bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature‐Dependent Structures of Single‐Atom Catalysts
Authors: Chen Yuhui , Zhang Rui , Wang Hsiao‐Tsu , Lu Ying‐Rui , Huang Yu‐Cheng , Chuang Yu‐Chun , Wang Hua , Luo Jun , Han Lili 
Published: September 2023

AbstractSingle‐atom catalysts (SACs) have the unique coordination environment and electronic structure due to the quantum size effect, which plays an essential role in facilitating catalytic reactions. However, due to the limited understanding of the formation mechanism of single atoms, achieving the modulation of the local atomic structure of SACs is still difficult and challenging. Herein, we have prepared a series of Ni SACs loaded on nitrogen‐doped carbon substrates with different parameters using a dissolution‐and‐carbonization method to systematically investigate the effect of temperature on the structure of the SACs. The results of characterization and electrochemical measurements are analyzed to reveal the uniform law between temperature and the metal loading, bond length, coordination number, valence state and CO2 reduction performance, showing the feasibility of controlling the structure of SACs through temperature to regulate the catalytic performance. This is important for the understanding of catalytic reaction mechanisms and the design of efficient catalysts.
New Molecular Design, Step‐Saving Synthesis, and Applications of Indolocarbazole Core‐Based Oligo(hetero)arenes
Authors: Lin Li , Chiu Wei‐Hao , Cao Ming‐Ling , Lee Kun‐Mu , Yu Wei‐Lun , Liu Ching‐Yuan 
Published: September 2023

AbstractIn this work, we have successfully synthesized 15 new examples (LLA01‐06; LinLi01‐10) of small‐molecule hole‐transporting materials (HTM) using the less explored indolocarbazole (ICbz) as core moiety. Different from previously reported ICbz HTMs, LinLi01‐10 exhibit new molecular designs in which 3,4‐ethylenedioxythiophene (EDOT) units are inserted as crucial π‐spacers and fluorine atoms are introdcued into end‐group molecules. These substantially improve the materials solubility and device power conversion efficiencies (PCEs) while fabricated in perovskite solar cells (PSC). More importantly, LinLi01‐10 are generated by a sustainable synthetic approach involving the use of straightforward C−H/C−Br couplings as key transformations, thus avoiding additional synthetic transformations including halogenation and borylation reactions called substrate prefunctionalizations usually required in Suzuki reactions. Most HTM molecules can be purified simply by reprecipitations instead of conducting column chromatography. In contrast to LLA01‐06 without additional EDOT moieties, PSC devices using LinLi01‐10 as hole‐transport layers display promising PCEs of up to 17.5 %. Interestingly, PSC devices employing seven of the LinLi01‐10 as hole‐transport molecules, respectively, are all able to show an immediate >10 % PCE (t=0) without any device oxidation/aging process that is necessary for the commercial spiro‐OMeTAD based PSCs.
High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study
Authors: Wang Yonglu , Wang Fei , Kong Yue , Gao Tianshu , Zhu Qingyao , Han Lu , Sun Bei , Guan Luyang , Zhang Ziyi , Qian Yuxin , Xu Lingxi , Li Yun , Fang Hui , Jiao Gongkai , Ke Xiaoyan 
Published: September 2023

AbstractThe purpose of this study was to determine the effect of the Cz of high‐definition 5‐channel tDCS (HD‐tDCS) on social function in 4–12 years‐old children with autism spectrum disorder (ASD). This study was a randomized, double‐blind, pseudo‐controlled trial in which 45 ASD children were recruited and divided into three groups with sex, age, and rehabilitation treatment as control variables. Each group of 15 children with ASD was randomly administered active HD‐tDCS with the Cz as the central anode, active HD‐tDCS with the left dorsolateral prefrontal cortex (F3) as the central anode, and sham HD‐tDCS with the Cz as the central anode with 14 daily sessions in 3 weeks. The Social Responsiveness Scale Chinese Version (SRS‐Chinese Version) was compared 1 week after stimulation with values recorded 1 week prior to stimulation. At the end of treatment, both the anodal Cz and anodal left DLFPC tDCS decreased the measures of SRS‐Chinese Version. The total score of SRS‐Chinese Version decreased by 13.08%, social cognition decreased by 18.33%, and social communication decreased by 10.79%, which were significantly improved over the Cz central anode active stimulation group, especially in children with young age, and middle and low function. There was no significant change in the total score and subscale score of SRS‐Chinese Version over the Cz central anode sham stimulation group. In the F3 central anode active stimulation group, the total score of SRS‐Chinese Version decreased by 13%, autistic behavior decreased by 19.39%, and social communication decreased by 14.39%, which were all significantly improved. However, there was no significant difference in effect between the Cz and left DLPFC stimulation conditions. HD‐tDCS of the Cz central anode may be an effective treatment for social dysfunction in children with ASD.
A π‐Conjugated Porphyrin Complex as Cathode Material Allows Fast and Stable Energy Storage in Calcium Batteries
Authors: Smok Thomas , Shakouri Shirin , Abouzari‐Lotf Ebrahim , Pammer Frank , Diemant Thomas , Jana Saibal , Roy Ananyo , Xiu Yanlei , Klyatskaya Svetlana , Ruben Mario , Zhao‐Karger Zhirong , Fichtner Maximilian 
Published: September 2023

AbstractRechargeable calcium batteries (RCB) are prospective candidates for sustainable energy storage, as they hold the promise of the high energy density of lithium‐ion batteries (LIBs) while simultaneously combining it with highly abundant raw materials. However, for long time, calcium batteries have faced severe issues with regard to cycling stability, until recently developments demonstrated improved battery cycle life when employing CaSn alloy anodes with fluorinated alkoxyborate electrolytes. These findings opened up the possibility to study cathode materials for RCBs not only in a more comparable manner, but also in a practical full cell design. As representative of emerging organic electrode materials (OEMs), we investigated tetrakis(4‐pyridyl) porphyrin as both free ligand (H2TPyP) and in the form of its copper MOF complex (CuTPyP−MOF) as active cathode species in RCBs. The cells demonstrated high capacities and excellent cycling stability at the same time. Even at elevated current densities of e. g., 2000 mA/g the full cells delivered stable capacities of ~90 mAh/g proving its excellent rate capability. This study explores the electrochemical performance of porphyrin active materials in calcium batteries and represents a significant step forward in the progress toward organic electrodes for multivalent energy storage systems.
Ascorbic acid modulates immune responses through Jumonji‐C domain containing histone demethylases and Ten eleven translocation (TET) methylcytosine dioxygenase
Authors: Maity Jeet , Majumder Satyabrata , Pal Ranjana , Saha Bhaskar , Mukhopadhyay Prabir Kumar 
Published: September 2023

AbstractAscorbic acid is a redox regulator in many physiological processes. Besides its antioxidant activity, many intriguing functions of ascorbic acid in the expression of immunoregulatory genes have been suggested. Ascorbic acid acts as a co‐factor for the Fe+2‐containing α‐ketoglutarate‐dependent Jumonji‐C domain‐containing histone demethylases (JHDM) and Ten eleven translocation (TET) methylcytosine dioxygenasemediated epigenetic modulation. By influencing JHDM and TET, ascorbic acid facilitates the differentiation of double negative (CD4−CD8−) T cells to double positive (CD4+CD8+) T cells and of T‐helper cells to different effector subsets. Ascorbic acid modulates plasma cell differentiation and promotes early differentiation of hematopoietic stem cells (HSCs) to NK cells. These findings indicate that ascorbic acid plays a significant role in regulating both innate and adaptive immune cells, opening up new research areas in Immunonutrition. Being a water‐soluble vitamin and a safe micro‐nutrient, ascorbic acid can be used as an adjunct therapy for many disorders of the immune system.
Evolution of sex‐determination in dioecious plants: From active Y to X/A balance?
Authors: Kazama Yusuke , Kobayashi Taiki , Filatov Dmitry A. 
Published: September 2023

AbstractSex chromosomes in plants have been known for a century, but only recently have we begun to understand the mechanisms behind sex determination in dioecious plants. Here, we discuss evolution of sex determination, focusing on Silene latifolia, where evolution of separate sexes is consistent with the classic “two mutations” model—a loss of function male sterility mutation and a gain of function gynoecium suppression mutation, which turned an ancestral hermaphroditic population into separate males and females. Interestingly, the gynoecium suppression function in S. latifolia evolved via loss of function in at least two sex‐linked genes and works via gene dosage balance between sex‐linked, and autosomal genes. This system resembles X/A‐ratio‐based sex determination systems in Drosophila and Rumex, and could represent a steppingstone in the evolution of X/A‐ratio‐based sex determination from an active Y system.
Integrated continuous downstream process of monoclonal antibody developed by converting the batch platform process based on the process characterization
Authors: Konoike Fuminori , Taniguchi Masatoshi , Yamamoto Shuichi 
Published: September 2023

AbstractA continuous downstream process of monoclonal antibody was developed based on the process characterization. Periodic‐counter current chromatography (PCCC) with two protein A columns was used for the capture step. For low pH virus inactivation (VI), a batch reactor was employed, which can work as a surge (buffer) tank. Flow‐through chromatography (FTC) with two connected columns of different separation modes (anion‐mixed mode and cation exchange) was designed as a polish step. After 24 h PCCC run, the collected pool was processed for VI. After adjusting pH and electric conductivity, the solution was fed to the two connected FTC columns for 24 h. Virus filter was also connected to the exit of the connected‐column. PCCC and FTC were run in parallel. Six runs of different feed rates (0.5–10 L/day) and feed concentrations (1–3.2 g/L) were performed with protein A columns of 1–5 mL and FTC columns of 3–10 mL. The largest run (feed rate 10 L/day, feed concentration 2 g/L) was carried out at a GMP facility with 15 mL protein A columns and 100 mL FTC columns. Good recovery and purity values were obtained for all runs. The process was found to be flexible and stable for feed fluctuations. Only three surge or pool tanks were needed in addition to the final product pool tank.
Bioactive decellularized adipose matrix prepared using a rapid, nonchemical/enzymatic method for adipogenesis
Authors: Yang Jizhong , Tang Jiezhang , Dang Juanli , Rong Xiangke , Wang Kai , Zhang Zhaoxiang , Hou Mengmeng , Yu Zhou , Yi Chenggang 
Published: September 2023

AbstractRecent developments in the field of regenerative surgeries and medical applications have led to a renewed interest in adipose tissue‐enriched mesenchymal stem cell scaffolds. Various advantages declared for the decellularized adipose matrix (DAM) have caused its extensive use in the transfer of stem cells or growth factors for soft tissue regeneration induction. Meanwhile, the long‐term application of detergents toward DAM regeneration has been assumed as a risky obstacle in this era. Herein, a rapid, mechanical protocol was developed to prepare DAM (M‐DAM) without chemicals/enzymes and was comprehensively compared with the ordinary DAM (traditional chemical method). Accordingly, this method could effectively hinder oils and cells, sustain the structural and biological elements, and contain a superior level of collagen content. In addition, more protein numbers, as well as higher basement membrane elements, glycoproteins, and extracellular matrix‐related proteins were detected in the regenerated M‐DAM. Also, superior adipogenesis and angiogenesis proteins were distinguished. The noncytotoxicity of the M‐DAM was also approved, and a natural ecological niche was observed for the proliferation and differentiation of stem cells, confirming its great potential for vascularization and adipogenesis in vivo. The suggested technique could effectively prepare the modified DAM in variant constructions of tablets, powders, emulsions, hydrogels, and different three‐dimensional‐printed structures. Hence, this rapid, mechanical process can produce bioactive DAM, which has the potential to be widely used in various research fields of regenerative medicine.
Investigation of the photovoltaic effect in dye‐sensitized solar cells based on poly(ethylene glycol)‐nanofiber electrolytes
Authors: Kim Mi‐Ra , Park Sung Soo , Han Jeonghye , Pham Thanh Chung , Kang Minkyung , Lee Songyi 
Published: September 2023

AbstractIn this study, the effectiveness of electrospun poly(ethylene glycol) (PEG) nanofibers as polymer electrolytes for dye‐sensitized solar cells (DSSCs) is evaluated. Regular PEG nanofibers are electrospun at an applied voltage of 15 kV, using a polymer concentration of 13 wt% and tip‐to‐collector distance of 20 cm. Subsequently, the photovoltaic effect in DSSCs containing PEG‐nanofiber electrolytes with different I2 concentrations is analyzed. On reducing the concentration of I2 in the PEG‐nanofiber electrolyte, the short‐circuit photocurrent density (Jsc) of the corresponding DSSC increases significantly. A high power‐conversion efficiency of 5.93% is recorded (by a solar simulator under AM 1.5 illumination) for a PEG‐nanofiber‐based DSSC containing an I2/tetrabuthylammonium iodide (TBAI) molar ratio of 0.25. Additionally, electrochemical impedance spectroscopy is used to analyze the charge‐transfer resistance of the TiO2/PEG‐nanofiber electrolyte interface in the fabricated DSSCs; the electrolyte uptake, ionic conductivity, and charge‐transfer resistance values are investigated as a function of the molar ratio of I2/TBAI.
The involvement of language‐associated networks, tracts, and cortical regions in frontotemporal dementia and amyotrophic lateral sclerosis: Structural and functional alterations
Authors: Tahedl Marlene , Tan Ee Ling , Chipika Rangariroyashe H. , Lope Jasmin , Hengeveld Jennifer C. , Doherty Mark A. , McLaughlin Russell L. , Hardiman Orla , Hutchinson Siobhan , McKenna Mary Clare , Bede Peter 
Published: September 2023

AbstractBackgroundLanguage deficits are cardinal manifestations of some frontotemporal dementia (FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic lateral sclerosis (ALS). They have considerable social and quality‐of‐life implications, and adaptive strategies are challenging to implement. While the neuropsychological profiles of ALS–FTD phenotypes are well characterized, the neuronal underpinnings of language deficits are less well studied.MethodsA multiparametric, quantitative neuroimaging study was conducted to characterize the involvement of language‐associated networks, tracts, and cortical regions with a panel of structural, diffusivity, and functional magnetic resonance imaging (MRI) metrics. Seven study groups were evaluated along the ALS–FTD spectrum: healthy controls (HC), individuals with ALS without cognitive impairment (ALSnci), C9orf72‐negative ALS–FTD, C9orf72‐positive ALS–FTD, behavioral‐variant FTD (bvFTD), nonfluent variant primary progressive aphasia (nfvPPA), and semantic variant PPA (svPPA). The integrity of the Broca's area, Wernicke's area, frontal aslant tract (FAT), arcuate fascicle (AF), inferior occipitofrontal fascicle (IFO), inferior longitudinal fascicle (ILF), superior longitudinal fascicle (SLF), and uncinate fascicle (UF) was quantitatively evaluated. The functional connectivity (FC) between Broca's and Wernicke’ areas and FC along the FAT was also specifically assessed.ResultsPatients with nfvPPA and svPPA exhibit distinctive patterns of gray and white matter degeneration in language‐associated brain regions. Individuals with bvFTD exhibit Broca's area, right FAT, right IFO, and UF degeneration. The ALSnci group exhibits Broca's area atrophy and decreased FC along the FAT. Both ALS–FTD cohorts, irrespective of C9orf72 status, show bilateral FAT, AF, and IFO pathology. Interestingly, only C9orf72‐negative ALS–FTD patients exhibit bilateral uncinate and right ILF involvement, while C9orf72‐positive ALS–FTD patients do not.ConclusionsLanguage‐associated tracts and networks are not only affected in language‐variant FTD phenotypes but also in ALS and bvFTD. Language domains should be routinely assessed in ALS irrespective of the genotype.
Assessing the sustainable development of firms: The moderating role of transformational leadership and firm size
Authors: Rehman Nabeel , Majeed Nauman , Javaid Muhammad Umair , Arooj Azhar 
Published: September 2023

AbstractDue to escalating environmental problems and challenges, ensuring sustainable development (SD) has become a matter of concern for organizations worldwide at a precinct scale. This study aims to integrate the variables, which are antecedents of SD through direct and indirect paths. The managers as participants of small‐ and medium‐sized enterprises have helped the researchers to explore the role of green knowledge management (GKM) and green dynamic capacity with the intervention of green innovation and competitive advantage in achieving SD. The results achieved through structural equation modeling revealed positive and significant direct and indirect relationships, however, the intervening role of green innovation and green competitive advantage between GKM and SD show insignificant results. Interestingly, we have also identified two significant moderators as a part of this study: large firm size and transformational leadership. This research has important implications and significant contributions to theory and practice. It can be considered innovative by using a range of antecedents in an integrated way, proposing and testing a theoretical model of SD in a developing country Pakistan, which is affirmed and committed to achieving SDGs by the year 2030.
Sound conditioning strategy promoting paracellular permeability of the blood‐labyrinth‐barrier benefits inner ear drug delivery
Authors: Wang Xueling , Gu Jiayi , Xu Ke , Xu Baoying , Yu Dehong , Wu Hao 
Published: September 2023

AbstractThe therapeutic effects of pharmaceuticals depend on their drug concentrations in the cochlea. Efficient drug delivery from the systemic circulation into the inner ear is limited by the blood‐labyrinth‐barrier (BLB). This study investigated a novel noninvasive sound conditioning (SC) strategy (90 dB SPL, 8–16 kHz, 2 h sound exposure) to temporally enhance BLB permeability in a controllable way, contributing to maximizing the penetration of pharmaceuticals from blood circulation into the cochlea. Trafficking of Fluorescein Isothiocyanate conjugated dextran and bovine serum albumin (FITC‐dextran and FITC‐BSA) demonstrated that paracellular leakage of BLB sustained for 6 h after SC, providing a controllable time window for systemic administration. Cochlear concentrations of dexamethasone (DEX) and dexamethasone phosphate (DEX‐P), respectively transported by transcellular and paracellular pathways, showed a higher content of the latter one after SC, further confirming the key role of paracellular pathway in the SC‐induced hyperpermeability. Results of high‐throughput RNA‐sequencing identified a series of tight junction (TJ)‐associated genes after SC. The expressions of TJ (ZO‐1) were reduced and irregular rearrangements of the junction were observed by transmission electron microscopy after SC. We further determined the inhibiting role of Rab13 in the recruitment of ZO‐1 and later in the regulation of cellular permeability. Meanwhile, no significant change in the quantifications of endothelial caveolae vesicles after SC indicated that cellular transcytosis accounted little for the temporary hyperpermeability after SC. Based on these results, SC enhances the BLB permeability within 6 h and allows systemically applied drugs which tend to be transported by paracellular pathway to readily enter the inner ear, contributing to guiding the clinical medications on hearing loss.
Genome‐wide methylation profiling of diagnostic tumor specimens identified DNA methylation markers associated with metastasis among men with untreated localized prostate cancer
Authors: Chao Chun R. , Slezak Jeff , Siegmund Kimberly , Cannavale Kimberly , Shu Yu‐Hsiang , Chien Gary W. , Chen Xu‐Feng , Shi Feng , Song Nan , Van Den Eeden Stephen K. , Huang Jiaoti 
Published: September 2023

AbstractBackgroundWe used a genome‐wide discovery approach to identify methylation markers associated with metastasis in men with localized prostate cancer (PCa), as better identification of those at high risk of metastasis can inform treatment decision‐making.MethodsWe identified men with localized PCa at Kaiser Permanente California (January 1, 1997–December 31, 2006) who did not receive curative treatment and followed them for 10 years to determine metastasis status. Cases were chart review‐confirmed metastasis, and controls were matched using density sampling. We extracted DNA from the cancerous areas in the archived diagnostic tissue blocks. We used Illumina's Infinium MethylationEPIC BeadChip for methylation interrogation. We used conditional logistic regression and Bonferroni's correction to identify methylation markers associated with metastasis. In a separate validation cohort (2007), we evaluated the added predictive utility of the methylation score beyond clinical risk score.ResultsAmong 215 cases and 404 controls, 31 CpG sites were significantly associated with metastasis status. Adding the methylation score to the clinical risk score did not meaningfully improve the c‐statistic (0.80–0.81) in the validation cohort, though the score itself was statistically significant (p < 0.01). In the validation cohort, both clinical risk score alone and methylation marker score alone are well calibrated for predicted 10‐year metastasis risks. Adding the methylation score to the clinical risk score only marginally improved predictive risk calibration.ConclusionOur findings do not support the use of these markers to improve clinical risk prediction. The methylation markers identified may inform novel hypothesis in the roles of these genetic regions in metastasis development.