bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of built environment and socio-economic factors on commuting energy demand. A path analysis-based approach
Authors: Boukarta Soufiane , Berezowska-Azzag Ewa 
Published: January 2023

Transport is the second energy consumer sector after housing in Algeria. In this article, we explore the ener- gy implication of commuting by considering a panel of socio-economic (SE) and built environment (BE) driving factors. The method is based on four steps: (i) The first step is to identify the main and potential drivers from the literature review and to propose a model that summarises the main assumptions that could explain the volume of commuting and the resulting energy consumption. (ii) In the second step, we designed and distributed 700 questionnaires in the municipality of Djelfa and retained 184 valid questionnaires in the final study sample. (iii) In the third step, we developed a method adapted to urban areas to quantify energy consumption as a function of the distance travelled, the type and density of occupation by means of transport and the type of fuel. (iv) The fourth step is to check the fit of the hypothetical model with a path analysis-based approach. The model developed identifies 15 factors, of which five have a direct impact and 10 have an indirect impact on the energy consumption of commuting. The model shows that building density and the age of the respondent can reduce the energy consumption of commuting by up to −15% and
−12% respectively; whereas the number of cars by housing and the round-trip frequency could increase the energy consumption up to 38% and 27% respectively. Our results suggest a structuring role of the socio-economic characteristics of households in explaining the energy consumption of commuting.
Safely correct hyponatremia with continuous renal replacement therapy: A flexible, all‐purpose method based on the mixing paradigm
Authors: Chen Sheldon , Yee Jerry , Chiaramonte Robert 
Published: January 2023

AbstractTreating chronic hyponatremia by continuous renal replacement therapy (CRRT) is challenging because the gradient between a replacement fluid's [sodium] and a patient's serum sodium can be steep, risking too rapid of a correction rate with possible consequences. Besides CRRT, other gains and losses of sodium‐ and potassium‐containing solutions, like intravenous fluid and urine output, affect the correction of serum sodium over time, known as osmotherapy. The way these fluids interact and contribute to the sodium/potassium/water balance can be parsed as a mixing problem. As Na/K/H2O are added, mixed in the body, and drained via CRRT, the net balance of solutes must be related to the change in serum sodium, expressible as a differential equation. Its solution has many variables, one of which is the sodium correction rate, but all variables can be evaluated by a root‐finding technique. The mixing paradigm is proved to replicate the established equations of osmotherapy, as in the special case of a steady volume. The flexibility to solve for any variable broadens our treatment options. If the pre‐filter replacement fluid cannot be diluted, then we can compensate by calculating the CRRT blood flow rate needed. Or we can deduce the infusion rate of dextrose 5% water, post‐filter, to appropriately slow the rise in serum sodium. In conclusion, the mixing model is a generalizable and practical tool to analyze patient scenarios of greater complexity than before, to help doctors customize a CRRT prescription to safely and effectively reach the serum sodium target.
Weibull model for RUL estimation at RSG-GAS reactor implemented on PA01-AP01 secondary pump
Authors: Sudadiyo Sri 
Published: January 2023

Abstract
Remaining Useful Life (RUL) estimation has been extensively explored in recent years. RUL could be used in deciding the maintenance timeline or inspection interval for the Reaktor Serba Guna – G. A. Siwabessy (RSG-GAS reactor). RSG-GAS reactor is a pool-type research reactor (built by the Interatom Internationale of Germany) and has been operating for more than 30 years to date. This study aimed to propose a Weibull model to find the RUL estimation value of the distribution parameters of the mean time to failure (MTTF). Therefore, the RSG-GAS reactor would be higher safety, longer lifetime and higher reliability with a smaller failure rate including for the PA01-AP01 secondary pump. The research methodology is processing data collection and estimating the parameters of the Weibull model to determine maintenance timeline or inspection intervals based on the MTTF value in case the reliability has reached the targeted percentage. Results show that the RUL estimation has been obtained for the RSG-GAS reactor. In the implemented study, a maintenance timeline has been stipulated for the PA01-AP01 secondary pump (with the model of KSB and type of CPK-S350-400) for the reliability of 90% and RUL estimation of circa 29 days.
A Unique Role for Protocadherin γC3 in Promoting Dendrite Arborization through an Axin1-Dependent Mechanism
Authors: Steffen David M. , Hanes Camille M. , Mah Kar Men , Valiño Ramos Paula , Bosch Peter J. , Hinz Dalton C. , Radley Jason J. , Burgess Robert W. , Garrett Andrew M. , Weiner Joshua A. 
Published: January 2023

The establishment of a functional cerebral cortex depends on the proper execution of multiple developmental steps, culminating in dendritic and axonal outgrowth and the formation and maturation of synaptic connections. Dysregulation of these processes can result in improper neuronal connectivity, including that associated with various neurodevelopmental disorders. The γ-Protocadherins (γ-Pcdhs), a family of 22 distinct cell adhesion molecules that share a C-terminal cytoplasmic domain, are involved in multiple aspects of neurodevelopment including neuronal survival, dendrite arborization, and synapse development. The extent to which individual γ-Pcdh family members play unique versus common roles remains unclear. We demonstrated previously that the γ-Pcdh-C3 isoform (γC3), via its unique “variable” cytoplasmic domain (VCD), interacts in cultured cells with Axin1, a Wnt-pathway scaffold protein that regulates the differentiation and morphology of neurons. Here, we confirm that γC3 and Axin1 interact in the cortexin vivoand show that both male and female mice specifically lacking γC3 exhibit disrupted Axin1 localization to synaptic fractions, without obvious changes in dendritic spine density or morphology. However, both male and female γC3 knock-out mice exhibit severely decreased dendritic complexity of cortical pyramidal neurons that is not observed in mouse lines lacking several other γ-Pcdh isoforms. Combining knock-out with rescue constructs in cultured cortical neurons pooled from both male and female mice, we show that γC3 promotes dendritic arborization through an Axin1-dependent mechanism mediated through its VCD. Together, these data identify a novel mechanism through which γC3 uniquely regulates the formation of cortical circuitry.SIGNIFICANCE STATEMENTThe complexity of a neuron's dendritic arbor is critical for its function. We showed previously that the γ-Protocadherin (γ-Pcdh) family of 22 cell adhesion molecules promotes arborization during development; it remained unclear whether individual family members played unique roles. Here, we show that one γ-Pcdh isoform, γC3, interacts in the brain with Axin1, a scaffolding protein known to influence dendrite development. A CRISPR/Cas9-generated mutant mouse line lacking γC3 (but not lines lacking other γ-Pcdhs) exhibits severely reduced dendritic complexity of cerebral cortex neurons. Using cultured γC3 knock-out neurons and a variety of rescue constructs, we confirm that the γC3 cytoplasmic domain promotes arborization through an Axin1-dependent mechanism. Thus, γ-Pcdh isoforms are not interchangeable, but rather can play unique neurodevelopmental roles.
A Novel and Functionally Diverse Class of Acetylcholine-Gated Ion Channels
Authors: Hardege Iris , Morud Julia , Courtney Amy , Schafer William R. 
Published: January 2023

Fast cholinergic neurotransmission is mediated by acetylcholine-gated ion channels; in particular, excitatory nicotinic acetylcholine receptors play well established roles in virtually all nervous systems. Acetylcholine-gated inhibitory channels have also been identified in some invertebrate phyla, yet their roles in the nervous system are less well understood. We report the existence of multiple new inhibitory ion channels with diverse ligand activation properties inCaenorhabditis elegans. We identify three channels, LGC-40, LGC-57, and LGC-58, whose primary ligand is choline rather than acetylcholine, as well as the first evidence of a truly polymodal channel, LGC-39, which is activated by both cholinergic and aminergic ligands. Using our new ligand–receptor pairs we uncover the surprising extent to which single neurons in the hermaphrodite nervous system express both excitatory and inhibitory channels, not only for acetylcholine but also for the other major neurotransmitters. The results presented in this study offer new insight into the potential evolutionary benefit of a vast and diverse repertoire of ligand-gated ion channels to generate complexity in an anatomically compact nervous system.SIGNIFICANCE STATEMENTHere we describe the diversity of cholinergic signaling in the nematodeCaenorhabditis elegans. We identify and characterize a novel family of ligand-gated ion channels and show that they are preferentially gated by choline rather than acetylcholine and expressed broadly in the nervous system. Interestingly, we also identify one channel gated by chemically diverse ligands including acetylcholine and aminergic ligands. By using our new knowledge of these ligand-gated ion channels, we built a model to predict the synaptic polarity in theC. elegansconnectome. This model can be used for generating hypotheses on neural circuit function.
Values Education through the Exemplary of Sultan Syarif Kasim II for Students in Riau
Authors: Pernantah Piki Setri , Ahmal Ahmal 
Published: January 2023

Education of values through the example of a figure who is also a national hero from Riau is still lacking. It is necessary to have values education based on historical figures so that students cannot forget their heroes and imitate Sultan Syarif Kasim II’s struggles. This research was conducted using a qualitative method with a descriptive-analytical approach. The values reconstructed from the results of field research and literature studies are then integrated into the historical student learning at the University of Riau so that it is internalized into students who will later become self-character based on the fighting spirit of the heroes of Riau. Pendidikan nilai melalui keteladanan sosok yang juga merupakan pahlawan nasional asal Riau masih sangat kurang. Perlu adanya pendidikan nilai berbasis tokoh sejarah agar mahasiswa tidak melupakan pahlawannya sehingga mampu meneladani perjuangan yang telah dilakukan Sultan Syarif Kasim II. Penelitian ini dilakukan dengan menggunakan metode kualitatif dengan pendekatan deskriptif-analitis. Nilai-nilai yang telah direkonstruksi dari hasil penelitian lapangan dan studi literatur tersebut kemudian diintegrasikan ke dalam perkuliahan sejarah lokal mahasiswa sejarah Universitas Riau. Sehingga terinternalisasi ke dalam diri mahasiswa yang nantinya menjadi karakter diri yang dilandasi semangat perjuangan para pahlawan Riau. Cite this article: Pernantah, P.S., Ahmal. (2022). Values Education through the Exemplary of Sultan Syarif Kasim II for Students in Riau. Paramita: Historical Studies Journal, 32(2), 276-285. http://dx.doi.org/10.15294/paramita.v32i2.27632
Validity and Effectiveness of the Historical Electronics Module for Senior High School
Authors: Najuah Najuah , Sidiq Ricu , Azhari Ichwan , Lukitoyo Pristi Suhendro 
Published: January 2023

This study examines the content validity and presentation of historical electronics modules (HEM) based on higher-order thinking skills developed with the ADDIE model for class XII high school students in Indonesia. In addition, the assessment of the effectiveness of the module on improving critical and analytical thinking skills through a competency test. The research method used is a mixed-method with research and development and experimental designs, starting from the development of the electronic history module and starting from Analysis, Design, Development, Implementation, and Evaluation. The results showed that the validity of the content and presentation from the experts and the users, in this case, students were very valid, so HEM was very suitable. The effectiveness test results showed increased students’ ability to think critically and analytically as an indicator of higher-order thinking. The electronic developed with a higher-order thinking approach can improve students’ ability to think critically and analytically in learning history independently. Penelitian ini mengkaji validitas isi dan penyajian modul elektronika sejarah (HEM) berbasis kemampuan berpikir tingkat tinggi yang dikembangkan dengan model ADDIE untuk siswa kelas XII SMA di Indonesia. Selain itu, penilaian keefektifan modul terhadap peningkatan kemampuan berpikir kritis dan analitis melalui uji kompetensi. Metode penelitian yang digunakan adalah metode campuran dengan desain penelitian dan pengembangan dan eksperimen, dimulai dari pengembangan modul sejarah elektronika) mulai dari Analisis, Perancangan, Pengembangan, Implementasi, dan Evaluasi. Hasil penelitian menunjukkan bahwa validitas isi dan penyajian dari ahli dan pengguna dalam hal ini siswa sangat valid, sehingga HEM sangat sesuai. Hasil uji efektivitas menunjukkan peningkatan kemampuan berpikir kritis dan analitis siswa sebagai indikator berpikir tingkat tinggi. Elektronik yang dikembangkan dengan pendekatan berpikir tingkat tinggi dapat meningkatkan kemampuan siswa untuk berpikir kritis dan analitis dalam pembelajaran sejarah secara mandiri. Cite this article: Najuah, Sidiq, R., Azhari, I., Lukitoyo, P.S. (2022). Validity and Effectiveness of the Historical Electronics Module for Senior High School. Paramita: Historical Studies Journal, 32(2), 286-294. http://dx.doi.org/10.15294/paramita.v32i2.30576
The Use of Economic Geography Theory in the Study of City History, a Methodological Thinking
Authors: Hartatik Endah Sri 
Published: January 2023

The study of city history requires auxiliary science to explain socio-economic phenomena. One of the essential auxiliary sciences is Geography. This article aims to describe a theoretical analysis of economic geography concepts and theories that can be used to analyze historical phenomena that discuss space as a factor in social phenomena. The research method used is a literature study based on relevant scientific books and journals. The results show that the theory and concept of geography can clarify historical researchers in discussing urban spatial phenomena related to various aspects of social phenomena, primarily the phenomenon of economic development. The images of the geographic theory that can be used are the theory of transportation networks, linkage theory, network theory or “networks,” and agglomeration theory. Through theoretical clarity, one can understand social phenomena in historical situations at a certain period more clearly than narrative studies based solely on historical sources. Kajian sejarah kota memerlukan ilmu bantu untuk menjelaskan fenomena fenomena sosial-ekonomi. Salah satu ilmu bantu penting adalah Geografi. Artikel ini bertujuan untuk memaparkan kajian teoretik konsep dan teori Geografi ekonomi yang dapat digunakan untuk menganalisis fenomena sejarah yang membahas keruangan sebagai faktor fenomena sosial. Metode penelitian yang digunakan adalah studi pustaka dengan mendasarkan pada buku dan jurnal ilmiah yang relevan. Hasil penelitian menunjukkkan bahwa teori dan konsep Geografi dapat memperjelas peneliti sejarah dalam membahas fenomena keruangan kota yang terkait dengan berbagai aspek fenomena sosial, terutama fenomena perkembangan ekonomi. Konsep dari teori geografi yang dapat digunakan adalah teori tentang jaringan transportasi, teore linkage, teori jaringan atau “networks’, dan teori aglomerasi. Melalu kejelasan teoretik maka fenomena sosial dalam situasi sejarah pada periode tertentu dapat dipahami lebih jelas dibandingkan dengan kajian naratif semata yang mendasarkan pada sumber-sumber sejarah. Cite this article: Hartatik, E.S. (2022). The Use of Economic Geography Theory in the Study of City History, a Methodological Thinking. Paramita: Historical Studies Journal, 32(2), 191-201. http://dx.doi.org/10.15294/paramita.v32i2.35611
Childhood use of coin pusher and crane grab machines, and adult gambling: A conceptual replication of Newall et al. (2021)
Authors: Parrado-González Alberto , Newall Philip W.S. 
Published: January 2023

AbstractBackground and aimsYouth gambling research mainly focuses on the illegal use of age-restricted machines, but coin pusher and crane grab machines are gambling machines that can be used by people of any age in the UK, and are also in use internationally. Previous cross-sectional evidence has associated recollected childhood usage of these machines with adult gambling participation and levels of problem gambling amongst adult gamblers. We attempted to conceptually replicate the findings of one of these studies (Newall et al., 2021), while addressing some limitations of that study.MethodsA cross-sectional survey of 2,000 UK-based and -born participants aged 19–24 years. The measures were participants' recollected usage of coin pusher and crane grab machines as a child, whether they had gambled in the past 12-months or not, and the PGSI for past 12-month gamblers.ResultsOverall, 5 of 7 tested associations were significant and in the hypothesized direction. Logistic regression models showed that adult gamblers were more likely to recollect using, and used at higher levels of frequency, coin pusher and crane grab machines, than non-gamblers. Then, negative binomial regression analysis showed that adults who recollected using crane grab machines at higher levels of frequency showed more gambling-related problems.Discussion and ConclusionsThese results suggest that childhood usage of coin pusher and crane grab machines may act as an underappreciated risk factor for the development of gambling-related harm across the lifespan. This information may be considered for further youth gambling research and policy.
Efficient degradation of 4-nitrophenol using VO(TPP) impregnated TiO2 photocatalyst: Insight into kinetics and mechanism
Authors: Yadav Vandana , Verma Priyanka , Negi Himani , Singh Raj Kumar , Saini Vipin Kumar 
Published: January 2023

AbstractHeterogeneous composites of metalloporphyrins with TiO2 possess exceptional photosensitizing properties, which works efficiently in degradation of organic pollutants. Herein, vanadium porphyrin complex {VO(TPP)} was loaded on TiO2 photocatalyst {VO(TPP)–TiO2} by the wet impregnation method. The as-prepared catalysts were characterized to analyze physicochemical properties and the photocatalytic degradation of 4-nitrophenol (4-NP) was investigated to assess their catalytic efficiency. XRD results revealed that VO(TPP)–TiO2 is dual-phase anatase/rutile with high crystallinity. The UV-DRS study showed that the loading of {VO(TPP)} on TiO2 caused a red-shift in the absorption spectrum and decreased the band-gap as well. The surface area has increased significantly after impregnation as confirmed by BET isotherm. The degradation of 4-NP follows pseudo-first-order kinetics, and the VO(TPP)–TiO2 showed higher degradation (99%) of 4-NP as compared to pure TiO2 (87%). The degradation mechanism of 4-NP and its pathway was also discussed using UV–Vis spectroscopy and electrospray mass spectrometry analysis.
Graphical abstract
Powder metallurgical processing of Al matrix composite reinforced with AlSiCrMnFeNiCu high-entropy alloys: Microstructure, thermal stability, and microhardness
Authors: Shadangi Yagnesh , Chattopadhyay Kausik , Mukhopadhyay Nilay Krishna 
Published: January 2023

AbstractThe present work deals with powder metallurgical processing of AA 6082 Al matrix composite reinforced with non-equiatomic AlSiCrMnFeNiCu high-entropy alloy (HEA). The structure, microstructure, morphology, and phase composition of these Al-HEA nanocomposite powders were discerned through XRD and TEM, SEM–EDS, respectively. The AlSiCrMnFeNiCu HEA used as reinforcement was found to have a two-phase microstructure with a major and minor fraction corresponding to the B2-type (a = 0.29 nm; cP2) and Cr5Si3-type (a = b = 0.9165 nm, c = 0.4638 nm; tI32) phases, respectively. Mechanical milling (MM) imparts significant refinement, and nanostructuring of grains (~ 10–12 nm) for Al-HEA for nanocomposite powder was observed. These powders of Al-HEA was found to be thermally stable up to 650 ℃. Further, these Al-HEA nanocomposite powders were consolidated through pressure-less sintering at 560 ℃, which led to the formation of a thin ~ 400–500 nm transitional layer at the interface. The microhardness of these Al-HEA composites were tuned in the range of ~ 0.90 to 1.81 GPa.
Graphical abstract
Communication Strategy on Agricultural Insurance in South Kalimantan
Authors: Alif Muhammad , . Sumardjo , Sarwoprasodjo Sarwititi , Fatchiya Anna 
Published: January 2023

This study aims to analyze the communication strategy of the agricultural insurance program in the South Kalimantan region to create superior and independent farmers. This communication strategy can contribute to the existing development program in South Kalimantan. Qualitative methods with SWOT and TOWS analysis techniques were employed in this study. Data collection techniques included open interviews, focus group discussions (FGD), and field observations (research location and district level). The results show that agricultural insurance in South Kalimantan still has obstacles that occur in the field. Many farmers do not understand and are interested in participating in this rice farming insurance. The communication strategy can include increasing the capacity and quality of government human resources in the field by providing technical socialization training; involving community leaders, farmer groups, and village government in disseminating information; optimizing social capital in the community; establishing an information center at the village level; increase the variety and diversity of information delivery methods carried out by extension agents and Jasindo officers; as well as providing various media for various sources of information, especially social media and the internet