bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemistry and Biological Assessment of Thuja articulata Trunk Barks:
HPLC-PDA-ESI-MS Analysis, Bioevaluation, and Molecular Docking
Authors: Algethami Faisal K. , Jlizi Salma , Znati Mansour , Elamin Mohamed R. , Ben Hamadi Naoufel , Ben Jannet Hichem 
Published: June 2023

Background:
Thuja articulata is a Mediterranean forest species from the Cupressaceae family, it has been used in popular medicine to treat several diseases. Various studies have been carried out in vitro using diverse T. articulata extracts to understand its traditional use.

Methods:
In this study, the ethyl acetate extract of T. articulata trunk barks was chemically identified
using HPLC-PDA-ESI-MS, then examined in vitro for its antioxidant and α-amylase inhibitory
effects. A molecular docking study was also performed to reinforce the noted bioactivities.

Results:
HPLC-PDA-ESI-MS analysis led to the identification of 22 polyphenolic compounds
in the ethyl acetate extract of T. articulata trunk barks. This extract revealed interesting in vitro
antioxidant properties and a significant α-amylase inhibitory action (IC50 = 16.08 ± 1.27 μg/mL).
In silico analysis was found to agree with the in vitro studies in which major constituents of the
ethyl acetate extract revealed low binding energy and a correct mode of interaction in the active
pocket of the enzyme (PDB: 7TAA). The anti-a-amylase potential could be due either to a synergistic
or individual action of certain constituents present in this extract.

Conclusion:
This study illustrates that the ethyl acetate extract of T. articulata trunk barks has
potent sources of antioxidants and α-amylase inhibitors to be explored.
In silico Screening and Validation of Achyranthes aspera as a Potential Inhibitor of
BRAF and NRAS in Controlling Thyroid Cancer
Authors: Alamri Ahmad M. , Alkhilaiwi Faris A. , Khan Najeeb U. , Tasleem Munazzah 
Published: June 2023

Background:
Thyroid carcinoma (THCA) is one of the most prevalent endocrine tumors, accounting for
3.4% of all cancers diagnosed annually. Single Nucleotide Polymorphisms (SNPs) are the most prevalent genetic variation
associated with thyroid cancer. Understanding thyroid cancer genetics will enhance diagnosis, prognosis, and
treatment.

Methods:
This TCGA-based study analyzes thyroid cancer-associated highly mutated genes through highly robust in
silico techniques. Pathway, gene expression, and survival studies were performed on the top 10 highly mutated genes
(BRAF, NRAS, TG, TTN, HRAS, MUC16, ZFHX3, CSMD2, EIFIAX, SPTA1). Novel natural compounds from
Achyranthes aspera Linn were discovered to target two highly mutated genes. The natural compounds and synthetic
drugs used to treat thyroid cancer were subjected to comparative molecular docking against BRAF and NRAS targets.
The ADME characteristics of Achyranthes aspera Linn compounds were also investigated

Results:
The gene expression analysis revealed that the expression of ZFHX3, MCU16, EIF1AX, HRAS, and NRAS was
up-regulated in tumor cells while BRAF, TTN, TG, CSMD2, and SPTA1 were down-regulated in tumor cells. In addition,
the protein-protein interaction network demonstrated that HRAS, BRAF, NRAS, SPTA1, and TG proteins have
strong interactions with each other as compared to other genes. The ADMET analysis shows that seven compounds
have druglike properties. These compounds were further studied for molecular docking studies. The compounds
MPHY012847, IMPHY005295, and IMPHY000939 show higher binding affinity with BRAF than pimasertib. In addition,
IMPHY000939, IMPHY000303, IMPHY012847, and IMPHY005295 showed a better binding affinity with
NRAS than Guanosine Triphosphate.

Conclusion:
The outcomes of docking experiments conducted on BRAF and NRAS provide insight into natural compounds with pharmacological characteristics. These findings indicate that natural compounds derived from plants as a more promising cancer treatment option. Thus, the results of docking investigations conducted on BRAF and NRAS substantiate the conclusions that the molecule possesses the most suited drug-like qualities. Compared to other compounds, natural compounds are superior, and they are also druggable. This demonstrates that natural plant compounds can be an excellent source of potential anti-cancer agents. The preclinical research will pave the road for a possible anti-cancer agent.
Integrating democracy learning and prophetic social studies at Baitusalam Islamic School Yogyakarta
Authors: Nasiwan Nasiwan , Wulandari Taat , Wijayanti Agustina Tri 
Published: June 2023

This paper describes an attempt to integrate Islamic and scientific values into social studies education with the aim of developing prophetic social science theory to explain social problems from this perspective. The study focuses on the implementation of this theory at Baitusalam Islamic School in Yogyakarta, using qualitative research methods such as observation, interviews, and documentation. The findings suggest that social studies learning Islamic values that develop boarding power, with the learning process incorporating these values into planning, implementation, and assessment. However, the study also identifies challenges in the integration process, such as the lack of student textbook references that integrate values into Islamic language for each material, insufficient learning media, and inadequate infrastructure in schools. Overall, this study highlights the importance of integrating Islamic and scientific values into social studies education to develop young people's sense of nationalism, independence, and character, while acknowledging the need to address these challenges for effective implementation.
The Role of Board Financial Monitoring Strength and Donor Pressure in Nonprofit Auditors’ Assessment of Changes in Program Expense Allocations
Authors: Lauck John R. , Bhattacharjee Sudip 
Published: June 2023

SUMMARY
Nonprofits face inherent risks from both donor pressure to increase program spending and a high propensity for reporting errors. Simultaneously, in contrast to for-profit settings, limitations of nonprofit governance can raise auditors’ concerns about a board’s effectiveness as a control mechanism. We experimentally examine how a nonprofit board’s stronger and weaker monitoring strength influences auditors’ assessments of a client’s program expense allocations under conditions of higher and lower donor pressure to increase program spending. Auditors assess management’s expense allocations as more appropriate, and document fewer risk factors, only when board financial monitoring is strong and donor pressure is lower. Further, auditors rely on strong boards to reduce errors, but not intentional misstatements related to management’s allocation of functional expenses. These findings suggest that, in contrast to how auditors use for-profit governance, auditors may question the ability of even strong nonprofit boards to mitigate instances of intentional functional expense allocation misreporting.
The Effects of Transparency and Group Incentives on Managers’ Strategic Promotion Behavior
Authors: Hecht Gary , Maas Victor S. , van Rinsum Marcel 
Published: June 2023

ABSTRACT
We investigate managers’ propensity to engage in strategic promotion behavior. Strategic promotion behavior occurs when managers pursue personal economic interests when contributing to employee promotion decisions, such that the probability that relatively lower performing employees are selected for a promotion is increased. We develop theory about how two important organizational characteristics—transparency about individual performance levels and the presence of group incentives—jointly affect managers’ tendency to strategically influence promotion decisions. Using a stylized lab experiment, we find that transparency about individual performance levels decreases strategic promotion behavior when group incentives are absent but not when group incentives are present. We discuss how our findings contribute to our understanding of management accounting and control systems.
Narrative operative reports inconsistently record surgical information relating to resection of soft tissue sarcomas and mast cell tumors in dogs
Authors: O’Neill Meaghan , Wustefeld-Janssens Brandan G. , Tremolada Giovanni , Griffin Maureen 
Published: June 2023

Abstract

OBJECTIVE
To report to what degree narrative operative reports for soft tissue sarcoma (STS) and mast cell tumor (MCT) resections met a predetermined template made up of essential elements.

ANIMALS
197 consecutive client-owned animals between May 1, 2017, and August 1, 2022.

PROCEDURES
A consensus list of 9 elements made up the final synoptic operative report (SR) template. Consecutive narrative surgery reports (NRs) of dogs that underwent MCT or STS resection were then reviewed to determine how many of the SR elements were present in each NR. A score was then determined for each NR out of a maximum total of 9.

RESULTS
Overall, 197 reports (99 MCT and 98 STS) were included. The median score was 5 (56% of elements reported). No report had all 9 elements, and 1 report had none of the elements reported. When MCT and STS were analyzed independently, the median score was 6 (67% of elements reported) for MCT and 5 (56% of elements reported) for STS. There was a trend of more cases with MCT that had a preoperative diagnosis, intraoperative measurements of the tumor, and surgeon margins marked compared to dogs with STS. More dogs with STS had an estimated Enneking dose compared to dogs with MCT.

CLINICAL RELEVANCE
Our data show that essential elements of STS and MCT resection in dogs were inconsistently recorded and no case had all elements present. This mirrors data in people and presses the need for more standardization in reporting of cancer operations in veterinary medicine.
Knee- and Overall Health-Related Quality of Life Following Anterior Cruciate Ligament Injury: A Cross-sectional Analysis of Australian and Canadian Cohorts
Authors: Patterson Brooke E. , Emery Carolyn , Crossley Kay M. , Culvenor Adam G. , Galarneau Jean-Michel , Jaremko Jacob L. , Toomey Clodagh M. , Guermazi Ali , Whittaker Jackie L. 
Published: June 2023

OBJECTIVE: To describe the knee- and overall health-related quality of life (QOL) 3 to 12 years after anterior cruciate ligament (ACL) tear, and to assess the association of clinical and structural features with QOL after ACL tear. DESIGN: Cross-sectional analysis of combined data from Australian (n = 76, 5.4 years postinjury) and Canadian (n = 50, 6.6 years postinjury) prospective cohort studies. METHODS: We conducted a secondary analysis of patient-reported outcomes and index knee magnetic resonance imaging (MRI) acquired in 126 patients (median 5.5 [range: 4–12] years postinjury), all treated with ACL reconstruction. Outcomes included knee (ACL Quality of Life questionnaire [ACL-QOL]) and overall health-related QOL (EQ-5D-3L). Explanatory variables were self-reported knee pain (Knee Injury and Osteoarthritis Outcome Score [KOOS-Pain subscale]) and function (KOOS-Sport subscale), and any knee cartilage lesion (MRI Osteoarthritis Knee Score). Generalized linear models were adjusted for clustering between sites. Covariates were age, sex, time since injury, injury type, subsequent knee injuries, and body mass index. RESULTS: The median [range] ACL-QOL score was 82 [24–100] and EQ-5D-3L was 1.0 [−0.2 to 1.0]. For every 10-point higher KOOS-Sport score, the ACL-QOL score increased by 3.7 points (95% confidence interval [CI]: 1.7, 5.7), whereas there was no evidence of an association with the EQ-5D-3L (0.00 points, 95% CI: −0.02, 0.02). There were no significant association between KOOS-Pain and ACL-QOL (4.9 points, 95% CI: −0.1, 9.9) or EQ-5D-3L (0.05 points, 95% CI: −0.01, 0.11), respectively. Cartilage lesions were not associated with ACL-QOL (−1.2, 95% CI: −5.1, 2.7) or EQ-5D-3L (0.01, 95% CI: −0.01, 0.04). CONCLUSION: Self-reported function was more relevant for knee-related QOL than knee pain or cartilage lesions after ACL tear. Self-reported function, pain, and knee structural changes were not associated with overall health-related QOL. J Orthop Sports Phys Ther 2023;53(7):402–413. Epub: 8 June 2023. doi:10.2519/jospt.2023.11838
Molecular characterization and epidemiology of methicillin-resistant Staphylococcus aureus isolated from clinical samples in Sokoto, Nigeria
Authors: Umar Asiya Imam , Manga Shuaibu Bala , Baki Aliyu Sarkin , Uba Ahmad 
Published: June 2023

Objectives:
Methicillin-resistant Staphylococcus aureus (MRSA) is a major public health threat and a cause of hospital-acquired and community-acquired infections. This study was undertaken to investigate antimicrobial resistance pattern, the genetic lineage, presence of S. aureus protein A (SPA) gene, and staphylococcal chromosomal cassette mec (SCC mec) types of MRSA isolated from clinical samples sent for microbiological test in major government hospitals in Sokoto.

Material and Methods:
A total of 90 S. aureus MRSA isolates were collected and confirmed using standard microbiological techniques. Antibiotic susceptibility testing was done using the disk diffusion method; mecA detection and sequencing were carried out. Phylogenetic reconstruction was also done using the molecular evolutionary genetics analysis X software and phylogeny tree constructed by Neighbor-Joining method. SCC mec typing and SPA detection were also done.

Results:
Of the 90 S. aureus isolates, 42 were found to be MRSA using the cefoxitin disk diffusion, the most potent antibiotic against them was quinupristin/dalfopristin with 83.3% followed by rifampicin with 81.0% and 6 clindamycin with a 71.4%. With 78.6% of the isolates showing resistance to the fluoroquinolone antibiotic ciprofloxacin, tetracycline and gentamicin came in second and third, with 64.3% and 61.9% of isolates showing resistance, respectively. Most of the MRSA isolates were resistant to more than three antibiotics. Polymerase chain reaction showed 36 (85.7%) harbored the mecA gene and of the 36 mecA positive isolates, phylogenetic reconstruction of representative MRSA sequences showed that MRSA sequences in this study clustered in two closest clades suggesting a possible horizontal transfer. Of the 36 isolates, 23 were SCC mec type I, ten were type IV, and three were non-typeable, while the SPA gene was detected in all the isolates amplified.

Conclusion:
The use of phenotypic and molecular methods in this study provided useful information on antibiotic resistance profile, epidemiology, and molecular characteristics of MRSA isolates in Sokoto Nigeria. The information provided could help in monitoring the evolution of MRSA strains in Nigeria over time.
Uji Kelayakan E-LKPD Berbasis PBL (Problem Based Learning) Untuk Meningkatkan Keterampilan Proses Sains Peserta Didik SMA
Authors: Khairunnisa Novia , Purwanto Andik , Medriati Rosane 
Published: June 2023

This study aims to determine the validity of PBL (Problem Based Learning) based E-LKPD to improve the science process skills of high school students. By using the type of R&D (Research and Development) method and consists of a process of (1) Analysis, (2) Design, and (3) Develop. This research instrument is a material expert validation sheet and a media expert validation sheet to determine the validity of E-LKPD. This study tested of E-LKPD with static electricity class XII material and was conducted at SMA Negeri 3 Bengkulu City, SMA Negeri 4 Bengkulu City, and SMA Negeri 9 Bengkulu City. Based on the data analysis that has been done, it is found that the results of the material E-LKPD validation are 88,3% with worthy criteria. While the results of media E-LKPD validation are 80% with worthy criteria. While the material reliability test results are 79% with reliable criteria and the media reliability test results are 94% with reliable criteria. So, it can be concluded that the PBL (Problem Based Learning) based E-LKPD to improve the science process skills of high school students is said to be worthy. Keywords: feasibility test of E-LKPD, PBL, Science Process Skills.
Peningkatan Kapasitas Pramu Saji Terkait CHSE (Cleanliness, Health, Safety & Environment Sustainability) dan Pelayanan Prima Pada Restaurant di Kawasan Wisata Tanjung Bias Desa Montong Kecamatan Batu Layar, Kabupaten Lombok Barat
Authors: Chaidir Taufiq , Ayu Putri S Ida , Ayu Arini Gst , Ismiwati Baiq 
Published: June 2023

Covid-19 yang melanda dunia sejak 2019 berdampak pada semua aspek dalam kehidupan manusia, salah satunya adalah pada kegiatan pariwisata, hal ini terindikasi dari pola perubahan permintaan wisatawan terhadap : kesadaran kebersihan , kesehatan , keselamatan dan kelestarian pada destinasi wisatawan termasuk pada restaurant. Oleh karenanya pelaku pariwisata harus mengetahui dan menerapkan prinsisp yang dikenal dengan CHSE (Cleanliness, Health, Safety & Environment Sustainability) serta pelayanan prima. Terkait dengan hal tersebut maka dilakukan pengabdian pada masyarakat pada pelaku usaha restaurant dan pramu saji yang berada pada destinasi pariwisata Tanjung Bia, hal ini disebabkan karena berdasarkan hasil observasi 75 % dari pelaku usaha restaurant dan pramu saji belum mengetahui prinsip CHSE dan belum menerapkan pelayanan prima. Metode pelaksanaan pengabdian masyarakat yang digunakan adalah pertama mengobservasi sasaran target kemudian memberikan materi penyuluhan terkait dengan CHSE serta pelayanan prima dengan menggunakan metode partisipatif serta melakukan evaluasi dan monitoring terhadap hasil kegiatan. Hasil pengabdian menunjukkan bahwa pertama, peserta tidak mengetahui apa yang dimaksud dengan CHSE dan pelayanan prima. Hal ini terlihat dari diskusi yang dilakukan dimana peserta tidak mengetahui bagaimana cara menyajikan makanan dan minuman, tidak mengetahui pentingnya pelayanan prima. Kedua, peserta kurang menyadari pentingnya produk yang sehat, aman proses produksinya serta kurang menyadari pentingnya kelestarian lingkungan. Namun demikian respon peserta pada kegiatan ini sangat baik, terlihat dari berbagai pertanyaan yang disampikan dan juga pada saat mereka mempraktekkan cara penyajian makanan dan minuman serta peserta bersedia menularkan pengetahuan yang diperolehnya pada pramu saji lainnya diseputar Kawasan Wisata Tanjung Bias.
The Potential of Averrhoa bilimbi Juice As An Alternative Reagent in Proteinuria Examination
Authors: Kristinawati Erna , Nur Nutri Farda , Hasanah Idyatul 
Published: June 2023

Background: Proteinuria indicates a kidney disorder and provides important prognostic information in diagnosing kidney disease. To determine the presence of protein in the urine, a urinalysis examination is carried out. Proteinuria examination generally uses the heating method with acetic acid, sulfosalicylic acid, and concentrated nitric acid as reagents. In Indonesia, the use of acetic acid for proteinuria examination is still the primary choice. An alternative reagent is needed that can replace the function of acetic acid. The objective of this study is to determine the potential of Averrhoa Blimbi juice as an alternative reagent for proteinuria examination.Methods: This was a Pre-experimental study with a completely randomized design. This study used urine samples from a patient with chronic kidney disease. Urine samples were examined using 6% acetic acid reagent as a control and using Averrhoa bilimbi juice with various concentrations. Each juice concentration was examined twice so that the experimental units in this study were 40 units. The Kruskal-Wallis test was used to determine the potential of Averrhoa bilimbi as an alternative reagent.Results: At concentrations of 5%-20% showed the same positive results as 6% acetic acid, namely +2, concentration 25%-35% resulted in +3, and other concentration resulted in +4. The results of data analysis showed p=0.04 (p<0.05). This shows that Averrhoa bilimbi has the potential as an alternative reagent for proteinuria examination.Conclusion: Averrhoa bilimbi juice with a 5%-20% concentration has the potential as an alternative reagent for 6% acetic acid to check proteinuria levels.Keywords: Averrhoa bilimbi ; alternative reagents; proteinuria; acetic acid; urinalysis
Pemanfaatan Teri Jengki (Stolephorus indicus) Dan Layang Deles (Decapterus macrosoma) Sebagai Media Alternatif Pertumbuhan Escherichia coli
Authors: Nurhasanah Armelia Gitasari , Pestariati Pestariati , Anggraini Anita Dwi , Astuti Sri Sulami Endah 
Published: June 2023

ABSTRAK Nutrient agar merupakan jenis media umum yang sering digunakan pada laboratorium, harga media ini relatif mahal. Nutrient agar berbentuk padat, terdiri atas campuran ekstrak daging, pepton serta agar. Ikan teri jengki dan ikan layang deles jumlahnya melimpah di Indonesia. Ikan teri jengki (Stolephorus indicus) mengandung protein 51.54%, sementara ikan layang deles (Decapterus Macrosoma) mengandung protein sebesar 57,89%. Escherichia coli digunakan sebab bakteri ini merupakan salah satu jenis mikroorganisme kontrol positif yang direkomendasikan berdasarkan Data Sheet Nutrient Agar OXOID. Penelitian ini bersifat eksperimental dengan tiga perlakuan pada masing-masing bahan yaitu variasi massa 3 gram, 4 gram dan 5 gram yang dilakukan di Laboratorium Bakteriologi Jurusan Teknologi Laboratorium Medis Poltekkes Kemenkes Surabaya. Hasil penelitian menunjukkan jumlah koloni rata-rata Escherichia coli yang tumbuh pada kontrol positif sebanyak 118 x 1013, sementara pada media ikan teri jengki variasi massa 3 gram adalah 72 x 1013 CFU/mL, 4 gram sebanyak 85 x 1013 CFU/mL, 5 gram sebanyak 94 x 1013 CFU/mL. Pada media ikan layang deles variasi 3 gram sebanyak 88 x 1013 CFU/mL, 4 gram sebanyak 96 x 1013 CFU/mL, 5 gram 108 x 1013 CFU/mL. Variasi massa yang paling baik dan mendekati hasil kontrol positif (nutriet agar) pada ikan teri jengki dan ikan layang deles adalah variasi massa 5 gram.Kata kunci: ikan teri jengki, ikan layang deles, Escherichia coli, nutrient agar
التّسامح اللغويّ عند الجاحظ (ت255هـ)
Authors: عبد المهدي جاسم الوائلي أ.م.د. جمانة 
Published: June 2023

إنّ الجاحظَ من الأقلّاء الأكْفَاء الذين ملكوا لغة عالية مكّنته من امتلاك ناصيتها، وفطنة أعانته على اشتقاق الصيغ، وتوليد المعاني التي لم تعرفها اللغة من قبل الجاحظ، ولم ترد عن سواه.
والمتطلع في تراث الجاحظ الضخم يجد كثيرا من هذه الصيغِ، والمعاني التي تفرّد بها عن غيره، تدفعه إلى ذلك جرأته واعتداده بفكره الذي أباح للسانه أن يستعمل في كتاباته من الكلم العربي ما لم يكن فيه، ولم يرد في أمّات المعاجم ومتون اللغة.
ومن هنا عنّ لي أنّ في أسلوبه غرابة وفي تراكيبه لباقة، وكثيرا ما يأتي بلفظ هو محطّ شكّ وظنة في قواعد العربيّة وسننها، فاستوت عندي مادّة هي أهل للمفاتشة والمباحثة في الجانب الصرفيّ والنحويّ والدلاليّ، وسَمته بـ "التسامح اللغويّ عند الجاحظ" لأقف على هذه الميزة التي أكثر منها الجاحظ في كتاباته.