2090–2099. The Model for Interdisciplinary Research on Climate (MIROC5) from the Coupled Model Intercomparison Project Phase 5 (CMIP5) was used to prepare future climate data. The temperature indicated a rising of +2.47 and +2.85 °C in 2050–2069 considering RCP4.5, and +3.38 and +5.51 °C based on the RCP8.5 scenario through 2080–2099. Precipitation showed a −30 and −17.17% decrease based on RCP4.5, and a decrease of −9.28 and −4.52% considering RCP8.5 in the mentioned periods, respectively. The historical runoff peak shifted a month earlier with a −54.56 and −25.98% decrease considering RCP4.5 and a −29.18 and −6.45% based on the RCP8.5 scenario in the mid and end of the century accordingly. Alternatively, a second river flow peak takes shape due to rainfall in July. This study's result can be used to adapt water management to climate change in the Kokcha watershed and similar regions.
Piperidine Nucleus as a Promising Scaffold for Alzheimer’s Disease:
Current Landscape and Future Perspective
Authors: Grover Parul , Rohilla Suman , Bhardwaj Monika , Mehta Lovekesh , Malhotra Anjleena 
Published: April 2023

Abstract:
Heterocycles and their derivatives hold an important place in medicinal chemistry due to
their vast therapeutic and pharmacological significance and wider implications in drug design and
development. Piperidine is a nitrogen-containing heterocyclic moiety that exhibits an array of
pharmacological properties. This review discusses the potential of piperidine derivatives against the
neurodegenerative disease Alzheimer’s. The incidences of Alzheimer’s disease are increasing nowadays,
and constant efforts are being made to develop a medicinal agent for this disease. We have
highlighted the advancement in developing piperidine-based anti-neuronal disease compounds and
the profound activities of some major piperidine-bearing drug molecules with their important target site.

:
This review focuses on advancements in the field of natural and synthetic occurring piperidines active
against Alzheimer’s disease, with emphasis on the past 6 years. The discussion also includes
the structure-activity relationship, the structures of the most promising molecules, and their biological
activities against Alzheimer’s disease. The promising activities revealed by these piperidinebased
scaffolds undoubtedly place them at the forefront of discovering prospective drug candidates.
Thus, it would be of great interest to researchers working on synthesizing neuroprotective drug candidates.
Pericholecystic Varices as the Predominant Manifestation in Cryptogenic Portal
Hypertension: A Case Report
Authors: Tong Meng , Gao Yanli , Jia Feiyu , Liu Jinghua 
Published: April 2023

Background:
Portal hypertension has various manifestations, and varices are a common manifestation. Varices can appear in any vein in the body associated with the portal venous system.

Case Presentation:
Herein, we report a case of portal hypertension with gallbladder varices as the main manifestation, which was confirmed by abdominal contrast-enhanced CT with three-dimensional reconstruction and color Doppler ultrasonography. The patient had concomitant liver cirrhosis and portal vein thrombosis. Various auxiliary examinations and biochemical indicators of the patient confirmed liver cirrhosis, portal vein thrombosis, and portal hypertension, all of which were mild and did not reach the decompensation stage.

Conclusion:
As illustrated by this case, when there is an embolism in certain parts of the portal system, portal hypertension can appear during the compensatory period and transition into severe varices in the thrombotic part during the de-compensatory period.
Hollow Fiber Carbon Molecular Sieve Membranes for Gas Separation: A Mini Review
Authors: Nie Jing , Li Haibo 
Published: April 2023

Abstract:
Owing to the advantages of rapid adsorption and desorption characteristics, excellent
gas separation performance, as well as good thermal and chemical resistance, carbon molecular
sieve (CMS) membranes have been developed as a promising gas separation tool. Over the past 30
years, hollow fiber carbon molecular sieve (HFCMS) membranes have become the preferred
choice for industrial applications due to their high surface area-to-volume ratio and the ability to
assemble lightweight membrane modules. The gas transport mechanism behind the HFCMS is
dominated by molecular sieving function. They can be prepared by pyrolysis of the polymeric
hollow fiber precursors. Post-treatments can tailor the ultramicropores structure to improve the
separation performance. This paper aims to review the recent progress in the preparation of
HFCMS membranes from aspects of precursor selection, pyrolysis conditions and post-treatment.
Moreover, a brief perspective in terms of future investigation of HFCMS membrane is also proposed.
Advances in Two-dimensional (2D) Inorganic Chiral Materials and 2D
Organic-inorganic Hybrid Chiral Materials
Authors: Zhang Wenyan , Guan Hangmin , Hu Yingfei , Wang Wei , Liu Fei , Yang Xiaoli , Hao Lingyun 
Published: April 2023

Abstract:
Recently, two-dimensional (2D) materials have gained immense attention, as they are
promising in various application fields, such as energy storage, thermal management, photodetectors,
catalysis, field-effect transistors, and photovoltaic modules. These merits of 2D materials are
attributed to their unique structure and properties. Chirality is an intrinsic property of a substance,
which means the substance can not overlap with its mirror image. Significant progress has been
made in chiral science, for chirality uniquely influences a chiral substance's performance. With the
rapid development of chiral science, it became unveiled that chirality not only exists in chiral organic
molecules but can also be induced in 2D inorganic materials and 2D organic-inorganic hybrid
materials by breaking the chiral symmetry within their framework to form 2D chiral materials.
Compared with 2D materials that do not have chirality, these 2D inorganic chiral materials and 2D
organic-inorganic hybrid chiral materials exhibit innovative performance due to chiral symmetry
breaking. Nevertheless, at present, only a fraction of work is available which comprehensively
sums up the progress of these promising 2D chiral materials. Thus, given their high potential, it is
urgent to summarize these newly developed 2D chiral materials comprehensively. In the current
study, to feature and highlight their major significance, the recent progress of 2D inorganic materials
and 2D organic-inorganic hybrid materials from their chemical composition and categories, application
potential associated with their unique properties, and present synthesis strategies to fabricate
them along with discussion concerning the development challenges and their bright future
were reviewed. This review is anticipated to be instructive and provide a high understanding of advanced
functional 2D materials with chirality.
Current Status of Imaging Diagnosis and Treatment of Subcentimeter
Hepatocellular Carcinoma
Authors: Huang Peng , Xiao Yuyao , Zhou Changwu , Wu Fei , Yang Chun , Zeng Mengsu 
Published: April 2023

Abstract:
Significant advances in liver imaging technology have facilitated the early detection of
subcentimeter hepatocellular carcinoma (HCC). Contrast-enhanced ultrasound, computed tomography,
and magnetic resonance imaging (MRI) can be used to diagnose subcentimeter HCC
based on the typical imaging features of HCC. Ancillary imaging features such as T2 weightedimaging
mild-moderate hyperintensity, restricted diffusion, and hepatobiliary phase hypointensity
may improve the diagnostic accuracy of gadoxetic acid-enhanced MRI for subcentimeter
HCC. More information is needed to choose between immediate treatment or watchful waiting in
subcentimeter HCC. Surgical resection, ablation, and transarterial chemoembolization are effective
and safe methods for the management of subcentimeter HCC.
Liquid Biopsy for Early Diagnosis of Hepatocellular Carcinoma: Current
State and Future Perspectives
Authors: Jiang Huiqin , Yang Wenjing , Jin Anli , Wang Hao , Li Tong , Xian Jingrong , Chen Wei , Ding Ling , Wang Beili , Guo Wei 
Published: April 2023

Abstract:
Liquid biopsies in cancer have received considerable attention as new biomarkers and
subjects of clinical translational research. Liquid biopsy-derived biomarkers, including circulating
tumor cells, cell-free nucleic acids, exosomes, tumor-educated platelets, proteins, and metabolites,
have shown enormous potential to improve the sensitivity and specificity in early diagnosis of multiple
cancer types, including hepatocellular carcinoma (HCC). Several analytes are already used in
HCC clinical trials and are currently under investigation with encouraging preliminary results. This
article will review the latest studies on liquid biopsy for early diagnosis and screening of HCC and
discuss the current advantages and challenges of liquid biopsies in tumor biomarkers and clinical
applications. In the future, the validation of large prospective clinical studies, the development of
standardized operating procedures, and the integration of other diagnostic tools will open new avenues
for applying liquid biopsy in early cancer detection.
Biological Importance and Therapeutic Potential of Calycopterin
from Dracocephalum kotschyi: An Overview of Current Scientific
Research Work
Authors: Patel Dinesh Kumar , Patel Kanika 
Published: April 2023

Background:
Dracocephalum kotschyi Boiss is an important medicinal plant of
Asia, Europe and Iran. The therapeutic potential of Dracocephalum kotschyi has been mentioned
in traditional as well as in modern medicine, mainly due to its therapeutic effectiveness
against different types of human disorders and associated secondary complications.
Calycopterin is a flavonoid class phytochemical commonly called 5,4-dihydroxy-3,6,7,8-
tetramethoxyflavone, which has been isolated from Dracocephalum kotschyi. It is widely
used for the treatment of human disorders and associated secondary complications. Medicinal
importance and therapeutic potential of calycopterin was investigated in the present work
through scientific data analysis of different research works. Scientific data on calycopterin
published in different research articles were collected from PubMed, Google, Google Scholar,
Science Direct, SpringerLink, and Scopus and analyzed in the present work. Further, scientific
data was also collected from books and book chapters. Analytical data on calycopterin
was also collected and analyzed in the present work. Scientific data analysis of different
research work revealed the biological importance and therapeutic potential of calycopterin.
Calycopterin showed therapeutic effectiveness against different types of cancerous disorders,
including human prostate cancer, breast cancer, cervical cancer, lymphocyte proliferation
and hepatoblastoma cancer. Moreover, the biological effectiveness of calycopterin on neuroprotection
and Pseudomonas aeruginosa has also been discussed in the present work with
their pharmacokinetic parameters. Nevertheless, more scientific investigations must be conducted
to explore the health-beneficial aspects of calycopterin in medicine. Present work
signified the biological importance and therapeutic potential of calycopterin for the treatment
of human disorders and complications, including different types of cancerous disorders.
La educación frente a las desigualdades: reflexiones y propuestas de acción desde un análisis y experiencia comparativos entre México y España
Authors: Jasso Alfieri Romina Denise 
Published: April 2023

El presente trabajo es el resultado de la intervención de su autora en la mesa de diálogo Retos de la educación en Iberoamérica en el siglo xxi, celebrada el 24 de noviembre de 2021 en el marco del I Encuentro del Pensamiento Iberoamericano, el cual tuvo lugar en la Universidad Internacional de Andalucía, campus La Rábida. El nombre elegido para la mesa dio comienzo a una reflexión profunda sobre lo que podemos entender por la educación, porque la realidad nos demuestra que no podemos hablar de ella en singular, sino que tenemos que hablar de una serie de educaciones, un heterogéneo número de aproximaciones públicas y privadas a la promoción del aprendizaje de niños, jóvenes y adultos que forman parte de los países iberoamericanos.
Se puede pensar que este mosaico de formas de concebir y de promover el aprendizaje y, a su vez, el desarrollo personal y social, está enmarcado a nivel nacional, y que los países, al ser tan diversos los unos de los otros, tienen maneras distintas de concebir la realidad educativa para la totalidad de su territorio. Sin embargo, al hacer un análisis al interior de cada país, nos daremos cuenta de que el mosaico es igualmente diverso internamente, lo que se debe primordialmente a que la educación es el reflejo de sociedades diversas y desiguales, siendo también promotora de dichas desigualdades debido, en gran parte, a la creciente presencia de la educación privada y a la creciente sectorización de la educación pública, que es sumamente distinta dependiendo de las características del contexto de la escuela (el barrio, la zona de la ciudad, la región nacional, el espacio geopolítico internacional, etc.).
PERPAJAKAN TERHADAP INSENTIF PPH FINAL ATAS KEPATUHAN WAJIB PAJAK UMKM DI KABUPATEN BADUNG
Authors: Sukasih N. K. 
Published: April 2023

Masa COVID-19 di tahun 2020-2021 ini sektor UMKM yang berpotensi dalam menggerakkan perekonomian masyarakat Indonesia. Penurunan kesetabilan perekonomian akibat wabah Covid-19 pemerintah mengupayakan peningkatan stabilitas perekonomian dan kepatuhan wajib pajak UMKM dengan menetapkan kebijakan Peraturan Menteri Keuangan (PMK) yaitu pemberian insentif PPh final. Penelitian ini bertujuan untuk mengetahui penerapan perpajakan terhadap Insentif PPh final atas kepatuhan wajib pajak UMKM di Kabupaten Badung. Metode penelitian yang digunakan pada penelitian adalah metode penelitian kuantitatif dengan pendekatan deskriptif kualitatif . Populasi pada penelitian ini adalah Wajib Pajak UMKM di Kabupaten Badung. Metode penarikan sampel dilakukan dengan purposive sampling dan diperoleh jumlah sampel sebanyak 95 orang responden. Data kemudian dianalisis dengan beberapa analisis meliputi uji statistik deskriptif, uji validitas, uji reliabilitas, uji asumsi klasik, uji koefisien determinasi (R2), uji regresi linier berganda, uji t dan uji F dengan penyajian data dibantu program SPSS 26.0. Hasil penelitian ini menyatakan pemahaman perpajakan dan insentif PPh final memiliki pengaruh positif terhadap kepatuhan wajib pajak UMKM.
Publicação continuada: mais rapidez no processo de divulgação do conhecimento científico
Authors: Chapani Daisi Teresinha 
Published: April 2023

A divulgação do conhecimento científico por meio de publicações periódicas remonta ao século XVII. Desde então, essa forma de comunicação tem passado por transformações em virtude das alterações nas práticas científicas e do desenvolvimento tecnológico. Contudo, desde sua criação, os periódicos científicos apresentam como uma de suas mais marcantes características a celeridade na divulgação do conhecimento. Esse foi um fator importante para o sucesso dos periódicos como meio de comunicação científica. Assim, tendo em vistas as facilidades oferecidas pelo sistema de editoração de revistas, a RID passa, a partir deste ano, a publicar os artigos de forma contínua. Isso significa que eles serão publicados tão logo se concluam os processos de avaliação, revisão e editoração, sem necessidade de se aguardar o fechamento do número.
Circulating long noncoding RNA signatures associate with incident diabetes in older adults: a prospective analysis from the VITA cohort study
Authors: Wenzl Florian A. , Mengozzi Alessandro , Mohammed Shafeeq A. , Pugliese Nicola Riccardo , Mongelli Alessia , Gorica Era , Ambrosini Samuele , Riederer Peter , Fischer Peter , Hinterberger Margareta , Puspitasari Yustina , Lüscher Thomas F. , Camici Giovanni G. , Matter Christian M. , Fadini Gian Paolo , Virdis Agostino , Masi Stefano , Ruschitzka Frank , Grünblatt Edna , Paneni Francesco , Costantino Sarah 
Published: April 2023

<p> </p>
<p><strong>Objective:</strong> Long noncoding RNAs (lncRNAs) are involved in diabetogenesis in experimental models yet their role in humans is unclear. We investigated whether circulating lncRNAs associate with incident type 2 diabetes in older adults.</p>
<p><strong>Research Design and Methods: </strong>A preselected panel of lncRNAs was measured in serum of individuals without diabetes (<em>n</em>=296) from the VIenna Transdanube Aging (VITA) study, a prospective community-based cohort study. Participants were followed-up over 7.5 years. A second cohort of individuals with and without type 2 diabetes (<em>n</em>=90) was employed to validate our findings.</p>
<p><strong>Results:</strong> Four lncRNAs (ANRIL, MIAT, RNCR3, and PLUTO) were associated with incident type 2 diabetes and linked to HbA1c trajectories throughout the 7.5-year follow-up. Similar results (for MIAT and PLUTO also in combined analysis) were obtained in the validation cohort.</p>
<p><strong>Conclusion:</strong> We found a set of circulating lncRNAs which independently portends incident type 2 diabetes in older adults years before disease onset.</p>
Intraoperative ICG-Fluorescence Imaging of Lymph Nodes in Robot-Assisted Radical Cystectomy in Patients with Bladder Cancer
Authors: Pavlov V. N. , Urmantsev M. F. , Bakeev M. R. 
Published: April 2023

Introduction. Bladder cancer dominates among global health problems. Radical cystectomy is the recognized standard of care for muscle-invasive bladder cancer with bilateral pelvic lymphadenectomy as a mandatory step in the surgical procedure. The concept of sentinel lymph nodes, acting as a barrier to the spread of malignant process, can be beneficial in terms of reducing the extent of pelvic lymphadenectomy. Intraoperative imaging using indocyanine green now appears to be a contemporary and relevant method for intraoperative imaging of sentinel lymph nodes. Materials and methods. A study involving 28 patients diagnosed with bladder cancer was carried out at the clinic of the Bashkir State Medical University. All patients underwent robot-assisted radical cystectomy with intracorporeal formation of a heterotopic neobladder using Bricker technique. At the stage of pelvic lymphadenectomy, the isolated lymph nodes were evaluated and intraoperative ICG-fluorescence was performed. All lymph nodes obtained were examined microscopically and the results were interpreted taking into account the intraoperative diagnosis. Results and discussion. Intraoperative ICG fluorescence identified sentinel lymph nodes in 7 of 9 patients (77.8%, p < 0.05), with sensitivity equal to 77.8%, p < 0.05 and specificity — 87.5%, p < 0.05. Conclusion. The results proved a high reliability of the method of intraoperative lymph nodes imaging with indocyanine green in patients with muscle-invasive bladder cancer. Fluorescence navigation in cancer surgery opens up new opportunities for improving perioperative outcomes and reducing complications.
Prospección arqueológica en el sector oriental de la Depresión de Colmenar
Authors: Baldomero Navarro Ana , Ferrer Palma José Enrique 
Published: April 2023

Se exponen los resultados conseguidos en una prospección arqueológica, llevada a cabo de fonna metódica en el sector oriental de la Depresión de Colmenar, como parte del proyecto de investigación del Dpto. de Prehistoria de la Universidad de Málaga sobre "El tránsito de la Edad del Cobre a la del Bronce en la vía de Sierra Gorda a la Bahía de Málaga".En prospección intensiva se han localizado ocho emplazamientos correspondientes a la Edad del Cobre, uno de época clásica y otros cuatro de época medieval; mientras que los resultados de la prospección selectiva adicional, hasta conseguir el quadrant definitivo, han añadido a los resultados anteriores cuatro yacimientos más de la Edad del Cobre y uno de época clásica. En el texto se describen tan sólo los referentes a la Edad del Cobre, objetivo del proyecto mencionado.