bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective study assessing outcomes in cardiac surgery after implementation of Quantra
Authors: Tibi Pierre , Thompson Jess , Attaran Saina , Black Elizabeth 
Published: April 2023

Abstract
Background
The Quantra QPlus System is a cartridge-based device with a unique ultrasound technology that can measure the viscoelastic properties of whole blood during coagulation. These viscoelastic properties correlate directly with hemostatic function. The primary objective of this study was to assess blood product utilization in cardiac surgery patients before and after the implementation of the Quantra QPlus System.

Methods
Yavapai Regional Medical Center implemented the Quantra QPlus System to aid in their efforts to reduce the transfusion of allogenic blood products and improve outcomes in patients undergoing cardiac surgery. A total of 64 patients were enrolled prior to the utilization of the Quantra (pre-Quantra cohort), and 64 patients were enrolled after (post-Quantra cohort). The pre-Quantra cohort had been managed via standard laboratory assays along with physician discretion for transfusion decisions. The utilization of blood products and frequency of transfusions were compared and analyzed between the two cohorts. (using the Student’s t-test)

Results
The implementation of the Quantra resulted in a change in the pattern of blood product utilization leading to a demonstrated decrease in the amount of blood products transfused and the associated costs. The amount of FFP transfused was significantly decreased by 97% (P = 0.0004), whereas cryoprecipitate decreased by 67% (P = 0.3134), platelets decreased by 26% (P = 0.4879), and packed red blood cells decreased by 10% (P = 0.8027) however these trends did not reach statistical significance. The acquisition cost of blood products decreased by 41% for total savings of roughly $40,682.

Conclusions
Use of the Quantra QPlus System has the potential to improve patient blood management and decrease costs.

Study registered at ClinicalTrials.gov
NCT05501730
Effect of preoperative pulmonary artery pressure on the prognosis of end-stage heart failure patients after heart transplantation
Authors: Zhou Wei , Du Zhen , Tao Yun , Zhang Guan-xin , Xu Zhi-yun , Han Lin , Ma Shao-lin , Hu Dao-xi , Fan Xing-li , Li Bai-ling 
Published: April 2023

Abstract
Objective
To evaluate the effect of preoperative pulmonary artery pressure on perioperative outcome of end-stage heart failure patients undergoing heart transplantation.

Methods
Retrospective analysis was undertaken on the clinical data of patients receiving heart transplantation in the Department of Cardiovascular Surgery of our hospital from March 2017 to March 2022. A ROC curve analysis was developed between mean pulmonary artery pressure (mPAP) and postoperative mortality using mPAP as diagnostic criteria. Patients were divided into groups based on this threshold to determine the best mPAP threshold value for predicting postoperative nosocomial mortality, and the differences in preoperative and intraoperative data, postoperative complications, and clinical prognosis of patients in the two groups were compared. Patients were followed up to draw the survival curve of patients in the two groups.

Results
The study enlisted the participation of 105 patients. ROC curve research revealed that preoperative pulmonary artery pressure was substantially linked with death following heart transplantation, with mPAP = 30.5mmHg being the best threshold. The group with mPAP ≥ 30.5mmHg had a greater incidence of postoperative ECMO support (28.2% vs. 10.6%, P = 0.021) and a higher incidence of in-hospital mortality (15.4% vs. 1.5%, P = 0.019) than the group with mPAP < 30.5mmHg. The postoperative survival rates of 105 patients were 91.3%, 88.7%, 81.6%, and 77.5% at 1, 2, 3, and 4 years, respectively, however, there was no significant difference between the two groups of patients in the postoperative intermediate-far survival rate (P = 0.431).

Conclusions
Preoperative pulmonary artery pressure in patients with end-stage heart failure is intimately correlated with perioperative prognosis of heart transplant recipients. The optimal cut-off mPAP value in predicting perioperative prognosis of heart transplant recipients is 30.5mmHg. In the high mPAP group, perioperative ECMO support rate and perioperative mortality rate are high, which do not affect the medium and long-term prognosis of the recipients undergoing heart transplantation.
Complete thoracoscopic S9 and/or S10 segmentectomy through a pulmonary ligament approach: a retrospective study
Authors: Mitsuboshi Shota , Matsumoto Takako , Omata Motoka , Shidei Hiroaki , Ogihara Akira , Koen Akihiro , Aoshima Hiroe , Isaka Tamami , Kanzaki Masato 
Published: April 2023

Abstract
Background
The high resolution of computed tomography has found the pulmonary ligaments that consists of a double serous layer of visceral pleura, forms the intersegmental septum, and enters the lung parenchyma. This study aimed to investigate the clinical feasibility of thoracoscopic segmentectomy (TS) of the lateral basal segment (S9), posterior basal segment (S10), and both through the pulmonary ligament (PL).

Methods
Between February 2009 and November 2021, 542 patients underwent segmentectomy for malignant lung tumors at Tokyo Women’s Medical University Hospital (Tokyo, Japan). This study included 51 patients. Among them, 40 underwent a complete TS of the S9, S10, or both by the PL approach (PL group), and the remaining 11 by the interlobar fissure approach (IF group).

Results
Patients’ characteristics did not significantly differ between the two groups. In the PL group, 34 underwent video-assisted thoracoscopic surgery (VATS), and 6 underwent robot-assisted thoracoscopic surgery. In the IF group, all 11 underwent VATS. Operation duration, estimated blood loss, and postoperative complication frequency were not significantly different between these groups, but the maximum tumor diameter showed a significant difference.

Conclusions
Complete TS of the S9, S10, and both through the PL is a reasonable option for tumors located in such segments. This approach is a feasible option for performing TS.
GBC: a parallel toolkit based on highly addressable byte-encoding blocks for extremely large-scale genotypes of species
Authors: Zhang Liubin , Yuan Yangyang , Peng Wenjie , Tang Bin , Li Mulin Jun , Gui Hongsheng , Wang Qiang , Li Miaoxin 
Published: April 2023

AbstractWhole
-genome sequencing projects of millions of subjects contain enormous genotypes, entailing a huge memory burden and time for computation. Here, we present GBC, a toolkit for rapidly compressing large-scale genotypes into highly addressable byte-encoding blocks under an optimized parallel framework. We demonstrate that GBC is up to 1000 times faster than state-of-the-art methods to access and manage compressed large-scale genotypes while maintaining a competitive compression ratio. We also showed that conventional analysis would be substantially sped up if built on GBC to access genotypes of a large population. GBC’s data structure and algorithms are valuable for accelerating large-scale genomic research.
Improved analysis of (e)CLIP data with RCRUNCH yields a compendium of RNA-binding protein binding sites and motifs
Authors: Katsantoni Maria , van Nimwegen Erik , Zavolan Mihaela 
Published: April 2023

AbstractWe present RCRUNCH, an end-to-end solution to CLIP data analysis for identification of binding sites and sequence specificity of RNA-binding proteins. RCRUNCH can analyze not only reads that map uniquely to the genome but also those that map to multiple genome locations or across splice boundaries and can consider various types of background in the estimation of read enrichment. By applying RCRUNCH to the eCLIP data from the ENCODE project, we have constructed a comprehensive and homogeneous resource of in-vivo-bound RBP sequence motifs. RCRUNCH automates the reproducible analysis of CLIP data, enabling studies of post-transcriptional control of gene expression.
Vector competence of Anopheles stephensi for O’nyong-nyong virus: a risk for global virus spread
Authors: Mutsaers Maud , Engdahl Cecilia Springer , Wilkman Lukas , Ahlm Clas , Evander Magnus , Lwande Olivia Wesula 
Published: April 2023

Abstract
Background
O’nyong-nyong virus (ONNV) is a mosquito-borne alphavirus causing sporadic outbreaks of febrile illness with rash and polyarthralgia. Up to now, ONNV has been restricted to Africa and only two competent vectors have been found, Anopheles gambiae and An. funestus, which are also known malaria vectors. With globalization and invasive mosquito species migrating to ONNV endemic areas, there is a possible risk of introduction of the virus to other countries and continents. Anophelesstephensi, is closely related to An. gambiae and one of the invasive mosquito species of Asian origin that is now present in the Horn of Africa and spreading further east. We hypothesize that An. stephensi, a known primary urban malaria vector, may also serve as a new possible vector for ONNV.

Methods
One-week-old female adult An.stephensi were exposed to ONNV-infected blood, and the vector competence for ONNV, i.e. infection rates (IRs), dissemination rates (DRs), transmission rates (TRs), dissemination efficiency (DEs) and transmission efficiency (TEs), were evaluated. Infection (IRs), dissemination efficiency (DEs) and transmission efficiency (TEs) were determined. Detection of ONNV RNA was analysed by RT-qPCR in the thorax and abdomen, head, wings, legs and saliva of the infected mosquitoes at four different time points, day 7, 14, 21 and 28 after blood meal. Infectious virus in saliva was assessed by infection of Vero B4 cells.

Results
The mean mortality across all sampling times was 27.3% (95 confidence interval [CI] 14.7–44.2%). The mean rate of infection across all sampling periods was 89.5% (95% CI 70.6–95.9). The mean dissemination rate across sampling intervals was 43.4% (95% CI 24.3–64.2%). The mean TR and TE across all mosquito sampling time intervals were 65.3 (95% CI 28.6–93.5) and 74.6 (95% CI 52.1–89.4). The IR was 100%, 79.3%, 78.6% and 100% respectively at 7, 14, 21 and 28 dpi. The DR was the highest at 7 dpi with 76.0%, followed by 28 dpi at 57.1%, 21 dpi at 27.3% and 14 dpi at the lowest DR of 13.04%. DE was 76%, 13.8%, 25%, 57.1% and TR was 79%, 50%, 57.1% and 75% at 7, 14, 21 and 28 dpi respectively. The TE was the highest at 28 dpi, with a proportion of 85.7%. For 7, 14 and 21 dpi the transmission efficiency was 72.0%, 65.5% and 75.0% respectively.

Conclusion
Anopheles stephensi is a competent vector for ONNV and being an invasive species spreading to different parts of the world will likely spread the virus to other regions.

Graphical Abstract
Screening antivirals with a mCherry-expressing recombinant bovine respiratory syncytial virus: a proof of concept using cyclopamine
Authors: Fix Jenna , Descamps Delphyne , Galloux Marie , Ferret Cécile , Bouguyon Edwige , Zohari Siamak , Näslund Katarina , Hägglund Sara , Altmeyer Ralf , Valarcher Jean-François , Riffault Sabine , Eléouët Jean-François 
Published: April 2023

AbstractBovine respiratory syncytial virus (BRSV) is a pathogenic pneumovirus and a major cause of acute respiratory infections in calves. Although different vaccines are available against BRSV, their efficiency remains limited, and no efficient and large-scale treatment exists. Here, we developed a new reverse genetics system for BRSV expressing the red fluorescent protein mCherry, based on a field strain isolated from a sick calf in Sweden. Although this recombinant fluorescent virus replicated slightly less efficiently compared to the wild type virus, both viruses were shown to be sensitive to the natural steroidal alkaloid cyclopamine, which was previously shown to inhibit human RSV replication. Our data thus point to the potential of this recombinant fluorescent BRSV as a powerful tool in preclinical drug discovery to enable high throughput compound screening.
The effect of innovation orientation on firm performance: evidence from micro and small manufacturing firms in selected towns of Awi Zone, Ethiopia
Authors: Ayinaddis Samuel Godadaw 
Published: April 2023

AbstractInnovation in micro and small enterprises is widely regarded as one of the most important sources of sustainable competitive advantage with an embedded purpose of performance improvement in an increasingly changing environment. This study aimed to examine the effect of innovation on the performance of micro and small manufacturing firms in selected towns of Awi Zone, Amhara, Ethiopia. The target population of the study was 643 micro and small manufacturing firms in Injibara, Dangila, and Tilili; a number provided by Awi zone enterprise development office data during 2021. Data were drawn from a sample of 247 manufacturing firms using cross-sectional primary data collected from wood and metal manufacturing firms in selected towns of Awi Zone. The study adopted descriptive and explanatory designs and used correlation and multiple linear regression analysis to estimate the effect of innovation on firm performance. The regression results revealed that product, process, marketing and organizational innovation were positively and significantly related to firm performance, while product innovation was found to have a strong positive effect on the dependent variable firm performance followed by process and organizational innovation, respectively. However, a weak statistical relationship was reported between marketing innovation and the performance of manufacturing firms than other variables. Hence, firms which have a strong orientation towards product, process, organizational and marketing innovation have better performance in manufacturing firms in the study area.
Emerging technological innovation in Gaza Strip municipalities: an entrepreneurial approach
Authors: AlAstal Ashraf Y. 
Published: April 2023

AbstractTo boost corporate efficiency in both the public and private sectors, innovation is fundamental. Efficient technological transfer and the role of public–private sector collaboration play a major role in the modern growth of knowledge-based economies. As a public service organization, municipalities normally coordinate with all partners to draw up strategies and use them in communities. A new vision is needed for the Gaza Strip municipalities, where all public and private stakeholders work together to co-design and co-develop new cutting-edge products and services aimed at generating shared value through entrepreneurial behavior. However, concrete examples of smart city projects revealed that municipalities often do not have the necessary capabilities as well as innovative approaches to collaborate with start-ups and other stakeholders’ ecosystems. So, this paper aims to analyze innovation in the municipal sector shedding light on the barriers and challenges that municipalities in the Gaza Strip face in smart city development. This study uses primary data gathered from various stakeholders through focus groups, semi-structured interviews, and webinars to conclude how the Gaza Strip municipalities can work to address challenges in the smart city context; and to explore how to promote an ecosystem of entrepreneurship and innovation to support the adoption of new hi-tech technologies in the municipal sector. The Gaza Strip municipalities need to offer the necessary conditions for entrepreneurial talents who can bring their creative mindset, and technological experiences to the table, making it possible to build the best teams to solve any challenge. The research also concluded that Open Innovation Platforms can be seen as an important tool for enabling start-ups and researchers to develop innovative Hi-Tech solutions.
Evaluation of environmental energy efficiency and its influencing factors: a prefecture-level analysis of Japanese manufacturing industries
Authors: Shimizu Masayuki , Tiku Oscar 
Published: April 2023

AbstractThis study evaluates the progress of efficient energy use and the control of carbon dioxide (CO2) emissions in Japan between 1990 and 2012. A new indicator of energy performance is presented called environmental energy efficiency (EEE). The EEE of manufacturing industries was measured by each prefecture in Japan. We estimated the influencing factors of EEE for each industry by applying the pooled mean group (PMG) method. Our findings are as follows: First, the Japanese manufacturing industry has not been in line with the EEE improvement goals since the adoption of the Kyoto Protocol. However, the progress of each industry was relatively consistent by region. Second, EEE tends to improve and then deteriorate or monotonically increase as economic development progresses. Third, EEE is raised by expanding industry share. Finally, EEE, which focuses on energy reduction, is likely to increase with the progress of energy-saving technology.
The application of knowledge graphs in the Chinese cultural field: the ancient capital culture of Beijing
Authors: Bai Bing , Hou Wenjun 
Published: April 2023

Abstract
A methodology is proposed to introduce knowledge graphs into the study of the Chinese cultural field for use in a newly designed, complete application. At present, the combination of culture and information technology has become a trend. Among various technologies, knowledge graphs are a very promising option. The contributions of this paper are as follows: it supplies for the first time a knowledge graph in the cultural field of the ancient capital of Beijing, establishes a domain knowledge base, and develops a platform for visual analysis and interactive question and answer. In this process, a framework for applying knowledge graphs to research in the cultural field is summarized, providing ideas for research in the cultural field.
Biomechanical comparison of different suture anchors used in rotator cuff repair surgery–all‐suture anchors are equivalent to other suture anchors: a systematic review and network meta‐analysis
Authors: Yang Yi‐Shiuan , Shih Chien‐An , Fang Ching‐Ju , Huang Tzu‐Teng , Hsu Kai‐Lan , Kuan Fa‐Chuan , Su Wei‐Ren , Hong Chih‐Kai 
Published: April 2023

AbstractPurposeSuture anchors are commonly used to repair rotator cuff tendons in arthroscopy surgery, and several anchor materials have been created to maximize pull‐out strength and minimize iatrogenic damage. We hypothesized that all‐suture anchors have biomechanical properties equivalent to those of conventional anchors. Our purpose is to compare the biomechanical properties of different anchors used for rotator cuff repair.MethodsThe Embase, PubMed, Cochrane, and Scopus databases were searched for biomechanical studies on various suture anchors. The search keywords included rotator cuff tears and suture anchors, and two authors conducted study a selection, risk of bias assessment, and data extraction. The failure load, stiffness, and displacement were calculated using the mean differences with 95% confidence intervals (CIs). Failure modes were estimated using summary odds ratios with 95% CIs. The surface under the cumulative ranking curve was used for the relative ranking probabilities. A sensitivity analysis was performed by excluding studies using synthetic bones.ResultsThe polyetheretherketone (PEEK) (p < 0.001) and all‐suture anchors (p < 0.001) had higher failure loads than the biocomposite anchors, whereas no significant difference was observed in stiffness among the anchors. The all‐suture (p = 0.006) and biocomposite anchors (p < 0.001) had displacements higher than the metal anchors. The relative ranking of the included anchors in failure loads and displacement changed in sensitivity analysis. The meta‐analysis did not find significant differences, but the relative ranking probabilities suggested that all‐suture anchor had a higher rate of anchor pull‐out and a lower rate of eyelet or suture breakage. In contrast, the metal anchors were associated with a higher number of eyelet breakage episodes.ConclusionsAll‐suture anchors showed significantly higher failure loads than the biocomposite anchors and similar cyclic displacements to the biocomposite and PEEK anchors. There were no significant differences in stiffness between all‐suture and conventional suture anchors. The relative ranking of biomechanical properties changed in sensitivity analysis, suggesting the potential effect of bone marrow density.Level of EvidenceLevel IV.
Generalized topology and the family of monotonic maps $$\Gamma (X)$$
Authors: Kamel G. A. , Dib K. A. 
Published: April 2023

AbstractIn this paper, interesting properties of the generalized topological spaces, generated by the monotonic maps $$\sigma = (cl_{\delta }\circ int_{\delta }),$$

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Normalızatıon of masseter VEMP and comparıson wıth cervıcal VEMP ın normal ındıvıduals
Authors: Kılınç Ezgi , Gençtürk Ertuğrul , Taşcı Betül , Şerbetçioğlu Mustafa Bülent 
Published: April 2023

Abstract

Objectıve
The objective of this study is to obtain normative data of the masseter vestibular-evoked myogenic potential (mVEMP) test in healthy individuals without hearing loss and dizziness and to compare the responses with the cVEMP test.

Methods
Twenty healthy individuals (10 males and 10 females) aged 20–30 years without auditory and vestibular disorders participated in the study. First, mVEMP and then cVEMP tests were applied to the individuals who voluntarily participated in the study.

Results
Latency values of the air-conducted mVEMP were 15.90 ± 1.68 ms for P1 and 25.86 ± 1.48 ms for N1 and 9.96 ± 1.50 ms for interpeak latencies. P1N1 amplitude value was 97.89 ± 37.34 μV and asymmetry ratio (AR) was 0.13 ± 0.07. The normative data for the mVEMP threshold was found 84 dB nHL. According to the gender difference in mVEMP measurement parameters, the P1 latency of women was found shorter than the P1 latency of men at all stimulus intensities except 90 dB nHL. There was no statistically significant difference between mVEMP and cVEMP test results in all other severity and all parameters except P1 latency at 100 dB and interpeak latency at 100 dB (p > 0.05).

Conclusıon
In conclusion, it was the study findings suggest that obtaining normative data on mVEMP could be used as an auxiliary test in the evaluation of the vestibular and trigeminal pathway and the evaluation of patients with various peripheral and central vestibular disorders.