bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of neoadjuvant chemoradiation therapy is independent of intratumoral vascularization in resectable pancreatic cancer
Authors: Yasue Tomomi , Ashida Reiko , Takada Ryoji , Ikezawa Kenji , Ohkawa Kazuyoshi , Nagata Shigenori , Teshima Teruki , Akita Hirofumi , Takahashi Hidenori , Doki Yuichiro , Eguchi Hidetoshi 
Published: May 2023

Abstract
Background Neoadjuvant chemoradiation therapy (NACRT) is a multidisciplinary treatment for pancreatic cancer (PC) in which the effect of anticancer drugs depends on intratumoral blood flow. Most PCs are hypovascular; however, the additional effects of radiation therapy on drug efficacy are unclear. We investigated the relationship between PC vascularity and the therapeutic effect of NACRT using contrast-enhanced harmonic EUS (CH-EUS).Methods Patients with resectable PC who underwent CH-EUS followed by NACRT were analyzed retrospectively. The CH-EUS enhancement pattern was evaluated in the vascular and perfusion phases, and classified according to vascularity: Group A, hypovascular in both phases; Group B, isovascular and hypovascular in the vascular and perfusion phases, respectively; Group C, isovascular in both phases. The relationship between CH-EUS vascular pattern and the histological effect of NACRT, recurrence-free survival (RFS), and overall survival (OS) were assessed.Results Of 48 enrolled patients, 31, 11, and 6 were classified into Groups A, B, and C, respectively. There was no significant difference in histopathological differentiation, efficacy of NACRT, median RFS or OS among the groups.Conclusions There was no significant difference in the histopathological efficacy of NACRT for resectable PC in terms of the enhancement pattern of CH-EUS. NACRT may provide additional therapeutic effect regardless of blood flow.
Modelling nicotine pharmacokinetic profile for e-cigarette using real time monitoring of consumer’s physiological measurements and mouth level exposure
Authors: Prasad Krishna , Griffiths Allen , Agrawal Kavya , McEwan Michael , Macci Flavio , Ghisoni Marco , Stopher Matthew , Napleton Matthew , Strickland Joel , Keating David , Whitehead Thomas , Conduit Gareth , Murray Stacey , Edward Lauren 
Published: May 2023

Abstract

Pharmacokinetic (PK) studies can provide essential information on abuse liability of nicotine and tobacco products but are intrusive and must be conducted in a clinical environment. The objective of the study was to explore whether changes in plasma nicotine levels following use of an e-cigarette can be predicted from real time monitoring of physiological parameters and mouth level exposure (MLE) to nicotine before, during, and after e-cigarette vaping, using wearable devices. Such an approach would allow an -effective pre-screening process, reducing the number of clinical studies, reducing the number of products to be tested and the number of blood draws required in a clinical PK study Establishing such a prediction model might facilitate the longitudinal collection of data on product use and nicotine expression among consumers using nicotine products in their normal environments, thereby reducing the need for intrusive clinical studies while generating PK data related to product use in the real world.
A machine learning model was developed to predict changes in plasma nicotine levels following the use of an e-cigarette; from real time monitoring of physiological parameters and MLE to nicotine before, during, and after e-cigarette vaping. This preliminary study identified key parameters, such as heart rate (HR), heart rate variability (HRV), and physiological stress (PS) that may act as a predictors for an individual’s plasma nicotine response (PK curve). Relative to baseline measurements (per participant), HR showed a significant increase for nicotine containing e-liquids and was consistent across sessions (intraparticipant). Imputing missing values and training the model on all data resulted in 57% improvement from the original ’learning’ data and achieved a median validation R2 of 0.70.
Diagnostic value of transvaginal color Doppler ultrasonography findings in post treatment follow up of cesarean scar pregnancy
Authors: Sodabi Maryam , Karbasi Mahsa , Eghbali Elham , Abbasalizadeh Fatemeh , Razmifard Farzad , Azari Mojtaba , Ahangar-sirous Ramin , Shahestan Alireza Omara , Alihosseini Samin 
Published: May 2023

Abstract
Aim: Cesarean scar pregnancy can cause life-threatening complications for pregnant women, so early diagnosis and treatment is crucial for prevention of maternal mortality. Transvaginal color Doppler ultrasonography besides serum β-hCG level follow-up can be a noninvasive and proper method for post-treatment follow-up of a cesarean scar pregnancy. In the present study, we investigated the Doppler resistance index changes in cesarean scar pregnancies after medical management together with sac diameter and serum β-hCG level measurement.
Methods: 28 patients with cesarean scar pregnancy and a history of previous cesarean delivery, gestational age of less than 9 completed weeks at ultrasonography, decision to medical management by gynecologist and with having a β-hCG level before treatment were enrolled and initially examined by ultrasound and Doppler studies. The resistance index of the closest myometrial artery to cesarean scar pregnancy mass and its diameter were measured. After 72 hours, 1 week and 2 weeks after medical therapy, mentioned variables were measured again and were compared to the values of the pretreatment time point.
Results: Resistance index values were significantly higher in all of the follow-up time points compared with the pretreatment time points, while serum β-hCG levels were significantly lower. Moreover, sac diameter values were increased 72 hours post-treatment and then declined.
Conclusions: Serial Doppler ultrasound examinations can be a useful method to evaluate the success or failure of medical management of cesarean scar pregnancies as the increase in resistance index values occur rapidly after medical treatment and correlate well with serum β-hCG levels.
Evaluation of the treatment of distal radial volar fracture by different methods sparing the pronator quadratus
Authors: Huang Xiaoxia , Liu Tao , Xue Zhaoxi , Wu Boyu , Kong Weiqi , Ye Kai , Jia Qiyu , Teng Yong , Zhao Yan 
Published: May 2023

Abstract
Background The conventional volar approach requires the release of the pronator quadratus (PQ) muscle in the treatment of distal radius fractures. However, releasing PQ muscle could cause loss of function and a host of complications.Aim This study compared the outcomes of different methods of sparing the PQ muscle combined with volar plate in the treatment of distal radius fractures.Methods A total of 68 patients with distal radius fractures were enrolled with either the brachioradialis (BR) splitting approach (Group A,33 people) or through the tunnel behind the PQ muscle approach (Group B,35 people). Postoperative internal fixation, fracture healing and postoperative complications were observed in the two groups. The visual analog scale (VAS) of postoperative wrist pain was compared between the two groups. The Dienst joint scale was used to evaluate the wrist function of patients, and imaging indexes were used to evaluate the surgical efficacy.Results A total of 68 patients with distal radius fractures were followed up for more than 1 year after surgery. All fractures obtained good union, with no vascular injury, nerve injury, or wound infection. There was no significant difference in the baseline characteristics of both groups. Outcomes at 3 days,1 month,and 3 months all showed no significant differences in postoperative imaging indexes between the two groups. There were significant differences in the mean operative time between the two groups. Nevertheless, no significant differences were shown in mean operative blood loss and mean bone union time between the two groups. There was no significant difference in the results of complications between the two groups. No significant differences in limb function scores, VAS scores and the mean range of motion existed the two groups at the 12-month postoperative follow-up. However, outcomes assessed at 1 week, 1 month, and 3 months after surgery demonstrated significant differences in the VAS scores and the mean range of motion between the two groups.Conclusion Our results demonstrated that these two different surgical approaches were effective ways to reserve PQ and had good clinical outcomes. Placing the plate under the quadratus muscle could reduce early postoperative pain, promote early activity, and returned to normal life. The BR splitting approach was more advantageous in intraoperative fracture exposure and could shorten the operative time. However, some defects also existed. Therefore, surgeons should be aware of their individual characteristics and chose patients carefully.
A novel higher-order numerical method for parabolic integro-fractional differential equations based on wavelets and $L2$-$1_\sigma$ scheme
Authors: Santra Sudarshan , Behera Ratikanta 
Published: May 2023

Abstract
This paper aims to construct an efficient and highly accurate numerical method to solve a class of parabolic integro-fractional differential equations, which is based on wavelets and L2-1σ scheme; specifically, the Haar wavelet decomposition is used for grid adaptation and efficient computations, while the high order L2-1σ scheme is taken into account to discretize the time-fractional operator. In particular, second-order discretizations are used to approximate the spatial derivatives to solve the one-dimensional problem. In contrast, a repeated quadrature rule based on trapezoidal approximation is employed to discretize the integral operator. On the other hand, we use the semi-discretization of the proposed two-dimensional model based on the L2-1σ scheme for the fractional operator and composite trapezoidal approximation for the integral part. Then, the spatial derivatives are approximated by using the two-dimensional Haar wavelet. Here, we investigated theoretically and verified numerically the behavior of the proposed higher-order numerical method. In particular, the stability and convergence analysis of the proposed higher-order method has been studied. The obtained results are compared with some existing techniques through several graphs and tables, and it is shown that the proposed higher-order methods have better accuracy and produce less error compared with the L1 scheme.
MSC Classification: 45K05 , 45D05 , 26A33 , 65M06
Modeling the effects of climate change on the habitat suitability of Mediterranean gorgonians
Authors: Bellin Nicolò , Rossi Valeria 
Published: May 2023

Abstract

Multiple stressors including global warming increasingly threaten the distribution and abundance of gorgonian forests. We built species distribution models (SDM) combined with machine learning algorithms, to compare the ecological niche of three Mediterranean gorgonian species (Paramuricea clavata,Eunicella cavoliniiandEunicella singularis)and distribution response to climate change under the worst IPCC scenario RCP8.5. Three Machine Learning models, XGBoost, Random Forest and the K-nearest neighbour, 23 physico-chemical and 4 geophysical environmental variables were used to obtain the potential habitat suitability and future projections (2040–2050) of their distribution in the Mediterranean Sea. The global sensitivity and uncertainty analysis was used to identify the most important environmental variables shaping the habitat suitability of the species and to disentangle the interaction terms among different environmental variables. For all species, bathymetry was the main variable influencing habitat suitability, with higher interactions with silicate, salinity and concavity. In future climatic conditions,P. clavatawas expected to shift its habitat suitability from lower to higher latitudes, mainly in the Adriatic Sea. For bothE. cavoliniiandE. singularis, a general habitat reduction was predicted. In particular,E. cavoliniiwas expected to reduce the occupancy area of 49% suggesting that the sensitivity of the symbiotic algae (zooxanthellae) may not be the main responsible of the corresponding susceptibility of the holobiont to thermal stresses and climate change.
Hip and knee replacements performed in Colombia between 2012 and 2021, burden and tendencies. A perspective from SISPRO
Authors: Useche Luis Fernando , Gaitan-Lee Hernando , Mejía-Grueso Alejandro , Monroy-Rivera Mateo 
Published: May 2023

Abstract

The Colombian Ministry of Health and Social Protection (MHSP) gathers timely, sufficient, and standardized information for decision-making in the health sector through the Integrated Social Protection Information System (SISPRO). This system is made up of databases and information systems on supply and demand of health services, quality, insurance, financing, social promotion.(1) This project seeks to evaluate the information contained in this database, referring to the number of primary hip and knee joint replacements that were performed in Colombia, in the period 2012–2021 and describe their distribution in terms of age, sex, insurance system, and geographical location. There is currently no information reported nor analyzed regarding this topic. Through a pivot table, fed by the SISPRO cubos3 database; crosses of variables were carried out to obtain information on the number of partial or total joint replacements executed in Colombian territory; describing distributions by age in decades, sex, insurance regime and geographical distribution by Departments. The historical number of replacements in Colombia between 2009 to 2014 is described. This allows us to establish behavior in the last decade. The effect of the COVID-19 pandemic is also described. In Colombia, an average of 5698 (sd.851) hip replacements and 5005 (sd.1156) knee replacements were performed each year during the last decade (2012–2021). An increasing trend in hip and knee replacements of 5% per year and 10.8% annual total, was observed. The trend in 2020 was affected, as expected by COVID-19 pandemic. This trend was highly affected in knee replacements, with a 32% decrease compared to 2019, whilst hip replacements only decreased 9%. In 2021, the downward trend persisted compared to the previous year, with a 16% decrease in knee replacements and a 6% decrease in hip replacements. Similarly, hip and knee replacements predominated in women, 65% and 71% respectively. Most of these procedures were done in females over the age of 50. The state insurance system sponsors 90% of the procedures, the subsidized regime predominates over the contributory one. Geographically, the largest number of replacements are made in Bogota (Cundinamarca), Medellin (Antioquia) and Cali (Valle del Cauca). There was an important number of hip replacements done in Pasto (Nariño) and Bucaramanga (Santander). On the other hand, it was significantly important to state that in Bucaramanga (Santander) and Barranquilla (Atlantico) there was a high volume of knee replacements done per year. The reliability of this registry lies in the multiple official sources of the MHSP and in the national coverage of the General Social Security System in Health (GSSSH), which according to official data from the MHSP, is above 90% throughout the reporting period.
A Fourier descriptor and PSCS-RBF fusion method for pumping machine fault diagnosis
Authors: Bowen Li , Raja S Selvakumar , Jiajun Li , Zejun Yao , Wenguang Song , Haoyuan Li , Changtao Lan , Mawien Kon 
Published: May 2023

Abstract
For the current oilfield pumping machine fault diagnosis, there are time-consuming and inefficient problems, and at the same time high requirements for hardware resources and no universality, this study proposes a pumping machine fault diagnosis method based on improved Fourier descriptor combined with dynamic adaptive cuckoo search (PS cuckoo search, PSCS) to optimize RBF neural network. Firstly, the starting point position of the contour of the power diagram is determined by the minimum inertia axis, and the Fourier transform is performed to achieve the best matching between contours, and the effect of starting point irrelevance. Then feature extraction is performed by combining shape invariant moments as the input layer information of RBF neural network. Then dynamic discovery probability and adaptive step size are introduced to make the cuckoo search easier to retain the better solution, and the step size can be automatically adjusted according to the convergence rate of the objective function to maintain a balanced state of efficiency and accuracy in different search stages. Finally, the RBF neural network is optimized by the improved cuckoo search to obtain the optimal relevant parameters such as the width and weights of RBF, and the PSCS-RBF fault diagnosis model is established. The model is applied to the diagnosis of different fault types of pumping machines and is compared and analyzed with a variety of current mainstream models. The average detection accuracy of the PSCS-RBF fault diagnosis method proposed in the article reaches 96.3%, and the measured results have high accuracy and short time, which verifies the practical value and advantages of the method.
The effects of warm compress therapy on the stability of the tear film in dogs
Authors: Kim Jury , Ji Dong-beom , Jung Sun-jun , Seo Dae-yun , Kim Min-Su 
Published: May 2023

Abstract

Background
Meibomian gland dysfunction (MGD) is defined as functional abnormalities of the meibomian gland and is commonly caused by meibomian gland hyposecretion or obstruction. This results in an improper tear lipid layer which increases the tear evaporation and makes the tear film instability, leading to qualitative dry eye disease. In humans, a mainstay of the management of MGD is eyelid warming. This improves meibum secretion by melting pathologically altered meibomian lipids. While nearly ubiquitous in human medicine, there are no reports of the effects of warming therapy on the eyelids in veterinary medicine. This study is to evaluate the effect of warm compress therapy on canine tear film quality parameters. Eight systemically healthy male Beagle dogs with normal ophthalmic examinations (16 eyes) were used for this study. The temperature of the outer upper eyelid, the upper palpebral conjunctiva, and the central cornea were evaluated with an infrared thermometer, and tear film quality was assessed with meibometry and evaluation of the tear film break up time (TFBUT). These parameters were measured before and immediately following the application of the warm compress. A paired t-test was used to compare the data before and after warm compress treatment. For statistical analysis, SPSS was used and a P value < 0.05 was considered significant.
Results
All parameters increased after warm compression. The temperature of the outer and upper palpebral eyelid, and the central cornea increased significantly, from 34.0±1.0°C to 35.3±1.0°C, from 34.2±0.8°C to 35.5±0.8°C, from 34.2±0.8°C to 35.0±0.7°C, respectively. In meibometry, the mean±SD meibomian level at the baseline was 109.0±44.1 MU, whereas after warm compress therapy, it significantly increased to 155.9±71.3MU (p<0.05). TFBUT increased from 8.9±3.0 to 10.5±2.3 seconds.
Conclusions
Application of warm compress to the external eyelids has a significant effects of tear film quality parameters and may be useful to improve tear film stability in dogs.
Postnatal Kangaroo Mother Care practice at home in Low-birth-weight babies in rural coal mines area West Bokaro Jharkhand, India: A Community-Based Prospective Observational Study
Authors: Prasad Tulsi , Roy Ashish 
Published: May 2023

Abstract
Background Low birth weight (LBW) newborns especially those < 2000 gms are more prone to hypothermia due to which other physiological parameters gets deteriorated in 1st week of life. The objective of this observational study was to continue Kangaroo Mother Care practice at home and ascertain whether KMC was effective in improving the vital parameters of LBW babies when given at home in a rural coal mines area, in Jharkhand, India.Methods This study was a community-based prospective observational study, done over three years from November 2019 to November 2022. This study included 156 pairs of both mothers and LBW babies (weight 1500 to < 2000 gm). After discharge from the hospital on day 3, KMC was continued at home on day 4, day 5, and day 6. Data of four physiological parameters, temperature, oxygen saturation, respiratory rate, and heart rate, were collected before and after KMC and analyzed.Results Among 400 newborns, 156 LBW babies (39.0%) who were given KMC at home, showed similar but statistically significant improvement of vital parameters, especially in temperature and oxygen saturation(p < 0.0001) compared to the same babies 156(39.0%) given KMC in the hospital (p < 0.001).Conclusion Kangaroo Mother Care, which was continued at home, has a significant role in the Improvement of vital parameters, especially concerning temperature and oxygen saturation. If the babies in the weight range of 1500 to < 2000 gm are healthy, well-breast fed, and have no other risk factors can be discharged early, and managed at home by delivering supportive care, nursing care along with Kangaroo Mother Care with continuous follow-up.
Vibration Control of High-rise Building Via Optimal TMD for Earthquake by Black Window with Elman Model
Authors: Vanshaj Kumar , K Shukla A , Shukla Mukesh , Mishra Abhishek 
Published: May 2023

Abstract
Tuned Mass Dampers (TMDs) are a useful control gadget to diminish undesired vibrations of tall buildings and gigantic reach ranges against equal burdens like breezes and earthquakes. The better limits for TMD are to reduce the earthquake vibrations of tall buildings; including Soil-Plan Interaction (SSI) influences. The chief mark of this survey is to upgrade the limits of TMD presented to earthquakes and consider the effects of SSI. This study proposes the multi-objective Black Window Optimization (BWO) with Elman Neural Network (ENN) computation is brought on to find the optimal limits of TMD. Considering this procedure redesign the TMD including mass, stiffness, and damping to get the most noteworthy accelerations and displacement of 40 story building model. This is accomplished through restricted part diversions in which soil-structure interaction is depicted by extraordinary impedance capacities, to have computationally capable models to focus on the properties of the soil-structure system. The results are conveyed to the extent that non-layered execution twists of the TMD addressing soil-structure interaction and this proposed procedure is the execution of the MATLAB stage. From the execution results, this proposed BWO-Elman model differentiated and customary methodology, the most outrageous TMD limits are better, likewise, this study assists the researchers with a bettering understanding of earthquake vibrations, and leads the fashioners to achieve the superior TMD for tall designs.