bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical, pathological, and radiological features of 80 pediatric diffuse intrinsic pontine gliomas: A single-institute study
Authors: Zhang Peng , Duan Yunyun , Gu Guocan , Qu Liying , Xiao Dan , Xi Tianshu , Pan Changcun , Liu Ya’ou , Zhang Liwei 
Published: February 2023

ObjectiveDiffuse intrinsic pontine gliomas (DIPGs) are rare but devastating diseases. This retrospective cross-sectional study aimed to investigate the clinical, radiological, and pathological features of DIPGs.Materials and methodsThe clinical data of 80 pediatric DIPGs under clinical treatment in Beijing Tiantan Hospital from July 2013 to July 2019 were retrospectively collected and studied. A follow-up evaluation was performed.ResultsThis study included 48 men and 32 women. The most common symptoms were cranial nerve palsy (50.0%, 40/80 patients) and limb weakness (41.2%, 33/80 patients). Among the 80 patients, 24 cases were clinically diagnosed, 56 cases were pathologically verified, and 45 cases were tested for H3K27 alteration status, with 34 H3K27 alteration cases confirmed. Radiological results indicated that enhancement was common (65.0%, 52/80 patients). Cho/Cr was of predictive value for H3K27 alteration status (P = 0.012, cutoff value = 2.38, AUC = 0.801). Open cranial surgery followed by further chemotherapy and radiotherapy was beneficial for patients’ overall survival. Cox regression analysis indicated H3K27 alteration to be the independent prognostic influencing factor for DIPGs in this series (P = 0.002).ConclusionDIPGs displayed a wide spectrum of clinical and imaging features. Surgery-suitable patients could benefit from postoperative comprehensive therapy for a better overall survival. H3K27 alteration was the independent prognostic influencing factor for DIPGs.
Latest evidence of microwave ablation for papillary thyroid microcarcinoma compared with surgery: A systematic review and meta-analysis
Authors: Feng Jie , Jiang Yizhou , Feng Yiyan 
Published: February 2023

BackgroundThe most typical thyroid gland malignant lesion is papillary thyroid cancer (PTC). In many nations, the prevalence of thyroid cancer (TC) is rising, particularly papillary thyroid microcarcinoma (PTMC). Microwave ablation (MWA) has been gradually carried out in some patients with benign thyroid nodules, some low-risk PTMC, and metastatic lymph nodes in the neck. The role and safety of MWA remain controversial topics. So we conducted this study to provide the latest evidence of MWA for PTMC compared with surgery.MethodsPatients’ postoperative outcomes (duration of hospital stay and hospitalization expenditures), intraoperative outcomes (surgery time, blood loss, and incision size), and follow-up outcomes were all examined (complication rate, recurrence rate, and lymph node metastasis). The effectiveness and safety of MWA versus surgery for PTMC patients were compared using the weighted mean difference (WMD) and odds ratio (OR).ResultsIn total, we included 7 articles (7 trial comparisons) which contained 1, 567 PTMC patients. The results showed that MWA had significant advantages in operative time (WMD = -53.47, 95% CI: -67.62 to -39.32), postoperative hospital stay (WMD =-4.59, 95% CI: -6.40 to -2.77), hospitalization costs (WMD= -70.06, 95% CI: -90.93 to -49.19), blood loss (WMD =-28.07, 95% CI: -33.77 to -22.38), incisions size (WMD =-59.69, 95% CI: -67.79 to -51.59), and complication rates (OR = 0.28; 95% CI: 0.18 to 0.42) compared with surgery. It also showed that recurrence rates and risk of lymph node metastasis are similar to surgery.ConclusionsFor PTMC patients, MWA could be an efficient, safe, and affordable therapy.
Genetic variants in the calcium signaling pathway participate in the pathogenesis of colorectal cancer through the tumor microenvironment
Authors: Wu Jing-Yu , Shao Yu , Huang Chang-Zhi , Wang Zhen-Ling , Zhang Hong-Qiang , Fu Zan 
Published: February 2023

BackgroundCancer risk is influenced by calcium signaling in intracellular and intercellular signaling pathways. However, the relationship between the calcium signaling pathway and colorectal cancer risk remains unknown. We aim to evaluate the role of genetic variants in calcium signaling pathway genes in colorectal cancer risk through the tumor microenvironment.MethodsAn analysis of genetic variants in the calcium signaling pathway was conducted using a case-control study that included 1150 colorectal cancer patients and 1342 non-cancer patients. Using the regression model, we assessed whether single-nucleotide polymorphisms (SNPs) increase the risk of colorectal cancer. We also performed a dual luciferase reporter gene assay using HCT116 cell lines and DLD1 cell lines to demonstrate the regulatory relationship between SNP and candidate risk gene. We evaluated the expression of candidate risk gene in different populations. In addition, we also evaluated candidate risk gene and 22 immune cells correlation studies.ResultsThere was a significant association between the PDE1C rs12538364 T allele and colorectal cancer risk [odds ratio (OR) = 1.57, 95% confidence interval (CI) = 1.30 – 1.90, P = 3.07 × 10–6, PFDR = 0.004]. Mutation of intron region rs1538364 C to T locus reduces promoter activity of PDE1C in DLD1 and HCT116 cell lines (P &lt; 0.05). We identified that PDE1C is significantly down-regulated in colorectal cancer, closely associated with 22 immune cells. Finally, we found that PDE1C could be the biomarker for individual immunotherapy of colorectal cancer.ConclusionAccording to our findings, PDE1C may be a key factor contributing to colorectal cancer, thus improving individual immunotherapy for the disease. The potential mechanism by which polymorphisms in the calcium signaling pathway genes may participate in the pathogenesis of colorectal cancer through the tumor microenvironment.
The effectiveness of repeated sucrose for procedural pain in neonates in a longitudinal observational study
Authors: Bueno Mariana , Ballantyne Marilyn , Campbell-Yeo Marsha , Estabrooks Carole A. , Gibbins Sharyn , Harrison Denise , McNair Carol , Riahi Shirine , Squires Janet , Synnes Anne , Taddio Anna , Victor Charles , Yamada Janet , Stevens Bonnie 
Published: February 2023

GoalTo determine the analgesic effectiveness of repeated sucrose administration for skin-breaking (SB) procedures over the Neonatal Intensive Care Unit (NICU) hospitalization of preterm infants.MethodsLongitudinal observational study, conducted in four level III Canadian NICUs. Eligible infants were &lt;32 weeks gestational age at birth, and &lt;10 days of life at enrollment. Infants received 24% sucrose (0.12 ml) prior to all painful procedures. The Premature Infant Pain Profile – Revised (PIPP-R) was used at 30 and 60 seconds after a medically-required SB procedure as soon as possible after enrollment and weekly up to three additional times for scheduled procedures.Results172 infants (57.3% male, gestational age 28.35 (±2.31) weeks) were included. The mean 30 s PIPP-R scores were 6.11 (±3.68), 5.76 (±3.41), 6.48 (±3.67), and 6.81 (±3.69) respectively; there were no statistically significant interactions of study site by time (p = 0.31) or over time (p = 0.15). At 60 s, mean PIPP-R scores were 6.05 (±4.09), 5.74 (±3.67), 6.19 (±3.7), and 5.99 (±3.76) respectively; there were no study site by time interactions (p = 0.14) or differences over time (p = 0.52). There was a statistically significant site difference in the effectiveness of sucrose at 30 and 60 seconds (p &lt; 0.01).ConclusionsConsistently low PIPP-R scores following a skin-breaking procedure indicated that the analgesic effectiveness of the minimal dose of sucrose was sustained over time in the NICU. Further research is required to determine the optimal combination of sucrose and other pain management strategies to improve clinical practice and the impact of consistent use of repeated use of sucrose on neurodevelopment.
Effects of psychosocial function in pediatric-onset inflammatory bowel disease during the coronavirus disease 2019 pandemic
Authors: Zhang Huihui , Yang Yun , Zhao Xixi , Hu Huajian , Liu Jia , Zhan Xue , Song Xiaomei , Guo Hong , Li Zhongyue , Zhou Xiaoqin 
Published: February 2023

Background and AimsResearch on the effect of the coronavirus disease 2019 (COVID-19) pandemic on psychosocial function in patients with pediatric-onset inflammatory bowel disease (PIBD) is limited. This study aimed to evaluate the psychological status of patients with PIBD before and during the pandemic, and the relationship between mental health and disease activity.MethodsThis study was a retrospective cohort study. Statistical analyses were performed to assess the relationship between demographic, clinical data and psychological data (questionnaires) of PIBD patients before and during the epidemic. The anxiety and depression emotional status of the guardians during the pandemic were evaluated.ResultsIn the PIBD follow-up cohort, 42 patients(male 61.9%) were included. Female with PIBD had lower pediatric quality of life inventory(PedsQL) scores (P = 0.007) and higher spence children's anxiety scale(SCAS) scores (P = 0.038) than male. The pandemic did not have a substantial impact on PedsQL, pittsburgh sleep quality index(PSQI), SCAS, or children's depression inventory(CDI) in patients with PIBD. The self-rating anxiety scale(SAS) score, anxiety rate, self-rating depression scale(SDS) score, and depression rate of PIBD guardians were significantly higher than those of healthy controls (SAS, P = 0.008; SDS, P = 0.001).ConclusionsFemale children with PIBD were more vulnerable to decreased QOL and increased anxiety than male children. The anxiety and depression status of PIBD guardians were significantly higher than those of healthy controls during the COVID-19 pandemic. But the COVID-19 pandemic did not significantly affect quality of life(QOL), sleep, anxiety, or depressive mood of patients with PIBD in our study.
Towards the ideal vascular implant: Use of machine learning and statistical approaches to optimise manufacturing parameters
Authors: Roldán Elisa , Reeves Neil D. , Cooper Glen , Andrews Kirstie 
Published: February 2023

Introduction: Electrospinning is a manufacturing technique that creates a net of nano and microfibres able to mimic the natural extracellular matrix (ECM) of biological tissue. Electrospun scaffolds' morphology and mechanical behaviour can be tailored by modifying the environmental, solution and process parameters. This study aims to produce biomimetic vascular implants optimising the manufacturing set up through two machine learning techniques and statistical approaches.Methods: Polyvinyl alcohol (PVA) based scaffolds were produced by modifying the concentration of the polymer, flow rate, voltage, type of collector, diameter of the needle, distance between needle and collector and revolutions of the mandrel. The scaffolds were morphologically and mechanically characterised using scanning electron microscopy and mechanical testing respectively to inform the morphological model (simultaneously predicting diameter of the fibres and inter-fibre separation) and mechanical model (predicting strain at rupture and ultimate tensile strength).Results: Prediction and traditional techniques led to an optimum set up of: 12% PVA, 1 ml/h flow rate, 20 kV, 8 cm between the needle, 18 G gauge needle, rotational mandrel of 15 cm and 2000 rpm. Optimised PVA scaffolds replicated the mechanical properties and morphology of the vascular tissue with an ultimate tensile strength of 6.17 ± 0.18 MPa, a strain at break of 97.39 ± 5.06, fibre diameters of 126 ± 6.11 nm and inter-fibre separation of 1488 ± 91.99 nm.Discussion: This work revealed for the first time that machine learning Chi-squared Automatic Interaction Detection (CHAID) models are a novel and visual route to elect the optimum manufacturing set up to develop biomimetic vascular implants. Novel two-output Artificial Neural Networks (ANN) and multivariate analysis of variance and covariance (MANOVA, MANCOVA) models presented comparable prediction results (R2=0.91); however, two-output ANN predicted models demonstrated to be the most powerful tool for non-parametric conditions, showing cross-validation mean squared errors (MSE) of 0.0001943. Multi Linear Regression models (MLR) exhibited the lowest accuracy in their predictions (R2=0.6). Machine learning, statistical approaches and traditional characterisation methods were studied to successfully achieve vascular substitutes with analogous biomechanical behaviour and physical structure to the native vascular tissue.
Associations of serum 25(OH)D levels with physical performance and anabolic hormones in young men
Authors: Laaksi Akseli , Laaksi Ilkka , Pihlajamäki Harri , Vaara Jani P. , Luukkaala Tiina , Kyröläinen Heikki 
Published: February 2023

Purpose: The present study examined the association of vitamin D measured by serum 25(OH)D with physical performance outcomes and serum levels of anabolic hormones in young men.Methods: 412 young men (age 19 ± 1 year) entering their compulsory military service volunteered to participate in the study. The study consisted of two groups from two different military bases: Group A was studied in January and group B in July. The groups were first compared with each other and due to statistically significant (p &lt; 0.001 analyzed with independent samples t-test) differences in physical condition (sit-up, push-up, and standing long jump-tests and testosterone levels) between the groups, groups were analyzed separately. The serum levels of 25(OH)D, testosterone (TES), sex hormone binding globulin (SHBG), and insulin-like growth factor-1 (IGF-1) were analyzed by electrochemiluminescence immunoassay. Physical performance tests consisted of muscular fitness (sit-ups, push-ups, standing long jump) and aerobic fitness (12-minute-running) tests. The association of serum 25(OH)D with physical performance tests and anabolic hormones was analyzed using linear regression.Results: After controlling for the group, body mass index, and leisure-time physical activity, serum 25(OH)D level was positively associated with aerobic and muscular fitness (β = 0.15–0.20, all p &lt; 0.05). Also, the participants with sufficient serum 25(OH)D levels (≥75 nmol/L) had better aerobic and muscular fitness and higher TES in group B, and better upper extremity muscular fitness in group A (all p &lt; 0.05). In group A, there were 166 participants with serum levels of 25(OH) D &lt; 75 nmol/L and 18 ≥ 75 nmol/L. In group B, the amounts were 92 (&lt;75 nmol/L) and 136 (≥75 nmol/L), respectively.Conclusion: Serum 25(OH)D was positively associated with both aerobic and muscular fitness and those with sufficient vitamin D levels, had higher levels of TES. Thus, maintaining a sufficient serum 25(OH)D level may be beneficial for physical performance and anabolic state in young men.
Preventing, reducing, and attenuating restraint: A prospective controlled trial of the implementation of peer support in acute psychiatry
Authors: Badouin Julia , Bechdolf Andreas , Bermpohl Felix , Baumgardt Johanna , Weinmann Stefan 
Published: February 2023

IntroductionThe use of restraint as a means of managing patients is considered a critical factor that interferes with recovery. Strategies to create a less restrictive environment within psychiatric facilities are therefore eagerly sought. Peer support workers (PSWs) are increasingly employed in mental health settings. The prevailing theory is that PSWs have the potential to contribute to conflict and restraint prevention efforts in acute psychiatric wards. However, to date, research in support of this claim remains limited.ObjectiveThe present study aimed at assessing the effectiveness of employing peer support workers with regard to reducing the use of restraint.MethodsThis prospective controlled pre–post study sought to evaluate the implementation of peer support in one locked ward compared to treatment as usual (TAU) with no implementation of peer support in a second locked ward of a psychiatry department in Berlin, Germany. The pre–post comparison was planned to consist of two assessment periods of 3 months each, taking place directly before and after peer support implementation or TAU. Both assessments were extended to a period of 6 months, before and after the initially planned 12-month implementation process, in order to balance the effects of disruptions and of the COVID-19 pandemic. Using routine data, the proportion, frequency, and duration of mechanical restraint, forced medication as well as mechanical restraint in combination with forced medication, were evaluated.ResultsIn the control group, an increase in the proportion of patients subjected to measures of restraint was found between pre- and post-assessment, which was accompanied by a further increase in the mean number of events of restraint per patient within this group. In the intervention group, no significant change in the application of restraint was observed during the study period.DiscussionThere is some indication that peer support may be protective with regard to restraint in acute wards. However, our study faced major challenges during the implementation process and the post-assessment period, such as COVID-19 and staff reorganization. This may have led to peer support not reaching its full potential. The relationship between the implementation of peer support and the use of restraint therefore merits further investigation.
Same label, different patients: Health-workers’ understanding of the label ‘critical illness’
Authors: Mkumbo Elibariki , Willows Tamara Mulenga , Onyango Onesmus , Khalid Karima , Maiba John , Schell Carl Otto , Oliwa Jacquie , McKnight Jacob , Baker Tim 
Published: February 2023

BackgroundDuring the course of patients’ sickness, some become critically ill, and identifying them is the first important step to be able to manage the illness. During the course of care provision, health workers sometimes use the term ‘critical illness’ as a label when referring to their patient's condition, and the label is then used as a basis for communication and care provision. Their understanding of this label will therefore have a profound impact on the identification and management of patients. This study aimed to determine how Kenyan and Tanzanian health workers understand the label ‘critical illness’.MethodsA total of 10 hospitals—five in Kenya and five in Tanzania—were visited. In-depth interviews were conducted with 30 nurses and physicians from different departments in the hospitals who had experience in providing care for sick patients. We conducted a thematic analysis of the translated and transcribed interviews, synthesized findings and developed an overarching set of themes which captured healthcare workers’ understandings of the label ‘critical illness’.ResultsOverall, there does not appear to be a unified understanding of the label ‘critical illness’ among health workers. Health workers understand the label to refer to patients in four thematic ways: (1) those in a life-threatening state; (2) those with certain diagnoses; (3) those receiving care in certain locations; and (4) those in need of a certain level of care.ConclusionThere is a lack of a unified understanding about the label ‘critical illness’ among health workers in Tanzania and Kenya. This potentially hampers communication and the selection of patients for urgent life-saving care. A recently proposed definition, “a state of ill health with vital organ dysfunction, a high risk of imminent death if care is not provided and the potential for reversibility”, could be useful for improving communication and care.
A bioinspired stiffness tunable sucker for passive adaptation and firm attachment to angular substrates
Authors: Goshtasbi Arman , Sadeghi Ali 
Published: February 2023

The ability to adapt and conform to angular and uneven surfaces improves the suction cup’s performance in grasping and manipulation. However, in most cases, the adaptation costs lack of required stiffness for manipulation after surface attachment; thus, the ideal scenario is to have compliance during adaptation and stiffness after attachment to the surface. Inspired by the capability of stiffness regulation in octopus suction cup, this article presents a suction cup that adapts to steep angular surfaces due to compliance and has high stiffness after attachment. In this design, the stiffness after attachment is provided by using granular jamming as vacuum driven stiffness modulation. Thus, the design is composed of a conventional active suction pad connected to a granular stalk, emulating a hinge behavior during adaptation and creating high stiffness by jamming granular particles driven by the same vacuum as the suction pad. During the experiment, the suction cup can adapt to angles up to 85° with a force lower than 0.5 N. We also investigated the effect of granular stalk’s length on the adaptation and how this design performs compared to passive adaptation without stiffness modulation.
Exploring barriers and perceptions to walking and cycling in Nairobi metropolitan area
Authors: Basil Paschalin , Nyachieo Gladys 
Published: February 2023

IntroductionWalking and cycling as a form of active travel offer an opportunity for individuals to engage in physical exercises while performing a functional journey. Notwithstanding, the large proportion of the population relying on non-motorized transport (NMT), namely walking and cycling, has not been prioritized. At a time when lifestyle health challenges such as obesity and other non-communicable diseases are on the rise, walking and cycling would provide a window of opportunity and potentially provide exercise and thus improve the general health and wellbeing of the population. More than 75% of total daily trips made by Africa's low-income population are made by walking, compared with 45% by the more affluent people. Walking and cycling, considered low-carbon emission modes of transport, not only enhance urban quality but also boost social cohesion. Despite these potential gains, poor NMT infrastructure systems, low integration with the other modes of transport, and non-committal by law enforcement to protect pedestrians and cyclists still define the NMT ecosystem.MethodsThis study used descriptive methods to explore the barriers to and citizen perceptions of walking and cycling in Kenya's capital, the Nairobi Metropolitan area.Results and discussionPoor or absence of proper NMT infrastructure systems, safety concerns due to poor planning, lack of targeted policies as well as low or no capacity to ride a bicycle are among the predominant factors that undermine the use of NMT in Nairobi. However, a majority of citizens find no positive link between walking and/or cycling and poverty, a significant deviation from some prior studies and report.RecommendationsOther than scaling up walking and cycling facilities, this study strongly recommends the use of participatory city frameworks to support NMT research, transport policy, and the needs of those already using walking and cycling as active modes of transport.