bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrolyte‐Mediated Misconception of Carbon‐Based Electrode Performance and Beyond in Metal‐Ion Batteries
Authors: Wang Yuqi , Cao Zhen , Wahyudi Wandi , Ma Zheng , Liang Yao , Cavallo Luigi , Li Qian , Ming Jun 
Published: June 2023

AbstractA half‐cell that is composed of electrode and metal (e.g., lithium) is the most classical model for examining electrode performance in battery community, by which the voltage versus capacity profile is the important indicator. However, it is found that these results are not all reliable, as a misconception of electrode performance can be caused once the electrolyte is chemically unstable. As a paradigm, it is demonstrated that the diethyl carbonate (DEC) solvent can chemically react with lithium metal to form insoluble and soluble by‐products, which can accumulate on the lithium anode to influence the lithium potential and/or migrate to the counter electrode to proceed with the uncompleted electrochemical reactions. The resultant voltage‐capacity profile cannot reflect the actual electrode performance, such as the lithium storing capability within the graphite. The reason for this phenomenon is elucidated based on solvation chemistry, particularly the mechanism of mitigating it by introducing ethylene carbonatesolvent to form new hydrogen bonds. The viewpoint is further verified by employing the full cell and also extended in sodium and potassium batteries. This study shows the necessity of discerning the reliability of electrode performance and also sheds light on the importance of designing a compatible electrolyte to examine electrode performance.
Further validation of craniosynostosis as a part of phenotypic spectrum of BCL11B‐related BAFopathy
Authors: Pande Shruti , Mascarenhas Selinda , Venkatraman Aishwarya , Bhat Vivekananda , Narayanan Dhanya Lakshmi , Siddiqui Shahyan , Bielas Stephanie , Girisha Katta Mohan , Shukla Anju 
Published: June 2023

AbstractHeterozygous disease‐causing variants in BCL11B are the basis of a rare neurodevelopmental syndrome with craniofacial and immunological involvement. Isolated craniosynostosis, without systemic or immunological findings, has been reported in one of the 17 individuals reported with this disorder till date. We report three additional individuals harboring de novo heterozygous frameshift variants, all lying in the exon 4 of BCL11B. All three individuals presented with the common findings of this disorder i.e. developmental delay, recurrent infections with immunologic abnormalities and facial dysmorphism. Notably, craniosynostosis of variable degree was seen in all three individuals. We, thus add to the evolving genotypes and phenotypes of BCL11B‐related BAFopathy and also review the clinical, genomic spectrum along with the underlying disease mechanisms of this disorder.
Transition Metal Catalysis in Living Cells: Progress, Challenges, and Novel Supramolecular Solutions
Authors: James Catriona C. , de Bruin Bas , Reek Joost N. H. 
Published: June 2023

AbstractThe importance of transition metal catalysis is exemplified by its wide range of applications, for example in the synthesis of chemicals, natural products, and pharmaceuticals. However, one relatively new application is for carrying out new‐to‐nature reactions inside living cells. The complex environment of a living cell is not welcoming to transition metal catalysts, as a diverse range of biological components have the potential to inhibit or deactivate the catalyst. Here we review the current progress in the field of transition metal catalysis, and evaluation of catalysis efficiency in living cells and under biological (relevant) conditions. Catalyst poisoning is a ubiquitous problem in this field, and we propose that future research into the development of physical and kinetic protection strategies may provide a route to improve the reactivity of catalysts in cells.
Direct Regioselective Dehydrogenation of α‐Substituted Cyclic Ketones
Authors: Schwengers Sebastian Armin , Gerosa Gabriela Guillermina , Amatov Tynchtyk , Yasukawa Naoki , Brunen Sebastian , Leutzsch Markus , Mitschke Benjamin , Shevchenko Grigory André , List Benjamin 
Published: June 2023

AbstractWe disclose a highly regioselective, catalytic one‐step dehydrogenation of α‐substituted cyclic ketones in the presence of 2,3‐dichlorobenzo‐5,6‐dicyano‐1,4‐benzoquinone (DDQ). The high regioselectivity originates from a phosphoric acid‐catalyzed enolization, selectively affording the thermodynamically preferred enol, followed by the subsequent oxidation event. Our method provides reliable access to several α‐aryl and α‐alkyl substituted α,β‐unsaturated ketones.
Particle interaction strengths modified by magnetic fields
Authors: Piccinelli Gabriella , Sánchez Angel , Jaber‐Urquiza Jorge 
Published: June 2023

AbstractMagnetic fields are everywhere in the Universe and in our everyday life and many processes are affected by their presence, generating a rich phenomenology that depends also on other possible external agents. We review here some results, both from our workgroup and from other research groups, about the effect of magnetic fields on particles interaction processes, focusing mainly on recent results, but without losing sight on early seminal works on this topic. A vast assortment of physical situations and of analytical and numerical approaches can be found in the literature in this subject, making the comparison between them not straightforward. Our aim is to focus attention on differences and similarities between the different situations and approaches, looking for a systematization scheme that could be predictive, once the role played by each physical ingredient could be understood. The main purpose of this work is to find some physical explanations of the ongoing processes.
The current status and trends of DNA extraction
Authors: Ye Xiaojun , Lei Bo 
Published: June 2023

AbstractDNA extraction, playing an irreplaceable role in molecular biology as it is an essential step prior to various downstream biological analyses. Thus, the accuracy and reliability of downstream research outcomes depend largely on upstream DNA extraction methodology. However, with the advancement of downstream DNA detection techniques, the development of corresponding DNA extraction methods is lagging behind. The most innovative DNA extraction techniques are silica‐ or magnetic‐based. Recent studies have demonstrated that plant fiber‐based adsorbents (PF‐BAs) have stronger DNA capturing ability than classic materials. Moreover, magnetic ionic liquid (MIL)‐based DNA extraction has gathered attention lately, and extrachromosomal circular DNA (eccDNA), cell‐free DNA (cfDNA), and microbial community DNA are current research hotspots. These require specific extraction methods, along with constant improvements in the way they are used. This review discusses the significance as well as the direction of innovation of DNA extraction methods to try to provide valuable references including current status and trends for DNA extraction.
SUMO2/3 promotes the progression and oxaliplatin resistance of colorectal cancer through facilitating the SUMOylation at Ku80‐K307
Authors: Feng Dan , He Jinsong , Yuan Min , Chen Qing , Zeng Xi , Zhou Qilin , Wu Jian , Han Bin 
Published: June 2023

AbstractColorectal cancer (CRC) is one of the most prevalent cancers worldwide and is typically treated with the FOLFOX regimen (folinic acid, 5‐fluorouracil, and oxaliplatin). However, oxaliplatin resistance remains a serious clinical problem. In the present study, we found that SUMO2/3 was overexpressed in CRC tissues and exogenous overexpression of SUMO2/3 promoted CRC cell proliferation, extension, and invasion and positively regulated the cell cycle. In contrast, SUMO2/3 gene knockdowns inhibited migration and repressed cell viability in vitro and in vivo. In addition, we found that SUMO2/3 was recruited to the cell nucleus and suppressed oxaliplatin‐induced apoptosis of CRC cells. Moreover, Ku80, a DNA‐binding protein essential for the repair of DNA double‐strand breaks, was confirmed to bind with SUMO2/3. Notably, Ku80 undergoes SUMOylation at K307 by SUMO2/3 and this correlated with apoptosis in CRC cells suffering oxaliplatin stress. Collectively, we found that SUMO2/3 plays a specific role in CRC tumorigenesis and acts through Ku80 SUMOylation which is linked with the development of CRC‐oxaliplatin resistance.
The relationship between corporate environmental, social, governance issues and corporate sustainability in the financial sector: A managerial perspective
Authors: Sideri Labrini 
Published: June 2023

AbstractThis paper investigates whether Hellenic financial institutions' commitment on environmental social and governance (ESG) issues has any relation with financial institutions' corporate sustainability. As a contribution to previous literature, the moderating role of managers' perception in the conceptual model is explored. A survey has been conducted to obtain data about the association of ESG commitment with sustainability literacy, sustainability reporting credibility, SDGs awareness, sustainability, and financial performance. Top managers from Greek financial institutions were reviewed via an online questionnaire, during the third wave of the pandemic. The results of inductive analysis provide evidence that the sample displays good reliability and internal consistency. Particularly, dichotomous variables demonstrate internal contingency, whereas liker‐scaled variables exhibit significant correlation. It seems that sustainable development and SDGs awareness are positively correlated with ESG commitment according, while business commitment to environmental issues is inversely proportional to the negative economic impact of the pandemic to corporate sustainability performance. Eventually, it turns out that ESG commitment does affect corporate sustainability on the areas of sustainability reporting credibility, SDGs awareness, sustainability, and financial performance.
Circular economy business models as pillars of sustainability: Where are we now, and where are we heading?
Authors: Hina Maryam , Chauhan Chetna , Sharma Rajat , Dhir Amandeep 
Published: June 2023

AbstractThe prior literature has discussed the benefits of the circular economy business model (CEBM) while working to streamline the environmental aspect, touching upon the social aspect and improving the economic aspect. These aspects have been widely recognised as pillars of sustainability. Thus, prior scholars have sought to identify the relationship between the CEBM and sustainability. However, the extant literature, which remains relatively nascent, has failed to clarify this linkage for each pillar of sustainability. To address this lacuna, we followed a systematic literature review (SLR) approach to determine the current state of research on the CEBM and sustainability. Our study identifies and presents the thematic foci in the prior literature, which highlight the linkages between the CEBM and the pillars of sustainability. These thematic foci include the CEBM and sustainability, the CEBM and the environmental dimension, the CEBM and the social dimension and the CEBM and the economic dimension. In addition, this SLR recognises various research gaps within each theme and offers actionable avenues for future research. We also propose a conceptual framework, rooted in social capital theory (SCT), that highlights the linkages between the CEBM and sustainability. Our findings reveal that research at the intersection of the CEBM and sustainability considers the CEBM an integral component of sustainability. We conclude by presenting our work's theoretical and practical implications, which can assist scholars and organisations to incorporate the pillars of sustainability within their CEBMs.
2D QSAR, Design, and in Silico Analysis of Thiophene‐Tethered Lactam Derivatives as Antimicrobial Agents
Authors: Natarajan Ramalakshmi , Sivaperuman Amuthalakshmi , Samuel Abiseik , Patel Dinesh Hansaram , Jain Nikhil , Veerappan Manigandan , Kumar Nikhil Kushal 
Published: June 2023

AbstractBackground: A very high rate of resistance causes health‐care‐associated and community‐acquired infections. E. coli is one of the nine pathogens of highest concern to most of the antibiotics and other class of antimicrobials. Objective: The objective of the present study is to develop novel thiophene derivatives using 2D QSAR and in silico approach for E. coli resistance. Methods: Substituted thiophene series reported by Nishu Singla et al., were taken for QSAR analysis. From the results, a set of 15 new compounds were designed. A complete in silico analysis has been done using PADEL, Autodock vina, Swiss ADME, Protox II software. Results: The designed compounds obey the Lipinski's rule of five and were known to have excellent inhibitory action (pIC50 values −0.87 to −1.46) which is similar to the most active compound of the data set (pIC50 −0.69) taken for the study. The bioavailability score (0.65) with no toxicity representing that the designed compounds are suitable for oral administration. Conclusion: The designed compounds are inactive for mutagenicity and cytotoxicity and ADMET studies states that these molecules are likely to be orally bioavailable and could be easily transported, diffused, and absorbed. So, the designed compounds will definitely serve as a lead antibacterial agent for E. coli resistance.
Promiscuous Enzymes for Residue‐Specific Peptide and Protein Late‐Stage Functionalization
Authors: Alexander Ashley K. , Elshahawi Sherif I. 
Published: June 2023

AbstractThe late‐stage functionalization of peptides and proteins holds significant promise for drug discovery and facilitates bioorthogonal chemistry. This selective functionalization leads to innovative advances in in vitro and in vivo biological research. However, it is a challenging endeavor to selectively target a certain amino acid or position in the presence of other residues containing reactive groups. Biocatalysis has emerged as a powerful tool for selective, efficient, and economical modifications of molecules. Enzymes that have the ability to modify multiple complex substrates or selectively install nonnative handles have wide applications. Herein, we highlight enzymes with broad substrate tolerance that have been demonstrated to modify a specific amino acid residue in simple or complex peptides and/or proteins at late‐stage. The different substrates accepted by these enzymes are mentioned together with the reported downstream bioorthogonal reactions that have benefited from the enzymatic selective modifications.
Construction of Octahydro‐4H‐cyclopenta[b]pyridin‐6‐one Skeletons using Pot, Atom, and Step Economy (PASE) Synthesis
Authors: Raju Silver , Ghosh Palash , Nayani Kiranmai , Prashanth Jupally , Sridhar Balasubramanian , Mainkar Prathama S. , Chandrasekhar Srivari 
Published: June 2023

AbstractCascade aza‐Piancatelli reaction and [3+3]/[4+2] cycloaddition reactions are carried out using the ideality principles of pot, atom, and step economy (PASE) synthesis. The reaction resulted in generation of octahydro‐4H‐cyclopenta[b]pyridin‐6‐one scaffolds. Moreover, octahydro‐5,7a‐epoxycyclopenta[cd]isoindol‐4‐one frameworks of gracilamine alkaloid and a novel decahydro‐1H‐dicyclopenta[cd,hi]isoindol‐6‐one were also realized in good yields with excellent regio‐ and diastereo‐selectivities.
2‐Benzamide Tellurenyl Iodides: Synthesis and Their Catalytic Role in CO2 Mitigation
Authors: Jain Saket , Batabyal Monojit , Thorat Raviraj Ananda , Choudhary Pratibha , Jha Raushan Kumar , Kumar Sangit 
Published: June 2023

AbstractBenzamide‐derived organochalcogens (chalcogen=S, Se, and Te) have shown promising interest in biological and synthetic chemistry. Ebselen molecule derived from benzamide moiety is the most studied organoselenium. However, its heavier congener organotellurium is under‐explored. Here, an efficient copper‐catalyzed atom economical synthetic method has been developed to synthesize 2‐phenyl‐benzamide tellurenyl iodides by inserting a tellurium atom into carbon‐iodine bond of 2‐iodobenzamides in one pot with 78–95 % yields. Further, the Lewis acidic nature of Te center and Lewis basic nature of nitrogen of the synthesized 2‐Iodo‐N‐(quinolin‐8‐yl)benzamide tellurenyl iodides enabled them as pre‐catalyst for the activation of epoxide with CO2 at 1 atm for the preparation of cyclic carbonates with TOF and TON values of 1447 h−1 and 4343, respectively, under solvent‐free conditions. In addition, 2‐iodo‐N‐(quinolin‐8‐yl)benzamide tellurenyl iodides have also been used as pre‐catalyst for activating anilines and CO2 to form a variety of 1,3‐diaryl ureas up to 95 % yield. The mechanistic investigation for CO2 mitigation is done by 125Te NMR and HRMS studies. It seems that the reaction proceeds via formation of catalytically active Te−N heterocycle, an ebtellur intermediate which is isolated and structurally characterized.
Effect of kerosene aromaticity as a solvent on bulk and interfacial properties of Brazilian heavy crude oil with high asphaltene content
Authors: Daza‐Barranco Lina M. , Duncke Angela C. P. , de Souza Mendes Paulo R. , Alvarado José G. , Pérez‐Gramatges Aurora 
Published: June 2023

AbstractThis study investigated the effect of solvent aromaticity on asphaltene stability and interfacial behaviour using typical diluted heavy oils, which better represent the chemical diversity of petroleum components than previous studies that used simple solvent mixtures with low asphaltene concentrations. A Brazilian crude with high viscosity and asphaltene content was diluted with two kerosenes, one containing only saturated compounds (KeS), and the other a saturates/aromatics mixture (KeSA) to maintain total aromaticity in the oil mixture upon dilution. Viscosity, asphaltene stability, interfacial tension, and elasticity of the oil mixtures were measured, and correlated with emulsion stability, regarding the differences in solvent aromaticity and aromatics/saturates ratio. The results showed that the different kerosene compositions affected bulk viscosity and asphaltene flocculation, but had a lesser effect on oil/brine interfacial tension due to the high asphaltene content in the diluted oil. The elastic modulus decreased at higher dilutions with KeS, while it remained consistent for KeSA mixtures, which supported the differences obtained in emulsion stability, at solvent concentrations within the optimal aromaticity ratio reported for simple solvent mixtures. Interfacial segregation of the aromatics in KeSA was also observed, which has not been reported in previous studies using complex solvents. These findings suggest that the trends reported with model oils, such as heptol with added asphaltenes, can also be applied to more realistic complex oil mixtures with higher asphaltene concentrations. Nevertheless, it was suggested that maintaining the aromatic content may not be enough to prevent asphaltene flocculation upon dilution, due to the concurrent increase in saturates.
Mechanistic Applications of Nonlinear Effects in First‐Row Transition‐Metal Catalytic Systems
Authors: Zhu Xiaotao , Li Yajun , Bao Hongli 
Published: June 2023

Comprehensive SummaryKnowledge of asymmetric catalytic reaction mechanism is very important for rational design and synthesis of new chiral catalysts or catalytic systems with high catalytic activity and stereoselectivity. The studies of nonlinear effect have attracted wide attentions as a simple and practical mechanistic tool to probe complex asymmetric catalytic reactions. This review documents the application of the study of nonlinear effects on how to reveal the mechanism in asymmetric catalytic reactions that were catalyzed by the first‐row transition‐metals in the last decade and gives a brief discussion on the different models of nonlinear effect.
Gynura Cusimba‐Derived Nitrogen‐Doped Carbon Dots/ZnO Nanocomposite: A Biocompatible Alternative for Detecting Latent Fingerprints
Authors: Upadhyay Phalguni , Raghavan Akshaya , Ayyappan Shanmuganathan Mohanraj Alias , Radhakrishnan Mydhili , Chakravarty Sumana , Ghosh Sutapa 
Published: June 2023

AbstractTo address the present need in forensic security perceptions, including the ability to detect latent fingerprints, designing and development of low‐cost fluorescent materials becomes inevitable. This work illustrates the preparation of ZnO and its nanocomposite, Zn−CD with nitrogen doped carbon dots (CD−GC) with all components being generated from a single natural precursor, “Gynura Cusimba”. Cell viability experiment carried out on HEK 293T cell line revealed that CD−GC, pure ZnO nanoparticles, and Zn−CD_0.8 were all biocompatible after being suitably evaluated by various analytical methods. Zn−CD_0.8 nanopowder was useful in detecting level 1–3 features of latent fingerprint developed on several substrates, which displayed good contrast and visibility. The work also highlights the application of Zn−CD_0.8 nanopowder for real time detection of latent fingerprints by demonstrating its use to identify aged fingerprints and those immersed in water. The results indicate that the potential of Zn−CD_0.8 to be a reasonably priced alternative to the existing commercial powders.
FMap: A fuzzy map for scheduling elephant flows throughjumping traveling salesman problemvariant towardsoftware‐defined networking‐baseddata center networks
Authors: Abdollahi Sahar , Asadi Hamid , Montazerolghaem Ahmadreza , Mazinani Sayyed Majid 
Published: June 2023

SummaryNowadays data center networks (DCNs) should handle the ever‐growing load generated by diverse applications. It particularly occurs under concurrent flow requests and so‐called mice flows (MFs): elephant flows (EFs) ratio. Concentrating on a binary vision over flow size classification (EF or MF) results in subsequent unpredicted load imbalance due to neglecting EF's distinctions including a wide range of sizes. As a result, some EFs might utilize a path owing qualities beyond the given EF's demands, while another EF with higher requirements is attending to use an over‐utilized path. This article proposes FMap, a fuzzy map for scheduling EFs through our proposed variant of traveling salesperson problem (TSP) toward DCNs. FMap represents a novel EF scheduling scheme that integrates flow prioritization and routing decisions under the event pf parallel incoming flows besides the cooperation of the controller and OpenFlow switches in software‐defined networking (SDN) paradigm. FMap adopts fuzzy inference process to overcome the vagueness over EF's resource allocation. Mainly, FMap proposes a new variant of TSP (optimized by genetic algorithm) which enables EF's group forwarding with a minimum cost. FMap reduces the total hop count of EFs through considering a single optimal path for delivering groups of EFs that contain a same tag (priority). The outstanding results represent a major improvement as compared with equal cost multiple path, Hedera, Sonoum, and Size‐KP‐PSO. Particularly, the results illustrate an outperforming by 3.76×, 0.21×, 0.15×, 0.03×, and 0.03× in terms of total hop count, EFs FCT, packet loss, goodput, and received packets as compared with Size‐KP‐PSO, respectively.