bluuebunny/crossref_metadata_2025_split huggingface dataset:
Domestic terrorism and leader survival, 1970–2014
Authors: Park Johann , Moon Chungshik 
Published: December 2022

AbstractRecent scholarly efforts to reveal the political effects of transnational terrorism are encouraging. They contribute to our understanding of how terrorism affects the targeted societies. We attempt to extend this line of research by examining the political impact of domestic terrorism. Domestic incidents overwhelmingly outnumber transnational incidents. In addition, the differences between domestic and transnational incidents may produce political outcomes. We examine the impact of domestic terrorism on the political survival of national leaders in the targeted societies. Our cross-national time-series analysis on a worldwide sample of 172 countries over the 1970–2014 period shows that domestic terrorism has a significant positive impact on leadership change. This impact is robust to various estimation techniques. This result suggests that heightened incidents of domestic terrorism hasten the removal of incumbent leaders in the targeted societies.
A low-profile two-arm backfire tapered cone helical antenna for TT&C in microsatellites
Authors: Kang Zhanyu , He Lianxing , Fei Dongliang , Li Mingkang , Liang Guang 
Published: December 2022

AbstractA novel low-profile two-arm backfire tapered cone helical antenna for telemetry tracking and command (TT&C) is introduced theoretically and experimentally in this paper. Compared with the conventional helical antenna, this design has a substantial decrease in its height and an increase both in its half power beamwidth (HPBW) and 3-dB axial ratio beamwidth by replacing the uniform structure with two tapered cone structures. It provides a maximum gain of 5.1 dBi, an excellent circular polarization radiation over a wide angular range of more than 124°, a 3-dB axial ratio bandwidth of 18.8%, a wide HPBW of more than 125°, and nearly equal E- and H- plane far-field patterns with high degree of axial symmetry over S-band (2–2.3 GHz). These excellent radiation characteristics with an endurable and compact structure make it an attractive candidate for TT&C application in microsatellite system, where the installation envelope and space for antenna are extremely limited.
An algorithm to reduce human–robot interface compliance errors in posture estimation in wearable robots
Authors: Koginov Gleb , Sternberg Kanako , Wolf Peter , Schmidt Kai , Duarte Jaime E. , Riener Robert 
Published: December 2022

Abstract
Assistive forces transmitted from wearable robots to the robot’s users are often defined by controllers that rely on the accurate estimation of the human posture. The compliant nature of the human–robot interface can negatively affect the robot’s ability to estimate the posture. In this article, we present a novel algorithm that uses machine learning to correct these errors in posture estimation. For that, we recorded motion capture data and robot performance data from a group of participants (n = 8; 4 females) who walked on a treadmill while wearing a wearable robot, the Myosuit. Participants walked on level ground at various gait speeds and levels of support from the Myosuit. We used optical motion capture data to measure the relative displacement between the person and the Myosuit. We then combined this data with data derived from the robot to train a model, using a grading boosting algorithm (XGBoost), that corrected for the mechanical compliance errors in posture estimation. For the Myosuit controller, we were particularly interested in the angle of the thigh segment. Using our algorithm, the estimated thigh segment’s angle RMS error was reduced from 6.3° (2.3°) to 2.5° (1.0°), mean (standard deviation). The average maximum error was reduced from 13.1° (4.9°) to 5.9° (2.1°). These improvements in posture estimation were observed for all of the considered assistance force levels and walking speeds. This suggests that ML-based algorithms provide a promising opportunity to be used in combination with wearable-robot sensors for an accurate user posture estimation.
Diverse Styles of Lithospheric Dripping: Synthesizing Gravitational Instability Models, Continental Tectonics, and Geologic Observations
Authors: McMillan Mitchell , Schoenbohm Lindsay M. 
Published: December 2022

AbstractDensity instabilities in the lithosphere can founder gravitationally via viscous dripping and decoupling from overlying crust. The lithospheric dripping concept has been invoked across the globe, but the diversity of crustal effects, observable evidence, and tectonic settings involved in dripping remain underexplored. Here, we synthesize numerical and analogue modeling studies and geologic data from the literature, including all proposed lithospheric dripping events to‐date. We argue that two distinct styles of dripping can occur depending on crustal strength (relative to that of the mantle lithosphere). Near‐surface contraction and subsidence of strong crusts contrasts with near‐surface extension and uplift of weak crusts. We discuss these events in terms of tectonic setting, timing, size, and the main types of data associated with each event. We also find that lithospheric dripping is associated with a distinct suite of geological observations including sedimentological, structural, volcanic, and geophysical data, which can be used to distinguish strong crusts from weak crusts. We find 27 events for which lithospheric dripping is a key hypothesis, including 9 with clear evidence for strong‐crust dripping and 3 with clear evidence of weak‐crust dripping. We review emerging research methods have the potential to detect the signals of dripping in the geologic and geophysical record, and we suggest additional techniques in light of our strong‐crust versus weak‐crust framework. The diverse tectonic settings and inferred consequences of these lithospheric drips, if confirmed, would demand a shift in our understanding of continental geology to emphasize the role of vertical removal of continental lithosphere.
Tracking the Evolution of an Ocean Within Mimas Using the Herschel Impact Basin
Authors: Denton C. A. , Rhoden A. R. 
Published: December 2022

AbstractMimas' small size, lack of geologic activity, and high eccentricity suggest a frozen, inactive history. However, Cassini libration measurements are best explained by a present‐day liquid ocean under an ice shell 24–31 km thick, a configuration that tidal heating can support. These unexpected findings have motivated further study of Mimas' surface geology to constrain its interior evolution. Here, we model the formation of Mimas' large impact basin, Herschel, using iSALE‐2D. Our goal is to determine whether the current estimated ice shell thickness is sufficient to withstand the impact and produce the observed basin morphology. We find that, if Mimas had an ocean at the time of the Herschel‐forming impact, the ice shell had to have been 10s of km thicker than today. These findings are consistent with inferences from minimal tectonic activity that Mimas must be a young ocean world, if it indeed has an ocean today.
SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis
Authors: Guo Saisai , Lei Xiaobo , Chang Yan , Zhao Jianyuan , Wang Jing , Dong Xiaojing , Liu Qian , Zhang Zixiong , Wang Lidan , Yi Dongrong , Ma Ling , Li Quanjie , Zhang Yongxin , Ding Jiwei , Liang Chen , Li Xiaoyu , Guo Fei , Wang Jianwei , Cen Shan 
Published: December 2022

AbstractThe coronavirus disease 2019 (COVID-19) pandemic has devastated global health. Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have been quested for the preparedness of future viral outbreaks. Here, we have identified host proteins that associate with nonstructural protein 12 (nsp12), the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 using a mass spectrometry (MS)-based proteomic approach. Among the candidate factors, CDK2 (Cyclin-dependent kinase 2), a member of cyclin-dependent kinases, interacts with nsp12 and causes its phosphorylation at T20, thus facilitating the assembly of the RdRp complex consisting of nsp12, nsp7 and nsp8 and promoting efficient synthesis of viral RNA. The crucial role of CDK2 in viral RdRp function is further supported by our observation that CDK2 inhibitors potently impair viral RNA synthesis and SARS-CoV-2 infection. Taken together, we have discovered CDK2 as a key host factor of SARS-CoV-2 RdRp complex, thus serving a promising target for the development of SARS-CoV-2 RdRp inhibitors.
4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer
Authors: Wang Yanan , Lei Jiapeng , Zhang Song , Wang Xiaomei , Jin Jiangbo , Liu Yufeng , Gan Mingxi , Yuan Yi , Sun Longhua , Li Xiaolei , Han Tianyu , Wang Jian-Bin 
Published: December 2022

AbstractNutrient-limiting conditions are common during cancer development. The coordination of cellular glucose levels and cell survival is a fundamental question in cell biology and has not been completely understood. 4EBP1 is known as a translational repressor to regulate cell proliferation and survival by controlling translation initiation, however, whether 4EBP1 could participate in tumor survival by other mechanism except for translational repression function, especially under glucose starvation conditions remains unknown. Here, we found that protein levels of 4EBP1 was up-regulated in the central region of the tumor which always suffered nutrient deprivation compared with the peripheral region. We further discovered that 4EBP1 was dephosphorylated by PTPMT1 under glucose starvation conditions, which prevented 4EBP1 from being targeted for ubiquitin-mediated proteasomal degradation by HERC5. After that, 4EBP1 translocated to cytoplasm and interacted with STAT3 by competing with JAK and ERK, leading to the inactivation of STAT3 in the cytoplasm, resulting in apoptosis under glucose withdrawal conditions. Moreover, 4EBP1 knockdown increased the tumor volume and weight in xenograft models by inhibiting apoptosis in the central region of tumor. These findings highlight a novel mechanism for 4EBP1 as a new cellular glucose sensor in regulating cancer cell death under glucose deprivation conditions, which was different from its classical function as a translational repressor.
Oriented intergrowth of the catalyst layer in membrane electrode assembly for alkaline water electrolysis
Authors: Wan Lei , Pang Maobin , Le Junfa , Xu Ziang , Zhou Hangyu , Xu Qin , Wang Baoguo 
Published: December 2022

AbstractThe application of membrane electrode assemblies is considered a promising approach for increasing the energy efficiency of conventional alkaline water electrolysis. However, previous investigations have mostly focused on improving membrane conductivity and electrocatalyst activity. This study reports an all-in-one membrane electrode assembly obtained by de novo design. The introduction of a porous membrane readily enables the oriented intergrowth of ordered catalyst layers using solvothermal methods, leading to the formation of an all-in-one MEA for alkaline water electrolysis. This all-in-one MEA features ordered catalyst layers with large surface areas, a low-tortuosity pore structure, integrated catalyst layer/membrane interfaces, and a well-ordered OH- transfer channel. Owing to this design, a high current density of 1000 mA cm−2 is obtained at 1.57 V in 30 wt% KOH, resulting in a 94% energy efficiency. This work highlights the prospects of all-in-one membrane electrode assemblies in designing next-generation high-performance alkaline water electrolysis.
Transition-metal free C–N bond formation from alkyl iodides and diazonium salts via halogen-atom transfer
Authors: Zhang Jing , Jiang Min , Wang Chang-Sheng , Guo Kai , Li Quan-Xin , Ma Cheng , Ni Shao-Fei , Chen Gen-Qiang , Zong Yan , Lu Hua , Xu Li-Wen , Shao Xinxin 
Published: December 2022

AbstractConstruction of C-N bond continues to be one part of the most significant goals in organic chemistry because of the universal applications of amines in pharmaceuticals, materials and agrochemicals. However, E2 elimination through classic SN2 substitution of alkyl halides lead to generation of alkenes as major side-products. Thus, formation of a challenging C(sp3)-N bond especially on tertiary carbon center remains highly desirable. Herein, we present a practical alternative to prepare primary, secondary and tertiary alkyl amines with high efficiency between alkyl iodides and easily accessible diazonium salts. This robust transformation only employs Cs2CO3 promoting halogen-atom transfer (XAT) process under transition-metal-free reaction conditions, thus providing a rapid method to assemble diverse C(sp3)-N bonds. Moreover, diazonium salts served as alkyl radical initiator and amination reagent in the reaction. Mechanism studies suggest this reaction undergo through halogen-atom transfer process to generate active alkyl radical which couples with diazonium cations to furnish final products.
Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses
Authors: Li Mingxi , Ren Yifei , Aw Zhen Qin , Chen Bo , Yang Ziqing , Lei Yuqing , Cheng Lin , Liang Qingtai , Hong Junxian , Yang Yiling , Chen Jing , Wong Yi Hao , Wei Jing , Shan Sisi , Zhang Senyan , Ge Jiwan , Wang Ruoke , Dong Jay Zengjun , Chen Yuxing , Shi Xuanling , Zhang Qi , Zhang Zheng , Chu Justin Jang Hann , Wang Xinquan , Zhang Linqi 
Published: December 2022

AbstractAs SARS-CoV-2 Omicron and other variants of concern (VOCs) continue spreading worldwide, development of antibodies and vaccines to confer broad and protective activity is a global priority. Here, we report on the identification of a special group of nanobodies from immunized alpaca with potency against diverse VOCs including Omicron subvariants BA.1, BA.2 and BA.4/5, SARS-CoV-1, and major sarbecoviruses. Crystal structure analysis of one representative nanobody, 3-2A2-4, discovers a highly conserved epitope located between the cryptic and the outer face of the receptor binding domain (RBD), distinctive from the receptor ACE2 binding site. Cryo-EM and biochemical evaluation reveal that 3-2A2-4 interferes structural alteration of RBD required for ACE2 binding. Passive delivery of 3-2A2-4 protects K18-hACE2 mice from infection of authentic SARS-CoV-2 Delta and Omicron. Identification of these unique nanobodies will inform the development of next generation antibody therapies and design of pan-sarbecovirus vaccines.
Active hydrogen boosts electrochemical nitrate reduction to ammonia
Authors: Fan Kui , Xie Wenfu , Li Jinze , Sun Yining , Xu Pengcheng , Tang Yang , Li Zhenhua , Shao Mingfei 
Published: December 2022

AbstractElectrochemical nitrate reduction to ammonia is a promising alternative strategy to the traditional Haber-Bosch process but suffers from a low Faradaic efficiency and limited ammonia yield due to the sluggish multi-electron/proton-involved steps. Herein, we report a typical hollow cobalt phosphide nanosphere electrocatalyst assembled on a self-supported carbon nanosheet array synthesized with a confinement strategy that exhibits an extremely high ammonia yield rate of 8.47 mmol h−1 cm−2 through nitrate reduction reaction, which is highly superior to previously reported values to our knowledge. In situ experiments and theoretical investigations reveal that the dynamic equilibrium between the generation of active hydrogen on cobalt phosphide and its timely consumption by nitrogen intermediates leads to a superior ammonia yield with a high Faradaic efficiency. This unique insight based on active hydrogen equilibrium provides new opportunities for large-scale ammonia production through electrochemical techniques and can be further used for carbon dioxide capture.
γ-BaFe2O4: a fresh playground for room temperature multiferroicity
Authors: Orlandi Fabio , Delmonte Davide , Calestani Gianluca , Cavalli Enrico , Gilioli Edmondo , Shvartsman Vladimir V. , Graziosi Patrizio , Rampino Stefano , Spaggiari Giulia , Liu Chao , Ren Wei , Picozzi Silvia , Solzi Massimo , Casappa Michele , Mezzadri Francesco 
Published: December 2022

AbstractMultiferroics, showing the coexistence of two or more ferroic orderings at room temperature, could harness a revolution in multifunctional devices. However, most of the multiferroic compounds known to date are not magnetically and electrically ordered at ambient conditions, so the discovery of new materials is pivotal to allow the development of the field. In this work, we show that BaFe2O4is a previously unrecognized room temperature multiferroic. X-ray and neutron diffraction allowed to reveal the polar crystal structure of the compound as well as its antiferromagnetic behavior, confirmed by bulk magnetometry characterizations. Piezo force microscopy and electrical measurements show the polarization to be switchable by the application of an external field, while symmetry analysis and calculations based on density functional theory reveal the improper nature of the ferroelectric component. Considering the present findings, we propose BaFe2O4as a Bi- and Pb-free model for the search of new advanced multiferroic materials.
High-frequency synthetic apomixis in hybrid rice
Authors: Vernet Aurore , Meynard Donaldo , Lian Qichao , Mieulet Delphine , Gibert Olivier , Bissah Matilda , Rivallan Ronan , Autran Daphné , Leblanc Olivier , Meunier Anne Cécile , Frouin Julien , Taillebois James , Shankle Kyle , Khanday Imtiyaz , Mercier Raphael , Sundaresan Venkatesan , Guiderdoni Emmanuel 
Published: December 2022

AbstractIntroducing asexual reproduction through seeds – apomixis – into crop species could revolutionize agriculture by allowing F1 hybrids with enhanced yield and stability to be clonally propagated. Engineering synthetic apomixis has proven feasible in inbred rice through the inactivation of three genes (MiMe), which results in the conversion of meiosis into mitosis in a line ectopically expressing the BABYBOOM1 (BBM1) parthenogenetic trigger in egg cells. However, only 10–30% of the seeds are clonal. Here, we show that synthetic apomixis can be achieved in an F1 hybrid of rice by inducing MiMe mutations and egg cell expression of BBM1 in a single step. We generate hybrid plants that produce more than 95% of clonal seeds across multiple generations. Clonal apomictic plants maintain the phenotype of the F1 hybrid along successive generations. Our results demonstrate that there is no barrier to almost fully penetrant synthetic apomixis in an important crop species, rendering it compatible with use in agriculture.
Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages
Authors: Feng Wei , Bais Abha , He Haoting , Rios Cassandra , Jiang Shan , Xu Juan , Chang Cindy , Kostka Dennis , Li Guang 
Published: December 2022

AbstractHeart development is a continuous process involving significant remodeling during embryogenesis and neonatal stages. To date, several groups have used single-cell sequencing to characterize the heart transcriptomes but failed to capture the progression of heart development at most stages. This has left gaps in understanding the contribution of each cell type across cardiac development. Here, we report the transcriptional profile of the murine heart from early embryogenesis to late neonatal stages. Through further analysis of this dataset, we identify several transcriptional features. We identify gene expression modules enriched at early embryonic and neonatal stages; multiple cell types in the left and right atriums are transcriptionally distinct at neonatal stages; many congenital heart defect-associated genes have cell type-specific expression; stage-unique ligand-receptor interactions are mostly between epicardial cells and other cell types at neonatal stages; and mutants of epicardium-expressed genesWt1andTbx18have different heart defects. Assessment of this dataset serves as an invaluable source of information for studies of heart development.
The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis
Authors: Lin Zhi , Liu Jiao , Long Fei , Kang Rui , Kroemer Guido , Tang Daolin , Yang Minghua 
Published: December 2022

AbstractFerroptosis is a type of regulated necrosis caused by unrestricted lipid peroxidation and subsequent plasma membrane rupture. However, the lipid remodeling mechanism that determines sensitivity to ferroptosis remains poorly understood. Here, we report a previously unrecognized role for the lipid flippase solute carrier family 47 member 1 (SLC47A1) as a regulator of lipid remodeling and survival during ferroptosis. Among 49 phospholipid scramblases, flippases, and floppases we analyzed, only SLC47A1 had mRNA that was selectively upregulated in multiple cancer cells exposed to ferroptotic inducers. Large-scale lipidomics and functional analyses revealed that the silencing of SLC47A1 increased RSL3- or erastin-induced ferroptosis by favoring ACSL4-SOAT1–mediated production of polyunsaturated fatty acid cholesterol esters. We identified peroxisome proliferator activated receptor alpha (PPARA) as a transcription factor that transactivates SLC47A1. The depletion of PPARA and SLC47A1 similarly sensitized cells to ferroptosis induction, whereas transfection-enforced re-expression of SLC47A1 restored resistance to ferroptosis in PPARA-deficient cells. Pharmacological or genetic blockade of the PPARA-SLC47A1 pathway increased the anticancer activity of a ferroptosis inducer in mice. These findings establish a direct molecular link between ferroptosis and lipid transporters, which may provide metabolic targets for overcoming drug resistance.
Emergence of the spin polarized domains in the kagome lattice Heisenberg antiferromagnet Zn-barlowite (Zn0.95Cu0.05)Cu3(OD)6FBr
Authors: Yuan Weishi , Wang Jiaming , Singer Philip M. , Smaha Rebecca W. , Wen Jiajia , Lee Young S. , Imai Takashi 
Published: December 2022

AbstractKagome lattice Heisenberg antiferromagnets are known to be highly sensitive to perturbations caused by the structural disorder. NMR is a local probe ideally suited for investigating such disorder-induced effects, but in practice, large distributions in the conventional one-dimensional NMR data make it difficult to distinguish the intrinsic behavior expected for pristine kagome quantum spin liquids from disorder-induced effects. Here we report the development of a two-dimensional NMR data acquisition scheme applied to Zn-barlowite (Zn0.95Cu0.05)Cu3(OD)6FBr kagome lattice, and successfully correlate the distribution of the low energy spin excitations with that of the local spin susceptibility. We present evidence for the gradual growth of domains with a local spin polarization induced by 5% Cu2+ defect spins occupying the interlayer non-magnetic Zn2+ sites. These spin-polarized domains account for ~60% of the sample volume at 2 K, where gapless excitations induced by interlayer defects dominate the low-energy sector of spin excitations within the kagome planes.