bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunogenicity and efficacy of serogroup A and D bacterins against Pasteurella multocida in mice
Authors: Guan Li-jun , Yang Jin-qian , Xu Qing-yuan , Feng Yi-fan , Zhang Xi-chen , Tang Bo , Zhao Zhan-qin 
Published: March 2023

IntroductionPasteurella multocida is a widespread respiratory pathogen in pigs, causing swine pneumonia and atrophic rhinitis, and the capsular serogroups A and D are the main epidemic serogroups in infected animals. This study investigated the protective effects of serogroup A and D bacterins against current circulating P. multocida strains, to better understand the immunity generated by bacterins.Method13 serogroup A (seven A: L3 and six A: L6 strains) and 13 serogroup D (all D: L6 strains) P. multocida strains were isolated, and used as inactivated whole cell antigen to prepare P. multocida bacterins. Mice were immunized with these bacterins at 21-day interval and intraperitoneally challenged with the homologous and heterologous P. multocida strains, respectively. The antibody titer levels and immunization protective efficacy of vaccines were evaluated.ResultsAll of the bacterins tested induced high titer levels of immunoglobulin G antibodies against the parental bacterial antigen in mice. Vaccination with the six A: L6 bacterins provided no protection against the parent strain, but some strains did provide heterologous protection against A: L3 strains. Vaccination with the seven A: L3 bacterins provided 50%–100% protection against the parent strain, but none gave heterologous protection against the A:L6 strains. Immunization with the thirteen D: L6 bacterins offered 60%–100% protection against the parent strain, and almost all D: L6 strains gave cross-protection.DiscussionThis study found that the cross-protectivity of serogroup A strains was poor, while serogroup D strains was effective, which provided some insights for P. multocida vaccine development.
Phytochemicals, Antioxidant and Antimicrobial Potentials and LC-MS Analysis of Centaurea parviflora Desf. Extracts
Authors: Hechaichi Fatima Zohra , Bendif Hamdi , Bensouici Chawki , Alsalamah Sulaiman A. , Zaidi Boutheina , Bouhenna Mustapha Mounir , Souilah Nabila , Alghonaim Mohammed I. , Benslama Abderrahim , Medjekal Samir , Qurtam Ashraf A. , Miara Mohamed Djamel , Boufahja Fehmi 
Published: March 2023

Centaurea parviflora (C. parviflora), belonging to the family Asteraceae, is an Algerian medicinal plant used in folk medicine to treat different diseases related to hyperglycemic and inflammatory disorders, as well as in food. The present study aimed to assess the total phenolic content, in vitro antioxidant and antimicrobial activity and phytochemical profile of the extracts of C. parviflora. The extraction of phenolic compounds from aerial parts was conducted using solvents of increasing polarity starting from methanol, resulting in crude extract (CE), to chloroform extract (CHE), ethyl acetate extract (EAE) and butanol extract (BUE). The total phenolic, flavonoid and flavonol contents of the extracts were determined using the Folin–Ciocalteu and AlCl3 methods, respectively. The antioxidant activity was measured with seven methods: 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, galvinoxyl free-radical-scavenging test, 2,2′-Azino-Bis(3-Ethylbenzothiazoline-6-Sulfonic Acid) (ABTS) assay, cupric reducing antioxidant capacity (CUPRAC), reducing power, Fe+2-phenanthroline reduction assay and superoxide-scavenging test. The disc-diffusion method aimed at testing the sensitivity of bacterial strains toward our extracts. A qualitative analysis with thin-layer chromatography of the methanolic extract was performed. Moreover, HPLC-DAD-MS was used to establish the phytochemical profile of the BUE. The BUE was found to contain high amounts of total phenolics (175.27 ± 2.79 µg GAE/mg E), flavonoids (59.89 ± 0.91 µg QE/mg E) and flavonols (47.30 ± 0.51 µg RE/mg E). Using TLC, different components such as flavonoids and polyphenols were noted. The highest radical-scavenging ability was recorded for the BUE against DPPH (IC50 = 59.38 ± 0.72 µg/mL), galvinoxyl (IC50 = 36.25 ± 0.42 µg/mL), ABTS (IC50 = 49.52 ± 1.54 µg/mL) and superoxide (IC50 = 13.61 ± 0.38 µg/mL). The BUE had the best reducing power according to the CUPRAC (A0.5 = 71.80 ± 1.22 μg/mL), phenanthroline test (A0.5 = 20.29 ± 1.16 μg/mL) and FRAP (A0.5 = 119.17 ± 0.29 μg/mL). The LC-MS analysis of BUE allowed us to identify eight compounds including six phenolic acids and two flavonoids: quinic acid, five chlorogenic acid derivatives, rutin and quercetin 3-o-glucoside. This preliminary investigation revealed that the extracts of C. parviflora have a good biopharmaceutical activity. The BUE possesses an interesting potential for pharmaceutical/nutraceutical applications.
Analisis Kepuasan Konsumen terhadap Loyalitas Konsumen dengan Dimoderasi oleh Faktor Harga dan Variasi Produk Makanan Sehat pada PT Melia Sehat Sejahtera
Authors: Nasution Amrin Mulia Utama 
Published: March 2023

Many providers in Indonesia currently have many products such as PT Melia Sehat Sejahtera. The success of product development has made PT Melia Sehat Sejahtera a well-known in Indonesia. The many awards this has won has made PT Melia Sehat Sejahtera always be number one thanks to the level of customer loyalty. Consumer loyalty according to behavioral understanding is consistent with repurchasing behavior as well as a measure of customer preference to repurchase and the tendency to switch to the product. Repurchase intention is strongly influenced by consumer satisfaction with a product. However, there are two studies which state that it has a negative effect on consumer loyalty, so that a moderating variable appears. This research was tested on 133 respondents who then collected the data and tested its feasibility. After the feasibility test, a data analysis test was carried out using SEM (regression) with the help of the SmartPLS program. This study resulted in the following conclusions 1) The strong role of consumer satisfaction (93%) on consumer loyalty at PT Melia Sehat Sejahtera, because PT Melia Sehat Sejahtera is a highly recommended place to eat with its food choices, PT Melia Sehat Sejahtera is also easy to get, with many branches in each region make it easier for consumers to buy PT Melia Sehat Sejahtera products. 2) Consumer satisfaction which is moderated by the price of PT Melia Sehat Sejahtera's products has a relatively small effect (1%) on consumer loyalty and price can also play a direct negative role (-1.3%) on consumer loyalty. This is because the price is competitive compared to similar products. 3) The role of the relatively small level of consumer satisfaction (8%) is moderated by product variations on consumer loyalty at PT Melia Sehat Sejahtera and product variety can play a direct role on consumer loyalty by (5%). This is due to the lack of variety of PT Melia Sehat Sejahtera's products.
Descarte de resíduos sólidos em aldeias indígenas de Roraima: alternativas e soluções para o saneamento rural
Authors: Bezerra Giovana Adélia Ausier Oliveira , Wankler Fábio  Luiz 
Published: March 2023

Este artigo discute os resultados das observações feitas durante uma visita in loco, em outubro de 2021 nas aldeias indígenas Parima e Makabey da Terra Indígena Yanomami, Roraima, com foco no manejo de resíduos sólidos. Identificou-se produtos com embalagens e substâncias não biodegradáveis e substâncias com alto potencial de contaminação, cujo descarte ocorre por queima ou dispersão errática no solo, o que favorece aparecimento de vetores e doenças e degradação ambiental. Concluiu-se é necessário um protocolo apropriado para o manejo aplicável nestes ambientes de difícil acesso, mas só será efetiva com a participação comunitária e melhoria percepção ambiental da comunidade através da Educação Ambiental.
Uso de los nuevos anticoagulantes orales en el síndrome antifosfolipidico: revisión bibliográfica
Authors: Iñiguez Mateo Nicolás Andrade , Espinoza Esteban Adrián Reibán , Ortiz Kevin Sebastian Criollo , Di Rosa Rebeca Rodríguez , Vivar María Angélica Córdova , Caraguay Sarahí Alejandra Vergara , Sanmartín Fausto Andrés Martínez , Lanzarin Ana Lara Braga 
Published: March 2023

Antecedentes. El síndrome antifosfolipídico es considerado a nivel mundial la trombofilia adquirida más abundante, con una prevalencia de 40 a 50 casos por cada 100.000 habitantes en general, con mayor predisposición en mujeres, con una relación 5:1 en contraste con pacientes varones. El tratamiento alternativo utilizado para esta patología en la última década se basa en la anticoagulación mediante anticoagulantes orales directos (ACOD), los cuales presenta una eficacia similar frente a los anticoagulantes tradicionales como las heparinas de bajo peso molecular (HBPM) o los antagonistas de la vitamina K (AVK), esta nueva terapéutica resulta muy atractiva, debido a que no se requiere monitorización, posee menos interacciones con otros fármacos o alimentos, se prescriben en una dosis fija con un efecto anticoagulante más predecible, un inicio de acción rápida, con lo que se pretende mejorar la calidad de vida de los pacientes. Metodología. El presente estudio es una revisión bibliográfica de tipo Scoping review con metodología PRISMA utilizando las bases de datos SCOPUS, PUBMED y WEB OF SCIENCE a través de descriptores bibliográficos con la utilización de palabras clave aplicando criterios de elegibilidad de inclusión y exclusión. Objetivo. Describir el uso de los nuevos anticoagulantes orales directos en el síndrome antifosfolipídico. Discusión y Resultados. Con un total de 16 artículos seleccionados se demostró que el uso de los nuevos anticoagulantes orales en la prevención secundaria es igual de efectiva a comparación de los anticoagulantes clásicos Conclusión. Los ACOD brindan características que pretenden brindar una mejorar calidad de vida de los pacientes sin embargo solo se recomienda en la proxifalis secundaria, luego de un primer evento tromboembólico y no se recomienda usar en trombosis arterial o pacientes doble o triple positivo.
Manejo da insônia na atenção primária: uma revisão sistemática
Authors: Campos Daniela Lima , Campos Poliana Lima , De Oliveira Tatiane Pires , Pereira Andreia Reis 
Published: March 2023

A insônia pode ser definida como uma condição subjetiva de sono inadequado, relacionada à dificuldade no seu início ou manutenção. É o distúrbio do sono mais comum, com taxas de prevalência variando de 5 a 48% e devido a sua importância requer diagnóstico preciso e tratamento eficiente. Atualmente os profissionais da atenção primária ainda dependem fortemente da higiene do sono e da farmacoterapia como opções terapêuticas principais. Assim, esta pesquisa teve como finalidade comparar os estudos já realizados sobre as medicações fornecidas pelo SUS que frequentemente são usadas no tratamento da insônia. Trata-se de uma revisão sistemática realizada no banco de dados da plataforma BVS usando as palavras-chave “Insomnia” and “Treatment” e o filtro “estudo clínico controlado”. Foram incluídos ensaios clínicos randomizados realizados com indivíduos acima de 18 anos sem comorbidades, que comparassem medicações usadas para insônia presentes na Relação Nacional de Medicamentos Essenciais com placebo e avaliados por medidas objetivas. Foram analisados oito estudos científicos relacionados a temática da pesquisa e que corresponderam satisfatoriamente aos critérios de inclusão. Através dessa revisão conclui-se que os benzodiazepínicos devem ser utilizados com cautela e a curto prazo devido ao perfil de efeitos colaterais. Anti-histamínicos ou antidepressivos não apresentaram evidências suficientes de resposta que indiquem seu uso para tratamento da insônia primária. Já a quetiapina demonstrou dados promissores que indicam que possivelmente seria uma boa opção para substituição dos hipnóticos tradicionais.
Examination of Digital Media Literacy Levels of University Students in Sports Education
Authors: Polatcan İsmail 
Published: March 2023

The purpose of this study is to examine the digital literacy levels of university students in sports education according to dependent and independent variables. The Digital Literacy Scale (DLS) was developed by Ng (2012) and adapted to Turkish by Hamutoglu et al. (2017). The Digital Literacy Scale consists of 4 sub-dimensions and 17 items. The sample of the study consisted of 517 university students and the data obtained were analyzed using the SPSS 25.0 software. The data collected from the participants were analyzed using an independent sample T-Test and One- Way ANOVA. The analyses conducted in the study revealed that the students had high levels of digital media literacy. A Pearson correlation analysis was completed to determine the level and direction of the relationship between dependent variables. The correlation analysis showed that the strongest, high-level relationship was between the “digital literacy scale” and its technical subdimension (r= 0.890; p<0.000). In conclusion, as the class and education level of students who do sports increase, the rise of digital literacy; It is thought that digital literacy between men and women will be parallel to the education of students in free and democratic conditions.
The Effects of Debating Technique on Science Prospective Teachers’ Willingness to Argue: An Example of Discussion as Regarding Renewable Energy Sources
Authors: Çolak Münevver Subaşı 
Published: March 2023

This study aimed to investigate the effect of debating activities on prospective science teachers’ willingness to argue. The sample group consisted of 27 students studying in the second year of Science Teaching. The Argumentation Willingness Scale and a structured interview form were used as research tools to collect data in the present study, conducted with an exploratory sequential mixed methods design lasting for five weeks for the purpose of examining the variation in prospective teachers’ willingness to argue. The Argumentation Willingness Scale was used to determine the prospective teachers’ level of willingness to argue before and after the implementation procedure. The resulting data were analysed with the paired samples t-test (a repeated measures t-test). Content analysis was also used to analyse the data obtained from the structured interview forms, which were administered after the procedure was completed in the qualitative dimension of the study.As a result of the quantitative data analysis, the debating activities were found to be efficacious in increasing the participants’ willingness to argue. The analysis of the qualitative data, on the other hand, revealed the prospective teachers’ views indicating that debating activities helped them acquirea number of skills such as research skills, discussion skills, and self-expression, and that they would use such activities especially while teaching socio-scientific issues in their professional life in the future.
Análise da qualidade da água de cisternas do povoado de Santa Cruz do Coqueiro, Mirangaba, Bahia
Authors: Rodrigues Vanessa Silva , Santos Juracir Silva 
Published: March 2023

O objetivo da pesquisa foi realizar análises físico-químicas e microbiológicas de amostras de água de cisternas do povoado de Santa Cruz do Coqueiro, localizado no município de Mirangaba, Bahia. Os parâmetros analisados foram: pH, turbidez, cor, coliforme totais e Escherichia Coli. As análises seguiram como referência os padrões estabelecidos pelo Standard Methods for the Examination of Water and Wastewater recomendado pelo Ministério da Saúde, através da Portaria GM/MS nº 888 de 2021. Em relação aos parâmetros físico-químicos as águas de cisterna estão de acordo o recomendado para consumo humano. No entanto, 100% das amostras das águas de cisterna analisadas apresentaram contaminação por coliformes totais, e 30% das amostras apresentaram a presença de E. coli, em desacordo com as normas da legislação para água potável, até a presente data. A contaminação microbiológica das águas de cisternas do povoado de Santa Cruz do Coqueiro por coliformes totais e E. coli pode estar associada ao uso e manejo inadequado dessa água. A manutenção dos cuidados e limpeza são importantes para manter as condições sanitárias evitando a contaminação da água e o comprometimento da saúde da população.
Abstract: The aim of this research it was to do physical-chemical and microbiological analyzes of water sample from cisterns from Santa Cruz do Coqueiro, Mirangaba city, Bahia, Brazil. The parameters analyzed were: pH, turbidity, color, total coliform and Escherichia coli. The analyzes took as reference the standards established by the Standard Methods for the Examination of Water and Wastewater recommended by the Brazilian Ministry of Health, through Ordinary law GM/MS nº 888/2021. According to the physico-chemical parameters the cistern water has been in agreement with the recommended for human use. Although, 100% from samples of cistern water analyzed presented contamination by total coliforms, and 30% of the samples revealed the presence of E. coli in disagreement with the laws of the current legislation for potable water. The microbiological contamination of the cisterns waters in Santa Cruz do Coqueiro by coliform and E. coli might be related to inappropriate use and management of this water. The maintenance of care and cleaning are important to keep the sanitary conditions, in order to avoid the water contamination as well as damages in the population health.
Keywords: Semiarid, Rain water, Indicator.
Cadernetas agroecológicas e seus impactos na economia de agricultura familiar do Território Piemonte da Diamantina: a experiência da COFASPI
Authors: Lino Carvalho Leonardo , Froes Lívia Tavares Mendes 
Published: March 2023

Este artigo analisa as rendas geradas e/ou geridas a partir de dados produzidos pela caderneta agroecológica, na área de atuação da COFASPI, no âmbito do projeto Pró-Semiárido. A caderneta agroecológica é um instrumento de mensuração criado pelo Centro de Tecnologias Alternativas da Zona da Mata – CTA/ZM para dar visibilidade ao trabalho das agricultoras familiares. Para este estudo, foram analisadas 2 cadernetas por município (Saúde, Mirangaba, Ourolândia e Umburanas), considerando as diferenças de cada município e o tipo de ação de comercialização exercida ou não por estas mulheres. Os resultados dessa análise indicaram uma contribuição expressiva, do ponto de vista da participação destas mulheres na renda de suas respectivas famílias. Assim, o estudo apresentado pode contribuir ativamente na melhoria dos levantamentos dos dados econômicos da agricultura familiar, bem como ampliando e melhorando a efetividade e o foco de políticas públicas.
ABSTRACT
This article analyzes the income generated and/or managed, based on data produced by the agroecological booklet, in the area where COFASPI operates, within the scope of the Pró-Semiárido project. The agroecological booklet is a measurement instrument created by the Centro de Tecnologias Al-ternativas da Zona da Mata – CTA/ZM to give visibility to the work of family farmers. For this study, 2 booklets were analyzed per municipality (Saúde, Mirangaba, Ourolândia and Umburanas), considering the differences in each municipality and the type of marketing activity carried out or not by these women. The results of this analysis indicated an expressive contribution, from the point of view of the participation of these women in the income of their respective families. Thus, the study presented can actively contribute to the improvement of surveys of economic data on family farm-ing, as well as expanding and improving the effectiveness and focus of public policies.

Keywords
Semiárido, Income, Gender, Agroecological booklet.
Study of contact resistance of α-Ga2O3 on m-plane sapphire substrate with respect to Sn concentration using the circular transfer length method
Authors: Yamafuji Yuto , Kikawa Junjiroh , Yamashita Syuhei , Shinohe Takashi , Araki Tsutomu 
Published: March 2023

Abstract
In this study, the Sn concentration dependence of the sheet and contact resistances of the m-plane α-Ga2O3 were analyzed and the corresponding current mechanism was determined. The measurements were performed using samples by systematically varying the Sn concentration from 1 × 1017 to 1 × 1019 cm–3. The circular transfer length method pattern was then fabricated, and the sheet and contact resistances were calculated. The Sn concentration dependence was determined for both the sheet and contact resistances. The thermionic field emission model was applied as a current mechanism for the contact resistance, and its results were compared with the values calculated using the Schottky barrier as a parameter. The effect of light illumination on the contact resistance was also analyzed.
” ألعاب اللغة “وأثرها في النقد والفكر المعاصر
Authors: مشكور مازن 
Published: March 2023

يسعى البحثُ إلى بيان أهمية مفهوم "ألعاب اللغة" عند فتجنشتاين، ثمّ يتقصّى تجلياتها المتنوعة في النقد والفكر اللاحقين له، ولا سيما الدَين الذي تُدين به نظريات ما بعد الحداثة، وما بعد البنيوية، فضلاً عن النظريات المدافعة عن الحداثة، وأخيراً لدى أصحاب التأويلية، هكذا حاول البحث تسليط الضوء على بعض الموضوعات التي تدخل من ضمن دائرة ألعاب اللغة والمفاهيم المُصاحبة لها، متمثلةً "بشكل الحياة"، والتشابه الأسري، وكل ما تشير إليه استعارة اللعبة في قصد فتجنشتاين، وهو ما تجلّى عند ليوتار عن طريق صياغته للنظرية المعرفية لما بعد الحداثة تتأسس على مفهوم ألعاب اللغة، فضلاً عن مفهومه الأهم "الخلاف"، وتأكيده للتعدّدية والاختلاف، فيما حاول هابرماس ترميم النظرية التحرُّرية للحداثة، باستثمار مفهوم فتجنشتاين في نظريته للفعل التواصلي ، وقد كان مفهوم اللعب محوراً لعمل الفيلسوف الألماني غادامير، في دراسته المعروفة "الحقيقة والمنهج"، إذ سلطنا الضوء على نقاط التقاطع بين الفيلسوفين .
الأساليب البديعيةة في شعر عدنان الصائغ ديوان (وَ....) أنموذجاً
Authors: بروين نور الدين , موسى ملاك 
Published: March 2023

عند العودة إلى التاريخ العربيّ, نجد أنّ أغلب الأقوال العربيّة تزخر بالفنون البلاغيّة , خاصّة منها الأساليب البديعيّة, الّتي تساعد في إظهار المعنى بأجمل صورة, وأكثر من هيئة, بصورة عفويّة جماليّة يسعى الشعراء دائماً إلى تحقيقها وإبرازها في أشعارهم, حتّى إنّ بعض الشعراء اتّخذوا البديع - كما في البديعيّات - منهج كتابيّاً في العصور المتأخّرة . وإنّ فضل الأساليب البديعيّة على الأدب , لم يختصر على جانب الجماليّ فقط _ كما في العصور الأولى _ ، بل أصبح يساهم في العصر الحديث, في حبكة النصّ، وزيادة العلاقة الترابطيّة بين دوالّ القصيدة، ومع مساهمته في إظهار المعنى بأكثر من صوره وحلّه, مع قدرته البالغة في إخفاء الغرض أو بيانه وتقويته وضعفه, مع الاستفادة من صفات الحروف, وتوظيفها بشكل بلاغيّ يدعم الهيئة الخارجيّة والدلاليّة لقصيدة, وبهذا أصبحت الأساليب البديعيّة ذات أثر جماليّ ودلاليّ وموسيقيّ على النصّ الأدبيّ. وأمّا الصائغ, فهو أحد شعراء العصر الحديث, الّذي برز في الثمانينات من القرن, في الدفاع عن الحقّ والحرّيّة والوطن, الّذي ذهب بيد الطاغية وشاكلته , ولذلك تعرّض إلى مضايقات عديدة, هاجر على أثرها إلى خارج العراق, امتاز أسلوبه الشعريّ بالسهولة والوضوح والتجديد في اللغة والصورة الأدبيّة , مع حضور الواقعيّة والحياة اليوميّة في أغلب دواوينه, مع طرقه لأغلب فنون الشعر العربيّ وخاصّة الحنين والشوق لأرض الوطن. يهدف المقال إلى إظهار أثر الأساليب البديعيّة في شعر عدنان الصائغ, بالاعتماد على المنهج الوصفيّ .
قصدية فهم الخطاب عند التلقي دراسة دلالية
Authors: كاظم ابراهيم , الشاعر حسن 
Published: March 2023

مفهوم الخطاب يُلقي الضوء على كيفية إنجاز الوظائف اللغوية التي يعبر بها منتج الخطاب عن مقاصده وتحقيق أهدافه من الخطاب؛ وهذا يتم عبر العلاقة المتبادلة بين النظام اللغوي وسياقات الاستعمال، مع العناية بالمستويات غير اللغوية بوصفها ذات سياقات اجتماعية خاصة .
وتستجلي دلالات الخطاب استعمالات المخاطِب؛ لضبط المعنى المراد من الخطاب؛ بغية الوصول إلى غرض المخاطِب.