bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Need for Preoperative MRI Before Primary Hip Arthroscopy in Patients 40 Years and Younger With Femoroacetabular Impingement Syndrome: A Multicenter Comparative Analysis
Authors: Ramkumar Prem N. , Berrier Ava S. , Helm J. Matthew , Koolmees Dylan S. , Pareek Ayoosh , Krych Aaron J. , Makhni Eric C. , Harris Joshua D. , Nwachukwu Benedict U. 
Published: January 2023

Background: Routine hip magnetic resonance imaging (MRI) before arthroscopy for patients with femoroacetabular impingement syndrome (FAIS) offers questionable clinical benefit, delays surgery, and wastes resources. Purpose: To assess the clinical utility of preoperative hip MRI for patients aged ≤40 years who were undergoing primary hip arthroscopy and who had a history, physical examination findings, and radiographs concordant with FAIS. Study Design: Cohort study; Level of evidence, 3. Methods: Included were 1391 patients (mean age, 25.8 years; 63% female; mean body mass index, 25.6) who underwent hip arthroscopy between August 2015 and December 2021 by 1 of 4 fellowship-trained hip surgeons from 4 referral centers. Inclusion criteria were FAIS, primary surgery, and age ≤40 years. Exclusion criteria were MRI contraindication, reattempt of nonoperative management, and concomitant periacetabular osteotomy. Patients were stratified into those who were evaluated with preoperative MRI versus those without MRI. Those without MRI received an MRI before surgery without deviation from the established surgical plan. All preoperative MRI scans were compared with the office evaluation and intraoperative findings to assess agreement. Time from office to arthroscopy and/or MRI was recorded. MRI costs were calculated. Results: Of the study patients, 322 were not evaluated with MRI and 1069 were. MRI did not alter surgical or interoperative plans. Both groups had MRI findings demonstrating anterosuperior labral tears treated intraoperatively (99.8% repair, 0.2% debridement, and 0% reconstruction). Compared with patients who were evaluated with MRI and waited 63.0 ± 34.6 days, patients who were not evaluated with MRI underwent surgery 6.5 ± 18.7 days after preoperative MRI. MRI delayed surgery by 24.0 ± 5.3 days and cost a mean $2262 per patient. Conclusion: Preoperative MRI did not alter indications for primary hip arthroscopy in patients aged ≤40 years with a history, physical examination findings, and radiographs concordant with FAIS. Rather, MRI delayed surgery and wasted resources. Routine hip MRI acquisition for the younger population with primary FAIS with a typical presentation should be challenged.
rTSA With Humeral Head Autograft Glenoid Reconstruction
Authors: Sabzevari Soheil , Eads Ryan , Charles Shaquille , Reddy Rajiv P. , Lin Albert 
Published: January 2023

Background: Untreated chronic massive rotator cuff tears and primary osteoarthritis can lead to conditions of significant retroversion, posterior bone loss, and humeral head subluxation. Indications: Reverse total shoulder arthroplasty with humeral head autograft glenoid reconstruction may be indicated in patients with advanced glenohumeral osteoarthritis and/or severe glenoid retroversion/bone loss due to rotator cuff arthropathy, trauma, primary, or inflammatory osteoarthritis. Technique: Besides routine radiography and preoperative computed tomography (CT) scans, 3-dimensional (3D) planning software is often performed as a routine part of preoperative planning. A 3D printed model of the glenoid can also be helpful in cases of significant bone deformity. Patients are placed in a 45° modified beach chair position. Using a standard deltopectoral approach, the glenoid is exposed. An anatomic humeral head resection is made. The contour of the articular margin of the humeral head should match the glenoid bone deficiency anatomically as it has been chronically resting within the glenoid defect. Three dimensional preoperative planning and the 3D printed model are used to make an asymmetric humeral head autograft which should match the deficiency perfectly. The articular cartilage is removed with a burr. The graft and baseplate are coupled together (metaphyseal bone facing the baseplate and prepared articular side of the graft facing native bone) and measurements are performed with the preoperative planning software to fashion a graft with the appropriate dimension and with the desired amount of lateralization. The bone graft is then compressed with the baseplate to the native glenoid and fixed with screws. Results: In select patients with careful preoperative planning, excellent outcomes can be achieved with careful gradual resumption of range of motion and strength with physical therapy. Sequential radiographic imaging is performed up to 6 months and beyond to confirm solid union of graft to native glenoid bone and incorporation into the baseplate. Discussion/Conclusion: Reverse total shoulder arthroplasty (rTSA) with humeral head autograft glenoid reconstruction is an excellent option to address severe glenoid bone loss and restore the native joint line for both primary osteoarthritis and rotator cuff arthropathy. Using 3D CT scans, 3D preoperative planning software and 3D printing of the glenoid can help achieve a good outcome. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Micro-column testing of the dynamic adsorption of Pb by Fe-Mg clay–quartz beds
Authors: Kypritidou Zacharenia , Gatou Maria-Anna , Argyraki Ariadne , Zotiadis Vasilios 
Published: January 2023

AbstractClays have been used widely as sorbents of potentially toxic elements, especially Pb. However, their adsorption efficiency has been studied mostly under static experimental conditions, which are labour-intensive. In this study, dynamic adsorption experiments were established using micro-columns to assess the adsorption behaviour of natural Fe-Mg-rich clays for Pb ions by varying the inlet solution pH, Pb concentration and flow rate. The clays, consisting of varying amounts of palygorskite and Fe-smectite, were diluted with quartz (Qz) sand to enhance their permeability. Greater adsorption capacity was observed for the mixed palygorskite/Fe-smectite-rich clay beds (45.2 ± 0.01 mg g–1) followed by the Fe-smectite-rich (35.7 ± 0.07 mg g–1) and palygorskite-rich (20.0 ± 0.03 mg g–1) clay beds. The results indicated that the greater adsorption efficiency of palygorskite/Fe-smectite-rich clays could be attributed to synergistic effects due to the coexistence of palygorskite and Fe-smectite clay phases, which have distinct physicochemical characteristics. Moreover, the results obtained showed good agreement with the static experiments, implying that the use of micro-columns could describe adsorption adequately over shorter experimental times.
Attitudes towards deprescribing and patient-related factors associated with willingness to stop medication among older patients with type 2 diabetes (T2D) in Indonesia: a cross-sectional survey study
Authors: Oktora Monika Pury , Yuniar Cindra Tri , Amalia Lia , Abdulah Rizky , Hak Eelko , Denig Petra 
Published: January 2023

Abstract
Background
Deprescribing of preventive medication is recommended in older patients with polypharmacy, including people with type 2 diabetes (T2D). It seems that many patients in low-middle-income countries are not willing to have their medicines deprescribed. This study aims to assess attitudes of Indonesian patients with T2D towards deprescribing in general and regarding specific cardiometabolic medicines, and factors influencing their willingness to stop medicines.

Methods
Primary care patients with T2D of ≥60 years in Indonesia completed the revised Patients’ Attitudes Towards Deprescribing (rPATD) questionnaire. Attitudes in general and for cardiometabolic medicines were reported descriptively. Proportions of patients willing to stop one or more medicines when recommended by different healthcare professionals were compared with Chi-square test. Multiple regression analysis was used to analyse the influence between patient-related factors and the willingness to stop medicines.

Results
The survey was completed by 196 participants (median age 69 years, 73% female). The percentages willing to stop medicines were 69, 67, and 41%, when the general practitioner (GP), the specialist, or the pharmacist initiates the process (p-value < 0.001). Higher perceived burden of medicines (p-value = 0.03) and less concerns about stopping (p-value < 0.001) were associated with a higher willingness to stop medicines if proposed by the GP. Patients using multiple glucose-regulating medicines were less willing to stop (p-value = 0.02). Using complementary or alternative medicines was not associated with the willingness to stop. If proposed by their pharmacist, patients without substantial education were more willing to stop than educated patients.

Conclusions
Only two-thirds of older people with T2D in Indonesia were willing to stop one or more of their medicines if the GP or specialist recommended this, and even less when the pharmacist proposed this. Attention should be given to concerns about stopping specific medicines, especially among patients using multiple glucose-lowering medicines, who may be more eligible but were less willing to accept deprescribing.
Exploring the association between lifetime traumatic experiences and positive psychotic symptoms in a group of long-stay patients with schizophrenia: the mediating effect of depression, anxiety, and distress
Authors: Rahme Clara , El Kadri Nisreen , Haddad Chadia , Fekih-Romdhane Feten , Obeid Sahar , Hallit Souheil 
Published: January 2023

Abstract
Background
Positive psychotic symptoms of schizophrenia are generally characterized by hallucinations and delusions. We propose to assess the relationship between total composite trauma and positive psychotic symptoms, along with the mediation effect of cognition, fear of COVID-19, insomnia, anxiety, distress, and depression of Lebanese patients with schizophrenia.

Methods
A cross-sectional study was carried out, between June and July 2021, by deriving data from 155 long-stay in-patients diagnosed with schizophrenia.

Results
Depression, anxiety, and distress but not cognitive impairment, insomnia, and fear of COVID-19) mediated the association between lifetime traumatic experiences and positive psychotic symptoms. Higher traumatic experiences were associated with greater depression, anxiety, and distress, indicating a significant positive total effect on positive psychotic scores. Moreover, higher depression, anxiety, and distress were significantly associated with higher positive psychotic symptoms.

Conclusion
Our results contribute to the existing knowledge by suggesting other possible intervention paths through mediating factors. Interventions that improve anxiety, depression, and distress severity may be effective in reducing positive psychotic symptoms among patients with schizophrenia having experienced lifetime trauma.
Women suffer but men die: survey data exploring whether this self-reported health paradox is real or an artefact of gender stereotypes
Authors: Phillips Susan P. , O’Connor Madlen , Vafaei Afshin 
Published: January 2023

Abstract
Background
Despite consistently reporting poorer health, women universally outlive men. We examine whether gender differences in lived circumstances considered, and meaning attributed to SRH by women and men might explain this paradox.

Methods
In an online survey 917 adults rated their health (SRH) and mental health (SRMH) and reflected upon what life experiences they considered in making their ratings. Descriptive findings were sex-disaggregated. The multiple experiences listed were then subject to factor analyses using principal components methods and orthogonal rotation.

Results
Women reported poorer SRH and SRMH. They considered a wider range of circumstances, weighing all but self-confidence and behaviors as more important to SRH than did men. Two underlying components, psychosocial context and clinical status were identified overall. Physical health and pain were more important elements of men’s clinical status and behaviors. Comparisons with others of the same age played a larger role in male psycho-social context. Two components also underpinned SRMH. These were clinical problems and psycho-social circumstances for which self-confidence was only important among men.

Conclusions
Women’s and men’s common interpretation of measures like SRH suggests that women’s health disadvantage is neither artefactual nor determined by gendered meanings of measures and does not explain the paradox. SRH and SRMH captured social circumstances for all. Convergence of characteristics women and men consider as central to health is evidence of the dynamism of gender with evolving social norms. The remaining divergence speaks to persisting traditional male stereotypes.
Clinical efficacy of transforaminal endoscopic discectomy in the treatment of recurrent lumbar disc herniation: a single-center retrospective analysis
Authors: Xu Gang , Zhang Xuexue , Zhu Mengye , Yan Yi , Zhang Yong , Zhang Jinjin , Li Fan , Xu Mu , Zhang Daying 
Published: January 2023

Abstract
Purpose
To investigate the clinical efficacy of transforaminal endoscopic discectomy (TED) in treating recurrent lumbar disc herniation.

Methods
Clinical datal of 31 patients who were hospitalized in the Department of Pain Management, First Affiliated Hospital of Nanchang University, between 2015 and 2018 due to recurrent lumbar disc herniation were collected and analyzed retrospectively. Visual analogue scale (VAS) scores and Japanese Orthopedic Association (JOA) scores were used to assess alterations of patients’ leg pain intensity and nerve function, respectively. The Modified MacNab criteria were used to evaluate patients’ excellent and good rates.

Results
Compared to clinical data before surgery, there was a significant reduction in VAS scores (P < 0.01) along with a significant improvement in JOA scores (P < 0.01) at 2 years after revision surgery. The patients’ excellent and good rates were 83.9% at the 2 years after surgery.

Conclusion
The TED is safe and effective in the long term and is applicable to the treatment of recurrent lumbar disc herniation.
Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer
Authors: Liu Zhe , Parveen Neha , Rehman Urushi , Aziz Aisha , Sheikh Afsana , Abourehab Mohammed A. S. , Guo Wei , Huang Junhao , Wang Zhenning , Kesharwani Prashant 
Published: January 2023

AbstractPancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor prognosis can be attributed to both troublesome detections at the initial stage, which makes the majority of the treatment options largely unsuccessful and leads to extensive metastasis, as well as to its distinct pathophysiological characteristics, such as rich desmoplastic tumours bounded by dysplastic and hypo perfused vessels restricting the mobility of therapeutic agents. Continued attempts have been made to utilise innovative measures for battling PC to increase the therapeutic effectiveness of therapies and overcome their cytotoxicity. Combined cancer targeting and gene silencing approach has shown improved outcomes in patients’ survival rates and quality of life, offering a potential solution to therapeutic complications. It particularly targets various barriers to alleviate delivery problems and diminish tumour recurrence and metastasis. While aptamers, a type of single-stranded nucleic acids with strong binding affinity and specificity to target molecules, have recently surfaced as a viable PC strategy, siRNA can interfere with the expression of certain genes. By concurrently suppressing genes and boosting targeted approach, the cocktail of siRNA/Aptamer and other therapeutic drugs can circumvent the multi-drug resistance phenomena. Additionally, combination therapy with additive or synergistic effects can considerably increase the therapeutic efficacy of anti-cancer medications. This study outlines the primary difficulties in treating PC, along with recent developments in siRNA/Aptamer mediated drug delivery to solve the major hiccup of oncology field.Graphical Abstract
Correlation analysis of differentially expressed long non-coding RNA HOTAIR with PTEN/PI3K/AKT pathway and inflammation in patients with osteoarthritis and the effect of baicalin intervention
Authors: Chen Xiaolu , Liu Jian , Sun Yanqiu , Wen Jianting , Zhou Qin , Ding Xiang , Zhang Xianheng 
Published: January 2023

Abstract
Objective
This study aims to investigate the correlation of long non-coding RNA HOX transcript antisense RNA (lncRNA HOTAIR) with the PTEN/PI3K/AKT pathway and clinical-related indicators in osteoarthritis (OA) and determine the effect of baicalin intervention.

Methods
The levels of clinical lipid metabolism indexes and immune-inflammatory indexes in OA patients and normal controls was detected. OA chondrocytes (OA-CHs) were induced with peripheral blood mononuclear cells (PBMCs), followed by baicalin treatment (50 ug/mL). RT-qPCR was performed to measure lncRNA HOTAIR expression. The levels of inflammatory cytokines and adiponectin were detected using ELISA kits. CCK-8 assay was used to assess the viability of CHs. The related protein expression was measured using Western blot analysis.

Results
LncRNA HOTAIR might act as a biomarker of OA in vivo. LncRNA HOTAIR was positively correlated with TC, hs-CRP, IgA, TNF-α, and VAS score. Overexpression of lncRNA HOTAIR in vitro inhibited cell proliferation, reduced IL-10 and PTEN expression, but augmented TNF-α, p-PI3K, and p-AKT proteins in OA-CHs stimulated by OA-PBMCs. The changes of above indexes were also observed in OA-CHs stimulated by OA-PBMCs treated with si-lncRNA HOTAIR or baicalin, implying the synergistic effects of baicalin and lncRNA HOTAIR silencing on OA.

Conclusions
Conclusively, lncRNA HOTAIR was highly expressed in OA-CHs, which facilitated OA inflammatory responses by orchestrating inflammatory cytokines and the PTEN/PI3K/AKT pathway. Baicalin exerted therapeutic effects by inhibiting the expression of lncRNA HOTAIR, decreasing the protein levels of p-PI3K and p-AKT, and increasing the protein levels of PTEN, APN, and ADIPOR1.
MTX-PEG-modified CG/DMMA polymeric micelles for targeted delivery of doxorubicin to induce synergistic autophagic death against triple-negative breast cancer
Authors: Cao Zhiwen , Liu Rui , Li Yang , Luo Xinyi , Hua Zhenglai , Wang Xiangpeng , Xue Zeyu , Zhang Zhengjia , Lu Cheng , Lu Aiping , Liu Yuanyan 
Published: January 2023

AbstractThe chemotherapy of triple-negative breast cancer based on doxorubicin (DOX) regimens suffers from great challenges on toxicity and autophagy raised off-target. In this study, a conjugate methotrexate-polyethylene glycol (shorten as MTX-PEG)-modified CG/DMMA polymeric micelles were prepared to endue DOX tumor selectivity and synergistic autophagic flux interference to reduce systematic toxicity and to improve anti-tumor capacity. The micelles could effectively promote the accumulation of autophagosomes in tumor cells and interfere with the degradation process of autophagic flux, collectively inducing autophagic death of tumor cells. In vivo and in vitro experiments showed that the micelles could exert improved anti-tumor effect and specificity, as well as reduced accumulation and damage of chemotherapeutic drugs in normal organs. The potential mechanism of synergistic autophagic death exerted by the synthesized micelles in MDA-MB-231 cells has been performed by autophagic flux-related pathway.
Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation
Authors: Ju Zhao , Pan Huiji , Qu Can , Xiao Liang , Zhou Meiling , Wang Yin , Luo Jinhua , Shen Liangfang , Zhou Pingkun , Huang Ruixue 
Published: January 2023

AbstractRadiation-induced pulmonary fibrosis (RIPF) is a major side effect experienced for patients with thoracic cancers after radiotherapy. RIPF is poor prognosis and limited therapeutic options available in clinic. Lactobacillus rhamnosus GG (LGG) is advantaged and widely used for health promotion. However. Whether LGG is applicable for prevention of RIPF and relative underlying mechanism is poorly understood. Here, we reported a unique comprehensive analysis of the impact of LGG and its’ derived lncRNA SNHG17 on radiation-induced epithelial–mesenchymal transition (EMT) in vitro and RIPF in vivo. As revealed by high-throughput sequencing, SNHG17 expression was decreased by LGG treatment in A549 cells post radiation and markedly attenuated the radiation-induced EMT progression (p < 0.01). SNHG17 overexpression correlated with poor overall survival in patients with lung cancer. Mechanistically, SNHG17 can stabilize PTBP1 expression through binding to its 3′UTR, whereas the activated PTBP1 can bind with the NICD part of Notch1 to upregulate Notch1 expression and aggravated EMT and lung fibrosis post radiation. However, SNHG17 knockdown inhibited PTBP1 and Notch1 expression and produced the opposite results. Notably, A549 cells treated with LGG also promoted cell apoptosis and increased cell G2/M arrest post radiation. Mice of RIPF treated with LGG decreased SNHG17 expression and attenuated lung fibrosis. Altogether, these data reveal that modulation of radiation-induced EMT and lung fibrosis by treatment with LGG associates with a decrease in SNHG17 expression and the inhibition of SNHG17/PTBP1/Nothch1 axis. Collectively, our results indicate that LGG exerts protective effects in RIPF and SNHG17 holds a potential marker of RIPF recovery in patients with thoracic cancers.
Pulmonary vein thrombosis associated with metastatic uterine leiomyosarcoma: a case report
Authors: Salimi Mehdi , Mohamadzadeh Dena , Bonyadi Mojdeh 
Published: January 2023

Abstract
Background
Pulmonary vein thrombosis (PVT) is rarely associated with malignancies. Leiomyosarcoma, a malignant tumor originating from smooth muscles, has never been reported as the etiology of PVT.

Case presentation
In this case report, we described a 43-year-old Kurdish woman with a known case of leiomyosarcoma who presented with hemoptysis, dyspnea, and pleuritic chest pain. Chest computed tomography (CT) angiography revealed a thrombus in the left infero-posterior pulmonary vein. She was successfully treated with unfractionated heparin administered intravenously followed by orally administered warfarin. At the end of the article, we describe and compare other reports of malignancy-related PVT.

Conclusions
While malignancies are not a common cause of PVT, both primary lung tumors and metastatic cancers could be associated with PVT. Delay in diagnosis may lead to serious complications and even death. Therefore, clinicians should be aware of the possibility of the development of PVT in different malignancies for appropriate diagnosis and treatment.