bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmentally Induced Sperm RNAs Transmit Cancer Susceptibility to Offspring in a Mouse Model
Authors: Cruz Raquel da , Dominguez Odalys , Chen Elaine , Gonsiewski Alexandra , Nasir Apsra , Cruz M.Idalia , Zou Xiaojun , Galli Susana , Makambi Kepher , McCoy Matthew , Schmidt Marcel , Jin Lu , Peran Ivana , de Assis Sonia 
Published: February 2023

Abstract
DNA sequence accounts for the majority of disease heritability, including cancer. Yet, not all familial cancer cases can be explained by genetic factors. It is becoming clear that environmentally induced epigenetic inheritance occurs and that the progeny’s traits can be shaped by parental environmental experiences. In humans, epidemiological studies have implicated environmental toxicants, such as the pesticide DDT, in intergenerational cancer development, including breast and childhood tumors. Here, we show that the female progeny of males exposed to DDT in the pre-conception period have higher susceptibility to developing aggressive tumors in mouse models of breast cancer. Sperm of DDT-exposed males exhibited distinct patterns of small non-coding RNAs, with an increase in miRNAs and a specific surge in miRNA-10b levels. Remarkably, embryonic injection of the entire sperm RNA load of DDT-exposed males, or synthetic miRNA-10b, recapitulated the tumor phenotypes observed in DDT offspring. Mechanistically, miR-10b injection altered the transcriptional profile in early embryos with enrichment of genes associated with cell differentiation, tissue and immune system development. In adult DDT-derived progeny, transcriptional and protein analysis of mammary tumors revealed alterations in stromal and in immune system compartments. Our findings reveal a causal role for sperm RNAs in environmentally induced inheritance of cancer predisposition and, if confirmed in humans, this could help partially explain some of the “missing heritability” of breast, and other, malignancies.
Percutaneous endoscopic lumbar discectomy for calcified lumbar disc herniation: A retrospective study
Authors: Feng Xinjian , Yi Shenghui , Chen Huiming 
Published: February 2023

Abstract
Background: Percutaneous endoscopic discectomy (PELD), which includes percutaneous endoscopic interlaminar discectomy (PEID) and percutaneous endoscopic transforaminal discectomy (PETD), is a minimally invasive procedure for the treatment of lumbar disc herniation (LDH) . However, studies on PELD for calcified lumbar disc herniation (CLDH) have rarely been recorded. The purpose of this study was to evaluate the PELD's clinical effectiveness for CLDH.
Methods: A retrospective analysis of 45 CLDH patients who got PELD in our department from June 2018 to April 2021 was conducted. Patients were divided into two groups: the PEID group (n = 24) and the PETD group (n = 21) based on the surgical methods. The demographic characteristics and surgical results of the two groups were compared. Utilizing the visual analog scale (VAS) for leg pain, the Oswestry disability index (ODI), and the modified MacNab criteria, clinical results were examined.
Results: PEID or PETD procedures were effective for every patient. There were no discernible changes in the demographics, postoperative hospital stay, operating time, intraoperative blood loss, or complication rate between the PEID and PETD group (p>0.05). When compared to the preoperative period following PELD, the leg pain VAS ratings and ODI scores were considerably lower at each follow-up time (p> 0.05), respectively. After surgery, however, there were no appreciable variations in the VAS and ODI ratings between the PEID and PETD groups (p>0.05). The PEID group outperformed the PETD group in terms of fluoroscopy times, although the modified MacNab criteria were equal in both groups (p>0.05).
Conclusions: While PEID has a shorter fluoroscopy duration, both PEID and PETD are minimally invasive treatments for CLDH.
A national survey of Supervised Toothbrushing Programmes in England
Authors: Gray-Burrows Kara , Day Peter , Elyousfi Sarab , Lloyd Ellen , Hudson Kristian , Marshman Zoe 
Published: February 2023

Abstract
Introduction: Supervised toothbrushing programmes (STP) are a cost-effective public health intervention reducing tooth decay and health inequalities in children. However, the uptake of STP in England is unknown. This study aimed to establish the current provision of STP across England and summarise the barriers and facilitators to their implementation.
Methods: An online survey was sent to dental public health consultants, local authority (LA) oral health leads, and public health practitioners across England. Quantitative data was analysed using descriptive statistics. Barriers and facilitators were analysed using the Consolidated Framework for Implementation Research (CFIR).
Results: Information was received for 141 LAs across England. Approximately half implemented a STP (N=68/141). Most STPs were commissioned by LAs (N=44/68) and adopted a targeted approach (N=54/68). Barriers to implementation were: (1) Funding; (2) Communication & Engagement; (3) Relative priority; (4) Logistics; (5) Capacity. Facilitators were: (1) Integrated & mandated public health approach; (2) Collaboration & Ongoing Support; (3) Clarity; (4) Flexibility; (5) Available resources; (6) Ownership & Empowerment.
Conclusion: The current provision of STPs is varied, and although there are challenges to their implementation, there are also areas of good practice where these challenges have been overcome.
Endothelial Injury Syndromes after Allogeneic Hematopoietic Stem Cell Transplantation: The Role of Functional Autoantibodies against Angiotensin II type 1 and Endothelin A Receptor
Authors: Tsirigotis Panagiotis , Vythoulkas Dionysios , Lazana Ioanna , Kroupis Christos , Gavriilaki Eleni , Konstantellos Ioannis , Bousiou Zoi , Chondropoulos Spyros , Griniezaki Marianna , Vardi Anna , Gkirkas Konstantinos , Karagiannidou Angeliki , Batsis Ioannis , Stamouli Maria , Sakellari Ioanna 
Published: February 2023

Abstract
Transplant associated thrombotic microangiopathy (TMA) occurs in a significant percentage of patients after allogeneic stem cell transplantation (allo-SCT) and is associated with significant morbidity and mortality. The aim of the present study was to examine the association of serum angiopoetin-2 (Ang2) levels, and the presence of antibodies against Angiotensin II type 1 (AT1R) and Endothelin A Receptor (ETAR) with the outcome of patients with TMA and/or graft-versus-host disease (GVHD) after allo-SCT. Analysis of our data showed that elevated serum Ang2 levels at the time of
TMA diagnosis are significantly associated with increased non-relapse mortality and decreased overall survival. To our knowledge this is the first study demonstrating an association between raised Ang2 levels and poor outcomes in patients with TMA. Antibodies against AT1R (AT1R-Abs) and ETAR (ETAR-Abs) were detected in 27% and 23% of the patients, respectively, but there was no association between the presence of autoantibodies and the outcome of patients with TMA. However, a significant finding was the strong positive correlation between the presence of AT1R-Abs with the occurrence of chronic fibrotic GVHD such as scleroderma and cryptogenic organizing pneumonia, raising the possibility of the contribution of autoantibodies in the pathogenesis of fibrotic GVHD manifestations.
The Risk of Developmental Dysplasia of the Hip in Premature Infants with Breech Presentation at Birth
Authors: Osman Ahmed , Jackson Kenneth , Conroy Sara , Seguin John , Slaughter Jonathan 
Published: February 2023

Abstract
Objective: To evaluate the probability of developmental dysplasia of the hip (DDH) in premature infants undergoing hip ultrasound (HUS) for breech presentation only, and for other indications.
Methods: Retrospective study of infants born between 01/01/2009 and 12/31/2018 at <37 weeks gestation with HUS in the first year of life. We calculated risk differences and odds ratios of DDH by the indication of HUS.
Results: From 2,397 infants analyzed, 89% underwent HUS for breech presentation only. The probability of DDH for infants undergoing HUS for breech only indication was 15 per 1,000 compared to 155 per 1,000 for infants undergoing HUS for other indications. The odds ratio of DDH diagnosis was 12.1 (95% CI: 7.5, 19.6) when the indication for HUS was not breech only relative to breech only.
Conclusion: The risk of DDH in premature infants with breech presentation is low. Screening these infants with physical examination may be sufficient.
Identification of tRNA-derived small RNAs expression profiles and their potential functions in age-related cataract
Authors: Liu Jinxia , Zhang Chengshou , Jiang Luyang , Hu Jianghua , chen Silong , Guo Jiarui , Yu Yibo 
Published: February 2023

Abstract
Object: To identify the expression profiles and demonstrate the potential functions of tRNA-derived small RNAs (tsRNAs) in the formation of age-related cataract (ARC).
Methods: Human lens epithelial cell line (HLE-B3 cells) were treated with H2O2, small RNA sequencing analysis was performed to identify expression profiles of tsRNAs in control and H2O2-treated HLE-B3 cells. Then, GO and KEGG enrichment analysis were employed to illustrate the potential functions of differentially expressed (DE) tsRNAs and target genes in ARC. Finally, quantitative real-time PCR assay was used to verify the expression patterns of DE tsRNAs.
Results: Totally 604 DE tsRNAs (329 upregulated and 275 downregulated) were obtained between control and H2O2-treated HLE-B3 cells. Bioinformatic analysis results showed that calcium signaling pathway may mainly participate in the formation of ARC.
Conclusion: Our results indicated that tsRNAs may be associated with the pathogenesis of ARC, and thus might be potential diagnostic and therapeutic targets for ARC.
Shor's Algorithm – How Does it Work on Perfect Squares
Authors: L Radhika T S , T Raja Rani 
Published: February 2023

Abstract
It is well known that Shor's algorithm is a revolutionary quantum algorithm designed to find the two prime factors of a large integer that is a product of these primes. Since then, several research groups have worked on implementing this algorithm, but for factorizing numbers like 15, 21, 35, etc., because of quantum hardware's limitations in efficiently handling many qubits. All these examples are similar in the sense that they are expressible as the product of two distinct prime factors. However, in this paper, we attempt to implement Shor's algorithm for a perfect square, say, 49, and present our observations.
FORMAÇÃO DE PROFESSORES PARA O ENSINO SUPERIOR: DOCÊNCIA NA CONTEMPORANEIDADE.
Authors: David Ricardo Santos 
Published: February 2023

RESUMO: Este artigo fala sobre os desafios do trabalho docente no ensino superior e sobre as práticas docentes necessárias para que as ações de ensinar e de aprender sejam verdadeiramente realizadas de forma a possibilitar a construção do conhecimento no ambiente da instituição de ensino superior na atualidade. Aqui são mostrados os desafios perante os alunos de hoje devido às suas mudanças de comportamentos, de prioridades e da importância que dão para a aprendizagem formal. Questões como: O que é ensinar? E o que é aprender nos dias atuais? Quais estratégias de ensinagem são necessárias para o efetivo aprendizado dos alunos, quais características o docente precisa apresentar para ser considerado um profissional competente, como está o ensino superior na atualidade, quem são os alunos ingressantes no ensino superior e o que buscam e como estes alunos se relacionam com os professores e com a instituição de ensino superior na Era da Informação, estão presentes neste artigo. O desenvolvimento de capacidades e habilidades de pensar e aprender estruturados dentro de um ambiente adequado é necessário para promover mudanças e inovações, levando a uma melhoria significativa dentro de sala de aula. Os cursos de ensino superior devem dar o suporte para os novos profissionais e cidadãos. Somente com a prática e desenvolvimento da atividade intelectual realizada de forma concreta e participativa tem-se a formação do ser integral. A metodologia do ensino superior deve levar o estudante a entender os mecanismos que levam ao aprendizado de forma consciente e independente. Palavras-chave: Educação Superior; Atuação Docente; Modernidade; Profissão Docente.
O núcleo argumentativo da Filosofia Política Medieval e a transição para a modernidade
Authors: Mariano Pires Felipe Augusto 
Published: February 2023

Este trabalho analisou as funções atribuídas à vontade e à virtude na teoria das formas de governo medieval e de transição para a Modernidade em relação com a possibilidade de participação do povo no poder. A análise partiu de quatro pilares, a teoria das formas de governo, a ideia do bem comum, a ideia de tirania do povo e o que foi chamado de núcleo argumentativo da filosofia política. Através da comparação dos autores selecionados, chegamos ao núcleo argumentativo desta época. O núcleo medieval realiza uma pequena alteração no núcleo antigo, identificando a virtude com a vontade de Deus, colocando, desta forma, a Igreja Católica acima dos poderes terrenos, como detentora da virtude. A transição do núcleo medieval para o moderno começou ainda no medievo e se aprofundou através da desconfiança na virtude, da valorização da vontade terrena e do ataque à virtude da Igreja.
PALAVRAS-CHAVES: Política – Medievo – poder – povo.
USO DITADO CONTEXTUALIZADO COMO FERRAMENTA PEDAGÓGICA PARA ALFABETIZAÇÃO DOS ALUNOS COM DISLEXIA
Authors: MARTINS CARDOSO SIDIRNEIDE SIMÕES , Ventin Bomfim Luciano Sérgio 
Published: February 2023

O trabalho ora apresentado versa sobre processo de alfabetização de alunos disléxicos ou com dificuldades específicas na aquisição da leitura e escrita, e a proposta aqui apresentada diz respeito a criar uma alternativa de ensino que estimule o aluno a realizar leitura de livros paradidáticos, e utilize este gênero textual ( contos), como um instrumento facilitador com uso do ditado contextualizado, que motive a consciência fonética na elaboração das hipóteses de escrita dos alunos com base na leitura realizada. Neste sentido, o objetivo geral centra-se em analisar o ditado contextualizado como uma estratégia de ensino aprendizagem, e sua importância no processo da aquisição da leitura e escrita dos alunos que apresentem dificuldades e limitações específicas de assimilação. Os objetivos específicos estão focados em : Identificar estratégias diferenciadas com uso do ditado contextualizado para alfabetização dos alunos; compreender o uso do ditado contextualizado como um instrumento pedagógico facilitador na elaboração das hipóteses de escrita dos alunos por meio da consciência fonética. A metodologia utilizada foi a pesquisa bibliográfica qualitativa, com buscas em plataformas dos Periódicos da Capes e Scielo, visando a busca de teóricos que falam sobre as temática e o processos de alfabetização de alunos com dificuldades específicas na aquisição da leitura e escrita.O resultado esperado colaborar para o processo alfabetização, e aquisição da leitura e escrita dos alunos, e apresentar uma alternativa de trabalho para auxiliar professores no atendimento ao alunos com dificuldades específicas por meio do ditado contextualizado, na educação básica.
Entropy-statistical analysis of the efficiency of cycles of refrigeration units of household refrigerators
Authors: Kudrov Yu. V. 
Published: February 2023

Objective. The aim of the work is to determine the thermodynamic efficiency of the modernized refrigeration unit of a household refrigerator compared to the basic model using the entropystatistical method.Method. В ходе работы при проведении исследований применен научный метод системного анализа, а также энтропийно-статистический метод термодинамического анализа при определении эффективности холодильного цикла бытового холодильника.Result. The analysis of the distribution of energy costs to compensate for the production of entropy by the nodes of the refrigeration unit is carried out. This analysis allows us to visually assess the energy losses in the cycle of a household refrigerator. The analysis was carried out for the most popular refrigerants R134a and R600a when used in household refrigerators. Based on the calculations carried out, comparative diagrams of energy losses in cycle processes are constructed. The entropy-statistical analysis of the thermodynamic efficiency indicators of the cycle confirms the advantages of the modernized refrigeration unit of the household refrigerator.statistical method.Conclusion. In the course of the work, it was confirmed that the use of an upgraded refrigeration unit will reduce the total energy costs, and the chosen research method will visually assess the energy losses for the elements of the refrigeration unit cycle.
Technical solutions for the recycling of thermal energy and improving the environmental efficiency of engineering systems
Authors: Neverov E. N. , Korotkiy I. A. , Korotkih P. S. , Mokrushin M. Y. , Porokhnov A. N. 
Published: February 2023

Objective. The article proposes design solutions aimed at the comprehensive modernization of the cold supply system of the ice palace "Puck" in Sochi, to reduce its impact on the environment.Method. A water reuse system has been created and a technology has been developed for using low-temperature heat that is released during the operation of the refrigeration machine.Result. A refrigeration plant has been developed that allows you to utilize, accumulate and direct the heat of condensation for the secondary use of thermal energy by other engineering systems at the facility, thereby reducing heat and greenhouse gas emissions into the Earth's atmosphere and increasing the technological capabilities of cooling.Conclusion. The proposed methods make it possible to make the necessary calculations and select equipment for the implementation of the developed systems in ice arenas.
Calculation of a thermoelectric unit as part of a system for conducting thermal physiotherapy procedures
Authors: Evdulov O. V. , Khazamova M. A. , Abdulkhakimov U. I. , Gamzalova I. Yu. , Gabitov I. A. 
Published: February 2023

Objective. The aim of the study is to consider the methodology for calculating a thermoelectric unit as part of a thermoelectric system (TPS) intended for thermal exposure in medical practice, as well as the results of a numerical experiment carried out using it.Method. The calculation model of the thermoelectric block, which is part of the system for conducting thermal physiotherapy procedures, is described. The model is built on the basis of standard expressions for calculating the electrical and geometric parameters of thermoelectric modules (TEM) depending on the thermal and electrical parameters of thermoelement (FC) materials, heat and cooling capacity values, and characteristics of heat removal systems from FC hot junctions.Result. According to the calculation model, the thermoelectric unit was calculated, which is part of the system for conducting thermal cosmetic procedures, developed in the laboratory of semiconductor thermoelectric devices and devices of the Daghestan State Technical University on the temperature difference between the junctions for different values of the supply current, as well as the dependence of the voltage on the TEM on the magnitude of the supply current at different values of the temperature difference between the junctions, the change in temperature at the cold junction and the power of the TEM on the supply current. The graphs are calculated at a hot junction temperature of 320 K.Conclusion. As a result of calculations, it was found that the operating power range of TEMs of the TV-127-1.4-2.5 type is in the range from 8 to 17 W with an average temperature difference between the junctions of 45 K. In this case, the supply current will be 1 .5-3.5 A with a power consumption of 20 to 80 watts. The refrigerating coefficient varies from 0.1 to 0.5. In accordance with the tasks to be solved, the thermoelectric unit of the device should include four TEMs of this type.
Method for decomposition a global task into local tasks through the process of collective decision making in swarm robotic systems
Authors: Petrenko V. I. , Tebueva F. B. , Antonov V. O. , Ryabtsev S. S. , Pavlov A. S. 
Published: February 2023

Objective. The purpose of the work is to increase the efficiency of the process of task allocation through preliminary decomposition and prioritization of tasks based on the process of collective decision-making (CDM) in swarm robotic systems (SRS).Method. Task decomposition implemented using a hybrid decision-making strategy, the majority principle of changing opinions using distributed registry technology for disseminating opinions among SRS agents and aggregating accumulated knowledge about the functioning environment. An element of scientific novelty is the proposed SRS procedure, which provides the possibility of assessing the priority of tasks, which in turn improves the efficiency of the SRS agents.Result. Software implementation of the proposed method made in the C++ programming language. For the experiments, the scenario of collective perception by SRS agents in a specialized simulation environment ARGoS was used.Conclusion. The method implemented using the solutions proposed in the work turned out to be more efficient than the method based on the greedy algorithm. The proposed solutions can be used not only in SRS, but also in any other robotic systems with decentralized control, designed to monitor and control environmental parameters.
Analysis of information security technologies for use in the enterprise infrastructure
Authors: Popov A. D. , Popova A. D. 
Published: February 2023

Objective. The purpose of the study is to analyze modern information security technologies for solving the problems of protecting information in the enterprise infrastructure.Method. The study is based on the methods of system analysis, synthesis, deduction.Result. The analysis was carried out and the features of information protection technology were disclosed for the purpose of possible use in the infrastructure of the enterprise. The analysis of domestic and foreign software for practical use is carried out.Conclusion. The results of the analysis reveal the features of using information protection tools in the enterprise infrastructure in order to counteract modern vectors of attacks on information resources.