bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of joint orientation on passive movement of the dog’s stifle
Authors: Yair Nadav , Yiapanis Christos , Ben-Amotz Ron , Milgram Joshua 
Published: June 2023

IntroductionThe cranial cruciate ligament (CCL) is one of numerous structures which determine the path of the tibia relative to the femur when passively flexing/extending the stifle of the dog. The effect of cutting the CCL on passive motion with the hind limb in different orientations, is unknown. The aim of this study was to describe passive movement of the tibia relative to the femur in dogs, with the hind limb in three different orientations, and with CCL intact and cut.MethodsTen cadaveric hind limbs were obtained from dogs weighing between 20 kg and 25 kg and prepared for testing in a custom-built joint testing machine. Each hind limb was tested in three different orientations with data collected, using an electromagnetic tracking system, during 2 cycles of flexion/extension with the CCL intact and cut. Each cycle was initiated with the stifle in full extension (0°) and data was collected at 0°, 20°, 30°, 40°, 45°, and 55° of stifle flexion/extension.ResultsFlexion of the stifle resulted in caudal translation and internal rotation of the tibia relative to the femur, with cranial translation and external rotation occurring during extension along the identical path. Cutting the cranial cruciate ligament did not result in significant differences in translation or rotation when the stifle was orientated to approximated the standing position of a dog.DiscussionIsometric points at the origin and insertion of the CCL can potentially be identified in CCL deficient stifles using a technique based on passive motion of an intact stifle.
Imlifidase for Kidney Transplantation of Highly Sensitized Patients With a Positive Crossmatch: The French Consensus Guidelines
Authors: Couzi Lionel , Malvezzi Paolo , Amrouche Lucile , Anglicheau Dany , Blancho Gilles , Caillard Sophie , Freist Marine , Guidicelli Gwenda Line , Kamar Nassim , Lefaucheur Carmen , Mariat Christophe , Koenig Alice , Noble Johan , Thaunat Olivier , Thierry Antoine , Taupin Jean-Luc , Bertrand Dominique 
Published: June 2023

Imlifidase recently received early access authorization for highly sensitized adult kidney transplant candidates with a positive crossmatch against an ABO-compatible deceased donor. These French consensus guidelines have been generated by an expert working group, in order to homogenize patient selection, associated treatments and follow-up. This initiative is part of an international effort to analyze properly the benefits and tolerance of this new costly treatment in real-life. Eligible patients must meet the following screening criteria: cPRA ≥ 98%, ≤ 65-year of age, ≥ 3 years on the waiting list, and a low risk of biopsy-related complications. The final decision to use Imlifidase will be based on the two following criteria. First, the results of a virtual crossmatch on recent serum, which shall show a MFI for the immunodominant donor-specific antibodies (DSA) &gt; 6,000 but the value of which does not exceed 5,000 after 1:10 dilution. Second, the post-Imlifidase complement-dependent cytotoxicity crossmatch must be negative. Patients treated with Imlifidase will receive an immunosuppressive regimen based on steroids, rATG, high dose IVIg, rituximab, tacrolimus and mycophenolic acid. Frequent post-transplant testing for DSA and systematic surveillance kidney biopsies are highly recommended to monitor post-transplant DSA rebound and subclinical rejection.
Kaempferol and Biomodified Kaempferol from Sophora japonica Extract as Potential Sources of Anti-Cancer Polyphenolics against High Grade Glioma Cell Lines
Authors: dos Santos Jéssica Silva , Suzan Amanda Janaína , Bonafé Gabriel Alves , Fernandes Anna Maria Alves de Piloto , Longato Giovanna Barbarini , Antônio Márcia Aparecida , Carvalho Patrícia de Oliveira , Ortega Manoela Marques 
Published: June 2023

The enzymatic hydrolysis of the extract of Sophora japonica by two glycosyl hydrolases (hesperidinase and galactosidase) was performed in order to obtain kaempferol (KPF)-enriched extract with an enhanced anticancer activity. The current study examined the effectiveness of both Sophora japonica extracts (before (KPF-BBR) and after (KPF-ABR) bioconversion reactions) in reducing cell viability and inducing apoptosis in human high-degree gliomas in vitro. Cytotoxicity was determined using an MTT assay. The effects of both compounds on the proliferation of glioma cell lines were measured using trypan blue exclusion, flow cytometry for cell cycle, wound healing (WH), and neurosphere formation assays. Cellular apoptosis was detected by DNA fragmentation and phosphatidylserine exposure. qPCR and luciferase assays evaluated NF-kB pathway inhibition. The survival rate of NG-97 and U-251 cells significantly decreased in a time- and dose-dependent manner after the addition of KPF-BBR or KPF-ABR. Thus, a 50% reduction was observed in NG-97 cells at 800 µM (KPF-BBR) and 600 µM (KPF-ABR) after 72 h. Both compounds presented an IC50 of 1800 µM for U251 after 72 h. The above IC50 values were used in all of the following analyses. Neither of the KPF presented significant inhibitory effects on the non-tumoral cells (HDFa). However, after 24 h, both extracts (KPF-BBR and KPF-ABR) significantly inhibited the migration and proliferation of NG-97 and U-251 cells. In addition, MMP-9 was downregulated in glioma cells stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) plus KPF-BBR and TPA+KPF-ABR compared with the TPA-treated cells. Both KPF-BBR and KPF-ABR significantly inhibited the proliferation of glioma stem cells (neurospheres) after 24 h. DNA fragmentation assays demonstrated that the apoptotic ratio of KPF-ABR-treated cell lines was significantly higher than in the control groups, especially NG-97, which is not TMZ resistant. In fact, the flow cytometric analysis indicated that KPF-BBR and KPF-ABR induced significant apoptosis in both glioma cells. In addition, both KPF induced S and G2/M cell cycle arrest in the U251 cells. The qPCR and luciferase assays showed that both KPFs downregulated TRAF6, IRAK2, IL-1β, and TNF-α, indicating an inhibitory effect on the NF-kB pathway. Our findings suggest that both KPF-BBR and KPF-ABR can confer anti-tumoral effects on human cell glioma cells by inhibiting proliferation and inducing apoptosis, which is related to the NF-κB-mediated pathway. The KPF-enriched extract (KPF-ABR) showed an increased inhibitory effect on the cell migration and invasion, characterizing it as the best antitumor candidate.
Une abasileusia durant l’an 3 de Cléopâtre VII
Authors: Legras Bernard 
Published: June 2023

Un papyrus publié en 2014 (BGU XX 2847) mentionne une situation d’ ἀβασiλευσία.
Cette «absence de roi» s’inscrit dans un contexte troublé de lutte pour le pouvoir entre Ptolémée XIII et Cléopâtre VII. Durant la guerre civile de l’été 49, Ptolémée XIII aurait tenu la Basse-Égypte et Cléopâtre la Haute-Égypte, tandis que la Moyenne-Égypte, d’où provient le papyrus, aurait été âprement disputée.
PENGARUH LEVERAGE, PROFITABILITAS, UKURAN PERUSAHAAN DAN KEPEMILIKAN TERKONSENTRASI TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN PROPERTY DAN REAL ESTATE DI BURSA EFEK INDONESIA PERIODE 2016 – 2020
Authors: Kristofel  , Van Rate Paulina , Loindong Sjendry S.R. 
Published: June 2023

Penelitian ini bertujuan untuk mengukur pengaruh leverage, profitabilitas, ukuran Perusahaan, kepemilikan terkonsentrasi terhadap nilai perusahaan pada perusahaan property dan real estate di Bursa Efek Indonesia. Jenis penelitian yang digunakan adalah penelitian kuantitatif. Perusahaan property dan real estate yang terdaftar di Bursa Efek Indonesia sebanyak 59 perusahaan. Sampel yang digunakan adalah 6 perusahaan. Teknik analisis data menggunakan regresi linear berganda dengan bantuan aplikasi SPSS 20. Hasil penelitian menunjukkan bahwa secara parsial Leverage berpengaruh negatif terhadap nilai perusahaan, profitabilitas dan kepemilikan terkonsentrasi berpengaruh terhadap nilai perusahaan, sedangkan ukuran perusahaan tidak berpengaruh terhadap nilai perusahaan. Dan secara simultan leverage, profitabilitas, ukuran perusahaan, dan kepemilikan terkonsentrasi berpengaruh terhadap nilai perusahaan.

Kata Kunci: leverage, profitabilitas, ukuran perusahaan, kepemilikan terkonsentrasi, nilai perusahaan
Analisis Penetrasi Pasar dan Pengembangan Pasar terhadap retensi Pelanggan oleh Petani Cabe Keriting di Kelurahan Kakaskasen I dan Kakaskasen II Kecamatan Tomohon Utara Kota Tomohon Propinsi Sulawesi Utara
Authors: Rorah Ignatius R. C , Poluan Margie , Paath Franki , Wongkar Meitty 
Published: June 2023

Retensi pelanggan dianggap sebagai tujuan yang sangat penting dan komponen kompetitifdalam lingkungan bisnis apa pun saat ini. Penetresi pasar dan Pengembangan pasar merupakan salah satu aspek penting dalam kegiatan bisnis. Pasar memiliki nilai strategis sebagai tempat bertemunya penjual dan pembeli .Tujuan penelitian ini untuk mengkaji dan menganalisis penerapan penetrasi pasar dan pengembangan pasar para petani cabe keriting di kelurahan Kakaskasen I dan Kakaskasen II kecamatan Tomohon Utara Kota Manado. metode penelitian yang digunakan pada penelitian ini adalah metode kualitatif dengan sumber data yang diperoleh dari observasi dan hasil wawancara secara mendalam dengan berbagai narasumber. Hasil peneltian menunjukkan Penerapan Market Penetration dalam pelaksanaan proses pemasaran cabe keriting sudah baik dalm penerapan metode penetrasi pasar dengan memberikan waktu dan kesempatan kepada pelanggan untuk melakukan pembelian langsung di kebun, namun konsistensi kesepakatan seringkali di abaikan ini akan berpengaruh terhadap retensi pelanggan utnuk tetap setia dengan produk para petani .

Penerapan Market development Pendekatan khusus untuk konsentrasi pertumbuhan pengembangan pasar, dengan 4 elemen : Konsentrasi, menarik pelanggan pesaing,menarik bukan pelanggan untuk membeli dan pengembangan pasar sudah berjalan dengan baik,sehingga retensi pelanggan tetap terjaga.

Kata Kunci: Penetrasi Pasar, Pengembangan Pasar , Retensi Pelanggan
Study on measurement capability of probe-backside reflection method for evaluation of dielectric materials
Authors: Sakamaki Ryo 
Published: June 2023

Abstract
This study clarifies the measurement capability of the probe-backside reflection (PBR) method for the evaluation of dielectric materials. Because the PBR method requires the preparation of a coplanar waveguide (CPW) on a material-under-test (MUT), the measurement capability is limited not only by the dielectric properties of the MUT but also by the limitations in the CPW design. In this study, the measurement capability of the PBR method was estimated to be limited up to 15 for the dielectric permittivity, and from 3 × 10−3 to 2 × 10−1 for the dielectric loss tangent, in the frequency range up to 300 GHz.
PENERAPAN METODE OUTDOOR LEARNING UNTUK MENINGKATKAN MOTIVASI BELAJAR DI RA
Authors: ' Hartik , Novitasari Nurul , Rahman Tatang Aulia 
Published: June 2023

Abstrak
Penelitian ini menjelaskan tentang penerapan metode outdoor learning untuk meningkatkan motivasi belajar siswa RA Al Irsyad pada tahun pelajaran 2022/2023. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Metode pengumpulan data yang digunakan adalah wawancara, observasi dan dokumentasi. Hasil dari penelitian ini menunjukkan bahwa setelah diterapkannya metode outdoor learning motivasi belajar siswa meningkat dari 19 siswa hanya ada 2 siswa yang Mulai Berkembang (MB), sedangkan 7 siswa Berkembang Sesuai Harapan (BSH) dan 9 siswa Berkembang dengan Baik (BSB). Dari hasil tersebut dapat dikatakan metode outdoor learning mampu meningkatkan motivasi belajar siswa RA Al Irsyad Jatirogo tahun pelajaran 2022/2023. Faktor pendukung pada penelitian ini adalah media pembelajaran mudah didapat dan tidak mahal, kegiatan belajar lebih bebas dan menyenangkan, media belajar konkrit dan siswa lebih aktif. Sedangkan faktor penghambatnya adalah kurangnya konsentrasi, memakan banyak waktu apabila lokasi belajar jauh, dan cuaca panas dingin serta polusi udara yang menyebabkan siswa mudah terserang penyakit.
Kata Kunci: motivasi belajar, outdoor learning, metode pembelajaran.

Abstract
This study describes the application of the outdoor learning method to increase the learning motivation of RA Al Ersyad students in the 2022/2023 school year. This research use desciptive qualitative approach. Data collection methods used are interviews, observation and documentation. The results of this study indicate that after the application of the outdoor learning method, student learning motivation increased from 19 students, only 2 students started to develop (MB), while 7 students developed according to expectations (BSH) and 9 students developed well (BSB). From these results it can be said that the outdoor learning method is able to increase the learning motivation of RA Al Irsyad Jatirogo students for the 2022/2023 academic year. Supporting factors in this study are learning media that are easy to obtain and inexpensive, learning activities are more free and enjoyable, learning media are concrete and students are more active. While the inhibiting factors are lack of concentration, it takes a lot of time if the study location is far away, and hot and cold weather and air pollution make students susceptible to disease.
Keywords: motivation to learn, outdoor learning, learning methods
Cardiac Rehabilitation in Patients with Pacemakers Implantation
Authors: Tedjasukmana Deddy , Ni Luh Made Murniasih Jayanthi  
Published: June 2023

Total AV block is a condition when the impulses from the atrium cannot reach the ventricles. Indications for the implantation of a permanent pacemaker are symptomatic bradycardia and high-risk conditions such as total AV block. The following case discusses a patient with total AV block post implantation of permanent pacemaker (PPM). Cardiac rehabilitation program started when the patient is hemodynamically stable. In bed exercises are carried out to prevent bed rest complications such as joint range of motion exercises and breathing exercises. After the patient underwent PPM insertion, the first phase of cardiac rehabilitation with mobilization program started 24 hours after implantation. More intensive mobilization was carried out and a six-minute walking test was carried out before discharge. In the next phase, a second phase of cardiac rehabilitation (outpatient) is carried out for 4-8 weeks considering the healing time after implantation after 1 weeks.
The Effect of Additional of Aerobic Exercise to Functional Therapy on Resting Heart Rate in Patients with Chronic Phase Post Stroke
Authors: Yunus Fanny Thresia , Hari Peni Julianti  , Erna Setiawati  
Published: June 2023

Introduction: Regular aerobic exercise has a direct effect on resting heart rate, both acute and chronic effects. One of the chronic effects decrease resting heart rate which is beneficial for heart health. The objective of this study was to prove the effect of adding aerobic exercise to functional therapy on resting heart in post-stroke patients with chronic phase.
Methods: The study used a randomized controlled trial with pre and post-test control group design. The treatment group (n = 10) received additional aerobic exercise and the control group only received functional therapy (n = 10). Assessment of resting heart rate measurements was carried out before and after exercise.
Results: There was a significant difference (p=<0.001) in the mean resting heart rate in the treatment group before intervention 89.00 ± 9.13 and after intervention 76.10 ± 10.16. There was a significant difference (p=0.017) in the mean resting heart rate in the control group before intervention 88.60 ± 7.75 and after intervention 84.40 ± 6.98. There was a significant difference in the resting heart rate delta value between the treatment group (-12.90 ± 6.56) compared to the control group (-4.20 ± 4.37).
Discussion: The value of resting heart rate pre and post-test in the treatment group showed a more significant difference than the control group. Aerobic exercise can inhibit the activation of the sympathetic nervous system and increase the activation of the parasympathetic nervous system due to the effects of cardiovascular adaptation
Conclusion: The intervention of adding aerobic exercise can reduce resting heart rate in post-stroke patients with chronic phase.
Keywords: Aerobic exercise, functional therapy
Editorial
Authors: Menna Barreto Ricardo 
Published: June 2023

“O pensamento humano é rematadamente social: social em sua origem, em suas funções, social em suas formas, social em suas aplicações. Fundamentalmente, é uma atividade pública” 1. Infundida pelas palavras de Clifford Geertz, Campo Jurídico abre, orgulhosamente, mais uma edição, possibilitando e reforçando este elo social do pensamento humano.
Fundamentos para una “Teoría Pura del Derecho agrario” contemporáneo
Authors: Zeledón Ricardo Zeledón 
Published: June 2023

Premisa: frente a los problemas de desconocimiento del nuevo agrarista en relación con los argumentos fundamentales de la Misión de la disciplina es necesario impulsar una “Teoría pura del Derecho agrario” contemporáneo. 2. El Derecho agrario es cultura, es y se está haciendo. Es un Derecho que produce Derecho y sobre este aún más Derecho, en razón de las exigencias de la Sociedad contemporánea. 3. En una “Teoría pura del Derecho agrario” se impone dominar su historia: su origen, formación y desarrollo. Diferentes acepciones de lo agrario. Diferencia entre Derecho agrario como sistema jurídico y como Ciencia. 4. Obligación metodológica de conocer el debate histórico sobre autonomía y especialidad, entre las Escuelas Clásicas de la disciplina, de Giangastone Bolla y Ageo Arcangeli. 5. Exigencia metodológica de identificar la Escuela Moderna del Derecho agrario de Antonio Carrozza, como etapa superior de las escuelas clásicas, y sus aportes metodológicos y científicos: desde los institutos, la agrariedad, el objeto y el método. 6. La Escuela Moderna del Derecho agrario logra superar una serie de problemas, como el de la autonomía y la especialidad, a través de la respuesta metodológica del estudio por institutos y la superación de los principios generales. 7. La noción del ciclo biológico o de la agrariedad como símbolo de la teoría general del Derecho agrario. 8. El problema del objeto y el método como inicio a una labor científica. 9. El Derecho agrario AAA (de la agricultura, la alimentación y el ambiente), como etapa intermedia o de tránsito, plagada de errores y equivocaciones jurídicas especialmente con la intromisión de los conceptos de lo agroambiental y agroalimentario. Búsqueda del contenido verdadero. 10. El surgimiento del Derecho agrario contemporáneo, como etapa de síntesis y proyección de las Escuelas agraristas. Diferencias de fondo y similitudes de forma y objetivos con la “Teoría pura del Derecho” de Hans Kelsen. El Tridimensionalismo epistemológico: del tratamiento del objeto, el método, las fuentes y la interpretación como fundamentos para una “Teoría pura del Derecho agrario”. El tema del contenido. La interpretación jurídica como parte de la “Teoría pura del Derecho agrario”.
Motivación intrínseca e implicación de estudiantes de bachillerado de una unidad educativa pública
Authors: Rosado Chichande Karen Andrea , Chichande Anzules Yalila Marlene 
Published: June 2023

El propósito de la presente investigación es indentificar la motivación intrínseca que tienen los estudiantes de bachillerato general unificado por medio de la implicación que presentan por género y edad. La problemática que aborda el estudio se centra en el gran índice de estudiantes que poseen poca motivación intrínseca por aprender, ocasionando que no se esfuercen por las actividades de aprendizaje. La metodología se basó en el enfoque cuantitativo, con un diseño no experimental trasversal. La población se conformó de 2184 estudiantes pertenecientes a la institución y la muestra fue de 70 estudiantes de bachillerato. El instrumento que se utilizó es la encuesta estandarizada para determinar el grado de motivación intrínseca. El análisis de datos se basa en la estadística descriptiva por medio del programa SPSS para sistematizar los datos. En los resultados se determinó que existe una adecuada motivación intrínseca e implicación educativa, sin embargo, esto no implica un proceso concluido, ya que se puede continuar mejorando. En las conclusiones se proponen que las variables estudiadas son relevantes para el desarrollo integral de los estudiantes, por otro lado, en las recomendaciones se focaliza la atención en la necesidad de aplicacar estrategias para motivar el aprendizaje en las clases.
Interstellar Polarization Survey. III. Relation between Optical Polarization and Reddening in the General Interstellar Medium
Authors: Angarita Y. , Versteeg M. J. F. , Haverkorn M. , Rodrigues C. V. , Magalhães A. M. , Santos-Lima R. , Kawabata Koji S. 
Published: June 2023

Abstract
Optical starlight can be partially polarized while propagating through the dusty, magnetized interstellar medium (ISM). The polarization efficiency describes the polarization intensity fraction per reddening unit, P

V
/E(B − V), related to the interstellar dust grains and magnetic field properties. The maximum value observed, [P

V
/E(B − V)]max, is thus achieved under optimal polarizing conditions of the ISM. Therefore, the analysis of polarization efficiency observations across the Galaxy contributes to the study of magnetic field topology, small-scale magnetic fluctuations, grain-alignment efficiency, and composition. Infrared observations from Planck satellite have set [P

V
/E(B − V)]max to 13% mag−1. However, recent optical polarization observations in Planck's highly polarized regions showed polarization efficiency values between 13.6% mag−1 and 18.2% mag−1 (depending on the extinction map used), indicating that [P

V
/E(B − V)]max is not well constrained yet. We used V-band polarimetry of the Interstellar Polarization Survey (consisting of ∼10,500 high-quality observations distributed in 34 fields of 0.°3 × 0.°3) to accurately estimate the polarization efficiency in the ISM. We estimated the upper limit of P

V
/E(B − V) with the weighted 99th percentile of the field. In five regions, the polarization efficiency upper limit is above 13% mag−1. Furthermore, we found [P

V
/E(B − V)]

max

=

15.8

−
0.9

+
1.3

% mag−1 using diffuse intermediate-latitude (∣b∣ > 7.°5) regions with apparently strong regular Galactic magnetic field in the plane-of-sky. We studied the variations of P

V
/E(B − V) across the sky and tested toy models of polarization efficiency with Galactic longitude that showed some correspondence with a uniform spiral magnetic field.
État de l’éducation, de la recherche et des pratiques professionnelles reliées à la veille au Canada et aux États-Unis
Authors: Bouthillier France 
Published: June 2023

L’article offre une revue narrative de la littérature sur la veille concurrentielle et stratégique principalement et, dans une moindre mesure, sur l’intelligence économique et la veille informationnelle, pour explorer l’état de la formation académique, de la recherche académique et des pratiques professionnelles au Canada et aux États-Unis. Les écrits sélectionnés et publiés entre 2000 et 2021 retracent les principaux éléments marquant l’évolution des programmes d’études, des sujets de recherche et des intérêts professionnels reliés à la veille.