bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining MYD88 L265P mutation detection and clonality determination on CSF cellular and cell‐free DNA improves diagnosis of primary CNS lymphoma
Authors: Bravetti Clotilde , Degaud Michaël , Armand Marine , Sourdeau Elise , Mokhtari Karima , Maloum Karim , Osman Jennifer , Verrier Patricia , Houillier Caroline , Roos‐Weil Damien , Soussain Carole , Choquet Sylvain , Hoang‐Xuan Khe , Le Garff‐Tavernier Magali , Denis Jérôme Alexandre , Davi Frédéric 
Published: March 2023

SummaryDiagnosis of primary central nervous system lymphoma (PCNSL) is challenging, and although brain biopsy remains the gold standard, cerebrospinal fluid (CSF) constitutes a less invasive source of lymphomatous biomarkers. In a retrospective cohort of 54 PCNSL cases tested at diagnosis or relapse, we evaluated the contribution of immunoglobulin heavy chain (IGH) gene clonality and MYD88 L265P detection on both CSF cell pellets and supernatants, in comparison with cytology, flow cytometry, interleukin (IL)‐10 and IL‐6 quantification. Clonality assessment included a new assay to detect partial IGH‐DJ rearrangements. Clonal IGH rearrangements and/or MYD88 L265P mutation were detected in 27 (50%) cell pellets and 24 (44%) supernatant cell‐free (cf) DNA. Combining analyses on both compartments, 36 (66%) cases had at least one detectable molecular marker, present only in cfDNA for 9 (16%) of them. While cytology and flow cytometry were positive in only 7 (13.0%) and 9 (17.3%) cases respectively, high IL‐10 levels were observed in 36 (66.7%) cases. Overall, taking into account molecular and cytokine results, 46/54 (85%) cases had at least one lymphomatous biomarker detectable in the CSF. These results show that this combination of biomarkers evaluated on both cell pellet and supernatant CSF fractions improves significantly the biological diagnosis of PCNSL.
The sleeping voices: Evaluating parenting ‘self‐help’ books, narratives of rule, routine and ritual
Authors: Scherer Lexie , Norman Amanda 
Published: March 2023

AbstractPutting children to bed is an everyday practice but is under‐studied in childhood research. Findings from this study of eight popular self‐help parenting books for 2‐to‐5‐year‐olds show that the books rarely, if ever, consider that children have voice/s, or social competence. Where the child does appear, it was to be silenced. Centrally, the authors push failure and responsibility onto parents. We found advice crystallised around either attachment‐led approaches, emphasising emotional availability, or behaviourist approaches. The discourses of sleep the books harness are professionalised external lenses. We explore the conflicting and sometimes contradictory ways they position children and families.
Spontaneous changes in brain network centrality in patients with pathological myopia: A voxel‐wise degree centrality analysis
Authors: Shi Wen‐Qing , Wei Hong , Kang Min , Zhang Li‐Juan , Xu San‐Hua , Ying Ping , Ling Qian , Pan Yi‐Cong , Huang Hui , Zou Jie , Shao Yi 
Published: March 2023

AbstractBackgroundMyopia has become a worldwide problem that endangers public health and adds a serious socioeconomic burden. Current research has focused on the pathogenesis and manifestations of pathological myopia (PM). However, few studies have been conducted on the spontaneous activity of the patient's brain.PurposeTo study the potential brain network activity in patients with PM by the degree centrality (DC) method.Materials and MethodsThis experiment included 15 PM patients and 15 healthy controls (HCs). Every participant experienced a resting‐state functional magnetic resonance imaging (rs‐fMRI) scan. Receiver operating characteristic (ROC) curve analysis was used to distinguish between PM patients and HCs. Correlation analysis was used to explore the relationships between mean DC values and clinical performance in different brain regions.ResultsIt showed that patients with PM had lower DC values in the right fusiform gyrus (FR) and right cingulate (CAR). The ROC curve was used to indicate the accuracy of the correlation. It showed that in PM group, left best corrected visual acuity (BCVA‐L) and right best corrected visual acuity (BCVA‐R) were negatively correlated with the DC value of FR.ConclusionThe occurrence of PM is mainly related to the abnormal activity of the fusiform and cingulum. DC value might be used as a biological marker of abnormal brain activity in PM patients.
Functional recovery continues beyond 3 months post‐basilar artery thrombectomy: A retrospective cohort study
Authors: Gunasekera Lakshini , Mitchell Peter , Dowling Richard J. , Bush Steven , Yan Bernard 
Published: March 2023

AbstractIntroductionUntreated basilar artery occlusion (BAO) carries 70% mortality. Guidelines recommend thrombectomy with or without thrombolysis.AimWe compared Modified Rankin Scores (mRS) at 3 and 12 months post thrombectomy to determine benefit of long‐term follow up.MethodsRetrospective, single centre analysis of BAO thrombectomies between 2015 and 2019. Inclusion criteria were symptomatic BAO on CT angiography, absent early ischemic changes, premorbid independence and intervention within 24 h. All received stroke ward care. Results were analysed with simple statistics and binary logistic regression as appropriate.ResultsOf 82 patients: most were male (61%, 50/82) with median age 68 years (IQR 17 years) and median NIHSS 14 (IQR 15). Median door‐to‐puncture time was 42 min (IQR 72 min). Total deaths were 34.1% (28/82) at 3 months, and 37.8% (31/82) at 12 months. Of 51 patients alive at 12 months: 41% (21/51) had improved mRS, 16% (8/51) had worse mRS and 43% (22/51) had unchanged mRS, compared to 3 months. Improvements to mRS were: one point in 57.1% (14/21), two points in 28.9% (6/21) and three points in 4.8% (1/21). Nursing home admission was avoided in 11.8% (6/51) who improved from mRS4. Increased age was associated with decreased likelihood of reaching the primary outcome OR 0.87, 95% CI 0.76–0.99 (p value = 0.03).ConclusionOver a quarter of patients improved beyond 3 months. Future studies should adopt long‐term follow up as primary outcome.
Altered functional connectivity of the default mode and frontal control networks in patients with insomnia
Authors: Zheng Hui , Zhou Qin , Yang Junjie , Lu Qian , Qiu Huaide , He Chuan , Yan Hailang 
Published: March 2023

AbstractAimsThe purpose of this study was to investigate the association between spontaneous regional activity and brain functional connectivity, which maybe can distinguish insomnia while being responsive to repetitive transcranial magnetic stimulation (rTMS) treatment effects in insomnia patients.MethodsUsing resting‐state functional magnetic resonance imaging data from 38 chronic insomnia patients and 36 healthy volunteers, we compared the amplitude of low‐frequency fluctuations (ALFF) between the two groups. Of all the patients with insomnia, 20 received rTMS for 4 weeks, while 18 patients received a 4‐week pseudo‐stimulation intervention. Seed‐based resting‐state functional connectivity (RSFC) analysis was conducted from regions with significantly different ALFF values, and the association between RSFC value and Pittsburgh Sleep Quality Index score was determined.ResultsOur results revealed that insomnia patients presented a significantly higher ALFF value in the posterior cingulate cortex (PCC), whereas a significantly lower ALFF value was observed in the superior parietal lobule (SPL). Moreover, significantly reduced RSFC was detected from both PCC to prefrontal cortex connections, as well as from left SPL to frontal pole connections. In addition, RSFC from frontal pole to left SPL negatively predicted sleep quality (PSQI) and treatment response in patients' group.ConclusionOur findings suggest that disrupted frontoparietal network connectivity may be a biomarker for insomnia in middle‐aged adults, reinforcing the potential of rTMS targeting the frontal lobes. Monitoring pretreatment RSFC could offer greater insight into how rTMS treatments are responded to by insomniacs.
Can ecological forecasting lead to convergence on sustainable lighting policies?
Authors: Burt Carolyn S. , Kelly Jeffrey F. , Fox Andrew S. , Jenkins‐Smith Hank C. , Leon‐Corwin Maggie , Khalighifar Ali , Trankina Grace E. , Silva Carol L. , Horton Kyle G. 
Published: March 2023

AbstractThe overuse and expansion of artificial light at night (ALAN) has emerged from complex social, economic, and political factors, making it a societal problem that negatively impacts wildlife and people. We propose that a convergence research approach combining ecological forecasting with community engagement and public policy is needed to address this diverse societal problem. To begin this convergence research approach, we hosted a workshop to strengthen connections among key biodiversity‐oriented ALAN stakeholders and to better understand how stakeholder groups function across the United States through facilitated discussions. We have prioritized the input of stakeholders early in our research design by including them in the formulation of a national survey on public perceptions surrounding ALAN and received their input on existing ecological forecasting tools to improve those research products for their future use.
Pyogenic liver abscesses in liver transplant recipients versus non‐transplant population. Outcome and risk factors of patient survival
Authors: Jiménez‐Romero Carlos , Marcacuzco Alberto , Caso Óscar , Lechuga Isabel , Manrique Alejandro , García‐Sesma Álvaro , Calvo Jorge , Aguado José María , López‐Medrano Francisco , Juan Rafael San , Justo Iago 
Published: March 2023

AbstractPyogenic liver abscess (PLA) is a life‐threatening infection in both liver transplant (LT) and non‐LT patients. Several risk factors, such as benign and malignant hepatopancreatobiliary diseases and colorectal tumors have been associated with PLA in the non‐LT population, and hepatic artery stricture/thrombosis, biliary stricture, and hepaticojejunostomy in the LT patients. The objective of this study is to compare the outcomes of patients with PLA in LT and non‐LT patients and to determine the risk factors associated with patient survival. From January 2000 to November 2020, a total of 296 adult patients were diagnosed of PLA in our institution, of whom 26 patients had previously undergone liver transplantation (LTA group), whereas 263 patients corresponded to the non‐LTA population. Seven patients with PLA who had undergone previous kidney transplantation were excluded from this retrospective study. Twenty‐six patients out of 1503 LT developed PLA (incidence of 1.7%). Median age was significantly higher in non‐LTA patients (p = .001). No significant differences were observed in therapy. PLA recurrence was significantly higher in LTA than in non‐LTA (34.6% vs. 14.8%; p = .008). In‐hospital mortality was greater in the LT group than in the non‐LT group (19.2% vs. 9.1% p = .10) and was identified in multivariable analysis as a risk factor for mortality (p = .027). Mortality rate during follow‐up did not show significant differences between the groups: 34.6% in LTA patients versus 26.2% in non‐LTA patients (p = .10). The most common causes of mortality during follow‐up were malignancies, Covid‐19 infection, and neurologic disease. 1‐, 3‐, and 5‐year actuarial patient survival rates were 87.0%, 64.1%, and 50.4%, respectively, in patients of LTA group, and 84.5%, 66.5%, and 51.0%, respectively, in patients with liver abscesses in non‐LTA population (p = .53). In conclusion, LT was a risk factor for in hospital mortality, but not during long‐term follow‐up.
Soil arthropod communities associated with Berberis thunbergii invasion in a temperate deciduous forest harbour more detritivores
Authors: Utz Ryan M. , Hart Ian S. , Rice Quentin 
Published: March 2023

Abstract
Barberry (Berberis thunbergii) is a widely established invasive shrub in temperate forests of the northeastern United States with the potential to alter soil arthropod communities through changes to soil nutrient cycling and acidity.
We compared soil arthropod taxa and functional feeding groups between invaded and nearby control areas in a paired observational survey.
Community ordination analysis suggested minimal differences between barberry and control samples. In contrast, pairwise differences revealed elevated densities of multiple taxa in barberry‐invaded soils.
Among taxa that were able to be defined by functional feeding group and were collected at higher densities under barberry, all were detritivores. For example, barberry‐invaded soils harboured an average of 40% more Isopoda and more than twice as many Diplopoda per unit dry compared with control samples. Differences we observed between barberry and control samples despite the limited study spatiotemporal scope demonstrate the potential for invasions to restructure soil arthropod communities.
Observed patterns potentially reflects elevated leaf litter decomposition rates associated with the invasion and results also highlight the need to integrate site‐specific environmental attributes when assessing the impact of invading plants on soil ecosystems.
SORD‐related peripheral neuropathy in a French and Swiss cohort: Clinical features, genetic analyses, and sorbitol dosages
Authors: Pons Nicolas , Fernández‐Eulate Gorka , Pegat Antoine , Théaudin Marie , Guieu Régis , Ripellino Paolo , Devedjian Manon , Mace Patrick , Masingue Marion , Léonard‐Louis Sarah , Petiot Philipe , Roche Pauline , Bernard Emilien , Bouhour Françoise , Good Jean‐Marc , Verschueren Annie , Grapperon Aude‐Marie , Salort Emmanuelle , Grosset Anaïs , Chanson Jean‐Baptiste , Nadaj‐Pakleza Aleksandra , Bédat‐Millet Anne‐Laure , Choumert Ariane , Barnier Anne , Hamdi Ghassen , Lesca Gaëtan , Prieur Fabienne , Bruneel Arnaud , Latour Philippe , Stojkovic Tanya , Attarian Shahram , Bonello‐Palot Nathalie 
Published: March 2023

AbstractBackground and purposeBiallelic variants in SORD have been reported as one of the main recessive causes for hereditary peripheral neuropathies such as Charcot–Marie–Tooth disease type 2 (CMT2) and distal hereditary motor neuropathy (dHMN) resulting in lower limb (LL) weakness and muscular atrophy. In this study, phenotype and genotype landscapes of SORD‐related peripheral neuropathies were described in a French and Swiss cohort. Serum sorbitol dosages were used to classify SORD variants.MethodsPatients followed at neuromuscular reference centres in France and Switzerland were ascertained. Sanger sequencing and next generation sequencing were performed to sequence SORD, and mass spectrometry was used to measure patients' serum sorbitol.ResultsThirty patients had SORD peripheral neuropathy associating LL weakness with muscular atrophy, foot deformities (87%), and sometimes proximal LL weakness (20%) or distal upper limb weakness (50%). Eighteen had dHMN, nine had CMT2, and three had intermediate CMT. Most of them had a mild or moderate disease severity. Sixteen carried a homozygous c.757delG (p.Ala253Glnfs*27) variant, and 11 carried compound heterozygous variants, among which four variants were not yet reported: c.403C > G, c.379G > A, c.68_100 + 1dup, and c.850dup. Two unrelated patients with different origins carried a homozygous c.458C > A variant, and one patient carried a new homozygous c.786 + 5G > A variant. Mean serum sorbitol levels were 17.01 mg/L ± 8.9 SD for patients carrying SORD variants.ConclusionsThis SORD‐inherited peripheral neuropathy cohort of 30 patients showed homogeneous clinical presentation and systematically elevated sorbitol levels (22‐fold) compared to controls, with both diagnostic and potential therapeutic implications.
Neural mechanisms of language development in infancy
Authors: Huberty Scott , O’Reilly Christian , Carter Leno Virginia , Steiman Mandy , Webb Sara , Elsabbagh Mayada ,   The BASIS Team
Published: March 2023

AbstractUnderstanding the neural processes underpinning individual differences in early language development is of increasing interest, as it is known to vary in typical development and to be quite heterogeneous in neurodevelopmental conditions. However, few studies to date have tested whether early brain measures are indicative of the developmental trajectory of language, as opposed to language outcomes at specific ages. We combined recordings from two longitudinal studies, including typically developing infants without a family history of autism, and infants with increased likelihood of developing autism (infant‐siblings) (N = 191). Electroencephalograms (EEG) were recorded at 6 months, and behavioral assessments at 6, 12, 18, 24 and 36 months of age. Using a growth curve model, we tested whether absolute EEG spectral power at 6 months was associated with concurrent language abilities, and developmental change in language between 6 and 36 months. We found evidence of an association between 6‐month alpha‐band power and concurrent, but not developmental change in, expressive language ability in both infant‐siblings and control infants. The observed association between 6‐month alpha‐band power and 6‐month expressive language was not moderated by group status, suggesting some continuity in neural mechanisms.
Research Review: Viewing self‐harm images on the internet and social media platforms: systematic review of the impact and associated psychological mechanisms
Authors: Susi Karima , Glover‐Ford Francesca , Stewart Anne , Knowles Bevis Rebecca , Hawton Keith 
Published: March 2023

BackgroundViewing self‐harm and suicide‐related images online can precede these behaviours. We reviewed studies of potential impacts and mechanisms associated with viewing self‐harm‐related images on the internet and social media.MethodCINAHL, Cochrane Library, EMBASE, HMIC, MEDLINE, PsycArticles, PsycINFO, PubMed, Scopus, Sociological Abstracts and Web of Science Core Collection databases were searched for relevant studies from inception to 22 January 2022. Inclusion criteria were English language, peer‐reviewed, empirical studies with data related to impacts of viewing self‐harm images or videos on the internet or social media. Quality and risk of bias were assessed using Critical Appraisal Skills Programme tools. A narrative synthesis approach was used.ResultsOf the 15 identified studies, all found harmful effects of viewing self‐harm‐related images online. These included escalation of self‐harm, reinforcement of engagement behaviours (e.g. commenting and sharing images), encouragement of social comparison (comparing own self‐harm with others), development of a self‐harm identity, social connection perpetuating or escalating self‐harm, and emotional, cognitive, and physiological impacts triggering self‐harm urges and acts. Nine studies found protective effects, including self‐harm mitigation or reduction, promotion of self‐harm recovery, encouraging social connection and help‐giving, and emotional, cognitive and physiological impacts mitigating or reducing self‐harm urges and acts. Causality of impact was not determined in any study. Most of the studies did not explicitly evaluate or discuss potential mechanisms.ConclusionsViewing self‐harm images online may have both harmful and protective effects, but harmful effects predominated in the studies. Clinically, it is important to assess individual's access to images relating to self‐harm and suicide, and the associated impacts, alongside pre‐existing vulnerabilities and contextual factors. Higher quality longitudinal research with less reliance on retrospective self‐report is needed, as well as studies that test potential mechanisms. We have developed a conceptual model of the impact of viewing self‐harm images online to inform future research.
A 7 day inpatient diabetes education program improves quality of life and glycemic control 12 months after discharge
Authors: Kurita Mika , Satoh Hiroaki , Kaga Hideyoshi , Kadowaki Satoshi , Someya Yuki , Tosaka Yuka , Nishida Yuya , Ikeda Fuki , Tamura Yoshifumi , Watada Hirotaka 
Published: March 2023

AbstractAimsFor long‐term management of diabetes, patients with type 2 diabetes mellitus require a high level of treatment adherence, which is associated with treatment satisfaction and their quality of life (QOL). To achieve it, patient education about diabetes self‐management is essential. We routinely conduct a 7 day inpatient diabetes education program and administer the diabetes treatment‐related (DTR)‐QOL questionnaire to all participants, both before admission and at discharge. Here, we investigated whether our program improves QOL and post‐discharge glycemic control.Materials and MethodsThis retrospective study utilized data from patients with type 2 diabetes mellitus who participated in our program between July 2017 and March 2020 and who had been treated in our outpatient department for more than 1 year. We evaluated the relationship between at admission and at discharge diabetes treatment‐related quality of life scores and glycemic control after discharge.ResultsData from 140 patients were analyzed in this study, which showed a significant improvement in the total, ‘Anxiety and dissatisfaction with treatment’, and ‘Satisfaction‐with‐treatment’ scores. A significant improvement was evident in HbA1c at 12 months after discharge. Multiple regression analysis showed that HbA1c after 12 months was independently associated with gender, duration of diabetes, and HbA1c at admission.ConclusionsOur program effectively improves quality of life and post‐discharge glycemic control in patients with type 2 diabetes mellitus. It is particularly effective in patients of the male gender, with a shorter duration of diabetes mellitus and higher HbA1c at admission.
2022 European guideline for the management of balanoposthitis
Authors: Edwards Sarah K. , Bunker Christopher B. , van der Snoek Eric M. , van der Meijden Willem I. 
Published: March 2023

AbstractBackgroundThis guideline is an update to the 2014 edition of the European guideline for the management of balanoposthitis. Balanoposthitis describes inflammation of the glans penis and prepuce and is caused by a range of disparate conditions including infection, dermatoses and premalignancy.ObjectiveThe main objectives of this guideline are to aid recognition of the symptoms and signs and complications of penile skin conditions and to offer recommendations on the diagnostic tests and treatment for a selected group of these conditions.MethodsThe previous guideline was updated following a literature review and priority was given to randomized controlled trial and systematic review evidence.ResultsThe updated guideline includes amended management for infective balanitis to provide clear guidance for Group A streptococcal infections, management of on going Lichen sclerosus (to include circumcision and supportive management to reduce the recurrence of genital herpes and warts), additional regimens for Zoonoid change, use of calcineurin inhibitors in management and risk of premalignancy and change of nomenclaturefrom Premalignant conditions to Penile Intraepithelial neoplasia (PeIN).ConclusionBalanoposthitis has a widerange of causes high quality evidence specific to the management of penile disease is not available for all the conditions described.