bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report on Acute Cerebrovascular Episode With Pseudobulbar Palsy.
Authors: Warghane Utkarsh manoj , Sharma Ranjana , Pohekar Savita , Warghane Ashish Janraoji 
Published: June 2023

Abstract
nervous system (PNS), or both are referred to as cerebrovascular disorders. In India, there are 145 cases of cerebrovascular disorders for every 100,000 individuals. There are two different forms of stroke. There are two types of strokes: ischemic and haemorrhagic. There are some parallels between the two different forms of stroke. Etiology, pathophysiology, and medical management differ from nursing management in these areas. A clinical condition known as an ischemic stroke, often referred to as a cerebrovascular accident (CVA) or a cerebrovascular event, occurs when there is a sudden loss of function caused by an interruption in the blood flow to any area of the brain. Additionally, a cerebrovascular accident damages the central nervous system and results in bulbar palsy, which is characterized by the inversion of muscular motion caused by cranial nerves in the lower part of the brain stem
Case presentation: A 64-year-old man who was receiving ayurvedic treatment complained of facial dropping, left-side weakness, speech difficulty, and breathing difficulties. According to his medical history, the patient appeared healthy before the incident occurred and had a history of sane events one month prior. There is no prior history of loss of consciousness or seizure episodes at home. An early investigation was done, including a CT scan of the brain, which revealed acute infract on the left and right corona radiata as well as age-related atrophic changes and small vessel disease. Sepsis with a cerebrovascular episode and pseudobulbar palsy was the final diagnoses.
Conclusion: A type of ischemic stroke that affects the central nervous system is a cerebral vascular accident. Having an incidence rate of 145 patients in 100,000 patients. And men are more likely to get pregnant than women (2.39% vs. 1.22%) Urban communities reported slightly more strokes than rural areas did. (2.01% vs. 1.57%). (6) However, early detection and treatment are lowering the death rate and lowering the chance of developing diseases.
Impact of on-site pharmacists in residential aged care facilities on the quality of medicines use: a cluster randomised controlled trial (PiRACF study)
Authors: Haider Ibrahim , Kosari Sam , Naunton Mark , Niynosenga Theo , Koerner Jane , Peterson Gregory , Davey Rachel 
Published: June 2023

Abstract
Residents of residential aged care facilities (RACFs) have a high prevalence of use of potentially inappropriate medications (PIMs) and resultant medicines-related harm. This study investigated the effect of an on-site pharmacist model on PIMs use and other medication outcomes for residents in RACFs. A multi-facility, non-blind, cluster randomised controlled trial, with randomisation at the facility level, was conducted. Fifteen facilities enrolled and participated in the study, 7 facilities (560 residents) were allocated to the intervention arm and 8 facilities (737 residents) were allocated to the control arm. Each facility in the intervention arm employed an on-site pharmacist for 12 months to perform medication management activities as part of an interdisciplinary care team. The primary outcome was the proportion of residents taking at least one PIM according to the 2019 Beers® Criteria. Using generalised linear mixed-effects models, accounting for confounders and clustering, there was a significant reduction in the proportion of residents prescribed at least one PIM (odds ratio 0.50, 95% confidence interval, 0.335–0.750; p = 0.001) in the intervention arm. There were also significant decreases in the Anticholinergic Cognitive Burden scale and chlorpromazine equivalent daily dose of antipsychotics. The on-site pharmacist intervention significantly improved the appropriateness of medicines use in RACFs.
A proposed new Precambrian skarn deposits in the Arabian shield
Authors: Aboezz Eid , Selim El Sayed , Aboelkhair Hatem , Sehsah Haytham 
Published: June 2023

Abstract
The volcanosedimentary arc-related skarn deposits are the predominant types in the Arabian Shield (AS). However, the post-amalgamation extraordinary marine basins with carbonate successions exist in the AS, intruded by different types of granite plutons, and dissected by major shear zones. Therefore, all the recipes for skarn deposits are mature at the contact between the carbonate succession in the marine molasse basins and granite plutons. Magnetic data and ASTER data were integrated with the geochemical database to locate the preliminary areas for further exploration in the Murdama basin. The Murdama basin (72,000 km2), which is the locality for the Murdama limestone, has a higher magnetic anomaly at the contact with post-Murdama granite batholiths, but the magnetic anomaly becomes significant at the contact with the Idah granitic suite. The shallow-seated structural magnetic lineaments within the Murdama basin and at the eastern boundary of the basin are controlled by the Najd fault system (NFS). The calc-silicate mineral alteration zones were evolved at the contact between the Murdama group and the Idah suite, with no extent for the alteration zones along the fracture network or at the contact with the Abanat suite. Meanwhile, the Idah suites are the causative plutons for the Qitan and An Nimriyah South reduced skarns that were recorded from the Murdama basin. The preliminary results from this study based on the integration of different datasets suggest the existence of reduced skarn deposits at the contact between the Murdama basin and Idah causative plutons
Pro-Social Preferences Improve Climate Risk Management in Subsistence Farming Communities
Authors: Choquette-Levy Nicolas , Wildemeersch Matthias , Santos Fernando , Levin Simon , Oppenheimer Michael , Weber Elke 
Published: June 2023

Abstract
Several governments have tested formal index-based insurance to build climate resilience among smallholder farmers. Yet, adoption of such programs has generated concerns that insurance may crowd out long-established informal risk transfer arrangements. Understanding this phenomenon requires new analytic approaches that capture dynamics of human social behaviour when facing risky events. Here, we develop a modelling framework, based on evolutionary game theory and empirical data from Nepal and Ethiopia, to demonstrate that insurance may introduce a new social dilemma in farmer risk management strategies. We find that while socially optimal risk management is achieved when all farmers pursue a combination of formal and informal risk transfer, a community of self-interested agents is unable to maintain this coexistence at moderate to high covariate risks. We find that a combination of pro-social preferences - namely, moderate altruism and solidarity - helps farmers overcome these concerns and achieve the social optimum. Behavioural interventions that cue such preferences can render financial incentives more efficient in promoting optimal climate risk management, with potential savings worth approximately 5-15 percent of community agricultural income under a range of risk levels.
Parameter Sensitivity Analysis of SWMM model in an Airport Airfield Area
Authors: Peng Jing , Zhao Hucheng , Jie Ouyang , Yu Lei , Zhong Xiang 
Published: June 2023

Abstract
Storm Water Management Model (SWMM) and Geographic Information System (GIS) can provide prediction and management for airport flood problems. Efficient and accurate acquisition of sensitive parameters is the key to real-time model calibration. Due to the influence of special land types, functional zoning and use requirements of airports, there are many problems in parameter sensitivity analysis, such as large sampling parameters, large amount of calculation, and nonlinear correlation between input and output variables. In this paper, the SWMM model of airport airfield area is built, combining GIS and Python programming technology and using Latin Hypercube sampling, a correlation analysis method is proposed to study whether the input parameters have nonlinear correlation with the output results and its strength, and compared with the improved Morris screening method. The results show that, the sensitivity of parameters is more balanced for the total inflow, there is no very sensitive parameter, and the nonlinear correlation between the parameters and the total inflow is weak. Manning-N is sensitive to average depth, hour of maximum flooding, and time to peak, which indicates that there is a strong nonlinear correlation between them and Manning-N. From the improved Morris screening analysis, it can be seen that there are no highly sensitive parameters for peak flow, and the sensitive parameters are Zero-Imperv and Manning-N. Highly sensitive parameters for time to peak are Manning-N, N-perv, S-Imperv, and N-Imperv. This paper quantitatively analyzes the influence of input parameters of the storm water management model on the output results, effectively identify the important parameters that affecting the output results, and analyze the nonlinear correlation between the input parameters and the output results. The results can greatly improve the accuracy of airport flood model, and provide theoretical guidance for the application and parameter calibration of SWMM in airport.
Expression and gene regulatory network of S100A16 protein in cervical cancer cells based on data mining
Authors: Zhang Haibin , Xing Wenhu , Zhang Shan , Yang Yongxiu , Li Yufeng 
Published: June 2023

Abstract
S100A16 protein belongs to the S100 family of calcium-binding proteins, which is widely distributed in human tissues and highly conserved. S100 calcium-binding proteins possess broad biological functions, such as cancer cell proliferation, apoptosis, tumor metastasis, and inflammation (1). Studies have shown an integral role of S100 calcium-binding proteins in the diagnosis, treatment, and prognosis of certain diseases (2). Abnormal expression of S100A16 protein is implicated in the progression of breast and prostate cancer, but an inhibitor of oral cancer and acute lymphoblastic leukemia tumor cell proliferation (3). Referencing the mRNA expression and SNP data of cervical cancer available through The Cancer Genome Atlas (TCGA) database, we analyzed S100A16 and its associated regulatory gene expression network in cervical cancer. We further screened genes co-expressed with S100A16 to hypothesize their function and relationship to the S100A16 cervical cancer phenotype. Our results showed that data mining can effectively elucidate the expression and gene regulatory network of S100A16 in cervical cancer, laying the foundation for further investigations into S100A16 cervical tumorigenesis.
A case of Medullary Thyroid Carcinoma diagnosed with sustained high level of procalcitonin in a critically ill patient. The importance of clinical suspicion
Authors: Cengiz Burak Can , Musa Civak , Ates İhsan 
Published: June 2023

Abstract
Medullary thyroid carcinoma (MTC) is a thyroid cancer that originates from the parafollicular C cells and accounts less than five percent of all thyroid cancer cases (1). It can be sporadic or part of a familial syndrome (2). Diagnosis in the routine clinical practice is difficult since the detection rate is low with fine needle aspiration and the ultrasonographic features are not reliable (3). Although serum calcitonin is the most accurate marker for the diagnosis there is no specific cut off for excluding MTC with certainty and different potential cutoff values have been reported in literature (4). There are also few cases of MTC without calcitonin elevation in the literature (5). Serum calcitonin levels can vary during the day because of its pulsatile secretion (6). Calcitonin also can be in different immunoreactive isoforms leading different results with different assays. Moreover, calcitonin is an unstable peptide and is rapidly degraded by protease enzymes in the room temperature. Even it is refrigerated 23% decays in the first twelve hours that can lead a false test result (7).
Syk-dependent alternative homologous recombination activation promotes cancer resistance to DNA targeted therapy
Authors: Zhou Qin , Tu Xinyi , Hou Xiaonan , Yu Jia , Zhao Fei , Huang Jinzhou , Kloeber Jake , Olson Anna , Gao Ming , Luo Kuntian , Zhu Shouhai , Wu Zheming , Zhang Yong , Sun Chenyu , Zeng Xiangyu , Schoolmeester Kenneth , Weroha John , Wang Liewei , Mutter Robert , Lou Zhenkun 
Published: June 2023

Abstract
Enhanced DNA repair is an important mechanism of inherent and acquired resistance to DNA targeted therapies, including poly ADP ribose polymerase inhibition. Spleen associated tyrosine kinase (Syk) is a non-receptor tyrosine kinase known to regulate immune cell function, cell adhesion, and vascular development. Here, we report that Syk can be expressed in high grade serous ovarian cancer and triple negative breast cancers and promotes DNA double strand break resection, homologous recombination (HR) and therapeutic resistance. We found that Syk is activated by ATM following DNA damage and is recruited to DNA double strand breaks by NBS1. Once at the break site, Syk phosphorylates CtIP, a key mediator of resection and HR, at Thr-847 to promote repair activity, specifically in Syk expressing cancer cells. Syk inhibition or genetic deletion abolished CtIP Thr-847 phosphorylation and overcame the resistant phenotype. Collectively, our findings suggest that Syk drives therapeutic resistance by promoting DNA resection and HR through a novel ATM-Syk-CtIP pathway, and that Syk is a new tumor-specific target to sensitize Syk-expressing tumors to PARPi and other DNA targeted therapy.
Olive oil consumption is associated with lower cancer mortality among Italian adults: prospective results from the Moli-sani Study and analysis of potential biological mechanisms
Authors: Ruggiero Emilia , Castelnuovo Augusto Di , Costanzo Simona , Esposito Simona , de Curtis Amalia , Persichillo Mariarosaria , Cerletti Chiara , Donati Maria Benedetta , de Gaetano Giovanni , Bonaccio Marialaura , Iacoviello Licia 
Published: June 2023

Abstract

Background: Olive oil is a key component of a traditional Mediterranean Diet and its with cancer mortality is less robust, and it remains unclear whether the health advantages of olive oil may be accounted for by specific biological mechanisms.
We therefore sought to investigate the relationship between olive oil consumption with cancer mortality in an Italian general population, and to examine specific biological pathways common to major chronic diseases as possibly underlying these associations.
Methods: Longitudinal analysis on 22,895 men and women (mean age 55.4±11.7y) from the Moli-sani Study (enrolment, 2005-2010) followed up for 12.2 years. Olive oil consumption was standardized to a 10 g tablespoon (tbsp) size.
Results: Compared with individuals who rarely consumed olive oil (≤1.5 tbsp/d), participants who had the highest consumption (>3 tbsp/d) reported 28% lower rate in cancer death (HR= 0.72; 95% CI: 0.54-0.94), and a linear dose-response relationship was also observed (p value for association=0.030; p for non-linearity =0.47). Among known risk factors analysed, lower levels of blood pressure and resting heart rate associated with consumption of olive oil accounted for 14.5% and 8.1% of its inverse relationship with all-cause and cancer mortality, respectively; all biomarkers here analysed explained 28.0% and 12.3% of such relationships.
Conclusions: Higher olive oil consumption was associated with higher survival that was largely driven by a reduction in cancer mortality, independent of overall diet quality. Known risk factors for major chronic diseases mediate only in part such associations suggesting that other biological pathways are potentially involved in this relationship.
Extracellular matrix flow guides emergent in-vitro morphogenesis
Authors: Fattah Abdel Rahman Abdel , Sgualidino Francesca , Poovathingal Suresh , Davie Kristofer , Baatsen Pieter , Vints Katlijn , Gounko Natalia , Superti-Furga Giulio , Mattolini Lorenzo , Roussigne Myriam , Benazeraf Bertrand , Ranga Adrian 
Published: June 2023

Abstract

Morphogenesis of vertebrate embryos requires extracellular matrix (ECM) in multiple developmental contexts1. Symmetry-breaking events in initially homogenous tissues trigger collective cellular dynamics which follow fluid-like behaviors, and the ECM, which is in constant engagement with morphing tissues, also undergoes fluid-like motion2–4. Cell and ECM deformations require coordination, however the interplay between them at cellular and tissue-scale remains largely unexplored. Here, we reveal a novel mechanism coupling morphogenetic events and epithelia-driven ECM flow. We show that exposure to ECM components triggers periodic morphogenesis of dome-shaped structures in human pluripotent stem cell monolayers, driven by directional ECM flow towards the sites of morphogenesis. We show that this flow is initiated by local symmetry-breaking events, is driven by microvilli and requires unperturbed flow conditions and cytoskeletal contractility. A theoretical model shows that a reaction-diffusion-like mechanism is responsible for organizing local morphogenesis into global tissue-wide events. The cell patterning landscape predicted by the model is experimentally recapitulated during mesoderm differentiation. These results uncover a new role for the ECM: in addition to being a site of cell adhesion, structural support and mechanical force generation5, as is currently established, we show that directional transport of ECM, termed ECM flow, is a major contributor in sustaining epithelial morphogenesis and differentiation.
Salt tolerance of two different varieties of tobacco under NaCl stress
Authors: Wang yuelin , Zhou Hanjun , Xu Liang , Ye Xiefeng 
Published: June 2023

Abstract

Background
In the context of increasing global soil salinization, reducing the damage caused by soil salinity and improving the salt tolerance of crops has become an urgent issue in modern agriculture. However, few studies have reported on the different salt tolerance performances of different varieties of tobacco crops under salinity stress due to the gradual evolution of geographical separation.
Results
The aim of this study was to investigate the different performances of Basma (Spice tobacco) and K326(Flue-cured tobacco) under NaCl stress in order to find a more effective method to improve salt tolerance in tobacco. In this study, Basma and K326 were treated with a 150 mM NaCl solution, and a blank control treatment was included. Physiological indicators such as root length growth, antioxidant enzyme activity, ion concentration, hormone content, and related gene expression were measured. In the plate medium, the root length growth of K326 under NaCl stress treatment was only 60% of that of Basma, which had higher salt tolerance. The reasons for this difference mainly concentrated on three aspects. Firstly, in Basma, the accumulation of reactive oxygen species caused by salt stress is scavenged by increasing the activity of antioxidant enzymes, and the damage to the plasma membrane is decreased. Secondly, the ion toxicity caused by salt stress is relieved by increasing the expression of the SOS1 gene in the roots, which can balance the intracellular osmotic pressure and maintain ion balance. Lastly, the expression of PIN4, a key gene in growth hormone transport, is upregulated to obtain antigravity transport of growth hormone and increase IAA content in roots, promoting root growth.
Conclusion
In this study, it was found that oriental tobacco Basma demonstrated greater resistance to salt stress compared to flue-cured tobacco K326. This was primarily observed in the root growth and activity, as well as in significant differences in physiological indexes such as active oxygen accumulation, ion distribution regionalization, and hormone content distribution. The experimental results suggest that Basma achieves strong salt tolerance through three main mechanisms: increasing the activity of antioxidant enzymes to eliminate ROS accumulation, expressing SOS1 to adapt to ion regionalization under salt stress, regulating sodium-potassium ratio, and increasing the expression of IAA polar transporter gene PIN4 to maintain a balance of IAA content.
Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis
Authors: Zhang Bin , Li Jie , Wang Yijun , Liu Xixi , Yang Xiao , Liao Zhiyun , Deng Suke , Deng Yue , Zhou Zhiyuan , Tian Yu , Wei Wenwen , Meng Jingshu , Hu Yan , Wan Chao , Zhang Zhanjie , Huang Fang , Wen Lu , Wu Bian , Li Yan , Yang Kunyu , Sun Yajie 
Published: June 2023

Abstract
Cisplatin-based chemotherapy improves the control of distant metastases in patients with nasopharyngeal carcinoma (NPC); however, around 30% of patients fail treatment due to acquired drug resistance. Epigenetic regulation is known to contribute to cisplatin resistance; nevertheless, the underlying mechanisms remain poorly understood. Here, we showed that lysine-specific demethylase 5B (KDM5B) is overexpressed and correlates with tumor progression and cisplatin resistance in patients with NPC. We also showed that specific inhibition of KDM5B impairs the progression of NPC and reverses cisplatin resistance, both in vitro and in vivo. Moreover, we found that KDM5B inhibits the expression of ZBTB16 by directly reducing H3K4me3 at the ZBTB16 promoter, which subsequently increases the expression of Topoisomerase II- α (TOP2A) to confer cisplatin resistance in NPC. In addition, we showed that the deubiquitinase USP7 is critical for deubiquitinating and stabilizing KDM5B. More importantly, the deletion of USP7 increases sensitivity to cisplatin by disrupting the stability of KDM5B in NPC cells. Therefore, our findings demonstrate that USP7 stabilizes KDM5B and promotes cisplatin resistance through the ZBTB16/TOP2A axis, suggesting that targeting KDM5B may be a promising cisplatin-sensitization strategy in the treatment of NPC.
Using Tree-Based Models to Identify Factors Contributing to Trait Negative Affect in Adults With and Without Major Depression
Authors: Canizares Catalina , Gomez Yvonne , Ferro Eugenio , Torres Carlos Arturo , Agudelo Diana Maria , Odom Gabriel 
Published: June 2023

Abstract

Background
Individuals with high levels of negative affect (NA) are at an increased risk of experiencing distress and negative self-views. Theoretical models suggest that NA plays a critical role in psychopathology, particularly in Major Depressive Disorder (MDD), and is linked to cognitive-perceptual and affective regulation issues.
Objective
Determine whether maladaptive cognitive schemas, attributional style, childhood adversity, and lifestyle factors (including alcohol and drug use and physical activity) could effectively predict negative affect (NA) in adults.
Methods
A secondary data analysis was performed on a sample of 342 depressed and non-depressed adults. Beta regression and regression tree analyses were conducted to identify the principal risk factors and their interactions. The regression tree model was trained with 5-fold cross-validation on 75% of the sample, with 25% of observations held for testing.
Results
The findings revealed that the cognitive schemas of disconnection and rejection and impaired autonomy had a significant impact on the likelihood of higher scores on the State Depression Inventory (IDER) test (p < 0.001), as indicated by both beta regression and regression tree analyses. Additionally, childhood adversity emerged as a crucial factor in determining high levels of NA. The regression tree model achieved strong performance metrics, including an R-squared value of 0.77.
Conclusions
This study represents a significant step forward in the understanding of NA, as it considers a broad range of individual factors, such as cognitive schemas, lifestyle, and demographics, to predict its impact on NA, with potential implications for prevention programs aimed at reducing NA.