bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stress lavorativo e burnout negli infermieri: analisi del fenomeno in terapia intensiva
Authors: Binda Filippo 
Published: August 2023

Introduzione:Â lo stress lavoro correlato Ã¨ una problematica impor- tante nel personale di terapia intensiva e puÃ² portare allo sviluppo della sindrome da burnout. Le caratteristiche dellâ€™ambiente lavora- tivo e lâ€™organizzazione stessa del lavoro hanno molta importanza per lâ€™insorgenza del burnout.
Lâ€™ambulatorio infermieristico ed il Fast Track in Pronto Soccorso: nuovi strumenti organizzativi dellâ€™assistenza
Authors: Andreucci Marida , Traini Tiziana , Cosignani Emanuela 
Published: August 2023

Da diversi anni uno dei maggiori problemi riscontrabile allâ€™interno dei Pronto Soccorso italiani Ã¨ rappresentato dal fenomenoÂ dellâ€™o- vercrowding, il sovraffollamento che si gene- ra in seguito allâ€™uso di tali strutture, a volte im- propriamente[1,2]. CiÃ² genera un conseguente aumento dei tempi di attesa per i codici a bassa prioritÃ ,[3]Â ed Ã¨ proprio sul trattamento di questi ultimi che viene posta lâ€™attenzione, alfine di evitare di incorrere nel rischio di esem- pi diÂ malpracticeÂ e di penalizzare coloro chepresentano problematiche piÃ¹ urgenti e com- plesse[4].
La presenza dei familiari durante le manovre di rianimazione: unâ€™indagine qualitativa in una Terapia Intensiva Generale
Authors: Giovannetti Matteo , Boni Davide , Ferri Paola , Girardis Massimo 
Published: August 2023

Â Nonostante molti studi confermino la volontÃ dei parenti di assistere alle manovre di rianimazione dei propri cari ricove- rati in unitÃ di terapia intensiva, questo accade raramente in Italia, anche nel caso di terapie intensive aperte ai famigliari. Le causesono diverse, ma spesso sono i professionisti infermieri e medici ad essere contrari per ragioni non del tutto chiarite,
Lâ€™applicazione del National Early Warning Score (NEWS) nelle emergenze territoriali
Authors: Loperfido Tracy , Calamita Cesare , Savoia Giovanni , Battista Antonia , Redmile Gordon Marc 
Published: August 2023

Una corretta valutazione delle condizioni cliniche del paziente riduce la mortalitÃ e lâ€™accesso improprio in terapia in-tensiva. La letteratura scientifica suggerisce lâ€™uso, per gli infermieri che lavorano in ospedale, del National Early Warning Score (NEWS),Â mentre nel Servizio dâ€™Emergenza 118 lâ€™attribuzione del codice colore identifica le condizioni cliniche di criticitÃ dei pazienti (D.M. 15/05/1992). Lasopravalutazione o la sottovalutazione della gravitÃ del paziente spesso causa lâ€™assegnazione di un codice colore errato.
Pazienti ad alta e bassa complessitÃ clinica: impatto sul carico di lavoro infermieristico
Authors: Lucchini Alberto , Vimercati Simona , Bertin Alice , Ciucur Mihaela , Coppolecchia Gessica , Giannini Luciano , Minotti Dario , Moretta Daniele , Rolli Barbara , Tancredi Valeria , Ceccarelli Stefania , La Marca Maria Assunta , Elli Stefano 
Published: August 2023

La grande eterogenicitÃ dei pazienti ricoverati in terapia intensiva ha amplificato la diseguaglianza tra gravitÃ clinica e complessitÃ assistenziale. In passato sono stati proposti in terapia intensiva dei sistemi che, basandosi sul numero di insufficienzeÂ dâ€™organo presenti nei pazienti, permettessero di identificare i pazienti a bassa versus alta complessitÃ .
La gestione dellâ€™ossigenoterapia ad alti flussi in un ospedale pediatrico italiano: uno studio osservazionale
Authors: Calza Simona , Da Rin Della Mora Roberta , Costa Elisabetta , Esibiti Fulvia , Subbrero Milvia , Scelsi Silvia 
Published: August 2023

Lâ€™ossigenoterapia ad alti flussi (High Flow Oxygen Therapy, HFOT) Ã¨ una metodica di supporto ventilatorio non invasivo in grado di erogare una miscela, umidificata e riscaldata, di aria e ossigeno attraverso cannule nasali non occludenti. Volendo ripensare la gestione infermieristica dellâ€™HFOT ed in mancanza di dati circa la sua gestione nel paziente pediatrico assistito presso lâ€™IRCCS Istituto Giannina Gaslini, Ã¨ stato condotto uno studio per descrivere il fenomeno e per ottenere informazioni utili al miglioramento della qualitÃ assistenziale.
Impact of Lifestyle on Psychological and Physiological Status of Individuals during Lockdown
Authors: Abishek J. R. , Vincent Jeyaraj D. 
Published: August 2023

Background:
Studies prove that individuals' psychological and physiological health is affected during lockdown which is due to their loss of autonomy, fear of disease, and reduced physical activity.

Objective:
The objective of this study was to find the possible impact that an individual's lifestyle has on his physiological and psychological status during this lockdown.

Materials and Methods:
A questionnaire was designed with questions interrogating their demographics and assessing their lifestyle, hobbies, their stress level, musculoskeletal pain, fatigue, and how they spent their time during this lockdown. The self-administered questionnaire was circulated online to people of both genders on all platforms.

Results:
The results showed that those who smoke were more distressed and experienced more pain than those who do not (P < 0.05). People with elevated blood pressure, diabetes, and other musculoskeletal pain were more stressed and experienced more pain and fatigue than those who were healthy (P < 0.005). People who practiced exercising and yoga were less stressed and stayed active with less or no pain and discomfort than the sedentary people (P < 0.05). Those who spend their time gardening and housekeeping felt healthier and more emotionally stable than the others (P < 0.05). The emotional disturbance had a weak positive significant correlation with onscreen time, sleep duration, and activities of daily living (ADL) limitation. Pain severity and fatigue had a weak positive significant correlation with onscreen time, sleep duration, and ADL limitation.

Conclusion:
People with increased physical activity and habit of regular exercise, yoga, and meditation were psychologically and physiologically healthier and were less affected by lockdown than the people with a sedentary lifestyle.
Effectiveness of Intraoperative Use of Tranexamic Acid in Total Knee Arthroplasty
Authors: Madhuchandra P , Hemachandra P 
Published: August 2023

Background:
Blood loss is among the commonly encountered problems in total knee arthroplasty (TKA) surgeries. Tranexamic acid (TXA) is commonly used intravenously to decrease the blood loss during TKA. However, it has got its own contraindications. In such patients, it can also be used locally to prevent blood loss. We assessed the effectiveness of local TXA by determining the amount of blood loss and transfusion required.

Materials and Methods:
A total of 60 patients with 72 TKA surgeries were included and analyzed in this observational prospective study. Three Gram of TXA was infiltrated locally into the tissues immediately after skin closure before the release of the tourniquet. The amount of blood loss was calculated by comparing the preoperative and postoperative hemoglobin (Hb) levels.

Results:
The mean blood loss in patients whom local TXA was used was 433.3 ml. The mean postoperative Hb loss was 1.01. Only one patient with bilateral TKA required postoperative blood transfusion. There were no issues with wound healing in any of our patients. The P value in Hb loss was 0.002 and in total blood was 0.001 and were statistically significant.

Conclusion:
Local use of TXA is very effective in reducing the amount of postoperative blood loss and the need for the blood transfusion. We recommend for the local use of TXA in primary knee arthroplasty surgeries.
A lexical review on Vishaghna Dravyas of Kaideva Nighantu
Authors: Yadav Sunita , Sharma Anita , Vishnoi Rinkesh , Rani Jyoti 
Published: August 2023

Introduction:
Agad Tantra being the unique branch that deals with toxicology and its management enlists several antitoxic drugs used for various poisonings. Ancient texts comprise the list of a wide range of traditional medicines, but they are not explored due to lack of incomprehension.

Aims:
The review has been written with the aim to dig out the hidden knowledge of Vishaghna Dravyas (alexeterics) mentioned in Kaiydeva Nighantu.

Materials and methods:
This Nighantu was written in the 15th century A. D. by Kaiydeva with the name “Pathya-Apathya-Vibodhaka” it comprising of total 514 Dravyas out of which 175 drugs possess Vishagna (anti-poisonous) property.

Results:
These Vishaghna Dravyas (alexeterics) have been distributed based on various Vargas (classes) which is described as 121 belonging to Ausghada Varga (drug class) as single drugs and four as groups, total of 16 from Dhatu Varga (metal class) as single drugs and one as compound or as a group, 9 from Dhanya Varga (cereal class) as a single drug, 15 in Dravya Varga as single drugs, and 5 as compound or as a group. Two each in Kritana Varga and Vihara Varga and one in Mansa Varga as compound or as a group. Out of all the 175 Vishagna Dravayas (alexeterics), 18 Dravyas (substances) are specific indications in combating particular types of envenomation or poisoning conditions.

Conclusion:
All the abovementioned drugs are screened for the purpose of revalidation to bring out their therapeutic utility.
Modulation of gut microbiota with Ayurveda diet and lifestyle
Authors: Chauhan Ashutosh , Semwal Deepak Kumar , Semwal Ruchi Badoni , Joshi Sunil Kumar , Adhana Rajesh Kumar , Goswami Madhavi Sanjay 
Published: August 2023

Background:
The prevalence of type 2 diabetes (T2D) has increased substantially in the past few decades throughout the world. In India, the epidemic of diabetes continues to increase irrespective of area, status, and age. Despite various scientific societies involved in the treatment of diabetes, still, the burden of diabetes keeps growing.

Aims:
The aim of this work is to explore the Ayurvedic concept of a personalized diet to modulate the gut microbiota for the treatment of T2D.

Material and methods:
A thorough study of literature from online scientific databases including Web of Science, PubMed, Scopus, and Google Scholar as well as from classical texts of Ayurveda was done. A careful compilation was done to extract the valuable output of the personalized diet to modulate the gut microbiota.

Results:
There are various diets used to control blood glucose levels, and their effects are also being studied on the transcriptome or epigenome despite 99.9% genomic similarity among human beings. However, microbiomes have only 10% similarity. Ayurvedic diet is given on the basis of Prakriti (body constitution), therefore, it is also called personalized diet.

Conclusion:
The diets prescribed for T2D in Ayurveda are high in fibers, polyphenols, and complex carbohydrates which enrich butyrate-producing bacteria and decrease lipopolysaccharide-producing bacteria. Hence, there is a need to have a personalized diet to manage the glucose level by enriching beneficial gut microbiota. The approach of a personalized diet associated with gut microbiota can be helpful in maintaining blood sugar in T2D patients.
A narrative review on types of data and scales of measurement: An initial step in the statistical analysis of medical data
Authors: Shukla Durgesh 
Published: August 2023

ABSTRACT
Statistical tools for data analysis differ for various data types and scales of measurements. The purpose of this review is to discuss these different types of data and measurement scales. To prepare this article, an online literature search was performed in Google and PubMed, using specific keywords. All relevant articles published in the English language between January 2010 and December 2022 were assessed for relevance. Screening of 34 articles was done and eventually 15 were included that had complete information. This review provides detailed information with examples regarding the data types and scales of measurement. Knowledge of the correct data type or scale of measurement is essential for the application of the appropriate statistical tools, and for making accurate inferences.
Safety and Efficacy of Golimumab in Rheumatoid Arthritis: A Prospective, Multicenter, Real-World Study from India
Authors: Pandey Bimlesh Dhar , Krishnamurthy Venkataraman , Kumar Uma , Upadhyaya Sundeep Kumar , Jain Neeraj , Dugar Manish , Panchal Sagar , Shah Nishita , Korde Tanuja , Dixit Jitendra 
Published: August 2023

Abstract

Background:
Tumor necrosis factor (TNF) has been associated with inflammation and joint destruction in patients with rheumatoid arthritis (RA), and several anti-TNF agents, including golimumab, are currently in clinical use. This postmarketing surveillance (PMS) study was carried out at six rheumatology centers in India to assess the safety and efficacy of golimumab in patients with moderate-to-severe RA, in a real-world setting.

Methods:
This was a prospective, multicenter, open-label, single-arm, PMS study, where golimumab 50 mg subcutaneous was administered monthly as per locally approved prescribing regulations. The primary endpoint was to assess the safety of golimumab. Health Assessment Questionnaire-Disability Index (HAQ-DI), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), auto-injector satisfaction/user-friendliness, injection-site pain/reactions, and 28-joint Disease activity score (DAS-28) including erythrocyte sedimentation rate (ESR) (DAS-28-ESR) and C-reactive protein (CRP) (DAS-28 CRP), were evaluated as per investigator’s routine practice.

Results:
Over 6 months, 120 patients were enrolled and 109 completed the study. Sixty-two (51.7%) patients experienced ≥1 treatment-emergent adverse events (TEAEs). The majority of TEAEs reported in the study were mild to moderate in severity. No deaths were reported. The mean (standard deviation [SD]) change from baseline in HAQ-DI (−0.9 [0.65]) and FACIT-F (14.8 [10.20]) suggested improvement in physical function and fatigue, respectively. The majority of patients (n = 77 [64.2%]) were “very satisfied” on the satisfaction/user-friendliness parameters of auto-injector and majority (n = 99 [91.7%]) did not experience injection-site reactions. Mean (SD) change from baseline of DAS-28 scores (not assessed for all patients; DAS-28 ESR [n = 62]: −2.0 [1.25]) indicated an improvement in disease activity.

Conclusions:
Golimumab (50 mg) in combination with methotrexate was found to be safe and well-tolerated in Indian patients with moderate-to-severe RA. No new safety signals emerged.
Molecular modeling, synthesis, and antiproliferative evaluation of new isoxazole ring linked by Schiff bases and azo bond
Authors: Taha Duha E. , Mahdi Monther F. , Raauf Ayad M. R. 
Published: August 2023

ABSTRACT
Lung cancer is the most common malignancy worldwide, with approximately 1.8 million new cases yearly. Cytotoxic drugs are frequently used in cancer treatment. Even though the medicine enhances patients’ quality of life, several drawbacks diminish its efficacy. Drug resistance and many disadvantages associated with chemotherapeutic drug side effects continue to be significant factors limiting the efficiency of cancer treatment. This necessitates developing new effective strategies that target tumors with minimal adverse effects. This research aims to overcome these issues by synthesizing a new series of compounds with an isoxazole ring attached by Schiff bases and azo bonds based on molecular docking with the (Genetic Optimization of Ligand Docking) program and estimating the pharmacokinetic properties with the Swiss ADME. The greatest-fitting compounds were then manufactured and verified by spectral analysis (FT-IR, 1H NMR, and 13C NMR), in vitro MTT assay for assessment of antiproliferative activities against A549 lung cancer cell lines showed that compounds 5a and 5b had an inhibitory concentration half-maximal inhibitory concentration (IC50) (17.34 and 18.32 μM), respectively, which was significantly lower than the inhibitory concentration of erlotinib (IC50 = 25.06 μM).
Awareness toward breast cancer and practice of breast self-examination among Iraqi female students at faculty of basic education
Authors: Hassan Nahed Ahmed 
Published: August 2023

ABSTRACT
The most prevalent cancer and the one with the highest fatality rate is breast cancer, accounting for 27% of all malignancies in women and ranking one among all cancers in women. It appears that breast cancer affects both developed and developing nations. Hence, raising public awareness of breast malignancy prevention strategies is crucial in lowering the morbidity and mortality associated with the disease. The awareness and practices of female undergraduate students at Tikrit University regarding breast self-examination (BSE) were evaluated in this study. This cross-sectional investigation was performed on 420 Iraqi undergraduate scholars at the Faculty of Basic Education, University of Tikrit. The students were polled online using a self-administrated Google Forms that was disseminated through social media. Microsoft Office Excel and SPSS version 22 were used to analyze the data that had been gathered. The majority of responders (70.2%) claimed to be knowledgeable about breast cancer. Out of the participants, around 31.8% expressed the belief that a positive family history, followed by obesity 18.9% was responsible for its occurrence. BSE as a technique to find breast cancer early was only known by 33.2% of individuals who were aware of breast cancer. The significant relationships between BSE practice and breast cancer were demonstrated (P = 0.01). Timely identification and treatment of breast cancer potentially lead to improved outcomes and complete recovery when individuals promptly report signs and symptoms. By promoting awareness of breast cancer and conducting BSE, it is possible to minimize the financial burden of the treatment plan and mitigate the impact of synonyms.
Aggressive behavior and its associated factors among persons with mental illness: An observational study
Authors: Parakkal Kurian Leemol , Rentala Sreevani , Belsiyal C Xavier , Srinivasan P , Govindar Thimmajja Sunanda 
Published: August 2023

BACKGROUND:
Aggressive behavior of psychiatric inpatients causes severe complications during treatment; nursing staff needs to understand the factors associated with aggression in inpatient units to prevent aggression.

AIM:
This study aimed to examine the level of aggression and its associated factors.

MATERIALS AND METHODS:
A descriptive observational design was conducted among aggressive patients. An aggressive behavior event was observed during the aggression episode. Data were collected from 55 patients with aggressive behavior using the Staff Observation Aggression Scale-Revised (SOAS-R) and Brief Psychiatric Rating Scale (BPRS). Patient-, staff-, and ward-related factors were assessed using a structured questionnaire.

RESULTS:
About 69% of patients had a severe level of aggressive behavior. There was a significant association between gender, the severity of symptoms, staff-to-patient ratio, ward milieu, and the number of caregivers with levels of aggression.

CONCLUSION:
The majority of the persons with mental illness exhibited severe aggression in a psychiatric setting. Being male, the presence of psychotic symptoms, ward milieu, staff-to-patient ratio, and availability of caregivers were significantly associated with aggression. This study adds to the existing literature by focusing on managing ward-related factors (avoiding noise and overcrowding) to prevent aggressive behavior among mentally ill patients.
The relation between alexithymia, eating attitude, and sleep pattern among university students during the lockdown period of COVID-19 pandemic
Authors: Rizvi Moattar Raza , Sharma Mahak , Sanghi Divya , Sharma Ankita , Saraswat Shubra , Saini Preeti , Kumari Sunita 
Published: August 2023

Background:
COVID-19 lockdown's impact on physical and mental health includes increased prevalence of alexithymia (difficulty recognizing emotions) among university students. Alexithymia is strongly correlated with eating disorders and disrupted eating behaviors. Understanding these associations is crucial for assessing the well-being of students during lockdown.

Aims:
The aim was to evaluate the prevalence of alexithymia and eating disorders in relation to sleep disturbance during this lockdown phase amongst university students.

Settings and Design:
This study employed an online cross-sectional design to collect data from participants. The study included adolescents of either gender, aged between 20 and 27 years, who were enrolled in the faculty of Allied Health Sciences at Manav Rachna International Institute of Research & Studies.

Methods and Material:
The study comprised 419 university students during the COVID-19 lockdown. Alexithymia was assessed using the Toronto Alexithymia Scale-20, eating disorders with the Eating Aptitude Test-26, and sleep patterns with a modified Pittsburgh Sleep Scale.

Statistical Analysis Used:
Descriptive statistics, including Mean±SD for continuous variables and frequency/percentages for categorical data, were calculated. Statistical analysis involved Student t-test and chi-square. Reliability of the questionnaire was assessed using Cronbach's Alpha.

Results:
This study involved 77.8% (n=326) female students as compared to 22.2%(n=93) male students. The prevalence of alexithymia was found to be considerably higher(30.5%) in the present study, with female students more affected than males. An eating disorder was found to be only 16.7%, and the majority of students (65.4%) had BMI in the range of normal weight. Further, the students reported the absence of sleep apnea with 41% of students having a sleep duration of 6-7 hours and 32% more than 7 hours. Only 19% of students reported poor sleep quality. Trouble sleeping during the initial 30 minutes prior to lying down, waking up in the middle of the night, and waking up to use the bathroom were the main factors causing sleep disturbances.

Conclusions:
This study reported a high alexithymia prevalence since there were under house arrest and going through psychological stress during lockdown phase of COVID-19 pandemic. Eating disorders was not prevalent because the students ate healthy balanced diets at home rather than junk food. Sleep patterns were also significantly improved and did not show any relation to the increased prevalence of alexithymia.