bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Snobbery
Authors: Johnson King Zoë A 
Published: March 2023

Abstract
This is a paper about the nature of snobbery and the undermining import of a charge of snobbery. On my account, snobs sincerely attempt to identify and correctly evaluate the aesthetically relevant features of an object, but they get things wrong, and their getting things wrong is explained by the fact that they under-value that which they associate with being lower-class. We can see the need for this account by reflecting on examples, and can distinguish it from existing accounts of snobbery by thinking about when and why evidence of snobbery constitutes higher-order evidence against one’s aesthetic judgements. Existing accounts either are consistent with snobs’ aesthetic judgements being flawless, and thus not undermined by evidence of snobbery, or they imply that the canonical reasoning-process for arriving at aesthetic judgements has been bypassed altogether. On my account, by contrast, snobbery does not bypass the canonical aesthetic reasoning-process but distorts it in systematic and predictable ways.
Postmortem Histopathologic Findings and SARS-CoV-2 Detection in Autopsy Kidneys of Patients With COVID-19: A Systematic Review and Meta-Analysis
Authors: Mahjani Mahsa , Parvin Mahmoud , Ghobadi Saeed , Jafari Alireza , Ahangar Hassan , Gohari Sheida , Gohari Sepehr 
Published: March 2023

Abstract

Objectives
This systematic review and meta-analysis aimed to investigate the prevalence of postmortem kidney histopathologic features of patients with coronavirus disease 2019 (COVID-19) in addition to the rate of renal tropism in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods
We searched Web of Science, PubMed, Embase, and Scopus up to September 2022 to identify eligible studies. A random-effects model was used to estimate the pooled prevalence. Cochran Q test and Higgins I2 were used to assess evidence of heterogeneity.

Results
In total, 39 studies were included in the systematic review. The meta-analysis included 35 studies consisting of a total of 954 patients, with an average age of 67.1 years. The pooled prevalence of acute tubular injury (ATI)–related changes was the predominant finding (85% [95% confidence interval, 71%-95%]), followed by arteriosclerosis (80%), vascular congestion (66%), and glomerulosclerosis (40%). Endotheliitis (7%), fibrin microthrombi (12%), focal segmental glomerulosclerosis (1%), and calcium crystal deposits (1%) were seen in a smaller number of autopsies. The overall average rate of virus detection was 47.79% in the pooled data of 21 studies (272 samples).

Conclusions
The main finding—ATI—correlated to clinical COVID-19–associated acute kidney injury. The presence of SARS-CoV-2 in kidney samples in addition to vascular lesions in kidneys can be linked to direct kidney invasion by the virus.
Workplace Exposure Measurements of Emission from Industrial 3D Printing
Authors: Kangas Anneli , Kukko Kirsi , Kanerva Tomi , Säämänen Arto , Akmal Jan Sher , Partanen Jouni , Viitanen Anna-Kaisa 
Published: March 2023

AbstractParticle and gaseous contaminants from industrial scale additive manufacturing (AM) machines were studied in three different work environments. Workplaces utilized powder bed fusion, material extrusion, and binder jetting techniques with metal and polymer powders, polymer filaments, and gypsum powder, respectively. The AM processes were studied from operator’s point of view to identify exposure events and possible safety risks. Total number of particle concentrations were measured in the range of 10 nm to 300 nm from operator’s breathing zone using portable devices and in the range of 2.5 nm to 10 µm from close vicinity of the AM machines using stationary measurement devices. Gas-phase compounds were measured with photoionization, electrochemical sensors, and an active air sampling method which were eventually followed by laboratory analyses. The duration of the measurements varied from 3 to 5 days during which the manufacturing processes were practically continuous. We identified several work phases in which an operator can potentially be exposed by inhalation (pulmonary exposure) to airborne emissions. A skin exposure was also identified as a potential risk factor based on the observations made on work tasks related to the AM process. The results confirmed that nanosized particles were present in the breathing air of the workspace when the ventilation of the AM machine was inadequate. Metal powders were not measured from the workstation air thanks to the closed system and suitable risk control procedures. Still, handling of metal powders and AM materials that can act as skin irritants such as epoxy resins were found to pose a potential risk for workers. This emphasizes the importance of appropriate control measures for ventilation and material handling that should be addressed in AM operations and environment.
Informant Characteristics Influence Reports of Participant Functioning and their Associations with Neuropsychological Performance in Non-Hispanic Black Adults
Authors: Graves Lisa V , Hamill Sharon , Larry Maiya , Williams Destiny 
Published: March 2023

Abstract

Objective
Assessing one’s functional capacity—in addition to neuropsychological performance—is essential for determining neurocognitive status, and functional assessment is often provided via informant report. Although informant characteristics have been shown to influence reports of participant functioning, the degree to which they moderate relationships between reported functioning and participant performance on neuropsychological testing is unclear. Moreover, associations among informant characteristics, reported functioning, and neuropsychological performance have not been adequately examined with non-Hispanic Black (NHB) samples, despite this population’s disproportionately high risk of Alzheimer’s disease and related dementias.

Method
In this cross-sectional observational study, we examined the influence of informant characteristics on informant reports of participant functioning (assessed via the Functional Activities Questionnaire [FAQ]) and associations between reported functioning and participant performance on neuropsychological testing, among NHB adult participants in the National Alzheimer’s Coordinating Center cohort (n = 1024).

Results
Informants who were younger, female, more educated, knew participants longer, or lived with participants reported poorer participant functioning (p &lt; .001). However, younger (vs. older) informants provided reports of functioning that were more predictive of visuoconstructional ability and visual memory, and male (vs. female) informants provided reports of functioning that were more predictive of verbal memory, visuoconstructional ability and visual memory, and language (ps &lt; .001).

Conclusions
Within the context of neurocognitive evaluations of NHB participants, informant characteristics may influence subjective reports of participants’ functioning and the extent to which reported functioning corroborates objective participant performance on neuropsychological testing.
Lesion Shedding Model: unraveling site-specific contributions to ctDNA
Authors: Rhrissorrakrai Kahn , Utro Filippo , Levovitz Chaya , Parida Laxmi 
Published: March 2023

AbstractSampling circulating tumor DNA (ctDNA) using liquid biopsies offers clinically important benefits for monitoring cancer progression. A single ctDNA sample represents a mixture of shed tumor DNA from all known and unknown lesions within a patient. Although shedding levels have been suggested to hold the key to identifying targetable lesions and uncovering treatment resistance mechanisms, the amount of DNA shed by any one specific lesion is still not well characterized. We designed the Lesion Shedding Model (LSM) to order lesions from the strongest to the poorest shedding for a given patient. By characterizing the lesion-specific ctDNA shedding levels, we can better understand the mechanisms of shedding and more accurately interpret ctDNA assays to improve their clinical impact. We verified the accuracy of the LSM under controlled conditions using a simulation approach as well as testing the model on three cancer patients. The LSM obtained an accurate partial order of the lesions according to their assigned shedding levels in simulations and its accuracy in identifying the top shedding lesion was not significantly impacted by number of lesions. Applying LSM to three cancer patients, we found that indeed there were lesions that consistently shed more than others into the patients’ blood. In two of the patients, the top shedding lesion was one of the only clinically progressing lesions at the time of biopsy suggesting a connection between high ctDNA shedding and clinical progression. The LSM provides a much needed framework with which to understand ctDNA shedding and to accelerate discovery of ctDNA biomarkers. The LSM source code has been available in the IBM BioMedSciAI Github (https://github.com/BiomedSciAI/Geno4SD).
Auto-Kla: a novel web server to discriminate lysine lactylation sites using automated machine learning
Authors: Lai Fei-Liao , Gao Feng 
Published: March 2023

AbstractRecently, lysine lactylation (Kla), a novel post-translational modification (PTM), which can be stimulated by lactate, has been found to regulate gene expression and life activities. Therefore, it is imperative to accurately identify Kla sites. Currently, mass spectrometry is the fundamental method for identifying PTM sites. However, it is expensive and time-consuming to achieve this through experiments alone. Herein, we proposed a novel computational model, Auto-Kla, to quickly and accurately predict Kla sites in gastric cancer cells based on automated machine learning (AutoML). With stable and reliable performance, our model outperforms the recently published model in the 10-fold cross-validation. To investigate the generalizability and transferability of our approach, we evaluated the performance of our models trained on two other widely studied types of PTM, including phosphorylation sites in host cells infected with SARS-CoV-2 and lysine crotonylation sites in HeLa cells. The results show that our models achieve comparable or better performance than current outstanding models. We believe that this method will become a useful analytical tool for PTM prediction and provide a reference for the future development of related models. The web server and source code are available at http://tubic.org/Kla and https://github.com/tubic/Auto-Kla, respectively.
Latitudinal gradients in the skull shape and assemblage structure of delphinoid cetaceans
Authors: McCurry Matthew R , Park Travis , Coombs Ellen J , Hart Lachlan J , Laffan Shawn 
Published: March 2023

AbstractWithin delphinoid cetaceans, snout shape is significantly correlated to diet, with long-snouted raptorial-feeding predators preying on smaller and more agile prey than shorter-snouted species. Although there have been several studies into longirostry from a functional perspective there have been no quantitative analyses of spatial variation in skull shape or how the pattern in skull shape morphospace occupation varies between assemblages. Here we analyse the cranial morphological variation of Delphinoidea assemblages. Firstly, we calculate mean and Gi* hotspot statistics of skull shape across the world’s oceans. We find that tropical and subtropical assemblages exhibit higher average measures of longirostry. This pattern is likely caused by differences in the availability of certain prey types in warmer and cooler environments. Secondly, we calculate mean pairwise distance as well as mean nearest taxon distance in functional traits between the members of 119 unique delphinoid assemblages. There was a trend for low latitude assemblages to exhibit greater overdispersion in PC1 (snout length) compared those from high latitudes. Our results suggest that ocean temperature is influential in determining the diversity, range limits and assemblage structure of delphinoid cetaceans.
Strategic Information: A Qualitative Study on the Use of Digital Curriculum Vitae for Social Work with Vulnerable Clients
Authors: Schmidt Alexandrina 
Published: March 2023

Abstract
This study investigates the use of the digital curriculum vitae (CV), a digital information system, in social work with vulnerable clients. The investigation takes the constructionist grounded theory approach to examine twenty-one open-ended qualitative interviews with social workers in Danish job centres. Social workers use digital CVs in three ways. First, they collect detailed information about their clients through a digital CV, which tests their vulnerable positions. Second, social workers can use the information collected in the digital CV to reveal skills and resources that clients do not value and rework the attitudes of clients towards the labour market. Third, social workers who work with the most vulnerable clients avoid and adapt digital CV usage to benefit their clients and thus resist prescribed procedures. Overall, the use of digital CVs depends on the perceived vulnerability of the clients. The current study shows that social workers collect and strategically employ digitally stored information to help their clients. Hence, they may risk overlooking the complexity of social issues or compromising the transparency of social work. The study demonstrates that the digitalisation of public service makes social work strategic in response to socially and technologically constraining welfare situations.
Downregulation of MALAT1 is a hallmark of tissue and peripheral proliferative T cells in COVID-19
Authors: Dey Shoumit , Ashwin Helen , Milross Luke , Hunter Bethany , Majo Joaquim , Filby Andrew J , Fisher Andrew J , Kaye Paul M , Lagos Dimitris 
Published: March 2023

Abstract
T cells play key protective but also pathogenic roles in COVID-19. We studied the expression of long non-coding RNAs (lncRNAs) in COVID-19 T-cell transcriptomes by integrating previously published single-cell RNA sequencing datasets. The long intergenic non-coding RNA MALAT1 was the most highly transcribed lncRNA in T cells, with Th1 cells demonstrating the lowest and CD8+ resident memory cells the highest MALAT1 expression, amongst CD4+ and CD8+ T-cells populations, respectively. We then identified gene signatures that covaried with MALAT1 in single T cells. A significantly higher number of transcripts correlated negatively with MALAT1 than those that correlated. Enriched functional annotations of the MALAT1- anti-correlating gene signature included processes associated with T-cell activation such as cell division, oxidative phosphorylation, and response to cytokine. The MALAT1 anti-correlating gene signature shared by both CD4+ and CD8+ T-cells marked dividing T cells in both the lung and blood of COVID-19 patients. Focussing on the tissue, we used an independent patient cohort of post-mortem COVID-19 lung samples and demonstrated that MALAT1 suppression was indeed a marker of MKI67+ proliferating CD8+ T cells. Our results reveal MALAT1 suppression and its associated gene signature are a hallmark of human proliferating T cells.
The Time for Action Is Now: The Impact of Timing of Infectious Disease Consultation for Staphylococcus aureus Bacteremia
Authors: Cole J Chase , Jankowski Christopher A , Verdecia Jorge L , Isache Carmen L , Ravi Malleswari S , McCarter Yvette S , Casapao Anthony M 
Published: March 2023

Abstract
This retrospective cohort study was performed to compare clinical outcomes between patients with Staphylococcus aureus bacteremia who received an early versus late infectious disease consultation. Early consultation resulted in significantly greater adherence to quality care indicators and shorter hospital stays.
Risk Factors, Temporal Dependence, and Seasonality of Human Extended-Spectrum β-Lactamases-Producing Escherichia coli and Klebsiella pneumoniae Colonization in Malawi: A Longitudinal Model-Based Approach
Authors: Sammarro Melodie , Rowlingson Barry , Cocker Derek , Chidziwisano Kondwani , Jacob Shevin T , Kajumbula Henry , Mugisha Lawrence , Musoke David , Lester Rebecca , Morse Tracy , Feasey Nicholas , Jewell Chris 
Published: March 2023

Abstract

Background
Sub-Saharan Africa has the highest estimated death rate attributable to antimicrobial resistance, especially from extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E). However, the dynamics of human colonization in the community with ESBL-E are not well described. Inadequate water, sanitation, and hygiene infrastructure and associated behaviors are believed to play an important role in transmission of ESBL-E, and an improved understanding of the temporal dynamics of within-household transmission could help inform the design of future policies.

Methods
In this 18-month study, using microbiological data and household surveys, we built a multivariable hierarchical harmonic logistic regression model to identify risk factors for colonization with ESBL-producing Escherichia coli and Klebsiella pneumoniae, reflecting household structure and temporal correlation of colonization status.

Results
Being male was associated with a lower risk of colonization with ESBL-producing E. coli (odds ratio [OR], 0.786; credible interval [CrI], .678–.910), whereas the use of a tube well or a borehole was associated with an increased risk (OR, 1.550; CrI, 1.003–2.394). For ESBL-producing K. pneumoniae, recent antibiotic exposure increased risk of colonization (OR, 1.281; CrI, 1.049–1.565), whereas sharing plates decreased that risk (OR, 0.672; CrI, .460–.980). Finally, the temporal correlation range of 8 to 11 weeks provided evidence that within-household transmission occurs within this time frame.

Conclusions
We describe different risks for colonization with different enteric bacterial species. Our findings suggest interventions to reduce transmission targeted at the household level need to focus on improving water, sanitation, and hygiene infrastructure and associated behaviors, whereas at the community level, they should focus on both environmental hygiene and antibiotic stewardship.
Hepatitis C Virus Reinfection in a Real-World Cohort of Homeless-Experienced Individuals in Boston
Authors: Beiser Marguerite E , Shaw Leah C , Shores Savanna K , Carson Joanne M , Hajarizadeh Behzad 
Published: March 2023

Abstract

Background
People experiencing homelessness are disproportionately affected by hepatitis C virus (HCV) infection compared with housed populations. Surveillance for HCV reinfection after successful treatment is a critical step in the care cascade, but limited data on reinfection are available among this highly marginalized group. This study assessed posttreatment reinfection risk in a real-world cohort of homeless-experienced individuals in Boston.

Methods
Individuals receiving HCV direct-acting antiviral treatment through Boston Health Care for the Homeless Program during 2014–2020 with posttreatment follow-up assessment were included. Reinfection was identified based on recurrent HCV RNA at 12 weeks posttreatment with HCV genotype switch or any recurrent HCV RNA following sustain virologic response.

Results
A total of 535 individuals were included (81% male, median age 49 years, 70% unstably housed or homeless at treatment initiation). Seventy-four HCV reinfections were detected, including 5 second reinfections. HCV reinfection rate was 12.0/100 person-years (95% confidence interval [CI]: 9.5–15.1) overall, 18.9/100 person-years (95% CI: 13.3–26.7) among individuals with unstable housing and 14.6/100 person-years (95% CI: 10.0–21.3) among those experiencing homelessness. In adjusted analysis, experiencing homelessness (vs stable housing, adjusted hazard ratio, 2.14; 95% CI: 1.09–4.20; P = .026) and drug use within 6 months before treatment (adjusted hazard ratio, 5.23; 95% CI: 2.25–12.13; P &lt; .001) were associated with increased reinfection risk.

Conclusions
We found high HCV reinfection rates in a homeless-experienced population, with increased risk among those homeless at treatment. Tailored strategies to address the individual and systems factors impacting marginalized populations are required to prevent HCV reinfection and to enhance engagement in posttreatment HCV care.
Marx’s equalised rate of exploitation
Authors: Cogliano Jonathan F 
Published: March 2023

Abstract
Marx assumes a uniform rate of exploitation throughout Capital, yet the theoretical basis for this assumption and its role in his theory of value are not widely recognised in the existing literature. This article shows that Marx assumed a tendentially equalised rate of exploitation to be the outcome of labour mobility and that he viewed this as a general tendency of capitalist economies. Marx draws extensively on Adam Smith to support his views on labour mobility and the equalised rate of exploitation. The close connection between Smith and Marx on notions of labour mobility is examined here. Understanding the role of labour mobility and the equalised rate of exploitation in Marx’s work holds implications for contemporary approaches to classical-Marxian price and value theory and supports the view that Marx’s theory of value is, in the most general sense, a theory of the allocation of social labour.
Indigenous Medea: space, time, and resistance in Wesley Enoch’s Black Medea
Authors: Kearns Clare 
Published: March 2023

Abstract
In Wesley Enoch’s 2000 play Black Medea, Seneca’s Medea is reworked for settler-colonial Australia: Enoch’s Medea is an Indigenous woman from an unnamed Land who falls in love with Jason, an Indigenous man from the city with ambitions to succeed by settler-colonial standards. Against the will of her family, Medea reveals to Jason the natural resources lying underneath her Land and allows him to overturn the sacred earth in pursuit of profit for a Western corporation. The tragedy chronicles the subsequent demise of Jason and Medea’s relationship in the settler city and Medea’s filicidal retaliation for Jason’s crimes. Despite the radically different setting of Black Medea from its Roman antecedent, the two plays share numerous thematic concerns as well as several key moments in which the Senecan text is quoted verbatim. This essay contends that in Black Medea, Enoch apprehends topoi of displacement and temporal normativity from Seneca’s Medea and mobilizes them to elucidate the conditions of Indigenous Australians under settler colonialism. By doing so, he offers critical insight towards the use of Indigeneity as an analytic for Medea myths ancient and modern.
lncHUB2: aggregated and inferred knowledge about human and mouse lncRNAs
Authors: Marino Giacomo B , Wojciechowicz Megan L , Clarke Daniel J B , Kuleshov Maxim V , Xie Zhuorui , Jeon Minji , Lachmann Alexander , Ma’ayan Avi 
Published: March 2023

AbstractLong non-coding ribonucleic acids (lncRNAs) account for the largest group of non-coding RNAs. However, knowledge about their function and regulation is limited. lncHUB2 is a web server database that provides known and inferred knowledge about the function of 18 705 human and 11 274 mouse lncRNAs. lncHUB2 produces reports that contain the secondary structure fold of the lncRNA, related publications, the most correlated coding genes, the most correlated lncRNAs, a network that visualizes the most correlated genes, predicted mouse phenotypes, predicted membership in biological processes and pathways, predicted upstream transcription factor regulators, and predicted disease associations. In addition, the reports include subcellular localization information; expression across tissues, cell types, and cell lines, and predicted small molecules and CRISPR knockout (CRISPR-KO) genes prioritized based on their likelihood to up- or downregulate the expression of the lncRNA. Overall, lncHUB2 is a database with rich information about human and mouse lncRNAs and as such it can facilitate hypothesis generation for many future studies. The lncHUB2 database is available at https://maayanlab.cloud/lncHUB2.Database URL: https://maayanlab.cloud/lncHUB2