bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of pneumoconiosis in Zhejiang Province, China from 2006 to 2020: a descriptive study
Authors: Wei Fang , Xue Panqi , Zhou Lifang , Fang Xinglin , Zhang Yixin , Hu Yong , Zou Hua , Lou Xiaoming 
Published: February 2023

Abstract
Background
Pneumoconiosis is the most prevalent occupational disease and displays different patterns in each province of China. Clarifying specific incidence patterns and temporal trends in Zhejiang Province can help provide valuable information on the prevention of pneumoconiosis.

Methods
Annual reports of pneumoconiosis for Zhejiang Province from 2006 to 2020 were extracted from the National Occupational Disease and Occupational Health Information Monitoring System. The information of cases included regions, diagnosis ages, genders, exposure durations, pneumoconiosis categories and stages, the first year of exposure, enterprise industries, scales and ownerships.

Results
Totally 6037 new cases of pneumoconiosis were reported between 2006 and 2020, which increased at first and then gradually declined since 2013. Among all pneumoconiosis cases, silicosis accounted for the majority (72.17%). Most of the cases occurred in small-scale and domestic-funded enterprises, which accounted for 71.75% and 96.97%, respectively. When analyzing the industry distribution, the cases were mainly concentrated in mining (37.12%), manufacturing (31.11%) and ‘public administration and social organization’ (23.94%) industry. The average diagnosis age among the pneumoconiosis cases was 55.44 years, and the median exposure duration was 11.00 years. Significantly older diagnosis age and longer exposure duration were found in females, coal workers’ pneumoconiosis cases, cases with higher stages, cases with the first year of dust exposure earlier and cases from large-scale companies. In regional distribution, the top three cities reporting the most pneumoconiosis cases in Zhejiang Province were Taizhou, Quzhou and Hangzhou.

Conclusion
The current situation of pneumoconiosis in Zhejiang Province was still serious, and government should further strengthen the surveillance of occupational diseases and supervision of enterprises. Moreover, publicity and education regarding pneumoconiosis should be carried out to raise awareness of dust exposure risk and associated health consequences.
Rehabilitation approach in robot assisted total knee arthroplasty: an observational study
Authors: Scaturro Dalila , Vitagliani Fabio , Caracappa Dario , Tomasello Sofia , Chiaramonte Rita , Vecchio Michele , Camarda Lawrence , Mauro Giulia Letizia 
Published: February 2023

Abstract
Background
The purpose of this study is to evaluate the impact of total knee arthroplasty (TKA) with the aid of Navio Robot, comparing it with standard prosthetic surgery on the functional outcomes of patients after an intensive rehabilitation program.

Method
A case–control observational study was conducted on patients undergoing TKA for severe KOA. All patients underwent the same intensive hospital rehabilitation program of 14 daily sessions lasting 3 h. The following rating scales were administered: Numeric Rating Scale (NRS), Knee Society Score (KSS) and 12-Item Short Form Survey scale. Patient assessments were performed 1 week post-surgery (T0), 1 month post-surgery (T2), and 3 months post-surgery (T3). The primary outcomes were active knee extension and flexion and pain severity. The secondary outcomes were functional capacity and quality of life.

Results
Using repeated measures ANOVA, we observed at T1 a statistically different difference for the treatment group compared to the control group about KSS (p < 0.05), pain (p < 0.05), and knee flexion (p < 0.05). No statistically significant difference between the two groups was observed for knee extension (p = 0.09) and the SF-12 scale (p = 0.52). At T2 instead, we observed a statistically significant difference for the treatment group compared to the control group as regards KSS (p < 0.05) and knee flexion (p < 0.05), while no statistically significant difference was observed for pain (p = 0.83), knee extension (p = 0.60), and the SF-12 scale (0.44).

Conclusions
Our study has demonstrated that robot-NAVIO assisted knee prosthesis surgery, associated with a specific intensive rehabilitation treatment, in the short and medium term, determines good pain control, better flexion recovery and a improvement of functional capacity.
Diabetes remission of bariatric surgery and nonsurgical treatments in type 2 diabetes patients who failure to meet the criteria for surgery: a systematic review and meta-analysis
Authors: Zhou Xiaoying , Zeng Chunping 
Published: February 2023

Abstract
Background
The efficacy of bariatric surgery in moderate and severe obesity patients to reach diabetes remission is clear, but for mild obesity patients, the choice of surgical and non-surgical treatment is still unclear. This study we aim to compare the effect of surgical and nonsurgical treatment on patients BMI < 35 kg/m2 to reach diabetes remission.

Method
We searched relevant articles publish between Jan 1,2010 and Jan 1, 2023 in the following databases: Embase, PubMed/MEDLINE, Scopus, and Cochrane Library. We got the OR, MD and P-value using random effect model to compare the efficiency between bariatric surgery and nonsurgical treatment on diabetes remission, the reduction of BMI, Hb1Ac and FPG.

Results
In 7 included studies including 544 participants, bariatric surgery is more effective than non-surgical treatment to reach diabetes remission [OR 25.06, 95%CL 9.58–65.54]. Bariatric surgery more likely resulted in significant reductions in HbA1c [MD -1.44, 95%CL (-1.84)-(-1.04)] and FPG [MD -2.61, 95%CL (-3.20)-(-2.20)]. Bariatric surgery may resulted in reductions in BMI [MD -3.14, 95%CL (-4.41)-(-1.88)], which more significant in Asian.

Conclusion
In type 2 diabetes patients who BMI < 35 kg/m2, bariatric surgery is more likely to achieve diabetes remission and better blood glucose control than nonsurgical treatment.
Expression of EMT-related genes in lymph node metastasis in endometrial cancer: a TCGA-based study
Authors: Li He , Wang Junzhu , Li Liwei , Zhao Luyang , Wang Zhiqi 
Published: February 2023

Abstract

Background
Endometrial cancer (EC) with metastasis in pelvic/para-aortic lymph nodes suggests an unsatisfactory prognosis. Nevertheless, there is still rare literature focusing on the role of epithelial-mesenchymal transition (EMT) in lymph node metastasis (LNM) in EC.

Methods
Transcriptional data were derived from the TCGA database. Patients with stage IA–IIIC2 EC were included, constituting the LN-positive and LN-negative groups. To evaluate the extent of EMT, an EMT signature composed of 315 genes was adopted. The EMT-related genes (ERGs) were obtained from the dbEMT2 database, and the differentially expressed ERGs (DEERGs) between these two groups were screened. On the basis of DEERGs, pathway analysis was carried out. We eventually adopted the logistic regression model to build an ERG-based gene signature with predictive value for LNM in EC.

Results
A total of 498 patients were included, with 75 in the LN-positive group. Median EMT score of tumor tissues from LN-negative group was − 0.369, while that from the LN-positive group was − 0.296 (P < 0.001), which clearly exhibited a more mesenchymal phenotype for LNM cases on the EMT continuum. By comparing expression profiles, 266 genes were identified as DEERGs, in which 184 were upregulated and 82 were downregulated. In pathway analysis, various EMT-related pathways were enriched. DEERGs shared between molecular subtypes were comparatively few. The ROC curve and logistic regression analysis screened 7 genes with the best performance to distinguish between the LN-positive and LN-negative group, i.e., CIRBP, DDR1, F2RL2, HOXA10, PPARGC1A, SEMA3E, and TGFB1. A logistic regression model including the 7-gene-based risk score, age, grade, myometrial invasion, and histological subtype was built, with an AUC of 0.850 and a favorite calibration (P = 0.074). In the validation dataset composed of 83 EC patients, the model exhibited a satisfactory predictive value and was well-calibrated (P = 0.42).

Conclusion
The EMT status and expression of ERGs varied in LNM and non-LNM EC tissues, involving multiple EMT-related signaling pathways. Aside from that, the distribution of DEERGs differed among molecular subtypes. An ERG-based gene signature including 7 DEERGs exhibited a desirable predictive value for LNM in EC, which required further validation based upon clinical specimens in the future.
Identification and validation of a novel prognostic signature based on mitochondria and oxidative stress related genes for glioblastoma
Authors: Tong Shiao , Xia Minqi , Xu Yang , Sun Qian , Ye Liguo , Yuan Fanen , Wang Yixuan , Cai Jiayang , Ye Zhang , Tian Daofeng 
Published: February 2023

Abstract
Background
Mitochondria represent a major source of reactive oxygen species (ROS) in cells, and the direct increase in ROS content is the primary cause of oxidative stress, which plays an important role in tumor proliferation, invasion, angiogenesis, and treatment. However, the relationship between mitochondrial oxidative stress-related genes and glioblastoma (GBM) remains unclear. This study aimed to investigate the value of mitochondria and oxidative stress-related genes in the prognosis and therapeutic targets of GBM.

Methods
We retrieved mitochondria and oxidative stress-related genes from several public databases. The LASSO regression and Cox analyses were utilized to build a risk model and the ROC curve was used to assess its performance. Then, we analyzed the correlation between the model and immunity and mutation. Furthermore, CCK8 and EdU assays were utilized to verify the proliferative capacity of GBM cells and flow cytometry was used to analyze apoptosis rates. Finally, the JC-1 assay and ATP levels were utilized to detect mitochondrial function, and the intracellular ROS levels were determined using MitoSOX and BODIPY 581/591 C11.

Results
5 mitochondrial oxidative stress-related genes (CTSL, TXNRD2, NUDT1, STOX1, CYP2E1) were screened by differential expression analysis and Cox analysis and incorporated in a risk model which yielded a strong prediction accuracy (AUC value = 0.967). Furthermore, this model was strongly related to immune cell infiltration and mutation status and could identify potential targeted therapeutic drugs for GBM. Finally, we selected NUDT1 for further validation in vitro. The results showed that NUDT1 was elevated in GBM, and knockdown of NUDT1 inhibited the proliferation and induced apoptosis of GBM cells, while knockdown of NUDT1 damaged mitochondrial homeostasis and induced oxidative stress in GBM cells.

Conclusion
Our study was the first to propose a prognostic model of mitochondria and oxidative stress-related genes, which provided potential therapeutic strategies for GBM patients.
Contemplate iliosacral screw in patients with developmental dysplasia of the hip
Authors: Oztermeli Ahmet , Karahan Nazım , Aktan Ahmet 
Published: February 2023

Abstract
Objectives
Our aim in the study was evaluating sacroiliac morphology in patients with DDH and its possible effect on appropriate iliosacral screw fixation.

Design
Retrospective cohort study.

Setting
Level of evidence 3.

Patients/participants
We evaluated the anteroposterior pelvis X-ray and pelvic CT scans of patients. We mainly divided the patients into two groups: DDH group (n:105) and control group (n:105).

Intervention
The presence of the five qualitative characteristics of sacral dysplasia evaluated according to Route in both groups. The DDH group was divided into four subgroups according to the degree of hip dysplasia.

Main outcome measurement
The cross-sectional area, length of the osseous corridor, coronal and vertical angulation evaluated in both groups.

Results
The DDH group also exhibited a significantly higher S1 coronal and axial angulation, lower S1 cross-sectional area and S1 iliosacral screw length than the control group (p:0.033, p:0,002, p:0.006, p:0,019, respectively). According to the Rout classification, 9% were normal, 31% transient, 58% dysplastic in the DDH group. 45.7% were normal, 38% transient, 17% dysplastic in the control groups. These differences between the groups were statistically significant (p < 0.001). When the DDH groups were evaluated within themselves; no statistically significant difference was observed in S1 and S2 cross-sectional area, S1 and S2 maximum estimated iliosacral screw length, S1 and S2 axial and coronal angles assessment.

Conclusion
Sacral dysplasia was more common, narrower and more angled osseous canal for the iliosacral screw was found in the DDH group. There was no relation between the degree of hip dysplasia and sacrum morphology in the DDH group. Thus, we suggest the surgeons be aware of iatrogenic injury even in constrained dysplastic hips.
Overweight and obesity in adult patients with phenylketonuria: a systematic review
Authors: Tankeu Aurel T. , Pavlidou Despina Christina , Superti-Furga Andrea , Gariani Karim , Tran Christel 
Published: February 2023

Abstract
Background
Excess weight is a rising concern in patients with phenylketonuria (PKU). It is commonly observed in children and adolescents with PKU; but data on adults are inconsistent. This review aims to summarize available data on excess weight in adult PKU individuals.

Methods
We conducted a systematic search of literature in English, from inception to October 2021, on PubMed and Embase to identify articles on overweight and obesity in adult PKU patients. Prevalence of overweight and obesity, body mass index (BMI) and gender differences were the outcomes of interest.

Results
Of 260 articles identified, only 8 fulfilled quality criteria for inclusion after screening of titles, abstracts and full texts. The mean BMI of adult PKU patients in these studies ranged from 26 ± 5.4 to 30.3 ± 1.8 kg/m2. When compared to matched controls, adult PKU patients had higher BMI and higher prevalence of obesity. However, results were inconsistent when PKU adults were compared to the general population. The prevalence of obesity in the included studies varied widely between 4.5% up to 72% in individual studies. Obesity was 2–3 times more frequent in female PKU patients.

Conclusions
Excess weight is frequent in adult PKU patients, especially in females, even if the difference with the general population is debatable. The heterogeneity of the studies makes it difficult to interpret the results and the factors that contribute to obesity. Content of the diet, psychological status, diet-associated disordered eating, patient’s social environment and lifestyle are listed as potentials contributors to excess weight in PKU adult population. Further studies are needed to better elucidate this question. In the meantime, weight control and healthy eating habits should be considered in the management and follow-up of these patients.
BRAVEHeart: a randomised trial comparing the accuracy of Breathe Well and RPM for deep inspiration breath hold breast cancer radiotherapy
Authors: Byrne Hilary L. , Steiner Elisabeth , Booth Jeremy , Lamoury Gillian , Morgia Marita , Richardson Kylie , Ambrose Leigh , Makhija Kuldeep , Stanton Cameron , Zwan Benjamin , Bromley Regina , Atyeo John , Silvester Shona , Plant Natalie , Keall Paul 
Published: February 2023

Abstract
Background
Deep inspiration breath hold (DIBH) reduces radiotherapy cardiac dose for left-sided breast cancer patients. The primary aim of the BRAVEHeart (Breast Radiotherapy Audio Visual Enhancement for sparing the Heart) trial is to assess the accuracy and usability of a novel device, Breathe Well, for DIBH guidance for left-sided breast cancer patients. Breathe Well will be compared to an adapted widely available monitoring system, the Real-time Position Management system (RPM).

Methods
BRAVEHeart is a single institution prospective randomised trial of two DIBH devices. BRAVEHeart will assess the DIBH accuracy for Breathe Well and RPM during left-sided breast cancer radiotherapy. After informed consent has been obtained, 40 patients will be randomised into two equal groups, the experimental arm (Breathe Well) and the control arm (RPM with in-house modification of an added patient screen). The primary hypothesis of BRAVEHeart is that the accuracy of Breathe Well in maintaining the position of the chest during DIBH is superior to the RPM system. Accuracy will be measured by comparing chest wall motion extracted from images acquired of the treatment field during breast radiotherapy for patients treated using the Breathe Well system and those using the RPM system.

Discussion
The Breathe Well device uses a depth camera to monitor the chest surface while the RPM system monitors a block on the patient’s abdomen. The hypothesis of this trial is that the chest surface is a better surrogate for the internal chest wall motion used as a measure of treatment accuracy. The Breathe Well device aims to deliver an easy-to-use implementation of surface monitoring. The findings from the study will help inform the technology choice for other centres performing DIBH.

Trial registration
ClinicalTrials.govNCT02881203. Registered on 26 August 2016.
External load profile during different sport-specific activities in semi-professional soccer players
Authors: Pillitteri Guglielmo , Giustino Valerio , Petrucci Marco , Rossi Alessio , Bellafiore Marianna , Thomas Ewan , Iovane Angelo , Bianco Antonino , Palma Antonio , Battaglia Giuseppe 
Published: February 2023

Abstract
Background
Global Positioning System (GPS) devices are widely used in soccer for monitoring external load (EL) indicators with the aim of maximizing sports performance.The aim of this study was to investigate the EL indicators differences in players of different playing positions (i.e., central backs, external strikers, fullbacks, midfielders, strikers, wide midfielder) between and within different sport-specific tasks and official matches.

Methods
1932 observations from 28 semi-professional soccer players (age: 25 ± 6 years, height: 183 ± 6 cm, weight: 75.2 ± 7 kg) were collected through GPS devices (Qstarz BT-Q1000EX, 10 Hz) during the season 2019–2020. Participants were monitored during Official Match (OM), Friendly Matches (FM), Small Sided Games (SSG), and Match-Based Exercises (MBE). Metabolic (i.e., metabolic power, percentage of metabolic power > 35w, number of intense actions per minute, distance per minute, passive recovery time per minute) and neuromuscular indicators (i.e., percentage of intense accelerations, percentage of intense decelerations, change of direction per min > 30°) were recorded during each task.

Results
Statistically significant differences were detected in EL indicators between playing positions within each task and between tasks. In particular, results from the two-way ANOVA tests showed significant interaction, but with small effect size, in all the EL indicators between playing positions for each task and within tasks. Moreover, statistical differences, but with small effect size, between playing positions were detected in each task and for each EL indicator. Finally, the strongest statistical differences (with large effect size) were detected between tasks for each EL indicator. Details of the Tukey post-hoc analysis reporting the pairwise comparisons within and between tasks with playing positions are also provided.

Conclusion
In semi-professional soccer players, different metabolic and neuromuscular performance were detected in different playing position between and within different tasks and official matches. Coaches should consider the different physical responses related to different physical tasks and playing position to design the most appropriate training program.
Physical and cognitive function to explain the quality of life among older adults with cognitive impairment: exploring cognitive function as a mediator
Authors: Song Rhayun , Fan Xing , Seo Jisu 
Published: February 2023

AbstractBackgroundPhysical and cognitive function are both indicators of aging, characterized by a loss of adaptive response to life challenges and functional limitations, subsequently affecting their quality of life. This study aimed to identify the direct effect of physical function and the indirect effect of cognitive function on the quality of life in older adults with mild cognitive impairment.MethodsThe study participants were 79 older adults recruited from community centers in four urban districts of Korea. All participants completed a self-reported questionnaire for demographic characteristics and outcome variables. Outcome measures included physical function (grip strength, balance, and mobility), cognitive function, and mental and physical components of quality of life (QOL). Statistical analyses were conducted using hierarchical multiple linear regression and the PROCESS macro for mediation analysis.ResultsThe mean age of participants was 77.46 years old with an elementary or lower education level (53.2%). The mean score of cognitive function was 16.39 (SD = 6.5). Physical function (grip strength, balance, mobility) and cognitive function explained 25% of the variance in physical (p = 0.004) and 29% in mental (p < 0.001) components of QOL after controlling for age, sex, and education level. Mobility was associated with both physical (β=-0.27, p = 0.024) and mental (β=-0.36, p = 0.002) components of QOL. The cognitive function partially mediated the relationship between balance and the physical component of QOL; the proportion of mediation was 55%.ConclusionIn conclusion, physical and cognitive function were significant predictors of QOL in older adults with cognitive impairment. Specifically, balance has significant indirect effects on the physical component of QOL through cognitive function as a mediator. Health-promoting strategies could be more effective when focusing on the direct effect of physical function as well as the mediating effect of cognitive function to promote the quality of life in this population.
On the construct and perceptual validity measures of L1-based vs. L2-based elicitation as a measure of L2 classroom performance assessment
Authors: Mohammadi Darabad Ali , Abbasian Gholam-Reza , Mowlaie Bahram , Rostami Abusaeedi Ali-Asghar 
Published: February 2023

AbstractThis study aimed at investigating the English as a foreign language (EFL) learners’ perceptions of L1-based and L2-based elicitations in the English classroom employing an explanatory sequential mixed-method design. Ninety-seven Iranian intermediate EFL learners of English have been selected from Islamic Azad University (Science and Research Branch) in Tehran Province using a convenient sampling method. Of these, in the qualitative phase, 15 individuals were selected through a convenience sampling method as the focus group (N = 15; n = 8 for the L1 group and n = 7 for the L2 group). In the quantitative phase, 90 intermediate EFL learners were selected. The selected participants’ L2 performances were assessed through L1-based and L2-based elicitation techniques. They completed two validated researcher-made questionnaires to capture their perceptions of the elicitation techniques. Accordingly, five separate exploratory factor analyses were run to investigate the underlying constructs of the five components of the L1-based and L2-based perception questionnaires, the results of which showed that the correlation matrices were not singular and there were perfect correlations among all variables of L1-based and L2-based perception questionnaires. The findings show that the majority of respondents prefer to use their L2 in speaking classes and believe that L2 should be the prior language in general speaking classes. More than two-thirds of the respondents prefer to use L2 when they want to communicate with each other inside and outside of the classroom and prefer to use L2 in doing their assignments or performing orally in class. More than half of the respondents prefer to use L2 in assessment sessions.