bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological Survivorship in Head and Neck Cancer
Authors: Lane Ciaran , Higgins Ryan C. , Goyal Neerav 
Published: December 2022

AbstractSurvivorship for head and neck cancer patients presents unique challenges related to the anatomic location of their disease. After treatment, patients often have functional impairments requiring additional care and support. In addition, patients may have psychological challenges managing the effect of the disease and treatment. Routine screening is recommended for the identification of psychological conditions. This article reviews the latest research on key psychological conditions associated with head and neck cancer. It discusses risk factors for the development of each condition and provides recommendations for the management of patients who may present with psychological concerns.
Effective work function of TiN films: Profound surface effect and controllable aging process
Authors: Zhuang Yuanyuan , Liu Yiqun , Xia Hui , Li Yuying , Li Xiang , Li Tianxin 
Published: December 2022

Titanium nitride (TiN), with its tunable work function, serves as an electrode metal in the scaling fin-type field-effect transistor and plays the key role for low threshold operation. Measuring the effective work function of thin TiN films is desirable for rapid evaluation before device fabrication. In this work, Kelvin probe force microscopy is applied to study the impact of various factors on the surface potential of TiN films with an uncertainty below 30 mV. By scraping and gauging the potential evolvement of TiN in different circumstances, it is revealed that the surface effect is the major obstacle to determine the work function of the as-deposited TiN. For thick films, the potential drops over 530 mV for a fresh TiN surface relative to that of an aged one. For TiN films thinner than 5 nm, the potential changes by 290 mV due to surface oxidation. This enables a quantitative assessment on the effective work function as well as the surface charge density of TiN films.
The use of periphrasis for the expression of aspect by Greek heritage speakers
Authors: Alexiadou Artemis , Rizou Vasiliki 
Published: December 2022

AbstractIn this paper, we examine the narrowing of register variation in the domain of verbal aspect in the production of aspect by two different age groups of Greek heritage speakers (HSs), adolescents and adults, which we compared to their monolingual peers. We first identify a previously undocumented case of register variation for the expression of perfective aspect in Greek. Both HSs and monolingual speakers have at their disposal synthetic and analytic forms, the latter built on the basis of light verbs, to express grammatical aspect, and specifically perfective aspect. While monolinguals make use of this alternation to signal register variation, with periphrastic constructions used in informal settings and in the oral mode, HSs behave differently. Both adolescent and adult HSs generalize periphrastic constructions across formal and informal communicative situations, thus showing a case of register variation narrowing. The fact that periphrastic constructions are associated with perfective aspect is due to aspect levelling: HSs overgeneralize the use of the perfective aspect.
Effect of AC interference on failure mechanism of zinc-rich epoxy coatings in alkaline environment
Authors: Yang Chao , Han Qing , Liu Haibo , Wang Yuanyuan , Liu Yanfeng , Yao Shupeng 
Published: December 2022

Abstract
In this paper, the failure mechanism of Zn-rich epoxy coating under the AC interference in alkaline environment was revealed based on EIS tests. Using X80 steel as matrix, the coated X80 sample was formed by hand-brushing coating with the thickness of 25 ± 5 μm determined by five-point test. The EIS curves of the coated X80 sample in 3 wt% NaOH solution with immersion time was studied under (no) AC interference, and the failure evolution mechanism of Zn-rich epoxy coating was established through the fitting parameters. The results showed that during the curing process of the Zn-rich epoxy coating, Zn reacted with O2 in the air to generate ZnO, which coated the surface of Zn particle to form the ZnO-Zn structure. In alkaline environment, ZnO dissolved to form Zn(OH)2, namely the activation process of Zn particles, which was inhibited by AC interference. Furthermore, the activated Zn particles reacted to form Zn(OH)2 in alkaline environment, that is, the electrochemical reaction process of activated Zn particles, which was significantly promoted by AC interference. In conclusion, the non-conductive Zn(OH)2 generated in alkaline environment under AC interference, together with un-activated ZnO, can not only isolate the electrical connection between activated Zn particles, but also cut off the cathodic protection between Zn and Fe. Meanwhile, the matrix Fe was passivated in alkaline environment, which weakened the wet binding force between Fe and epoxy coating, resulting in coating stripping.
Study on corrosion resistance of HAZ and TMAZ in friction stir welding joint of 7075 aluminum alloy by thermal simulation
Authors: Liu Jinqiu , Guo Fuqiang , Wang Tao , Duan Shuwei , Zou Yong 
Published: December 2022

Abstract
It is difficult to characterize the variation of corrosion resistance of the narrow areas in friction stir welding (FSW) joints due to the large temperature gradient. In this paper, the welding thermal simulation was performed to simulate the heat affected zone (HAZ) and thermo-mechanical affected zone (TMAZ) of the FSW 7075-T6 aluminum alloy, and the corrosion resistance and microstructure of the simulated samples were studied. Results show that the corrosion potential changes greatly under different thermal simulation temperatures. The pitting corrosion of the HAZ simulated samples presents two pitting potentials, but for the TMAZ simulated samples, two pitting potentials will gradually evolve to one pitting potential with the increase of the maximum temperature. The electrochemical impedance spectroscopy results show that the corrosion mechanism of the HAZ and TMAZ is completely inconsistent, which is related to the differences in precipitate and grain characteristics.
Generalized Lie symmetries and almost regular Lagrangians: a link between symmetry and dynamics
Authors: Speliotopoulos Achilles D 
Published: December 2022

Abstract
The generalized Lie symmetries of almost regular Lagrangians are studied, and their impact on the evolution of dynamical systems is determined. It is found that if the action has a generalized Lie symmetry, then the Lagrangian is necessarily singular; the converse is not true, as we show with a specific example. It is also found that the generalized Lie symmetry of the action is a Lie subgroup of the generalized Lie symmetry of the Euler–Lagrange equations of motion. The converse is once again not true, and there are systems for which the Euler–Lagrange equations of motion have a generalized Lie symmetry while the action does not, as we once again show through a specific example. Most importantly, it is shown that each generalized Lie symmetry of the action contributes one arbitrary function to the evolution of the dynamical system. The number of such symmetries gives a lower bound to the dimensionality of the family of curves emanating from any set of allowed initial data in the Lagrangian phase space. Moreover, if second- or higher-order Lagrangian constraints are introduced during the application of the Lagrangian constraint algorithm, these additional constraints could not have been due to the generalized Lie symmetry of the action.
Molecular dynamics simulation of ammonium ion removal by freezing concentration
Authors: Liu Min , Shi Qi , Sun Zhaoru 
Published: December 2022

Abstract
Ammonium wastewater is a serious and common water pollutant that can have harmful effects on the environment. Freeze concentration, as an energy-efficient and environmentally friendly method, is used to treat ammonium wastewater by ice-water phase transition. The simulation results show that most of the ions are retained in the liquidphase, and it is reported for the first time that the probability of NH4
+ (90%) remaining in the water is significantly higher than that of Cl− (67%). We have analyzed the influence of ions on ice/water structure from the perspective of structure and energy and explained the reason for the difference in the probability of NH4
+ and Cl− remaining in the liquid phase. We find that the coordination number (CN) of NH4
+ decreases from 6 to 4 when one NH4
+ permeates the ice layer, indicating that the first hydration layer of ammonium ions underwent significant reorganization during this period. In contrast, a similar reduction in CN was not observed during the entry of Cl− into the ice layer. Moreover, the hydration energy shows that NH4
+ prefers to stay in the liquid phase than in the ice phase because of the higher hydration energy difference compared with that of Cl−. The results of this work indicate that freeze concentration can efficiently remove NH4
+ by ice-water phase transition, which greatly reduces the discharge of ammonium wastewater and pave the way for further study of the freezing process for wastewater treatment.
Application of 3-Dimensional Technology for Evaluating Muscular Type and Muscle-Fat Pad Mixed-Type Nasolabial Folds With Botulinum Toxin-A Treatment
Authors: Li Rou , Chen Xinyao , Sun Hai , Hao Lijun , Luo Sai 
Published: December 2022

Abstract

Background
Botulinum toxin-A (BTX-A) is used in the treatment of nasolabial folds (NLFs). However, lighting and clinician subjectivity play a major role in evaluating the efficacy of this treatment.

Objectives
By applying 3-dimensional (3D) technology, this study aimed to quantitatively evaluate the effects of BTX-A injection on muscular (M) and muscle–fat pad mixed-type (MF) NLFs.

Methods
BTX-A was injected into bilateral marked points on the NLFs, where the levator labii alaeque nasi, zygomaticus minor, and zygomaticus major pull the skin to form the NLF (2 U at each injection site). Pretreatment and posttreatment 3D facial images were captured with static and laughing expressions. The curvature, width, depth, and lateral fat volume of the NLFs were measured to compare the therapeutic efficacy for type M and MF NLFs.

Results
Thirty-nine patients with type M and 37 with type MF NLFs completed the follow-up data. In these patients, the curvature, width, and depth of the NLF showed a significant reduction at 1 month and gradually recovered at 3 and 6 months after treatment, with more significant improvement when laughing than when static. Variations compared to the pretreatment values of type MF were greater than those of type M at each time point. The lateral fat volume of the type MF NLF was significantly reduced (P &lt; .05).

Conclusions
3D technology can quantitatively evaluate the effects BTX-A injection for treating type M and type MF NLFs. BTX-A is more effective on type MF than on type M NLFs.

Level of Evidence: 4
syntenet: an R/Bioconductor package for the inference and analysis of synteny networks
Authors: Almeida-Silva Fabricio , Zhao Tao , Ullrich Kristian K , Schranz M Eric , Van de Peer Yves 
Published: December 2022

Abstract

Summary
Interpreting and visualizing synteny relationships across several genomes is a challenging task. We previously proposed a network-based approach for better visualization and interpretation of large-scale microsynteny analyses. Here, we present syntenet, an R package to infer and analyze synteny networks from whole-genome protein sequence data. The package offers a simple and complete framework, including data preprocessing, synteny detection and network inference, network clustering and phylogenomic profiling, and microsynteny-based phylogeny inference. Graphical functions are also available to create publication-ready plots. Synteny networks inferred with syntenet can highlight taxon-specific gene clusters that likely contributed to the evolution of important traits, and microsynteny-based phylogenies can help resolve phylogenetic relationships under debate.

Availability and implementation
syntenet is available on Bioconductor (https://bioconductor.org/packages/syntenet), and the source code is available on a GitHub repository (https://github.com/almeidasilvaf/syntenet).

Supplementary information
Supplementary data are available at Bioinformatics online.
konnect2prot: a web application to explore the protein properties in a functional protein–protein interaction network
Authors: Kumar Shivam , Sarmah Dipanka Tanu , Asthana Shailendra , Chatterjee Samrat 
Published: December 2022

Abstract

Motivation
The regulation of proteins governs the biological processes and functions and, therefore, the organisms’ phenotype. So there is an unmet need for a systematic tool for identifying the proteins that play a crucial role in information processing in a protein–protein interaction (PPI) network. However, the current protein databases and web servers still lag behind to provide an end-to-end pipeline that can leverage the topological understanding of a context-specific PPI network to identify the influential spreaders. Addressing this, we developed a web application, ‘konnect2prot’ (k2p), which can generate context-specific directional PPI network from the input proteins and detect their biological and topological importance in the network.

Results
We pooled together a large amount of ontological knowledge, parsed it down into a functional network, and gained insight into the molecular underpinnings of the disease development by creating a one-stop junction for PPI data. k2p contains both local and global information about a protein, such as protein class, disease mutations, ligands and PDB structure, enriched processes and pathways, multi-disease interactome and hubs and bottlenecks in the directional network. It also identifies spreaders in the network and maps them to disease hallmarks to determine whether they can affect the disease state or not.

Availability and implementation
konnect2prot is freely accessible using the link https://konnect2prot.thsti.in. The code repository is https://github.com/samrat-lab/k2p_bioinfo-2022.
Aortic stenosis and the haemostatic system
Authors: Trimaille Antonin , Hmadeh Sandy , Matsushita Kensuke , Marchandot Benjamin , Kauffenstein Gilles , Morel Olivier 
Published: December 2022

AbstractAortic stenosis (AS) affects more than 10% of the population over 80 years of age and constitutes a major risk factor for heart failure, thromboembolic stroke, and death. A better understanding of the disease, including its interaction with the haemostatic system, is a prerequisite to develop prophylactic treatments. AS pathogenesis is a dynamic process involving endothelial dysfunction, inflammation, fibrosis, and calcification. Several studies support the interplay between the components of the haemostatic system such as platelets, the coagulation system, von Willebrand factor, and extracellular micro-particles at each pathophysiological stage of AS. Previous reports have evidenced persistent biological activity of the native valve after transcatheter aortic valve replacement and the subsequent development of microthrombosis that may impact the function of the newly implanted valve. Here, we review the current evidence on the interplay between AS and prothrombotic activity, and we emphasize the clinical consequences of these interactions after aortic valve replacement.
Gender differences in Medicare payments to cardiothoracic surgeons in 2019
Authors: Kim SangMin , Kim Sun , Wang Sue X , Kanwar Ruhi , Bryan Darren S , Bueno Raphael , Marshall M Blair 
Published: December 2022

AbstractOBJECTIVESThe STS Thoracic Surgery Practice and Access Task Force - 2019 Workforce Report noted gender-based differences in the income of cardiothoracic surgeons in the United States. We analysed the 2019 Medicare payment data for thoracic and cardiac surgeons to investigate the gender-based payment gap among cardiothoracic surgeons.METHODSThe 2019 Medicare Physician and Other Practitioners by Provider and Services data set merged with the Doctors and Clinicians National Downloadable File was utilized to conduct a cross-sectional analysis of gender differences in Medicare payments, numbers of services, unique billing codes, years in practice, Medicare beneficiary age, regional population density (rural-urban commuting area code) and patient panel complexity (hierarchical condition category) for providers. The providers' self-reported gender (women or men) and provider type (thoracic surgery or cardiac surgery) were binarily set according to the Center for Medicare and Medicaid Services standards. Independent analyses were performed with thoracic and cardiac surgeons. We also used the 2013 and 2016 Medicare Physician and Other Practitioners by Provider and Services data sets to analyse the trends in adjusted gender-based payment differences across 2013, 2016 and 2019.RESULTSAfter controlling for the covariates, women thoracic surgeons received $25,183.50 [95% confidence interval (CI) $16,307.60, $34,059.40] less than the mean Medicare payment than men thoracic surgeons. Likewise, women cardiac surgeons received $20,960 [95% confidence interval (CI) $1,014.80, $40,902.80] less than the mean adjusted Medicare payment than their men counterparts.CONCLUSIONSIn 2019, women cardiothoracic surgeons received a significantly lower mean Medicare payment than men cardiothoracic surgeons after controlling for the number of services, unique billing codes, the complexity of the patient panel, years in practice and regional population density. The payment gap between women and men exhibited no statistically significant change over 2013, 2016 and 2019. Future studies are warranted to understand the association between gender representation and the pay gap.
The effect of living environmental factors on cardiovascular diseases in Chinese adults: results from a cross-sectional and longitudinal study
Authors: Yang Yao , Cao Limin , Xia Yang , Li Jian 
Published: December 2022

Abstract

Aims
This study aimed to investigate the association between multiple living environmental factors and cardiovascular diseases (CVDs).

Methods and results
This study was conducted on the China Health and Retirement Longitudinal Study (CHARLS), with 12 489 subjects in the cross-sectional study and 7932 subjects in the 7-year follow-up. Living environmental factors included ambient fine particulate matter (PM2.5), indoor fuel use, tap water use, and residence type. Logistic regression and Cox proportional hazard regression models were applied to explore the association between living environmental risk factors and CVD events in a cross-sectional and a cohort analysis, respectively. Compared with subjects in the low-risk groups, those in the middle-risk (odd ratio [OR], 95% confidence interval [CI]: 1.203, 0.943–1.534) and high-risk groups (OR, 95% CI: 1.616, 1.259–2.074) showed increased risks of CVD prevalence when considering the combined effects of their living environment. During the follow-up, similar associations were observed (hazard ratio [HR], 1.541, 95% CI [1.142–2.080] for the high-risk group; HR 1.296, 95% CI [0.968–1.736] for the middle-risk group); P for trend = 0.003).

Conclusion
An overall poor living environmental quality is a potential risk factor for CVD. Future studies should focus more on the effects of exposure to multiple factors.
Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation
Authors: Wang Bin , Stevenson Elizabeth-Lauren , Dunlap Jay C 
Published: December 2022

Abstract
In the negative feedback loop driving the Neurospora circadian oscillator, the negative element, FREQUENCY (FRQ), inhibits its own expression by promoting phosphorylation of its heterodimeric transcriptional activators, White Collar-1 (WC-1) and WC-2. FRQ itself also undergoes extensive time-of-day-specific phosphorylation with over 100 phosphosites previously documented. Although disrupting individual or certain clusters of phosphorylation sites has been shown to alter circadian period lengths to some extent, it is still elusive how all the phosphorylations on FRQ control its activity. In this study, we systematically investigated the role in period determination of all 110 reported FRQ phosphorylation sites, using mutagenesis and luciferase reporter assays. Surprisingly, robust FRQ phosphorylation is still detected even when 84 phosphosites were eliminated altogether; further mutating another 26 phosphoresidues completely abolished FRQ phosphorylation. To identify phosphoresidue(s) on FRQ impacting circadian period length, a series of clustered frq phosphomutants covering all the 110 phosphosites were generated and examined for period changes. When phosphosites in the N-terminal and middle regions of FRQ were eliminated, longer periods were typically seen while removal of phosphorylation in the C-terminal tail resulted in extremely short periods, among the shortest reported. Interestingly, abolishing the 11 phosphosites in the C-terminal tail of FRQ not only results in an extremely short period, but also impacts temperature compensation (TC), yielding an overcompensated circadian oscillator. In addition, the few phosphosites in the middle of FRQ are also found to be crucial for TC. When different groups of FRQ phosphomutations were combined intramolecularly, expected additive effects were generally observed except for one novel case of intramolecular epistasis, where arrhythmicity resulting from one cluster of phosphorylation site mutants was restored by eliminating phosphorylation at another group of sites.
AGE AS A DIVERSITY FACTOR IN HIGHER EDUCATION: INSIGHTS FROM DEI OFFICERS
Authors: Morrow-Howell Nancy , Galucia Natalie , Dinman Michele 
Published: December 2022

Abstract
This study described how DEI officers across universities/colleges currently think about AGE as a diversity factor; and identified strategies used to increase age-inclusivity. Data were generated through review of university websites, focus groups and one-to-one interviews with DEI staff. Findings suggest that age is acknowledged as a diversity factor but there is less action toward strategies to increase age-inclusion. Examples of initiatives include: training human resource staff to be age-neutral in hiring; eliminating birthdates and other years from applications; workshops on multigenerational workplaces and classrooms; presentations on ageism; and specific programs to support non-traditionally aged students. Some of the motivation to address ageism stems from legal mandates rather than being mission-driven. There is the concern that focusing more on age may require moving attention and resources away from other diversity factors. It appears that there is interest in elevating age as an important factor in DEI efforts.