bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quiet quitting among nurses increases their turnover intention: Evidence from Greece in the post-COVID-19 era
Authors: Galanis Petros , Moisoglou Ioannis , Katsiroumpa Aglaia , Vraka Irene , Siskou Olga , Konstantakopoulou Olympia , Kaitelidou Daphne 
Published: August 2023

Abstract
Background
As turnover intention is a strong determinant of actual turnover behavior, scholars should identify determinants of turnover intention.
Purpose
To assess the effect of quiet quitting on nurses’ turnover intention. Additionally, we investigated the impact of several demographic and job characteristics on turnover intention.
Methods
A cross-sectional study with 629 nurses in Greece was conducted. Data collected during June 2023. We measured quiet quitting with the “Quiet Quitting” scale.
Findings:
In our sample, 60.9% of nurses were considered as quiet quitters, while 40.9% experienced high levels of turnover intention. Multivariable regression analysis showed a positive relationship between quiet quitting and turnover intention. Moreover, we found that turnover intention was higher among females, shift workers, nurses in the private sector, and those that they considered their workplace as understaffed. Also, we found a positive relationship between clinical experience and turnover intention.
Conclusions
Since quiet quitting affects turnover intention, organizations, policy makers and managers should address this issue to improve nurses’ intention to stay at their works.
Numerical Method on the Generalized Gamma Distribution Parameters Using Picard’s Method
Authors: Maswadah M. 
Published: August 2023

AbstractRecently, in the literature, many modifications have been introduced to improve the maximum likelihood estimation method. However, most of them are less efficient than the Bayes’ method, especially for small samples. Therefore, in this study, a numerical method based on Picard’s method has been introduced for estimating the generalized gamma distribution parameters and comparing them with Bayes’ method based on the informative gamma and kernel priors. A comparison between these estimates is provided by an extensive Monte Carlo simulation study based on two criteria: absolute bias and mean squared error. The simulation results indicated that Picard’s method is highly favourable, which provides better estimates and outperforms the Bayes’ method using different loss functions based on the generalized progressive hybrid censoring scheme. Finally, two real dataset analyses for the COVID-19 epidemic in Egypt are presented to illustrate the efficiency of the proposed methods.
Cardiac-Specific Gene TNNI3 Acts as a Potential Oncogene for Papillary Renal Cell Carcinoma
Authors: Cai Biao , Chen Xiaoxiang , Yang Lu , Huang Wenqi , Zhao Weian 
Published: August 2023

Abstract
Background
The TNNI3 gene, responsible for encoding the inhibitory subunit of the troponin complex known as cardiac troponin I (cTnI), has significant implications in cardiology research. Despite reports of its abnormal expression in human carcinoma cells, the precise functions of TNNI3 in cancer remain largely unexplored. The present study seeks to examine the prognostic significance of TNNI3 in papillary renal cell carcinoma (pRCC).
Methods
The mRNA expression profiles were acquired from the Cancer Genome Atlas (TCGA) database to identify candidate prognostic genes using univariate Cox analysis, log-rank test, and the least absolute shrinkage and selection operator (LASSO) analysis. A prognostic risk formula was established through multivariable Cox regression analysis. Additionally, Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and immune-related function analyses were conducted. Furthermore, western blot, cell proliferation assay, and wound healing assay were employed to validate the in vitro biological effects of TNNI3.
Results
A total of 361 differentially expressed genes (DEgenes) were found to be correlated with TNNI3 expression. A prognostic risk formula including the genes PTPRH, LGR5, and DMRT3 was then formulated. Notably, the low-risk group demonstrated superior overall survival (OS) outcomes compared to the high-risk group, as observed in both the training and validation cohorts. To further elucidate the potential functions of these three genes, a target gene network was constructed. Subsequent GO and KEGG analyses revealed their involvement in the Wnt signaling pathway, which was confirmed through western blot experiment. Furthermore, cellular experiments demonstrated that TNNI3 promotes the proliferation and metastasis of pRCC cells. Lastly, immune analyses indicated that increased expression of TNNI3 in pRCC is associated with a poorer response to immunotherapy.
Conclusion
TNNI3 might function as an oncogene via activating Wnt signaling pathway in pRCC and a three-gene signature related to TNNI3 could serve as a prognostic biomarker for pRCC. Insights are indeed provided into the potential oncogenic functions of TNNI3 in cancer research.
Irritable bowel syndrome and IBS-like syndrome: current concepts, diagnosis, treatment approaches
Authors: Minushkin O. N. 
Published: August 2023

The article presents the latest international guidelines on functional gastrointestinal disorders (Rome IV criteria). It is difficult to consider all functional disorders within one paper, and therefore it was decided to address the problem using the example of the most common functional disorder – irritable bowel syndrome (IBS) and a similar IBS-like syndrome (IBS-LS), which is particularly problematic in clinical practice. The case is illustrated by our own findings i.e. an analysis of 130 patients (80 with IBS and 50 with IBS-LS). The treatment included a specialized probiotic ProbioLog IBS (1 capsule per day) and involved several steps (each step comprises 2 weeks, 6 weeks in total). At the end of each treatment step, the therapy was evaluated followed by correction of the following step. The effectiveness of treatment was 80%; additional correction was required for 10% of patients with persistent pain, which was relieved by adding Meteospasmil to the treatment combination. Administration of digestive enzymes was required for 10% of patients with IBS-PS, which developed due to chronic pancreatitis at the stage of exocrine pancreatic insufficiency. Thus, the therapeutic effect on altered microbiota, one component of the pathological symptom group (IBS and IBS-LS), with a probiotic containing three bacterial strains targeted in IBS (ProbioLog IBS) was effective in 80% of patients, and only 20% needed additional correction of treatment with motility regulators and enzyme drugs.
Coenzyme Q: food sources, adequate and clinically effective doses
Authors: Kodentsova V. M. , Risnik D. V. , Sarkisyan V. A. , Frolova Yu. V. 
Published: August 2023

Coenzyme Q (CoQ) plays a key role in cell bioenergetics; it is not only supplied with food, but also synthesized in the body. Endogenous CoQ synthesis decreases with age, with statin use, with cardiovascular, neurodegenerative, and other diseases. In this regard, specialized food products (SFP) enriched with CoQ are being developed. Aim of the review – compare the CoQ doses allowed for use as part of dietary supplements and SFP with doses that provide a clinical effect. Literature review was carried out using the RSCI, Pubmed databases and Google Scholar, ReserchGate systems for the keywords “ubiquinone”, “coenzyme Q10”. The amount of CoQ contained in SFP is set by domestic regulatory documents based on an adequate daily intake for adults (30 mg) and the upper allowable intake level as part of SFP and dietary supplements – 100 mg/day. Actually used doses of CoQ range from 60 to 500 mg/day. Various ways to increase the bioavailability of CoQ have been described. When patients take CoQ, a U-shaped dose-effect relationship is observed, an effective dose that significantly reduces systolic blood pressure, fasting glucose and insulin levels, the degree of hemoglobin glycation, the HOMA-IR glycemic test is in the range of 100–200 mg / day. An improvement in the antioxidant status and a decrease of pro-inflammatory cytokines concentration in the blood plasma of athletes is provided by CoQ doses of 60–300 mg/day, in patients with type 2 diabetes mellitus and coronary heart disease, doses of 100–150 mg/day. Clinically effective doses of CoQ (100–200 mg/day) when used for at least 12 weeks correspond to or are 1.5–2 times higher than the upper allowable consumption level in the composition of SFP and dietary supplements. The inclusion of CoQ in the dietary therapeutic SFP in an amount that does not reach doses that are effective in a certain pathology does not achieve the expected result. A possible way to solve the problem is to increase the acceptable levels of consumption of CoQ in SFP, as well as increasing the bioavailability of CoQ in the composition of emulsions, liposomes, phytosomes and oleogels.
Features of the course of pregnancy and health of newborns with intrauterine growth restriction
Authors: Volochaeva M. V. , Kan N. E. , Tyutyunnik V. L. , Gasymova Sh. R. , Borisova A. G. 
Published: August 2023

Introduction. The development of intrauterine growth restriction (IUGR) begins with fertilization and trophoblast invasion. IUGR is manifested in a decrease in fetal growth rate. However, data on risk factors for fetal growth retardation, their combination with various chronic diseases in a pregnant woman are contradictory.Objective. To study the features of the course of pregnancy, childbirth, the health status of newborns with IUGR. Materials and methods. The study was a retrospective cohort study. At the first stage, we analyzed 1574 birth histories with a diagnosis of IUGR, placental insufficiency, women with normal pregnancy who gave birth (2016–2021). According to the inclusion and exclusion criteria, 408 women were included in the study. The women were divided into 2 groups. The first group included 202 pregnant women with a diagnosis of IUGR. In the second Group – 206 pregnant women with normal pregnancy, without IUGR, delivered at the time corresponding to the terms in the main group.Results. We have clarified the risk factors and premorbid conditions involved in the development of IUGR (somatic and gynecological morbidity, pregnancy course). Their analysis is necessary to predict IUGR. The analysis of the timing and method of delivery in the studied groups was carried out. A higher incidence of complications in the early neonatal period was revealed when assessing the health status of newborns with IUGR.Conclusion. Thus, the study of the mechanisms of IUGR formation in the future will allow the development of modern pathogenetic approaches to prevention and treatment.
MRI signs of mental disorders
Authors: Ageeva S. F. 
Published: August 2023

Radiology methods were believed to be used to assess only structural changes in the brain. Therefore, for a long time, their use in psychiatry was seen ineffective. However, the subsequent development and emergence of new visualization techniques led to the appearance of previously inaccessible opportunities. In modern psychiatric practice magnetic resonance imaging (MRI), taskbased functional MRI (fMRI) and resting state fMRI are methods of the greatest interest. Both structural and functional changes of brain can be assessed with these techniques. Using MRI with high spatial resolution, it’s possible to assess changes in the gray matter of the brain, including its regional volume, cortical thickness, shape of the convolutions and subcortical structures. With the use of fMRI it became possible to evaluate neural activity and neural circuits of the brain. In task-based fMRI patient complete certain tasks, which leads to an increase in blood supply and oxygenation of activated parts of the brain. Resting MRI, on the other hand, evaluates spontaneous fluctuations in the brain activity. Although the diagnosis of mental illness is not based on MRI alone, imaging techniques can facilitate the process. MR-signs such as hypo- or hyperactivation of brain areas, an increase or decrease in the volume of brain zones can be observed. The text describes examples of MR-characteristics of attention deficit hyperactivity disorder, bipolar disorder, major depressive disorder, schizophrenia, and MR-features of cognitive impairment in multiple sclerosis.
Epidemiological analysis of systemic mycoses in COVID-19
Authors: Martynova A. V. , Pavlova O. S. , Yusupova E. P. 
Published: August 2023

Introduction. When analyzing constantly incoming information, it becomes clear that the growing risk of co-infections with a new coronavirus infection is the main threat of complications leading to death.Aim. A significant part of the information is the data accumulated by specialists on co-infections with systemic mycoses, which often causes a fatal outcome in coronavirus infection.Material and methods. In study systematized information about systemic mycoses in case of coronavirus infection, diagnosed according to the data of medical institutions in Vladivostok, specializing in the treatment of patients with a new coronavirus infection in the period from autumn 2020 to spring 2021.The results of a survey of 200 patients with a new coronavirus infection who were diagnosed with ventilator-associated pneumonia were studied.Results and discussion. Systemic mycoses in patients with COVID-19 do not create a relatively new situation: fungal-bacterial or viral-fungal co-infections were described even during the H1N1 or H7N9 influenza outbreaks. Almost all patients were treated with corticosteroids at high doses causing immunosuppression, which in turn contributed to the development of systemic mycosis. 26% (52 patients) were diagnosed with systemic mycoses, where the leading pathogens were fungi of the genus Aspergillus: A. niger, A terreus, A. fumigatus. The second place (15%, 30 patients) was occupied by representatives of the genus Candida, where C. albicans prevailed. All patients with diagnosed mycoses who were on treatment were prescribed, among other things, antimycotic therapy (voriconazole, fluconazole, caspofungin). However, all patients had a lethal outcome, which was determined by the combination of infection with the SARS-CoV-2 virus, and, ultimately, by the development of systemic mycosis, including the presence of concomitant pathology that determines the development of the infectious process.Conclusions. In the event of novel coronavirus infection, identification of associations of SARS-CoV-19 virus and other viruses combined with fungi also requires early clinical evaluation.
Prospects for the application of bacteriophages in the treatment of sinusitis caused by antibiotic-resistant bacterial strains
Authors: Kryukov A. I. , Gurov A. V. , Cherkasov D. S. , Teplykh E. A. 
Published: August 2023

Purulent diseases in otorhinolaryngology are of great interest due to their widespread prevalence and the objective difficulties of treatment. One of the most frequently encountered nosological forms is purulent sinusitis. A key element in the complex treatment of bacterial sinusitis is systemic antibiotic therapy aimed at the eradication of pathobionts from the focus of infection. However, the increasing worldwide drug resistance of etiologically significant microorganisms complicates antibacterial chemotherapy of purulent sinusitis and raises questions about its future feasibility. The threat of a change from a resistance era to a post-antibiotic era is very significant, given the acute shortage of new antibiotics and the relatively rapid adaptation of bacterial microorganisms to them. The global community is therefore faced with the challenge of finding other drugs with antimicrobial activity. In recent decades, genetically modified virulent bacteriophages and phagolytes isolated on their basis are becoming increasingly attractive in the fight against purulent infections of various localizations caused by drug-resistant bacteria. This literature review focuses on the potential of phage therapy for acute bacterial sinusitis in an era of globally increasing bacterial strain resistance. The article details the causative agents of community-acquired and hospital-acquired acute sinusitis, the main mechanisms of bacterial antibiotic resistance, the effect of virulent phages on bacteria, and studies on the efficacy of phage therapy in the treatment of acute sinusitis. The facts outlined herein clearly indicate the efficacy of phage therapy, as well as therapeutic perspectives on using bacteriophages in the complex treatment of purulent sinusitis caused by antibiotic-resistant microbiota.
Features of the course of diffuse toxic goiter in elderly patients
Authors: Bulgakova S. V. , Kosareva O. V. , Dolgikh Yu. A. , Sharonova L. A. , Treneva E. V. , Kurmayev D. P. 
Published: August 2023

Diffuse toxic goiter is one of the frequent endocrine pathologies that lead to damage to the cardiovascular system. The prevalence of thyrotoxicosis in people over 65 years of age is 15%. The clinic of thyrotoxicosis among elderly patients is nonspecific and asymptomatic. Asthenic symptoms prevail – increasing muscle weakness, weight loss, neurological symptoms, expressed in lethargy and depression, changes in the gastrointestinal tract, cardiovascular system. Elderly patients often have tachycardia, atrial fibrillation, atrial fibrillation, increasing heart failure, which is associated with age-related changes in the myocardium, concomitant atherosclerosis-associated diseases. Atrial fibrillation in patients with thyrotoxicosis increases the risk of thromboembolic complications. Low-symptomatic manifestations of thyrotoxicosis require a more thorough examination, including laboratory, hormonal and instrumental methods. This article considers a clinical case of an elderly patient with diffuse toxic goiter. The features of the clinical picture with the predominance of disorders from the cardiovascular system -interruptions in the work of the heart, increased shortness of breath, signs of increasing cardiovascular insufficiency are presented. Diagnostic studies, differential diagnostic search, confirming the presence of thyrotoxicosis and cardiovascular insufficiency were conducted. Appropriate treatment has been prescribed. An integrated approach in the treatment of patients with diffuse toxic goiter in combination with ischemic heart disease significantly improves the condition of patients, normalizes the thyrotoxic status, and, consequently, the state of the cardiovascular system against the background of the use of thyrostatics. Also, the wellbeing of patients improves because of correction of cardioprotective therapy, the heart rate is normalized, the signs of chronic heart failure are significantly compensated.
ADHERENCE TO THERAPEUTIC EXERCISE IN PATIENTS WITH NONSPECIFIC LOW BACK PAIN
Authors: LONČARİĆ KELEČİĆ Iva , SCHUSTER Snježana 
Published: August 2023

Purpose: Adherence to therapeutic exercises for low back pain can significantly impact longevity, quality of life, and health care costs. There is insufficient research describing the nature and relationship between specific patient characteristics and exercise adherence in non-specific low back pain (NSLBP). This research aimed to examine: (i) the relationship between education and adherence, (ii) the relationship between perceived pain level and adherence, and (iii) whether education and pain level are significant predictors of adherence.
Methods: Observational analytic research was conducted in a physiotherapy outpatient setting on a sample of 50 subjects with NSLBP. Data collected were: sociodemographic, pain level according to the visual analogue scale (VAS) and adherence measured by the Exercise Adherence Rating Scale (EARS). For hypotheses testing, statistical methods used were; t-test for small independent samples (i), Pearson correlation coefficient (ii) and linear regression analysis (iii).
Results: The results show that: (i) people with a college education are more adherent, (ii) increasing adherence reduces pain level, and (iii) education and pain level are significant in predicting adherence, where education is a stronger predictor.
Conclusion: College-educated persons are more prone to therapeutic exercise, and adherence determines physiotherapy outcomes. The contribution of research to clinical practice is reflected in the findings of the nature and relationship between education level and exercise adherence in NSLBP and its significant impact on physiotherapy outcomes.
Estimating discharge coefficient of triangular free overfall using the GMDH technique
Authors: Mohammed Ahmed Y. , Sharifi Ali 
Published: August 2023

Abstract
Free overfalls are hydraulic structures used in flood control, water supply, irrigation, and flow measurements. The hydraulic systems of free overfall depend on rectangular end shape. The studies that dealt with triangular crest are few and almost non-existent. In this study, a triangular end-shape design uses multiple linear regression (MLR) and group method of data handling (GMDH) methods for four models with six sub-models. Then, 24 scenarios were chosen and compared. The discharge coefficient (Cd) of a free overfall with a triangular terminal was predicted using experimental data. The triangular end edge shape increased crest length, the discharge coefficient, and discharge passing over free overfall. To this goal, 180 triangular free fall tests were performed. Data were collected for two triangular free overfalls with an opposite flow direction with three angles 600, 750, and 900. Results of Cd acquired using the two ways discussed above show that the algorithm GMDH outperforms the other method. Values for the GMDH approach mod46 testing variables: RMSE, MARE, SI, R2, and NSE are 6.08 × 10−17, 2.65 × 10−17, 6.00 × 10−17, 100.00%, and 1.00, respectively, while these values for MLR are 0.06332, 0.05970, 0.06624, 15.431%, and −3.0419, respectively. The GMDH technique shows the best results concerning MLR and then chooses the best four scenarios from 24 with a Cd percentage error not exceeding ±2%.
Spatial variation of dissolved organic matter in the Tuojiang River Basin in Chengdu, China: insights based on EEMs–PARAFAC analysis
Authors: Li Xiaxia , Chai Beibei , Wang Chao , Li Hongtao , Wu Yong , Lei Xiaohui , Chen Bin 
Published: August 2023

Abstract

Three-dimensional excitation–emission matrix fluorescence spectroscopy coupled with parallel factor analysis was adopted to investigate the characteristics of dissolved organic matter (DOM) components in water samples collected from the Tuojiang River Basin in Chengdu, including its main stream and tributaries. Four DOM components that matched with three fluorescence peaks were identified in the whole river basin and tributaries; while three components corresponding to four fluorescence peaks were identified in the main stream. In all cases, humic-like components accounted for high proportions of the DOM. Correlation analysis revealed the same sources for four components in the whole river basin and its tributaries, whereas two components had different sources in the main stream. Ultraviolet absorbance parameters (SUVA254, SR) and fluorescence parameters (BIX, HIX, FI, β:α) indicated the dominant autochthonous sources of DOM in the whole river basin. Higher terrestrial inputs of DOM were observed in the tributaries than in the main stream. In the areas influenced by human activities (6#, 17#, 18#), the sources of DOM showed strong terrestrial characteristics and high degrees of humification and aromatization, as well as serious pollution. The results of this study have potentially far-reaching implications for environmental water management in the area.