bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic activation of human cardiac fibroblasts in vitro attenuates the reversibility of the myofibroblast phenotype
Authors: Hall Caitlin , Law Jonathan P. , Reyat Jasmeet S. , Cumberland Max J. , Hang Shaun , Vo Nguyen T. N. , Raniga Kavita , Weston Chris J. , O’Shea Christopher , Townend Jonathan N. , Gehmlich Katja , Ferro Charles J. , Denning Chris , Pavlovic Davor 
Published: July 2023

AbstractActivation of cardiac fibroblasts and differentiation to myofibroblasts underlies development of pathological cardiac fibrosis, leading to arrhythmias and heart failure. Myofibroblasts are characterised by increased α-smooth muscle actin (α-SMA) fibre expression, secretion of collagens and changes in proliferation. Transforming growth factor-beta (TGF-β) and increased mechanical stress can initiate myofibroblast activation. Reversibility of the myofibroblast phenotype has been observed in murine cells but has not been explored in human cardiac fibroblasts. In this study, chronically activated adult primary human ventricular cardiac fibroblasts and human induced pluripotent stem cell derived cFbs (hiPSC-cFbs) were used to investigate the potential for reversal of the myofibroblast phenotype using either subculture on soft substrates or TGF-β receptor inhibition. Culture on softer plates (25 or 2 kPa Young’s modulus) did not alter proliferation or reduce expression of α-SMA and collagen 1. Similarly, culture of myofibroblasts in the presence of TGF-β inhibitor did not reverse myofibroblasts back to a quiescent phenotype. Chronically activated hiPSC-cFbs also showed attenuated response to TGF-β receptor inhibition and inability to reverse to quiescent fibroblast phenotype. Our data demonstrate substantial loss of TGF-β signalling plasticity as well as a loss of feedback from the surrounding mechanical environment in chronically activated human myofibroblasts.
Health costs of wildfire smoke to rise under climate change
Authors: Clarke Hamish , Cirulis Brett , Borchers-Arriagada Nicolas , Bradstock Ross , Price Owen , Penman Trent 
Published: July 2023

AbstractThe global health burden from wildfire smoke is expected to worsen under climate change, yet we lack quantitative estimates of the economic costs of increased mortality and hospital admissions for cardiovascular and respiratory conditions. Using a quantitative wildfire risk assessment framework and a 12-member climate model ensemble, we find a median increase in wildfire smoke health costs of 1–16% by 2070 across diverse landscapes in south-eastern Australia. Ensemble maximum cost increases (5–38%) often exceed abatements from fuel treatment, while costs decline moderately (0–7%) for the ensemble minimum. Unmitigated climate change will increase the health burden of wildfire smoke and undermine prescribed burning effectiveness.
Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity
Authors: Jiang Yuhan , Li Zhen , Sui Dexin , Sharma Gaurav , Wang Tianqi , MacRenaris Keith , Takahashi Hideki , Merz Kenneth , Hu Jian 
Published: July 2023

AbstractEngineering of transporters to alter substrate specificity as desired holds great potential for applications, including metabolic engineering. However, the lack of knowledge on molecular mechanisms of substrate specificity hinders designing effective strategies for transporter engineering. Here, we applied an integrated approach to rationally alter the substrate preference of ZIP8, a Zrt-/Irt-like protein (ZIP) metal transporter with multiple natural substrates, and uncovered the determinants of substrate specificity. By systematically replacing the differentially conserved residues with the counterparts in the zinc transporter ZIP4, we created a zinc-preferring quadruple variant (Q180H/E343H/C310A/N357H), which exhibited largely reduced transport activities towards Cd2+, Fe2+, and Mn2+ whereas increased activity toward Zn2+. Combined mutagenesis, modeling, covariance analysis, and computational studies revealed a conditional selectivity filter which functions only when the transporter adopts the outward-facing conformation. The demonstrated approach for transporter engineering and the gained knowledge about substrate specificity will facilitate engineering and mechanistic studies of other transporters.
Amyotrophic Lateral Sclerosis–Bulbar Dysfunction Index–Remote: Test–Retest and Interrater Reliability of Candidate Items
Authors: Bouvier Liziane , Green Jordan R. , Tapia Carolina Barnett , Tilton-Bolowsky Victoria , Maffei Marc F. , Fless Zuzana , Seaver Katie , Huynh Anna , Gutz Sarah E. , Martino Rosemary , Abrahao Agessandro , Berry James , Zinman Lorne , Yunusova Yana 
Published: July 2023

Purpose:
The primary aim of this study was to establish the reliability of candidate items as a step in the development of the Amyotrophic Lateral Sclerosis–Bulbar Dysfunction Index–Remote (ALS-BDI-Remote), a novel tool being developed for the detection and monitoring of bulbar signs and symptoms in remote settings.

Method:
The set of candidate items included 40 items covering three domains: cranial nerve examination, auditory-perceptual evaluation, and functional assessment. Forty-eight participants diagnosed with ALS and exhibiting a range of bulbar disease severity were included. Data collection for each participant took place on Zoom over three sessions. During Session 1, the participants were instructed to adjust their Zoom settings and to optimize their recording environment (e.g., lighting, background noise). Their cognition and eating were screened to determine their ability to follow instructions and their eligibility to perform the swallowing and chewing tasks. During Session 2, two speech-language pathologists (SLPs) administered the tool consecutively to determine the items' interrater reliability. During Session 3, one of the SLPs readministered the tool within 2 weeks of Session 1 to assess test–retest reliability. The reliability of each item was estimated using weighted kappa and the percentage of agreement. To be considered reliable, the items had to reach a threshold of 0.5 weighted kappa or 80% percentage agreement (if skewed distribution of the scores) for both interrater and test–retest reliability.

Results:
In total, 33 of the 40 candidate items reached the reliability cutoff for both reliability analyses. All assessment domains included reliable items. Items requiring very good visualization of structures or movements were generally less reliable.

Conclusions:
This study resulted in the selection of reliable items to be included in the next version of the ALS-BDI-Remote, which will undergo psychometric evaluation (reliability, validity, and responsiveness analyses). Additionally, the results contributed to our understanding of the remote administration of SLP assessments for telehealth applications.
Are Children Performing Better on the Digit Span Backward Task Than the Digit Span Forward Task? An Exploratory Analysis
Authors: Pham Theresa , Archibald Lisa M. D. 
Published: July 2023

Purpose:
This research note was motivated by community speech-language pathologists (SLPs) who have expressed concerns about how to interpret the unexpected observation of higher performance on the Digit Span Backward task than the Digit Span Forward task on the Test of Integrated Language and Literacy Skills (TILLS). We therefore conducted an exploratory analysis to examine the pattern of digit span performance in children to help clinicians interpret their findings.

Method:

We investigated performance on the Digit Span Forward and Digit Span Backward subtests using the TILLS normative sample (
N
= 1,262). Raw scores, standard scores, and percentile ranks were systematically compared. In addition, we were able to estimate span length (longest number of items that can be accurately recalled) for 69 participants and evaluated the relation between performance and span length.

Results:
Our exploratory analyses revealed that “better” performance on the backward than forward task was rare. Instead, the pattern that SLPs are reporting can be explained by three factors: (a) a statistical phenomenon exacerbating small differences, (b) comparing standard scores or percentile ranks instead of raw scores or span length, and (c) better backward scores can still mean longer forward span length.

Conclusions:
It is likely that community SLPs tended to report cases of better backward than forward recall because it is the more remarkable and interesting finding, leading to the perception that the pattern is common, when it is not. Overall, we caution clinicians against overinterpreting their own client's performance on the digit span tests.
Qualitative Analysis of the Experiences and Perspectives of Autistic Speech-Language Pathologists
Authors: Oates Morgan , Bean Allison 
Published: July 2023

Purpose:
Supporting autistic speech-language pathologists (SLPs) is critical to expanding diversity within the field of speech-language pathology. The purpose of this study is to better understand how autistic SLPs reconcile tensions between their personal and professional experiences and negotiate the intersection of these identities.

Method:
Five certified SLPs, each of whom had a formal autism diagnosis or self-identified as autistic, engaged in a one-on-one semistructured conversation. The recorded interviews were transcribed manually. Following grounded theory analysis, multiple levels of coding were performed to construct a theoretical interpretation of the data.

Results:
Four themes arose from the analysis. In the first, participants described their outlooks on their autistic identities and how these have changed over time. The second theme concerns interpersonal tensions and conflicts related to communication differences across neurotypes. In the third, participants reflected on the stigma and ableism they face in their careers, and concerns about disclosing their autistic identity in the workplace. The fourth comprised participants' neurodiversity-affirming approaches to clinical practice with autistic clients.

Conclusions:
This study represents a first step toward understanding the unique strengths of autistic SLPs and the challenges they face. They can be better supported throughout their education, training, and careers. Our field must embrace and promote the neurodiversity paradigm to truly support all our colleagues and clients.
A novel pulse multiplication circuit for reducing harmonic distortion of 12 pulse rectifiers in aircraft electrical power systems
Authors: Abdollahi Rohollah , Salemnia Ahmad , Abdolhosseini Morteza 
Published: July 2023

AbstractTo improve the performance and reduce the total harmonic distortion (THD) of the autotransformer 12‐pulse rectifier, a novel pulse multiplication circuit (PMC) based on two tapped inter‐phase reactors (TIPRs) is proposed to improve performance and reduce the THD of the autotransformer 12‐pulse rectifier. The proposed rectifier includes a phase‐shifting autotransformer based on a polygon connection, two 6‐pulse diode bridge rectifiers (DBRs), and a PMC. The novel PMC consists of two TIPRs (TIPR1 and TIPR2), an auxiliary single‐phase diode bridge (including four diodes D1 to D4), and two auxiliary diodes D21 and D22, which are connected directly to the output terminal of the DBRs (DBR1 and DBR2). The simulation and experimental results confirm the high capability of the proposed PMC to reduce the harmonic distortion of the input current, so that by using the proposed PMC, the input current is almost sinusoidal and the THD of the input current is less than 3%. Also, the results show that the proposed 12‐pulse rectifier meets the standard requirements of aircraft electrical systems (DO‐160G) without the need for any input and output filters.
An image encryption algorithm based on cascade chaotic map and DNA coding
Authors: Zheng Jiming , Bao Tianyu 
Published: July 2023

AbstractThe 2D‐Cascade‐Transeform‐Logistic‐Sine Map (2D‐CTLSM) with good randomness and large parameter chaos range is obtained by improving the Logistic and Sine map in a cascade manner. By combining the chaotic map with DNA coding, an efficient encryption algorithm based on a chaotic map with chunking dislocation and alternate row diffusion is designed. The shortcomings of zigzag itself are overcome by performing different zigzag transformations in chunks while combining DNA encoding to accomplish the diffusion operation. Due to the excellent properties of DNA encoding, the diffusion operation is performed by the DNA computation method with alternate row diffusion so that each value can complete the diffusion operation twice. The simulation experimental results and security analysis show that the algorithm can effectively resist various typical attacks, such as the information entropy is close to the expected value of 8, the correlation coefficient is close to 0, and the NPCR and UACI values can meet the critical value range, and so on. This is a safe and reliable image encryption algorithm.
Techno‐economic, environmental and risk analysis of coordinated electricity distribution and district heating networks with flexible energy resources
Authors: Mirzaei Mohammad Amin , Zare Kazem , Mohammadi‐Ivatloo Behnam , Marzband Mousa , Anvari‐Moghaddam Amjad 
Published: July 2023

AbstractDue to the strong dependence between electricity generation and heating supply and the need for optimal use of renewable energies to supply power and heat loads, it is essential to provide an integrated energy management structure for electricity and heating systems. This paper studies the techno‐economic and environmental aspects of a combined electricity distribution and district heating system by considering multi‐type flexible energy resources and the environmental and practical constraints of both networks. The integrated energy system (IES) is equipped with wind power plants, combined heat and power plants, gas boilers, heat pumps, multi‐energy storage systems, electric vehicle parking lots, and multi‐energy demand response, as well as the IES operator can take part in the energy market to supply thermal and electrical demands. Besides, a robust strategy is adopted to control the power price uncertainty in the day‐ahead scheduling of IES, where a robustness parameter is considered to adjust the risk level of scheduling. The numerical results show that technical and environmental constraints can significantly increase the operation cost of IES by 11.8% and 3.6%, respectively. In addition, multi‐type flexible resources can improve the operational flexibility of IES by 16.1%.
Sliding mode control of four‐leg inverters in a stand‐alone microgrid for unbalance, neutral to ground voltage, and harmonics compensation
Authors: Ayoubi Effat , Miveh Mohammad Reza , Ghadimi Ali Asghar , Bagheri Sajad , Koushki Masoud Mehrabi 
Published: July 2023

AbstractIn a stand‐alone microgrid, voltage control is an important issue to keep the grid balanced under unbalanced load conditions. The other important challenges in microgrids include handling the neutral to the ground voltage (NGV) as well as total harmonic distortion (THD) under its limits due to the IEEE standards. A four‐leg inverter is the best choice for a three‐phase transformerless inverter employed in a stand‐alone microgrid. To control the inverter, sliding mode control (SMC) is a well‐known nonlinear control system to handle unbalanced and nonlinear load conditions as it can provide high sinusoidal load voltage with high performance and fast dynamic response. This paper proposes an enhanced SMC control method for minimizing the NGV and THD in addition to compensating for unbalanced load voltage conditions simultaneously in a three‐phase four‐leg inverter. In order to verify the results of the proposed method, simulation results with MATLAB/Simulink are presented to confirm the effectiveness of the proposed SMC under various load conditions. The proposed method provided fast dynamic response and fixed switching frequency. Further, a significant reduction occurred in NGV and THD. The simulation results of this method compared with the MPC method indicated the better performance of the proposed method against the unbalanced and nonlinear various load conditions.
Imaging the warped dusty disk wind environment of SU Aurigae with MIRC-X
Authors: Labdon Aaron , Kraus Stefan , Davies Claire L. , Kreplin Alexander , Zarrilli Sebastian , Monnier John D. , Le Bouquin Jean-Baptiste , Anugu Narsireddy , Setterholm Benjamin , Gardner Tyler , Ennis Jacob , Lanthermann Cyprien , ten Brummelaar Theo , Schaefer Gail , Harries Tim J. 
Published: July 2023

Context. T Tauri stars are low-mass young stars whose disks provide the setting for planet formation, which is one of the most fundamental processes in astronomy. Yet the mechanisms of this are still poorly understood. SU Aurigae is a widely studied T Tauri star and here we present original state-of-the-art interferometric observations with better uv and baseline coverage than previous studies.
Aims. We aim to investigate the characteristics of the circumstellar material around SU Aur, and constrain the disk geometry, composition and inner dust rim structure.
Methods. The MIRC-X instrument at CHARA is a six-telescope optical beam combiner offering baselines up to 331 m. We undertook image reconstruction for model-independent analysis, and fitted geometric models such as Gaussian and ring distributions. Additionally, the fitting of radiative transfer models constrained the physical parameters of the disk.
Results. Image reconstruction reveals a highly inclined disk with a slight asymmetry consistent with inclination effects obscuring the inner disk rim through absorption of incident star light on the near side and thermal re-emission/scattering of the far side. Geometric models find that the underlying brightness distribution is best modelled as a Gaussian with a Full-Width Half-Maximum of 1.53 ± 0.01 mas at an inclination of 56.9 ± 0.4° and a minor axis position angle of 55.9 ± 0.5°. Radiative transfer modelling shows a flared disk with an inner radius at 0.16 au which implies a grain size of 0.14 μm assuming astronomical silicates and a scale height of 9.0 au at 100 au. In agreement with the literature, only the dusty disk wind successfully accounts for the near infrared excess by introducing dust above the mid-plane.
Conclusions. Our results confirm and provide better constraints than previous inner disk studies of SU Aurigae. We confirm the presence of a dusty disk wind in the cicumstellar environment, the strength of which is enhanced by a late infall event which also causes very strong misalignments between the inner and outer disks.
Mode coupling coefficients between the convective core and radiative envelope of γ Doradus and slowly pulsating B stars
Authors: Aerts C. , Mathis S. 
Published: July 2023

Context. Signatures of coupling between an inertial mode in the convective core and a gravito-inertial mode in the envelope have been found in four-year Kepler light curves of 16 rapidly rotating γ Doradus (γ Dor) stars. This makes it possible to obtain a measurement of the rotation frequency in their convective core. Despite their similar internal structure and available data, inertial modes have not yet been reported for slowly pulsating B (SPB) stars.
Aims. We aim to provide a numerical counterpart of the recently published theoretical expressions for the mode-coupling coefficients, ε and ε̃. These coefficients represent the two cases of a continuous and a discontinuous Brunt-Väisälä frequency profile at the core-envelope interface, respectively. We consider γ Dor and SPB stars to shed light on the difference between these two classes of intermediate-mass gravito-inertial mode pulsators in terms of core and envelope mode coupling.
Methods. We used asteroseismic forward models of two samples consisting of 26 SPB stars and 37 γ Dor stars to infer their numerical values of ε and ε̃. For both samples, we also computed: the linear correlation coefficients between ε or ε̃ and the near-core rotation frequency, the chemical gradient, the evolutionary stage, the convective core masses and radii, and the Schönberg-Chandrasekhar limiting mass representing the maximum mass of an inert helium core at central hydrogen exhaustion that can still withstand the pressure of the overlaying envelope.
Results. The asteroseismically inferred values of ε and ε̃ for the two samples are between 0.0 and 0.34. While ε is most strongly correlated with the near-core rotation frequency for γ Dor stars, the fractional radius of the convective core instead provides the tightest correlation for SPB stars. We find ε to decrease mildly as the stars evolve. For the SPB stars, ε and ε̃ have similar moderate correlations with respect to the core properties. For the γ Dor stars, ε̃ reveals systematically lower and often no correlation to the core properties; their ε is mainly determined by the near-core rotation frequency. The Schönberg-Chandrasekar limit is already surpassed by the more massive SPB stars, while none of the γ Dor stars have reached it yet.
Conclusions. Our asteroseismic results for the mode coupling support the theoretical interpretation and reveal that young, fast-rotating γ Dor stars are most suitable for undergoing couplings between inertial modes in the rotating convective core and gravito-inertial modes in the radiative envelope. The phenomenon has been found in 2.4% of such pulsators with detected period spacing patterns, whereas it has not been seen in any of the SPB stars so far.
A Novelty of Several Optimization Criteria Hybrid Energy Storage System and Power Management in EV Applications
Authors: Sankarananth S. , Santhosh Kumar G. , Kavitha G. 
Published: July 2023

The power management capabilities of hybrid energy storage systems offer several advantages for EVs, including improved performance, longer battery life, and reduced cost. HES technologies which combine Li-ion cells with ultra-capacitors (UC), are developing as just a possible alternative to the constraints of conventional ESS for conserving electricity. Lithium-ion batteries have a limited cycle life, meaning that they gradually degrade with each charge-discharge cycle. This can reduce the overall lifetime of the ESS and require more frequent replacements, adding to the cost and environmental impact of EVs. To circumvent those constraints, mixed battery packs combining battery technology as well as superconductors are being developed. To improve the design and control of hybrid energy storage systems for electric vehicles (EVs), a bi-level multi-objective framework has been proposed. A Bi-level multi-objective design and control framework, incorporating NSGA-II and fuzzy logic control, to obtain an optimal sized hybrid energy storage system and corresponding power management strategy. This dynamic and multi-objective architecture may achieve optimum solution hybrids battery bank as well as a matching significant power scheme one at a moment through integrating non-dominated sorting genetic and fuzzy logic control methods. To evaluate the effectiveness of the proposed bi-level multi-objective framework, Pareto optimal solutions of different hybrid energy storage systems are obtained. This approach can lead to significant improvements in the performance and efficiency of hybrid energy storage systems, making them more suitable for EVs and other applications that require high-performance energy storage solutions.
Index Terms—Batteries, ultra capacitors, recursive imprecise input, non – linear and non optimisation, and e – mobility