bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is there a correlation between sensory impairments and social isolation in middle-aged and older Chinese population? Cross-sectional and longitudinal evidence from a nationally representative survey
Authors: Liu Ye , Sun Qinglei , Abuduxukuer KaiweiSa , Hou Yanan , Wei Jin , Liu Haiyun , Luo Jianfeng , Gao Guangfeng , Zhou Yifan 
Published: March 2023

PurposeThe aim of this study is to investigate the cross-sectional and longitudinal associations between sensory impairments (SIs) including single vision impairment (SVI), single hearing impairment (SHI), and dual sensory impairments (DSI) with social isolation in the middle-aged and older Chinese population.MethodsData were obtained from the China Health and Retirement Longitudinal Survey (CHARLS). In total, 11,674 Chinese older adults aged over 45 were included at baseline 2011, and 6,859 participants who accomplished all four interviews from 2011 to 2018 were adapted for longitudinal analyses. Sensory status and social isolation measurements including social disconnectedness and self-perceived loneliness were collected. Assessment of social disconnectedness included the number of types of social activities in which they participated and the frequency of such participation. Loneliness referred to the subjective perception of loneliness. Other covariates included socio-demographic characteristics, medical conditions, and lifestyle-related factors. The impacts of baseline sensory status on social disconnectedness and loneliness were assessed using univariate and multivariate generalized linear models. A generalized linear model with generalized estimation equations (GEE) was used to assess the association between time-varying sensory statuses with social disconnectedness or loneliness over 8 years after being adjusted with multi-confounding factors.ResultsParticipants with SIs had significantly higher levels of social disconnectedness and self-perceived loneliness, compared to those who were free of SI. All kinds of SIs were significantly associated with loneliness according to both cross-sectional and longitudinal data. The correlations between DSI and social disconnectedness or loneliness at baseline and over 8 years were also noticed. SHI was found to be significantly associated with both frequency and types of social activities according to cross-sectional data and with the frequency of social activity participation in longitudinal analysis. SVI was only associated with the types of social activities at baseline (all p-values &lt; 0.05).ConclusionSensory impairments, especially dual sensory impairments, have explicitly detrimental effects on social isolation among the older Chinese population. Over time, single hearing impairment specifically jeopardizes their frequency rather than types of social activities participation.
Determinants of non-completion of sleep apnea testing during pregnancy
Authors: Antony Kathleen M. , Rice Alexandra Lauren , Bajaj Sakshi , Wiedmer Abigail M. , Jacobson Natalie , Nick Julia , Eichmann Allison , Stanic Aleksandar K. , Bazalakova Mihaela H. 
Published: March 2023

Study objectivesCompletion of testing during pregnancy for those who screen positive for obstructive sleep apnea (OSA) is imperative for the diagnosis and treatment of OSA, as the latter may reduce the risk of developing hypertensive disorders of pregnancy. To identify potential barriers, we assessed predictors of non-completion of sleep apnea testing by people identified to be at high risk of OSA by screening during pregnancy. We hypothesized that non-completion of sleep apnea testing would be predicted by insurance status and obstetric factors, such as gestational age at time of testing.MethodsWe performed a retrospective analysis of the first 500 people in our sleep pregnancy database which includes both pregnant and preconception patients who screened positive for OSA; those screened preconception were excluded. Multivariable Poisson regression was used to determine which factors were independently associated with non-completion.ResultsOf 445 referred, 214 (48.1%) completed sleep apnea testing. Factors associated with non-completion of testing on univariate analysis included referral in the third trimester, higher parity, one or more living children, history of preterm birth, history of preeclampsia, type 2 diabetes mellitus, non-partnered status, race, and payor. Symptoms of loud snoring or witnessed apneas were associated with increased incidence of sleep apnea testing completion. Multivariable Poisson regression demonstrated that having public insurance predicted non-completion of sleep apnea testing during pregnancy.ConclusionIn this small study, public insurance was an independent predictor of non-completion of sleep apnea testing during pregnancy. These findings aid efforts to improve patient completion of sleep apnea testing during pregnancy.
Exploring the role of virtual reality in military decision training
Authors: Harris D. J. , Arthur T. , Kearse J. , Olonilua M. , Hassan E. K. , De Burgh T. C. , Wilson M. R. , Vine S. J. 
Published: March 2023

Introduction: Simulation methods, including physical synthetic environments, already play a substantial role in human skills training in many industries. One example is their application to developing situational awareness and judgemental skills in defence and security personnel. The rapid development of virtual reality technologies has provided a new opportunity for performing this type of training, but before VR can be adopted as part of mandatory training it should be subjected to rigorous tests of its suitability and effectiveness.Methods: In this work, we adopted established methods for testing the fidelity and validity of simulated environments to compare three different methods of training use-of-force decision making. Thirty-nine dismounted close combat troops from the UK’s Royal Air Force completed shoot/don’t-shoot judgemental tasks in: i) live fire; ii) virtual reality; and iii) 2D video simulation conditions. A range of shooting accuracy and decision-making metrics were recorded from all three environments.Results: The results showed that 2D video simulation posed little decision-making challenge during training. Decision-making performance across live fire and virtual reality simulations was comparable but the two may offer slightly different, and perhaps complementary, methods of training judgemental skills.Discussion: Different types of simulation should, therefore, be selected carefully to address the exact training need.
Optimal strategy for delirium detection in older patients admitted to intensive care unit after non-cardiac surgery
Authors: Wang Kun , Su Xian , Ma Jia-Hui , Wang Dong-Xin 
Published: March 2023

BackgroundDelirium detection is challenging due to the fluctuating nature and frequent hypoactive presentation. This study aimed to determine an optimal strategy that detects delirium with higher sensitivity but lower effort in older patients admitted to the intensive care unit (ICU) after surgery.MethodsThis was a secondary analysis of the database from a randomized trial. Seven hundred older patients (aged ≥65 years) who were admitted to the ICU after elective noncardiac surgery were enrolled. Delirium was assessed with the Confusion Assessment Method for the ICU (CAM-ICU) twice daily during the first 7 days postoperatively. The sensitivity of different strategies in detecting delirium were analyzed and compared.ResultsOf all enrolled patients, 111 (15.9%; 95% CI: 13.3% to 18.8%) developed at least one episode of delirium during the first 7 postoperative days. Among patients who developed delirium, 60.4% (67/111) had their first delirium onset on postoperative day 1, 84.7% (94/111) by the end of day 2, 91.9% (102/111) by the end of day 3, and 99.1% (110/111) by the end of day 4. Compared with delirium assessment twice daily for 7 days, twice-daily measurements for 5 days detected 100% of delirium patients with 71% efforts; twice-daily measurements for 4 days detected 99% (95% CI: 94% to 100%) of delirium patients with 57% efforts; twice-daily assessment for 3 days detected 92% (95% CI: 85% to 96%) of delirium patients with only 43% efforts.ConclusionsFor older patients admitted to the ICU after elective noncardiac surgery, it is reasonable to detect delirium with the CAM-ICU twice daily for no more than 5 days, and if the personnel and funds are insufficient, 4 days could be sufficient.
Comparison of the respiratory bacterial microbiome in cats with feline asthma and chronic bronchitis
Authors: Werner Melanie , Weeger Jasmin , Hörner-Schmid Lina , Weber Karin , Palić Jelena , Shih Jonathan , Suchodolski Jan S. , Pilla Rachel , Schulz Bianka 
Published: March 2023

ObjectivesWhile feline chronic bronchitis (CB) is known as neutrophilic bronchial inflammation (NI), feline asthma (FA) is defined as an eosinophilic airway inflammation (EI). Feline chronic bronchial disease refers to both syndromes, with similar clinical presentations and applied treatment strategies. Recent studies described alterations of the microbiota composition in cats with FA, but little is known about the comparison of the lung microbiota between different types of feline bronchial disease. The study aimed to describe the bacterial microbiota of the lower respiratory tracts of cats with FA and CB and to identify potential differences.MethodsTwenty-two client-owned cats with FA (n= 15) or CB (n= 7) confirmedviabronchoalveolar-lavage (BALF)-cytology were included. Next-generation sequencing analysis of 16S rRNA genes was performed on bacterial DNA derived from BALF samples. QIIME was used to compare microbial composition and diversity between groups.ResultsEvenness and alpha-diversity-indices did not significantly differ between cats with FA and CB (Shannonp= 0.084, Chao 1p= 0.698, observed ASVsp= 0.944). Based on a PERMANOVA analysis, no significant differences were observed in microbial composition between animals of both groups (Bray-Curtis metric,R-value 0.086,p= 0.785; unweighted UniFrac metric,R-value −0.089,p= 0.799; weighted Unifrac metric,R-value −0.072,p= 0.823). Regarding taxonomic composition, significant differences were detected forActinobacteriaon the phylum level (p= 0.026),Mycoplasmaspp. (p= 0.048), andAcinetobacteria(p= 0.049) on the genus level between cats with FA and CB, with generally strong interindividual differences seen. There was a significant difference in the duration of clinical signs before diagnosis in animals dominated byBacteriodetes(median 12 months, range 2–58 months) compared to animals dominated byProteobacteria(median 1 month, range 1 day to 18 months;p= 0.003).Conclusions and relevanceLung microbiota composition is very similar in cat populations with spontaneous FA and CB besides small differences in some bacterial groups. However, with disease progression, the lung microbiome of cats with both diseases appears to shift away from dominantlyProteobacteriato a pattern more dominated byBacteriodetes. A substantial proportion of cats tested positive forMycoplasmaspp.viasequencing, while none of them tested positive using classical PCR.
Systematic Review and Guidelines for Management of Scrotal Inguinal Hernias
Authors: Tran Hanh Minh , MacQueen Ian , Chen David , Simons Maarten 
Published: March 2023

Introduction: Of the more than 20 million patients undergoing groin hernia repair annually worldwide, 6% are scrotal hernias in high resource countries rising to 67% in low resource countries which represents a heavy disease burden on relatively young men during their most productive period of life. There are many open questions concerning management of scrotal hernia. These guidelines aim to improve the care for scrotal hernia patients by reducing recurrence rates, chronic pain and infection.Methods: After developing 19 key questions a systematic literature review was performed till 31 March 2021 for all relevant publications with search terms related to Scrotal Hernia. The articles were scored by all co-authors according to Oxford, SIGN and Grade methodologies. Statements and recommendations were formulated. Online Consensus meetings with 25 HerniaSurge members were organised with voting and grading Recommendations as “strong” (recommendations) or “weak” (suggestions) and by consensus, in some cases upgraded.Results: Only 23 articles (two level 2 registry and 21 level 3–5) were selected. It is proposed to define scrotal hernia as an inguinal hernia which has descended into and causes any scrotal distortion. A new classification for scrotal hernias was proposed based on hernia size, SI for upper third thigh, SII for middle thigh and SIII for lower third thigh or below. Irreducibility is denoted with IR. Despite weak evidence antibiotic prophylaxis is recommended. Urinary catheterization is recommended (upgraded) in complex cases (S2-3) due to prolonged operative time. Scrotal hernia repairs have higher associated morbidity and mortality compared to non-complex groin hernia repairs irrespective of surgical experience. Open anterior (mesh) approach is commonest technique and suture techniques in low resource countries. For minimally invasive approaches, TAPP resulted in less conversion to open approach compared to TEP.Conclusion: Although the evidence is scarce and often low quality scrotal hernia management guidelines aim to lead to better surgical outcomes irrespective of where patients live. This necessarily means a more tailored approach based on available resources and appropriate skills. The guidelines provide an impetus for future research where adoption of proposed classification will enable more meaningful comparison of different techniques for different hernia sizes.
Plumbagin Exhibits Genotoxicity and Induces G2/M Cell Cycle Arrest via ROS-Mediated Oxidative Stress and Activation of ATM-p53 Signaling Pathway in Hepatocellular Cells
Authors: Liu Huan , Zhang Wenchao , Jin Lijie , Liu Shasha , Liang Liying , Wei Yanfei 
Published: March 2023

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone, PLB), a naturally occurring naphthoquinone mainly isolated from the plant Plumbago zeylanica L., has been proven to possess anticancer activities towards multiple types of cancer. Although there has been an increasing amount of research regarding its anticancer effects, the association between oxidative stress, genotoxicity and the cell cycle arrest induced by PLB still remains unclear. Therefore, it is important to investigate their potential connections and the involvement of DNA damage and the ataxia telangiectasia mutated protein (ATM)-p53 signaling pathway in PLB’s anticancer mechanism. The present study showed that PLB exposure significantly reduced HCC cell viability and colony formation. In addition, PLB-induced G2/M cell cycle arrest, oxidative stress, and DNA damage was detected, which could be almost blocked by NAC pretreatment. PLB could trigger a DNA damage response by activating cell cycle checkpoints such as ATM, checkpoint kinase 1 (Chk1), checkpoint kinase 2 (Chk2) and p53. Meanwhile, the key modulator of the G2/M transition factor, Cell Division Cycle 25C (cdc25C), was significantly downregulated in an ROS-dependent manner. Furthermore, pretreatment with ATM and p53 inhibitors (KU55933 and Pifithrin-α) could reduce the occurrence of G2/M cell cycle arrest by inhibiting the activation of the ATM-p53 pathway. Taken together, these results indicate that ROS-mediated oxidative stress plays a key role in PLB-induced G2/M cell cycle arrest mediated by the ATM-p53 pathway.
Incidence, Mortality, and Survival Trends in Cancer of the Gallbladder and Extrahepatic Bile Ducts in Lithuania
Authors: Dulskas Audrius , Cerkauskaite Dovile , Patasius Ausvydas , Smailyte Giedre 
Published: March 2023

Background and Objectives: Gallbladder cancer is a rare type of cancer, with aggressive clinical behavior. Limited treatment options provide poor survival prognosis. We aimed to investigate the incidence, mortality trends, and survival of gallbladder and extrahepatic bile duct cancer in Lithuania between 1998 and 2017. Materials and Methods: The study was based on the Lithuanian Cancer Registry database. The study included all cases of cancer of the gallbladder and extrahepatic bile ducts reported to the Registry in the period 1998–2017. Age-specific and age-standardized incidence rates were calculated. In addition, 95% confidence intervals for APC (Annual Percent Change) were calculated. Changes were considered statistically significant if p was <0.05. Relative survival estimates were calculated using period analysis according to the Ederer II method. Results: Age-standardized rates for gallbladder cancer and extrahepatic bile duct cancer among females decreased from 3.91 to 1.93 cases per 100.000 individuals between 1998 and 2017, and from 2.32 to 1.59 cases per 100.000 individuals between 1998 and 2017 among males. The highest incidence rates were found in the 85+ group with 27.5/100,000 individuals in females and 26.8/100,000 individuals in males. The 1-year as well as 5-year relative survival rates of both genders were 34.29% (95% CI 32.12–36.48) and 16.29% (95% CI 14.40–18.27), respectively. Conclusions: Incidence and mortality from gallbladder and extrahepatic bile duct cancer decreased in both sexes in Lithuania. Incidence and mortality rates were higher in females than in males. Relative 1-year and 5-year survival rates showed a steady increase during the study period among males and females.
Biblioteca agiografica italiana. Du projet à la publication
Authors: Dalarun Jacques , Leonardi Lino 
Published: March 2023

Cet article offre la version française de l’Introduzione de la Biblioteca agiografica italiana, une entreprise promue par la Fondazione Ezio Franceschini et l’École française de Rome, qui débouche aujourd’hui sur la publication d’un livre en deux volumes et d’un CD-Rom. S’inspirant du modèle de la Bibliotheca hagiographica latina,
la BAI répertorie 1776 textes en italien antérieurs à 1500, dédiés à 548 saints. Fondée sur une large enquête bibliographique, la BAI s’est aussi enrichie du dépouillement des catalogues de manuscrits, voire de l’examen direct de quelques manuscrits ; ce qui permet d’ajouter de nouveaux témoins pour des textes déjà connus, de mettre au jour de nouveaux textes, d’inclure des saints qui n’étaient pas attestés par la seule bibliographie. La structure du dossier d’un saint dans la BAI est ensuite présentée en détail, ainsi que les moyens d’investigation qu’offrent les index dans le livre imprimé et le programme de consultation dans le CD-Rom.
Autour de l’édition du Registrum Petri Diaconi. Problèmes de documentation cassinésienne : chartes, rouleaux, registre
Authors: Chastang Pierre , Feller Laurent , Martin Jean-Marie 
Published: March 2023

Le Registrum Petri Diaconi, cartulaire général du Mont-Cassin compilé entre 1131 et 1133, dont on prépare l’édition, a déjà été mis en rapports avec les
Chronica monasterii Casinensis. Il est, en outre, le seul des grands cartulaires compilés à cette époque dans l’Italie centro-méridionale que l’on peut confronter aux archives de l’abbaye, dont l’essentiel a été préservé. Environ 160 des 716 documents qu’il contient sont encore conservés en originaux, d’autres sous la forme de copies anciennes, dont certaines se trouvent dans des registres et autres manuscrits de l’abbaye, qui possède également d’importantes compilations du XVIIIe siècle. On en donne la liste. La comparaison permet d’évaluer précisément le travail des compilateurs. On peut encore le confronter aux regestes contenus dans deux rotuli conservés à l’Archivio, qui lui sont pratiquement contemporains. Le rotulus V2, sans doute compilé sous la direction de Pierre Diacre, contient les regestes de 320 documents. Il a la même organisation générale que le cartulaire, dans lequel sont copiés, pratiquement dans le même ordre, les documents qu’il enregistre. Il est donc l’un des modèles suivis pour établir le cartulaire. En outre, son analyse permet de diviser ce dernier en sections, chacune sans doute confiée à un groupe de scribes ; certaines suivent V2, d’autres ont dû prendre d’autres modèles. On donne une édition du rotulus V 2 et un tableau de correspondance entre le contenu du rouleau et celui du Registrum Petri Diaconi. registres et autres manuscrits de l’abbaye, qui possède également d’importantes compilations du XVIIIe siècle. On en donne la liste. La comparaison permet d’évaluer précisément le travail des compilateurs. On peut encore le confronter aux regestes contenus dans deux rotuli conservés à l’Archivio, qui lui sont pratiquement contemporains. Le rotulus V2, sans doute compilé sous la direction de Pierre Diacre, contient les regestes de 320 documents. Il a la même organisation générale que le cartulaire, dans lequel sont copiés, pratiquement dans le même ordre, les documents qu’il enregistre. Il est donc l’un des modèles suivis pour établir le cartulaire. En outre, son analyse permet de diviser ce dernier en sections, chacune sans doute confiée à un groupe de scribes ; certaines suivent V2, d’autres ont dû prendre d’autres modèles. On donne une édition du rotulus V 2 et un tableau de correspondance entre le contenu du rouleau et celui du Registrum Petri Diaconi.
TRATAMIENTO QUIRÚRGICO DEL LEIOMIOSARCOMA DE VENA CAVA INFERIOR.
Authors: Aparicio-López Daniel , Ruiz Quijano Pablo , Recio Cabrera Adoración , Ligorred Padilla Luis A. 
Published: March 2023

Introducción: La baja incidencia del leiomiosarcoma de la vena cava inferior dificulta tanto la estandarización del diagnóstico como el tratamiento.Objetivo: Presentar el manejo realizado en nuestro centro de un paciente que desarrolló un leiomiosarcoma de vena cava inferior, una patología de baja incidencia y que las posibilidades de realizar un rescate quirúrgico son muy bajas.Resultados: Se presenta el caso de un paciente de 54 años con una tumoración sólida en porción infrarrenal y yuxtarrenal de vena cava inferior de 71x76x117 mm compatible con leiomiosarcoma de vena cava, con infiltración de uréter derecho que ocasiona uropatía obstructiva derecha grado I-II sin alteración de la función renal; que fue resecada y reconstruida mediante prótesis sin complicaciones.Discusión: Se discute la fisiopatología, el diagnóstico y manejo en relación con el caso presentado.Conclusión: la baja incidencia de estos tumores dificulta tanto la estandarización del diagnóstico como del tratamiento, aunque la cirugía sigue siendo el tratamiento de elección.