bluuebunny/crossref_metadata_2025_split huggingface dataset:
A snapshot of social activities programs in residential aged care facilities in Victoria: A brief report
Authors: Clune Samantha , Rayner Jo , McAuliffe Linda , Fetherstonhaugh Deirdre 
Published: March 2023

AbstractObjectivesTo capture current opportunities for social participation for older people living in residential aged care in Victoria, Australia.MethodsA postal survey of all 766 Victorian residential aged care facilities. Respondents were asked to outline the nature of social participation opportunities available to residents, any potential barriers to inclusion and organisational commitments such as funding allocations and staff fractions.ResultsSurveys were returned by 153 facilities, representing a response rate of 20%. All facilities had a dedicated social program, although just over half (57%; 87 of 153) offered the social program over the weekend, usually on a Saturday morning only (90%). Barriers to older people's opportunities for social participation included their ineligibility to continue attending external community programs once entering residential aged care (86%), their illness (71%), carer availability (50%) and lack of funding (42%). Funding for almost all programs (128 of 153; 84%) was described as internal and ad hoc, and staff allocations for the program were almost entirely fractional. Only 12 (8%) facilities reported that they had a dedicated full‐time coordinator for the social participation program.ConclusionsSocial participation programs are available in Victorian residential aged care facilities. However, limited funding and staff allocations reduce the opportunities for older people to engage in meaningful social participation with others.
Legacy effects of canopy gaps on liana abundance 25 years later in a seasonal tropical evergreen forest in northeastern Thailand
Authors: Fujimoto Yutaro , Kanzaki Mamoru , Meunpong Ponthep , Wachrinrat Chongrak , Waengsothorn Surachit , Kitajima Kaoru 
Published: March 2023

AbstractLianas require host trees to reach and stay in the forest canopy, but as seedlings and juveniles, they benefit from canopy gaps created by treefalls. Here, we evaluated the relative importance of these two aspects, that is, the availability of potential hosts vs. the legacy effect of past treefall gaps, on the local abundance of liana stems in a seasonal tropical evergreen forest in the Sakaerat Biosphere Reserve in northeastern Thailand. Within a 2.5‐ha plot for forest dynamics monitoring, canopy height was measured in 1993 and 2018 at 5‐m intervals to distinguish areas of mature (canopy height ≥ 20 m), building (10–20 m), and gap phases (< 10 m). In 2017–2018, we surveyed all liana stems ≥ 1 cm in diameter at breast height within 50 subplots (10 m × 10 m each) and recorded their diameter and the diameter of the host tree. Of a total of 445 liana individuals, 242 could be identified at least to the family level, while the others had clear morphological traits of climbing mechanisms. The number of liana stems was higher in areas that had been at the building/gap phase than those at the mature phase in 1993. When this 25‐year‐old legacy of past gap locations was considered, there was a positive association of local abundance between lianas and trees in areas at the mature phase in 2018. In conclusion, liana abundance reflected a long‐term legacy of past treefall gaps more than 25 years earlier in this seasonal evergreen forest.
Rheumatoid neutrophilic dermatosis under treatment with the interleukin‐6‐receptor‐antagonist sarilumab in a patient with seropositive rheumatoid arthritis
Authors: Jost Marion , Schwarz Thomas , Wehkamp Ulrike , Bohne Ann‐Sophie , Drerup Katharina 
Published: March 2023

AbstractSkin manifestations may arise as adverse events following the use of novel drugs. We report a case of a patient with seropositive rheumatoid arthritis who developed a rheumatoid neutrophilic dermatosis (RND) under treatment with the interleukin‐6‐receptor‐antagonist sarilumab. The skin lesions developed 2–3 days after the first injection. RND presents with asymptomatic, symmetrical fixed urticarial‐like papules, plaques, and nodules, localized typically on the extensor surfaces of the forearms and hands. After discontinuing the medication, the nodules in our patient disappeared within a month.
Children in Denmark with cerebral palsy rarely complete elementary school
Authors: Pedersen Signe V. , Wiingreen Rikke , Hansen Bo M. , Greisen Gorm , Larsen Mads L. , Hoei‐Hansen Christina E. 
Published: March 2023

AbstractAimTo investigate how children with cerebral palsy (CP) perform in the Danish school system and which factors are associated with school performance.MethodThis was a population‐based cohort study including 463 126 children born from 1997 to 2003. Data were extracted from seven national registries. The study encompassed 818 children with CP (483 [59.0%] males, 335 [41.0%] females) and 417 731 without CP (214 535 [51.4%] males, 203 196 [48.6%] females). We evaluated two primary outcomes: not completing 10 years of elementary school, defined as attending fewer than eight final mandatory exams; and grade point averages (GPAs). Mann–Whitney U tests were used to analyse differences in GPAs and logistic regressions were used to calculate odds ratios (ORs).ResultsAmong children with and without CP, 62.6% and 12.4% did not complete elementary school respectively (OR = 11.85 [10.28–13.66]). Additionally, children with CP who attended all final exams achieved lower overall GPAs than children without CP (6.6 vs 7.3, p = 0.001). In children with CP, comorbidities, maternal education, severity of motor impairments, and intellectual deficits were associated with increased odds of not completing elementary school. Notably, one‐third of children with CP with apparent normal intelligence did not complete school, despite special educational measures.InterpretationDanish children with CP rarely complete elementary school despite initiatives for a more supportive educational system. The complexity of individual needs in children with CP may be challenging for an inclusive school environment.What this paper adds

Children with cerebral palsy (CP) have a high risk of not completing elementary school.
Children with CP achieve lower overall grades than children without CP.
Motor impairment, comorbidities, and maternal education are associated with poor school performance.
Intellectual impairment is the most important predictor of poor school performance.
Ultra rapid lispro showed greater reduction in postprandial glucose versus Humalog in children, adolescents and adults with type 1 diabetes mellitus
Authors: Aronson Ronnie , Biester Torben , Leohr Jennifer , Pollom Robyn , Linnebjerg Helle , LaBell Elizabeth Smith , Zhang Qianyi , Coutant David E. , Danne Thomas 
Published: March 2023

AbstractAimThis study compared the pharmacokinetics, glucodynamics and tolerability following single subcutaneous doses of ultra rapid lispro (URLi) versus Humalog in children (6‐11 years), adolescents (12‐17 years) and adults (18‐64 years) with type 1 diabetes mellitus (T1D).Materials and MethodsThe study was a randomized, two‐period, subject‐ and investigator‐blind, crossover design in participants with T1D. Participants received a 0.2 U/kg bolus dose immediately before a liquid mixed meal tolerance test. Insulin lispro and glucose concentrations were measured.ResultsThe study included 13 children, 14 adolescents and 15 adults. Consistently across the age groups, onset of appearance was 4‐5 min faster, the early 50% tmax was reduced by 7‐13 min, and exposure in the first 15 min was increased by 3.5‐6.5‐fold following URLi compared with Humalog (all p < .01). Exposure after 3 h was decreased by 37‐58% (p = .02) and the duration was reduced by 56 min (p = .006) in children and 36 min (p = .022) in adolescents with URLi compared with Humalog. The maximum and overall exposure were similar between treatments. Postprandial glucose at 1 h was reduced by 42 mg/dl in children (p = .008), 19 mg/dl (p = .195) in adolescents and 34 mg/dl (p = .018) in adults following URLi versus Humalog. The glucose excursion during a 5‐h test meal period was reduced by 16% in children and 9% in adolescents compared with Humalog. URLi was well tolerated in all age groups.ConclusionsURLi showed an accelerated insulin lispro absorption and greater postprandial glucose reduction compared with Humalog in children, adolescents and adults with T1D.
The relationship between echocardiographic parameters and albumin bilirubin (ALBI) score in patients with isolated secundum type atrial septal defect
Authors: Evlice Mert , Bedir Ömer , Coşkun Mükremin , Paçacı Emre , Cerşit Sinan , Öcal Lütfi , Gürsoy Mustafa Ozan , Şen Ömer , Kurt İbrahim Halil 
Published: March 2023

AbstractBackgroundIt has been shown that the increase in volume and pressure in the right heart chambers increases liver stiffness. The Albumin‐Bilirubin (ALBI) score is a useful and easy‐to‐use score for objectively assessing liver function. There is no information in the literature about changes in ALBI score in patients with atrial septal defect (ASD). The aim of our study is to investigate the changes in ALBI score and its clinical impact in patients with ASD.MethodsOf the 206 analyzed patients, 77 were excluded. The remaining 129 patients with secundum type ASD with left to right shunt were divided into three groups; Group I (16 patients with Qp/Qs < 1.5 and defect diameter < 10 mm), Group II (52 patients with Qp/Qs > 1.5 and defect diameter 10–20 mm) and Group III (61 patients with Qp/Qs > 1.5 and defect diameter > 20 mm). The ALBI score was calculated based on serum albumin and total bilirubin levels using the following formula: ALBI = (log10 bilirubin [umol/L] * .66) + (albumin [g/L] * ‐.085).ResultsALBI scores as well as total bilirubin levels, transaminases, and functional‐structural heart abnormalities (increase in RA and RV dimensions, sPAP, ASD size and decrease in LVEF and TAPSE) showed a significant increasing trend from Group I to Group III (p < .001 for all comparisons). The mean ALBI scores for Group I, Group II, and Group III were ‐3.71 ± .37, ‐3.51 ± .25, and ‐3.27 ± .34, respectively. In multivariate linear regression analysis, ASD size, sPAP, RV‐RA diameter were found to be significantly associated with increased ALBI score.ConclusionThe ALBI score offers a simple, evidence‐based, objective, and discriminatory method of assessing liver function in patients with ASD. ASD size, sPAP, RV and RA diameters were significantly associated with ALBI score.
The development of a reporting form for peer observation of online learning courses: An e‐Delphi consensus study of educators working in health professions education
Authors: Orsini Cesar , Jennings Barbara , Rodrigues Veena , Tricio Jorge 
Published: March 2023

AbstractIntroductionPeer observation of online teaching has been suggested to maintain and monitor online learning standards. However, this practice and the designed peer observation forms have been almost exclusively restricted to face‐to‐face or stand‐alone synchronous/asynchronous sessions. This study, therefore, aimed to identify criteria for the successful design and delivery of online courses and develop a rigorous form specifically designed for peer observation of teaching in online learning environments applicable to the Health Professions Education context.Materials and MethodsA three‐round e‐Delphi technique was used to gather consensus on categories/items and process/structure of the peer observation form. A total of 21 international, experienced online educators working in Health Professions Education were recruited. A 75% consensus was considered as the minimum agreement level.ResultsResponse rates were 100% (n = 21), 81% (n = 17) and 90% (n = 19) respectively. The intensity of consensus was 38%–93%, while the agreement/disagreement consensus was 57%–100%. In Round 1, the 13 topics proposed as major categories for design and delivery reached agreement consensus. One option reached agreement on how to approach and structure the peer‐observation process. All items within major categories reached agreement in Rounds 2 and 3. The resulting form presents 13 major categories with 81 items.ConclusionThe identified criteria and developed form address relevant educational principles such as constructive alignment, online instructional design, retrieval practice and spaced learning, cognitive load, and constructive feedback and authentic assessment, all of which have been suggested as critical aspects to ensure a high‐quality learning experience. This adds to the literature and to educational practice as clear, evidence‐based guidance for the design and delivery of online courses, which differ distinctly from traditional face‐to‐face teaching. The developed form expands the options for peer observation, from face‐to‐face and stand‐alone synchronous/asynchronous sessions to fully online courses.
Burden of suspected epileptic seizures on emergency services: A population‐based study
Authors: Kämppi Leena , Puolakka Tuukka , Ritvanen Jaakko , Tuppurainen Kati , Päkkilä Jari , Kuisma Markku , Peltola Jukka 
Published: March 2023

AbstractBackground and purposePatients with acute epileptic seizures form a large patient group in emergency neurology. This study aims to determine the burden caused by suspected epileptic seizures at different steps in emergency care.MethodsA retrospective, cross‐sectional, population‐based (>1,000,000 inhabitants), 4‐year (2015–2018) study was conducted in an urban setting with a single dispatch centre, a university hospital‐affiliated emergency medical service (EMS), and five emergency departments (EDs). The study covered all adult (≥16 years old) emergency neurology patients receiving medical attention due to suspected epileptic seizures from the EMS and EDs and during hospital admissions in the Helsinki metropolitan area.ResultsEpileptic seizures were suspected in 14,364 EMS calls, corresponding to 3.3% of all EMS calls during the study period. 9,112 (63.4%) cases were transported to hospital due to suspected epileptic seizures, and 3368 (23.4%) were discharged on the scene. 6969 individual patients had 11,493 seizure‐related ED visits, accounting for 3.1% of neurology‐ and internal medicine‐related ED visits and 4607 hospital admissions were needed with 3 days’ median length of stay (IQR=4, Range 1‐138). Male predominance was noticeable at all stages (EMS 64.7%, EDs 60.1%, hospital admissions 56.2%). The overall incidence was 333/100,000 inhabitants/year for seizure‐related EMS calls, 266/100,000 inhabitants/year for ED visits and 107/100,000 inhabitants/year for hospital admissions. Total estimated costs were 6.8 million €/year, corresponding to 0.5% of all specialized healthcare costs in the study area.ConclusionsPatients with suspected epileptic seizures cause a significant burden on the health care system. Present‐day epidemiological data are paramount when planning resource allocation in emergency services.
Influence of chrysin on D‐galactose induced‐aging in mice: Up regulation of AMP kinase/liver kinase B1/peroxisome proliferator‐activated receptor‐γ coactivator 1‐α signaling pathway
Authors: Salama Abeer , Elgohary Rania 
Published: March 2023

AbstractAdenosine monophosphate kinase/liver kinase B1/peroxisome proliferator‐activated receptor‐γ coactivator 1‐α (AMPK/LKB1/PGC1α) pathway has a vital role in regulating age‐related diseases. It controls neurogenesis, cell proliferation, axon outgrowth, and cellular energy homeostasis. AMPK pathway also regulates mitochondrial synthesis. The current study evaluated the effect of chrysin on D‐galactose (D‐gal) induced‐aging, neuron degeneration, mitochondrial dysfunction, oxidative stress, and neuroinflammation in mice. The mice were allocated randomly into four groups (10 each group): Group 1: normal control group, Group 2: D‐gal group, Groups 3 and 4: chrysin (125 and 250 mg/kg, respectively). Groups 2–4 were injected with D‐gal (200 mg/kg/day; s.c) for 8 weeks to induce aging. Groups 3 and 4 were orally gavaged every day concurrent with D‐gal. At the end of experiment, behavioral, brain biochemical and histopathological changes were monitored. Chrysin administration elevated discrimination ratio in object recognition, Y Maze percentage alternation, locomotor activity and brain contents of AMPK, LKB1, PGC1α, NAD (P)H quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO‐1), nerve growth factor (NGF) (neurotrophin‐3; NT‐3), and seretonin as well as reduced brain contents of tumor necrosis factor‐alpha (TNF‐α), nuclear factor kappa B (NF‐κB), advanced glycation end products (AGEs) and glial fibrillary acidic protein (GFAP) compared to D‐gal‐treated mice. Chrysin also alleviated cerebral cortex and white matter neurons degeneration. Chrysin protects against neurodegeneration, improves mitochondrial autophagy and biogenesis as well as activates antioxidant genes expression. In addition, chrysin ameliorates neuroinflammation and stimulates the release of NGF and serotonin neurotransmitter. So, chrysin has a neuroprotective effect in D‐gal induced‐aging in mice.
Novel role for linear ubiquitination in regulating NFAT1 stability
Authors: De Meyer Femke , Afonina Inna S. 
Published: March 2023

Linear ubiquitination is an important post‐translational modification regulating the activation of numerous proinflammatory signalling mediators. Deregulated linear ubiquitination has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. In this issue, Miao et al. have identified a novel role for linear ubiquitination in the stabilisation of the NFAT1 transcription factor, leading to enhanced NFAT1‐mediated gene expression, which might have functional implications in patients with Kawasaki disease.
Advanced practice nursing initiatives in Africa, moving towards the nurse practitioner role: Experiences from the field
Authors: Gray Deborah C. , Rogers Melanie , Miller Minna K. 
Published: March 2023

AbstractAimThis paper discusses the development and progression of the advanced practice nurse practitioner role in Africa.BackgroundProviding adequate primary health care is problematic in Africa. The World Health Organization and International Council of Nurses proposed that nurses, specifically advanced practice nurse practitioners with the requisite skills in disease prevention, diagnosis and management, can be key to solving the primary care issue.Sources of evidenceThis paper utilized publications from PUBMED, CINAHL, policy papers, websites, workgroups, conferences, and the experiences and knowledge of authors involved in leading and moving forward key events and projects.DiscussionFour African countries have formally adopted the advanced practice nurse practitioner role, with significant interest from countries throughout Africa, and ever‐increasing requests for assistance regarding initiation, development and integration of advanced practice roles. Initiatives to advance the roles have been supported by the International Council of Nurses Nurse Practitioner/Advanced Practice Nurse Network and Global Academy of Research and Enterprise. Next steps and projects for future role development are discussed.ConclusionsThere is a progression towards the adoption of the advanced practice nurse practitioner role in Africa, and further mechanisms are suggested to allow full uptake and utilization.Implications for nursing practicePrioritization and investment in initiatives implementing nurse practitioner/advanced practice nurse roles in Africa allows nurses to pursue further education, advanced role and leadership opportunities consistent with Nursing Now goals.Implications for health policyImplementation of nurse practitioner/advanced practice nurse roles increases the primary care workforce, consistent with recommendations and priorities in the World Health Organization Global Strategic Directions for Nursing and Midwifery 2021–2025 helping countries ensure that nurses optimally contribute to achieving universal health coverage and other population health goals.
Die anatomischen Grundlagen für den Wassertransport im Primärxylem von Ginkgo biloba L
Authors: Eicke R. 
Published: March 2023

ZusammenfassungDurch ultradünne Quer‐ und Längsschnitte sind die anatomischen Grundlagen für den Wasserdurchfluß im Primärxylem festgestellt worden. Ergebnisse:
. Die Spiraltracheiden haben dünne Wände (60 nm), die nur mit Hilfe der elektronenmikroskopischen Vergrößerungen gemessen werden können. Da die Spiralbänder oft nur mit schmaler Basis (weniger als ein Drittel ihrer Breite) der Wand aufliegen, bleiben große dünne Flächen zum allseitigen Durchfluß des Wassers frei.
. Das Primärxylem enthält neben Spiraltracheiden Netz‐ und Tüpfeltracheiden und Mischungen dieser Typen, wobei die Dünnstellen der Nachbarzellen oft nicht korrespondieren und somit funktionslos sind.
Die Vegetation des Cerro San Fernando und des Cerro La Llorona im Trockengebiet bei Santa Marta, Kolumbien
Authors: Schnetter R. 
Published: March 2023

ZusammenfassungIm Bereich der Erhebungen Cerro San Fernando und Cerro La Llorona im Trockengebiet bei Santa Marta, Kolumbien (0 bis 370 m Höhe ü. M., etwa 600 mm mittlere jährliche Niederschläge, 27 bis 29°C Jahresmitteltemperaturen), kommen an den für den Pflanzenwuchs günstigsten Stellen 12 bis 15 m hohe regengrüne Trockenwälder vor. Auf zunehmend trockneren Standorten wachsen dort Dorngehölze, Kakteendorngehölze (stellenweise mit Agaven) und eine halbwüstenartige Kleinstrauchvegetation. Die Artenzusammensetzung und räumliche Verteilung der einzelnen Pflanzengesellschaften (Vegetationskarte) in Abhängigkeit von bestimmten Eigenschaften des Bodens und des Mikroklimas sowie anthropogener Einwirkungen werden dargestellt.
Restitution der Kernmembran in postmeiotischen Basidien
Authors: Thielke Charlotte 
Published: March 2023

ZusammenfassungDie Membranen der postmeiotischen Kerne entstehen als Differenzierungen eines endoplasmatischen Retikulums, das einerseits mit wandständigem ER in Verbindung steht und andererseits räumliche Beziehungen zu einem Körper zeigt, der in seiner peripheren Lage den Eindruck eines „Organisators” macht und vielleicht mit dem Centriol identisch ist.Der Deutschen Forschungsgemeinschaft danke ich für Sachbeihilfe.
Über reniforme Gefäßdurchbrechungen im Holz einiger Kakteen1)
Authors: Süss Herbert 
Published: March 2023

ZusammenfassungIn den Gefäßen einiger Kakteenarten, die in stärkerem Maß Holz bilden, wurden Durchbrechungen gefunden, die wir reniform (= nierenförmig) nennen; sie treten stets in Verbindung mit normalen, einfachen Durchbrechungen auf. Reniforme Durchbrechungen entstehen offensichtlich durch schrittweise Fusion einzelner lochförmiger Durchbohrungen, die sich um einen in der Mitte der Perforationsfläche befindlichen Rest der Gefäßquerwand gruppieren.