bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kepuasan Keuangan pada Generasi Sandwich dan Implikasinya terhadap Perilaku Mengelola Keuangan
Authors: Nurul Khasanah  , Umi Widyastuti  , Muhammad Fawaiq  
Published: June 2023

ABSTRACT
Financial satisfaction is determined by circumstances and understanding of personal financial needs. This research analysis is needed to investigate the determinants of financial satisfaction in the sandwich generation and their implications for financial management behavior. This research is quantitative and causal. Data collection was carried out through a research survey conducted in Greater Jakarta using an online questionnaire which was distributed via social media and involved one hundred and twenty five generations of sandwiches. The research findings show that financial literacy has a positive and significant effect on financial management behavior and financial satisfaction. The hypothesis is rejected where financial attitudes do not affect financial management behavior and financial satisfaction. Financial management behavior has a positive and significant effect on financial satisfaction in the sandwich generation.
Keyword: financial management behavior, financial satisfaction, sandwich generation

ABSTRAK
Kepuasan keuangan ditentukan oleh keadaan dan pemahaman akan kebutuhan finansial pribadinya. Maka, analisis penelitian ini diperlukan untuk menyelidiki faktor-faktor penentu kepuasan keuangan pada generasi sandwich dan implikasinya terhadap perilaku mengelola keuangan. Penelitian ini bersifat kuantitatif dan kausal. Pengumpulan data dilakukan melalui survei penelitian yang dilakukan di Jabodetabek dengan menggunakan kuesioner online yang disebarkan melalui media sosial dan melibatkan seratus dua puluh lima generasi sandwich. Temuan penelitian menunjukkan bahwa literasi keuangan berpengaruh positif dan signifikan terhadap perilaku pengelolaan keuangan dan kepuasan keuangan. Hipotesis ditolak dimana sikap keuangan tidak mempengaruhi perilaku mengelola keuangan dan kepuasan keuangan. Perilaku mengelola keuangan berpengaruh positif dan signifikan terhadap kepuasan keuangan pada generasi sandwich.
Kata kunci: perilaku mengelola keuangan, kepuasan keuangan, generasi sandwich
Integrated Framework for Constrained Optimization of Horizontal/Deviated Well Placement and Control for Geological CO2 Storage
Authors: Zou Amy , Durlofsky Louis J. 
Published: June 2023

Summary
A general framework for optimizing the locations and time-varying injection rates of a set of monobore wells for geological carbon storage is presented and applied. Two objective functions, minimization of mobile CO2 fraction at the end of the operation and maximization of storage efficiency, are considered separately in single-objective optimizations and in combination for biobjective optimization. Appropriate linear and nonlinear constraints, involving the geometry of the well configuration, injection rates, and injected mass (for pressure management), are specified. Two derivative-free algorithms, particle swarm optimization (PSO) and differential evolution (DE), are applied and assessed. The various constraints are treated using a preprocessing repair procedure, penalty functions, and a filter method. The framework uses multifidelity (MF) optimization, in which increasing levels of grid resolution are applied during the course of the optimization run. For single-objective optimizations, the MF approach is compared with high-resolution optimization. This treatment is shown to outperform high-resolution PSO and DE optimization in terms of both solution quality and computational requirements. The MF DE optimization case provides the best (feasible) solution, with a 0.090 mobile CO2 fraction at 200 years, which represents a 68% improvement over a heuristic base-case. For the second objective function, MF PSO provides a design that results in a storage efficiency of 0.074, which is about double the base-case value. The well configurations are much different for the two objective functions, with wells more closely spaced, resulting in a single merged plume, for the storage efficiency maximization case. For the mobile CO2 minimization case, by contrast, wells are separated and pulsed, which facilitates dissolution and residual trapping. Biobjective optimization is then performed, again using the MF approach, with a model based on an actual storage operation now under development. The resulting well configurations and CO2 plumes for selected Pareto-optimal solutions are presented.
Calcitriol Alleviates AKI Via Inhibiting Intestinal Inflammation and Restoring Intestinal Microbiota
Authors: Huo Aijing , FengmeiWang  
Published: June 2023

Abstract
Background：The intestinal microbiota affects the inflammatory status of the host and the prognosis of diseases. AKI can lead to microinflammation of intestinal tract and changes of intestinal flora. Calcitriol (Cal) has a protective effect on the intestine.
Methods and Results：In the AKI rat model, intestinal infiltration of inflammatory cells and the deterioration of renal function were significantly alleviated by Cal pretreatment. By increasing the levels of Zonula Occludens-1(ZO-1 and Occludin), Cal significantly prevented the destruction of the intestinal barrier in AKI. In AKI rats, Cal decreased the concentration of Proteobacteria and enhanced the linear discriminant (LDA) score of beneficial bacteria (such as Lactobacillus). Cal increased the expression of butyric acid among intestinal metabolites. Cal supplementation decreased serum LPS levels and downstream HMGB1-MYD88-NF-κB-p65 signaling.
Conclusions：High-dose Cal may play a protective role in AKI by regulating HMGB1-MYD88-NF-κB-p65 signaling pathways and the intestinal microbiota in rats. This study demonstrates the renal effects of Cal. The experiment revealed a close interaction between the kidney and the intestine. It provides new insights for the treatment of AKI.
Brain-derived neurotrophic factor serves as a tumor-trophic factor for lung cancer by controlling cell cycle
Authors: Sheng-Lan Wang , Xiu-Ying He , Li Chen , Yue-Xiang Zheng , Sheng-Lan Liu , Wang Ting-Hua , Yun-Hui Zhang 
Published: June 2023

Abstract
Background
The nervous system plays a key role in the lung development, and its dysfunction might be related to the occurrence of lung cancer. In fact, neurotrophic factors, especially brain-derived neurotrophic factor (BDNF), promote tumor malignancy, in which, however, the mechanism remains to be illustrated.
Methods
Lung cancer cell-A549 cell line was included in the study. HSV-BDNF-ORF/HSV-BDNF-shRNA vectors were prepared and transfected into A549 cells. The proliferation and migration were detected by xCELLigence Real-Time Cell Analyzer. Cell apoptosis was determined through Flow cytometry. The gene expression on transcriptome level was detected by gene microarray analysis. Bioinformatics analysis consisted of GO, KEGG and String analysis.
Results
Firstly, we found that the expression of BDNF in A549 cells was increased. Then we successfully constructed HSV-BDNF-ORF and HSV-BDNF-shRNA vectors, which could lead to the increase or decrease in BDNF expression after transfected into A549 cells, respectively. Moreover, BDNF served as “tumor-trophic factor” that promoted A549 cells proliferation and migration, while BDNF knockdown triggered the cell apoptosis of A549 cells. Mechanistically, BDNF-induced cell proliferation might be linked with the upregulation of cell cycle-related genes. The cell apoptosis triggered by BDNF knockdown should be attributing to the up-regulated apoptosis-associated genes.
Conclusion
BDNF served as a tumor-trophic factor mediating lung cancer cell proliferation and apoptosis by regulating the cell cycle-related and cell apoptosis associated-genes, indicating that BDNF might exert significant impact on treating lung cancer.
Synthesis of a New Biocomposite for Fertiliser Coating: Assessment of Biodegradabilityand Thermal Stability
Authors: Ketabchi Mohammed Reza , Soltani Salman Masoudi , Chan Andy 
Published: June 2023

Abstract
The bio- and thermal degradation as well as the water absorption properties of a novel biocomposite comprising cellulose nanoparticles, natural rubber and polylactic acid have been investigated. The biodegradation process was studied through an assembled condition based on the soil collected from the central Malaysian palm oil forests located in the University of Nottingham Malaysia. The effects of the presence of the cellulose nanoparticles and natural rubber on the biodegradation of polylactic acid were investigated. The biodegradation process was studied via thermal gravimetric analysis (TGA) and scanning electron microscopy (SEM). It was understood that the reinforcement of polylactic acid with cellulose nanoparticles and natural rubber increases the thermal stability by ~20 °C. Limited amorphous regions on the surface of the cellulose nanoparticles accelerated the biodegradation and water absorption processes. Based on the obtained results, it is predicted that complete biodegradation of the synthesised biocomposites can take place in 3062 h, highlighting promising agricultural applications for this biocomposite.
Study of road bitumens operational properties modified with phenol-cresol-formaldehyde resin
Authors: Pyshyev Serhiy , Demchuk Yuriy , Gunka Volodymyr , Donchenko Myroslava , Korchak Bohdan , Sidun Iurii , Poliuzhyn Ihor , Drapak Iryna 
Published: June 2023

Abstract

Phenol-cresol-formaldehyde resin (PhCR-F) was obtained using minor liquid products of coal coking by means of a relatively inexpensive method. It is shown that petroleum road bitumens, to which 1.0 wt % PhCR-F is added, in terms of basic physical and mechanical parameters comply the requirements of the regulatory document for bitumens modified with adhesive additives. Research of the operational properties of these modified bitumens as a binding material for asphalt concrete is described. It has been proven that modified bitumen can store stable properties during their application (counteraction to technological aging). The interaction of bitumens modified by PhCR-F with the surfaces of mineral materials, which occurs during the creation of asphalt concrete coatings, was studied. It was shown that the addition of 1.0 wt % PhCR-F to road bitumen significantly improves the adhesion of the binder to the mineral material and increases the hydrophobicity of such a coating.
Ultra-low power in-sensor neuronal computing with oscillatory retinal neurons for frequency-multiplexed, parallel machine vision
Authors: Ahsan Ragib , Chae Hyun Uk , Jalal Seyedeh Atiyeh Abbasi , Tao Jun , Das Subrata , Liu Hefei , Wu Jiang-Bin , Cronin Stephen , Wang Han , Sideris Constantine , Kapadia Rehan 
Published: June 2023

Abstract
In-sensor and near-sensor computing architectures enable multiply-accumulate operations to be carried out directly at the point of sensing. In-sensor architectures offer dramatic power and speed improvements over traditional von Neumann architectures by eliminating multiple analog-to-digital conversions, data storage, and data movement operations. Current in-sensor processing approaches rely on tunable sensors or additional weighting elements to perform linear functions such as multiply-accumulate operations as the sensor acquires data. We implement in-sensor computing with an oscillatory retinal neuron device that converts incident optical signals into voltage oscillations. We introduce a computing scheme based on the frequency shift of coupled oscillators that enables parallel, frequency multiplexed, non-linear operations on the inputs. Simulation elucidates how this computing occurs. We experimentally implement a 3×3 focal plane array of coupled neurons and show that functions approximating edge detection, thresholding, and segmentation occur in parallel. An example of inference on handwritten digits from the MNIST database is also experimentally demonstrated with a 3×3 array of coupled neurons feeding into a single hidden layer neural network, approximating a liquid state machine. This network demonstrated a 14.8% reduction in classification error from 2.16% to 1.84% compared to the same neural network with standard photodetector inputs. Finally, the equivalent energy consumption to carry out image processing operations, including peripherals such as the Fourier transform circuits, is projected to be ~24 aJ/OP.
Annexin A2 Promotes Epiretinal Membrane Formation and Subsequent Proliferative Vitreoretinopathy in Response to a Macrophage Inflammatory Signal in Mice
Authors: Luo Min , Almeida Dena , Dallacasagrande Valentina , Hedhli Nadia , Gupta Mrinali , D'Amico Donald , Kiss Szilard , Hajjar Katherine 
Published: June 2023

Abstract

Proliferative vitreoretinopathy (PVR) is a chronic, fibrosing, vision-threatening response to retinal injury that occurs in approximately half of individuals with penetrating ocular trauma, as well as in patients with rhegmatogenous retinal detachment or giant retinal tear. Current treatment for this common cause of post-traumatic blindness, remains unsatisfactory. Here, we show for the first time that the PVR reaction is profoundly blunted in a standard model system in annexin A2-deficient mice. We identify a new pathway whereby secretion of macrophage chemokines (macrophage inflammatory proteins, [MIP-1alpha and MIP-1beta]) signal the translocation of annexin A2 from the cytoplasm to the cell surface of retinal pigment epithelial cells (RPEs). Surface expression of A2 enables RPEs to activate surface proteases that allow them to delaminate, migrate to the vitreal surface of the retinal, and begin to secrete epiretinal membrane-forming proteins. RPE cell migration is markedly reduced in the injured retina in annexin A2-deficient mice, and antibody blockade of A2 appears to prevent PVR in wild type mice. We conclude that A2 may be a tractable, intraocular target for the prevention of PVR following eye injury.
Estimating Saturated Hydraulic Conductivity with an Automatic Infiltration Data Logger for BEST Algorithm
Authors: Baqerkhani Alireza , Abyaneh Hamid Zare , Bahmani Omid , Nozari Hamed 
Published: June 2023

Abstract
This article explains how a novel device called an automated infiltration data logger was designed, calibrated, and tested in the BEST algorithm. The purpose of this study is to compare data retrieval automatically and manually and its effect on the output results of BEST algorithms. This device is being used to monitor the cumulative infiltration curve into the soil from a ring with a constantpressure water head regulated by a capacitive level gauge, it stores all the information about the water infiltration curve vs. time. The significant advantage of the mentioned device is that it saves electronics. The trial test of the device was done at Shahid Chamran Research Farm in Kermanshah province, Iran. The saturated hydraulic conductivity was calculated using BEST methods and cumulative infiltration curves. A comparison was also performed between the manual technique and the automatic data logger infiltrometer method for extracting cumulative infiltration data. So that the average standard difference in BEST algorithms in the manual method is equal to 38.9 and in the automatic data collection method is equal to 6.1 percent. The automated data logger infiltrometer prevents soil surface disturbance and calculates positive hydraulic conductivity values by providing a constant water head on the soil surface. Other advantages of this device include improving measurement speed reducing the duration of water penetration in the soil into smaller intervals, enhancing data collecting accuracy, and not needing a professional operator.
Feasibility of an early progressive resistance exercise program for acute Achilles tendon rupture
Authors: Christensen Marianne , Silbernagel Karin Grävare , Zellers Jennifer A , Kjær Inge Lunding , Rathleff Michael Skovdal 
Published: June 2023

Abstract

Background
Long-term strength deficits are common after Achilles tendon ruptures. Early use of progressive resistance exercises may help reduce strength deficits, but the feasibility of this approach is unknown. The aim was to investigate the feasibility of early progressive resistance exercises regarding patient acceptability and compliance with the intervention.
Methods
We recruited patients with an acute Achilles tendon rupture treated non-surgically. During 9 weeks of immobilisation with a walking boot, participants attended weekly supervised physiotherapy sessions of progressive resistance exercises and performed home exercises, consisting of isometric ankle plantarflexion, seated heel-rise, and elastic band exercises. Acceptability was evaluated using a 7-point Likert scale (1=very unacceptable and 7=very acceptable) with feasibility threshold at 80% of the participants rating ≥4. Adherence to the exercises was defined as 80% of the participants performing at least 50% of the home exercises. During the intervention, tendon healing and adverse events were monitored.
Results
16 participants [mean age 46 (range 28-61), male/female = 13/3] completed the intervention. Pre-injury Achilles tendon total rupture score was 98 (SD 8). All participants rated the acceptability of the exercises ≥5 (moderate acceptable to very acceptable) at 9- and 13-weeks follow-up and 9/16 rated 7 points (very acceptable). Participants performed 74% (range 4-117) of the total home exercise sessions possible and 15/16 performed >50%. One participant was not compliant with the home exercises due to feeling uncomfortable performing these independently There were no re-ruptures, but one case of deep venous thrombosis.
Conclusions
The early progressive resistance exercise program for treatment of non-surgically treated Achilles tendon rupture was feasible. Future studies should investigate the efficacy of the progressive intervention.
Trial registration
The study was registered at Clinical Trials (NCT04121377) on the 29th of September 2019 ClinicalTrials:NCT04121377
Vehicle Steady Drifting Control with Safety Boundary Constraints
Authors: song zhanshuai , Hua Yuchen , Zhuang Ye , zhao Jiaqi , Wang Yuelian , Zhang Xiaochuan 
Published: June 2023

Abstract
The study on active safety motion control of automobiles is not only of great significance to the protection of people's lives and properties, but also of great significance to the development of unmanned driving technology under extreme conditions. Drifting maneuver suggests that the vehicle remains controllable when tires are at high slip conditions. Therefore, the research of drift control is helpful to achieve the active safety motion control of automobiles under extreme conditions. This paper focuses the steady drifting control with safety boundary constraints. The nonlinear 3-DOF vehicle model, the energy phase plane, the yaw acceleration isoclines, and sideslip rate isoclines are used to define the safety boundaries for steady drifting. ILQR algorithm are used for steady drifting control with safety boundary constraints. The simulation results suggests controller can better limit the yaw rate within the constraint boundary, compared with the controller without state boundary constraints.
Real-world experience with ponatinib therapy in chronic phase chronic myeloid leukemia: impact of depth of response on survival and prior exposure to nilotinib on arterial occlusive events
Authors: Al-Kali Aref , Litzow Mark , Begna Kebede , Hogan William , Patnaik Mrinal , Hashmi Shahrukh , Elliott Michelle , Alkhateeb Hassan , Gangat Naseema , Reichard Kaaren , VISWANATHA David , Badar Talha , KHARFAN-DABAJA Mohamed , Foran James , Murthy Hemant , Rivera candido , Abdelmagid Maymona , KARRAR OMER , Fleti Farah , Nayir Mohammed El , Tefferi Ayalew 
Published: June 2023

Abstract
We surveyed the performance of ponatinib, as salvage therapy, in a real-world setting of chronic phase chronic myeloid leukemia (CML-CP). Among 55 consecutive patients (median age 49 years) with relapsed/refractory CML-CP, 35 (64%) had failed ≥ 3 tyrosine kinase inhibitors (TKIs), 35 (64%) were pre-treated with nilotinib, and 14 (28%) harbored ABL1T315I. At start of ponatinib (median dose 30 mg/day), 40 patients were already in complete hematologic (CHR), 4 in complete cytogenetic (CCyR), 3 in major molecular (MMR) remission, while 8 had not achieved CHR (NR). Ponatinib improved the depth of response in 13 (33%), 3 (75%), 2 (66%), and 4 (50%) patients with CHR, CCyR, MMR, and NR, respectively (p = 0.02). At a median follow-up of 42 months, 13 (23%) deaths, 5 (9%) blast transformations, and 25 (45%) allogeneic transplants were recorded. Five/10-year post-ponatinib survival was 77%/58% with no significant difference when patients were stratified by allogeneic transplant (p = 0.94), ponatinib-induced deeper response (p = 0.28), or a post-ponatinib ≥ CCyR vs CHR remission state (p = 0.25). ABL1T315I was detrimental to survival (p = 0.04) but did not appear to affect response. Prior exposure to nilotinib was associated with higher risk of arterial occlusive events (AOEs; 11% vs 0%; age-adjusted p = 0.04). Ponatinib starting/maintenance dose (45 vs 15 mg/day) did not influence either treatment response or AOEs. Our observations support the use of a lower starting/maintenance dose for ponatinib in relapsed/refractory CML-CP but a survival advantage for deeper responses was not apparent and treatment might not overcome the detrimental impact of ABL1T315I on survival. The association between prior exposure to nilotinib and a higher risk of post-ponatinib AOEs requires further validation.
Recapitulation of single ventricle haemodynamics and associated interplay with breathing mechanics using clinically validated multimodal simulators
Authors: Horvath Markus , Story David van , Rosalia Luca , Starr Bryce , Jiang Mulan , Annese David , Piekarski Breanna , Ozturk Caglar , Agudelo Stephanie , Brassaw Kinsey , Valenza Maria , Herdes Emilia , Powell Andrew , Nido Pedro del , Roche Ellen 
Published: June 2023

Abstract

A range of congenital heart diseases result in a single functioning ventricle. This is palliatively treated by connecting the systemic and pulmonary vasculature in series, establishing what is known as the Fontan circulation. This physiology allows post-natal survival but causes aberrant haemodynamics that causes high morbidity and mortality. Due to limited clinical data, accurate modelling of single ventricle haemodynamics is critical for improving patient care. Although sophisticated haemodynamic models have been developed, their clinical relevance is hindered by their inability to mimic the biomechanical interactions of breathing pressures with vascular reservoirs as one interdependent unit which governs flow patterns and flow reversal in this physiology. Here, we report the development of a tuneable biomimetic single ventricle simulator platform that re-creates breathing mechanics and recapitulates Fontan venous flow patterns. Benchtop characterization, computational modelling, and MRI-based clinical validation demonstrate the ability of the platform to emulate the underlying mechanisms of the coupled breathing and flow mechanics that lead to venous flow reversal. We leverage this multimodal simulator platform to identify respiratory effort and rate as independent drivers for increased caval flow reversal in the Fontan physiology and measure haemodynamic parameters that cannot be obtained comprehensively in the clinic. Enabled by the modularity of this class of simulators, we evaluate the impact of gravity on the relationship between respiration and flow. Finally, we demonstrate the suitability of the clinically validated in vitro and in silico simulators as test platforms for Fontan support strategies which can help guide development of interventions to improve patient’s quality of life.