bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and severity of cytomegalovirus infection in seropositive heart transplant recipients
Authors: Gardiner Bradley J. , Bailey Jessica P. , Percival Mia A. , Morgan Beth A. , Warner Victoria M. , Lee Sue J. , Morrissey C. Orla , Kaye David M. , Peleg Anton Y. , Taylor Andrew J. 
Published: March 2023

AbstractBackgroundThe frequency and significance of cytomegalovirus (CMV) infection in seropositive (R+) heart transplant recipients (HTR) is unclear, with preventative recommendations mostly extrapolated from other groups. We evaluated the incidence and severity of CMV infection in R+ HTR, to identify risk factors and describe outcomes.MethodsR+ HTR from 2010 to 2019 were included. Antiviral prophylaxis was not routinely used, with clinically guided monitoring the local standard of care. The primary outcome was CMV infection within one‐year post‐transplant; secondary outcomes included other herpesvirus infections and mortality.ResultsCMV infection occurred in 27/155 (17%) R+ HTR. Patients with CMV had a longer hospitalization (27 vs. 20 days, unadjusted HR 1.02, 95% CI 1.00–1.02, p = .01), higher rate of intensive care readmission (26% vs. 9%, unadjusted HR 3.46, 1.46–8.20, p = .005), and increased mortality (33% vs. 8%, unadjusted HR 10.60, 4.52–24.88, p < .001). The association between CMV and death persisted after adjusting for multiple confounders (HR 24.19, 95% CI 7.47–78.30, p < .001). Valganciclovir prophylaxis was used in 35/155 (23%) and was protective against CMV (infection rate 4% vs. 27%, adjusted HR .07, .01–.72, p = .025), even though those receiving it were more likely to have received thymoglobulin (adjusted OR 10.5, 95% CI 2.01–55.0, p = .005).ConclusionsCMV infection is common in R+ HTR and is associated with a high burden of disease and increased mortality. Patients who received valganciclovir prophylaxis were less likely to develop CMV infection, despite being at higher risk. These findings support the routine use of antiviral prophylaxis following heart transplantation in all CMV R+ patients.
Confirmation of the presence of the pistachio psyllid Agonoscena pistaciae Burckhardt & Lauterer, 1989 in Spain
Authors: Rodrigo‐Gómez Sara , Burckhardt Daniel 
Published: March 2023

AbstractAgonoscena pistaciae is a serious pest of pistachio in the Middle East and the Eastern Mediterranean. In this paper the presence of the species in Spain and Western Europe is confirmed. It is widespread in the regions of Castilla–La Mancha and Extremadura in Central Spain, where it develops mostly on Pistacia terebinthus, in contrast to the Middle East, where its preferred host is Pistacia vera. In the literature and internet sources, A. pistaciae is often confused with other, morphologically similar species, namely A. succincta and A. targionii. Morphological characters are listed and illustrated for the identification of the species found in the West Mediterranean.
Detecting impersonation episode using teaching learning‐based optimization and support vector machine techniques
Authors: Shukla Alok Kumar 
Published: March 2023

AbstractOver the last few decades, computer and internet security has become a vital area because of eye‐opening numbers of data breaches, intruders on perilous infrastructure and malware attacks that are increasing day by day. In order to monitor abnormal activities and identify unusual attacks, several security solutions have been proposed in the recent past years. To protect computer system, intrusion detection system (IDS) opens up great opportunities to determine vulnerabilities and detect anomalies in security system. For detecting new attacks or building security solutions, in this study we present a new wrapper technique for security specialists that can help to detect more complicated attacks by combining teaching learning‐based optimization with opposition learning scheme and simulated annealing method. In order to address advance attack, firstly opposition learning strategy is used to update population generation of teaching learning‐based optimization that affect the robustness of the model after that simulated annealing is integrated into the teaching learning‐based optimization. In proposed method to choose the relevant features, we have used support vector machine as a fitness function that can be helped to recognize attacks precisely. The proposed algorithm is evaluated on three popular datasets namely NSL‐KDD, ISCX 2012 and UNSW‐NB15. Experimental results show that the proposed method is superior to other existing wrapper algorithms in terms of detection rate, accuracy and false alarm rates.
Doing “gendered exit”: Work, care and the moral practices of disabled persons
Authors: Fang Zhilan , Liu Gabriel , Zhu Liling , Dong Dong 
Published: March 2023

AbstractPrevious research into the exclusion of disabled persons from paid work tends to compartmentalize them into a stable and undifferentiated category of “cared‐for” subjects. This fixation implicitly approves the ethics of work as the exclusive source of their dignity and citizenship. Drawing on in‐depth interviews with Myasthenia Gravis patients and their families, this paper argues that a subscription to the logic of interdependence that organizes the ethics of care enables our participants to transcend the conventional carer/cared‐for dichotomy. However, the patriarchal structures in which the agency of our participants finds expression create a gendered distribution of care. By delimiting the possibilities of social membership for disabled persons, this paper embraces the care ethics as an alternative to that of work. It nevertheless circumscribes care by bringing into relief its differential and contingent qualities.
The effects of free radicals and metal ion on milk protein β‐lactoglobulin (BLG) glyco‐oxidation
Authors: Shen Yixiao , Dong Qi , Yu Ziyin , Kong Youmeng , Kong Yiru , Yan Haixia , Chen Xu , Liu Ling 
Published: March 2023

SummaryIn this study, the effects of H2O2, 2,2′‐Azobis(2‐amidinopropane) dihydrochloride (AAPH) and metal ion Fe3+ on β‐lactoglobulin (BLG) glyco‐oxidation were investigated. The results demonstrated all the three inducers caused BLG morphology change and higher molecular weight BLG‐glucose (BLG‐Glu) adducts formation. H2O2 and AAPH significantly accelerated BLG oxidation by increasing carbonyl content and decreasing freesulphydryls (P < 0.05). However, Fe3+ showed little influence on carbonyl and free sulphydryls contents. All the three inducers promoted fluorescent‐advanced glycation end products (fl‐AGEs) and carboxymethyl‐lysine (CML) formation. Fe3+ and H2O2 (0.5% and 1%) could increase methylglyoxal (MGO) level and caused less time to reach its peak concentration than control group. Compared with the control group, new glycation sites were determined in H2O2, AAPH and Fe3+ treatments, indicating the inductive effect of those free radicals or metal ion on BLG glycation. The results will provide important information for the control of protein‐based products glyco‐oxidation during food processing and storage.
Transitions in smoking status in nursing students: A prospective longitudinal study
Authors: Laroussy Kenza , Castellano Yolanda , Fu Marcela , Baena Antoni , Feliu Ariadna , Peruga Armando , Margalef Mercè , Aldazabal Jon , Tigova Olena , Galimany Jordi , Puig Montserrat , Moreno Carmen , Bueno Albert , López Antonio , Roca Judith , Saura Judith , Fernández Esteve , Martínez Cristina 
Published: March 2023

AbstractAimTo describe transitions in smoking status and their determining factors among nursing students between baseline (2015–2016) and follow‐up (2018–2019).DesignObservational prospective longitudinal study of 4381 nursing students in Catalonia (Spain).MethodsWe examined transitions in smoking status from: (i) current smokers to recent quitters, (ii) never smokers to new smokers and (iii) former smokers to quitters who relapsed. We fitted logistic regression models to assess the predictors of quitting smoking.ResultsThe proportion of current smokers decreased from 29.7% at baseline to 23.6% at follow‐up, with a cumulative incidence rate of quitting of 28.3% during follow‐up. Nondaily smokers were more likely to quit than daily smokers. Of those who were never smokers at baseline, 4.6% were smokers at follow‐up, and 23.2% of former smokers at baseline had relapsed at follow‐up.ConclusionsNondaily smokers were more likely to have quit smoking at follow‐up among this cohort of nursing students. The early implementation of a comprehensive tobacco control program that includes tobacco‐free campus policies, tobacco prevention interventions and cessation support during college years may decrease tobacco use among nursing students.ImpactNursing students' tobacco use is concerning, as they are the future workforce of nurses who have a key role in tobacco product use prevention and cessation. During college years, nursing students have a greater likelihood of experimenting with several smoking status changes as well as to consolidate smoking behaviors. This is the first longitudinal study to highlight the factors associated with quitting smoking among a cohort of Spanish nursing students. Being a nondaily smoker at baseline predicted quitting at follow‐up. Our findings support the early implementation of a comprehensive tobacco control program that includes tobacco‐free campus policies, tobacco prevention interventions and tobacco cessation support during college years to decrease tobacco product use prevalence among nursing students.Reporting MethodWe have adhered to STROBE guidelines. No Patient or Public Contribution. This observational study has not been registered.
The Balanced View of the Value of Conscience
Authors: McConnell Doug , Savulescu Julian 
Published: March 2023

ABSTRACTOn the mainstream view, consciences are valuable because they promote moral unity. However, conscience, so defined, will systematically prevent moral growth that threatens unity, even when unity has formed around oppressive moral values. This motivates Carolyn McLeod's alternative ‘Dynamic View’ whereby consciences are valuable to the extent that they are dynamic. Consciences are dynamic when they interact with our best moral judgements to shape or ‘retool’ the moral values underpinning conscience, sometimes at an initial cost to unity. We modify and extend McLeod's account in two ways: (1) We object to her claim that conscience encourages its own retooling. We argue that the opposite is true – conscience creates a motivational barrier to change that moral judgement must overcome to successfully retool conscience. The task of ensuring dynamism, therefore, falls to moral judgement. (2) However, this motivational barrier enables conscience to play a valuable role that McLeod overlooks – compensating for the limitations of moral judgement. On our Balanced View, the value of conscience depends on it being sufficiently open to being shaped by our best moral judgements but inert enough to compensate for distorted moral judgements and to guide action when under cognitive load.
Effects of mode of heat transfer on puffing quality of rice grain: A modeling and simulation analysis
Authors: Lata Sneh , Swarnakar Ajay Kumar , Kumar Ashok , Das Susanta Kumar 
Published: March 2023

AbstractCereal grains can be puffed by heating in hot sand bed or domestic microwave oven. The purpose of this study was to explore and compare the reasons of transformational changes in preconditioned rice during its sand bed heating and microwave heating in domestic microwave oven. Mathematical modeling and simulation techniques were used to estimate the changes in microwave power absorption density and temperature of rice with the heating methods. Sand puffing, initiated from the tips of rice, progressed toward the central region of the rice following the change in temperature profile of rice and outcomes were completely puffed rice. The rice grains, placed in the different radial zones on the turntable of oven cavity, experienced nonuniform and inconsistent rate of microwave power absorption within the rice due to its placement and rotation, the oven factors, grain's shape, size, and dielectric properties. Microwave puffing, initiated from the central region of rice, progressed toward the tips of the rice. The slow rate of heating resulted in evaporative cooling of rice and most of the rice were unable to puff completely. However, the rate of microwave heating of rice was comparable with that of sand heating and about 92.0 ± 2.3% puffed was observed when rice was place in radial zone of 5.0 cm. Hence, the exact placement of rice in the oven cavity was required for achieving good puffing quality of rice.Practical applicationsThe present study helps to understand the reasons for uneven puffing of rice in domestic microwave oven. This understanding of puffing process in domestic microwave oven provides an opportunity to develop strategy for microwave puffing of rice or design a specific microwave puffing equipment suitable for achieving quantitative and qualitative puffing of rice.
Catching the aging curve early
Authors: Voropai Daria , Kroeskop Annebeth 
Published: March 2023

AbstractIn the field of Cosmetic Medicine, more and more younger individuals seek treatments and are looking further than only beautification and catching the aging curve early by improving the internal metabolism and strengthening the tissues. There is a promising niche evolving to meet these goals. The current article discussed one of the possibilities and techniques to catch this curve.
Typing Performance and Technique of Higher Education Students with Specific Learning Disorders
Authors: Abecassis Sharon , Magen Hagit , Weintraub Naomi 
Published: March 2023

AbstractHigher education students with specific learning disorders (SLD) often experience difficulties in basic learning skills, including typing on computers, which has become the most common writing mode for academic purposes. This may affect their academic performance. We compared the typing performance, product, and technique (screen gaze, finger use) of 35 SLD and 30 typically developing (TD) students using keylogging software. Compared to TD peers, students with SLD typed more slowly and less accurately, and gazed less at the screen, suggesting a less effective typing technique. They typed slower even after controlling for screen gaze, implying that additional factors may account for their lower typing speed such as language processing. Hence, students with SLD may benefit from typing instruction alongside test accommodations during computer‐based exams.
Challenges facing standardised patients representing equity‐deserving groups: Insights from health care educators
Authors: Sibbald Matt , Last Nicole , Keuhl Amy , Azim Arden , Sheth Urmi , Khalid Faran , Banji Farhan , Geekie‐Sousa Aaron , Yilmaz Derya Uzelli , Monteiro Sandra 
Published: March 2023

AbstractIntroductionHealth professions training programmes increasingly rely on standardised patient (SP) programmes to integrate equity‐deserving groups into learning and assessment opportunities. However, little is known about the optimal approach, and many SP programmes struggle to meet these growing needs. This study explored insights from health care educators working with SP programmes to deliver curricular content around equity‐deserving groups.MethodsWe interviewed 14 key informants in 2021 who were involved in creating or managing SP‐based education. Verbatim transcripts were analysed in an iterative coding process, anchored by qualitative content analysis methodology and informed by two theoretical frameworks: sociologic translation and simulation design. Repeated cycles of data collection and analyses continued until themes could be constructed, aligned with existing theories and grounded in empirical data, with sufficient relevance and robustness to inform educators and curricular leads.ResultsThree themes were constructed: (i) creating safety for SPs paid to be vulnerable, (ii) fidelity as an issue broader than who plays the role and (iii) engaging equity‐deserving groups. SP work involving traditionally marginalised groups risk re‐traumatization, highlighting the importance of (i) informed consent in recruiting SPs, (ii) separating role portrayal from lived experiences, (iii) adequately preparing learners and facilitators, (iv) creating time‐outs and escapes for SPs and (v) building opportunity for de‐roling with community support.ConclusionsSP programmes are well positioned to be allies and advocates to equity‐deserving groups and to collaborate and share governance of the educational development process from its outset. SP programmes can support the delivery of curricular content around equity‐deserving groups by advocating with curricular leadership, building relationships with community partners, facilitating co‐creation and co‐delivery of educational content and building safety into simulation.
The Rome Foundation Global Epidemiology study: Conception, implementation, results, and future potential
Authors: Sperber Ami D. 
Published: March 2023

BackgroundMethodological problems have impeded successful epidemiological research into disorders of gut‐brain interactions (DGBI), as previous studies were limited in terms of study population, diagnostic criteria, number of disorders assessed, data collection methods, and geographic area. Most prevalence estimates were based on pooling data from heterogeneous studies using inappropriate pooling methods, seriously limiting the relevance of the results. The Rome Foundatiion Global Epidemiology Study (RFGES) aimed to rectify these limitations using rigorous methodology to survey the prevalence of 22 DGBI in large population samples in 33 countries. Its aims were to conduct a comprehensive, multinational epidemiological study using rigorous research methodology, gain a better understanding of the burden of the DGBI, gain reliable regional estimates of DGBI prevalence, and advance our understanding of the pathophysiology of IBS. The study questionnaire consisted of the 89‐item Rome IV Adult Diagnostic Questionnaire enabling the diagnosis of 22 DGBI, and an 80‐item supplemental questionnaire that enabled analyses of the association of multiple factors with DGBI diagnoses.Purpose for review articleThis review paper introduces a special issue on the Rome Foundation Global Epidemiology study (RFGES) with a narrative description of its conception, development, and implementation, its outcomes to date, and its potential contribution to neurogastroenterology. It includes 15 papers that reflect the range of RFGES studies from single country papers to intra‐regional studies, to inter‐regional studies, and one global study.
Low prevalence of positive hydrogen breath tests in patients with functional gastrointestinal conditions and hypermobile Ehlers–Danlos syndrome
Authors: Dervin Humayra , Zarate‐Lopez Natalia , Sweis Rami , Mensah Alexia , Fragkos Konstantinos , Brugaletta Concetta , Raeburn Amanda , Emmanuel Anton 
Published: March 2023

AbstractBackgroundUsing hydrogen breath testing (HBT) to diagnose small intestinal bacterial overgrowth (SIBO) remains controversial in patients with functional gastrointestinal (GI) disorders, and unknown in those with hypermobility Ehlers–Danlos syndrome (hEDS). We assessed prevalence of positive HBTs in these groups, evaluated the predictive value of GI symptoms and the potential role of proton pump inhibitors (PPIs) on test results.MethodsSequential patients referred for HBT to a tertiary unit were classified into the following groups: GI maldigestion/malabsorption, GI sensorimotor disorders, hEDS, and functional GI disorders. All underwent standardized HBT, and the yield was assessed against symptoms and PPI use.Key ResultsA total of 1062 HBTs were performed over 3 years (70% female, mean age 48 ± 16 years). Overall, 7.5% (80/1062) patients had a positive HBT. Prevalence of positive HBT was highest in patients with GI maldigestion/malabsorption (17.9%; DOR 16.16, p < 0.001), GI sensorimotor disorders (15.9%; DOR 8.84, p < 0.001), compared to functional GI disorders (1.6%; DOR 1.0) (p < 0.0001). None of the hEDS patients tested positive for HBT. A positive HBT was independently associated with increased age (DOR 1.03; p < 0.001) and symptoms of diarrhea (DOR 3.95; p < 0.0001). Patients on PPIs tended towards a positive HBT than patients off PPIs (16.1% vs 6.9%; DOR 2.47; p < 0.0001).Conclusions & InferencesLess than 2% of patients with functional GI disorders, and none of the patients with hEDS had a positive HBT. Pre‐test probability was higher in patients with: GI structural or neurological disorders; use of long‐term PPIs and symptoms of diarrhea. These criteria may be helpful in making appropriate therapeutic decisions and avoiding unnecessary hydrogen breath testing.
Using a footstool does not aid simulated defecation in undifferentiated constipation: A randomized trial
Authors: Trieu Rose Qizhengyan , Prott Gillian , Sequeira Carol , Jones Michael , Mazor Yoav , Schnitzler Margaret , Malcolm Allison 
Published: March 2023

AbstractIntroductionThe use of a footstool has been advocated to optimize posture when sitting on the toilet and thus facilitate bowel evacuation. We aimed to assess the alterations in defecatory posture, and the changes in simulated defecation with use of a footstool in patients with constipation.MethodsForty‐one patients (female 93%, mean 52 year, SD 14 year) with constipation referred to a tertiary neurogastroenterology unit were enrolled. A bowel questionnaire, Hospital Anxiety and Depression Scale, and Rome questionnaire were administered prior to anorectal manometry. Each patient underwent three rectal balloon expulsion tests in randomized order with no footstool, a 7‐inch, and a 9‐inch footstool. Additional assessments included angle between spine and femur, and visual analogue scales assessing ease of evacuation, urge to defecate, and discomfort with expulsion.Key ResultsDefecatory posture was significantly altered by footstool use, with progressive narrowing of the angle between the spine and femur as footstool height increased (p < 0.001 for all comparisons). Compared with no footstool, the use of a footstool was not associated with a change in balloon expulsion time and there was no difference between the two footstool heights. Subjectively, no significant change was identified in any of the three perceptions of balloon expulsion between no footstool and footstool use.Conclusions and InferencesAlthough the use of a footstool led to changes in defecatory posture, it did not improve subjective or objective measures of simulated defecation in patients with undifferentiated constipation. Therefore, the recommendation for its use during evacuation cannot be applied to all patients with constipation.