bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing team science in an academic medical center: A qualitative examination of investigator perspectives
Authors: Surratt Hilary L. , Otachi Janet K. , Slade Emily , Kern Philip A. , King Victoria , Kelly Thomas H. , DiPaola Robert S. 
Published: January 2023

Abstract

Introduction:
Optimizing the effectiveness of a team-based approach to unite multiple disciplines in advancing specific translational areas of research is foundational to improving clinical practice. The current study was undertaken to examine investigators’ experiences of participation in transdisciplinary team science initiatives, with a focus on challenges and recommendations for improving effectiveness.

Methods:
Qualitative interviews were conducted with investigators from twelve multidisciplinary teams awarded pilot research funding by the University of Kentucky College of Medicine to better understand the barriers and facilitators to effective team science within an academic medical center. An experienced qualitative researcher facilitated one-on-one interviews, which lasted about one hour. Structured consensus coding and thematic analysis were conducted.

Results:
The sample was balanced by gender, career stage (five were assistant professor at the time of the award, seven were senior faculty), and training (six were PhDs; six were MD physicians). Key themes at the team-level centered on the tension between clinical commitments and research pursuits and the limitations for effective team functioning. Access to tangible support from home departments and key university centers was identified as a critical organizational facilitator of successful project completion. Organizational barriers centered on operationalizing protected time for physicians, gaps in effective mentoring, and limitations in operational support.

Conclusions:
Prioritizing tailored mentoring and career development support for early career faculty, and particularly physician faculty, emerged as a key recommendation for improving team science in academic medical centers. The findings contribute to establishing best practices and policies for team science in academic medical centers.
Reviewing the experience with the repatriation of sacred ceremonial objects: A comparative legal analysis of Canada and South Africa
Authors: Ingelson Allan , Owosuyi Ifeoma 
Published: January 2023

AbstractRecent global interest in preserving cultural identity and heritage for the future of previously colonized Indigenous groups has prompted the resuscitation of local and Indigenous cultures from the brink of extinction. The pertinence of protecting and managing cultural heritage as an endowment that transcends generations of people and serves as a ligature between their past, present, and future cannot be overstated. In this respect, the repatriation or restitution of sacred ceremonial objects (SCOs) and cultural artifacts constitutes an integral aspect of reviving Indigenous people’s cultural and living heritage, which has been eroded by colonialism and other forms of occupation. In Alberta, Canada, the First Nations Sacred Ceremonial Objects Repatriation Act is the foremost legislation that provides a formal mechanism for the return of SCOs to the First Nations. Thus far, it has successfully facilitated the repatriation of several hundred repatriated several SCOs. In contrast, South Africa’s primary heritage legislation, the National Heritage Resources Act, lacks direction and detail on the restitution of SCOs, specifically to cultural communities. With the aid of a comparative approach, this article critically examines one successful approach to the repatriation of specific sets of heritage objects in Canada and analyzes South Africa’s legal frameworks that consider SCOs as a component of its national estate within its framework for restitution and the promotion of cultural revival in cultural communities.
The protection of movable cultural property in wartime: Pre-conflict planning in Sweden
Authors: Legnér Mattias 
Published: January 2023

AbstractModern warfare has prompted states to protect collections of cultural property by evacuating them to safe locations at times of war. Building on previously classified documents in archives, inquiries and other sources, this article investigates how planning for such evacuation was carried out in Sweden from 1939 to the 1990s. After the end of the Cold War, existing evacuation plans were finally scrapped. Due to the worsening security situation in the region, Swedish heritage institutions today need to build preparedness anew. It is shown that the evacuation of large volumes of property out of cities for practical reasons never was a realistic scenario, but probably should be restricted to a minimum of carefully selected objects, records and books. The process of selecting, transporting, finding safe locations to take the property to, and determining how to monitor it needs to be carefully planned during peaceful conditions in order to efficiently safeguard the collections in wartime. The relationship between Swedish planning and the 1954 Hague Convention, and how other states can learn from this study, is finally discussed.
International Conference “Decolonizing Heritage: The Return of Cultural Objects to Africa – An International Law Perspective,” 23–24 September 2021, Université de Genève
Authors: Plata Agnieszka 
Published: January 2023

AbstractThe conference report from the international conference “Decolonizing Heritage: The Return of Cultural Objects to Africa – An International Law Perspective,” which was held on 23–24 September 2021 at the Université de Genève.
First nests of Endangered Nordmann’s Greenshank Tringa guttifer found in over 40 years indicate nesting plasticity
Authors: Maslovsky Konstantin S. , Maleko Philipp N. , Pronkevich Vladimir V. , Slaght Jonathan C. , Powell Abby N. 
Published: January 2023

Summary
Knowledge of the breeding ecology of Endangered Nordmann’s Greenshank Tringa guttifer is necessary to develop a comprehensive species-specific conservation plan. We found nine greenshank nests in Schaste Bay, Russian Far East during the summers of 2019–2021. These are the first nests found in over 40 years and the only discovered to date on mainland Russia. In contrast to previous nest descriptions, we found greenshanks do not exclusively nest in trees, but also place nests on the ground at the base of mature or sapling larches. Our results indicate greenshanks may be larch obligates during the breeding season, and protecting coastal larch forest ecosystems near bogs, meadows, and mudflats throughout the Russian Far East may be critical to the species’ conservation.
The Dobbs Decision: Can It Be Justified by Public Reason?
Authors: Fleck Leonard M. 
Published: January 2023

AbstractJohn Rawls has held up as a model of public reason the U.S. Supreme Court. I argue that the Dobbs Court is justifiably criticized for failing to respect public reason. First, the entire opinion is governed by an originalist ideological logic almost entirely incongruent with public reason in a liberal, pluralistic, democratic society. Second, Alito’s emphasis on “ordered liberty” seems completely at odds with the “disordered liberty” regarding abortion already evident among the states. Third, describing the embryo/fetus from conception until birth as an “unborn human being” begs the question of the legal status of the embryo/fetus, as if an obiter dictum settled the matter. Fourth, Alito accuses the Roe court of failing to exercise judicial restraint, although Alito argued to overturn Roe in its entirety. In brief, the Dobbs opinion is an illiberal, disingenuous, ideological swamp that swallows up public reason and the reproductive rights of women.
Uncertainty in Simulating Twentieth Century West African Precipitation Trends: The Role of Anthropogenic Aerosol Emissions
Authors: Monerie Paul‐Arthur , Dittus Andrea J. , Wilcox Laura J. , Turner Andrew G. 
Published: January 2023

AbstractAnthropogenic aerosol emissions from North America and Europe have strong effects on the decadal variability of the West African monsoon (WAM). Anthropogenic aerosol effective radiative forcing is model dependent, but the impact of such uncertainty on the simulation of long‐term WAM variability is unknown. We use an ensemble of simulations with HadGEM3‐GC3.1 that span the most recent estimates in simulated anthropogenic aerosol effective radiative forcing. We show that uncertainty in anthropogenic aerosol radiative forcing leads to significant uncertainty at simulating multi‐decadal trends in West African precipitation. At the large scale, larger forcing leads to a larger decrease in the interhemispheric temperature gradients, in temperature over both the North Atlantic Ocean and northern Sahara. There are also differences in dynamic changes specific to the WAM (locations of the Saharan heat low and African Easterly Jet, of the strength of the West African westerly jet, and of African Easterly Wave activity). We also assess effects on monsoon precipitation characteristics and temperature. We show that larger aerosol forcing results in a decrease of the number of rainy days and of heavy and extreme precipitation events and warm spells. However, simulated changes in onset and demise dates do not appear to be sensitive to the magnitude of aerosol forcing. Our results demonstrate the importance of reducing the uncertainty in anthropogenic aerosol forcing for understanding and predicting multi‐decadal variability in the WAM.
Effect of Pore‐Wall Roughness and Péclet Number on Conservative Solute Transport in Saturated Porous Media
Authors: Ghanbarian Behzad , Mehmani Yashar , Berkowitz Brian 
Published: January 2023

AbstractWhile modeling solute transport has been an active subject of research in the past few decades, the influence of pore‐wall roughness on contaminant migration has not yet been addressed. We therefore conduct particle tracking simulations in three porous domains that have different pore‐wall roughness characteristics. Specifically, we consider five surface fractal dimensions ds = 1.0, 1.1, 1.2, 1.4, and 1.6, and four different Péclet numbers Pe = 10, 102, 103, and 105. Overall, arrival time distributions are simulated for 60 scenarios (3 domains 5 surface fractal dimensions 4 Péclet numbers) some of which show heavy‐tailed patterns indicating non‐Fickian transport. To interpret the simulations and quantify the transport behavior, we analyze the resulting arrival time distributions by the continuous time random walk (CTRW) approach. Results show that, on average, as the surface fractal dimension increases from 1.0 to 1.6, the CTRW model parameters , an exponent showing the degree of anomalous transport, v, the average solute velocity, and t2, the cut‐off time to Fickian transport, remain nearly constant. However, the dispersion coefficient, D, increases and the characteristic transition time, t1, decreases. We found t1 and D are more sensitive to pore‐wall roughness compared to the other CTRW parameters. We also found that as the Péclet number increases from 10 to 105, on average, v and D increase, t1 and decrease, and t2 remains nearly constant. The simulations demonstrate that the exponent and the dispersion coefficient are correlated to the average solute velocity.
Light People: Professor Peter Delfyett
Authors: Wang Hui 
Published: January 2023

EditorialIn this Information Age, computers and mobile phones are important carriers of data transmission and many scientists work hard to speed up that process. Professor Peter Delfyett of the University of Central Florida has done just that. A member of the US National Academy of Engineering, he developed the world’s fastest and most powerful mode-locked semiconductor laser. I have known Professor Delfyett since 2011, when he took part in the CIOMP-OSA International Summer Session. His sincere and friendly attitude, humorous and optimistic nature and excellent academic style left a deep impression. Driven by curiosity, human beings are constantly exploring the unknown, and asking questions. Einstein once suggested, defining what the problem is can be more important than solving it. And this is what Professor Delfyett has been advocating: pursue the ultimate academic goal, ask questions, believe in yourself and never give up. In addition, he has been striving to integrate industry and scientific research, so that scientific research results can truly benefit mankind. And now, please follow Light People to the latest cutting-edge progress in optics.
Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis
Authors: Liao Min , Liao Junwei , Qu Jiaquan , Shi Pan , Cheng Ying , Pan Qiong , Zhao Nan , Zhang Xiaoxun , Zhang Liangjun , Tan Ya , Li Qiao , Zhu Jin-Fei , Li Jianwei , Zhang Chengcheng , Cai Shi-Ying , Chai Jin 
Published: January 2023

AbstractTumor necrosis factor receptor superfamily member-12A (TNFRSF12A) plays a critical role in inflammation and cell death. It is expressed in multiple tissues yet extremely low in normal liver. To date, little is known about its role in cholestasis. Therefore, we sought to delineate the role of TNFRSF12A in cholestasis and its underlying mechanisms. Human liver tissues were collected from patients with obstructive cholestasis (OC) or primary biliary cholangitis (PBC). Tnfrsf12a knockout (KO) mice were generated. Cholestasis was induced by bile-duct ligation (BDL) or 0.1% 5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-feeding. Human hepatoma PLC/PRF/5-ASBT and THP1 cell lines or primary mouse hepatocytes were used for mechanistic studies. Hepatic TNFRSF12A expression was markedly increased in OC or PBC patients. Genetic ablation of Tnfrsf12a in BDL- and 0.1%DDC-induced cholestatic mice significantly attenuated cholestatic liver injury with remarkable reduction of hepatocyte pyroptosis but without changing scores of necroptosis and apoptosis. Morphological features of hepatocyte pyroptosis and increased levels of pyroptosis-related proteins, NLRP3, cleaved-Caspase-1, and cleaved-GSDMD in OC patients and BDL-mice confirmed this observation. Further mechanistic studies revealed that bile acids (BAs) induced TNFRSF12A expression by enhancing the transcription factor c-JUN binding to the TNFRSF12A promoter and subsequently initiated hepatocyte pyroptosis by the NFκB/Caspase-1/GSDMD signaling. Interestingly, TWEAK, a typical ligand of TNFRSF12A, secreted by infiltrated macrophages in cholestatic livers, enhanced TNFRSF12A-induced hepatocyte pyroptosis. Taken together, we report, for the first time, that hepatic TNFRSF12A is dramatically increased in human cholestasis. Deletion of TNFRSF12A inhibits BAs-induced hepatocyte pyroptosis through the NFκB/Caspase-1/GSDMD signaling and thereby ameliorates cholestatic liver injury. As such, targeting TNFRSF12A could be a promising approach to treating cholestasis.
METTL3 knockdown promotes temozolomide sensitivity of glioma stem cells via decreasing MGMT and APNG mRNA stability
Authors: Shi Jia , Zhang Peng , Dong Xuchen , Yuan Jiaqi , Li Yongdong , Li Suwen , Cheng Shan , Ping Yifang , Dai Xingliang , Dong Jun 
Published: January 2023

AbstractChemo-resistance hinders the therapeutic efficacy of temozolomide (TMZ) in treating glioblastoma multiforme (GBM). Recurrence of GBM even after combination of maximal tumor resection, concurrent radio-chemotherapy, and systemic TMZ applocation is inevitable and attributed to the high therapeutic resistance of glioma stem cells (GSCs), which can survive, evolve, and initiate tumor tissue remodeling, the underlying mechanisms of GSCs chemo-resistance, have not been fully elucidated up-to-now. Emerging evidence showed that METTL3-mediated N6-methyladenosine (m6A) modification contributed to the self-renew and radio-resistance in GSCs, however, its role on maintenance of TMZ resistance of GSCs has not been clarified and need further investigations. We found that the cell viability and half-maximal inhibitory concentration (IC50) of GSCs against TMZ significantly decreased after GSCs underwent serum-induced differentiation to adherent growth of tumor cells. Besides, METTL3 expression and total m6A modification declined dramatically in consistence with GSCs differentiation. Knockdown of METTL3 weakened self-renew, proliferation and TMZ IC50 of GSCs, whereas enhanced TMZ induced γH2AX level, indicating upregulation of double-strand DNA damage. We also found that mRNA stability of two critical DNA repair genes (MGMT and APNG) was regulated by METTL3-mediated m6A modification. In conclusion, we speculated that METTL3-mediated m6A modification of MGMT and APNG mRNAs played crucial roles on suppression of TMZ sensitivity of GSCs, which suggest a potential new therapeutic target of METTL3 against GBM.
MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer
Authors: Song Xiaoyu , Ji Jiayi , Rothstein Joseph H. , Alexeeff Stacey E. , Sakoda Lori C. , Sistig Adriana , Achacoso Ninah , Jorgenson Eric , Whittemore Alice S. , Klein Robert J. , Habel Laurel A. , Wang Pei , Sieh Weiva 
Published: January 2023

AbstractHuman bulk tissue samples comprise multiple cell types with diverse roles in disease etiology. Conventional transcriptome-wide association study approaches predict genetically regulated gene expression at the tissue level, without considering cell-type heterogeneity, and test associations of predicted tissue-level expression with disease. Here we develop MiXcan, a cell-type-aware transcriptome-wide association study approach that predicts cell-type-level expression, identifies disease-associated genes via combination of cell-type-level association signals for multiple cell types, and provides insight into the disease-critical cell type. As a proof of concept, we conducted cell-type-aware analyses of breast cancer in 58,648 women and identified 12 transcriptome-wide significant genes using MiXcan compared with only eight genes using conventional approaches. Importantly, MiXcan identified genes with distinct associations in mammary epithelial versus stromal cells, including three new breast cancer susceptibility genes. These findings demonstrate that cell-type-aware transcriptome-wide analyses can reveal new insights into the genetic and cellular etiology of breast cancer and other diseases.
DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells
Authors: Lauria Andrea , Meng Guohua , Proserpio Valentina , Rapelli Stefania , Maldotti Mara , Polignano Isabelle Laurence , Anselmi Francesca , Incarnato Danny , Krepelova Anna , Donna Daniela , Levra Levron Chiara , Donati Giacomo , Molineris Ivan , Neri Francesco , Oliviero Salvatore 
Published: January 2023

AbstractThe correct establishment of DNA methylation patterns during mouse early development is essential for cell fate specification. However, the molecular targets as well as the mechanisms that determine the specificity of the de novo methylation machinery during differentiation are not completely elucidated. Here we show that the DNMT3B-dependent DNA methylation of key developmental regulatory regions at epiblast-like cells (EpiLCs) provides an epigenetic priming that ensures flawless commitment at later stages. Using in vitro stem cell differentiation and loss of function experiments combined with high-throughput genome-wide bisulfite-, bulk-, and single cell RNA-sequencing we dissected the specific role of DNMT3B in cell fate. We identify DNMT3B-dependent regulatory elements on the genome which, in Dnmt3b knockout (3BKO), impair the differentiation into meso-endodermal (ME) progenitors and redirect EpiLCs towards the neuro-ectodermal lineages. Moreover, ectopic expression of DNMT3B in 3BKO re-establishes the DNA methylation of the master regulator Sox2 super-enhancer, downmodulates its expression, and restores the expression of ME markers. Taken together, our data reveal that DNMT3B-dependent methylation at the epiblast stage is essential for the priming of the meso-endodermal lineages and provide functional characterization of the de novo DNMTs during EpiLCs lineage determination.
Ethylene-triggered subcellular trafficking of CTR1 enhances the response to ethylene gas
Authors: Park Hye Lin , Seo Dong Hye , Lee Han Yong , Bakshi Arkadipta , Park Chanung , Chien Yuan-Chi , Kieber Joseph J. , Binder Brad M. , Yoon Gyeong Mee 
Published: January 2023

AbstractThe phytohormone ethylene controls plant growth and stress responses. Ethylene-exposed dark-grown Arabidopsis seedlings exhibit dramatic growth reduction, yet the seedlings rapidly return to the basal growth rate when ethylene gas is removed. However, the underlying mechanism governing this acclimation of dark-grown seedlings to ethylene remains enigmatic. Here, we report that ethylene triggers the translocation of the Raf-like protein kinase CONSTITUTIVE TRIPLE RESPONSE1 (CTR1), a negative regulator of ethylene signaling, from the endoplasmic reticulum to the nucleus. Nuclear-localized CTR1 stabilizes the ETHYLENE-INSENSITIVE3 (EIN3) transcription factor by interacting with and inhibiting EIN3-BINDING F-box (EBF) proteins, thus enhancing the ethylene response and delaying growth recovery. Furthermore, Arabidopsis plants with enhanced nuclear-localized CTR1 exhibited improved tolerance to drought and salinity stress. These findings uncover a mechanism of the ethylene signaling pathway that links the spatiotemporal dynamics of cellular signaling components to physiological responses.
Photosensitive ion channels in layered MXene membranes modified with plasmonic gold nanostars and cellulose nanofibers
Authors: Yeom Jeonghee , Choe Ayoung , Lee Jiyun , Kim Jeeyoon , Kim Jinyoung , Oh Seung Hak , Park Cheolhong , Na Sangyun , Shin Young-Eun , Lee Youngoh , Ro Yun Goo , Kwak Sang Kyu , Ko Hyunhyub 
Published: January 2023

AbstractIon channels transduce external stimuli into ion-transport-mediated signaling, which has received considerable attention in diverse fields such as sensors, energy harvesting devices, and desalination membrane. In this work, we present a photosensitive ion channel based on plasmonic gold nanostars (AuNSs) and cellulose nanofibers (CNFs) embedded in layered MXene nanosheets. The MXene/AuNS/CNF (MAC) membrane provides subnanometer-sized ionic pathways for light-sensitive cationic flow. When the MAC nanochannel is exposed to NIR light, a photothermal gradient is formed, which induces directional photothermo-osmotic flow of nanoconfined electrolyte against the thermal gradient and produces a net ionic current. MAC membrane exhibits enhanced photothermal current compared with pristine MXene, which is attributed to the combined photothermal effects of plasmonic AuNSs and MXene and the widened interspacing of the MAC composite via the hydrophilic nanofibrils. The MAC composite membranes are envisioned to be applied in flexible ionic channels with ionogels and light-controlled ionic circuits.