bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance Analysis of the Multi-connection Tactile Internet Protocol over 5G
Authors: Rico Delia , Grinemmo Karl-Johan , Brunstrom Anna , Merino Pedro 
Published: June 2023

AbstractTactile Internet is an Internet network that combines ultra-low latency with extremely high availability and reliability. Since traditional protocols, such as UDP and TCP, cannot support this operation, other transport protocols are required to meet the stringent requirements of the Tactile Internet. This paper evaluates the implementation of the Multi-connection Tactile Internet Protocol (MTIP), a multi-connectivity transport protocol for the Tactile Internet. MTIP uses application and network status information to select network paths intelligently and, in so doing, to improve reliability and latency. The paper studies how different configurations of the MTIP algorithm impact its path selection and the effect on lost and late packets. This evaluation is performed in an emulated environment and in a 4G/5G lab to evaluate the protocol in diverse scenarios. The results show a direct trade-off between higher reliability requirements and the number of duplicate packets.
Molecular insights into titin’s A-band
Authors: Fleming Jennifer R. , Müller Iljas , Zacharchenko Thomas , Diederichs Kay , Mayans Olga 
Published: May 2023

AbstractThe thick filament-associated A-band region of titin is a highly repetitive component of the titin chain with important scaffolding properties that support thick filament assembly. It also has a demonstrated link to human disease. Despite its functional significance, it remains a largely uncharacterized part of the titin protein. Here, we have performed an analysis of sequence and structure conservation of A-band titin, with emphasis on poly-FnIII tandem components. Specifically, we have applied multi-dimensional sequence pairwise similarity analysis to FnIII domains and complemented this with the crystallographic elucidation of the 3D-structure of the FnIII-triplet A84-A86 from the fourth long super-repeat in the C-zone (C4). Structural models serve here as templates to map sequence conservation onto super-repeat C4, which we show is a prototypical representative of titin’s C-zone. This templating identifies positionally conserved residue clusters in C super-repeats with the potential of mediating interactions to thick-filament components. Conservation localizes to two super-repeat positions: Ig domains in position 1 and FnIII domains in position 7. The analysis also allows conclusions to be drawn on the conserved architecture of titin’s A-band, as well as revisiting and expanding the evolutionary model of titin’s A-band.
Long-read Sequencing and de novo Genome Assembly of Three Aspergillus fumigatus Genomes
Authors: Hemmings Samuel J. , Rhodes Johanna L. , Fisher Matthew C. 
Published: June 2023

AbstractAspergillus fumigatus is a genetically diverse fungal species, which is near ubiquitous in its global distribution and is the major cause of the life-threatening disease invasive aspergillosis. We present 3 de novo genome assemblies that were selected to be representative of the genetic diversity of clinical and environmental A. fumigatus. Sequencing using long-read Oxford Nanopore and subsequent assembly of the genomes yielded 10–23 contigs with an N50 of 4.05 Mbp to 4.93 Mbp.
Counteracting effects of soil biota on emergence and growth of herbaceous plants
Authors: Perea Antonio J. , Merelas Meijide Belén , Alguacil María del Mar , Prieto-Rubio Jorge , Azcón-Aguilar Concepción , Alcántara Julio M. , Garrido José L. , López-García Álvaro 
Published: June 2023

Abstract
Background
Plants condition the biotic composition of their rhizosphere. In turn, this plant legacy on the soil biota may affect the performance of plants recruiting in their vicinity. Unravelling how plant-soil legacies drive plant recruitment is key to understand vegetation dynamics and plant community assembly. Studies on the topic usually focus on the effects of soil microbiota as a whole, while the relative role of different guilds of soil organisms in the plant recruitment processes is not usually dissected.

Aims
Here, we used soils of Mediterranean woody plant species to test whether arbuscular mycorrhizal fungi (AMF) and small-size microbiota (< 50 µm) (MB) affect the germination success and growth of eight herbaceous plants.

Results
We documented a significant increase in seedling emergence probability when small-sized MB was present and no effect of AMF. In contrast, the aboveground plant biomass decreased with the presence of MB and increased with that of AMF. Interestingly, those plants growing in the absence of MB and in soils from woody plants associated with higher AMF richness developed higher aboveground biomass.

Conclusion
This study brings new evidence on how soil microbial communities can determine the performance of their associated herb community, and also, how the effects of different microbial guilds may change across the plant ontogeny. Given these results, the differential effect of soil microbial functional guilds should be considered to better understand plant soil legacies and feedbacks, potentially driving plant recruitment and community assembly.
The synergistic response of primary production in grasslands to combined nitrogen and phosphorus addition is caused by increased nutrient uptake and retention
Authors: Vázquez Eduardo , Borer Elizabeth T. , Bugalho Miguel N. , Caldeira Maria C. , McCulley Rebecca L. , Risch Anita C. , Seabloom Eric W. , Wheeler George R. , Spohn Marie 
Published: June 2023

Abstract
Background and aims
A synergistic response of aboveground plant biomass production to combined nitrogen (N) and phosphorus (P) addition has been observed in many ecosystems, but the underlying mechanisms and their relative importance are not well known. We aimed at evaluating several mechanisms that could potentially cause the synergistic growth response, such as changes in plant biomass allocation, increased N and P uptake by plants, and enhanced ecosystem nutrient retention.

Methods
We studied five grasslands located in Europe and the USA that are subjected to an element addition experiment composed of four treatments: control (no element addition), N addition, P addition, combined NP addition.

Results
Combined NP addition increased the total plant N stocks by 1.47 times compared to the N treatment, while total plant P stocks were 1.62 times higher in NP than in single P addition. Further, higher N uptake by plants in response to combined NP addition was associated with reduced N losses from the soil (evaluated based on soil δ15N) compared to N addition alone, indicating a higher ecosystem N retention. In contrast, the synergistic growth response was not associated with significant changes in plant resource allocation.

Conclusions
Our results demonstrate that the commonly observed synergistic effect of NP addition on aboveground biomass production in grasslands is caused by enhanced N uptake compared to single N addition, and increased P uptake compared to single P addition, which is associated with a higher N and P retention in the ecosystem.
Finally! How time lapse in Nobel Prize reception affects emotionality in the Nobel Prize banquet speeches
Authors: Aranzales Iván , Chan Ho Fai , Torgler Benno 
Published: May 2023

AbstractWe have a limited understanding of the role emotions play in academia, as exploring emotions consistently and comparably is challenging due to the powerful influence of contextual factors. However, we have identified an interesting setting to empirically investigate the emotional response in academia by examining Nobel Prize winners. Scientists who aspire to earn a Nobel Prize are under pressure from their environment if they have not yet received the Prize. While there are various indicators that suggest the Nobel Prize is forthcoming, the question of “when” weighs heavily on the minds of leading candidates. Consequently, waiting for the Nobel Prize is emotionally taxing. We therefore hypothesize that Nobel laureates who have experienced a prolonged wait for the award would feel a stronger sense of relief upon receiving it. We are interested in measuring their level of emotionality after receiving the Nobel Prize by analyzing their banquet speeches using linguistic content analysis. Banquet speeches provide a consistent and controlled setting to compare emotionality across scientists and over time, as we can measure the same responses to the same recognition under the same circumstances. We expect that waiting longer for the Nobel Prize will increase the positive emotionality of Nobelists’ speeches. The waiting time is determined by calculating the years since the Nobel Prize-winning work was performed. By conducting this time-lapse study, we find a robust positive correlation between waiting time and positive emotions in Nobel Prize banquet speeches. We conclude that scientists who waited longer for the Nobel Prize reported higher levels of positive emotions during their speeches.
A novel methodology to disambiguate organization names: an application to EU Framework Programmes data
Authors: Ancona Andrea , Cerqueti Roy , Vagnani Gianluca 
Published: May 2023

AbstractThe concept of collaborative R&D has been increasing interest among scholars and policy-makers, making collaboration a pivotal determinant to innovate nowadays. The availability of reliable data is a necessary condition to obtain valuable results. Specifically, in a collaborative environment, we must avoid mistaken identities among organizations. In many datasets, indeed, the same organization can appear in a non-univocal way. Thus its information is shared among multiple entities. In this work, we propose a novel methodology to disambiguate organization names. In particular, we combine supervised and unsupervised techniques to design a “hybrid” methodology that is neither fully automated nor completely manual, and easy to adapt to many different datasets. Thus, the flexibility and potential scalability of the methodology make this paper a worthwhile contribution to different research fields. We provide an empirical application of the methodology to the dataset of participants in projects funded by the first three European Framework Programmes. This choice is because we can test the quality of our procedure by comparing the refined dataset it returns to a well-recognized benchmark (i.e., the EUPRO database) in terms of the connection structure of the collaborative networks. Our results show the advantages of our approach based on the quality of the obtained dataset, and the efficiency of the designed methodology, leaving space for the integration of affiliation hierarchies in the future.
The Effects of the COVID-19-induced Lockdown on the Social Capital and Cultural Capital in Italy
Authors: Menardo Elisa , Viola Marta , Bacherini Alice , Angelini Luana , Cubelli Roberto , Balboni Giulia 
Published: June 2023

AbstractThe present study investigated the effects of the first COVID-19 lockdown on the Cultural and Social Capitals in Italy in a large group of adults (n = 1125). The relationships between the COVID-19 spread and participants’ Cultural Capital, Social Capital, educational level, occupational prestige, and age were studied using structural equation models. For women but not for men, pandemic spread was positively affected by occupational prestige and it had a positive relationship with their Social Capital (women: CFI = 0.949; RMSEA = 0.059 [CI = 0.045-0.075]; men: CFI = 0.959; RMSEA = 0.064 [CI = 0.039–0.087]). Moreover, the participants were divided into three validated clusters based on their Cultural and Social Capitals levels to investigate changes in the Capitals compared with the pre-lockdown period. It was found that the lockdown contributed to improving the gap among individuals increasing high levels and decreasing low levels of both the Capitals. People with high Cultural and Social Capitals seemed to have seized the opportunity given by COVID-19 restrictions to cultivate their cultural interests and become more involved within their networks. In contrast, individuals with low Cultural and Social Capitals paid the highest price for the social isolation. Given that the Capitals encourage healthy behavior and influence well-being and mental health, institutions should develop or improve their policies and practices to foster individual resources, and make fairer opportunities available during the pandemic.
Zonal origin of prostate cancer: comparison of long-term outcomes after radical prostatectomy
Authors: Luttrell Laura , Li Jian , Cohen Ronald J. 
Published: May 2023

Abstract
Purpose
To assess the impact of zonal origin on positive bladder neck (BN) margins and prostate-specific antigen (PSA) failure or early adjuvant therapy in the patients with complete long-term follow-up after radical prostatectomy (RP).

Methods
A set of 4512 men were identified who underwent RP in Western Australia (WA) from March 2000 to December 2016 and had complete long-term follow-up. The t-test, Pearson chi-square test and Kaplan–Meier method with the log-rank test were used to evaluate differences between the transition zone (TZ) and peripheral/central zone (PZ/CZ) cancer. Univariate and multivariable Cox proportional hazard regression models were applied to assess parameters on PSA failure and early treatment.

Results
The positive BN margin rate for TZ cancer fell significantly over the study period. However, BN margin rates increased for PZ/CZ cancer over the time. Data of 4512 patients with median follow-up of 9.1 years confirmed that the high-risk TZ tumours with negative margins had a significant lower rate of PSA failure or early treatment compared to those high-risk PZ/CZ tumours with negative margins.

Conclusion
Prostate cancer zonal origin significantly impacts long-term biochemical outcomes in high-risk and margin-negative patients. BN invasion with margin involvement is more frequent in the TZ cancer and can be reduced by pre-operative identification of cancer zonal origin and adjustment of surgical procedures.
Development of a multiplex quantitative PCR assay for simultaneous detection of Treponema phagedenis, Treponema pedis, Treponema medium, and ‘Treponema vincentii’ and evaluation on bovine digital dermatitis biopsies
Authors: Frosth Sara , Eriksson Hanna K. , Rosander Anna 
Published: June 2023

AbstractBovine digital dermatitis (BDD) is a contagious foot disease with worldwide occurrence in dairy cattle. The disease causes lameness and reduced animal welfare as well as economic losses for the farmer. The aetiology is not fully established but associations have been made with Treponema spp. Today, BDD diagnosis is mainly based on visual inspection of cattle feet, therefore this study aimed to develop a multiplex quantitative PCR (qPCR) assay targeting Treponema phagedenis, Treponema pedis, Treponema medium, and ‘Treponema vincentii’ to aid in diagnosis. The assay was tested for specificity on 53 bacterial strains and in silico on 168 Treponema spp. genomes, representative of at least 24 species. In addition, 37 BDD biopsies were analysed and the results compared to another qPCR assay published during the study period, which we modified by combining into a multiplex qPCR. The qPCR developed herein had a detection limit of 10 copies of each target species per PCR reaction. Both qPCR assays showed 100% specificity when tested on bacterial strains, but the qPCR developed in this study detected 3.4% more T. phagedenis-positive biopsies of lesion category M1-M4.1 than the modified assay. To conclude, the developed qPCR assay detecting T. phagedenis, T. pedis, T. medium, and ‘T. vincentii’ has high analytical sensitivity and specificity and provides a useful complementary tool for diagnosis and epidemiological studies of BDD. The assay could possibly also be used for contagious ovine digital dermatitis (CODD) as similar bacteriological profiles have been suggested for BDD and CODD, especially regarding certain Treponema spp.
Midhaul Performance Modelling Using Commodity Hardware C-RAN Testbed
Authors: Malm Nicolas , Ruttik Kalle , Tirkkonen Olav 
Published: May 2023

AbstractMidhauls introduce new characteristics to wireless networks. We study implementation performance behaviour to make appropriate network and algorithm design decisions soft–real-time midhaul-based radio access network implementations. A model is developed based on data obtained using a testbed, which can be used to estimate midhaul latency as a function of the number of communicating nodes. The testbed comprises one central unit (CU) controlling a variable number of distributed units (DU) synchronized over Precision Time Protocol (PTP). Average reporting latencies of $$266~\upmu \hbox {s}$$

266

μ
s

were observed with 16 DUs. Typical jitter performance was 99.99 % of values below $$471.75~\upmu \hbox {s}$$

471.75

μ
s

but maximum values up to an order of magnitude larger. Variations in performance of up to 16.2 times more deadline misses were observed between best and worst performing DUs. A model fitted to the obtained data estimates the latency and jitter of CU-DU communication as a function of the number DUs. Results indicate suitability for application with moderate synchronization requirements, for example positioning, but insufficient for the most stringent uses case such ultra-reliable communication.
A comparison of 210Pbxs, 137Cs, and Pu isotopes as proxies of soil redistribution in South Spain under severe erosion conditions
Authors: Peñuela A. , Hurtado S. , García-Gamero V. , Mas J. L. , Ketterer M. E. , Vanwalleghem T. , Gómez J. A. 
Published: June 2023

Abstract
Purpose
The use of fallout radionuclides as proxies for the study of soil redistribution processes in semiarid environments of Southern Spain has been restricted to 137Cs. The potential and limitations of alternative proxies such as 239+240Pu and 210Pbxs should be explored given the expected constrains imposed by the features of the study area.

Materials and methods
Four soil and one sediment cores were collected in a highly eroded area to test the feasibility of these proxies under demanding conditions. The use of gamma spectrometry and ICP-MS did allow exploring the potential of 210Pbxs and Pu isotopes against the well-established tracer, 137Cs. The activity ratios 239+240Pu/137Cs were explored to evaluate the previous evolution of the sampling sites. Soil redistribution rates were estimated using the model MODERN.

Results and discussion
Despite all the profiles showed intense perturbation, Pu isotopes showed the highest potential thanks to higher sensitivity and sample throughput. The deviations of 239+240Pu/137Cs inventory ratios (0.012–0.158) from the global fallout average (0.026 ± 0.003) suggest that the sediment core was a deposition site involving alternate episodes of topsoil removal and incorporation from different sources. The calculated erosion rates ranged 34–43 t ha−1 year−1, being in good agreement for 137Cs and 239+240Pu. 210Pbxs was not used due to low-quality data.

Conclusions
The use of Pu as a tracer of soil redistribution processes in semiarid areas seems to be promising even under severe erosion conditions. The use of 210Pbxs is not recommended in this area due to its low concentration.

Graphical Abstract
What are the experiences of supportive care in people affected by brain cancer and their informal caregivers: A qualitative systematic review
Authors: Paterson C. , Roberts C. , Li J. , Chapman M. , Strickland K. , Johnston N. , Law E. , Bacon R. , Turner M. , Mohanty I. , Pranavan G. , Toohey K. 
Published: May 2023

Abstract
Purpose
To critically synthesise qualitative research to understand experiences of supportive care in people affected by brain cancer and their informal caregivers.

Methods
A qualitative systematic review was conducted according to the Joanna Briggs methodology and has been reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Guidelines. Electronic databases were searched by an expert systematic review librarian for all qualitative studies irrespective of research design. All publications were double screened by two reviewers using a pre-determined exclusion and inclusion criteria. The review was managed using Covidence systematic review software. Methodological quality assessment and data extraction were performed. Qualitative findings accompanied by illustrative quotes from included studies were extracted and grouped into categories, which created the overall synthesised findings.

Results
A total of 33 studies were included which represented a total sample of 671 participants inclusive of 303 patients and 368 informal caregivers. There was a total of 220 individual findings included in this review, which were synthesised into two findings (1) caregivers and patients perceived supports which would have been helpful and (2) caregiver and patient experiences of unmet supportive care needs.

Conclusion
This review highlighted the suffering and distress caused by brain cancer and associated treatments. Both patients and their informal caregivers experienced disconnect from themselves in renegotiating roles, and a profound sense of loneliness as the physical deterioration of the disease progressed. Both patients and informal caregivers reported similar unmet needs within the current service provision for brain cancer. However, what is apparent is that current cancer services are provided solely for patients, with little or no consideration to the support needs of both the patient and their informal caregiver. Service re-design is needed to improve care coordination with individualised informational support, implementation of holistic needs assessments for both the patients and their caregivers, better community support provision, improved opportunities for emotional care with early referral for palliative care services.

Implications for cancer survivors
It is recommended that members of the multidisciplinary brain cancer team reflect on these findings to target holistic needs assessments and develop shared self-management care plans for both the patient and the informal caregiver.
Erectile dysfunction and metabolic syndrome components in obese men with psoriasis: response to a 12-week randomized controlled lifestyle modification program (exercise with diet restriction)
Authors: Ismail Ali Mohamed Ali , Hamed Dina E. 
Published: May 2023

Abstract
Background
Erectile dysfunction (ED) and metabolic syndrome (MeTS) are highly prevalent in chronic plaque psoriasis (CPP).

Objective
The aim of this lifestyle modification study is to explore the response of MeTS components and ED to a 12-week lifestyle modification program (low-calorie diet and moderate-intensity treadmill walking) in 60 obese men with CPP, mild and moderate ED, and MeTS.

The design, settings, participants, and intervention
In this lifestyle modification randomized study, a university-based hospital recruitment of 60 obese men with CPP, mild and moderate ED, and MeTS was randomly performed. Men were randomly assigned to the lifestyle modification group (n = 30, received low-calorie diet and moderate-intensity treadmill walking programs) or waitlist group (n = 30). The following outcomes were assessed as follows: body mass index, psoriasis severity (assessed via psoriasis area and severity index), ED (assessed by the five-item internal index of erectile function), and components of MeTS (waist circumference, blood pressure, serum high-density lipoprotein, serum triglycerides, and serum fasting blood glucose).

Results
Trends of significant improvements in all outcomes were documented in favor of the lifestyle modification group. All outcomes of the waitlist group did not show the same reported significant improvements of the lifestyle modification group.

Conclusion
A 12-week lifestyle modification program as a tool for weight loss in obese men with CPP is a good therapeutic method to improve psoriasis severity and psoriasis-associated ED and MeTS.