bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penyuluhan Dampak Penggunaan Gadget Terhadap Tumbuh Kembang Anak di Era Digital bagi Orang Tua Desa Pongkar
Authors: Hilmy Zakwan , Susilo Trisno , Waidah Dina Fara , Adi Fajar Tyas , Ashari Widi Suyudi 
Published: April 2023

Gadget adalah suatu peranti elektronik yang memiliki fungsi praktis dalam mempermudah pekerjaan manusia. Berkembangnya teknologi membuat gadget semakin berkembang pesat menjangkau hampir seluruh lapisan masyarakat dan berbagai usia. Penggunaan yang berlebihan dari gadget tentunya memberikan dampak negatif khususnya terhadap tumbuh kembang anak. Di era digital ini gadget sudah sulit dipisahkan dari keseharian anak padahal anak-anak memilki fase pertumbuhan dan perkembangan yang kritis terhadap lingkungan disekitarnya. Oleh sebab itu diadakan suatu kegiatan pengabdian kepada masyarakat dengan tujuan menambah wawasan dan rasa antisipatif orang tua terhadap dampak penggunaan gadget yang berlebihan oleh anak khususnya anak usia dini. Kegiatan Pengabdian kepada Masyarakat (PkM) ini dilakukan dengan metode penyuluhan dan sosialisasi kepada para orang tua di Desa Pongkar. Kegiatan ini dilaksanakan pada tanggal 19 Juli 2022 di Aula Posyandu Desa Pongkar Kecamatan Tebing dengan jumlah psesrta yang hadir berjumlah 19 orang. Adapun dampak gadget berpengaruh pada perkembangan kognitif, mototrik, fisik, emosi, sosial, bahasa, dan seksual anak dimasa pertumbuhannya. Hasil dari kegiatan ini adalah pemaham peserta terkait materi sebesar 94,7% dimana hasil ini didapat dari penyebaran kuesioner feedback kegiatan. Diharapkan dari kegiatan ini orang tua semakin melek teknologi guna mengontrol penggunaan gadget oleh anak.A gadget is an electronic device with a practical function in facilitating human work. Technology development has caused gadgets to grow rapidly, reaching almost all levels of society and all ages. Overuse of gadgets certainly has a negative impact, particularly on the growth and development of children. In this digital era, gadgets are difficult to separate from children's daily lives, even though children have a critical growth and development phase in the surrounding environment. Therefore, a community service activity was carried out to add insight and anticipatory feelings for parents regarding the impact of excessive use of gadgets by children, especially in early childhood. This Community Service (PkM) activity was carried out using counselling and outreach methods to parents in Pongkar. This activity was carried out on July 19 2022, at the Posyandu Hall in Pongkar Village, Tebing District, with 19 participants attending. The impact of gadgets affects the cognitive, motor, physical, emotional, social, language, and sexual development of children during their growth. According to the feedback questionnaires distributed during the activity, 94.7% of the participants understood the material. It is hoped that from this activity, parents will become more technology literate to control the use of gadgets by children.
Pemberdayaan Aset Perdikan Sunan Drajat Melalui Pengolahan Manilkara zapota dalam Pemulihan Ekonomi di masa Covid 19
Authors: Ulum Miftachul , Mun'im Abdul , Muslih Muslih 
Published: April 2023

Pemberdayaan dengan pendekatan ABCD (Asset Based Community Development) bertujuan memberikan keterampilan pengolahan buah sawo sebagai makanan olahan. Pendampingan ini dilaksanakan di desa Drajat kecamatan Paciran kabupaten Lamongan diikuti ibu-ibu rumah tangga sebanyak 20 peserta. Buah sawo yang tumbuh subur dan produktif bagi masyarakat dapat dikreasikan menjadi beberapa produk olahan. Masyarakat desa Drajat selama ini memperlakukan buah sawo hanya sebagai makanan siap di makan dan hanya sebagai barang dagangan di area Wisata Religi Makam Sunan Drajat. Hasil pengabdian masyarakat melalui pelatihan kreasi buah sawo menghasilkan enam jenis kreasi produk olahan buah sawo. Keenam kreasi olahan bahan dasar buah sawo tersebut meliputi sale sawo, selai sawo, puding sawo, stick sawo, bolu sawo dan sirup sawo. Dapat disimpulkan bahwa kegiatan pendampingan yang dilaksanakan sejak tanggal 5 November - 15 Desember 2022 telah memberikan dampak positif kepada masyarakat desa Drajat Paciran Lamongan berupa ketrampilan dalam kreasi olahan produk buah sawo, meningkatan perekonomian masyarakat dengan penjualan berbagai macam jenis produk dari sawo, menciptaaan lapangan kerja baru dan menciptakan citra positif dengan produk olahan sawo di area Wisata Religi Makam Sunan Drajat.Empowerment with the ABCD (Asset Based Community Development) approach aims to provide processing skills and create sapodilla as processed food. This assistance was carried out in Drajat village, Paciran sub-district, Lamongan district, which 20 housewives attended. Sapodilla fruit that thrives and is productive for the community can be created into several processed products. The people of Drajat village have so far treated sapodilla fruit only as ready-to-eat food and only as merchandise in the Religious Tourism area of Sunan Drajat's Tomb. The results of community service through training on sapodilla fruit creations resulted in six types of sapodilla processed product creations. The six creations are made from sapodilla fruit basic ingredients include sapodilla sale, sapodilla jam, sapodilla pudding, sapodilla stick, sapodilla cake and sapodilla syrup. It can be concluded that the mentoring activities carried out from November 5 - December 15 2022, have had a positive impact on the Drajat Paciran Lamongan village community in the form of skills in the creation of processed sapodilla fruit products, improving the community's economy by selling various types of sapodilla products, creating new jobs and creating a positive image with processed sapodilla products in the Sunan Drajat Cemetery Religious Tourism area.
Workshop Pembuatan Buku Digital menggunakan Aplikasi Articulate Storyline bagi Guru SMPN 3 Tebat Karai
Authors: Handayani Dewi , Alperi Muzanip , Rohiat Salastri , Indriani Rini 
Published: April 2023

SMPN 3 Tebat Karai merupakan salah satu sekolah yang ada di Desa Tapak Gedung, Kabupaten Kepahiang yang memiliki sarana laboratorium komputer di sekolah. Akan tetapi pemanfaatan laboratorium komputer di sekolah masih belum maksimal, oleh karena itu perlu diadakan workshop yaitu berupa pelatihan dan pendampingan tentang pembuatan media berbasis informasi dan Teknologi (IT). Tujuan pengabdian ini untuk meningkatkan motivasi dan pengetahuan guru dalam membuat dan merancang media pembelajaran khususnya bahan ajar digital berbasis android menggunakan aplikasi articulate storyline serta mengetahui respon guru-guru SMPN 3 Tebat Karai terhadap kegiatan workshop bahan ajar digital berbasis android menggunakan aplikasi articulate storyline. Metode yang digunakan untuk kegiatan pengabdian ini adalah pembekalan/workshop, praktik terbimbing dan evaluasi. Peserta kegiatan adalah guru SMPN 3 Tebat Karai yang berjumlah 15 orang. Kegiatan pengabdian berlangsung dengan lancar, peserta sangat antusias terhadap materi yang disajikan tim. Sebanyak 75% peserta telah berhasil membuat bahan ajar menggunakan aplikasi articulate storyline. Dari angket yang disebarkan 100% guru sangat tertarik dengan materi pengabdian. 80% peserta memahami materi yang disampaikan tim pengabdian. Peserta berkomitmen untuk mencoba menerapkan bahan ajar yang telah dibuat kepada siswa di kelas setelah selesai kegiatan pengabdian berlangsung.SMPN 3 Tebat Karai is one of the schools in Tapak Gedung Village, Kepahiang Regency, which has computer laboratory facilities at the school. However, the utilization of computer laboratories in schools is still not optimal; therefore, it is necessary to hold workshops in the form of training and mentoring on creating Information and Technology (IT)-based media. This service aims to increase teacher motivation and knowledge in making and designing learning media, especially android-based digital teaching materials using the articulate storyline application, and to know the responses of SMPN 3 Tebat Karai teachers to Android-based digital teaching materials workshops using the articulate storyline application. The method used for this service activity is debriefing/workshop, guided practice and evaluation. The activity participants were 15 Tebat Karai SMPN 3 teachers. The service activities went smoothly; the participants were very enthusiastic about the material presented by the team. As many as 75% of participants have succeeded in making teaching materials using the articulate storyline application. From the questionnaires distributed, 100% of the teachers were very interested in the service material. 80% of participants understood the material presented by the service team. Participants are committed to applying the teaching materials made to students in class after the community service activities are finished.
Pemanfaatan Daya Tarik Wisata Melalui Pelatihan Penyusunan Paket Wisata Ready Made Tour
Authors: Rosalina Tita , Evita Rossi , Farizawati Farizawati , Septiani Rina , Nanda Indra 
Published: April 2023

Keindahan alam Desa wisata Sebubus memiliki berbagai daya Tarik wisata pantai, hutan mangrove, dan juga terdapat satwa langka seperti bekantan dan penyu. Desa ini merupakan salah satu desa yang terdapat di kabupaten Sambas Kalimantan barat yang memiliki letak sangat strategis yaitu berada di posisi ekor pulau Kalimantan yang berdekatan dengan wilayah perbatasan Indonesia-Malaysia timur. Dengan beragamnya daya tarik wisata yang ada, namun masyarakat setempat kurang memanfaatkan daya tarik wisata sebagai suatu usaha paket wisata yang dikarenakan oleh kurangnya kemampuan untuk menyusun paket wisata, terutama paket wisata ready made tour. Untuk mengatasi permasalahan tersebut dilakukan pendampingan maupun pelatihan kepada mitra yaitu kelompok sadar wisata sebubus yang dilaksanakan pada bulan September 2022. Tujuan dari pengabdian yang dilakukan adalah untuk memberikan pengetahuan dan keterampilan kepada mitra dalam memanfaatkan daya tarik wisata dan menyusun paket wisata. Pelaksanaan pendampingan dan pelatihan dilakukan dengan beberapa tahapan yaitu: tahap persiapan, pelaksanaan dan evaluasi. Metode yang digunakan yaitu: ceramah, tutorial/demonstrasi, latihan dan praktik. Tingkat pemahaman dan keterampilan mitra yang dilibatkan sebanyak 20 orang mengalami peningkatan sebesar 75%, yang diukur melalui tes awal dan tes akhir (pretest 10% dan posttest 85%). Dengan demikian usaha paket wisata readymade tour dapat dilaksanakan di desa wisata Sebubus. The natural beauty of Sebubus village offers various tourist attractions, beaches, mangrove forests, and endangered animals such as probosci's monkeys and sea turtles. Sebubus village is a tourist village in Paloh district, Sambas regency, West Kalimantan. The Sebubus tourism village is strategically located not far from the eastern Indonesia-Malaysia border region. However, the local community does not take advantage of tourist attractions as businesses, especially managing ready-made tour packages. They lack the skill to plan tour packages. To overcome these problems, mentoring and training were carried out to provide knowledge in promoting tourist attractions. The mentoring and training were carried out in several stages: preparation, implementation and evaluation. The methods used were lectures, tutorials/demonstrations, and practices. The pre-test measured the understanding and the success of mentoring and training. Post-test assessments were conducted on 20 participants (members of Pokdarwis of Sebubus village), held on September 2022. It shows that the participants' understanding increased by 75%, originally 10% to 85%. Therefore, the ready-made tour package business can be fruitful in Sebubus Tourism Village.
E-Module of Physics Science Integrated with Sustainable Development Goals to Enhance Students' Environmental Literacy
Authors: Pratiwi Hestiningtyas Yuli , Aji Sudi Dul , Hakim Arief Rahman , Sundaygara Chandra , Gurtin Anatolia , Hudha Muhammad Nur 
Published: April 2023

This study aims to produce a product of an electronic module on the subject of energy to enhance students' environmental literacy. This research was a research and development (R&D) using the ADDIE development model which includes: 1) the initial needs analysis stage to determine the needs of students and teachers, 2) the design stage which included collecting references, instruments and designing and creating an e-module of the science of physics integrated Sustainable Development Goals (SDGs), 3) the development of e-modules was carried out using the Canva application, Fliphtml and validation of material and media experts, 4) small-scale trials conducting interviews with students and teachers to obtain qualitative data in-depth, 5) evaluation from users, namely students and subject teachers. The assessment included 1) a Media expert test; 2) a material expert test; 3) user tests; 4) a small-scale test. The results of this study showed that: (1) the SDGs integrated science e-module was produced to enhance students' environmental literacy (2) the quality of the science e-module for students was developed according to material experts and media experts to have very good quality (VG) with the ideal percentage of each 83.00% and 98.00%. (3) the teacher's response to the student module is Very Good (VG) with an ideal percentage of 98%. Meanwhile, the student's response to the student's science e-module is Strongly Agree with an ideal percentage of 83.00%. Based on the results of this study, it can be concluded that the Science E-Module Integrated to SDGs has met the criteria of being feasible and effective for enhancing students' environmental literacy skills seen from the responses of media experts, material expert responses, students’ responses and trials.
Design of Peptide-Guided Protein Degraders with Structure-Agnostic Language Models
Authors: Brixi Garyk , Ye Tianzheng , Palepu Kalyan , Hong Lauren , Yudistyra Vivian , Vincoff Sophia , Christopher Jayani , Li Xinning , Bhat Suhaas , Monticello Connor , Lopez-Barbosa Natalia , Petersen Lillian , Zang Tian-Lai , Liu Tong , Zhao Lin , Zhang Sue , Ponnapati Manvitha , Tysinger Emma , Stan Teodora , Koseki Sabrina , DeLisa Matthew , Chatterjee Pranam 
Published: April 2023

Abstract
Here, we integrate fine-tuned protein language models and protein-protein interaction databases to develop a Structure-agnostic Language Transformer & Peptide Prioritization module that efficiently selects peptides from interaction interfaces, without the need for structural information. We experimentally fuse SaLT&PepPr-derived “guide” peptides to E3 ubiquitin ligase domains and reliably identify candidates that induce robust intracellular degradation of clinically-relevant targets, and exhibit high binding affinities, low off-targeting rates, and functional transcriptional effects.
Time restricted fasting improves liver steatosis in non-alcoholic fatty liver disease – a single blinded cross over trial
Authors: Feehan Jack , Mack Alexandra , Tuck Caroline , Tchongue Jorge , Holt Darcy , Sievert William , Moore Gregory , de Courten Barbora , Hodge Alexander 
Published: April 2023

Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is associated with visceral adiposity. We assessed the effectiveness of intermittent fasting (IF) for 16 hours daily without calorie restriction, compared to standard care (SC; diet and lifestyle advice) in improving visceral adiposity and steatosis by controlled attenuation parameter (CAP).
Methods: In a prospective single-blind randomized controlled trial, 32 participants with NAFLD were randomly assigned to IF or SC for 12 weeks. Secondary endpoints were changes in liver stiffness, anthropometry, blood pressure, and other metabolic factors.
Results: Twenty-eight participants completed the first arm of the study (IF = 14, SC = 14), with 23 completing the cross over arm (IF = 10, SC = 13). Baseline demographics were similar between the groups. Intermittent fasting caused a significant decrease in hepatic steatosis (p = 0.038), weight (p=0.005), waist circumference (p=0.001), and BMI (p=0.005) compared to standard care. Intermittent fasting also resulted in additional within group changes, not seen in the standard care intervention.
Conclusion: IF offers superior improvements in patients with NAFLD, improving steatosis, weight and waist circumference, despite no change in overall caloric intake. Time restricted fasting should be considered as a primary weight loss intervention in the context of NAFLD.
Trial registration: ACTRN12613000935730
Cannulated screw fixation assisted by a self-designed guide for the treatment of Garden stage I-III femoral neck fracture: A retrospective case-series study
Authors: Li Jianwen , Wang Cheng , Wang Xiao , Chen Cheng , Jiang Jiantao 
Published: April 2023

Abstract

Purpose: To explore the effects of a self-designed Kirschner wire guiding and adjustment apparatus for internal fixation with cannulated screws for the treatment of femoral neck fracture.
Methods: We retrospectively reviewed the patients with femoral neck fracture (Garden I-III) treated at our hospital between 01/2018 and 3/2022. The cases were included in the present study according to the inclusion and exclusion criteria. The operation time, The times of provisional Kirschner wires(K-wires) insertion, times of fluoroscopy , estimated blood loss in operation, Harris score, and VAS score of the hip joint were recorded and analyzed.
Results: Forty patients were included (13 females and 17 males, (median, 58 years of age), with 20 patients in the unguided and 20 in the guided groups, respectively. Their body mass index (BMI) was 23.03±1.86 kg/m2. Compared with the unguided group, the guided group showed shorter operation time (median 0.20 vs. 0.43 h, P<0.001), less blood loss (median, 2 vs. 20 mL, P<0.001), less Insertion times of Kirschner wire (median, 7 vs. 15, P<0.001) and fluoroscopy times (median 12 vs. 20, P<0.001). The VAS score (median, 1vs. 1, P=0.359)and Harris score (92.75±4.83 vs. 89.75±5.20, P=0.066).shows no significant difference between groups at the final follow-up.
Conclusions: Using theself-designed Kirschner wire guiding and adjustment apparatus during fixation of femoral neck fracture with cannulated screws reduces the operation time, blood loss, insertion times of Kirschner wire and fluoroscopy. This might promote the recovery of patients. Those results should be confirmed in further studies.
Levels of Evidence: Level IV
The Efficacy and Safety of the Sphingosine-1-Phosphate Receptor Agonist Fingolimod in Cerebrovascular Stroke: A Systematic Review and Meta-analysis
Authors: Aljabali Ahmed , Abdelhady Mariam , Altal Mohamed khadr , Negida Ahmed , Masadeh Majed Mohammad , Alrabadi Nasr Salieba 
Published: April 2023

AbstractIntroduction: Stroke is a leading cause of morbidity and mortality worldwide, with limited effective treatment options. Fingolimod has been shown to have neuroprotective effects in previous studies and has been approved for use in multiple sclerosis. This systematic review aims to evaluate the current evidence regarding the efficacy of Fingolimod in cerebrovascular stroke.Methods: A comprehensive literature search was conducted using electronic databases (PubMed, Scopus, Cochrane Library, and Web of Science) for studies published up to January 2023. Studies were included if they evaluated the efficacy of Fingolimod in subjects with cerebrovascular stroke and reported outcomes.Results: This meta-analysis included six studies with a total of 251 patients, 124 in the fingolimod group and 127 in the control group. Fingolimod was associated with significant improvements in NIHSS scores on days 7, 14, 30, and 90 post-stroke, with the greatest improvement seen after one month (MD = -7.1, 95% CI [-9.73, -4.65], P < 0. 00001). Additionally, fingolimod was associated with significant reductions in mRS scores after three months (MD = 7.3, 95% CI [3.06, 17.40], P < 0. 00001) and significant improvements in Modified Barthel Index scores on days 7, 14, 30, and 90 post-stroke. After three months, the mean difference in Modified Barthel Index scores was 14.6 (95% CI [5.80, 23.36], P = 0.0005). Fingolimod was also associated with significant reductions in microvascular permeability ratio (rT%) and infarct volume (MD = -15.2, 95% CI [-23.33, -7.15], P < 0. 00001).Conclusion: The current evidence suggests that Fingolimod may have potential as a neuroprotective agent in cerebrovascular stroke. However, more high-quality clinical trials are warranted.
Prevalence and influencing factors of sleep disorders among preschool children in Urumqi city: A cross-sectional survey
Authors: Gao Yongwei , xu peiru , Aizetiguli Maiming , Surong Shan , Zhu Zhaoxuan , Zhang Jing 
Published: April 2023

Abstract
Background: Sleep disorders refer to physiological and psychological states that cause adverse consequences due to the inability to fall asleep or poor sleep quality. The prevalence of sleep disorders varies greatly in different countries and regions due to different causes. This study aimed to investigate the prevalence and influencing factors of sleep disorders among preschool children in Urumqi city, China.
Methods: A cross-sectional study was conducted with stratified random cluster sampling. Children aged 3–6 years old in one kindergarten randomly selected from each of the 8 districts of Urumqi from March to July 2022, and their parents were surveyed with a sleep quality questionnaire.
Results: The prevalence of sleep disorders among preschool children in Urumqi was 14.29% (191/1336), and the prevalence of different symptoms was 42.81% for limb movements, 19.61% for snoring, 18.11% for molars, 16.39% for balderdash, 12.57% for sweating, 11.60% for nocturnal awakening, 8.46% for nightmares, 6.89% for bed wetting, 3.74% for apnea, and 3.29% for sleepwalking. The prevalence of body movements, snoring, sweating, night-wake, nightmares, bed-wetting, apnea, and sleepwalking among different ethnicities were significantly different (P<0.05). Multivariate analysis revealed that the major risk factors of sleep disorders were difficulty adapting to new environments, unwillingness to express emotions, inconsistent attitudes of the family toward children’s education, running before bed, strict family education methods, etc.
Conclusion: The prevalence of sleep disorders in preschool children in Urumqi is lower than the average level reported in other studies. Many factors affect the prevalence of sleep disorders in preschool children, but it is necessary to focus on the ability to adapt to new environments, psychological problems, and the impact of family education on sleep disorders. Further studies on the prevention and treatment of sleep disorders are needed for different ethnicities.