bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative and quantitative analysis of self-reported sensory issues in individuals with neurodevelopmental disorders
Authors: Wada Makoto , Hayashi Katsuya , Seino Kai , Ishii Naomi , Nawa Taemi , Nishimaki Kengo 
Published: February 2023

IntroductionIndividuals with neurodevelopmental disorders, such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and specific learning disorders (SLD) have various types of sensory characteristics.MethodsThis study investigated sensory issues in individuals with neurodevelopmental disorders using a web-based questionnaire for qualitative and quantitative analysis, categorized the contents of their three most distressful sensory issues, and evaluated their order of priority.ResultsAuditory problems were reported as the most distressing sensory issue among the participants. In addition to auditory problems, individuals with ASD frequently reported more tactile problems, and individuals with SLD reported more visual problems. Among the individual sensory issues, in addition to aversion to sudden, strong, or specific stimuli, some participants reported confusions regarding multiple stimuli presenting concurrently. Additionally, the sensory issues related to foods (i.e., taste) was relatively more common in the minor group.ConclusionThese results suggest that the diversity of sensory issues experienced should be carefully considered when aiding persons with neurodevelopmental disorders.
Impairment of GABA inhibition in insomnia disorders: Evidence from the peripheral blood system
Authors: Xiang Ting , Liao Jiwu , Cai Yixian , Fan Mei , Li Congrui , Zhang Xiaotao , Li Hongyao , Chen Yushan , Pan Jiyang 
Published: February 2023

AimTo explore the change characteristics and related factors of various indexes of GABAergic system in peripheral blood of patients with insomnia disorder.MethodsIn this study, a total of 30 patients who met the DSM-5 diagnostic criteria for insomnia disorder and 30 normal controls were included. All subjects had a structured clinical interview with the Brief International Neuropsychiatric Disorder Interview, and PSQI was used to evaluate the sleep status of the subjects. Enzyme-linked immunosorbent assay (ELISA) was used to detect serum γ-aminobutyric acid (GABA), and RT-PCR was used to detect GABAA receptor α1 and α2 subunit mRNA. All data were statistically analyzed using SPSS 23.0.ResultsCompared with the normal control group, the mRNA levels of GABAA receptor α1 and α2 subunits in the insomnia disorder group were significantly lower, but there was no significant difference in the serum GABA levels between the two groups. And in the insomnia disorder group, there was no significant correlation between the GABA levels and the mRNA expression levels of α1 and α2 subunits of GABAA receptors. Although no significant correlation was found between PSQI and serum levels of these two subunit mRNAs, its component factors sleep quality and sleep time were negatively correlated with GABAA receptor α1 subunit mRNA levels, and daytime function was inversely correlated with GABAA receptor α2 subunit mRNA levels.ConclusionThe inhibitory function of serum GABA in patients with insomnia may be impaired, and the decreased expression levels of GABAA receptor α1 and α2 subunit mRNA may become a reliable indicator of insomnia disorder.
Case report: Rapid symptom resolution of a mixed affective state with high-frequency repetitive transcranial magnetic stimulation
Authors: Beydler Emily M. , Katzell Lauren , Schmidt Lauren , Carr Brent R. , Holbert Richard C. 
Published: February 2023

IntroductionBipolar major depressive episodes with mixed features are diagnosed in patients who meet the full criteria for a major depressive episode exhibiting three additional concurrent symptoms of hypomania or mania. Up to half of patients with bipolar disorder experience mixed episodes, which are more likely to be treatment-refractory than pure depression or mania/hypomania alone.CaseWe present a 68-year-old female with Bipolar Type II Disorder with a four-month medication-refractory major depressive episode with mixed features referred for neuromodulation consultation. Previous failed medication trials over several years included lithium, valproate, lamotrigine, topiramate, and quetiapine. She had no history of treatment with neuromodulation. At the initial consultation, her baseline Montgomery-Asberg Depression Rating Scale (MADRS) was moderate in severity at 32. Her Young Mania Rating Scale (YMRS) was 22, with dysphoric hypomanic symptoms consisting of heightened irritability, verbosity and increased rate of speech, and decreased sleep. She declined electroconvulsive therapy but elected to receive repetitive transcranial magnetic stimulation (rTMS).InterventionsThe patient underwent repetitive transcranial magnetic stimulation (rTMS) with a Neuronetics NeuroStar system, receiving nine daily sessions over the left dorsolateral prefrontal cortex (DLPFC). Standard settings of 120% MT, 10 Hz (4 sec on, 26 sec off), and 3,000 pulses/session were used. Her acute symptoms showed a brisk response, and at the final treatment, her repeat MADRS was 2, and YMRS was 0. The patient reported feeling “great,” which she defined as feeling stable with minimal depression and hypomania for the first time in years.ConclusionMixed episodes present a treatment challenge given their limited treatment options and diminished responses. Previous research has shown decreased efficacy of lithium and antipsychotics in mixed episodes with dysphoric mood such as the episode our patient experienced. One open-label study of low-frequency right-sided rTMS showed promising results in patients with treatment-refractory depression with mixed features, but the role of rTMS in the management of these episodes is largely unexplored. Given the concern for potential manic mood switches, further investigation into the laterality, frequency, anatomical target, and efficacy of rTMS for bipolar major depressive episodes with mixed features is warranted.
Effectiveness of health literacy interventions on anxious and depressive symptomatology in primary health care: A systematic review and meta-analysis
Authors: Magallón-Botaya Rosa , Méndez-López Fátima , Oliván-Blázquez Bárbara , Carlos Silva-Aycaguer Luis , Lerma-Irureta David , Bartolomé-Moreno Cruz 
Published: February 2023

BackgroundAffective disorders are a debilitating and very prevalent problem throughout the world. Often these are associated with the onset of comorbidities or a consequence of chronic diseases. Anxiety and depression are associated with poor social and personal relationships, compromised health. We aimed to synthesize evidence from studies measuring the impact of a health literacy (HL) intervention on the improvement of affective disorders.MethodsFor this systematic review and meta-analysis, we searched PubMed/MEDLINE, Embase, Web of Science, Ibecs, Cuiden, Scielo, Science Direct and Dialnet for exclusively randomized controlled trial studies (RCTs) published between 1 Jan 2011, and 31 May 2022. The search terms employed were “health literacy,” “health knowledge,” “anxiety,” “anxiety disorder,” “depression,” “depressive disorder,” and “adult.” The risk of bias assessment was performed using the Cochrane Collaboration Revised Risk of Bias tool (RoB2). We conducted random-effects meta-analyses and explored heterogeneity using meta-regression and a stratified survey.ResultsOf 2,863 citations found through the initial screening, 350 records were screened by the title and abstract for their themes and relevance. Finally, nine studies complied with the inclusion criteria for the meta-analysis. 66.66% of studies (n = 6) were rated as having a low risk of bias and 33.33% (n = 3) were judged to raise some concerns. The health literacy interventions were associated with −1.378 reduction in depression and anxiety questionnaires scores [95% CI (−1.850, −0.906)]. Low mood disorder scores are associated with better mental health and wellbeing.ConclusionOur findings demonstrate that an HL intervention in relation to the symptoms associated with affective disorders improves the emotional state of patients in PHC, with a moderately positive effect in reducing depression and anxiety.
Factors of the policy process influencing Health in All Policies in local government: A scoping review
Authors: Lilly Kara , Kean Bridie , Hallett Jonathan , Robinson Suzanne , Selvey Linda A. 
Published: February 2023

ObjectivesThis review aimed to identify factors in the policymaking environment that influence a Health in all Policies approach in local government, how these vary across different municipal contexts, and the extent that theories of the policy process are applied.MethodsA scoping review was conducted to include sources published in English, between 2001 and 2021 in three databases, and assessed for inclusion by two blind reviewers.ResultsSixty-four sources were included. Sixteen factors of the policy process were identified, expanding on previously reported literature to include understanding and framing of health, use of evidence, policy priority, and influence of political ideology. Eleven sources applied or referred to theories of the policy process and few reported findings based on different local government contexts.ConclusionThere are a range of factors influencing a Health in All Policies approach in local government, although a limited understanding of how these differ across contexts. A theory-informed lens contributed to identifying a breadth of factors, although lack of explicit application of theories of the policy process in studies makes it difficult to ascertain meaningful synthesis of the interconnectedness of these factors.
Effectiveness of online caries management platform in children's caries prevention: A randomized controlled trial
Authors: Yan Siqi , Luo Song , Yang Xiaoxia , He Lidan , Chen Xinyi , Que Guoying 
Published: February 2023

PurposeTo construct an online caries management platform and evaluate its efficacy in children's caries prevention based on caries risk.MethodsThe study participants were second-grade pupils. The caries risk assessment tool (CAT) was used to grade caries risk for all participants, who were randomly divided into the experimental (114 pupils) and control (111 pupils) groups. The experimental group used the Internet for caries management, while the control group was managed by traditional lecturing in classroom. The caries status of each surface of the first permanent molars was recorded. The basic information and oral health knowledge, attitude, and behaviors of participants were collected by questionnaire. One year later, outcome data were collected. Pearson's chi-squared test was used to analyze the caries risk assessment items and oral health behaviors. The Mann-Whitney U-test was used to analyze the decayed-missing-filled surfaces (DMFS) index, plaque index, and scores of oral health knowledge and attitude. P &lt; 0.05 was considered statistically significant. This study was available on the website of Chinese Clinical Trials Register (No: MR-44-22-012947).ResultsAfter 1 year, the oral health knowledge score was improved by 20.58% (P &lt; 0.001) in the experimental group and 6.02% in the control group. The plaque index was improved by 49.60% (P &lt; 0.001) in the experimental group and 21.01% in the control group. The DMFS index increased in both groups but there were no significant differences (P = 0.608). The experimental group had a better improvement effect in caries risk assessment items than the control group, including “whether the frequency of eating sugary snacks or drinks between meals is more than 3 times/day” (P = 0.033) and the use of fluoridated toothpaste (P = 0.020). The experimental group was better than the control group in reported oral health behaviors, including frequency of eating sweets before sleep (P = 0.032), brushing time (P = 0.001), and the filled rate (proportion of FS in DMFS) of first permanent molars (P = 0.003).ConclusionsThe online caries management platform showed more advantages than traditional lecturing in improving oral health knowledge and behaviors (oral hygiene practice, sugar consumption behavior, and medical treatment behavior). This platform provides a reliable implementation path for the occurrence and continuous improvement of oral health-related behaviors.
Spatiotemporal trends in neonatal, infant, and child mortality (1990–2019) based on Bayesian spatiotemporal modeling
Authors: Wang Shaobin , Ren Zhoupeng , Liu Xianglong 
Published: February 2023

BackgroundNeonatal mortality rate (NMR), infant mortality rate (IMR), and child mortality rate (CMR) show a huge difference across countries, which has been posing challenges for public health policies and medical resource allocation.MethodsBayesian spatiotemporal model is applied to assess the detailed spatiotemporal evolution of NMR, IMR, and CMR from a global perspective. Panel data from 185 countries from 1990 to 2019 are collected.ResultsThe continuously decreasing trend of NMR, IMR, and CMR indicated a great improvement in neonatal, infant, and child mortality worldwide. Further, huge differences in the NMR, IMR, and CMR still exist across countries. In addition, the gap of NMR, IMR, and CMR across the countries presented a widening trend from the perspective of dispersion degree and kernel densities. The spatiotemporal heterogeneities demonstrated that the decline degree among these three indicators could be observed as CMR &gt; IMR &gt; NMR. Countries such as Brazil, Sweden, Libya, Myanmar, Thailand, Uzbekistan, Greece, and Zimbabwe showed the highest values of b1i, indicating a weaker downward trend compared to the overall downward trend in the world.ConclusionsThis study revealed the spatiotemporal patterns and trends in the levels and improvement of NMR, IMR, and CMR across countries. Further, NMR, IMR, and CMR show a continuously decreasing trend, but the differences in improvement degree present a widening trend across countries. This study provides further implications for policy in newborns, infants, and children's health to reduce health inequality worldwide.
Soft-body dynamics induces energy efficiency in undulatory swimming: A deep learning study
Authors: Li Guanda , Shintake Jun , Hayashibe Mitsuhiro 
Published: February 2023

Recently, soft robotics has gained considerable attention as it promises numerous applications thanks to unique features originating from the physical compliance of the robots. Biomimetic underwater robots are a promising application in soft robotics and are expected to achieve efficient swimming comparable to the real aquatic life in nature. However, the energy efficiency of soft robots of this type has not gained much attention and has been fully investigated previously. This paper presents a comparative study to verify the effect of soft-body dynamics on energy efficiency in underwater locomotion by comparing the swimming of soft and rigid snake robots. These robots have the same motor capacity, mass, and body dimensions while maintaining the same actuation degrees of freedom. Different gait patterns are explored using a controller based on grid search and the deep reinforcement learning controller to cover the large solution space for the actuation space. The quantitative analysis of the energy consumption of these gaits indicates that the soft snake robot consumed less energy to reach the same velocity as the rigid snake robot. When the robots swim at the same average velocity of 0.024 m/s, the required power for the soft-body robot is reduced by 80.4% compared to the rigid counterpart. The present study is expected to contribute to promoting a new research direction to emphasize the energy efficiency advantage of soft-body dynamics in robot design.
Charting the solar cycle
Authors: Chapman S. C. 
Published: February 2023

Sunspot records reveal that whilst the Sun has an approximately 11 year cycle of activity, no two cycles are of the same duration. Since this activity is a direct driver of space weather at Earth, this presents an operational challenge to quantifying space weather risk. We recently showed that the Hilbert transform of the sunspot record can be used to map the variable cycle length onto a regular “clock” where each cycle has the same duration in Hilbert analytic phase. Extreme geomagnetic storms rarely occur within the quiet part of the cycle which is a fixed interval of analytic phase on the clock; there is a clear active-quiet switch-off and quiet-active switch-on of activity. Here we show how the times of the switch-on/off can be determined directly from the sunspot time-series, without requiring a Hilbert transform. We propose a method-charting-that can be used to combine observations, and reports of societal impacts, to improve our understanding of space weather risk.
Cone-beam breast CT-guided surface location facilitates breast-conserving surgery in breast cancer patients with extensive calcifications: A pilot study
Authors: Sun Ya , He Ni , Ye Feng , Zhou Chunyan , Wu Yaopan , Xie Chuanmiao , Tang Jun 
Published: February 2023

BackgroundExtensive malignant-appearing calcifications have traditionally been considered a contraindication for breast-conserving surgery. The evaluation of calcifications largely depends on mammography, which is limited by tissue superimposition and is unable to reveal spatial information about extensive calcifications. Three-dimensional imaging modality is needed to reveal the architecture of extensive calcifications. In the present study, a novel cone-beam breast CT-guided surface location technique was investigated to facilitate breast-conserving surgery in breast cancer patients with extensive malignant breast calcifications.MethodsBiopsy-proved early breast cancer patients with extensive malignant-appearing breast calcifications were included. A patient will be considered suitable for breast-conserving surgery if the spatial segmental distribution of calcifications is found by 3D images of cone-beam breast CT. Then, the margins of the calcifications were located in contrast-enhanced cone-beam breast CT images. Next, skin markers were located using radiopaque materials, and cone-beam breast CT was reperformed to confirm the accuracy of surface location. During breast-conserving surgery, lumpectomy was performed according to the previous surface location, and an intraoperative specimen x-ray was applied to double-check that the entire lesion was removed. Margin assessment was made for both intraoperative frozen section and postoperative pathology examination.ResultsFrom May 2019 to Jun 2022, 11 eligible breast cancer patients in our institution were included. Breast-conserving surgery was performed successfully in all patients using the surface location approach mentioned before. All patients achieved negative margins and satisfied cosmetic results.ConclusionThis study proved the feasibility of cone-beam breast CT-guided surface location for facilitating breast-conserving surgery in breast cancer patients with extensive malignant breast calcifications.
Unruptured anterior Inferior cerebellar artery aneurysm following stereotactic irradiation for vestibular schwannoma: Case report and literature review
Authors: Lu Denghui , Ping Haoda , Wei Chen , Fang Wei , Zhang Yunze , Wu Yingxi , Xue Yafei , Wang Bao , Qu Yan , Zhao Tianzhi 
Published: February 2023

BackgroundThe clinical features and therapeutic measures of vestibular schwannoma (VS) radiation-related aneurysm (RRA) have not been well described. We reported the first VS RRA case admitted for acute anterior inferior cerebella artery (AICA) ischemic symptoms. Literature was reviewed to present the research fruits about VS RRAs, and some therapeutic advices were given.Materials and methodsA 54-year-old woman who had undergone GKS 10 years previously for a right VS was admitted to our hospital in 2018 because of sudden onset of severe vertigo and vomiting, accompanied with unsteady gait. During tumor resection, a dissecting aneurysm arose from the main trunk of AICA was encountered accidently within the tumor. The aneurysm was successfully treated with direct clip ligation, sparing the parent vessel. Data about this case were combined with those of other 11 radiation-related AICA aneurysm cases retrieved from the current literature. The following parameters were evaluated: Age, Sex, Diagnostic method, Location of aneurysm, Age of radiotherapy (Years)/Latency, Rupture, x-ray dosage, Type of radiotherapy, History of surgical resection of VS, Aneurysm Type, Morphology, Number, Treatment, Operative complications, Sequela, Outcome. VS RRAs mainly occurred in women (75%) with a median age of 62.5 years and were mainly located on AICA. Ruptured aneurysms accounted for 75.0% of the total cases. This paper reported the first VS case admitted with acute AICA ischemic symptoms. Cases with sacciform-like, irregular and fusiform-shaped aneurysms accounted for 50.0%, 25.0% and 25.0% of the total, respectively. After surgical treatment, 75.0% patients recovered, except for 3 patients who developed new ischemic consequence.ConclusionPatients should be informed of the risk of RRAs after receiving radiotherapy for VS. In these patients, RRAs should be suspected when subarachnoid hemorrhage or AICA ischemic symptoms occurred. Active intervention should be conducted considering the high instability and bleeding rate of VS RRAs.
The attitude-behaviour gap in biosecurity: Applying social theories to understand the relationships between commercial chicken farmers' attitudes and behaviours
Authors: Pao Hai-ni , Jackson Elizabeth , Yang Tsang-sung , Tsai Jyan-syung , Hwang Yi-ting , Sung Watson H. T. , Pfeiffer Dirk U. 
Published: February 2023

IntroductionTraditionally, it is believed that people's behaviours align with their attitudes; however, during COVID-19 pandemic, an attitude-behaviour gap in relation to preventive measures has been observed in recent studies. As such, the mixed-methods research was used to examine the relationships between farmers' biosecurity attitudes and behaviours in Taiwan's chicken industry based on the cognitive consistency theory.MethodsContent analysis of face-to-face interviews with 15 commercial chicken farmers identified their biosecurity responses to infectious disease threats.ResultsThe results indicated the mismatch of farmers' attitudes and behaviours towards specific biosecurity measures, in that they act differently than they think. The findings of the qualitative research allowed the research team to conduct the subsequent quantitative, confirmatory assessment to investigate the mismatch of farmers' attitudes and behaviours in 303 commercial broiler farmers. Survey data were analyzed to discover the relationships between farmers' attitudes and behaviours in relation to 29 biosecurity measures. The results show a mixed picture. The percentage of the farmers who had the attitude-behaviour gap towards 29 biosecurity measures ranged from 13.9 to 58.7%. Additionally, at the 5% significant level, there is an association between farmers' attitudes and behaviours for 12 biosecurity measures. In contrast, a significant association does not exist for the other 17 biosecurity measures. Specifically, out of the 17 biosecurity measures, the disconnection of farmers' attitudes and behaviours was observed in three specific biosecurity measures such as using a carcass storage area.DiscussionBased on a fairly large sample of farmers in Taiwan, this study confirms the existence of an attitude-behaviour gap in context and applies social theories to provide an in-depth understanding of how infectious diseases are managed in the animal health context. As the results demonstrate the necessity of tailoring biosecurity strategies to address the gap, it is time to reconsider the current approach by understanding farmers' real attitudes and behaviours in relation to biosecurity for the success of animal disease prevention and control at the farm level.