bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network pharmacology and experiment indicated that medicinal food homologous components play important roles in insomnia
Authors: Xu Xiao , Liu Yang , Fu Xueqi , Li Guodong , Han Weiwei , Li Wannan 
Published: September 2023

AbstractInsomnia refers to a subjective experience where insufficient sleep duration and quality affect daytime social functioning. This study aims to screen bioactive components with medicinal food homologous (MFH), such as quercetin, beta‐sitosterol, kaempferol, stigmasterol, and capsaicin, which can treat insomnia and demonstrate that quercetin acts as a direct inhibitor of insomnia‐related glucosylceramidase and as an insulin receptor tyrosine phosphatase inhibitor in the upstream insulin signaling pathway, affecting insomnia targets in the downstream pathway for the treatment of insomnia, using network pharmacology and cell experiment approaches. The results showed that 703 components in 44 MFH were enriched in 139 metabolic pathways and acted on 210 potential targets of insomnia. The protein–protein interaction network is analyzed by cytoNCA, according to the topological analysis results, quercetin, beta‐sitosterol, kaempferol, stigmasterol, and capsaicin of betweenness ranked in the top 10. Quercetin and glucosylceramidase were shown to directly inhibit insomnia proteins through reverse molecular docking. Quercetin was used to culture and stimulate HepG2 cells to detect tyrosine phosphorylation of key cellular proteins in the insulin signaling pathway, concluding that quercetin inhibits the activity of tyrosine phosphatase in a dose‐dependent manner, activating the insulin signaling pathway, triggering a cascade reaction, and affecting the expression of insomnia targets in the downstream pathway. The molecular docking of tyrosine phosphatase and quercetin revealed that quercetin interacted with it near the catalytic site, thereby inhibiting its interaction with the substrate. Overall, this study facilitates the development of medicinal food homologous, which exerts good pharmacological effects in the treatment of insomnia.
Comparisons of pulsed ultrasound‐assisted and hot‐acid extraction methods for pectin extraction under dual acid mixtures from onion (Allium cepa L.) waste
Authors: Şen Emine , Göktürk Ersen , Hajiyev Vugar , Uğuzdoğan Erdal 
Published: September 2023

AbstractThe aim of this study is to compare the physicochemical properties and yields of pectins extracted from onion waste under hot acid (HAE) and pulsed ultrasound‐assisted extraction (PUAE) methods using different organic–inorganic acids, their mixtures, and pure water. The extraction temperature for experiments carried out under HAE was kept at 90°C for 90 min, whereas PUAE experiments were accomplished at RT in 15 min. In general, HAE gave better pectin yields compared with PUAE due to the significance of the increasing extraction temperature for the release of pectin from the plant matrix. While the maximum pectin yield from onion waste was 16.22% for HAE, the highest yield for PUAE was 9.83%. PUAE provides less time‐ and energy‐consuming extraction of pectin within 15 min and thus seems to be more economic compared with the HAE. According to the physicochemical properties (equivalent weight (EW), degree of esterification (DE), methoxyl (MeO), and galacturonic acid (Gal‐A) contents) of obtained pectins, extracted pectins were mostly high methoxy pectin. While the DE and MeO values of pectins extracted in organic acid conditions under HAE were higher, these values were found to be higher for pectins extracted in inorganic acids under PUAE. For acid mixtures, the DE and MeO values of pectins under HAE were mostly found to be lower than those under PUAE. Sequential PUAE and HAE methods for the extraction of pectin from onion waste were also found to be useful in terms of obtaining higher yields and better physicochemical properties. The highest pectin yield was 20.32% for the sequential PUAE and HAE methods. FT‐IR analyses of the extracted pectins by both HAE and PUAE methods showed similar vibration bands compared with those of commercial citrus pectin.
A database of detrital zircon geochronology ages of Cambrian to Paleogene deposits in South China
Authors: Xia Tianle , Li Kuizhou , Hu Lisha , Zhao Zilin , Huang Yu , Ma Qianli , Qi Liang 
Published: September 2023

AbstractComplications of detrital zircons databases provide a means for statistically analysing a variety of significant geological problems. In this work, we tried to collect a database about the South China Phanerozoic detrital zircon geochronology data. The data statistics of this paper rely on the OneSediment Working Group of The Deep‐time Digital Earth program (DDE). By November 2022, the database contains a total of 699 samples with 55,532 U–Pb ages and 3,770 effective Hf isotope data, from 130 papers. Abundant information including reference title, sample ID, locality, rock type, research institution, GPS coordinates, U–Pb ages, εHf(t) values, etc., have been involved in our database, and all data can be downloaded from DDE Data Publish & Repository website, https://repository.deep‐time.org/. Through the integrated data, we can improve the previous studies and avoid the waste of resources caused by a large number of repeated studies.
Pivot to prevent bowel cancer: Reflections on adapting an Aboriginal bowel cancer screening awareness program to a digital call to action—A commentary
Authors: Bonnefin Amy , Balafas Angela , Simone Lisa , Bedford Karen , Voukelatos Alexander , Hyde‐Page Alexander , Dalao Albert , Lyons Ricky , Coe Daniel , Wen Li Ming 
Published: September 2023

AbstractIssue AddressedThe Sydney Local Health District (SLHD) Health Promotion Unit was awarded a Cancer Institute NSW grant to raise awareness of bowel cancer and promote the National Bowel Cancer Screening Program (NBCSP) among Aboriginal communities in SLHD. The COVID‐19 pandemic thwarted initial plans for face‐to‐face workshops and plans pivoted to digital products and dissemination of messages on a range of communication platforms.DiscussionThe coronavirus (COVID‐19) pandemic provided staff with the freedom, flexibility, and ability to be creative in ways not possible prior to the pandemic and ultimately ended up with a superior product with a reach further than anticipated. A more comprehensive suite of digital resources addressing barriers to bowel cancer screening in the Aboriginal community was produced that is able to be used more broadly. These resources have reached a much larger population group through websites, social media, as well as TV and radio advertisements, and have the potential to be used and adapted in other local health districts and states across Australia.ConclusionAdapting an Aboriginal bowel cancer screening awareness program to a digital platform is a promising approach.So What?COVID‐19 provided an opportunity to create new long‐lasting partnerships and to be creative beyond the scope of the original grant. This in turn produced a product with a reach further than anticipated that can also be built on and sustained.
Acute colonic pseudo‐obstruction post‐cesarean section is not a benign entity: A case series and review of the literature
Authors: Reynolds Ian S. , McDermott Edward , Liddy Richard , Aird John J. , Flood Karen , McCormack Orla , Geoghegan Tony , Brannigan Ann E. 
Published: September 2023

AbstractAcute colonic pseudo‐obstruction (ACPO) is an infrequent occurrence after cesarean section. Anecdotal evidence suggests that the clinical course of ACPO in the obstetric setting is different to that seen in non‐pregnant adult patients with ACPO secondary to alternative causes, such as systemic illnesses, the use of certain medications, and after non‐abdominal surgery. The risk of progression to ischemia and perforation, as well as the need for emergency surgery, appears to be higher after cesarean section. Here we describe the clinical course of ACPO in four patients after cesarean section from our institution, followed by a review of the literature and a discussion of the important issues surrounding this condition in the postpartum time period. The findings from our cohort of patients and the reports from the medical literature support a hands‐on combined approach from a group of specialists including obstetricians, surgeons, radiologists, and enterostomal therapists. Immediate imaging followed by regular observation is mandatory for any patient being managed conservatively. Early use of endoscopic decompression should be considered for patients who are not resolving with a conservative approach. Clinical signs of peritonism or radiological signs of ischemia or perforation in patients with ACPO mandate immediate surgical intervention. Appropriate postoperative care is necessary to deal with the complex physiological and psychological consequences of emergency surgery and potential stoma formation so soon after cesarean section.
Evaluation on big data sharing model and key mechanism based on blockchain technology
Authors: Wu Wanqin , Liu Changrong , Yue Qingsheng , Bai Shenshen 
Published: September 2023

AbstractDue to the reliability and wide application of blockchain technology, it has attracted wide attention worldwide. Blockchain technology is widely used in finance, logistics, medicine, system management, and Bitcoin. This paper aimed to study how to analyze and study the sharing model and key mechanism of Big Data (BD) based on blockchain technology. This paper analyzed the impact of BD information resource sharing, then built an Ethernet‐based BD sharing system, and tested the performance of the system. This paper also analyzed the system response time, node mining speed test, transmission speed, security and stability of Inter Planetary File System (IPFS). IPFS and blockchain Ethernet are installed on 20 hosts in Ali Cloud and Tencent Cloud servers and laboratories, respectively. The consensus mining main grid consists of 4 Windows 7 systems. In the stability test data of relevant systems, when the number of users was 20 and 100, the system stability was 99.77% and 96.93% respectively. To sum up, the system designed in this paper has certain stability and security, and is worthy of further promotion and application.
Imaging peritoneal blood vessels through optical coherence tomography angiography for laparoscopic surgery
Authors: Lee Minsuk , Bang Hyeonjin , Lee Eungjang , Park Sungsoo , Yoo Hongki , Oh Wang‐yuhl , Lee Seungrag 
Published: September 2023

AbstractLaparoscopic surgery presents challenges in identifying blood vessels due to lack of tactile feedback. The image‐guided laparoscopic surgical tool (IGLaST) integrated with optical coherence tomography (OCT) has potential for in vivo blood vessel imaging; however, distinguishing vessels from surrounding tissue remains a challenge. In this study, we propose utilizing an inter‐A‐line intensity differentiation‐based OCT angiography (OCTA) to improve visualization of blood vessels. By evaluating a tissue phantom with varying flow speeds, we optimized the system's blood flow imaging capabilities in terms of minimum detectable flow and contrast‐to‐noise ratio. In vivo experiments on rat and porcine models, successfully visualized previously unidentified blood vessels and concealed blood flows beneath the 1 mm depth peritoneum. Qualitative comparison of various OCTA algorithms indicated that the intensity differentiation‐based algorithm performed best for our application. We believe that implementing IGLaST with OCTA can enhance surgical outcomes and reduce procedure time in laparoscopic surgeries.
Sustained neurotrophin‐3 delivery from hyaluronic acid hydrogels for neural tissue regeneration
Authors: Ramos Ferrer Pablo , Vardhan Sangamithra , Sakiyama‐Elbert Shelly 
Published: September 2023

AbstractThe goal of this work was to design a polymer‐based platform capable of localized, long‐term delivery of biologically active neurotropic factors using an affinity‐based approach. Here, we synthesized hyaluronic acid‐methylfuran (HA‐mF) hydrogels that provide sustained, affinity‐based release of neurotrophin‐3 (NT‐3), a growth factor that promotes axon growth for 28 days. A Diels‐Alder crosslinking reaction between HA‐mF and polyethylene glycol (PEG)‐dimaleimide occurs within 15 min under physiological conditions, resulting in hydrogels that can be polymerized in the presence of cells and growth factors. We also tuned the hydrogel's storage modulus to match that of native rat spinal cord tissue, providing a platform not only for localized drug delivery but also a suitable vehicle for cellular transplantation. The NT‐3 released from the HAmF hydrogels remains bioactive for at least 14 days, promoting axonal growth from primary sensory neurons as well as stem cell‐derived V2a interneurons and motoneurons in vitro. The hydrogels also supported cell growth allowing for 3‐dimensional axonal extensions within the scaffold matrix. Here we confirm the protective role of HA‐mF on matrix‐bound NT‐3 activity and show that these hydrogels are an excellent platform for growth factor delivery for neural applications.
Call for standardization in assessment and reporting of muscle and adipose change using computed tomography analysis in oncology: A scoping review
Authors: Klassen Pamela N. , Mazurak Vera C. , Thorlakson Jessica , Servais Stephane 
Published: September 2023

AbstractInvestigators are increasingly measuring skeletal muscle (SM) and adipose tissue (AT) change during cancer treatment to understand impact on patient outcomes. Recent meta‐analyses have reported high heterogeneity in this literature, representing uncertainty in the resulting estimates. Using the setting of palliative‐intent chemotherapy as an exemplar, we aimed to systematically summarize the sources of variability among studies evaluating SM and AT change during cancer treatment and propose standards for future studies to enable reliable meta‐analysis. Studies that measured computed tomography‐defined SM and/or AT change in adult patients during palliative‐intent chemotherapy for solid tumours were included, with no date or geographical limiters. Of 2496 publications screened by abstract/title, 83 were reviewed in full text and 38 included for extraction, representing 34 unique cohorts across 8 tumour sites. The timing of baseline measurement was frequently defined as prior to treatment, while endpoint timing ranged from 6 weeks after treatment start to time of progression. Fewer than 50% specified the actual time interval between measurements. Measurement error was infrequently discussed (8/34). A single metric (cm2/m2, cm2 or %) was used to describe SM change in 18/34 cohorts, while multiple metrics were presented for 10/34 and no descriptive metrics for 6/34. AT change metrics and sex‐specific reporting were available for 10/34 cohorts. Associations between SM loss and overall survival were evaluated in 24 publications, with classification of SM loss ranging from any loss to >14% loss over variable time intervals. Age and sex were the most common covariates, with disease response in 50% of models. Despite a wealth of data and effort, heterogeneity in study design, reporting and statistical analysis hinders evidence synthesis regarding the severity and outcomes of SM and AT change during cancer treatment. Proposed standards for study design include selection of homogenous cohorts, clear definition of baseline/endpoint timing and attention to measurement error. Standard reporting should include baseline SM and AT by sex, actual scan interval, SM and AT change using multiple metrics and visualization of the range of change observed. Reporting by sex would advance understanding of sexual dimorphism in SM and AT change. Evaluating the impact of tissue change on outcomes requires adjustment for relevant covariates and concurrent disease response. Adoption of these standards by researchers and publishers would alter the current paradigm to enable meta‐analysis of future studies and move the field towards meaningful application of SM and AT change to clinical care.
Overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma
Authors: Toner Keri , Allen Carl E. , Jain Shweta , Kahl Brad , Leonard John , Wasserstrom Heather , Friedberg Jonathan W. , Seibel Nita L. , Kelly Kara 
Published: September 2023

AbstractLymphoma is one of the most common cancers in adolescents and young adults, but historically, this population has had lower clinical trial enrollment and improvements in overall survival as compared to other age populations. There are multiple challenges that are unique to this population that have affected drug development and clinical trial enrollment. Our panel of experts have identified barriers, and in this review, we discuss current methods to address these barriers as well as potential solutions moving forward.
Butterfly abundance is higher in areas treated for fire ants
Authors: Geest Emily A. , Berman David D. , Baum Kristen A. 
Published: September 2023

AbstractRed imported fire ants (Solenopsis invicta; fire ants) are an invasive species that prey on arthropods in the southern United States. Researchers examined using fire ants to control agricultural Lepidoptera pests, but minimal research has investigated the effects of fire ants on the broader butterfly community. Three ranches in Texas, USA, with known fire ant occurrence underwent treatment to remove fire ants, creating a treated section and an untreated section for each ranch. We sampled sites using colored pan traps 3 times per sampling period during 2018 and 2019. Over 2 years, we collected 1,262 butterflies across 28 species in pan traps. Average butterfly abundance was higher in treated sites than untreated sites. The majority of species collected were in the family Hesperiidae, followed by the Pieridae family. We found Hesperiidae species more often in blue pan traps and Pieridae species more often in yellow pan traps. Butterfly species that overwinter as immature stages were more abundant in treated sites than in untreated sites, which suggests there could be a connection between fire ant presence and mortality of overwintering immature stages. Our results suggest that fire ants may negatively affect butterfly communities and differentially affect certain species. Additional research is needed to understand the effects of fire ants on butterflies and the overall pollinator community, and the effectiveness of pan traps for surveying Lepidoptera.
Age‐Related Histologic and Biochemical Changes in Auricular and Nasal Cartilages
Authors: Kim Sul Gi , Menapace Deanna C. , Mims Mark M. , Shockley William W. , Clark J. Madison 
Published: September 2023

ObjectiveAnalyze age‐related changes in histologic features and biochemical properties of human auricular cartilage and two subsites of nasal cartilages (quadrangular cartilage and dorsal septal articulation with upper lateral cartilages).Study DesignProspective cross‐sectional study of nasal and auricular cartilages from seventy‐three (73) live donors.MethodsAuricular cartilage (AC), quadrangular cartilage (QC), and dorsal septal cartilage articulation (DSA) with the upper lateral cartilage (ULCs) were collected intraoperatively. Histochemical staining was used: Safranin O for glycosaminoglycans (GAGs), Verhoeff's for elastin, and Masson's trichrome for collagen. ImageJ2 software was used to calculate cell count and percent stained for each cartilage type. R studio “ggplot” package was used to visualize age versus cell count or percent stained.ResultsParticipant ages ranged from 20 to 77 years, average 46.5 years. There was a significant decline in GAGs with age for the DSA subsite, (n = 64, p < 0.001). Significant increase in collagen content with age was observed for DSA subsite (n = 66, p < 0.001) and the QC subsite (n = 64, p < 0.05). There was a statistically insignificant decline in elastin with age (n = 41, p = 0.309) for AC. Cell count declined with age at all cartilage subsites.ConclusionOur findings confirm that there were age‐related decreases in cartilage glycosaminoglycan content, and chondrocyte cell count in both auricular and nasal cartilages. We have also confirmed that collagen content increases with age for both auricular and nasal cartilage. The histologic findings while not statistically significant in all comparisons, provides additional evidence that there is some loss of structural integrity and flexibility in nasal and auricular cartilage with aging.Level of EvidenceNA Laryngoscope, 134:1220–1226, 2024
Prospective >12 Months Outcomes After Vocal Fold Injection Medialization With Silk Microparticle‐Hyaluronic Acid Material
Authors: Gao William Z. , Paoletti Marcus F. , Bensoussan Yael , Bhatt Neel K. , van der Woerd Benjamin , Shuman Elizabeth A. , Grant Nazaneen , O'Dell Karla , Johns Michael M. 
Published: September 2023

ObjectiveVocal fold injection medialization (VFIM) is widely used as an initial treatment for unilateral vocal fold paralysis (UVFP). Current practices employ materials that share the limitation of temporary clinical effect from variable resorption rates. A novel silk protein microparticle‐hyaluronic acid‐based material (silk‐HA) has demonstrated cellular infiltration and tissue deposition that may portend a durable medialization effect. We report on ≥12 months outcomes after VFIM with silk‐HA.MethodsProspective open‐label study of patients with UVFP that elected treatment with VFIM with silk‐HA. Blinded experts rated laryngeal stroboscopic exams.ResultsSeventeen patients with UVFP underwent VFIM with silk‐HA. Twelve of the 17 patients have ≥12 months follow‐up. Seven patients demonstrated durable treatment benefit ≥12 months after injection with median improvement of 19 (p = 0.0156) in VHI‐10. There was no significant change in VHI‐10 between 1 and 12 months for these patients. Blinded ratings indicated that 5/7 patients with sustained improvements in VHI‐10 exhibited complete or touch glottal closure at 12 months. Two of the seven patients exhibited a small (<1 mm) glottal gap at 12 months. Seven patients experienced initial benefit with later regression 3–4 months after injection.ConclusionVFIM with silk‐HA can offer durable improvement in voice‐related outcomes for UVFP past 12 months. A subset of patients treated with silk‐HA experienced early loss of effect around 3–4 months postinjection. Clinical factors predictive of sustained treatment response to silk‐HA injection require further exploration.Level of Evidence3 Laryngoscope, 134:3679–3685, 2024