bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remdesivir associated sinus bradycardia in patients with COVID-19: A prospective longitudinal study
Authors: Hajimoradi Maryam , Sharif Kashani Babak , Dastan Farzaneh , Aghdasi Sina , Abedini Atefeh , Naghashzadeh Farah , Mohamadifar Arezoo , Keshmiri Mohammad Sadegh , Noorali Sima , Lookzadeh Somayeh , Alizadeh Niloufar , Siri Mohammad Amin , Tavasolpanahi Mohammadali , Abdolmohammadi Yazdan , Shafaghi Masoud , Rouhani Zahra Sadat , Shafaghi Shadi 
Published: January 2023

Background: Remdesivir is effective against SARS-Cov-2 with little evidence of its adverse effect on the cardiac system. The aim of the present study is investigating the incidence of bradycardia in COVID-19 patients treated with Remdesivir.Methods: This prospective longitudinal study was conducted in a tertiary center on COVID-19 patients for Remdesivir therapy. The objectives were to investigate the incidence of sinus bradycardia, and also the association between their demographics, underlying diseases, and the disease severity with developing bradycardia in COVID-19 patients treated with Remdesivir.Results: Of 177 patients, 44% were male. The mean (±standard deviation) age of patients was 49.79 ± 15.16 years old. Also, 33% were hospitalized due to more severe symptoms. Oxygen support was required for all hospitalized subjects. A total of 40% of the patients had comorbidities, with the most common comorbidity being hypertension. The overall incidence of bradycardia (heart rate&lt;60 bpm) in patients receiving Remdesivir was 27%, of whom 70% had extreme bradycardia (heart rate &lt;50 bpm). There was also a statistically significant reduction in heart rate after five doses of Remdesivir compared to the baseline heart rates. In the multivariable model, none of the covariates including age above 60 years, female sex, CRP&gt;50 mg/L, O2 saturation&lt;90%, underlying cardiovascular disease, hypertension and diabetes mellitus, and beta-blockers were associated with Remdesivir-induced bradycardia. No association was found between the COVID-19 severity indicators and bradycardia.Conclusion: As sinus bradycardia is a prevalent adverse cardiac effect of Remdesivir, it is recommended that all COVID-19 patients receiving Remdesivir, be evaluated for heart rate based on examination; and in the case of bradyarrhythmia, cardiac monitoring should be performed during administration to prevent adverse drug reactions.
Cross-cultural adaptation and psychometric evaluation of the Portuguese version of the family resilience questionnaire – short form (FaRE-SF-P) in women with breast cancer
Authors: Almeida Sílvia , Rodrigues da Silva Daniel , Frasquilho Diana , Costa Beatriz , Sousa Berta , Mourinho Baptista Telmo , Grácio Jaime , Lemos Raquel , Oliveira-Maia Albino J. 
Published: January 2023

BackgroundA diagnosis of cancer, and the resulting treatment process, can be perceived as a life-threatening event, affecting not only patients but also their social network and, more specifically, their relatives. While the ability to cope and adjust to difficult health situations may be challenging, family resilience may optimize a positive adaptation to adversity and contribute to enhance the patient’s quality of life. The Family Resilience Questionnaire (FaRE) is a self-report measure of family resilience that assesses this construct systematically. We aimed to validate the Portuguese version of a short form of the FaRE (FaRE-SF-P) in a sample of women with breast cancer.Methods147 women recently diagnosed with early breast cancer were recruited at the Champalimaud Clinical Centre in Lisbon. Participants completed psychometric assessment including the Portuguese version of the FaRE-SF-P, composed by two subscales of the original version – the FaRE Perceived Family Coping (FaRE-PFC) and the FaRE Communication and Cohesion (FaRE-CC). Confirmatory factor analysis (CFA) was performed to assess the factor structure of the FaRE-SF-P. Construct validity was assessed using the Hospital Anxiety and Depression Scale (HADS) for divergent validity, and the Modified Medical Outcomes Study Social Support Survey (mMOS-SS) as well as the social functioning subscale from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) for convergent validity.ResultsThe CFA results confirmed a correlated two-factor structure model consistent with the Perceived Family Coping and the Communication and Cohesion subscales. Internal consistency reliability indicated good values both for Perceived Family Coping and Communication and Cohesion subscales. The results for construct validity showed acceptable convergent and divergent validity.DiscussionThe FaRE-SF-P showed good psychometric properties demonstrating to be a valid and reliable family resilience measure to use in Portuguese women diagnosed with breast cancer. Since FaRE-SF-P is a short instrument it may be a useful screening tool in an oncological clinical practice routine.
Left-behind experience and language proficiency predict narrative abilities in the home language of Kam-speaking minority children in China
Authors: Yang Wenchun , Chan Angel , Gagarina Natalia 
Published: January 2023

IntroductionStudies have documented that child experiences such as external/environmental factors as well as internal factors jointly affect acquisition outcomes in child language. Thus far, the findings have been heavily skewed toward Indo-European languages and children in the Western, educated, industrialized, rich and democratic (WEIRD) societies. By contrast, this study features an understudied minority language Kam, and a group of so-called left-behind children in China growing up in a unique social-communicative environment.MethodsFifty-five bilingual children aged 5–9 acquiring Kam as home language were assessed using the Multilingual Assessment Instrument for Narratives (LITMUS MAIN). Twenty-three “two parents-left” children (mean age = 6;8, range: 5;0–9;2) remained in rural areas while both parents went to cities for employment, and they were raised by their grandparents. Thirty-two were “one parent-left” peers (mean age = 7;3, range: 5;0–9;3) who also resided in rural areas but were raised by one parent. Oral narrative texts were analysed for macrostructure based on story structure (SS), story complexity (SC) and internal state terms (IS). The study examined whether and how narrative production is predicted by internal factors such as chronological age and linguistic proficiency of a child and an external factor such as left-behind experience. Four measures were scored as outcome measures: SS, SC, IS type, IS token. Four measures were taken as predictors: chronological age, left-behind experience, scores in a lexical production task, and scores in a sentence repetition task tapping expressive morphosyntactic competence.ResultsResults showed that left-behind experience consistently predicted all four outcome measures, where the “two parents-left” children scored significantly lower than their “one parent-left” peers. Expressive vocabulary scores predicted three measures: SS, SC, and IS Token. Expressive morphosyntactic scores predicted SS and SC. Age, by contrast, did not predict any outcome measure.DiscussionThese findings suggested that being left-behind by both parents may be a negative prognostic indicator for the development and maintenance of heritage language abilities in ethnic minority children. We further discussed the conceptual significance of what it means for a child to be left-behind, by relating to more basic external factors in language development, including caregiver educational level, and amount of home language and literacy support by the caretakers.
Association between the risk of heart failure hospitalization and end-stage renal disease with digoxin usage in patients with cardiorenal syndrome: A population-based study
Authors: Chang Kai-Ting , Kuo Hsuan-Fu , Chang Yu-Han , Wang Yu-Tsang , Yang Lii-Jia , Niu Sheng-Wen , Kuo I-Ching , Chen Yumay , Wen Zhi-Hong , Hung Chi-Chih , Chang Jer-Ming , Lin Hugo Y.-H 
Published: January 2023

BackgroundThe management of the coexistence of heart disease and kidney disease is increasingly challenging for clinicians. Chronic kidney disease (CKD) is not only a prevalent comorbidity of patients with heart failure but has also been identified as a noteworthy risk factor for all-cause mortality and poor clinical outcomes. Digoxin is one of the commonest treatments for heart disease. There are few trials investigating the role of digoxin in patients with cardiorenal syndrome (CRS). This study aims to examine the association between digoxin usage and clinical outcomes in patients with CRS in a nationwide cohort.MethodWe conducted a population-based study that included 705 digoxin users with CRS; each patient was age, sex, comorbidities, and medications matched with three non-users who were randomly selected from the CRS population. Cox proportional hazards regression analysis was conducted to estimate the effects of digoxin on the incidence of all-cause mortality, congestive heart failure (CHF) hospitalization, coronary artery disease (CAD) hospitalization, and end-stage renal disease (ESRD).ResultsThe all-cause mortality rate was significantly higher in digoxin users than in non-users (adjusted hazard ratio [aHR] = 1.26; 95% confidence interval [CI] = 1.09–1.46, p = 0.002). In a subgroup analysis, there was significantly high mortality in the 0.26–0.75 defined daily dose (DDD) subgroup of digoxin users (aHR = 1.49; 95% CI = 1.23–1.82, p&lt;0.001). Thus, the p for trend was 0.013. With digoxin prescription, the CHF hospitalization was significantly higher [subdistribution HR (sHR) = 1.17; 95% CI = 1.05–1.30, p = 0.004], especially in the &gt;0.75 DDD subgroup (sHR = 1.19; 95% CI = 1.01–1.41, p = 0.046; p for trend = 0.006). The digoxin usage lowered the coronary artery disease (CAD) hospitalization in the &gt; 0.75 DDD subgroup (sHR = 0.79; 95% CI = 0.63–0.99, p = 0.048). In renal function progression, more patients with CRS entered ESRD with digoxin usage (sHR = 1.34; 95% CI = 1.16–1.54, p&lt;0.001). There was a significantly greater incidence of ESRD in the &lt; 0.26 DDD and 0.26–0.75 DDD subgroups of digoxin users (sHR = 1.32; 95% CI = 1.06–1.66, p = 0.015; sHR = 1.44; 95% CI = 1.18–1.75; p for trend&lt;0.001).ConclusionDigoxin should be prescribed with caution to patients with CRS.
Antibiotic Recommendations for Treatment of Canine Stromal Corneal Ulcers
Authors: Joksimovic Milan , Ford Bradley A. , Lazic Tatjana , Soldatovic Ivan , Luzetsky Sergey , Grozdanic Sinisa 
Published: January 2023

The aim of the study was to identify the aerobic bacterial isolates and determine corresponding antibiotic susceptibility profiles in vitro in canine clinical specimens with stromal corneal ulcers, with the goal of providing recommendations for first-line treatment with antibiotics. A total of 198 canine corneal stromal ulcer samples were studied between 2018 and 2021. A corneal swab was collected and cultured under aerobic conditions. Bacterial organisms were identified at the species level by MALDI-TOF mass spectrometry. Antibiotic susceptibility testing for commonly used topical and systemic antibiotics was performed by disk diffusion. Bacterial growth was obtained from 80% of samples. A variety of bacterial species were identified wherein the most common specimens were represented by Staphylococcus pseudintermedius (22%), Staphylococcus epidermidis (12%), Staphylococcus capitis (11%), and Pseudomonas aeruginosa (10%). Based on the overall antibiotic susceptibility data, neopolybac alone (96%) or a combination of neopolybac with either ofloxacin or amikacin (each 99%) showed the best coverage for commonly isolated bacterial organisms from canine corneal stromal ulcers. Results of this study support the use of the combined antibiotics as the first-line response for the treatment of canine corneal stromal ulcers. A statically significant increase in acquired bacterial resistance was detected during the longitudinal data observation.
PERANCANGAN DESAIN MOTIF BIOTA LAUT DENGAN KOMBINASI TEKNIK SHIBORI DAN BATIK UNTUK BISANA ANAK
Authors: Suryatmi Suryatmi 
Published: January 2023

Eksplorasi shibotik sebagai salah satu cara untuk menciptakan kreasi dan karya yang menarik pada kain. Shibotik adalah sebuah teknik membuat ragam hias dengan menggunakan teknik rintang warna dengan kombinasi teknik ikat, teknik jepit, teknik jahit dan teknik batik. Shibo adalah penggalan suku kata yang diambil dari Shibori (bahasa Jepang) yang merupakan sebuah teknik dalam membuat ragam hias dengan cara melipat, mengikat,menjahit dan juga menjepit. Sementara suku kata “tik” merupakan suku kata terakhir dari Shibo-tik, berasal dari penggalan suku kata terakhir dari Ba-tik.Batik merupakan salah satu bentuk seni kuno yang adiluhung. Kebutuhan produk fashion dan tekstil terus berkembang sesuai dengan perjalanan kebutuhan manusia. Eksplorasi yang dilakukan menghasilkan teknik-teknik baru dalam menghasilkan keanekaragaman produk tekstil dengan mengkombinasikan keberadaan sumber-sumber yang tersedia. Sumber ide biota laut digunakan untuk penciptaan motif batik sebagai bentuk edukasi untuk anak-anak yang dikombinasikan dengan teknik shibori dengan visualisasi yang lebih trendy dan modern sehingga menarik untuk diaplikasikan kedalam busana pesta anak dengan rentang usia 5-9 tahun serta sebagai bentuk inovasi dan kreatifitas penulis dalam menciptakan mode busana anak yang up to date guna melengkapi semua kebutuhan akan produk tekstil tersebut
Brand Equity Dalam Menghadapi Turbulensi Lingkungan
Authors: Maulvi Herzi Rahmatia , Dida Susanne , Setianti Yanti 
Published: January 2023

Brand merupakan unsur penting dalam kesuksesan sebuah bisnis. Semakin dikenal dan dikonsumi oleh khalayak, semakin tinggi kemungkinan ia menghasilkan profit yang tinggi. Keberhasilan suatu usaha sering kali ditentukan oleh kekuatan brand tersebut. Namun, meskipun perusahaan sudah melakukan serangkaian usaha terencana untuk membuat brandnya kuat, terkadang terjadi turbulensi lingkungan yang tidak diduga dan di luar dari kontrol perusahaan. Turbulensi ini dapat menimbulkan dampak negatif dan berpotensi mengancam kelancaran bisnis perusahaan dan tidak menutup kemungkinan dapat mempengaruhi posisi brand di pasar dan di masyarakat. Berdasarkan studi sebelumnya, brand equity disugestikan dapat menahan turbulensi lingkungan agar tidak berdampak pada brand. Penulisan ini menggunakan metode studi literatur dari berbagai sumber yakni buku, artikel ilmiah dan sumber dalam jaringan. Tujuan dari tulisan ini ialah untuk menganalisis bagaimana brand equity dapat mempertahankan brand dari turbulensi lingkungan.
Kata Kunci: Branding, ekuitas merek, turbulensi lingkungan
Kajian Unsur Visual pada Ilustrasi Sampul Novel ‘Cogheart: Rahasia Detak Jantung’
Authors: Ardian Ardiyani , Patria Asidigisianti Surya 
Published: January 2023

Sebuah novel membutuhkan beberapa aspek pendukung agar dapat bersaing dengan baik, seperti jalan cerita yang menarik, pengembangan tokoh yang jelas, dan sampul yang relevan dengan jalan cerita. Sampul bukan hanya sarana yang melindungi halaman buku, tapi juga sebagai wajah dari cerita tersebut. Cogheart merupakan serial novel bertema fantasi petualangan yang ditulis oleh Peter Bunzl, seorang novelis dan animator yang berasal dari London. Novel ini meraih popularitas tinggi dan mendapat penghargaan Sefton Super Reads Award 2017 dan Awesome Book Award 2018. Tujuan dari penelitian ini adalah untuk mendeskripsikan unsur-unsur visual dari sampul dan menganalisis keterkaitannya dengan isi cerita. Metode penelitian yang digunakan adalah deskriptif kualitatif. Penelitian ini menggunakan teori tinjauan desain untuk mendeskripsikan dan menjabarkan setiap elemen desain dalam sampul, yaitu: deskriptif, formalistik, interpretasi dan evaluasi. Hasil dari penelitian menunjukkan bahwa masing-masing elemen visual yang ada dalam novel mewakili tokoh, latar tempat, dan benda krusial yang ada di cerita novel. Penempatan elemen-elemen tersebut juga melambangkan jalan cerita yang tidak bisa ditebak.
Percancangan E-Katalog Kopi Khas Bandung Berbasis Website Guna Meningkatkan Kunjungan Wisatawan dan City Branding Kota Bandung Pasca Pandemi
Authors: Purbasari Sophia , Derry Midaya P G Guci 
Published: January 2023

Jawa Barat khususnya Bandung sebagai salah satu daerah penghasil kopi memiliki kopi khasnya sendiri. Keberagaman dari setiap jenis kopinya menjadi daya tarik tersendiri bagi para pecinta kopi. Setiap jenis kopinya tersebar di berbagai daerah di Bandung seperti Kopi Arjasari, Kopi Burangrang, Kopi Ciwidey, Kopi Gunung Halu, Kopi Gunung Tilu, Kopi Malabar, Kopi Manglayang, Kopi Palasari, dll. Sangat disayangkan di balik keberagamannya masih banyak yang belum mengetahui kopi khas Bandung khususnya bagi komunitas kopi dan umumnya pada masyarakat Bandung itu sendiri. Perancangan ini bertujuan untuk mengenalkan dan memberikan informasi mengenai kopi khas Bandung melalui media berupa e-katalog berbasis website. Dalam pengumpulan datanya perancangan ini menggunakan metode mix method, dengan melakukan wawancara dan membagikan kuisioner pada komunitas Nocturna.id. Hasil dari perancangan ini dapat dilihat bahwa media yang digunakan berkerja dengan cukup optimal, baik dalam segi akses, penyebaran dan jangkauan, sehingga efektif dalam mengenalkan informasi mengenai kopi khas Bandung.
Consolidation of Central Columns of Civil Multistory Structures to Increase the Critical Buckling Force
Authors: BOTIȘ Marius , PLEȘCAN Costel 
Published: January 2023

Civil multi-story structures are used as office buildings or residential buildings. The central pillars on the ground floor of the civil structures will have the largest gravitational load and implicitly will be the pillars most stressed in compression. In this paper, the authors propose to increase the critical buckling load of the central pillars on the ground floor in the event that it is necessary to strengthen these pillars, due to the change in the purpose of the building and the modification of the loads on the floors. To increase the buckling load in the case of these columns, it is proposed to increase the moment of inertia of the columns on the base region. To highlight how the critical loss of stability load changes, a theoretical model is made for the column with constant section and another for the column with variable section in steps. Finally, the results obtained for the critical load will be compared and it will be highlighted what is the increase in buckling load for the pole with variable section in relation to the pole with constant section.
Research on Heat Treatment Applied to High Strength Construction Steels
Authors: NEACȘU Marian-Iulian 
Published: January 2023

The paper presents the research carried out on a laboratory scale in order to establish the heat treatment parameters for the thick sheets used for naval constructions (welded joints). Investigations were carried out on steel sheets with two different chemical compositions.In the same cooling conditions, returns were made at different times and temperatures. For the different sheet thicknesses of 15, 20, 22 and 24 mm, various heat treatment options were performed, by changing the cooling conditions of the sheets, respectively the cooling speeds, conditions that can be achieved in the industry.The laboratory results showed that the required values for the mechanical characteristics are obtained only by cooling in water under pressure followed by a return at temperatures equal to or greater than 650 °C, a time greater than 70 min.
A Sensitivity Study of the Maximum Stress in a Rubber Circular Ring to the Coefficient of Friction Using FEM
Authors: BOAZU Doina 
Published: January 2023

The paper presents a sensitivity study of a rubber circular ring (O-Ring) depending on the value of the coefficient of friction (design parameter) between the ring and the surfaces between which it is mounted. The response value is the maximum von Mises stress in the rubber ring. The influence of temperature was not taken into account.Through this sensitivity nonlinear analysis using finite element modeling, the correlation between Equivalent maximum Von Mises Stress and Friction coefficient can be established, determining a maximum stress level of the rubber ring to the friction coefficient. This relationship is important for the preload stage of the gasket functioning.
The Influence of the Wear of the Refractory Lining, of the Tundish, on the Quality of the Steel
Authors: TUDOR Beatrice Daniela 
Published: January 2023

The quality of steel and continuously cast semi-finished products largely depend on the degree and control of the interaction between slag, gas, and refractories, with the steel melt. In this work, through the analysis of some samples from a used refractory lining of a tundish, with the help of optical microscopy, the wear of the refractory layer was highlighted, due to the erosion and infiltration of steel microparticles into the pores of the lining. The examination of the samples was carried out in the interface area, metal-shotcrete, shotcrete-concrete, and the area with refractory concrete.
Physico-Chemical Analysis of Drinking Water from the Town of Bârlad, Vaslui County
Authors: ISTRATE Gina Genoveva , PENIȘOARĂ Irina-Nicoleta 
Published: January 2023

The quality of drinking water was investigated in two localities from Vaslui county (Bârlad and Văleni) by comparison with a sample from Galați county. A number of parameters such as pH, turbidity, conductivity, nitrates, nitrites, temporary hardness, dissolved oxygen were analysed for each water sample collected during the month of May. The obtained values of each parameter were compared with the standard values set by the local standards, Law no. 458/2002 regarding the quality of drinking water.
Modified Thermosets – A Review
Authors: DRĂGHICI Sebastian Marian , DĂNĂILĂ ȚÎCĂU Irina , APARECI GÎRNEȚ Tamara , SĂRACU Gabriel , PĂDURARU Iulian , BRIA Vasile , CÎRCIUMARU Adrian , GOROVEI Mihaela-Claudia 
Published: January 2023

Recent and extensive reports on the development of preparation methods that can lead to obtaining various nanostructured polymeric materials, including the preparation of nanoparticles, nano-capsules, nano-gels, nano-fibres, dendrimers and nano-composites, have been presented in the literature to provide a picture of the complexity of the field, and the diversity of approaching methods. From the data presented by various researchers, it appears that by ensuring a rigorous control of the nano-structuration of polymers and/or by adding nano-particles to the polymer matrices, improvements in structural and functional properties can be achieved in a significant number of polymer systems as a response to the continuous demands of industrial advanced sectors. Until now, most of the studies on polymer blends have been related to the control of their physical and chemical properties, their barrier properties or their electrical conductivity. This paper briefly presents various applications of resins (thermoset polymers) used to synthesize some polymer materials and blends.
Experimental Determination of the Kuczynski Equation for the Case of CuSn12 Alloy Sintering
Authors: ALEXANDRU Petrică , ŞTEFĂNESCU Cristian 
Published: January 2023

Sintered copper-tin alloys are used to obtain products with numerous applications. Some bronze parts such as filters or bushings for self-lubricating bearings can only be produced by specific powder metallurgy technologies. Metal filters represent an important fraction in the field of sintered products. In the paper, measurements of the intergranular bridges were made on the samples obtained by sintering the spheroidal powder from the CuSn12 alloy. Free casting in graphite moulds followed by sintering was used (9 experiments, 3 temperatures x 3 durations). With these data, the coefficients from the Kuczinski equation were determined. Thus, the correlation between the desired porosity for a filter-type product (expressed by the size of the intergranular bridge) and the sintering technological parameters can be established.