bluuebunny/crossref_metadata_2025_split huggingface dataset:
A global perspective of soil-forming conditions during the Late Pennsylvanian: potential stochastic forcing by geosphere–biosphere carbon pools
Authors: Gulbranson Erik L. , Tabor Neil J. 
Published: December 2022

Abstract

The Kasimovian was a time of ecological upheaval and large-magnitude changes in palaeoclimate. Referred to as the ‘collapse’ of the palaeotropical rainforests, the Kasimovian is marked by rapid changes in megafloral communities and associated ecosystem effects on vertebrates and invertebrates.
p
CO
2
variation coincided with these ecological catastrophes, varying between pre-industrial levels (PAL) to 2×PAL on 10
5
year timescales. Our understanding of the carbon cycle perturbations that affected
p
CO
2
and the connection of these climate-forcings to the terrestrial upheaval of palaeotropical rainforests remains a grand challenge. Here, the effects of palaeosol accumulation and/or degradation on the terrestrial carbon cycle during the Kasimovian is assessed. Palaeosols are surveyed from ice-free depositional basins on Pangaea and assessed for palaeolandscape equilibrium. An orbital framework is developed in order to understand the relationships of palaeosols, the carbon cycle, and insolation. Based on these analyses a key time interval emerges in the early Kasimovian. This time interval records a shift in palaeolandscape equilibria, terrestrial carbon cycling, and orbital forcing. The carbon cycling and landscape equilibria are eccentricity-paced; however, predominance of short eccentricity and obliquity throughout this interval indicates that the changes to palaeosols and the locus of carbon burial may have acted as a stochastic process.
MPEG Visual Quality Assessment Advisory Group
Authors: Wien Mathias 
Published: December 2022

The perceived visual quality is of utmost importance in the context of visual media compression, such as 2D, 3D, immersive video, and point clouds. The trade-off between compression efficiency and computational/implementation complexity has a crucial impact on the success of a compression scheme. This specifically holds for the development of visual media compression standards which typically aims at maximum compression efficiency using state-of-the-art coding technology. In MPEG, the subjective and objective assessment of visual quality has always been an integral part of the standards development process. Due to the significant effort of formal subjective evaluations, the standardization process typically relies on such formal tests in the starting phase and for verification while in the development phase objective metrics are used. In the new MPEG structure, established in 2020, a dedicated advisory group has been installed for the purpose of providing, maintaining, and developing visual quality assessment methods suitable for use in the standardization process.
This column lays out the scope and tasks of this advisory group and reports on its first achievements and developments. After a brief overview of the organizational structure, current projects are presented, and initial results are presented.
Scientia Potentia Est—On the Role of Knowledge in Computational Argumentation
Authors: Lauscher Anne , Wachsmuth Henning , Gurevych Iryna , Glavaš Goran 
Published: December 2022

Abstract
Despite extensive research efforts in recent years, computational argumentation (CA) remains one of the most challenging areas of natural language processing. The reason for this is the inherent complexity of the cognitive processes behind human argumentation, which integrate a plethora of different types of knowledge, ranging from topic-specific facts and common sense to rhetorical knowledge. The integration of knowledge from such a wide range in CA requires modeling capabilities far beyond many other natural language understanding tasks. Existing research on mining, assessing, reasoning over, and generating arguments largely acknowledges that much more knowledge is needed to accurately model argumentation computationally. However, a systematic overview of the types of knowledge introduced in existing CA models is missing, hindering targeted progress in the field. Adopting the operational definition of knowledge as any task-relevant normative information not provided as input, the survey paper at hand fills this gap by (1) proposing a taxonomy of types of knowledge required in CA tasks, (2) systematizing the large body of CA work according to the reliance on and exploitation of these knowledge types for the four main research areas in CA, and (3) outlining and discussing directions for future research efforts in CA.
Objective Communication Patterns Associated With Team Member Effectiveness in Real-World Virtual Teams
Authors: O’Bryan Lisa , Oxendahl Tim , Chen Xu , McDuff Daniel , Segarra Santiago , Wettergreen Matthew , Beier Margaret E. , Sabharwal Ashutosh 
Published: December 2022

Objective We explore the relationships between objective communication patterns displayed during virtual team meetings and established, qualitative measures of team member effectiveness. Background A key component of teamwork is communication. Automated measures of objective communication patterns are becoming more feasible and offer the ability to measure and monitor communication in a scalable, consistent and continuous manner. However, their validity in reflecting meaningful measures of teamwork processes are not well established, especially in real-world settings. Method We studied real-world virtual student teams working on semester-long projects. We captured virtual team meetings using the Zoom video conferencing platform throughout the semester and periodic surveys comprising peer ratings of team member effectiveness. Leveraging audio transcripts, we examined relationships between objective measures of speaking time, silence gap duration and vocal turn-taking and peer ratings of team member effectiveness. Results Speaking time, speaking turn count, degree centrality and (marginally) speaking turn duration, but not silence gap duration, were positively related to individual-level team member effectiveness. Time in dyadic interactions and interaction count, but not interaction length, were positively related to dyad-level team member effectiveness. Conclusion Our study highlights the relevance of objective measures of speaking time and vocal turn-taking to team member effectiveness in virtual project-based teams, supporting the validity of these objective measures and their use in future research. Application Our approach offers a scalable, easy-to-use method for measuring communication patterns and team member effectiveness in virtual teams and opens the opportunity to study these patterns in a more continuous and dynamic manner.
Nutritional, biochemical, and clinical determinants of hyperuricemia in systemic lupus erythematosus patients: Relationship with clinical and renal disease activity
Authors: Campos-López Bertha , Meza-Meza Mónica R , Pesqueda-Cendejas Karen , Ruiz-Ballesteros Adolfo I , Rivera-Escoto Melissa , Vargas-Morales Juan M , Parra-Rojas Isela , Mora-García Paulina E , Vizmanos Barbara , Montoya-Buelna Margarita , Cerpa-Cruz Sergio , De la Cruz-Mosso Ulises 
Published: December 2022

Systemic lupus erythematosus (SLE) is the prototypical autoimmune disease considered as an independent risk factor for mortality by cardiovascular disease. Currently, uric acid is described as a novel biomarker associated with cardiometabolic risk. However, nutritional and serum determinants that influence hyperuricemia development in autoimmune diseases have not been fully elucidated. This study aimed to assess the nutritional, biochemical, and cardiometabolic determinants of hyperuricemia and its relationship with clinical variables in SLE patients. A cross-sectional study was conducted in 167 SLE patients and 195 control subjects (CS). Nutrient intake, anthropometry, biochemical, and cardiometabolic indexes were evaluated. In SLE patients, adequate protein (OR = 0.4; p = 0.04) and carbohydrate (OR = 0.2; p = 0.01) intakes were associated with a lower risk of hyperuricemia. SLE patients with hyperuricemia presented a higher risk of clinical (OR = 2.2; p = 0.03) and renal activity (OR = 3.4; p < 0.01), as well as triglycerides ≥150 mg/dL (OR = 3.6; p < 0.01), hs-CRP ≥1 mg/L (OR = 3.1; p < 0.01), Kannel score ≥3 (OR = 2.5; p = 0.02), and BMI ≥25 kg/m2 (OR = 2.2; p = 0.02). Oppositely, serum levels of HDL-C ≥40 mg/dL (OR = 0.2; p < 0.01) were associated with a lower risk of hyperuricemia. According to the pharmacotherapy administered, prednisone treatment was associated with a high risk of hyperuricemia (OR = 4.7; p < 0.001). In contrast, the hydroxychloroquine treatment was associated with a lower risk of hyperuricemia (OR = 0.4; p = 0.02). In conclusion, SLE patients with hyperuricemia presented a high risk of clinical and renal activity as well as worse cardiometabolic status. Notably, an adequate intake of protein, carbohydrates, healthy HDL-C serum levels, and hydroxychloroquine treatment could be determinants of lower risk of hyperuricemia.
Correction of orbital implant exposure using a supra-brow island flap pedicled with orbicularis oculi muscle
Authors: Zhang Zhenzhen , Ye Xinhai 
Published: December 2022

Purpose To describe our experience of the supra-brow island flap pedicled with orbicularis oculi muscle technique for correcting orbit implant exposure. Materials and methods This retrospective study reviewed 32 patients that underwent orbit implant exposure surgery using a supra-brow island flap pedicled with orbicularis oculi muscle. All data were reviewed from patients in Eye & ENT Hospital of Fudan University, Shanghai during January 2018 to July 2020. The patient demographics, the original etiology, surgical procedures, implant types, and follow-up interval were recorded. The primary outcome was the long-term coverage of the supra-brow island flap pedicled with orbicularis oculi muscle, and the post-surgical complications and management were secondary outcomes. Results 28 eyes of 28 patients had functional results and satisfactory cosmetic outcomes at final follow up(range, 9–29 months). Among the other 4 patients, the recurrence of exposure was recorded during the follow-up, two of these patients successfully underwent dermis fat grafts(DFGs), one recovered after conservative treatment, and one refused treatment. Conclusions The supra-brow island flap pedicled with orbicularis oculi muscle is a technique available to manage orbital implant exposure when other simpler and more direct techniques have been tried and failed. Precis A new flap for orbital implant exposure
Nordic paradox in action: The complicated relation between social mobility and health inequalities in an international comparative study
Authors: Consolazio David , Sarti Simone , Terraneo Marco 
Published: December 2022

Aims: Socio-economic inequalities originate from several channels, one of which is family origins, with clear effects on people’s health. This paper aims to evaluate the role played by social mobility in determining health inequalities, relying on Blau and Duncan’s status attainment model and focusing specifically on two moments of social reproduction of inequalities: one inter-generational, based on the transmission of resources from the family of origin, the other intra-generational, related to the capitalisation of economic resources to maximise well-being. Methods: Multi-group models of structural equations were used to examine the direct and indirect effects of parental cultural background, education and economic conditions of respondents on self-perceived health in 28 countries, relying on the European Social Survey ( N=38,879). Results: Overall, the results confirmed the presence of an inter-generational transmission of social and health status. Different models of transmission of health inequalities emerged among the countries considered. Countries characterised by a social democratic welfare regime showed higher social mobility and fewer health inequalities, although in correspondence with a prominent role of economic factors in determining health conditions. On the other hand, in countries where social mobility is lower, health inequalities are more pronounced, yet driven by factors others than economics, such as socio-cultural origins. Conclusions: The presence of a higher economic-health gradient in social democratic countries – notwithstanding their egalitarian and universal welfare policies – provides support for the existence of a Nordic paradox in relation to health inequalities.
Tacrolimus Formulation, Exposure Variability, and Outcomes in Kidney Transplant Recipients
Authors: Lai Elaine F. , Nguyen Huong Thao , Famure Olusegun , Li Yanhong , Kim S. Joseph 
Published: December 2022

Introduction Few studies have compared within-patient variability measures of tacrolimus trough levels by formulation and assessed within-patient variability on outcomes of kidney transplant recipients. Research Questions (1) To compare within-patient variability of trough levels when converting from twice-daily to once-daily tacrolimus using standard deviation, coefficient of variation, and intrapatient variability percent. (2) To use the 3 measures of variability to examine the relationship between tacrolimus once-daily within-patient variability and total graft failure (i.e., return to chronic dialysis, pre-emptive retransplant, death with graft function). Design In this observational cohort study, within-patient variability of trough levels pre- and post-conversion from twice-daily to once-daily tacrolimus were compared using Wilcoxon matched-pairs signed-rank test. Graft outcomes were analyzed using Kaplan-Meier curves and multivariable Cox proportional hazards models. Results In 463 patients, within-patient variability differences pre- and post-conversion of median standard deviation, coefficient of variation, and intrapatient variability percent were −0.16 ( P = 0.09), −0.01 ( P = 0.52), and −1.41 ( P = 0.32), respectively. Post-conversion, every 1 unit increase in within-patient variability standard deviation and intrapatient variability percent and every 0.1 unit increase in the coefficient of variation was associated with an increased hazard ratio [1.19 ( P = 0.004), 1.02 ( P = 0.030), 1.13 ( P = 0.001), respectively] of total graft failure. Post-conversion, within-patient variability above cohort medians using standard deviation and coefficient of variation had a significantly higher risk of total graft failure. Discussion Under a program-wide conversion, no significant difference was observed in within-patient variability post-conversion from twice-daily to once-daily tacrolimus using the three measures of variability. High within-patient variability was associated with adverse transplant outcomes post-conversion.
Polysorbate 80 blocked a peripheral sodium channel, Nav1.7, and reduced neuronal excitability
Authors: Kim Ryeong-Eun , Choi Jin-Sung 
Published: December 2022

Polysorbate 80 is a non-ionic detergent derived from polyethoxylated sorbitan and oleic acid. It is widely used in pharmaceuticals, foods, and cosmetics as an emulsifier. Nav1.7 is a peripheral sodium channel that is highly expressed in sympathetic and sensory neurons, and it plays a critical role in determining the threshold of action potentials (APs). We found that 10 μg/mL polysorbate 80 either abolished APs or increased the threshold of the APs of dorsal root ganglions. We thus investigated whether polysorbate 80 inhibits Nav1.7 sodium current using a whole-cell patch-clamp recording technique. Polysorbate 80 decreased the Nav1.7 current in a concentration-dependent manner with a half-maximal inhibitory concentration (IC50) of 250.4 μg/mL at a holding potential of −120 mV. However, the IC50 was 1.1 μg/mL at a holding potential of −90 mV and was estimated to be 0.9 μg/mL at the resting potentials of neurons, where most channels are inactivated. The activation rate and the voltage dependency of activation of Nav1.7 were not changed by polysorbate 80. However, polysorbate 80 caused hyperpolarizing shifts in the voltage dependency of the steady-state fast inactivation curve. The blocking of Nav1.7 currents by polysorbate 80 was not reversible at a holding potential of −90 mV but was completely reversible at −120 mV, where the channels were mostly in the closed state. Polysorbate 80 also slowed recovery from inactivation and induced robust use-dependent inhibition, indicating that it is likely to bind to and stabilize the inactivated state. Our results indicate that polysorbate 80 inhibits Nav1.7 current in concentration-, state-, and use-dependent manners when used even below commercial concentrations. This suggests that polysorbate 80 may be helpful in pain medicine as an excipient. In addition, in vitro experiments using polysorbate 80 with neurons should be conducted with caution.
Carboplasty, a Simple Tibial Marrow Technique for Knee Osteoarthritis: A Placebo-Controlled Randomized Trial
Authors: Madrazo-Ibarra Antonio , Barve Raghav , Carroll Kaitlin M. , Proner Robert , Topar Christoper , Ibarra Clemente , Coleman Struan H. , Vad Vijay 
Published: December 2022

Background: Carboplasty is a new minimally invasive technique for knee osteoarthritis (OA) that consists of injecting tibial marrow aspirate into the bone-cartilage interface as well as intra-articularly. Purpose: To compare the clinical and imaging outcomes, as well as the safety, of carboplasty for symptomatic knee OA in a placebo-controlled trial. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: The authors conducted a randomized controlled trial to compare carboplasty with placebo for the treatment of symptomatic knee OA. Patients who had failed medical treatment and had bone edema on magnetic resonance imaging (MRI) were randomized in a 1:1 ratio to carboplasty or placebo. The primary outcome of the study was the Numeric Pain Rating Scale (NPRS) for the knee at 1 year (scores range from 0 to 10, with a higher score indicating worse pain). Secondary outcomes were the Knee injury and Osteoarthritis Outcome Score (KOOS), treatment responder rate (based on achieving the minimal clinically important difference of the NPRS), MRI bone edema reduction, and treatment safety. Results: In total, 50 patients (25 carboplasty vs 25 placebo) were enrolled and followed up with for an average of 18 months (range, 14-24 months). The average NPRS at baseline decreased from 7.1 ± 0.9 to 2.9 ± 2.1 ( P < .001) at 1 year in the carboplasty group and from 7.7 ± 0.9 to 4.9 ± 2.2 ( P < .001) in the placebo group. On average, patients after carboplasty improved 60% from their initial NPRS, and patients after placebo improved 37% ( P = .003). Patients had a statistically significantly greater improvement from baseline in all KOOS subscales in the carboplasty group compared with the placebo group ( P < .001). The responder rates were 96% for carboplasty and 76% for placebo ( P = .098). Bone edema was reduced in 72% of patients in the carboplasty group and 44% of patients in the placebo group ( P = .045). Neither group had adverse events related to treatment. Conclusion: Carboplasty resulted in greater pain reduction, a significantly greater improvement in all KOOS subscales, and a similar safety profile compared with placebo in patients with symptomatic knee OA and bone edema. Registration: ISRCTN69838191 (ISRCT Registry).
Comparison of the effectiveness and safety of direct oral anticoagulants: a nationwide propensity score–weighted study
Authors: Ingason Arnar B. , Hreinsson Johann P. , Agustsson Arnar S. , Lund Sigrun H. , Rumba Edward , Palsson Daniel A. , Reynisson Indridi E. , Gudmundsdottir Brynja R. , Onundarson Pall T. , Bjornsson Einar S. 
Published: December 2022

Abstract
In the pivotal randomized controlled trials (RCTs) for patients with atrial fibrillation, direct oral anticoagulants (DOACs) had similar or even superior efficacy and safety compared with warfarin. However, RCTs comparing different DOACs are nonexistent and previous observational studies have yielded conflicting results. In this nationwide cohort study, rates of any stroke or systemic embolism (stroke/SE) and major bleeding were compared among new users of apixaban, dabigatran, and rivaroxaban with atrial fibrillation from 2014 to 2019. Inverse probability weighting was used to yield balanced study groups, and outcomes were compared using Cox regression. Stroke/SE rates were similar in patients receiving apixaban, dabigatran, and rivaroxaban. Dabigatran was associated with twofold higher rates of myocardial infarction (MI) than rivaroxaban (1.4 events/100 person-years (py) vs 0.7 events/100-py, hazard ratio [HR] 2.21, 95% confidence interval [CI], 1.00-4.90) and apixaban (1.4 events/100-py vs 0.7 events/100-py, HR 2.26, 95% CI, 0.90-5.67), although the second comparison included the possibility of a null effect. Rivaroxaban was associated with higher major bleeding rates compared with apixaban (2.9 events/100-py vs 1.8 events/100-py, HR 1.64, 95% CI, 1.13-2.37) and dabigatran (2.9 events/100-py vs 1.4 events/100-py, HR 2.18, 95% CI, 1.21-3.93). Specifically, rivaroxaban had higher rates of major gastrointestinal bleeding and other major bleeding than apixaban. In conclusion, although stroke/SE rates were similar for DOACs, rivaroxaban was associated with higher rates of major bleeding than other DOACs and lower rates of MI than dabigatran. These results may help guide oral anticoagulant selection, especially in patients at high risk of bleeding or MI.
Digital surveillance in Latin American diseases outbreaks: information extraction from a novel Spanish corpus
Authors: Dellanzo Antonella , Cotik Viviana , Lozano Barriga Daniel Yunior , Mollapaza Apaza Jonathan Jimmy , Palomino Daniel , Schiaffino Fernando , Yanque Aliaga Alexander , Ochoa-Luna José 
Published: December 2022

Abstract
Background
In order to detect threats to public health and to be well-prepared for endemic and pandemic illness outbreaks, countries usually rely on event-based surveillance (EBS) and indicator-based surveillance systems. Event-based surveillance systems are key components of early warning systems and focus on fast capturing of data to detect threat signals through channels other than traditional surveillance. In this study, we develop Natural Language Processing tools that can be used within EBS systems. In particular, we focus on information extraction techniques that enable digital surveillance to monitor Internet data and social media.

Results
We created an annotated Spanish corpus from ProMED-mail health reports regarding disease outbreaks in Latin America. The corpus has been used to train algorithms for two information extraction tasks: named entity recognition and relation extraction. The algorithms, based on deep learning and rules, have been applied to recognize diseases, hosts, and geographical locations where a disease is occurring, among other entities and relations. In addition, an in-depth analysis of micro-average F1 metrics shows the suitability of our approaches for both tasks.

Conclusions
The annotated corpus and algorithms presented could leverage the development of automated tools for extracting information from news and health reports written in Spanish. Moreover, this framework could be useful within EBS systems to support the early detection of Latin American disease outbreaks.