bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMULIHAN PENDIDIKAN PASCA PANDEMI MELALUI TRANSFORMASI DIGITAL DENGAN PENDEKATAN MANAJEMEN PENDIDIKAN ISLAM DI ERA SOCIETY 5.0
Authors: Latifah Latifah , Ngalimun Ngalimun 
Published: March 2023

Penelitian ini menggubakan metode kualitatif atau metode kepustakaan (library research). Penelitian kepustakaan adalah penelitian yang dilakukan dengan cara mengumpulkan data, informasi, dan berbagai macam data-data lainnya yang terdapat dalam kepustakaan. Dengan mengutarakan jenis penelitian ini, fokus dan langkah-langkah yang akan dalam penelitian ini menjadi semakin nampak dan jelas. Sumber data, tulisan ini sifatnya adalah kajian pustaka, maka obyek yang dapat dijadikan sumber dibagi menjadi dua, yaitu primer dan sekunder. Dalam penelitian ini pendekatan manajemen transformatif pendidikan Islam harus berprinsip pada landasan pendidikan Islam; prinsip tauhid, prinsip integrasi, prinsip keseimbangan, dan prinsip pendidikan seumur hidup. Pertama prinsip tauhid, dalam menghadapi era society 5.0 pendidikan Islam berperan menjadi tameng dalam mengkontrol ketidakselarasan hidup manusia muslim modern saat ini. Tauhid, merupakan bagian utama yang harus ditanam secara utuh dalam diri manusia sebab dengan tauhid inilah yang akan mengarahkan pada semua segi kehidupan manusia dan alam. Tauhid juga menjadi prinsip dasar telaah pemikiran Islam tentang cara pandang terhadap dunia.
Higher Education for Global and Local Sustainable Development
Authors: Zinevich O. V. , Melekhina E. A. 
Published: March 2023

The Russian universities’ contribution to the achievement of sustainable development goals is analyzed from the prospect of globalism crisis and transition to the global-local paradigm of the existence of a society. The authors proceed from the theoretical premise that the internationally recognized threefold concept of sustainable development encompassing economic development, social stability and environmental sustainability is based on the understanding of the development as a process and a result of subjective and objective factors that effective in activity aimed at building the future of the humankind. Sociocultural approach allows considering the universities’ practices on achieving global goals of sustainable development through local (national and cultural) practices: ecological, economical and socially oriented activity and/ or building ecosystems at a local level. The article is aimed to define the universities’ organizational environment and conditions providing the high level of sustainable development goals’ achievement.Universities implement various strategies to introduce the concept of sustainability into the programs of their development. The practices of the universities known for the effective implementation of sustainability concept into educational, research and social practices oriented to the regional sustainable development are analyzed. The universities under consideration provide stimulating ground for establishing horizontal and vertical relationships among all subjects of sustainable development within their educational environment, fostering sustainability culture and motivating students, teachers and other personnel to achieve sustainability goals. Their experience might be informative for Russian Universities as far as the principles of sustainable development and orientation at building educational ecosystems are formulated in the national programs of regional development in Russia (Flagship Universities Program and Priority 2030 Program). In the Priority 2030 Program, the ecosystem principle is one of the fundamental for the result-oriented innovative development of regional clusters created by the joint efforts of universities, businesses, state and social organizations. However, Russian universities in their striving for designing educational ecosystem mostly focus on research and financial aspects than on the development of a man, whose professional, intellectual and moral formation might contribute to the sustainable development of the region, the nation and the world.
Acute effects of vibration foam rolling on the explosive strength properties of the plantarflexors during maximal isometric contraction
Authors: Borisavljević Aleksandar , Kukić Filip , Ćosić Marko , Janković Goran , Dopsaj Milivoj 
Published: March 2023

BACKGROUND: Foam roller with vibration is a recent development and its implementation has not yet been provided with a sufficient scientific justification. Information on whether an implementation of vibration foam rolling for self-massage before the powerful muscular activities is a good strategy is scarce. OBJECTIVE: Therefore, the aim of this study was to determine the acute effects of a single 15-s and 60-s vibrating foam rolling treatment on muscle contractile properties during maximal voluntary isometric contraction (MVIC). METHODS: Twenty healthy and recreationally active subjects participated in this study. During first visit, baseline characteristics were collected, while on the second and third visit they performed a 15-s and a 60-s vibration foam rolling treatment, respectively. Their maximal force (F[Formula: see text] and rate of force development (RFD[Formula: see text]) were assessed using the MVIC of plantarflexors. RESULTS: The RFD[Formula: see text] was negatively affected ([Formula: see text] 0.05) after the 15-s treatment and 60-s treatment, staying reduced even after 10-min of recovery. No significant effects were observed for F[Formula: see text]. CONCLUSIONS: When implementing vibration foam rolling, either as a pre-workout activity or as a pre-competition treatment, caution should be taken. Short duration treatment should be avoided for activities were RFD[Formula: see text] has a significant impact on performance.
Post-Pandemic Relocation Preferences of Remote Tech Workers
Authors: Tan Simon , Fang Kevin , Lester T. William 
Published: March 2023

Will mass adoption of remote work lead to a mass exodus from Silicon Valley? A survey of over 660 high-tech workers in the San Francisco Bay Area ran from November 2021 to March 2022, asking about relocation interest and intended destinations. 53% of respondents expressed interest in moving or already moved, with post-pandemic preferences shifting towards suburbs and stand-alone homes. However, most moves merely represented a dispersal into Bay Area suburbs with a median relocation distance of 33.68km. The number of expected days in the office, dictated by employer remote work policies, significantly impacted relocation interest.
Risk factors for target vessel endoleaks after physician-modified fenestrated or branched endovascular aortic arch repair: A retrospective study
Authors: Chen Zhipeng , Fu Dongsheng , Liu Cheng , Jin Yi , Pan Chaohui , Mamateli Subinur , Lv Xiaochen , Qiao Tong , Liu Zhao 
Published: March 2023

ObjectiveFenestrated or branched endovascular aortic arch repair (fb-arch repair) is an effective option for treating complex aortic arch lesions, including thoracic aortic aneurysms and aortic dissections. However, the relatively high rate of re-intervention due to target vessel (TV)-related endoleaks have raised concerns. This study aimed to determine risk factors for TV-related endoleaks after fb-arch repair.MethodsThis was a retrospective analysis of all patients undergoing fb-arch repair between 2017 and 2021in nanjing drum tower hospital of China. All the patients underwent computed tomography angiography (CTA) before surgery; at discharge; and at 3 months, 6 months, and yearly post-discharge. All procedures are performed with physician modified grafts. Two experienced vascular surgeons used CTA and vascular angiography data to assess endoleaks. The study endpoints were mortality, aneurysm rupture, and emergence of and re-intervention for TV-related endoleaks.ResultsDuring the follow-up period, 218 patients underwent fb-arch repair. There were seven perioperative deaths and four deaths during follow-up (two myocardial infarctions and two malignancies). There were nine additional patients who were excluded from the study (two strokes, three with abnormal aortic arch anatomy, and four with insufficient clinical data). Among the 198 patients considered (mean age, 59 ± 13.3 years; 85% male), 309 branch arteries were revascularized. A total of 35 TV-related endoleaks were identified in 28 patients during a mean follow-up of 23 ± 14 months (median 23, IQR 26.3): six type Ic, 4 type IIIb, and 20 type IIIc endoleaks. Patients in the endoleak group had greater aortic arch segment diameters (43.1 ± 5.1 vs. 40.3 ± 4.7; P = 0.004) and a greater number of TVs revascularized (2.0 ± 0.8 vs. 1.5 ± 0.8; P = 0.004) than those in the non-endoleak group. However, the morphological classification of the aortic arch did not seem to affect the occurrence of TV endoleaks (13%, 14%, and 15% for type І, II, and III aortic arches, respectively; P = 0.957). Pre-sewing branch stents in the fenestration position reduced the risk of TV endoleaks (5% vs. 14%; P = 0.037). Additionally, in TVs affected by aortic aneurysm or dissection, the risk of endoleaks increased after reconstruction (17% vs. 8%; P = 0.018). The incidence of secondary TV-related endoleaks after fb-arch repair was 14.1%.ConclusionThe data from this study showed that the incidence of secondary target vessel related endoleaks after fb-arch repair is approximately 14.1%. Additionally, patients with a larger aortic arch diameter or more revascularized arteries during surgery were at increased risk TV-related endoleaks. The target vessels originating from the false lumen or aneurysm sac are more prone to endoleaks after reconstruction. Finally, prefabricated branch stents reduced risk of TV-related endoleaks.
Guided vs. conventional anti-platelet therapy for patients with acute coronary syndrome: A meta-analysis of randomized controlled trials
Authors: Zhong Peng-Yu , Deng Jian-Ping , Zhao Jing-Hong , Peng Lei , Liu Tao , Wang Hao-Yu 
Published: March 2023

BackgroundWhether guided antiplatelet therapy in patients with acute coronary syndrome (ACS) is effective in improving net clinical benefits compared with conventional antiplatelet therapy remains controversial. Therefore, we assessed the safety and efficacy of guided antiplatelet therapy in patients with ACS and undergoing percutaneous coronary intervention.MethodWe searched PubMed, EMBASE, and Cochrane Library databases to select the relevant randomized controlled trials comparing the guided and conventional antiplatelet therapy in patients with ACS. The primary and safety outcomes are major adverse cardiovascular events (MACE) and major bleeding, respectively. The efficacy outcomes included myocardial infarction, stent thrombosis, all-cause death, and cardiovascular death. We selected the relative risk (RR) and 95% confidence intervals (CIs) as effect size and calculated it using the Review Manager software. In addition, we evaluated the final results by trial sequential analysis (registered by PROSPERO, CRD 42020210912).ResultsWe selected seven randomized controlled trials and included 8,451 patients in this meta-analysis. Guided antiplatelet therapy can significantly reduce the risk of MACE (RR 0.64, 95% CI 0.54–0.76, P &lt; 0.00001), myocardial infarction (RR 0.62, 95% CI 0.49–0.79, P = 0.0001), all-cause death (RR 0.61, 95% CI 0.44–0.85, P = 0.003), and cardiovascular death (RR 0.66, 0.49–0.90, P = 0.009). In addition, there is no significant difference between the two groups in stent thrombosis (RR 0.67, 95% CI 0.44–1.03, P = 0.07) and major bleeding (RR 0.86, 95% CI 0.65–1.13, P = 0.27). The subgroup analysis showed that the guided group based on genotype tests could bring benefits in MACE and myocardial infarction.ConclusionsThe guided antiplatelet therapy is not only associated with a comparable risk of bleeding but also with a lower risk of MACE, myocardial infarction, all-cause death, cardiovascular death, and stent thrombosis than the conventional strategy in patients with ACS.
Insertable cardiac monitor with a long sensing vector: Impact of obesity on sensing quality and safety
Authors: Bisignani Giovanni , De Bonis Silvana , Pierre Bertrand , Lau Dennis H. , Hofer Daniel , Sanfins Victor Manuel , Hain Andreas , Cabanas Pilar , Martens Eimo , Berruezo Antonio , Eschalier Romain , Milliez Paul , Lüsebrink Ulrich , Mansourati Jacques , Papaioannou Georgios , Giacopelli Daniele , Gargaro Alessio , Ploux Sylvain 
Published: March 2023

BackgroundFat layers in obese patients can impair R-wave detection and diagnostic performance of a subcutaneous insertable cardiac monitor (ICM). We compared safety and ICM sensing quality between obese patients [body mass index (BMI) ≥ 30 kg/m2] and normal-weight controls (BMI &lt;30 kg/m2) in terms of R-wave amplitude and time in noise mode (noise burden) detected by a long-sensing-vector ICM.Materials and methodsPatients from two multicentre, non-randomized clinical registries are included in the present analysis on January 31, 2022 (data freeze), if the follow-up period was at least 90 days after ICM insertion, including daily remote monitoring. The R-wave amplitudes and daily noise burden averaged intraindividually for days 61–90 and days 1–90, respectively, were compared between obese patients (n = 104) and unmatched (n = 268) and a nearest-neighbour propensity score (PS) matched (n = 69) normal-weight controls.ResultsThe average R-wave amplitude was significantly lower in obese (median 0.46 mV) than in normal-weight unmatched (0.70 mV, P &lt; 0.0001) or PS-matched (0.60 mV, P = 0.003) patients. The median noise burden was 1.0% in obese patients, which was not significantly higher than in unmatched (0.7%; P = 0.056) or PS-matched (0.8%; P = 0.133) controls. The rate of adverse device effects during the first 90 days did not differ significantly between groups.ConclusionAlthough increased BMI was associated with reduced signal amplitude, also in obese patients the median R-wave amplitude was &gt;0.3 mV, a value which is generally accepted as the minimum level for adequate R-wave detection. The noise burden and adverse event rates did not differ significantly between obese and normal-weight patients.Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04075084 and NCT04198220.
Finding patterns of atoll morphometrics at a range of spatial scales
Authors: Johnson Faith M. , Ortiz Alejandra C. 
Published: March 2023

Small Island Nations, often comprised of Atolls, are at considerable risk of climate change impacts from sea-level rise to coral acidification to increasing cyclone intensity; understanding how they will change in the coming century is vital for climate mitigation and resiliency. However, the morphology of atolls are not well quantified or summarized. In this work, we calculate modern atoll morphometrics on a global scale including 3,786 motu and 593 reef flats on 154 atolls. Temporal composites of Landsat imagery are created for 4 years (2015–2018), and are classified into motu, reef flat, open water/lagoon via unsupervised classification. Morphometrics, including widths, lengths, and area, are computed for each motu and reef flat of the atoll in Python, creating a database of atolls and their associated morphometrics. Consistency in automated processing of atoll morphometrics removes spatial and user bias, enabling a better understanding of geographic patterns of atoll area and other morphometrics. Distinct differences in the distribution of motu are seen on a regional scale in French Polynesia, while globally, wider reef flats and larger motu are found closest to the equator. Globally, there is a consistent reef flat width in front of large motu (&gt;1 km length) of 184 ± 93 m (n = 724). Our atoll morphometric database creates a baseline of current atoll characteristics that can be expanded upon in the future and used for evaluating temporal changes to atoll islands.
Lipocalin 2 – mutation screen and serum levels in patients with anorexia nervosa or obesity and in lean individuals
Authors: Zheng Yiran , Rajcsanyi Luisa Sophie , Kowalczyk Manuela , Giuranna Johanna , Herpertz-Dahlmann Beate , Seitz Jochen , de Zwaan Martina , Herzog Wolfgang , Ehrlich Stefan , Zipfel Stephan , Giel Katrin , Egberts Karin , Burghardt Roland , Föcker Manuel , Al-Lahham Saad , Hebebrand Johannes , Fuhrer Dagmar , Tan Susanne , Zwanziger Denise , Peters Triinu , Hinney Anke 
Published: March 2023

ContextThe bone-derived adipokine lipocalin-2 is relevant for body weight regulation by stimulating the leptin-melanocortin pathway.ObjectiveWe aimed to (i) detect variants in the lipocalin-2 gene (LCN2) which are relevant for body weight regulation and/or anorexia nervosa (AN); (ii) describe and characterize the impact of LCN2 and MC4R variants on circulating lipocalin-2 level.MethodsSanger sequencing of the coding region of LCN2 in 284 children and adolescents with severe obesity or 287 patients with anorexia nervosa. In-silico analyses to evaluate functional implications of detected LCN2 variants. TaqMan assays for rare non-synonymous variants (NSVs) in additional independent study groups. Serum levels of lipocalin-2 were measured by ELISA in 35 females with NSVs in either LCN2 or MC4R, and 33 matched controls without NSVs in the two genes.ResultsFourteen LCN2-variants (five NSVs) were detected. LCN2-p.Leu6Pro and p.Gly9Val located in the highly conserved signal peptide region may induce functional consequences. The secondary structure change of lipocalin-2 due to LCN2-p.Val89Ile may decrease solubility and results in a low lipocalin-2 level in a heterozygotes carrier (female recovered from AN). Lean individuals had lower lipocalin-2 levels compared to patients with obesity (p = 0.033).ConclusionLipocalin-2 levels are positively associated with body mass index (BMI). Single LCN2-variants might have a profound effect on lipocalin-2 levels.
Using existing infrastructure as ground control points to support citizen science coastal UAS monitoring programs
Authors: Rabins Lucas F. , Theuerkauf Ethan J. , Bunting Erin L. 
Published: March 2023

Recent publications have described the ability of citizen scientists to conduct unoccupied aerial system (UAS) flights to collect data for coastal management. Ground control points (GCPs) can be collected to georeference these data, however collecting ground control points require expensive surveying equipment not accessible to citizen scientists. Instead, existing infrastructure can be used as naturally occurring ground control points (NGCPs), although availably of naturally occurring ground control point placement on such infrastructure differs from published best practices of ground control point placement. This study therefore evaluates the achievable accuracy of sites georeferenced with naturally occurring ground control points through an analysis of 20 diverse coastal sites. At most sites naturally occurring ground control points produced horizontal and vertical root mean square errors (RMSE) less than 0.060 m which are similar to those obtained using traditional ground control points. To support future unoccupied aerial system citizen science coastal monitoring programs, an assessment to determine the optimal naturally occurring ground control point quantity and distribution was conducted for six coastal sites. Results revealed that generally at least seven naturally occurring ground control points collected in the broadest distribution across the site will result in a horizontal and vertical root mean square errors less than 0.030 m and 0.075 m respectively. However, the relationship between these placement characteristics and root mean square errors was poor, indicating that georeferencing accuracy using naturally occurring ground control points cannot be optimized solely through ideal quantity and distribution. The results of these studies highlight the value of naturally occurring ground control points to support unoccupied aerial system citizen science coastal monitoring programs, however they also indicate a need for an initial accuracy assessment of sites surveyed with naturally occurring ground control points at the onset of such programs.
A flagellin-conjugate protein induces dual NLRC4- and NLRP3-inflammasome activation which modulates inflammatory cytokine secretion from macrophages
Authors: Lin Yen-Ju , Jamin Annette , Wolfheimer Sonja , Fiedler Anna , Junker Ann-Christine , Goretzki Alexandra , Scheurer Stephan , Schülke Stefan 
Published: March 2023

BackgroundA recombinant fusion protein combining the adjuvant and TLR5-ligand flagellin with the major birch pollen allergen Bet v 1 (rFlaA:Betv1) has been suggested to prevent the manifestation of birch allergy. Noteworthy, rFlaA:Betv1 induced both pro- and anti-inflammatory responses which were differentially regulated. However, the mechanism by which flagellin fusion proteins modulate allergen-specific immune responses, especially the mechanisms underlying IL-1β secretion and their contribution to the overall immune responses remains elusive.ObjectiveTo investigate the mechanisms underlying the production of IL-1β from rFlaA:Betv1 stimulated macrophages.MethodsMacrophages were derived from mouse peritoneal-, human buffy-coat-, and PMA-differentiated THP-1 (wild type or lacking either ASC, NLRP3, or NLRC4) cells. Macrophages were stimulated with non-modified rFlaA:Betv1, mutant variants lacking either the flagellin DC0 domain or a sequence motif formerly described to mediate TLR5-activation, and respective controls in the presence or absence of inhibitors interfering with MAPK- and NFκB-signaling. Cytokine secretion was analyzed by ELISA and intracellular signaling by Western Blot. To study the contribution of IL-1β to the overall immune responses, IL1R-deficient mouse peritoneal macrophages were used.ResultsrFlaA:Betv1 consistently activated all types of investigated macrophages, inducing higher IL-1β secretion compared with the equimolar mixture of both proteins. rFlaA:Betv1-induced activation of THP-1 macrophages was shown to be independent of either the TLR5-activating sequence motif or the flagellin DC0 domain but depended on both NLRP3- and NLRC4-inflammasomes. In addition, NFκB and SAP/JNK MAP kinases regulated rFlaA:Betv1-induced inflammasome activation and cytokine secretion by modulating pro-Caspase-1- and pro-IL-1β-expression in THP-1 macrophages. Finally, lack of IL-1β positive feedback via the IL1R strongly diminished the rFlaA:Betv1-induced secretion of IL-1β, IL-6, and TNF-α from peritoneal macrophages.ConclusionThe mechanisms contributing to rFlaA:Betv1-induced IL-1β secretion from macrophages were shown to be complex, involving both NLRC4- and NLRP3-inflammsomes, as well as NFκB- and SAP/JNK MAP kinase-signaling. Better understanding the mechanisms regulating the activation of immune cells by novel therapeutic candidates like the rFlaA:Betv1 fusion protein will allow us to further improve and develop new treatment strategies when using flagellin as an adjuvant.