bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined optical line-of-sight and crosslink radiometric navigation for distributed deep-space systems
Authors: Casini Stefano , Turan Erdem , Cervone Angelo , Monna Bert , Visser Pieter 
Published: September 2023

AbstractThis manuscript aims to present and evaluate the applicability of combining optical line-of-sight (LoS) navigation with crosslink radiometric navigation for deep-space cruising distributed space systems. To do so, a set of four distributed space systems architectures is presented, and for each of those, the applicability of the combination is evaluated, comparing it to the baseline solutions, which are based on only optical navigation. The comparison is done by studying the performance in a circular heliocentric orbit in seven different time intervals (ranging from 2024 to 2032) and exploiting the observation of all the pairs of planets from Mercury to Saturn. The distance between spacecraft is kept around 200 km. Later, a NEA mission test case is generated in order to explore the applicability to a more realistic case. This analysis shows that the technique can also cope with a variable inter-satellite distance, and the best performance is obtained when the spacecraft get closer to each other.
Multimodal force and temperature tactile sensor based on a short-channel organic transistor with high sensitivity
Authors: Mascia Antonello , Spanu Andrea , Bonfiglio Annalisa , Cosseddu Piero 
Published: September 2023

AbstractIn this manuscript, we report on a novel architecture for the fabrication of highly sensitive multimodal tactile transducers, for the simultaneous detection of temperature and force. Such devices are based on a flexible Organic Charge Modulated Field Effect Transistor (OCMFET) coupled with a pyro/piezoelectric element, namely a commercial film of poly-vinylene difluoride (PVDF). The reduction of the channel length, obtained by employing a low-resolution vertical channel architecture, allowed to maximize the ratio between the sensing area and the transistor’s channel area, a technological approach that allows to considerably enhance both temperature and force sensitivity, while at the same time minimize the sensor’s dimensions. Thanks to the employment of a straightforward, up-scalable, and highly reproducible fabrication process, this solution represents an interesting alternative for all those applications requiring high-density, high-sensitivity sensors such as robotics and biomedical applications.
A study of dealing class imbalance problem with machine learning methods for code smell severity detection using PCA-based feature selection technique
Authors: Rao Rajwant Singh , Dewangan Seema , Mishra Alok , Gupta Manjari 
Published: September 2023

AbstractDetecting code smells may be highly helpful for reducing maintenance costs and raising source code quality. Code smells facilitate developers or researchers to understand several types of design flaws. Code smells with high severity can cause significant problems for the software and may cause challenges for the system's maintainability. It is quite essential to assess the severity of the code smells detected in software, as it prioritizes refactoring efforts. The class imbalance problem also further enhances the difficulties in code smell severity detection. In this study, four code smell severity datasets (Data class, God class, Feature envy, and Long method) are selected to detect code smell severity. In this work, an effort is made to address the issue of class imbalance, for which, the Synthetic Minority Oversampling Technique (SMOTE) class balancing technique is applied. Each dataset's relevant features are chosen using a feature selection technique based on principal component analysis. The severity of code smells is determined using five machine learning techniques: K-nearest neighbor, Random forest, Decision tree, Multi-layer Perceptron, and Logistic Regression. This study obtained the 0.99 severity accuracy score with the Random forest and Decision tree approach with the Long method code smell. The model's performance is compared based on its accuracy and three other performance measurements (Precision, Recall, and F-measure) to estimate severity classification models. The impact of performance is also compared and presented with and without applying SMOTE. The results obtained in the study are promising and can be beneficial for paving the way for further studies in this area.
Effectiveness of tuning an artificial intelligence algorithm for cerebral aneurysm diagnosis: a study of 10,000 consecutive cases
Authors: Kuwabara Masashi , Ikawa Fusao , Sakamoto Shigeyuki , Okazaki Takahito , Ishii Daizo , Hosogai Masahiro , Maeda Yuyo , Chiku Masaaki , Kitamura Naoyuki , Choppin Antoine , Takamiya Daisaku , Shimahara Yuki , Nakayama Takeo , Kurisu Kaoru , Horie Nobutaka 
Published: September 2023

AbstractDiagnostic image analysis for unruptured cerebral aneurysms using artificial intelligence has a very high sensitivity. However, further improvement is needed because of a relatively high number of false positives. This study aimed to confirm the clinical utility of tuning an artificial intelligence algorithm for cerebral aneurysm diagnosis. We extracted 10,000 magnetic resonance imaging scans of participants who underwent brain screening using the “Brain Dock” system. The sensitivity and false positives/case for aneurysm detection were compared before and after tuning the algorithm. The initial diagnosis included only cases for which feedback to the algorithm was provided. In the primary analysis, the sensitivity of aneurysm diagnosis decreased from 96.5 to 90% and the false positives/case improved from 2.06 to 0.99 after tuning the algorithm (P < 0.001). In the secondary analysis, the sensitivity of aneurysm diagnosis decreased from 98.8 to 94.6% and the false positives/case improved from 1.99 to 1.03 after tuning the algorithm (P < 0.001). The false positives/case reduced without a significant decrease in sensitivity. Using large clinical datasets, we demonstrated that by tuning the algorithm, we could significantly reduce false positives with a minimal decline in sensitivity.
Minimum number of inertial measurement units needed to identify significant variations in walk patterns of overweight individuals walking on irregular surfaces
Authors: Sikandar Tasriva , Rabbi Mohammad Fazle , Ghazali Kamarul Hawari , Altwijri Omar , Almijalli Mohammed , Ahamed Nizam Uddin 
Published: September 2023

AbstractGait data collection from overweight individuals walking on irregular surfaces is a challenging task that can be addressed using inertial measurement unit (IMU) sensors. However, it is unclear how many IMUs are needed, particularly when body attachment locations are not standardized. In this study, we analysed data collected from six body locations, including the torso, upper and lower limbs, to determine which locations exhibit significant variation across different real-world irregular surfaces. We then used deep learning method to verify whether the IMU data recorded from the identified body locations could classify walk patterns across the surfaces. Our results revealed two combinations of body locations, including the thigh and shank (i.e., the left and right shank, and the right thigh and right shank), from which IMU data should be collected to accurately classify walking patterns over real-world irregular surfaces (with classification accuracies of 97.24 and 95.87%, respectively). Our findings suggest that the identified numbers and locations of IMUs could potentially reduce the amount of data recorded and processed to develop a fall prevention system for overweight individuals.
MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response
Authors: Lin Danhong , Yu Jingwen , Lin Leweihua , Ou Qianying , Quan Huibiao 
Published: September 2023

AbstractLack of efficient insulin secretion from the pancreas can lead to impaired glucose tolerance (IGT), prediabetes, and diabetes. We have previously identified two IGT-associated single nucleotide polymorphisms (SNPs) rs62212118 and rs13052524 located at two overlapping genes: MRPS6 and SLC5A3. In this study, we show that MRPS6 but not SLC5A3 regulates glucose-stimulated insulin secretion (GSIS) in primary human β-cell and a mouse pancreatic insulinoma β-cell line. Data mining and biochemical studies reveal that MRPS6 is positively regulated by the mitochondrial unfolded protein response (UPRmt), but feedback inhibits UPRmt. Disruption of such feedback by MRPS6 knockdown causes UPRmt hyperactivation in high glucose conditions, hence elevated ROS levels, increased apoptosis, and impaired GSIS. Conversely, MRPS6 overexpression reduces UPRmt, mitigates high glucose-induced ROS levels and apoptosis, and enhances GSIS in an ATF5-dependent manner. Consistently, UPRmt up-regulation or down-regulation by modulating ATF5 expression is sufficient to decrease or increase GSIS. The negative role of UPRmt in GSIS is further supported by analysis of public transcriptomic data from murine islets. In all, our studies identify MRPS6 and UPRmt as novel modulators of GSIS and apoptosis in β-cells, contributing to our understanding of the molecular and cellular mechanisms of IGT, prediabetes, and diabetes.
Interaction between gestational plane of nutrition and lactation diet composition on lactation performance of Alpine goats of different parities
Authors: Ribeiro Luana P. S. , Patra Amlan Kumar , Puchala Ryszard , Merkel Roger C. , Goetsch Arthur Louis 
Published: September 2023

AbstractA study was conducted with 48 multiparous and 31 primiparous Alpine goats to determine the effects of different nutritional planes during gestation and lactation on feed intake, body weight, body condition score and mass index, blood constituent concentrations, and milk yield and composition. Two gestation supplement treatments (GS; Moderate versus High) were imposed for approximately 5.5 months and two lactation diets (LD; Moderate vs. High) within each GS were fed for 16 wk. The Moderate GS (14.2% crude protein; CP) was given at 1.125% body weight (BW; dry matter basis) and the High GS (16.2% CP) was consumed ad libitum, with alfalfa hay available free-choice to all animals. Moderate and High LD contained 16.0 and 16.9% CP and 34.7 and 30.4% neutral detergent fiber, respectively. Body weight (77.5 vs. 72.0 kg) and body condition score (BCS; 3.22 vs. 3.04) at 11 days before kidding were greater (P < 0.05) for High versus Moderate GS, but BW at kidding (62.6 and 64.9 kg; SEM = 1.32) and 3 days later (60.9 and 63.6 kg for Moderate and High GS, respectively; SEM = 1.32) was similar. Litter size (1.9 and 2.4; SEM = 0.59), kid birth weight (3.72 and 3.59 kg; SEM = 0.097), and litter weight (6.55 and 7.13 kg for Moderate and High GS, respectively; SEM = 0.316) were similar between GS diets. However, kid birth weight (3.44 and 3.87 kg; SEM = 0.096) and litter weight (6.23 and 7.46 kg; SEM = 0.364) were greater (P < 0.05) for multiparous versus primiparous goats. Dry matter intake during lactation was greater for Moderate than for High GS (P ≤ 0.051) in kg/day, % BW, and g/kg BW0.75. However, milk fat (3.81, 4.14, 3.85, and 3.77%; SEM = 0.132) and protein concentrations (2.49, 2.50, 2.47, and 2.49%; SEM = 0.047), and raw (2.22, 2.59, 2.39, and 2.45 kg; SEM = 0.173) and energy yields of milk (6.02, 7.42, 6.51, and 6.63 MJ/day for Moderate GS-Moderate LD, Moderate GS-High LD, High GS-Moderate LD, and High GS-High LD, respectively; SEM = 0.453) were not affected by GS, LD, or their interaction. Dry matter intake, milk and its component yields, and heat energy (MJ/day) were higher (P < 0.05) for does than for doelings, but BCS and milk protein and fat concentrations were lower (P < 0.05) for does. Blood nonesterified fatty acid concentration was not affected by any diets, but there was interaction (P < 0.05) between GS and LD for betahydroxybutyric acid concentration. In conclusion, minor to moderate magnitudes of difference in nutritional planes during gestation and lactation had little effect on reproductive and lactation performance, reflecting the considerable capacity of lactating dairy goats for compensatory changes such as feed intake and tissue mobilization and accretion.
Point-of-care testing with Xpert HPV for single-visit, screen-and-treat for cervical cancer prevention: a demonstration study in South Africa
Authors: Denny Lynette , Saidu Rakiya , Boa Rosalind , Mbatani Nomonde , Castor Delivette , Moodley Jennifer , Kuhn Louise 
Published: September 2023

AbstractHuman papillomavirus (HPV)-based screen-and-treat (SAT) is recommended but implementation presents operational challenges. We implemented HPV-SAT at a research site in Khayelitsha, South Africa, screening 3062 women aged 30–65 years (44% women living with HIV [WHIV]). All were screened using point-of-care Xpert HPV and almost all received their HPV results on the same day. HPV-positivity occurred in 41.5% of WHIV and 17.4% of women without HIV (WNoH) reducing to 26.2% in WHIV and 10.4% in WNoH applying treatment eligibility criteria based on high viral load in the channels detecting HPV16, 18, 45, 16, 18, 31, 33, 35, 52, 58. Among those eligible for treatment, 91.3% were considered suitable for ablative therapy, and 94.6% underwent thermal ablation on the same day, with no serious adverse events. Twelve months later, 39.0% of WHIV and 65.2% of WNoH treated with ablative therapy were clear of HPV. In women who were HPV-positive but ineligible for treatment, 19.1% and 12.9% had histologically-confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2+) at 12 months. SAT programs need to weigh trade-offs between overtreatment versus delayed or no treatment for women who test positive for HPV. Treatment modalities for precancerous lesions need to be improved.
Pre- and post-treatment evaluation of routine blood analysis in patients with attention deficit hyperactivity disorder and comparison with the healthy control group
Authors: Öz Erdoğan , Parlak Mehmet Emin , Kapıcı Yaşar , Balatacı Umut , Küçükkelepçe Osman , Kurt Fatma 
Published: September 2023

AbstractThis study aimed to examine potential disparities in hematologic inflammation parameters between children diagnosed with attention deficit hyperactivity disorder (ADHD) and their healthy counterparts and to determine whether atomoxetine treatment induced any alterations in inflammation indicators. This case–control study involved 43 children aged 6–13 years, 22 diagnosed with ADHD for the first time, and 21 healthy children. In all children, complete blood count and albumin, C-reactive protein (CRP), thyroid stimulating hormone (TSH), free thyroxine (free T4), folate, vitamin B12, aspartate aminotransferase (AST), alanine transaminase (ALT), creatinine and urea values were performed. Children with ADHD were started on atomoxetine treatment, and one month later, the blood test was repeated for those who commenced treatment. Neutrophil (p = 0.005), platelet (PLT) (p = 0.002), neutrophil/lymphocyte ratio (NLR) (p = 0.001), platelet/lymphocyte ratio (PLR) (p < 0.001), systemic immune /inflammation index (SII) (p < 0.001) and pan-immune-inflammation value (PIV) (p = 0.025) parameters were found to be significantly higher than the control group, while the lymphocyte value (p = 0.001) was found to be significantly lower. In those in the ADHD group, lymphocyte (p = 0.041) and albumin (p = 0.027) values increased significantly after treatment. The results of this study show the increase in inflammation in drug-naive ADHD patients and the partial improvement after treatment. However, there is a need to evaluate inflammation in larger samples after longer-term treatments and follow-ups.
Adaptation and Reliability of the Cinderella Story Retell Task in Canadian French Persons Without Brain Injury
Authors: Brisebois Amélie , Brambati Simona Maria , Jutras Claudie , Rochon Elizabeth , Leonard Carol , Zumbansen Anna , Anglade Carole , Marcotte Karine 
Published: September 2023

Purpose:
Main concept (MC) analysis is a well-documented method of discourse analysis in adults with and without brain injury. This study aims to develop a MC checklist that is culturally and linguistically adapted for Canadian French speakers and examine its reliability. We also documented microstructural properties and provide a normative reference in persons not brain injured (PNBIs).

Method:
Discourse samples from 43 PNBIs were collected. All participants completed the Cinderella story retell task twice. Manual transcription was performed for all samples. The 34 MCs for the Cinderella story retell task were adapted into Canadian French and used to score all transcripts. In addition, microstructural variables were extracted using Computerized Language Analysis (CLAN). Intraclass correlation coefficients were computed to assess interrater reliability for MC codes and microstructural variables. Test–retest reliability was assessed using intraclass correlations, Spearman's rho correlations, and the Wilcoxon signed-ranks test. Bland–Altman plots were used to examine the agreement of the discourse measures between the two sessions.

Results:
The MC checklist for the Cinderella story retell task adapted for Canadian French speakers is provided. Good-to-excellent interrater reliability was obtained for most MC codes; however, reliability ranged from poor to excellent for the “inaccurate and incomplete” code. Microstructural variables demonstrated excellent interrater reliability. Test–retest reliability ranged from poor to excellent for all variables, with the majority falling between moderate and excellent. Bland–Altman plots illustrated the limits of agreement between test and retest.

Conclusions:
This study provides the MC checklist for clinicians and researchers working with Canadian French speakers when assessing discourse with the Cinderella story retell task. It also addresses the gap in available psychometric data regarding test–retest reliability in PNBIs.

Supplemental Material:

https://doi.org/10.23641/asha.24171087
High genotype diversity and zoonotic potential of Enterocytozoon bieneusi in yaks (Bos grunniens) from Ganzi Tibetan Autonomous Prefecture, Sichuan Province
Authors: Yang Xin , Fan Ying-Ying , Yang Dan-Jiao , Huang Shuang , Wang Jun-Wei , Chen Xu , Zhang Min , Liu Yi-Wen , Li Qiang , Song Jun-Ke , Zhao Guang-Hui 
Published: September 2023

Enterocytozoon bieneusi is a common pathogen in humans and various animals, threatening the breeding industry and public health. However, there is limited information on the molecular characteristics of E. bieneusi in yaks, an economically important animal mainly domesticated in the Qinghai Tibet Plateau in China. In the present study, nested PCR targeting the ITS gene region was applied to investigate the positive rates and genetic diversity of E. bieneusi in 223 faecal samples of yaks from three locations in Ganzi Tibetan Autonomous Prefecture, Sichuan Province. The total positive rate of E. bieneusi was 23.8% (53/223). Significant differences in positive rates were identified among yaks from three locations (χ2 = 8.535, p = 0.014) and four age groups (χ2 = 17.259, p = 0.001), with the highest positive rates in yaks from Yajiang and aged < 6 months, respectively. Sequence analysis identified seven known (EbpC, LW1, LQ10, PigEBITS5, ESH-01, J and BEB4) and five novel (Ganzi1–5) ITS genotypes. Phylogenetic analysis showed eight genotypes (EbpC, LW1, LQ10, PigEBITS5, ESH-01, Ganzi1, Ganzi2 and Ganzi4) in group 1 and three genotypes (J, BEB4 and Ganzi3) in group 2, indicating high genotype diversity and zoonotic potential of E. bieneusi in yaks from Ganzi. Considering the increasing zoonotic genotypes in yaks in the present study compared with previous findings, interventions should be developed to reduce the potential transmission of E. bieneusi between humans and animals.
Photoinduced Alkylation of Diazines with N-(Acyloxy)phthalimides in the Presence of Triethylamine
Authors: Chiba Shunsuke , Guerrero Itziar , Tan Eugene Yew Kun , Liu Yuliang , Edwards Lee J. 
Published: September 2023

AbstractA photochemical protocol for the alkylation of diazines (pyrimidines, pyrazines, and pyridazines) with N-(acyloxy)phthalimides has been developed. The process is facilitated by the presence of triethylamine under irradiation with 427–390 nm light; this enables rapid cross-coupling reactions to construct a wide range of alkylated diazines.
Surgery and Anesthesia Preoperative “Virtual Huddle”: A Pilot Trial to Enhance Communication across the Drape
Authors: Goldhaber Nicole H. , Reeves J. Jeffery , Puri Dhruv , Berumen Jennifer A. , Tran Minh , Clay Brian J. , Longhurst Christopher A. , Fergerson Byron 
Published: September 2023

Abstract
Objectives Effective communication between surgeons and anesthesiologists is critical for high-quality, safe, and efficient perioperative patient care. Despite widespread implementation of surgical safety checklists and time-outs, ineffective team communication remains a leading cause of patient safety events in the operating room. To promote effective communication, we conducted a pilot trial of a “virtual huddle” between anesthesiologists and surgeons.
Methods Attending anesthesiologists and surgeons at an academic medical center were recruited by email to participate in this feasibility trial. An electronic health record-based smartphone application was utilized to create secure group chats among trial participants the day before a surgery. Text notifications connected a surgeon/anesthesiologist pair in order to introduce colleagues, facilitate a preoperative virtual huddle, and enable open-ended, text message-based communication. A 5-point Likert scale-based survey with a free-text component was used to evaluate the utility of the virtual huddle and usability of the electronic platform.
Results A total of 51 unique virtual huddles occurred between 16 surgeons and 12 anesthesiologists over 99 operations. All postintervention survey questions received a positive rating (range: 3.50/5.00–4.53/5.00) and the virtual huddle was considered to be easy to use (4.47/5.00), improve attending-to-attending communication (4.29/5.00), and improve patient care (4.22/5.00). There were no statistically significant differences in the ratings between surgery and anesthesia. In thematic analysis of qualitative survey results, Participants indicated the intervention was particularly useful in interdisciplinary relationship-building and reducing room turnover. The huddle was less useful for simple, routine cases or when participation was one sided.
Conclusion A preoperative virtual huddle may be a simple and effective intervention to improve communication and teamwork in the operating room. Further study and consideration of broader implementation is warranted.
Half Filleted Flap for Thumb Reconstruction A Case Report
Authors: Knajoor Dr. Roy. , Ramaswamy Dr. C.N. 
Published: September 2023

AbstractMajor injury to the hand is a difficult problem to treat. Even after best of care, it is often difficult to get the hand rehabilitated back to its full function. In an attempt to preserve all the full complements of the hand, one tends to preserve all the viable tissue even when the functional capability is irrepairably damaged. The end result is a stiff posts which interfere with the basic function of hand. By careful initial assessment of the injury this can be avoided. It is also possible to use viable tissue from damaged finger on to another finger, which is less damaged and whose functional capability is unaffected. Use of a filleted flap is one such method. A case is presented, where full complement of distal phalanx, nail complex and other soft tissues were predicled on the Proximal Filleted skin of Index finger to reconstruct the terminal phalanx of the thumb and the soft tissue of the Thumb web.