bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translocation of elements and fractionation of Mg, Cu, Zn, and Cd stable isotopes in a penny bun mushroom (Boletus edulis) from western Czech Republic
Authors: Andronikov Alexandre V. , Andronikova Irina E. , Martinkova Eva , Sebek Ondrej , Stepanova Marketa 
Published: February 2023

Abstract
Boletus edulis mushroom behaved as an accumulating biosystem with respect to Ag, Rb, Zn, and K. The mushroom was not an efficient accumulator of toxic As, Pb, and Cr, but Se and Cd displayed much higher concentrations in the mushroom than in the substrate samples. Other elements were bioexclusive. Different elements had different within-mushroom mobilities. The highest mobilities were displayed by Zn and Ag, and the lowest by Ti. The mushroom’s fruiting body preferentially took up lighter Mg, Cu, and Cd isotopes (Δ26MgFB-soil =  −0.75‰; Δ65CuFB-soil =  −0.96‰; Δ114CdFB-soil =  −0.63‰), and the heavier 66Zn isotope (Δ66ZnFB-soil = 0.92‰). Positive within-mushroom Zn isotope fractionation resulted in accumulation of the heavier 66Zn (Δ66Zncap-stipe = 0.12‰) in the mushroom’s upper parts. Cadmium displayed virtually no within-mushroom isotope fractionation. Different parts of the fruiting body fractionated Mg and Cu isotopes differently. The middle part of the stipe (3–6 cm) was strongly depleted in the heavier 26 Mg with respect to the 0–3 cm (Δ26Mgstipe(3–6)-stipe(0–3) =  −0.73‰) and 6–9 cm (Δ26Mgstipe(6–9)-stipe(3–6) = 0.28‰) sections. The same stipe part was strongly enriched in the heavier 65Cu with respect to the 0–3 cm (Δ65Custipe(3–6)-stipe(0–3) = 0.63‰) and 6–9 cm (Δ65Custipe(6–9)-stipe(3–6) =  −0.42‰) sections. An overall tendency for the upper mushroom’s parts to accumulate heavier isotopes was noted for Mg (Δ26Mgcap-stipe = 0.20‰), Zn (Δ66Zncap-stipe = 0.12‰), and Cd (Δ114Cdcap-stipe = 0.04‰), whereas Cu showed the opposite trend (Δ65Cucap-stipe =  −0.08‰).
Development and validation of combined Ki67 status prediction model for intrahepatic cholangiocarcinoma based on clinicoradiological features and MRI radiomics
Authors: Qian Xianling , Zhou Changwu , Wang Fang , Lu Xin , Zhang Yunfei , Chen Lei , Zeng Mengsu 
Published: February 2023

AbstractPurposeIncidence and mortality of intrahepatic cholangiocarcinoma (ICC) have been increasing over the past few decades, and Ki67 is an adverse prognostic predictor and an attractive therapeutic target for ICC patients. Thus, we aim to develop and validate a combined Ki67 prediction model for ICC patients.Materials and methodsPreoperative contrast-enhanced MR images were collected from 178 patients with postoperative pathologically confirmed ICC, and randomly divided into training and validation cohorts in a ratio of 7:3 (124:54). A time-independent test cohort of 49 ICC patients was used for validation. Independent clinicoradiological features of Ki67 status were determined by multivariate analysis. Optimal radiomics features were selected by least absolute shrinkage and selection operator logistic regression and linear discriminant analysis was used to construct combined models. The prediction efficacy of combined model was assessed by receiver operating characteristics curve, and verified by its calibration, decision and clinical impact curves.ResultsHBV (p = 0.022), arterial rim enhancement (p = 0.006) and enhancement pattern (p = 0.012) are independent clinicoradiological features. The radiomics model achieves good prediction efficacy in the training cohort (AUC = 0.860) and validation cohort (AUC = 0.843). The combined Ki67 prediction model incorporates clinicoradiological and radiomics features, and it yields desirable predictive efficiency in test cohort (AUC = 0.815). Decision curves and clinical impact curves further validate that the combined Ki67 prediction model can achieve net benefits in clinical work.ConclusionThe combined Ki67 model incorporating HBV, arterial rim enhancement, enhancement pattern and radiomics features is a potential biomarker in Ki67 prediction and stratification.
Measuring tree stem diameters and straightness with depth-image computer vision
Authors: Tran Hoang , Woeste Keith , Li Bowen , Verma Akshat , Shao Guofan 
Published: February 2023

AbstractCurrent techniques of forest inventory rely on manual measurements and are slow and labor intensive. Recent developments in computer vision and depth sensing can produce accurate measurement data at significantly reduced time and labor costs. We developed the ForSense system to measure the diameters of trees at various points along the stem as well as stem straightness. Time use, mean absolute error (MAE), and root mean squared error (RMSE) metrics were used to compare the system against manual methods, and to compare the system against itself (reproducibility). Depth-derived diameter measurements of the stems at the heights of 0.3, 1.4, and 2.7 m achieved RMSE of 1.7, 1.5, and 2.7 cm, respectively. The ForSense system produced straightness measurement data that was highly correlated with straightness ratings by trained foresters. The ForSense system was also consistent, achieving sub-centimeter diameter difference with subsequent measures and less than 4% difference in straightness value between runs. This method of forest inventory, which is based on depth-image computer vision, is time efficient compared to manual methods and less computationally and technologically intensive compared to Structure-from-Motion (SFM) photogrammetry and ground-based LiDAR or terrestrial laser scanning (TLS).
Quality of Care Transition During Hospital Discharge, Patient Safety, and Weight Regain After Bariatric Surgery: a Cross-Sectional Study
Authors: Marsall Matthias , Bäuerle Alexander , Hasenberg Till , Schräpler Laura , Robitzsch Anita , Niedergethmann Marco , Teufel Martin , Weigl Matthias 
Published: February 2023

Abstract
Purpose
Bariatric surgery is established as the gold standard in the treatment of severe obesity. However, a significant proportion of patients experience a substantial weight regain afterwards. Previous research focused predominantly on patients’ personal factors. Yet, critical discharge process factors that contribute to patient’s adherence after surgical interventions are rarely examined. This study investigated whether high quality of care transitions in discharge management influences weight regain and the likelihood of experiencing adverse patient safety incidents.

Materials and Methods
A cross-sectional study with 578 patients after bariatric surgery was conducted. Participants answered a standardized assessment on the quality of care transition from hospital to home-, surgery-, and nutrition-related characteristics as well as patient safety incidents.

Results
Significant weight regain was observed 24 months after surgery. The association between time since surgery and weight regain was weaker in patients with high quality of care transitions (B = 2.27, p < .001). Higher quality of care transition was also significantly related to a lower likelihood of unplanned hospital readmissions (OR = 0.67) and fewer medication complications (OR = 0.48) after surgery.

Conclusion
This study sheds first light on the key influence of high quality of care transitions after bariatric surgery. Improvement efforts into effective discharge processes may establish smoother care transitions and help patients to assume responsibility and compliance with behavioral recommendations after surgery. Moreover, adverse patient safety incidents are less frequent after high quality care transitions indicating both high quality of health services for patients and reducing costs for the health care system.

Graphical Abstract
Emerging Therapeutic Targets for Portal Hypertension
Authors: Felli Eric , Nulan Yelidousi , Selicean Sonia , Wang Cong , Gracia-Sancho Jordi , Bosch Jaume 
Published: February 2023

AbstractPurpose of ReviewPortal hypertension is responsible of the main complications of cirrhosis, which carries a high mortality. Recent treatments have improved prognosis, but this is still far from ideal. This paper reviews new potential therapeutic targets unveiled by advances of key pathophysiologic processes.Recent FindingsRecent research highlighted the importance of suppressing etiologic factors and a safe lifestyle and outlined new mechanisms modulating portal pressure. These include intrahepatic abnormalities linked to inflammation, fibrogenesis, vascular occlusion, parenchymal extinction, and angiogenesis; impaired regeneration; increased hepatic vascular tone due to sinusoidal endothelial dysfunction with insufficient NO availability; and paracrine liver cell crosstalk. Moreover, pathways such as the gut-liver axis modulate splanchnic vasodilatation and systemic inflammation, exacerbate liver fibrosis, and are being targeted by therapy. We have summarized studies of new agents addressing these targets.SummaryNew agents, alone or in combination, allow acting in complementary mechanisms offering a more profound effect on portal hypertension while simultaneously limiting disease progression and favoring regression of fibrosis and of cirrhosis. Major changes in treatment paradigms are anticipated.
Deep learning in sex estimation from a peripheral quantitative computed tomography scan of the fourth lumbar vertebra—a proof-of-concept study
Authors: Oura Petteri , Korpinen Niina , Machnicki Allison L. , Junno Juho-Antti 
Published: February 2023

Abstract
Sex estimation is a key element in the analysis of unknown skeletal remains. The vertebrae display clear sex discrepancy and have proven accurate in conventional morphometric sex estimation. This proof-of-concept study aimed to investigate the possibility to develop a deep learning algorithm for sex estimation even from a single peripheral quantitative computed tomography (pQCT) slice of the fourth lumbar vertebra (L4). The study utilized a total of 117 vertebrae from the Terry Anatomical Collection. There were 58 male and 59 female cadavers, all of the white ethnicity, with the average age at death 49 years and a range of 24 to 77 years. A coronal pQCT scan was taken from the midway of the L4 corpus. Sex estimation was performed in a total of 19 neural network architectures implemented in the AIDeveloper software. Of the explored architectures, a LeNet5-based algorithm reached the highest accuracy of 86.4% in the test set. Sex-specific classification rates were 90.9% among males and 81.8% among females. This preliminary finding advances the field by encouraging and directing future research on artificial intelligence-based methods in sex estimation from individual skeletal traits such as the vertebrae. Combining quickly obtained imaging data with automated deep learning algorithms may establish a valuable pipeline for forensic anthropology and provide aid when combined with traditional methods.
An Eco-Friendly and Hopeful Promise Platform for Delivering Hydrophilic Wound Healing Agents in Topical Administration for Wound Disorder: Diltiazem-Loaded Niosomes
Authors: Akbari Jafar , Saeedi Majid , Morteza-Semnani Katayoun , Ghasemi Maryam , Eshaghi Malihe , Eghbali Mohammad , Jafarkhani Behrouz , Rahimnia Seyyed Mobin , Negarandeh Reza , Babaei Amirhossein , Hashemi Seyyed Mohammad Hassan , Asare-Addo Kofi , Nokhodchi Ali 
Published: February 2023

Abstract

Purposes
Calcium channel blockers, such as diltiazem (DLZ), are important drugs for wound repair treatment. This current study used an ultrasonic method to increase the cutaneous delivery of (DLZ) niosomes.

Methods
The impact of the cholesterol:surfactant ratio on the DLZ-loaded niosome formulations was investigated. Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, drug release, skin sensitivity, animal wound repair model, and histopathological assessment were applied to investigate the characteristics, morphology, and therapeutic effectiveness of the DLZ noisome.

Results
The results showed that changes in the cholesterol:surfactant ratio can influence the zeta potential and the size of the niosome. The maximum entrapment efficiency was observed to be about 94% when the cholesterol content in the formulation was high. The DLZ release studies revealed that the niosomal formulation was released slowly over the course of 24 h. Macroscopic observations of the wound demonstrated that wound closure in the DLZ-niosome-treated group and the commercial brand was equal and higher than in the other groups (gel base, placebo gel, and negative control). Pathological studies described that the wound repair in the DLZ-niosomal gel group was greater than in the other treatment. All the preparations tested for cutaneous irritation on Wistar rats showed the DLZ niosomal gels to be non-irritating.

Conclusion
The findings of this study revealed that the prepared DLZ-niosome could be used as a possible nano-vesicle for DLZ cutaneous delivery thus potentially opening up new prospects for the treatment of wound disorders.
Activation of Cannabinoid Receptor 1 in GABAergic Neurons in the Rostral Anterior Insular Cortex Contributes to the Analgesia Following Common Peroneal Nerve Ligation
Authors: Zhang Ming , Li Cong , Xue Qian , Lu Chang-Bo , Zhao Huan , Meng Fan-Cheng , Zhang Ying , Wu Sheng-Xi , Zhang Yan , Xu Hui 
Published: February 2023

AbstractThe rostral agranular insular cortex (RAIC) has been associated with pain modulation. Although the endogenous cannabinoid system (eCB) has been shown to regulate chronic pain, the roles of eCBs in the RAIC remain elusive under the neuropathic pain state. Neuropathic pain was induced in C57BL/6 mice by common peroneal nerve (CPN) ligation. The roles of the eCB were tested in the RAIC of ligated CPN C57BL/6J mice, glutamatergic, or GABAergic neuron cannabinoid receptor 1 (CB1R) knockdown mice with the whole-cell patch-clamp and pain behavioral methods. The E/I ratio (amplitude ratio between mEPSCs and mIPSCs) was significantly increased in layer V pyramidal neurons of the RAIC in CPN-ligated mice. Depolarization-induced suppression of inhibition but not depolarization-induced suppression of excitation in RAIC layer V pyramidal neurons were significantly increased in CPN-ligated mice. The analgesic effect of ACEA (a CB1R agonist) was alleviated along with bilateral dorsolateral funiculus lesions, with the administration of AM251 (a CB1R antagonist), and in CB1R knockdown mice in GABAergic neurons, but not glutamatergic neurons of the RAIC. Our results suggest that CB1R activation reinforces the function of the descending pain inhibitory pathway via reducing the inhibition of glutamatergic layer V neurons by GABAergic neurons in the RAIC to induce an analgesic effect in neuropathic pain.
Neutron activation analysis in Mediterranean Archaeology: current applications and future perspectives
Authors: Riehle Kai , Kistler Erich , Öhlinger Birgit , Heitz Christian , Ben-Shlomo David , Jung Reinhard , Mommsen Hans , Sterba Johannes H. , Gimatzidis Stefanos , Fantalkin Alexander , Prillwitz Susanne , Hein Anno , Geissler Leonhard , Lehmann Gunnar , Kindberg Jacobsen Jan , Posamentir Richard , Schlotzhauer Udo 
Published: February 2023

AbstractThis paper, jointly written by participants of a workshop held in 2021, argues for an increased recognition and application of neutron activation analysis (NAA) in the archaeology of the ancient Mediterranean. Discussing the methodological strengths and challenges, it highlights the great potential NAA has for collecting proxy data from ceramics in order to develop progressive concepts of archaeological research within and beyond the Mediterranean Bronze and Iron Age, pointing out opportunities to revisit long-held assumptions of scholarship and to refine visual/macroscopic provenance determinations of pottery. To take full advantage of NAA’s strengths toward a better understanding of the socioeconomic background of ceramics production, distribution, and consumption, the paper emphasises the need for both interdisciplinary collaboration and basic data publication requirements.
Study on the Influence of Nickel Additions on AA7020 Formability Under Superplastic Forming Like Conditions
Authors: Taylor S. , Janik V. , Grimes R. , Dashwood R. 
Published: February 2023

Abstract
This study set out to look at the influence of nickel additions on a commercially available AA7020 to understand the impact of the resultant intermetallics on recrystallization, formability and material strength. Elevated temperature tensile testing across a range of strain rates (5 × 10−4 s−1 × 10−1 s−1) and three temperatures (450− 500 °C) to compare material ductility followed by gas bulge testing at 475 °C and two gas pressures to investigate formability in a test closer to industrial forming conditions. Material strength was established using standard tensile testing, and EBSD used to understand the microstructural evolution of the materials. It was seen that the nickel additions increased ductility of the material across all test conditions, coupled with increasing the material strength. This was achieved due to the formation of nickel rich intermetallics which refine the microstructure during pre-heating through particle stimulated nucleation and subsequently improve strength through precipitation hardening in aging treatments.

Graphic Abstract
Three-dimensional mouse cochlea imaging based on the modified Sca/eS using confocal microscopy
Authors: Urata Shinji , Okabe Shigeo 
Published: February 2023

AbstractThe three-dimensional stria vascularis (SV) and cochlear blood vessel structure is essential for inner ear function. Here, modified Sca/eS, a sorbitol-based optical-clearing method, was reported to visualize SV and vascular structure in the intact mouse cochlea. Cochlear macrophages as well as perivascular-resident macrophage-like melanocytes were detected as GFP-positive cells of the CX3CR1+/GFP mice. This study’s method was effective in elucidating inner ear function under both physiological and pathological conditions.
The politics of national SDG indicator systems: A comparison of four European countries
Authors: Lepenies Robert , Büttner Leonie , Bärlund Ilona , Jax Kurt , Lyytimäki Jari , Pedersen Anders Branth , Nielsen Helle Ørsted , Mosoni Claire , Mille Raoul , Payen Gerard , Richard Didier 
Published: February 2023

AbstractThe sustainable development goals (SDGs) constitute an ambitious comprehensive global framework including monitoring mechanisms and indicators to evaluate progress towards precise targets of sustainable development. Most European countries have adapted their national sustainability indicator systems to conform to the UN Agenda 2030 for sustainable development, introducing new indicators and monitoring frameworks and governance processes in which these are embedded. What do we know about the political processes and struggles of implementing this important global framework? How does the politics of indicators differ in national contexts? We propose a classification of national indicator systems along dimensions of indicator selection, appraisal landscape, participatory nature, and political communication. We empirically explore these dimensions for four European national sustainability indicator systems through a comparative analysis based on national policy documents, indicator databases, and web portals as well as inputs from workshops and expert interviews. Given the considerable variation with respect to the trajectory of national sustainability indicator systems, we posit that these differences correspond to different national interpretations of sustainability.
Reforming a pre-existing biodiversity conservation scheme: Promoting climate co-benefits by a carbon payment
Authors: Kangas Johanna , Ollikainen Markku 
Published: February 2023

AbstractProtecting forests provides potential synergies for both biodiversity conservation and climate change mitigation. Payments for ecosystem services (PES) schemes are commonly used to promote biodiversity conservation in private forests, and including carbon as another target may be a cost-efficient way to promote both goals. We analyse a hypothetical reform on a forest biodiversity PES scheme by supplementing it with a carbon payment paid to landowners for also providing carbon benefits. With a site selection model, we examine how the proposed scheme could promote biodiversity and carbon values, and what level of the carbon payment would provide the highest synergy gains. We found that introducing the payment promotes both targets, but there is a temporal trade-off between selecting sites with high carbon storage or sites with good sequestration potential. The highest synergy gains are obtained in most cases by a second-best payment level of 10–20 € tCO2−1.
The difficulty grade of laparoscopic hepatectomy for hepatocellular carcinoma correlates with long-term outcomes
Authors: Lv Xiaocui , Zhang Lina , Yu Xin , Yu Hong 
Published: February 2023

AbstractThe tremendous development of laparoscopic hepatectomy helps to relieve the difficulties encountered during open hepatectomy. Therefore, a difficulty scoring system was produced to assess the difficulty grade of laparoscopic hepatectomy. The aim of this study was to explore whether the IWATE-DSS is comparable to the long-term outcomes of LH for hepatocellular carcinoma. Clinical data from all consecutive patients who underwent laparoscopic hepatectomy for hepatocellular carcinoma at the Sir Run Run Shaw Hospital, Hangzhou, were prospectively collected and reviewed. The difficulty level of the operations was graded using the IWATE-DSS. The perioperative and postoperative outcomes of laparoscopic hepatectomy were compared at each difficulty level. A total of 300 patients underwent laparoscopic hepatectomy for HCC during the study period. The perioperative and postoperative outcomes were significantly different between the groups according to the IWATE-DSS. There were significant differences in both the intraoperative (bleeding control p = 0.000; surgical time p = 0.000; estimated blood loss p = 0.033) and postoperative variables (postoperative hospital stay p = 0.005) among these four groups. The 5-year disease-free survival decreased significantly along with the LH difficulty score (p = 0.000). The 5-year overall survival also decreased significantly along with the LH difficulty score (p = 0.000). IWATE-DSS was significantly correlated with short- and long-term outcomes in patients who underwent laparoscopic hepatectomy for HCC.
Rapid-progressing progressive multifocal leukoencephalopathy in two patients newly diagnosed with HIV: case series and review of literature
Authors: Badura Barbara , Barczak Szymon , Mikuła Tomasz , Wiercińska-Drapało Alicja 
Published: February 2023

AbstractThe JC Polyomavirus (JCPyV) is a virus of global distribution and is usually kept under control by the immune system. In patients with AIDS, a latent JCPyV infection can reactivate and develop into progressive multifocal leukoencephalopathy (PML). Around half of the patients with PML die within 2 years since the diagnosis, yet in rare cases, the disease advances significantly quicker and seems to be insusceptible to any medical actions. In our clinic, we observed two cases of such course in HIV-positive patients in the AIDS stage. On admission, both patients had mild neurological symptoms such as dizziness, vision disturbances, and muscle weakness. Both had extremely low CD4 lymphocyte count (7 cells/μL, 40 cells/μL) and high HIV-1 viral load (VL) (50,324 copies/ml, 78,334 copies/ml). PML was confirmed by PCR for JCPyV DNA in cerebrospinal fluid (CSF) coupled with clinical and radiological features. Despite receiving though antiretroviral (ARV) treatment paired with intra-venous (IV) steroids, the disease progressed rapidly with neurological manifestations exacerbating throughout the few weeks following the admission. Eventually, both patients developed respiratory failure and died within less than 3 months after the onset of the neurological symptoms. Even though such curse of the disease is not common, it should be a warning to all how deadly both PML and AIDS can be and remind doctors to offer testing even to asymptomatic patients.