bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes after cardiac rehabilitation in patients following repair of thoracic aortic aneurysm or dissection: a protocol for a systematic review and meta-analysis
Authors: Koenders Niek , van Zetten Henrita , Smulders Michelle , Verra Martin L. , van Kimmenade Roland R. J. , van Brakel Thomas , Eijsvogels Thijs M. H. , Smith Tim 
Published: February 2023

Abstract
Background
Patients receiving thoracic aortic repair suffer from long-term impairment in daily functioning and quality of life following intervention due to a combination of their life-threatening condition (i.e. aortic aneurysm or dissection), undergoing major surgery, as well as long-term exercise restrictions thereafter. Despite the known risks of exercise, it is vital that patients regain physical activity in order to recover their daily functioning and quality of life. Cardiac rehabilitation could be a safe and effective treatment to support patients to become physically active by providing exercise training, comprehensive rehabilitation services, and safety recommendations. Despite new insights in recent literature and clinical practice, international guidelines do not recommend cardiac rehabilitation due to limited evidence. We aim to fill this knowledge gap by performing a systematic review and meta-analysis on the effectiveness of cardiac rehabilitation in patients following thoracic aortic repair.

Methods
This protocol has been developed following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). MEDLINE, Embase, and CINAHL will be searched for eligible observational and interventional studies from inception up to April 2022. Screening (title/abstract and full text), data extraction, risk of bias assessment, and therapeutic validity rating will be conducted by two independent reviewers. A random-effects model will be used to meta-analyse performance-based outcomes, patient-reported outcomes, clinician-reported outcomes, and researcher-reported outcomes. Subsequently, meta-bias and confidence in evidence will be analysed by two independent reviewers.

Discussion
To exercise or not to exercise in patients following thoracic aortic repair has been a topic of discussion for years. The intended systematic review and meta-analysis will provide comprehensive evidence on the effectiveness of phase III outpatient exercise-based cardiac rehabilitation in patients following thoracic aortic repair. Findings from this review may inform future guidelines for the management of patients with thoracic aortic disease.

Systematic review registration
PROSPERO CRD42022301204.
Impacts of small-scale irrigation water use on environmental flow of ungauged rivers in Africa
Authors: Geleta Yohannes , Simane Belay , Assefa Engdawork , Haileslassie Amare 
Published: February 2023

AbstractFailure in Environmental flow in quantity, timing, and quality leads to failure to support ecosystems, human livelihoods, and well-being. Irrigation water use is one of the main actors in impacting the water flow of rivers in quantity and time but was not well investigated in many ungauged catchments under smallholder irrigation systems. This study examined the impact of irrigation water use on environmental flow in Arata's small ungauged catchment. The study estimated the flow in sub-catchment using the area ratio method, the crop irrigation water requirement using F.A.O. cropwat 8.0, and the water balance in the Water Evaluation and Planning System tool and the environmental flow in Tennants, Q95, asnd local area thumb rule. The result showed that the minimum environmental flow of the Arata catchment is 290, 310, and 60 li/sec in the Tennant, Q95, and the local thumb rule. Irrigation consumes only 9% of the water resources of the catchment while 91% is contributed to downstream lake Ziway via Ketar river. January and February have unmet water demand and zero environmental flow. In December Tennant's 10% and Q95 recommended environmental flow had 19% and 24% deficit while the thumb rule environmental flow is 291% more than the minimum requirement. The rest of the months are by far more than the minimum environmental flow requirement. Given the result, meeting the environmental flow of the system throughout the year needs the installation of a water storage facility from upstream to downstream, the introduction of different water-saving irrigation technologies, farmers' capacity building in irrigation water management, and a standardized environmental flow estimation mechanism.
Coping with COVID in corrections: a qualitative study among the recently incarcerated on infection control and the acceptability of wastewater-based surveillance
Authors: Riback Lindsey R. , Dickson Peter , Ralph Keyanna , Saber Lindsay B. , Devine Rachel , Pett Lindsay A. , Clausen Alyssa J. , Pluznik Jacob A. , Bowden Chava J. , Sarrett Jennifer C. , Wurcel Alysse G. , Phillips Victoria L. , Spaulding Anne C. , Akiyama Matthew J. 
Published: February 2023

Abstract
Background
Correctional settings are hotspots for SARS-CoV-2 transmission. Social and biological risk factors contribute to higher rates of COVID-19 morbidity and mortality among justice-involved individuals. Rapidly identifying new cases in congregate settings is essential to promote proper isolation and quarantine. We sought perspectives of individuals incarcerated during COVID-19 on how to improve carceral infection control and their perspectives on acceptability of wastewater-based surveillance (WBS) accompanying individual testing.

Methods
We conducted semi-structured interviews with 20 adults who self-reported being incarcerated throughout the United States between March 2020 and May 2021. We asked participants about facility enforcement of the Centers for Disease Control and Prevention (CDC) COVID-19 guidelines, and acceptability of integrating WBS into SARS-CoV-2 monitoring strategies at their most recent facility. We used descriptive statistics to characterize the study sample and report on acceptability of WBS. We analyzed qualitative data thematically using an iterative process.

Results
Participants were predominantly Black or multiple races (50%) and men (75%); 46 years old on average. Most received a mask during their most recent incarceration (90%), although only 40% received counseling on proper mask wearing. A quarter of participants were tested for SARS-CoV-2 at intake. Most (70%) believed they were exposed to the virus while incarcerated. Reoccurring themes included (1) Correctional facility environment leading to a sense of insecurity, (2) Perceptions that punitive conditions in correctional settings were exacerbated by the pandemic; (3) Importance of peers as a source of information about mitigation measures; (4) Perceptions that the safety of correctional environments differed from that of the community during the pandemic; and (5) WBS as a logical strategy, with most (68%) believing WBS would work in the last correctional facility they were in, and 79% preferred monitoring SARS-CoV-2 levels through WBS rather than relying on just individual testing.

Conclusion
Participants supported routine WBS to monitor for SARS-CoV-2. Integrating WBS into existing surveillance strategies at correctional facilities may minimize the impact of future COVID-19 outbreaks while conserving already constrained resources. To enhance the perception and reality that correctional systems are maximizing mitigation, future measures might include focusing on closer adherence to CDC recommendations and clarity about disease pathogenesis with residents.
The role of artificial intelligence in the treatment of obstructive sleep apnea
Authors: Brennan Hannah L. , Kirby Simon D. 
Published: February 2023

Background The first-line and most common treatment for obstructive sleep apnea is nasal continuous positive airway pressure, which serves as a pneumatic splint to stabilize the upper airway and is effective when used with appropriate adherence. Continuous positive airway pressure compliance rates remain significantly low despite machine improvements and compliance intervention. Other treatment options include oral appliances, myofunctional therapy, and surgery. The aim of this project is to elucidate the role of artificial intelligence within improving the treatment of obstructive sleep apnea. Methods Related publications between 1999 and 2022 were reviewed from PubMed and Embase databases utilizing search terms “artificial intelligence,” “machine learning,” “obstructive sleep apnea,” and “treatment.” Both authors independently screened the results by title/abstract then by full text review. 126 non-duplicate articles were screened, 38 articles were included after title and abstract screen and 30 articles were included after full text review. The inclusion criteria are outline in the PICO framework and involved studies focused on artificial intelligence application in guiding and evaluating obstructive sleep apnea treatment. Non-English articles were excluded. Results The role of artificial intelligence in the treatment of OSA was categorized into the following sections: Predicting treatment outcomes of various treatment options, Improving/Evaluating treatment, and Personalizing treatment with improving understanding of underlying mechanisms of OSA. Conclusions Artificial intelligence has the capacity to improve the treatment of OSA through predicting outcomes of treatment options, evaluating the treatment the patient is currently utilizing and increasing understanding of the mechanisms that contribute to OSA disease process and physiology. Implementing AI in guiding treatment decisions allows patients to connect with treatment methods that would be most effective on an individual basis.
Performance evaluation of deep learning techniques for DoS attacks detection in wireless sensor network
Authors: Salmi Salim , Oughdir Lahcen 
Published: February 2023

AbstractWireless sensor networks (WSNs) are increasingly being used for data monitoring and collection purposes. Typically, they consist of a large number of sensor nodes that are used remotely to collect data about the activities and conditions of a particular area, for example, temperature, pressure, motion. Each sensor node is usually small, inexpensive, and relatively easy to deploy compared to other sensing methods. For this reason, WSNs are used in a wide range of applications and industries. However, WSNs are vulnerable to different kinds of security threats and attacks. This is primarily because they are very limited in resources like power, storage, bandwidth, and processing power that could have been used in developing their defense. To ensure their security, an effective Intrusion detection system (IDS) need to be in place to detect these attacks even under these constraints. Today, traditional IDS are less effective as these malicious attacks are becoming more intelligent, frequent, and complex. Denial of service (DOS) attack is one of the main types of attacks that threaten WSNs. For this reason, we review related works that focus on detecting DoS attacks in WSN. In addition, we developed and implemented several Deep learning (DL) based IDS. These systems were trained on a specialized dataset for WSNs called WSN-DS in detecting four types of DoS attacks that affects WSNs. They include the Blackhole, Grayhole, Flooding, and Scheduling attacks. Finally, we evaluated and compared the results and we discuss possible future works.
Market capitalization shock effects on open innovation models in e-commerce: golden cut q-rung orthopair fuzzy multicriteria decision-making analysis
Authors: Moiseev Nikita , Mikhaylov Alexey , Dinçer Hasan , Yüksel Serhat 
Published: February 2023

AbstractThis research paper analyzes revenue trends in e-commerce, a sector with an annual sales volume of more than 340 billion dollars. The article evaluates, despite a scarcity of data, the effects on e-commerce development of the ubiquitous lockdowns and restriction measures introduced by most countries during the pandemic period. The analysis covers monthly data from January 1996 to February 2021. The research paper analyzes relative changes in the original time series through the autocorrelation function. The objects of this analysis are Amazon and Alibaba, as they are benchmarks in the e-commerce industry. This paper tests the shock effect on the e-commerce companies Alibaba in China and Amazon in the USA, concluding that it is weaker for companies with small market capitalizations. As a result, the effect on estimated e-trade volume in the USA was approximately 35% in 2020. Another evaluation considers fuzzy decision-making methodology. For this purpose, balanced scorecard-based open financial innovation models for the e-commerce industry are weighted with multistepwise weight assessment ratio analysis based on q-rung orthopair fuzzy sets and the golden cut. Within this framework, a detailed analysis of competitors should be made. The paper proves that this situation positively affects the development of successful financial innovation models for the e-commerce industry. Therefore, it may be possible to attract greater attention from e-commerce companies for these financial innovation products.
Enlarging aneurysm sac post EVAR – type V or occult type II Endoleak?
Authors: Patel Shyamal , Chun Joo-Young , Morgan Robert 
Published: February 2023

Abstract
Purpose
Several theories exist regarding the underlying mechanism of type V endoleaks (T5EL), which remains unclear. Torikai et al. (2018) describe sac expansion in cases with patchy heterogenous enhancement of peripheral thrombus and postulate these are due to atypical type II endoleaks (T2EL) from proliferated vasa vasora. These cases of apparent endotension pose a therapeutic challenge as continued sac expansion warrants active intervention.

Materials and methods
Retrospective review of T5EL cases was performed who underwent multidisciplinary discussion at our institution between 2020–2021. Clinical history and imaging were reviewed by a vascular interventional radiologist aiming to identify the underlying mechanism of sac expansion.

Results
Two cases of these specific T5ELs were identified. One patient underwent endovascular management and image-guided aspiration of intra-sac fluid whilst another underwent open surgical ligation and sac plication. In both cases, fluid re-accumulated with re-expansion of the aneurysmal sac on follow-up. Careful review of CT imaging showed subtle foci of peripheral sac enhancement, suggestive of vasa vasora causing occult T2ELs. This was not visible on single phase CTA, super-selective angiography or cone beam CT.

Conclusion
We identified two complex cases with unexplained sac expansion following EVAR suggestive of T2ELs from proliferated vasa vasora. Transcatheter embolisation of this network of vessels although challenging has been previously considered to stunt sac expansion. We suggest this phenomenon is under-diagnosed. Nevertheless, long-term surveillance is warranted as continued sac expansion risks changes in aneurysm morphology leading to potential loss of the proximal/distal seal zones.
Measurement of Δ9THC and metabolites in the brain and peripheral tissues after intranasal instillation of a nanoformulation
Authors: Upadhyay Gunjan , Fihurka Oksana , Habecker Connor , Patel Pranav , Sanchez-Ramos Juan 
Published: February 2023

AbstractBackgroundComparative bioavailability of cannabinoids following their administration by dosing routes has been studied previously, but there are no quantitative reports of distribution of Δ9THC, nor its metabolites, across various brain regions following intranasal (i.n.) administration. The aim of the present study was to determine the time course of Δ9THC transport from nose to brain and to quantify the distribution of Δ9THC and its metabolites in four brain regions.MethodsΔ9THC was formulated as a lipophilic nano-emulsion and instilled i.n. to three groups of adult mice and euthanized after 2, 4, and 8 h. Brains were dissected into 4 regions. Sensitive analytical methods (HPLC-MS) were utilized to quantify levels of Δ9THC and metabolites in brain regions and peripheral tissues. Data was expressed as mean concentrations (± SEM) of Δ9THC and metabolites in brain regions, blood, plasma, urine, and liver. Two-way analysis of variance was performed followed by post hoc multiple comparisons.ResultsPeak concentrations of Δ9THC were reached at 2 h in the brain (15.9 ng/mg), blood (4.54 μg/mL), and plasma (4.56 μg /mL). The percentage of administered dose of Δ9THC transported to the brain (5.9%) was greater than in blood (1.7%), plasma (1.6%), urine (0.4%), and liver (0.1%). Concentrations of Δ9THC and its THC-COOH metabolite in the liver reached their highest levels at 8 h.DiscussionThe present study is the first to report the uptake and distribution across brain regions of Δ9THC and its principal metabolites following i.n. administration. The systemic bioavailability (absorption into the blood) of intranasal Δ9THC was 1.7% of the administered dose, much lower than that reported by others after oral ingestion (7–10%) and inhalation (20–35%), but those prior studies did not measure the transport of Δ9THC into brain regions. Others have reported Δ9THC in the whole brain following i.n. instillation in a different species (rats) to be twice (5.9%) that following i.p. injections, while metabolites of Δ9THC in rat brain were lower after i.n. administration.ConclusionsThe intranasal route of a Δ9THC nanoformulation is an effective way to deliver cannabinoids to the brain, especially in those who cannot take the medication orally. Going forward, a metered dosing nasal spray will provide accurate and consistent doses.
Field evaluation of the novel One Step Malaria Pf and Pf/Pv rapid diagnostic tests and the proportion of HRP-2 gene deletion identified on samples collected in the Pwani region, Tanzania
Authors: Mwangonela Zena E. , Ye Young , Rachel Qin , Msuya Hajirani M. , Mwamlima Tunu G. , Mswata Sarah S. , Chaki Prosper P. , Kimaro Ester G. , Mweya Clement N. , Mpina Maxmillian G. , Mwangoka Grace W. 
Published: February 2023

Abstract
Background
Malaria rapid diagnostic tests (mRDTs) have played an important role in the early detection of clinical malaria in an endemic area. While several mRDTs are currently on the market, the availability of mRDTs with high sensitivity and specificity will merit the fight against malaria. We evaluated the field performance of a novel One Step Malaria (P.f/P.v) Tri-line and One Step Malaria (P.f) rapid test kits in Pwani, Tanzania.

Methods
In a cross-sectional study conducted in Bagamoyo and Kibiti districts in Tanzania, symptomatic patients were tested using the SD BIOLINE, One Step Malaria (P.f/P.v) Tri-line and One Step Malaria (P.f) rapid test kits, microscope, and quantitative Polymerase Chain Reaction (qPCR). An additional qPCR assay was carried out to detect Histidine-Rich Protein 2 (HRP-2) gene deletion on mRDT negative but microscope and qPCR positive samples. Microscope results confirmed by qPCR were used for analysis, where qPCR was used as a reference method.

Results
The sensitivity and specificity of One Step P.f/P.v Tri-line mRDTs were 96.0% (CI 93.5–97.7%) and 98.3% (CI 96.8–99.2%), respectively. One Step P.f mRDT had sensitivity and specificity of 95.2% (CI 92.5–97.1%) and 97.9% (CI 96.3–99.0%) respectively. Positive predictive value (PPV) was 97.6% (CI 95.4–98.7%) and negative predictive value (NPV) was 96.2% (CI 95.5–98.3%) for the One Step P.f/P.v Tri-line mRDTs respectively, while One Step P.f mRDT had positive predictive value (PPV) and negative predictive value (NPV) of 97.0% (CI 94.8–98.3%) and 96.7 (CI 94.9–97.9%) respectively. 9.8% (CI 7.84–11.76) of all samples tested and reported to be malaria-negative by mRDT had HRP-2 gene deletion.

Conclusion
One Step Malaria P.f/P.v Tri-line and One Step Malaria P.f rapid test kits have similar sensitivity and specificity as the standard mRDT that is currently in the market, demonstrating the potential to contribute in the fight against malaria in endemic settings. However, the identified malaria parasites population with HRP-2 gene deletion pose a threat to the current mRDT usability in the field and warrants further investigations.
The value of magnetic resonance neurography in evaluation of sciatic neuropathy
Authors: Abd El-Azeem Esraa Hessin Youssef , Saleh Rasha Aly , Alarabawy Reda , El-Ahwal Hanan Mohamed Saleh 
Published: February 2023

Abstract
Background
Sciatic neuropathy is one of the most common neuropathies of the lower extremities. One of the most common presentations of sciatic neuropathy is foot drop and may also be associated with several other clinical (sensory and/or motor) presentations. In recent years, magnetic resonance imaging (MRI) has established itself as an important tool for the study of peripheral nerves, especially after the development of protocols including sequences optimized for this purpose, referred to as magnetic resonance neurography (MRN), being used as noninvasive means of diagnosing peripheral nerve disease. Such high-resolution imaging protocols aimed to image the nerves at hip, thigh, knee, leg, ankle, and foot and can demonstrate traumatic or iatrogenic injury, tumor-like lesions, or entrapment of the nerves, causing a potential loss of motor and sensory function in the affected area. This study aimed to be familiar with MRI and MRN findings in patients with sciatic neuropathy.

Results
In this prospective study, thirty patients presented with clinical manifestations and/or electrophysiological studies having sciatic neuropathy and underwent MRI and MRN at a university Hospital from March 2021 to March 2022. In view of clinical presentation, muscle weakness (66.67%), numbness and tingling (60%), and sensory manifestation (60%) were the most prevalent presenting manifestation followed by back pain (43.33%), foot drop (33.33%), and urinary and bowel incontinence (23.33%). MRN and MRI results showed a strong correlation with the presenting symptoms of participants, in the form of increased sciatic nerve caliber in 23.33%, muscular atrophy in 13.33%, nerve root impingement in 26.67%, and lumbar spondylosis in 36.67%. MR neurography sequences gave additional findings to the conventional MRI in the form of increased nerve signal intensity in 53.33%, perineural edema in 50% of cases, neural structure disruption in 26.67%, muscular impend denervation in 16.67%, bone marrow edema in 30.33%, pseudo-meningocele in 13.33%, and nerve root avulsion in 3.33% with no correlated findings in MRI.

Conclusions
MRN is an additional accurate tool in the study of different sciatic nerve diseases and can also give detailed knowledge of the nerve anatomy, adding value to electrophysiological studies and conventional MRI.
The Elusive Neuroendocrine Tumor: Finding the Ectopic ACTH Source 16 Years After the Diagnosis of Cushing Syndrome
Authors: Smushkin Galina , Phillips Richard , Chausse Guillaume 
Published: February 2023

Abstract
Ectopic adrenocorticotropin hormone (ACTH) syndrome (EAS) accounts for the minority of cases of Cushing syndrome. Up to 20% of these cases remain occult, despite multiple imaging attempts to localize the ACTH-producing tumor. Here we describe long-term follow-up of a 41-year-old woman, with ectopic Cushing syndrome initially classified as occult due to negative localization studies, who had bilateral adrenalectomy to manage hypercortisolism. After 16 years and many computed tomography (CT) scans, magnetic resonance imaging scans, Octreoscans, and 2 exploration surgeries for false positives on imaging, the source of ectopic ACTH production was localized in the pancreas utilizing molecular imaging with gallium-68 somatostatin receptor–targeted positron emission tomography (PET)/CT and fluorine-18 fluorodeoxyglucose PET/CT. She underwent a distal pancreatectomy, and pathology confirmed a 1.7-cm well-differentiated pancreatic neuroendocrine tumor with a moderately strong reactivity to ACTH stain. This case demonstrates the utility of multiple functional imaging modalities in resolving these “cold cases” of occult ectopic Cushing syndrome and the importance of a timely management of hypercortisolism with bilateral adrenalectomy.