bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-resolution Transmission Spectroscopy of the Terrestrial Exoplanet GJ 486b
Authors: Ridden-Harper Andrew , Nugroho Stevanus K. , Flagg Laura , Jayawardhana Ray , Turner Jake D. , de Mooij Ernst , MacDonald Ryan , Deibert Emily , Tamura Motohide , Kotani Takayuki , Hirano Teruyuki , Kuzuhara Masayuki , Omiya Masashi , Kusakabe Nobuhiko 
Published: March 2023

Abstract
Terrestrial exoplanets orbiting M-dwarf stars are promising targets for transmission spectroscopy with existing or near-future instrumentation. The atmospheric composition of such rocky planets remains an open question, especially given the high X-ray and ultraviolet flux from their host M dwarfs that can drive atmospheric escape. The 1.3 R
⊕ exoplanet GJ 486b (T
eq ∼ 700 K), orbiting an M3.5 star, is expected to have one of the strongest transmission spectroscopy signals among known terrestrial exoplanets. We observed three transits of GJ 486b using three different high-resolution spectrographs: IRD on Subaru, IGRINS on Gemini-South, and SPIRou on the Canada–France–Hawai’i Telescope. We searched for atmospheric absorption from a wide variety of molecular species via the cross-correlation method, but did not detect any robust atmospheric signals. Nevertheless, our observations are sufficiently sensitive to rule out several clear atmospheric scenarios via injection and recovery tests, and extend comparative exoplanetology into the terrestrial regime. Our results suggest that GJ 486b does not possess a clear H2/He-dominated atmosphere, nor a clear 100% water-vapor atmosphere. Other secondary atmospheres with high mean molecular weights or H2/He-dominated atmospheres with clouds remain possible. Our findings provide further evidence suggesting that terrestrial planets orbiting M-dwarf stars may experience significant atmospheric loss.
The Missing Link between Black Holes in High-mass X-Ray Binaries and Gravitational-wave Sources: Observational Selection Effects
Authors: Liotine Camille , Zevin Michael , Berry Christopher P. L. , Doctor Zoheyr , Kalogera Vicky 
Published: March 2023

Abstract
There are few observed high-mass X-ray binaries (HMXBs) that harbor massive black holes (BHs), and none are likely to result in a binary black hole (BBH) that merges within a Hubble time; however, we know that massive merging BBHs exist from gravitational-wave (GW) observations. We investigate the role that X-ray and GW observational selection effects play in determining the properties of their respective detected binary populations. We find that, as a result of selection effects, detectable HMXBs and detectable BBHs form at different redshifts and metallicities, with detectable HMXBs forming at much lower redshifts and higher metallicities than detectable BBHs. We also find disparities in the mass distributions of these populations, with detectable merging BBH progenitors pulling to higher component masses relative to the full detectable HMXB population. Fewer than 3% of detectable HMXBs host BHs >35M
⊙ in our simulated populations. Furthermore, we find the probability that a detectable HMXB will merge as a BBH system within a Hubble time is ≃0.6%. Thus, it is unsurprising that no currently observed HMXB is predicted to form a merging BBH with high probability.
On the Origin of Dust Structures in Protoplanetary Disks: Constraints from the Rossby Wave Instability
Authors: Chang Eonho , Youdin Andrew N. , Krapp Leonardo 
Published: March 2023

Abstract
High-resolution submillimeter observations of protoplanetary disks with ALMA have revealed that dust rings are common in large, bright disks. The leading explanation for these structures is dust trapping in a local gas pressure maximum, caused by an embedded planet or other dynamical process. Independent of origin, such dust traps should be stable for many orbits to collect significant dust. However, ringlike perturbations in gas disks are also known to trigger the Rossby wave instability (RWI). We investigate whether axisymmetric pressure bumps can simultaneously trap dust and remain stable to the RWI. The answer depends on the thermodynamic properties of pressure bumps. For isothermal bumps, dust traps are RWI stable for widths from ∼1 to several gas scale heights. Adiabatic dust traps are stable over a smaller range of widths. For temperature bumps with no surface density component, however, all dust traps tend to be unstable. Smaller values of disk aspect ratio allow stable dust trapping at lower bump amplitudes and over a larger range of widths. We also report a new approximate criterion for RWI. Instability occurs when the radial oscillation frequency is ≲75% of the Keplerian frequency, which differs from the well-known Lovelace necessary (but not sufficient) criterion for instability. Our results can guide ALMA observations of molecular gas by constraining the resolution and sensitivity needed to identify the pressure bumps thought to be responsible for dust rings.
The Behavior of Bp Si Stars in the far-UV—Paper III: HD 112413
Authors: Monier Richard 
Published: March 2023

Abstract
The analysis of eleven spectra of the SiEuCr star HD 112413 recorded by the SWP camera on board the International Ultraviolet Explorer reveals variations of the far-ultraviolet spectral energy distribution over a time interval of three days and five hours. Large variations are present shortwards of 2000 Å which can be partly attributed to variations of the lines and continuum of Si ii. This confirms that silicon and iron-peak elements are not distributed in a uniform manner over the surface. The FUV variations occur in antiphase with the variations of the optical brightness which probably reflects redistribution of the FUV flux toward optical wavelengths as the star rotates.
Biodiversity of extant snails (Gastropoda, Mollusca) in the Pliocene Mountain Spur Natural Reserve (Northern Apennine, Italy)
Authors: Plazzi Federico , Pedroni Guido 
Published: March 2023

To date, there is a substantial lack of information about gastropods from the Tuscan-Emilian Apennine in the north of Italy, notwithstanding the availability of detailed and comprehensive literature on this molluscan class. We present a gastropod fauna from the Natural Reserve of the Pliocene Mountain Spur: to our knowledge, this is the first investigation of the extant gastropod fauna in the Tuscan-Emilian Apennine and one of the few in the Apennine's mountain chain as a whole.
We describe a gastropod fauna comprised by 25 species, belonging to 18 genera and 10 families: the general figure which is emerging is an assemblage of European and Mediterranean-European species, with a single Asian contribution. Several shells were collected as embedded in sandy-clayey soils and showed fossilisation traces: therefore, we regard these shells as subfossil samples. Namely, subfossil shells are from the species Pomatias elegans, Granaria frumentum, Retinella olivetorum, Xerolenta obvia obvia, Oxychilus cf. draparnaudi, Monacha cartusiana and Monacha cantiana. The present checklist is the first report in the Tuscan-Emilian Apennine and Emilia-Romagna areas for six taxa: Morlina glabra glabra, Oxychilius alliarius, Xerosecta cespitum, Fruticicola fruticum, Xerogyra spadae and Xerolenta obvia obvia.
Nine Years' Follow-up of Bilateral Extremely Low Vaulting of Implantable Collamer Lens: Case Report
Authors: Mechleb Nicole , Gatinel Damien , Saad Alain 
Published: March 2023

Purpose:
To present a patient with bilateral implantable Collamer lens (ICL) implantation with extremely low vault who was followed up over 9 years and in whom no cataract was detected.

Methods:
A 56-year-old woman underwent uneventful bilateral ICL implantation and her postoperative ICL vaulting was 10 and 8 µm in the right and left eye, respectively. After consultation with the patient, it was decided to withhold surgical intervention and follow up closely.

Results:
Nine years postoperatively, the patient had normal ophthalmological examination results: uncorrected distance and near visual acuity of 20/20, normal intraocular pressure and open angle, stable ICL with low vaulting of 8 to 12 µm, clear lens with stable Objective Scatter Index scores, and normal posterior segment.

Conclusions:
This case report shows that even though low ICL vault is a risk factor for cataract development, withholding surgical intervention should be considered depending on the patient's age, characteristics, and compliance with close follow-up.

[
Journal of Refractive Surgery Case Reports.
2023;3(1):e5–e9.]
Applying Data Mining in Graduates’ Employability
Authors: Mpia Héritier Nsenge , Mburu Lucy Waruguru , Mwendia Simon Nyaga 
Published: March 2023

Envisaging an adequate IT/IS solution that can mitigate the employability problems is imperative because nowadays there is a high rate of unemployed graduates. Thus, the main goal of this systematic literature review (SLR) was to explore the application of data mining techniques in modeling employability and see how those techniques have been applied and which factors/variables have been retained to be the most predictors or/and prescribers of employability. Data mining techniques have shown the ability to serve as decision support tools in predicting and even prescribing employability.
The review determined and analyzed the machine learning algorithms used in data mining to either predict or prescribe employability. This review used the PRISMA method to determine which studies from the existing literature to include as items for this SLR. Hence, 20 relevant studies, 16 of which are predicting employability and 4 of which are prescribing employability. These studies were selected from reliable databases: ScienceDirect, Springer, Wiley, IEEE Xplore, and Taylor and Francis. According to the results of this study, various data mining techniques can be used to predict and/or to prescribe employability. Furthermore, the variables/factors that predict and prescribe employability vary by country and the type of prediction or prescription conducted research. Nevertheless, all previous studies have relied more on skill as the main factor that predict and/or prescribe employability in developed countries and none studies have been conducted in unstable developing countries. Therefore, the need to conduct research on predicting or prescribing employability in such countries by trying to use contextual factors beyond skill as features.
Improved Methods for Automatic Facial Expression Recognition
Authors: Echoukairi Hassan , El Ghmary Mohamed , Ziani Said , Ouacha Ali 
Published: March 2023

Facial expressions constitute one of the most effective and instinctive methods that allow people to communicate their emotions and intentions. In this context, the both Machine Learning (ML) and Convolutional Neural Networks (CNNs) have been used for emotion recognition. Efficient recognition systems are required for good human-computer interaction. However, facial expression recognition is related to several methods that impact the performance of facial recognition systems. In this paper, we demonstrate a state-of-the-art of 65% accuracy on the FER2013 dataset by leveraging numerous techniques from recent research and we also proposed some new methods for improving accuracy by combining CNN architectures such as VGG-16 and Resnet-50 with auxiliary datasets such as JAFFE and CK. To predict emotions, we used a second approach based on geometric features and facial landmarks to calculate and transmit the feature vector to the SVM model. The results show that the ResNet50 model outperforms all other emotion prediction models in real time by maximizing.
Ruminococcus gnavus and Limosilactobacillus reuteri Regulate Reg3γ Expression through Multiple Pathways
Authors: Ramirez Zeni E , Surana Neeraj K 
Published: March 2023

Abstract
Epithelium-derived antimicrobial peptides represent an evolutionarily ancient defense mechanism against pathogens. Regenerating islet-derived protein 3 γ (Reg3γ), the archetypal intestinal antimicrobial peptide, is critical for maintaining host–microbe interactions. Expression of Reg3γ is known to be regulated by the microbiota through two different pathways, although it remains unknown whether specific Reg3γ-inducing bacteria act via one or both of these pathways. In recent work, we identified Ruminococcus gnavus and Limosilactobacillus reuteri as commensal bacteria able to induce Reg3g expression. In this study, we show these bacteria require myeloid differentiation primary response protein 88 and group 3 innate lymphoid cells for induction of Reg3γ in mice. Interestingly, we find that R. gnavus and L. reuteri suppress Reg3γ in the absence of either myeloid differentiation primary response protein 88 or group 3 innate lymphoid cells. In addition, we demonstrate that colonization by these bacteria is not required for induction of Reg3γ, which occurs several days after transient exposure to the organisms. Taken together, our findings highlight the complex mechanisms underlying microbial regulation of Reg3γ.
Small cell conversion complicated with hypertrophic pulmonary osteoarthropathy after targeted therapy for advanced EGFR-mutated lung adenocarcinoma: A case report
Authors: Zhang Sijia , Chen Leichong , Zhu Kuikui , Meng Rui 
Published: March 2023

ABSTRACT
In recent years, with the opening of the era of precision therapy, the treatment of patients with positive driver genes is a hot issue in global research. EGFR is the most common driver gene in NSCLC, with a positivity rate of 17%. Although targeted drugs for EGFR mutations can benefit this population with efficacy, target therapy resistance inevitably occurs. The presented case suggests that a patient with advanced lung adenocarcinoma with EGFR mutation who developed pathological-type conversion of small cell lung cancer complicated with the development of hypertropic pulmonary osteoarthropathy (HPOA) after 6 months of targeted therapy. This case demonstrates that early diagnosis of HPOA can predict the occurrence of target resistance and pathologic conversion in patients with positive driver genes, providing new clues for the clinical management of lung cancer.
Analysis of Varying Micrornas as a Novel Biomarker for Early Diagnosis of Preeclampsia: A Scoping Systematic Review of the Observational Study
Authors: Athif Zhafir Asyura Muhammad Mikail , Komariah Maria , Amirah Shakira , Faisal Emir G. , Maulana Sidik , Platini Hesti , Pahria Tuti 
Published: March 2023

Background:
Preeclampsia (PE) is a pregnancy-related syndrome with moderate mortality. Early diagnosis of the condition remains difficult, with the current diagnostic modalities being ineffective. The varying microRNAs (miRNAs) as a novel biomarker pose an alternative solution with their potential to be reviewed.

Methods:
This study follows the Preferred Reporting Item for Systematic Review and Meta-Analysis Extended for Scoping Review (PRISMA-ScR). PubMed/MEDLINE, CENTRAL/Cochrane, ProQuest, Science Direct, and Wiley Online Library were used for this review. We only include observational studies. A critical appraisal was assessed in this study using QUADAS-2.

Results:
We retrieved 30 observational studies fulfilling the set criteria. Data extracted were synthesized qualitatively based on miRNAs that are more prominent and their area-under-the-curve (AUC) values. In total, 109 distinct dysregulated miRNAs were identified in comparison to healthy controls, with 10 of them (mir-518b, mirR-155, mirR-155-5p, miR-122-5p, miR-517-5p, miR-520a-5p, miR-525-5p, miR-320a, miR-210, and miR-210-3p) being identified in two or more studies. A brief look at the results shows that 49 miRNAs are downregulated and 74 miRNAs are upregulated, though the fold change of the dysregulation in all studies is not available due to some studies opting for a visual representation of the differences using whisker plots, bar charts, and heat map diagrams to visualize the difference from the reference control.

Conclusions:
This study has analyzed the potential of varying miRNAs as potential diagnostic biomarkers and how they might be used in the future. Despite this, potent miRNAs identified should be more emphasized in future research to determine their applicability and connection with the pathogenesis.
Simulation-based Ultrasound Curriculum for Novice Clinicians to Assess Neonatal Endotracheal Tube Position
Authors: Huang Diana , Watkins Laura A. , Weinschreider James , Ghazi Ahmed , Wang Hongyue , Dadiz Rita 
Published: March 2023

Background:
To evaluate the efficacy of a simulation-based mastery curriculum to train clinicians with limited-to-no sonography experience how to use ultrasound (US) to assess neonatal endotracheal tube (ETT) positioning.

Methods:
In a single-centered, prospective, educational study, 29 neonatology clinicians participated in a simulation-based mastery curriculum composed of a didactic lecture, followed by a one-on-one simulation session using a newly designed, three-dimensional (3D) printed US phantom model of the neonatal trachea and aorta. After mastery training, clinicians were evaluated with a performance checklist on their skills obtaining US images and assessing ETT positioning in the US phantom model. They also completed pre- and postcurriculum knowledge assessment tests and self-assessment surveys. The data were analyzed using Wilcoxon signed rank tests and repeated measures analysis of variance.

Results:
The mean checklist score improved significantly during three attempts (mean difference: 2.6552; 95% confidence interval [CI]: 2.2578–3.0525; P < 0.0001). The mean time to perform US decreased significantly from the first to third attempt (mean difference: −1.8276 min; 95% CI: −3.3391 to − 0.3161; P = 0.0196). In addition, there was a significant improvement in median knowledge assessment scores (50% vs. 80%; P < 0.0001) and survey ratings on knowledge and self-efficacy (P < 0.0001).

Conclusion:
Clinicians with limited-to-no sonography experience demonstrated improved knowledge and skill acquisition in using US to assess ETT positioning through simulation-based mastery training. The use of 3D modeling enhances simulation experiences and optimizes the quality of training during limited opportunities to achieve procedural competency in a controlled environment before further application into the clinical setting.
Subacromial Content to Subacromial Space Ratio in Neutral Position of the Arm as Diagnostic Criteria of Subacromial Impingement Syndrome
Authors: Bacha Raham , Gilani Syed Amir , Hanif Asif , Manzoor Iqra 
Published: March 2023

Background:
Shoulder impingement syndrome is one of the main causes of shoulder disability of working-class individuals. Currently, dynamic sonography of the shoulder is the modality of choice for the evaluation of shoulder impingement syndrome. The ratio of subacromial contents (SAC) and subacromial space (SAS) in neutral arm position could be used as a diagnostic parameter for the subacromial impingement syndrome (SIS), especially in patients who have difficulties in the elevation of their shoulders due to pain. To use the SAC to SAS ratio as a sonographic criterion for the diagnosis of SIS.

Methods:
SAC and SAS of 772 shoulders were vertically measured in coronal view with linear transducer 7–14MHz of Toshiba Xario Prime ultrasound unit, while the patient arm was kept in the neutral position. The ratio of both the measurements was calculated, to be used as a diagnostic parameter of the SIS.

Results:
The mean SAS was 10.79 ± 1.94 mm and SAC was 7.65 ± 1.43 mm. SAC-to-SAS ratio for normal shoulders was a focused value with narrow standard deviation (0.66 ± 0.03). However, shoulder impingement is confirmed by any value falls out of the range of ratio for normal shoulders. Area under the curve at 95% confidence interval was 96%, while the sensitivity at 95% confidence interval was 99.25% (97.83%–99.85%), and specificity was 80.86% (76.48%–84.74%).

Conclusion:
SAC-to-SAS ratio in neutral arm position is a relatively more accurate sonographic technique for the diagnosis of SIS.
Role of Bronchoscopic Cytology in Diagnosis of Pulmonary Lesions
Authors: Kedige Anjali Rao , Dinesh Udipi Shastri 
Published: March 2023

Objectives:
Respiratory cytology specimens such as bronchoalveolar lavage (BAL) and bronchial wash (BW) obtained using a fiberoptic bronchoscope are very useful in detecting or ruling out various inflammatory conditions, infections, and neoplastic lesions. A study was carried out to determine the usefulness of respiratory cytology in the diagnosis of pulmonary lesions and the limitations of cytology if any, and correlate the results of cytology with biopsies wherever possible.

Methods:
All bronchoscopic cytology and biopsy specimens received at the pathology laboratory of this tertiary care institute between June 2014 and May 2017 were analyzed. Cytology smears were stained with Leishman's stain, hematoxylin and eosin (H and E), Papanicolaou (PAP), and Ziehl–Neelsen (ZN) stain for all cases and special stains wherever needed. Slides prepared from biopsy specimens were stained with H and E. Immunohistochemistry was used for confirmation and further typing of malignant lesions and diagnosis rendered was compared with the corresponding cytology diagnosis.

Results:
A total of 120 specimens of BAL or BW cytology with or without biopsy were analyzed. Thirty-three were diagnosed as non-specific inflammatory lesions. The most common malignancy diagnosed by cytology was adenocarcinoma followed by squamous cell carcinoma. Correlating BAL with biopsy specimens, the sensitivity, specificity, and diagnostic accuracy of BAL were 100%, 88.8%, and 91.6%, respectively. Correlating BW with biopsy specimens, the sensitivity, specificity, and diagnostic accuracy of BW were 85.6%, 85.6%, and 85.6%, respectively.

Conclusions:
Accurate diagnosis can be made from the examination of bronchoscopic cytology specimens in pulmonary inflammation, tuberculosis, fungal infections, and malignancies. Combining respiratory cytology with biopsy and ancillary techniques can aid in better subtyping of neoplastic lesions.
High-dose dual therapy versus bismuth-containing quadruple therapy for the treatment of helicobacter pylori infection: A meta-analysis of randomized controlled trials
Authors: Zhang Chong , Zhang Jun , Cheng Yu-Jie 
Published: March 2023

Background:

Helicobacter pylori (H. pylori) infection is one of the most important public health issues, and bismuth-containing quadruple therapy (BQT) is the first-line therapeutic option. This study aimed to compare the efficacy and safety of high-dose dual therapy (HDDT) and BQT in eradicating H. pylori.

Methods:
Randomized controlled trials (RCTs) were retrieved from Pubmed, Embase, and Cochrane Library to evaluate the effects of HDDT and BQT on H. pylori infection from 2002 to August 31, 2022 (last 20 years). A meta-analysis was conducted using Review Manager 5.4 and dichotomous data were estimated by the risk ratio (RR) and the 100% confidence interval (CI). A heterogeneity test and publication bias adjustment were carried out using Stata 12.0.

Results:
5604 participants from 14 RCTs were included in this meta-analysis. The eradication rates of H. pylori in the HDDT group and the BQT group were 87.46% and 85.70%, respectively. There was a bordered significant difference (RR = 1.02, 95% CI: 1.00 ~ 1.04, P = 0.03) in the intention-to-treat (ITT) analysis. Inconsistently, in per-protocol (PP) analysis, HDDT showed similar efficacy to BQT (89.97% vs 89.82%, RR = 1.00, 95% CI: 0.99 ~ 1.02, P = 0.67). HDDT showed fewer frequent adverse events than BQT (13.00% vs 31.05%, RR = 0.41, 95% CI: 0.33 ~0.50, P < 0.00001). After adjusting for publication bias, the tendency did not change (RR = 0.49, 95% CI: 0.44 ~ 0.55, P < 0.00001). The compliance of the HDDT group has no significant difference compared with the BQT group (95.88% vs 93.84%, RR = 1.01, 95% CI: 1.00 ~ 1.03, P = 0.14).

Conclusion:
HDDT achieved a non-inferiority eradication rate, fewer side effects, and similar compliance compared with BQT.